                         SEQUENCE LISTING

<110>  	Genizon BioSciences Inc.
	FRANKE, Andre
	SCHREIBER, Stephan
	REINHARD, Claudia
	KEITH, Tim
	LITTLE, Randall David
	NGUYEN-HUU, Quynh
	RAELSON, John Verner
	VAN EERDEWEGH, Paul


<120>  	GENEMAP OF THE HUMAN GENES ASSOCIATED WITH CROHN'S DISEASE

<130>  	15223001

<140>	Filed herewith
<141>	2008-09-18

<150>	60/973298
<151>	2007-09-18

<160>  7004

<170>  Genizon Biosciences InHouse Software

<210>  1
<211>  9646
<212>  DNA
<213>  Homo sapiens

<400>  1
tcgcccgccg cgcgcgccgg tccggcagcg cacgggttaa ggctggcacc gcgcccggcg     60

ggaggggggg cgcccacctc ccctcctccc cgcgccgggc atgcggggcc cagtgggcac    120

cgaggaggag ctgccgcggc tgttcgccga ggagatggag aatgaggacg agatgtcaga    180

agaagaagat ggtggtcttg aagccttcga tgactttttc cctgtggagc ccgtgagcct    240

tcctaagaag aagaaaccca agaagctcaa ggaaaacaag tgtaaaggga agcggaagaa    300

gaaagagggg agcaatgatg agctatcaga gaatgaagag gatctggaag agaagtcgga    360

gagtgaaggc agtgactact ccccgaataa aaagaagaag aagaaactca aggacaagaa    420

ggagaaaaaa gccaagcgaa aaaagaagga tgaggatgag gatgataatg atgatggatg    480

cttaaaggag cccaagtcct cggggcagct catggccgag tggggcctgg acgacgtgga    540

ctacctgttc tcggaggagg attaccacac gctgaccaac tacaaggcct tcagccagtt    600

cctcaggcca ctcattgcca agaagaaccc gaagatcccc atgtccaaaa tgatgaccgt    660

cctgggtgcc aagtggcggg agttcagcgc caacaacccc ttcaagggca gctccgcggc    720

agcagcggcg gcggcggtgg ctgcggctgt agagacggtc accatctccc ctccgctagc    780

cgtcagcccc ccgcaggtgc cccagcctgt gcctatccgc aaggccaaga ccaaggaggg    840

caaagggcct ggagtgagga agaagatcaa aggctccaaa gatgggaaga aaaagggcaa    900

agggaaaaag acggccgggc tcaagttccg cttcgggggg atcagcaaca agaggaagaa    960

aggctcctcg agtgaagaag atgagaggga ggagtcggac ttcgacagcg ccagcatcca   1020

cagtgcctcc gtgcgctccg aatgctctgc agccctgggc aagaagagca agaggaggcg   1080

caagaagaag aggattgatg atggtgacgg ctatgagaca gaccaccagg attactgtga   1140

ggtgtgccag cagggtgggg agatcatcct gtgcgacacc tgcccgaggg cctaccatct   1200

cgtatgcctg gacccagagc tggagaaggc tcccgagggc aagtggagct gcccccactg   1260

tgagaaggag gggatccagt gggagccgaa ggacgacgac gatgaagagg aggagggcgg   1320

ctgcgaggag gaggaggacg accacatgga gttctgccgc gtgtgcaagg acgggggcga   1380

gctgctctgc tgcgacgcct gcccctcctc ctaccacctg cattgcctca acccgccgct   1440

gcccgagatc ccaaacggtg aatggctctg cccgcgctgt acttgccccc cactgaaggg   1500

caaagtccag cggattctac actggaggtg gacggagccc cctgccccct tcatggtggg   1560

gctgccgggg cctgacgtgg agcccagcct ccctccacct aagcccctgg agggcatccc   1620

tgagagagag ttctttgtca agtgggcagg gctgtcctac tggcattgct cctgggtgaa   1680

ggagctacag ctggagctgt accacacggt gatgtatcgc aactaccaaa gaaagaacga   1740

catggatgag ccgcccccct ttgactacgg ctctggggat gaagacggca agagcgagaa   1800

gaggaagaac aaggaccccc tctatgccaa gatggaggag cgcttctacc gctatggcat   1860

caagccagag tggatgatga ttcaccgaat cctgaaccat agctttgaca agaaggggga   1920

tgtgcactac ctgatcaagt ggaaagacct gccctacgac cagtgcacct gggagatcga   1980

tgacatcgac atcccctact acgacaacct caagcaggcc tactggggcc acagggagct   2040

gatgctggga gaagacacca ggctgcccaa gaggctgctc aagaagggca agaagctgag   2100

ggacgacaag caggagaagc cgccggacac gcccattgtg gaccccacgg tcaagttcga   2160

caagcagcca tggtacatcg actccacagg cggcacactg cacccgtacc agctggaggg   2220

cctcaactgg ctgcgcttct cttgggccca gggcactgac accatcctgg ccgatgagat   2280

gggtctgggc aagacggtgc agaccatcgt gttcctttac tccctctaca aggagggcca   2340

ctccaaaggg ccctacctgg ttagcgcgcc cctctccacc atcatcaact gggaacgcga   2400

gtttgagatg tgggcgcccg acttctacgt ggtcacctac acgggggaca aggagagccg   2460

ctcggtgatt cgggagaacg agttttcctt tgaggacaac gccattcgga gtgggaagaa   2520

ggtattccgt atgaagaaag aagtgcagat caaattccac gtgctgctca cctcctatga   2580

gctcatcacc attgaccagg ccatcctggg ctccatcgag tgggcctgcc tggtggtaga   2640

tgaggcccac cgcctcaaga acaaccagtc caagtttttt agggtcttaa acagctacaa   2700

gattgattac aagctgctgc tgacagggac cccccttcag aacaacctgg aggagctgtt   2760

ccatctcctc aacttcctga ctccagagag gttcaacaac ctggagggct tcctggagga   2820

gtttgctgac atctccaagg aagaccagat caagaagctg catgacctgc tggggccgca   2880

catgctcagg cggctcaagg ctgacgtgtt caagaacatg ccggccaaga ccgagctcat   2940

tgtccgggtg gagctgagcc agatgcagaa gaagtactac aagttcatcc tcacacggaa   3000

ctttgaggca ctgaactcca aggggggcgg gaaccaagta tcgctgctca acatcatgat   3060

ggacctgaaa aagtgctgca accaccccta cctcttccct gtggctgccg tggaggcccc   3120

tgtcttgccc aatggctcct acgatggaag ctccctggtc aagtcttcag ggaagctcat   3180

gctgctacag aagatgctga agaaactgcg ggatgagggg caccgtgtgc tcatcttctc   3240

ccagatgacc aagatgctgg acctcctgga ggacttcctg gagtacgaag gctacaagta   3300

tgagcggatt gatggtggca tcaccggggg cctccggcag gaggcaatcg acagattcaa   3360

tgcccccggg gcccagcagt tctgcttcct cctctcaacc cgggcaggtg gtctgggcat   3420

caacctggcc acggcggaca ctgtcatcat ctacgactcg gactggaacc cgcacaatga   3480

catccaggcc ttcagccgcg cccaccgcat cggccagaac aagaaggtga tgatctaccg   3540

cttcgtgact cgggcctcgg tggaggagcg catcacgcag gtggccaagc gcaagatgat   3600

gctcacccac ctggtggtgc ggcccggcct cggctccaag tcggggtcca tgaccaagca   3660

ggagctggac gacatcctca agttcggcac ggaggaactc ttcaaggacg acgtggaggg   3720

catgatgtct cagggccaga ggccggtcac acccatccct gatgtccagt cctccaaagg   3780

ggggaacttg gccgccagtg caaagaagaa gcacggtagc accccgccag gtgacaacaa   3840

ggacgtggag gacagcagtg tgatccacta tgacgatgcg gccatctcca agctgctgga   3900

ccggaaccag gacgctacag atgacacgga gctacagaac atgaacgagt acctgagctc   3960

cttcaaggtg gcgcagtacg tggtgcgcga ggaggacggc gtggaggagg tggagcggga   4020

aatcatcaag caggaggaga acgtggaccc cgactactgg gagaagctgc tgcggcacca   4080

ctatgagcag cagcaggagg acctggcccg caacctgggc aagggcaagc gcatccgcaa   4140

gcaggtcaac tacaacgatg cctcccagga ggaccaggag tggcaggatg agctctctga   4200

taaccagtca gaatattcca ttggctctga ggatgaggat gaggactttg aagagaggcc   4260

ggaagggcag agtggacgac gacaatcccg gaggcagctg aagagtgaca gggacaagcc   4320

cctgcccccg cttctcgccc gagttggtgg caacatcgag gtgctgggct tcaatgcccg   4380

acagcggaag gcctttctga acgccatcat gcgctggggc atgcccccgc aggacgcctt   4440

caactcccac tggctggtgc gggaccttcg agggaagagc gagaaggagt ttagagccta   4500

tgtgtccctc ttcatgcggc acctgtgtga gccgggggcg gatggtgcag agaccttcgc   4560

agacggcgtg ccccgggagg gcctctccag gcagcacgtg ctgacccgca tcggggtcat   4620

gtcactagtt aggaagaagg ttcaggagtt tgagcatgtc aacgggaagt acagcacccc   4680

agacttgatc cctgaggggc ccgaggggaa gaagtcgggc gaggtgatct cctcggaccc   4740

caacacacca gtgcccgcca gccctgccca cctcctgcca gccccgctgg gcctgccaga   4800

caaaatggaa gcccagctgg gctacatgga tgagaaagac cccggggcac agaagccaag   4860

gcagcccctg gaagtccagg cccttccagc cgccttggat agagtggaga gtgaggacaa   4920

gcacgagagc ccagccagca aggagagagc ccgagaggag cggccagagg agacggagaa   4980

ggccccgccc tccccggagc agctgccgag agaggaggtg cttcctgaga aggagaagat   5040

cctggacaag ctggagctga gcttgatcca cagcagaggg gacagttccg aactcaggcc   5100

agatgacacc aaggctgagg agaaggagcc cattgaaaca cagcaaaatg gtgacaaaga   5160

ggaagatgac gaggggaaga aggaggacaa gaaggggaaa ttcaagttca tgttcaacat   5220

cgcggacggg ggcttcacgg agttgcacac gctgtggcag aacgaggagc gggctgctgt   5280

atcctctggg aaaatctacg acatctggca ccggcgccat gactactggc tgctggcggg   5340

catcgtgacg cacggctacg cccgctggca ggacatccag aatgacccac ggtacatgat   5400

cctcaacgag cccttcaagt ctgaggtcca caagggcaac tacctggaga tgaagaacaa   5460

gttcctggcc cgcaggttta agctgctgga gcaggcgttg gtcattgagg agcagctccg   5520

gagggccgcg tacctgaaca tgacgcagga ccccaaccac cccgccatgg ccctcaacgc   5580

ccgcctggct gaagtggagt gcctcgccga gagccaccag cacctgtcca aggagtccct   5640

tgctgggaac aagcctgcca atgccgtcct gcacaaggtc ctgaaccagc tggaggagct   5700

gctgagcgac atgaaggccg acgtgacccg gctgccatcc atgctgtccc gcatcccccc   5760

ggtggccgcc cggctgcaga tgtcggagcg cagcatcctg agccgcctga ccaaccgcgc   5820

cggggacccc accatccagc agggcgcttt cggctcctcc cagatgtaca gcaacaactt   5880

tgggcccaac ttccggggcc ctggaccggg agggattgtc aactacaacc agatgcccct   5940

ggggccctat gtgaccgata tctagccgtc ctcgagactt ccctgtgttg cagcgctcat   6000

ttccagctga gccacgcctg ccgggccacc tgcccgaccc acatgggaga gaaaagctgc   6060

caccttttta ggagccagcg ccaccttggg acaaaaaggg aaacctagta atgccatcac   6120

atggaggacg aggcccagct cagctgggcc agagcccaga agtgccacct catcataatt   6180

caagtgttct tccacacagc gttgccccca caaccacgcc ggacgtgccc cctcgccacc   6240

ttttccagac gacttcttag aagagatttc atttatttgt acatcttttg cactttccta   6300

ttgaagactt gaacacgttt gtcttgataa aagttggatg acgtatggaa gattcgaacc   6360

tgcagcactg atgtctcttt accgatgggt tccagaccca aggtagtcct ggcactgccc   6420

tgtggactca gcccagctgg ggaggacatg gcgcccggtg ccctaggagc cctcagtgtc   6480

ccctacctga cctgtctgca cctgtgtgac agccccttct gatttggccc cctgcccgct   6540

tggagcctcc cagcaccaga cagggcaggt ttggggagcc gctgtcgagc cctatggtga   6600

gaccctggct gacatttccc ctccttcctg ccaaggctgg aggccgccag gtgtttgctc   6660

tctccttgtg gggaggtgga tcctctgcca gcaggtgtct gtccccggcc cagcgcatct   6720

tgaaggccct ggactctgtt accagtgggg ggcctgtggc cccggctctt cacagcaggc   6780

agaagcgtat gatcccaggg agggtgggct gggggggggc cagcacttgc ctcggagcca   6840

ctgctgcgtt gggtttgcct tctgccagag gtgtggttaa gggcagtgat agctgcgccc   6900

cagcaaggag ggtcatgggc cctgagctgg cccaggagac cctggccctg ccctgtgccc   6960

tgggatgcct accctgccca cctccggagg tggaaccggg ctgcccctgg gggcctggac   7020

ttgtcccatt cccctgtccc tggaaaggcc ttcccggggg ctttttgcct gaggctgcac   7080

tcttggaagg tgtggggaga gttctgcctg gagggggact ggacccagtg ccctctgcag   7140

acccctccca gccgcagcac caagggcttg ctgccttgtt tcctgccagg agcgccctga   7200

catcccaaaa ccatcttccc acatgtgggt tgttggaatc ccacccactc ccccggaccc   7260

tgcccctcca agttggggac ggagatgggg agcaggtcag gccctcccta ggcctgtttg   7320

tgtgtgatcc ttctcctggc cccaggtcga cctggaaggc gtttctgagt cttgtactgg   7380

gaccttccca gggaaggtgc cttggggtgc agaatcctgg gaatgttagg aaagggctgc   7440

gtgaaaaacc cagctgggcc tggggtggag gtgcacacgg gctggggctc agctccttgg   7500

agagggcctg cctgggactg agggggccag ggctgggtca ggattcacca gcttgtgttg   7560

cagacactgg agcaattgcc tggccctccc taagccctat atgcctcact cataatgagg   7620

ctgtctctga accccggagg gcgggaccta caagtccttc ctcttggcgc attcccacac   7680

tccagtctgg atccaggtct gcaaggccag cccgaccctg acactgcacg tgggcgtagt   7740

ggggagcacc ctggagtgga gatgattgtc agcgggctca catgttatgg ttcatccaca   7800

tgcgtgttgt gtgctctgcg gtgcctcctg gcaaagggtc ctggctcggg tcagaagctc   7860

actcccgtgc cctcgtcccc aaacaagcag tggcaagcac tggggttggc cctcgttggg   7920

agcagtgccc accttccttg gcccacagca gataggtccc gagcagcagg actggaggcc   7980

tgtggcggtc agggcagggg tctgtgtctc caccccaagg gctgatggtc cctcccctgt   8040

gcgccttcct ctcaggcagg cttgctctgt cccttcctct ctgcttccct cccaggcctc   8100

gccagggctc ccttctcctc tgcctggtta gactcgggca cccaggaaag cctggccagg   8160

gctcctttgg gcctgggccc cctgcactgc ctggtccaga aggggtggtg ctgtccgtgg   8220

ccagcacccc ggggcccggg aggggtgggc tactagagtc agagcgggtt tggggctgac   8280

cagtttggga gaggagaaaa gatctgagaa tgtccttctt ggtttgtcag tcatctctgc   8340

caaaagtggt gatggtggtg tccgtatgtt tggcgtcttt gggctgggtt tggtttttgc   8400

tgctggtaga atcagggtcc tcgggcatga acgcgagccc aaagtgccag tctgcgattg   8460

gaaatttcca gccactttaa gccagtgctg agtagggctt ctgcagagcc atgtttgagc   8520

caaggtcttg gaaggcattg ccccatgggc tcaggtgact cggggtggag tgagcacgtc   8580

tgcagggccc tctcatacac gcctgaggca gaagcagcgt cccccgtgaa agccaccttc   8640

cgaagctcct gcgttttttg caaacttggc ttcccccagg ggcaggctgg actttccctg   8700

ccccctatga ttgaagtcct cctgcttttg ggggctgcct tcccagagtc ccccgggtgc   8760

tcccctgccg aggtcaggag ctgaccaagc cttggcccgg tgacacctgc agccctcact   8820

cctgtcatcc caggacactt gaggcccaag gaggtggagt ggagagtggg ctcgggtaca   8880

tgggagccag aagccagatg gacttggtca agtgttggtc acttggagcc tccagtgtgc   8940

gtcagggtct gtgggcaggg gacagggcgt gggtgggggc cgaggctggc acgcccctct   9000

gccctcaccg tcttggtgac ctggcctcgg cccctccccc aagtctcttc tgtgcaaggc   9060

ccgcctcggc ctcggcagct ggttcctgtc ccgttttctg tgtctgaaag tttacaggtt   9120

gtggtgcatc agcccaaact cactggcgtt gtgttttttt tttctttaat tttcagattt   9180

tttttttaaa caaagtattt ttttaggtgc gataacccag aaagggcccg ttgggtgtgt   9240

gtgtgtgtcc tgaactcctc aagcagcgat tggagcccaa gcacccctgg agaggaaggg   9300

agggtcccca ctggcccgtg gggtctgagt tcaggggtgt ggagggagca gactccaccg   9360

gcccaggccc agctaagagg gggccgaccc ctttccccag gcacagcccc aggctggcaa   9420

agggagggcc ctgggctggg tgcagggcgc gccaggagtc ccagccaggg tggccccggc   9480

gggggcgggt ccagctttgg aagccaggct cccctgtgag ccgtggcttg tctggtcttc   9540

gcccacggga ggctggacag aggctgtagc caacacaatc acctttactt tgtactctgt   9600

gtgtatgttt tggttttctg tgttttaata aatcctttgg gaaagg                  9646


<210>  2
<211>  1954
<212>  PRT
<213>  Homo sapiens

<400>  2


Met Arg Gly Pro Val Gly Thr Glu Glu Glu Leu Pro Arg Leu Phe Ala 
1               5                   10                  15      


Glu Glu Met Glu Asn Glu Asp Glu Met Ser Glu Glu Glu Asp Gly Gly 
            20                  25                  30          


Leu Glu Ala Phe Asp Asp Phe Phe Pro Val Glu Pro Val Ser Leu Pro 
        35                  40                  45              


Lys Lys Lys Lys Pro Lys Lys Leu Lys Glu Asn Lys Cys Lys Gly Lys 
    50                  55                  60                  


Arg Lys Lys Lys Glu Gly Ser Asn Asp Glu Leu Ser Glu Asn Glu Glu 
65                  70                  75                  80  


Asp Leu Glu Glu Lys Ser Glu Ser Glu Gly Ser Asp Tyr Ser Pro Asn 
                85                  90                  95      


Lys Lys Lys Lys Lys Lys Leu Lys Asp Lys Lys Glu Lys Lys Ala Lys 
            100                 105                 110         


Arg Lys Lys Lys Asp Glu Asp Glu Asp Asp Asn Asp Asp Gly Cys Leu 
        115                 120                 125             


Lys Glu Pro Lys Ser Ser Gly Gln Leu Met Ala Glu Trp Gly Leu Asp 
    130                 135                 140                 


Asp Val Asp Tyr Leu Phe Ser Glu Glu Asp Tyr His Thr Leu Thr Asn 
145                 150                 155                 160 


Tyr Lys Ala Phe Ser Gln Phe Leu Arg Pro Leu Ile Ala Lys Lys Asn 
                165                 170                 175     


Pro Lys Ile Pro Met Ser Lys Met Met Thr Val Leu Gly Ala Lys Trp 
            180                 185                 190         


Arg Glu Phe Ser Ala Asn Asn Pro Phe Lys Gly Ser Ser Ala Ala Ala 
        195                 200                 205             


Ala Ala Ala Ala Val Ala Ala Ala Val Glu Thr Val Thr Ile Ser Pro 
    210                 215                 220                 


Pro Leu Ala Val Ser Pro Pro Gln Val Pro Gln Pro Val Pro Ile Arg 
225                 230                 235                 240 


Lys Ala Lys Thr Lys Glu Gly Lys Gly Pro Gly Val Arg Lys Lys Ile 
                245                 250                 255     


Lys Gly Ser Lys Asp Gly Lys Lys Lys Gly Lys Gly Lys Lys Thr Ala 
            260                 265                 270         


Gly Leu Lys Phe Arg Phe Gly Gly Ile Ser Asn Lys Arg Lys Lys Gly 
        275                 280                 285             


Ser Ser Ser Glu Glu Asp Glu Arg Glu Glu Ser Asp Phe Asp Ser Ala 
    290                 295                 300                 


Ser Ile His Ser Ala Ser Val Arg Ser Glu Cys Ser Ala Ala Leu Gly 
305                 310                 315                 320 


Lys Lys Ser Lys Arg Arg Arg Lys Lys Lys Arg Ile Asp Asp Gly Asp 
                325                 330                 335     


Gly Tyr Glu Thr Asp His Gln Asp Tyr Cys Glu Val Cys Gln Gln Gly 
            340                 345                 350         


Gly Glu Ile Ile Leu Cys Asp Thr Cys Pro Arg Ala Tyr His Leu Val 
        355                 360                 365             


Cys Leu Asp Pro Glu Leu Glu Lys Ala Pro Glu Gly Lys Trp Ser Cys 
    370                 375                 380                 


Pro His Cys Glu Lys Glu Gly Ile Gln Trp Glu Pro Lys Asp Asp Asp 
385                 390                 395                 400 


Asp Glu Glu Glu Glu Gly Gly Cys Glu Glu Glu Glu Asp Asp His Met 
                405                 410                 415     


Glu Phe Cys Arg Val Cys Lys Asp Gly Gly Glu Leu Leu Cys Cys Asp 
            420                 425                 430         


Ala Cys Pro Ser Ser Tyr His Leu His Cys Leu Asn Pro Pro Leu Pro 
        435                 440                 445             


Glu Ile Pro Asn Gly Glu Trp Leu Cys Pro Arg Cys Thr Cys Pro Pro 
    450                 455                 460                 


Leu Lys Gly Lys Val Gln Arg Ile Leu His Trp Arg Trp Thr Glu Pro 
465                 470                 475                 480 


Pro Ala Pro Phe Met Val Gly Leu Pro Gly Pro Asp Val Glu Pro Ser 
                485                 490                 495     


Leu Pro Pro Pro Lys Pro Leu Glu Gly Ile Pro Glu Arg Glu Phe Phe 
            500                 505                 510         


Val Lys Trp Ala Gly Leu Ser Tyr Trp His Cys Ser Trp Val Lys Glu 
        515                 520                 525             


Leu Gln Leu Glu Leu Tyr His Thr Val Met Tyr Arg Asn Tyr Gln Arg 
    530                 535                 540                 


Lys Asn Asp Met Asp Glu Pro Pro Pro Phe Asp Tyr Gly Ser Gly Asp 
545                 550                 555                 560 


Glu Asp Gly Lys Ser Glu Lys Arg Lys Asn Lys Asp Pro Leu Tyr Ala 
                565                 570                 575     


Lys Met Glu Glu Arg Phe Tyr Arg Tyr Gly Ile Lys Pro Glu Trp Met 
            580                 585                 590         


Met Ile His Arg Ile Leu Asn His Ser Phe Asp Lys Lys Gly Asp Val 
        595                 600                 605             


His Tyr Leu Ile Lys Trp Lys Asp Leu Pro Tyr Asp Gln Cys Thr Trp 
    610                 615                 620                 


Glu Ile Asp Asp Ile Asp Ile Pro Tyr Tyr Asp Asn Leu Lys Gln Ala 
625                 630                 635                 640 


Tyr Trp Gly His Arg Glu Leu Met Leu Gly Glu Asp Thr Arg Leu Pro 
                645                 650                 655     


Lys Arg Leu Leu Lys Lys Gly Lys Lys Leu Arg Asp Asp Lys Gln Glu 
            660                 665                 670         


Lys Pro Pro Asp Thr Pro Ile Val Asp Pro Thr Val Lys Phe Asp Lys 
        675                 680                 685             


Gln Pro Trp Tyr Ile Asp Ser Thr Gly Gly Thr Leu His Pro Tyr Gln 
    690                 695                 700                 


Leu Glu Gly Leu Asn Trp Leu Arg Phe Ser Trp Ala Gln Gly Thr Asp 
705                 710                 715                 720 


Thr Ile Leu Ala Asp Glu Met Gly Leu Gly Lys Thr Val Gln Thr Ile 
                725                 730                 735     


Val Phe Leu Tyr Ser Leu Tyr Lys Glu Gly His Ser Lys Gly Pro Tyr 
            740                 745                 750         


Leu Val Ser Ala Pro Leu Ser Thr Ile Ile Asn Trp Glu Arg Glu Phe 
        755                 760                 765             


Glu Met Trp Ala Pro Asp Phe Tyr Val Val Thr Tyr Thr Gly Asp Lys 
    770                 775                 780                 


Glu Ser Arg Ser Val Ile Arg Glu Asn Glu Phe Ser Phe Glu Asp Asn 
785                 790                 795                 800 


Ala Ile Arg Ser Gly Lys Lys Val Phe Arg Met Lys Lys Glu Val Gln 
                805                 810                 815     


Ile Lys Phe His Val Leu Leu Thr Ser Tyr Glu Leu Ile Thr Ile Asp 
            820                 825                 830         


Gln Ala Ile Leu Gly Ser Ile Glu Trp Ala Cys Leu Val Val Asp Glu 
        835                 840                 845             


Ala His Arg Leu Lys Asn Asn Gln Ser Lys Phe Phe Arg Val Leu Asn 
    850                 855                 860                 


Ser Tyr Lys Ile Asp Tyr Lys Leu Leu Leu Thr Gly Thr Pro Leu Gln 
865                 870                 875                 880 


Asn Asn Leu Glu Glu Leu Phe His Leu Leu Asn Phe Leu Thr Pro Glu 
                885                 890                 895     


Arg Phe Asn Asn Leu Glu Gly Phe Leu Glu Glu Phe Ala Asp Ile Ser 
            900                 905                 910         


Lys Glu Asp Gln Ile Lys Lys Leu His Asp Leu Leu Gly Pro His Met 
        915                 920                 925             


Leu Arg Arg Leu Lys Ala Asp Val Phe Lys Asn Met Pro Ala Lys Thr 
    930                 935                 940                 


Glu Leu Ile Val Arg Val Glu Leu Ser Gln Met Gln Lys Lys Tyr Tyr 
945                 950                 955                 960 


Lys Phe Ile Leu Thr Arg Asn Phe Glu Ala Leu Asn Ser Lys Gly Gly 
                965                 970                 975     


Gly Asn Gln Val Ser Leu Leu Asn Ile Met Met Asp Leu Lys Lys Cys 
            980                 985                 990         


Cys Asn His Pro Tyr Leu Phe Pro  Val Ala Ala Val Glu  Ala Pro Val 
        995                 1000                 1005             


Leu Pro  Asn Gly Ser Tyr Asp  Gly Ser Ser Leu Val  Lys Ser Ser 
    1010                 1015                 1020             


Gly Lys  Leu Met Leu Leu Gln  Lys Met Leu Lys Lys  Leu Arg Asp 
    1025                 1030                 1035             


Glu Gly  His Arg Val Leu Ile  Phe Ser Gln Met Thr  Lys Met Leu 
    1040                 1045                 1050             


Asp Leu  Leu Glu Asp Phe Leu  Glu Tyr Glu Gly Tyr  Lys Tyr Glu 
    1055                 1060                 1065             


Arg Ile  Asp Gly Gly Ile Thr  Gly Gly Leu Arg Gln  Glu Ala Ile 
    1070                 1075                 1080             


Asp Arg  Phe Asn Ala Pro Gly  Ala Gln Gln Phe Cys  Phe Leu Leu 
    1085                 1090                 1095             


Ser Thr  Arg Ala Gly Gly Leu  Gly Ile Asn Leu Ala  Thr Ala Asp 
    1100                 1105                 1110             


Thr Val  Ile Ile Tyr Asp Ser  Asp Trp Asn Pro His  Asn Asp Ile 
    1115                 1120                 1125             


Gln Ala  Phe Ser Arg Ala His  Arg Ile Gly Gln Asn  Lys Lys Val 
    1130                 1135                 1140             


Met Ile  Tyr Arg Phe Val Thr  Arg Ala Ser Val Glu  Glu Arg Ile 
    1145                 1150                 1155             


Thr Gln  Val Ala Lys Arg Lys  Met Met Leu Thr His  Leu Val Val 
    1160                 1165                 1170             


Arg Pro  Gly Leu Gly Ser Lys  Ser Gly Ser Met Thr  Lys Gln Glu 
    1175                 1180                 1185             


Leu Asp  Asp Ile Leu Lys Phe  Gly Thr Glu Glu Leu  Phe Lys Asp 
    1190                 1195                 1200             


Asp Val  Glu Gly Met Met Ser  Gln Gly Gln Arg Pro  Val Thr Pro 
    1205                 1210                 1215             


Ile Pro  Asp Val Gln Ser Ser  Lys Gly Gly Asn Leu  Ala Ala Ser 
    1220                 1225                 1230             


Ala Lys  Lys Lys His Gly Ser  Thr Pro Pro Gly Asp  Asn Lys Asp 
    1235                 1240                 1245             


Val Glu  Asp Ser Ser Val Ile  His Tyr Asp Asp Ala  Ala Ile Ser 
    1250                 1255                 1260             


Lys Leu  Leu Asp Arg Asn Gln  Asp Ala Thr Asp Asp  Thr Glu Leu 
    1265                 1270                 1275             


Gln Asn  Met Asn Glu Tyr Leu  Ser Ser Phe Lys Val  Ala Gln Tyr 
    1280                 1285                 1290             


Val Val  Arg Glu Glu Asp Gly  Val Glu Glu Val Glu  Arg Glu Ile 
    1295                 1300                 1305             


Ile Lys  Gln Glu Glu Asn Val  Asp Pro Asp Tyr Trp  Glu Lys Leu 
    1310                 1315                 1320             


Leu Arg  His His Tyr Glu Gln  Gln Gln Glu Asp Leu  Ala Arg Asn 
    1325                 1330                 1335             


Leu Gly  Lys Gly Lys Arg Ile  Arg Lys Gln Val Asn  Tyr Asn Asp 
    1340                 1345                 1350             


Ala Ser  Gln Glu Asp Gln Glu  Trp Gln Asp Glu Leu  Ser Asp Asn 
    1355                 1360                 1365             


Gln Ser  Glu Tyr Ser Ile Gly  Ser Glu Asp Glu Asp  Glu Asp Phe 
    1370                 1375                 1380             


Glu Glu  Arg Pro Glu Gly Gln  Ser Gly Arg Arg Gln  Ser Arg Arg 
    1385                 1390                 1395             


Gln Leu  Lys Ser Asp Arg Asp  Lys Pro Leu Pro Pro  Leu Leu Ala 
    1400                 1405                 1410             


Arg Val  Gly Gly Asn Ile Glu  Val Leu Gly Phe Asn  Ala Arg Gln 
    1415                 1420                 1425             


Arg Lys  Ala Phe Leu Asn Ala  Ile Met Arg Trp Gly  Met Pro Pro 
    1430                 1435                 1440             


Gln Asp  Ala Phe Asn Ser His  Trp Leu Val Arg Asp  Leu Arg Gly 
    1445                 1450                 1455             


Lys Ser  Glu Lys Glu Phe Arg  Ala Tyr Val Ser Leu  Phe Met Arg 
    1460                 1465                 1470             


His Leu  Cys Glu Pro Gly Ala  Asp Gly Ala Glu Thr  Phe Ala Asp 
    1475                 1480                 1485             


Gly Val  Pro Arg Glu Gly Leu  Ser Arg Gln His Val  Leu Thr Arg 
    1490                 1495                 1500             


Ile Gly  Val Met Ser Leu Val  Arg Lys Lys Val Gln  Glu Phe Glu 
    1505                 1510                 1515             


His Val  Asn Gly Lys Tyr Ser  Thr Pro Asp Leu Ile  Pro Glu Gly 
    1520                 1525                 1530             


Pro Glu  Gly Lys Lys Ser Gly  Glu Val Ile Ser Ser  Asp Pro Asn 
    1535                 1540                 1545             


Thr Pro  Val Pro Ala Ser Pro  Ala His Leu Leu Pro  Ala Pro Leu 
    1550                 1555                 1560             


Gly Leu  Pro Asp Lys Met Glu  Ala Gln Leu Gly Tyr  Met Asp Glu 
    1565                 1570                 1575             


Lys Asp  Pro Gly Ala Gln Lys  Pro Arg Gln Pro Leu  Glu Val Gln 
    1580                 1585                 1590             


Ala Leu  Pro Ala Ala Leu Asp  Arg Val Glu Ser Glu  Asp Lys His 
    1595                 1600                 1605             


Glu Ser  Pro Ala Ser Lys Glu  Arg Ala Arg Glu Glu  Arg Pro Glu 
    1610                 1615                 1620             


Glu Thr  Glu Lys Ala Pro Pro  Ser Pro Glu Gln Leu  Pro Arg Glu 
    1625                 1630                 1635             


Glu Val  Leu Pro Glu Lys Glu  Lys Ile Leu Asp Lys  Leu Glu Leu 
    1640                 1645                 1650             


Ser Leu  Ile His Ser Arg Gly  Asp Ser Ser Glu Leu  Arg Pro Asp 
    1655                 1660                 1665             


Asp Thr  Lys Ala Glu Glu Lys  Glu Pro Ile Glu Thr  Gln Gln Asn 
    1670                 1675                 1680             


Gly Asp  Lys Glu Glu Asp Asp  Glu Gly Lys Lys Glu  Asp Lys Lys 
    1685                 1690                 1695             


Gly Lys  Phe Lys Phe Met Phe  Asn Ile Ala Asp Gly  Gly Phe Thr 
    1700                 1705                 1710             


Glu Leu  His Thr Leu Trp Gln  Asn Glu Glu Arg Ala  Ala Val Ser 
    1715                 1720                 1725             


Ser Gly  Lys Ile Tyr Asp Ile  Trp His Arg Arg His  Asp Tyr Trp 
    1730                 1735                 1740             


Leu Leu  Ala Gly Ile Val Thr  His Gly Tyr Ala Arg  Trp Gln Asp 
    1745                 1750                 1755             


Ile Gln  Asn Asp Pro Arg Tyr  Met Ile Leu Asn Glu  Pro Phe Lys 
    1760                 1765                 1770             


Ser Glu  Val His Lys Gly Asn  Tyr Leu Glu Met Lys  Asn Lys Phe 
    1775                 1780                 1785             


Leu Ala  Arg Arg Phe Lys Leu  Leu Glu Gln Ala Leu  Val Ile Glu 
    1790                 1795                 1800             


Glu Gln  Leu Arg Arg Ala Ala  Tyr Leu Asn Met Thr  Gln Asp Pro 
    1805                 1810                 1815             


Asn His  Pro Ala Met Ala Leu  Asn Ala Arg Leu Ala  Glu Val Glu 
    1820                 1825                 1830             


Cys Leu  Ala Glu Ser His Gln  His Leu Ser Lys Glu  Ser Leu Ala 
    1835                 1840                 1845             


Gly Asn  Lys Pro Ala Asn Ala  Val Leu His Lys Val  Leu Asn Gln 
    1850                 1855                 1860             


Leu Glu  Glu Leu Leu Ser Asp  Met Lys Ala Asp Val  Thr Arg Leu 
    1865                 1870                 1875             


Pro Ser  Met Leu Ser Arg Ile  Pro Pro Val Ala Ala  Arg Leu Gln 
    1880                 1885                 1890             


Met Ser  Glu Arg Ser Ile Leu  Ser Arg Leu Thr Asn  Arg Ala Gly 
    1895                 1900                 1905             


Asp Pro  Thr Ile Gln Gln Gly  Ala Phe Gly Ser Ser  Gln Met Tyr 
    1910                 1915                 1920             


Ser Asn  Asn Phe Gly Pro Asn  Phe Arg Gly Pro Gly  Pro Gly Gly 
    1925                 1930                 1935             


Ile Val  Asn Tyr Asn Gln Met  Pro Leu Gly Pro Tyr  Val Thr Asp 
    1940                 1945                 1950             


Ile 
    

<210>  3
<211>  2487
<212>  DNA
<213>  Homo sapiens

<400>  3
cctttcccct cccgccggac ctgccaggag gtgggctggc gcggagggag ggccctgtcc     60

cctgtccctt taaggaggag ggccaaacgc cggcctagag tgcggcgtag cccccacccg    120

ccgtgccctc accccagagc agctgcagcc tcagccggcc gcccctccgc cagccaagtc    180

cgccgctctg acccccggca gcaagtcgcc accatggtga agatcgtgac agttaagacc    240

caggcgtacc aggaccagaa gccgggcacg agcgggctgc ggaagcgggt gaaggtgttc    300

cagagcagcg ccaactacgc ggagaacttc atccagagta tcatctccac cgtggagccg    360

gcgcagcggc aggaggccac gctggtggtg ggcggggacg gccggttcta catgaaggag    420

gccatccagc tcatcgctcg catcgctgcc gccaacggga tcggtcgctt ggttatcgga    480

cagaatggaa tcctctccac ccctgctgta tcctgcatca ttagaaaaat caaagccatt    540

ggtgggatca ttctgacagc cagtcacaac ccagggggcc ccaatggaga ttttggaatc    600

aaattcaata tttctaatgg aggtcctgct ccagaagcaa taactgataa aattttccaa    660

atcagcaaga caattgaaga atatgcagtt tgccctgacc tgaaagtaga ccttggtgtt    720

ctgggaaagc agcagtttga cttggaaaat aagttcaaac ccttcacagt ggaaattgtg    780

gattcggtag aagcttatgc tacaatgctg agaagcatct ttgatttcag tgcactgaaa    840

gaactacttt ctgggccaaa ccgactgaag atccgtattg atgctatgca tggagttgtg    900

ggaccgtatg taaagaagat cctctgtgaa gaactcggtg cccctgcgaa ctcggcagtt    960

aactgcgttc ctctggagga ctttggaggc caccaccctg accccaacct cacctatgca   1020

gctgacctgg tggagaccat gaagtcagga gagcatgatt ttggggctgc ctttgatgga   1080

gatggggatc gaaacatgat tctgggcaag catgggttct ttgtgaaccc ttcagactct   1140

gtggctgtca ttgctgccaa catcttcagc attccgtatt tccagcagac tggggtccgc   1200

ggctttgcac ggagcatgcc cacgagtggt gctctggacc gggtggctag tgctacaaag   1260

attgctttgt atgagacccc aactggctgg aagttttttg ggaatttgat ggacgcgagc   1320

aaactgtccc tttgtgggga ggagagcttc gggaccggtt ctgaccacat ccgtgagaaa   1380

gatggactgt gggctgtcct tgcctggctc tccatcctag ccacccgcaa gcagagtgtg   1440

gaggacattc tcaaagatca ttggcaaaag tatggccgga atttcttcac caggtatgat   1500

tacgaggagg tggaagctga gggcgcaaac aaaatgatga aggacttgga ggccctgatg   1560

tttgatcgct cctttgtggg gaagcagttc tcagcaaatg acaaagttta cactgtggag   1620

aaggccgata actttgaata cagcgaccca gtggatggaa gcatttcaag aaatcagggc   1680

ttgcgcctca ttttcacaga tggttctcga atcgtcttcc gactgagcgg cactgggagt   1740

gccggggcca ccattcggct gtacatcgat agctatgaga aggacgttgc caagattaac   1800

caggaccccc aggtcatgtt ggcccccctt atttccattg ctctgaaagt gtcccagctg   1860

caggagagga cgggacgcac tgcacccact gtcatcacct aagaagacag gcctgatgtg   1920

gtacgtccct ccacccccgg acccatccaa gtcatctgat tgaagagcat gacagaaaca   1980

aaatgtattc accaagcatt ttaggatttg actttttcac taaccagttg acgagcagtg   2040

catttacaag gcactgccaa acaagatgcc cttgggagct gtgagggaaa gaggacctgc   2100

gggcttagat caatctcaat tccttttcat gccctcctgc attgctgctg cgtgggtatt   2160

tgtctcctta gccatcaggt acagtttaca ctacaatgta agctataggt ggagcatcag   2220

cagtgagtga ggccattctt catccttagg atgtggcaat gaaatgatgg tgcaagttcc   2280

tttctctttt gtgaatcttt ccccccattt cctgtttaca tgtaacccaa caaaatgcaa   2340

tttctagtgc cttctgtcca atcagttctt tcctctgagt gagacgtact tggctacaga   2400

tttctgcctt gttttgcgac attgtcccat tcacacagat attttgggat aataaaggaa   2460

aataagctac aaaaaaaaaa aaaaaaa                                       2487


<210>  4
<211>  562
<212>  PRT
<213>  Homo sapiens

<400>  4


Met Val Lys Ile Val Thr Val Lys Thr Gln Ala Tyr Gln Asp Gln Lys 
1               5                   10                  15      


Pro Gly Thr Ser Gly Leu Arg Lys Arg Val Lys Val Phe Gln Ser Ser 
            20                  25                  30          


Ala Asn Tyr Ala Glu Asn Phe Ile Gln Ser Ile Ile Ser Thr Val Glu 
        35                  40                  45              


Pro Ala Gln Arg Gln Glu Ala Thr Leu Val Val Gly Gly Asp Gly Arg 
    50                  55                  60                  


Phe Tyr Met Lys Glu Ala Ile Gln Leu Ile Ala Arg Ile Ala Ala Ala 
65                  70                  75                  80  


Asn Gly Ile Gly Arg Leu Val Ile Gly Gln Asn Gly Ile Leu Ser Thr 
                85                  90                  95      


Pro Ala Val Ser Cys Ile Ile Arg Lys Ile Lys Ala Ile Gly Gly Ile 
            100                 105                 110         


Ile Leu Thr Ala Ser His Asn Pro Gly Gly Pro Asn Gly Asp Phe Gly 
        115                 120                 125             


Ile Lys Phe Asn Ile Ser Asn Gly Gly Pro Ala Pro Glu Ala Ile Thr 
    130                 135                 140                 


Asp Lys Ile Phe Gln Ile Ser Lys Thr Ile Glu Glu Tyr Ala Val Cys 
145                 150                 155                 160 


Pro Asp Leu Lys Val Asp Leu Gly Val Leu Gly Lys Gln Gln Phe Asp 
                165                 170                 175     


Leu Glu Asn Lys Phe Lys Pro Phe Thr Val Glu Ile Val Asp Ser Val 
            180                 185                 190         


Glu Ala Tyr Ala Thr Met Leu Arg Ser Ile Phe Asp Phe Ser Ala Leu 
        195                 200                 205             


Lys Glu Leu Leu Ser Gly Pro Asn Arg Leu Lys Ile Arg Ile Asp Ala 
    210                 215                 220                 


Met His Gly Val Val Gly Pro Tyr Val Lys Lys Ile Leu Cys Glu Glu 
225                 230                 235                 240 


Leu Gly Ala Pro Ala Asn Ser Ala Val Asn Cys Val Pro Leu Glu Asp 
                245                 250                 255     


Phe Gly Gly His His Pro Asp Pro Asn Leu Thr Tyr Ala Ala Asp Leu 
            260                 265                 270         


Val Glu Thr Met Lys Ser Gly Glu His Asp Phe Gly Ala Ala Phe Asp 
        275                 280                 285             


Gly Asp Gly Asp Arg Asn Met Ile Leu Gly Lys His Gly Phe Phe Val 
    290                 295                 300                 


Asn Pro Ser Asp Ser Val Ala Val Ile Ala Ala Asn Ile Phe Ser Ile 
305                 310                 315                 320 


Pro Tyr Phe Gln Gln Thr Gly Val Arg Gly Phe Ala Arg Ser Met Pro 
                325                 330                 335     


Thr Ser Gly Ala Leu Asp Arg Val Ala Ser Ala Thr Lys Ile Ala Leu 
            340                 345                 350         


Tyr Glu Thr Pro Thr Gly Trp Lys Phe Phe Gly Asn Leu Met Asp Ala 
        355                 360                 365             


Ser Lys Leu Ser Leu Cys Gly Glu Glu Ser Phe Gly Thr Gly Ser Asp 
    370                 375                 380                 


His Ile Arg Glu Lys Asp Gly Leu Trp Ala Val Leu Ala Trp Leu Ser 
385                 390                 395                 400 


Ile Leu Ala Thr Arg Lys Gln Ser Val Glu Asp Ile Leu Lys Asp His 
                405                 410                 415     


Trp Gln Lys Tyr Gly Arg Asn Phe Phe Thr Arg Tyr Asp Tyr Glu Glu 
            420                 425                 430         


Val Glu Ala Glu Gly Ala Asn Lys Met Met Lys Asp Leu Glu Ala Leu 
        435                 440                 445             


Met Phe Asp Arg Ser Phe Val Gly Lys Gln Phe Ser Ala Asn Asp Lys 
    450                 455                 460                 


Val Tyr Thr Val Glu Lys Ala Asp Asn Phe Glu Tyr Ser Asp Pro Val 
465                 470                 475                 480 


Asp Gly Ser Ile Ser Arg Asn Gln Gly Leu Arg Leu Ile Phe Thr Asp 
                485                 490                 495     


Gly Ser Arg Ile Val Phe Arg Leu Ser Gly Thr Gly Ser Ala Gly Ala 
            500                 505                 510         


Thr Ile Arg Leu Tyr Ile Asp Ser Tyr Glu Lys Asp Val Ala Lys Ile 
        515                 520                 525             


Asn Gln Asp Pro Gln Val Met Leu Ala Pro Leu Ile Ser Ile Ala Leu 
    530                 535                 540                 


Lys Val Ser Gln Leu Gln Glu Arg Thr Gly Arg Thr Ala Pro Thr Val 
545                 550                 555                 560 


Ile Thr 
        

<210>  5
<211>  2303
<212>  DNA
<213>  Homo sapiens

<400>  5
gttgagcgag agagggagcg tggagagctg gagcagccgc caccgccgcc gccgagggag     60

ccccgggacg gcagcccctg ggcgcagggt gcgctgttct cggagtccga cccagggcga    120

ctcacgccca ctggtgcgac ccggacagcc tgggactgac ccgccggccc aggcgaggct    180

gcagccagag ggctgggaag ggatcgcgct cgcggcatcc agaggcggcc aggcggaggc    240

gagggagcag gttagaggga caaagagctt tgcagacgtc cccggcgtcc tgcgagcgcc    300

agcggccggg acgaggcggc cgggagcccg ggaagagccc gtggatgttc tgcgcgcggc    360

ctgggagccg ccgccgccgc cgcctcagcg agaggaggaa tgcaccggcc gcgccgccgc    420

gggacgcgcc cgccgctcct ggcgctgctg gccgcgctgc tgctggccgc acgcggggct    480

gctgcccaag aaacagagct gtcagtcagt gctgaattag tgcctacctc atcatggaac    540

atctcaagtg aactcaacaa agattcttac ctgaccctcg atgaaccaat gaataacatc    600

accacgtctc tgggccagac agcagaactg cactgcaaag tctctgggaa tccacctccc    660

accatccgct ggttcaaaaa tgatgctcct gtggtccagg agccccggag gctctccttt    720

cggtccacca tctatggctc tcggctgcgg attagaaacc tcgacaccac agacacaggc    780

tacttccagt gcgtggcaac aaacggcaag gaggtggttt cttccactgg agtcttgttt    840

gtcaagtttg gcccccctcc cactgcaagt ccaggatact cagatgagta tgaagaagat    900

ggattctgtc agccatacag agggattgca tgtgcaagat ttattggcaa ccgcaccgtc    960

tatatggagt ctttgcacat gcaaggggaa atagaaaatc agatcacagc tgccttcact   1020

atgattggca cttccagtca cttatctgat aagtgttctc agttcgccat tccttccctg   1080

tgccactatg ccttcccgta ctgcgatgaa acttcatccg tcccaaagcc ccgtgacttg   1140

tgtcgcgatg aatgtgaaat cctggagaat gtcctgtgtc aaacagagta catttttgca   1200

agatcaaatc ccatgattct gatgaggctg aaactgccaa actgtgaaga tctcccccag   1260

ccagagagcc cagaagctgc gaactgtatc cggattggaa ttcccatggc agatcctata   1320

aataaaaatc acaagtgtta taacagcaca ggtgtggact accgggggac cgtcagtgtg   1380

accaaatcag ggcgccagtg ccagccatgg aattcccagt atccccacac acacactttc   1440

accgcccttc gtttcccaga gctgaatgga ggccattcct actgccgcaa cccagggaat   1500

caaaaggaag ctccctggtg cttcaccttg gatgaaaact ttaagtctga tctgtgtgac   1560

atcccagcgt gcggtaaata gaagtcattg cccctaatgt attcaatcat ctttaaagat   1620

ccctatccta cccctcttat ttaggagaat cctataaggg gggcaaagaa aatggacagt   1680

atttgcttga tctcaatctg gttttagggt aaaccttgcc gtttctacat aaaacacctc   1740

gtaaggtacc aaaacacgtt ctcaagaagt caactgcctt tatacctgca gccattgcac   1800

tcatggatgt aacagggacc cagcccttca gaggcacagt tgagacagtt tatcacattg   1860

atttttatag aaaaagatgt tacccagaat ggtctgcgtc caagtggacc ttttcagcaa   1920

aaaaaggaat attggaagca ggaagaaatt gttttctgta tgccttaaga acaccacaag   1980

gcaggatgaa tctacaacca ttactcggtc atccaggaca atctgtgggt aaactgtgtc   2040

cttcgttatg tctgttaata ctgcagaaga agcatatagg tatctagtaa gaaaatggaa   2100

ttcctgagtc agttaactgt tcctttttct agaaaatgtt tggagaaaat aatgaaaatg   2160

ggccaagcat ggtggcttat acctgtaatc ccaacactct aggaaggccg aggcaggagg   2220

atcatttgag cccaggggtt caagaccagc ccaggcaaca tagtgagact ccatctctac   2280

caaaaaaaag aaaaaaaaaa aaa                                           2303


<210>  6
<211>  393
<212>  PRT
<213>  Homo sapiens

<400>  6


Met His Arg Pro Arg Arg Arg Gly Thr Arg Pro Pro Leu Leu Ala Leu 
1               5                   10                  15      


Leu Ala Ala Leu Leu Leu Ala Ala Arg Gly Ala Ala Ala Gln Glu Thr 
            20                  25                  30          


Glu Leu Ser Val Ser Ala Glu Leu Val Pro Thr Ser Ser Trp Asn Ile 
        35                  40                  45              


Ser Ser Glu Leu Asn Lys Asp Ser Tyr Leu Thr Leu Asp Glu Pro Met 
    50                  55                  60                  


Asn Asn Ile Thr Thr Ser Leu Gly Gln Thr Ala Glu Leu His Cys Lys 
65                  70                  75                  80  


Val Ser Gly Asn Pro Pro Pro Thr Ile Arg Trp Phe Lys Asn Asp Ala 
                85                  90                  95      


Pro Val Val Gln Glu Pro Arg Arg Leu Ser Phe Arg Ser Thr Ile Tyr 
            100                 105                 110         


Gly Ser Arg Leu Arg Ile Arg Asn Leu Asp Thr Thr Asp Thr Gly Tyr 
        115                 120                 125             


Phe Gln Cys Val Ala Thr Asn Gly Lys Glu Val Val Ser Ser Thr Gly 
    130                 135                 140                 


Val Leu Phe Val Lys Phe Gly Pro Pro Pro Thr Ala Ser Pro Gly Tyr 
145                 150                 155                 160 


Ser Asp Glu Tyr Glu Glu Asp Gly Phe Cys Gln Pro Tyr Arg Gly Ile 
                165                 170                 175     


Ala Cys Ala Arg Phe Ile Gly Asn Arg Thr Val Tyr Met Glu Ser Leu 
            180                 185                 190         


His Met Gln Gly Glu Ile Glu Asn Gln Ile Thr Ala Ala Phe Thr Met 
        195                 200                 205             


Ile Gly Thr Ser Ser His Leu Ser Asp Lys Cys Ser Gln Phe Ala Ile 
    210                 215                 220                 


Pro Ser Leu Cys His Tyr Ala Phe Pro Tyr Cys Asp Glu Thr Ser Ser 
225                 230                 235                 240 


Val Pro Lys Pro Arg Asp Leu Cys Arg Asp Glu Cys Glu Ile Leu Glu 
                245                 250                 255     


Asn Val Leu Cys Gln Thr Glu Tyr Ile Phe Ala Arg Ser Asn Pro Met 
            260                 265                 270         


Ile Leu Met Arg Leu Lys Leu Pro Asn Cys Glu Asp Leu Pro Gln Pro 
        275                 280                 285             


Glu Ser Pro Glu Ala Ala Asn Cys Ile Arg Ile Gly Ile Pro Met Ala 
    290                 295                 300                 


Asp Pro Ile Asn Lys Asn His Lys Cys Tyr Asn Ser Thr Gly Val Asp 
305                 310                 315                 320 


Tyr Arg Gly Thr Val Ser Val Thr Lys Ser Gly Arg Gln Cys Gln Pro 
                325                 330                 335     


Trp Asn Ser Gln Tyr Pro His Thr His Thr Phe Thr Ala Leu Arg Phe 
            340                 345                 350         


Pro Glu Leu Asn Gly Gly His Ser Tyr Cys Arg Asn Pro Gly Asn Gln 
        355                 360                 365             


Lys Glu Ala Pro Trp Cys Phe Thr Leu Asp Glu Asn Phe Lys Ser Asp 
    370                 375                 380                 


Leu Cys Asp Ile Pro Ala Cys Gly Lys 
385                 390             

<210>  7
<211>  3382
<212>  DNA
<213>  Homo sapiens

<400>  7
gttgagcgag agagggagcg tggagagctg gagcagccgc caccgccgcc gccgagggag     60

ccccgggacg gcagcccctg ggcgcagggt gcgctgttct cggagtccga cccagggcga    120

ctcacgccca ctggtgcgac ccggacagcc tgggactgac ccgccggccc aggcgaggct    180

gcagccagag ggctgggaag ggatcgcgct cgcggcatcc agaggcggcc aggcggaggc    240

gagggagcag gttagaggga caaagagctt tgcagacgtc cccggcgtcc tgcgagcgcc    300

agcggccggg acgaggcggc cgggagcccg ggaagagccc gtggatgttc tgcgcgcggc    360

ctgggagccg ccgccgccgc cgcctcagcg agaggaggaa tgcaccggcc gcgccgccgc    420

gggacgcgcc cgccgctcct ggcgctgctg gccgcgctgc tgctggccgc acgcggggct    480

gctgcccaag aaacagagct gtcagtcagt gctgaattag tgcctacctc atcatggaac    540

atctcaagtg aactcaacaa agattcttac ctgaccctcg atgaaccaat gaataacatc    600

accacgtctc tgggccagac agcagaactg cactgcaaag tctctgggaa tccacctccc    660

accatccgct ggttcaaaaa tgatgctcct gtggtccagg agccccggag gctctccttt    720

cggtccacca tctatggctc tcggctgcgg attagaaacc tcgacaccac agacacaggc    780

tacttccagt gcgtggcaac aaacggcaag gaggtggttt cttccactgg agtcttgttt    840

gtcaagtttg gcccccctcc cactgcaagt ccaggatact cagatgagta tgaagaagat    900

ggattctgtc agccatacag agggattgca tgtgcaagat ttattggcaa ccgcaccgtc    960

tatatggagt ctttgcacat gcaaggggaa atagaaaatc agatcacagc tgccttcact   1020

atgattggca cttccagtca cttatctgat aagtgttctc agttcgccat tccttccctg   1080

tgccactatg ccttcccgta ctgcgatgaa acttcatccg tcccaaagcc ccgtgacttg   1140

tgtcgcgatg aatgtgaaat cctggagaat gtcctgtgtc aaacagagta catttttgca   1200

agatcaaatc ccatgattct gatgaggctg aaactgccaa actgtgaaga tctcccccag   1260

ccagagagcc cagaagctgc gaactgtatc cggattggaa ttcccatggc agatcctata   1320

aataaaaatc acaagtgtta taacagcaca ggtgtggact accgggggac cgtcagtgtg   1380

accaaatcag ggcgccagtg ccagccatgg aattcccagt atccccacac acacactttc   1440

accgcccttc gtttcccaga gctgaatgga ggccattcct actgccgcaa cccagggaat   1500

caaaaggaag ctccctggtg cttcaccttg gatgaaaact ttaagtctga tctgtgtgac   1560

atcccagcgt gcgattcaaa ggattccaag gagaagaata aaatggaaat cctgtacata   1620

ctagtgccaa gtgtggccat tcccctggcc attgctttac tcttcttctt catttgcgtc   1680

tgtcggaata accagaagtc atcgtcggca ccagtccaga ggcaaccaaa acacgtcaga   1740

ggtcaaaatg tagagatgtc aatgctgaat gcatataaac ccaagagcaa ggctaaagag   1800

ctacctcttt ctgctgtacg ctttatggaa gaattgggtg agtgtgcctt tggaaaaatc   1860

tataaaggcc atctctatct cccaggcatg gaccatgctc agctggttgc tatcaagacc   1920

ttgaaagact ataacaaccc ccagcaatgg acggaatttc aacaagaagc ctccctaatg   1980

gcagaactgc accaccccaa tattgtctgc cttctaggtg ccgtcactca ggaacaacct   2040

gtgtgcatgc tttttgagta tattaatcag ggggatctcc atgagttcct catcatgaga   2100

tccccacact ctgatgttgg ctgcagcagt gatgaagatg ggactgtgaa atccagcctg   2160

gaccacggag attttctgca cattgcaatt cagattgcag ctggcatgga atacctgtct   2220

agtcacttct ttgtccacaa ggaccttgca gctcgcaata ttttaatcgg agagcaactt   2280

catgtaaaga tttcagactt ggggctttcc agagaaattt actccgctga ttactacagg   2340

gtccagagta agtccttgct gcccattcgc tggatgcccc ctgaagccat catgtatggc   2400

aaattctctt ctgattcaga tatctggtcc tttggggttg tcttgtggga gattttcagt   2460

tttggactcc agccatatta tggattcagt aaccaggaag tgattgagat ggtgagaaaa   2520

cggcagctct taccatgctc tgaagactgc ccacccagaa tgtacagcct catgacagag   2580

tgctggaatg agattccttc taggagacca agatttaaag atattcacgt ccggcttcgg   2640

tcctgggagg gactctcaag tcacacaagc tctactactc cttcaggggg aaatgccacc   2700

acacagacaa cctccctcag tgccagccca gtgagtaatc tcagtaaccc cagatatcct   2760

aattacatgt tcccgagcca gggtattaca ccacagggcc agattgctgg tttcattggc   2820

ccgccaatac ctcagaacca gcgattcatt cccatcaatg gatacccaat acctcctgga   2880

tatgcagcgt ttccagctgc ccactaccag ccaacaggtc ctcccagagt gattcagcac   2940

tgcccacctc ccaagagtcg gtccccaagc agtgccagtg ggtcgactag cactggccat   3000

gtgactagct tgccctcatc aggatccaat caggaagcaa atattccttt actaccacac   3060

atgtcaattc caaatcatcc tggtggaatg ggtatcaccg tttttggcaa caaatctcaa   3120

aaaccctaca aaattgactc aaagcaagca tctttactag gagacgccaa tattcatgga   3180

cacaccgaat ctatgatttc tgcagaactg taaaatgcac aacttttgta aatgtggtat   3240

acaggacaaa ctagacggcc gtagaaaaga tttatattca aatgttttta ttaaagtaag   3300

gttctcattt agcagacatc gcaacaagta ccttctgtga agtttcactg tgtcttacca   3360

agcaggacag acactcggcc ag                                            3382


<210>  8
<211>  937
<212>  PRT
<213>  Homo sapiens

<400>  8


Met His Arg Pro Arg Arg Arg Gly Thr Arg Pro Pro Leu Leu Ala Leu 
1               5                   10                  15      


Leu Ala Ala Leu Leu Leu Ala Ala Arg Gly Ala Ala Ala Gln Glu Thr 
            20                  25                  30          


Glu Leu Ser Val Ser Ala Glu Leu Val Pro Thr Ser Ser Trp Asn Ile 
        35                  40                  45              


Ser Ser Glu Leu Asn Lys Asp Ser Tyr Leu Thr Leu Asp Glu Pro Met 
    50                  55                  60                  


Asn Asn Ile Thr Thr Ser Leu Gly Gln Thr Ala Glu Leu His Cys Lys 
65                  70                  75                  80  


Val Ser Gly Asn Pro Pro Pro Thr Ile Arg Trp Phe Lys Asn Asp Ala 
                85                  90                  95      


Pro Val Val Gln Glu Pro Arg Arg Leu Ser Phe Arg Ser Thr Ile Tyr 
            100                 105                 110         


Gly Ser Arg Leu Arg Ile Arg Asn Leu Asp Thr Thr Asp Thr Gly Tyr 
        115                 120                 125             


Phe Gln Cys Val Ala Thr Asn Gly Lys Glu Val Val Ser Ser Thr Gly 
    130                 135                 140                 


Val Leu Phe Val Lys Phe Gly Pro Pro Pro Thr Ala Ser Pro Gly Tyr 
145                 150                 155                 160 


Ser Asp Glu Tyr Glu Glu Asp Gly Phe Cys Gln Pro Tyr Arg Gly Ile 
                165                 170                 175     


Ala Cys Ala Arg Phe Ile Gly Asn Arg Thr Val Tyr Met Glu Ser Leu 
            180                 185                 190         


His Met Gln Gly Glu Ile Glu Asn Gln Ile Thr Ala Ala Phe Thr Met 
        195                 200                 205             


Ile Gly Thr Ser Ser His Leu Ser Asp Lys Cys Ser Gln Phe Ala Ile 
    210                 215                 220                 


Pro Ser Leu Cys His Tyr Ala Phe Pro Tyr Cys Asp Glu Thr Ser Ser 
225                 230                 235                 240 


Val Pro Lys Pro Arg Asp Leu Cys Arg Asp Glu Cys Glu Ile Leu Glu 
                245                 250                 255     


Asn Val Leu Cys Gln Thr Glu Tyr Ile Phe Ala Arg Ser Asn Pro Met 
            260                 265                 270         


Ile Leu Met Arg Leu Lys Leu Pro Asn Cys Glu Asp Leu Pro Gln Pro 
        275                 280                 285             


Glu Ser Pro Glu Ala Ala Asn Cys Ile Arg Ile Gly Ile Pro Met Ala 
    290                 295                 300                 


Asp Pro Ile Asn Lys Asn His Lys Cys Tyr Asn Ser Thr Gly Val Asp 
305                 310                 315                 320 


Tyr Arg Gly Thr Val Ser Val Thr Lys Ser Gly Arg Gln Cys Gln Pro 
                325                 330                 335     


Trp Asn Ser Gln Tyr Pro His Thr His Thr Phe Thr Ala Leu Arg Phe 
            340                 345                 350         


Pro Glu Leu Asn Gly Gly His Ser Tyr Cys Arg Asn Pro Gly Asn Gln 
        355                 360                 365             


Lys Glu Ala Pro Trp Cys Phe Thr Leu Asp Glu Asn Phe Lys Ser Asp 
    370                 375                 380                 


Leu Cys Asp Ile Pro Ala Cys Asp Ser Lys Asp Ser Lys Glu Lys Asn 
385                 390                 395                 400 


Lys Met Glu Ile Leu Tyr Ile Leu Val Pro Ser Val Ala Ile Pro Leu 
                405                 410                 415     


Ala Ile Ala Leu Leu Phe Phe Phe Ile Cys Val Cys Arg Asn Asn Gln 
            420                 425                 430         


Lys Ser Ser Ser Ala Pro Val Gln Arg Gln Pro Lys His Val Arg Gly 
        435                 440                 445             


Gln Asn Val Glu Met Ser Met Leu Asn Ala Tyr Lys Pro Lys Ser Lys 
    450                 455                 460                 


Ala Lys Glu Leu Pro Leu Ser Ala Val Arg Phe Met Glu Glu Leu Gly 
465                 470                 475                 480 


Glu Cys Ala Phe Gly Lys Ile Tyr Lys Gly His Leu Tyr Leu Pro Gly 
                485                 490                 495     


Met Asp His Ala Gln Leu Val Ala Ile Lys Thr Leu Lys Asp Tyr Asn 
            500                 505                 510         


Asn Pro Gln Gln Trp Thr Glu Phe Gln Gln Glu Ala Ser Leu Met Ala 
        515                 520                 525             


Glu Leu His His Pro Asn Ile Val Cys Leu Leu Gly Ala Val Thr Gln 
    530                 535                 540                 


Glu Gln Pro Val Cys Met Leu Phe Glu Tyr Ile Asn Gln Gly Asp Leu 
545                 550                 555                 560 


His Glu Phe Leu Ile Met Arg Ser Pro His Ser Asp Val Gly Cys Ser 
                565                 570                 575     


Ser Asp Glu Asp Gly Thr Val Lys Ser Ser Leu Asp His Gly Asp Phe 
            580                 585                 590         


Leu His Ile Ala Ile Gln Ile Ala Ala Gly Met Glu Tyr Leu Ser Ser 
        595                 600                 605             


His Phe Phe Val His Lys Asp Leu Ala Ala Arg Asn Ile Leu Ile Gly 
    610                 615                 620                 


Glu Gln Leu His Val Lys Ile Ser Asp Leu Gly Leu Ser Arg Glu Ile 
625                 630                 635                 640 


Tyr Ser Ala Asp Tyr Tyr Arg Val Gln Ser Lys Ser Leu Leu Pro Ile 
                645                 650                 655     


Arg Trp Met Pro Pro Glu Ala Ile Met Tyr Gly Lys Phe Ser Ser Asp 
            660                 665                 670         


Ser Asp Ile Trp Ser Phe Gly Val Val Leu Trp Glu Ile Phe Ser Phe 
        675                 680                 685             


Gly Leu Gln Pro Tyr Tyr Gly Phe Ser Asn Gln Glu Val Ile Glu Met 
    690                 695                 700                 


Val Arg Lys Arg Gln Leu Leu Pro Cys Ser Glu Asp Cys Pro Pro Arg 
705                 710                 715                 720 


Met Tyr Ser Leu Met Thr Glu Cys Trp Asn Glu Ile Pro Ser Arg Arg 
                725                 730                 735     


Pro Arg Phe Lys Asp Ile His Val Arg Leu Arg Ser Trp Glu Gly Leu 
            740                 745                 750         


Ser Ser His Thr Ser Ser Thr Thr Pro Ser Gly Gly Asn Ala Thr Thr 
        755                 760                 765             


Gln Thr Thr Ser Leu Ser Ala Ser Pro Val Ser Asn Leu Ser Asn Pro 
    770                 775                 780                 


Arg Tyr Pro Asn Tyr Met Phe Pro Ser Gln Gly Ile Thr Pro Gln Gly 
785                 790                 795                 800 


Gln Ile Ala Gly Phe Ile Gly Pro Pro Ile Pro Gln Asn Gln Arg Phe 
                805                 810                 815     


Ile Pro Ile Asn Gly Tyr Pro Ile Pro Pro Gly Tyr Ala Ala Phe Pro 
            820                 825                 830         


Ala Ala His Tyr Gln Pro Thr Gly Pro Pro Arg Val Ile Gln His Cys 
        835                 840                 845             


Pro Pro Pro Lys Ser Arg Ser Pro Ser Ser Ala Ser Gly Ser Thr Ser 
    850                 855                 860                 


Thr Gly His Val Thr Ser Leu Pro Ser Ser Gly Ser Asn Gln Glu Ala 
865                 870                 875                 880 


Asn Ile Pro Leu Leu Pro His Met Ser Ile Pro Asn His Pro Gly Gly 
                885                 890                 895     


Met Gly Ile Thr Val Phe Gly Asn Lys Ser Gln Lys Pro Tyr Lys Ile 
            900                 905                 910         


Asp Ser Lys Gln Ala Ser Leu Leu Gly Asp Ala Asn Ile His Gly His 
        915                 920                 925             


Thr Glu Ser Met Ile Ser Ala Glu Leu 
    930                 935         

<210>  9
<211>  1567
<212>  DNA
<213>  Homo sapiens

<400>  9
gtcgtcacag catgatcata ttttttcacc cttcacttct ccttttacac aaatagcccc     60

ggatatctgt gttaccagcc ttgtctcggc cacctcaagg ataatcacta aattctgccg    120

aaaggactga ggaacggtgc ctggaaaagg gcaagaatat cacggcatgg gcatgagtag    180

cttgaaactg ctgaagtatg tcctgttttt cttcaacttg ctcttttgga tctgtggctg    240

ctgcattttg ggctttggga tctacctgct gatccacaac aacttcggag tgctcttcca    300

taacctcccc tccctcacgc tgggcaatgt gtttgtcatc gtgggctcta ttatcatggt    360

agttgccttc ctgggctgca tgggctctat caaggaaaac aagtgtctgc ttatgtcgtt    420

cttcatcctg ctgctgatta tcctccttgc tgaggtgacc ttggccatcc tgctctttgt    480

atatgaacag aagctgaatg agtatgtggc taagggtctg accgacagca tccaccgtta    540

ccactcagac aatagcacca aggcagcgtg ggactccatc cagtcatttc tgcagtgttg    600

tggtataaat ggcacgagtg attggaccag tggcccacca gcatcttgcc cctcagatcg    660

aaaagtggag ggttgctatg cgaaagcaag actgtggttt cattccaatt tcctgtatat    720

cggaatcatc accatctgtg tatgtgtgat tgaggtgttg gggatgtcct ttgcactgac    780

cctgaactgc cagattgaca aaaccagcca gaccataggg ctatgatctg cagtagtcct    840

gtggtgaaga gacttgtttc atctccggaa atgcaaaacc atttatagca tgaagcccta    900

catgatcact gcaggatgat cctcctccca tcctttccct ttttaggtcc ctgtcttata    960

caaccagaga agtgggtgtt ggccaggcac atcccatctc aggcagcaag acaatctttc   1020

actcactgac ggcagcagcc atgtctctca aagtggtgaa actaatatct gagcatcttt   1080

tagacaagag aggcaaagac aaactggatt taatggccca acatcaaagg gtgaacccag   1140

gatatgaatt tttgcatctt cccattgtcg aattagtctc cagcctctaa ataatgccca   1200

gtcttctccc caaagtcaag caagagacta gttgaaggga gttctggggc caggctcact   1260

ggaccattgt cacaaccctc tgtttctctt tgactaagtg ccctggctac aggaattaca   1320

cagttctctt tctccaaagg gcaagatctc atttcaattt ctttattaga gggccttatt   1380

gatgtgttct aagtctttcc agaaaaaaac tatccagtga tttatatcct gatttcaacc   1440

agtcacttag ctgataatca cagtaagaag acttctggta ttatctctct atcagataag   1500

attttgttaa tgtactattt tactcttcaa taaataaaag tttattatct caatcacaac   1560

attgcta                                                             1567


<210>  10
<211>  219
<212>  PRT
<213>  Homo sapiens

<400>  10


Met Gly Met Ser Ser Leu Lys Leu Leu Lys Tyr Val Leu Phe Phe Phe 
1               5                   10                  15      


Asn Leu Leu Phe Trp Ile Cys Gly Cys Cys Ile Leu Gly Phe Gly Ile 
            20                  25                  30          


Tyr Leu Leu Ile His Asn Asn Phe Gly Val Leu Phe His Asn Leu Pro 
        35                  40                  45              


Ser Leu Thr Leu Gly Asn Val Phe Val Ile Val Gly Ser Ile Ile Met 
    50                  55                  60                  


Val Val Ala Phe Leu Gly Cys Met Gly Ser Ile Lys Glu Asn Lys Cys 
65                  70                  75                  80  


Leu Leu Met Ser Phe Phe Ile Leu Leu Leu Ile Ile Leu Leu Ala Glu 
                85                  90                  95      


Val Thr Leu Ala Ile Leu Leu Phe Val Tyr Glu Gln Lys Leu Asn Glu 
            100                 105                 110         


Tyr Val Ala Lys Gly Leu Thr Asp Ser Ile His Arg Tyr His Ser Asp 
        115                 120                 125             


Asn Ser Thr Lys Ala Ala Trp Asp Ser Ile Gln Ser Phe Leu Gln Cys 
    130                 135                 140                 


Cys Gly Ile Asn Gly Thr Ser Asp Trp Thr Ser Gly Pro Pro Ala Ser 
145                 150                 155                 160 


Cys Pro Ser Asp Arg Lys Val Glu Gly Cys Tyr Ala Lys Ala Arg Leu 
                165                 170                 175     


Trp Phe His Ser Asn Phe Leu Tyr Ile Gly Ile Ile Thr Ile Cys Val 
            180                 185                 190         


Cys Val Ile Glu Val Leu Gly Met Ser Phe Ala Leu Thr Leu Asn Cys 
        195                 200                 205             


Gln Ile Asp Lys Thr Ser Gln Thr Ile Gly Leu 
    210                 215                 

<210>  11
<211>  1572
<212>  DNA
<213>  Homo sapiens

<400>  11
gaggacagac tgaagaaaca tccaaggtgg tcttgaagga cactgggatc ctgtaacaca     60

gccccggata tctgtgttac cagccttgtc tcggccacct caaggataat cactaaattc    120

tgccgaaagg actgaggaac ggtgcctgga aaagggcaag aatatcacgg catgggcatg    180

agtagcttga aactgctgaa gtatgtcctg tttttcttca acttgctctt ttggatctgt    240

ggctgctgca ttttgggctt tgggatctac ctgctgatcc acaacaactt cggagtgctc    300

ttccataacc tcccctccct cacgctgggc aatgtgtttg tcatcgtggg ctctattatc    360

atggtagttg ccttcctggg ctgcatgggc tctatcaagg aaaacaagtg tctgcttatg    420

tcgttcttca tcctgctgct gattatcctc cttgctgagg tgaccttggc catcctgctc    480

tttgtatatg aacagaagct gaatgagtat gtggctaagg gtctgaccga cagcatccac    540

cgttaccact cagacaatag caccaaggca gcgtgggact ccatccagtc atttctgcag    600

tgttgtggta taaatggcac gagtgattgg accagtggcc caccagcatc ttgcccctca    660

gatcgaaaag tggagggttg ctatgcgaaa gcaagactgt ggtttcattc caatttcctg    720

tatatcggaa tcatcaccat ctgtgtatgt gtgattgagg tgttggggat gtcctttgca    780

ctgaccctga actgccagat tgacaaaacc agccagacca tagggctatg atctgcagta    840

gtcctgtggt gaagagactt gtttcatctc cggaaatgca aaaccattta tagcatgaag    900

ccctacatga tcactgcagg atgatcctcc tcccatcctt tcccttttta ggtccctgtc    960

ttatacaacc agagaagtgg gtgttggcca ggcacatccc atctcaggca gcaagacaat   1020

ctttcactca ctgacggcag cagccatgtc tctcaaagtg gtgaaactaa tatctgagca   1080

tcttttagac aagagaggca aagacaaact ggatttaatg gcccaacatc aaagggtgaa   1140

cccaggatat gaatttttgc atcttcccat tgtcgaatta gtctccagcc tctaaataat   1200

gcccagtctt ctccccaaag tcaagcaaga gactagttga agggagttct ggggccaggc   1260

tcactggacc attgtcacaa ccctctgttt ctctttgact aagtgccctg gctacaggaa   1320

ttacacagtt ctctttctcc aaagggcaag atctcatttc aatttcttta ttagagggcc   1380

ttattgatgt gttctaagtc tttccagaaa aaaactatcc agtgatttat atcctgattt   1440

caaccagtca cttagctgat aatcacagta agaagacttc tggtattatc tctctatcag   1500

ataagatttt gttaatgtac tattttactc ttcaataaat aaaagtttat tatctcaatc   1560

acaacattgc ta                                                       1572


<210>  12
<211>  219
<212>  PRT
<213>  Homo sapiens

<400>  12


Met Gly Met Ser Ser Leu Lys Leu Leu Lys Tyr Val Leu Phe Phe Phe 
1               5                   10                  15      


Asn Leu Leu Phe Trp Ile Cys Gly Cys Cys Ile Leu Gly Phe Gly Ile 
            20                  25                  30          


Tyr Leu Leu Ile His Asn Asn Phe Gly Val Leu Phe His Asn Leu Pro 
        35                  40                  45              


Ser Leu Thr Leu Gly Asn Val Phe Val Ile Val Gly Ser Ile Ile Met 
    50                  55                  60                  


Val Val Ala Phe Leu Gly Cys Met Gly Ser Ile Lys Glu Asn Lys Cys 
65                  70                  75                  80  


Leu Leu Met Ser Phe Phe Ile Leu Leu Leu Ile Ile Leu Leu Ala Glu 
                85                  90                  95      


Val Thr Leu Ala Ile Leu Leu Phe Val Tyr Glu Gln Lys Leu Asn Glu 
            100                 105                 110         


Tyr Val Ala Lys Gly Leu Thr Asp Ser Ile His Arg Tyr His Ser Asp 
        115                 120                 125             


Asn Ser Thr Lys Ala Ala Trp Asp Ser Ile Gln Ser Phe Leu Gln Cys 
    130                 135                 140                 


Cys Gly Ile Asn Gly Thr Ser Asp Trp Thr Ser Gly Pro Pro Ala Ser 
145                 150                 155                 160 


Cys Pro Ser Asp Arg Lys Val Glu Gly Cys Tyr Ala Lys Ala Arg Leu 
                165                 170                 175     


Trp Phe His Ser Asn Phe Leu Tyr Ile Gly Ile Ile Thr Ile Cys Val 
            180                 185                 190         


Cys Val Ile Glu Val Leu Gly Met Ser Phe Ala Leu Thr Leu Asn Cys 
        195                 200                 205             


Gln Ile Asp Lys Thr Ser Gln Thr Ile Gly Leu 
    210                 215                 

<210>  13
<211>  4538
<212>  DNA
<213>  Homo sapiens

<400>  13
tggtgtgggg agacgctggt cctccccgtc ctcccatagc gcttattgcc tcaccctcac     60

cccctagggg ccggatccaa aggcgctgca ctccccaagc cttggggcat cagccaggaa    120

ggtttcctac ctcctaattc aggggcagga ctcctctttt ccccccacgg ggaaaagagg    180

cagaaactta ggggtttccc tcctttctta gggtcagacg ctcttagggt ccacttcttc    240

aggggcggaa gcctctccta cccttcccat aggggcacag gcctttaccc cactgtactt    300

cggagccaac gcctttccct cagcactgcc accccagagt caggacccag aggactgtgc    360

cttcgccccc aacgcaggcg cggccttttg gagaggaggg aggagtggag aggacagggg    420

cccttgctct cccctcccca acttgttcct cttgcccccc agtccctggc aatccagaga    480

tcccgatatc taggactgtc catccatcca ctccctgacc ttttcccggc tcctggctgc    540

agccatggag ttgcagaagg gaaaaggggc ggcagcagca gcagctgctt cgggagcagc    600

gggaggtgga ggaggaggag cgggagcagg agccccagga ggggggaggc tgctactttc    660

aaccagtttg gatgccaagg atgagttaga ggagagattg gaaaggtgta tgagcattgt    720

gacatcgatg actgctggtg tctcggagag agaagccaat gatgccctca atgcgtatgt    780

gtgcaaaggc ctcccccagc atgaagaaat ctgcctgggc ctgtttactc tcatcctcac    840

tgaacctgcc caagcccaga agtgttaccg ggacttagct ctggtgagtc gtgatggcat    900

gaatattgtc ctgaataaaa tcaaccagat acttatggag aagtacctga agctgcagga    960

tacctgccgt actcagttgg tgtggttggt acgggaactg gtgaagagtg gggttctggg   1020

agccgatggt gtttgtatga cgtttatgaa gcagattgca ggtggagatg ttacagccaa   1080

aaatatctgg ttggcagaaa gtgttctgga tatcctgaca gagcaaaggg agtgggtcct   1140

gaagagcagc atcctcattg ccatggctgt ttacacgtac ctccgcctca tcgtggacca   1200

ccatgggact gcccagctcc aggccctgcg acagaaggaa gtagacttct gcatctcact   1260

gcttcgggaa cggttcatgg aatgtctgat gattggtcgg gatctcgtaa gactacttca   1320

gaatgttgct aggataccag aatttgaact gctttggaaa gatattatcc ataatcctca   1380

ggccttgagt cctcagttca caggtatcct acagcttctt cagtcaagaa catcccgaaa   1440

attcctagca tgtcgtctaa ccccggacat ggagactaaa ctcctcttca tgacatcccg   1500

ggtgcgattt ggtcaacaaa agcgatacca agattggttc cagcgccagt acctgtcaac   1560

tccagatagt cagtctctgc gctgtgacct cattcgctac atctgtgggg tagtccaccc   1620

ttctaatgaa gtactgagtt cagatatctt gccccggtgg gccatcattg gttggctcct   1680

gacaacgtgc acgtcaaatg tcgctgcctc caatgccaag ctggctttgt tttatgactg   1740

gctgttcttt agtccagaca aggatagcat tatgaacata gaaccagcca tcctggtcat   1800

gcaccactcc atgaagcccc acccagccat cactgccaca ctcctggact tcatgtgccg   1860

catcattccc aacttctatc caccattgga gggccacgtg cggcagggtg tcttttcctc   1920

cctcaaccac attgtggaga aacgggtctt ggcacaccta gctcccctgt ttgacaaccc   1980

taagttggat aaggagctgc gggcaatgct gagagagaag tttcctgagt tctgcagctc   2040

accctcccca cctgtggaag tcaaaattga ggagccagtt tccatggaga tggacaacca   2100

tatgtcggat aaggatgaga gttgctatga caatgcagag gcagccttca gtgacgatga   2160

agaggatctc aacagcaaag gaaagaagag ggagtttcgc ttccacccta tcaaggagac   2220

agttgtggag gagccagttg atatcacccc ttaccttgac cagttggatg agtccctgag   2280

ggacaaagta ctccagctac agaaggggag tgatacggag gcccagtgtg aggtcatgca   2340

ggaaattgtg gaccaggtcc tggaggaaga ctttgactcg gagcagctgt ctgtccttgc   2400

ttcctgccta caggagctct tcaaggccca ctttcgaggg gaggtcctgc ctgaggagat   2460

tactgaggag tccctggagg agtctgtagg aaagcctctg tacctaatat ttaggaacct   2520

atgtcagatg caggaagaca acagcagctt ctctctactt ctagaccttc tctccgagct   2580

atatcagaag cagcccaaga ttggctacca cctgctctac tacctgaggg ccagcaaagc   2640

cgccgcaggg aagatgaacc tgtacgagtc atttgcccag gctacccagc tgggcgatct   2700

gcacacctgc ctgatgatgg acatgaaggc ctgccaggag gacgatgtgc ggctcctgtg   2760

ccacctcacg ccctccatct acacagagtt tccagatgaa accttgagga gcggagagct   2820

gctgaacatg atcgtggctg ttattgactc tgcacagctc caggagctgg tctgccacgt   2880

gatgatgggt aacctggtta tgtttcgaaa agactcagtt ctcaacatac tcattcagag   2940

cctagactgg gagacctttg agcagtattg tgcctggcag ctctttctgg cccacaatat   3000

tcccctggag accataatcc ccatcctgca gcacctcaaa tacaaggagc acccagaggc   3060

cctgtcctgc ctactgcttc aactccgaag agaaaagccc agcgaggaga tggtgaagat   3120

ggtgctgagc cggccctgcc atcctgacga ccagttcacc accagcatcc tgcggcactg   3180

gtgcatgaaa catgacgagc tgctggccga gcacatcaag tccctgctca tcaagaacaa   3240

cagcctgcct cgcaagagac agagcctgag gagctctagc agcaagctgg cccagctgac   3300

tctggagcag atcctggagc acttggacaa tctgcggctc aacctgacca acaccaagca   3360

gaactttttt agccagacgc caattctcca ggcgctgcag catgtccaag cgagctgtga   3420

cgaagcccac aagatgaaat tcagtgatct cttctccctg gcggaggaat atgaggactc   3480

ttccaccaag ccacccaaga gccggcgaaa agcagctctg tccagccctc gaagtcgaaa   3540

gaatgccaca cagcccccca atgccgaaga agagtcgggc tccagcagtg cttcagaaga   3600

ggaagacacg aaaccgaagc ctaccaagcg gaaacgaaaa gggtcctctg cagtgggctc   3660

tgacagtgac tgaggccctg cattccccat cccacccccg gctggactgc cctctccttc   3720

ttggtgattc aaaggttaat agaggctgag gagattgcag gggaaacacc cttgctgcat   3780

ccccaagctc ccccggtgga aggaggagct ttctcctctg gctgagtttg agaagctgcc   3840

atgcagcccc tagccccttc cctcctcctg gggcctccag cccctcacac tgctgttccc   3900

agtgatattt gggatctgac tgaagccaga ggctctgtaa aatcagacca tagtggaagt   3960

cctcagcccc ctggcccctt ccgcaatctc ctcccccagt ctcccaaaga gccatttcaa   4020

cagagaaggg aaatgacaaa ggggcagctg gccagataag ctaggatgag agcagagact   4080

cagtgtgtgg gtgtcccttc ctgcttcccc ttcaggtctt ggtttgttct gaagggacgt   4140

tttatagtca ctatccacat gccagtgtga aatgggcatc tatgacgtgg tcagggtgtc   4200

cattcctaat catggggcag atgccacaag cattcagaaa ggagtctgaa agggtggcca   4260

cagccccacg tggtgtgccc tggaggctta ggttggtctg aggttggcac ctcaatctac   4320

accagagccc agggagtccc agaggcaagt ttcacagaat tgtcaaatga tcccatttcc   4380

ttgagtctgt tttttttttt gttttttttt gttttttttt tggcagagat aatcgtgtct   4440

taaaagttgt ttttaaatga caataaaaca agccagaatg tcaaaaaaaa aaaaaaaaaa   4500

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa                           4538


<210>  14
<211>  1042
<212>  PRT
<213>  Homo sapiens

<400>  14


Met Glu Leu Gln Lys Gly Lys Gly Ala Ala Ala Ala Ala Ala Ala Ser 
1               5                   10                  15      


Gly Ala Ala Gly Gly Gly Gly Gly Gly Ala Gly Ala Gly Ala Pro Gly 
            20                  25                  30          


Gly Gly Arg Leu Leu Leu Ser Thr Ser Leu Asp Ala Lys Asp Glu Leu 
        35                  40                  45              


Glu Glu Arg Leu Glu Arg Cys Met Ser Ile Val Thr Ser Met Thr Ala 
    50                  55                  60                  


Gly Val Ser Glu Arg Glu Ala Asn Asp Ala Leu Asn Ala Tyr Val Cys 
65                  70                  75                  80  


Lys Gly Leu Pro Gln His Glu Glu Ile Cys Leu Gly Leu Phe Thr Leu 
                85                  90                  95      


Ile Leu Thr Glu Pro Ala Gln Ala Gln Lys Cys Tyr Arg Asp Leu Ala 
            100                 105                 110         


Leu Val Ser Arg Asp Gly Met Asn Ile Val Leu Asn Lys Ile Asn Gln 
        115                 120                 125             


Ile Leu Met Glu Lys Tyr Leu Lys Leu Gln Asp Thr Cys Arg Thr Gln 
    130                 135                 140                 


Leu Val Trp Leu Val Arg Glu Leu Val Lys Ser Gly Val Leu Gly Ala 
145                 150                 155                 160 


Asp Gly Val Cys Met Thr Phe Met Lys Gln Ile Ala Gly Gly Asp Val 
                165                 170                 175     


Thr Ala Lys Asn Ile Trp Leu Ala Glu Ser Val Leu Asp Ile Leu Thr 
            180                 185                 190         


Glu Gln Arg Glu Trp Val Leu Lys Ser Ser Ile Leu Ile Ala Met Ala 
        195                 200                 205             


Val Tyr Thr Tyr Leu Arg Leu Ile Val Asp His His Gly Thr Ala Gln 
    210                 215                 220                 


Leu Gln Ala Leu Arg Gln Lys Glu Val Asp Phe Cys Ile Ser Leu Leu 
225                 230                 235                 240 


Arg Glu Arg Phe Met Glu Cys Leu Met Ile Gly Arg Asp Leu Val Arg 
                245                 250                 255     


Leu Leu Gln Asn Val Ala Arg Ile Pro Glu Phe Glu Leu Leu Trp Lys 
            260                 265                 270         


Asp Ile Ile His Asn Pro Gln Ala Leu Ser Pro Gln Phe Thr Gly Ile 
        275                 280                 285             


Leu Gln Leu Leu Gln Ser Arg Thr Ser Arg Lys Phe Leu Ala Cys Arg 
    290                 295                 300                 


Leu Thr Pro Asp Met Glu Thr Lys Leu Leu Phe Met Thr Ser Arg Val 
305                 310                 315                 320 


Arg Phe Gly Gln Gln Lys Arg Tyr Gln Asp Trp Phe Gln Arg Gln Tyr 
                325                 330                 335     


Leu Ser Thr Pro Asp Ser Gln Ser Leu Arg Cys Asp Leu Ile Arg Tyr 
            340                 345                 350         


Ile Cys Gly Val Val His Pro Ser Asn Glu Val Leu Ser Ser Asp Ile 
        355                 360                 365             


Leu Pro Arg Trp Ala Ile Ile Gly Trp Leu Leu Thr Thr Cys Thr Ser 
    370                 375                 380                 


Asn Val Ala Ala Ser Asn Ala Lys Leu Ala Leu Phe Tyr Asp Trp Leu 
385                 390                 395                 400 


Phe Phe Ser Pro Asp Lys Asp Ser Ile Met Asn Ile Glu Pro Ala Ile 
                405                 410                 415     


Leu Val Met His His Ser Met Lys Pro His Pro Ala Ile Thr Ala Thr 
            420                 425                 430         


Leu Leu Asp Phe Met Cys Arg Ile Ile Pro Asn Phe Tyr Pro Pro Leu 
        435                 440                 445             


Glu Gly His Val Arg Gln Gly Val Phe Ser Ser Leu Asn His Ile Val 
    450                 455                 460                 


Glu Lys Arg Val Leu Ala His Leu Ala Pro Leu Phe Asp Asn Pro Lys 
465                 470                 475                 480 


Leu Asp Lys Glu Leu Arg Ala Met Leu Arg Glu Lys Phe Pro Glu Phe 
                485                 490                 495     


Cys Ser Ser Pro Ser Pro Pro Val Glu Val Lys Ile Glu Glu Pro Val 
            500                 505                 510         


Ser Met Glu Met Asp Asn His Met Ser Asp Lys Asp Glu Ser Cys Tyr 
        515                 520                 525             


Asp Asn Ala Glu Ala Ala Phe Ser Asp Asp Glu Glu Asp Leu Asn Ser 
    530                 535                 540                 


Lys Gly Lys Lys Arg Glu Phe Arg Phe His Pro Ile Lys Glu Thr Val 
545                 550                 555                 560 


Val Glu Glu Pro Val Asp Ile Thr Pro Tyr Leu Asp Gln Leu Asp Glu 
                565                 570                 575     


Ser Leu Arg Asp Lys Val Leu Gln Leu Gln Lys Gly Ser Asp Thr Glu 
            580                 585                 590         


Ala Gln Cys Glu Val Met Gln Glu Ile Val Asp Gln Val Leu Glu Glu 
        595                 600                 605             


Asp Phe Asp Ser Glu Gln Leu Ser Val Leu Ala Ser Cys Leu Gln Glu 
    610                 615                 620                 


Leu Phe Lys Ala His Phe Arg Gly Glu Val Leu Pro Glu Glu Ile Thr 
625                 630                 635                 640 


Glu Glu Ser Leu Glu Glu Ser Val Gly Lys Pro Leu Tyr Leu Ile Phe 
                645                 650                 655     


Arg Asn Leu Cys Gln Met Gln Glu Asp Asn Ser Ser Phe Ser Leu Leu 
            660                 665                 670         


Leu Asp Leu Leu Ser Glu Leu Tyr Gln Lys Gln Pro Lys Ile Gly Tyr 
        675                 680                 685             


His Leu Leu Tyr Tyr Leu Arg Ala Ser Lys Ala Ala Ala Gly Lys Met 
    690                 695                 700                 


Asn Leu Tyr Glu Ser Phe Ala Gln Ala Thr Gln Leu Gly Asp Leu His 
705                 710                 715                 720 


Thr Cys Leu Met Met Asp Met Lys Ala Cys Gln Glu Asp Asp Val Arg 
                725                 730                 735     


Leu Leu Cys His Leu Thr Pro Ser Ile Tyr Thr Glu Phe Pro Asp Glu 
            740                 745                 750         


Thr Leu Arg Ser Gly Glu Leu Leu Asn Met Ile Val Ala Val Ile Asp 
        755                 760                 765             


Ser Ala Gln Leu Gln Glu Leu Val Cys His Val Met Met Gly Asn Leu 
    770                 775                 780                 


Val Met Phe Arg Lys Asp Ser Val Leu Asn Ile Leu Ile Gln Ser Leu 
785                 790                 795                 800 


Asp Trp Glu Thr Phe Glu Gln Tyr Cys Ala Trp Gln Leu Phe Leu Ala 
                805                 810                 815     


His Asn Ile Pro Leu Glu Thr Ile Ile Pro Ile Leu Gln His Leu Lys 
            820                 825                 830         


Tyr Lys Glu His Pro Glu Ala Leu Ser Cys Leu Leu Leu Gln Leu Arg 
        835                 840                 845             


Arg Glu Lys Pro Ser Glu Glu Met Val Lys Met Val Leu Ser Arg Pro 
    850                 855                 860                 


Cys His Pro Asp Asp Gln Phe Thr Thr Ser Ile Leu Arg His Trp Cys 
865                 870                 875                 880 


Met Lys His Asp Glu Leu Leu Ala Glu His Ile Lys Ser Leu Leu Ile 
                885                 890                 895     


Lys Asn Asn Ser Leu Pro Arg Lys Arg Gln Ser Leu Arg Ser Ser Ser 
            900                 905                 910         


Ser Lys Leu Ala Gln Leu Thr Leu Glu Gln Ile Leu Glu His Leu Asp 
        915                 920                 925             


Asn Leu Arg Leu Asn Leu Thr Asn Thr Lys Gln Asn Phe Phe Ser Gln 
    930                 935                 940                 


Thr Pro Ile Leu Gln Ala Leu Gln His Val Gln Ala Ser Cys Asp Glu 
945                 950                 955                 960 


Ala His Lys Met Lys Phe Ser Asp Leu Phe Ser Leu Ala Glu Glu Tyr 
                965                 970                 975     


Glu Asp Ser Ser Thr Lys Pro Pro Lys Ser Arg Arg Lys Ala Ala Leu 
            980                 985                 990         


Ser Ser Pro Arg Ser Arg Lys Asn  Ala Thr Gln Pro Pro  Asn Ala Glu 
        995                 1000                 1005             


Glu Glu  Ser Gly Ser Ser Ser  Ala Ser Glu Glu Glu  Asp Thr Lys 
    1010                 1015                 1020             


Pro Lys  Pro Thr Lys Arg Lys  Arg Lys Gly Ser Ser  Ala Val Gly 
    1025                 1030                 1035             


Ser Asp  Ser Asp 
    1040         

<210>  15
<211>  2430
<212>  DNA
<213>  Homo sapiens

<400>  15
cacacccgca ctcctcccgg gtttctgctc tccgcccgtg tggagtggtg ggggcctggg     60

tgggaatggg cgtgtgccag cgcacgcgcg ctccctggaa ggagaagtct cagctagaac    120

gagcggccct aggttttcgg aagggaggat cagggatgtt tgcgagcggc tggaaccaga    180

cggtgccgat agaggaagcg ggctccatgg ctgccctcct gctgctgccc ctgctgctgt    240

tgctaccgct gctgctgctg aagctacacc tctggccgca gttgcgctgg cttccggcgg    300

acttggcctt tgcggtgcga gctctgtgct gcaaaagggc tcttcgagct cgcgccctgg    360

ccgcggctgc cgccgacccg gaaggtcccg aggggggctg cagcctggcc tggcgcctcg    420

cggaactggc ccagcagcgc gccgcgcaca cctttctcat tcacggctcg cggcgcttta    480

gctactcaga ggcggagcgc gagagtaaca gggctgcacg cgccttccta cgtgcgctag    540

gctgggactg gggacccgac ggcggcgaca gcggcgaggg gagcgctgga gaaggcgagc    600

gggcagcgcc gggagccgga gatgcagcgg ccggaagcgg cgcggagttt gccggagggg    660

acggtgccgc cagaggtgga ggagccgccg cccctctgtc acctggagca actgtggcgc    720

tgctcctccc cgctggccca gagtttctgt ggctctggtt cgggctggcc aaggccggcc    780

tgcgcactgc ctttgtgccc accgccctgc gccggggccc cctgctgcac tgcctccgca    840

gctgcggcgc gcgcgcgctg gtgctggcgc cagagtttct ggagtccctg gagccggacc    900

tgcccgccct gagagccatg gggctccacc tgtgggctgc aggcccagga acccaccctg    960

ctggaattag cgatttgctg gctgaagtgt ccgctgaagt ggatgggcca gtgccaggat   1020

acctctcttc cccccagagc ataacagaca cgtgcctgta catcttcacc tctggcacca   1080

cgggcctccc caaggctgct cggatcagtc atctgaagat cctgcaatgc cagggcttct   1140

atcagctgtg tggtgtccac caggaagatg tgatctacct cgccctccca ctctaccaca   1200

tgtccggttc cctgctgggc atcgtgggct gcatgggcat tggggccaca gtggtgctga   1260

aatccaagtt ctcggctggt cagttctggg aagattgcca gcagcacagg gtgacggtgt   1320

tccagtacat tggggagctg tgccgatacc ttgtcaacca gcccccgagc aaggcagaac   1380

gtggccataa ggtccggctg gcagtgggca gcgggctgcg cccagatacc tgggagcgtt   1440

ttgtgcggcg cttcgggccc ctgcaggtgc tggagacata tggactgaca gagggcaacg   1500

tggccaccat caactacaca ggacagcggg gcgctgtggg gcgtgcttcc tggctttaca   1560

agcatatctt ccccttctcc ttgattcgct atgatgtcac cacaggagag ccaattcggg   1620

acccccaggg gcactgtatg gccacatctc caggtgagcc agggctgctg gtggccccgg   1680

taagccagca gtccccattc ctgggctatg ctggcgggcc agagctggcc caggggaagt   1740

tgctaaagga tgtcttccgg cctggggatg ttttcttcaa cactggggac ctgctggtct   1800

gcgatgacca aggttttctc cgcttccatg atcgtactgg agacaccttc aggtggaagg   1860

gggagaatgt ggccacaacc gaggtggcag aggtcttcga ggccctagat tttcttcagg   1920

aggtgaacgt ctatggagtc actgtgccag ggcatgaagg cagggctgga atggcagccc   1980

tagttctgcg tcccccccac gctttggacc ttatgcagct ctacacccac gtgtctgaga   2040

acttgccacc ttatgcccgg ccccgattcc tcaggctcca ggagtctttg gccaccacag   2100

agaccttcaa acagcagaaa gttcggatgg caaatgaggg cttcgacccc agcaccctgt   2160

ctgacccact gtacgttctg gaccaggctg taggtgccta cctgcccctc acaactgccc   2220

ggtacagcgc cctcctggca ggaaaccttc gaatctgaga acttccacac ctgaggcacc   2280

tgagagagga actctgtggg gtgggggccg ttgcaggtgt actgggctgt cagggatctt   2340

ttctatacca gaactgcggt cactattttg taataaatgt ggctggagct gatccagctg   2400

tctctgacct acaaaaaaaa aaaaaaaaaa                                    2430


<210>  16
<211>  730
<212>  PRT
<213>  Homo sapiens

<400>  16


Met Gly Val Cys Gln Arg Thr Arg Ala Pro Trp Lys Glu Lys Ser Gln 
1               5                   10                  15      


Leu Glu Arg Ala Ala Leu Gly Phe Arg Lys Gly Gly Ser Gly Met Phe 
            20                  25                  30          


Ala Ser Gly Trp Asn Gln Thr Val Pro Ile Glu Glu Ala Gly Ser Met 
        35                  40                  45              


Ala Ala Leu Leu Leu Leu Pro Leu Leu Leu Leu Leu Pro Leu Leu Leu 
    50                  55                  60                  


Leu Lys Leu His Leu Trp Pro Gln Leu Arg Trp Leu Pro Ala Asp Leu 
65                  70                  75                  80  


Ala Phe Ala Val Arg Ala Leu Cys Cys Lys Arg Ala Leu Arg Ala Arg 
                85                  90                  95      


Ala Leu Ala Ala Ala Ala Ala Asp Pro Glu Gly Pro Glu Gly Gly Cys 
            100                 105                 110         


Ser Leu Ala Trp Arg Leu Ala Glu Leu Ala Gln Gln Arg Ala Ala His 
        115                 120                 125             


Thr Phe Leu Ile His Gly Ser Arg Arg Phe Ser Tyr Ser Glu Ala Glu 
    130                 135                 140                 


Arg Glu Ser Asn Arg Ala Ala Arg Ala Phe Leu Arg Ala Leu Gly Trp 
145                 150                 155                 160 


Asp Trp Gly Pro Asp Gly Gly Asp Ser Gly Glu Gly Ser Ala Gly Glu 
                165                 170                 175     


Gly Glu Arg Ala Ala Pro Gly Ala Gly Asp Ala Ala Ala Gly Ser Gly 
            180                 185                 190         


Ala Glu Phe Ala Gly Gly Asp Gly Ala Ala Arg Gly Gly Gly Ala Ala 
        195                 200                 205             


Ala Pro Leu Ser Pro Gly Ala Thr Val Ala Leu Leu Leu Pro Ala Gly 
    210                 215                 220                 


Pro Glu Phe Leu Trp Leu Trp Phe Gly Leu Ala Lys Ala Gly Leu Arg 
225                 230                 235                 240 


Thr Ala Phe Val Pro Thr Ala Leu Arg Arg Gly Pro Leu Leu His Cys 
                245                 250                 255     


Leu Arg Ser Cys Gly Ala Arg Ala Leu Val Leu Ala Pro Glu Phe Leu 
            260                 265                 270         


Glu Ser Leu Glu Pro Asp Leu Pro Ala Leu Arg Ala Met Gly Leu His 
        275                 280                 285             


Leu Trp Ala Ala Gly Pro Gly Thr His Pro Ala Gly Ile Ser Asp Leu 
    290                 295                 300                 


Leu Ala Glu Val Ser Ala Glu Val Asp Gly Pro Val Pro Gly Tyr Leu 
305                 310                 315                 320 


Ser Ser Pro Gln Ser Ile Thr Asp Thr Cys Leu Tyr Ile Phe Thr Ser 
                325                 330                 335     


Gly Thr Thr Gly Leu Pro Lys Ala Ala Arg Ile Ser His Leu Lys Ile 
            340                 345                 350         


Leu Gln Cys Gln Gly Phe Tyr Gln Leu Cys Gly Val His Gln Glu Asp 
        355                 360                 365             


Val Ile Tyr Leu Ala Leu Pro Leu Tyr His Met Ser Gly Ser Leu Leu 
    370                 375                 380                 


Gly Ile Val Gly Cys Met Gly Ile Gly Ala Thr Val Val Leu Lys Ser 
385                 390                 395                 400 


Lys Phe Ser Ala Gly Gln Phe Trp Glu Asp Cys Gln Gln His Arg Val 
                405                 410                 415     


Thr Val Phe Gln Tyr Ile Gly Glu Leu Cys Arg Tyr Leu Val Asn Gln 
            420                 425                 430         


Pro Pro Ser Lys Ala Glu Arg Gly His Lys Val Arg Leu Ala Val Gly 
        435                 440                 445             


Ser Gly Leu Arg Pro Asp Thr Trp Glu Arg Phe Val Arg Arg Phe Gly 
    450                 455                 460                 


Pro Leu Gln Val Leu Glu Thr Tyr Gly Leu Thr Glu Gly Asn Val Ala 
465                 470                 475                 480 


Thr Ile Asn Tyr Thr Gly Gln Arg Gly Ala Val Gly Arg Ala Ser Trp 
                485                 490                 495     


Leu Tyr Lys His Ile Phe Pro Phe Ser Leu Ile Arg Tyr Asp Val Thr 
            500                 505                 510         


Thr Gly Glu Pro Ile Arg Asp Pro Gln Gly His Cys Met Ala Thr Ser 
        515                 520                 525             


Pro Gly Glu Pro Gly Leu Leu Val Ala Pro Val Ser Gln Gln Ser Pro 
    530                 535                 540                 


Phe Leu Gly Tyr Ala Gly Gly Pro Glu Leu Ala Gln Gly Lys Leu Leu 
545                 550                 555                 560 


Lys Asp Val Phe Arg Pro Gly Asp Val Phe Phe Asn Thr Gly Asp Leu 
                565                 570                 575     


Leu Val Cys Asp Asp Gln Gly Phe Leu Arg Phe His Asp Arg Thr Gly 
            580                 585                 590         


Asp Thr Phe Arg Trp Lys Gly Glu Asn Val Ala Thr Thr Glu Val Ala 
        595                 600                 605             


Glu Val Phe Glu Ala Leu Asp Phe Leu Gln Glu Val Asn Val Tyr Gly 
    610                 615                 620                 


Val Thr Val Pro Gly His Glu Gly Arg Ala Gly Met Ala Ala Leu Val 
625                 630                 635                 640 


Leu Arg Pro Pro His Ala Leu Asp Leu Met Gln Leu Tyr Thr His Val 
                645                 650                 655     


Ser Glu Asn Leu Pro Pro Tyr Ala Arg Pro Arg Phe Leu Arg Leu Gln 
            660                 665                 670         


Glu Ser Leu Ala Thr Thr Glu Thr Phe Lys Gln Gln Lys Val Arg Met 
        675                 680                 685             


Ala Asn Glu Gly Phe Asp Pro Ser Thr Leu Ser Asp Pro Leu Tyr Val 
    690                 695                 700                 


Leu Asp Gln Ala Val Gly Ala Tyr Leu Pro Leu Thr Thr Ala Arg Tyr 
705                 710                 715                 720 


Ser Ala Leu Leu Ala Gly Asn Leu Arg Ile 
                725                 730 

<210>  17
<211>  2662
<212>  DNA
<213>  Homo sapiens

<400>  17
caggaacacg aaggcaagga cagtagcctt cagtctcgac cccagagctt ggcaccccag     60

aacctgggct ccccaaagca agaccagggc ccccacattg tgcgccaaag tgcggggtgg    120

agaatgccca cagcccaagg gcccccaggc tgaaggcagg agactggggc tgctggagaa    180

gttgcccagg ctgaggggcc gtgcctggca gggacatggg gctgctgctg ctgctgctcc    240

caggctgggg ctgtgctgca ggctccgagc tggccttcgt gcaggagctg ggggacacag    300

tggctgtgtg ggagcaccca ctggtgctgc cctgccaggt ggagggtgag ccgcctgtgt    360

ccatttcctg gcagcgggat aggctggcct tagccaatga gagtggtgtc accctgatgc    420

cagatggctc cctgcacctg gccgccctgc cttcccgccg gagcctccct tcccgtgccc    480

acgagtacca ctgcgtggcc cagaaccgct acgggcggct ggtgagccga caggcccggg    540

tacagctggc aagtctgtcc cgcttccacc aacatccaga atccattgag gtggagcggg    600

gtggagttgc tcgcttccag tgcctgatcc agggggtgcc tgagccatcc atttcctggg    660

agcacaatgg cacagccctg aatactgcca accaccgggt cacactgctg cctagtggca    720

tcctccacat caccagtgtg agccagactg acatgggaac ctaccgctgc gtggcatgga    780

atgtggccag tacccgccac agccaggatg cccagctgac cctgagtgtg ggacccctga    840

ggctgctgca ggagccagag atcctgtctg ggcctcagaa cctgaccctc acagtgcacc    900

agacggcagt gctggagtgc attgccacca gtcacccttg gccgcttgtc tcctggagcc    960

gcctggatgg ccgctccatc ggcgtagagg gcatccaagt tctggacatt ctggacacag   1020

ggaatctcat gatctccgac gtctcagtcc agcactcagg tgtctatgtc tgcgccgcca   1080

atcggccagg cacccatgtc cggcgcacag cgcagggcgt cctgctcgtg cagggtgagc   1140

cccaagggcc caactgggtg gggagagtgc tggagcaccc cagctccctg acaggagcct   1200

ggatctggag agggtccagg gcaggaggca agaggctggg tctcacggca ccttcctcca   1260

tgctattgcc tgcccagctc cccgagtttg tccagtggcc acagtccttg tccaagcctc   1320

cgggcagcag tgccatcttc acctgcgtgg cccagggcgt ccctgagtcc cgtctggtct   1380

ggctgaagaa tgggaaggtg ttgagtcctg ggaataacat caggctgact cacaacaata   1440

gtacgctgat gctggcaggg gtttcagttg aggatgaggc catctatcaa tgcgtggcag   1500

agaacagcac gggctccaac caggccagtg cccgcctggt tgtgacaggg ggcccagagc   1560

caccccgtcc ccaggggcct gcatgccatg gctctctcta cttctgccat tcgagtgtcc   1620

tgggagccac ccccccctcc agcagggaca tcattggcta cgtgctgcac ctccggcctg   1680

tgggagagcc atctggcccg gagctccaag aggccataag caaaggcact tctgagcacg   1740

tcttctccaa cctggagcct gccacagcct acaccatcca tttgcgggcc tactcagcag   1800

agggtgccag tcaggactct gctcccatct ttgcctccac catgggcagc aacctgggtg   1860

aggctctgaa ccttcctgtg ccactcaagg cctgcctttc tcagtgtgat cttgccccag   1920

aaccggctgc tctctatgac atcaagctgc aggcgttcaa tggcaatggg gatggaaata   1980

gcagtgcccg ctgtgtctca ttgtgtgatg tgcccctggc cactcctgat ggcacagtgt   2040

ccacagagtc caagactggg tgctcttgca gccagggtga gagcagccca ctgcctgggg   2100

ttgtggtggg catccacgtg ggcctggctg ccctcatcat ttgcctcctc tgcctcttcc   2160

tgggctggag acatagctaa gggccaggta agggctaatg tgggaaatct gccagggaga   2220

cagtctgcat cactgtggca cagggccaaa gagagcaaaa aagccccaat ctacaaccaa   2280

tcaattttac caatgaggag actcaggcag agagaggaag ccaattcttt tcagagctgt   2340

gtggtaccag gggcaggaga aggcctgcca tgagccggga agagagaact ggggctccca   2400

aagcaaagaa caagggcagc agaaatgagc tagagccagt tccctgccat ccagcagcat   2460

gaagaggggt ccaccctctc catctctggg gagcatggag caggaggagg ggttgggagc   2520

catgcgaggc agagggaggc accagacaga ccacactgct gacccttcct acccgggcag   2580

cctcctctgc aaacaggagt cccaggaatg ctgggcagtg cctcggactg cctcggacag   2640

aactgggggc catcaaggcc ag                                            2662


<210>  18
<211>  7480
<212>  DNA
<213>  Homo sapiens

<400>  18
agcgtccttg tttgtgtggt gccgccgccg ccggtgcagc cgtcgccgcc gccgctgccc     60

ccgtctgtac cgcagtgtct gctccgcccg cccgccccgg tccggcccgc ccccctcccc    120

tacccccgtc cctagtcccg tcagcagggt ctggatcccc tgtgccgtcg cctcttcctt    180

tttcgacgcc tccgccgccg cctgaggagg cgagctagcc gggagttaca ccgccaccgc    240

caggatggat agaatgacag aagatgctct tcgcttgaat ctgttgaagc ggagcttgga    300

cccagcagat gagcgagatg atgtcctggc aaagcgactc aaaatggagg ggcatgaggc    360

catggaacgt ctgaaaatgt tggcattgct caaaaggaag gatttggcaa atcttgaggt    420

gccacatgag ttacccacca aacaggatgg cagtggtgtc aagggctatg aagaaaaact    480

taacgggaat ctcaggcctc atggagacaa caggactgct ggaaggccag gcaaagaaaa    540

catcaatgat gagcctgtgg atatgagtgc tagacggagt gagccagagc gaggaaggct    600

aactccctca ccagacatca ttgttttgtc tgacaatgag gcttccagtc cccgttccag    660

ttccagaatg gaagaaagac tcaaagcagc caacttagag atgtttaagg ggaaaggcat    720

tgaggagcgg cagcagctta tcaagcagct gagggatgag ctacgattgg aagaagcccg    780

actggtcctg ttaaagaaac tgagacagag tcagctacag aaagagaatg tggtccagaa    840

gactccagtt gtacagaatg cagcatctat tgttcagcca tctcctgccc atgtgggaca    900

gcagggccta tctaagcttc cctctcggcc tggggcccaa ggggttgaac ctcaaaattt    960

gagaacatta cagggtcaca gtgtcatccg ttcagctacc aataccaccc ttccacacat   1020

gttgatgtct caacgtgtta ttgcaccaaa cccagcccag ctacagggtc agcggggccc   1080

gcctaagcct ggccttgtac gcaccacaac acccaacatg aatcccgcca tcaattatca   1140

accgcagtca agttcttctg ttccatgtca gcgtacaaca tcctctgcca tctatatgaa   1200

ccttgcttct catatccagc cagggacggt gaacagagtg tcctcgccac ttcctagccc   1260

cagcgccatg actgatgctg ccaactcaca ggctgcagcc aaattggctc ttcgcaaaca   1320

gctggaaaag acactcctgg agatcccacc ccctaaacct cctgctccct tacttcattt   1380

cttgcctagt gcagccaata gcgagttcat ctacatggta ggcttggaag aagtcgtaca   1440

gagtgtcatt gacagccaag gcaaaagctg tgcctcactt ctgcgggttg aaccctttgt   1500

atgtgcccag tgccgcacag atttcacccc tcactggaag caagaaaaga atggtaagat   1560

tctatgtgag cagtgtatga cctccaacca gaaaaaggct ctaaaagctg aacacaccaa   1620

ccggctgaaa aatgcatttg tgaaagccct acagcaggaa caggaaattg aacagcgatt   1680

acagcagcag gcagccctct cccccactac ggctccagct gtgtccagtg tcagtaaaca   1740

agagaccatc atgagacatc atacgcttcg gcaggctcca cagccccaga gcagcctcca   1800

gcgtggcata cccacatctg cccgctccat gctttcaaac tttgcacagg caccccagtt   1860

gtctgtgcca ggtggcctcc ttggtatgcc aggtgtcaac attgcatact tgaatactgg   1920

catcggagga cacaaaggcc ccagtttggc agaccgacag cgtgaatacc ttttagacat   1980

gatccctccc cggtctatat cgcagtccat cagtggacag aaataacgcc tgttccactt   2040

gtactgcccc atccttgaat cctttatccc tttcctcttt cattccccca acttctgtcg   2100

catgcagtgc ctgtactggt gcctaccata cacggaaagc aaaacagaaa aacagaagac   2160

aaaaaataga gatcagcaag aaaacacacg ccctgccctg ccacctcccc tttatttcac   2220

actgctgcga tctgttcttc tgccgctctg tcttctctct tcagttttct ttaacagtga   2280

ggtggatctt tacctctgat agaggtcaga atgaggtcct ggggagaatc taagccctcc   2340

gatgtgtgtt tctaaagttg ttttatgcta taattattac catttttaat gatgttgtgt   2400

gtcctccctt tgttcagtgg acggttaaac cttcccccac tcaaccaatc tttttctttt   2460

tccttttctt cctttttttt tttttttttt gtaaacacaa atgacattca gttcaatgat   2520

acgagcattg cagattgcag taggggtccc agctgccaag taggacatga ctaggagtgt   2580

taggggcaga agttttgaat gcacttaacc ggaggagggc gcagggtggg gggtatcaaa   2640

gaaggacgaa tagcacccta cctgtgggtg tttgggggct ggacaatttg ggtggcagtg   2700

tttggtactg aagttgggct ctaagaatga ggggaaagag cctggggagg agcttaaaac   2760

tcaaccactc tggaatttac ccatagaaga cgggaagaaa gaggtatgaa gatgggctca   2820

attatgagcc agggaggatt gaaactaggt cctgcctttc tgtatcttgg ggaaataaga   2880

ccgatctcct gaccccattg ggaacacgga agtctattcc aggccaacca gcccaaaatt   2940

atttcatctt gtattctttg taaaattctc cctcacccca ccctgctttt aaaaattcta   3000

atctatcccc tctaaccata gccccatcta taatacagag gaacggctgt tccaaggctg   3060

tttgctgggt gtcccacaag ttgggtggac ataaatgagt caagtgacaa caggaggaaa   3120

tagacttaga cgaaagaaag gatttctctt ccaacagttg agattcgcat atttgcctat   3180

tctttcaccc tctgagtgcc aggagatgag aggctggggg tacacaatca ggttggagtc   3240

ctgtccttac tctgctgcac cagctgcaga accaactgct caaagccaaa cagctcatgg   3300

caaaaccagc ttaggacctc tgctgtacaa atagttgctt cccactgccc cccgcccgcc   3360

cccagaatga tattaatttt gccttttttt tttttttttt tttaagcgct actaatgtag   3420

agaatgaatt gaattgtgca atgttgctgt tctggggact ggggagatta gcatcccatt   3480

tgcccacact gtgggaagac ggagtggacc aggctgtttt tgaagtaagg gaagcccctt   3540

aaaggtacgg gtttctgctc ttctcatagt gtacacccac ctgcctctct ggctccagaa   3600

gctgccagag tgcactgggg ggaatgttct cagcagagaa gaatgaggag aagtttaata   3660

ttttgccctt gaaagtcacc tgaggaagtt tccccacttt tattttttaa aattaagtaa   3720

ttttttaaag aaggcacttt taaaattaac acacacatga actgcacacc ttccccataa   3780

aatttggagg tggggtggga gaaagagcta aaatcaggct cagttcccct actctggcct   3840

ctactcccca caccccagtg ccactgtggg tgactatact ggccctacgg gccttcctgg   3900

cttttttctt tcctccctta ccccaaattc attgagcact taaaggagca gagatgcagc   3960

cagtgtctgg gctcccccag tggtgaaatg atctggaagc tagatgctag taacaggtag   4020

tgattgggtt ttttgagtat ttttccgggg aatgtggtac ccctgactgt aagtggtggg   4080

agagggaggg gggttaatgg aactgggtct gggattattt taaaattata tatatatata   4140

taaagatata ttcttacatc ttttctttgc cctctgtgct ttgaaagcac tggataaatt   4200

gtttggtttt gcttttctct cttccacaaa attggaagct ttttttaaaa atgttttccc   4260

cacaagtcat cttgccttgt ggcatgtctg tctagcctct tcctccctcc ctcatgatga   4320

agtgccattt ctgttacgtc tccctctccc caagctcaga ggtgctcaga ggtacgagat   4380

gcccaagttt gtcagttgag attaaaagta aggaacagag aatgtgcaat accgtctggc   4440

tgggggctgt ccctgccctg ccctgagctg agtcctttcc ctgggagcca ggccacctta   4500

gaatggggtt tggaagtaag atgtatagag ttggggaatc atggagaagg aaagcctata   4560

gtcgagtgcc tgcttaggtg ctgaggtcac aggggagatg gtggaatctt ccctgttttt   4620

atcccctcag ggtcagttac atagaagctg cttcttgact agtatagctc ggtgaccctt   4680

tgttcaaccg ctgaggtttg atttcttacc ctttcttctc cccattttca tactcttccc   4740

agggattagt gatggaggtg aggtctccct aatcatggta aagtgttaac cttccacctc   4800

ctcccttccc tcctccttcc tcatccttct gtcttcctca attctccgtc tctttttttt   4860

catcactgat tgccttgtgt ccctccaagt ctacttgtta ctatccatct ccaggctctg   4920

ggccgtgtag acactaaacc tcatgcccta aggacaggag gaaagaccct ctgtttggag   4980

cattattagt agagtgagga tcccaccagt tctgcctggc ttcctccatc cccagaggca   5040

ctaaaagcag tattttaagg ttggtgtctt actccctgga agcctgaaat gggtggaata   5100

gcggtaaggc ttgagtaaaa ctaggggaca gaggttctta tttgtcgatt ttattttata   5160

atttgaccac agcatctgaa ctccctctct ccctggaata agtatttttc ccacattttt   5220

ggatatatgt atggtagaca attttttttt aagacacaga gataaatgtt ttcctgcttt   5280

ggttaccttt cctttcccct ttaaaaggaa ttagctatag aactgctttg taaagatgct   5340

tcttgatatt ttacttttgt tccttttccc taatcattcc cttttctccc cactcctcca   5400

gaaggcataa cccttctctc cacaccccct acccccaccc ccgtcctagg ctcccatcct   5460

ttccatcaag accttcatta gcttatgata tttgctgccg agatgttata acaaggactc   5520

gttcatgtat ataagctatt tcttgatcca tttaaaagga attgtacatt gtgtagaaaa   5580

aaaaaaaaac ctgaaaaaga gaaaaaaaag ccctagccat ggatattgtg aaactgtgtt   5640

atgtcatttt gtaatgtgcc cgtttgtgta tgatccgtgc aaaagggttt ctggggaagg   5700

ggagggggta gggaggcagg gctgtggagg gtgggtaggg gagtgggccg ggcccagcac   5760

actgagactg gcagctgctc caaccccatc cctccttaga gatgccacct cccccaccac   5820

ccacccctaa tttgtgcctt gcctccccac cctggagtag tccctccggg tcaccagcac   5880

tgccttggca gagcccactc cctaccctaa cctgcccacc ctccctatcc cccagcatta   5940

ggttgatact gtggggaagt gctgggggct gggaggtagc cgaggaatgg ggcagttccc   6000

gggggcatcg aaaccaagta ttattatgaa ttgtaattgt atttgcactg tttttttcct   6060

ctgattgcat cagcatatat acaatatacc tatataacaa aattcagtgt caagctttct   6120

tatgcaaggg atttccccca ccccacctcc tcaaaaaaga aagaacctag tcttatgggc   6180

ctttgagggt ggattgtcag gggatgatag aaaggatttt aataagtcat cctgaggaaa   6240

tttcacctag tgagagccac atccatctgc acagccttag gctgcgtgaa ccgaggtgag   6300

gctgagctcc tgtgaaagcc aagacctcct ggtccaggac tttgtagagt aaaaagaacc   6360

accaacacaa aaggggttga gggggctaca atctggagac ctggggtctc ctactaactt   6420

gctatatgat ctttggtaga gttaattttc tgagtatcaa ttttcttatc tgtgaagtga   6480

agagggggat catctggcca ccaagtttaa aattctatac ttctcacctg ccaaaaccaa   6540

aaaacaactt gaggtgagga aagtgttggg cccagaaacc agggaggaac tgaaagtgac   6600

tcgcgttgaa gtggttatgt gtatgacaat gctcttggag aactgccagt cctctatggt   6660

tacccttgat ttgggagagg cagcagagtc atgtccaggg catcagacca gtgacatctt   6720

tgcctttatg cctctagtca tctgagggcg gggactaggc ctcaagcccc atctcacagc   6780

caaccacaga gcccttaagg gtggttgaca attgaatgcc ccaggttggt gctttagtta   6840

tttactccct ttgtgagcta caggatgtgt aacttttccc ccatcttggt gataaaatag   6900

gagagcgcag acacagccca cattttgtct cctttcctca gatttcatct gaaccccgct   6960

aaaggcagct gtttcacagt ctgtctcctt caggggccca atttccccac agcctgggct   7020

gagtactcct actctcttct ttaggttctg ggctgataaa gcctggagag ggtacagggt   7080

gatgggtgaa gccctggtga aggtgaaagg atagattggg gttggggggt ggggagcagg   7140

gaggtgggat ggggaatggc cttccctgaa tagggtgggt gggaggggaa caagaccctt   7200

ttgcacaact ctctttaagt ttcctttatt tcttttttaa ctcattctga ttttctgcat   7260

tgtgtttggg aaataaaatg aaaaaactaa gaccaataga aactggtttt caaaaaggca   7320

aatacactcc catctgtttc agatgctgct gagcatttca gcagtgacag attcaaataa   7380

taagctaatt tttggagaaa ggattaaaag aaaaaaaaac tttgtaatat ttatcacttg   7440

caagctatgt ttaataaaga aaggaatggt ttctaaaaaa                         7480


<210>  19
<211>  593
<212>  PRT
<213>  Homo sapiens

<400>  19


Met Asp Arg Met Thr Glu Asp Ala Leu Arg Leu Asn Leu Leu Lys Arg 
1               5                   10                  15      


Ser Leu Asp Pro Ala Asp Glu Arg Asp Asp Val Leu Ala Lys Arg Leu 
            20                  25                  30          


Lys Met Glu Gly His Glu Ala Met Glu Arg Leu Lys Met Leu Ala Leu 
        35                  40                  45              


Leu Lys Arg Lys Asp Leu Ala Asn Leu Glu Val Pro His Glu Leu Pro 
    50                  55                  60                  


Thr Lys Gln Asp Gly Ser Gly Val Lys Gly Tyr Glu Glu Lys Leu Asn 
65                  70                  75                  80  


Gly Asn Leu Arg Pro His Gly Asp Asn Arg Thr Ala Gly Arg Pro Gly 
                85                  90                  95      


Lys Glu Asn Ile Asn Asp Glu Pro Val Asp Met Ser Ala Arg Arg Ser 
            100                 105                 110         


Glu Pro Glu Arg Gly Arg Leu Thr Pro Ser Pro Asp Ile Ile Val Leu 
        115                 120                 125             


Ser Asp Asn Glu Ala Ser Ser Pro Arg Ser Ser Ser Arg Met Glu Glu 
    130                 135                 140                 


Arg Leu Lys Ala Ala Asn Leu Glu Met Phe Lys Gly Lys Gly Ile Glu 
145                 150                 155                 160 


Glu Arg Gln Gln Leu Ile Lys Gln Leu Arg Asp Glu Leu Arg Leu Glu 
                165                 170                 175     


Glu Ala Arg Leu Val Leu Leu Lys Lys Leu Arg Gln Ser Gln Leu Gln 
            180                 185                 190         


Lys Glu Asn Val Val Gln Lys Thr Pro Val Val Gln Asn Ala Ala Ser 
        195                 200                 205             


Ile Val Gln Pro Ser Pro Ala His Val Gly Gln Gln Gly Leu Ser Lys 
    210                 215                 220                 


Leu Pro Ser Arg Pro Gly Ala Gln Gly Val Glu Pro Gln Asn Leu Arg 
225                 230                 235                 240 


Thr Leu Gln Gly His Ser Val Ile Arg Ser Ala Thr Asn Thr Thr Leu 
                245                 250                 255     


Pro His Met Leu Met Ser Gln Arg Val Ile Ala Pro Asn Pro Ala Gln 
            260                 265                 270         


Leu Gln Gly Gln Arg Gly Pro Pro Lys Pro Gly Leu Val Arg Thr Thr 
        275                 280                 285             


Thr Pro Asn Met Asn Pro Ala Ile Asn Tyr Gln Pro Gln Ser Ser Ser 
    290                 295                 300                 


Ser Val Pro Cys Gln Arg Thr Thr Ser Ser Ala Ile Tyr Met Asn Leu 
305                 310                 315                 320 


Ala Ser His Ile Gln Pro Gly Thr Val Asn Arg Val Ser Ser Pro Leu 
                325                 330                 335     


Pro Ser Pro Ser Ala Met Thr Asp Ala Ala Asn Ser Gln Ala Ala Ala 
            340                 345                 350         


Lys Leu Ala Leu Arg Lys Gln Leu Glu Lys Thr Leu Leu Glu Ile Pro 
        355                 360                 365             


Pro Pro Lys Pro Pro Ala Pro Leu Leu His Phe Leu Pro Ser Ala Ala 
    370                 375                 380                 


Asn Ser Glu Phe Ile Tyr Met Val Gly Leu Glu Glu Val Val Gln Ser 
385                 390                 395                 400 


Val Ile Asp Ser Gln Gly Lys Ser Cys Ala Ser Leu Leu Arg Val Glu 
                405                 410                 415     


Pro Phe Val Cys Ala Gln Cys Arg Thr Asp Phe Thr Pro His Trp Lys 
            420                 425                 430         


Gln Glu Lys Asn Gly Lys Ile Leu Cys Glu Gln Cys Met Thr Ser Asn 
        435                 440                 445             


Gln Lys Lys Ala Leu Lys Ala Glu His Thr Asn Arg Leu Lys Asn Ala 
    450                 455                 460                 


Phe Val Lys Ala Leu Gln Gln Glu Gln Glu Ile Glu Gln Arg Leu Gln 
465                 470                 475                 480 


Gln Gln Ala Ala Leu Ser Pro Thr Thr Ala Pro Ala Val Ser Ser Val 
                485                 490                 495     


Ser Lys Gln Glu Thr Ile Met Arg His His Thr Leu Arg Gln Ala Pro 
            500                 505                 510         


Gln Pro Gln Ser Ser Leu Gln Arg Gly Ile Pro Thr Ser Ala Arg Ser 
        515                 520                 525             


Met Leu Ser Asn Phe Ala Gln Ala Pro Gln Leu Ser Val Pro Gly Gly 
    530                 535                 540                 


Leu Leu Gly Met Pro Gly Val Asn Ile Ala Tyr Leu Asn Thr Gly Ile 
545                 550                 555                 560 


Gly Gly His Lys Gly Pro Ser Leu Ala Asp Arg Gln Arg Glu Tyr Leu 
                565                 570                 575     


Leu Asp Met Ile Pro Pro Arg Ser Ile Ser Gln Ser Ile Ser Gly Gln 
            580                 585                 590         


Lys 
    

<210>  20
<211>  5688
<212>  DNA
<213>  Homo sapiens

<400>  20
ggtgggggta gcggcggcgc ccgcggcccg gagcgggggt tgggggagta gagaaagcgg     60

ggcgcgcgga ggaacgctgg gtccccggcg ccgcgggagc tgggaggacc gagccggccg    120

agcgagcagc gcggcagcac agtccccgcg tggcgcagcg cggcggggac gcggggaccg    180

cccggatctc cttccactgc gccccgcgct ctgcggtcct cggccgcctc ttcttccttc    240

actcactgcc cgggcgggag cggcgcccaa gtcgggtgcg ccatgtctgg ggccgggtag    300

ccccgccgcc cgccggcccg ccagctcgcc ctccgagcca cccgccagcg ggccggccgg    360

ccgggaagcg cgggacagat gcagtgagtg aggggggggc catggcggag gagcggcccc    420

cccggctggt ggattacttc gtggtagctg ggcttgcagg gaacggagca cccatccctg    480

aggaaacgtg ggttcctgaa cccagtgggc ccctgcgccc tccccggcca gctgagccca    540

tcacagatgt ggcagtcatc gctagggcac tgggcgagga agtgccccag ggctacacat    600

gcatccaggc ttctgctggg ggccacccct tggaactcag tgctggactt ctgggtggaa    660

ctcaacccgt catctgctac cgcaggggcc gtgacaagcc ccccctcgtt gagctggggg    720

tgttgtatga ggggaaggaa cgtcccaagc ctggcttcca agtgcttgac acgacaccct    780

acagccactc agcaaacctg gcccctccag gccccgggca cccccgcacc tacctcactt    840

accggcgggc agcagagggg gcagggctgc atgccctggg catcactgac ctctgcctgg    900

tgctgcccag taagggcgag ggcactcctc atacttactg ccggctgccc cgcaacctca    960

accctggcat gtggggccca gcagtgtacc tgtgctataa ggtgggcctg gcgaaggcca   1020

acacgctggt gtacgaggca gagctgctgg gccgctaccc ggaggaggac aatgaggcgt   1080

tcccgctgcc cgagtcagtg cccgtcttct gcctgcccat gggggccact atcgagtgct   1140

ggcctgccca gaccaagtac cccgtgcccg tcttctccac ctttgtgctc acgggtgcag   1200

ctggtgataa ggtgtatggt gccgccctgc agttctacga ggcgttccca agggccaggc   1260

tatcagagcg acaggcacgg gcactgggcc tgctgagcgc cgtggagcgg ggtcgggcac   1320

tggggggcag agctgtgcgc agccggcgtg ccatcgctgt gctgtcccgc tggcctgcct   1380

tccctgcctt ccgcgccttc ctcaccttcc tttaccgcta ctccgtctca ggcccccacc   1440

gcctaccctt ggaagcgcac atctcccact tcattcacaa cgttcccttc ccttccccac   1500

agagaccccg catcctagtg cagatgtctc cctatgacaa cttgctcctc tgtcagcctg   1560

tatcctcacc cctgcccctc agtggtgcca gcttcctgca gctgctgcag agcctgggcc   1620

ctgagctggc tatcacactg ctgctggctg tgctcacaga gcacaagctg ctagtccact   1680

cgctgcggcc agacctgctc accagcgtct gtgaggccct cgtctcgatg atcttcccac   1740

tgcactggca gtgcccctac attcctctgt gcccgctggt gctggcagat gtgctgagtg   1800

ccccagtgcc cttcattgtg ggtatccact ccagctactt tgatctgcat gacccgcctg   1860

ctgatgtcat ctgtgtagac cttgatacca acacgctctt ccagactgag gaaaagaagc   1920

tcctctcccc tcggaccctg ccccgcagac cctacaaggt tctgctggcc acactgacaa   1980

acctgtacca gcagctggac cagacataca ctggacctga ggaggaagca tccctggagt   2040

tcctactgac agactacgag gcagtgtgtg gccgcagggc ccggctggag cgcgaagtcc   2100

aaggagcctt cctccgcttc atggcctgtc tgctcaaggg ctaccgggtc ttcctgcgcc   2160

cactcaccca ggccccctcc gagggagctc gtgatgttga caaccttttc ttcctgcagg   2220

gcttcctcaa atcccgggaa cgctccagcc acaaacttta ctctcagctg ctgcacacac   2280

agatgttctc acagttcatt gaggagtgct cttttggctc tgctcgccat gctgcccttg   2340

aattctttga ctcttgtgtt gaaaaggtcc acccagagca ggagaagcct gagccgacac   2400

ccttagtgga gctagaggag ctgtcaggaa gtgagctcac tgtctttatc acacctcccg   2460

aggagcctgc cttaccagag ggcagtgaat ccactcccca gtactgctat gatggattcc   2520

cagagctacg ggctgagttg tttgagtctc ttcaagagca acctggggcc ctgcctgtgc   2580

caggcccttc ccgtagcgcc cccagcagtc ctgctcctcg ccgtaccaaa caggagatga   2640

aagttgcaca gcggatggca cagaagtcag cagctgtgcc tgagctgtgg gcccggtgcc   2700

tgctggggca ctgctatggg ctgtggttcc tgtgtctgcc tgcctatgtg cggtcggcac   2760

cctcccgagt gcaggcactg cacacagcct accatgtgct gcgccagatg gagagcggca   2820

aggtggtgct ccctgatgag gtgtgttacc gggtactgat gcagctctgc tcacactatg   2880

ggcagcctgt gctgtctgtg cgggtcatgc tggagatgcg tcaggcaggc attgtgccca   2940

acaccatcac ctatggctac tacaataagg ctgtgttgga aagcaagtgg ccgtctggca   3000

caccaggtgg gcgtctgcgc tgggccaagc tccggaatgt tgtcctgggg gctgctcagt   3060

tccgccagcc cttgagagaa cggcaacagc agcagcagca gcaacagcag cagcagcagc   3120

agcagcagca ggagcaggtg tcagcacatc aagaggcagg cagctcccag gcagagccct   3180

atttggagcg cccttcccct actcgccctc ttcagcgcca gactacttgg gctgggcgaa   3240

gtctgagaga cccagcctca ccccctggac gcctggtgaa gagtggtagc ctgggcagtg   3300

cccgaggggc acagcccact gtggaggccg gtgtggccca catgatagag gccttggggg   3360

tcctggaacc ccggggatca cctgtgccct ggcacgatgg aagtctctca gacctgagcc   3420

tgacagggga ggagccgctc cctggaggca gcccaggggg ctcaggctca gccctgagtg   3480

cccagtccac tgaggccctg gaagggctaa gtgggcgggg acccaaggct ggtgggcgac   3540

aggatgaggc aggcaccccc cgacgagggc tgggtgcccg cctccaacag ctgctcactc   3600

cttcccgcca ctcccctgcc tcccgcattc ccccacctga gctgcctcct gacctgccac   3660

ccccagcccg ccgcagcccc atggacagtc ttctgcaccc ccgggagcgc cctggatcca   3720

ctgcctccga gagctcagcc tctctgggca gtgagtggga cctctcagaa tcttctctca   3780

gcaacctgag tcttcgccgt tcctcagagc gcctcagtga cacccctgga tccttccagt   3840

caccttccct ggaaattctg ctgtccagct gctccctgtg ccgtgcctgt gattcgctgg   3900

tgtatgatga ggaaatcatg gctggctggg cacctgatga ctctaacctc aacacaacct   3960

gccccttctg cgcctgcccc tttgtgcccc tgctcagtgt ccagaccctt gattcccggc   4020

ccagtgtccc cagccccaaa tctgctggtg ccagtggcag caaagatgct cctgtccctg   4080

gtggtcctgg ccctgtgctc agtgaccgaa ggctctgcct tgctctggat gagccccagc   4140

tctgcaacgg gcacatgggg ggagcctccc ggcgggttga gagtggggca tgggcatacc   4200

tgagccccct ggtgctgcgt aaggagctgg agtcgctggt agagaacgag ggcagtgagg   4260

tgctggcgtt gcctgaactg ccctctgccc accccatcat cttctggaac cttttgtggt   4320

atttccaacg gctacgcctg cccagtattc taccaggcct ggtgctggcc tcctgtgatg   4380

ggccttcgca ctcccaggcc ccatctcctt ggctaacccc tgatccagcc tctgttcagg   4440

tacggctgct gtgggatgta ctgacccctg accccaatag ctgcccacct ctctatgtgc   4500

tctggagggt ccacagccag atcccccagc gggtggtatg gccaggccct gtacctgcat   4560

cccttagttt ggcactgttg gagtcagtgc tgcgccatgt tggactcaat gaagtgcaca   4620

aggctgtggg gctcctgctg gaaactctag ggcccccacc cactggcctg cacctgcaga   4680

ggggaatcta ccgtgagata ttattcctga caatggctgc tctgggcaag gaccacgtgg   4740

acatagtggc cttcgataag aagtacaagt ctgcctttaa caagctggcc agcagcatgg   4800

gcaaggagga gctgaggcac cggcgggcgc agatgcccac tcccaaggcc attgactgcc   4860

gaaaatgttt tggagcacct ccagaatgct agagacctta agcttccctc tccagcctag   4920

ggtggggaag tgaggaagaa gggattctag agttaaactg cttccctgtt gccttcatgg   4980

agttgggaac aggctgggaa ggatgcccag tcaaaggctc caagcgagga caacaggaag   5040

agggatccac tgttaccaaa agtcctgatt cccccatcac caacctaccc agtttgttcg   5100

tgctgatgtt gggggagatc tggggggagt tggtacagct ctgttcttcc cttgtcctat   5160

accgggaact cccctccagg gtacccacag atctgcattg ccctggtcat tttagaagtt   5220

tttgttttaa aaaacaactg gaaagatgca gagctactga gcctttgccc tgaatgggag   5280

gtagggatgt cattctccac caataatggt ccctcttccc tgacgttgct gaaggagccc   5340

aaggctctcc atgcctttct acctaagtgt ttgtatttta ttttaaatta tttattctgg   5400

agccacagcc cccttgctta tgaggttctt atggagagtg agaaagggaa gggaaatagg   5460

gcaccatggt ccggtggttt gtagttcctt caaagtcagg cactgggagc tagaggagtc   5520

tcaagctccc cttaggaaga actggtgccc cctccagtcc taatttttct tgcctgcccc   5580

gccttgggga atgcctcacc cacccaggtc ctgacctgtg caataaggat tgttccctgc   5640

gaagttttgt tggatgtaaa tatagtaaaa gctgcttctg tctttttc                5688


<210>  21
<211>  1496
<212>  PRT
<213>  Homo sapiens

<400>  21


Met Ala Glu Glu Arg Pro Pro Arg Leu Val Asp Tyr Phe Val Val Ala 
1               5                   10                  15      


Gly Leu Ala Gly Asn Gly Ala Pro Ile Pro Glu Glu Thr Trp Val Pro 
            20                  25                  30          


Glu Pro Ser Gly Pro Leu Arg Pro Pro Arg Pro Ala Glu Pro Ile Thr 
        35                  40                  45              


Asp Val Ala Val Ile Ala Arg Ala Leu Gly Glu Glu Val Pro Gln Gly 
    50                  55                  60                  


Tyr Thr Cys Ile Gln Ala Ser Ala Gly Gly His Pro Leu Glu Leu Ser 
65                  70                  75                  80  


Ala Gly Leu Leu Gly Gly Thr Gln Pro Val Ile Cys Tyr Arg Arg Gly 
                85                  90                  95      


Arg Asp Lys Pro Pro Leu Val Glu Leu Gly Val Leu Tyr Glu Gly Lys 
            100                 105                 110         


Glu Arg Pro Lys Pro Gly Phe Gln Val Leu Asp Thr Thr Pro Tyr Ser 
        115                 120                 125             


His Ser Ala Asn Leu Ala Pro Pro Gly Pro Gly His Pro Arg Thr Tyr 
    130                 135                 140                 


Leu Thr Tyr Arg Arg Ala Ala Glu Gly Ala Gly Leu His Ala Leu Gly 
145                 150                 155                 160 


Ile Thr Asp Leu Cys Leu Val Leu Pro Ser Lys Gly Glu Gly Thr Pro 
                165                 170                 175     


His Thr Tyr Cys Arg Leu Pro Arg Asn Leu Asn Pro Gly Met Trp Gly 
            180                 185                 190         


Pro Ala Val Tyr Leu Cys Tyr Lys Val Gly Leu Ala Lys Ala Asn Thr 
        195                 200                 205             


Leu Val Tyr Glu Ala Glu Leu Leu Gly Arg Tyr Pro Glu Glu Asp Asn 
    210                 215                 220                 


Glu Ala Phe Pro Leu Pro Glu Ser Val Pro Val Phe Cys Leu Pro Met 
225                 230                 235                 240 


Gly Ala Thr Ile Glu Cys Trp Pro Ala Gln Thr Lys Tyr Pro Val Pro 
                245                 250                 255     


Val Phe Ser Thr Phe Val Leu Thr Gly Ala Ala Gly Asp Lys Val Tyr 
            260                 265                 270         


Gly Ala Ala Leu Gln Phe Tyr Glu Ala Phe Pro Arg Ala Arg Leu Ser 
        275                 280                 285             


Glu Arg Gln Ala Arg Ala Leu Gly Leu Leu Ser Ala Val Glu Arg Gly 
    290                 295                 300                 


Arg Ala Leu Gly Gly Arg Ala Val Arg Ser Arg Arg Ala Ile Ala Val 
305                 310                 315                 320 


Leu Ser Arg Trp Pro Ala Phe Pro Ala Phe Arg Ala Phe Leu Thr Phe 
                325                 330                 335     


Leu Tyr Arg Tyr Ser Val Ser Gly Pro His Arg Leu Pro Leu Glu Ala 
            340                 345                 350         


His Ile Ser His Phe Ile His Asn Val Pro Phe Pro Ser Pro Gln Arg 
        355                 360                 365             


Pro Arg Ile Leu Val Gln Met Ser Pro Tyr Asp Asn Leu Leu Leu Cys 
    370                 375                 380                 


Gln Pro Val Ser Ser Pro Leu Pro Leu Ser Gly Ala Ser Phe Leu Gln 
385                 390                 395                 400 


Leu Leu Gln Ser Leu Gly Pro Glu Leu Ala Ile Thr Leu Leu Leu Ala 
                405                 410                 415     


Val Leu Thr Glu His Lys Leu Leu Val His Ser Leu Arg Pro Asp Leu 
            420                 425                 430         


Leu Thr Ser Val Cys Glu Ala Leu Val Ser Met Ile Phe Pro Leu His 
        435                 440                 445             


Trp Gln Cys Pro Tyr Ile Pro Leu Cys Pro Leu Val Leu Ala Asp Val 
    450                 455                 460                 


Leu Ser Ala Pro Val Pro Phe Ile Val Gly Ile His Ser Ser Tyr Phe 
465                 470                 475                 480 


Asp Leu His Asp Pro Pro Ala Asp Val Ile Cys Val Asp Leu Asp Thr 
                485                 490                 495     


Asn Thr Leu Phe Gln Thr Glu Glu Lys Lys Leu Leu Ser Pro Arg Thr 
            500                 505                 510         


Leu Pro Arg Arg Pro Tyr Lys Val Leu Leu Ala Thr Leu Thr Asn Leu 
        515                 520                 525             


Tyr Gln Gln Leu Asp Gln Thr Tyr Thr Gly Pro Glu Glu Glu Ala Ser 
    530                 535                 540                 


Leu Glu Phe Leu Leu Thr Asp Tyr Glu Ala Val Cys Gly Arg Arg Ala 
545                 550                 555                 560 


Arg Leu Glu Arg Glu Val Gln Gly Ala Phe Leu Arg Phe Met Ala Cys 
                565                 570                 575     


Leu Leu Lys Gly Tyr Arg Val Phe Leu Arg Pro Leu Thr Gln Ala Pro 
            580                 585                 590         


Ser Glu Gly Ala Arg Asp Val Asp Asn Leu Phe Phe Leu Gln Gly Phe 
        595                 600                 605             


Leu Lys Ser Arg Glu Arg Ser Ser His Lys Leu Tyr Ser Gln Leu Leu 
    610                 615                 620                 


His Thr Gln Met Phe Ser Gln Phe Ile Glu Glu Cys Ser Phe Gly Ser 
625                 630                 635                 640 


Ala Arg His Ala Ala Leu Glu Phe Phe Asp Ser Cys Val Glu Lys Val 
                645                 650                 655     


His Pro Glu Gln Glu Lys Pro Glu Pro Thr Pro Leu Val Glu Leu Glu 
            660                 665                 670         


Glu Leu Ser Gly Ser Glu Leu Thr Val Phe Ile Thr Pro Pro Glu Glu 
        675                 680                 685             


Pro Ala Leu Pro Glu Gly Ser Glu Ser Thr Pro Gln Tyr Cys Tyr Asp 
    690                 695                 700                 


Gly Phe Pro Glu Leu Arg Ala Glu Leu Phe Glu Ser Leu Gln Glu Gln 
705                 710                 715                 720 


Pro Gly Ala Leu Pro Val Pro Gly Pro Ser Arg Ser Ala Pro Ser Ser 
                725                 730                 735     


Pro Ala Pro Arg Arg Thr Lys Gln Glu Met Lys Val Ala Gln Arg Met 
            740                 745                 750         


Ala Gln Lys Ser Ala Ala Val Pro Glu Leu Trp Ala Arg Cys Leu Leu 
        755                 760                 765             


Gly His Cys Tyr Gly Leu Trp Phe Leu Cys Leu Pro Ala Tyr Val Arg 
    770                 775                 780                 


Ser Ala Pro Ser Arg Val Gln Ala Leu His Thr Ala Tyr His Val Leu 
785                 790                 795                 800 


Arg Gln Met Glu Ser Gly Lys Val Val Leu Pro Asp Glu Val Cys Tyr 
                805                 810                 815     


Arg Val Leu Met Gln Leu Cys Ser His Tyr Gly Gln Pro Val Leu Ser 
            820                 825                 830         


Val Arg Val Met Leu Glu Met Arg Gln Ala Gly Ile Val Pro Asn Thr 
        835                 840                 845             


Ile Thr Tyr Gly Tyr Tyr Asn Lys Ala Val Leu Glu Ser Lys Trp Pro 
    850                 855                 860                 


Ser Gly Thr Pro Gly Gly Arg Leu Arg Trp Ala Lys Leu Arg Asn Val 
865                 870                 875                 880 


Val Leu Gly Ala Ala Gln Phe Arg Gln Pro Leu Arg Glu Arg Gln Gln 
                885                 890                 895     


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Glu Gln 
            900                 905                 910         


Val Ser Ala His Gln Glu Ala Gly Ser Ser Gln Ala Glu Pro Tyr Leu 
        915                 920                 925             


Glu Arg Pro Ser Pro Thr Arg Pro Leu Gln Arg Gln Thr Thr Trp Ala 
    930                 935                 940                 


Gly Arg Ser Leu Arg Asp Pro Ala Ser Pro Pro Gly Arg Leu Val Lys 
945                 950                 955                 960 


Ser Gly Ser Leu Gly Ser Ala Arg Gly Ala Gln Pro Thr Val Glu Ala 
                965                 970                 975     


Gly Val Ala His Met Ile Glu Ala Leu Gly Val Leu Glu Pro Arg Gly 
            980                 985                 990         


Ser Pro Val Pro Trp His Asp Gly  Ser Leu Ser Asp Leu  Ser Leu Thr 
        995                 1000                 1005             


Gly Glu  Glu Pro Leu Pro Gly  Gly Ser Pro Gly Gly  Ser Gly Ser 
    1010                 1015                 1020             


Ala Leu  Ser Ala Gln Ser Thr  Glu Ala Leu Glu Gly  Leu Ser Gly 
    1025                 1030                 1035             


Arg Gly  Pro Lys Ala Gly Gly  Arg Gln Asp Glu Ala  Gly Thr Pro 
    1040                 1045                 1050             


Arg Arg  Gly Leu Gly Ala Arg  Leu Gln Gln Leu Leu  Thr Pro Ser 
    1055                 1060                 1065             


Arg His  Ser Pro Ala Ser Arg  Ile Pro Pro Pro Glu  Leu Pro Pro 
    1070                 1075                 1080             


Asp Leu  Pro Pro Pro Ala Arg  Arg Ser Pro Met Asp  Ser Leu Leu 
    1085                 1090                 1095             


His Pro  Arg Glu Arg Pro Gly  Ser Thr Ala Ser Glu  Ser Ser Ala 
    1100                 1105                 1110             


Ser Leu  Gly Ser Glu Trp Asp  Leu Ser Glu Ser Ser  Leu Ser Asn 
    1115                 1120                 1125             


Leu Ser  Leu Arg Arg Ser Ser  Glu Arg Leu Ser Asp  Thr Pro Gly 
    1130                 1135                 1140             


Ser Phe  Gln Ser Pro Ser Leu  Glu Ile Leu Leu Ser  Ser Cys Ser 
    1145                 1150                 1155             


Leu Cys  Arg Ala Cys Asp Ser  Leu Val Tyr Asp Glu  Glu Ile Met 
    1160                 1165                 1170             


Ala Gly  Trp Ala Pro Asp Asp  Ser Asn Leu Asn Thr  Thr Cys Pro 
    1175                 1180                 1185             


Phe Cys  Ala Cys Pro Phe Val  Pro Leu Leu Ser Val  Gln Thr Leu 
    1190                 1195                 1200             


Asp Ser  Arg Pro Ser Val Pro  Ser Pro Lys Ser Ala  Gly Ala Ser 
    1205                 1210                 1215             


Gly Ser  Lys Asp Ala Pro Val  Pro Gly Gly Pro Gly  Pro Val Leu 
    1220                 1225                 1230             


Ser Asp  Arg Arg Leu Cys Leu  Ala Leu Asp Glu Pro  Gln Leu Cys 
    1235                 1240                 1245             


Asn Gly  His Met Gly Gly Ala  Ser Arg Arg Val Glu  Ser Gly Ala 
    1250                 1255                 1260             


Trp Ala  Tyr Leu Ser Pro Leu  Val Leu Arg Lys Glu  Leu Glu Ser 
    1265                 1270                 1275             


Leu Val  Glu Asn Glu Gly Ser  Glu Val Leu Ala Leu  Pro Glu Leu 
    1280                 1285                 1290             


Pro Ser  Ala His Pro Ile Ile  Phe Trp Asn Leu Leu  Trp Tyr Phe 
    1295                 1300                 1305             


Gln Arg  Leu Arg Leu Pro Ser  Ile Leu Pro Gly Leu  Val Leu Ala 
    1310                 1315                 1320             


Ser Cys  Asp Gly Pro Ser His  Ser Gln Ala Pro Ser  Pro Trp Leu 
    1325                 1330                 1335             


Thr Pro  Asp Pro Ala Ser Val  Gln Val Arg Leu Leu  Trp Asp Val 
    1340                 1345                 1350             


Leu Thr  Pro Asp Pro Asn Ser  Cys Pro Pro Leu Tyr  Val Leu Trp 
    1355                 1360                 1365             


Arg Val  His Ser Gln Ile Pro  Gln Arg Val Val Trp  Pro Gly Pro 
    1370                 1375                 1380             


Val Pro  Ala Ser Leu Ser Leu  Ala Leu Leu Glu Ser  Val Leu Arg 
    1385                 1390                 1395             


His Val  Gly Leu Asn Glu Val  His Lys Ala Val Gly  Leu Leu Leu 
    1400                 1405                 1410             


Glu Thr  Leu Gly Pro Pro Pro  Thr Gly Leu His Leu  Gln Arg Gly 
    1415                 1420                 1425             


Ile Tyr  Arg Glu Ile Leu Phe  Leu Thr Met Ala Ala  Leu Gly Lys 
    1430                 1435                 1440             


Asp His  Val Asp Ile Val Ala  Phe Asp Lys Lys Tyr  Lys Ser Ala 
    1445                 1450                 1455             


Phe Asn  Lys Leu Ala Ser Ser  Met Gly Lys Glu Glu  Leu Arg His 
    1460                 1465                 1470             


Arg Arg  Ala Gln Met Pro Thr  Pro Lys Ala Ile Asp  Cys Arg Lys 
    1475                 1480                 1485             


Cys Phe  Gly Ala Pro Pro Glu  Cys 
    1490                 1495     

<210>  22
<211>  2598
<212>  DNA
<213>  Homo sapiens

<400>  22
gccgggccga ggccgcggcg gaggccgcgg ctggtactgg gagggtggca gggagggacg     60

gggaaggaag atggcgacgt cgggggcgaa cgggcctggt tcggccacgg cctcggcttc    120

caatccgcgc aaatttagtg agaagattgc gctgcagaag cagcgtcagg ccgaggagac    180

ggcggccttc gaggaggtga tgatggacat cggctccacc cggttacagg cccaaaaact    240

gcgactggca tacacaagga gctctcatta tggtgggtct ctgcccaatg ttaaccagat    300

tggctctggc ctggccgagt tccagagccc cctccactca cctttggatt catctcggag    360

cactcggcac catgggctgg tggaacgggt gcagcgagat cctcgaagaa tggtgtcccc    420

acttcgccga tacacccgcc acattgacag ctctccctat agtcctgcct acttatctcc    480

tcccccagag tctagctggc gaaggacgat ggcctggggc aatttccctg cagagaaggg    540

gcagttgttt cgactaccat ctgcacttaa caggacaagc tctgactctg cccttcatac    600

aagtgtgatg aaccccagtc cccaggatac ctacccaggc cccacacctc ccagcatcct    660

gcccagccga cgtgggggta ttctggatgg tgaaatggac cccaaagtac ctgctattga    720

ggagaacttg ctagatgaca agcatttgct gaagccatgg gatgctaaga agctatcctc    780

atcctcttcc cgacctcggt cctgtgaagt ccctggaatt aacatctttc catctcctga    840

ccagcctgcc aatgtgcctg tcctcccacc tgccatgaac acggggggct ccctacctga    900

cctcaccaac ctgcactttc ccccaccact gcccaccccc ctggaccctg aagagacagc    960

ctaccctagc ctgagtgggg gcaacagtac ctccaatttg acccacacca tgactcacct   1020

gggcatcagc aggggcatgg gcctgggccc aggctatgat gcaccaggac ttcattcacc   1080

tctcagccac ccatccctgc agtcctccct aagcaatccc aacctccagg cttccctgag   1140

cagtcctcag ccccagcttc agggctccca cagccacccc tctctgcctg cctcctcctt   1200

ggcccgccat gtactgccca ccacctccct gggccacccc tcactcagtg ctccggctct   1260

ttcctcctcc tcttcctcct cctccacttc atctcctgtt ttgggcgccc cctcttaccc   1320

tgcttctacc cctggggcct ccccccacca ccgccgtgtg cccctcagcc ccctgagttt   1380

gctcgcgggc ccagccgacg ccagaaggtc ccaacagcag ctgcccaaac agttttcgcc   1440

aacaatgtca cccaccttgt cttccatcac tcagggcgtc cccctggata ccagtaaact   1500

gtccactgac cagcggttac ccccataccc atacagctcc ccaagtctgg ttctgcctac   1560

ccagccccac accccaaagt ctctacagca gccagggctg ccctctcagt cttgttcagt   1620

gcagtcctca ggtgggcagc ccccaggcag gcagtctcat tatgggacac cgtacccacc   1680

tgggcccagt gggcatgggc aacagtctta ccaccggcca atgagtgact tcaacctggg   1740

gaatctggag cagttcagca tggagagccc atcagccagc ctggtgctgg atccccctgg   1800

cttttctgaa gggcctggat ttttaggggg tgaggggcca atgggtggcc cccaggatcc   1860

ccacaccttc aaccaccaga acttgaccca ctgttcccgc catggctcag ggcctaacat   1920

catcctcaca ggggactcct ctccaggttt ctctaaggag attgcagcag ccctggccgg   1980

agtgcctggc tttgaggtgt cagcagctgg attggagcta gggcttgggc tagaagatga   2040

gctgcgcatg gagccactgg gcctggaagg gctaaacatg ctgagtgacc cctgtgccct   2100

gctgcctgat cctgctgtgg aggagtcatt ccgcagtgac cggctccaat gagggcacct   2160

catcaccatc cctcttcttg gccccatccc ccaccaccat tcctttcctc ccttccccct   2220

ggcaggtaga gactctactc tctgtcccca gatcctcttt ctagcatgaa tgaaggatgc   2280

caagaatgag aaaaagcaag gggtttgtcc aggtggcccc tgaattctgc gcaagggatg   2340

ggcctggggg aactcaaggg agggcctaaa gcacttgtaa ctttgaaccg tctgtctgga   2400

ggtcagagcc tgttggaaag caggggtaga ggggagccct ggaagcaggg cttttccgga   2460

tgcctagggg tgggcagtgc cagcccctcc tcaccactct tccccttgca gtggaggaga   2520

gagccagagt ggatactatt ttttattaaa tatattatta tatgttaata aaaaaatcat   2580

atcaaaaaaa aaaaaaaa                                                 2598


<210>  23
<211>  693
<212>  PRT
<213>  Homo sapiens

<400>  23


Met Ala Thr Ser Gly Ala Asn Gly Pro Gly Ser Ala Thr Ala Ser Ala 
1               5                   10                  15      


Ser Asn Pro Arg Lys Phe Ser Glu Lys Ile Ala Leu Gln Lys Gln Arg 
            20                  25                  30          


Gln Ala Glu Glu Thr Ala Ala Phe Glu Glu Val Met Met Asp Ile Gly 
        35                  40                  45              


Ser Thr Arg Leu Gln Ala Gln Lys Leu Arg Leu Ala Tyr Thr Arg Ser 
    50                  55                  60                  


Ser His Tyr Gly Gly Ser Leu Pro Asn Val Asn Gln Ile Gly Ser Gly 
65                  70                  75                  80  


Leu Ala Glu Phe Gln Ser Pro Leu His Ser Pro Leu Asp Ser Ser Arg 
                85                  90                  95      


Ser Thr Arg His His Gly Leu Val Glu Arg Val Gln Arg Asp Pro Arg 
            100                 105                 110         


Arg Met Val Ser Pro Leu Arg Arg Tyr Thr Arg His Ile Asp Ser Ser 
        115                 120                 125             


Pro Tyr Ser Pro Ala Tyr Leu Ser Pro Pro Pro Glu Ser Ser Trp Arg 
    130                 135                 140                 


Arg Thr Met Ala Trp Gly Asn Phe Pro Ala Glu Lys Gly Gln Leu Phe 
145                 150                 155                 160 


Arg Leu Pro Ser Ala Leu Asn Arg Thr Ser Ser Asp Ser Ala Leu His 
                165                 170                 175     


Thr Ser Val Met Asn Pro Ser Pro Gln Asp Thr Tyr Pro Gly Pro Thr 
            180                 185                 190         


Pro Pro Ser Ile Leu Pro Ser Arg Arg Gly Gly Ile Leu Asp Gly Glu 
        195                 200                 205             


Met Asp Pro Lys Val Pro Ala Ile Glu Glu Asn Leu Leu Asp Asp Lys 
    210                 215                 220                 


His Leu Leu Lys Pro Trp Asp Ala Lys Lys Leu Ser Ser Ser Ser Ser 
225                 230                 235                 240 


Arg Pro Arg Ser Cys Glu Val Pro Gly Ile Asn Ile Phe Pro Ser Pro 
                245                 250                 255     


Asp Gln Pro Ala Asn Val Pro Val Leu Pro Pro Ala Met Asn Thr Gly 
            260                 265                 270         


Gly Ser Leu Pro Asp Leu Thr Asn Leu His Phe Pro Pro Pro Leu Pro 
        275                 280                 285             


Thr Pro Leu Asp Pro Glu Glu Thr Ala Tyr Pro Ser Leu Ser Gly Gly 
    290                 295                 300                 


Asn Ser Thr Ser Asn Leu Thr His Thr Met Thr His Leu Gly Ile Ser 
305                 310                 315                 320 


Arg Gly Met Gly Leu Gly Pro Gly Tyr Asp Ala Pro Gly Leu His Ser 
                325                 330                 335     


Pro Leu Ser His Pro Ser Leu Gln Ser Ser Leu Ser Asn Pro Asn Leu 
            340                 345                 350         


Gln Ala Ser Leu Ser Ser Pro Gln Pro Gln Leu Gln Gly Ser His Ser 
        355                 360                 365             


His Pro Ser Leu Pro Ala Ser Ser Leu Ala Arg His Val Leu Pro Thr 
    370                 375                 380                 


Thr Ser Leu Gly His Pro Ser Leu Ser Ala Pro Ala Leu Ser Ser Ser 
385                 390                 395                 400 


Ser Ser Ser Ser Ser Thr Ser Ser Pro Val Leu Gly Ala Pro Ser Tyr 
                405                 410                 415     


Pro Ala Ser Thr Pro Gly Ala Ser Pro His His Arg Arg Val Pro Leu 
            420                 425                 430         


Ser Pro Leu Ser Leu Leu Ala Gly Pro Ala Asp Ala Arg Arg Ser Gln 
        435                 440                 445             


Gln Gln Leu Pro Lys Gln Phe Ser Pro Thr Met Ser Pro Thr Leu Ser 
    450                 455                 460                 


Ser Ile Thr Gln Gly Val Pro Leu Asp Thr Ser Lys Leu Ser Thr Asp 
465                 470                 475                 480 


Gln Arg Leu Pro Pro Tyr Pro Tyr Ser Ser Pro Ser Leu Val Leu Pro 
                485                 490                 495     


Thr Gln Pro His Thr Pro Lys Ser Leu Gln Gln Pro Gly Leu Pro Ser 
            500                 505                 510         


Gln Ser Cys Ser Val Gln Ser Ser Gly Gly Gln Pro Pro Gly Arg Gln 
        515                 520                 525             


Ser His Tyr Gly Thr Pro Tyr Pro Pro Gly Pro Ser Gly His Gly Gln 
    530                 535                 540                 


Gln Ser Tyr His Arg Pro Met Ser Asp Phe Asn Leu Gly Asn Leu Glu 
545                 550                 555                 560 


Gln Phe Ser Met Glu Ser Pro Ser Ala Ser Leu Val Leu Asp Pro Pro 
                565                 570                 575     


Gly Phe Ser Glu Gly Pro Gly Phe Leu Gly Gly Glu Gly Pro Met Gly 
            580                 585                 590         


Gly Pro Gln Asp Pro His Thr Phe Asn His Gln Asn Leu Thr His Cys 
        595                 600                 605             


Ser Arg His Gly Ser Gly Pro Asn Ile Ile Leu Thr Gly Asp Ser Ser 
    610                 615                 620                 


Pro Gly Phe Ser Lys Glu Ile Ala Ala Ala Leu Ala Gly Val Pro Gly 
625                 630                 635                 640 


Phe Glu Val Ser Ala Ala Gly Leu Glu Leu Gly Leu Gly Leu Glu Asp 
                645                 650                 655     


Glu Leu Arg Met Glu Pro Leu Gly Leu Glu Gly Leu Asn Met Leu Ser 
            660                 665                 670         


Asp Pro Cys Ala Leu Leu Pro Asp Pro Ala Val Glu Glu Ser Phe Arg 
        675                 680                 685             


Ser Asp Arg Leu Gln 
    690             

<210>  24
<211>  2445
<212>  DNA
<213>  Homo sapiens

<400>  24
aggagagtca ggccaatggg gccgcagttc tttctttttt ttttctttat tcttattttt     60

ggagacaggg tctcgctctg ttgcccaggc tggagtgcgg tggtgcgatc acggttccat    120

gcagcccccg acctcccggg ctcaggtgat tctcccgcct cagcaccgcg agcagctagg    180

accacaggcg cgagccactg cgtccggccg gcgggactta tttgtcaggc ggggattggg    240

ttccgccagc ctaaagggag gggtaagcgc cagaatatga atcgccggga agctgggaga    300

aagctccggg aaaccctgag cagccaggtc gcctgctccg cccgctcccg ctcccgatct    360

ctgattgctc ctaactgacg tcactcccgg tctgtccccg cccactcggt gctgccattg    420

gcagtcggtc gtgggtctga gagtcactgg agctaccaga agcatcatgg ggccctgggg    480

agagccagag ctcctggtgt ggcgccccga ggcggtagct tcagagcctc cagtgcctgt    540

ggggctggag gtgaagttgg gggccctggt gctgctgctg gtgctcaccc tcctctgcag    600

cctggtgccc atctgtgtgc tgcgccggcc aggagctaac catgaaggct cagcttcccg    660

ccagaaagcc ctgagcctag taagctgttt cgcggggggc gtctttttgg ccacttgtct    720

cctggacctg ctgcctgact acctggctgc catagatgag gccctggcag ccttgcacgt    780

gacgctccag ttcccactgc aagagttcat cctggccatg ggcttcttcc tggtcctggt    840

gatggagcag atcacactgg cttacaagga gcagtcaggg ccgtcacctc tggaggaaac    900

aagggctctg ctgggaacag tgaatggtgg gccgcagcat tggcatgatg ggccaggggt    960

cccacaggcg agtggagccc cagcaacccc ctcagccttg cgtgcctgtg tactggtgtt   1020

ctccctggcc ctccactccg tgttcgaggg gctggcggta gggctgcagc gagaccgggc   1080

tcgggccatg gagctgtgcc tggctttgct gctccacaag ggcatcctgg ctgtcagcct   1140

gtccctgcgg ctgttgcaga gccaccttag ggcacaggtg gtggctggct gtgggatcct   1200

cttctcatgc atgacacctc taggcatcgg gctgggtgca gctctggcag agtcggcagg   1260

acctctgcac cagctggccc agtctgtgct agagggcatg gcagctggca cctttctcta   1320

tatcaccttt ctggaaatcc tgccccagga gctggccagt tctgagcaaa ggatcctcaa   1380

ggtcattctg ctcctagcag gctttgccct gctcactggc ctgctcttca tccaaatcta   1440

gggggcttca agagaggggc aggggagatt gatgatcagg tgcccctgtt ctcccttccc   1500

tcccccagtt gtggggaata ggaaggaaag gggaagggaa atactgagga ccaaaaagtt   1560

ctctgggagc taaagataga gcctttgggg ctatctgact aatgagaggg aagtgggcag   1620

acaagaggct ggccccagtc ccaaggaaca agagatggtc aagtcgctag agacatatca   1680

ggggacatta ggattgggga agacacttga ctgctagaat cagaggttgg acactataca   1740

taaggacagg ctcacatggg aggctggagg tgggtaccca gctgctgtgg aacgggtatg   1800

gacaggtcat aaacctagag tcagtgtcct gttggtccta gcccatttca gcaccctgcc   1860

acttggagtg gacccctcct actcttctta gcgcctaccc tcatacctat ctccctcctc   1920

ccatctccta ggggactggc gccaaatggt ctctccctgc caattttggt atcttctctg   1980

gcctctccag tcctgcttac tcctctattt ttaaagtgcc aaacaaatcc ccttcctctt   2040

tctcaaagca cagtaatgtg gcactgagcc ctacccagca cctcagtgaa gggggcctgc   2100

ttgctcttta ttttggtccc ggatcctggg gtggggcaga aatattttct gggctggggt   2160

aggaggaagg ttgttgcagc catctactgc tgctgtaccc taggaatatg gggacatgga   2220

catggtgtcc catgcccaga tgataaacac tgagctgcca aaacattttt ttaaatacac   2280

ccgaggagcc caagggggaa gggcaatgcc tacccccagc gttatttttg gggagggagg   2340

gctgtgcata gggacatatt ctttagaatc tattttatta actgacctgt tttgggacct   2400

gttacccaaa taaaagatgt ttctagaaaa aaaaaaaaaa aaaaa                   2445


<210>  25
<211>  324
<212>  PRT
<213>  Homo sapiens

<400>  25


Met Gly Pro Trp Gly Glu Pro Glu Leu Leu Val Trp Arg Pro Glu Ala 
1               5                   10                  15      


Val Ala Ser Glu Pro Pro Val Pro Val Gly Leu Glu Val Lys Leu Gly 
            20                  25                  30          


Ala Leu Val Leu Leu Leu Val Leu Thr Leu Leu Cys Ser Leu Val Pro 
        35                  40                  45              


Ile Cys Val Leu Arg Arg Pro Gly Ala Asn His Glu Gly Ser Ala Ser 
    50                  55                  60                  


Arg Gln Lys Ala Leu Ser Leu Val Ser Cys Phe Ala Gly Gly Val Phe 
65                  70                  75                  80  


Leu Ala Thr Cys Leu Leu Asp Leu Leu Pro Asp Tyr Leu Ala Ala Ile 
                85                  90                  95      


Asp Glu Ala Leu Ala Ala Leu His Val Thr Leu Gln Phe Pro Leu Gln 
            100                 105                 110         


Glu Phe Ile Leu Ala Met Gly Phe Phe Leu Val Leu Val Met Glu Gln 
        115                 120                 125             


Ile Thr Leu Ala Tyr Lys Glu Gln Ser Gly Pro Ser Pro Leu Glu Glu 
    130                 135                 140                 


Thr Arg Ala Leu Leu Gly Thr Val Asn Gly Gly Pro Gln His Trp His 
145                 150                 155                 160 


Asp Gly Pro Gly Val Pro Gln Ala Ser Gly Ala Pro Ala Thr Pro Ser 
                165                 170                 175     


Ala Leu Arg Ala Cys Val Leu Val Phe Ser Leu Ala Leu His Ser Val 
            180                 185                 190         


Phe Glu Gly Leu Ala Val Gly Leu Gln Arg Asp Arg Ala Arg Ala Met 
        195                 200                 205             


Glu Leu Cys Leu Ala Leu Leu Leu His Lys Gly Ile Leu Ala Val Ser 
    210                 215                 220                 


Leu Ser Leu Arg Leu Leu Gln Ser His Leu Arg Ala Gln Val Val Ala 
225                 230                 235                 240 


Gly Cys Gly Ile Leu Phe Ser Cys Met Thr Pro Leu Gly Ile Gly Leu 
                245                 250                 255     


Gly Ala Ala Leu Ala Glu Ser Ala Gly Pro Leu His Gln Leu Ala Gln 
            260                 265                 270         


Ser Val Leu Glu Gly Met Ala Ala Gly Thr Phe Leu Tyr Ile Thr Phe 
        275                 280                 285             


Leu Glu Ile Leu Pro Gln Glu Leu Ala Ser Ser Glu Gln Arg Ile Leu 
    290                 295                 300                 


Lys Val Ile Leu Leu Leu Ala Gly Phe Ala Leu Leu Thr Gly Leu Leu 
305                 310                 315                 320 


Phe Ile Gln Ile 
                

<210>  26
<211>  1747
<212>  DNA
<213>  Homo sapiens

<400>  26
ccatgatctc cctcttgcaa aagcgagggc tacagaacag gcattcagga gtcctgtgct     60

ccagtcacag ccttttctgt tcttcagcta ggagacacca aaccctcagg aagatttact    120

atagctaaga gaaaactgca gcagaaaggg cgcggctacc tacttcttaa attccgtttg    180

tggaccctca gactcttagt cccctactcc cagatacagc ggccctaccg tggctcctgg    240

caaggtggca tccacttttg tagtaagcat ggatctcgga atccctgacc tgctggacgc    300

gtggctggag cccccagagg atatcttctc gacaggatcc gtcctggagc tgggactcca    360

ctgcccccct ccagaggttc cggtaactag gctacaggaa cagggactgc aaggctggaa    420

gtccggtggg gaccgtggct gtggccttca agagagtgag cctgaagatt tcttgaagct    480

tttcattgat cccaatgagg tgtactgctc agaagcatct cctggcagtg acagtggcat    540

ctctgaggac ccctgccatc cagacagtcc ccctgccccc agggcaacca gttctcctat    600

gctctatgag gttgtctatg aggcaggggc cctggagagg atgcaggggg aaactgggcc    660

aaatgtaggc cttatctcca tccagctaga tcagtggagc ccagcattta tggtgcctga    720

ttcctgcatg gtcagtgagc tgccctttga tgctcatgcc cacatcctgc ccagagcagg    780

caccgtagcc ccagtgccct gtacaaccct gctgccctgt caaaccctgt tcctgaccga    840

tgaggagaag cgtctgctgg ggcaggaagg ggtttccctg ccctctcacc tgcccctcac    900

caaggcagag gagagggtcc tcaagaaggt caggaggaaa atccgtaaca agcagtcagc    960

tcaggacagt cggcggcgga agaaggagta cattgatggg ctggagagca gggtggcagc   1020

ctgttctgca cagaaccaag aattacagaa aaaagtccag gagctggaga ggcacaacat   1080

ctccttggta gctcagctcc gccagctgca gacgctaatt gctcaaactt ccaacaaagc   1140

tgcccagacc agcacttgtg ttttgattct tcttttttcc ctggctctca tcatcctgcc   1200

cagcttcagt ccattccaga gtcgaccaga agctgggtct gaggattacc agcctcacgg   1260

agtgacttcc agaaatatcc tgacccacaa ggacgtaaca gaaaatctgg agacccaagt   1320

ggtagagtcc agactgaggg agccacctgg agccaaggat gcaaatggct caacaaggac   1380

actgcttgag aagatgggag ggaagccaag acccagtggg cgcatccggt ccgtgctgca   1440

tgcagatgag atgtgagctg gaacagacct tcctggccca cttcctgatc acaaggaatc   1500

ctgggcttcc ttatggcttt gcttcccact gggattccta cttaggtgtc tgccctcagg   1560

ggtccaaatc acttcaggac accccaagag atgtccttta gtctctgcct gaggcctagt   1620

ctgcatttgt ttgcatatat gagagggtac ctcaaatact tctgttatgt atctgtgatt   1680

ttatttcttc tttgggtata gggttgaggg gaaataagtt ttgagtgaga aataaacgtt   1740

ttagctg                                                             1747


<210>  27
<211>  395
<212>  PRT
<213>  Homo sapiens

<400>  27


Met Asp Leu Gly Ile Pro Asp Leu Leu Asp Ala Trp Leu Glu Pro Pro 
1               5                   10                  15      


Glu Asp Ile Phe Ser Thr Gly Ser Val Leu Glu Leu Gly Leu His Cys 
            20                  25                  30          


Pro Pro Pro Glu Val Pro Val Thr Arg Leu Gln Glu Gln Gly Leu Gln 
        35                  40                  45              


Gly Trp Lys Ser Gly Gly Asp Arg Gly Cys Gly Leu Gln Glu Ser Glu 
    50                  55                  60                  


Pro Glu Asp Phe Leu Lys Leu Phe Ile Asp Pro Asn Glu Val Tyr Cys 
65                  70                  75                  80  


Ser Glu Ala Ser Pro Gly Ser Asp Ser Gly Ile Ser Glu Asp Pro Cys 
                85                  90                  95      


His Pro Asp Ser Pro Pro Ala Pro Arg Ala Thr Ser Ser Pro Met Leu 
            100                 105                 110         


Tyr Glu Val Val Tyr Glu Ala Gly Ala Leu Glu Arg Met Gln Gly Glu 
        115                 120                 125             


Thr Gly Pro Asn Val Gly Leu Ile Ser Ile Gln Leu Asp Gln Trp Ser 
    130                 135                 140                 


Pro Ala Phe Met Val Pro Asp Ser Cys Met Val Ser Glu Leu Pro Phe 
145                 150                 155                 160 


Asp Ala His Ala His Ile Leu Pro Arg Ala Gly Thr Val Ala Pro Val 
                165                 170                 175     


Pro Cys Thr Thr Leu Leu Pro Cys Gln Thr Leu Phe Leu Thr Asp Glu 
            180                 185                 190         


Glu Lys Arg Leu Leu Gly Gln Glu Gly Val Ser Leu Pro Ser His Leu 
        195                 200                 205             


Pro Leu Thr Lys Ala Glu Glu Arg Val Leu Lys Lys Val Arg Arg Lys 
    210                 215                 220                 


Ile Arg Asn Lys Gln Ser Ala Gln Asp Ser Arg Arg Arg Lys Lys Glu 
225                 230                 235                 240 


Tyr Ile Asp Gly Leu Glu Ser Arg Val Ala Ala Cys Ser Ala Gln Asn 
                245                 250                 255     


Gln Glu Leu Gln Lys Lys Val Gln Glu Leu Glu Arg His Asn Ile Ser 
            260                 265                 270         


Leu Val Ala Gln Leu Arg Gln Leu Gln Thr Leu Ile Ala Gln Thr Ser 
        275                 280                 285             


Asn Lys Ala Ala Gln Thr Ser Thr Cys Val Leu Ile Leu Leu Phe Ser 
    290                 295                 300                 


Leu Ala Leu Ile Ile Leu Pro Ser Phe Ser Pro Phe Gln Ser Arg Pro 
305                 310                 315                 320 


Glu Ala Gly Ser Glu Asp Tyr Gln Pro His Gly Val Thr Ser Arg Asn 
                325                 330                 335     


Ile Leu Thr His Lys Asp Val Thr Glu Asn Leu Glu Thr Gln Val Val 
            340                 345                 350         


Glu Ser Arg Leu Arg Glu Pro Pro Gly Ala Lys Asp Ala Asn Gly Ser 
        355                 360                 365             


Thr Arg Thr Leu Leu Glu Lys Met Gly Gly Lys Pro Arg Pro Ser Gly 
    370                 375                 380                 


Arg Ile Arg Ser Val Leu His Ala Asp Glu Met 
385                 390                 395 

<210>  28
<211>  1574
<212>  DNA
<213>  Homo sapiens

<400>  28
acacagcttc tccactggat catcggtggc gatgaagggg cggctgggga aggatgtcag     60

agaaaccaga agcttgacgg tgaatcctcg ggttttaagg agagagcaaa gtcctgagag    120

ggcgacgtat tgtccctgct cacctagccc agaatgaaca aacacgcgcc agccagggag    180

cagcgagccg agaattcgga cgagcctctg caaccgccat ttgccgttct cgcaaagact    240

accaagacca caatgcaacg gggcgccgag ctaattccca gtgagcagca ggcgaggcgc    300

caccgacgcg gaagactata agccccagcg ggcgacgacc gaacgccccc gggaacaccg    360

ggccccgagc tcggtcccgc gcccgaggat cctccacggg gctagatggc tgcgtcgggg    420

gcgggagcgg aggtgagcgg gcgctagggc cgcgagcccc cgccggccct tcctccagcg    480

ccctgcggac cccgcagaag gcgctcgcct ccctagcccg caaaaacata tcgatttttc    540

tcgctgtggc aacggggacg tcctgataga tcctctgctc caataggcaa ctccggcctt    600

ccctgccctg acctggaacc tctgggaggg ctgcagagta agtgccgcct ctgcgctccg    660

acggaggcac gaggcctgtg gagtaggtcc ctctgttccg acaggtgcga cacttggcgc    720

tccatgcttg cgggtgccgg gaggcctggc ctcccccagg gccgccacct ctgctggttg    780

ctctgtgctt tcaccttaaa gctctgccaa gcagaggctc ccgtgcagga agagaagctg    840

tcagcaagca cctcaaattt gccatgctgg ctggtggaag agtttgtggt agcagaagag    900

tgctctccat gctctaattt ccgggctaaa actacccctg agtgtggtcc cacaggatat    960

gtagagaaaa tcacatgcag ctcatctaag agaaatgagt tcaaaagctg ccgctcagct   1020

ttgatggaac aacgcttatt ttggaagttc gaaggggctg tcgtgtgtgt ggccctgatc   1080

ttcgcttgtc ttgtcatcat tcgtcagcga caattggaca gaaaggctct ggaaaaggtc   1140

cggaagcaaa tcgagtccat atagctacat tccacccttg tatcctgggt cttagagacc   1200

ctatctcaga cagtgaaagt gaaatggact gatttgcact cttggttctt tggagccttg   1260

tggtggaatc cccttttccc catcttcttc tttcagatca ttaatgagca gaataaaaag   1320

agtaaaatgg tttccttccc ttctgtaact tggagcagga agtcatgggg gcagagaggg   1380

aaaggaggtg gttacttaag gccccaatct accaagtctt ccccaccact tctcccttgt   1440

tttccccctc ttctactact tatttcaaac ttctgggata caatttcagc taaaacgttt   1500

atttctcact caaaacttat ttcccctcaa ccctataccc aaagaagaaa taaaatcaca   1560

gatacataac agaa                                                     1574


<210>  29
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  29


Met Leu Ala Gly Ala Gly Arg Pro Gly Leu Pro Gln Gly Arg His Leu 
1               5                   10                  15      


Cys Trp Leu Leu Cys Ala Phe Thr Leu Lys Leu Cys Gln Ala Glu Ala 
            20                  25                  30          


Pro Val Gln Glu Glu Lys Leu Ser Ala Ser Thr Ser Asn Leu Pro Cys 
        35                  40                  45              


Trp Leu Val Glu Glu Phe Val Val Ala Glu Glu Cys Ser Pro Cys Ser 
    50                  55                  60                  


Asn Phe Arg Ala Lys Thr Thr Pro Glu Cys Gly Pro Thr Gly Tyr Val 
65                  70                  75                  80  


Glu Lys Ile Thr Cys Ser Ser Ser Lys Arg Asn Glu Phe Lys Ser Cys 
                85                  90                  95      


Arg Ser Ala Leu Met Glu Gln Arg Leu Phe Trp Lys Phe Glu Gly Ala 
            100                 105                 110         


Val Val Cys Val Ala Leu Ile Phe Ala Cys Leu Val Ile Ile Arg Gln 
        115                 120                 125             


Arg Gln Leu Asp Arg Lys Ala Leu Glu Lys Val Arg Lys Gln Ile Glu 
    130                 135                 140                 


Ser Ile 
145     

<210>  30
<211>  1211
<212>  DNA
<213>  Homo sapiens

<400>  30
ctgggctccg tgccgctctg tttgccaacc gtccagtccc gcctaccagt gccgggcgct     60

ccccacccct cccccggctc ccccggtgtc cgccatggcc aaagcctacg accacctctt    120

caagttgctg ctgatcgggg actcgggggt gggcaagact tgtctgatca ttcgctttgc    180

agaggacaac ttcaacaaca cttacatctc caccatcgga attgatttca agatccgcac    240

tgtggatata gaggggaaga agatcaaact acaagtctgg gacacggctg gccaagagcg    300

gttcaagaca ataactactg cctactaccg tggagccatg ggcattatcc tagtatacga    360

catcacggat gagaaatctt tcgagaatat tcagaactgg atgaaaagca tcaaggagaa    420

tgcctcggct ggggtggagc gcctcttgct ggggaacaaa tgtgacatgg aggccaagag    480

gaaggtgcag aaggagcagg ccgataagtt ggctcgagag catggaatcc gatttttcga    540

aactagtgct aaatccagta tgaatgtgga tgaggctttt agttccctgg cccgggacat    600

cttgctcaag tcaggaggcc ggagatcagg aaacggcaac aagcctccca gtactgacct    660

gaaaacttgt gacaagaaga acaccaacaa gtgctccctg ggctgaggac cctttcttgc    720

ctccccaccc cggaagctga acctgaggga gacaacggca gagggagtga gcaggggaga    780

aatagcagag gggcttggag ggtcacatag gtagatggta aagagaatga ggagaaaaag    840

gagaaaaggg aaaagcagaa aggaaaaaaa ggaagagaga ggaagggaga agggagagga    900

atgaattgag gaagtgaaag aaggcaagga ggtaggaaga gagggaggag gaaaggaagg    960

agagatgcct caggcttcag accttacctg ggttttcagg gcaaacataa atgtaaatac   1020

actgatttat tctgttacta gatcaggttt tagggtcctg caaaaggcta gctcggcact   1080

acactaggga atttgctcct gttctgtcac ttgtcatggt ctttcttggt attaaaggcc   1140

accatttgca caaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   1200

aaaaaaaaaa a                                                        1211


<210>  31
<211>  203
<212>  PRT
<213>  Homo sapiens

<400>  31


Met Ala Lys Ala Tyr Asp His Leu Phe Lys Leu Leu Leu Ile Gly Asp 
1               5                   10                  15      


Ser Gly Val Gly Lys Thr Cys Leu Ile Ile Arg Phe Ala Glu Asp Asn 
            20                  25                  30          


Phe Asn Asn Thr Tyr Ile Ser Thr Ile Gly Ile Asp Phe Lys Ile Arg 
        35                  40                  45              


Thr Val Asp Ile Glu Gly Lys Lys Ile Lys Leu Gln Val Trp Asp Thr 
    50                  55                  60                  


Ala Gly Gln Glu Arg Phe Lys Thr Ile Thr Thr Ala Tyr Tyr Arg Gly 
65                  70                  75                  80  


Ala Met Gly Ile Ile Leu Val Tyr Asp Ile Thr Asp Glu Lys Ser Phe 
                85                  90                  95      


Glu Asn Ile Gln Asn Trp Met Lys Ser Ile Lys Glu Asn Ala Ser Ala 
            100                 105                 110         


Gly Val Glu Arg Leu Leu Leu Gly Asn Lys Cys Asp Met Glu Ala Lys 
        115                 120                 125             


Arg Lys Val Gln Lys Glu Gln Ala Asp Lys Leu Ala Arg Glu His Gly 
    130                 135                 140                 


Ile Arg Phe Phe Glu Thr Ser Ala Lys Ser Ser Met Asn Val Asp Glu 
145                 150                 155                 160 


Ala Phe Ser Ser Leu Ala Arg Asp Ile Leu Leu Lys Ser Gly Gly Arg 
                165                 170                 175     


Arg Ser Gly Asn Gly Asn Lys Pro Pro Ser Thr Asp Leu Lys Thr Cys 
            180                 185                 190         


Asp Lys Lys Asn Thr Asn Lys Cys Ser Leu Gly 
        195                 200             

<210>  32
<211>  5913
<212>  DNA
<213>  Homo sapiens

<400>  32
acgcctgtgg attggctgat ggagctgtga gccggctgta gttgagcggg aacccgagac     60

ctggcagtcg ccatgactgg ctgtccggcg tcatcaagac gccgaggctt cgggctcttt    120

ttcttcttgc gtctacaccg cctcctgttg ttgtttctgg ttttgcgtgg gaccctggcc    180

aacaaactta acgtgccaca ggtgttgcta cccttcggcc gagagccagg ccgggtgcct    240

ttcctgctgg aggcccagcg gggctgctac acttggcatt ccacccatca tgatgcagtt    300

actgttgagc ctttatatga aaatggcacc ttgtgttccc aaaaagctgt actcattgct    360

gaatctacgc aaccgatacg cctcagcagt attattcttg ctcgagaaat agtgactgac    420

catgagctac gctgtgatgt taaggttgat gtgataaaca gcattgaaat tgtatctcgg    480

gcccgggaac tttatgtaga tgattcgcca ctggaactga tggtgagggc attggatgct    540

gaaggaaata cttttagtag tttggcaggg atgatgtttg agtggagcat tgcccaggac    600

aacgagtcag caagagaaga actgtctagc aaaattagga ttcttaaata ctccgaagca    660

gaatatgctc ccccaatata tatagctgag atggaaaaag aggagaaaca aggagatgtg    720

attttagtgt ctgggattag aactggtgct gctgttgtaa aagttcgaat tcatgaacca    780

ttctataaga aagtggcagc agccttaata cgtctgcttg ttttggagaa tatatttctt    840

ataccatccc atgatattta tctcttagta ggaacatata ttaaatacca agttgcaaaa    900

atggttcaag ggagagtgac agaggtgaaa tttcccctgg aacattatat actggaattg    960

caagaccata gagttgcact taacgggtct cattctgaga aagtggctat actggatgac   1020

aaaacagcca tggtgactgc ctcacaactg ggccagacta atcttgtctt tgtccataaa   1080

aatgttcata tgcgatctgt gtctggactc ccaaattgca ccatatatgt tgtagagcct   1140

ggatttttag gtttcactgt ccaacctgga aaccgatgga gtctagaggt gggacaggta   1200

tatgtcatta cagtagacgt ctttgataaa agcagcacaa aggtctatat ttcagataat   1260

ctcaggatta catacgactt tcctaaggag tactttgaag agcaactaac taccgtgaat   1320

ggatcttacc atatagtaaa agccctgaaa gatggtgttg tggtaataaa tgcatccctg   1380

acctccatca tttaccagaa taaagatatt cagcctataa aatttctaat caaacaccaa   1440

caagaagtga agatttattt tcccatcatg cttacaccca aatttctggc atttcctcat   1500

catcctatgg gaatgttata tcgttataaa gtacaggtag agggtggcag tggcaacttt   1560

acctggactt cttctaatga aacagtggtc atagtaacca cgaaaggagt ggtgactgca   1620

ggtcaggtca gggggaatag tactgttttg gcccgagatg tacaaaatcc ctttcgatat   1680

ggagaaatta agatacatgt cctgaaactg aacaaaatgg aactgttacc atttcatgct   1740

gatgtggaga ttggccagat tatagaaata cccattgcaa tgtatcacat aaataaagag   1800

accaaagaag ccatggcatt cacagactgc tctcatttat ccttggatct gaacatggat   1860

aaacaaggag tctttactct tctcaaagaa ggtattcaaa gacctggacc aatgcattgt   1920

tccagtacac atatcgcagc taaatctctt ggccatactc tggtaacagt aagtgtgaat   1980

gaatgtgaca agtacttgga gagcagtgct acatttgctg cttatgaacc cctaaaggct   2040

ttaaatcctg tggaagtggc attggtgaca tggcagtctg tgaaggaaat ggtatttgaa   2100

gggggtcctc gtccatggat cttggagccc tcccgatttt ttttggaatt gaatgcggag   2160

aagacagaga agattggaat agcacaagtg tggctgccat ctaagagaaa acagaaccag   2220

tacatctacc ggatccaatg cctggattta ggggaacaag ttctcacatt ccgaattgga   2280

aatcatccag gtgtcctgaa ccctagtcca gctgtagagg ttttgcaggt tcgcttcatt   2340

tgtgcccacc ctgccagtat gtcagtaact ccagtataca aggtgccagc tggtgcccag   2400

ccatgtcctc tgccacagca caacaaatgg ctgattcctg tatcaagact gagggacaca   2460

gtcctggaac tagcagtgtt tgatcaacat aggagaaagt ttgataattt cagttcacta   2520

atgctagaat ggaaatcctc caatgaaaca ctagcccatt tcgaagatta taaatcagtg   2580

gaaatggtag caaaagatga tggcagtggg cagacccggt tacatggtca tcagatcctt   2640

aaagtacatc agataaaagg gactgtactg attggagtca attttgtggg ctattcagag   2700

aagaaaagcc caaaagaaat ttccaacttg cccagatctg tagatgtgga actgctcctg   2760

gtagatgatg taactgtagt gcctgagaat gccaccatct ataaccaccc tgatgtaaag   2820

gaaacattta gccttgtgga aggatctggt tattttttag tcaacagcag tgagcagggt   2880

gttgtcacca tcacttacat ggaagcagaa agctctgttg agttagttcc attacatcct   2940

ggatttttta ccttggaggt ctatgatctt tgtttggctt tcttgggtcc agcaacagcc   3000

cacctcaggg tgtcagacat acaagagctg gagcttgatc tgattgataa ggttgaaata   3060

gacaaaactg tgttagtgac tgtgagggtt cttggctctt ccaaacgccc attccaaaat   3120

aaatacttca gaaacatgga actcaaactg cagttggctt ctgccattgt caccctgaca   3180

ccaatggagc aacaggacga atactctgaa aattatattc ttcgagctac cactattggg   3240

caaaccacac ttgtggctat tgccaaggac aagatgggaa gaaaatacac atcaactcct   3300

cggcacattg aagtgtttcc tccattcaga cttcttccag agaaaatgac actgattcca   3360

atgaatatga tgcaggtaat gtctgaaggt ggcccccagc cccaatccat cgttcacttc   3420

tccatcagta atcagaccgt ggctgttgtt aataggaggg ggcaagttac agggaagatt   3480

gttggcacag ctgtggttca tggcaccatc cagacagtaa atgaagatac tggcaaagtc   3540

attgtgtttt ctcaggatga agtacagatt gaagttgttc agctaagggc tgttaggatc   3600

cttgcagctg caactcggct catcacagct accaagatgc cagtttatgt catgggagta   3660

accagtaccc agaccccttt ctccttcagc aatgctaatc ctgggctcac attccactgg   3720

tctatgagca aaagggatgt attggatcta gtgcccaggc attcagaggt ttttctacag   3780

ctcccagtag agcataactt tgccatggtt gtccatacaa aagcagcagg caggaccagt   3840

atcaaggtca ctgttcactg catgaacagt tcctctgggc agtttgaggg gaatttgttg   3900

gaactctctg atgaagtaca gatcctggtg tttgaaaaac tccaactctt ctatccagag   3960

tgccaaccag agcagattct gatgcctata aattctcagc tcaaactcca taccaacagg   4020

gaaggagctg ccttcgtgag ttctcgtgtt ctcaagtgtt tccctaattc atccgtcatt   4080

gaggaggatg gtgaagggct cctgaaagct ggttccattg caggtactgc tgtattggaa   4140

gtcacttcta tagaaccttt tggagtcaac caaacaacca taactggggt ccaggtagca   4200

ccggtgacat acctgcgagt gagcagccaa cccaagctat acacagccca aggaaggacc   4260

ctgtcagcat ttcccttggg catgtctctt accttcactg ttcagtttta taatagtatc   4320

ggagagaaat tccacacaca caatacccag ctttatctgg ctctgaacag agatgacttg   4380

ctgcatattg gaccagggaa taagaactat acttacatgg cccaggctgt gaacagaggg   4440

ctgacacttg tggggctttg ggaccggaga catccaggca tggcagatta tattcctgtt   4500

gctgtagagc atgccattga gccagacacc aagcttacct ttgttggaga tatcatctgc   4560

ttcagtactc accttgtcag ccagcatggt gaacctggga tatggatgat ttctgccaac   4620

aatattctac agacagacat tgtcactgga gtaggagtgg ccaggagtcc ggggactgca   4680

atgatttttc atgacatccc aggagtagtg aaaacatatc gagaggtggt ggtcaatgca   4740

tcatcaagat taatgctcag ttatgacctc aagacttatc tcaccaatac cctcaattca   4800

actgtattca agctcttcat caccactggc agaaatggtg tcaatcttaa aggattctgt   4860

accccaaacc aggccttggc cattacaaaa gtacttcttc cagcgaccct catgctgtgc   4920

catgtacagt tcagtaatac tttgctagac attccagcaa gtaaagtctt tcaggtccat   4980

tcagatttca gtatggagaa aggggtttat gtctgcataa tcaaggttcg accgcagtca   5040

gaggagctgc tacaggccct cagtgtggct gacacctcag tctatgggtg ggctacactg   5100

gtcagtgaac gtagcaagaa tggaatgcaa cgaatcctca ttcctttcat cccagccttt   5160

tatattaacc agtcagaatt ggttcttagc cacaaacaag atatcgggga gataagagta   5220

ctgggagtgg acagagttct taggaagcta gaggtcatct ccagctcccc agttctagtg   5280

gtcgctggcc atagccactc tcccctcact cctggcctgg ccatttactc tgtaagagtg   5340

gtcaacttca cttccttcca gcaaatggca tcacctgttt tcatcaatat ttcctgtgta   5400

ctcaccagtc aaagtgaggc agtggtagtg agggctatga aagataagtt gggtgcagat   5460

cactgtgaag attccgccat cctcaagcgg ttcactggct cttaccagat cctgctcttg   5520

accctctttg cagtgctggc atcaacagct tccatcttcc tagcatacaa tgccttccta   5580

aacaagatac aaacagttcc agttgtgtat gtaccaactc taggaacacc acagccaggt   5640

ttttttaact ccacaagttc tccccctcac ttcatgagtc tacaacctcc attggcccaa   5700

agtcggctgc aacattggtt atggagtata aggcactaac ctctgcttgg acaagtttct   5760

cttaactgca ggggaatgaa gatttctagt cctcgacaag aagcctaaca gcaacttcta   5820

cattaagttt ccagataagg cttctgagaa ctataaataa agcatcctaa gctgtttctt   5880

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa                                5913


<210>  33
<211>  1888
<212>  PRT
<213>  Homo sapiens

<400>  33


Met Thr Gly Cys Pro Ala Ser Ser Arg Arg Arg Gly Phe Gly Leu Phe 
1               5                   10                  15      


Phe Phe Leu Arg Leu His Arg Leu Leu Leu Leu Phe Leu Val Leu Arg 
            20                  25                  30          


Gly Thr Leu Ala Asn Lys Leu Asn Val Pro Gln Val Leu Leu Pro Phe 
        35                  40                  45              


Gly Arg Glu Pro Gly Arg Val Pro Phe Leu Leu Glu Ala Gln Arg Gly 
    50                  55                  60                  


Cys Tyr Thr Trp His Ser Thr His His Asp Ala Val Thr Val Glu Pro 
65                  70                  75                  80  


Leu Tyr Glu Asn Gly Thr Leu Cys Ser Gln Lys Ala Val Leu Ile Ala 
                85                  90                  95      


Glu Ser Thr Gln Pro Ile Arg Leu Ser Ser Ile Ile Leu Ala Arg Glu 
            100                 105                 110         


Ile Val Thr Asp His Glu Leu Arg Cys Asp Val Lys Val Asp Val Ile 
        115                 120                 125             


Asn Ser Ile Glu Ile Val Ser Arg Ala Arg Glu Leu Tyr Val Asp Asp 
    130                 135                 140                 


Ser Pro Leu Glu Leu Met Val Arg Ala Leu Asp Ala Glu Gly Asn Thr 
145                 150                 155                 160 


Phe Ser Ser Leu Ala Gly Met Met Phe Glu Trp Ser Ile Ala Gln Asp 
                165                 170                 175     


Asn Glu Ser Ala Arg Glu Glu Leu Ser Ser Lys Ile Arg Ile Leu Lys 
            180                 185                 190         


Tyr Ser Glu Ala Glu Tyr Ala Pro Pro Ile Tyr Ile Ala Glu Met Glu 
        195                 200                 205             


Lys Glu Glu Lys Gln Gly Asp Val Ile Leu Val Ser Gly Ile Arg Thr 
    210                 215                 220                 


Gly Ala Ala Val Val Lys Val Arg Ile His Glu Pro Phe Tyr Lys Lys 
225                 230                 235                 240 


Val Ala Ala Ala Leu Ile Arg Leu Leu Val Leu Glu Asn Ile Phe Leu 
                245                 250                 255     


Ile Pro Ser His Asp Ile Tyr Leu Leu Val Gly Thr Tyr Ile Lys Tyr 
            260                 265                 270         


Gln Val Ala Lys Met Val Gln Gly Arg Val Thr Glu Val Lys Phe Pro 
        275                 280                 285             


Leu Glu His Tyr Ile Leu Glu Leu Gln Asp His Arg Val Ala Leu Asn 
    290                 295                 300                 


Gly Ser His Ser Glu Lys Val Ala Ile Leu Asp Asp Lys Thr Ala Met 
305                 310                 315                 320 


Val Thr Ala Ser Gln Leu Gly Gln Thr Asn Leu Val Phe Val His Lys 
                325                 330                 335     


Asn Val His Met Arg Ser Val Ser Gly Leu Pro Asn Cys Thr Ile Tyr 
            340                 345                 350         


Val Val Glu Pro Gly Phe Leu Gly Phe Thr Val Gln Pro Gly Asn Arg 
        355                 360                 365             


Trp Ser Leu Glu Val Gly Gln Val Tyr Val Ile Thr Val Asp Val Phe 
    370                 375                 380                 


Asp Lys Ser Ser Thr Lys Val Tyr Ile Ser Asp Asn Leu Arg Ile Thr 
385                 390                 395                 400 


Tyr Asp Phe Pro Lys Glu Tyr Phe Glu Glu Gln Leu Thr Thr Val Asn 
                405                 410                 415     


Gly Ser Tyr His Ile Val Lys Ala Leu Lys Asp Gly Val Val Val Ile 
            420                 425                 430         


Asn Ala Ser Leu Thr Ser Ile Ile Tyr Gln Asn Lys Asp Ile Gln Pro 
        435                 440                 445             


Ile Lys Phe Leu Ile Lys His Gln Gln Glu Val Lys Ile Tyr Phe Pro 
    450                 455                 460                 


Ile Met Leu Thr Pro Lys Phe Leu Ala Phe Pro His His Pro Met Gly 
465                 470                 475                 480 


Met Leu Tyr Arg Tyr Lys Val Gln Val Glu Gly Gly Ser Gly Asn Phe 
                485                 490                 495     


Thr Trp Thr Ser Ser Asn Glu Thr Val Val Ile Val Thr Thr Lys Gly 
            500                 505                 510         


Val Val Thr Ala Gly Gln Val Arg Gly Asn Ser Thr Val Leu Ala Arg 
        515                 520                 525             


Asp Val Gln Asn Pro Phe Arg Tyr Gly Glu Ile Lys Ile His Val Leu 
    530                 535                 540                 


Lys Leu Asn Lys Met Glu Leu Leu Pro Phe His Ala Asp Val Glu Ile 
545                 550                 555                 560 


Gly Gln Ile Ile Glu Ile Pro Ile Ala Met Tyr His Ile Asn Lys Glu 
                565                 570                 575     


Thr Lys Glu Ala Met Ala Phe Thr Asp Cys Ser His Leu Ser Leu Asp 
            580                 585                 590         


Leu Asn Met Asp Lys Gln Gly Val Phe Thr Leu Leu Lys Glu Gly Ile 
        595                 600                 605             


Gln Arg Pro Gly Pro Met His Cys Ser Ser Thr His Ile Ala Ala Lys 
    610                 615                 620                 


Ser Leu Gly His Thr Leu Val Thr Val Ser Val Asn Glu Cys Asp Lys 
625                 630                 635                 640 


Tyr Leu Glu Ser Ser Ala Thr Phe Ala Ala Tyr Glu Pro Leu Lys Ala 
                645                 650                 655     


Leu Asn Pro Val Glu Val Ala Leu Val Thr Trp Gln Ser Val Lys Glu 
            660                 665                 670         


Met Val Phe Glu Gly Gly Pro Arg Pro Trp Ile Leu Glu Pro Ser Arg 
        675                 680                 685             


Phe Phe Leu Glu Leu Asn Ala Glu Lys Thr Glu Lys Ile Gly Ile Ala 
    690                 695                 700                 


Gln Val Trp Leu Pro Ser Lys Arg Lys Gln Asn Gln Tyr Ile Tyr Arg 
705                 710                 715                 720 


Ile Gln Cys Leu Asp Leu Gly Glu Gln Val Leu Thr Phe Arg Ile Gly 
                725                 730                 735     


Asn His Pro Gly Val Leu Asn Pro Ser Pro Ala Val Glu Val Leu Gln 
            740                 745                 750         


Val Arg Phe Ile Cys Ala His Pro Ala Ser Met Ser Val Thr Pro Val 
        755                 760                 765             


Tyr Lys Val Pro Ala Gly Ala Gln Pro Cys Pro Leu Pro Gln His Asn 
    770                 775                 780                 


Lys Trp Leu Ile Pro Val Ser Arg Leu Arg Asp Thr Val Leu Glu Leu 
785                 790                 795                 800 


Ala Val Phe Asp Gln His Arg Arg Lys Phe Asp Asn Phe Ser Ser Leu 
                805                 810                 815     


Met Leu Glu Trp Lys Ser Ser Asn Glu Thr Leu Ala His Phe Glu Asp 
            820                 825                 830         


Tyr Lys Ser Val Glu Met Val Ala Lys Asp Asp Gly Ser Gly Gln Thr 
        835                 840                 845             


Arg Leu His Gly His Gln Ile Leu Lys Val His Gln Ile Lys Gly Thr 
    850                 855                 860                 


Val Leu Ile Gly Val Asn Phe Val Gly Tyr Ser Glu Lys Lys Ser Pro 
865                 870                 875                 880 


Lys Glu Ile Ser Asn Leu Pro Arg Ser Val Asp Val Glu Leu Leu Leu 
                885                 890                 895     


Val Asp Asp Val Thr Val Val Pro Glu Asn Ala Thr Ile Tyr Asn His 
            900                 905                 910         


Pro Asp Val Lys Glu Thr Phe Ser Leu Val Glu Gly Ser Gly Tyr Phe 
        915                 920                 925             


Leu Val Asn Ser Ser Glu Gln Gly Val Val Thr Ile Thr Tyr Met Glu 
    930                 935                 940                 


Ala Glu Ser Ser Val Glu Leu Val Pro Leu His Pro Gly Phe Phe Thr 
945                 950                 955                 960 


Leu Glu Val Tyr Asp Leu Cys Leu Ala Phe Leu Gly Pro Ala Thr Ala 
                965                 970                 975     


His Leu Arg Val Ser Asp Ile Gln Glu Leu Glu Leu Asp Leu Ile Asp 
            980                 985                 990         


Lys Val Glu Ile Asp Lys Thr Val  Leu Val Thr Val Arg  Val Leu Gly 
        995                 1000                 1005             


Ser Ser  Lys Arg Pro Phe Gln  Asn Lys Tyr Phe Arg  Asn Met Glu 
    1010                 1015                 1020             


Leu Lys  Leu Gln Leu Ala Ser  Ala Ile Val Thr Leu  Thr Pro Met 
    1025                 1030                 1035             


Glu Gln  Gln Asp Glu Tyr Ser  Glu Asn Tyr Ile Leu  Arg Ala Thr 
    1040                 1045                 1050             


Thr Ile  Gly Gln Thr Thr Leu  Val Ala Ile Ala Lys  Asp Lys Met 
    1055                 1060                 1065             


Gly Arg  Lys Tyr Thr Ser Thr  Pro Arg His Ile Glu  Val Phe Pro 
    1070                 1075                 1080             


Pro Phe  Arg Leu Leu Pro Glu  Lys Met Thr Leu Ile  Pro Met Asn 
    1085                 1090                 1095             


Met Met  Gln Val Met Ser Glu  Gly Gly Pro Gln Pro  Gln Ser Ile 
    1100                 1105                 1110             


Val His  Phe Ser Ile Ser Asn  Gln Thr Val Ala Val  Val Asn Arg 
    1115                 1120                 1125             


Arg Gly  Gln Val Thr Gly Lys  Ile Val Gly Thr Ala  Val Val His 
    1130                 1135                 1140             


Gly Thr  Ile Gln Thr Val Asn  Glu Asp Thr Gly Lys  Val Ile Val 
    1145                 1150                 1155             


Phe Ser  Gln Asp Glu Val Gln  Ile Glu Val Val Gln  Leu Arg Ala 
    1160                 1165                 1170             


Val Arg  Ile Leu Ala Ala Ala  Thr Arg Leu Ile Thr  Ala Thr Lys 
    1175                 1180                 1185             


Met Pro  Val Tyr Val Met Gly  Val Thr Ser Thr Gln  Thr Pro Phe 
    1190                 1195                 1200             


Ser Phe  Ser Asn Ala Asn Pro  Gly Leu Thr Phe His  Trp Ser Met 
    1205                 1210                 1215             


Ser Lys  Arg Asp Val Leu Asp  Leu Val Pro Arg His  Ser Glu Val 
    1220                 1225                 1230             


Phe Leu  Gln Leu Pro Val Glu  His Asn Phe Ala Met  Val Val His 
    1235                 1240                 1245             


Thr Lys  Ala Ala Gly Arg Thr  Ser Ile Lys Val Thr  Val His Cys 
    1250                 1255                 1260             


Met Asn  Ser Ser Ser Gly Gln  Phe Glu Gly Asn Leu  Leu Glu Leu 
    1265                 1270                 1275             


Ser Asp  Glu Val Gln Ile Leu  Val Phe Glu Lys Leu  Gln Leu Phe 
    1280                 1285                 1290             


Tyr Pro  Glu Cys Gln Pro Glu  Gln Ile Leu Met Pro  Ile Asn Ser 
    1295                 1300                 1305             


Gln Leu  Lys Leu His Thr Asn  Arg Glu Gly Ala Ala  Phe Val Ser 
    1310                 1315                 1320             


Ser Arg  Val Leu Lys Cys Phe  Pro Asn Ser Ser Val  Ile Glu Glu 
    1325                 1330                 1335             


Asp Gly  Glu Gly Leu Leu Lys  Ala Gly Ser Ile Ala  Gly Thr Ala 
    1340                 1345                 1350             


Val Leu  Glu Val Thr Ser Ile  Glu Pro Phe Gly Val  Asn Gln Thr 
    1355                 1360                 1365             


Thr Ile  Thr Gly Val Gln Val  Ala Pro Val Thr Tyr  Leu Arg Val 
    1370                 1375                 1380             


Ser Ser  Gln Pro Lys Leu Tyr  Thr Ala Gln Gly Arg  Thr Leu Ser 
    1385                 1390                 1395             


Ala Phe  Pro Leu Gly Met Ser  Leu Thr Phe Thr Val  Gln Phe Tyr 
    1400                 1405                 1410             


Asn Ser  Ile Gly Glu Lys Phe  His Thr His Asn Thr  Gln Leu Tyr 
    1415                 1420                 1425             


Leu Ala  Leu Asn Arg Asp Asp  Leu Leu His Ile Gly  Pro Gly Asn 
    1430                 1435                 1440             


Lys Asn  Tyr Thr Tyr Met Ala  Gln Ala Val Asn Arg  Gly Leu Thr 
    1445                 1450                 1455             


Leu Val  Gly Leu Trp Asp Arg  Arg His Pro Gly Met  Ala Asp Tyr 
    1460                 1465                 1470             


Ile Pro  Val Ala Val Glu His  Ala Ile Glu Pro Asp  Thr Lys Leu 
    1475                 1480                 1485             


Thr Phe  Val Gly Asp Ile Ile  Cys Phe Ser Thr His  Leu Val Ser 
    1490                 1495                 1500             


Gln His  Gly Glu Pro Gly Ile  Trp Met Ile Ser Ala  Asn Asn Ile 
    1505                 1510                 1515             


Leu Gln  Thr Asp Ile Val Thr  Gly Val Gly Val Ala  Arg Ser Pro 
    1520                 1525                 1530             


Gly Thr  Ala Met Ile Phe His  Asp Ile Pro Gly Val  Val Lys Thr 
    1535                 1540                 1545             


Tyr Arg  Glu Val Val Val Asn  Ala Ser Ser Arg Leu  Met Leu Ser 
    1550                 1555                 1560             


Tyr Asp  Leu Lys Thr Tyr Leu  Thr Asn Thr Leu Asn  Ser Thr Val 
    1565                 1570                 1575             


Phe Lys  Leu Phe Ile Thr Thr  Gly Arg Asn Gly Val  Asn Leu Lys 
    1580                 1585                 1590             


Gly Phe  Cys Thr Pro Asn Gln  Ala Leu Ala Ile Thr  Lys Val Leu 
    1595                 1600                 1605             


Leu Pro  Ala Thr Leu Met Leu  Cys His Val Gln Phe  Ser Asn Thr 
    1610                 1615                 1620             


Leu Leu  Asp Ile Pro Ala Ser  Lys Val Phe Gln Val  His Ser Asp 
    1625                 1630                 1635             


Phe Ser  Met Glu Lys Gly Val  Tyr Val Cys Ile Ile  Lys Val Arg 
    1640                 1645                 1650             


Pro Gln  Ser Glu Glu Leu Leu  Gln Ala Leu Ser Val  Ala Asp Thr 
    1655                 1660                 1665             


Ser Val  Tyr Gly Trp Ala Thr  Leu Val Ser Glu Arg  Ser Lys Asn 
    1670                 1675                 1680             


Gly Met  Gln Arg Ile Leu Ile  Pro Phe Ile Pro Ala  Phe Tyr Ile 
    1685                 1690                 1695             


Asn Gln  Ser Glu Leu Val Leu  Ser His Lys Gln Asp  Ile Gly Glu 
    1700                 1705                 1710             


Ile Arg  Val Leu Gly Val Asp  Arg Val Leu Arg Lys  Leu Glu Val 
    1715                 1720                 1725             


Ile Ser  Ser Ser Pro Val Leu  Val Val Ala Gly His  Ser His Ser 
    1730                 1735                 1740             


Pro Leu  Thr Pro Gly Leu Ala  Ile Tyr Ser Val Arg  Val Val Asn 
    1745                 1750                 1755             


Phe Thr  Ser Phe Gln Gln Met  Ala Ser Pro Val Phe  Ile Asn Ile 
    1760                 1765                 1770             


Ser Cys  Val Leu Thr Ser Gln  Ser Glu Ala Val Val  Val Arg Ala 
    1775                 1780                 1785             


Met Lys  Asp Lys Leu Gly Ala  Asp His Cys Glu Asp  Ser Ala Ile 
    1790                 1795                 1800             


Leu Lys  Arg Phe Thr Gly Ser  Tyr Gln Ile Leu Leu  Leu Thr Leu 
    1805                 1810                 1815             


Phe Ala  Val Leu Ala Ser Thr  Ala Ser Ile Phe Leu  Ala Tyr Asn 
    1820                 1825                 1830             


Ala Phe  Leu Asn Lys Ile Gln  Thr Val Pro Val Val  Tyr Val Pro 
    1835                 1840                 1845             


Thr Leu  Gly Thr Pro Gln Pro  Gly Phe Phe Asn Ser  Thr Ser Ser 
    1850                 1855                 1860             


Pro Pro  His Phe Met Ser Leu  Gln Pro Pro Leu Ala  Gln Ser Arg 
    1865                 1870                 1875             


Leu Gln  His Trp Leu Trp Ser  Ile Arg His 
    1880                 1885             

<210>  34
<211>  3212
<212>  DNA
<213>  Homo sapiens

<400>  34
gtcacatccg ggcgggttgg tgagttccgg tatttcaggg cgtagcaggc ggaagtaagg     60

gtgagaggag gctgcaacgc cgagcggagg aggcaggaac cggagcgcga gcagtagctg    120

ggtgggcacc atggctggga tcaccaccat cgaggcggtg aagcgcaaga tccaggttct    180

gcagcagcag gcagatgatg cagaggagcg agctgagcgc ctccagcgag aagttgaggg    240

agaaaggcgg gcccgggaac aggctgaggc tgaggtggcc tccttgaacc gtaggatcca    300

gctggttgaa gaagagctgg accgtgctca ggagcgcctg gccactgccc tgcaaaagct    360

ggaagaagct gaaaaagctg ctgatgagag tgagagaggt atgaaggtta ttgaaaaccg    420

ggccttaaaa gatgaagaaa agatggaact ccaggaaatc caactcaaag aagctaagca    480

cattgcagaa gaggcagata ggaagtatga agaggtggct cgtaagttgg tgatcattga    540

aggagacttg gaacgcacag aggaacgagc tgagctggca gagtctaagt gttctgagct    600

ggaggaggag ctgaagaatg tcaccaacaa cctcaagtct cttgaggctc aggcggagaa    660

gtactctcaa aaagaagata aatatgagga agaaatcaag attcttactg ataaactcaa    720

ggaggcagag acccgtgctg agtttgctga gagatcggta gccaagctgg aaaagacaat    780

tgatgacctg gaagataaac tgaaatgcac caaagaggag cacctctgta cacaaaggat    840

gctggaccag accctgcttg acctgaatga gatgtagaac gccccagtcc caccctgctg    900

ctgctcctcc ctctgaccca gactccgcct gaggccagcc tgcgggaagc tgacctttaa    960

ctgagggctg atctttaact ggaaggctgc tttctccttt caccaccccc tccttccctg   1020

tgtctttttc gccaaactgt ctctgcctct tcccggagaa tccagctggg ctagaggctg   1080

agcacctttg gaaacaacat ttaagggaat gtgagcacaa tgcataatgt ctttaaaaag   1140

catgttgtga tgtacacatt ttgtaattac cttttttgtt gttttgtagc aaccatttgt   1200

aaaacattcc aaataattcc acagtcctga agcagcaatc gaatcccttt ctcacttttg   1260

gaaggtgact tttcacctta atgcatattc ccctctccat agaggagagg aaaaggtgta   1320

ggcctgcctt accgagagcc aaacagagcc cagggagact ccgctgtggg aaacctcatt   1380

gttctgtaca aagtactagc taaaccagaa aggtgattcc aggaggagtt agccaaacaa   1440

caacaaaaac aaaaaatgtg ctgttcaagt tttcagcttt aagatatctt tggataatgt   1500

tatttctatt ttttattttt ttcattagaa gttaccaaat taagatggta agacctctga   1560

gaccaaaatt ttgtcccatc tctaccccct cacaactgct tacagaatgg atcatgtccc   1620

ccttatgttg aggtgaccac ttaattgctt tcctgcctcc ttgaaagaaa gaaagaaaga   1680

agactgtgtt tttgccactg atttagccat gtgaaactca tctcattacc cttttctggg   1740

tttgaagctg ctgtctctag aagtgccatc tcaattgtgc tttgtatcag tcagtgctgg   1800

agaaatcttg aatagcttat gtacaaaact ttttaaattt tatattattt tgaaactttg   1860

ctttgggttt gtggcaccct ggccacccca tctggctgtg acagcctctg cagtccgtgg   1920

gctggcagtt tgttgatctt ttaagtttcc ttccctaccc agtccccatt ttctggtaag   1980

gtttctagga ggtctgttag gtgtacatcc tgcagcttat tggcttaaaa tgtactctcc   2040

ttttatgtgg tctctttggg gccgattggg agaaagagaa atcaatagtg caactgtttt   2100

gatactgaat attgacaagt gtctttttga aataaagaac cagtccctcc aaccctcaga   2160

cctatttgac ttttatttat taaaactaaa tgtgctttct ccacagaagc tatgaggttt   2220

gggttaaaaa tagcatcttt gtgggtggta gcaacaggat ttattcttta ttattattat   2280

ttttgagatg aagtttcatt cttgttgcct gggctggagc gtaatggctc gatctcggct   2340

cactgcaacc tccgcctcct ggttcaagag attctcctgc ctcagcctcc cgagtagctg   2400

ggattacagg cacctgccac catgcccggg taatttttta tattttaagt agagacaggg   2460

cttcaccatg ttggccaggc tggtctcgaa ctcctgacct tcaggtgatc cacctgcctc   2520

agcttcccaa aatgctggga ttacgggcgt gagccaccgc acccagctgg agcaacagga   2580

tttaatatag agcaaatgtt tagttttatc atctgtaaaa tggagataag tattgtcaga   2640

gtaaacatga agattagaaa gaacacttaa tgtgctgggc cttttatagg ttaacactga   2700

catctcaggc tgaactatat acattttcct tcacaaccat atcaatcctt ataaactatg   2760

gatttatgct ccttaaaaca atatataatg ctgatcacta ctataaatgc gtggttttaa   2820

ccaactgtac tgaaacagct ttgagtttat attctgtttg gatatttgga gaaaacaaca   2880

agtgctctca agagtatttg cttagaggcc ggctgtgtga gtggataact ttgaaagctg   2940

cttttgagac gccagtgtct ggcatttcct gcattctggc ctggaggccg gacgtgaatc   3000

tgacttctag taaaaataca cggttccctt gacaaagtcg agctgtttat cccagagact   3060

gcacaatttt ccgttgatag gcatggacca atgctaactg gaaatcattg caaaaagttt   3120

ttttgtcggg cggagggtgt ggtgttaaga taaacagtgt gcaacagaag aaattaaaac   3180

tggaagaaat taaagggttt tttttagact tt                                 3212


<210>  35
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  35


Met Ala Gly Ile Thr Thr Ile Glu Ala Val Lys Arg Lys Ile Gln Val 
1               5                   10                  15      


Leu Gln Gln Gln Ala Asp Asp Ala Glu Glu Arg Ala Glu Arg Leu Gln 
            20                  25                  30          


Arg Glu Val Glu Gly Glu Arg Arg Ala Arg Glu Gln Ala Glu Ala Glu 
        35                  40                  45              


Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu Glu Glu Leu Asp 
    50                  55                  60                  


Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys Leu Glu Glu Ala 
65                  70                  75                  80  


Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys Val Ile Glu Asn 
                85                  90                  95      


Arg Ala Leu Lys Asp Glu Glu Lys Met Glu Leu Gln Glu Ile Gln Leu 
            100                 105                 110         


Lys Glu Ala Lys His Ile Ala Glu Glu Ala Asp Arg Lys Tyr Glu Glu 
        115                 120                 125             


Val Ala Arg Lys Leu Val Ile Ile Glu Gly Asp Leu Glu Arg Thr Glu 
    130                 135                 140                 


Glu Arg Ala Glu Leu Ala Glu Ser Lys Cys Ser Glu Leu Glu Glu Glu 
145                 150                 155                 160 


Leu Lys Asn Val Thr Asn Asn Leu Lys Ser Leu Glu Ala Gln Ala Glu 
                165                 170                 175     


Lys Tyr Ser Gln Lys Glu Asp Lys Tyr Glu Glu Glu Ile Lys Ile Leu 
            180                 185                 190         


Thr Asp Lys Leu Lys Glu Ala Glu Thr Arg Ala Glu Phe Ala Glu Arg 
        195                 200                 205             


Ser Val Ala Lys Leu Glu Lys Thr Ile Asp Asp Leu Glu Asp Lys Leu 
    210                 215                 220                 


Lys Cys Thr Lys Glu Glu His Leu Cys Thr Gln Arg Met Leu Asp Gln 
225                 230                 235                 240 


Thr Leu Leu Asp Leu Asn Glu Met 
                245             

<210>  36
<211>  4539
<212>  DNA
<213>  Homo sapiens

<400>  36
gtcacatccg ggcgggttgg tgagttccgg tatttcaggg cgtagcaggc ggaagtaagg     60

gtgagaggag gctgcaacgc cgagcggagg aggcaggaac cggagcgcga gcagtagctg    120

ggtgggcacc atggctggga tcaccaccat cgaggcggtg aagcgcaaga tccaggttct    180

gcagcagcag gcagatgatg cagaggagcg agctgagcgc ctccagcgag aagttgaggg    240

agaaaggcgg gcccgggaac aggctgaggc tgaggtggcc tccttgaacc gtaggatcca    300

gctggttgaa gaagagctgg accgtgctca ggagcgcctg gccactgccc tgcaaaagct    360

ggaagaagct gaaaaagctg ctgatgagag tgagagaggt atgaaggtta ttgaaaaccg    420

ggccttaaaa gatgaagaaa agatggaact ccaggaaatc caactcaaag aagctaagca    480

cattgcagaa gaggcagata ggaagtatga agaggtggct cgtaagttgg tgatcattga    540

aggagacttg gaacgcacag aggaacgagc tgagctggca gagtcccgtt gccgagagat    600

ggatgagcag attagactga tggaccagaa cctgaagtgt ctgagtgctg ctgaagaaaa    660

gtactctcaa aaagaagata aatatgagga agaaatcaag attcttactg ataaactcaa    720

ggaggcagag acccgtgctg agtttgctga gagatcggta gccaagctgg aaaagacaat    780

tgatgacctg gaagagcgtc tctacagcca acttgagcga aaccgcctgc tttctaatga    840

gctgaagcta acgctgcatg atctgtgtga ctgatgggca gggctcaatg atgcccatta    900

aactgagctt actgctcaca ccactgacct ggaccccaac aaaaagctga ttgtcttttt    960

aaaagttatt attttgccct gagcaaattg cattttaatt ggggcagtta gaatgttgat   1020

ttcctaacag cattgtgaag ttgaccattg tgaagtttct gtccctttag aagagattat   1080

gggtgaagaa gggaggggcc tgagagatta tagtgagaaa acttgcgaga attttgtttt   1140

ccacccttat ttgctgctct ttcacttggg cactgactgt aggatatgtt cccttgcatg   1200

gatgttttta acaataaaag gactgacttg acaagttgtt gtaactgctt catcggcagg   1260

cccaggaatg ggtccttctg actgggtgga aaaaagggaa gtgaaagaaa agttgtggga   1320

tatgaatatg ggtctgtgtt gccatcacct tctctgagtt gaagatttga gtattttcct   1380

cacctcttta gagcagtcag agtggtttgc ttgctagaca gattagattc tccttaatgt   1440

tcagctgctg attttctttc tgacttttgc gtcctttttc tggttttatg ttaatttcaa   1500

gtaactgtca caagctagtt ctgttcaata gctctgcagc aatctcaagg tttgcttaca   1560

actacttgtt tcagtagtat tcttggcttt gttttcttta gagattattt gacttaactg   1620

tgagcgccct tttatttatc ccatcagtta ttactttggc ctctactttt tcgaaaaaac   1680

atgtagtgca tgaggatctt cctgtgctct ttataatctg agattctgat gtttctattg   1740

tttgcaatgt tcaaactccg gtgagccatt tcaagagggt attgttatgt gggcaaaacc   1800

tagaaaagtg gatggctgat ggttaaggct tgctctttca ttgactgaaa gctgaaagtg   1860

ttggttgggt gtgggaggga gaggaaatgg ctgataaggg ccctaactcc ctcacccagg   1920

aagtgcagca acacctacaa cttcagtagg caagccaaag gccctacaaa actgggtgat   1980

gtaatagctc acttctgtgg ctgagaaggc agctgcttta tcagtctgca gcttctctgc   2040

aacaggagca agtctcaaag agcgggtaga ccttgaaatt tacttctagt tcttgtaact   2100

tctctccttt acccccatta gataaactga aatgcaccaa agaggagcac ctctgtacac   2160

aaaggatgct ggaccagacc ctgcttgacc tgaatgagat gtagaacgcc ccagtcccac   2220

cctgctgctg ctcctccctc tgacccagac tccgcctgag gccagcctgc gggaagctga   2280

cctttaactg agggctgatc tttaactgga aggctgcttt ctcctttcac caccccctcc   2340

ttccctgtgt ctttttcgcc aaactgtctc tgcctcttcc cggagaatcc agctgggcta   2400

gaggctgagc acctttggaa acaacattta agggaatgtg agcacaatgc ataatgtctt   2460

taaaaagcat gttgtgatgt acacattttg taattacctt ttttgttgtt ttgtagcaac   2520

catttgtaaa acattccaaa taattccaca gtcctgaagc agcaatcgaa tccctttctc   2580

acttttggaa ggtgactttt caccttaatg catattcccc tctccataga ggagaggaaa   2640

aggtgtaggc ctgccttacc gagagccaaa cagagcccag ggagactccg ctgtgggaaa   2700

cctcattgtt ctgtacaaag tactagctaa accagaaagg tgattccagg aggagttagc   2760

caaacaacaa caaaaacaaa aaatgtgctg ttcaagtttt cagctttaag atatctttgg   2820

ataatgttat ttctattttt tatttttttc attagaagtt accaaattaa gatggtaaga   2880

cctctgagac caaaattttg tcccatctct accccctcac aactgcttac agaatggatc   2940

atgtccccct tatgttgagg tgaccactta attgctttcc tgcctccttg aaagaaagaa   3000

agaaagaaga ctgtgttttt gccactgatt tagccatgtg aaactcatct cattaccctt   3060

ttctgggttt gaagctgctg tctctagaag tgccatctca attgtgcttt gtatcagtca   3120

gtgctggaga aatcttgaat agcttatgta caaaactttt taaattttat attattttga   3180

aactttgctt tgggtttgtg gcaccctggc caccccatct ggctgtgaca gcctctgcag   3240

tccgtgggct ggcagtttgt tgatctttta agtttccttc cctacccagt ccccattttc   3300

tggtaaggtt tctaggaggt ctgttaggtg tacatcctgc agcttattgg cttaaaatgt   3360

actctccttt tatgtggtct ctttggggcc gattgggaga aagagaaatc aatagtgcaa   3420

ctgttttgat actgaatatt gacaagtgtc tttttgaaat aaagaaccag tccctccaac   3480

cctcagacct atttgacttt tatttattaa aactaaatgt gctttctcca cagaagctat   3540

gaggtttggg ttaaaaatag catctttgtg ggtggtagca acaggattta ttctttatta   3600

ttattatttt tgagatgaag tttcattctt gttgcctggg ctggagcgta atggctcgat   3660

ctcggctcac tgcaacctcc gcctcctggt tcaagagatt ctcctgcctc agcctcccga   3720

gtagctggga ttacaggcac ctgccaccat gcccgggtaa ttttttatat tttaagtaga   3780

gacagggctt caccatgttg gccaggctgg tctcgaactc ctgaccttca ggtgatccac   3840

ctgcctcagc ttcccaaaat gctgggatta cgggcgtgag ccaccgcacc cagctggagc   3900

aacaggattt aatatagagc aaatgtttag ttttatcatc tgtaaaatgg agataagtat   3960

tgtcagagta aacatgaaga ttagaaagaa cacttaatgt gctgggcctt ttataggtta   4020

acactgacat ctcaggctga actatataca ttttccttca caaccatatc aatccttata   4080

aactatggat ttatgctcct taaaacaata tataatgctg atcactacta taaatgcgtg   4140

gttttaacca actgtactga aacagctttg agtttatatt ctgtttggat atttggagaa   4200

aacaacaagt gctctcaaga gtatttgctt agaggccggc tgtgtgagtg gataactttg   4260

aaagctgctt ttgagacgcc agtgtctggc atttcctgca ttctggcctg gaggccggac   4320

gtgaatctga cttctagtaa aaatacacgg ttcccttgac aaagtcgagc tgtttatccc   4380

agagactgca caattttccg ttgataggca tggaccaatg ctaactggaa atcattgcaa   4440

aaagtttttt tgtcgggcgg agggtgtggt gttaagataa acagtgtgca acagaagaaa   4500

ttaaaactgg aagaaattaa agggtttttt ttagacttt                          4539


<210>  37
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  37


Met Ala Gly Ile Thr Thr Ile Glu Ala Val Lys Arg Lys Ile Gln Val 
1               5                   10                  15      


Leu Gln Gln Gln Ala Asp Asp Ala Glu Glu Arg Ala Glu Arg Leu Gln 
            20                  25                  30          


Arg Glu Val Glu Gly Glu Arg Arg Ala Arg Glu Gln Ala Glu Ala Glu 
        35                  40                  45              


Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu Glu Glu Leu Asp 
    50                  55                  60                  


Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys Leu Glu Glu Ala 
65                  70                  75                  80  


Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys Val Ile Glu Asn 
                85                  90                  95      


Arg Ala Leu Lys Asp Glu Glu Lys Met Glu Leu Gln Glu Ile Gln Leu 
            100                 105                 110         


Lys Glu Ala Lys His Ile Ala Glu Glu Ala Asp Arg Lys Tyr Glu Glu 
        115                 120                 125             


Val Ala Arg Lys Leu Val Ile Ile Glu Gly Asp Leu Glu Arg Thr Glu 
    130                 135                 140                 


Glu Arg Ala Glu Leu Ala Glu Ser Arg Cys Arg Glu Met Asp Glu Gln 
145                 150                 155                 160 


Ile Arg Leu Met Asp Gln Asn Leu Lys Cys Leu Ser Ala Ala Glu Glu 
                165                 170                 175     


Lys Tyr Ser Gln Lys Glu Asp Lys Tyr Glu Glu Glu Ile Lys Ile Leu 
            180                 185                 190         


Thr Asp Lys Leu Lys Glu Ala Glu Thr Arg Ala Glu Phe Ala Glu Arg 
        195                 200                 205             


Ser Val Ala Lys Leu Glu Lys Thr Ile Asp Asp Leu Glu Glu Arg Leu 
    210                 215                 220                 


Tyr Ser Gln Leu Glu Arg Asn Arg Leu Leu Ser Asn Glu Leu Lys Leu 
225                 230                 235                 240 


Thr Leu His Asp Leu Cys Asp 
                245         

<210>  38
<211>  4539
<212>  DNA
<213>  Homo sapiens

<400>  38
gtcacatccg ggcgggttgg tgagttccgg tatttcaggg cgtagcaggc ggaagtaagg     60

gtgagaggag gctgcaacgc cgagcggagg aggcaggaac cggagcgcga gcagtagctg    120

ggtgggcacc atggctggga tcaccaccat cgaggcggtg aagcgcaaga tccaggttct    180

gcagcagcag gcagatgatg cagaggagcg agctgagcgc ctccagcgag aagttgaggg    240

agaaaggcgg gcccgggaac aggctgaggc tgaggtggcc tccttgaacc gtaggatcca    300

gctggttgaa gaagagctgg accgtgctca ggagcgcctg gccactgccc tgcaaaagct    360

ggaagaagct gaaaaagctg ctgatgagag tgagagaggt atgaaggtta ttgaaaaccg    420

ggccttaaaa gatgaagaaa agatggaact ccaggaaatc caactcaaag aagctaagca    480

cattgcagaa gaggcagata ggaagtatga agaggtggct cgtaagttgg tgatcattga    540

aggagacttg gaacgcacag aggaacgagc tgagctggca gagtctaagt gttctgagct    600

ggaggaggag ctgaagaatg tcaccaacaa cctcaagtct cttgaggctc aggcggagaa    660

gtactctcaa aaagaagata aatatgagga agaaatcaag attcttactg ataaactcaa    720

ggaggcagag acccgtgctg agtttgctga gagatcggta gccaagctgg aaaagacaat    780

tgatgacctg gaagagcgtc tctacagcca acttgagcga aaccgcctgc tttctaatga    840

gctgaagcta acgctgcatg atctgtgtga ctgatgggca gggctcaatg atgcccatta    900

aactgagctt actgctcaca ccactgacct ggaccccaac aaaaagctga ttgtcttttt    960

aaaagttatt attttgccct gagcaaattg cattttaatt ggggcagtta gaatgttgat   1020

ttcctaacag cattgtgaag ttgaccattg tgaagtttct gtccctttag aagagattat   1080

gggtgaagaa gggaggggcc tgagagatta tagtgagaaa acttgcgaga attttgtttt   1140

ccacccttat ttgctgctct ttcacttggg cactgactgt aggatatgtt cccttgcatg   1200

gatgttttta acaataaaag gactgacttg acaagttgtt gtaactgctt catcggcagg   1260

cccaggaatg ggtccttctg actgggtgga aaaaagggaa gtgaaagaaa agttgtggga   1320

tatgaatatg ggtctgtgtt gccatcacct tctctgagtt gaagatttga gtattttcct   1380

cacctcttta gagcagtcag agtggtttgc ttgctagaca gattagattc tccttaatgt   1440

tcagctgctg attttctttc tgacttttgc gtcctttttc tggttttatg ttaatttcaa   1500

gtaactgtca caagctagtt ctgttcaata gctctgcagc aatctcaagg tttgcttaca   1560

actacttgtt tcagtagtat tcttggcttt gttttcttta gagattattt gacttaactg   1620

tgagcgccct tttatttatc ccatcagtta ttactttggc ctctactttt tcgaaaaaac   1680

atgtagtgca tgaggatctt cctgtgctct ttataatctg agattctgat gtttctattg   1740

tttgcaatgt tcaaactccg gtgagccatt tcaagagggt attgttatgt gggcaaaacc   1800

tagaaaagtg gatggctgat ggttaaggct tgctctttca ttgactgaaa gctgaaagtg   1860

ttggttgggt gtgggaggga gaggaaatgg ctgataaggg ccctaactcc ctcacccagg   1920

aagtgcagca acacctacaa cttcagtagg caagccaaag gccctacaaa actgggtgat   1980

gtaatagctc acttctgtgg ctgagaaggc agctgcttta tcagtctgca gcttctctgc   2040

aacaggagca agtctcaaag agcgggtaga ccttgaaatt tacttctagt tcttgtaact   2100

tctctccttt acccccatta gataaactga aatgcaccaa agaggagcac ctctgtacac   2160

aaaggatgct ggaccagacc ctgcttgacc tgaatgagat gtagaacgcc ccagtcccac   2220

cctgctgctg ctcctccctc tgacccagac tccgcctgag gccagcctgc gggaagctga   2280

cctttaactg agggctgatc tttaactgga aggctgcttt ctcctttcac caccccctcc   2340

ttccctgtgt ctttttcgcc aaactgtctc tgcctcttcc cggagaatcc agctgggcta   2400

gaggctgagc acctttggaa acaacattta agggaatgtg agcacaatgc ataatgtctt   2460

taaaaagcat gttgtgatgt acacattttg taattacctt ttttgttgtt ttgtagcaac   2520

catttgtaaa acattccaaa taattccaca gtcctgaagc agcaatcgaa tccctttctc   2580

acttttggaa ggtgactttt caccttaatg catattcccc tctccataga ggagaggaaa   2640

aggtgtaggc ctgccttacc gagagccaaa cagagcccag ggagactccg ctgtgggaaa   2700

cctcattgtt ctgtacaaag tactagctaa accagaaagg tgattccagg aggagttagc   2760

caaacaacaa caaaaacaaa aaatgtgctg ttcaagtttt cagctttaag atatctttgg   2820

ataatgttat ttctattttt tatttttttc attagaagtt accaaattaa gatggtaaga   2880

cctctgagac caaaattttg tcccatctct accccctcac aactgcttac agaatggatc   2940

atgtccccct tatgttgagg tgaccactta attgctttcc tgcctccttg aaagaaagaa   3000

agaaagaaga ctgtgttttt gccactgatt tagccatgtg aaactcatct cattaccctt   3060

ttctgggttt gaagctgctg tctctagaag tgccatctca attgtgcttt gtatcagtca   3120

gtgctggaga aatcttgaat agcttatgta caaaactttt taaattttat attattttga   3180

aactttgctt tgggtttgtg gcaccctggc caccccatct ggctgtgaca gcctctgcag   3240

tccgtgggct ggcagtttgt tgatctttta agtttccttc cctacccagt ccccattttc   3300

tggtaaggtt tctaggaggt ctgttaggtg tacatcctgc agcttattgg cttaaaatgt   3360

actctccttt tatgtggtct ctttggggcc gattgggaga aagagaaatc aatagtgcaa   3420

ctgttttgat actgaatatt gacaagtgtc tttttgaaat aaagaaccag tccctccaac   3480

cctcagacct atttgacttt tatttattaa aactaaatgt gctttctcca cagaagctat   3540

gaggtttggg ttaaaaatag catctttgtg ggtggtagca acaggattta ttctttatta   3600

ttattatttt tgagatgaag tttcattctt gttgcctggg ctggagcgta atggctcgat   3660

ctcggctcac tgcaacctcc gcctcctggt tcaagagatt ctcctgcctc agcctcccga   3720

gtagctggga ttacaggcac ctgccaccat gcccgggtaa ttttttatat tttaagtaga   3780

gacagggctt caccatgttg gccaggctgg tctcgaactc ctgaccttca ggtgatccac   3840

ctgcctcagc ttcccaaaat gctgggatta cgggcgtgag ccaccgcacc cagctggagc   3900

aacaggattt aatatagagc aaatgtttag ttttatcatc tgtaaaatgg agataagtat   3960

tgtcagagta aacatgaaga ttagaaagaa cacttaatgt gctgggcctt ttataggtta   4020

acactgacat ctcaggctga actatataca ttttccttca caaccatatc aatccttata   4080

aactatggat ttatgctcct taaaacaata tataatgctg atcactacta taaatgcgtg   4140

gttttaacca actgtactga aacagctttg agtttatatt ctgtttggat atttggagaa   4200

aacaacaagt gctctcaaga gtatttgctt agaggccggc tgtgtgagtg gataactttg   4260

aaagctgctt ttgagacgcc agtgtctggc atttcctgca ttctggcctg gaggccggac   4320

gtgaatctga cttctagtaa aaatacacgg ttcccttgac aaagtcgagc tgtttatccc   4380

agagactgca caattttccg ttgataggca tggaccaatg ctaactggaa atcattgcaa   4440

aaagtttttt tgtcgggcgg agggtgtggt gttaagataa acagtgtgca acagaagaaa   4500

ttaaaactgg aagaaattaa agggtttttt ttagacttt                          4539


<210>  39
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  39


Met Ala Gly Ile Thr Thr Ile Glu Ala Val Lys Arg Lys Ile Gln Val 
1               5                   10                  15      


Leu Gln Gln Gln Ala Asp Asp Ala Glu Glu Arg Ala Glu Arg Leu Gln 
            20                  25                  30          


Arg Glu Val Glu Gly Glu Arg Arg Ala Arg Glu Gln Ala Glu Ala Glu 
        35                  40                  45              


Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu Glu Glu Leu Asp 
    50                  55                  60                  


Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys Leu Glu Glu Ala 
65                  70                  75                  80  


Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys Val Ile Glu Asn 
                85                  90                  95      


Arg Ala Leu Lys Asp Glu Glu Lys Met Glu Leu Gln Glu Ile Gln Leu 
            100                 105                 110         


Lys Glu Ala Lys His Ile Ala Glu Glu Ala Asp Arg Lys Tyr Glu Glu 
        115                 120                 125             


Val Ala Arg Lys Leu Val Ile Ile Glu Gly Asp Leu Glu Arg Thr Glu 
    130                 135                 140                 


Glu Arg Ala Glu Leu Ala Glu Ser Lys Cys Ser Glu Leu Glu Glu Glu 
145                 150                 155                 160 


Leu Lys Asn Val Thr Asn Asn Leu Lys Ser Leu Glu Ala Gln Ala Glu 
                165                 170                 175     


Lys Tyr Ser Gln Lys Glu Asp Lys Tyr Glu Glu Glu Ile Lys Ile Leu 
            180                 185                 190         


Thr Asp Lys Leu Lys Glu Ala Glu Thr Arg Ala Glu Phe Ala Glu Arg 
        195                 200                 205             


Ser Val Ala Lys Leu Glu Lys Thr Ile Asp Asp Leu Glu Glu Arg Leu 
    210                 215                 220                 


Tyr Ser Gln Leu Glu Arg Asn Arg Leu Leu Ser Asn Glu Leu Lys Leu 
225                 230                 235                 240 


Thr Leu His Asp Leu Cys Asp 
                245         

<210>  40
<211>  7116
<212>  DNA
<213>  Homo sapiens

<400>  40
agataaagac tcaagtctgg ggacctcctg gtcactcagg cagcagcccc ttctttcttg     60

ccccagtctc cagttctcca gtgttcacag gtgagcctac caacagccac tgctcatgat    120

ggaggccatc aagaaaaaga tgcagatgct gaagttagac aaggagaatg ctctggatcg    180

ggcagagcaa gctgaagctg agcagaagca ggcagaagaa agaagtaaac agctggagga    240

tgagctggca gccatgcaga agaagctgaa agggacagag gatgagctgg acaagtattc    300

tgaagctttg aaggatgccc aggagaagct ggaactggca gagaagaagg ctgctgatgc    360

tgaggctgag gtggcctcct tgaaccgtag gatccagctg gttgaagaag agctggaccg    420

tgctcaggag cgcctggcca ctgccctgca aaagctggaa gaagctgaaa aagctgctga    480

tgagagtgag agaggtatga aggttattga aaaccgggcc ttaaaagatg aagaaaagat    540

ggaactccag gaaatccaac tcaaagaagc taagcacatt gcagaagagg cagataggaa    600

gtatgaagag gtggctcgta agttggtgat cattgaagga gacttggaac gcacagagga    660

acgagctgag ctggcagagt ctaagtgttc tgagctggag gaggagctga agaatgtcac    720

caacaacctc aagtctcttg aggctcaggc ggagaagtac tctcaaaaag aagataaata    780

tgaggaagaa atcaagattc ttactgataa actcaaggag gcagagaccc gtgctgagtt    840

tgctgagaga tcggtagcca agctggaaaa gacaattgat gacctggaag atgagctcta    900

tgcccagaaa ctgaagtaca aggccattag cgaggagctg gaccacgccc tcaatgacat    960

gacctctata taattatcac cgtttctgct ctgttctgga tctgccccct ttactcctcg   1020

gggaacccaa ggccccactc tcgctctgga ttccatttgg gtcagcctgg ctggtcccca   1080

aggcattagg atgggggagc aaaaagcaac ttatgtattt tcttccaccc ccaccccaaa   1140

ttaaaatgtt aagctgctgg aaacctcatg ccaccctgca tttgtgtcat tgacaaagct   1200

gttgctgtcc ctaagaagga gccttggggg tgtgatgtgg ggaagagcta ttgtaggctc   1260

cccctcctct gacttatgta atcaaagcca cttttgtgtg tgtctatttt ttcttgacat   1320

ttaaactcag ctgatctgat tctaccagag tgatggattt agtacaggtt actcaggata   1380

gtaattttag ttatactcct caagctgaac aagattaaat tccttatttc caggttctta   1440

aatcatcctg cctgcagtgt ttccattctc tcttcaggta ttcctccttt ggtgtggtgt   1500

cattgagaag ccattgaagt gactctcaat acacattctg taccctttta ccggtggttc   1560

aaatggtgca tcctcagaac acccagtgaa cccaatacat tattgctaag attgactaat   1620

tatgtcaact ccagtcacag aaaaatacac aatggataga attctggacg gtttttttac   1680

tttttcttct ttaaaccttt cttacatatt tgagacttgc taccatttgc ctgctagtgt   1740

gtgactagtg ggatataaga taagtgataa attattattg ggaaaactaa aatgaccaat   1800

catgcatatt tcaaataatg tgcatatgag gctaatgatt tattacatac ataaatttct   1860

gctagtaaaa ttttccttgg ttcatattgt ggaattaaat atcaacattt tagaaattcc   1920

cattataggc cgggcgtggt agctcacgcc tataatccca gcactttggg aggctggggc   1980

aggtggatca cctgaggtca tgagttcgag accagctcgg ccaacatggt gaaaccccgt   2040

ctctactaaa aatacaaaaa ttagctgggc atggtgggtg ggtgcctgta atcccagcta   2100

ctcgggaggc tgaggcagga gaatcgcttg cacctgggag gcggaggttg cagtgagcgg   2160

agatcgcgcc actgcattcc agcctgggca acagagagac tccatctcaa aaaaaaaaaa   2220

ggaattcgca ttccaattta cacagcagag atttcttaat agtatagctg tgaattatac   2280

taatccaagc acgtaagtgt tgttcactta gtactttagt ttcccagcag ggtatgtatt   2340

taaaatttgc ttttctttta gctgggtgca atggcacttg cctgtactgc ctgtagcttc   2400

ttgggaggct gaggcaggag gattgcttga gcccaggagt tctgcactgt agtgtgctat   2460

gcaggtcaga tgtcctcact aaatttggca tcagtatggt gacctcctgg gagtggagaa   2520

caacaaggtt gcctaagaag gggtgaactg gcccaggtcg gaaatggagc aggtcaaaat   2580

tcctgtgctg atcagtagtg ggattgcacc tataaatagc cactgtagta ctccagcctg   2640

ggcaacacag caagattcca tctgttaaaa acacttttgc tcttctttta aacagatata   2700

atcaggtagg gaagttttcc ttaatctaaa actttaagtc atatcaaatt cacgtttcct   2760

tttgtccatt ccatttctta ctgccgcata gcctttgaga ttaaggttca gattcattta   2820

ttcagctgac acttcctggt atcttctagg tataggatat taagatggag acagaaataa   2880

agatggaggc accattccta ctctcaagtt gcttagaatc tactaggaga gaaaacatac   2940

ataaagctac agatactgtg tgatgaatgc cacaaataat agtgttatgg gaattgagta   3000

gaggggacga gattgatcct agtgggaatg aattggaaaa actcatggaa gaaggcatgt   3060

aatgggtact tcataaacat gttaaaactt ttttcttttt ttcttttttt tttttttttt   3120

gagacggagt ttgactcttg tcacctaggc tggagttcag tggcctgatc tcagctcact   3180

gcaacctctg cctcctgggt tcaagcagtt ctcccacctc agcctcccga gtagctgaga   3240

tcacaggcgc ctgccaccac acccagctaa tttttgtatt attagtagag gtgaggtttc   3300

accatgttgg ccaggctggt ctggaactcc tgacctcaag tgatccaccc acctcagcct   3360

cccaaagtga tgggattaca ggcttgagcc actgcgccca gccaacatgt taaacttgca   3420

tattcatttt tattgggttc caaaagtgga tttttgacaa gcagagttgg gttgtgggat   3480

agtgaatatt gagcattcca ttatttattt atttttctct ttttgagatg gagtctcgct   3540

ctgtcaccca ggctggatgg agtgcagtgg tgagatcatg gctcactgca acctctgctt   3600

cttgagttca agcgattctc ctgtctcagc ttcccgagga gctgtgatta cagataccca   3660

ccaccatgcc cagctgattt ttgtattttt agtacggacg gggtttcagc atgttggcca   3720

ggctggtcgc gaactcctga cctcaagtga tccacccgcc tctgcctccc aaagtgttgg   3780

gattacaggc gtgagccact gcacctggcc tgagcattcc atttaaagag aaacaaaata   3840

ataaaggcat tgatagagat gagaaggcca caatagctct aaaggtagat ttagacagag   3900

tagggaacag gttgtgtctt aaaatgaggc tgaggagtta taattttact tggagttaat   3960

ggggatgcca ctggagattt tgaataggat atgttgtgat ctgaataaca tataagaaga   4020

attaatttgg taactaattt gcagattagc aaagtgattc actaacatgg tgtttctcac   4080

atttcagcca tttatgttac catttttgat ggctttttcc atattcattg ctgcctacat   4140

tgttttcttc agatctactc atttccagat ttattttgtt cttacttgac acaattctat   4200

tttgaaatca aagttttgat gtgttagtgt tttttcctaa tcacattaaa gtaactatag   4260

cagtgaatac accacacttt ggaaaaaatt gggttaggtt aatttagttt tctaggagag   4320

aataatcagg gtctgagcta gagtagtggc aggagagata gcactaaata aagacaggca   4380

ttgtgaaagg cctggccact tgatgtgagg aggaaagaca aggatgactg gtttttagag   4440

taggagaatt agccgggtgc agtggctcat gcctgtaatc cctgcacttt aggaggctga   4500

ggtgagagga tttcttgaat ccaggagttc gagaccagcc tggcaataaa gtgagaacct   4560

gtctctacaa aatataaaaa cttagccaaa catggtggtg cgtgcctgca gtcctatcta   4620

cttggagggc cgaagccaga ggatcctttg agcccaggag tctgaggctg cagcaagctg   4680

tgatcacact gctgcactcc atcctgggtg gcagaatgag acccccccca aaaaaagagt   4740

aggaaagtgg tggggttaaa gatgtaggga gatcatgttg tcctggtttg gggagctggg   4800

ggaagggaaa gaagatacgg ctgacaatct ggcaggtatc tgggtgaaaa caaaattcta   4860

gggcgtgagg cagagaggtt gacataagag agttgggaat ccatatgggg tacaggtagt   4920

ttatgccatg gaggtaaatt agaaccatga aggacaattg caaatacaaa aaaaagaggc   4980

caggcacggt ggctcacgcc tgtaatccca gcactttggg aggccgaggt gggcggatca   5040

cgaggtcagg agatcaagac catcctggct gacacgttga aaccccgtct ctactaaaaa   5100

tacaaaaaat tagctgggcg tggttgcggg cacctgtagt cccaactact tgggaggctg   5160

aggcaggaga atggcgtgaa cccgggaggc ggagcttgta gtgagctgag attgtgccac   5220

ggcattccag cctgggtgac agagcaagac tctgtctcaa aaaaaaatta aacaatgagg   5280

aaaacgttat gtaagaggag gaaccaaatg gaactgattg gagggaaaga agacggttga   5340

gtagttcttt aaaaagttcc gggttggatg ctttctagtg gtttttcaac agagaggcta   5400

agaaggaaga taactgaaaa tgggacatgc attgatactt tagtaatttg agggtacatt   5460

ttgagtgtta agaagtgaag aggaggagtc attttcaggg gcaaaagagt gtattggtag   5520

gaagattata taggcaatat aatttacttt agagcagggc tttccaacag aacttttggt   5580

aatgatgtct agtacattag ccacatgtgg cagtcaagca ctcaaaacat ggctagtgtg   5640

gctgaggggc taaaatttaa ttgtatttca ttgtagttca tttaaatttg gctacctgtg   5700

gctagtggct attatattgg acaatgcatt tctaaatatt cagatcctgg gcagaagttg   5760

gctttgacat gaagaaagac ttcttagaaa ggaaggaagt agaccgggca tggtggctca   5820

tgcctgtaat cccaacactt tgggaagccg aggcaggtgg atcacaaggt caagagatca   5880

agaccatcct ggccaacgtg gtgaaaacct gtctctacta aaaatacaaa aattagctgg   5940

acatggtggc acatgcctgt agtcccaact actcgagagg ctgaggcagg agagaaaaaa   6000

aagaaggaaa taagagggag attgggagaa aagtaaggtg ttatagctct gatctgtggt   6060

atctcctgtt ttccttgcgg tatgactagt gtgagccaag gatagagacc aacaaactgg   6120

ggtaccaaag tggacaatga agtactatgt aattagtgct aatgctaaat tcattccttt   6180

gtttaaggct taatatcctt gcagaagcca tcctgtgtta cttgagcctg gactagtatt   6240

ggggtgaagt caagcatcag agtaaaacat ttgtcccctt aatgttaccc cctcttaatt   6300

tctaagaacc acaggcccat tttgcccttc cttgttacca tcattgagat aaggaataag   6360

atgtagtaac cccaagttat ctgataggta caactgacct attctgtttg gcagctttat   6420

cttagaccta ttctgtttgg cagctttatc ttagccccaa ccaaatctct tcctttcaca   6480

tggtgttggt tgaatactat ccaactccat ggggttggtt tgtgtttttt tttttttttt   6540

tttttgagac ggagtcttgc tctgttgccc aggctggagt gcggtggtgt gatcttggct   6600

cactgcaagc tccgcctcct gggtttaagt gatcctcctg cctcagcctc ctgaatagct   6660

gggattacag gcacgtgcaa ccaagcccgg ctaatttttg tgtttttagt agagactagg   6720

tttcaacatg ttaggctgat ctcaaactcc tgacctcgtg atctgcccgc ctcggccttc   6780

caaagtgctg gggttacaga cttgagccac tgcacctggc catggggttg tttcttaatt   6840

agatatagct gaaaagaacg ctagaccaaa taggttctct gccttgcctt ttcgtttgtt   6900

ttgttttagc tattatcagg gaaccaaaaa ctttaaggag ctagtactgg tcttaatttt   6960

taataactag agatagcaga gttagaaact aagttcaaag tgagagaaca gctgcatttg   7020

tctttctgac ctcatgcaat tcctaggaaa ctctgtgttc tgtgatttag tcaggcaata   7080

aaatgctctc actcctaaaa aaaaaaaaaa aaaaaa                             7116


<210>  41
<211>  285
<212>  PRT
<213>  Homo sapiens

<400>  41


Met Met Glu Ala Ile Lys Lys Lys Met Gln Met Leu Lys Leu Asp Lys 
1               5                   10                  15      


Glu Asn Ala Leu Asp Arg Ala Glu Gln Ala Glu Ala Glu Gln Lys Gln 
            20                  25                  30          


Ala Glu Glu Arg Ser Lys Gln Leu Glu Asp Glu Leu Ala Ala Met Gln 
        35                  40                  45              


Lys Lys Leu Lys Gly Thr Glu Asp Glu Leu Asp Lys Tyr Ser Glu Ala 
    50                  55                  60                  


Leu Lys Asp Ala Gln Glu Lys Leu Glu Leu Ala Glu Lys Lys Ala Ala 
65                  70                  75                  80  


Asp Ala Glu Ala Glu Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val 
                85                  90                  95      


Glu Glu Glu Leu Asp Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln 
            100                 105                 110         


Lys Leu Glu Glu Ala Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met 
        115                 120                 125             


Lys Val Ile Glu Asn Arg Ala Leu Lys Asp Glu Glu Lys Met Glu Leu 
    130                 135                 140                 


Gln Glu Ile Gln Leu Lys Glu Ala Lys His Ile Ala Glu Glu Ala Asp 
145                 150                 155                 160 


Arg Lys Tyr Glu Glu Val Ala Arg Lys Leu Val Ile Ile Glu Gly Asp 
                165                 170                 175     


Leu Glu Arg Thr Glu Glu Arg Ala Glu Leu Ala Glu Ser Lys Cys Ser 
            180                 185                 190         


Glu Leu Glu Glu Glu Leu Lys Asn Val Thr Asn Asn Leu Lys Ser Leu 
        195                 200                 205             


Glu Ala Gln Ala Glu Lys Tyr Ser Gln Lys Glu Asp Lys Tyr Glu Glu 
    210                 215                 220                 


Glu Ile Lys Ile Leu Thr Asp Lys Leu Lys Glu Ala Glu Thr Arg Ala 
225                 230                 235                 240 


Glu Phe Ala Glu Arg Ser Val Ala Lys Leu Glu Lys Thr Ile Asp Asp 
                245                 250                 255     


Leu Glu Asp Glu Leu Tyr Ala Gln Lys Leu Lys Tyr Lys Ala Ile Ser 
            260                 265                 270         


Glu Glu Leu Asp His Ala Leu Asn Asp Met Thr Ser Ile 
        275                 280                 285 

<210>  42
<211>  3212
<212>  DNA
<213>  Homo sapiens

<400>  42
gtcacatccg ggcgggttgg tgagttccgg tatttcaggg cgtagcaggc ggaagtaagg     60

gtgagaggag gctgcaacgc cgagcggagg aggcaggaac cggagcgcga gcagtagctg    120

ggtgggcacc atggctggga tcaccaccat cgaggcggtg aagcgcaaga tccaggttct    180

gcagcagcag gcagatgatg cagaggagcg agctgagcgc ctccagcgag aagttgaggg    240

agaaaggcgg gcccgggaac aggctgaggc tgaggtggcc tccttgaacc gtaggatcca    300

gctggttgaa gaagagctgg accgtgctca ggagcgcctg gccactgccc tgcaaaagct    360

ggaagaagct gaaaaagctg ctgatgagag tgagagaggt atgaaggtta ttgaaaaccg    420

ggccttaaaa gatgaagaaa agatggaact ccaggaaatc caactcaaag aagctaagca    480

cattgcagaa gaggcagata ggaagtatga agaggtggct cgtaagttgg tgatcattga    540

aggagacttg gaacgcacag aggaacgagc tgagctggca gagtcccgtt gccgagagat    600

ggatgagcag attagactga tggaccagaa cctgaagtgt ctgagtgctg ctgaagaaaa    660

gtactctcaa aaagaagata aatatgagga agaaatcaag attcttactg ataaactcaa    720

ggaggcagag acccgtgctg agtttgctga gagatcggta gccaagctgg aaaagacaat    780

tgatgacctg gaagataaac tgaaatgcac caaagaggag cacctctgta cacaaaggat    840

gctggaccag accctgcttg acctgaatga gatgtagaac gccccagtcc caccctgctg    900

ctgctcctcc ctctgaccca gactccgcct gaggccagcc tgcgggaagc tgacctttaa    960

ctgagggctg atctttaact ggaaggctgc tttctccttt caccaccccc tccttccctg   1020

tgtctttttc gccaaactgt ctctgcctct tcccggagaa tccagctggg ctagaggctg   1080

agcacctttg gaaacaacat ttaagggaat gtgagcacaa tgcataatgt ctttaaaaag   1140

catgttgtga tgtacacatt ttgtaattac cttttttgtt gttttgtagc aaccatttgt   1200

aaaacattcc aaataattcc acagtcctga agcagcaatc gaatcccttt ctcacttttg   1260

gaaggtgact tttcacctta atgcatattc ccctctccat agaggagagg aaaaggtgta   1320

ggcctgcctt accgagagcc aaacagagcc cagggagact ccgctgtggg aaacctcatt   1380

gttctgtaca aagtactagc taaaccagaa aggtgattcc aggaggagtt agccaaacaa   1440

caacaaaaac aaaaaatgtg ctgttcaagt tttcagcttt aagatatctt tggataatgt   1500

tatttctatt ttttattttt ttcattagaa gttaccaaat taagatggta agacctctga   1560

gaccaaaatt ttgtcccatc tctaccccct cacaactgct tacagaatgg atcatgtccc   1620

ccttatgttg aggtgaccac ttaattgctt tcctgcctcc ttgaaagaaa gaaagaaaga   1680

agactgtgtt tttgccactg atttagccat gtgaaactca tctcattacc cttttctggg   1740

tttgaagctg ctgtctctag aagtgccatc tcaattgtgc tttgtatcag tcagtgctgg   1800

agaaatcttg aatagcttat gtacaaaact ttttaaattt tatattattt tgaaactttg   1860

ctttgggttt gtggcaccct ggccacccca tctggctgtg acagcctctg cagtccgtgg   1920

gctggcagtt tgttgatctt ttaagtttcc ttccctaccc agtccccatt ttctggtaag   1980

gtttctagga ggtctgttag gtgtacatcc tgcagcttat tggcttaaaa tgtactctcc   2040

ttttatgtgg tctctttggg gccgattggg agaaagagaa atcaatagtg caactgtttt   2100

gatactgaat attgacaagt gtctttttga aataaagaac cagtccctcc aaccctcaga   2160

cctatttgac ttttatttat taaaactaaa tgtgctttct ccacagaagc tatgaggttt   2220

gggttaaaaa tagcatcttt gtgggtggta gcaacaggat ttattcttta ttattattat   2280

ttttgagatg aagtttcatt cttgttgcct gggctggagc gtaatggctc gatctcggct   2340

cactgcaacc tccgcctcct ggttcaagag attctcctgc ctcagcctcc cgagtagctg   2400

ggattacagg cacctgccac catgcccggg taatttttta tattttaagt agagacaggg   2460

cttcaccatg ttggccaggc tggtctcgaa ctcctgacct tcaggtgatc cacctgcctc   2520

agcttcccaa aatgctggga ttacgggcgt gagccaccgc acccagctgg agcaacagga   2580

tttaatatag agcaaatgtt tagttttatc atctgtaaaa tggagataag tattgtcaga   2640

gtaaacatga agattagaaa gaacacttaa tgtgctgggc cttttatagg ttaacactga   2700

catctcaggc tgaactatat acattttcct tcacaaccat atcaatcctt ataaactatg   2760

gatttatgct ccttaaaaca atatataatg ctgatcacta ctataaatgc gtggttttaa   2820

ccaactgtac tgaaacagct ttgagtttat attctgtttg gatatttgga gaaaacaaca   2880

agtgctctca agagtatttg cttagaggcc ggctgtgtga gtggataact ttgaaagctg   2940

cttttgagac gccagtgtct ggcatttcct gcattctggc ctggaggccg gacgtgaatc   3000

tgacttctag taaaaataca cggttccctt gacaaagtcg agctgtttat cccagagact   3060

gcacaatttt ccgttgatag gcatggacca atgctaactg gaaatcattg caaaaagttt   3120

ttttgtcggg cggagggtgt ggtgttaaga taaacagtgt gcaacagaag aaattaaaac   3180

tggaagaaat taaagggttt tttttagact tt                                 3212


<210>  43
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  43


Met Ala Gly Ile Thr Thr Ile Glu Ala Val Lys Arg Lys Ile Gln Val 
1               5                   10                  15      


Leu Gln Gln Gln Ala Asp Asp Ala Glu Glu Arg Ala Glu Arg Leu Gln 
            20                  25                  30          


Arg Glu Val Glu Gly Glu Arg Arg Ala Arg Glu Gln Ala Glu Ala Glu 
        35                  40                  45              


Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu Glu Glu Leu Asp 
    50                  55                  60                  


Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys Leu Glu Glu Ala 
65                  70                  75                  80  


Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys Val Ile Glu Asn 
                85                  90                  95      


Arg Ala Leu Lys Asp Glu Glu Lys Met Glu Leu Gln Glu Ile Gln Leu 
            100                 105                 110         


Lys Glu Ala Lys His Ile Ala Glu Glu Ala Asp Arg Lys Tyr Glu Glu 
        115                 120                 125             


Val Ala Arg Lys Leu Val Ile Ile Glu Gly Asp Leu Glu Arg Thr Glu 
    130                 135                 140                 


Glu Arg Ala Glu Leu Ala Glu Ser Arg Cys Arg Glu Met Asp Glu Gln 
145                 150                 155                 160 


Ile Arg Leu Met Asp Gln Asn Leu Lys Cys Leu Ser Ala Ala Glu Glu 
                165                 170                 175     


Lys Tyr Ser Gln Lys Glu Asp Lys Tyr Glu Glu Glu Ile Lys Ile Leu 
            180                 185                 190         


Thr Asp Lys Leu Lys Glu Ala Glu Thr Arg Ala Glu Phe Ala Glu Arg 
        195                 200                 205             


Ser Val Ala Lys Leu Glu Lys Thr Ile Asp Asp Leu Glu Asp Lys Leu 
    210                 215                 220                 


Lys Cys Thr Lys Glu Glu His Leu Cys Thr Gln Arg Met Leu Asp Gln 
225                 230                 235                 240 


Thr Leu Leu Asp Leu Asn Glu Met 
                245             

<210>  44
<211>  387
<212>  DNA
<213>  Homo sapiens

<400>  44
agactgtatc aagcaaatct atagacatgt ctgtggaaaa gatgacaaaa gtagaagaga     60

gttttcaaaa ggccatggga cttaagaaga cggtcgacag gtggcgaaat tcacatactc    120

actgtctgtg gcaaatggca ttgggccaga gaagaaaccc gtatgccacc ctaaggatgc    180

aggacaccat ggtacaggaa ttggcactgg ccaaaaagca actactaatg gtccgtcaag    240

ctgccctgca ccagctgttt gaaaaggagc atcagcagta ccagcaggaa ctaaatcaga    300

tgggcaaagc tttttatgta gagagattct gatggcatcc aaaacactgc tcttccattc    360

tcaacatgcc tgctaaccta gccttct                                        387


<210>  45
<211>  101
<212>  PRT
<213>  Homo sapiens

<400>  45


Met Ser Val Glu Lys Met Thr Lys Val Glu Glu Ser Phe Gln Lys Ala 
1               5                   10                  15      


Met Gly Leu Lys Lys Thr Val Asp Arg Trp Arg Asn Ser His Thr His 
            20                  25                  30          


Cys Leu Trp Gln Met Ala Leu Gly Gln Arg Arg Asn Pro Tyr Ala Thr 
        35                  40                  45              


Leu Arg Met Gln Asp Thr Met Val Gln Glu Leu Ala Leu Ala Lys Lys 
    50                  55                  60                  


Gln Leu Leu Met Val Arg Gln Ala Ala Leu His Gln Leu Phe Glu Lys 
65                  70                  75                  80  


Glu His Gln Gln Tyr Gln Gln Glu Leu Asn Gln Met Gly Lys Ala Phe 
                85                  90                  95      


Tyr Val Glu Arg Phe 
            100     

<210>  46
<211>  1909
<212>  DNA
<213>  Homo sapiens

<400>  46
gtgcgcgtgc cgcctcgcca cgagacacct ctttccggct ccgcgagtcc accccgcctc     60

cttcacggcg gccctgcctc caccacgtga cgcacggatg gccgccgctt cctcttactg    120

tcgtagttcc gcgtctgagc gctcgacgct cctgggtgcc attgcctgcc tgagtcacgt    180

gtcaggggga agctggaagg cgtcgttctc ctttcccagc tctcctgcct gtccgccatg    240

ttttcaggcc gggtctggct tggtcttccc ccgtaaggaa atggccgggg agctccaggg    300

gacccaggcg ccgtcgcttc ggcggagcct gggctgacca gccaggacag cggggtaaac    360

ccgaacaatt ctgcgcgagg tagggaggcc atggcgtccg gcagtaactg gctctccggg    420

gtgaatgtcg tgctggtgat ggcctacggg agcctggtgt ttgtactgct atttattttt    480

gtgaagaggc aaatcatgcg ctttgcaatg aaatctcgaa ggggacctca tgtccctgtg    540

ggacacaatg cccccaagga cttgaaagag gagattgata ttcgactctc cagggttcag    600

gatatcaagt atgagcccca gctccttgca gatgatgatg ctagactact acaactggaa    660

acccagggaa atcaaagttg ctacaactat ctgtatagga tgaaagctct ggatgccatt    720

cgtacctctg agatcccatt tcattctgaa ggccggcatc cccgttcctt aatgggcaag    780

aatttccgct cctacctgct ggatctgcga aacactagta cgcctttcaa gggtgtacgc    840

aaagcactca ttgataccct tttggatggc tatgaaacag cccgctatgg gacaggggtc    900

tttggccaga atgagtacct acgctatcag gaggccctga gtgagctggc cactgcggtt    960

aaagcacgaa ttgggagctc tcagcgacat caccagtcag cagccaaaga cctaactcag   1020

tcccctgagg tctccccaac aaccatccag gtgacatacc tcccctccag tcagaagagt   1080

aaacgtgcca agcacttcct tgaattgaag agctttaagg ataactataa cacattggag   1140

agtactctgt gacggagctg aaggactctt gccgtagatt aagccagtca gttgcaatgt   1200

gcaagacagg ctgcttgccg ggccgccctc ggaacatctg gcccagcagg cccagactgt   1260

atccatccaa gttcccgttg tatccagagt tcttagagct tgtgtctaaa gggtaattcc   1320

ccaacccttc cttatgagca tttttagaac attggctaag actattttcc cccagtagcg   1380

cttttttctg gatttgcatt caggtgttat tcttaatgtt tctgtcaaag cttcttaaaa   1440

atcttcactt ggtttcagcc atagttcacc ttccctgttc caggtttatt taattccaaa   1500

ggtgagagtt ggagtgagat gtcttccata tctatacctt tgtgcacagt tgaatgggaa   1560

ctgtttgggt ttagggcatc ttagagttga ttgatggaaa aagcagacag gaactggtgg   1620

gaggtcaagt ggggaagttg gtgaatgtgg aataacttac ctttgtgctc cacttaaacc   1680

agatgtgttg cagctttcct gacatgcaag gatctacttt aattccacac tctcattaat   1740

aaattgaata aaagggaatg ttttggcacc tgatataatc tgccaggcta tgtgacagta   1800

ggaaggaatg gtttccccta acaagcccaa tgcactggtc tgactttata aattatttaa   1860

taaaatgaac tattatcaaa taaaacgtat gaatcagtaa aaaaaaaaa               1909


<210>  47
<211>  253
<212>  PRT
<213>  Homo sapiens

<400>  47


Met Ala Ser Gly Ser Asn Trp Leu Ser Gly Val Asn Val Val Leu Val 
1               5                   10                  15      


Met Ala Tyr Gly Ser Leu Val Phe Val Leu Leu Phe Ile Phe Val Lys 
            20                  25                  30          


Arg Gln Ile Met Arg Phe Ala Met Lys Ser Arg Arg Gly Pro His Val 
        35                  40                  45              


Pro Val Gly His Asn Ala Pro Lys Asp Leu Lys Glu Glu Ile Asp Ile 
    50                  55                  60                  


Arg Leu Ser Arg Val Gln Asp Ile Lys Tyr Glu Pro Gln Leu Leu Ala 
65                  70                  75                  80  


Asp Asp Asp Ala Arg Leu Leu Gln Leu Glu Thr Gln Gly Asn Gln Ser 
                85                  90                  95      


Cys Tyr Asn Tyr Leu Tyr Arg Met Lys Ala Leu Asp Ala Ile Arg Thr 
            100                 105                 110         


Ser Glu Ile Pro Phe His Ser Glu Gly Arg His Pro Arg Ser Leu Met 
        115                 120                 125             


Gly Lys Asn Phe Arg Ser Tyr Leu Leu Asp Leu Arg Asn Thr Ser Thr 
    130                 135                 140                 


Pro Phe Lys Gly Val Arg Lys Ala Leu Ile Asp Thr Leu Leu Asp Gly 
145                 150                 155                 160 


Tyr Glu Thr Ala Arg Tyr Gly Thr Gly Val Phe Gly Gln Asn Glu Tyr 
                165                 170                 175     


Leu Arg Tyr Gln Glu Ala Leu Ser Glu Leu Ala Thr Ala Val Lys Ala 
            180                 185                 190         


Arg Ile Gly Ser Ser Gln Arg His His Gln Ser Ala Ala Lys Asp Leu 
        195                 200                 205             


Thr Gln Ser Pro Glu Val Ser Pro Thr Thr Ile Gln Val Thr Tyr Leu 
    210                 215                 220                 


Pro Ser Ser Gln Lys Ser Lys Arg Ala Lys His Phe Leu Glu Leu Lys 
225                 230                 235                 240 


Ser Phe Lys Asp Asn Tyr Asn Thr Leu Glu Ser Thr Leu 
                245                 250             

<210>  48
<211>  1807
<212>  DNA
<213>  Homo sapiens

<400>  48
gtgcgcgtgc cgcctcgcca cgagacacct ctttccggct ccgcgagtcc accccgcctc     60

cttcacggcg gccctgcctc caccacgtga cgcacggatg gccgccgctt cctcttactg    120

tcgtagttcc gcgtctgagc gctcgacgct cctgggtgcc attgcctgcc tgagtcacgt    180

gtcaggggga agctggaagg cgtcgttctc ctttcccagc tctcctgcct gtccgccatg    240

ttttcaggcc gggtctggct tggtcttccc ccgtaaggaa atggccgggg agctccaggg    300

gacccaggcg ccgtcgcttc ggcggagcct gggctgacca gccaggacag cggggtaaac    360

ccgaacaatt ctgcgcgagg tagggaggcc atggcgtccg gcagtaactg gctctccggg    420

gtgaatgtcg tgctggtgat ggcctacggg agcctggact tgaaagagga gattgatatt    480

cgactctcca gggttcagga tatcaagtat gagccccagc tccttgcaga tgatgatgct    540

agactactac aactggaaac ccagggaaat caaagttgct acaactatct gtataggatg    600

aaagctctgg atgccattcg tacctctgag atcccatttc attctgaagg ccggcatccc    660

cgttccttaa tgggcaagaa tttccgctcc tacctgctgg atctgcgaaa cactagtacg    720

cctttcaagg gtgtacgcaa agcactcatt gatacccttt tggatggcta tgaaacagcc    780

cgctatggga caggggtctt tggccagaat gagtacctac gctatcagga ggccctgagt    840

gagctggcca ctgcggttaa agcacgaatt gggagctctc agcgacatca ccagtcagca    900

gccaaagacc taactcagtc ccctgaggtc tccccaacaa ccatccaggt gacatacctc    960

ccctccagtc agaagagtaa acgtgccaag cacttccttg aattgaagag ctttaaggat   1020

aactataaca cattggagag tactctgtga cggagctgaa ggactcttgc cgtagattaa   1080

gccagtcagt tgcaatgtgc aagacaggct gcttgccggg ccgccctcgg aacatctggc   1140

ccagcaggcc cagactgtat ccatccaagt tcccgttgta tccagagttc ttagagcttg   1200

tgtctaaagg gtaattcccc aacccttcct tatgagcatt tttagaacat tggctaagac   1260

tattttcccc cagtagcgct tttttctgga tttgcattca ggtgttattc ttaatgtttc   1320

tgtcaaagct tcttaaaaat cttcacttgg tttcagccat agttcacctt ccctgttcca   1380

ggtttattta attccaaagg tgagagttgg agtgagatgt cttccatatc tatacctttg   1440

tgcacagttg aatgggaact gtttgggttt agggcatctt agagttgatt gatggaaaaa   1500

gcagacagga actggtggga ggtcaagtgg ggaagttggt gaatgtggaa taacttacct   1560

ttgtgctcca cttaaaccag atgtgttgca gctttcctga catgcaagga tctactttaa   1620

ttccacactc tcattaataa attgaataaa agggaatgtt ttggcacctg atataatctg   1680

ccaggctatg tgacagtagg aaggaatggt ttcccctaac aagcccaatg cactggtctg   1740

actttataaa ttatttaata aaatgaacta ttatcaaata aaacgtatga atcagtaaaa   1800

aaaaaaa                                                             1807


<210>  49
<211>  219
<212>  PRT
<213>  Homo sapiens

<400>  49


Met Ala Ser Gly Ser Asn Trp Leu Ser Gly Val Asn Val Val Leu Val 
1               5                   10                  15      


Met Ala Tyr Gly Ser Leu Asp Leu Lys Glu Glu Ile Asp Ile Arg Leu 
            20                  25                  30          


Ser Arg Val Gln Asp Ile Lys Tyr Glu Pro Gln Leu Leu Ala Asp Asp 
        35                  40                  45              


Asp Ala Arg Leu Leu Gln Leu Glu Thr Gln Gly Asn Gln Ser Cys Tyr 
    50                  55                  60                  


Asn Tyr Leu Tyr Arg Met Lys Ala Leu Asp Ala Ile Arg Thr Ser Glu 
65                  70                  75                  80  


Ile Pro Phe His Ser Glu Gly Arg His Pro Arg Ser Leu Met Gly Lys 
                85                  90                  95      


Asn Phe Arg Ser Tyr Leu Leu Asp Leu Arg Asn Thr Ser Thr Pro Phe 
            100                 105                 110         


Lys Gly Val Arg Lys Ala Leu Ile Asp Thr Leu Leu Asp Gly Tyr Glu 
        115                 120                 125             


Thr Ala Arg Tyr Gly Thr Gly Val Phe Gly Gln Asn Glu Tyr Leu Arg 
    130                 135                 140                 


Tyr Gln Glu Ala Leu Ser Glu Leu Ala Thr Ala Val Lys Ala Arg Ile 
145                 150                 155                 160 


Gly Ser Ser Gln Arg His His Gln Ser Ala Ala Lys Asp Leu Thr Gln 
                165                 170                 175     


Ser Pro Glu Val Ser Pro Thr Thr Ile Gln Val Thr Tyr Leu Pro Ser 
            180                 185                 190         


Ser Gln Lys Ser Lys Arg Ala Lys His Phe Leu Glu Leu Lys Ser Phe 
        195                 200                 205             


Lys Asp Asn Tyr Asn Thr Leu Glu Ser Thr Leu 
    210                 215                 

<210>  50
<211>  1753
<212>  DNA
<213>  Homo sapiens

<400>  50
gtgcgcgtgc cgcctcgcca cgagacacct ctttccggct ccgcgagtcc accccgcctc     60

cttcacggcg gccctgcctc caccacgtga cgcacggatg gccgccgctt cctcttactg    120

tcgtagttcc gcgtctgagc gctcgacgct cctgggtgcc attgcctgcc tgagtcacgt    180

gtcaggggga agctggaagg cgtcgttctc ctttcccagc tctcctgcct gtccgccatg    240

ttttcaggcc gggtctggct tggtcttccc ccgtaaggaa atggccgggg agctccaggg    300

gacccaggcg ccgtcgcttc ggcggagcct gggctgacca gccaggacag cggggtaaac    360

ccgaacaatt ctgcgcgagg tagggaggcc atggcgtccg gcagtaactg gctctccggg    420

gtgaatgtcg tgctggtgat ggcctacggg agcctggact tgaaagagga gattgatatt    480

cgactctcca gggttcagga tatcaagtat gagccccagc tccttgcaga tgatgatgct    540

agactactac aactggaaac ccagggaaat caaaagatcc catttcattc tgaaggccgg    600

catccccgtt ccttaatggg caagaatttc cgctcctacc tgctggatct gcgaaacact    660

agtacgcctt tcaagggtgt acgcaaagca ctcattgata cccttttgga tggctatgaa    720

acagcccgct atgggacagg ggtctttggc cagaatgagt acctacgcta tcaggaggcc    780

ctgagtgagc tggccactgc ggttaaagca cgaattggga gctctcagcg acatcaccag    840

tcagcagcca aagacctaac tcagtcccct gaggtctccc caacaaccat ccaggtgaca    900

tacctcccct ccagtcagaa gagtaaacgt gccaagcact tccttgaatt gaagagcttt    960

aaggataact ataacacatt ggagagtact ctgtgacgga gctgaaggac tcttgccgta   1020

gattaagcca gtcagttgca atgtgcaaga caggctgctt gccgggccgc cctcggaaca   1080

tctggcccag caggcccaga ctgtatccat ccaagttccc gttgtatcca gagttcttag   1140

agcttgtgtc taaagggtaa ttccccaacc cttccttatg agcattttta gaacattggc   1200

taagactatt ttcccccagt agcgcttttt tctggatttg cattcaggtg ttattcttaa   1260

tgtttctgtc aaagcttctt aaaaatcttc acttggtttc agccatagtt caccttccct   1320

gttccaggtt tatttaattc caaaggtgag agttggagtg agatgtcttc catatctata   1380

cctttgtgca cagttgaatg ggaactgttt gggtttaggg catcttagag ttgattgatg   1440

gaaaaagcag acaggaactg gtgggaggtc aagtggggaa gttggtgaat gtggaataac   1500

ttacctttgt gctccactta aaccagatgt gttgcagctt tcctgacatg caaggatcta   1560

ctttaattcc acactctcat taataaattg aataaaaggg aatgttttgg cacctgatat   1620

aatctgccag gctatgtgac agtaggaagg aatggtttcc cctaacaagc ccaatgcact   1680

ggtctgactt tataaattat ttaataaaat gaactattat caaataaaac gtatgaatca   1740

gtaaaaaaaa aaa                                                      1753


<210>  51
<211>  201
<212>  PRT
<213>  Homo sapiens

<400>  51


Met Ala Ser Gly Ser Asn Trp Leu Ser Gly Val Asn Val Val Leu Val 
1               5                   10                  15      


Met Ala Tyr Gly Ser Leu Asp Leu Lys Glu Glu Ile Asp Ile Arg Leu 
            20                  25                  30          


Ser Arg Val Gln Asp Ile Lys Tyr Glu Pro Gln Leu Leu Ala Asp Asp 
        35                  40                  45              


Asp Ala Arg Leu Leu Gln Leu Glu Thr Gln Gly Asn Gln Lys Ile Pro 
    50                  55                  60                  


Phe His Ser Glu Gly Arg His Pro Arg Ser Leu Met Gly Lys Asn Phe 
65                  70                  75                  80  


Arg Ser Tyr Leu Leu Asp Leu Arg Asn Thr Ser Thr Pro Phe Lys Gly 
                85                  90                  95      


Val Arg Lys Ala Leu Ile Asp Thr Leu Leu Asp Gly Tyr Glu Thr Ala 
            100                 105                 110         


Arg Tyr Gly Thr Gly Val Phe Gly Gln Asn Glu Tyr Leu Arg Tyr Gln 
        115                 120                 125             


Glu Ala Leu Ser Glu Leu Ala Thr Ala Val Lys Ala Arg Ile Gly Ser 
    130                 135                 140                 


Ser Gln Arg His His Gln Ser Ala Ala Lys Asp Leu Thr Gln Ser Pro 
145                 150                 155                 160 


Glu Val Ser Pro Thr Thr Ile Gln Val Thr Tyr Leu Pro Ser Ser Gln 
                165                 170                 175     


Lys Ser Lys Arg Ala Lys His Phe Leu Glu Leu Lys Ser Phe Lys Asp 
            180                 185                 190         


Asn Tyr Asn Thr Leu Glu Ser Thr Leu 
        195                 200     

<210>  52
<211>  4006
<212>  DNA
<213>  Homo sapiens

<400>  52
aagtgggcgg gggaaggcgc gagagcgagc gcgagaggga aaaggaggga gggggtgggg     60

aagagggaat cttatatcac gtgacagggg cggcgcggcc cggggtgtca gtgtggagga    120

gactgagtat tctaccttgt aaatactgtt atttgtatat actgtaaatg atgacatcgg    180

tgggcactaa ccgagcccgg ggaaactggg aacaacctca aaaccaaaac cagacacagc    240

acaagcagcg gccacaggcc actgcagaac aaattagact tgcacagatg atttcggacc    300

ataatgatgc tgactttgag gagaaggtga aacaattgat tgatattaca ggcaagaacc    360

aggatgaatg tgtgattgct ttgcatgact gcaatggaga tgtcaacaga gctatcaatg    420

ttcttctgga aggaaaccca gacacgcatt cctgggagat ggtcgggaag aagaagggag    480

tctcaggcca gaaggatggt ggccagacgg aatccaatga ggaaggcaaa gaaaatcgag    540

accgggacag agactatagt cggcgacgtg gtgggccacc aagacggggg agaggtgcca    600

gccgtggacg agagtttcga ggtcaggaaa atggattgga tggcaccaag agtggagggc    660

cttctggaag aggaacagaa agaggcagaa ggggccgtgg ccgaggcaga ggtggctctg    720

gtaggcgagg aggaaggttt tctgctcaag gaatgggaac ctttaaccca gctgattatg    780

cagagccagc caatactgat gataactatg gcaatagcag cggcaatacg tggaacaaca    840

ctggccactt tgaaccagat gatgggacga gtgcatggag gactgcaaca gaggagtggg    900

ggactgaaga ttggaatgaa gatctttctg agaccaagat cttcactgcc tctaatgtgt    960

cttcagtgcc tctgcctgcg gagaatgtga caatcactgc tggtcagaga attgaccttg   1020

ctgttctgct ggggaagaca ccatctacaa tggagaatga ttcatctaat ctggatccgt   1080

ctcaggctcc ttctctggcc cagcctctgg tgttcagtaa ttcgaagcag actgccatat   1140

cacagcctgc ttcagggaac acattttctc atcacagtat ggtgagcatg ttagggaaag   1200

gatttggtga tgtcggtgaa gctaaaggcg gcagtactac aggctcccag ttcttggagc   1260

aattcaagac tgcccaagcc ctggctcagt tggcagctca gcattctcag tctggaagca   1320

ccaccacctc ctcttgggac atgggctcga cgacacaatc cccatcactg gtgcagtatg   1380

atttgaagaa cccaagtgat tcagcagtgc acagcccctt tacaaagcgc caggctttta   1440

ccccatcttc aaccatgatg gaggtgttcc ttcaggagaa gtcacctgca gtggctacct   1500

ccacagctgc acctccacct ccgtcttctc ctctgccaag caaatccaca tcggctccac   1560

agatgtcgcc tggatcttca gacaaccagt cctctagccc tcagccggct cagcagaaac   1620

tgaaacagca gaagaaaaaa gcctccttga cttctaagat tcctgctctg gctgtggaga   1680

tgcctggctc agcagatatc tcagggctaa acctgcagtt tggggcattg cagtttgggt   1740

cagagcctgt cctttctgat tatgagtcca cccccaccac gagcgcctct tcaagccagg   1800

ctccaagtag cctgtatacc agcacggcca gtgaatcatc ctctacaatt tcatctaacc   1860

agagtcagga gtctggttat cagagcggcc caattcagtc gacaacctat acctcccaaa   1920

ataatgctca gggccctctt tatgaacaga gatccacaca gactcggcgg taccccagct   1980

ccatctcttc atcaccccaa aaggacctga ctcaggcaaa gaatggcttc agttctgtgc   2040

aggccacgca gttacagacc acacaatctg ttgaaggtgc tacaggctct gcagtgaaat   2100

ctgattcacc ttccacttct agcatccccc ctctcaatga aacggtatct gcagcttcct   2160

tactgacgac aaccaatcag cattcatcct ccttgggtgg cttgagccac agtgaggaga   2220

ttccaaatac taccaccaca caacacagca gcacgttatc tacgcagcag aatacccttt   2280

catcatcaac atcttctggg cgcacttcga catccactct tttgcacaca agtgtggaga   2340

gtgaggcgaa tctccattct tcctccagca ctttttccac cacatccagc acagtctctg   2400

cacctccccc agtggtcagt gtctcctcca gtctcaatag tggcagtagc ctgggcctca   2460

gcctaggcag caactccact gtcacagcct cgactcgaag ctcagttgct acgacttcag   2520

gaaaagctcc tcccaacctc cctcctgggg tcccgccgtt gttgcctaat ccgtatatta   2580

tggctccagg gctgttacat gcctacccgc cacaagtata tggttatgat gacttgcaga   2640

tgcttcagac aagatttcca ttggattact acagcatccc atttcccaca cccactactc   2700

cgctgactgg gagggatggt agcctggcca gcaaccctta ttctggtgac ctcacaaagt   2760

tcggccgtgg ggatgcctcc tccccagccc cggccacaac cttggcccaa ccccaacaga   2820

accagacgca gactcaccat accacgcagc agacattcct gaacccggcg ctgcctcctg   2880

gctacagtta caccagcctg ccatactata caggggtccc gggcctcccc agcaccttcc   2940

agtatgggcc tgctgtgttc cctgtggctc ctacctcttc caagcagcat ggtgtgaatg   3000

tcagtgtgaa tgcatcggcc acccctttcc aacagccgag tggatatggg tctcatggat   3060

acaacactgg tgtttcagtc acctccagta acacgggcgt gccagatatc tcgggttctg   3120

tgtactccaa aacccagcag tcctttgaga aacaaggttt tcattccggt actcctgctg   3180

cttccttcaa cttgccttca gccctaggaa gtgggggccc catcaatccg gccacagctg   3240

ctgcctaccc acctgccccc tttatgcaca ttctgacccc ccatcagcag ccgcattctc   3300

agatccttca ccatcacctg cagcaggatg gccagacggg cagcgggcaa cgtagccaga   3360

ccagctccat cccgcagaag ccccagacca acaagtctgc ctacaacagc tacagctggg   3420

gggccaactg aggccctgac cctcttctcc cggtcccatc ttctgagagg gcttctcagc   3480

ctggaaacta tggaaacagc atcaaagaga aaggaatgtg gggggtttcc gctgcccccc   3540

acccccagcg gcccacccca tgcctcagct tcatgtctgt cccattccta taccatcccc   3600

accctgttgt atgtattata ggatttgtat tttctccttt tttttccccc ttccattcct   3660

tctcccctct tgcattcaag attatgaaac tttgctatgg gccctgcact tcctttgctt   3720

cctcctgttc accctggtgg tgtacggatg aggcggggag gtgggacccc caaacatata   3780

tcagcccaac agccctaagt ctccttcttt attattagga aaacaacaac aacaacaaac   3840

aaaaaaatgg cgtcatgaat atgaacagca ttgtcagatg aattagttga agtggttttt   3900

tttttgtttt tttttttttt ttgtactgtg tcctcaaatt taatggatta atgtgtcttg   3960

tatatataaa aagaaaacct ctaccttcaa aaaaaaaaaa aaaaaa                  4006


<210>  53
<211>  1087
<212>  PRT
<213>  Homo sapiens

<400>  53


Met Met Thr Ser Val Gly Thr Asn Arg Ala Arg Gly Asn Trp Glu Gln 
1               5                   10                  15      


Pro Gln Asn Gln Asn Gln Thr Gln His Lys Gln Arg Pro Gln Ala Thr 
            20                  25                  30          


Ala Glu Gln Ile Arg Leu Ala Gln Met Ile Ser Asp His Asn Asp Ala 
        35                  40                  45              


Asp Phe Glu Glu Lys Val Lys Gln Leu Ile Asp Ile Thr Gly Lys Asn 
    50                  55                  60                  


Gln Asp Glu Cys Val Ile Ala Leu His Asp Cys Asn Gly Asp Val Asn 
65                  70                  75                  80  


Arg Ala Ile Asn Val Leu Leu Glu Gly Asn Pro Asp Thr His Ser Trp 
                85                  90                  95      


Glu Met Val Gly Lys Lys Lys Gly Val Ser Gly Gln Lys Asp Gly Gly 
            100                 105                 110         


Gln Thr Glu Ser Asn Glu Glu Gly Lys Glu Asn Arg Asp Arg Asp Arg 
        115                 120                 125             


Asp Tyr Ser Arg Arg Arg Gly Gly Pro Pro Arg Arg Gly Arg Gly Ala 
    130                 135                 140                 


Ser Arg Gly Arg Glu Phe Arg Gly Gln Glu Asn Gly Leu Asp Gly Thr 
145                 150                 155                 160 


Lys Ser Gly Gly Pro Ser Gly Arg Gly Thr Glu Arg Gly Arg Arg Gly 
                165                 170                 175     


Arg Gly Arg Gly Arg Gly Gly Ser Gly Arg Arg Gly Gly Arg Phe Ser 
            180                 185                 190         


Ala Gln Gly Met Gly Thr Phe Asn Pro Ala Asp Tyr Ala Glu Pro Ala 
        195                 200                 205             


Asn Thr Asp Asp Asn Tyr Gly Asn Ser Ser Gly Asn Thr Trp Asn Asn 
    210                 215                 220                 


Thr Gly His Phe Glu Pro Asp Asp Gly Thr Ser Ala Trp Arg Thr Ala 
225                 230                 235                 240 


Thr Glu Glu Trp Gly Thr Glu Asp Trp Asn Glu Asp Leu Ser Glu Thr 
                245                 250                 255     


Lys Ile Phe Thr Ala Ser Asn Val Ser Ser Val Pro Leu Pro Ala Glu 
            260                 265                 270         


Asn Val Thr Ile Thr Ala Gly Gln Arg Ile Asp Leu Ala Val Leu Leu 
        275                 280                 285             


Gly Lys Thr Pro Ser Thr Met Glu Asn Asp Ser Ser Asn Leu Asp Pro 
    290                 295                 300                 


Ser Gln Ala Pro Ser Leu Ala Gln Pro Leu Val Phe Ser Asn Ser Lys 
305                 310                 315                 320 


Gln Thr Ala Ile Ser Gln Pro Ala Ser Gly Asn Thr Phe Ser His His 
                325                 330                 335     


Ser Met Val Ser Met Leu Gly Lys Gly Phe Gly Asp Val Gly Glu Ala 
            340                 345                 350         


Lys Gly Gly Ser Thr Thr Gly Ser Gln Phe Leu Glu Gln Phe Lys Thr 
        355                 360                 365             


Ala Gln Ala Leu Ala Gln Leu Ala Ala Gln His Ser Gln Ser Gly Ser 
    370                 375                 380                 


Thr Thr Thr Ser Ser Trp Asp Met Gly Ser Thr Thr Gln Ser Pro Ser 
385                 390                 395                 400 


Leu Val Gln Tyr Asp Leu Lys Asn Pro Ser Asp Ser Ala Val His Ser 
                405                 410                 415     


Pro Phe Thr Lys Arg Gln Ala Phe Thr Pro Ser Ser Thr Met Met Glu 
            420                 425                 430         


Val Phe Leu Gln Glu Lys Ser Pro Ala Val Ala Thr Ser Thr Ala Ala 
        435                 440                 445             


Pro Pro Pro Pro Ser Ser Pro Leu Pro Ser Lys Ser Thr Ser Ala Pro 
    450                 455                 460                 


Gln Met Ser Pro Gly Ser Ser Asp Asn Gln Ser Ser Ser Pro Gln Pro 
465                 470                 475                 480 


Ala Gln Gln Lys Leu Lys Gln Gln Lys Lys Lys Ala Ser Leu Thr Ser 
                485                 490                 495     


Lys Ile Pro Ala Leu Ala Val Glu Met Pro Gly Ser Ala Asp Ile Ser 
            500                 505                 510         


Gly Leu Asn Leu Gln Phe Gly Ala Leu Gln Phe Gly Ser Glu Pro Val 
        515                 520                 525             


Leu Ser Asp Tyr Glu Ser Thr Pro Thr Thr Ser Ala Ser Ser Ser Gln 
    530                 535                 540                 


Ala Pro Ser Ser Leu Tyr Thr Ser Thr Ala Ser Glu Ser Ser Ser Thr 
545                 550                 555                 560 


Ile Ser Ser Asn Gln Ser Gln Glu Ser Gly Tyr Gln Ser Gly Pro Ile 
                565                 570                 575     


Gln Ser Thr Thr Tyr Thr Ser Gln Asn Asn Ala Gln Gly Pro Leu Tyr 
            580                 585                 590         


Glu Gln Arg Ser Thr Gln Thr Arg Arg Tyr Pro Ser Ser Ile Ser Ser 
        595                 600                 605             


Ser Pro Gln Lys Asp Leu Thr Gln Ala Lys Asn Gly Phe Ser Ser Val 
    610                 615                 620                 


Gln Ala Thr Gln Leu Gln Thr Thr Gln Ser Val Glu Gly Ala Thr Gly 
625                 630                 635                 640 


Ser Ala Val Lys Ser Asp Ser Pro Ser Thr Ser Ser Ile Pro Pro Leu 
                645                 650                 655     


Asn Glu Thr Val Ser Ala Ala Ser Leu Leu Thr Thr Thr Asn Gln His 
            660                 665                 670         


Ser Ser Ser Leu Gly Gly Leu Ser His Ser Glu Glu Ile Pro Asn Thr 
        675                 680                 685             


Thr Thr Thr Gln His Ser Ser Thr Leu Ser Thr Gln Gln Asn Thr Leu 
    690                 695                 700                 


Ser Ser Ser Thr Ser Ser Gly Arg Thr Ser Thr Ser Thr Leu Leu His 
705                 710                 715                 720 


Thr Ser Val Glu Ser Glu Ala Asn Leu His Ser Ser Ser Ser Thr Phe 
                725                 730                 735     


Ser Thr Thr Ser Ser Thr Val Ser Ala Pro Pro Pro Val Val Ser Val 
            740                 745                 750         


Ser Ser Ser Leu Asn Ser Gly Ser Ser Leu Gly Leu Ser Leu Gly Ser 
        755                 760                 765             


Asn Ser Thr Val Thr Ala Ser Thr Arg Ser Ser Val Ala Thr Thr Ser 
    770                 775                 780                 


Gly Lys Ala Pro Pro Asn Leu Pro Pro Gly Val Pro Pro Leu Leu Pro 
785                 790                 795                 800 


Asn Pro Tyr Ile Met Ala Pro Gly Leu Leu His Ala Tyr Pro Pro Gln 
                805                 810                 815     


Val Tyr Gly Tyr Asp Asp Leu Gln Met Leu Gln Thr Arg Phe Pro Leu 
            820                 825                 830         


Asp Tyr Tyr Ser Ile Pro Phe Pro Thr Pro Thr Thr Pro Leu Thr Gly 
        835                 840                 845             


Arg Asp Gly Ser Leu Ala Ser Asn Pro Tyr Ser Gly Asp Leu Thr Lys 
    850                 855                 860                 


Phe Gly Arg Gly Asp Ala Ser Ser Pro Ala Pro Ala Thr Thr Leu Ala 
865                 870                 875                 880 


Gln Pro Gln Gln Asn Gln Thr Gln Thr His His Thr Thr Gln Gln Thr 
                885                 890                 895     


Phe Leu Asn Pro Ala Leu Pro Pro Gly Tyr Ser Tyr Thr Ser Leu Pro 
            900                 905                 910         


Tyr Tyr Thr Gly Val Pro Gly Leu Pro Ser Thr Phe Gln Tyr Gly Pro 
        915                 920                 925             


Ala Val Phe Pro Val Ala Pro Thr Ser Ser Lys Gln His Gly Val Asn 
    930                 935                 940                 


Val Ser Val Asn Ala Ser Ala Thr Pro Phe Gln Gln Pro Ser Gly Tyr 
945                 950                 955                 960 


Gly Ser His Gly Tyr Asn Thr Gly Val Ser Val Thr Ser Ser Asn Thr 
                965                 970                 975     


Gly Val Pro Asp Ile Ser Gly Ser Val Tyr Ser Lys Thr Gln Gln Ser 
            980                 985                 990         


Phe Glu Lys Gln Gly Phe His Ser  Gly Thr Pro Ala Ala  Ser Phe Asn 
        995                 1000                 1005             


Leu Pro  Ser Ala Leu Gly Ser  Gly Gly Pro Ile Asn  Pro Ala Thr 
    1010                 1015                 1020             


Ala Ala  Ala Tyr Pro Pro Ala  Pro Phe Met His Ile  Leu Thr Pro 
    1025                 1030                 1035             


His Gln  Gln Pro His Ser Gln  Ile Leu His His His  Leu Gln Gln 
    1040                 1045                 1050             


Asp Gly  Gln Thr Gly Ser Gly  Gln Arg Ser Gln Thr  Ser Ser Ile 
    1055                 1060                 1065             


Pro Gln  Lys Pro Gln Thr Asn  Lys Ser Ala Tyr Asn  Ser Tyr Ser 
    1070                 1075                 1080             


Trp Gly  Ala Asn 
    1085         

<210>  54
<211>  1052
<212>  DNA
<213>  Homo sapiens

<400>  54
acgtccggct taccgtcgtt tacgacagtg tcaggatcgc gggcttgctt tccggtagcg     60

tgggctgacg cctcgctcaa tttctcacag ggctgcgcag gtttcccccg tctgcgaatg    120

gaccactgga ggggttcaaa ggttcgcgtc ccagtacggg aatgagcctc tttgatctct    180

tccggggctt tttcggcttt cctggacctc ggagcttcag cccaggagga gggatacgtt    240

tccacgataa cttcggcttt gatgacctag tacgagattt caatagcatc ttcagcgata    300

tgggggcctg gaccttgcct tcccatcctc ctgaacttcc aggtcctgag tcagagacac    360

ctggtgagag actacgggag ggacagacac ttcgggactc aatgcttaag tatccagata    420

gtcaccagcc caggatcttt gggggggtct tggagagtga tgcaagaagt gaatcccccc    480

aaccagcacc agactggggc tcccagaggc catttcatag gtttgatgat gtatggccta    540

tggaccccca tcctagaacc agagaggaca atgatcttga ttcccaggtt tcccaggagg    600

gtcttggccc ggttctacag ccccagccca aatcctattt caagagcatc tctgtgacca    660

agatcactaa accagatggg atagtggagg agcgccggac tgtggtggac agtgagggcc    720

ggacagagac tacagtaacc cgacacgaag cagatagcag tcctaggggt gatccagaat    780

caccaagacc tccagccctg gatgatgcct tttccatcct ggacttattc ctgggacgtt    840

ggttccggtc ccggtagcct tgttaaccct cagaggcctt caagtccttt ccacctctca    900

cccattgccc accattaata agcttagctt ctcttgccac ctcaggggct tggatatgtg    960

gaatagtgaa ctggggccat gtcagtttgt cactcaccca aactgaccaa taaaaccttt   1020

atttatgcta aaaaaaaaaa aaaaaaaaaa aa                                 1052


<210>  55
<211>  231
<212>  PRT
<213>  Homo sapiens

<400>  55


Met Ser Leu Phe Asp Leu Phe Arg Gly Phe Phe Gly Phe Pro Gly Pro 
1               5                   10                  15      


Arg Ser Phe Ser Pro Gly Gly Gly Ile Arg Phe His Asp Asn Phe Gly 
            20                  25                  30          


Phe Asp Asp Leu Val Arg Asp Phe Asn Ser Ile Phe Ser Asp Met Gly 
        35                  40                  45              


Ala Trp Thr Leu Pro Ser His Pro Pro Glu Leu Pro Gly Pro Glu Ser 
    50                  55                  60                  


Glu Thr Pro Gly Glu Arg Leu Arg Glu Gly Gln Thr Leu Arg Asp Ser 
65                  70                  75                  80  


Met Leu Lys Tyr Pro Asp Ser His Gln Pro Arg Ile Phe Gly Gly Val 
                85                  90                  95      


Leu Glu Ser Asp Ala Arg Ser Glu Ser Pro Gln Pro Ala Pro Asp Trp 
            100                 105                 110         


Gly Ser Gln Arg Pro Phe His Arg Phe Asp Asp Val Trp Pro Met Asp 
        115                 120                 125             


Pro His Pro Arg Thr Arg Glu Asp Asn Asp Leu Asp Ser Gln Val Ser 
    130                 135                 140                 


Gln Glu Gly Leu Gly Pro Val Leu Gln Pro Gln Pro Lys Ser Tyr Phe 
145                 150                 155                 160 


Lys Ser Ile Ser Val Thr Lys Ile Thr Lys Pro Asp Gly Ile Val Glu 
                165                 170                 175     


Glu Arg Arg Thr Val Val Asp Ser Glu Gly Arg Thr Glu Thr Thr Val 
            180                 185                 190         


Thr Arg His Glu Ala Asp Ser Ser Pro Arg Gly Asp Pro Glu Ser Pro 
        195                 200                 205             


Arg Pro Pro Ala Leu Asp Asp Ala Phe Ser Ile Leu Asp Leu Phe Leu 
    210                 215                 220                 


Gly Arg Trp Phe Arg Ser Arg 
225                 230     

<210>  56
<211>  1196
<212>  DNA
<213>  Homo sapiens

<400>  56
acgtccggct taccgtcgtt tacgacagtg tcaggatcgc gggcttgctt tccggtagcg     60

tgggctgacg cctcgctcaa tttctcacag ggctgcgcag gtttcccccg tctgcgaatg    120

gaccactgga ggggttcaaa ggttcgcgtc ccagtacggg aatgagcctc tttgatctct    180

tccggggctt tttcggcttt cctggacctc ggagccacag agatcccttt tttggaggga    240

tgactcgaga tgaagatgat gatgaggaag aagaagaaga agggggctca tggggccgtg    300

ggaacccaag gttccatagt cctcagcacc cccctgagga atttggcttc ggcttcagct    360

tcagcccagg aggagggata cgtttccacg ataacttcgg ctttgatgac ctagtacgag    420

atttcaatag catcttcagc gatatggggg cctggacctt gccttcccat cctcctgaac    480

ttccaggtcc tgagtcagag acacctggtg agagactacg ggagggacag acacttcggg    540

actcaatgct taagtatcca gatagtcacc agcccaggat ctttgggggg gtcttggaga    600

gtgatgcaag aagtgaatcc ccccaaccag caccagactg gggctcccag aggccatttc    660

ataggtttga tgatgtatgg cctatggacc cccatcctag aaccagagag gacaatgatc    720

ttgattccca ggtttcccag gagggtcttg gcccggttct acagccccag cccaaatcct    780

atttcaagag catctctgtg accaagatca ctaaaccaga tgggatagtg gaggagcgcc    840

ggactgtggt ggacagtgag ggccggacag agactacagt aacccgacac gaagcagata    900

gcagtcctag gggtgatcca gaatcaccaa gacctccagc cctggatgat gccttttcca    960

tcctggactt attcctggga cgttggttcc ggtcccggta gccttgttaa ccctcagagg   1020

ccttcaagtc ctttccacct ctcacccatt gcccaccatt aataagctta gcttctcttg   1080

ccacctcagg ggcttggata tgtggaatag tgaactgggg ccatgtcagt ttgtcactca   1140

cccaaactga ccaataaaac ctttatttat gctaaaaaaa aaaaaaaaaa aaaaaa       1196


<210>  57
<211>  279
<212>  PRT
<213>  Homo sapiens

<400>  57


Met Ser Leu Phe Asp Leu Phe Arg Gly Phe Phe Gly Phe Pro Gly Pro 
1               5                   10                  15      


Arg Ser His Arg Asp Pro Phe Phe Gly Gly Met Thr Arg Asp Glu Asp 
            20                  25                  30          


Asp Asp Glu Glu Glu Glu Glu Glu Gly Gly Ser Trp Gly Arg Gly Asn 
        35                  40                  45              


Pro Arg Phe His Ser Pro Gln His Pro Pro Glu Glu Phe Gly Phe Gly 
    50                  55                  60                  


Phe Ser Phe Ser Pro Gly Gly Gly Ile Arg Phe His Asp Asn Phe Gly 
65                  70                  75                  80  


Phe Asp Asp Leu Val Arg Asp Phe Asn Ser Ile Phe Ser Asp Met Gly 
                85                  90                  95      


Ala Trp Thr Leu Pro Ser His Pro Pro Glu Leu Pro Gly Pro Glu Ser 
            100                 105                 110         


Glu Thr Pro Gly Glu Arg Leu Arg Glu Gly Gln Thr Leu Arg Asp Ser 
        115                 120                 125             


Met Leu Lys Tyr Pro Asp Ser His Gln Pro Arg Ile Phe Gly Gly Val 
    130                 135                 140                 


Leu Glu Ser Asp Ala Arg Ser Glu Ser Pro Gln Pro Ala Pro Asp Trp 
145                 150                 155                 160 


Gly Ser Gln Arg Pro Phe His Arg Phe Asp Asp Val Trp Pro Met Asp 
                165                 170                 175     


Pro His Pro Arg Thr Arg Glu Asp Asn Asp Leu Asp Ser Gln Val Ser 
            180                 185                 190         


Gln Glu Gly Leu Gly Pro Val Leu Gln Pro Gln Pro Lys Ser Tyr Phe 
        195                 200                 205             


Lys Ser Ile Ser Val Thr Lys Ile Thr Lys Pro Asp Gly Ile Val Glu 
    210                 215                 220                 


Glu Arg Arg Thr Val Val Asp Ser Glu Gly Arg Thr Glu Thr Thr Val 
225                 230                 235                 240 


Thr Arg His Glu Ala Asp Ser Ser Pro Arg Gly Asp Pro Glu Ser Pro 
                245                 250                 255     


Arg Pro Pro Ala Leu Asp Asp Ala Phe Ser Ile Leu Asp Leu Phe Leu 
            260                 265                 270         


Gly Arg Trp Phe Arg Ser Arg 
        275                 

<210>  58
<211>  4176
<212>  DNA
<213>  Homo sapiens

<400>  58
ggcggtcccc tgttctcccc gctcaggtgc ggcgctgtgg caggaagcca ccccctcggt     60

cggccggtgc gcggggctgt tgcgccatcc gctccggctt tcgtaaccgc accctgggac    120

ggcccagaga cgctccagcg cgagttcctc aaatgttttc ctgcgttgcc aggaccgtcc    180

gccgctctga gtcatgtgcg agtgggaagt cgcactgaca ctgagccggg ccagagggag    240

aggagccgag cgcggcgcgg ggccgaggga ctcgcagtgt gtgtagagag ccgggctcct    300

gcggatgggg gctgcccccg gggcctgagc ccgcctgccc gcccaccgcc ccgccccgcc    360

cctgccaccc ctgccgcccg gttcccatta gcctgtccgc ctctgcggga ccatggagtg    420

gtagccgagg aggaagcatg ctggccgtcg gctgcgcgct gctggctgcc ctgctggccg    480

cgccgggagc ggcgctggcc ccaaggcgct gccctgcgca ggaggtggcg agaggcgtgc    540

tgaccagtct gccaggagac agcgtgactc tgacctgccc gggggtagag ccggaagaca    600

atgccactgt tcactgggtg ctcaggaagc cggctgcagg ctcccacccc agcagatggg    660

ctggcatggg aaggaggctg ctgctgaggt cggtgcagct ccacgactct ggaaactatt    720

catgctaccg ggccggccgc ccagctggga ctgtgcactt gctggtggat gttccccccg    780

aggagcccca gctctcctgc ttccggaaga gccccctcag caatgttgtt tgtgagtggg    840

gtcctcggag caccccatcc ctgacgacaa aggctgtgct cttggtgagg aagtttcaga    900

acagtccggc cgaagacttc caggagccgt gccagtattc ccaggagtcc cagaagttct    960

cctgccagtt agcagtcccg gagggagaca gctctttcta catagtgtcc atgtgcgtcg   1020

ccagtagtgt cgggagcaag ttcagcaaaa ctcaaacctt tcagggttgt ggaatcttgc   1080

agcctgatcc gcctgccaac atcacagtca ctgccgtggc cagaaacccc cgctggctca   1140

gtgtcacctg gcaagacccc cactcctgga actcatcttt ctacagacta cggtttgagc   1200

tcagatatcg ggctgaacgg tcaaagacat tcacaacatg gatggtcaag gacctccagc   1260

atcactgtgt catccacgac gcctggagcg gcctgaggca cgtggtgcag cttcgtgccc   1320

aggaggagtt cgggcaaggc gagtggagcg agtggagccc ggaggccatg ggcacgcctt   1380

ggacagaatc caggagtcct ccagctgaga acgaggtgtc cacccccatg caggcactta   1440

ctactaataa agacgatgat aatattctct tcagagattc tgcaaatgcg acaagcctcc   1500

cagtgcaaga ttcttcttca gtaccactgc ccacattcct ggttgctgga gggagcctgg   1560

ccttcggaac gctcctctgc attgccattg ttctgaggtt caagaagacg tggaagctgc   1620

gggctctgaa ggaaggcaag acaagcatgc atccgccgta ctctttgggg cagctggtcc   1680

cggagaggcc tcgacccacc ccagtgcttg ttcctctcat ctccccaccg gtgtccccca   1740

gcagcctggg gtctgacaat acctcgagcc acaaccgacc agatgccagg gacccacgga   1800

gcccttatga catcagcaat acagactact tcttccccag atagctggct gggtggcacc   1860

agcagcctgg accctgtgga tgataaaaca caaacgggct cagcaaaaga tgcttctcac   1920

tgccatgcca gcttatctca ggggtgtgcg gcctttggct tcacggaaga gccttgcgga   1980

aggttctacg ccaggggaaa atcagcctgc tccagctgtt cagctggttg aggtttcaaa   2040

cctccctttc caaatgccca gcttaaaggg gctagagtga acttgggcca ctgtgaagag   2100

aaccatatca agactctttg gacactcaca cggacactca aaagctgggc aggttggtgg   2160

gggcctcggt gtggagaagc ggctggcagc ccacccctca acacctctgc acaagctgca   2220

ccctcaggca ggtgggatgg atttccagcc aaagcctcct ccagccgcca tgctcctggc   2280

ccactgcatc gtttcatctt ccaactcaaa ctcttaaaac ccaagtgcct tagcaaattc   2340

tgtttttcta ggcctgggga cggcttttac ttaaaccgcc aaggctgggg gaagaagctc   2400

tctcctccct ttcttcccta cagttgaaaa acagctgagg gtgagtgggt gaataataca   2460

gtatctcagg gcctggtcgt tttcaacaga attataatta gttcctcatt agcattttgc   2520

taaatgtgaa tgatgatcct aggcatttgc tgaatacaga ggcaactgca ttggctttgg   2580

gttgcaggac ctcaggtgag aagcagagga aggagaggag aggggcacag ggtctctacc   2640

atcccctgta gagtgggagc tgagtggggg atcacagcct ctgaaaacca atgttctctc   2700

ttctccacct cccacaaagg agagctagca gcagggaggg cttctgccat ttctgagatc   2760

aaaacggttt tactgcagct ttgtttgttg tcagctgaac ctgggtaact agggaagata   2820

atattaagga agacaatgtg aaaagaaaaa tgagcctggc aagaatgtgt ttaaacttgg   2880

tttttaaaaa actgctgact gttttctctt gagagggtgg aatatccaat attcgctgtg   2940

tcagcataga agtaacttac ttaggtgtgg gggaagcacc ataactttgt ttagcccaaa   3000

accaagtcaa gtgaaaaagg aggaagagaa aaaatatttt cctgccaggc atggtggccc   3060

acgcacttcg ggaggtcgag gcaggaggat cacttgagtc cagaagtttg agatcagcct   3120

gggcaatgtg ataaaacccc atctctacaa aaagcataaa aattagccaa gtgtggtaga   3180

gtgtgcctga agtcccagat acttgggggg ctgaggtggg aggatctctt gagcctggga   3240

ggtcaaggct gcagtgagcc gagattgcac cactgcactc cagcctgggt gacagagcaa   3300

gtgagaccct gtctcaaaaa aagaaaaaga aaaagaaaaa atattttccc tattagagaa   3360

gagattgtgg tttcattctg tattttgttt ttgtcttaaa aagtggaaaa atagcctgcc   3420

tcttctctac tctagggaaa aaccagcgtg tgactactcc cccaggtggt tatggagagg   3480

gtgtccggtc cctgtcccag tgccgagaag gaagcctccc acgactgccc ggcagggtcc   3540

tagaaattcc ccaccctgaa agccctgagc tttctgctat caaagaggtt ttaaaaaaat   3600

cccatttaaa aaaaatccct tacctcggtg ccttcctctt tttatttagt tccttgagtt   3660

gattcagctc tgcaagaatt gaagcaggac taaatgtcta gttgtaacac catgattaac   3720

cacttcagct gacttttctg tccgagcttt gaaaattcag tggtgttagt ggttacccag   3780

ttagctctca agttatcagg gtattccaga gtggggatat gatttaaatc agccgtgtaa   3840

ccatggaccc aatatttacc agaccacaaa acttttctaa tactctaccc tcttagaaaa   3900

accaccacca tcaccagaca ggtgcgaaag gatgaaagtg accatgtttt gtttacggtt   3960

ttccaggttt aagctgttac tgtcttcagt aagccgtgat tttcattgct gggcttgtct   4020

gtagatttta gaccctattg ctgcttgagg caactcatct taggttggca aaaaggcagg   4080

atggccgggc gcggtggctc acgcctgtaa tcctagcact ttgggaggcc aaggtgggag   4140

gattgcttga gctcaggagt ttgagaccaa cctggg                             4176


<210>  59
<211>  468
<212>  PRT
<213>  Homo sapiens

<400>  59


Met Leu Ala Val Gly Cys Ala Leu Leu Ala Ala Leu Leu Ala Ala Pro 
1               5                   10                  15      


Gly Ala Ala Leu Ala Pro Arg Arg Cys Pro Ala Gln Glu Val Ala Arg 
            20                  25                  30          


Gly Val Leu Thr Ser Leu Pro Gly Asp Ser Val Thr Leu Thr Cys Pro 
        35                  40                  45              


Gly Val Glu Pro Glu Asp Asn Ala Thr Val His Trp Val Leu Arg Lys 
    50                  55                  60                  


Pro Ala Ala Gly Ser His Pro Ser Arg Trp Ala Gly Met Gly Arg Arg 
65                  70                  75                  80  


Leu Leu Leu Arg Ser Val Gln Leu His Asp Ser Gly Asn Tyr Ser Cys 
                85                  90                  95      


Tyr Arg Ala Gly Arg Pro Ala Gly Thr Val His Leu Leu Val Asp Val 
            100                 105                 110         


Pro Pro Glu Glu Pro Gln Leu Ser Cys Phe Arg Lys Ser Pro Leu Ser 
        115                 120                 125             


Asn Val Val Cys Glu Trp Gly Pro Arg Ser Thr Pro Ser Leu Thr Thr 
    130                 135                 140                 


Lys Ala Val Leu Leu Val Arg Lys Phe Gln Asn Ser Pro Ala Glu Asp 
145                 150                 155                 160 


Phe Gln Glu Pro Cys Gln Tyr Ser Gln Glu Ser Gln Lys Phe Ser Cys 
                165                 170                 175     


Gln Leu Ala Val Pro Glu Gly Asp Ser Ser Phe Tyr Ile Val Ser Met 
            180                 185                 190         


Cys Val Ala Ser Ser Val Gly Ser Lys Phe Ser Lys Thr Gln Thr Phe 
        195                 200                 205             


Gln Gly Cys Gly Ile Leu Gln Pro Asp Pro Pro Ala Asn Ile Thr Val 
    210                 215                 220                 


Thr Ala Val Ala Arg Asn Pro Arg Trp Leu Ser Val Thr Trp Gln Asp 
225                 230                 235                 240 


Pro His Ser Trp Asn Ser Ser Phe Tyr Arg Leu Arg Phe Glu Leu Arg 
                245                 250                 255     


Tyr Arg Ala Glu Arg Ser Lys Thr Phe Thr Thr Trp Met Val Lys Asp 
            260                 265                 270         


Leu Gln His His Cys Val Ile His Asp Ala Trp Ser Gly Leu Arg His 
        275                 280                 285             


Val Val Gln Leu Arg Ala Gln Glu Glu Phe Gly Gln Gly Glu Trp Ser 
    290                 295                 300                 


Glu Trp Ser Pro Glu Ala Met Gly Thr Pro Trp Thr Glu Ser Arg Ser 
305                 310                 315                 320 


Pro Pro Ala Glu Asn Glu Val Ser Thr Pro Met Gln Ala Leu Thr Thr 
                325                 330                 335     


Asn Lys Asp Asp Asp Asn Ile Leu Phe Arg Asp Ser Ala Asn Ala Thr 
            340                 345                 350         


Ser Leu Pro Val Gln Asp Ser Ser Ser Val Pro Leu Pro Thr Phe Leu 
        355                 360                 365             


Val Ala Gly Gly Ser Leu Ala Phe Gly Thr Leu Leu Cys Ile Ala Ile 
    370                 375                 380                 


Val Leu Arg Phe Lys Lys Thr Trp Lys Leu Arg Ala Leu Lys Glu Gly 
385                 390                 395                 400 


Lys Thr Ser Met His Pro Pro Tyr Ser Leu Gly Gln Leu Val Pro Glu 
                405                 410                 415     


Arg Pro Arg Pro Thr Pro Val Leu Val Pro Leu Ile Ser Pro Pro Val 
            420                 425                 430         


Ser Pro Ser Ser Leu Gly Ser Asp Asn Thr Ser Ser His Asn Arg Pro 
        435                 440                 445             


Asp Ala Arg Asp Pro Arg Ser Pro Tyr Asp Ile Ser Asn Thr Asp Tyr 
    450                 455                 460                 


Phe Phe Pro Arg 
465             

<210>  60
<211>  4082
<212>  DNA
<213>  Homo sapiens

<400>  60
ggcggtcccc tgttctcccc gctcaggtgc ggcgctgtgg caggaagcca ccccctcggt     60

cggccggtgc gcggggctgt tgcgccatcc gctccggctt tcgtaaccgc accctgggac    120

ggcccagaga cgctccagcg cgagttcctc aaatgttttc ctgcgttgcc aggaccgtcc    180

gccgctctga gtcatgtgcg agtgggaagt cgcactgaca ctgagccggg ccagagggag    240

aggagccgag cgcggcgcgg ggccgaggga ctcgcagtgt gtgtagagag ccgggctcct    300

gcggatgggg gctgcccccg gggcctgagc ccgcctgccc gcccaccgcc ccgccccgcc    360

cctgccaccc ctgccgcccg gttcccatta gcctgtccgc ctctgcggga ccatggagtg    420

gtagccgagg aggaagcatg ctggccgtcg gctgcgcgct gctggctgcc ctgctggccg    480

cgccgggagc ggcgctggcc ccaaggcgct gccctgcgca ggaggtggcg agaggcgtgc    540

tgaccagtct gccaggagac agcgtgactc tgacctgccc gggggtagag ccggaagaca    600

atgccactgt tcactgggtg ctcaggaagc cggctgcagg ctcccacccc agcagatggg    660

ctggcatggg aaggaggctg ctgctgaggt cggtgcagct ccacgactct ggaaactatt    720

catgctaccg ggccggccgc ccagctggga ctgtgcactt gctggtggat gttccccccg    780

aggagcccca gctctcctgc ttccggaaga gccccctcag caatgttgtt tgtgagtggg    840

gtcctcggag caccccatcc ctgacgacaa aggctgtgct cttggtgagg aagtttcaga    900

acagtccggc cgaagacttc caggagccgt gccagtattc ccaggagtcc cagaagttct    960

cctgccagtt agcagtcccg gagggagaca gctctttcta catagtgtcc atgtgcgtcg   1020

ccagtagtgt cgggagcaag ttcagcaaaa ctcaaacctt tcagggttgt ggaatcttgc   1080

agcctgatcc gcctgccaac atcacagtca ctgccgtggc cagaaacccc cgctggctca   1140

gtgtcacctg gcaagacccc cactcctgga actcatcttt ctacagacta cggtttgagc   1200

tcagatatcg ggctgaacgg tcaaagacat tcacaacatg gatggtcaag gacctccagc   1260

atcactgtgt catccacgac gcctggagcg gcctgaggca cgtggtgcag cttcgtgccc   1320

aggaggagtt cgggcaaggc gagtggagcg agtggagccc ggaggccatg ggcacgcctt   1380

ggacagaatc caggagtcct ccagctgaga acgaggtgtc cacccccatg caggcactta   1440

ctactaataa agacgatgat aatattctct tcagagattc tgcaaatgcg acaagcctcc   1500

caggttcaag aagacgtgga agctgcgggc tctgaaggaa ggcaagacaa gcatgcatcc   1560

gccgtactct ttggggcagc tggtcccgga gaggcctcga cccaccccag tgcttgttcc   1620

tctcatctcc ccaccggtgt cccccagcag cctggggtct gacaatacct cgagccacaa   1680

ccgaccagat gccagggacc cacggagccc ttatgacatc agcaatacag actacttctt   1740

ccccagatag ctggctgggt ggcaccagca gcctggaccc tgtggatgat aaaacacaaa   1800

cgggctcagc aaaagatgct tctcactgcc atgccagctt atctcagggg tgtgcggcct   1860

ttggcttcac ggaagagcct tgcggaaggt tctacgccag gggaaaatca gcctgctcca   1920

gctgttcagc tggttgaggt ttcaaacctc cctttccaaa tgcccagctt aaaggggcta   1980

gagtgaactt gggccactgt gaagagaacc atatcaagac tctttggaca ctcacacgga   2040

cactcaaaag ctgggcaggt tggtgggggc ctcggtgtgg agaagcggct ggcagcccac   2100

ccctcaacac ctctgcacaa gctgcaccct caggcaggtg ggatggattt ccagccaaag   2160

cctcctccag ccgccatgct cctggcccac tgcatcgttt catcttccaa ctcaaactct   2220

taaaacccaa gtgccttagc aaattctgtt tttctaggcc tggggacggc ttttacttaa   2280

accgccaagg ctgggggaag aagctctctc ctccctttct tccctacagt tgaaaaacag   2340

ctgagggtga gtgggtgaat aatacagtat ctcagggcct ggtcgttttc aacagaatta   2400

taattagttc ctcattagca ttttgctaaa tgtgaatgat gatcctaggc atttgctgaa   2460

tacagaggca actgcattgg ctttgggttg caggacctca ggtgagaagc agaggaagga   2520

gaggagaggg gcacagggtc tctaccatcc cctgtagagt gggagctgag tgggggatca   2580

cagcctctga aaaccaatgt tctctcttct ccacctccca caaaggagag ctagcagcag   2640

ggagggcttc tgccatttct gagatcaaaa cggttttact gcagctttgt ttgttgtcag   2700

ctgaacctgg gtaactaggg aagataatat taaggaagac aatgtgaaaa gaaaaatgag   2760

cctggcaaga atgtgtttaa acttggtttt taaaaaactg ctgactgttt tctcttgaga   2820

gggtggaata tccaatattc gctgtgtcag catagaagta acttacttag gtgtggggga   2880

agcaccataa ctttgtttag cccaaaacca agtcaagtga aaaaggagga agagaaaaaa   2940

tattttcctg ccaggcatgg tggcccacgc acttcgggag gtcgaggcag gaggatcact   3000

tgagtccaga agtttgagat cagcctgggc aatgtgataa aaccccatct ctacaaaaag   3060

cataaaaatt agccaagtgt ggtagagtgt gcctgaagtc ccagatactt ggggggctga   3120

ggtgggagga tctcttgagc ctgggaggtc aaggctgcag tgagccgaga ttgcaccact   3180

gcactccagc ctgggtgaca gagcaagtga gaccctgtct caaaaaaaga aaaagaaaaa   3240

gaaaaaatat tttccctatt agagaagaga ttgtggtttc attctgtatt ttgtttttgt   3300

cttaaaaagt ggaaaaatag cctgcctctt ctctactcta gggaaaaacc agcgtgtgac   3360

tactccccca ggtggttatg gagagggtgt ccggtccctg tcccagtgcc gagaaggaag   3420

cctcccacga ctgcccggca gggtcctaga aattccccac cctgaaagcc ctgagctttc   3480

tgctatcaaa gaggttttaa aaaaatccca tttaaaaaaa atcccttacc tcggtgcctt   3540

cctcttttta tttagttcct tgagttgatt cagctctgca agaattgaag caggactaaa   3600

tgtctagttg taacaccatg attaaccact tcagctgact tttctgtccg agctttgaaa   3660

attcagtggt gttagtggtt acccagttag ctctcaagtt atcagggtat tccagagtgg   3720

ggatatgatt taaatcagcc gtgtaaccat ggacccaata tttaccagac cacaaaactt   3780

ttctaatact ctaccctctt agaaaaacca ccaccatcac cagacaggtg cgaaaggatg   3840

aaagtgacca tgttttgttt acggttttcc aggtttaagc tgttactgtc ttcagtaagc   3900

cgtgattttc attgctgggc ttgtctgtag attttagacc ctattgctgc ttgaggcaac   3960

tcatcttagg ttggcaaaaa ggcaggatgg ccgggcgcgg tggctcacgc ctgtaatcct   4020

agcactttgg gaggccaagg tgggaggatt gcttgagctc aggagtttga gaccaacctg   4080

gg                                                                  4082


<210>  61
<211>  365
<212>  PRT
<213>  Homo sapiens

<400>  61


Met Leu Ala Val Gly Cys Ala Leu Leu Ala Ala Leu Leu Ala Ala Pro 
1               5                   10                  15      


Gly Ala Ala Leu Ala Pro Arg Arg Cys Pro Ala Gln Glu Val Ala Arg 
            20                  25                  30          


Gly Val Leu Thr Ser Leu Pro Gly Asp Ser Val Thr Leu Thr Cys Pro 
        35                  40                  45              


Gly Val Glu Pro Glu Asp Asn Ala Thr Val His Trp Val Leu Arg Lys 
    50                  55                  60                  


Pro Ala Ala Gly Ser His Pro Ser Arg Trp Ala Gly Met Gly Arg Arg 
65                  70                  75                  80  


Leu Leu Leu Arg Ser Val Gln Leu His Asp Ser Gly Asn Tyr Ser Cys 
                85                  90                  95      


Tyr Arg Ala Gly Arg Pro Ala Gly Thr Val His Leu Leu Val Asp Val 
            100                 105                 110         


Pro Pro Glu Glu Pro Gln Leu Ser Cys Phe Arg Lys Ser Pro Leu Ser 
        115                 120                 125             


Asn Val Val Cys Glu Trp Gly Pro Arg Ser Thr Pro Ser Leu Thr Thr 
    130                 135                 140                 


Lys Ala Val Leu Leu Val Arg Lys Phe Gln Asn Ser Pro Ala Glu Asp 
145                 150                 155                 160 


Phe Gln Glu Pro Cys Gln Tyr Ser Gln Glu Ser Gln Lys Phe Ser Cys 
                165                 170                 175     


Gln Leu Ala Val Pro Glu Gly Asp Ser Ser Phe Tyr Ile Val Ser Met 
            180                 185                 190         


Cys Val Ala Ser Ser Val Gly Ser Lys Phe Ser Lys Thr Gln Thr Phe 
        195                 200                 205             


Gln Gly Cys Gly Ile Leu Gln Pro Asp Pro Pro Ala Asn Ile Thr Val 
    210                 215                 220                 


Thr Ala Val Ala Arg Asn Pro Arg Trp Leu Ser Val Thr Trp Gln Asp 
225                 230                 235                 240 


Pro His Ser Trp Asn Ser Ser Phe Tyr Arg Leu Arg Phe Glu Leu Arg 
                245                 250                 255     


Tyr Arg Ala Glu Arg Ser Lys Thr Phe Thr Thr Trp Met Val Lys Asp 
            260                 265                 270         


Leu Gln His His Cys Val Ile His Asp Ala Trp Ser Gly Leu Arg His 
        275                 280                 285             


Val Val Gln Leu Arg Ala Gln Glu Glu Phe Gly Gln Gly Glu Trp Ser 
    290                 295                 300                 


Glu Trp Ser Pro Glu Ala Met Gly Thr Pro Trp Thr Glu Ser Arg Ser 
305                 310                 315                 320 


Pro Pro Ala Glu Asn Glu Val Ser Thr Pro Met Gln Ala Leu Thr Thr 
                325                 330                 335     


Asn Lys Asp Asp Asp Asn Ile Leu Phe Arg Asp Ser Ala Asn Ala Thr 
            340                 345                 350         


Ser Leu Pro Gly Ser Arg Arg Arg Gly Ser Cys Gly Leu 
        355                 360                 365 

<210>  62
<211>  6243
<212>  DNA
<213>  Homo sapiens

<400>  62
gccgggcgtg ggcgacggcc ggccgggggc gcacggagca gccgtcgcgg ggcctcgccg     60

cggcctccag cgccccagtc acggggaatg cagtggtccc cgacccctgg cgcctctgcg    120

tgtctgggct gggcttcctc gctcgcctgc tccacggccc cgacgctcct gggccgagcc    180

ggccggggcc ccctcatggc ggccaagtgg ttcaaggagt tccccctgaa cctgaagacc    240

gtgtcggagc gggccaagcc cgggggcggc ggcggcaaat tgcgcaagaa ctcggaggcg    300

ggcggcgctg ggccgggtcc tggcaagggc cgcaagaact cggcggccga gctggggagc    360

ggcagggccg gcgtcggccc caaggacagc cggctgtccc gcgacagcct gcagggtctg    420

attcaggccg ccgcgggcaa gggccgcaaa aactcccggg ccacggagga ggagccccac    480

cggggtgcaa ccaagagctc gggctgcagc acctacatca acaggctcat caaggtggac    540

actcaggaga agaacgggaa gagcaactac cccagcagca gtagctccag ctccagctcc    600

tcttcctccg cgtcctcttc cccttcctcc ctggggcccg agctggacaa gggcaagatt    660

attaagcagc aagagacggt catcatttta gaagactatg ctgaccctta tgatgccaaa    720

cggacaaagg gtcaaaggga tgcagagaga gtcggagaga acgacggtta catggaacca    780

tatgatgcac agcaaatgat aacagaaatt agacgacggg gttccaaaga tcccctggtg    840

aaggctctcc agctgcttga cagtccctgt gaacccgcag acggtggcct gaaatcagag    900

accttggcca aaagacggag ttccaaggac ctcctgggga agccgccaca gctatacgac    960

actccctacg agcctgcaga aggggggccc agggcagagg ggaaggcgcg gcccccagac   1020

agccggctgc ccgagaacga cgagaggccc gcggcagagt acgagcagcc atgggagtgg   1080

aagaaggagc agatcgtgcg ggctctgtca gtccagtttg aaggagctga gcgaccttcc   1140

ttcagggagg agacagtgag gcagcaccac cggcagaaga gctggaccca gaagatcctg   1200

aagccagccc tctcggacca cagtgaggga gagaaagtgg acccgggcct gcccctggag   1260

aagcagccct ggtatcatgg tgccatcagc cgtgctgagg ctgagagtcg actacagccc   1320

tgcaaagaag ctggttacct ggttcgaaat agtgagtcag ggaacagcag gtactccatt   1380

gccctaaaga ctagtcaagg atgtgtccac atcatagtgg ctcagaccaa agacaacaaa   1440

tacacactga atcagacaag cgctgtgttt gacagcatcc ctgaagtggt acactattat   1500

tccaatgaaa agttgccttt caaaggggca gaacacatga ctttactcta cccagtgcac   1560

agcaagcttc actaagattc agccactgca agccctgggc ctctggcacc ttcaagggca   1620

tcatcagcgc acaaccagca tctcagagga caaggctgga ctagcaactg ctagaaaatg   1680

ggagtcttcc ttgaaaagtc agagagtgat ttgttttgtt ttgtttgaga cgaagtctcg   1740

ctgtgttgcc caggctggag tgcaatggcg caatcttggc tcactgcaac atctgactcc   1800

tgggttcaag cagttcttcc ccatcagcct cccaagtagg tgggactata ggttcgcacc   1860

accactccca gctaattttt ttttttgtat ttttagtaga gatggggttt cgccgtcttc   1920

gtcaggctgg tctcaaactc ctgacctcaa atgatccacc cacctcagtc tccccgagtg   1980

cctggattac aggcatgagc cactgcaccc ggccaagtct ttggtcttaa agtgattcca   2040

tgacactttg tttgtggcct gtcccttgtt tccttgctaa gtagttctac aataagaaat   2100

catgatttag ctgttgcctc cagctctggg gtagggtgtt ctttttatgg tgtgaccctc   2160

aggaaggtta agtcaggagt tcaggagcat cagagttctc tagaaatgtg cctacttgtt   2220

acctggaata cctggtctct aaacaaacca acaaaaaatc cacgtggctt ttccacatga   2280

tggtgcagac tggaagagga tgttatattg gactcgttat tggggaaatg aatgagcggg   2340

agaaaatgtg aatgacgggc aagaaggtgg tctttctccc tcagaagtcc taattcagct   2400

ctggagttca tggaaatccg caacttcaga gtgtggccta aggattattt tgttggtcag   2460

cctttccaag aaagtgtgtg ttctctcaat ctctgtggat tttctcattt tttagcaaat   2520

cagtgagata agcataaata ggaaggaaga taccccaggt ttaagaatca ccaatatcat   2580

taggcattgg catcattatt agaattctga attatagaat aaaaggtaca acaaaaattt   2640

catttctgaa ttttaaaatt ctggaaattt gcaaagctcc acaactgttt ttttactgaa   2700

ttaattacat agaacttcga tgtcttttgt ttcatcatca ttgggcattt tagttgctat   2760

ggaataattt ttaatttttg tctctaaaat tagatttgct ttgtagtaaa ttttttaaaa   2820

atgcaaccct aagatctgat tatatgaact gggtctctaa agcctacaaa gattctctcg   2880

ttctgtacca agcagactgc cttgtactat acagaagtgt ttgaaaagac ctagaggttt   2940

tctcttaaat accattactt aagattcata gtattaggat ctttatgatt tatcatgagc   3000

ttatatcacc agtttattta ctgtgaaaaa aaccatggga atggcatact gtgagaagag   3060

tactatggtg aatggctcca gaattaaaat tcagcagatg tgtctgtatt ctggggttgg   3120

tcatttgggt ctcaaaactg ccccatatgc aaatgtactg actgtcatca atgaaaagtt   3180

aacctttgta gcttataaat acacacaaaa tgttgatttg gttaattttt taggaaagta   3240

tacctttgta gttactagtt acatttgact gtaagattta gaggttagta aatttttgct   3300

tctttattca gataagatct cagccaaaag gttgtgtgat ctttgatttt aaaaatttaa   3360

gaggaacttt tcctcactgg aacacaatga ttttattaat aaagaatgta ggctgggtgc   3420

ggtggctcat gcacgtaatc ccaacaattt gggaggctga ggcaggcaga tcacgtgagg   3480

tcaggagttt gagaccagcc tggccaacat ggtgaaaccc tgtctgtagt aaaaatacaa   3540

aaattagctg ggcacggtgg cgggcacctg tagttccagc tgcttgggag gctgaggcac   3600

gagaatcact tgagcccagg aggtggaggt tgcagtgagc caagattatg tcactgcact   3660

ccatcctggg tgacaagagc gaaactccat ctcaaaaaaa aaaaaaaaaa aaagcctggc   3720

ctggtggtgg atgcctgtgg ttccagctat tcgggaggct gaggtaggtg gatcacctct   3780

gctcaggtca aggctgcagc gagccatgat cgcaccattg cactccagcc tgagtgacag   3840

agtgagaccc tgtctcaaca agcaagcaaa caaaaaacca aaaggaatgt ttttttcaga   3900

tactgataga atgttttcag tgtgtattgg ttcatttact atatctttag tgtaagattt   3960

taaaaggttt tttcagcatc cattcaacaa atatttatta tctttataca aattattcat   4020

tgtgttaaac ttatttttag tttaacattc tagaaatgaa acgtttttac ttaaccttat   4080

tctacaaagg gaatacagca gttattctaa ttttaataaa tgctaaaagc tttatacaat   4140

ttttctttgt gcactaaatg atttttggcc catacccagc aactgtgatg aatgtataat   4200

gaaataacat cttgaaaaca ggccagatac attaagtatt tattgagctt ctgtcatatg   4260

cccagtatta tgcttcttct atactgtttc tctgtgacaa gtcatactat attctttata   4320

gaattaaaag tagaggagag gcagagttta catattgtcc agttgcttta cagttgtaca   4380

ggaggttata agaagaaata tagtaaatta gtgggaagtc agaggtgggg gcgttagtga   4440

gctattttct tcttgaggtt gtgacacaag ctgacaaaag ccagggagtt cacagctgtg   4500

tggtggcaca aagttccata tgttctaaaa acaattaggc ccagcagggt gtccctaatg   4560

gcttccttgt taaacctcca tggccagctg atctgaagct ctgtgacatg ttctctgagc   4620

tctgaatgct ctggcttttt gtcattttgt cttgagacaa gtattttcct gtagtcctca   4680

ttccttcgag ttattccatc tcccaggata ttctctggtg agaagaatgt ctttcagtga   4740

atttgccttg aatttagcat ccatagagct gtgtcagtgt tcttcttgat cacaccttct   4800

ttaaaaaaaa tacttgcttg cgatgactgg acaagttcag ttggttagtt tcaggcctat   4860

aagaagagag agtaaaggac cttgctattt actttgatac catagttgta tctcaggatg   4920

gcctgcaaac cactggcctt gtgtgtattt aagctaggaa taaaataatg gagaagtgtt   4980

aatatgtata caaaaaggta aatattgata tatctactct ctgttggggg cagaagtgtc   5040

attttaagtt attcaaagca ctttcttaag cattttagaa agcctttatt ctttgctgtt   5100

ggaagtctcc gtactttgca gaattggtat ttgtgtacta gcctctgccg caggatgggg   5160

aggtgggcag gtagctgata ggggcagcca ggagtttttg aggcaggtgg tgggaaattg   5220

tcctaatttg ttaattggat tatgtaactc tgttactagt ctgttattgg ctgttgttac   5280

tggatgcatc ttgatattca gaagaataac tgtgaggcat tcttcagttg cgggttaagt   5340

ggggttagtt tctgttctgt cagatgccct ttttcagtca aaggttagcc ccttgtttct   5400

ccctccttcc agggtttagg gagtgcagtg atgtcgattt catttccctt ccccgcaccc   5460

cttgacactc agcaggattg cactgaaacc cttcacagat ctctcgttca ctagttgtct   5520

cctatttttc cataactagc actagtttgg ccttatgacc tggttagaat cactcttctg   5580

tattctcatt tccaattttt gtgccccact aacgtggact agagaaactt ggcctgctgt   5640

gcagtgggcc ttctgttcaa cttaccctcc accgctgacc ctgtgtgaag agagatggtg   5700

cgttactgcc atctaatggg aaaagagaaa actgcagttg ggaaaagcag ctgtgcattt   5760

aagggtaggg ctttctgaag gatttctgat acagtccaga aaagggaaaa tgatgacaca   5820

gcagttgcca tcttgaaaaa tgccctttcc tgcggaaagg gtgttttgaa gtctaataca   5880

actatcatca caaggtccct ggactaaggc tggatcgtgt aatttagaat ctcaaattgt   5940

attttaatta atatgctggc aacagaatca ttgaaacagg cgtctcattt tgtcaagttc   6000

ttagccgttc agtttgtcag gggctttaat attttagata tcaactaata catagtttca   6060

acttttaaaa atgtttgaag attgtatgta atataggtgt ctatctatag tgccttagta   6120

atttaaatca gaaatatttt ataaaacttc tggttgtttt gcagtagcca atataggctt   6180

catgccctcc tgaagatagt ttcctctgaa atgtaacttt aaataaacat tattccaaga   6240

aaa                                                                 6243


<210>  63
<211>  495
<212>  PRT
<213>  Homo sapiens

<400>  63


Met Gln Trp Ser Pro Thr Pro Gly Ala Ser Ala Cys Leu Gly Trp Ala 
1               5                   10                  15      


Ser Ser Leu Ala Cys Ser Thr Ala Pro Thr Leu Leu Gly Arg Ala Gly 
            20                  25                  30          


Arg Gly Pro Leu Met Ala Ala Lys Trp Phe Lys Glu Phe Pro Leu Asn 
        35                  40                  45              


Leu Lys Thr Val Ser Glu Arg Ala Lys Pro Gly Gly Gly Gly Gly Lys 
    50                  55                  60                  


Leu Arg Lys Asn Ser Glu Ala Gly Gly Ala Gly Pro Gly Pro Gly Lys 
65                  70                  75                  80  


Gly Arg Lys Asn Ser Ala Ala Glu Leu Gly Ser Gly Arg Ala Gly Val 
                85                  90                  95      


Gly Pro Lys Asp Ser Arg Leu Ser Arg Asp Ser Leu Gln Gly Leu Ile 
            100                 105                 110         


Gln Ala Ala Ala Gly Lys Gly Arg Lys Asn Ser Arg Ala Thr Glu Glu 
        115                 120                 125             


Glu Pro His Arg Gly Ala Thr Lys Ser Ser Gly Cys Ser Thr Tyr Ile 
    130                 135                 140                 


Asn Arg Leu Ile Lys Val Asp Thr Gln Glu Lys Asn Gly Lys Ser Asn 
145                 150                 155                 160 


Tyr Pro Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ala Ser 
                165                 170                 175     


Ser Ser Pro Ser Ser Leu Gly Pro Glu Leu Asp Lys Gly Lys Ile Ile 
            180                 185                 190         


Lys Gln Gln Glu Thr Val Ile Ile Leu Glu Asp Tyr Ala Asp Pro Tyr 
        195                 200                 205             


Asp Ala Lys Arg Thr Lys Gly Gln Arg Asp Ala Glu Arg Val Gly Glu 
    210                 215                 220                 


Asn Asp Gly Tyr Met Glu Pro Tyr Asp Ala Gln Gln Met Ile Thr Glu 
225                 230                 235                 240 


Ile Arg Arg Arg Gly Ser Lys Asp Pro Leu Val Lys Ala Leu Gln Leu 
                245                 250                 255     


Leu Asp Ser Pro Cys Glu Pro Ala Asp Gly Gly Leu Lys Ser Glu Thr 
            260                 265                 270         


Leu Ala Lys Arg Arg Ser Ser Lys Asp Leu Leu Gly Lys Pro Pro Gln 
        275                 280                 285             


Leu Tyr Asp Thr Pro Tyr Glu Pro Ala Glu Gly Gly Pro Arg Ala Glu 
    290                 295                 300                 


Gly Lys Ala Arg Pro Pro Asp Ser Arg Leu Pro Glu Asn Asp Glu Arg 
305                 310                 315                 320 


Pro Ala Ala Glu Tyr Glu Gln Pro Trp Glu Trp Lys Lys Glu Gln Ile 
                325                 330                 335     


Val Arg Ala Leu Ser Val Gln Phe Glu Gly Ala Glu Arg Pro Ser Phe 
            340                 345                 350         


Arg Glu Glu Thr Val Arg Gln His His Arg Gln Lys Ser Trp Thr Gln 
        355                 360                 365             


Lys Ile Leu Lys Pro Ala Leu Ser Asp His Ser Glu Gly Glu Lys Val 
    370                 375                 380                 


Asp Pro Gly Leu Pro Leu Glu Lys Gln Pro Trp Tyr His Gly Ala Ile 
385                 390                 395                 400 


Ser Arg Ala Glu Ala Glu Ser Arg Leu Gln Pro Cys Lys Glu Ala Gly 
                405                 410                 415     


Tyr Leu Val Arg Asn Ser Glu Ser Gly Asn Ser Arg Tyr Ser Ile Ala 
            420                 425                 430         


Leu Lys Thr Ser Gln Gly Cys Val His Ile Ile Val Ala Gln Thr Lys 
        435                 440                 445             


Asp Asn Lys Tyr Thr Leu Asn Gln Thr Ser Ala Val Phe Asp Ser Ile 
    450                 455                 460                 


Pro Glu Val Val His Tyr Tyr Ser Asn Glu Lys Leu Pro Phe Lys Gly 
465                 470                 475                 480 


Ala Glu His Met Thr Leu Leu Tyr Pro Val His Ser Lys Leu His 
                485                 490                 495 

<210>  64
<211>  2544
<212>  DNA
<213>  Homo sapiens

<400>  64
gtcttcaacg cctgcccggc ccgaggacac cgtggctctc ggaggcggcg ggcgccgggg     60

gcttccccct gctctttcct cctgcggtgg gagaggccag gcccacggaa gccccctgcg    120

gcccagccca cgctcccagg gaccagagag gaccgagcgg aggcggcggg agtatccccg    180

gcgcagcgac agacggtgga cggacggcga gcggcccatc aactccgcgc gcccctcccc    240

tccgcggctg gcgcctccca gccccgccac ctcctgccca gagctggggg cggcggggtg    300

agcgccatgg cagaggcggg tcgggctgcg agctctggag aaaggggcgg cggccgcacg    360

tgcggatcgg ccgcgcccca ctgagcagag agcccccttc tgccgccgac agcccgcgtc    420

tgcaccgagc cggtctcggc cgggcgctgc cttcacacgc gcccaggagt gtcacgtgcg    480

ccgctcaccc ccgggaagga agcccctcgc ccacccactc cgctctactc cactctttct    540

gcagacgtta tttttggcgg tagggcagag gttgcggccc gaggtccggg cgcagggaca    600

acggtcgcca gctcctgcgc tagttccgtt actcttcggt ggcacacggt cctgggcagc    660

gcgaggctct tcccgccgtg gccgccgggg attggctgcc ggcaagcccc gccccgtgcc    720

cccgggctca gagggggcgg agcgcggagg gagaaggcgc gaaggctggg cgtcgcgatc    780

gcaggtgcac gcgcgtggcc cgcgagacga ggagatcctg ttggaaagca actgcagcat    840

gtcctggaac attagtcacc cccaactctc tgataaactg tttgggaaga atggagtgtt    900

ggaggagcag aaatctccag gattcaagaa aagagagaca gaggtgtatg ttggcaatct    960

tccactggat atttctaagg aggaaattct gtaccttcta aaggacttca accctcttga   1020

tgtccacaaa atccagaatg gctgcaaatg ctttgcattt gtagatctgg gctccatgca   1080

gaaagtgaca cttgcaatcc aggagctgaa tggtaaactc ttccacaagc gaaaactgtt   1140

cgtgaataca agcaaaaggc cccccaagag gacccctgat atgatccagc agcctcgggc   1200

cccgctggtg ttggagaagg cttctggtga aggatttggc aaaaccgccg ctattataca   1260

gctcgctcct aaagctcctg ttgacctgtg tgagacagag aaactgaggg cagccttctt   1320

tgcagtcccg ttggaaatga gagggtcctt cctggtgctg ctcctgaggg aatgcttccg   1380

agacctgagc tggctggcac tcatccatag cgtccgtggg gaggcggggc tgctggtgac   1440

gagtatcgtc ccgaagaccc cgtttttctg ggccatgcac gtcactgagg ctctgcacca   1500

gaacatgcag gctctgttta gcaccctggc tcaggcggag gagcagcagc cctacctgga   1560

gggctccacc gttatgcgcg ggactcgctg tctggcagag taccacctgg gggattatgg   1620

acacgcctgg aacaggtgtt gggtgctgga cagggtggac acctgggctg tggtcatgtt   1680

cattgatttt ggacagttgg ccaccatccc tgtgcagtct ctgcgcagcc tagacagcga   1740

cgacttctgg accatcccac ccctgactca gccattcatg ctggagaaag acattttgag   1800

ttcgtatgag gttgtccatc gaatcctcaa agggaaaatc actggtgctt tgaactcggc   1860

ggtaactgct cctgcatcta acttggctgt tgtccctcca ctcctgccct tggggtgtct   1920

gcagcaggct gctgcctagg cctggacaca gtatttacct ggcattcttt tagatcaaac   1980

gaactggtta tctgaggggt tgggtgaact ggctcgggtg ggccttcctt cccaccaagg   2040

ctttgtcttt ctcttccagt tgcacatcct aaagtttgaa gagtctaaat aacggggctt   2100

ccctcagcat gttccctctc ctgtttgcca cggatccaga ggccacctgc cctgtcttct   2160

cgtacccctt tcactcttga ggcctgggag gtgaaaaagg ccagactgtg cccaggattg   2220

attcaatttt gcttttactc ccagcttccc tctcaaaaga gagtgaagtc tcatttgtca   2280

tgtgtcttca gttccccaac ttggcatgaa catttgaacc aaacatagga aactaccatt   2340

aggttgaaag cctgaggcag ctgggatggt ctttcttgtg tctcttcttt gcaccccaga   2400

gcatgatata agtggtccta acagattctg gataatggag aagccctctg ctggttttcc   2460

tggcattcca tgtagaatag gtagagaata tttaaccaat gagcaaataa atgttggcat   2520

gtttcatgaa aaaaaaaaaa aaaa                                          2544


<210>  65
<211>  366
<212>  PRT
<213>  Homo sapiens

<400>  65


Met Ser Trp Asn Ile Ser His Pro Gln Leu Ser Asp Lys Leu Phe Gly 
1               5                   10                  15      


Lys Asn Gly Val Leu Glu Glu Gln Lys Ser Pro Gly Phe Lys Lys Arg 
            20                  25                  30          


Glu Thr Glu Val Tyr Val Gly Asn Leu Pro Leu Asp Ile Ser Lys Glu 
        35                  40                  45              


Glu Ile Leu Tyr Leu Leu Lys Asp Phe Asn Pro Leu Asp Val His Lys 
    50                  55                  60                  


Ile Gln Asn Gly Cys Lys Cys Phe Ala Phe Val Asp Leu Gly Ser Met 
65                  70                  75                  80  


Gln Lys Val Thr Leu Ala Ile Gln Glu Leu Asn Gly Lys Leu Phe His 
                85                  90                  95      


Lys Arg Lys Leu Phe Val Asn Thr Ser Lys Arg Pro Pro Lys Arg Thr 
            100                 105                 110         


Pro Asp Met Ile Gln Gln Pro Arg Ala Pro Leu Val Leu Glu Lys Ala 
        115                 120                 125             


Ser Gly Glu Gly Phe Gly Lys Thr Ala Ala Ile Ile Gln Leu Ala Pro 
    130                 135                 140                 


Lys Ala Pro Val Asp Leu Cys Glu Thr Glu Lys Leu Arg Ala Ala Phe 
145                 150                 155                 160 


Phe Ala Val Pro Leu Glu Met Arg Gly Ser Phe Leu Val Leu Leu Leu 
                165                 170                 175     


Arg Glu Cys Phe Arg Asp Leu Ser Trp Leu Ala Leu Ile His Ser Val 
            180                 185                 190         


Arg Gly Glu Ala Gly Leu Leu Val Thr Ser Ile Val Pro Lys Thr Pro 
        195                 200                 205             


Phe Phe Trp Ala Met His Val Thr Glu Ala Leu His Gln Asn Met Gln 
    210                 215                 220                 


Ala Leu Phe Ser Thr Leu Ala Gln Ala Glu Glu Gln Gln Pro Tyr Leu 
225                 230                 235                 240 


Glu Gly Ser Thr Val Met Arg Gly Thr Arg Cys Leu Ala Glu Tyr His 
                245                 250                 255     


Leu Gly Asp Tyr Gly His Ala Trp Asn Arg Cys Trp Val Leu Asp Arg 
            260                 265                 270         


Val Asp Thr Trp Ala Val Val Met Phe Ile Asp Phe Gly Gln Leu Ala 
        275                 280                 285             


Thr Ile Pro Val Gln Ser Leu Arg Ser Leu Asp Ser Asp Asp Phe Trp 
    290                 295                 300                 


Thr Ile Pro Pro Leu Thr Gln Pro Phe Met Leu Glu Lys Asp Ile Leu 
305                 310                 315                 320 


Ser Ser Tyr Glu Val Val His Arg Ile Leu Lys Gly Lys Ile Thr Gly 
                325                 330                 335     


Ala Leu Asn Ser Ala Val Thr Ala Pro Ala Ser Asn Leu Ala Val Val 
            340                 345                 350         


Pro Pro Leu Leu Pro Leu Gly Cys Leu Gln Gln Ala Ala Ala 
        355                 360                 365     

<210>  66
<211>  2346
<212>  DNA
<213>  Homo sapiens

<400>  66
gtcttcaacg cctgcccggc ccgaggacac cgtggctctc ggaggcggcg ggcgccgggg     60

gcttccccct gctctttcct cctgcggtgg gagaggccag gcccacggaa gccccctgcg    120

gcccagccca cgctcccagg gaccagagag gaccgagcgg aggcggcggg agtatccccg    180

gcgcagcgac agacggtgga cggacggcga gcggcccatc aactccgcgc gcccctcccc    240

tccgcggctg gcgcctccca gccccgccac ctcctgccca gagctggggg cggcggggtg    300

agcgccatgg cagaggcggg tcgggctgcg agctctggag aaaggggcgg cggccgcacg    360

tgcggatcgg ccgcgcccca ctgagcagag agcccccttc tgccgccgac agcccgcgtc    420

tgcaccgagc cggtctcggc cgggcgctgc cttcacacgc gcccaggagt gtcacgtgcg    480

ccgctcaccc ccgggaagga agcccctcgc ccacccactc cgctctactc cactctttct    540

gcagacgtta tttttggcgg tagggcagag gttgcggccc gaggtccggg cgcagggaca    600

acggtcgcca gctcctgcgc tagttccgtt actcttcggt ggcacacggt cctgggcagc    660

gcgaggctct tcccgccgtg gccgccgggg attggctgcc ggcaagcccc gccccgtgcc    720

cccgggctca gagggggcgg agcgcggagg gagaaggcgc gaaggctggg cgtcgcgatc    780

gcaggtgcac gcgcgtggcc cgcgagacga ggagatcctg ttggaaagca actgcagcat    840

gtcctggaac attagtcacc cccaactctc tgataaactg tttgggaaga atggagtgtt    900

ggaggagcag aaatctccag gattcaagaa aagagagaca gaggtgtatg ttggcaatct    960

tccactggat atttctaagg aggaaattct gtaccttcta aaggacttca accctcttga   1020

tgtccacaaa atccagaatg gctgcaaatg ctttgcattt gtagatctgg gctccatgca   1080

gaaagtgaca cttgcaatcc aggagctgaa tggtaaactc ttccacaagc gaaaactgtt   1140

cgtgaataca agcaaaaggc cccccaagag gacccctgat atgatccagc agcctcgggc   1200

cccgctggtg ttggagaagg cttctggtga aggatttggc aaaaccgccg ctattataca   1260

gctcgctcct aaagctcctg ttgacctgtg tgagacagag aaactgaggg cagccttctt   1320

tgcagtcccg ttggaaatga gagggtcctt cctggtgctg ctcctgaggg aatgcttccg   1380

agacctgagc tggctggcac tcatccatag cgtccgtggg gaggcggggc tgctggtgac   1440

gagtatcgtc ccgaagaccc cgtttttctg ggccatgcac gtcactgagg ctctgcacca   1500

gaacatgcag gctctgttta gcaccctggc tcaggcggag gagcagcagc cctacctgga   1560

gggctccacc gttatgcgcg ggactcgctg tctggcagag taccacctgg gggattatgg   1620

acacgcctgg aacaggtgtt gggtgctgga cagggtggac acctgggctg tggtcatgtt   1680

cattgatttt ggacagttgg ccaccatccc tgtgcagtct ctgcgcagcc tagacagcga   1740

cgacttctgg accatcccac ccctgactca gccattcatg ctggagaaag acattttgag   1800

ttcgtatgag gttgtccatc gaatcctcaa agggaaaatc actggtgctt tgaactcggc   1860

gttgcacatc ctaaagtttg aagagtctaa ataacggggc ttccctcagc atgttccctc   1920

tcctgtttgc cacggatcca gaggccacct gccctgtctt ctcgtacccc tttcactctt   1980

gaggcctggg aggtgaaaaa ggccagactg tgcccaggat tgattcaatt ttgcttttac   2040

tcccagcttc cctctcaaaa gagagtgaag tctcatttgt catgtgtctt cagttcccca   2100

acttggcatg aacatttgaa ccaaacatag gaaactacca ttaggttgaa agcctgaggc   2160

agctgggatg gtctttcttg tgtctcttct ttgcacccca gagcatgata taagtggtcc   2220

taacagattc tggataatgg agaagccctc tgctggtttt cctggcattc catgtagaat   2280

aggtagagaa tatttaacca atgagcaaat aaatgttggc atgtttcatg aaaaaaaaaa   2340

aaaaaa                                                              2346


<210>  67
<211>  351
<212>  PRT
<213>  Homo sapiens

<400>  67


Met Ser Trp Asn Ile Ser His Pro Gln Leu Ser Asp Lys Leu Phe Gly 
1               5                   10                  15      


Lys Asn Gly Val Leu Glu Glu Gln Lys Ser Pro Gly Phe Lys Lys Arg 
            20                  25                  30          


Glu Thr Glu Val Tyr Val Gly Asn Leu Pro Leu Asp Ile Ser Lys Glu 
        35                  40                  45              


Glu Ile Leu Tyr Leu Leu Lys Asp Phe Asn Pro Leu Asp Val His Lys 
    50                  55                  60                  


Ile Gln Asn Gly Cys Lys Cys Phe Ala Phe Val Asp Leu Gly Ser Met 
65                  70                  75                  80  


Gln Lys Val Thr Leu Ala Ile Gln Glu Leu Asn Gly Lys Leu Phe His 
                85                  90                  95      


Lys Arg Lys Leu Phe Val Asn Thr Ser Lys Arg Pro Pro Lys Arg Thr 
            100                 105                 110         


Pro Asp Met Ile Gln Gln Pro Arg Ala Pro Leu Val Leu Glu Lys Ala 
        115                 120                 125             


Ser Gly Glu Gly Phe Gly Lys Thr Ala Ala Ile Ile Gln Leu Ala Pro 
    130                 135                 140                 


Lys Ala Pro Val Asp Leu Cys Glu Thr Glu Lys Leu Arg Ala Ala Phe 
145                 150                 155                 160 


Phe Ala Val Pro Leu Glu Met Arg Gly Ser Phe Leu Val Leu Leu Leu 
                165                 170                 175     


Arg Glu Cys Phe Arg Asp Leu Ser Trp Leu Ala Leu Ile His Ser Val 
            180                 185                 190         


Arg Gly Glu Ala Gly Leu Leu Val Thr Ser Ile Val Pro Lys Thr Pro 
        195                 200                 205             


Phe Phe Trp Ala Met His Val Thr Glu Ala Leu His Gln Asn Met Gln 
    210                 215                 220                 


Ala Leu Phe Ser Thr Leu Ala Gln Ala Glu Glu Gln Gln Pro Tyr Leu 
225                 230                 235                 240 


Glu Gly Ser Thr Val Met Arg Gly Thr Arg Cys Leu Ala Glu Tyr His 
                245                 250                 255     


Leu Gly Asp Tyr Gly His Ala Trp Asn Arg Cys Trp Val Leu Asp Arg 
            260                 265                 270         


Val Asp Thr Trp Ala Val Val Met Phe Ile Asp Phe Gly Gln Leu Ala 
        275                 280                 285             


Thr Ile Pro Val Gln Ser Leu Arg Ser Leu Asp Ser Asp Asp Phe Trp 
    290                 295                 300                 


Thr Ile Pro Pro Leu Thr Gln Pro Phe Met Leu Glu Lys Asp Ile Leu 
305                 310                 315                 320 


Ser Ser Tyr Glu Val Val His Arg Ile Leu Lys Gly Lys Ile Thr Gly 
                325                 330                 335     


Ala Leu Asn Ser Ala Leu His Ile Leu Lys Phe Glu Glu Ser Lys 
            340                 345                 350     

<210>  68
<211>  3223
<212>  DNA
<213>  Homo sapiens

<400>  68
cggcggcggc ggcggcggcg gcggcggcgg agcccggagc gcaggccgga ggctcccggc     60

ccgccggccc cggagcggag cggagcggag gatgcagcag ccgcagccgc aggggcagca    120

gcagccgggg ccggggcagc agctgggggg ccagggggcg gcgccggggg ccgggggcgg    180

cccagggggg ggcccggggc cggggccctg cctgaggcga gagctgaagc tgctcgagtc    240

catcttccac cgcggccacg agcgcttccg cattgccagc gcctgcctgg acgagctgag    300

ctgcgagttc ctgctggctg gggccggagg ggccggggcg ggggccgcgc ccggaccgca    360

tctcccccca cgggggtcgg tgcctgggga tcctgtccgc atccactgca acatcacgga    420

gtcataccct gctgtgcccc ccatctggtc ggtggagtct gatgacccta acttggctgc    480

tgtcttggag aggctggtgg acataaagaa agggaatact ctgctattgc agcatctgaa    540

gaggatcatc tccgacctgt gtaaactcta taacctccct cagcatccag atgtggagat    600

gctggatcaa cccttgccag cagagcagtg cacacaggaa gacgtgtctt cagaagatga    660

agatgaggag atgcctgagg acacagaaga cttagatcac tatgaaatga aagaggaaga    720

gccagctgag ggcaagaaat ctgaagatga tggcattgga aaagaaaact tggccatcct    780

agagaaaatt aaaaagaacc agaggcaaga ttacttaaat ggtgcagtgt ctggctcggt    840

gcaggccact gaccggctga tgaaggagct cagggatata taccgatcac agagtttcaa    900

aggcggaaac tatgcagtcg aactcgtgaa tgacagtctg tatgattgga atgtcaaact    960

cctcaaagtt gaccaggaca gcgctttgca caacgatctc cagatcctca aagagaaaga   1020

aggagccgac ttcattctac ttaacttttc ctttaaagat aactttccct ttgacccacc   1080

atttgtcagg gttgtgtctc cagtcctctc tggagggtat gttctgggcg gaggggccat   1140

ctgcatggaa cttctcacca aacagggctg gagcagtgcc tactccatag agtcagtgat   1200

catgcagatc agtgccacac tggtgaaggg gaaagcacga gtgcagtttg gagccaacaa   1260

atctcaatac agtctgacaa gagcacagca gtcctacaag tccttggtgc agatccacga   1320

aaaaaacggc tggtacacac ccccaaaaga agacggctaa ccctggagta tcacccttcc   1380

tccctcccca ggcaccactg gaccaattac ctttgaatgc tgtatttgga tctcacgctg   1440

cctctgtggt tccctccctc atttttcctg gacgtgatag ctctgcctat tgcaggacaa   1500

tgatggctat tctaaacgct aaggaaaaaa aacaaacaca gaactgtttc aagtactcaa   1560

gactgactta cagaccaacc aaccaccttg ctggaaccct tgctagcagg cattcttata   1620

aaagaaactt tcgagcctcc ttatattgct ggaaactcag ctgtgctcca gactagagcc   1680

tccttaccta tgctatggat ttttaattta ttttctctta tttcatgtac actgcttttt   1740

ttggttacag tgtatgatgg atgtgtatga aaaaaatgta tctttgggaa aacaattaca   1800

gtttgttaat ttgaagatgc tggtcttgac tcatctttat ttttattcgc acatcccacc   1860

ccatcccctg aactacttgg gaggtgggga ggggtacgag tccactgttg ctttggtaga   1920

gatgagaggc cgcattttgc tgctaaagca agagaaactt ggagctgaag cacacacctg   1980

gtctgcccct agatttctcc tcaaggcctc tggagcaacc agcacttgcc cccttggaat   2040

gcagagcctg gcctgccaaa ctacaatgtg gtaggctgaa acgatggtgt taattcttag   2100

gactactttt ctagtcacag atgttttcaa atttctaaga aaaagaaaat gaggctcaag   2160

aggctgcttc gtagaattcc ttttgaatga attgagtggg gatggggaca cagtctccaa   2220

gtgtgtatgt ggtcttttct gatctcagct gtgtggctgc aactcttcgc tgttcattgg   2280

ttcctctcct ggaaagtggc ttctaaccag cactggatgg tgatcattgg taagctttgc   2340

tcacctccct ctctcttgct tcatttggct ttatcaaaaa gaacagacct agctctgaat   2400

ttgtttggct tgggaaatta tggattcttt caagccactc ccacaaggtg ggtcctacta   2460

gaaagggtta gcattttaag gggggttgtt ctatacacct gtgtccttac cccaggctca   2520

ggaactgcca gggagggaag atgaggtggg gagtctgtac tgagatggaa ctgtcagtgc   2580

tgtgttgtat gtacttgctg ttgtaaaagt ttgggcatga ctttgcatct agcgggtgct   2640

gcctgcatct ctttgtctgt aagcttgctc tgggactcag cctcttagga cctacgatgc   2700

cagcagctct cattaacagt gaaatgacag aggccaaaga tggccaagtg aagacccaag   2760

tctcagaaaa cccagacttg ggacaactgc ctgggaacta ggatgctaga gcagttctgt   2820

aatgctttga gacacagcaa ttttcacatt ggccattctt tcccctcccc tacccctttt   2880

cttttgaggg acttttaatg tttgctgctt taggtggatg gagagtccac cagtcccact   2940

caatgctgct ctaactctac ccacacccac ctaattaggg gtgctaataa aacatgctga   3000

ggttgagata aagacgggac ataaggggaa aattcattcc atagagctga aatctggttt   3060

tcaaggcctc tgtggctttc ttctgaactt accaccagcc ctggctggaa tgtagattgt   3120

gtttttagta atgtgtactg tgagctgtct tctgtataat gtattttgta atgtattttt   3180

ctcatctacc aaaggatgaa acaaataaaa ttatttaaat agt                     3223


<210>  69
<211>  422
<212>  PRT
<213>  Homo sapiens

<400>  69


Met Gln Gln Pro Gln Pro Gln Gly Gln Gln Gln Pro Gly Pro Gly Gln 
1               5                   10                  15      


Gln Leu Gly Gly Gln Gly Ala Ala Pro Gly Ala Gly Gly Gly Pro Gly 
            20                  25                  30          


Gly Gly Pro Gly Pro Gly Pro Cys Leu Arg Arg Glu Leu Lys Leu Leu 
        35                  40                  45              


Glu Ser Ile Phe His Arg Gly His Glu Arg Phe Arg Ile Ala Ser Ala 
    50                  55                  60                  


Cys Leu Asp Glu Leu Ser Cys Glu Phe Leu Leu Ala Gly Ala Gly Gly 
65                  70                  75                  80  


Ala Gly Ala Gly Ala Ala Pro Gly Pro His Leu Pro Pro Arg Gly Ser 
                85                  90                  95      


Val Pro Gly Asp Pro Val Arg Ile His Cys Asn Ile Thr Glu Ser Tyr 
            100                 105                 110         


Pro Ala Val Pro Pro Ile Trp Ser Val Glu Ser Asp Asp Pro Asn Leu 
        115                 120                 125             


Ala Ala Val Leu Glu Arg Leu Val Asp Ile Lys Lys Gly Asn Thr Leu 
    130                 135                 140                 


Leu Leu Gln His Leu Lys Arg Ile Ile Ser Asp Leu Cys Lys Leu Tyr 
145                 150                 155                 160 


Asn Leu Pro Gln His Pro Asp Val Glu Met Leu Asp Gln Pro Leu Pro 
                165                 170                 175     


Ala Glu Gln Cys Thr Gln Glu Asp Val Ser Ser Glu Asp Glu Asp Glu 
            180                 185                 190         


Glu Met Pro Glu Asp Thr Glu Asp Leu Asp His Tyr Glu Met Lys Glu 
        195                 200                 205             


Glu Glu Pro Ala Glu Gly Lys Lys Ser Glu Asp Asp Gly Ile Gly Lys 
    210                 215                 220                 


Glu Asn Leu Ala Ile Leu Glu Lys Ile Lys Lys Asn Gln Arg Gln Asp 
225                 230                 235                 240 


Tyr Leu Asn Gly Ala Val Ser Gly Ser Val Gln Ala Thr Asp Arg Leu 
                245                 250                 255     


Met Lys Glu Leu Arg Asp Ile Tyr Arg Ser Gln Ser Phe Lys Gly Gly 
            260                 265                 270         


Asn Tyr Ala Val Glu Leu Val Asn Asp Ser Leu Tyr Asp Trp Asn Val 
        275                 280                 285             


Lys Leu Leu Lys Val Asp Gln Asp Ser Ala Leu His Asn Asp Leu Gln 
    290                 295                 300                 


Ile Leu Lys Glu Lys Glu Gly Ala Asp Phe Ile Leu Leu Asn Phe Ser 
305                 310                 315                 320 


Phe Lys Asp Asn Phe Pro Phe Asp Pro Pro Phe Val Arg Val Val Ser 
                325                 330                 335     


Pro Val Leu Ser Gly Gly Tyr Val Leu Gly Gly Gly Ala Ile Cys Met 
            340                 345                 350         


Glu Leu Leu Thr Lys Gln Gly Trp Ser Ser Ala Tyr Ser Ile Glu Ser 
        355                 360                 365             


Val Ile Met Gln Ile Ser Ala Thr Leu Val Lys Gly Lys Ala Arg Val 
    370                 375                 380                 


Gln Phe Gly Ala Asn Lys Ser Gln Tyr Ser Leu Thr Arg Ala Gln Gln 
385                 390                 395                 400 


Ser Tyr Lys Ser Leu Val Gln Ile His Glu Lys Asn Gly Trp Tyr Thr 
                405                 410                 415     


Pro Pro Lys Glu Asp Gly 
            420         

<210>  70
<211>  5731
<212>  DNA
<213>  Homo sapiens

<400>  70
ctcctccccc tcaccgtccc aattgtattc cctggaagag cagccggaaa agcctccgcc     60

tgctcatacc aggataggca agaagctggt ttctcctcgc agccggctcc ctgaggccca    120

ggaaccaccg cggcggccgg caccacctgg acccagctcc aggcgggcgc ggcttcagca    180

ccacggacag cgccccaccc gcggccctcc ccccggcggc gcgctccagc cggtgtaggc    240

gaggcagcga gctatgcccg cggcatggcc cggcgctgcg gccccgtggc gctgctcctt    300

ggcttcggcc tcctccggct gtgctcaggg gtgtggggta cggatacaga ggagcggctg    360

gtggagcatc tcctggatcc ttcccgctac aacaagctta tccgcccagc caccaatggc    420

tctgagctgg tgacagtaca gcttatggtg tcactggccc agctcatcag tgtgcatgag    480

cgggagcaga tcatgaccac caatgtctgg ctgacccagg agtgggaaga ttatcgcctc    540

acctggaagc ctgaagagtt tgacaacatg aagaaagttc ggctcccttc caaacacatc    600

tggctcccag atgtggtcct gtacaacaat gctgacggca tgtacgaggt gtccttctat    660

tccaatgccg tggtctccta tgatggcagc atcttctggc tgccgcctgc catctacaag    720

agcgcatgca agattgaagt aaagcacttc ccatttgacc agcagaactg caccatgaag    780

ttccgttcgt ggacctacga ccgcacagag atcgacttgg tgctgaagag tgaggtggcc    840

agcctggacg acttcacacc tagtggtgag tgggacatcg tggcgctgcc gggccggcgc    900

aacgagaacc ccgacgactc tacgtacgtg gacatcacgt atgacttcat cattcgccgc    960

aagccgctct tctacaccat caacctcatc atcccctgtg tgctcatcac ctcgctagcc   1020

atccttgtct tctacctgcc atccgactgt ggcgagaaga tgacgttgtg catctcagtg   1080

ctgctggcgc tcacggtctt cctgctgctc atctccaaga tcgtgcctcc cacctccctc   1140

gacgtgccgc tcgtcggcaa gtacctcatg ttcaccatgg tgcttgtcac cttctccatc   1200

gtcaccagcg tgtgcgtgct caacgtgcac caccgctcgc ccaccacgca caccatggcg   1260

ccctgggtga aggtcgtctt cctggagaag ctgcccgcgc tgctcttcat gcagcagcca   1320

cgccatcatt gcgcccgtca gcgcctgcgc ctgcggcgac gccagcgtga gcgcgagggc   1380

gctggagccc tcttcttccg cgaagcccca ggggccgact cctgcacgtg cttcgtcaac   1440

cgcgcgtcgg tgcaggggtt ggccggggcc ttcggggctg agcctgcacc agtggcgggc   1500

cccgggcgct caggggagcc gtgtggctgt ggcctccggg aggcggtgga cggcgtgcgc   1560

ttcatcgcag accacatgcg gagcgaggac gatgaccaga gcgtgagtga ggactggaag   1620

tacgtcgcca tggtgatcga ccgcctcttc ctctggatct ttgtctttgt ctgtgtcttt   1680

ggcaccatcg gcatgttcct gcagcctctc ttccagaact acaccaccac caccttcctc   1740

cactcagacc actcagcccc cagctccaag tgaggccctt cctcatctcc atgctctttc   1800

accctgccac cctctgctgc acagtagtgt tgggtggagg atggacgagt gagctaccag   1860

gaagaggggc gctgccccca cagatccatc cttttgcttc atctggagtc cctcctcccc   1920

cacgcctcca tccacacaca gcagctccaa cctggaggct ggaccaactg ctttgttttg   1980

gctgctctcc atctcttgta ccagcccagg caatagtgtt gaggagggga gcaaggctgc   2040

taagtggaag acagagatgg cagagccatc caccctgagg agtgatgggc aaggggccag   2100

gaaggggaca ggattgtctg ctgcctccaa gtcatgggag aagaggggta taggacaagg   2160

ggtggaaggg caggagctca caccgcaccg ggctggcctg acacaatggt agctctgaag   2220

ggaggggaag agagaggcct gggtgtgacc tgacacctgc cgctgcttga gtggacagca   2280

gctggactgg gtgggcccca cagtggtcag cgattcctgc caagtagggt ttagccgggc   2340

cccatggtca cagacccctg ggggaggctt ccagctcagt cccacagccc cttgcttcta   2400

agggatccag agacctgctc cagatcctct ttccccactg aagaattctg caccctctgg   2460

acttccctct tcttccttcc tttctcaggc tcaaggtgtg gggggcaagg ctgagtatta   2520

ggggagcttc tgagttctga atctttgggt gacctgcttg gagtctcagg tccaaatact   2580

tgaaatctgt gagaagtcca agttcatggg cttttggaac tggaagaact ttgtacagcc   2640

atggattcca acataagcca tgttgcagat gaagaaactg acccacacgg tgagacaagc   2700

acaggtgggt ctgactcttc ctccctgccc tgagatccat ctgtcgagtg ccctgttttt   2760

tccccacttt gaactgactg gttactctaa ggaagtgaac tgaggatgtt agctttaagc   2820

caacccagcc tctttgtcca cagcagagct gaggtgaaca gctggaaccc tgctacatcc   2880

gtgctgctcc agtctgttct gctcatggct ccatccttct ggctgtcact cttcctcttc   2940

cccttcccaa ccaaacctga gcagctttga agcagaactt gggaaggaca gggctgctgc   3000

tgccagcgac acctcagaaa gcatagcctc ggcttcctgc cccatgtgtc cctggaagct   3060

gtaccctgac tctgcttcca gaggccagca gatggtgggt tacagacggg tcagcctgcc   3120

aagtgcacct gagggacctg acctgacaca agccattttg tccctagagc ccagctggga   3180

ctcctgcttc tctaggcagg gcagagggag gagacacagc acaggcacag agcatgggac   3240

agggaccccc gagtctggat tcaagtcctg gccctgctag taactcatgt gagccagctt   3300

gagcaagtcc cttcatcttg ctagagctca gcttccttgc ctataaaacg taggtggcaa   3360

tgccctcttc ctgaggttgc tgggaggata aggcagtgct tgtgaaaaag tctagcgctg   3420

tacctggcac agagtagatg cttcatgaat gttgagtctg acaggcaact ggagctggtg   3480

agaatggggt cccctgactg tcatgccagc ctccctccca ggcccactct tcccccctct   3540

tccctgagga aaccaagtct cccttatcag gaagagctgg gggagctggg aggaacatta   3600

caggaacacc agagggagtc tagcgggtgg gcaggcttct ctctgcagcc ccctcagcag   3660

tttcattcca ttcctgggct gaacccttgc cctggccctg cctcccttct gggtcagcac   3720

ctcctgacac aggtgtgtgc tcagggaccc caggctctag tcctgtactg gctgtggaag   3780

cctatcactg ggacaggaag ccagtggctg caggagacag gcctcagcgc atctcgtctg   3840

tcaggatggg ctcacggaca ccttttcttg gtagcaggga gtgtctctgc actatggaaa   3900

ctttccctct tctagagcgg attgggagtt gcctgtatta tgcctgaacc ctccttgaac   3960

tcatggtcct ggggaaggcg tcttggaacc agaaacagca acaggaaagg agcctccctc   4020

tgaagggtag gatgccggcc tgaggccctc cctcttggct ctcccagggc ctgggctacc   4080

ccgaggcccc agcagctgct gctgtggctg tacttgcttt taatatttcc catacatggc   4140

tgttgtccaa gttaagtcac caaatggtgc tagaggggat ggcagagagc agcttgtcca   4200

gctcctctcc atgacccggt taacacacga gtaaacaggc ctagagcttg tctgctgttt   4260

gacctctttt aagacccggc tgtgctgcat ctacaaaatg aagatgacag agctagccga   4320

ggtcttcagc aaggaagaaa ggggtcagtg tatatgaaag ggttacctgg gcagtgtcat   4380

tccctccatc tctgtacgca gccctttggg aaccatcaca ataaggaaga ggtgagggca   4440

gaggtgaagg atccactgcc caggcaaggt gctaccatgt ggtgggagag tgtgaaccct   4500

caagtgcact gggaagcttt ggggaaccac agtctcttcc acccttgggt cgtgtgtcgt   4560

cctcttctct tgatgtcagg gaagccccta tgcctccttc ccgtggtggg gctatctctg   4620

cagagaatcg ggtgcccagc ttaatgctgg gcaaggactg gaggaagctc cagatctgga   4680

ggtggcagag atactggatg gaaacctgga gcaagggttt gggaggggaa gtgaggaaac   4740

aggttgagac tatctccatc agagatggca aggccacagg tgatctgaga actatttttg   4800

tctgaaaaga aggcatgcac aggctctctg cttttgacag gtggcgttgc agtgggagga   4860

aggcagcttc ctggcgggga gatagaaata ctagaacagc tggtaccaag ttattgaaaa   4920

tttaaaagca aacaagacac agcagccccc aggtggtgtg ttctactgag gaaggctacg   4980

gcagaggaag ggcaagaccg tttcccccaa tggtcttgaa acggaagagg aaacagggag   5040

ggctctttgg atggtttggg gacctggggc tgtttgtatc ccagtattag ctcctgttac   5100

taagggtctg ctctgcgcca ggtcctcagc atgcgttgtc tttattccgc gtgacaatcc   5160

tatgggaagg ggcctccacc tacgtaacag aaatgcggct cagaaagacc aagtgacagc   5220

tagtgagtag tgctgggcct gaaccccaaa gtccacactc ttgctatagc cgctgaggca   5280

ggcagaagag ctccttggga ggaaagtaag gggcattcaa agccttctct gaatcactcc   5340

ccaagccaga gtagacctgg ttccagttgt cccccccttg tttccgggca gagtcaggca   5400

ggtgtcatac catccctccc cgcccaacca gtgctggcca gactcccatt caccgacctt   5460

gactagacag cgaacagcca ccttttagta ttcatcccaa caggtccagg cggtcagtgt   5520

gatagccacg cagttcctaa gggactgtag gtctaggaat cattaggaca ctcactcagc   5580

caccctcgat gcccccatct tccccacact gcccttggcc tccccgctct gcacgcctgg   5640

agtatttgca ctggtctagc ctactccagg tcagactcat taggaactca agattctcgt   5700

aaagaaagtt gtttccaaaa aaaaaaaaaa a                                  5731


<210>  71
<211>  502
<212>  PRT
<213>  Homo sapiens

<400>  71


Met Ala Arg Arg Cys Gly Pro Val Ala Leu Leu Leu Gly Phe Gly Leu 
1               5                   10                  15      


Leu Arg Leu Cys Ser Gly Val Trp Gly Thr Asp Thr Glu Glu Arg Leu 
            20                  25                  30          


Val Glu His Leu Leu Asp Pro Ser Arg Tyr Asn Lys Leu Ile Arg Pro 
        35                  40                  45              


Ala Thr Asn Gly Ser Glu Leu Val Thr Val Gln Leu Met Val Ser Leu 
    50                  55                  60                  


Ala Gln Leu Ile Ser Val His Glu Arg Glu Gln Ile Met Thr Thr Asn 
65                  70                  75                  80  


Val Trp Leu Thr Gln Glu Trp Glu Asp Tyr Arg Leu Thr Trp Lys Pro 
                85                  90                  95      


Glu Glu Phe Asp Asn Met Lys Lys Val Arg Leu Pro Ser Lys His Ile 
            100                 105                 110         


Trp Leu Pro Asp Val Val Leu Tyr Asn Asn Ala Asp Gly Met Tyr Glu 
        115                 120                 125             


Val Ser Phe Tyr Ser Asn Ala Val Val Ser Tyr Asp Gly Ser Ile Phe 
    130                 135                 140                 


Trp Leu Pro Pro Ala Ile Tyr Lys Ser Ala Cys Lys Ile Glu Val Lys 
145                 150                 155                 160 


His Phe Pro Phe Asp Gln Gln Asn Cys Thr Met Lys Phe Arg Ser Trp 
                165                 170                 175     


Thr Tyr Asp Arg Thr Glu Ile Asp Leu Val Leu Lys Ser Glu Val Ala 
            180                 185                 190         


Ser Leu Asp Asp Phe Thr Pro Ser Gly Glu Trp Asp Ile Val Ala Leu 
        195                 200                 205             


Pro Gly Arg Arg Asn Glu Asn Pro Asp Asp Ser Thr Tyr Val Asp Ile 
    210                 215                 220                 


Thr Tyr Asp Phe Ile Ile Arg Arg Lys Pro Leu Phe Tyr Thr Ile Asn 
225                 230                 235                 240 


Leu Ile Ile Pro Cys Val Leu Ile Thr Ser Leu Ala Ile Leu Val Phe 
                245                 250                 255     


Tyr Leu Pro Ser Asp Cys Gly Glu Lys Met Thr Leu Cys Ile Ser Val 
            260                 265                 270         


Leu Leu Ala Leu Thr Val Phe Leu Leu Leu Ile Ser Lys Ile Val Pro 
        275                 280                 285             


Pro Thr Ser Leu Asp Val Pro Leu Val Gly Lys Tyr Leu Met Phe Thr 
    290                 295                 300                 


Met Val Leu Val Thr Phe Ser Ile Val Thr Ser Val Cys Val Leu Asn 
305                 310                 315                 320 


Val His His Arg Ser Pro Thr Thr His Thr Met Ala Pro Trp Val Lys 
                325                 330                 335     


Val Val Phe Leu Glu Lys Leu Pro Ala Leu Leu Phe Met Gln Gln Pro 
            340                 345                 350         


Arg His His Cys Ala Arg Gln Arg Leu Arg Leu Arg Arg Arg Gln Arg 
        355                 360                 365             


Glu Arg Glu Gly Ala Gly Ala Leu Phe Phe Arg Glu Ala Pro Gly Ala 
    370                 375                 380                 


Asp Ser Cys Thr Cys Phe Val Asn Arg Ala Ser Val Gln Gly Leu Ala 
385                 390                 395                 400 


Gly Ala Phe Gly Ala Glu Pro Ala Pro Val Ala Gly Pro Gly Arg Ser 
                405                 410                 415     


Gly Glu Pro Cys Gly Cys Gly Leu Arg Glu Ala Val Asp Gly Val Arg 
            420                 425                 430         


Phe Ile Ala Asp His Met Arg Ser Glu Asp Asp Asp Gln Ser Val Ser 
        435                 440                 445             


Glu Asp Trp Lys Tyr Val Ala Met Val Ile Asp Arg Leu Phe Leu Trp 
    450                 455                 460                 


Ile Phe Val Phe Val Cys Val Phe Gly Thr Ile Gly Met Phe Leu Gln 
465                 470                 475                 480 


Pro Leu Phe Gln Asn Tyr Thr Thr Thr Thr Phe Leu His Ser Asp His 
                485                 490                 495     


Ser Ala Pro Ser Ser Lys 
            500         

<210>  72
<211>  6532
<212>  DNA
<213>  Homo sapiens

<400>  72
gactgaaggt agagaaggct acgtggtggg ggagggtggg gggagggtcg cggccgcact     60

ggcagcctcc gggtgtccgg ccgtgtcccg aggaagtgca agacccgggg tattccctca    120

gcggatacta cacccatcca tttcaaggct atgagcacag acagctcagg taccagcagc    180

ctgggccagg atcttccccc agtagtttcc tgcttaagca aatagaattt ctcaaggggc    240

agctcccaga agcaccggtg attggaaagc agacaccgtc actgccacct tccctcccag    300

gactccggcc aaggtttcca gtactacttg cctccagtac cagaggcagg caagtggaca    360

tcaggggtgt ccccaggggc gtgcatctcg gaagtcaggg gctccagaga gggttccagc    420

atccttcacc acgtggcagg agtctgccac agagaggtgt tgattgcctt tcctcacatt    480

tccaggaact gagtatctac caagatcagg aacaaaggat cttaaagttc ctggaagagc    540

ttggggaagg gaaggccacc acagcacatg atctgtctgg gaaacttggg actccgaaga    600

aagaaatcaa tcgagtttta tactccctgg caaagaaggg caagctacag aaagaggcag    660

gaacaccccc tttgtggaaa atcgcggtct ccactcaggc ttggaaccag cacagcggag    720

tggtaagacc agacggtcat agccaaggag ccccaaactc agacccgagt ttggaaccgg    780

aagacagaaa ctccacatct gtctcagaag atcttcttga gccttttatt gcagtctcag    840

ctcaggcttg gaaccagcac agcggagtgg taagaccaga cagtcatagc caaggatccc    900

caaactcaga cccaggtttg gaacctgaag acagcaactc cacatctgcc ttggaagatc    960

ctcttgagtt tttagacatg gccgagatca aggagaaaat ctgcgactat ctcttcaatg   1020

tgtctgactc ctctgccctg aatttggcta aaaatattgg ccttaccaag gcccgagata   1080

taaatgctgt gctaattgac atggaaaggc agggggatgt ctatagacaa gggacaaccc   1140

ctcccatatg gcatttgaca gacaagaagc gagagaggat gcaaatcaag agaaatacga   1200

acagtgttcc tgaaaccgct ccagctgcaa tccctgagac caaaagaaac gcagagttcc   1260

tcacctgtaa tatacccaca tcaaatgcct caaataacat ggtaaccaca gaaaaagtgg   1320

agaatgggca ggaacctgtc ataaagttag aaaacaggca agaggccaga ccagaaccag   1380

caagactgaa accacctgtt cattacaatg gcccctcaaa agcagggtat gttgactttg   1440

aaaatggcca gtgggccaca gatgacatcc cagatgactt gaatagtatc cgcgcagcac   1500

caggtgagtt tcgagccatc atggagatgc cctccttcta cagtcatggc ttgccacggt   1560

gttcacccta caagaaactg acagagtgcc agctgaagaa ccccatcagc gggctgttag   1620

aatatgccca gttcgctagt caaacctgtg agttcaacat gatagagcag agtggaccac   1680

cccatgaacc tcgatttaaa ttccaggttg tcatcaatgg ccgagagttt cccccagctg   1740

aagctggaag caagaaagtg gccaagcagg atgcagctat gaaagccatg acaattctgc   1800

tagaggaagc caaagccaag gacagtggaa aatcagaaga atcatcccac tattccacag   1860

agaaagaatc agagaagact gcagagtccc agacccccac cccttcagcc acatccttct   1920

tttctgggaa gagccccgtc accacactgc ttgagtgtat gcacaaattg gggaactcct   1980

gcgaattccg tctcctgtcc aaagaaggcc ctgcccatga acccaagttc caatactgtg   2040

ttgcagtggg agcccaaact ttccccagtg tgagtgctcc cagcaagaaa gtggcaaagc   2100

agatggccgc agaggaagcc atgaaggccc tgcatgggga ggcgaccaac tccatggctt   2160

ctgataacca gcctgaaggt atgatctcag agtcacttga taacttggaa tccatgatgc   2220

ccaacaaggt caggaagatt ggcgagctcg tgagatacct gaacaccaac cctgtgggtg   2280

gccttttgga gtacgcccgc tcccatggct ttgctgctga attcaagttg gtcgaccagt   2340

ccggacctcc tcacgagccc aagttcgttt accaagcaaa agttgggggt cgctggttcc   2400

cagccgtctg cgcacacagc aagaagcaag gcaagcagga agcagcagat gcggctctcc   2460

gtgtcttgat tggggagaac gagaaggcag aacgcatggg tttcacagag gtaaccccag   2520

tgacaggggc cagtctcaga agaactatgc tcctcctctc aaggtcccca gaagcacagc   2580

caaagacact ccctctcact ggcagcacct tccatgacca gatagccatg ctgagccacc   2640

ggtgcttcaa cactctgact aacagcttcc agccctcctt gctcggccgc aagattctgg   2700

ccgccatcat tatgaaaaaa gactctgagg acatgggtgt cgtcgtcagc ttgggaacag   2760

ggaatcgctg tgtgaaagga gattctctca gcctaaaagg agaaactgtc aatgactgcc   2820

atgcagaaat aatctcccgg agaggcttca tcaggtttct ctacagtgag ttaatgaaat   2880

acaactccca gactgcgaag gatagtatat ttgaacctgc taagggagga gaaaagctcc   2940

aaataaaaaa gactgtgtca ttccatctgt atatcagcac tgctccgtgt ggagatggcg   3000

ccctctttga caagtcctgc agcgaccgtg ctatggaaag cacagaatcc cgccactacc   3060

ctgtcttcga gaatcccaaa caaggaaagc tccgcaccaa ggtggagaac ggagaaggca   3120

caatccctgt ggaatccagt gacattgtgc ctacgtggga tggcattcgg ctcggggaga   3180

gactccgtac catgtcctgt agtgacaaaa tcctacgctg gaacgtgctg ggcctgcaag   3240

gggcactgtt gacccacttc ctgcagccca tttatctcaa atctgtcaca ttgggttacc   3300

ttttcagcca agggcatctg acccgtgcta tttgctgtcg tgtgacaaga gatgggagtg   3360

catttgagga tggactacga catcccttta ttgtcaacca ccccaaggtt ggcagagtca   3420

gcatatatga ttccaaaagg caatccggga agactaagga gacaagcgtc aactggtgtc   3480

tggctgatgg ctatgacctg gagatcctgg acggtaccag aggcactgtg gatgggccac   3540

ggaatgaatt gtcccgggtc tccaaaaaga acatttttct tctatttaag aagctctgct   3600

ccttccgtta ccgcagggat ctactgagac tctcctatgg tgaggccaag aaagctgccc   3660

gtgactacga gacggccaag aactacttca aaaaaggcct gaaggatatg ggctatggga   3720

actggattag caaaccccag gaggaaaaga acttttatct ctgcccagta tagtatgctc   3780

cagtgacaga tggattaggg tgtgtcatac tagggtgtga gagaggtagg tcgtagcatt   3840

cctcatcaca tggtcagggg attttttttt ctcctttttt tttcttttta agccataatt   3900

ggtgatactg aaaactttgg gttcccattt atcctgcttt ctttgggatt gctaggcaag   3960

gtctggccag gccccccttt tttcccccaa gtgaagaggc agaaacctaa gaagttatct   4020

tttctttcta cccaaagcat acatagtcac tgagcacctg cggtccattt cctcttaaaa   4080

gttttgtttt gatttgtttc catttccttt ccctttgtgt ttgctacact gacctcttgc   4140

ggtcttgatt aggtttcagt caactctgga tcatgtcagg gactgataat ttcatttgtg   4200

gattacgcag acccctctac ttcccctctt tcccttctga gattctttcc ttgtgatctg   4260

aatgtctcct tttccccctc agagggcaaa gaggtgaaca taaaggattt ggtgaaacat   4320

ttgtaagggt aggagttgaa aactgcagtt cccagtgcca cggaagtgtg attggagcct   4380

gcagataatg cccagccatc ctcccatcct gcactttagc cagctgcagg gcgggcaagg   4440

caaggaaagc tgcttccctg gaagtgtatc actttctccg gcagctggga agtctagaac   4500

cagccagact gggttaaggg agctgctcaa gcaatagcag aggtttcacc cggcaggatg   4560

acacagacca cttcccaggg agcacgggca tgccttggaa tattgccaag cttccagctg   4620

cctcttctcc taaagcattc ctaggaatat tttccccgcc aatgctgggc gtacacccta   4680

gccaacggga caaatcctag agggtataaa atcatctctg ctcagataat catgacttag   4740

caagaataag ggcaaaaaat cctgttggct taacgtcact gttccacccg gtgtaatatc   4800

tctcatgaca gtgacaccaa gggaagttga ctaagtcaca tgtaaattag gagtgtttta   4860

aagaatgcca tagatgttga ttcttaactg ctacagataa cctgtaattg agcagattta   4920

aaattcaggc atacttttcc atttatccaa gtgctttcat ttttccagat ggcttcagaa   4980

gtaggctcgt gggcagggcg cagacctgat ctttataggg ttgacataga aagcagtagt   5040

tgtgggtgaa agggcaggtt gtcttcaaac tctgtgaggt agaatccttt gtctatacct   5100

ccatgaacat tgactcgtgt gttcagagcc tttggcctct ctgtggagtc tggctctctg   5160

gctcctgtgc attctttgaa tagtcactcg taaaaactgt cagtgcttga aactgtttcc   5220

tttactcatg ttgaagggac tttgttggct tttagagtgt tggtcatgac tccaagagca   5280

gagcagggaa gagcccaagc atagacttgg tgccgtggtg atggctgcag tccagttttg   5340

tgatgctgct tttacgtgtc cctcgataac agtcagctag acacactcag gaggactact   5400

gaggctctgc gaccttcagg agctgagcct gcctctctcc tttagatgac agaccttcat   5460

ctgggaacgt gctgagccag caccctcaga tgatttccct ccaaactgct gactaggtca   5520

tcctctgtct ggtagagaca ttcacatctt tgcttttatt ctatgctctc tgtacttttg   5580

accaaaaatt gaccaaagta agaaaatgca agttctaaaa atagactaag gatgcctttg   5640

cagaacacca aagcatccca aggaactggt agggaagtgg cgcctgtctc ctggagtgga   5700

agaggcctgc tccctggctc tgggtctgct gggggcacag taaatcagtc ttggcaccca   5760

catccagggc agagaggtct gtggttctca gcatcagaag gcagcgcagc ccctctcctc   5820

ttcaggctac agggttgtca cctgctgagt cctcaggttg tttggcctct ctggtccatc   5880

ttgggcatta ggttctccag cagagctctg gccagctgcc tcttctttaa ctgggaacac   5940

aggctctcac aagatcagaa cccccactca cccccaagat cttatctagc aagcctgtag   6000

tattcagttt ctgttgtagg aagagagcga ggcatccctg aattccacgc atctgctgga   6060

aacgagccgt gtcagatcgc acatccctgc gcccccatgc ccctctgagt cacacaggac   6120

agaggaggca gagcttctgc ccactgttat cttcactttc tttgtccagt cttttgtttt   6180

taataagcag tgaccctccc tactcttctt tttaatgatt tttgtagttg atttgtctga   6240

actgtggcta ctgtgcattc cttgaataat cacttgtaaa aattgtcagt gcttgaagct   6300

gtttccttta ctcacattga agggacttcg ttggtttttt ggagtcttgg ttgtgactcc   6360

aagagcagag tgaggaagac ccccaagcat agactcgggt actgtgatga tggctgcagt   6420

ccagttttat gattctgctt ttatgtgtcc cttgataaca gtgacttaac aatatacatt   6480

cctcataaat aaaaaaaaaa caagaatctg aattcttaga aaaaaaaaaa aa           6532


<210>  73
<211>  931
<212>  PRT
<213>  Homo sapiens

<400>  73


Met Ala Glu Ile Lys Glu Lys Ile Cys Asp Tyr Leu Phe Asn Val Ser 
1               5                   10                  15      


Asp Ser Ser Ala Leu Asn Leu Ala Lys Asn Ile Gly Leu Thr Lys Ala 
            20                  25                  30          


Arg Asp Ile Asn Ala Val Leu Ile Asp Met Glu Arg Gln Gly Asp Val 
        35                  40                  45              


Tyr Arg Gln Gly Thr Thr Pro Pro Ile Trp His Leu Thr Asp Lys Lys 
    50                  55                  60                  


Arg Glu Arg Met Gln Ile Lys Arg Asn Thr Asn Ser Val Pro Glu Thr 
65                  70                  75                  80  


Ala Pro Ala Ala Ile Pro Glu Thr Lys Arg Asn Ala Glu Phe Leu Thr 
                85                  90                  95      


Cys Asn Ile Pro Thr Ser Asn Ala Ser Asn Asn Met Val Thr Thr Glu 
            100                 105                 110         


Lys Val Glu Asn Gly Gln Glu Pro Val Ile Lys Leu Glu Asn Arg Gln 
        115                 120                 125             


Glu Ala Arg Pro Glu Pro Ala Arg Leu Lys Pro Pro Val His Tyr Asn 
    130                 135                 140                 


Gly Pro Ser Lys Ala Gly Tyr Val Asp Phe Glu Asn Gly Gln Trp Ala 
145                 150                 155                 160 


Thr Asp Asp Ile Pro Asp Asp Leu Asn Ser Ile Arg Ala Ala Pro Gly 
                165                 170                 175     


Glu Phe Arg Ala Ile Met Glu Met Pro Ser Phe Tyr Ser His Gly Leu 
            180                 185                 190         


Pro Arg Cys Ser Pro Tyr Lys Lys Leu Thr Glu Cys Gln Leu Lys Asn 
        195                 200                 205             


Pro Ile Ser Gly Leu Leu Glu Tyr Ala Gln Phe Ala Ser Gln Thr Cys 
    210                 215                 220                 


Glu Phe Asn Met Ile Glu Gln Ser Gly Pro Pro His Glu Pro Arg Phe 
225                 230                 235                 240 


Lys Phe Gln Val Val Ile Asn Gly Arg Glu Phe Pro Pro Ala Glu Ala 
                245                 250                 255     


Gly Ser Lys Lys Val Ala Lys Gln Asp Ala Ala Met Lys Ala Met Thr 
            260                 265                 270         


Ile Leu Leu Glu Glu Ala Lys Ala Lys Asp Ser Gly Lys Ser Glu Glu 
        275                 280                 285             


Ser Ser His Tyr Ser Thr Glu Lys Glu Ser Glu Lys Thr Ala Glu Ser 
    290                 295                 300                 


Gln Thr Pro Thr Pro Ser Ala Thr Ser Phe Phe Ser Gly Lys Ser Pro 
305                 310                 315                 320 


Val Thr Thr Leu Leu Glu Cys Met His Lys Leu Gly Asn Ser Cys Glu 
                325                 330                 335     


Phe Arg Leu Leu Ser Lys Glu Gly Pro Ala His Glu Pro Lys Phe Gln 
            340                 345                 350         


Tyr Cys Val Ala Val Gly Ala Gln Thr Phe Pro Ser Val Ser Ala Pro 
        355                 360                 365             


Ser Lys Lys Val Ala Lys Gln Met Ala Ala Glu Glu Ala Met Lys Ala 
    370                 375                 380                 


Leu His Gly Glu Ala Thr Asn Ser Met Ala Ser Asp Asn Gln Pro Glu 
385                 390                 395                 400 


Gly Met Ile Ser Glu Ser Leu Asp Asn Leu Glu Ser Met Met Pro Asn 
                405                 410                 415     


Lys Val Arg Lys Ile Gly Glu Leu Val Arg Tyr Leu Asn Thr Asn Pro 
            420                 425                 430         


Val Gly Gly Leu Leu Glu Tyr Ala Arg Ser His Gly Phe Ala Ala Glu 
        435                 440                 445             


Phe Lys Leu Val Asp Gln Ser Gly Pro Pro His Glu Pro Lys Phe Val 
    450                 455                 460                 


Tyr Gln Ala Lys Val Gly Gly Arg Trp Phe Pro Ala Val Cys Ala His 
465                 470                 475                 480 


Ser Lys Lys Gln Gly Lys Gln Glu Ala Ala Asp Ala Ala Leu Arg Val 
                485                 490                 495     


Leu Ile Gly Glu Asn Glu Lys Ala Glu Arg Met Gly Phe Thr Glu Val 
            500                 505                 510         


Thr Pro Val Thr Gly Ala Ser Leu Arg Arg Thr Met Leu Leu Leu Ser 
        515                 520                 525             


Arg Ser Pro Glu Ala Gln Pro Lys Thr Leu Pro Leu Thr Gly Ser Thr 
    530                 535                 540                 


Phe His Asp Gln Ile Ala Met Leu Ser His Arg Cys Phe Asn Thr Leu 
545                 550                 555                 560 


Thr Asn Ser Phe Gln Pro Ser Leu Leu Gly Arg Lys Ile Leu Ala Ala 
                565                 570                 575     


Ile Ile Met Lys Lys Asp Ser Glu Asp Met Gly Val Val Val Ser Leu 
            580                 585                 590         


Gly Thr Gly Asn Arg Cys Val Lys Gly Asp Ser Leu Ser Leu Lys Gly 
        595                 600                 605             


Glu Thr Val Asn Asp Cys His Ala Glu Ile Ile Ser Arg Arg Gly Phe 
    610                 615                 620                 


Ile Arg Phe Leu Tyr Ser Glu Leu Met Lys Tyr Asn Ser Gln Thr Ala 
625                 630                 635                 640 


Lys Asp Ser Ile Phe Glu Pro Ala Lys Gly Gly Glu Lys Leu Gln Ile 
                645                 650                 655     


Lys Lys Thr Val Ser Phe His Leu Tyr Ile Ser Thr Ala Pro Cys Gly 
            660                 665                 670         


Asp Gly Ala Leu Phe Asp Lys Ser Cys Ser Asp Arg Ala Met Glu Ser 
        675                 680                 685             


Thr Glu Ser Arg His Tyr Pro Val Phe Glu Asn Pro Lys Gln Gly Lys 
    690                 695                 700                 


Leu Arg Thr Lys Val Glu Asn Gly Glu Gly Thr Ile Pro Val Glu Ser 
705                 710                 715                 720 


Ser Asp Ile Val Pro Thr Trp Asp Gly Ile Arg Leu Gly Glu Arg Leu 
                725                 730                 735     


Arg Thr Met Ser Cys Ser Asp Lys Ile Leu Arg Trp Asn Val Leu Gly 
            740                 745                 750         


Leu Gln Gly Ala Leu Leu Thr His Phe Leu Gln Pro Ile Tyr Leu Lys 
        755                 760                 765             


Ser Val Thr Leu Gly Tyr Leu Phe Ser Gln Gly His Leu Thr Arg Ala 
    770                 775                 780                 


Ile Cys Cys Arg Val Thr Arg Asp Gly Ser Ala Phe Glu Asp Gly Leu 
785                 790                 795                 800 


Arg His Pro Phe Ile Val Asn His Pro Lys Val Gly Arg Val Ser Ile 
                805                 810                 815     


Tyr Asp Ser Lys Arg Gln Ser Gly Lys Thr Lys Glu Thr Ser Val Asn 
            820                 825                 830         


Trp Cys Leu Ala Asp Gly Tyr Asp Leu Glu Ile Leu Asp Gly Thr Arg 
        835                 840                 845             


Gly Thr Val Asp Gly Pro Arg Asn Glu Leu Ser Arg Val Ser Lys Lys 
    850                 855                 860                 


Asn Ile Phe Leu Leu Phe Lys Lys Leu Cys Ser Phe Arg Tyr Arg Arg 
865                 870                 875                 880 


Asp Leu Leu Arg Leu Ser Tyr Gly Glu Ala Lys Lys Ala Ala Arg Asp 
                885                 890                 895     


Tyr Glu Thr Ala Lys Asn Tyr Phe Lys Lys Gly Leu Lys Asp Met Gly 
            900                 905                 910         


Tyr Gly Asn Trp Ile Ser Lys Pro Gln Glu Glu Lys Asn Phe Tyr Leu 
        915                 920                 925             


Cys Pro Val 
    930     

<210>  74
<211>  6640
<212>  DNA
<213>  Homo sapiens

<400>  74
gaggaaacga aagcgaaatt gaaccggagc catcttgggc ccggcgcgca gacccgcgga     60

gtttcccgtg ccgacgcccc ggggccactt ccagtgcgga gtagcggagg cgtgggggcc    120

tcgaggggct ggcgcggccc agcggtcggg ccagggtcgt gccgccggcg ggtcgggccg    180

ggcaatgcct cgcgggcgca atgaatccgc ggcaggggta ttccctcagc ggatactaca    240

cccatccatt tcaaggctat gagcacagac agctcaggta ccagcagcct gggccaggat    300

cttcccccag tagtttcctg cttaagcaaa tagaatttct caaggggcag ctcccagaag    360

caccggtgat tggaaagcag acaccgtcac tgccaccttc cctcccagga ctccggccaa    420

ggtttccagt actacttgcc tccagtacca gaggcaggca agtggacatc aggggtgtcc    480

ccaggggcgt gcatctcgga agtcaggggc tccagagagg gttccagcat ccttcaccac    540

gtggcaggag tctgccacag agaggtgttg attgcctttc ctcacatttc caggaactga    600

gtatctacca agatcaggaa caaaggatct taaagttcct ggaagagctt ggggaaggga    660

aggccaccac agcacatgat ctgtctggga aacttgggac tccgaagaaa gaaatcaatc    720

gagttttata ctccctggca aagaagggca agctacagaa agaggcagga acaccccctt    780

tgtggaaaat cgcggtctcc actcaggctt ggaaccagca cagcggagtg gtaagaccag    840

acggtcatag ccaaggagcc ccaaactcag acccgagttt ggaaccggaa gacagaaact    900

ccacatctgt ctcagaagat cttcttgagc cttttattgc agtctcagct caggcttgga    960

accagcacag cggagtggta agaccagaca gtcatagcca aggatcccca aactcagacc   1020

caggtttgga acctgaagac agcaactcca catctgcctt ggaagatcct cttgagtttt   1080

tagacatggc cgagatcaag gagaaaatct gcgactatct cttcaatgtg tctgactcct   1140

ctgccctgaa tttggctaaa aatattggcc ttaccaaggc ccgagatata aatgctgtgc   1200

taattgacat ggaaaggcag ggggatgtct atagacaagg gacaacccct cccatatggc   1260

atttgacaga caagaagcga gagaggatgc aaatcaagag aaatacgaac agtgttcctg   1320

aaaccgctcc agctgcaatc cctgagacca aaagaaacgc agagttcctc acctgtaata   1380

tacccacatc aaatgcctca aataacatgg taaccacaga aaaagtggag aatgggcagg   1440

aacctgtcat aaagttagaa aacaggcaag aggccagacc agaaccagca agactgaaac   1500

cacctgttca ttacaatggc ccctcaaaag cagggtatgt tgactttgaa aatggccagt   1560

gggccacaga tgacatccca gatgacttga atagtatccg cgcagcacca ggtgagtttc   1620

gagccatcat ggagatgccc tccttctaca gtcatggctt gccacggtgt tcaccctaca   1680

agaaactgac agagtgccag ctgaagaacc ccatcagcgg gctgttagaa tatgcccagt   1740

tcgctagtca aacctgtgag ttcaacatga tagagcagag tggaccaccc catgaacctc   1800

gatttaaatt ccaggttgtc atcaatggcc gagagtttcc cccagctgaa gctggaagca   1860

agaaagtggc caagcaggat gcagctatga aagccatgac aattctgcta gaggaagcca   1920

aagccaagga cagtggaaaa tcagaagaat catcccacta ttccacagag aaagaatcag   1980

agaagactgc agagtcccag acccccaccc cttcagccac atccttcttt tctgggaaga   2040

gccccgtcac cacactgctt gagtgtatgc acaaattggg gaactcctgc gaattccgtc   2100

tcctgtccaa agaaggccct gcccatgaac ccaagttcca atactgtgtt gcagtgggag   2160

cccaaacttt ccccagtgtg agtgctccca gcaagaaagt ggcaaagcag atggccgcag   2220

aggaagccat gaaggccctg catggggagg cgaccaactc catggcttct gataaccagc   2280

ctgaaggtat gatctcagag tcacttgata acttggaatc catgatgccc aacaaggtca   2340

ggaagattgg cgagctcgtg agatacctga acaccaaccc tgtgggtggc cttttggagt   2400

acgcccgctc ccatggcttt gctgctgaat tcaagttggt cgaccagtcc ggacctcctc   2460

acgagcccaa gttcgtttac caagcaaaag ttgggggtcg ctggttccca gccgtctgcg   2520

cacacagcaa gaagcaaggc aagcaggaag cagcagatgc ggctctccgt gtcttgattg   2580

gggagaacga gaaggcagaa cgcatgggtt tcacagaggt aaccccagtg acaggggcca   2640

gtctcagaag aactatgctc ctcctctcaa ggtccccaga agcacagcca aagacactcc   2700

ctctcactgg cagcaccttc catgaccaga tagccatgct gagccaccgg tgcttcaaca   2760

ctctgactaa cagcttccag ccctccttgc tcggccgcaa gattctggcc gccatcatta   2820

tgaaaaaaga ctctgaggac atgggtgtcg tcgtcagctt gggaacaggg aatcgctgtg   2880

tgaaaggaga ttctctcagc ctaaaaggag aaactgtcaa tgactgccat gcagaaataa   2940

tctcccggag aggcttcatc aggtttctct acagtgagtt aatgaaatac aactcccaga   3000

ctgcgaagga tagtatattt gaacctgcta agggaggaga aaagctccaa ataaaaaaga   3060

ctgtgtcatt ccatctgtat atcagcactg ctccgtgtgg agatggcgcc ctctttgaca   3120

agtcctgcag cgaccgtgct atggaaagca cagaatcccg ccactaccct gtcttcgaga   3180

atcccaaaca aggaaagctc cgcaccaagg tggagaacgg agaaggcaca atccctgtgg   3240

aatccagtga cattgtgcct acgtgggatg gcattcggct cggggagaga ctccgtacca   3300

tgtcctgtag tgacaaaatc ctacgctgga acgtgctggg cctgcaaggg gcactgttga   3360

cccacttcct gcagcccatt tatctcaaat ctgtcacatt gggttacctt ttcagccaag   3420

ggcatctgac ccgtgctatt tgctgtcgtg tgacaagaga tgggagtgca tttgaggatg   3480

gactacgaca tccctttatt gtcaaccacc ccaaggttgg cagagtcagc atatatgatt   3540

ccaaaaggca atccgggaag actaaggaga caagcgtcaa ctggtgtctg gctgatggct   3600

atgacctgga gatcctggac ggtaccagag gcactgtgga tgggccacgg aatgaattgt   3660

cccgggtctc caaaaagaac atttttcttc tatttaagaa gctctgctcc ttccgttacc   3720

gcagggatct actgagactc tcctatggtg aggccaagaa agctgcccgt gactacgaga   3780

cggccaagaa ctacttcaaa aaaggcctga aggatatggg ctatgggaac tggattagca   3840

aaccccagga ggaaaagaac ttttatctct gcccagtata gtatgctcca gtgacagatg   3900

gattagggtg tgtcatacta gggtgtgaga gaggtaggtc gtagcattcc tcatcacatg   3960

gtcaggggat ttttttttct cctttttttt tctttttaag ccataattgg tgatactgaa   4020

aactttgggt tcccatttat cctgctttct ttgggattgc taggcaaggt ctggccaggc   4080

cccccttttt tcccccaagt gaagaggcag aaacctaaga agttatcttt tctttctacc   4140

caaagcatac atagtcactg agcacctgcg gtccatttcc tcttaaaagt tttgttttga   4200

tttgtttcca tttcctttcc ctttgtgttt gctacactga cctcttgcgg tcttgattag   4260

gtttcagtca actctggatc atgtcaggga ctgataattt catttgtgga ttacgcagac   4320

ccctctactt cccctctttc ccttctgaga ttctttcctt gtgatctgaa tgtctccttt   4380

tccccctcag agggcaaaga ggtgaacata aaggatttgg tgaaacattt gtaagggtag   4440

gagttgaaaa ctgcagttcc cagtgccacg gaagtgtgat tggagcctgc agataatgcc   4500

cagccatcct cccatcctgc actttagcca gctgcagggc gggcaaggca aggaaagctg   4560

cttccctgga agtgtatcac tttctccggc agctgggaag tctagaacca gccagactgg   4620

gttaagggag ctgctcaagc aatagcagag gtttcacccg gcaggatgac acagaccact   4680

tcccagggag cacgggcatg ccttggaata ttgccaagct tccagctgcc tcttctccta   4740

aagcattcct aggaatattt tccccgccaa tgctgggcgt acaccctagc caacgggaca   4800

aatcctagag ggtataaaat catctctgct cagataatca tgacttagca agaataaggg   4860

caaaaaatcc tgttggctta acgtcactgt tccacccggt gtaatatctc tcatgacagt   4920

gacaccaagg gaagttgact aagtcacatg taaattagga gtgttttaaa gaatgccata   4980

gatgttgatt cttaactgct acagataacc tgtaattgag cagatttaaa attcaggcat   5040

acttttccat ttatccaagt gctttcattt ttccagatgg cttcagaagt aggctcgtgg   5100

gcagggcgca gacctgatct ttatagggtt gacatagaaa gcagtagttg tgggtgaaag   5160

ggcaggttgt cttcaaactc tgtgaggtag aatcctttgt ctatacctcc atgaacattg   5220

actcgtgtgt tcagagcctt tggcctctct gtggagtctg gctctctggc tcctgtgcat   5280

tctttgaata gtcactcgta aaaactgtca gtgcttgaaa ctgtttcctt tactcatgtt   5340

gaagggactt tgttggcttt tagagtgttg gtcatgactc caagagcaga gcagggaaga   5400

gcccaagcat agacttggtg ccgtggtgat ggctgcagtc cagttttgtg atgctgcttt   5460

tacgtgtccc tcgataacag tcagctagac acactcagga ggactactga ggctctgcga   5520

ccttcaggag ctgagcctgc ctctctcctt tagatgacag accttcatct gggaacgtgc   5580

tgagccagca ccctcagatg atttccctcc aaactgctga ctaggtcatc ctctgtctgg   5640

tagagacatt cacatctttg cttttattct atgctctctg tacttttgac caaaaattga   5700

ccaaagtaag aaaatgcaag ttctaaaaat agactaagga tgcctttgca gaacaccaaa   5760

gcatcccaag gaactggtag ggaagtggcg cctgtctcct ggagtggaag aggcctgctc   5820

cctggctctg ggtctgctgg gggcacagta aatcagtctt ggcacccaca tccagggcag   5880

agaggtctgt ggttctcagc atcagaaggc agcgcagccc ctctcctctt caggctacag   5940

ggttgtcacc tgctgagtcc tcaggttgtt tggcctctct ggtccatctt gggcattagg   6000

ttctccagca gagctctggc cagctgcctc ttctttaact gggaacacag gctctcacaa   6060

gatcagaacc cccactcacc cccaagatct tatctagcaa gcctgtagta ttcagtttct   6120

gttgtaggaa gagagcgagg catccctgaa ttccacgcat ctgctggaaa cgagccgtgt   6180

cagatcgcac atccctgcgc ccccatgccc ctctgagtca cacaggacag aggaggcaga   6240

gcttctgccc actgttatct tcactttctt tgtccagtct tttgttttta ataagcagtg   6300

accctcccta ctcttctttt taatgatttt tgtagttgat ttgtctgaac tgtggctact   6360

gtgcattcct tgaataatca cttgtaaaaa ttgtcagtgc ttgaagctgt ttcctttact   6420

cacattgaag ggacttcgtt ggttttttgg agtcttggtt gtgactccaa gagcagagtg   6480

aggaagaccc ccaagcatag actcgggtac tgtgatgatg gctgcagtcc agttttatga   6540

ttctgctttt atgtgtccct tgataacagt gacttaacaa tatacattcc tcataaataa   6600

aaaaaaaaca agaatctgaa ttcttagaaa aaaaaaaaaa                         6640


<210>  75
<211>  1226
<212>  PRT
<213>  Homo sapiens

<400>  75


Met Asn Pro Arg Gln Gly Tyr Ser Leu Ser Gly Tyr Tyr Thr His Pro 
1               5                   10                  15      


Phe Gln Gly Tyr Glu His Arg Gln Leu Arg Tyr Gln Gln Pro Gly Pro 
            20                  25                  30          


Gly Ser Ser Pro Ser Ser Phe Leu Leu Lys Gln Ile Glu Phe Leu Lys 
        35                  40                  45              


Gly Gln Leu Pro Glu Ala Pro Val Ile Gly Lys Gln Thr Pro Ser Leu 
    50                  55                  60                  


Pro Pro Ser Leu Pro Gly Leu Arg Pro Arg Phe Pro Val Leu Leu Ala 
65                  70                  75                  80  


Ser Ser Thr Arg Gly Arg Gln Val Asp Ile Arg Gly Val Pro Arg Gly 
                85                  90                  95      


Val His Leu Gly Ser Gln Gly Leu Gln Arg Gly Phe Gln His Pro Ser 
            100                 105                 110         


Pro Arg Gly Arg Ser Leu Pro Gln Arg Gly Val Asp Cys Leu Ser Ser 
        115                 120                 125             


His Phe Gln Glu Leu Ser Ile Tyr Gln Asp Gln Glu Gln Arg Ile Leu 
    130                 135                 140                 


Lys Phe Leu Glu Glu Leu Gly Glu Gly Lys Ala Thr Thr Ala His Asp 
145                 150                 155                 160 


Leu Ser Gly Lys Leu Gly Thr Pro Lys Lys Glu Ile Asn Arg Val Leu 
                165                 170                 175     


Tyr Ser Leu Ala Lys Lys Gly Lys Leu Gln Lys Glu Ala Gly Thr Pro 
            180                 185                 190         


Pro Leu Trp Lys Ile Ala Val Ser Thr Gln Ala Trp Asn Gln His Ser 
        195                 200                 205             


Gly Val Val Arg Pro Asp Gly His Ser Gln Gly Ala Pro Asn Ser Asp 
    210                 215                 220                 


Pro Ser Leu Glu Pro Glu Asp Arg Asn Ser Thr Ser Val Ser Glu Asp 
225                 230                 235                 240 


Leu Leu Glu Pro Phe Ile Ala Val Ser Ala Gln Ala Trp Asn Gln His 
                245                 250                 255     


Ser Gly Val Val Arg Pro Asp Ser His Ser Gln Gly Ser Pro Asn Ser 
            260                 265                 270         


Asp Pro Gly Leu Glu Pro Glu Asp Ser Asn Ser Thr Ser Ala Leu Glu 
        275                 280                 285             


Asp Pro Leu Glu Phe Leu Asp Met Ala Glu Ile Lys Glu Lys Ile Cys 
    290                 295                 300                 


Asp Tyr Leu Phe Asn Val Ser Asp Ser Ser Ala Leu Asn Leu Ala Lys 
305                 310                 315                 320 


Asn Ile Gly Leu Thr Lys Ala Arg Asp Ile Asn Ala Val Leu Ile Asp 
                325                 330                 335     


Met Glu Arg Gln Gly Asp Val Tyr Arg Gln Gly Thr Thr Pro Pro Ile 
            340                 345                 350         


Trp His Leu Thr Asp Lys Lys Arg Glu Arg Met Gln Ile Lys Arg Asn 
        355                 360                 365             


Thr Asn Ser Val Pro Glu Thr Ala Pro Ala Ala Ile Pro Glu Thr Lys 
    370                 375                 380                 


Arg Asn Ala Glu Phe Leu Thr Cys Asn Ile Pro Thr Ser Asn Ala Ser 
385                 390                 395                 400 


Asn Asn Met Val Thr Thr Glu Lys Val Glu Asn Gly Gln Glu Pro Val 
                405                 410                 415     


Ile Lys Leu Glu Asn Arg Gln Glu Ala Arg Pro Glu Pro Ala Arg Leu 
            420                 425                 430         


Lys Pro Pro Val His Tyr Asn Gly Pro Ser Lys Ala Gly Tyr Val Asp 
        435                 440                 445             


Phe Glu Asn Gly Gln Trp Ala Thr Asp Asp Ile Pro Asp Asp Leu Asn 
    450                 455                 460                 


Ser Ile Arg Ala Ala Pro Gly Glu Phe Arg Ala Ile Met Glu Met Pro 
465                 470                 475                 480 


Ser Phe Tyr Ser His Gly Leu Pro Arg Cys Ser Pro Tyr Lys Lys Leu 
                485                 490                 495     


Thr Glu Cys Gln Leu Lys Asn Pro Ile Ser Gly Leu Leu Glu Tyr Ala 
            500                 505                 510         


Gln Phe Ala Ser Gln Thr Cys Glu Phe Asn Met Ile Glu Gln Ser Gly 
        515                 520                 525             


Pro Pro His Glu Pro Arg Phe Lys Phe Gln Val Val Ile Asn Gly Arg 
    530                 535                 540                 


Glu Phe Pro Pro Ala Glu Ala Gly Ser Lys Lys Val Ala Lys Gln Asp 
545                 550                 555                 560 


Ala Ala Met Lys Ala Met Thr Ile Leu Leu Glu Glu Ala Lys Ala Lys 
                565                 570                 575     


Asp Ser Gly Lys Ser Glu Glu Ser Ser His Tyr Ser Thr Glu Lys Glu 
            580                 585                 590         


Ser Glu Lys Thr Ala Glu Ser Gln Thr Pro Thr Pro Ser Ala Thr Ser 
        595                 600                 605             


Phe Phe Ser Gly Lys Ser Pro Val Thr Thr Leu Leu Glu Cys Met His 
    610                 615                 620                 


Lys Leu Gly Asn Ser Cys Glu Phe Arg Leu Leu Ser Lys Glu Gly Pro 
625                 630                 635                 640 


Ala His Glu Pro Lys Phe Gln Tyr Cys Val Ala Val Gly Ala Gln Thr 
                645                 650                 655     


Phe Pro Ser Val Ser Ala Pro Ser Lys Lys Val Ala Lys Gln Met Ala 
            660                 665                 670         


Ala Glu Glu Ala Met Lys Ala Leu His Gly Glu Ala Thr Asn Ser Met 
        675                 680                 685             


Ala Ser Asp Asn Gln Pro Glu Gly Met Ile Ser Glu Ser Leu Asp Asn 
    690                 695                 700                 


Leu Glu Ser Met Met Pro Asn Lys Val Arg Lys Ile Gly Glu Leu Val 
705                 710                 715                 720 


Arg Tyr Leu Asn Thr Asn Pro Val Gly Gly Leu Leu Glu Tyr Ala Arg 
                725                 730                 735     


Ser His Gly Phe Ala Ala Glu Phe Lys Leu Val Asp Gln Ser Gly Pro 
            740                 745                 750         


Pro His Glu Pro Lys Phe Val Tyr Gln Ala Lys Val Gly Gly Arg Trp 
        755                 760                 765             


Phe Pro Ala Val Cys Ala His Ser Lys Lys Gln Gly Lys Gln Glu Ala 
    770                 775                 780                 


Ala Asp Ala Ala Leu Arg Val Leu Ile Gly Glu Asn Glu Lys Ala Glu 
785                 790                 795                 800 


Arg Met Gly Phe Thr Glu Val Thr Pro Val Thr Gly Ala Ser Leu Arg 
                805                 810                 815     


Arg Thr Met Leu Leu Leu Ser Arg Ser Pro Glu Ala Gln Pro Lys Thr 
            820                 825                 830         


Leu Pro Leu Thr Gly Ser Thr Phe His Asp Gln Ile Ala Met Leu Ser 
        835                 840                 845             


His Arg Cys Phe Asn Thr Leu Thr Asn Ser Phe Gln Pro Ser Leu Leu 
    850                 855                 860                 


Gly Arg Lys Ile Leu Ala Ala Ile Ile Met Lys Lys Asp Ser Glu Asp 
865                 870                 875                 880 


Met Gly Val Val Val Ser Leu Gly Thr Gly Asn Arg Cys Val Lys Gly 
                885                 890                 895     


Asp Ser Leu Ser Leu Lys Gly Glu Thr Val Asn Asp Cys His Ala Glu 
            900                 905                 910         


Ile Ile Ser Arg Arg Gly Phe Ile Arg Phe Leu Tyr Ser Glu Leu Met 
        915                 920                 925             


Lys Tyr Asn Ser Gln Thr Ala Lys Asp Ser Ile Phe Glu Pro Ala Lys 
    930                 935                 940                 


Gly Gly Glu Lys Leu Gln Ile Lys Lys Thr Val Ser Phe His Leu Tyr 
945                 950                 955                 960 


Ile Ser Thr Ala Pro Cys Gly Asp Gly Ala Leu Phe Asp Lys Ser Cys 
                965                 970                 975     


Ser Asp Arg Ala Met Glu Ser Thr Glu Ser Arg His Tyr Pro Val Phe 
            980                 985                 990         


Glu Asn Pro Lys Gln Gly Lys Leu  Arg Thr Lys Val Glu  Asn Gly Glu 
        995                 1000                 1005             


Gly Thr  Ile Pro Val Glu Ser  Ser Asp Ile Val Pro  Thr Trp Asp 
    1010                 1015                 1020             


Gly Ile  Arg Leu Gly Glu Arg  Leu Arg Thr Met Ser  Cys Ser Asp 
    1025                 1030                 1035             


Lys Ile  Leu Arg Trp Asn Val  Leu Gly Leu Gln Gly  Ala Leu Leu 
    1040                 1045                 1050             


Thr His  Phe Leu Gln Pro Ile  Tyr Leu Lys Ser Val  Thr Leu Gly 
    1055                 1060                 1065             


Tyr Leu  Phe Ser Gln Gly His  Leu Thr Arg Ala Ile  Cys Cys Arg 
    1070                 1075                 1080             


Val Thr  Arg Asp Gly Ser Ala  Phe Glu Asp Gly Leu  Arg His Pro 
    1085                 1090                 1095             


Phe Ile  Val Asn His Pro Lys  Val Gly Arg Val Ser  Ile Tyr Asp 
    1100                 1105                 1110             


Ser Lys  Arg Gln Ser Gly Lys  Thr Lys Glu Thr Ser  Val Asn Trp 
    1115                 1120                 1125             


Cys Leu  Ala Asp Gly Tyr Asp  Leu Glu Ile Leu Asp  Gly Thr Arg 
    1130                 1135                 1140             


Gly Thr  Val Asp Gly Pro Arg  Asn Glu Leu Ser Arg  Val Ser Lys 
    1145                 1150                 1155             


Lys Asn  Ile Phe Leu Leu Phe  Lys Lys Leu Cys Ser  Phe Arg Tyr 
    1160                 1165                 1170             


Arg Arg  Asp Leu Leu Arg Leu  Ser Tyr Gly Glu Ala  Lys Lys Ala 
    1175                 1180                 1185             


Ala Arg  Asp Tyr Glu Thr Ala  Lys Asn Tyr Phe Lys  Lys Gly Leu 
    1190                 1195                 1200             


Lys Asp  Met Gly Tyr Gly Asn  Trp Ile Ser Lys Pro  Gln Glu Glu 
    1205                 1210                 1215             


Lys Asn  Phe Tyr Leu Cys Pro  Val 
    1220                 1225     

<210>  76
<211>  6562
<212>  DNA
<213>  Homo sapiens

<400>  76
gaggaaacga aagcgaaatt gaaccggagc catcttgggc ccggcgcgca gacccgcgga     60

gtttcccgtg ccgacgcccc ggggccactt ccagtgcgga gtagcggagg cgtgggggcc    120

tcgaggggct ggcgcggccc agcggtcggg ccagggtcgt gccgccggcg ggtcgggccg    180

ggcaatgcct cgcgggcgca atgaatccgc ggcaggggta ttccctcagc ggatactaca    240

cccatccatt tcaaggctat gagcacagac agctcaggta ccagcagcct gggccaggat    300

cttcccccag tagtttcctg cttaagcaaa tagaatttct caaggggcag ctcccagaag    360

caccggtgat tggaaagcag acaccgtcac tgccaccttc cctcccagga ctccggccaa    420

ggtttccagt actacttgcc tccagtacca gaggcaggca agtggacatc aggggtgtcc    480

ccaggggcgt gcatctcgga agtcaggggc tccagagagg gttccagcat ccttcaccac    540

gtggcaggag tctgccacag agaggtgttg attgcctttc ctcacatttc caggaactga    600

gtatctacca agatcaggaa caaaggatct taaagttcct ggaagagctt ggggaaggga    660

aggccaccac agcacatgat ctgtctggga aacttgggac tccgaagaaa gaaatcaatc    720

gagttttata ctccctggca aagaagggca agctacagaa agaggcagga acaccccctt    780

tgtggaaaat cgcggtctcc actcaggctt ggaaccagca cagcggagtg gtaagaccag    840

acggtcatag ccaaggagcc ccaaactcag acccgagttt ggaaccggaa gacagaaact    900

ccacatctgt ctcagaagat cttcttgagc cttttattgc agtctcagct caggcttgga    960

accagcacag cggagtggta agaccagaca gtcatagcca aggatcccca aactcagacc   1020

caggtttgga acctgaagac agcaactcca catctgcctt ggaagatcct cttgagtttt   1080

tagacatggc cgagatcaag gagaaaatct gcgactatct cttcaatgtg tctgactcct   1140

ctgccctgaa tttggctaaa aatattggcc ttaccaaggc ccgagatata aatgctgtgc   1200

taattgacat ggaaaggcag ggggatgtct atagacaagg gacaacccct cccatatggc   1260

atttgacaga caagaagcga gagaggatgc aaatcaagag aaatacgaac agtgttcctg   1320

aaaccgctcc agctgcaatc cctgagacca aaagaaacgc agagttcctc acctgtaata   1380

tacccacatc aaatgcctca aataacatgg taaccacaga aaaagtggag aatgggcagg   1440

aacctgtcat aaagttagaa aacaggcaag aggccagacc agaaccagca agactgaaac   1500

cacctgttca ttacaatggc ccctcaaaag cagggtatgt tgactttgaa aatggccagt   1560

gggccacaga tgacatccca gatgacttga atagtatccg cgcagcacca ggtgagtttc   1620

gagccatcat ggagatgccc tccttctaca gtcatggctt gccacggtgt tcaccctaca   1680

agaaactgac agagtgccag ctgaagaacc ccatcagcgg gctgttagaa tatgcccagt   1740

tcgctagtca aacctgtgag ttcaacatga tagagcagag tggaccaccc catgaacctc   1800

gatttaaatt ccaggttgtc atcaatggcc gagagtttcc cccagctgaa gctggaagca   1860

agaaagtggc caagcaggat gcagctatga aagccatgac aattctgcta gaggaagcca   1920

aagccaagga cagtggaaaa tcagaagaat catcccacta ttccacagag aaagaatcag   1980

agaagactgc agagtcccag acccccaccc cttcagccac atccttcttt tctgggaaga   2040

gccccgtcac cacactgctt gagtgtatgc acaaattggg gaactcctgc gaattccgtc   2100

tcctgtccaa agaaggccct gcccatgaac ccaagttcca atactgtgtt gcagtgggag   2160

cccaaacttt ccccagtgtg agtgctccca gcaagaaagt ggcaaagcag atggccgcag   2220

aggaagccat gaaggccctg catggggagg cgaccaactc catggcttct gataaccagc   2280

ctgaaggtat gatctcagag tcacttgata acttggaatc catgatgccc aacaaggtca   2340

ggaagattgg cgagctcgtg agatacctga acaccaaccc tgtgggtggc cttttggagt   2400

acgcccgctc ccatggcttt gctgctgaat tcaagttggt cgaccagtcc ggacctcctc   2460

acgagcccaa gttcgtttac caagcaaaag ttgggggtcg ctggttccca gccgtctgcg   2520

cacacagcaa gaagcaaggc aagcaggaag cagcagatgc ggctctccgt gtcttgattg   2580

gggagaacga gaaggcagaa cgcatgggtt tcacagagct ccctctcact ggcagcacct   2640

tccatgacca gatagccatg ctgagccacc ggtgcttcaa cactctgact aacagcttcc   2700

agccctcctt gctcggccgc aagattctgg ccgccatcat tatgaaaaaa gactctgagg   2760

acatgggtgt cgtcgtcagc ttgggaacag ggaatcgctg tgtgaaagga gattctctca   2820

gcctaaaagg agaaactgtc aatgactgcc atgcagaaat aatctcccgg agaggcttca   2880

tcaggtttct ctacagtgag ttaatgaaat acaactccca gactgcgaag gatagtatat   2940

ttgaacctgc taagggagga gaaaagctcc aaataaaaaa gactgtgtca ttccatctgt   3000

atatcagcac tgctccgtgt ggagatggcg ccctctttga caagtcctgc agcgaccgtg   3060

ctatggaaag cacagaatcc cgccactacc ctgtcttcga gaatcccaaa caaggaaagc   3120

tccgcaccaa ggtggagaac ggagaaggca caatccctgt ggaatccagt gacattgtgc   3180

ctacgtggga tggcattcgg ctcggggaga gactccgtac catgtcctgt agtgacaaaa   3240

tcctacgctg gaacgtgctg ggcctgcaag gggcactgtt gacccacttc ctgcagccca   3300

tttatctcaa atctgtcaca ttgggttacc ttttcagcca agggcatctg acccgtgcta   3360

tttgctgtcg tgtgacaaga gatgggagtg catttgagga tggactacga catcccttta   3420

ttgtcaacca ccccaaggtt ggcagagtca gcatatatga ttccaaaagg caatccggga   3480

agactaagga gacaagcgtc aactggtgtc tggctgatgg ctatgacctg gagatcctgg   3540

acggtaccag aggcactgtg gatgggccac ggaatgaatt gtcccgggtc tccaaaaaga   3600

acatttttct tctatttaag aagctctgct ccttccgtta ccgcagggat ctactgagac   3660

tctcctatgg tgaggccaag aaagctgccc gtgactacga gacggccaag aactacttca   3720

aaaaaggcct gaaggatatg ggctatggga actggattag caaaccccag gaggaaaaga   3780

acttttatct ctgcccagta tagtatgctc cagtgacaga tggattaggg tgtgtcatac   3840

tagggtgtga gagaggtagg tcgtagcatt cctcatcaca tggtcagggg attttttttt   3900

ctcctttttt tttcttttta agccataatt ggtgatactg aaaactttgg gttcccattt   3960

atcctgcttt ctttgggatt gctaggcaag gtctggccag gccccccttt tttcccccaa   4020

gtgaagaggc agaaacctaa gaagttatct tttctttcta cccaaagcat acatagtcac   4080

tgagcacctg cggtccattt cctcttaaaa gttttgtttt gatttgtttc catttccttt   4140

ccctttgtgt ttgctacact gacctcttgc ggtcttgatt aggtttcagt caactctgga   4200

tcatgtcagg gactgataat ttcatttgtg gattacgcag acccctctac ttcccctctt   4260

tcccttctga gattctttcc ttgtgatctg aatgtctcct tttccccctc agagggcaaa   4320

gaggtgaaca taaaggattt ggtgaaacat ttgtaagggt aggagttgaa aactgcagtt   4380

cccagtgcca cggaagtgtg attggagcct gcagataatg cccagccatc ctcccatcct   4440

gcactttagc cagctgcagg gcgggcaagg caaggaaagc tgcttccctg gaagtgtatc   4500

actttctccg gcagctggga agtctagaac cagccagact gggttaaggg agctgctcaa   4560

gcaatagcag aggtttcacc cggcaggatg acacagacca cttcccaggg agcacgggca   4620

tgccttggaa tattgccaag cttccagctg cctcttctcc taaagcattc ctaggaatat   4680

tttccccgcc aatgctgggc gtacacccta gccaacggga caaatcctag agggtataaa   4740

atcatctctg ctcagataat catgacttag caagaataag ggcaaaaaat cctgttggct   4800

taacgtcact gttccacccg gtgtaatatc tctcatgaca gtgacaccaa gggaagttga   4860

ctaagtcaca tgtaaattag gagtgtttta aagaatgcca tagatgttga ttcttaactg   4920

ctacagataa cctgtaattg agcagattta aaattcaggc atacttttcc atttatccaa   4980

gtgctttcat ttttccagat ggcttcagaa gtaggctcgt gggcagggcg cagacctgat   5040

ctttataggg ttgacataga aagcagtagt tgtgggtgaa agggcaggtt gtcttcaaac   5100

tctgtgaggt agaatccttt gtctatacct ccatgaacat tgactcgtgt gttcagagcc   5160

tttggcctct ctgtggagtc tggctctctg gctcctgtgc attctttgaa tagtcactcg   5220

taaaaactgt cagtgcttga aactgtttcc tttactcatg ttgaagggac tttgttggct   5280

tttagagtgt tggtcatgac tccaagagca gagcagggaa gagcccaagc atagacttgg   5340

tgccgtggtg atggctgcag tccagttttg tgatgctgct tttacgtgtc cctcgataac   5400

agtcagctag acacactcag gaggactact gaggctctgc gaccttcagg agctgagcct   5460

gcctctctcc tttagatgac agaccttcat ctgggaacgt gctgagccag caccctcaga   5520

tgatttccct ccaaactgct gactaggtca tcctctgtct ggtagagaca ttcacatctt   5580

tgcttttatt ctatgctctc tgtacttttg accaaaaatt gaccaaagta agaaaatgca   5640

agttctaaaa atagactaag gatgcctttg cagaacacca aagcatccca aggaactggt   5700

agggaagtgg cgcctgtctc ctggagtgga agaggcctgc tccctggctc tgggtctgct   5760

gggggcacag taaatcagtc ttggcaccca catccagggc agagaggtct gtggttctca   5820

gcatcagaag gcagcgcagc ccctctcctc ttcaggctac agggttgtca cctgctgagt   5880

cctcaggttg tttggcctct ctggtccatc ttgggcatta ggttctccag cagagctctg   5940

gccagctgcc tcttctttaa ctgggaacac aggctctcac aagatcagaa cccccactca   6000

cccccaagat cttatctagc aagcctgtag tattcagttt ctgttgtagg aagagagcga   6060

ggcatccctg aattccacgc atctgctgga aacgagccgt gtcagatcgc acatccctgc   6120

gcccccatgc ccctctgagt cacacaggac agaggaggca gagcttctgc ccactgttat   6180

cttcactttc tttgtccagt cttttgtttt taataagcag tgaccctccc tactcttctt   6240

tttaatgatt tttgtagttg atttgtctga actgtggcta ctgtgcattc cttgaataat   6300

cacttgtaaa aattgtcagt gcttgaagct gtttccttta ctcacattga agggacttcg   6360

ttggtttttt ggagtcttgg ttgtgactcc aagagcagag tgaggaagac ccccaagcat   6420

agactcgggt actgtgatga tggctgcagt ccagttttat gattctgctt ttatgtgtcc   6480

cttgataaca gtgacttaac aatatacatt cctcataaat aaaaaaaaaa caagaatctg   6540

aattcttaga aaaaaaaaaa aa                                            6562


<210>  77
<211>  1200
<212>  PRT
<213>  Homo sapiens

<400>  77


Met Asn Pro Arg Gln Gly Tyr Ser Leu Ser Gly Tyr Tyr Thr His Pro 
1               5                   10                  15      


Phe Gln Gly Tyr Glu His Arg Gln Leu Arg Tyr Gln Gln Pro Gly Pro 
            20                  25                  30          


Gly Ser Ser Pro Ser Ser Phe Leu Leu Lys Gln Ile Glu Phe Leu Lys 
        35                  40                  45              


Gly Gln Leu Pro Glu Ala Pro Val Ile Gly Lys Gln Thr Pro Ser Leu 
    50                  55                  60                  


Pro Pro Ser Leu Pro Gly Leu Arg Pro Arg Phe Pro Val Leu Leu Ala 
65                  70                  75                  80  


Ser Ser Thr Arg Gly Arg Gln Val Asp Ile Arg Gly Val Pro Arg Gly 
                85                  90                  95      


Val His Leu Gly Ser Gln Gly Leu Gln Arg Gly Phe Gln His Pro Ser 
            100                 105                 110         


Pro Arg Gly Arg Ser Leu Pro Gln Arg Gly Val Asp Cys Leu Ser Ser 
        115                 120                 125             


His Phe Gln Glu Leu Ser Ile Tyr Gln Asp Gln Glu Gln Arg Ile Leu 
    130                 135                 140                 


Lys Phe Leu Glu Glu Leu Gly Glu Gly Lys Ala Thr Thr Ala His Asp 
145                 150                 155                 160 


Leu Ser Gly Lys Leu Gly Thr Pro Lys Lys Glu Ile Asn Arg Val Leu 
                165                 170                 175     


Tyr Ser Leu Ala Lys Lys Gly Lys Leu Gln Lys Glu Ala Gly Thr Pro 
            180                 185                 190         


Pro Leu Trp Lys Ile Ala Val Ser Thr Gln Ala Trp Asn Gln His Ser 
        195                 200                 205             


Gly Val Val Arg Pro Asp Gly His Ser Gln Gly Ala Pro Asn Ser Asp 
    210                 215                 220                 


Pro Ser Leu Glu Pro Glu Asp Arg Asn Ser Thr Ser Val Ser Glu Asp 
225                 230                 235                 240 


Leu Leu Glu Pro Phe Ile Ala Val Ser Ala Gln Ala Trp Asn Gln His 
                245                 250                 255     


Ser Gly Val Val Arg Pro Asp Ser His Ser Gln Gly Ser Pro Asn Ser 
            260                 265                 270         


Asp Pro Gly Leu Glu Pro Glu Asp Ser Asn Ser Thr Ser Ala Leu Glu 
        275                 280                 285             


Asp Pro Leu Glu Phe Leu Asp Met Ala Glu Ile Lys Glu Lys Ile Cys 
    290                 295                 300                 


Asp Tyr Leu Phe Asn Val Ser Asp Ser Ser Ala Leu Asn Leu Ala Lys 
305                 310                 315                 320 


Asn Ile Gly Leu Thr Lys Ala Arg Asp Ile Asn Ala Val Leu Ile Asp 
                325                 330                 335     


Met Glu Arg Gln Gly Asp Val Tyr Arg Gln Gly Thr Thr Pro Pro Ile 
            340                 345                 350         


Trp His Leu Thr Asp Lys Lys Arg Glu Arg Met Gln Ile Lys Arg Asn 
        355                 360                 365             


Thr Asn Ser Val Pro Glu Thr Ala Pro Ala Ala Ile Pro Glu Thr Lys 
    370                 375                 380                 


Arg Asn Ala Glu Phe Leu Thr Cys Asn Ile Pro Thr Ser Asn Ala Ser 
385                 390                 395                 400 


Asn Asn Met Val Thr Thr Glu Lys Val Glu Asn Gly Gln Glu Pro Val 
                405                 410                 415     


Ile Lys Leu Glu Asn Arg Gln Glu Ala Arg Pro Glu Pro Ala Arg Leu 
            420                 425                 430         


Lys Pro Pro Val His Tyr Asn Gly Pro Ser Lys Ala Gly Tyr Val Asp 
        435                 440                 445             


Phe Glu Asn Gly Gln Trp Ala Thr Asp Asp Ile Pro Asp Asp Leu Asn 
    450                 455                 460                 


Ser Ile Arg Ala Ala Pro Gly Glu Phe Arg Ala Ile Met Glu Met Pro 
465                 470                 475                 480 


Ser Phe Tyr Ser His Gly Leu Pro Arg Cys Ser Pro Tyr Lys Lys Leu 
                485                 490                 495     


Thr Glu Cys Gln Leu Lys Asn Pro Ile Ser Gly Leu Leu Glu Tyr Ala 
            500                 505                 510         


Gln Phe Ala Ser Gln Thr Cys Glu Phe Asn Met Ile Glu Gln Ser Gly 
        515                 520                 525             


Pro Pro His Glu Pro Arg Phe Lys Phe Gln Val Val Ile Asn Gly Arg 
    530                 535                 540                 


Glu Phe Pro Pro Ala Glu Ala Gly Ser Lys Lys Val Ala Lys Gln Asp 
545                 550                 555                 560 


Ala Ala Met Lys Ala Met Thr Ile Leu Leu Glu Glu Ala Lys Ala Lys 
                565                 570                 575     


Asp Ser Gly Lys Ser Glu Glu Ser Ser His Tyr Ser Thr Glu Lys Glu 
            580                 585                 590         


Ser Glu Lys Thr Ala Glu Ser Gln Thr Pro Thr Pro Ser Ala Thr Ser 
        595                 600                 605             


Phe Phe Ser Gly Lys Ser Pro Val Thr Thr Leu Leu Glu Cys Met His 
    610                 615                 620                 


Lys Leu Gly Asn Ser Cys Glu Phe Arg Leu Leu Ser Lys Glu Gly Pro 
625                 630                 635                 640 


Ala His Glu Pro Lys Phe Gln Tyr Cys Val Ala Val Gly Ala Gln Thr 
                645                 650                 655     


Phe Pro Ser Val Ser Ala Pro Ser Lys Lys Val Ala Lys Gln Met Ala 
            660                 665                 670         


Ala Glu Glu Ala Met Lys Ala Leu His Gly Glu Ala Thr Asn Ser Met 
        675                 680                 685             


Ala Ser Asp Asn Gln Pro Glu Gly Met Ile Ser Glu Ser Leu Asp Asn 
    690                 695                 700                 


Leu Glu Ser Met Met Pro Asn Lys Val Arg Lys Ile Gly Glu Leu Val 
705                 710                 715                 720 


Arg Tyr Leu Asn Thr Asn Pro Val Gly Gly Leu Leu Glu Tyr Ala Arg 
                725                 730                 735     


Ser His Gly Phe Ala Ala Glu Phe Lys Leu Val Asp Gln Ser Gly Pro 
            740                 745                 750         


Pro His Glu Pro Lys Phe Val Tyr Gln Ala Lys Val Gly Gly Arg Trp 
        755                 760                 765             


Phe Pro Ala Val Cys Ala His Ser Lys Lys Gln Gly Lys Gln Glu Ala 
    770                 775                 780                 


Ala Asp Ala Ala Leu Arg Val Leu Ile Gly Glu Asn Glu Lys Ala Glu 
785                 790                 795                 800 


Arg Met Gly Phe Thr Glu Leu Pro Leu Thr Gly Ser Thr Phe His Asp 
                805                 810                 815     


Gln Ile Ala Met Leu Ser His Arg Cys Phe Asn Thr Leu Thr Asn Ser 
            820                 825                 830         


Phe Gln Pro Ser Leu Leu Gly Arg Lys Ile Leu Ala Ala Ile Ile Met 
        835                 840                 845             


Lys Lys Asp Ser Glu Asp Met Gly Val Val Val Ser Leu Gly Thr Gly 
    850                 855                 860                 


Asn Arg Cys Val Lys Gly Asp Ser Leu Ser Leu Lys Gly Glu Thr Val 
865                 870                 875                 880 


Asn Asp Cys His Ala Glu Ile Ile Ser Arg Arg Gly Phe Ile Arg Phe 
                885                 890                 895     


Leu Tyr Ser Glu Leu Met Lys Tyr Asn Ser Gln Thr Ala Lys Asp Ser 
            900                 905                 910         


Ile Phe Glu Pro Ala Lys Gly Gly Glu Lys Leu Gln Ile Lys Lys Thr 
        915                 920                 925             


Val Ser Phe His Leu Tyr Ile Ser Thr Ala Pro Cys Gly Asp Gly Ala 
    930                 935                 940                 


Leu Phe Asp Lys Ser Cys Ser Asp Arg Ala Met Glu Ser Thr Glu Ser 
945                 950                 955                 960 


Arg His Tyr Pro Val Phe Glu Asn Pro Lys Gln Gly Lys Leu Arg Thr 
                965                 970                 975     


Lys Val Glu Asn Gly Glu Gly Thr Ile Pro Val Glu Ser Ser Asp Ile 
            980                 985                 990         


Val Pro Thr Trp Asp Gly Ile Arg  Leu Gly Glu Arg Leu  Arg Thr Met 
        995                 1000                 1005             


Ser Cys  Ser Asp Lys Ile Leu  Arg Trp Asn Val Leu  Gly Leu Gln 
    1010                 1015                 1020             


Gly Ala  Leu Leu Thr His Phe  Leu Gln Pro Ile Tyr  Leu Lys Ser 
    1025                 1030                 1035             


Val Thr  Leu Gly Tyr Leu Phe  Ser Gln Gly His Leu  Thr Arg Ala 
    1040                 1045                 1050             


Ile Cys  Cys Arg Val Thr Arg  Asp Gly Ser Ala Phe  Glu Asp Gly 
    1055                 1060                 1065             


Leu Arg  His Pro Phe Ile Val  Asn His Pro Lys Val  Gly Arg Val 
    1070                 1075                 1080             


Ser Ile  Tyr Asp Ser Lys Arg  Gln Ser Gly Lys Thr  Lys Glu Thr 
    1085                 1090                 1095             


Ser Val  Asn Trp Cys Leu Ala  Asp Gly Tyr Asp Leu  Glu Ile Leu 
    1100                 1105                 1110             


Asp Gly  Thr Arg Gly Thr Val  Asp Gly Pro Arg Asn  Glu Leu Ser 
    1115                 1120                 1125             


Arg Val  Ser Lys Lys Asn Ile  Phe Leu Leu Phe Lys  Lys Leu Cys 
    1130                 1135                 1140             


Ser Phe  Arg Tyr Arg Arg Asp  Leu Leu Arg Leu Ser  Tyr Gly Glu 
    1145                 1150                 1155             


Ala Lys  Lys Ala Ala Arg Asp  Tyr Glu Thr Ala Lys  Asn Tyr Phe 
    1160                 1165                 1170             


Lys Lys  Gly Leu Lys Asp Met  Gly Tyr Gly Asn Trp  Ile Ser Lys 
    1175                 1180                 1185             


Pro Gln  Glu Glu Lys Asn Phe  Tyr Leu Cys Pro Val  
    1190                 1195                 1200 

<210>  78
<211>  6505
<212>  DNA
<213>  Homo sapiens

<400>  78
gaggaaacga aagcgaaatt gaaccggagc catcttgggc ccggcgcgca gacccgcgga     60

gtttcccgtg ccgacgcccc ggggccactt ccagtgcgga gtagcggagg cgtgggggcc    120

tcgaggggct ggcgcggccc agcggtcggg ccagggtcgt gccgccggcg ggtcgggccg    180

ggcaatgcct cgcgggcgca atgaatccgc ggcaggggta ttccctcagc ggatactaca    240

cccatccatt tcaaggctat gagcacagac agctcaggta ccagcagcct gggccaggat    300

cttcccccag tagtttcctg cttaagcaaa tagaatttct caaggggcag ctcccagaag    360

caccggtgat tggaaagcag acaccgtcac tgccaccttc cctcccagga ctccggccaa    420

ggtttccagt actacttgcc tccagtacca gaggcaggca agtggacatc aggggtgtcc    480

ccaggggcgt gcatctcgga agtcaggggc tccagagagg gttccagcat ccttcaccac    540

gtggcaggag tctgccacag agaggtgttg attgcctttc ctcacatttc caggaactga    600

gtatctacca agatcaggaa caaaggatct taaagttcct ggaagagctt ggggaaggga    660

aggccaccac agcacatgat ctgtctggga aacttgggac tccgaagaaa gaaatcaatc    720

gagttttata ctccctggca aagaagggca agctacagaa agaggcagga acaccccctt    780

tgtggaaaat cgcggtctcc actcaggctt ggaaccagca cagcggagtg gtaagaccag    840

acggtcatag ccaaggagcc ccaaactcag acccgagttt ggaaccggaa gacagaaact    900

ccacatctgt ctcagaagat cttcttgagc cttttattgc agtctcagct caggcttgga    960

accagcacag cggagtggta agaccagaca gtcatagcca aggatcccca aactcagacc   1020

caggtttgga acctgaagac agcaactcca catctgcctt ggaagatcct cttgagtttt   1080

tagacatggc cgagatcaag gagaaaatct gcgactatct cttcaatgtg tctgactcct   1140

ctgccctgaa tttggctaaa aatattggcc ttaccaaggc ccgagatata aatgctgtgc   1200

taattgacat ggaaaggcag ggggatgtct atagacaagg gacaacccct cccatatggc   1260

atttgacaga caagaagcga gagaggatgc aaatcaagag aaatacgaac agtgttcctg   1320

aaaccgctcc agctgcaatc cctgagacca aaagaaacgc agagttcctc acctgtaata   1380

tacccacatc aaatgcctca aataacatgg taaccacaga aaaagtggag aatgggcagg   1440

aacctgtcat aaagttagaa aacaggcaag aggccagacc agaaccagca agactgaaac   1500

cacctgttca ttacaatggc ccctcaaaag cagggtatgt tgactttgaa aatggccagt   1560

gggccacaga tgacatccca gatgacttga atagtatccg cgcagcacca ggtgagtttc   1620

gagccatcat ggagatgccc tccttctaca gtcatggctt gccacggtgt tcaccctaca   1680

agaaactgac agagtgccag ctgaagaacc ccatcagcgg gctgttagaa tatgcccagt   1740

tcgctagtca aacctgtgag ttcaacatga tagagcagag tggaccaccc catgaacctc   1800

gatttaaatt ccaggttgtc atcaatggcc gagagtttcc cccagctgaa gctggaagca   1860

agaaagtggc caagcaggat gcagctatga aagccatgac aattctgcta gaggaagcca   1920

aagccaagga cagtggaaaa tcagaagaat catcccacta ttccacagag aaagaatcag   1980

agaagactgc agagtcccag acccccaccc cttcagccac atccttcttt tctgggaaga   2040

gccccgtcac cacactgctt gagtgtatgc acaaattggg gaactcctgc gaattccgtc   2100

tcctgtccaa agaaggccct gcccatgaac ccaagttcca atactgtgtt gcagtgggag   2160

cccaaacttt ccccagtgtg agtgctccca gcaagaaagt ggcaaagcag atggccgcag   2220

aggaagccat gaaggccctg catggggagg cgaccaactc catggcttct gataaccagg   2280

tcaggaagat tggcgagctc gtgagatacc tgaacaccaa ccctgtgggt ggccttttgg   2340

agtacgcccg ctcccatggc tttgctgctg aattcaagtt ggtcgaccag tccggacctc   2400

ctcacgagcc caagttcgtt taccaagcaa aagttggggg tcgctggttc ccagccgtct   2460

gcgcacacag caagaagcaa ggcaagcagg aagcagcaga tgcggctctc cgtgtcttga   2520

ttggggagaa cgagaaggca gaacgcatgg gtttcacaga gctccctctc actggcagca   2580

ccttccatga ccagatagcc atgctgagcc accggtgctt caacactctg actaacagct   2640

tccagccctc cttgctcggc cgcaagattc tggccgccat cattatgaaa aaagactctg   2700

aggacatggg tgtcgtcgtc agcttgggaa cagggaatcg ctgtgtgaaa ggagattctc   2760

tcagcctaaa aggagaaact gtcaatgact gccatgcaga aataatctcc cggagaggct   2820

tcatcaggtt tctctacagt gagttaatga aatacaactc ccagactgcg aaggatagta   2880

tatttgaacc tgctaaggga ggagaaaagc tccaaataaa aaagactgtg tcattccatc   2940

tgtatatcag cactgctccg tgtggagatg gcgccctctt tgacaagtcc tgcagcgacc   3000

gtgctatgga aagcacagaa tcccgccact accctgtctt cgagaatccc aaacaaggaa   3060

agctccgcac caaggtggag aacggagaag gcacaatccc tgtggaatcc agtgacattg   3120

tgcctacgtg ggatggcatt cggctcgggg agagactccg taccatgtcc tgtagtgaca   3180

aaatcctacg ctggaacgtg ctgggcctgc aaggggcact gttgacccac ttcctgcagc   3240

ccatttatct caaatctgtc acattgggtt accttttcag ccaagggcat ctgacccgtg   3300

ctatttgctg tcgtgtgaca agagatggga gtgcatttga ggatggacta cgacatccct   3360

ttattgtcaa ccaccccaag gttggcagag tcagcatata tgattccaaa aggcaatccg   3420

ggaagactaa ggagacaagc gtcaactggt gtctggctga tggctatgac ctggagatcc   3480

tggacggtac cagaggcact gtggatgggc cacggaatga attgtcccgg gtctccaaaa   3540

agaacatttt tcttctattt aagaagctct gctccttccg ttaccgcagg gatctactga   3600

gactctccta tggtgaggcc aagaaagctg cccgtgacta cgagacggcc aagaactact   3660

tcaaaaaagg cctgaaggat atgggctatg ggaactggat tagcaaaccc caggaggaaa   3720

agaactttta tctctgccca gtatagtatg ctccagtgac agatggatta gggtgtgtca   3780

tactagggtg tgagagaggt aggtcgtagc attcctcatc acatggtcag gggatttttt   3840

tttctccttt ttttttcttt ttaagccata attggtgata ctgaaaactt tgggttccca   3900

tttatcctgc tttctttggg attgctaggc aaggtctggc caggcccccc ttttttcccc   3960

caagtgaaga ggcagaaacc taagaagtta tcttttcttt ctacccaaag catacatagt   4020

cactgagcac ctgcggtcca tttcctctta aaagttttgt tttgatttgt ttccatttcc   4080

tttccctttg tgtttgctac actgacctct tgcggtcttg attaggtttc agtcaactct   4140

ggatcatgtc agggactgat aatttcattt gtggattacg cagacccctc tacttcccct   4200

ctttcccttc tgagattctt tccttgtgat ctgaatgtct ccttttcccc ctcagagggc   4260

aaagaggtga acataaagga tttggtgaaa catttgtaag ggtaggagtt gaaaactgca   4320

gttcccagtg ccacggaagt gtgattggag cctgcagata atgcccagcc atcctcccat   4380

cctgcacttt agccagctgc agggcgggca aggcaaggaa agctgcttcc ctggaagtgt   4440

atcactttct ccggcagctg ggaagtctag aaccagccag actgggttaa gggagctgct   4500

caagcaatag cagaggtttc acccggcagg atgacacaga ccacttccca gggagcacgg   4560

gcatgccttg gaatattgcc aagcttccag ctgcctcttc tcctaaagca ttcctaggaa   4620

tattttcccc gccaatgctg ggcgtacacc ctagccaacg ggacaaatcc tagagggtat   4680

aaaatcatct ctgctcagat aatcatgact tagcaagaat aagggcaaaa aatcctgttg   4740

gcttaacgtc actgttccac ccggtgtaat atctctcatg acagtgacac caagggaagt   4800

tgactaagtc acatgtaaat taggagtgtt ttaaagaatg ccatagatgt tgattcttaa   4860

ctgctacaga taacctgtaa ttgagcagat ttaaaattca ggcatacttt tccatttatc   4920

caagtgcttt catttttcca gatggcttca gaagtaggct cgtgggcagg gcgcagacct   4980

gatctttata gggttgacat agaaagcagt agttgtgggt gaaagggcag gttgtcttca   5040

aactctgtga ggtagaatcc tttgtctata cctccatgaa cattgactcg tgtgttcaga   5100

gcctttggcc tctctgtgga gtctggctct ctggctcctg tgcattcttt gaatagtcac   5160

tcgtaaaaac tgtcagtgct tgaaactgtt tcctttactc atgttgaagg gactttgttg   5220

gcttttagag tgttggtcat gactccaaga gcagagcagg gaagagccca agcatagact   5280

tggtgccgtg gtgatggctg cagtccagtt ttgtgatgct gcttttacgt gtccctcgat   5340

aacagtcagc tagacacact caggaggact actgaggctc tgcgaccttc aggagctgag   5400

cctgcctctc tcctttagat gacagacctt catctgggaa cgtgctgagc cagcaccctc   5460

agatgatttc cctccaaact gctgactagg tcatcctctg tctggtagag acattcacat   5520

ctttgctttt attctatgct ctctgtactt ttgaccaaaa attgaccaaa gtaagaaaat   5580

gcaagttcta aaaatagact aaggatgcct ttgcagaaca ccaaagcatc ccaaggaact   5640

ggtagggaag tggcgcctgt ctcctggagt ggaagaggcc tgctccctgg ctctgggtct   5700

gctgggggca cagtaaatca gtcttggcac ccacatccag ggcagagagg tctgtggttc   5760

tcagcatcag aaggcagcgc agcccctctc ctcttcaggc tacagggttg tcacctgctg   5820

agtcctcagg ttgtttggcc tctctggtcc atcttgggca ttaggttctc cagcagagct   5880

ctggccagct gcctcttctt taactgggaa cacaggctct cacaagatca gaacccccac   5940

tcacccccaa gatcttatct agcaagcctg tagtattcag tttctgttgt aggaagagag   6000

cgaggcatcc ctgaattcca cgcatctgct ggaaacgagc cgtgtcagat cgcacatccc   6060

tgcgccccca tgcccctctg agtcacacag gacagaggag gcagagcttc tgcccactgt   6120

tatcttcact ttctttgtcc agtcttttgt ttttaataag cagtgaccct ccctactctt   6180

ctttttaatg atttttgtag ttgatttgtc tgaactgtgg ctactgtgca ttccttgaat   6240

aatcacttgt aaaaattgtc agtgcttgaa gctgtttcct ttactcacat tgaagggact   6300

tcgttggttt tttggagtct tggttgtgac tccaagagca gagtgaggaa gacccccaag   6360

catagactcg ggtactgtga tgatggctgc agtccagttt tatgattctg cttttatgtg   6420

tcccttgata acagtgactt aacaatatac attcctcata aataaaaaaa aaacaagaat   6480

ctgaattctt agaaaaaaaa aaaaa                                         6505


<210>  79
<211>  1181
<212>  PRT
<213>  Homo sapiens

<400>  79


Met Asn Pro Arg Gln Gly Tyr Ser Leu Ser Gly Tyr Tyr Thr His Pro 
1               5                   10                  15      


Phe Gln Gly Tyr Glu His Arg Gln Leu Arg Tyr Gln Gln Pro Gly Pro 
            20                  25                  30          


Gly Ser Ser Pro Ser Ser Phe Leu Leu Lys Gln Ile Glu Phe Leu Lys 
        35                  40                  45              


Gly Gln Leu Pro Glu Ala Pro Val Ile Gly Lys Gln Thr Pro Ser Leu 
    50                  55                  60                  


Pro Pro Ser Leu Pro Gly Leu Arg Pro Arg Phe Pro Val Leu Leu Ala 
65                  70                  75                  80  


Ser Ser Thr Arg Gly Arg Gln Val Asp Ile Arg Gly Val Pro Arg Gly 
                85                  90                  95      


Val His Leu Gly Ser Gln Gly Leu Gln Arg Gly Phe Gln His Pro Ser 
            100                 105                 110         


Pro Arg Gly Arg Ser Leu Pro Gln Arg Gly Val Asp Cys Leu Ser Ser 
        115                 120                 125             


His Phe Gln Glu Leu Ser Ile Tyr Gln Asp Gln Glu Gln Arg Ile Leu 
    130                 135                 140                 


Lys Phe Leu Glu Glu Leu Gly Glu Gly Lys Ala Thr Thr Ala His Asp 
145                 150                 155                 160 


Leu Ser Gly Lys Leu Gly Thr Pro Lys Lys Glu Ile Asn Arg Val Leu 
                165                 170                 175     


Tyr Ser Leu Ala Lys Lys Gly Lys Leu Gln Lys Glu Ala Gly Thr Pro 
            180                 185                 190         


Pro Leu Trp Lys Ile Ala Val Ser Thr Gln Ala Trp Asn Gln His Ser 
        195                 200                 205             


Gly Val Val Arg Pro Asp Gly His Ser Gln Gly Ala Pro Asn Ser Asp 
    210                 215                 220                 


Pro Ser Leu Glu Pro Glu Asp Arg Asn Ser Thr Ser Val Ser Glu Asp 
225                 230                 235                 240 


Leu Leu Glu Pro Phe Ile Ala Val Ser Ala Gln Ala Trp Asn Gln His 
                245                 250                 255     


Ser Gly Val Val Arg Pro Asp Ser His Ser Gln Gly Ser Pro Asn Ser 
            260                 265                 270         


Asp Pro Gly Leu Glu Pro Glu Asp Ser Asn Ser Thr Ser Ala Leu Glu 
        275                 280                 285             


Asp Pro Leu Glu Phe Leu Asp Met Ala Glu Ile Lys Glu Lys Ile Cys 
    290                 295                 300                 


Asp Tyr Leu Phe Asn Val Ser Asp Ser Ser Ala Leu Asn Leu Ala Lys 
305                 310                 315                 320 


Asn Ile Gly Leu Thr Lys Ala Arg Asp Ile Asn Ala Val Leu Ile Asp 
                325                 330                 335     


Met Glu Arg Gln Gly Asp Val Tyr Arg Gln Gly Thr Thr Pro Pro Ile 
            340                 345                 350         


Trp His Leu Thr Asp Lys Lys Arg Glu Arg Met Gln Ile Lys Arg Asn 
        355                 360                 365             


Thr Asn Ser Val Pro Glu Thr Ala Pro Ala Ala Ile Pro Glu Thr Lys 
    370                 375                 380                 


Arg Asn Ala Glu Phe Leu Thr Cys Asn Ile Pro Thr Ser Asn Ala Ser 
385                 390                 395                 400 


Asn Asn Met Val Thr Thr Glu Lys Val Glu Asn Gly Gln Glu Pro Val 
                405                 410                 415     


Ile Lys Leu Glu Asn Arg Gln Glu Ala Arg Pro Glu Pro Ala Arg Leu 
            420                 425                 430         


Lys Pro Pro Val His Tyr Asn Gly Pro Ser Lys Ala Gly Tyr Val Asp 
        435                 440                 445             


Phe Glu Asn Gly Gln Trp Ala Thr Asp Asp Ile Pro Asp Asp Leu Asn 
    450                 455                 460                 


Ser Ile Arg Ala Ala Pro Gly Glu Phe Arg Ala Ile Met Glu Met Pro 
465                 470                 475                 480 


Ser Phe Tyr Ser His Gly Leu Pro Arg Cys Ser Pro Tyr Lys Lys Leu 
                485                 490                 495     


Thr Glu Cys Gln Leu Lys Asn Pro Ile Ser Gly Leu Leu Glu Tyr Ala 
            500                 505                 510         


Gln Phe Ala Ser Gln Thr Cys Glu Phe Asn Met Ile Glu Gln Ser Gly 
        515                 520                 525             


Pro Pro His Glu Pro Arg Phe Lys Phe Gln Val Val Ile Asn Gly Arg 
    530                 535                 540                 


Glu Phe Pro Pro Ala Glu Ala Gly Ser Lys Lys Val Ala Lys Gln Asp 
545                 550                 555                 560 


Ala Ala Met Lys Ala Met Thr Ile Leu Leu Glu Glu Ala Lys Ala Lys 
                565                 570                 575     


Asp Ser Gly Lys Ser Glu Glu Ser Ser His Tyr Ser Thr Glu Lys Glu 
            580                 585                 590         


Ser Glu Lys Thr Ala Glu Ser Gln Thr Pro Thr Pro Ser Ala Thr Ser 
        595                 600                 605             


Phe Phe Ser Gly Lys Ser Pro Val Thr Thr Leu Leu Glu Cys Met His 
    610                 615                 620                 


Lys Leu Gly Asn Ser Cys Glu Phe Arg Leu Leu Ser Lys Glu Gly Pro 
625                 630                 635                 640 


Ala His Glu Pro Lys Phe Gln Tyr Cys Val Ala Val Gly Ala Gln Thr 
                645                 650                 655     


Phe Pro Ser Val Ser Ala Pro Ser Lys Lys Val Ala Lys Gln Met Ala 
            660                 665                 670         


Ala Glu Glu Ala Met Lys Ala Leu His Gly Glu Ala Thr Asn Ser Met 
        675                 680                 685             


Ala Ser Asp Asn Gln Val Arg Lys Ile Gly Glu Leu Val Arg Tyr Leu 
    690                 695                 700                 


Asn Thr Asn Pro Val Gly Gly Leu Leu Glu Tyr Ala Arg Ser His Gly 
705                 710                 715                 720 


Phe Ala Ala Glu Phe Lys Leu Val Asp Gln Ser Gly Pro Pro His Glu 
                725                 730                 735     


Pro Lys Phe Val Tyr Gln Ala Lys Val Gly Gly Arg Trp Phe Pro Ala 
            740                 745                 750         


Val Cys Ala His Ser Lys Lys Gln Gly Lys Gln Glu Ala Ala Asp Ala 
        755                 760                 765             


Ala Leu Arg Val Leu Ile Gly Glu Asn Glu Lys Ala Glu Arg Met Gly 
    770                 775                 780                 


Phe Thr Glu Leu Pro Leu Thr Gly Ser Thr Phe His Asp Gln Ile Ala 
785                 790                 795                 800 


Met Leu Ser His Arg Cys Phe Asn Thr Leu Thr Asn Ser Phe Gln Pro 
                805                 810                 815     


Ser Leu Leu Gly Arg Lys Ile Leu Ala Ala Ile Ile Met Lys Lys Asp 
            820                 825                 830         


Ser Glu Asp Met Gly Val Val Val Ser Leu Gly Thr Gly Asn Arg Cys 
        835                 840                 845             


Val Lys Gly Asp Ser Leu Ser Leu Lys Gly Glu Thr Val Asn Asp Cys 
    850                 855                 860                 


His Ala Glu Ile Ile Ser Arg Arg Gly Phe Ile Arg Phe Leu Tyr Ser 
865                 870                 875                 880 


Glu Leu Met Lys Tyr Asn Ser Gln Thr Ala Lys Asp Ser Ile Phe Glu 
                885                 890                 895     


Pro Ala Lys Gly Gly Glu Lys Leu Gln Ile Lys Lys Thr Val Ser Phe 
            900                 905                 910         


His Leu Tyr Ile Ser Thr Ala Pro Cys Gly Asp Gly Ala Leu Phe Asp 
        915                 920                 925             


Lys Ser Cys Ser Asp Arg Ala Met Glu Ser Thr Glu Ser Arg His Tyr 
    930                 935                 940                 


Pro Val Phe Glu Asn Pro Lys Gln Gly Lys Leu Arg Thr Lys Val Glu 
945                 950                 955                 960 


Asn Gly Glu Gly Thr Ile Pro Val Glu Ser Ser Asp Ile Val Pro Thr 
                965                 970                 975     


Trp Asp Gly Ile Arg Leu Gly Glu Arg Leu Arg Thr Met Ser Cys Ser 
            980                 985                 990         


Asp Lys Ile Leu Arg Trp Asn Val  Leu Gly Leu Gln Gly  Ala Leu Leu 
        995                 1000                 1005             


Thr His  Phe Leu Gln Pro Ile  Tyr Leu Lys Ser Val  Thr Leu Gly 
    1010                 1015                 1020             


Tyr Leu  Phe Ser Gln Gly His  Leu Thr Arg Ala Ile  Cys Cys Arg 
    1025                 1030                 1035             


Val Thr  Arg Asp Gly Ser Ala  Phe Glu Asp Gly Leu  Arg His Pro 
    1040                 1045                 1050             


Phe Ile  Val Asn His Pro Lys  Val Gly Arg Val Ser  Ile Tyr Asp 
    1055                 1060                 1065             


Ser Lys  Arg Gln Ser Gly Lys  Thr Lys Glu Thr Ser  Val Asn Trp 
    1070                 1075                 1080             


Cys Leu  Ala Asp Gly Tyr Asp  Leu Glu Ile Leu Asp  Gly Thr Arg 
    1085                 1090                 1095             


Gly Thr  Val Asp Gly Pro Arg  Asn Glu Leu Ser Arg  Val Ser Lys 
    1100                 1105                 1110             


Lys Asn  Ile Phe Leu Leu Phe  Lys Lys Leu Cys Ser  Phe Arg Tyr 
    1115                 1120                 1125             


Arg Arg  Asp Leu Leu Arg Leu  Ser Tyr Gly Glu Ala  Lys Lys Ala 
    1130                 1135                 1140             


Ala Arg  Asp Tyr Glu Thr Ala  Lys Asn Tyr Phe Lys  Lys Gly Leu 
    1145                 1150                 1155             


Lys Asp  Met Gly Tyr Gly Asn  Trp Ile Ser Lys Pro  Gln Glu Glu 
    1160                 1165                 1170             


Lys Asn  Phe Tyr Leu Cys Pro  Val 
    1175                 1180     

<210>  80
<211>  3060
<212>  DNA
<213>  Homo sapiens

<400>  80
gagccagcga ggagtgaagc tgagcctggc ctcacacgct cctagaggac cacctcctga     60

gagagttctt tcaccccctc ttctttctcc aagctcccct cctgctctcc ctccctgccc    120

aatacaatgc attcttgagt ggcagcgtct ggactccagg cagccccaga gaaccgaagc    180

aagccaaaga gaggactgga gccaagatac tggtggggga gattggatgc ctggctttct    240

ttgaggacat ctttggagcg agggtggctt tggggtgggg gcttgtgctg cagggaatac    300

agccaggccc caagatggac acttctgggc acttccatga ctcgggggtg ggggacttgg    360

atgaagaccc caagtgcccc tgtccatcct ctggggatga gcagcagcag cagcagcagc    420

agcaacagca gcagcagcca ccaccgccag cgccaccagc agccccccag cagcccctgg    480

gaccctcgct gcagcctcag cctccgcagc ttcagcagca gcagcagcag cagcagcagc    540

agcagcagca gcagccaccg catcccctgt ctcagctcgc ccaactccag agccagcccg    600

tccaccctgg cctgctgcac tcctctccca ccgctttcag ggccccccct tcgtccaact    660

ccaccgccat cctccaccct tcctccaggc aaggcagcca gctcaatctc aatgaccact    720

tgcttggcca ctctccaagt tccacagcta caagtgggcc tggcggaggc agccggcacc    780

gacaggccag ccccctggtg caccggcggg acagcaaccc cttcacggag atcgccatga    840

gctcctgcaa gtatagcggt ggggtcatga agcccctcag ccgcctcagc gcctcccgga    900

ggaacctcat cgaggccgag actgagggcc aacccctcca gcttttcagc cctagcaacc    960

ccccggagat cgtcatctcc tcccgggagg acaaccatgc ccaccagacc ctgctccatc   1020

accctaatgc cacccacaac caccagcatg ccggcaccac cgccagcagc accaccttcc   1080

ccaaagccaa caagcggaaa aaccaaaaca ttggctataa gctgggacac aggagggccc   1140

tgtttgaaaa gagaaagcga ctgagtgact atgctctgat ttttgggatg tttggaattg   1200

ttgttatggt gatagagacc gagctctctt ggggtttgta ctcaaaggac tccatgtttt   1260

cgttggccct gaaatgcctt atcagtctgt ccaccatcat ccttttgggc ttgatcatcg   1320

cctaccacac acgtgaagtc cagctcttcg tgatcgacaa tggcgcggat gactggcgga   1380

tagccatgac ctacgagcgc atcctgtaca tcagcctgga gatgctggtg tgcgccatcc   1440

accccattcc tggcgagtac aagttcttct ggacggcacg cctggccttc tcctacacac   1500

cctcccgggc ggaggccgat gtggacatca tcctgtctat ccccatgttc ctgcgcctgt   1560

acctgatcgc ccgagtcatg ctgctgcaca gcaagctctt caccgatgcc tcgtcccgca   1620

gcatcggggc cctcaacaag atcaacttca acacccgctt tgtcatgaag acgctcatga   1680

ccatctgccc tggcactgtg ctgctcgtgt tcagcatctc tctgtggatc attgctgcct   1740

ggaccgtccg tgtctgtgaa aggtaccatg accagcagga cgtaactagt aactttctgg   1800

gtgccatgtg gctcatctcc atcacattcc tttccattgg ttatggggac atggtgcccc   1860

acacatactg tgggaaaggt gtctgtctcc tcactggcat catgggtgca ggctgcactg   1920

cccttgtggt ggccgtggtg gcccgaaagc tggaactcac caaagcggag aagcacgttc   1980

ataacttcat gatggacact cagctcacca agcggatcaa gaatgctgca gccaatgtcc   2040

ttcgggaaac atggttaatc tataaacaca caaagctgct aaagaagatt gaccatgcca   2100

aagtgaggaa acaccagagg aagttcctcc aagctatcca ccagttgagg agcgtcaaga   2160

tggaacagag gaagctgagt gaccaagcca acactctggt ggacctttcc aagatgcaga   2220

atgtcatgta tgacttaatc acagaactca atgaccggag cgaagacctg gagaagcaga   2280

ttggcagcct ggagtcgaag ctggagcatc tcaccgccag cttcaactcc ctgccgctgc   2340

tcatcgccga caccctgcgc cagcagcagc agcagctcct gtctgccatc atcgaggccc   2400

ggggtgtcag cgtggcagtg ggcaccaccc acaccccaat ctccgatagc cccattgggg   2460

tcagctccac ctccttcccg accccgtaca caagttcaag cagttgctaa ataaatctcc   2520

ccactccaga agcattaccc ataggtctta agatgcaaat caactctctc ctggtcgctt   2580

tgccatcaag aaacattcag accagggaac ggaaagaaga gagaccgagc taattaacta   2640

actcatgttc attcagcgtg cttggtccga catgccttga aaccagaaat ctaatctctg   2700

tttaggtgcc tctacttggg agcgggaaga ggagatgaca ggaagcgacg cctctggcag   2760

ggcccttgct gcagagttgg tggagaacag aaatccacgc tcaatctcag gtcttcacgc   2820

ggggggtggg ggtcagatgc actgaagtag ccaacagcga agccagtcca gaagaggggt   2880

ccgctgggag ggagggttgt gtcaggcttg ggggatgggc tcttcgccat gggggtcttt   2940

gaacacacct ctctcctttc cttttgtcta cggaagcctc tgggtgacaa aagtaaaaga   3000

gagctgccca caacttgcca aaacagatat actcgaatca gactgaaaaa aaaaaaaaaa   3060


<210>  81
<211>  731
<212>  PRT
<213>  Homo sapiens

<400>  81


Met Asp Thr Ser Gly His Phe His Asp Ser Gly Val Gly Asp Leu Asp 
1               5                   10                  15      


Glu Asp Pro Lys Cys Pro Cys Pro Ser Ser Gly Asp Glu Gln Gln Gln 
            20                  25                  30          


Gln Gln Gln Gln Gln Gln Gln Gln Gln Pro Pro Pro Pro Ala Pro Pro 
        35                  40                  45              


Ala Ala Pro Gln Gln Pro Leu Gly Pro Ser Leu Gln Pro Gln Pro Pro 
    50                  55                  60                  


Gln Leu Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
65                  70                  75                  80  


Pro Pro His Pro Leu Ser Gln Leu Ala Gln Leu Gln Ser Gln Pro Val 
                85                  90                  95      


His Pro Gly Leu Leu His Ser Ser Pro Thr Ala Phe Arg Ala Pro Pro 
            100                 105                 110         


Ser Ser Asn Ser Thr Ala Ile Leu His Pro Ser Ser Arg Gln Gly Ser 
        115                 120                 125             


Gln Leu Asn Leu Asn Asp His Leu Leu Gly His Ser Pro Ser Ser Thr 
    130                 135                 140                 


Ala Thr Ser Gly Pro Gly Gly Gly Ser Arg His Arg Gln Ala Ser Pro 
145                 150                 155                 160 


Leu Val His Arg Arg Asp Ser Asn Pro Phe Thr Glu Ile Ala Met Ser 
                165                 170                 175     


Ser Cys Lys Tyr Ser Gly Gly Val Met Lys Pro Leu Ser Arg Leu Ser 
            180                 185                 190         


Ala Ser Arg Arg Asn Leu Ile Glu Ala Glu Thr Glu Gly Gln Pro Leu 
        195                 200                 205             


Gln Leu Phe Ser Pro Ser Asn Pro Pro Glu Ile Val Ile Ser Ser Arg 
    210                 215                 220                 


Glu Asp Asn His Ala His Gln Thr Leu Leu His His Pro Asn Ala Thr 
225                 230                 235                 240 


His Asn His Gln His Ala Gly Thr Thr Ala Ser Ser Thr Thr Phe Pro 
                245                 250                 255     


Lys Ala Asn Lys Arg Lys Asn Gln Asn Ile Gly Tyr Lys Leu Gly His 
            260                 265                 270         


Arg Arg Ala Leu Phe Glu Lys Arg Lys Arg Leu Ser Asp Tyr Ala Leu 
        275                 280                 285             


Ile Phe Gly Met Phe Gly Ile Val Val Met Val Ile Glu Thr Glu Leu 
    290                 295                 300                 


Ser Trp Gly Leu Tyr Ser Lys Asp Ser Met Phe Ser Leu Ala Leu Lys 
305                 310                 315                 320 


Cys Leu Ile Ser Leu Ser Thr Ile Ile Leu Leu Gly Leu Ile Ile Ala 
                325                 330                 335     


Tyr His Thr Arg Glu Val Gln Leu Phe Val Ile Asp Asn Gly Ala Asp 
            340                 345                 350         


Asp Trp Arg Ile Ala Met Thr Tyr Glu Arg Ile Leu Tyr Ile Ser Leu 
        355                 360                 365             


Glu Met Leu Val Cys Ala Ile His Pro Ile Pro Gly Glu Tyr Lys Phe 
    370                 375                 380                 


Phe Trp Thr Ala Arg Leu Ala Phe Ser Tyr Thr Pro Ser Arg Ala Glu 
385                 390                 395                 400 


Ala Asp Val Asp Ile Ile Leu Ser Ile Pro Met Phe Leu Arg Leu Tyr 
                405                 410                 415     


Leu Ile Ala Arg Val Met Leu Leu His Ser Lys Leu Phe Thr Asp Ala 
            420                 425                 430         


Ser Ser Arg Ser Ile Gly Ala Leu Asn Lys Ile Asn Phe Asn Thr Arg 
        435                 440                 445             


Phe Val Met Lys Thr Leu Met Thr Ile Cys Pro Gly Thr Val Leu Leu 
    450                 455                 460                 


Val Phe Ser Ile Ser Leu Trp Ile Ile Ala Ala Trp Thr Val Arg Val 
465                 470                 475                 480 


Cys Glu Arg Tyr His Asp Gln Gln Asp Val Thr Ser Asn Phe Leu Gly 
                485                 490                 495     


Ala Met Trp Leu Ile Ser Ile Thr Phe Leu Ser Ile Gly Tyr Gly Asp 
            500                 505                 510         


Met Val Pro His Thr Tyr Cys Gly Lys Gly Val Cys Leu Leu Thr Gly 
        515                 520                 525             


Ile Met Gly Ala Gly Cys Thr Ala Leu Val Val Ala Val Val Ala Arg 
    530                 535                 540                 


Lys Leu Glu Leu Thr Lys Ala Glu Lys His Val His Asn Phe Met Met 
545                 550                 555                 560 


Asp Thr Gln Leu Thr Lys Arg Ile Lys Asn Ala Ala Ala Asn Val Leu 
                565                 570                 575     


Arg Glu Thr Trp Leu Ile Tyr Lys His Thr Lys Leu Leu Lys Lys Ile 
            580                 585                 590         


Asp His Ala Lys Val Arg Lys His Gln Arg Lys Phe Leu Gln Ala Ile 
        595                 600                 605             


His Gln Leu Arg Ser Val Lys Met Glu Gln Arg Lys Leu Ser Asp Gln 
    610                 615                 620                 


Ala Asn Thr Leu Val Asp Leu Ser Lys Met Gln Asn Val Met Tyr Asp 
625                 630                 635                 640 


Leu Ile Thr Glu Leu Asn Asp Arg Ser Glu Asp Leu Glu Lys Gln Ile 
                645                 650                 655     


Gly Ser Leu Glu Ser Lys Leu Glu His Leu Thr Ala Ser Phe Asn Ser 
            660                 665                 670         


Leu Pro Leu Leu Ile Ala Asp Thr Leu Arg Gln Gln Gln Gln Gln Leu 
        675                 680                 685             


Leu Ser Ala Ile Ile Glu Ala Arg Gly Val Ser Val Ala Val Gly Thr 
    690                 695                 700                 


Thr His Thr Pro Ile Ser Asp Ser Pro Ile Gly Val Ser Ser Thr Ser 
705                 710                 715                 720 


Phe Pro Thr Pro Tyr Thr Ser Ser Ser Ser Cys 
                725                 730     

<210>  82
<211>  1981
<212>  DNA
<213>  Homo sapiens

<400>  82
ctgctcagtg tcaaattaac aggaaagtca gcttaaagga cactccttgc agggactgag     60

ctggcaccta ctccttagag cttgctgata ccaggcctgc cacgcgacat ctgcaaggac    120

agttgtttgg tgttttgctt caggttatag atggagagac ctataaagga ctccatgttt    180

tcgttggccc tgaaatgcct tatcagtctg tccaccatca tccttttggg cttgatcatc    240

gcctaccaca cacgtgaagt ccagctcttc gtgatcgaca atggcgcgga tgactggcgg    300

atagccatga cctacgagcg catcctgtac atcagcctgg agatgctggt gtgcgccatc    360

caccccattc ctggcgagta caagttcttc tggacggcac gcctggcctt ctcctacaca    420

ccctcccggg cggaggccga tgtggacatc atcctgtcta tccccatgtt cctgcgcctg    480

tacctgatcg cccgagtcat gctgctgcac agcaagctct tcaccgatgc ctcgtcccgc    540

agcatcgggg ccctcaacaa gatcaacttc aacacccgct ttgtcatgaa gacgctcatg    600

accatctgcc ctggcactgt gctgctcgtg ttcagcatct ctctgtggat cattgctgcc    660

tggaccgtcc gtgtctgtga aaggtaccat gaccagcagg acgtaactag taactttctg    720

ggtgccatgt ggctcatctc catcacattc ctttccattg gttatgggga catggtgccc    780

cacacatact gtgggaaagg tgtctgtctc ctcactggca tcatgggtgc aggctgcact    840

gcccttgtgg tggccgtggt ggcccgaaag ctggaactca ccaaagcgga gaagcacgtt    900

cataacttca tgatggacac tcagctcacc aagcggatca agaatgctgc agccaatgtc    960

cttcgggaaa catggttaat ctataaacac acaaagctgc taaagaagat tgaccatgcc   1020

aaagtgagga aacaccagag gaagttcctc caagctatcc accagttgag gagcgtcaag   1080

atggaacaga ggaagctgag tgaccaagcc aacactctgg tggacctttc caagatgcag   1140

aatgtcatgt atgacttaat cacagaactc aatgaccgga gcgaagacct ggagaagcag   1200

attggcagcc tggagtcgaa gctggagcat ctcaccgcca gcttcaactc cctgccgctg   1260

ctcatcgccg acaccctgcg ccagcagcag cagcagctcc tgtctgccat catcgaggcc   1320

cggggtgtca gcgtggcagt gggcaccacc cacaccccaa tctccgatag ccccattggg   1380

gtcagctcca cctccttccc gaccccgtac acaagttcaa gcagttgcta aataaatctc   1440

cccactccag aagcattacc cataggtctt aagatgcaaa tcaactctct cctggtcgct   1500

ttgccatcaa gaaacattca gaccagggaa cggaaagaag agagaccgag ctaattaact   1560

aactcatgtt cattcagcgt gcttggtccg acatgccttg aaaccagaaa tctaatctct   1620

gtttaggtgc ctctacttgg gagcgggaag aggagatgac aggaagcgac gcctctggca   1680

gggcccttgc tgcagagttg gtggagaaca gaaatccacg ctcaatctca ggtcttcacg   1740

cggggggtgg gggtcagatg cactgaagta gccaacagcg aagccagtcc agaagagggg   1800

tccgctggga gggagggttg tgtcaggctt gggggatggg ctcttcgcca tgggggtctt   1860

tgaacacacc tctctccttt ccttttgtct acggaagcct ctgggtgaca aaagtaaaag   1920

agagctgccc acaacttgcc aaaacagata tactcgaatc agactgaaaa aaaaaaaaaa   1980

a                                                                   1981


<210>  83
<211>  426
<212>  PRT
<213>  Homo sapiens

<400>  83


Met Glu Arg Pro Ile Lys Asp Ser Met Phe Ser Leu Ala Leu Lys Cys 
1               5                   10                  15      


Leu Ile Ser Leu Ser Thr Ile Ile Leu Leu Gly Leu Ile Ile Ala Tyr 
            20                  25                  30          


His Thr Arg Glu Val Gln Leu Phe Val Ile Asp Asn Gly Ala Asp Asp 
        35                  40                  45              


Trp Arg Ile Ala Met Thr Tyr Glu Arg Ile Leu Tyr Ile Ser Leu Glu 
    50                  55                  60                  


Met Leu Val Cys Ala Ile His Pro Ile Pro Gly Glu Tyr Lys Phe Phe 
65                  70                  75                  80  


Trp Thr Ala Arg Leu Ala Phe Ser Tyr Thr Pro Ser Arg Ala Glu Ala 
                85                  90                  95      


Asp Val Asp Ile Ile Leu Ser Ile Pro Met Phe Leu Arg Leu Tyr Leu 
            100                 105                 110         


Ile Ala Arg Val Met Leu Leu His Ser Lys Leu Phe Thr Asp Ala Ser 
        115                 120                 125             


Ser Arg Ser Ile Gly Ala Leu Asn Lys Ile Asn Phe Asn Thr Arg Phe 
    130                 135                 140                 


Val Met Lys Thr Leu Met Thr Ile Cys Pro Gly Thr Val Leu Leu Val 
145                 150                 155                 160 


Phe Ser Ile Ser Leu Trp Ile Ile Ala Ala Trp Thr Val Arg Val Cys 
                165                 170                 175     


Glu Arg Tyr His Asp Gln Gln Asp Val Thr Ser Asn Phe Leu Gly Ala 
            180                 185                 190         


Met Trp Leu Ile Ser Ile Thr Phe Leu Ser Ile Gly Tyr Gly Asp Met 
        195                 200                 205             


Val Pro His Thr Tyr Cys Gly Lys Gly Val Cys Leu Leu Thr Gly Ile 
    210                 215                 220                 


Met Gly Ala Gly Cys Thr Ala Leu Val Val Ala Val Val Ala Arg Lys 
225                 230                 235                 240 


Leu Glu Leu Thr Lys Ala Glu Lys His Val His Asn Phe Met Met Asp 
                245                 250                 255     


Thr Gln Leu Thr Lys Arg Ile Lys Asn Ala Ala Ala Asn Val Leu Arg 
            260                 265                 270         


Glu Thr Trp Leu Ile Tyr Lys His Thr Lys Leu Leu Lys Lys Ile Asp 
        275                 280                 285             


His Ala Lys Val Arg Lys His Gln Arg Lys Phe Leu Gln Ala Ile His 
    290                 295                 300                 


Gln Leu Arg Ser Val Lys Met Glu Gln Arg Lys Leu Ser Asp Gln Ala 
305                 310                 315                 320 


Asn Thr Leu Val Asp Leu Ser Lys Met Gln Asn Val Met Tyr Asp Leu 
                325                 330                 335     


Ile Thr Glu Leu Asn Asp Arg Ser Glu Asp Leu Glu Lys Gln Ile Gly 
            340                 345                 350         


Ser Leu Glu Ser Lys Leu Glu His Leu Thr Ala Ser Phe Asn Ser Leu 
        355                 360                 365             


Pro Leu Leu Ile Ala Asp Thr Leu Arg Gln Gln Gln Gln Gln Leu Leu 
    370                 375                 380                 


Ser Ala Ile Ile Glu Ala Arg Gly Val Ser Val Ala Val Gly Thr Thr 
385                 390                 395                 400 


His Thr Pro Ile Ser Asp Ser Pro Ile Gly Val Ser Ser Thr Ser Phe 
                405                 410                 415     


Pro Thr Pro Tyr Thr Ser Ser Ser Ser Cys 
            420                 425     

<210>  84
<211>  3733
<212>  DNA
<213>  Homo sapiens

<400>  84
agcggcgggc aggccgggca tggcgtccat ggcggcggcg atcgcggctt cgcgctcggc     60

ggtcatgagc gggaaccggc ctctggacga ccgggagcga aagcgcttca cttacttctc    120

gtcgctgagc cccatggcca ggaagatcat gcaggacaag gagaagatcc gcgagaagta    180

cgggcccgag tgggcgcggc tgccgcccgc gcagcaggac gagatcatcg accggtgcct    240

ggtggggccg cgcgccccgg cgccccgaga ccccggggac tcggaggagc tcacgcgctt    300

ccccggcttg cgcgggccca cgggccagaa ggtggtgcgc ttcggggacg aggatctaac    360

ttggcaagat gagcactctg cccctttctc ctgggaaaca aagagtcaga tggagttcag    420

tatctccgcc ctatccatcc aggagccgag caacggcacc gccgccagcg agcccagacc    480

actgtccaaa gcttcccagg gctcccaggc cctcaagtcc tcccaaggca gcaggtcctc    540

cagcctggac gccctgggcc ccaccaggaa ggaggaggaa gcgtcattct ggaagatcaa    600

tgctgagcgg tcccgagggg aggggcctga ggccgagttc cagtcgctga cccctagcca    660

gatcaagtcc atggagaagg gggaaaaggt cttgcctccc tgctaccggc aggaacctgc    720

cccgaaggac agggaggcca aggtggaaag gcccagcacc ctccgtcagg agcagcgtcc    780

tcttcccaac gtgagcaccg aacgtgagag accccagcct gtccaggcct tcagcagtgc    840

actgcacgag gctgccccct cccagctcga ggggaagctg ccatctcctg atgtcaggca    900

ggacgatggg gaagacaccc tgttctcgga acccaagttt gcacaggtca gctcaagtaa    960

tgtcgtcttg aagacgggat ttgattttct ggacaattgg taaaatgtat tagaaaaata   1020

caatgaagaa ccctaaaatg ttttccaaag tggtgtggtg gaggaggata aaaagggcca   1080

ccttttccta tgtattttac tggtttcttg acactctttt cttaatcatc tggaaactgg   1140

tcaatattgc cagatttttt tcttttttgg tagaaccaga tatatatgct attttcagtg   1200

atttgataac agaagttttc catttggaat ttttaaggtc tgttaataat tcaggagatc   1260

ttgtaaataa aacttctgtt cccagctcca cccaactttc cccctcctca aaggatgtgt   1320

ttcaaccatg tcacaaaaat catataagtg atttccatct ccttctccat tattccccct   1380

cccccctccg ctttttaccg tatgggttcc ttttggtggg tgattgaggg tgatgttatc   1440

agccatgaca tcagcatgct ggctgtgacc ccggaaagac tggcccccag cgacgttctc   1500

agccagcgct cgcagctgtc cggggcttct ctggcagaag ccatgtctct cacatcatgt   1560

gccagcctcc accctcacgc catttccagg gaacagactg cgggtatgta gcagtgtagt   1620

ctttaacctg ctctgataca tattcagagt atggattgtt gtttaaaaag agttgcatgt   1680

ttaaagagtt ttgtactagc ttttcattat tttgtatcta gattatcaac aatggggcta   1740

ccactttcct tggttttata tccatttcct cttggaagtt cttgttgctt atgtgacctg   1800

ttggttgttc cccggactgg gcacctacag gagtcagggc agacggcaga tgtggctgga   1860

ggtcagggct cttctgctta gttgtgttag agtcttccag catgggactg atgggagcag   1920

tgggcattct ttatcccaag ggctagccag gttgcgtcat gacggacctt ccccagccct   1980

gaccaccacc agaagtggaa gagtggagtt tgcggtcaac tcagcagtgc ccatggagac   2040

ctgcgtggtg tcagagcagc agtatctctt ggagctggtg cagacaccaa ggctgcccag   2100

tggtacaacg tggtccacct cccctaggga agctgctgca ctcagaggct gtcctgccca   2160

gtggcccctg agccgtgtga gcctgcagga ggcgtctgag cagagcctca agcccggtat   2220

ggcgccatct ccatgttgcc atcactgcgt tctcacctga agccttaatc tttgcgacac   2280

ctgccagtga gcgctcggtt tcaataccaa agtgtgtctt cttctttttt ttttttttaa   2340

atgcctgttt cataggacct tctgaaatga tttccagaat attttatctg gctccaaaat   2400

aaagcacata gcaactcacc tcaacccctc atcatctcca ggaaagtttc tgccaaagct   2460

gtggcatagc caacttttga tttggttctt gccaattgtt ttatgtccct aaacctcatt   2520

tggatccttg gggtatagtt ttatctttct gcttcagtga tttactgtaa cttttcaaat   2580

attggttctt tctgtaccat ttaagtatag ttgatatatg tgaggcaaaa aaaggtttca   2640

gcatggtggt gagggaaaaa ggagcttaga aatcccagtt ggcacagcct gggcaagcgc   2700

cagctcccct cagggctaac ggcactgttc acacagggat cctcagaatc agcggccacc   2760

tgcctccacc ttctgcctgg agggcatggg gctgttgtag aacctatggt agcaaatgta   2820

tatgtatgag tttgtattct gtagtgttgg tgtagcacag aagaaagacc tgtgtcctag   2880

agagtaggcc aaggtgatct gcctcttcta ttgggagaaa ttctaatttc tttcccactt   2940

tctcaacaag cccaatattc cctccaagtt cttcttggtg ctgagggctg taggaattat   3000

tgaaagcttc tgcctcactt agtatcgtct ggggcccagc acccagcaat aactctaata   3060

atgtttctta atggtatagc ctcctgagat taaatgtaaa atcaaaaatt aggaaatctt   3120

ggagggagtc ctcaagttgt attgctttgc tgtgcttttg gaagaaggga cgacctggag   3180

gacacaggct cctgtgtggg tcttcatcct gcctgaccgg cagatcttcc tctacacctt   3240

gggcaaagtc tatgcgaaga tggtttctta gctctccatt tgccatgatt ttcctcccat   3300

tcatcatgag ggagtttctc aaaccaggag tttatattta ttttttagaa aatacacact   3360

tttcaggaga aacctgagca tgattttgga ttctccacct ccccccagtc tctgcacctg   3420

ggattcagct caaggattca gtgtcttcat ttttacaaaa gttcccccaa gaaatcagca   3480

accagcctct gtttcatctg ggagcccctc ccttggcccc ctgggtttgg gggtgctgcc   3540

ctactgggaa cagcgggggt ctgtcacccg tctgagccgc acccccctgt gtggatttca   3600

ggaagagcct ccctttcttt gcgtctccct ttctttaatt aacattttca aaagtaataa   3660

attcttactg acgacttgta acttagtcat attttatact tgtagccttt aataaagcca   3720

tttaaaaaat gct                                                      3733


<210>  85
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  85


Met Ala Ser Met Ala Ala Ala Ile Ala Ala Ser Arg Ser Ala Val Met 
1               5                   10                  15      


Ser Gly Asn Arg Pro Leu Asp Asp Arg Glu Arg Lys Arg Phe Thr Tyr 
            20                  25                  30          


Phe Ser Ser Leu Ser Pro Met Ala Arg Lys Ile Met Gln Asp Lys Glu 
        35                  40                  45              


Lys Ile Arg Glu Lys Tyr Gly Pro Glu Trp Ala Arg Leu Pro Pro Ala 
    50                  55                  60                  


Gln Gln Asp Glu Ile Ile Asp Arg Cys Leu Val Gly Pro Arg Ala Pro 
65                  70                  75                  80  


Ala Pro Arg Asp Pro Gly Asp Ser Glu Glu Leu Thr Arg Phe Pro Gly 
                85                  90                  95      


Leu Arg Gly Pro Thr Gly Gln Lys Val Val Arg Phe Gly Asp Glu Asp 
            100                 105                 110         


Leu Thr Trp Gln Asp Glu His Ser Ala Pro Phe Ser Trp Glu Thr Lys 
        115                 120                 125             


Ser Gln Met Glu Phe Ser Ile Ser Ala Leu Ser Ile Gln Glu Pro Ser 
    130                 135                 140                 


Asn Gly Thr Ala Ala Ser Glu Pro Arg Pro Leu Ser Lys Ala Ser Gln 
145                 150                 155                 160 


Gly Ser Gln Ala Leu Lys Ser Ser Gln Gly Ser Arg Ser Ser Ser Leu 
                165                 170                 175     


Asp Ala Leu Gly Pro Thr Arg Lys Glu Glu Glu Ala Ser Phe Trp Lys 
            180                 185                 190         


Ile Asn Ala Glu Arg Ser Arg Gly Glu Gly Pro Glu Ala Glu Phe Gln 
        195                 200                 205             


Ser Leu Thr Pro Ser Gln Ile Lys Ser Met Glu Lys Gly Glu Lys Val 
    210                 215                 220                 


Leu Pro Pro Cys Tyr Arg Gln Glu Pro Ala Pro Lys Asp Arg Glu Ala 
225                 230                 235                 240 


Lys Val Glu Arg Pro Ser Thr Leu Arg Gln Glu Gln Arg Pro Leu Pro 
                245                 250                 255     


Asn Val Ser Thr Glu Arg Glu Arg Pro Gln Pro Val Gln Ala Phe Ser 
            260                 265                 270         


Ser Ala Leu His Glu Ala Ala Pro Ser Gln Leu Glu Gly Lys Leu Pro 
        275                 280                 285             


Ser Pro Asp Val Arg Gln Asp Asp Gly Glu Asp Thr Leu Phe Ser Glu 
    290                 295                 300                 


Pro Lys Phe Ala Gln Val Ser Ser Ser Asn Val Val Leu Lys Thr Gly 
305                 310                 315                 320 


Phe Asp Phe Leu Asp Asn Trp 
                325         

<210>  86
<211>  16365
<212>  DNA
<213>  Homo sapiens

<400>  86
gcgcggcccc ctccagcccc cggctcccgg cagcagaagc agaaggcagc gccaggggcc     60

gccgccgccg ccgagctccg cggggctcgg gagccggccc cggcgaggag gcgcggaacc    120

atggccgatg ggggcgaggg cgaagacgag atccagttcc tgcgaactga tgatgaagtg    180

gttctgcagt gcaccgcaac catccacaaa gaacaacaga agctatgctt ggcagcagaa    240

ggatttggca acagactttg tttcttggag tccacttcca attccaagaa tgtgccccca    300

gacctctcca tctgcacctt tgtgctggag cagtccctct ctgtccgggc gctgcaggag    360

atgctggcta acaccgtgga gaaatcagaa gggcaagttg atgtggaaaa atggaaattc    420

atgatgaaga ctgctcaagg tggtggtcat cgaacactcc tctacggaca tgccatattg    480

ctgcgccatt cctatagtgg catgtatctg tgctgcctgt ccacctcccg gtcttcaact    540

gataagctgg cttttgatgt tggcttgcaa gaggacacca caggggaggc ttgttggtgg    600

accatacacc ctgcctctaa gcagcgatca gaaggagaaa aagtacgagt tggagatgac    660

ctcatcttag ttagcgtgtc ctctgaaagg tacttgcact tgtcttatgg caacggcagc    720

ttacacgtgg atgccgcttt ccagcagact ctctggagcg tggccccaat cagctcagga    780

agtgaggcag cccaagggta tctcattggt ggtgatgtcc tcaggttgct gcatggacac    840

atggacgagt gtctcactgt cccttcagga gaacatggtg aagagcagcg gagaactgtt    900

cattatgaag gtggcgctgt gtctgttcat gcacgttccc tttggagact agagacgcta    960

agagttgcgt ggagtggaag ccacataaga tggggacagc cattccgact acgccatgtc   1020

acaacaggaa aatacttgag tctcatggaa gacaaaaacc ttctactcat ggacaaagag   1080

aaagctgatg taaaatcaac agcatttacc ttccggtctt ccaaggaaaa attggatgta   1140

ggggtgagaa aagaagtaga tggcatggga acatctgaaa taaaatacgg tgactcagta   1200

tgctatatac aacatgtaga cacaggccta tggcttactt accagtctgt ggacgtgaaa   1260

tccgtgagaa tgggatctat acaacgtaag gctattatgc atcatgaagg ccacatggat   1320

gatggcataa gtttgtcgag atcccagcat gaagaatcac gcacagcccg agttatccgg   1380

agcacagtct tccttttcaa tagatttata aggggccttg atgctctcag caagaaagcg   1440

aaggcttcca cagtcgattt gcctatagag tccgtaagcc taagtctgca ggatctcatt   1500

ggctacttcc accccccaga tgagcattta gagcatgaag acaaacagaa cagactacga   1560

gccctgaaga atcggcaaaa tctcttccag gaagagggaa tgatcaacct cgtgcttgag   1620

tgcatagacc gtttgcacgt ctacagcagt gcagcacact ttgctgatgt tgctgggcga   1680

gaagcaggag agtcttggaa atccattctg aattctctgt atgagttgct ggcggctcta   1740

attagaggaa atcgtaaaaa ctgtgctcaa ttttctggct ccctcgactg gttgatcagc   1800

agattggaaa gactggaagc ttcttcaggc attctggaag ttttacactg tgttttagta   1860

gaaagtccag aagctctaaa tattattaaa gaaggacata ttaaatctat tatctcactt   1920

ttagacaaac atggaagaaa tcacaaggtt ctggatgtct tgtgctcact ctgtgtttgc   1980

cacggggttg cagtccgttc taaccagcat ctcatctgtg acaatctcct accaggaaga   2040

gacttgttat tgcagacacg tcttgtgaac catgtcagca gcatgagacc caatattttt   2100

ctgggcgtca gtgaaggttc tgctcagtat aagaaatggt actatgaatt gatggtggac   2160

cacacagagc cctttgtgac agctgaagca actcacctgc gagtgggctg ggcttccact   2220

gaaggatatt ctccctaccc tggagggggc gaagagtggg gtggaaatgg tgttggagat   2280

gatctcttct cctatggatt tgatggcctt catctctggt caggttgtat tgctcgtact   2340

gtaagctcac caaaccaaca tctgttaaga actgatgatg tcatcagttg ctgtttagat   2400

ctgagtgccc caagcatctc gttccgaatt aatggacaac ctgttcaagg aatgtttgag   2460

aatttcaaca tcgatggcct cttctttcca gtcgttagtt tctctgcagg aataaaagta   2520

cgctttctgc ttggagggcg acatggagaa ttcaaatttc ttcctccacc tgggtatgct   2580

ccttgttatg aagctgttct gccaaaagaa aagttgaaag tggaacacag ccgagagtac   2640

aagcaagaaa gaacttacac acgcgacctg ctgggcccca cagtttccct gacgcaagct   2700

gccttcacac ccatccctgt ggataccagc cagatcgtgt tgcctcctca tctagaaaga   2760

ataagagaaa aactggcaga gaatatccat gaactctggg ttatgaataa aattgagctt   2820

ggctggcagt atggtccggt tagagatgac aacaagagac aacacccatg cctggtggag   2880

ttctccaagc tgcctgaaca ggagcgcaat tacaacttac aaatgtcgct tgagaccctg   2940

aagactttgt tggcattagg atgtcatgtg ggtatatcag atgaacatgc tgaagacaag   3000

gtgaaaaaaa tgaagctacc caagaattac cagctgacaa gtggatacaa gcctgcccct   3060

atggacctga gctttatcaa actcacccca tcacaagaag caatggtgga caagttggca   3120

gaaaatgcac ataatgtgtg ggcgcgggat cgaatccggc agggctggac ttatggcatc   3180

caacaggacg taaagaacag aagaaatcct cgccttgttc cctacactct tctggatgac   3240

cgaaccaaga aatccaacaa ggacagcctc cgcgaggctg tgcgcacgct gctggggtac   3300

ggctacaact tggaagcacc agatcaagat catgcagcca gagccgaagt gtgcagcggc   3360

accggggaaa ggttccgaat cttccgtgcc gagaagacct atgcagtgaa ggccggacgg   3420

tggtattttg aatttgagac ggtcactgct ggagacatga gggttggttg gagtcgtcct   3480

ggttgtcaac cggatcagga gcttggctca gatgaacgtg cctttgcctt tgatggcttc   3540

aaggcccagc ggtggcatca gggcaatgaa cactatgggc gctcttggca agcaggcgat   3600

gtcgtggggt gtatggttga catgaacgaa cacaccatga tgttcacact gaatggtgaa   3660

atccttcttg atgattcagg ctcagaactg gctttcaagg actttgatgt tggcgatgga   3720

ttcatacctg tgtgtagcct tggagtggct caagtgggta ggatgaactt tggaaaggat   3780

gtcagcacct tgaaatattt caccatctgt ggcttacaag agggctatga accatttgcc   3840

gttaatacaa acagggatat taccatgtgg ctgagcaaga ggcttcctca gtttcttcaa   3900

gttccatcaa accatgaaca tatagaggtg accagaatag acggcaccat agacagttcc   3960

ccatgtttaa aggtcactca gaagtctttt ggttctcaga acagcaacac tgatatcatg   4020

ttttatcgcc tgagcatgcc gatcgagtgc gcggaggtct tctccaagac ggtggctgga   4080

gggctccctg gggctggcct ttttgggccc aagaatgact tggaagatta tgatgctgat   4140

tctgactttg aggttctgat gaagacagct catggccatc tagtgcccga tcgtgttgac   4200

aaagacaaag aagctactaa accagagttt aacaaccaca aagattatgc ccaggaaaag   4260

ccctctcgtc tgaaacaaag atttttgctt agaagaacaa agccagatta cagcacaagc   4320

cattctgcaa gactcaccga agatgtcctt gctgatgatc gggatgacta tgatttcttg   4380

atgcaaacgt ccacgtacta ttactcagtg agaatctttc ctggacaaga acctgctaat   4440

gtctgggtgg gctggattac atcagatttc catcagtatg acacaggctt tgacttggac   4500

agagttcgca cagtaacagt tactctagga gatgaaaaag gaaaagtgca tgaaagcatc   4560

aaacgcagca actgctatat ggtatgtgcg ggtgagagca tgagccccgg gcaaggacgc   4620

aacaataatg gactggagat tggctgtgtg gtggatgctg ccagcgggct gctcacattc   4680

attgccaatg gcaaggaact gagcacatac tatcaggtgg aaccgagtac aaaattattt   4740

cctgcggttt ttgcacaagc tacaagtccc aatgttttcc agtttgagtt gggaagaata   4800

aagaatgtga tgcctctctc ggcgggatta ttcaagagtg agcacaagaa ccccgtgccg   4860

cagtgccccc cgcgcctcca cgtgcagttc ctgtcacacg tcctgtggag cagaatgccc   4920

aaccagtttt tgaaggtaga tgtgtctcga ataagtgaac gccaaggctg gttggtgcag   4980

tgtttggatc ctctgcagtt catgtctctt catatccctg aggaaaacag atctgttgac   5040

atcttagagt tgacagagca ggaggaattg ctgaaatttc actatcacac tctccggctc   5100

tactcagccg tctgtgctct tgggaaccac cgggtggccc atgccctgtg cagccatgtg   5160

gatgaacctc agctcctcta tgccattgag aacaagtaca tgcctggttt gctgcgtgct   5220

ggctactatg acctgctgat tgacatccac ctgagctcct atgccactgc caggctcatg   5280

atgaacaacg agtacattgt ccccatgacg gaggagacga agagcatcac cctgttccct   5340

gatgagaaca aaaaacacgg ccttccaggg atcggcctca gcacctccct caggccacgg   5400

atgcagtttt cctcccccag ttttgtaagc attagtaatg aatgttacca gtacagtcca   5460

gagttcccac tggacatcct caagtccaaa accatacaga tgctgacaga agctgttaaa   5520

gagggcagtc ttcatgcccg ggacccagtt ggagggacta ctgaattcct ctttgtacct   5580

ctcatcaagc ttttctatac cctgctgatc atgggcatct ttcacaacga ggacttgaag   5640

cacatcttgc agttgattga gcccagtgtg tttaaagaag ctgccactcc ggaggaggag   5700

agtgacacgc tggagaaaga gctcagtgtg gacgatgcaa agctgcaagg agctggtgag   5760

gaagaagcca aggggggcaa gcggcccaag gaaggcctgc tccaaatgaa actgccagag   5820

ccagttaaat tgcagatgtg cctactgctt cagtacctct gtgactgcca ggtccggcac   5880

cggatagaag ccattgtagc cttttcagat gattttgtgg ctaagctcca agacaatcaa   5940

cgtttccgat acaacgaagt catgcaagcc ttaaacatgt cagctgcact cacagccagg   6000

aagacaaagg aatttagatc accacctcaa gaacagatca atatgcttct caattttaag   6060

gatgacaaaa gtgaatgtcc atgtccagaa gaaattcgtg accaactatt ggatttccat   6120

gaagatttga tgacacattg tggaattgag ctggatgaag atgggtctct ggatggaaac   6180

agtgatttaa caattagagg gcgtctgcta tccctggtag aaaaggtgac atatctgaag   6240

aagaagcaag cagaaaaacc agttgagagt gactccaaaa agtcctccac tctgcagcag   6300

ctgatttctg agaccatggt ccgatgggct caggagtctg tcattgaaga ccccgagctg   6360

gtgagggcca tgtttgtgtt gctccatcgg cagtatgacg gcattggggg tcttgttcgg   6420

gccctgccaa agacctacac gataaatggt gtgtccgtgg aggacaccat caacctgctg   6480

gcatcccttg gtcagattcg gtccctgctg agtgtgagaa tgggcaaaga agaagagaag   6540

ctcatgattc gtggattagg ggatattatg aataacaaag tgttttacca gcaccctaat   6600

ctcatgaggg cactggggat gcacgagact gtgatggagg tcatggtgaa cgtccttgga   6660

ggtggagagt ccaaggaaat cacctttccc aagatggtgg ccaactgttg ccgttttctc   6720

tgttacttct gtcgtataag taggcagaat caaaaagcta tgtttgatca tctcagttat   6780

ttactggaaa acagcagtgt tggtcttgcc tccccagcta tgagaggttc aacaccactg   6840

gatgtggctg cagcttcggt gatggataat aatgaactag cattagctct gcgtgagccg   6900

gatctagaaa aggtagttcg ttatttggct ggttgtggac tgcaaagttg ccagatgctg   6960

gtgtctaagg gctatccaga cattgggtgg aacccagttg aaggagagag atatcttgac   7020

tttcttagat ttgctgtctt ctgtaatggg gagagtgtgg aggaaaatgc aaatgtcgtg   7080

gtgagattgc tcattcggag gcctgagtgt tttggtcctg ctttgagagg agaaggtggg   7140

aatgggcttc ttgcagcaat ggaagaagcc atcaaaatcg ccgaggatcc ttcccgagat   7200

ggtccctcac caaatagcgg atccagtaaa acacttgaca cagaggagga ggaagatgac   7260

actatccaca tggggaacgc gatcatgacc ttctattcag ctttgattga cctcttggga   7320

cgctgtgctc ctgagatgca tttgattcat gccgggaagg gagaagccat cagaattagg   7380

tccattttga gatccctcat tcccctggga gatttggtgg gcgttatcag catcgctttt   7440

cagatgccaa caatagccaa agatgggaat gtggtggaac ctgacatgtc tgcggggttt   7500

tgcccagatc acaaggcagc catggtttta ttccttgaca gggtctatgg gattgaggtt   7560

caagacttcc tcctccatct tcttgaggtt ggctttctgc cagatctccg ggcggctgct   7620

tctttagata cggcagcttt gagtgctaca gacatggcct tggccctcaa tcggtacctt   7680

tgcacagccg tcttgccatt gttaacaaga tgtgctcctc tctttgctgg cacagagcac   7740

cacgcttctc tcattgactc attacttcat actgtgtata gactttctaa gggctgttca   7800

cttaccaaag ctcagcggga ttccatagaa gtttgtttac tctctatttg tggacaactg   7860

agaccttcta tgatgcagca cttactcaga agattagtat ttgatgttcc attattaaat   7920

gaacacgcaa agatgcctct taaactgctg acaaatcatt atgaaagatg ctggaaatat   7980

tactgcctgc ctggagggtg gggaaacttt ggtgctgcct cagaagaaga acttcattta   8040

tcaagaaagt tgttctgggg catttttgat gccctgtctc aaaagaaata tgaacaagaa   8100

cttttcaaac tggcactgcc ttgcctgagt gcagttgcgg gagctttgcc tccagactac   8160

atggagtcaa attatgtcag tatgatggaa aaacagtcat caatggattc tgaagggaac   8220

tttaacccac aacctgttga tacctcaaat attacaattc ctgagaaatt ggaatacttc   8280

attaacaaat atgcagaaca ctcccatgac aaatggtcaa tggacaagtt ggcaaatgga   8340

tggatttatg gagaaatata ttcagactct tctaaggttc agccattaat gaagccatat   8400

aagctattgt ctgaaaagga aaaagaaatt tatcgctggc caatcaaaga atctttaaaa   8460

actatgctgg cttggggctg gagaattgaa agaactcggg agggagacag catggccctt   8520

tacaaccgga ctcgtcgtat ttctcagaca agccaggttt ctgtggacgc tgcccatggt   8580

tacagtcccc gggccattga catgagcaat gttacactat ctagagacct gcatgctatg   8640

gcagaaatga tggctgaaaa ctaccataat atatgggcaa agaaaaagaa aatggagttg   8700

gagtccaaag gaggaggaaa ccatcctctg ctggtgccct atgatacact gacagccaaa   8760

gagaaagcca aggatagaga aaaagcacag gacatcctca agttcttgca gatcaatgga   8820

tatgctgtat ccagaggatt taaggacctg gaactggaca cgccttctat tgagaaacga   8880

tttgcctata gtttcctcca acaactcatt cgctatgtgg atgaagccca tcagtatatc   8940

ctggagtttg atggtggcag cagaggcaaa ggagaacatt tcccttatga acaagaaatc   9000

aagttctttg caaaagtcgt tcttccttta attgatcagt atttcaaaaa ccatcgttta   9060

tacttcttat ctgcagcaag cagacctctc tgctctggag gacatgcttc caacaaagag   9120

aaagaaatgg tgactagcct attctgcaaa cttggagttc ttgtcaggca taggatttca   9180

ctatttggca atgatgcaac atcaattgtc aactgtcttc atattttggg tcagactttg   9240

gatgcaagga cagtgatgaa gactggcctg gagagtgtta aaagtgcact cagagctttt   9300

ctggacaacg ctgcagagga tctggagaag accatggaaa acctcaagca gggccagttc   9360

actcacaccc gaaaccagcc caaaggggtt actcagatta tcaattacac cacagtggcc   9420

ctgctgccaa tgctgtcttc attatttgaa catattggcc agcatcagtt cggagaagac   9480

ctaatattgg aagatgtcca ggtgtcttgt tatagaattc tgactagctt atatgctttg   9540

ggaaccagca agagtattta cgtggagagg caacgttctg cattaggaga atgtctagct   9600

gcctttgctg gtgcttttcc tgtagcattt ttggaaactc atctggacaa acataatatt   9660

tactccatct acaataccaa gtcttcacga gaaagagcag ctctcagttt gccaactaat   9720

gtggaagatg tttgtccaaa cataccgtct ttggagaaac tcatggaaga aatcgtggaa   9780

ttagccgagt ccggcattcg ctacactcaa atgccacatg tcatggaagt catactgccc   9840

atgctttgca gctacatgtc tcgttggtgg gagcatggac ctgagaacaa tccagaacgg   9900

gccgagatgt gctgcacagc cctgaactca gagcacatga acacacttct agggaacata   9960

ttgaaaatca tatataataa cttggggatt gatgagggag cctggatgaa gaggctagca  10020

gtgttttccc agcctataat aaataaagtg aaacctcagc tcttgaaaac tcatttcttg  10080

ccgttaatgg agaaactcaa gaaaaaggca gctacggtgg tgtctgagga agaccacctg  10140

aaagctgagg ccagggggga catgtcggag gcagaactcc tcatcctaga tgagttcacc  10200

acactggcca gagatctcta tgccttctac cctctcttga ttagatttgt ggactataac  10260

agggcaaagt ggctaaagga gcctaaccca gaagcagagg agctcttccg catggtggct  10320

gaagtgttta tctactggtc gaagtcccat aatttcaaaa gagaagagca gaacttcgtt  10380

gtacagaatg aaatcaacaa tatgtctttc cttattactg ataccaagtc aaagatgtca  10440

aaggcagctg tttctgatca ggaaaggaag aaaatgaagc gcaaaggaga tcggtattcc  10500

atgcagacct ctctgattgt agcagctctg aagcggttac tgcccattgg gttgaacatc  10560

tgtgcccctg gggaccagga gctcattgct ctggccaaaa atcgatttag cctgaaagat  10620

accgaggatg aagtacgaga tataatccgc agcaatattc atttacaagg caagttggag  10680

gatcctgcta ttagatggca aatggctctt tacaaagact taccaaacag gactgatgat  10740

acctcagatc cagagaagac ggtagaaaga gtattggata tagcaaatgt gctttttcat  10800

cttgaacaga agtctaaacg tgtgggtcgg agacattact gtctggtgga acatcctcag  10860

agatctaaaa aggctgtatg gcataaacta ctgtccaagc agaggaaaag ggctgttgta  10920

gcctgcttcc ggatggcccc cttatataat ctgccaaggc atcgggctgt caatctcttt  10980

cttcagggat atgaaaagtc ttggattgaa acagaagaac attactttga agataaactg  11040

atagaagatt tagcaaaacc tggggctgaa cctccagaag aagatgaagg cactaagaga  11100

gttgatcctc tacatcagct gatccttctg tttagtcgga cagctttaac agagaaatgc  11160

aaactggagg aagatttttt atatatggcc tatgcagata ttatggcaaa gagttgtcat  11220

gatgaggaag atgacgatgg tgaagaggaa gtgaagagtt ttgaagaaaa agaaatggaa  11280

aagcaaaagc ttctatacca gcaagcccga ctccacgatc gtggcgcggc tgagatggtg  11340

ctacagacaa tcagtgccag caaaggtgaa actggaccaa tggtagcagc tactctgaaa  11400

cttggaattg ctattttaaa tggtgggaac tccacagtac agcagaaaat gcttgactac  11460

ctcaaggaga aaaaggatgt gggcttcttt cagagcctgg ccggcctgat gcagtcatgt  11520

agtgtccttg acctaaatgc atttgagcga caaaacaaag ctgaaggtct tgggatggtg  11580

acagaggaag gatcaggaga aaaggttctg caggacgatg agttcacctg tgacctcttc  11640

cgattcctgc aactactctg tgagggacac aactcagatt ttcagaatta tctgagaact  11700

cagactggca ataatacaac tgtcaacata attatctcca ctgtagacta cctactgaga  11760

gttcaggaat caattagtga cttttattgg tattactctg ggaaagatgt tattgatgaa  11820

caaggacaac ggaatttctc caaagctatc caagtggcaa aacaagtctt taacactctt  11880

acagagtata ttcagggtcc ttgcactggg aatcaacaga gtttggcaca cagcaggctg  11940

tgggatgctg tggtcggctt tcttcatgtg tttgcccata tgcagatgaa gctgtcgcag  12000

gattccagtc aaattgagct attaaaagaa ttaatggatc tgcagaagga tatggtggtc  12060

atgttgctgt ccatgttaga aggtaatgtt gttaatggaa cgattggcaa acagatggtg  12120

gatatgcttg tggaatcttc caacaacgtg gagatgattc tcaaattttt tgacatgttc  12180

ttaaaactaa aggatttgac gtcgtctgat acttttaaag aatatgaccc cgatggcaag  12240

ggagtcattt ccaagaggga cttccacaaa gcgatggaga gccataagca ctacacgcag  12300

tcagaaacgg aatttctttt gtcttgtgcg gagacggatg agaatgaaac cctcgactac  12360

gaagagttcg tcaaacgctt ccacgaacct gcgaaggaca tcggcttcaa cgtcgccgtc  12420

cttctgacaa acctctctga gcacatgccc aacgataccc gacttcagac ttttctggaa  12480

ttagcagaga gcgtcctgaa ttatttccag ccctttctgg gccgcatcga aatcatggga  12540

agcgccaaac gcatcgagag ggtctatttt gaaatcagtg agtccagccg aacccagtgg  12600

gagaagcccc aggtcaagga gtccaaaaga cagttcatat ttgacgtggt caacgaaggc  12660

ggagagaaag agaagatgga actctttgtg aacttctgcg aggacaccat ctttgaaatg  12720

cagctggcgg ctcagatctc ggagtcggac ttgaacgaga ggtcagcgaa taaggaagaa  12780

agcgagaagg agaggccgga agagcagggg ccgaggatgg ctttcttctc cattctgacg  12840

gtcaggtcgg ccctgtttgc gctcaggtac aatatcttga cccttatgcg aatgctcagt  12900

ctgaagagcc tgaagaagca gatgaaaaaa gtaaaaaaga tgaccgtgaa ggacatggtc  12960

acggccttct tttcatccta ctggagtatt ttcatgaccc tcttgcactt cgtggccagc  13020

gttttcagag gctttttccg catcatttgc agcctgctgc ttgggggaag cctcgtcgaa  13080

ggtgctaaaa agatcaaagt tgcagaactg ttagccaaca tgccagaccc cactcaggat  13140

gaggttagag gagatgggga ggagggagag aggaaacccc tggaagccgc cctgccctcc  13200

gaggatctga ccgacttaaa ggagctgaca gaggaaagtg accttctttc ggacatcttt  13260

ggcctggatc tgaagagaga aggaggacag tacaaactga ttcctcataa tccaaatgct  13320

gggctcagtg acctcatgag caacccagtc cccatgcctg aggtgcagga aaaatttcag  13380

gaacagaagg caaaagaaga agaaaaggaa gaaaaagaag aaaccaaatc tgaacctgaa  13440

aaagccgagg gagaagatgg agaaaaagaa gagaaagcca aggaagacaa gggcaaacaa  13500

aagttgaggc agcttcacac acacagatac ggagaaccag aagtgccaga gtcagcattc  13560

tggaagaaaa tcatagcata tcaacagaaa cttctaaact attttgctcg caacttttac  13620

aacatgagaa tgttagcctt atttgtcgca tttgctatca atttcatctt gctcttttat  13680

aaggtctcca cttcttctgt ggttgaagga aaggagctcc ccacgagaag ttcaagtgaa  13740

aatgccaaag tgacaagcct ggacagcagc tcccatagaa tcatcgcagt tcactatgta  13800

ctagaggaga gcagcggcta catggagccc acgttgcgta tcttagctat tctgcacacg  13860

gtcatttctt tcttctgcat cattggatac tactgcttga aagtcccatt ggttattttt  13920

aagcgagaaa aggaagtggc acggaaattg gaatttgatg ggctttatat tacagaacag  13980

ccttcagaag atgatattaa aggccagtgg gatagactcg taatcaacac acagtcattt  14040

cccaacaact actgggacaa atttgttaaa agaaaggtta tggataaata tggagagttc  14100

tacggccgag acagaatcag tgaattactt ggcatggaca aggcagctct ggacttcagt  14160

gatgccagag aaaagaagaa gccaaagaaa gacagctcct tatcagctgt actgaactcc  14220

attgatgtga agtatcagat gtggaaacta ggagtcgttt tcactgacaa ctccttcctc  14280

tacctagcct ggtatatgac tatgtctgtt cttggacact ataacaactt tttttttgcc  14340

gctcaccttc tcgacattgc tatgggattc aagacattaa gaaccatctt gtcctcagta  14400

actcacaatg gcaaacagct cgtattaacc gttggcttat tagctgttgt tgtataccta  14460

tacactgtgg tggcattcaa ttttttccga aaattctaca ataaaagtga agatggtgat  14520

acaccagata tgaaatgtga cgatatgcta acatgctata tgttccacat gtatgttgga  14580

gttcgtgctg gaggagggat cggggatgaa atcgaagacc cagcaggaga tgaatatgag  14640

atctatcgaa tcatctttga catcactttc ttcttctttg ttattgtcat tctcttggcc  14700

ataatacaag gtctaattat tgatgctttt ggagaactaa gagaccaaca ggaacaagtc  14760

aaagaagaca tggagaccaa atgcttcatc tgtgggatag gcaatgatta cttcgacaca  14820

gtgccacatg gctttgaaac ccacacttta caggagcaca acttggctaa ttacttgttt  14880

tttctgatgt atcttataaa caaagatgaa acagaacaca caggacagga atcttatgtc  14940

tggaagatgt atcaagaaag gtgttgggaa tttttcccag caggggattg cttccggaaa  15000

cagtatgaag accagctaaa ttaaactcag acccaatcac ctctaaaaac caaaacccta  15060

cccctctctc tccctctctc aatttctctg ctctcttgga aacattttgc tgattttgtg  15120

aattgccagc gttgtgtgtt ttctgggagc atcgaagctc tgtttcggaa gagctgtttc  15180

ctccccccac cttttgtatt tactttgaga ctaaagactg aagaataatc taaattcata  15240

ctcagacaaa aaaaggaatt ctggaaagaa aaccattctg gacactgtca taacacacat  15300

agatagattt tcttctgaga ctcccggagt cttctcgagc tacgagacct tcacagagac  15360

acgtggcagc cacactcacc cagcctcttt atttcaccat cctggaagga aactgtctgt  15420

ctaatggtca cagagcactg tagcacttaa cagattgcca tggacaccag ttgcgaaggg  15480

aaatagtgcc ttactatatg tgggttgagc tatgcagaag atacgtgcat gaaaaaacat  15540

ctttattttc tttatgtcga cctttctttt cttagattga ttttgtgagg tttttttttt  15600

ttcctttagt cttttcttta gtgggggagg gtaagaaaag cagtttgcac ttaaaaagaa  15660

aaaaaaaaaa cgggtggtgt gtctcaggac aaaaggaggc tcttctcatt cagctaaatt  15720

cacatttgcc cccccccccc gcccccgccc ccatatgctc ctgctattat tttggtaatg  15780

ctctgatgca acattgcaac tttatgaaat ctttgtatga aaacaaaaag actgcaaaaa  15840

atacactttc aaaagaaacc attcattgca tgtttattat gcaagtttaa atgaacaaag  15900

aaaaccttca gaaacaagtt gatcaacgtg agagaaattt catgataatt attcatagta  15960

ataaagtgtc gtgggcttaa ttgtatatct ggagccagtg tcatccacca acaatgtgat  16020

acaatatgaa cttgacagta gttttgggtt ttgctcattc tttcagccac ctgtgatcag  16080

ttttgttgat taaggacttc ttgtcaggcc attttttaat atcaaagctg aagcaatatc  16140

cattcaggga tttcatcagt tgcatcacaa aacacggatg ataatataca tcactccatt  16200

ttttccattt tgagtccttt taaatgtaat gctaaccttt acaattaaaa agtcagattc  16260

agaatggaaa caaggtcatt ttgcaaacat tggagctctt ttattacaag tctgcttgtt  16320

aattttagaa ctgtaaaacc gctctgatta aactatttaa ctaac                  16365


<210>  87
<211>  4967
<212>  PRT
<213>  Homo sapiens

<400>  87


Met Ala Asp Gly Gly Glu Gly Glu Asp Glu Ile Gln Phe Leu Arg Thr 
1               5                   10                  15      


Asp Asp Glu Val Val Leu Gln Cys Thr Ala Thr Ile His Lys Glu Gln 
            20                  25                  30          


Gln Lys Leu Cys Leu Ala Ala Glu Gly Phe Gly Asn Arg Leu Cys Phe 
        35                  40                  45              


Leu Glu Ser Thr Ser Asn Ser Lys Asn Val Pro Pro Asp Leu Ser Ile 
    50                  55                  60                  


Cys Thr Phe Val Leu Glu Gln Ser Leu Ser Val Arg Ala Leu Gln Glu 
65                  70                  75                  80  


Met Leu Ala Asn Thr Val Glu Lys Ser Glu Gly Gln Val Asp Val Glu 
                85                  90                  95      


Lys Trp Lys Phe Met Met Lys Thr Ala Gln Gly Gly Gly His Arg Thr 
            100                 105                 110         


Leu Leu Tyr Gly His Ala Ile Leu Leu Arg His Ser Tyr Ser Gly Met 
        115                 120                 125             


Tyr Leu Cys Cys Leu Ser Thr Ser Arg Ser Ser Thr Asp Lys Leu Ala 
    130                 135                 140                 


Phe Asp Val Gly Leu Gln Glu Asp Thr Thr Gly Glu Ala Cys Trp Trp 
145                 150                 155                 160 


Thr Ile His Pro Ala Ser Lys Gln Arg Ser Glu Gly Glu Lys Val Arg 
                165                 170                 175     


Val Gly Asp Asp Leu Ile Leu Val Ser Val Ser Ser Glu Arg Tyr Leu 
            180                 185                 190         


His Leu Ser Tyr Gly Asn Gly Ser Leu His Val Asp Ala Ala Phe Gln 
        195                 200                 205             


Gln Thr Leu Trp Ser Val Ala Pro Ile Ser Ser Gly Ser Glu Ala Ala 
    210                 215                 220                 


Gln Gly Tyr Leu Ile Gly Gly Asp Val Leu Arg Leu Leu His Gly His 
225                 230                 235                 240 


Met Asp Glu Cys Leu Thr Val Pro Ser Gly Glu His Gly Glu Glu Gln 
                245                 250                 255     


Arg Arg Thr Val His Tyr Glu Gly Gly Ala Val Ser Val His Ala Arg 
            260                 265                 270         


Ser Leu Trp Arg Leu Glu Thr Leu Arg Val Ala Trp Ser Gly Ser His 
        275                 280                 285             


Ile Arg Trp Gly Gln Pro Phe Arg Leu Arg His Val Thr Thr Gly Lys 
    290                 295                 300                 


Tyr Leu Ser Leu Met Glu Asp Lys Asn Leu Leu Leu Met Asp Lys Glu 
305                 310                 315                 320 


Lys Ala Asp Val Lys Ser Thr Ala Phe Thr Phe Arg Ser Ser Lys Glu 
                325                 330                 335     


Lys Leu Asp Val Gly Val Arg Lys Glu Val Asp Gly Met Gly Thr Ser 
            340                 345                 350         


Glu Ile Lys Tyr Gly Asp Ser Val Cys Tyr Ile Gln His Val Asp Thr 
        355                 360                 365             


Gly Leu Trp Leu Thr Tyr Gln Ser Val Asp Val Lys Ser Val Arg Met 
    370                 375                 380                 


Gly Ser Ile Gln Arg Lys Ala Ile Met His His Glu Gly His Met Asp 
385                 390                 395                 400 


Asp Gly Ile Ser Leu Ser Arg Ser Gln His Glu Glu Ser Arg Thr Ala 
                405                 410                 415     


Arg Val Ile Arg Ser Thr Val Phe Leu Phe Asn Arg Phe Ile Arg Gly 
            420                 425                 430         


Leu Asp Ala Leu Ser Lys Lys Ala Lys Ala Ser Thr Val Asp Leu Pro 
        435                 440                 445             


Ile Glu Ser Val Ser Leu Ser Leu Gln Asp Leu Ile Gly Tyr Phe His 
    450                 455                 460                 


Pro Pro Asp Glu His Leu Glu His Glu Asp Lys Gln Asn Arg Leu Arg 
465                 470                 475                 480 


Ala Leu Lys Asn Arg Gln Asn Leu Phe Gln Glu Glu Gly Met Ile Asn 
                485                 490                 495     


Leu Val Leu Glu Cys Ile Asp Arg Leu His Val Tyr Ser Ser Ala Ala 
            500                 505                 510         


His Phe Ala Asp Val Ala Gly Arg Glu Ala Gly Glu Ser Trp Lys Ser 
        515                 520                 525             


Ile Leu Asn Ser Leu Tyr Glu Leu Leu Ala Ala Leu Ile Arg Gly Asn 
    530                 535                 540                 


Arg Lys Asn Cys Ala Gln Phe Ser Gly Ser Leu Asp Trp Leu Ile Ser 
545                 550                 555                 560 


Arg Leu Glu Arg Leu Glu Ala Ser Ser Gly Ile Leu Glu Val Leu His 
                565                 570                 575     


Cys Val Leu Val Glu Ser Pro Glu Ala Leu Asn Ile Ile Lys Glu Gly 
            580                 585                 590         


His Ile Lys Ser Ile Ile Ser Leu Leu Asp Lys His Gly Arg Asn His 
        595                 600                 605             


Lys Val Leu Asp Val Leu Cys Ser Leu Cys Val Cys His Gly Val Ala 
    610                 615                 620                 


Val Arg Ser Asn Gln His Leu Ile Cys Asp Asn Leu Leu Pro Gly Arg 
625                 630                 635                 640 


Asp Leu Leu Leu Gln Thr Arg Leu Val Asn His Val Ser Ser Met Arg 
                645                 650                 655     


Pro Asn Ile Phe Leu Gly Val Ser Glu Gly Ser Ala Gln Tyr Lys Lys 
            660                 665                 670         


Trp Tyr Tyr Glu Leu Met Val Asp His Thr Glu Pro Phe Val Thr Ala 
        675                 680                 685             


Glu Ala Thr His Leu Arg Val Gly Trp Ala Ser Thr Glu Gly Tyr Ser 
    690                 695                 700                 


Pro Tyr Pro Gly Gly Gly Glu Glu Trp Gly Gly Asn Gly Val Gly Asp 
705                 710                 715                 720 


Asp Leu Phe Ser Tyr Gly Phe Asp Gly Leu His Leu Trp Ser Gly Cys 
                725                 730                 735     


Ile Ala Arg Thr Val Ser Ser Pro Asn Gln His Leu Leu Arg Thr Asp 
            740                 745                 750         


Asp Val Ile Ser Cys Cys Leu Asp Leu Ser Ala Pro Ser Ile Ser Phe 
        755                 760                 765             


Arg Ile Asn Gly Gln Pro Val Gln Gly Met Phe Glu Asn Phe Asn Ile 
    770                 775                 780                 


Asp Gly Leu Phe Phe Pro Val Val Ser Phe Ser Ala Gly Ile Lys Val 
785                 790                 795                 800 


Arg Phe Leu Leu Gly Gly Arg His Gly Glu Phe Lys Phe Leu Pro Pro 
                805                 810                 815     


Pro Gly Tyr Ala Pro Cys Tyr Glu Ala Val Leu Pro Lys Glu Lys Leu 
            820                 825                 830         


Lys Val Glu His Ser Arg Glu Tyr Lys Gln Glu Arg Thr Tyr Thr Arg 
        835                 840                 845             


Asp Leu Leu Gly Pro Thr Val Ser Leu Thr Gln Ala Ala Phe Thr Pro 
    850                 855                 860                 


Ile Pro Val Asp Thr Ser Gln Ile Val Leu Pro Pro His Leu Glu Arg 
865                 870                 875                 880 


Ile Arg Glu Lys Leu Ala Glu Asn Ile His Glu Leu Trp Val Met Asn 
                885                 890                 895     


Lys Ile Glu Leu Gly Trp Gln Tyr Gly Pro Val Arg Asp Asp Asn Lys 
            900                 905                 910         


Arg Gln His Pro Cys Leu Val Glu Phe Ser Lys Leu Pro Glu Gln Glu 
        915                 920                 925             


Arg Asn Tyr Asn Leu Gln Met Ser Leu Glu Thr Leu Lys Thr Leu Leu 
    930                 935                 940                 


Ala Leu Gly Cys His Val Gly Ile Ser Asp Glu His Ala Glu Asp Lys 
945                 950                 955                 960 


Val Lys Lys Met Lys Leu Pro Lys Asn Tyr Gln Leu Thr Ser Gly Tyr 
                965                 970                 975     


Lys Pro Ala Pro Met Asp Leu Ser Phe Ile Lys Leu Thr Pro Ser Gln 
            980                 985                 990         


Glu Ala Met Val Asp Lys Leu Ala  Glu Asn Ala His Asn  Val Trp Ala 
        995                 1000                 1005             


Arg Asp  Arg Ile Arg Gln Gly  Trp Thr Tyr Gly Ile  Gln Gln Asp 
    1010                 1015                 1020             


Val Lys  Asn Arg Arg Asn Pro  Arg Leu Val Pro Tyr  Thr Leu Leu 
    1025                 1030                 1035             


Asp Asp  Arg Thr Lys Lys Ser  Asn Lys Asp Ser Leu  Arg Glu Ala 
    1040                 1045                 1050             


Val Arg  Thr Leu Leu Gly Tyr  Gly Tyr Asn Leu Glu  Ala Pro Asp 
    1055                 1060                 1065             


Gln Asp  His Ala Ala Arg Ala  Glu Val Cys Ser Gly  Thr Gly Glu 
    1070                 1075                 1080             


Arg Phe  Arg Ile Phe Arg Ala  Glu Lys Thr Tyr Ala  Val Lys Ala 
    1085                 1090                 1095             


Gly Arg  Trp Tyr Phe Glu Phe  Glu Thr Val Thr Ala  Gly Asp Met 
    1100                 1105                 1110             


Arg Val  Gly Trp Ser Arg Pro  Gly Cys Gln Pro Asp  Gln Glu Leu 
    1115                 1120                 1125             


Gly Ser  Asp Glu Arg Ala Phe  Ala Phe Asp Gly Phe  Lys Ala Gln 
    1130                 1135                 1140             


Arg Trp  His Gln Gly Asn Glu  His Tyr Gly Arg Ser  Trp Gln Ala 
    1145                 1150                 1155             


Gly Asp  Val Val Gly Cys Met  Val Asp Met Asn Glu  His Thr Met 
    1160                 1165                 1170             


Met Phe  Thr Leu Asn Gly Glu  Ile Leu Leu Asp Asp  Ser Gly Ser 
    1175                 1180                 1185             


Glu Leu  Ala Phe Lys Asp Phe  Asp Val Gly Asp Gly  Phe Ile Pro 
    1190                 1195                 1200             


Val Cys  Ser Leu Gly Val Ala  Gln Val Gly Arg Met  Asn Phe Gly 
    1205                 1210                 1215             


Lys Asp  Val Ser Thr Leu Lys  Tyr Phe Thr Ile Cys  Gly Leu Gln 
    1220                 1225                 1230             


Glu Gly  Tyr Glu Pro Phe Ala  Val Asn Thr Asn Arg  Asp Ile Thr 
    1235                 1240                 1245             


Met Trp  Leu Ser Lys Arg Leu  Pro Gln Phe Leu Gln  Val Pro Ser 
    1250                 1255                 1260             


Asn His  Glu His Ile Glu Val  Thr Arg Ile Asp Gly  Thr Ile Asp 
    1265                 1270                 1275             


Ser Ser  Pro Cys Leu Lys Val  Thr Gln Lys Ser Phe  Gly Ser Gln 
    1280                 1285                 1290             


Asn Ser  Asn Thr Asp Ile Met  Phe Tyr Arg Leu Ser  Met Pro Ile 
    1295                 1300                 1305             


Glu Cys  Ala Glu Val Phe Ser  Lys Thr Val Ala Gly  Gly Leu Pro 
    1310                 1315                 1320             


Gly Ala  Gly Leu Phe Gly Pro  Lys Asn Asp Leu Glu  Asp Tyr Asp 
    1325                 1330                 1335             


Ala Asp  Ser Asp Phe Glu Val  Leu Met Lys Thr Ala  His Gly His 
    1340                 1345                 1350             


Leu Val  Pro Asp Arg Val Asp  Lys Asp Lys Glu Ala  Thr Lys Pro 
    1355                 1360                 1365             


Glu Phe  Asn Asn His Lys Asp  Tyr Ala Gln Glu Lys  Pro Ser Arg 
    1370                 1375                 1380             


Leu Lys  Gln Arg Phe Leu Leu  Arg Arg Thr Lys Pro  Asp Tyr Ser 
    1385                 1390                 1395             


Thr Ser  His Ser Ala Arg Leu  Thr Glu Asp Val Leu  Ala Asp Asp 
    1400                 1405                 1410             


Arg Asp  Asp Tyr Asp Phe Leu  Met Gln Thr Ser Thr  Tyr Tyr Tyr 
    1415                 1420                 1425             


Ser Val  Arg Ile Phe Pro Gly  Gln Glu Pro Ala Asn  Val Trp Val 
    1430                 1435                 1440             


Gly Trp  Ile Thr Ser Asp Phe  His Gln Tyr Asp Thr  Gly Phe Asp 
    1445                 1450                 1455             


Leu Asp  Arg Val Arg Thr Val  Thr Val Thr Leu Gly  Asp Glu Lys 
    1460                 1465                 1470             


Gly Lys  Val His Glu Ser Ile  Lys Arg Ser Asn Cys  Tyr Met Val 
    1475                 1480                 1485             


Cys Ala  Gly Glu Ser Met Ser  Pro Gly Gln Gly Arg  Asn Asn Asn 
    1490                 1495                 1500             


Gly Leu  Glu Ile Gly Cys Val  Val Asp Ala Ala Ser  Gly Leu Leu 
    1505                 1510                 1515             


Thr Phe  Ile Ala Asn Gly Lys  Glu Leu Ser Thr Tyr  Tyr Gln Val 
    1520                 1525                 1530             


Glu Pro  Ser Thr Lys Leu Phe  Pro Ala Val Phe Ala  Gln Ala Thr 
    1535                 1540                 1545             


Ser Pro  Asn Val Phe Gln Phe  Glu Leu Gly Arg Ile  Lys Asn Val 
    1550                 1555                 1560             


Met Pro  Leu Ser Ala Gly Leu  Phe Lys Ser Glu His  Lys Asn Pro 
    1565                 1570                 1575             


Val Pro  Gln Cys Pro Pro Arg  Leu His Val Gln Phe  Leu Ser His 
    1580                 1585                 1590             


Val Leu  Trp Ser Arg Met Pro  Asn Gln Phe Leu Lys  Val Asp Val 
    1595                 1600                 1605             


Ser Arg  Ile Ser Glu Arg Gln  Gly Trp Leu Val Gln  Cys Leu Asp 
    1610                 1615                 1620             


Pro Leu  Gln Phe Met Ser Leu  His Ile Pro Glu Glu  Asn Arg Ser 
    1625                 1630                 1635             


Val Asp  Ile Leu Glu Leu Thr  Glu Gln Glu Glu Leu  Leu Lys Phe 
    1640                 1645                 1650             


His Tyr  His Thr Leu Arg Leu  Tyr Ser Ala Val Cys  Ala Leu Gly 
    1655                 1660                 1665             


Asn His  Arg Val Ala His Ala  Leu Cys Ser His Val  Asp Glu Pro 
    1670                 1675                 1680             


Gln Leu  Leu Tyr Ala Ile Glu  Asn Lys Tyr Met Pro  Gly Leu Leu 
    1685                 1690                 1695             


Arg Ala  Gly Tyr Tyr Asp Leu  Leu Ile Asp Ile His  Leu Ser Ser 
    1700                 1705                 1710             


Tyr Ala  Thr Ala Arg Leu Met  Met Asn Asn Glu Tyr  Ile Val Pro 
    1715                 1720                 1725             


Met Thr  Glu Glu Thr Lys Ser  Ile Thr Leu Phe Pro  Asp Glu Asn 
    1730                 1735                 1740             


Lys Lys  His Gly Leu Pro Gly  Ile Gly Leu Ser Thr  Ser Leu Arg 
    1745                 1750                 1755             


Pro Arg  Met Gln Phe Ser Ser  Pro Ser Phe Val Ser  Ile Ser Asn 
    1760                 1765                 1770             


Glu Cys  Tyr Gln Tyr Ser Pro  Glu Phe Pro Leu Asp  Ile Leu Lys 
    1775                 1780                 1785             


Ser Lys  Thr Ile Gln Met Leu  Thr Glu Ala Val Lys  Glu Gly Ser 
    1790                 1795                 1800             


Leu His  Ala Arg Asp Pro Val  Gly Gly Thr Thr Glu  Phe Leu Phe 
    1805                 1810                 1815             


Val Pro  Leu Ile Lys Leu Phe  Tyr Thr Leu Leu Ile  Met Gly Ile 
    1820                 1825                 1830             


Phe His  Asn Glu Asp Leu Lys  His Ile Leu Gln Leu  Ile Glu Pro 
    1835                 1840                 1845             


Ser Val  Phe Lys Glu Ala Ala  Thr Pro Glu Glu Glu  Ser Asp Thr 
    1850                 1855                 1860             


Leu Glu  Lys Glu Leu Ser Val  Asp Asp Ala Lys Leu  Gln Gly Ala 
    1865                 1870                 1875             


Gly Glu  Glu Glu Ala Lys Gly  Gly Lys Arg Pro Lys  Glu Gly Leu 
    1880                 1885                 1890             


Leu Gln  Met Lys Leu Pro Glu  Pro Val Lys Leu Gln  Met Cys Leu 
    1895                 1900                 1905             


Leu Leu  Gln Tyr Leu Cys Asp  Cys Gln Val Arg His  Arg Ile Glu 
    1910                 1915                 1920             


Ala Ile  Val Ala Phe Ser Asp  Asp Phe Val Ala Lys  Leu Gln Asp 
    1925                 1930                 1935             


Asn Gln  Arg Phe Arg Tyr Asn  Glu Val Met Gln Ala  Leu Asn Met 
    1940                 1945                 1950             


Ser Ala  Ala Leu Thr Ala Arg  Lys Thr Lys Glu Phe  Arg Ser Pro 
    1955                 1960                 1965             


Pro Gln  Glu Gln Ile Asn Met  Leu Leu Asn Phe Lys  Asp Asp Lys 
    1970                 1975                 1980             


Ser Glu  Cys Pro Cys Pro Glu  Glu Ile Arg Asp Gln  Leu Leu Asp 
    1985                 1990                 1995             


Phe His  Glu Asp Leu Met Thr  His Cys Gly Ile Glu  Leu Asp Glu 
    2000                 2005                 2010             


Asp Gly  Ser Leu Asp Gly Asn  Ser Asp Leu Thr Ile  Arg Gly Arg 
    2015                 2020                 2025             


Leu Leu  Ser Leu Val Glu Lys  Val Thr Tyr Leu Lys  Lys Lys Gln 
    2030                 2035                 2040             


Ala Glu  Lys Pro Val Glu Ser  Asp Ser Lys Lys Ser  Ser Thr Leu 
    2045                 2050                 2055             


Gln Gln  Leu Ile Ser Glu Thr  Met Val Arg Trp Ala  Gln Glu Ser 
    2060                 2065                 2070             


Val Ile  Glu Asp Pro Glu Leu  Val Arg Ala Met Phe  Val Leu Leu 
    2075                 2080                 2085             


His Arg  Gln Tyr Asp Gly Ile  Gly Gly Leu Val Arg  Ala Leu Pro 
    2090                 2095                 2100             


Lys Thr  Tyr Thr Ile Asn Gly  Val Ser Val Glu Asp  Thr Ile Asn 
    2105                 2110                 2115             


Leu Leu  Ala Ser Leu Gly Gln  Ile Arg Ser Leu Leu  Ser Val Arg 
    2120                 2125                 2130             


Met Gly  Lys Glu Glu Glu Lys  Leu Met Ile Arg Gly  Leu Gly Asp 
    2135                 2140                 2145             


Ile Met  Asn Asn Lys Val Phe  Tyr Gln His Pro Asn  Leu Met Arg 
    2150                 2155                 2160             


Ala Leu  Gly Met His Glu Thr  Val Met Glu Val Met  Val Asn Val 
    2165                 2170                 2175             


Leu Gly  Gly Gly Glu Ser Lys  Glu Ile Thr Phe Pro  Lys Met Val 
    2180                 2185                 2190             


Ala Asn  Cys Cys Arg Phe Leu  Cys Tyr Phe Cys Arg  Ile Ser Arg 
    2195                 2200                 2205             


Gln Asn  Gln Lys Ala Met Phe  Asp His Leu Ser Tyr  Leu Leu Glu 
    2210                 2215                 2220             


Asn Ser  Ser Val Gly Leu Ala  Ser Pro Ala Met Arg  Gly Ser Thr 
    2225                 2230                 2235             


Pro Leu  Asp Val Ala Ala Ala  Ser Val Met Asp Asn  Asn Glu Leu 
    2240                 2245                 2250             


Ala Leu  Ala Leu Arg Glu Pro  Asp Leu Glu Lys Val  Val Arg Tyr 
    2255                 2260                 2265             


Leu Ala  Gly Cys Gly Leu Gln  Ser Cys Gln Met Leu  Val Ser Lys 
    2270                 2275                 2280             


Gly Tyr  Pro Asp Ile Gly Trp  Asn Pro Val Glu Gly  Glu Arg Tyr 
    2285                 2290                 2295             


Leu Asp  Phe Leu Arg Phe Ala  Val Phe Cys Asn Gly  Glu Ser Val 
    2300                 2305                 2310             


Glu Glu  Asn Ala Asn Val Val  Val Arg Leu Leu Ile  Arg Arg Pro 
    2315                 2320                 2325             


Glu Cys  Phe Gly Pro Ala Leu  Arg Gly Glu Gly Gly  Asn Gly Leu 
    2330                 2335                 2340             


Leu Ala  Ala Met Glu Glu Ala  Ile Lys Ile Ala Glu  Asp Pro Ser 
    2345                 2350                 2355             


Arg Asp  Gly Pro Ser Pro Asn  Ser Gly Ser Ser Lys  Thr Leu Asp 
    2360                 2365                 2370             


Thr Glu  Glu Glu Glu Asp Asp  Thr Ile His Met Gly  Asn Ala Ile 
    2375                 2380                 2385             


Met Thr  Phe Tyr Ser Ala Leu  Ile Asp Leu Leu Gly  Arg Cys Ala 
    2390                 2395                 2400             


Pro Glu  Met His Leu Ile His  Ala Gly Lys Gly Glu  Ala Ile Arg 
    2405                 2410                 2415             


Ile Arg  Ser Ile Leu Arg Ser  Leu Ile Pro Leu Gly  Asp Leu Val 
    2420                 2425                 2430             


Gly Val  Ile Ser Ile Ala Phe  Gln Met Pro Thr Ile  Ala Lys Asp 
    2435                 2440                 2445             


Gly Asn  Val Val Glu Pro Asp  Met Ser Ala Gly Phe  Cys Pro Asp 
    2450                 2455                 2460             


His Lys  Ala Ala Met Val Leu  Phe Leu Asp Arg Val  Tyr Gly Ile 
    2465                 2470                 2475             


Glu Val  Gln Asp Phe Leu Leu  His Leu Leu Glu Val  Gly Phe Leu 
    2480                 2485                 2490             


Pro Asp  Leu Arg Ala Ala Ala  Ser Leu Asp Thr Ala  Ala Leu Ser 
    2495                 2500                 2505             


Ala Thr  Asp Met Ala Leu Ala  Leu Asn Arg Tyr Leu  Cys Thr Ala 
    2510                 2515                 2520             


Val Leu  Pro Leu Leu Thr Arg  Cys Ala Pro Leu Phe  Ala Gly Thr 
    2525                 2530                 2535             


Glu His  His Ala Ser Leu Ile  Asp Ser Leu Leu His  Thr Val Tyr 
    2540                 2545                 2550             


Arg Leu  Ser Lys Gly Cys Ser  Leu Thr Lys Ala Gln  Arg Asp Ser 
    2555                 2560                 2565             


Ile Glu  Val Cys Leu Leu Ser  Ile Cys Gly Gln Leu  Arg Pro Ser 
    2570                 2575                 2580             


Met Met  Gln His Leu Leu Arg  Arg Leu Val Phe Asp  Val Pro Leu 
    2585                 2590                 2595             


Leu Asn  Glu His Ala Lys Met  Pro Leu Lys Leu Leu  Thr Asn His 
    2600                 2605                 2610             


Tyr Glu  Arg Cys Trp Lys Tyr  Tyr Cys Leu Pro Gly  Gly Trp Gly 
    2615                 2620                 2625             


Asn Phe  Gly Ala Ala Ser Glu  Glu Glu Leu His Leu  Ser Arg Lys 
    2630                 2635                 2640             


Leu Phe  Trp Gly Ile Phe Asp  Ala Leu Ser Gln Lys  Lys Tyr Glu 
    2645                 2650                 2655             


Gln Glu  Leu Phe Lys Leu Ala  Leu Pro Cys Leu Ser  Ala Val Ala 
    2660                 2665                 2670             


Gly Ala  Leu Pro Pro Asp Tyr  Met Glu Ser Asn Tyr  Val Ser Met 
    2675                 2680                 2685             


Met Glu  Lys Gln Ser Ser Met  Asp Ser Glu Gly Asn  Phe Asn Pro 
    2690                 2695                 2700             


Gln Pro  Val Asp Thr Ser Asn  Ile Thr Ile Pro Glu  Lys Leu Glu 
    2705                 2710                 2715             


Tyr Phe  Ile Asn Lys Tyr Ala  Glu His Ser His Asp  Lys Trp Ser 
    2720                 2725                 2730             


Met Asp  Lys Leu Ala Asn Gly  Trp Ile Tyr Gly Glu  Ile Tyr Ser 
    2735                 2740                 2745             


Asp Ser  Ser Lys Val Gln Pro  Leu Met Lys Pro Tyr  Lys Leu Leu 
    2750                 2755                 2760             


Ser Glu  Lys Glu Lys Glu Ile  Tyr Arg Trp Pro Ile  Lys Glu Ser 
    2765                 2770                 2775             


Leu Lys  Thr Met Leu Ala Trp  Gly Trp Arg Ile Glu  Arg Thr Arg 
    2780                 2785                 2790             


Glu Gly  Asp Ser Met Ala Leu  Tyr Asn Arg Thr Arg  Arg Ile Ser 
    2795                 2800                 2805             


Gln Thr  Ser Gln Val Ser Val  Asp Ala Ala His Gly  Tyr Ser Pro 
    2810                 2815                 2820             


Arg Ala  Ile Asp Met Ser Asn  Val Thr Leu Ser Arg  Asp Leu His 
    2825                 2830                 2835             


Ala Met  Ala Glu Met Met Ala  Glu Asn Tyr His Asn  Ile Trp Ala 
    2840                 2845                 2850             


Lys Lys  Lys Lys Met Glu Leu  Glu Ser Lys Gly Gly  Gly Asn His 
    2855                 2860                 2865             


Pro Leu  Leu Val Pro Tyr Asp  Thr Leu Thr Ala Lys  Glu Lys Ala 
    2870                 2875                 2880             


Lys Asp  Arg Glu Lys Ala Gln  Asp Ile Leu Lys Phe  Leu Gln Ile 
    2885                 2890                 2895             


Asn Gly  Tyr Ala Val Ser Arg  Gly Phe Lys Asp Leu  Glu Leu Asp 
    2900                 2905                 2910             


Thr Pro  Ser Ile Glu Lys Arg  Phe Ala Tyr Ser Phe  Leu Gln Gln 
    2915                 2920                 2925             


Leu Ile  Arg Tyr Val Asp Glu  Ala His Gln Tyr Ile  Leu Glu Phe 
    2930                 2935                 2940             


Asp Gly  Gly Ser Arg Gly Lys  Gly Glu His Phe Pro  Tyr Glu Gln 
    2945                 2950                 2955             


Glu Ile  Lys Phe Phe Ala Lys  Val Val Leu Pro Leu  Ile Asp Gln 
    2960                 2965                 2970             


Tyr Phe  Lys Asn His Arg Leu  Tyr Phe Leu Ser Ala  Ala Ser Arg 
    2975                 2980                 2985             


Pro Leu  Cys Ser Gly Gly His  Ala Ser Asn Lys Glu  Lys Glu Met 
    2990                 2995                 3000             


Val Thr  Ser Leu Phe Cys Lys  Leu Gly Val Leu Val  Arg His Arg 
    3005                 3010                 3015             


Ile Ser  Leu Phe Gly Asn Asp  Ala Thr Ser Ile Val  Asn Cys Leu 
    3020                 3025                 3030             


His Ile  Leu Gly Gln Thr Leu  Asp Ala Arg Thr Val  Met Lys Thr 
    3035                 3040                 3045             


Gly Leu  Glu Ser Val Lys Ser  Ala Leu Arg Ala Phe  Leu Asp Asn 
    3050                 3055                 3060             


Ala Ala  Glu Asp Leu Glu Lys  Thr Met Glu Asn Leu  Lys Gln Gly 
    3065                 3070                 3075             


Gln Phe  Thr His Thr Arg Asn  Gln Pro Lys Gly Val  Thr Gln Ile 
    3080                 3085                 3090             


Ile Asn  Tyr Thr Thr Val Ala  Leu Leu Pro Met Leu  Ser Ser Leu 
    3095                 3100                 3105             


Phe Glu  His Ile Gly Gln His  Gln Phe Gly Glu Asp  Leu Ile Leu 
    3110                 3115                 3120             


Glu Asp  Val Gln Val Ser Cys  Tyr Arg Ile Leu Thr  Ser Leu Tyr 
    3125                 3130                 3135             


Ala Leu  Gly Thr Ser Lys Ser  Ile Tyr Val Glu Arg  Gln Arg Ser 
    3140                 3145                 3150             


Ala Leu  Gly Glu Cys Leu Ala  Ala Phe Ala Gly Ala  Phe Pro Val 
    3155                 3160                 3165             


Ala Phe  Leu Glu Thr His Leu  Asp Lys His Asn Ile  Tyr Ser Ile 
    3170                 3175                 3180             


Tyr Asn  Thr Lys Ser Ser Arg  Glu Arg Ala Ala Leu  Ser Leu Pro 
    3185                 3190                 3195             


Thr Asn  Val Glu Asp Val Cys  Pro Asn Ile Pro Ser  Leu Glu Lys 
    3200                 3205                 3210             


Leu Met  Glu Glu Ile Val Glu  Leu Ala Glu Ser Gly  Ile Arg Tyr 
    3215                 3220                 3225             


Thr Gln  Met Pro His Val Met  Glu Val Ile Leu Pro  Met Leu Cys 
    3230                 3235                 3240             


Ser Tyr  Met Ser Arg Trp Trp  Glu His Gly Pro Glu  Asn Asn Pro 
    3245                 3250                 3255             


Glu Arg  Ala Glu Met Cys Cys  Thr Ala Leu Asn Ser  Glu His Met 
    3260                 3265                 3270             


Asn Thr  Leu Leu Gly Asn Ile  Leu Lys Ile Ile Tyr  Asn Asn Leu 
    3275                 3280                 3285             


Gly Ile  Asp Glu Gly Ala Trp  Met Lys Arg Leu Ala  Val Phe Ser 
    3290                 3295                 3300             


Gln Pro  Ile Ile Asn Lys Val  Lys Pro Gln Leu Leu  Lys Thr His 
    3305                 3310                 3315             


Phe Leu  Pro Leu Met Glu Lys  Leu Lys Lys Lys Ala  Ala Thr Val 
    3320                 3325                 3330             


Val Ser  Glu Glu Asp His Leu  Lys Ala Glu Ala Arg  Gly Asp Met 
    3335                 3340                 3345             


Ser Glu  Ala Glu Leu Leu Ile  Leu Asp Glu Phe Thr  Thr Leu Ala 
    3350                 3355                 3360             


Arg Asp  Leu Tyr Ala Phe Tyr  Pro Leu Leu Ile Arg  Phe Val Asp 
    3365                 3370                 3375             


Tyr Asn  Arg Ala Lys Trp Leu  Lys Glu Pro Asn Pro  Glu Ala Glu 
    3380                 3385                 3390             


Glu Leu  Phe Arg Met Val Ala  Glu Val Phe Ile Tyr  Trp Ser Lys 
    3395                 3400                 3405             


Ser His  Asn Phe Lys Arg Glu  Glu Gln Asn Phe Val  Val Gln Asn 
    3410                 3415                 3420             


Glu Ile  Asn Asn Met Ser Phe  Leu Ile Thr Asp Thr  Lys Ser Lys 
    3425                 3430                 3435             


Met Ser  Lys Ala Ala Val Ser  Asp Gln Glu Arg Lys  Lys Met Lys 
    3440                 3445                 3450             


Arg Lys  Gly Asp Arg Tyr Ser  Met Gln Thr Ser Leu  Ile Val Ala 
    3455                 3460                 3465             


Ala Leu  Lys Arg Leu Leu Pro  Ile Gly Leu Asn Ile  Cys Ala Pro 
    3470                 3475                 3480             


Gly Asp  Gln Glu Leu Ile Ala  Leu Ala Lys Asn Arg  Phe Ser Leu 
    3485                 3490                 3495             


Lys Asp  Thr Glu Asp Glu Val  Arg Asp Ile Ile Arg  Ser Asn Ile 
    3500                 3505                 3510             


His Leu  Gln Gly Lys Leu Glu  Asp Pro Ala Ile Arg  Trp Gln Met 
    3515                 3520                 3525             


Ala Leu  Tyr Lys Asp Leu Pro  Asn Arg Thr Asp Asp  Thr Ser Asp 
    3530                 3535                 3540             


Pro Glu  Lys Thr Val Glu Arg  Val Leu Asp Ile Ala  Asn Val Leu 
    3545                 3550                 3555             


Phe His  Leu Glu Gln Lys Ser  Lys Arg Val Gly Arg  Arg His Tyr 
    3560                 3565                 3570             


Cys Leu  Val Glu His Pro Gln  Arg Ser Lys Lys Ala  Val Trp His 
    3575                 3580                 3585             


Lys Leu  Leu Ser Lys Gln Arg  Lys Arg Ala Val Val  Ala Cys Phe 
    3590                 3595                 3600             


Arg Met  Ala Pro Leu Tyr Asn  Leu Pro Arg His Arg  Ala Val Asn 
    3605                 3610                 3615             


Leu Phe  Leu Gln Gly Tyr Glu  Lys Ser Trp Ile Glu  Thr Glu Glu 
    3620                 3625                 3630             


His Tyr  Phe Glu Asp Lys Leu  Ile Glu Asp Leu Ala  Lys Pro Gly 
    3635                 3640                 3645             


Ala Glu  Pro Pro Glu Glu Asp  Glu Gly Thr Lys Arg  Val Asp Pro 
    3650                 3655                 3660             


Leu His  Gln Leu Ile Leu Leu  Phe Ser Arg Thr Ala  Leu Thr Glu 
    3665                 3670                 3675             


Lys Cys  Lys Leu Glu Glu Asp  Phe Leu Tyr Met Ala  Tyr Ala Asp 
    3680                 3685                 3690             


Ile Met  Ala Lys Ser Cys His  Asp Glu Glu Asp Asp  Asp Gly Glu 
    3695                 3700                 3705             


Glu Glu  Val Lys Ser Phe Glu  Glu Lys Glu Met Glu  Lys Gln Lys 
    3710                 3715                 3720             


Leu Leu  Tyr Gln Gln Ala Arg  Leu His Asp Arg Gly  Ala Ala Glu 
    3725                 3730                 3735             


Met Val  Leu Gln Thr Ile Ser  Ala Ser Lys Gly Glu  Thr Gly Pro 
    3740                 3745                 3750             


Met Val  Ala Ala Thr Leu Lys  Leu Gly Ile Ala Ile  Leu Asn Gly 
    3755                 3760                 3765             


Gly Asn  Ser Thr Val Gln Gln  Lys Met Leu Asp Tyr  Leu Lys Glu 
    3770                 3775                 3780             


Lys Lys  Asp Val Gly Phe Phe  Gln Ser Leu Ala Gly  Leu Met Gln 
    3785                 3790                 3795             


Ser Cys  Ser Val Leu Asp Leu  Asn Ala Phe Glu Arg  Gln Asn Lys 
    3800                 3805                 3810             


Ala Glu  Gly Leu Gly Met Val  Thr Glu Glu Gly Ser  Gly Glu Lys 
    3815                 3820                 3825             


Val Leu  Gln Asp Asp Glu Phe  Thr Cys Asp Leu Phe  Arg Phe Leu 
    3830                 3835                 3840             


Gln Leu  Leu Cys Glu Gly His  Asn Ser Asp Phe Gln  Asn Tyr Leu 
    3845                 3850                 3855             


Arg Thr  Gln Thr Gly Asn Asn  Thr Thr Val Asn Ile  Ile Ile Ser 
    3860                 3865                 3870             


Thr Val  Asp Tyr Leu Leu Arg  Val Gln Glu Ser Ile  Ser Asp Phe 
    3875                 3880                 3885             


Tyr Trp  Tyr Tyr Ser Gly Lys  Asp Val Ile Asp Glu  Gln Gly Gln 
    3890                 3895                 3900             


Arg Asn  Phe Ser Lys Ala Ile  Gln Val Ala Lys Gln  Val Phe Asn 
    3905                 3910                 3915             


Thr Leu  Thr Glu Tyr Ile Gln  Gly Pro Cys Thr Gly  Asn Gln Gln 
    3920                 3925                 3930             


Ser Leu  Ala His Ser Arg Leu  Trp Asp Ala Val Val  Gly Phe Leu 
    3935                 3940                 3945             


His Val  Phe Ala His Met Gln  Met Lys Leu Ser Gln  Asp Ser Ser 
    3950                 3955                 3960             


Gln Ile  Glu Leu Leu Lys Glu  Leu Met Asp Leu Gln  Lys Asp Met 
    3965                 3970                 3975             


Val Val  Met Leu Leu Ser Met  Leu Glu Gly Asn Val  Val Asn Gly 
    3980                 3985                 3990             


Thr Ile  Gly Lys Gln Met Val  Asp Met Leu Val Glu  Ser Ser Asn 
    3995                 4000                 4005             


Asn Val  Glu Met Ile Leu Lys  Phe Phe Asp Met Phe  Leu Lys Leu 
    4010                 4015                 4020             


Lys Asp  Leu Thr Ser Ser Asp  Thr Phe Lys Glu Tyr  Asp Pro Asp 
    4025                 4030                 4035             


Gly Lys  Gly Val Ile Ser Lys  Arg Asp Phe His Lys  Ala Met Glu 
    4040                 4045                 4050             


Ser His  Lys His Tyr Thr Gln  Ser Glu Thr Glu Phe  Leu Leu Ser 
    4055                 4060                 4065             


Cys Ala  Glu Thr Asp Glu Asn  Glu Thr Leu Asp Tyr  Glu Glu Phe 
    4070                 4075                 4080             


Val Lys  Arg Phe His Glu Pro  Ala Lys Asp Ile Gly  Phe Asn Val 
    4085                 4090                 4095             


Ala Val  Leu Leu Thr Asn Leu  Ser Glu His Met Pro  Asn Asp Thr 
    4100                 4105                 4110             


Arg Leu  Gln Thr Phe Leu Glu  Leu Ala Glu Ser Val  Leu Asn Tyr 
    4115                 4120                 4125             


Phe Gln  Pro Phe Leu Gly Arg  Ile Glu Ile Met Gly  Ser Ala Lys 
    4130                 4135                 4140             


Arg Ile  Glu Arg Val Tyr Phe  Glu Ile Ser Glu Ser  Ser Arg Thr 
    4145                 4150                 4155             


Gln Trp  Glu Lys Pro Gln Val  Lys Glu Ser Lys Arg  Gln Phe Ile 
    4160                 4165                 4170             


Phe Asp  Val Val Asn Glu Gly  Gly Glu Lys Glu Lys  Met Glu Leu 
    4175                 4180                 4185             


Phe Val  Asn Phe Cys Glu Asp  Thr Ile Phe Glu Met  Gln Leu Ala 
    4190                 4195                 4200             


Ala Gln  Ile Ser Glu Ser Asp  Leu Asn Glu Arg Ser  Ala Asn Lys 
    4205                 4210                 4215             


Glu Glu  Ser Glu Lys Glu Arg  Pro Glu Glu Gln Gly  Pro Arg Met 
    4220                 4225                 4230             


Ala Phe  Phe Ser Ile Leu Thr  Val Arg Ser Ala Leu  Phe Ala Leu 
    4235                 4240                 4245             


Arg Tyr  Asn Ile Leu Thr Leu  Met Arg Met Leu Ser  Leu Lys Ser 
    4250                 4255                 4260             


Leu Lys  Lys Gln Met Lys Lys  Val Lys Lys Met Thr  Val Lys Asp 
    4265                 4270                 4275             


Met Val  Thr Ala Phe Phe Ser  Ser Tyr Trp Ser Ile  Phe Met Thr 
    4280                 4285                 4290             


Leu Leu  His Phe Val Ala Ser  Val Phe Arg Gly Phe  Phe Arg Ile 
    4295                 4300                 4305             


Ile Cys  Ser Leu Leu Leu Gly  Gly Ser Leu Val Glu  Gly Ala Lys 
    4310                 4315                 4320             


Lys Ile  Lys Val Ala Glu Leu  Leu Ala Asn Met Pro  Asp Pro Thr 
    4325                 4330                 4335             


Gln Asp  Glu Val Arg Gly Asp  Gly Glu Glu Gly Glu  Arg Lys Pro 
    4340                 4345                 4350             


Leu Glu  Ala Ala Leu Pro Ser  Glu Asp Leu Thr Asp  Leu Lys Glu 
    4355                 4360                 4365             


Leu Thr  Glu Glu Ser Asp Leu  Leu Ser Asp Ile Phe  Gly Leu Asp 
    4370                 4375                 4380             


Leu Lys  Arg Glu Gly Gly Gln  Tyr Lys Leu Ile Pro  His Asn Pro 
    4385                 4390                 4395             


Asn Ala  Gly Leu Ser Asp Leu  Met Ser Asn Pro Val  Pro Met Pro 
    4400                 4405                 4410             


Glu Val  Gln Glu Lys Phe Gln  Glu Gln Lys Ala Lys  Glu Glu Glu 
    4415                 4420                 4425             


Lys Glu  Glu Lys Glu Glu Thr  Lys Ser Glu Pro Glu  Lys Ala Glu 
    4430                 4435                 4440             


Gly Glu  Asp Gly Glu Lys Glu  Glu Lys Ala Lys Glu  Asp Lys Gly 
    4445                 4450                 4455             


Lys Gln  Lys Leu Arg Gln Leu  His Thr His Arg Tyr  Gly Glu Pro 
    4460                 4465                 4470             


Glu Val  Pro Glu Ser Ala Phe  Trp Lys Lys Ile Ile  Ala Tyr Gln 
    4475                 4480                 4485             


Gln Lys  Leu Leu Asn Tyr Phe  Ala Arg Asn Phe Tyr  Asn Met Arg 
    4490                 4495                 4500             


Met Leu  Ala Leu Phe Val Ala  Phe Ala Ile Asn Phe  Ile Leu Leu 
    4505                 4510                 4515             


Phe Tyr  Lys Val Ser Thr Ser  Ser Val Val Glu Gly  Lys Glu Leu 
    4520                 4525                 4530             


Pro Thr  Arg Ser Ser Ser Glu  Asn Ala Lys Val Thr  Ser Leu Asp 
    4535                 4540                 4545             


Ser Ser  Ser His Arg Ile Ile  Ala Val His Tyr Val  Leu Glu Glu 
    4550                 4555                 4560             


Ser Ser  Gly Tyr Met Glu Pro  Thr Leu Arg Ile Leu  Ala Ile Leu 
    4565                 4570                 4575             


His Thr  Val Ile Ser Phe Phe  Cys Ile Ile Gly Tyr  Tyr Cys Leu 
    4580                 4585                 4590             


Lys Val  Pro Leu Val Ile Phe  Lys Arg Glu Lys Glu  Val Ala Arg 
    4595                 4600                 4605             


Lys Leu  Glu Phe Asp Gly Leu  Tyr Ile Thr Glu Gln  Pro Ser Glu 
    4610                 4615                 4620             


Asp Asp  Ile Lys Gly Gln Trp  Asp Arg Leu Val Ile  Asn Thr Gln 
    4625                 4630                 4635             


Ser Phe  Pro Asn Asn Tyr Trp  Asp Lys Phe Val Lys  Arg Lys Val 
    4640                 4645                 4650             


Met Asp  Lys Tyr Gly Glu Phe  Tyr Gly Arg Asp Arg  Ile Ser Glu 
    4655                 4660                 4665             


Leu Leu  Gly Met Asp Lys Ala  Ala Leu Asp Phe Ser  Asp Ala Arg 
    4670                 4675                 4680             


Glu Lys  Lys Lys Pro Lys Lys  Asp Ser Ser Leu Ser  Ala Val Leu 
    4685                 4690                 4695             


Asn Ser  Ile Asp Val Lys Tyr  Gln Met Trp Lys Leu  Gly Val Val 
    4700                 4705                 4710             


Phe Thr  Asp Asn Ser Phe Leu  Tyr Leu Ala Trp Tyr  Met Thr Met 
    4715                 4720                 4725             


Ser Val  Leu Gly His Tyr Asn  Asn Phe Phe Phe Ala  Ala His Leu 
    4730                 4735                 4740             


Leu Asp  Ile Ala Met Gly Phe  Lys Thr Leu Arg Thr  Ile Leu Ser 
    4745                 4750                 4755             


Ser Val  Thr His Asn Gly Lys  Gln Leu Val Leu Thr  Val Gly Leu 
    4760                 4765                 4770             


Leu Ala  Val Val Val Tyr Leu  Tyr Thr Val Val Ala  Phe Asn Phe 
    4775                 4780                 4785             


Phe Arg  Lys Phe Tyr Asn Lys  Ser Glu Asp Gly Asp  Thr Pro Asp 
    4790                 4795                 4800             


Met Lys  Cys Asp Asp Met Leu  Thr Cys Tyr Met Phe  His Met Tyr 
    4805                 4810                 4815             


Val Gly  Val Arg Ala Gly Gly  Gly Ile Gly Asp Glu  Ile Glu Asp 
    4820                 4825                 4830             


Pro Ala  Gly Asp Glu Tyr Glu  Ile Tyr Arg Ile Ile  Phe Asp Ile 
    4835                 4840                 4845             


Thr Phe  Phe Phe Phe Val Ile  Val Ile Leu Leu Ala  Ile Ile Gln 
    4850                 4855                 4860             


Gly Leu  Ile Ile Asp Ala Phe  Gly Glu Leu Arg Asp  Gln Gln Glu 
    4865                 4870                 4875             


Gln Val  Lys Glu Asp Met Glu  Thr Lys Cys Phe Ile  Cys Gly Ile 
    4880                 4885                 4890             


Gly Asn  Asp Tyr Phe Asp Thr  Val Pro His Gly Phe  Glu Thr His 
    4895                 4900                 4905             


Thr Leu  Gln Glu His Asn Leu  Ala Asn Tyr Leu Phe  Phe Leu Met 
    4910                 4915                 4920             


Tyr Leu  Ile Asn Lys Asp Glu  Thr Glu His Thr Gly  Gln Glu Ser 
    4925                 4930                 4935             


Tyr Val  Trp Lys Met Tyr Gln  Glu Arg Cys Trp Glu  Phe Phe Pro 
    4940                 4945                 4950             


Ala Gly  Asp Cys Phe Arg Lys  Gln Tyr Glu Asp Gln  Leu Asn 
    4955                 4960                 4965         

<210>  88
<211>  1602
<212>  DNA
<213>  Homo sapiens

<400>  88
accgtcaggg gccgacccgc cgcgccccag cgttctccgc gtacaggtgg tctcttgggt     60

tccggtaagg cggcggctgc ggaactcccg tggaggggcc ggtgggccct cgggcctgac    120

gatggcagtg gccactgcgg cggcagtact ggccgctctg ggcggggcgc tgtggctggc    180

ggcccgccgg ttcgtggggc ccagggtcca gcggctgcgc agaggcgggg accccggcct    240

catgcacggg aagactgtgc tgatcaccgg ggcgaacagc ggcctgggcc gcgccacggc    300

cgccgagcta ctgcgcctgg gagcgcgggt gatcatgggc tgccgggacc gcgcgcgcgc    360

cgaggaggcg gcgggtcagc tccgccgcga gctccgccag gccgcggagt gcggcccaga    420

gcctggcgtc agcggggtgg gcgagctcat agtccgggag ctggacctcg cctcgctgcg    480

ctcggtgcgc gccttctgcc aggaaatgct ccaggaagag cctaggctgg atgtcttgat    540

caataacgca gggatcttcc agtgccctta catgaagact gaagatgggt ttgagatgca    600

gttcggagtg aaccatctgg ggcactttct actcaccaat cttctccttg gactcctcaa    660

aagttcagct cccagcagga ttgtggtagt ttcttccaaa ctttataaat acggagacat    720

caattttgat gacttgaaca gtgaacaaag ctataataaa agcttttgtt atagccggag    780

caaactggct aacattcttt ttaccaggga actagcccgc cgcttagaag gcacaaatgt    840

caccgtcaat gtgttgcatc ctggtattgt acggacaaat ctggggaggc acatacacat    900

tccactgttg gtcaaaccac tcttcaattt ggtgtcatgg gcttttttca aaactccagt    960

agaaggtgcc cagacttcca tttatttggc ctcttcacct gaggtagaag gagtgtcagg   1020

aagatacttt ggggattgta aagaggaaga actgttgccc aaagctatgg atgaatctgt   1080

tgcaagaaaa ctctgggata tcagtgaagt gatggttggc ctgctaaaat aggaacaagg   1140

agtaaaagag ctgtttataa aactgcatat cagttatatc tgtgatcagg aatggtgtgg   1200

attgagaact tgttacttga agaaaaagaa ttttgatatt ggaatagcct gctaagaggt   1260

acatgtgggt attttggagt tactgaaaaa ttatttttgg gataagagaa tttcagcaaa   1320

gatgttttaa atatatatag taagtataat gaataataag tacaatgaaa aatacaatta   1380

tattgtaaaa ttataactgg gcaagcatgg atgacatatt aatatttgtc agaattaagt   1440

gactcaaagt gctatcgaga ggtttttcaa gtatctttga gtttcatggc caaagtgtta   1500

actagtttta ctacaatgtt tggtgtttgt gtggaaatta tctgcctggt gtgtgcacac   1560

aagtcttact tggaataaat ttactggtac aaattcttaa aa                      1602


<210>  89
<211>  336
<212>  PRT
<213>  Homo sapiens

<400>  89


Met Ala Val Ala Thr Ala Ala Ala Val Leu Ala Ala Leu Gly Gly Ala 
1               5                   10                  15      


Leu Trp Leu Ala Ala Arg Arg Phe Val Gly Pro Arg Val Gln Arg Leu 
            20                  25                  30          


Arg Arg Gly Gly Asp Pro Gly Leu Met His Gly Lys Thr Val Leu Ile 
        35                  40                  45              


Thr Gly Ala Asn Ser Gly Leu Gly Arg Ala Thr Ala Ala Glu Leu Leu 
    50                  55                  60                  


Arg Leu Gly Ala Arg Val Ile Met Gly Cys Arg Asp Arg Ala Arg Ala 
65                  70                  75                  80  


Glu Glu Ala Ala Gly Gln Leu Arg Arg Glu Leu Arg Gln Ala Ala Glu 
                85                  90                  95      


Cys Gly Pro Glu Pro Gly Val Ser Gly Val Gly Glu Leu Ile Val Arg 
            100                 105                 110         


Glu Leu Asp Leu Ala Ser Leu Arg Ser Val Arg Ala Phe Cys Gln Glu 
        115                 120                 125             


Met Leu Gln Glu Glu Pro Arg Leu Asp Val Leu Ile Asn Asn Ala Gly 
    130                 135                 140                 


Ile Phe Gln Cys Pro Tyr Met Lys Thr Glu Asp Gly Phe Glu Met Gln 
145                 150                 155                 160 


Phe Gly Val Asn His Leu Gly His Phe Leu Leu Thr Asn Leu Leu Leu 
                165                 170                 175     


Gly Leu Leu Lys Ser Ser Ala Pro Ser Arg Ile Val Val Val Ser Ser 
            180                 185                 190         


Lys Leu Tyr Lys Tyr Gly Asp Ile Asn Phe Asp Asp Leu Asn Ser Glu 
        195                 200                 205             


Gln Ser Tyr Asn Lys Ser Phe Cys Tyr Ser Arg Ser Lys Leu Ala Asn 
    210                 215                 220                 


Ile Leu Phe Thr Arg Glu Leu Ala Arg Arg Leu Glu Gly Thr Asn Val 
225                 230                 235                 240 


Thr Val Asn Val Leu His Pro Gly Ile Val Arg Thr Asn Leu Gly Arg 
                245                 250                 255     


His Ile His Ile Pro Leu Leu Val Lys Pro Leu Phe Asn Leu Val Ser 
            260                 265                 270         


Trp Ala Phe Phe Lys Thr Pro Val Glu Gly Ala Gln Thr Ser Ile Tyr 
        275                 280                 285             


Leu Ala Ser Ser Pro Glu Val Glu Gly Val Ser Gly Arg Tyr Phe Gly 
    290                 295                 300                 


Asp Cys Lys Glu Glu Glu Leu Leu Pro Lys Ala Met Asp Glu Ser Val 
305                 310                 315                 320 


Ala Arg Lys Leu Trp Asp Ile Ser Glu Val Met Val Gly Leu Leu Lys 
                325                 330                 335     

<210>  90
<211>  2864
<212>  DNA
<213>  Homo sapiens

<400>  90
gacattctaa atgcaaagct agactgagca agggaagtga caggaaatgg agctggggag     60

acaaaaatgt ggataacaac aaaagaattt caacaggtaa aaaaatgagt caaacatctc    120

tcaaacagaa aaagaatgag cctggaatga ggtcctcaaa agagagtcta gaagcagaaa    180

aaagaaagga atctgacaaa acaggagttc gtctgagcaa tcagatgagg cgtgcagtca    240

atccgaatca ctcgctgaga tgttgcccct tccagggtca ctcgtcgtgt agacgctgcc    300

tttgtgcagc tgagggaaca gcccttggcc cctgccacac aatacgtatt tatattcaca    360

tgtgcctgtt gtgggagcag ggccagcaga tcaccatgat gaggggatca caagaatcat    420

cactgcggaa gacagactct cgagggtacc ttgtgcgcag tcaatggtct agaatatccc    480

ggagcccatc caccaaggct ccatccatag atgagcctag aagcaggaac accagtgcta    540

agctccccag cagctccacg agctcccgga ctccatccac ctccccaagc ctgcatgact    600

cctcaccgcc gccgctgtcc gggcagccct cgctccagcc acccgcgtcg ccccagctgc    660

cccggtcgct ggactcgcgg cctcccacgc ccccagagcc cgatcctggc tcccggcgca    720

gcaccaaaat gcaagagaat ccggaggcct gggcccaagg catcgtgcgg gaaatccgcc    780

agacccggga ctcgcagccg ctggaatatt cgcgcacgtc ccccaccgag tggaagtcct    840

ccagccagcg cagggggatc taccccgcct ccacccagct ggaccgcaac tctctgtccg    900

agcagcagca gcagcagcgg gaggacgagg acgactacga ggctgcctac tgggcatcca    960

tgaggtcgtt ctacgagaag aacccgagct gctcgcgccc ctggccgccc aaacccaaga   1020

acgccatcac cattgctctc tcatcctgcg cgctcttcaa catggtggac ggcaggaaaa   1080

tctacgagca agagggtctg gaaaagtaca tggagtatca gctcaccaat gagaacgtca   1140

tcctgacccc gggcccggcg ttccgcttcg tcaaggcact acagtatgtc aatgctagac   1200

tccgtgatct atatcctgat gaacaggact tatttgatat tgtactgatg actaataacc   1260

atgcccaagt gggagtgcgg cttataaaca gcgtcaatca ctacggctta ctgattgacc   1320

gcttctgtct gaccggggga aaagacccca ttggctattt gaaggcatat cttaccaact   1380

tgtatattgc tgcagattct gaaaaagtgc aagaggcaat acaagaaggt attgcctctg   1440

cgacaatgtt tgatggagcc aaagacatgg cttactgtga cactcagctc cgtgtagcct   1500

ttgatgggga tgctgtcctc ttctctgatg agtctgaaca ttttaccaag gagcatgggc   1560

tcgacaaatt cttccagtat gatacattat gtgaaagtaa gcctcttgct cagggtcccc   1620

taaaaggctt tctggaagat ttaggcagac tgcaaaagaa gttctatgcc aaaaatgaac   1680

ggttactttg tcctatcagg acctacctgg ttacagctag gagtgcagcc agttcaggcg   1740

cccgtgtgct gaagaccctt cgacgctggg gtctagagat agacgaagct cttttccttg   1800

ctggagcccc caaaagtccc atcttggtga agatccggcc ccacatcttc tttgatgacc   1860

acatgttcca cattgaaggg gcacagaggt taggttccat cgcagcttat ggctttaata   1920

aaaaattcag tagttagggg cagggaggag aaataaagtg gtgatagtct ggtgttacag   1980

aagccacttc ttttggctct ctaggataat tagataggta tttcagaaaa ttggacctta   2040

aaactttgct tctttggaaa ggttttctcc tgattttttg gaaaaccttt tgaaccctca   2100

agttaccatc aaactacttc tctttgaact accaatactg ttgaatgcca ttacacctat   2160

ctctgtgtaa gtcataatga tgactcttta ggataagttt agaacttgaa tatttgcatg   2220

cttaaggcac tgttttagaa gcttacttag ttttataaac actgctcatt tttggatgtt   2280

tgtagataac aatgaattgt tacccatcag cattgtagaa tagtgtcttc aaaggtagaa   2340

ggagtatggt taagcacact cttgaaaact ggagctttgt attctgtgac tgctatggct   2400

agctttgtaa ccaaagcaaa atgagaattt cactctacct gcatgagtat aacaattttg   2460

atactgctca tttagaaata aatcatctgg ttgttcctcc agggtacttt ctaagataag   2520

ccttaaacag aaacccctaa gaaaggttct ctgaaaatta tttggtgggt taaatgcctc   2580

tgatccacag agtttcatat ttgaagtctc cggctttggg cctggcaggc tggcacatcc   2640

atatttgtat ggaaaaaaaa aaaaaagacc ctacgctacc acttcaaaaa gtgacatgaa   2700

gtgtagtatc ctggcccttc attgtcattc tctcatgatt tttgttttgt tttcaacaaa   2760

aattggttgg tcattaaata tatcatatgt taggcacagt gacctggtta ttttcacatg   2820

ttacttcatt ttcttatcaa attaaatgtt tgtgacatag taaa                    2864


<210>  91
<211>  610
<212>  PRT
<213>  Homo sapiens

<400>  91


Met Ser Gln Thr Ser Leu Lys Gln Lys Lys Asn Glu Pro Gly Met Arg 
1               5                   10                  15      


Ser Ser Lys Glu Ser Leu Glu Ala Glu Lys Arg Lys Glu Ser Asp Lys 
            20                  25                  30          


Thr Gly Val Arg Leu Ser Asn Gln Met Arg Arg Ala Val Asn Pro Asn 
        35                  40                  45              


His Ser Leu Arg Cys Cys Pro Phe Gln Gly His Ser Ser Cys Arg Arg 
    50                  55                  60                  


Cys Leu Cys Ala Ala Glu Gly Thr Ala Leu Gly Pro Cys His Thr Ile 
65                  70                  75                  80  


Arg Ile Tyr Ile His Met Cys Leu Leu Trp Glu Gln Gly Gln Gln Ile 
                85                  90                  95      


Thr Met Met Arg Gly Ser Gln Glu Ser Ser Leu Arg Lys Thr Asp Ser 
            100                 105                 110         


Arg Gly Tyr Leu Val Arg Ser Gln Trp Ser Arg Ile Ser Arg Ser Pro 
        115                 120                 125             


Ser Thr Lys Ala Pro Ser Ile Asp Glu Pro Arg Ser Arg Asn Thr Ser 
    130                 135                 140                 


Ala Lys Leu Pro Ser Ser Ser Thr Ser Ser Arg Thr Pro Ser Thr Ser 
145                 150                 155                 160 


Pro Ser Leu His Asp Ser Ser Pro Pro Pro Leu Ser Gly Gln Pro Ser 
                165                 170                 175     


Leu Gln Pro Pro Ala Ser Pro Gln Leu Pro Arg Ser Leu Asp Ser Arg 
            180                 185                 190         


Pro Pro Thr Pro Pro Glu Pro Asp Pro Gly Ser Arg Arg Ser Thr Lys 
        195                 200                 205             


Met Gln Glu Asn Pro Glu Ala Trp Ala Gln Gly Ile Val Arg Glu Ile 
    210                 215                 220                 


Arg Gln Thr Arg Asp Ser Gln Pro Leu Glu Tyr Ser Arg Thr Ser Pro 
225                 230                 235                 240 


Thr Glu Trp Lys Ser Ser Ser Gln Arg Arg Gly Ile Tyr Pro Ala Ser 
                245                 250                 255     


Thr Gln Leu Asp Arg Asn Ser Leu Ser Glu Gln Gln Gln Gln Gln Arg 
            260                 265                 270         


Glu Asp Glu Asp Asp Tyr Glu Ala Ala Tyr Trp Ala Ser Met Arg Ser 
        275                 280                 285             


Phe Tyr Glu Lys Asn Pro Ser Cys Ser Arg Pro Trp Pro Pro Lys Pro 
    290                 295                 300                 


Lys Asn Ala Ile Thr Ile Ala Leu Ser Ser Cys Ala Leu Phe Asn Met 
305                 310                 315                 320 


Val Asp Gly Arg Lys Ile Tyr Glu Gln Glu Gly Leu Glu Lys Tyr Met 
                325                 330                 335     


Glu Tyr Gln Leu Thr Asn Glu Asn Val Ile Leu Thr Pro Gly Pro Ala 
            340                 345                 350         


Phe Arg Phe Val Lys Ala Leu Gln Tyr Val Asn Ala Arg Leu Arg Asp 
        355                 360                 365             


Leu Tyr Pro Asp Glu Gln Asp Leu Phe Asp Ile Val Leu Met Thr Asn 
    370                 375                 380                 


Asn His Ala Gln Val Gly Val Arg Leu Ile Asn Ser Val Asn His Tyr 
385                 390                 395                 400 


Gly Leu Leu Ile Asp Arg Phe Cys Leu Thr Gly Gly Lys Asp Pro Ile 
                405                 410                 415     


Gly Tyr Leu Lys Ala Tyr Leu Thr Asn Leu Tyr Ile Ala Ala Asp Ser 
            420                 425                 430         


Glu Lys Val Gln Glu Ala Ile Gln Glu Gly Ile Ala Ser Ala Thr Met 
        435                 440                 445             


Phe Asp Gly Ala Lys Asp Met Ala Tyr Cys Asp Thr Gln Leu Arg Val 
    450                 455                 460                 


Ala Phe Asp Gly Asp Ala Val Leu Phe Ser Asp Glu Ser Glu His Phe 
465                 470                 475                 480 


Thr Lys Glu His Gly Leu Asp Lys Phe Phe Gln Tyr Asp Thr Leu Cys 
                485                 490                 495     


Glu Ser Lys Pro Leu Ala Gln Gly Pro Leu Lys Gly Phe Leu Glu Asp 
            500                 505                 510         


Leu Gly Arg Leu Gln Lys Lys Phe Tyr Ala Lys Asn Glu Arg Leu Leu 
        515                 520                 525             


Cys Pro Ile Arg Thr Tyr Leu Val Thr Ala Arg Ser Ala Ala Ser Ser 
    530                 535                 540                 


Gly Ala Arg Val Leu Lys Thr Leu Arg Arg Trp Gly Leu Glu Ile Asp 
545                 550                 555                 560 


Glu Ala Leu Phe Leu Ala Gly Ala Pro Lys Ser Pro Ile Leu Val Lys 
                565                 570                 575     


Ile Arg Pro His Ile Phe Phe Asp Asp His Met Phe His Ile Glu Gly 
            580                 585                 590         


Ala Gln Arg Leu Gly Ser Ile Ala Ala Tyr Gly Phe Asn Lys Lys Phe 
        595                 600                 605             


Ser Ser 
    610 

<210>  92
<211>  2684
<212>  DNA
<213>  Homo sapiens

<400>  92
gacattctaa atgcaaagct agactgagca agggaagtga caggaaatgg agctggggag     60

acaaaaatgt ggataacaac aaaagaattt caacaggtaa aaaaatgagt caaacatctc    120

tcaaacagaa aaagaatgag cctggaatga ggtcctcaaa agagagtcta gaagcagaaa    180

aaagaaagga atctgacaaa acaggagttc gtctgagcaa tcagggatca caagaatcat    240

cactgcggaa gacagactct cgagggtacc ttgtgcgcag tcaatggtct agaatatccc    300

ggagcccatc caccaaggct ccatccatag atgagcctag aagcaggaac accagtgcta    360

agctccccag cagctccacg agctcccgga ctccatccac ctccccaagc ctgcatgact    420

cctcaccgcc gccgctgtcc gggcagccct cgctccagcc acccgcgtcg ccccagctgc    480

cccggtcgct ggactcgcgg cctcccacgc ccccagagcc cgatcctggc tcccggcgca    540

gcaccaaaat gcaagagaat ccggaggcct gggcccaagg catcgtgcgg gaaatccgcc    600

agacccggga ctcgcagccg ctggaatatt cgcgcacgtc ccccaccgag tggaagtcct    660

ccagccagcg cagggggatc taccccgcct ccacccagct ggaccgcaac tctctgtccg    720

agcagcagca gcagcagcgg gaggacgagg acgactacga ggctgcctac tgggcatcca    780

tgaggtcgtt ctacgagaag aacccgagct gctcgcgccc ctggccgccc aaacccaaga    840

acgccatcac cattgctctc tcatcctgcg cgctcttcaa catggtggac ggcaggaaaa    900

tctacgagca agagggtctg gaaaagtaca tggagtatca gctcaccaat gagaacgtca    960

tcctgacccc gggcccggcg ttccgcttcg tcaaggcact acagtatgtc aatgctagac   1020

tccgtgatct atatcctgat gaacaggact tatttgatat tgtactgatg actaataacc   1080

atgcccaagt gggagtgcgg cttataaaca gcgtcaatca ctacggctta ctgattgacc   1140

gcttctgtct gaccggggga aaagacccca ttggctattt gaaggcatat cttaccaact   1200

tgtatattgc tgcagattct gaaaaagtgc aagaggcaat acaagaaggt attgcctctg   1260

cgacaatgtt tgatggagcc aaagacatgg cttactgtga cactcagctc cgtgtagcct   1320

ttgatgggga tgctgtcctc ttctctgatg agtctgaaca ttttaccaag gagcatgggc   1380

tcgacaaatt cttccagtat gatacattat gtgaaagtaa gcctcttgct cagggtcccc   1440

taaaaggctt tctggaagat ttaggcagac tgcaaaagaa gttctatgcc aaaaatgaac   1500

ggttactttg tcctatcagg acctacctgg ttacagctag gagtgcagcc agttcaggcg   1560

cccgtgtgct gaagaccctt cgacgctggg gtctagagat agacgaagct cttttccttg   1620

ctggagcccc caaaagtccc atcttggtga agatccggcc ccacatcttc tttgatgacc   1680

acatgttcca cattgaaggg gcacagaggt taggttccat cgcagcttat ggctttaata   1740

aaaaattcag tagttagggg cagggaggag aaataaagtg gtgatagtct ggtgttacag   1800

aagccacttc ttttggctct ctaggataat tagataggta tttcagaaaa ttggacctta   1860

aaactttgct tctttggaaa ggttttctcc tgattttttg gaaaaccttt tgaaccctca   1920

agttaccatc aaactacttc tctttgaact accaatactg ttgaatgcca ttacacctat   1980

ctctgtgtaa gtcataatga tgactcttta ggataagttt agaacttgaa tatttgcatg   2040

cttaaggcac tgttttagaa gcttacttag ttttataaac actgctcatt tttggatgtt   2100

tgtagataac aatgaattgt tacccatcag cattgtagaa tagtgtcttc aaaggtagaa   2160

ggagtatggt taagcacact cttgaaaact ggagctttgt attctgtgac tgctatggct   2220

agctttgtaa ccaaagcaaa atgagaattt cactctacct gcatgagtat aacaattttg   2280

atactgctca tttagaaata aatcatctgg ttgttcctcc agggtacttt ctaagataag   2340

ccttaaacag aaacccctaa gaaaggttct ctgaaaatta tttggtgggt taaatgcctc   2400

tgatccacag agtttcatat ttgaagtctc cggctttggg cctggcaggc tggcacatcc   2460

atatttgtat ggaaaaaaaa aaaaaagacc ctacgctacc acttcaaaaa gtgacatgaa   2520

gtgtagtatc ctggcccttc attgtcattc tctcatgatt tttgttttgt tttcaacaaa   2580

aattggttgg tcattaaata tatcatatgt taggcacagt gacctggtta ttttcacatg   2640

ttacttcatt ttcttatcaa attaaatgtt tgtgacatag taaa                    2684


<210>  93
<211>  550
<212>  PRT
<213>  Homo sapiens

<400>  93


Met Ser Gln Thr Ser Leu Lys Gln Lys Lys Asn Glu Pro Gly Met Arg 
1               5                   10                  15      


Ser Ser Lys Glu Ser Leu Glu Ala Glu Lys Arg Lys Glu Ser Asp Lys 
            20                  25                  30          


Thr Gly Val Arg Leu Ser Asn Gln Gly Ser Gln Glu Ser Ser Leu Arg 
        35                  40                  45              


Lys Thr Asp Ser Arg Gly Tyr Leu Val Arg Ser Gln Trp Ser Arg Ile 
    50                  55                  60                  


Ser Arg Ser Pro Ser Thr Lys Ala Pro Ser Ile Asp Glu Pro Arg Ser 
65                  70                  75                  80  


Arg Asn Thr Ser Ala Lys Leu Pro Ser Ser Ser Thr Ser Ser Arg Thr 
                85                  90                  95      


Pro Ser Thr Ser Pro Ser Leu His Asp Ser Ser Pro Pro Pro Leu Ser 
            100                 105                 110         


Gly Gln Pro Ser Leu Gln Pro Pro Ala Ser Pro Gln Leu Pro Arg Ser 
        115                 120                 125             


Leu Asp Ser Arg Pro Pro Thr Pro Pro Glu Pro Asp Pro Gly Ser Arg 
    130                 135                 140                 


Arg Ser Thr Lys Met Gln Glu Asn Pro Glu Ala Trp Ala Gln Gly Ile 
145                 150                 155                 160 


Val Arg Glu Ile Arg Gln Thr Arg Asp Ser Gln Pro Leu Glu Tyr Ser 
                165                 170                 175     


Arg Thr Ser Pro Thr Glu Trp Lys Ser Ser Ser Gln Arg Arg Gly Ile 
            180                 185                 190         


Tyr Pro Ala Ser Thr Gln Leu Asp Arg Asn Ser Leu Ser Glu Gln Gln 
        195                 200                 205             


Gln Gln Gln Arg Glu Asp Glu Asp Asp Tyr Glu Ala Ala Tyr Trp Ala 
    210                 215                 220                 


Ser Met Arg Ser Phe Tyr Glu Lys Asn Pro Ser Cys Ser Arg Pro Trp 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asn Ala Ile Thr Ile Ala Leu Ser Ser Cys Ala 
                245                 250                 255     


Leu Phe Asn Met Val Asp Gly Arg Lys Ile Tyr Glu Gln Glu Gly Leu 
            260                 265                 270         


Glu Lys Tyr Met Glu Tyr Gln Leu Thr Asn Glu Asn Val Ile Leu Thr 
        275                 280                 285             


Pro Gly Pro Ala Phe Arg Phe Val Lys Ala Leu Gln Tyr Val Asn Ala 
    290                 295                 300                 


Arg Leu Arg Asp Leu Tyr Pro Asp Glu Gln Asp Leu Phe Asp Ile Val 
305                 310                 315                 320 


Leu Met Thr Asn Asn His Ala Gln Val Gly Val Arg Leu Ile Asn Ser 
                325                 330                 335     


Val Asn His Tyr Gly Leu Leu Ile Asp Arg Phe Cys Leu Thr Gly Gly 
            340                 345                 350         


Lys Asp Pro Ile Gly Tyr Leu Lys Ala Tyr Leu Thr Asn Leu Tyr Ile 
        355                 360                 365             


Ala Ala Asp Ser Glu Lys Val Gln Glu Ala Ile Gln Glu Gly Ile Ala 
    370                 375                 380                 


Ser Ala Thr Met Phe Asp Gly Ala Lys Asp Met Ala Tyr Cys Asp Thr 
385                 390                 395                 400 


Gln Leu Arg Val Ala Phe Asp Gly Asp Ala Val Leu Phe Ser Asp Glu 
                405                 410                 415     


Ser Glu His Phe Thr Lys Glu His Gly Leu Asp Lys Phe Phe Gln Tyr 
            420                 425                 430         


Asp Thr Leu Cys Glu Ser Lys Pro Leu Ala Gln Gly Pro Leu Lys Gly 
        435                 440                 445             


Phe Leu Glu Asp Leu Gly Arg Leu Gln Lys Lys Phe Tyr Ala Lys Asn 
    450                 455                 460                 


Glu Arg Leu Leu Cys Pro Ile Arg Thr Tyr Leu Val Thr Ala Arg Ser 
465                 470                 475                 480 


Ala Ala Ser Ser Gly Ala Arg Val Leu Lys Thr Leu Arg Arg Trp Gly 
                485                 490                 495     


Leu Glu Ile Asp Glu Ala Leu Phe Leu Ala Gly Ala Pro Lys Ser Pro 
            500                 505                 510         


Ile Leu Val Lys Ile Arg Pro His Ile Phe Phe Asp Asp His Met Phe 
        515                 520                 525             


His Ile Glu Gly Ala Gln Arg Leu Gly Ser Ile Ala Ala Tyr Gly Phe 
    530                 535                 540                 


Asn Lys Lys Phe Ser Ser 
545                 550 

<210>  94
<211>  4422
<212>  DNA
<213>  Homo sapiens

<400>  94
cgcagagcgc gcacccaagc ggccggacct ccccgactcc cgggccgccc ccgtctcgcg     60

ccctgcctcc ctccttcggc cttcacctac ccgcctccgg attggccgct aggaatcccg    120

cccctctaaa gccctgcctg ctattggtca cgattttata atcaatggat aaagtgggaa    180

aaatgtggaa taacttcaaa tacaggtgtc agaatctctt cggtcatgag ggaggaagcc    240

gtagtgaaaa tgtggacatg aactccaaca gatgtttgtc tgtcaaagag aaaaacatca    300

gcataggaga ctcaactcct cagcaacaaa gcagtccctt aagagaaaat attgccttac    360

aactgggatt aagcccttcg aagaattctt caaggagaaa tcaaaattgt gccacagaaa    420

tccctcaaat tgttgaaata agcatcgaaa aggataatga ttcttgtgtt accccaggaa    480

caagacttgc acgaagagat tcctactctc gacatgctcc atggggtggg aagaaaaaac    540

attcctgttc tacaaagacc cagagttcat tggatgctga taaaaagttt ggtagaactc    600

gaagtggact tcaaaggaga gagaggcgct acggcgtaag ttctgtacac gacatggaca    660

gtgtttccag cagaactgta ggaagtcgct ctctaagaca gaggttgcag gatactgtgg    720

gcttgtgttt tcccatgaga acttacagca agcagtcaaa gcctctcttt tccaataaaa    780

gaaaaatcca tctctctgaa ttaatgcttg agaaatgccc ttttcctgct ggctcagatt    840

tagcccaaaa atggcatttg attaaacagc atacagctcc tgtgagccca cattcaacat    900

tttttgatac atttgatcca tctttggttt ctacagaaga tgaagaagat aggcttagag    960

agagaaggcg gcttagtatt gaagaagggg ttgatccccc tcccaatgca caaatacata   1020

catttgaagc tactgcacag gttaatccat tatataaact gggaccaaaa ttagctcctg   1080

gaatgactga aataagtggg gacagttctg caattccaca agctaattgt gactcggaag   1140

aggatacaac caccctgtgt ttgcagtcac ggaggcagaa gcagcgtcag atatctggag   1200

acagccatac ccatgttagc agacagggag cttggaaagt ccacacacag attgattaca   1260

tacactgcct cgtgcctgat ttgcttcaaa ttacagggaa tccctgttac tggggagtga   1320

tggaccgtta tgaagcagaa gcccttctcg aagggaaacc tgaaggcacg tttttgctca   1380

gggactctgc gcaagaggac tacctcttct ctgtgagctt ccgccgctac aacagatccc   1440

tgcatgcccg aattgagcag tggaatcaca actttagttt cgacgcccat gacccgtgtg   1500

tatttcactc ctccactgta acgggacttt tagaacatta taaagatccc agttcgtgca   1560

tgttttttga accattgctt actatatcac taaataggac tttccctttt agcctgcagt   1620

atatctgtcg cgcggtaatc tgcaggtgca ctacgtatga tggaattgat gggctccctc   1680

taccctcaat gttacaggat tttttaaaag agtatcatta taaacaaaaa gttagagttc   1740

gctggttgga acgagaacca gtcaaggcaa agtaaactct ccggtcccca aaggttgtta   1800

actaggtccg ctttcatgtg catcagacag tacacctata gcaagcacac gtagcagtgt   1860

taggcttttt catacagtat gtaagcttag tgttagtatc tgtcagatgc tacctgctgt   1920

tacttattca gataaacatg gtgcctattg gaacaatagc ggatagagct acaggtgttc   1980

agtaagacta caaaaacatt ttgcctattt cgctaacagt ttggttttta atggctgtgg   2040

tatttgagtg aggcaactct ggggcatttg ttatgaagaa ttctatttct tactgaagaa   2100

caaattatta atattggatg agtatttcaa cagtgtgact aatgtttgaa attatttttt   2160

ctaagagttt ttctataacc ttccaaaagt cgtgatgttt gtagttacta taaatcaagc   2220

tttggaagtc caaaaagaat aaaagactgc cttcctttta gaaaaaaatg caattttctg   2280

gccacaaggg catagtgcag ttcacttacg tgttgatgta gtttataatc agacgccttt   2340

tctcttctgc aaaaggtact gttaagtaaa ccagattttc taaataggca ttcttaaaat   2400

ttcagactta caaagctagt agtagaattt tattgaaagg cctaggtatt aattttttaa   2460

atgagtgctt taacttaaaa caggcgtttg gaatagctgc tgcaatgtag tcttgtgtgt   2520

gatttttttt taagttgatg tgcagtctaa ttgttgtttc ataaaagttg gatctgttcc   2580

tatgcccagg atgattttgt gaaccgtgaa gtacgtgaga ctagaagacg cccaaacaag   2640

tcagataata gtaactacaa tggttgctga tgttgagatt attgttgaac tataattaat   2700

aatttggatg gcagaattta tctctttttt gtaaactctc ataactgaat tgcttaagta   2760

taatttatag aatttcagtg cagttcattc ttaatggaaa atctgaaacc taaattgcag   2820

atttaaaagg tactgtacaa ccattatatc tgtaaataac ttagcacctt tttgtcactt   2880

agaataatat gtactactac ttgagtgagc gcttttggaa gttatatcaa gttctagtgt   2940

ttgcttctta gtaactgaac tgaatttaca gttctgtcct agacattttg cactaaagta   3000

gccgaatcca ctctcatgtc ttttcgttaa tgtgctctgt accactggtg agtgctccat   3060

agtttcctta cctgctgcta cagaatgtta ttttacatcc ctatggctat tgccaaggct   3120

acaaaaaagg aaagctatat ttgtatgcaa cactaacctt ttgactgcta atgtatgttt   3180

ctgcttgctg tgccttgtta tggctgcttt ttttgtgcta ataaagtatg tttggtgttc   3240

tccttgtata tctgctgttt tatacatttg caacaatttc tcttgtaaat ggaatggttt   3300

ggggttttta aataagcatt aactaacaac ctttctatag ttaatgcaga gttaatgaac   3360

agtctaatat tgacttatca gaataagcta actctaaatt taatgctcta catcttatca   3420

gtcataatta tatatactgt ggaacagtat ctgtagttac tgcaaattac tgtacagttt   3480

aggttataac agaaaactga cagagaagta ataaacctat tgatttctct gcttataaat   3540

gaaagattga aactatccaa tgacatatta tagtaaatga gtatctgtaa cctcccactg   3600

catcagaagc aggttaaatg aagtcttgtg aatttgtaat agatcagtac catttattgg   3660

tttggggacc atcttaatta aaaataaatg cccaaaatgt agaactttaa ccaaagactt   3720

gtccctttta aagcaaaatg gggattgaag ggacttataa tttctgttgt ttctaattaa   3780

agtccctgaa gatcatatac caaagtgttt gagaacttca tccaaaccta ctttaaagca   3840

ttatgtgcaa ttaagttgtt atgacataat tatattgcct aattgttggg tcttttttct   3900

tgagcttata atgtacctgg aaaataaacc tcttgagaaa aagaaaagtt catactgatt   3960

attggaaaag gactatatat gtgagcaaga ttgtgtttta gagaggaaac ttgaaactcc   4020

aagaaagcac ttgatgtttt tatatgcttg tagcaaattg atgttctaac tgtagtttta   4080

tagaaagtat taatgctttt atgtatttca aaactttcat atgttaaatg gaaattgttt   4140

taaatgtgtt tgagtttatg taagcatgta tacactgtgc taaaagtcac atgtttcagt   4200

ttgtgtataa tattaatatg caatttttgg tttaaatttt tgtcttaaaa tattagtggc   4260

ttacatttta aaaaagaaaa atcaccagca tgaacttgca cctaagtcta tattcactgt   4320

gtccttttct gaatcccatt gtagcctgtc aactaaattt gagtgttaac ggtcttttta   4380

aagtgcattt aaatacaaac caggaatttc tttagaagtt ga                      4422


<210>  95
<211>  536
<212>  PRT
<213>  Homo sapiens

<400>  95


Met Asp Lys Val Gly Lys Met Trp Asn Asn Phe Lys Tyr Arg Cys Gln 
1               5                   10                  15      


Asn Leu Phe Gly His Glu Gly Gly Ser Arg Ser Glu Asn Val Asp Met 
            20                  25                  30          


Asn Ser Asn Arg Cys Leu Ser Val Lys Glu Lys Asn Ile Ser Ile Gly 
        35                  40                  45              


Asp Ser Thr Pro Gln Gln Gln Ser Ser Pro Leu Arg Glu Asn Ile Ala 
    50                  55                  60                  


Leu Gln Leu Gly Leu Ser Pro Ser Lys Asn Ser Ser Arg Arg Asn Gln 
65                  70                  75                  80  


Asn Cys Ala Thr Glu Ile Pro Gln Ile Val Glu Ile Ser Ile Glu Lys 
                85                  90                  95      


Asp Asn Asp Ser Cys Val Thr Pro Gly Thr Arg Leu Ala Arg Arg Asp 
            100                 105                 110         


Ser Tyr Ser Arg His Ala Pro Trp Gly Gly Lys Lys Lys His Ser Cys 
        115                 120                 125             


Ser Thr Lys Thr Gln Ser Ser Leu Asp Ala Asp Lys Lys Phe Gly Arg 
    130                 135                 140                 


Thr Arg Ser Gly Leu Gln Arg Arg Glu Arg Arg Tyr Gly Val Ser Ser 
145                 150                 155                 160 


Val His Asp Met Asp Ser Val Ser Ser Arg Thr Val Gly Ser Arg Ser 
                165                 170                 175     


Leu Arg Gln Arg Leu Gln Asp Thr Val Gly Leu Cys Phe Pro Met Arg 
            180                 185                 190         


Thr Tyr Ser Lys Gln Ser Lys Pro Leu Phe Ser Asn Lys Arg Lys Ile 
        195                 200                 205             


His Leu Ser Glu Leu Met Leu Glu Lys Cys Pro Phe Pro Ala Gly Ser 
    210                 215                 220                 


Asp Leu Ala Gln Lys Trp His Leu Ile Lys Gln His Thr Ala Pro Val 
225                 230                 235                 240 


Ser Pro His Ser Thr Phe Phe Asp Thr Phe Asp Pro Ser Leu Val Ser 
                245                 250                 255     


Thr Glu Asp Glu Glu Asp Arg Leu Arg Glu Arg Arg Arg Leu Ser Ile 
            260                 265                 270         


Glu Glu Gly Val Asp Pro Pro Pro Asn Ala Gln Ile His Thr Phe Glu 
        275                 280                 285             


Ala Thr Ala Gln Val Asn Pro Leu Tyr Lys Leu Gly Pro Lys Leu Ala 
    290                 295                 300                 


Pro Gly Met Thr Glu Ile Ser Gly Asp Ser Ser Ala Ile Pro Gln Ala 
305                 310                 315                 320 


Asn Cys Asp Ser Glu Glu Asp Thr Thr Thr Leu Cys Leu Gln Ser Arg 
                325                 330                 335     


Arg Gln Lys Gln Arg Gln Ile Ser Gly Asp Ser His Thr His Val Ser 
            340                 345                 350         


Arg Gln Gly Ala Trp Lys Val His Thr Gln Ile Asp Tyr Ile His Cys 
        355                 360                 365             


Leu Val Pro Asp Leu Leu Gln Ile Thr Gly Asn Pro Cys Tyr Trp Gly 
    370                 375                 380                 


Val Met Asp Arg Tyr Glu Ala Glu Ala Leu Leu Glu Gly Lys Pro Glu 
385                 390                 395                 400 


Gly Thr Phe Leu Leu Arg Asp Ser Ala Gln Glu Asp Tyr Leu Phe Ser 
                405                 410                 415     


Val Ser Phe Arg Arg Tyr Asn Arg Ser Leu His Ala Arg Ile Glu Gln 
            420                 425                 430         


Trp Asn His Asn Phe Ser Phe Asp Ala His Asp Pro Cys Val Phe His 
        435                 440                 445             


Ser Ser Thr Val Thr Gly Leu Leu Glu His Tyr Lys Asp Pro Ser Ser 
    450                 455                 460                 


Cys Met Phe Phe Glu Pro Leu Leu Thr Ile Ser Leu Asn Arg Thr Phe 
465                 470                 475                 480 


Pro Phe Ser Leu Gln Tyr Ile Cys Arg Ala Val Ile Cys Arg Cys Thr 
                485                 490                 495     


Thr Tyr Asp Gly Ile Asp Gly Leu Pro Leu Pro Ser Met Leu Gln Asp 
            500                 505                 510         


Phe Leu Lys Glu Tyr His Tyr Lys Gln Lys Val Arg Val Arg Trp Leu 
        515                 520                 525             


Glu Arg Glu Pro Val Lys Ala Lys 
    530                 535     

<210>  96
<211>  4510
<212>  DNA
<213>  Homo sapiens

<400>  96
ggaaacgggt gaagaagggg aggcggcagg gaagggggtg ggggcctggc gggggcatcc     60

ggcggagctg gggtccccgg gctccgtccg gaggaagcga cgctgcgctc gctgggcagt    120

cggaggggac gggacgcacc ggagggcagg cggactcgcc ctgtcggtga ctgcgccgtc    180

cgggcccgtc ctgcctggcc gcaggtgccc tggatgaggc cgccccgcgc gccccaaacg    240

attttataat caatggataa agtgggaaaa atgtggaata acttcaaata caggtgtcag    300

aatctcttcg gtcatgaggg aggaagccgt agtgaaaatg tggacatgaa ctccaacaga    360

tgtttgtctg tcaaagagaa aaacatcagc ataggagact caactcctca gcaacaaagc    420

agtcccttaa gagaaaatat tgccttacaa ctgggattaa gcccttcgaa gaattcttca    480

aggagaaatc aaaattgtgc cacagaaatc cctcaaattg ttgaaataag catcgaaaag    540

gataatgatt cttgtgttac cccaggaaca agacttgcac gaagagattc ctactctcga    600

catgctccat ggggtgggaa gaaaaaacat tcctgttcta caaagaccca gagttcattg    660

gatgctgata aaaagtttgg tagaactcga agtggacttc aaaggagaga gaggcgctac    720

ggcgtaagtt ctgtacacga catggacagt gtttccagca gaactgtagg aagtcgctct    780

ctaagacaga ggttgcagga tactgtgggc ttgtgttttc ccatgagaac ttacagcaag    840

cagtcaaagc ctctcttttc caataaaaga aaaatccatc tctctgaatt aatgcttgag    900

aaatgccctt ttcctgctgg ctcagattta gcccaaaaat ggcatttgat taaacagcat    960

acagctcctg tgagcccaca ttcaacattt tttgatacat ttgatccatc tttggtttct   1020

acagaagatg aagaagatag gcttagagag agaaggcggc ttagtattga agaaggggtt   1080

gatccccctc ccaatgcaca aatacataca tttgaagcta ctgcacaggt taatccatta   1140

tataaactgg gaccaaaatt agctcctgga atgactgaaa taagtgggga cagttctgca   1200

attccacaag ctaattgtga ctcggaagag gatacaacca ccctgtgttt gcagtcacgg   1260

aggcagaagc agcgtcagat atctggagac agccataccc atgttagcag acagggagct   1320

tggaaagtcc acacacagat tgattacata cactgcctcg tgcctgattt gcttcaaatt   1380

acagggaatc cctgttactg gggagtgatg gaccgttatg aagcagaagc ccttctcgaa   1440

gggaaacctg aaggcacgtt tttgctcagg gactctgcgc aagaggacta cctcttctct   1500

gtgagcttcc gccgctacaa cagatccctg catgcccgaa ttgagcagtg gaatcacaac   1560

tttagtttcg acgcccatga cccgtgtgta tttcactcct ccactgtaac gggactttta   1620

gaacattata aagatcccag ttcgtgcatg ttttttgaac cattgcttac tatatcacta   1680

aataggactt tcccttttag cctgcagtat atctgtcgcg cggtaatctg caggtgcact   1740

acgtatgatg gaattgatgg gctccctcta ccctcaatgt tacaggattt tttaaaagag   1800

tatcattata aacaaaaagt tagagttcgc tggttggaac gagaaccagt caaggcaaag   1860

taaactctcc ggtccccaaa ggttgttaac taggtccgct ttcatgtgca tcagacagta   1920

cacctatagc aagcacacgt agcagtgtta ggctttttca tacagtatgt aagcttagtg   1980

ttagtatctg tcagatgcta cctgctgtta cttattcaga taaacatggt gcctattgga   2040

acaatagcgg atagagctac aggtgttcag taagactaca aaaacatttt gcctatttcg   2100

ctaacagttt ggtttttaat ggctgtggta tttgagtgag gcaactctgg ggcatttgtt   2160

atgaagaatt ctatttctta ctgaagaaca aattattaat attggatgag tatttcaaca   2220

gtgtgactaa tgtttgaaat tattttttct aagagttttt ctataacctt ccaaaagtcg   2280

tgatgtttgt agttactata aatcaagctt tggaagtcca aaaagaataa aagactgcct   2340

tccttttaga aaaaaatgca attttctggc cacaagggca tagtgcagtt cacttacgtg   2400

ttgatgtagt ttataatcag acgccttttc tcttctgcaa aaggtactgt taagtaaacc   2460

agattttcta aataggcatt cttaaaattt cagacttaca aagctagtag tagaatttta   2520

ttgaaaggcc taggtattaa ttttttaaat gagtgcttta acttaaaaca ggcgtttgga   2580

atagctgctg caatgtagtc ttgtgtgtga ttttttttta agttgatgtg cagtctaatt   2640

gttgtttcat aaaagttgga tctgttccta tgcccaggat gattttgtga accgtgaagt   2700

acgtgagact agaagacgcc caaacaagtc agataatagt aactacaatg gttgctgatg   2760

ttgagattat tgttgaacta taattaataa tttggatggc agaatttatc tcttttttgt   2820

aaactctcat aactgaattg cttaagtata atttatagaa tttcagtgca gttcattctt   2880

aatggaaaat ctgaaaccta aattgcagat ttaaaaggta ctgtacaacc attatatctg   2940

taaataactt agcacctttt tgtcacttag aataatatgt actactactt gagtgagcgc   3000

ttttggaagt tatatcaagt tctagtgttt gcttcttagt aactgaactg aatttacagt   3060

tctgtcctag acattttgca ctaaagtagc cgaatccact ctcatgtctt ttcgttaatg   3120

tgctctgtac cactggtgag tgctccatag tttccttacc tgctgctaca gaatgttatt   3180

ttacatccct atggctattg ccaaggctac aaaaaaggaa agctatattt gtatgcaaca   3240

ctaacctttt gactgctaat gtatgtttct gcttgctgtg ccttgttatg gctgcttttt   3300

ttgtgctaat aaagtatgtt tggtgttctc cttgtatatc tgctgtttta tacatttgca   3360

acaatttctc ttgtaaatgg aatggtttgg ggtttttaaa taagcattaa ctaacaacct   3420

ttctatagtt aatgcagagt taatgaacag tctaatattg acttatcaga ataagctaac   3480

tctaaattta atgctctaca tcttatcagt cataattata tatactgtgg aacagtatct   3540

gtagttactg caaattactg tacagtttag gttataacag aaaactgaca gagaagtaat   3600

aaacctattg atttctctgc ttataaatga aagattgaaa ctatccaatg acatattata   3660

gtaaatgagt atctgtaacc tcccactgca tcagaagcag gttaaatgaa gtcttgtgaa   3720

tttgtaatag atcagtacca tttattggtt tggggaccat cttaattaaa aataaatgcc   3780

caaaatgtag aactttaacc aaagacttgt cccttttaaa gcaaaatggg gattgaaggg   3840

acttataatt tctgttgttt ctaattaaag tccctgaaga tcatatacca aagtgtttga   3900

gaacttcatc caaacctact ttaaagcatt atgtgcaatt aagttgttat gacataatta   3960

tattgcctaa ttgttgggtc ttttttcttg agcttataat gtacctggaa aataaacctc   4020

ttgagaaaaa gaaaagttca tactgattat tggaaaagga ctatatatgt gagcaagatt   4080

gtgttttaga gaggaaactt gaaactccaa gaaagcactt gatgttttta tatgcttgta   4140

gcaaattgat gttctaactg tagttttata gaaagtatta atgcttttat gtatttcaaa   4200

actttcatat gttaaatgga aattgtttta aatgtgtttg agtttatgta agcatgtata   4260

cactgtgcta aaagtcacat gtttcagttt gtgtataata ttaatatgca atttttggtt   4320

taaatttttg tcttaaaata ttagtggctt acattttaaa aaagaaaaat caccagcatg   4380

aacttgcacc taagtctata ttcactgtgt ccttttctga atcccattgt agcctgtcaa   4440

ctaaatttga gtgttaacgg tctttttaaa gtgcatttaa atacaaacca ggaatttctt   4500

tagaagttga                                                          4510


<210>  97
<211>  536
<212>  PRT
<213>  Homo sapiens

<400>  97


Met Asp Lys Val Gly Lys Met Trp Asn Asn Phe Lys Tyr Arg Cys Gln 
1               5                   10                  15      


Asn Leu Phe Gly His Glu Gly Gly Ser Arg Ser Glu Asn Val Asp Met 
            20                  25                  30          


Asn Ser Asn Arg Cys Leu Ser Val Lys Glu Lys Asn Ile Ser Ile Gly 
        35                  40                  45              


Asp Ser Thr Pro Gln Gln Gln Ser Ser Pro Leu Arg Glu Asn Ile Ala 
    50                  55                  60                  


Leu Gln Leu Gly Leu Ser Pro Ser Lys Asn Ser Ser Arg Arg Asn Gln 
65                  70                  75                  80  


Asn Cys Ala Thr Glu Ile Pro Gln Ile Val Glu Ile Ser Ile Glu Lys 
                85                  90                  95      


Asp Asn Asp Ser Cys Val Thr Pro Gly Thr Arg Leu Ala Arg Arg Asp 
            100                 105                 110         


Ser Tyr Ser Arg His Ala Pro Trp Gly Gly Lys Lys Lys His Ser Cys 
        115                 120                 125             


Ser Thr Lys Thr Gln Ser Ser Leu Asp Ala Asp Lys Lys Phe Gly Arg 
    130                 135                 140                 


Thr Arg Ser Gly Leu Gln Arg Arg Glu Arg Arg Tyr Gly Val Ser Ser 
145                 150                 155                 160 


Val His Asp Met Asp Ser Val Ser Ser Arg Thr Val Gly Ser Arg Ser 
                165                 170                 175     


Leu Arg Gln Arg Leu Gln Asp Thr Val Gly Leu Cys Phe Pro Met Arg 
            180                 185                 190         


Thr Tyr Ser Lys Gln Ser Lys Pro Leu Phe Ser Asn Lys Arg Lys Ile 
        195                 200                 205             


His Leu Ser Glu Leu Met Leu Glu Lys Cys Pro Phe Pro Ala Gly Ser 
    210                 215                 220                 


Asp Leu Ala Gln Lys Trp His Leu Ile Lys Gln His Thr Ala Pro Val 
225                 230                 235                 240 


Ser Pro His Ser Thr Phe Phe Asp Thr Phe Asp Pro Ser Leu Val Ser 
                245                 250                 255     


Thr Glu Asp Glu Glu Asp Arg Leu Arg Glu Arg Arg Arg Leu Ser Ile 
            260                 265                 270         


Glu Glu Gly Val Asp Pro Pro Pro Asn Ala Gln Ile His Thr Phe Glu 
        275                 280                 285             


Ala Thr Ala Gln Val Asn Pro Leu Tyr Lys Leu Gly Pro Lys Leu Ala 
    290                 295                 300                 


Pro Gly Met Thr Glu Ile Ser Gly Asp Ser Ser Ala Ile Pro Gln Ala 
305                 310                 315                 320 


Asn Cys Asp Ser Glu Glu Asp Thr Thr Thr Leu Cys Leu Gln Ser Arg 
                325                 330                 335     


Arg Gln Lys Gln Arg Gln Ile Ser Gly Asp Ser His Thr His Val Ser 
            340                 345                 350         


Arg Gln Gly Ala Trp Lys Val His Thr Gln Ile Asp Tyr Ile His Cys 
        355                 360                 365             


Leu Val Pro Asp Leu Leu Gln Ile Thr Gly Asn Pro Cys Tyr Trp Gly 
    370                 375                 380                 


Val Met Asp Arg Tyr Glu Ala Glu Ala Leu Leu Glu Gly Lys Pro Glu 
385                 390                 395                 400 


Gly Thr Phe Leu Leu Arg Asp Ser Ala Gln Glu Asp Tyr Leu Phe Ser 
                405                 410                 415     


Val Ser Phe Arg Arg Tyr Asn Arg Ser Leu His Ala Arg Ile Glu Gln 
            420                 425                 430         


Trp Asn His Asn Phe Ser Phe Asp Ala His Asp Pro Cys Val Phe His 
        435                 440                 445             


Ser Ser Thr Val Thr Gly Leu Leu Glu His Tyr Lys Asp Pro Ser Ser 
    450                 455                 460                 


Cys Met Phe Phe Glu Pro Leu Leu Thr Ile Ser Leu Asn Arg Thr Phe 
465                 470                 475                 480 


Pro Phe Ser Leu Gln Tyr Ile Cys Arg Ala Val Ile Cys Arg Cys Thr 
                485                 490                 495     


Thr Tyr Asp Gly Ile Asp Gly Leu Pro Leu Pro Ser Met Leu Gln Asp 
            500                 505                 510         


Phe Leu Lys Glu Tyr His Tyr Lys Gln Lys Val Arg Val Arg Trp Leu 
        515                 520                 525             


Glu Arg Glu Pro Val Lys Ala Lys 
    530                 535     

<210>  98
<211>  565
<212>  DNA
<213>  Homo sapiens

<400>  98
ggaacagggg atcctctggt cagtctaggt cccctaccca tctctatgtg cggtgtgagg     60

tgctctgccc tacccacact gagggagtga ccttagttaa acagagacta gggaaagaat    120

gccaggaagc gggacaacac ctacctacta cctggactgc aaaaagaggg tgctcatgct    180

atcttaagtg aaaggaatct ccaggacaga ggcatgaaaa tgtgtccgga attggtgggt    240

tcttggtctc actgacttca agaatgaagc cgtggacact cgcagtgagt gttacagctc    300

ttaaggtggc gcgtctggag tttgttcctt ctgatgttcg gatatgttcg gagtttcttc    360

cttgtcgtgg gttcgtggtc tcgctggctc aggagtgaag ctgcatacct tcgcgcctcc    420

aaatggaatg aggaaagaag tgacaggctc catgggctgg aactcaggag acccaagttc    480

aagtcccagc actaccactt accaggcgag tgattctggg acagttaccg tgcaatgaga    540

gcaagcaact tcagaatttc tttcg                                          565


<210>  99
<211>  64
<212>  PRT
<213>  Homo sapiens

<400>  99


Met Phe Gly Val Ser Ser Leu Ser Trp Val Arg Gly Leu Ala Gly Ser 
1               5                   10                  15      


Gly Val Lys Leu His Thr Phe Ala Pro Pro Asn Gly Met Arg Lys Glu 
            20                  25                  30          


Val Thr Gly Ser Met Gly Trp Asn Ser Gly Asp Pro Ser Ser Ser Pro 
        35                  40                  45              


Ser Thr Thr Thr Tyr Gln Ala Ser Asp Ser Gly Thr Val Thr Val Gln 
    50                  55                  60                  

<210>  100
<211>  1802
<212>  DNA
<213>  Homo sapiens

<400>  100
gggcagctcc accctgggag ggactgtggc ccaggtactg cccgggtgct actttatggg     60

cagcagctca gttgagttag agtctggaag acctcagaag acctcctgtc ctatgaggcc    120

ctccccatgg ctttagagac gatctgccga ccctctggga gaaaatccag caagatgcaa    180

gccttcagaa tctgggatgt taaccagaag accttctatc tgaggaacaa ccaactagtt    240

gctggatact tgcaaggacc aaatgtcaat ttagaagaaa agatagatgt ggtacccatt    300

gagcctcatg ctctgttctt gggaatccat ggagggaaga tgtgcctgtc ctgtgtcaag    360

tctggtgatg agaccagact ccagctggag gcagttaaca tcactgacct gagcgagaac    420

agaaagcagg acaagcgctt cgccttcatc cgctcagaca gcggccccac caccagtttt    480

gagtctgccg cctgccccgg ttggttcctc tgcacagcga tggaagctga ccagcccgtc    540

agcctcacca atatgcctga cgaaggcgtc atggtcacca aattctactt ccaggaggac    600

gagtagtact gcccaggcct gcctgttccc attcttgcat ggcaaggact gcagggactg    660

ccagtccccc tgccccaggg ctcccggcta tgggggcact gaggaccagc cattgagggg    720

tggaccctca gaaggcgtca caagaacctg gtcacaggac tctgcctcct cttcaactga    780

ccagcctcca tgctgcctcc agaatggtct ttctaatgtg tgaatcagag cacagcagcc    840

cctgcacaaa gcccttccat gtcgcctctg cattcaggat caaaccccga ccacctgccc    900

aacctgctct cctcttgcca ctgcctcttc ctccctcatt ccaccttccc atgccctgga    960

tccatcaggc cacttgatga cccccaacca agtggctccc acaccctgtt ttacaaaaaa   1020

gaaaagacca gtccatgagg gaggttttta agggtttgtg gaaaatgaaa attaggattt   1080

catgattttt ttttttcagt ccccgtgaag gagagccctt catttggaga ttatgttctt   1140

tcggggagag gctgaggact taaaatattc ctgcatttgt gaaatgatgg tgaaagtaag   1200

tggtagcttt tcccttcttt ttcttctttt tttgtgatgt cccaacttgt aaaaattaaa   1260

agttatggta ctatgttagc cccataattt tttttttcct tttaaaacac ttccataatc   1320

tggactcctc tgtccaggca ctgctgccca gcctccaagc tccatctcca ctccagattt   1380

tttacagctg cctgcagtac tttacctcct atcagaagtt tctcagctcc caaggctctg   1440

agcaaatgtg gctcctgggg gttctttctt cctctgctga aggaataaat tgctccttga   1500

cattgtagag cttctggcac ttggagactt gtatgaaaga tggctgtgcc tctgcctgtc   1560

tcccccaccg ggctgggagc tctgcagagc aggaaacatg actcgtatat gtctcaggtc   1620

cctgcagggc caagcaccta gcctcgctct tggcaggtac tcagcgaatg aatgctgtat   1680

atgttgggtg caaagttccc tacttcctgt gacttcagct ctgttttaca ataaaatctt   1740

gaaaatgcct aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   1800

aa                                                                  1802


<210>  101
<211>  159
<212>  PRT
<213>  Homo sapiens

<400>  101


Met Ala Leu Glu Thr Ile Cys Arg Pro Ser Gly Arg Lys Ser Ser Lys 
1               5                   10                  15      


Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu 
            20                  25                  30          


Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn 
        35                  40                  45              


Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala Leu Phe 
    50                  55                  60                  


Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val Lys Ser Gly 
65                  70                  75                  80  


Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp Leu Ser 
                85                  90                  95      


Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser 
            100                 105                 110         


Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp Phe Leu 
        115                 120                 125             


Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn Met Pro 
    130                 135                 140                 


Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
145                 150                 155                 

<210>  102
<211>  1865
<212>  DNA
<213>  Homo sapiens

<400>  102
gggcagctcc accctgggag ggactgtggc ccaggtactg cccgggtgct actttatggg     60

cagcagctca gttgagttag agtctggaag acctcagaag acctcctgtc ctatgaggcc    120

ctccccatgg ctttagctga cttgtatgaa gaaggaggtg gaggaggagg agaaggtgaa    180

gacaatgctg actcaaagga gacgatctgc cgaccctctg ggagaaaatc cagcaagatg    240

caagccttca gaatctggga tgttaaccag aagaccttct atctgaggaa caaccaacta    300

gttgctggat acttgcaagg accaaatgtc aatttagaag aaaagataga tgtggtaccc    360

attgagcctc atgctctgtt cttgggaatc catggaggga agatgtgcct gtcctgtgtc    420

aagtctggtg atgagaccag actccagctg gaggcagtta acatcactga cctgagcgag    480

aacagaaagc aggacaagcg cttcgccttc atccgctcag acagcggccc caccaccagt    540

tttgagtctg ccgcctgccc cggttggttc ctctgcacag cgatggaagc tgaccagccc    600

gtcagcctca ccaatatgcc tgacgaaggc gtcatggtca ccaaattcta cttccaggag    660

gacgagtagt actgcccagg cctgcctgtt cccattcttg catggcaagg actgcaggga    720

ctgccagtcc ccctgcccca gggctcccgg ctatgggggc actgaggacc agccattgag    780

gggtggaccc tcagaaggcg tcacaagaac ctggtcacag gactctgcct cctcttcaac    840

tgaccagcct ccatgctgcc tccagaatgg tctttctaat gtgtgaatca gagcacagca    900

gcccctgcac aaagcccttc catgtcgcct ctgcattcag gatcaaaccc cgaccacctg    960

cccaacctgc tctcctcttg ccactgcctc ttcctccctc attccacctt cccatgccct   1020

ggatccatca ggccacttga tgacccccaa ccaagtggct cccacaccct gttttacaaa   1080

aaagaaaaga ccagtccatg agggaggttt ttaagggttt gtggaaaatg aaaattagga   1140

tttcatgatt tttttttttc agtccccgtg aaggagagcc cttcatttgg agattatgtt   1200

ctttcgggga gaggctgagg acttaaaata ttcctgcatt tgtgaaatga tggtgaaagt   1260

aagtggtagc ttttcccttc tttttcttct ttttttgtga tgtcccaact tgtaaaaatt   1320

aaaagttatg gtactatgtt agccccataa tttttttttt ccttttaaaa cacttccata   1380

atctggactc ctctgtccag gcactgctgc ccagcctcca agctccatct ccactccaga   1440

ttttttacag ctgcctgcag tactttacct cctatcagaa gtttctcagc tcccaaggct   1500

ctgagcaaat gtggctcctg ggggttcttt cttcctctgc tgaaggaata aattgctcct   1560

tgacattgta gagcttctgg cacttggaga cttgtatgaa agatggctgt gcctctgcct   1620

gtctccccca ccgggctggg agctctgcag agcaggaaac atgactcgta tatgtctcag   1680

gtccctgcag ggccaagcac ctagcctcgc tcttggcagg tactcagcga atgaatgctg   1740

tatatgttgg gtgcaaagtt ccctacttcc tgtgacttca gctctgtttt acaataaaat   1800

cttgaaaatg cctaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   1860

aaaaa                                                               1865


<210>  103
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  103


Met Ala Leu Ala Asp Leu Tyr Glu Glu Gly Gly Gly Gly Gly Gly Glu 
1               5                   10                  15      


Gly Glu Asp Asn Ala Asp Ser Lys Glu Thr Ile Cys Arg Pro Ser Gly 
            20                  25                  30          


Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln 
        35                  40                  45              


Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln 
    50                  55                  60                  


Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu 
65                  70                  75                  80  


Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser 
                85                  90                  95      


Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn 
            100                 105                 110         


Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe 
        115                 120                 125             


Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys 
    130                 135                 140                 


Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser 
145                 150                 155                 160 


Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe 
                165                 170                 175     


Gln Glu Asp Glu 
            180 

<210>  104
<211>  1760
<212>  DNA
<213>  Homo sapiens

<400>  104
atttctttat aaaccacaac tctgggcccg caatggcagt ccactgcctt gctgcagtca     60

cagaatggaa atctgcagag gcctccgcag tcacctaatc actctcctcc tcttcctgtt    120

ccattcagag acgatctgcc gaccctctgg gagaaaatcc agcaagatgc aagccttcag    180

aatctgggat gttaaccaga agaccttcta tctgaggaac aaccaactag ttgctggata    240

cttgcaagga ccaaatgtca atttagaaga aaagatagat gtggtaccca ttgagcctca    300

tgctctgttc ttgggaatcc atggagggaa gatgtgcctg tcctgtgtca agtctggtga    360

tgagaccaga ctccagctgg aggcagttaa catcactgac ctgagcgaga acagaaagca    420

ggacaagcgc ttcgccttca tccgctcaga cagcggcccc accaccagtt ttgagtctgc    480

cgcctgcccc ggttggttcc tctgcacagc gatggaagct gaccagcccg tcagcctcac    540

caatatgcct gacgaaggcg tcatggtcac caaattctac ttccaggagg acgagtagta    600

ctgcccaggc ctgcctgttc ccattcttgc atggcaagga ctgcagggac tgccagtccc    660

cctgccccag ggctcccggc tatgggggca ctgaggacca gccattgagg ggtggaccct    720

cagaaggcgt cacaagaacc tggtcacagg actctgcctc ctcttcaact gaccagcctc    780

catgctgcct ccagaatggt ctttctaatg tgtgaatcag agcacagcag cccctgcaca    840

aagcccttcc atgtcgcctc tgcattcagg atcaaacccc gaccacctgc ccaacctgct    900

ctcctcttgc cactgcctct tcctccctca ttccaccttc ccatgccctg gatccatcag    960

gccacttgat gacccccaac caagtggctc ccacaccctg ttttacaaaa aagaaaagac   1020

cagtccatga gggaggtttt taagggtttg tggaaaatga aaattaggat ttcatgattt   1080

ttttttttca gtccccgtga aggagagccc ttcatttgga gattatgttc tttcggggag   1140

aggctgagga cttaaaatat tcctgcattt gtgaaatgat ggtgaaagta agtggtagct   1200

tttcccttct ttttcttctt tttttgtgat gtcccaactt gtaaaaatta aaagttatgg   1260

tactatgtta gccccataat tttttttttc cttttaaaac acttccataa tctggactcc   1320

tctgtccagg cactgctgcc cagcctccaa gctccatctc cactccagat tttttacagc   1380

tgcctgcagt actttacctc ctatcagaag tttctcagct cccaaggctc tgagcaaatg   1440

tggctcctgg gggttctttc ttcctctgct gaaggaataa attgctcctt gacattgtag   1500

agcttctggc acttggagac ttgtatgaaa gatggctgtg cctctgcctg tctcccccac   1560

cgggctggga gctctgcaga gcaggaaaca tgactcgtat atgtctcagg tccctgcagg   1620

gccaagcacc tagcctcgct cttggcaggt actcagcgaa tgaatgctgt atatgttggg   1680

tgcaaagttc cctacttcct gtgacttcag ctctgtttta caataaaatc ttgaaaatgc   1740

ctaaaaaaaa aaaaaaaaaa                                               1760


<210>  105
<211>  177
<212>  PRT
<213>  Homo sapiens

<400>  105


Met Glu Ile Cys Arg Gly Leu Arg Ser His Leu Ile Thr Leu Leu Leu 
1               5                   10                  15      


Phe Leu Phe His Ser Glu Thr Ile Cys Arg Pro Ser Gly Arg Lys Ser 
            20                  25                  30          


Ser Lys Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe 
        35                  40                  45              


Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn 
    50                  55                  60                  


Val Asn Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala 
65                  70                  75                  80  


Leu Phe Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val Lys 
                85                  90                  95      


Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp 
            100                 105                 110         


Leu Ser Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser 
        115                 120                 125             


Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp 
    130                 135                 140                 


Phe Leu Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn 
145                 150                 155                 160 


Met Pro Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp 
                165                 170                 175     


Glu 
    

<210>  106
<211>  1973
<212>  DNA
<213>  Homo sapiens

<400>  106
gggcagctcc accctgggag ggactgtggc ccaggtactg cccgggtgct actttatggg     60

cagcagctca gttgagttag agtctggaag acctcagaag acctcctgtc ctatgaggcc    120

ctccccatgg ctttaggggg attataaaac taatcatcaa agccaagaag gcaagagcaa    180

gcatgtaccg ctgaaaacac aagataactg cataagtaat gactttcagt gcagattcat    240

agctaaccca taaactgctg gggcaaaaat catcttggaa ggctctgaac ctcagaaagg    300

attcacaaga cgatctgccg accctctggg agaaaatcca gcaagatgca agccttcaga    360

atctgggatg ttaaccagaa gaccttctat ctgaggaaca accaactagt tgctggatac    420

ttgcaaggac caaatgtcaa tttagaagaa aagatagatg tggtacccat tgagcctcat    480

gctctgttct tgggaatcca tggagggaag atgtgcctgt cctgtgtcaa gtctggtgat    540

gagaccagac tccagctgga ggcagttaac atcactgacc tgagcgagaa cagaaagcag    600

gacaagcgct tcgccttcat ccgctcagac agcggcccca ccaccagttt tgagtctgcc    660

gcctgccccg gttggttcct ctgcacagcg atggaagctg accagcccgt cagcctcacc    720

aatatgcctg acgaaggcgt catggtcacc aaattctact tccaggagga cgagtagtac    780

tgcccaggcc tgcctgttcc cattcttgca tggcaaggac tgcagggact gccagtcccc    840

ctgccccagg gctcccggct atgggggcac tgaggaccag ccattgaggg gtggaccctc    900

agaaggcgtc acaagaacct ggtcacagga ctctgcctcc tcttcaactg accagcctcc    960

atgctgcctc cagaatggtc tttctaatgt gtgaatcaga gcacagcagc ccctgcacaa   1020

agcccttcca tgtcgcctct gcattcagga tcaaaccccg accacctgcc caacctgctc   1080

tcctcttgcc actgcctctt cctccctcat tccaccttcc catgccctgg atccatcagg   1140

ccacttgatg acccccaacc aagtggctcc cacaccctgt tttacaaaaa agaaaagacc   1200

agtccatgag ggaggttttt aagggtttgt ggaaaatgaa aattaggatt tcatgatttt   1260

tttttttcag tccccgtgaa ggagagccct tcatttggag attatgttct ttcggggaga   1320

ggctgaggac ttaaaatatt cctgcatttg tgaaatgatg gtgaaagtaa gtggtagctt   1380

ttcccttctt tttcttcttt ttttgtgatg tcccaacttg taaaaattaa aagttatggt   1440

actatgttag ccccataatt ttttttttcc ttttaaaaca cttccataat ctggactcct   1500

ctgtccaggc actgctgccc agcctccaag ctccatctcc actccagatt ttttacagct   1560

gcctgcagta ctttacctcc tatcagaagt ttctcagctc ccaaggctct gagcaaatgt   1620

ggctcctggg ggttctttct tcctctgctg aaggaataaa ttgctccttg acattgtaga   1680

gcttctggca cttggagact tgtatgaaag atggctgtgc ctctgcctgt ctcccccacc   1740

gggctgggag ctctgcagag caggaaacat gactcgtata tgtctcaggt ccctgcaggg   1800

ccaagcacct agcctcgctc ttggcaggta ctcagcgaat gaatgctgta tatgttgggt   1860

gcaaagttcc ctacttcctg tgacttcagc tctgttttac aataaaatct tgaaaatgcc   1920

taaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa          1973


<210>  107
<211>  143
<212>  PRT
<213>  Homo sapiens

<400>  107


Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu 
1               5                   10                  15      


Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn 
            20                  25                  30          


Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala Leu Phe 
        35                  40                  45              


Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val Lys Ser Gly 
    50                  55                  60                  


Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp Leu Ser 
65                  70                  75                  80  


Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser 
                85                  90                  95      


Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp Phe Leu 
            100                 105                 110         


Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn Met Pro 
        115                 120                 125             


Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
    130                 135                 140             

<210>  108
<211>  5039
<212>  DNA
<213>  Homo sapiens

<400>  108
caagccgact gtgagccagg aagtgctctt ggggagccca ggccaagcca tccattcttg     60

ggtcctttgg agggtagata tggattccca gtttctccag cggccagtgc tccccctagt    120

ccacacagtg agaccgtgaa agcagatgct ccggggcact cctgggcagc ttttgctcag    180

tggatgatgg gtgactacag actccctgac cacccccagc ccatggaaat tctcaacctg    240

tacttgggag acagcctgga gccccaccca ggagagtgcc caagggaaac gtgcagccat    300

gaggatccac cggagccttt cgaggagcaa acctgggcca ctgaccctcc tgaacctacc    360

agacaaaatg ttcctccctg gggctccggt gtggagctca cacacctggg gagctgggtc    420

catcaggacg ggctggagcc ttgccaggag caaacccggg ccactgaccc tcctgaatct    480

accagacaag atgctcctcc ctggggctcc ggtgtggagc tcacacacct ggggagcccc    540

tctgcccaga gggagcacag gcagaacaca gcatcaccag ggtcaccagt gaacagccat    600

ctaccgggga gcccaaagca gaaccggagc acgtccacac aggtagtgtt ctgggcaggc    660

atcctgcagg cccagatgtg tgtcctagac ctggaggagg agctggagaa gacggaaggg    720

ctcaaggctg ggctgaaatg ctgtctcccc acgccccctg tggacctccc cggggacacg    780

ggcctgcact ccagcccacc tgagaatgaa gactcagggg aagacagcag tgagcctgag    840

ggagagggcc aggcatggct gagagaggga accccagact cttccccaca gtggggagct    900

gaggaggaga gcatgttctt cagcaacccc ctcttcctgg cgagtccttg ctcagagaac    960

agtgcttctg gagagtgctt ttcctggggg gcttcagact cccatgcagg tgtgaggact   1020

ggacctgaga gcccagcgac tctggagcct cccctcccag aagacacagt gctgtgggag   1080

ctggaaagtg agccagattt gggggacggc gctgctatca gtgggcattg tacccctcca   1140

ttccctgtgc ccatctataa accacactcc atctgctggg cctcagtggc tgccgctgag   1200

ggggctcctg cagcacctcc tggtcacggg gagagtgagg gagataggct tggtcctgct   1260

ccatctgcag caccgtgtgt ggacgaagca ttgacctggg aatcaggatg tgtcggatct   1320

gatcttggcc ctgctgcaca tcctgtgcaa ccttgggcct ctctcagccc tgagggctgg   1380

cagagaggag gtcctttttg gccccaggtg actcttaact cccaggacag agatgagagg   1440

gagggtggac acccccagga atctcttccc tgcaccttgg ccccctgccc ctggaggagc   1500

ccagcttctt ctccagagcc tagcagccca gaatctgaga gcagaggccc tggtcccagg   1560

cccagccctg catcgtccca ggagggcagc ccgcagcttc aacaccacag ctcaggcatt   1620

ttgcccaagt ggacactaga tgcttcacag tcttcactct tggagacgga tggggaacag   1680

ccaagttcct tgaagaaaaa ggaggcaggg gaggccccaa aaccaggcga ggaagtaaag   1740

agtgaaggaa cagccaggcc tgcagagact ggagacgtcc agcctgacat tcacctgact   1800

tctgcagaac atgagaatct gaggacaccg atgaactctt cttggcttcc tgggagccct   1860

atgccccaag cacagtcccc agaggaaggc cagagaccac cagctggaga caagctagct   1920

aatggcgtca ggaacaacaa ggtagcctgg aacttggcct cacgcctcta tcgcctggag   1980

ggcttccgga agtctgaagt ggctgcctac ctgcagaaga acaatgactt tagcagggct   2040

gtggctgagg agtacctgtc cttcttccag tttggaggcc agagtctgga ccgagccctc   2100

cggagcttcc tccaggcctt ggtgctcagt ggggagactc aggaacggga gcgaatcctc   2160

taccagttct ccagacgctt ccaccattgc aatccgggga tcttcccctc agtagattct   2220

gtacacacct tgacatgtgc aatcatgctg cttaacacgg acctgcatgg acagaacatt   2280

gggaagagca tgagctgcca ggaattcata accaacctga atgggctgag ggatggcggg   2340

aacttcccca aggagctgct gaaggccctc tactggtcta tccgcagcga gaagctcgag   2400

tgggccgtgg atgaagaaga cacagccaga cctgagaagg cccagccgtc cctgccagct   2460

ggcaagatga gcaagccctt ccttcagctg gctcaggatc ccacagtgcc cacctacaag   2520

cagggcatcc tggctcggaa aatgcatcaa gatgcagacg gcaagaagac gccatggggc   2580

aagcgtggct ggaagatgtt ccacacctta ctgcgaggga tggttctcta cttcctgaag   2640

cagggagaag accactgtct ggagggggag agcttggtgg ggcagatggt ggatgagccc   2700

gtgggggtgc accactcgct ggccaccccc gccacgcatt acaccaagaa gccgcacgtc   2760

ttccagctgc gcacggctga ctggcgcctc tacctcttcc aggcacccac tgccaaggag   2820

atgagctcct ggatcgcgcg catcaacttg gctgcggcca cgcactccgc gccgcccttc   2880

cccgccgctg tgggctccca gcgcagattc gtgcggccca tcctgcccgt gggccccgcc   2940

cagagctccc tggaggagca gcatcgatcc cacgagaact gcctggacgc tgccgcggac   3000

gacctgctgg atctacagag gaacctgccg gagcggcggg gccgtggccg cgagctggag   3060

gagcaccgcc tgcggaagga gtacctggag tacgagaaaa cccgctacga gacctacgtg   3120

cagctgctgg tggcccgcct gcactgcccc tctgatgctc tggacctgtg ggaggagcag   3180

ctggggaggg aagctggagg cactcgggag cccaagctca gcctgaagaa gtcccactcg   3240

agcccgtccc tgcaccagga tgaggctccc accacggcca aggtgaagcg caacatctca   3300

gagcgcagaa cctaccggaa gatcatccct aagcggaacc gcaatcagct gtgaagccag   3360

caccacctca gagacactgt tccctgctcc agggtagacc tgagatgaac ctccctggag   3420

gagacttatt tcaatgagtc caccatgacg gatgaggcac ctcctttccc tgctgaagga   3480

caaaccttgt ttccctgtgg ccctcattct tgtgctccct gaagctttcc taatattgct   3540

gtgctcccca ccacccccat ggcagtccct ccgcagcccc agtccctggc cacgcccaag   3600

ggaagaggga ggtgaggact tgactttcct cccagagctc agcccatgtc accctccagg   3660

ccccagaatc cagagtggcc tcatttccta gacttgctga gaactcagca cttgtttgag   3720

aaccagtgct tatgtggtgt gcccttggct tctgggggag agcttggggc agcagaggcc   3780

cctgggcagc ccagccaggg gagccacagc cccgaggatg gtcttgctct gggaattagg   3840

tgaccttcct ggggaggccc caggagagtg aatcagggac tcttgagaaa ttcctaacca   3900

gcctcctgtg acccagggag cagggtcgct aaggtcctgc ccactgaggg gacagccttc   3960

tgggcaggga cctcgggggg cttcaagggc tctgcacggc tgtggggccc tgtgcctttg   4020

tctccttgtg tctcctttcc cccgaagtag atgaaacagt ctcacatacc caactgctca   4080

tcaacagagc agagctgatg gcatgagtga gggctgggcg gggtggggcc tccagagctt   4140

tgcagggaac cctggaaccc taggaacaag gagcctttgt tccaacagag cagagaagga   4200

ggttctctat gttcagacca ctggagagga tagagaggta aaaggtggcg acagtttccc   4260

ttaggggtct gcctggcagg agccacagct caggagagtt gtgagggatg ggacggaggc   4320

tggcgaccag gcgaggccta ggccaggctc gggagacttt tctgtgctcc tttctacaca   4380

tgccttaaac cttccttcct gtggggtgcc tggacccctt ccccatctct ggcagctcag   4440

agggtctctg ctgctctccc ctgggaaatc ccctcatcct gccctctggc tgcctcccag   4500

ctgggcttgt tctctgaggg aggttccgga gactcatgga cttggggctc tgcctgtagg   4560

aaggaggctg ggccggaggg accagccacc attgtctctg ttcagccaag tgtgcaagta   4620

ggctgcccgc caagaggggg cctctgctac ccgctgctgc ctgccggctg acacactgcc   4680

tccccagcct tcctgctagg ccaccctcct cccttcccat gcttgtaacc agctctgggg   4740

cttgcacctc cacaaagtaa ggttggccct tggaggccat gtttgggtct ccggccaggg   4800

cctagggcta ggccatgcac ccaatgggtg cacaataaat aacaggtcaa caaagaggga   4860

ggtgtgtcag tgtgtgagga agggaggtca ggcagctagg accacctgca gtgtggcagg   4920

cttcatccct ctttgctcca agtgtgtatg tgtgtctgtg catgtgtgta gtgtctgtgt   4980

ctgtgtgttc atgcatatgc aggagtcaca cggtcatagg ccatcaaagc tggaggaga    5039


<210>  109
<211>  1056
<212>  PRT
<213>  Homo sapiens

<400>  109


Met Met Gly Asp Tyr Arg Leu Pro Asp His Pro Gln Pro Met Glu Ile 
1               5                   10                  15      


Leu Asn Leu Tyr Leu Gly Asp Ser Leu Glu Pro His Pro Gly Glu Cys 
            20                  25                  30          


Pro Arg Glu Thr Cys Ser His Glu Asp Pro Pro Glu Pro Phe Glu Glu 
        35                  40                  45              


Gln Thr Trp Ala Thr Asp Pro Pro Glu Pro Thr Arg Gln Asn Val Pro 
    50                  55                  60                  


Pro Trp Gly Ser Gly Val Glu Leu Thr His Leu Gly Ser Trp Val His 
65                  70                  75                  80  


Gln Asp Gly Leu Glu Pro Cys Gln Glu Gln Thr Arg Ala Thr Asp Pro 
                85                  90                  95      


Pro Glu Ser Thr Arg Gln Asp Ala Pro Pro Trp Gly Ser Gly Val Glu 
            100                 105                 110         


Leu Thr His Leu Gly Ser Pro Ser Ala Gln Arg Glu His Arg Gln Asn 
        115                 120                 125             


Thr Ala Ser Pro Gly Ser Pro Val Asn Ser His Leu Pro Gly Ser Pro 
    130                 135                 140                 


Lys Gln Asn Arg Ser Thr Ser Thr Gln Val Val Phe Trp Ala Gly Ile 
145                 150                 155                 160 


Leu Gln Ala Gln Met Cys Val Leu Asp Leu Glu Glu Glu Leu Glu Lys 
                165                 170                 175     


Thr Glu Gly Leu Lys Ala Gly Leu Lys Cys Cys Leu Pro Thr Pro Pro 
            180                 185                 190         


Val Asp Leu Pro Gly Asp Thr Gly Leu His Ser Ser Pro Pro Glu Asn 
        195                 200                 205             


Glu Asp Ser Gly Glu Asp Ser Ser Glu Pro Glu Gly Glu Gly Gln Ala 
    210                 215                 220                 


Trp Leu Arg Glu Gly Thr Pro Asp Ser Ser Pro Gln Trp Gly Ala Glu 
225                 230                 235                 240 


Glu Glu Ser Met Phe Phe Ser Asn Pro Leu Phe Leu Ala Ser Pro Cys 
                245                 250                 255     


Ser Glu Asn Ser Ala Ser Gly Glu Cys Phe Ser Trp Gly Ala Ser Asp 
            260                 265                 270         


Ser His Ala Gly Val Arg Thr Gly Pro Glu Ser Pro Ala Thr Leu Glu 
        275                 280                 285             


Pro Pro Leu Pro Glu Asp Thr Val Leu Trp Glu Leu Glu Ser Glu Pro 
    290                 295                 300                 


Asp Leu Gly Asp Gly Ala Ala Ile Ser Gly His Cys Thr Pro Pro Phe 
305                 310                 315                 320 


Pro Val Pro Ile Tyr Lys Pro His Ser Ile Cys Trp Ala Ser Val Ala 
                325                 330                 335     


Ala Ala Glu Gly Ala Pro Ala Ala Pro Pro Gly His Gly Glu Ser Glu 
            340                 345                 350         


Gly Asp Arg Leu Gly Pro Ala Pro Ser Ala Ala Pro Cys Val Asp Glu 
        355                 360                 365             


Ala Leu Thr Trp Glu Ser Gly Cys Val Gly Ser Asp Leu Gly Pro Ala 
    370                 375                 380                 


Ala His Pro Val Gln Pro Trp Ala Ser Leu Ser Pro Glu Gly Trp Gln 
385                 390                 395                 400 


Arg Gly Gly Pro Phe Trp Pro Gln Val Thr Leu Asn Ser Gln Asp Arg 
                405                 410                 415     


Asp Glu Arg Glu Gly Gly His Pro Gln Glu Ser Leu Pro Cys Thr Leu 
            420                 425                 430         


Ala Pro Cys Pro Trp Arg Ser Pro Ala Ser Ser Pro Glu Pro Ser Ser 
        435                 440                 445             


Pro Glu Ser Glu Ser Arg Gly Pro Gly Pro Arg Pro Ser Pro Ala Ser 
    450                 455                 460                 


Ser Gln Glu Gly Ser Pro Gln Leu Gln His His Ser Ser Gly Ile Leu 
465                 470                 475                 480 


Pro Lys Trp Thr Leu Asp Ala Ser Gln Ser Ser Leu Leu Glu Thr Asp 
                485                 490                 495     


Gly Glu Gln Pro Ser Ser Leu Lys Lys Lys Glu Ala Gly Glu Ala Pro 
            500                 505                 510         


Lys Pro Gly Glu Glu Val Lys Ser Glu Gly Thr Ala Arg Pro Ala Glu 
        515                 520                 525             


Thr Gly Asp Val Gln Pro Asp Ile His Leu Thr Ser Ala Glu His Glu 
    530                 535                 540                 


Asn Leu Arg Thr Pro Met Asn Ser Ser Trp Leu Pro Gly Ser Pro Met 
545                 550                 555                 560 


Pro Gln Ala Gln Ser Pro Glu Glu Gly Gln Arg Pro Pro Ala Gly Asp 
                565                 570                 575     


Lys Leu Ala Asn Gly Val Arg Asn Asn Lys Val Ala Trp Asn Leu Ala 
            580                 585                 590         


Ser Arg Leu Tyr Arg Leu Glu Gly Phe Arg Lys Ser Glu Val Ala Ala 
        595                 600                 605             


Tyr Leu Gln Lys Asn Asn Asp Phe Ser Arg Ala Val Ala Glu Glu Tyr 
    610                 615                 620                 


Leu Ser Phe Phe Gln Phe Gly Gly Gln Ser Leu Asp Arg Ala Leu Arg 
625                 630                 635                 640 


Ser Phe Leu Gln Ala Leu Val Leu Ser Gly Glu Thr Gln Glu Arg Glu 
                645                 650                 655     


Arg Ile Leu Tyr Gln Phe Ser Arg Arg Phe His His Cys Asn Pro Gly 
            660                 665                 670         


Ile Phe Pro Ser Val Asp Ser Val His Thr Leu Thr Cys Ala Ile Met 
        675                 680                 685             


Leu Leu Asn Thr Asp Leu His Gly Gln Asn Ile Gly Lys Ser Met Ser 
    690                 695                 700                 


Cys Gln Glu Phe Ile Thr Asn Leu Asn Gly Leu Arg Asp Gly Gly Asn 
705                 710                 715                 720 


Phe Pro Lys Glu Leu Leu Lys Ala Leu Tyr Trp Ser Ile Arg Ser Glu 
                725                 730                 735     


Lys Leu Glu Trp Ala Val Asp Glu Glu Asp Thr Ala Arg Pro Glu Lys 
            740                 745                 750         


Ala Gln Pro Ser Leu Pro Ala Gly Lys Met Ser Lys Pro Phe Leu Gln 
        755                 760                 765             


Leu Ala Gln Asp Pro Thr Val Pro Thr Tyr Lys Gln Gly Ile Leu Ala 
    770                 775                 780                 


Arg Lys Met His Gln Asp Ala Asp Gly Lys Lys Thr Pro Trp Gly Lys 
785                 790                 795                 800 


Arg Gly Trp Lys Met Phe His Thr Leu Leu Arg Gly Met Val Leu Tyr 
                805                 810                 815     


Phe Leu Lys Gln Gly Glu Asp His Cys Leu Glu Gly Glu Ser Leu Val 
            820                 825                 830         


Gly Gln Met Val Asp Glu Pro Val Gly Val His His Ser Leu Ala Thr 
        835                 840                 845             


Pro Ala Thr His Tyr Thr Lys Lys Pro His Val Phe Gln Leu Arg Thr 
    850                 855                 860                 


Ala Asp Trp Arg Leu Tyr Leu Phe Gln Ala Pro Thr Ala Lys Glu Met 
865                 870                 875                 880 


Ser Ser Trp Ile Ala Arg Ile Asn Leu Ala Ala Ala Thr His Ser Ala 
                885                 890                 895     


Pro Pro Phe Pro Ala Ala Val Gly Ser Gln Arg Arg Phe Val Arg Pro 
            900                 905                 910         


Ile Leu Pro Val Gly Pro Ala Gln Ser Ser Leu Glu Glu Gln His Arg 
        915                 920                 925             


Ser His Glu Asn Cys Leu Asp Ala Ala Ala Asp Asp Leu Leu Asp Leu 
    930                 935                 940                 


Gln Arg Asn Leu Pro Glu Arg Arg Gly Arg Gly Arg Glu Leu Glu Glu 
945                 950                 955                 960 


His Arg Leu Arg Lys Glu Tyr Leu Glu Tyr Glu Lys Thr Arg Tyr Glu 
                965                 970                 975     


Thr Tyr Val Gln Leu Leu Val Ala Arg Leu His Cys Pro Ser Asp Ala 
            980                 985                 990         


Leu Asp Leu Trp Glu Glu Gln Leu  Gly Arg Glu Ala Gly  Gly Thr Arg 
        995                 1000                 1005             


Glu Pro  Lys Leu Ser Leu Lys  Lys Ser His Ser Ser  Pro Ser Leu 
    1010                 1015                 1020             


His Gln  Asp Glu Ala Pro Thr  Thr Ala Lys Val Lys  Arg Asn Ile 
    1025                 1030                 1035             


Ser Glu  Arg Arg Thr Tyr Arg  Lys Ile Ile Pro Lys  Arg Asn Arg 
    1040                 1045                 1050             


Asn Gln  Leu 
    1055     

<210>  110
<211>  6926
<212>  DNA
<213>  Homo sapiens

<400>  110
atttgagcat cagttgaggg agaggacgct tcatttcctt tttggttggg aatgtgccgt     60

gaacatcctc tgctggagct tggggcctgg agcagactgg ggctgcagat ttagacgtag    120

acgtttccga ggacgcgaga ctgcagagct ttgtaggcag ccaatcccag agaagcagac    180

gggatggcta gttcagcccg ggagcacctg ctttttgtga ggcgtcgaaa tccccagatg    240

cggtacacat tgagcccaga gaacctccag agccttgccg cccagagctc catgccagag    300

aacatgaccc tgcagcgggc caacagcgac accgacctgg tgacttctga gagccgctcc    360

agcttaactg ccagcatgta cgagtacacg ctggggcaag cccagaacct cattatcttc    420

tgggacatta aagaggaggt ggaccccagt gattggattg gactttatca tatagatgag    480

aattctccag ccaacttctg ggattctaag aacaggggtg tgactggaac acaaaaaggg    540

caaattgtat ggagaattga gcctgggccc tatttcatgg aaccggagat aaaaatctgt    600

tttaaatatt accacggcat tagtggagcc ctgcgagcca cgaccccctg catcaccgtg    660

aagaacccag ctgtgatgat gggggcagaa ggcatggagg gaggtgcttc aggaaacctg    720

cattctcgaa aacttgttag ctttacattg tcagatctta gggcagttgg gctaaagaaa    780

gggatgttct tcaatcctga cccttatctt aagatgtcaa ttcagccagg aaagaagagc    840

agtttcccca cctgtgccca ccacgggcag gagagacggt ctactatcat cagtaacacc    900

accaatccaa tttggcaccg agagaaatat tccttttttg cacttcttac tgatgtctta    960

gaaattgaaa ttaaagacaa atttgccaag agccgtccca tcatcaagcg ttttctgggg   1020

aaactaacca ttccagtcca gaggctgctg gagcgacaag ccatcggtga tcaaatgctc   1080

agctacaacc ttggcagaag gctcccagct gaccacgtga gtgggtacct ccagtttaaa   1140

gtggaggtta cgtcttctgt tcatgaagat gcctctccag aagctgttgg cacaatactt   1200

ggagtcaatt ctgtgaatgg agacttaggt agcccttccg atgacgagga catgccaggg   1260

agccatcacg acagccaggt gtgctctaat gggccagttt ctgaggacag tgctgccgat   1320

ggaaccccca agcattcatt caggactagc tccactctgg aaatagacac agaggaatta   1380

acctctacgt cttcaaggac ctcacctccc agaggacgtc aggattcact caatgattac   1440

ttagatgcta tcgaacacaa tggccactcc aggccaggga cagcgacctg ctctgagagg   1500

tccatgggtg cctctccgaa actgaggagt agttttccca ctgacacaag actcaatgcc   1560

atgcttcata ttgattcaga tgaagaagat cacgagttcc agcaagacct gggttaccca   1620

tcttccttgg aggaggaggg aggcctgatc atgtttagca gggcatccag agctgatgat   1680

ggaagcctga catctcagac aaagctggag gacaaccctg ttgagaatga ggaagcctcc   1740

acacacgaag ctgcttcctt tgaggataag ccagaaaatc ttccagagct tgcagagagc   1800

tccttacctg caggcccagc cccagaggaa ggtgaaggcg gcccagagcc tcaacccagt   1860

gctgaccagg gcagtgctga actgtgtggc tctcaagagg tagatcagcc cacaagtggc   1920

gcagacacag ggacttccga tgcatcagga ggaagccgaa gagccgtcag tgagaccgag   1980

tctctcgatc agggctctga gccttcccag gtgtcctctg aaacagaacc cagtgatcct   2040

gccaggacag agagtgtgag cgaagccagc accaggcctg agggagagag tgacctggaa   2100

tgcgctgaca gctcctgcaa tgagagtgtg accacgcagc tgtcctctgt ggacacacgg   2160

tgctcctctc ttgagagcgc acggtttcct gaaaccccag ccttttcttc tcaggaggag   2220

gaagacggag cctgtgcagc agagcccacc agcagtggcc ctgccgaagg gtcgcaggaa   2280

tccgtgtgca ctgctggttc tttacctgtg gtacaggtgc ccagtgggga ggatgaaggg   2340

ccaggggcag aatcggccac tgtacctgac caggaggagc tgggggaggt ctggcagcgg   2400

agggggagcc tggagggagc tgcagctgct gccgagagcc caccgcaaga agaaggcagt   2460

gctggggagg cccaaggcac ctgtgaaggg gcaactgccc aggaggaggg cgctactgga   2520

ggttctcaag ccaacggcca ccagccactg cgatcactac cttcagtgcg ccaggatgtt   2580

agccggtacc agagggtgga cgaggctctc ccaccaaact gggaggcacg cattgacagc   2640

cacggcagga tcttctacgt ggatcacgta aacagaacca cgacgtggca gcgaccgaca   2700

gctcccccag ccccgcaggt gctgcagaga tctaactcca tacagcaaat ggagcagctg   2760

aaccggcgat atcagagtat ccgcagaacc atgaccaatg agaggcctga ggaaaatacc   2820

aatgctattg atggggcagg ggaggaagct gactttcacc aagccagtgc agatttccga   2880

cgggagaaca tcctgcctca ctctacctcc agatccagga tcacgttgct gttacagtct   2940

ccccccgtga agttcctcat cagcccagag ttcttcaccg tgctgcattc taaccctagt   3000

gcctaccgca tgtttacaaa caacacgtgt ttgaagcaca tgatcaccaa agtccggagg   3060

gacacccacc actttgaacg ctaccagcat aaccgcgacc ttgtgggatt cctcaacatg   3120

ttcgcgaaca aacagctaga gctgccgcgg ggatgggaaa tgaaacatga tcaccagggc   3180

aaggcattct ttgtggacca caactcccgc accaccactt tcattgatcc ccggctccca   3240

cttcagagca gtagacccac aagtgcgctg gttcatcggc aacacctgac aaggcaacgc   3300

agccacagtg cgggtgaggt aggagaagat tctcgacatg caggaccacc agttcttccc   3360

aggccatcca gtacattcaa tacagtcagt aggccacagt accaggacat ggttccagtg   3420

gcttacaatg acaagattgt tgcatttcta cgtcaaccca atatctttga aattctacag   3480

gagcgtcaac ctgatcttac caggaatcac tcactcaggg agaagatcca atttatccga   3540

actgaaggga ctccaggatt ggtgcgcctt tcaagcgatg cagaccttgt tatgttgctg   3600

agcttatttg aagaagagat aatgtcatat gtgcctccac atgccttact ccaccccagc   3660

tactgtcagt ccccacgtgg ctctcccgtg tcatctcctc agaactcgcc aggtacccag   3720

cgtgccaatg cccgggctcc agccccttac aagcgggatt tcgaagccaa actgaggaac   3780

ttttacagga agttagagac taaaggatat ggacaaggcc cagggaagtt aaagttaatt   3840

atccgaagag atcacttact agaagatgct tttaatcaga ttatgggcta ctccagaaaa   3900

gacctgcaga gaaataagct atatgtcacc ttcgttgggg aggaagggct ggattacagt   3960

gggccttcta gagagttttt cttcctggta tccagagaac tctttaaccc atattatggc   4020

ttatttgaat attcagccaa tgacacatac acagtacaaa taagtcctat gtctgctttt   4080

gtagacaatc accatgaatg gttccgattc agtggtagga tccttggtct tgcactaata   4140

caccagtatt tgttggatgc cttcttcaca cggccctttt ataaggctct tctcagaatt   4200

ctatgtgacc tgagtgacct agaatacctt gatgaagagt tccatcagag cctgcagtgg   4260

atgaaagaca atgatatcca tgacatccta gacctcacgt tcactgtgaa cgaagaagta   4320

tttgggcaga taactgaacg agaattaaag ccagggggtg ccaatatccc agttacagag   4380

aagaacaaga aggagtacat cgagaggatg gtgaagtgga ggattgagag gggtgttgta   4440

cagcaaacag agagcttagt gcgtggcttc tatgaggtgg tggatgccag gctggtatct   4500

gtttttgatg caagagaact ggaattggtc atcgcaggca cagctgaaat agacctaagt   4560

gattggagaa acaacacaga atatagagga ggataccatg acaatcatat tgtaattcgg   4620

tggttctggg ctgcagtgga aagattcaac aatgaacaac gactaaggtt gttacagttt   4680

gttacaggca catccagcat tccctatgaa ggatttgctt cactccgagg gagtaacggc   4740

ccaagaagat tctgtgtgga gaaatggggg aaaatcactg ctcttcccag agcgcataca   4800

tgttttaacc gtctggatct gcctccctac ccatcctttt ccatgcttta tgaaaaactg   4860

ttgacagcag ttgaagaaac cagtactttt ggacttgagt gacctggaag ctgaatgccc   4920

atctctgtgg acaggcagtt tcagaagctg ccttctagaa gaatgattga acattggaag   4980

tttcaagagg atgcttcctt taggataaag ctacgtgctg ttgttttcca ggaacaagtg   5040

ctctgtcaca tttggggact ggagatgagt cctcttggaa ggatttgggt gagcttgatg   5100

cccagggaac aacccaaccg tctttcaatc aacagttctt gactgccaaa ctttttccat   5160

ttgttatgtt ccaagacaaa gatgaaccca tacatgatca gctccacggt aatttttagg   5220

gactcaggag aatcttgaaa cttacccttg aacgtggttc aagccaaact ggcagcattt   5280

ggcccaatct ccaaattaga gcaagttaaa taatataata aaagtaaata tatttcctga   5340

aagtacattc atttaagccc taagttataa cagaatattc atttcttgct tatgagtgcc   5400

tgcatggtgt gcaccatagg tttccgcttt catgggacat gagtgaaaat gaaaccaagt   5460

caatatgagg tacctttaca gatttgcaat aagatggtct gtgacaatgt atatgcaagt   5520

ggtatgtgtg taattatggc taaagacaaa ccattattca gtgaattact aatgacagat   5580

tttatgcttt ataatgcatg aaaacaattt taaaataact agcaattaat cacagcatat   5640

caggaaaaag tacacagtga gttctgttta ttttttgtag gctcattatg tttatgttct   5700

ttaagatgta tataagaacc tacctatcat gctgtatgta tcactcattc cattttcatg   5760

ttccatgcat actcgggcat catgctaata tgtatccttt taagcactct caaggaaaca   5820

aaagggcctt ttatttttat aaaggtaaaa aaaattcccc aaatattttg cactgaatgt   5880

accaaaggtg aagggacatt acaatatgac taacagcaac tccatcactt gagaagtata   5940

atagaaaata gcttctaaat caaacttcct tcacagtgcc gtgtctacca ctacaaggac   6000

tgtgcatcta agtaataatt ttttaagatt cactatatgt gatagtatga tatgcattta   6060

tttaaaatgc attagactct cttccatcca tcaaatactt tacaggatgg catttaatac   6120

agatatttcg tatttccccc actgcttttt atttgtacag catcattaaa cactaagctc   6180

agttaaggag ccatcagcaa cactgaagag atcagtagta agaattccat tttccctcat   6240

cagtgaagac accacaaatt gaaactcaga actatatttc taagcctgca ttttcactga   6300

tgcataattt tcttattaat attaagagac agtttttcta tggcatctcc aaaactgcat   6360

gacatcacta gtcttacttc tgcttaattt tatgagaagg tattcttcat tttaattgct   6420

tttgggatta ctccacatct ttgtttattt cttgactaat cagattttca atagagtgaa   6480

gttaaattgg gggtcataaa agcattggat tgacatatgg tttgccagcc tatgggttta   6540

caggcattgc ccaaacattt ctttgagatc tatatttata agcagccatg gaattcctat   6600

tatgggatgt tggcaatctt acattttata gaggtcatat gcatagtttt cataggtgtt   6660

ttgtaagaac tgattgctct cctgtgagtt aagctatgtt tactactggg accctcaaga   6720

ggaataccac ttatgttaca ctcctgcact aaaggcatgt actgcagtgt gaagaaatgt   6780

tctgaaaaag ggttatagaa atctggaaat aagaaaggaa gagctctctg tattctataa   6840

ttggaagaga aaaaaagaaa aacttttaac tggaaatgtt agtttgtact tattgatcat   6900

gaatacaagt atatatttaa ttttgc                                        6926


<210>  111
<211>  1572
<212>  PRT
<213>  Homo sapiens

<400>  111


Met Ala Ser Ser Ala Arg Glu His Leu Leu Phe Val Arg Arg Arg Asn 
1               5                   10                  15      


Pro Gln Met Arg Tyr Thr Leu Ser Pro Glu Asn Leu Gln Ser Leu Ala 
            20                  25                  30          


Ala Gln Ser Ser Met Pro Glu Asn Met Thr Leu Gln Arg Ala Asn Ser 
        35                  40                  45              


Asp Thr Asp Leu Val Thr Ser Glu Ser Arg Ser Ser Leu Thr Ala Ser 
    50                  55                  60                  


Met Tyr Glu Tyr Thr Leu Gly Gln Ala Gln Asn Leu Ile Ile Phe Trp 
65                  70                  75                  80  


Asp Ile Lys Glu Glu Val Asp Pro Ser Asp Trp Ile Gly Leu Tyr His 
                85                  90                  95      


Ile Asp Glu Asn Ser Pro Ala Asn Phe Trp Asp Ser Lys Asn Arg Gly 
            100                 105                 110         


Val Thr Gly Thr Gln Lys Gly Gln Ile Val Trp Arg Ile Glu Pro Gly 
        115                 120                 125             


Pro Tyr Phe Met Glu Pro Glu Ile Lys Ile Cys Phe Lys Tyr Tyr His 
    130                 135                 140                 


Gly Ile Ser Gly Ala Leu Arg Ala Thr Thr Pro Cys Ile Thr Val Lys 
145                 150                 155                 160 


Asn Pro Ala Val Met Met Gly Ala Glu Gly Met Glu Gly Gly Ala Ser 
                165                 170                 175     


Gly Asn Leu His Ser Arg Lys Leu Val Ser Phe Thr Leu Ser Asp Leu 
            180                 185                 190         


Arg Ala Val Gly Leu Lys Lys Gly Met Phe Phe Asn Pro Asp Pro Tyr 
        195                 200                 205             


Leu Lys Met Ser Ile Gln Pro Gly Lys Lys Ser Ser Phe Pro Thr Cys 
    210                 215                 220                 


Ala His His Gly Gln Glu Arg Arg Ser Thr Ile Ile Ser Asn Thr Thr 
225                 230                 235                 240 


Asn Pro Ile Trp His Arg Glu Lys Tyr Ser Phe Phe Ala Leu Leu Thr 
                245                 250                 255     


Asp Val Leu Glu Ile Glu Ile Lys Asp Lys Phe Ala Lys Ser Arg Pro 
            260                 265                 270         


Ile Ile Lys Arg Phe Leu Gly Lys Leu Thr Ile Pro Val Gln Arg Leu 
        275                 280                 285             


Leu Glu Arg Gln Ala Ile Gly Asp Gln Met Leu Ser Tyr Asn Leu Gly 
    290                 295                 300                 


Arg Arg Leu Pro Ala Asp His Val Ser Gly Tyr Leu Gln Phe Lys Val 
305                 310                 315                 320 


Glu Val Thr Ser Ser Val His Glu Asp Ala Ser Pro Glu Ala Val Gly 
                325                 330                 335     


Thr Ile Leu Gly Val Asn Ser Val Asn Gly Asp Leu Gly Ser Pro Ser 
            340                 345                 350         


Asp Asp Glu Asp Met Pro Gly Ser His His Asp Ser Gln Val Cys Ser 
        355                 360                 365             


Asn Gly Pro Val Ser Glu Asp Ser Ala Ala Asp Gly Thr Pro Lys His 
    370                 375                 380                 


Ser Phe Arg Thr Ser Ser Thr Leu Glu Ile Asp Thr Glu Glu Leu Thr 
385                 390                 395                 400 


Ser Thr Ser Ser Arg Thr Ser Pro Pro Arg Gly Arg Gln Asp Ser Leu 
                405                 410                 415     


Asn Asp Tyr Leu Asp Ala Ile Glu His Asn Gly His Ser Arg Pro Gly 
            420                 425                 430         


Thr Ala Thr Cys Ser Glu Arg Ser Met Gly Ala Ser Pro Lys Leu Arg 
        435                 440                 445             


Ser Ser Phe Pro Thr Asp Thr Arg Leu Asn Ala Met Leu His Ile Asp 
    450                 455                 460                 


Ser Asp Glu Glu Asp His Glu Phe Gln Gln Asp Leu Gly Tyr Pro Ser 
465                 470                 475                 480 


Ser Leu Glu Glu Glu Gly Gly Leu Ile Met Phe Ser Arg Ala Ser Arg 
                485                 490                 495     


Ala Asp Asp Gly Ser Leu Thr Ser Gln Thr Lys Leu Glu Asp Asn Pro 
            500                 505                 510         


Val Glu Asn Glu Glu Ala Ser Thr His Glu Ala Ala Ser Phe Glu Asp 
        515                 520                 525             


Lys Pro Glu Asn Leu Pro Glu Leu Ala Glu Ser Ser Leu Pro Ala Gly 
    530                 535                 540                 


Pro Ala Pro Glu Glu Gly Glu Gly Gly Pro Glu Pro Gln Pro Ser Ala 
545                 550                 555                 560 


Asp Gln Gly Ser Ala Glu Leu Cys Gly Ser Gln Glu Val Asp Gln Pro 
                565                 570                 575     


Thr Ser Gly Ala Asp Thr Gly Thr Ser Asp Ala Ser Gly Gly Ser Arg 
            580                 585                 590         


Arg Ala Val Ser Glu Thr Glu Ser Leu Asp Gln Gly Ser Glu Pro Ser 
        595                 600                 605             


Gln Val Ser Ser Glu Thr Glu Pro Ser Asp Pro Ala Arg Thr Glu Ser 
    610                 615                 620                 


Val Ser Glu Ala Ser Thr Arg Pro Glu Gly Glu Ser Asp Leu Glu Cys 
625                 630                 635                 640 


Ala Asp Ser Ser Cys Asn Glu Ser Val Thr Thr Gln Leu Ser Ser Val 
                645                 650                 655     


Asp Thr Arg Cys Ser Ser Leu Glu Ser Ala Arg Phe Pro Glu Thr Pro 
            660                 665                 670         


Ala Phe Ser Ser Gln Glu Glu Glu Asp Gly Ala Cys Ala Ala Glu Pro 
        675                 680                 685             


Thr Ser Ser Gly Pro Ala Glu Gly Ser Gln Glu Ser Val Cys Thr Ala 
    690                 695                 700                 


Gly Ser Leu Pro Val Val Gln Val Pro Ser Gly Glu Asp Glu Gly Pro 
705                 710                 715                 720 


Gly Ala Glu Ser Ala Thr Val Pro Asp Gln Glu Glu Leu Gly Glu Val 
                725                 730                 735     


Trp Gln Arg Arg Gly Ser Leu Glu Gly Ala Ala Ala Ala Ala Glu Ser 
            740                 745                 750         


Pro Pro Gln Glu Glu Gly Ser Ala Gly Glu Ala Gln Gly Thr Cys Glu 
        755                 760                 765             


Gly Ala Thr Ala Gln Glu Glu Gly Ala Thr Gly Gly Ser Gln Ala Asn 
    770                 775                 780                 


Gly His Gln Pro Leu Arg Ser Leu Pro Ser Val Arg Gln Asp Val Ser 
785                 790                 795                 800 


Arg Tyr Gln Arg Val Asp Glu Ala Leu Pro Pro Asn Trp Glu Ala Arg 
                805                 810                 815     


Ile Asp Ser His Gly Arg Ile Phe Tyr Val Asp His Val Asn Arg Thr 
            820                 825                 830         


Thr Thr Trp Gln Arg Pro Thr Ala Pro Pro Ala Pro Gln Val Leu Gln 
        835                 840                 845             


Arg Ser Asn Ser Ile Gln Gln Met Glu Gln Leu Asn Arg Arg Tyr Gln 
    850                 855                 860                 


Ser Ile Arg Arg Thr Met Thr Asn Glu Arg Pro Glu Glu Asn Thr Asn 
865                 870                 875                 880 


Ala Ile Asp Gly Ala Gly Glu Glu Ala Asp Phe His Gln Ala Ser Ala 
                885                 890                 895     


Asp Phe Arg Arg Glu Asn Ile Leu Pro His Ser Thr Ser Arg Ser Arg 
            900                 905                 910         


Ile Thr Leu Leu Leu Gln Ser Pro Pro Val Lys Phe Leu Ile Ser Pro 
        915                 920                 925             


Glu Phe Phe Thr Val Leu His Ser Asn Pro Ser Ala Tyr Arg Met Phe 
    930                 935                 940                 


Thr Asn Asn Thr Cys Leu Lys His Met Ile Thr Lys Val Arg Arg Asp 
945                 950                 955                 960 


Thr His His Phe Glu Arg Tyr Gln His Asn Arg Asp Leu Val Gly Phe 
                965                 970                 975     


Leu Asn Met Phe Ala Asn Lys Gln Leu Glu Leu Pro Arg Gly Trp Glu 
            980                 985                 990         


Met Lys His Asp His Gln Gly Lys  Ala Phe Phe Val Asp  His Asn Ser 
        995                 1000                 1005             


Arg Thr  Thr Thr Phe Ile Asp  Pro Arg Leu Pro Leu  Gln Ser Ser 
    1010                 1015                 1020             


Arg Pro  Thr Ser Ala Leu Val  His Arg Gln His Leu  Thr Arg Gln 
    1025                 1030                 1035             


Arg Ser  His Ser Ala Gly Glu  Val Gly Glu Asp Ser  Arg His Ala 
    1040                 1045                 1050             


Gly Pro  Pro Val Leu Pro Arg  Pro Ser Ser Thr Phe  Asn Thr Val 
    1055                 1060                 1065             


Ser Arg  Pro Gln Tyr Gln Asp  Met Val Pro Val Ala  Tyr Asn Asp 
    1070                 1075                 1080             


Lys Ile  Val Ala Phe Leu Arg  Gln Pro Asn Ile Phe  Glu Ile Leu 
    1085                 1090                 1095             


Gln Glu  Arg Gln Pro Asp Leu  Thr Arg Asn His Ser  Leu Arg Glu 
    1100                 1105                 1110             


Lys Ile  Gln Phe Ile Arg Thr  Glu Gly Thr Pro Gly  Leu Val Arg 
    1115                 1120                 1125             


Leu Ser  Ser Asp Ala Asp Leu  Val Met Leu Leu Ser  Leu Phe Glu 
    1130                 1135                 1140             


Glu Glu  Ile Met Ser Tyr Val  Pro Pro His Ala Leu  Leu His Pro 
    1145                 1150                 1155             


Ser Tyr  Cys Gln Ser Pro Arg  Gly Ser Pro Val Ser  Ser Pro Gln 
    1160                 1165                 1170             


Asn Ser  Pro Gly Thr Gln Arg  Ala Asn Ala Arg Ala  Pro Ala Pro 
    1175                 1180                 1185             


Tyr Lys  Arg Asp Phe Glu Ala  Lys Leu Arg Asn Phe  Tyr Arg Lys 
    1190                 1195                 1200             


Leu Glu  Thr Lys Gly Tyr Gly  Gln Gly Pro Gly Lys  Leu Lys Leu 
    1205                 1210                 1215             


Ile Ile  Arg Arg Asp His Leu  Leu Glu Asp Ala Phe  Asn Gln Ile 
    1220                 1225                 1230             


Met Gly  Tyr Ser Arg Lys Asp  Leu Gln Arg Asn Lys  Leu Tyr Val 
    1235                 1240                 1245             


Thr Phe  Val Gly Glu Glu Gly  Leu Asp Tyr Ser Gly  Pro Ser Arg 
    1250                 1255                 1260             


Glu Phe  Phe Phe Leu Val Ser  Arg Glu Leu Phe Asn  Pro Tyr Tyr 
    1265                 1270                 1275             


Gly Leu  Phe Glu Tyr Ser Ala  Asn Asp Thr Tyr Thr  Val Gln Ile 
    1280                 1285                 1290             


Ser Pro  Met Ser Ala Phe Val  Asp Asn His His Glu  Trp Phe Arg 
    1295                 1300                 1305             


Phe Ser  Gly Arg Ile Leu Gly  Leu Ala Leu Ile His  Gln Tyr Leu 
    1310                 1315                 1320             


Leu Asp  Ala Phe Phe Thr Arg  Pro Phe Tyr Lys Ala  Leu Leu Arg 
    1325                 1330                 1335             


Ile Leu  Cys Asp Leu Ser Asp  Leu Glu Tyr Leu Asp  Glu Glu Phe 
    1340                 1345                 1350             


His Gln  Ser Leu Gln Trp Met  Lys Asp Asn Asp Ile  His Asp Ile 
    1355                 1360                 1365             


Leu Asp  Leu Thr Phe Thr Val  Asn Glu Glu Val Phe  Gly Gln Ile 
    1370                 1375                 1380             


Thr Glu  Arg Glu Leu Lys Pro  Gly Gly Ala Asn Ile  Pro Val Thr 
    1385                 1390                 1395             


Glu Lys  Asn Lys Lys Glu Tyr  Ile Glu Arg Met Val  Lys Trp Arg 
    1400                 1405                 1410             


Ile Glu  Arg Gly Val Val Gln  Gln Thr Glu Ser Leu  Val Arg Gly 
    1415                 1420                 1425             


Phe Tyr  Glu Val Val Asp Ala  Arg Leu Val Ser Val  Phe Asp Ala 
    1430                 1435                 1440             


Arg Glu  Leu Glu Leu Val Ile  Ala Gly Thr Ala Glu  Ile Asp Leu 
    1445                 1450                 1455             


Ser Asp  Trp Arg Asn Asn Thr  Glu Tyr Arg Gly Gly  Tyr His Asp 
    1460                 1465                 1470             


Asn His  Ile Val Ile Arg Trp  Phe Trp Ala Ala Val  Glu Arg Phe 
    1475                 1480                 1485             


Asn Asn  Glu Gln Arg Leu Arg  Leu Leu Gln Phe Val  Thr Gly Thr 
    1490                 1495                 1500             


Ser Ser  Ile Pro Tyr Glu Gly  Phe Ala Ser Leu Arg  Gly Ser Asn 
    1505                 1510                 1515             


Gly Pro  Arg Arg Phe Cys Val  Glu Lys Trp Gly Lys  Ile Thr Ala 
    1520                 1525                 1530             


Leu Pro  Arg Ala His Thr Cys  Phe Asn Arg Leu Asp  Leu Pro Pro 
    1535                 1540                 1545             


Tyr Pro  Ser Phe Ser Met Leu  Tyr Glu Lys Leu Leu  Thr Ala Val 
    1550                 1555                 1560             


Glu Glu  Thr Ser Thr Phe Gly  Leu Glu 
    1565                 1570         

<210>  112
<211>  3618
<212>  DNA
<213>  Homo sapiens

<400>  112
gcggccgccc ctccccgatt cccgccacct gccgcctggc caggtggaag gggcgctgcc     60

gcgagcctcc gggcctcagg gtgttccggg gagcggcgcc ccgggtctct gggcccaccc    120

gccccgggcg tcctccgaga gtgggggctg cgcccgcggg gtcagacacc tgttcggccc    180

ggcccggcgt ggtcgccggg ggccaggatg aaagtgaccg tgtgcttcgg caggacgggc    240

atcgtggtgc cctgcaagga gggccagctg cgcgtcggcg agctcaccca gcaggcgctg    300

cagcggtacc tgaagacccg ggagaagggt cctggttact gggtgaagat tcatcactta    360

gaatatacag atggaggaat cctggatcca gatgatgtct tggcagatgt tgttgaagat    420

aaagacaagc tgattgctgt gtttgaagaa caagaaccac tccacaagat tgagagcccc    480

agtggaaacc ctgcagatcg gcagagccca gatgcttttg agacagaagt ggccgcccaa    540

ctggccgcat ttaagccaat tggtggggag attgaagtaa ccccttctgc tctaaaacta    600

ggcactccac tgctggtgag gagaagcagt gacccagtgc caggcccacc tgctgatacc    660

cagccaagcg cttcacaccc tggtggccag agtctgaaac tggttgttcc agattccacg    720

cagaacttgg aagacagaga agttttgaat ggtgtacaga cagaactact aacttcgcca    780

agaactaagg acacattgag tgatatgaca agaacagtgg agatttctgg ggaaggaggc    840

ccattgggaa tacatgtagt gcccttcttt tcatctctga gtggaaggat tctaggactc    900

ttcatccgag gcattgaaga caacagcagg tccaagcggg agggactatt tcacgaaaat    960

gaatgtattg taaaaatcaa caatgtggat ctcgtagaca aaacctttgc tcaggctcaa   1020

gatgtcttcc gccaggcaat gaaatctcca agtgtgctcc tccacgtgct tcctccacaa   1080

aaccgtgaac agtatgaaaa gtcagtcatt ggctctctta acatttttgg taataatgat   1140

ggcgttttga aaaccaaagt gccgcctcct gtccatggaa aatcgggact aaagacagca   1200

aatctcacag gaaccgatag tcctgaaaca gatgcatcag cttccctgca acaaaacaag   1260

agtccccgag taccaaggct gggaggaaaa ccatcctctc cctcactctc gcctctcatg   1320

ggatttggca gcaataaaaa tgcaaagaaa attaagattg acctaaagaa aggccctgaa   1380

ggacttggtt tcactgtggt taccagagac tcttccatac atggtcccgg tcccattttt   1440

gtaaaaaaca ttttaccaaa gggagcagca ataaaagatg gccgcctaca atcaggggac   1500

agaattttgg aggtaaatgg gagagatgtc accggacgaa cccaggaaga gcttgtggcc   1560

atgctcagga gcaccaagca gggggagaca gcatcgctgg tcattgcccg ccaagaagga   1620

cattttctgc cccgagagtt gaaaggagaa cctgactgct gtgcactctc tctggagaca   1680

agcgagcagc tcacctttga gatccccctg aatgattcag gttctgctgg cctcggggtg   1740

agcttaaaag ggaacaaatc cagagaaact ggaacagact tggggatttt tatcaaatcc   1800

atcattcatg gaggcgctgc ttttaaggat ggtcgtctgc gaatgaatga ccagctgatt   1860

gcagttaatg gggaatctct tttgggaaag tccaaccacg aagctatgga aacacttagg   1920

cggtcaatgt ccatggaggg aaacatccga gggatgatcc agttggtgat tctgaggagg   1980

ccagagagac caatggagga tcctgcagag tgtggggcat tttccaagcc atgctttgag   2040

aactgtcaaa atgctgtaac cacctctagg cgaaatgata atagtatcct gcatccactt   2100

ggcacttgca gtccacaaga caaacagaaa ggtctattgc tgcccaatga cggatgggcc   2160

gagagtgaag ttccaccttc tccaacacca cattctgctc tgggattggg cctcgaagat   2220

tacagccaca gctctggggt ggattcagca gtatattttc cagatcagca catcaacttc   2280

agatctgtga caccggccag gcagcctgaa tcaattaatt tgaaagcctc gaagagcatg   2340

gaccttgtgc cagatgaaag caaggttcac tcattggctg gacaaaaatc ggacggtctg   2400

tctgataaga gctctcactc tggccaagga gctctgaatt gtgagtctgc ccctcagggg   2460

aattcggagc tagaggacat ggaaaataaa gccaggaaag tcaaaaaaac gaaagagaag   2520

gagaagaaaa aggaaaaggg caaattgaaa gtcaaggaga aaaagcgcaa agaggagaat   2580

gaagatccag aaaggaaaat aaagaagaag ggcttcggcg ccatgctgag atttggaaag   2640

aagaaagagg ataagggtgg aaaggctgag cagaaaggta ctctgaaaca tggtggcctg   2700

agagaagaag agctggagaa aatgaaagaa gagcgtgaaa ggattggagc aaaacatcag   2760

gagctaaggg aaaagcaggc aagaggtctt cttgattatg ctactggtgc aattggatca   2820

gtgtatgata tggatgatga tgaaatggac cccaattatg ccagagtgaa ccactttcgg   2880

gaaccatgca catcagcaaa tgtctttaga tctccatctc cccctcgagc tggaccattt   2940

ggttaccctc gggatggcca tccactgtct ccagaaagag accacttaga gggtctctat   3000

gccaaggtca acaagccata ccatccactg gttccagctg acagtggccg tcctacgggt   3060

ggaagcactg accgtatcca gaagttgcgg aaagagtatt atcaggctcg gagggaaggt   3120

ttccctttat atgaagacga cgaaggaaga gcaaggccat ctgagtatga cctactctgg   3180

gtgcctggaa ggggtccaga tgggaatgca cacaacctcc gctttgaagg gatggagagg   3240

cagtacgcat ccttacccag gggaggaccc gcagatcctg tagactatct gccagcagca   3300

cctcgggggc tctacaagga aagggagctt ccctattatc caggggctca tcctatgcac   3360

cctcccaaag ggagctatcc ccgccccaca gagctcaggg tggcagatct ccggtatcct   3420

cagcactacc cacccccgcc agctccccag cacaaaggac cctttcgaca agacgttccg   3480

ccttcccctc cccagcacca aagaatgcca gcctatcagg aaacaggcag accagggccc   3540

cgtgggggca gcccagacca gtacccttac cgaacccagg attcccggca gaagaacccc   3600

atgactgcag ccgtatag                                                 3618


<210>  113
<211>  1136
<212>  PRT
<213>  Homo sapiens

<400>  113


Met Lys Val Thr Val Cys Phe Gly Arg Thr Gly Ile Val Val Pro Cys 
1               5                   10                  15      


Lys Glu Gly Gln Leu Arg Val Gly Glu Leu Thr Gln Gln Ala Leu Gln 
            20                  25                  30          


Arg Tyr Leu Lys Thr Arg Glu Lys Gly Pro Gly Tyr Trp Val Lys Ile 
        35                  40                  45              


His His Leu Glu Tyr Thr Asp Gly Gly Ile Leu Asp Pro Asp Asp Val 
    50                  55                  60                  


Leu Ala Asp Val Val Glu Asp Lys Asp Lys Leu Ile Ala Val Phe Glu 
65                  70                  75                  80  


Glu Gln Glu Pro Leu His Lys Ile Glu Ser Pro Ser Gly Asn Pro Ala 
                85                  90                  95      


Asp Arg Gln Ser Pro Asp Ala Phe Glu Thr Glu Val Ala Ala Gln Leu 
            100                 105                 110         


Ala Ala Phe Lys Pro Ile Gly Gly Glu Ile Glu Val Thr Pro Ser Ala 
        115                 120                 125             


Leu Lys Leu Gly Thr Pro Leu Leu Val Arg Arg Ser Ser Asp Pro Val 
    130                 135                 140                 


Pro Gly Pro Pro Ala Asp Thr Gln Pro Ser Ala Ser His Pro Gly Gly 
145                 150                 155                 160 


Gln Ser Leu Lys Leu Val Val Pro Asp Ser Thr Gln Asn Leu Glu Asp 
                165                 170                 175     


Arg Glu Val Leu Asn Gly Val Gln Thr Glu Leu Leu Thr Ser Pro Arg 
            180                 185                 190         


Thr Lys Asp Thr Leu Ser Asp Met Thr Arg Thr Val Glu Ile Ser Gly 
        195                 200                 205             


Glu Gly Gly Pro Leu Gly Ile His Val Val Pro Phe Phe Ser Ser Leu 
    210                 215                 220                 


Ser Gly Arg Ile Leu Gly Leu Phe Ile Arg Gly Ile Glu Asp Asn Ser 
225                 230                 235                 240 


Arg Ser Lys Arg Glu Gly Leu Phe His Glu Asn Glu Cys Ile Val Lys 
                245                 250                 255     


Ile Asn Asn Val Asp Leu Val Asp Lys Thr Phe Ala Gln Ala Gln Asp 
            260                 265                 270         


Val Phe Arg Gln Ala Met Lys Ser Pro Ser Val Leu Leu His Val Leu 
        275                 280                 285             


Pro Pro Gln Asn Arg Glu Gln Tyr Glu Lys Ser Val Ile Gly Ser Leu 
    290                 295                 300                 


Asn Ile Phe Gly Asn Asn Asp Gly Val Leu Lys Thr Lys Val Pro Pro 
305                 310                 315                 320 


Pro Val His Gly Lys Ser Gly Leu Lys Thr Ala Asn Leu Thr Gly Thr 
                325                 330                 335     


Asp Ser Pro Glu Thr Asp Ala Ser Ala Ser Leu Gln Gln Asn Lys Ser 
            340                 345                 350         


Pro Arg Val Pro Arg Leu Gly Gly Lys Pro Ser Ser Pro Ser Leu Ser 
        355                 360                 365             


Pro Leu Met Gly Phe Gly Ser Asn Lys Asn Ala Lys Lys Ile Lys Ile 
    370                 375                 380                 


Asp Leu Lys Lys Gly Pro Glu Gly Leu Gly Phe Thr Val Val Thr Arg 
385                 390                 395                 400 


Asp Ser Ser Ile His Gly Pro Gly Pro Ile Phe Val Lys Asn Ile Leu 
                405                 410                 415     


Pro Lys Gly Ala Ala Ile Lys Asp Gly Arg Leu Gln Ser Gly Asp Arg 
            420                 425                 430         


Ile Leu Glu Val Asn Gly Arg Asp Val Thr Gly Arg Thr Gln Glu Glu 
        435                 440                 445             


Leu Val Ala Met Leu Arg Ser Thr Lys Gln Gly Glu Thr Ala Ser Leu 
    450                 455                 460                 


Val Ile Ala Arg Gln Glu Gly His Phe Leu Pro Arg Glu Leu Lys Gly 
465                 470                 475                 480 


Glu Pro Asp Cys Cys Ala Leu Ser Leu Glu Thr Ser Glu Gln Leu Thr 
                485                 490                 495     


Phe Glu Ile Pro Leu Asn Asp Ser Gly Ser Ala Gly Leu Gly Val Ser 
            500                 505                 510         


Leu Lys Gly Asn Lys Ser Arg Glu Thr Gly Thr Asp Leu Gly Ile Phe 
        515                 520                 525             


Ile Lys Ser Ile Ile His Gly Gly Ala Ala Phe Lys Asp Gly Arg Leu 
    530                 535                 540                 


Arg Met Asn Asp Gln Leu Ile Ala Val Asn Gly Glu Ser Leu Leu Gly 
545                 550                 555                 560 


Lys Ser Asn His Glu Ala Met Glu Thr Leu Arg Arg Ser Met Ser Met 
                565                 570                 575     


Glu Gly Asn Ile Arg Gly Met Ile Gln Leu Val Ile Leu Arg Arg Pro 
            580                 585                 590         


Glu Arg Pro Met Glu Asp Pro Ala Glu Cys Gly Ala Phe Ser Lys Pro 
        595                 600                 605             


Cys Phe Glu Asn Cys Gln Asn Ala Val Thr Thr Ser Arg Arg Asn Asp 
    610                 615                 620                 


Asn Ser Ile Leu His Pro Leu Gly Thr Cys Ser Pro Gln Asp Lys Gln 
625                 630                 635                 640 


Lys Gly Leu Leu Leu Pro Asn Asp Gly Trp Ala Glu Ser Glu Val Pro 
                645                 650                 655     


Pro Ser Pro Thr Pro His Ser Ala Leu Gly Leu Gly Leu Glu Asp Tyr 
            660                 665                 670         


Ser His Ser Ser Gly Val Asp Ser Ala Val Tyr Phe Pro Asp Gln His 
        675                 680                 685             


Ile Asn Phe Arg Ser Val Thr Pro Ala Arg Gln Pro Glu Ser Ile Asn 
    690                 695                 700                 


Leu Lys Ala Ser Lys Ser Met Asp Leu Val Pro Asp Glu Ser Lys Val 
705                 710                 715                 720 


His Ser Leu Ala Gly Gln Lys Ser Asp Gly Leu Ser Asp Lys Ser Ser 
                725                 730                 735     


His Ser Gly Gln Gly Ala Leu Asn Cys Glu Ser Ala Pro Gln Gly Asn 
            740                 745                 750         


Ser Glu Leu Glu Asp Met Glu Asn Lys Ala Arg Lys Val Lys Lys Thr 
        755                 760                 765             


Lys Glu Lys Glu Lys Lys Lys Glu Lys Gly Lys Leu Lys Val Lys Glu 
    770                 775                 780                 


Lys Lys Arg Lys Glu Glu Asn Glu Asp Pro Glu Arg Lys Ile Lys Lys 
785                 790                 795                 800 


Lys Gly Phe Gly Ala Met Leu Arg Phe Gly Lys Lys Lys Glu Asp Lys 
                805                 810                 815     


Gly Gly Lys Ala Glu Gln Lys Gly Thr Leu Lys His Gly Gly Leu Arg 
            820                 825                 830         


Glu Glu Glu Leu Glu Lys Met Lys Glu Glu Arg Glu Arg Ile Gly Ala 
        835                 840                 845             


Lys His Gln Glu Leu Arg Glu Lys Gln Ala Arg Gly Leu Leu Asp Tyr 
    850                 855                 860                 


Ala Thr Gly Ala Ile Gly Ser Val Tyr Asp Met Asp Asp Asp Glu Met 
865                 870                 875                 880 


Asp Pro Asn Tyr Ala Arg Val Asn His Phe Arg Glu Pro Cys Thr Ser 
                885                 890                 895     


Ala Asn Val Phe Arg Ser Pro Ser Pro Pro Arg Ala Gly Pro Phe Gly 
            900                 905                 910         


Tyr Pro Arg Asp Gly His Pro Leu Ser Pro Glu Arg Asp His Leu Glu 
        915                 920                 925             


Gly Leu Tyr Ala Lys Val Asn Lys Pro Tyr His Pro Leu Val Pro Ala 
    930                 935                 940                 


Asp Ser Gly Arg Pro Thr Gly Gly Ser Thr Asp Arg Ile Gln Lys Leu 
945                 950                 955                 960 


Arg Lys Glu Tyr Tyr Gln Ala Arg Arg Glu Gly Phe Pro Leu Tyr Glu 
                965                 970                 975     


Asp Asp Glu Gly Arg Ala Arg Pro Ser Glu Tyr Asp Leu Leu Trp Val 
            980                 985                 990         


Pro Gly Arg Gly Pro Asp Gly Asn  Ala His Asn Leu Arg  Phe Glu Gly 
        995                 1000                 1005             


Met Glu  Arg Gln Tyr Ala Ser  Leu Pro Arg Gly Gly  Pro Ala Asp 
    1010                 1015                 1020             


Pro Val  Asp Tyr Leu Pro Ala  Ala Pro Arg Gly Leu  Tyr Lys Glu 
    1025                 1030                 1035             


Arg Glu  Leu Pro Tyr Tyr Pro  Gly Ala His Pro Met  His Pro Pro 
    1040                 1045                 1050             


Lys Gly  Ser Tyr Pro Arg Pro  Thr Glu Leu Arg Val  Ala Asp Leu 
    1055                 1060                 1065             


Arg Tyr  Pro Gln His Tyr Pro  Pro Pro Pro Ala Pro  Gln His Lys 
    1070                 1075                 1080             


Gly Pro  Phe Arg Gln Asp Val  Pro Pro Ser Pro Pro  Gln His Gln 
    1085                 1090                 1095             


Arg Met  Pro Ala Tyr Gln Glu  Thr Gly Arg Pro Gly  Pro Arg Gly 
    1100                 1105                 1110             


Gly Ser  Pro Asp Gln Tyr Pro  Tyr Arg Thr Gln Asp  Ser Arg Gln 
    1115                 1120                 1125             


Lys Asn  Pro Met Thr Ala Ala  Val 
    1130                 1135     

<210>  114
<211>  3639
<212>  DNA
<213>  Homo sapiens

<400>  114
gcggccgccc ctccccgatt cccgccacct gccgcctggc caggtggaag gggcgctgcc     60

gcgagcctcc gggcctcagg gtgttccggg gagcggcgcc ccgggtctct gggcccaccc    120

gccccgggcg tcctccgaga gtgggggctg cgcccgcggg gtcagacacc tgttcggccc    180

ggcccggcgt ggtcgccggg ggccaggatg aaagtgaccg tgtgcttcgg caggacgggc    240

atcgtggtgc cctgcaagga gggccagctg cgcgtcggcg agctcaccca gcaggcgctg    300

cagcggtacc tgaagacccg ggagaagggt cctggttact gggtgaagat tcatcactta    360

gaatatacag atggaggaat cctggatcca gatgatgtct tggcagatgt tgttgaagat    420

aaagacaagc tgattgctgt gtttgaagaa caagaaccac tccacaagat tgagagcccc    480

agtggaaacc ctgcagatcg gcagagccca gatgcttttg agacagaagt ggccgcccaa    540

ctggccgcat ttaagccaat tggtggggag attgaagtaa ccccttctgc tctaaaacta    600

ggcactccac tgctggtgag gagaagcagt gacccagtgc caggcccacc tgctgatacc    660

cagccaagcg cttcacaccc tggtggccag agtctgaaac tggttgttcc agattccacg    720

cagaacttgg aagacagaga agttttgaat ggtgtacaga cagaactact aacttcgcca    780

agaactaagg acacattgag tgatatgaca agaacagtgg agatttctgg ggaaggaggc    840

ccattgggaa tacatgtagt gcccttcttt tcatctctga gtggaaggat tctaggactc    900

ttcatccgag gcattgaaga caacagcagg tccaagcggg agggactatt tcacgaaaat    960

gaatgtattg taaaaatcaa caatgtggat ctcgtagaca aaacctttgc tcaggctcaa   1020

gatgtcttcc gccaggcaat gaaatctcca agtgtgctcc tccacgtgct tcctccacaa   1080

aaccgtgaac agtatgaaaa gtcagtcatt ggctctctta acatttttgg taataatgat   1140

ggcgttttga aaaccaaagt gccgcctcct gtccatggaa aatcgggact aaagacagca   1200

aatctcacag gaaccgatag tcctgaaaca gatgcatcag cttccctgca acaaaacaag   1260

agtccccgag taccaaggct gggaggaaaa ccatcctctc cctcactctc gcctctcatg   1320

ggatttggca gcaataaaaa tgcaaagaaa attaagattg acctaaagaa aggccctgaa   1380

ggacttggtt tcactgtggt taccagagac tcttccatac atggtcccgg tcccattttt   1440

gtaaaaaaca ttttaccaaa gggagcagca ataaaagatg gccgcctaca atcaggggac   1500

agaattttgg aggtaaatgg gagagatgtc accggacgaa cccaggaaga gcttgtggcc   1560

atgctcagga gcaccaagca gggggagaca gcatcgctgg tcattgcccg ccaagaagga   1620

cattttctgc cccgagagtt ggatggtcgt ctgcgaatga atgaccagct gattgcagtt   1680

aatggggaat ctcttttggg aaagtccaac cacgaagcta tggaaacact taggcggtca   1740

atgtccatgg agggaaacat ccgagggatg atccagttgg tgattctgag gaggccagag   1800

agaccaatgg aggatcctgc agagtgtggg gcattttcca agccatgctt tgagaactgt   1860

caaaatgctg taaccacctc taggcgaaat gataatagta tcctgcatcc acttggcact   1920

tgcagtccac aagacaaaca gaaaggtcta ttgctgccca atgacggatg ggccgagagt   1980

gaagttccac cttctccaac accacattct gctctgggat tgggcctcga agattacagc   2040

cacagctctg gggtggattc agcagtatat tttccagatc agcacatcaa cttcagatct   2100

gtgacaccgg ccaggcagcc tgaatcaatt aatttgaaag cctcgaagag catggacctt   2160

gtgccagatg aaagcaaggt tcactcattg gctggacaaa aatcggaatc tccaagcaaa   2220

gattttggtc caactctggg tttgaaaaag tccagctcct tggagagtct gcagactgca   2280

gtggccgagg tcaggaagaa tgaccttccc tttcacaggc cccggccgca catggttcga   2340

ggccgaggct gcaatgagag ctttagagca gccattgaca aatcctacga tggacctgaa   2400

gaaatagaag ctgacggtct gtctgataag agctctcact ctggccaagg agctctgaat   2460

tgtgagtctg cccctcaggg gaattcggag ctagaggaca tggaaaataa agccaggaaa   2520

gtcaaaaaaa cgaaagagaa ggagaagaaa aaggaaaagg gcaaattgaa agtcaaggag   2580

aaaaagcgca aagaggagaa tgaagatcca gaaaggaaaa taaagaagaa gggcttcggc   2640

gccatgctga gatttggaaa gaagaaagag gataagggtg gaaaggctga gcagaaaggt   2700

actctgaaac atggtggcct gagagaagaa gagctggaga aaatgaaaga agagcgtgaa   2760

aggattggag caaaacatca ggagctaagg gaaaagcagg caagaggtct tcttgattat   2820

gctactggtg caattggatc agtgtatgat atggatgatg atgaaatgga ccccaattat   2880

gccagagtga accactttcg ggaaccatgc acatcagcaa atgtctttag atctccatct   2940

ccccctcgag ctggaccatt tggttaccct cgggatggcc atccactgtc tccagaaaga   3000

gaccacttag agggtctcta tgccaaggtc aacaagccat accatccact ggttccagct   3060

gacagtggcc gtcctacggg tggaagcact gaccgtatcc agaagttgcg gaaagagtat   3120

tatcaggctc ggagggaagg tttcccttta tatgaagacg acgaaggaag agcaaggcca   3180

tctgagtatg acctactctg ggtgcctgga aggggtccag atgggaatgc acacaacctc   3240

cgctttgaag ggatggagag gcagtacgca tccttaccca ggggaggacc cgcagatcct   3300

gtagactatc tgccagcagc acctcggggg ctctacaagg aaagggagct tccctattat   3360

ccaggggctc atcctatgca ccctcccaaa gggagctatc cccgccccac agagctcagg   3420

gtggcagatc tccggtatcc tcagcactac ccacccccgc cagctcccca gcacaaagga   3480

ccctttcgac aagacgttcc gccttcccct ccccagcacc aaagaatgcc agcctatcag   3540

gaaacaggca gaccagggcc ccgtgggggc agcccagacc agtaccctta ccgaacccag   3600

gattcccggc agaagaaccc catgactgca gccgtatag                          3639


<210>  115
<211>  1143
<212>  PRT
<213>  Homo sapiens

<400>  115


Met Lys Val Thr Val Cys Phe Gly Arg Thr Gly Ile Val Val Pro Cys 
1               5                   10                  15      


Lys Glu Gly Gln Leu Arg Val Gly Glu Leu Thr Gln Gln Ala Leu Gln 
            20                  25                  30          


Arg Tyr Leu Lys Thr Arg Glu Lys Gly Pro Gly Tyr Trp Val Lys Ile 
        35                  40                  45              


His His Leu Glu Tyr Thr Asp Gly Gly Ile Leu Asp Pro Asp Asp Val 
    50                  55                  60                  


Leu Ala Asp Val Val Glu Asp Lys Asp Lys Leu Ile Ala Val Phe Glu 
65                  70                  75                  80  


Glu Gln Glu Pro Leu His Lys Ile Glu Ser Pro Ser Gly Asn Pro Ala 
                85                  90                  95      


Asp Arg Gln Ser Pro Asp Ala Phe Glu Thr Glu Val Ala Ala Gln Leu 
            100                 105                 110         


Ala Ala Phe Lys Pro Ile Gly Gly Glu Ile Glu Val Thr Pro Ser Ala 
        115                 120                 125             


Leu Lys Leu Gly Thr Pro Leu Leu Val Arg Arg Ser Ser Asp Pro Val 
    130                 135                 140                 


Pro Gly Pro Pro Ala Asp Thr Gln Pro Ser Ala Ser His Pro Gly Gly 
145                 150                 155                 160 


Gln Ser Leu Lys Leu Val Val Pro Asp Ser Thr Gln Asn Leu Glu Asp 
                165                 170                 175     


Arg Glu Val Leu Asn Gly Val Gln Thr Glu Leu Leu Thr Ser Pro Arg 
            180                 185                 190         


Thr Lys Asp Thr Leu Ser Asp Met Thr Arg Thr Val Glu Ile Ser Gly 
        195                 200                 205             


Glu Gly Gly Pro Leu Gly Ile His Val Val Pro Phe Phe Ser Ser Leu 
    210                 215                 220                 


Ser Gly Arg Ile Leu Gly Leu Phe Ile Arg Gly Ile Glu Asp Asn Ser 
225                 230                 235                 240 


Arg Ser Lys Arg Glu Gly Leu Phe His Glu Asn Glu Cys Ile Val Lys 
                245                 250                 255     


Ile Asn Asn Val Asp Leu Val Asp Lys Thr Phe Ala Gln Ala Gln Asp 
            260                 265                 270         


Val Phe Arg Gln Ala Met Lys Ser Pro Ser Val Leu Leu His Val Leu 
        275                 280                 285             


Pro Pro Gln Asn Arg Glu Gln Tyr Glu Lys Ser Val Ile Gly Ser Leu 
    290                 295                 300                 


Asn Ile Phe Gly Asn Asn Asp Gly Val Leu Lys Thr Lys Val Pro Pro 
305                 310                 315                 320 


Pro Val His Gly Lys Ser Gly Leu Lys Thr Ala Asn Leu Thr Gly Thr 
                325                 330                 335     


Asp Ser Pro Glu Thr Asp Ala Ser Ala Ser Leu Gln Gln Asn Lys Ser 
            340                 345                 350         


Pro Arg Val Pro Arg Leu Gly Gly Lys Pro Ser Ser Pro Ser Leu Ser 
        355                 360                 365             


Pro Leu Met Gly Phe Gly Ser Asn Lys Asn Ala Lys Lys Ile Lys Ile 
    370                 375                 380                 


Asp Leu Lys Lys Gly Pro Glu Gly Leu Gly Phe Thr Val Val Thr Arg 
385                 390                 395                 400 


Asp Ser Ser Ile His Gly Pro Gly Pro Ile Phe Val Lys Asn Ile Leu 
                405                 410                 415     


Pro Lys Gly Ala Ala Ile Lys Asp Gly Arg Leu Gln Ser Gly Asp Arg 
            420                 425                 430         


Ile Leu Glu Val Asn Gly Arg Asp Val Thr Gly Arg Thr Gln Glu Glu 
        435                 440                 445             


Leu Val Ala Met Leu Arg Ser Thr Lys Gln Gly Glu Thr Ala Ser Leu 
    450                 455                 460                 


Val Ile Ala Arg Gln Glu Gly His Phe Leu Pro Arg Glu Leu Asp Gly 
465                 470                 475                 480 


Arg Leu Arg Met Asn Asp Gln Leu Ile Ala Val Asn Gly Glu Ser Leu 
                485                 490                 495     


Leu Gly Lys Ser Asn His Glu Ala Met Glu Thr Leu Arg Arg Ser Met 
            500                 505                 510         


Ser Met Glu Gly Asn Ile Arg Gly Met Ile Gln Leu Val Ile Leu Arg 
        515                 520                 525             


Arg Pro Glu Arg Pro Met Glu Asp Pro Ala Glu Cys Gly Ala Phe Ser 
    530                 535                 540                 


Lys Pro Cys Phe Glu Asn Cys Gln Asn Ala Val Thr Thr Ser Arg Arg 
545                 550                 555                 560 


Asn Asp Asn Ser Ile Leu His Pro Leu Gly Thr Cys Ser Pro Gln Asp 
                565                 570                 575     


Lys Gln Lys Gly Leu Leu Leu Pro Asn Asp Gly Trp Ala Glu Ser Glu 
            580                 585                 590         


Val Pro Pro Ser Pro Thr Pro His Ser Ala Leu Gly Leu Gly Leu Glu 
        595                 600                 605             


Asp Tyr Ser His Ser Ser Gly Val Asp Ser Ala Val Tyr Phe Pro Asp 
    610                 615                 620                 


Gln His Ile Asn Phe Arg Ser Val Thr Pro Ala Arg Gln Pro Glu Ser 
625                 630                 635                 640 


Ile Asn Leu Lys Ala Ser Lys Ser Met Asp Leu Val Pro Asp Glu Ser 
                645                 650                 655     


Lys Val His Ser Leu Ala Gly Gln Lys Ser Glu Ser Pro Ser Lys Asp 
            660                 665                 670         


Phe Gly Pro Thr Leu Gly Leu Lys Lys Ser Ser Ser Leu Glu Ser Leu 
        675                 680                 685             


Gln Thr Ala Val Ala Glu Val Arg Lys Asn Asp Leu Pro Phe His Arg 
    690                 695                 700                 


Pro Arg Pro His Met Val Arg Gly Arg Gly Cys Asn Glu Ser Phe Arg 
705                 710                 715                 720 


Ala Ala Ile Asp Lys Ser Tyr Asp Gly Pro Glu Glu Ile Glu Ala Asp 
                725                 730                 735     


Gly Leu Ser Asp Lys Ser Ser His Ser Gly Gln Gly Ala Leu Asn Cys 
            740                 745                 750         


Glu Ser Ala Pro Gln Gly Asn Ser Glu Leu Glu Asp Met Glu Asn Lys 
        755                 760                 765             


Ala Arg Lys Val Lys Lys Thr Lys Glu Lys Glu Lys Lys Lys Glu Lys 
    770                 775                 780                 


Gly Lys Leu Lys Val Lys Glu Lys Lys Arg Lys Glu Glu Asn Glu Asp 
785                 790                 795                 800 


Pro Glu Arg Lys Ile Lys Lys Lys Gly Phe Gly Ala Met Leu Arg Phe 
                805                 810                 815     


Gly Lys Lys Lys Glu Asp Lys Gly Gly Lys Ala Glu Gln Lys Gly Thr 
            820                 825                 830         


Leu Lys His Gly Gly Leu Arg Glu Glu Glu Leu Glu Lys Met Lys Glu 
        835                 840                 845             


Glu Arg Glu Arg Ile Gly Ala Lys His Gln Glu Leu Arg Glu Lys Gln 
    850                 855                 860                 


Ala Arg Gly Leu Leu Asp Tyr Ala Thr Gly Ala Ile Gly Ser Val Tyr 
865                 870                 875                 880 


Asp Met Asp Asp Asp Glu Met Asp Pro Asn Tyr Ala Arg Val Asn His 
                885                 890                 895     


Phe Arg Glu Pro Cys Thr Ser Ala Asn Val Phe Arg Ser Pro Ser Pro 
            900                 905                 910         


Pro Arg Ala Gly Pro Phe Gly Tyr Pro Arg Asp Gly His Pro Leu Ser 
        915                 920                 925             


Pro Glu Arg Asp His Leu Glu Gly Leu Tyr Ala Lys Val Asn Lys Pro 
    930                 935                 940                 


Tyr His Pro Leu Val Pro Ala Asp Ser Gly Arg Pro Thr Gly Gly Ser 
945                 950                 955                 960 


Thr Asp Arg Ile Gln Lys Leu Arg Lys Glu Tyr Tyr Gln Ala Arg Arg 
                965                 970                 975     


Glu Gly Phe Pro Leu Tyr Glu Asp Asp Glu Gly Arg Ala Arg Pro Ser 
            980                 985                 990         


Glu Tyr Asp Leu Leu Trp Val Pro  Gly Arg Gly Pro Asp  Gly Asn Ala 
        995                 1000                 1005             


His Asn  Leu Arg Phe Glu Gly  Met Glu Arg Gln Tyr  Ala Ser Leu 
    1010                 1015                 1020             


Pro Arg  Gly Gly Pro Ala Asp  Pro Val Asp Tyr Leu  Pro Ala Ala 
    1025                 1030                 1035             


Pro Arg  Gly Leu Tyr Lys Glu  Arg Glu Leu Pro Tyr  Tyr Pro Gly 
    1040                 1045                 1050             


Ala His  Pro Met His Pro Pro  Lys Gly Ser Tyr Pro  Arg Pro Thr 
    1055                 1060                 1065             


Glu Leu  Arg Val Ala Asp Leu  Arg Tyr Pro Gln His  Tyr Pro Pro 
    1070                 1075                 1080             


Pro Pro  Ala Pro Gln His Lys  Gly Pro Phe Arg Gln  Asp Val Pro 
    1085                 1090                 1095             


Pro Ser  Pro Pro Gln His Gln  Arg Met Pro Ala Tyr  Gln Glu Thr 
    1100                 1105                 1110             


Gly Arg  Pro Gly Pro Arg Gly  Gly Ser Pro Asp Gln  Tyr Pro Tyr 
    1115                 1120                 1125             


Arg Thr  Gln Asp Ser Arg Gln  Lys Asn Pro Met Thr  Ala Ala Val 
    1130                 1135                 1140             

<210>  116
<211>  3522
<212>  DNA
<213>  Homo sapiens

<400>  116
gcggccgccc ctccccgatt cccgccacct gccgcctggc caggtggaag gggcgctgcc     60

gcgagcctcc gggcctcagg gtgttccggg gagcggcgcc ccgggtctct gggcccaccc    120

gccccgggcg tcctccgaga gtgggggctg cgcccgcggg gtcagacacc tgttcggccc    180

ggcccggcgt ggtcgccggg ggccaggatg aaagtgaccg tgtgcttcgg caggacgggc    240

atcgtggtgc cctgcaagga gggccagctg cgcgtcggcg agctcaccca gcaggcgctg    300

cagcggtacc tgaagacccg ggagaagggt cctggttact gggtgaagat tcatcactta    360

gaatatacag atggaggaat cctggatcca gatgatgtct tggcagatgt tgttgaagat    420

aaagacaagc tgattgctgt gtttgaagaa caagaaccac tccacaagat tgagagcccc    480

agtggaaacc ctgcagatcg gcagagccca gatgcttttg agacagaagt ggccgcccaa    540

ctggccgcat ttaagccaat tggtggggag attgaagtaa ccccttctgc tctaaaacta    600

ggcactccac tgctggtgag gagaagcagt gacccagtgc caggcccacc tgctgatacc    660

cagccaagcg cttcacaccc tggtggccag agtctgaaac tggttgttcc agattccacg    720

cagaacttgg aagacagaga agttttgaat ggtgtacaga cagaactact aacttcgcca    780

agaactaagg acacattgag tgatatgaca agaacagtgg agatttctgg ggaaggaggc    840

ccattgggaa tacatgtagt gcccttcttt tcatctctga gtggaaggat tctaggactc    900

ttcatccgag gcattgaaga caacagcagg tccaagcggg agggactatt tcacgaaaat    960

gaatgtattg taaaaatcaa caatgtggat ctcgtagaca aaacctttgc tcaggctcaa   1020

gatgtcttcc gccaggcaat gaaatctcca agtgtgctcc tccacgtgct tcctccacaa   1080

aaccgtgaac agtatgaaaa gtcagtcatt ggctctctta acatttttgg taataatgat   1140

ggcgttttga aaaccaaagt gccgcctcct gtccatggaa aatcgggact aaagacagca   1200

aatctcacag gaaccgatag tcctgaaaca gatgcatcag cttccctgca acaaaacaag   1260

agtccccgag taccaaggct gggaggaaaa ccatcctctc cctcactctc gcctctcatg   1320

ggatttggca gcaataaaaa tgcaaagaaa attaagattg acctaaagaa aggccctgaa   1380

ggacttggtt tcactgtggt taccagagac tcttccatac atggtcccgg tcccattttt   1440

gtaaaaaaca ttttaccaaa gggagcagca ataaaagatg gccgcctaca atcaggggac   1500

agaattttgg aggtaaatgg gagagatgtc accggacgaa cccaggaaga gcttgtggcc   1560

atgctcagga gcaccaagca gggggagaca gcatcgctgg tcattgcccg ccaagaagga   1620

cattttctgc cccgagagtt gaaaggagaa cctgactgct gtgcactctc tctggagaca   1680

agcgagcagc tcacctttga gatccccctg aatgattcag gttctgctgg cctcggggtg   1740

agcttaaaag ggaacaaatc cagagaaact ggaacagact tggggatttt tatcaaatcc   1800

atcattcatg gaggcgctgc ttttaaggat ggtcgtctgc gaatgaatga ccagctgatt   1860

gcagttaatg gggaatctct tttgggaaag tccaaccacg aagctatgga aacacttagg   1920

cggtcaatgt ccatggaggg aaacatccga gggatgatcc agttggtgat tctgaggagg   1980

ccagagagac caatggagga tcctgcagag tgtggggcat tttccaagcc atgctttgag   2040

aactgtcaaa atgctgtaac cacctctagg cgaaatgata atagtatcct gcatccactt   2100

ggcacttgca gtccacaaga caaacagaaa ggtctattgc tgcccaatga cggatgggcc   2160

gagagtgaag ttccaccttc tccaacacca cattctgctc tgggattggg cctcgaagat   2220

tacagccaca gctctggggt ggattcagca gtatattttc cagatcagca catcaacttc   2280

agatctgtga caccggccag gcagcctgaa tcaattaatt tgaaagcctc gaagagcatg   2340

gaccttgtgc cagatgaaag caaggttcac tcattggctg gacaaaaatc ggaatctcca   2400

agcaaagatt ttggtccaac tctgggtttg aaaaagtcca gctccttgga gagtctgcag   2460

actgcagtgg ccgaggtcag gaagaatgac cttccctttc acaggccccg gccgcacatg   2520

gttcgaggcc gaggctgcaa tgagagcttt agagcagcca ttgacaaatc ctacgatgga   2580

cctgaagaaa tagaagctga cggtctgtct gataagagct ctcactctgg ccaaggagct   2640

ctgaattgtg agtctgcccc tcaggggaat tcggagctag aggacatgga aaataaagcc   2700

aggaaagtca aaaaaacgaa agagaaggag aagaaaaagg aaaagggcaa attgaaagtc   2760

aaggagaaaa agcgcaaaga ggagaatgaa gatccagaaa ggaaaataaa gaagaagggc   2820

ttcggcgcca tgctgagatt tggaaagaag aaagaggata agggtggaaa ggctgagcag   2880

aaaggtactc tgaaacatgg tggcctgaga gaagaagagc tggagaaaat gaaagaagag   2940

cgtgaaagtg gccgtcctac gggtggaagc actgaccgta tccagaagtt gcggaaagag   3000

tattatcagg ctcggaggga aggtttccct ttatatgaag acgacgaagg aagagcaagg   3060

ccatctgagt atgacctact ctgggtgcct ggaaggggtc cagatgggaa tgcacacaac   3120

ctccgctttg aagggatgga gaggcagtac gcatccttac ccaggggagg acccgcagat   3180

cctgtagact atctgccagc agcacctcgg gggctctaca aggaaaggga gcttccctat   3240

tatccagggg ctcatcctat gcaccctccc aaagggagct atccccgccc cacagagctc   3300

agggtggcag atctccggta tcctcagcac tacccacccc cgccagctcc ccagcacaaa   3360

ggaccctttc gacaagacgt tccgccttcc cctccccagc accaaagaat gccagcctat   3420

caggaaacag gcagaccagg gccccgtggg ggcagcccag accagtaccc ttaccgaacc   3480

caggattccc ggcagaagaa ccccatgact gcagccgtat ag                      3522


<210>  117
<211>  1104
<212>  PRT
<213>  Homo sapiens

<400>  117


Met Lys Val Thr Val Cys Phe Gly Arg Thr Gly Ile Val Val Pro Cys 
1               5                   10                  15      


Lys Glu Gly Gln Leu Arg Val Gly Glu Leu Thr Gln Gln Ala Leu Gln 
            20                  25                  30          


Arg Tyr Leu Lys Thr Arg Glu Lys Gly Pro Gly Tyr Trp Val Lys Ile 
        35                  40                  45              


His His Leu Glu Tyr Thr Asp Gly Gly Ile Leu Asp Pro Asp Asp Val 
    50                  55                  60                  


Leu Ala Asp Val Val Glu Asp Lys Asp Lys Leu Ile Ala Val Phe Glu 
65                  70                  75                  80  


Glu Gln Glu Pro Leu His Lys Ile Glu Ser Pro Ser Gly Asn Pro Ala 
                85                  90                  95      


Asp Arg Gln Ser Pro Asp Ala Phe Glu Thr Glu Val Ala Ala Gln Leu 
            100                 105                 110         


Ala Ala Phe Lys Pro Ile Gly Gly Glu Ile Glu Val Thr Pro Ser Ala 
        115                 120                 125             


Leu Lys Leu Gly Thr Pro Leu Leu Val Arg Arg Ser Ser Asp Pro Val 
    130                 135                 140                 


Pro Gly Pro Pro Ala Asp Thr Gln Pro Ser Ala Ser His Pro Gly Gly 
145                 150                 155                 160 


Gln Ser Leu Lys Leu Val Val Pro Asp Ser Thr Gln Asn Leu Glu Asp 
                165                 170                 175     


Arg Glu Val Leu Asn Gly Val Gln Thr Glu Leu Leu Thr Ser Pro Arg 
            180                 185                 190         


Thr Lys Asp Thr Leu Ser Asp Met Thr Arg Thr Val Glu Ile Ser Gly 
        195                 200                 205             


Glu Gly Gly Pro Leu Gly Ile His Val Val Pro Phe Phe Ser Ser Leu 
    210                 215                 220                 


Ser Gly Arg Ile Leu Gly Leu Phe Ile Arg Gly Ile Glu Asp Asn Ser 
225                 230                 235                 240 


Arg Ser Lys Arg Glu Gly Leu Phe His Glu Asn Glu Cys Ile Val Lys 
                245                 250                 255     


Ile Asn Asn Val Asp Leu Val Asp Lys Thr Phe Ala Gln Ala Gln Asp 
            260                 265                 270         


Val Phe Arg Gln Ala Met Lys Ser Pro Ser Val Leu Leu His Val Leu 
        275                 280                 285             


Pro Pro Gln Asn Arg Glu Gln Tyr Glu Lys Ser Val Ile Gly Ser Leu 
    290                 295                 300                 


Asn Ile Phe Gly Asn Asn Asp Gly Val Leu Lys Thr Lys Val Pro Pro 
305                 310                 315                 320 


Pro Val His Gly Lys Ser Gly Leu Lys Thr Ala Asn Leu Thr Gly Thr 
                325                 330                 335     


Asp Ser Pro Glu Thr Asp Ala Ser Ala Ser Leu Gln Gln Asn Lys Ser 
            340                 345                 350         


Pro Arg Val Pro Arg Leu Gly Gly Lys Pro Ser Ser Pro Ser Leu Ser 
        355                 360                 365             


Pro Leu Met Gly Phe Gly Ser Asn Lys Asn Ala Lys Lys Ile Lys Ile 
    370                 375                 380                 


Asp Leu Lys Lys Gly Pro Glu Gly Leu Gly Phe Thr Val Val Thr Arg 
385                 390                 395                 400 


Asp Ser Ser Ile His Gly Pro Gly Pro Ile Phe Val Lys Asn Ile Leu 
                405                 410                 415     


Pro Lys Gly Ala Ala Ile Lys Asp Gly Arg Leu Gln Ser Gly Asp Arg 
            420                 425                 430         


Ile Leu Glu Val Asn Gly Arg Asp Val Thr Gly Arg Thr Gln Glu Glu 
        435                 440                 445             


Leu Val Ala Met Leu Arg Ser Thr Lys Gln Gly Glu Thr Ala Ser Leu 
    450                 455                 460                 


Val Ile Ala Arg Gln Glu Gly His Phe Leu Pro Arg Glu Leu Lys Gly 
465                 470                 475                 480 


Glu Pro Asp Cys Cys Ala Leu Ser Leu Glu Thr Ser Glu Gln Leu Thr 
                485                 490                 495     


Phe Glu Ile Pro Leu Asn Asp Ser Gly Ser Ala Gly Leu Gly Val Ser 
            500                 505                 510         


Leu Lys Gly Asn Lys Ser Arg Glu Thr Gly Thr Asp Leu Gly Ile Phe 
        515                 520                 525             


Ile Lys Ser Ile Ile His Gly Gly Ala Ala Phe Lys Asp Gly Arg Leu 
    530                 535                 540                 


Arg Met Asn Asp Gln Leu Ile Ala Val Asn Gly Glu Ser Leu Leu Gly 
545                 550                 555                 560 


Lys Ser Asn His Glu Ala Met Glu Thr Leu Arg Arg Ser Met Ser Met 
                565                 570                 575     


Glu Gly Asn Ile Arg Gly Met Ile Gln Leu Val Ile Leu Arg Arg Pro 
            580                 585                 590         


Glu Arg Pro Met Glu Asp Pro Ala Glu Cys Gly Ala Phe Ser Lys Pro 
        595                 600                 605             


Cys Phe Glu Asn Cys Gln Asn Ala Val Thr Thr Ser Arg Arg Asn Asp 
    610                 615                 620                 


Asn Ser Ile Leu His Pro Leu Gly Thr Cys Ser Pro Gln Asp Lys Gln 
625                 630                 635                 640 


Lys Gly Leu Leu Leu Pro Asn Asp Gly Trp Ala Glu Ser Glu Val Pro 
                645                 650                 655     


Pro Ser Pro Thr Pro His Ser Ala Leu Gly Leu Gly Leu Glu Asp Tyr 
            660                 665                 670         


Ser His Ser Ser Gly Val Asp Ser Ala Val Tyr Phe Pro Asp Gln His 
        675                 680                 685             


Ile Asn Phe Arg Ser Val Thr Pro Ala Arg Gln Pro Glu Ser Ile Asn 
    690                 695                 700                 


Leu Lys Ala Ser Lys Ser Met Asp Leu Val Pro Asp Glu Ser Lys Val 
705                 710                 715                 720 


His Ser Leu Ala Gly Gln Lys Ser Glu Ser Pro Ser Lys Asp Phe Gly 
                725                 730                 735     


Pro Thr Leu Gly Leu Lys Lys Ser Ser Ser Leu Glu Ser Leu Gln Thr 
            740                 745                 750         


Ala Val Ala Glu Val Arg Lys Asn Asp Leu Pro Phe His Arg Pro Arg 
        755                 760                 765             


Pro His Met Val Arg Gly Arg Gly Cys Asn Glu Ser Phe Arg Ala Ala 
    770                 775                 780                 


Ile Asp Lys Ser Tyr Asp Gly Pro Glu Glu Ile Glu Ala Asp Gly Leu 
785                 790                 795                 800 


Ser Asp Lys Ser Ser His Ser Gly Gln Gly Ala Leu Asn Cys Glu Ser 
                805                 810                 815     


Ala Pro Gln Gly Asn Ser Glu Leu Glu Asp Met Glu Asn Lys Ala Arg 
            820                 825                 830         


Lys Val Lys Lys Thr Lys Glu Lys Glu Lys Lys Lys Glu Lys Gly Lys 
        835                 840                 845             


Leu Lys Val Lys Glu Lys Lys Arg Lys Glu Glu Asn Glu Asp Pro Glu 
    850                 855                 860                 


Arg Lys Ile Lys Lys Lys Gly Phe Gly Ala Met Leu Arg Phe Gly Lys 
865                 870                 875                 880 


Lys Lys Glu Asp Lys Gly Gly Lys Ala Glu Gln Lys Gly Thr Leu Lys 
                885                 890                 895     


His Gly Gly Leu Arg Glu Glu Glu Leu Glu Lys Met Lys Glu Glu Arg 
            900                 905                 910         


Glu Ser Gly Arg Pro Thr Gly Gly Ser Thr Asp Arg Ile Gln Lys Leu 
        915                 920                 925             


Arg Lys Glu Tyr Tyr Gln Ala Arg Arg Glu Gly Phe Pro Leu Tyr Glu 
    930                 935                 940                 


Asp Asp Glu Gly Arg Ala Arg Pro Ser Glu Tyr Asp Leu Leu Trp Val 
945                 950                 955                 960 


Pro Gly Arg Gly Pro Asp Gly Asn Ala His Asn Leu Arg Phe Glu Gly 
                965                 970                 975     


Met Glu Arg Gln Tyr Ala Ser Leu Pro Arg Gly Gly Pro Ala Asp Pro 
            980                 985                 990         


Val Asp Tyr Leu Pro Ala Ala Pro  Arg Gly Leu Tyr Lys  Glu Arg Glu 
        995                 1000                 1005             


Leu Pro  Tyr Tyr Pro Gly Ala  His Pro Met His Pro  Pro Lys Gly 
    1010                 1015                 1020             


Ser Tyr  Pro Arg Pro Thr Glu  Leu Arg Val Ala Asp  Leu Arg Tyr 
    1025                 1030                 1035             


Pro Gln  His Tyr Pro Pro Pro  Pro Ala Pro Gln His  Lys Gly Pro 
    1040                 1045                 1050             


Phe Arg  Gln Asp Val Pro Pro  Ser Pro Pro Gln His  Gln Arg Met 
    1055                 1060                 1065             


Pro Ala  Tyr Gln Glu Thr Gly  Arg Pro Gly Pro Arg  Gly Gly Ser 
    1070                 1075                 1080             


Pro Asp  Gln Tyr Pro Tyr Arg  Thr Gln Asp Ser Arg  Gln Lys Asn 
    1085                 1090                 1095             


Pro Met  Thr Ala Ala Val 
    1100                 

<210>  118
<211>  1296
<212>  DNA
<213>  Homo sapiens

<400>  118
gagagctccc gggggccgtt gggtagcgtc ttcgctgttg cccttaggga cggctgtggg     60

cctgctgggg gtgggggccc gaagcgccag agatggctgc tcagcgaggg atgcccagct    120

ccgccgtgag ggtcctggaa gaggcgttgg gcatgggttt gacggcagcc ggggacgcga    180

gggacacggc ggacgcggtg gcggctgagg gcgcctacta cctggaacag gtcaccataa    240

ctgaagcatc tgaagatgac tatgaatatg aagagatacc agatgacaat tttagcatcc    300

cagaaggtga agaagatctg gcaaaagcaa ttcagatggc ccaagaacag gctacagata    360

ctgaaatttt ggaacggaaa acagttcttc cttcaaagca tgcagtacct gaagtaatag    420

aagactttct ctgcaatttc ttgatcaaaa tgggaatgac cagaactctt gattgctttc    480

agtctgaatg gtatgagtta atacagaaag gagtgactga acttagaact gttgggaatg    540

ttccagatgt ctacacccag attatgcttt tggaaaatga gaacaaaaat ttaaagaaag    600

atttgaagca ctacaaacaa gcagctgagt atgttatttt ttaaatgaca ttttcttctt    660

tttcttttgg actaaataaa agagttgagt gaagctgata tatgtaatat accagagcct    720

taatttttga aaactgaatt tttctagttg taaagaatgt gagaggcttc attagcaaat    780

taattaaaca gatgatcaga actatcacaa ttataactta ccaacaagaa gggaatgcag    840

gtagttgttt aggagatggt acatttttta tataacattc acttccttgt gtatttgata    900

gtcttttcat ggtttataac attttctcct gtaaagatag gctaatttct gaaataataa    960

ttaaatttat agaaagccga gaggaaattg ctagtttatt cctggtagag gaatttctgt   1020

atttgaaaat tctccagaag gaataatata aactgtggac tttgggtgat aatgatatgt   1080

aggttcgtca gttgttaaca aatgtatccc tctgttgggg gctattgata atggggaagg   1140

ctgtgcatgt gtgggagtag gaggtgtatg ggacatctct gtaccttcta atcaattttg   1200

ctatgaactt aaaactgctc taaaaataaa gtttattaaa aaaaagttaa aaaaaaaaaa   1260

aaaaaaaaaa aaaaaaaaaa agaaaaaaaa aaaaaa                             1296


<210>  119
<211>  183
<212>  PRT
<213>  Homo sapiens

<400>  119


Met Ala Ala Gln Arg Gly Met Pro Ser Ser Ala Val Arg Val Leu Glu 
1               5                   10                  15      


Glu Ala Leu Gly Met Gly Leu Thr Ala Ala Gly Asp Ala Arg Asp Thr 
            20                  25                  30          


Ala Asp Ala Val Ala Ala Glu Gly Ala Tyr Tyr Leu Glu Gln Val Thr 
        35                  40                  45              


Ile Thr Glu Ala Ser Glu Asp Asp Tyr Glu Tyr Glu Glu Ile Pro Asp 
    50                  55                  60                  


Asp Asn Phe Ser Ile Pro Glu Gly Glu Glu Asp Leu Ala Lys Ala Ile 
65                  70                  75                  80  


Gln Met Ala Gln Glu Gln Ala Thr Asp Thr Glu Ile Leu Glu Arg Lys 
                85                  90                  95      


Thr Val Leu Pro Ser Lys His Ala Val Pro Glu Val Ile Glu Asp Phe 
            100                 105                 110         


Leu Cys Asn Phe Leu Ile Lys Met Gly Met Thr Arg Thr Leu Asp Cys 
        115                 120                 125             


Phe Gln Ser Glu Trp Tyr Glu Leu Ile Gln Lys Gly Val Thr Glu Leu 
    130                 135                 140                 


Arg Thr Val Gly Asn Val Pro Asp Val Tyr Thr Gln Ile Met Leu Leu 
145                 150                 155                 160 


Glu Asn Glu Asn Lys Asn Leu Lys Lys Asp Leu Lys His Tyr Lys Gln 
                165                 170                 175     


Ala Ala Glu Tyr Val Ile Phe 
            180             

<210>  120
<211>  2189
<212>  DNA
<213>  Homo sapiens

<400>  120
gagagctccc gggggccgtt gggtagcgtc ttcgctgttg cccttaggga cggctgtggg     60

cctgctgggg gtgggggccc gaagcgccag agatggctgc tcagcgaggg atgcccagct    120

ccgccgtgag ggtcctggaa gaggcgttgg gcatgggttt gacggcagcc ggggacgcga    180

gggacacggc ggacgcggtg gcggctgagg gcgcctacta cctggaacag gtcaccataa    240

ctgaagcatc tgaagatgac tatgaatatg aagagatacc agatgacaat tttagcatcc    300

cagaaggtga agaagatctg gcaaaagcaa ttcagatggc ccaagaacag gctacagata    360

ctgaaatttt ggaacggaaa acagttcttc cttcaaagca tgcagtacct gaagtaatag    420

aagactttct ctgcaatttc ttgatcaaaa tgggaatgac cagaactctt gattgctttc    480

agtctgaatg gtatgagtta atacagaaag gagtgactga acttagaact gttgggaatg    540

ttccagatgt ctacacccag attatgcttt tggaaaatga gaacaaaaat ttaaagaaag    600

atttgaagca ctacaaacaa gcagctgaca aagctagaga agatttgctg aaaattcaga    660

aagaacgtga ttttcatcga atgcatcata agcgaatagt ccaggaaaaa aacaaattaa    720

ttaatgacct caaagggttg aagttacatt atgcatctta tgaaccgact ataagggtgt    780

tacatgagaa acaccacact ttactgaagg agaaaatgct gacctccttg gaaagagaca    840

aagtagttgg gcagatttct ggacttcaag aaacattgaa gaaactgcaa agaggacata    900

gttaccatgg tcctcaaatt aaagttgatc atagtcgtga aaaagaaaat gcaccagaag    960

gtcctactca gaaaggtctt cgtgaagcca gggaacaaaa caaatgtaaa acaaagatga   1020

aaggcaatac aaaggattca gaatttccca tagatatgca accaaatcca aacctgaatg   1080

tttctaaaga aagtctttct ccagcaaaat ttgactacaa gctgaaaaac atttttagac   1140

tccatgaact tccagtgagc tgtgtctcca tgcaacccca caaagacatc ctagtctcct   1200

gtggcgagga ccgactctgg aaggtgttgg gccttccaaa atgcaatgtg cttctcacgg   1260

gatttggcca cactgactgg ctttcagact gctgcttcca tcccagtggc gacaaattgg   1320

ctacttcaag tggtgacact acagttaaat tatgggatct atgtaaaggc gattgcattt   1380

tgacctttga aggacacagc cgcgcagtgt ggtcctgcac atggcactcc tgcggcaatt   1440

ttgtggcttc ctcctcactg gataaaacta gcaaaatttg ggatgttaat agtgaaagat   1500

gcagatgtac tttgtatgga catacagatt ctgtgaacag cattgagttt tttcctttct   1560

ccaatactct tctcacaagc tctgcagaca agaccctgtc tatatgggat gcaagaacag   1620

gtatatgtga gcagtcactt tatggtcaca tgcattctat caatgatgcc atttttgatc   1680

ccaggggtca catgatagca tcctgtgatg cctgtggggt tacaaagctg tgggactttc   1740

ggaagctgtt accaattgtg tccatcgata taggtccaag tcctggcaat gaggtgaatt   1800

ttgattcatc aggtcgagtt ttagctcagg caagtggcaa tggtgttatc catttgctag   1860

atcttaaatc tggggagatt cacaaattga tgggccacga aaacgaggca cacacggttg   1920

tgttttctca cgacggggag attctctttt ctggaggctc tgacggcaca gttcgaacgt   1980

ggtcttgacc gtcagcacat cccgctgcag agggcattcc ctttaaggct tgaaaatgcc   2040

tcctgtagtc ccaaaccagc aaagaactgg ttaaatgtgc cagcaggtaa catttacagt   2100

ctgctttaaa acatgctttg gacatatatt ttagtgctca tactgttact aataaaaaaa   2160

taactttatg ctcaaaaaaa aaaaaaaaa                                     2189


<210>  121
<211>  631
<212>  PRT
<213>  Homo sapiens

<400>  121


Met Ala Ala Gln Arg Gly Met Pro Ser Ser Ala Val Arg Val Leu Glu 
1               5                   10                  15      


Glu Ala Leu Gly Met Gly Leu Thr Ala Ala Gly Asp Ala Arg Asp Thr 
            20                  25                  30          


Ala Asp Ala Val Ala Ala Glu Gly Ala Tyr Tyr Leu Glu Gln Val Thr 
        35                  40                  45              


Ile Thr Glu Ala Ser Glu Asp Asp Tyr Glu Tyr Glu Glu Ile Pro Asp 
    50                  55                  60                  


Asp Asn Phe Ser Ile Pro Glu Gly Glu Glu Asp Leu Ala Lys Ala Ile 
65                  70                  75                  80  


Gln Met Ala Gln Glu Gln Ala Thr Asp Thr Glu Ile Leu Glu Arg Lys 
                85                  90                  95      


Thr Val Leu Pro Ser Lys His Ala Val Pro Glu Val Ile Glu Asp Phe 
            100                 105                 110         


Leu Cys Asn Phe Leu Ile Lys Met Gly Met Thr Arg Thr Leu Asp Cys 
        115                 120                 125             


Phe Gln Ser Glu Trp Tyr Glu Leu Ile Gln Lys Gly Val Thr Glu Leu 
    130                 135                 140                 


Arg Thr Val Gly Asn Val Pro Asp Val Tyr Thr Gln Ile Met Leu Leu 
145                 150                 155                 160 


Glu Asn Glu Asn Lys Asn Leu Lys Lys Asp Leu Lys His Tyr Lys Gln 
                165                 170                 175     


Ala Ala Asp Lys Ala Arg Glu Asp Leu Leu Lys Ile Gln Lys Glu Arg 
            180                 185                 190         


Asp Phe His Arg Met His His Lys Arg Ile Val Gln Glu Lys Asn Lys 
        195                 200                 205             


Leu Ile Asn Asp Leu Lys Gly Leu Lys Leu His Tyr Ala Ser Tyr Glu 
    210                 215                 220                 


Pro Thr Ile Arg Val Leu His Glu Lys His His Thr Leu Leu Lys Glu 
225                 230                 235                 240 


Lys Met Leu Thr Ser Leu Glu Arg Asp Lys Val Val Gly Gln Ile Ser 
                245                 250                 255     


Gly Leu Gln Glu Thr Leu Lys Lys Leu Gln Arg Gly His Ser Tyr His 
            260                 265                 270         


Gly Pro Gln Ile Lys Val Asp His Ser Arg Glu Lys Glu Asn Ala Pro 
        275                 280                 285             


Glu Gly Pro Thr Gln Lys Gly Leu Arg Glu Ala Arg Glu Gln Asn Lys 
    290                 295                 300                 


Cys Lys Thr Lys Met Lys Gly Asn Thr Lys Asp Ser Glu Phe Pro Ile 
305                 310                 315                 320 


Asp Met Gln Pro Asn Pro Asn Leu Asn Val Ser Lys Glu Ser Leu Ser 
                325                 330                 335     


Pro Ala Lys Phe Asp Tyr Lys Leu Lys Asn Ile Phe Arg Leu His Glu 
            340                 345                 350         


Leu Pro Val Ser Cys Val Ser Met Gln Pro His Lys Asp Ile Leu Val 
        355                 360                 365             


Ser Cys Gly Glu Asp Arg Leu Trp Lys Val Leu Gly Leu Pro Lys Cys 
    370                 375                 380                 


Asn Val Leu Leu Thr Gly Phe Gly His Thr Asp Trp Leu Ser Asp Cys 
385                 390                 395                 400 


Cys Phe His Pro Ser Gly Asp Lys Leu Ala Thr Ser Ser Gly Asp Thr 
                405                 410                 415     


Thr Val Lys Leu Trp Asp Leu Cys Lys Gly Asp Cys Ile Leu Thr Phe 
            420                 425                 430         


Glu Gly His Ser Arg Ala Val Trp Ser Cys Thr Trp His Ser Cys Gly 
        435                 440                 445             


Asn Phe Val Ala Ser Ser Ser Leu Asp Lys Thr Ser Lys Ile Trp Asp 
    450                 455                 460                 


Val Asn Ser Glu Arg Cys Arg Cys Thr Leu Tyr Gly His Thr Asp Ser 
465                 470                 475                 480 


Val Asn Ser Ile Glu Phe Phe Pro Phe Ser Asn Thr Leu Leu Thr Ser 
                485                 490                 495     


Ser Ala Asp Lys Thr Leu Ser Ile Trp Asp Ala Arg Thr Gly Ile Cys 
            500                 505                 510         


Glu Gln Ser Leu Tyr Gly His Met His Ser Ile Asn Asp Ala Ile Phe 
        515                 520                 525             


Asp Pro Arg Gly His Met Ile Ala Ser Cys Asp Ala Cys Gly Val Thr 
    530                 535                 540                 


Lys Leu Trp Asp Phe Arg Lys Leu Leu Pro Ile Val Ser Ile Asp Ile 
545                 550                 555                 560 


Gly Pro Ser Pro Gly Asn Glu Val Asn Phe Asp Ser Ser Gly Arg Val 
                565                 570                 575     


Leu Ala Gln Ala Ser Gly Asn Gly Val Ile His Leu Leu Asp Leu Lys 
            580                 585                 590         


Ser Gly Glu Ile His Lys Leu Met Gly His Glu Asn Glu Ala His Thr 
        595                 600                 605             


Val Val Phe Ser His Asp Gly Glu Ile Leu Phe Ser Gly Gly Ser Asp 
    610                 615                 620                 


Gly Thr Val Arg Thr Trp Ser 
625                 630     

<210>  122
<211>  6138
<212>  DNA
<213>  Homo sapiens

<400>  122
gctcgctcgg tctccggctc cggcgccggc tcctgctcct cctggccgcc cggggccaag     60

gcgacgagag gttgtaaaaa tccatgtggg acggccccgg ggcgagcatc ggaaagatct    120

ctgagtggag ttattttctg gtacggactg tgaaaagaat gcggtgaaaa ttctggacaa    180

tcgtggaaat attagctcaa accccaactt aatatagcat ttcttctctt cagtaacacc    240

tcataataca agaaaaatgt atggaagtgc aagaacaatc accaatctgg aaggtagccc    300

ttccagatcc cctcgtttgc caaggtctcc tcgtttgggc caccgaagaa caagtagtgg    360

gggaggtgga ggaacaggca agactctgtc tatggagaat atccagtccc tcaatgcagc    420

ctatgctacg tctggaccca tgtatctgag tgatcatgaa ggggtggctt caacaaccta    480

cccaaagggc actatgactc tgggaagggc tacaaatcga gctgtatatg gaggccgtgt    540

cacagccatg gggagtagtc ccaatattgc ttctgctgga ctttcccaca cagatgtcct    600

ttcatacaca gatcaacatg gtgggctgac tggctcatcc catcatcacc accaccaggt    660

cccctccatg ttgaggcagg taagagacag cacaatgtta gatcttcagg cccagctgaa    720

agaactgcag agagagaatg acctcctccg gaaagagcta gacatcaagg acagcaaatt    780

gggatcttcc atgaacagta ttaagacttt ctggagtcct gagcttaaga aggagagagt    840

cttgaggaaa gaagaggcag cgcggatgtc tgtcctcaag gagcagatga gggtttccca    900

tgaagaaaat cagcacctac agttgacaat ccaggccctt caagatgagc tgcgaaccca    960

gagagacctc aaccacctcc tccagcaaga gagtggcaac cgaggagcgg agcacttcac   1020

catcgagctg accgaggaga actttaggcg gctccaagcc gagcatgaca ggcaggctaa   1080

ggagctgttc cttttgagga agacattaga ggaaatggag ctgagaattg aaacgcagaa   1140

acaaaccctc aatgcccgag atgagtcaat taaaaaactt cttgagatgt tgcaaagtaa   1200

aggcttgcca tccaaaagcc tggaggatga caatgagcga acgcggcgga tggcagaggc   1260

tgagtctcag gtcagccact tggaagtgat tttagatcag aaagagaagg aaaacataca   1320

tcttagagag gaattgcacc gaagaagcca acttcagccg gagccagcca agacgaaggc   1380

tctccagact gtcatcgaaa tgaaggacac aaaaatcgct tcattggaac gaaacataag   1440

ggatcttgag gatgagatcc agatgttaaa agccaatggt gtgctgaaca ctgaggaccg   1500

cgaagaagag atcaaacaaa ttgaggttta caaaagtcac tccaagttta tgaagaccaa   1560

gattgatcag ctgaagcagg aactttcaaa gaaagagtcg gaacttcttg ccttacaaac   1620

aaagcttgaa accctcagca atcaaaattc agattgcaag caacacattg aagtgctcaa   1680

agagtcactt actgccaaag aacagagggc tgccatcctt cagactgagg tagatgcgct   1740

gagattacga ctggaagaaa aagaatcttt cctcaataaa aaaacaaaac agctacagga   1800

cctcacagaa gagaagggga cactggccgg tgaaattcgt gacatgaaag atatgttaga   1860

agtgaaggaa agaaaaatca atgttcttca gaaaaagatt gaaaacttgc aagaacaact   1920

tagggataaa gacaagcaac tgaccaacct gaaagacaga gtgaagtcct tgcagacgga   1980

ttccagtaat acagatactg cactggcgac gctagaggaa gctctgtcag agaaggagag   2040

aataattgag cgcttgaaag aacagcgaga aagagatgat cgggaaagac tagaagagat   2100

agaatccttc cgaaaagaga acaaagacct gaaagagaag gtcaatgctt tacaggctga   2160

actgactgag aaagagtcta gtttaattga cctcaaagaa catgcatctt cattagcctc   2220

tgcggggctg aaaagggatt ccaaattaaa atctctagaa atagccattg aacaaaagaa   2280

agaggaatgt agcaaattgg aagcacagtt aaaaaaggca cataatattg aagatgactc   2340

caggatgaac cctgagtttg cagaccaaat aaaacagctc gataaagagg cgtcttacta   2400

ccgcgacgag tgtggcaagg cccaagcgga agtggaccgg ttgctggaga tcctcaagga   2460

ggtggagaat gagaagaatg acaaggacaa gaagatcgca gaactggaga gcttgactct   2520

caggcatatg aaagatcaga ataagaaggt ggccaacctc aagcacaatc aacagttgga   2580

aaagaagaaa aatgctcagt tactagaaga agtgcgcagg cgagaagaca gcatggctga   2640

caactcacag catttgcaga tagaggaact gatgaatgca ctggagaaga ccagacagga   2700

actggatgcc accaaagcac gcctcgcctc cacacaacag tccctggccg aaaaagaagc   2760

gcacttggcc aacctccgga ttgagaggag gaaacagctg gaggagatcc tggagatgaa   2820

acaggaagca ctacttgcag ccatcagtga aaaagatgca aacattgcct tgctggaatt   2880

gtctgcctcc aaaaagaaaa agacgcagga agaagtcatg gccctcaagc gggaaaaaga   2940

ccgactagta catcaattaa agcagcagac ccagaacaga atgaagttga tggcagacaa   3000

ctatgatgat gaccatcacc attaccacca ccaccaccat caccaccacc atcgatctcc   3060

tgggaggtcg caacattcca atcacaggcc ctctccggac caggatgacg aggagggcat   3120

atgggcatag ccgggcctgt aaaccaaagt tccagttttg ttttgagggc tattagaagg   3180

gctgaataaa gggaacatgc agctctgcag caatattctg ataatgtatt gcagtgcggc   3240

tcacatcact gtccaccacc acctggagcg gctcatcaga actgaagggg agttttcact   3300

taccttattg agcgtgattc tgttctactt gatatttcct tcaccacctc atgtcatttc   3360

tcatggattt ggttatgatg gaaaggaaga atgcagagga ggagaaaagt gacagatcct   3420

ccatttttgt tgggatgcgg gcattttgaa tgtgatcatc tttgctgaat gtcattattt   3480

gataacattt tgtttatgtt acttaaacat cattggataa atttgaactc catgggattt   3540

tatctgtgga ttcagcttct gttggacaac tagcctcatc tccagtatcc tgctggttca   3600

ctctaattgg tcattcctaa tgcattagat tatcaaaaag tataaattcg ctgtgagtga   3660

gtggtgttgg cagtgtttgt ataccatgat gcatggagtg tttgacgaag aaacaaaaaa   3720

caccaaaaat tgcgagcctt taccctcctc tatttcttta atctgttgtt tgaagaaccg   3780

cattttgagg gtgtaaccag tagtcacctc tgggccaggt tggaaaagaa atcaattttt   3840

taaaccacta atgcttgcca agaaatcgcc ttatgagaac atggtgtgtg tctctgacaa   3900

tgcgtggcac atctaaattg atcattcata attttatcta cccagtcatg tactggagag   3960

tggcaaaagt ctgaggcacc tgcatatctc tagtccctgt gttctgcaca tccccacggt   4020

ggggacgcca ccaagcctca gactcttacc atcccggtgc atgcaggtct ccatgaagaa   4080

gctgggactc attcacattt caagatccaa atgctgtgca aacagtgtaa gcttagattt   4140

tctgtaaatg aagggtcatt tctctttttt ttttttttta aagaaaatgt gtctgcaaca   4200

tggattccaa agcattttca gcatcaaaca tgaaaacatt gatgaatgag gaacaatcac   4260

aaaagctgtg tctctgtata tagctctaca caacatgtat gtggatacag tcattattta   4320

aagcacatgc cagggaaaaa gaccaaattt tgaggtcttt tacatacagt gatatggtac   4380

taaggagaat taaactccta ctgcttcctc tgaatattaa gaaacaattt aaattgttat   4440

aacttcataa aactcatgac tgagtctggc aaacatgtgc aactcttgta ttgctccatt   4500

ttcttgtcaa tggaagaaac ccttccacgt gtatgcaagt gggagatgaa aacctgcatt   4560

tttaaaggac aaacagtgaa tttaagcatg agtggcctta ataaatatag ttgtctttct   4620

ttgctgctgt ggaaaggatt ctaaacagat gtccctgaag tcttgcattg aatttagtca   4680

ttattattac tttttaaaat gttggtgcaa ttaactctgg acctctcttg tgagccatag   4740

agatatttaa aagacaaaca ccttatttgt cggggaagat gaaaccgtcc ctgagttgca   4800

ccattctttc ttggtgcatt cgcggttaag atactcaagc aggtttcttg cttctggctt   4860

tgttcttgtc atcagtaagt ataacaaact atgtaatgct tatgtgttgc ataaacaatc   4920

caaatgcatt catgttttaa aagtttgtcc tttaactatc agagggatct aggtcttggt   4980

tagagaagta agcagagttc tttgcaagct tatttagcac attttgacac aatgttgcac   5040

tgaaaaccca ggccacaaat gtgtcccagt gaacagtttg gatgtcctca aagaagtggt   5100

tctcactgcc tcctacaacc aggtcttgac ctgaactctg caactgaata cttgaagtag   5160

gaagtaggaa atccagtagg gaaaataggg tccttgaaac agaaaaaaaa aaccaaccca   5220

tgtatagcta gctatttcta tgtatgtgcc aattttgtca cagctcttgt ttggagggat   5280

cattttctgc ccaactttca ttggttaaaa tattactgat cttaccttta tgaggtcgta   5340

taatttagtc ccttaaaaat taaattctct ctaacataac aacctttccc atttcgtgta   5400

atattctctg atgtttgggg gttaccaaaa atatcccttt ttcacatatt aagaatagtc   5460

tctgggttta caacaaacac tgtgatgttg ggaagctatt tcctttgcgc aaactttaac   5520

aggttttctt ctaatcataa catagttgaa aaaagaagtt tgggctaaca tttaggagaa   5580

gttggtctta ctttgtgcaa aagcaggctt gtgctttata ccccatttga tttcgatgta   5640

cagtctcaat tttgtattta atgatttttg tgtatccagt atgcacgtta acagcgtgtc   5700

aactttcatt tgaaagtggg tttcaattta ctttttaaac agtgtttatg acgagacctc   5760

agatgtgttg acgtaagctc tatctgcaat gtttttgtgt agagtggcga ttgaatgctg   5820

cccagggtca gtgtatctaa ttccccgaga ccctcgtttg atagtgcttc ttgtaatatt   5880

tcttcaagtg agtggcatgt gggttgtgat attgaccatg tgattatgga catcgatatg   5940

aaaaataaat aaataaaact aaggaaccct ggaaactacc agtgggcatg tattagccag   6000

tcattgtaac ctcgtgtcta gtagaacaat gtacaaggta tgtacagttc ataaatttgt   6060

tgtcatgtgt atgagaagta ctttgtgctg atcgccttat ttatattcat caaataaacc   6120

ttgtttcttt ctgaagtg                                                 6138


<210>  123
<211>  957
<212>  PRT
<213>  Homo sapiens

<400>  123


Met Tyr Gly Ser Ala Arg Thr Ile Thr Asn Leu Glu Gly Ser Pro Ser 
1               5                   10                  15      


Arg Ser Pro Arg Leu Pro Arg Ser Pro Arg Leu Gly His Arg Arg Thr 
            20                  25                  30          


Ser Ser Gly Gly Gly Gly Gly Thr Gly Lys Thr Leu Ser Met Glu Asn 
        35                  40                  45              


Ile Gln Ser Leu Asn Ala Ala Tyr Ala Thr Ser Gly Pro Met Tyr Leu 
    50                  55                  60                  


Ser Asp His Glu Gly Val Ala Ser Thr Thr Tyr Pro Lys Gly Thr Met 
65                  70                  75                  80  


Thr Leu Gly Arg Ala Thr Asn Arg Ala Val Tyr Gly Gly Arg Val Thr 
                85                  90                  95      


Ala Met Gly Ser Ser Pro Asn Ile Ala Ser Ala Gly Leu Ser His Thr 
            100                 105                 110         


Asp Val Leu Ser Tyr Thr Asp Gln His Gly Gly Leu Thr Gly Ser Ser 
        115                 120                 125             


His His His His His Gln Val Pro Ser Met Leu Arg Gln Val Arg Asp 
    130                 135                 140                 


Ser Thr Met Leu Asp Leu Gln Ala Gln Leu Lys Glu Leu Gln Arg Glu 
145                 150                 155                 160 


Asn Asp Leu Leu Arg Lys Glu Leu Asp Ile Lys Asp Ser Lys Leu Gly 
                165                 170                 175     


Ser Ser Met Asn Ser Ile Lys Thr Phe Trp Ser Pro Glu Leu Lys Lys 
            180                 185                 190         


Glu Arg Val Leu Arg Lys Glu Glu Ala Ala Arg Met Ser Val Leu Lys 
        195                 200                 205             


Glu Gln Met Arg Val Ser His Glu Glu Asn Gln His Leu Gln Leu Thr 
    210                 215                 220                 


Ile Gln Ala Leu Gln Asp Glu Leu Arg Thr Gln Arg Asp Leu Asn His 
225                 230                 235                 240 


Leu Leu Gln Gln Glu Ser Gly Asn Arg Gly Ala Glu His Phe Thr Ile 
                245                 250                 255     


Glu Leu Thr Glu Glu Asn Phe Arg Arg Leu Gln Ala Glu His Asp Arg 
            260                 265                 270         


Gln Ala Lys Glu Leu Phe Leu Leu Arg Lys Thr Leu Glu Glu Met Glu 
        275                 280                 285             


Leu Arg Ile Glu Thr Gln Lys Gln Thr Leu Asn Ala Arg Asp Glu Ser 
    290                 295                 300                 


Ile Lys Lys Leu Leu Glu Met Leu Gln Ser Lys Gly Leu Pro Ser Lys 
305                 310                 315                 320 


Ser Leu Glu Asp Asp Asn Glu Arg Thr Arg Arg Met Ala Glu Ala Glu 
                325                 330                 335     


Ser Gln Val Ser His Leu Glu Val Ile Leu Asp Gln Lys Glu Lys Glu 
            340                 345                 350         


Asn Ile His Leu Arg Glu Glu Leu His Arg Arg Ser Gln Leu Gln Pro 
        355                 360                 365             


Glu Pro Ala Lys Thr Lys Ala Leu Gln Thr Val Ile Glu Met Lys Asp 
    370                 375                 380                 


Thr Lys Ile Ala Ser Leu Glu Arg Asn Ile Arg Asp Leu Glu Asp Glu 
385                 390                 395                 400 


Ile Gln Met Leu Lys Ala Asn Gly Val Leu Asn Thr Glu Asp Arg Glu 
                405                 410                 415     


Glu Glu Ile Lys Gln Ile Glu Val Tyr Lys Ser His Ser Lys Phe Met 
            420                 425                 430         


Lys Thr Lys Ile Asp Gln Leu Lys Gln Glu Leu Ser Lys Lys Glu Ser 
        435                 440                 445             


Glu Leu Leu Ala Leu Gln Thr Lys Leu Glu Thr Leu Ser Asn Gln Asn 
    450                 455                 460                 


Ser Asp Cys Lys Gln His Ile Glu Val Leu Lys Glu Ser Leu Thr Ala 
465                 470                 475                 480 


Lys Glu Gln Arg Ala Ala Ile Leu Gln Thr Glu Val Asp Ala Leu Arg 
                485                 490                 495     


Leu Arg Leu Glu Glu Lys Glu Ser Phe Leu Asn Lys Lys Thr Lys Gln 
            500                 505                 510         


Leu Gln Asp Leu Thr Glu Glu Lys Gly Thr Leu Ala Gly Glu Ile Arg 
        515                 520                 525             


Asp Met Lys Asp Met Leu Glu Val Lys Glu Arg Lys Ile Asn Val Leu 
    530                 535                 540                 


Gln Lys Lys Ile Glu Asn Leu Gln Glu Gln Leu Arg Asp Lys Asp Lys 
545                 550                 555                 560 


Gln Leu Thr Asn Leu Lys Asp Arg Val Lys Ser Leu Gln Thr Asp Ser 
                565                 570                 575     


Ser Asn Thr Asp Thr Ala Leu Ala Thr Leu Glu Glu Ala Leu Ser Glu 
            580                 585                 590         


Lys Glu Arg Ile Ile Glu Arg Leu Lys Glu Gln Arg Glu Arg Asp Asp 
        595                 600                 605             


Arg Glu Arg Leu Glu Glu Ile Glu Ser Phe Arg Lys Glu Asn Lys Asp 
    610                 615                 620                 


Leu Lys Glu Lys Val Asn Ala Leu Gln Ala Glu Leu Thr Glu Lys Glu 
625                 630                 635                 640 


Ser Ser Leu Ile Asp Leu Lys Glu His Ala Ser Ser Leu Ala Ser Ala 
                645                 650                 655     


Gly Leu Lys Arg Asp Ser Lys Leu Lys Ser Leu Glu Ile Ala Ile Glu 
            660                 665                 670         


Gln Lys Lys Glu Glu Cys Ser Lys Leu Glu Ala Gln Leu Lys Lys Ala 
        675                 680                 685             


His Asn Ile Glu Asp Asp Ser Arg Met Asn Pro Glu Phe Ala Asp Gln 
    690                 695                 700                 


Ile Lys Gln Leu Asp Lys Glu Ala Ser Tyr Tyr Arg Asp Glu Cys Gly 
705                 710                 715                 720 


Lys Ala Gln Ala Glu Val Asp Arg Leu Leu Glu Ile Leu Lys Glu Val 
                725                 730                 735     


Glu Asn Glu Lys Asn Asp Lys Asp Lys Lys Ile Ala Glu Leu Glu Ser 
            740                 745                 750         


Leu Thr Leu Arg His Met Lys Asp Gln Asn Lys Lys Val Ala Asn Leu 
        755                 760                 765             


Lys His Asn Gln Gln Leu Glu Lys Lys Lys Asn Ala Gln Leu Leu Glu 
    770                 775                 780                 


Glu Val Arg Arg Arg Glu Asp Ser Met Ala Asp Asn Ser Gln His Leu 
785                 790                 795                 800 


Gln Ile Glu Glu Leu Met Asn Ala Leu Glu Lys Thr Arg Gln Glu Leu 
                805                 810                 815     


Asp Ala Thr Lys Ala Arg Leu Ala Ser Thr Gln Gln Ser Leu Ala Glu 
            820                 825                 830         


Lys Glu Ala His Leu Ala Asn Leu Arg Ile Glu Arg Arg Lys Gln Leu 
        835                 840                 845             


Glu Glu Ile Leu Glu Met Lys Gln Glu Ala Leu Leu Ala Ala Ile Ser 
    850                 855                 860                 


Glu Lys Asp Ala Asn Ile Ala Leu Leu Glu Leu Ser Ala Ser Lys Lys 
865                 870                 875                 880 


Lys Lys Thr Gln Glu Glu Val Met Ala Leu Lys Arg Glu Lys Asp Arg 
                885                 890                 895     


Leu Val His Gln Leu Lys Gln Gln Thr Gln Asn Arg Met Lys Leu Met 
            900                 905                 910         


Ala Asp Asn Tyr Asp Asp Asp His His His Tyr His His His His His 
        915                 920                 925             


His His His His Arg Ser Pro Gly Arg Ser Gln His Ser Asn His Arg 
    930                 935                 940                 


Pro Ser Pro Asp Gln Asp Asp Glu Glu Gly Ile Trp Ala 
945                 950                 955         

<210>  124
<211>  3115
<212>  DNA
<213>  Homo sapiens

<400>  124
gtagcgcttg ctgagcggcg gcggcaaccg acgtacacaa ggggcttgag cgttctgtgg     60

agagagtgcg agagatggtt taaagcttga aactgaatta ctggatggaa aaaccaagct    120

aatattgtct ccatatgaac ataaatcaaa aatttctgtg aagatgggaa ataaggccaa    180

gattgcaaaa tgtcctttaa gaacaaaaac tgggcacatt ctaaaatcaa cacaagatac    240

ttgtattggg agtgaaaaac ttttgcaaaa gaagccagtt ggttcagaaa catcacaggc    300

aaaaggtgaa aaaaatggaa tgactttttc atccactaag gatttatgta aacaatgtat    360

agataaagac tgtcttcata tccagaaaga gatttcacct gcaaccccta atatgcagaa    420

gactagaaac accgtaaata catctctagt aggtaaacag aagcctcaca aaaaacacat    480

cacagctgaa aacatgaaga gcagtttggt gtgtctaaca caagaccaac tacaacagat    540

tttgatgact gtaaaccaag gaaatagatc tctttccctg actgagaatg gaaaggaggc    600

aaaaagtcaa tatagtctat atttaaacag tatttctaat cagccaaagg atgagaacat    660

tatgggatta ttcaaaaaaa ctgaaatggt ttcatctgtc ccagctgaaa ataaatctgt    720

cttaaatgaa catcaggaga catctaaaca gtgtgagcaa aaaattgcca tagagaatga    780

atggaaacca gctgatatat tcagtactct gggggaaagg gaatgtgata gaagttcgtt    840

ggaagcaaaa aaagcccagt ggaggaaaga gctagatgaa caggttgctt taaagaagaa    900

agaaaaagaa gtttctgaaa aatggaatga tccttggaaa aaatctgaaa gtgataaaat    960

aatatgggaa aaacatcaaa ttcttgacca atctagggaa acagtactgc tggagcaccc   1020

tttcagtgct gtgaaacaag aactgcaaag aaaatggatt gaagagttga ataagcaaat   1080

agaagatgac cgtcaaagaa aaatagagga aaaaattata tattcaaagg gtgaggaaca   1140

tgacagatgg gcaatgcact ttgattcatt aaagagttat cctggttctc aatctcagct   1200

gttctctcag tcaacacaca aacaacctga gtacttctgt gtctctcctg acactcagga   1260

gctggctgat gtcagcagtg tttgtacacc tacaaccgga agccaggttg aaccttcaga   1320

ggaggagcat atagcaaaac ctattaagga tgtggttatg gcaaacagta agaaaacaaa   1380

ctttctccgt tctatgactg ctctcttgga cccagctcag attgaggaac gagacagacg   1440

acgacaaaaa caattagagc atcagaaagc catcactgcc caggtagaag agaagcgcag   1500

gaagaaacaa ctggaggaag agcaaagaaa gaaggaagaa caagaagagg agcttcgctt   1560

agcacaggaa cgtgaagaga tgcagaaaca gtatgaagaa gacatactta agcaaaaaca   1620

aaaggaagaa atcatgactc tcaagacaaa tgagctattc cagacaatgc agcgagcaca   1680

ggaactggca cagagactaa aacaagaaca aagaatccga gaattggcgc aaaagggaca   1740

tgacacttct agactgatta aaaatcttgg tgttgataca atacaaatgg aatataatgc   1800

atctaacatt tcaaattcaa gacatgattc tgatgaaatc agtggtaaaa tgaatacata   1860

tatgaattct acgacttcta agaaggatac tggtgtgcaa acagatgact taaatatagg   1920

aatattcacc aatgcagaat cacattgtgg atcattaatg gagagggaca tcacaaattg   1980

ttcatctcct gagatttcgg cagaacttat tggacagttt agcaccaaga aaaacaagca   2040

agaactaact caggataaag gagccagctt agaaaaagaa aacaatcggt gtaatgacca   2100

gtgtaatcag ttcacaagaa tagagaaaca aacaaaacac atgaagaaat atcctaaaag   2160

gcctgattgg aatataaata agccacctaa aaggtatatt ccagcatcag aaaagtaccc   2220

taaacagctt caaaagcaga gagaagaaaa aaaagtaagg aggcagatgg aattgcttca   2280

tttggtagaa aaaaataatc ctgggcacct ctctcaaaac agaggcattt caccagaaat   2340

ttttcattca tctcatcaag aaacggagtc aaagttgagg tggcatctag tcaaaaagga   2400

agaagagcct ctgaatattc attcattcag caaggaaagg tctccatcat caccagttcc   2460

agtagtgaaa aacagaaccc aacaaactca aaatacatta catttaccac taaaaaacag   2520

tagctatgag agagagaatt tgatctcagg aagtaatcaa acagaattat catctgggat   2580

ttctgaatca tcccatttta ttccgtatgt tcgaacaaat gagatctatt accttgatcc   2640

cgatgcacca ttgtctgggc cttcaaccca ggaccctcag taccaaaatt cacaagactg   2700

tggccaaaaa cgacagctat ttgattctga ctgtgtcagg gatccacttc ttaatcctaa   2760

catggtgaaa aatagggatc gacagcaagc aatccttaag ggactttcag aactgagaca   2820

gggccttctc cagaagcaaa aggagttgga aagtagtctc ctgcctttag ctgaaaatca   2880

agaagagagt tttggttctt cattttaaat gtagaaaatc aaatccttca catttgattt   2940

gtgtcttcca aattataaaa tgtgctcact ggctcaactg tatttttcaa atagcctaga   3000

tttacttatt tttttaaatg ctcattaaaa acttgtatac tatgtagtaa aatgctgtac   3060

ttgttctata caataaaaca gatacttctt ttgtaaaagc ttagtagtaa aaaaa        3115


<210>  125
<211>  914
<212>  PRT
<213>  Homo sapiens

<400>  125


Met Gly Asn Lys Ala Lys Ile Ala Lys Cys Pro Leu Arg Thr Lys Thr 
1               5                   10                  15      


Gly His Ile Leu Lys Ser Thr Gln Asp Thr Cys Ile Gly Ser Glu Lys 
            20                  25                  30          


Leu Leu Gln Lys Lys Pro Val Gly Ser Glu Thr Ser Gln Ala Lys Gly 
        35                  40                  45              


Glu Lys Asn Gly Met Thr Phe Ser Ser Thr Lys Asp Leu Cys Lys Gln 
    50                  55                  60                  


Cys Ile Asp Lys Asp Cys Leu His Ile Gln Lys Glu Ile Ser Pro Ala 
65                  70                  75                  80  


Thr Pro Asn Met Gln Lys Thr Arg Asn Thr Val Asn Thr Ser Leu Val 
                85                  90                  95      


Gly Lys Gln Lys Pro His Lys Lys His Ile Thr Ala Glu Asn Met Lys 
            100                 105                 110         


Ser Ser Leu Val Cys Leu Thr Gln Asp Gln Leu Gln Gln Ile Leu Met 
        115                 120                 125             


Thr Val Asn Gln Gly Asn Arg Ser Leu Ser Leu Thr Glu Asn Gly Lys 
    130                 135                 140                 


Glu Ala Lys Ser Gln Tyr Ser Leu Tyr Leu Asn Ser Ile Ser Asn Gln 
145                 150                 155                 160 


Pro Lys Asp Glu Asn Ile Met Gly Leu Phe Lys Lys Thr Glu Met Val 
                165                 170                 175     


Ser Ser Val Pro Ala Glu Asn Lys Ser Val Leu Asn Glu His Gln Glu 
            180                 185                 190         


Thr Ser Lys Gln Cys Glu Gln Lys Ile Ala Ile Glu Asn Glu Trp Lys 
        195                 200                 205             


Pro Ala Asp Ile Phe Ser Thr Leu Gly Glu Arg Glu Cys Asp Arg Ser 
    210                 215                 220                 


Ser Leu Glu Ala Lys Lys Ala Gln Trp Arg Lys Glu Leu Asp Glu Gln 
225                 230                 235                 240 


Val Ala Leu Lys Lys Lys Glu Lys Glu Val Ser Glu Lys Trp Asn Asp 
                245                 250                 255     


Pro Trp Lys Lys Ser Glu Ser Asp Lys Ile Ile Trp Glu Lys His Gln 
            260                 265                 270         


Ile Leu Asp Gln Ser Arg Glu Thr Val Leu Leu Glu His Pro Phe Ser 
        275                 280                 285             


Ala Val Lys Gln Glu Leu Gln Arg Lys Trp Ile Glu Glu Leu Asn Lys 
    290                 295                 300                 


Gln Ile Glu Asp Asp Arg Gln Arg Lys Ile Glu Glu Lys Ile Ile Tyr 
305                 310                 315                 320 


Ser Lys Gly Glu Glu His Asp Arg Trp Ala Met His Phe Asp Ser Leu 
                325                 330                 335     


Lys Ser Tyr Pro Gly Ser Gln Ser Gln Leu Phe Ser Gln Ser Thr His 
            340                 345                 350         


Lys Gln Pro Glu Tyr Phe Cys Val Ser Pro Asp Thr Gln Glu Leu Ala 
        355                 360                 365             


Asp Val Ser Ser Val Cys Thr Pro Thr Thr Gly Ser Gln Val Glu Pro 
    370                 375                 380                 


Ser Glu Glu Glu His Ile Ala Lys Pro Ile Lys Asp Val Val Met Ala 
385                 390                 395                 400 


Asn Ser Lys Lys Thr Asn Phe Leu Arg Ser Met Thr Ala Leu Leu Asp 
                405                 410                 415     


Pro Ala Gln Ile Glu Glu Arg Asp Arg Arg Arg Gln Lys Gln Leu Glu 
            420                 425                 430         


His Gln Lys Ala Ile Thr Ala Gln Val Glu Glu Lys Arg Arg Lys Lys 
        435                 440                 445             


Gln Leu Glu Glu Glu Gln Arg Lys Lys Glu Glu Gln Glu Glu Glu Leu 
    450                 455                 460                 


Arg Leu Ala Gln Glu Arg Glu Glu Met Gln Lys Gln Tyr Glu Glu Asp 
465                 470                 475                 480 


Ile Leu Lys Gln Lys Gln Lys Glu Glu Ile Met Thr Leu Lys Thr Asn 
                485                 490                 495     


Glu Leu Phe Gln Thr Met Gln Arg Ala Gln Glu Leu Ala Gln Arg Leu 
            500                 505                 510         


Lys Gln Glu Gln Arg Ile Arg Glu Leu Ala Gln Lys Gly His Asp Thr 
        515                 520                 525             


Ser Arg Leu Ile Lys Asn Leu Gly Val Asp Thr Ile Gln Met Glu Tyr 
    530                 535                 540                 


Asn Ala Ser Asn Ile Ser Asn Ser Arg His Asp Ser Asp Glu Ile Ser 
545                 550                 555                 560 


Gly Lys Met Asn Thr Tyr Met Asn Ser Thr Thr Ser Lys Lys Asp Thr 
                565                 570                 575     


Gly Val Gln Thr Asp Asp Leu Asn Ile Gly Ile Phe Thr Asn Ala Glu 
            580                 585                 590         


Ser His Cys Gly Ser Leu Met Glu Arg Asp Ile Thr Asn Cys Ser Ser 
        595                 600                 605             


Pro Glu Ile Ser Ala Glu Leu Ile Gly Gln Phe Ser Thr Lys Lys Asn 
    610                 615                 620                 


Lys Gln Glu Leu Thr Gln Asp Lys Gly Ala Ser Leu Glu Lys Glu Asn 
625                 630                 635                 640 


Asn Arg Cys Asn Asp Gln Cys Asn Gln Phe Thr Arg Ile Glu Lys Gln 
                645                 650                 655     


Thr Lys His Met Lys Lys Tyr Pro Lys Arg Pro Asp Trp Asn Ile Asn 
            660                 665                 670         


Lys Pro Pro Lys Arg Tyr Ile Pro Ala Ser Glu Lys Tyr Pro Lys Gln 
        675                 680                 685             


Leu Gln Lys Gln Arg Glu Glu Lys Lys Val Arg Arg Gln Met Glu Leu 
    690                 695                 700                 


Leu His Leu Val Glu Lys Asn Asn Pro Gly His Leu Ser Gln Asn Arg 
705                 710                 715                 720 


Gly Ile Ser Pro Glu Ile Phe His Ser Ser His Gln Glu Thr Glu Ser 
                725                 730                 735     


Lys Leu Arg Trp His Leu Val Lys Lys Glu Glu Glu Pro Leu Asn Ile 
            740                 745                 750         


His Ser Phe Ser Lys Glu Arg Ser Pro Ser Ser Pro Val Pro Val Val 
        755                 760                 765             


Lys Asn Arg Thr Gln Gln Thr Gln Asn Thr Leu His Leu Pro Leu Lys 
    770                 775                 780                 


Asn Ser Ser Tyr Glu Arg Glu Asn Leu Ile Ser Gly Ser Asn Gln Thr 
785                 790                 795                 800 


Glu Leu Ser Ser Gly Ile Ser Glu Ser Ser His Phe Ile Pro Tyr Val 
                805                 810                 815     


Arg Thr Asn Glu Ile Tyr Tyr Leu Asp Pro Asp Ala Pro Leu Ser Gly 
            820                 825                 830         


Pro Ser Thr Gln Asp Pro Gln Tyr Gln Asn Ser Gln Asp Cys Gly Gln 
        835                 840                 845             


Lys Arg Gln Leu Phe Asp Ser Asp Cys Val Arg Asp Pro Leu Leu Asn 
    850                 855                 860                 


Pro Asn Met Val Lys Asn Arg Asp Arg Gln Gln Ala Ile Leu Lys Gly 
865                 870                 875                 880 


Leu Ser Glu Leu Arg Gln Gly Leu Leu Gln Lys Gln Lys Glu Leu Glu 
                885                 890                 895     


Ser Ser Leu Leu Pro Leu Ala Glu Asn Gln Glu Glu Ser Phe Gly Ser 
            900                 905                 910         


Ser Phe 
        

<210>  126
<211>  7247
<212>  DNA
<213>  Homo sapiens

<400>  126
atatatcatt gttttctgtc ttcctcatta gatttatgta ggttggaact ttgttctgtt     60

tatctctata atcctattac ctagaactgt gcctggtaaa taagagctta gtatgtattt    120

actgaatgat gaattaatat atttatatat tgaggctgtg tcttctaatg tcagcaaaat    180

aattgacaag agactttggt ggacactgtt ctctcttggt taatattttt ggaaaaaaca    240

actcccttaa atttgggtaa atgtggtaat ttgagcgaag taagtacttc tgttttctct    300

aagtagactt ggatttacta gactttgtaa tgagtaattt ctttgttctt cctacctgga    360

ggaaggactt aactgtagta tgccattaaa aattgcactt atatcatctt acatgttaat    420

ttttatgatt atactaatga gtaatgtttt tcttttcttt taaaaaattt gtagatctaa    480

cagctttaat acagatagaa acatagataa atataactat accttgtgga aaggacagct    540

tttaaataaa ggaaaacttt tgtgttatat ttctctgagg tcagccactc gtgctttttt    600

gcctatcaaa ctacctgaga aattagatgt tgaaacagtt atgagtattg atcatctgaa    660

acagaaaatc cctccagcac tgttttataa ggaaacatac ttaggtccaa atgaagtttt    720

gaagaatgga atgtattgca gcctttatga agttgtggaa aagacaagaa ttggaagtaa    780

catggagagt ttactgcaaa aactagacag agaaaaactt gttcttgtta aacctttggg    840

agaccgagga tacctttttc ttctctcccc ttatcagatg gttcctccat atgaatatca    900

gactgccaag tctcgagtcc tacatgcttt gtttctattt caagaaccta gaagcatagt    960

tacttcacaa aaaggttcaa ccaatgcagc accacaggag aggcatgaga gcatgccaga   1020

tgtattaaaa atagctcagt ttttacaatt ttctttgatt cagtgtcgaa aggaattcaa   1080

aaatataagc gccataaatt ttcattctgt tgttgaaaag tatgtaagtg aattttttaa   1140

gcgaggtttt ggttcaggta aacgagagtt tattatgttt ccatatgatt cacgattaga   1200

tgataaaaaa ttcttatact cagctcccag aaataaatcc catattgata cttgtttgca   1260

tgcctatatt tttcggcctg aagtgtatca gttacctatt tgtaaattaa aagaactatt   1320

tgaagaaaat agaaaacttc agcagtttag tccactttca gattatgaag gtcaagaaga   1380

agaaatgaat ggtacaaaaa tgaaatttgg aaaacgaaat aactcaagag gtgaagccat   1440

tatatctgga aagcaaagat catctcattc tttggattat gataaggata gagtcaaaga   1500

attgattaat ttaattcagt gtaggaaaaa gagtgtgggt ggggactcag acacagaaga   1560

tatgagaagc aaaactgtct tgaagaggaa gcttgaggat ctacctgaaa atatgagaaa   1620

gctcgccaaa accagtaatt tatctgaaaa ttgccatctg tatgaagagt ctccacagcc   1680

tattggctca cttggacatg atgctgactt gaggcggcag cagcaggata cctgtaactc   1740

cggcattgct gacatccata ggctgtttaa ttggttatca gaaacactag caaatgcgcg   1800

ccattctgat gcatctctga cagacacagt caacaaagcc ttaggattga gcactgatga   1860

tgcctatgaa gagctgaggc aaaaacatga gtatgagttg aactctaccc cagataagaa   1920

agactatgag cagcctactt gtgcaaaagt tgaaaatgca cagtttaagg gtactcagag   1980

cttattacta gaagttgatg caacatctaa gtattctgtt gctatttcta ccagcgaagt   2040

gggcactgac cataagctac atttgaaaga agatccaaat ttaattagcg tgaataattt   2100

tgaagattgc agtttgtgtc ccagtgttcc cattgaacat ggatttcgta gacaacagtc   2160

taagtcaaat aatgttgaag agactgaaat acattggaaa ctgattccaa ttacaggagg   2220

gaatgcaaga agcccagaag accagctggg gaaacatggt gagaaacaaa caccagacac   2280

actaaagggc accactgagg atgacgtgtt gacaggtcag gtggaggagc agtgtgtgcc   2340

agcagcagag gcagagccgc ctgcagtgag cgaaaccaca gagaggacag tgttaggaga   2400

gtacaatctc ttttctagga agatagaaga gattttgaag caaaagaatg tttcatatgt   2460

cagtacagtt tccacaccta tcttttcaac acaagagaag atgaaacggc tttccgagtt   2520

catatattct aagacttcca aagctggtgt gcaggagttt gtagatggtt tgcatgagaa   2580

gctaaatact attattatta aagcatcagc caagggtggg aatttgccac cagtcagtcc   2640

taacgattct ggtgctaaga tagcatcgaa tcctctggaa aggcatgtca taccagtttc   2700

ctcaagtgac ttcaacaata aacatctcct tgagccactg tgtagtgatc ctttgaaaga   2760

taccaactct gatgagcagc attccacttc ggctttaact gaagtagaaa tgaaccagcc   2820

tcaacatgcc acagagttaa tggtgacttc tgatcatatt gtacctggtg atatggcccg   2880

ggaaccagta gaagaaacaa caaaatcccc cagtgatgta aacatttctg ctcaaccagc   2940

tctttcaaat tttataagcc agttagaacc tgaagtattt aatagtttgg ttaaaatcat   3000

gaaagacgtc cagaaaaata ctgtgaaatt ttatattcat gaagaagaag agagtgtgct   3060

ctgtaaagaa ataaaggaat atcttatcaa attaggcaat acagaatgtc atcctgaaca   3120

gtttttggaa agaagatcaa aattagataa actattgatt attattcaaa atgaagacat   3180

tgcaggtttc attcacaaga tacctggctt ggtgacttta aagaagctcc cctgtgttag   3240

ttttgctggt gttgatagcc tggatgatgt taaaaatcat acatacaatg aattatttgt   3300

atctggaggt tttatcgtat ctgatgaatc aattctaaac ccagaggttg tcacagttga   3360

gaaccttaaa aattttttga cattccttga ggaacttagt actccagaag gaaaatggca   3420

atggaaagtc cactgtaaat ttcagaagaa actaaaggaa ctaggcagat tgaatgctaa   3480

agctctaagt ctgttgacgc ttctgaatgt ctatcagaag aaacatctgg ttgaaatttt   3540

gtcataccac aattgtgatt cacaaactcg aaatgctcca gaattggatt gccttatcag   3600

acttcaggct cagaacatac agcaacgaca catagtcttt ttaacagaga agaacatcaa   3660

gatgctttcc agttatacag ataatggaat agtggttgca actgctgaag acttcatgca   3720

aaactttaaa aatcttgtgg gctatcacaa ttcaatcaca gaagaaaacc ttccacagct   3780

tggtgctaat gagaatcttg agtcgcagtc agctctttta gaaaacgatg aaaaggatga   3840

agaggatatg tctctggatt caggggatga aatctcacat atagaagtat gcagcaattt   3900

tcattcagaa atatgggaga aagagaccaa aggatcacgt ggaacagatc aaaaaaagaa   3960

tactcaaatt gagttgcaat cgtctcctga tgtgcaaaac agtttattag aagataagac   4020

ttaccttgat tctgaagaga gaacttctat tgatatagta tgctctgaag gagagaacag   4080

caattcaaca gaacaagatt catatagtaa ctttcaggtt tatcatagtc aattaaatat   4140

gtcccatcag tttagtcatt ttaatgttct cactcatcag acatttttgg ggacaccata   4200

tgccctttca tcaagtcagt ctcaagaaaa tgagaattac ttcttatctg cttatactga   4260

aagcttggat agagataaat ctccacctcc cttaagttgg gggaaaagtg attcttccag   4320

gccatattca caagagaaat aactgtagta actttttttt taagagattg ttgtggactt   4380

tgtttattaa caatttatat ttcattctct aaacaaaagg ttcttgttct ttctcaaatg   4440

ttttttcttt tatttaaatc atgatggcct gtaacagttg aagcatctaa aaattgaaat   4500

aaatatatat ttttaacata tattgtactt gaattatctc atgttggcac ttctaagttt   4560

tactttttgt atgttacctg tacttaggct tcaaattgaa gcctgtttta tgtgtaaaat   4620

cagatgcttg caggaggacg gtaaacagca aaggctttac ttctttttct ctaatgtcac   4680

ctgatataaa gtacttttgt tgaagtgaat tattttgatg taggcttttg tatactgtgt   4740

ttacacaggt ataagtcagt aatagcagtg ttaatattta caggattttg gctcgatacc   4800

tcaagattta tctaacagtg cagtttcatt tagataataa actatgtaca taggacacat   4860

tttttatctc taggcttagt catgtaaaaa ctgcctattg ctaaaattct ggtaactttt   4920

tgagagtatt ggataatttt cagtacctgc gcaatccttg atttaatgaa attaaatttt   4980

ttatttcaaa agataggctt ctgtttatca aaggcgttga acaatttgat ttttaaatta   5040

gttttagcaa aatggaagta taatgggaat atatttttga ggtggtctta gtagtaatta   5100

ccatttgttg aacacattaa tgctatacta gacagataca gtggagatag ctttcaaacc   5160

cgtatctatt cctaactact gcctctaata ctaattacta acttgttact aatgctaact   5220

tttaaaaatg tttttgaaaa ttgcaatttc tacaaataaa tgtcatagtg caaataaatg   5280

tcaggattta gagaaggagc ctaaactgaa tttgtgttat ttcagtaaaa gttatggagt   5340

tatgggtcta gacgtgttaa taagttagac agaactttgg cactttagaa caaatgcatg   5400

agtggtattt cagttcctaa gttacataaa aagtgtgaaa gaacactgtg aggtcccagc   5460

aacgccagac tatattaagg taagtagaaa gtgtttttat agggcttcaa tacccaggtg   5520

gtgacagagc agaagaaccg gttttttttt tttttttttt actactaagc ttttacaaaa   5580

gaagtatctg ttttattgta tagaacaagt acagcatttt actacatagt atacaagttt   5640

ttaatgagca tttaaaaaaa taagtaaatc taggctattt gaaaaataca gttgagccag   5700

tgagcacatt ttataatttg gaagacacaa atcaaatgtg aaggatttga ttttctacat   5760

ttaaaatgaa gaaccaaaac tctcttcttg attttcagct aaaggcagga gactactttc   5820

caactccttt tgcttctgga gaaggccctg aaatcacatt gatatatgtt tgttagtaaa   5880

atgtgcacac ctgacttgca atgttgtgtt aaactagaat tatattcact tggaaaacat   5940

atcgcttagg ataaaatttt gtcattcaaa aattttttca gaaatgcttg tactagacca   6000

cctcatttgg atatatagct atcacatttg taagattctg tttttagcat aaaaatcaat   6060

agggatgaaa attttcttag aactcaagac tccataacta tgggggtaaa tgaagtcatc   6120

ccttctcccc cagtccaccc ccaagtgctc ttagatactg aaggagtctc ccttaacata   6180

cagtgttttt tttttgttgt tgttgttttg tttttttttg gagatggagt ctcgctctgt   6240

cgcccaagct ggagtacagt ggtgcaatct cactgcaagc tctgcctccc aggttcacac   6300

cattctcctg cctcaacctc ccgaatggct gggactacag gcacccacca ccacgcctgg   6360

ctaactaact aactaacttt ttgtattttt agtagagaca gggtttcact gtgttagcca   6420

ggatggtctt gatctcctga cctcatgatc tgcctgcctc agcctcccaa agtgctggga   6480

ttacaggctt gagccactgc tcctggccaa catccagtat tttatcttga ctgtcctaac   6540

cttaccttag atgctaacag aagggtcctg ctgaaataac actgggtgct atattgatgg   6600

gtaaatgtgt acatcctatt ccttcctctt tatctcacaa tttttgtctc cactaagcaa   6660

gaagtaaact aacacttcgt cactctaaag aaataactta tgtaaaactc ttagtaaccc   6720

tgtttgtctt caaatgagta aatagaccaa agtgggggga caattttcta gttctgtaga   6780

gggaaaaaca tctgagtcaa cattttgaaa tgcagagggt attggtacat gacgacatgg   6840

aaaagggcac ttttaaacac agcttactct tcctcaagta cagagagtat atagtgaatc   6900

aaaactaact acagccattc tttttaaagc ccaagggatg gagcaaaggt gtaaggatgt   6960

tacctgtttg ttttaatcag agagcaaaaa gaagtcacaa tagtttggga gaaaaagtag   7020

tatggtgagt aaggttatgc gtataatttc atactgaatt tattactatt tgggatgtac   7080

gtcaatgttc taacaaacac tgccaacacg tcaatttttt aaaaagcgtg ggccacattg   7140

ctaagaattt gttaaagcat aactgtattt tttgttttag ggccttattg atgttttgcc   7200

gttccaatgt atgcattttt ttactcaata aacttgtctt aatttta                 7247


<210>  127
<211>  1233
<212>  PRT
<213>  Homo sapiens

<400>  127


Met Ser Ile Asp His Leu Lys Gln Lys Ile Pro Pro Ala Leu Phe Tyr 
1               5                   10                  15      


Lys Glu Thr Tyr Leu Gly Pro Asn Glu Val Leu Lys Asn Gly Met Tyr 
            20                  25                  30          


Cys Ser Leu Tyr Glu Val Val Glu Lys Thr Arg Ile Gly Ser Asn Met 
        35                  40                  45              


Glu Ser Leu Leu Gln Lys Leu Asp Arg Glu Lys Leu Val Leu Val Lys 
    50                  55                  60                  


Pro Leu Gly Asp Arg Gly Tyr Leu Phe Leu Leu Ser Pro Tyr Gln Met 
65                  70                  75                  80  


Val Pro Pro Tyr Glu Tyr Gln Thr Ala Lys Ser Arg Val Leu His Ala 
                85                  90                  95      


Leu Phe Leu Phe Gln Glu Pro Arg Ser Ile Val Thr Ser Gln Lys Gly 
            100                 105                 110         


Ser Thr Asn Ala Ala Pro Gln Glu Arg His Glu Ser Met Pro Asp Val 
        115                 120                 125             


Leu Lys Ile Ala Gln Phe Leu Gln Phe Ser Leu Ile Gln Cys Arg Lys 
    130                 135                 140                 


Glu Phe Lys Asn Ile Ser Ala Ile Asn Phe His Ser Val Val Glu Lys 
145                 150                 155                 160 


Tyr Val Ser Glu Phe Phe Lys Arg Gly Phe Gly Ser Gly Lys Arg Glu 
                165                 170                 175     


Phe Ile Met Phe Pro Tyr Asp Ser Arg Leu Asp Asp Lys Lys Phe Leu 
            180                 185                 190         


Tyr Ser Ala Pro Arg Asn Lys Ser His Ile Asp Thr Cys Leu His Ala 
        195                 200                 205             


Tyr Ile Phe Arg Pro Glu Val Tyr Gln Leu Pro Ile Cys Lys Leu Lys 
    210                 215                 220                 


Glu Leu Phe Glu Glu Asn Arg Lys Leu Gln Gln Phe Ser Pro Leu Ser 
225                 230                 235                 240 


Asp Tyr Glu Gly Gln Glu Glu Glu Met Asn Gly Thr Lys Met Lys Phe 
                245                 250                 255     


Gly Lys Arg Asn Asn Ser Arg Gly Glu Ala Ile Ile Ser Gly Lys Gln 
            260                 265                 270         


Arg Ser Ser His Ser Leu Asp Tyr Asp Lys Asp Arg Val Lys Glu Leu 
        275                 280                 285             


Ile Asn Leu Ile Gln Cys Arg Lys Lys Ser Val Gly Gly Asp Ser Asp 
    290                 295                 300                 


Thr Glu Asp Met Arg Ser Lys Thr Val Leu Lys Arg Lys Leu Glu Asp 
305                 310                 315                 320 


Leu Pro Glu Asn Met Arg Lys Leu Ala Lys Thr Ser Asn Leu Ser Glu 
                325                 330                 335     


Asn Cys His Leu Tyr Glu Glu Ser Pro Gln Pro Ile Gly Ser Leu Gly 
            340                 345                 350         


His Asp Ala Asp Leu Arg Arg Gln Gln Gln Asp Thr Cys Asn Ser Gly 
        355                 360                 365             


Ile Ala Asp Ile His Arg Leu Phe Asn Trp Leu Ser Glu Thr Leu Ala 
    370                 375                 380                 


Asn Ala Arg His Ser Asp Ala Ser Leu Thr Asp Thr Val Asn Lys Ala 
385                 390                 395                 400 


Leu Gly Leu Ser Thr Asp Asp Ala Tyr Glu Glu Leu Arg Gln Lys His 
                405                 410                 415     


Glu Tyr Glu Leu Asn Ser Thr Pro Asp Lys Lys Asp Tyr Glu Gln Pro 
            420                 425                 430         


Thr Cys Ala Lys Val Glu Asn Ala Gln Phe Lys Gly Thr Gln Ser Leu 
        435                 440                 445             


Leu Leu Glu Val Asp Ala Thr Ser Lys Tyr Ser Val Ala Ile Ser Thr 
    450                 455                 460                 


Ser Glu Val Gly Thr Asp His Lys Leu His Leu Lys Glu Asp Pro Asn 
465                 470                 475                 480 


Leu Ile Ser Val Asn Asn Phe Glu Asp Cys Ser Leu Cys Pro Ser Val 
                485                 490                 495     


Pro Ile Glu His Gly Phe Arg Arg Gln Gln Ser Lys Ser Asn Asn Val 
            500                 505                 510         


Glu Glu Thr Glu Ile His Trp Lys Leu Ile Pro Ile Thr Gly Gly Asn 
        515                 520                 525             


Ala Arg Ser Pro Glu Asp Gln Leu Gly Lys His Gly Glu Lys Gln Thr 
    530                 535                 540                 


Pro Asp Thr Leu Lys Gly Thr Thr Glu Asp Asp Val Leu Thr Gly Gln 
545                 550                 555                 560 


Val Glu Glu Gln Cys Val Pro Ala Ala Glu Ala Glu Pro Pro Ala Val 
                565                 570                 575     


Ser Glu Thr Thr Glu Arg Thr Val Leu Gly Glu Tyr Asn Leu Phe Ser 
            580                 585                 590         


Arg Lys Ile Glu Glu Ile Leu Lys Gln Lys Asn Val Ser Tyr Val Ser 
        595                 600                 605             


Thr Val Ser Thr Pro Ile Phe Ser Thr Gln Glu Lys Met Lys Arg Leu 
    610                 615                 620                 


Ser Glu Phe Ile Tyr Ser Lys Thr Ser Lys Ala Gly Val Gln Glu Phe 
625                 630                 635                 640 


Val Asp Gly Leu His Glu Lys Leu Asn Thr Ile Ile Ile Lys Ala Ser 
                645                 650                 655     


Ala Lys Gly Gly Asn Leu Pro Pro Val Ser Pro Asn Asp Ser Gly Ala 
            660                 665                 670         


Lys Ile Ala Ser Asn Pro Leu Glu Arg His Val Ile Pro Val Ser Ser 
        675                 680                 685             


Ser Asp Phe Asn Asn Lys His Leu Leu Glu Pro Leu Cys Ser Asp Pro 
    690                 695                 700                 


Leu Lys Asp Thr Asn Ser Asp Glu Gln His Ser Thr Ser Ala Leu Thr 
705                 710                 715                 720 


Glu Val Glu Met Asn Gln Pro Gln His Ala Thr Glu Leu Met Val Thr 
                725                 730                 735     


Ser Asp His Ile Val Pro Gly Asp Met Ala Arg Glu Pro Val Glu Glu 
            740                 745                 750         


Thr Thr Lys Ser Pro Ser Asp Val Asn Ile Ser Ala Gln Pro Ala Leu 
        755                 760                 765             


Ser Asn Phe Ile Ser Gln Leu Glu Pro Glu Val Phe Asn Ser Leu Val 
    770                 775                 780                 


Lys Ile Met Lys Asp Val Gln Lys Asn Thr Val Lys Phe Tyr Ile His 
785                 790                 795                 800 


Glu Glu Glu Glu Ser Val Leu Cys Lys Glu Ile Lys Glu Tyr Leu Ile 
                805                 810                 815     


Lys Leu Gly Asn Thr Glu Cys His Pro Glu Gln Phe Leu Glu Arg Arg 
            820                 825                 830         


Ser Lys Leu Asp Lys Leu Leu Ile Ile Ile Gln Asn Glu Asp Ile Ala 
        835                 840                 845             


Gly Phe Ile His Lys Ile Pro Gly Leu Val Thr Leu Lys Lys Leu Pro 
    850                 855                 860                 


Cys Val Ser Phe Ala Gly Val Asp Ser Leu Asp Asp Val Lys Asn His 
865                 870                 875                 880 


Thr Tyr Asn Glu Leu Phe Val Ser Gly Gly Phe Ile Val Ser Asp Glu 
                885                 890                 895     


Ser Ile Leu Asn Pro Glu Val Val Thr Val Glu Asn Leu Lys Asn Phe 
            900                 905                 910         


Leu Thr Phe Leu Glu Glu Leu Ser Thr Pro Glu Gly Lys Trp Gln Trp 
        915                 920                 925             


Lys Val His Cys Lys Phe Gln Lys Lys Leu Lys Glu Leu Gly Arg Leu 
    930                 935                 940                 


Asn Ala Lys Ala Leu Ser Leu Leu Thr Leu Leu Asn Val Tyr Gln Lys 
945                 950                 955                 960 


Lys His Leu Val Glu Ile Leu Ser Tyr His Asn Cys Asp Ser Gln Thr 
                965                 970                 975     


Arg Asn Ala Pro Glu Leu Asp Cys Leu Ile Arg Leu Gln Ala Gln Asn 
            980                 985                 990         


Ile Gln Gln Arg His Ile Val Phe  Leu Thr Glu Lys Asn  Ile Lys Met 
        995                 1000                 1005             


Leu Ser  Ser Tyr Thr Asp Asn  Gly Ile Val Val Ala  Thr Ala Glu 
    1010                 1015                 1020             


Asp Phe  Met Gln Asn Phe Lys  Asn Leu Val Gly Tyr  His Asn Ser 
    1025                 1030                 1035             


Ile Thr  Glu Glu Asn Leu Pro  Gln Leu Gly Ala Asn  Glu Asn Leu 
    1040                 1045                 1050             


Glu Ser  Gln Ser Ala Leu Leu  Glu Asn Asp Glu Lys  Asp Glu Glu 
    1055                 1060                 1065             


Asp Met  Ser Leu Asp Ser Gly  Asp Glu Ile Ser His  Ile Glu Val 
    1070                 1075                 1080             


Cys Ser  Asn Phe His Ser Glu  Ile Trp Glu Lys Glu  Thr Lys Gly 
    1085                 1090                 1095             


Ser Arg  Gly Thr Asp Gln Lys  Lys Asn Thr Gln Ile  Glu Leu Gln 
    1100                 1105                 1110             


Ser Ser  Pro Asp Val Gln Asn  Ser Leu Leu Glu Asp  Lys Thr Tyr 
    1115                 1120                 1125             


Leu Asp  Ser Glu Glu Arg Thr  Ser Ile Asp Ile Val  Cys Ser Glu 
    1130                 1135                 1140             


Gly Glu  Asn Ser Asn Ser Thr  Glu Gln Asp Ser Tyr  Ser Asn Phe 
    1145                 1150                 1155             


Gln Val  Tyr His Ser Gln Leu  Asn Met Ser His Gln  Phe Ser His 
    1160                 1165                 1170             


Phe Asn  Val Leu Thr His Gln  Thr Phe Leu Gly Thr  Pro Tyr Ala 
    1175                 1180                 1185             


Leu Ser  Ser Ser Gln Ser Gln  Glu Asn Glu Asn Tyr  Phe Leu Ser 
    1190                 1195                 1200             


Ala Tyr  Thr Glu Ser Leu Asp  Arg Asp Lys Ser Pro  Pro Pro Leu 
    1205                 1210                 1215             


Ser Trp  Gly Lys Ser Asp Ser  Ser Arg Pro Tyr Ser  Gln Glu Lys 
    1220                 1225                 1230             

<210>  128
<211>  3612
<212>  DNA
<213>  Homo sapiens

<400>  128
cactcggctc cggagcccag tcgagtcctg cccggctaga agccggctgt cggtctccgt     60

gtcgccgccg ccgcccggca tcgtggagct ggggccccct tttgcctggg agttttgtag    120

tcgcctaggg tcagcggtga catcccaaag ggcaggcccg gcagccgcca tggtggccaa    180

ggattacccc ttctacctca cggtcaagag agcgaactgc agcctggagc tacccccggc    240

cagcggtccg gccaaggacg ctgaggagcc tagtaataaa cgggtcaaac ccctttcccg    300

agtcacgtcg ctagcaaacc tcatcccgcc cgtgaaggcc acgccattaa agcgcttcag    360

tcaaaccctg cagcgctcca ttagcttccg cagtgagagc cgccctgaca tcctcgcccc    420

ccgaccctgg tccagaaatg ccgccccctc gagcacgaaa cggagagata gcaagctgtg    480

gagtgagacc ttcgatgtgt gcgtcaatca gatgcttaca tccaaggaaa tcaaacgtca    540

ggaggcgatc tttgagcttt cccaaggaga agaagacttg atagaagact tgaaattagc    600

aaaaaaggcc tatcatgacc ccatgctgaa actctccata atgacagaac aagagttgaa    660

tcaaattttt ggaacactgg actctctaat tcctctacat gaagagctcc ttagtcagct    720

tcgagatgtt aggaagcctg atggctcgac tgaacatgtt ggtcccatcc tcgtgggctg    780

gctcccttgc ctcagctcct atgatagcta ctgcagcaat caagtagccg ccaaagctct    840

gctggaccac aaaaagcaag atcaccgagt ccaggatttc ctacagcgat gtttagaatc    900

cccctttagc cgcaaactag atctctggaa tttcctcgat attccaagaa gccgcctggt    960

aaaataccct ctgcttctcc gagaaatctt gaggcacaca ccaaatgata atccagatca   1020

gcagcacttg gaagaagcta taaatatcat tcagggaatt gtggcagaaa tcaacaccaa   1080

gactggtgaa tctgaatgcc gctattataa agagcggctt ctttacttgg aagaaggcca   1140

gaaagactcc ctgatcgaca gctctcgagt cttgtgttgt catggtgaac tgaagaacaa   1200

tcggggcgtg aaactgcatg ttttcctgtt ccaagaagtg cttgtgatca ctcgagccgt   1260

cacccacaat gagcagcttt gctaccagct gtaccgtcag ccaatccccg tgaaagacct   1320

cctgctggaa gacctccagg atggagaagt gaggctgggt ggctccctgc gaggggcatt   1380

cagcaacaat gagagaatta aaaacttctt cagagtcagt ttcaaaaatg gatcccaaag   1440

tcagacccac tcgctacaag ccaatgacac tttcaacaaa cagcagtggc ttaactgtat   1500

tcgtcaagcc aaagaaacag ttttgtgtgc tgccgggcaa gctggggtgc ttgactccga   1560

gggatcgttc ctaaatccca ccaccgggag cagagagcta cagggagaaa caaaacttga   1620

gcagatggac caatcggaca gtgagtcaga ctgtagtatg gacacgagtg aggtcagcct   1680

cgactgtgag cgcatggaac agacagactc ttcctgtgga aacagcaggc acggtgaaag   1740

taacgtctga cagaagcatg tgcacttcgg gaagcaggcc tgcatcttac ctgtacagta   1800

tttgcattcc acagatggaa cggtttggag aagcactttt tcatactttt gtgaaagtat   1860

acatgttggc ccagtctctc gtatctgtac ctttgtccct agtactgtaa ctgccaatct   1920

gtctgtgtaa gctggaatct gtggcaacta ttaccctgtg ttgtatttcc caagtgtctg   1980

gatggatgga gaggtactca aacaagttac tttcagttgt cctgctggat tttaaaaaaa   2040

tagaaaaaga atctcaaaac tactgtttta catagattgt ttgaagagtc cttcctcttg   2100

tgcttctgta ccactttccc agctcttaga tgtggtagct aaaggcacgg aatttagacg   2160

gccttgtaaa tagggcatga ggaactcatc tgtgtattgg gatggtatta gagagagaat   2220

caggaaagac caactcatga agtgaacttg gtttgatctt actcaactag aaagcttgaa   2280

aacatccctg gggattctga aggcttaatt ttgcaaagga ggatgcattg tctgaacttt   2340

gcaacttcat ccagtgcaag tttgatgcaa gaatgtatta ggacataaaa tagaggctga   2400

ccttaaaagg gccaggacag aagcggctgc cagctctgaa tctttaactg aaatgcacat   2460

ggcaccagga ggtgtctctc atagttggtt gctagcctaa aacatcagaa tagaacccaa   2520

agggcttagg aaggcctgcc aggataacaa gaaggccctg tattcattgt gtttcatctg   2580

cctaggccta ctcattattt tagagaatga atgaagcaac aaggaagaga gaccatgact   2640

ctatcgatga cactgtttat agaaacacag gagaggaaga atttggaatg aaaagcactt   2700

cgtcagaacc ttctgtggga gccattgaga gaaaagcatg gtccagtgcc ttctgagaaa   2760

ggccagagct ttgggctttc ctgctctgct tttgggtcgt caatttgcca tctctggttc   2820

tgtgctataa tcagaattgt aattatgttc tccagaggcc aatttcatta actctgatta   2880

attagaatca gctagccaga ttagtaacct ctttgtccag ccttgattta cagtgcaggg   2940

taaagtgcag accttaaaaa cagctaagta cctagaagag ctccctgcaa gtgtaaatat   3000

taaggatgac ctgtgcaaaa ttatacccac accagcacta gtggtaatta ttctaaatta   3060

ttgccaaaaa gtttttttta atctgtcttt caagtttaca gaaaagaaag cagtaaatgc   3120

attgatgtca ttttattatg tacatatatc atgtgcattc aagctgtgtg acaagatata   3180

tcaatataaa aacaaggtat atactttatt attttttgaa aacaaggata ttgtgatcaa   3240

ttttaccctg taaaacatat ttctgtattt ataggtctta aacatgatga attttttcta   3300

ttacaagttt atttaaaact gctttctcaa gtcgttattg atacagcaag tgaacctgct   3360

gcagacagaa gcagaggaaa gccaagaaca gcctttattg gtgaagaaaa gaatgaatga   3420

ttctttgtag gcgccatcag ccacttttag aagccatcag ccagtgtgtt gggaaaagag   3480

gtttgtcaag tgttggccta tgggaaggtg gtcaatgaat gttttgatga aatgaatgtt   3540

tttgtataat ggccttaaac ttttctggaa gtatttcaaa taaattacat tattaagtca   3600

tcaaaaaaaa aa                                                       3612


<210>  129
<211>  526
<212>  PRT
<213>  Homo sapiens

<400>  129


Met Val Ala Lys Asp Tyr Pro Phe Tyr Leu Thr Val Lys Arg Ala Asn 
1               5                   10                  15      


Cys Ser Leu Glu Leu Pro Pro Ala Ser Gly Pro Ala Lys Asp Ala Glu 
            20                  25                  30          


Glu Pro Ser Asn Lys Arg Val Lys Pro Leu Ser Arg Val Thr Ser Leu 
        35                  40                  45              


Ala Asn Leu Ile Pro Pro Val Lys Ala Thr Pro Leu Lys Arg Phe Ser 
    50                  55                  60                  


Gln Thr Leu Gln Arg Ser Ile Ser Phe Arg Ser Glu Ser Arg Pro Asp 
65                  70                  75                  80  


Ile Leu Ala Pro Arg Pro Trp Ser Arg Asn Ala Ala Pro Ser Ser Thr 
                85                  90                  95      


Lys Arg Arg Asp Ser Lys Leu Trp Ser Glu Thr Phe Asp Val Cys Val 
            100                 105                 110         


Asn Gln Met Leu Thr Ser Lys Glu Ile Lys Arg Gln Glu Ala Ile Phe 
        115                 120                 125             


Glu Leu Ser Gln Gly Glu Glu Asp Leu Ile Glu Asp Leu Lys Leu Ala 
    130                 135                 140                 


Lys Lys Ala Tyr His Asp Pro Met Leu Lys Leu Ser Ile Met Thr Glu 
145                 150                 155                 160 


Gln Glu Leu Asn Gln Ile Phe Gly Thr Leu Asp Ser Leu Ile Pro Leu 
                165                 170                 175     


His Glu Glu Leu Leu Ser Gln Leu Arg Asp Val Arg Lys Pro Asp Gly 
            180                 185                 190         


Ser Thr Glu His Val Gly Pro Ile Leu Val Gly Trp Leu Pro Cys Leu 
        195                 200                 205             


Ser Ser Tyr Asp Ser Tyr Cys Ser Asn Gln Val Ala Ala Lys Ala Leu 
    210                 215                 220                 


Leu Asp His Lys Lys Gln Asp His Arg Val Gln Asp Phe Leu Gln Arg 
225                 230                 235                 240 


Cys Leu Glu Ser Pro Phe Ser Arg Lys Leu Asp Leu Trp Asn Phe Leu 
                245                 250                 255     


Asp Ile Pro Arg Ser Arg Leu Val Lys Tyr Pro Leu Leu Leu Arg Glu 
            260                 265                 270         


Ile Leu Arg His Thr Pro Asn Asp Asn Pro Asp Gln Gln His Leu Glu 
        275                 280                 285             


Glu Ala Ile Asn Ile Ile Gln Gly Ile Val Ala Glu Ile Asn Thr Lys 
    290                 295                 300                 


Thr Gly Glu Ser Glu Cys Arg Tyr Tyr Lys Glu Arg Leu Leu Tyr Leu 
305                 310                 315                 320 


Glu Glu Gly Gln Lys Asp Ser Leu Ile Asp Ser Ser Arg Val Leu Cys 
                325                 330                 335     


Cys His Gly Glu Leu Lys Asn Asn Arg Gly Val Lys Leu His Val Phe 
            340                 345                 350         


Leu Phe Gln Glu Val Leu Val Ile Thr Arg Ala Val Thr His Asn Glu 
        355                 360                 365             


Gln Leu Cys Tyr Gln Leu Tyr Arg Gln Pro Ile Pro Val Lys Asp Leu 
    370                 375                 380                 


Leu Leu Glu Asp Leu Gln Asp Gly Glu Val Arg Leu Gly Gly Ser Leu 
385                 390                 395                 400 


Arg Gly Ala Phe Ser Asn Asn Glu Arg Ile Lys Asn Phe Phe Arg Val 
                405                 410                 415     


Ser Phe Lys Asn Gly Ser Gln Ser Gln Thr His Ser Leu Gln Ala Asn 
            420                 425                 430         


Asp Thr Phe Asn Lys Gln Gln Trp Leu Asn Cys Ile Arg Gln Ala Lys 
        435                 440                 445             


Glu Thr Val Leu Cys Ala Ala Gly Gln Ala Gly Val Leu Asp Ser Glu 
    450                 455                 460                 


Gly Ser Phe Leu Asn Pro Thr Thr Gly Ser Arg Glu Leu Gln Gly Glu 
465                 470                 475                 480 


Thr Lys Leu Glu Gln Met Asp Gln Ser Asp Ser Glu Ser Asp Cys Ser 
                485                 490                 495     


Met Asp Thr Ser Glu Val Ser Leu Asp Cys Glu Arg Met Glu Gln Thr 
            500                 505                 510         


Asp Ser Ser Cys Gly Asn Ser Arg His Gly Glu Ser Asn Val 
        515                 520                 525     

<210>  130
<211>  9463
<212>  DNA
<213>  Homo sapiens

<400>  130
gcggccaggg gcgggcggcc gcagagcagc accggccgtg gctccggtag cagcaagttc     60

gaaccccgct cccgctccgc ttcggttctc gctccttcgg cccttgggcc tccaaacacc    120

agtccccggc agctcgttgc gcattgcgct ctccccgcca ccaggatgcc ggtaaccgag    180

aaggatctag ctgaggacgc gccttggaag aagatccagc agaacacgtt cacacgctgg    240

tgcaacgagc acctcaagtg cgtgaacaaa cgcatcggca acctgcagac cgacctgagc    300

gacgggctgc ggctcatcgc gctgctcgag gtgctcagcc agaagcgcat gtaccgcaag    360

taccatcagc ggcccacctt tcgccagatg cagctcgaga atgtgtccgt ggcgctcgag    420

ttcctggacc gtgagagcat caagctcgtg tccatcgata gcaaagccat tgtggatggg    480

aacctgaagc tcatcttggg tctggtgtgg acgctgatcc tccactactc catctccatg    540

cccgtgtggg aggatgaagg ggatgatgat gccaagaagc agacgccaaa gcagaggctg    600

ctggggtgga ttcagaacaa gatcccctac ttgcccatca ccaactttaa ccagaactgg    660

caagacggca aagccctggg agccctggta gacagctgtg ctccaggtct gtgcccagac    720

tgggaatcct gggacccgca gaagcctgtg gataatgcac gagaagccat gcagcaggca    780

gatgactggc tgggtgtccc acaggtcatc actcctgaag aaatcattca cccggatgtg    840

gacgagcact cagttatgac ttacctgtcc cagttcccca aagccaagct caagccgggg    900

gctcctctca aacccaaact caacccgaag aaagccaggg cctatggcag aggaatcgag    960

cccactggaa acatggtgaa gcagccagcc aagttcactg tggacaccat cagcgccggg   1020

caaggagacg tgatggtgtt tgttgaggac ccagaaggga acaaagagga ggcacaagtg   1080

acccctgaca gtgacaagaa caagacatac tctgtggagt atctgcccaa ggtcaccggg   1140

ctacacaaag tcacagtcct ctttgcagga cagcacatct ccaagagccc atttgaagtg   1200

agtgttgaca aggcccaggg agatgccagt aaagtcactg caaaaggtcc agggttggaa   1260

gctgtaggga acatcgccaa taagcccacc tactttgaca tctatacggc aggagctggt   1320

gtgggtgaca ttggtgtgga ggtggaagat ccccagggga agaacaccgt ggagttgctc   1380

gtggaagaca aaggaaacca ggtgtatcga tgtgtgtaca aacccatgca gcctggccct   1440

cacgtggtca agatcttctt tgctggggac actattccta agagtccctt cgttgtgcag   1500

gttggggaag cctgcaatcc aaatgcctgc cgggccagtg gccgaggcct acaacccaaa   1560

ggcgtccgta tccgggagac cacagatttc aaggttgaca ccaaagctgc aggaagtggg   1620

gagctcggtg taaccatgaa gggtcctaag ggtctggagg agctggtgaa gcagaaagac   1680

tttctggatg gggtctacgc attcgagtat taccccagca ccccggggag atacagcatt   1740

gccatcacat gggggggaca ccacattcca aagagcccct ttgaagttca agttggccct   1800

gaagcgggta tgcagaaagt ccgtgcttgg ggccctgggc tccatggtgg gattgtcggg   1860

cggtcagcgg acttcgtggt agaatccatt ggctctgaag tggggtctct ggggtttgcc   1920

attgaaggcc cctctcaggc aaagattgag tacaacgacc agaatgatgg atcgtgtgat   1980

gtcaaatact ggcccaagga gcctggcgaa tatgctgttc acatcatgtg tgacgacgaa   2040

gacatcaagg acagcccgta catggccttc atccacccag ccacgggagg ctacaaccct   2100

gatctggttc gagcatacgg gccaggtttg gagaaatctg gatgcattgt caacaacctg   2160

gccgagttca ctgtggatcc taaggatgct ggaaaagctc ccttaaagat atttgctcag   2220

gatggggaag gccaacgcat tgacatccag atgaagaacc ggatggacgg cacatatgca   2280

tgctcataca ccccggtgaa ggccatcaag cacaccattg ctgtggtctg gggaggcgtg   2340

aacatcccgc acagccccta cagggtcaac atcgggcaag gtagccatcc tcagaaggtc   2400

aaagtgtttg ggccaggtgt ggagagaagt ggtctgaagg caaatgaacc tacacacttc   2460

acggtggact gtactgaggc tggggaaggt gatgtcagtg ttggcattaa gtgtgatgcc   2520

cgggtgttaa gtgaagatga ggaagacgtg gattttgaca ttattcacaa tgccaatgat   2580

acgttcacag tcaaatatgt gcctcctgct gctgggcgat acactatcaa agttctcttt   2640

gcatctcagg aaatccccgc cagccctttc agagtcaaag ttgacccttc ccacgatgcc   2700

agcaaagtga aggcagaagg cccagggctc agcaaagcag gtgtggaaaa tgggaaaccg   2760

acccacttca ctgtctacac caagggggct gggaaagccc cgctcaacgt gcagttcaac   2820

agccctcttc ctggcgatgc agtgaaggat ttggatatca tcgataatta tgactactct   2880

cacacggtta aatatacacc cacccaacag ggcaacatgc aggttctggt gacttacggt   2940

ggcgatccca tccctaaaag ccctttcact gtgggtgttg ctgcaccgct ggatctgagc   3000

aagataaaac tcaatgggct ggaaaacagg gtggaagttg ggaaggatca ggagttcacc   3060

gttgatacca ggggggcagg aggccagggg aagctggacg tgacaatcct cagcccctct   3120

cggaaggtcg tgccatgcct agtgacacct gtgacaggcc gggagaacag cacggccaag   3180

ttcatccctc gggaggaggg gctgtatgct gtagacgtga cctacgatgg acaccctgtg   3240

cccgggagcc cctacacagt ggaggcctcg ctgccaccag atcccagcaa ggtgaaggcc   3300

cacggtcccg gcctcgaagg tggtctcgtg ggcaagcctg ccgagttcac catcgatacc   3360

aaaggagctg gtactggagg tctgggctta acggtggaag gtccgtgcga ggccaaaatc   3420

gagtgctccg acaatggtga tgggacctgc tccgtctctt accttcccac aaaacccggg   3480

gagtacttcg tcaacatcct ctttgaagaa gtccacatac ctgggtctcc cttcaaagct   3540

gacattgaaa tgccctttga cccctctaaa gtcgtggcat cggggccagg tctcgagcac   3600

gggaaggtgg gtgaagctgg cctccttagc gtcgactgct cggaagcggg accgggggcc   3660

ctgggcctgg aagctgtctc ggactcggga acaaaagccg aagtcagtat tcagaacaac   3720

aaagatggca cctacgcggt gacctacgtg cccctgacgg ccggcatgta cacgttgacc   3780

atgaagtatg gtggcgaact cgtgccacac ttccccgccc gggtcaaggt ggagcccgcc   3840

gtggacacca gcaggatcaa agtctttgga ccaggaatag aagggaaaga tgtgttccgg   3900

gaagctacca ccgactttac agttgactct cggccgctga cccaggttgg gggtgaccac   3960

atcaaggccc acattgccaa cccctcaggg gcctccaccg agtgctttgt cacagacaat   4020

gcggatggga cctaccaggt ggaatacaca ccctttgaga aaggtctcca tgtagtggag   4080

gtgacatatg atgacgtgcc tatcccaaac agtcccttca aggtggctgt cactgaaggc   4140

tgccagccat ctagggtgca agcccaagga cctggattga aagaggcctt taccaacaag   4200

cccaatgtct tcaccgtggt taccagaggc gcaggaattg gtgggcttgg cataactgtt   4260

gagggaccat cagagtcgaa gataaattgc agagacaaca aggatggcag ctgcagtgct   4320

gagtacattc ctttcgcacc gggggattac gatgttaata tcacatatgg aggagcccac   4380

atccccggca gccccttcag ggttcctgtg aaggatgttg tggaccccag caaggtcaag   4440

attgccggcc ccgggctggg ctcaggcgtc cgagcccgtg tcctgcagtc cttcacggtg   4500

gacagcagca aggctggcct ggctccgctg gaagtgaggg ttctgggccc acgaggcttg   4560

gtggagccag tgaacgtggt ggacaatgga gatggcacac acacagtaac ctacacccca   4620

tctcaggagg gaccttacat ggtctcagtt aaatatgctg atgaagagat tcctcgcagt   4680

cccttcaagg tcaaggtcct tcccacatat gatgccagca aagtgactgc cagtggcccc   4740

ggccttagtt cctatggtgt gcctgccagt ctacctgtgg actttgcaat tgatgcccga   4800

gatgccgggg aaggcctgct tgctgttcaa ataacggacc aagaaggaaa acccaaaaga   4860

gccattgtcc atgacaataa agatggcacg tatgctgtca cctacatccc cgacaagact   4920

gggcgctata tgattggagt cacctacggg ggtgacgaca tcccactttc tccttatcgc   4980

atccgagcca cacagacggg tgatgccagc aagtgcctgg ccacgggtcc tggaatcgcc   5040

tccactgtga aaactggcga agaagtaggc tttgtggttg atgccaagac tgccgggaag   5100

ggtaaagtga cctgcacggt tctgacccca gatggcactg aggccgaggc cgatgtcatt   5160

gagaatgaag atggaaccta tgacatcttc tacacagctg ccaagccggg cacatatgtg   5220

atctatgtgc gcttcggtgg tgttgatatt cctaacagcc ccttcactgt catggccaca   5280

gatggggaag tcacagccgt ggaggaggca ccggtaaatg catgtccccc tggattcagg   5340

ccctgggtga ccgaagaggc ctatgtccca gtgagtgaca tgaacggcct gggatttaag   5400

ccttttgacc tggtcattcc gtttgctgtc aggaaaggag aaatcactgg agaggtccac   5460

atgccttctg ggaagacagc cacacctgag attgtggaca acaaggacgg cacggtcact   5520

gttagatatg cccccactga ggtcgggctc catgagatgc acatcaaata catgggcagc   5580

cacatccctg agagcccact ccagttctac gtgaactacc ccaacagtgg aagtgtttct   5640

gcatacggtc caggcctcgt gtatggagtg gccaacaaaa ctgccacctt caccatcgtc   5700

acagaggatg caggagaagg tggtctggac ttggctattg agggcccctc aaaagcagaa   5760

atcagctgca ttgacaataa agatgggaca tgcacagtga cctacctgcc gactctgcca   5820

ggcgactaca gcattctggt caagtacaat gacaagcaca tccctggcag ccccttcaca   5880

gccaagatca cagatgacag caggcggtgc tcccaggtga agttgggctc agccgctgac   5940

ttcctgctcg acatcagtga gactgacctc agcagcctga cggccagcat taaggcccca   6000

tctggccgag acgagccctg tctcctgaag aggctgccca acaaccacat tggcatctcc   6060

ttcatccccc gggaagtggg cgaacatctg gtcagcatca agaaaaatgg caaccatgtg   6120

gccaacagcc ccgtgtctat catggtggtc cagtcggaga ttggtgacgc ccgccgagcc   6180

aaagtctatg gccgcggcct gtcagaaggc cggactttcg agatgtctga cttcatcgtg   6240

gacacaaggg atgcaggtta tggtggcata tccttggcgg tggaaggccc cagcaaagtg   6300

gacatccaga cggaggacct ggaagatggc acctgcaaag tctcctactt ccctaccgtg   6360

cctggggttt atatcgtctc caccaaattc gctgacgagc acgtgcctgg gagcccattt   6420

accgtgaaga tcagtgggga gggaagagtc aaagagagca tcacccgcac cagtcgggcc   6480

ccgtccgtgg ccactgtcgg gagcatttgt gacctgaacc tgaaaatccc agaaatcaac   6540

agcagtgata tgtcggccca cgtcaccagc ccctctggcc gtgtgactga ggcagagatt   6600

gtgcccatgg ggaagaactc acactgcgtc cggtttgtgc cccaggagat gggcgtgcac   6660

acggtcagcg tcaagtaccg tgggcagcac gtcaccggca gccccttcca gttcaccgtg   6720

gggccacttg gtgaaggagg cgcccacaag gtgcgggcag gaggccctgg cctggagaga   6780

ggagaagcgg gagtcccagc tgagttcagc atttggaccc gggaagcagg cgctggaggc   6840

ctctccatcg ctgttgaggg ccccagtaag gccgagatta cattcgatga ccataaaaat   6900

gggtcgtgcg gtgtatctta tattgcccaa gagcctggta actacgaggt gtccatcaag   6960

ttcaatgatg agcacatccc ggaaagcccc tacctggtgc cggtcatcgc accctccgac   7020

gacgcccgcc gcctcactgt tatgagcctt caggaatcgg gattaaaagt taaccagcca   7080

gcatcctttg ctataaggtt gaatggcgca aaaggcaaga ttgatgcaaa ggtgcacagc   7140

ccctctggag ccgtggagga gtgccacgtg tctgagctgg agccagataa gtatgctgtt   7200

cgcttcatcc ctcatgagaa tggtgtccac accatcgatg tcaagttcaa tgggagccac   7260

gtggttggaa gccccttcaa agtgcgcgtt ggggagcctg gacaagcggg gaaccctgcc   7320

ctggtgtccg cctatggcac gggactcgaa gggggcacca caggtatcca gtcggaattc   7380

tttattaaca ccacccgagc aggtccaggg acattatccg tcaccatcga aggcccatcc   7440

aaggttaaaa tggattgcca ggaaacacct gaagggtaca aagtcatgta cacccccatg   7500

gctcctggta actacctgat cagcgtcaaa tacggtgggc ccaaccacat cgtgggcagt   7560

cccttcaagg ccaaggtgac aggccagcgt ctagttagcc ctggctcagc caacgagacc   7620

tcatccatcc tggtggagtc agtgaccagg tcgtctacag agacctgcta tagcgccatt   7680

cccaaggcat cctcggacgc cagcaaggtg acctctaagg gggcagggct ctcaaaggcc   7740

tttgtgggcc agaagagttc cttcctggtg gactgcagca aagctggctc caacatgctg   7800

ctgatcgggg tccatgggcc caccaccccc tgcgaggagg tctccatgaa gcatgtaggc   7860

aaccagcaat acaacgtcac atacgtcgtc aaggagaggg gcgattatgt gctggctgtg   7920

aagtgggggg aggaacacat ccctggcagc ccttttcatg tcacagtgcc ttaaaacagt   7980

tttctcaaat cctggagaga gttcttgtgg ttgcttttgt tgcttgtttg taattcattt   8040

tatacaaagc cctccagcct gtttgtgggg ctgaaacccc atccctaaaa tattgctgtt   8100

gtaaaatgcc ttcagaaata agtcctagac tggactcttg agggacatat tggagaatct   8160

taagaaatgc aagcttgttc agggggctga gaagatcctg agtacactag gtgcaaacca   8220

gaactcttgg tggaacagac cagccactgc agcagacaga ccaggaacac aatgagactg   8280

acatttcaaa aaaacaaaac tggctagcct gagctgctgg ttcactcttc agcatttatg   8340

aaacaaggct aggggaagat gggcagagaa aaaggggaca cctagtttgg ttgtcatttg   8400

gcaaaggaga tgacttaaaa tccgcttaat ctcttccagt gtccgtgtta atgtatttgg   8460

ctattagatc actagcactg ctttaccgct cctcatcgcc aacaccccca tgctctgtgg   8520

ccttcttaca cttctcagag ggcagagtgg cagccgggca ccctacagaa actcagaggg   8580

cagagtggca gccaggccca catgtctctc aagtacctgt cccctcgctc tggtgattat   8640

ttcttgcaga atcaccacac gagaccatcc cggcagtcat ggttttgctt tagttttcca   8700

agtccgtttc agtcccttcc ttggtctgaa gaaattctgc agtggcgagc agtttcccac   8760

ttgccaaaga tcccttttaa ccaacactag cccttgtttt taacacacgc tccagccctt   8820

catcagcctg ggcagtctta ccaaaatgtt taaagtgatc tcagaggggc ccatggatta   8880

acgccctcat cccaaggtcc gtcccatgac ataacactcc acacccgccc cagccaactt   8940

catgggtcac tttttctgga aaataatgat ctgtacagac aggacagaat gaaactcctg   9000

cgggtctttg gcctgaaagt tgggaatggt tgggggagag aagggcagca gcttattggt   9060

ggtcttttca ccattggcag aaacagtgag agctgtgtgg tgcagaaatc cagaaatgag   9120

gtgtagggaa ttttgcctgc cttcctgcag acctgagctg gctttggaat gaggttaaag   9180

tgtcagggac gttgcctgag cccaaatgtg tagtgtggtc tgggcaggca gacctttagg   9240

ttttgctgct tagtcctgag gaagtggcca ctcttgtggc aggtgtagta tctggggcga   9300

gtgttggggg taaaagccca ccctacagaa agtggaacag cccggagcct gatgtgaaag   9360

gaccacgggt gttgtaagct gggacacgga agccaaactg gaatcaaacg ccgactgtaa   9420

attgtatctt ataacttatt aaataaaaca tttgctccgt aaa                     9463


<210>  131
<211>  2602
<212>  PRT
<213>  Homo sapiens

<400>  131


Met Pro Val Thr Glu Lys Asp Leu Ala Glu Asp Ala Pro Trp Lys Lys 
1               5                   10                  15      


Ile Gln Gln Asn Thr Phe Thr Arg Trp Cys Asn Glu His Leu Lys Cys 
            20                  25                  30          


Val Asn Lys Arg Ile Gly Asn Leu Gln Thr Asp Leu Ser Asp Gly Leu 
        35                  40                  45              


Arg Leu Ile Ala Leu Leu Glu Val Leu Ser Gln Lys Arg Met Tyr Arg 
    50                  55                  60                  


Lys Tyr His Gln Arg Pro Thr Phe Arg Gln Met Gln Leu Glu Asn Val 
65                  70                  75                  80  


Ser Val Ala Leu Glu Phe Leu Asp Arg Glu Ser Ile Lys Leu Val Ser 
                85                  90                  95      


Ile Asp Ser Lys Ala Ile Val Asp Gly Asn Leu Lys Leu Ile Leu Gly 
            100                 105                 110         


Leu Val Trp Thr Leu Ile Leu His Tyr Ser Ile Ser Met Pro Val Trp 
        115                 120                 125             


Glu Asp Glu Gly Asp Asp Asp Ala Lys Lys Gln Thr Pro Lys Gln Arg 
    130                 135                 140                 


Leu Leu Gly Trp Ile Gln Asn Lys Ile Pro Tyr Leu Pro Ile Thr Asn 
145                 150                 155                 160 


Phe Asn Gln Asn Trp Gln Asp Gly Lys Ala Leu Gly Ala Leu Val Asp 
                165                 170                 175     


Ser Cys Ala Pro Gly Leu Cys Pro Asp Trp Glu Ser Trp Asp Pro Gln 
            180                 185                 190         


Lys Pro Val Asp Asn Ala Arg Glu Ala Met Gln Gln Ala Asp Asp Trp 
        195                 200                 205             


Leu Gly Val Pro Gln Val Ile Thr Pro Glu Glu Ile Ile His Pro Asp 
    210                 215                 220                 


Val Asp Glu His Ser Val Met Thr Tyr Leu Ser Gln Phe Pro Lys Ala 
225                 230                 235                 240 


Lys Leu Lys Pro Gly Ala Pro Leu Lys Pro Lys Leu Asn Pro Lys Lys 
                245                 250                 255     


Ala Arg Ala Tyr Gly Arg Gly Ile Glu Pro Thr Gly Asn Met Val Lys 
            260                 265                 270         


Gln Pro Ala Lys Phe Thr Val Asp Thr Ile Ser Ala Gly Gln Gly Asp 
        275                 280                 285             


Val Met Val Phe Val Glu Asp Pro Glu Gly Asn Lys Glu Glu Ala Gln 
    290                 295                 300                 


Val Thr Pro Asp Ser Asp Lys Asn Lys Thr Tyr Ser Val Glu Tyr Leu 
305                 310                 315                 320 


Pro Lys Val Thr Gly Leu His Lys Val Thr Val Leu Phe Ala Gly Gln 
                325                 330                 335     


His Ile Ser Lys Ser Pro Phe Glu Val Ser Val Asp Lys Ala Gln Gly 
            340                 345                 350         


Asp Ala Ser Lys Val Thr Ala Lys Gly Pro Gly Leu Glu Ala Val Gly 
        355                 360                 365             


Asn Ile Ala Asn Lys Pro Thr Tyr Phe Asp Ile Tyr Thr Ala Gly Ala 
    370                 375                 380                 


Gly Val Gly Asp Ile Gly Val Glu Val Glu Asp Pro Gln Gly Lys Asn 
385                 390                 395                 400 


Thr Val Glu Leu Leu Val Glu Asp Lys Gly Asn Gln Val Tyr Arg Cys 
                405                 410                 415     


Val Tyr Lys Pro Met Gln Pro Gly Pro His Val Val Lys Ile Phe Phe 
            420                 425                 430         


Ala Gly Asp Thr Ile Pro Lys Ser Pro Phe Val Val Gln Val Gly Glu 
        435                 440                 445             


Ala Cys Asn Pro Asn Ala Cys Arg Ala Ser Gly Arg Gly Leu Gln Pro 
    450                 455                 460                 


Lys Gly Val Arg Ile Arg Glu Thr Thr Asp Phe Lys Val Asp Thr Lys 
465                 470                 475                 480 


Ala Ala Gly Ser Gly Glu Leu Gly Val Thr Met Lys Gly Pro Lys Gly 
                485                 490                 495     


Leu Glu Glu Leu Val Lys Gln Lys Asp Phe Leu Asp Gly Val Tyr Ala 
            500                 505                 510         


Phe Glu Tyr Tyr Pro Ser Thr Pro Gly Arg Tyr Ser Ile Ala Ile Thr 
        515                 520                 525             


Trp Gly Gly His His Ile Pro Lys Ser Pro Phe Glu Val Gln Val Gly 
    530                 535                 540                 


Pro Glu Ala Gly Met Gln Lys Val Arg Ala Trp Gly Pro Gly Leu His 
545                 550                 555                 560 


Gly Gly Ile Val Gly Arg Ser Ala Asp Phe Val Val Glu Ser Ile Gly 
                565                 570                 575     


Ser Glu Val Gly Ser Leu Gly Phe Ala Ile Glu Gly Pro Ser Gln Ala 
            580                 585                 590         


Lys Ile Glu Tyr Asn Asp Gln Asn Asp Gly Ser Cys Asp Val Lys Tyr 
        595                 600                 605             


Trp Pro Lys Glu Pro Gly Glu Tyr Ala Val His Ile Met Cys Asp Asp 
    610                 615                 620                 


Glu Asp Ile Lys Asp Ser Pro Tyr Met Ala Phe Ile His Pro Ala Thr 
625                 630                 635                 640 


Gly Gly Tyr Asn Pro Asp Leu Val Arg Ala Tyr Gly Pro Gly Leu Glu 
                645                 650                 655     


Lys Ser Gly Cys Ile Val Asn Asn Leu Ala Glu Phe Thr Val Asp Pro 
            660                 665                 670         


Lys Asp Ala Gly Lys Ala Pro Leu Lys Ile Phe Ala Gln Asp Gly Glu 
        675                 680                 685             


Gly Gln Arg Ile Asp Ile Gln Met Lys Asn Arg Met Asp Gly Thr Tyr 
    690                 695                 700                 


Ala Cys Ser Tyr Thr Pro Val Lys Ala Ile Lys His Thr Ile Ala Val 
705                 710                 715                 720 


Val Trp Gly Gly Val Asn Ile Pro His Ser Pro Tyr Arg Val Asn Ile 
                725                 730                 735     


Gly Gln Gly Ser His Pro Gln Lys Val Lys Val Phe Gly Pro Gly Val 
            740                 745                 750         


Glu Arg Ser Gly Leu Lys Ala Asn Glu Pro Thr His Phe Thr Val Asp 
        755                 760                 765             


Cys Thr Glu Ala Gly Glu Gly Asp Val Ser Val Gly Ile Lys Cys Asp 
    770                 775                 780                 


Ala Arg Val Leu Ser Glu Asp Glu Glu Asp Val Asp Phe Asp Ile Ile 
785                 790                 795                 800 


His Asn Ala Asn Asp Thr Phe Thr Val Lys Tyr Val Pro Pro Ala Ala 
                805                 810                 815     


Gly Arg Tyr Thr Ile Lys Val Leu Phe Ala Ser Gln Glu Ile Pro Ala 
            820                 825                 830         


Ser Pro Phe Arg Val Lys Val Asp Pro Ser His Asp Ala Ser Lys Val 
        835                 840                 845             


Lys Ala Glu Gly Pro Gly Leu Ser Lys Ala Gly Val Glu Asn Gly Lys 
    850                 855                 860                 


Pro Thr His Phe Thr Val Tyr Thr Lys Gly Ala Gly Lys Ala Pro Leu 
865                 870                 875                 880 


Asn Val Gln Phe Asn Ser Pro Leu Pro Gly Asp Ala Val Lys Asp Leu 
                885                 890                 895     


Asp Ile Ile Asp Asn Tyr Asp Tyr Ser His Thr Val Lys Tyr Thr Pro 
            900                 905                 910         


Thr Gln Gln Gly Asn Met Gln Val Leu Val Thr Tyr Gly Gly Asp Pro 
        915                 920                 925             


Ile Pro Lys Ser Pro Phe Thr Val Gly Val Ala Ala Pro Leu Asp Leu 
    930                 935                 940                 


Ser Lys Ile Lys Leu Asn Gly Leu Glu Asn Arg Val Glu Val Gly Lys 
945                 950                 955                 960 


Asp Gln Glu Phe Thr Val Asp Thr Arg Gly Ala Gly Gly Gln Gly Lys 
                965                 970                 975     


Leu Asp Val Thr Ile Leu Ser Pro Ser Arg Lys Val Val Pro Cys Leu 
            980                 985                 990         


Val Thr Pro Val Thr Gly Arg Glu  Asn Ser Thr Ala Lys  Phe Ile Pro 
        995                 1000                 1005             


Arg Glu  Glu Gly Leu Tyr Ala  Val Asp Val Thr Tyr  Asp Gly His 
    1010                 1015                 1020             


Pro Val  Pro Gly Ser Pro Tyr  Thr Val Glu Ala Ser  Leu Pro Pro 
    1025                 1030                 1035             


Asp Pro  Ser Lys Val Lys Ala  His Gly Pro Gly Leu  Glu Gly Gly 
    1040                 1045                 1050             


Leu Val  Gly Lys Pro Ala Glu  Phe Thr Ile Asp Thr  Lys Gly Ala 
    1055                 1060                 1065             


Gly Thr  Gly Gly Leu Gly Leu  Thr Val Glu Gly Pro  Cys Glu Ala 
    1070                 1075                 1080             


Lys Ile  Glu Cys Ser Asp Asn  Gly Asp Gly Thr Cys  Ser Val Ser 
    1085                 1090                 1095             


Tyr Leu  Pro Thr Lys Pro Gly  Glu Tyr Phe Val Asn  Ile Leu Phe 
    1100                 1105                 1110             


Glu Glu  Val His Ile Pro Gly  Ser Pro Phe Lys Ala  Asp Ile Glu 
    1115                 1120                 1125             


Met Pro  Phe Asp Pro Ser Lys  Val Val Ala Ser Gly  Pro Gly Leu 
    1130                 1135                 1140             


Glu His  Gly Lys Val Gly Glu  Ala Gly Leu Leu Ser  Val Asp Cys 
    1145                 1150                 1155             


Ser Glu  Ala Gly Pro Gly Ala  Leu Gly Leu Glu Ala  Val Ser Asp 
    1160                 1165                 1170             


Ser Gly  Thr Lys Ala Glu Val  Ser Ile Gln Asn Asn  Lys Asp Gly 
    1175                 1180                 1185             


Thr Tyr  Ala Val Thr Tyr Val  Pro Leu Thr Ala Gly  Met Tyr Thr 
    1190                 1195                 1200             


Leu Thr  Met Lys Tyr Gly Gly  Glu Leu Val Pro His  Phe Pro Ala 
    1205                 1210                 1215             


Arg Val  Lys Val Glu Pro Ala  Val Asp Thr Ser Arg  Ile Lys Val 
    1220                 1225                 1230             


Phe Gly  Pro Gly Ile Glu Gly  Lys Asp Val Phe Arg  Glu Ala Thr 
    1235                 1240                 1245             


Thr Asp  Phe Thr Val Asp Ser  Arg Pro Leu Thr Gln  Val Gly Gly 
    1250                 1255                 1260             


Asp His  Ile Lys Ala His Ile  Ala Asn Pro Ser Gly  Ala Ser Thr 
    1265                 1270                 1275             


Glu Cys  Phe Val Thr Asp Asn  Ala Asp Gly Thr Tyr  Gln Val Glu 
    1280                 1285                 1290             


Tyr Thr  Pro Phe Glu Lys Gly  Leu His Val Val Glu  Val Thr Tyr 
    1295                 1300                 1305             


Asp Asp  Val Pro Ile Pro Asn  Ser Pro Phe Lys Val  Ala Val Thr 
    1310                 1315                 1320             


Glu Gly  Cys Gln Pro Ser Arg  Val Gln Ala Gln Gly  Pro Gly Leu 
    1325                 1330                 1335             


Lys Glu  Ala Phe Thr Asn Lys  Pro Asn Val Phe Thr  Val Val Thr 
    1340                 1345                 1350             


Arg Gly  Ala Gly Ile Gly Gly  Leu Gly Ile Thr Val  Glu Gly Pro 
    1355                 1360                 1365             


Ser Glu  Ser Lys Ile Asn Cys  Arg Asp Asn Lys Asp  Gly Ser Cys 
    1370                 1375                 1380             


Ser Ala  Glu Tyr Ile Pro Phe  Ala Pro Gly Asp Tyr  Asp Val Asn 
    1385                 1390                 1395             


Ile Thr  Tyr Gly Gly Ala His  Ile Pro Gly Ser Pro  Phe Arg Val 
    1400                 1405                 1410             


Pro Val  Lys Asp Val Val Asp  Pro Ser Lys Val Lys  Ile Ala Gly 
    1415                 1420                 1425             


Pro Gly  Leu Gly Ser Gly Val  Arg Ala Arg Val Leu  Gln Ser Phe 
    1430                 1435                 1440             


Thr Val  Asp Ser Ser Lys Ala  Gly Leu Ala Pro Leu  Glu Val Arg 
    1445                 1450                 1455             


Val Leu  Gly Pro Arg Gly Leu  Val Glu Pro Val Asn  Val Val Asp 
    1460                 1465                 1470             


Asn Gly  Asp Gly Thr His Thr  Val Thr Tyr Thr Pro  Ser Gln Glu 
    1475                 1480                 1485             


Gly Pro  Tyr Met Val Ser Val  Lys Tyr Ala Asp Glu  Glu Ile Pro 
    1490                 1495                 1500             


Arg Ser  Pro Phe Lys Val Lys  Val Leu Pro Thr Tyr  Asp Ala Ser 
    1505                 1510                 1515             


Lys Val  Thr Ala Ser Gly Pro  Gly Leu Ser Ser Tyr  Gly Val Pro 
    1520                 1525                 1530             


Ala Ser  Leu Pro Val Asp Phe  Ala Ile Asp Ala Arg  Asp Ala Gly 
    1535                 1540                 1545             


Glu Gly  Leu Leu Ala Val Gln  Ile Thr Asp Gln Glu  Gly Lys Pro 
    1550                 1555                 1560             


Lys Arg  Ala Ile Val His Asp  Asn Lys Asp Gly Thr  Tyr Ala Val 
    1565                 1570                 1575             


Thr Tyr  Ile Pro Asp Lys Thr  Gly Arg Tyr Met Ile  Gly Val Thr 
    1580                 1585                 1590             


Tyr Gly  Gly Asp Asp Ile Pro  Leu Ser Pro Tyr Arg  Ile Arg Ala 
    1595                 1600                 1605             


Thr Gln  Thr Gly Asp Ala Ser  Lys Cys Leu Ala Thr  Gly Pro Gly 
    1610                 1615                 1620             


Ile Ala  Ser Thr Val Lys Thr  Gly Glu Glu Val Gly  Phe Val Val 
    1625                 1630                 1635             


Asp Ala  Lys Thr Ala Gly Lys  Gly Lys Val Thr Cys  Thr Val Leu 
    1640                 1645                 1650             


Thr Pro  Asp Gly Thr Glu Ala  Glu Ala Asp Val Ile  Glu Asn Glu 
    1655                 1660                 1665             


Asp Gly  Thr Tyr Asp Ile Phe  Tyr Thr Ala Ala Lys  Pro Gly Thr 
    1670                 1675                 1680             


Tyr Val  Ile Tyr Val Arg Phe  Gly Gly Val Asp Ile  Pro Asn Ser 
    1685                 1690                 1695             


Pro Phe  Thr Val Met Ala Thr  Asp Gly Glu Val Thr  Ala Val Glu 
    1700                 1705                 1710             


Glu Ala  Pro Val Asn Ala Cys  Pro Pro Gly Phe Arg  Pro Trp Val 
    1715                 1720                 1725             


Thr Glu  Glu Ala Tyr Val Pro  Val Ser Asp Met Asn  Gly Leu Gly 
    1730                 1735                 1740             


Phe Lys  Pro Phe Asp Leu Val  Ile Pro Phe Ala Val  Arg Lys Gly 
    1745                 1750                 1755             


Glu Ile  Thr Gly Glu Val His  Met Pro Ser Gly Lys  Thr Ala Thr 
    1760                 1765                 1770             


Pro Glu  Ile Val Asp Asn Lys  Asp Gly Thr Val Thr  Val Arg Tyr 
    1775                 1780                 1785             


Ala Pro  Thr Glu Val Gly Leu  His Glu Met His Ile  Lys Tyr Met 
    1790                 1795                 1800             


Gly Ser  His Ile Pro Glu Ser  Pro Leu Gln Phe Tyr  Val Asn Tyr 
    1805                 1810                 1815             


Pro Asn  Ser Gly Ser Val Ser  Ala Tyr Gly Pro Gly  Leu Val Tyr 
    1820                 1825                 1830             


Gly Val  Ala Asn Lys Thr Ala  Thr Phe Thr Ile Val  Thr Glu Asp 
    1835                 1840                 1845             


Ala Gly  Glu Gly Gly Leu Asp  Leu Ala Ile Glu Gly  Pro Ser Lys 
    1850                 1855                 1860             


Ala Glu  Ile Ser Cys Ile Asp  Asn Lys Asp Gly Thr  Cys Thr Val 
    1865                 1870                 1875             


Thr Tyr  Leu Pro Thr Leu Pro  Gly Asp Tyr Ser Ile  Leu Val Lys 
    1880                 1885                 1890             


Tyr Asn  Asp Lys His Ile Pro  Gly Ser Pro Phe Thr  Ala Lys Ile 
    1895                 1900                 1905             


Thr Asp  Asp Ser Arg Arg Cys  Ser Gln Val Lys Leu  Gly Ser Ala 
    1910                 1915                 1920             


Ala Asp  Phe Leu Leu Asp Ile  Ser Glu Thr Asp Leu  Ser Ser Leu 
    1925                 1930                 1935             


Thr Ala  Ser Ile Lys Ala Pro  Ser Gly Arg Asp Glu  Pro Cys Leu 
    1940                 1945                 1950             


Leu Lys  Arg Leu Pro Asn Asn  His Ile Gly Ile Ser  Phe Ile Pro 
    1955                 1960                 1965             


Arg Glu  Val Gly Glu His Leu  Val Ser Ile Lys Lys  Asn Gly Asn 
    1970                 1975                 1980             


His Val  Ala Asn Ser Pro Val  Ser Ile Met Val Val  Gln Ser Glu 
    1985                 1990                 1995             


Ile Gly  Asp Ala Arg Arg Ala  Lys Val Tyr Gly Arg  Gly Leu Ser 
    2000                 2005                 2010             


Glu Gly  Arg Thr Phe Glu Met  Ser Asp Phe Ile Val  Asp Thr Arg 
    2015                 2020                 2025             


Asp Ala  Gly Tyr Gly Gly Ile  Ser Leu Ala Val Glu  Gly Pro Ser 
    2030                 2035                 2040             


Lys Val  Asp Ile Gln Thr Glu  Asp Leu Glu Asp Gly  Thr Cys Lys 
    2045                 2050                 2055             


Val Ser  Tyr Phe Pro Thr Val  Pro Gly Val Tyr Ile  Val Ser Thr 
    2060                 2065                 2070             


Lys Phe  Ala Asp Glu His Val  Pro Gly Ser Pro Phe  Thr Val Lys 
    2075                 2080                 2085             


Ile Ser  Gly Glu Gly Arg Val  Lys Glu Ser Ile Thr  Arg Thr Ser 
    2090                 2095                 2100             


Arg Ala  Pro Ser Val Ala Thr  Val Gly Ser Ile Cys  Asp Leu Asn 
    2105                 2110                 2115             


Leu Lys  Ile Pro Glu Ile Asn  Ser Ser Asp Met Ser  Ala His Val 
    2120                 2125                 2130             


Thr Ser  Pro Ser Gly Arg Val  Thr Glu Ala Glu Ile  Val Pro Met 
    2135                 2140                 2145             


Gly Lys  Asn Ser His Cys Val  Arg Phe Val Pro Gln  Glu Met Gly 
    2150                 2155                 2160             


Val His  Thr Val Ser Val Lys  Tyr Arg Gly Gln His  Val Thr Gly 
    2165                 2170                 2175             


Ser Pro  Phe Gln Phe Thr Val  Gly Pro Leu Gly Glu  Gly Gly Ala 
    2180                 2185                 2190             


His Lys  Val Arg Ala Gly Gly  Pro Gly Leu Glu Arg  Gly Glu Ala 
    2195                 2200                 2205             


Gly Val  Pro Ala Glu Phe Ser  Ile Trp Thr Arg Glu  Ala Gly Ala 
    2210                 2215                 2220             


Gly Gly  Leu Ser Ile Ala Val  Glu Gly Pro Ser Lys  Ala Glu Ile 
    2225                 2230                 2235             


Thr Phe  Asp Asp His Lys Asn  Gly Ser Cys Gly Val  Ser Tyr Ile 
    2240                 2245                 2250             


Ala Gln  Glu Pro Gly Asn Tyr  Glu Val Ser Ile Lys  Phe Asn Asp 
    2255                 2260                 2265             


Glu His  Ile Pro Glu Ser Pro  Tyr Leu Val Pro Val  Ile Ala Pro 
    2270                 2275                 2280             


Ser Asp  Asp Ala Arg Arg Leu  Thr Val Met Ser Leu  Gln Glu Ser 
    2285                 2290                 2295             


Gly Leu  Lys Val Asn Gln Pro  Ala Ser Phe Ala Ile  Arg Leu Asn 
    2300                 2305                 2310             


Gly Ala  Lys Gly Lys Ile Asp  Ala Lys Val His Ser  Pro Ser Gly 
    2315                 2320                 2325             


Ala Val  Glu Glu Cys His Val  Ser Glu Leu Glu Pro  Asp Lys Tyr 
    2330                 2335                 2340             


Ala Val  Arg Phe Ile Pro His  Glu Asn Gly Val His  Thr Ile Asp 
    2345                 2350                 2355             


Val Lys  Phe Asn Gly Ser His  Val Val Gly Ser Pro  Phe Lys Val 
    2360                 2365                 2370             


Arg Val  Gly Glu Pro Gly Gln  Ala Gly Asn Pro Ala  Leu Val Ser 
    2375                 2380                 2385             


Ala Tyr  Gly Thr Gly Leu Glu  Gly Gly Thr Thr Gly  Ile Gln Ser 
    2390                 2395                 2400             


Glu Phe  Phe Ile Asn Thr Thr  Arg Ala Gly Pro Gly  Thr Leu Ser 
    2405                 2410                 2415             


Val Thr  Ile Glu Gly Pro Ser  Lys Val Lys Met Asp  Cys Gln Glu 
    2420                 2425                 2430             


Thr Pro  Glu Gly Tyr Lys Val  Met Tyr Thr Pro Met  Ala Pro Gly 
    2435                 2440                 2445             


Asn Tyr  Leu Ile Ser Val Lys  Tyr Gly Gly Pro Asn  His Ile Val 
    2450                 2455                 2460             


Gly Ser  Pro Phe Lys Ala Lys  Val Thr Gly Gln Arg  Leu Val Ser 
    2465                 2470                 2475             


Pro Gly  Ser Ala Asn Glu Thr  Ser Ser Ile Leu Val  Glu Ser Val 
    2480                 2485                 2490             


Thr Arg  Ser Ser Thr Glu Thr  Cys Tyr Ser Ala Ile  Pro Lys Ala 
    2495                 2500                 2505             


Ser Ser  Asp Ala Ser Lys Val  Thr Ser Lys Gly Ala  Gly Leu Ser 
    2510                 2515                 2520             


Lys Ala  Phe Val Gly Gln Lys  Ser Ser Phe Leu Val  Asp Cys Ser 
    2525                 2530                 2535             


Lys Ala  Gly Ser Asn Met Leu  Leu Ile Gly Val His  Gly Pro Thr 
    2540                 2545                 2550             


Thr Pro  Cys Glu Glu Val Ser  Met Lys His Val Gly  Asn Gln Gln 
    2555                 2560                 2565             


Tyr Asn  Val Thr Tyr Val Val  Lys Glu Arg Gly Asp  Tyr Val Leu 
    2570                 2575                 2580             


Ala Val  Lys Trp Gly Glu Glu  His Ile Pro Gly Ser  Pro Phe His 
    2585                 2590                 2595             


Val Thr  Val Pro 
    2600         

<210>  132
<211>  449
<212>  DNA
<213>  Homo sapiens

<400>  132
atggcaagag tgcctcaaaa agatagggaa gtgatcattc aggggccttc ctcagtaatg     60

aaacaaataa gagctgattg gaaagcaaat agctgttgga gaccctcatc tatagtggac    120

tggaacaaag cacaggtgac tgtaacacag attgatgaaa gattctgcag gacgacaaag    180

gttaaagatg tagacccgga gctagaagcc agcactgaca ctgatggagt ggactgcgat    240

gagaatgccc acattattgt cctatcctct gataaccaat gtaatatgaa aaccgactac    300

agaagaaagg aacaaattaa atccattaat caagcatatc tctgctaaac agttgttcga    360

aactgatgaa caaatgaaaa atttactgtt tgttttcatg cttgcaagga ttggggaaga    420

aaattaatta taaggtactg gccacacta                                      449


<210>  133
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  133


Met Ala Arg Val Pro Gln Lys Asp Arg Glu Val Ile Ile Gln Gly Pro 
1               5                   10                  15      


Ser Ser Val Met Lys Gln Ile Arg Ala Asp Trp Lys Ala Asn Ser Cys 
            20                  25                  30          


Trp Arg Pro Ser Ser Ile Val Asp Trp Asn Lys Ala Gln Val Thr Val 
        35                  40                  45              


Thr Gln Ile Asp Glu Arg Phe Cys Arg Thr Thr Lys Val Lys Asp Val 
    50                  55                  60                  


Asp Pro Glu Leu Glu Ala Ser Thr Asp Thr Asp Gly Val Asp Cys Asp 
65                  70                  75                  80  


Glu Asn Ala His Ile Ile Val Leu Ser Ser Asp Asn Gln Cys Asn Met 
                85                  90                  95      


Lys Thr Asp Tyr Arg Arg Lys Glu Gln Ile Lys Ser Ile Asn Gln Ala 
            100                 105                 110         


Tyr Leu Cys 
        115 

<210>  134
<211>  5313
<212>  DNA
<213>  Homo sapiens

<400>  134
ggggagcagg cgggggagcg ggcgggaagc agtgggagcg cgcgtgcgcg cggccgtgca     60

gcctgggcag tgggtcctgc ctgtgacgcg cggcggcggt cggtcctgcc tgtaacggcg    120

gcggcggctg ctgctccaga cacctgcggc ggcggcggcg accccgcggc gggcgcggag    180

atgtggcccc tggtagcggc gctgttgctg ggctcggcgt gctgcggatc agctcagcta    240

ctatttaata aaacaaaatc tgtagaattc acgttttgta atgacactgt cgtcattcca    300

tgctttgtta ctaatatgga ggcacaaaac actactgaag tatacgtaaa gtggaaattt    360

aaaggaagag atatttacac ctttgatgga gctctaaaca agtccactgt ccccactgac    420

tttagtagtg caaaaattga agtctcacaa ttactaaaag gagatgcctc tttgaagatg    480

gataagagtg atgctgtctc acacacagga aactacactt gtgaagtaac agaattaacc    540

agagaaggtg aaacgatcat cgagctaaaa tatcgtgttg tttcatggtt ttctccaaat    600

gaaaatattc ttattgttat tttcccaatt tttgctatac tcctgttctg gggacagttt    660

ggtattaaaa cacttaaata tagatccggt ggtatggatg agaaaacaat tgctttactt    720

gttgctggac tagtgatcac tgtcattgtc attgttggag ccattctttt cgtcccaggt    780

gaatattcat taaagaatgc tactggcctt ggtttaattg tgacttctac agggatatta    840

atattacttc actactatgt gtttagtaca gcgattggat taacctcctt cgtcattgcc    900

atattggtta ttcaggtgat agcctatatc ctcgctgtgg ttggactgag tctctgtatt    960

gcggcgtgta taccaatgca tggccctctt ctgatttcag gtttgagtat cttagctcta   1020

gcacaattac ttggactagt ttatatgaaa tttgtggctt ccaatcagaa gactatacaa   1080

cctcctagga aagctgtaga ggaacccctt aatgaataac tgaagtgaag tgatggactc   1140

cgatttggag agtagtaaga cgtgaaagga atacacttgt gtttaagcac catggccttg   1200

atgattcact gttggggaga agaaacaaga aaagtaactg gttgtcacct atgagaccct   1260

tacgtgattg ttagttaagt ttttattcaa agcagctgta atttagttaa taaaataatt   1320

atgatctatg ttgtttgccc aattgagatc cagttttttg ttgttatttt taatcaatta   1380

ggggcaatag tagaatggac aatttccaag aatgatgcct ttcaggtcct agggcctctg   1440

gcctctaggt aaccagttta aattggttca gggtgataac tacttagcac tgccctggtg   1500

attacccaga gatatctatg aaaaccagtg gcttccatca aacctttgcc aactcaggtt   1560

cacagcagct ttgggcagtt atggcagtat ggcattagct gagaggtgtc tgccacttct   1620

gggtcaatgg aataataaat taagtacagg caggaatttg gttgggagca tcttgtatga   1680

tctccgtatg atgtgatatt gatggagata gtggtcctca ttcttggggg ttgccattcc   1740

cacattcccc cttcaacaaa cagtgtaaca ggtccttccc agatttaggg tacttttatt   1800

gatggatatg ttttcctttt attcacataa ccccttgaaa ccctgtcttg tcctcctgtt   1860

acttgcttct gctgtacaag atgtagcacc ttttctcctc tttgaacatg gtctagtgac   1920

acggtagcac cagttgcagg aaggagccag acttgttctc agagcactgt gttcacactt   1980

ttcagcaaaa atagctatgg ttgtaacata tgtattccct tcctctgatt tgaaggcaaa   2040

aatctacagt gtttcttcac ttcttttctg atctggggca tgaaaaaagc aagattgaaa   2100

tttgaactat gagtctcctg catggcaaca aaatgtgtgt caccatcagg ccaacaggcc   2160

agcccttgaa tggggattta ttactgttgt atctatgttg catgataaac attcatcacc   2220

ttcctcctgt agtcctgcct cgtactcccc ttcccctatg attgaaaagt aaacaaaacc   2280

cacatttcct atcctggtta gaagaaaatt aatgttctga cagttgtgat cgcctggagt   2340

acttttagac ttttagcatt cgttttttac ctgtttgtgg atgtgtgttt gtatgtgcat   2400

acgtatgaga taggcacatg catcttctgt atggacaaag gtggggtacc tacaggagag   2460

caaaggttaa ttttgtgctt ttagtaaaaa catttaaata caaagttctt tattgggtgg   2520

aattatattt gatgcaaata tttgatcact taaaactttt aaaacttcta ggtaatttgc   2580

cacgcttttt gactgctcac caataccctg taaaaatacg taattcttcc tgtttgtgta   2640

ataagatatt catatttgta gttgcattaa taatagttat ttcttagtcc atcagatgtt   2700

cccgtgtgcc tcttttatgc caaattgatt gtcatatttc atgttgggac caagtagttt   2760

gcccatggca aacctaaatt tatgacctgc tgaggcctct cagaaaactg agcatactag   2820

caagacagct cttcttgaaa aaaaaaatat gtatacacaa atatatacgt atatctatat   2880

atacgtatgt atatacacac atgtatattc ttccttgatt gtgtagctgt ccaaaataat   2940

aacatatata gagggagctg tattccttta tacaaatctg atggctcctg cagcactttt   3000

tccttctgaa aatatttaca ttttgctaac ctagtttgtt actttaaaaa tcagttttga   3060

tgaaaggagg gaaaagcaga tggacttgaa aaagatccaa gctcctatta gaaaaggtat   3120

gaaaatcttt atagtaaaat tttttataaa ctaaagttgt accttttaat atgtagtaaa   3180

ctctcattta tttggggttc gctcttggat ctcatccatc cattgtgttc tctttaatgc   3240

tgcctgcctt ttgaggcatt cactgcccta gacaatgcca ccagagatag tgggggaaat   3300

gccagatgaa accaactctt gctctcacta gttgtcagct tctctggata agtgaccaca   3360

gaagcaggag tcctcctgct tgggcatcat tgggccagtt ccttctcttt aaatcagatt   3420

tgtaatggct cccaaattcc atcacatcac atttaaattg cagacagtgt tttgcacatc   3480

atgtatctgt tttgtcccat aatatgcttt ttactccctg atcccagttt ctgctgttga   3540

ctcttccatt cagttttatt tattgtgtgt tctcacagtg acaccatttg tccttttctg   3600

caacaacctt tccagctact tttgccaaat tctatttgtc ttctccttca aaacattctc   3660

ctttgcagtt cctcttcatc tgtgtagctg ctcttttgtc tcttaactta ccattcctat   3720

agtactttat gcatctctgc ttagttctat tagttttttg gccttgctct tctccttgat   3780

tttaaaattc cttctatagc tagagctttt ctttctttca ttctctcttc ctgcagtgtt   3840

ttgcatacat cagaagctag gtacataagt taaatgattg agagttggct gtatttagat   3900

ttatcacttt ttaatagggt gagcttgaga gttttctttc tttctgtttt ttttttttgt   3960

tttttttttt tttttttttt tttttttttt tgactaattt cacatgctct aaaaaccttc   4020

aaaggtgatt atttttctcc tggaaactcc aggtccattc tgtttaaatc cctaagaatg   4080

tcagaattaa aataacaggg ctatcccgta attggaaata tttctttttt caggatgcta   4140

tagtcaattt agtaagtgac caccaaattg ttatttgcac taacaaagct caaaacacga   4200

taagtttact cctccatctc agtaataaaa attaagctgt aatcaacctt ctaggtttct   4260

cttgtcttaa aatgggtatt caaaaatggg gatctgtggt gtatgtatgg aaacacatac   4320

tccttaattt acctgttgtt ggaaactgga gaaatgattg tcgggcaacc gtttattttt   4380

tattgtattt tatttggttg agggattttt ttataaacag ttttacttgt gtcatatttt   4440

aaaattacta actgccatca cctgctgggg tcctttgtta ggtcattttc agtgactaat   4500

agggataatc caggtaactt tgaagagatg agcagtgagt gaccaggcag tttttctgcc   4560

tttagctttg acagttctta attaagatca ttgaagacca gctttctcat aaatttctct   4620

ttttgaaaaa aagaaagcat ttgtactaag ctcctctgta agacaacatc ttaaatctta   4680

aaagtgttgt tatcatgact ggtgagagaa gaaaacattt tgtttttatt aaatggagca   4740

ttatttacaa aaagccattg ttgagaatta gatcccacat cgtataaata tctattaacc   4800

attctaaata aagagaactc cagtgttgct atgtgcaaga tcctctcttg gagctttttt   4860

gcatagcaat taaaggtgtg ctatttgtca gtagccattt ttttgcagtg atttgaagac   4920

caaagttgtt ttacagctgt gttaccgtta aaggtttttt tttttatatg tattaaatca   4980

atttatcact gtttaaagct ttgaatatct gcaatctttg ccaaggtact tttttattta   5040

aaaaaaaaca taactttgta aatattaccc tgtaatatta tatatactta ataaaacatt   5100

ttaagctatt ttgttgggct atttctattg ctgctacagc agaccacaag cacatttctg   5160

aaaaatttaa tttattaatg tatttttaag ttgcttatat tctaggtaac aatgtaaaga   5220

atgatttaaa atattaatta tgaatttttt gagtataata cccaataagc ttttaattag   5280

agcagagttt taattaaaag ttttaaatca gtc                                5313


<210>  135
<211>  312
<212>  PRT
<213>  Homo sapiens

<400>  135


Met Trp Pro Leu Val Ala Ala Leu Leu Leu Gly Ser Ala Cys Cys Gly 
1               5                   10                  15      


Ser Ala Gln Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe 
            20                  25                  30          


Cys Asn Asp Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala 
        35                  40                  45              


Gln Asn Thr Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp 
    50                  55                  60                  


Ile Tyr Thr Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp 
65                  70                  75                  80  


Phe Ser Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala 
                85                  90                  95      


Ser Leu Lys Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr 
            100                 105                 110         


Thr Cys Glu Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu 
        115                 120                 125             


Leu Lys Tyr Arg Val Val Ser Trp Phe Ser Pro Asn Glu Asn Ile Leu 
    130                 135                 140                 


Ile Val Ile Phe Pro Ile Phe Ala Ile Leu Leu Phe Trp Gly Gln Phe 
145                 150                 155                 160 


Gly Ile Lys Thr Leu Lys Tyr Arg Ser Gly Gly Met Asp Glu Lys Thr 
                165                 170                 175     


Ile Ala Leu Leu Val Ala Gly Leu Val Ile Thr Val Ile Val Ile Val 
            180                 185                 190         


Gly Ala Ile Leu Phe Val Pro Gly Glu Tyr Ser Leu Lys Asn Ala Thr 
        195                 200                 205             


Gly Leu Gly Leu Ile Val Thr Ser Thr Gly Ile Leu Ile Leu Leu His 
    210                 215                 220                 


Tyr Tyr Val Phe Ser Thr Ala Ile Gly Leu Thr Ser Phe Val Ile Ala 
225                 230                 235                 240 


Ile Leu Val Ile Gln Val Ile Ala Tyr Ile Leu Ala Val Val Gly Leu 
                245                 250                 255     


Ser Leu Cys Ile Ala Ala Cys Ile Pro Met His Gly Pro Leu Leu Ile 
            260                 265                 270         


Ser Gly Leu Ser Ile Leu Ala Leu Ala Gln Leu Leu Gly Leu Val Tyr 
        275                 280                 285             


Met Lys Phe Val Ala Ser Asn Gln Lys Thr Ile Gln Pro Pro Arg Lys 
    290                 295                 300                 


Ala Val Glu Glu Pro Leu Asn Glu 
305                 310         

<210>  136
<211>  5346
<212>  DNA
<213>  Homo sapiens

<400>  136
ggggagcagg cgggggagcg ggcgggaagc agtgggagcg cgcgtgcgcg cggccgtgca     60

gcctgggcag tgggtcctgc ctgtgacgcg cggcggcggt cggtcctgcc tgtaacggcg    120

gcggcggctg ctgctccaga cacctgcggc ggcggcggcg accccgcggc gggcgcggag    180

atgtggcccc tggtagcggc gctgttgctg ggctcggcgt gctgcggatc agctcagcta    240

ctatttaata aaacaaaatc tgtagaattc acgttttgta atgacactgt cgtcattcca    300

tgctttgtta ctaatatgga ggcacaaaac actactgaag tatacgtaaa gtggaaattt    360

aaaggaagag atatttacac ctttgatgga gctctaaaca agtccactgt ccccactgac    420

tttagtagtg caaaaattga agtctcacaa ttactaaaag gagatgcctc tttgaagatg    480

gataagagtg atgctgtctc acacacagga aactacactt gtgaagtaac agaattaacc    540

agagaaggtg aaacgatcat cgagctaaaa tatcgtgttg tttcatggtt ttctccaaat    600

gaaaatattc ttattgttat tttcccaatt tttgctatac tcctgttctg gggacagttt    660

ggtattaaaa cacttaaata tagatccggt ggtatggatg agaaaacaat tgctttactt    720

gttgctggac tagtgatcac tgtcattgtc attgttggag ccattctttt cgtcccaggt    780

gaatattcat taaagaatgc tactggcctt ggtttaattg tgacttctac agggatatta    840

atattacttc actactatgt gtttagtaca gcgattggat taacctcctt cgtcattgcc    900

atattggtta ttcaggtgat agcctatatc ctcgctgtgg ttggactgag tctctgtatt    960

gcggcgtgta taccaatgca tggccctctt ctgatttcag gtttgagtat cttagctcta   1020

gcacaattac ttggactagt ttatatgaaa tttgtggctt ccaatcagaa gactatacaa   1080

cctcctagga aagctgtaga ggaacccctt aatgcattca aagaatcaaa aggaatgatg   1140

aatgatgaat aactgaagtg aagtgatgga ctccgatttg gagagtagta agacgtgaaa   1200

ggaatacact tgtgtttaag caccatggcc ttgatgattc actgttgggg agaagaaaca   1260

agaaaagtaa ctggttgtca cctatgagac ccttacgtga ttgttagtta agtttttatt   1320

caaagcagct gtaatttagt taataaaata attatgatct atgttgtttg cccaattgag   1380

atccagtttt ttgttgttat ttttaatcaa ttaggggcaa tagtagaatg gacaatttcc   1440

aagaatgatg cctttcaggt cctagggcct ctggcctcta ggtaaccagt ttaaattggt   1500

tcagggtgat aactacttag cactgccctg gtgattaccc agagatatct atgaaaacca   1560

gtggcttcca tcaaaccttt gccaactcag gttcacagca gctttgggca gttatggcag   1620

tatggcatta gctgagaggt gtctgccact tctgggtcaa tggaataata aattaagtac   1680

aggcaggaat ttggttggga gcatcttgta tgatctccgt atgatgtgat attgatggag   1740

atagtggtcc tcattcttgg gggttgccat tcccacattc ccccttcaac aaacagtgta   1800

acaggtcctt cccagattta gggtactttt attgatggat atgttttcct tttattcaca   1860

taaccccttg aaaccctgtc ttgtcctcct gttacttgct tctgctgtac aagatgtagc   1920

accttttctc ctctttgaac atggtctagt gacacggtag caccagttgc aggaaggagc   1980

cagacttgtt ctcagagcac tgtgttcaca cttttcagca aaaatagcta tggttgtaac   2040

atatgtattc ccttcctctg atttgaaggc aaaaatctac agtgtttctt cacttctttt   2100

ctgatctggg gcatgaaaaa agcaagattg aaatttgaac tatgagtctc ctgcatggca   2160

acaaaatgtg tgtcaccatc aggccaacag gccagccctt gaatggggat ttattactgt   2220

tgtatctatg ttgcatgata aacattcatc accttcctcc tgtagtcctg cctcgtactc   2280

cccttcccct atgattgaaa agtaaacaaa acccacattt cctatcctgg ttagaagaaa   2340

attaatgttc tgacagttgt gatcgcctgg agtactttta gacttttagc attcgttttt   2400

tacctgtttg tggatgtgtg tttgtatgtg catacgtatg agataggcac atgcatcttc   2460

tgtatggaca aaggtggggt acctacagga gagcaaaggt taattttgtg cttttagtaa   2520

aaacatttaa atacaaagtt ctttattggg tggaattata tttgatgcaa atatttgatc   2580

acttaaaact tttaaaactt ctaggtaatt tgccacgctt tttgactgct caccaatacc   2640

ctgtaaaaat acgtaattct tcctgtttgt gtaataagat attcatattt gtagttgcat   2700

taataatagt tatttcttag tccatcagat gttcccgtgt gcctctttta tgccaaattg   2760

attgtcatat ttcatgttgg gaccaagtag tttgcccatg gcaaacctaa atttatgacc   2820

tgctgaggcc tctcagaaaa ctgagcatac tagcaagaca gctcttcttg aaaaaaaaaa   2880

tatgtataca caaatatata cgtatatcta tatatacgta tgtatataca cacatgtata   2940

ttcttccttg attgtgtagc tgtccaaaat aataacatat atagagggag ctgtattcct   3000

ttatacaaat ctgatggctc ctgcagcact ttttccttct gaaaatattt acattttgct   3060

aacctagttt gttactttaa aaatcagttt tgatgaaagg agggaaaagc agatggactt   3120

gaaaaagatc caagctccta ttagaaaagg tatgaaaatc tttatagtaa aattttttat   3180

aaactaaagt tgtacctttt aatatgtagt aaactctcat ttatttgggg ttcgctcttg   3240

gatctcatcc atccattgtg ttctctttaa tgctgcctgc cttttgaggc attcactgcc   3300

ctagacaatg ccaccagaga tagtggggga aatgccagat gaaaccaact cttgctctca   3360

ctagttgtca gcttctctgg ataagtgacc acagaagcag gagtcctcct gcttgggcat   3420

cattgggcca gttccttctc tttaaatcag atttgtaatg gctcccaaat tccatcacat   3480

cacatttaaa ttgcagacag tgttttgcac atcatgtatc tgttttgtcc cataatatgc   3540

tttttactcc ctgatcccag tttctgctgt tgactcttcc attcagtttt atttattgtg   3600

tgttctcaca gtgacaccat ttgtcctttt ctgcaacaac ctttccagct acttttgcca   3660

aattctattt gtcttctcct tcaaaacatt ctcctttgca gttcctcttc atctgtgtag   3720

ctgctctttt gtctcttaac ttaccattcc tatagtactt tatgcatctc tgcttagttc   3780

tattagtttt ttggccttgc tcttctcctt gattttaaaa ttccttctat agctagagct   3840

tttctttctt tcattctctc ttcctgcagt gttttgcata catcagaagc taggtacata   3900

agttaaatga ttgagagttg gctgtattta gatttatcac tttttaatag ggtgagcttg   3960

agagttttct ttctttctgt tttttttttt tgtttttttt tttttttttt tttttttttt   4020

ttttgactaa tttcacatgc tctaaaaacc ttcaaaggtg attatttttc tcctggaaac   4080

tccaggtcca ttctgtttaa atccctaaga atgtcagaat taaaataaca gggctatccc   4140

gtaattggaa atatttcttt tttcaggatg ctatagtcaa tttagtaagt gaccaccaaa   4200

ttgttatttg cactaacaaa gctcaaaaca cgataagttt actcctccat ctcagtaata   4260

aaaattaagc tgtaatcaac cttctaggtt tctcttgtct taaaatgggt attcaaaaat   4320

ggggatctgt ggtgtatgta tggaaacaca tactccttaa tttacctgtt gttggaaact   4380

ggagaaatga ttgtcgggca accgtttatt ttttattgta ttttatttgg ttgagggatt   4440

tttttataaa cagttttact tgtgtcatat tttaaaatta ctaactgcca tcacctgctg   4500

gggtcctttg ttaggtcatt ttcagtgact aatagggata atccaggtaa ctttgaagag   4560

atgagcagtg agtgaccagg cagtttttct gcctttagct ttgacagttc ttaattaaga   4620

tcattgaaga ccagctttct cataaatttc tctttttgaa aaaaagaaag catttgtact   4680

aagctcctct gtaagacaac atcttaaatc ttaaaagtgt tgttatcatg actggtgaga   4740

gaagaaaaca ttttgttttt attaaatgga gcattattta caaaaagcca ttgttgagaa   4800

ttagatccca catcgtataa atatctatta accattctaa ataaagagaa ctccagtgtt   4860

gctatgtgca agatcctctc ttggagcttt tttgcatagc aattaaaggt gtgctatttg   4920

tcagtagcca tttttttgca gtgatttgaa gaccaaagtt gttttacagc tgtgttaccg   4980

ttaaaggttt ttttttttat atgtattaaa tcaatttatc actgtttaaa gctttgaata   5040

tctgcaatct ttgccaaggt acttttttat ttaaaaaaaa acataacttt gtaaatatta   5100

ccctgtaata ttatatatac ttaataaaac attttaagct attttgttgg gctatttcta   5160

ttgctgctac agcagaccac aagcacattt ctgaaaaatt taatttatta atgtattttt   5220

aagttgctta tattctaggt aacaatgtaa agaatgattt aaaatattaa ttatgaattt   5280

tttgagtata atacccaata agcttttaat tagagcagag ttttaattaa aagttttaaa   5340

tcagtc                                                              5346


<210>  137
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  137


Met Trp Pro Leu Val Ala Ala Leu Leu Leu Gly Ser Ala Cys Cys Gly 
1               5                   10                  15      


Ser Ala Gln Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe 
            20                  25                  30          


Cys Asn Asp Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala 
        35                  40                  45              


Gln Asn Thr Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp 
    50                  55                  60                  


Ile Tyr Thr Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp 
65                  70                  75                  80  


Phe Ser Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala 
                85                  90                  95      


Ser Leu Lys Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr 
            100                 105                 110         


Thr Cys Glu Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu 
        115                 120                 125             


Leu Lys Tyr Arg Val Val Ser Trp Phe Ser Pro Asn Glu Asn Ile Leu 
    130                 135                 140                 


Ile Val Ile Phe Pro Ile Phe Ala Ile Leu Leu Phe Trp Gly Gln Phe 
145                 150                 155                 160 


Gly Ile Lys Thr Leu Lys Tyr Arg Ser Gly Gly Met Asp Glu Lys Thr 
                165                 170                 175     


Ile Ala Leu Leu Val Ala Gly Leu Val Ile Thr Val Ile Val Ile Val 
            180                 185                 190         


Gly Ala Ile Leu Phe Val Pro Gly Glu Tyr Ser Leu Lys Asn Ala Thr 
        195                 200                 205             


Gly Leu Gly Leu Ile Val Thr Ser Thr Gly Ile Leu Ile Leu Leu His 
    210                 215                 220                 


Tyr Tyr Val Phe Ser Thr Ala Ile Gly Leu Thr Ser Phe Val Ile Ala 
225                 230                 235                 240 


Ile Leu Val Ile Gln Val Ile Ala Tyr Ile Leu Ala Val Val Gly Leu 
                245                 250                 255     


Ser Leu Cys Ile Ala Ala Cys Ile Pro Met His Gly Pro Leu Leu Ile 
            260                 265                 270         


Ser Gly Leu Ser Ile Leu Ala Leu Ala Gln Leu Leu Gly Leu Val Tyr 
        275                 280                 285             


Met Lys Phe Val Ala Ser Asn Gln Lys Thr Ile Gln Pro Pro Arg Lys 
    290                 295                 300                 


Ala Val Glu Glu Pro Leu Asn Ala Phe Lys Glu Ser Lys Gly Met Met 
305                 310                 315                 320 


Asn Asp Glu 
            

<210>  138
<211>  5288
<212>  DNA
<213>  Homo sapiens

<400>  138
ggggagcagg cgggggagcg ggcgggaagc agtgggagcg cgcgtgcgcg cggccgtgca     60

gcctgggcag tgggtcctgc ctgtgacgcg cggcggcggt cggtcctgcc tgtaacggcg    120

gcggcggctg ctgctccaga cacctgcggc ggcggcggcg accccgcggc gggcgcggag    180

atgtggcccc tggtagcggc gctgttgctg ggctcggcgt gctgcggatc agctcagcta    240

ctatttaata aaacaaaatc tgtagaattc acgttttgta atgacactgt cgtcattcca    300

tgctttgtta ctaatatgga ggcacaaaac actactgaag tatacgtaaa gtggaaattt    360

aaaggaagag atatttacac ctttgatgga gctctaaaca agtccactgt ccccactgac    420

tttagtagtg caaaaattga agtctcacaa ttactaaaag gagatgcctc tttgaagatg    480

gataagagtg atgctgtctc acacacagga aactacactt gtgaagtaac agaattaacc    540

agagaaggtg aaacgatcat cgagctaaaa tatcgtgttg tttcatggtt ttctccaaat    600

gaaaatattc ttattgttat tttcccaatt tttgctatac tcctgttctg gggacagttt    660

ggtattaaaa cacttaaata tagatccggt ggtatggatg agaaaacaat tgctttactt    720

gttgctggac tagtgatcac tgtcattgtc attgttggag ccattctttt cgtcccaggt    780

gaatattcat taaagaatgc tactggcctt ggtttaattg tgacttctac agggatatta    840

atattacttc actactatgt gtttagtaca gcgattggat taacctcctt cgtcattgcc    900

atattggtta ttcaggtgat agcctatatc ctcgctgtgg ttggactgag tctctgtatt    960

gcggcgtgta taccaatgca tggccctctt ctgatttcag gtttgagtat cttagctcta   1020

gcacaattac ttggactagt ttatatgaaa tttgtggctt ccaatcagaa gactatacaa   1080

cctcctagga ataactgaag tgaagtgatg gactccgatt tggagagtag taagacgtga   1140

aaggaataca cttgtgttta agcaccatgg ccttgatgat tcactgttgg ggagaagaaa   1200

caagaaaagt aactggttgt cacctatgag acccttacgt gattgttagt taagttttta   1260

ttcaaagcag ctgtaattta gttaataaaa taattatgat ctatgttgtt tgcccaattg   1320

agatccagtt ttttgttgtt atttttaatc aattaggggc aatagtagaa tggacaattt   1380

ccaagaatga tgcctttcag gtcctagggc ctctggcctc taggtaacca gtttaaattg   1440

gttcagggtg ataactactt agcactgccc tggtgattac ccagagatat ctatgaaaac   1500

cagtggcttc catcaaacct ttgccaactc aggttcacag cagctttggg cagttatggc   1560

agtatggcat tagctgagag gtgtctgcca cttctgggtc aatggaataa taaattaagt   1620

acaggcagga atttggttgg gagcatcttg tatgatctcc gtatgatgtg atattgatgg   1680

agatagtggt cctcattctt gggggttgcc attcccacat tcccccttca acaaacagtg   1740

taacaggtcc ttcccagatt tagggtactt ttattgatgg atatgttttc cttttattca   1800

cataacccct tgaaaccctg tcttgtcctc ctgttacttg cttctgctgt acaagatgta   1860

gcaccttttc tcctctttga acatggtcta gtgacacggt agcaccagtt gcaggaagga   1920

gccagacttg ttctcagagc actgtgttca cacttttcag caaaaatagc tatggttgta   1980

acatatgtat tcccttcctc tgatttgaag gcaaaaatct acagtgtttc ttcacttctt   2040

ttctgatctg gggcatgaaa aaagcaagat tgaaatttga actatgagtc tcctgcatgg   2100

caacaaaatg tgtgtcacca tcaggccaac aggccagccc ttgaatgggg atttattact   2160

gttgtatcta tgttgcatga taaacattca tcaccttcct cctgtagtcc tgcctcgtac   2220

tccccttccc ctatgattga aaagtaaaca aaacccacat ttcctatcct ggttagaaga   2280

aaattaatgt tctgacagtt gtgatcgcct ggagtacttt tagactttta gcattcgttt   2340

tttacctgtt tgtggatgtg tgtttgtatg tgcatacgta tgagataggc acatgcatct   2400

tctgtatgga caaaggtggg gtacctacag gagagcaaag gttaattttg tgcttttagt   2460

aaaaacattt aaatacaaag ttctttattg ggtggaatta tatttgatgc aaatatttga   2520

tcacttaaaa cttttaaaac ttctaggtaa tttgccacgc tttttgactg ctcaccaata   2580

ccctgtaaaa atacgtaatt cttcctgttt gtgtaataag atattcatat ttgtagttgc   2640

attaataata gttatttctt agtccatcag atgttcccgt gtgcctcttt tatgccaaat   2700

tgattgtcat atttcatgtt gggaccaagt agtttgccca tggcaaacct aaatttatga   2760

cctgctgagg cctctcagaa aactgagcat actagcaaga cagctcttct tgaaaaaaaa   2820

aatatgtata cacaaatata tacgtatatc tatatatacg tatgtatata cacacatgta   2880

tattcttcct tgattgtgta gctgtccaaa ataataacat atatagaggg agctgtattc   2940

ctttatacaa atctgatggc tcctgcagca ctttttcctt ctgaaaatat ttacattttg   3000

ctaacctagt ttgttacttt aaaaatcagt tttgatgaaa ggagggaaaa gcagatggac   3060

ttgaaaaaga tccaagctcc tattagaaaa ggtatgaaaa tctttatagt aaaatttttt   3120

ataaactaaa gttgtacctt ttaatatgta gtaaactctc atttatttgg ggttcgctct   3180

tggatctcat ccatccattg tgttctcttt aatgctgcct gccttttgag gcattcactg   3240

ccctagacaa tgccaccaga gatagtgggg gaaatgccag atgaaaccaa ctcttgctct   3300

cactagttgt cagcttctct ggataagtga ccacagaagc aggagtcctc ctgcttgggc   3360

atcattgggc cagttccttc tctttaaatc agatttgtaa tggctcccaa attccatcac   3420

atcacattta aattgcagac agtgttttgc acatcatgta tctgttttgt cccataatat   3480

gctttttact ccctgatccc agtttctgct gttgactctt ccattcagtt ttatttattg   3540

tgtgttctca cagtgacacc atttgtcctt ttctgcaaca acctttccag ctacttttgc   3600

caaattctat ttgtcttctc cttcaaaaca ttctcctttg cagttcctct tcatctgtgt   3660

agctgctctt ttgtctctta acttaccatt cctatagtac tttatgcatc tctgcttagt   3720

tctattagtt ttttggcctt gctcttctcc ttgattttaa aattccttct atagctagag   3780

cttttctttc tttcattctc tcttcctgca gtgttttgca tacatcagaa gctaggtaca   3840

taagttaaat gattgagagt tggctgtatt tagatttatc actttttaat agggtgagct   3900

tgagagtttt ctttctttct gttttttttt tttgtttttt tttttttttt tttttttttt   3960

ttttttgact aatttcacat gctctaaaaa ccttcaaagg tgattatttt tctcctggaa   4020

actccaggtc cattctgttt aaatccctaa gaatgtcaga attaaaataa cagggctatc   4080

ccgtaattgg aaatatttct tttttcagga tgctatagtc aatttagtaa gtgaccacca   4140

aattgttatt tgcactaaca aagctcaaaa cacgataagt ttactcctcc atctcagtaa   4200

taaaaattaa gctgtaatca accttctagg tttctcttgt cttaaaatgg gtattcaaaa   4260

atggggatct gtggtgtatg tatggaaaca catactcctt aatttacctg ttgttggaaa   4320

ctggagaaat gattgtcggg caaccgttta ttttttattg tattttattt ggttgaggga   4380

tttttttata aacagtttta cttgtgtcat attttaaaat tactaactgc catcacctgc   4440

tggggtcctt tgttaggtca ttttcagtga ctaataggga taatccaggt aactttgaag   4500

agatgagcag tgagtgacca ggcagttttt ctgcctttag ctttgacagt tcttaattaa   4560

gatcattgaa gaccagcttt ctcataaatt tctctttttg aaaaaaagaa agcatttgta   4620

ctaagctcct ctgtaagaca acatcttaaa tcttaaaagt gttgttatca tgactggtga   4680

gagaagaaaa cattttgttt ttattaaatg gagcattatt tacaaaaagc cattgttgag   4740

aattagatcc cacatcgtat aaatatctat taaccattct aaataaagag aactccagtg   4800

ttgctatgtg caagatcctc tcttggagct tttttgcata gcaattaaag gtgtgctatt   4860

tgtcagtagc catttttttg cagtgatttg aagaccaaag ttgttttaca gctgtgttac   4920

cgttaaaggt tttttttttt atatgtatta aatcaattta tcactgttta aagctttgaa   4980

tatctgcaat ctttgccaag gtactttttt atttaaaaaa aaacataact ttgtaaatat   5040

taccctgtaa tattatatat acttaataaa acattttaag ctattttgtt gggctatttc   5100

tattgctgct acagcagacc acaagcacat ttctgaaaaa tttaatttat taatgtattt   5160

ttaagttgct tatattctag gtaacaatgt aaagaatgat ttaaaatatt aattatgaat   5220

tttttgagta taatacccaa taagctttta attagagcag agttttaatt aaaagtttta   5280

aatcagtc                                                            5288


<210>  139
<211>  305
<212>  PRT
<213>  Homo sapiens

<400>  139


Met Trp Pro Leu Val Ala Ala Leu Leu Leu Gly Ser Ala Cys Cys Gly 
1               5                   10                  15      


Ser Ala Gln Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe 
            20                  25                  30          


Cys Asn Asp Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala 
        35                  40                  45              


Gln Asn Thr Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp 
    50                  55                  60                  


Ile Tyr Thr Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp 
65                  70                  75                  80  


Phe Ser Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala 
                85                  90                  95      


Ser Leu Lys Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr 
            100                 105                 110         


Thr Cys Glu Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu 
        115                 120                 125             


Leu Lys Tyr Arg Val Val Ser Trp Phe Ser Pro Asn Glu Asn Ile Leu 
    130                 135                 140                 


Ile Val Ile Phe Pro Ile Phe Ala Ile Leu Leu Phe Trp Gly Gln Phe 
145                 150                 155                 160 


Gly Ile Lys Thr Leu Lys Tyr Arg Ser Gly Gly Met Asp Glu Lys Thr 
                165                 170                 175     


Ile Ala Leu Leu Val Ala Gly Leu Val Ile Thr Val Ile Val Ile Val 
            180                 185                 190         


Gly Ala Ile Leu Phe Val Pro Gly Glu Tyr Ser Leu Lys Asn Ala Thr 
        195                 200                 205             


Gly Leu Gly Leu Ile Val Thr Ser Thr Gly Ile Leu Ile Leu Leu His 
    210                 215                 220                 


Tyr Tyr Val Phe Ser Thr Ala Ile Gly Leu Thr Ser Phe Val Ile Ala 
225                 230                 235                 240 


Ile Leu Val Ile Gln Val Ile Ala Tyr Ile Leu Ala Val Val Gly Leu 
                245                 250                 255     


Ser Leu Cys Ile Ala Ala Cys Ile Pro Met His Gly Pro Leu Leu Ile 
            260                 265                 270         


Ser Gly Leu Ser Ile Leu Ala Leu Ala Gln Leu Leu Gly Leu Val Tyr 
        275                 280                 285             


Met Lys Phe Val Ala Ser Asn Gln Lys Thr Ile Gln Pro Pro Arg Asn 
    290                 295                 300                 


Asn 
305 

<210>  140
<211>  2689
<212>  DNA
<213>  Homo sapiens

<400>  140
agttctcttc aagtcatgta atcgactttt ttgaattagt tttcagtttc attttgtttt     60

ccctaattca agttgggaac acttcatttt ccccaattca agttgggaac acttccttgg    120

tatttccttg ctacatggac tttagcaaat gctactttac tctccttcca gctactcagg    180

aggctgaggc aggagaatcg cttgaacccg ggaggcggag gttacagtga gccttttcct    240

agttttactg ttggaagcct aactcacagg agagattatg caatacagtc ctgaagtcaa    300

ggaaggagag catgtaggag aatactaacc ctgcacagat tgtgatggtg atgtggaata    360

tactaaagcc tagaacgcac ctcctctgca tgactaatat gttctgcaca agacatgaag    420

gcacagacag cactgtcttt cttcctcatt ctcataacat ctctgagtgg atctcaaggc    480

atattccctt tggctttctt catttatgtt cctatgaatg aacaaatcgt cattggaaga    540

cttgatgaag atataattct cccttcttca tttgagaggg gatccgaagt cgtaatacac    600

tggaagtatc aagatagcta taaggttcat agttactaca aaggcagtga ccatttggaa    660

agccaagatc ccagatatgc aaacaggaca tcccttttct ataatgagat tcaaaatggg    720

aatgcgtcac tatttttcag aagagtaagc cttctggacg aaggaattta cacctgctat    780

gtaggaacag caattcaagt gattacaaac aaagtggtgc taaaggtggg agtttttctc    840

acacccgtga tgaagtatga aaagaggaac acaaacagct tcttaatatg cagcgtgtta    900

agtgtttatc ctcgtccaat tatcacgtgg aaaatggaca acacacctat ctctgaaaac    960

aacatggaag aaacagggtc tttggattct ttttctatta acagcccact gaatattaca   1020

ggatcaaatt catcttatga atgtacaatt gaaaattcac tgctgaagca aacatggaca   1080

gggcgctgga cgatgaaaga tggccttcat aaaatgcaaa gtgaacacgt ttcactctca   1140

tgtcaacctg taaatgatta tttttcacca aaccaagact tcaaagttac ttggtccaga   1200

atgaaaagtg ggactttctc tgtcctggct tactatctga gctcctcaca aaatacaatt   1260

atcaatgaat cccgattctc atggaacaaa gagctgataa accagagtga cttctctatg   1320

aatttgatgg atcttaatct ttcagacagt ggggaatatt tatgcaatat ttcttcggat   1380

gaatatactt tacttaccat ccacacagtg catgtagaac cgagccaaga aacagcttcc   1440

cataacaaag gcttatggat tttggtgccc tctgcgattt tggcagcttt tctgctgatt   1500

tggagcgtaa aatgttgcag agcccagcta gaagccagga ggagcagaca ccctgctgat   1560

ggagcccaac aagaaagatg ttgtgtccct cctggtgagc gctgtcccag tgcacccgat   1620

aatggcgaag aaaatgtgcc tctttcagga aaagtatagg aaatgagaga agactgtgac   1680

aactcatgac ctgcatcctt aatatccagt gacttcatct cccctttctt caccacaatt   1740

ccaggcaatg gcctgtcgga ccagacaatt ctaccactgc aaagagttgt aaccattttc   1800

tggtatcaca tttatttttc aagacatact tttcaagaca tcattcactg acccactacc   1860

tgcattgagt ataaatgcct ggatgttaag gattccaatt taactttgaa aagaactgtc   1920

tcattcattt acatttctgt tacagtcagc ccaggaggtt acagtgagct ctccactaag   1980

aatctggaag aaatgcatca ctaggggttg attcccaatc tgatcaactg ataatgggtg   2040

agagagcagg taagagccaa agtcacctta gtggaaaggt taaaaaccag agcctggaaa   2100

ccaagatgat tgatttgaca aggtatttta gtctagtttt atatgaacgg ttgtatcagg   2160

gtaaccaact cgatttggga tgaatcttag ggcaccaaag actaagacag tatctttaag   2220

attgctaggg aaaagggccc tatgtgtcag gcctctgagc ccaagccaag catcgcatcc   2280

cctgtgattt gcacgtatac atccagatgg cctaaagtaa ctgaagatcc acaaaagaag   2340

taaaaatagc cttaactgat gacattccac cattgtgatt tgttcctgcc ccaccctaac   2400

tgatcaatgt actttgtaat ctcccccacc cttaagaagg tactttgtaa tcttccccac   2460

ccttaagaag gttctttgta attctcccca cccttgagaa tgtactttgt gagatccacc   2520

ctgcccacaa aacattgctc ttaacttcac cgcctaaccc aaaacctata agaactaatg   2580

ataatccatc acccttcgct gactctcttt tcggactcag cccacctgca cccaggtgaa   2640

ataaacagct ttattgctca aaaaaaaaaa aaaaaaaaaa aaaaaaaaa               2689


<210>  141
<211>  414
<212>  PRT
<213>  Homo sapiens

<400>  141


Met Lys Ala Gln Thr Ala Leu Ser Phe Phe Leu Ile Leu Ile Thr Ser 
1               5                   10                  15      


Leu Ser Gly Ser Gln Gly Ile Phe Pro Leu Ala Phe Phe Ile Tyr Val 
            20                  25                  30          


Pro Met Asn Glu Gln Ile Val Ile Gly Arg Leu Asp Glu Asp Ile Ile 
        35                  40                  45              


Leu Pro Ser Ser Phe Glu Arg Gly Ser Glu Val Val Ile His Trp Lys 
    50                  55                  60                  


Tyr Gln Asp Ser Tyr Lys Val His Ser Tyr Tyr Lys Gly Ser Asp His 
65                  70                  75                  80  


Leu Glu Ser Gln Asp Pro Arg Tyr Ala Asn Arg Thr Ser Leu Phe Tyr 
                85                  90                  95      


Asn Glu Ile Gln Asn Gly Asn Ala Ser Leu Phe Phe Arg Arg Val Ser 
            100                 105                 110         


Leu Leu Asp Glu Gly Ile Tyr Thr Cys Tyr Val Gly Thr Ala Ile Gln 
        115                 120                 125             


Val Ile Thr Asn Lys Val Val Leu Lys Val Gly Val Phe Leu Thr Pro 
    130                 135                 140                 


Val Met Lys Tyr Glu Lys Arg Asn Thr Asn Ser Phe Leu Ile Cys Ser 
145                 150                 155                 160 


Val Leu Ser Val Tyr Pro Arg Pro Ile Ile Thr Trp Lys Met Asp Asn 
                165                 170                 175     


Thr Pro Ile Ser Glu Asn Asn Met Glu Glu Thr Gly Ser Leu Asp Ser 
            180                 185                 190         


Phe Ser Ile Asn Ser Pro Leu Asn Ile Thr Gly Ser Asn Ser Ser Tyr 
        195                 200                 205             


Glu Cys Thr Ile Glu Asn Ser Leu Leu Lys Gln Thr Trp Thr Gly Arg 
    210                 215                 220                 


Trp Thr Met Lys Asp Gly Leu His Lys Met Gln Ser Glu His Val Ser 
225                 230                 235                 240 


Leu Ser Cys Gln Pro Val Asn Asp Tyr Phe Ser Pro Asn Gln Asp Phe 
                245                 250                 255     


Lys Val Thr Trp Ser Arg Met Lys Ser Gly Thr Phe Ser Val Leu Ala 
            260                 265                 270         


Tyr Tyr Leu Ser Ser Ser Gln Asn Thr Ile Ile Asn Glu Ser Arg Phe 
        275                 280                 285             


Ser Trp Asn Lys Glu Leu Ile Asn Gln Ser Asp Phe Ser Met Asn Leu 
    290                 295                 300                 


Met Asp Leu Asn Leu Ser Asp Ser Gly Glu Tyr Leu Cys Asn Ile Ser 
305                 310                 315                 320 


Ser Asp Glu Tyr Thr Leu Leu Thr Ile His Thr Val His Val Glu Pro 
                325                 330                 335     


Ser Gln Glu Thr Ala Ser His Asn Lys Gly Leu Trp Ile Leu Val Pro 
            340                 345                 350         


Ser Ala Ile Leu Ala Ala Phe Leu Leu Ile Trp Ser Val Lys Cys Cys 
        355                 360                 365             


Arg Ala Gln Leu Glu Ala Arg Arg Ser Arg His Pro Ala Asp Gly Ala 
    370                 375                 380                 


Gln Gln Glu Arg Cys Cys Val Pro Pro Gly Glu Arg Cys Pro Ser Ala 
385                 390                 395                 400 


Pro Asp Asn Gly Glu Glu Asn Val Pro Leu Ser Gly Lys Val 
                405                 410                 

<210>  142
<211>  7074
<212>  DNA
<213>  Homo sapiens

<400>  142
catttctact tcatatgatc attttaattg tatttacctc atcttaccaa aaagatcatg     60

gttgaatctt gcctactcac gtttagggcc tttttttggt ggattgcttt aataaagatg    120

gatctgtcag accttggaga agccgcagcc ttcctcagaa gaagtgaagc tgagctgctt    180

ctactacagg ccacagcctt ggatgggaag aagaaatgct ggattcctga tggtgagaat    240

gcttatatcg aggctgaggt aaaagggagt gaagatgatg gaacagtaat tgttgagaca    300

gcagatggag agagtctgag cataaaggag gacaaaatcc agcagatgaa tcctccagag    360

tttgaaatga ttgaagacat ggcaatgctg actcacctca atgaggcatc cgtgctgcat    420

accctgaagc ggcgctatgg ccagtggatg atctatacat attcaggtct cttctgtgtg    480

accataaacc cttacaaatg gcttcccgtg tatcagaaag aagtcatggc cgcctacaaa    540

gggaagaggc gatcagaggc tccccctcac atctttgctg ttgccaataa cgcctttcag    600

gacatgcttc acaatcgaga aaatcagtct atactcttca caggagaatc tggtgctgga    660

aagactgtga acagcaaaca tattatccag tattttgcca ccatagcagc catgattgaa    720

tccaggaaaa agcagggggc gttagaagat caaatcatgc aagcgaatac tatcttggaa    780

gcatttggaa atgctaaaac cctgagaaat gacaactcct ctcgttttgg caaattcatc    840

aggatgcact ttggtgccag aggcatgctg tcatctgtgg acattgatat ctatttgctt    900

gaaaagtcca gggtgatttt ccagcaggct ggagagagga actaccacat attctatcaa    960

attctatctg gacaaaaaga gcttcatgac ctgctcctgg tatctgcaaa tccctcagac   1020

ttccactttt gctcctgtgg agcagttact gtggagagct tggatgatgc tgaagaattg   1080

ctggccacag aacaagccat ggacatcttg ggctttcttc ctgatgagaa gtatggatgc   1140

tataaactca ctggagccat catgcacttt ggaaatatga aatttaaaca gaaacctaga   1200

gaagagcaac tggaagcaga tggcacagaa aatgctgaca aagctgcttt cctcatgggc   1260

attaactcct ctgagttggt aaagtgcttg atccatccta gaatcaaagt tggtaacgaa   1320

tatgttacca gaggtcaaac tatagaacag gtaacctgtg ctgtcggtgc cctgtccaag   1380

tcaatgtatg aaaggatgtt taagtggcta gtggcacgga tcaacagggc cctggatgcc   1440

aagctgtcaa ggcagttctt cattggcatt cttgacatca ctggttttga aatccttgag   1500

tataatagcc ttgagcaact ttgcattaat tttaccaatg aaaaattaca acaattcttc   1560

aattggcaca tgtttgttct ggagcaagag gaatataaga aagaaagcat tgaatgggtg   1620

tctattggct ttggtctgga tttgcaagct tgcatagatc tcattgagaa gccaatgggc   1680

atcctttcca tccttgaaga agagtgtatg tttcctaagg ctacagacct gactttcaag   1740

accaaactct ttgacaacca ttttggaaag tcggttcatc tccagaagcc caagcctgat   1800

aagaagaaat ttgaagctca ttttgaactt gtccattatg caggagtggt accttataat   1860

atcagtggtt ggctggaaaa gaacaaagac ctccttaatg aaacagtggt agctgtattt   1920

cagaagtctt ccaacagact cctggcgagc ctttttgaaa attacatgag tactgacagt   1980

gctataccat ttggggagaa gaaacgaaag aaaggagctt cattccaaac ggttgcatct   2040

ctgcataaag aaaacctgaa taaattgatg actaatctga aatcaacagc acctcatttt   2100

gtgagatgca taaatcccaa tgtgaacaaa ataccaggta tactggaccc ttacttggtt   2160

ctacagcagt tgcgctgtaa tggtgtcttg gaagggacta ggatatgccg tgaaggtttt   2220

ccaaaccgac tgcagtatgc tgattttaaa caaaggtact gcattctgaa tccaaggacc   2280

tttccaaaga gcaagtttgt gagcagcaga aaagcagctg aagaattact tggctccttg   2340

gagatagacc atacccagta ccgatttgga atcactaagg tgttttttaa agctgggttt   2400

ctgggccaac tggaagcaat aagagatgag agactatcta aagtcttcac attgttccaa   2460

gccagagcac agggcaaact gatgcgaatc aaattccaga agattctgga agaaagggat   2520

gcacttattt tgatccaatg gaacataaga gctttcatgg ctgtgaagaa ctggccctgg   2580

atgaggctct tcttcaagat caagcctctt gttaaatctt cagaagtagg agaagaagta   2640

gctggactga aggaagagtg tgcacaatta cagaaagcct tggagaaatc agagtttcag   2700

agggaggaac tgaaagcaaa gcaagtatcc ctcactcagg aaaaaaatga cctgattctt   2760

cagcttcagg ctgagcaaga gacactggca aatgttgaag agcagtgcga gtggctgatt   2820

aaatccaaga tccagctgga ggccagagta aaggagctgt cggagagggt ggaggaagaa   2880

gaggagataa attctgagct gactgccagg gggcggaaac tcgaagatga atgttttgag   2940

ttgaagaaag aaatcgatga cctggaaaca atgttggtga agtcagagaa ggagaagcgt   3000

actacagagc acaaggtcaa gaacttgact gaggaagtag agtttctaaa tgaggatatc   3060

agcaaactta acagagcagc caaggttgtg caggaggccc atcagcagac cctggatgac   3120

ctgcacatgg aggaggagaa gctcagcagc ctgagcaaag caaatctgaa gctggaacag   3180

caagttgatg agcttgaggg tgcccttgag caggagagaa aagcgagaat gaactgtgaa   3240

agggaactgc acaaactgga gggcaattta aagctgaatc gggaaagtat ggagaacctg   3300

gaaagcagcc agcgacacct ggcagaagag ctgaggaaaa aagaattaga attgagtcag   3360

atgaattcaa aagtggagaa tgagaaaggc ctggtagctc agcttcagaa gacggttaaa   3420

gagcttcaga ctcaaataaa ggatttgaaa gagaaactag aagctgaaag gaccactcga   3480

gccaagatgg aaagggagag agctgacctc acccaagacc tggctgactt gaatgagagg   3540

ctggaggagg taggaggatc cagtttggct cagctggaaa taactaagaa acaggaaacc   3600

aaattccaga agctgcaccg agacatggaa gaggccactc tgcactttga gacaacttct   3660

gcatctttga agaagagaca tgcagacagc ctggctgagc tcgagggcca ggtagaaaat   3720

ctacagcagg tcaagcagaa actggaaaaa gacaagagtg acttgcagct agaagtagat   3780

gacctcctga cccgtgttga gcagatgaca agagctaagg caaatgctga gaaactctgt   3840

actctatatg aagagcgctt gcatgaagca actgcaaagc tagataaggt gactcagttg   3900

gcaaatgacc tggcagcaca aaagacaaag ctgtggagtg agagtggcga gttcctacgg   3960

aggcttgaag agaaggaggc tctgataaac caactttcca gggaaaagag caacttcact   4020

cggcagattg aagacctgag agggcagctg gaaaaggaga ccaaatccca gagtgccctg   4080

gcccatgccc tgcagaaggc tcagcgtgac tgtgaccttc tacgagagca gtatgaggaa   4140

gaacaagagg tcaaggctga gctgcaccgg accttatcca aagtcaatgc tgaaatggtg   4200

caatggagaa tgaagtatga aaacaatgtc atccagagaa cagaagactt ggaggatgcc   4260

aagaaggaac tggcaattag attgcaggag gcagccgaag ccatgggggt ggccaatgcc   4320

agaaatgcct ccttggagag agccaggcac cagctgcagc tggagctcgg ggacgccctg   4380

tctgacctcg ggaaggtccg ctctgcagca gccaggctgg accagaagca gctgcagtct   4440

ggcaaggccc ttgccgactg gaagcagaag cacgaggagt cccaggcgtt gctggatgcc   4500

tctcagaagg aagttcaggc tctcagtaca gagctcctca agctcaagaa cacctatgag   4560

gagagcatcg tgggccagga gacactcagg agggagaaca agaacctcca agaagagatt   4620

tctaatctga caaaccaggt tagagaaggg accaagaact taactgaaat ggaaaaggtc   4680

aagaaactaa ttgaagaaga gaagacagaa gtccaggtga cactggaaga aacagaggga   4740

gccctggaac gtaatgaaag caagattctt catttccagc ttgaactctt ggaagctaaa   4800

gcagaacttg aaagaaagct ttcagagaaa gatgaagaaa tagaaaattt taggaggaag   4860

cagcagtgta ccattgactc cctgcagtct agtctggatt ctgaagctaa gagcagaatt   4920

gaggttaccc ggctgaagaa gaagatggaa gaggacctca atgagatgga actccagctt   4980

agctgtgcca accggcaggt gtcagaagca accaaatccc tgggccagct tcagattcaa   5040

atcaaggacc ttcaaatgca gctggatgac agcacacaac tgaacagtga tctgaaggag   5100

caggtggctg tggctgagcg gcgcaactct cttcttcagt ctgaactaga ggatctaagg   5160

tccctgcaag agcagacaga gcgtggccgc aggctgtcag aagaagagct cctggaagca   5220

acagaaagaa tcaatctttt ctatacccag aacacaagcc tcctcagcca gaagaagaaa   5280

ctggaggctg atgttgcccg gatgcagaaa gaagctgaag aggtggtgca ggagtgtcaa   5340

aatgcagaag agaaggccaa gaaggcagcc attgaggcag caaacttgtc agaagaactg   5400

aagaagaagc aagacaccat tgcccacttg gaaaggacaa gagaaaatat ggagcagaca   5460

attacagact tacagaaaag gctggctgaa gctgaacaga tggccctgat ggggagtaga   5520

aagcaaatcc agaaactaga atccagggtt cgtgaactgg aaggtgaact ggagggtgaa   5580

atccgtcgca gtgcagaggc ccagagggga gcccgcagac ttgagcgatg catcaaagag   5640

ctgacctatc aggcagagga agacaagaag aatctgagca ggatgcaaac tcagatggat   5700

aaacttcagc taaaagtgca aaattacaag cagcaagtcg aggtggcgga aacacaagcc   5760

aatcaatacc tttccaagta taagaaacag caacatgagt tgaatgaagt gaaggaaagg   5820

gcagaggtgg cagaatctca agtcaataaa ctcaaaatta aagcaagaga gtttgggaaa   5880

aaggttcaag aagaatagca tcccctgctt tgaaaggaca acagctggag aagtacaagg   5940

aaggtgctgt ttcatggcca aaaacttagg ttgcatggaa acatttttaa aaacatgttt   6000

aaattgcttt tcacaccata taaacaaggc aattagaaaa ataattaaag ggaatatcat   6060

tgcttccaca gttaatgggg attttttgat cctcaaatgc aagtaaacta ccttctaatg   6120

cttcacatga cagattaaat aaatggaaga accttttcaa ttctgatgtt taaaaaatga   6180

ataaatactt gatcctttgt ccatatttcc tcttaatggg taggactcat agaagatgtc   6240

cttagaccag tcacgcttca tggggactag ggcatgttgg tgaatggttt ttactaaagt   6300

taggcaactt tggcttgatt cacccctaaa tctatgaatg tatattgtga gccagcagtg   6360

gtagaatgga agtcataaga tctcctcagc attgtgatat aaatatagct atagttaggc   6420

aatttgaaca tgtaggcaaa actctcctaa tcaacacaca tgtaggctat atgctggtac   6480

atgctttaaa catggaggta accccacacg agacattcag tgacaggtaa tatgctggat   6540

ttgtgcagta ccgatttggc tcagctggag gaacatgtcc cggaattcct ctctctcatg   6600

gttctggatt ggagtaggtc ataaagaaat ttgcattaat ttgatcagca gctattttat   6660

actcataagg tcagtgtaca gacccaagca tggtgacagc ttgaaaatat gactccaggc   6720

caaaaagggg agctagaaga gaccagagac agctccctgg acccagagct cttccagctc   6780

ctgccagcct cctccttcag ctttgcaaag tactggccag gtgtgtgtgc agctccatgg   6840

caaccagcat cagcttttcc tgagatcaca cacagcattg cagtggaggc cgtgagacag   6900

acatgggttc tgtttgttct tatggacttc ccttcatcct tgctgcattc acagtcgacc   6960

tacagtgact tcaggcccag aaccagatgc agagggaaca gcctggccta gacttctcca   7020

ccagcaccca caattgtgta aggctgaagc tctataataa atctttattc tgtc         7074


<210>  143
<211>  1946
<212>  PRT
<213>  Homo sapiens

<400>  143


Met Val Glu Ser Cys Leu Leu Thr Phe Arg Ala Phe Phe Trp Trp Ile 
1               5                   10                  15      


Ala Leu Ile Lys Met Asp Leu Ser Asp Leu Gly Glu Ala Ala Ala Phe 
            20                  25                  30          


Leu Arg Arg Ser Glu Ala Glu Leu Leu Leu Leu Gln Ala Thr Ala Leu 
        35                  40                  45              


Asp Gly Lys Lys Lys Cys Trp Ile Pro Asp Gly Glu Asn Ala Tyr Ile 
    50                  55                  60                  


Glu Ala Glu Val Lys Gly Ser Glu Asp Asp Gly Thr Val Ile Val Glu 
65                  70                  75                  80  


Thr Ala Asp Gly Glu Ser Leu Ser Ile Lys Glu Asp Lys Ile Gln Gln 
                85                  90                  95      


Met Asn Pro Pro Glu Phe Glu Met Ile Glu Asp Met Ala Met Leu Thr 
            100                 105                 110         


His Leu Asn Glu Ala Ser Val Leu His Thr Leu Lys Arg Arg Tyr Gly 
        115                 120                 125             


Gln Trp Met Ile Tyr Thr Tyr Ser Gly Leu Phe Cys Val Thr Ile Asn 
    130                 135                 140                 


Pro Tyr Lys Trp Leu Pro Val Tyr Gln Lys Glu Val Met Ala Ala Tyr 
145                 150                 155                 160 


Lys Gly Lys Arg Arg Ser Glu Ala Pro Pro His Ile Phe Ala Val Ala 
                165                 170                 175     


Asn Asn Ala Phe Gln Asp Met Leu His Asn Arg Glu Asn Gln Ser Ile 
            180                 185                 190         


Leu Phe Thr Gly Glu Ser Gly Ala Gly Lys Thr Val Asn Ser Lys His 
        195                 200                 205             


Ile Ile Gln Tyr Phe Ala Thr Ile Ala Ala Met Ile Glu Ser Arg Lys 
    210                 215                 220                 


Lys Gln Gly Ala Leu Glu Asp Gln Ile Met Gln Ala Asn Thr Ile Leu 
225                 230                 235                 240 


Glu Ala Phe Gly Asn Ala Lys Thr Leu Arg Asn Asp Asn Ser Ser Arg 
                245                 250                 255     


Phe Gly Lys Phe Ile Arg Met His Phe Gly Ala Arg Gly Met Leu Ser 
            260                 265                 270         


Ser Val Asp Ile Asp Ile Tyr Leu Leu Glu Lys Ser Arg Val Ile Phe 
        275                 280                 285             


Gln Gln Ala Gly Glu Arg Asn Tyr His Ile Phe Tyr Gln Ile Leu Ser 
    290                 295                 300                 


Gly Gln Lys Glu Leu His Asp Leu Leu Leu Val Ser Ala Asn Pro Ser 
305                 310                 315                 320 


Asp Phe His Phe Cys Ser Cys Gly Ala Val Thr Val Glu Ser Leu Asp 
                325                 330                 335     


Asp Ala Glu Glu Leu Leu Ala Thr Glu Gln Ala Met Asp Ile Leu Gly 
            340                 345                 350         


Phe Leu Pro Asp Glu Lys Tyr Gly Cys Tyr Lys Leu Thr Gly Ala Ile 
        355                 360                 365             


Met His Phe Gly Asn Met Lys Phe Lys Gln Lys Pro Arg Glu Glu Gln 
    370                 375                 380                 


Leu Glu Ala Asp Gly Thr Glu Asn Ala Asp Lys Ala Ala Phe Leu Met 
385                 390                 395                 400 


Gly Ile Asn Ser Ser Glu Leu Val Lys Cys Leu Ile His Pro Arg Ile 
                405                 410                 415     


Lys Val Gly Asn Glu Tyr Val Thr Arg Gly Gln Thr Ile Glu Gln Val 
            420                 425                 430         


Thr Cys Ala Val Gly Ala Leu Ser Lys Ser Met Tyr Glu Arg Met Phe 
        435                 440                 445             


Lys Trp Leu Val Ala Arg Ile Asn Arg Ala Leu Asp Ala Lys Leu Ser 
    450                 455                 460                 


Arg Gln Phe Phe Ile Gly Ile Leu Asp Ile Thr Gly Phe Glu Ile Leu 
465                 470                 475                 480 


Glu Tyr Asn Ser Leu Glu Gln Leu Cys Ile Asn Phe Thr Asn Glu Lys 
                485                 490                 495     


Leu Gln Gln Phe Phe Asn Trp His Met Phe Val Leu Glu Gln Glu Glu 
            500                 505                 510         


Tyr Lys Lys Glu Ser Ile Glu Trp Val Ser Ile Gly Phe Gly Leu Asp 
        515                 520                 525             


Leu Gln Ala Cys Ile Asp Leu Ile Glu Lys Pro Met Gly Ile Leu Ser 
    530                 535                 540                 


Ile Leu Glu Glu Glu Cys Met Phe Pro Lys Ala Thr Asp Leu Thr Phe 
545                 550                 555                 560 


Lys Thr Lys Leu Phe Asp Asn His Phe Gly Lys Ser Val His Leu Gln 
                565                 570                 575     


Lys Pro Lys Pro Asp Lys Lys Lys Phe Glu Ala His Phe Glu Leu Val 
            580                 585                 590         


His Tyr Ala Gly Val Val Pro Tyr Asn Ile Ser Gly Trp Leu Glu Lys 
        595                 600                 605             


Asn Lys Asp Leu Leu Asn Glu Thr Val Val Ala Val Phe Gln Lys Ser 
    610                 615                 620                 


Ser Asn Arg Leu Leu Ala Ser Leu Phe Glu Asn Tyr Met Ser Thr Asp 
625                 630                 635                 640 


Ser Ala Ile Pro Phe Gly Glu Lys Lys Arg Lys Lys Gly Ala Ser Phe 
                645                 650                 655     


Gln Thr Val Ala Ser Leu His Lys Glu Asn Leu Asn Lys Leu Met Thr 
            660                 665                 670         


Asn Leu Lys Ser Thr Ala Pro His Phe Val Arg Cys Ile Asn Pro Asn 
        675                 680                 685             


Val Asn Lys Ile Pro Gly Ile Leu Asp Pro Tyr Leu Val Leu Gln Gln 
    690                 695                 700                 


Leu Arg Cys Asn Gly Val Leu Glu Gly Thr Arg Ile Cys Arg Glu Gly 
705                 710                 715                 720 


Phe Pro Asn Arg Leu Gln Tyr Ala Asp Phe Lys Gln Arg Tyr Cys Ile 
                725                 730                 735     


Leu Asn Pro Arg Thr Phe Pro Lys Ser Lys Phe Val Ser Ser Arg Lys 
            740                 745                 750         


Ala Ala Glu Glu Leu Leu Gly Ser Leu Glu Ile Asp His Thr Gln Tyr 
        755                 760                 765             


Arg Phe Gly Ile Thr Lys Val Phe Phe Lys Ala Gly Phe Leu Gly Gln 
    770                 775                 780                 


Leu Glu Ala Ile Arg Asp Glu Arg Leu Ser Lys Val Phe Thr Leu Phe 
785                 790                 795                 800 


Gln Ala Arg Ala Gln Gly Lys Leu Met Arg Ile Lys Phe Gln Lys Ile 
                805                 810                 815     


Leu Glu Glu Arg Asp Ala Leu Ile Leu Ile Gln Trp Asn Ile Arg Ala 
            820                 825                 830         


Phe Met Ala Val Lys Asn Trp Pro Trp Met Arg Leu Phe Phe Lys Ile 
        835                 840                 845             


Lys Pro Leu Val Lys Ser Ser Glu Val Gly Glu Glu Val Ala Gly Leu 
    850                 855                 860                 


Lys Glu Glu Cys Ala Gln Leu Gln Lys Ala Leu Glu Lys Ser Glu Phe 
865                 870                 875                 880 


Gln Arg Glu Glu Leu Lys Ala Lys Gln Val Ser Leu Thr Gln Glu Lys 
                885                 890                 895     


Asn Asp Leu Ile Leu Gln Leu Gln Ala Glu Gln Glu Thr Leu Ala Asn 
            900                 905                 910         


Val Glu Glu Gln Cys Glu Trp Leu Ile Lys Ser Lys Ile Gln Leu Glu 
        915                 920                 925             


Ala Arg Val Lys Glu Leu Ser Glu Arg Val Glu Glu Glu Glu Glu Ile 
    930                 935                 940                 


Asn Ser Glu Leu Thr Ala Arg Gly Arg Lys Leu Glu Asp Glu Cys Phe 
945                 950                 955                 960 


Glu Leu Lys Lys Glu Ile Asp Asp Leu Glu Thr Met Leu Val Lys Ser 
                965                 970                 975     


Glu Lys Glu Lys Arg Thr Thr Glu His Lys Val Lys Asn Leu Thr Glu 
            980                 985                 990         


Glu Val Glu Phe Leu Asn Glu Asp  Ile Ser Lys Leu Asn  Arg Ala Ala 
        995                 1000                 1005             


Lys Val  Val Gln Glu Ala His  Gln Gln Thr Leu Asp  Asp Leu His 
    1010                 1015                 1020             


Met Glu  Glu Glu Lys Leu Ser  Ser Leu Ser Lys Ala  Asn Leu Lys 
    1025                 1030                 1035             


Leu Glu  Gln Gln Val Asp Glu  Leu Glu Gly Ala Leu  Glu Gln Glu 
    1040                 1045                 1050             


Arg Lys  Ala Arg Met Asn Cys  Glu Arg Glu Leu His  Lys Leu Glu 
    1055                 1060                 1065             


Gly Asn  Leu Lys Leu Asn Arg  Glu Ser Met Glu Asn  Leu Glu Ser 
    1070                 1075                 1080             


Ser Gln  Arg His Leu Ala Glu  Glu Leu Arg Lys Lys  Glu Leu Glu 
    1085                 1090                 1095             


Leu Ser  Gln Met Asn Ser Lys  Val Glu Asn Glu Lys  Gly Leu Val 
    1100                 1105                 1110             


Ala Gln  Leu Gln Lys Thr Val  Lys Glu Leu Gln Thr  Gln Ile Lys 
    1115                 1120                 1125             


Asp Leu  Lys Glu Lys Leu Glu  Ala Glu Arg Thr Thr  Arg Ala Lys 
    1130                 1135                 1140             


Met Glu  Arg Glu Arg Ala Asp  Leu Thr Gln Asp Leu  Ala Asp Leu 
    1145                 1150                 1155             


Asn Glu  Arg Leu Glu Glu Val  Gly Gly Ser Ser Leu  Ala Gln Leu 
    1160                 1165                 1170             


Glu Ile  Thr Lys Lys Gln Glu  Thr Lys Phe Gln Lys  Leu His Arg 
    1175                 1180                 1185             


Asp Met  Glu Glu Ala Thr Leu  His Phe Glu Thr Thr  Ser Ala Ser 
    1190                 1195                 1200             


Leu Lys  Lys Arg His Ala Asp  Ser Leu Ala Glu Leu  Glu Gly Gln 
    1205                 1210                 1215             


Val Glu  Asn Leu Gln Gln Val  Lys Gln Lys Leu Glu  Lys Asp Lys 
    1220                 1225                 1230             


Ser Asp  Leu Gln Leu Glu Val  Asp Asp Leu Leu Thr  Arg Val Glu 
    1235                 1240                 1245             


Gln Met  Thr Arg Ala Lys Ala  Asn Ala Glu Lys Leu  Cys Thr Leu 
    1250                 1255                 1260             


Tyr Glu  Glu Arg Leu His Glu  Ala Thr Ala Lys Leu  Asp Lys Val 
    1265                 1270                 1275             


Thr Gln  Leu Ala Asn Asp Leu  Ala Ala Gln Lys Thr  Lys Leu Trp 
    1280                 1285                 1290             


Ser Glu  Ser Gly Glu Phe Leu  Arg Arg Leu Glu Glu  Lys Glu Ala 
    1295                 1300                 1305             


Leu Ile  Asn Gln Leu Ser Arg  Glu Lys Ser Asn Phe  Thr Arg Gln 
    1310                 1315                 1320             


Ile Glu  Asp Leu Arg Gly Gln  Leu Glu Lys Glu Thr  Lys Ser Gln 
    1325                 1330                 1335             


Ser Ala  Leu Ala His Ala Leu  Gln Lys Ala Gln Arg  Asp Cys Asp 
    1340                 1345                 1350             


Leu Leu  Arg Glu Gln Tyr Glu  Glu Glu Gln Glu Val  Lys Ala Glu 
    1355                 1360                 1365             


Leu His  Arg Thr Leu Ser Lys  Val Asn Ala Glu Met  Val Gln Trp 
    1370                 1375                 1380             


Arg Met  Lys Tyr Glu Asn Asn  Val Ile Gln Arg Thr  Glu Asp Leu 
    1385                 1390                 1395             


Glu Asp  Ala Lys Lys Glu Leu  Ala Ile Arg Leu Gln  Glu Ala Ala 
    1400                 1405                 1410             


Glu Ala  Met Gly Val Ala Asn  Ala Arg Asn Ala Ser  Leu Glu Arg 
    1415                 1420                 1425             


Ala Arg  His Gln Leu Gln Leu  Glu Leu Gly Asp Ala  Leu Ser Asp 
    1430                 1435                 1440             


Leu Gly  Lys Val Arg Ser Ala  Ala Ala Arg Leu Asp  Gln Lys Gln 
    1445                 1450                 1455             


Leu Gln  Ser Gly Lys Ala Leu  Ala Asp Trp Lys Gln  Lys His Glu 
    1460                 1465                 1470             


Glu Ser  Gln Ala Leu Leu Asp  Ala Ser Gln Lys Glu  Val Gln Ala 
    1475                 1480                 1485             


Leu Ser  Thr Glu Leu Leu Lys  Leu Lys Asn Thr Tyr  Glu Glu Ser 
    1490                 1495                 1500             


Ile Val  Gly Gln Glu Thr Leu  Arg Arg Glu Asn Lys  Asn Leu Gln 
    1505                 1510                 1515             


Glu Glu  Ile Ser Asn Leu Thr  Asn Gln Val Arg Glu  Gly Thr Lys 
    1520                 1525                 1530             


Asn Leu  Thr Glu Met Glu Lys  Val Lys Lys Leu Ile  Glu Glu Glu 
    1535                 1540                 1545             


Lys Thr  Glu Val Gln Val Thr  Leu Glu Glu Thr Glu  Gly Ala Leu 
    1550                 1555                 1560             


Glu Arg  Asn Glu Ser Lys Ile  Leu His Phe Gln Leu  Glu Leu Leu 
    1565                 1570                 1575             


Glu Ala  Lys Ala Glu Leu Glu  Arg Lys Leu Ser Glu  Lys Asp Glu 
    1580                 1585                 1590             


Glu Ile  Glu Asn Phe Arg Arg  Lys Gln Gln Cys Thr  Ile Asp Ser 
    1595                 1600                 1605             


Leu Gln  Ser Ser Leu Asp Ser  Glu Ala Lys Ser Arg  Ile Glu Val 
    1610                 1615                 1620             


Thr Arg  Leu Lys Lys Lys Met  Glu Glu Asp Leu Asn  Glu Met Glu 
    1625                 1630                 1635             


Leu Gln  Leu Ser Cys Ala Asn  Arg Gln Val Ser Glu  Ala Thr Lys 
    1640                 1645                 1650             


Ser Leu  Gly Gln Leu Gln Ile  Gln Ile Lys Asp Leu  Gln Met Gln 
    1655                 1660                 1665             


Leu Asp  Asp Ser Thr Gln Leu  Asn Ser Asp Leu Lys  Glu Gln Val 
    1670                 1675                 1680             


Ala Val  Ala Glu Arg Arg Asn  Ser Leu Leu Gln Ser  Glu Leu Glu 
    1685                 1690                 1695             


Asp Leu  Arg Ser Leu Gln Glu  Gln Thr Glu Arg Gly  Arg Arg Leu 
    1700                 1705                 1710             


Ser Glu  Glu Glu Leu Leu Glu  Ala Thr Glu Arg Ile  Asn Leu Phe 
    1715                 1720                 1725             


Tyr Thr  Gln Asn Thr Ser Leu  Leu Ser Gln Lys Lys  Lys Leu Glu 
    1730                 1735                 1740             


Ala Asp  Val Ala Arg Met Gln  Lys Glu Ala Glu Glu  Val Val Gln 
    1745                 1750                 1755             


Glu Cys  Gln Asn Ala Glu Glu  Lys Ala Lys Lys Ala  Ala Ile Glu 
    1760                 1765                 1770             


Ala Ala  Asn Leu Ser Glu Glu  Leu Lys Lys Lys Gln  Asp Thr Ile 
    1775                 1780                 1785             


Ala His  Leu Glu Arg Thr Arg  Glu Asn Met Glu Gln  Thr Ile Thr 
    1790                 1795                 1800             


Asp Leu  Gln Lys Arg Leu Ala  Glu Ala Glu Gln Met  Ala Leu Met 
    1805                 1810                 1815             


Gly Ser  Arg Lys Gln Ile Gln  Lys Leu Glu Ser Arg  Val Arg Glu 
    1820                 1825                 1830             


Leu Glu  Gly Glu Leu Glu Gly  Glu Ile Arg Arg Ser  Ala Glu Ala 
    1835                 1840                 1845             


Gln Arg  Gly Ala Arg Arg Leu  Glu Arg Cys Ile Lys  Glu Leu Thr 
    1850                 1855                 1860             


Tyr Gln  Ala Glu Glu Asp Lys  Lys Asn Leu Ser Arg  Met Gln Thr 
    1865                 1870                 1875             


Gln Met  Asp Lys Leu Gln Leu  Lys Val Gln Asn Tyr  Lys Gln Gln 
    1880                 1885                 1890             


Val Glu  Val Ala Glu Thr Gln  Ala Asn Gln Tyr Leu  Ser Lys Tyr 
    1895                 1900                 1905             


Lys Lys  Gln Gln His Glu Leu  Asn Glu Val Lys Glu  Arg Ala Glu 
    1910                 1915                 1920             


Val Ala  Glu Ser Gln Val Asn  Lys Leu Lys Ile Lys  Ala Arg Glu 
    1925                 1930                 1935             


Phe Gly  Lys Lys Val Gln Glu  Glu 
    1940                 1945     

<210>  144
<211>  5021
<212>  DNA
<213>  Homo sapiens

<400>  144
aataaagaaa taaaacaggt gtctgaggag aggttctatt agagagggga gaatagagag     60

taattatcgt tcagacaggc aagagttctc tgcaggtagc agcctgggaa agcgaactcg    120

cgcaccctct tgggggacgg gctcttttgc tttctatttc ttctcctgca gccagggtgc    180

acacgtattt gaaacagacc gaatttcctc ctcgatgtgg cgtcaggttg acttttcgag    240

actagcgggt atttcttttt aatgactcca atgccttttt attattgctg ttattgaggt    300

tgagggagaa gagatcggtc taaattctgg ctgggtaagt ggggggattc tcggcgatga    360

gaaacggggg acttagaagc cggaggaaaa tcagcagccc cacatctcca cttctccagt    420

ccgccctact ctccacccgt gacctccagt ggagacccca ggcggcagca tcagtatttg    480

atcggccctt cgtcagcacg ctgccagccc tggccggctg ggttcgccag gcatcacccg    540

ctcggctctg aagcggacgc ctggccctgc accgggcttt ggaaggaccc tctctgcgct    600

cgccccctcc ccagggtggc tccgctttcg agcccgggcg cggtgcccac catgcgcggc    660

tgcctgcggc tcgcgctgct ctgcgcgctg ccctggctcc tgctggcggc gtcgcccggg    720

cacccggcga aatcccccag gcagcccccg gcaccgcgcc gcgacccctt cgacgctgcc    780

aggggcgccg atttcgatca tgtctacagc ggggtggtga acctcagcac cgagaacatc    840

tactctttca actacaccag ccagcccgac caggtgacag ccgtgagggt gtatgtgaac    900

agttcctctg agaatctcaa ctacccggtc cttgttgtgg ttcgccagca gaaagaggtg    960

ctgtcctggc aggttcctct gctcttccaa ggactatacc agaggagcta caactatcaa   1020

gaagtgagcc gcaccttatg tccctcagaa gcaaccaatg agacgggacc cttgcagcaa   1080

ctgatatttg tagatgtcgc atccatggca cccctgggtg ctcagtacaa actgctagtt   1140

accaagctga agcacttcca gctccggaca aatgttgcct ttcactttac tgccagcccc   1200

tctcaacctc agtattttct atacaagttt cccaaagacg tggactcagt tatcattaaa   1260

gtggtgtctg aaatggctta tccatgttct gttgtctcag tccagaatat catgtgcccg   1320

gtgtatgatc tcgaccacaa tgtggaattt aatggtgtct atcagtccat gaccaagaaa   1380

gctgccatca cgctacagaa gaaggatttt ccaggcgagc agttcttcgt ggtatttgtg   1440

ataaagcctg aagattatgc ctgtggagga tctttcttca tccaggaaaa ggaaaaccag   1500

acctggaatc tacagcgaaa aaagaacctt gaagtgacca ttgtcccttc cattaaagaa   1560

tctgtttatg tgaaatccag tcttttcagt gtcttcatct tcctgtcctt ctacttggga   1620

tgccttcttg ttgggtttgt tcattatctg aggtttcaga gaaaatccat tgatggaagc   1680

tttgggtcca atgatggctc tggaaatatg gtggcatctc atcccattgc tgccagcaca   1740

cccgaaggga gcaattatgg gacaatagat gagtcaagct ccagtcctgg aaggcagatg   1800

tcctcctccg atggtgggcc accgggccag tcagacacag acagctccgt ggaggagagc   1860

gacttcgaca ccatgccaga cattgagagt gataaaaaca tcatccggac caagatgttc   1920

ctttacctgt cagatttgtc caggaaggac cggagaattg tcagcaaaaa atataaaatt   1980

tatttttgga acatcatcac cattgctgtg ttttacgcgc tgcccgtgat ccagctggtc   2040

attacctatc agacagtggt aaatgtcact ggcaaccagg acatctgtta ctacaacttc   2100

ctctgtgctc accccttggg cgtcctgagt gccttcaaca acattctcag caatctgggc   2160

cacgtgcttc tgggcttcct cttcctgctg atagtcttgc gccgcgacat cctccatcgg   2220

agagccctgg aagccaagga catctttgct gtggagtacg ggattcccaa acactttggt   2280

ctcttctacg ctatgggcat tgcattgatg atggaagggg tgctcagtgc ttgctaccat   2340

gtctgcccta attattccaa cttccaattc gacacctcct tcatgtacat gatcgctggc   2400

ctgtgcatgc tgaagctcta tcagacccgc cacccagaca tcaatgccag cgcctactct   2460

gcctatgcct cctttgctgt ggtcatcatg gtcaccgtcc ttggagtggt gtttggaaaa   2520

aatgacgtat ggttctgggt catcttctct gcaatccacg ttctggcctc gctagccctc   2580

agcacccaga tatattatat gggtcgtttc aagatagatt tgggaatttt ccggcgggct   2640

gccatggtgt tctacacaga ctgtatccag cagtgtagcc gacctctata tatggataga   2700

atggtgttgc tggttgtggg gaatctggtt aactggtcct tcgccctctt tggattgata   2760

taccgcccca gggactttgc ttcctacatg ctgggcatct tcatctgtaa ccttttgctg   2820

tacctggcct tttacatcat catgaagctc cgcagctctg aaaaggtcct cccagtcccg   2880

ctcttctgca tcgtggccac cgctgtgatg tgggctgccg ccctatattt tttcttccag   2940

aatctcagca gctgggaggg aactccggcc gaatcccggg agaagaaccg cgagtgcatt   3000

ctgctggatt tcttcgatga ccatgacatc tggcacttcc tctctgctac tgctctgttt   3060

ttctcattct tggttttgtt aactttggat gatgaccttg atgtggttcg gagagaccag   3120

atccctgtct tctgaacctc caacattaag agaggggagg gagcgatcaa tcttggtgct   3180

gtttcacaaa aattacagtg accacagcaa agtaaccact gccagatgct ccactcaccc   3240

tctgtagagc caactctgca ttcacacagg aaggagaggg gctgcgggag atttaaacct   3300

gcaagaaagg aggcagaagg ggagccatgt tttgaggaca gacgcaaacc tgaggagctg   3360

agaaacactt gctccttcca tctgcagctt tgggagtgca acagggatag gcactgcatc   3420

caagtcaact caccatcttg gggtccctcc caccctcacg gagacttgcc agcaatggca   3480

gaatgctgct gcacacttcc ctccagttgt caccctgccc agaaaggcca gcagcttgga   3540

cttcctgccc agaaactgtg ttggccccct tcacacctct gcaacacctg ctgctccagc   3600

aagaggatgt gattctttag aatatggcgg ggaggtgacc ccaggccctg ccctactggg   3660

atagatgttt taatggcacc agctagtcac ctcccagaag aaactctgta tatttccccc   3720

aggtttctga tgccatcaga agggctcagg agtggggttt gtcacacatt cctcttaaca   3780

agtaactgtc actgggaccg agtcctgggt gcttacatat tccttcgtgt cttcatctca   3840

ctgacctgtg tggacctcat cactctgact ctgccttctt ggaaaggccc tgtcactcca   3900

cagatgtctg gccagcttca aggcagaagg aaaaacagga aaagctcttt taacagcagc   3960

aggaacaaga gaaatgacta accatactaa aagactggta acagcagcag cagccagaca   4020

ggcctcacct taaggacttg ggctgccaga gcaaattcag cagagcttat ttggcctccc   4080

attcacacag ctcagttctg tgcccacatc acctttgggg aagaaatcag cattctaatc   4140

agggacacta cttcaggagt cctccacagc gagtccgtca tctgtcactt tatgtagatc   4200

agggttctag acttcttccc tgaggttctc agaagcagct ctcaggatga acgtattgtc   4260

ctcttcccct cttcttgcaa agtgcacagc taatctaatg ttgtctctcg gttgcacctg   4320

acattctctc cccagtaagg tgttggcaag ctcagcatct gggttccact ctcacactgt   4380

ctggcagctc tgtgtctgag aagttctaca ttgaccaggc ccccttgttg cctggagtat   4440

gacgtaatca gaaaatagac gtataaatgt gcacatgcgt atgtatttgc ttgtgaaatt   4500

aaagtcacct cttgcctctg ctttcctgat cattcgttag agaaatggat caggcatttt   4560

tttaaattat tattctttct ctaaactatt tgcattgtgt tcaaaaaccc attttagaag   4620

tttgaacagc aagcttttcc tgattttaaa aacacaaagt tgctttcaat gaaatatttt   4680

gtgatttttt taaagtcccc aaatgtgtac ttagccttct gttattcctt attctttaag   4740

cagtgttggc ttccattgac catatgaagg ccaccaatta aatggttgtg ttaatccaac   4800

atgtaaaaaa ctttttggca gggcacagtg gctcacgcct gtaatcccaa cactttggga   4860

ggctgaggca ggaggatcac ttgagcccag gagattgacg ccgcagtgaa ctatgattgt   4920

gcccctgcac tccagcctgg atgacagagt gagaccccat ctcttaaaaa ataaaaaaaa   4980

ataaaaattt gaacctgttt caaaaaaaaa aaaaaaaaaa a                       5021


<210>  145
<211>  827
<212>  PRT
<213>  Homo sapiens

<400>  145


Met Arg Gly Cys Leu Arg Leu Ala Leu Leu Cys Ala Leu Pro Trp Leu 
1               5                   10                  15      


Leu Leu Ala Ala Ser Pro Gly His Pro Ala Lys Ser Pro Arg Gln Pro 
            20                  25                  30          


Pro Ala Pro Arg Arg Asp Pro Phe Asp Ala Ala Arg Gly Ala Asp Phe 
        35                  40                  45              


Asp His Val Tyr Ser Gly Val Val Asn Leu Ser Thr Glu Asn Ile Tyr 
    50                  55                  60                  


Ser Phe Asn Tyr Thr Ser Gln Pro Asp Gln Val Thr Ala Val Arg Val 
65                  70                  75                  80  


Tyr Val Asn Ser Ser Ser Glu Asn Leu Asn Tyr Pro Val Leu Val Val 
                85                  90                  95      


Val Arg Gln Gln Lys Glu Val Leu Ser Trp Gln Val Pro Leu Leu Phe 
            100                 105                 110         


Gln Gly Leu Tyr Gln Arg Ser Tyr Asn Tyr Gln Glu Val Ser Arg Thr 
        115                 120                 125             


Leu Cys Pro Ser Glu Ala Thr Asn Glu Thr Gly Pro Leu Gln Gln Leu 
    130                 135                 140                 


Ile Phe Val Asp Val Ala Ser Met Ala Pro Leu Gly Ala Gln Tyr Lys 
145                 150                 155                 160 


Leu Leu Val Thr Lys Leu Lys His Phe Gln Leu Arg Thr Asn Val Ala 
                165                 170                 175     


Phe His Phe Thr Ala Ser Pro Ser Gln Pro Gln Tyr Phe Leu Tyr Lys 
            180                 185                 190         


Phe Pro Lys Asp Val Asp Ser Val Ile Ile Lys Val Val Ser Glu Met 
        195                 200                 205             


Ala Tyr Pro Cys Ser Val Val Ser Val Gln Asn Ile Met Cys Pro Val 
    210                 215                 220                 


Tyr Asp Leu Asp His Asn Val Glu Phe Asn Gly Val Tyr Gln Ser Met 
225                 230                 235                 240 


Thr Lys Lys Ala Ala Ile Thr Leu Gln Lys Lys Asp Phe Pro Gly Glu 
                245                 250                 255     


Gln Phe Phe Val Val Phe Val Ile Lys Pro Glu Asp Tyr Ala Cys Gly 
            260                 265                 270         


Gly Ser Phe Phe Ile Gln Glu Lys Glu Asn Gln Thr Trp Asn Leu Gln 
        275                 280                 285             


Arg Lys Lys Asn Leu Glu Val Thr Ile Val Pro Ser Ile Lys Glu Ser 
    290                 295                 300                 


Val Tyr Val Lys Ser Ser Leu Phe Ser Val Phe Ile Phe Leu Ser Phe 
305                 310                 315                 320 


Tyr Leu Gly Cys Leu Leu Val Gly Phe Val His Tyr Leu Arg Phe Gln 
                325                 330                 335     


Arg Lys Ser Ile Asp Gly Ser Phe Gly Ser Asn Asp Gly Ser Gly Asn 
            340                 345                 350         


Met Val Ala Ser His Pro Ile Ala Ala Ser Thr Pro Glu Gly Ser Asn 
        355                 360                 365             


Tyr Gly Thr Ile Asp Glu Ser Ser Ser Ser Pro Gly Arg Gln Met Ser 
    370                 375                 380                 


Ser Ser Asp Gly Gly Pro Pro Gly Gln Ser Asp Thr Asp Ser Ser Val 
385                 390                 395                 400 


Glu Glu Ser Asp Phe Asp Thr Met Pro Asp Ile Glu Ser Asp Lys Asn 
                405                 410                 415     


Ile Ile Arg Thr Lys Met Phe Leu Tyr Leu Ser Asp Leu Ser Arg Lys 
            420                 425                 430         


Asp Arg Arg Ile Val Ser Lys Lys Tyr Lys Ile Tyr Phe Trp Asn Ile 
        435                 440                 445             


Ile Thr Ile Ala Val Phe Tyr Ala Leu Pro Val Ile Gln Leu Val Ile 
    450                 455                 460                 


Thr Tyr Gln Thr Val Val Asn Val Thr Gly Asn Gln Asp Ile Cys Tyr 
465                 470                 475                 480 


Tyr Asn Phe Leu Cys Ala His Pro Leu Gly Val Leu Ser Ala Phe Asn 
                485                 490                 495     


Asn Ile Leu Ser Asn Leu Gly His Val Leu Leu Gly Phe Leu Phe Leu 
            500                 505                 510         


Leu Ile Val Leu Arg Arg Asp Ile Leu His Arg Arg Ala Leu Glu Ala 
        515                 520                 525             


Lys Asp Ile Phe Ala Val Glu Tyr Gly Ile Pro Lys His Phe Gly Leu 
    530                 535                 540                 


Phe Tyr Ala Met Gly Ile Ala Leu Met Met Glu Gly Val Leu Ser Ala 
545                 550                 555                 560 


Cys Tyr His Val Cys Pro Asn Tyr Ser Asn Phe Gln Phe Asp Thr Ser 
                565                 570                 575     


Phe Met Tyr Met Ile Ala Gly Leu Cys Met Leu Lys Leu Tyr Gln Thr 
            580                 585                 590         


Arg His Pro Asp Ile Asn Ala Ser Ala Tyr Ser Ala Tyr Ala Ser Phe 
        595                 600                 605             


Ala Val Val Ile Met Val Thr Val Leu Gly Val Val Phe Gly Lys Asn 
    610                 615                 620                 


Asp Val Trp Phe Trp Val Ile Phe Ser Ala Ile His Val Leu Ala Ser 
625                 630                 635                 640 


Leu Ala Leu Ser Thr Gln Ile Tyr Tyr Met Gly Arg Phe Lys Ile Asp 
                645                 650                 655     


Leu Gly Ile Phe Arg Arg Ala Ala Met Val Phe Tyr Thr Asp Cys Ile 
            660                 665                 670         


Gln Gln Cys Ser Arg Pro Leu Tyr Met Asp Arg Met Val Leu Leu Val 
        675                 680                 685             


Val Gly Asn Leu Val Asn Trp Ser Phe Ala Leu Phe Gly Leu Ile Tyr 
    690                 695                 700                 


Arg Pro Arg Asp Phe Ala Ser Tyr Met Leu Gly Ile Phe Ile Cys Asn 
705                 710                 715                 720 


Leu Leu Leu Tyr Leu Ala Phe Tyr Ile Ile Met Lys Leu Arg Ser Ser 
                725                 730                 735     


Glu Lys Val Leu Pro Val Pro Leu Phe Cys Ile Val Ala Thr Ala Val 
            740                 745                 750         


Met Trp Ala Ala Ala Leu Tyr Phe Phe Phe Gln Asn Leu Ser Ser Trp 
        755                 760                 765             


Glu Gly Thr Pro Ala Glu Ser Arg Glu Lys Asn Arg Glu Cys Ile Leu 
    770                 775                 780                 


Leu Asp Phe Phe Asp Asp His Asp Ile Trp His Phe Leu Ser Ala Thr 
785                 790                 795                 800 


Ala Leu Phe Phe Ser Phe Leu Val Leu Leu Thr Leu Asp Asp Asp Leu 
                805                 810                 815     


Asp Val Val Arg Arg Asp Gln Ile Pro Val Phe 
            820                 825         

<210>  146
<211>  2567
<212>  DNA
<213>  Homo sapiens

<400>  146
ggcggcgcag gcgcactggg ttcgccgcgc cgaactgcag ccatggagca ggcacctccg     60

gaccccgagc ggcagctcca gccggcgccc ttggagccgc tgggctcccc agacgctggg    120

ctgggggctg cggtcggcaa ggaagcggag ggggccggag aagagagctc tggggtcgac    180

acgatgacac acaataattt ttggttgaag aagatagaaa tcagtgtttc agaagcagaa    240

aaacgaactg gaagaaatgc catgaacatg caagaaacat atactgctta cctcattgaa    300

acaaggtcag ttgaacatac cgatggtcag agtgtcctaa cagactcact atggcggcga    360

tatagtgaat ttgagttgtt gagaagctac cttttagttt actatccaca tattgttgtg    420

ccacctctgc cagaaaaacg ggcagaattt gtttggcata aactctctgc tgacaacatg    480

gatccagatt ttgtggagag gcgacggatt ggtttagaaa actttctctt gaggattgct    540

tcacatccca tcctttgtag agacaaaatc ttctatctgt ttttaacaca ggaaggtaac    600

tggaaggaga ctgtgaatga aactgggttt cagctgaagg cagactccag gttaaaagcg    660

cttaatgcaa cattcagagt gaaaaaccca gacaagagat ttactgacct taagcactat    720

agtgatgaac tgcagtctgt catctcacat cttcttcgag tcagagctag agtagcagat    780

cgactctatg gtgtatataa agtacatggg aattatggtc gagttttcag tgaatggagt    840

gccatagaaa aagaaatggg tgatggactg cagagtgctg gtcatcatat ggatgtgtat    900

gcatcttcta ttgatgatat tttggaagat gaagaacatt atgcagatca gttaaaagag    960

tatctttttt atgcagaagc attgcgggct gtgtgcagga aacatgaact tatgcagtat   1020

gacttggaga tggctgctca ggacttagca tccaagaagc agcagtgtga ggaactggta   1080

actgggactg tgagaacatt ctctttgaag ggaatgacta ccaagctctt tggtcaagaa   1140

actccagagc agagagaagc cagaataaag gtgctagaag aacaaataaa tgaaggagaa   1200

caacagctaa agtctaaaaa tctggaaggc agagaatttg tgaaaaacgc atgggctgat   1260

attgaacgct tcaaagaaca aaagaaccga gacttaaagg aggccctcat aagctatgca   1320

gtcatgcaga tcagtatgtg caaaaaggga attcaagttt ggaccaatgc taaggaatgc   1380

tttagcaaga tgtaatcctg tgaattgaat ttctcttcaa tcaaagtgcc ccaaaacaga   1440

agcacaagta aataaaagaa atttaagtca ctacctagta tacataaaca tatacaataa   1500

gttaaataaa ttcagctttc tttaacttaa ttgtggtcgt gttaatgtag cacaaaaaat   1560

atattttaat gaagattaaa tattataatt tgaggttttg gggactggtg ctgattccaa   1620

aaagttaatt taataatata taccaacaga ttgtttgtca cgcttctgaa ccaatgactg   1680

aatgtcaaga tgttcgttaa tttctagatg tttgtttcaa gaccagctgt ttcagatcta   1740

ttaatgtagg gaatttttcc ctaagattga attcctatat ttacttggta agatccacta   1800

atctgttata gggagttgtt ttctcttgcc ttatagttga gctatttggt ttgacaaagc   1860

tcagcagaaa cttgatgtga aaaatctacg attttcttct acattcattg atgccccttg   1920

taatgtttgc atacactaga aaatgccttc aatttgtgtt ttaccagaat tttgatactg   1980

gtcagaaatt ttatactgcc aacaaagaag actcaacttc tcagatctat aatgggatac   2040

attgtcatcc tctagcaact cctatataga aagttttaac tgaatatgtt acatataaga   2100

attaaattct tctcaaataa ttcttaacct cagtaatgag cctaaattta ctctgcttgg   2160

ctctctacac atggcatttc agggtataag atgtagcatt tcaatgtgta agatatatgt   2220

actaaacata tgtgttgcta tcttcatcat taacatcctt cttttctatt gcttggctgt   2280

aatttttgta aagataaatt atattgtttt tttgtatgtg tgtttgtagt atatgttcag   2340

aaggcaagca tcttcatttt gctagctttg cagaatctta aaatgtgtac tcgttatttc   2400

taatgatgta aaaaaaaatc cctagtcctg tttagcattt gactttttta tatgttttaa   2460

atgttgctgg atttttgtgc tgtttgccaa acttatacaa taaataaatg aaatattgtg   2520

ctgaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa                 2567


<210>  147
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  147


Met Glu Gln Ala Pro Pro Asp Pro Glu Arg Gln Leu Gln Pro Ala Pro 
1               5                   10                  15      


Leu Glu Pro Leu Gly Ser Pro Asp Ala Gly Leu Gly Ala Ala Val Gly 
            20                  25                  30          


Lys Glu Ala Glu Gly Ala Gly Glu Glu Ser Ser Gly Val Asp Thr Met 
        35                  40                  45              


Thr His Asn Asn Phe Trp Leu Lys Lys Ile Glu Ile Ser Val Ser Glu 
    50                  55                  60                  


Ala Glu Lys Arg Thr Gly Arg Asn Ala Met Asn Met Gln Glu Thr Tyr 
65                  70                  75                  80  


Thr Ala Tyr Leu Ile Glu Thr Arg Ser Val Glu His Thr Asp Gly Gln 
                85                  90                  95      


Ser Val Leu Thr Asp Ser Leu Trp Arg Arg Tyr Ser Glu Phe Glu Leu 
            100                 105                 110         


Leu Arg Ser Tyr Leu Leu Val Tyr Tyr Pro His Ile Val Val Pro Pro 
        115                 120                 125             


Leu Pro Glu Lys Arg Ala Glu Phe Val Trp His Lys Leu Ser Ala Asp 
    130                 135                 140                 


Asn Met Asp Pro Asp Phe Val Glu Arg Arg Arg Ile Gly Leu Glu Asn 
145                 150                 155                 160 


Phe Leu Leu Arg Ile Ala Ser His Pro Ile Leu Cys Arg Asp Lys Ile 
                165                 170                 175     


Phe Tyr Leu Phe Leu Thr Gln Glu Gly Asn Trp Lys Glu Thr Val Asn 
            180                 185                 190         


Glu Thr Gly Phe Gln Leu Lys Ala Asp Ser Arg Leu Lys Ala Leu Asn 
        195                 200                 205             


Ala Thr Phe Arg Val Lys Asn Pro Asp Lys Arg Phe Thr Asp Leu Lys 
    210                 215                 220                 


His Tyr Ser Asp Glu Leu Gln Ser Val Ile Ser His Leu Leu Arg Val 
225                 230                 235                 240 


Arg Ala Arg Val Ala Asp Arg Leu Tyr Gly Val Tyr Lys Val His Gly 
                245                 250                 255     


Asn Tyr Gly Arg Val Phe Ser Glu Trp Ser Ala Ile Glu Lys Glu Met 
            260                 265                 270         


Gly Asp Gly Leu Gln Ser Ala Gly His His Met Asp Val Tyr Ala Ser 
        275                 280                 285             


Ser Ile Asp Asp Ile Leu Glu Asp Glu Glu His Tyr Ala Asp Gln Leu 
    290                 295                 300                 


Lys Glu Tyr Leu Phe Tyr Ala Glu Ala Leu Arg Ala Val Cys Arg Lys 
305                 310                 315                 320 


His Glu Leu Met Gln Tyr Asp Leu Glu Met Ala Ala Gln Asp Leu Ala 
                325                 330                 335     


Ser Lys Lys Gln Gln Cys Glu Glu Leu Val Thr Gly Thr Val Arg Thr 
            340                 345                 350         


Phe Ser Leu Lys Gly Met Thr Thr Lys Leu Phe Gly Gln Glu Thr Pro 
        355                 360                 365             


Glu Gln Arg Glu Ala Arg Ile Lys Val Leu Glu Glu Gln Ile Asn Glu 
    370                 375                 380                 


Gly Glu Gln Gln Leu Lys Ser Lys Asn Leu Glu Gly Arg Glu Phe Val 
385                 390                 395                 400 


Lys Asn Ala Trp Ala Asp Ile Glu Arg Phe Lys Glu Gln Lys Asn Arg 
                405                 410                 415     


Asp Leu Lys Glu Ala Leu Ile Ser Tyr Ala Val Met Gln Ile Ser Met 
            420                 425                 430         


Cys Lys Lys Gly Ile Gln Val Trp Thr Asn Ala Lys Glu Cys Phe Ser 
        435                 440                 445             


Lys Met 
    450 

<210>  148
<211>  1155
<212>  DNA
<213>  Homo sapiens

<400>  148
tgataatcat ggcgcccctc ggaacaactg tattgctgtg gagcctcttg aggagttctc     60

cgggcgtgga acgggtctgt ttccgggctc gaatccagcc ctggcacggt ggcctgctcc    120

aaccgctacc ttgctctttc gagatggggc tgccacgccg ccggttcagc tccgaggccg    180

cagaatctgg tagcccagag accaagaaac ctacatttat ggatgaggaa gttcaaagca    240

tactcacgaa aatgacaggc ttgaacttgc agaagacttt taagccagct atacaagaac    300

tgaagccacc aacctataag ctaatgactc aggcacagtt ggaagaggct acaagacagg    360

cagttgaggc agctaaagta cgattaaaaa tgccaccagt tctggaagag cgagtaccaa    420

taaatgatgt gttagctgaa gataagattt tggaaggaac agaaacaacc aaatatgtgt    480

ttactgatat atcatatagc ataccacacc gggagcgttt tattgtcgtc agagaaccaa    540

gtggcacact acgcaaagcc tcttgggaag aacgggaccg aatgatacaa gtttatttcc    600

caaaagaagg tcgtaaaatt ttgacaccaa taattttcaa ggaagaaaat cttaggacta    660

tgtatagcca ggacaggcat gttgatgtcc tcaatctctg ctttgcccag tttgagccag    720

attccacaga gtatatcaag gttcatcaca agacctatga agatatagat aaacgtggaa    780

aatatgacct tttacgttca acaagatact ttggtggaat ggtgtggtat tttgtaaata    840

ataaaaagat tgatggtttg ctgattgacc agattcagag agatttaatc gatgatgcaa    900

ccaacttggt ccagctgtat cacgtgctcc atccagatgg ccagtcggct caaggggcca    960

aggatcaggc tgctgaggga ataaatttaa tcaaggtctt tgcaaaaaca gaagcacaga   1020

agggagccta tatagaacta acactgcaga cttatcaaga agcactcagt cgccattctg   1080

cagcttccta aaaatatttt aaaaatacat ttattttact aaaaaaaaaa aaaaaaaaaa   1140

aaaaaaaaaa aaaaa                                                    1155


<210>  149
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  149


Met Ala Pro Leu Gly Thr Thr Val Leu Leu Trp Ser Leu Leu Arg Ser 
1               5                   10                  15      


Ser Pro Gly Val Glu Arg Val Cys Phe Arg Ala Arg Ile Gln Pro Trp 
            20                  25                  30          


His Gly Gly Leu Leu Gln Pro Leu Pro Cys Ser Phe Glu Met Gly Leu 
        35                  40                  45              


Pro Arg Arg Arg Phe Ser Ser Glu Ala Ala Glu Ser Gly Ser Pro Glu 
    50                  55                  60                  


Thr Lys Lys Pro Thr Phe Met Asp Glu Glu Val Gln Ser Ile Leu Thr 
65                  70                  75                  80  


Lys Met Thr Gly Leu Asn Leu Gln Lys Thr Phe Lys Pro Ala Ile Gln 
                85                  90                  95      


Glu Leu Lys Pro Pro Thr Tyr Lys Leu Met Thr Gln Ala Gln Leu Glu 
            100                 105                 110         


Glu Ala Thr Arg Gln Ala Val Glu Ala Ala Lys Val Arg Leu Lys Met 
        115                 120                 125             


Pro Pro Val Leu Glu Glu Arg Val Pro Ile Asn Asp Val Leu Ala Glu 
    130                 135                 140                 


Asp Lys Ile Leu Glu Gly Thr Glu Thr Thr Lys Tyr Val Phe Thr Asp 
145                 150                 155                 160 


Ile Ser Tyr Ser Ile Pro His Arg Glu Arg Phe Ile Val Val Arg Glu 
                165                 170                 175     


Pro Ser Gly Thr Leu Arg Lys Ala Ser Trp Glu Glu Arg Asp Arg Met 
            180                 185                 190         


Ile Gln Val Tyr Phe Pro Lys Glu Gly Arg Lys Ile Leu Thr Pro Ile 
        195                 200                 205             


Ile Phe Lys Glu Glu Asn Leu Arg Thr Met Tyr Ser Gln Asp Arg His 
    210                 215                 220                 


Val Asp Val Leu Asn Leu Cys Phe Ala Gln Phe Glu Pro Asp Ser Thr 
225                 230                 235                 240 


Glu Tyr Ile Lys Val His His Lys Thr Tyr Glu Asp Ile Asp Lys Arg 
                245                 250                 255     


Gly Lys Tyr Asp Leu Leu Arg Ser Thr Arg Tyr Phe Gly Gly Met Val 
            260                 265                 270         


Trp Tyr Phe Val Asn Asn Lys Lys Ile Asp Gly Leu Leu Ile Asp Gln 
        275                 280                 285             


Ile Gln Arg Asp Leu Ile Asp Asp Ala Thr Asn Leu Val Gln Leu Tyr 
    290                 295                 300                 


His Val Leu His Pro Asp Gly Gln Ser Ala Gln Gly Ala Lys Asp Gln 
305                 310                 315                 320 


Ala Ala Glu Gly Ile Asn Leu Ile Lys Val Phe Ala Lys Thr Glu Ala 
                325                 330                 335     


Gln Lys Gly Ala Tyr Ile Glu Leu Thr Leu Gln Thr Tyr Gln Glu Ala 
            340                 345                 350         


Leu Ser Arg His Ser Ala Ala Ser 
        355                 360 

<210>  150
<211>  3142
<212>  DNA
<213>  Homo sapiens

<400>  150
gactatcgcg agaatcggct cccggaagtt ccacgtcagt cagtctgacg gtcagtggat     60

cggtgggttt atctcaaggc ctgagtagcc ggtaacaaac gagggttccc gggattggac    120

cgacgcagcc atgcctctgc gacttgatat caaaagaaag ctaactgcta gatctgatcg    180

agttaagagt gtggatctgc atcctacaga gccatggatg ttggcaagtc tttacaatgg    240

cagtgtgtgt gtttggaatc atgaaacaca gacactggtg aagacatttg aagtatgtga    300

tcttcctgtt cgagctgcaa agtttgttgc aaggaagaat tgggttgtga caggagcgga    360

tgacatgcag attagagtgt tcaattacaa tactctggag agagttcata tgtttgaagc    420

acactcagac tacattcgct gtattgctgt tcatccaacc cagcctttca ttctaactag    480

cagtgatgac atgcttatta agctctggga ctgggataaa aaatggtctt gctcacaagt    540

gtttgaagga cacacccatt atgttatgca gattgtgatc aaccccaaag ataacaatca    600

gtttgccagt gcctctttgg acaggactat caaggtgtgg cagttgggct cttcgtcacc    660

aaacttcact ttggaaggac atgagaaagg cgtgaattgc attgattact acagtggtgg    720

ggacaagcca tacctcattt caggtgcaga tgaccgtctt gttaaaatat gggattatca    780

gaataaaaca tgtgtgcaga cactggaagg acatgcccaa aatgtgtctt gtgccagctt    840

tcatcctgag ttgccaatca ttatcacagg ttcagaagat ggaacagtac gtatttggca    900

ttcaagcacc taccggcttg agagcacact gaattatgga atggagaggg tatggtgcgt    960

ggccagtcta agagggtcaa acaatgtcgc tttgggctat gatgaaggga gcatcattgt   1020

taagcttggt cgggaggaac ctgccatgtc catggatgcc aatggaaaga taatttgggc   1080

caagcattca gaagtccagc aggccaacct aaaagcaatg ggagatgctg aaattaaaga   1140

tggtgaaaga ttgccactgg cagtaaagga tatgggcagt tgtgaaatat accctcagac   1200

tattcagcac aatcctaatg ggcggtttgt ggtggtgtgt ggtgatgggg agtatatcat   1260

ctacacagca atggcattga gaaacaagag ctttggatct gctcaggagt ttgcatgggc   1320

ccacgattct tcagagtatg caataagaga gagcaacagc attgtaaaga tatttaagaa   1380

ctttaaggaa aaaaaatcat ttaaaccaga ttttggagca gaaagtatct acggcggctt   1440

cttattggga gtcagatctg taaatggctt agccttctat gactgggaca atacagaact   1500

catacgaaga attgaaattc agcccaaaca tattttctgg tctgactctg gagagctagt   1560

ctgtattgct actgaggaat cattttttat ccttaagtat ctgtcagaaa aagtcttggc   1620

tgcacaggaa acacatgagg gagttactga agatggcatt gaagatgcct ttgaggttct   1680

tggtgagatt caggaaattg tgaaaacagg gctttgggta ggcgattgct tcatttacac   1740

aagttctgtg aacagattaa attattatgt tggaggagaa atagtcacca ttgcccactt   1800

ggacaggacg atgtatctcc taggctacat tcctaaagac aacaggcttt atctggggga   1860

taaagaattg aacatcatta gctattccct gctggtttca gtcctggaat accagacagc   1920

tgtcatgcgg agggacttta gcatggctga taaggtcctt cctaccattc caaaagaaca   1980

gaggaccaga gttgcacact ttttggaaaa gcagggcttc aagcagcaag ctcttacagt   2040

atccacagat cctgagcatc gttttgagct tgctcttcag cttggagagt taaaaattgc   2100

ataccagtta gcagtggaag cagagtcaga acagaagtgg aaacaacttg ctgaacttgc   2160

cattagtaaa tgtcagtttg gcctagccca ggagtgcctg catcatgcac aggattatgg   2220

gggcctgctg cttttggcca ctgcctctgg aaatgctaat atggtgaaca agctagcaga   2280

gggtgcggag agagatggca aaaataatgt ggcattcatg agctactttt tacagggcaa   2340

ggttgatgcc tgcctagagc tcttaattag aactggacgg ctgccagaag ctgccttctt   2400

ggcccgaact tacttaccca gtcaggtttc aagggtagtg aaactctgga gagagaatct   2460

ctcaaaagtc aatcagaaag cagcagaatc ccttgctgac ccaacagagt atgaaaacct   2520

gttccctgga ttaaaagaag cctttgttgt tgaagaatgg gtgaaggaaa cacatgctga   2580

tctgtggcca gccaaacaat acccacttgt cacgccaaat gaagagagaa atgtcatgga   2640

agagggaaaa gactttcagc cctcaagatc tacagctcaa caggaacttg atgggaaacc   2700

tgcttctcct actccggtta ttgtggcctc ccacacagcc aacaaagaag aaaagagttt   2760

actcgaacta gaagtagatt tggataattt ggaattagaa gatattgaca caacagatat   2820

caatctggat gaagatattt tggatgattg actgtaatgc tttccattta cctgactaaa   2880

cagatcatta ttatatatag gtattgattg ctaccctgac cacagtgctt tggactatga   2940

gaaacttctt agatttttat atgtaaatgc tgtggaccac tgggagcaca atgcccacat   3000

catcttaaga agagtttatg tgcagcattt aaatcactgt gttttccttg ttaactaaaa   3060

cagacatggg ctttgatttt tttcatacta ttagaccata tctcataaaa ccttttgaat   3120

taaaaaaaaa aaaaaaaaaa aa                                            3142


<210>  151
<211>  906
<212>  PRT
<213>  Homo sapiens

<400>  151


Met Pro Leu Arg Leu Asp Ile Lys Arg Lys Leu Thr Ala Arg Ser Asp 
1               5                   10                  15      


Arg Val Lys Ser Val Asp Leu His Pro Thr Glu Pro Trp Met Leu Ala 
            20                  25                  30          


Ser Leu Tyr Asn Gly Ser Val Cys Val Trp Asn His Glu Thr Gln Thr 
        35                  40                  45              


Leu Val Lys Thr Phe Glu Val Cys Asp Leu Pro Val Arg Ala Ala Lys 
    50                  55                  60                  


Phe Val Ala Arg Lys Asn Trp Val Val Thr Gly Ala Asp Asp Met Gln 
65                  70                  75                  80  


Ile Arg Val Phe Asn Tyr Asn Thr Leu Glu Arg Val His Met Phe Glu 
                85                  90                  95      


Ala His Ser Asp Tyr Ile Arg Cys Ile Ala Val His Pro Thr Gln Pro 
            100                 105                 110         


Phe Ile Leu Thr Ser Ser Asp Asp Met Leu Ile Lys Leu Trp Asp Trp 
        115                 120                 125             


Asp Lys Lys Trp Ser Cys Ser Gln Val Phe Glu Gly His Thr His Tyr 
    130                 135                 140                 


Val Met Gln Ile Val Ile Asn Pro Lys Asp Asn Asn Gln Phe Ala Ser 
145                 150                 155                 160 


Ala Ser Leu Asp Arg Thr Ile Lys Val Trp Gln Leu Gly Ser Ser Ser 
                165                 170                 175     


Pro Asn Phe Thr Leu Glu Gly His Glu Lys Gly Val Asn Cys Ile Asp 
            180                 185                 190         


Tyr Tyr Ser Gly Gly Asp Lys Pro Tyr Leu Ile Ser Gly Ala Asp Asp 
        195                 200                 205             


Arg Leu Val Lys Ile Trp Asp Tyr Gln Asn Lys Thr Cys Val Gln Thr 
    210                 215                 220                 


Leu Glu Gly His Ala Gln Asn Val Ser Cys Ala Ser Phe His Pro Glu 
225                 230                 235                 240 


Leu Pro Ile Ile Ile Thr Gly Ser Glu Asp Gly Thr Val Arg Ile Trp 
                245                 250                 255     


His Ser Ser Thr Tyr Arg Leu Glu Ser Thr Leu Asn Tyr Gly Met Glu 
            260                 265                 270         


Arg Val Trp Cys Val Ala Ser Leu Arg Gly Ser Asn Asn Val Ala Leu 
        275                 280                 285             


Gly Tyr Asp Glu Gly Ser Ile Ile Val Lys Leu Gly Arg Glu Glu Pro 
    290                 295                 300                 


Ala Met Ser Met Asp Ala Asn Gly Lys Ile Ile Trp Ala Lys His Ser 
305                 310                 315                 320 


Glu Val Gln Gln Ala Asn Leu Lys Ala Met Gly Asp Ala Glu Ile Lys 
                325                 330                 335     


Asp Gly Glu Arg Leu Pro Leu Ala Val Lys Asp Met Gly Ser Cys Glu 
            340                 345                 350         


Ile Tyr Pro Gln Thr Ile Gln His Asn Pro Asn Gly Arg Phe Val Val 
        355                 360                 365             


Val Cys Gly Asp Gly Glu Tyr Ile Ile Tyr Thr Ala Met Ala Leu Arg 
    370                 375                 380                 


Asn Lys Ser Phe Gly Ser Ala Gln Glu Phe Ala Trp Ala His Asp Ser 
385                 390                 395                 400 


Ser Glu Tyr Ala Ile Arg Glu Ser Asn Ser Ile Val Lys Ile Phe Lys 
                405                 410                 415     


Asn Phe Lys Glu Lys Lys Ser Phe Lys Pro Asp Phe Gly Ala Glu Ser 
            420                 425                 430         


Ile Tyr Gly Gly Phe Leu Leu Gly Val Arg Ser Val Asn Gly Leu Ala 
        435                 440                 445             


Phe Tyr Asp Trp Asp Asn Thr Glu Leu Ile Arg Arg Ile Glu Ile Gln 
    450                 455                 460                 


Pro Lys His Ile Phe Trp Ser Asp Ser Gly Glu Leu Val Cys Ile Ala 
465                 470                 475                 480 


Thr Glu Glu Ser Phe Phe Ile Leu Lys Tyr Leu Ser Glu Lys Val Leu 
                485                 490                 495     


Ala Ala Gln Glu Thr His Glu Gly Val Thr Glu Asp Gly Ile Glu Asp 
            500                 505                 510         


Ala Phe Glu Val Leu Gly Glu Ile Gln Glu Ile Val Lys Thr Gly Leu 
        515                 520                 525             


Trp Val Gly Asp Cys Phe Ile Tyr Thr Ser Ser Val Asn Arg Leu Asn 
    530                 535                 540                 


Tyr Tyr Val Gly Gly Glu Ile Val Thr Ile Ala His Leu Asp Arg Thr 
545                 550                 555                 560 


Met Tyr Leu Leu Gly Tyr Ile Pro Lys Asp Asn Arg Leu Tyr Leu Gly 
                565                 570                 575     


Asp Lys Glu Leu Asn Ile Ile Ser Tyr Ser Leu Leu Val Ser Val Leu 
            580                 585                 590         


Glu Tyr Gln Thr Ala Val Met Arg Arg Asp Phe Ser Met Ala Asp Lys 
        595                 600                 605             


Val Leu Pro Thr Ile Pro Lys Glu Gln Arg Thr Arg Val Ala His Phe 
    610                 615                 620                 


Leu Glu Lys Gln Gly Phe Lys Gln Gln Ala Leu Thr Val Ser Thr Asp 
625                 630                 635                 640 


Pro Glu His Arg Phe Glu Leu Ala Leu Gln Leu Gly Glu Leu Lys Ile 
                645                 650                 655     


Ala Tyr Gln Leu Ala Val Glu Ala Glu Ser Glu Gln Lys Trp Lys Gln 
            660                 665                 670         


Leu Ala Glu Leu Ala Ile Ser Lys Cys Gln Phe Gly Leu Ala Gln Glu 
        675                 680                 685             


Cys Leu His His Ala Gln Asp Tyr Gly Gly Leu Leu Leu Leu Ala Thr 
    690                 695                 700                 


Ala Ser Gly Asn Ala Asn Met Val Asn Lys Leu Ala Glu Gly Ala Glu 
705                 710                 715                 720 


Arg Asp Gly Lys Asn Asn Val Ala Phe Met Ser Tyr Phe Leu Gln Gly 
                725                 730                 735     


Lys Val Asp Ala Cys Leu Glu Leu Leu Ile Arg Thr Gly Arg Leu Pro 
            740                 745                 750         


Glu Ala Ala Phe Leu Ala Arg Thr Tyr Leu Pro Ser Gln Val Ser Arg 
        755                 760                 765             


Val Val Lys Leu Trp Arg Glu Asn Leu Ser Lys Val Asn Gln Lys Ala 
    770                 775                 780                 


Ala Glu Ser Leu Ala Asp Pro Thr Glu Tyr Glu Asn Leu Phe Pro Gly 
785                 790                 795                 800 


Leu Lys Glu Ala Phe Val Val Glu Glu Trp Val Lys Glu Thr His Ala 
                805                 810                 815     


Asp Leu Trp Pro Ala Lys Gln Tyr Pro Leu Val Thr Pro Asn Glu Glu 
            820                 825                 830         


Arg Asn Val Met Glu Glu Gly Lys Asp Phe Gln Pro Ser Arg Ser Thr 
        835                 840                 845             


Ala Gln Gln Glu Leu Asp Gly Lys Pro Ala Ser Pro Thr Pro Val Ile 
    850                 855                 860                 


Val Ala Ser His Thr Ala Asn Lys Glu Glu Lys Ser Leu Leu Glu Leu 
865                 870                 875                 880 


Glu Val Asp Leu Asp Asn Leu Glu Leu Glu Asp Ile Asp Thr Thr Asp 
                885                 890                 895     


Ile Asn Leu Asp Glu Asp Ile Leu Asp Asp 
            900                 905     

<210>  152
<211>  700
<212>  DNA
<213>  Homo sapiens

<400>  152
cctgctcctt gccatccacc acaaaccctc accgaaccag tggccaccac catgacaagg     60

gaccagaatg gaacctggga gatggagagt aatgaaaact ttgagggcta catgaaggcc    120

ctggatattg attttgccac ccgcaagatt gcagtacgtc tcactcagac gaaggttatt    180

gatcaagatg gtgataactt caagacaaaa accactagca cattccgcaa ctatgatgtg    240

gatttcactg ttggagtaga gtttgacgag tacacaaaga gcctggataa ccggcatgtt    300

aaggcactgg tcacctggga aggtgatgtc cttgtgtgtg tgcaaaaggg ggagaaggag    360

aaccgcggct ggaagcagtg gattgagggg gacaagctgt acctggagct gacctgtggt    420

gaccaggtgt gccgtcaagt gttcaaaaag aaatgatggc gacgtgggag gcctgccaag    480

cacaagctcc ccactgccca cactgagtgg tctactggct ttgagaaaca gctgtgggga    540

ccttcccact cttgacagag ccccattaag gcatctgggt gggttttaaa cagaatgcct    600

atgtagcagt gatagacata ttcccctcct ttgaaaccta gcattaaatg gaaaaacaaa    660

aattactccc atattttgaa accctttaaa aaaaaaaaaa                          700


<210>  153
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  153


Met Thr Arg Asp Gln Asn Gly Thr Trp Glu Met Glu Ser Asn Glu Asn 
1               5                   10                  15      


Phe Glu Gly Tyr Met Lys Ala Leu Asp Ile Asp Phe Ala Thr Arg Lys 
            20                  25                  30          


Ile Ala Val Arg Leu Thr Gln Thr Lys Val Ile Asp Gln Asp Gly Asp 
        35                  40                  45              


Asn Phe Lys Thr Lys Thr Thr Ser Thr Phe Arg Asn Tyr Asp Val Asp 
    50                  55                  60                  


Phe Thr Val Gly Val Glu Phe Asp Glu Tyr Thr Lys Ser Leu Asp Asn 
65                  70                  75                  80  


Arg His Val Lys Ala Leu Val Thr Trp Glu Gly Asp Val Leu Val Cys 
                85                  90                  95      


Val Gln Lys Gly Glu Lys Glu Asn Arg Gly Trp Lys Gln Trp Ile Glu 
            100                 105                 110         


Gly Asp Lys Leu Tyr Leu Glu Leu Thr Cys Gly Asp Gln Val Cys Arg 
        115                 120                 125             


Gln Val Phe Lys Lys Lys 
    130                 

<210>  154
<211>  916
<212>  DNA
<213>  Homo sapiens

<400>  154
aaacgaactg aacgtctgaa acgaaggtgg cgcggcctgg acaaacctga cccttcgaca     60

tcccccgccc ctgcgcccgc cctcgctaag cggggaggag cgaccgctac aatggatcct    120

cccgcaggct ttgtgcgcgc tgggaatcca gctgtcgccg ccccgcagag ccccctgtcc    180

ccggagggcg ctcatttccg ggccgcccac cacccgcgta gcaccggcag ccgctgtccc    240

ggcagtctcc agccgtcccg cccgcttgtg gccaactggc tccagtcact ccccgaaatg    300

ccagtcgact tcactgggta ctggaagatg ttggtcaacg agaatttcga ggagtacctg    360

cgcgccctcg acgtcaatgt ggccttgcgc aaaatcgcca acttgctgaa gccagacaaa    420

gagatcgtgc aggacggtga ccatatgatc atccgcacgc tgagcacttt taggaactac    480

atcatggact tccaggttgg gaaggagttt gaggaggatc tgacaggcat agatgaccgc    540

aagtgcatga caacagtgag ctgggacgga gacaagctcc agtgtgtgca gaagggtgag    600

aaggaggggc gtggctggac ccagtggatc gagggtgatg agctgcacct ggagatgaga    660

gtggaaggtg tggtctgcaa gcaagtattc aagaaggtgc agtgaggccc aggcagacaa    720

ccttgtccca aggaatcagc aggatgtgtg ggccaggatc cccctctttg cacagcatga    780

ggcaaaaatg tccagccacc cccaggcatc tgttagcaga gtctgtctct tggctttgtc    840

acttttcctt ttcttaaaac aaagccatgc caataaagtg atctgtgttc aaaacgtcaa    900

aaaaaaaaaa aaaaaa                                                    916


<210>  155
<211>  197
<212>  PRT
<213>  Homo sapiens

<400>  155


Met Asp Pro Pro Ala Gly Phe Val Arg Ala Gly Asn Pro Ala Val Ala 
1               5                   10                  15      


Ala Pro Gln Ser Pro Leu Ser Pro Glu Gly Ala His Phe Arg Ala Ala 
            20                  25                  30          


His His Pro Arg Ser Thr Gly Ser Arg Cys Pro Gly Ser Leu Gln Pro 
        35                  40                  45              


Ser Arg Pro Leu Val Ala Asn Trp Leu Gln Ser Leu Pro Glu Met Pro 
    50                  55                  60                  


Val Asp Phe Thr Gly Tyr Trp Lys Met Leu Val Asn Glu Asn Phe Glu 
65                  70                  75                  80  


Glu Tyr Leu Arg Ala Leu Asp Val Asn Val Ala Leu Arg Lys Ile Ala 
                85                  90                  95      


Asn Leu Leu Lys Pro Asp Lys Glu Ile Val Gln Asp Gly Asp His Met 
            100                 105                 110         


Ile Ile Arg Thr Leu Ser Thr Phe Arg Asn Tyr Ile Met Asp Phe Gln 
        115                 120                 125             


Val Gly Lys Glu Phe Glu Glu Asp Leu Thr Gly Ile Asp Asp Arg Lys 
    130                 135                 140                 


Cys Met Thr Thr Val Ser Trp Asp Gly Asp Lys Leu Gln Cys Val Gln 
145                 150                 155                 160 


Lys Gly Glu Lys Glu Gly Arg Gly Trp Thr Gln Trp Ile Glu Gly Asp 
                165                 170                 175     


Glu Leu His Leu Glu Met Arg Val Glu Gly Val Val Cys Lys Gln Val 
            180                 185                 190         


Phe Lys Lys Val Gln 
        195         

<210>  156
<211>  1383
<212>  DNA
<213>  Homo sapiens

<400>  156
atggatatgg aggtcttggg ccaggaacaa agctccgaac agctggattt agaggagatc     60

tcaaggaaaa tttcattcct tgacaaatgg agggaaatct ttagttatca caggttggga    120

accaataatt caactcctca gaatcatgaa ggcaaccata catctgctga tgaaaatgaa    180

gatggaacag gactatctca gcccaaagga caaggacatt tgccatcaag tggcctttgt    240

tctattccca acccctctat catctcttca aaattgggtg gctttcctat ctccctagca    300

atggccacga agctgcggca gatcctgttt ggaaacacag tccatgtctt tagctataac    360

tggaaaaagg cctatttcag gttccatgat ccttcttctg aactagcttt cactctggaa    420

gtgggaaagg gaggggcccg aagcattcag atggctgtgc aaggatccat catcaaatac    480

ttgttgttta ccaggaaagg aaaagactgt aaccttggca acttatgtga aataagcaag    540

aaggagcagg agcaagcctt ggccgcggcg cttgctggca tcctgtgggc tgcaggagca    600

gctcagaagg ccaccatctg tcttgtcact gaggacattt acgttgcgtc gactccggac    660

tactctgtgg acaatttcac tgagcgactc cagctgtttg aatttttaga gaaagaagcc    720

gctgagaaat tcatctacga tcacttacta tgtttcagag gggaaggaag ccatggtgtc    780

atcctgtttc tgtacagcct gatcttctct agaacatttg aaaggcttca aatggaccta    840

gatgtcacca ccactcagct gctacaacca aatgctggag gctttctgtg caggcaggca    900

gttctgaaca tgattttaac tggaagagca agtcccaatg tcttcaatgg ctgtgaggaa    960

ggaaagtctc aggaaacact acatggagtc ctgacccgca gtgatgttgg ctatttgcag   1020

tggggtaagg atgcctcgga agatgacaga ctctcacagg tgggcagcat gctgaagact   1080

cccaaattac ctatttggct gtgcaacatc aatggaaatt acagcatcct tttttgcaca   1140

aacaggcagc tcttatcaga ctggaaaatg gaacgtctct ttgatctgta cttttacagt   1200

ggccaaccct cacagaaaaa gcttgtgcgt cttacaatag atactcactc ccatcactgg   1260

gaaagagacc aacaggaaga gaaacatgga ccaagacgac ggttttcacc agtggagatg   1320

gcaatcagaa ccaagtggag cgaggccacc atcaactgga atgggaccgt tcccttcttc   1380

taa                                                                 1383


<210>  157
<211>  460
<212>  PRT
<213>  Homo sapiens

<400>  157


Met Asp Met Glu Val Leu Gly Gln Glu Gln Ser Ser Glu Gln Leu Asp 
1               5                   10                  15      


Leu Glu Glu Ile Ser Arg Lys Ile Ser Phe Leu Asp Lys Trp Arg Glu 
            20                  25                  30          


Ile Phe Ser Tyr His Arg Leu Gly Thr Asn Asn Ser Thr Pro Gln Asn 
        35                  40                  45              


His Glu Gly Asn His Thr Ser Ala Asp Glu Asn Glu Asp Gly Thr Gly 
    50                  55                  60                  


Leu Ser Gln Pro Lys Gly Gln Gly His Leu Pro Ser Ser Gly Leu Cys 
65                  70                  75                  80  


Ser Ile Pro Asn Pro Ser Ile Ile Ser Ser Lys Leu Gly Gly Phe Pro 
                85                  90                  95      


Ile Ser Leu Ala Met Ala Thr Lys Leu Arg Gln Ile Leu Phe Gly Asn 
            100                 105                 110         


Thr Val His Val Phe Ser Tyr Asn Trp Lys Lys Ala Tyr Phe Arg Phe 
        115                 120                 125             


His Asp Pro Ser Ser Glu Leu Ala Phe Thr Leu Glu Val Gly Lys Gly 
    130                 135                 140                 


Gly Ala Arg Ser Ile Gln Met Ala Val Gln Gly Ser Ile Ile Lys Tyr 
145                 150                 155                 160 


Leu Leu Phe Thr Arg Lys Gly Lys Asp Cys Asn Leu Gly Asn Leu Cys 
                165                 170                 175     


Glu Ile Ser Lys Lys Glu Gln Glu Gln Ala Leu Ala Ala Ala Leu Ala 
            180                 185                 190         


Gly Ile Leu Trp Ala Ala Gly Ala Ala Gln Lys Ala Thr Ile Cys Leu 
        195                 200                 205             


Val Thr Glu Asp Ile Tyr Val Ala Ser Thr Pro Asp Tyr Ser Val Asp 
    210                 215                 220                 


Asn Phe Thr Glu Arg Leu Gln Leu Phe Glu Phe Leu Glu Lys Glu Ala 
225                 230                 235                 240 


Ala Glu Lys Phe Ile Tyr Asp His Leu Leu Cys Phe Arg Gly Glu Gly 
                245                 250                 255     


Ser His Gly Val Ile Leu Phe Leu Tyr Ser Leu Ile Phe Ser Arg Thr 
            260                 265                 270         


Phe Glu Arg Leu Gln Met Asp Leu Asp Val Thr Thr Thr Gln Leu Leu 
        275                 280                 285             


Gln Pro Asn Ala Gly Gly Phe Leu Cys Arg Gln Ala Val Leu Asn Met 
    290                 295                 300                 


Ile Leu Thr Gly Arg Ala Ser Pro Asn Val Phe Asn Gly Cys Glu Glu 
305                 310                 315                 320 


Gly Lys Ser Gln Glu Thr Leu His Gly Val Leu Thr Arg Ser Asp Val 
                325                 330                 335     


Gly Tyr Leu Gln Trp Gly Lys Asp Ala Ser Glu Asp Asp Arg Leu Ser 
            340                 345                 350         


Gln Val Gly Ser Met Leu Lys Thr Pro Lys Leu Pro Ile Trp Leu Cys 
        355                 360                 365             


Asn Ile Asn Gly Asn Tyr Ser Ile Leu Phe Cys Thr Asn Arg Gln Leu 
    370                 375                 380                 


Leu Ser Asp Trp Lys Met Glu Arg Leu Phe Asp Leu Tyr Phe Tyr Ser 
385                 390                 395                 400 


Gly Gln Pro Ser Gln Lys Lys Leu Val Arg Leu Thr Ile Asp Thr His 
                405                 410                 415     


Ser His His Trp Glu Arg Asp Gln Gln Glu Glu Lys His Gly Pro Arg 
            420                 425                 430         


Arg Arg Phe Ser Pro Val Glu Met Ala Ile Arg Thr Lys Trp Ser Glu 
        435                 440                 445             


Ala Thr Ile Asn Trp Asn Gly Thr Val Pro Phe Phe 
    450                 455                 460 

<210>  158
<211>  2551
<212>  DNA
<213>  Homo sapiens

<400>  158
atcagcccaa aggtaggctc aggctccgac ggtggccggc gggggtcacg aggcttcgta     60

gtggaggaac gggtttggcg tgtgggacgc agctgcctct gtactgggga gtcacggagt    120

ggccgggctc cagggacatg gcggcggcct ctgcggtgtc ggtgctgctg gtggcggcgg    180

agaggaaccg gtggcatcgt ctcccgagcc tgctcctgcc gccgaggaca tgggtgtgga    240

ggcaaagaac catgaagtac acaacagcca caggaagaaa cattaccaag gtcctcattg    300

caaacagagg agaaattgcc tgcagggtga tgcgcacagc caaaaaactg ggtgtacaga    360

ctgtggcggt ttatagtgag gctgacagaa attccatgca tgtagatatg gcagatgaag    420

catattccat cggccccgct ccctcccagc agagctacct atctatggag aaaatcattc    480

aagtggccaa gacctctgct gcacaggcta tccatccagg atgcggtttt ctctcagaaa    540

acatggaatt tgctgaactt tgtaagcaag aaggaattat ttttataggc cctcctccat    600

ctgcaattag agacatgggt ataaagagca catccaaatc cataatggct gctgctggag    660

tacctgttgt ggagggttat catggtgagg accaatcaga ccagtgcctg aaggaacacg    720

ccaggagaat tggctatcct gtcatgatta aagccgtccg gggtggagga ggaaaaggaa    780

tgaggattgt tagatcagaa caagaatttc aagaacagtt agagtcagca cggagagaag    840

ctaagaagtc tttcaatgat gatgctatgc tgatcgagaa gtttgtagac acaccgaggc    900

atgtagaagt ccaggtgttt ggtgatcacc atggcaatgc tgtgtacttg tttgaaagag    960

actgtagtgt gcagaggcga catcagaaga tcattgagga ggccccagcg cctggtatta   1020

aatctgaagt aagaaaaaag ctgggagaag ctgcagtcag agctgctaaa gctgtaaatt   1080

atgttggagc agggactgtg gagtttatta tggactcaaa acataatttc tgtttcatgg   1140

agatgaatac aaggctgcaa gtggaacatc ctgttactga gatgatcaca ggaactgact   1200

tggtggagtg gcagcttaga attgcagcag gagagaagat tcctttgagc caggaagaaa   1260

taactctgca gggccatgcc ttcgaagcta gaatatatgc agaagatcct agcaataact   1320

tcatgcctgt ggcaggccca ttagtgcacc tctctactcc tcgagcagac ccttccacca   1380

ggattgaaac tggagtacgg caaggagacg aagtttccgt gcattatgac cccatgattg   1440

cgaagctggt cgtgtgggca gcagatcgcc aggcggcatt gacaaaactg aggtacagcc   1500

ttcgtcagta caatattgtt ggactgcaca ccaacattga cttcttactc aacctgtctg   1560

gccacccaga gtttgaagct gggaacgtgc acactgattt catccctcaa caccacaaac   1620

agttgttgct cagtcggaag gctgcagcca aagagtcttt atgccaggca gccctgggtc   1680

tcatcctcaa ggagaaagcc atgaccgaca ctttcactct tcaggcacat gatcaattct   1740

ctccattttc gtctagcagt ggaagaagac tgaatatctc gtataccaga aacatgactc   1800

ttaaagatgg taaaaacaat gtagccatag ctgtaacgta taaccatgat gggtcttata   1860

gcatgcagat tgaagataaa actttccaag tccttggtaa tctttacagc gagggagact   1920

gcacttacct gaaatgttct gttaatggag ttgctagtaa agcgaagctg attatcctgg   1980

aaaacactat ttacctattt tccaaggaag gaagtattga gattgacatt ccagtcccca   2040

aatacttatc ttctgtgagc tcacaagaaa ctcagggcgg ccccttagct cctatgactg   2100

gaaccattga aaaggtgttt gtcaaagctg gagacaaagt gaaagcggga gattccctca   2160

tggttatgat cgccatgaag atggagcata ccataaagtc tccaaaggat ggcacagtaa   2220

agaaagtgtt ctacagagaa ggtgctcagg ccaacagaca cactccttta gtcgagtttg   2280

aggaggaaga atcagacaaa agggaatcgg aataaactcc agcaaggaaa tggccagtta   2340

agtagtgtct tctctctcca ccaaaaagag gaagtgcctc cagcttttct gggggtctca   2400

taaagagcag ttttactaaa tgattgtatg cttatgctga acacctttca tattggagaa   2460

tcatgcattt gggtcactaa ttatctcaaa atatttcata ctaataaagt tgaattattt   2520

tttattggaa gccaaaaaaa aaaaaaaaaa a                                  2551


<210>  159
<211>  725
<212>  PRT
<213>  Homo sapiens

<400>  159


Met Ala Ala Ala Ser Ala Val Ser Val Leu Leu Val Ala Ala Glu Arg 
1               5                   10                  15      


Asn Arg Trp His Arg Leu Pro Ser Leu Leu Leu Pro Pro Arg Thr Trp 
            20                  25                  30          


Val Trp Arg Gln Arg Thr Met Lys Tyr Thr Thr Ala Thr Gly Arg Asn 
        35                  40                  45              


Ile Thr Lys Val Leu Ile Ala Asn Arg Gly Glu Ile Ala Cys Arg Val 
    50                  55                  60                  


Met Arg Thr Ala Lys Lys Leu Gly Val Gln Thr Val Ala Val Tyr Ser 
65                  70                  75                  80  


Glu Ala Asp Arg Asn Ser Met His Val Asp Met Ala Asp Glu Ala Tyr 
                85                  90                  95      


Ser Ile Gly Pro Ala Pro Ser Gln Gln Ser Tyr Leu Ser Met Glu Lys 
            100                 105                 110         


Ile Ile Gln Val Ala Lys Thr Ser Ala Ala Gln Ala Ile His Pro Gly 
        115                 120                 125             


Cys Gly Phe Leu Ser Glu Asn Met Glu Phe Ala Glu Leu Cys Lys Gln 
    130                 135                 140                 


Glu Gly Ile Ile Phe Ile Gly Pro Pro Pro Ser Ala Ile Arg Asp Met 
145                 150                 155                 160 


Gly Ile Lys Ser Thr Ser Lys Ser Ile Met Ala Ala Ala Gly Val Pro 
                165                 170                 175     


Val Val Glu Gly Tyr His Gly Glu Asp Gln Ser Asp Gln Cys Leu Lys 
            180                 185                 190         


Glu His Ala Arg Arg Ile Gly Tyr Pro Val Met Ile Lys Ala Val Arg 
        195                 200                 205             


Gly Gly Gly Gly Lys Gly Met Arg Ile Val Arg Ser Glu Gln Glu Phe 
    210                 215                 220                 


Gln Glu Gln Leu Glu Ser Ala Arg Arg Glu Ala Lys Lys Ser Phe Asn 
225                 230                 235                 240 


Asp Asp Ala Met Leu Ile Glu Lys Phe Val Asp Thr Pro Arg His Val 
                245                 250                 255     


Glu Val Gln Val Phe Gly Asp His His Gly Asn Ala Val Tyr Leu Phe 
            260                 265                 270         


Glu Arg Asp Cys Ser Val Gln Arg Arg His Gln Lys Ile Ile Glu Glu 
        275                 280                 285             


Ala Pro Ala Pro Gly Ile Lys Ser Glu Val Arg Lys Lys Leu Gly Glu 
    290                 295                 300                 


Ala Ala Val Arg Ala Ala Lys Ala Val Asn Tyr Val Gly Ala Gly Thr 
305                 310                 315                 320 


Val Glu Phe Ile Met Asp Ser Lys His Asn Phe Cys Phe Met Glu Met 
                325                 330                 335     


Asn Thr Arg Leu Gln Val Glu His Pro Val Thr Glu Met Ile Thr Gly 
            340                 345                 350         


Thr Asp Leu Val Glu Trp Gln Leu Arg Ile Ala Ala Gly Glu Lys Ile 
        355                 360                 365             


Pro Leu Ser Gln Glu Glu Ile Thr Leu Gln Gly His Ala Phe Glu Ala 
    370                 375                 380                 


Arg Ile Tyr Ala Glu Asp Pro Ser Asn Asn Phe Met Pro Val Ala Gly 
385                 390                 395                 400 


Pro Leu Val His Leu Ser Thr Pro Arg Ala Asp Pro Ser Thr Arg Ile 
                405                 410                 415     


Glu Thr Gly Val Arg Gln Gly Asp Glu Val Ser Val His Tyr Asp Pro 
            420                 425                 430         


Met Ile Ala Lys Leu Val Val Trp Ala Ala Asp Arg Gln Ala Ala Leu 
        435                 440                 445             


Thr Lys Leu Arg Tyr Ser Leu Arg Gln Tyr Asn Ile Val Gly Leu His 
    450                 455                 460                 


Thr Asn Ile Asp Phe Leu Leu Asn Leu Ser Gly His Pro Glu Phe Glu 
465                 470                 475                 480 


Ala Gly Asn Val His Thr Asp Phe Ile Pro Gln His His Lys Gln Leu 
                485                 490                 495     


Leu Leu Ser Arg Lys Ala Ala Ala Lys Glu Ser Leu Cys Gln Ala Ala 
            500                 505                 510         


Leu Gly Leu Ile Leu Lys Glu Lys Ala Met Thr Asp Thr Phe Thr Leu 
        515                 520                 525             


Gln Ala His Asp Gln Phe Ser Pro Phe Ser Ser Ser Ser Gly Arg Arg 
    530                 535                 540                 


Leu Asn Ile Ser Tyr Thr Arg Asn Met Thr Leu Lys Asp Gly Lys Asn 
545                 550                 555                 560 


Asn Val Ala Ile Ala Val Thr Tyr Asn His Asp Gly Ser Tyr Ser Met 
                565                 570                 575     


Gln Ile Glu Asp Lys Thr Phe Gln Val Leu Gly Asn Leu Tyr Ser Glu 
            580                 585                 590         


Gly Asp Cys Thr Tyr Leu Lys Cys Ser Val Asn Gly Val Ala Ser Lys 
        595                 600                 605             


Ala Lys Leu Ile Ile Leu Glu Asn Thr Ile Tyr Leu Phe Ser Lys Glu 
    610                 615                 620                 


Gly Ser Ile Glu Ile Asp Ile Pro Val Pro Lys Tyr Leu Ser Ser Val 
625                 630                 635                 640 


Ser Ser Gln Glu Thr Gln Gly Gly Pro Leu Ala Pro Met Thr Gly Thr 
                645                 650                 655     


Ile Glu Lys Val Phe Val Lys Ala Gly Asp Lys Val Lys Ala Gly Asp 
            660                 665                 670         


Ser Leu Met Val Met Ile Ala Met Lys Met Glu His Thr Ile Lys Ser 
        675                 680                 685             


Pro Lys Asp Gly Thr Val Lys Lys Val Phe Tyr Arg Glu Gly Ala Gln 
    690                 695                 700                 


Ala Asn Arg His Thr Pro Leu Val Glu Phe Glu Glu Glu Glu Ser Asp 
705                 710                 715                 720 


Lys Arg Glu Ser Glu 
                725 

<210>  160
<211>  3341
<212>  DNA
<213>  Homo sapiens

<400>  160
ccgggccccg gcggctgcgc cgagtccccg cccctccctg ctccgtaggg gtaggagggg     60

gccggcggag tttccctccc cgcccagcgg ccctgggcgg gcttttcggc tgcttctcat    120

aagcaggtgg tttcgtttct ccggcacagg taggtttctc tggcaccgat tcggggcctg    180

cccggacttc gccgcacgct gcagaacctc gcccagcgcc caccatgccc cggcagctca    240

gcgcggcggc cgcgctcttc gcgtccctgg ccgtaatttt gcacgatggc agtcaaatga    300

gagcaaaagc atttccagaa accagagatt attctcaacc tactgcagca gcaacagtac    360

aggacataaa aaaacctgtc cagcaaccag ctaagcaagc acctcaccaa actttagcag    420

caagattcat ggatggtcat atcacctttc aaacagcggc cacagtaaaa attccaacaa    480

ctaccccagc gactacaaaa aacactgcaa ccaccagccc aattacctac accctggtca    540

caacccaggc cacacccaac aactcacaca cagctcctcc agttactgaa gttacagtcg    600

gccctagctt agccccttat tcactgccac ccaccatcac cccaccagct catacaactg    660

gaaccagttc atcaaccgtc agccacacaa ctgggaacac cactcaaccc agtaaccaga    720

ccacccttcc agcaacttta tcgatagcac tgcacaaaag cacaaccggt cagaagcctg    780

ttcaacccac ccatgcccca ggaacaacgg cagctgccca caataccacc cgcacagctg    840

cacctgcctc cacggttcct gggcccaccc ttgcacctca gccatcgtca gtcaagactg    900

gaatttatca ggttctaaac ggaagcagac tctgtataaa agcagagatg gggatacagc    960

tgattgttca agacaaggag tcggtttttt cacctcggag atacttcaac atcgacccca   1020

acgcaacgca agcctctggg aactgtggca cccgaaaatc caaccttctg ttgaattttc   1080

agggcggatt tgtgaatctc acatttacca aggatgaaga atcatattat atcagtgaag   1140

tgggagccta tttgaccgtc tcagatccag agacaattta ccaaggaatc aaacatgcgg   1200

tggtgatgtt ccagacagca gtcgggcatt ccttcaagtg cgtgagtgaa cagagcctcc   1260

agttgtcagc ccacctgcag gtgaaaacaa ccgatgtcca acttcaagcc tttgattttg   1320

aagatgacca ctttggaaat gtggatgagt gctcgtctga ctacacaatt gtgcttcctg   1380

tgattggggc catcgtggtt ggtctctgcc ttatgggtat gggtgtctat aaaatccgcc   1440

taaggtgtca atcatctgga taccagagaa tctaattgtt gcccgggggg aatgaaaata   1500

atggaattta gagaactctt tcatcccttc caggatggat gttgggaaat tccctcagag   1560

tgtgggtcct tcaaacaatg taaaccacca tcttctattc aaatgaagtg agtcatgtgt   1620

gatttaagtt caggcagcac atcaatttct aaatactttt tgtttatttt atgaaagata   1680

tagtgagctg tttattttct agtttccttt agaatatttt agccactcaa agtcaacatt   1740

tgagatatgt tgaattaaca taatatatgt aaagtagaat aagccttcaa attataaacc   1800

aagggtcaat tgtaactaat actactgtgt gtgcattgaa gattttattt tacccttgat   1860

cttaacaaag cctttgcttt gttatcaaat ggactttcag tgcttttact atctgtgttt   1920

tatggtttca tgtaacatac atattcctgg tgtagcactt aactcctttt ccactttaaa   1980

tttgtttttg ttttttgaga cggagtttca ctcttgtcac ccaggctgga gtacagtggc   2040

acgatctcgg cttatggcaa cctccgcctc ccgggttcaa gtgattctcc tgcttcagct   2100

tcccgagtag ctgggattac aggcacacac taccacgcct ggctaatttt tgtattttta   2160

ttatagacgg ggtttcacca tgttggccag actggtcttg aactcttgac ctcaggtgat   2220

ccacccacct cagcctccca aagtgctggg attacaggca tgagccattg cgcccggcct   2280

taaatgtttt ttttaatcat caaaaagaac aacatatctc aggttgtcta agtgttttta   2340

tgtaaaacca acaaaaagaa caaatcagct tatatttttt atcttgatga ctcctgctcc   2400

agaatcgcta gactaagaat taggtggcta cagatggtag aactaaacaa taagcaagag   2460

acaataataa tggcccttaa ttattaacaa agtgccagag tctaggctaa gcactttatc   2520

tatatctcat ttcattctca caacttatag gtgaatgagt aaactgagac ttaagggaac   2580

tgaatcactt aaatgtcacc tggctaactg atggcagagc cagagcttga attcatgttg   2640

gtctgacatc aaggtctttg gtcttctccc tacaccaagt tacctacaag aacaatgaca   2700

ccacactctg cctgaaggct cacacctcat accagcatac gctcacctta cagggaaatg   2760

ggtttatcca ggatcatgag acattagggt agatgaaagg agagctttgc agataacaaa   2820

atagcctatc cttaataaat cctccactct ctggaaggag actgaggggc tttgtaaaac   2880

attagtcagt tgctcatttt tatgggattg cttagctggg ctgtaaagat gaaggcatca   2940

aataaactca aagtattttt aaattttttt gataatagag aaacttcgct aaccaactgt   3000

tctttcttga gtgtatagcc ccatcttgtg gtaacttgct gcttctgcac ttcatatcca   3060

tatttcctat tgttcacttt attctgtaga gcagcctgcc aagaatttta tttctgctgt   3120

tttttttgct gctaaagaaa ggaactaagt caggatgtta acagaaaagt ccacataacc   3180

ctagaattct tagtcaagga ataattcaag tcagcctaga gaccatgttg actttcctca   3240

tgtgtttcct tatgactcag taagttggca aggtcctgac tttagtctta ataaaacatt   3300

gaattgtagt aaaggttttt gtaataaaaa cttactttgg a                       3341


<210>  161
<211>  416
<212>  PRT
<213>  Homo sapiens

<400>  161


Met Pro Arg Gln Leu Ser Ala Ala Ala Ala Leu Phe Ala Ser Leu Ala 
1               5                   10                  15      


Val Ile Leu His Asp Gly Ser Gln Met Arg Ala Lys Ala Phe Pro Glu 
            20                  25                  30          


Thr Arg Asp Tyr Ser Gln Pro Thr Ala Ala Ala Thr Val Gln Asp Ile 
        35                  40                  45              


Lys Lys Pro Val Gln Gln Pro Ala Lys Gln Ala Pro His Gln Thr Leu 
    50                  55                  60                  


Ala Ala Arg Phe Met Asp Gly His Ile Thr Phe Gln Thr Ala Ala Thr 
65                  70                  75                  80  


Val Lys Ile Pro Thr Thr Thr Pro Ala Thr Thr Lys Asn Thr Ala Thr 
                85                  90                  95      


Thr Ser Pro Ile Thr Tyr Thr Leu Val Thr Thr Gln Ala Thr Pro Asn 
            100                 105                 110         


Asn Ser His Thr Ala Pro Pro Val Thr Glu Val Thr Val Gly Pro Ser 
        115                 120                 125             


Leu Ala Pro Tyr Ser Leu Pro Pro Thr Ile Thr Pro Pro Ala His Thr 
    130                 135                 140                 


Thr Gly Thr Ser Ser Ser Thr Val Ser His Thr Thr Gly Asn Thr Thr 
145                 150                 155                 160 


Gln Pro Ser Asn Gln Thr Thr Leu Pro Ala Thr Leu Ser Ile Ala Leu 
                165                 170                 175     


His Lys Ser Thr Thr Gly Gln Lys Pro Val Gln Pro Thr His Ala Pro 
            180                 185                 190         


Gly Thr Thr Ala Ala Ala His Asn Thr Thr Arg Thr Ala Ala Pro Ala 
        195                 200                 205             


Ser Thr Val Pro Gly Pro Thr Leu Ala Pro Gln Pro Ser Ser Val Lys 
    210                 215                 220                 


Thr Gly Ile Tyr Gln Val Leu Asn Gly Ser Arg Leu Cys Ile Lys Ala 
225                 230                 235                 240 


Glu Met Gly Ile Gln Leu Ile Val Gln Asp Lys Glu Ser Val Phe Ser 
                245                 250                 255     


Pro Arg Arg Tyr Phe Asn Ile Asp Pro Asn Ala Thr Gln Ala Ser Gly 
            260                 265                 270         


Asn Cys Gly Thr Arg Lys Ser Asn Leu Leu Leu Asn Phe Gln Gly Gly 
        275                 280                 285             


Phe Val Asn Leu Thr Phe Thr Lys Asp Glu Glu Ser Tyr Tyr Ile Ser 
    290                 295                 300                 


Glu Val Gly Ala Tyr Leu Thr Val Ser Asp Pro Glu Thr Ile Tyr Gln 
305                 310                 315                 320 


Gly Ile Lys His Ala Val Val Met Phe Gln Thr Ala Val Gly His Ser 
                325                 330                 335     


Phe Lys Cys Val Ser Glu Gln Ser Leu Gln Leu Ser Ala His Leu Gln 
            340                 345                 350         


Val Lys Thr Thr Asp Val Gln Leu Gln Ala Phe Asp Phe Glu Asp Asp 
        355                 360                 365             


His Phe Gly Asn Val Asp Glu Cys Ser Ser Asp Tyr Thr Ile Val Leu 
    370                 375                 380                 


Pro Val Ile Gly Ala Ile Val Val Gly Leu Cys Leu Met Gly Met Gly 
385                 390                 395                 400 


Val Tyr Lys Ile Arg Leu Arg Cys Gln Ser Ser Gly Tyr Gln Arg Ile 
                405                 410                 415     

<210>  162
<211>  13481
<212>  DNA
<213>  Homo sapiens

<400>  162
gctgccggga cgggtccaag atggacggcc gctcaggttc tgcttttacc tgcggcccag     60

agccccattc attgccccgg tgctgagcgg cgccgcgagt cggcccgagg cctccgggga    120

ctgccgtgcc gggcgggaga ccgccatggc gaccctggaa aagctgatga aggccttcga    180

gtccctcaag tccttccagc agcagcagca gcagcagcag cagcagcagc agcagcagca    240

gcagcagcag cagcagcagc aacagccgcc accgccgccg ccgccgccgc cgcctcctca    300

gcttcctcag ccgccgccgc aggcacagcc gctgctgcct cagccgcagc cgcccccgcc    360

gccgcccccg ccgccacccg gcccggctgt ggctgaggag ccgctgcacc gaccaaagaa    420

agaactttca gctaccaaga aagaccgtgt gaatcattgt ctgacaatat gtgaaaacat    480

agtggcacag tctgtcagaa attctccaga atttcagaaa cttctgggca tcgctatgga    540

actttttctg ctgtgcagtg atgacgcaga gtcagatgtc aggatggtgg ctgacgaatg    600

cctcaacaaa gttatcaaag ctttgatgga ttctaatctt ccaaggttac agctcgagct    660

ctataaggaa attaaaaaga atggtgcccc tcggagtttg cgtgctgccc tgtggaggtt    720

tgctgagctg gctcacctgg ttcggcctca gaaatgcagg ccttacctgg tgaaccttct    780

gccgtgcctg actcgaacaa gcaagagacc cgaagaatca gtccaggaga ccttggctgc    840

agctgttccc aaaattatgg cttcttttgg caattttgca aatgacaatg aaattaaggt    900

tttgttaaag gccttcatag cgaacctgaa gtcaagctcc cccaccattc ggcggacagc    960

ggctggatca gcagtgagca tctgccagca ctcaagaagg acacaatatt tctatagttg   1020

gctactaaat gtgctcttag gcttactcgt tcctgtcgag gatgaacact ccactctgct   1080

gattcttggc gtgctgctca ccctgaggta tttggtgccc ttgctgcagc agcaggtcaa   1140

ggacacaagc ctgaaaggca gcttcggagt gacaaggaaa gaaatggaag tctctccttc   1200

tgcagagcag cttgtccagg tttatgaact gacgttacat catacacagc accaagacca   1260

caatgttgtg accggagccc tggagctgtt gcagcagctc ttcagaacgc ctccacccga   1320

gcttctgcaa accctgaccg cagtcggggg cattgggcag ctcaccgctg ctaaggagga   1380

gtctggtggc cgaagccgta gtgggagtat tgtggaactt atagctggag ggggttcctc   1440

atgcagccct gtcctttcaa gaaaacaaaa aggcaaagtg ctcttaggag aagaagaagc   1500

cttggaggat gactctgaat cgagatcgga tgtcagcagc tctgccttaa cagcctcagt   1560

gaaggatgag atcagtggag agctggctgc ttcttcaggg gtttccactc cagggtcagc   1620

aggtcatgac atcatcacag aacagccacg gtcacagcac acactgcagg cggactcagt   1680

ggatctggcc agctgtgact tgacaagctc tgccactgat ggggatgagg aggatatctt   1740

gagccacagc tccagccagg tcagcgccgt cccatctgac cctgccatgg acctgaatga   1800

tgggacccag gcctcgtcgc ccatcagcga cagctcccag accaccaccg aagggcctga   1860

ttcagctgtt accccttcag acagttctga aattgtgtta gacggtaccg acaaccagta   1920

tttgggcctg cagattggac agccccagga tgaagatgag gaagccacag gtattcttcc   1980

tgatgaagcc tcggaggcct tcaggaactc ttccatggcc cttcaacagg cacatttatt   2040

gaaaaacatg agtcactgca ggcagccttc tgacagcagt gttgataaat ttgtgttgag   2100

agatgaagct actgaaccgg gtgatcaaga aaacaagcct tgccgcatca aaggtgacat   2160

tggacagtcc actgatgatg actctgcacc tcttgtccat tgtgtccgcc ttttatctgc   2220

ttcgtttttg ctaacagggg gaaaaaatgt gctggttccg gacagggatg tgagggtcag   2280

cgtgaaggcc ctggccctca gctgtgtggg agcagctgtg gccctccacc cggaatcttt   2340

cttcagcaaa ctctataaag ttcctcttga caccacggaa taccctgagg aacagtatgt   2400

ctcagacatc ttgaactaca tcgatcatgg agacccacag gttcgaggag ccactgccat   2460

tctctgtggg accctcatct gctccatcct cagcaggtcc cgcttccacg tgggagattg   2520

gatgggcacc attagaaccc tcacaggaaa tacattttct ttggcggatt gcattccttt   2580

gctgcggaaa acactgaagg atgagtcttc tgttacttgc aagttagctt gtacagctgt   2640

gaggaactgt gtcatgagtc tctgcagcag cagctacagt gagttaggac tgcagctgat   2700

catcgatgtg ctgactctga ggaacagttc ctattggctg gtgaggacag agcttctgga   2760

aacccttgca gagattgact tcaggctggt gagctttttg gaggcaaaag cagaaaactt   2820

acacagaggg gctcatcatt atacagggct tttaaaactg caagaacgag tgctcaataa   2880

tgttgtcatc catttgcttg gagatgaaga ccccagggtg cgacatgttg ccgcagcatc   2940

actaattagg cttgtcccaa agctgtttta taaatgtgac caaggacaag ctgatccagt   3000

agtggccgtg gcaagagatc aaagcagtgt ttacctgaaa cttctcatgc atgagacgca   3060

gcctccatct catttctccg tcagcacaat aaccagaata tatagaggct ataacctact   3120

accaagcata acagacgtca ctatggaaaa taacctttca agagttattg cagcagtttc   3180

tcatgaacta atcacatcaa ccaccagagc actcacattt ggatgctgtg aagctttgtg   3240

tcttctttcc actgccttcc cagtttgcat ttggagttta ggttggcact gtggagtgcc   3300

tccactgagt gcctcagatg agtctaggaa gagctgtacc gttgggatgg ccacaatgat   3360

tctgaccctg ctctcgtcag cttggttccc attggatctc tcagcccatc aagatgcttt   3420

gattttggcc ggaaacttgc ttgcagccag tgctcccaaa tctctgagaa gttcatgggc   3480

ctctgaagaa gaagccaacc cagcagccac caagcaagag gaggtctggc cagccctggg   3540

ggaccgggcc ctggtgccca tggtggagca gctcttctct cacctgctga aggtgattaa   3600

catttgtgcc cacgtcctgg atgacgtggc tcctggaccc gcaataaagg cagccttgcc   3660

ttctctaaca aacccccctt ctctaagtcc catccgacga aaggggaagg agaaagaacc   3720

aggagaacaa gcatctgtac cgttgagtcc caagaaaggc agtgaggcca gtgcagcttc   3780

tagacaatct gatacctcag gtcctgttac aacaagtaaa tcctcatcac tggggagttt   3840

ctatcatctt ccttcatacc tcaaactgca tgatgtcctg aaagctacac acgctaacta   3900

caaggtcacg ctggatcttc agaacagcac ggaaaagttt ggagggtttc tccgctcagc   3960

cttggatgtt ctttctcaga tactagagct ggccacactg caggacattg ggaagtgtgt   4020

tgaagagatc ctaggatacc tgaaatcctg ctttagtcga gaaccaatga tggcaactgt   4080

ttgtgttcaa caattgttga agactctctt tggcacaaac ttggcctccc agtttgatgg   4140

cttatcttcc aaccccagca agtcacaagg ccgagcacag cgccttggct cctccagtgt   4200

gaggccaggc ttgtaccact actgcttcat ggccccgtac acccacttca cccaggccct   4260

cgctgacgcc agcctgagga acatggtgca ggcggagcag gagaacgaca cctcgggatg   4320

gtttgatgtc ctccagaaag tgtctaccca gttgaagaca aacctcacga gtgtcacaaa   4380

gaaccgtgca gataagaatg ctattcataa tcacattcgt ttgtttgaac ctcttgttat   4440

aaaagcttta aaacagtaca cgactacaac atgtgtgcag ttacagaagc aggttttaga   4500

tttgctggcg cagctggttc agttacgggt taattactgt cttctggatt cagatcaggt   4560

gtttattggc tttgtattga aacagtttga atacattgaa gtgggccagt tcagggaatc   4620

agaggcaatc attccaaaca tctttttctt cttggtatta ctatcttatg aacgctatca   4680

ttcaaaacag atcattggaa ttcctaaaat cattcagctc tgtgatggca tcatggccag   4740

tggaaggaag gctgtgacac atgccatacc ggctctgcag cccatagtcc acgacctctt   4800

tgtattaaga ggaacaaata aagctgatgc aggaaaagag cttgaaaccc aaaaagaggt   4860

ggtggtgtca atgttactga gactcatcca gtaccatcag gtgttggaga tgttcattct   4920

tgtcctgcag cagtgccaca aggagaatga agacaagtgg aagcgactgt ctcgacagat   4980

agctgacatc atcctcccaa tgttagccaa acagcagatg cacattgact ctcatgaagc   5040

ccttggagtg ttaaatacat tatttgagat tttggcccct tcctccctcc gtccggtaga   5100

catgctttta cggagtatgt tcgtcactcc aaacacaatg gcgtccgtga gcactgttca   5160

actgtggata tcgggaattc tggccatttt gagggttctg atttcccagt caactgaaga   5220

tattgttctt tctcgtattc aggagctctc cttctctccg tatttaatct cctgtacagt   5280

aattaatagg ttaagagatg gggacagtac ttcaacgcta gaagaacaca gtgaagggaa   5340

acaaataaag aatttgccag aagaaacatt ttcaaggttt ctattacaac tggttggtat   5400

tcttttagaa gacattgtta caaaacagct gaaggtggaa atgagtgagc agcaacatac   5460

tttctattgc caggaactag gcacactgct aatgtgtctg atccacatct tcaagtctgg   5520

aatgttccgg agaatcacag cagctgccac taggctgttc cgcagtgatg gctgtggcgg   5580

cagtttctac accctggaca gcttgaactt gcgggctcgt tccatgatca ccacccaccc   5640

ggccctggtg ctgctctggt gtcagatact gctgcttgtc aaccacaccg actaccgctg   5700

gtgggcagaa gtgcagcaga ccccgaaaag acacagtctg tccagcacaa agttacttag   5760

tccccagatg tctggagaag aggaggattc tgacttggca gccaaacttg gaatgtgcaa   5820

tagagaaata gtacgaagag gggctctcat tctcttctgt gattatgtct gtcagaacct   5880

ccatgactcc gagcacttaa cgtggctcat tgtaaatcac attcaagatc tgatcagcct   5940

ttcccacgag cctccagtac aggacttcat cagtgccgtt catcggaact ctgctgccag   6000

cggcctgttc atccaggcaa ttcagtctcg ttgtgaaaac ctttcaactc caaccatgct   6060

gaagaaaact cttcagtgct tggaggggat ccatctcagc cagtcgggag ctgtgctcac   6120

gctgtatgtg gacaggcttc tgtgcacccc tttccgtgtg ctggctcgca tggtcgacat   6180

ccttgcttgt cgccgggtag aaatgcttct ggctgcaaat ttacagagca gcatggccca   6240

gttgccaatg gaagaactca acagaatcca ggaatacctt cagagcagcg ggctcgctca   6300

gagacaccaa aggctctatt ccctgctgga caggtttcgt ctctccacca tgcaagactc   6360

acttagtccc tctcctccag tctcttccca cccgctggac ggggatgggc acgtgtcact   6420

ggaaacagtg agtccggaca aagactggta cgttcatctt gtcaaatccc agtgttggac   6480

caggtcagat tctgcactgc tggaaggtgc agagctggtg aatcggattc ctgctgaaga   6540

tatgaatgcc ttcatgatga actcggagtt caacctaagc ctgctagctc catgcttaag   6600

cctagggatg agtgaaattt ctggtggcca gaagagtgcc ctttttgaag cagcccgtga   6660

ggtgactctg gcccgtgtga gcggcaccgt gcagcagctc cctgctgtcc atcatgtctt   6720

ccagcccgag ctgcctgcag agccggcggc ctactggagc aagttgaatg atctgtttgg   6780

ggatgctgca ctgtatcagt ccctgcccac tctggcccgg gccctggcac agtacctggt   6840

ggtggtctcc aaactgccca gtcatttgca ccttcctcct gagaaagaga aggacattgt   6900

gaaattcgtg gtggcaaccc ttgaggccct gtcctggcat ttgatccatg agcagatccc   6960

gctgagtctg gatctccagg cagggctgga ctgctgctgc ctggccctgc agctgcctgg   7020

cctctggagc gtggtctcct ccacagagtt tgtgacccac gcctgctccc tcatctactg   7080

tgtgcacttc atcctggagg ccgttgcagt gcagcctgga gagcagcttc ttagtccaga   7140

aagaaggaca aataccccaa aagccatcag cgaggaggag gaggaagtag atccaaacac   7200

acagaatcct aagtatatca ctgcagcctg tgagatggtg gcagaaatgg tggagtctct   7260

gcagtcggtg ttggccttgg gtcataaaag gaatagcggc gtgccggcgt ttctcacgcc   7320

attgctaagg aacatcatca tcagcctggc ccgcctgccc cttgtcaaca gctacacacg   7380

tgtgccccca ctggtgtgga agcttggatg gtcacccaaa ccgggagggg attttggcac   7440

agcattccct gagatccccg tggagttcct ccaggaaaag gaagtcttta aggagttcat   7500

ctaccgcatc aacacactag gctggaccag tcgtactcag tttgaagaaa cttgggccac   7560

cctccttggt gtcctggtga cgcagcccct cgtgatggag caggaggaga gcccaccaga   7620

agaagacaca gagaggaccc agatcaacgt cctggccgtg caggccatca cctcactggt   7680

gctcagtgca atgactgtgc ctgtggccgg caacccagct gtaagctgct tggagcagca   7740

gccccggaac aagcctctga aagctctcga caccaggttt gggaggaagc tgagcattat   7800

cagagggatt gtggagcaag agattcaagc aatggtttca aagagagaga atattgccac   7860

ccatcattta tatcaggcat gggatcctgt cccttctctg tctccggcta ctacaggtgc   7920

cctcatcagc cacgagaagc tgctgctaca gatcaacccc gagcgggagc tggggagcat   7980

gagctacaaa ctcggccagg tgtccataca ctccgtgtgg ctggggaaca gcatcacacc   8040

cctgagggag gaggaatggg acgaggaaga ggaggaggag gccgacgccc ctgcaccttc   8100

gtcaccaccc acgtctccag tcaactccag gaaacaccgg gctggagttg acatccactc   8160

ctgttcgcag tttttgcttg agttgtacag ccgctggatc ctgccgtcca gctcagccag   8220

gaggaccccg gccatcctga tcagtgaggt ggtcagatcc cttctagtgg tctcagactt   8280

gttcaccgag cgcaaccagt ttgagctgat gtatgtgacg ctgacagaac tgcgaagggt   8340

gcacccttca gaagacgaga tcctcgctca gtacctggtg cctgccacct gcaaggcagc   8400

tgccgtcctt gggatggaca aggccgtggc ggagcctgtc agccgcctgc tggagagcac   8460

gctcaggagc agccacctgc ccagcagggt tggagccctg cacggcgtcc tctatgtgct   8520

ggagtgcgac ctgctggacg acactgccaa gcagctcatc ccggtcatca gcgactatct   8580

cctctccaac ctgaaaggga tcgcccactg cgtgaacatt cacagccagc agcacgtact   8640

ggtcatgtgt gccactgcgt tttacctcat tgagaactat cctctggacg tagggccgga   8700

attttcagca tcaataatac agatgtgtgg ggtgatgctg tctggaagtg aggagtccac   8760

cccctccatc atttaccact gtgccctcag aggcctggag cgcctcctgc tctctgagca   8820

gctctcccgc ctggatgcag aatcgctggt caagctgagt gtggacagag tgaacgtgca   8880

cagcccgcac cgggccatgg cggctctggg cctgatgctc acctgcatgt acacaggaaa   8940

ggagaaagtc agtccgggta gaacttcaga ccctaatcct gcagcccccg acagcgagtc   9000

agtgattgtt gctatggagc gggtatctgt tctttttgat aggatcagga aaggctttcc   9060

ttgtgaagcc agagtggtgg ccaggatcct gccccagttt ctagacgact tcttcccacc   9120

ccaggacatc atgaacaaag tcatcggaga gtttctgtcc aaccagcagc cataccccca   9180

gttcatggcc accgtggtgt ataaggtgtt tcagactctg cacagcaccg ggcagtcgtc   9240

catggtccgg gactgggtca tgctgtccct ctccaacttc acgcagaggg ccccggtcgc   9300

catggccacg tggagcctct cctgcttctt tgtcagcgcg tccaccagcc cgtgggtcgc   9360

ggcgatcctc ccacatgtca tcagcaggat gggcaagctg gagcaggtgg acgtgaacct   9420

tttctgcctg gtcgccacag acttctacag acaccagata gaggaggagc tcgaccgcag   9480

ggccttccag tctgtgcttg aggtggttgc agccccagga agcccatatc accggctgct   9540

gacttgttta cgaaatgtcc acaaggtcac cacctgctga gcgccatggt gggagagact   9600

gtgaggcggc agctggggcc ggagcctttg gaagtctgcg cccttgtgcc ctgcctccac   9660

cgagccagct tggtccctat gggcttccgc acatgccgcg ggcggccagg caacgtgcgt   9720

gtctctgcca tgtggcagaa gtgctctttg tggcagtggc caggcaggga gtgtctgcag   9780

tcctggtggg gctgagcctg aggccttcca gaaagcagga gcagctgtgc tgcaccccat   9840

gtgggtgacc aggtcctttc tcctgatagt cacctgctgg ttgttgccag gttgcagctg   9900

ctcttgcatc tgggccagaa gtcctccctc ctgcaggctg gctgttggcc cctctgctgt   9960

cctgcagtag aaggtgccgt gagcaggctt tgggaacact ggcctgggtc tccctggtgg  10020

ggtgtgcatg ccacgccccg tgtctggatg cacagatgcc atggcctgtg ctgggccagt  10080

ggctgggggt gctagacacc cggcaccatt ctcccttctc tcttttcttc tcaggattta  10140

aaatttaatt atatcagtaa agagattaat tttaacgtaa ctctttctat gcccgtgtaa  10200

agtatgtgaa tcgcaaggcc tgtgctgcat gcgacagcgt ccggggtggt ggacagggcc  10260

cccggccacg ctccctctcc tgtagccact ggcatagccc tcctgagcac ccgctgacat  10320

ttccgttgta catgttcctg tttatgcatt cacaaggtga ctgggatgta gagaggcgtt  10380

agtgggcagg tggccacagc aggactgagg acaggccccc attatcctag gggtgcgctc  10440

acctgcagcc cctcctcctc gggcacagac gactgtcgtt ctccacccac cagtcaggga  10500

cagcagcctc cctgtcactc agctgagaag gccagccctc cctggctgtg agcagcctcc  10560

actgtgtcca gagacatggg cctcccactc ctgttccttg ctagccctgg ggtggcgtct  10620

gcctaggagc tggctggcag gtgttgggac ctgctgctcc atggatgcat gccctaagag  10680

tgtcactgag ctgtgttttg tctgagcctc tctcggtcaa cagcaaagct tggtgtcttg  10740

gcactgttag tgacagagcc cagcatccct tctgcccccg ttccagctga catcttgcac  10800

ggtgacccct tttagtcagg agagtgcaga tctgtgctca tcggagactg ccccacggcc  10860

ctgtcagagc cgccactcct atccccaggc caggtccctg gaccagcctc ctgtttgcag  10920

gcccagagga gccaagtcat taaaatggaa gtggattctg gatggccggg ctgctgctga  10980

tgtaggagct ggatttggga gctctgcttg ccgactggct gtgagacgag gcaggggctc  11040

tgcttcctca gccctagagg cgagccaggc aaggttggcg actgtcatgt ggcttggttt  11100

ggtcatgccc gtcgatgttt tgggtattga atgtggtaag tggaggaaat gttggaactc  11160

tgtgcaggtg ctgccttgag acccccaagc ttccacctgt ccctctccta tgtggcagct  11220

ggggagcagc tgagatgtgg acttgtatgc tgcccacata cgtgaggggg agctgaaagg  11280

gagcccctcc tctgagcagc ctctgccagg cctgtatgag gcttttccca ccagctccca  11340

acagaggcct cccccagcca ggaccacctc gtcctcgtgg cggggcagca ggagcggtag  11400

aaaggggtcc gatgtttgag gaggccctta agggaagcta ctgaattata acacgtaaga  11460

aaatcaccat tccgtattgg ttgggggctc ctgtttctca tcctagcttt ttcctggaaa  11520

gcccgctaga aggtttggga acgaggggaa agttctcaga actgttggct gctccccacc  11580

cgcctcccgc ctcccccgca ggttatgtca gcagctctga gacagcagta tcacaggcca  11640

gatgttgttc ctggctagat gtttacattt gtaagaaata acactgtgaa tgtaaaacag  11700

agccattccc ttggaatgca tatcgctggg ctcaacatag agtttgtctt cctcttgttt  11760

acgacgtgat ctaaaccagt ccttagcaag gggctcagaa caccccgctc tggcagtagg  11820

tgtcccccac ccccaaagac ctgcctgtgt gctccggaga tgaatatgag ctcattagta  11880

aaaatgactt cacccacgca tatacataaa gtatccatgc atgtgcatat agacacatct  11940

ataattttac acacacacct ctcaagacgg agatgcatgg cctctaagag tgcccgtgtc  12000

ggttcttcct ggaagttgac tttccttaga cccgccaggt caagttagcc gcgtgacgga  12060

catccaggcg tgggacgtgg tcagggcagg gctcattcat tgcccactag gatcccactg  12120

gcgaagatgg tctccatatc agctctctgc agaagggagg aagactttat catgttccta  12180

aaaatctgtg gcaagcaccc atcgtattat ccaaattttg ttgcaaatgt gattaatttg  12240

gttgtcaagt tttgggggtg ggctgtgggg agattgcttt tgttttcctg ctggtaatat  12300

cgggaaagat tttaatgaaa ccagggtaga attgtttggc aatgcactga agcgtgtttc  12360

tttcccaaaa tgtgcctccc ttccgctgcg ggcccagctg agtctatgta ggtgatgttt  12420

ccagctgcca agtgctcttt gttactgtcc accctcattt ctgccagcgc atgtgtcctt  12480

tcaaggggaa aatgtgaagc tgaaccccct ccagacaccc agaatgtagc atctgagaag  12540

gccctgtgcc ctaaaggaca cccctcgccc ccatcttcat ggagggggtc atttcagagc  12600

cctcggagcc aatgaacagc tcctcctctt ggagctgaga tgagccccac gtggagctcg  12660

ggacggatag tagacagcaa taactcggtg tgtggccgcc tggcaggtgg aacttcctcc  12720

cgttgcgggg tggagtgagg ttagttctgt gtgtctggtg ggtggagtca ggcttctctt  12780

gctacctgtg agcatccttc ccagcagaca tcctcatcgg gctttgtccc tcccccgctt  12840

cctccctctg cggggaggac ccgggaccac agctgctggc cagggtagac ttggagctgt  12900

cctccagagg ggtcacgtgt aggagtgaga agaaggaaga tcttgagagc tgctgaggga  12960

ccttggagag ctcaggatgg ctcagacgag gacactcgct tgccgggcct gggcctcctg  13020

ggaaggaggg agctgctcag aatgccgcat gacaactgaa ggcaacctgg aaggttcagg  13080

ggccgctctt cccccatgtg cctgtcacgc tctggtgcag tcaaaggaac gccttcccct  13140

cagttgtttc taagagcaga gtctcccgct gcaatctggg tggtaactgc cagccttgga  13200

ggatcgtggc caacgtggac ctgcctacgg agggtgggct ctgacccaag tggggcctcc  13260

ttgtccaggt ctcactgctt tgcaccgtgg tcagagggac tgtcagctga gcttgagctc  13320

ccctggagcc agcagggctg tgatgggcga gtcccggagc cccacccaga cctgaatgct  13380

tctgagagca aagggaagga ctgacgagag atgtatattt aattttttaa ctgctgcaaa  13440

cattgtacat ccaaattaaa ggaaaaaaat ggaaaccatc a                      13481


<210>  163
<211>  3144
<212>  PRT
<213>  Homo sapiens

<400>  163


Met Ala Thr Leu Glu Lys Leu Met Lys Ala Phe Glu Ser Leu Lys Ser 
1               5                   10                  15      


Phe Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
            20                  25                  30          


Gln Gln Gln Gln Gln Gln Gln Gln Pro Pro Pro Pro Pro Pro Pro Pro 
        35                  40                  45              


Pro Pro Pro Gln Leu Pro Gln Pro Pro Pro Gln Ala Gln Pro Leu Leu 
    50                  55                  60                  


Pro Gln Pro Gln Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Gly Pro 
65                  70                  75                  80  


Ala Val Ala Glu Glu Pro Leu His Arg Pro Lys Lys Glu Leu Ser Ala 
                85                  90                  95      


Thr Lys Lys Asp Arg Val Asn His Cys Leu Thr Ile Cys Glu Asn Ile 
            100                 105                 110         


Val Ala Gln Ser Val Arg Asn Ser Pro Glu Phe Gln Lys Leu Leu Gly 
        115                 120                 125             


Ile Ala Met Glu Leu Phe Leu Leu Cys Ser Asp Asp Ala Glu Ser Asp 
    130                 135                 140                 


Val Arg Met Val Ala Asp Glu Cys Leu Asn Lys Val Ile Lys Ala Leu 
145                 150                 155                 160 


Met Asp Ser Asn Leu Pro Arg Leu Gln Leu Glu Leu Tyr Lys Glu Ile 
                165                 170                 175     


Lys Lys Asn Gly Ala Pro Arg Ser Leu Arg Ala Ala Leu Trp Arg Phe 
            180                 185                 190         


Ala Glu Leu Ala His Leu Val Arg Pro Gln Lys Cys Arg Pro Tyr Leu 
        195                 200                 205             


Val Asn Leu Leu Pro Cys Leu Thr Arg Thr Ser Lys Arg Pro Glu Glu 
    210                 215                 220                 


Ser Val Gln Glu Thr Leu Ala Ala Ala Val Pro Lys Ile Met Ala Ser 
225                 230                 235                 240 


Phe Gly Asn Phe Ala Asn Asp Asn Glu Ile Lys Val Leu Leu Lys Ala 
                245                 250                 255     


Phe Ile Ala Asn Leu Lys Ser Ser Ser Pro Thr Ile Arg Arg Thr Ala 
            260                 265                 270         


Ala Gly Ser Ala Val Ser Ile Cys Gln His Ser Arg Arg Thr Gln Tyr 
        275                 280                 285             


Phe Tyr Ser Trp Leu Leu Asn Val Leu Leu Gly Leu Leu Val Pro Val 
    290                 295                 300                 


Glu Asp Glu His Ser Thr Leu Leu Ile Leu Gly Val Leu Leu Thr Leu 
305                 310                 315                 320 


Arg Tyr Leu Val Pro Leu Leu Gln Gln Gln Val Lys Asp Thr Ser Leu 
                325                 330                 335     


Lys Gly Ser Phe Gly Val Thr Arg Lys Glu Met Glu Val Ser Pro Ser 
            340                 345                 350         


Ala Glu Gln Leu Val Gln Val Tyr Glu Leu Thr Leu His His Thr Gln 
        355                 360                 365             


His Gln Asp His Asn Val Val Thr Gly Ala Leu Glu Leu Leu Gln Gln 
    370                 375                 380                 


Leu Phe Arg Thr Pro Pro Pro Glu Leu Leu Gln Thr Leu Thr Ala Val 
385                 390                 395                 400 


Gly Gly Ile Gly Gln Leu Thr Ala Ala Lys Glu Glu Ser Gly Gly Arg 
                405                 410                 415     


Ser Arg Ser Gly Ser Ile Val Glu Leu Ile Ala Gly Gly Gly Ser Ser 
            420                 425                 430         


Cys Ser Pro Val Leu Ser Arg Lys Gln Lys Gly Lys Val Leu Leu Gly 
        435                 440                 445             


Glu Glu Glu Ala Leu Glu Asp Asp Ser Glu Ser Arg Ser Asp Val Ser 
    450                 455                 460                 


Ser Ser Ala Leu Thr Ala Ser Val Lys Asp Glu Ile Ser Gly Glu Leu 
465                 470                 475                 480 


Ala Ala Ser Ser Gly Val Ser Thr Pro Gly Ser Ala Gly His Asp Ile 
                485                 490                 495     


Ile Thr Glu Gln Pro Arg Ser Gln His Thr Leu Gln Ala Asp Ser Val 
            500                 505                 510         


Asp Leu Ala Ser Cys Asp Leu Thr Ser Ser Ala Thr Asp Gly Asp Glu 
        515                 520                 525             


Glu Asp Ile Leu Ser His Ser Ser Ser Gln Val Ser Ala Val Pro Ser 
    530                 535                 540                 


Asp Pro Ala Met Asp Leu Asn Asp Gly Thr Gln Ala Ser Ser Pro Ile 
545                 550                 555                 560 


Ser Asp Ser Ser Gln Thr Thr Thr Glu Gly Pro Asp Ser Ala Val Thr 
                565                 570                 575     


Pro Ser Asp Ser Ser Glu Ile Val Leu Asp Gly Thr Asp Asn Gln Tyr 
            580                 585                 590         


Leu Gly Leu Gln Ile Gly Gln Pro Gln Asp Glu Asp Glu Glu Ala Thr 
        595                 600                 605             


Gly Ile Leu Pro Asp Glu Ala Ser Glu Ala Phe Arg Asn Ser Ser Met 
    610                 615                 620                 


Ala Leu Gln Gln Ala His Leu Leu Lys Asn Met Ser His Cys Arg Gln 
625                 630                 635                 640 


Pro Ser Asp Ser Ser Val Asp Lys Phe Val Leu Arg Asp Glu Ala Thr 
                645                 650                 655     


Glu Pro Gly Asp Gln Glu Asn Lys Pro Cys Arg Ile Lys Gly Asp Ile 
            660                 665                 670         


Gly Gln Ser Thr Asp Asp Asp Ser Ala Pro Leu Val His Cys Val Arg 
        675                 680                 685             


Leu Leu Ser Ala Ser Phe Leu Leu Thr Gly Gly Lys Asn Val Leu Val 
    690                 695                 700                 


Pro Asp Arg Asp Val Arg Val Ser Val Lys Ala Leu Ala Leu Ser Cys 
705                 710                 715                 720 


Val Gly Ala Ala Val Ala Leu His Pro Glu Ser Phe Phe Ser Lys Leu 
                725                 730                 735     


Tyr Lys Val Pro Leu Asp Thr Thr Glu Tyr Pro Glu Glu Gln Tyr Val 
            740                 745                 750         


Ser Asp Ile Leu Asn Tyr Ile Asp His Gly Asp Pro Gln Val Arg Gly 
        755                 760                 765             


Ala Thr Ala Ile Leu Cys Gly Thr Leu Ile Cys Ser Ile Leu Ser Arg 
    770                 775                 780                 


Ser Arg Phe His Val Gly Asp Trp Met Gly Thr Ile Arg Thr Leu Thr 
785                 790                 795                 800 


Gly Asn Thr Phe Ser Leu Ala Asp Cys Ile Pro Leu Leu Arg Lys Thr 
                805                 810                 815     


Leu Lys Asp Glu Ser Ser Val Thr Cys Lys Leu Ala Cys Thr Ala Val 
            820                 825                 830         


Arg Asn Cys Val Met Ser Leu Cys Ser Ser Ser Tyr Ser Glu Leu Gly 
        835                 840                 845             


Leu Gln Leu Ile Ile Asp Val Leu Thr Leu Arg Asn Ser Ser Tyr Trp 
    850                 855                 860                 


Leu Val Arg Thr Glu Leu Leu Glu Thr Leu Ala Glu Ile Asp Phe Arg 
865                 870                 875                 880 


Leu Val Ser Phe Leu Glu Ala Lys Ala Glu Asn Leu His Arg Gly Ala 
                885                 890                 895     


His His Tyr Thr Gly Leu Leu Lys Leu Gln Glu Arg Val Leu Asn Asn 
            900                 905                 910         


Val Val Ile His Leu Leu Gly Asp Glu Asp Pro Arg Val Arg His Val 
        915                 920                 925             


Ala Ala Ala Ser Leu Ile Arg Leu Val Pro Lys Leu Phe Tyr Lys Cys 
    930                 935                 940                 


Asp Gln Gly Gln Ala Asp Pro Val Val Ala Val Ala Arg Asp Gln Ser 
945                 950                 955                 960 


Ser Val Tyr Leu Lys Leu Leu Met His Glu Thr Gln Pro Pro Ser His 
                965                 970                 975     


Phe Ser Val Ser Thr Ile Thr Arg Ile Tyr Arg Gly Tyr Asn Leu Leu 
            980                 985                 990         


Pro Ser Ile Thr Asp Val Thr Met  Glu Asn Asn Leu Ser  Arg Val Ile 
        995                 1000                 1005             


Ala Ala  Val Ser His Glu Leu  Ile Thr Ser Thr Thr  Arg Ala Leu 
    1010                 1015                 1020             


Thr Phe  Gly Cys Cys Glu Ala  Leu Cys Leu Leu Ser  Thr Ala Phe 
    1025                 1030                 1035             


Pro Val  Cys Ile Trp Ser Leu  Gly Trp His Cys Gly  Val Pro Pro 
    1040                 1045                 1050             


Leu Ser  Ala Ser Asp Glu Ser  Arg Lys Ser Cys Thr  Val Gly Met 
    1055                 1060                 1065             


Ala Thr  Met Ile Leu Thr Leu  Leu Ser Ser Ala Trp  Phe Pro Leu 
    1070                 1075                 1080             


Asp Leu  Ser Ala His Gln Asp  Ala Leu Ile Leu Ala  Gly Asn Leu 
    1085                 1090                 1095             


Leu Ala  Ala Ser Ala Pro Lys  Ser Leu Arg Ser Ser  Trp Ala Ser 
    1100                 1105                 1110             


Glu Glu  Glu Ala Asn Pro Ala  Ala Thr Lys Gln Glu  Glu Val Trp 
    1115                 1120                 1125             


Pro Ala  Leu Gly Asp Arg Ala  Leu Val Pro Met Val  Glu Gln Leu 
    1130                 1135                 1140             


Phe Ser  His Leu Leu Lys Val  Ile Asn Ile Cys Ala  His Val Leu 
    1145                 1150                 1155             


Asp Asp  Val Ala Pro Gly Pro  Ala Ile Lys Ala Ala  Leu Pro Ser 
    1160                 1165                 1170             


Leu Thr  Asn Pro Pro Ser Leu  Ser Pro Ile Arg Arg  Lys Gly Lys 
    1175                 1180                 1185             


Glu Lys  Glu Pro Gly Glu Gln  Ala Ser Val Pro Leu  Ser Pro Lys 
    1190                 1195                 1200             


Lys Gly  Ser Glu Ala Ser Ala  Ala Ser Arg Gln Ser  Asp Thr Ser 
    1205                 1210                 1215             


Gly Pro  Val Thr Thr Ser Lys  Ser Ser Ser Leu Gly  Ser Phe Tyr 
    1220                 1225                 1230             


His Leu  Pro Ser Tyr Leu Lys  Leu His Asp Val Leu  Lys Ala Thr 
    1235                 1240                 1245             


His Ala  Asn Tyr Lys Val Thr  Leu Asp Leu Gln Asn  Ser Thr Glu 
    1250                 1255                 1260             


Lys Phe  Gly Gly Phe Leu Arg  Ser Ala Leu Asp Val  Leu Ser Gln 
    1265                 1270                 1275             


Ile Leu  Glu Leu Ala Thr Leu  Gln Asp Ile Gly Lys  Cys Val Glu 
    1280                 1285                 1290             


Glu Ile  Leu Gly Tyr Leu Lys  Ser Cys Phe Ser Arg  Glu Pro Met 
    1295                 1300                 1305             


Met Ala  Thr Val Cys Val Gln  Gln Leu Leu Lys Thr  Leu Phe Gly 
    1310                 1315                 1320             


Thr Asn  Leu Ala Ser Gln Phe  Asp Gly Leu Ser Ser  Asn Pro Ser 
    1325                 1330                 1335             


Lys Ser  Gln Gly Arg Ala Gln  Arg Leu Gly Ser Ser  Ser Val Arg 
    1340                 1345                 1350             


Pro Gly  Leu Tyr His Tyr Cys  Phe Met Ala Pro Tyr  Thr His Phe 
    1355                 1360                 1365             


Thr Gln  Ala Leu Ala Asp Ala  Ser Leu Arg Asn Met  Val Gln Ala 
    1370                 1375                 1380             


Glu Gln  Glu Asn Asp Thr Ser  Gly Trp Phe Asp Val  Leu Gln Lys 
    1385                 1390                 1395             


Val Ser  Thr Gln Leu Lys Thr  Asn Leu Thr Ser Val  Thr Lys Asn 
    1400                 1405                 1410             


Arg Ala  Asp Lys Asn Ala Ile  His Asn His Ile Arg  Leu Phe Glu 
    1415                 1420                 1425             


Pro Leu  Val Ile Lys Ala Leu  Lys Gln Tyr Thr Thr  Thr Thr Cys 
    1430                 1435                 1440             


Val Gln  Leu Gln Lys Gln Val  Leu Asp Leu Leu Ala  Gln Leu Val 
    1445                 1450                 1455             


Gln Leu  Arg Val Asn Tyr Cys  Leu Leu Asp Ser Asp  Gln Val Phe 
    1460                 1465                 1470             


Ile Gly  Phe Val Leu Lys Gln  Phe Glu Tyr Ile Glu  Val Gly Gln 
    1475                 1480                 1485             


Phe Arg  Glu Ser Glu Ala Ile  Ile Pro Asn Ile Phe  Phe Phe Leu 
    1490                 1495                 1500             


Val Leu  Leu Ser Tyr Glu Arg  Tyr His Ser Lys Gln  Ile Ile Gly 
    1505                 1510                 1515             


Ile Pro  Lys Ile Ile Gln Leu  Cys Asp Gly Ile Met  Ala Ser Gly 
    1520                 1525                 1530             


Arg Lys  Ala Val Thr His Ala  Ile Pro Ala Leu Gln  Pro Ile Val 
    1535                 1540                 1545             


His Asp  Leu Phe Val Leu Arg  Gly Thr Asn Lys Ala  Asp Ala Gly 
    1550                 1555                 1560             


Lys Glu  Leu Glu Thr Gln Lys  Glu Val Val Val Ser  Met Leu Leu 
    1565                 1570                 1575             


Arg Leu  Ile Gln Tyr His Gln  Val Leu Glu Met Phe  Ile Leu Val 
    1580                 1585                 1590             


Leu Gln  Gln Cys His Lys Glu  Asn Glu Asp Lys Trp  Lys Arg Leu 
    1595                 1600                 1605             


Ser Arg  Gln Ile Ala Asp Ile  Ile Leu Pro Met Leu  Ala Lys Gln 
    1610                 1615                 1620             


Gln Met  His Ile Asp Ser His  Glu Ala Leu Gly Val  Leu Asn Thr 
    1625                 1630                 1635             


Leu Phe  Glu Ile Leu Ala Pro  Ser Ser Leu Arg Pro  Val Asp Met 
    1640                 1645                 1650             


Leu Leu  Arg Ser Met Phe Val  Thr Pro Asn Thr Met  Ala Ser Val 
    1655                 1660                 1665             


Ser Thr  Val Gln Leu Trp Ile  Ser Gly Ile Leu Ala  Ile Leu Arg 
    1670                 1675                 1680             


Val Leu  Ile Ser Gln Ser Thr  Glu Asp Ile Val Leu  Ser Arg Ile 
    1685                 1690                 1695             


Gln Glu  Leu Ser Phe Ser Pro  Tyr Leu Ile Ser Cys  Thr Val Ile 
    1700                 1705                 1710             


Asn Arg  Leu Arg Asp Gly Asp  Ser Thr Ser Thr Leu  Glu Glu His 
    1715                 1720                 1725             


Ser Glu  Gly Lys Gln Ile Lys  Asn Leu Pro Glu Glu  Thr Phe Ser 
    1730                 1735                 1740             


Arg Phe  Leu Leu Gln Leu Val  Gly Ile Leu Leu Glu  Asp Ile Val 
    1745                 1750                 1755             


Thr Lys  Gln Leu Lys Val Glu  Met Ser Glu Gln Gln  His Thr Phe 
    1760                 1765                 1770             


Tyr Cys  Gln Glu Leu Gly Thr  Leu Leu Met Cys Leu  Ile His Ile 
    1775                 1780                 1785             


Phe Lys  Ser Gly Met Phe Arg  Arg Ile Thr Ala Ala  Ala Thr Arg 
    1790                 1795                 1800             


Leu Phe  Arg Ser Asp Gly Cys  Gly Gly Ser Phe Tyr  Thr Leu Asp 
    1805                 1810                 1815             


Ser Leu  Asn Leu Arg Ala Arg  Ser Met Ile Thr Thr  His Pro Ala 
    1820                 1825                 1830             


Leu Val  Leu Leu Trp Cys Gln  Ile Leu Leu Leu Val  Asn His Thr 
    1835                 1840                 1845             


Asp Tyr  Arg Trp Trp Ala Glu  Val Gln Gln Thr Pro  Lys Arg His 
    1850                 1855                 1860             


Ser Leu  Ser Ser Thr Lys Leu  Leu Ser Pro Gln Met  Ser Gly Glu 
    1865                 1870                 1875             


Glu Glu  Asp Ser Asp Leu Ala  Ala Lys Leu Gly Met  Cys Asn Arg 
    1880                 1885                 1890             


Glu Ile  Val Arg Arg Gly Ala  Leu Ile Leu Phe Cys  Asp Tyr Val 
    1895                 1900                 1905             


Cys Gln  Asn Leu His Asp Ser  Glu His Leu Thr Trp  Leu Ile Val 
    1910                 1915                 1920             


Asn His  Ile Gln Asp Leu Ile  Ser Leu Ser His Glu  Pro Pro Val 
    1925                 1930                 1935             


Gln Asp  Phe Ile Ser Ala Val  His Arg Asn Ser Ala  Ala Ser Gly 
    1940                 1945                 1950             


Leu Phe  Ile Gln Ala Ile Gln  Ser Arg Cys Glu Asn  Leu Ser Thr 
    1955                 1960                 1965             


Pro Thr  Met Leu Lys Lys Thr  Leu Gln Cys Leu Glu  Gly Ile His 
    1970                 1975                 1980             


Leu Ser  Gln Ser Gly Ala Val  Leu Thr Leu Tyr Val  Asp Arg Leu 
    1985                 1990                 1995             


Leu Cys  Thr Pro Phe Arg Val  Leu Ala Arg Met Val  Asp Ile Leu 
    2000                 2005                 2010             


Ala Cys  Arg Arg Val Glu Met  Leu Leu Ala Ala Asn  Leu Gln Ser 
    2015                 2020                 2025             


Ser Met  Ala Gln Leu Pro Met  Glu Glu Leu Asn Arg  Ile Gln Glu 
    2030                 2035                 2040             


Tyr Leu  Gln Ser Ser Gly Leu  Ala Gln Arg His Gln  Arg Leu Tyr 
    2045                 2050                 2055             


Ser Leu  Leu Asp Arg Phe Arg  Leu Ser Thr Met Gln  Asp Ser Leu 
    2060                 2065                 2070             


Ser Pro  Ser Pro Pro Val Ser  Ser His Pro Leu Asp  Gly Asp Gly 
    2075                 2080                 2085             


His Val  Ser Leu Glu Thr Val  Ser Pro Asp Lys Asp  Trp Tyr Val 
    2090                 2095                 2100             


His Leu  Val Lys Ser Gln Cys  Trp Thr Arg Ser Asp  Ser Ala Leu 
    2105                 2110                 2115             


Leu Glu  Gly Ala Glu Leu Val  Asn Arg Ile Pro Ala  Glu Asp Met 
    2120                 2125                 2130             


Asn Ala  Phe Met Met Asn Ser  Glu Phe Asn Leu Ser  Leu Leu Ala 
    2135                 2140                 2145             


Pro Cys  Leu Ser Leu Gly Met  Ser Glu Ile Ser Gly  Gly Gln Lys 
    2150                 2155                 2160             


Ser Ala  Leu Phe Glu Ala Ala  Arg Glu Val Thr Leu  Ala Arg Val 
    2165                 2170                 2175             


Ser Gly  Thr Val Gln Gln Leu  Pro Ala Val His His  Val Phe Gln 
    2180                 2185                 2190             


Pro Glu  Leu Pro Ala Glu Pro  Ala Ala Tyr Trp Ser  Lys Leu Asn 
    2195                 2200                 2205             


Asp Leu  Phe Gly Asp Ala Ala  Leu Tyr Gln Ser Leu  Pro Thr Leu 
    2210                 2215                 2220             


Ala Arg  Ala Leu Ala Gln Tyr  Leu Val Val Val Ser  Lys Leu Pro 
    2225                 2230                 2235             


Ser His  Leu His Leu Pro Pro  Glu Lys Glu Lys Asp  Ile Val Lys 
    2240                 2245                 2250             


Phe Val  Val Ala Thr Leu Glu  Ala Leu Ser Trp His  Leu Ile His 
    2255                 2260                 2265             


Glu Gln  Ile Pro Leu Ser Leu  Asp Leu Gln Ala Gly  Leu Asp Cys 
    2270                 2275                 2280             


Cys Cys  Leu Ala Leu Gln Leu  Pro Gly Leu Trp Ser  Val Val Ser 
    2285                 2290                 2295             


Ser Thr  Glu Phe Val Thr His  Ala Cys Ser Leu Ile  Tyr Cys Val 
    2300                 2305                 2310             


His Phe  Ile Leu Glu Ala Val  Ala Val Gln Pro Gly  Glu Gln Leu 
    2315                 2320                 2325             


Leu Ser  Pro Glu Arg Arg Thr  Asn Thr Pro Lys Ala  Ile Ser Glu 
    2330                 2335                 2340             


Glu Glu  Glu Glu Val Asp Pro  Asn Thr Gln Asn Pro  Lys Tyr Ile 
    2345                 2350                 2355             


Thr Ala  Ala Cys Glu Met Val  Ala Glu Met Val Glu  Ser Leu Gln 
    2360                 2365                 2370             


Ser Val  Leu Ala Leu Gly His  Lys Arg Asn Ser Gly  Val Pro Ala 
    2375                 2380                 2385             


Phe Leu  Thr Pro Leu Leu Arg  Asn Ile Ile Ile Ser  Leu Ala Arg 
    2390                 2395                 2400             


Leu Pro  Leu Val Asn Ser Tyr  Thr Arg Val Pro Pro  Leu Val Trp 
    2405                 2410                 2415             


Lys Leu  Gly Trp Ser Pro Lys  Pro Gly Gly Asp Phe  Gly Thr Ala 
    2420                 2425                 2430             


Phe Pro  Glu Ile Pro Val Glu  Phe Leu Gln Glu Lys  Glu Val Phe 
    2435                 2440                 2445             


Lys Glu  Phe Ile Tyr Arg Ile  Asn Thr Leu Gly Trp  Thr Ser Arg 
    2450                 2455                 2460             


Thr Gln  Phe Glu Glu Thr Trp  Ala Thr Leu Leu Gly  Val Leu Val 
    2465                 2470                 2475             


Thr Gln  Pro Leu Val Met Glu  Gln Glu Glu Ser Pro  Pro Glu Glu 
    2480                 2485                 2490             


Asp Thr  Glu Arg Thr Gln Ile  Asn Val Leu Ala Val  Gln Ala Ile 
    2495                 2500                 2505             


Thr Ser  Leu Val Leu Ser Ala  Met Thr Val Pro Val  Ala Gly Asn 
    2510                 2515                 2520             


Pro Ala  Val Ser Cys Leu Glu  Gln Gln Pro Arg Asn  Lys Pro Leu 
    2525                 2530                 2535             


Lys Ala  Leu Asp Thr Arg Phe  Gly Arg Lys Leu Ser  Ile Ile Arg 
    2540                 2545                 2550             


Gly Ile  Val Glu Gln Glu Ile  Gln Ala Met Val Ser  Lys Arg Glu 
    2555                 2560                 2565             


Asn Ile  Ala Thr His His Leu  Tyr Gln Ala Trp Asp  Pro Val Pro 
    2570                 2575                 2580             


Ser Leu  Ser Pro Ala Thr Thr  Gly Ala Leu Ile Ser  His Glu Lys 
    2585                 2590                 2595             


Leu Leu  Leu Gln Ile Asn Pro  Glu Arg Glu Leu Gly  Ser Met Ser 
    2600                 2605                 2610             


Tyr Lys  Leu Gly Gln Val Ser  Ile His Ser Val Trp  Leu Gly Asn 
    2615                 2620                 2625             


Ser Ile  Thr Pro Leu Arg Glu  Glu Glu Trp Asp Glu  Glu Glu Glu 
    2630                 2635                 2640             


Glu Glu  Ala Asp Ala Pro Ala  Pro Ser Ser Pro Pro  Thr Ser Pro 
    2645                 2650                 2655             


Val Asn  Ser Arg Lys His Arg  Ala Gly Val Asp Ile  His Ser Cys 
    2660                 2665                 2670             


Ser Gln  Phe Leu Leu Glu Leu  Tyr Ser Arg Trp Ile  Leu Pro Ser 
    2675                 2680                 2685             


Ser Ser  Ala Arg Arg Thr Pro  Ala Ile Leu Ile Ser  Glu Val Val 
    2690                 2695                 2700             


Arg Ser  Leu Leu Val Val Ser  Asp Leu Phe Thr Glu  Arg Asn Gln 
    2705                 2710                 2715             


Phe Glu  Leu Met Tyr Val Thr  Leu Thr Glu Leu Arg  Arg Val His 
    2720                 2725                 2730             


Pro Ser  Glu Asp Glu Ile Leu  Ala Gln Tyr Leu Val  Pro Ala Thr 
    2735                 2740                 2745             


Cys Lys  Ala Ala Ala Val Leu  Gly Met Asp Lys Ala  Val Ala Glu 
    2750                 2755                 2760             


Pro Val  Ser Arg Leu Leu Glu  Ser Thr Leu Arg Ser  Ser His Leu 
    2765                 2770                 2775             


Pro Ser  Arg Val Gly Ala Leu  His Gly Val Leu Tyr  Val Leu Glu 
    2780                 2785                 2790             


Cys Asp  Leu Leu Asp Asp Thr  Ala Lys Gln Leu Ile  Pro Val Ile 
    2795                 2800                 2805             


Ser Asp  Tyr Leu Leu Ser Asn  Leu Lys Gly Ile Ala  His Cys Val 
    2810                 2815                 2820             


Asn Ile  His Ser Gln Gln His  Val Leu Val Met Cys  Ala Thr Ala 
    2825                 2830                 2835             


Phe Tyr  Leu Ile Glu Asn Tyr  Pro Leu Asp Val Gly  Pro Glu Phe 
    2840                 2845                 2850             


Ser Ala  Ser Ile Ile Gln Met  Cys Gly Val Met Leu  Ser Gly Ser 
    2855                 2860                 2865             


Glu Glu  Ser Thr Pro Ser Ile  Ile Tyr His Cys Ala  Leu Arg Gly 
    2870                 2875                 2880             


Leu Glu  Arg Leu Leu Leu Ser  Glu Gln Leu Ser Arg  Leu Asp Ala 
    2885                 2890                 2895             


Glu Ser  Leu Val Lys Leu Ser  Val Asp Arg Val Asn  Val His Ser 
    2900                 2905                 2910             


Pro His  Arg Ala Met Ala Ala  Leu Gly Leu Met Leu  Thr Cys Met 
    2915                 2920                 2925             


Tyr Thr  Gly Lys Glu Lys Val  Ser Pro Gly Arg Thr  Ser Asp Pro 
    2930                 2935                 2940             


Asn Pro  Ala Ala Pro Asp Ser  Glu Ser Val Ile Val  Ala Met Glu 
    2945                 2950                 2955             


Arg Val  Ser Val Leu Phe Asp  Arg Ile Arg Lys Gly  Phe Pro Cys 
    2960                 2965                 2970             


Glu Ala  Arg Val Val Ala Arg  Ile Leu Pro Gln Phe  Leu Asp Asp 
    2975                 2980                 2985             


Phe Phe  Pro Pro Gln Asp Ile  Met Asn Lys Val Ile  Gly Glu Phe 
    2990                 2995                 3000             


Leu Ser  Asn Gln Gln Pro Tyr  Pro Gln Phe Met Ala  Thr Val Val 
    3005                 3010                 3015             


Tyr Lys  Val Phe Gln Thr Leu  His Ser Thr Gly Gln  Ser Ser Met 
    3020                 3025                 3030             


Val Arg  Asp Trp Val Met Leu  Ser Leu Ser Asn Phe  Thr Gln Arg 
    3035                 3040                 3045             


Ala Pro  Val Ala Met Ala Thr  Trp Ser Leu Ser Cys  Phe Phe Val 
    3050                 3055                 3060             


Ser Ala  Ser Thr Ser Pro Trp  Val Ala Ala Ile Leu  Pro His Val 
    3065                 3070                 3075             


Ile Ser  Arg Met Gly Lys Leu  Glu Gln Val Asp Val  Asn Leu Phe 
    3080                 3085                 3090             


Cys Leu  Val Ala Thr Asp Phe  Tyr Arg His Gln Ile  Glu Glu Glu 
    3095                 3100                 3105             


Leu Asp  Arg Arg Ala Phe Gln  Ser Val Leu Glu Val  Val Ala Ala 
    3110                 3115                 3120             


Pro Gly  Ser Pro Tyr His Arg  Leu Leu Thr Cys Leu  Arg Asn Val 
    3125                 3130                 3135             


His Lys  Val Thr Thr Cys 
    3140                 

<210>  164
<211>  563
<212>  DNA
<213>  Homo sapiens

<400>  164
atgcacctga actcaggacc tcttccctgt gcccgtgtcc ctcatacaga cttgctggcc     60

ttccgagcct gctgtgggat cccctacttg ctgcatctta actgtgttcc tcaagtactt    120

gtgataccac ctgctctaaa gaatgctccg ctgttcactc catttttgca gagcccacag    180

gggtcttcct actgcttctt ctacccctgt atttcactca gctctctaaa tttgtctcag    240

ctccaggaag gcagggattt caacctgggc aacaagtcca cagaacatga gatttctgaa    300

ggtgtgtggg atacatcatg gttacataaa aatcctttca ctatagttcc tgcttcccta    360

tcttcaaaat gattccctga agacttccgc catgacggtc taaagcctaa cctctgaact    420

gtggatggaa aattgaactc cttgatgtga tctctgcaca tcatgcaacc ctaaacctaa    480

atatattctc tgtgtgggag ccccattatt tttagtctaa tacattttaa gtcatcttaa    540

aaaattatat tttgttttct ttt                                            563


<210>  165
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  165


Met His Leu Asn Ser Gly Pro Leu Pro Cys Ala Arg Val Pro His Thr 
1               5                   10                  15      


Asp Leu Leu Ala Phe Arg Ala Cys Cys Gly Ile Pro Tyr Leu Leu His 
            20                  25                  30          


Leu Asn Cys Val Pro Gln Val Leu Val Ile Pro Pro Ala Leu Lys Asn 
        35                  40                  45              


Ala Pro Leu Phe Thr Pro Phe Leu Gln Ser Pro Gln Gly Ser Ser Tyr 
    50                  55                  60                  


Cys Phe Phe Tyr Pro Cys Ile Ser Leu Ser Ser Leu Asn Leu Ser Gln 
65                  70                  75                  80  


Leu Gln Glu Gly Arg Asp Phe Asn Leu Gly Asn Lys Ser Thr Glu His 
                85                  90                  95      


Glu Ile Ser Glu Gly Val Trp Asp Thr Ser Trp Leu His Lys Asn Pro 
            100                 105                 110         


Phe Thr Ile Val Pro Ala Ser Leu Ser Ser Lys 
        115                 120             

<210>  166
<211>  4334
<212>  DNA
<213>  Homo sapiens

<400>  166
acgtgcttag gagccatatt gtcgctagtg gccgctgggg ctgggagggg tgtgctagag     60

aggcgcagct tctctgggcg tggtttttat cctgggggaa ggatcggtgg aatgtgaggg    120

gaggtggagg agatggcggc gacggcccgg gaagatggcg ccagcggtca agagcgaggt    180

cagcggggct gcgagcacta tgacagagga tgtctcctaa aggcaccttg ctgtgacaag    240

ctttatactt gccgcttgtg tcatgataac aatgaagatc atcaactaga tcgctttaaa    300

gtgaaggaag tgcagtgcat aaactgtgaa aaaattcaac atgcccaaca gacttgtgaa    360

gaatgtagca cattgtttgg agaatattat tgcgatatat gccatttgtt tgacaaagat    420

aagaagcagt atcactgtga aaactgtgga atttgtagga ttggtccaaa ggaagatttt    480

ttccattgtt tgaaatgtaa cttatgccta gctatgaatc ttcaaggaag acacaagtgt    540

attgaaaatg tgtcccgaca gaattgtcca atatgtttgg aggacattca cacatcccgt    600

gttgttgctc atgtcttgcc atgtggacat cttttacata gaacgtgtta tgaagaaatg    660

ttgaaagagc tacagatgtc cattatgtat gcactctgct ttagatatga ccaggtattg    720

gagacagctg gatgatgaag tagcacagac tcctatgcca tcagaatatc agaacatgac    780

tgtggatatt ctctgcaatg actgtaatgg acgatccact gttcagtttc atatattagg    840

catgaaatgt aagatttgtg aatcctataa tactgctcaa gctggaggac gtagaatttc    900

actggatcag caatgacgag cctacacagt actggagaac ttggcatttt ctgatataga    960

aaaaggcttt ccttggtatc gtgttatcat gtgtcgtcat ctatgcatta gagttgatgt   1020

gttttgtact agtgtcacag cataaaatca tattacaagt acgtaaggat tcagggtctc   1080

ttgatagact tatcatagct ctatattgaa tgaaagccac tgtgcttgtg ttttgattgg   1140

aaattccttt agtgtcagtt ttttggaagc caatgatgtt tgccactgat acattcatag   1200

aagtgtatta tattttcatg aagctttgct ttaagtgaca ctacgcgtgc agttcatttc   1260

tagttcttga tagaactgca cttaattttc agtagtagtc ttgacttttt aagggctgtg   1320

ttatattaag ttctccctta ctgttaaaac ctaattaaat atgctttaga attttctaag   1380

acagtcctct ggatcctcta aatgtgaatt ttgatgtaat aactgctaat aaaattatat   1440

tgaaactgtt ttatagaaag ttttttccaa agttttctat gtttggctca attagggcag   1500

tatcatcagt tctataatgt aaaagaaatt ttctttcttt tgaggtattc cataaaagta   1560

gttgggaaaa ttattatgta aaataataag actcttccaa agccttaata aaaacatcaa   1620

cattgaaaac agtttttttt aggttgccca aaattatttc ttcaaagagt cattcattcc   1680

ttcatttagc aagtatttat tgagcaactg ctatgtggca gatatgtttc tagatgctgt   1740

agagacaaca gtgaacaata aagataaaag tccttgtcct cacagcagta cattctattg   1800

ttcatcatat ttgatcaatg tactcatttt tctttatgca aggagtggat gtcttattgt   1860

aaatgaatag aatatttctt ccctaagcgt gtgaaaatag gggatggatg agtgggaagg   1920

gcatgggata ttcctggcaa gatctctgat ttcataatac ttttttgggc tcatgtagtg   1980

gaattaaata tacctcttac ttcaggaaca aagttaacaa atatgtttga tgatccagcc   2040

gactttgaca ctgttatctc cgtaatagct ttaccattag gctaggatgt aaaatgtaca   2100

tttatcagtt gataagtacc tattgagcac cagttgtatt tccaactttg agctatttga   2160

atcttctttg aataaggaag ttagcctttt aactagaaag cctaagagtt ctggcacatt   2220

tatttcttct tttgttgaaa tttattcacc tagataaagg cagcagtttg ggactcagat   2280

ctttatttta tcccaccttc ttgtcttctg tattccactc ttcttatgtt ctttcccttc   2340

atctgtttcc ttggcctggc cagagcagca gtgctgatct tcatttggga aaggatgttc   2400

ctgggtatta ccaattagta tacagataag taaagactag ttttccagat ctaatacttt   2460

tttttgaagt ggttttgctc tgtcatttag gctagagtgt agtgaagtga tcgtagctca   2520

ctgcagcctt gacttcctgg gctgaactga tccttccacc tcagcctcct gagtagctgg   2580

gactacaggt gtgtgccacc atgcccagct aatttttaat tgttttgtag aaacaaagtc   2640

caggctggtc ttgaactcct gggctcaagc atttctccta cctcggcctt ccaagggcta   2700

ggattacagg catgagccac tgtgcttggt ccagatgtat tactttttat gtttggtatt   2760

attctgccaa accaatcatg ttattgtttt taatcattga atcattggat ctttaaatag   2820

gagtgagtat ataataataa ggctcttctg ttttcaacat ctgtgctggg tcatgcatta   2880

gcattaatta ctacaatgat tctgtggggt aagtgttgtc ctcatagaca agaaagctga   2940

ggtttagagg ttaaaatgac acattggggg taaataacag acactatatg ttggagttgg   3000

gaatcagatc caagtttgac tccaaaccca cttttaccac attgcttttg atctaaactt   3060

ctattttgct aaaatacccc tcacagctag tcatccatat cattgaagcg ctcatgattt   3120

gatagattaa cctttcattt ttttaggtga ctctagttag aaagtcttat ttcacaatct   3180

gattgtttct ttaacttagg atccaaacat gtccaaaata atgcagagta catatgcaat   3240

cactcgttta tgctgtctag tcatgcactt aaagcaattt tcaaatgtac tcaaagtctc   3300

taggcttcgg tacccagggt tgcttcaagt atttgttcat gacacgtcaa ctcgatgatt   3360

aaaatccttc aacacttctc attcacaata agaataaaat ctacatccct taccattcag   3420

tatgcaaaac ttaaaataca taactttacc cttaaatatt ttttctttct ctgacttcat   3480

aagtataggt tatacctcta taagaaagaa ggtaaaaaac tctcaacaat cccttctttc   3540

agagagaact actgttaaca ttttaacaga caacttcatt cttttcctat tcttttttat   3600

aatgcttaca ggaatgttaa atacttagac agatcttaag tacactagaa ttatctgtcc   3660

ctgaaataag ttaggttgcc ctgccgcaga atttgtatct atagtttatt tggattattt   3720

ttgaaaaaag taaaataaca atacccttac gaattttttg gtgcatagca tctcagcttc   3780

ttttatcatt aaagatgtat gtataaaaaa aaaatgagtg tatatcaagt tgttcatttc   3840

ttagtttctg gggtcttctt aaccagtaca tagaactctt tatgaattaa ctttagctta   3900

tgttggaagt agtagtttgt ttatagtgtc atggatttta aaatcaaact cagtttttat   3960

ttcttcacta aaacctattt tcatatgata tacatgttaa atttcccttt tattttggtc   4020

atgcatcaaa ataaatttac taagtactaa agagccaaca ttattttata agtgcctggc   4080

aataggtatt cactagttga atagtttaat ttgaaatgaa ttaattttaa atgggagttg   4140

ttcaaaacta tgccactttt tcttttgtcc tttgtgttat taaaatttaa ttgataattg   4200

tgtatattat atatatggag tacaatgtga tgttttgata tatgtttaca gtgtagaatg   4260

attaaatcaa tgtaataaat ttattgcctc ataccatttt ttgtggtaaa aaaaccaaaa   4320

aaaaaaaaaa aaaa                                                     4334


<210>  167
<211>  200
<212>  PRT
<213>  Homo sapiens

<400>  167


Met Ala Ala Thr Ala Arg Glu Asp Gly Ala Ser Gly Gln Glu Arg Gly 
1               5                   10                  15      


Gln Arg Gly Cys Glu His Tyr Asp Arg Gly Cys Leu Leu Lys Ala Pro 
            20                  25                  30          


Cys Cys Asp Lys Leu Tyr Thr Cys Arg Leu Cys His Asp Asn Asn Glu 
        35                  40                  45              


Asp His Gln Leu Asp Arg Phe Lys Val Lys Glu Val Gln Cys Ile Asn 
    50                  55                  60                  


Cys Glu Lys Ile Gln His Ala Gln Gln Thr Cys Glu Glu Cys Ser Thr 
65                  70                  75                  80  


Leu Phe Gly Glu Tyr Tyr Cys Asp Ile Cys His Leu Phe Asp Lys Asp 
                85                  90                  95      


Lys Lys Gln Tyr His Cys Glu Asn Cys Gly Ile Cys Arg Ile Gly Pro 
            100                 105                 110         


Lys Glu Asp Phe Phe His Cys Leu Lys Cys Asn Leu Cys Leu Ala Met 
        115                 120                 125             


Asn Leu Gln Gly Arg His Lys Cys Ile Glu Asn Val Ser Arg Gln Asn 
    130                 135                 140                 


Cys Pro Ile Cys Leu Glu Asp Ile His Thr Ser Arg Val Val Ala His 
145                 150                 155                 160 


Val Leu Pro Cys Gly His Leu Leu His Arg Thr Cys Tyr Glu Glu Met 
                165                 170                 175     


Leu Lys Glu Leu Gln Met Ser Ile Met Tyr Ala Leu Cys Phe Arg Tyr 
            180                 185                 190         


Asp Gln Val Leu Glu Thr Ala Gly 
        195                 200 

<210>  168
<211>  4309
<212>  DNA
<213>  Homo sapiens

<400>  168
acgtgcttag gagccatatt gtcgctagtg gccgctgggg ctgggagggg tgtgctagag     60

aggcgcagct tctctgggcg tggtttttat cctgggggaa ggatcggtgg aatgtgaggg    120

gaggtggagg agatggcggc gacggcccgg gaagatggcg ccagcggtca agagcgaggt    180

cagcggggct gcgagcacta tgacagagga tgtctcctaa aggcaccttg ctgtgacaag    240

ctttatactt gccgcttgtg tcatgataac aatgaagatc atcaactaga tcgctttaaa    300

gtgaaggaag tgcagtgcat aaactgtgaa aaaattcaac atgcccaaca gacttgtgaa    360

gaatgtagca cattgtttgg agaatattat tgcgatatat gccatttgtt tgacaaagat    420

aagaagcagt atcactgtga aaactgtgga atttgtagga ttggtccaaa ggaagatttt    480

ttccattgtt tgaaatgtaa cttatgccta gctatgaatc ttcaaggaag acacaagtgt    540

attgaaaatg tgtcccgaca gaattgtcca atatgtttgg aggacattca cacatcccgt    600

gttgttgctc atgtcttgcc atgtggacat cttttacata gaggctacag atgtccatta    660

tgtatgcact ctgctttaga tatgaccagg tattggagac agctggatga tgaagtagca    720

cagactccta tgccatcaga atatcagaac atgactgtgg atattctctg caatgactgt    780

aatggacgat ccactgttca gtttcatata ttaggcatga aatgtaagat ttgtgaatcc    840

tataatactg ctcaagctgg aggacgtaga atttcactgg atcagcaatg acgagcctac    900

acagtactgg agaacttggc attttctgat atagaaaaag gctttccttg gtatcgtgtt    960

atcatgtgtc gtcatctatg cattagagtt gatgtgtttt gtactagtgt cacagcataa   1020

aatcatatta caagtacgta aggattcagg gtctcttgat agacttatca tagctctata   1080

ttgaatgaaa gccactgtgc ttgtgttttg attggaaatt cctttagtgt cagttttttg   1140

gaagccaatg atgtttgcca ctgatacatt catagaagtg tattatattt tcatgaagct   1200

ttgctttaag tgacactacg cgtgcagttc atttctagtt cttgatagaa ctgcacttaa   1260

ttttcagtag tagtcttgac tttttaaggg ctgtgttata ttaagttctc ccttactgtt   1320

aaaacctaat taaatatgct ttagaatttt ctaagacagt cctctggatc ctctaaatgt   1380

gaattttgat gtaataactg ctaataaaat tatattgaaa ctgttttata gaaagttttt   1440

tccaaagttt tctatgtttg gctcaattag ggcagtatca tcagttctat aatgtaaaag   1500

aaattttctt tcttttgagg tattccataa aagtagttgg gaaaattatt atgtaaaata   1560

ataagactct tccaaagcct taataaaaac atcaacattg aaaacagttt tttttaggtt   1620

gcccaaaatt atttcttcaa agagtcattc attccttcat ttagcaagta tttattgagc   1680

aactgctatg tggcagatat gtttctagat gctgtagaga caacagtgaa caataaagat   1740

aaaagtcctt gtcctcacag cagtacattc tattgttcat catatttgat caatgtactc   1800

atttttcttt atgcaaggag tggatgtctt attgtaaatg aatagaatat ttcttcccta   1860

agcgtgtgaa aataggggat ggatgagtgg gaagggcatg ggatattcct ggcaagatct   1920

ctgatttcat aatacttttt tgggctcatg tagtggaatt aaatatacct cttacttcag   1980

gaacaaagtt aacaaatatg tttgatgatc cagccgactt tgacactgtt atctccgtaa   2040

tagctttacc attaggctag gatgtaaaat gtacatttat cagttgataa gtacctattg   2100

agcaccagtt gtatttccaa ctttgagcta tttgaatctt ctttgaataa ggaagttagc   2160

cttttaacta gaaagcctaa gagttctggc acatttattt cttcttttgt tgaaatttat   2220

tcacctagat aaaggcagca gtttgggact cagatcttta ttttatccca ccttcttgtc   2280

ttctgtattc cactcttctt atgttctttc ccttcatctg tttccttggc ctggccagag   2340

cagcagtgct gatcttcatt tgggaaagga tgttcctggg tattaccaat tagtatacag   2400

ataagtaaag actagttttc cagatctaat actttttttt gaagtggttt tgctctgtca   2460

tttaggctag agtgtagtga agtgatcgta gctcactgca gccttgactt cctgggctga   2520

actgatcctt ccacctcagc ctcctgagta gctgggacta caggtgtgtg ccaccatgcc   2580

cagctaattt ttaattgttt tgtagaaaca aagtccaggc tggtcttgaa ctcctgggct   2640

caagcatttc tcctacctcg gccttccaag ggctaggatt acaggcatga gccactgtgc   2700

ttggtccaga tgtattactt tttatgtttg gtattattct gccaaaccaa tcatgttatt   2760

gtttttaatc attgaatcat tggatcttta aataggagtg agtatataat aataaggctc   2820

ttctgttttc aacatctgtg ctgggtcatg cattagcatt aattactaca atgattctgt   2880

ggggtaagtg ttgtcctcat agacaagaaa gctgaggttt agaggttaaa atgacacatt   2940

gggggtaaat aacagacact atatgttgga gttgggaatc agatccaagt ttgactccaa   3000

acccactttt accacattgc ttttgatcta aacttctatt ttgctaaaat acccctcaca   3060

gctagtcatc catatcattg aagcgctcat gatttgatag attaaccttt cattttttta   3120

ggtgactcta gttagaaagt cttatttcac aatctgattg tttctttaac ttaggatcca   3180

aacatgtcca aaataatgca gagtacatat gcaatcactc gtttatgctg tctagtcatg   3240

cacttaaagc aattttcaaa tgtactcaaa gtctctaggc ttcggtaccc agggttgctt   3300

caagtatttg ttcatgacac gtcaactcga tgattaaaat ccttcaacac ttctcattca   3360

caataagaat aaaatctaca tcccttacca ttcagtatgc aaaacttaaa atacataact   3420

ttacccttaa atattttttc tttctctgac ttcataagta taggttatac ctctataaga   3480

aagaaggtaa aaaactctca acaatccctt ctttcagaga gaactactgt taacatttta   3540

acagacaact tcattctttt cctattcttt tttataatgc ttacaggaat gttaaatact   3600

tagacagatc ttaagtacac tagaattatc tgtccctgaa ataagttagg ttgccctgcc   3660

gcagaatttg tatctatagt ttatttggat tatttttgaa aaaagtaaaa taacaatacc   3720

cttacgaatt ttttggtgca tagcatctca gcttctttta tcattaaaga tgtatgtata   3780

aaaaaaaaat gagtgtatat caagttgttc atttcttagt ttctggggtc ttcttaacca   3840

gtacatagaa ctctttatga attaacttta gcttatgttg gaagtagtag tttgtttata   3900

gtgtcatgga ttttaaaatc aaactcagtt tttatttctt cactaaaacc tattttcata   3960

tgatatacat gttaaatttc ccttttattt tggtcatgca tcaaaataaa tttactaagt   4020

actaaagagc caacattatt ttataagtgc ctggcaatag gtattcacta gttgaatagt   4080

ttaatttgaa atgaattaat tttaaatggg agttgttcaa aactatgcca ctttttcttt   4140

tgtcctttgt gttattaaaa tttaattgat aattgtgtat attatatata tggagtacaa   4200

tgtgatgttt tgatatatgt ttacagtgta gaatgattaa atcaatgtaa taaatttatt   4260

gcctcatacc attttttgtg gtaaaaaaac caaaaaaaaa aaaaaaaaa               4309


<210>  169
<211>  252
<212>  PRT
<213>  Homo sapiens

<400>  169


Met Ala Ala Thr Ala Arg Glu Asp Gly Ala Ser Gly Gln Glu Arg Gly 
1               5                   10                  15      


Gln Arg Gly Cys Glu His Tyr Asp Arg Gly Cys Leu Leu Lys Ala Pro 
            20                  25                  30          


Cys Cys Asp Lys Leu Tyr Thr Cys Arg Leu Cys His Asp Asn Asn Glu 
        35                  40                  45              


Asp His Gln Leu Asp Arg Phe Lys Val Lys Glu Val Gln Cys Ile Asn 
    50                  55                  60                  


Cys Glu Lys Ile Gln His Ala Gln Gln Thr Cys Glu Glu Cys Ser Thr 
65                  70                  75                  80  


Leu Phe Gly Glu Tyr Tyr Cys Asp Ile Cys His Leu Phe Asp Lys Asp 
                85                  90                  95      


Lys Lys Gln Tyr His Cys Glu Asn Cys Gly Ile Cys Arg Ile Gly Pro 
            100                 105                 110         


Lys Glu Asp Phe Phe His Cys Leu Lys Cys Asn Leu Cys Leu Ala Met 
        115                 120                 125             


Asn Leu Gln Gly Arg His Lys Cys Ile Glu Asn Val Ser Arg Gln Asn 
    130                 135                 140                 


Cys Pro Ile Cys Leu Glu Asp Ile His Thr Ser Arg Val Val Ala His 
145                 150                 155                 160 


Val Leu Pro Cys Gly His Leu Leu His Arg Gly Tyr Arg Cys Pro Leu 
                165                 170                 175     


Cys Met His Ser Ala Leu Asp Met Thr Arg Tyr Trp Arg Gln Leu Asp 
            180                 185                 190         


Asp Glu Val Ala Gln Thr Pro Met Pro Ser Glu Tyr Gln Asn Met Thr 
        195                 200                 205             


Val Asp Ile Leu Cys Asn Asp Cys Asn Gly Arg Ser Thr Val Gln Phe 
    210                 215                 220                 


His Ile Leu Gly Met Lys Cys Lys Ile Cys Glu Ser Tyr Asn Thr Ala 
225                 230                 235                 240 


Gln Ala Gly Gly Arg Arg Ile Ser Leu Asp Gln Gln 
                245                 250         

<210>  170
<211>  4336
<212>  DNA
<213>  Homo sapiens

<400>  170
acgtgcttag gagccatatt gtcgctagtg gccgctgggg ctgggagggg tgtgctagag     60

aggcgcagct tctctgggcg tggtttttat cctgggggaa ggatcggtgg aatgtgaggg    120

gaggtggagg agatggcggc gacggcccgg gaagatggcg ccagcggtca agagcgaggt    180

cagcggggct gcgagcacta tgacagagga tgtctcctaa aggcaccttg ctgtgacaag    240

ctttatactt gccgcttgtg tcatgataac aatgaagatc atcaactaga tcgctttaaa    300

gtgaaggaag tgcagtgcat aaactgtgaa aaaattcaac atgcccaaca gacttgtgaa    360

gaatgtagca cattgtttgg agaatattat tgcgatatat gccatttgtt tgacaaagat    420

aagaagcagt atcactgtga aaactgtgga atttgtagga ttggtccaaa ggaagatttt    480

ttccattgtt tgaaatgtaa cttatgccta gctatgaatc ttcaaggaag acacaagtgt    540

attgaaaatg tgtcccgaca gaattgtcca atatgtttgg aggacattca cacatcccgt    600

gttgttgctc atgtcttgcc atgtggacat cttttacata gaacgtgtta tgaagaaatg    660

ttgaaagaag gctacagatg tccattatgt atgcactctg ctttagatat gaccaggtat    720

tggagacagc tggatgatga agtagcacag actcctatgc catcagaata tcagaacatg    780

actgtggata ttctctgcaa tgactgtaat ggacgatcca ctgttcagtt tcatatatta    840

ggcatgaaat gtaagatttg tgaatcctat aatactgctc aagctggagg acgtagaatt    900

tcactggatc agcaatgacg agcctacaca gtactggaga acttggcatt ttctgatata    960

gaaaaaggct ttccttggta tcgtgttatc atgtgtcgtc atctatgcat tagagttgat   1020

gtgttttgta ctagtgtcac agcataaaat catattacaa gtacgtaagg attcagggtc   1080

tcttgataga cttatcatag ctctatattg aatgaaagcc actgtgcttg tgttttgatt   1140

ggaaattcct ttagtgtcag ttttttggaa gccaatgatg tttgccactg atacattcat   1200

agaagtgtat tatattttca tgaagctttg ctttaagtga cactacgcgt gcagttcatt   1260

tctagttctt gatagaactg cacttaattt tcagtagtag tcttgacttt ttaagggctg   1320

tgttatatta agttctccct tactgttaaa acctaattaa atatgcttta gaattttcta   1380

agacagtcct ctggatcctc taaatgtgaa ttttgatgta ataactgcta ataaaattat   1440

attgaaactg ttttatagaa agttttttcc aaagttttct atgtttggct caattagggc   1500

agtatcatca gttctataat gtaaaagaaa ttttctttct tttgaggtat tccataaaag   1560

tagttgggaa aattattatg taaaataata agactcttcc aaagccttaa taaaaacatc   1620

aacattgaaa acagtttttt ttaggttgcc caaaattatt tcttcaaaga gtcattcatt   1680

ccttcattta gcaagtattt attgagcaac tgctatgtgg cagatatgtt tctagatgct   1740

gtagagacaa cagtgaacaa taaagataaa agtccttgtc ctcacagcag tacattctat   1800

tgttcatcat atttgatcaa tgtactcatt tttctttatg caaggagtgg atgtcttatt   1860

gtaaatgaat agaatatttc ttccctaagc gtgtgaaaat aggggatgga tgagtgggaa   1920

gggcatggga tattcctggc aagatctctg atttcataat acttttttgg gctcatgtag   1980

tggaattaaa tatacctctt acttcaggaa caaagttaac aaatatgttt gatgatccag   2040

ccgactttga cactgttatc tccgtaatag ctttaccatt aggctaggat gtaaaatgta   2100

catttatcag ttgataagta cctattgagc accagttgta tttccaactt tgagctattt   2160

gaatcttctt tgaataagga agttagcctt ttaactagaa agcctaagag ttctggcaca   2220

tttatttctt cttttgttga aatttattca cctagataaa ggcagcagtt tgggactcag   2280

atctttattt tatcccacct tcttgtcttc tgtattccac tcttcttatg ttctttccct   2340

tcatctgttt ccttggcctg gccagagcag cagtgctgat cttcatttgg gaaaggatgt   2400

tcctgggtat taccaattag tatacagata agtaaagact agttttccag atctaatact   2460

tttttttgaa gtggttttgc tctgtcattt aggctagagt gtagtgaagt gatcgtagct   2520

cactgcagcc ttgacttcct gggctgaact gatccttcca cctcagcctc ctgagtagct   2580

gggactacag gtgtgtgcca ccatgcccag ctaattttta attgttttgt agaaacaaag   2640

tccaggctgg tcttgaactc ctgggctcaa gcatttctcc tacctcggcc ttccaagggc   2700

taggattaca ggcatgagcc actgtgcttg gtccagatgt attacttttt atgtttggta   2760

ttattctgcc aaaccaatca tgttattgtt tttaatcatt gaatcattgg atctttaaat   2820

aggagtgagt atataataat aaggctcttc tgttttcaac atctgtgctg ggtcatgcat   2880

tagcattaat tactacaatg attctgtggg gtaagtgttg tcctcataga caagaaagct   2940

gaggtttaga ggttaaaatg acacattggg ggtaaataac agacactata tgttggagtt   3000

gggaatcaga tccaagtttg actccaaacc cacttttacc acattgcttt tgatctaaac   3060

ttctattttg ctaaaatacc cctcacagct agtcatccat atcattgaag cgctcatgat   3120

ttgatagatt aacctttcat ttttttaggt gactctagtt agaaagtctt atttcacaat   3180

ctgattgttt ctttaactta ggatccaaac atgtccaaaa taatgcagag tacatatgca   3240

atcactcgtt tatgctgtct agtcatgcac ttaaagcaat tttcaaatgt actcaaagtc   3300

tctaggcttc ggtacccagg gttgcttcaa gtatttgttc atgacacgtc aactcgatga   3360

ttaaaatcct tcaacacttc tcattcacaa taagaataaa atctacatcc cttaccattc   3420

agtatgcaaa acttaaaata cataacttta cccttaaata ttttttcttt ctctgacttc   3480

ataagtatag gttatacctc tataagaaag aaggtaaaaa actctcaaca atcccttctt   3540

tcagagagaa ctactgttaa cattttaaca gacaacttca ttcttttcct attctttttt   3600

ataatgctta caggaatgtt aaatacttag acagatctta agtacactag aattatctgt   3660

ccctgaaata agttaggttg ccctgccgca gaatttgtat ctatagttta tttggattat   3720

ttttgaaaaa agtaaaataa caataccctt acgaattttt tggtgcatag catctcagct   3780

tcttttatca ttaaagatgt atgtataaaa aaaaaatgag tgtatatcaa gttgttcatt   3840

tcttagtttc tggggtcttc ttaaccagta catagaactc tttatgaatt aactttagct   3900

tatgttggaa gtagtagttt gtttatagtg tcatggattt taaaatcaaa ctcagttttt   3960

atttcttcac taaaacctat tttcatatga tatacatgtt aaatttccct tttattttgg   4020

tcatgcatca aaataaattt actaagtact aaagagccaa cattatttta taagtgcctg   4080

gcaataggta ttcactagtt gaatagttta atttgaaatg aattaatttt aaatgggagt   4140

tgttcaaaac tatgccactt tttcttttgt cctttgtgtt attaaaattt aattgataat   4200

tgtgtatatt atatatatgg agtacaatgt gatgttttga tatatgttta cagtgtagaa   4260

tgattaaatc aatgtaataa atttattgcc tcataccatt ttttgtggta aaaaaaccaa   4320

aaaaaaaaaa aaaaaa                                                   4336


<210>  171
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  171


Met Ala Ala Thr Ala Arg Glu Asp Gly Ala Ser Gly Gln Glu Arg Gly 
1               5                   10                  15      


Gln Arg Gly Cys Glu His Tyr Asp Arg Gly Cys Leu Leu Lys Ala Pro 
            20                  25                  30          


Cys Cys Asp Lys Leu Tyr Thr Cys Arg Leu Cys His Asp Asn Asn Glu 
        35                  40                  45              


Asp His Gln Leu Asp Arg Phe Lys Val Lys Glu Val Gln Cys Ile Asn 
    50                  55                  60                  


Cys Glu Lys Ile Gln His Ala Gln Gln Thr Cys Glu Glu Cys Ser Thr 
65                  70                  75                  80  


Leu Phe Gly Glu Tyr Tyr Cys Asp Ile Cys His Leu Phe Asp Lys Asp 
                85                  90                  95      


Lys Lys Gln Tyr His Cys Glu Asn Cys Gly Ile Cys Arg Ile Gly Pro 
            100                 105                 110         


Lys Glu Asp Phe Phe His Cys Leu Lys Cys Asn Leu Cys Leu Ala Met 
        115                 120                 125             


Asn Leu Gln Gly Arg His Lys Cys Ile Glu Asn Val Ser Arg Gln Asn 
    130                 135                 140                 


Cys Pro Ile Cys Leu Glu Asp Ile His Thr Ser Arg Val Val Ala His 
145                 150                 155                 160 


Val Leu Pro Cys Gly His Leu Leu His Arg Thr Cys Tyr Glu Glu Met 
                165                 170                 175     


Leu Lys Glu Gly Tyr Arg Cys Pro Leu Cys Met His Ser Ala Leu Asp 
            180                 185                 190         


Met Thr Arg Tyr Trp Arg Gln Leu Asp Asp Glu Val Ala Gln Thr Pro 
        195                 200                 205             


Met Pro Ser Glu Tyr Gln Asn Met Thr Val Asp Ile Leu Cys Asn Asp 
    210                 215                 220                 


Cys Asn Gly Arg Ser Thr Val Gln Phe His Ile Leu Gly Met Lys Cys 
225                 230                 235                 240 


Lys Ile Cys Glu Ser Tyr Asn Thr Ala Gln Ala Gly Gly Arg Arg Ile 
                245                 250                 255     


Ser Leu Asp Gln Gln 
            260     

<210>  172
<211>  3578
<212>  DNA
<213>  Homo sapiens

<400>  172
tcccggggct acgaggcgga agcgaaggca gacgcagtct ccgtcgttga cgttagtcgc     60

agtcttcgct gctaacgttt tgttatgagt tgctaaaatg gtgaaatgct gctccgccat    120

tggatgtgct tctcgctgct tgccaaattc gaagttaaaa ggactgacat ttcacgtatt    180

ccccacagat gaaaacatca aaaggaaatg ggtattagca atgaaaagac ttgatgtgaa    240

tgcagccggc atttgggagc ctaaaaaagg agatgtgttg tgttcgaggc actttaagaa    300

gacagatttt gacagaagtg ctccaaatat taaactgaaa cctggagtca taccttctat    360

ctttgattct ccatatcacc tacaggggaa aagagaaaaa cttcattgta gaaaaaactt    420

caccctcaaa accgttccag ccactaacta caatcaccat cttgttggtg cttcctcatg    480

tattgaagaa ttccaatccc agttcatttt tgaacatagc tacagtgtaa tggacagtcc    540

aaagaaactt aagcataaat tagatcatgt gatcggcgag ctagaggata caaaggaaag    600

tctacggaat gttttagacc gagaaaaacg ttttcagaaa tcattgagga agacaatcag    660

ggaattaaag gatgaatgtc tgatcagcca agaaacagca aatagactgg acactttctg    720

ttgggactgt tgtcaggaga gcatagaaca ggactatatt tcatgaaata atttcatgtt    780

acgttccacc taaaattgtc attggtacaa atttttataa aatctcattt accatcacta    840

aataatatcc atcatttaaa gtgctgcttt ggattctctg gagcattatg cattatagtt    900

gttatccaaa gacttttttg aaaatatgca gaaatttgtg gtaattatgt atttgtgtct    960

tgtgacaatt atgttttata gacctacact agtgccaggt cactattgta agatgttaaa   1020

atctcaagaa aatttcacag agctaaagaa atgatgtcaa attagtcaca ttaagctata   1080

gtagaaggaa ttggacactt ctccagatat ttggcttcaa aggagtacct ttacttacat   1140

gtgctttatg gtaagtacat tgaattttac tttaaatgca ttttactaca aagcacaatt   1200

catttgtaat gcatatccat cttggattca atccaaggtg ctttagctat cagtagtacc   1260

aaaggatctt tttacaaggc ttcctgtggt attgactctg agaataacac atagtgaaga   1320

tctgtgggct tttaaaattg ttcacagcca atttaagaag acccctcatg aagtctcagt   1380

tttcagtaca gtacatcatt cctcctcact aggagcactt tgatgtaaac cagaatagct   1440

ttaaaaagac aaaaaggatc gtagatctga tttttaaatg gttggttgct ctgacagatc   1500

tgaacacttt gcttcatgac tatttcgtca taaaggtata tgtttaaaat ctgaatggca   1560

gtactagctc tatactttta atactgcttt gtattttata tgtaaagtag tattgctgac   1620

attttaaaaa aatacaaaat acaaaagaaa ccattagaaa ttaataactg tggctcttcc   1680

agttgaaata ggaattggag agaaaggatt agaatatttt aattagggga gtagattatt   1740

gtccaaaggc ttttatttag agaaacgggt aattaaaaca gcagctttag aatagcttct   1800

tactgaatat gcaaaagaat aattccttgt tatttcctaa ttgatccaag tctcataaat   1860

ttagcttttg tcataattcc ttaccgaaaa caactgaaat tgagagtcat aaatactgtg   1920

ggttagaata aaaaccattt gccaaagcaa cactctactt agaagcacat gtacatacat   1980

ggacctcatt cagaagtcca tgttgtagca gttagaattt gagtatcagc catttcattg   2040

tagtaacaaa aattgaattg cattttgtgc tcagttgttt attgtaattt tatttttgtt   2100

acattaatat tagttaagat atggtcactt gaattttttg tatttaagaa ttttctgttt   2160

taatgcatgt tatactttta tgtaggattc caaaccttcc ctctaaatgg gatttaaccc   2220

acatctgcga gatcagcgtt atgctaagag gaaatcactg aggccatatc tttttacaat   2280

ctgaaaaaaa agtagtaaaa aggtagttaa aaaaaaaaaa ggccgggtgg tggctcatac   2340

ctgtaatcct agcactttgg gaggccaagg caggcagatc acttgaggtc aggggttcaa   2400

aaccagcctg gccaagatgg tgaaacccca tctctgctaa aaatacaaaa aaaaattagc   2460

cgggcatggt ggcacgtgcc tgtaatccca gctacttggg agactgaggc aggagaattg   2520

cttgaacccg ggaggcggag attgcagtga gccaagatca cgccgttgca ctccagcctg   2580

agcaacagag caagactcca tctcaaaaaa acaaaactac tttcattaat tacccattat   2640

ttattttagt tacttaattt tgagttcata aatggccacc ctaatggaaa gtttgggtat   2700

gatcttaggt tttatggaga tgttttcaat agagattatt tttccctcac cctatttgtg   2760

aatatataaa ttaaagtaag acaatggagt aagtaagagg gtagatccaa acacagtatg   2820

tctaaattct agcactctac tggctgctta gaatacacca aacctggaag acctttccaa   2880

gagtaaaatc ccagtctgcc actatcaaaa ttgccacagt cacttttact acttgtgttc   2940

atagtagact cagcacttct ttttcactgg acctagtata actgagaaat aaataactgt   3000

gtgcaaaata ttggtatcat taaggaccca gagctgccca ttttctcttt gttctaatag   3060

ggaagcaatt actgatagaa atgtgagatt aaaaataggg tcctccctgc tgctccaaac   3120

aaatgcctaa acacagtatg tatctcagtc ctctgttccc agagattcca ccctagccca   3180

ggaaagaact ggcctgtgta aagcaaaacc caagtcatcc ccctccagaa atttctctgg   3240

cagccaagcc tgaccctaag ggttccactt tgctttaaaa gctaggagtg gcctctagag   3300

ccaggaacac attaatacaa cagttcaacc tcagcaccaa gtcaggtacg aagcgcttga   3360

tacgtggaat ttttctctat atcaagttta aatttctgga aatagacttt ggttgctaat   3420

gacaattaca gttataccat agtctgtaat ttgagaaaag gtgaaatgta tttaatatat   3480

atttagtttt aataaaaaga taaaattatt acagaaataa ttgagagaga gaaaatctat   3540

tataatttat ttgaaaaata aaacatttta tccagtaa                           3578


<210>  173
<211>  222
<212>  PRT
<213>  Homo sapiens

<400>  173


Met Val Lys Cys Cys Ser Ala Ile Gly Cys Ala Ser Arg Cys Leu Pro 
1               5                   10                  15      


Asn Ser Lys Leu Lys Gly Leu Thr Phe His Val Phe Pro Thr Asp Glu 
            20                  25                  30          


Asn Ile Lys Arg Lys Trp Val Leu Ala Met Lys Arg Leu Asp Val Asn 
        35                  40                  45              


Ala Ala Gly Ile Trp Glu Pro Lys Lys Gly Asp Val Leu Cys Ser Arg 
    50                  55                  60                  


His Phe Lys Lys Thr Asp Phe Asp Arg Ser Ala Pro Asn Ile Lys Leu 
65                  70                  75                  80  


Lys Pro Gly Val Ile Pro Ser Ile Phe Asp Ser Pro Tyr His Leu Gln 
                85                  90                  95      


Gly Lys Arg Glu Lys Leu His Cys Arg Lys Asn Phe Thr Leu Lys Thr 
            100                 105                 110         


Val Pro Ala Thr Asn Tyr Asn His His Leu Val Gly Ala Ser Ser Cys 
        115                 120                 125             


Ile Glu Glu Phe Gln Ser Gln Phe Ile Phe Glu His Ser Tyr Ser Val 
    130                 135                 140                 


Met Asp Ser Pro Lys Lys Leu Lys His Lys Leu Asp His Val Ile Gly 
145                 150                 155                 160 


Glu Leu Glu Asp Thr Lys Glu Ser Leu Arg Asn Val Leu Asp Arg Glu 
                165                 170                 175     


Lys Arg Phe Gln Lys Ser Leu Arg Lys Thr Ile Arg Glu Leu Lys Asp 
            180                 185                 190         


Glu Cys Leu Ile Ser Gln Glu Thr Ala Asn Arg Leu Asp Thr Phe Cys 
        195                 200                 205             


Trp Asp Cys Cys Gln Glu Ser Ile Glu Gln Asp Tyr Ile Ser 
    210                 215                 220         

<210>  174
<211>  744
<212>  DNA
<213>  Homo sapiens

<400>  174
atcaggttca acgcagtgac tgctcagtag aagccatggc tcgcagacac tgcttctcct     60

actggttact ggtatgctgg ttggtggtaa ctgtggcaga aggacaagaa gaggtattta    120

cgcttcctgg agattcacaa aataatgcgg acgctaccga ctgccagatc tttacactca    180

cccctccacc tgccccgagg agtccggtca caagggccca gcccatcaca aagacaccca    240

ggtgtccctt ccattttttt ccacgaaggc ccagaatcca ttttaggttt ccaaacagac    300

ctttcgtccc ttcaaggtgt aaccaccgtt ttccattcca gccattttat tggccacacc    360

gttaccttac ttataggtat ttccccagaa gaagactcca gagaggaagc tcatctgagg    420

aaagctgaga gggaagagaa acccaaacat actgaagcaa aaaaaagcct atccttcaga    480

aaaaagcaac aaaaagattt ctgttttatc tttcgaaact aaaactattg gatttgaaga    540

ttaagtatcc taaacatcac tgactagaaa ctgttctctt tgtcagcagt gaagatattg    600

gatcataggt tattgatggt tgcaaaattg gacaataacc acgttatttt tatcctcaac    660

ctcttatggt cacaggatat ttatgcaaat aaaatcttta aatgggaaaa aaaaaaaaaa    720

aaaaaaaaaa aaaaaaaaaa aaaa                                           744


<210>  175
<211>  130
<212>  PRT
<213>  Homo sapiens

<400>  175


Met Ala Arg Arg His Cys Phe Ser Tyr Trp Leu Leu Val Cys Trp Leu 
1               5                   10                  15      


Val Val Thr Val Ala Glu Gly Gln Glu Glu Val Phe Thr Leu Pro Gly 
            20                  25                  30          


Asp Ser Gln Asn Asn Ala Asp Ala Thr Asp Cys Gln Ile Phe Thr Leu 
        35                  40                  45              


Thr Pro Pro Pro Ala Pro Arg Ser Pro Val Thr Arg Ala Gln Pro Ile 
    50                  55                  60                  


Thr Lys Thr Pro Arg Cys Pro Phe His Phe Phe Pro Arg Arg Pro Arg 
65                  70                  75                  80  


Ile His Phe Arg Phe Pro Asn Arg Pro Phe Val Pro Ser Arg Cys Asn 
                85                  90                  95      


His Arg Phe Pro Phe Gln Pro Phe Tyr Trp Pro His Arg Tyr Leu Thr 
            100                 105                 110         


Tyr Arg Tyr Phe Pro Arg Arg Arg Leu Gln Arg Gly Ser Ser Ser Glu 
        115                 120                 125             


Glu Ser 
    130 

<210>  176
<211>  4717
<212>  DNA
<213>  Homo sapiens

<400>  176
aaccgccccc ccttgcagct ccgcggccaa cgccttcgcc caggggtagt tggagcggtg     60

caggttccca ggctccaggt actgggcgcc ttacgagctg ggaggtggtg cctctcaccc    120

agctaattgc tctctagccc ttggccttca caggtgttgg tgcctgccgt gaacgcattc    180

tgacctgggc cgtatctgtc tcccaagact ttgtgcctat ggttggggac agagtgaggt    240

cgttgccttg acgacgacag catgcggccc gtggtcctcc taagtgtgag cttgcggcgg    300

accgaggccc acctgcctcc ctgcctgctt cgccctggac tcgtgactgc gtccgcagaa    360

gaaatcacaa cagcgctgga attgctagtt tgctaggcag catcttttgg acctgcgaac    420

catatgcatt tcacctcaaa tttgtttcca agttgaaaac ctttgggtct ttctatgcga    480

acggattgaa gaaacgcaaa aagtttctac ggactttaaa ttaaaatgga aaaatatgaa    540

aacctgggtt tggttggaga agggagttat ggaatggtga tgaagtgtag gaataaagat    600

actggaagaa ttgtggccat aaagaagttc ttagaaagtg acgatgacaa aatggttaaa    660

aagattgcaa tgcgagaaat caagttacta aagcaactta ggcatgaaaa cttggtgaat    720

ctcttggaag tgtgtaagaa aaaaaaacga tggtacctag tctttgaatt tgttgaccac    780

acaattcttg atgacttgga gctctttcca aatggactag actaccaagt agttcaaaag    840

tatttgtttc agattattaa tggaattgga ttttgtcaca gtcacaatat catacacaga    900

gatataaagc cagagaatat attagtctcc cagtctggcg ttgtcaagct atgcgatttt    960

ggatttgcgc gaacattggc agctcctggg gaggtttata ctgattatgt ggcaacccga   1020

tggtacagag ctccagaact attggttggt gatgtcaagt atggcaaggc tgttgatgtg   1080

tgggccattg gttgtctggt aactgaaatg ttcatggggg aacccctatt tcctggagat   1140

tctgatattg atcagctata tcatattatg atgtgtttag gtaatctaat tccaaggcat   1200

caggagcttt ttaataaaaa tcctgtgttt gctggagtaa ggttgcctga aatcaaggaa   1260

agagaacctc ttgaaagacg ctatcctaag ctctctgaag tggtgataga tttagcaaag   1320

aaatgcttac atattgaccc cgacaaaaga cccttctgtg ctgagctcct acaccatgat   1380

ttctttcaaa tggatggatt tgctgagagg ttttcccaag aactacagtt aaaagtacag   1440

aaagatgcca gaaatgtttc tttatctaaa aaatcccaaa acagaaagaa ggaaaaagaa   1500

aaagatgatt ccttagttga agaaagaaaa acacttgtgg tacaggatac caatgctgat   1560

cccaaaatta aggattataa actatttaaa ataaaaggct caaaaattga tggagaaaaa   1620

gctgaaaaag gcaatagagc ttcaaatgcc agctgtctcc atgacagtag gacaagccac   1680

aacaaaatag tgccttcaac aagcctcaaa gactgcagca atgtcagcgt ggaccacaca   1740

aggaatccaa gcgtggcaat tcccccactt acacacaatc tttctgcagt tgctcccagc   1800

attaattctg gaatggggac tgagactata ccaattcagg gttacagagt ggatgagaaa   1860

actaagaagt gttctattcc atttgttaaa ccgaacagac attccccatc aggcatttat   1920

aacattaatg tgaccacatt agtatcagga cctcccctgt cagatgattc aggggctgat   1980

ttgcctcaaa tggaacacca gcactgagaa ccattttggt tctgaactgg atgatgctct   2040

tgcacttgag atgacatctt cttgcagcaa gagtgctgat atcccaagag gagagattca   2100

tggttttgat catttccttc tgaactgcct gcattttctg aggaaggcct tctagaagaa   2160

ggaaagacaa agacttccaa atgtttcaaa ggaagattga acaaatggcc ctccccaact   2220

gttatcccat tacctttcac gtccaccgat gctatttcaa gacatatcca gtggaataac   2280

agtgatatgg ttcttgttac atgaatgtgt atttactgtt aggagattgt atattttaag   2340

ttaccatgat taaaagtgtg taaaaaaggg ggacagagag aaatactata aaaggccatg   2400

ttactcatgc attgaacttt gtgtgttttc tgtataaatg tgtacattta tttaggagtg   2460

ggtttcttgg gggtaggtga taaaaattag gatcagttga agaaaattga agaaactagg   2520

atcagtaaga gaaactgttt gctttacctg aatttaacta tgaaaacaca cttaacaatc   2580

ttacacgttt ctagatatta agtgaatatg taactcctgt ccatgggtag atgtgtatct   2640

ttgacttctg taattatttt tgatattcta tcagtgtatt atgagactct ggcctccctg   2700

cagatcttct aagaaccaca ctaatgcaag cgtgacagag aaacctcttt cgaatgactt   2760

actacaactc tggcattggt tagttccatg tattgtaaga ttctggtgct aatgctccat   2820

acagaattga tcaggactga ttactcttct gtggaccaat tgctattgaa ctacccagct   2880

gaagagggtt tggggagaga acgttcatta ttatggactc cacttttgtc ccctggtagt   2940

ttaagggtga tactagaatc cagagaagtt cctgtctcct tgtggcctca aacactcagg   3000

ccgtctcaaa agcttttcac caaggtgcaa aatcatttac ctgcattcca cacatctttt   3060

ccaatgcatg gatccaaaac tttttaggtg ggaggaataa actaagttgg ctacaggttc   3120

ttgatttctg ggtttctaca catgctctgc atttatcatt ttagagaatg gttgtttagg   3180

gaaccagaat ttgtgagttt tttttttttt tttgccttaa ctaattaata gtgtgttgct   3240

ttttttccaa agccattgac tagaacttag ctgaagaatt taactagaac ttttctttat   3300

tactctgagg agcttaatac tgaaattctg accttggata tttaagcctc aaaagagtag   3360

gacattcaag aggaggcaaa taaggggttt caatgtacaa gtctataggt ggtggttaaa   3420

ttaaaattgg tcttgattta aaagctctac ttttaatctg tgaccagctg tttgacaaca   3480

ttagtatgga taacatgctg aaaaaactag ggtatcagca ttaataggct gcatattaaa   3540

aagttactac tttattttta ctttgaaaaa cactgccaat agattctgca gcatggcaaa   3600

caggtaatac ttaaagccaa atggcgcttc ggcttatttc aatactattt ttatgtaaag   3660

atcagtgtga gaatatcagc tcaatggttg aggttctagg atcaattgcc ttgcagtttt   3720

tatactagct tttgatatct tttgcctatt aaaacacttt gtgaacttta gaattaagga   3780

actaaaaaat atttaccata agtccaagtt atgacttgag gatcatatct gattagaact   3840

gtggcagaac tactagaaaa agattctgca aattggtttc agtgattctt gttgatgtaa   3900

tcaacaagat tacataatca acaataatag atattgaacc aaaatgatcc tttttttaag   3960

tttaaggtta tttagtttct cttgcaagga tatgatttag tcacacacta atagggaata   4020

tgtgtatgta ctggtgggga gcagtgggct tgctgcatgt atgtatgttt taaaattaat   4080

aaatattatc ttactgggct ccatagatgg tttaaattta gatttattta attaagaggc   4140

tataaataat atatacacta ctgtatggta tttaacaaat aagttttaaa tctgttaatt   4200

cttctggaaa actttggatg tagggatggc aagctaattt tcttgtatag ctggtgatat   4260

aagcagcatg gtcataaaat aacatttctt ataaagacta actggtaata gttgtgacag   4320

aacctggttt tcctgactga gaatcccttg cttgcttaga atatctgact tcccattgaa   4380

atggaacata gaaaatgtgt tttcttatgt gactctcatt attggttcct ttatcttagt   4440

tgtgctacaa tataaggctg gacctgtaat acactatgta tcagactaga ctgaaaaatg   4500

tgatcgattt gttttctaag tcctcctcta tataactgaa ccatggtcag gggattagag   4560

aagcaacaga gcactgctcc taaggcttta ggctagtctt agtgaattgg actgaatgga   4620

tttttctctg ttgttttttg cattaagtgt ttttgcacta gaagagggtg cttaacactc   4680

ctctatctat atgaataaaa aattatgttc tcacaaa                            4717


<210>  177
<211>  493
<212>  PRT
<213>  Homo sapiens

<400>  177


Met Glu Lys Tyr Glu Asn Leu Gly Leu Val Gly Glu Gly Ser Tyr Gly 
1               5                   10                  15      


Met Val Met Lys Cys Arg Asn Lys Asp Thr Gly Arg Ile Val Ala Ile 
            20                  25                  30          


Lys Lys Phe Leu Glu Ser Asp Asp Asp Lys Met Val Lys Lys Ile Ala 
        35                  40                  45              


Met Arg Glu Ile Lys Leu Leu Lys Gln Leu Arg His Glu Asn Leu Val 
    50                  55                  60                  


Asn Leu Leu Glu Val Cys Lys Lys Lys Lys Arg Trp Tyr Leu Val Phe 
65                  70                  75                  80  


Glu Phe Val Asp His Thr Ile Leu Asp Asp Leu Glu Leu Phe Pro Asn 
                85                  90                  95      


Gly Leu Asp Tyr Gln Val Val Gln Lys Tyr Leu Phe Gln Ile Ile Asn 
            100                 105                 110         


Gly Ile Gly Phe Cys His Ser His Asn Ile Ile His Arg Asp Ile Lys 
        115                 120                 125             


Pro Glu Asn Ile Leu Val Ser Gln Ser Gly Val Val Lys Leu Cys Asp 
    130                 135                 140                 


Phe Gly Phe Ala Arg Thr Leu Ala Ala Pro Gly Glu Val Tyr Thr Asp 
145                 150                 155                 160 


Tyr Val Ala Thr Arg Trp Tyr Arg Ala Pro Glu Leu Leu Val Gly Asp 
                165                 170                 175     


Val Lys Tyr Gly Lys Ala Val Asp Val Trp Ala Ile Gly Cys Leu Val 
            180                 185                 190         


Thr Glu Met Phe Met Gly Glu Pro Leu Phe Pro Gly Asp Ser Asp Ile 
        195                 200                 205             


Asp Gln Leu Tyr His Ile Met Met Cys Leu Gly Asn Leu Ile Pro Arg 
    210                 215                 220                 


His Gln Glu Leu Phe Asn Lys Asn Pro Val Phe Ala Gly Val Arg Leu 
225                 230                 235                 240 


Pro Glu Ile Lys Glu Arg Glu Pro Leu Glu Arg Arg Tyr Pro Lys Leu 
                245                 250                 255     


Ser Glu Val Val Ile Asp Leu Ala Lys Lys Cys Leu His Ile Asp Pro 
            260                 265                 270         


Asp Lys Arg Pro Phe Cys Ala Glu Leu Leu His His Asp Phe Phe Gln 
        275                 280                 285             


Met Asp Gly Phe Ala Glu Arg Phe Ser Gln Glu Leu Gln Leu Lys Val 
    290                 295                 300                 


Gln Lys Asp Ala Arg Asn Val Ser Leu Ser Lys Lys Ser Gln Asn Arg 
305                 310                 315                 320 


Lys Lys Glu Lys Glu Lys Asp Asp Ser Leu Val Glu Glu Arg Lys Thr 
                325                 330                 335     


Leu Val Val Gln Asp Thr Asn Ala Asp Pro Lys Ile Lys Asp Tyr Lys 
            340                 345                 350         


Leu Phe Lys Ile Lys Gly Ser Lys Ile Asp Gly Glu Lys Ala Glu Lys 
        355                 360                 365             


Gly Asn Arg Ala Ser Asn Ala Ser Cys Leu His Asp Ser Arg Thr Ser 
    370                 375                 380                 


His Asn Lys Ile Val Pro Ser Thr Ser Leu Lys Asp Cys Ser Asn Val 
385                 390                 395                 400 


Ser Val Asp His Thr Arg Asn Pro Ser Val Ala Ile Pro Pro Leu Thr 
                405                 410                 415     


His Asn Leu Ser Ala Val Ala Pro Ser Ile Asn Ser Gly Met Gly Thr 
            420                 425                 430         


Glu Thr Ile Pro Ile Gln Gly Tyr Arg Val Asp Glu Lys Thr Lys Lys 
        435                 440                 445             


Cys Ser Ile Pro Phe Val Lys Pro Asn Arg His Ser Pro Ser Gly Ile 
    450                 455                 460                 


Tyr Asn Ile Asn Val Thr Thr Leu Val Ser Gly Pro Pro Leu Ser Asp 
465                 470                 475                 480 


Asp Ser Gly Ala Asp Leu Pro Gln Met Glu His Gln His 
                485                 490             

<210>  178
<211>  4913
<212>  DNA
<213>  Homo sapiens

<400>  178
aaaaagagaa actgttggga gaggaatcgt atctccatat ttcttctttc agccccaatc     60

caagggttgt agctggaact ttccatcagt tcttcctttc tttttcctct ctaagccttt    120

gccttgctct gtcacagtga agtcagccag agcagggctg ttaaactctg tgaaatttgt    180

cataagggtg tcaggtattt cttactggct tccaaagaaa catagataaa gaaatctttc    240

ctgtggcttc ccttggcagg ctgcattcag aaggtctctc agttgaagaa agagcttgga    300

ggacaacagc acaacaggag agtaaaagat gccccagggc tgaggcctcc gctcaggcag    360

ccgcatctgg ggtcaatcat actcaccttg cccgggccat gctccagcaa aatcaagctg    420

ttttcttttg aaagttcaaa ctcatcaaga ttatgctgct cactcttatc attctgttgc    480

cagtagtttc aaaatttagt tttgttagtc tctcagcacc gcagcactgg agctgtcctg    540

aaggtactct cgcaggaaat gggaattcta cttgtgtggg tcctgcaccc ttcttaattt    600

tctcccatgg aaatagtatc tttaggattg acacagaagg aaccaattat gagcaattgg    660

tggtggatgc tggtgtctca gtgatcatgg attttcatta taatgagaaa agaatctatt    720

gggtggattt agaaagacaa cttttgcaaa gagtttttct gaatgggtca aggcaagaga    780

gagtatgtaa tatagagaaa aatgtttctg gaatggcaat aaattggata aatgaagaag    840

ttatttggtc aaatcaacag gaaggaatca ttacagtaac agatatgaaa ggaaataatt    900

cccacattct tttaagtgct ttaaaatatc ctgcaaatgt agcagttgat ccagtagaaa    960

ggtttatatt ttggtcttca gaggtggctg gaagccttta tagagcagat ctcgatggtg   1020

tgggagtgaa ggctctgttg gagacatcag agaaaataac agctgtgtca ttggatgtgc   1080

ttgataagcg gctgttttgg attcagtaca acagagaagg aagcaattct cttatttgct   1140

cctgtgatta tgatggaggt tctgtccaca ttagtaaaca tccaacacag cataatttgt   1200

ttgcaatgtc cctttttggt gaccgtatct tctattcaac atggaaaatg aagacaattt   1260

ggatagccaa caaacacact ggaaaggaca tggttagaat taacctccat tcatcatttg   1320

taccacttgg tgaactgaaa gtagtgcatc cacttgcaca acccaaggca gaagatgaca   1380

cttgggagcc tgagcagaaa ctttgcaaat tgaggaaagg aaactgcagc agcactgtgt   1440

gtgggcaaga cctccagtca cacttgtgca tgtgtgcaga gggatacgcc ctaagtcgag   1500

accggaagta ctgtgaagat gttaatgaat gtgctttttg gaatcatggc tgtactcttg   1560

ggtgtaaaaa cacccctgga tcctattact gcacgtgccc tgtaggattt gttctgcttc   1620

ctgatgggaa acgatgtcat caacttgttt cctgtccacg caatgtgtct gaatgcagcc   1680

atgactgtgt tctgacatca gaaggtccct tatgtttctg tcctgaaggc tcagtgcttg   1740

agagagatgg gaaaacatgt agcggttgtt cctcacccga taatggtgga tgtagccagc   1800

tctgcgttcc tcttagccca gtatcctggg aatgtgattg ctttcctggg tatgacctac   1860

aactggatga aaaaagctgt gcagcttcag gaccacaacc atttttgctg tttgccaatt   1920

ctcaagatat tcgacacatg cattttgatg gaacagacta tggaactctg ctcagccagc   1980

agatgggaat ggtttatgcc ctagatcatg accctgtgga aaataagata tactttgccc   2040

atacagccct gaagtggata gagagagcta atatggatgg ttcccagcga gaaaggctta   2100

ttgaggaagg agtagatgtg ccagaaggtc ttgctgtgga ctggattggc cgtagattct   2160

attggacaga cagagggaaa tctctgattg gaaggagtga tttaaatggg aaacgttcca   2220

aaataatcac taaggagaac atctctcaac cacgaggaat tgctgttcat ccaatggcca   2280

agagattatt ctggactgat acagggatta atccacgaat tgaaagttct tccctccaag   2340

gccttggccg tctggttata gccagctctg atctaatctg gcccagtgga ataacgattg   2400

acttcttaac tgacaagttg tactggtgcg atgccaagca gtctgtgatt gaaatggcca   2460

atctggatgg ttcaaaacgc cgaagactta cccagaatga tgtaggtcac ccatttgctg   2520

tagcagtgtt tgaggattat gtgtggttct cagattgggc tatgccatca gtaatgagag   2580

taaacaagag gactggcaaa gatagagtac gtctccaagg cagcatgctg aagccctcat   2640

cactggttgt ggttcatcca ttggcaaaac caggagcaga tccctgctta tatcaaaacg   2700

gaggctgtga acatatttgc aaaaagaggc ttggaactgc ttggtgttcg tgtcgtgaag   2760

gttttatgaa agcctcagat gggaaaacgt gtctggctct ggatggtcat cagctgttgg   2820

caggtggtga agttgatcta aagaaccaag taacaccatt ggacatcttg tccaagacta   2880

gagtgtcaga agataacatt acagaatctc aacacatgct agtggctgaa atcatggtgt   2940

cagatcaaga tgactgtgct cctgtgggat gcagcatgta tgctcggtgt atttcagagg   3000

gagaggatgc cacatgtcag tgtttgaaag gatttgctgg ggatggaaaa ctatgttctg   3060

atatagatga atgtgagatg ggtgtcccag tgtgcccccc tgcctcctcc aagtgcatca   3120

acaccgaagg tggttatgtc tgccggtgct cagaaggcta ccaaggagat gggattcact   3180

gtcttgatat tgatgagtgc caactggggg agcacagctg tggagagaat gccagctgca   3240

caaatacaga gggaggctat acctgcatgt gtgctggacg cctgtctgaa ccaggactga   3300

tttgccctga ctctactcca ccccctcacc tcagggaaga tgaccaccac tattccgtaa   3360

gaaatagtga ctctgaatgt cccctgtccc acgatgggta ctgcctccat gatggtgtgt   3420

gcatgtatat tgaagcattg gacaagtatg catgcaactg tgttgttggc tacatcgggg   3480

agcgatgtca gtaccgagac ctgaagtggt gggaactgcg ccacgctggc cacgggcagc   3540

agcagaaggt catcgtggtg gctgtctgcg tggtggtgct tgtcatgctg ctcctcctga   3600

gcctgtgggg ggcccactac tacaggactc agaagctgct atcgaaaaac ccaaagaatc   3660

cttatgagga gtcgagcaga gatgtgagga gtcgcaggcc tgctgacact gaggatggga   3720

tgtcctcttg ccctcaacct tggtttgtgg ttataaaaga acaccaagac ctcaagaatg   3780

ggggtcaacc agtggctggt gaggatggcc aggcagcaga tgggtcaatg caaccaactt   3840

catggaggca ggagccccag ttatgtggaa tgggcacaga gcaaggctgc tggattccag   3900

tatccagtga taagggctcc tgtccccagg taatggagcg aagctttcat atgccctcct   3960

atgggacaca gacccttgaa gggggtgtcg agaagcccca ttctctccta tcagctaacc   4020

cattatggca acaaagggcc ctggacccac cacaccaaat ggagctgact cagtgaaaac   4080

tggaattaaa aggaaagtca agaagaatga actatgtcga tgcacagtat cttttctttc   4140

aaaagtagag caaaactata ggttttggtt ccacaatctc tacgactaat cacctactca   4200

atgcctggag acagatacgt agttgtgctt ttgtttgctc ttttaagcag tctcactgca   4260

gtcttatttc caagtaagag tactgggaga atcactaggt aacttattag aaacccaaat   4320

tgggacaaca gtgctttgta aattgtgttg tcttcagcag tcaatacaaa tagatttttg   4380

tttttgttgt tcctgcagcc ccagaagaaa ttaggggtta aagcagacag tcacactggt   4440

ttggtcagtt acaaagtaat ttctttgatc tggacagaac atttatatca gtttcatgaa   4500

atgattggaa tattacaata ccgttaagat acagtgtagg catttaactc ctcattggcg   4560

tggtccatgc tgatgatttt gcaaaatgag ttgtgatgaa tcaatgaaaa atgtaattta   4620

gaaactgatt tcttcagaat tagatggctt attttttaaa atatttgaat gaaaacattt   4680

tatttttaaa atattacaca ggaggcttcg gagtttctta gtcattactg tccttttccc   4740

ctacagaatt ttccctcttg gtgtgattgc acagaatttg tatgtatttt cagttacaag   4800

attgtaagta aattgcctga tttgttttca ttatagacaa cgatgaattt cttctaatta   4860

tttaaataaa atcaccaaaa acataaaaaa aaaaaaaaaa aaaaaaaaaa aaa          4913


<210>  179
<211>  1207
<212>  PRT
<213>  Homo sapiens

<400>  179


Met Leu Leu Thr Leu Ile Ile Leu Leu Pro Val Val Ser Lys Phe Ser 
1               5                   10                  15      


Phe Val Ser Leu Ser Ala Pro Gln His Trp Ser Cys Pro Glu Gly Thr 
            20                  25                  30          


Leu Ala Gly Asn Gly Asn Ser Thr Cys Val Gly Pro Ala Pro Phe Leu 
        35                  40                  45              


Ile Phe Ser His Gly Asn Ser Ile Phe Arg Ile Asp Thr Glu Gly Thr 
    50                  55                  60                  


Asn Tyr Glu Gln Leu Val Val Asp Ala Gly Val Ser Val Ile Met Asp 
65                  70                  75                  80  


Phe His Tyr Asn Glu Lys Arg Ile Tyr Trp Val Asp Leu Glu Arg Gln 
                85                  90                  95      


Leu Leu Gln Arg Val Phe Leu Asn Gly Ser Arg Gln Glu Arg Val Cys 
            100                 105                 110         


Asn Ile Glu Lys Asn Val Ser Gly Met Ala Ile Asn Trp Ile Asn Glu 
        115                 120                 125             


Glu Val Ile Trp Ser Asn Gln Gln Glu Gly Ile Ile Thr Val Thr Asp 
    130                 135                 140                 


Met Lys Gly Asn Asn Ser His Ile Leu Leu Ser Ala Leu Lys Tyr Pro 
145                 150                 155                 160 


Ala Asn Val Ala Val Asp Pro Val Glu Arg Phe Ile Phe Trp Ser Ser 
                165                 170                 175     


Glu Val Ala Gly Ser Leu Tyr Arg Ala Asp Leu Asp Gly Val Gly Val 
            180                 185                 190         


Lys Ala Leu Leu Glu Thr Ser Glu Lys Ile Thr Ala Val Ser Leu Asp 
        195                 200                 205             


Val Leu Asp Lys Arg Leu Phe Trp Ile Gln Tyr Asn Arg Glu Gly Ser 
    210                 215                 220                 


Asn Ser Leu Ile Cys Ser Cys Asp Tyr Asp Gly Gly Ser Val His Ile 
225                 230                 235                 240 


Ser Lys His Pro Thr Gln His Asn Leu Phe Ala Met Ser Leu Phe Gly 
                245                 250                 255     


Asp Arg Ile Phe Tyr Ser Thr Trp Lys Met Lys Thr Ile Trp Ile Ala 
            260                 265                 270         


Asn Lys His Thr Gly Lys Asp Met Val Arg Ile Asn Leu His Ser Ser 
        275                 280                 285             


Phe Val Pro Leu Gly Glu Leu Lys Val Val His Pro Leu Ala Gln Pro 
    290                 295                 300                 


Lys Ala Glu Asp Asp Thr Trp Glu Pro Glu Gln Lys Leu Cys Lys Leu 
305                 310                 315                 320 


Arg Lys Gly Asn Cys Ser Ser Thr Val Cys Gly Gln Asp Leu Gln Ser 
                325                 330                 335     


His Leu Cys Met Cys Ala Glu Gly Tyr Ala Leu Ser Arg Asp Arg Lys 
            340                 345                 350         


Tyr Cys Glu Asp Val Asn Glu Cys Ala Phe Trp Asn His Gly Cys Thr 
        355                 360                 365             


Leu Gly Cys Lys Asn Thr Pro Gly Ser Tyr Tyr Cys Thr Cys Pro Val 
    370                 375                 380                 


Gly Phe Val Leu Leu Pro Asp Gly Lys Arg Cys His Gln Leu Val Ser 
385                 390                 395                 400 


Cys Pro Arg Asn Val Ser Glu Cys Ser His Asp Cys Val Leu Thr Ser 
                405                 410                 415     


Glu Gly Pro Leu Cys Phe Cys Pro Glu Gly Ser Val Leu Glu Arg Asp 
            420                 425                 430         


Gly Lys Thr Cys Ser Gly Cys Ser Ser Pro Asp Asn Gly Gly Cys Ser 
        435                 440                 445             


Gln Leu Cys Val Pro Leu Ser Pro Val Ser Trp Glu Cys Asp Cys Phe 
    450                 455                 460                 


Pro Gly Tyr Asp Leu Gln Leu Asp Glu Lys Ser Cys Ala Ala Ser Gly 
465                 470                 475                 480 


Pro Gln Pro Phe Leu Leu Phe Ala Asn Ser Gln Asp Ile Arg His Met 
                485                 490                 495     


His Phe Asp Gly Thr Asp Tyr Gly Thr Leu Leu Ser Gln Gln Met Gly 
            500                 505                 510         


Met Val Tyr Ala Leu Asp His Asp Pro Val Glu Asn Lys Ile Tyr Phe 
        515                 520                 525             


Ala His Thr Ala Leu Lys Trp Ile Glu Arg Ala Asn Met Asp Gly Ser 
    530                 535                 540                 


Gln Arg Glu Arg Leu Ile Glu Glu Gly Val Asp Val Pro Glu Gly Leu 
545                 550                 555                 560 


Ala Val Asp Trp Ile Gly Arg Arg Phe Tyr Trp Thr Asp Arg Gly Lys 
                565                 570                 575     


Ser Leu Ile Gly Arg Ser Asp Leu Asn Gly Lys Arg Ser Lys Ile Ile 
            580                 585                 590         


Thr Lys Glu Asn Ile Ser Gln Pro Arg Gly Ile Ala Val His Pro Met 
        595                 600                 605             


Ala Lys Arg Leu Phe Trp Thr Asp Thr Gly Ile Asn Pro Arg Ile Glu 
    610                 615                 620                 


Ser Ser Ser Leu Gln Gly Leu Gly Arg Leu Val Ile Ala Ser Ser Asp 
625                 630                 635                 640 


Leu Ile Trp Pro Ser Gly Ile Thr Ile Asp Phe Leu Thr Asp Lys Leu 
                645                 650                 655     


Tyr Trp Cys Asp Ala Lys Gln Ser Val Ile Glu Met Ala Asn Leu Asp 
            660                 665                 670         


Gly Ser Lys Arg Arg Arg Leu Thr Gln Asn Asp Val Gly His Pro Phe 
        675                 680                 685             


Ala Val Ala Val Phe Glu Asp Tyr Val Trp Phe Ser Asp Trp Ala Met 
    690                 695                 700                 


Pro Ser Val Met Arg Val Asn Lys Arg Thr Gly Lys Asp Arg Val Arg 
705                 710                 715                 720 


Leu Gln Gly Ser Met Leu Lys Pro Ser Ser Leu Val Val Val His Pro 
                725                 730                 735     


Leu Ala Lys Pro Gly Ala Asp Pro Cys Leu Tyr Gln Asn Gly Gly Cys 
            740                 745                 750         


Glu His Ile Cys Lys Lys Arg Leu Gly Thr Ala Trp Cys Ser Cys Arg 
        755                 760                 765             


Glu Gly Phe Met Lys Ala Ser Asp Gly Lys Thr Cys Leu Ala Leu Asp 
    770                 775                 780                 


Gly His Gln Leu Leu Ala Gly Gly Glu Val Asp Leu Lys Asn Gln Val 
785                 790                 795                 800 


Thr Pro Leu Asp Ile Leu Ser Lys Thr Arg Val Ser Glu Asp Asn Ile 
                805                 810                 815     


Thr Glu Ser Gln His Met Leu Val Ala Glu Ile Met Val Ser Asp Gln 
            820                 825                 830         


Asp Asp Cys Ala Pro Val Gly Cys Ser Met Tyr Ala Arg Cys Ile Ser 
        835                 840                 845             


Glu Gly Glu Asp Ala Thr Cys Gln Cys Leu Lys Gly Phe Ala Gly Asp 
    850                 855                 860                 


Gly Lys Leu Cys Ser Asp Ile Asp Glu Cys Glu Met Gly Val Pro Val 
865                 870                 875                 880 


Cys Pro Pro Ala Ser Ser Lys Cys Ile Asn Thr Glu Gly Gly Tyr Val 
                885                 890                 895     


Cys Arg Cys Ser Glu Gly Tyr Gln Gly Asp Gly Ile His Cys Leu Asp 
            900                 905                 910         


Ile Asp Glu Cys Gln Leu Gly Glu His Ser Cys Gly Glu Asn Ala Ser 
        915                 920                 925             


Cys Thr Asn Thr Glu Gly Gly Tyr Thr Cys Met Cys Ala Gly Arg Leu 
    930                 935                 940                 


Ser Glu Pro Gly Leu Ile Cys Pro Asp Ser Thr Pro Pro Pro His Leu 
945                 950                 955                 960 


Arg Glu Asp Asp His His Tyr Ser Val Arg Asn Ser Asp Ser Glu Cys 
                965                 970                 975     


Pro Leu Ser His Asp Gly Tyr Cys Leu His Asp Gly Val Cys Met Tyr 
            980                 985                 990         


Ile Glu Ala Leu Asp Lys Tyr Ala  Cys Asn Cys Val Val  Gly Tyr Ile 
        995                 1000                 1005             


Gly Glu  Arg Cys Gln Tyr Arg  Asp Leu Lys Trp Trp  Glu Leu Arg 
    1010                 1015                 1020             


His Ala  Gly His Gly Gln Gln  Gln Lys Val Ile Val  Val Ala Val 
    1025                 1030                 1035             


Cys Val  Val Val Leu Val Met  Leu Leu Leu Leu Ser  Leu Trp Gly 
    1040                 1045                 1050             


Ala His  Tyr Tyr Arg Thr Gln  Lys Leu Leu Ser Lys  Asn Pro Lys 
    1055                 1060                 1065             


Asn Pro  Tyr Glu Glu Ser Ser  Arg Asp Val Arg Ser  Arg Arg Pro 
    1070                 1075                 1080             


Ala Asp  Thr Glu Asp Gly Met  Ser Ser Cys Pro Gln  Pro Trp Phe 
    1085                 1090                 1095             


Val Val  Ile Lys Glu His Gln  Asp Leu Lys Asn Gly  Gly Gln Pro 
    1100                 1105                 1110             


Val Ala  Gly Glu Asp Gly Gln  Ala Ala Asp Gly Ser  Met Gln Pro 
    1115                 1120                 1125             


Thr Ser  Trp Arg Gln Glu Pro  Gln Leu Cys Gly Met  Gly Thr Glu 
    1130                 1135                 1140             


Gln Gly  Cys Trp Ile Pro Val  Ser Ser Asp Lys Gly  Ser Cys Pro 
    1145                 1150                 1155             


Gln Val  Met Glu Arg Ser Phe  His Met Pro Ser Tyr  Gly Thr Gln 
    1160                 1165                 1170             


Thr Leu  Glu Gly Gly Val Glu  Lys Pro His Ser Leu  Leu Ser Ala 
    1175                 1180                 1185             


Asn Pro  Leu Trp Gln Gln Arg  Ala Leu Asp Pro Pro  His Gln Met 
    1190                 1195                 1200             


Glu Leu  Thr Gln 
    1205         

<210>  180
<211>  14243
<212>  DNA
<213>  Homo sapiens

<400>  180
ctcctcctcc tgctttcctc cagtaagtgc atacccgcta gtggtctgta caggcggcac     60

ggtttgatgg cagagatatt ttctttccaa actgttcaaa atgatgaacg aagatgcagc    120

tcagaaaagc gacagtggag agaagttcaa cggcagtagt cagaggagaa aaagacccaa    180

gaagtctgac agcaatgcaa gcttcctccg tgctgccaga gcaggcaacc tggacaaagt    240

tgtggaatat ctgaaggggg gcatagacat caatacctgc aatcagaatg gactcaacgc    300

tctccatctg gctgccaagg aaggccacgt ggggctggtg caggagctgc tgggaagagg    360

gtcctctgtg gattctgcca ctaagaaggg aaataccgct cttcacattg catctttggc    420

tggacaagca gaagttgtca aagttcttgt taaggaagga gccaatatta atgcacagtc    480

tcagaatggc tttactcctt tatacatggc tgcccaagag aatcacattg atgttgtaaa    540

atatttgctg gaaaatggag ctaatcagag cactgctaca gaggatggct ttactcctct    600

agctgtggca ctccagcaag gacacaacca ggcggtggcc atcctcttgg agaatgacac    660

caaagggaaa gtgaggctgc cagctctgca tattgccgct aggaaagacg acaccaaatc    720

tgccgcactt ctgcttcaga atgaccacaa tgctgacgta caatccaaga tgatggtgaa    780

taggacaact gagagtggtt ttaccccttt gcacatagct gcacattacg gaaatgtcaa    840

cgtggcaact cttcttctaa accggggagc tgctgtggac ttcacagcca ggaatggaat    900

cactcctctg catgtggctt ccaaaagagg aaatacaaac atggtgaagc tcttactgga    960

tcgaggcggt cagatcgatg ccaaaactag ggatgggttg acaccacttc actgtgctgc   1020

acgaagtggg catgaccaag tggtggaact tctgttggaa cggggtgccc ccttgctggc   1080

aaggactaag aatgggctgt ctccactaca catggctgcc cagggagacc acgtggaatg   1140

tgtgaagcac ctgttacagc acaaggcacc tgttgatgat gtcaccctag actacctgac   1200

agccctccac gttgctgcgc actgtggcca ctaccgtgta accaaactcc ttttagacaa   1260

gagagccaat ccgaacgcca gagccctgaa tggttttact ccactgcaca ttgcctgcaa   1320

gaaaaaccgc atcaaagtca tggaactgct ggtgaaatat ggggcttcaa tccaagctat   1380

aacagagtct ggcctcacac caatacatgt ggctgccttc atgggccact tgaacattgt   1440

cctccttctg ctgcagaacg gagcctctcc agatgtcact aacattcgtg gtgagacggc   1500

actacacatg gcagcccgag ccgggcaggt ggaagtggtc cgatgcctcc tgagaaatgg   1560

tgcccttgtt gatgccagag ccagggagga acagacacct ttacatattg cctcccgcct   1620

gggtaagaca gaaattgtcc agctgcttct acaacatatg gctcatccag atgcggccac   1680

tacaaatggg tacacaccac tgcacatctc tgcccgggag ggccaggtgg atgtggcatc   1740

agtcctattg gaagcaggag cagcccactc cttagctacc aagaagggtt ttactcccct   1800

gcatgtagca gccaagtatg gaagcctgga tgtggcaaaa cttctcttgc aacgccgtgc   1860

tgccgcagat tctgcaggga agaacggcct taccccgctc catgttgctg ctcattatga   1920

caaccagaag gtggcgctgc tgttactgga gaagggtgct tcccctcatg ccactgccaa   1980

gaatggctat actccgttac atattgctgc caagaagaat caaatgcaga tagcttccac   2040

actcctgaac tatggagcag agacaaacat tgtgacaaag caaggagtaa ctccactcca   2100

tctggcctcg caggaggggc acacagatat ggttaccttg cttctggata agggagccaa   2160

tatccacatg tcaactaaga gtggactcac atccttacac cttgcagccc aggaagataa   2220

agtgaatgtt gctgatattc tcaccaagca tggagctgat caggatgctc atacaaagct   2280

tggttacaca cctttaattg tggcctgtca ctatggaaat gtgaaaatgg tcaactttct   2340

tctgaagcag ggagcaaatg ttaacgcaaa aaccaagaac ggctacacgc ctttgcacca   2400

ggccgctcag cagggtcaca cgcacatcat caacgtcctg ctccagcatg gggccaagcc   2460

caacgccacc actgcgaatg gcaacactgc cttggcgatt gctaagcgtc tgggctacat   2520

ctccgtggtc gacaccctga aggttgtgac tgaggaggtc accaccacca ccacaactat   2580

tacagaaaaa cacaaactaa atgtacctga gacgatgact gaggttcttg atgtttctga   2640

tgaagagggt gatgacacaa tgactggtga tgggggagaa taccttaggc ctgaggacct   2700

aaaagaactg ggtgatgact cactacccag cagtcagttc ctggatggta tgaattacct   2760

gcgatacagc ttggagggag gacgatctga cagccttcga tccttcagtt ccgacaggtc   2820

tcacactctg agccatgcct cctacctgag ggacagtgcc gtgatggatg actcagttgt   2880

gattcccagt caccaggtgt caactctagc caaggaggca gaaaggaatt cttatcgcct   2940

aagctggggc actgagaact tagacaacgt ggctctttct tctagtccta ttcattcagg   3000

tttcctggtt agttttatgg tggatgcccg aggtggtgct atgcgaggat gcagacacaa   3060

tgggctccga atcattattc cacctcggaa atgtactgct ccaacgcgag tcacctgccg   3120

actggtcaag cgccacagac tggcaacaat gcctccaatg gtggaaggag aaggcctggc   3180

cagtcgcctg atcgaagttg gaccttctgg tgctcagttc cttggtaaac ttcacctgcc   3240

aacggctcct cccccactta atgagggaga aagtttggtc agccgcattc ttcagctggg   3300

gcctcctgga accaaattcc ttgggcctgt gatcgtggag atccctcact ttgcggccct   3360

tcgaggaaag gaaagggaac tggtggtcct gcgcagtgag aatggggaca gctggaaaga   3420

gcatttctgt gactacactg aagatgaatt gaatgaaatt cttaacggca tggatgaagt   3480

actggatagc ccagaagacc tagaaaagaa acgaatctgc cgcatcatca cccgagactt   3540

cccacagtac tttgcagtgg tgtctcgtat caaacaggac agcaatctga ttggcccaga   3600

aggaggtgta ctgagcagca cagtggtgcc ccaggtgcag gccgtcttcc cagagggggc   3660

actcaccaag cggatccgcg taggcctgca ggctcaacct atgcacagtg agctggttaa   3720

gaagatccta ggcaacaaag ctaccttcag ccctatagtc actttggaac ctagaagaag   3780

aaaattccac aaaccaatta ccatgaccat tcctgtcccc aaagcttcaa gtgatgtcat   3840

gttgaatggt tttgggggag atgcaccaac cttaagatta ctatgcagca taacaggtgg   3900

aaccacccct gcccagtggg aagatattac aggaactacg ccattaacat ttgtcaatga   3960

atgtgtttcc tttacaacaa acgtgtctgc caggttctgg ctgatagatt gtcgacagat   4020

ccaggaatcc gttacttttg catcacaagt atacagagaa attatctgcg taccttatat   4080

ggccaaattt gtagtgtttg ccaaatcaca tgaccccatt gaagccaggt tgaggtgttt   4140

ctgcatgact gatgataaag tggataagac ccttgaacaa caagaaaatt ttgctgaggt   4200

ggccagaagc agggatgtgg aggtgttaga aggaaaaccc atctacgttg attgtttcgg   4260

caacttggta ccattaacta aaagtggcca gcatcatata ttcagttttt ttgccttcaa   4320

agaaaataga cttcctctat ttgtcaaggt acgcgatacg actcaggaac cttgcggacg   4380

actatcattt atgaaggagc caaaatccac gagaggcctg gtgcatcaag ctatttgcaa   4440

cttaaacatc actttgccga tttatacaaa ggaatcagag tcagatcaag aacaggagga   4500

agagatcgat atgacatcag aaaaaaatga tgagacagaa tctacagaaa catctgtcct   4560

gaaaagtcac ctggttaatg aagttcctgt cctagcaagt ccggacttgc tctctgaagt   4620

ttctgagatg aaacaagatt tgatcaaaat gaccgccatc ttgaccacag atgtgtctga   4680

taaggcaggt tctattaaag tgaaggagct ggtgaaggct gctgaggaag agccaggaga   4740

gccttttgaa atcgttgaaa gagttaaaga ggacttagag aaagtgaatg aaatcctgag   4800

aagtggaacc tgcacaagag atgaaagcag tgtgcagagc tctcggtctg agagaggatt   4860

agttgaagag gaatgggtta ttgtcagtga tgaggaaata gaagaggcta ggcaaaaagc   4920

acctttagaa atcactgaat atccatgtgt agaagttaga atagataaag agatcaaagg   4980

aaaagtagag aaagactcaa ctgggctagt gaactacctt actgatgatc tgaatacctg   5040

tgtgcctctt cccaaagagc agctgcagac agttcaagat aaggcaggga agaaatgtga   5100

ggctctggct gttggcagga gctctgaaaa ggaagggaaa gacatacccc cagatgagac   5160

acagagtaca cagaaacagc acaaaccaag cttgggaata aagaagccag taagaaggaa   5220

attaaaagaa aagcagaaac aaaaagagga aggtttacaa gctagtgcag agaaagctga   5280

acttaaaaaa ggtagttcag aagagtcatt aggtgaagac ccaggtttag cccctgaacc   5340

ccttcccact gtcaaggcca catctccttt gatagaagaa actcccattg gttccataaa   5400

ggacaaagta aaggcccttc agaagcgagt ggaagatgaa cagaaaggtc gaagcaagtt   5460

gcccatcaga gtcaaaggca aggaggacgt gccaaaaaag accacccaca ggccacatcc   5520

agctgcgtca ccctctctga agtcagagag acatgcgcca gggtctccct cccctaaaac   5580

agaaagacac tctactcttt cctcttccgc aaaaactgaa aggcaccctc cagtatcacc   5640

atcaagtaaa actgagaaac actcacctgt gtcaccctct gcaaaaacgg aaagacattc   5700

acctgcgtca tcatcgagta aaactgagaa acactcacct gtatcaccct cgacaaaaac   5760

tgaaaggcac tctcctgtgt catctacaaa aacagaaaga cacccacctg tttcgccttc   5820

aggcaaaaca gacaaacgtc cacctgtatc gccctccggg aggacagaaa aacacccgcc   5880

agtatcgcct gggagaacag aaaaacgctt gcctgtttca ccctccggaa gaacggacaa   5940

gcaccaacct gtatcaacag ctgggaaaac tgagaagcac ctgcctgtgt caccttctgg   6000

caaaacagaa aagcaaccac ctgtatcccc cacttcaaaa acagagagga ttgaggaaac   6060

catgtctgtt cgggagctga tgaaggcttt ccagtcaggt caggaccctt ctaaacataa   6120

aactggactc tttgagcaca aatcagcaaa acaaaagcag ccacaagaga aaggtaaagt   6180

tcgggtagaa aaagaaaagg ggccgatact aacccagaga gaagctcaga aaacagagaa   6240

tcagacaatc aaacgaggcc agagactccc ggtaacgggc acagcagaat ccaaaagagg   6300

agttcgtgtt tcctccatag gagttaagaa agaagatgca gctggaggaa aggagaaagt   6360

tctcagccac aaaatacctg aacctgttca gtcagtgcct gaagaagaaa gccacagaga   6420

gagcgaagtg cccaaagaaa agatggctga tgagcaggga gacatggatc tacagatcag   6480

cccagatagg aaaacctcca ctgacttctc tgaggtcatt aagcaagagt tggaagacaa   6540

tgacaaatac caacaattcc gcctgagtga ggagacagaa aaggcacagc ttcacttaga   6600

ccaagtactc actagtcctt tcaacacaac atttccactc gactacatga aagatgagtt   6660

ccttccagct ctgtctttac aaagcggtgc tttagatggc agttctgaaa gcctaaagaa   6720

tgagggggta gccggctctc cgtgtggcag cctgatggag gggacccctc agattagttc   6780

agaagaaagc tataagcatg aaggcctagc agagacccct gagacgagcc cagaaagcct   6840

ttctttctca ccaaagaaaa gtgaggagca aactggggaa acaaaggaaa gcaccaagac   6900

agaaaccacc acagaaattc gttcagaaaa agagcatccc acgaccaaag acattactgg   6960

tggctctgaa gagcgaggtg ccacagtcac tgaggactca gagacctcta ctgagagttt   7020

tcagaaagag gccactctag gctctcccaa agacacaagc cctaaaagac aagatgattg   7080

cacaggcagc tgtagtgtag cattagctaa agagacacct acaggactga ctgaggaggc   7140

agcctgtgat gaaggtcaac gtacctttgg tagttcagcc cacaagacac aaactgatag   7200

tgaggttcaa gaatccacag ccacctcaga cgagacaaag gccttgccgc tgcctgaggc   7260

ttctgtaaag acagatacag gaactgaatc aaaacctcag ggagtcatta gaagtcccca   7320

agggttagaa cttgcactcc ctagccgaga tagcgaagtc ctcagcgctg tggctgatga   7380

ctcattagca gtgagccaca aagactctct ggaagccagc cctgtgctag aagataactc   7440

ttcacacaaa acccctgatt ctctggagcc aagtcctctg aaagaatccc cttgccgtga   7500

ctctctggaa agcagccctg ttgaaccaaa gatgaaggct ggaatttttc caagtcactt   7560

tcctcttcct gcagctgttg ccaaaacaga actcttgacg gaagtggcct ctgtgcggtc   7620

ccggctactc cgagaccctg atggcagtgc tgaggatgac agtcttgagc agacatcgct   7680

catggagagc tcagggaaga gccccctttc tcctgacacc cccagctctg aagaagtcag   7740

ctatgaggtt acacccaaaa ccacagatgt aagtacacca aaaccagctg tgattcatga   7800

atgtgcagag gaggatgatt cagaaaacgg ggagaaaaag aggttcacac ctgaagagga   7860

gatgtttaaa atggtaacca aaatcaaaat gtttgatgaa cttgaacaag aagcaaagca   7920

gaaaagggac tacaaaaaag aacccaaaca agaagaatct tcttcatctt ctgacccaga   7980

tgctgactgt tcagtagatg tggatgaacc aaaacataca ggcagtgggg aggatgaaag   8040

tggtgtccct gtgttagtaa cttcggagag caggaaggtg tcttcctcct cagaaagtga   8100

acctgagttg gcacagctta aaaaaggtgc tgactcaggc cttttaccag aaccagtgat   8160

tcgagtacaa cctccttctc cacttccatc aagcatggac tccaattcca gtccagaaga   8220

agtacaattc cagcctgtcg tttccaaaca atatactttc aagatgaatg aagatactca   8280

ggaagagcca ggcaaatcag aagaagaaaa agattctgaa tcccatttag ctgaagaccg   8340

tcatgctgtt tccactgagg ctgaagacag gtcttatgat aagctaaaca gagacactga   8400

tcagccaaaa atctgtgatg gccatggatg tgaggccatg agtcctagca gctcagctgc   8460

tcctgtctct tcaggtctac agagtccgac tggtgatgat gttgatgaac agccagtcat   8520

ctataaagaa tcattagctc tccaaggcac tcatgaaaaa gacacagagg gagaagagct   8580

tgatgtttct agagcagaat ctccacaagc agattgcccc agtgaaagct tttcatcttc   8640

atcctctttg cctcattgtt tggtatctga aggaaaagaa ttagatgaag acatatctgc   8700

cacatcttct attcaaaaaa cagaggtcac aaaaactgat gaaacatttg agaacttacc   8760

aaaggactgc ccctctcaag actcatccat tactactcaa acagatagat tttccatgga   8820

tgttcccgtg tctgacctag ctgagaatga tgaaatctat gatccacaaa tcactagccc   8880

ttatgaaaat gtcccttccc aatctttttt ctctagtgaa gaaagcaaaa cccaaacaga   8940

tgcaaatcac accacaagtt ttcactcttc tgaagtgtat tctgttacca tcacatcccc   9000

tgttgaagac gttgtagtgg caagctcctc tagtggaact gttttaagca aagaatctaa   9060

ttttgagggc caggacataa aaatggaatc ccaacaggaa agtaccttgt gggaaatgca   9120

atcagacagt gtctcttcat ctttcgagcc tactatgtcc gctacaacaa cagttgttgg   9180

tgaacaaata agcaaagtca tcatcacaaa aactgatgtg gattctgatt cttggagtga   9240

aattcgggaa gacgatgaag cctttgaggc tcgtgtgaaa gaggaagaac aaaagatatt   9300

tggtttgatg gtagacagac aatcacaggg taccacccct gacaccactc ctgctaggac   9360

cccaactgaa gaggggaccc caacaagtga gcaaaaccca tttctgtttc aggaaggaaa   9420

attgtttgaa atgacccgaa gtggtgccat tgatatgacc aaaaggtcct atgcagatga   9480

aagttttcac tttttccaaa ttggtcaaga atccagggaa gagactctct ctgaagatgt   9540

gaaagaaggg gctactgggg ctgatcccct accgctggag acatcagctg aatcactagc   9600

actttcagaa tcaaaagaaa cagtggatga tgaggcagac ttacttccag atgacgtgag   9660

tgaggaagta gaggaaatac ctgcttcgga tgctcaactt aactcccaaa tggggatttc   9720

agcctccact gaaacaccta caaaagaagc tgttagtgta gggaccaagg acctccccac   9780

cgtgcaaacg ggtgatatac ctcctctctc tggtgtaaag cagatatcct gccccgactc   9840

ttctgaacca gctgtacaag tccagttaga tttttccaca ctcaccaggt ctgtttattc   9900

agataggggt gatgattctc ccgattcttc cccagaagaa cagaaatcag taatcgagat   9960

tcctactgca cccatggaga atgtgccttt tactgaaagc aaatccaaaa ttcctgtaag  10020

gactatgccc acttccaccc cagcacctcc atctgcagag tatgagagtt cagtttctga  10080

agattttcta tccagtgtag atgaggaaaa taaggcggat gaagcaaaac caaagtccaa  10140

actccctgtc aaagtacccc tccaaagagt tgaacagcag ctctcagatc tagacacctc  10200

tgtccagaag acagtggctc ctcagggaca ggacatggca agcatcgcac cagataatag  10260

aagcaaatct gaatctgatg ctagttcttt ggattcaaag accaaatgcc cagtaaaaac  10320

ccgaagttac actgagacag aaacagagag cagagagagg gccgaggaac ttgagttaga  10380

atcagaagaa ggggccacaa gaccaaagat acttacatcc cgattgccag ttaagagcag  10440

aagcactaca tcttcctgca gggggggcac gagccccaca aaagaaagta aggagcattt  10500

ctttgacctt tacagaaatt ccatagaatt ctttgaggag attagtgatg aggcttccaa  10560

attagtggat aggctgacac agtcagagag ggagcaggaa atagtttcag acgatgaaag  10620

tagtagtgcc ctggaagtat cagtaattga aaatctgcca cctgttgaga ccgagcactc  10680

agttcctgag gacatctttg acacaaggcc catttgggat gagtctattg agactctgat  10740

tgaacgcatc cctgatgaaa atggccatga ccatgctgaa gatccacagg atgagcagga  10800

acggatcgag gaaaggctgg cttatattgc tgatcacctt ggcttcagct ggacagaatt  10860

agcaagagaa ctggatttca ctgaggagca aattcatcaa attcgaattg aaaatcccaa  10920

ctctcttcaa gaccagagtc atgcactgtt gaagtactgg ctagagaggg atgggaaaca  10980

tgctacagat accaacctcg ttgaatgtct caccaagatc aaccgaatgg atattgttca  11040

tctcatggag accaacacag aacctctcca ggagcgcatc agtcatagtt atgcagaaat  11100

tgaacagacc attacactgg atcatagtga agggttctcg gtacttcaag aggagttatg  11160

cactgcacag cacaagcaga aagaggagca agctgtttct aaagaaagtg agacctgcga  11220

tcaccctcct atcgtctcag aggaagacat ttctgttggt tattccactt ttcaggatgg  11280

cgtccccaaa actgaggggg acagctcagc aacagcactc tttccccaaa ctcacaagga  11340

gcaagttcaa caggatttct cagggaaaat gcaagacctg cctgaagagt catctctgga  11400

atatcagcag gaatattttg tgacaactcc aggaacagaa acatcagaga ctcagaaggc  11460

tatgatagta cccagctctc ccagcaagac acctgaggaa gttagcaccc ctgcagagga  11520

ggagaagctg tacctccaga ccccaacatc cagcgagcgg ggaggctctc ccatcataca  11580

agaacccgaa gagccctcag agcacagaga ggagagctct ccgcggaaaa ccagcctcgt  11640

aatagtggag tctgccgata accagcctga gacctgtgaa agactcgatg aagatgcagc  11700

ttttgaaaag ggagacgata tgcctgaaat acccccagaa acagtcacag aagaagaata  11760

cattgatgag catggacaca ccgtggtaaa gaaggttact aggaaaatca ttaggcggta  11820

tgtatcctct gaaggcacag agaaagaaga gattatggtg cagggaatgc cacaggaacc  11880

tgtcaacatc gaggaagggg atggctattc caaagttata aagcgtgttg tattgaagag  11940

tgacaccgag cagtcagagg acaacaatga gtaaagccat cacacagaag agggctgtgg  12000

tgaaggacca gcatggaaaa cgcattgact tggagcacct ggaggatgta ccagaagcac  12060

tagaccagga cgacctccag cgcgatctcc agcagctcct tcggcatttc tgcaaggagg  12120

acttgaagca agaggccaag tgaggggctg cccagttctc acaccagaaa ccacacattc  12180

actcaatatg cagcttcctg tttcagtagg ggagtgacct aactggccta attaatggga  12240

taccccgaca tttccactgt tagcaaatat acggcatttt gctttagttt tcccccatcc  12300

tctttaacta taaagctaat ttgtgaccaa agatggcatc cttcatactg gatgctgtat  12360

ccaatacttt gttgtgtctg tgctaacctg ggaactggcc acctccattg ttctttgctt  12420

ctgcacaaga tccatgaaaa tccattgatc agaagaactt cacctgcaga cctcttcaag  12480

tgacactatg taggaatcct tccaaggaat atctatgtac aatgtatata gctgaaatgc  12540

tcagatgaac aacatattaa aattaaaacc actgcctatt gtaactacac tgggcatcag  12600

aataaaaggc ctctagaaat tgctgaacaa tggttaatta agatattgct aacacaatcg  12660

agtgataata cagttttact gcaaaagaag cacttcaaac ctattatgtc cttagaactt  12720

ccagagtagc cactgctccc agttaaaggt gggtcagtag ccttgcagaa ctgtcctgag  12780

aagttattgc tggtgctggc cagccatggc ttaggactcc aacagccact ctgagggagg  12840

ggagaaggga gcagaggcca cgcagaatga accgatgggg tattcagttg ctggcagcta  12900

cattgtgtgg cattctagca tcttcaggtc tttagatctt ggacaagttg gcagggtatt  12960

ttaaaagcta taactactgt agttttccag ttttcattgc tgctttagca aaccacgctg  13020

tcttacagtg gtactttctt ctggccactg cactgtagat aattcattgg aaacaagatt  13080

tacccactac ataaaaggtt aaactccttc agtatgttgg agtggtttct tttttttttt  13140

ctttctttct tttttttctt caggtttata tcttctctaa tacctgcatg tggcgtttaa  13200

aaatcaagac cacggtcaaa cccctcttct aatcacatta attgtttcca ttctttttac  13260

cctgagtgag cacttttcac tttccagcta ggtctgtttt tcagcttgca gacaagattg  13320

agaaatcctt gaaaatttgg ttttggttaa aatttttggt ttatttattt gaaatccaca  13380

ctcccttgga aactcttaag tgcatttgtg cacttctgtt tgtttgtctc aaagaaggga  13440

ctgtaacaat ctgagtaatt tccatgtcct cttccttatt cctctagtgg ttgaagctgt  13500

gtagcatttt aacatatata tattcacaaa tatattcata taaacagtat acattttgaa  13560

tcagtcattt gttaaagaaa agtatattca atgaagatga aatttaaata aaaaaggaca  13620

gagtctatcc tccagggatt gaacattttc caattatctg gtcttttcct gttgtgcaaa  13680

aatgactcat tgctccgaat gtcaaaaaca aatgcgacaa acaatggcac ttcatcattt  13740

aaagtaatgt tgccaagaga aaaaatttcc tgggagggag gtttcccaca agccaaatct  13800

cctaagcctc aaatgctagc actttttggc agttggatag gaaatgagac attctttggc  13860

agccaaaata agagaggccg atggtgaaac tttttgagac accctatggc cttcttgtca  13920

aaaccttcac tggagctcaa gaaaagcatt tctgttgtgt tatttgcagt gcagatgatg  13980

tctgtgtaac aacataatgg ttattcacct ttttttgatt ttgatttttg ctgtgttatc  14040

aaaaacttga atactgtgag aagaagtgaa ttttcagttg acgaatcagc atcttgttcc  14100

catggtgata acactaattg aatatatcta tgagggcatg tattagttaa tggaaaaaaa  14160

aatacaacac taacaataca tagctgcaat gtgtacaatg gctgatttaa ttaaataaaa  14220

tgtacaagtg ttaaatgtgg caa                                          14243


<210>  181
<211>  3957
<212>  PRT
<213>  Homo sapiens

<400>  181


Met Met Asn Glu Asp Ala Ala Gln Lys Ser Asp Ser Gly Glu Lys Phe 
1               5                   10                  15      


Asn Gly Ser Ser Gln Arg Arg Lys Arg Pro Lys Lys Ser Asp Ser Asn 
            20                  25                  30          


Ala Ser Phe Leu Arg Ala Ala Arg Ala Gly Asn Leu Asp Lys Val Val 
        35                  40                  45              


Glu Tyr Leu Lys Gly Gly Ile Asp Ile Asn Thr Cys Asn Gln Asn Gly 
    50                  55                  60                  


Leu Asn Ala Leu His Leu Ala Ala Lys Glu Gly His Val Gly Leu Val 
65                  70                  75                  80  


Gln Glu Leu Leu Gly Arg Gly Ser Ser Val Asp Ser Ala Thr Lys Lys 
                85                  90                  95      


Gly Asn Thr Ala Leu His Ile Ala Ser Leu Ala Gly Gln Ala Glu Val 
            100                 105                 110         


Val Lys Val Leu Val Lys Glu Gly Ala Asn Ile Asn Ala Gln Ser Gln 
        115                 120                 125             


Asn Gly Phe Thr Pro Leu Tyr Met Ala Ala Gln Glu Asn His Ile Asp 
    130                 135                 140                 


Val Val Lys Tyr Leu Leu Glu Asn Gly Ala Asn Gln Ser Thr Ala Thr 
145                 150                 155                 160 


Glu Asp Gly Phe Thr Pro Leu Ala Val Ala Leu Gln Gln Gly His Asn 
                165                 170                 175     


Gln Ala Val Ala Ile Leu Leu Glu Asn Asp Thr Lys Gly Lys Val Arg 
            180                 185                 190         


Leu Pro Ala Leu His Ile Ala Ala Arg Lys Asp Asp Thr Lys Ser Ala 
        195                 200                 205             


Ala Leu Leu Leu Gln Asn Asp His Asn Ala Asp Val Gln Ser Lys Met 
    210                 215                 220                 


Met Val Asn Arg Thr Thr Glu Ser Gly Phe Thr Pro Leu His Ile Ala 
225                 230                 235                 240 


Ala His Tyr Gly Asn Val Asn Val Ala Thr Leu Leu Leu Asn Arg Gly 
                245                 250                 255     


Ala Ala Val Asp Phe Thr Ala Arg Asn Gly Ile Thr Pro Leu His Val 
            260                 265                 270         


Ala Ser Lys Arg Gly Asn Thr Asn Met Val Lys Leu Leu Leu Asp Arg 
        275                 280                 285             


Gly Gly Gln Ile Asp Ala Lys Thr Arg Asp Gly Leu Thr Pro Leu His 
    290                 295                 300                 


Cys Ala Ala Arg Ser Gly His Asp Gln Val Val Glu Leu Leu Leu Glu 
305                 310                 315                 320 


Arg Gly Ala Pro Leu Leu Ala Arg Thr Lys Asn Gly Leu Ser Pro Leu 
                325                 330                 335     


His Met Ala Ala Gln Gly Asp His Val Glu Cys Val Lys His Leu Leu 
            340                 345                 350         


Gln His Lys Ala Pro Val Asp Asp Val Thr Leu Asp Tyr Leu Thr Ala 
        355                 360                 365             


Leu His Val Ala Ala His Cys Gly His Tyr Arg Val Thr Lys Leu Leu 
    370                 375                 380                 


Leu Asp Lys Arg Ala Asn Pro Asn Ala Arg Ala Leu Asn Gly Phe Thr 
385                 390                 395                 400 


Pro Leu His Ile Ala Cys Lys Lys Asn Arg Ile Lys Val Met Glu Leu 
                405                 410                 415     


Leu Val Lys Tyr Gly Ala Ser Ile Gln Ala Ile Thr Glu Ser Gly Leu 
            420                 425                 430         


Thr Pro Ile His Val Ala Ala Phe Met Gly His Leu Asn Ile Val Leu 
        435                 440                 445             


Leu Leu Leu Gln Asn Gly Ala Ser Pro Asp Val Thr Asn Ile Arg Gly 
    450                 455                 460                 


Glu Thr Ala Leu His Met Ala Ala Arg Ala Gly Gln Val Glu Val Val 
465                 470                 475                 480 


Arg Cys Leu Leu Arg Asn Gly Ala Leu Val Asp Ala Arg Ala Arg Glu 
                485                 490                 495     


Glu Gln Thr Pro Leu His Ile Ala Ser Arg Leu Gly Lys Thr Glu Ile 
            500                 505                 510         


Val Gln Leu Leu Leu Gln His Met Ala His Pro Asp Ala Ala Thr Thr 
        515                 520                 525             


Asn Gly Tyr Thr Pro Leu His Ile Ser Ala Arg Glu Gly Gln Val Asp 
    530                 535                 540                 


Val Ala Ser Val Leu Leu Glu Ala Gly Ala Ala His Ser Leu Ala Thr 
545                 550                 555                 560 


Lys Lys Gly Phe Thr Pro Leu His Val Ala Ala Lys Tyr Gly Ser Leu 
                565                 570                 575     


Asp Val Ala Lys Leu Leu Leu Gln Arg Arg Ala Ala Ala Asp Ser Ala 
            580                 585                 590         


Gly Lys Asn Gly Leu Thr Pro Leu His Val Ala Ala His Tyr Asp Asn 
        595                 600                 605             


Gln Lys Val Ala Leu Leu Leu Leu Glu Lys Gly Ala Ser Pro His Ala 
    610                 615                 620                 


Thr Ala Lys Asn Gly Tyr Thr Pro Leu His Ile Ala Ala Lys Lys Asn 
625                 630                 635                 640 


Gln Met Gln Ile Ala Ser Thr Leu Leu Asn Tyr Gly Ala Glu Thr Asn 
                645                 650                 655     


Ile Val Thr Lys Gln Gly Val Thr Pro Leu His Leu Ala Ser Gln Glu 
            660                 665                 670         


Gly His Thr Asp Met Val Thr Leu Leu Leu Asp Lys Gly Ala Asn Ile 
        675                 680                 685             


His Met Ser Thr Lys Ser Gly Leu Thr Ser Leu His Leu Ala Ala Gln 
    690                 695                 700                 


Glu Asp Lys Val Asn Val Ala Asp Ile Leu Thr Lys His Gly Ala Asp 
705                 710                 715                 720 


Gln Asp Ala His Thr Lys Leu Gly Tyr Thr Pro Leu Ile Val Ala Cys 
                725                 730                 735     


His Tyr Gly Asn Val Lys Met Val Asn Phe Leu Leu Lys Gln Gly Ala 
            740                 745                 750         


Asn Val Asn Ala Lys Thr Lys Asn Gly Tyr Thr Pro Leu His Gln Ala 
        755                 760                 765             


Ala Gln Gln Gly His Thr His Ile Ile Asn Val Leu Leu Gln His Gly 
    770                 775                 780                 


Ala Lys Pro Asn Ala Thr Thr Ala Asn Gly Asn Thr Ala Leu Ala Ile 
785                 790                 795                 800 


Ala Lys Arg Leu Gly Tyr Ile Ser Val Val Asp Thr Leu Lys Val Val 
                805                 810                 815     


Thr Glu Glu Val Thr Thr Thr Thr Thr Thr Ile Thr Glu Lys His Lys 
            820                 825                 830         


Leu Asn Val Pro Glu Thr Met Thr Glu Val Leu Asp Val Ser Asp Glu 
        835                 840                 845             


Glu Gly Asp Asp Thr Met Thr Gly Asp Gly Gly Glu Tyr Leu Arg Pro 
    850                 855                 860                 


Glu Asp Leu Lys Glu Leu Gly Asp Asp Ser Leu Pro Ser Ser Gln Phe 
865                 870                 875                 880 


Leu Asp Gly Met Asn Tyr Leu Arg Tyr Ser Leu Glu Gly Gly Arg Ser 
                885                 890                 895     


Asp Ser Leu Arg Ser Phe Ser Ser Asp Arg Ser His Thr Leu Ser His 
            900                 905                 910         


Ala Ser Tyr Leu Arg Asp Ser Ala Val Met Asp Asp Ser Val Val Ile 
        915                 920                 925             


Pro Ser His Gln Val Ser Thr Leu Ala Lys Glu Ala Glu Arg Asn Ser 
    930                 935                 940                 


Tyr Arg Leu Ser Trp Gly Thr Glu Asn Leu Asp Asn Val Ala Leu Ser 
945                 950                 955                 960 


Ser Ser Pro Ile His Ser Gly Phe Leu Val Ser Phe Met Val Asp Ala 
                965                 970                 975     


Arg Gly Gly Ala Met Arg Gly Cys Arg His Asn Gly Leu Arg Ile Ile 
            980                 985                 990         


Ile Pro Pro Arg Lys Cys Thr Ala  Pro Thr Arg Val Thr  Cys Arg Leu 
        995                 1000                 1005             


Val Lys  Arg His Arg Leu Ala  Thr Met Pro Pro Met  Val Glu Gly 
    1010                 1015                 1020             


Glu Gly  Leu Ala Ser Arg Leu  Ile Glu Val Gly Pro  Ser Gly Ala 
    1025                 1030                 1035             


Gln Phe  Leu Gly Lys Leu His  Leu Pro Thr Ala Pro  Pro Pro Leu 
    1040                 1045                 1050             


Asn Glu  Gly Glu Ser Leu Val  Ser Arg Ile Leu Gln  Leu Gly Pro 
    1055                 1060                 1065             


Pro Gly  Thr Lys Phe Leu Gly  Pro Val Ile Val Glu  Ile Pro His 
    1070                 1075                 1080             


Phe Ala  Ala Leu Arg Gly Lys  Glu Arg Glu Leu Val  Val Leu Arg 
    1085                 1090                 1095             


Ser Glu  Asn Gly Asp Ser Trp  Lys Glu His Phe Cys  Asp Tyr Thr 
    1100                 1105                 1110             


Glu Asp  Glu Leu Asn Glu Ile  Leu Asn Gly Met Asp  Glu Val Leu 
    1115                 1120                 1125             


Asp Ser  Pro Glu Asp Leu Glu  Lys Lys Arg Ile Cys  Arg Ile Ile 
    1130                 1135                 1140             


Thr Arg  Asp Phe Pro Gln Tyr  Phe Ala Val Val Ser  Arg Ile Lys 
    1145                 1150                 1155             


Gln Asp  Ser Asn Leu Ile Gly  Pro Glu Gly Gly Val  Leu Ser Ser 
    1160                 1165                 1170             


Thr Val  Val Pro Gln Val Gln  Ala Val Phe Pro Glu  Gly Ala Leu 
    1175                 1180                 1185             


Thr Lys  Arg Ile Arg Val Gly  Leu Gln Ala Gln Pro  Met His Ser 
    1190                 1195                 1200             


Glu Leu  Val Lys Lys Ile Leu  Gly Asn Lys Ala Thr  Phe Ser Pro 
    1205                 1210                 1215             


Ile Val  Thr Leu Glu Pro Arg  Arg Arg Lys Phe His  Lys Pro Ile 
    1220                 1225                 1230             


Thr Met  Thr Ile Pro Val Pro  Lys Ala Ser Ser Asp  Val Met Leu 
    1235                 1240                 1245             


Asn Gly  Phe Gly Gly Asp Ala  Pro Thr Leu Arg Leu  Leu Cys Ser 
    1250                 1255                 1260             


Ile Thr  Gly Gly Thr Thr Pro  Ala Gln Trp Glu Asp  Ile Thr Gly 
    1265                 1270                 1275             


Thr Thr  Pro Leu Thr Phe Val  Asn Glu Cys Val Ser  Phe Thr Thr 
    1280                 1285                 1290             


Asn Val  Ser Ala Arg Phe Trp  Leu Ile Asp Cys Arg  Gln Ile Gln 
    1295                 1300                 1305             


Glu Ser  Val Thr Phe Ala Ser  Gln Val Tyr Arg Glu  Ile Ile Cys 
    1310                 1315                 1320             


Val Pro  Tyr Met Ala Lys Phe  Val Val Phe Ala Lys  Ser His Asp 
    1325                 1330                 1335             


Pro Ile  Glu Ala Arg Leu Arg  Cys Phe Cys Met Thr  Asp Asp Lys 
    1340                 1345                 1350             


Val Asp  Lys Thr Leu Glu Gln  Gln Glu Asn Phe Ala  Glu Val Ala 
    1355                 1360                 1365             


Arg Ser  Arg Asp Val Glu Val  Leu Glu Gly Lys Pro  Ile Tyr Val 
    1370                 1375                 1380             


Asp Cys  Phe Gly Asn Leu Val  Pro Leu Thr Lys Ser  Gly Gln His 
    1385                 1390                 1395             


His Ile  Phe Ser Phe Phe Ala  Phe Lys Glu Asn Arg  Leu Pro Leu 
    1400                 1405                 1410             


Phe Val  Lys Val Arg Asp Thr  Thr Gln Glu Pro Cys  Gly Arg Leu 
    1415                 1420                 1425             


Ser Phe  Met Lys Glu Pro Lys  Ser Thr Arg Gly Leu  Val His Gln 
    1430                 1435                 1440             


Ala Ile  Cys Asn Leu Asn Ile  Thr Leu Pro Ile Tyr  Thr Lys Glu 
    1445                 1450                 1455             


Ser Glu  Ser Asp Gln Glu Gln  Glu Glu Glu Ile Asp  Met Thr Ser 
    1460                 1465                 1470             


Glu Lys  Asn Asp Glu Thr Glu  Ser Thr Glu Thr Ser  Val Leu Lys 
    1475                 1480                 1485             


Ser His  Leu Val Asn Glu Val  Pro Val Leu Ala Ser  Pro Asp Leu 
    1490                 1495                 1500             


Leu Ser  Glu Val Ser Glu Met  Lys Gln Asp Leu Ile  Lys Met Thr 
    1505                 1510                 1515             


Ala Ile  Leu Thr Thr Asp Val  Ser Asp Lys Ala Gly  Ser Ile Lys 
    1520                 1525                 1530             


Val Lys  Glu Leu Val Lys Ala  Ala Glu Glu Glu Pro  Gly Glu Pro 
    1535                 1540                 1545             


Phe Glu  Ile Val Glu Arg Val  Lys Glu Asp Leu Glu  Lys Val Asn 
    1550                 1555                 1560             


Glu Ile  Leu Arg Ser Gly Thr  Cys Thr Arg Asp Glu  Ser Ser Val 
    1565                 1570                 1575             


Gln Ser  Ser Arg Ser Glu Arg  Gly Leu Val Glu Glu  Glu Trp Val 
    1580                 1585                 1590             


Ile Val  Ser Asp Glu Glu Ile  Glu Glu Ala Arg Gln  Lys Ala Pro 
    1595                 1600                 1605             


Leu Glu  Ile Thr Glu Tyr Pro  Cys Val Glu Val Arg  Ile Asp Lys 
    1610                 1615                 1620             


Glu Ile  Lys Gly Lys Val Glu  Lys Asp Ser Thr Gly  Leu Val Asn 
    1625                 1630                 1635             


Tyr Leu  Thr Asp Asp Leu Asn  Thr Cys Val Pro Leu  Pro Lys Glu 
    1640                 1645                 1650             


Gln Leu  Gln Thr Val Gln Asp  Lys Ala Gly Lys Lys  Cys Glu Ala 
    1655                 1660                 1665             


Leu Ala  Val Gly Arg Ser Ser  Glu Lys Glu Gly Lys  Asp Ile Pro 
    1670                 1675                 1680             


Pro Asp  Glu Thr Gln Ser Thr  Gln Lys Gln His Lys  Pro Ser Leu 
    1685                 1690                 1695             


Gly Ile  Lys Lys Pro Val Arg  Arg Lys Leu Lys Glu  Lys Gln Lys 
    1700                 1705                 1710             


Gln Lys  Glu Glu Gly Leu Gln  Ala Ser Ala Glu Lys  Ala Glu Leu 
    1715                 1720                 1725             


Lys Lys  Gly Ser Ser Glu Glu  Ser Leu Gly Glu Asp  Pro Gly Leu 
    1730                 1735                 1740             


Ala Pro  Glu Pro Leu Pro Thr  Val Lys Ala Thr Ser  Pro Leu Ile 
    1745                 1750                 1755             


Glu Glu  Thr Pro Ile Gly Ser  Ile Lys Asp Lys Val  Lys Ala Leu 
    1760                 1765                 1770             


Gln Lys  Arg Val Glu Asp Glu  Gln Lys Gly Arg Ser  Lys Leu Pro 
    1775                 1780                 1785             


Ile Arg  Val Lys Gly Lys Glu  Asp Val Pro Lys Lys  Thr Thr His 
    1790                 1795                 1800             


Arg Pro  His Pro Ala Ala Ser  Pro Ser Leu Lys Ser  Glu Arg His 
    1805                 1810                 1815             


Ala Pro  Gly Ser Pro Ser Pro  Lys Thr Glu Arg His  Ser Thr Leu 
    1820                 1825                 1830             


Ser Ser  Ser Ala Lys Thr Glu  Arg His Pro Pro Val  Ser Pro Ser 
    1835                 1840                 1845             


Ser Lys  Thr Glu Lys His Ser  Pro Val Ser Pro Ser  Ala Lys Thr 
    1850                 1855                 1860             


Glu Arg  His Ser Pro Ala Ser  Ser Ser Ser Lys Thr  Glu Lys His 
    1865                 1870                 1875             


Ser Pro  Val Ser Pro Ser Thr  Lys Thr Glu Arg His  Ser Pro Val 
    1880                 1885                 1890             


Ser Ser  Thr Lys Thr Glu Arg  His Pro Pro Val Ser  Pro Ser Gly 
    1895                 1900                 1905             


Lys Thr  Asp Lys Arg Pro Pro  Val Ser Pro Ser Gly  Arg Thr Glu 
    1910                 1915                 1920             


Lys His  Pro Pro Val Ser Pro  Gly Arg Thr Glu Lys  Arg Leu Pro 
    1925                 1930                 1935             


Val Ser  Pro Ser Gly Arg Thr  Asp Lys His Gln Pro  Val Ser Thr 
    1940                 1945                 1950             


Ala Gly  Lys Thr Glu Lys His  Leu Pro Val Ser Pro  Ser Gly Lys 
    1955                 1960                 1965             


Thr Glu  Lys Gln Pro Pro Val  Ser Pro Thr Ser Lys  Thr Glu Arg 
    1970                 1975                 1980             


Ile Glu  Glu Thr Met Ser Val  Arg Glu Leu Met Lys  Ala Phe Gln 
    1985                 1990                 1995             


Ser Gly  Gln Asp Pro Ser Lys  His Lys Thr Gly Leu  Phe Glu His 
    2000                 2005                 2010             


Lys Ser  Ala Lys Gln Lys Gln  Pro Gln Glu Lys Gly  Lys Val Arg 
    2015                 2020                 2025             


Val Glu  Lys Glu Lys Gly Pro  Ile Leu Thr Gln Arg  Glu Ala Gln 
    2030                 2035                 2040             


Lys Thr  Glu Asn Gln Thr Ile  Lys Arg Gly Gln Arg  Leu Pro Val 
    2045                 2050                 2055             


Thr Gly  Thr Ala Glu Ser Lys  Arg Gly Val Arg Val  Ser Ser Ile 
    2060                 2065                 2070             


Gly Val  Lys Lys Glu Asp Ala  Ala Gly Gly Lys Glu  Lys Val Leu 
    2075                 2080                 2085             


Ser His  Lys Ile Pro Glu Pro  Val Gln Ser Val Pro  Glu Glu Glu 
    2090                 2095                 2100             


Ser His  Arg Glu Ser Glu Val  Pro Lys Glu Lys Met  Ala Asp Glu 
    2105                 2110                 2115             


Gln Gly  Asp Met Asp Leu Gln  Ile Ser Pro Asp Arg  Lys Thr Ser 
    2120                 2125                 2130             


Thr Asp  Phe Ser Glu Val Ile  Lys Gln Glu Leu Glu  Asp Asn Asp 
    2135                 2140                 2145             


Lys Tyr  Gln Gln Phe Arg Leu  Ser Glu Glu Thr Glu  Lys Ala Gln 
    2150                 2155                 2160             


Leu His  Leu Asp Gln Val Leu  Thr Ser Pro Phe Asn  Thr Thr Phe 
    2165                 2170                 2175             


Pro Leu  Asp Tyr Met Lys Asp  Glu Phe Leu Pro Ala  Leu Ser Leu 
    2180                 2185                 2190             


Gln Ser  Gly Ala Leu Asp Gly  Ser Ser Glu Ser Leu  Lys Asn Glu 
    2195                 2200                 2205             


Gly Val  Ala Gly Ser Pro Cys  Gly Ser Leu Met Glu  Gly Thr Pro 
    2210                 2215                 2220             


Gln Ile  Ser Ser Glu Glu Ser  Tyr Lys His Glu Gly  Leu Ala Glu 
    2225                 2230                 2235             


Thr Pro  Glu Thr Ser Pro Glu  Ser Leu Ser Phe Ser  Pro Lys Lys 
    2240                 2245                 2250             


Ser Glu  Glu Gln Thr Gly Glu  Thr Lys Glu Ser Thr  Lys Thr Glu 
    2255                 2260                 2265             


Thr Thr  Thr Glu Ile Arg Ser  Glu Lys Glu His Pro  Thr Thr Lys 
    2270                 2275                 2280             


Asp Ile  Thr Gly Gly Ser Glu  Glu Arg Gly Ala Thr  Val Thr Glu 
    2285                 2290                 2295             


Asp Ser  Glu Thr Ser Thr Glu  Ser Phe Gln Lys Glu  Ala Thr Leu 
    2300                 2305                 2310             


Gly Ser  Pro Lys Asp Thr Ser  Pro Lys Arg Gln Asp  Asp Cys Thr 
    2315                 2320                 2325             


Gly Ser  Cys Ser Val Ala Leu  Ala Lys Glu Thr Pro  Thr Gly Leu 
    2330                 2335                 2340             


Thr Glu  Glu Ala Ala Cys Asp  Glu Gly Gln Arg Thr  Phe Gly Ser 
    2345                 2350                 2355             


Ser Ala  His Lys Thr Gln Thr  Asp Ser Glu Val Gln  Glu Ser Thr 
    2360                 2365                 2370             


Ala Thr  Ser Asp Glu Thr Lys  Ala Leu Pro Leu Pro  Glu Ala Ser 
    2375                 2380                 2385             


Val Lys  Thr Asp Thr Gly Thr  Glu Ser Lys Pro Gln  Gly Val Ile 
    2390                 2395                 2400             


Arg Ser  Pro Gln Gly Leu Glu  Leu Ala Leu Pro Ser  Arg Asp Ser 
    2405                 2410                 2415             


Glu Val  Leu Ser Ala Val Ala  Asp Asp Ser Leu Ala  Val Ser His 
    2420                 2425                 2430             


Lys Asp  Ser Leu Glu Ala Ser  Pro Val Leu Glu Asp  Asn Ser Ser 
    2435                 2440                 2445             


His Lys  Thr Pro Asp Ser Leu  Glu Pro Ser Pro Leu  Lys Glu Ser 
    2450                 2455                 2460             


Pro Cys  Arg Asp Ser Leu Glu  Ser Ser Pro Val Glu  Pro Lys Met 
    2465                 2470                 2475             


Lys Ala  Gly Ile Phe Pro Ser  His Phe Pro Leu Pro  Ala Ala Val 
    2480                 2485                 2490             


Ala Lys  Thr Glu Leu Leu Thr  Glu Val Ala Ser Val  Arg Ser Arg 
    2495                 2500                 2505             


Leu Leu  Arg Asp Pro Asp Gly  Ser Ala Glu Asp Asp  Ser Leu Glu 
    2510                 2515                 2520             


Gln Thr  Ser Leu Met Glu Ser  Ser Gly Lys Ser Pro  Leu Ser Pro 
    2525                 2530                 2535             


Asp Thr  Pro Ser Ser Glu Glu  Val Ser Tyr Glu Val  Thr Pro Lys 
    2540                 2545                 2550             


Thr Thr  Asp Val Ser Thr Pro  Lys Pro Ala Val Ile  His Glu Cys 
    2555                 2560                 2565             


Ala Glu  Glu Asp Asp Ser Glu  Asn Gly Glu Lys Lys  Arg Phe Thr 
    2570                 2575                 2580             


Pro Glu  Glu Glu Met Phe Lys  Met Val Thr Lys Ile  Lys Met Phe 
    2585                 2590                 2595             


Asp Glu  Leu Glu Gln Glu Ala  Lys Gln Lys Arg Asp  Tyr Lys Lys 
    2600                 2605                 2610             


Glu Pro  Lys Gln Glu Glu Ser  Ser Ser Ser Ser Asp  Pro Asp Ala 
    2615                 2620                 2625             


Asp Cys  Ser Val Asp Val Asp  Glu Pro Lys His Thr  Gly Ser Gly 
    2630                 2635                 2640             


Glu Asp  Glu Ser Gly Val Pro  Val Leu Val Thr Ser  Glu Ser Arg 
    2645                 2650                 2655             


Lys Val  Ser Ser Ser Ser Glu  Ser Glu Pro Glu Leu  Ala Gln Leu 
    2660                 2665                 2670             


Lys Lys  Gly Ala Asp Ser Gly  Leu Leu Pro Glu Pro  Val Ile Arg 
    2675                 2680                 2685             


Val Gln  Pro Pro Ser Pro Leu  Pro Ser Ser Met Asp  Ser Asn Ser 
    2690                 2695                 2700             


Ser Pro  Glu Glu Val Gln Phe  Gln Pro Val Val Ser  Lys Gln Tyr 
    2705                 2710                 2715             


Thr Phe  Lys Met Asn Glu Asp  Thr Gln Glu Glu Pro  Gly Lys Ser 
    2720                 2725                 2730             


Glu Glu  Glu Lys Asp Ser Glu  Ser His Leu Ala Glu  Asp Arg His 
    2735                 2740                 2745             


Ala Val  Ser Thr Glu Ala Glu  Asp Arg Ser Tyr Asp  Lys Leu Asn 
    2750                 2755                 2760             


Arg Asp  Thr Asp Gln Pro Lys  Ile Cys Asp Gly His  Gly Cys Glu 
    2765                 2770                 2775             


Ala Met  Ser Pro Ser Ser Ser  Ala Ala Pro Val Ser  Ser Gly Leu 
    2780                 2785                 2790             


Gln Ser  Pro Thr Gly Asp Asp  Val Asp Glu Gln Pro  Val Ile Tyr 
    2795                 2800                 2805             


Lys Glu  Ser Leu Ala Leu Gln  Gly Thr His Glu Lys  Asp Thr Glu 
    2810                 2815                 2820             


Gly Glu  Glu Leu Asp Val Ser  Arg Ala Glu Ser Pro  Gln Ala Asp 
    2825                 2830                 2835             


Cys Pro  Ser Glu Ser Phe Ser  Ser Ser Ser Ser Leu  Pro His Cys 
    2840                 2845                 2850             


Leu Val  Ser Glu Gly Lys Glu  Leu Asp Glu Asp Ile  Ser Ala Thr 
    2855                 2860                 2865             


Ser Ser  Ile Gln Lys Thr Glu  Val Thr Lys Thr Asp  Glu Thr Phe 
    2870                 2875                 2880             


Glu Asn  Leu Pro Lys Asp Cys  Pro Ser Gln Asp Ser  Ser Ile Thr 
    2885                 2890                 2895             


Thr Gln  Thr Asp Arg Phe Ser  Met Asp Val Pro Val  Ser Asp Leu 
    2900                 2905                 2910             


Ala Glu  Asn Asp Glu Ile Tyr  Asp Pro Gln Ile Thr  Ser Pro Tyr 
    2915                 2920                 2925             


Glu Asn  Val Pro Ser Gln Ser  Phe Phe Ser Ser Glu  Glu Ser Lys 
    2930                 2935                 2940             


Thr Gln  Thr Asp Ala Asn His  Thr Thr Ser Phe His  Ser Ser Glu 
    2945                 2950                 2955             


Val Tyr  Ser Val Thr Ile Thr  Ser Pro Val Glu Asp  Val Val Val 
    2960                 2965                 2970             


Ala Ser  Ser Ser Ser Gly Thr  Val Leu Ser Lys Glu  Ser Asn Phe 
    2975                 2980                 2985             


Glu Gly  Gln Asp Ile Lys Met  Glu Ser Gln Gln Glu  Ser Thr Leu 
    2990                 2995                 3000             


Trp Glu  Met Gln Ser Asp Ser  Val Ser Ser Ser Phe  Glu Pro Thr 
    3005                 3010                 3015             


Met Ser  Ala Thr Thr Thr Val  Val Gly Glu Gln Ile  Ser Lys Val 
    3020                 3025                 3030             


Ile Ile  Thr Lys Thr Asp Val  Asp Ser Asp Ser Trp  Ser Glu Ile 
    3035                 3040                 3045             


Arg Glu  Asp Asp Glu Ala Phe  Glu Ala Arg Val Lys  Glu Glu Glu 
    3050                 3055                 3060             


Gln Lys  Ile Phe Gly Leu Met  Val Asp Arg Gln Ser  Gln Gly Thr 
    3065                 3070                 3075             


Thr Pro  Asp Thr Thr Pro Ala  Arg Thr Pro Thr Glu  Glu Gly Thr 
    3080                 3085                 3090             


Pro Thr  Ser Glu Gln Asn Pro  Phe Leu Phe Gln Glu  Gly Lys Leu 
    3095                 3100                 3105             


Phe Glu  Met Thr Arg Ser Gly  Ala Ile Asp Met Thr  Lys Arg Ser 
    3110                 3115                 3120             


Tyr Ala  Asp Glu Ser Phe His  Phe Phe Gln Ile Gly  Gln Glu Ser 
    3125                 3130                 3135             


Arg Glu  Glu Thr Leu Ser Glu  Asp Val Lys Glu Gly  Ala Thr Gly 
    3140                 3145                 3150             


Ala Asp  Pro Leu Pro Leu Glu  Thr Ser Ala Glu Ser  Leu Ala Leu 
    3155                 3160                 3165             


Ser Glu  Ser Lys Glu Thr Val  Asp Asp Glu Ala Asp  Leu Leu Pro 
    3170                 3175                 3180             


Asp Asp  Val Ser Glu Glu Val  Glu Glu Ile Pro Ala  Ser Asp Ala 
    3185                 3190                 3195             


Gln Leu  Asn Ser Gln Met Gly  Ile Ser Ala Ser Thr  Glu Thr Pro 
    3200                 3205                 3210             


Thr Lys  Glu Ala Val Ser Val  Gly Thr Lys Asp Leu  Pro Thr Val 
    3215                 3220                 3225             


Gln Thr  Gly Asp Ile Pro Pro  Leu Ser Gly Val Lys  Gln Ile Ser 
    3230                 3235                 3240             


Cys Pro  Asp Ser Ser Glu Pro  Ala Val Gln Val Gln  Leu Asp Phe 
    3245                 3250                 3255             


Ser Thr  Leu Thr Arg Ser Val  Tyr Ser Asp Arg Gly  Asp Asp Ser 
    3260                 3265                 3270             


Pro Asp  Ser Ser Pro Glu Glu  Gln Lys Ser Val Ile  Glu Ile Pro 
    3275                 3280                 3285             


Thr Ala  Pro Met Glu Asn Val  Pro Phe Thr Glu Ser  Lys Ser Lys 
    3290                 3295                 3300             


Ile Pro  Val Arg Thr Met Pro  Thr Ser Thr Pro Ala  Pro Pro Ser 
    3305                 3310                 3315             


Ala Glu  Tyr Glu Ser Ser Val  Ser Glu Asp Phe Leu  Ser Ser Val 
    3320                 3325                 3330             


Asp Glu  Glu Asn Lys Ala Asp  Glu Ala Lys Pro Lys  Ser Lys Leu 
    3335                 3340                 3345             


Pro Val  Lys Val Pro Leu Gln  Arg Val Glu Gln Gln  Leu Ser Asp 
    3350                 3355                 3360             


Leu Asp  Thr Ser Val Gln Lys  Thr Val Ala Pro Gln  Gly Gln Asp 
    3365                 3370                 3375             


Met Ala  Ser Ile Ala Pro Asp  Asn Arg Ser Lys Ser  Glu Ser Asp 
    3380                 3385                 3390             


Ala Ser  Ser Leu Asp Ser Lys  Thr Lys Cys Pro Val  Lys Thr Arg 
    3395                 3400                 3405             


Ser Tyr  Thr Glu Thr Glu Thr  Glu Ser Arg Glu Arg  Ala Glu Glu 
    3410                 3415                 3420             


Leu Glu  Leu Glu Ser Glu Glu  Gly Ala Thr Arg Pro  Lys Ile Leu 
    3425                 3430                 3435             


Thr Ser  Arg Leu Pro Val Lys  Ser Arg Ser Thr Thr  Ser Ser Cys 
    3440                 3445                 3450             


Arg Gly  Gly Thr Ser Pro Thr  Lys Glu Ser Lys Glu  His Phe Phe 
    3455                 3460                 3465             


Asp Leu  Tyr Arg Asn Ser Ile  Glu Phe Phe Glu Glu  Ile Ser Asp 
    3470                 3475                 3480             


Glu Ala  Ser Lys Leu Val Asp  Arg Leu Thr Gln Ser  Glu Arg Glu 
    3485                 3490                 3495             


Gln Glu  Ile Val Ser Asp Asp  Glu Ser Ser Ser Ala  Leu Glu Val 
    3500                 3505                 3510             


Ser Val  Ile Glu Asn Leu Pro  Pro Val Glu Thr Glu  His Ser Val 
    3515                 3520                 3525             


Pro Glu  Asp Ile Phe Asp Thr  Arg Pro Ile Trp Asp  Glu Ser Ile 
    3530                 3535                 3540             


Glu Thr  Leu Ile Glu Arg Ile  Pro Asp Glu Asn Gly  His Asp His 
    3545                 3550                 3555             


Ala Glu  Asp Pro Gln Asp Glu  Gln Glu Arg Ile Glu  Glu Arg Leu 
    3560                 3565                 3570             


Ala Tyr  Ile Ala Asp His Leu  Gly Phe Ser Trp Thr  Glu Leu Ala 
    3575                 3580                 3585             


Arg Glu  Leu Asp Phe Thr Glu  Glu Gln Ile His Gln  Ile Arg Ile 
    3590                 3595                 3600             


Glu Asn  Pro Asn Ser Leu Gln  Asp Gln Ser His Ala  Leu Leu Lys 
    3605                 3610                 3615             


Tyr Trp  Leu Glu Arg Asp Gly  Lys His Ala Thr Asp  Thr Asn Leu 
    3620                 3625                 3630             


Val Glu  Cys Leu Thr Lys Ile  Asn Arg Met Asp Ile  Val His Leu 
    3635                 3640                 3645             


Met Glu  Thr Asn Thr Glu Pro  Leu Gln Glu Arg Ile  Ser His Ser 
    3650                 3655                 3660             


Tyr Ala  Glu Ile Glu Gln Thr  Ile Thr Leu Asp His  Ser Glu Gly 
    3665                 3670                 3675             


Phe Ser  Val Leu Gln Glu Glu  Leu Cys Thr Ala Gln  His Lys Gln 
    3680                 3685                 3690             


Lys Glu  Glu Gln Ala Val Ser  Lys Glu Ser Glu Thr  Cys Asp His 
    3695                 3700                 3705             


Pro Pro  Ile Val Ser Glu Glu  Asp Ile Ser Val Gly  Tyr Ser Thr 
    3710                 3715                 3720             


Phe Gln  Asp Gly Val Pro Lys  Thr Glu Gly Asp Ser  Ser Ala Thr 
    3725                 3730                 3735             


Ala Leu  Phe Pro Gln Thr His  Lys Glu Gln Val Gln  Gln Asp Phe 
    3740                 3745                 3750             


Ser Gly  Lys Met Gln Asp Leu  Pro Glu Glu Ser Ser  Leu Glu Tyr 
    3755                 3760                 3765             


Gln Gln  Glu Tyr Phe Val Thr  Thr Pro Gly Thr Glu  Thr Ser Glu 
    3770                 3775                 3780             


Thr Gln  Lys Ala Met Ile Val  Pro Ser Ser Pro Ser  Lys Thr Pro 
    3785                 3790                 3795             


Glu Glu  Val Ser Thr Pro Ala  Glu Glu Glu Lys Leu  Tyr Leu Gln 
    3800                 3805                 3810             


Thr Pro  Thr Ser Ser Glu Arg  Gly Gly Ser Pro Ile  Ile Gln Glu 
    3815                 3820                 3825             


Pro Glu  Glu Pro Ser Glu His  Arg Glu Glu Ser Ser  Pro Arg Lys 
    3830                 3835                 3840             


Thr Ser  Leu Val Ile Val Glu  Ser Ala Asp Asn Gln  Pro Glu Thr 
    3845                 3850                 3855             


Cys Glu  Arg Leu Asp Glu Asp  Ala Ala Phe Glu Lys  Gly Asp Asp 
    3860                 3865                 3870             


Met Pro  Glu Ile Pro Pro Glu  Thr Val Thr Glu Glu  Glu Tyr Ile 
    3875                 3880                 3885             


Asp Glu  His Gly His Thr Val  Val Lys Lys Val Thr  Arg Lys Ile 
    3890                 3895                 3900             


Ile Arg  Arg Tyr Val Ser Ser  Glu Gly Thr Glu Lys  Glu Glu Ile 
    3905                 3910                 3915             


Met Val  Gln Gly Met Pro Gln  Glu Pro Val Asn Ile  Glu Glu Gly 
    3920                 3925                 3930             


Asp Gly  Tyr Ser Lys Val Ile  Lys Arg Val Val Leu  Lys Ser Asp 
    3935                 3940                 3945             


Thr Glu  Gln Ser Glu Asp Asn  Asn Glu 
    3950                 3955         

<210>  182
<211>  7988
<212>  DNA
<213>  Homo sapiens

<400>  182
ctcctcctcc tgctttcctc cagtaagtgc atacccgcta gtggtctgta caggcggcac     60

ggtttgatgg cagagatatt ttctttccaa actgttcaaa atgatgaacg aagatgcagc    120

tcagaaaagc gacagtggag agaagttcaa cggcagtagt cagaggagaa aaagacccaa    180

gaagtctgac agcaatgcaa gcttcctccg tgctgccaga gcaggcaacc tggacaaagt    240

tgtggaatat ctgaaggggg gcatagacat caatacctgc aatcagaatg gactcaacgc    300

tctccatctg gctgccaagg aaggccacgt ggggctggtg caggagctgc tgggaagagg    360

gtcctctgtg gattctgcca ctaagaaggg aaataccgct cttcacattg catctttggc    420

tggacaagca gaagttgtca aagttcttgt taaggaagga gccaatatta atgcacagtc    480

tcagaatggc tttactcctt tatacatggc tgcccaagag aatcacattg atgttgtaaa    540

atatttgctg gaaaatggag ctaatcagag cactgctaca gaggatggct ttactcctct    600

agctgtggca ctccagcaag gacacaacca ggcggtggcc atcctcttgg agaatgacac    660

caaagggaaa gtgaggctgc cagctctgca tattgccgct aggaaagacg acaccaaatc    720

tgccgcactt ctgcttcaga atgaccacaa tgctgacgta caatccaaga tgatggtgaa    780

taggacaact gagagtggtt ttaccccttt gcacatagct gcacattacg gaaatgtcaa    840

cgtggcaact cttcttctaa accggggagc tgctgtggac ttcacagcca ggaatggaat    900

cactcctctg catgtggctt ccaaaagagg aaatacaaac atggtgaagc tcttactgga    960

tcgaggcggt cagatcgatg ccaaaactag ggatgggttg acaccacttc actgtgctgc   1020

acgaagtggg catgaccaag tggtggaact tctgttggaa cggggtgccc ccttgctggc   1080

aaggactaag aatgggctgt ctccactaca catggctgcc cagggagacc acgtggaatg   1140

tgtgaagcac ctgttacagc acaaggcacc tgttgatgat gtcaccctag actacctgac   1200

agccctccac gttgctgcgc actgtggcca ctaccgtgta accaaactcc ttttagacaa   1260

gagagccaat ccgaacgcca gagccctgaa tggttttact ccactgcaca ttgcctgcaa   1320

gaaaaaccgc atcaaagtca tggaactgct ggtgaaatat ggggcttcaa tccaagctat   1380

aacagagtct ggcctcacac caatacatgt ggctgccttc atgggccact tgaacattgt   1440

cctccttctg ctgcagaacg gagcctctcc agatgtcact aacattcgtg gtgagacggc   1500

actacacatg gcagcccgag ccgggcaggt ggaagtggtc cgatgcctcc tgagaaatgg   1560

tgcccttgtt gatgccagag ccagggagga acagacacct ttacatattg cctcccgcct   1620

gggtaagaca gaaattgtcc agctgcttct acaacatatg gctcatccag atgcggccac   1680

tacaaatggg tacacaccac tgcacatctc tgcccgggag ggccaggtgg atgtggcatc   1740

agtcctattg gaagcaggag cagcccactc cttagctacc aagaagggtt ttactcccct   1800

gcatgtagca gccaagtatg gaagcctgga tgtggcaaaa cttctcttgc aacgccgtgc   1860

tgccgcagat tctgcaggga agaacggcct taccccgctc catgttgctg ctcattatga   1920

caaccagaag gtggcgctgc tgttactgga gaagggtgct tcccctcatg ccactgccaa   1980

gaatggctat actccgttac atattgctgc caagaagaat caaatgcaga tagcttccac   2040

actcctgaac tatggagcag agacaaacat tgtgacaaag caaggagtaa ctccactcca   2100

tctggcctcg caggaggggc acacagatat ggttaccttg cttctggata agggagccaa   2160

tatccacatg tcaactaaga gtggactcac atccttacac cttgcagccc aggaagataa   2220

agtgaatgtt gctgatattc tcaccaagca tggagctgat caggatgctc atacaaagct   2280

tggttacaca cctttaattg tggcctgtca ctatggaaat gtgaaaatgg tcaactttct   2340

tctgaagcag ggagcaaatg ttaacgcaaa aaccaagaac ggctacacgc ctttgcacca   2400

ggccgctcag cagggtcaca cgcacatcat caacgtcctg ctccagcatg gggccaagcc   2460

caacgccacc actgcgaatg gcaacactgc cttggcgatt gctaagcgtc tgggctacat   2520

ctccgtggtc gacaccctga aggttgtgac tgaggaggtc accaccacca ccacaactat   2580

tacagaaaaa cacaaactaa atgtacctga gacgatgact gaggttcttg atgtttctga   2640

tgaagagggt gatgacacaa tgactggtga tgggggagaa taccttaggc ctgaggacct   2700

aaaagaactg ggtgatgact cactacccag cagtcagttc ctggatggta tgaattacct   2760

gcgatacagc ttggagggag gacgatctga cagccttcga tccttcagtt ccgacaggtc   2820

tcacactctg agccatgcct cctacctgag ggacagtgcc gtgatggatg actcagttgt   2880

gattcccagt caccaggtgt caactctagc caaggaggca gaaaggaatt cttatcgcct   2940

aagctggggc actgagaact tagacaacgt ggctctttct tctagtccta ttcattcagg   3000

tttcctggtt agttttatgg tggatgcccg aggtggtgct atgcgaggat gcagacacaa   3060

tgggctccga atcattattc cacctcggaa atgtactgct ccaacgcgag tcacctgccg   3120

actggtcaag cgccacagac tggcaacaat gcctccaatg gtggaaggag aaggcctggc   3180

cagtcgcctg atcgaagttg gaccttctgg tgctcagttc cttggtaaac ttcacctgcc   3240

aacggctcct cccccactta atgagggaga aagtttggtc agccgcattc ttcagctggg   3300

gcctcctgga accaaattcc ttgggcctgt gatcgtggag atccctcact ttgcggccct   3360

tcgaggaaag gaaagggaac tggtggtcct gcgcagtgag aatggggaca gctggaaaga   3420

gcatttctgt gactacactg aagatgaatt gaatgaaatt cttaacggca tggatgaagt   3480

actggatagc ccagaagacc tagaaaagaa acgaatctgc cgcatcatca cccgagactt   3540

cccacagtac tttgcagtgg tgtctcgtat caaacaggac agcaatctga ttggcccaga   3600

aggaggtgta ctgagcagca cagtggtgcc ccaggtgcag gccgtcttcc cagagggggc   3660

actcaccaag cggatccgcg taggcctgca ggctcaacct atgcacagtg agctggttaa   3720

gaagatccta ggcaacaaag ctaccttcag ccctatagtc actttggaac ctagaagaag   3780

aaaattccac aaaccaatta ccatgaccat tcctgtcccc aaagcttcaa gtgatgtcat   3840

gttgaatggt tttgggggag atgcaccaac cttaagatta ctatgcagca taacaggtgg   3900

aaccacccct gcccagtggg aagatattac aggaactacg ccattaacat ttgtcaatga   3960

atgtgtttcc tttacaacaa acgtgtctgc caggttctgg ctgatagatt gtcgacagat   4020

ccaggaatcc gttacttttg catcacaagt atacagagaa attatctgcg taccttatat   4080

ggccaaattt gtagtgtttg ccaaatcaca tgaccccatt gaagccaggt tgaggtgttt   4140

ctgcatgact gatgataaag tggataagac ccttgaacaa caagaaaatt ttgctgaggt   4200

ggccagaagc agggatgtgg aggtgttaga aggaaaaccc atctacgttg attgtttcgg   4260

caacttggta ccattaacta aaagtggcca gcatcatata ttcagttttt ttgccttcaa   4320

agaaaataga cttcctctat ttgtcaaggt acgcgatacg actcaggaac cttgcggacg   4380

actatcattt atgaaggagc caaaatccac gagaggcctg gtgcatcaag ctatttgcaa   4440

cttaaacatc actttgccga tttatacaaa ggaatcagag tcagatcaag aacaggagga   4500

agagatcgat atgacatcag aaaaaaatcc acaggatgag caggaacgga tcgaggaaag   4560

gctggcttat attgctgatc accttggctt cagctggaca gaattagcaa gagaactgga   4620

tttcactgag gagcaaattc atcaaattcg aattgaaaat cccaactctc ttcaagacca   4680

gagtcatgca ctgttgaagt actggctaga gagggatggg aaacatgcta cagataccaa   4740

cctcgttgaa tgtctcacca agatcaaccg aatggatatt gttcatctca tggagaccaa   4800

cacagaacct ctccaggagc gcatcagtca tagttatgca gaaattgaac agaccattac   4860

actggatcat agtgaagggt tctcggtact tcaagaggag ttatgcactg cacagcacaa   4920

gcagaaagag gagcaagctg tttctaaaga aagtgagacc tgcgatcacc ctcctatcgt   4980

ctcagaggaa gacatttctg ttggttattc cacttttcag gatggcgtcc ccaaaactga   5040

gggggacagc tcagcaacag cactctttcc ccaaactcac aaggagcaag ttcaacagga   5100

tttctcaggg aaaatgcaag acctgcctga agagtcatct ctggaatatc agcaggaata   5160

ttttgtgaca actccaggaa cagaaacatc agagactcag aaggctatga tagtacccag   5220

ctctcccagc aagacacctg aggaagttag cacccctgca gaggaggaga agctgtacct   5280

ccagacccca acatccagcg agcggggagg ctctcccatc atacaagaac ccgaagagcc   5340

ctcagagcac agagaggaga gctctccgcg gaaaaccagc ctcgtaatag tggagtctgc   5400

cgataaccag cctgagacct gtgaaagact cgatgaagat gcagcttttg aaaagggaga   5460

cgatatgcct gaaatacccc cagaaacagt cacagaagaa gaatacattg atgagcatgg   5520

acacaccgtg gtaaagaagg ttactaggaa aatcattagg cggtatgtat cctctgaagg   5580

cacagagaaa gaagagatta tggtgcaggg aatgccacag gaacctgtca acatcgagga   5640

aggggatggc tattccaaag ttataaagcg tgttgtattg aagagtgaca ccgagcagtc   5700

agaggacaac aatgagtaaa gccatcacac agaagagggc tgtggtgaag gaccagcatg   5760

gaaaacgcat tgacttggag cacctggagg atgtaccaga agcactagac caggacgacc   5820

tccagcgcga tctccagcag ctccttcggc atttctgcaa ggaggacttg aagcaagagg   5880

ccaagtgagg ggctgcccag ttctcacacc agaaaccaca cattcactca atatgcagct   5940

tcctgtttca gtaggggagt gacctaactg gcctaattaa tgggataccc cgacatttcc   6000

actgttagca aatatacggc attttgcttt agttttcccc catcctcttt aactataaag   6060

ctaatttgtg accaaagatg gcatccttca tactggatgc tgtatccaat actttgttgt   6120

gtctgtgcta acctgggaac tggccacctc cattgttctt tgcttctgca caagatccat   6180

gaaaatccat tgatcagaag aacttcacct gcagacctct tcaagtgaca ctatgtagga   6240

atccttccaa ggaatatcta tgtacaatgt atatagctga aatgctcaga tgaacaacat   6300

attaaaatta aaaccactgc ctattgtaac tacactgggc atcagaataa aaggcctcta   6360

gaaattgctg aacaatggtt aattaagata ttgctaacac aatcgagtga taatacagtt   6420

ttactgcaaa agaagcactt caaacctatt atgtccttag aacttccaga gtagccactg   6480

ctcccagtta aaggtgggtc agtagccttg cagaactgtc ctgagaagtt attgctggtg   6540

ctggccagcc atggcttagg actccaacag ccactctgag ggaggggaga agggagcaga   6600

ggccacgcag aatgaaccga tggggtattc agttgctggc agctacattg tgtggcattc   6660

tagcatcttc aggtctttag atcttggaca agttggcagg gtattttaaa agctataact   6720

actgtagttt tccagttttc attgctgctt tagcaaacca cgctgtctta cagtggtact   6780

ttcttctggc cactgcactg tagataattc attggaaaca agatttaccc actacataaa   6840

aggttaaact ccttcagtat gttggagtgg tttctttttt tttttctttc tttctttttt   6900

ttcttcaggt ttatatcttc tctaatacct gcatgtggcg tttaaaaatc aagaccacgg   6960

tcaaacccct cttctaatca cattaattgt ttccattctt tttaccctga gtgagcactt   7020

ttcactttcc agctaggtct gtttttcagc ttgcagacaa gattgagaaa tccttgaaaa   7080

tttggttttg gttaaaattt ttggtttatt tatttgaaat ccacactccc ttggaaactc   7140

ttaagtgcat ttgtgcactt ctgtttgttt gtctcaaaga agggactgta acaatctgag   7200

taatttccat gtcctcttcc ttattcctct agtggttgaa gctgtgtagc attttaacat   7260

atatatattc acaaatatat tcatataaac agtatacatt ttgaatcagt catttgttaa   7320

agaaaagtat attcaatgaa gatgaaattt aaataaaaaa ggacagagtc tatcctccag   7380

ggattgaaca ttttccaatt atctggtctt ttcctgttgt gcaaaaatga ctcattgctc   7440

cgaatgtcaa aaacaaatgc gacaaacaat ggcacttcat catttaaagt aatgttgcca   7500

agagaaaaaa tttcctggga gggaggtttc ccacaagcca aatctcctaa gcctcaaatg   7560

ctagcacttt ttggcagttg gataggaaat gagacattct ttggcagcca aaataagaga   7620

ggccgatggt gaaacttttt gagacaccct atggccttct tgtcaaaacc ttcactggag   7680

ctcaagaaaa gcatttctgt tgtgttattt gcagtgcaga tgatgtctgt gtaacaacat   7740

aatggttatt cacctttttt tgattttgat ttttgctgtg ttatcaaaaa cttgaatact   7800

gtgagaagaa gtgaattttc agttgacgaa tcagcatctt gttcccatgg tgataacact   7860

aattgaatat atctatgagg gcatgtatta gttaatggaa aaaaaaatac aacactaaca   7920

atacatagct gcaatgtgta caatggctga tttaattaaa taaaatgtac aagtgttaaa   7980

tgtggcaa                                                            7988


<210>  183
<211>  1872
<212>  PRT
<213>  Homo sapiens

<400>  183


Met Met Asn Glu Asp Ala Ala Gln Lys Ser Asp Ser Gly Glu Lys Phe 
1               5                   10                  15      


Asn Gly Ser Ser Gln Arg Arg Lys Arg Pro Lys Lys Ser Asp Ser Asn 
            20                  25                  30          


Ala Ser Phe Leu Arg Ala Ala Arg Ala Gly Asn Leu Asp Lys Val Val 
        35                  40                  45              


Glu Tyr Leu Lys Gly Gly Ile Asp Ile Asn Thr Cys Asn Gln Asn Gly 
    50                  55                  60                  


Leu Asn Ala Leu His Leu Ala Ala Lys Glu Gly His Val Gly Leu Val 
65                  70                  75                  80  


Gln Glu Leu Leu Gly Arg Gly Ser Ser Val Asp Ser Ala Thr Lys Lys 
                85                  90                  95      


Gly Asn Thr Ala Leu His Ile Ala Ser Leu Ala Gly Gln Ala Glu Val 
            100                 105                 110         


Val Lys Val Leu Val Lys Glu Gly Ala Asn Ile Asn Ala Gln Ser Gln 
        115                 120                 125             


Asn Gly Phe Thr Pro Leu Tyr Met Ala Ala Gln Glu Asn His Ile Asp 
    130                 135                 140                 


Val Val Lys Tyr Leu Leu Glu Asn Gly Ala Asn Gln Ser Thr Ala Thr 
145                 150                 155                 160 


Glu Asp Gly Phe Thr Pro Leu Ala Val Ala Leu Gln Gln Gly His Asn 
                165                 170                 175     


Gln Ala Val Ala Ile Leu Leu Glu Asn Asp Thr Lys Gly Lys Val Arg 
            180                 185                 190         


Leu Pro Ala Leu His Ile Ala Ala Arg Lys Asp Asp Thr Lys Ser Ala 
        195                 200                 205             


Ala Leu Leu Leu Gln Asn Asp His Asn Ala Asp Val Gln Ser Lys Met 
    210                 215                 220                 


Met Val Asn Arg Thr Thr Glu Ser Gly Phe Thr Pro Leu His Ile Ala 
225                 230                 235                 240 


Ala His Tyr Gly Asn Val Asn Val Ala Thr Leu Leu Leu Asn Arg Gly 
                245                 250                 255     


Ala Ala Val Asp Phe Thr Ala Arg Asn Gly Ile Thr Pro Leu His Val 
            260                 265                 270         


Ala Ser Lys Arg Gly Asn Thr Asn Met Val Lys Leu Leu Leu Asp Arg 
        275                 280                 285             


Gly Gly Gln Ile Asp Ala Lys Thr Arg Asp Gly Leu Thr Pro Leu His 
    290                 295                 300                 


Cys Ala Ala Arg Ser Gly His Asp Gln Val Val Glu Leu Leu Leu Glu 
305                 310                 315                 320 


Arg Gly Ala Pro Leu Leu Ala Arg Thr Lys Asn Gly Leu Ser Pro Leu 
                325                 330                 335     


His Met Ala Ala Gln Gly Asp His Val Glu Cys Val Lys His Leu Leu 
            340                 345                 350         


Gln His Lys Ala Pro Val Asp Asp Val Thr Leu Asp Tyr Leu Thr Ala 
        355                 360                 365             


Leu His Val Ala Ala His Cys Gly His Tyr Arg Val Thr Lys Leu Leu 
    370                 375                 380                 


Leu Asp Lys Arg Ala Asn Pro Asn Ala Arg Ala Leu Asn Gly Phe Thr 
385                 390                 395                 400 


Pro Leu His Ile Ala Cys Lys Lys Asn Arg Ile Lys Val Met Glu Leu 
                405                 410                 415     


Leu Val Lys Tyr Gly Ala Ser Ile Gln Ala Ile Thr Glu Ser Gly Leu 
            420                 425                 430         


Thr Pro Ile His Val Ala Ala Phe Met Gly His Leu Asn Ile Val Leu 
        435                 440                 445             


Leu Leu Leu Gln Asn Gly Ala Ser Pro Asp Val Thr Asn Ile Arg Gly 
    450                 455                 460                 


Glu Thr Ala Leu His Met Ala Ala Arg Ala Gly Gln Val Glu Val Val 
465                 470                 475                 480 


Arg Cys Leu Leu Arg Asn Gly Ala Leu Val Asp Ala Arg Ala Arg Glu 
                485                 490                 495     


Glu Gln Thr Pro Leu His Ile Ala Ser Arg Leu Gly Lys Thr Glu Ile 
            500                 505                 510         


Val Gln Leu Leu Leu Gln His Met Ala His Pro Asp Ala Ala Thr Thr 
        515                 520                 525             


Asn Gly Tyr Thr Pro Leu His Ile Ser Ala Arg Glu Gly Gln Val Asp 
    530                 535                 540                 


Val Ala Ser Val Leu Leu Glu Ala Gly Ala Ala His Ser Leu Ala Thr 
545                 550                 555                 560 


Lys Lys Gly Phe Thr Pro Leu His Val Ala Ala Lys Tyr Gly Ser Leu 
                565                 570                 575     


Asp Val Ala Lys Leu Leu Leu Gln Arg Arg Ala Ala Ala Asp Ser Ala 
            580                 585                 590         


Gly Lys Asn Gly Leu Thr Pro Leu His Val Ala Ala His Tyr Asp Asn 
        595                 600                 605             


Gln Lys Val Ala Leu Leu Leu Leu Glu Lys Gly Ala Ser Pro His Ala 
    610                 615                 620                 


Thr Ala Lys Asn Gly Tyr Thr Pro Leu His Ile Ala Ala Lys Lys Asn 
625                 630                 635                 640 


Gln Met Gln Ile Ala Ser Thr Leu Leu Asn Tyr Gly Ala Glu Thr Asn 
                645                 650                 655     


Ile Val Thr Lys Gln Gly Val Thr Pro Leu His Leu Ala Ser Gln Glu 
            660                 665                 670         


Gly His Thr Asp Met Val Thr Leu Leu Leu Asp Lys Gly Ala Asn Ile 
        675                 680                 685             


His Met Ser Thr Lys Ser Gly Leu Thr Ser Leu His Leu Ala Ala Gln 
    690                 695                 700                 


Glu Asp Lys Val Asn Val Ala Asp Ile Leu Thr Lys His Gly Ala Asp 
705                 710                 715                 720 


Gln Asp Ala His Thr Lys Leu Gly Tyr Thr Pro Leu Ile Val Ala Cys 
                725                 730                 735     


His Tyr Gly Asn Val Lys Met Val Asn Phe Leu Leu Lys Gln Gly Ala 
            740                 745                 750         


Asn Val Asn Ala Lys Thr Lys Asn Gly Tyr Thr Pro Leu His Gln Ala 
        755                 760                 765             


Ala Gln Gln Gly His Thr His Ile Ile Asn Val Leu Leu Gln His Gly 
    770                 775                 780                 


Ala Lys Pro Asn Ala Thr Thr Ala Asn Gly Asn Thr Ala Leu Ala Ile 
785                 790                 795                 800 


Ala Lys Arg Leu Gly Tyr Ile Ser Val Val Asp Thr Leu Lys Val Val 
                805                 810                 815     


Thr Glu Glu Val Thr Thr Thr Thr Thr Thr Ile Thr Glu Lys His Lys 
            820                 825                 830         


Leu Asn Val Pro Glu Thr Met Thr Glu Val Leu Asp Val Ser Asp Glu 
        835                 840                 845             


Glu Gly Asp Asp Thr Met Thr Gly Asp Gly Gly Glu Tyr Leu Arg Pro 
    850                 855                 860                 


Glu Asp Leu Lys Glu Leu Gly Asp Asp Ser Leu Pro Ser Ser Gln Phe 
865                 870                 875                 880 


Leu Asp Gly Met Asn Tyr Leu Arg Tyr Ser Leu Glu Gly Gly Arg Ser 
                885                 890                 895     


Asp Ser Leu Arg Ser Phe Ser Ser Asp Arg Ser His Thr Leu Ser His 
            900                 905                 910         


Ala Ser Tyr Leu Arg Asp Ser Ala Val Met Asp Asp Ser Val Val Ile 
        915                 920                 925             


Pro Ser His Gln Val Ser Thr Leu Ala Lys Glu Ala Glu Arg Asn Ser 
    930                 935                 940                 


Tyr Arg Leu Ser Trp Gly Thr Glu Asn Leu Asp Asn Val Ala Leu Ser 
945                 950                 955                 960 


Ser Ser Pro Ile His Ser Gly Phe Leu Val Ser Phe Met Val Asp Ala 
                965                 970                 975     


Arg Gly Gly Ala Met Arg Gly Cys Arg His Asn Gly Leu Arg Ile Ile 
            980                 985                 990         


Ile Pro Pro Arg Lys Cys Thr Ala  Pro Thr Arg Val Thr  Cys Arg Leu 
        995                 1000                 1005             


Val Lys  Arg His Arg Leu Ala  Thr Met Pro Pro Met  Val Glu Gly 
    1010                 1015                 1020             


Glu Gly  Leu Ala Ser Arg Leu  Ile Glu Val Gly Pro  Ser Gly Ala 
    1025                 1030                 1035             


Gln Phe  Leu Gly Lys Leu His  Leu Pro Thr Ala Pro  Pro Pro Leu 
    1040                 1045                 1050             


Asn Glu  Gly Glu Ser Leu Val  Ser Arg Ile Leu Gln  Leu Gly Pro 
    1055                 1060                 1065             


Pro Gly  Thr Lys Phe Leu Gly  Pro Val Ile Val Glu  Ile Pro His 
    1070                 1075                 1080             


Phe Ala  Ala Leu Arg Gly Lys  Glu Arg Glu Leu Val  Val Leu Arg 
    1085                 1090                 1095             


Ser Glu  Asn Gly Asp Ser Trp  Lys Glu His Phe Cys  Asp Tyr Thr 
    1100                 1105                 1110             


Glu Asp  Glu Leu Asn Glu Ile  Leu Asn Gly Met Asp  Glu Val Leu 
    1115                 1120                 1125             


Asp Ser  Pro Glu Asp Leu Glu  Lys Lys Arg Ile Cys  Arg Ile Ile 
    1130                 1135                 1140             


Thr Arg  Asp Phe Pro Gln Tyr  Phe Ala Val Val Ser  Arg Ile Lys 
    1145                 1150                 1155             


Gln Asp  Ser Asn Leu Ile Gly  Pro Glu Gly Gly Val  Leu Ser Ser 
    1160                 1165                 1170             


Thr Val  Val Pro Gln Val Gln  Ala Val Phe Pro Glu  Gly Ala Leu 
    1175                 1180                 1185             


Thr Lys  Arg Ile Arg Val Gly  Leu Gln Ala Gln Pro  Met His Ser 
    1190                 1195                 1200             


Glu Leu  Val Lys Lys Ile Leu  Gly Asn Lys Ala Thr  Phe Ser Pro 
    1205                 1210                 1215             


Ile Val  Thr Leu Glu Pro Arg  Arg Arg Lys Phe His  Lys Pro Ile 
    1220                 1225                 1230             


Thr Met  Thr Ile Pro Val Pro  Lys Ala Ser Ser Asp  Val Met Leu 
    1235                 1240                 1245             


Asn Gly  Phe Gly Gly Asp Ala  Pro Thr Leu Arg Leu  Leu Cys Ser 
    1250                 1255                 1260             


Ile Thr  Gly Gly Thr Thr Pro  Ala Gln Trp Glu Asp  Ile Thr Gly 
    1265                 1270                 1275             


Thr Thr  Pro Leu Thr Phe Val  Asn Glu Cys Val Ser  Phe Thr Thr 
    1280                 1285                 1290             


Asn Val  Ser Ala Arg Phe Trp  Leu Ile Asp Cys Arg  Gln Ile Gln 
    1295                 1300                 1305             


Glu Ser  Val Thr Phe Ala Ser  Gln Val Tyr Arg Glu  Ile Ile Cys 
    1310                 1315                 1320             


Val Pro  Tyr Met Ala Lys Phe  Val Val Phe Ala Lys  Ser His Asp 
    1325                 1330                 1335             


Pro Ile  Glu Ala Arg Leu Arg  Cys Phe Cys Met Thr  Asp Asp Lys 
    1340                 1345                 1350             


Val Asp  Lys Thr Leu Glu Gln  Gln Glu Asn Phe Ala  Glu Val Ala 
    1355                 1360                 1365             


Arg Ser  Arg Asp Val Glu Val  Leu Glu Gly Lys Pro  Ile Tyr Val 
    1370                 1375                 1380             


Asp Cys  Phe Gly Asn Leu Val  Pro Leu Thr Lys Ser  Gly Gln His 
    1385                 1390                 1395             


His Ile  Phe Ser Phe Phe Ala  Phe Lys Glu Asn Arg  Leu Pro Leu 
    1400                 1405                 1410             


Phe Val  Lys Val Arg Asp Thr  Thr Gln Glu Pro Cys  Gly Arg Leu 
    1415                 1420                 1425             


Ser Phe  Met Lys Glu Pro Lys  Ser Thr Arg Gly Leu  Val His Gln 
    1430                 1435                 1440             


Ala Ile  Cys Asn Leu Asn Ile  Thr Leu Pro Ile Tyr  Thr Lys Glu 
    1445                 1450                 1455             


Ser Glu  Ser Asp Gln Glu Gln  Glu Glu Glu Ile Asp  Met Thr Ser 
    1460                 1465                 1470             


Glu Lys  Asn Pro Gln Asp Glu  Gln Glu Arg Ile Glu  Glu Arg Leu 
    1475                 1480                 1485             


Ala Tyr  Ile Ala Asp His Leu  Gly Phe Ser Trp Thr  Glu Leu Ala 
    1490                 1495                 1500             


Arg Glu  Leu Asp Phe Thr Glu  Glu Gln Ile His Gln  Ile Arg Ile 
    1505                 1510                 1515             


Glu Asn  Pro Asn Ser Leu Gln  Asp Gln Ser His Ala  Leu Leu Lys 
    1520                 1525                 1530             


Tyr Trp  Leu Glu Arg Asp Gly  Lys His Ala Thr Asp  Thr Asn Leu 
    1535                 1540                 1545             


Val Glu  Cys Leu Thr Lys Ile  Asn Arg Met Asp Ile  Val His Leu 
    1550                 1555                 1560             


Met Glu  Thr Asn Thr Glu Pro  Leu Gln Glu Arg Ile  Ser His Ser 
    1565                 1570                 1575             


Tyr Ala  Glu Ile Glu Gln Thr  Ile Thr Leu Asp His  Ser Glu Gly 
    1580                 1585                 1590             


Phe Ser  Val Leu Gln Glu Glu  Leu Cys Thr Ala Gln  His Lys Gln 
    1595                 1600                 1605             


Lys Glu  Glu Gln Ala Val Ser  Lys Glu Ser Glu Thr  Cys Asp His 
    1610                 1615                 1620             


Pro Pro  Ile Val Ser Glu Glu  Asp Ile Ser Val Gly  Tyr Ser Thr 
    1625                 1630                 1635             


Phe Gln  Asp Gly Val Pro Lys  Thr Glu Gly Asp Ser  Ser Ala Thr 
    1640                 1645                 1650             


Ala Leu  Phe Pro Gln Thr His  Lys Glu Gln Val Gln  Gln Asp Phe 
    1655                 1660                 1665             


Ser Gly  Lys Met Gln Asp Leu  Pro Glu Glu Ser Ser  Leu Glu Tyr 
    1670                 1675                 1680             


Gln Gln  Glu Tyr Phe Val Thr  Thr Pro Gly Thr Glu  Thr Ser Glu 
    1685                 1690                 1695             


Thr Gln  Lys Ala Met Ile Val  Pro Ser Ser Pro Ser  Lys Thr Pro 
    1700                 1705                 1710             


Glu Glu  Val Ser Thr Pro Ala  Glu Glu Glu Lys Leu  Tyr Leu Gln 
    1715                 1720                 1725             


Thr Pro  Thr Ser Ser Glu Arg  Gly Gly Ser Pro Ile  Ile Gln Glu 
    1730                 1735                 1740             


Pro Glu  Glu Pro Ser Glu His  Arg Glu Glu Ser Ser  Pro Arg Lys 
    1745                 1750                 1755             


Thr Ser  Leu Val Ile Val Glu  Ser Ala Asp Asn Gln  Pro Glu Thr 
    1760                 1765                 1770             


Cys Glu  Arg Leu Asp Glu Asp  Ala Ala Phe Glu Lys  Gly Asp Asp 
    1775                 1780                 1785             


Met Pro  Glu Ile Pro Pro Glu  Thr Val Thr Glu Glu  Glu Tyr Ile 
    1790                 1795                 1800             


Asp Glu  His Gly His Thr Val  Val Lys Lys Val Thr  Arg Lys Ile 
    1805                 1810                 1815             


Ile Arg  Arg Tyr Val Ser Ser  Glu Gly Thr Glu Lys  Glu Glu Ile 
    1820                 1825                 1830             


Met Val  Gln Gly Met Pro Gln  Glu Pro Val Asn Ile  Glu Glu Gly 
    1835                 1840                 1845             


Asp Gly  Tyr Ser Lys Val Ile  Lys Arg Val Val Leu  Lys Ser Asp 
    1850                 1855                 1860             


Thr Glu  Gln Ser Glu Asp Asn  Asn Glu 
    1865                 1870         

<210>  184
<211>  484
<212>  DNA
<213>  Homo sapiens

<400>  184
ggctcctctc tccggtccgt gcctccaaga tgacaaagaa aagaaggaac aatggtcgtg     60

ccaaaaaggg ccgcggccac gtgcagccta ttcgctgcac taactgtgcc cgatgcgtgc    120

ccaaggacaa ggccattaag aaattcgtca ttcgaaacat agtggaggcc gcagcagtca    180

gggacatttc tgaagcgagc gtcttcgatg cctatgtgct tcccaagctg tatgtgaagc    240

tacattactg tgtgagttgt gcaattcaca gcaaagtagt caggaatcga tctcgtgaag    300

cccgcaagga ccgaacaccc ccaccccgat ttagacctgc gggtgctgcc ccacgtcccc    360

caccaaagcc catgtaagga gctgagttct taaagactga agacaggcta ttctctggag    420

aaaaataaaa tggaaattgt acttaaaaaa aaaataaaaa aaaaaaataa ataaaacagc    480

attt                                                                 484


<210>  185
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  185


Met Thr Lys Lys Arg Arg Asn Asn Gly Arg Ala Lys Lys Gly Arg Gly 
1               5                   10                  15      


His Val Gln Pro Ile Arg Cys Thr Asn Cys Ala Arg Cys Val Pro Lys 
            20                  25                  30          


Asp Lys Ala Ile Lys Lys Phe Val Ile Arg Asn Ile Val Glu Ala Ala 
        35                  40                  45              


Ala Val Arg Asp Ile Ser Glu Ala Ser Val Phe Asp Ala Tyr Val Leu 
    50                  55                  60                  


Pro Lys Leu Tyr Val Lys Leu His Tyr Cys Val Ser Cys Ala Ile His 
65                  70                  75                  80  


Ser Lys Val Val Arg Asn Arg Ser Arg Glu Ala Arg Lys Asp Arg Thr 
                85                  90                  95      


Pro Pro Pro Arg Phe Arg Pro Ala Gly Ala Ala Pro Arg Pro Pro Pro 
            100                 105                 110         


Lys Pro Met 
        115 

<210>  186
<211>  532
<212>  DNA
<213>  Homo sapiens

<400>  186
atgagcaatt gtgctgagaa acaaaggaga gtggatgaag aacacagcag cctgcctcca     60

cagctttgga atcgatgtgc aaataatttc cttgggagga actctttata tacaagagga    120

ttcactccaa attgtacacc acactcaggc atgggactaa gataatgaaa gagaggcacc    180

tgactcaagc aatggatgtc ggagcagaag actagaaggc aaagcaagta catgctacct    240

gtctgggcaa gacctttcag tgcctttcca tatttcaatg ggtagtcatc tgcacacctt    300

ccagtctttt cttctgtatt gcaaaggcta gaagccttgg tactatattt atcaaactta    360

cttttttttt ttttaacaaa tcttcaatgt gattctcatt ttgctaagat acatttgtat    420

gaaattttga gatagaaaag tatgaataag aaagcattgc cttctttctc agtggcagca    480

cacaaacata tggacttcac agacacgaca ttttgcagca acttctagat ct            532


<210>  187
<211>  54
<212>  PRT
<213>  Homo sapiens

<400>  187


Met Ser Asn Cys Ala Glu Lys Gln Arg Arg Val Asp Glu Glu His Ser 
1               5                   10                  15      


Ser Leu Pro Pro Gln Leu Trp Asn Arg Cys Ala Asn Asn Phe Leu Gly 
            20                  25                  30          


Arg Asn Ser Leu Tyr Thr Arg Gly Phe Thr Pro Asn Cys Thr Pro His 
        35                  40                  45              


Ser Gly Met Gly Leu Arg 
    50                  

<210>  188
<211>  1854
<212>  DNA
<213>  Homo sapiens

<400>  188
ttggggagtt atgcgccagt gccccagtga ccgcgggaca cggagagggg aagtctgcgt     60

tgtacataag gacctaggga ctccgagctt ggcctgagaa cccttggacg ccgagtgctt    120

gccttacggg ctgcactcct caactctgct ccaaagcagc cgctgagctc aactcctgcg    180

tccagggcgt tcgctgcgcg ccaggacgcg cttagtaccc agttcctggg ctctctcttc    240

agtagctgct ttgaaagctc ccacgcacgt cccgcaggct agcctggcaa caaaactggg    300

gtaaaccgtg ttatcttagg tcttgtcccc cagaacatga cctagaggta cctgcgcatg    360

cagatggccg atgcagccac gatagccacc atgaataagg cagcaggcgg ggacaagcta    420

gcagaactct tcagtctggt cccggacctt ctggaggcgg ccaacacgag tggtaacgcg    480

tcgctgcagc ttccggactt gtggtgggag ctggggctgg agttgccgga cggcgcgccg    540

ccaggacatc ccccgggcag cggcggggca gagagcgcgg acacagaggc ccgggtgcgg    600

attctcatca gcgtggtgta ctgggtggtg tgcgccctgg ggttggcggg caacctgctg    660

gttctctacc tgatgaagag catgcagggc tggcgcaagt cctctatcaa cctcttcgtc    720

accaacctgg cgctgacgga ctttcagttt gtgctcaccc tgcccttctg ggcggtggag    780

aacgctcttg acttcaaatg gcccttcggc aaggccatgt gtaagatcgt gtccatggtg    840

acgtccatga acatgtacgc cagcgtgttc ttcctcactg ccatgagtgt gacgcgctac    900

cattcggtgg cctcggctct gaagagccac cggacccgag gacacggccg gggcgactgc    960

tgcggccgga gcctggggga cagctgctgc ttctcggcca aggcgctgtg tgtgtggatc   1020

tgggctttgg ccgcgctggc ctcgctgccc agtgccattt tctccaccac ggtcaaggtg   1080

atgggcgagg agctgtgcct ggtgcgtttc ccggacaagt tgctgggccg cgacaggcag   1140

ttctggctgg gcctctacca ctcgcagaag gtgctgttgg gcttcgtgct gccgctgggc   1200

atcattatct tgtgctacct gctgctggtg cgcttcatcg ccgaccgccg cgcggcgggg   1260

accaaaggag gggccgcggt agccggagga cgcccgaccg gagccagcgc ccggagactg   1320

tcgaaggtca ccaaatcagt gaccatcgtt gtcctgtcct tcttcctgtg ttggctgccc   1380

aaccaggcgc tcaccacctg gagcatcctc atcaagttca acgcggtgcc cttcagccag   1440

gagtatttcc tgtgccaggt atacgcgttc cctgtgagcg tgtgcctagc gcactccaac   1500

agctgcctca accccgtcct ctactgcctc gtgcgccgcg agttccgcaa ggcgctcaag   1560

agcctgctgt ggcgcatcgc gtctccttcg atcaccagca tgcgcccctt caccgccact   1620

accaagccgg agcacgagga tcaggggctg caggccccgg cgccgcccca cgcggccgcg   1680

gagccggacc tgctctacta cccacctggc gtcgtggtct acagcggggg gcgctacgac   1740

ctgctgccca gcagctctgc ctactgacgc aggcctcagg cccagggcgc gccgtcgggg   1800

caaggtggcc ttccccgggc ggtaaagagg tgaaaggatg aaggagggct gggg         1854


<210>  189
<211>  469
<212>  PRT
<213>  Homo sapiens

<400>  189


Met Gln Met Ala Asp Ala Ala Thr Ile Ala Thr Met Asn Lys Ala Ala 
1               5                   10                  15      


Gly Gly Asp Lys Leu Ala Glu Leu Phe Ser Leu Val Pro Asp Leu Leu 
            20                  25                  30          


Glu Ala Ala Asn Thr Ser Gly Asn Ala Ser Leu Gln Leu Pro Asp Leu 
        35                  40                  45              


Trp Trp Glu Leu Gly Leu Glu Leu Pro Asp Gly Ala Pro Pro Gly His 
    50                  55                  60                  


Pro Pro Gly Ser Gly Gly Ala Glu Ser Ala Asp Thr Glu Ala Arg Val 
65                  70                  75                  80  


Arg Ile Leu Ile Ser Val Val Tyr Trp Val Val Cys Ala Leu Gly Leu 
                85                  90                  95      


Ala Gly Asn Leu Leu Val Leu Tyr Leu Met Lys Ser Met Gln Gly Trp 
            100                 105                 110         


Arg Lys Ser Ser Ile Asn Leu Phe Val Thr Asn Leu Ala Leu Thr Asp 
        115                 120                 125             


Phe Gln Phe Val Leu Thr Leu Pro Phe Trp Ala Val Glu Asn Ala Leu 
    130                 135                 140                 


Asp Phe Lys Trp Pro Phe Gly Lys Ala Met Cys Lys Ile Val Ser Met 
145                 150                 155                 160 


Val Thr Ser Met Asn Met Tyr Ala Ser Val Phe Phe Leu Thr Ala Met 
                165                 170                 175     


Ser Val Thr Arg Tyr His Ser Val Ala Ser Ala Leu Lys Ser His Arg 
            180                 185                 190         


Thr Arg Gly His Gly Arg Gly Asp Cys Cys Gly Arg Ser Leu Gly Asp 
        195                 200                 205             


Ser Cys Cys Phe Ser Ala Lys Ala Leu Cys Val Trp Ile Trp Ala Leu 
    210                 215                 220                 


Ala Ala Leu Ala Ser Leu Pro Ser Ala Ile Phe Ser Thr Thr Val Lys 
225                 230                 235                 240 


Val Met Gly Glu Glu Leu Cys Leu Val Arg Phe Pro Asp Lys Leu Leu 
                245                 250                 255     


Gly Arg Asp Arg Gln Phe Trp Leu Gly Leu Tyr His Ser Gln Lys Val 
            260                 265                 270         


Leu Leu Gly Phe Val Leu Pro Leu Gly Ile Ile Ile Leu Cys Tyr Leu 
        275                 280                 285             


Leu Leu Val Arg Phe Ile Ala Asp Arg Arg Ala Ala Gly Thr Lys Gly 
    290                 295                 300                 


Gly Ala Ala Val Ala Gly Gly Arg Pro Thr Gly Ala Ser Ala Arg Arg 
305                 310                 315                 320 


Leu Ser Lys Val Thr Lys Ser Val Thr Ile Val Val Leu Ser Phe Phe 
                325                 330                 335     


Leu Cys Trp Leu Pro Asn Gln Ala Leu Thr Thr Trp Ser Ile Leu Ile 
            340                 345                 350         


Lys Phe Asn Ala Val Pro Phe Ser Gln Glu Tyr Phe Leu Cys Gln Val 
        355                 360                 365             


Tyr Ala Phe Pro Val Ser Val Cys Leu Ala His Ser Asn Ser Cys Leu 
    370                 375                 380                 


Asn Pro Val Leu Tyr Cys Leu Val Arg Arg Glu Phe Arg Lys Ala Leu 
385                 390                 395                 400 


Lys Ser Leu Leu Trp Arg Ile Ala Ser Pro Ser Ile Thr Ser Met Arg 
                405                 410                 415     


Pro Phe Thr Ala Thr Thr Lys Pro Glu His Glu Asp Gln Gly Leu Gln 
            420                 425                 430         


Ala Pro Ala Pro Pro His Ala Ala Ala Glu Pro Asp Leu Leu Tyr Tyr 
        435                 440                 445             


Pro Pro Gly Val Val Val Tyr Ser Gly Gly Arg Tyr Asp Leu Leu Pro 
    450                 455                 460                 


Ser Ser Ser Ala Tyr 
465                 

<210>  190
<211>  1161
<212>  DNA
<213>  Homo sapiens

<400>  190
atgacagcag ccaaacttct accatcctcc tatctagtag aaaaacggag ggtaggtctt     60

cgcagccatc aagttgtgac cacaatcctc tgtcatagtg gggtagcatc cgacgtgctg    120

caggcctcag gacccacgtt ttgcagttca cagttcacag tacggaggaa tgggctaagt    180

cacactacag caggctcccc tccacgtcta acagaggggg cggggggttt tcttggaaga    240

ctcggccagt gtcaggcagc aagggatgac catctggatc tcggcgcccg cgatgcggcg    300

gaagctccgg cggcgccgaa agtcgctgag gcgcggcaag gctggggagg cagcggggtg    360

gccccgggag gcaaccgagg cggccgcggc cgcgtggtgc tgctcggtgc ccagcgaggt    420

gcggcgcatg aactggcggt gcatgcggag cagcgcgccg cacacaagca cgttgcagag    480

gacggtggcg agaatgagga aggagctgaa gcccgcgtac atgtaggagt aggcggcgtg    540

cgccgtcacg ttggtggtcc agtcgatgaa gcaccaggtg tctgggtact gcagccgcga    600

gctaccgaga cccatgttgg gcagcgcgca aaagagcacg ttggacgcat agactgcaaa    660

gagcgtgagg cccgccaatc gcttgtccac gtagtggctg tagaaatagg catggttgat    720

ggccaggtag cgctcgacac tcatggcgca gatgatgctg aggccggaca ggctgaagaa    780

gagcagaatg aaggtgctgt actcgcacag cggctggccc ccgggccatt ggcccttcat    840

gtacgtggcg atggtcaccg ggctcaccaa caaagtgccc aacaggtcgg tgacagccag    900

cccacatacc agcgtgtaga aggtcgtctc cttctgctcc ttgcgcgact tgcacagcac    960

cacgatggcc accaggttgc ccaccacccc gaagatgaac atcaccgccg ggatggtcac   1020

tgggctgttc agccggtcgg ggctcaagga ggcggacgaa ttgaccccgg gagtggacat   1080

gatagtggct ggcggtgcgc agccttggac tccgctctcg cctttccacc ctctgccatg   1140

cagagactca aaacagtgtg a                                             1161


<210>  191
<211>  386
<212>  PRT
<213>  Homo sapiens

<400>  191


Met Thr Ala Ala Lys Leu Leu Pro Ser Ser Tyr Leu Val Glu Lys Arg 
1               5                   10                  15      


Arg Val Gly Leu Arg Ser His Gln Val Val Thr Thr Ile Leu Cys His 
            20                  25                  30          


Ser Gly Val Ala Ser Asp Val Leu Gln Ala Ser Gly Pro Thr Phe Cys 
        35                  40                  45              


Ser Ser Gln Phe Thr Val Arg Arg Asn Gly Leu Ser His Thr Thr Ala 
    50                  55                  60                  


Gly Ser Pro Pro Arg Leu Thr Glu Gly Ala Gly Gly Phe Leu Gly Arg 
65                  70                  75                  80  


Leu Gly Gln Cys Gln Ala Ala Arg Asp Asp His Leu Asp Leu Gly Ala 
                85                  90                  95      


Arg Asp Ala Ala Glu Ala Pro Ala Ala Pro Lys Val Ala Glu Ala Arg 
            100                 105                 110         


Gln Gly Trp Gly Gly Ser Gly Val Ala Pro Gly Gly Asn Arg Gly Gly 
        115                 120                 125             


Arg Gly Arg Val Val Leu Leu Gly Ala Gln Arg Gly Ala Ala His Glu 
    130                 135                 140                 


Leu Ala Val His Ala Glu Gln Arg Ala Ala His Lys His Val Ala Glu 
145                 150                 155                 160 


Asp Gly Gly Glu Asn Glu Glu Gly Ala Glu Ala Arg Val His Val Gly 
                165                 170                 175     


Val Gly Gly Val Arg Arg His Val Gly Gly Pro Val Asp Glu Ala Pro 
            180                 185                 190         


Gly Val Trp Val Leu Gln Pro Arg Ala Thr Glu Thr His Val Gly Gln 
        195                 200                 205             


Arg Ala Lys Glu His Val Gly Arg Ile Asp Cys Lys Glu Arg Glu Ala 
    210                 215                 220                 


Arg Gln Ser Leu Val His Val Val Ala Val Glu Ile Gly Met Val Asp 
225                 230                 235                 240 


Gly Gln Val Ala Leu Asp Thr His Gly Ala Asp Asp Ala Glu Ala Gly 
                245                 250                 255     


Gln Ala Glu Glu Glu Gln Asn Glu Gly Ala Val Leu Ala Gln Arg Leu 
            260                 265                 270         


Ala Pro Gly Pro Leu Ala Leu His Val Arg Gly Asp Gly His Arg Ala 
        275                 280                 285             


His Gln Gln Ser Ala Gln Gln Val Gly Asp Ser Gln Pro Thr Tyr Gln 
    290                 295                 300                 


Arg Val Glu Gly Arg Leu Leu Leu Leu Leu Ala Arg Leu Ala Gln His 
305                 310                 315                 320 


His Asp Gly His Gln Val Ala His His Pro Glu Asp Glu His His Arg 
                325                 330                 335     


Arg Asp Gly His Trp Ala Val Gln Pro Val Gly Ala Gln Gly Gly Gly 
            340                 345                 350         


Arg Ile Asp Pro Gly Ser Gly His Asp Ser Gly Trp Arg Cys Ala Ala 
        355                 360                 365             


Leu Asp Ser Ala Leu Ala Phe Pro Pro Ser Ala Met Gln Arg Leu Lys 
    370                 375                 380                 


Thr Val 
385     

<210>  192
<211>  3432
<212>  DNA
<213>  Homo sapiens

<400>  192
gcgagagcgg agctccaagc ccggcagccc gagaggaaga tgaacagccc caggccagag     60

cctctggcag agtggacccc gagccgcccc caggtagcca ggagcggcct cagcggcagc    120

cgcaaactcc agtagccgcc cgtgctgccc gtggctgggg cggagggcag ccagagctgg    180

ggaccaaggc tccgcgccac ctgcgcgcac agcctcacac ctgaacgctg tcctcccgca    240

gacgagaccg gcgggcactg caaagctggg actcgtcttt gaaggaaaaa aaatagcgag    300

taagaaatcc agcaccattc ttcactgacc catcccgctg cacctcttgt ttcccaagtt    360

tttgaaagct ggcaactctg acctcggtgt ccaaaaatcg acagccactg agaccggctt    420

tgagaagccg aagatttggc agtttccaga ctgagcagga caaggtgaaa gcaggttgga    480

ggcgggtcca ggacatctga gggctgaccc tgggggctcg tgaggctgcc accgctgctg    540

ccgctacaga cccagccttg cactccaagg ctgcgcaccg ccagccacta tcatgtccac    600

tcccggggtc aattcgtccg cctccttgag ccccgaccgg ctgaacagcc cagtgaccat    660

cccggcggtg atgttcatct tcggggtggt gggcaacctg gtggccatcg tggtgctgtg    720

caagtcgcgc aaggagcaga aggagacgac cttctacacg ctggtatgtg ggctggctgt    780

caccgacctg ttgggcactt tgttggtgag cccggtgacc atcgccacgt acatgaaggg    840

ccaatggccc gggggccagc cgctgtgcga gtacagcacc ttcattctgc tcttcttcag    900

cctgtccggc ctcagcatca tctgcgccat gagtgtcgag cgctacctgg ccatcaacca    960

tgcctatttc tacagccact acgtggacaa gcgattggcg ggcctcacgc tctttgcagt   1020

ctatgcgtcc aacgtgctct tttgcgcgct gcccaacatg ggtctcggta gctcgcggct   1080

gcagtaccca gacacctggt gcttcatcga ctggaccacc aacgtgacgg cgcacgccgc   1140

ctactcctac atgtacgcgg gcttcagctc cttcctcatt ctcgccaccg tcctctgcaa   1200

cgtgcttgtg tgcggcgcgc tgctccgcat gcaccgccag ttcatgcgcc gcacctcgct   1260

gggcaccgag cagcaccacg cggccgcggc cgcctcggtt gcctcccggg gccaccccgc   1320

tgcctcccca gccttgccgc gcctcagcga ctttcggcgc cgccggagct tccgccgcat   1380

cgcgggcgcc gagatccaga tggtcatctt actcattgcc acctccctgg tggtgctcat   1440

ctgctccatc ccgctcgtgg tgcgagtatt cgtcaaccag ttatatcagc caagtttgga   1500

gcgagaagtc agtaaaaatc cagatttgca ggccatccga attgcttctg tgaaccccat   1560

cctagacccc tggatatata tcctcctgag aaagacagtg ctcagtaaag caatagagaa   1620

gatcaaatgc ctcttctgcc gcattggcgg gtcccgcagg gagcgctccg gacagcactg   1680

ctcagacagt caaaggacat cttctgccat gtcaggccac tctcgctcct tcatctcccg   1740

ggagctgaag gagatcagca gtacatctca gaccctcctg ccagacctct cactgccaga   1800

cctcagtgaa aatggccttg gaggcaggaa tttgcttcca ggtgtgcctg gcatgggcct   1860

ggcccaggaa gacaccacct cactgaggac tttgcgaata tcagagacct cagactcttc   1920

acagggtcag gactcagaga gtgtcttact ggtggatgag gctggtggga gcggcagggc   1980

tgggcctgcc cctaagggga gctccctgca agtcacattt cccagtgaaa cactgaactt   2040

atcagaaaaa tgtatataat aggcaaggaa agaaatacag tactgtttct ggacccttat   2100

aaaatcctgt gcaatagaca catacatgtc acatttagct gtgctcagaa gggctatcat   2160

catcctacaa ctcacattag agaacatcct ggcttttgag cacttttcaa acaatcaagt   2220

tgactcacgt gggtcctgag gcctgcagca cgtcggatgc taccccacta tgacagagga   2280

ttgtggtcac aacttgatgg ctgcgaagac ctaccctccg tttttctact agataggagg   2340

atggtagaag tttggctgct gtcataacat ccagagcttt gtcgtatttg gcacacagca   2400

gaggcccaga tattagaaag gctctattcc aataaactat gaggactgcc ttatggatga   2460

tttaagtgtc tcactaaagc atgaaatgtg aatttttatt gttgtacata cgatttaagg   2520

tatttaaagt attttcttct ctgtgagaag gtttattgtt aatacaaggt ataataaaat   2580

tatcgcaacc cctctccttc cagtataacc agctgaagtt gcagatgtta gatatttttc   2640

ataaacaagt tcgagtcaaa gttgaaaatt catagtaaga ttgatatcta taaaatagat   2700

ataaattttt aagagaaaga atttagtatt atcaaaggga taaagaaaaa aatactattt   2760

aagatgtgaa aattacagtc caaaatactg ttctttccag gctatgtata aaatacatag   2820

tgaaaattgt ttagtgatat tacatttatt tatccagaaa actgtgattt caggagaacc   2880

taacatgctg gtgaatattt tcaacttttt ccctcactaa ttggtacttt taaaaacata   2940

acataaattt tttgaagtct ttaataaata acccataatt gaagtgtata atataaaaaa   3000

ttttaaaaat ctaagcagct tattgtttct ctgaaagtgt gtgtagtttt actttcctaa   3060

ggaattacca agaatatcct ttaaaattta aaaggatggc aagttgcatc agaaagcttt   3120

attttgagat gtaaaaagat tcccaaacgt ggttacatta gccattcatg tatgtcagaa   3180

gtgcagaatt ggggcactta atggtcacct tgtaacagtt ttgtgtaact cccagtgatg   3240

ctgtacacat atttgaaggg tctttctcaa agaaatatta agcatgtttt gttgctcagt   3300

gtttttgtga attgcttggt tgtaattaaa ttctgagcct gatattgata tggttttaag   3360

aagcagttgt accaagtgaa attattttgg agattataat aaatatatac attcaaaaaa   3420

aaaaaaaaaa aa                                                       3432


<210>  193
<211>  488
<212>  PRT
<213>  Homo sapiens

<400>  193


Met Ser Thr Pro Gly Val Asn Ser Ser Ala Ser Leu Ser Pro Asp Arg 
1               5                   10                  15      


Leu Asn Ser Pro Val Thr Ile Pro Ala Val Met Phe Ile Phe Gly Val 
            20                  25                  30          


Val Gly Asn Leu Val Ala Ile Val Val Leu Cys Lys Ser Arg Lys Glu 
        35                  40                  45              


Gln Lys Glu Thr Thr Phe Tyr Thr Leu Val Cys Gly Leu Ala Val Thr 
    50                  55                  60                  


Asp Leu Leu Gly Thr Leu Leu Val Ser Pro Val Thr Ile Ala Thr Tyr 
65                  70                  75                  80  


Met Lys Gly Gln Trp Pro Gly Gly Gln Pro Leu Cys Glu Tyr Ser Thr 
                85                  90                  95      


Phe Ile Leu Leu Phe Phe Ser Leu Ser Gly Leu Ser Ile Ile Cys Ala 
            100                 105                 110         


Met Ser Val Glu Arg Tyr Leu Ala Ile Asn His Ala Tyr Phe Tyr Ser 
        115                 120                 125             


His Tyr Val Asp Lys Arg Leu Ala Gly Leu Thr Leu Phe Ala Val Tyr 
    130                 135                 140                 


Ala Ser Asn Val Leu Phe Cys Ala Leu Pro Asn Met Gly Leu Gly Ser 
145                 150                 155                 160 


Ser Arg Leu Gln Tyr Pro Asp Thr Trp Cys Phe Ile Asp Trp Thr Thr 
                165                 170                 175     


Asn Val Thr Ala His Ala Ala Tyr Ser Tyr Met Tyr Ala Gly Phe Ser 
            180                 185                 190         


Ser Phe Leu Ile Leu Ala Thr Val Leu Cys Asn Val Leu Val Cys Gly 
        195                 200                 205             


Ala Leu Leu Arg Met His Arg Gln Phe Met Arg Arg Thr Ser Leu Gly 
    210                 215                 220                 


Thr Glu Gln His His Ala Ala Ala Ala Ala Ser Val Ala Ser Arg Gly 
225                 230                 235                 240 


His Pro Ala Ala Ser Pro Ala Leu Pro Arg Leu Ser Asp Phe Arg Arg 
                245                 250                 255     


Arg Arg Ser Phe Arg Arg Ile Ala Gly Ala Glu Ile Gln Met Val Ile 
            260                 265                 270         


Leu Leu Ile Ala Thr Ser Leu Val Val Leu Ile Cys Ser Ile Pro Leu 
        275                 280                 285             


Val Val Arg Val Phe Val Asn Gln Leu Tyr Gln Pro Ser Leu Glu Arg 
    290                 295                 300                 


Glu Val Ser Lys Asn Pro Asp Leu Gln Ala Ile Arg Ile Ala Ser Val 
305                 310                 315                 320 


Asn Pro Ile Leu Asp Pro Trp Ile Tyr Ile Leu Leu Arg Lys Thr Val 
                325                 330                 335     


Leu Ser Lys Ala Ile Glu Lys Ile Lys Cys Leu Phe Cys Arg Ile Gly 
            340                 345                 350         


Gly Ser Arg Arg Glu Arg Ser Gly Gln His Cys Ser Asp Ser Gln Arg 
        355                 360                 365             


Thr Ser Ser Ala Met Ser Gly His Ser Arg Ser Phe Ile Ser Arg Glu 
    370                 375                 380                 


Leu Lys Glu Ile Ser Ser Thr Ser Gln Thr Leu Leu Pro Asp Leu Ser 
385                 390                 395                 400 


Leu Pro Asp Leu Ser Glu Asn Gly Leu Gly Gly Arg Asn Leu Leu Pro 
                405                 410                 415     


Gly Val Pro Gly Met Gly Leu Ala Gln Glu Asp Thr Thr Ser Leu Arg 
            420                 425                 430         


Thr Leu Arg Ile Ser Glu Thr Ser Asp Ser Ser Gln Gly Gln Asp Ser 
        435                 440                 445             


Glu Ser Val Leu Leu Val Asp Glu Ala Gly Gly Ser Gly Arg Ala Gly 
    450                 455                 460                 


Pro Ala Pro Lys Gly Ser Ser Leu Gln Val Thr Phe Pro Ser Glu Thr 
465                 470                 475                 480 


Leu Asn Leu Ser Glu Lys Cys Ile 
                485             

<210>  194
<211>  5519
<212>  DNA
<213>  Homo sapiens

<400>  194
gacttctggg atttgtggtc ccggagaaga gattggcgga ggggaaagac tgagtcgtct     60

ttcctttgcc cgcttctgtg gactgttcga acgcccaggg gtgggccaaa cccgtttctt    120

aggaaaccag gaatccaggg aaggcagaat ggcttccttt gggtggaaga ggaaaattgg    180

tgagaaggtc tcaaaggtca cttcccagca gtttgaagct gaagctgctg atgagaagga    240

tgtagttgac aacgatgaag ggaactggct tcatgccatt aaacgtagga aagaaattct    300

tcttgaaggc tgtgctgaga aaagtaaaca gctgaaggat gaaggagcca gtttggctga    360

aaataaaaga tatcgggagg caattcagaa gtgggatgaa gcactacagt taactccaaa    420

tgatgctacc ctatacgaga tgaaatcaca ggtgctaatg tctcttcatg aaatgttccc    480

agcagtacat gcagcagaaa tggccgtcca gcaaaatcca cattcatggg agtcttggca    540

gactttggga cgtgctcaac ttggtttagg agagataatc ctggcaattc gaagttttca    600

agtagccctt cacatctatc caatgaaccc tgaaatatgg aaagaagacc tctcttgggc    660

aagaacgctc caggagcagc agaaggtagc acagaggatt aaaaaaagtg aagcaccagc    720

tgaagtaaca cacttttcac caaagtcaat tccagactat gactttgaaa gtgatgagat    780

tgttgctgtt tgtgcagcta ttgctgagaa agagaagaca gtttcagcaa ataaaacaat    840

ggttattgtg tctgcttctg gggccataga gactgtaact gaaaaggagg atggtgctac    900

accaccagat ggctctgttt ttatcaaagc ccgatgaagc agtatgcata ggattatttg    960

aatctgtctt tttgattgcc tcttgaagtt ttgacataga gacatttact ctggagatag   1020

ataggagaac gcctggttgt aaaatatgtt tttcagatga ggcatataaa aactaaaatg   1080

gcaggattat tgtatagtgt ttggaatatg ctttgataag ttatgattta tatttctcaa   1140

ggttaaaatt ctgagtaaaa tggtctttga ttaataaact tagtttaatc tgaatatgta   1200

aatgaataca ttttaaagac aaaacttgaa aaatgtattc ttgaatagtg aataatttga   1260

tcaatgttac tgaaatgctg tctcaacttt tgttttatga taaaggaagt gtgtgatttc   1320

cctccctctg agaaatatac tgcgcttaat atttgctgtc tttttcttgc ttcattagag   1380

taagtctgtc agaaagcttg aatatttttg acattcattt tgattcaaag ttgtcatttg   1440

gttatatgtg gaatctttga aagtttggct gaaaatgcac acaaatgtgt acattctgaa   1500

cattttctga agtttctctt aattctgatt tgtgtttctg ttttgacttt gaagttgtaa   1560

caatgatagt tgtctccttc agtatttggt aaaagtgtaa agtattgata aatatgagaa   1620

tgatggtttt attttttaat tgttacagta agtaatcctt accacaaatg agtcattttt   1680

aaaatatgca tttttaaatg aatggctttt acagataggt taatgacaat tgtactgcta   1740

tattatccca gtcaaaacca atactttctt ttctttattt tacaaagctt taaaaaccct   1800

ggaaacaact tacttcttgc ttgtgtcttt ccatttgatg actgggaatt acttttctag   1860

ataacttttt ttgaaactac tcagtgaaat gaaaaataat tacaatttta aatagctaat   1920

tatatctttc taaaaataaa aaagtagggc tgttattaga gtgccaatga ataaataact   1980

taagcacaaa atacatagaa attggaatgt gatttatagt acaatctcat gagtatgaaa   2040

aggctatatt aaaaaaaatt ttattgaaag tccacagtca tattcacaaa ccaatactgt   2100

cattgctaat ctgaactatt atttttatac tatatattgt agtacaataa tatagaactg   2160

ttgggttctg ttacttctga cactcaggaa gatactattg gtgtattaat tttatctttg   2220

ttagagatga aagtagccca ctttatgtta aagatcttac tactgttgga gcttataagt   2280

aatgatctac attttttatg aagatggttt ttaaaacttt tgttttattg gaatgcatat   2340

ctcttttcag ggttggagaa attagcactt gccttgaaaa gaatattctt tccttaagtt   2400

atatcatcag aaaattagct ctggttagag aggttagttt cagagtgctc caaaaaatat   2460

gttaattatt ttattttgtt taataaagaa cattctcaaa acgtaaatag gtatctagag   2520

aagtgagtac tcaacatttg gtatattgtt ttgagtaatg gatgtttgtt ttttgtgtaa   2580

tttgtgaata aatagttttt ttctgcattt tgaagatttt cctattattt tatgttgtta   2640

gcttttgaaa aattagattg atctacttag tgtctttctt atatgaactt aatatattta   2700

aagtaccttg catggtgcct cacacatgaa gtaatgccag ctatttcagt aaatgctagc   2760

tatttctatg aagaacttga gttagtttgg agatatttaa cctcaatttc ctctgatttt   2820

aaaaaaggag aacttttttt gtaatccttt ccttatctga aagtaagaag tctctgattc   2880

cagtattata ggagagatag tgggattttt cttgacaggg tctatagctc aagtcccaaa   2940

gaggcaagac tcaggatgga atgcatgtgg ccactaggcc ctgttataag aacctagtgt   3000

ttcctctgta ctggcatggt aggccaagtt agtctctttc ttacccagat ataagacata   3060

aaatagttta gacataagac agaggagaaa aagaaacagt aagttatgga gaaggaaggc   3120

agctcatttc tgcaggcccc tcaaaatgct tattttagct catactcttc tatgcgtgaa   3180

gagaaaaatg cacccattat tttacaagga tgtgaatact gatatacaaa catagactaa   3240

gcttgttaat tttaataaca aatctttatg aatctgaaga gaattgatgt tcatgataat   3300

gatatagatg tttaatatac tttctgaaat aacactgttt actgttcaag ttatattgac   3360

tataatttac attattcttg tttgagaatt gtatggcata gacactcatt agtcagagtg   3420

tctagacatc cagaccatgc ctgataacac aagaatcata tatcattctc tagaaaacag   3480

gctgtttggt tatagagtat ttatcttaaa tatattaaca gacactacat aaacattgaa   3540

aagccatgca agttatagct cacaggagcc agatctactg caactggggc ctacatacaa   3600

aattttatgg cagtggtttc agtatgacaa tcttttgaat tgatgccgta tggtaaaact   3660

ataaagattt tttaaaagct ctgtctcagc tagaattttt aagattataa ctgaacagta   3720

tagccctttt agttgtttga aaattacata atgattcaaa agcttgtttc actgcctttc   3780

ccagcactaa gaaaattaac aatcatttct tttaatttcc ttgaatcaga gccattctaa   3840

agtgactctg gaccagcaat tctgagctat gatttcatga tacatgtatt aatatctaaa   3900

tgagttgtga gttgacataa gaaccatagt tccataataa ttatcttcaa atcaatggat   3960

atcttaaatg tgtttttttc ttccttagag attattatta aactgatgta tttgataata   4020

aagaatttta ggactgagaa agttaagttt ttcttaccaa taataagata ttgaaatata   4080

taaattataa aacagaaata aaatgaaata aaggaggtta tccctaaagt catttacctt   4140

agtcacttgc aattaaatat ggttacttcg gaagaagaag tgtggcccta aagctactgt   4200

aacatgaatc atgccctaat gtgcactata tatgaactac tttggtcaga aggcagcggc   4260

gggtaaggat ggcttcctct cacagtgctt cttaggctat ccatttacca aggaattcta   4320

atctctttct ctcacttcac caggaaagga gggagtttaa gatatagaac tgggcatgct   4380

agcctctttt ttcccttttg tggatttgtc ataactgcag agaaccgatg ttgtggtctc   4440

ttgccagcta cattgtgaac cttgcagtga aagttctttg cctctgcaaa gggagatttg   4500

tgcttgtgca gaactgccca tgccttagta agcaggtctg tctaattcta agttcaatat   4560

ctggtggcta ttgttggcat aaacttaaag tacatcctct aacctagcct ttttcagcag   4620

taaacttaaa atattgaatc tccatctgtc tgtgtctcaa gtggttcaga ggtcaggaga   4680

ggagagggac attattttat gactccctca aactttaaca aagactagtg cagattatat   4740

ttcgaagtaa gcatgagata tattaaaaac cacatgtggg aattctttcc taattttaga   4800

ggtttttttt aaataatgga aattctattg aaattgagta gtgttaatta caaggcaaca   4860

ggtaaacatt tgttcaggat atttaaaagg tctgctgagt tggaattgtg acagaccaca   4920

ttgttgactc tagattgaat tggaagggaa gaatgtgaaa tgaattagga tatcctctgt   4980

tcacctctat taactttctt aaatgagtat aacttagaaa taataaaatg caagtatttt   5040

aacgttatag ttgggagagt tttgacaaat gtaaacaccc acttcaccac cactaccatc   5100

ctgatatagt gtgtgtccat cacccaaaaa gttctctaaa gcccttttgc agttggttcc   5160

cctccacctg aacagccatc cctagtcaac tacttttctg ctttctgtgg ctatacgtta   5220

gatttgactt cagaattcta gagtttgaaa taaataggcc atataatatg cactcttttt   5280

gtgtctgact ttttttttgc ttaacatgat gcttttgaaa cccatccatg ttgagattca   5340

tccatgttat catgtgtatc aataataagt tcctttttat tgctgaatag tattctagta   5400

tatagatata ccacaatttg tttagctgtt cacctattga tggacattta ggttgtttca   5460

agttttgatc tattatgaat aaagctgcta tatatataaa tcacaaaaaa aaaaaaaaa    5519


<210>  195
<211>  262
<212>  PRT
<213>  Homo sapiens

<400>  195


Met Ala Ser Phe Gly Trp Lys Arg Lys Ile Gly Glu Lys Val Ser Lys 
1               5                   10                  15      


Val Thr Ser Gln Gln Phe Glu Ala Glu Ala Ala Asp Glu Lys Asp Val 
            20                  25                  30          


Val Asp Asn Asp Glu Gly Asn Trp Leu His Ala Ile Lys Arg Arg Lys 
        35                  40                  45              


Glu Ile Leu Leu Glu Gly Cys Ala Glu Lys Ser Lys Gln Leu Lys Asp 
    50                  55                  60                  


Glu Gly Ala Ser Leu Ala Glu Asn Lys Arg Tyr Arg Glu Ala Ile Gln 
65                  70                  75                  80  


Lys Trp Asp Glu Ala Leu Gln Leu Thr Pro Asn Asp Ala Thr Leu Tyr 
                85                  90                  95      


Glu Met Lys Ser Gln Val Leu Met Ser Leu His Glu Met Phe Pro Ala 
            100                 105                 110         


Val His Ala Ala Glu Met Ala Val Gln Gln Asn Pro His Ser Trp Glu 
        115                 120                 125             


Ser Trp Gln Thr Leu Gly Arg Ala Gln Leu Gly Leu Gly Glu Ile Ile 
    130                 135                 140                 


Leu Ala Ile Arg Ser Phe Gln Val Ala Leu His Ile Tyr Pro Met Asn 
145                 150                 155                 160 


Pro Glu Ile Trp Lys Glu Asp Leu Ser Trp Ala Arg Thr Leu Gln Glu 
                165                 170                 175     


Gln Gln Lys Val Ala Gln Arg Ile Lys Lys Ser Glu Ala Pro Ala Glu 
            180                 185                 190         


Val Thr His Phe Ser Pro Lys Ser Ile Pro Asp Tyr Asp Phe Glu Ser 
        195                 200                 205             


Asp Glu Ile Val Ala Val Cys Ala Ala Ile Ala Glu Lys Glu Lys Thr 
    210                 215                 220                 


Val Ser Ala Asn Lys Thr Met Val Ile Val Ser Ala Ser Gly Ala Ile 
225                 230                 235                 240 


Glu Thr Val Thr Glu Lys Glu Asp Gly Ala Thr Pro Pro Asp Gly Ser 
                245                 250                 255     


Val Phe Ile Lys Ala Arg 
            260         

<210>  196
<211>  5085
<212>  DNA
<213>  Homo sapiens

<400>  196
agcgccatgc gcagactcag ttcctggaga aagatggcga cagccgagaa gcagaaacac     60

gacgggcggg tgaagatcgg ccactacatt ctgggtgaca cgctgggggt cggcaccttc    120

ggcaaagtga aggttggcaa acatgaattg actgggcata aagtagctgt gaagatactc    180

aatcgacaga agattcggag ccttgatgtg gtaggaaaaa tccgcagaga aattcagaac    240

ctcaagcttt tcaggcatcc tcatataatt aaactgtacc aggtcatcag tacaccatct    300

gatattttca tggtgatgga atatgtctca ggaggagagc tatttgatta tatctgtaag    360

aatggaaggc tggatgaaaa agaaagtcgg cgtctgttcc aacagatcct ttctggtgtg    420

gattattgtc acaggcatat ggtggtccat agagatttga aacctgaaaa tgtcctgctt    480

gatgcacaca tgaatgcaaa gatagctgat tttggtcttt caaacatgat gtcagatggt    540

gaatttttaa gaacaagttg tggctcaccc aactatgctg caccagaagt aatttcagga    600

agattgtatg caggcccaga ggtagatata tggagcagtg gggttattct ctatgcttta    660

ttatgtggaa cccttccatt tgatgatgac catgtgccaa ctctttttaa gaagatatgt    720

gatgggatct tctatacccc tcaatattta aatccttctg tgattagcct tttgaaacat    780

atgctgcagg tggatcccat gaagagggcc acaatcaaag atatcaggga acatgaatgg    840

tttaaacagg accttccaaa atatctcttt cctgaggatc catcatatag ttcaaccatg    900

attgatgatg aagccttaaa agaagtatgt gaaaagtttg agtgctcaga agaggaagtt    960

ctcagctgtc tttacaacag aaatcaccag gatcctttgg cagttgccta ccatctcata   1020

atagataaca ggagaataat gaatgaagcc aaagatttct atttggcgac aagcccacct   1080

gattcttttc ttgatgatca tcacctgact cggccccatc ctgaaagagt accattcttg   1140

gttgctgaaa caccaagggc acgccatacc cttgatgaat taaatccaca gaaatccaaa   1200

caccaaggtg taaggaaagc aaaatggcat ttaggaatta gaagtcaaag tcgaccaaat   1260

gatattatgg cagaagtatg tagagcaatc aaacaattgg attatgaatg gaaggttgta   1320

aacccatatt atttgcgtgt acgaaggaag aatcctgtga caagcactta ctccaaaatg   1380

agtctacagt tataccaagt ggatagtaga acttatctac tggatttccg tagtattgat   1440

gatgaaatta cagaagccaa atcagggact gctactccac agagatcggg atcagttagc   1500

aactatcgat cttgccaaag gagtgattca gatgctgagg ctcaaggaaa atcctcagaa   1560

gtttctctta cctcatctgt gacctcactt gactcttctc ctgttgacct aactccaaga   1620

cctggaagtc acacaataga attttttgag atgtgtgcaa atctaattaa aattcttgca   1680

caataaacag aaaactttgc ttatttcttt tgcagcaata agcatgcata ataagtcaca   1740

gccaaatgct tccatttgta atcaagttat acataattat aaccgagggc tggcgttttg   1800

gaatgcaatt tgcacaggga ttggaacatg atttatagtt aaaagcctaa tatgcagaaa   1860

tgaattaaga tcattttgtt gttcattgtg cagtatgtat atagcataat atacacagtg   1920

aattataggt ctcaggctta cttgattttt ggctatttta tatttagtgt acacagggct   1980

ttgaaatatt aatttacata aaggccttca tatattatta cgtgttatat attacgtgtt   2040

ataaatttat tcaataaata tttgcctaga attcccaaga cctttatagg tgattttgtt   2100

ttctgggctc cttaacttca taaatagcta gtatcttcca gcagtagtaa cagtctggat   2160

aacttcttcc atatccctcc ctctttgttt ttttgagaca gtgtcacttt gtcacccagg   2220

ctggagtgca atggtgtggt ctcggctcac tgcaacctcc acctcccggg ttcaagtgat   2280

tctcccgcct cagcttcctg agtagctgga actacaggcg tgtgccacca cacccggcta   2340

atttttcgta tttttagtgt agacggggtt tcactatgtt gcccaggctg gtctcgaact   2400

cctgaccgcg tgatccacca cctcagcttc ccaaagtggt gggattacag gcgtgagcca   2460

ccgcacccgg cctccatatc ccccttttaa aattctgtag tgtatggtaa gtcatatcag   2520

atatcagacc taatttaaat ttcattttag ctttacaagt ccaaaaacac agaatttata   2580

tattcagata ctctagcact aattttagtc ttaaaatatt cccacgatat tctgtacaca   2640

aaatgttctt tttgttacaa gagctgagtt gcatatactg tagataaatc atattatttt   2700

tgccaatttc acaaattcct ctggcccatc atgtcagtca ttattgagta tatgcacaca   2760

ttgctactta tttgattatg tatcttttaa attgattcag tgcatagaaa actatctctt   2820

acaaacttta agtgctctga tatgacttcc cccccaaatt ttattatgaa catttttaaa   2880

aacagaaaaa ttgaaaaact gtttggtaag cacatgtata tctaccattt agattcagca   2940

gttgttaatg ttttgtcatt tgttttctct atacctatat atgtatagat acagctagtt   3000

atgcatatat atgcatatat gtgtttgttt gtgtatgtat atatgctttt ttccccctga   3060

accatttgga tgttacagac atacttatca ccgtgaaaat acttcaagta tctcctacag   3120

ataatgacat tctcctaaaa atccgtaata ccattgtaaa agtaataatt ccccaatatc   3180

atctaatcaa gccatattta aatttctgaa gttaactcca aatttcttta tagctgatta   3240

tttcaaacta ggatccaatt aaagtttaca tatgacactt ggttataact ctttagttgg   3300

atataacatt attattattt tgataaaata tggaacaaat caattctatt aataagtggt   3360

cacatttgtt ttgggcttaa attacttttt aaagatactg gattttccta agatttctga   3420

tttacactga tatttttttt tgtcattctt aattgcatca cacaatagat gtaaatgaag   3480

atgtagtcac ctcagataaa attggtatcg tgtatgataa tattgtatca tttatatttg   3540

ccttatgtta actttaagaa attgattttt ttgtattaat cattttccca ttgcaacaga   3600

gctatatttt ttctatttta agaatcatat tttaggatta tttttggcaa atacagtgag   3660

cacttatgta accagatgat aatgaactca aatgtcatga tagcttgcat aaatggtgac   3720

tctagtagat ttgactcaag cacttctaga atcatgcact gaattcaaaa gaaaaatctt   3780

gctgcttttt gtccagggct tgttctattc aacttctaat ttgaaagctg tacaaagtaa   3840

tagaagttcc atttaaatat gagttcaaaa ctgtatttac tttttatgtg gccctctctt   3900

taggggattc taattttact tagggtctct aagtgcagca taatgttcct gatgttaaca   3960

gaagactgta tttttaaagt tacaaatttg tatatggaat taagtaatgg cgctatatac   4020

gctgttgtgg ggagggggga agaaaaggag gaaccaatta aataggacct tttaaaaatt   4080

gttaattttg taaactttgc ttctcttata agttattgtg attcatttta gttactgtgt   4140

tttattttga aaatatttaa atattgcact tctataaata gtatgataaa tgcacagaca   4200

attgcagtaa attctttttt aagctaggat atttgaaatg acaacctttg gttaagtgtg   4260

tcaaggttgc aacagaattt tcacaatttt tttgttgttt gcaaattgtt actaatattg   4320

aagaggtaag ggaggcaatg caaatgattt ttaatctttt tttattatct tttcagcagt   4380

ttatattttt tgtgacttta tgcaaccata tttttacttt gtcttgacaa ctgaaagatg   4440

tataaggttt tttgccagaa atgtactgta tacatagttt taagtataac agattttact   4500

gatatgtaaa aattttgcca ttaaaataaa tgatttctca ctgagaggaa cttttctacc   4560

aggttggggc atatgggagc ttaatatatc atatctaatt taaaataatt tcactgaaat   4620

aaactccatt gcttttacct aatttttttc ttgagatgct tttgtagttt ttcagagttt   4680

tagatgattt tatacaaaat cctctgccta gcactgctct ttttgatgtt gtagtgacac   4740

catttacatt gaattaatgc ttggtagcct ggggctagat gtggaactcc atggatctgt   4800

gttctgactg gcacctttgg aatgaaagaa aagtgtgtgc tgtccaaatt ttttcccctt   4860

aattctttcc ctcatcttct cacccataat agaaatttta tttccattgt gagttctgac   4920

aagaatgaaa ttccacatac aacataactg taaattgttg gtaggtagaa gttaatattt   4980

gtggttcatg tatattttga ccagagtata tttaagtata taatttcagc ttccttgatt   5040

tagaaatatg atataataaa gaaaaactcc atttatcatc tgtta                   5085


<210>  197
<211>  559
<212>  PRT
<213>  Homo sapiens

<400>  197


Met Arg Arg Leu Ser Ser Trp Arg Lys Met Ala Thr Ala Glu Lys Gln 
1               5                   10                  15      


Lys His Asp Gly Arg Val Lys Ile Gly His Tyr Ile Leu Gly Asp Thr 
            20                  25                  30          


Leu Gly Val Gly Thr Phe Gly Lys Val Lys Val Gly Lys His Glu Leu 
        35                  40                  45              


Thr Gly His Lys Val Ala Val Lys Ile Leu Asn Arg Gln Lys Ile Arg 
    50                  55                  60                  


Ser Leu Asp Val Val Gly Lys Ile Arg Arg Glu Ile Gln Asn Leu Lys 
65                  70                  75                  80  


Leu Phe Arg His Pro His Ile Ile Lys Leu Tyr Gln Val Ile Ser Thr 
                85                  90                  95      


Pro Ser Asp Ile Phe Met Val Met Glu Tyr Val Ser Gly Gly Glu Leu 
            100                 105                 110         


Phe Asp Tyr Ile Cys Lys Asn Gly Arg Leu Asp Glu Lys Glu Ser Arg 
        115                 120                 125             


Arg Leu Phe Gln Gln Ile Leu Ser Gly Val Asp Tyr Cys His Arg His 
    130                 135                 140                 


Met Val Val His Arg Asp Leu Lys Pro Glu Asn Val Leu Leu Asp Ala 
145                 150                 155                 160 


His Met Asn Ala Lys Ile Ala Asp Phe Gly Leu Ser Asn Met Met Ser 
                165                 170                 175     


Asp Gly Glu Phe Leu Arg Thr Ser Cys Gly Ser Pro Asn Tyr Ala Ala 
            180                 185                 190         


Pro Glu Val Ile Ser Gly Arg Leu Tyr Ala Gly Pro Glu Val Asp Ile 
        195                 200                 205             


Trp Ser Ser Gly Val Ile Leu Tyr Ala Leu Leu Cys Gly Thr Leu Pro 
    210                 215                 220                 


Phe Asp Asp Asp His Val Pro Thr Leu Phe Lys Lys Ile Cys Asp Gly 
225                 230                 235                 240 


Ile Phe Tyr Thr Pro Gln Tyr Leu Asn Pro Ser Val Ile Ser Leu Leu 
                245                 250                 255     


Lys His Met Leu Gln Val Asp Pro Met Lys Arg Ala Thr Ile Lys Asp 
            260                 265                 270         


Ile Arg Glu His Glu Trp Phe Lys Gln Asp Leu Pro Lys Tyr Leu Phe 
        275                 280                 285             


Pro Glu Asp Pro Ser Tyr Ser Ser Thr Met Ile Asp Asp Glu Ala Leu 
    290                 295                 300                 


Lys Glu Val Cys Glu Lys Phe Glu Cys Ser Glu Glu Glu Val Leu Ser 
305                 310                 315                 320 


Cys Leu Tyr Asn Arg Asn His Gln Asp Pro Leu Ala Val Ala Tyr His 
                325                 330                 335     


Leu Ile Ile Asp Asn Arg Arg Ile Met Asn Glu Ala Lys Asp Phe Tyr 
            340                 345                 350         


Leu Ala Thr Ser Pro Pro Asp Ser Phe Leu Asp Asp His His Leu Thr 
        355                 360                 365             


Arg Pro His Pro Glu Arg Val Pro Phe Leu Val Ala Glu Thr Pro Arg 
    370                 375                 380                 


Ala Arg His Thr Leu Asp Glu Leu Asn Pro Gln Lys Ser Lys His Gln 
385                 390                 395                 400 


Gly Val Arg Lys Ala Lys Trp His Leu Gly Ile Arg Ser Gln Ser Arg 
                405                 410                 415     


Pro Asn Asp Ile Met Ala Glu Val Cys Arg Ala Ile Lys Gln Leu Asp 
            420                 425                 430         


Tyr Glu Trp Lys Val Val Asn Pro Tyr Tyr Leu Arg Val Arg Arg Lys 
        435                 440                 445             


Asn Pro Val Thr Ser Thr Tyr Ser Lys Met Ser Leu Gln Leu Tyr Gln 
    450                 455                 460                 


Val Asp Ser Arg Thr Tyr Leu Leu Asp Phe Arg Ser Ile Asp Asp Glu 
465                 470                 475                 480 


Ile Thr Glu Ala Lys Ser Gly Thr Ala Thr Pro Gln Arg Ser Gly Ser 
                485                 490                 495     


Val Ser Asn Tyr Arg Ser Cys Gln Arg Ser Asp Ser Asp Ala Glu Ala 
            500                 505                 510         


Gln Gly Lys Ser Ser Glu Val Ser Leu Thr Ser Ser Val Thr Ser Leu 
        515                 520                 525             


Asp Ser Ser Pro Val Asp Leu Thr Pro Arg Pro Gly Ser His Thr Ile 
    530                 535                 540                 


Glu Phe Phe Glu Met Cys Ala Asn Leu Ile Lys Ile Leu Ala Gln 
545                 550                 555                 

<210>  198
<211>  5130
<212>  DNA
<213>  Homo sapiens

<400>  198
agcgccatgc gcagactcag ttcctggaga aagatggcga cagccgagaa gcagaaacac     60

gacgggcggg tgaagatcgg ccactacatt ctgggtgaca cgctgggggt cggcaccttc    120

ggcaaagtga aggttggcaa acatgaattg actgggcata aagtagctgt gaagatactc    180

aatcgacaga agattcggag ccttgatgtg gtaggaaaaa tccgcagaga aattcagaac    240

ctcaagcttt tcaggcatcc tcatataatt aaactgtacc aggtcatcag tacaccatct    300

gatattttca tggtgatgga atatgtctca ggaggagagc tatttgatta tatctgtaag    360

aatggaagga aatctgatgt acctggagta gtaaaaacag gctccacgaa ggagctggat    420

gaaaaagaaa gtcggcgtct gttccaacag atcctttctg gtgtggatta ttgtcacagg    480

catatggtgg tccatagaga tttgaaacct gaaaatgtcc tgcttgatgc acacatgaat    540

gcaaagatag ctgattttgg tctttcaaac atgatgtcag atggtgaatt tttaagaaca    600

agttgtggct cacccaacta tgctgcacca gaagtaattt caggaagatt gtatgcaggc    660

ccagaggtag atatatggag cagtggggtt attctctatg ctttattatg tggaaccctt    720

ccatttgatg atgaccatgt gccaactctt tttaagaaga tatgtgatgg gatcttctat    780

acccctcaat atttaaatcc ttctgtgatt agccttttga aacatatgct gcaggtggat    840

cccatgaaga gggccacaat caaagatatc agggaacatg aatggtttaa acaggacctt    900

ccaaaatatc tctttcctga ggatccatca tatagttcaa ccatgattga tgatgaagcc    960

ttaaaagaag tatgtgaaaa gtttgagtgc tcagaagagg aagttctcag ctgtctttac   1020

aacagaaatc accaggatcc tttggcagtt gcctaccatc tcataataga taacaggaga   1080

ataatgaatg aagccaaaga tttctatttg gcgacaagcc cacctgattc ttttcttgat   1140

gatcatcacc tgactcggcc ccatcctgaa agagtaccat tcttggttgc tgaaacacca   1200

agggcacgcc atacccttga tgaattaaat ccacagaaat ccaaacacca aggtgtaagg   1260

aaagcaaaat ggcatttagg aattagaagt caaagtcgac caaatgatat tatggcagaa   1320

gtatgtagag caatcaaaca attggattat gaatggaagg ttgtaaaccc atattatttg   1380

cgtgtacgaa ggaagaatcc tgtgacaagc acttactcca aaatgagtct acagttatac   1440

caagtggata gtagaactta tctactggat ttccgtagta ttgatgatga aattacagaa   1500

gccaaatcag ggactgctac tccacagaga tcgggatcag ttagcaacta tcgatcttgc   1560

caaaggagtg attcagatgc tgaggctcaa ggaaaatcct cagaagtttc tcttacctca   1620

tctgtgacct cacttgactc ttctcctgtt gacctaactc caagacctgg aagtcacaca   1680

atagaatttt ttgagatgtg tgcaaatcta attaaaattc ttgcacaata aacagaaaac   1740

tttgcttatt tcttttgcag caataagcat gcataataag tcacagccaa atgcttccat   1800

ttgtaatcaa gttatacata attataaccg agggctggcg ttttggaatg caatttgcac   1860

agggattgga acatgattta tagttaaaag cctaatatgc agaaatgaat taagatcatt   1920

ttgttgttca ttgtgcagta tgtatatagc ataatataca cagtgaatta taggtctcag   1980

gcttacttga tttttggcta ttttatattt agtgtacaca gggctttgaa atattaattt   2040

acataaaggc cttcatatat tattacgtgt tatatattac gtgttataaa tttattcaat   2100

aaatatttgc ctagaattcc caagaccttt ataggtgatt ttgttttctg ggctccttaa   2160

cttcataaat agctagtatc ttccagcagt agtaacagtc tggataactt cttccatatc   2220

cctccctctt tgtttttttg agacagtgtc actttgtcac ccaggctgga gtgcaatggt   2280

gtggtctcgg ctcactgcaa cctccacctc ccgggttcaa gtgattctcc cgcctcagct   2340

tcctgagtag ctggaactac aggcgtgtgc caccacaccc ggctaatttt tcgtattttt   2400

agtgtagacg gggtttcact atgttgccca ggctggtctc gaactcctga ccgcgtgatc   2460

caccacctca gcttcccaaa gtggtgggat tacaggcgtg agccaccgca cccggcctcc   2520

atatccccct tttaaaattc tgtagtgtat ggtaagtcat atcagatatc agacctaatt   2580

taaatttcat tttagcttta caagtccaaa aacacagaat ttatatattc agatactcta   2640

gcactaattt tagtcttaaa atattcccac gatattctgt acacaaaatg ttctttttgt   2700

tacaagagct gagttgcata tactgtagat aaatcatatt atttttgcca atttcacaaa   2760

ttcctctggc ccatcatgtc agtcattatt gagtatatgc acacattgct acttatttga   2820

ttatgtatct tttaaattga ttcagtgcat agaaaactat ctcttacaaa ctttaagtgc   2880

tctgatatga cttccccccc aaattttatt atgaacattt ttaaaaacag aaaaattgaa   2940

aaactgtttg gtaagcacat gtatatctac catttagatt cagcagttgt taatgttttg   3000

tcatttgttt tctctatacc tatatatgta tagatacagc tagttatgca tatatatgca   3060

tatatgtgtt tgtttgtgta tgtatatatg cttttttccc cctgaaccat ttggatgtta   3120

cagacatact tatcaccgtg aaaatacttc aagtatctcc tacagataat gacattctcc   3180

taaaaatccg taataccatt gtaaaagtaa taattcccca atatcatcta atcaagccat   3240

atttaaattt ctgaagttaa ctccaaattt ctttatagct gattatttca aactaggatc   3300

caattaaagt ttacatatga cacttggtta taactcttta gttggatata acattattat   3360

tattttgata aaatatggaa caaatcaatt ctattaataa gtggtcacat ttgttttggg   3420

cttaaattac tttttaaaga tactggattt tcctaagatt tctgatttac actgatattt   3480

ttttttgtca ttcttaattg catcacacaa tagatgtaaa tgaagatgta gtcacctcag   3540

ataaaattgg tatcgtgtat gataatattg tatcatttat atttgcctta tgttaacttt   3600

aagaaattga tttttttgta ttaatcattt tcccattgca acagagctat attttttcta   3660

ttttaagaat catattttag gattattttt ggcaaataca gtgagcactt atgtaaccag   3720

atgataatga actcaaatgt catgatagct tgcataaatg gtgactctag tagatttgac   3780

tcaagcactt ctagaatcat gcactgaatt caaaagaaaa atcttgctgc tttttgtcca   3840

gggcttgttc tattcaactt ctaatttgaa agctgtacaa agtaatagaa gttccattta   3900

aatatgagtt caaaactgta tttacttttt atgtggccct ctctttaggg gattctaatt   3960

ttacttaggg tctctaagtg cagcataatg ttcctgatgt taacagaaga ctgtattttt   4020

aaagttacaa atttgtatat ggaattaagt aatggcgcta tatacgctgt tgtggggagg   4080

ggggaagaaa aggaggaacc aattaaatag gaccttttaa aaattgttaa ttttgtaaac   4140

tttgcttctc ttataagtta ttgtgattca ttttagttac tgtgttttat tttgaaaata   4200

tttaaatatt gcacttctat aaatagtatg ataaatgcac agacaattgc agtaaattct   4260

tttttaagct aggatatttg aaatgacaac ctttggttaa gtgtgtcaag gttgcaacag   4320

aattttcaca atttttttgt tgtttgcaaa ttgttactaa tattgaagag gtaagggagg   4380

caatgcaaat gatttttaat ctttttttat tatcttttca gcagtttata ttttttgtga   4440

ctttatgcaa ccatattttt actttgtctt gacaactgaa agatgtataa ggttttttgc   4500

cagaaatgta ctgtatacat agttttaagt ataacagatt ttactgatat gtaaaaattt   4560

tgccattaaa ataaatgatt tctcactgag aggaactttt ctaccaggtt ggggcatatg   4620

ggagcttaat atatcatatc taatttaaaa taatttcact gaaataaact ccattgcttt   4680

tacctaattt ttttcttgag atgcttttgt agtttttcag agttttagat gattttatac   4740

aaaatcctct gcctagcact gctctttttg atgttgtagt gacaccattt acattgaatt   4800

aatgcttggt agcctggggc tagatgtgga actccatgga tctgtgttct gactggcacc   4860

tttggaatga aagaaaagtg tgtgctgtcc aaattttttc cccttaattc tttccctcat   4920

cttctcaccc ataatagaaa ttttatttcc attgtgagtt ctgacaagaa tgaaattcca   4980

catacaacat aactgtaaat tgttggtagg tagaagttaa tatttgtggt tcatgtatat   5040

tttgaccaga gtatatttaa gtatataatt tcagcttcct tgatttagaa atatgatata   5100

ataaagaaaa actccattta tcatctgtta                                    5130


<210>  199
<211>  574
<212>  PRT
<213>  Homo sapiens

<400>  199


Met Arg Arg Leu Ser Ser Trp Arg Lys Met Ala Thr Ala Glu Lys Gln 
1               5                   10                  15      


Lys His Asp Gly Arg Val Lys Ile Gly His Tyr Ile Leu Gly Asp Thr 
            20                  25                  30          


Leu Gly Val Gly Thr Phe Gly Lys Val Lys Val Gly Lys His Glu Leu 
        35                  40                  45              


Thr Gly His Lys Val Ala Val Lys Ile Leu Asn Arg Gln Lys Ile Arg 
    50                  55                  60                  


Ser Leu Asp Val Val Gly Lys Ile Arg Arg Glu Ile Gln Asn Leu Lys 
65                  70                  75                  80  


Leu Phe Arg His Pro His Ile Ile Lys Leu Tyr Gln Val Ile Ser Thr 
                85                  90                  95      


Pro Ser Asp Ile Phe Met Val Met Glu Tyr Val Ser Gly Gly Glu Leu 
            100                 105                 110         


Phe Asp Tyr Ile Cys Lys Asn Gly Arg Lys Ser Asp Val Pro Gly Val 
        115                 120                 125             


Val Lys Thr Gly Ser Thr Lys Glu Leu Asp Glu Lys Glu Ser Arg Arg 
    130                 135                 140                 


Leu Phe Gln Gln Ile Leu Ser Gly Val Asp Tyr Cys His Arg His Met 
145                 150                 155                 160 


Val Val His Arg Asp Leu Lys Pro Glu Asn Val Leu Leu Asp Ala His 
                165                 170                 175     


Met Asn Ala Lys Ile Ala Asp Phe Gly Leu Ser Asn Met Met Ser Asp 
            180                 185                 190         


Gly Glu Phe Leu Arg Thr Ser Cys Gly Ser Pro Asn Tyr Ala Ala Pro 
        195                 200                 205             


Glu Val Ile Ser Gly Arg Leu Tyr Ala Gly Pro Glu Val Asp Ile Trp 
    210                 215                 220                 


Ser Ser Gly Val Ile Leu Tyr Ala Leu Leu Cys Gly Thr Leu Pro Phe 
225                 230                 235                 240 


Asp Asp Asp His Val Pro Thr Leu Phe Lys Lys Ile Cys Asp Gly Ile 
                245                 250                 255     


Phe Tyr Thr Pro Gln Tyr Leu Asn Pro Ser Val Ile Ser Leu Leu Lys 
            260                 265                 270         


His Met Leu Gln Val Asp Pro Met Lys Arg Ala Thr Ile Lys Asp Ile 
        275                 280                 285             


Arg Glu His Glu Trp Phe Lys Gln Asp Leu Pro Lys Tyr Leu Phe Pro 
    290                 295                 300                 


Glu Asp Pro Ser Tyr Ser Ser Thr Met Ile Asp Asp Glu Ala Leu Lys 
305                 310                 315                 320 


Glu Val Cys Glu Lys Phe Glu Cys Ser Glu Glu Glu Val Leu Ser Cys 
                325                 330                 335     


Leu Tyr Asn Arg Asn His Gln Asp Pro Leu Ala Val Ala Tyr His Leu 
            340                 345                 350         


Ile Ile Asp Asn Arg Arg Ile Met Asn Glu Ala Lys Asp Phe Tyr Leu 
        355                 360                 365             


Ala Thr Ser Pro Pro Asp Ser Phe Leu Asp Asp His His Leu Thr Arg 
    370                 375                 380                 


Pro His Pro Glu Arg Val Pro Phe Leu Val Ala Glu Thr Pro Arg Ala 
385                 390                 395                 400 


Arg His Thr Leu Asp Glu Leu Asn Pro Gln Lys Ser Lys His Gln Gly 
                405                 410                 415     


Val Arg Lys Ala Lys Trp His Leu Gly Ile Arg Ser Gln Ser Arg Pro 
            420                 425                 430         


Asn Asp Ile Met Ala Glu Val Cys Arg Ala Ile Lys Gln Leu Asp Tyr 
        435                 440                 445             


Glu Trp Lys Val Val Asn Pro Tyr Tyr Leu Arg Val Arg Arg Lys Asn 
    450                 455                 460                 


Pro Val Thr Ser Thr Tyr Ser Lys Met Ser Leu Gln Leu Tyr Gln Val 
465                 470                 475                 480 


Asp Ser Arg Thr Tyr Leu Leu Asp Phe Arg Ser Ile Asp Asp Glu Ile 
                485                 490                 495     


Thr Glu Ala Lys Ser Gly Thr Ala Thr Pro Gln Arg Ser Gly Ser Val 
            500                 505                 510         


Ser Asn Tyr Arg Ser Cys Gln Arg Ser Asp Ser Asp Ala Glu Ala Gln 
        515                 520                 525             


Gly Lys Ser Ser Glu Val Ser Leu Thr Ser Ser Val Thr Ser Leu Asp 
    530                 535                 540                 


Ser Ser Pro Val Asp Leu Thr Pro Arg Pro Gly Ser His Thr Ile Glu 
545                 550                 555                 560 


Phe Phe Glu Met Cys Ala Asn Leu Ile Lys Ile Leu Ala Gln 
                565                 570                 

<210>  200
<211>  1586
<212>  DNA
<213>  Homo sapiens

<400>  200
gcgccccgca ggaagtgctt ccctgggcgg aagcttctga gcgtgatata gcggaagtgc     60

cttctcttcc ggtctttctg gtctcggccg cagaagcgag atgacgaagg gaacgtcatc    120

gtttggaaag cgtcgcaata agacgcacac gttgtgccgc cgctgtggct ctaaggccta    180

ccaccttcag aagtcgacct gtggcaaatg tggctaccct gccaagcgca agagaaagta    240

taactggagt gccaaggcta aaagacgaaa taccaccgga actggtcgaa tgaggcacct    300

aaaaattgta taccgcagat tcaggcatgg attccgtgaa ggaacaacac ctaaacccaa    360

gagggcagct gttgcagcat ccagttcatc ttaagaatgt caacgattag tcatgcaata    420

aatgttctgg ttttaaaaaa tacatatctg gttttggtaa ggtattttta atcaattagg    480

cttgtagtat cagtgaaata ctgtaggttt agggactggg ctagcttcat atcagattta    540

cttgttaagt gactgttttg gaatgtttac ttttggactg ggtttgtaac acggttaaag    600

gcaatgagaa acaagcagaa ttccaggagt ccttgaagca gagggcactg gaagacaata    660

tagcagatta aaatagcaca gctcatgtgg cataggtggg tattttagat gtttgagtaa    720

atttgaaaga gtatgatgtt taaattacct ttagcaacat gttcatctgc tatgctgtca    780

tgactagggg gatgattatt agtcacatag agcttgggag taccactgga aacgtatggg    840

taggagttta ggtggcttct gtttttcaaa agatgatctt atcctagtat ctgtaatgct    900

cacttggcac acctgacttg tgggctgtgt gtaaggtggc tagctaagtg aaaaaagcct    960

gctaggtgtg agtcaactta agaatatgta aataggtttg agaaaaagta gggcttgggt   1020

gcaagtaaag attgagcagg aaataaagga aaatcaagta taatccctga gatttgtaga   1080

ctaaaggcaa tgatgtggga ctacttggtc gaattttttt agccctcaac ttggtaattg   1140

ggtgtttctg tgttaaagca ctgaaacttg ctgtcgtgcc ttcctagttt tcgtggttta   1200

ttgacagggt tgggggtttt ttttgttttt ttaaaatgaa gggacaaagt caactggact   1260

gctgagtgag agggcagggg cagttgaagg gaacatgaat tgctggaaca gctacataaa   1320

atagtgatgt agccaagtca tgctatttaa attataattc tccactgtgt ttagaataac   1380

atctgaggtt cttaacctgg ccttggaagg gtatcacttt tacttgtaac ctggaatggc   1440

tttataatgt gctagctaat tgctactctc atcttgtatt ttaactccta atttaccctt   1500

caggtctcag cttcagaaca ttcacttata aagaaaccct gctgattaaa tctctcttgg   1560

gcttcctccc aaaaaaaaaa aaaaaa                                        1586


<210>  201
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  201


Met Thr Lys Gly Thr Ser Ser Phe Gly Lys Arg Arg Asn Lys Thr His 
1               5                   10                  15      


Thr Leu Cys Arg Arg Cys Gly Ser Lys Ala Tyr His Leu Gln Lys Ser 
            20                  25                  30          


Thr Cys Gly Lys Cys Gly Tyr Pro Ala Lys Arg Lys Arg Lys Tyr Asn 
        35                  40                  45              


Trp Ser Ala Lys Ala Lys Arg Arg Asn Thr Thr Gly Thr Gly Arg Met 
    50                  55                  60                  


Arg His Leu Lys Ile Val Tyr Arg Arg Phe Arg His Gly Phe Arg Glu 
65                  70                  75                  80  


Gly Thr Thr Pro Lys Pro Lys Arg Ala Ala Val Ala Ala Ser Ser Ser 
                85                  90                  95      


Ser 
    

<210>  202
<211>  80
<212>  DNA
<213>  Homo sapiens

<400>  202
agcttatcag tgatgttgta aaaataaatg tctgaacata tgaatgcagt attgatttca     60

gcatttaact gagataagcg                                                 80


<210>  203
<211>  4097
<212>  DNA
<213>  Homo sapiens

<400>  203
attctttttt taacttttac ttattcatta ggatgatttc ataatatatt tcctggttta     60

gaggaaacag gaacaatggc taccgagagt actccctcag agatcataga aagagaaaga    120

aaaaagttgc ttgaaatcct tcaacatgat cctgattcta tcttagacac gttaacttct    180

cggaggctga tttctgagga agagtatgag actctggaga atgttacaga tctcctgaag    240

aaaagtcgga agctgttaat tttggtacag aaaaagggag aggcgacctg tcagcatttt    300

ctcaagtgtt tatttagtac ttttccacag tcagctgcca tttgcggctt aaggcatgaa    360

gttttaaaac atgagaatac agtacctcct caatctatgg gggcaagcag taattcagaa    420

gatgcttttt ctcctggaat aaaacagcct gaagcccctg agatcacagt gttcttcagt    480

gagaaggaac acttggattt ggaaacctct gagtttttca gggacaagaa aactagttat    540

agggaaacag ctttgtctgc caggaagaat gagaaggaat atgacacacc agaagtcaca    600

ttatcatatt cagttgagaa agttggatgt gaagttccag caactattac atatataaaa    660

gatggacaga gatatgagga gctagatgat tctttatact taggaaaaga ggaatatcta    720

ggatctgttg acacccctga agatgcagaa gccactgtgg aagaggaggt ttatgatgac    780

ccagagcacg ttggatatga tggtgaagag gacttcgaga attcagaaac cacagagttc    840

tctggtgaag aaccaagtta tgagggatca gaaaccagcc tttcattgga ggaggaacag    900

gagaaaagta tagaagaaag aaaaaaggtg tttaaagatg tcctgttatg tttgaacatg    960

gatagaagca gaaaggttct gccagatttt gttaaacaat tctccttaga tcgaggatgt   1020

aagtggaccc ctgagagtcc aggagactta gcctggaatt tcctgatgaa agttcaagca   1080

cgagatgtga cggctaggga ttcaatcctc agtcacaagg ttctggatga agatagcaag   1140

gaggatttgc tggctggagt ggagaatttg gaaattcgag acatacaaac cattaatccc   1200

cttgacgtgc tttgtgccac catgctgtgt tcagatagct ctttgcaacg ccaagtcatg   1260

tcaaacatgt atcagtgcca gtttgctctt cccctgctac tgccagatgc agaaaacaac   1320

aaaagcatct taatgctggg ggccatgaaa gacattgtga agaagcagtc aacacagttt   1380

tcaggggggc ctacagagga tacagaaaag tttctgactc tcatgaagat gcctgtcatc   1440

tcttttgtgc gtctaggata ctgtagcttc tctaagtcca gaatcctcaa cacacttctc   1500

agccctgccc agttgaaatt acacaaaatc tttcttcatc aagatttgcc tcttttggtg   1560

cttccccggc aaatctctga tggcctggtt gagataacat ggtgttttcc tgatagcgat   1620

gatagaaagg aaaacccctt tttccaaaag cctgttgctc tggctaatct ccgtggaaat   1680

ctagaaagct tttggactca gtttggtttt ttgatggaag tttcttcagc tgtgtttttt   1740

ttcactgact gtttaggtga gaaggaatgg gacttgctaa tgtttttagg agaggctgcc   1800

attgaaagat gctactttgt tctcagttcc caagccaggg agagtgaaga ggctcaaatt   1860

tttcagagga tactgaactt gaagccagca cagctactgt tttgggagag gggagatgct   1920

ggggatagaa ggaagaacat ggagggcctt caagctgccc tccaggaagt gatgttctct   1980

tcttgcctca gatgtgtgtc tgtggaggat atggccgccc tggccaggga gctggggatt   2040

caggtagatg aagactttga aaacactcag agaattcaag tttcctctgg agaaaacatg   2100

gctgggacag ctgaaggtga gggtcagcaa agacacagtc agctaaaaag ctcatctaaa   2160

agccaggctc taatgccaat tcaagagcct gggactcaat gtgagctcag ccagaatctt   2220

cagaatctct atggtacccc agtattcagg cctgttctag agaactcctg gctctttcca   2280

accagaattg gaggtaactt taaccatgtt tccttgaaag cctcctgggt tatgggccgc   2340

ccctttgggt cagagcagag gcctaagtgg ttccatcctt tgccttttca gaatgcaggg   2400

gcccagggcc gaggtaaaag ttttggtatt caatccttcc atccccagat attttattca   2460

ggtgaaagat tcatgaaatt ttccagagtt gctcggggat gtcactcgaa tggaacattt   2520

gggagactgc caagacccat ttgtcagcat gtacaggcct gccctgagag accacaaatg   2580

atgggaactc ttgaaaggtc tagggcagta gcctccaaga taggtcactc ctattccctg   2640

gattcacagc cagcaagagc agtagggaag ccatggcctc agcaagcttg caccagggta   2700

acagagttaa ctgaagcaac tggaaaactg ataagaacat cccatattgg aaagcctcac   2760

cctcagtcct ttcaaccagc agcagccaca caaaaactaa gacctgcttc tcagcaagga   2820

gtccagatga agacacaagg tggggcttca aatccagctc tccaaatagg gtcccatccc   2880

atgtgcaaga gctctcagtt caaatccgat cagtccaacc catccacagt caaacactcc   2940

cagcctaaac ccttccattc tgtgccctct caacctaaat cctctcagac aaaatcctgt   3000

cagtcccagc cctcccaaac taaaccttct ccatgcaaat ctactcagcc taagccaagc   3060

cagccctggc ctccccagtc taagccttct cagcccagac cccctcaacc taagtcatcc   3120

tcaaccaatc cttcacaagc taaggcacac cactcaaaag cagggcagaa gaggggaggg   3180

aagcattaaa gagctaactc cagagatcta taaagcatat cctttaccca ggccattcct   3240

atcatatagt aagcagaaga gttgccatga aagtaaaaga ctactgtcat tagcatgtaa   3300

aacaaagaaa gatatacatg actgaattgg atatctttgt ttgtttgttt gagacagagt   3360

ttcactcttg ttgcccaggc tggagtgcaa tggcacgatc tcggctcacc gcaacctctg   3420

cttcctggct taaagtgatt ctcctgcctc agcctctcga gtagctggga ttacaggcat   3480

gcaccaccac acccagctaa ttttgtattt ttagtagagg cagggtttct ccatgttggt   3540

caggctggtc ttgaactccc gacctcaggt gatccgccca cctaggcctc tcaaagtgtt   3600

gggattacgt gtgtaagcca cagtgcccag cccgaattgg atatctttaa gatatctgta   3660

agtgttatat ccctaaccaa gaagaaaaat atgaaaataa ttaagactag aatcaagcag   3720

tagataattg aatccaatct tgggtattat tagataatgt ataacttgca cccagggaat   3780

gggggtctat gagacaaccc cacttggaga agaatggggt tagggtctct aattgcaaag   3840

tgactgtaca ataggacgaa agttgcctct gtgtctgaga aagtatctta gttgttggct   3900

gctccagagg tatctttgtc aaaagcttct ggttcaatat cagccactga gcagataacc   3960

ctgcttattt ggtgtggtta aatcaactag cttctgctaa tagccccaat ttgcttgaat   4020

gggaaaactc tctcatttga cccttatagg tagaaataat gaattaacaa ccaataaaat   4080

taatcatttg gcattaa                                                  4097


<210>  204
<211>  1037
<212>  PRT
<213>  Homo sapiens

<400>  204


Met Ala Thr Glu Ser Thr Pro Ser Glu Ile Ile Glu Arg Glu Arg Lys 
1               5                   10                  15      


Lys Leu Leu Glu Ile Leu Gln His Asp Pro Asp Ser Ile Leu Asp Thr 
            20                  25                  30          


Leu Thr Ser Arg Arg Leu Ile Ser Glu Glu Glu Tyr Glu Thr Leu Glu 
        35                  40                  45              


Asn Val Thr Asp Leu Leu Lys Lys Ser Arg Lys Leu Leu Ile Leu Val 
    50                  55                  60                  


Gln Lys Lys Gly Glu Ala Thr Cys Gln His Phe Leu Lys Cys Leu Phe 
65                  70                  75                  80  


Ser Thr Phe Pro Gln Ser Ala Ala Ile Cys Gly Leu Arg His Glu Val 
                85                  90                  95      


Leu Lys His Glu Asn Thr Val Pro Pro Gln Ser Met Gly Ala Ser Ser 
            100                 105                 110         


Asn Ser Glu Asp Ala Phe Ser Pro Gly Ile Lys Gln Pro Glu Ala Pro 
        115                 120                 125             


Glu Ile Thr Val Phe Phe Ser Glu Lys Glu His Leu Asp Leu Glu Thr 
    130                 135                 140                 


Ser Glu Phe Phe Arg Asp Lys Lys Thr Ser Tyr Arg Glu Thr Ala Leu 
145                 150                 155                 160 


Ser Ala Arg Lys Asn Glu Lys Glu Tyr Asp Thr Pro Glu Val Thr Leu 
                165                 170                 175     


Ser Tyr Ser Val Glu Lys Val Gly Cys Glu Val Pro Ala Thr Ile Thr 
            180                 185                 190         


Tyr Ile Lys Asp Gly Gln Arg Tyr Glu Glu Leu Asp Asp Ser Leu Tyr 
        195                 200                 205             


Leu Gly Lys Glu Glu Tyr Leu Gly Ser Val Asp Thr Pro Glu Asp Ala 
    210                 215                 220                 


Glu Ala Thr Val Glu Glu Glu Val Tyr Asp Asp Pro Glu His Val Gly 
225                 230                 235                 240 


Tyr Asp Gly Glu Glu Asp Phe Glu Asn Ser Glu Thr Thr Glu Phe Ser 
                245                 250                 255     


Gly Glu Glu Pro Ser Tyr Glu Gly Ser Glu Thr Ser Leu Ser Leu Glu 
            260                 265                 270         


Glu Glu Gln Glu Lys Ser Ile Glu Glu Arg Lys Lys Val Phe Lys Asp 
        275                 280                 285             


Val Leu Leu Cys Leu Asn Met Asp Arg Ser Arg Lys Val Leu Pro Asp 
    290                 295                 300                 


Phe Val Lys Gln Phe Ser Leu Asp Arg Gly Cys Lys Trp Thr Pro Glu 
305                 310                 315                 320 


Ser Pro Gly Asp Leu Ala Trp Asn Phe Leu Met Lys Val Gln Ala Arg 
                325                 330                 335     


Asp Val Thr Ala Arg Asp Ser Ile Leu Ser His Lys Val Leu Asp Glu 
            340                 345                 350         


Asp Ser Lys Glu Asp Leu Leu Ala Gly Val Glu Asn Leu Glu Ile Arg 
        355                 360                 365             


Asp Ile Gln Thr Ile Asn Pro Leu Asp Val Leu Cys Ala Thr Met Leu 
    370                 375                 380                 


Cys Ser Asp Ser Ser Leu Gln Arg Gln Val Met Ser Asn Met Tyr Gln 
385                 390                 395                 400 


Cys Gln Phe Ala Leu Pro Leu Leu Leu Pro Asp Ala Glu Asn Asn Lys 
                405                 410                 415     


Ser Ile Leu Met Leu Gly Ala Met Lys Asp Ile Val Lys Lys Gln Ser 
            420                 425                 430         


Thr Gln Phe Ser Gly Gly Pro Thr Glu Asp Thr Glu Lys Phe Leu Thr 
        435                 440                 445             


Leu Met Lys Met Pro Val Ile Ser Phe Val Arg Leu Gly Tyr Cys Ser 
    450                 455                 460                 


Phe Ser Lys Ser Arg Ile Leu Asn Thr Leu Leu Ser Pro Ala Gln Leu 
465                 470                 475                 480 


Lys Leu His Lys Ile Phe Leu His Gln Asp Leu Pro Leu Leu Val Leu 
                485                 490                 495     


Pro Arg Gln Ile Ser Asp Gly Leu Val Glu Ile Thr Trp Cys Phe Pro 
            500                 505                 510         


Asp Ser Asp Asp Arg Lys Glu Asn Pro Phe Phe Gln Lys Pro Val Ala 
        515                 520                 525             


Leu Ala Asn Leu Arg Gly Asn Leu Glu Ser Phe Trp Thr Gln Phe Gly 
    530                 535                 540                 


Phe Leu Met Glu Val Ser Ser Ala Val Phe Phe Phe Thr Asp Cys Leu 
545                 550                 555                 560 


Gly Glu Lys Glu Trp Asp Leu Leu Met Phe Leu Gly Glu Ala Ala Ile 
                565                 570                 575     


Glu Arg Cys Tyr Phe Val Leu Ser Ser Gln Ala Arg Glu Ser Glu Glu 
            580                 585                 590         


Ala Gln Ile Phe Gln Arg Ile Leu Asn Leu Lys Pro Ala Gln Leu Leu 
        595                 600                 605             


Phe Trp Glu Arg Gly Asp Ala Gly Asp Arg Arg Lys Asn Met Glu Gly 
    610                 615                 620                 


Leu Gln Ala Ala Leu Gln Glu Val Met Phe Ser Ser Cys Leu Arg Cys 
625                 630                 635                 640 


Val Ser Val Glu Asp Met Ala Ala Leu Ala Arg Glu Leu Gly Ile Gln 
                645                 650                 655     


Val Asp Glu Asp Phe Glu Asn Thr Gln Arg Ile Gln Val Ser Ser Gly 
            660                 665                 670         


Glu Asn Met Ala Gly Thr Ala Glu Gly Glu Gly Gln Gln Arg His Ser 
        675                 680                 685             


Gln Leu Lys Ser Ser Ser Lys Ser Gln Ala Leu Met Pro Ile Gln Glu 
    690                 695                 700                 


Pro Gly Thr Gln Cys Glu Leu Ser Gln Asn Leu Gln Asn Leu Tyr Gly 
705                 710                 715                 720 


Thr Pro Val Phe Arg Pro Val Leu Glu Asn Ser Trp Leu Phe Pro Thr 
                725                 730                 735     


Arg Ile Gly Gly Asn Phe Asn His Val Ser Leu Lys Ala Ser Trp Val 
            740                 745                 750         


Met Gly Arg Pro Phe Gly Ser Glu Gln Arg Pro Lys Trp Phe His Pro 
        755                 760                 765             


Leu Pro Phe Gln Asn Ala Gly Ala Gln Gly Arg Gly Lys Ser Phe Gly 
    770                 775                 780                 


Ile Gln Ser Phe His Pro Gln Ile Phe Tyr Ser Gly Glu Arg Phe Met 
785                 790                 795                 800 


Lys Phe Ser Arg Val Ala Arg Gly Cys His Ser Asn Gly Thr Phe Gly 
                805                 810                 815     


Arg Leu Pro Arg Pro Ile Cys Gln His Val Gln Ala Cys Pro Glu Arg 
            820                 825                 830         


Pro Gln Met Met Gly Thr Leu Glu Arg Ser Arg Ala Val Ala Ser Lys 
        835                 840                 845             


Ile Gly His Ser Tyr Ser Leu Asp Ser Gln Pro Ala Arg Ala Val Gly 
    850                 855                 860                 


Lys Pro Trp Pro Gln Gln Ala Cys Thr Arg Val Thr Glu Leu Thr Glu 
865                 870                 875                 880 


Ala Thr Gly Lys Leu Ile Arg Thr Ser His Ile Gly Lys Pro His Pro 
                885                 890                 895     


Gln Ser Phe Gln Pro Ala Ala Ala Thr Gln Lys Leu Arg Pro Ala Ser 
            900                 905                 910         


Gln Gln Gly Val Gln Met Lys Thr Gln Gly Gly Ala Ser Asn Pro Ala 
        915                 920                 925             


Leu Gln Ile Gly Ser His Pro Met Cys Lys Ser Ser Gln Phe Lys Ser 
    930                 935                 940                 


Asp Gln Ser Asn Pro Ser Thr Val Lys His Ser Gln Pro Lys Pro Phe 
945                 950                 955                 960 


His Ser Val Pro Ser Gln Pro Lys Ser Ser Gln Thr Lys Ser Cys Gln 
                965                 970                 975     


Ser Gln Pro Ser Gln Thr Lys Pro Ser Pro Cys Lys Ser Thr Gln Pro 
            980                 985                 990         


Lys Pro Ser Gln Pro Trp Pro Pro  Gln Ser Lys Pro Ser  Gln Pro Arg 
        995                 1000                 1005             


Pro Pro  Gln Pro Lys Ser Ser  Ser Thr Asn Pro Ser  Gln Ala Lys 
    1010                 1015                 1020             


Ala His  His Ser Lys Ala Gly  Gln Lys Arg Gly Gly  Lys His 
    1025                 1030                 1035         

<210>  205
<211>  5382
<212>  DNA
<213>  Homo sapiens

<400>  205
gcagccgcgg cggcggtggc acagcagcgg gcagcggcgg ctcagggagc tggagcctca     60

acagcctcca gcgagcccgg gacccgccga cagcccgaga aaccagccga aggacgcggg    120

gcggggtcgc cgccgccgcc acggggtgct ccctccctcc cgcccaagtc cggccacctg    180

gtcttcccct cggccccggc cgtctcagac tcatcaaaat gaaaccagga ggcttttggc    240

tgcatctcac actgctcgga gcctccctgc cggctgcgct gggatggatg gacccaggaa    300

ccagcagagg cccggatgtg ggtgtggggg agtcacaggc agaggagccc agaagctttg    360

aagtcacaag aagagaaggg ctttccagcc acaacgagct gctggcctcc tgcgggaaga    420

agttctgcag ccgagggagc cggtgcgtgc tcagcaggaa gacaggggag cccgaatgcc    480

agtgcctgga ggcatgcagg cccagctacg tgcctgtgtg cggctctgat gggaggtttt    540

atgaaaacca ctgtaagctc caccgtgctg cttgcctcct gggaaagagg atcaccgtca    600

tccacagcaa ggactgtttc ctcaaaggtg acacgtgcac catggccggc tacgcccgct    660

tgaagaatgt ccttctggca ctccagaccc gtctgcagcc actccaagaa ggagacagca    720

gacaagaccc tgcctcccag aagcgcctcc tggtggaatc tctgttcagg gacttagatg    780

cagatggcaa tggccacctc agcagctccg aactggctca gcatgtgctg aagaagcagg    840

acctggatga agacttactt ggttgctcac caggtgacct cctccgattt gacgattaca    900

acagtgacag ctccctgacc ctccgcgagt tctacatggc cttccaagtg gttcagctca    960

gcctcgcccc cgaggacagg gtcagtgtga ccacagtgac cgtggggctg agcacagtgc   1020

tgacctgcgc cgtccatgga gacctgaggc caccaatcat ctggaagcgc aacgggctca   1080

ccctgaactt cctggacttg gaagacatca atgactttgg agaggatgat tccctgtaca   1140

tcaccaaggt gaccaccatc cacatgggca attacacctg ccatgcttcc ggccacgagc   1200

agctgttcca gacccacgtc ctgcaggtga atgtgccgcc agtcatccgt gtctatccag   1260

agagccaggc acaggagcct ggagtggcag ccagcctaag atgccatgct gagggcattc   1320

ccatgcccag aatcacttgg ctgaaaaacg gcgtggatgt ctcaactcag atgtccaaac   1380

agctctccct tttagccaat gggagcgaac tccacatcag cagtgttcgg tatgaagaca   1440

caggggcata cacctgcatt gccaaaaatg aagtgggtgt ggatgaagat atctcctcgc   1500

tcttcattga agactcagct agaaagaccc ttgcaaacat cctgtggcga gaggaaggcc   1560

tcagcgtggg aaacatgttc tatgtcttct ccgacgacgg tatcatcgtc atccatcctg   1620

tggactgtga gatccagagg cacctcaaac ccacggaaaa gattttcatg agctatgaag   1680

aaatctgtcc tcaaagagaa aaaaatgcaa cccagccctg ccagtgggta tctgcagtca   1740

atgtccggaa ccggtacatc tatgtggccc agccagcact gagcagagtc cttgtggtcg   1800

acatccaagc ccagaaagtc ctacagtcca taggtgtgga ccctctgccg gctaagctgt   1860

cctatgacaa gtcacatgac caagtgtggg tcctgagctg gggggacgtg cacaagtccc   1920

gaccaagtct ccaggtgatc acagaagcca gcaccggcca gagccagcac ctcatccgca   1980

caccctttgc aggagtggat gatttcttca ttcccccaac aaacctcatc atcaaccaca   2040

tcaggtttgg cttcatcttc aacaagtctg atcctgcagt ccacaaggtg gacctggaaa   2100

caatgatgcc cctcaagacc atcggcctgc accaccatgg ctgcgtgccc caggccatgg   2160

cacacaccca cctgggcggc tacttcttca tccagtgccg acaggacagc cccgcctctg   2220

ctgcccgaca gctgctcgtt gacagtgtca cagactctgt gcttggcccc aatggtgatg   2280

taacaggcac cccacacaca tcccccgacg ggcgcttcat agtcagtgct gcagctgaca   2340

gcccctggct gcacgtgcag gagatcacag tgcggggcga gatccagacc ctgtatgacc   2400

tgcaaataaa ctcgggcatc tcagacttgg ccttccagcg ctccttcact gaaagcaatc   2460

aatacaacat ctacgcggct ctgcacacgg agccggacct gctgttcctg gagctgtcca   2520

cggggaaggt gggcatgctg aagaacttaa aggagccacc cgcagggcca gctcagccct   2580

gggggggtac ccacagaatc atgagggaca gtgggctgtt tggacagtac ctcctcacac   2640

cagcccgaga gtcactgttc ctcatcaatg ggagacaaaa cacgctgcgg tgtgaggtgt   2700

caggtataaa gggggggacc acagtggtgt gggtgggtga ggtatgaagg gcccagagca   2760

gagccctggg ccaaggaaca ccccctagtc ctgacactgc agcctcaagc aggtacgctg   2820

tacattttta cagacaaaag caaaaacctg tactcgcttt gtggttcaac actggtctcc   2880

ttgcaagttt cctagtataa ggtatgcgct gctaccaaga ttggggtttt ttcgttagga   2940

agtatgattt atgccttgag ctacgatgag aacatatgct gctgtgtaaa gggatcattt   3000

ctgtgccaag ctgcacaccg agtgacctgg ggacatcatg gaaccaaggg atcctgctct   3060

ccaagcagac acctctgtca gttgccttca catagtcatt gtcccttact gccagaccca   3120

gccagacttt gccctgacgg agtggcccgg aagcagaggc cgaccaggag caggggcctc   3180

cctcccgaac tgaaagccca tccgtcctcg cgtgggaccg catcttctcc ctcgcagctg   3240

cttcttgctt ttctttccat ttgacttgct gtaagcctga gggagagcca acaagactta   3300

ctgcatcttg ggggatgggg aaatcactca ctttattttg gaaatttttg attaaaaaaa   3360

aattttataa tctcaaatgc tagtaagcag aaagatgctc tccgaggtcc aactatatcc   3420

ttccctgcct taggccgagt ctcgggggtg gtcacaaccc cacatcccac agccagaaag   3480

aacaatggtc atctgagaat actggccctg tcgactattg ccaccctgct tctccaagag   3540

cagaccaggc cacctcatcc gtaaggactc ggttctgtgt tgggacccca aaaaaccaga   3600

acaagttctg tgtgcctcct ttcagcacag aagggagaca tctcattagt caggtctggt   3660

accccagatt cagggcagac tgggcttgcc tggcaaggta tgggtggcct ccaggctcaa   3720

tgcagaaacc ccaaggacac gagtggggcc aggtgagttc ctgaagctat accttttcaa   3780

aacagatttt gttttcctac ctgtggccca tccactcctc tctggtaccc catccccgca   3840

tcagcactgc agagagaaca catttcggcg agggttttct tacccacatt ccccaatcaa   3900

tacacacaca ctgcagaacc cagaacagaa ggccacaggc tggcactact gcattctcct   3960

tatgtgtctc aggctgtggt gactctcaca tgggcatcga agaagtacaa cccacatagc   4020

cctctggaga ccgcctagat cagagactca gcaaaaacag gctcgccttc cctctcccac   4080

atatgagtgg aacttacatg tgtcctggtt tgaatgatca ttttgcaagc cacacgggtt   4140

gggagaggtg gtctcaccac agacgtcttt gctaatttgg ccaccttcac ctactgacat   4200

gaccaggatt ttcctttgcc attaaggaat gaactctttc aaggagagga aaccctagac   4260

tctgtgtcac tctcaacaca cacagctcct ttcactcctg cctgactgcc aagccacctg   4320

catcccccgc cccagatctc atgagatcaa tcacttgtat gtctcacgca acttggtcca   4380

ccaaacgcct gtcccctgta actcctaggg gtgcgcctag acaggtacgt ctgtttttta   4440

ttttaaaaga tatgctatgt agatataagt tgaggaagct cacctcaaaa gcctagaatg   4500

cagtttcaca gtagctggga tgcatggatg acccatctca cccctttttt tttcctgcct   4560

caatatcttg atatgttatg tttactccca atctcccatt tttaccacta aaattctcca   4620

actttcataa actttttttt ggaaaaattt ccattgtatc agcccctgac agaaaaagga   4680

tctctgagcc taaaggagga aaagtcccac caactaccag accagaacac gagcccctct   4740

gggcagcagg attcctaagt caaagaccag tttgacccaa actggccttt taaaataatc   4800

aggagtgaca gagtcaactt ctgcagcacc tgcttctccc ccactgtccc ttccatcttg   4860

gaatgtgtct aaaaaagcat agctgccctt tgctgtcctc agagtgcatt tcctggagac   4920

ggcaggctta ggtctcactg acagcatgcc agacacaact gaatcgaagc aggcctgaag   4980

cctaggtcag ggtttcagga gtccagcccc aggaggcaaa gtcaccaatg cagggaggta   5040

aatgcctttt ggcaggaaaa ccaatagagt tggttgggtg gggagtcagg ggtgggagga   5100

gaaggaggaa gaggaggaag gccagactgg cctgcccttt ctcccatact tcaccccagc   5160

agaggttcat gggacacagt tggaaagcca ctgggaggaa atgcctcact acaggggggc   5220

ctcctgtagc aagcccagcc ggtaatcctc ctaatgaacc cacaaggtca attcacaact   5280

gatatcttag ctattaaaga agtactgact ttaccaaaag aatcatcaag aaagctattt   5340

atataaaccc cctcagtcat tttgaaataa aattaatttt ac                      5382


<210>  206
<211>  842
<212>  PRT
<213>  Homo sapiens

<400>  206


Met Lys Pro Gly Gly Phe Trp Leu His Leu Thr Leu Leu Gly Ala Ser 
1               5                   10                  15      


Leu Pro Ala Ala Leu Gly Trp Met Asp Pro Gly Thr Ser Arg Gly Pro 
            20                  25                  30          


Asp Val Gly Val Gly Glu Ser Gln Ala Glu Glu Pro Arg Ser Phe Glu 
        35                  40                  45              


Val Thr Arg Arg Glu Gly Leu Ser Ser His Asn Glu Leu Leu Ala Ser 
    50                  55                  60                  


Cys Gly Lys Lys Phe Cys Ser Arg Gly Ser Arg Cys Val Leu Ser Arg 
65                  70                  75                  80  


Lys Thr Gly Glu Pro Glu Cys Gln Cys Leu Glu Ala Cys Arg Pro Ser 
                85                  90                  95      


Tyr Val Pro Val Cys Gly Ser Asp Gly Arg Phe Tyr Glu Asn His Cys 
            100                 105                 110         


Lys Leu His Arg Ala Ala Cys Leu Leu Gly Lys Arg Ile Thr Val Ile 
        115                 120                 125             


His Ser Lys Asp Cys Phe Leu Lys Gly Asp Thr Cys Thr Met Ala Gly 
    130                 135                 140                 


Tyr Ala Arg Leu Lys Asn Val Leu Leu Ala Leu Gln Thr Arg Leu Gln 
145                 150                 155                 160 


Pro Leu Gln Glu Gly Asp Ser Arg Gln Asp Pro Ala Ser Gln Lys Arg 
                165                 170                 175     


Leu Leu Val Glu Ser Leu Phe Arg Asp Leu Asp Ala Asp Gly Asn Gly 
            180                 185                 190         


His Leu Ser Ser Ser Glu Leu Ala Gln His Val Leu Lys Lys Gln Asp 
        195                 200                 205             


Leu Asp Glu Asp Leu Leu Gly Cys Ser Pro Gly Asp Leu Leu Arg Phe 
    210                 215                 220                 


Asp Asp Tyr Asn Ser Asp Ser Ser Leu Thr Leu Arg Glu Phe Tyr Met 
225                 230                 235                 240 


Ala Phe Gln Val Val Gln Leu Ser Leu Ala Pro Glu Asp Arg Val Ser 
                245                 250                 255     


Val Thr Thr Val Thr Val Gly Leu Ser Thr Val Leu Thr Cys Ala Val 
            260                 265                 270         


His Gly Asp Leu Arg Pro Pro Ile Ile Trp Lys Arg Asn Gly Leu Thr 
        275                 280                 285             


Leu Asn Phe Leu Asp Leu Glu Asp Ile Asn Asp Phe Gly Glu Asp Asp 
    290                 295                 300                 


Ser Leu Tyr Ile Thr Lys Val Thr Thr Ile His Met Gly Asn Tyr Thr 
305                 310                 315                 320 


Cys His Ala Ser Gly His Glu Gln Leu Phe Gln Thr His Val Leu Gln 
                325                 330                 335     


Val Asn Val Pro Pro Val Ile Arg Val Tyr Pro Glu Ser Gln Ala Gln 
            340                 345                 350         


Glu Pro Gly Val Ala Ala Ser Leu Arg Cys His Ala Glu Gly Ile Pro 
        355                 360                 365             


Met Pro Arg Ile Thr Trp Leu Lys Asn Gly Val Asp Val Ser Thr Gln 
    370                 375                 380                 


Met Ser Lys Gln Leu Ser Leu Leu Ala Asn Gly Ser Glu Leu His Ile 
385                 390                 395                 400 


Ser Ser Val Arg Tyr Glu Asp Thr Gly Ala Tyr Thr Cys Ile Ala Lys 
                405                 410                 415     


Asn Glu Val Gly Val Asp Glu Asp Ile Ser Ser Leu Phe Ile Glu Asp 
            420                 425                 430         


Ser Ala Arg Lys Thr Leu Ala Asn Ile Leu Trp Arg Glu Glu Gly Leu 
        435                 440                 445             


Ser Val Gly Asn Met Phe Tyr Val Phe Ser Asp Asp Gly Ile Ile Val 
    450                 455                 460                 


Ile His Pro Val Asp Cys Glu Ile Gln Arg His Leu Lys Pro Thr Glu 
465                 470                 475                 480 


Lys Ile Phe Met Ser Tyr Glu Glu Ile Cys Pro Gln Arg Glu Lys Asn 
                485                 490                 495     


Ala Thr Gln Pro Cys Gln Trp Val Ser Ala Val Asn Val Arg Asn Arg 
            500                 505                 510         


Tyr Ile Tyr Val Ala Gln Pro Ala Leu Ser Arg Val Leu Val Val Asp 
        515                 520                 525             


Ile Gln Ala Gln Lys Val Leu Gln Ser Ile Gly Val Asp Pro Leu Pro 
    530                 535                 540                 


Ala Lys Leu Ser Tyr Asp Lys Ser His Asp Gln Val Trp Val Leu Ser 
545                 550                 555                 560 


Trp Gly Asp Val His Lys Ser Arg Pro Ser Leu Gln Val Ile Thr Glu 
                565                 570                 575     


Ala Ser Thr Gly Gln Ser Gln His Leu Ile Arg Thr Pro Phe Ala Gly 
            580                 585                 590         


Val Asp Asp Phe Phe Ile Pro Pro Thr Asn Leu Ile Ile Asn His Ile 
        595                 600                 605             


Arg Phe Gly Phe Ile Phe Asn Lys Ser Asp Pro Ala Val His Lys Val 
    610                 615                 620                 


Asp Leu Glu Thr Met Met Pro Leu Lys Thr Ile Gly Leu His His His 
625                 630                 635                 640 


Gly Cys Val Pro Gln Ala Met Ala His Thr His Leu Gly Gly Tyr Phe 
                645                 650                 655     


Phe Ile Gln Cys Arg Gln Asp Ser Pro Ala Ser Ala Ala Arg Gln Leu 
            660                 665                 670         


Leu Val Asp Ser Val Thr Asp Ser Val Leu Gly Pro Asn Gly Asp Val 
        675                 680                 685             


Thr Gly Thr Pro His Thr Ser Pro Asp Gly Arg Phe Ile Val Ser Ala 
    690                 695                 700                 


Ala Ala Asp Ser Pro Trp Leu His Val Gln Glu Ile Thr Val Arg Gly 
705                 710                 715                 720 


Glu Ile Gln Thr Leu Tyr Asp Leu Gln Ile Asn Ser Gly Ile Ser Asp 
                725                 730                 735     


Leu Ala Phe Gln Arg Ser Phe Thr Glu Ser Asn Gln Tyr Asn Ile Tyr 
            740                 745                 750         


Ala Ala Leu His Thr Glu Pro Asp Leu Leu Phe Leu Glu Leu Ser Thr 
        755                 760                 765             


Gly Lys Val Gly Met Leu Lys Asn Leu Lys Glu Pro Pro Ala Gly Pro 
    770                 775                 780                 


Ala Gln Pro Trp Gly Gly Thr His Arg Ile Met Arg Asp Ser Gly Leu 
785                 790                 795                 800 


Phe Gly Gln Tyr Leu Leu Thr Pro Ala Arg Glu Ser Leu Phe Leu Ile 
                805                 810                 815     


Asn Gly Arg Gln Asn Thr Leu Arg Cys Glu Val Ser Gly Ile Lys Gly 
            820                 825                 830         


Gly Thr Thr Val Val Trp Val Gly Glu Val 
        835                 840         

<210>  207
<211>  5260
<212>  DNA
<213>  Homo sapiens

<400>  207
atggtgtttt ctaggagagg gggcctggga gcccgggatc tgcttctttg gcttctgctc     60

ctcgcagcct gggaggtggg gagcggccag ctccactact cgatcccgga ggaagccaaa    120

cacggcacct tcgttggccg cgttgctcag gacctgggac tggagctggc ggagctggtg    180

cctcgcctgt tccgggtggc gtccaaaaca cacagggacc ttctggaggt aaatctgcag    240

aatggcattt tgtttgtgaa ttctcggatc gatcgcgagg agctgtgcca gtggagcgcg    300

gagtgcagca tccacctgga gttgatcgcc gacaggccgc tgcaggtttt ccatgtggag    360

gtgaaggtga aagacattaa cgataatcca cccgtcttca ggggcagaga acaaataata    420

tttattcctg aatctagact cctgaattcg cgttttccga tagaaggagc tgctgatgca    480

gacattggtg ctaacgctct tctaacgtac acgctcagcc cgagtgatta tttctctttg    540

gatgtagagg caagtgatga actgagtaaa tctctttggc ttgaattgag aaaatatttg    600

gatagagaag aaacaccaga acttcactta ttactgactg ccactgatgg gggcaaaccg    660

gagctgcaag gtacagttga gctgctgatc accgtcctcg acgttaatga taacgcccca    720

ctgtttgacc aggccgtata cagagtccac ttgttagaga ctacagcaaa tggaacatta    780

gtgaccacat taaatgcctc tgatgctgac gaaggtgtaa atggtgaagt cgtcttttcc    840

tttgacagtg gtatttctcg tgacattcaa gaaaaattca aagttgattc cagctcagga    900

gaaattaggt taattgataa actggattat gaagaaacaa aatcctacga aattcaagta    960

aaggcagttg ataaaggaag tcctccgatg tcaaatcact gtaaggtttt ggtgaaagtg   1020

ctggatgtaa atgataatgc tccagaactg gcggtcactt cattgtattt gcctatcaga   1080

gaggacgctc cactcagcac cgtcatcgcc ctcatcaccg tgtctgaccg tgactcaggt   1140

gccaacgggc aggtgacttg ctccttaatg ccccacgtcc ccttcaagct ggtgtccacc   1200

ttcaagaatt actactcgtt ggtgttggac agcgccctgg atcgcgagag cctgtcggtc   1260

tatgagctgg tggtgaccgc gcgggacggg ggctcgcctt cgctgtgggc cacggccagg   1320

gtgtccgtgg aggtggccga cgtgaatgac aacgcgcctg cgttcgcgca gcccgagtac   1380

acagtattcg tgaaggagaa caacccgccg ggctgccaca tcttcacggt gtctgcgcgg   1440

gacgcggacg cgcaggagaa cgcgctggtg tcctattcgc tggtggaacg gcgggtgggc   1500

gagcgcgcgc tgtcgaacta cgtgtcagtg cacgcggaga gcggcaaggt gtacgcactg   1560

cagcccctgg accacgagga gctggagctg ctgcagttcc aggtgagcgc gcgggatgcg   1620

ggcgtgccgc ctctgggcag caacgtgacg ctgcaggtgt tcgtgctgga cgagaacgac   1680

aacgcgccgg cgctgctggc gcctcgagtg ggtggcacta ttggtgcagt cagtgagctg   1740

gtgccgcgat tggtgggtgc gggtcatgtg gtggcgaagg tgcgcgcagt ggacgccgac   1800

tcgggctaca acgcgtggct gtcctatgaa ctgcagccgg cagcaggcgg cgcgcgcatc   1860

ccgttccgcg tggggctgta cacgggcgag atcagcacga ctcgtgtcct ggacgaggct   1920

gacttgtcgc gctaccgcct tctggtgcta gtgaaggatc acggtgagcc ggcgctgaca   1980

gccacggcca ctgtgcttgt atctctggtg gagagcggcc aggcgccaaa ggcgtcttcg   2040

cgggcgtcgg tgggtgtcgc gggcccagag gcggcgctgg tggatgtcaa cgtgtacctg   2100

atcatcgcca tctgcgcggt gtccagcctg ctggtgctca cactgctgct gtacacggcg   2160

ctgcggtgct cagtgccgcc cactgagggt gcgtatgtgc cgggcaagcc cactctggtg   2220

tgctccagcg cgttggggag ctggtcgaac tcacagcaga ggcggcagag ggtgtgctct   2280

agcgagggcc cacccaagac cgacctcatg gccttcagcc caggcctatc tccaagtctt   2340

aacacgtcag aaagaaatga acaaccagaa gcaaatttgg atctttctgg taatccacga   2400

cagcccaacc ctgactggcg ttactctgcc tccctgagag caggcatgca cagctctgtg   2460

cacctagagg aggctggcat tctacgggct ggtccaggag ggcctgatca gcagtggcca   2520

acagtatcca gtgcaacacc agaaccagag gcaggagaag tgtcccctcc agtcggtgcg   2580

ggtgtcaaca gcaacagctg gacctttaaa tacggaccag gcaaccccaa acaatccggt   2640

cccggtgagt tgcccgacaa attcattatc ccaggatctc ctgcaatcat ctccatccgg   2700

caggagccta ctaacagcca aattgacaaa agtgacttca taaccttcgg caaaaaggag   2760

gagaccaaga aaaagaagaa aaagaagaag ggtaacaaga cccaggagaa aaaagagaaa   2820

gggaacagca cgactgacaa cagtgaccag tgaggtcctc aaatggaaac aagccactta   2880

gccagttttt gtaataatgg caaatctctc ccatgtagca attccctgct cctttttcct   2940

atctacatga gccctcttag agacctcaga aatctgcaga aagttccctg tgtctgtcta   3000

gaacgcattt aacaggtttt gtcgtaaaag ctttactaag tctggtgtta actctttctc   3060

tccactctgg cttgttttca gaacctaaaa agcagaccca agtttccttt ctcctccgcc   3120

gcaaaggaga ggcttcccag ccccgccagt gagaggttgg actctctgcc ctgtgctccg   3180

gggatcctgt cttgatgaca cttgcagggc aggctgaaaa gttttgagat tgagcagctt   3240

gggagtttgt ggccactggg tatgtgtggc taccgcgggt atgcgagtgc cagatattgg   3300

ctgagacgag ccagcttaga ctaattggta caaggaaggc aagaaaacaa agacaaataa   3360

acagcggaag ttatcagtat ggaggggaag tgtaaactta aagggaccag actttctaaa   3420

tcttacaact caagaggtgg cagccaccct ctaggagaca aaactacccc cactgacaag   3480

gctttaggag accctaaagt ctgttggctg tgacgtcatt atacctaaaa tctgcatcat   3540

acctgcaagc caacagttca gtgttttaac agagaaccac cctgggaaac agaagcagat   3600

ctgatgtgtt tcctatacat gtcctgtgct cactttatta aaaattcttt tgcacacaat   3660

gtttatgaaa aggccagatc cttttccaat acttatgcaa aagcaaaaga aaaccccgac   3720

acctcacctt tcgctgtttg ttgtttcata gatttattta aaaaaagaga aagtctatag   3780

ctataaatct ttaaagagaa atatgaatac aattccccta aactctcctc aaaagagaat   3840

tcagtctaca gccatttaaa tgatcattgc tgctacagaa gtgctttaag agaattgcct   3900

gaaacatctg tattatatcg gccacctgcc aatcacagct ttactctttc aggtcactct   3960

ggggctgcct cttgcatgta ttactaaata aaatgatctc tctttctctc tctctctctc   4020

ttttctaaga aacaattatg tgcactttga tacacaacct tctctaacca actatatatc   4080

aagacccaaa aattgaagaa aaatattgtt ttctcataca gtgagcagat ttttcaatct   4140

actaattctg tgacttgtct tggtgtgcta gcctacacct tctctttggt ttagttttcc   4200

ttttctataa cactctgaat tgctaatctt actaacacct atgatgttac ctgaaatcaa   4260

tctcccatat gtatgctgta tgctatgcta agactcctga aatatactta ctctgtgctt   4320

gtgtatgtga atgttaatgc aactattacc tagagtgaac tttaagcttt attgttgaat   4380

gtaattccat tatatttcct tttgtacacc tgtgaaaaag tggagtagtg tttttttaac   4440

cattgttaat cagcttttgt gtatgaaaga cacagtaaaa tttctttctt aaatcaagat   4500

actggtgatt caaggaattt tatttatggt ccagccaaga gccatctcgt gccaagactt   4560

ctgctggcaa gggaatggat aaagctgttt tgttctagta acaattttgg aatgaatact   4620

gacaatattc catgagggtg tgcaagcaca aattttacca atctgacctc tttgaagttg   4680

cagaatgctt tgaaattcta atggtatctg aaatatcagc tcatagaaag taacaaaatt   4740

tgctgtcacc ttaaataaga cattttaatt ttgttataat gtacaattta gaagtttgat   4800

taattatatt atctatttag gcattaatat aaaagaggta ggagtctgtt atttaaaaaa   4860

agcattaaat ttaaaaaaaa actgtcttgt ctacttttag cttcattctc ccatattttg   4920

aagggtgtgt aacttcagct ctgcaggatt gcatggggta aaacttgtta ccaacacatg   4980

tgaaccattg ctacattgta ggttgtgatc attttgcccc actgaagccc atgtatctga   5040

ccttacgtgc cttttgaact aggagaatcg ggctaattta ttaatgatga taattataat   5100

gtatctgtac agcacttttt acatttgcga agtgctttcc aatccatgtt agttactagt   5160

tattacagct gtaaggataa aacacgtcat gtggattcat tttgaattgg tgctattggt   5220

atttcctctg ttattgctaa taaatgaaaa tggtggtatg                         5260


<210>  208
<211>  950
<212>  PRT
<213>  Homo sapiens

<400>  208


Met Val Phe Ser Arg Arg Gly Gly Leu Gly Ala Arg Asp Leu Leu Leu 
1               5                   10                  15      


Trp Leu Leu Leu Leu Ala Ala Trp Glu Val Gly Ser Gly Gln Leu His 
            20                  25                  30          


Tyr Ser Ile Pro Glu Glu Ala Lys His Gly Thr Phe Val Gly Arg Val 
        35                  40                  45              


Ala Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Pro Arg Leu Phe 
    50                  55                  60                  


Arg Val Ala Ser Lys Thr His Arg Asp Leu Leu Glu Val Asn Leu Gln 
65                  70                  75                  80  


Asn Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Gln Trp Ser Ala Glu Cys Ser Ile His Leu Glu Leu Ile Ala Asp Arg 
            100                 105                 110         


Pro Leu Gln Val Phe His Val Glu Val Lys Val Lys Asp Ile Asn Asp 
        115                 120                 125             


Asn Pro Pro Val Phe Arg Gly Arg Glu Gln Ile Ile Phe Ile Pro Glu 
    130                 135                 140                 


Ser Arg Leu Leu Asn Ser Arg Phe Pro Ile Glu Gly Ala Ala Asp Ala 
145                 150                 155                 160 


Asp Ile Gly Ala Asn Ala Leu Leu Thr Tyr Thr Leu Ser Pro Ser Asp 
                165                 170                 175     


Tyr Phe Ser Leu Asp Val Glu Ala Ser Asp Glu Leu Ser Lys Ser Leu 
            180                 185                 190         


Trp Leu Glu Leu Arg Lys Tyr Leu Asp Arg Glu Glu Thr Pro Glu Leu 
        195                 200                 205             


His Leu Leu Leu Thr Ala Thr Asp Gly Gly Lys Pro Glu Leu Gln Gly 
    210                 215                 220                 


Thr Val Glu Leu Leu Ile Thr Val Leu Asp Val Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Leu Phe Asp Gln Ala Val Tyr Arg Val His Leu Leu Glu Thr Thr Ala 
                245                 250                 255     


Asn Gly Thr Leu Val Thr Thr Leu Asn Ala Ser Asp Ala Asp Glu Gly 
            260                 265                 270         


Val Asn Gly Glu Val Val Phe Ser Phe Asp Ser Gly Ile Ser Arg Asp 
        275                 280                 285             


Ile Gln Glu Lys Phe Lys Val Asp Ser Ser Ser Gly Glu Ile Arg Leu 
    290                 295                 300                 


Ile Asp Lys Leu Asp Tyr Glu Glu Thr Lys Ser Tyr Glu Ile Gln Val 
305                 310                 315                 320 


Lys Ala Val Asp Lys Gly Ser Pro Pro Met Ser Asn His Cys Lys Val 
                325                 330                 335     


Leu Val Lys Val Leu Asp Val Asn Asp Asn Ala Pro Glu Leu Ala Val 
            340                 345                 350         


Thr Ser Leu Tyr Leu Pro Ile Arg Glu Asp Ala Pro Leu Ser Thr Val 
        355                 360                 365             


Ile Ala Leu Ile Thr Val Ser Asp Arg Asp Ser Gly Ala Asn Gly Gln 
    370                 375                 380                 


Val Thr Cys Ser Leu Met Pro His Val Pro Phe Lys Leu Val Ser Thr 
385                 390                 395                 400 


Phe Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu 
                405                 410                 415     


Ser Leu Ser Val Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser 
            420                 425                 430         


Pro Ser Leu Trp Ala Thr Ala Arg Val Ser Val Glu Val Ala Asp Val 
        435                 440                 445             


Asn Asp Asn Ala Pro Ala Phe Ala Gln Pro Glu Tyr Thr Val Phe Val 
    450                 455                 460                 


Lys Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Arg 
465                 470                 475                 480 


Asp Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu 
                485                 490                 495     


Arg Arg Val Gly Glu Arg Ala Leu Ser Asn Tyr Val Ser Val His Ala 
            500                 505                 510         


Glu Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu 
        515                 520                 525             


Glu Leu Leu Gln Phe Gln Val Ser Ala Arg Asp Ala Gly Val Pro Pro 
    530                 535                 540                 


Leu Gly Ser Asn Val Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp 
545                 550                 555                 560 


Asn Ala Pro Ala Leu Leu Ala Pro Arg Val Gly Gly Thr Ile Gly Ala 
                565                 570                 575     


Val Ser Glu Leu Val Pro Arg Leu Val Gly Ala Gly His Val Val Ala 
            580                 585                 590         


Lys Val Arg Ala Val Asp Ala Asp Ser Gly Tyr Asn Ala Trp Leu Ser 
        595                 600                 605             


Tyr Glu Leu Gln Pro Ala Ala Gly Gly Ala Arg Ile Pro Phe Arg Val 
    610                 615                 620                 


Gly Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Val Leu Asp Glu Ala 
625                 630                 635                 640 


Asp Leu Ser Arg Tyr Arg Leu Leu Val Leu Val Lys Asp His Gly Glu 
                645                 650                 655     


Pro Ala Leu Thr Ala Thr Ala Thr Val Leu Val Ser Leu Val Glu Ser 
            660                 665                 670         


Gly Gln Ala Pro Lys Ala Ser Ser Arg Ala Ser Val Gly Val Ala Gly 
        675                 680                 685             


Pro Glu Ala Ala Leu Val Asp Val Asn Val Tyr Leu Ile Ile Ala Ile 
    690                 695                 700                 


Cys Ala Val Ser Ser Leu Leu Val Leu Thr Leu Leu Leu Tyr Thr Ala 
705                 710                 715                 720 


Leu Arg Cys Ser Val Pro Pro Thr Glu Gly Ala Tyr Val Pro Gly Lys 
                725                 730                 735     


Pro Thr Leu Val Cys Ser Ser Ala Leu Gly Ser Trp Ser Asn Ser Gln 
            740                 745                 750         


Gln Arg Arg Gln Arg Val Cys Ser Ser Glu Gly Pro Pro Lys Thr Asp 
        755                 760                 765             


Leu Met Ala Phe Ser Pro Gly Leu Ser Pro Ser Leu Asn Thr Ser Glu 
    770                 775                 780                 


Arg Asn Glu Gln Pro Glu Ala Asn Leu Asp Leu Ser Gly Asn Pro Arg 
785                 790                 795                 800 


Gln Pro Asn Pro Asp Trp Arg Tyr Ser Ala Ser Leu Arg Ala Gly Met 
                805                 810                 815     


His Ser Ser Val His Leu Glu Glu Ala Gly Ile Leu Arg Ala Gly Pro 
            820                 825                 830         


Gly Gly Pro Asp Gln Gln Trp Pro Thr Val Ser Ser Ala Thr Pro Glu 
        835                 840                 845             


Pro Glu Ala Gly Glu Val Ser Pro Pro Val Gly Ala Gly Val Asn Ser 
    850                 855                 860                 


Asn Ser Trp Thr Phe Lys Tyr Gly Pro Gly Asn Pro Lys Gln Ser Gly 
865                 870                 875                 880 


Pro Gly Glu Leu Pro Asp Lys Phe Ile Ile Pro Gly Ser Pro Ala Ile 
                885                 890                 895     


Ile Ser Ile Arg Gln Glu Pro Thr Asn Ser Gln Ile Asp Lys Ser Asp 
            900                 905                 910         


Phe Ile Thr Phe Gly Lys Lys Glu Glu Thr Lys Lys Lys Lys Lys Lys 
        915                 920                 925             


Lys Lys Gly Asn Lys Thr Gln Glu Lys Lys Glu Lys Gly Asn Ser Thr 
    930                 935                 940                 


Thr Asp Asn Ser Asp Gln 
945                 950 

<210>  209
<211>  2571
<212>  DNA
<213>  Homo sapiens

<400>  209
atggtgtttt ctaggagagg gggcctggga gcccgggatc tgcttctttg gcttctgctc     60

ctcgcagcct gggaggtggg gagcggccag ctccactact cgatcccgga ggaagccaaa    120

cacggcacct tcgttggccg cgttgctcag gacctgggac tggagctggc ggagctggtg    180

cctcgcctgt tccgggtggc gtccaaaaca cacagggacc ttctggaggt aaatctgcag    240

aatggcattt tgtttgtgaa ttctcggatc gatcgcgagg agctgtgcca gtggagcgcg    300

gagtgcagca tccacctgga gttgatcgcc gacaggccgc tgcaggtttt ccatgtggag    360

gtgaaggtga aagacattaa cgataatcca cccgtcttca ggggcagaga acaaataata    420

tttattcctg aatctagact cctgaattcg cgttttccga tagaaggagc tgctgatgca    480

gacattggtg ctaacgctct tctaacgtac acgctcagcc cgagtgatta tttctctttg    540

gatgtagagg caagtgatga actgagtaaa tctctttggc ttgaattgag aaaatatttg    600

gatagagaag aaacaccaga acttcactta ttactgactg ccactgatgg gggcaaaccg    660

gagctgcaag gtacagttga gctgctgatc accgtcctcg acgttaatga taacgcccca    720

ctgtttgacc aggccgtata cagagtccac ttgttagaga ctacagcaaa tggaacatta    780

gtgaccacat taaatgcctc tgatgctgac gaaggtgtaa atggtgaagt cgtcttttcc    840

tttgacagtg gtatttctcg tgacattcaa gaaaaattca aagttgattc cagctcagga    900

gaaattaggt taattgataa actggattat gaagaaacaa aatcctacga aattcaagta    960

aaggcagttg ataaaggaag tcctccgatg tcaaatcact gtaaggtttt ggtgaaagtg   1020

ctggatgtaa atgataatgc tccagaactg gcggtcactt cattgtattt gcctatcaga   1080

gaggacgctc cactcagcac cgtcatcgcc ctcatcaccg tgtctgaccg tgactcaggt   1140

gccaacgggc aggtgacttg ctccttaatg ccccacgtcc ccttcaagct ggtgtccacc   1200

ttcaagaatt actactcgtt ggtgttggac agcgccctgg atcgcgagag cctgtcggtc   1260

tatgagctgg tggtgaccgc gcgggacggg ggctcgcctt cgctgtgggc cacggccagg   1320

gtgtccgtgg aggtggccga cgtgaatgac aacgcgcctg cgttcgcgca gcccgagtac   1380

acagtattcg tgaaggagaa caacccgccg ggctgccaca tcttcacggt gtctgcgcgg   1440

gacgcggacg cgcaggagaa cgcgctggtg tcctattcgc tggtggaacg gcgggtgggc   1500

gagcgcgcgc tgtcgaacta cgtgtcagtg cacgcggaga gcggcaaggt gtacgcactg   1560

cagcccctgg accacgagga gctggagctg ctgcagttcc aggtgagcgc gcgggatgcg   1620

ggcgtgccgc ctctgggcag caacgtgacg ctgcaggtgt tcgtgctgga cgagaacgac   1680

aacgcgccgg cgctgctggc gcctcgagtg ggtggcacta ttggtgcagt cagtgagctg   1740

gtgccgcgat tggtgggtgc gggtcatgtg gtggcgaagg tgcgcgcagt ggacgccgac   1800

tcgggctaca acgcgtggct gtcctatgaa ctgcagccgg cagcaggcgg cgcgcgcatc   1860

ccgttccgcg tggggctgta cacgggcgag atcagcacga ctcgtgtcct ggacgaggct   1920

gacttgtcgc gctaccgcct tctggtgcta gtgaaggatc acggtgagcc ggcgctgaca   1980

gccacggcca ctgtgcttgt atctctggtg gagagcggcc aggcgccaaa ggcgtcttcg   2040

cgggcgtcgg tgggtgtcgc gggcccagag gcggcgctgg tggatgtcaa cgtgtacctg   2100

atcatcgcca tctgcgcggt gtccagcctg ctggtgctca cactgctgct gtacacggcg   2160

ctgcggtgct cagtgccgcc cactgagggt gcgtatgtgc cgggcaagcc cactctggtg   2220

tgctccagcg cgttggggag ctggtcgaac tcacagcaga ggcggcagag ggtgtgctct   2280

agcgagggcc cacccaagac cgacctcatg gccttcagcc caggcctatc tccaagtctt   2340

aacacgtcag aaagaaatga acaaccagaa gcaaatttgg atctttctgg taatgtaagt   2400

ccaactttcg agttttggct ttaaatattt ttcatattta acttgtctaa tcatcttttc   2460

aaatatcact ttaaaaaatg tcttcaaggt gttcactaac gttgaaataa atcataccat   2520

tgaatgtaga tatcctatta atggcagttt tgtcttgaat ggaactagaa a            2571


<210>  210
<211>  807
<212>  PRT
<213>  Homo sapiens

<400>  210


Met Val Phe Ser Arg Arg Gly Gly Leu Gly Ala Arg Asp Leu Leu Leu 
1               5                   10                  15      


Trp Leu Leu Leu Leu Ala Ala Trp Glu Val Gly Ser Gly Gln Leu His 
            20                  25                  30          


Tyr Ser Ile Pro Glu Glu Ala Lys His Gly Thr Phe Val Gly Arg Val 
        35                  40                  45              


Ala Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Pro Arg Leu Phe 
    50                  55                  60                  


Arg Val Ala Ser Lys Thr His Arg Asp Leu Leu Glu Val Asn Leu Gln 
65                  70                  75                  80  


Asn Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Gln Trp Ser Ala Glu Cys Ser Ile His Leu Glu Leu Ile Ala Asp Arg 
            100                 105                 110         


Pro Leu Gln Val Phe His Val Glu Val Lys Val Lys Asp Ile Asn Asp 
        115                 120                 125             


Asn Pro Pro Val Phe Arg Gly Arg Glu Gln Ile Ile Phe Ile Pro Glu 
    130                 135                 140                 


Ser Arg Leu Leu Asn Ser Arg Phe Pro Ile Glu Gly Ala Ala Asp Ala 
145                 150                 155                 160 


Asp Ile Gly Ala Asn Ala Leu Leu Thr Tyr Thr Leu Ser Pro Ser Asp 
                165                 170                 175     


Tyr Phe Ser Leu Asp Val Glu Ala Ser Asp Glu Leu Ser Lys Ser Leu 
            180                 185                 190         


Trp Leu Glu Leu Arg Lys Tyr Leu Asp Arg Glu Glu Thr Pro Glu Leu 
        195                 200                 205             


His Leu Leu Leu Thr Ala Thr Asp Gly Gly Lys Pro Glu Leu Gln Gly 
    210                 215                 220                 


Thr Val Glu Leu Leu Ile Thr Val Leu Asp Val Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Leu Phe Asp Gln Ala Val Tyr Arg Val His Leu Leu Glu Thr Thr Ala 
                245                 250                 255     


Asn Gly Thr Leu Val Thr Thr Leu Asn Ala Ser Asp Ala Asp Glu Gly 
            260                 265                 270         


Val Asn Gly Glu Val Val Phe Ser Phe Asp Ser Gly Ile Ser Arg Asp 
        275                 280                 285             


Ile Gln Glu Lys Phe Lys Val Asp Ser Ser Ser Gly Glu Ile Arg Leu 
    290                 295                 300                 


Ile Asp Lys Leu Asp Tyr Glu Glu Thr Lys Ser Tyr Glu Ile Gln Val 
305                 310                 315                 320 


Lys Ala Val Asp Lys Gly Ser Pro Pro Met Ser Asn His Cys Lys Val 
                325                 330                 335     


Leu Val Lys Val Leu Asp Val Asn Asp Asn Ala Pro Glu Leu Ala Val 
            340                 345                 350         


Thr Ser Leu Tyr Leu Pro Ile Arg Glu Asp Ala Pro Leu Ser Thr Val 
        355                 360                 365             


Ile Ala Leu Ile Thr Val Ser Asp Arg Asp Ser Gly Ala Asn Gly Gln 
    370                 375                 380                 


Val Thr Cys Ser Leu Met Pro His Val Pro Phe Lys Leu Val Ser Thr 
385                 390                 395                 400 


Phe Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu 
                405                 410                 415     


Ser Leu Ser Val Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser 
            420                 425                 430         


Pro Ser Leu Trp Ala Thr Ala Arg Val Ser Val Glu Val Ala Asp Val 
        435                 440                 445             


Asn Asp Asn Ala Pro Ala Phe Ala Gln Pro Glu Tyr Thr Val Phe Val 
    450                 455                 460                 


Lys Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Arg 
465                 470                 475                 480 


Asp Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu 
                485                 490                 495     


Arg Arg Val Gly Glu Arg Ala Leu Ser Asn Tyr Val Ser Val His Ala 
            500                 505                 510         


Glu Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu 
        515                 520                 525             


Glu Leu Leu Gln Phe Gln Val Ser Ala Arg Asp Ala Gly Val Pro Pro 
    530                 535                 540                 


Leu Gly Ser Asn Val Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp 
545                 550                 555                 560 


Asn Ala Pro Ala Leu Leu Ala Pro Arg Val Gly Gly Thr Ile Gly Ala 
                565                 570                 575     


Val Ser Glu Leu Val Pro Arg Leu Val Gly Ala Gly His Val Val Ala 
            580                 585                 590         


Lys Val Arg Ala Val Asp Ala Asp Ser Gly Tyr Asn Ala Trp Leu Ser 
        595                 600                 605             


Tyr Glu Leu Gln Pro Ala Ala Gly Gly Ala Arg Ile Pro Phe Arg Val 
    610                 615                 620                 


Gly Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Val Leu Asp Glu Ala 
625                 630                 635                 640 


Asp Leu Ser Arg Tyr Arg Leu Leu Val Leu Val Lys Asp His Gly Glu 
                645                 650                 655     


Pro Ala Leu Thr Ala Thr Ala Thr Val Leu Val Ser Leu Val Glu Ser 
            660                 665                 670         


Gly Gln Ala Pro Lys Ala Ser Ser Arg Ala Ser Val Gly Val Ala Gly 
        675                 680                 685             


Pro Glu Ala Ala Leu Val Asp Val Asn Val Tyr Leu Ile Ile Ala Ile 
    690                 695                 700                 


Cys Ala Val Ser Ser Leu Leu Val Leu Thr Leu Leu Leu Tyr Thr Ala 
705                 710                 715                 720 


Leu Arg Cys Ser Val Pro Pro Thr Glu Gly Ala Tyr Val Pro Gly Lys 
                725                 730                 735     


Pro Thr Leu Val Cys Ser Ser Ala Leu Gly Ser Trp Ser Asn Ser Gln 
            740                 745                 750         


Gln Arg Arg Gln Arg Val Cys Ser Ser Glu Gly Pro Pro Lys Thr Asp 
        755                 760                 765             


Leu Met Ala Phe Ser Pro Gly Leu Ser Pro Ser Leu Asn Thr Ser Glu 
    770                 775                 780                 


Arg Asn Glu Gln Pro Glu Ala Asn Leu Asp Leu Ser Gly Asn Val Ser 
785                 790                 795                 800 


Pro Thr Phe Glu Phe Trp Leu 
                805         

<210>  211
<211>  4468
<212>  DNA
<213>  Homo sapiens

<400>  211
atggtgtttt ctaggagagg gggcctggga gcccgggatc tgcttctttg gcttctgctc     60

ctcgcagcct gggaggtggg gagcggccag ctccactact cgatcccgga ggaagccaaa    120

cacggcacct tcgttggccg cgttgctcag gacctgggac tggagctggc ggagctggtg    180

cctcgcctgt tccgggtggc gtccaaaaca cacagggacc ttctggaggt aaatctgcag    240

aatggcattt tgtttgtgaa ttctcggatc gatcgcgagg agctgtgcca gtggagcgcg    300

gagtgcagca tccacctgga gttgatcgcc gacaggccgc tgcaggtttt ccatgtggag    360

gtgaaggtga aagacattaa cgataatcca cccgtcttca ggggcagaga acaaataata    420

tttattcctg aatctagact cctgaattcg cgttttccga tagaaggagc tgctgatgca    480

gacattggtg ctaacgctct tctaacgtac acgctcagcc cgagtgatta tttctctttg    540

gatgtagagg caagtgatga actgagtaaa tctctttggc ttgaattgag aaaatatttg    600

gatagagaag aaacaccaga acttcactta ttactgactg ccactgatgg gggcaaaccg    660

gagctgcaag gtacagttga gctgctgatc accgtcctcg acgttaatga taacgcccca    720

ctgtttgacc aggccgtata cagagtccac ttgttagaga ctacagcaaa tggaacatta    780

gtgaccacat taaatgcctc tgatgctgac gaaggtgtaa atggtgaagt cgtcttttcc    840

tttgacagtg gtatttctcg tgacattcaa gaaaaattca aagttgattc cagctcagga    900

gaaattaggt taattgataa actggattat gaagaaacaa aatcctacga aattcaagta    960

aaggcagttg ataaaggaag tcctccgatg tcaaatcact gtaaggtttt ggtgaaagtg   1020

ctggatgtaa atgataatgc tccagaactg gcggtcactt cattgtattt gcctatcaga   1080

gaggacgctc cactcagcac cgtcatcgcc ctcatcaccg tgtctgaccg tgactcaggt   1140

gccaacgggc aggtgacttg ctccttaatg ccccacgtcc ccttcaagct ggtgtccacc   1200

ttcaagaatt actactcgtt ggtgttggac agcgccctgg atcgcgagag cctgtcggtc   1260

tatgagctgg tggtgaccgc gcgggacggg ggctcgcctt cgctgtgggc cacggccagg   1320

gtgtccgtgg aggtggccga cgtgaatgac aacgcgcctg cgttcgcgca gcccgagtac   1380

acagtattcg tgaaggagaa caacccgccg ggctgccaca tcttcacggt gtctgcgcgg   1440

gacgcggacg cgcaggagaa cgcgctggtg tcctattcgc tggtggaacg gcgggtgggc   1500

gagcgcgcgc tgtcgaacta cgtgtcagtg cacgcggaga gcggcaaggt gtacgcactg   1560

cagcccctgg accacgagga gctggagctg ctgcagttcc agccacgaca gcccaaccct   1620

gactggcgtt actctgcctc cctgagagca ggcatgcaca gctctgtgca cctagaggag   1680

gctggcattc tacgggctgg tccaggaggg cctgatcagc agtggccaac agtatccagt   1740

gcaacaccag aaccagaggc aggagaagtg tcccctccag tcggtgcggg tgtcaacagc   1800

aacagctgga cctttaaata cggaccaggc aaccccaaac aatccggtcc cggtgagttg   1860

cccgacaaat tcattatccc aggatctcct gcaatcatct ccatccggca ggagcctact   1920

aacagccaaa ttgacaaaag tgacttcata accttcggca aaaaggagga gaccaagaaa   1980

aagaagaaaa agaagaaggg taacaagacc caggagaaaa aagagaaagg gaacagcacg   2040

actgacaaca gtgaccagtg aggtcctcaa atggaaacaa gccacttagc cagtttttgt   2100

aataatggca aatctctccc atgtagcaat tccctgctcc tttttcctat ctacatgagc   2160

cctcttagag acctcagaaa tctgcagaaa gttccctgtg tctgtctaga acgcatttaa   2220

caggttttgt cgtaaaagct ttactaagtc tggtgttaac tctttctctc cactctggct   2280

tgttttcaga acctaaaaag cagacccaag tttcctttct cctccgccgc aaaggagagg   2340

cttcccagcc ccgccagtga gaggttggac tctctgccct gtgctccggg gatcctgtct   2400

tgatgacact tgcagggcag gctgaaaagt tttgagattg agcagcttgg gagtttgtgg   2460

ccactgggta tgtgtggcta ccgcgggtat gcgagtgcca gatattggct gagacgagcc   2520

agcttagact aattggtaca aggaaggcaa gaaaacaaag acaaataaac agcggaagtt   2580

atcagtatgg aggggaagtg taaacttaaa gggaccagac tttctaaatc ttacaactca   2640

agaggtggca gccaccctct aggagacaaa actaccccca ctgacaaggc tttaggagac   2700

cctaaagtct gttggctgtg acgtcattat acctaaaatc tgcatcatac ctgcaagcca   2760

acagttcagt gttttaacag agaaccaccc tgggaaacag aagcagatct gatgtgtttc   2820

ctatacatgt cctgtgctca ctttattaaa aattcttttg cacacaatgt ttatgaaaag   2880

gccagatcct tttccaatac ttatgcaaaa gcaaaagaaa accccgacac ctcacctttc   2940

gctgtttgtt gtttcataga tttatttaaa aaaagagaaa gtctatagct ataaatcttt   3000

aaagagaaat atgaatacaa ttcccctaaa ctctcctcaa aagagaattc agtctacagc   3060

catttaaatg atcattgctg ctacagaagt gctttaagag aattgcctga aacatctgta   3120

ttatatcggc cacctgccaa tcacagcttt actctttcag gtcactctgg ggctgcctct   3180

tgcatgtatt actaaataaa atgatctctc tttctctctc tctctctctt ttctaagaaa   3240

caattatgtg cactttgata cacaaccttc tctaaccaac tatatatcaa gacccaaaaa   3300

ttgaagaaaa atattgtttt ctcatacagt gagcagattt ttcaatctac taattctgtg   3360

acttgtcttg gtgtgctagc ctacaccttc tctttggttt agttttcctt ttctataaca   3420

ctctgaattg ctaatcttac taacacctat gatgttacct gaaatcaatc tcccatatgt   3480

atgctgtatg ctatgctaag actcctgaaa tatacttact ctgtgcttgt gtatgtgaat   3540

gttaatgcaa ctattaccta gagtgaactt taagctttat tgttgaatgt aattccatta   3600

tatttccttt tgtacacctg tgaaaaagtg gagtagtgtt tttttaacca ttgttaatca   3660

gcttttgtgt atgaaagaca cagtaaaatt tctttcttaa atcaagatac tggtgattca   3720

aggaatttta tttatggtcc agccaagagc catctcgtgc caagacttct gctggcaagg   3780

gaatggataa agctgttttg ttctagtaac aattttggaa tgaatactga caatattcca   3840

tgagggtgtg caagcacaaa ttttaccaat ctgacctctt tgaagttgca gaatgctttg   3900

aaattctaat ggtatctgaa atatcagctc atagaaagta acaaaatttg ctgtcacctt   3960

aaataagaca ttttaatttt gttataatgt acaatttaga agtttgatta attatattat   4020

ctatttaggc attaatataa aagaggtagg agtctgttat ttaaaaaaag cattaaattt   4080

aaaaaaaaac tgtcttgtct acttttagct tcattctccc atattttgaa gggtgtgtaa   4140

cttcagctct gcaggattgc atggggtaaa acttgttacc aacacatgtg aaccattgct   4200

acattgtagg ttgtgatcat tttgccccac tgaagcccat gtatctgacc ttacgtgcct   4260

tttgaactag gagaatcggg ctaatttatt aatgatgata attataatgt atctgtacag   4320

cactttttac atttgcgaag tgctttccaa tccatgttag ttactagtta ttacagctgt   4380

aaggataaaa cacgtcatgt ggattcattt tgaattggtg ctattggtat ttcctctgtt   4440

attgctaata aatgaaaatg gtggtatg                                      4468


<210>  212
<211>  686
<212>  PRT
<213>  Homo sapiens

<400>  212


Met Val Phe Ser Arg Arg Gly Gly Leu Gly Ala Arg Asp Leu Leu Leu 
1               5                   10                  15      


Trp Leu Leu Leu Leu Ala Ala Trp Glu Val Gly Ser Gly Gln Leu His 
            20                  25                  30          


Tyr Ser Ile Pro Glu Glu Ala Lys His Gly Thr Phe Val Gly Arg Val 
        35                  40                  45              


Ala Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Pro Arg Leu Phe 
    50                  55                  60                  


Arg Val Ala Ser Lys Thr His Arg Asp Leu Leu Glu Val Asn Leu Gln 
65                  70                  75                  80  


Asn Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Gln Trp Ser Ala Glu Cys Ser Ile His Leu Glu Leu Ile Ala Asp Arg 
            100                 105                 110         


Pro Leu Gln Val Phe His Val Glu Val Lys Val Lys Asp Ile Asn Asp 
        115                 120                 125             


Asn Pro Pro Val Phe Arg Gly Arg Glu Gln Ile Ile Phe Ile Pro Glu 
    130                 135                 140                 


Ser Arg Leu Leu Asn Ser Arg Phe Pro Ile Glu Gly Ala Ala Asp Ala 
145                 150                 155                 160 


Asp Ile Gly Ala Asn Ala Leu Leu Thr Tyr Thr Leu Ser Pro Ser Asp 
                165                 170                 175     


Tyr Phe Ser Leu Asp Val Glu Ala Ser Asp Glu Leu Ser Lys Ser Leu 
            180                 185                 190         


Trp Leu Glu Leu Arg Lys Tyr Leu Asp Arg Glu Glu Thr Pro Glu Leu 
        195                 200                 205             


His Leu Leu Leu Thr Ala Thr Asp Gly Gly Lys Pro Glu Leu Gln Gly 
    210                 215                 220                 


Thr Val Glu Leu Leu Ile Thr Val Leu Asp Val Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Leu Phe Asp Gln Ala Val Tyr Arg Val His Leu Leu Glu Thr Thr Ala 
                245                 250                 255     


Asn Gly Thr Leu Val Thr Thr Leu Asn Ala Ser Asp Ala Asp Glu Gly 
            260                 265                 270         


Val Asn Gly Glu Val Val Phe Ser Phe Asp Ser Gly Ile Ser Arg Asp 
        275                 280                 285             


Ile Gln Glu Lys Phe Lys Val Asp Ser Ser Ser Gly Glu Ile Arg Leu 
    290                 295                 300                 


Ile Asp Lys Leu Asp Tyr Glu Glu Thr Lys Ser Tyr Glu Ile Gln Val 
305                 310                 315                 320 


Lys Ala Val Asp Lys Gly Ser Pro Pro Met Ser Asn His Cys Lys Val 
                325                 330                 335     


Leu Val Lys Val Leu Asp Val Asn Asp Asn Ala Pro Glu Leu Ala Val 
            340                 345                 350         


Thr Ser Leu Tyr Leu Pro Ile Arg Glu Asp Ala Pro Leu Ser Thr Val 
        355                 360                 365             


Ile Ala Leu Ile Thr Val Ser Asp Arg Asp Ser Gly Ala Asn Gly Gln 
    370                 375                 380                 


Val Thr Cys Ser Leu Met Pro His Val Pro Phe Lys Leu Val Ser Thr 
385                 390                 395                 400 


Phe Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu 
                405                 410                 415     


Ser Leu Ser Val Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser 
            420                 425                 430         


Pro Ser Leu Trp Ala Thr Ala Arg Val Ser Val Glu Val Ala Asp Val 
        435                 440                 445             


Asn Asp Asn Ala Pro Ala Phe Ala Gln Pro Glu Tyr Thr Val Phe Val 
    450                 455                 460                 


Lys Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Arg 
465                 470                 475                 480 


Asp Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu 
                485                 490                 495     


Arg Arg Val Gly Glu Arg Ala Leu Ser Asn Tyr Val Ser Val His Ala 
            500                 505                 510         


Glu Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu 
        515                 520                 525             


Glu Leu Leu Gln Phe Gln Pro Arg Gln Pro Asn Pro Asp Trp Arg Tyr 
    530                 535                 540                 


Ser Ala Ser Leu Arg Ala Gly Met His Ser Ser Val His Leu Glu Glu 
545                 550                 555                 560 


Ala Gly Ile Leu Arg Ala Gly Pro Gly Gly Pro Asp Gln Gln Trp Pro 
                565                 570                 575     


Thr Val Ser Ser Ala Thr Pro Glu Pro Glu Ala Gly Glu Val Ser Pro 
            580                 585                 590         


Pro Val Gly Ala Gly Val Asn Ser Asn Ser Trp Thr Phe Lys Tyr Gly 
        595                 600                 605             


Pro Gly Asn Pro Lys Gln Ser Gly Pro Gly Glu Leu Pro Asp Lys Phe 
    610                 615                 620                 


Ile Ile Pro Gly Ser Pro Ala Ile Ile Ser Ile Arg Gln Glu Pro Thr 
625                 630                 635                 640 


Asn Ser Gln Ile Asp Lys Ser Asp Phe Ile Thr Phe Gly Lys Lys Glu 
                645                 650                 655     


Glu Thr Lys Lys Lys Lys Lys Lys Lys Lys Gly Asn Lys Thr Gln Glu 
            660                 665                 670         


Lys Lys Glu Lys Gly Asn Ser Thr Thr Asp Asn Ser Asp Gln 
        675                 680                 685     

<210>  213
<211>  5360
<212>  DNA
<213>  Homo sapiens

<400>  213
agaagcggag gaataagaga agcagcagga ctttaacaga gactagaata tttaaatttt     60

tgcaaaacat gctcttctaa tttgatcaaa acattgagga ttggtaatgg cgtcttctat    120

cagaaggggc cgaggggcct ggacacggct gctctcgctt ctgctcctcg cagcctggga    180

ggtggggagc ggccagctcc gctactccgt ccccgaggag gccaaacacg gcaccttcgt    240

gggccgcatc gcgcaggacc tggggctgga gctggaggag ctggtgccgc gcctgttccg    300

ggtggcgtcc aaaagacacg gggaccttct ggaggtaaat ctgcagaatg gcattttgtt    360

tgtgaattct cggatcgacc gggaggagct gtgcgggcgg agcgcggaat gtagcatcca    420

cgtggaggtg atcgtggaca ggccgctgca ggttttccat gtggaagtgg aggtgaagga    480

cattaacgac aacccgccaa tatttccaat gacagtaaag actatccggt ttcccgaatc    540

aaggctgctt gattctcggt ttcctctaga gggagcatct gatgcagata taggagtaaa    600

tgctcttctc tcctacaagc tcagctccag tgagtttttc ttcctagata tacaggcaaa    660

tgatgaacta agcgaatctt tgtctctcgt gctggggaaa tcgctggaca gagaggaaac    720

tgctgaggtt aatttgttac tggtggctac tgatgggggc aaacctgagc tcacgggcac    780

cgttcaaata cttattaagg tattagatgt aaatgacaat gaaccaactt ttgcccaatc    840

agtttacaaa gtaaaattgt tagagaatac ggcaaatggg accttagtgg ttaagttaaa    900

cgcttctgat gcagatgaag gaccgaacag cgagattgtg tattcactcg gtagtgatgt    960

gtcctccact atacagacta agtttaccat agatcccatc tcaggggaaa tcagaactaa   1020

gggaaaatta gattatgaag aagcaaagtc ctacgagatt caggtcactg caactgacaa   1080

aggaacccct tcaatgtcag gacattgtaa aatttcatta aaacttgtgg acatcaatga   1140

taacacacca gaagtctcaa taacgtctct ctcacttccc atctcagaga acgcttccct   1200

gggcactgtc attgctctca tcacggtgtc ggatcgcgac tctggtacga atggacatgt   1260

cacctgctcc ctgacgcccc acgtcccttt caagctggtg tccaccttca agaattacta   1320

ctcgttggtg ctggacagcg ccctggaccg cgagagcgtg tcagcctatg agctggtggt   1380

gaccgcacgg gacgggggct cgccttcact gtgggccacc accagcgtgt ccatcgaggt   1440

ggccgacgtg aacgacaacg cgccggcgtt cgcacagcct gagtacacag tattcgtgaa   1500

ggagaacaac ccgccgggct gccacatctt cacggtgtca gcgtgggatg cggacgcgca   1560

ggagaacgcg ctggtgtcct actcgctggt ggagcggcgg gtgggcgagc gcgcgttgtc   1620

gagctacgtt tcggtgcacg cggagagcgg caaggtgtac gcgctgcagc cgctggacca   1680

cgaggaagtg gagctgctgc agttccaggt gagcgcgcgg gatgcgggcg tgccgcctct   1740

gggcagcaac gtgacgctgc aggtgttcgt gctggacgag aacgacaacg cgccggcact   1800

gttggcgcct agggctggca ccgctgctgg cgcagtgagt gagctggtgc cgtggtcggt   1860

gggtgcaggg cacgtggtgg cgaaggtgcg cgcagtggac gctgactcag gctacaacgc   1920

gtggctttcg tacgagcttc agctgggtac tggcagcgct cgcatcccgt tccgcgtggg   1980

gctatacacg ggtgagatca gcacgacacg tgccctagac gaggctgact cccctcgaca   2040

ccgcctactc gtgctggtga aggaccacgg cgaaccagcg ttgacagcca cggccaccgt   2100

gttagtgtcg ttggtggaaa gtggccaggc acccaaggcc tcgtcgcggg cgtgggtggg   2160

cgccgcgggc tcagaggcta cgctggtgga tgtcaacgtg tacctgatca tcgccatctg   2220

cgcggtatcc agcctgttgg tgctcacggt gctgctgtac actgcgctgc ggtgctcggt   2280

gccacccacc gagggtgcgc gcgcgccagg aaagcccacg ctggtgtgct ccagcgccgt   2340

ggggagctgg tcttactcgc agcagaggcg gcagagggtg tgctctgggg aggacccccc   2400

caagacggac ctcatggcct tcagccctag cttatctcaa ggtccagact ccgcagaaga   2460

gaaacagctc tcagaatcag aatacgtagg aaagccacga cagcccaacc ctgactggcg   2520

ttactctgcc tccctgagag caggcatgca cagctctgtg cacctagagg aggctggcat   2580

tctacgggct ggtccaggag ggcctgatca gcagtggcca acagtatcca gtgcaacacc   2640

agaaccagag gcaggagaag tgtcccctcc agtcggtgcg ggtgtcaaca gcaacagctg   2700

gacctttaaa tacggaccag gcaaccccaa acaatccggt cccggtgagt tgcccgacaa   2760

attcattatc ccaggatctc ctgcaatcat ctccatccgg caggagccta ctaacagcca   2820

aattgacaaa agtgacttca taaccttcgg caaaaaggag gagaccaaga aaaagaagaa   2880

aaagaagaag ggtaacaaga cccaggagaa aaaagagaaa gggaacagca cgactgacaa   2940

cagtgaccag tgaggtcctc aaatggaaac aagccactta gccagttttt gtaataatgg   3000

caaatctctc ccatgtagca attccctgct cctttttcct atctacatga gccctcttag   3060

agacctcaga aatctgcaga aagttccctg tgtctgtcta gaacgcattt aacaggtttt   3120

gtcgtaaaag ctttactaag tctggtgtta actctttctc tccactctgg cttgttttca   3180

gaacctaaaa agcagaccca agtttccttt ctcctccgcc gcaaaggaga ggcttcccag   3240

ccccgccagt gagaggttgg actctctgcc ctgtgctccg gggatcctgt cttgatgaca   3300

cttgcagggc aggctgaaaa gttttgagat tgagcagctt gggagtttgt ggccactggg   3360

tatgtgtggc taccgcgggt atgcgagtgc cagatattgg ctgagacgag ccagcttaga   3420

ctaattggta caaggaaggc aagaaaacaa agacaaataa acagcggaag ttatcagtat   3480

ggaggggaag tgtaaactta aagggaccag actttctaaa tcttacaact caagaggtgg   3540

cagccaccct ctaggagaca aaactacccc cactgacaag gctttaggag accctaaagt   3600

ctgttggctg tgacgtcatt atacctaaaa tctgcatcat acctgcaagc caacagttca   3660

gtgttttaac agagaaccac cctgggaaac agaagcagat ctgatgtgtt tcctatacat   3720

gtcctgtgct cactttatta aaaattcttt tgcacacaat gtttatgaaa aggccagatc   3780

cttttccaat acttatgcaa aagcaaaaga aaaccccgac acctcacctt tcgctgtttg   3840

ttgtttcata gatttattta aaaaaagaga aagtctatag ctataaatct ttaaagagaa   3900

atatgaatac aattccccta aactctcctc aaaagagaat tcagtctaca gccatttaaa   3960

tgatcattgc tgctacagaa gtgctttaag agaattgcct gaaacatctg tattatatcg   4020

gccacctgcc aatcacagct ttactctttc aggtcactct ggggctgcct cttgcatgta   4080

ttactaaata aaatgatctc tctttctctc tctctctctc ttttctaaga aacaattatg   4140

tgcactttga tacacaacct tctctaacca actatatatc aagacccaaa aattgaagaa   4200

aaatattgtt ttctcataca gtgagcagat ttttcaatct actaattctg tgacttgtct   4260

tggtgtgcta gcctacacct tctctttggt ttagttttcc ttttctataa cactctgaat   4320

tgctaatctt actaacacct atgatgttac ctgaaatcaa tctcccatat gtatgctgta   4380

tgctatgcta agactcctga aatatactta ctctgtgctt gtgtatgtga atgttaatgc   4440

aactattacc tagagtgaac tttaagcttt attgttgaat gtaattccat tatatttcct   4500

tttgtacacc tgtgaaaaag tggagtagtg tttttttaac cattgttaat cagcttttgt   4560

gtatgaaaga cacagtaaaa tttctttctt aaatcaagat actggtgatt caaggaattt   4620

tatttatggt ccagccaaga gccatctcgt gccaagactt ctgctggcaa gggaatggat   4680

aaagctgttt tgttctagta acaattttgg aatgaatact gacaatattc catgagggtg   4740

tgcaagcaca aattttacca atctgacctc tttgaagttg cagaatgctt tgaaattcta   4800

atggtatctg aaatatcagc tcatagaaag taacaaaatt tgctgtcacc ttaaataaga   4860

cattttaatt ttgttataat gtacaattta gaagtttgat taattatatt atctatttag   4920

gcattaatat aaaagaggta ggagtctgtt atttaaaaaa agcattaaat ttaaaaaaaa   4980

actgtcttgt ctacttttag cttcattctc ccatattttg aagggtgtgt aacttcagct   5040

ctgcaggatt gcatggggta aaacttgtta ccaacacatg tgaaccattg ctacattgta   5100

ggttgtgatc attttgcccc actgaagccc atgtatctga ccttacgtgc cttttgaact   5160

aggagaatcg ggctaattta ttaatgatga taattataat gtatctgtac agcacttttt   5220

acatttgcga agtgctttcc aatccatgtt agttactagt tattacagct gtaaggataa   5280

aacacgtcat gtggattcat tttgaattgg tgctattggt atttcctctg ttattgctaa   5340

taaatgaaaa tggtggtatg                                               5360


<210>  214
<211>  948
<212>  PRT
<213>  Homo sapiens

<400>  214


Met Ala Ser Ser Ile Arg Arg Gly Arg Gly Ala Trp Thr Arg Leu Leu 
1               5                   10                  15      


Ser Leu Leu Leu Leu Ala Ala Trp Glu Val Gly Ser Gly Gln Leu Arg 
            20                  25                  30          


Tyr Ser Val Pro Glu Glu Ala Lys His Gly Thr Phe Val Gly Arg Ile 
        35                  40                  45              


Ala Gln Asp Leu Gly Leu Glu Leu Glu Glu Leu Val Pro Arg Leu Phe 
    50                  55                  60                  


Arg Val Ala Ser Lys Arg His Gly Asp Leu Leu Glu Val Asn Leu Gln 
65                  70                  75                  80  


Asn Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Gly Arg Ser Ala Glu Cys Ser Ile His Val Glu Val Ile Val Asp Arg 
            100                 105                 110         


Pro Leu Gln Val Phe His Val Glu Val Glu Val Lys Asp Ile Asn Asp 
        115                 120                 125             


Asn Pro Pro Ile Phe Pro Met Thr Val Lys Thr Ile Arg Phe Pro Glu 
    130                 135                 140                 


Ser Arg Leu Leu Asp Ser Arg Phe Pro Leu Glu Gly Ala Ser Asp Ala 
145                 150                 155                 160 


Asp Ile Gly Val Asn Ala Leu Leu Ser Tyr Lys Leu Ser Ser Ser Glu 
                165                 170                 175     


Phe Phe Phe Leu Asp Ile Gln Ala Asn Asp Glu Leu Ser Glu Ser Leu 
            180                 185                 190         


Ser Leu Val Leu Gly Lys Ser Leu Asp Arg Glu Glu Thr Ala Glu Val 
        195                 200                 205             


Asn Leu Leu Leu Val Ala Thr Asp Gly Gly Lys Pro Glu Leu Thr Gly 
    210                 215                 220                 


Thr Val Gln Ile Leu Ile Lys Val Leu Asp Val Asn Asp Asn Glu Pro 
225                 230                 235                 240 


Thr Phe Ala Gln Ser Val Tyr Lys Val Lys Leu Leu Glu Asn Thr Ala 
                245                 250                 255     


Asn Gly Thr Leu Val Val Lys Leu Asn Ala Ser Asp Ala Asp Glu Gly 
            260                 265                 270         


Pro Asn Ser Glu Ile Val Tyr Ser Leu Gly Ser Asp Val Ser Ser Thr 
        275                 280                 285             


Ile Gln Thr Lys Phe Thr Ile Asp Pro Ile Ser Gly Glu Ile Arg Thr 
    290                 295                 300                 


Lys Gly Lys Leu Asp Tyr Glu Glu Ala Lys Ser Tyr Glu Ile Gln Val 
305                 310                 315                 320 


Thr Ala Thr Asp Lys Gly Thr Pro Ser Met Ser Gly His Cys Lys Ile 
                325                 330                 335     


Ser Leu Lys Leu Val Asp Ile Asn Asp Asn Thr Pro Glu Val Ser Ile 
            340                 345                 350         


Thr Ser Leu Ser Leu Pro Ile Ser Glu Asn Ala Ser Leu Gly Thr Val 
        355                 360                 365             


Ile Ala Leu Ile Thr Val Ser Asp Arg Asp Ser Gly Thr Asn Gly His 
    370                 375                 380                 


Val Thr Cys Ser Leu Thr Pro His Val Pro Phe Lys Leu Val Ser Thr 
385                 390                 395                 400 


Phe Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu 
                405                 410                 415     


Ser Val Ser Ala Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser 
            420                 425                 430         


Pro Ser Leu Trp Ala Thr Thr Ser Val Ser Ile Glu Val Ala Asp Val 
        435                 440                 445             


Asn Asp Asn Ala Pro Ala Phe Ala Gln Pro Glu Tyr Thr Val Phe Val 
    450                 455                 460                 


Lys Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Trp 
465                 470                 475                 480 


Asp Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu 
                485                 490                 495     


Arg Arg Val Gly Glu Arg Ala Leu Ser Ser Tyr Val Ser Val His Ala 
            500                 505                 510         


Glu Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Val 
        515                 520                 525             


Glu Leu Leu Gln Phe Gln Val Ser Ala Arg Asp Ala Gly Val Pro Pro 
    530                 535                 540                 


Leu Gly Ser Asn Val Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp 
545                 550                 555                 560 


Asn Ala Pro Ala Leu Leu Ala Pro Arg Ala Gly Thr Ala Ala Gly Ala 
                565                 570                 575     


Val Ser Glu Leu Val Pro Trp Ser Val Gly Ala Gly His Val Val Ala 
            580                 585                 590         


Lys Val Arg Ala Val Asp Ala Asp Ser Gly Tyr Asn Ala Trp Leu Ser 
        595                 600                 605             


Tyr Glu Leu Gln Leu Gly Thr Gly Ser Ala Arg Ile Pro Phe Arg Val 
    610                 615                 620                 


Gly Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Ala Leu Asp Glu Ala 
625                 630                 635                 640 


Asp Ser Pro Arg His Arg Leu Leu Val Leu Val Lys Asp His Gly Glu 
                645                 650                 655     


Pro Ala Leu Thr Ala Thr Ala Thr Val Leu Val Ser Leu Val Glu Ser 
            660                 665                 670         


Gly Gln Ala Pro Lys Ala Ser Ser Arg Ala Trp Val Gly Ala Ala Gly 
        675                 680                 685             


Ser Glu Ala Thr Leu Val Asp Val Asn Val Tyr Leu Ile Ile Ala Ile 
    690                 695                 700                 


Cys Ala Val Ser Ser Leu Leu Val Leu Thr Val Leu Leu Tyr Thr Ala 
705                 710                 715                 720 


Leu Arg Cys Ser Val Pro Pro Thr Glu Gly Ala Arg Ala Pro Gly Lys 
                725                 730                 735     


Pro Thr Leu Val Cys Ser Ser Ala Val Gly Ser Trp Ser Tyr Ser Gln 
            740                 745                 750         


Gln Arg Arg Gln Arg Val Cys Ser Gly Glu Asp Pro Pro Lys Thr Asp 
        755                 760                 765             


Leu Met Ala Phe Ser Pro Ser Leu Ser Gln Gly Pro Asp Ser Ala Glu 
    770                 775                 780                 


Glu Lys Gln Leu Ser Glu Ser Glu Tyr Val Gly Lys Pro Arg Gln Pro 
785                 790                 795                 800 


Asn Pro Asp Trp Arg Tyr Ser Ala Ser Leu Arg Ala Gly Met His Ser 
                805                 810                 815     


Ser Val His Leu Glu Glu Ala Gly Ile Leu Arg Ala Gly Pro Gly Gly 
            820                 825                 830         


Pro Asp Gln Gln Trp Pro Thr Val Ser Ser Ala Thr Pro Glu Pro Glu 
        835                 840                 845             


Ala Gly Glu Val Ser Pro Pro Val Gly Ala Gly Val Asn Ser Asn Ser 
    850                 855                 860                 


Trp Thr Phe Lys Tyr Gly Pro Gly Asn Pro Lys Gln Ser Gly Pro Gly 
865                 870                 875                 880 


Glu Leu Pro Asp Lys Phe Ile Ile Pro Gly Ser Pro Ala Ile Ile Ser 
                885                 890                 895     


Ile Arg Gln Glu Pro Thr Asn Ser Gln Ile Asp Lys Ser Asp Phe Ile 
            900                 905                 910         


Thr Phe Gly Lys Lys Glu Glu Thr Lys Lys Lys Lys Lys Lys Lys Lys 
        915                 920                 925             


Gly Asn Lys Thr Gln Glu Lys Lys Glu Lys Gly Asn Ser Thr Thr Asp 
    930                 935                 940                 


Asn Ser Asp Gln 
945             

<210>  215
<211>  2619
<212>  DNA
<213>  Homo sapiens

<400>  215
agaagcggag gaataagaga agcagcagga ctttaacaga gactagaata tttaaatttt     60

tgcaaaacat gctcttctaa tttgatcaaa acattgagga ttggtaatgg cgtcttctat    120

cagaaggggc cgaggggcct ggacacggct gctctcgctt ctgctcctcg cagcctggga    180

ggtggggagc ggccagctcc gctactccgt ccccgaggag gccaaacacg gcaccttcgt    240

gggccgcatc gcgcaggacc tggggctgga gctggaggag ctggtgccgc gcctgttccg    300

ggtggcgtcc aaaagacacg gggaccttct ggaggtaaat ctgcagaatg gcattttgtt    360

tgtgaattct cggatcgacc gggaggagct gtgcgggcgg agcgcggaat gtagcatcca    420

cgtggaggtg atcgtggaca ggccgctgca ggttttccat gtggaagtgg aggtgaagga    480

cattaacgac aacccgccaa tatttccaat gacagtaaag actatccggt ttcccgaatc    540

aaggctgctt gattctcggt ttcctctaga gggagcatct gatgcagata taggagtaaa    600

tgctcttctc tcctacaagc tcagctccag tgagtttttc ttcctagata tacaggcaaa    660

tgatgaacta agcgaatctt tgtctctcgt gctggggaaa tcgctggaca gagaggaaac    720

tgctgaggtt aatttgttac tggtggctac tgatgggggc aaacctgagc tcacgggcac    780

cgttcaaata cttattaagg tattagatgt aaatgacaat gaaccaactt ttgcccaatc    840

agtttacaaa gtaaaattgt tagagaatac ggcaaatggg accttagtgg ttaagttaaa    900

cgcttctgat gcagatgaag gaccgaacag cgagattgtg tattcactcg gtagtgatgt    960

gtcctccact atacagacta agtttaccat agatcccatc tcaggggaaa tcagaactaa   1020

gggaaaatta gattatgaag aagcaaagtc ctacgagatt caggtcactg caactgacaa   1080

aggaacccct tcaatgtcag gacattgtaa aatttcatta aaacttgtgg acatcaatga   1140

taacacacca gaagtctcaa taacgtctct ctcacttccc atctcagaga acgcttccct   1200

gggcactgtc attgctctca tcacggtgtc ggatcgcgac tctggtacga atggacatgt   1260

cacctgctcc ctgacgcccc acgtcccttt caagctggtg tccaccttca agaattacta   1320

ctcgttggtg ctggacagcg ccctggaccg cgagagcgtg tcagcctatg agctggtggt   1380

gaccgcacgg gacgggggct cgccttcact gtgggccacc accagcgtgt ccatcgaggt   1440

ggccgacgtg aacgacaacg cgccggcgtt cgcacagcct gagtacacag tattcgtgaa   1500

ggagaacaac ccgccgggct gccacatctt cacggtgtca gcgtgggatg cggacgcgca   1560

ggagaacgcg ctggtgtcct actcgctggt ggagcggcgg gtgggcgagc gcgcgttgtc   1620

gagctacgtt tcggtgcacg cggagagcgg caaggtgtac gcgctgcagc cgctggacca   1680

cgaggaagtg gagctgctgc agttccaggt gagcgcgcgg gatgcgggcg tgccgcctct   1740

gggcagcaac gtgacgctgc aggtgttcgt gctggacgag aacgacaacg cgccggcact   1800

gttggcgcct agggctggca ccgctgctgg cgcagtgagt gagctggtgc cgtggtcggt   1860

gggtgcaggg cacgtggtgg cgaaggtgcg cgcagtggac gctgactcag gctacaacgc   1920

gtggctttcg tacgagcttc agctgggtac tggcagcgct cgcatcccgt tccgcgtggg   1980

gctatacacg ggtgagatca gcacgacacg tgccctagac gaggctgact cccctcgaca   2040

ccgcctactc gtgctggtga aggaccacgg cgaaccagcg ttgacagcca cggccaccgt   2100

gttagtgtcg ttggtggaaa gtggccaggc acccaaggcc tcgtcgcggg cgtgggtggg   2160

cgccgcgggc tcagaggcta cgctggtgga tgtcaacgtg tacctgatca tcgccatctg   2220

cgcggtatcc agcctgttgg tgctcacggt gctgctgtac actgcgctgc ggtgctcggt   2280

gccacccacc gagggtgcgc gcgcgccagg aaagcccacg ctggtgtgct ccagcgccgt   2340

ggggagctgg tcttactcgc agcagaggcg gcagagggtg tgctctgggg aggacccccc   2400

caagacggac ctcatggcct tcagccctag cttatctcaa ggtccagact ccgcagaaga   2460

gaaacagctc tcagaatcag aatacgtagg aaaggtgagt cttttacttt ttcttgccaa   2520

ttctaaaatt gttcttttta aaaaattcta tatgatttct actagttatt tagattcata   2580

gttcttcatt tattttatat catcctaccg tgcgatttt                          2619


<210>  216
<211>  824
<212>  PRT
<213>  Homo sapiens

<400>  216


Met Ala Ser Ser Ile Arg Arg Gly Arg Gly Ala Trp Thr Arg Leu Leu 
1               5                   10                  15      


Ser Leu Leu Leu Leu Ala Ala Trp Glu Val Gly Ser Gly Gln Leu Arg 
            20                  25                  30          


Tyr Ser Val Pro Glu Glu Ala Lys His Gly Thr Phe Val Gly Arg Ile 
        35                  40                  45              


Ala Gln Asp Leu Gly Leu Glu Leu Glu Glu Leu Val Pro Arg Leu Phe 
    50                  55                  60                  


Arg Val Ala Ser Lys Arg His Gly Asp Leu Leu Glu Val Asn Leu Gln 
65                  70                  75                  80  


Asn Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Gly Arg Ser Ala Glu Cys Ser Ile His Val Glu Val Ile Val Asp Arg 
            100                 105                 110         


Pro Leu Gln Val Phe His Val Glu Val Glu Val Lys Asp Ile Asn Asp 
        115                 120                 125             


Asn Pro Pro Ile Phe Pro Met Thr Val Lys Thr Ile Arg Phe Pro Glu 
    130                 135                 140                 


Ser Arg Leu Leu Asp Ser Arg Phe Pro Leu Glu Gly Ala Ser Asp Ala 
145                 150                 155                 160 


Asp Ile Gly Val Asn Ala Leu Leu Ser Tyr Lys Leu Ser Ser Ser Glu 
                165                 170                 175     


Phe Phe Phe Leu Asp Ile Gln Ala Asn Asp Glu Leu Ser Glu Ser Leu 
            180                 185                 190         


Ser Leu Val Leu Gly Lys Ser Leu Asp Arg Glu Glu Thr Ala Glu Val 
        195                 200                 205             


Asn Leu Leu Leu Val Ala Thr Asp Gly Gly Lys Pro Glu Leu Thr Gly 
    210                 215                 220                 


Thr Val Gln Ile Leu Ile Lys Val Leu Asp Val Asn Asp Asn Glu Pro 
225                 230                 235                 240 


Thr Phe Ala Gln Ser Val Tyr Lys Val Lys Leu Leu Glu Asn Thr Ala 
                245                 250                 255     


Asn Gly Thr Leu Val Val Lys Leu Asn Ala Ser Asp Ala Asp Glu Gly 
            260                 265                 270         


Pro Asn Ser Glu Ile Val Tyr Ser Leu Gly Ser Asp Val Ser Ser Thr 
        275                 280                 285             


Ile Gln Thr Lys Phe Thr Ile Asp Pro Ile Ser Gly Glu Ile Arg Thr 
    290                 295                 300                 


Lys Gly Lys Leu Asp Tyr Glu Glu Ala Lys Ser Tyr Glu Ile Gln Val 
305                 310                 315                 320 


Thr Ala Thr Asp Lys Gly Thr Pro Ser Met Ser Gly His Cys Lys Ile 
                325                 330                 335     


Ser Leu Lys Leu Val Asp Ile Asn Asp Asn Thr Pro Glu Val Ser Ile 
            340                 345                 350         


Thr Ser Leu Ser Leu Pro Ile Ser Glu Asn Ala Ser Leu Gly Thr Val 
        355                 360                 365             


Ile Ala Leu Ile Thr Val Ser Asp Arg Asp Ser Gly Thr Asn Gly His 
    370                 375                 380                 


Val Thr Cys Ser Leu Thr Pro His Val Pro Phe Lys Leu Val Ser Thr 
385                 390                 395                 400 


Phe Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu 
                405                 410                 415     


Ser Val Ser Ala Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser 
            420                 425                 430         


Pro Ser Leu Trp Ala Thr Thr Ser Val Ser Ile Glu Val Ala Asp Val 
        435                 440                 445             


Asn Asp Asn Ala Pro Ala Phe Ala Gln Pro Glu Tyr Thr Val Phe Val 
    450                 455                 460                 


Lys Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Trp 
465                 470                 475                 480 


Asp Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu 
                485                 490                 495     


Arg Arg Val Gly Glu Arg Ala Leu Ser Ser Tyr Val Ser Val His Ala 
            500                 505                 510         


Glu Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Val 
        515                 520                 525             


Glu Leu Leu Gln Phe Gln Val Ser Ala Arg Asp Ala Gly Val Pro Pro 
    530                 535                 540                 


Leu Gly Ser Asn Val Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp 
545                 550                 555                 560 


Asn Ala Pro Ala Leu Leu Ala Pro Arg Ala Gly Thr Ala Ala Gly Ala 
                565                 570                 575     


Val Ser Glu Leu Val Pro Trp Ser Val Gly Ala Gly His Val Val Ala 
            580                 585                 590         


Lys Val Arg Ala Val Asp Ala Asp Ser Gly Tyr Asn Ala Trp Leu Ser 
        595                 600                 605             


Tyr Glu Leu Gln Leu Gly Thr Gly Ser Ala Arg Ile Pro Phe Arg Val 
    610                 615                 620                 


Gly Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Ala Leu Asp Glu Ala 
625                 630                 635                 640 


Asp Ser Pro Arg His Arg Leu Leu Val Leu Val Lys Asp His Gly Glu 
                645                 650                 655     


Pro Ala Leu Thr Ala Thr Ala Thr Val Leu Val Ser Leu Val Glu Ser 
            660                 665                 670         


Gly Gln Ala Pro Lys Ala Ser Ser Arg Ala Trp Val Gly Ala Ala Gly 
        675                 680                 685             


Ser Glu Ala Thr Leu Val Asp Val Asn Val Tyr Leu Ile Ile Ala Ile 
    690                 695                 700                 


Cys Ala Val Ser Ser Leu Leu Val Leu Thr Val Leu Leu Tyr Thr Ala 
705                 710                 715                 720 


Leu Arg Cys Ser Val Pro Pro Thr Glu Gly Ala Arg Ala Pro Gly Lys 
                725                 730                 735     


Pro Thr Leu Val Cys Ser Ser Ala Val Gly Ser Trp Ser Tyr Ser Gln 
            740                 745                 750         


Gln Arg Arg Gln Arg Val Cys Ser Gly Glu Asp Pro Pro Lys Thr Asp 
        755                 760                 765             


Leu Met Ala Phe Ser Pro Ser Leu Ser Gln Gly Pro Asp Ser Ala Glu 
    770                 775                 780                 


Glu Lys Gln Leu Ser Glu Ser Glu Tyr Val Gly Lys Val Ser Leu Leu 
785                 790                 795                 800 


Leu Phe Leu Ala Asn Ser Lys Ile Val Leu Phe Lys Lys Phe Tyr Met 
                805                 810                 815     


Ile Ser Thr Ser Tyr Leu Asp Ser 
            820                 

<210>  217
<211>  5260
<212>  DNA
<213>  Homo sapiens

<400>  217
atgttgttct cctggcgaga agatcctgga gcccagtgcc tgctgctttc tcttctgctc     60

ctcgcagcct cggaggtggg gagcggccag ctccactact ccgtctctga ggaggccaag    120

catggcacct tcgtgggccg catcgcgcag gacctggggc tggagctggc ggagctggtg    180

ccgcgcctgt tccgggtggc gtccaaaaga cacggggacc ttctggaggt aaatctgcag    240

aatggcattt tgtttgtgaa ttctcggata gaccgcgagg aactgtgcgg gcggagcgcg    300

gagtgcagca tccacctgga ggtgatcgtg gacaggccgc tgcaggtttt ccatgtggag    360

gtggaagtga aggacattaa tgacaacgcg ccagtttttc caatggctgt aaagaatctg    420

tttatttccg aatcccgaca gcctggctct cggttttcgc tagagggcgc atcagatgca    480

gatatcggaa caaattcgtt gttgacttac agtcttgatt ccactgaata ttttaccttg    540

gacgttaaaa gaaatgatga ggaaattaaa tcccttggac tcgtgttgaa aaaaaattta    600

aatcgagagg acactcctaa gcattattta ctaataacag caattgatgg tgggaaacca    660

gagctcactg gcacgactca actaaagatc actgttttag atgtaaacga caacgcccca    720

gcgtttgaga ggacgatcta taaagtcaga ttactcgaaa atgcaccaaa tggtacccta    780

gtggtgaccg ttaacgccac cgatttggat gaaggagtaa ataaggatat cgcgtattct    840

ttcaatacgg acatgtcagc agatattctg tcaaaattcc atttagatcc agtcaatgga    900

caaatcagtg taaagggtaa catagatttc gaggaaagta agtcatatga aatccaggta    960

gaagccacgg ataaaggaaa tcccccaatg tcagatcact gcacagttct actcgaaatt   1020

gtggacatca atgataatgt acctgagtta gttattcaat cactatcttt acctgtatta   1080

gaagactctc cacttagcac agtcatcgct ctgatcagcg tgtccgaccg cgactcagga   1140

gtcaatggac aggtcacctg ctcgctgacg ccccacgtcc ccttcaagct ggtgtccacc   1200

ttcaagaatt actactcatt ggtgctggac agccctctgg accgcgagag cgtgtcggcc   1260

tatgagctgg tggtgactgc tcgggacggg ggctcgcctt cactgtgggc cacggccagc   1320

gtgtccgtgg aggtggccga cgtgaacgac aatgcgccgg cattctcgca gtccgagtac   1380

acggtgttcg tgaaggagaa caacccgccg ggctgccaca tcttcacggt gtctgcgcgg   1440

gacgcggacg cgcaggagaa cgccctggtg tcctactcgc tggtggaacg gcgggtgggg   1500

gagcgcgcgc tgtcgagcta cgtgtcggta cacgcggaga gcggcaaggt gtacgcgctg   1560

cagccgctgg accacgagga gctagagctg ctgcagttcc aggtgagtgc gcgcgatgcg   1620

ggcgtgccgc ctctgggcag caacgtgacg ctgcaggtgt tcgtgctgga cgagaacgac   1680

aacgcgccgg cactgctgat gcctcgggtg ggtggcatcg gtggcgcagt gagcgagctg   1740

gtgccgcggt cagtgggtgc gggccacgtg gtagcgaagg tgcgcgcagt ggatgcagac   1800

tcaggctaca acgcgtggct ttcgtatgag ctgcagcctg ggaccggcgg tgcgcgcatc   1860

ccgtttcgcg tggggctgta cacgggagag atcagcacga cccgtgccct ggacgaggtg   1920

gacgccccgc gccatcgcct actggtgctg gtgaaggacc acggtgaacc ctcattgacc   1980

gccacggcca ctgtgctggt gtcgctggtg gagagtggcc aggcacccaa ggcctcgtcc   2040

caggcgtccg ctggcgccac gggcccggaa gctgcactgg tggatgtcaa cgtgtacttg   2100

atcgtcgcca tctgcgcggt gtccagtctg ttggtgctca cactgctgct atatactgct   2160

ctgcggtgct ccgcgccgcc aaccgaaggc gactgtgggc cgggcaagcc cacgctggtg   2220

tgctccagcg cggtggggag ctggtcatac tcgcagcaga ggcagcagag ggtgtgctct   2280

ggagaggggt tgcccaagac cgacctcatg gcttttagcc ctagccttcc tccttgtcca   2340

attagccggg atagagagga gaaacaggat gtggacgttg atctctcagc caaaccacga   2400

cagcccaacc ctgactggcg ttactctgcc tccctgagag caggcatgca cagctctgtg   2460

cacctagagg aggctggcat tctacgggct ggtccaggag ggcctgatca gcagtggcca   2520

acagtatcca gtgcaacacc agaaccagag gcaggagaag tgtcccctcc agtcggtgcg   2580

ggtgtcaaca gcaacagctg gacctttaaa tacggaccag gcaaccccaa acaatccggt   2640

cccggtgagt tgcccgacaa attcattatc ccaggatctc ctgcaatcat ctccatccgg   2700

caggagccta ctaacagcca aattgacaaa agtgacttca taaccttcgg caaaaaggag   2760

gagaccaaga aaaagaagaa aaagaagaag ggtaacaaga cccaggagaa aaaagagaaa   2820

gggaacagca cgactgacaa cagtgaccag tgaggtcctc aaatggaaac aagccactta   2880

gccagttttt gtaataatgg caaatctctc ccatgtagca attccctgct cctttttcct   2940

atctacatga gccctcttag agacctcaga aatctgcaga aagttccctg tgtctgtcta   3000

gaacgcattt aacaggtttt gtcgtaaaag ctttactaag tctggtgtta actctttctc   3060

tccactctgg cttgttttca gaacctaaaa agcagaccca agtttccttt ctcctccgcc   3120

gcaaaggaga ggcttcccag ccccgccagt gagaggttgg actctctgcc ctgtgctccg   3180

gggatcctgt cttgatgaca cttgcagggc aggctgaaaa gttttgagat tgagcagctt   3240

gggagtttgt ggccactggg tatgtgtggc taccgcgggt atgcgagtgc cagatattgg   3300

ctgagacgag ccagcttaga ctaattggta caaggaaggc aagaaaacaa agacaaataa   3360

acagcggaag ttatcagtat ggaggggaag tgtaaactta aagggaccag actttctaaa   3420

tcttacaact caagaggtgg cagccaccct ctaggagaca aaactacccc cactgacaag   3480

gctttaggag accctaaagt ctgttggctg tgacgtcatt atacctaaaa tctgcatcat   3540

acctgcaagc caacagttca gtgttttaac agagaaccac cctgggaaac agaagcagat   3600

ctgatgtgtt tcctatacat gtcctgtgct cactttatta aaaattcttt tgcacacaat   3660

gtttatgaaa aggccagatc cttttccaat acttatgcaa aagcaaaaga aaaccccgac   3720

acctcacctt tcgctgtttg ttgtttcata gatttattta aaaaaagaga aagtctatag   3780

ctataaatct ttaaagagaa atatgaatac aattccccta aactctcctc aaaagagaat   3840

tcagtctaca gccatttaaa tgatcattgc tgctacagaa gtgctttaag agaattgcct   3900

gaaacatctg tattatatcg gccacctgcc aatcacagct ttactctttc aggtcactct   3960

ggggctgcct cttgcatgta ttactaaata aaatgatctc tctttctctc tctctctctc   4020

ttttctaaga aacaattatg tgcactttga tacacaacct tctctaacca actatatatc   4080

aagacccaaa aattgaagaa aaatattgtt ttctcataca gtgagcagat ttttcaatct   4140

actaattctg tgacttgtct tggtgtgcta gcctacacct tctctttggt ttagttttcc   4200

ttttctataa cactctgaat tgctaatctt actaacacct atgatgttac ctgaaatcaa   4260

tctcccatat gtatgctgta tgctatgcta agactcctga aatatactta ctctgtgctt   4320

gtgtatgtga atgttaatgc aactattacc tagagtgaac tttaagcttt attgttgaat   4380

gtaattccat tatatttcct tttgtacacc tgtgaaaaag tggagtagtg tttttttaac   4440

cattgttaat cagcttttgt gtatgaaaga cacagtaaaa tttctttctt aaatcaagat   4500

actggtgatt caaggaattt tatttatggt ccagccaaga gccatctcgt gccaagactt   4560

ctgctggcaa gggaatggat aaagctgttt tgttctagta acaattttgg aatgaatact   4620

gacaatattc catgagggtg tgcaagcaca aattttacca atctgacctc tttgaagttg   4680

cagaatgctt tgaaattcta atggtatctg aaatatcagc tcatagaaag taacaaaatt   4740

tgctgtcacc ttaaataaga cattttaatt ttgttataat gtacaattta gaagtttgat   4800

taattatatt atctatttag gcattaatat aaaagaggta ggagtctgtt atttaaaaaa   4860

agcattaaat ttaaaaaaaa actgtcttgt ctacttttag cttcattctc ccatattttg   4920

aagggtgtgt aacttcagct ctgcaggatt gcatggggta aaacttgtta ccaacacatg   4980

tgaaccattg ctacattgta ggttgtgatc attttgcccc actgaagccc atgtatctga   5040

ccttacgtgc cttttgaact aggagaatcg ggctaattta ttaatgatga taattataat   5100

gtatctgtac agcacttttt acatttgcga agtgctttcc aatccatgtt agttactagt   5160

tattacagct gtaaggataa aacacgtcat gtggattcat tttgaattgg tgctattggt   5220

atttcctctg ttattgctaa taaatgaaaa tggtggtatg                         5260


<210>  218
<211>  950
<212>  PRT
<213>  Homo sapiens

<400>  218


Met Leu Phe Ser Trp Arg Glu Asp Pro Gly Ala Gln Cys Leu Leu Leu 
1               5                   10                  15      


Ser Leu Leu Leu Leu Ala Ala Ser Glu Val Gly Ser Gly Gln Leu His 
            20                  25                  30          


Tyr Ser Val Ser Glu Glu Ala Lys His Gly Thr Phe Val Gly Arg Ile 
        35                  40                  45              


Ala Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Pro Arg Leu Phe 
    50                  55                  60                  


Arg Val Ala Ser Lys Arg His Gly Asp Leu Leu Glu Val Asn Leu Gln 
65                  70                  75                  80  


Asn Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Gly Arg Ser Ala Glu Cys Ser Ile His Leu Glu Val Ile Val Asp Arg 
            100                 105                 110         


Pro Leu Gln Val Phe His Val Glu Val Glu Val Lys Asp Ile Asn Asp 
        115                 120                 125             


Asn Ala Pro Val Phe Pro Met Ala Val Lys Asn Leu Phe Ile Ser Glu 
    130                 135                 140                 


Ser Arg Gln Pro Gly Ser Arg Phe Ser Leu Glu Gly Ala Ser Asp Ala 
145                 150                 155                 160 


Asp Ile Gly Thr Asn Ser Leu Leu Thr Tyr Ser Leu Asp Ser Thr Glu 
                165                 170                 175     


Tyr Phe Thr Leu Asp Val Lys Arg Asn Asp Glu Glu Ile Lys Ser Leu 
            180                 185                 190         


Gly Leu Val Leu Lys Lys Asn Leu Asn Arg Glu Asp Thr Pro Lys His 
        195                 200                 205             


Tyr Leu Leu Ile Thr Ala Ile Asp Gly Gly Lys Pro Glu Leu Thr Gly 
    210                 215                 220                 


Thr Thr Gln Leu Lys Ile Thr Val Leu Asp Val Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Ala Phe Glu Arg Thr Ile Tyr Lys Val Arg Leu Leu Glu Asn Ala Pro 
                245                 250                 255     


Asn Gly Thr Leu Val Val Thr Val Asn Ala Thr Asp Leu Asp Glu Gly 
            260                 265                 270         


Val Asn Lys Asp Ile Ala Tyr Ser Phe Asn Thr Asp Met Ser Ala Asp 
        275                 280                 285             


Ile Leu Ser Lys Phe His Leu Asp Pro Val Asn Gly Gln Ile Ser Val 
    290                 295                 300                 


Lys Gly Asn Ile Asp Phe Glu Glu Ser Lys Ser Tyr Glu Ile Gln Val 
305                 310                 315                 320 


Glu Ala Thr Asp Lys Gly Asn Pro Pro Met Ser Asp His Cys Thr Val 
                325                 330                 335     


Leu Leu Glu Ile Val Asp Ile Asn Asp Asn Val Pro Glu Leu Val Ile 
            340                 345                 350         


Gln Ser Leu Ser Leu Pro Val Leu Glu Asp Ser Pro Leu Ser Thr Val 
        355                 360                 365             


Ile Ala Leu Ile Ser Val Ser Asp Arg Asp Ser Gly Val Asn Gly Gln 
    370                 375                 380                 


Val Thr Cys Ser Leu Thr Pro His Val Pro Phe Lys Leu Val Ser Thr 
385                 390                 395                 400 


Phe Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Pro Leu Asp Arg Glu 
                405                 410                 415     


Ser Val Ser Ala Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser 
            420                 425                 430         


Pro Ser Leu Trp Ala Thr Ala Ser Val Ser Val Glu Val Ala Asp Val 
        435                 440                 445             


Asn Asp Asn Ala Pro Ala Phe Ser Gln Ser Glu Tyr Thr Val Phe Val 
    450                 455                 460                 


Lys Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Arg 
465                 470                 475                 480 


Asp Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu 
                485                 490                 495     


Arg Arg Val Gly Glu Arg Ala Leu Ser Ser Tyr Val Ser Val His Ala 
            500                 505                 510         


Glu Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu 
        515                 520                 525             


Glu Leu Leu Gln Phe Gln Val Ser Ala Arg Asp Ala Gly Val Pro Pro 
    530                 535                 540                 


Leu Gly Ser Asn Val Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp 
545                 550                 555                 560 


Asn Ala Pro Ala Leu Leu Met Pro Arg Val Gly Gly Ile Gly Gly Ala 
                565                 570                 575     


Val Ser Glu Leu Val Pro Arg Ser Val Gly Ala Gly His Val Val Ala 
            580                 585                 590         


Lys Val Arg Ala Val Asp Ala Asp Ser Gly Tyr Asn Ala Trp Leu Ser 
        595                 600                 605             


Tyr Glu Leu Gln Pro Gly Thr Gly Gly Ala Arg Ile Pro Phe Arg Val 
    610                 615                 620                 


Gly Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Ala Leu Asp Glu Val 
625                 630                 635                 640 


Asp Ala Pro Arg His Arg Leu Leu Val Leu Val Lys Asp His Gly Glu 
                645                 650                 655     


Pro Ser Leu Thr Ala Thr Ala Thr Val Leu Val Ser Leu Val Glu Ser 
            660                 665                 670         


Gly Gln Ala Pro Lys Ala Ser Ser Gln Ala Ser Ala Gly Ala Thr Gly 
        675                 680                 685             


Pro Glu Ala Ala Leu Val Asp Val Asn Val Tyr Leu Ile Val Ala Ile 
    690                 695                 700                 


Cys Ala Val Ser Ser Leu Leu Val Leu Thr Leu Leu Leu Tyr Thr Ala 
705                 710                 715                 720 


Leu Arg Cys Ser Ala Pro Pro Thr Glu Gly Asp Cys Gly Pro Gly Lys 
                725                 730                 735     


Pro Thr Leu Val Cys Ser Ser Ala Val Gly Ser Trp Ser Tyr Ser Gln 
            740                 745                 750         


Gln Arg Gln Gln Arg Val Cys Ser Gly Glu Gly Leu Pro Lys Thr Asp 
        755                 760                 765             


Leu Met Ala Phe Ser Pro Ser Leu Pro Pro Cys Pro Ile Ser Arg Asp 
    770                 775                 780                 


Arg Glu Glu Lys Gln Asp Val Asp Val Asp Leu Ser Ala Lys Pro Arg 
785                 790                 795                 800 


Gln Pro Asn Pro Asp Trp Arg Tyr Ser Ala Ser Leu Arg Ala Gly Met 
                805                 810                 815     


His Ser Ser Val His Leu Glu Glu Ala Gly Ile Leu Arg Ala Gly Pro 
            820                 825                 830         


Gly Gly Pro Asp Gln Gln Trp Pro Thr Val Ser Ser Ala Thr Pro Glu 
        835                 840                 845             


Pro Glu Ala Gly Glu Val Ser Pro Pro Val Gly Ala Gly Val Asn Ser 
    850                 855                 860                 


Asn Ser Trp Thr Phe Lys Tyr Gly Pro Gly Asn Pro Lys Gln Ser Gly 
865                 870                 875                 880 


Pro Gly Glu Leu Pro Asp Lys Phe Ile Ile Pro Gly Ser Pro Ala Ile 
                885                 890                 895     


Ile Ser Ile Arg Gln Glu Pro Thr Asn Ser Gln Ile Asp Lys Ser Asp 
            900                 905                 910         


Phe Ile Thr Phe Gly Lys Lys Glu Glu Thr Lys Lys Lys Lys Lys Lys 
        915                 920                 925             


Lys Lys Gly Asn Lys Thr Gln Glu Lys Lys Glu Lys Gly Asn Ser Thr 
    930                 935                 940                 


Thr Asp Asn Ser Asp Gln 
945                 950 

<210>  219
<211>  2475
<212>  DNA
<213>  Homo sapiens

<400>  219
atgttgttct cctggcgaga agatcctgga gcccagtgcc tgctgctttc tcttctgctc     60

ctcgcagcct cggaggtggg gagcggccag ctccactact ccgtctctga ggaggccaag    120

catggcacct tcgtgggccg catcgcgcag gacctggggc tggagctggc ggagctggtg    180

ccgcgcctgt tccgggtggc gtccaaaaga cacggggacc ttctggaggt aaatctgcag    240

aatggcattt tgtttgtgaa ttctcggata gaccgcgagg aactgtgcgg gcggagcgcg    300

gagtgcagca tccacctgga ggtgatcgtg gacaggccgc tgcaggtttt ccatgtggag    360

gtggaagtga aggacattaa tgacaacgcg ccagtttttc caatggctgt aaagaatctg    420

tttatttccg aatcccgaca gcctggctct cggttttcgc tagagggcgc atcagatgca    480

gatatcggaa caaattcgtt gttgacttac agtcttgatt ccactgaata ttttaccttg    540

gacgttaaaa gaaatgatga ggaaattaaa tcccttggac tcgtgttgaa aaaaaattta    600

aatcgagagg acactcctaa gcattattta ctaataacag caattgatgg tgggaaacca    660

gagctcactg gcacgactca actaaagatc actgttttag atgtaaacga caacgcccca    720

gcgtttgaga ggacgatcta taaagtcaga ttactcgaaa atgcaccaaa tggtacccta    780

gtggtgaccg ttaacgccac cgatttggat gaaggagtaa ataaggatat cgcgtattct    840

ttcaatacgg acatgtcagc agatattctg tcaaaattcc atttagatcc agtcaatgga    900

caaatcagtg taaagggtaa catagatttc gaggaaagta agtcatatga aatccaggta    960

gaagccacgg ataaaggaaa tcccccaatg tcagatcact gcacagttct actcgaaatt   1020

gtggacatca atgataatgt acctgagtta gttattcaat cactatcttt acctgtatta   1080

gaagactctc cacttagcac agtcatcgct ctgatcagcg tgtccgaccg cgactcagga   1140

gtcaatggac aggtcacctg ctcgctgacg ccccacgtcc ccttcaagct ggtgtccacc   1200

ttcaagaatt actactcatt ggtgctggac agccctctgg accgcgagag cgtgtcggcc   1260

tatgagctgg tggtgactgc tcgggacggg ggctcgcctt cactgtgggc cacggccagc   1320

gtgtccgtgg aggtggccga cgtgaacgac aatgcgccgg cattctcgca gtccgagtac   1380

acggtgttcg tgaaggagaa caacccgccg ggctgccaca tcttcacggt gtctgcgcgg   1440

gacgcggacg cgcaggagaa cgccctggtg tcctactcgc tggtggaacg gcgggtgggg   1500

gagcgcgcgc tgtcgagcta cgtgtcggta cacgcggaga gcggcaaggt gtacgcgctg   1560

cagccgctgg accacgagga gctagagctg ctgcagttcc aggtgagtgc gcgcgatgcg   1620

ggcgtgccgc ctctgggcag caacgtgacg ctgcaggtgt tcgtgctgga cgagaacgac   1680

aacgcgccgg cactgctgat gcctcgggtg ggtggcatcg gtggcgcagt gagcgagctg   1740

gtgccgcggt cagtgggtgc gggccacgtg gtagcgaagg tgcgcgcagt ggatgcagac   1800

tcaggctaca acgcgtggct ttcgtatgag ctgcagcctg ggaccggcgg tgcgcgcatc   1860

ccgtttcgcg tggggctgta cacgggagag atcagcacga cccgtgccct ggacgaggtg   1920

gacgccccgc gccatcgcct actggtgctg gtgaaggacc acggtgaacc ctcattgacc   1980

gccacggcca ctgtgctggt gtcgctggtg gagagtggcc aggcacccaa ggcctcgtcc   2040

caggcgtccg ctggcgccac gggcccggaa gctgcactgg tggatgtcaa cgtgtacttg   2100

atcgtcgcca tctgcgcggt gtccagtctg ttggtgctca cactgctgct atatactgct   2160

ctgcggtgct ccgcgccgcc aaccgaaggc gactgtgggc cgggcaagcc cacgctggtg   2220

tgctccagcg cggtggggag ctggtcatac tcgcagcaga ggcagcagag ggtgtgctct   2280

ggagaggggt tgcccaagac cgacctcatg gcttttagcc ctagccttcc tccttgtcca   2340

attagccggg atagagagga gaaacaggat gtggacgttg atctctcagc caaagtgagt   2400

aatttttatt tattctttcc aaaatgtctt tgtttttcat tcctcaatgt ttccactcct   2460

ctggaaatac attaa                                                    2475


<210>  220
<211>  824
<212>  PRT
<213>  Homo sapiens

<400>  220


Met Leu Phe Ser Trp Arg Glu Asp Pro Gly Ala Gln Cys Leu Leu Leu 
1               5                   10                  15      


Ser Leu Leu Leu Leu Ala Ala Ser Glu Val Gly Ser Gly Gln Leu His 
            20                  25                  30          


Tyr Ser Val Ser Glu Glu Ala Lys His Gly Thr Phe Val Gly Arg Ile 
        35                  40                  45              


Ala Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Pro Arg Leu Phe 
    50                  55                  60                  


Arg Val Ala Ser Lys Arg His Gly Asp Leu Leu Glu Val Asn Leu Gln 
65                  70                  75                  80  


Asn Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Gly Arg Ser Ala Glu Cys Ser Ile His Leu Glu Val Ile Val Asp Arg 
            100                 105                 110         


Pro Leu Gln Val Phe His Val Glu Val Glu Val Lys Asp Ile Asn Asp 
        115                 120                 125             


Asn Ala Pro Val Phe Pro Met Ala Val Lys Asn Leu Phe Ile Ser Glu 
    130                 135                 140                 


Ser Arg Gln Pro Gly Ser Arg Phe Ser Leu Glu Gly Ala Ser Asp Ala 
145                 150                 155                 160 


Asp Ile Gly Thr Asn Ser Leu Leu Thr Tyr Ser Leu Asp Ser Thr Glu 
                165                 170                 175     


Tyr Phe Thr Leu Asp Val Lys Arg Asn Asp Glu Glu Ile Lys Ser Leu 
            180                 185                 190         


Gly Leu Val Leu Lys Lys Asn Leu Asn Arg Glu Asp Thr Pro Lys His 
        195                 200                 205             


Tyr Leu Leu Ile Thr Ala Ile Asp Gly Gly Lys Pro Glu Leu Thr Gly 
    210                 215                 220                 


Thr Thr Gln Leu Lys Ile Thr Val Leu Asp Val Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Ala Phe Glu Arg Thr Ile Tyr Lys Val Arg Leu Leu Glu Asn Ala Pro 
                245                 250                 255     


Asn Gly Thr Leu Val Val Thr Val Asn Ala Thr Asp Leu Asp Glu Gly 
            260                 265                 270         


Val Asn Lys Asp Ile Ala Tyr Ser Phe Asn Thr Asp Met Ser Ala Asp 
        275                 280                 285             


Ile Leu Ser Lys Phe His Leu Asp Pro Val Asn Gly Gln Ile Ser Val 
    290                 295                 300                 


Lys Gly Asn Ile Asp Phe Glu Glu Ser Lys Ser Tyr Glu Ile Gln Val 
305                 310                 315                 320 


Glu Ala Thr Asp Lys Gly Asn Pro Pro Met Ser Asp His Cys Thr Val 
                325                 330                 335     


Leu Leu Glu Ile Val Asp Ile Asn Asp Asn Val Pro Glu Leu Val Ile 
            340                 345                 350         


Gln Ser Leu Ser Leu Pro Val Leu Glu Asp Ser Pro Leu Ser Thr Val 
        355                 360                 365             


Ile Ala Leu Ile Ser Val Ser Asp Arg Asp Ser Gly Val Asn Gly Gln 
    370                 375                 380                 


Val Thr Cys Ser Leu Thr Pro His Val Pro Phe Lys Leu Val Ser Thr 
385                 390                 395                 400 


Phe Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Pro Leu Asp Arg Glu 
                405                 410                 415     


Ser Val Ser Ala Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser 
            420                 425                 430         


Pro Ser Leu Trp Ala Thr Ala Ser Val Ser Val Glu Val Ala Asp Val 
        435                 440                 445             


Asn Asp Asn Ala Pro Ala Phe Ser Gln Ser Glu Tyr Thr Val Phe Val 
    450                 455                 460                 


Lys Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Arg 
465                 470                 475                 480 


Asp Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu 
                485                 490                 495     


Arg Arg Val Gly Glu Arg Ala Leu Ser Ser Tyr Val Ser Val His Ala 
            500                 505                 510         


Glu Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu 
        515                 520                 525             


Glu Leu Leu Gln Phe Gln Val Ser Ala Arg Asp Ala Gly Val Pro Pro 
    530                 535                 540                 


Leu Gly Ser Asn Val Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp 
545                 550                 555                 560 


Asn Ala Pro Ala Leu Leu Met Pro Arg Val Gly Gly Ile Gly Gly Ala 
                565                 570                 575     


Val Ser Glu Leu Val Pro Arg Ser Val Gly Ala Gly His Val Val Ala 
            580                 585                 590         


Lys Val Arg Ala Val Asp Ala Asp Ser Gly Tyr Asn Ala Trp Leu Ser 
        595                 600                 605             


Tyr Glu Leu Gln Pro Gly Thr Gly Gly Ala Arg Ile Pro Phe Arg Val 
    610                 615                 620                 


Gly Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Ala Leu Asp Glu Val 
625                 630                 635                 640 


Asp Ala Pro Arg His Arg Leu Leu Val Leu Val Lys Asp His Gly Glu 
                645                 650                 655     


Pro Ser Leu Thr Ala Thr Ala Thr Val Leu Val Ser Leu Val Glu Ser 
            660                 665                 670         


Gly Gln Ala Pro Lys Ala Ser Ser Gln Ala Ser Ala Gly Ala Thr Gly 
        675                 680                 685             


Pro Glu Ala Ala Leu Val Asp Val Asn Val Tyr Leu Ile Val Ala Ile 
    690                 695                 700                 


Cys Ala Val Ser Ser Leu Leu Val Leu Thr Leu Leu Leu Tyr Thr Ala 
705                 710                 715                 720 


Leu Arg Cys Ser Ala Pro Pro Thr Glu Gly Asp Cys Gly Pro Gly Lys 
                725                 730                 735     


Pro Thr Leu Val Cys Ser Ser Ala Val Gly Ser Trp Ser Tyr Ser Gln 
            740                 745                 750         


Gln Arg Gln Gln Arg Val Cys Ser Gly Glu Gly Leu Pro Lys Thr Asp 
        755                 760                 765             


Leu Met Ala Phe Ser Pro Ser Leu Pro Pro Cys Pro Ile Ser Arg Asp 
    770                 775                 780                 


Arg Glu Glu Lys Gln Asp Val Asp Val Asp Leu Ser Ala Lys Val Ser 
785                 790                 795                 800 


Asn Phe Tyr Leu Phe Phe Pro Lys Cys Leu Cys Phe Ser Phe Leu Asn 
                805                 810                 815     


Val Ser Thr Pro Leu Glu Ile His 
            820                 

<210>  221
<211>  5352
<212>  DNA
<213>  Homo sapiens

<400>  221
tgaaatatgg aggatgcagc tgcacttgac tgaccgatta aaagatttcc cttgactttg     60

agaaacgata tttaatcaga acaaaatact gtgcactaaa gatggagttt tcctggggaa    120

gcggccagga atcccggcgt ctgctgctct tacttcttct cctcgcagcc tgggaggcag    180

ggaacggtca gctccactac tcggtctccg aggaggccaa acacggcacc ttcgtgggcc    240

gcatcgcgca ggacctggga ctggagctgg cggagctggt gccgcgcctg ttccgggtgg    300

cgtccaaggg ccgcggaggc cttctggagg taaatctgca gaatggcatt ttgtttgtga    360

attctcggat cgaccgggag gagctgtgcc ggcggagcgc ggagtgcagc atccacctgg    420

aggtgatcgt agacaggccg ctgcaggttt tccatgtgga cgtggaggtg agggacatta    480

acgataaccc gccggtgttc ccagcaacac aaaagaacct gtccatcgcg gaatccaggc    540

cgcttgactc tcggtttcca ctagagggcg cctcggatgc agatatcggg gagaacgccc    600

tgctcactta cagactgagc ccaaatgaat acttttctct ggaaaaacca cctgatgacg    660

agctggtaaa aggtcttggg cttatattac ggaaatcttt agacagagaa gaagctccgg    720

agattttttt agtgctcaca gccactgatg gaggcaaacc cgagttgact ggcaccgttc    780

agttactcat cacagtactg gatgccaatg acaatgcccc agcttttgac agaaccattt    840

ataaggtgag attactagaa aatgttccta atggaacatt ggtaattaaa cttaacgcct    900

cagatttaga cgaaggattg aatggggaca ttgtttattc attctcaaat gatatttcgc    960

caaatgtgaa atccaagttt cacatagatc caattactgg acaaattatt gtaaagggat   1020

atattgactt tgaagaaagc aaatcctatg aaattattgt agagggcatt gataagggac   1080

agctcccact ttctggccat tgtagagtta ttgtggaagt agaagacaac aacgataatg   1140

tcccagattt ggaattcaag tctttatcac ttccaattag agaggacgct ccactgggta   1200

cagtcatcgc cctgatcagc gtgtccgaca aagacatggg tgtcaatggg ctggtcacct   1260

gctccttgac gtcccacgtc cccttcaagc tggtgtccac cttcaagaat tactactcgt   1320

tggtgctgga cagtgccctg gaccgcgaga gcgtgtcagc ctatgagctg gtggtgaccg   1380

cgcgagacgg gggctcgcct tcgctgtggg ccacggccag tgtttctgtg gaggtggctg   1440

atgtgaacga caacgctccg gcgttcgcgc agcccgagta cacagtgttc gtgaaggaga   1500

acaacccgcc gggctgccac atcttcactg tgtctgcgtg ggacgcggac gcgcaggaga   1560

acgcgctggt gtcctactcg ctggtagagc ggcgggtagg ggagcgcgcg ctgtcgagct   1620

acgtttcggt gcatgcggag agcggcaagg tgtacgcgct gcagccgctg gaccacgagg   1680

agctagagct gctgcagttt caggtgaccg ctcgcgatgc cggcgtgcca cctctgggca   1740

gcaacgtgac gctgcaggtg ttcgtgctgg acgaaaacga caacgcgcca gcactgctag   1800

cgcctcgggc gggtggcact ggtggcgcag tgagcgagct ggtgccatgg tcggtgggtg   1860

tgggccacgt ggtggcaaag gtgcgcgcgg tggatgctga ctcgggctac aacgcgtggc   1920

tttcgtacga gctgcagccg gggactggtg gcgcgcgcat cccgttccgc gtggggctgt   1980

acactggcga gatcagcaca acgcgtgccc tggacgaaac ggacgctccg cgccaccgcc   2040

tactggtact ggtgaaggac cacggcgagc ccgcgctgac ggccacggcc actgtgctgg   2100

tgtcacttgt ggagagtgga caggcgccaa aggcctcctc acgggcgttg gtgggcgctg   2160

tgggtcccga tgctgcgctg gtggatgtca acgtatacct gatcattgcc atctgcgcgg   2220

tgtccagcct tttggtgctc acgctgctgc tgtacaccgc gctgcggtgc tctgcgctgc   2280

ccaccgaggg cgcgtgcgct ccgggcaagc ccacgctggt gtgctccagt gcggtgggga   2340

gctggtcata ctcgcagcag aggaggccga gggtgtgctc tggtgagggc ccacccaaga   2400

ccgacctcat ggccttcagc cccagtttac ctgactctag ggacagagaa gatcagctgc   2460

agacaactga ggaatccttt gcaaagccac gacagcccaa ccctgactgg cgttactctg   2520

cctccctgag agcaggcatg cacagctctg tgcacctaga ggaggctggc attctacggg   2580

ctggtccagg agggcctgat cagcagtggc caacagtatc cagtgcaaca ccagaaccag   2640

aggcaggaga agtgtcccct ccagtcggtg cgggtgtcaa cagcaacagc tggaccttta   2700

aatacggacc aggcaacccc aaacaatccg gtcccggtga gttgcccgac aaattcatta   2760

tcccaggatc tcctgcaatc atctccatcc ggcaggagcc tactaacagc caaattgaca   2820

aaagtgactt cataaccttc ggcaaaaagg aggagaccaa gaaaaagaag aaaaagaaga   2880

agggtaacaa gacccaggag aaaaaagaga aagggaacag cacgactgac aacagtgacc   2940

agtgaggtcc tcaaatggaa acaagccact tagccagttt ttgtaataat ggcaaatctc   3000

tcccatgtag caattccctg ctcctttttc ctatctacat gagccctctt agagacctca   3060

gaaatctgca gaaagttccc tgtgtctgtc tagaacgcat ttaacaggtt ttgtcgtaaa   3120

agctttacta agtctggtgt taactctttc tctccactct ggcttgtttt cagaacctaa   3180

aaagcagacc caagtttcct ttctcctccg ccgcaaagga gaggcttccc agccccgcca   3240

gtgagaggtt ggactctctg ccctgtgctc cggggatcct gtcttgatga cacttgcagg   3300

gcaggctgaa aagttttgag attgagcagc ttgggagttt gtggccactg ggtatgtgtg   3360

gctaccgcgg gtatgcgagt gccagatatt ggctgagacg agccagctta gactaattgg   3420

tacaaggaag gcaagaaaac aaagacaaat aaacagcgga agttatcagt atggagggga   3480

agtgtaaact taaagggacc agactttcta aatcttacaa ctcaagaggt ggcagccacc   3540

ctctaggaga caaaactacc cccactgaca aggctttagg agaccctaaa gtctgttggc   3600

tgtgacgtca ttatacctaa aatctgcatc atacctgcaa gccaacagtt cagtgtttta   3660

acagagaacc accctgggaa acagaagcag atctgatgtg tttcctatac atgtcctgtg   3720

ctcactttat taaaaattct tttgcacaca atgtttatga aaaggccaga tccttttcca   3780

atacttatgc aaaagcaaaa gaaaaccccg acacctcacc tttcgctgtt tgttgtttca   3840

tagatttatt taaaaaaaga gaaagtctat agctataaat ctttaaagag aaatatgaat   3900

acaattcccc taaactctcc tcaaaagaga attcagtcta cagccattta aatgatcatt   3960

gctgctacag aagtgcttta agagaattgc ctgaaacatc tgtattatat cggccacctg   4020

ccaatcacag ctttactctt tcaggtcact ctggggctgc ctcttgcatg tattactaaa   4080

taaaatgatc tctctttctc tctctctctc tcttttctaa gaaacaatta tgtgcacttt   4140

gatacacaac cttctctaac caactatata tcaagaccca aaaattgaag aaaaatattg   4200

ttttctcata cagtgagcag atttttcaat ctactaattc tgtgacttgt cttggtgtgc   4260

tagcctacac cttctctttg gtttagtttt ccttttctat aacactctga attgctaatc   4320

ttactaacac ctatgatgtt acctgaaatc aatctcccat atgtatgctg tatgctatgc   4380

taagactcct gaaatatact tactctgtgc ttgtgtatgt gaatgttaat gcaactatta   4440

cctagagtga actttaagct ttattgttga atgtaattcc attatatttc cttttgtaca   4500

cctgtgaaaa agtggagtag tgttttttta accattgtta atcagctttt gtgtatgaaa   4560

gacacagtaa aatttctttc ttaaatcaag atactggtga ttcaaggaat tttatttatg   4620

gtccagccaa gagccatctc gtgccaagac ttctgctggc aagggaatgg ataaagctgt   4680

tttgttctag taacaatttt ggaatgaata ctgacaatat tccatgaggg tgtgcaagca   4740

caaattttac caatctgacc tctttgaagt tgcagaatgc tttgaaattc taatggtatc   4800

tgaaatatca gctcatagaa agtaacaaaa tttgctgtca ccttaaataa gacattttaa   4860

ttttgttata atgtacaatt tagaagtttg attaattata ttatctattt aggcattaat   4920

ataaaagagg taggagtctg ttatttaaaa aaagcattaa atttaaaaaa aaactgtctt   4980

gtctactttt agcttcattc tcccatattt tgaagggtgt gtaacttcag ctctgcagga   5040

ttgcatgggg taaaacttgt taccaacaca tgtgaaccat tgctacattg taggttgtga   5100

tcattttgcc ccactgaagc ccatgtatct gaccttacgt gccttttgaa ctaggagaat   5160

cgggctaatt tattaatgat gataattata atgtatctgt acagcacttt ttacatttgc   5220

gaagtgcttt ccaatccatg ttagttacta gttattacag ctgtaaggat aaaacacgtc   5280

atgtggattc attttgaatt ggtgctattg gtatttcctc tgttattgct aataaatgaa   5340

aatggtggta tg                                                       5352


<210>  222
<211>  947
<212>  PRT
<213>  Homo sapiens

<400>  222


Met Glu Phe Ser Trp Gly Ser Gly Gln Glu Ser Arg Arg Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Ala Ala Trp Glu Ala Gly Asn Gly Gln Leu His 
            20                  25                  30          


Tyr Ser Val Ser Glu Glu Ala Lys His Gly Thr Phe Val Gly Arg Ile 
        35                  40                  45              


Ala Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Pro Arg Leu Phe 
    50                  55                  60                  


Arg Val Ala Ser Lys Gly Arg Gly Gly Leu Leu Glu Val Asn Leu Gln 
65                  70                  75                  80  


Asn Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Arg Arg Ser Ala Glu Cys Ser Ile His Leu Glu Val Ile Val Asp Arg 
            100                 105                 110         


Pro Leu Gln Val Phe His Val Asp Val Glu Val Arg Asp Ile Asn Asp 
        115                 120                 125             


Asn Pro Pro Val Phe Pro Ala Thr Gln Lys Asn Leu Ser Ile Ala Glu 
    130                 135                 140                 


Ser Arg Pro Leu Asp Ser Arg Phe Pro Leu Glu Gly Ala Ser Asp Ala 
145                 150                 155                 160 


Asp Ile Gly Glu Asn Ala Leu Leu Thr Tyr Arg Leu Ser Pro Asn Glu 
                165                 170                 175     


Tyr Phe Ser Leu Glu Lys Pro Pro Asp Asp Glu Leu Val Lys Gly Leu 
            180                 185                 190         


Gly Leu Ile Leu Arg Lys Ser Leu Asp Arg Glu Glu Ala Pro Glu Ile 
        195                 200                 205             


Phe Leu Val Leu Thr Ala Thr Asp Gly Gly Lys Pro Glu Leu Thr Gly 
    210                 215                 220                 


Thr Val Gln Leu Leu Ile Thr Val Leu Asp Ala Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Ala Phe Asp Arg Thr Ile Tyr Lys Val Arg Leu Leu Glu Asn Val Pro 
                245                 250                 255     


Asn Gly Thr Leu Val Ile Lys Leu Asn Ala Ser Asp Leu Asp Glu Gly 
            260                 265                 270         


Leu Asn Gly Asp Ile Val Tyr Ser Phe Ser Asn Asp Ile Ser Pro Asn 
        275                 280                 285             


Val Lys Ser Lys Phe His Ile Asp Pro Ile Thr Gly Gln Ile Ile Val 
    290                 295                 300                 


Lys Gly Tyr Ile Asp Phe Glu Glu Ser Lys Ser Tyr Glu Ile Ile Val 
305                 310                 315                 320 


Glu Gly Ile Asp Lys Gly Gln Leu Pro Leu Ser Gly His Cys Arg Val 
                325                 330                 335     


Ile Val Glu Val Glu Asp Asn Asn Asp Asn Val Pro Asp Leu Glu Phe 
            340                 345                 350         


Lys Ser Leu Ser Leu Pro Ile Arg Glu Asp Ala Pro Leu Gly Thr Val 
        355                 360                 365             


Ile Ala Leu Ile Ser Val Ser Asp Lys Asp Met Gly Val Asn Gly Leu 
    370                 375                 380                 


Val Thr Cys Ser Leu Thr Ser His Val Pro Phe Lys Leu Val Ser Thr 
385                 390                 395                 400 


Phe Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu 
                405                 410                 415     


Ser Val Ser Ala Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser 
            420                 425                 430         


Pro Ser Leu Trp Ala Thr Ala Ser Val Ser Val Glu Val Ala Asp Val 
        435                 440                 445             


Asn Asp Asn Ala Pro Ala Phe Ala Gln Pro Glu Tyr Thr Val Phe Val 
    450                 455                 460                 


Lys Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Trp 
465                 470                 475                 480 


Asp Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu 
                485                 490                 495     


Arg Arg Val Gly Glu Arg Ala Leu Ser Ser Tyr Val Ser Val His Ala 
            500                 505                 510         


Glu Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu 
        515                 520                 525             


Glu Leu Leu Gln Phe Gln Val Thr Ala Arg Asp Ala Gly Val Pro Pro 
    530                 535                 540                 


Leu Gly Ser Asn Val Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp 
545                 550                 555                 560 


Asn Ala Pro Ala Leu Leu Ala Pro Arg Ala Gly Gly Thr Gly Gly Ala 
                565                 570                 575     


Val Ser Glu Leu Val Pro Trp Ser Val Gly Val Gly His Val Val Ala 
            580                 585                 590         


Lys Val Arg Ala Val Asp Ala Asp Ser Gly Tyr Asn Ala Trp Leu Ser 
        595                 600                 605             


Tyr Glu Leu Gln Pro Gly Thr Gly Gly Ala Arg Ile Pro Phe Arg Val 
    610                 615                 620                 


Gly Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Ala Leu Asp Glu Thr 
625                 630                 635                 640 


Asp Ala Pro Arg His Arg Leu Leu Val Leu Val Lys Asp His Gly Glu 
                645                 650                 655     


Pro Ala Leu Thr Ala Thr Ala Thr Val Leu Val Ser Leu Val Glu Ser 
            660                 665                 670         


Gly Gln Ala Pro Lys Ala Ser Ser Arg Ala Leu Val Gly Ala Val Gly 
        675                 680                 685             


Pro Asp Ala Ala Leu Val Asp Val Asn Val Tyr Leu Ile Ile Ala Ile 
    690                 695                 700                 


Cys Ala Val Ser Ser Leu Leu Val Leu Thr Leu Leu Leu Tyr Thr Ala 
705                 710                 715                 720 


Leu Arg Cys Ser Ala Leu Pro Thr Glu Gly Ala Cys Ala Pro Gly Lys 
                725                 730                 735     


Pro Thr Leu Val Cys Ser Ser Ala Val Gly Ser Trp Ser Tyr Ser Gln 
            740                 745                 750         


Gln Arg Arg Pro Arg Val Cys Ser Gly Glu Gly Pro Pro Lys Thr Asp 
        755                 760                 765             


Leu Met Ala Phe Ser Pro Ser Leu Pro Asp Ser Arg Asp Arg Glu Asp 
    770                 775                 780                 


Gln Leu Gln Thr Thr Glu Glu Ser Phe Ala Lys Pro Arg Gln Pro Asn 
785                 790                 795                 800 


Pro Asp Trp Arg Tyr Ser Ala Ser Leu Arg Ala Gly Met His Ser Ser 
                805                 810                 815     


Val His Leu Glu Glu Ala Gly Ile Leu Arg Ala Gly Pro Gly Gly Pro 
            820                 825                 830         


Asp Gln Gln Trp Pro Thr Val Ser Ser Ala Thr Pro Glu Pro Glu Ala 
        835                 840                 845             


Gly Glu Val Ser Pro Pro Val Gly Ala Gly Val Asn Ser Asn Ser Trp 
    850                 855                 860                 


Thr Phe Lys Tyr Gly Pro Gly Asn Pro Lys Gln Ser Gly Pro Gly Glu 
865                 870                 875                 880 


Leu Pro Asp Lys Phe Ile Ile Pro Gly Ser Pro Ala Ile Ile Ser Ile 
                885                 890                 895     


Arg Gln Glu Pro Thr Asn Ser Gln Ile Asp Lys Ser Asp Phe Ile Thr 
            900                 905                 910         


Phe Gly Lys Lys Glu Glu Thr Lys Lys Lys Lys Lys Lys Lys Lys Gly 
        915                 920                 925             


Asn Lys Thr Gln Glu Lys Lys Glu Lys Gly Asn Ser Thr Thr Asp Asn 
    930                 935                 940                 


Ser Asp Gln 
945         

<210>  223
<211>  2498
<212>  DNA
<213>  Homo sapiens

<400>  223
tgaaatatgg aggatgcagc tgcacttgac tgaccgatta aaagatttcc cttgactttg     60

agaaacgata tttaatcaga acaaaatact gtgcactaaa gatggagttt tcctggggaa    120

gcggccagga atcccggcgt ctgctgctct tacttcttct cctcgcagcc tgggaggcag    180

ggaacggtca gctccactac tcggtctccg aggaggccaa acacggcacc ttcgtgggcc    240

gcatcgcgca ggacctggga ctggagctgg cggagctggt gccgcgcctg ttccgggtgg    300

cgtccaaggg ccgcggaggc cttctggagg taaatctgca gaatggcatt ttgtttgtga    360

attctcggat cgaccgggag gagctgtgcc ggcggagcgc ggagtgcagc atccacctgg    420

aggtgatcgt agacaggccg ctgcaggttt tccatgtgga cgtggaggtg agggacatta    480

acgataaccc gccggtgttc ccagcaacac aaaagaacct gtccatcgcg gaatccaggc    540

cgcttgactc tcggtttcca ctagagggcg cctcggatgc agatatcggg gagaacgccc    600

tgctcactta cagactgagc ccaaatgaat acttttctct ggaaaaacca cctgatgacg    660

agctggtaaa aggtcttggg cttatattac ggaaatcttt agacagagaa gaagctccgg    720

agattttttt agtgctcaca gccactgatg gaggcaaacc cgagttgact ggcaccgttc    780

agttactcat cacagtactg gatgccaatg acaatgcccc agcttttgac agaaccattt    840

ataaggtgag attactagaa aatgttccta atggaacatt ggtaattaaa cttaacgcct    900

cagatttaga cgaaggattg aatggggaca ttgtttattc attctcaaat gatatttcgc    960

caaatgtgaa atccaagttt cacatagatc caattactgg acaaattatt gtaaagggat   1020

atattgactt tgaagaaagc aaatcctatg aaattattgt agagggcatt gataagggac   1080

agctcccact ttctggccat tgtagagtta ttgtggaagt agaagacaac aacgataatg   1140

tcccagattt ggaattcaag tctttatcac ttccaattag agaggacgct ccactgggta   1200

cagtcatcgc cctgatcagc gtgtccgaca aagacatggg tgtcaatggg ctggtcacct   1260

gctccttgac gtcccacgtc cccttcaagc tggtgtccac cttcaagaat tactactcgt   1320

tggtgctgga cagtgccctg gaccgcgaga gcgtgtcagc ctatgagctg gtggtgaccg   1380

cgcgagacgg gggctcgcct tcgctgtggg ccacggccag tgtttctgtg gaggtggctg   1440

atgtgaacga caacgctccg gcgttcgcgc agcccgagta cacagtgttc gtgaaggaga   1500

acaacccgcc gggctgccac atcttcactg tgtctgcgtg ggacgcggac gcgcaggaga   1560

acgcgctggt gtcctactcg ctggtagagc ggcgggtagg ggagcgcgcg ctgtcgagct   1620

acgtttcggt gcatgcggag agcggcaagg tgtacgcgct gcagccgctg gaccacgagg   1680

agctagagct gctgcagttt caggtgaccg ctcgcgatgc cggcgtgcca cctctgggca   1740

gcaacgtgac gctgcaggtg ttcgtgctgg acgaaaacga caacgcgcca gcactgctag   1800

cgcctcgggc gggtggcact ggtggcgcag tgagcgagct ggtgccatgg tcggtgggtg   1860

tgggccacgt ggtggcaaag gtgcgcgcgg tggatgctga ctcgggctac aacgcgtggc   1920

tttcgtacga gctgcagccg gggactggtg gcgcgcgcat cccgttccgc gtggggctgt   1980

acactggcga gatcagcaca acgcgtgccc tggacgaaac ggacgctccg cgccaccgcc   2040

tactggtact ggtgaaggac cacggcgagc ccgcgctgac ggccacggcc actgtgctgg   2100

tgtcacttgt ggagagtgga caggcgccaa aggcctcctc acgggcgttg gtgggcgctg   2160

tgggtcccga tgctgcgctg gtggatgtca acgtatacct gatcattgcc atctgcgcgg   2220

tgtccagcct tttggtgctc acgctgctgc tgtacaccgc gctgcggtgc tctgcgctgc   2280

ccaccgaggg cgcgtgcgct ccgggcaagc ccacgctggt gtgctccagt gcggtgggga   2340

gctggtcata ctcgcagcag aggaggccga gggtgtgctc tggtgagggc ccacccaaga   2400

ccgacctcat ggccttcagc cccagtttac ctgactctag ggacagagaa gatcagctgc   2460

agacaactga ggaatccttt gcaaaggtta gtgtataa                           2498


<210>  224
<211>  798
<212>  PRT
<213>  Homo sapiens

<400>  224


Met Glu Phe Ser Trp Gly Ser Gly Gln Glu Ser Arg Arg Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Ala Ala Trp Glu Ala Gly Asn Gly Gln Leu His 
            20                  25                  30          


Tyr Ser Val Ser Glu Glu Ala Lys His Gly Thr Phe Val Gly Arg Ile 
        35                  40                  45              


Ala Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Pro Arg Leu Phe 
    50                  55                  60                  


Arg Val Ala Ser Lys Gly Arg Gly Gly Leu Leu Glu Val Asn Leu Gln 
65                  70                  75                  80  


Asn Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Arg Arg Ser Ala Glu Cys Ser Ile His Leu Glu Val Ile Val Asp Arg 
            100                 105                 110         


Pro Leu Gln Val Phe His Val Asp Val Glu Val Arg Asp Ile Asn Asp 
        115                 120                 125             


Asn Pro Pro Val Phe Pro Ala Thr Gln Lys Asn Leu Ser Ile Ala Glu 
    130                 135                 140                 


Ser Arg Pro Leu Asp Ser Arg Phe Pro Leu Glu Gly Ala Ser Asp Ala 
145                 150                 155                 160 


Asp Ile Gly Glu Asn Ala Leu Leu Thr Tyr Arg Leu Ser Pro Asn Glu 
                165                 170                 175     


Tyr Phe Ser Leu Glu Lys Pro Pro Asp Asp Glu Leu Val Lys Gly Leu 
            180                 185                 190         


Gly Leu Ile Leu Arg Lys Ser Leu Asp Arg Glu Glu Ala Pro Glu Ile 
        195                 200                 205             


Phe Leu Val Leu Thr Ala Thr Asp Gly Gly Lys Pro Glu Leu Thr Gly 
    210                 215                 220                 


Thr Val Gln Leu Leu Ile Thr Val Leu Asp Ala Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Ala Phe Asp Arg Thr Ile Tyr Lys Val Arg Leu Leu Glu Asn Val Pro 
                245                 250                 255     


Asn Gly Thr Leu Val Ile Lys Leu Asn Ala Ser Asp Leu Asp Glu Gly 
            260                 265                 270         


Leu Asn Gly Asp Ile Val Tyr Ser Phe Ser Asn Asp Ile Ser Pro Asn 
        275                 280                 285             


Val Lys Ser Lys Phe His Ile Asp Pro Ile Thr Gly Gln Ile Ile Val 
    290                 295                 300                 


Lys Gly Tyr Ile Asp Phe Glu Glu Ser Lys Ser Tyr Glu Ile Ile Val 
305                 310                 315                 320 


Glu Gly Ile Asp Lys Gly Gln Leu Pro Leu Ser Gly His Cys Arg Val 
                325                 330                 335     


Ile Val Glu Val Glu Asp Asn Asn Asp Asn Val Pro Asp Leu Glu Phe 
            340                 345                 350         


Lys Ser Leu Ser Leu Pro Ile Arg Glu Asp Ala Pro Leu Gly Thr Val 
        355                 360                 365             


Ile Ala Leu Ile Ser Val Ser Asp Lys Asp Met Gly Val Asn Gly Leu 
    370                 375                 380                 


Val Thr Cys Ser Leu Thr Ser His Val Pro Phe Lys Leu Val Ser Thr 
385                 390                 395                 400 


Phe Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu 
                405                 410                 415     


Ser Val Ser Ala Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser 
            420                 425                 430         


Pro Ser Leu Trp Ala Thr Ala Ser Val Ser Val Glu Val Ala Asp Val 
        435                 440                 445             


Asn Asp Asn Ala Pro Ala Phe Ala Gln Pro Glu Tyr Thr Val Phe Val 
    450                 455                 460                 


Lys Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Trp 
465                 470                 475                 480 


Asp Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu 
                485                 490                 495     


Arg Arg Val Gly Glu Arg Ala Leu Ser Ser Tyr Val Ser Val His Ala 
            500                 505                 510         


Glu Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu 
        515                 520                 525             


Glu Leu Leu Gln Phe Gln Val Thr Ala Arg Asp Ala Gly Val Pro Pro 
    530                 535                 540                 


Leu Gly Ser Asn Val Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp 
545                 550                 555                 560 


Asn Ala Pro Ala Leu Leu Ala Pro Arg Ala Gly Gly Thr Gly Gly Ala 
                565                 570                 575     


Val Ser Glu Leu Val Pro Trp Ser Val Gly Val Gly His Val Val Ala 
            580                 585                 590         


Lys Val Arg Ala Val Asp Ala Asp Ser Gly Tyr Asn Ala Trp Leu Ser 
        595                 600                 605             


Tyr Glu Leu Gln Pro Gly Thr Gly Gly Ala Arg Ile Pro Phe Arg Val 
    610                 615                 620                 


Gly Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Ala Leu Asp Glu Thr 
625                 630                 635                 640 


Asp Ala Pro Arg His Arg Leu Leu Val Leu Val Lys Asp His Gly Glu 
                645                 650                 655     


Pro Ala Leu Thr Ala Thr Ala Thr Val Leu Val Ser Leu Val Glu Ser 
            660                 665                 670         


Gly Gln Ala Pro Lys Ala Ser Ser Arg Ala Leu Val Gly Ala Val Gly 
        675                 680                 685             


Pro Asp Ala Ala Leu Val Asp Val Asn Val Tyr Leu Ile Ile Ala Ile 
    690                 695                 700                 


Cys Ala Val Ser Ser Leu Leu Val Leu Thr Leu Leu Leu Tyr Thr Ala 
705                 710                 715                 720 


Leu Arg Cys Ser Ala Leu Pro Thr Glu Gly Ala Cys Ala Pro Gly Lys 
                725                 730                 735     


Pro Thr Leu Val Cys Ser Ser Ala Val Gly Ser Trp Ser Tyr Ser Gln 
            740                 745                 750         


Gln Arg Arg Pro Arg Val Cys Ser Gly Glu Gly Pro Pro Lys Thr Asp 
        755                 760                 765             


Leu Met Ala Phe Ser Pro Ser Leu Pro Asp Ser Arg Asp Arg Glu Asp 
    770                 775                 780                 


Gln Leu Gln Thr Thr Glu Glu Ser Phe Ala Lys Val Ser Val 
785                 790                 795             

<210>  225
<211>  5218
<212>  DNA
<213>  Homo sapiens

<400>  225
atggtatatt cccggagagg aagtctggga tcccggctcc tgctgctctg gcttctcctt     60

gcctactgga aggcagggag cggccagctc cactactcga tcccggagga agccaaacac    120

ggaaccttcg ttggccgcat cgcgcaggac ctagggctgg agctggcgga gctggtgccg    180

cgcctgttcc gggtggcgtc caagggccgc ggggaccttc tggaggtaaa tctgcagaat    240

ggcattttgt ttgtgaattc tcggatcgac cgggaggagc tgtgccggcg gagggcggag    300

tgcagcatcc acctggaggt gatcgtggac aggccgctgc aggttttcca tgtggaggtg    360

gcagtgaagg acatcaatga caatccgccc aggttctcca gacaagaaca aagattattc    420

attttagagt caagaatgcc agattcgcgg tttccgctag agggcgcgtc ggatttggat    480

attggagcaa atgcacaatt gagatacagg ttaaatccaa acgaatattt tgacttagat    540

gttaaaacaa atgaagaaga aacgaacttt ttagagctgg ttttgaggaa atccttagat    600

agagaagaaa cacaagaaca ccgtttatta gtgattgcaa ctgatggagg aaaacccgaa    660

ctaacaggta cagttcagtt gttgatcaat gtattggatg ctaatgataa cgccccagaa    720

tttgataaat ccatttataa tgtcagattg ttggaaaatg caccaagtgg gacattagtt    780

attaaactga acgcctcaga tgcagatgag ggcatcaata aggaaatagt gtatttcttt    840

agtaatcttg ttcttgacga tgtaaagtcc aaatttataa ttaattctaa tactggtgaa    900

ataaaagtta acggggaact ggattatgaa gactataact catatgaaat taatattgat    960

gccatggata aaagtacatt cccattatca ggacactgta aagtagtagt gaaactcctg   1020

gatgtgaatg ataatacccc agagatggcc ataaccaccc ttttcctgcc tgtcaaagag   1080

gacgctccac tcagcacggt cattgctctg atcagcgtgt ctgaccgtga ctcaggtgcc   1140

aacgggcagg tgacctgctc cctaatgccc cacgttccct tcaagctggt gtccaccttc   1200

aagaattact actcgttggt gctggacagc gccctggacc gcgagagcgt gtcggtctat   1260

gagctggtgg tgaccgcgcg ggacgggggc tcgccttcgc tgtgggccac cgccagcgtg   1320

tctgtggaag tggccgacgt gaacgacaac gctccggcgt tcgcgcagcc ccagtatacc   1380

gtgttcgtga aggagaacaa cccgccaggc tgccacatct tcacggtgtc tgcacgggac   1440

gcggacgcgc aggagaacgc cctggtgtcc tactcgctgg tggagcggcg ggtgggcgag   1500

cgcccgctgt cgagttacgt ttcggtgcac gcggagagcg gcaaggtgta cgcgctgcag   1560

ccgctggacc acgaggaagt ggagctgctg cagttccagg tgagcgcgcg cgacgcgggc   1620

gtgccgcctc tgggcagcaa cgtgacgctg caggtgttcg tgctggacga gaacgacaac   1680

gcgccggcgc tgctggtgcc tcgagtgggt ggcaccggcg gcgcagtgag cgagctggtg   1740

ccgaggtcag tgggtgcggg ccacgtggtg gcgaaggtgc gcgcagtgga ccctgattcg   1800

ggctacaacg cttggctttc gtatgagctg cagccagcgc ctggcagtgc gcgcatcccg   1860

ttccgcgtgg ggctgtacac aggcgagatc agcacaacac gctctctgga tgagaccgaa   1920

gcaccgcgcc accgccttct ggtgctggtg aaggaccatg gagagccccc gctgacagcc   1980

acagccacag tgctggtgtc gctggtggaa agtggccagg cgccgaaggc ctcatcgcgg   2040

gcgtcggcgg gcgctgtggg tcccgaggct gccctggtgg atgtcaacgt gtacctgatc   2100

atcgccatct gtgcggtgtc cagcctgctg gtgctcacgc tgctgctgta caccgcgctg   2160

cggtgctcgg cgcagcccac cgaggccgtg tgcacacggg gcaagcccac tctgttgtgc   2220

tccagcgcgg tggggagctg gtcgtactcg cagcagagga gacagagggt gtgctctggg   2280

gaagctccac ccaaaacaga cctcatggcc ttcagtccaa gccttcctca gggtcccacc   2340

tctacagaca acccacgaca gcccaaccct gactggcgtt actctgcctc cctgagagca   2400

ggcatgcaca gctctgtgca cctagaggag gctggcattc tacgggctgg tccaggaggg   2460

cctgatcagc agtggccaac agtatccagt gcaacaccag aaccagaggc aggagaagtg   2520

tcccctccag tcggtgcggg tgtcaacagc aacagctgga cctttaaata cggaccaggc   2580

aaccccaaac aatccggtcc cggtgagttg cccgacaaat tcattatccc aggatctcct   2640

gcaatcatct ccatccggca ggagcctact aacagccaaa ttgacaaaag tgacttcata   2700

accttcggca aaaaggagga gaccaagaaa aagaagaaaa agaagaaggg taacaagacc   2760

caggagaaaa aagagaaagg gaacagcacg actgacaaca gtgaccagtg aggtcctcaa   2820

atggaaacaa gccacttagc cagtttttgt aataatggca aatctctccc atgtagcaat   2880

tccctgctcc tttttcctat ctacatgagc cctcttagag acctcagaaa tctgcagaaa   2940

gttccctgtg tctgtctaga acgcatttaa caggttttgt cgtaaaagct ttactaagtc   3000

tggtgttaac tctttctctc cactctggct tgttttcaga acctaaaaag cagacccaag   3060

tttcctttct cctccgccgc aaaggagagg cttcccagcc ccgccagtga gaggttggac   3120

tctctgccct gtgctccggg gatcctgtct tgatgacact tgcagggcag gctgaaaagt   3180

tttgagattg agcagcttgg gagtttgtgg ccactgggta tgtgtggcta ccgcgggtat   3240

gcgagtgcca gatattggct gagacgagcc agcttagact aattggtaca aggaaggcaa   3300

gaaaacaaag acaaataaac agcggaagtt atcagtatgg aggggaagtg taaacttaaa   3360

gggaccagac tttctaaatc ttacaactca agaggtggca gccaccctct aggagacaaa   3420

actaccccca ctgacaaggc tttaggagac cctaaagtct gttggctgtg acgtcattat   3480

acctaaaatc tgcatcatac ctgcaagcca acagttcagt gttttaacag agaaccaccc   3540

tgggaaacag aagcagatct gatgtgtttc ctatacatgt cctgtgctca ctttattaaa   3600

aattcttttg cacacaatgt ttatgaaaag gccagatcct tttccaatac ttatgcaaaa   3660

gcaaaagaaa accccgacac ctcacctttc gctgtttgtt gtttcataga tttatttaaa   3720

aaaagagaaa gtctatagct ataaatcttt aaagagaaat atgaatacaa ttcccctaaa   3780

ctctcctcaa aagagaattc agtctacagc catttaaatg atcattgctg ctacagaagt   3840

gctttaagag aattgcctga aacatctgta ttatatcggc cacctgccaa tcacagcttt   3900

actctttcag gtcactctgg ggctgcctct tgcatgtatt actaaataaa atgatctctc   3960

tttctctctc tctctctctt ttctaagaaa caattatgtg cactttgata cacaaccttc   4020

tctaaccaac tatatatcaa gacccaaaaa ttgaagaaaa atattgtttt ctcatacagt   4080

gagcagattt ttcaatctac taattctgtg acttgtcttg gtgtgctagc ctacaccttc   4140

tctttggttt agttttcctt ttctataaca ctctgaattg ctaatcttac taacacctat   4200

gatgttacct gaaatcaatc tcccatatgt atgctgtatg ctatgctaag actcctgaaa   4260

tatacttact ctgtgcttgt gtatgtgaat gttaatgcaa ctattaccta gagtgaactt   4320

taagctttat tgttgaatgt aattccatta tatttccttt tgtacacctg tgaaaaagtg   4380

gagtagtgtt tttttaacca ttgttaatca gcttttgtgt atgaaagaca cagtaaaatt   4440

tctttcttaa atcaagatac tggtgattca aggaatttta tttatggtcc agccaagagc   4500

catctcgtgc caagacttct gctggcaagg gaatggataa agctgttttg ttctagtaac   4560

aattttggaa tgaatactga caatattcca tgagggtgtg caagcacaaa ttttaccaat   4620

ctgacctctt tgaagttgca gaatgctttg aaattctaat ggtatctgaa atatcagctc   4680

atagaaagta acaaaatttg ctgtcacctt aaataagaca ttttaatttt gttataatgt   4740

acaatttaga agtttgatta attatattat ctatttaggc attaatataa aagaggtagg   4800

agtctgttat ttaaaaaaag cattaaattt aaaaaaaaac tgtcttgtct acttttagct   4860

tcattctccc atattttgaa gggtgtgtaa cttcagctct gcaggattgc atggggtaaa   4920

acttgttacc aacacatgtg aaccattgct acattgtagg ttgtgatcat tttgccccac   4980

tgaagcccat gtatctgacc ttacgtgcct tttgaactag gagaatcggg ctaatttatt   5040

aatgatgata attataatgt atctgtacag cactttttac atttgcgaag tgctttccaa   5100

tccatgttag ttactagtta ttacagctgt aaggataaaa cacgtcatgt ggattcattt   5160

tgaattggtg ctattggtat ttcctctgtt attgctaata aatgaaaatg gtggtatg     5218


<210>  226
<211>  936
<212>  PRT
<213>  Homo sapiens

<400>  226


Met Val Tyr Ser Arg Arg Gly Ser Leu Gly Ser Arg Leu Leu Leu Leu 
1               5                   10                  15      


Trp Leu Leu Leu Ala Tyr Trp Lys Ala Gly Ser Gly Gln Leu His Tyr 
            20                  25                  30          


Ser Ile Pro Glu Glu Ala Lys His Gly Thr Phe Val Gly Arg Ile Ala 
        35                  40                  45              


Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Pro Arg Leu Phe Arg 
    50                  55                  60                  


Val Ala Ser Lys Gly Arg Gly Asp Leu Leu Glu Val Asn Leu Gln Asn 
65                  70                  75                  80  


Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys Arg 
                85                  90                  95      


Arg Arg Ala Glu Cys Ser Ile His Leu Glu Val Ile Val Asp Arg Pro 
            100                 105                 110         


Leu Gln Val Phe His Val Glu Val Ala Val Lys Asp Ile Asn Asp Asn 
        115                 120                 125             


Pro Pro Arg Phe Ser Arg Gln Glu Gln Arg Leu Phe Ile Leu Glu Ser 
    130                 135                 140                 


Arg Met Pro Asp Ser Arg Phe Pro Leu Glu Gly Ala Ser Asp Leu Asp 
145                 150                 155                 160 


Ile Gly Ala Asn Ala Gln Leu Arg Tyr Arg Leu Asn Pro Asn Glu Tyr 
                165                 170                 175     


Phe Asp Leu Asp Val Lys Thr Asn Glu Glu Glu Thr Asn Phe Leu Glu 
            180                 185                 190         


Leu Val Leu Arg Lys Ser Leu Asp Arg Glu Glu Thr Gln Glu His Arg 
        195                 200                 205             


Leu Leu Val Ile Ala Thr Asp Gly Gly Lys Pro Glu Leu Thr Gly Thr 
    210                 215                 220                 


Val Gln Leu Leu Ile Asn Val Leu Asp Ala Asn Asp Asn Ala Pro Glu 
225                 230                 235                 240 


Phe Asp Lys Ser Ile Tyr Asn Val Arg Leu Leu Glu Asn Ala Pro Ser 
                245                 250                 255     


Gly Thr Leu Val Ile Lys Leu Asn Ala Ser Asp Ala Asp Glu Gly Ile 
            260                 265                 270         


Asn Lys Glu Ile Val Tyr Phe Phe Ser Asn Leu Val Leu Asp Asp Val 
        275                 280                 285             


Lys Ser Lys Phe Ile Ile Asn Ser Asn Thr Gly Glu Ile Lys Val Asn 
    290                 295                 300                 


Gly Glu Leu Asp Tyr Glu Asp Tyr Asn Ser Tyr Glu Ile Asn Ile Asp 
305                 310                 315                 320 


Ala Met Asp Lys Ser Thr Phe Pro Leu Ser Gly His Cys Lys Val Val 
                325                 330                 335     


Val Lys Leu Leu Asp Val Asn Asp Asn Thr Pro Glu Met Ala Ile Thr 
            340                 345                 350         


Thr Leu Phe Leu Pro Val Lys Glu Asp Ala Pro Leu Ser Thr Val Ile 
        355                 360                 365             


Ala Leu Ile Ser Val Ser Asp Arg Asp Ser Gly Ala Asn Gly Gln Val 
    370                 375                 380                 


Thr Cys Ser Leu Met Pro His Val Pro Phe Lys Leu Val Ser Thr Phe 
385                 390                 395                 400 


Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu Ser 
                405                 410                 415     


Val Ser Val Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser Pro 
            420                 425                 430         


Ser Leu Trp Ala Thr Ala Ser Val Ser Val Glu Val Ala Asp Val Asn 
        435                 440                 445             


Asp Asn Ala Pro Ala Phe Ala Gln Pro Gln Tyr Thr Val Phe Val Lys 
    450                 455                 460                 


Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Arg Asp 
465                 470                 475                 480 


Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu Arg 
                485                 490                 495     


Arg Val Gly Glu Arg Pro Leu Ser Ser Tyr Val Ser Val His Ala Glu 
            500                 505                 510         


Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Val Glu 
        515                 520                 525             


Leu Leu Gln Phe Gln Val Ser Ala Arg Asp Ala Gly Val Pro Pro Leu 
    530                 535                 540                 


Gly Ser Asn Val Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp Asn 
545                 550                 555                 560 


Ala Pro Ala Leu Leu Val Pro Arg Val Gly Gly Thr Gly Gly Ala Val 
                565                 570                 575     


Ser Glu Leu Val Pro Arg Ser Val Gly Ala Gly His Val Val Ala Lys 
            580                 585                 590         


Val Arg Ala Val Asp Pro Asp Ser Gly Tyr Asn Ala Trp Leu Ser Tyr 
        595                 600                 605             


Glu Leu Gln Pro Ala Pro Gly Ser Ala Arg Ile Pro Phe Arg Val Gly 
    610                 615                 620                 


Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Ser Leu Asp Glu Thr Glu 
625                 630                 635                 640 


Ala Pro Arg His Arg Leu Leu Val Leu Val Lys Asp His Gly Glu Pro 
                645                 650                 655     


Pro Leu Thr Ala Thr Ala Thr Val Leu Val Ser Leu Val Glu Ser Gly 
            660                 665                 670         


Gln Ala Pro Lys Ala Ser Ser Arg Ala Ser Ala Gly Ala Val Gly Pro 
        675                 680                 685             


Glu Ala Ala Leu Val Asp Val Asn Val Tyr Leu Ile Ile Ala Ile Cys 
    690                 695                 700                 


Ala Val Ser Ser Leu Leu Val Leu Thr Leu Leu Leu Tyr Thr Ala Leu 
705                 710                 715                 720 


Arg Cys Ser Ala Gln Pro Thr Glu Ala Val Cys Thr Arg Gly Lys Pro 
                725                 730                 735     


Thr Leu Leu Cys Ser Ser Ala Val Gly Ser Trp Ser Tyr Ser Gln Gln 
            740                 745                 750         


Arg Arg Gln Arg Val Cys Ser Gly Glu Ala Pro Pro Lys Thr Asp Leu 
        755                 760                 765             


Met Ala Phe Ser Pro Ser Leu Pro Gln Gly Pro Thr Ser Thr Asp Asn 
    770                 775                 780                 


Pro Arg Gln Pro Asn Pro Asp Trp Arg Tyr Ser Ala Ser Leu Arg Ala 
785                 790                 795                 800 


Gly Met His Ser Ser Val His Leu Glu Glu Ala Gly Ile Leu Arg Ala 
                805                 810                 815     


Gly Pro Gly Gly Pro Asp Gln Gln Trp Pro Thr Val Ser Ser Ala Thr 
            820                 825                 830         


Pro Glu Pro Glu Ala Gly Glu Val Ser Pro Pro Val Gly Ala Gly Val 
        835                 840                 845             


Asn Ser Asn Ser Trp Thr Phe Lys Tyr Gly Pro Gly Asn Pro Lys Gln 
    850                 855                 860                 


Ser Gly Pro Gly Glu Leu Pro Asp Lys Phe Ile Ile Pro Gly Ser Pro 
865                 870                 875                 880 


Ala Ile Ile Ser Ile Arg Gln Glu Pro Thr Asn Ser Gln Ile Asp Lys 
                885                 890                 895     


Ser Asp Phe Ile Thr Phe Gly Lys Lys Glu Glu Thr Lys Lys Lys Lys 
            900                 905                 910         


Lys Lys Lys Lys Gly Asn Lys Thr Gln Glu Lys Lys Glu Lys Gly Asn 
        915                 920                 925             


Ser Thr Thr Asp Asn Ser Asp Gln 
    930                 935     

<210>  227
<211>  2451
<212>  DNA
<213>  Homo sapiens

<400>  227
atggtatatt cccggagagg aagtctggga tcccggctcc tgctgctctg gcttctcctt     60

gcctactgga aggcagggag cggccagctc cactactcga tcccggagga agccaaacac    120

ggaaccttcg ttggccgcat cgcgcaggac ctagggctgg agctggcgga gctggtgccg    180

cgcctgttcc gggtggcgtc caagggccgc ggggaccttc tggaggtaaa tctgcagaat    240

ggcattttgt ttgtgaattc tcggatcgac cgggaggagc tgtgccggcg gagggcggag    300

tgcagcatcc acctggaggt gatcgtggac aggccgctgc aggttttcca tgtggaggtg    360

gcagtgaagg acatcaatga caatccgccc aggttctcca gacaagaaca aagattattc    420

attttagagt caagaatgcc agattcgcgg tttccgctag agggcgcgtc ggatttggat    480

attggagcaa atgcacaatt gagatacagg ttaaatccaa acgaatattt tgacttagat    540

gttaaaacaa atgaagaaga aacgaacttt ttagagctgg ttttgaggaa atccttagat    600

agagaagaaa cacaagaaca ccgtttatta gtgattgcaa ctgatggagg aaaacccgaa    660

ctaacaggta cagttcagtt gttgatcaat gtattggatg ctaatgataa cgccccagaa    720

tttgataaat ccatttataa tgtcagattg ttggaaaatg caccaagtgg gacattagtt    780

attaaactga acgcctcaga tgcagatgag ggcatcaata aggaaatagt gtatttcttt    840

agtaatcttg ttcttgacga tgtaaagtcc aaatttataa ttaattctaa tactggtgaa    900

ataaaagtta acggggaact ggattatgaa gactataact catatgaaat taatattgat    960

gccatggata aaagtacatt cccattatca ggacactgta aagtagtagt gaaactcctg   1020

gatgtgaatg ataatacccc agagatggcc ataaccaccc ttttcctgcc tgtcaaagag   1080

gacgctccac tcagcacggt cattgctctg atcagcgtgt ctgaccgtga ctcaggtgcc   1140

aacgggcagg tgacctgctc cctaatgccc cacgttccct tcaagctggt gtccaccttc   1200

aagaattact actcgttggt gctggacagc gccctggacc gcgagagcgt gtcggtctat   1260

gagctggtgg tgaccgcgcg ggacgggggc tcgccttcgc tgtgggccac cgccagcgtg   1320

tctgtggaag tggccgacgt gaacgacaac gctccggcgt tcgcgcagcc ccagtatacc   1380

gtgttcgtga aggagaacaa cccgccaggc tgccacatct tcacggtgtc tgcacgggac   1440

gcggacgcgc aggagaacgc cctggtgtcc tactcgctgg tggagcggcg ggtgggcgag   1500

cgcccgctgt cgagttacgt ttcggtgcac gcggagagcg gcaaggtgta cgcgctgcag   1560

ccgctggacc acgaggaagt ggagctgctg cagttccagg tgagcgcgcg cgacgcgggc   1620

gtgccgcctc tgggcagcaa cgtgacgctg caggtgttcg tgctggacga gaacgacaac   1680

gcgccggcgc tgctggtgcc tcgagtgggt ggcaccggcg gcgcagtgag cgagctggtg   1740

ccgaggtcag tgggtgcggg ccacgtggtg gcgaaggtgc gcgcagtgga ccctgattcg   1800

ggctacaacg cttggctttc gtatgagctg cagccagcgc ctggcagtgc gcgcatcccg   1860

ttccgcgtgg ggctgtacac aggcgagatc agcacaacac gctctctgga tgagaccgaa   1920

gcaccgcgcc accgccttct ggtgctggtg aaggaccatg gagagccccc gctgacagcc   1980

acagccacag tgctggtgtc gctggtggaa agtggccagg cgccgaaggc ctcatcgcgg   2040

gcgtcggcgg gcgctgtggg tcccgaggct gccctggtgg atgtcaacgt gtacctgatc   2100

atcgccatct gtgcggtgtc cagcctgctg gtgctcacgc tgctgctgta caccgcgctg   2160

cggtgctcgg cgcagcccac cgaggccgtg tgcacacggg gcaagcccac tctgttgtgc   2220

tccagcgcgg tggggagctg gtcgtactcg cagcagagga gacagagggt gtgctctggg   2280

gaagctccac ccaaaacaga cctcatggcc ttcagtccaa gccttcctca gggtcccacc   2340

tctacagaca acgtgagttt tctaatatta acatccatct ttccctccca attttcaaat   2400

attaaatgtc acattcaccc actttttttg tatttaaaaa ttatgtctta g            2451


<210>  228
<211>  816
<212>  PRT
<213>  Homo sapiens

<400>  228


Met Val Tyr Ser Arg Arg Gly Ser Leu Gly Ser Arg Leu Leu Leu Leu 
1               5                   10                  15      


Trp Leu Leu Leu Ala Tyr Trp Lys Ala Gly Ser Gly Gln Leu His Tyr 
            20                  25                  30          


Ser Ile Pro Glu Glu Ala Lys His Gly Thr Phe Val Gly Arg Ile Ala 
        35                  40                  45              


Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Pro Arg Leu Phe Arg 
    50                  55                  60                  


Val Ala Ser Lys Gly Arg Gly Asp Leu Leu Glu Val Asn Leu Gln Asn 
65                  70                  75                  80  


Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys Arg 
                85                  90                  95      


Arg Arg Ala Glu Cys Ser Ile His Leu Glu Val Ile Val Asp Arg Pro 
            100                 105                 110         


Leu Gln Val Phe His Val Glu Val Ala Val Lys Asp Ile Asn Asp Asn 
        115                 120                 125             


Pro Pro Arg Phe Ser Arg Gln Glu Gln Arg Leu Phe Ile Leu Glu Ser 
    130                 135                 140                 


Arg Met Pro Asp Ser Arg Phe Pro Leu Glu Gly Ala Ser Asp Leu Asp 
145                 150                 155                 160 


Ile Gly Ala Asn Ala Gln Leu Arg Tyr Arg Leu Asn Pro Asn Glu Tyr 
                165                 170                 175     


Phe Asp Leu Asp Val Lys Thr Asn Glu Glu Glu Thr Asn Phe Leu Glu 
            180                 185                 190         


Leu Val Leu Arg Lys Ser Leu Asp Arg Glu Glu Thr Gln Glu His Arg 
        195                 200                 205             


Leu Leu Val Ile Ala Thr Asp Gly Gly Lys Pro Glu Leu Thr Gly Thr 
    210                 215                 220                 


Val Gln Leu Leu Ile Asn Val Leu Asp Ala Asn Asp Asn Ala Pro Glu 
225                 230                 235                 240 


Phe Asp Lys Ser Ile Tyr Asn Val Arg Leu Leu Glu Asn Ala Pro Ser 
                245                 250                 255     


Gly Thr Leu Val Ile Lys Leu Asn Ala Ser Asp Ala Asp Glu Gly Ile 
            260                 265                 270         


Asn Lys Glu Ile Val Tyr Phe Phe Ser Asn Leu Val Leu Asp Asp Val 
        275                 280                 285             


Lys Ser Lys Phe Ile Ile Asn Ser Asn Thr Gly Glu Ile Lys Val Asn 
    290                 295                 300                 


Gly Glu Leu Asp Tyr Glu Asp Tyr Asn Ser Tyr Glu Ile Asn Ile Asp 
305                 310                 315                 320 


Ala Met Asp Lys Ser Thr Phe Pro Leu Ser Gly His Cys Lys Val Val 
                325                 330                 335     


Val Lys Leu Leu Asp Val Asn Asp Asn Thr Pro Glu Met Ala Ile Thr 
            340                 345                 350         


Thr Leu Phe Leu Pro Val Lys Glu Asp Ala Pro Leu Ser Thr Val Ile 
        355                 360                 365             


Ala Leu Ile Ser Val Ser Asp Arg Asp Ser Gly Ala Asn Gly Gln Val 
    370                 375                 380                 


Thr Cys Ser Leu Met Pro His Val Pro Phe Lys Leu Val Ser Thr Phe 
385                 390                 395                 400 


Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu Ser 
                405                 410                 415     


Val Ser Val Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser Pro 
            420                 425                 430         


Ser Leu Trp Ala Thr Ala Ser Val Ser Val Glu Val Ala Asp Val Asn 
        435                 440                 445             


Asp Asn Ala Pro Ala Phe Ala Gln Pro Gln Tyr Thr Val Phe Val Lys 
    450                 455                 460                 


Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Arg Asp 
465                 470                 475                 480 


Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu Arg 
                485                 490                 495     


Arg Val Gly Glu Arg Pro Leu Ser Ser Tyr Val Ser Val His Ala Glu 
            500                 505                 510         


Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Val Glu 
        515                 520                 525             


Leu Leu Gln Phe Gln Val Ser Ala Arg Asp Ala Gly Val Pro Pro Leu 
    530                 535                 540                 


Gly Ser Asn Val Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp Asn 
545                 550                 555                 560 


Ala Pro Ala Leu Leu Val Pro Arg Val Gly Gly Thr Gly Gly Ala Val 
                565                 570                 575     


Ser Glu Leu Val Pro Arg Ser Val Gly Ala Gly His Val Val Ala Lys 
            580                 585                 590         


Val Arg Ala Val Asp Pro Asp Ser Gly Tyr Asn Ala Trp Leu Ser Tyr 
        595                 600                 605             


Glu Leu Gln Pro Ala Pro Gly Ser Ala Arg Ile Pro Phe Arg Val Gly 
    610                 615                 620                 


Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Ser Leu Asp Glu Thr Glu 
625                 630                 635                 640 


Ala Pro Arg His Arg Leu Leu Val Leu Val Lys Asp His Gly Glu Pro 
                645                 650                 655     


Pro Leu Thr Ala Thr Ala Thr Val Leu Val Ser Leu Val Glu Ser Gly 
            660                 665                 670         


Gln Ala Pro Lys Ala Ser Ser Arg Ala Ser Ala Gly Ala Val Gly Pro 
        675                 680                 685             


Glu Ala Ala Leu Val Asp Val Asn Val Tyr Leu Ile Ile Ala Ile Cys 
    690                 695                 700                 


Ala Val Ser Ser Leu Leu Val Leu Thr Leu Leu Leu Tyr Thr Ala Leu 
705                 710                 715                 720 


Arg Cys Ser Ala Gln Pro Thr Glu Ala Val Cys Thr Arg Gly Lys Pro 
                725                 730                 735     


Thr Leu Leu Cys Ser Ser Ala Val Gly Ser Trp Ser Tyr Ser Gln Gln 
            740                 745                 750         


Arg Arg Gln Arg Val Cys Ser Gly Glu Ala Pro Pro Lys Thr Asp Leu 
        755                 760                 765             


Met Ala Phe Ser Pro Ser Leu Pro Gln Gly Pro Thr Ser Thr Asp Asn 
    770                 775                 780                 


Val Ser Phe Leu Ile Leu Thr Ser Ile Phe Pro Ser Gln Phe Ser Asn 
785                 790                 795                 800 


Ile Lys Cys His Ile His Pro Leu Phe Leu Tyr Leu Lys Ile Met Ser 
                805                 810                 815     

<210>  229
<211>  5287
<212>  DNA
<213>  Homo sapiens

<400>  229
atggaaataa aaccagaggt atttgacatg gtgtttaccc cggaggatag attgggaaag     60

caatgtctgc tcctcccgct tctgctcctc gcagcctgga aggtggggag cggccagctc    120

cactactccg tacccgagga ggccaaacac ggcaccttcg tgggccggat cgcgcaggac    180

ctggggctgg agctggcgga gctggtgccg cgcctgttca ggatggcctc caaagaccgc    240

gaggaccttc tggaggtaaa tctgcagaat ggcattttgt ttgtgaattc tcggatcgac    300

cgcgaggagc tgtgcgggcg gagcgcggag tgcagcatcc acctggaggt gatcgtggac    360

aggccgctgc aggttttcca tgtggacgtg gaggtgaggg acattaacga caacccgccc    420

ttgttcccgg tagaggaaca aagagtgctg atttacgaat ctaggctgcc agattctgtg    480

tttccactgg agggcgcgtc cgatgcagat gttggctcaa attccatctt aacctataaa    540

ctcagttcta gcgaatactt cgggctagat gtgaaaataa acagtgatga caataaacaa    600

attgggctct tattaaagaa atccttggac agagaggaag ctcctgcaca caacttattc    660

ctgacagcca cagatggggg caaacctgag ctcacaggca ctgttcagct gctggtcaca    720

gtgctggatg tgaatgataa tgctcccact ttcgaacagt ctgaatacga agtaagaata    780

ttcgaaaatg cagacaacgg aacaacagtt atcagactga atgcttctga tcgggatgaa    840

ggagcgaatg gggcaatttc atattctttt aatagccttg ttgcagccat ggttattgac    900

cactttagca tagatcgaaa tacgggagaa atagtgattc ggggtaattt ggattttgaa    960

caagaaaact tatacaaaat cctcattgac gccacggaca aaggccatcc tcccatggcg   1020

ggtcattgca ccgttttagt gagaattttg gataaaaatg ataacgtccc tgagatagca   1080

ctgacttcct tatccttgcc tgtacgtgaa gacgctcaat ttggtactgt catcgcccta   1140

attagcgtga acgacctcga ttcaggtgcc aacgggcagg tgaactgctc gctgacgcct   1200

cacgtccctt tcaagctggt gtccaccttc aagaattact actcgttggt gctggacagt   1260

gccctggacc gcgagagcgt gtcggcctat gagttggtgg taaccgcgcg ggacgggggc   1320

tcgccttcgc tgtgggccac cgccagcttg tctgtggagg tggccgacat gaatgacaat   1380

gctccggcgt tcgcgcagcc cgagtacaca gtgttcgtga aggagaacaa cccgccgggc   1440

tgccacatct tcacggtgtc tgcgcgagac gcggacgcgc aggagaacgc gctggtgtcc   1500

tactcgctgg tggagcggcg ggtgggcgag cgcgcgttgt cgagctacat ttcggtgcac   1560

gcggagagcg gcaaggtgta cgcgctgcag ccgctggacc acgaggagct agagctgctg   1620

cagtttcagg tgagcgcgcg cgacgcgggc gtgccgcctc tgggcagcaa cgtgacgctg   1680

caggtgttcg tgctggacga gaacgacaac gcgccggcgc tgctggcgcc tcgggtgggt   1740

ggtactggtg gtgcagtgag cgagctggtg ccgcggtcac tgggtgcagg ccaagtggtg   1800

gcgaaggtgc gcgcagttga cgccgactca ggctacaacg cgtggctttc gtatgagctg   1860

cagcccccgg caagcagcgc tcgcttcccg tttcgcgtgg ggctgtacac gggcgagatc   1920

agcaccactc gtgtcctgga cgaagcggac tctccgcgcc accggctgct ggtgctggtg   1980

aaagaccacg gtgagccggc gctgacagcg acggccacgg ttctggtgtc gctggtggag   2040

agtggccagg ctccaaaggc gtcatcacgg gcgtcggtgg gcgccgcggg cccagaggcg   2100

gcgctggtgg atgtcaacgt gtacctgatc atcgccatct gcgcggtatc cagcctgctg   2160

gtcctcacgc tactgctgta cacagcgctg cggtgctcgg cgccacccac cgagggcgcg   2220

tgcacggcgg acaagcccac gctggtgtgc tccagcgcag tggggagctg gtcgtactcg   2280

cagcagaggc ggcagagggt gtgctccggg gagggcccac ccaagatgga tctcatggcc   2340

tttagcccca gcctttcacc ttgtcctatt atgatgggta aggcggagaa tcaggattta   2400

aatgaagatc atgatgccaa accacgacag cccaaccctg actggcgtta ctctgcctcc   2460

ctgagagcag gcatgcacag ctctgtgcac ctagaggagg ctggcattct acgggctggt   2520

ccaggagggc ctgatcagca gtggccaaca gtatccagtg caacaccaga accagaggca   2580

ggagaagtgt cccctccagt cggtgcgggt gtcaacagca acagctggac ctttaaatac   2640

ggaccaggca accccaaaca atccggtccc ggtgagttgc ccgacaaatt cattatccca   2700

ggatctcctg caatcatctc catccggcag gagcctacta acagccaaat tgacaaaagt   2760

gacttcataa ccttcggcaa aaaggaggag accaagaaaa agaagaaaaa gaagaagggt   2820

aacaagaccc aggagaaaaa agagaaaggg aacagcacga ctgacaacag tgaccagtga   2880

ggtcctcaaa tggaaacaag ccacttagcc agtttttgta ataatggcaa atctctccca   2940

tgtagcaatt ccctgctcct ttttcctatc tacatgagcc ctcttagaga cctcagaaat   3000

ctgcagaaag ttccctgtgt ctgtctagaa cgcatttaac aggttttgtc gtaaaagctt   3060

tactaagtct ggtgttaact ctttctctcc actctggctt gttttcagaa cctaaaaagc   3120

agacccaagt ttcctttctc ctccgccgca aaggagaggc ttcccagccc cgccagtgag   3180

aggttggact ctctgccctg tgctccgggg atcctgtctt gatgacactt gcagggcagg   3240

ctgaaaagtt ttgagattga gcagcttggg agtttgtggc cactgggtat gtgtggctac   3300

cgcgggtatg cgagtgccag atattggctg agacgagcca gcttagacta attggtacaa   3360

ggaaggcaag aaaacaaaga caaataaaca gcggaagtta tcagtatgga ggggaagtgt   3420

aaacttaaag ggaccagact ttctaaatct tacaactcaa gaggtggcag ccaccctcta   3480

ggagacaaaa ctacccccac tgacaaggct ttaggagacc ctaaagtctg ttggctgtga   3540

cgtcattata cctaaaatct gcatcatacc tgcaagccaa cagttcagtg ttttaacaga   3600

gaaccaccct gggaaacaga agcagatctg atgtgtttcc tatacatgtc ctgtgctcac   3660

tttattaaaa attcttttgc acacaatgtt tatgaaaagg ccagatcctt ttccaatact   3720

tatgcaaaag caaaagaaaa ccccgacacc tcacctttcg ctgtttgttg tttcatagat   3780

ttatttaaaa aaagagaaag tctatagcta taaatcttta aagagaaata tgaatacaat   3840

tcccctaaac tctcctcaaa agagaattca gtctacagcc atttaaatga tcattgctgc   3900

tacagaagtg ctttaagaga attgcctgaa acatctgtat tatatcggcc acctgccaat   3960

cacagcttta ctctttcagg tcactctggg gctgcctctt gcatgtatta ctaaataaaa   4020

tgatctctct ttctctctct ctctctcttt tctaagaaac aattatgtgc actttgatac   4080

acaaccttct ctaaccaact atatatcaag acccaaaaat tgaagaaaaa tattgttttc   4140

tcatacagtg agcagatttt tcaatctact aattctgtga cttgtcttgg tgtgctagcc   4200

tacaccttct ctttggttta gttttccttt tctataacac tctgaattgc taatcttact   4260

aacacctatg atgttacctg aaatcaatct cccatatgta tgctgtatgc tatgctaaga   4320

ctcctgaaat atacttactc tgtgcttgtg tatgtgaatg ttaatgcaac tattacctag   4380

agtgaacttt aagctttatt gttgaatgta attccattat atttcctttt gtacacctgt   4440

gaaaaagtgg agtagtgttt ttttaaccat tgttaatcag cttttgtgta tgaaagacac   4500

agtaaaattt ctttcttaaa tcaagatact ggtgattcaa ggaattttat ttatggtcca   4560

gccaagagcc atctcgtgcc aagacttctg ctggcaaggg aatggataaa gctgttttgt   4620

tctagtaaca attttggaat gaatactgac aatattccat gagggtgtgc aagcacaaat   4680

tttaccaatc tgacctcttt gaagttgcag aatgctttga aattctaatg gtatctgaaa   4740

tatcagctca tagaaagtaa caaaatttgc tgtcacctta aataagacat tttaattttg   4800

ttataatgta caatttagaa gtttgattaa ttatattatc tatttaggca ttaatataaa   4860

agaggtagga gtctgttatt taaaaaaagc attaaattta aaaaaaaact gtcttgtcta   4920

cttttagctt cattctccca tattttgaag ggtgtgtaac ttcagctctg caggattgca   4980

tggggtaaaa cttgttacca acacatgtga accattgcta cattgtaggt tgtgatcatt   5040

ttgccccact gaagcccatg tatctgacct tacgtgcctt ttgaactagg agaatcgggc   5100

taatttatta atgatgataa ttataatgta tctgtacagc actttttaca tttgcgaagt   5160

gctttccaat ccatgttagt tactagttat tacagctgta aggataaaac acgtcatgtg   5220

gattcatttt gaattggtgc tattggtatt tcctctgtta ttgctaataa atgaaaatgg   5280

tggtatg                                                             5287


<210>  230
<211>  950
<212>  PRT
<213>  Homo sapiens

<400>  230


Met Val Phe Thr Pro Glu Asp Arg Leu Gly Lys Gln Cys Leu Leu Leu 
1               5                   10                  15      


Pro Leu Leu Leu Leu Ala Ala Trp Lys Val Gly Ser Gly Gln Leu His 
            20                  25                  30          


Tyr Ser Val Pro Glu Glu Ala Lys His Gly Thr Phe Val Gly Arg Ile 
        35                  40                  45              


Ala Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Pro Arg Leu Phe 
    50                  55                  60                  


Arg Met Ala Ser Lys Asp Arg Glu Asp Leu Leu Glu Val Asn Leu Gln 
65                  70                  75                  80  


Asn Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Gly Arg Ser Ala Glu Cys Ser Ile His Leu Glu Val Ile Val Asp Arg 
            100                 105                 110         


Pro Leu Gln Val Phe His Val Asp Val Glu Val Arg Asp Ile Asn Asp 
        115                 120                 125             


Asn Pro Pro Leu Phe Pro Val Glu Glu Gln Arg Val Leu Ile Tyr Glu 
    130                 135                 140                 


Ser Arg Leu Pro Asp Ser Val Phe Pro Leu Glu Gly Ala Ser Asp Ala 
145                 150                 155                 160 


Asp Val Gly Ser Asn Ser Ile Leu Thr Tyr Lys Leu Ser Ser Ser Glu 
                165                 170                 175     


Tyr Phe Gly Leu Asp Val Lys Ile Asn Ser Asp Asp Asn Lys Gln Ile 
            180                 185                 190         


Gly Leu Leu Leu Lys Lys Ser Leu Asp Arg Glu Glu Ala Pro Ala His 
        195                 200                 205             


Asn Leu Phe Leu Thr Ala Thr Asp Gly Gly Lys Pro Glu Leu Thr Gly 
    210                 215                 220                 


Thr Val Gln Leu Leu Val Thr Val Leu Asp Val Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Thr Phe Glu Gln Ser Glu Tyr Glu Val Arg Ile Phe Glu Asn Ala Asp 
                245                 250                 255     


Asn Gly Thr Thr Val Ile Arg Leu Asn Ala Ser Asp Arg Asp Glu Gly 
            260                 265                 270         


Ala Asn Gly Ala Ile Ser Tyr Ser Phe Asn Ser Leu Val Ala Ala Met 
        275                 280                 285             


Val Ile Asp His Phe Ser Ile Asp Arg Asn Thr Gly Glu Ile Val Ile 
    290                 295                 300                 


Arg Gly Asn Leu Asp Phe Glu Gln Glu Asn Leu Tyr Lys Ile Leu Ile 
305                 310                 315                 320 


Asp Ala Thr Asp Lys Gly His Pro Pro Met Ala Gly His Cys Thr Val 
                325                 330                 335     


Leu Val Arg Ile Leu Asp Lys Asn Asp Asn Val Pro Glu Ile Ala Leu 
            340                 345                 350         


Thr Ser Leu Ser Leu Pro Val Arg Glu Asp Ala Gln Phe Gly Thr Val 
        355                 360                 365             


Ile Ala Leu Ile Ser Val Asn Asp Leu Asp Ser Gly Ala Asn Gly Gln 
    370                 375                 380                 


Val Asn Cys Ser Leu Thr Pro His Val Pro Phe Lys Leu Val Ser Thr 
385                 390                 395                 400 


Phe Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu 
                405                 410                 415     


Ser Val Ser Ala Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser 
            420                 425                 430         


Pro Ser Leu Trp Ala Thr Ala Ser Leu Ser Val Glu Val Ala Asp Met 
        435                 440                 445             


Asn Asp Asn Ala Pro Ala Phe Ala Gln Pro Glu Tyr Thr Val Phe Val 
    450                 455                 460                 


Lys Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Arg 
465                 470                 475                 480 


Asp Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu 
                485                 490                 495     


Arg Arg Val Gly Glu Arg Ala Leu Ser Ser Tyr Ile Ser Val His Ala 
            500                 505                 510         


Glu Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu 
        515                 520                 525             


Glu Leu Leu Gln Phe Gln Val Ser Ala Arg Asp Ala Gly Val Pro Pro 
    530                 535                 540                 


Leu Gly Ser Asn Val Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp 
545                 550                 555                 560 


Asn Ala Pro Ala Leu Leu Ala Pro Arg Val Gly Gly Thr Gly Gly Ala 
                565                 570                 575     


Val Ser Glu Leu Val Pro Arg Ser Leu Gly Ala Gly Gln Val Val Ala 
            580                 585                 590         


Lys Val Arg Ala Val Asp Ala Asp Ser Gly Tyr Asn Ala Trp Leu Ser 
        595                 600                 605             


Tyr Glu Leu Gln Pro Pro Ala Ser Ser Ala Arg Phe Pro Phe Arg Val 
    610                 615                 620                 


Gly Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Val Leu Asp Glu Ala 
625                 630                 635                 640 


Asp Ser Pro Arg His Arg Leu Leu Val Leu Val Lys Asp His Gly Glu 
                645                 650                 655     


Pro Ala Leu Thr Ala Thr Ala Thr Val Leu Val Ser Leu Val Glu Ser 
            660                 665                 670         


Gly Gln Ala Pro Lys Ala Ser Ser Arg Ala Ser Val Gly Ala Ala Gly 
        675                 680                 685             


Pro Glu Ala Ala Leu Val Asp Val Asn Val Tyr Leu Ile Ile Ala Ile 
    690                 695                 700                 


Cys Ala Val Ser Ser Leu Leu Val Leu Thr Leu Leu Leu Tyr Thr Ala 
705                 710                 715                 720 


Leu Arg Cys Ser Ala Pro Pro Thr Glu Gly Ala Cys Thr Ala Asp Lys 
                725                 730                 735     


Pro Thr Leu Val Cys Ser Ser Ala Val Gly Ser Trp Ser Tyr Ser Gln 
            740                 745                 750         


Gln Arg Arg Gln Arg Val Cys Ser Gly Glu Gly Pro Pro Lys Met Asp 
        755                 760                 765             


Leu Met Ala Phe Ser Pro Ser Leu Ser Pro Cys Pro Ile Met Met Gly 
    770                 775                 780                 


Lys Ala Glu Asn Gln Asp Leu Asn Glu Asp His Asp Ala Lys Pro Arg 
785                 790                 795                 800 


Gln Pro Asn Pro Asp Trp Arg Tyr Ser Ala Ser Leu Arg Ala Gly Met 
                805                 810                 815     


His Ser Ser Val His Leu Glu Glu Ala Gly Ile Leu Arg Ala Gly Pro 
            820                 825                 830         


Gly Gly Pro Asp Gln Gln Trp Pro Thr Val Ser Ser Ala Thr Pro Glu 
        835                 840                 845             


Pro Glu Ala Gly Glu Val Ser Pro Pro Val Gly Ala Gly Val Asn Ser 
    850                 855                 860                 


Asn Ser Trp Thr Phe Lys Tyr Gly Pro Gly Asn Pro Lys Gln Ser Gly 
865                 870                 875                 880 


Pro Gly Glu Leu Pro Asp Lys Phe Ile Ile Pro Gly Ser Pro Ala Ile 
                885                 890                 895     


Ile Ser Ile Arg Gln Glu Pro Thr Asn Ser Gln Ile Asp Lys Ser Asp 
            900                 905                 910         


Phe Ile Thr Phe Gly Lys Lys Glu Glu Thr Lys Lys Lys Lys Lys Lys 
        915                 920                 925             


Lys Lys Gly Asn Lys Thr Gln Glu Lys Lys Glu Lys Gly Asn Ser Thr 
    930                 935                 940                 


Thr Asp Asn Ser Asp Gln 
945                 950 

<210>  231
<211>  2439
<212>  DNA
<213>  Homo sapiens

<400>  231
atggaaataa aaccagaggt atttgacatg gtgtttaccc cggaggatag attgggaaag     60

caatgtctgc tcctcccgct tctgctcctc gcagcctgga aggtggggag cggccagctc    120

cactactccg tacccgagga ggccaaacac ggcaccttcg tgggccggat cgcgcaggac    180

ctggggctgg agctggcgga gctggtgccg cgcctgttca ggatggcctc caaagaccgc    240

gaggaccttc tggaggtaaa tctgcagaat ggcattttgt ttgtgaattc tcggatcgac    300

cgcgaggagc tgtgcgggcg gagcgcggag tgcagcatcc acctggaggt gatcgtggac    360

aggccgctgc aggttttcca tgtggacgtg gaggtgaggg acattaacga caacccgccc    420

ttgttcccgg tagaggaaca aagagtgctg atttacgaat ctaggctgcc agattctgtg    480

tttccactgg agggcgcgtc cgatgcagat gttggctcaa attccatctt aacctataaa    540

ctcagttcta gcgaatactt cgggctagat gtgaaaataa acagtgatga caataaacaa    600

attgggctct tattaaagaa atccttggac agagaggaag ctcctgcaca caacttattc    660

ctgacagcca cagatggggg caaacctgag ctcacaggca ctgttcagct gctggtcaca    720

gtgctggatg tgaatgataa tgctcccact ttcgaacagt ctgaatacga agtaagaata    780

ttcgaaaatg cagacaacgg aacaacagtt atcagactga atgcttctga tcgggatgaa    840

ggagcgaatg gggcaatttc atattctttt aatagccttg ttgcagccat ggttattgac    900

cactttagca tagatcgaaa tacgggagaa atagtgattc ggggtaattt ggattttgaa    960

caagaaaact tatacaaaat cctcattgac gccacggaca aaggccatcc tcccatggcg   1020

ggtcattgca ccgttttagt gagaattttg gataaaaatg ataacgtccc tgagatagca   1080

ctgacttcct tatccttgcc tgtacgtgaa gacgctcaat ttggtactgt catcgcccta   1140

attagcgtga acgacctcga ttcaggtgcc aacgggcagg tgaactgctc gctgacgcct   1200

cacgtccctt tcaagctggt gtccaccttc aagaattact actcgttggt gctggacagt   1260

gccctggacc gcgagagcgt gtcggcctat gagttggtgg taaccgcgcg ggacgggggc   1320

tcgccttcgc tgtgggccac cgccagcttg tctgtggagg tggccgacat gaatgacaat   1380

gctccggcgt tcgcgcagcc cgagtacaca gtgttcgtga aggagaacaa cccgccgggc   1440

tgccacatct tcacggtgtc tgcgcgagac gcggacgcgc aggagaacgc gctggtgtcc   1500

tactcgctgg tggagcggcg ggtgggcgag cgcgcgttgt cgagctacat ttcggtgcac   1560

gcggagagcg gcaaggtgta cgcgctgcag ccgctggacc acgaggagct agagctgctg   1620

cagtttcagg tgagcgcgcg cgacgcgggc gtgccgcctc tgggcagcaa cgtgacgctg   1680

caggtgttcg tgctggacga gaacgacaac gcgccggcgc tgctggcgcc tcgggtgggt   1740

ggtactggtg gtgcagtgag cgagctggtg ccgcggtcac tgggtgcagg ccaagtggtg   1800

gcgaaggtgc gcgcagttga cgccgactca ggctacaacg cgtggctttc gtatgagctg   1860

cagcccccgg caagcagcgc tcgcttcccg tttcgcgtgg ggctgtacac gggcgagatc   1920

agcaccactc gtgtcctgga cgaagcggac tctccgcgcc accggctgct ggtgctggtg   1980

aaagaccacg gtgagccggc gctgacagcg acggccacgg ttctggtgtc gctggtggag   2040

agtggccagg ctccaaaggc gtcatcacgg gcgtcggtgg gcgccgcggg cccagaggcg   2100

gcgctggtgg atgtcaacgt gtacctgatc atcgccatct gcgcggtatc cagcctgctg   2160

gtcctcacgc tactgctgta cacagcgctg cggtgctcgg cgccacccac cgagggcgcg   2220

tgcacggcgg acaagcccac gctggtgtgc tccagcgcag tggggagctg gtcgtactcg   2280

cagcagaggc ggcagagggt gtgctccggg gagggcccac ccaagatgga tctcatggcc   2340

tttagcccca gcctttcacc ttgtcctatt atgatgggta aggcggagaa tcaggattta   2400

aatgaagatc atgatgccaa agtaagtgaa ttttcataa                          2439


<210>  232
<211>  803
<212>  PRT
<213>  Homo sapiens

<400>  232


Met Val Phe Thr Pro Glu Asp Arg Leu Gly Lys Gln Cys Leu Leu Leu 
1               5                   10                  15      


Pro Leu Leu Leu Leu Ala Ala Trp Lys Val Gly Ser Gly Gln Leu His 
            20                  25                  30          


Tyr Ser Val Pro Glu Glu Ala Lys His Gly Thr Phe Val Gly Arg Ile 
        35                  40                  45              


Ala Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Pro Arg Leu Phe 
    50                  55                  60                  


Arg Met Ala Ser Lys Asp Arg Glu Asp Leu Leu Glu Val Asn Leu Gln 
65                  70                  75                  80  


Asn Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Gly Arg Ser Ala Glu Cys Ser Ile His Leu Glu Val Ile Val Asp Arg 
            100                 105                 110         


Pro Leu Gln Val Phe His Val Asp Val Glu Val Arg Asp Ile Asn Asp 
        115                 120                 125             


Asn Pro Pro Leu Phe Pro Val Glu Glu Gln Arg Val Leu Ile Tyr Glu 
    130                 135                 140                 


Ser Arg Leu Pro Asp Ser Val Phe Pro Leu Glu Gly Ala Ser Asp Ala 
145                 150                 155                 160 


Asp Val Gly Ser Asn Ser Ile Leu Thr Tyr Lys Leu Ser Ser Ser Glu 
                165                 170                 175     


Tyr Phe Gly Leu Asp Val Lys Ile Asn Ser Asp Asp Asn Lys Gln Ile 
            180                 185                 190         


Gly Leu Leu Leu Lys Lys Ser Leu Asp Arg Glu Glu Ala Pro Ala His 
        195                 200                 205             


Asn Leu Phe Leu Thr Ala Thr Asp Gly Gly Lys Pro Glu Leu Thr Gly 
    210                 215                 220                 


Thr Val Gln Leu Leu Val Thr Val Leu Asp Val Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Thr Phe Glu Gln Ser Glu Tyr Glu Val Arg Ile Phe Glu Asn Ala Asp 
                245                 250                 255     


Asn Gly Thr Thr Val Ile Arg Leu Asn Ala Ser Asp Arg Asp Glu Gly 
            260                 265                 270         


Ala Asn Gly Ala Ile Ser Tyr Ser Phe Asn Ser Leu Val Ala Ala Met 
        275                 280                 285             


Val Ile Asp His Phe Ser Ile Asp Arg Asn Thr Gly Glu Ile Val Ile 
    290                 295                 300                 


Arg Gly Asn Leu Asp Phe Glu Gln Glu Asn Leu Tyr Lys Ile Leu Ile 
305                 310                 315                 320 


Asp Ala Thr Asp Lys Gly His Pro Pro Met Ala Gly His Cys Thr Val 
                325                 330                 335     


Leu Val Arg Ile Leu Asp Lys Asn Asp Asn Val Pro Glu Ile Ala Leu 
            340                 345                 350         


Thr Ser Leu Ser Leu Pro Val Arg Glu Asp Ala Gln Phe Gly Thr Val 
        355                 360                 365             


Ile Ala Leu Ile Ser Val Asn Asp Leu Asp Ser Gly Ala Asn Gly Gln 
    370                 375                 380                 


Val Asn Cys Ser Leu Thr Pro His Val Pro Phe Lys Leu Val Ser Thr 
385                 390                 395                 400 


Phe Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu 
                405                 410                 415     


Ser Val Ser Ala Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser 
            420                 425                 430         


Pro Ser Leu Trp Ala Thr Ala Ser Leu Ser Val Glu Val Ala Asp Met 
        435                 440                 445             


Asn Asp Asn Ala Pro Ala Phe Ala Gln Pro Glu Tyr Thr Val Phe Val 
    450                 455                 460                 


Lys Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Arg 
465                 470                 475                 480 


Asp Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu 
                485                 490                 495     


Arg Arg Val Gly Glu Arg Ala Leu Ser Ser Tyr Ile Ser Val His Ala 
            500                 505                 510         


Glu Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu 
        515                 520                 525             


Glu Leu Leu Gln Phe Gln Val Ser Ala Arg Asp Ala Gly Val Pro Pro 
    530                 535                 540                 


Leu Gly Ser Asn Val Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp 
545                 550                 555                 560 


Asn Ala Pro Ala Leu Leu Ala Pro Arg Val Gly Gly Thr Gly Gly Ala 
                565                 570                 575     


Val Ser Glu Leu Val Pro Arg Ser Leu Gly Ala Gly Gln Val Val Ala 
            580                 585                 590         


Lys Val Arg Ala Val Asp Ala Asp Ser Gly Tyr Asn Ala Trp Leu Ser 
        595                 600                 605             


Tyr Glu Leu Gln Pro Pro Ala Ser Ser Ala Arg Phe Pro Phe Arg Val 
    610                 615                 620                 


Gly Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Val Leu Asp Glu Ala 
625                 630                 635                 640 


Asp Ser Pro Arg His Arg Leu Leu Val Leu Val Lys Asp His Gly Glu 
                645                 650                 655     


Pro Ala Leu Thr Ala Thr Ala Thr Val Leu Val Ser Leu Val Glu Ser 
            660                 665                 670         


Gly Gln Ala Pro Lys Ala Ser Ser Arg Ala Ser Val Gly Ala Ala Gly 
        675                 680                 685             


Pro Glu Ala Ala Leu Val Asp Val Asn Val Tyr Leu Ile Ile Ala Ile 
    690                 695                 700                 


Cys Ala Val Ser Ser Leu Leu Val Leu Thr Leu Leu Leu Tyr Thr Ala 
705                 710                 715                 720 


Leu Arg Cys Ser Ala Pro Pro Thr Glu Gly Ala Cys Thr Ala Asp Lys 
                725                 730                 735     


Pro Thr Leu Val Cys Ser Ser Ala Val Gly Ser Trp Ser Tyr Ser Gln 
            740                 745                 750         


Gln Arg Arg Gln Arg Val Cys Ser Gly Glu Gly Pro Pro Lys Met Asp 
        755                 760                 765             


Leu Met Ala Phe Ser Pro Ser Leu Ser Pro Cys Pro Ile Met Met Gly 
    770                 775                 780                 


Lys Ala Glu Asn Gln Asp Leu Asn Glu Asp His Asp Ala Lys Val Ser 
785                 790                 795                 800 


Glu Phe Ser 
            

<210>  233
<211>  4495
<212>  DNA
<213>  Homo sapiens

<400>  233
atggaaataa aaccagaggt atttgacatg gtgtttaccc cggaggatag attgggaaag     60

caatgtctgc tcctcccgct tctgctcctc gcagcctgga aggtggggag cggccagctc    120

cactactccg tacccgagga ggccaaacac ggcaccttcg tgggccggat cgcgcaggac    180

ctggggctgg agctggcgga gctggtgccg cgcctgttca ggatggcctc caaagaccgc    240

gaggaccttc tggaggtaaa tctgcagaat ggcattttgt ttgtgaattc tcggatcgac    300

cgcgaggagc tgtgcgggcg gagcgcggag tgcagcatcc acctggaggt gatcgtggac    360

aggccgctgc aggttttcca tgtggacgtg gaggtgaggg acattaacga caacccgccc    420

ttgttcccgg tagaggaaca aagagtgctg atttacgaat ctaggctgcc agattctgtg    480

tttccactgg agggcgcgtc cgatgcagat gttggctcaa attccatctt aacctataaa    540

ctcagttcta gcgaatactt cgggctagat gtgaaaataa acagtgatga caataaacaa    600

attgggctct tattaaagaa atccttggac agagaggaag ctcctgcaca caacttattc    660

ctgacagcca cagatggggg caaacctgag ctcacaggca ctgttcagct gctggtcaca    720

gtgctggatg tgaatgataa tgctcccact ttcgaacagt ctgaatacga agtaagaata    780

ttcgaaaatg cagacaacgg aacaacagtt atcagactga atgcttctga tcgggatgaa    840

ggagcgaatg gggcaatttc atattctttt aatagccttg ttgcagccat ggttattgac    900

cactttagca tagatcgaaa tacgggagaa atagtgattc ggggtaattt ggattttgaa    960

caagaaaact tatacaaaat cctcattgac gccacggaca aaggccatcc tcccatggcg   1020

ggtcattgca ccgttttagt gagaattttg gataaaaatg ataacgtccc tgagatagca   1080

ctgacttcct tatccttgcc tgtacgtgaa gacgctcaat ttggtactgt catcgcccta   1140

attagcgtga acgacctcga ttcaggtgcc aacgggcagg tgaactgctc gctgacgcct   1200

cacgtccctt tcaagctggt gtccaccttc aagaattact actcgttggt gctggacagt   1260

gccctggacc gcgagagcgt gtcggcctat gagttggtgg taaccgcgcg ggacgggggc   1320

tcgccttcgc tgtgggccac cgccagcttg tctgtggagg tggccgacat gaatgacaat   1380

gctccggcgt tcgcgcagcc cgagtacaca gtgttcgtga aggagaacaa cccgccgggc   1440

tgccacatct tcacggtgtc tgcgcgagac gcggacgcgc aggagaacgc gctggtgtcc   1500

tactcgctgg tggagcggcg ggtgggcgag cgcgcgttgt cgagctacat ttcggtgcac   1560

gcggagagcg gcaaggtgta cgcgctgcag ccgctggacc acgaggagct agagctgctg   1620

cagtttcagc cacgacagcc caaccctgac tggcgttact ctgcctccct gagagcaggc   1680

atgcacagct ctgtgcacct agaggaggct ggcattctac gggctggtcc aggagggcct   1740

gatcagcagt ggccaacagt atccagtgca acaccagaac cagaggcagg agaagtgtcc   1800

cctccagtcg gtgcgggtgt caacagcaac agctggacct ttaaatacgg accaggcaac   1860

cccaaacaat ccggtcccgg tgagttgccc gacaaattca ttatcccagg atctcctgca   1920

atcatctcca tccggcagga gcctactaac agccaaattg acaaaagtga cttcataacc   1980

ttcggcaaaa aggaggagac caagaaaaag aagaaaaaga agaagggtaa caagacccag   2040

gagaaaaaag agaaagggaa cagcacgact gacaacagtg accagtgagg tcctcaaatg   2100

gaaacaagcc acttagccag tttttgtaat aatggcaaat ctctcccatg tagcaattcc   2160

ctgctccttt ttcctatcta catgagccct cttagagacc tcagaaatct gcagaaagtt   2220

ccctgtgtct gtctagaacg catttaacag gttttgtcgt aaaagcttta ctaagtctgg   2280

tgttaactct ttctctccac tctggcttgt tttcagaacc taaaaagcag acccaagttt   2340

cctttctcct ccgccgcaaa ggagaggctt cccagccccg ccagtgagag gttggactct   2400

ctgccctgtg ctccggggat cctgtcttga tgacacttgc agggcaggct gaaaagtttt   2460

gagattgagc agcttgggag tttgtggcca ctgggtatgt gtggctaccg cgggtatgcg   2520

agtgccagat attggctgag acgagccagc ttagactaat tggtacaagg aaggcaagaa   2580

aacaaagaca aataaacagc ggaagttatc agtatggagg ggaagtgtaa acttaaaggg   2640

accagacttt ctaaatctta caactcaaga ggtggcagcc accctctagg agacaaaact   2700

acccccactg acaaggcttt aggagaccct aaagtctgtt ggctgtgacg tcattatacc   2760

taaaatctgc atcatacctg caagccaaca gttcagtgtt ttaacagaga accaccctgg   2820

gaaacagaag cagatctgat gtgtttccta tacatgtcct gtgctcactt tattaaaaat   2880

tcttttgcac acaatgttta tgaaaaggcc agatcctttt ccaatactta tgcaaaagca   2940

aaagaaaacc ccgacacctc acctttcgct gtttgttgtt tcatagattt atttaaaaaa   3000

agagaaagtc tatagctata aatctttaaa gagaaatatg aatacaattc ccctaaactc   3060

tcctcaaaag agaattcagt ctacagccat ttaaatgatc attgctgcta cagaagtgct   3120

ttaagagaat tgcctgaaac atctgtatta tatcggccac ctgccaatca cagctttact   3180

ctttcaggtc actctggggc tgcctcttgc atgtattact aaataaaatg atctctcttt   3240

ctctctctct ctctcttttc taagaaacaa ttatgtgcac tttgatacac aaccttctct   3300

aaccaactat atatcaagac ccaaaaattg aagaaaaata ttgttttctc atacagtgag   3360

cagatttttc aatctactaa ttctgtgact tgtcttggtg tgctagccta caccttctct   3420

ttggtttagt tttccttttc tataacactc tgaattgcta atcttactaa cacctatgat   3480

gttacctgaa atcaatctcc catatgtatg ctgtatgcta tgctaagact cctgaaatat   3540

acttactctg tgcttgtgta tgtgaatgtt aatgcaacta ttacctagag tgaactttaa   3600

gctttattgt tgaatgtaat tccattatat ttccttttgt acacctgtga aaaagtggag   3660

tagtgttttt ttaaccattg ttaatcagct tttgtgtatg aaagacacag taaaatttct   3720

ttcttaaatc aagatactgg tgattcaagg aattttattt atggtccagc caagagccat   3780

ctcgtgccaa gacttctgct ggcaagggaa tggataaagc tgttttgttc tagtaacaat   3840

tttggaatga atactgacaa tattccatga gggtgtgcaa gcacaaattt taccaatctg   3900

acctctttga agttgcagaa tgctttgaaa ttctaatggt atctgaaata tcagctcata   3960

gaaagtaaca aaatttgctg tcaccttaaa taagacattt taattttgtt ataatgtaca   4020

atttagaagt ttgattaatt atattatcta tttaggcatt aatataaaag aggtaggagt   4080

ctgttattta aaaaaagcat taaatttaaa aaaaaactgt cttgtctact tttagcttca   4140

ttctcccata ttttgaaggg tgtgtaactt cagctctgca ggattgcatg gggtaaaact   4200

tgttaccaac acatgtgaac cattgctaca ttgtaggttg tgatcatttt gccccactga   4260

agcccatgta tctgacctta cgtgcctttt gaactaggag aatcgggcta atttattaat   4320

gatgataatt ataatgtatc tgtacagcac tttttacatt tgcgaagtgc tttccaatcc   4380

atgttagtta ctagttatta cagctgtaag gataaaacac gtcatgtgga ttcattttga   4440

attggtgcta ttggtatttc ctctgttatt gctaataaat gaaaatggtg gtatg        4495


<210>  234
<211>  686
<212>  PRT
<213>  Homo sapiens

<400>  234


Met Val Phe Thr Pro Glu Asp Arg Leu Gly Lys Gln Cys Leu Leu Leu 
1               5                   10                  15      


Pro Leu Leu Leu Leu Ala Ala Trp Lys Val Gly Ser Gly Gln Leu His 
            20                  25                  30          


Tyr Ser Val Pro Glu Glu Ala Lys His Gly Thr Phe Val Gly Arg Ile 
        35                  40                  45              


Ala Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Pro Arg Leu Phe 
    50                  55                  60                  


Arg Met Ala Ser Lys Asp Arg Glu Asp Leu Leu Glu Val Asn Leu Gln 
65                  70                  75                  80  


Asn Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Gly Arg Ser Ala Glu Cys Ser Ile His Leu Glu Val Ile Val Asp Arg 
            100                 105                 110         


Pro Leu Gln Val Phe His Val Asp Val Glu Val Arg Asp Ile Asn Asp 
        115                 120                 125             


Asn Pro Pro Leu Phe Pro Val Glu Glu Gln Arg Val Leu Ile Tyr Glu 
    130                 135                 140                 


Ser Arg Leu Pro Asp Ser Val Phe Pro Leu Glu Gly Ala Ser Asp Ala 
145                 150                 155                 160 


Asp Val Gly Ser Asn Ser Ile Leu Thr Tyr Lys Leu Ser Ser Ser Glu 
                165                 170                 175     


Tyr Phe Gly Leu Asp Val Lys Ile Asn Ser Asp Asp Asn Lys Gln Ile 
            180                 185                 190         


Gly Leu Leu Leu Lys Lys Ser Leu Asp Arg Glu Glu Ala Pro Ala His 
        195                 200                 205             


Asn Leu Phe Leu Thr Ala Thr Asp Gly Gly Lys Pro Glu Leu Thr Gly 
    210                 215                 220                 


Thr Val Gln Leu Leu Val Thr Val Leu Asp Val Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Thr Phe Glu Gln Ser Glu Tyr Glu Val Arg Ile Phe Glu Asn Ala Asp 
                245                 250                 255     


Asn Gly Thr Thr Val Ile Arg Leu Asn Ala Ser Asp Arg Asp Glu Gly 
            260                 265                 270         


Ala Asn Gly Ala Ile Ser Tyr Ser Phe Asn Ser Leu Val Ala Ala Met 
        275                 280                 285             


Val Ile Asp His Phe Ser Ile Asp Arg Asn Thr Gly Glu Ile Val Ile 
    290                 295                 300                 


Arg Gly Asn Leu Asp Phe Glu Gln Glu Asn Leu Tyr Lys Ile Leu Ile 
305                 310                 315                 320 


Asp Ala Thr Asp Lys Gly His Pro Pro Met Ala Gly His Cys Thr Val 
                325                 330                 335     


Leu Val Arg Ile Leu Asp Lys Asn Asp Asn Val Pro Glu Ile Ala Leu 
            340                 345                 350         


Thr Ser Leu Ser Leu Pro Val Arg Glu Asp Ala Gln Phe Gly Thr Val 
        355                 360                 365             


Ile Ala Leu Ile Ser Val Asn Asp Leu Asp Ser Gly Ala Asn Gly Gln 
    370                 375                 380                 


Val Asn Cys Ser Leu Thr Pro His Val Pro Phe Lys Leu Val Ser Thr 
385                 390                 395                 400 


Phe Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu 
                405                 410                 415     


Ser Val Ser Ala Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser 
            420                 425                 430         


Pro Ser Leu Trp Ala Thr Ala Ser Leu Ser Val Glu Val Ala Asp Met 
        435                 440                 445             


Asn Asp Asn Ala Pro Ala Phe Ala Gln Pro Glu Tyr Thr Val Phe Val 
    450                 455                 460                 


Lys Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Arg 
465                 470                 475                 480 


Asp Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu 
                485                 490                 495     


Arg Arg Val Gly Glu Arg Ala Leu Ser Ser Tyr Ile Ser Val His Ala 
            500                 505                 510         


Glu Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu 
        515                 520                 525             


Glu Leu Leu Gln Phe Gln Pro Arg Gln Pro Asn Pro Asp Trp Arg Tyr 
    530                 535                 540                 


Ser Ala Ser Leu Arg Ala Gly Met His Ser Ser Val His Leu Glu Glu 
545                 550                 555                 560 


Ala Gly Ile Leu Arg Ala Gly Pro Gly Gly Pro Asp Gln Gln Trp Pro 
                565                 570                 575     


Thr Val Ser Ser Ala Thr Pro Glu Pro Glu Ala Gly Glu Val Ser Pro 
            580                 585                 590         


Pro Val Gly Ala Gly Val Asn Ser Asn Ser Trp Thr Phe Lys Tyr Gly 
        595                 600                 605             


Pro Gly Asn Pro Lys Gln Ser Gly Pro Gly Glu Leu Pro Asp Lys Phe 
    610                 615                 620                 


Ile Ile Pro Gly Ser Pro Ala Ile Ile Ser Ile Arg Gln Glu Pro Thr 
625                 630                 635                 640 


Asn Ser Gln Ile Asp Lys Ser Asp Phe Ile Thr Phe Gly Lys Lys Glu 
                645                 650                 655     


Glu Thr Lys Lys Lys Lys Lys Lys Lys Lys Gly Asn Lys Thr Gln Glu 
            660                 665                 670         


Lys Lys Glu Lys Gly Asn Ser Thr Thr Asp Asn Ser Asp Gln 
        675                 680                 685     

<210>  235
<211>  5221
<212>  DNA
<213>  Homo sapiens

<400>  235
atggtgtgcc cgaatggata cgacccaggg ggccgacatc tactgctgtt tattataatt     60

ctagcagctt gggaggcagg gagaggccag ctccactact cggtccccga ggaggctaaa    120

catggcaact tcgtgggccg catcgcgcag gacctggggc tggagctggc ggagctggtg    180

ccgcgcctgt tccgggcggt gtgcaaattc cgtggggatc ttctggaggt aaatctgcag    240

aatggcattt tgtttgtgaa ttctcggatc gaccgcgagg agctgtgcgg gcggagcgcg    300

gagtgcagca tccacctgga ggtgatcgtg gaaaggccgc tgcaggtttt ccatgtggac    360

gtggaggtga aggacattaa cgacaaccct ccggtgttcc cagcgacaca aaggaatctg    420

ttcatcgcgg aatccaggcc gcttgactct cggtttccac tagagggcgc gtccgatgca    480

gatatcgggg agaacgccct gctcacttac agactgagcc ccaatgagta tttcttcctg    540

gacgtgccaa ccagcaacca gcaggtaaaa cctcttggac ttgtattacg gaaactttta    600

gacagagaag aaactccgga gcttcattta ttgctcacgg ccaccgatgg aggcaaaccc    660

gagctgactg gcaccgttca attactcatc acggtactgg acaacaatga caatgcccca    720

gtgttcgaca gaaccctgta tacggtgaaa ttaccagaaa acgtttctat cggaacgctg    780

gtgattcacc ccaatgcctc agatttagac gaaggcttga atggggatat tatttactcc    840

ttctccagtg atgtttctcc agatataaaa tccaagttcc acatggaccc cttaagtggg    900

gcaatcacag tgataggaca tatggatttt gaagaaagta gagcacacaa gatcccagtc    960

gaggctgtcg ataaaggctt cccacccctg gctggtcatt gtacagttct tgtggaagtt   1020

gtggatgtaa atgacaatgc tccacagttg actctcactt ccctgtctct ccctattcca   1080

gaggacgccc aaccaggtac cgtcatcaca ttgattagcg tgtttgaccg agattttgga   1140

gtcaacggac aggttacctg ctccctgacg ccccgcgttc ccttcaagtt ggtgtccacc   1200

ttcaagaatt actattcatt ggtgctggac agcgctctgg accgcgagag tgtgtccgcc   1260

tatgagctgg tggttaccgc gcgggacggg ggctcgcctt ctctgtgggc cactgctagc   1320

gtgtccgtgg aggtggccga cgtgaacgac aacgccccgg cgttcgcgca gcccgagtat   1380

acggtgttcg tgaaggagaa caacccgccg ggctgccaca tcttcactgt gtcggcgggg   1440

gacgcggacg cgcagaagaa cgcgctggtg tcctactcgc tggtggagct gcgggtgggc   1500

gagcgcgcgc tgtcgagcta cgtgtcagtg cacgcggaga gcggcaaggt gtacgcgctg   1560

cagccgttgg accacgagga gctggagctg ttgcagttcc aggtgagcgc gcgcgatgcg   1620

ggcgtgccgc ctctgggcag caacgtgacg ctgcaggtgt tcgtgctgga cgagaacgac   1680

aacgcgccgg cactgctggc gcctcgggtg ggtggcactg gtggcgcagt gagagagctt   1740

gtgccgcggt ctgtgggcgc gggccatgtg gtggcgaagg tacgtgcagt tgacgctgac   1800

tcaggctaca acgcgtggct ttcgtatgag ttgcaaccgg tggcggccgg tgcgagcatc   1860

ccgttccgcg tggggctgta cactggtgag atcagcacga cacgagccct agatgagacg   1920

gacgcaccgc gccaccgcct tctggtgctt gtgaaggacc acggggagcc ctcgctgaca   1980

gccacagcca ccgtgctggt gtcgctggtg gaaagcggcc aggcaccaaa ggcgtcgtcg   2040

cgggcatcgt tgggcattgc aggcccagag accgagctgg tggatgtcaa cgtgtacctg   2100

atcatcgcca tctgcgcggt gtccagtctg ttggtgctta ccctgctgct gtacacggcg   2160

ttgcggtgct cagcgccgtc ctctgagggc gcatgtagtt tggtaaagcc cactctggtg   2220

tgctccagcg cggtggggag ctggtcattc tcccagcaga ggcggcagag ggtgtgctct   2280

ggggagggcc cacccaagac agacctcatg gccttcagtc ccagccttcc tcagggtcca   2340

tcctctacag acaatccacg acagcccaac cctgactggc gttactctgc ctccctgaga   2400

gcaggcatgc acagctctgt gcacctagag gaggctggca ttctacgggc tggtccagga   2460

gggcctgatc agcagtggcc aacagtatcc agtgcaacac cagaaccaga ggcaggagaa   2520

gtgtcccctc cagtcggtgc gggtgtcaac agcaacagct ggacctttaa atacggacca   2580

ggcaacccca aacaatccgg tcccggtgag ttgcccgaca aattcattat cccaggatct   2640

cctgcaatca tctccatccg gcaggagcct actaacagcc aaattgacaa aagtgacttc   2700

ataaccttcg gcaaaaagga ggagaccaag aaaaagaaga aaaagaagaa gggtaacaag   2760

acccaggaga aaaaagagaa agggaacagc acgactgaca acagtgacca gtgaggtcct   2820

caaatggaaa caagccactt agccagtttt tgtaataatg gcaaatctct cccatgtagc   2880

aattccctgc tcctttttcc tatctacatg agccctctta gagacctcag aaatctgcag   2940

aaagttccct gtgtctgtct agaacgcatt taacaggttt tgtcgtaaaa gctttactaa   3000

gtctggtgtt aactctttct ctccactctg gcttgttttc agaacctaaa aagcagaccc   3060

aagtttcctt tctcctccgc cgcaaaggag aggcttccca gccccgccag tgagaggttg   3120

gactctctgc cctgtgctcc ggggatcctg tcttgatgac acttgcaggg caggctgaaa   3180

agttttgaga ttgagcagct tgggagtttg tggccactgg gtatgtgtgg ctaccgcggg   3240

tatgcgagtg ccagatattg gctgagacga gccagcttag actaattggt acaaggaagg   3300

caagaaaaca aagacaaata aacagcggaa gttatcagta tggaggggaa gtgtaaactt   3360

aaagggacca gactttctaa atcttacaac tcaagaggtg gcagccaccc tctaggagac   3420

aaaactaccc ccactgacaa ggctttagga gaccctaaag tctgttggct gtgacgtcat   3480

tatacctaaa atctgcatca tacctgcaag ccaacagttc agtgttttaa cagagaacca   3540

ccctgggaaa cagaagcaga tctgatgtgt ttcctataca tgtcctgtgc tcactttatt   3600

aaaaattctt ttgcacacaa tgtttatgaa aaggccagat ccttttccaa tacttatgca   3660

aaagcaaaag aaaaccccga cacctcacct ttcgctgttt gttgtttcat agatttattt   3720

aaaaaaagag aaagtctata gctataaatc tttaaagaga aatatgaata caattcccct   3780

aaactctcct caaaagagaa ttcagtctac agccatttaa atgatcattg ctgctacaga   3840

agtgctttaa gagaattgcc tgaaacatct gtattatatc ggccacctgc caatcacagc   3900

tttactcttt caggtcactc tggggctgcc tcttgcatgt attactaaat aaaatgatct   3960

ctctttctct ctctctctct cttttctaag aaacaattat gtgcactttg atacacaacc   4020

ttctctaacc aactatatat caagacccaa aaattgaaga aaaatattgt tttctcatac   4080

agtgagcaga tttttcaatc tactaattct gtgacttgtc ttggtgtgct agcctacacc   4140

ttctctttgg tttagttttc cttttctata acactctgaa ttgctaatct tactaacacc   4200

tatgatgtta cctgaaatca atctcccata tgtatgctgt atgctatgct aagactcctg   4260

aaatatactt actctgtgct tgtgtatgtg aatgttaatg caactattac ctagagtgaa   4320

ctttaagctt tattgttgaa tgtaattcca ttatatttcc ttttgtacac ctgtgaaaaa   4380

gtggagtagt gtttttttaa ccattgttaa tcagcttttg tgtatgaaag acacagtaaa   4440

atttctttct taaatcaaga tactggtgat tcaaggaatt ttatttatgg tccagccaag   4500

agccatctcg tgccaagact tctgctggca agggaatgga taaagctgtt ttgttctagt   4560

aacaattttg gaatgaatac tgacaatatt ccatgagggt gtgcaagcac aaattttacc   4620

aatctgacct ctttgaagtt gcagaatgct ttgaaattct aatggtatct gaaatatcag   4680

ctcatagaaa gtaacaaaat ttgctgtcac cttaaataag acattttaat tttgttataa   4740

tgtacaattt agaagtttga ttaattatat tatctattta ggcattaata taaaagaggt   4800

aggagtctgt tatttaaaaa aagcattaaa tttaaaaaaa aactgtcttg tctactttta   4860

gcttcattct cccatatttt gaagggtgtg taacttcagc tctgcaggat tgcatggggt   4920

aaaacttgtt accaacacat gtgaaccatt gctacattgt aggttgtgat cattttgccc   4980

cactgaagcc catgtatctg accttacgtg ccttttgaac taggagaatc gggctaattt   5040

attaatgatg ataattataa tgtatctgta cagcactttt tacatttgcg aagtgctttc   5100

caatccatgt tagttactag ttattacagc tgtaaggata aaacacgtca tgtggattca   5160

ttttgaattg gtgctattgg tatttcctct gttattgcta ataaatgaaa atggtggtat   5220

g                                                                   5221


<210>  236
<211>  937
<212>  PRT
<213>  Homo sapiens

<400>  236


Met Val Cys Pro Asn Gly Tyr Asp Pro Gly Gly Arg His Leu Leu Leu 
1               5                   10                  15      


Phe Ile Ile Ile Leu Ala Ala Trp Glu Ala Gly Arg Gly Gln Leu His 
            20                  25                  30          


Tyr Ser Val Pro Glu Glu Ala Lys His Gly Asn Phe Val Gly Arg Ile 
        35                  40                  45              


Ala Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Pro Arg Leu Phe 
    50                  55                  60                  


Arg Ala Val Cys Lys Phe Arg Gly Asp Leu Leu Glu Val Asn Leu Gln 
65                  70                  75                  80  


Asn Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Gly Arg Ser Ala Glu Cys Ser Ile His Leu Glu Val Ile Val Glu Arg 
            100                 105                 110         


Pro Leu Gln Val Phe His Val Asp Val Glu Val Lys Asp Ile Asn Asp 
        115                 120                 125             


Asn Pro Pro Val Phe Pro Ala Thr Gln Arg Asn Leu Phe Ile Ala Glu 
    130                 135                 140                 


Ser Arg Pro Leu Asp Ser Arg Phe Pro Leu Glu Gly Ala Ser Asp Ala 
145                 150                 155                 160 


Asp Ile Gly Glu Asn Ala Leu Leu Thr Tyr Arg Leu Ser Pro Asn Glu 
                165                 170                 175     


Tyr Phe Phe Leu Asp Val Pro Thr Ser Asn Gln Gln Val Lys Pro Leu 
            180                 185                 190         


Gly Leu Val Leu Arg Lys Leu Leu Asp Arg Glu Glu Thr Pro Glu Leu 
        195                 200                 205             


His Leu Leu Leu Thr Ala Thr Asp Gly Gly Lys Pro Glu Leu Thr Gly 
    210                 215                 220                 


Thr Val Gln Leu Leu Ile Thr Val Leu Asp Asn Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Val Phe Asp Arg Thr Leu Tyr Thr Val Lys Leu Pro Glu Asn Val Ser 
                245                 250                 255     


Ile Gly Thr Leu Val Ile His Pro Asn Ala Ser Asp Leu Asp Glu Gly 
            260                 265                 270         


Leu Asn Gly Asp Ile Ile Tyr Ser Phe Ser Ser Asp Val Ser Pro Asp 
        275                 280                 285             


Ile Lys Ser Lys Phe His Met Asp Pro Leu Ser Gly Ala Ile Thr Val 
    290                 295                 300                 


Ile Gly His Met Asp Phe Glu Glu Ser Arg Ala His Lys Ile Pro Val 
305                 310                 315                 320 


Glu Ala Val Asp Lys Gly Phe Pro Pro Leu Ala Gly His Cys Thr Val 
                325                 330                 335     


Leu Val Glu Val Val Asp Val Asn Asp Asn Ala Pro Gln Leu Thr Leu 
            340                 345                 350         


Thr Ser Leu Ser Leu Pro Ile Pro Glu Asp Ala Gln Pro Gly Thr Val 
        355                 360                 365             


Ile Thr Leu Ile Ser Val Phe Asp Arg Asp Phe Gly Val Asn Gly Gln 
    370                 375                 380                 


Val Thr Cys Ser Leu Thr Pro Arg Val Pro Phe Lys Leu Val Ser Thr 
385                 390                 395                 400 


Phe Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu 
                405                 410                 415     


Ser Val Ser Ala Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser 
            420                 425                 430         


Pro Ser Leu Trp Ala Thr Ala Ser Val Ser Val Glu Val Ala Asp Val 
        435                 440                 445             


Asn Asp Asn Ala Pro Ala Phe Ala Gln Pro Glu Tyr Thr Val Phe Val 
    450                 455                 460                 


Lys Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Gly 
465                 470                 475                 480 


Asp Ala Asp Ala Gln Lys Asn Ala Leu Val Ser Tyr Ser Leu Val Glu 
                485                 490                 495     


Leu Arg Val Gly Glu Arg Ala Leu Ser Ser Tyr Val Ser Val His Ala 
            500                 505                 510         


Glu Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu 
        515                 520                 525             


Glu Leu Leu Gln Phe Gln Val Ser Ala Arg Asp Ala Gly Val Pro Pro 
    530                 535                 540                 


Leu Gly Ser Asn Val Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp 
545                 550                 555                 560 


Asn Ala Pro Ala Leu Leu Ala Pro Arg Val Gly Gly Thr Gly Gly Ala 
                565                 570                 575     


Val Arg Glu Leu Val Pro Arg Ser Val Gly Ala Gly His Val Val Ala 
            580                 585                 590         


Lys Val Arg Ala Val Asp Ala Asp Ser Gly Tyr Asn Ala Trp Leu Ser 
        595                 600                 605             


Tyr Glu Leu Gln Pro Val Ala Ala Gly Ala Ser Ile Pro Phe Arg Val 
    610                 615                 620                 


Gly Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Ala Leu Asp Glu Thr 
625                 630                 635                 640 


Asp Ala Pro Arg His Arg Leu Leu Val Leu Val Lys Asp His Gly Glu 
                645                 650                 655     


Pro Ser Leu Thr Ala Thr Ala Thr Val Leu Val Ser Leu Val Glu Ser 
            660                 665                 670         


Gly Gln Ala Pro Lys Ala Ser Ser Arg Ala Ser Leu Gly Ile Ala Gly 
        675                 680                 685             


Pro Glu Thr Glu Leu Val Asp Val Asn Val Tyr Leu Ile Ile Ala Ile 
    690                 695                 700                 


Cys Ala Val Ser Ser Leu Leu Val Leu Thr Leu Leu Leu Tyr Thr Ala 
705                 710                 715                 720 


Leu Arg Cys Ser Ala Pro Ser Ser Glu Gly Ala Cys Ser Leu Val Lys 
                725                 730                 735     


Pro Thr Leu Val Cys Ser Ser Ala Val Gly Ser Trp Ser Phe Ser Gln 
            740                 745                 750         


Gln Arg Arg Gln Arg Val Cys Ser Gly Glu Gly Pro Pro Lys Thr Asp 
        755                 760                 765             


Leu Met Ala Phe Ser Pro Ser Leu Pro Gln Gly Pro Ser Ser Thr Asp 
    770                 775                 780                 


Asn Pro Arg Gln Pro Asn Pro Asp Trp Arg Tyr Ser Ala Ser Leu Arg 
785                 790                 795                 800 


Ala Gly Met His Ser Ser Val His Leu Glu Glu Ala Gly Ile Leu Arg 
                805                 810                 815     


Ala Gly Pro Gly Gly Pro Asp Gln Gln Trp Pro Thr Val Ser Ser Ala 
            820                 825                 830         


Thr Pro Glu Pro Glu Ala Gly Glu Val Ser Pro Pro Val Gly Ala Gly 
        835                 840                 845             


Val Asn Ser Asn Ser Trp Thr Phe Lys Tyr Gly Pro Gly Asn Pro Lys 
    850                 855                 860                 


Gln Ser Gly Pro Gly Glu Leu Pro Asp Lys Phe Ile Ile Pro Gly Ser 
865                 870                 875                 880 


Pro Ala Ile Ile Ser Ile Arg Gln Glu Pro Thr Asn Ser Gln Ile Asp 
                885                 890                 895     


Lys Ser Asp Phe Ile Thr Phe Gly Lys Lys Glu Glu Thr Lys Lys Lys 
            900                 905                 910         


Lys Lys Lys Lys Lys Gly Asn Lys Thr Gln Glu Lys Lys Glu Lys Gly 
        915                 920                 925             


Asn Ser Thr Thr Asp Asn Ser Asp Gln 
    930                 935         

<210>  237
<211>  2370
<212>  DNA
<213>  Homo sapiens

<400>  237
atggtgtgcc cgaatggata cgacccaggg ggccgacatc tactgctgtt tattataatt     60

ctagcagctt gggaggcagg gagaggccag ctccactact cggtccccga ggaggctaaa    120

catggcaact tcgtgggccg catcgcgcag gacctggggc tggagctggc ggagctggtg    180

ccgcgcctgt tccgggcggt gtgcaaattc cgtggggatc ttctggaggt aaatctgcag    240

aatggcattt tgtttgtgaa ttctcggatc gaccgcgagg agctgtgcgg gcggagcgcg    300

gagtgcagca tccacctgga ggtgatcgtg gaaaggccgc tgcaggtttt ccatgtggac    360

gtggaggtga aggacattaa cgacaaccct ccggtgttcc cagcgacaca aaggaatctg    420

ttcatcgcgg aatccaggcc gcttgactct cggtttccac tagagggcgc gtccgatgca    480

gatatcgggg agaacgccct gctcacttac agactgagcc ccaatgagta tttcttcctg    540

gacgtgccaa ccagcaacca gcaggtaaaa cctcttggac ttgtattacg gaaactttta    600

gacagagaag aaactccgga gcttcattta ttgctcacgg ccaccgatgg aggcaaaccc    660

gagctgactg gcaccgttca attactcatc acggtactgg acaacaatga caatgcccca    720

gtgttcgaca gaaccctgta tacggtgaaa ttaccagaaa acgtttctat cggaacgctg    780

gtgattcacc ccaatgcctc agatttagac gaaggcttga atggggatat tatttactcc    840

ttctccagtg atgtttctcc agatataaaa tccaagttcc acatggaccc cttaagtggg    900

gcaatcacag tgataggaca tatggatttt gaagaaagta gagcacacaa gatcccagtc    960

gaggctgtcg ataaaggctt cccacccctg gctggtcatt gtacagttct tgtggaagtt   1020

gtggatgtaa atgacaatgc tccacagttg actctcactt ccctgtctct ccctattcca   1080

gaggacgccc aaccaggtac cgtcatcaca ttgattagcg tgtttgaccg agattttgga   1140

gtcaacggac aggttacctg ctccctgacg ccccgcgttc ccttcaagtt ggtgtccacc   1200

ttcaagaatt actattcatt ggtgctggac agcgctctgg accgcgagag tgtgtccgcc   1260

tatgagctgg tggttaccgc gcgggacggg ggctcgcctt ctctgtgggc cactgctagc   1320

gtgtccgtgg aggtggccga cgtgaacgac aacgccccgg cgttcgcgca gcccgagtat   1380

acggtgttcg tgaaggagaa caacccgccg ggctgccaca tcttcactgt gtcggcgggg   1440

gacgcggacg cgcagaagaa cgcgctggtg tcctactcgc tggtggagct gcgggtgggc   1500

gagcgcgcgc tgtcgagcta cgtgtcagtg cacgcggaga gcggcaaggt gtacgcgctg   1560

cagccgttgg accacgagga gctggagctg ttgcagttcc aggtgagcgc gcgcgatgcg   1620

ggcgtgccgc ctctgggcag caacgtgacg ctgcaggtgt tcgtgctgga cgagaacgac   1680

aacgcgccgg cactgctggc gcctcgggtg ggtggcactg gtggcgcagt gagagagctt   1740

gtgccgcggt ctgtgggcgc gggccatgtg gtggcgaagg tacgtgcagt tgacgctgac   1800

tcaggctaca acgcgtggct ttcgtatgag ttgcaaccgg tggcggccgg tgcgagcatc   1860

ccgttccgcg tggggctgta cactggtgag atcagcacga cacgagccct agatgagacg   1920

gacgcaccgc gccaccgcct tctggtgctt gtgaaggacc acggggagcc ctcgctgaca   1980

gccacagcca ccgtgctggt gtcgctggtg gaaagcggcc aggcaccaaa ggcgtcgtcg   2040

cgggcatcgt tgggcattgc aggcccagag accgagctgg tggatgtcaa cgtgtacctg   2100

atcatcgcca tctgcgcggt gtccagtctg ttggtgctta ccctgctgct gtacacggcg   2160

ttgcggtgct cagcgccgtc ctctgagggc gcatgtagtt tggtaaagcc cactctggtg   2220

tgctccagcg cggtggggag ctggtcattc tcccagcaga ggcggcagag ggtgtgctct   2280

ggggagggcc cacccaagac agacctcatg gccttcagtc ccagccttcc tcagggtcca   2340

tcctctacag acaatgtgag tcataaataa                                    2370


<210>  238
<211>  789
<212>  PRT
<213>  Homo sapiens

<400>  238


Met Val Cys Pro Asn Gly Tyr Asp Pro Gly Gly Arg His Leu Leu Leu 
1               5                   10                  15      


Phe Ile Ile Ile Leu Ala Ala Trp Glu Ala Gly Arg Gly Gln Leu His 
            20                  25                  30          


Tyr Ser Val Pro Glu Glu Ala Lys His Gly Asn Phe Val Gly Arg Ile 
        35                  40                  45              


Ala Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Pro Arg Leu Phe 
    50                  55                  60                  


Arg Ala Val Cys Lys Phe Arg Gly Asp Leu Leu Glu Val Asn Leu Gln 
65                  70                  75                  80  


Asn Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Gly Arg Ser Ala Glu Cys Ser Ile His Leu Glu Val Ile Val Glu Arg 
            100                 105                 110         


Pro Leu Gln Val Phe His Val Asp Val Glu Val Lys Asp Ile Asn Asp 
        115                 120                 125             


Asn Pro Pro Val Phe Pro Ala Thr Gln Arg Asn Leu Phe Ile Ala Glu 
    130                 135                 140                 


Ser Arg Pro Leu Asp Ser Arg Phe Pro Leu Glu Gly Ala Ser Asp Ala 
145                 150                 155                 160 


Asp Ile Gly Glu Asn Ala Leu Leu Thr Tyr Arg Leu Ser Pro Asn Glu 
                165                 170                 175     


Tyr Phe Phe Leu Asp Val Pro Thr Ser Asn Gln Gln Val Lys Pro Leu 
            180                 185                 190         


Gly Leu Val Leu Arg Lys Leu Leu Asp Arg Glu Glu Thr Pro Glu Leu 
        195                 200                 205             


His Leu Leu Leu Thr Ala Thr Asp Gly Gly Lys Pro Glu Leu Thr Gly 
    210                 215                 220                 


Thr Val Gln Leu Leu Ile Thr Val Leu Asp Asn Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Val Phe Asp Arg Thr Leu Tyr Thr Val Lys Leu Pro Glu Asn Val Ser 
                245                 250                 255     


Ile Gly Thr Leu Val Ile His Pro Asn Ala Ser Asp Leu Asp Glu Gly 
            260                 265                 270         


Leu Asn Gly Asp Ile Ile Tyr Ser Phe Ser Ser Asp Val Ser Pro Asp 
        275                 280                 285             


Ile Lys Ser Lys Phe His Met Asp Pro Leu Ser Gly Ala Ile Thr Val 
    290                 295                 300                 


Ile Gly His Met Asp Phe Glu Glu Ser Arg Ala His Lys Ile Pro Val 
305                 310                 315                 320 


Glu Ala Val Asp Lys Gly Phe Pro Pro Leu Ala Gly His Cys Thr Val 
                325                 330                 335     


Leu Val Glu Val Val Asp Val Asn Asp Asn Ala Pro Gln Leu Thr Leu 
            340                 345                 350         


Thr Ser Leu Ser Leu Pro Ile Pro Glu Asp Ala Gln Pro Gly Thr Val 
        355                 360                 365             


Ile Thr Leu Ile Ser Val Phe Asp Arg Asp Phe Gly Val Asn Gly Gln 
    370                 375                 380                 


Val Thr Cys Ser Leu Thr Pro Arg Val Pro Phe Lys Leu Val Ser Thr 
385                 390                 395                 400 


Phe Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu 
                405                 410                 415     


Ser Val Ser Ala Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser 
            420                 425                 430         


Pro Ser Leu Trp Ala Thr Ala Ser Val Ser Val Glu Val Ala Asp Val 
        435                 440                 445             


Asn Asp Asn Ala Pro Ala Phe Ala Gln Pro Glu Tyr Thr Val Phe Val 
    450                 455                 460                 


Lys Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Gly 
465                 470                 475                 480 


Asp Ala Asp Ala Gln Lys Asn Ala Leu Val Ser Tyr Ser Leu Val Glu 
                485                 490                 495     


Leu Arg Val Gly Glu Arg Ala Leu Ser Ser Tyr Val Ser Val His Ala 
            500                 505                 510         


Glu Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu 
        515                 520                 525             


Glu Leu Leu Gln Phe Gln Val Ser Ala Arg Asp Ala Gly Val Pro Pro 
    530                 535                 540                 


Leu Gly Ser Asn Val Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp 
545                 550                 555                 560 


Asn Ala Pro Ala Leu Leu Ala Pro Arg Val Gly Gly Thr Gly Gly Ala 
                565                 570                 575     


Val Arg Glu Leu Val Pro Arg Ser Val Gly Ala Gly His Val Val Ala 
            580                 585                 590         


Lys Val Arg Ala Val Asp Ala Asp Ser Gly Tyr Asn Ala Trp Leu Ser 
        595                 600                 605             


Tyr Glu Leu Gln Pro Val Ala Ala Gly Ala Ser Ile Pro Phe Arg Val 
    610                 615                 620                 


Gly Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Ala Leu Asp Glu Thr 
625                 630                 635                 640 


Asp Ala Pro Arg His Arg Leu Leu Val Leu Val Lys Asp His Gly Glu 
                645                 650                 655     


Pro Ser Leu Thr Ala Thr Ala Thr Val Leu Val Ser Leu Val Glu Ser 
            660                 665                 670         


Gly Gln Ala Pro Lys Ala Ser Ser Arg Ala Ser Leu Gly Ile Ala Gly 
        675                 680                 685             


Pro Glu Thr Glu Leu Val Asp Val Asn Val Tyr Leu Ile Ile Ala Ile 
    690                 695                 700                 


Cys Ala Val Ser Ser Leu Leu Val Leu Thr Leu Leu Leu Tyr Thr Ala 
705                 710                 715                 720 


Leu Arg Cys Ser Ala Pro Ser Ser Glu Gly Ala Cys Ser Leu Val Lys 
                725                 730                 735     


Pro Thr Leu Val Cys Ser Ser Ala Val Gly Ser Trp Ser Phe Ser Gln 
            740                 745                 750         


Gln Arg Arg Gln Arg Val Cys Ser Gly Glu Gly Pro Pro Lys Thr Asp 
        755                 760                 765             


Leu Met Ala Phe Ser Pro Ser Leu Pro Gln Gly Pro Ser Ser Thr Asp 
    770                 775                 780                 


Asn Val Ser His Lys 
785                 

<210>  239
<211>  5260
<212>  DNA
<213>  Homo sapiens

<400>  239
atggattatc actggcgagg agagctggga tcctggcgac tactactctt gcttctgctc     60

ctcgcagcct ggaaggtggg gagcggccag ctccactact ccgtccccga ggaggccaaa    120

cacggcacct tcgtgggccg gatcgcgcag gacctggggc tggagctggc ggagctggtg    180

ccgcgcctgt tccgggtggc gtccaaaaga caccgggacc ttctggaggt aagtctgcag    240

aatggcattt tgtttgtgaa ttctcggatc gaccgcgagg agctgtgcgg gcggagcgcg    300

gagtgcagca tccacctgga ggtgatcgtg gacaggccgc tgcaggtttt ccatgtggac    360

gtggaggtga aggatgttaa tgacaacccg ccagtgttcc gggtaaaaga ccaaaagctg    420

tttgtttcag aatccagaat gccagactct cggtttccgc tagagggcgc gtccgatgca    480

gatgttggag ctaactccgt gttaacctac aggcttagct ctcatgatta cttcatgcta    540

gatgtgaatt caaagaacga tgagaataaa ctggttgagc tcgtattaag aaaatccttg    600

gacagagagg acgctcctgc gcaccactta ttcctgacag ccacagatgg gggcaaacct    660

gagctcacag gcactgttca gctgctggtc acagtgctgg atgtgaatga taatgctccc    720

actttcgaac agtctgaata cgaagtaaga atattcgaaa acgcagacaa cggaacaaca    780

gttatcaaac tgaatgcttc tgatccggat gaaggagcca atggggcaat ttcatattct    840

tttaatagcc ttgttgaaac tatggttatt gaccacttta gcatagatcg aaatacggga    900

gaaatagtga ttcggggtaa tttggatttt gaacaagaaa acttatacaa aatcctcatt    960

gacgccacgg acaaaggcca tcctcccatg gcgggtcatt gcaccgtttt agtgagaatt   1020

ttggataaaa atgataacgt ccctgagata gcactgactt ccttatcctt gcctgtacgt   1080

gaagacgctc aatttggtac tgtcatcgcc ctaattagcg tgaacgacct cgattcaggt   1140

gccaacgggc aggtgacctg ctccctgatg ccccatgtcc ccttcaagct ggtgtccacc   1200

ttcaagaatt actactcgtt ggtgctggac agcgccctgg accgcgagag agtgtcggcc   1260

tatgagttgg tggtaaccgc gcgggacggg ggctcgcctt cgctgtgggc caccgccagc   1320

ttgtctgtgg aggtggccga cgtgaacgac aatgctccgg cgttcgcgca gcccgagtac   1380

acggtgttcg tgaaggagaa caacccgccg ggctgccaca tcttcacggt gtctgcgcga   1440

gacgcggacg cgcaggagaa cgcgctggtg tcctactcgc ttgtggagcg gcgggtgggc   1500

gagcgctcgc tgtcgagcta catttcggtg cacacggaga gcggcaaggt gtacgcgctg   1560

cagccgctgg accacgagga gctagagctg ctgcagttcc aggtgagcgc gcgcgacgcg   1620

ggcgtgccgc ctctgggcag caacgtgacg ctgcaggtgt tcgtgctgga cgagaatgac   1680

aacgcgccgg cactgctgga gcctcgggtg ggtggcactg gtggcgcagc gagcaagctg   1740

gtgccgcggt ctgtgggcgc gggccacgtg gtagcgaagg tgcgcgcagt ggacgccgac   1800

tcgggctaca acgcgtggct ttcgtatgag ctgcagccag ctgcaagcag ccctcgcatc   1860

ccgttccgcg tggggctgta cacgggcgag atcagcacca ctcgtgtcct ggacgaagcg   1920

gactctccgc gccaccgtct gctggtcctg gtgaaggatc atggtgaacc tgcgctgacc   1980

gccacggcca cggttctggt gtcgctggtg gagagcggcc aggctccaaa agcgtcatcg   2040

aggcagtcgg ctggcgtttt gggtccggaa gcggcgctgg tggatgtcaa cgtgtacctg   2100

atcatcgcca tctgcgcggt atccagcctg ctggtgctca cgctgctgct gtacactgcg   2160

ctgcggtgct cagcactgcc cactgagggc gggtgccggg cgggcaagcc cactctggtg   2220

tgctccagtg cggtggggag ctggtcatac tcgcaacaac agccgcagag ggtgtgctct   2280

ggtgaggggc caccgaagac ggacctcatg gccttcagcc cctgccttcc tcctgatctg   2340

ggatcagttg atgtaggcga agagcaagat ttaaatgttg atcatggcct caaaccacga   2400

cagcccaacc ctgactggcg ttactctgcc tccctgagag caggcatgca cagctctgtg   2460

cacctagagg aggctggcat tctacgggct ggtccaggag ggcctgatca gcagtggcca   2520

acagtatcca gtgcaacacc agaaccagag gcaggagaag tgtcccctcc agtcggtgcg   2580

ggtgtcaaca gcaacagctg gacctttaaa tacggaccag gcaaccccaa acaatccggt   2640

cccggtgagt tgcccgacaa attcattatc ccaggatctc ctgcaatcat ctccatccgg   2700

caggagccta ctaacagcca aattgacaaa agtgacttca taaccttcgg caaaaaggag   2760

gagaccaaga aaaagaagaa aaagaagaag ggtaacaaga cccaggagaa aaaagagaaa   2820

gggaacagca cgactgacaa cagtgaccag tgaggtcctc aaatggaaac aagccactta   2880

gccagttttt gtaataatgg caaatctctc ccatgtagca attccctgct cctttttcct   2940

atctacatga gccctcttag agacctcaga aatctgcaga aagttccctg tgtctgtcta   3000

gaacgcattt aacaggtttt gtcgtaaaag ctttactaag tctggtgtta actctttctc   3060

tccactctgg cttgttttca gaacctaaaa agcagaccca agtttccttt ctcctccgcc   3120

gcaaaggaga ggcttcccag ccccgccagt gagaggttgg actctctgcc ctgtgctccg   3180

gggatcctgt cttgatgaca cttgcagggc aggctgaaaa gttttgagat tgagcagctt   3240

gggagtttgt ggccactggg tatgtgtggc taccgcgggt atgcgagtgc cagatattgg   3300

ctgagacgag ccagcttaga ctaattggta caaggaaggc aagaaaacaa agacaaataa   3360

acagcggaag ttatcagtat ggaggggaag tgtaaactta aagggaccag actttctaaa   3420

tcttacaact caagaggtgg cagccaccct ctaggagaca aaactacccc cactgacaag   3480

gctttaggag accctaaagt ctgttggctg tgacgtcatt atacctaaaa tctgcatcat   3540

acctgcaagc caacagttca gtgttttaac agagaaccac cctgggaaac agaagcagat   3600

ctgatgtgtt tcctatacat gtcctgtgct cactttatta aaaattcttt tgcacacaat   3660

gtttatgaaa aggccagatc cttttccaat acttatgcaa aagcaaaaga aaaccccgac   3720

acctcacctt tcgctgtttg ttgtttcata gatttattta aaaaaagaga aagtctatag   3780

ctataaatct ttaaagagaa atatgaatac aattccccta aactctcctc aaaagagaat   3840

tcagtctaca gccatttaaa tgatcattgc tgctacagaa gtgctttaag agaattgcct   3900

gaaacatctg tattatatcg gccacctgcc aatcacagct ttactctttc aggtcactct   3960

ggggctgcct cttgcatgta ttactaaata aaatgatctc tctttctctc tctctctctc   4020

ttttctaaga aacaattatg tgcactttga tacacaacct tctctaacca actatatatc   4080

aagacccaaa aattgaagaa aaatattgtt ttctcataca gtgagcagat ttttcaatct   4140

actaattctg tgacttgtct tggtgtgcta gcctacacct tctctttggt ttagttttcc   4200

ttttctataa cactctgaat tgctaatctt actaacacct atgatgttac ctgaaatcaa   4260

tctcccatat gtatgctgta tgctatgcta agactcctga aatatactta ctctgtgctt   4320

gtgtatgtga atgttaatgc aactattacc tagagtgaac tttaagcttt attgttgaat   4380

gtaattccat tatatttcct tttgtacacc tgtgaaaaag tggagtagtg tttttttaac   4440

cattgttaat cagcttttgt gtatgaaaga cacagtaaaa tttctttctt aaatcaagat   4500

actggtgatt caaggaattt tatttatggt ccagccaaga gccatctcgt gccaagactt   4560

ctgctggcaa gggaatggat aaagctgttt tgttctagta acaattttgg aatgaatact   4620

gacaatattc catgagggtg tgcaagcaca aattttacca atctgacctc tttgaagttg   4680

cagaatgctt tgaaattcta atggtatctg aaatatcagc tcatagaaag taacaaaatt   4740

tgctgtcacc ttaaataaga cattttaatt ttgttataat gtacaattta gaagtttgat   4800

taattatatt atctatttag gcattaatat aaaagaggta ggagtctgtt atttaaaaaa   4860

agcattaaat ttaaaaaaaa actgtcttgt ctacttttag cttcattctc ccatattttg   4920

aagggtgtgt aacttcagct ctgcaggatt gcatggggta aaacttgtta ccaacacatg   4980

tgaaccattg ctacattgta ggttgtgatc attttgcccc actgaagccc atgtatctga   5040

ccttacgtgc cttttgaact aggagaatcg ggctaattta ttaatgatga taattataat   5100

gtatctgtac agcacttttt acatttgcga agtgctttcc aatccatgtt agttactagt   5160

tattacagct gtaaggataa aacacgtcat gtggattcat tttgaattgg tgctattggt   5220

atttcctctg ttattgctaa taaatgaaaa tggtggtatg                         5260


<210>  240
<211>  950
<212>  PRT
<213>  Homo sapiens

<400>  240


Met Asp Tyr His Trp Arg Gly Glu Leu Gly Ser Trp Arg Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Ala Ala Trp Lys Val Gly Ser Gly Gln Leu His 
            20                  25                  30          


Tyr Ser Val Pro Glu Glu Ala Lys His Gly Thr Phe Val Gly Arg Ile 
        35                  40                  45              


Ala Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Pro Arg Leu Phe 
    50                  55                  60                  


Arg Val Ala Ser Lys Arg His Arg Asp Leu Leu Glu Val Ser Leu Gln 
65                  70                  75                  80  


Asn Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Gly Arg Ser Ala Glu Cys Ser Ile His Leu Glu Val Ile Val Asp Arg 
            100                 105                 110         


Pro Leu Gln Val Phe His Val Asp Val Glu Val Lys Asp Val Asn Asp 
        115                 120                 125             


Asn Pro Pro Val Phe Arg Val Lys Asp Gln Lys Leu Phe Val Ser Glu 
    130                 135                 140                 


Ser Arg Met Pro Asp Ser Arg Phe Pro Leu Glu Gly Ala Ser Asp Ala 
145                 150                 155                 160 


Asp Val Gly Ala Asn Ser Val Leu Thr Tyr Arg Leu Ser Ser His Asp 
                165                 170                 175     


Tyr Phe Met Leu Asp Val Asn Ser Lys Asn Asp Glu Asn Lys Leu Val 
            180                 185                 190         


Glu Leu Val Leu Arg Lys Ser Leu Asp Arg Glu Asp Ala Pro Ala His 
        195                 200                 205             


His Leu Phe Leu Thr Ala Thr Asp Gly Gly Lys Pro Glu Leu Thr Gly 
    210                 215                 220                 


Thr Val Gln Leu Leu Val Thr Val Leu Asp Val Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Thr Phe Glu Gln Ser Glu Tyr Glu Val Arg Ile Phe Glu Asn Ala Asp 
                245                 250                 255     


Asn Gly Thr Thr Val Ile Lys Leu Asn Ala Ser Asp Pro Asp Glu Gly 
            260                 265                 270         


Ala Asn Gly Ala Ile Ser Tyr Ser Phe Asn Ser Leu Val Glu Thr Met 
        275                 280                 285             


Val Ile Asp His Phe Ser Ile Asp Arg Asn Thr Gly Glu Ile Val Ile 
    290                 295                 300                 


Arg Gly Asn Leu Asp Phe Glu Gln Glu Asn Leu Tyr Lys Ile Leu Ile 
305                 310                 315                 320 


Asp Ala Thr Asp Lys Gly His Pro Pro Met Ala Gly His Cys Thr Val 
                325                 330                 335     


Leu Val Arg Ile Leu Asp Lys Asn Asp Asn Val Pro Glu Ile Ala Leu 
            340                 345                 350         


Thr Ser Leu Ser Leu Pro Val Arg Glu Asp Ala Gln Phe Gly Thr Val 
        355                 360                 365             


Ile Ala Leu Ile Ser Val Asn Asp Leu Asp Ser Gly Ala Asn Gly Gln 
    370                 375                 380                 


Val Thr Cys Ser Leu Met Pro His Val Pro Phe Lys Leu Val Ser Thr 
385                 390                 395                 400 


Phe Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu 
                405                 410                 415     


Arg Val Ser Ala Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser 
            420                 425                 430         


Pro Ser Leu Trp Ala Thr Ala Ser Leu Ser Val Glu Val Ala Asp Val 
        435                 440                 445             


Asn Asp Asn Ala Pro Ala Phe Ala Gln Pro Glu Tyr Thr Val Phe Val 
    450                 455                 460                 


Lys Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Arg 
465                 470                 475                 480 


Asp Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu 
                485                 490                 495     


Arg Arg Val Gly Glu Arg Ser Leu Ser Ser Tyr Ile Ser Val His Thr 
            500                 505                 510         


Glu Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu 
        515                 520                 525             


Glu Leu Leu Gln Phe Gln Val Ser Ala Arg Asp Ala Gly Val Pro Pro 
    530                 535                 540                 


Leu Gly Ser Asn Val Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp 
545                 550                 555                 560 


Asn Ala Pro Ala Leu Leu Glu Pro Arg Val Gly Gly Thr Gly Gly Ala 
                565                 570                 575     


Ala Ser Lys Leu Val Pro Arg Ser Val Gly Ala Gly His Val Val Ala 
            580                 585                 590         


Lys Val Arg Ala Val Asp Ala Asp Ser Gly Tyr Asn Ala Trp Leu Ser 
        595                 600                 605             


Tyr Glu Leu Gln Pro Ala Ala Ser Ser Pro Arg Ile Pro Phe Arg Val 
    610                 615                 620                 


Gly Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Val Leu Asp Glu Ala 
625                 630                 635                 640 


Asp Ser Pro Arg His Arg Leu Leu Val Leu Val Lys Asp His Gly Glu 
                645                 650                 655     


Pro Ala Leu Thr Ala Thr Ala Thr Val Leu Val Ser Leu Val Glu Ser 
            660                 665                 670         


Gly Gln Ala Pro Lys Ala Ser Ser Arg Gln Ser Ala Gly Val Leu Gly 
        675                 680                 685             


Pro Glu Ala Ala Leu Val Asp Val Asn Val Tyr Leu Ile Ile Ala Ile 
    690                 695                 700                 


Cys Ala Val Ser Ser Leu Leu Val Leu Thr Leu Leu Leu Tyr Thr Ala 
705                 710                 715                 720 


Leu Arg Cys Ser Ala Leu Pro Thr Glu Gly Gly Cys Arg Ala Gly Lys 
                725                 730                 735     


Pro Thr Leu Val Cys Ser Ser Ala Val Gly Ser Trp Ser Tyr Ser Gln 
            740                 745                 750         


Gln Gln Pro Gln Arg Val Cys Ser Gly Glu Gly Pro Pro Lys Thr Asp 
        755                 760                 765             


Leu Met Ala Phe Ser Pro Cys Leu Pro Pro Asp Leu Gly Ser Val Asp 
    770                 775                 780                 


Val Gly Glu Glu Gln Asp Leu Asn Val Asp His Gly Leu Lys Pro Arg 
785                 790                 795                 800 


Gln Pro Asn Pro Asp Trp Arg Tyr Ser Ala Ser Leu Arg Ala Gly Met 
                805                 810                 815     


His Ser Ser Val His Leu Glu Glu Ala Gly Ile Leu Arg Ala Gly Pro 
            820                 825                 830         


Gly Gly Pro Asp Gln Gln Trp Pro Thr Val Ser Ser Ala Thr Pro Glu 
        835                 840                 845             


Pro Glu Ala Gly Glu Val Ser Pro Pro Val Gly Ala Gly Val Asn Ser 
    850                 855                 860                 


Asn Ser Trp Thr Phe Lys Tyr Gly Pro Gly Asn Pro Lys Gln Ser Gly 
865                 870                 875                 880 


Pro Gly Glu Leu Pro Asp Lys Phe Ile Ile Pro Gly Ser Pro Ala Ile 
                885                 890                 895     


Ile Ser Ile Arg Gln Glu Pro Thr Asn Ser Gln Ile Asp Lys Ser Asp 
            900                 905                 910         


Phe Ile Thr Phe Gly Lys Lys Glu Glu Thr Lys Lys Lys Lys Lys Lys 
        915                 920                 925             


Lys Lys Gly Asn Lys Thr Gln Glu Lys Lys Glu Lys Gly Asn Ser Thr 
    930                 935                 940                 


Thr Asp Asn Ser Asp Gln 
945                 950 

<210>  241
<211>  2445
<212>  DNA
<213>  Homo sapiens

<400>  241
atggattatc actggcgagg agagctggga tcctggcgac tactactctt gcttctgctc     60

ctcgcagcct ggaaggtggg gagcggccag ctccactact ccgtccccga ggaggccaaa    120

cacggcacct tcgtgggccg gatcgcgcag gacctggggc tggagctggc ggagctggtg    180

ccgcgcctgt tccgggtggc gtccaaaaga caccgggacc ttctggaggt aagtctgcag    240

aatggcattt tgtttgtgaa ttctcggatc gaccgcgagg agctgtgcgg gcggagcgcg    300

gagtgcagca tccacctgga ggtgatcgtg gacaggccgc tgcaggtttt ccatgtggac    360

gtggaggtga aggatgttaa tgacaacccg ccagtgttcc gggtaaaaga ccaaaagctg    420

tttgtttcag aatccagaat gccagactct cggtttccgc tagagggcgc gtccgatgca    480

gatgttggag ctaactccgt gttaacctac aggcttagct ctcatgatta cttcatgcta    540

gatgtgaatt caaagaacga tgagaataaa ctggttgagc tcgtattaag aaaatccttg    600

gacagagagg acgctcctgc gcaccactta ttcctgacag ccacagatgg gggcaaacct    660

gagctcacag gcactgttca gctgctggtc acagtgctgg atgtgaatga taatgctccc    720

actttcgaac agtctgaata cgaagtaaga atattcgaaa acgcagacaa cggaacaaca    780

gttatcaaac tgaatgcttc tgatccggat gaaggagcca atggggcaat ttcatattct    840

tttaatagcc ttgttgaaac tatggttatt gaccacttta gcatagatcg aaatacggga    900

gaaatagtga ttcggggtaa tttggatttt gaacaagaaa acttatacaa aatcctcatt    960

gacgccacgg acaaaggcca tcctcccatg gcgggtcatt gcaccgtttt agtgagaatt   1020

ttggataaaa atgataacgt ccctgagata gcactgactt ccttatcctt gcctgtacgt   1080

gaagacgctc aatttggtac tgtcatcgcc ctaattagcg tgaacgacct cgattcaggt   1140

gccaacgggc aggtgacctg ctccctgatg ccccatgtcc ccttcaagct ggtgtccacc   1200

ttcaagaatt actactcgtt ggtgctggac agcgccctgg accgcgagag agtgtcggcc   1260

tatgagttgg tggtaaccgc gcgggacggg ggctcgcctt cgctgtgggc caccgccagc   1320

ttgtctgtgg aggtggccga cgtgaacgac aatgctccgg cgttcgcgca gcccgagtac   1380

acggtgttcg tgaaggagaa caacccgccg ggctgccaca tcttcacggt gtctgcgcga   1440

gacgcggacg cgcaggagaa cgcgctggtg tcctactcgc ttgtggagcg gcgggtgggc   1500

gagcgctcgc tgtcgagcta catttcggtg cacacggaga gcggcaaggt gtacgcgctg   1560

cagccgctgg accacgagga gctagagctg ctgcagttcc aggtgagcgc gcgcgacgcg   1620

ggcgtgccgc ctctgggcag caacgtgacg ctgcaggtgt tcgtgctgga cgagaatgac   1680

aacgcgccgg cactgctgga gcctcgggtg ggtggcactg gtggcgcagc gagcaagctg   1740

gtgccgcggt ctgtgggcgc gggccacgtg gtagcgaagg tgcgcgcagt ggacgccgac   1800

tcgggctaca acgcgtggct ttcgtatgag ctgcagccag ctgcaagcag ccctcgcatc   1860

ccgttccgcg tggggctgta cacgggcgag atcagcacca ctcgtgtcct ggacgaagcg   1920

gactctccgc gccaccgtct gctggtcctg gtgaaggatc atggtgaacc tgcgctgacc   1980

gccacggcca cggttctggt gtcgctggtg gagagcggcc aggctccaaa agcgtcatcg   2040

aggcagtcgg ctggcgtttt gggtccggaa gcggcgctgg tggatgtcaa cgtgtacctg   2100

atcatcgcca tctgcgcggt atccagcctg ctggtgctca cgctgctgct gtacactgcg   2160

ctgcggtgct cagcactgcc cactgagggc gggtgccggg cgggcaagcc cactctggtg   2220

tgctccagtg cggtggggag ctggtcatac tcgcaacaac agccgcagag ggtgtgctct   2280

ggtgaggggc caccgaagac ggacctcatg gccttcagcc cctgccttcc tcctgatctg   2340

ggatcagttg atgtaggcga agagcaagat ttaaatgttg atcatggcct caaagtaagt   2400

ccatttaaat ttagaactca taaattctat ttgtggaaat tgtag                   2445


<210>  242
<211>  814
<212>  PRT
<213>  Homo sapiens

<400>  242


Met Asp Tyr His Trp Arg Gly Glu Leu Gly Ser Trp Arg Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Ala Ala Trp Lys Val Gly Ser Gly Gln Leu His 
            20                  25                  30          


Tyr Ser Val Pro Glu Glu Ala Lys His Gly Thr Phe Val Gly Arg Ile 
        35                  40                  45              


Ala Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Pro Arg Leu Phe 
    50                  55                  60                  


Arg Val Ala Ser Lys Arg His Arg Asp Leu Leu Glu Val Ser Leu Gln 
65                  70                  75                  80  


Asn Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Gly Arg Ser Ala Glu Cys Ser Ile His Leu Glu Val Ile Val Asp Arg 
            100                 105                 110         


Pro Leu Gln Val Phe His Val Asp Val Glu Val Lys Asp Val Asn Asp 
        115                 120                 125             


Asn Pro Pro Val Phe Arg Val Lys Asp Gln Lys Leu Phe Val Ser Glu 
    130                 135                 140                 


Ser Arg Met Pro Asp Ser Arg Phe Pro Leu Glu Gly Ala Ser Asp Ala 
145                 150                 155                 160 


Asp Val Gly Ala Asn Ser Val Leu Thr Tyr Arg Leu Ser Ser His Asp 
                165                 170                 175     


Tyr Phe Met Leu Asp Val Asn Ser Lys Asn Asp Glu Asn Lys Leu Val 
            180                 185                 190         


Glu Leu Val Leu Arg Lys Ser Leu Asp Arg Glu Asp Ala Pro Ala His 
        195                 200                 205             


His Leu Phe Leu Thr Ala Thr Asp Gly Gly Lys Pro Glu Leu Thr Gly 
    210                 215                 220                 


Thr Val Gln Leu Leu Val Thr Val Leu Asp Val Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Thr Phe Glu Gln Ser Glu Tyr Glu Val Arg Ile Phe Glu Asn Ala Asp 
                245                 250                 255     


Asn Gly Thr Thr Val Ile Lys Leu Asn Ala Ser Asp Pro Asp Glu Gly 
            260                 265                 270         


Ala Asn Gly Ala Ile Ser Tyr Ser Phe Asn Ser Leu Val Glu Thr Met 
        275                 280                 285             


Val Ile Asp His Phe Ser Ile Asp Arg Asn Thr Gly Glu Ile Val Ile 
    290                 295                 300                 


Arg Gly Asn Leu Asp Phe Glu Gln Glu Asn Leu Tyr Lys Ile Leu Ile 
305                 310                 315                 320 


Asp Ala Thr Asp Lys Gly His Pro Pro Met Ala Gly His Cys Thr Val 
                325                 330                 335     


Leu Val Arg Ile Leu Asp Lys Asn Asp Asn Val Pro Glu Ile Ala Leu 
            340                 345                 350         


Thr Ser Leu Ser Leu Pro Val Arg Glu Asp Ala Gln Phe Gly Thr Val 
        355                 360                 365             


Ile Ala Leu Ile Ser Val Asn Asp Leu Asp Ser Gly Ala Asn Gly Gln 
    370                 375                 380                 


Val Thr Cys Ser Leu Met Pro His Val Pro Phe Lys Leu Val Ser Thr 
385                 390                 395                 400 


Phe Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu 
                405                 410                 415     


Arg Val Ser Ala Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser 
            420                 425                 430         


Pro Ser Leu Trp Ala Thr Ala Ser Leu Ser Val Glu Val Ala Asp Val 
        435                 440                 445             


Asn Asp Asn Ala Pro Ala Phe Ala Gln Pro Glu Tyr Thr Val Phe Val 
    450                 455                 460                 


Lys Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Arg 
465                 470                 475                 480 


Asp Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu 
                485                 490                 495     


Arg Arg Val Gly Glu Arg Ser Leu Ser Ser Tyr Ile Ser Val His Thr 
            500                 505                 510         


Glu Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu 
        515                 520                 525             


Glu Leu Leu Gln Phe Gln Val Ser Ala Arg Asp Ala Gly Val Pro Pro 
    530                 535                 540                 


Leu Gly Ser Asn Val Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp 
545                 550                 555                 560 


Asn Ala Pro Ala Leu Leu Glu Pro Arg Val Gly Gly Thr Gly Gly Ala 
                565                 570                 575     


Ala Ser Lys Leu Val Pro Arg Ser Val Gly Ala Gly His Val Val Ala 
            580                 585                 590         


Lys Val Arg Ala Val Asp Ala Asp Ser Gly Tyr Asn Ala Trp Leu Ser 
        595                 600                 605             


Tyr Glu Leu Gln Pro Ala Ala Ser Ser Pro Arg Ile Pro Phe Arg Val 
    610                 615                 620                 


Gly Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Val Leu Asp Glu Ala 
625                 630                 635                 640 


Asp Ser Pro Arg His Arg Leu Leu Val Leu Val Lys Asp His Gly Glu 
                645                 650                 655     


Pro Ala Leu Thr Ala Thr Ala Thr Val Leu Val Ser Leu Val Glu Ser 
            660                 665                 670         


Gly Gln Ala Pro Lys Ala Ser Ser Arg Gln Ser Ala Gly Val Leu Gly 
        675                 680                 685             


Pro Glu Ala Ala Leu Val Asp Val Asn Val Tyr Leu Ile Ile Ala Ile 
    690                 695                 700                 


Cys Ala Val Ser Ser Leu Leu Val Leu Thr Leu Leu Leu Tyr Thr Ala 
705                 710                 715                 720 


Leu Arg Cys Ser Ala Leu Pro Thr Glu Gly Gly Cys Arg Ala Gly Lys 
                725                 730                 735     


Pro Thr Leu Val Cys Ser Ser Ala Val Gly Ser Trp Ser Tyr Ser Gln 
            740                 745                 750         


Gln Gln Pro Gln Arg Val Cys Ser Gly Glu Gly Pro Pro Lys Thr Asp 
        755                 760                 765             


Leu Met Ala Phe Ser Pro Cys Leu Pro Pro Asp Leu Gly Ser Val Asp 
    770                 775                 780                 


Val Gly Glu Glu Gln Asp Leu Asn Val Asp His Gly Leu Lys Val Ser 
785                 790                 795                 800 


Pro Phe Lys Phe Arg Thr His Lys Phe Tyr Leu Trp Lys Leu 
                805                 810                 

<210>  243
<211>  6388
<212>  DNA
<213>  Homo sapiens

<400>  243
ctcgcttttc ttgcaatatt ttataccttt tcaattcata gaattactca agaaaactac     60

ctcagttggt tgctactttt tgttgattcc ttttaccaga catgactaag tttctttttc    120

atcagtagat ttctgggctc ctatattcac tagagattgc aactcctgga tttctcttac    180

actagaatcc tatttcgagc catatgggag attctgaatt ccagaacaaa agaattttgt    240

aatttaaaat tcgtgattgc tcaatggaat cattttaatt gttacttcat ttctgtcgtt    300

atttaaaact taagtggaga gttttctcag ggataagaaa accacaatca aggtcataca    360

aaacttttag aggcagtcag tctgctaaga aggctccagc aagagaaacg ggatcttctg    420

tttcaacaat cattacttaa gaaaaaatta agaaaatgaa ataagttttg cagaataact    480

gtgaaatttt tattcatgaa atatgtactt acactttggg ccacgtgatg tcactctttg    540

ccgcgatgtt ctctctgaat ccagacaaat acagcccttt tcccatggga aagaggctca    600

attctttttc actctctctg tgctgaacga tggcgaacac agcagaatgg gactgacgaa    660

atcagatgat ttcttctaat ttggaggcaa ttttcactaa ttagaagaag actgagtatt    720

tgaaatgtta tactcaagtc gaggagatcc agagggtcag cctctactgc tctcgcttct    780

gatcctcgca atgtgggtgg tggggagcgg ccagctccac tactccgtcc cggaggaagc    840

cgaacacggc accttcgtgg gccgcatcgc gcaggacctg gggctggagc tggcggagct    900

ggtgccgcgc ctgttccagt tggattccaa aggccgcggg gaccttctgg aggtaaatct    960

gcagaatggc attttgtttg tgaattctcg gatcgaccgc gaggagctgt gcgggcggag   1020

cgcggagtgc agcatccacc tggaggtgat cgtagacagg ccgctgcagg ttttccatgt   1080

ggacgtggag gtgaaggaca ttaacgacaa ccctccagtg ttcccagcga cacaaaagaa   1140

tctgttcatc gcggaatcca ggccgcttga ctctcggttt ccactagagg gcgcgtccga   1200

tgcagatatc ggggagaacg ccctgctcac ttacagactg agccccaatg agtatttctt   1260

cctggacgtg ccaaccagca accagcaggt aaaacctctt ggacttgtat tacggaaact   1320

tttagacaga gaagaaactc cggagcttca tttattgctc acggccaccg atggaggcaa   1380

acccgagctg actggcaccg ttcaattact catcacggta ctggacaaca atgacaatgc   1440

cccagtgttc gacagaaccc tgtatacggt gaaattacca gaaaacgttt ctatcggaac   1500

gctggtgatt caccccaatg cctcagattt agacgaaggc ttgaatgggg atattattta   1560

ctccttctcc agtgatgttt ctccagatat aaaatccaag ttccacatgg accccttaag   1620

tggggcaatc acagtgatag gacatatgga ttttgaagaa agtagagcac acaagatccc   1680

agtcgaggct gtcgataaag gcttcccacc cctggctggt cattgtacac ttcttgtgga   1740

agttgtggat gtaaatgaca atgctccaca gttgactatc aaaacgctct cggttcctgt   1800

aaaagaggac gcacaactgg ggacagttat tgccctgatt agtgtgatcg acctagacgc   1860

agatgccaac gggcaggtta cctgctccct gacgccccac gtccccttca agctggtgtc   1920

cacctacaag aattactact cgttggtgct ggacagagct ctggaccgcg agagtgtgtc   1980

cgcctacgag ctggtggtta ccgcgcggga cgggggctcg ccttcactgt gggccacggc   2040

cagggtgtct gtggaggtgg ccgacgtgaa cgacaacgca ccagcgttcg cgcagtccga   2100

gtacacggtg ttcgtgaagg agaacaaccc gccgggctgc cacatcttca cggtgtctgc   2160

gcgggacgct gacgcgcagg agaacgccct ggtgtcctac tcgctggtgg agcggcggtt   2220

gggcgagcgc tcgctgtcga gctacgtgtc agtgcacgcg gagagcggca aggtgtacgc   2280

gctgcagccg ttggaccacg aggagctgga gctgctacag ttccaggtga gcgcgcgcga   2340

cgcgggcgtg ccgcctctgg gcagcaacgt gacgctgcag gtgttcgtgc tggacgagaa   2400

cgacaatgcg ccggcgctgc tgacacctcg gatgaggggc actgacggcg cagtgagcga   2460

gatggtgctg cggtcggtgg gcgccggcgt agtggtgggg aaggtgcgcg cagtggacgc   2520

cgactcgggc tacaacgcgt ggctttcata cgagctgcag ccagaaacgg ccagcgcgag   2580

catcccgttc cgcgtggggc tgtacacggg cgagatcagc acaacgcgtg ccctggacga   2640

aacggacgca ccgcgccagc gcctactggt gctggtgaaa gaccacgggg agccagcgct   2700

gacggccacg gccactgtgc tggtgtcgct ggtggagagc ggccaggcgc caaagtcatc   2760

gtcgcgggcg tcagtgggtg ccacgggccc cgaggtgacg ctggtggatg tcaacgtgta   2820

cctgatcatc gccatctgcg cggtgtctag cctgttggtt ctcacgctgc tgctgtacac   2880

tgtgctgcgg tgctcggcga tgcccaccga gggcgagtgc gcgcctggca agccgacgct   2940

ggtgtgttct agcgcggtgg ggagttggtc gtactcgcag cagaggaggc agagggtgtg   3000

ctctggcgag ggtaagcaga agaccgacct catggccttc agcccgggcc tttctccttg   3060

tgctggatct acagagcgaa cgggagaacc ctctgcttcc tcagattcaa ctgggaaggt   3120

gggtttttct agcattttat ttatttatat aatttttttt cttgaaagat attatcgatt   3180

actcccaggg gccgttcaaa tagttttatt catttttcta gaaatccagc agattttttt   3240

tctgataaag taaacccctt aacattggag ccgactttgt cttgacttct agtgagaatt   3300

ataaactgta tattaaatag atattttttg ggtgctgaat caattttatt taaatttgtg   3360

attaaagtga cattgaattt ctgatgctat gctgccataa cacttgaaaa ccaatttagt   3420

tgttagtcat tcattaaaca ttaacatcac tatcatttat ttattgctaa atgatgcata   3480

gtattttagt ctacttgtat tgtttataag aaacccaagc aaaaatatat agcaattgtt   3540

accttgttaa gtttgtagtt ctctacattt ctctggatgg agactgtgaa catctgattg   3600

ttcagcaacc ttcagtatct attattttaa taagaaagaa acttccccta aactttagaa   3660

aacagttgct ccactttagg aatcaaatta tgtcaataaa tgttataaac acagccttca   3720

tttcaactta tataaaatat gttttaaaat gcctgacaat gtagataatt caagaaatgt   3780

tgactgaaat tttgtctaca cttagaacat tttttgaaat tcagtttaca gaaattggag   3840

aaaatgcttt ttaaacaagt gtttcctttc ttcaagaaga tattctcctt ttaattgaaa   3900

ttttctccat tcagtgataa aatgatcagc catgtgaaga ttcgaaactt cgagttcttt   3960

tgaaattcag agtctgtaac ttaaaacatt acccttatga atttagatga gaattcactt   4020

gttctgtcag taatccataa gacagaaatc tgttttttta aaaatatctt tttctcctct   4080

cagctcatac ataacacaag gcagaaatct ggatatgaga tttgcctctt taatgtcact   4140

acatgttatg tttcctgaat tgtagtatgt gactttcaaa atggtggttt tccacactct   4200

acctttagtg caagctattt gtttgttttc taatttatag ttttaaaaac ttcgcttatt   4260

gagtttttgt tatgtggttt atatttttct ttctctttca gctattttat ttaatattgt   4320

gtcagatatt ttacaaggta tgacctaatt aaaaactcag tagagaaaga tcagaatggc   4380

cttgagaata gagccacaaa aataactatg aaaatgccag taacgtttat ttaaaacaaa   4440

atattttaat ttttaaattt tcccttaaaa cacacttttg gaatatgcta caatattaca   4500

tgttttttgt ctttttattt ttctgagacg gagtcgtttt ctgccaccca ggctggagta   4560

cagtggcatg atcttggctc actgcaacgt ctgcctcctg ggttcaagca attctcctgc   4620

ctcagcctcc tgagtagctg ggattatagg cacatgccac cgcgcccagc taatttttgt   4680

atttttagta gagatggggt ttcatcatgt tggccaggtt ggtctcgaac tcctgacctt   4740

gtgatgctcc cacctcggcc tcccaaagtg ctgggattaa agctgtgagc cactgtgcca   4800

aggctttttt attttttttt tttgtcattt tctttcaaaa cttgagtggt ctctgagctc   4860

ctgtcattaa acctatctat atctgtctat cagcacaact caccttgaat atagtcttat   4920

actttcaagt atctttgtct ttgcacgttt ttcaagtttc atgtgccatt taaacttgga   4980

cccaggtatc tgattatttg atgtgaatag agggatgcta cagatgtcat ttgtctcccg   5040

ccctaagtcc tccagtctcc ttagagctag tacttactaa gcatttacta tgtcatcaat   5100

aatcataaaa cgtatttttt tttttgagtc agagtctcgc tctgttgccc aggctggagt   5160

gcagtggtgc catcttggct cactccaagc tccccctccc gtgttcacgc cattctcctg   5220

cctcagcctc ccgagtagct gggactacag gcgcctgcca ccatgcccgc ctaatttttt   5280

tgtattttta gtagagatgg ggtttcaccg tgttagtcag gatggtctcg atctcctgac   5340

ctcatgatcc tcccgcctca gcctcccaaa atgctgggat tacaggcgtg agccaccgcg   5400

cctggcctaa aatgtgttct ttattattga cggctgtatt gatgggattg gtaatttagt   5460

ccttcatatt aatctctatt ctctctcaga gtacaagctc tcatcatatg caaattctca   5520

gaagggctgt gaacacctta gtaataaatt tatcttttga ggtcattagc aaacatgaac   5580

tcacagggat ccagagatgg taaaattcaa aacagcctgt caagttcaaa acagagaggt   5640

gaaagcagaa gagacacttt cctattttgc ctaataggtc tccttatatg catctgtagt   5700

taacattcct caattcaagt tagaatcatg aaacaataat gaagctcctc ctatgtctct   5760

tttcaagttg taattactat ataggaaaaa ctaagttgtc acccaatatc ttagacactt   5820

tgagagcaaa gggggtgctg taaataagta tacaagatca cagacctaaa ttgagcctgt   5880

tccagacaaa ttggggccta tggtcaacct atccttagac ctgctaacgc attagcatta   5940

gcagcaccta agtcctcatt gaatgttctg gttcaaggct ccacctcaga aattctgaaa   6000

tgggtagtaa gagcaaattt tcattttaaa gcacacctga gatgattctc atacaaccga   6060

aattttagat ccatagccct atttgatact tgacagtgca agtttctgta atttaaaaag   6120

atgtggtggc ctgacacctg caatcccaac attttgggag gccaaggtgg gagggtccct   6180

tccttgagcc cagcagtttg agaccaatgt agtgagactc atctctgcca aaaaaaaaaa   6240

attagccggg catggtggca cacatctcta gtcccaatta ctcaggaggc tgaggcgaga   6300

gaatcgcttg agcctgggac attgaggctg cagtgaactg tgatggcaca actgcatttc   6360

agcccgggag acagcaagat tctgtctc                                      6388


<210>  244
<211>  842
<212>  PRT
<213>  Homo sapiens

<400>  244


Met Leu Tyr Ser Ser Arg Gly Asp Pro Glu Gly Gln Pro Leu Leu Leu 
1               5                   10                  15      


Ser Leu Leu Ile Leu Ala Met Trp Val Val Gly Ser Gly Gln Leu His 
            20                  25                  30          


Tyr Ser Val Pro Glu Glu Ala Glu His Gly Thr Phe Val Gly Arg Ile 
        35                  40                  45              


Ala Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Pro Arg Leu Phe 
    50                  55                  60                  


Gln Leu Asp Ser Lys Gly Arg Gly Asp Leu Leu Glu Val Asn Leu Gln 
65                  70                  75                  80  


Asn Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Gly Arg Ser Ala Glu Cys Ser Ile His Leu Glu Val Ile Val Asp Arg 
            100                 105                 110         


Pro Leu Gln Val Phe His Val Asp Val Glu Val Lys Asp Ile Asn Asp 
        115                 120                 125             


Asn Pro Pro Val Phe Pro Ala Thr Gln Lys Asn Leu Phe Ile Ala Glu 
    130                 135                 140                 


Ser Arg Pro Leu Asp Ser Arg Phe Pro Leu Glu Gly Ala Ser Asp Ala 
145                 150                 155                 160 


Asp Ile Gly Glu Asn Ala Leu Leu Thr Tyr Arg Leu Ser Pro Asn Glu 
                165                 170                 175     


Tyr Phe Phe Leu Asp Val Pro Thr Ser Asn Gln Gln Val Lys Pro Leu 
            180                 185                 190         


Gly Leu Val Leu Arg Lys Leu Leu Asp Arg Glu Glu Thr Pro Glu Leu 
        195                 200                 205             


His Leu Leu Leu Thr Ala Thr Asp Gly Gly Lys Pro Glu Leu Thr Gly 
    210                 215                 220                 


Thr Val Gln Leu Leu Ile Thr Val Leu Asp Asn Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Val Phe Asp Arg Thr Leu Tyr Thr Val Lys Leu Pro Glu Asn Val Ser 
                245                 250                 255     


Ile Gly Thr Leu Val Ile His Pro Asn Ala Ser Asp Leu Asp Glu Gly 
            260                 265                 270         


Leu Asn Gly Asp Ile Ile Tyr Ser Phe Ser Ser Asp Val Ser Pro Asp 
        275                 280                 285             


Ile Lys Ser Lys Phe His Met Asp Pro Leu Ser Gly Ala Ile Thr Val 
    290                 295                 300                 


Ile Gly His Met Asp Phe Glu Glu Ser Arg Ala His Lys Ile Pro Val 
305                 310                 315                 320 


Glu Ala Val Asp Lys Gly Phe Pro Pro Leu Ala Gly His Cys Thr Leu 
                325                 330                 335     


Leu Val Glu Val Val Asp Val Asn Asp Asn Ala Pro Gln Leu Thr Ile 
            340                 345                 350         


Lys Thr Leu Ser Val Pro Val Lys Glu Asp Ala Gln Leu Gly Thr Val 
        355                 360                 365             


Ile Ala Leu Ile Ser Val Ile Asp Leu Asp Ala Asp Ala Asn Gly Gln 
    370                 375                 380                 


Val Thr Cys Ser Leu Thr Pro His Val Pro Phe Lys Leu Val Ser Thr 
385                 390                 395                 400 


Tyr Lys Asn Tyr Tyr Ser Leu Val Leu Asp Arg Ala Leu Asp Arg Glu 
                405                 410                 415     


Ser Val Ser Ala Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser 
            420                 425                 430         


Pro Ser Leu Trp Ala Thr Ala Arg Val Ser Val Glu Val Ala Asp Val 
        435                 440                 445             


Asn Asp Asn Ala Pro Ala Phe Ala Gln Ser Glu Tyr Thr Val Phe Val 
    450                 455                 460                 


Lys Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Arg 
465                 470                 475                 480 


Asp Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu 
                485                 490                 495     


Arg Arg Leu Gly Glu Arg Ser Leu Ser Ser Tyr Val Ser Val His Ala 
            500                 505                 510         


Glu Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu 
        515                 520                 525             


Glu Leu Leu Gln Phe Gln Val Ser Ala Arg Asp Ala Gly Val Pro Pro 
    530                 535                 540                 


Leu Gly Ser Asn Val Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp 
545                 550                 555                 560 


Asn Ala Pro Ala Leu Leu Thr Pro Arg Met Arg Gly Thr Asp Gly Ala 
                565                 570                 575     


Val Ser Glu Met Val Leu Arg Ser Val Gly Ala Gly Val Val Val Gly 
            580                 585                 590         


Lys Val Arg Ala Val Asp Ala Asp Ser Gly Tyr Asn Ala Trp Leu Ser 
        595                 600                 605             


Tyr Glu Leu Gln Pro Glu Thr Ala Ser Ala Ser Ile Pro Phe Arg Val 
    610                 615                 620                 


Gly Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Ala Leu Asp Glu Thr 
625                 630                 635                 640 


Asp Ala Pro Arg Gln Arg Leu Leu Val Leu Val Lys Asp His Gly Glu 
                645                 650                 655     


Pro Ala Leu Thr Ala Thr Ala Thr Val Leu Val Ser Leu Val Glu Ser 
            660                 665                 670         


Gly Gln Ala Pro Lys Ser Ser Ser Arg Ala Ser Val Gly Ala Thr Gly 
        675                 680                 685             


Pro Glu Val Thr Leu Val Asp Val Asn Val Tyr Leu Ile Ile Ala Ile 
    690                 695                 700                 


Cys Ala Val Ser Ser Leu Leu Val Leu Thr Leu Leu Leu Tyr Thr Val 
705                 710                 715                 720 


Leu Arg Cys Ser Ala Met Pro Thr Glu Gly Glu Cys Ala Pro Gly Lys 
                725                 730                 735     


Pro Thr Leu Val Cys Ser Ser Ala Val Gly Ser Trp Ser Tyr Ser Gln 
            740                 745                 750         


Gln Arg Arg Gln Arg Val Cys Ser Gly Glu Gly Lys Gln Lys Thr Asp 
        755                 760                 765             


Leu Met Ala Phe Ser Pro Gly Leu Ser Pro Cys Ala Gly Ser Thr Glu 
    770                 775                 780                 


Arg Thr Gly Glu Pro Ser Ala Ser Ser Asp Ser Thr Gly Lys Val Gly 
785                 790                 795                 800 


Phe Ser Ser Ile Leu Phe Ile Tyr Ile Ile Phe Phe Leu Glu Arg Tyr 
                805                 810                 815     


Tyr Arg Leu Leu Pro Gly Ala Val Gln Ile Val Leu Phe Ile Phe Leu 
            820                 825                 830         


Glu Ile Gln Gln Ile Phe Phe Leu Ile Lys 
        835                 840         

<210>  245
<211>  5984
<212>  DNA
<213>  Homo sapiens

<400>  245
ctcgcttttc ttgcaatatt ttataccttt tcaattcata gaattactca agaaaactac     60

ctcagttggt tgctactttt tgttgattcc ttttaccaga catgactaag tttctttttc    120

atcagtagat ttctgggctc ctatattcac tagagattgc aactcctgga tttctcttac    180

actagaatcc tatttcgagc catatgggag attctgaatt ccagaacaaa agaattttgt    240

aatttaaaat tcgtgattgc tcaatggaat cattttaatt gttacttcat ttctgtcgtt    300

atttaaaact taagtggaga gttttctcag ggataagaaa accacaatca aggtcataca    360

aaacttttag aggcagtcag tctgctaaga aggctccagc aagagaaacg ggatcttctg    420

tttcaacaat cattacttaa gaaaaaatta agaaaatgaa ataagttttg cagaataact    480

gtgaaatttt tattcatgaa atatgtactt acactttggg ccacgtgatg tcactctttg    540

ccgcgatgtt ctctctgaat ccagacaaat acagcccttt tcccatggga aagaggctca    600

attctttttc actctctctg tgctgaacga tggcgaacac agcagaatgg gactgacgaa    660

atcagatgat ttcttctaat ttggaggcaa ttttcactaa ttagaagaag actgagtatt    720

tgaaatgtta tactcaagtc gaggagatcc agagggtcag cctctactgc tctcgcttct    780

gatcctcgca atgtgggtgg tggggagcgg ccagctccac tactccgtcc cggaggaagc    840

cgaacacggc accttcgtgg gccgcatcgc gcaggacctg gggctggagc tggcggagct    900

ggtgccgcgc ctgttccagt tggattccaa aggccgcggg gaccttctgg aggtaaatct    960

gcagaatggc attttgtttg tgaattctcg gatcgaccgc gaggagctgt gcgggcggag   1020

cgcggagtgc agcatccacc tggaggtgat cgtagacagg ccgctgcagg ttttccatgt   1080

ggacgtggag gtgaaggaca ttaacgacaa ccctccagtg ttcccagcga cacaaaagaa   1140

tctgttcatc gcggaatcca ggccgcttga ctctcggttt ccactagagg gcgcgtccga   1200

tgcagatatc ggggagaacg ccctgctcac ttacagactg agccccaatg agtatttctt   1260

cctggacgtg ccaaccagca accagcaggt aaaacctctt ggacttgtat tacggaaact   1320

tttagacaga gaagaaactc cggagcttca tttattgctc acggccaccg atggaggcaa   1380

acccgagctg actggcaccg ttcaattact catcacggta ctggacaaca atgacaatgc   1440

cccagtgttc gacagaaccc tgtatacggt gaaattacca gaaaacgttt ctatcggaac   1500

gctggtgatt caccccaatg cctcagattt agacgaaggc ttgaatgggg atattattta   1560

ctccttctcc agtgatgttt ctccagatat aaaatccaag ttccacatgg accccttaag   1620

tggggcaatc acagtgatag gacatatgga ttttgaagaa agtagagcac acaagatccc   1680

agtcgaggct gtcgataaag gcttcccacc cctggctggt cattgtacac ttcttgtgga   1740

agttgtggat gtaaatgaca atgctccaca gttgactatc aaaacgctct cggttcctgt   1800

aaaagaggac gcacaactgg ggacagttat tgccctgatt agtgtgatcg acctagacgc   1860

agatgccaac gggcaggtta cctgctccct gacgccccac gtccccttca agctggtgtc   1920

cacctacaag aattactact cgttggtgct ggacagagct ctggaccgcg agagtgtgtc   1980

cgcctacgag ctggtggtta ccgcgcggga cgggggctcg ccttcactgt gggccacggc   2040

cagggtgtct gtggaggtgg ccgacgtgaa cgacaacgca ccagcgttcg cgcagtccga   2100

gtacacggtg ttcgtgaagg agaacaaccc gccgggctgc cacatcttca cggtgtctgc   2160

gcgggacgct gacgcgcagg agaacgccct ggtgtcctac tcgctggtgg agcggcggtt   2220

gggcgagcgc tcgctgtcga gctacgtgtc agtgcacgcg gagagcggca aggtgtacgc   2280

gctgcagccg ttggaccacg aggagctgga gctgctacag ttccaggtga gcgcgcgcga   2340

cgcgggcgtg ccgcctctgg gcagcaacgt gacgctgcag gtgttcgtgc tggacgagaa   2400

cgacaatgcg ccggcgctgc tgacacctcg gatgaggggc actgacggcg cagtgagcga   2460

gatggtgctg cggtcggtgg gcgccggcgt agtggtgggg aaggtgcgcg cagtggacgc   2520

cgactcgggc tacaacgcgt ggctttcata cgagctgcag ccagaaacgg ccagcgcgag   2580

catcccgttc cgcgtggggc tgtacacggg cgagatcagc acaacgcgtg ccctggacga   2640

aacggacgca ccgcgccagc gcctactggt gctggtgaaa gaccacgggg agccagcgct   2700

gacggccacg gccactgtgc tggtgtcgct ggtggagagc ggccaggcgc caaagtcatc   2760

gtcgcgggcg tcagtgggtg ccacgggccc cgaggtgacg ctggtggatg tcaacgtgta   2820

cctgatcatc gccatctgcg cggtgtctag cctgttggtt ctcacgctgc tgctgtacac   2880

tgtgctgcgg tgctcggcga tgcccaccga gggcgagtgc gcgcctggca agccgacgct   2940

ggtgtgttct agcgcggtgg ggagttggtc gtactcgcag cagaggaggc agagggtgtg   3000

ctctggcgag ggtaagcaga agaccgacct catggccttc agcccgggcc tttctccttg   3060

tgctggatct acagagcgaa cgggagaacc ctctgcttcc tcagattcaa ctgggaagcc   3120

acgacagccc aaccctgact ggcgttactc tgcctccctg agagcaggca tgcacagctc   3180

tgtgcaccta gaggaggctg gcattctacg ggctggtcca ggagggcctg atcagcagtg   3240

gccaacagta tccagtgcaa caccagaacc agaggcagga gaagtgtccc ctccagtcgg   3300

tgcgggtgtc aacagcaaca gctggacctt taaatacgga ccaggcaacc ccaaacaatc   3360

cggtcccggt gagttgcccg acaaattcat tatcccagga tctcctgcaa tcatctccat   3420

ccggcaggag cctactaaca gccaaattga caaaagtgac ttcataacct tcggcaaaaa   3480

ggaggagacc aagaaaaaga agaaaaagaa gaagggtaac aagacccagg agaaaaaaga   3540

gaaagggaac agcacgactg acaacagtga ccagtgaggt cctcaaatgg aaacaagcca   3600

cttagccagt ttttgtaata atggcaaatc tctcccatgt agcaattccc tgctcctttt   3660

tcctatctac atgagccctc ttagagacct cagaaatctg cagaaagttc cctgtgtctg   3720

tctagaacgc atttaacagg ttttgtcgta aaagctttac taagtctggt gttaactctt   3780

tctctccact ctggcttgtt ttcagaacct aaaaagcaga cccaagtttc ctttctcctc   3840

cgccgcaaag gagaggcttc ccagccccgc cagtgagagg ttggactctc tgccctgtgc   3900

tccggggatc ctgtcttgat gacacttgca gggcaggctg aaaagttttg agattgagca   3960

gcttgggagt ttgtggccac tgggtatgtg tggctaccgc gggtatgcga gtgccagata   4020

ttggctgaga cgagccagct tagactaatt ggtacaagga aggcaagaaa acaaagacaa   4080

ataaacagcg gaagttatca gtatggaggg gaagtgtaaa cttaaaggga ccagactttc   4140

taaatcttac aactcaagag gtggcagcca ccctctagga gacaaaacta cccccactga   4200

caaggcttta ggagacccta aagtctgttg gctgtgacgt cattatacct aaaatctgca   4260

tcatacctgc aagccaacag ttcagtgttt taacagagaa ccaccctggg aaacagaagc   4320

agatctgatg tgtttcctat acatgtcctg tgctcacttt attaaaaatt cttttgcaca   4380

caatgtttat gaaaaggcca gatccttttc caatacttat gcaaaagcaa aagaaaaccc   4440

cgacacctca cctttcgctg tttgttgttt catagattta tttaaaaaaa gagaaagtct   4500

atagctataa atctttaaag agaaatatga atacaattcc cctaaactct cctcaaaaga   4560

gaattcagtc tacagccatt taaatgatca ttgctgctac agaagtgctt taagagaatt   4620

gcctgaaaca tctgtattat atcggccacc tgccaatcac agctttactc tttcaggtca   4680

ctctggggct gcctcttgca tgtattacta aataaaatga tctctctttc tctctctctc   4740

tctcttttct aagaaacaat tatgtgcact ttgatacaca accttctcta accaactata   4800

tatcaagacc caaaaattga agaaaaatat tgttttctca tacagtgagc agatttttca   4860

atctactaat tctgtgactt gtcttggtgt gctagcctac accttctctt tggtttagtt   4920

ttccttttct ataacactct gaattgctaa tcttactaac acctatgatg ttacctgaaa   4980

tcaatctccc atatgtatgc tgtatgctat gctaagactc ctgaaatata cttactctgt   5040

gcttgtgtat gtgaatgtta atgcaactat tacctagagt gaactttaag ctttattgtt   5100

gaatgtaatt ccattatatt tccttttgta cacctgtgaa aaagtggagt agtgtttttt   5160

taaccattgt taatcagctt ttgtgtatga aagacacagt aaaatttctt tcttaaatca   5220

agatactggt gattcaagga attttattta tggtccagcc aagagccatc tcgtgccaag   5280

acttctgctg gcaagggaat ggataaagct gttttgttct agtaacaatt ttggaatgaa   5340

tactgacaat attccatgag ggtgtgcaag cacaaatttt accaatctga cctctttgaa   5400

gttgcagaat gctttgaaat tctaatggta tctgaaatat cagctcatag aaagtaacaa   5460

aatttgctgt caccttaaat aagacatttt aattttgtta taatgtacaa tttagaagtt   5520

tgattaatta tattatctat ttaggcatta atataaaaga ggtaggagtc tgttatttaa   5580

aaaaagcatt aaatttaaaa aaaaactgtc ttgtctactt ttagcttcat tctcccatat   5640

tttgaagggt gtgtaacttc agctctgcag gattgcatgg ggtaaaactt gttaccaaca   5700

catgtgaacc attgctacat tgtaggttgt gatcattttg ccccactgaa gcccatgtat   5760

ctgaccttac gtgccttttg aactaggaga atcgggctaa tttattaatg atgataatta   5820

taatgtatct gtacagcact ttttacattt gcgaagtgct ttccaatcca tgttagttac   5880

tagttattac agctgtaagg ataaaacacg tcatgtggat tcattttgaa ttggtgctat   5940

tggtatttcc tctgttattg ctaataaatg aaaatggtgg tatg                    5984


<210>  246
<211>  950
<212>  PRT
<213>  Homo sapiens

<400>  246


Met Leu Tyr Ser Ser Arg Gly Asp Pro Glu Gly Gln Pro Leu Leu Leu 
1               5                   10                  15      


Ser Leu Leu Ile Leu Ala Met Trp Val Val Gly Ser Gly Gln Leu His 
            20                  25                  30          


Tyr Ser Val Pro Glu Glu Ala Glu His Gly Thr Phe Val Gly Arg Ile 
        35                  40                  45              


Ala Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Pro Arg Leu Phe 
    50                  55                  60                  


Gln Leu Asp Ser Lys Gly Arg Gly Asp Leu Leu Glu Val Asn Leu Gln 
65                  70                  75                  80  


Asn Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Gly Arg Ser Ala Glu Cys Ser Ile His Leu Glu Val Ile Val Asp Arg 
            100                 105                 110         


Pro Leu Gln Val Phe His Val Asp Val Glu Val Lys Asp Ile Asn Asp 
        115                 120                 125             


Asn Pro Pro Val Phe Pro Ala Thr Gln Lys Asn Leu Phe Ile Ala Glu 
    130                 135                 140                 


Ser Arg Pro Leu Asp Ser Arg Phe Pro Leu Glu Gly Ala Ser Asp Ala 
145                 150                 155                 160 


Asp Ile Gly Glu Asn Ala Leu Leu Thr Tyr Arg Leu Ser Pro Asn Glu 
                165                 170                 175     


Tyr Phe Phe Leu Asp Val Pro Thr Ser Asn Gln Gln Val Lys Pro Leu 
            180                 185                 190         


Gly Leu Val Leu Arg Lys Leu Leu Asp Arg Glu Glu Thr Pro Glu Leu 
        195                 200                 205             


His Leu Leu Leu Thr Ala Thr Asp Gly Gly Lys Pro Glu Leu Thr Gly 
    210                 215                 220                 


Thr Val Gln Leu Leu Ile Thr Val Leu Asp Asn Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Val Phe Asp Arg Thr Leu Tyr Thr Val Lys Leu Pro Glu Asn Val Ser 
                245                 250                 255     


Ile Gly Thr Leu Val Ile His Pro Asn Ala Ser Asp Leu Asp Glu Gly 
            260                 265                 270         


Leu Asn Gly Asp Ile Ile Tyr Ser Phe Ser Ser Asp Val Ser Pro Asp 
        275                 280                 285             


Ile Lys Ser Lys Phe His Met Asp Pro Leu Ser Gly Ala Ile Thr Val 
    290                 295                 300                 


Ile Gly His Met Asp Phe Glu Glu Ser Arg Ala His Lys Ile Pro Val 
305                 310                 315                 320 


Glu Ala Val Asp Lys Gly Phe Pro Pro Leu Ala Gly His Cys Thr Leu 
                325                 330                 335     


Leu Val Glu Val Val Asp Val Asn Asp Asn Ala Pro Gln Leu Thr Ile 
            340                 345                 350         


Lys Thr Leu Ser Val Pro Val Lys Glu Asp Ala Gln Leu Gly Thr Val 
        355                 360                 365             


Ile Ala Leu Ile Ser Val Ile Asp Leu Asp Ala Asp Ala Asn Gly Gln 
    370                 375                 380                 


Val Thr Cys Ser Leu Thr Pro His Val Pro Phe Lys Leu Val Ser Thr 
385                 390                 395                 400 


Tyr Lys Asn Tyr Tyr Ser Leu Val Leu Asp Arg Ala Leu Asp Arg Glu 
                405                 410                 415     


Ser Val Ser Ala Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser 
            420                 425                 430         


Pro Ser Leu Trp Ala Thr Ala Arg Val Ser Val Glu Val Ala Asp Val 
        435                 440                 445             


Asn Asp Asn Ala Pro Ala Phe Ala Gln Ser Glu Tyr Thr Val Phe Val 
    450                 455                 460                 


Lys Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Arg 
465                 470                 475                 480 


Asp Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu 
                485                 490                 495     


Arg Arg Leu Gly Glu Arg Ser Leu Ser Ser Tyr Val Ser Val His Ala 
            500                 505                 510         


Glu Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu 
        515                 520                 525             


Glu Leu Leu Gln Phe Gln Val Ser Ala Arg Asp Ala Gly Val Pro Pro 
    530                 535                 540                 


Leu Gly Ser Asn Val Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp 
545                 550                 555                 560 


Asn Ala Pro Ala Leu Leu Thr Pro Arg Met Arg Gly Thr Asp Gly Ala 
                565                 570                 575     


Val Ser Glu Met Val Leu Arg Ser Val Gly Ala Gly Val Val Val Gly 
            580                 585                 590         


Lys Val Arg Ala Val Asp Ala Asp Ser Gly Tyr Asn Ala Trp Leu Ser 
        595                 600                 605             


Tyr Glu Leu Gln Pro Glu Thr Ala Ser Ala Ser Ile Pro Phe Arg Val 
    610                 615                 620                 


Gly Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Ala Leu Asp Glu Thr 
625                 630                 635                 640 


Asp Ala Pro Arg Gln Arg Leu Leu Val Leu Val Lys Asp His Gly Glu 
                645                 650                 655     


Pro Ala Leu Thr Ala Thr Ala Thr Val Leu Val Ser Leu Val Glu Ser 
            660                 665                 670         


Gly Gln Ala Pro Lys Ser Ser Ser Arg Ala Ser Val Gly Ala Thr Gly 
        675                 680                 685             


Pro Glu Val Thr Leu Val Asp Val Asn Val Tyr Leu Ile Ile Ala Ile 
    690                 695                 700                 


Cys Ala Val Ser Ser Leu Leu Val Leu Thr Leu Leu Leu Tyr Thr Val 
705                 710                 715                 720 


Leu Arg Cys Ser Ala Met Pro Thr Glu Gly Glu Cys Ala Pro Gly Lys 
                725                 730                 735     


Pro Thr Leu Val Cys Ser Ser Ala Val Gly Ser Trp Ser Tyr Ser Gln 
            740                 745                 750         


Gln Arg Arg Gln Arg Val Cys Ser Gly Glu Gly Lys Gln Lys Thr Asp 
        755                 760                 765             


Leu Met Ala Phe Ser Pro Gly Leu Ser Pro Cys Ala Gly Ser Thr Glu 
    770                 775                 780                 


Arg Thr Gly Glu Pro Ser Ala Ser Ser Asp Ser Thr Gly Lys Pro Arg 
785                 790                 795                 800 


Gln Pro Asn Pro Asp Trp Arg Tyr Ser Ala Ser Leu Arg Ala Gly Met 
                805                 810                 815     


His Ser Ser Val His Leu Glu Glu Ala Gly Ile Leu Arg Ala Gly Pro 
            820                 825                 830         


Gly Gly Pro Asp Gln Gln Trp Pro Thr Val Ser Ser Ala Thr Pro Glu 
        835                 840                 845             


Pro Glu Ala Gly Glu Val Ser Pro Pro Val Gly Ala Gly Val Asn Ser 
    850                 855                 860                 


Asn Ser Trp Thr Phe Lys Tyr Gly Pro Gly Asn Pro Lys Gln Ser Gly 
865                 870                 875                 880 


Pro Gly Glu Leu Pro Asp Lys Phe Ile Ile Pro Gly Ser Pro Ala Ile 
                885                 890                 895     


Ile Ser Ile Arg Gln Glu Pro Thr Asn Ser Gln Ile Asp Lys Ser Asp 
            900                 905                 910         


Phe Ile Thr Phe Gly Lys Lys Glu Glu Thr Lys Lys Lys Lys Lys Lys 
        915                 920                 925             


Lys Lys Gly Asn Lys Thr Gln Glu Lys Lys Glu Lys Gly Asn Ser Thr 
    930                 935                 940                 


Thr Asp Asn Ser Asp Gln 
945                 950 

<210>  247
<211>  5254
<212>  DNA
<213>  Homo sapiens

<400>  247
atggtttcca gatgtagctg cctgggggtc cagtgtctgc tgctctcgct tcttctcctc     60

gcagcctggg aggtggggag cggccagctc cactactcag tctacgagga ggccagacac    120

ggcaccttcg tgggccgcat cgcgcaggac ctggggctgg agctggcgga gctggtgcag    180

cgcctgttcc gggtggcgtc caaaagacac ggggaccttc tggaggtaaa tctgcagaat    240

ggcattttgt ttgtgaattc tcggattgac cgcgaggagc tgtgcgggcg gagcgtggag    300

tgcagcatcc acctggaggt gatcgtggac aggccgctgc aggttttcca tgtggacgtg    360

gaagtgaagg acattaacga caacccgccc aggttctccg taacagaaca aaagctctca    420

atacctgaat ccagactgct tgactctcga tttccactag aaggcgcatc tgatgcggat    480

gttggagaga acgcattgct tacttacaaa ctcagtccaa atgagtattt tgttcttgat    540

attataaaca aaaaagacaa agacaaattc ccagtgcttg ttctgcggaa gctgctggat    600

cgtgaagaaa atcctcagct aaagttgttg ttgacagcaa ctgatggagg caaacctgaa    660

tttaccggat ctgtttctct gctgatcctg gtgttagatg ccaatgataa cgcccctatc    720

tttgacagac cggtttatga agttaagatg tatgaaaatc aagtgaacca aacattagta    780

atacggctca acgcttctga ttcggatgaa ggaataaaca aggaaatgat gtattcattt    840

agctctttgg tcccacccac gataagaagg aaattttgga taaacgaaag gacgggagaa    900

ataaaagtaa atgatgctat tgactttgag gacagtaaca cttatgaaat tcatgtagat    960

gttacagata agggaaaccc acctatggtt ggtcactgca cggtcctagt ggaactactg   1020

gatgaaaatg ataattcacc tgaggtgatt gtcacttctc tgtctctccc agtgaaagaa   1080

gatgctcaag tgggcaccgt cattgcccta atcagcgttt ctgaccatga ttcaggagcc   1140

aacggacagg tcacctgctc tctgacgcct cacgttccgt tcaagctggt gtccacctac   1200

aagaattact actcattggt gctggacagc gctctggacc gcgagagggt gtcggcctat   1260

gagctggtgg tgaccgcgcg ggacgggggc tcgcctccgc tgtgggccac ggccagcgtg   1320

tctgtggagg tggccgacgt gaacgacaac gcgcctgcgt tcgcgcagtc cgagtacacg   1380

gtgttcgtga aggagaacaa cccgccaggc tgccacatct tcacggtgtc tgcgtgggac   1440

gcggacgcgc aggagaacgc cctggtgtcc tactctctgg tggagcggcg gttgggcgag   1500

cgctcgctgt cgagctacgt gtcggtgcac gcggagagcg gcaaggtgta cgcgctgcag   1560

ccgctggacc acgaggagct ggagctgcta cagttccagg tgagcgcgcg cgatgggggc   1620

gtgccgcctc tgggcagcaa cttgacgctg caggtgttcg tgctggacga gaacgacaac   1680

gctcccgcgc tgctggcgtc tcccgctggc agcgcgggcg gtgcagtcag tgagctggtg   1740

ctgcggtcgg tggttgcggg tcacgtggtg gctaaggtgc gcgcagtgga cgctgactct   1800

ggatacaacg cgtggctgtc gtatgaattg cagtcggcgg cggttggtgc acgcatcccg   1860

tttcgcgtgg ggctgtacac gggcgagatc agtacgacgc gcgctctgga tgagactgac   1920

tcgccacgcc agcgcctact ggtgctggtg aaggaccatg gcgagccgtc gctgacggcc   1980

acggccactg tgcttgtgtc gcttgtggag ggcagccagg cacccaaggc ctcgtcgcgg   2040

gcttcagtgg gcgtggcgcc cgaggtggcc ctggtggatg tcaacgtgta cctgatcatc   2100

gccatctgcg cggtgtccag cttgctggtg ctcacgctgc tgctgtacac tgcactgagg   2160

tgctcggcgg cgcccaccga gggcgcatgt gggccggtga agcccacgct ggtgtgctct   2220

agcgcggtgg ggagctggtc ttactcgcag cagaggcggc agagggtgtg ttctggggag   2280

ggcctgccca aggcggacct catggccttc agccccagcc ttccaccatg cccaatggta   2340

gatgtggacg gggaagatca gtctattgga ggggaccact ctaggaagcc acgacagccc   2400

aaccctgact ggcgttactc tgcctccctg agagcaggca tgcacagctc tgtgcaccta   2460

gaggaggctg gcattctacg ggctggtcca ggagggcctg atcagcagtg gccaacagta   2520

tccagtgcaa caccagaacc agaggcagga gaagtgtccc ctccagtcgg tgcgggtgtc   2580

aacagcaaca gctggacctt taaatacgga ccaggcaacc ccaaacaatc cggtcccggt   2640

gagttgcccg acaaattcat tatcccagga tctcctgcaa tcatctccat ccggcaggag   2700

cctactaaca gccaaattga caaaagtgac ttcataacct tcggcaaaaa ggaggagacc   2760

aagaaaaaga agaaaaagaa gaagggtaac aagacccagg agaaaaaaga gaaagggaac   2820

agcacgactg acaacagtga ccagtgaggt cctcaaatgg aaacaagcca cttagccagt   2880

ttttgtaata atggcaaatc tctcccatgt agcaattccc tgctcctttt tcctatctac   2940

atgagccctc ttagagacct cagaaatctg cagaaagttc cctgtgtctg tctagaacgc   3000

atttaacagg ttttgtcgta aaagctttac taagtctggt gttaactctt tctctccact   3060

ctggcttgtt ttcagaacct aaaaagcaga cccaagtttc ctttctcctc cgccgcaaag   3120

gagaggcttc ccagccccgc cagtgagagg ttggactctc tgccctgtgc tccggggatc   3180

ctgtcttgat gacacttgca gggcaggctg aaaagttttg agattgagca gcttgggagt   3240

ttgtggccac tgggtatgtg tggctaccgc gggtatgcga gtgccagata ttggctgaga   3300

cgagccagct tagactaatt ggtacaagga aggcaagaaa acaaagacaa ataaacagcg   3360

gaagttatca gtatggaggg gaagtgtaaa cttaaaggga ccagactttc taaatcttac   3420

aactcaagag gtggcagcca ccctctagga gacaaaacta cccccactga caaggcttta   3480

ggagacccta aagtctgttg gctgtgacgt cattatacct aaaatctgca tcatacctgc   3540

aagccaacag ttcagtgttt taacagagaa ccaccctggg aaacagaagc agatctgatg   3600

tgtttcctat acatgtcctg tgctcacttt attaaaaatt cttttgcaca caatgtttat   3660

gaaaaggcca gatccttttc caatacttat gcaaaagcaa aagaaaaccc cgacacctca   3720

cctttcgctg tttgttgttt catagattta tttaaaaaaa gagaaagtct atagctataa   3780

atctttaaag agaaatatga atacaattcc cctaaactct cctcaaaaga gaattcagtc   3840

tacagccatt taaatgatca ttgctgctac agaagtgctt taagagaatt gcctgaaaca   3900

tctgtattat atcggccacc tgccaatcac agctttactc tttcaggtca ctctggggct   3960

gcctcttgca tgtattacta aataaaatga tctctctttc tctctctctc tctcttttct   4020

aagaaacaat tatgtgcact ttgatacaca accttctcta accaactata tatcaagacc   4080

caaaaattga agaaaaatat tgttttctca tacagtgagc agatttttca atctactaat   4140

tctgtgactt gtcttggtgt gctagcctac accttctctt tggtttagtt ttccttttct   4200

ataacactct gaattgctaa tcttactaac acctatgatg ttacctgaaa tcaatctccc   4260

atatgtatgc tgtatgctat gctaagactc ctgaaatata cttactctgt gcttgtgtat   4320

gtgaatgtta atgcaactat tacctagagt gaactttaag ctttattgtt gaatgtaatt   4380

ccattatatt tccttttgta cacctgtgaa aaagtggagt agtgtttttt taaccattgt   4440

taatcagctt ttgtgtatga aagacacagt aaaatttctt tcttaaatca agatactggt   4500

gattcaagga attttattta tggtccagcc aagagccatc tcgtgccaag acttctgctg   4560

gcaagggaat ggataaagct gttttgttct agtaacaatt ttggaatgaa tactgacaat   4620

attccatgag ggtgtgcaag cacaaatttt accaatctga cctctttgaa gttgcagaat   4680

gctttgaaat tctaatggta tctgaaatat cagctcatag aaagtaacaa aatttgctgt   4740

caccttaaat aagacatttt aattttgtta taatgtacaa tttagaagtt tgattaatta   4800

tattatctat ttaggcatta atataaaaga ggtaggagtc tgttatttaa aaaaagcatt   4860

aaatttaaaa aaaaactgtc ttgtctactt ttagcttcat tctcccatat tttgaagggt   4920

gtgtaacttc agctctgcag gattgcatgg ggtaaaactt gttaccaaca catgtgaacc   4980

attgctacat tgtaggttgt gatcattttg ccccactgaa gcccatgtat ctgaccttac   5040

gtgccttttg aactaggaga atcgggctaa tttattaatg atgataatta taatgtatct   5100

gtacagcact ttttacattt gcgaagtgct ttccaatcca tgttagttac tagttattac   5160

agctgtaagg ataaaacacg tcatgtggat tcattttgaa ttggtgctat tggtatttcc   5220

tctgttattg ctaataaatg aaaatggtgg tatg                               5254


<210>  248
<211>  948
<212>  PRT
<213>  Homo sapiens

<400>  248


Met Val Ser Arg Cys Ser Cys Leu Gly Val Gln Cys Leu Leu Leu Ser 
1               5                   10                  15      


Leu Leu Leu Leu Ala Ala Trp Glu Val Gly Ser Gly Gln Leu His Tyr 
            20                  25                  30          


Ser Val Tyr Glu Glu Ala Arg His Gly Thr Phe Val Gly Arg Ile Ala 
        35                  40                  45              


Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Gln Arg Leu Phe Arg 
    50                  55                  60                  


Val Ala Ser Lys Arg His Gly Asp Leu Leu Glu Val Asn Leu Gln Asn 
65                  70                  75                  80  


Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys Gly 
                85                  90                  95      


Arg Ser Val Glu Cys Ser Ile His Leu Glu Val Ile Val Asp Arg Pro 
            100                 105                 110         


Leu Gln Val Phe His Val Asp Val Glu Val Lys Asp Ile Asn Asp Asn 
        115                 120                 125             


Pro Pro Arg Phe Ser Val Thr Glu Gln Lys Leu Ser Ile Pro Glu Ser 
    130                 135                 140                 


Arg Leu Leu Asp Ser Arg Phe Pro Leu Glu Gly Ala Ser Asp Ala Asp 
145                 150                 155                 160 


Val Gly Glu Asn Ala Leu Leu Thr Tyr Lys Leu Ser Pro Asn Glu Tyr 
                165                 170                 175     


Phe Val Leu Asp Ile Ile Asn Lys Lys Asp Lys Asp Lys Phe Pro Val 
            180                 185                 190         


Leu Val Leu Arg Lys Leu Leu Asp Arg Glu Glu Asn Pro Gln Leu Lys 
        195                 200                 205             


Leu Leu Leu Thr Ala Thr Asp Gly Gly Lys Pro Glu Phe Thr Gly Ser 
    210                 215                 220                 


Val Ser Leu Leu Ile Leu Val Leu Asp Ala Asn Asp Asn Ala Pro Ile 
225                 230                 235                 240 


Phe Asp Arg Pro Val Tyr Glu Val Lys Met Tyr Glu Asn Gln Val Asn 
                245                 250                 255     


Gln Thr Leu Val Ile Arg Leu Asn Ala Ser Asp Ser Asp Glu Gly Ile 
            260                 265                 270         


Asn Lys Glu Met Met Tyr Ser Phe Ser Ser Leu Val Pro Pro Thr Ile 
        275                 280                 285             


Arg Arg Lys Phe Trp Ile Asn Glu Arg Thr Gly Glu Ile Lys Val Asn 
    290                 295                 300                 


Asp Ala Ile Asp Phe Glu Asp Ser Asn Thr Tyr Glu Ile His Val Asp 
305                 310                 315                 320 


Val Thr Asp Lys Gly Asn Pro Pro Met Val Gly His Cys Thr Val Leu 
                325                 330                 335     


Val Glu Leu Leu Asp Glu Asn Asp Asn Ser Pro Glu Val Ile Val Thr 
            340                 345                 350         


Ser Leu Ser Leu Pro Val Lys Glu Asp Ala Gln Val Gly Thr Val Ile 
        355                 360                 365             


Ala Leu Ile Ser Val Ser Asp His Asp Ser Gly Ala Asn Gly Gln Val 
    370                 375                 380                 


Thr Cys Ser Leu Thr Pro His Val Pro Phe Lys Leu Val Ser Thr Tyr 
385                 390                 395                 400 


Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu Arg 
                405                 410                 415     


Val Ser Ala Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser Pro 
            420                 425                 430         


Pro Leu Trp Ala Thr Ala Ser Val Ser Val Glu Val Ala Asp Val Asn 
        435                 440                 445             


Asp Asn Ala Pro Ala Phe Ala Gln Ser Glu Tyr Thr Val Phe Val Lys 
    450                 455                 460                 


Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Trp Asp 
465                 470                 475                 480 


Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu Arg 
                485                 490                 495     


Arg Leu Gly Glu Arg Ser Leu Ser Ser Tyr Val Ser Val His Ala Glu 
            500                 505                 510         


Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu Glu 
        515                 520                 525             


Leu Leu Gln Phe Gln Val Ser Ala Arg Asp Gly Gly Val Pro Pro Leu 
    530                 535                 540                 


Gly Ser Asn Leu Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp Asn 
545                 550                 555                 560 


Ala Pro Ala Leu Leu Ala Ser Pro Ala Gly Ser Ala Gly Gly Ala Val 
                565                 570                 575     


Ser Glu Leu Val Leu Arg Ser Val Val Ala Gly His Val Val Ala Lys 
            580                 585                 590         


Val Arg Ala Val Asp Ala Asp Ser Gly Tyr Asn Ala Trp Leu Ser Tyr 
        595                 600                 605             


Glu Leu Gln Ser Ala Ala Val Gly Ala Arg Ile Pro Phe Arg Val Gly 
    610                 615                 620                 


Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Ala Leu Asp Glu Thr Asp 
625                 630                 635                 640 


Ser Pro Arg Gln Arg Leu Leu Val Leu Val Lys Asp His Gly Glu Pro 
                645                 650                 655     


Ser Leu Thr Ala Thr Ala Thr Val Leu Val Ser Leu Val Glu Gly Ser 
            660                 665                 670         


Gln Ala Pro Lys Ala Ser Ser Arg Ala Ser Val Gly Val Ala Pro Glu 
        675                 680                 685             


Val Ala Leu Val Asp Val Asn Val Tyr Leu Ile Ile Ala Ile Cys Ala 
    690                 695                 700                 


Val Ser Ser Leu Leu Val Leu Thr Leu Leu Leu Tyr Thr Ala Leu Arg 
705                 710                 715                 720 


Cys Ser Ala Ala Pro Thr Glu Gly Ala Cys Gly Pro Val Lys Pro Thr 
                725                 730                 735     


Leu Val Cys Ser Ser Ala Val Gly Ser Trp Ser Tyr Ser Gln Gln Arg 
            740                 745                 750         


Arg Gln Arg Val Cys Ser Gly Glu Gly Leu Pro Lys Ala Asp Leu Met 
        755                 760                 765             


Ala Phe Ser Pro Ser Leu Pro Pro Cys Pro Met Val Asp Val Asp Gly 
    770                 775                 780                 


Glu Asp Gln Ser Ile Gly Gly Asp His Ser Arg Lys Pro Arg Gln Pro 
785                 790                 795                 800 


Asn Pro Asp Trp Arg Tyr Ser Ala Ser Leu Arg Ala Gly Met His Ser 
                805                 810                 815     


Ser Val His Leu Glu Glu Ala Gly Ile Leu Arg Ala Gly Pro Gly Gly 
            820                 825                 830         


Pro Asp Gln Gln Trp Pro Thr Val Ser Ser Ala Thr Pro Glu Pro Glu 
        835                 840                 845             


Ala Gly Glu Val Ser Pro Pro Val Gly Ala Gly Val Asn Ser Asn Ser 
    850                 855                 860                 


Trp Thr Phe Lys Tyr Gly Pro Gly Asn Pro Lys Gln Ser Gly Pro Gly 
865                 870                 875                 880 


Glu Leu Pro Asp Lys Phe Ile Ile Pro Gly Ser Pro Ala Ile Ile Ser 
                885                 890                 895     


Ile Arg Gln Glu Pro Thr Asn Ser Gln Ile Asp Lys Ser Asp Phe Ile 
            900                 905                 910         


Thr Phe Gly Lys Lys Glu Glu Thr Lys Lys Lys Lys Lys Lys Lys Lys 
        915                 920                 925             


Gly Asn Lys Thr Gln Glu Lys Lys Glu Lys Gly Asn Ser Thr Thr Asp 
    930                 935                 940                 


Asn Ser Asp Gln 
945             

<210>  249
<211>  2535
<212>  DNA
<213>  Homo sapiens

<400>  249
atggtttcca gatgtagctg cctgggggtc cagtgtctgc tgctctcgct tcttctcctc     60

gcagcctggg aggtggggag cggccagctc cactactcag tctacgagga ggccagacac    120

ggcaccttcg tgggccgcat cgcgcaggac ctggggctgg agctggcgga gctggtgcag    180

cgcctgttcc gggtggcgtc caaaagacac ggggaccttc tggaggtaaa tctgcagaat    240

ggcattttgt ttgtgaattc tcggattgac cgcgaggagc tgtgcgggcg gagcgtggag    300

tgcagcatcc acctggaggt gatcgtggac aggccgctgc aggttttcca tgtggacgtg    360

gaagtgaagg acattaacga caacccgccc aggttctccg taacagaaca aaagctctca    420

atacctgaat ccagactgct tgactctcga tttccactag aaggcgcatc tgatgcggat    480

gttggagaga acgcattgct tacttacaaa ctcagtccaa atgagtattt tgttcttgat    540

attataaaca aaaaagacaa agacaaattc ccagtgcttg ttctgcggaa gctgctggat    600

cgtgaagaaa atcctcagct aaagttgttg ttgacagcaa ctgatggagg caaacctgaa    660

tttaccggat ctgtttctct gctgatcctg gtgttagatg ccaatgataa cgcccctatc    720

tttgacagac cggtttatga agttaagatg tatgaaaatc aagtgaacca aacattagta    780

atacggctca acgcttctga ttcggatgaa ggaataaaca aggaaatgat gtattcattt    840

agctctttgg tcccacccac gataagaagg aaattttgga taaacgaaag gacgggagaa    900

ataaaagtaa atgatgctat tgactttgag gacagtaaca cttatgaaat tcatgtagat    960

gttacagata agggaaaccc acctatggtt ggtcactgca cggtcctagt ggaactactg   1020

gatgaaaatg ataattcacc tgaggtgatt gtcacttctc tgtctctccc agtgaaagaa   1080

gatgctcaag tgggcaccgt cattgcccta atcagcgttt ctgaccatga ttcaggagcc   1140

aacggacagg tcacctgctc tctgacgcct cacgttccgt tcaagctggt gtccacctac   1200

aagaattact actcattggt gctggacagc gctctggacc gcgagagggt gtcggcctat   1260

gagctggtgg tgaccgcgcg ggacgggggc tcgcctccgc tgtgggccac ggccagcgtg   1320

tctgtggagg tggccgacgt gaacgacaac gcgcctgcgt tcgcgcagtc cgagtacacg   1380

gtgttcgtga aggagaacaa cccgccaggc tgccacatct tcacggtgtc tgcgtgggac   1440

gcggacgcgc aggagaacgc cctggtgtcc tactctctgg tggagcggcg gttgggcgag   1500

cgctcgctgt cgagctacgt gtcggtgcac gcggagagcg gcaaggtgta cgcgctgcag   1560

ccgctggacc acgaggagct ggagctgcta cagttccagg tgagcgcgcg cgatgggggc   1620

gtgccgcctc tgggcagcaa cttgacgctg caggtgttcg tgctggacga gaacgacaac   1680

gctcccgcgc tgctggcgtc tcccgctggc agcgcgggcg gtgcagtcag tgagctggtg   1740

ctgcggtcgg tggttgcggg tcacgtggtg gctaaggtgc gcgcagtgga cgctgactct   1800

ggatacaacg cgtggctgtc gtatgaattg cagtcggcgg cggttggtgc acgcatcccg   1860

tttcgcgtgg ggctgtacac gggcgagatc agtacgacgc gcgctctgga tgagactgac   1920

tcgccacgcc agcgcctact ggtgctggtg aaggaccatg gcgagccgtc gctgacggcc   1980

acggccactg tgcttgtgtc gcttgtggag ggcagccagg cacccaaggc ctcgtcgcgg   2040

gcttcagtgg gcgtggcgcc cgaggtggcc ctggtggatg tcaacgtgta cctgatcatc   2100

gccatctgcg cggtgtccag cttgctggtg ctcacgctgc tgctgtacac tgcactgagg   2160

tgctcggcgg cgcccaccga gggcgcatgt gggccggtga agcccacgct ggtgtgctct   2220

agcgcggtgg ggagctggtc ttactcgcag cagaggcggc agagggtgtg ttctggggag   2280

ggcctgccca aggcggacct catggccttc agccccagcc ttccaccatg cccaatggta   2340

gatgtggacg gggaagatca gtctattgga ggggaccact ctaggaaggt gggttattac   2400

gttttcattt tccttttgtg ctttatgaat aatattttct cttaccgcat tttctcaaat   2460

atgtatcaga atatttcatt tttgtctaca ttccatttat gcttgaatat ttctagtgat   2520

acctttgtaa tataa                                                    2535


<210>  250
<211>  844
<212>  PRT
<213>  Homo sapiens

<400>  250


Met Val Ser Arg Cys Ser Cys Leu Gly Val Gln Cys Leu Leu Leu Ser 
1               5                   10                  15      


Leu Leu Leu Leu Ala Ala Trp Glu Val Gly Ser Gly Gln Leu His Tyr 
            20                  25                  30          


Ser Val Tyr Glu Glu Ala Arg His Gly Thr Phe Val Gly Arg Ile Ala 
        35                  40                  45              


Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Gln Arg Leu Phe Arg 
    50                  55                  60                  


Val Ala Ser Lys Arg His Gly Asp Leu Leu Glu Val Asn Leu Gln Asn 
65                  70                  75                  80  


Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys Gly 
                85                  90                  95      


Arg Ser Val Glu Cys Ser Ile His Leu Glu Val Ile Val Asp Arg Pro 
            100                 105                 110         


Leu Gln Val Phe His Val Asp Val Glu Val Lys Asp Ile Asn Asp Asn 
        115                 120                 125             


Pro Pro Arg Phe Ser Val Thr Glu Gln Lys Leu Ser Ile Pro Glu Ser 
    130                 135                 140                 


Arg Leu Leu Asp Ser Arg Phe Pro Leu Glu Gly Ala Ser Asp Ala Asp 
145                 150                 155                 160 


Val Gly Glu Asn Ala Leu Leu Thr Tyr Lys Leu Ser Pro Asn Glu Tyr 
                165                 170                 175     


Phe Val Leu Asp Ile Ile Asn Lys Lys Asp Lys Asp Lys Phe Pro Val 
            180                 185                 190         


Leu Val Leu Arg Lys Leu Leu Asp Arg Glu Glu Asn Pro Gln Leu Lys 
        195                 200                 205             


Leu Leu Leu Thr Ala Thr Asp Gly Gly Lys Pro Glu Phe Thr Gly Ser 
    210                 215                 220                 


Val Ser Leu Leu Ile Leu Val Leu Asp Ala Asn Asp Asn Ala Pro Ile 
225                 230                 235                 240 


Phe Asp Arg Pro Val Tyr Glu Val Lys Met Tyr Glu Asn Gln Val Asn 
                245                 250                 255     


Gln Thr Leu Val Ile Arg Leu Asn Ala Ser Asp Ser Asp Glu Gly Ile 
            260                 265                 270         


Asn Lys Glu Met Met Tyr Ser Phe Ser Ser Leu Val Pro Pro Thr Ile 
        275                 280                 285             


Arg Arg Lys Phe Trp Ile Asn Glu Arg Thr Gly Glu Ile Lys Val Asn 
    290                 295                 300                 


Asp Ala Ile Asp Phe Glu Asp Ser Asn Thr Tyr Glu Ile His Val Asp 
305                 310                 315                 320 


Val Thr Asp Lys Gly Asn Pro Pro Met Val Gly His Cys Thr Val Leu 
                325                 330                 335     


Val Glu Leu Leu Asp Glu Asn Asp Asn Ser Pro Glu Val Ile Val Thr 
            340                 345                 350         


Ser Leu Ser Leu Pro Val Lys Glu Asp Ala Gln Val Gly Thr Val Ile 
        355                 360                 365             


Ala Leu Ile Ser Val Ser Asp His Asp Ser Gly Ala Asn Gly Gln Val 
    370                 375                 380                 


Thr Cys Ser Leu Thr Pro His Val Pro Phe Lys Leu Val Ser Thr Tyr 
385                 390                 395                 400 


Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu Arg 
                405                 410                 415     


Val Ser Ala Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser Pro 
            420                 425                 430         


Pro Leu Trp Ala Thr Ala Ser Val Ser Val Glu Val Ala Asp Val Asn 
        435                 440                 445             


Asp Asn Ala Pro Ala Phe Ala Gln Ser Glu Tyr Thr Val Phe Val Lys 
    450                 455                 460                 


Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Trp Asp 
465                 470                 475                 480 


Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu Arg 
                485                 490                 495     


Arg Leu Gly Glu Arg Ser Leu Ser Ser Tyr Val Ser Val His Ala Glu 
            500                 505                 510         


Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu Glu 
        515                 520                 525             


Leu Leu Gln Phe Gln Val Ser Ala Arg Asp Gly Gly Val Pro Pro Leu 
    530                 535                 540                 


Gly Ser Asn Leu Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp Asn 
545                 550                 555                 560 


Ala Pro Ala Leu Leu Ala Ser Pro Ala Gly Ser Ala Gly Gly Ala Val 
                565                 570                 575     


Ser Glu Leu Val Leu Arg Ser Val Val Ala Gly His Val Val Ala Lys 
            580                 585                 590         


Val Arg Ala Val Asp Ala Asp Ser Gly Tyr Asn Ala Trp Leu Ser Tyr 
        595                 600                 605             


Glu Leu Gln Ser Ala Ala Val Gly Ala Arg Ile Pro Phe Arg Val Gly 
    610                 615                 620                 


Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Ala Leu Asp Glu Thr Asp 
625                 630                 635                 640 


Ser Pro Arg Gln Arg Leu Leu Val Leu Val Lys Asp His Gly Glu Pro 
                645                 650                 655     


Ser Leu Thr Ala Thr Ala Thr Val Leu Val Ser Leu Val Glu Gly Ser 
            660                 665                 670         


Gln Ala Pro Lys Ala Ser Ser Arg Ala Ser Val Gly Val Ala Pro Glu 
        675                 680                 685             


Val Ala Leu Val Asp Val Asn Val Tyr Leu Ile Ile Ala Ile Cys Ala 
    690                 695                 700                 


Val Ser Ser Leu Leu Val Leu Thr Leu Leu Leu Tyr Thr Ala Leu Arg 
705                 710                 715                 720 


Cys Ser Ala Ala Pro Thr Glu Gly Ala Cys Gly Pro Val Lys Pro Thr 
                725                 730                 735     


Leu Val Cys Ser Ser Ala Val Gly Ser Trp Ser Tyr Ser Gln Gln Arg 
            740                 745                 750         


Arg Gln Arg Val Cys Ser Gly Glu Gly Leu Pro Lys Ala Asp Leu Met 
        755                 760                 765             


Ala Phe Ser Pro Ser Leu Pro Pro Cys Pro Met Val Asp Val Asp Gly 
    770                 775                 780                 


Glu Asp Gln Ser Ile Gly Gly Asp His Ser Arg Lys Val Gly Tyr Tyr 
785                 790                 795                 800 


Val Phe Ile Phe Leu Leu Cys Phe Met Asn Asn Ile Phe Ser Tyr Arg 
                805                 810                 815     


Ile Phe Ser Asn Met Tyr Gln Asn Ile Ser Phe Leu Ser Thr Phe His 
            820                 825                 830         


Leu Cys Leu Asn Ile Ser Ser Asp Thr Phe Val Ile 
        835                 840                 

<210>  251
<211>  4465
<212>  DNA
<213>  Homo sapiens

<400>  251
atggtttcca gatgtagctg cctgggggtc cagtgtctgc tgctctcgct tcttctcctc     60

gcagcctggg aggtggggag cggccagctc cactactcag tctacgagga ggccagacac    120

ggcaccttcg tgggccgcat cgcgcaggac ctggggctgg agctggcgga gctggtgcag    180

cgcctgttcc gggtggcgtc caaaagacac ggggaccttc tggaggtaaa tctgcagaat    240

ggcattttgt ttgtgaattc tcggattgac cgcgaggagc tgtgcgggcg gagcgtggag    300

tgcagcatcc acctggaggt gatcgtggac aggccgctgc aggttttcca tgtggacgtg    360

gaagtgaagg acattaacga caacccgccc aggttctccg taacagaaca aaagctctca    420

atacctgaat ccagactgct tgactctcga tttccactag aaggcgcatc tgatgcggat    480

gttggagaga acgcattgct tacttacaaa ctcagtccaa atgagtattt tgttcttgat    540

attataaaca aaaaagacaa agacaaattc ccagtgcttg ttctgcggaa gctgctggat    600

cgtgaagaaa atcctcagct aaagttgttg ttgacagcaa ctgatggagg caaacctgaa    660

tttaccggat ctgtttctct gctgatcctg gtgttagatg ccaatgataa cgcccctatc    720

tttgacagac cggtttatga agttaagatg tatgaaaatc aagtgaacca aacattagta    780

atacggctca acgcttctga ttcggatgaa ggaataaaca aggaaatgat gtattcattt    840

agctctttgg tcccacccac gataagaagg aaattttgga taaacgaaag gacgggagaa    900

ataaaagtaa atgatgctat tgactttgag gacagtaaca cttatgaaat tcatgtagat    960

gttacagata agggaaaccc acctatggtt ggtcactgca cggtcctagt ggaactactg   1020

gatgaaaatg ataattcacc tgaggtgatt gtcacttctc tgtctctccc agtgaaagaa   1080

gatgctcaag tgggcaccgt cattgcccta atcagcgttt ctgaccatga ttcaggagcc   1140

aacggacagg tcacctgctc tctgacgcct cacgttccgt tcaagctggt gtccacctac   1200

aagaattact actcattggt gctggacagc gctctggacc gcgagagggt gtcggcctat   1260

gagctggtgg tgaccgcgcg ggacgggggc tcgcctccgc tgtgggccac ggccagcgtg   1320

tctgtggagg tggccgacgt gaacgacaac gcgcctgcgt tcgcgcagtc cgagtacacg   1380

gtgttcgtga aggagaacaa cccgccaggc tgccacatct tcacggtgtc tgcgtgggac   1440

gcggacgcgc aggagaacgc cctggtgtcc tactctctgg tggagcggcg gttgggcgag   1500

cgctcgctgt cgagctacgt gtcggtgcac gcggagagcg gcaaggtgta cgcgctgcag   1560

ccgctggacc acgaggagct ggagctgcta cagttccagc cacgacagcc caaccctgac   1620

tggcgttact ctgcctccct gagagcaggc atgcacagct ctgtgcacct agaggaggct   1680

ggcattctac gggctggtcc aggagggcct gatcagcagt ggccaacagt atccagtgca   1740

acaccagaac cagaggcagg agaagtgtcc cctccagtcg gtgcgggtgt caacagcaac   1800

agctggacct ttaaatacgg accaggcaac cccaaacaat ccggtcccgg tgagttgccc   1860

gacaaattca ttatcccagg atctcctgca atcatctcca tccggcagga gcctactaac   1920

agccaaattg acaaaagtga cttcataacc ttcggcaaaa aggaggagac caagaaaaag   1980

aagaaaaaga agaagggtaa caagacccag gagaaaaaag agaaagggaa cagcacgact   2040

gacaacagtg accagtgagg tcctcaaatg gaaacaagcc acttagccag tttttgtaat   2100

aatggcaaat ctctcccatg tagcaattcc ctgctccttt ttcctatcta catgagccct   2160

cttagagacc tcagaaatct gcagaaagtt ccctgtgtct gtctagaacg catttaacag   2220

gttttgtcgt aaaagcttta ctaagtctgg tgttaactct ttctctccac tctggcttgt   2280

tttcagaacc taaaaagcag acccaagttt cctttctcct ccgccgcaaa ggagaggctt   2340

cccagccccg ccagtgagag gttggactct ctgccctgtg ctccggggat cctgtcttga   2400

tgacacttgc agggcaggct gaaaagtttt gagattgagc agcttgggag tttgtggcca   2460

ctgggtatgt gtggctaccg cgggtatgcg agtgccagat attggctgag acgagccagc   2520

ttagactaat tggtacaagg aaggcaagaa aacaaagaca aataaacagc ggaagttatc   2580

agtatggagg ggaagtgtaa acttaaaggg accagacttt ctaaatctta caactcaaga   2640

ggtggcagcc accctctagg agacaaaact acccccactg acaaggcttt aggagaccct   2700

aaagtctgtt ggctgtgacg tcattatacc taaaatctgc atcatacctg caagccaaca   2760

gttcagtgtt ttaacagaga accaccctgg gaaacagaag cagatctgat gtgtttccta   2820

tacatgtcct gtgctcactt tattaaaaat tcttttgcac acaatgttta tgaaaaggcc   2880

agatcctttt ccaatactta tgcaaaagca aaagaaaacc ccgacacctc acctttcgct   2940

gtttgttgtt tcatagattt atttaaaaaa agagaaagtc tatagctata aatctttaaa   3000

gagaaatatg aatacaattc ccctaaactc tcctcaaaag agaattcagt ctacagccat   3060

ttaaatgatc attgctgcta cagaagtgct ttaagagaat tgcctgaaac atctgtatta   3120

tatcggccac ctgccaatca cagctttact ctttcaggtc actctggggc tgcctcttgc   3180

atgtattact aaataaaatg atctctcttt ctctctctct ctctcttttc taagaaacaa   3240

ttatgtgcac tttgatacac aaccttctct aaccaactat atatcaagac ccaaaaattg   3300

aagaaaaata ttgttttctc atacagtgag cagatttttc aatctactaa ttctgtgact   3360

tgtcttggtg tgctagccta caccttctct ttggtttagt tttccttttc tataacactc   3420

tgaattgcta atcttactaa cacctatgat gttacctgaa atcaatctcc catatgtatg   3480

ctgtatgcta tgctaagact cctgaaatat acttactctg tgcttgtgta tgtgaatgtt   3540

aatgcaacta ttacctagag tgaactttaa gctttattgt tgaatgtaat tccattatat   3600

ttccttttgt acacctgtga aaaagtggag tagtgttttt ttaaccattg ttaatcagct   3660

tttgtgtatg aaagacacag taaaatttct ttcttaaatc aagatactgg tgattcaagg   3720

aattttattt atggtccagc caagagccat ctcgtgccaa gacttctgct ggcaagggaa   3780

tggataaagc tgttttgttc tagtaacaat tttggaatga atactgacaa tattccatga   3840

gggtgtgcaa gcacaaattt taccaatctg acctctttga agttgcagaa tgctttgaaa   3900

ttctaatggt atctgaaata tcagctcata gaaagtaaca aaatttgctg tcaccttaaa   3960

taagacattt taattttgtt ataatgtaca atttagaagt ttgattaatt atattatcta   4020

tttaggcatt aatataaaag aggtaggagt ctgttattta aaaaaagcat taaatttaaa   4080

aaaaaactgt cttgtctact tttagcttca ttctcccata ttttgaaggg tgtgtaactt   4140

cagctctgca ggattgcatg gggtaaaact tgttaccaac acatgtgaac cattgctaca   4200

ttgtaggttg tgatcatttt gccccactga agcccatgta tctgacctta cgtgcctttt   4260

gaactaggag aatcgggcta atttattaat gatgataatt ataatgtatc tgtacagcac   4320

tttttacatt tgcgaagtgc tttccaatcc atgttagtta ctagttatta cagctgtaag   4380

gataaaacac gtcatgtgga ttcattttga attggtgcta ttggtatttc ctctgttatt   4440

gctaataaat gaaaatggtg gtatg                                         4465


<210>  252
<211>  685
<212>  PRT
<213>  Homo sapiens

<400>  252


Met Val Ser Arg Cys Ser Cys Leu Gly Val Gln Cys Leu Leu Leu Ser 
1               5                   10                  15      


Leu Leu Leu Leu Ala Ala Trp Glu Val Gly Ser Gly Gln Leu His Tyr 
            20                  25                  30          


Ser Val Tyr Glu Glu Ala Arg His Gly Thr Phe Val Gly Arg Ile Ala 
        35                  40                  45              


Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Gln Arg Leu Phe Arg 
    50                  55                  60                  


Val Ala Ser Lys Arg His Gly Asp Leu Leu Glu Val Asn Leu Gln Asn 
65                  70                  75                  80  


Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys Gly 
                85                  90                  95      


Arg Ser Val Glu Cys Ser Ile His Leu Glu Val Ile Val Asp Arg Pro 
            100                 105                 110         


Leu Gln Val Phe His Val Asp Val Glu Val Lys Asp Ile Asn Asp Asn 
        115                 120                 125             


Pro Pro Arg Phe Ser Val Thr Glu Gln Lys Leu Ser Ile Pro Glu Ser 
    130                 135                 140                 


Arg Leu Leu Asp Ser Arg Phe Pro Leu Glu Gly Ala Ser Asp Ala Asp 
145                 150                 155                 160 


Val Gly Glu Asn Ala Leu Leu Thr Tyr Lys Leu Ser Pro Asn Glu Tyr 
                165                 170                 175     


Phe Val Leu Asp Ile Ile Asn Lys Lys Asp Lys Asp Lys Phe Pro Val 
            180                 185                 190         


Leu Val Leu Arg Lys Leu Leu Asp Arg Glu Glu Asn Pro Gln Leu Lys 
        195                 200                 205             


Leu Leu Leu Thr Ala Thr Asp Gly Gly Lys Pro Glu Phe Thr Gly Ser 
    210                 215                 220                 


Val Ser Leu Leu Ile Leu Val Leu Asp Ala Asn Asp Asn Ala Pro Ile 
225                 230                 235                 240 


Phe Asp Arg Pro Val Tyr Glu Val Lys Met Tyr Glu Asn Gln Val Asn 
                245                 250                 255     


Gln Thr Leu Val Ile Arg Leu Asn Ala Ser Asp Ser Asp Glu Gly Ile 
            260                 265                 270         


Asn Lys Glu Met Met Tyr Ser Phe Ser Ser Leu Val Pro Pro Thr Ile 
        275                 280                 285             


Arg Arg Lys Phe Trp Ile Asn Glu Arg Thr Gly Glu Ile Lys Val Asn 
    290                 295                 300                 


Asp Ala Ile Asp Phe Glu Asp Ser Asn Thr Tyr Glu Ile His Val Asp 
305                 310                 315                 320 


Val Thr Asp Lys Gly Asn Pro Pro Met Val Gly His Cys Thr Val Leu 
                325                 330                 335     


Val Glu Leu Leu Asp Glu Asn Asp Asn Ser Pro Glu Val Ile Val Thr 
            340                 345                 350         


Ser Leu Ser Leu Pro Val Lys Glu Asp Ala Gln Val Gly Thr Val Ile 
        355                 360                 365             


Ala Leu Ile Ser Val Ser Asp His Asp Ser Gly Ala Asn Gly Gln Val 
    370                 375                 380                 


Thr Cys Ser Leu Thr Pro His Val Pro Phe Lys Leu Val Ser Thr Tyr 
385                 390                 395                 400 


Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu Arg 
                405                 410                 415     


Val Ser Ala Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser Pro 
            420                 425                 430         


Pro Leu Trp Ala Thr Ala Ser Val Ser Val Glu Val Ala Asp Val Asn 
        435                 440                 445             


Asp Asn Ala Pro Ala Phe Ala Gln Ser Glu Tyr Thr Val Phe Val Lys 
    450                 455                 460                 


Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Trp Asp 
465                 470                 475                 480 


Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu Arg 
                485                 490                 495     


Arg Leu Gly Glu Arg Ser Leu Ser Ser Tyr Val Ser Val His Ala Glu 
            500                 505                 510         


Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu Glu 
        515                 520                 525             


Leu Leu Gln Phe Gln Pro Arg Gln Pro Asn Pro Asp Trp Arg Tyr Ser 
    530                 535                 540                 


Ala Ser Leu Arg Ala Gly Met His Ser Ser Val His Leu Glu Glu Ala 
545                 550                 555                 560 


Gly Ile Leu Arg Ala Gly Pro Gly Gly Pro Asp Gln Gln Trp Pro Thr 
                565                 570                 575     


Val Ser Ser Ala Thr Pro Glu Pro Glu Ala Gly Glu Val Ser Pro Pro 
            580                 585                 590         


Val Gly Ala Gly Val Asn Ser Asn Ser Trp Thr Phe Lys Tyr Gly Pro 
        595                 600                 605             


Gly Asn Pro Lys Gln Ser Gly Pro Gly Glu Leu Pro Asp Lys Phe Ile 
    610                 615                 620                 


Ile Pro Gly Ser Pro Ala Ile Ile Ser Ile Arg Gln Glu Pro Thr Asn 
625                 630                 635                 640 


Ser Gln Ile Asp Lys Ser Asp Phe Ile Thr Phe Gly Lys Lys Glu Glu 
                645                 650                 655     


Thr Lys Lys Lys Lys Lys Lys Lys Lys Gly Asn Lys Thr Gln Glu Lys 
            660                 665                 670         


Lys Glu Lys Gly Asn Ser Thr Thr Asp Asn Ser Asp Gln 
        675                 680                 685 

<210>  253
<211>  6115
<212>  DNA
<213>  Homo sapiens

<400>  253
ttttcctttg tggattcttt tttaaaacta ccaagtttga gaatatgaat atatttgttt     60

ttcatattgt tctgcaatga atataaagtc acttataatc agaaagcaat taaatgtaaa    120

taacagtaaa gaatgagaac tatagaaaat agatatgaaa atgcaagccc acagagatga    180

gaatagatca tgtggaacat aaacactaaa gagctgcttt tataaaactt caattttttc    240

tttgagttcc ctagcagcca aagtaacaag ggagactgaa agtaaaacaa ttcaaatttg    300

atagtatttt tatatgagga acaacacttt caggaaatgt ttaaccctag tttttcatga    360

ggccacctta acaactgaat tctctttctc tctcactctg tgtataagta ttttagataa    420

gtaaaagaac aatgttataa tgttaagtca aacatagaca caataattta aatttgatgt    480

taatcgagaa atacaatgcc atttccatat atatttagtt tcaatatgac ttataatctg    540

aatattccat aaataagcac gttggaaata tttgggggaa gaaacccaaa acacgtgaaa    600

ttctgtggtg gtaaatgcag tgcacagtac tcacagtttt aggcgcaagg tgtcgctctt    660

tacttggtgg aaagttcatt taaaggttgg tctgaacagt gaggcactcc catacaaagg    720

aactccatca taccggatgc caccgtttaa ggatcctttg aaacttctta agaattcaac    780

gagattttta acctgaaact gaagaatctg gtactgtaag tgtaaagaag cttattttgg    840

aagccaattt cgtatgcgat gtttggtttt cagagaaggg gattgggcac cccacgacta    900

cagctctggc ttctcctcct cgaattctgg gaggtgggga gcggccagct ccactactcc    960

gtctcggagg aggccaaaca cggcaccttc gtgggccgca tcgcgcagga cctggggctg   1020

gagctggcgg agctggtgca gcgcctgttc cgggtggcgt ccaaaacaca tggggacctt   1080

ctggaggtaa atctgcagaa tggcattttg tttgtgaatt ctcggatcga ccgcgaggag   1140

ctgtgcgggc agagcgcgga gtgcagcatc cacctggagg tgatcgtgga caggccgctg   1200

caggttttcc atgtgaacgt ggaggtgaag gacattaacg acaacccgcc ggtgttctcg   1260

ctcagagaac aaaagctgct gattgcggaa tctaagcaat cggactcgcg ttttccacta   1320

gagggagctt ctgatgctga cattgaagag aatgctctat tgacctacag gctaagtaaa   1380

aatgagtatt tttctttaga ttcaccaaca aatggtaagc agattaaaag actgtcactt   1440

attttaaaga agtctctgga tagagagaaa actccggaac ttaatttgct gctaacagct   1500

acagacgggg gaaaaccaga gcttactggc accgttcggc tgttagtcca agtcttggat   1560

gtcaacgaca atgatccaga gtttgataaa tcagaatata aggtgagcct tatggaaaat   1620

gctgctaaag aaactcttgt gctcaaacta aacgccacag accgagacga aggagtcaat   1680

ggagaggtaa catactcctt aatgtcaatt aagcccaatg gaagacactt atttacacta   1740

gatcaaaata atggagaagt gagggtcaat ggaactttag attatgaaga aaacaagttt   1800

tataaaattg aagtacaggc tacagataag gggactcccc caatggcagg tcactgtaca   1860

gtctgggtgg aaatcttgga caccaacgat aactctcctg aagtcgccgt gacttccttg   1920

tccctcccag tacgagagga cgctcagccc agcacggtca ttgccctgat cagcgtgtct   1980

gaccgtgact caggtgtcaa cggacaggtg acctgctcgc tgacgcccca cgttcccttc   2040

aagctggtgt ccaccttcaa gaattactac tcgttggtgc tggacagcgc cctggaccgc   2100

gagaacgtgt gggcctatga actggtggtg actgcgcggg atgggggttc gccttctctg   2160

tgggccacgg ccagggtatc cgtggaggtg gccgacgtga acgacaatgc gcctgcgttc   2220

gcacagcccg agtacaccgt gttcgtgaag gagaacaacc caccaggctg ccacatcttc   2280

acagtgtcgg cgcgggacgc ggacgcgcag gagaacgcgc tggtgtccta ctcgctggtg   2340

gagcggcggt tgggcgaccg cgcgctgtcg agctacgtgt cggtgcacgc ggagagcggc   2400

aaggtgtacg cgctgcagcc gttggaccac gaggagctgg agctgctaca gttccaggtg   2460

agcgcgcgcg atgcgggcgt gccgcctctg agcagcaacg tgacgctgca ggtgttcgtg   2520

ctggacgaga acgacaacgc gccggcactg ctggcgactc aggctggcag cgcgggaggc   2580

gcagttaaca agctagtacc gcggtcggtg ggtgcgggcc acgtggtggc gaaggtgcgc   2640

gcagtggatg cggactcagg ctacaacgcg tggctttcat atgaattgca gccggcggcg   2700

ggcggctcgc gcatcccgtt ccgcgtgggg ctgtacacgg gcgagataag cacaacgcgt   2760

gccctggacg aggcagactc gccgcgccac cgacttctag tactggtgaa ggatcacggt   2820

gagccggcgc tgacggccac ggccaccgtg ctggtgtcgt tggtggagag cggacaggcg   2880

ccaaaggcct cttcccggac tttggcgggc gccgcgagcc cagaggctgc gctggtggat   2940

gtcaacgtgt acctgatcat cgccatctgc gtggtgtcca gcctcctggt actcacgctg   3000

ctgctgtata cggcgctgtg gtggtcggca acgcccactg agggcgcgtg cgcgccgggg   3060

aagcccacgc tggtgtgctc ccgcgcggtg gggagctggt catactcgca gcagaggcgg   3120

cagagggtgt gctctgagga gggcccacct aagacggacc tcatggcctt cagccccagt   3180

cttcctctag gtctgaataa agaggaggaa ggggaaagac aggagccagg gtcaaatcac   3240

cccggacagc cacgacagcc caaccctgac tggcgttact ctgcctccct gagagcaggc   3300

atgcacagct ctgtgcacct agaggaggct ggcattctac gggctggtcc aggagggcct   3360

gatcagcagt ggccaacagt atccagtgca acaccagaac cagaggcagg agaagtgtcc   3420

cctccagtcg gtgcgggtgt caacagcaac agctggacct ttaaatacgg accaggcaac   3480

cccaaacaat ccggtcccgg tgagttgccc gacaaattca ttatcccagg atctcctgca   3540

atcatctcca tccggcagga gcctactaac agccaaattg acaaaagtga cttcataacc   3600

ttcggcaaaa aggaggagac caagaaaaag aagaaaaaga agaagggtaa caagacccag   3660

gagaaaaaag agaaagggaa cagcacgact gacaacagtg accagtgagg tcctcaaatg   3720

gaaacaagcc acttagccag tttttgtaat aatggcaaat ctctcccatg tagcaattcc   3780

ctgctccttt ttcctatcta catgagccct cttagagacc tcagaaatct gcagaaagtt   3840

ccctgtgtct gtctagaacg catttaacag gttttgtcgt aaaagcttta ctaagtctgg   3900

tgttaactct ttctctccac tctggcttgt tttcagaacc taaaaagcag acccaagttt   3960

cctttctcct ccgccgcaaa ggagaggctt cccagccccg ccagtgagag gttggactct   4020

ctgccctgtg ctccggggat cctgtcttga tgacacttgc agggcaggct gaaaagtttt   4080

gagattgagc agcttgggag tttgtggcca ctgggtatgt gtggctaccg cgggtatgcg   4140

agtgccagat attggctgag acgagccagc ttagactaat tggtacaagg aaggcaagaa   4200

aacaaagaca aataaacagc ggaagttatc agtatggagg ggaagtgtaa acttaaaggg   4260

accagacttt ctaaatctta caactcaaga ggtggcagcc accctctagg agacaaaact   4320

acccccactg acaaggcttt aggagaccct aaagtctgtt ggctgtgacg tcattatacc   4380

taaaatctgc atcatacctg caagccaaca gttcagtgtt ttaacagaga accaccctgg   4440

gaaacagaag cagatctgat gtgtttccta tacatgtcct gtgctcactt tattaaaaat   4500

tcttttgcac acaatgttta tgaaaaggcc agatcctttt ccaatactta tgcaaaagca   4560

aaagaaaacc ccgacacctc acctttcgct gtttgttgtt tcatagattt atttaaaaaa   4620

agagaaagtc tatagctata aatctttaaa gagaaatatg aatacaattc ccctaaactc   4680

tcctcaaaag agaattcagt ctacagccat ttaaatgatc attgctgcta cagaagtgct   4740

ttaagagaat tgcctgaaac atctgtatta tatcggccac ctgccaatca cagctttact   4800

ctttcaggtc actctggggc tgcctcttgc atgtattact aaataaaatg atctctcttt   4860

ctctctctct ctctcttttc taagaaacaa ttatgtgcac tttgatacac aaccttctct   4920

aaccaactat atatcaagac ccaaaaattg aagaaaaata ttgttttctc atacagtgag   4980

cagatttttc aatctactaa ttctgtgact tgtcttggtg tgctagccta caccttctct   5040

ttggtttagt tttccttttc tataacactc tgaattgcta atcttactaa cacctatgat   5100

gttacctgaa atcaatctcc catatgtatg ctgtatgcta tgctaagact cctgaaatat   5160

acttactctg tgcttgtgta tgtgaatgtt aatgcaacta ttacctagag tgaactttaa   5220

gctttattgt tgaatgtaat tccattatat ttccttttgt acacctgtga aaaagtggag   5280

tagtgttttt ttaaccattg ttaatcagct tttgtgtatg aaagacacag taaaatttct   5340

ttcttaaatc aagatactgg tgattcaagg aattttattt atggtccagc caagagccat   5400

ctcgtgccaa gacttctgct ggcaagggaa tggataaagc tgttttgttc tagtaacaat   5460

tttggaatga atactgacaa tattccatga gggtgtgcaa gcacaaattt taccaatctg   5520

acctctttga agttgcagaa tgctttgaaa ttctaatggt atctgaaata tcagctcata   5580

gaaagtaaca aaatttgctg tcaccttaaa taagacattt taattttgtt ataatgtaca   5640

atttagaagt ttgattaatt atattatcta tttaggcatt aatataaaag aggtaggagt   5700

ctgttattta aaaaaagcat taaatttaaa aaaaaactgt cttgtctact tttagcttca   5760

ttctcccata ttttgaaggg tgtgtaactt cagctctgca ggattgcatg gggtaaaact   5820

tgttaccaac acatgtgaac cattgctaca ttgtaggttg tgatcatttt gccccactga   5880

agcccatgta tctgacctta cgtgcctttt gaactaggag aatcgggcta atttattaat   5940

gatgataatt ataatgtatc tgtacagcac tttttacatt tgcgaagtgc tttccaatcc   6000

atgttagtta ctagttatta cagctgtaag gataaaacac gtcatgtgga ttcattttga   6060

attggtgcta ttggtatttc ctctgttatt gctaataaat gaaaatggtg gtatg        6115


<210>  254
<211>  949
<212>  PRT
<213>  Homo sapiens

<400>  254


Met Phe Gly Phe Gln Arg Arg Gly Leu Gly Thr Pro Arg Leu Gln Leu 
1               5                   10                  15      


Trp Leu Leu Leu Leu Glu Phe Trp Glu Val Gly Ser Gly Gln Leu His 
            20                  25                  30          


Tyr Ser Val Ser Glu Glu Ala Lys His Gly Thr Phe Val Gly Arg Ile 
        35                  40                  45              


Ala Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Gln Arg Leu Phe 
    50                  55                  60                  


Arg Val Ala Ser Lys Thr His Gly Asp Leu Leu Glu Val Asn Leu Gln 
65                  70                  75                  80  


Asn Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Gly Gln Ser Ala Glu Cys Ser Ile His Leu Glu Val Ile Val Asp Arg 
            100                 105                 110         


Pro Leu Gln Val Phe His Val Asn Val Glu Val Lys Asp Ile Asn Asp 
        115                 120                 125             


Asn Pro Pro Val Phe Ser Leu Arg Glu Gln Lys Leu Leu Ile Ala Glu 
    130                 135                 140                 


Ser Lys Gln Ser Asp Ser Arg Phe Pro Leu Glu Gly Ala Ser Asp Ala 
145                 150                 155                 160 


Asp Ile Glu Glu Asn Ala Leu Leu Thr Tyr Arg Leu Ser Lys Asn Glu 
                165                 170                 175     


Tyr Phe Ser Leu Asp Ser Pro Thr Asn Gly Lys Gln Ile Lys Arg Leu 
            180                 185                 190         


Ser Leu Ile Leu Lys Lys Ser Leu Asp Arg Glu Lys Thr Pro Glu Leu 
        195                 200                 205             


Asn Leu Leu Leu Thr Ala Thr Asp Gly Gly Lys Pro Glu Leu Thr Gly 
    210                 215                 220                 


Thr Val Arg Leu Leu Val Gln Val Leu Asp Val Asn Asp Asn Asp Pro 
225                 230                 235                 240 


Glu Phe Asp Lys Ser Glu Tyr Lys Val Ser Leu Met Glu Asn Ala Ala 
                245                 250                 255     


Lys Glu Thr Leu Val Leu Lys Leu Asn Ala Thr Asp Arg Asp Glu Gly 
            260                 265                 270         


Val Asn Gly Glu Val Thr Tyr Ser Leu Met Ser Ile Lys Pro Asn Gly 
        275                 280                 285             


Arg His Leu Phe Thr Leu Asp Gln Asn Asn Gly Glu Val Arg Val Asn 
    290                 295                 300                 


Gly Thr Leu Asp Tyr Glu Glu Asn Lys Phe Tyr Lys Ile Glu Val Gln 
305                 310                 315                 320 


Ala Thr Asp Lys Gly Thr Pro Pro Met Ala Gly His Cys Thr Val Trp 
                325                 330                 335     


Val Glu Ile Leu Asp Thr Asn Asp Asn Ser Pro Glu Val Ala Val Thr 
            340                 345                 350         


Ser Leu Ser Leu Pro Val Arg Glu Asp Ala Gln Pro Ser Thr Val Ile 
        355                 360                 365             


Ala Leu Ile Ser Val Ser Asp Arg Asp Ser Gly Val Asn Gly Gln Val 
    370                 375                 380                 


Thr Cys Ser Leu Thr Pro His Val Pro Phe Lys Leu Val Ser Thr Phe 
385                 390                 395                 400 


Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu Asn 
                405                 410                 415     


Val Trp Ala Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser Pro 
            420                 425                 430         


Ser Leu Trp Ala Thr Ala Arg Val Ser Val Glu Val Ala Asp Val Asn 
        435                 440                 445             


Asp Asn Ala Pro Ala Phe Ala Gln Pro Glu Tyr Thr Val Phe Val Lys 
    450                 455                 460                 


Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Arg Asp 
465                 470                 475                 480 


Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu Arg 
                485                 490                 495     


Arg Leu Gly Asp Arg Ala Leu Ser Ser Tyr Val Ser Val His Ala Glu 
            500                 505                 510         


Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu Glu 
        515                 520                 525             


Leu Leu Gln Phe Gln Val Ser Ala Arg Asp Ala Gly Val Pro Pro Leu 
    530                 535                 540                 


Ser Ser Asn Val Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp Asn 
545                 550                 555                 560 


Ala Pro Ala Leu Leu Ala Thr Gln Ala Gly Ser Ala Gly Gly Ala Val 
                565                 570                 575     


Asn Lys Leu Val Pro Arg Ser Val Gly Ala Gly His Val Val Ala Lys 
            580                 585                 590         


Val Arg Ala Val Asp Ala Asp Ser Gly Tyr Asn Ala Trp Leu Ser Tyr 
        595                 600                 605             


Glu Leu Gln Pro Ala Ala Gly Gly Ser Arg Ile Pro Phe Arg Val Gly 
    610                 615                 620                 


Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Ala Leu Asp Glu Ala Asp 
625                 630                 635                 640 


Ser Pro Arg His Arg Leu Leu Val Leu Val Lys Asp His Gly Glu Pro 
                645                 650                 655     


Ala Leu Thr Ala Thr Ala Thr Val Leu Val Ser Leu Val Glu Ser Gly 
            660                 665                 670         


Gln Ala Pro Lys Ala Ser Ser Arg Thr Leu Ala Gly Ala Ala Ser Pro 
        675                 680                 685             


Glu Ala Ala Leu Val Asp Val Asn Val Tyr Leu Ile Ile Ala Ile Cys 
    690                 695                 700                 


Val Val Ser Ser Leu Leu Val Leu Thr Leu Leu Leu Tyr Thr Ala Leu 
705                 710                 715                 720 


Trp Trp Ser Ala Thr Pro Thr Glu Gly Ala Cys Ala Pro Gly Lys Pro 
                725                 730                 735     


Thr Leu Val Cys Ser Arg Ala Val Gly Ser Trp Ser Tyr Ser Gln Gln 
            740                 745                 750         


Arg Arg Gln Arg Val Cys Ser Glu Glu Gly Pro Pro Lys Thr Asp Leu 
        755                 760                 765             


Met Ala Phe Ser Pro Ser Leu Pro Leu Gly Leu Asn Lys Glu Glu Glu 
    770                 775                 780                 


Gly Glu Arg Gln Glu Pro Gly Ser Asn His Pro Gly Gln Pro Arg Gln 
785                 790                 795                 800 


Pro Asn Pro Asp Trp Arg Tyr Ser Ala Ser Leu Arg Ala Gly Met His 
                805                 810                 815     


Ser Ser Val His Leu Glu Glu Ala Gly Ile Leu Arg Ala Gly Pro Gly 
            820                 825                 830         


Gly Pro Asp Gln Gln Trp Pro Thr Val Ser Ser Ala Thr Pro Glu Pro 
        835                 840                 845             


Glu Ala Gly Glu Val Ser Pro Pro Val Gly Ala Gly Val Asn Ser Asn 
    850                 855                 860                 


Ser Trp Thr Phe Lys Tyr Gly Pro Gly Asn Pro Lys Gln Ser Gly Pro 
865                 870                 875                 880 


Gly Glu Leu Pro Asp Lys Phe Ile Ile Pro Gly Ser Pro Ala Ile Ile 
                885                 890                 895     


Ser Ile Arg Gln Glu Pro Thr Asn Ser Gln Ile Asp Lys Ser Asp Phe 
            900                 905                 910         


Ile Thr Phe Gly Lys Lys Glu Glu Thr Lys Lys Lys Lys Lys Lys Lys 
        915                 920                 925             


Lys Gly Asn Lys Thr Gln Glu Lys Lys Glu Lys Gly Asn Ser Thr Thr 
    930                 935                 940                 


Asp Asn Ser Asp Gln 
945                 

<210>  255
<211>  3291
<212>  DNA
<213>  Homo sapiens

<400>  255
ttttcctttg tggattcttt tttaaaacta ccaagtttga gaatatgaat atatttgttt     60

ttcatattgt tctgcaatga atataaagtc acttataatc agaaagcaat taaatgtaaa    120

taacagtaaa gaatgagaac tatagaaaat agatatgaaa atgcaagccc acagagatga    180

gaatagatca tgtggaacat aaacactaaa gagctgcttt tataaaactt caattttttc    240

tttgagttcc ctagcagcca aagtaacaag ggagactgaa agtaaaacaa ttcaaatttg    300

atagtatttt tatatgagga acaacacttt caggaaatgt ttaaccctag tttttcatga    360

ggccacctta acaactgaat tctctttctc tctcactctg tgtataagta ttttagataa    420

gtaaaagaac aatgttataa tgttaagtca aacatagaca caataattta aatttgatgt    480

taatcgagaa atacaatgcc atttccatat atatttagtt tcaatatgac ttataatctg    540

aatattccat aaataagcac gttggaaata tttgggggaa gaaacccaaa acacgtgaaa    600

ttctgtggtg gtaaatgcag tgcacagtac tcacagtttt aggcgcaagg tgtcgctctt    660

tacttggtgg aaagttcatt taaaggttgg tctgaacagt gaggcactcc catacaaagg    720

aactccatca taccggatgc caccgtttaa ggatcctttg aaacttctta agaattcaac    780

gagattttta acctgaaact gaagaatctg gtactgtaag tgtaaagaag cttattttgg    840

aagccaattt cgtatgcgat gtttggtttt cagagaaggg gattgggcac cccacgacta    900

cagctctggc ttctcctcct cgaattctgg gaggtgggga gcggccagct ccactactcc    960

gtctcggagg aggccaaaca cggcaccttc gtgggccgca tcgcgcagga cctggggctg   1020

gagctggcgg agctggtgca gcgcctgttc cgggtggcgt ccaaaacaca tggggacctt   1080

ctggaggtaa atctgcagaa tggcattttg tttgtgaatt ctcggatcga ccgcgaggag   1140

ctgtgcgggc agagcgcgga gtgcagcatc cacctggagg tgatcgtgga caggccgctg   1200

caggttttcc atgtgaacgt ggaggtgaag gacattaacg acaacccgcc ggtgttctcg   1260

ctcagagaac aaaagctgct gattgcggaa tctaagcaat cggactcgcg ttttccacta   1320

gagggagctt ctgatgctga cattgaagag aatgctctat tgacctacag gctaagtaaa   1380

aatgagtatt tttctttaga ttcaccaaca aatggtaagc agattaaaag actgtcactt   1440

attttaaaga agtctctgga tagagagaaa actccggaac ttaatttgct gctaacagct   1500

acagacgggg gaaaaccaga gcttactggc accgttcggc tgttagtcca agtcttggat   1560

gtcaacgaca atgatccaga gtttgataaa tcagaatata aggtgagcct tatggaaaat   1620

gctgctaaag aaactcttgt gctcaaacta aacgccacag accgagacga aggagtcaat   1680

ggagaggtaa catactcctt aatgtcaatt aagcccaatg gaagacactt atttacacta   1740

gatcaaaata atggagaagt gagggtcaat ggaactttag attatgaaga aaacaagttt   1800

tataaaattg aagtacaggc tacagataag gggactcccc caatggcagg tcactgtaca   1860

gtctgggtgg aaatcttgga caccaacgat aactctcctg aagtcgccgt gacttccttg   1920

tccctcccag tacgagagga cgctcagccc agcacggtca ttgccctgat cagcgtgtct   1980

gaccgtgact caggtgtcaa cggacaggtg acctgctcgc tgacgcccca cgttcccttc   2040

aagctggtgt ccaccttcaa gaattactac tcgttggtgc tggacagcgc cctggaccgc   2100

gagaacgtgt gggcctatga actggtggtg actgcgcggg atgggggttc gccttctctg   2160

tgggccacgg ccagggtatc cgtggaggtg gccgacgtga acgacaatgc gcctgcgttc   2220

gcacagcccg agtacaccgt gttcgtgaag gagaacaacc caccaggctg ccacatcttc   2280

acagtgtcgg cgcgggacgc ggacgcgcag gagaacgcgc tggtgtccta ctcgctggtg   2340

gagcggcggt tgggcgaccg cgcgctgtcg agctacgtgt cggtgcacgc ggagagcggc   2400

aaggtgtacg cgctgcagcc gttggaccac gaggagctgg agctgctaca gttccaggtg   2460

agcgcgcgcg atgcgggcgt gccgcctctg agcagcaacg tgacgctgca ggtgttcgtg   2520

ctggacgaga acgacaacgc gccggcactg ctggcgactc aggctggcag cgcgggaggc   2580

gcagttaaca agctagtacc gcggtcggtg ggtgcgggcc acgtggtggc gaaggtgcgc   2640

gcagtggatg cggactcagg ctacaacgcg tggctttcat atgaattgca gccggcggcg   2700

ggcggctcgc gcatcccgtt ccgcgtgggg ctgtacacgg gcgagataag cacaacgcgt   2760

gccctggacg aggcagactc gccgcgccac cgacttctag tactggtgaa ggatcacggt   2820

gagccggcgc tgacggccac ggccaccgtg ctggtgtcgt tggtggagag cggacaggcg   2880

ccaaaggcct cttcccggac tttggcgggc gccgcgagcc cagaggctgc gctggtggat   2940

gtcaacgtgt acctgatcat cgccatctgc gtggtgtcca gcctcctggt actcacgctg   3000

ctgctgtata cggcgctgtg gtggtcggca acgcccactg agggcgcgtg cgcgccgggg   3060

aagcccacgc tggtgtgctc ccgcgcggtg gggagctggt catactcgca gcagaggcgg   3120

cagagggtgt gctctgagga gggcccacct aagacggacc tcatggcctt cagccccagt   3180

cttcctctag gtctgaataa agaggaggaa ggggaaagac aggagccagg gtcaaatcac   3240

cccggacagg tgagttttct acagattcca cctatcagga agtgtatgtg a            3291


<210>  256
<211>  810
<212>  PRT
<213>  Homo sapiens

<400>  256


Met Phe Gly Phe Gln Arg Arg Gly Leu Gly Thr Pro Arg Leu Gln Leu 
1               5                   10                  15      


Trp Leu Leu Leu Leu Glu Phe Trp Glu Val Gly Ser Gly Gln Leu His 
            20                  25                  30          


Tyr Ser Val Ser Glu Glu Ala Lys His Gly Thr Phe Val Gly Arg Ile 
        35                  40                  45              


Ala Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Gln Arg Leu Phe 
    50                  55                  60                  


Arg Val Ala Ser Lys Thr His Gly Asp Leu Leu Glu Val Asn Leu Gln 
65                  70                  75                  80  


Asn Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Gly Gln Ser Ala Glu Cys Ser Ile His Leu Glu Val Ile Val Asp Arg 
            100                 105                 110         


Pro Leu Gln Val Phe His Val Asn Val Glu Val Lys Asp Ile Asn Asp 
        115                 120                 125             


Asn Pro Pro Val Phe Ser Leu Arg Glu Gln Lys Leu Leu Ile Ala Glu 
    130                 135                 140                 


Ser Lys Gln Ser Asp Ser Arg Phe Pro Leu Glu Gly Ala Ser Asp Ala 
145                 150                 155                 160 


Asp Ile Glu Glu Asn Ala Leu Leu Thr Tyr Arg Leu Ser Lys Asn Glu 
                165                 170                 175     


Tyr Phe Ser Leu Asp Ser Pro Thr Asn Gly Lys Gln Ile Lys Arg Leu 
            180                 185                 190         


Ser Leu Ile Leu Lys Lys Ser Leu Asp Arg Glu Lys Thr Pro Glu Leu 
        195                 200                 205             


Asn Leu Leu Leu Thr Ala Thr Asp Gly Gly Lys Pro Glu Leu Thr Gly 
    210                 215                 220                 


Thr Val Arg Leu Leu Val Gln Val Leu Asp Val Asn Asp Asn Asp Pro 
225                 230                 235                 240 


Glu Phe Asp Lys Ser Glu Tyr Lys Val Ser Leu Met Glu Asn Ala Ala 
                245                 250                 255     


Lys Glu Thr Leu Val Leu Lys Leu Asn Ala Thr Asp Arg Asp Glu Gly 
            260                 265                 270         


Val Asn Gly Glu Val Thr Tyr Ser Leu Met Ser Ile Lys Pro Asn Gly 
        275                 280                 285             


Arg His Leu Phe Thr Leu Asp Gln Asn Asn Gly Glu Val Arg Val Asn 
    290                 295                 300                 


Gly Thr Leu Asp Tyr Glu Glu Asn Lys Phe Tyr Lys Ile Glu Val Gln 
305                 310                 315                 320 


Ala Thr Asp Lys Gly Thr Pro Pro Met Ala Gly His Cys Thr Val Trp 
                325                 330                 335     


Val Glu Ile Leu Asp Thr Asn Asp Asn Ser Pro Glu Val Ala Val Thr 
            340                 345                 350         


Ser Leu Ser Leu Pro Val Arg Glu Asp Ala Gln Pro Ser Thr Val Ile 
        355                 360                 365             


Ala Leu Ile Ser Val Ser Asp Arg Asp Ser Gly Val Asn Gly Gln Val 
    370                 375                 380                 


Thr Cys Ser Leu Thr Pro His Val Pro Phe Lys Leu Val Ser Thr Phe 
385                 390                 395                 400 


Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu Asn 
                405                 410                 415     


Val Trp Ala Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser Pro 
            420                 425                 430         


Ser Leu Trp Ala Thr Ala Arg Val Ser Val Glu Val Ala Asp Val Asn 
        435                 440                 445             


Asp Asn Ala Pro Ala Phe Ala Gln Pro Glu Tyr Thr Val Phe Val Lys 
    450                 455                 460                 


Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Arg Asp 
465                 470                 475                 480 


Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu Arg 
                485                 490                 495     


Arg Leu Gly Asp Arg Ala Leu Ser Ser Tyr Val Ser Val His Ala Glu 
            500                 505                 510         


Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu Glu 
        515                 520                 525             


Leu Leu Gln Phe Gln Val Ser Ala Arg Asp Ala Gly Val Pro Pro Leu 
    530                 535                 540                 


Ser Ser Asn Val Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp Asn 
545                 550                 555                 560 


Ala Pro Ala Leu Leu Ala Thr Gln Ala Gly Ser Ala Gly Gly Ala Val 
                565                 570                 575     


Asn Lys Leu Val Pro Arg Ser Val Gly Ala Gly His Val Val Ala Lys 
            580                 585                 590         


Val Arg Ala Val Asp Ala Asp Ser Gly Tyr Asn Ala Trp Leu Ser Tyr 
        595                 600                 605             


Glu Leu Gln Pro Ala Ala Gly Gly Ser Arg Ile Pro Phe Arg Val Gly 
    610                 615                 620                 


Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Ala Leu Asp Glu Ala Asp 
625                 630                 635                 640 


Ser Pro Arg His Arg Leu Leu Val Leu Val Lys Asp His Gly Glu Pro 
                645                 650                 655     


Ala Leu Thr Ala Thr Ala Thr Val Leu Val Ser Leu Val Glu Ser Gly 
            660                 665                 670         


Gln Ala Pro Lys Ala Ser Ser Arg Thr Leu Ala Gly Ala Ala Ser Pro 
        675                 680                 685             


Glu Ala Ala Leu Val Asp Val Asn Val Tyr Leu Ile Ile Ala Ile Cys 
    690                 695                 700                 


Val Val Ser Ser Leu Leu Val Leu Thr Leu Leu Leu Tyr Thr Ala Leu 
705                 710                 715                 720 


Trp Trp Ser Ala Thr Pro Thr Glu Gly Ala Cys Ala Pro Gly Lys Pro 
                725                 730                 735     


Thr Leu Val Cys Ser Arg Ala Val Gly Ser Trp Ser Tyr Ser Gln Gln 
            740                 745                 750         


Arg Arg Gln Arg Val Cys Ser Glu Glu Gly Pro Pro Lys Thr Asp Leu 
        755                 760                 765             


Met Ala Phe Ser Pro Ser Leu Pro Leu Gly Leu Asn Lys Glu Glu Glu 
    770                 775                 780                 


Gly Glu Arg Gln Glu Pro Gly Ser Asn His Pro Gly Gln Val Ser Phe 
785                 790                 795                 800 


Leu Gln Ile Pro Pro Ile Arg Lys Cys Met 
                805                 810 

<210>  257
<211>  5360
<212>  DNA
<213>  Homo sapiens

<400>  257
tgactgtgat gctggaaaaa atttactaaa tatgtactta cagaaaaggg tgactgctca     60

taaaatacct caggcaagcg atcccttaaa actgattgtc ccaactcaga ggccctcatt    120

ttctgcaatg gtgattatcg gaccaagagg cccgggatcc cagcgtctgc tgctctcgct    180

tctgctcctt gcagcctggg aggtggggag cggccagctc cactactccg tctacgagga    240

ggccaaacac ggcaccttcg tgggccgcat cgctcaggac ctggggctgg agctggcgga    300

gctggtgccg cgcctgttcc gggtggcgtc caaaagacac ggggaccttc tggaggtaaa    360

tctgcagaat ggcattttgt ttgtgaattc tcggatcgac cgcgagaagc tgtgcgggcg    420

gagcgcggag tgcagtatcc acctggaggt gatcgtggac aggccgctgc aggttttcca    480

tgtggacgtg gaggtgaagg acattaacga caacccgccg gtgttcagag aaagggaaca    540

aaaggtacct gtttctgaat ctgcgcctct ggactctcat tttcctctag agggcgcttc    600

tgatgcggat atcggcgtaa actctctttt gacctatgcg ttaagtctaa atgagaattt    660

tgagcttaaa ataaaaacaa aaaaagataa aagtatattg cctgaattag ttcttcggaa    720

gttattggac agagagcaaa cgccaaaact caatttattg ctgatggtaa tcgatggcgg    780

taaaccagaa ctaacagggt ctgtccagat tcaaataacc gtcctggatg tgaatgacaa    840

tggtccggcg tttgataagc ccagctataa agtagtgttg tctgaaaatg tccaaaacga    900

cacaagagtg atccaactaa atgcttccga tccagacgaa ggacttaatg gagaaatttc    960

ctatgggatc aaaatgattt tgccagtgag tgagaaatgt atgttttcaa taaatccaga   1020

cacaggtgaa attagaattt atggtgaact ggattttgaa gagaataatg cctatgaaat   1080

tcaggttaac gccattgata aagggattcc ttccatggca ggtcacagca tggtcctggt   1140

ggaagttctg gacgtgaatg acaatgtccc tgaagtaatg gttacttcac tgtcgctccc   1200

tgtgcaagag gatgctcagg tgggtaccgt cattgccctg attagcgtgt cggatcgtga   1260

ctctggagcc aatggacagg tcatctgctc actgacacct catgttccct tcaagctggt   1320

gtccacctac aagaattact actcgttggt gctggacagc gccctggacc gcgagagcgt   1380

gtcggcctat gagctggtgg tgactgcgcg ggatgggggc tcgccttcgc tgtgggccac   1440

ggctagagtg tccgtggagg tggccgacgt gaacgacaat gcgcctgcgt tcgcgcagcc   1500

cgagtacaca gtgttcgtga aggagaacaa cccgccgggc tgccacatct tcacggtgtc   1560

ggcatgggac gcggacgcgc agaagaacgc gctggtgtcc tactcgctgg tggagcggcg   1620

ggtgggcgag cacgcactgt cgagctacgt gtcggtgcac gcggagagcg gcaaggtgta   1680

cgcgctgcag ccgctagacc acgaggagct ggagctgctg cagttccagg tgagcgcgcg   1740

cgacgccggc gtgccgcctc tgggcagcaa cgtgacgctg caggtgttcg tgctggacga   1800

gaacgacaac gcgccggcac tgctggcgac tccggctggc agcgcaggag gcgcagttag   1860

cgagttggta ccgcggtcgg tgggtgcggg ccacgtggtg gcgaaagtgc gcgcggtgga   1920

cgctgactcc ggctataacg cttggctgtc ctacgagttg caaccggcgg cggtcggcgc   1980

gcacatcccg ttccacgtgg ggctgtacac tggcgagatc agcacgacac gcatcctgga   2040

tgaggcggac gctccgcgcc accgcctgct ggtgctggtg aaggaccacg gtgagcccgc   2100

gctgacgtcc acggccacgg tgctggtgtc gctggtggag aacggccagg ccccaaagac   2160

gtcgtcgcgg gcctcagtgg gcgctgtgga tcccgaagcg gctctggtgg atattaacgt   2220

gtacctcatc atcgccatct gtgcggtgtc cagcctgctg gtgctcacgc tgctgctgta   2280

cactgcgctg cgttgctcag cgccgcccac cgtgagccgg tgcgcgccgg gcaagcccac   2340

gctggtgtgc tccagcgccg tggggagttg gtcttactcg cagcagagga ggcagagggt   2400

gtgctctgca gagagcccgc ccaagacgga cctcatggcc ttcagcccaa gccttcagct   2460

gtctcgagaa gattgtttaa atcctcccag tgaaccacga cagcccaacc ctgactggcg   2520

ttactctgcc tccctgagag caggcatgca cagctctgtg cacctagagg aggctggcat   2580

tctacgggct ggtccaggag ggcctgatca gcagtggcca acagtatcca gtgcaacacc   2640

agaaccagag gcaggagaag tgtcccctcc agtcggtgcg ggtgtcaaca gcaacagctg   2700

gacctttaaa tacggaccag gcaaccccaa acaatccggt cccggtgagt tgcccgacaa   2760

attcattatc ccaggatctc ctgcaatcat ctccatccgg caggagccta ctaacagcca   2820

aattgacaaa agtgacttca taaccttcgg caaaaaggag gagaccaaga aaaagaagaa   2880

aaagaagaag ggtaacaaga cccaggagaa aaaagagaaa gggaacagca cgactgacaa   2940

cagtgaccag tgaggtcctc aaatggaaac aagccactta gccagttttt gtaataatgg   3000

caaatctctc ccatgtagca attccctgct cctttttcct atctacatga gccctcttag   3060

agacctcaga aatctgcaga aagttccctg tgtctgtcta gaacgcattt aacaggtttt   3120

gtcgtaaaag ctttactaag tctggtgtta actctttctc tccactctgg cttgttttca   3180

gaacctaaaa agcagaccca agtttccttt ctcctccgcc gcaaaggaga ggcttcccag   3240

ccccgccagt gagaggttgg actctctgcc ctgtgctccg gggatcctgt cttgatgaca   3300

cttgcagggc aggctgaaaa gttttgagat tgagcagctt gggagtttgt ggccactggg   3360

tatgtgtggc taccgcgggt atgcgagtgc cagatattgg ctgagacgag ccagcttaga   3420

ctaattggta caaggaaggc aagaaaacaa agacaaataa acagcggaag ttatcagtat   3480

ggaggggaag tgtaaactta aagggaccag actttctaaa tcttacaact caagaggtgg   3540

cagccaccct ctaggagaca aaactacccc cactgacaag gctttaggag accctaaagt   3600

ctgttggctg tgacgtcatt atacctaaaa tctgcatcat acctgcaagc caacagttca   3660

gtgttttaac agagaaccac cctgggaaac agaagcagat ctgatgtgtt tcctatacat   3720

gtcctgtgct cactttatta aaaattcttt tgcacacaat gtttatgaaa aggccagatc   3780

cttttccaat acttatgcaa aagcaaaaga aaaccccgac acctcacctt tcgctgtttg   3840

ttgtttcata gatttattta aaaaaagaga aagtctatag ctataaatct ttaaagagaa   3900

atatgaatac aattccccta aactctcctc aaaagagaat tcagtctaca gccatttaaa   3960

tgatcattgc tgctacagaa gtgctttaag agaattgcct gaaacatctg tattatatcg   4020

gccacctgcc aatcacagct ttactctttc aggtcactct ggggctgcct cttgcatgta   4080

ttactaaata aaatgatctc tctttctctc tctctctctc ttttctaaga aacaattatg   4140

tgcactttga tacacaacct tctctaacca actatatatc aagacccaaa aattgaagaa   4200

aaatattgtt ttctcataca gtgagcagat ttttcaatct actaattctg tgacttgtct   4260

tggtgtgcta gcctacacct tctctttggt ttagttttcc ttttctataa cactctgaat   4320

tgctaatctt actaacacct atgatgttac ctgaaatcaa tctcccatat gtatgctgta   4380

tgctatgcta agactcctga aatatactta ctctgtgctt gtgtatgtga atgttaatgc   4440

aactattacc tagagtgaac tttaagcttt attgttgaat gtaattccat tatatttcct   4500

tttgtacacc tgtgaaaaag tggagtagtg tttttttaac cattgttaat cagcttttgt   4560

gtatgaaaga cacagtaaaa tttctttctt aaatcaagat actggtgatt caaggaattt   4620

tatttatggt ccagccaaga gccatctcgt gccaagactt ctgctggcaa gggaatggat   4680

aaagctgttt tgttctagta acaattttgg aatgaatact gacaatattc catgagggtg   4740

tgcaagcaca aattttacca atctgacctc tttgaagttg cagaatgctt tgaaattcta   4800

atggtatctg aaatatcagc tcatagaaag taacaaaatt tgctgtcacc ttaaataaga   4860

cattttaatt ttgttataat gtacaattta gaagtttgat taattatatt atctatttag   4920

gcattaatat aaaagaggta ggagtctgtt atttaaaaaa agcattaaat ttaaaaaaaa   4980

actgtcttgt ctacttttag cttcattctc ccatattttg aagggtgtgt aacttcagct   5040

ctgcaggatt gcatggggta aaacttgtta ccaacacatg tgaaccattg ctacattgta   5100

ggttgtgatc attttgcccc actgaagccc atgtatctga ccttacgtgc cttttgaact   5160

aggagaatcg ggctaattta ttaatgatga taattataat gtatctgtac agcacttttt   5220

acatttgcga agtgctttcc aatccatgtt agttactagt tattacagct gtaaggataa   5280

aacacgtcat gtggattcat tttgaattgg tgctattggt atttcctctg ttattgctaa   5340

taaatgaaaa tggtggtatg                                               5360


<210>  258
<211>  941
<212>  PRT
<213>  Homo sapiens

<400>  258


Met Val Ile Ile Gly Pro Arg Gly Pro Gly Ser Gln Arg Leu Leu Leu 
1               5                   10                  15      


Ser Leu Leu Leu Leu Ala Ala Trp Glu Val Gly Ser Gly Gln Leu His 
            20                  25                  30          


Tyr Ser Val Tyr Glu Glu Ala Lys His Gly Thr Phe Val Gly Arg Ile 
        35                  40                  45              


Ala Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Pro Arg Leu Phe 
    50                  55                  60                  


Arg Val Ala Ser Lys Arg His Gly Asp Leu Leu Glu Val Asn Leu Gln 
65                  70                  75                  80  


Asn Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Lys Leu Cys 
                85                  90                  95      


Gly Arg Ser Ala Glu Cys Ser Ile His Leu Glu Val Ile Val Asp Arg 
            100                 105                 110         


Pro Leu Gln Val Phe His Val Asp Val Glu Val Lys Asp Ile Asn Asp 
        115                 120                 125             


Asn Pro Pro Val Phe Arg Glu Arg Glu Gln Lys Val Pro Val Ser Glu 
    130                 135                 140                 


Ser Ala Pro Leu Asp Ser His Phe Pro Leu Glu Gly Ala Ser Asp Ala 
145                 150                 155                 160 


Asp Ile Gly Val Asn Ser Leu Leu Thr Tyr Ala Leu Ser Leu Asn Glu 
                165                 170                 175     


Asn Phe Glu Leu Lys Ile Lys Thr Lys Lys Asp Lys Ser Ile Leu Pro 
            180                 185                 190         


Glu Leu Val Leu Arg Lys Leu Leu Asp Arg Glu Gln Thr Pro Lys Leu 
        195                 200                 205             


Asn Leu Leu Leu Met Val Ile Asp Gly Gly Lys Pro Glu Leu Thr Gly 
    210                 215                 220                 


Ser Val Gln Ile Gln Ile Thr Val Leu Asp Val Asn Asp Asn Gly Pro 
225                 230                 235                 240 


Ala Phe Asp Lys Pro Ser Tyr Lys Val Val Leu Ser Glu Asn Val Gln 
                245                 250                 255     


Asn Asp Thr Arg Val Ile Gln Leu Asn Ala Ser Asp Pro Asp Glu Gly 
            260                 265                 270         


Leu Asn Gly Glu Ile Ser Tyr Gly Ile Lys Met Ile Leu Pro Val Ser 
        275                 280                 285             


Glu Lys Cys Met Phe Ser Ile Asn Pro Asp Thr Gly Glu Ile Arg Ile 
    290                 295                 300                 


Tyr Gly Glu Leu Asp Phe Glu Glu Asn Asn Ala Tyr Glu Ile Gln Val 
305                 310                 315                 320 


Asn Ala Ile Asp Lys Gly Ile Pro Ser Met Ala Gly His Ser Met Val 
                325                 330                 335     


Leu Val Glu Val Leu Asp Val Asn Asp Asn Val Pro Glu Val Met Val 
            340                 345                 350         


Thr Ser Leu Ser Leu Pro Val Gln Glu Asp Ala Gln Val Gly Thr Val 
        355                 360                 365             


Ile Ala Leu Ile Ser Val Ser Asp Arg Asp Ser Gly Ala Asn Gly Gln 
    370                 375                 380                 


Val Ile Cys Ser Leu Thr Pro His Val Pro Phe Lys Leu Val Ser Thr 
385                 390                 395                 400 


Tyr Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu 
                405                 410                 415     


Ser Val Ser Ala Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser 
            420                 425                 430         


Pro Ser Leu Trp Ala Thr Ala Arg Val Ser Val Glu Val Ala Asp Val 
        435                 440                 445             


Asn Asp Asn Ala Pro Ala Phe Ala Gln Pro Glu Tyr Thr Val Phe Val 
    450                 455                 460                 


Lys Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Trp 
465                 470                 475                 480 


Asp Ala Asp Ala Gln Lys Asn Ala Leu Val Ser Tyr Ser Leu Val Glu 
                485                 490                 495     


Arg Arg Val Gly Glu His Ala Leu Ser Ser Tyr Val Ser Val His Ala 
            500                 505                 510         


Glu Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu 
        515                 520                 525             


Glu Leu Leu Gln Phe Gln Val Ser Ala Arg Asp Ala Gly Val Pro Pro 
    530                 535                 540                 


Leu Gly Ser Asn Val Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp 
545                 550                 555                 560 


Asn Ala Pro Ala Leu Leu Ala Thr Pro Ala Gly Ser Ala Gly Gly Ala 
                565                 570                 575     


Val Ser Glu Leu Val Pro Arg Ser Val Gly Ala Gly His Val Val Ala 
            580                 585                 590         


Lys Val Arg Ala Val Asp Ala Asp Ser Gly Tyr Asn Ala Trp Leu Ser 
        595                 600                 605             


Tyr Glu Leu Gln Pro Ala Ala Val Gly Ala His Ile Pro Phe His Val 
    610                 615                 620                 


Gly Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Ile Leu Asp Glu Ala 
625                 630                 635                 640 


Asp Ala Pro Arg His Arg Leu Leu Val Leu Val Lys Asp His Gly Glu 
                645                 650                 655     


Pro Ala Leu Thr Ser Thr Ala Thr Val Leu Val Ser Leu Val Glu Asn 
            660                 665                 670         


Gly Gln Ala Pro Lys Thr Ser Ser Arg Ala Ser Val Gly Ala Val Asp 
        675                 680                 685             


Pro Glu Ala Ala Leu Val Asp Ile Asn Val Tyr Leu Ile Ile Ala Ile 
    690                 695                 700                 


Cys Ala Val Ser Ser Leu Leu Val Leu Thr Leu Leu Leu Tyr Thr Ala 
705                 710                 715                 720 


Leu Arg Cys Ser Ala Pro Pro Thr Val Ser Arg Cys Ala Pro Gly Lys 
                725                 730                 735     


Pro Thr Leu Val Cys Ser Ser Ala Val Gly Ser Trp Ser Tyr Ser Gln 
            740                 745                 750         


Gln Arg Arg Gln Arg Val Cys Ser Ala Glu Ser Pro Pro Lys Thr Asp 
        755                 760                 765             


Leu Met Ala Phe Ser Pro Ser Leu Gln Leu Ser Arg Glu Asp Cys Leu 
    770                 775                 780                 


Asn Pro Pro Ser Glu Pro Arg Gln Pro Asn Pro Asp Trp Arg Tyr Ser 
785                 790                 795                 800 


Ala Ser Leu Arg Ala Gly Met His Ser Ser Val His Leu Glu Glu Ala 
                805                 810                 815     


Gly Ile Leu Arg Ala Gly Pro Gly Gly Pro Asp Gln Gln Trp Pro Thr 
            820                 825                 830         


Val Ser Ser Ala Thr Pro Glu Pro Glu Ala Gly Glu Val Ser Pro Pro 
        835                 840                 845             


Val Gly Ala Gly Val Asn Ser Asn Ser Trp Thr Phe Lys Tyr Gly Pro 
    850                 855                 860                 


Gly Asn Pro Lys Gln Ser Gly Pro Gly Glu Leu Pro Asp Lys Phe Ile 
865                 870                 875                 880 


Ile Pro Gly Ser Pro Ala Ile Ile Ser Ile Arg Gln Glu Pro Thr Asn 
                885                 890                 895     


Ser Gln Ile Asp Lys Ser Asp Phe Ile Thr Phe Gly Lys Lys Glu Glu 
            900                 905                 910         


Thr Lys Lys Lys Lys Lys Lys Lys Lys Gly Asn Lys Thr Gln Glu Lys 
        915                 920                 925             


Lys Glu Lys Gly Asn Ser Thr Thr Asp Asn Ser Asp Gln 
    930                 935                 940     

<210>  259
<211>  2506
<212>  DNA
<213>  Homo sapiens

<400>  259
tgactgtgat gctggaaaaa atttactaaa tatgtactta cagaaaaggg tgactgctca     60

taaaatacct caggcaagcg atcccttaaa actgattgtc ccaactcaga ggccctcatt    120

ttctgcaatg gtgattatcg gaccaagagg cccgggatcc cagcgtctgc tgctctcgct    180

tctgctcctt gcagcctggg aggtggggag cggccagctc cactactccg tctacgagga    240

ggccaaacac ggcaccttcg tgggccgcat cgctcaggac ctggggctgg agctggcgga    300

gctggtgccg cgcctgttcc gggtggcgtc caaaagacac ggggaccttc tggaggtaaa    360

tctgcagaat ggcattttgt ttgtgaattc tcggatcgac cgcgagaagc tgtgcgggcg    420

gagcgcggag tgcagtatcc acctggaggt gatcgtggac aggccgctgc aggttttcca    480

tgtggacgtg gaggtgaagg acattaacga caacccgccg gtgttcagag aaagggaaca    540

aaaggtacct gtttctgaat ctgcgcctct ggactctcat tttcctctag agggcgcttc    600

tgatgcggat atcggcgtaa actctctttt gacctatgcg ttaagtctaa atgagaattt    660

tgagcttaaa ataaaaacaa aaaaagataa aagtatattg cctgaattag ttcttcggaa    720

gttattggac agagagcaaa cgccaaaact caatttattg ctgatggtaa tcgatggcgg    780

taaaccagaa ctaacagggt ctgtccagat tcaaataacc gtcctggatg tgaatgacaa    840

tggtccggcg tttgataagc ccagctataa agtagtgttg tctgaaaatg tccaaaacga    900

cacaagagtg atccaactaa atgcttccga tccagacgaa ggacttaatg gagaaatttc    960

ctatgggatc aaaatgattt tgccagtgag tgagaaatgt atgttttcaa taaatccaga   1020

cacaggtgaa attagaattt atggtgaact ggattttgaa gagaataatg cctatgaaat   1080

tcaggttaac gccattgata aagggattcc ttccatggca ggtcacagca tggtcctggt   1140

ggaagttctg gacgtgaatg acaatgtccc tgaagtaatg gttacttcac tgtcgctccc   1200

tgtgcaagag gatgctcagg tgggtaccgt cattgccctg attagcgtgt cggatcgtga   1260

ctctggagcc aatggacagg tcatctgctc actgacacct catgttccct tcaagctggt   1320

gtccacctac aagaattact actcgttggt gctggacagc gccctggacc gcgagagcgt   1380

gtcggcctat gagctggtgg tgactgcgcg ggatgggggc tcgccttcgc tgtgggccac   1440

ggctagagtg tccgtggagg tggccgacgt gaacgacaat gcgcctgcgt tcgcgcagcc   1500

cgagtacaca gtgttcgtga aggagaacaa cccgccgggc tgccacatct tcacggtgtc   1560

ggcatgggac gcggacgcgc agaagaacgc gctggtgtcc tactcgctgg tggagcggcg   1620

ggtgggcgag cacgcactgt cgagctacgt gtcggtgcac gcggagagcg gcaaggtgta   1680

cgcgctgcag ccgctagacc acgaggagct ggagctgctg cagttccagg tgagcgcgcg   1740

cgacgccggc gtgccgcctc tgggcagcaa cgtgacgctg caggtgttcg tgctggacga   1800

gaacgacaac gcgccggcac tgctggcgac tccggctggc agcgcaggag gcgcagttag   1860

cgagttggta ccgcggtcgg tgggtgcggg ccacgtggtg gcgaaagtgc gcgcggtgga   1920

cgctgactcc ggctataacg cttggctgtc ctacgagttg caaccggcgg cggtcggcgc   1980

gcacatcccg ttccacgtgg ggctgtacac tggcgagatc agcacgacac gcatcctgga   2040

tgaggcggac gctccgcgcc accgcctgct ggtgctggtg aaggaccacg gtgagcccgc   2100

gctgacgtcc acggccacgg tgctggtgtc gctggtggag aacggccagg ccccaaagac   2160

gtcgtcgcgg gcctcagtgg gcgctgtgga tcccgaagcg gctctggtgg atattaacgt   2220

gtacctcatc atcgccatct gtgcggtgtc cagcctgctg gtgctcacgc tgctgctgta   2280

cactgcgctg cgttgctcag cgccgcccac cgtgagccgg tgcgcgccgg gcaagcccac   2340

gctggtgtgc tccagcgccg tggggagttg gtcttactcg cagcagagga ggcagagggt   2400

gtgctctgca gagagcccgc ccaagacgga cctcatggcc ttcagcccaa gccttcagct   2460

gtctcgagaa gattgtttaa atcctcccag tgaagtaagt tattaa                  2506


<210>  260
<211>  792
<212>  PRT
<213>  Homo sapiens

<400>  260


Met Val Ile Ile Gly Pro Arg Gly Pro Gly Ser Gln Arg Leu Leu Leu 
1               5                   10                  15      


Ser Leu Leu Leu Leu Ala Ala Trp Glu Val Gly Ser Gly Gln Leu His 
            20                  25                  30          


Tyr Ser Val Tyr Glu Glu Ala Lys His Gly Thr Phe Val Gly Arg Ile 
        35                  40                  45              


Ala Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Pro Arg Leu Phe 
    50                  55                  60                  


Arg Val Ala Ser Lys Arg His Gly Asp Leu Leu Glu Val Asn Leu Gln 
65                  70                  75                  80  


Asn Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Lys Leu Cys 
                85                  90                  95      


Gly Arg Ser Ala Glu Cys Ser Ile His Leu Glu Val Ile Val Asp Arg 
            100                 105                 110         


Pro Leu Gln Val Phe His Val Asp Val Glu Val Lys Asp Ile Asn Asp 
        115                 120                 125             


Asn Pro Pro Val Phe Arg Glu Arg Glu Gln Lys Val Pro Val Ser Glu 
    130                 135                 140                 


Ser Ala Pro Leu Asp Ser His Phe Pro Leu Glu Gly Ala Ser Asp Ala 
145                 150                 155                 160 


Asp Ile Gly Val Asn Ser Leu Leu Thr Tyr Ala Leu Ser Leu Asn Glu 
                165                 170                 175     


Asn Phe Glu Leu Lys Ile Lys Thr Lys Lys Asp Lys Ser Ile Leu Pro 
            180                 185                 190         


Glu Leu Val Leu Arg Lys Leu Leu Asp Arg Glu Gln Thr Pro Lys Leu 
        195                 200                 205             


Asn Leu Leu Leu Met Val Ile Asp Gly Gly Lys Pro Glu Leu Thr Gly 
    210                 215                 220                 


Ser Val Gln Ile Gln Ile Thr Val Leu Asp Val Asn Asp Asn Gly Pro 
225                 230                 235                 240 


Ala Phe Asp Lys Pro Ser Tyr Lys Val Val Leu Ser Glu Asn Val Gln 
                245                 250                 255     


Asn Asp Thr Arg Val Ile Gln Leu Asn Ala Ser Asp Pro Asp Glu Gly 
            260                 265                 270         


Leu Asn Gly Glu Ile Ser Tyr Gly Ile Lys Met Ile Leu Pro Val Ser 
        275                 280                 285             


Glu Lys Cys Met Phe Ser Ile Asn Pro Asp Thr Gly Glu Ile Arg Ile 
    290                 295                 300                 


Tyr Gly Glu Leu Asp Phe Glu Glu Asn Asn Ala Tyr Glu Ile Gln Val 
305                 310                 315                 320 


Asn Ala Ile Asp Lys Gly Ile Pro Ser Met Ala Gly His Ser Met Val 
                325                 330                 335     


Leu Val Glu Val Leu Asp Val Asn Asp Asn Val Pro Glu Val Met Val 
            340                 345                 350         


Thr Ser Leu Ser Leu Pro Val Gln Glu Asp Ala Gln Val Gly Thr Val 
        355                 360                 365             


Ile Ala Leu Ile Ser Val Ser Asp Arg Asp Ser Gly Ala Asn Gly Gln 
    370                 375                 380                 


Val Ile Cys Ser Leu Thr Pro His Val Pro Phe Lys Leu Val Ser Thr 
385                 390                 395                 400 


Tyr Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu 
                405                 410                 415     


Ser Val Ser Ala Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser 
            420                 425                 430         


Pro Ser Leu Trp Ala Thr Ala Arg Val Ser Val Glu Val Ala Asp Val 
        435                 440                 445             


Asn Asp Asn Ala Pro Ala Phe Ala Gln Pro Glu Tyr Thr Val Phe Val 
    450                 455                 460                 


Lys Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Trp 
465                 470                 475                 480 


Asp Ala Asp Ala Gln Lys Asn Ala Leu Val Ser Tyr Ser Leu Val Glu 
                485                 490                 495     


Arg Arg Val Gly Glu His Ala Leu Ser Ser Tyr Val Ser Val His Ala 
            500                 505                 510         


Glu Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu 
        515                 520                 525             


Glu Leu Leu Gln Phe Gln Val Ser Ala Arg Asp Ala Gly Val Pro Pro 
    530                 535                 540                 


Leu Gly Ser Asn Val Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp 
545                 550                 555                 560 


Asn Ala Pro Ala Leu Leu Ala Thr Pro Ala Gly Ser Ala Gly Gly Ala 
                565                 570                 575     


Val Ser Glu Leu Val Pro Arg Ser Val Gly Ala Gly His Val Val Ala 
            580                 585                 590         


Lys Val Arg Ala Val Asp Ala Asp Ser Gly Tyr Asn Ala Trp Leu Ser 
        595                 600                 605             


Tyr Glu Leu Gln Pro Ala Ala Val Gly Ala His Ile Pro Phe His Val 
    610                 615                 620                 


Gly Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Ile Leu Asp Glu Ala 
625                 630                 635                 640 


Asp Ala Pro Arg His Arg Leu Leu Val Leu Val Lys Asp His Gly Glu 
                645                 650                 655     


Pro Ala Leu Thr Ser Thr Ala Thr Val Leu Val Ser Leu Val Glu Asn 
            660                 665                 670         


Gly Gln Ala Pro Lys Thr Ser Ser Arg Ala Ser Val Gly Ala Val Asp 
        675                 680                 685             


Pro Glu Ala Ala Leu Val Asp Ile Asn Val Tyr Leu Ile Ile Ala Ile 
    690                 695                 700                 


Cys Ala Val Ser Ser Leu Leu Val Leu Thr Leu Leu Leu Tyr Thr Ala 
705                 710                 715                 720 


Leu Arg Cys Ser Ala Pro Pro Thr Val Ser Arg Cys Ala Pro Gly Lys 
                725                 730                 735     


Pro Thr Leu Val Cys Ser Ser Ala Val Gly Ser Trp Ser Tyr Ser Gln 
            740                 745                 750         


Gln Arg Arg Gln Arg Val Cys Ser Ala Glu Ser Pro Pro Lys Thr Asp 
        755                 760                 765             


Leu Met Ala Phe Ser Pro Ser Leu Gln Leu Ser Arg Glu Asp Cys Leu 
    770                 775                 780                 


Asn Pro Pro Ser Glu Val Ser Tyr 
785                 790         

<210>  261
<211>  5260
<212>  DNA
<213>  Homo sapiens

<400>  261
atgctgtctt cctggcaagg aggcccaaga ccgcggcaac tactgctctg gcttctgatc     60

ctcgcagcct gggagacggg tagtggccag ctccactact ccgtccccga ggaagcaaaa    120

cacggcacct tcgtgggccg catcgctcag gacctggggc tggagctggc ggagctggtg    180

ccgcgcctgt tccgggtggc gtccaaaaga cacggggacc ttctggaggt aaatctgcag    240

aatggcattt tgtttgtgaa ttctcggatc gaccgcgagg agctgtgtgg gcggagcgcg    300

gagtgcagca tccacctgga ggtgatcgtg gacaggcctc tgcaggtttt ccatgtggag    360

gtgaaggtga gggacattaa cgacaacccg cccatattcc ctgaaagcaa gaaacgaata    420

atcattgcag aatctagacc tccggaaact cgatttccac tagatggcgc atccgatgca    480

gatattggag taaactcggc attgacctac cgactggatc ccaacgatta tttcactttg    540

gacgcacaaa acagtcttga gcaaatgtct tcattatcac ttgtactgag gaaaacactg    600

gacagagagg aaattcagga acatagttta ttactgacag ccagtgatgg aggtaaaccc    660

gagctgactg gcacagttca gctgctcatc acgattctgg acgtgaatga caacgccccg    720

gaattttacc aatccgttta taaagtgacg gtgttagaga acgccttcaa tggaacatta    780

gtgatcaagc taaatgccac agatcctgat gatggtacaa atggagatat agtttactca    840

tttagaaggc ctgtatggcc tgcagtggta tatgcattta ccataaatcc gaacaatgga    900

gaaattagga caaaaggcaa actagatttc gaagaaaaga aattatatga aatatccgtg    960

gaggcagttg acaaaggaaa tattccaatg gcgggtcatt gtaccctttt ggtggaagta   1020

ctagatgtaa atgataacgc cccagaggtt accatcactt ctttgtcact ccccatcaga   1080

gaagacactc agcctagcgc cattattgcc ctaatcagtg tgtccgatcg tgactctggc   1140

tcaaatggac aggtcacctg caccttgacg ccgcatgtcc ccttcaagct ggtgtccacc   1200

tacaagaact actactcatt agtgctggac agcgccctgg accgcgagag cgtatcagcc   1260

tatgaactgg tggtgaccgc gcgggacggg ggctcgcctt cgctgtgggc cacggccagc   1320

gtgtcggtgg gggtggccga cgtgaacgac aacgcgccgg cgttcgcgca gcccgagtac   1380

acggtgttcg tgaaggaaaa caatccgccg ggctgccaca tcttcacggt gtctgctcag   1440

gacgcggacg cacaggagaa cgcgctggtc tcctactcgc tggtggagcg gcgggtgggc   1500

gagcgtgcgc tgtcgagcta cgtgtcggtg cacgcggaga gcggcaaggt gtacgcgctg   1560

cagccgttgg accacgagga gctggagctg ttgcagttcc aggtgagcgc gcgcgactct   1620

ggcgtgccgc ctctgggcag caacgtgacg ctgcaggtgt tcgtgctgga cgagaacgac   1680

aacgctccgg cgctgctgac gcccggggct ggcagcgcgg gaggcacagt gagcgagctg   1740

atgccgcggt cggtgggtgc aggccacgtg gtggcgaagg tgcgcgcggt ggacgccgat   1800

tcgggctaca atgcgtggct ttcgtatgaa ttgcagctgg cggcggtcgg cgcgcgcatc   1860

ccgttccgcg tggggctgta cactggcgag atcagcacga cgcgccctct ggacgaggtg   1920

gacgcgccgc accaccgcct tctggtgctg gtgaaggacc acggtgagcc cgcgctgacg   1980

gccacggcaa cggtgctgtt gtcgctggtg gagagcggcc aagcgccaca ggcttcgtcg   2040

agggcgtcgg caggcgctgt gggtccagaa gcggcgctgg tggatgtcaa tgtttacttg   2100

atcattgcca tctgcgcggt gtccagcctg ttggtgctca cgttgctgct gtatactgcg   2160

ctgcggtgct cggcaccgcc caccgagggc gcgtgcgcgc cgggcaagcc cactctagtg   2220

tgctccagcg cggcagggag ttggtcgtac tcgcagcaga ggcggccgag ggtgtgctct   2280

ggggagggcc cgcataagac ggacctcatg gccttcagtc ccagccttcc tccttgtctg   2340

ggttctgcag agggaacagg ccagagggag gaggactcag aatgcttgaa agagccacga   2400

cagcccaacc ctgactggcg ttactctgcc tccctgagag caggcatgca cagctctgtg   2460

cacctagagg aggctggcat tctacgggct ggtccaggag ggcctgatca gcagtggcca   2520

acagtatcca gtgcaacacc agaaccagag gcaggagaag tgtcccctcc agtcggtgcg   2580

ggtgtcaaca gcaacagctg gacctttaaa tacggaccag gcaaccccaa acaatccggt   2640

cccggtgagt tgcccgacaa attcattatc ccaggatctc ctgcaatcat ctccatccgg   2700

caggagccta ctaacagcca aattgacaaa agtgacttca taaccttcgg caaaaaggag   2760

gagaccaaga aaaagaagaa aaagaagaag ggtaacaaga cccaggagaa aaaagagaaa   2820

gggaacagca cgactgacaa cagtgaccag tgaggtcctc aaatggaaac aagccactta   2880

gccagttttt gtaataatgg caaatctctc ccatgtagca attccctgct cctttttcct   2940

atctacatga gccctcttag agacctcaga aatctgcaga aagttccctg tgtctgtcta   3000

gaacgcattt aacaggtttt gtcgtaaaag ctttactaag tctggtgtta actctttctc   3060

tccactctgg cttgttttca gaacctaaaa agcagaccca agtttccttt ctcctccgcc   3120

gcaaaggaga ggcttcccag ccccgccagt gagaggttgg actctctgcc ctgtgctccg   3180

gggatcctgt cttgatgaca cttgcagggc aggctgaaaa gttttgagat tgagcagctt   3240

gggagtttgt ggccactggg tatgtgtggc taccgcgggt atgcgagtgc cagatattgg   3300

ctgagacgag ccagcttaga ctaattggta caaggaaggc aagaaaacaa agacaaataa   3360

acagcggaag ttatcagtat ggaggggaag tgtaaactta aagggaccag actttctaaa   3420

tcttacaact caagaggtgg cagccaccct ctaggagaca aaactacccc cactgacaag   3480

gctttaggag accctaaagt ctgttggctg tgacgtcatt atacctaaaa tctgcatcat   3540

acctgcaagc caacagttca gtgttttaac agagaaccac cctgggaaac agaagcagat   3600

ctgatgtgtt tcctatacat gtcctgtgct cactttatta aaaattcttt tgcacacaat   3660

gtttatgaaa aggccagatc cttttccaat acttatgcaa aagcaaaaga aaaccccgac   3720

acctcacctt tcgctgtttg ttgtttcata gatttattta aaaaaagaga aagtctatag   3780

ctataaatct ttaaagagaa atatgaatac aattccccta aactctcctc aaaagagaat   3840

tcagtctaca gccatttaaa tgatcattgc tgctacagaa gtgctttaag agaattgcct   3900

gaaacatctg tattatatcg gccacctgcc aatcacagct ttactctttc aggtcactct   3960

ggggctgcct cttgcatgta ttactaaata aaatgatctc tctttctctc tctctctctc   4020

ttttctaaga aacaattatg tgcactttga tacacaacct tctctaacca actatatatc   4080

aagacccaaa aattgaagaa aaatattgtt ttctcataca gtgagcagat ttttcaatct   4140

actaattctg tgacttgtct tggtgtgcta gcctacacct tctctttggt ttagttttcc   4200

ttttctataa cactctgaat tgctaatctt actaacacct atgatgttac ctgaaatcaa   4260

tctcccatat gtatgctgta tgctatgcta agactcctga aatatactta ctctgtgctt   4320

gtgtatgtga atgttaatgc aactattacc tagagtgaac tttaagcttt attgttgaat   4380

gtaattccat tatatttcct tttgtacacc tgtgaaaaag tggagtagtg tttttttaac   4440

cattgttaat cagcttttgt gtatgaaaga cacagtaaaa tttctttctt aaatcaagat   4500

actggtgatt caaggaattt tatttatggt ccagccaaga gccatctcgt gccaagactt   4560

ctgctggcaa gggaatggat aaagctgttt tgttctagta acaattttgg aatgaatact   4620

gacaatattc catgagggtg tgcaagcaca aattttacca atctgacctc tttgaagttg   4680

cagaatgctt tgaaattcta atggtatctg aaatatcagc tcatagaaag taacaaaatt   4740

tgctgtcacc ttaaataaga cattttaatt ttgttataat gtacaattta gaagtttgat   4800

taattatatt atctatttag gcattaatat aaaagaggta ggagtctgtt atttaaaaaa   4860

agcattaaat ttaaaaaaaa actgtcttgt ctacttttag cttcattctc ccatattttg   4920

aagggtgtgt aacttcagct ctgcaggatt gcatggggta aaacttgtta ccaacacatg   4980

tgaaccattg ctacattgta ggttgtgatc attttgcccc actgaagccc atgtatctga   5040

ccttacgtgc cttttgaact aggagaatcg ggctaattta ttaatgatga taattataat   5100

gtatctgtac agcacttttt acatttgcga agtgctttcc aatccatgtt agttactagt   5160

tattacagct gtaaggataa aacacgtcat gtggattcat tttgaattgg tgctattggt   5220

atttcctctg ttattgctaa taaatgaaaa tggtggtatg                         5260


<210>  262
<211>  950
<212>  PRT
<213>  Homo sapiens

<400>  262


Met Leu Ser Ser Trp Gln Gly Gly Pro Arg Pro Arg Gln Leu Leu Leu 
1               5                   10                  15      


Trp Leu Leu Ile Leu Ala Ala Trp Glu Thr Gly Ser Gly Gln Leu His 
            20                  25                  30          


Tyr Ser Val Pro Glu Glu Ala Lys His Gly Thr Phe Val Gly Arg Ile 
        35                  40                  45              


Ala Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Pro Arg Leu Phe 
    50                  55                  60                  


Arg Val Ala Ser Lys Arg His Gly Asp Leu Leu Glu Val Asn Leu Gln 
65                  70                  75                  80  


Asn Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Gly Arg Ser Ala Glu Cys Ser Ile His Leu Glu Val Ile Val Asp Arg 
            100                 105                 110         


Pro Leu Gln Val Phe His Val Glu Val Lys Val Arg Asp Ile Asn Asp 
        115                 120                 125             


Asn Pro Pro Ile Phe Pro Glu Ser Lys Lys Arg Ile Ile Ile Ala Glu 
    130                 135                 140                 


Ser Arg Pro Pro Glu Thr Arg Phe Pro Leu Asp Gly Ala Ser Asp Ala 
145                 150                 155                 160 


Asp Ile Gly Val Asn Ser Ala Leu Thr Tyr Arg Leu Asp Pro Asn Asp 
                165                 170                 175     


Tyr Phe Thr Leu Asp Ala Gln Asn Ser Leu Glu Gln Met Ser Ser Leu 
            180                 185                 190         


Ser Leu Val Leu Arg Lys Thr Leu Asp Arg Glu Glu Ile Gln Glu His 
        195                 200                 205             


Ser Leu Leu Leu Thr Ala Ser Asp Gly Gly Lys Pro Glu Leu Thr Gly 
    210                 215                 220                 


Thr Val Gln Leu Leu Ile Thr Ile Leu Asp Val Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Glu Phe Tyr Gln Ser Val Tyr Lys Val Thr Val Leu Glu Asn Ala Phe 
                245                 250                 255     


Asn Gly Thr Leu Val Ile Lys Leu Asn Ala Thr Asp Pro Asp Asp Gly 
            260                 265                 270         


Thr Asn Gly Asp Ile Val Tyr Ser Phe Arg Arg Pro Val Trp Pro Ala 
        275                 280                 285             


Val Val Tyr Ala Phe Thr Ile Asn Pro Asn Asn Gly Glu Ile Arg Thr 
    290                 295                 300                 


Lys Gly Lys Leu Asp Phe Glu Glu Lys Lys Leu Tyr Glu Ile Ser Val 
305                 310                 315                 320 


Glu Ala Val Asp Lys Gly Asn Ile Pro Met Ala Gly His Cys Thr Leu 
                325                 330                 335     


Leu Val Glu Val Leu Asp Val Asn Asp Asn Ala Pro Glu Val Thr Ile 
            340                 345                 350         


Thr Ser Leu Ser Leu Pro Ile Arg Glu Asp Thr Gln Pro Ser Ala Ile 
        355                 360                 365             


Ile Ala Leu Ile Ser Val Ser Asp Arg Asp Ser Gly Ser Asn Gly Gln 
    370                 375                 380                 


Val Thr Cys Thr Leu Thr Pro His Val Pro Phe Lys Leu Val Ser Thr 
385                 390                 395                 400 


Tyr Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu 
                405                 410                 415     


Ser Val Ser Ala Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser 
            420                 425                 430         


Pro Ser Leu Trp Ala Thr Ala Ser Val Ser Val Gly Val Ala Asp Val 
        435                 440                 445             


Asn Asp Asn Ala Pro Ala Phe Ala Gln Pro Glu Tyr Thr Val Phe Val 
    450                 455                 460                 


Lys Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Gln 
465                 470                 475                 480 


Asp Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu 
                485                 490                 495     


Arg Arg Val Gly Glu Arg Ala Leu Ser Ser Tyr Val Ser Val His Ala 
            500                 505                 510         


Glu Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu 
        515                 520                 525             


Glu Leu Leu Gln Phe Gln Val Ser Ala Arg Asp Ser Gly Val Pro Pro 
    530                 535                 540                 


Leu Gly Ser Asn Val Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp 
545                 550                 555                 560 


Asn Ala Pro Ala Leu Leu Thr Pro Gly Ala Gly Ser Ala Gly Gly Thr 
                565                 570                 575     


Val Ser Glu Leu Met Pro Arg Ser Val Gly Ala Gly His Val Val Ala 
            580                 585                 590         


Lys Val Arg Ala Val Asp Ala Asp Ser Gly Tyr Asn Ala Trp Leu Ser 
        595                 600                 605             


Tyr Glu Leu Gln Leu Ala Ala Val Gly Ala Arg Ile Pro Phe Arg Val 
    610                 615                 620                 


Gly Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Pro Leu Asp Glu Val 
625                 630                 635                 640 


Asp Ala Pro His His Arg Leu Leu Val Leu Val Lys Asp His Gly Glu 
                645                 650                 655     


Pro Ala Leu Thr Ala Thr Ala Thr Val Leu Leu Ser Leu Val Glu Ser 
            660                 665                 670         


Gly Gln Ala Pro Gln Ala Ser Ser Arg Ala Ser Ala Gly Ala Val Gly 
        675                 680                 685             


Pro Glu Ala Ala Leu Val Asp Val Asn Val Tyr Leu Ile Ile Ala Ile 
    690                 695                 700                 


Cys Ala Val Ser Ser Leu Leu Val Leu Thr Leu Leu Leu Tyr Thr Ala 
705                 710                 715                 720 


Leu Arg Cys Ser Ala Pro Pro Thr Glu Gly Ala Cys Ala Pro Gly Lys 
                725                 730                 735     


Pro Thr Leu Val Cys Ser Ser Ala Ala Gly Ser Trp Ser Tyr Ser Gln 
            740                 745                 750         


Gln Arg Arg Pro Arg Val Cys Ser Gly Glu Gly Pro His Lys Thr Asp 
        755                 760                 765             


Leu Met Ala Phe Ser Pro Ser Leu Pro Pro Cys Leu Gly Ser Ala Glu 
    770                 775                 780                 


Gly Thr Gly Gln Arg Glu Glu Asp Ser Glu Cys Leu Lys Glu Pro Arg 
785                 790                 795                 800 


Gln Pro Asn Pro Asp Trp Arg Tyr Ser Ala Ser Leu Arg Ala Gly Met 
                805                 810                 815     


His Ser Ser Val His Leu Glu Glu Ala Gly Ile Leu Arg Ala Gly Pro 
            820                 825                 830         


Gly Gly Pro Asp Gln Gln Trp Pro Thr Val Ser Ser Ala Thr Pro Glu 
        835                 840                 845             


Pro Glu Ala Gly Glu Val Ser Pro Pro Val Gly Ala Gly Val Asn Ser 
    850                 855                 860                 


Asn Ser Trp Thr Phe Lys Tyr Gly Pro Gly Asn Pro Lys Gln Ser Gly 
865                 870                 875                 880 


Pro Gly Glu Leu Pro Asp Lys Phe Ile Ile Pro Gly Ser Pro Ala Ile 
                885                 890                 895     


Ile Ser Ile Arg Gln Glu Pro Thr Asn Ser Gln Ile Asp Lys Ser Asp 
            900                 905                 910         


Phe Ile Thr Phe Gly Lys Lys Glu Glu Thr Lys Lys Lys Lys Lys Lys 
        915                 920                 925             


Lys Lys Gly Asn Lys Thr Gln Glu Lys Lys Glu Lys Gly Asn Ser Thr 
    930                 935                 940                 


Thr Asp Asn Ser Asp Gln 
945                 950 

<210>  263
<211>  2427
<212>  DNA
<213>  Homo sapiens

<400>  263
atgctgtctt cctggcaagg aggcccaaga ccgcggcaac tactgctctg gcttctgatc     60

ctcgcagcct gggagacggg tagtggccag ctccactact ccgtccccga ggaagcaaaa    120

cacggcacct tcgtgggccg catcgctcag gacctggggc tggagctggc ggagctggtg    180

ccgcgcctgt tccgggtggc gtccaaaaga cacggggacc ttctggaggt aaatctgcag    240

aatggcattt tgtttgtgaa ttctcggatc gaccgcgagg agctgtgtgg gcggagcgcg    300

gagtgcagca tccacctgga ggtgatcgtg gacaggcctc tgcaggtttt ccatgtggag    360

gtgaaggtga gggacattaa cgacaacccg cccatattcc ctgaaagcaa gaaacgaata    420

atcattgcag aatctagacc tccggaaact cgatttccac tagatggcgc atccgatgca    480

gatattggag taaactcggc attgacctac cgactggatc ccaacgatta tttcactttg    540

gacgcacaaa acagtcttga gcaaatgtct tcattatcac ttgtactgag gaaaacactg    600

gacagagagg aaattcagga acatagttta ttactgacag ccagtgatgg aggtaaaccc    660

gagctgactg gcacagttca gctgctcatc acgattctgg acgtgaatga caacgccccg    720

gaattttacc aatccgttta taaagtgacg gtgttagaga acgccttcaa tggaacatta    780

gtgatcaagc taaatgccac agatcctgat gatggtacaa atggagatat agtttactca    840

tttagaaggc ctgtatggcc tgcagtggta tatgcattta ccataaatcc gaacaatgga    900

gaaattagga caaaaggcaa actagatttc gaagaaaaga aattatatga aatatccgtg    960

gaggcagttg acaaaggaaa tattccaatg gcgggtcatt gtaccctttt ggtggaagta   1020

ctagatgtaa atgataacgc cccagaggtt accatcactt ctttgtcact ccccatcaga   1080

gaagacactc agcctagcgc cattattgcc ctaatcagtg tgtccgatcg tgactctggc   1140

tcaaatggac aggtcacctg caccttgacg ccgcatgtcc ccttcaagct ggtgtccacc   1200

tacaagaact actactcatt agtgctggac agcgccctgg accgcgagag cgtatcagcc   1260

tatgaactgg tggtgaccgc gcgggacggg ggctcgcctt cgctgtgggc cacggccagc   1320

gtgtcggtgg gggtggccga cgtgaacgac aacgcgccgg cgttcgcgca gcccgagtac   1380

acggtgttcg tgaaggaaaa caatccgccg ggctgccaca tcttcacggt gtctgctcag   1440

gacgcggacg cacaggagaa cgcgctggtc tcctactcgc tggtggagcg gcgggtgggc   1500

gagcgtgcgc tgtcgagcta cgtgtcggtg cacgcggaga gcggcaaggt gtacgcgctg   1560

cagccgttgg accacgagga gctggagctg ttgcagttcc aggtgagcgc gcgcgactct   1620

ggcgtgccgc ctctgggcag caacgtgacg ctgcaggtgt tcgtgctgga cgagaacgac   1680

aacgctccgg cgctgctgac gcccggggct ggcagcgcgg gaggcacagt gagcgagctg   1740

atgccgcggt cggtgggtgc aggccacgtg gtggcgaagg tgcgcgcggt ggacgccgat   1800

tcgggctaca atgcgtggct ttcgtatgaa ttgcagctgg cggcggtcgg cgcgcgcatc   1860

ccgttccgcg tggggctgta cactggcgag atcagcacga cgcgccctct ggacgaggtg   1920

gacgcgccgc accaccgcct tctggtgctg gtgaaggacc acggtgagcc cgcgctgacg   1980

gccacggcaa cggtgctgtt gtcgctggtg gagagcggcc aagcgccaca ggcttcgtcg   2040

agggcgtcgg caggcgctgt gggtccagaa gcggcgctgg tggatgtcaa tgtttacttg   2100

atcattgcca tctgcgcggt gtccagcctg ttggtgctca cgttgctgct gtatactgcg   2160

ctgcggtgct cggcaccgcc caccgagggc gcgtgcgcgc cgggcaagcc cactctagtg   2220

tgctccagcg cggcagggag ttggtcgtac tcgcagcaga ggcggccgag ggtgtgctct   2280

ggggagggcc cgcataagac ggacctcatg gccttcagtc ccagccttcc tccttgtctg   2340

ggttctgcag agggaacagg ccagagggag gaggactcag aatgcttgaa agaggtaagc   2400

ttatatttta aaaaattgtc ttagtaa                                       2427


<210>  264
<211>  807
<212>  PRT
<213>  Homo sapiens

<400>  264


Met Leu Ser Ser Trp Gln Gly Gly Pro Arg Pro Arg Gln Leu Leu Leu 
1               5                   10                  15      


Trp Leu Leu Ile Leu Ala Ala Trp Glu Thr Gly Ser Gly Gln Leu His 
            20                  25                  30          


Tyr Ser Val Pro Glu Glu Ala Lys His Gly Thr Phe Val Gly Arg Ile 
        35                  40                  45              


Ala Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Pro Arg Leu Phe 
    50                  55                  60                  


Arg Val Ala Ser Lys Arg His Gly Asp Leu Leu Glu Val Asn Leu Gln 
65                  70                  75                  80  


Asn Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Gly Arg Ser Ala Glu Cys Ser Ile His Leu Glu Val Ile Val Asp Arg 
            100                 105                 110         


Pro Leu Gln Val Phe His Val Glu Val Lys Val Arg Asp Ile Asn Asp 
        115                 120                 125             


Asn Pro Pro Ile Phe Pro Glu Ser Lys Lys Arg Ile Ile Ile Ala Glu 
    130                 135                 140                 


Ser Arg Pro Pro Glu Thr Arg Phe Pro Leu Asp Gly Ala Ser Asp Ala 
145                 150                 155                 160 


Asp Ile Gly Val Asn Ser Ala Leu Thr Tyr Arg Leu Asp Pro Asn Asp 
                165                 170                 175     


Tyr Phe Thr Leu Asp Ala Gln Asn Ser Leu Glu Gln Met Ser Ser Leu 
            180                 185                 190         


Ser Leu Val Leu Arg Lys Thr Leu Asp Arg Glu Glu Ile Gln Glu His 
        195                 200                 205             


Ser Leu Leu Leu Thr Ala Ser Asp Gly Gly Lys Pro Glu Leu Thr Gly 
    210                 215                 220                 


Thr Val Gln Leu Leu Ile Thr Ile Leu Asp Val Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Glu Phe Tyr Gln Ser Val Tyr Lys Val Thr Val Leu Glu Asn Ala Phe 
                245                 250                 255     


Asn Gly Thr Leu Val Ile Lys Leu Asn Ala Thr Asp Pro Asp Asp Gly 
            260                 265                 270         


Thr Asn Gly Asp Ile Val Tyr Ser Phe Arg Arg Pro Val Trp Pro Ala 
        275                 280                 285             


Val Val Tyr Ala Phe Thr Ile Asn Pro Asn Asn Gly Glu Ile Arg Thr 
    290                 295                 300                 


Lys Gly Lys Leu Asp Phe Glu Glu Lys Lys Leu Tyr Glu Ile Ser Val 
305                 310                 315                 320 


Glu Ala Val Asp Lys Gly Asn Ile Pro Met Ala Gly His Cys Thr Leu 
                325                 330                 335     


Leu Val Glu Val Leu Asp Val Asn Asp Asn Ala Pro Glu Val Thr Ile 
            340                 345                 350         


Thr Ser Leu Ser Leu Pro Ile Arg Glu Asp Thr Gln Pro Ser Ala Ile 
        355                 360                 365             


Ile Ala Leu Ile Ser Val Ser Asp Arg Asp Ser Gly Ser Asn Gly Gln 
    370                 375                 380                 


Val Thr Cys Thr Leu Thr Pro His Val Pro Phe Lys Leu Val Ser Thr 
385                 390                 395                 400 


Tyr Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu 
                405                 410                 415     


Ser Val Ser Ala Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser 
            420                 425                 430         


Pro Ser Leu Trp Ala Thr Ala Ser Val Ser Val Gly Val Ala Asp Val 
        435                 440                 445             


Asn Asp Asn Ala Pro Ala Phe Ala Gln Pro Glu Tyr Thr Val Phe Val 
    450                 455                 460                 


Lys Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Gln 
465                 470                 475                 480 


Asp Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu 
                485                 490                 495     


Arg Arg Val Gly Glu Arg Ala Leu Ser Ser Tyr Val Ser Val His Ala 
            500                 505                 510         


Glu Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu 
        515                 520                 525             


Glu Leu Leu Gln Phe Gln Val Ser Ala Arg Asp Ser Gly Val Pro Pro 
    530                 535                 540                 


Leu Gly Ser Asn Val Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp 
545                 550                 555                 560 


Asn Ala Pro Ala Leu Leu Thr Pro Gly Ala Gly Ser Ala Gly Gly Thr 
                565                 570                 575     


Val Ser Glu Leu Met Pro Arg Ser Val Gly Ala Gly His Val Val Ala 
            580                 585                 590         


Lys Val Arg Ala Val Asp Ala Asp Ser Gly Tyr Asn Ala Trp Leu Ser 
        595                 600                 605             


Tyr Glu Leu Gln Leu Ala Ala Val Gly Ala Arg Ile Pro Phe Arg Val 
    610                 615                 620                 


Gly Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Pro Leu Asp Glu Val 
625                 630                 635                 640 


Asp Ala Pro His His Arg Leu Leu Val Leu Val Lys Asp His Gly Glu 
                645                 650                 655     


Pro Ala Leu Thr Ala Thr Ala Thr Val Leu Leu Ser Leu Val Glu Ser 
            660                 665                 670         


Gly Gln Ala Pro Gln Ala Ser Ser Arg Ala Ser Ala Gly Ala Val Gly 
        675                 680                 685             


Pro Glu Ala Ala Leu Val Asp Val Asn Val Tyr Leu Ile Ile Ala Ile 
    690                 695                 700                 


Cys Ala Val Ser Ser Leu Leu Val Leu Thr Leu Leu Leu Tyr Thr Ala 
705                 710                 715                 720 


Leu Arg Cys Ser Ala Pro Pro Thr Glu Gly Ala Cys Ala Pro Gly Lys 
                725                 730                 735     


Pro Thr Leu Val Cys Ser Ser Ala Ala Gly Ser Trp Ser Tyr Ser Gln 
            740                 745                 750         


Gln Arg Arg Pro Arg Val Cys Ser Gly Glu Gly Pro His Lys Thr Asp 
        755                 760                 765             


Leu Met Ala Phe Ser Pro Ser Leu Pro Pro Cys Leu Gly Ser Ala Glu 
    770                 775                 780                 


Gly Thr Gly Gln Arg Glu Glu Asp Ser Glu Cys Leu Lys Glu Val Ser 
785                 790                 795                 800 


Leu Tyr Phe Lys Lys Leu Ser 
                805         

<210>  265
<211>  5475
<212>  DNA
<213>  Homo sapiens

<400>  265
caatgccggc gttcgggagg cgcaacgtcg gcggtcgctg agtatccagc ccgcagcagt     60

gacggccggc aggagcgtgc tcttccccgc ggctcgtgct ctccaggagt ccggagcatg    120

gtcctgggtc accgttggtg tagcgtgttg gtggaacgtg gacgcctaga gggaggatgg    180

tgggctgtgg ggtggcagtt ttatgtttgt gggtttcctg cggcgctgca gcgggacagc    240

tcgagtactc agtgccggag gagacggagc ggggcgtagc cgtaggcaat ctctccgcgg    300

acttgaggct gccagcggcc gctatgtcct cgcggaactt tcgcttcctt tccagccacc    360

gcgagctcta cttcggggtg gatctaccca gcggcaattt ggtggtcaga gagccggcgg    420

accgcgaaca gctgtgcagg gccaaagctg cctgcgtctt gacctacgac ctggtgctcg    480

aggacccgct ggagctgcac aagattcgga ttcacgtcct ggacaccaat gacaactcac    540

ctctctttcc tgccggcgac gtgcagctgc acatccccga gttcctgacg cccggagccc    600

gctttactct cccgaatgcc caagatgacg acgagggaag caatgggata ctaagctaca    660

gcctaagccc cagtcagcac tttcgcctgg acatgggatc gcgggttgac ggcagcgaat    720

acccggagtt ggtgttggag aaagcactgg atcgcgaaca gcgcgccacc cacctgctgg    780

tgcttacagc tcgggacggc gggctacctg cccgctcagg agacgcacaa gtcaccatca    840

ttgtggtgga cacaaatgac aacgcgcctg tatttgagcg ctccgtatac cgcaccaagg    900

ttccagagac tgcacccaat gggactgtgt tattccgagt tcaagccttg gatccagatg    960

aagggtccaa tggggaagtc cagtactccc taagcaacag cacgcaagca gagctgcgac   1020

accgctttca cgtgcaccct aaaagtgggg aggtgcaagt agctgcttca ctaggtccgc   1080

ctgaaacgct cttggaggca tacattgagg cgagggacga aggtgtcttt ggtttagcta   1140

gcaccgctaa actgctggtg gaggtgactg acgtgaacga tcatgccccc gaactggact   1200

tcctgactct ttcgaaccca gtacctgagg acgctgcccc tggcacagtg attgctctct   1260

ttagtgtaaa ggatgaagac ctcgattcta atggtagggt catttgtggc atgtctagtg   1320

caggcccttt tcagctgacg gcttcctttg acaactacta cagcctgctg attgatgggc   1380

ccctggaccg ggagcagatc agtgaatacc aagtcctgat cacggcctca gatagtggct   1440

cacccccact tagcacccga aggacaatca ctgtgtcagt tgctgatgtg aatgacaata   1500

caccaaactt tcctcaaccc cagcaggaac ttttcgttgc tgaaaacaat ggccctgggg   1560

cctctctagg ccgagtgttt gcccaggacc ccgacctggg gaagaatggc cttgtctctt   1620

atgagctgtt ggatgttatc tctgaagggc catcagcctc tagcttgctg gcagtggaat   1680

catccagtgg ggccatcact gccaaaactt cctttgactt tgagcagctc agggggtttc   1740

atttccaagt agaaggccgg gatggtggca ttcctcccag aagtgcaaca gtgactataa   1800

acttgtttgt ggtagatagg aatgacaatt atccggttat cttgtttccc ttgcccagaa   1860

atggttctgt cccagtggaa attgtgcccc gctctgccag gactggacac ttggtcacaa   1920

aagtggtagc agaggatgct gacagtggtt ctaatgcctg gctttcctac cacatctccc   1980

gggcgtctga ctctagtctc tttagaattt cagccaatat aggtgagctc cgtactgctc   2040

gcttagttct tcccactgat gcagttaagc agagggtggt ggtagtggtt cgggaccatg   2100

gagacccacc actttcctcc tctgtcactc tgggtgtgct gttgagcaac tctgtccctc   2160

agttacttcc agactttgaa gatgtctggg aaccaggagg gcagctttct gcccagaact   2220

tgtatttagt aattgccttg gcttgtattt cctttttatt tctggggtgc ttacttttct   2280

tcgtgtgtac caagttgcac cagagcccag gctgttgcgc tcagagctgc tgtcgctcta   2340

cagaggatct gaggtatgga agtaagatgg tttcaaatcc ttgcatgaca tcagccacca   2400

tagatgtcac tacagttgag agactttctc agacttatct ctatcgggcc tctctgggac   2460

ttggttctga taataacagt ttgctgttgc gtggggagta caatgctgcc gacctgcgaa   2520

atcttgccac tggggtagga ctgaatttgc caatatcctg tattcagatt cggaatagga   2580

aaggggatca cgctaatgtc aatgccatgc cacgacagcc caaccctgac tggcgttact   2640

ctgcctccct gagagcaggc atgcacagct ctgtgcacct agaggaggct ggcattctac   2700

gggctggtcc aggagggcct gatcagcagt ggccaacagt atccagtgca acaccagaac   2760

cagaggcagg agaagtgtcc cctccagtcg gtgcgggtgt caacagcaac agctggacct   2820

ttaaatacgg accaggcaac cccaaacaat ccggtcccgg tgagttgccc gacaaattca   2880

ttatcccagg atctcctgca atcatctcca tccggcagga gcctactaac agccaaattg   2940

acaaaagtga cttcataacc ttcggcaaaa aggaggagac caagaaaaag aagaaaaaga   3000

agaagggtaa caagacccag gagaaaaaag agaaagggaa cagcacgact gacaacagtg   3060

accagtgagg tcctcaaatg gaaacaagcc acttagccag tttttgtaat aatggcaaat   3120

ctctcccatg tagcaattcc ctgctccttt ttcctatcta catgagccct cttagagacc   3180

tcagaaatct gcagaaagtt ccctgtgtct gtctagaacg catttaacag gttttgtcgt   3240

aaaagcttta ctaagtctgg tgttaactct ttctctccac tctggcttgt tttcagaacc   3300

taaaaagcag acccaagttt cctttctcct ccgccgcaaa ggagaggctt cccagccccg   3360

ccagtgagag gttggactct ctgccctgtg ctccggggat cctgtcttga tgacacttgc   3420

agggcaggct gaaaagtttt gagattgagc agcttgggag tttgtggcca ctgggtatgt   3480

gtggctaccg cgggtatgcg agtgccagat attggctgag acgagccagc ttagactaat   3540

tggtacaagg aaggcaagaa aacaaagaca aataaacagc ggaagttatc agtatggagg   3600

ggaagtgtaa acttaaaggg accagacttt ctaaatctta caactcaaga ggtggcagcc   3660

accctctagg agacaaaact acccccactg acaaggcttt aggagaccct aaagtctgtt   3720

ggctgtgacg tcattatacc taaaatctgc atcatacctg caagccaaca gttcagtgtt   3780

ttaacagaga accaccctgg gaaacagaag cagatctgat gtgtttccta tacatgtcct   3840

gtgctcactt tattaaaaat tcttttgcac acaatgttta tgaaaaggcc agatcctttt   3900

ccaatactta tgcaaaagca aaagaaaacc ccgacacctc acctttcgct gtttgttgtt   3960

tcatagattt atttaaaaaa agagaaagtc tatagctata aatctttaaa gagaaatatg   4020

aatacaattc ccctaaactc tcctcaaaag agaattcagt ctacagccat ttaaatgatc   4080

attgctgcta cagaagtgct ttaagagaat tgcctgaaac atctgtatta tatcggccac   4140

ctgccaatca cagctttact ctttcaggtc actctggggc tgcctcttgc atgtattact   4200

aaataaaatg atctctcttt ctctctctct ctctcttttc taagaaacaa ttatgtgcac   4260

tttgatacac aaccttctct aaccaactat atatcaagac ccaaaaattg aagaaaaata   4320

ttgttttctc atacagtgag cagatttttc aatctactaa ttctgtgact tgtcttggtg   4380

tgctagccta caccttctct ttggtttagt tttccttttc tataacactc tgaattgcta   4440

atcttactaa cacctatgat gttacctgaa atcaatctcc catatgtatg ctgtatgcta   4500

tgctaagact cctgaaatat acttactctg tgcttgtgta tgtgaatgtt aatgcaacta   4560

ttacctagag tgaactttaa gctttattgt tgaatgtaat tccattatat ttccttttgt   4620

acacctgtga aaaagtggag tagtgttttt ttaaccattg ttaatcagct tttgtgtatg   4680

aaagacacag taaaatttct ttcttaaatc aagatactgg tgattcaagg aattttattt   4740

atggtccagc caagagccat ctcgtgccaa gacttctgct ggcaagggaa tggataaagc   4800

tgttttgttc tagtaacaat tttggaatga atactgacaa tattccatga gggtgtgcaa   4860

gcacaaattt taccaatctg acctctttga agttgcagaa tgctttgaaa ttctaatggt   4920

atctgaaata tcagctcata gaaagtaaca aaatttgctg tcaccttaaa taagacattt   4980

taattttgtt ataatgtaca atttagaagt ttgattaatt atattatcta tttaggcatt   5040

aatataaaag aggtaggagt ctgttattta aaaaaagcat taaatttaaa aaaaaactgt   5100

cttgtctact tttagcttca ttctcccata ttttgaaggg tgtgtaactt cagctctgca   5160

ggattgcatg gggtaaaact tgttaccaac acatgtgaac cattgctaca ttgtaggttg   5220

tgatcatttt gccccactga agcccatgta tctgacctta cgtgcctttt gaactaggag   5280

aatcgggcta atttattaat gatgataatt ataatgtatc tgtacagcac tttttacatt   5340

tgcgaagtgc tttccaatcc atgttagtta ctagttatta cagctgtaag gataaaacac   5400

gtcatgtgga ttcattttga attggtgcta ttggtatttc ctctgttatt gctaataaat   5460

gaaaatggtg gtatg                                                    5475


<210>  266
<211>  963
<212>  PRT
<213>  Homo sapiens

<400>  266


Met Val Gly Cys Gly Val Ala Val Leu Cys Leu Trp Val Ser Cys Gly 
1               5                   10                  15      


Ala Ala Ala Gly Gln Leu Glu Tyr Ser Val Pro Glu Glu Thr Glu Arg 
            20                  25                  30          


Gly Val Ala Val Gly Asn Leu Ser Ala Asp Leu Arg Leu Pro Ala Ala 
        35                  40                  45              


Ala Met Ser Ser Arg Asn Phe Arg Phe Leu Ser Ser His Arg Glu Leu 
    50                  55                  60                  


Tyr Phe Gly Val Asp Leu Pro Ser Gly Asn Leu Val Val Arg Glu Pro 
65                  70                  75                  80  


Ala Asp Arg Glu Gln Leu Cys Arg Ala Lys Ala Ala Cys Val Leu Thr 
                85                  90                  95      


Tyr Asp Leu Val Leu Glu Asp Pro Leu Glu Leu His Lys Ile Arg Ile 
            100                 105                 110         


His Val Leu Asp Thr Asn Asp Asn Ser Pro Leu Phe Pro Ala Gly Asp 
        115                 120                 125             


Val Gln Leu His Ile Pro Glu Phe Leu Thr Pro Gly Ala Arg Phe Thr 
    130                 135                 140                 


Leu Pro Asn Ala Gln Asp Asp Asp Glu Gly Ser Asn Gly Ile Leu Ser 
145                 150                 155                 160 


Tyr Ser Leu Ser Pro Ser Gln His Phe Arg Leu Asp Met Gly Ser Arg 
                165                 170                 175     


Val Asp Gly Ser Glu Tyr Pro Glu Leu Val Leu Glu Lys Ala Leu Asp 
            180                 185                 190         


Arg Glu Gln Arg Ala Thr His Leu Leu Val Leu Thr Ala Arg Asp Gly 
        195                 200                 205             


Gly Leu Pro Ala Arg Ser Gly Asp Ala Gln Val Thr Ile Ile Val Val 
    210                 215                 220                 


Asp Thr Asn Asp Asn Ala Pro Val Phe Glu Arg Ser Val Tyr Arg Thr 
225                 230                 235                 240 


Lys Val Pro Glu Thr Ala Pro Asn Gly Thr Val Leu Phe Arg Val Gln 
                245                 250                 255     


Ala Leu Asp Pro Asp Glu Gly Ser Asn Gly Glu Val Gln Tyr Ser Leu 
            260                 265                 270         


Ser Asn Ser Thr Gln Ala Glu Leu Arg His Arg Phe His Val His Pro 
        275                 280                 285             


Lys Ser Gly Glu Val Gln Val Ala Ala Ser Leu Gly Pro Pro Glu Thr 
    290                 295                 300                 


Leu Leu Glu Ala Tyr Ile Glu Ala Arg Asp Glu Gly Val Phe Gly Leu 
305                 310                 315                 320 


Ala Ser Thr Ala Lys Leu Leu Val Glu Val Thr Asp Val Asn Asp His 
                325                 330                 335     


Ala Pro Glu Leu Asp Phe Leu Thr Leu Ser Asn Pro Val Pro Glu Asp 
            340                 345                 350         


Ala Ala Pro Gly Thr Val Ile Ala Leu Phe Ser Val Lys Asp Glu Asp 
        355                 360                 365             


Leu Asp Ser Asn Gly Arg Val Ile Cys Gly Met Ser Ser Ala Gly Pro 
    370                 375                 380                 


Phe Gln Leu Thr Ala Ser Phe Asp Asn Tyr Tyr Ser Leu Leu Ile Asp 
385                 390                 395                 400 


Gly Pro Leu Asp Arg Glu Gln Ile Ser Glu Tyr Gln Val Leu Ile Thr 
                405                 410                 415     


Ala Ser Asp Ser Gly Ser Pro Pro Leu Ser Thr Arg Arg Thr Ile Thr 
            420                 425                 430         


Val Ser Val Ala Asp Val Asn Asp Asn Thr Pro Asn Phe Pro Gln Pro 
        435                 440                 445             


Gln Gln Glu Leu Phe Val Ala Glu Asn Asn Gly Pro Gly Ala Ser Leu 
    450                 455                 460                 


Gly Arg Val Phe Ala Gln Asp Pro Asp Leu Gly Lys Asn Gly Leu Val 
465                 470                 475                 480 


Ser Tyr Glu Leu Leu Asp Val Ile Ser Glu Gly Pro Ser Ala Ser Ser 
                485                 490                 495     


Leu Leu Ala Val Glu Ser Ser Ser Gly Ala Ile Thr Ala Lys Thr Ser 
            500                 505                 510         


Phe Asp Phe Glu Gln Leu Arg Gly Phe His Phe Gln Val Glu Gly Arg 
        515                 520                 525             


Asp Gly Gly Ile Pro Pro Arg Ser Ala Thr Val Thr Ile Asn Leu Phe 
    530                 535                 540                 


Val Val Asp Arg Asn Asp Asn Tyr Pro Val Ile Leu Phe Pro Leu Pro 
545                 550                 555                 560 


Arg Asn Gly Ser Val Pro Val Glu Ile Val Pro Arg Ser Ala Arg Thr 
                565                 570                 575     


Gly His Leu Val Thr Lys Val Val Ala Glu Asp Ala Asp Ser Gly Ser 
            580                 585                 590         


Asn Ala Trp Leu Ser Tyr His Ile Ser Arg Ala Ser Asp Ser Ser Leu 
        595                 600                 605             


Phe Arg Ile Ser Ala Asn Ile Gly Glu Leu Arg Thr Ala Arg Leu Val 
    610                 615                 620                 


Leu Pro Thr Asp Ala Val Lys Gln Arg Val Val Val Val Val Arg Asp 
625                 630                 635                 640 


His Gly Asp Pro Pro Leu Ser Ser Ser Val Thr Leu Gly Val Leu Leu 
                645                 650                 655     


Ser Asn Ser Val Pro Gln Leu Leu Pro Asp Phe Glu Asp Val Trp Glu 
            660                 665                 670         


Pro Gly Gly Gln Leu Ser Ala Gln Asn Leu Tyr Leu Val Ile Ala Leu 
        675                 680                 685             


Ala Cys Ile Ser Phe Leu Phe Leu Gly Cys Leu Leu Phe Phe Val Cys 
    690                 695                 700                 


Thr Lys Leu His Gln Ser Pro Gly Cys Cys Ala Gln Ser Cys Cys Arg 
705                 710                 715                 720 


Ser Thr Glu Asp Leu Arg Tyr Gly Ser Lys Met Val Ser Asn Pro Cys 
                725                 730                 735     


Met Thr Ser Ala Thr Ile Asp Val Thr Thr Val Glu Arg Leu Ser Gln 
            740                 745                 750         


Thr Tyr Leu Tyr Arg Ala Ser Leu Gly Leu Gly Ser Asp Asn Asn Ser 
        755                 760                 765             


Leu Leu Leu Arg Gly Glu Tyr Asn Ala Ala Asp Leu Arg Asn Leu Ala 
    770                 775                 780                 


Thr Gly Val Gly Leu Asn Leu Pro Ile Ser Cys Ile Gln Ile Arg Asn 
785                 790                 795                 800 


Arg Lys Gly Asp His Ala Asn Val Asn Ala Met Pro Arg Gln Pro Asn 
                805                 810                 815     


Pro Asp Trp Arg Tyr Ser Ala Ser Leu Arg Ala Gly Met His Ser Ser 
            820                 825                 830         


Val His Leu Glu Glu Ala Gly Ile Leu Arg Ala Gly Pro Gly Gly Pro 
        835                 840                 845             


Asp Gln Gln Trp Pro Thr Val Ser Ser Ala Thr Pro Glu Pro Glu Ala 
    850                 855                 860                 


Gly Glu Val Ser Pro Pro Val Gly Ala Gly Val Asn Ser Asn Ser Trp 
865                 870                 875                 880 


Thr Phe Lys Tyr Gly Pro Gly Asn Pro Lys Gln Ser Gly Pro Gly Glu 
                885                 890                 895     


Leu Pro Asp Lys Phe Ile Ile Pro Gly Ser Pro Ala Ile Ile Ser Ile 
            900                 905                 910         


Arg Gln Glu Pro Thr Asn Ser Gln Ile Asp Lys Ser Asp Phe Ile Thr 
        915                 920                 925             


Phe Gly Lys Lys Glu Glu Thr Lys Lys Lys Lys Lys Lys Lys Lys Gly 
    930                 935                 940                 


Asn Lys Thr Gln Glu Lys Lys Glu Lys Gly Asn Ser Thr Thr Asp Asn 
945                 950                 955                 960 


Ser Asp Gln 
            

<210>  267
<211>  3084
<212>  DNA
<213>  Homo sapiens

<400>  267
caatgccggc gttcgggagg cgcaacgtcg gcggtcgctg agtatccagc ccgcagcagt     60

gacggccggc aggagcgtgc tcttccccgc ggctcgtgct ctccaggagt ccggagcatg    120

gtcctgggtc accgttggtg tagcgtgttg gtggaacgtg gacgcctaga gggaggatgg    180

tgggctgtgg ggtggcagtt ttatgtttgt gggtttcctg cggcgctgca gcgggacagc    240

tcgagtactc agtgccggag gagacggagc ggggcgtagc cgtaggcaat ctctccgcgg    300

acttgaggct gccagcggcc gctatgtcct cgcggaactt tcgcttcctt tccagccacc    360

gcgagctcta cttcggggtg gatctaccca gcggcaattt ggtggtcaga gagccggcgg    420

accgcgaaca gctgtgcagg gccaaagctg cctgcgtctt gacctacgac ctggtgctcg    480

aggacccgct ggagctgcac aagattcgga ttcacgtcct ggacaccaat gacaactcac    540

ctctctttcc tgccggcgac gtgcagctgc acatccccga gttcctgacg cccggagccc    600

gctttactct cccgaatgcc caagatgacg acgagggaag caatgggata ctaagctaca    660

gcctaagccc cagtcagcac tttcgcctgg acatgggatc gcgggttgac ggcagcgaat    720

acccggagtt ggtgttggag aaagcactgg atcgcgaaca gcgcgccacc cacctgctgg    780

tgcttacagc tcgggacggc gggctacctg cccgctcagg agacgcacaa gtcaccatca    840

ttgtggtgga cacaaatgac aacgcgcctg tatttgagcg ctccgtatac cgcaccaagg    900

ttccagagac tgcacccaat gggactgtgt tattccgagt tcaagccttg gatccagatg    960

aagggtccaa tggggaagtc cagtactccc taagcaacag cacgcaagca gagctgcgac   1020

accgctttca cgtgcaccct aaaagtgggg aggtgcaagt agctgcttca ctaggtccgc   1080

ctgaaacgct cttggaggca tacattgagg cgagggacga aggtgtcttt ggtttagcta   1140

gcaccgctaa actgctggtg gaggtgactg acgtgaacga tcatgccccc gaactggact   1200

tcctgactct ttcgaaccca gtacctgagg acgctgcccc tggcacagtg attgctctct   1260

ttagtgtaaa ggatgaagac ctcgattcta atggtagggt catttgtggc atgtctagtg   1320

caggcccttt tcagctgacg gcttcctttg acaactacta cagcctgctg attgatgggc   1380

ccctggaccg ggagcagatc agtgaatacc aagtcctgat cacggcctca gatagtggct   1440

cacccccact tagcacccga aggacaatca ctgtgtcagt tgctgatgtg aatgacaata   1500

caccaaactt tcctcaaccc cagcaggaac ttttcgttgc tgaaaacaat ggccctgggg   1560

cctctctagg ccgagtgttt gcccaggacc ccgacctggg gaagaatggc cttgtctctt   1620

atgagctgtt ggatgttatc tctgaagggc catcagcctc tagcttgctg gcagtggaat   1680

catccagtgg ggccatcact gccaaaactt cctttgactt tgagcagctc agggggtttc   1740

atttccaagt agaaggccgg gatggtggca ttcctcccag aagtgcaaca gtgactataa   1800

acttgtttgt ggtagatagg aatgacaatt atccggttat cttgtttccc ttgcccagaa   1860

atggttctgt cccagtggaa attgtgcccc gctctgccag gactggacac ttggtcacaa   1920

aagtggtagc agaggatgct gacagtggtt ctaatgcctg gctttcctac cacatctccc   1980

gggcgtctga ctctagtctc tttagaattt cagccaatat aggtgagctc cgtactgctc   2040

gcttagttct tcccactgat gcagttaagc agagggtggt ggtagtggtt cgggaccatg   2100

gagacccacc actttcctcc tctgtcactc tgggtgtgct gttgagcaac tctgtccctc   2160

agttacttcc agactttgaa gatgtctggg aaccaggagg gcagctttct gcccagaact   2220

tgtatttagt aattgccttg gcttgtattt cctttttatt tctggggtgc ttacttttct   2280

tcgtgtgtac caagttgcac cagagcccag gctgttgcgc tcagagctgc tgtcgctcta   2340

cagaggatct gaggtatgga agtaagatgg tttcaaatcc ttgcatgaca tcagccacca   2400

tagatgtcac tacagttgag agactttctc agacttatct ctatcgggcc tctctgggac   2460

ttggttctga taataacagt ttgctgttgc gtggggagta caatgctgcc gacctgcgaa   2520

atcttgccac tggggtagga ctgaatttgc caatatcctg tattcagatt cggaatagga   2580

aaggggatca cgctaatgtc aatgccatgg taagcaaatt ttatggaatt tgattccttt   2640

ggcccggaga tggctgctag ctgtgttttg aaatatttct tagacaagcc tttcacaaca   2700

tttcatcaat tgaactaaac actccttctt agcacttcct gtgccaagaa atctggaagt   2760

atagaagtat tagaagattg ccctaggcct caagggactt atagtttatt tttgagaaac   2820

aagggcaaaa attaaaacct atttaagaac aataaaagta atatgacata aaggtctaaa   2880

attaaaaata aaataccaaa atattttata agcaacagat gtgtaaggca ctctaatatt   2940

taaagtgaag aatgaaaaat atgtaagagt ctgctttata tgaatataat atggaaggtg   3000

aaacatttac ttaaactatt gcaatgcatt attaaaagat gacgataacc acaaaagatg   3060

taaaaataaa ttacaatggg ggtt                                          3084


<210>  268
<211>  818
<212>  PRT
<213>  Homo sapiens

<400>  268


Met Val Gly Cys Gly Val Ala Val Leu Cys Leu Trp Val Ser Cys Gly 
1               5                   10                  15      


Ala Ala Ala Gly Gln Leu Glu Tyr Ser Val Pro Glu Glu Thr Glu Arg 
            20                  25                  30          


Gly Val Ala Val Gly Asn Leu Ser Ala Asp Leu Arg Leu Pro Ala Ala 
        35                  40                  45              


Ala Met Ser Ser Arg Asn Phe Arg Phe Leu Ser Ser His Arg Glu Leu 
    50                  55                  60                  


Tyr Phe Gly Val Asp Leu Pro Ser Gly Asn Leu Val Val Arg Glu Pro 
65                  70                  75                  80  


Ala Asp Arg Glu Gln Leu Cys Arg Ala Lys Ala Ala Cys Val Leu Thr 
                85                  90                  95      


Tyr Asp Leu Val Leu Glu Asp Pro Leu Glu Leu His Lys Ile Arg Ile 
            100                 105                 110         


His Val Leu Asp Thr Asn Asp Asn Ser Pro Leu Phe Pro Ala Gly Asp 
        115                 120                 125             


Val Gln Leu His Ile Pro Glu Phe Leu Thr Pro Gly Ala Arg Phe Thr 
    130                 135                 140                 


Leu Pro Asn Ala Gln Asp Asp Asp Glu Gly Ser Asn Gly Ile Leu Ser 
145                 150                 155                 160 


Tyr Ser Leu Ser Pro Ser Gln His Phe Arg Leu Asp Met Gly Ser Arg 
                165                 170                 175     


Val Asp Gly Ser Glu Tyr Pro Glu Leu Val Leu Glu Lys Ala Leu Asp 
            180                 185                 190         


Arg Glu Gln Arg Ala Thr His Leu Leu Val Leu Thr Ala Arg Asp Gly 
        195                 200                 205             


Gly Leu Pro Ala Arg Ser Gly Asp Ala Gln Val Thr Ile Ile Val Val 
    210                 215                 220                 


Asp Thr Asn Asp Asn Ala Pro Val Phe Glu Arg Ser Val Tyr Arg Thr 
225                 230                 235                 240 


Lys Val Pro Glu Thr Ala Pro Asn Gly Thr Val Leu Phe Arg Val Gln 
                245                 250                 255     


Ala Leu Asp Pro Asp Glu Gly Ser Asn Gly Glu Val Gln Tyr Ser Leu 
            260                 265                 270         


Ser Asn Ser Thr Gln Ala Glu Leu Arg His Arg Phe His Val His Pro 
        275                 280                 285             


Lys Ser Gly Glu Val Gln Val Ala Ala Ser Leu Gly Pro Pro Glu Thr 
    290                 295                 300                 


Leu Leu Glu Ala Tyr Ile Glu Ala Arg Asp Glu Gly Val Phe Gly Leu 
305                 310                 315                 320 


Ala Ser Thr Ala Lys Leu Leu Val Glu Val Thr Asp Val Asn Asp His 
                325                 330                 335     


Ala Pro Glu Leu Asp Phe Leu Thr Leu Ser Asn Pro Val Pro Glu Asp 
            340                 345                 350         


Ala Ala Pro Gly Thr Val Ile Ala Leu Phe Ser Val Lys Asp Glu Asp 
        355                 360                 365             


Leu Asp Ser Asn Gly Arg Val Ile Cys Gly Met Ser Ser Ala Gly Pro 
    370                 375                 380                 


Phe Gln Leu Thr Ala Ser Phe Asp Asn Tyr Tyr Ser Leu Leu Ile Asp 
385                 390                 395                 400 


Gly Pro Leu Asp Arg Glu Gln Ile Ser Glu Tyr Gln Val Leu Ile Thr 
                405                 410                 415     


Ala Ser Asp Ser Gly Ser Pro Pro Leu Ser Thr Arg Arg Thr Ile Thr 
            420                 425                 430         


Val Ser Val Ala Asp Val Asn Asp Asn Thr Pro Asn Phe Pro Gln Pro 
        435                 440                 445             


Gln Gln Glu Leu Phe Val Ala Glu Asn Asn Gly Pro Gly Ala Ser Leu 
    450                 455                 460                 


Gly Arg Val Phe Ala Gln Asp Pro Asp Leu Gly Lys Asn Gly Leu Val 
465                 470                 475                 480 


Ser Tyr Glu Leu Leu Asp Val Ile Ser Glu Gly Pro Ser Ala Ser Ser 
                485                 490                 495     


Leu Leu Ala Val Glu Ser Ser Ser Gly Ala Ile Thr Ala Lys Thr Ser 
            500                 505                 510         


Phe Asp Phe Glu Gln Leu Arg Gly Phe His Phe Gln Val Glu Gly Arg 
        515                 520                 525             


Asp Gly Gly Ile Pro Pro Arg Ser Ala Thr Val Thr Ile Asn Leu Phe 
    530                 535                 540                 


Val Val Asp Arg Asn Asp Asn Tyr Pro Val Ile Leu Phe Pro Leu Pro 
545                 550                 555                 560 


Arg Asn Gly Ser Val Pro Val Glu Ile Val Pro Arg Ser Ala Arg Thr 
                565                 570                 575     


Gly His Leu Val Thr Lys Val Val Ala Glu Asp Ala Asp Ser Gly Ser 
            580                 585                 590         


Asn Ala Trp Leu Ser Tyr His Ile Ser Arg Ala Ser Asp Ser Ser Leu 
        595                 600                 605             


Phe Arg Ile Ser Ala Asn Ile Gly Glu Leu Arg Thr Ala Arg Leu Val 
    610                 615                 620                 


Leu Pro Thr Asp Ala Val Lys Gln Arg Val Val Val Val Val Arg Asp 
625                 630                 635                 640 


His Gly Asp Pro Pro Leu Ser Ser Ser Val Thr Leu Gly Val Leu Leu 
                645                 650                 655     


Ser Asn Ser Val Pro Gln Leu Leu Pro Asp Phe Glu Asp Val Trp Glu 
            660                 665                 670         


Pro Gly Gly Gln Leu Ser Ala Gln Asn Leu Tyr Leu Val Ile Ala Leu 
        675                 680                 685             


Ala Cys Ile Ser Phe Leu Phe Leu Gly Cys Leu Leu Phe Phe Val Cys 
    690                 695                 700                 


Thr Lys Leu His Gln Ser Pro Gly Cys Cys Ala Gln Ser Cys Cys Arg 
705                 710                 715                 720 


Ser Thr Glu Asp Leu Arg Tyr Gly Ser Lys Met Val Ser Asn Pro Cys 
                725                 730                 735     


Met Thr Ser Ala Thr Ile Asp Val Thr Thr Val Glu Arg Leu Ser Gln 
            740                 745                 750         


Thr Tyr Leu Tyr Arg Ala Ser Leu Gly Leu Gly Ser Asp Asn Asn Ser 
        755                 760                 765             


Leu Leu Leu Arg Gly Glu Tyr Asn Ala Ala Asp Leu Arg Asn Leu Ala 
    770                 775                 780                 


Thr Gly Val Gly Leu Asn Leu Pro Ile Ser Cys Ile Gln Ile Arg Asn 
785                 790                 795                 800 


Arg Lys Gly Asp His Ala Asn Val Asn Ala Met Val Ser Lys Phe Tyr 
                805                 810                 815     


Gly Ile 
        

<210>  269
<211>  5684
<212>  DNA
<213>  Homo sapiens

<400>  269
gggttgagcg actcggaggc gagcggagga gctggaatat ggggagtcag cgaggacggt     60

ggggccagga gcccttggga gggcctacgg agggagcggc cccaggcgct ttctagagcg    120

tgagcggtgg gggagcaggc gcagggtggc acgagcggag gcggggcccg ggcgtggggc    180

acggctgggg aagctgccgc ctccggccct gcccggctgc ctccgccgcg gccagtggct    240

atggagcagg cgggcaccag acctgcggcg acagagcatc cacggctccg gcggcccatg    300

ccctggctgc tgctactgcc tctcctgctg ctgttgctgc tgctgctacc tggcccagcg    360

gcctcccagc tgcgatactc tgtgccagag gagcaggcac ccggcgcgct cgtgggcaac    420

gtggctcgcg cgctggggct tgagctgcgg cgcttggggc cgggttgctt gcgcatcaac    480

catctgggtg cgcccagtcc gcgctacctg gagctggacc tgacgagtgg agcgctcttc    540

gtcaacgagc gcattgatcg ggaggcgctg tgtgagcagc ggcctcgctg cctgctcagc    600

ctggaagtgc tggcgcacaa ccccgtggcg gtgagcgccg ttgaggtgga aatattggac    660

atcaacgaca actcaccgcg tttcccgcgg cccaactacc agcttcaggt aagcgaatcg    720

gtggcgcctg gagcgcgctt tcacatagag agtgcgcagg accccgacgt gggcgccaac    780

tcagtacaga cctacgagct cagccccagc gagcacttcg agctggacct taagcccctg    840

caggagaaca gtaaagtgct tgagctggtg ctgcgtaagg gcctagaccg ggagcaggca    900

gccttgcacc acctggttct cacagccgtg gatgggggca ttccagcccg ctcgggtacg    960

gcacagatct ctgtgcgtgt cctggacact aacgacaact ctcctgcctt tgaccagtcc   1020

acttatcgcg tccagctacg ggaggactca cccccaggca cattggtggt gaagctgaat   1080

gcctcagacc cggatgaggg ctccaatggt gagctcaggt actccttgag cagctacacg   1140

tcggaccggg agaggcagct cttcagcata gatgccagta ccggggaagt gcgagtaatt   1200

ggggggctgg attatgagga agcctcctcc taccagatct atgtgcaggc gactgaccgg   1260

ggtccagtgc ccatggcagg tcactgcaag gtgctggtgg acatcgtgga cgtgaatgac   1320

aatgccccag aggtggtgct cacggacctg tatagcccag tgcctgagaa tgctacaccc   1380

aacaccattg tggccgttct cagtgtcaat gaccaagact caggccccaa ccggaaagtg   1440

agcctgggtc tggaggccac actgcctttc cgactgaatg gctttggaaa ctcctataca   1500

ctggtggtga gcggcccact ggaccgagag cgggtggctg tctacaacat cacggtgaca   1560

gccacagatg ggggaatacc gcagctcaca tccctgcgta cactgaaggt tgagatctct   1620

gacatcaatg acaatccacc aagcttcctg gaggactcct attccatcta catacaggag   1680

aacaatttgc caggtgtgtt gctctgtact gtgcaagcca cagacccaga tgaaaaggag   1740

aatgcagagg tgacctactc ccttctggag agggagattc aagggctgcc agtcacctcc   1800

tatgtctcca ttaacagtgc cagtggcagc ctttatgctg tcaactcctt tgactatgag   1860

aagtttcggg agttctttgt gactgtggag gctcaggaca aggggagccc accactgagc   1920

agcactgtga ctgccaacgt atatgtggtg gacatgaatg accatgcccc tcacattctg   1980

taccctacct caaccaactc gtcagcagcc ttcgagatgg tgcctcgaac tgcccctgct   2040

ggctacctgg tcaccaaagt catagctatg gactcagact ctgggcaaaa tgcttggctt   2100

ttttaccatc tagcccagac ttctgacctg gacctcttta aggtagagct gcacacagga   2160

gaaattagga ctaccaggaa gatgggagat gagagtggta gcactttcaa cctgaccgtg   2220

gtggtccgag ataatggaga gccatcacta tcagcctctg tggccattac agtagctgtg   2280

gtggataggg tttccaaaat cctccctgac actcagaggc atgttaagag ccctcggaca   2340

tactctgaaa ttacccttta tctaataata gcattaagca cagtgtcttt tatatttctt   2400

ttgacaatca tcattttgag catcatcaag tgctaccgct acactgcgta tggcactgca   2460

tgctgtggag gcttctgtgg agtaagggaa aggtcccctg cagaactgta caaacaagcc   2520

aacaacaata ttgatgccag gataccgcat ggcctcaaag tgcagcctca cttcattgaa   2580

gttcgaggga atggctccct caccaagacc tactgctaca aggcctgtct gacagcaggc   2640

tcagggagtg acactttcat gttttacaat acaggggccc agacaggacc agggccttcg   2700

ggagcccaag cagcagtgac tgacagcagg aatctcacag gccaaagtgg tcagaatgct   2760

gggaacctga ttattctcaa aaatgaggct gtttctcaaa atgagccacg acagcccaac   2820

cctgactggc gttactctgc ctccctgaga gcaggcatgc acagctctgt gcacctagag   2880

gaggctggca ttctacgggc tggtccagga gggcctgatc agcagtggcc aacagtatcc   2940

agtgcaacac cagaaccaga ggcaggagaa gtgtcccctc cagtcggtgc gggtgtcaac   3000

agcaacagct ggacctttaa atacggacca ggcaacccca aacaatccgg tcccggtgag   3060

ttgcccgaca aattcattat cccaggatct cctgcaatca tctccatccg gcaggagcct   3120

actaacagcc aaattgacaa aagtgacttc ataaccttcg gcaaaaagga ggagaccaag   3180

aaaaagaaga aaaagaagaa gggtaacaag acccaggaga aaaaagagaa agggaacagc   3240

acgactgaca acagtgacca gtgaggtcct caaatggaaa caagccactt agccagtttt   3300

tgtaataatg gcaaatctct cccatgtagc aattccctgc tcctttttcc tatctacatg   3360

agccctctta gagacctcag aaatctgcag aaagttccct gtgtctgtct agaacgcatt   3420

taacaggttt tgtcgtaaaa gctttactaa gtctggtgtt aactctttct ctccactctg   3480

gcttgttttc agaacctaaa aagcagaccc aagtttcctt tctcctccgc cgcaaaggag   3540

aggcttccca gccccgccag tgagaggttg gactctctgc cctgtgctcc ggggatcctg   3600

tcttgatgac acttgcaggg caggctgaaa agttttgaga ttgagcagct tgggagtttg   3660

tggccactgg gtatgtgtgg ctaccgcggg tatgcgagtg ccagatattg gctgagacga   3720

gccagcttag actaattggt acaaggaagg caagaaaaca aagacaaata aacagcggaa   3780

gttatcagta tggaggggaa gtgtaaactt aaagggacca gactttctaa atcttacaac   3840

tcaagaggtg gcagccaccc tctaggagac aaaactaccc ccactgacaa ggctttagga   3900

gaccctaaag tctgttggct gtgacgtcat tatacctaaa atctgcatca tacctgcaag   3960

ccaacagttc agtgttttaa cagagaacca ccctgggaaa cagaagcaga tctgatgtgt   4020

ttcctataca tgtcctgtgc tcactttatt aaaaattctt ttgcacacaa tgtttatgaa   4080

aaggccagat ccttttccaa tacttatgca aaagcaaaag aaaaccccga cacctcacct   4140

ttcgctgttt gttgtttcat agatttattt aaaaaaagag aaagtctata gctataaatc   4200

tttaaagaga aatatgaata caattcccct aaactctcct caaaagagaa ttcagtctac   4260

agccatttaa atgatcattg ctgctacaga agtgctttaa gagaattgcc tgaaacatct   4320

gtattatatc ggccacctgc caatcacagc tttactcttt caggtcactc tggggctgcc   4380

tcttgcatgt attactaaat aaaatgatct ctctttctct ctctctctct cttttctaag   4440

aaacaattat gtgcactttg atacacaacc ttctctaacc aactatatat caagacccaa   4500

aaattgaaga aaaatattgt tttctcatac agtgagcaga tttttcaatc tactaattct   4560

gtgacttgtc ttggtgtgct agcctacacc ttctctttgg tttagttttc cttttctata   4620

acactctgaa ttgctaatct tactaacacc tatgatgtta cctgaaatca atctcccata   4680

tgtatgctgt atgctatgct aagactcctg aaatatactt actctgtgct tgtgtatgtg   4740

aatgttaatg caactattac ctagagtgaa ctttaagctt tattgttgaa tgtaattcca   4800

ttatatttcc ttttgtacac ctgtgaaaaa gtggagtagt gtttttttaa ccattgttaa   4860

tcagcttttg tgtatgaaag acacagtaaa atttctttct taaatcaaga tactggtgat   4920

tcaaggaatt ttatttatgg tccagccaag agccatctcg tgccaagact tctgctggca   4980

agggaatgga taaagctgtt ttgttctagt aacaattttg gaatgaatac tgacaatatt   5040

ccatgagggt gtgcaagcac aaattttacc aatctgacct ctttgaagtt gcagaatgct   5100

ttgaaattct aatggtatct gaaatatcag ctcatagaaa gtaacaaaat ttgctgtcac   5160

cttaaataag acattttaat tttgttataa tgtacaattt agaagtttga ttaattatat   5220

tatctattta ggcattaata taaaagaggt aggagtctgt tatttaaaaa aagcattaaa   5280

tttaaaaaaa aactgtcttg tctactttta gcttcattct cccatatttt gaagggtgtg   5340

taacttcagc tctgcaggat tgcatggggt aaaacttgtt accaacacat gtgaaccatt   5400

gctacattgt aggttgtgat cattttgccc cactgaagcc catgtatctg accttacgtg   5460

ccttttgaac taggagaatc gggctaattt attaatgatg ataattataa tgtatctgta   5520

cagcactttt tacatttgcg aagtgctttc caatccatgt tagttactag ttattacagc   5580

tgtaaggata aaacacgtca tgtggattca ttttgaattg gtgctattgg tatttcctct   5640

gttattgcta ataaatgaaa atggtggtat gaaaaaaaaa aaaa                    5684


<210>  270
<211>  1007
<212>  PRT
<213>  Homo sapiens

<400>  270


Met Glu Gln Ala Gly Thr Arg Pro Ala Ala Thr Glu His Pro Arg Leu 
1               5                   10                  15      


Arg Arg Pro Met Pro Trp Leu Leu Leu Leu Pro Leu Leu Leu Leu Leu 
            20                  25                  30          


Leu Leu Leu Leu Pro Gly Pro Ala Ala Ser Gln Leu Arg Tyr Ser Val 
        35                  40                  45              


Pro Glu Glu Gln Ala Pro Gly Ala Leu Val Gly Asn Val Ala Arg Ala 
    50                  55                  60                  


Leu Gly Leu Glu Leu Arg Arg Leu Gly Pro Gly Cys Leu Arg Ile Asn 
65                  70                  75                  80  


His Leu Gly Ala Pro Ser Pro Arg Tyr Leu Glu Leu Asp Leu Thr Ser 
                85                  90                  95      


Gly Ala Leu Phe Val Asn Glu Arg Ile Asp Arg Glu Ala Leu Cys Glu 
            100                 105                 110         


Gln Arg Pro Arg Cys Leu Leu Ser Leu Glu Val Leu Ala His Asn Pro 
        115                 120                 125             


Val Ala Val Ser Ala Val Glu Val Glu Ile Leu Asp Ile Asn Asp Asn 
    130                 135                 140                 


Ser Pro Arg Phe Pro Arg Pro Asn Tyr Gln Leu Gln Val Ser Glu Ser 
145                 150                 155                 160 


Val Ala Pro Gly Ala Arg Phe His Ile Glu Ser Ala Gln Asp Pro Asp 
                165                 170                 175     


Val Gly Ala Asn Ser Val Gln Thr Tyr Glu Leu Ser Pro Ser Glu His 
            180                 185                 190         


Phe Glu Leu Asp Leu Lys Pro Leu Gln Glu Asn Ser Lys Val Leu Glu 
        195                 200                 205             


Leu Val Leu Arg Lys Gly Leu Asp Arg Glu Gln Ala Ala Leu His His 
    210                 215                 220                 


Leu Val Leu Thr Ala Val Asp Gly Gly Ile Pro Ala Arg Ser Gly Thr 
225                 230                 235                 240 


Ala Gln Ile Ser Val Arg Val Leu Asp Thr Asn Asp Asn Ser Pro Ala 
                245                 250                 255     


Phe Asp Gln Ser Thr Tyr Arg Val Gln Leu Arg Glu Asp Ser Pro Pro 
            260                 265                 270         


Gly Thr Leu Val Val Lys Leu Asn Ala Ser Asp Pro Asp Glu Gly Ser 
        275                 280                 285             


Asn Gly Glu Leu Arg Tyr Ser Leu Ser Ser Tyr Thr Ser Asp Arg Glu 
    290                 295                 300                 


Arg Gln Leu Phe Ser Ile Asp Ala Ser Thr Gly Glu Val Arg Val Ile 
305                 310                 315                 320 


Gly Gly Leu Asp Tyr Glu Glu Ala Ser Ser Tyr Gln Ile Tyr Val Gln 
                325                 330                 335     


Ala Thr Asp Arg Gly Pro Val Pro Met Ala Gly His Cys Lys Val Leu 
            340                 345                 350         


Val Asp Ile Val Asp Val Asn Asp Asn Ala Pro Glu Val Val Leu Thr 
        355                 360                 365             


Asp Leu Tyr Ser Pro Val Pro Glu Asn Ala Thr Pro Asn Thr Ile Val 
    370                 375                 380                 


Ala Val Leu Ser Val Asn Asp Gln Asp Ser Gly Pro Asn Arg Lys Val 
385                 390                 395                 400 


Ser Leu Gly Leu Glu Ala Thr Leu Pro Phe Arg Leu Asn Gly Phe Gly 
                405                 410                 415     


Asn Ser Tyr Thr Leu Val Val Ser Gly Pro Leu Asp Arg Glu Arg Val 
            420                 425                 430         


Ala Val Tyr Asn Ile Thr Val Thr Ala Thr Asp Gly Gly Ile Pro Gln 
        435                 440                 445             


Leu Thr Ser Leu Arg Thr Leu Lys Val Glu Ile Ser Asp Ile Asn Asp 
    450                 455                 460                 


Asn Pro Pro Ser Phe Leu Glu Asp Ser Tyr Ser Ile Tyr Ile Gln Glu 
465                 470                 475                 480 


Asn Asn Leu Pro Gly Val Leu Leu Cys Thr Val Gln Ala Thr Asp Pro 
                485                 490                 495     


Asp Glu Lys Glu Asn Ala Glu Val Thr Tyr Ser Leu Leu Glu Arg Glu 
            500                 505                 510         


Ile Gln Gly Leu Pro Val Thr Ser Tyr Val Ser Ile Asn Ser Ala Ser 
        515                 520                 525             


Gly Ser Leu Tyr Ala Val Asn Ser Phe Asp Tyr Glu Lys Phe Arg Glu 
    530                 535                 540                 


Phe Phe Val Thr Val Glu Ala Gln Asp Lys Gly Ser Pro Pro Leu Ser 
545                 550                 555                 560 


Ser Thr Val Thr Ala Asn Val Tyr Val Val Asp Met Asn Asp His Ala 
                565                 570                 575     


Pro His Ile Leu Tyr Pro Thr Ser Thr Asn Ser Ser Ala Ala Phe Glu 
            580                 585                 590         


Met Val Pro Arg Thr Ala Pro Ala Gly Tyr Leu Val Thr Lys Val Ile 
        595                 600                 605             


Ala Met Asp Ser Asp Ser Gly Gln Asn Ala Trp Leu Phe Tyr His Leu 
    610                 615                 620                 


Ala Gln Thr Ser Asp Leu Asp Leu Phe Lys Val Glu Leu His Thr Gly 
625                 630                 635                 640 


Glu Ile Arg Thr Thr Arg Lys Met Gly Asp Glu Ser Gly Ser Thr Phe 
                645                 650                 655     


Asn Leu Thr Val Val Val Arg Asp Asn Gly Glu Pro Ser Leu Ser Ala 
            660                 665                 670         


Ser Val Ala Ile Thr Val Ala Val Val Asp Arg Val Ser Lys Ile Leu 
        675                 680                 685             


Pro Asp Thr Gln Arg His Val Lys Ser Pro Arg Thr Tyr Ser Glu Ile 
    690                 695                 700                 


Thr Leu Tyr Leu Ile Ile Ala Leu Ser Thr Val Ser Phe Ile Phe Leu 
705                 710                 715                 720 


Leu Thr Ile Ile Ile Leu Ser Ile Ile Lys Cys Tyr Arg Tyr Thr Ala 
                725                 730                 735     


Tyr Gly Thr Ala Cys Cys Gly Gly Phe Cys Gly Val Arg Glu Arg Ser 
            740                 745                 750         


Pro Ala Glu Leu Tyr Lys Gln Ala Asn Asn Asn Ile Asp Ala Arg Ile 
        755                 760                 765             


Pro His Gly Leu Lys Val Gln Pro His Phe Ile Glu Val Arg Gly Asn 
    770                 775                 780                 


Gly Ser Leu Thr Lys Thr Tyr Cys Tyr Lys Ala Cys Leu Thr Ala Gly 
785                 790                 795                 800 


Ser Gly Ser Asp Thr Phe Met Phe Tyr Asn Thr Gly Ala Gln Thr Gly 
                805                 810                 815     


Pro Gly Pro Ser Gly Ala Gln Ala Ala Val Thr Asp Ser Arg Asn Leu 
            820                 825                 830         


Thr Gly Gln Ser Gly Gln Asn Ala Gly Asn Leu Ile Ile Leu Lys Asn 
        835                 840                 845             


Glu Ala Val Ser Gln Asn Glu Pro Arg Gln Pro Asn Pro Asp Trp Arg 
    850                 855                 860                 


Tyr Ser Ala Ser Leu Arg Ala Gly Met His Ser Ser Val His Leu Glu 
865                 870                 875                 880 


Glu Ala Gly Ile Leu Arg Ala Gly Pro Gly Gly Pro Asp Gln Gln Trp 
                885                 890                 895     


Pro Thr Val Ser Ser Ala Thr Pro Glu Pro Glu Ala Gly Glu Val Ser 
            900                 905                 910         


Pro Pro Val Gly Ala Gly Val Asn Ser Asn Ser Trp Thr Phe Lys Tyr 
        915                 920                 925             


Gly Pro Gly Asn Pro Lys Gln Ser Gly Pro Gly Glu Leu Pro Asp Lys 
    930                 935                 940                 


Phe Ile Ile Pro Gly Ser Pro Ala Ile Ile Ser Ile Arg Gln Glu Pro 
945                 950                 955                 960 


Thr Asn Ser Gln Ile Asp Lys Ser Asp Phe Ile Thr Phe Gly Lys Lys 
                965                 970                 975     


Glu Glu Thr Lys Lys Lys Lys Lys Lys Lys Lys Gly Asn Lys Thr Gln 
            980                 985                 990         


Glu Lys Lys Glu Lys Gly Asn Ser  Thr Thr Asp Asn Ser  Asp Gln 
        995                 1000                 1005         

<210>  271
<211>  2655
<212>  DNA
<213>  Homo sapiens

<400>  271
atggagcagg cgggcaccag acctgcggcg acagagcatc cacggctccg gcggcccatg     60

ccctggctgc tgctactgcc tctcctgctg ctgttgctgc tgctgctacc tggccctgcg    120

gcctcccagc tgcgatactc tgtgccagag gagcaggcac ccggcgcgct cgtgggcaac    180

gtggctcgcg cgctggggct tgagctgcgg cgcttggggc cgggttgctt gcgcatcaac    240

catctgggtg cgcccagtcc gcgctacctg gagctggacc tgacgagtgg agcgctcttc    300

gtcaacgagc gcattgatcg ggaggcgctg tgtgagcagc ggcctcgctg cctgctcagc    360

ttggaagtgc tggcgcacaa ccccgtggcg gtgagcgccg ttgaggtgga aatattggac    420

atcaacgaca actcaccgcg tttcccgcgg cccaactacc agcttcaggt aagcgaatcg    480

gtggcgcctg gagcgcgctt tcacatagag agtgcgcagg accccgacgt gggcgccaac    540

tcagtacaga cctacgagct cagccccagc gagcacttcg agctggacct taagcccctg    600

caggagaaca gtaaagtgct tgagctggtg ctgcgtaagg gcctagaccg ggagcaggca    660

gccttgcacc acctggttct cacagccgtg gatgggggca tcccagcccg ctcgggtacg    720

gcacagatct ctgtgcgtgt cctggacact aacgacaact ctcctgcctt tgaccagtcc    780

acttatcgcg tccagctacg ggaggactca cccccaggca cattggtggt gaagctgaat    840

gcctcagacc cggatgaggg ctccaatggt gagctcaggt actccttgag cagctacacg    900

tcggaccggg agaggcagct cttcagcata gatgccagta ccggggaagt gcgagtaatt    960

ggggggctgg attatgagga agcctcctcc taccagatct atgtgcaggc gactgaccgg   1020

ggtccagtgc ccatggcagg tcactgcaag gtgctggtgg acatcgtgga cgtgaatgac   1080

aatgccccag aggtggtgct cacggacctg tatagcccag tgcctgagaa tgctacaccc   1140

aacaccattg tggccgttct cagtgtcaat gaccaagact caggccccaa ccggaaagtg   1200

agcctgggtc tggaggccac actgcctttc cgactgaatg gctttggaaa ctcctataca   1260

ctggtggtga gcggcccact ggaccgagag cgggtggctg tctacaacat cacggtgaca   1320

gccacagatg ggggaatacc gcagctcaca tccctgcgta cactgaaggt tgagatctct   1380

gacatcaatg acaatccacc aagcttcctg gaggactcct attccatcta catacaggag   1440

aacaatttgc caggtgtgtt gctctgtact gtgcaagcca cagacccaga tgaaaaggag   1500

aatgcagagg tgacctactc ccttctggag agggagattc aagggctgcc agtcacctcc   1560

tatgtctcca ttaacagtgc cagtggcagc ctttatgctg tcaactcctt tgactatgag   1620

aagtttcggg agttctttgt gactgtggag gctcaggaca aggggagccc accactgagc   1680

agcactgtga ctgccaacgt atatgtggtg gacatgaatg accatgcccc tcacattctg   1740

taccctacct caaccaactc gtcagcagcc ttcgagatgg tgcctcgaac tgcccctgct   1800

ggctacctgg tcaccaaagt catagctatg gactcagact ctgggcaaaa tgcttggctt   1860

ttttaccatc tagcccagac ttctgacctg gacctcttta aggtagagct gcacacagga   1920

gaaattagga ctaccaggaa gatgggagat gagagtggta gcactttcaa cctgaccgtg   1980

gtggtccgag ataatggaga gccatcacta tcagcctctg tggccattac agtagctgtg   2040

gtggataggg tttccaaaat cctccctgac actcagaggc atgttaagag ccctcggaca   2100

tactctgaaa ttacccttta tctaataata gcattaagca cagtgtcttt tatatttctt   2160

ttgacaatca tcattttgag catcatcaag tgctaccgct acactgcgta tggcactgca   2220

tgctgtggag gcttctgtgg agtaagggaa aggtcccctg cagaactgta caaacaagcc   2280

aacaacaata ttgatgccag gataccgcat ggcctcaaag tgcagcctca cttcattgaa   2340

gttcgaggga atggctccct caccaagacc tactgctaca aggcctgtct gacagcaggc   2400

tcagggagtg acactttcat gttttacaat acaggggccc agacaggacc agggccttcg   2460

ggagcccaag cagcagtgac tgacagcagg aatctcacag gccaaagtgg tcagaatgct   2520

gggaacctga ttattctcaa aaatgaggct gtttctcaaa atgaggtgag acagtggtca   2580

gggggtcttc tacaaactca tgcatttgtt acacatcccc caatatcctg tgatttggct   2640

ttattgagtc attaa                                                    2655


<210>  272
<211>  884
<212>  PRT
<213>  Homo sapiens

<400>  272


Met Glu Gln Ala Gly Thr Arg Pro Ala Ala Thr Glu His Pro Arg Leu 
1               5                   10                  15      


Arg Arg Pro Met Pro Trp Leu Leu Leu Leu Pro Leu Leu Leu Leu Leu 
            20                  25                  30          


Leu Leu Leu Leu Pro Gly Pro Ala Ala Ser Gln Leu Arg Tyr Ser Val 
        35                  40                  45              


Pro Glu Glu Gln Ala Pro Gly Ala Leu Val Gly Asn Val Ala Arg Ala 
    50                  55                  60                  


Leu Gly Leu Glu Leu Arg Arg Leu Gly Pro Gly Cys Leu Arg Ile Asn 
65                  70                  75                  80  


His Leu Gly Ala Pro Ser Pro Arg Tyr Leu Glu Leu Asp Leu Thr Ser 
                85                  90                  95      


Gly Ala Leu Phe Val Asn Glu Arg Ile Asp Arg Glu Ala Leu Cys Glu 
            100                 105                 110         


Gln Arg Pro Arg Cys Leu Leu Ser Leu Glu Val Leu Ala His Asn Pro 
        115                 120                 125             


Val Ala Val Ser Ala Val Glu Val Glu Ile Leu Asp Ile Asn Asp Asn 
    130                 135                 140                 


Ser Pro Arg Phe Pro Arg Pro Asn Tyr Gln Leu Gln Val Ser Glu Ser 
145                 150                 155                 160 


Val Ala Pro Gly Ala Arg Phe His Ile Glu Ser Ala Gln Asp Pro Asp 
                165                 170                 175     


Val Gly Ala Asn Ser Val Gln Thr Tyr Glu Leu Ser Pro Ser Glu His 
            180                 185                 190         


Phe Glu Leu Asp Leu Lys Pro Leu Gln Glu Asn Ser Lys Val Leu Glu 
        195                 200                 205             


Leu Val Leu Arg Lys Gly Leu Asp Arg Glu Gln Ala Ala Leu His His 
    210                 215                 220                 


Leu Val Leu Thr Ala Val Asp Gly Gly Ile Pro Ala Arg Ser Gly Thr 
225                 230                 235                 240 


Ala Gln Ile Ser Val Arg Val Leu Asp Thr Asn Asp Asn Ser Pro Ala 
                245                 250                 255     


Phe Asp Gln Ser Thr Tyr Arg Val Gln Leu Arg Glu Asp Ser Pro Pro 
            260                 265                 270         


Gly Thr Leu Val Val Lys Leu Asn Ala Ser Asp Pro Asp Glu Gly Ser 
        275                 280                 285             


Asn Gly Glu Leu Arg Tyr Ser Leu Ser Ser Tyr Thr Ser Asp Arg Glu 
    290                 295                 300                 


Arg Gln Leu Phe Ser Ile Asp Ala Ser Thr Gly Glu Val Arg Val Ile 
305                 310                 315                 320 


Gly Gly Leu Asp Tyr Glu Glu Ala Ser Ser Tyr Gln Ile Tyr Val Gln 
                325                 330                 335     


Ala Thr Asp Arg Gly Pro Val Pro Met Ala Gly His Cys Lys Val Leu 
            340                 345                 350         


Val Asp Ile Val Asp Val Asn Asp Asn Ala Pro Glu Val Val Leu Thr 
        355                 360                 365             


Asp Leu Tyr Ser Pro Val Pro Glu Asn Ala Thr Pro Asn Thr Ile Val 
    370                 375                 380                 


Ala Val Leu Ser Val Asn Asp Gln Asp Ser Gly Pro Asn Arg Lys Val 
385                 390                 395                 400 


Ser Leu Gly Leu Glu Ala Thr Leu Pro Phe Arg Leu Asn Gly Phe Gly 
                405                 410                 415     


Asn Ser Tyr Thr Leu Val Val Ser Gly Pro Leu Asp Arg Glu Arg Val 
            420                 425                 430         


Ala Val Tyr Asn Ile Thr Val Thr Ala Thr Asp Gly Gly Ile Pro Gln 
        435                 440                 445             


Leu Thr Ser Leu Arg Thr Leu Lys Val Glu Ile Ser Asp Ile Asn Asp 
    450                 455                 460                 


Asn Pro Pro Ser Phe Leu Glu Asp Ser Tyr Ser Ile Tyr Ile Gln Glu 
465                 470                 475                 480 


Asn Asn Leu Pro Gly Val Leu Leu Cys Thr Val Gln Ala Thr Asp Pro 
                485                 490                 495     


Asp Glu Lys Glu Asn Ala Glu Val Thr Tyr Ser Leu Leu Glu Arg Glu 
            500                 505                 510         


Ile Gln Gly Leu Pro Val Thr Ser Tyr Val Ser Ile Asn Ser Ala Ser 
        515                 520                 525             


Gly Ser Leu Tyr Ala Val Asn Ser Phe Asp Tyr Glu Lys Phe Arg Glu 
    530                 535                 540                 


Phe Phe Val Thr Val Glu Ala Gln Asp Lys Gly Ser Pro Pro Leu Ser 
545                 550                 555                 560 


Ser Thr Val Thr Ala Asn Val Tyr Val Val Asp Met Asn Asp His Ala 
                565                 570                 575     


Pro His Ile Leu Tyr Pro Thr Ser Thr Asn Ser Ser Ala Ala Phe Glu 
            580                 585                 590         


Met Val Pro Arg Thr Ala Pro Ala Gly Tyr Leu Val Thr Lys Val Ile 
        595                 600                 605             


Ala Met Asp Ser Asp Ser Gly Gln Asn Ala Trp Leu Phe Tyr His Leu 
    610                 615                 620                 


Ala Gln Thr Ser Asp Leu Asp Leu Phe Lys Val Glu Leu His Thr Gly 
625                 630                 635                 640 


Glu Ile Arg Thr Thr Arg Lys Met Gly Asp Glu Ser Gly Ser Thr Phe 
                645                 650                 655     


Asn Leu Thr Val Val Val Arg Asp Asn Gly Glu Pro Ser Leu Ser Ala 
            660                 665                 670         


Ser Val Ala Ile Thr Val Ala Val Val Asp Arg Val Ser Lys Ile Leu 
        675                 680                 685             


Pro Asp Thr Gln Arg His Val Lys Ser Pro Arg Thr Tyr Ser Glu Ile 
    690                 695                 700                 


Thr Leu Tyr Leu Ile Ile Ala Leu Ser Thr Val Ser Phe Ile Phe Leu 
705                 710                 715                 720 


Leu Thr Ile Ile Ile Leu Ser Ile Ile Lys Cys Tyr Arg Tyr Thr Ala 
                725                 730                 735     


Tyr Gly Thr Ala Cys Cys Gly Gly Phe Cys Gly Val Arg Glu Arg Ser 
            740                 745                 750         


Pro Ala Glu Leu Tyr Lys Gln Ala Asn Asn Asn Ile Asp Ala Arg Ile 
        755                 760                 765             


Pro His Gly Leu Lys Val Gln Pro His Phe Ile Glu Val Arg Gly Asn 
    770                 775                 780                 


Gly Ser Leu Thr Lys Thr Tyr Cys Tyr Lys Ala Cys Leu Thr Ala Gly 
785                 790                 795                 800 


Ser Gly Ser Asp Thr Phe Met Phe Tyr Asn Thr Gly Ala Gln Thr Gly 
                805                 810                 815     


Pro Gly Pro Ser Gly Ala Gln Ala Ala Val Thr Asp Ser Arg Asn Leu 
            820                 825                 830         


Thr Gly Gln Ser Gly Gln Asn Ala Gly Asn Leu Ile Ile Leu Lys Asn 
        835                 840                 845             


Glu Ala Val Ser Gln Asn Glu Val Arg Gln Trp Ser Gly Gly Leu Leu 
    850                 855                 860                 


Gln Thr His Ala Phe Val Thr His Pro Pro Ile Ser Cys Asp Leu Ala 
865                 870                 875                 880 


Leu Leu Ser His 
                

<210>  273
<211>  2534
<212>  DNA
<213>  Homo sapiens

<400>  273
agtaacctgt tgcagaaaag tgaaagtata tccgcaacag ttggctctga ttgcagagag     60

cgcgcttgtg agaactgatg gcgggtacgc gcagaaaatc tttgcaaaac aggcaagtgg    120

gatctcttct catttttctg tgcatatctg tgggggatgc gacaactatc cgctattcag    180

tggcagagga aatggagagc ggctcgtttg tggccaacgt agctaaggac ctaggactgg    240

aggtagggaa gctggctgcg cgcggggcgc ggctggtttc cgagggcaac aaaatgcatt    300

tccggctcca ccgcaagacg ggagatttgt ttgtgaagga gaaactggat cgggagtcac    360

tttgtggcaa agccgaccct tgtgttctgc actttgaagt agtcctggtg gagccgctgc    420

agtccttccg ggccgaggtc agggtatttg atatcaatga caatgcccca gttttcctaa    480

acaaggagcc gcttttaaag attccggaga gcaccccttt gggttcacgt tttcctctgc    540

agagcgccca ggatctggac gtgggcctta acggtctcca gaactacacc ctgagtgcca    600

atgggtattt ccacctgcac acccgcttct gcagccacgg gcctaaatat gctgagctgg    660

tgctgaacaa acccctggac cgagaggagc agcctgaagt caacttgaca attacggcgg    720

tggacggcgg gtccccgcct aagtctggca cagctcacat ccacgtggtg gttctggatg    780

tcaacgacca cgtgccccag ttctcgcgac tggtgtacag agcccaggta tcagagaaca    840

gccccaatgg ctctttggtg gccacggtga ctgccgtgga cctagacgag ggcaccaaca    900

aagcgataac ttactcttta gctcaaaacc cagaagcaat tctcaagacg tttcagattg    960

accctcaaaa tggagaagtt cgactaagag gacccctcga ttttgaagcc attgaaacat   1020

acgacattga cattcaagct acagatggtg gaggcctctc tgcccacagc aaagtcctgg   1080

tagaagtggt ggatgtgaat gacaatcctc ccgaagtgat ggtctcctct gtgtccagcc   1140

cactccctga agactcacca ccacagacag tagtagccct tttcactatc agagaccggg   1200

acattcgagt gggaggaaaa gtcacctgct tcctcagaga agaccttccc tttgtaatca   1260

aacctacatt tgggaattct tactcactgg tcactgacag aagcttggat cgggaggagg   1320

tctcaggcta taatatcacc attgttgcca tggatactgg accacctagc ttgtctgccg   1380

agactatgat agaggtgcta atatccgacg ttaatgacaa tcctccaata tttcgggaag   1440

attcctatat cttgactgtt cgagaaaaca acagtcctgc ggtttttatt ggcaaagtcc   1500

atgctgagga tcttgatttg ggtgagaatg cccaaataac atattctctg ttgcctccaa   1560

aaaacggaga tctttcagtc tttgcttaca tatccataaa ttcaggcaat gggaagctct   1620

acgcgctgag aaccatggat tatgaggcca ttcaagattt tcaatttgtg gtaaaggcaa   1680

ctgatggggg cttcctgtca ctgagtagcc aagttactgt cagagtggtt gtcctagatg   1740

acaatgacaa tcgtccaatg atcttatacc cactgcagaa cggcaccttg ccctgcaatg   1800

acctggtgcc caggtctgca gaggcaggct acctagtgac caaagtggtg gctgtggatg   1860

gtgactcagg tcagaattct tggctttcat atcatctact taaggccact gaccttgggt   1920

tattttctgt tcaaagacaa aatggagaaa tccatacatt aaggcagata tctgagagag   1980

accccatgat gcagaaattg atcattcttg ttcaggatca cggccaacca gctctttcca   2040

ctactgtctc actcaacatc ctgctggtag atggcttttc agagccctac ctgcagttcc   2100

aggatccaac caagcattct agaaaggtaa atccatccac taaatatttg gtcatttctc   2160

tggtcatcct ttcctttctc tttctcctct ctgtcatagt gatcttcatt atacatgtct   2220

accaaaagat taaatataga gaaaagttca caattcaaga gcatttctat gatgactgta   2280

atttctctaa caacctggta caaggacaag gcaatggatc cttatctcgg ccttgtccat   2340

atgaaatgtg ttcagccact ggcactggta atagtgagtt tcgctttctt aagcgtttta   2400

tgcccaactt ccctttccct catgccactg gggagataaa aatggaggct ggctccagtt   2460

tgcccccaaa ttctgatagg aataagtctc agagattaga gggccatgac caggtatctg   2520

atgactatat gtag                                                     2534


<210>  274
<211>  818
<212>  PRT
<213>  Homo sapiens

<400>  274


Met Ala Gly Thr Arg Arg Lys Ser Leu Gln Asn Arg Gln Val Gly Ser 
1               5                   10                  15      


Leu Leu Ile Phe Leu Cys Ile Ser Val Gly Asp Ala Thr Thr Ile Arg 
            20                  25                  30          


Tyr Ser Val Ala Glu Glu Met Glu Ser Gly Ser Phe Val Ala Asn Val 
        35                  40                  45              


Ala Lys Asp Leu Gly Leu Glu Val Gly Lys Leu Ala Ala Arg Gly Ala 
    50                  55                  60                  


Arg Leu Val Ser Glu Gly Asn Lys Met His Phe Arg Leu His Arg Lys 
65                  70                  75                  80  


Thr Gly Asp Leu Phe Val Lys Glu Lys Leu Asp Arg Glu Ser Leu Cys 
                85                  90                  95      


Gly Lys Ala Asp Pro Cys Val Leu His Phe Glu Val Val Leu Val Glu 
            100                 105                 110         


Pro Leu Gln Ser Phe Arg Ala Glu Val Arg Val Phe Asp Ile Asn Asp 
        115                 120                 125             


Asn Ala Pro Val Phe Leu Asn Lys Glu Pro Leu Leu Lys Ile Pro Glu 
    130                 135                 140                 


Ser Thr Pro Leu Gly Ser Arg Phe Pro Leu Gln Ser Ala Gln Asp Leu 
145                 150                 155                 160 


Asp Val Gly Leu Asn Gly Leu Gln Asn Tyr Thr Leu Ser Ala Asn Gly 
                165                 170                 175     


Tyr Phe His Leu His Thr Arg Phe Cys Ser His Gly Pro Lys Tyr Ala 
            180                 185                 190         


Glu Leu Val Leu Asn Lys Pro Leu Asp Arg Glu Glu Gln Pro Glu Val 
        195                 200                 205             


Asn Leu Thr Ile Thr Ala Val Asp Gly Gly Ser Pro Pro Lys Ser Gly 
    210                 215                 220                 


Thr Ala His Ile His Val Val Val Leu Asp Val Asn Asp His Val Pro 
225                 230                 235                 240 


Gln Phe Ser Arg Leu Val Tyr Arg Ala Gln Val Ser Glu Asn Ser Pro 
                245                 250                 255     


Asn Gly Ser Leu Val Ala Thr Val Thr Ala Val Asp Leu Asp Glu Gly 
            260                 265                 270         


Thr Asn Lys Ala Ile Thr Tyr Ser Leu Ala Gln Asn Pro Glu Ala Ile 
        275                 280                 285             


Leu Lys Thr Phe Gln Ile Asp Pro Gln Asn Gly Glu Val Arg Leu Arg 
    290                 295                 300                 


Gly Pro Leu Asp Phe Glu Ala Ile Glu Thr Tyr Asp Ile Asp Ile Gln 
305                 310                 315                 320 


Ala Thr Asp Gly Gly Gly Leu Ser Ala His Ser Lys Val Leu Val Glu 
                325                 330                 335     


Val Val Asp Val Asn Asp Asn Pro Pro Glu Val Met Val Ser Ser Val 
            340                 345                 350         


Ser Ser Pro Leu Pro Glu Asp Ser Pro Pro Gln Thr Val Val Ala Leu 
        355                 360                 365             


Phe Thr Ile Arg Asp Arg Asp Ile Arg Val Gly Gly Lys Val Thr Cys 
    370                 375                 380                 


Phe Leu Arg Glu Asp Leu Pro Phe Val Ile Lys Pro Thr Phe Gly Asn 
385                 390                 395                 400 


Ser Tyr Ser Leu Val Thr Asp Arg Ser Leu Asp Arg Glu Glu Val Ser 
                405                 410                 415     


Gly Tyr Asn Ile Thr Ile Val Ala Met Asp Thr Gly Pro Pro Ser Leu 
            420                 425                 430         


Ser Ala Glu Thr Met Ile Glu Val Leu Ile Ser Asp Val Asn Asp Asn 
        435                 440                 445             


Pro Pro Ile Phe Arg Glu Asp Ser Tyr Ile Leu Thr Val Arg Glu Asn 
    450                 455                 460                 


Asn Ser Pro Ala Val Phe Ile Gly Lys Val His Ala Glu Asp Leu Asp 
465                 470                 475                 480 


Leu Gly Glu Asn Ala Gln Ile Thr Tyr Ser Leu Leu Pro Pro Lys Asn 
                485                 490                 495     


Gly Asp Leu Ser Val Phe Ala Tyr Ile Ser Ile Asn Ser Gly Asn Gly 
            500                 505                 510         


Lys Leu Tyr Ala Leu Arg Thr Met Asp Tyr Glu Ala Ile Gln Asp Phe 
        515                 520                 525             


Gln Phe Val Val Lys Ala Thr Asp Gly Gly Phe Leu Ser Leu Ser Ser 
    530                 535                 540                 


Gln Val Thr Val Arg Val Val Val Leu Asp Asp Asn Asp Asn Arg Pro 
545                 550                 555                 560 


Met Ile Leu Tyr Pro Leu Gln Asn Gly Thr Leu Pro Cys Asn Asp Leu 
                565                 570                 575     


Val Pro Arg Ser Ala Glu Ala Gly Tyr Leu Val Thr Lys Val Val Ala 
            580                 585                 590         


Val Asp Gly Asp Ser Gly Gln Asn Ser Trp Leu Ser Tyr His Leu Leu 
        595                 600                 605             


Lys Ala Thr Asp Leu Gly Leu Phe Ser Val Gln Arg Gln Asn Gly Glu 
    610                 615                 620                 


Ile His Thr Leu Arg Gln Ile Ser Glu Arg Asp Pro Met Met Gln Lys 
625                 630                 635                 640 


Leu Ile Ile Leu Val Gln Asp His Gly Gln Pro Ala Leu Ser Thr Thr 
                645                 650                 655     


Val Ser Leu Asn Ile Leu Leu Val Asp Gly Phe Ser Glu Pro Tyr Leu 
            660                 665                 670         


Gln Phe Gln Asp Pro Thr Lys His Ser Arg Lys Val Asn Pro Ser Thr 
        675                 680                 685             


Lys Tyr Leu Val Ile Ser Leu Val Ile Leu Ser Phe Leu Phe Leu Leu 
    690                 695                 700                 


Ser Val Ile Val Ile Phe Ile Ile His Val Tyr Gln Lys Ile Lys Tyr 
705                 710                 715                 720 


Arg Glu Lys Phe Thr Ile Gln Glu His Phe Tyr Asp Asp Cys Asn Phe 
                725                 730                 735     


Ser Asn Asn Leu Val Gln Gly Gln Gly Asn Gly Ser Leu Ser Arg Pro 
            740                 745                 750         


Cys Pro Tyr Glu Met Cys Ser Ala Thr Gly Thr Gly Asn Ser Glu Phe 
        755                 760                 765             


Arg Phe Leu Lys Arg Phe Met Pro Asn Phe Pro Phe Pro His Ala Thr 
    770                 775                 780                 


Gly Glu Ile Lys Met Glu Ala Gly Ser Ser Leu Pro Pro Asn Ser Asp 
785                 790                 795                 800 


Arg Asn Lys Ser Gln Arg Leu Glu Gly His Asp Gln Val Ser Asp Asp 
                805                 810                 815     


Tyr Met 
        

<210>  275
<211>  2733
<212>  DNA
<213>  Homo sapiens

<400>  275
gctttctaag gcggtcgctc cgggaaatcc gggccctagg attgtccact catcccagta     60

tcagcgagat acggggagat agagttagcg acaacgtgag ccagagctgg agcacgtttg    120

gtgagagacc agaaagcaat ggaggccgga gaggggaagg agcgcgttcc gaaacaaagg    180

caagtcctga tattctttgt tttgctgggc atagctcagg ctagttgcca gcctaggcac    240

tattcagtgg ccgaggaaac ggagagtggc tcctttgtgg ccaatttgtt aaaagacctg    300

gggctggaga taggagaact tgctgtgagg ggggccaggg tcgtttccaa aggaaaaaaa    360

atgcatttgc agttcgatag gcagaccggg gatttgttgt taaatgagaa attggaccgg    420

gaggagctgt gcggccccac agagccctgt gtcctacctt tccaggtgtt actagaaaat    480

cccttgcagt tttttcaggc ggagctacgg attagggacg taaatgatca ttccccagtt    540

ttcctagaca aagaaatact tttgaaaatt ccagaaagta tcactcctgg aactactttc    600

ttaatagaac gtgcccagga cttggatgta ggaaccaaca gtctccaaaa ttacacaatc    660

agtcccaatt tccactttca tcttaattta caagacagtc tcgatggcat aatattacca    720

cagctggtgc tgaacagagc cctggatcgc gaggagcagc ctgagatcag gttaaccctc    780

acagcgctag atggcgggag tccacccagg tccggcacgg ccctggtacg gattgaagtt    840

gtggacatca atgacaacgt cccagagttt gcaaagctgc tctatgaggt gcagatcccg    900

gaggacagcc ccgttggatc ccaggttgcc atcgtctctg ccagggattt agacattgga    960

actaatggag aaatatctta tgcattttcc caagcatctg aagacattcg caaaacgttt   1020

cgattaagtg caaaatcggg agaactgctt ttaagacaga aactggattt cgaatccatc   1080

cagacataca cagtaaatat tcaggcgaca gatggtgggg gcctatctgg aacttgtgtg   1140

gtatttgtcc aagtgatgga tttgaatgac aatcctccgg aactaactat gtcgacactt   1200

atcaatcaga tcccagaaaa cttgcaggac accctcattg ctgtattcag cgtttcagat   1260

cctgactccg gagacaacgg aaggatggtg tgctccatcc aagatgatct tccttttttc   1320

ttgaaacctt ctgttgagaa cttttacact ctggtgataa gcacggccct ggaccgggag   1380

accagatccg aatacaacat caccatcacc gtcaccgact tcgggacacc caggctgaaa   1440

accgagcaca acataaccgt gctggtctcc gacgtcaatg acaacgcccc cgccttcacc   1500

caaacctcct acaccctgtt cgtccgcgag aacaacagcc ccgccctgca catcggcagc   1560

gtcagcgcca cagacagaga ctcgggcacc aacgcccagg tcacctactc gctgctgccg   1620

ccccaggacc cgcacctgcc cctcgcctcc ctggtctcca tcaacgcgga caacggccac   1680

ctgttcgctc tccagtcgct ggactacgag gccctgcagg cgttcgagtt ccgcgtgggc   1740

gccgcagacc gcggctcccc ggcgttgagc agcgaggcgc tggtgcgcgt gctggtgctg   1800

gacgccaacg acaactcgcc cttcgtgctg tacccgctgc agaacggctc cgcgccctgc   1860

accgagctgg tgccccgggc ggccgagccg ggctacctgg tgaccaaggt ggtggcggtg   1920

gacggcgact cgggccagaa cgcctggctg tcgtaccagc tgctcaaggc cacggagccc   1980

gggctgttcg gcgtgtgggc gcacaatggc gaggtgcgca ccgccaggct gctgagggag   2040

cgcgacgctg ccaagcagag gctggtggtg ctggtcaagg acaatggcga gcctccgcgc   2100

tcggccaccg ccacgctgca cgtgctcctg gtggacggct tctcccagcc ctacctgctg   2160

ctcccggagg cggcaccggc ccaggcccag gccgacttgc tcaccgtcta cctggtggtg   2220

gcgttggcct cggtgtcttc gctcttcctc ttctcggtgc tcctgttcgt ggcggtgcgg   2280

ctgtgcagga ggagcagggc ggcctcggtg ggtcgctgct cggtgcccga gggccccttt   2340

ccagggcaga tggtggacgt gagcggcacc gggaccctgt cccagagcta ccagtacgag   2400

gtgtgtctga ctggaggctc cgggacaaat gagttcaagt tcctgaagcc aattatcccc   2460

aacttcgttg ctcagggtgc agagagggtt agcgaggcaa atcccagttt caggaagagc   2520

tttgaattca cttaagtgtt aataaggatc tactgaggct agtctcgttt aatttgtgga   2580

aagtcctttt ttactgcttt gcccattgga ggtgtctcct tttattagaa agtaaccatc   2640

ttattccaat tctatgcatg ttactggtat ttataaatgt atgagttttt ttgcggtata   2700

ataaatgtaa attttctttg tattctaaaa aaa                                2733


<210>  276
<211>  798
<212>  PRT
<213>  Homo sapiens

<400>  276


Met Glu Ala Gly Glu Gly Lys Glu Arg Val Pro Lys Gln Arg Gln Val 
1               5                   10                  15      


Leu Ile Phe Phe Val Leu Leu Gly Ile Ala Gln Ala Ser Cys Gln Pro 
            20                  25                  30          


Arg His Tyr Ser Val Ala Glu Glu Thr Glu Ser Gly Ser Phe Val Ala 
        35                  40                  45              


Asn Leu Leu Lys Asp Leu Gly Leu Glu Ile Gly Glu Leu Ala Val Arg 
    50                  55                  60                  


Gly Ala Arg Val Val Ser Lys Gly Lys Lys Met His Leu Gln Phe Asp 
65                  70                  75                  80  


Arg Gln Thr Gly Asp Leu Leu Leu Asn Glu Lys Leu Asp Arg Glu Glu 
                85                  90                  95      


Leu Cys Gly Pro Thr Glu Pro Cys Val Leu Pro Phe Gln Val Leu Leu 
            100                 105                 110         


Glu Asn Pro Leu Gln Phe Phe Gln Ala Glu Leu Arg Ile Arg Asp Val 
        115                 120                 125             


Asn Asp His Ser Pro Val Phe Leu Asp Lys Glu Ile Leu Leu Lys Ile 
    130                 135                 140                 


Pro Glu Ser Ile Thr Pro Gly Thr Thr Phe Leu Ile Glu Arg Ala Gln 
145                 150                 155                 160 


Asp Leu Asp Val Gly Thr Asn Ser Leu Gln Asn Tyr Thr Ile Ser Pro 
                165                 170                 175     


Asn Phe His Phe His Leu Asn Leu Gln Asp Ser Leu Asp Gly Ile Ile 
            180                 185                 190         


Leu Pro Gln Leu Val Leu Asn Arg Ala Leu Asp Arg Glu Glu Gln Pro 
        195                 200                 205             


Glu Ile Arg Leu Thr Leu Thr Ala Leu Asp Gly Gly Ser Pro Pro Arg 
    210                 215                 220                 


Ser Gly Thr Ala Leu Val Arg Ile Glu Val Val Asp Ile Asn Asp Asn 
225                 230                 235                 240 


Val Pro Glu Phe Ala Lys Leu Leu Tyr Glu Val Gln Ile Pro Glu Asp 
                245                 250                 255     


Ser Pro Val Gly Ser Gln Val Ala Ile Val Ser Ala Arg Asp Leu Asp 
            260                 265                 270         


Ile Gly Thr Asn Gly Glu Ile Ser Tyr Ala Phe Ser Gln Ala Ser Glu 
        275                 280                 285             


Asp Ile Arg Lys Thr Phe Arg Leu Ser Ala Lys Ser Gly Glu Leu Leu 
    290                 295                 300                 


Leu Arg Gln Lys Leu Asp Phe Glu Ser Ile Gln Thr Tyr Thr Val Asn 
305                 310                 315                 320 


Ile Gln Ala Thr Asp Gly Gly Gly Leu Ser Gly Thr Cys Val Val Phe 
                325                 330                 335     


Val Gln Val Met Asp Leu Asn Asp Asn Pro Pro Glu Leu Thr Met Ser 
            340                 345                 350         


Thr Leu Ile Asn Gln Ile Pro Glu Asn Leu Gln Asp Thr Leu Ile Ala 
        355                 360                 365             


Val Phe Ser Val Ser Asp Pro Asp Ser Gly Asp Asn Gly Arg Met Val 
    370                 375                 380                 


Cys Ser Ile Gln Asp Asp Leu Pro Phe Phe Leu Lys Pro Ser Val Glu 
385                 390                 395                 400 


Asn Phe Tyr Thr Leu Val Ile Ser Thr Ala Leu Asp Arg Glu Thr Arg 
                405                 410                 415     


Ser Glu Tyr Asn Ile Thr Ile Thr Val Thr Asp Phe Gly Thr Pro Arg 
            420                 425                 430         


Leu Lys Thr Glu His Asn Ile Thr Val Leu Val Ser Asp Val Asn Asp 
        435                 440                 445             


Asn Ala Pro Ala Phe Thr Gln Thr Ser Tyr Thr Leu Phe Val Arg Glu 
    450                 455                 460                 


Asn Asn Ser Pro Ala Leu His Ile Gly Ser Val Ser Ala Thr Asp Arg 
465                 470                 475                 480 


Asp Ser Gly Thr Asn Ala Gln Val Thr Tyr Ser Leu Leu Pro Pro Gln 
                485                 490                 495     


Asp Pro His Leu Pro Leu Ala Ser Leu Val Ser Ile Asn Ala Asp Asn 
            500                 505                 510         


Gly His Leu Phe Ala Leu Gln Ser Leu Asp Tyr Glu Ala Leu Gln Ala 
        515                 520                 525             


Phe Glu Phe Arg Val Gly Ala Ala Asp Arg Gly Ser Pro Ala Leu Ser 
    530                 535                 540                 


Ser Glu Ala Leu Val Arg Val Leu Val Leu Asp Ala Asn Asp Asn Ser 
545                 550                 555                 560 


Pro Phe Val Leu Tyr Pro Leu Gln Asn Gly Ser Ala Pro Cys Thr Glu 
                565                 570                 575     


Leu Val Pro Arg Ala Ala Glu Pro Gly Tyr Leu Val Thr Lys Val Val 
            580                 585                 590         


Ala Val Asp Gly Asp Ser Gly Gln Asn Ala Trp Leu Ser Tyr Gln Leu 
        595                 600                 605             


Leu Lys Ala Thr Glu Pro Gly Leu Phe Gly Val Trp Ala His Asn Gly 
    610                 615                 620                 


Glu Val Arg Thr Ala Arg Leu Leu Arg Glu Arg Asp Ala Ala Lys Gln 
625                 630                 635                 640 


Arg Leu Val Val Leu Val Lys Asp Asn Gly Glu Pro Pro Arg Ser Ala 
                645                 650                 655     


Thr Ala Thr Leu His Val Leu Leu Val Asp Gly Phe Ser Gln Pro Tyr 
            660                 665                 670         


Leu Leu Leu Pro Glu Ala Ala Pro Ala Gln Ala Gln Ala Asp Leu Leu 
        675                 680                 685             


Thr Val Tyr Leu Val Val Ala Leu Ala Ser Val Ser Ser Leu Phe Leu 
    690                 695                 700                 


Phe Ser Val Leu Leu Phe Val Ala Val Arg Leu Cys Arg Arg Ser Arg 
705                 710                 715                 720 


Ala Ala Ser Val Gly Arg Cys Ser Val Pro Glu Gly Pro Phe Pro Gly 
                725                 730                 735     


Gln Met Val Asp Val Ser Gly Thr Gly Thr Leu Ser Gln Ser Tyr Gln 
            740                 745                 750         


Tyr Glu Val Cys Leu Thr Gly Gly Ser Gly Thr Asn Glu Phe Lys Phe 
        755                 760                 765             


Leu Lys Pro Ile Ile Pro Asn Phe Val Ala Gln Gly Ala Glu Arg Val 
    770                 775                 780                 


Ser Glu Ala Asn Pro Ser Phe Arg Lys Ser Phe Glu Phe Thr 
785                 790                 795             

<210>  277
<211>  3173
<212>  DNA
<213>  Homo sapiens

<400>  277
atggaggcgg gaggagagcg atttcttaga caaaggcaag tcttgcttct ctttgttttt     60

ctgggagggt ctctggctgg gtccgagtca agacgctatt ctgtggctga ggaaaaagag    120

aagggctttt taatagccaa cctagcaaag gatctgggac taagggtaga ggaactggcc    180

gcgagggggg cccaagttgt gtccaaaggg aacaaacagc attttcagct cagtcatcag    240

acaggtgatt tgctcctgaa tgagaaattg gaccgggagg agctatgcgg ccccacagaa    300

ccatgcatac tacattttca gatattactg caaaaccctt tgcaattcgt tacaaacgag    360

ctccgtatca tagatgtaaa tgaccattct ccggtattct ttgaaaatga aatgcatctg    420

aaaatcctag aaagcactct gccaggaaca gtaattcctt tgggaaatgc tgaggacttg    480

gatgtgggaa gaaacagcct ccaaaactac actatcactc cgaattccca cttccacgta    540

ctcactcgca gtcgtaggga cggaaggaag tacccggaac tagtactgga taaagcgctc    600

gatcgggagg agcagccgga actcagctta acgctcaccg cgctggacgg cggctctccc    660

cctcggtctg ggacagccca gataaacatc caggtcttag atataaacga caatgcacca    720

gaatttgcac agccgctcta tgaggttgca gttctagaga atacccccgt taactctgtc    780

attgtcactg tctcggcttc tgacttagat acaggaagtt ttgggacaat atcatatgca    840

ttttttcatg cttctgaaga aattcgcaaa acttttcagc taaatccaat tactggtgat    900

atgcaactgg tcaaatattt gaattttgaa gcgattaata gttatgaagt cgacatcgag    960

gccaaggatg gcggaggcct atccggaaag tctacagtca tagtccaggt ggttgatgtc   1020

aacgacaacc caccggaact gaccttgtct tcagtaaaca gccctattcc tgagaactcg   1080

ggagagactg tactggctgt tttcagtgtt tctgatctag actctggaga caacggaaga   1140

gtgatgtgtt ccattgagaa caatctcccc ttcttcctga aaccatctgt agagaatttt   1200

tacaccctag tgtcagaagg cgcgctggac agagagacca gatccgagta caacattacc   1260

atcactatca ctgacctggg gacacccagg ctgaaaacca agtacaacat aaccgtgctg   1320

gtctccgacg tcaatgacaa cgcccccgcc ttcacccaaa tctcctacac cctgttcgtc   1380

cgcgagaaca acagccccgc cctgcacatc ggcagtgtca gcgccacaga cagagactca   1440

ggcaccaacg cccaggtaac ctactcgctg ctgccgcccc aggacccgca cctgcccctc   1500

tcttccctgg tctccatcaa cgcggacaac ggccacctgt ttgccctcag gtcgctggac   1560

tacgaggccc tgcaggcgtt cgagttccgc gtgggcgcca cagaccgtgg ctccccggct   1620

ttgagcagcg aggcgctggt gcgcgtgctg gtgctggacg ccaacgacaa ctcgcccttc   1680

gtgctgtacc cgctgcagaa cggctccgcg ccctgcaccg agctggtgcc ccgggcggct   1740

gagccgggct acctggtgac caaggtggtg gcggtggacg gcgactcggg ccagaacgcc   1800

tggctgtcgt accagctgct caaggccacg gagcccgggc tgttcggcgt gtgggcgcac   1860

aatggcgaag tgcgcaccgc caggctgctg agcgagcgcg acgcggccaa gcacaggctg   1920

gtggtgctgg tcaaggacaa tggcgagcct ccgcgctcgg ccaccgccac gctgcatgtg   1980

ctcctggtgg acggcttctc ccagccctac ctgcctctcc cggaggcggc accggcccag   2040

gcccaggccg acttgctcac cgtctacctg gtggtggcat tggcctcggt gtcttcgctc   2100

ttcctctttt cggtgctcct gttcgtggcg gtgcggctgt gcaggaggag cagggcggcc   2160

tcggtgggtc gctgctcggt gcccgagggc ccctttccag ggcagatggt ggacgtgagc   2220

ggcaccggga ccctgtccca gagctaccag tacgaggtgt gtctgactgg aggctccggg   2280

acaaatgagt tcaagttcct gaagccaatt atccccaact tcgttgctca gggtgcagag   2340

agggttagcg aggcaaatcc cagtttcagg aagagctttg aattcagtta agtgttaata   2400

aggatctact gagcctcgtc ttagttaatc tgtggaaagt ccttttttac tgctttgtcc   2460

attggagagg tcttttttgg tctggttcaa ggcaagtagc aagaatagag caaaatatca   2520

aatccaggga tggcttaggt ttcattaaca gtactggaaa gtagttgtgt ggctctgaat   2580

gttttgtatt tcaatcgaga atccttagtc gatagaacat tttgtttata tattgattct   2640

actttttctg tagttaatcc ttgcatattc tcctttcatc ctggcttgcc aacgcagtct   2700

taattccgcc tttttttttt ctaatgggga gcaaaaagaa attcactgtc ttttaatagt   2760

gatttcaaat agcttattaa aataactcca ttcaaatttt acattataaa gcaatgtaga   2820

gagagttcca aaccaccaat tttataattt cccttgttga atatattcat ataatgtgtt   2880

ctataatatg cccaaagcag ctttgtctat agttaacaaa gttttaagga tagacaagaa   2940

tgtgttttct ttaataaata gtaatatatc atctttttag ggatatagta ctcaaatgaa   3000

agtaatttag ttcattttct gtgttgacat ttgcaattaa tatttcaata ttttatgtgc   3060

ttatattggc caaaatatgg acacaaatat agactaatat gggtaattac cctttggttt   3120

atctaaagtg tgttcatgat gactgaggaa aaaaattaaa cctatgccat tta          3173


<210>  278
<211>  796
<212>  PRT
<213>  Homo sapiens

<400>  278


Met Glu Ala Gly Gly Glu Arg Phe Leu Arg Gln Arg Gln Val Leu Leu 
1               5                   10                  15      


Leu Phe Val Phe Leu Gly Gly Ser Leu Ala Gly Ser Glu Ser Arg Arg 
            20                  25                  30          


Tyr Ser Val Ala Glu Glu Lys Glu Lys Gly Phe Leu Ile Ala Asn Leu 
        35                  40                  45              


Ala Lys Asp Leu Gly Leu Arg Val Glu Glu Leu Ala Ala Arg Gly Ala 
    50                  55                  60                  


Gln Val Val Ser Lys Gly Asn Lys Gln His Phe Gln Leu Ser His Gln 
65                  70                  75                  80  


Thr Gly Asp Leu Leu Leu Asn Glu Lys Leu Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Gly Pro Thr Glu Pro Cys Ile Leu His Phe Gln Ile Leu Leu Gln Asn 
            100                 105                 110         


Pro Leu Gln Phe Val Thr Asn Glu Leu Arg Ile Ile Asp Val Asn Asp 
        115                 120                 125             


His Ser Pro Val Phe Phe Glu Asn Glu Met His Leu Lys Ile Leu Glu 
    130                 135                 140                 


Ser Thr Leu Pro Gly Thr Val Ile Pro Leu Gly Asn Ala Glu Asp Leu 
145                 150                 155                 160 


Asp Val Gly Arg Asn Ser Leu Gln Asn Tyr Thr Ile Thr Pro Asn Ser 
                165                 170                 175     


His Phe His Val Leu Thr Arg Ser Arg Arg Asp Gly Arg Lys Tyr Pro 
            180                 185                 190         


Glu Leu Val Leu Asp Lys Ala Leu Asp Arg Glu Glu Gln Pro Glu Leu 
        195                 200                 205             


Ser Leu Thr Leu Thr Ala Leu Asp Gly Gly Ser Pro Pro Arg Ser Gly 
    210                 215                 220                 


Thr Ala Gln Ile Asn Ile Gln Val Leu Asp Ile Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Glu Phe Ala Gln Pro Leu Tyr Glu Val Ala Val Leu Glu Asn Thr Pro 
                245                 250                 255     


Val Asn Ser Val Ile Val Thr Val Ser Ala Ser Asp Leu Asp Thr Gly 
            260                 265                 270         


Ser Phe Gly Thr Ile Ser Tyr Ala Phe Phe His Ala Ser Glu Glu Ile 
        275                 280                 285             


Arg Lys Thr Phe Gln Leu Asn Pro Ile Thr Gly Asp Met Gln Leu Val 
    290                 295                 300                 


Lys Tyr Leu Asn Phe Glu Ala Ile Asn Ser Tyr Glu Val Asp Ile Glu 
305                 310                 315                 320 


Ala Lys Asp Gly Gly Gly Leu Ser Gly Lys Ser Thr Val Ile Val Gln 
                325                 330                 335     


Val Val Asp Val Asn Asp Asn Pro Pro Glu Leu Thr Leu Ser Ser Val 
            340                 345                 350         


Asn Ser Pro Ile Pro Glu Asn Ser Gly Glu Thr Val Leu Ala Val Phe 
        355                 360                 365             


Ser Val Ser Asp Leu Asp Ser Gly Asp Asn Gly Arg Val Met Cys Ser 
    370                 375                 380                 


Ile Glu Asn Asn Leu Pro Phe Phe Leu Lys Pro Ser Val Glu Asn Phe 
385                 390                 395                 400 


Tyr Thr Leu Val Ser Glu Gly Ala Leu Asp Arg Glu Thr Arg Ser Glu 
                405                 410                 415     


Tyr Asn Ile Thr Ile Thr Ile Thr Asp Leu Gly Thr Pro Arg Leu Lys 
            420                 425                 430         


Thr Lys Tyr Asn Ile Thr Val Leu Val Ser Asp Val Asn Asp Asn Ala 
        435                 440                 445             


Pro Ala Phe Thr Gln Ile Ser Tyr Thr Leu Phe Val Arg Glu Asn Asn 
    450                 455                 460                 


Ser Pro Ala Leu His Ile Gly Ser Val Ser Ala Thr Asp Arg Asp Ser 
465                 470                 475                 480 


Gly Thr Asn Ala Gln Val Thr Tyr Ser Leu Leu Pro Pro Gln Asp Pro 
                485                 490                 495     


His Leu Pro Leu Ser Ser Leu Val Ser Ile Asn Ala Asp Asn Gly His 
            500                 505                 510         


Leu Phe Ala Leu Arg Ser Leu Asp Tyr Glu Ala Leu Gln Ala Phe Glu 
        515                 520                 525             


Phe Arg Val Gly Ala Thr Asp Arg Gly Ser Pro Ala Leu Ser Ser Glu 
    530                 535                 540                 


Ala Leu Val Arg Val Leu Val Leu Asp Ala Asn Asp Asn Ser Pro Phe 
545                 550                 555                 560 


Val Leu Tyr Pro Leu Gln Asn Gly Ser Ala Pro Cys Thr Glu Leu Val 
                565                 570                 575     


Pro Arg Ala Ala Glu Pro Gly Tyr Leu Val Thr Lys Val Val Ala Val 
            580                 585                 590         


Asp Gly Asp Ser Gly Gln Asn Ala Trp Leu Ser Tyr Gln Leu Leu Lys 
        595                 600                 605             


Ala Thr Glu Pro Gly Leu Phe Gly Val Trp Ala His Asn Gly Glu Val 
    610                 615                 620                 


Arg Thr Ala Arg Leu Leu Ser Glu Arg Asp Ala Ala Lys His Arg Leu 
625                 630                 635                 640 


Val Val Leu Val Lys Asp Asn Gly Glu Pro Pro Arg Ser Ala Thr Ala 
                645                 650                 655     


Thr Leu His Val Leu Leu Val Asp Gly Phe Ser Gln Pro Tyr Leu Pro 
            660                 665                 670         


Leu Pro Glu Ala Ala Pro Ala Gln Ala Gln Ala Asp Leu Leu Thr Val 
        675                 680                 685             


Tyr Leu Val Val Ala Leu Ala Ser Val Ser Ser Leu Phe Leu Phe Ser 
    690                 695                 700                 


Val Leu Leu Phe Val Ala Val Arg Leu Cys Arg Arg Ser Arg Ala Ala 
705                 710                 715                 720 


Ser Val Gly Arg Cys Ser Val Pro Glu Gly Pro Phe Pro Gly Gln Met 
                725                 730                 735     


Val Asp Val Ser Gly Thr Gly Thr Leu Ser Gln Ser Tyr Gln Tyr Glu 
            740                 745                 750         


Val Cys Leu Thr Gly Gly Ser Gly Thr Asn Glu Phe Lys Phe Leu Lys 
        755                 760                 765             


Pro Ile Ile Pro Asn Phe Val Ala Gln Gly Ala Glu Arg Val Ser Glu 
    770                 775                 780                 


Ala Asn Pro Ser Phe Arg Lys Ser Phe Glu Phe Ser 
785                 790                 795     

<210>  279
<211>  3621
<212>  DNA
<213>  Homo sapiens

<400>  279
atgaagaagc tagggagaat tcatccaaac aggcaagtgt tggcctttat tttgatggtg     60

ttcttgtctc aggttcgcct cgagcctatt cgttattctg tgttggagga aacagagagc    120

ggctcctttg tagcccatct ggccaaggat ctgggcctgg gaattgggga actggcctcc    180

cggtcagccc gggtgctgtc tgacgatgac aagcagcgtt tgcagctgga tcgtcagact    240

ggagatttgc ttctgaggga gaaactagac cgggaagagc tctgtggtcc tattgaaccg    300

tgtgtactgc atttccaagt gttcctggaa atgccggtgc aattttttca aggagaatta    360

ttgatccagg acataaatga tcactctcca atattccctg aaagggaagt gctcttgaaa    420

atactagaaa atagccagcc gggtactcta tttccgttgc taatagctga ggatttggat    480

gtgggcagca atggtcttca aaaatacaca atcagcccca attctcattt tcacattctc    540

actcgaaatc atagtgaggg caagaaatac ccagatttgg tgcaggacaa accactggat    600

cgagaggagc agcctgagtt cagcttaacc ctcgtggcgc tggatggtgg gtcaccacct    660

aggtctggca cggtcatggt tcgaatcctg atcatggaca tcaatgacaa tgctcctgag    720

tttgtgcaca ctccatatgg ggtgcaggtc ctggaaaaca gccccctaga ctctccaatt    780

gttagggtct tagctagaga tatagatgct ggaaacttcg ggagtgtttc ttatggctta    840

ttccaagcat cagatgaaat taaacaaact ttctcaataa atgaagtcac gggagaaata    900

ctgttgaaaa aaaaattgga tttcgaaaaa attaaatctt accatgtaga aattgaggcc    960

acagatggag gaggcctttc tggaaaaggc actgtagtca tagaggtggt ggatgtgaat   1020

gacaatcccc cagaacttat catatcttca ctcaccagct ccatcccaga aaatgctcct   1080

gagacggtag tctctatctt ccgaattcga gatagagatt ccggagaaaa tggaaagatg   1140

atttgctcta ttccagataa tctaccgttt attctaaaac caactttgaa gaatttttac   1200

accctggtaa cagagagacc actggaccga gagaccagcg ctgagtacaa catcaccatc   1260

gccgtcactg acttggggac acccaggctg aaaacccagc agaacataac cgtgcaggtc   1320

tccgacgtca atgacaacgc ccccgccttc acccaaacct cctacaccct gttcgtccgc   1380

gagaacaaca gccccgccct gcacatcggc agtgtcagcg ccacagacag agactcgggc   1440

accaacgccc aggtcaccta ctcgctgctg ccgccccagg acccgcacct gcccctcgcc   1500

tccctggtct ccatcaacgc agacaacggc cacctgttcg ccctcaggtc gctggactac   1560

gaggccctgc aggcgttcga gttccgcgtg ggcgcctcag accgcggttc tccggctttg   1620

agcagcgagg cgctggtgcg cgtgctggtg ctggacacca acgacaactc gcccttcgtg   1680

ctgtacccgc tgcagaatgg ctccgcgccc tgcaccgagc tggtgccccg ggcggccgag   1740

ccgggctacc tggtgaccaa ggtggtggcg gtggacggcg actcgggcca gaacgcctgg   1800

ctgtcgtacc agctgctcaa ggccacggag cctgggctgt tcggcgtgtg ggcgcacaat   1860

ggcgaggtgc gcaccgccag gctgctgagc gagcgcgacg cagccaagca caggctcgtg   1920

gtgcttgtca aggacaatgg cgagcctccg cgctcggcca ccgccacgct gcacgtgctc   1980

ctggtggatg gcttctccca gccctacctg cctctccctg aggcggcccc ggcccaggcc   2040

caggccgact ctctcaccgt ctacctggtg gtggcgttgg cctcggtgtc gtcgctcttc   2100

ctcttctcgg tgctcctgtt cgtggcggtg cggctgtgca ggaggagcag ggcggcctcg   2160

gtgggtcgct gctcggtgcc cgagggcccc tttccagggc atctggtgga cgtaagcggc   2220

accgggaccc tgtcccagag ctaccagtac gaggtgtgtc tgacaggaga ctctgggact   2280

ggtgagttca agttcctgaa gccaatattt cctaatctct tggttcagga caccgggagg   2340

gaagttaagg aaaaccccaa gttcagaaat agcttggtat tcagttaagt attgtattta   2400

gttcagtgaa ccgcccgtta gttttgtcaa acttcccact gcaatgcctt tatttaaaaa   2460

aattgtctac ttatctaaat attcatacca caatttcaaa cctactcatg tccctgataa   2520

agctaaattt gtcccttttt tattgttatt aattgcactt aacattttta gttatactgg   2580

atattgagta tggattttct ctatatttga tctattggtg attaatcttt ttgtaatcat   2640

aaattactca attaggataa aaataaatta tgttttaatg aaattcttaa attaacatct   2700

ttttaatgga acatttaagt gaatatatga atattgaatt tctaaatatt tgttgtgcct   2760

gtctttacca tgtaacttaa tgtttgcaag gccagagtgt ttgaaagttt tgtatttaac   2820

tttataatta ccttgtcctt tctggttgac tatactaggc taagccctct taatagccat   2880

gagtgtaaaa tttagtttac tcatttttca caaattgtat ataaacatgc acttcactac   2940

attggtaata cactaaaatt gtggtccttt tcctcttgtg accaccacat gtctagtgat   3000

tattttgttt atttggttgc tacttaccta gcacattgta atgttccatg aatgctaata   3060

ttaaattttg taaaaataac ttatttataa ataattttta aagagaaaaa tctcatataa   3120

tttgtcataa cctttcaata aataaaactg ttaaatcatg gcctgatatc atcttaaaaa   3180

aaaatctcag aatctgaaat aagccctaaa tttctcccca aaatcaagac tcttgagagc   3240

atcataggtc tccttgtgct accttttact ccctataaat agaaatccaa gtatacttta   3300

atatgtgtat attttttggt tttcctacag cttctcccca tctttcaaaa gaatcacgaa   3360

atttcttctg caccttggct attctgttta aatctgataa tcagttgatc tcaggttttt   3420

cactgtacat tactttgcag atatggacag cctttacaaa aataattttt aaatgcttaa   3480

ttattttaat ttgttcttta aggtaacctt cagttatttt gaattaattt aacttctcaa   3540

ttatgccaaa gttgcacttg catgaaataa atattatttt gtccttgtat agactggaac   3600

agtaataaat ttatctgaat t                                             3621


<210>  280
<211>  795
<212>  PRT
<213>  Homo sapiens

<400>  280


Met Lys Lys Leu Gly Arg Ile His Pro Asn Arg Gln Val Leu Ala Phe 
1               5                   10                  15      


Ile Leu Met Val Phe Leu Ser Gln Val Arg Leu Glu Pro Ile Arg Tyr 
            20                  25                  30          


Ser Val Leu Glu Glu Thr Glu Ser Gly Ser Phe Val Ala His Leu Ala 
        35                  40                  45              


Lys Asp Leu Gly Leu Gly Ile Gly Glu Leu Ala Ser Arg Ser Ala Arg 
    50                  55                  60                  


Val Leu Ser Asp Asp Asp Lys Gln Arg Leu Gln Leu Asp Arg Gln Thr 
65                  70                  75                  80  


Gly Asp Leu Leu Leu Arg Glu Lys Leu Asp Arg Glu Glu Leu Cys Gly 
                85                  90                  95      


Pro Ile Glu Pro Cys Val Leu His Phe Gln Val Phe Leu Glu Met Pro 
            100                 105                 110         


Val Gln Phe Phe Gln Gly Glu Leu Leu Ile Gln Asp Ile Asn Asp His 
        115                 120                 125             


Ser Pro Ile Phe Pro Glu Arg Glu Val Leu Leu Lys Ile Leu Glu Asn 
    130                 135                 140                 


Ser Gln Pro Gly Thr Leu Phe Pro Leu Leu Ile Ala Glu Asp Leu Asp 
145                 150                 155                 160 


Val Gly Ser Asn Gly Leu Gln Lys Tyr Thr Ile Ser Pro Asn Ser His 
                165                 170                 175     


Phe His Ile Leu Thr Arg Asn His Ser Glu Gly Lys Lys Tyr Pro Asp 
            180                 185                 190         


Leu Val Gln Asp Lys Pro Leu Asp Arg Glu Glu Gln Pro Glu Phe Ser 
        195                 200                 205             


Leu Thr Leu Val Ala Leu Asp Gly Gly Ser Pro Pro Arg Ser Gly Thr 
    210                 215                 220                 


Val Met Val Arg Ile Leu Ile Met Asp Ile Asn Asp Asn Ala Pro Glu 
225                 230                 235                 240 


Phe Val His Thr Pro Tyr Gly Val Gln Val Leu Glu Asn Ser Pro Leu 
                245                 250                 255     


Asp Ser Pro Ile Val Arg Val Leu Ala Arg Asp Ile Asp Ala Gly Asn 
            260                 265                 270         


Phe Gly Ser Val Ser Tyr Gly Leu Phe Gln Ala Ser Asp Glu Ile Lys 
        275                 280                 285             


Gln Thr Phe Ser Ile Asn Glu Val Thr Gly Glu Ile Leu Leu Lys Lys 
    290                 295                 300                 


Lys Leu Asp Phe Glu Lys Ile Lys Ser Tyr His Val Glu Ile Glu Ala 
305                 310                 315                 320 


Thr Asp Gly Gly Gly Leu Ser Gly Lys Gly Thr Val Val Ile Glu Val 
                325                 330                 335     


Val Asp Val Asn Asp Asn Pro Pro Glu Leu Ile Ile Ser Ser Leu Thr 
            340                 345                 350         


Ser Ser Ile Pro Glu Asn Ala Pro Glu Thr Val Val Ser Ile Phe Arg 
        355                 360                 365             


Ile Arg Asp Arg Asp Ser Gly Glu Asn Gly Lys Met Ile Cys Ser Ile 
    370                 375                 380                 


Pro Asp Asn Leu Pro Phe Ile Leu Lys Pro Thr Leu Lys Asn Phe Tyr 
385                 390                 395                 400 


Thr Leu Val Thr Glu Arg Pro Leu Asp Arg Glu Thr Ser Ala Glu Tyr 
                405                 410                 415     


Asn Ile Thr Ile Ala Val Thr Asp Leu Gly Thr Pro Arg Leu Lys Thr 
            420                 425                 430         


Gln Gln Asn Ile Thr Val Gln Val Ser Asp Val Asn Asp Asn Ala Pro 
        435                 440                 445             


Ala Phe Thr Gln Thr Ser Tyr Thr Leu Phe Val Arg Glu Asn Asn Ser 
    450                 455                 460                 


Pro Ala Leu His Ile Gly Ser Val Ser Ala Thr Asp Arg Asp Ser Gly 
465                 470                 475                 480 


Thr Asn Ala Gln Val Thr Tyr Ser Leu Leu Pro Pro Gln Asp Pro His 
                485                 490                 495     


Leu Pro Leu Ala Ser Leu Val Ser Ile Asn Ala Asp Asn Gly His Leu 
            500                 505                 510         


Phe Ala Leu Arg Ser Leu Asp Tyr Glu Ala Leu Gln Ala Phe Glu Phe 
        515                 520                 525             


Arg Val Gly Ala Ser Asp Arg Gly Ser Pro Ala Leu Ser Ser Glu Ala 
    530                 535                 540                 


Leu Val Arg Val Leu Val Leu Asp Thr Asn Asp Asn Ser Pro Phe Val 
545                 550                 555                 560 


Leu Tyr Pro Leu Gln Asn Gly Ser Ala Pro Cys Thr Glu Leu Val Pro 
                565                 570                 575     


Arg Ala Ala Glu Pro Gly Tyr Leu Val Thr Lys Val Val Ala Val Asp 
            580                 585                 590         


Gly Asp Ser Gly Gln Asn Ala Trp Leu Ser Tyr Gln Leu Leu Lys Ala 
        595                 600                 605             


Thr Glu Pro Gly Leu Phe Gly Val Trp Ala His Asn Gly Glu Val Arg 
    610                 615                 620                 


Thr Ala Arg Leu Leu Ser Glu Arg Asp Ala Ala Lys His Arg Leu Val 
625                 630                 635                 640 


Val Leu Val Lys Asp Asn Gly Glu Pro Pro Arg Ser Ala Thr Ala Thr 
                645                 650                 655     


Leu His Val Leu Leu Val Asp Gly Phe Ser Gln Pro Tyr Leu Pro Leu 
            660                 665                 670         


Pro Glu Ala Ala Pro Ala Gln Ala Gln Ala Asp Ser Leu Thr Val Tyr 
        675                 680                 685             


Leu Val Val Ala Leu Ala Ser Val Ser Ser Leu Phe Leu Phe Ser Val 
    690                 695                 700                 


Leu Leu Phe Val Ala Val Arg Leu Cys Arg Arg Ser Arg Ala Ala Ser 
705                 710                 715                 720 


Val Gly Arg Cys Ser Val Pro Glu Gly Pro Phe Pro Gly His Leu Val 
                725                 730                 735     


Asp Val Ser Gly Thr Gly Thr Leu Ser Gln Ser Tyr Gln Tyr Glu Val 
            740                 745                 750         


Cys Leu Thr Gly Asp Ser Gly Thr Gly Glu Phe Lys Phe Leu Lys Pro 
        755                 760                 765             


Ile Phe Pro Asn Leu Leu Val Gln Asp Thr Gly Arg Glu Val Lys Glu 
    770                 775                 780                 


Asn Pro Lys Phe Arg Asn Ser Leu Val Phe Ser 
785                 790                 795 

<210>  281
<211>  2925
<212>  DNA
<213>  Homo sapiens

<400>  281
agtgggctct gcggataact cagacgccat taagctgggg aatccaaact ctaaaagaag     60

gacgcatttt aggtaagatc tagtggctag atcttcaggg tgggcttcgt tcttgtggaa    120

atcagtcaag aaagatcgga ttcgcggtta tttatgcaaa tcatctgggt ggattgtgta    180

cggagttaaa ctgcgccttc tggaccgggt ctgaacaatg gagactgcgc tagcaaaaac    240

gccacagaaa aggcaagtta tgtttcttgc tatattgttg cttttgtggg aggctggctc    300

tgaggcagtt aggtattcca taccagaaga aacagaaagt ggctattctg tggccaacct    360

ggcaaaagac ctgggtcttg gggtggggga actggccact cggggcgcgc gaatgcatta    420

caaaggaaac aaagagctct tgcagcttga tataaagacc ggcaatttgc ttctatatga    480

aaaactagac cgggaggtga tgtgcggggc gacagaaccc tgtatattgc atttccagct    540

cttactagaa aatccagtgc agttttttca aactgatctg cagctcacag atataaatga    600

ccatgcccca gagttcccag agaaggaaat gctcctaaaa atcccagaga gcacccagcc    660

agggactgtg tttcccttaa aaatagccca ggactttgac ataggtagca acactgttca    720

gaactacaca atcagcccaa attcacactt tcatgttgct acgcataatc gcggagatgg    780

cagaaaatac ccagagctgg tgctggacaa agcgctggac cgggaggagc ggcctgagct    840

cagcttaaca ctcactgcac tggacggtgg ggctccgccc aggtccggga ccaccacaat    900

tcgcattgtc gtcttggata ataatgacaa cgcccccgaa tttttacaat cattctatga    960

ggtacaggtg cccgagaaca gcccccttaa ctccttagtt gtcgttgtct ccgctcgaga   1020

tttagatgca ggagcatatg ggagtgtagc ctatgctcta ttccaaggcg atgaagttac   1080

tcaaccattt gtaatagacg agaaaacagc agaaattcgc ctgaaaaggg cattggattt   1140

cgaggcaact ccatattata acgtggaaat tgtagccaca gatggtgggg gcctttcagg   1200

aaaatgcact gtggctatag aagtggtgga tgtgaatgac aacgcccctg aactcaccat   1260

gtctacgctc tccagcccta ccccagaaaa tgccccggaa actgtagttg ccgttttcag   1320

tgtttctgat ccagactccg gggacaacgg taggatgatt tgctccatcc agaatgatct   1380

cccctttctt ttgaagccca cattaaaaaa cttttacacc ctagtgacac agagaacact   1440

ggacagagag agccaagccg agtacaacat caccatcact gtcaccgaca tggggacacc   1500

caggctgaaa accgagcaca acataacggt cctggtctcc gacgtcaatg acaacgcccc   1560

cgccttcacc caaacctcct acaccctgtt cgtccgagag aacaacagcc ccgccctgca   1620

catcggcagt gtcagcgcca cagacagaga ctcaggcacc aacgcccagg tcacctactc   1680

gctgctgccg ccccagaacc cacacctgcg cctcgcctcc ctggtctcca tcaacgcgga   1740

caacggccac ctgtttgccc tcaggtcgct ggactacgag gccctgcagg cgttcgagtt   1800

ccgcgtggga gccacagacc gcggctcccc ggcgctgagc agcgaggcgc tggtgcgcgt   1860

gctggtgctg gacgccaacg acaactcgcc cttcgtgctg tatccgctgc agaacggctc   1920

ggcgccttgc accgagctgg tgccccgggc ggccgagccg ggctacctgg tgaccaaggt   1980

ggtggcggtg gacggcgact cgggccagaa cgcctggctg tcgtaccagc tgctcaaggc   2040

cacggagccc gggctgttca gcatgtgggc gcacaatggc gaggtgcgca ccgccaggct   2100

gctgagcgag cgcgacgcgg ccaagcacag gctggtggtg ctggtcaagg acaatggcga   2160

gcctccgcgc tcggccaccg ccacgctgca cgtgctcctg gtggacggct tctcccagcc   2220

ctacctgccg ctgccggagg cggccccggc ccaggcccag gccgactcgc tcactgtcta   2280

cctggtggtg gcattggcct cggtgtcgtc gctcttcctc ttttcggtgc tcctgttcgt   2340

ggcagtgcgg ctgtgcagga ggagcagggc ggcctcggtc ggtcgctgct cggtgcccga   2400

gggccccttt ccagggcatc tggtggacgt gagcggcacc gggaccctat cccagagcta   2460

ccactacgag gtgtgtttga ccggagactc aggggccggc gagttcaagt tcctgaagcc   2520

gattattcct aaccttttgc cccagggcgc tggtgaagaa atagggaaaa ctgctgcctt   2580

ccggaatagc tttggattaa attagagatc tcgtgatgac gcgttgtttt ctgccattta   2640

tcccaaactt tttcagatct agaattcgag agtgtcatgg acaaaaattt caccttgaga   2700

ttgagctttt atttcccttt ttaatggatt tgtctgttga acttcatgct gtccaagtgt   2760

tgaaaagtca attttatttc attgcattta tttacatagt gtcattccaa atccatgcat   2820

gctgttgatt ttcctgagat ttttttctct tcttgttggt atttgttgtg ataaaccacc   2880

ttaataaaat caagtattaa ttttaaaaaa aaaaaaaaaa aaaaa                   2925


<210>  282
<211>  795
<212>  PRT
<213>  Homo sapiens

<400>  282


Met Glu Thr Ala Leu Ala Lys Thr Pro Gln Lys Arg Gln Val Met Phe 
1               5                   10                  15      


Leu Ala Ile Leu Leu Leu Leu Trp Glu Ala Gly Ser Glu Ala Val Arg 
            20                  25                  30          


Tyr Ser Ile Pro Glu Glu Thr Glu Ser Gly Tyr Ser Val Ala Asn Leu 
        35                  40                  45              


Ala Lys Asp Leu Gly Leu Gly Val Gly Glu Leu Ala Thr Arg Gly Ala 
    50                  55                  60                  


Arg Met His Tyr Lys Gly Asn Lys Glu Leu Leu Gln Leu Asp Ile Lys 
65                  70                  75                  80  


Thr Gly Asn Leu Leu Leu Tyr Glu Lys Leu Asp Arg Glu Val Met Cys 
                85                  90                  95      


Gly Ala Thr Glu Pro Cys Ile Leu His Phe Gln Leu Leu Leu Glu Asn 
            100                 105                 110         


Pro Val Gln Phe Phe Gln Thr Asp Leu Gln Leu Thr Asp Ile Asn Asp 
        115                 120                 125             


His Ala Pro Glu Phe Pro Glu Lys Glu Met Leu Leu Lys Ile Pro Glu 
    130                 135                 140                 


Ser Thr Gln Pro Gly Thr Val Phe Pro Leu Lys Ile Ala Gln Asp Phe 
145                 150                 155                 160 


Asp Ile Gly Ser Asn Thr Val Gln Asn Tyr Thr Ile Ser Pro Asn Ser 
                165                 170                 175     


His Phe His Val Ala Thr His Asn Arg Gly Asp Gly Arg Lys Tyr Pro 
            180                 185                 190         


Glu Leu Val Leu Asp Lys Ala Leu Asp Arg Glu Glu Arg Pro Glu Leu 
        195                 200                 205             


Ser Leu Thr Leu Thr Ala Leu Asp Gly Gly Ala Pro Pro Arg Ser Gly 
    210                 215                 220                 


Thr Thr Thr Ile Arg Ile Val Val Leu Asp Asn Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Glu Phe Leu Gln Ser Phe Tyr Glu Val Gln Val Pro Glu Asn Ser Pro 
                245                 250                 255     


Leu Asn Ser Leu Val Val Val Val Ser Ala Arg Asp Leu Asp Ala Gly 
            260                 265                 270         


Ala Tyr Gly Ser Val Ala Tyr Ala Leu Phe Gln Gly Asp Glu Val Thr 
        275                 280                 285             


Gln Pro Phe Val Ile Asp Glu Lys Thr Ala Glu Ile Arg Leu Lys Arg 
    290                 295                 300                 


Ala Leu Asp Phe Glu Ala Thr Pro Tyr Tyr Asn Val Glu Ile Val Ala 
305                 310                 315                 320 


Thr Asp Gly Gly Gly Leu Ser Gly Lys Cys Thr Val Ala Ile Glu Val 
                325                 330                 335     


Val Asp Val Asn Asp Asn Ala Pro Glu Leu Thr Met Ser Thr Leu Ser 
            340                 345                 350         


Ser Pro Thr Pro Glu Asn Ala Pro Glu Thr Val Val Ala Val Phe Ser 
        355                 360                 365             


Val Ser Asp Pro Asp Ser Gly Asp Asn Gly Arg Met Ile Cys Ser Ile 
    370                 375                 380                 


Gln Asn Asp Leu Pro Phe Leu Leu Lys Pro Thr Leu Lys Asn Phe Tyr 
385                 390                 395                 400 


Thr Leu Val Thr Gln Arg Thr Leu Asp Arg Glu Ser Gln Ala Glu Tyr 
                405                 410                 415     


Asn Ile Thr Ile Thr Val Thr Asp Met Gly Thr Pro Arg Leu Lys Thr 
            420                 425                 430         


Glu His Asn Ile Thr Val Leu Val Ser Asp Val Asn Asp Asn Ala Pro 
        435                 440                 445             


Ala Phe Thr Gln Thr Ser Tyr Thr Leu Phe Val Arg Glu Asn Asn Ser 
    450                 455                 460                 


Pro Ala Leu His Ile Gly Ser Val Ser Ala Thr Asp Arg Asp Ser Gly 
465                 470                 475                 480 


Thr Asn Ala Gln Val Thr Tyr Ser Leu Leu Pro Pro Gln Asn Pro His 
                485                 490                 495     


Leu Arg Leu Ala Ser Leu Val Ser Ile Asn Ala Asp Asn Gly His Leu 
            500                 505                 510         


Phe Ala Leu Arg Ser Leu Asp Tyr Glu Ala Leu Gln Ala Phe Glu Phe 
        515                 520                 525             


Arg Val Gly Ala Thr Asp Arg Gly Ser Pro Ala Leu Ser Ser Glu Ala 
    530                 535                 540                 


Leu Val Arg Val Leu Val Leu Asp Ala Asn Asp Asn Ser Pro Phe Val 
545                 550                 555                 560 


Leu Tyr Pro Leu Gln Asn Gly Ser Ala Pro Cys Thr Glu Leu Val Pro 
                565                 570                 575     


Arg Ala Ala Glu Pro Gly Tyr Leu Val Thr Lys Val Val Ala Val Asp 
            580                 585                 590         


Gly Asp Ser Gly Gln Asn Ala Trp Leu Ser Tyr Gln Leu Leu Lys Ala 
        595                 600                 605             


Thr Glu Pro Gly Leu Phe Ser Met Trp Ala His Asn Gly Glu Val Arg 
    610                 615                 620                 


Thr Ala Arg Leu Leu Ser Glu Arg Asp Ala Ala Lys His Arg Leu Val 
625                 630                 635                 640 


Val Leu Val Lys Asp Asn Gly Glu Pro Pro Arg Ser Ala Thr Ala Thr 
                645                 650                 655     


Leu His Val Leu Leu Val Asp Gly Phe Ser Gln Pro Tyr Leu Pro Leu 
            660                 665                 670         


Pro Glu Ala Ala Pro Ala Gln Ala Gln Ala Asp Ser Leu Thr Val Tyr 
        675                 680                 685             


Leu Val Val Ala Leu Ala Ser Val Ser Ser Leu Phe Leu Phe Ser Val 
    690                 695                 700                 


Leu Leu Phe Val Ala Val Arg Leu Cys Arg Arg Ser Arg Ala Ala Ser 
705                 710                 715                 720 


Val Gly Arg Cys Ser Val Pro Glu Gly Pro Phe Pro Gly His Leu Val 
                725                 730                 735     


Asp Val Ser Gly Thr Gly Thr Leu Ser Gln Ser Tyr His Tyr Glu Val 
            740                 745                 750         


Cys Leu Thr Gly Asp Ser Gly Ala Gly Glu Phe Lys Phe Leu Lys Pro 
        755                 760                 765             


Ile Ile Pro Asn Leu Leu Pro Gln Gly Ala Gly Glu Glu Ile Gly Lys 
    770                 775                 780                 


Thr Ala Ala Phe Arg Asn Ser Phe Gly Leu Asn 
785                 790                 795 

<210>  283
<211>  6784
<212>  DNA
<213>  Homo sapiens

<400>  283
ggcgccgcct ccacccgctc cccgctcggt cccgctcgct cgcccaggcc gggctgccct     60

ttcgcgtgtc cgcgctctct tccctccgcc gccgcctcct ccattttgcg agctcgtgtc    120

tgtgacggga gcccgagtca ccgcctgccc gtcggggacg gattctgtgg gtggaaggag    180

acgccgcagc cggagcggcc gaagcagctg ggaccgggac ggggcacgcg cgcccggaac    240

ctcgacccgc ggagcccggc gcggggcgga gggctggctt gtcagctggg caatgggaga    300

ctttcttaaa taggggctct ccccccaccc atggagaaag gggcggctgt ttacttcctt    360

tttttagaaa aaaaaaatat atttccctcc tgctccttct gcgttcacaa gctaagttgt    420

ttatctcggc tgcggcggga actgcggacg gtggcgggcg agcggctcct ctgccagagt    480

tgatattcac tgatggactc caaagaatca ttaactcctg gtagagaaga aaaccccagc    540

agtgtgcttg ctcaggagag gggagatgtg atggacttct ataaaaccct aagaggagga    600

gctactgtga aggtttctgc gtcttcaccc tcactggctg tcgcttctca atcagactcc    660

aagcagcgaa gacttttggt tgattttcca aaaggctcag taagcaatgc gcagcagcca    720

gatctgtcca aagcagtttc actctcaatg ggactgtata tgggagagac agaaacaaaa    780

gtgatgggaa atgacctggg attcccacag cagggccaaa tcagcctttc ctcgggggaa    840

acagacttaa agcttttgga agaaagcatt gcaaacctca ataggtcgac cagtgttcca    900

gagaacccca agagttcagc atccactgct gtgtctgctg cccccacaga gaaggagttt    960

ccaaaaactc actctgatgt atcttcagaa cagcaacatt tgaagggcca gactggcacc   1020

aacggtggca atgtgaaatt gtataccaca gaccaaagca cctttgacat tttgcaggat   1080

ttggagtttt cttctgggtc cccaggtaaa gagacgaatg agagtccttg gagatcagac   1140

ctgttgatag atgaaaactg tttgctttct cctctggcgg gagaagacga ttcattcctt   1200

ttggaaggaa actcgaatga ggactgcaag cctctcattt taccggacac taaacccaaa   1260

attaaggata atggagatct ggttttgtca agccccagta atgtaacact gccccaagtg   1320

aaaacagaaa aagaagattt catcgaactc tgcacccctg gggtaattaa gcaagagaaa   1380

ctgggcacag tttactgtca ggcaagcttt cctggagcaa atataattgg taataaaatg   1440

tctgccattt ctgttcatgg tgtgagtacc tctggaggac agatgtacca ctatgacatg   1500

aatacagcat ccctttctca acagcaggat cagaagccta tttttaatgt cattccacca   1560

attcccgttg gttccgaaaa ttggaatagg tgccaaggat ctggagatga caacttgact   1620

tctctgggga ctctgaactt ccctggtcga acagtttttt ctaatggcta ttcaagcccc   1680

agcatgagac cagatgtaag ctctcctcca tccagctcct caacagcaac aacaggacca   1740

cctcccaaac tctgcctggt gtgctctgat gaagcttcag gatgtcatta tggagtctta   1800

acttgtggaa gctgtaaagt tttcttcaaa agagcagtgg aaggacagca caattaccta   1860

tgtgctggaa ggaatgattg catcatcgat aaaattcgaa gaaaaaactg cccagcatgc   1920

cgctatcgaa aatgtcttca ggctggaatg aacctggaag ctcgaaaaac aaagaaaaaa   1980

ataaaaggaa ttcagcaggc cactacagga gtctcacaag aaacctctga aaatcctggt   2040

aacaaaacaa tagttcctgc aacgttacca caactcaccc ctaccctggt gtcactgttg   2100

gaggttattg aacctgaagt gttatatgca ggatatgata gctctgttcc agactcaact   2160

tggaggatca tgactacgct caacatgtta ggagggcggc aagtgattgc agcagtgaaa   2220

tgggcaaagg caataccagg tttcaggaac ttacacctgg atgaccaaat gaccctactg   2280

cagtactcct ggatgtttct tatggcattt gctctggggt ggagatcata tagacaatca   2340

agtgcaaacc tgctgtgttt tgctcctgat ctgattatta atgagcagag aatgactcta   2400

ccctgcatgt acgaccaatg taaacacatg ctgtatgttt cctctgagtt acacaggctt   2460

caggtatctt atgaagagta tctctgtatg aaaaccttac tgcttctctc ttcagttcct   2520

aaggacggtc tgaagagcca agagctattt gatgaaatta gaatgaccta catcaaagag   2580

ctaggaaaag ccattgtcaa gagggaagga aactccagcc agaactggca gcggttttat   2640

caactgacaa aactcttgga ttctatgcat gaagtggttg aaaatctcct taactattgc   2700

ttccaaacat ttttggataa gaccatgagt attgaattcc ccgagatgtt agctgaaatc   2760

atcaccaatc agataccaaa atattcaaat ggaaatatca aaaaacttct gtttcatcaa   2820

aagtgactgc cttaataaga atggttgcct taaagaaagt cgaattaata gcttttattg   2880

tataaactat cagtttgtcc tgtagaggtt ttgttgtttt attttttatt gttttcatct   2940

gttgttttgt tttaaatacg cactacatgt ggtttataga gggccaagac ttggcaacag   3000

aagcagttga gtcgtcatca cttttcagtg atgggagagt agatggtgaa atttattagt   3060

taatatatcc cagaaattag aaaccttaat atgtggacgt aatctccaca gtcaaagaag   3120

gatggcacct aaaccaccag tgcccaaagt ctgtgtgatg aactttctct tcatactttt   3180

tttcacagtt ggctggatga aattttctag actttctgtt ggtgtatccc ccccctgtat   3240

agttaggata gcatttttga tttatgcatg gaaacctgaa aaaaagttta caagtgtata   3300

tcagaaaagg gaagttgtgc cttttatagc tattactgtc tggttttaac aatttccttt   3360

atatttagtg aactacgctt gctcattttt tcttacataa ttttttattc aagttattgt   3420

acagctgttt aagatgggca gctagttcgt agctttccca aataaactct aaacattaat   3480

caatcatctg tgtgaaaatg ggttggtgct tctaacctga tggcacttag ctatcagaag   3540

accacaaaaa ttgactcaaa tctccagtat tcttgtcaaa aaaaaaaaaa aaaaagctca   3600

tattttgtat atatctgctt cagtggagaa ttatataggt tgtgcaaatt aacagtccta   3660

actggtatag agcacctagt ccagtgacct gctgggtaaa ctgtggatga tggttgcaaa   3720

agactaattt aaaaaataac taccaagagg ccctgtctgt acctaacgcc ctatttttgc   3780

aatggctata tggcaagaaa gctggtaaac tatttgtctt tcaggacctt ttgaagtagt   3840

ttgtataact tcttaaaagt tgtgattcca gataaccagc tgtaacacag ctgagagact   3900

tttaatcaga caaagtaatt cctctcacta aactttaccc aaaaactaaa tctctaatat   3960

ggcaaaaatg gctagacacc cattttcaca ttcccatctg tcaccaattg gttaatcttt   4020

cctgatggta caggaaagct cagctactga tttttgtgat ttagaactgt atgtcagaca   4080

tccatgtttg taaaactaca catccctaat gtgtgccata gagtttaaca caagtcctgt   4140

gaatttcttc actgttgaaa attattttaa acaaaataga agctgtagta gccctttctg   4200

tgtgcacctt accaactttc tgtaaactca aaacttaaca tatttactaa gccacaagaa   4260

atttgatttc tattcaaggt ggccaaatta tttgtgtaat agaaaactga aaatctaata   4320

ttaaaaatat ggaacttcta atatattttt atatttagtt atagtttcag atatatatca   4380

tattggtatt cactaatctg ggaagggaag ggctactgca gctttacatg caatttatta   4440

aaatgattgt aaaatagctt gtatagtgta aaataagaat gatttttaga tgagattgtt   4500

ttatcatgac atgttatata ttttttgtag gggtcaaaga aatgctgatg gataacctat   4560

atgatttata gtttgtacat gcattcatac aggcagcgat ggtctcagaa accaaacagt   4620

ttgctctagg ggaagaggga gatggagact ggtcctgtgt gcagtgaagg ttgctgaggc   4680

tctgacccag tgagattaca gaggaagtta tcctctgcct cccattctga ccacccttct   4740

cattccaaca gtgagtctgt cagcgcaggt ttagtttact caatctcccc ttgcactaaa   4800

gtatgtaaag tatgtaaaca ggagacagga aggtggtgct tacatcctta aaggcaccat   4860

ctaatagcgg gttactttca catacagccc tcccccagca gttgaatgac aacagaagct   4920

tcagaagttt ggcaatagtt tgcatagagg taccagcaat atgtaaatag tgcagaatct   4980

cataggttgc caataataca ctaattcctt tctatcctac aacaagagtt tatttccaaa   5040

taaaatgagg acatgttttt gttttctttg aatgcttttt gaatgttatt tgttattttc   5100

agtattttgg agaaattatt taataaaaaa acaatcattt gctttttgaa tgctctctaa   5160

aagggaatgt aatattttaa gatggtgtgt aacccggctg gataaatttt tggtgcctaa   5220

gaaaactgct tgaatattct tatcaatgac agtgttaagt ttcaaaaaga gcttctaaaa   5280

cgtagattat cattccttta tagaatgtta tgtggttaaa accagaaagc acatctcaca   5340

cattaatctg attttcatcc caacaatctt ggcgctcaaa aaatagaact caatgagaaa   5400

aagaagatta tgtgcacttc gttgtcaata ataagtcaac tgatgctcat cgacaactat   5460

aggaggcttt tcattaaatg ggaaaagaag ctgtgccctt ttaggatacg tgggggaaaa   5520

gaaagtcatc ttaattatgt ttaattgtgg atttaagtgc tatatggtgg tgctgtttga   5580

aagcagattt atttcctatg tatgtgttat ctggccatcc caacccaaac tgttgaagtt   5640

tgtagtaact tcagtgagag ttggttactc acaacaaatc ctgaaaagta tttttagtgt   5700

ttgtaggtat tctgtgggat actatacaag cagaactgag gcacttagga cataacactt   5760

ttggggtata tatatccaaa tgcctaaaac tatgggagga aaccttggcc accccaaaag   5820

gaaaactaac atgatttgtg tctatgaagt gctggataat tagcatggga tgagctctgg   5880

gcatgccatg aaggaaagcc acgctccctt cagaattcag aggcagggag caattccagt   5940

ttcacctaag tctcataatt ttagttccct tttaaaaacc ctgaaaacta catcaccatg   6000

gaatgaaaaa tattgttata caatacattg atctgtcaaa cttccagaac catggtagcc   6060

ttcagtgaga tttccatctt ggctggtcac tccctgactg tagctgtagg tgaatgtgtt   6120

tttgtgtgtg tgtgtctggt tttagtgtca gaagggaaat aaaagtgtaa ggaggacact   6180

ttaaaccctt tgggtggagt ttcgtaattt cccagactat tttcaagcaa cctggtccac   6240

ccaggattag tgaccaggtt ttcaggaaag gatttgcttc tctctagaaa atgtctgaaa   6300

ggattttatt ttctgatgaa aggctgtatg aaaataccct cctcaaataa cttgcttaac   6360

tacatataga ttcaagtgtg tcaatattct attttgtata ttaaatgcta tataatgggg   6420

acaaatctat attatactgt gtatggcatt attaagaagc tttttcatta ttttttatca   6480

cagtaatttt aaaatgtgta aaaattaaaa ccagtgactc ctgtttaaaa ataaaagttg   6540

tagtttttta ttcatgctga ataataatct gtagttaaaa aaaaagtgtc tttttaccta   6600

cgcagtgaaa tgtcagactg taaaaccttg tgtggaaatg tttaactttt attttttcat   6660

ttaaatttgc tgttctggta ttaccaaacc acacatttgt accgaattgg cagtaaatgt   6720

tagccattta cagcaatgcc aaatatggag aaacatcata ataaaaaaat ctgctttttc   6780

atta                                                                6784


<210>  284
<211>  777
<212>  PRT
<213>  Homo sapiens

<400>  284


Met Asp Ser Lys Glu Ser Leu Thr Pro Gly Arg Glu Glu Asn Pro Ser 
1               5                   10                  15      


Ser Val Leu Ala Gln Glu Arg Gly Asp Val Met Asp Phe Tyr Lys Thr 
            20                  25                  30          


Leu Arg Gly Gly Ala Thr Val Lys Val Ser Ala Ser Ser Pro Ser Leu 
        35                  40                  45              


Ala Val Ala Ser Gln Ser Asp Ser Lys Gln Arg Arg Leu Leu Val Asp 
    50                  55                  60                  


Phe Pro Lys Gly Ser Val Ser Asn Ala Gln Gln Pro Asp Leu Ser Lys 
65                  70                  75                  80  


Ala Val Ser Leu Ser Met Gly Leu Tyr Met Gly Glu Thr Glu Thr Lys 
                85                  90                  95      


Val Met Gly Asn Asp Leu Gly Phe Pro Gln Gln Gly Gln Ile Ser Leu 
            100                 105                 110         


Ser Ser Gly Glu Thr Asp Leu Lys Leu Leu Glu Glu Ser Ile Ala Asn 
        115                 120                 125             


Leu Asn Arg Ser Thr Ser Val Pro Glu Asn Pro Lys Ser Ser Ala Ser 
    130                 135                 140                 


Thr Ala Val Ser Ala Ala Pro Thr Glu Lys Glu Phe Pro Lys Thr His 
145                 150                 155                 160 


Ser Asp Val Ser Ser Glu Gln Gln His Leu Lys Gly Gln Thr Gly Thr 
                165                 170                 175     


Asn Gly Gly Asn Val Lys Leu Tyr Thr Thr Asp Gln Ser Thr Phe Asp 
            180                 185                 190         


Ile Leu Gln Asp Leu Glu Phe Ser Ser Gly Ser Pro Gly Lys Glu Thr 
        195                 200                 205             


Asn Glu Ser Pro Trp Arg Ser Asp Leu Leu Ile Asp Glu Asn Cys Leu 
    210                 215                 220                 


Leu Ser Pro Leu Ala Gly Glu Asp Asp Ser Phe Leu Leu Glu Gly Asn 
225                 230                 235                 240 


Ser Asn Glu Asp Cys Lys Pro Leu Ile Leu Pro Asp Thr Lys Pro Lys 
                245                 250                 255     


Ile Lys Asp Asn Gly Asp Leu Val Leu Ser Ser Pro Ser Asn Val Thr 
            260                 265                 270         


Leu Pro Gln Val Lys Thr Glu Lys Glu Asp Phe Ile Glu Leu Cys Thr 
        275                 280                 285             


Pro Gly Val Ile Lys Gln Glu Lys Leu Gly Thr Val Tyr Cys Gln Ala 
    290                 295                 300                 


Ser Phe Pro Gly Ala Asn Ile Ile Gly Asn Lys Met Ser Ala Ile Ser 
305                 310                 315                 320 


Val His Gly Val Ser Thr Ser Gly Gly Gln Met Tyr His Tyr Asp Met 
                325                 330                 335     


Asn Thr Ala Ser Leu Ser Gln Gln Gln Asp Gln Lys Pro Ile Phe Asn 
            340                 345                 350         


Val Ile Pro Pro Ile Pro Val Gly Ser Glu Asn Trp Asn Arg Cys Gln 
        355                 360                 365             


Gly Ser Gly Asp Asp Asn Leu Thr Ser Leu Gly Thr Leu Asn Phe Pro 
    370                 375                 380                 


Gly Arg Thr Val Phe Ser Asn Gly Tyr Ser Ser Pro Ser Met Arg Pro 
385                 390                 395                 400 


Asp Val Ser Ser Pro Pro Ser Ser Ser Ser Thr Ala Thr Thr Gly Pro 
                405                 410                 415     


Pro Pro Lys Leu Cys Leu Val Cys Ser Asp Glu Ala Ser Gly Cys His 
            420                 425                 430         


Tyr Gly Val Leu Thr Cys Gly Ser Cys Lys Val Phe Phe Lys Arg Ala 
        435                 440                 445             


Val Glu Gly Gln His Asn Tyr Leu Cys Ala Gly Arg Asn Asp Cys Ile 
    450                 455                 460                 


Ile Asp Lys Ile Arg Arg Lys Asn Cys Pro Ala Cys Arg Tyr Arg Lys 
465                 470                 475                 480 


Cys Leu Gln Ala Gly Met Asn Leu Glu Ala Arg Lys Thr Lys Lys Lys 
                485                 490                 495     


Ile Lys Gly Ile Gln Gln Ala Thr Thr Gly Val Ser Gln Glu Thr Ser 
            500                 505                 510         


Glu Asn Pro Gly Asn Lys Thr Ile Val Pro Ala Thr Leu Pro Gln Leu 
        515                 520                 525             


Thr Pro Thr Leu Val Ser Leu Leu Glu Val Ile Glu Pro Glu Val Leu 
    530                 535                 540                 


Tyr Ala Gly Tyr Asp Ser Ser Val Pro Asp Ser Thr Trp Arg Ile Met 
545                 550                 555                 560 


Thr Thr Leu Asn Met Leu Gly Gly Arg Gln Val Ile Ala Ala Val Lys 
                565                 570                 575     


Trp Ala Lys Ala Ile Pro Gly Phe Arg Asn Leu His Leu Asp Asp Gln 
            580                 585                 590         


Met Thr Leu Leu Gln Tyr Ser Trp Met Phe Leu Met Ala Phe Ala Leu 
        595                 600                 605             


Gly Trp Arg Ser Tyr Arg Gln Ser Ser Ala Asn Leu Leu Cys Phe Ala 
    610                 615                 620                 


Pro Asp Leu Ile Ile Asn Glu Gln Arg Met Thr Leu Pro Cys Met Tyr 
625                 630                 635                 640 


Asp Gln Cys Lys His Met Leu Tyr Val Ser Ser Glu Leu His Arg Leu 
                645                 650                 655     


Gln Val Ser Tyr Glu Glu Tyr Leu Cys Met Lys Thr Leu Leu Leu Leu 
            660                 665                 670         


Ser Ser Val Pro Lys Asp Gly Leu Lys Ser Gln Glu Leu Phe Asp Glu 
        675                 680                 685             


Ile Arg Met Thr Tyr Ile Lys Glu Leu Gly Lys Ala Ile Val Lys Arg 
    690                 695                 700                 


Glu Gly Asn Ser Ser Gln Asn Trp Gln Arg Phe Tyr Gln Leu Thr Lys 
705                 710                 715                 720 


Leu Leu Asp Ser Met His Glu Val Val Glu Asn Leu Leu Asn Tyr Cys 
                725                 730                 735     


Phe Gln Thr Phe Leu Asp Lys Thr Met Ser Ile Glu Phe Pro Glu Met 
            740                 745                 750         


Leu Ala Glu Ile Ile Thr Asn Gln Ile Pro Lys Tyr Ser Asn Gly Asn 
        755                 760                 765             


Ile Lys Lys Leu Leu Phe His Gln Lys 
    770                 775         

<210>  285
<211>  6614
<212>  DNA
<213>  Homo sapiens

<400>  285
aggttatgta agggtttgct ttcaccccat tcaaaaggta cctcttcctc ttctcttgct     60

ccctctcgcc ctcattcttg tgcctatgca gacatttgag tagaggcgaa tcactttcac    120

ttctgctggg gaaattgcaa cacgcttctt taaatggcag agagaaggag aaaacttaga    180

tcttctgata ccaaatcact ggaccttaga aggtcagaaa tctttcaagc cctgcaggac    240

cgtaaaatgc gcatgtgtcc aacggaagca ctggggcatg agtggggaag gaatagaaac    300

agaaagaggt tgatattcac tgatggactc caaagaatca ttaactcctg gtagagaaga    360

aaaccccagc agtgtgcttg ctcaggagag gggagatgtg atggacttct ataaaaccct    420

aagaggagga gctactgtga aggtttctgc gtcttcaccc tcactggctg tcgcttctca    480

atcagactcc aagcagcgaa gacttttggt tgattttcca aaaggctcag taagcaatgc    540

gcagcagcca gatctgtcca aagcagtttc actctcaatg ggactgtata tgggagagac    600

agaaacaaaa gtgatgggaa atgacctggg attcccacag cagggccaaa tcagcctttc    660

ctcgggggaa acagacttaa agcttttgga agaaagcatt gcaaacctca ataggtcgac    720

cagtgttcca gagaacccca agagttcagc atccactgct gtgtctgctg cccccacaga    780

gaaggagttt ccaaaaactc actctgatgt atcttcagaa cagcaacatt tgaagggcca    840

gactggcacc aacggtggca atgtgaaatt gtataccaca gaccaaagca cctttgacat    900

tttgcaggat ttggagtttt cttctgggtc cccaggtaaa gagacgaatg agagtccttg    960

gagatcagac ctgttgatag atgaaaactg tttgctttct cctctggcgg gagaagacga   1020

ttcattcctt ttggaaggaa actcgaatga ggactgcaag cctctcattt taccggacac   1080

taaacccaaa attaaggata atggagatct ggttttgtca agccccagta atgtaacact   1140

gccccaagtg aaaacagaaa aagaagattt catcgaactc tgcacccctg gggtaattaa   1200

gcaagagaaa ctgggcacag tttactgtca ggcaagcttt cctggagcaa atataattgg   1260

taataaaatg tctgccattt ctgttcatgg tgtgagtacc tctggaggac agatgtacca   1320

ctatgacatg aatacagcat ccctttctca acagcaggat cagaagccta tttttaatgt   1380

cattccacca attcccgttg gttccgaaaa ttggaatagg tgccaaggat ctggagatga   1440

caacttgact tctctgggga ctctgaactt ccctggtcga acagtttttt ctaatggcta   1500

ttcaagcccc agcatgagac cagatgtaag ctctcctcca tccagctcct caacagcaac   1560

aacaggacca cctcccaaac tctgcctggt gtgctctgat gaagcttcag gatgtcatta   1620

tggagtctta acttgtggaa gctgtaaagt tttcttcaaa agagcagtgg aaggacagca   1680

caattaccta tgtgctggaa ggaatgattg catcatcgat aaaattcgaa gaaaaaactg   1740

cccagcatgc cgctatcgaa aatgtcttca ggctggaatg aacctggaag ctcgaaaaac   1800

aaagaaaaaa ataaaaggaa ttcagcaggc cactacagga gtctcacaag aaacctctga   1860

aaatcctggt aacaaaacaa tagttcctgc aacgttacca caactcaccc ctaccctggt   1920

gtcactgttg gaggttattg aacctgaagt gttatatgca ggatatgata gctctgttcc   1980

agactcaact tggaggatca tgactacgct caacatgtta ggagggcggc aagtgattgc   2040

agcagtgaaa tgggcaaagg caataccagg tttcaggaac ttacacctgg atgaccaaat   2100

gaccctactg cagtactcct ggatgtttct tatggcattt gctctggggt ggagatcata   2160

tagacaatca agtgcaaacc tgctgtgttt tgctcctgat ctgattatta atgagcagag   2220

aatgactcta ccctgcatgt acgaccaatg taaacacatg ctgtatgttt cctctgagtt   2280

acacaggctt caggtatctt atgaagagta tctctgtatg aaaaccttac tgcttctctc   2340

ttcagttcct aaggacggtc tgaagagcca agagctattt gatgaaatta gaatgaccta   2400

catcaaagag ctaggaaaag ccattgtcaa gagggaagga aactccagcc agaactggca   2460

gcggttttat caactgacaa aactcttgga ttctatgcat gaagtggttg aaaatctcct   2520

taactattgc ttccaaacat ttttggataa gaccatgagt attgaattcc ccgagatgtt   2580

agctgaaatc atcaccaatc agataccaaa atattcaaat ggaaatatca aaaaacttct   2640

gtttcatcaa aagtgactgc cttaataaga atggttgcct taaagaaagt cgaattaata   2700

gcttttattg tataaactat cagtttgtcc tgtagaggtt ttgttgtttt attttttatt   2760

gttttcatct gttgttttgt tttaaatacg cactacatgt ggtttataga gggccaagac   2820

ttggcaacag aagcagttga gtcgtcatca cttttcagtg atgggagagt agatggtgaa   2880

atttattagt taatatatcc cagaaattag aaaccttaat atgtggacgt aatctccaca   2940

gtcaaagaag gatggcacct aaaccaccag tgcccaaagt ctgtgtgatg aactttctct   3000

tcatactttt tttcacagtt ggctggatga aattttctag actttctgtt ggtgtatccc   3060

ccccctgtat agttaggata gcatttttga tttatgcatg gaaacctgaa aaaaagttta   3120

caagtgtata tcagaaaagg gaagttgtgc cttttatagc tattactgtc tggttttaac   3180

aatttccttt atatttagtg aactacgctt gctcattttt tcttacataa ttttttattc   3240

aagttattgt acagctgttt aagatgggca gctagttcgt agctttccca aataaactct   3300

aaacattaat caatcatctg tgtgaaaatg ggttggtgct tctaacctga tggcacttag   3360

ctatcagaag accacaaaaa ttgactcaaa tctccagtat tcttgtcaaa aaaaaaaaaa   3420

aaaaagctca tattttgtat atatctgctt cagtggagaa ttatataggt tgtgcaaatt   3480

aacagtccta actggtatag agcacctagt ccagtgacct gctgggtaaa ctgtggatga   3540

tggttgcaaa agactaattt aaaaaataac taccaagagg ccctgtctgt acctaacgcc   3600

ctatttttgc aatggctata tggcaagaaa gctggtaaac tatttgtctt tcaggacctt   3660

ttgaagtagt ttgtataact tcttaaaagt tgtgattcca gataaccagc tgtaacacag   3720

ctgagagact tttaatcaga caaagtaatt cctctcacta aactttaccc aaaaactaaa   3780

tctctaatat ggcaaaaatg gctagacacc cattttcaca ttcccatctg tcaccaattg   3840

gttaatcttt cctgatggta caggaaagct cagctactga tttttgtgat ttagaactgt   3900

atgtcagaca tccatgtttg taaaactaca catccctaat gtgtgccata gagtttaaca   3960

caagtcctgt gaatttcttc actgttgaaa attattttaa acaaaataga agctgtagta   4020

gccctttctg tgtgcacctt accaactttc tgtaaactca aaacttaaca tatttactaa   4080

gccacaagaa atttgatttc tattcaaggt ggccaaatta tttgtgtaat agaaaactga   4140

aaatctaata ttaaaaatat ggaacttcta atatattttt atatttagtt atagtttcag   4200

atatatatca tattggtatt cactaatctg ggaagggaag ggctactgca gctttacatg   4260

caatttatta aaatgattgt aaaatagctt gtatagtgta aaataagaat gatttttaga   4320

tgagattgtt ttatcatgac atgttatata ttttttgtag gggtcaaaga aatgctgatg   4380

gataacctat atgatttata gtttgtacat gcattcatac aggcagcgat ggtctcagaa   4440

accaaacagt ttgctctagg ggaagaggga gatggagact ggtcctgtgt gcagtgaagg   4500

ttgctgaggc tctgacccag tgagattaca gaggaagtta tcctctgcct cccattctga   4560

ccacccttct cattccaaca gtgagtctgt cagcgcaggt ttagtttact caatctcccc   4620

ttgcactaaa gtatgtaaag tatgtaaaca ggagacagga aggtggtgct tacatcctta   4680

aaggcaccat ctaatagcgg gttactttca catacagccc tcccccagca gttgaatgac   4740

aacagaagct tcagaagttt ggcaatagtt tgcatagagg taccagcaat atgtaaatag   4800

tgcagaatct cataggttgc caataataca ctaattcctt tctatcctac aacaagagtt   4860

tatttccaaa taaaatgagg acatgttttt gttttctttg aatgcttttt gaatgttatt   4920

tgttattttc agtattttgg agaaattatt taataaaaaa acaatcattt gctttttgaa   4980

tgctctctaa aagggaatgt aatattttaa gatggtgtgt aacccggctg gataaatttt   5040

tggtgcctaa gaaaactgct tgaatattct tatcaatgac agtgttaagt ttcaaaaaga   5100

gcttctaaaa cgtagattat cattccttta tagaatgtta tgtggttaaa accagaaagc   5160

acatctcaca cattaatctg attttcatcc caacaatctt ggcgctcaaa aaatagaact   5220

caatgagaaa aagaagatta tgtgcacttc gttgtcaata ataagtcaac tgatgctcat   5280

cgacaactat aggaggcttt tcattaaatg ggaaaagaag ctgtgccctt ttaggatacg   5340

tgggggaaaa gaaagtcatc ttaattatgt ttaattgtgg atttaagtgc tatatggtgg   5400

tgctgtttga aagcagattt atttcctatg tatgtgttat ctggccatcc caacccaaac   5460

tgttgaagtt tgtagtaact tcagtgagag ttggttactc acaacaaatc ctgaaaagta   5520

tttttagtgt ttgtaggtat tctgtgggat actatacaag cagaactgag gcacttagga   5580

cataacactt ttggggtata tatatccaaa tgcctaaaac tatgggagga aaccttggcc   5640

accccaaaag gaaaactaac atgatttgtg tctatgaagt gctggataat tagcatggga   5700

tgagctctgg gcatgccatg aaggaaagcc acgctccctt cagaattcag aggcagggag   5760

caattccagt ttcacctaag tctcataatt ttagttccct tttaaaaacc ctgaaaacta   5820

catcaccatg gaatgaaaaa tattgttata caatacattg atctgtcaaa cttccagaac   5880

catggtagcc ttcagtgaga tttccatctt ggctggtcac tccctgactg tagctgtagg   5940

tgaatgtgtt tttgtgtgtg tgtgtctggt tttagtgtca gaagggaaat aaaagtgtaa   6000

ggaggacact ttaaaccctt tgggtggagt ttcgtaattt cccagactat tttcaagcaa   6060

cctggtccac ccaggattag tgaccaggtt ttcaggaaag gatttgcttc tctctagaaa   6120

atgtctgaaa ggattttatt ttctgatgaa aggctgtatg aaaataccct cctcaaataa   6180

cttgcttaac tacatataga ttcaagtgtg tcaatattct attttgtata ttaaatgcta   6240

tataatgggg acaaatctat attatactgt gtatggcatt attaagaagc tttttcatta   6300

ttttttatca cagtaatttt aaaatgtgta aaaattaaaa ccagtgactc ctgtttaaaa   6360

ataaaagttg tagtttttta ttcatgctga ataataatct gtagttaaaa aaaaagtgtc   6420

tttttaccta cgcagtgaaa tgtcagactg taaaaccttg tgtggaaatg tttaactttt   6480

attttttcat ttaaatttgc tgttctggta ttaccaaacc acacatttgt accgaattgg   6540

cagtaaatgt tagccattta cagcaatgcc aaatatggag aaacatcata ataaaaaaat   6600

ctgctttttc atta                                                     6614


<210>  286
<211>  777
<212>  PRT
<213>  Homo sapiens

<400>  286


Met Asp Ser Lys Glu Ser Leu Thr Pro Gly Arg Glu Glu Asn Pro Ser 
1               5                   10                  15      


Ser Val Leu Ala Gln Glu Arg Gly Asp Val Met Asp Phe Tyr Lys Thr 
            20                  25                  30          


Leu Arg Gly Gly Ala Thr Val Lys Val Ser Ala Ser Ser Pro Ser Leu 
        35                  40                  45              


Ala Val Ala Ser Gln Ser Asp Ser Lys Gln Arg Arg Leu Leu Val Asp 
    50                  55                  60                  


Phe Pro Lys Gly Ser Val Ser Asn Ala Gln Gln Pro Asp Leu Ser Lys 
65                  70                  75                  80  


Ala Val Ser Leu Ser Met Gly Leu Tyr Met Gly Glu Thr Glu Thr Lys 
                85                  90                  95      


Val Met Gly Asn Asp Leu Gly Phe Pro Gln Gln Gly Gln Ile Ser Leu 
            100                 105                 110         


Ser Ser Gly Glu Thr Asp Leu Lys Leu Leu Glu Glu Ser Ile Ala Asn 
        115                 120                 125             


Leu Asn Arg Ser Thr Ser Val Pro Glu Asn Pro Lys Ser Ser Ala Ser 
    130                 135                 140                 


Thr Ala Val Ser Ala Ala Pro Thr Glu Lys Glu Phe Pro Lys Thr His 
145                 150                 155                 160 


Ser Asp Val Ser Ser Glu Gln Gln His Leu Lys Gly Gln Thr Gly Thr 
                165                 170                 175     


Asn Gly Gly Asn Val Lys Leu Tyr Thr Thr Asp Gln Ser Thr Phe Asp 
            180                 185                 190         


Ile Leu Gln Asp Leu Glu Phe Ser Ser Gly Ser Pro Gly Lys Glu Thr 
        195                 200                 205             


Asn Glu Ser Pro Trp Arg Ser Asp Leu Leu Ile Asp Glu Asn Cys Leu 
    210                 215                 220                 


Leu Ser Pro Leu Ala Gly Glu Asp Asp Ser Phe Leu Leu Glu Gly Asn 
225                 230                 235                 240 


Ser Asn Glu Asp Cys Lys Pro Leu Ile Leu Pro Asp Thr Lys Pro Lys 
                245                 250                 255     


Ile Lys Asp Asn Gly Asp Leu Val Leu Ser Ser Pro Ser Asn Val Thr 
            260                 265                 270         


Leu Pro Gln Val Lys Thr Glu Lys Glu Asp Phe Ile Glu Leu Cys Thr 
        275                 280                 285             


Pro Gly Val Ile Lys Gln Glu Lys Leu Gly Thr Val Tyr Cys Gln Ala 
    290                 295                 300                 


Ser Phe Pro Gly Ala Asn Ile Ile Gly Asn Lys Met Ser Ala Ile Ser 
305                 310                 315                 320 


Val His Gly Val Ser Thr Ser Gly Gly Gln Met Tyr His Tyr Asp Met 
                325                 330                 335     


Asn Thr Ala Ser Leu Ser Gln Gln Gln Asp Gln Lys Pro Ile Phe Asn 
            340                 345                 350         


Val Ile Pro Pro Ile Pro Val Gly Ser Glu Asn Trp Asn Arg Cys Gln 
        355                 360                 365             


Gly Ser Gly Asp Asp Asn Leu Thr Ser Leu Gly Thr Leu Asn Phe Pro 
    370                 375                 380                 


Gly Arg Thr Val Phe Ser Asn Gly Tyr Ser Ser Pro Ser Met Arg Pro 
385                 390                 395                 400 


Asp Val Ser Ser Pro Pro Ser Ser Ser Ser Thr Ala Thr Thr Gly Pro 
                405                 410                 415     


Pro Pro Lys Leu Cys Leu Val Cys Ser Asp Glu Ala Ser Gly Cys His 
            420                 425                 430         


Tyr Gly Val Leu Thr Cys Gly Ser Cys Lys Val Phe Phe Lys Arg Ala 
        435                 440                 445             


Val Glu Gly Gln His Asn Tyr Leu Cys Ala Gly Arg Asn Asp Cys Ile 
    450                 455                 460                 


Ile Asp Lys Ile Arg Arg Lys Asn Cys Pro Ala Cys Arg Tyr Arg Lys 
465                 470                 475                 480 


Cys Leu Gln Ala Gly Met Asn Leu Glu Ala Arg Lys Thr Lys Lys Lys 
                485                 490                 495     


Ile Lys Gly Ile Gln Gln Ala Thr Thr Gly Val Ser Gln Glu Thr Ser 
            500                 505                 510         


Glu Asn Pro Gly Asn Lys Thr Ile Val Pro Ala Thr Leu Pro Gln Leu 
        515                 520                 525             


Thr Pro Thr Leu Val Ser Leu Leu Glu Val Ile Glu Pro Glu Val Leu 
    530                 535                 540                 


Tyr Ala Gly Tyr Asp Ser Ser Val Pro Asp Ser Thr Trp Arg Ile Met 
545                 550                 555                 560 


Thr Thr Leu Asn Met Leu Gly Gly Arg Gln Val Ile Ala Ala Val Lys 
                565                 570                 575     


Trp Ala Lys Ala Ile Pro Gly Phe Arg Asn Leu His Leu Asp Asp Gln 
            580                 585                 590         


Met Thr Leu Leu Gln Tyr Ser Trp Met Phe Leu Met Ala Phe Ala Leu 
        595                 600                 605             


Gly Trp Arg Ser Tyr Arg Gln Ser Ser Ala Asn Leu Leu Cys Phe Ala 
    610                 615                 620                 


Pro Asp Leu Ile Ile Asn Glu Gln Arg Met Thr Leu Pro Cys Met Tyr 
625                 630                 635                 640 


Asp Gln Cys Lys His Met Leu Tyr Val Ser Ser Glu Leu His Arg Leu 
                645                 650                 655     


Gln Val Ser Tyr Glu Glu Tyr Leu Cys Met Lys Thr Leu Leu Leu Leu 
            660                 665                 670         


Ser Ser Val Pro Lys Asp Gly Leu Lys Ser Gln Glu Leu Phe Asp Glu 
        675                 680                 685             


Ile Arg Met Thr Tyr Ile Lys Glu Leu Gly Lys Ala Ile Val Lys Arg 
    690                 695                 700                 


Glu Gly Asn Ser Ser Gln Asn Trp Gln Arg Phe Tyr Gln Leu Thr Lys 
705                 710                 715                 720 


Leu Leu Asp Ser Met His Glu Val Val Glu Asn Leu Leu Asn Tyr Cys 
                725                 730                 735     


Phe Gln Thr Phe Leu Asp Lys Thr Met Ser Ile Glu Phe Pro Glu Met 
            740                 745                 750         


Leu Ala Glu Ile Ile Thr Asn Gln Ile Pro Lys Tyr Ser Asn Gly Asn 
        755                 760                 765             


Ile Lys Lys Leu Leu Phe His Gln Lys 
    770                 775         

<210>  287
<211>  6517
<212>  DNA
<213>  Homo sapiens

<400>  287
aggttatgta agggtttgct ttcaccccat tcaaaaggta cctcttcctc ttctcttgct     60

ccctctcgcc ctcattcttg tgcctatgca gacatttgag tagaggcgaa tcactttcac    120

ttctgctggg gaaattgcaa cacgcttctt taaatggcag agagaaggag aaaacttaga    180

tcttctgata ccaaatcact ggaccttaga agttgatatt cactgatgga ctccaaagaa    240

tcattaactc ctggtagaga agaaaacccc agcagtgtgc ttgctcagga gaggggagat    300

gtgatggact tctataaaac cctaagagga ggagctactg tgaaggtttc tgcgtcttca    360

ccctcactgg ctgtcgcttc tcaatcagac tccaagcagc gaagactttt ggttgatttt    420

ccaaaaggct cagtaagcaa tgcgcagcag ccagatctgt ccaaagcagt ttcactctca    480

atgggactgt atatgggaga gacagaaaca aaagtgatgg gaaatgacct gggattccca    540

cagcagggcc aaatcagcct ttcctcgggg gaaacagact taaagctttt ggaagaaagc    600

attgcaaacc tcaataggtc gaccagtgtt ccagagaacc ccaagagttc agcatccact    660

gctgtgtctg ctgcccccac agagaaggag tttccaaaaa ctcactctga tgtatcttca    720

gaacagcaac atttgaaggg ccagactggc accaacggtg gcaatgtgaa attgtatacc    780

acagaccaaa gcacctttga cattttgcag gatttggagt tttcttctgg gtccccaggt    840

aaagagacga atgagagtcc ttggagatca gacctgttga tagatgaaaa ctgtttgctt    900

tctcctctgg cgggagaaga cgattcattc cttttggaag gaaactcgaa tgaggactgc    960

aagcctctca ttttaccgga cactaaaccc aaaattaagg ataatggaga tctggttttg   1020

tcaagcccca gtaatgtaac actgccccaa gtgaaaacag aaaaagaaga tttcatcgaa   1080

ctctgcaccc ctggggtaat taagcaagag aaactgggca cagtttactg tcaggcaagc   1140

tttcctggag caaatataat tggtaataaa atgtctgcca tttctgttca tggtgtgagt   1200

acctctggag gacagatgta ccactatgac atgaatacag catccctttc tcaacagcag   1260

gatcagaagc ctatttttaa tgtcattcca ccaattcccg ttggttccga aaattggaat   1320

aggtgccaag gatctggaga tgacaacttg acttctctgg ggactctgaa cttccctggt   1380

cgaacagttt tttctaatgg ctattcaagc cccagcatga gaccagatgt aagctctcct   1440

ccatccagct cctcaacagc aacaacagga ccacctccca aactctgcct ggtgtgctct   1500

gatgaagctt caggatgtca ttatggagtc ttaacttgtg gaagctgtaa agttttcttc   1560

aaaagagcag tggaaggaca gcacaattac ctatgtgctg gaaggaatga ttgcatcatc   1620

gataaaattc gaagaaaaaa ctgcccagca tgccgctatc gaaaatgtct tcaggctgga   1680

atgaacctgg aagctcgaaa aacaaagaaa aaaataaaag gaattcagca ggccactaca   1740

ggagtctcac aagaaacctc tgaaaatcct ggtaacaaaa caatagttcc tgcaacgtta   1800

ccacaactca cccctaccct ggtgtcactg ttggaggtta ttgaacctga agtgttatat   1860

gcaggatatg atagctctgt tccagactca acttggagga tcatgactac gctcaacatg   1920

ttaggagggc ggcaagtgat tgcagcagtg aaatgggcaa aggcaatacc aggtttcagg   1980

aacttacacc tggatgacca aatgacccta ctgcagtact cctggatgtt tcttatggca   2040

tttgctctgg ggtggagatc atatagacaa tcaagtgcaa acctgctgtg ttttgctcct   2100

gatctgatta ttaatgagca gagaatgact ctaccctgca tgtacgacca atgtaaacac   2160

atgctgtatg tttcctctga gttacacagg cttcaggtat cttatgaaga gtatctctgt   2220

atgaaaacct tactgcttct ctcttcagtt cctaaggacg gtctgaagag ccaagagcta   2280

tttgatgaaa ttagaatgac ctacatcaaa gagctaggaa aagccattgt caagagggaa   2340

ggaaactcca gccagaactg gcagcggttt tatcaactga caaaactctt ggattctatg   2400

catgaagtgg ttgaaaatct ccttaactat tgcttccaaa catttttgga taagaccatg   2460

agtattgaat tccccgagat gttagctgaa atcatcacca atcagatacc aaaatattca   2520

aatggaaata tcaaaaaact tctgtttcat caaaagtgac tgccttaata agaatggttg   2580

ccttaaagaa agtcgaatta atagctttta ttgtataaac tatcagtttg tcctgtagag   2640

gttttgttgt tttatttttt attgttttca tctgttgttt tgttttaaat acgcactaca   2700

tgtggtttat agagggccaa gacttggcaa cagaagcagt tgagtcgtca tcacttttca   2760

gtgatgggag agtagatggt gaaatttatt agttaatata tcccagaaat tagaaacctt   2820

aatatgtgga cgtaatctcc acagtcaaag aaggatggca cctaaaccac cagtgcccaa   2880

agtctgtgtg atgaactttc tcttcatact ttttttcaca gttggctgga tgaaattttc   2940

tagactttct gttggtgtat cccccccctg tatagttagg atagcatttt tgatttatgc   3000

atggaaacct gaaaaaaagt ttacaagtgt atatcagaaa agggaagttg tgccttttat   3060

agctattact gtctggtttt aacaatttcc tttatattta gtgaactacg cttgctcatt   3120

ttttcttaca taatttttta ttcaagttat tgtacagctg tttaagatgg gcagctagtt   3180

cgtagctttc ccaaataaac tctaaacatt aatcaatcat ctgtgtgaaa atgggttggt   3240

gcttctaacc tgatggcact tagctatcag aagaccacaa aaattgactc aaatctccag   3300

tattcttgtc aaaaaaaaaa aaaaaaaagc tcatattttg tatatatctg cttcagtgga   3360

gaattatata ggttgtgcaa attaacagtc ctaactggta tagagcacct agtccagtga   3420

cctgctgggt aaactgtgga tgatggttgc aaaagactaa tttaaaaaat aactaccaag   3480

aggccctgtc tgtacctaac gccctatttt tgcaatggct atatggcaag aaagctggta   3540

aactatttgt ctttcaggac cttttgaagt agtttgtata acttcttaaa agttgtgatt   3600

ccagataacc agctgtaaca cagctgagag acttttaatc agacaaagta attcctctca   3660

ctaaacttta cccaaaaact aaatctctaa tatggcaaaa atggctagac acccattttc   3720

acattcccat ctgtcaccaa ttggttaatc tttcctgatg gtacaggaaa gctcagctac   3780

tgatttttgt gatttagaac tgtatgtcag acatccatgt ttgtaaaact acacatccct   3840

aatgtgtgcc atagagttta acacaagtcc tgtgaatttc ttcactgttg aaaattattt   3900

taaacaaaat agaagctgta gtagcccttt ctgtgtgcac cttaccaact ttctgtaaac   3960

tcaaaactta acatatttac taagccacaa gaaatttgat ttctattcaa ggtggccaaa   4020

ttatttgtgt aatagaaaac tgaaaatcta atattaaaaa tatggaactt ctaatatatt   4080

tttatattta gttatagttt cagatatata tcatattggt attcactaat ctgggaaggg   4140

aagggctact gcagctttac atgcaattta ttaaaatgat tgtaaaatag cttgtatagt   4200

gtaaaataag aatgattttt agatgagatt gttttatcat gacatgttat atattttttg   4260

taggggtcaa agaaatgctg atggataacc tatatgattt atagtttgta catgcattca   4320

tacaggcagc gatggtctca gaaaccaaac agtttgctct aggggaagag ggagatggag   4380

actggtcctg tgtgcagtga aggttgctga ggctctgacc cagtgagatt acagaggaag   4440

ttatcctctg cctcccattc tgaccaccct tctcattcca acagtgagtc tgtcagcgca   4500

ggtttagttt actcaatctc cccttgcact aaagtatgta aagtatgtaa acaggagaca   4560

ggaaggtggt gcttacatcc ttaaaggcac catctaatag cgggttactt tcacatacag   4620

ccctccccca gcagttgaat gacaacagaa gcttcagaag tttggcaata gtttgcatag   4680

aggtaccagc aatatgtaaa tagtgcagaa tctcataggt tgccaataat acactaattc   4740

ctttctatcc tacaacaaga gtttatttcc aaataaaatg aggacatgtt tttgttttct   4800

ttgaatgctt tttgaatgtt atttgttatt ttcagtattt tggagaaatt atttaataaa   4860

aaaacaatca tttgcttttt gaatgctctc taaaagggaa tgtaatattt taagatggtg   4920

tgtaacccgg ctggataaat ttttggtgcc taagaaaact gcttgaatat tcttatcaat   4980

gacagtgtta agtttcaaaa agagcttcta aaacgtagat tatcattcct ttatagaatg   5040

ttatgtggtt aaaaccagaa agcacatctc acacattaat ctgattttca tcccaacaat   5100

cttggcgctc aaaaaataga actcaatgag aaaaagaaga ttatgtgcac ttcgttgtca   5160

ataataagtc aactgatgct catcgacaac tataggaggc ttttcattaa atgggaaaag   5220

aagctgtgcc cttttaggat acgtggggga aaagaaagtc atcttaatta tgtttaattg   5280

tggatttaag tgctatatgg tggtgctgtt tgaaagcaga tttatttcct atgtatgtgt   5340

tatctggcca tcccaaccca aactgttgaa gtttgtagta acttcagtga gagttggtta   5400

ctcacaacaa atcctgaaaa gtatttttag tgtttgtagg tattctgtgg gatactatac   5460

aagcagaact gaggcactta ggacataaca cttttggggt atatatatcc aaatgcctaa   5520

aactatggga ggaaaccttg gccaccccaa aaggaaaact aacatgattt gtgtctatga   5580

agtgctggat aattagcatg ggatgagctc tgggcatgcc atgaaggaaa gccacgctcc   5640

cttcagaatt cagaggcagg gagcaattcc agtttcacct aagtctcata attttagttc   5700

ccttttaaaa accctgaaaa ctacatcacc atggaatgaa aaatattgtt atacaataca   5760

ttgatctgtc aaacttccag aaccatggta gccttcagtg agatttccat cttggctggt   5820

cactccctga ctgtagctgt aggtgaatgt gtttttgtgt gtgtgtgtct ggttttagtg   5880

tcagaaggga aataaaagtg taaggaggac actttaaacc ctttgggtgg agtttcgtaa   5940

tttcccagac tattttcaag caacctggtc cacccaggat tagtgaccag gttttcagga   6000

aaggatttgc ttctctctag aaaatgtctg aaaggatttt attttctgat gaaaggctgt   6060

atgaaaatac cctcctcaaa taacttgctt aactacatat agattcaagt gtgtcaatat   6120

tctattttgt atattaaatg ctatataatg gggacaaatc tatattatac tgtgtatggc   6180

attattaaga agctttttca ttatttttta tcacagtaat tttaaaatgt gtaaaaatta   6240

aaaccagtga ctcctgttta aaaataaaag ttgtagtttt ttattcatgc tgaataataa   6300

tctgtagtta aaaaaaaagt gtctttttac ctacgcagtg aaatgtcaga ctgtaaaacc   6360

ttgtgtggaa atgtttaact tttatttttt catttaaatt tgctgttctg gtattaccaa   6420

accacacatt tgtaccgaat tggcagtaaa tgttagccat ttacagcaat gccaaatatg   6480

gagaaacatc ataataaaaa aatctgcttt ttcatta                            6517


<210>  288
<211>  777
<212>  PRT
<213>  Homo sapiens

<400>  288


Met Asp Ser Lys Glu Ser Leu Thr Pro Gly Arg Glu Glu Asn Pro Ser 
1               5                   10                  15      


Ser Val Leu Ala Gln Glu Arg Gly Asp Val Met Asp Phe Tyr Lys Thr 
            20                  25                  30          


Leu Arg Gly Gly Ala Thr Val Lys Val Ser Ala Ser Ser Pro Ser Leu 
        35                  40                  45              


Ala Val Ala Ser Gln Ser Asp Ser Lys Gln Arg Arg Leu Leu Val Asp 
    50                  55                  60                  


Phe Pro Lys Gly Ser Val Ser Asn Ala Gln Gln Pro Asp Leu Ser Lys 
65                  70                  75                  80  


Ala Val Ser Leu Ser Met Gly Leu Tyr Met Gly Glu Thr Glu Thr Lys 
                85                  90                  95      


Val Met Gly Asn Asp Leu Gly Phe Pro Gln Gln Gly Gln Ile Ser Leu 
            100                 105                 110         


Ser Ser Gly Glu Thr Asp Leu Lys Leu Leu Glu Glu Ser Ile Ala Asn 
        115                 120                 125             


Leu Asn Arg Ser Thr Ser Val Pro Glu Asn Pro Lys Ser Ser Ala Ser 
    130                 135                 140                 


Thr Ala Val Ser Ala Ala Pro Thr Glu Lys Glu Phe Pro Lys Thr His 
145                 150                 155                 160 


Ser Asp Val Ser Ser Glu Gln Gln His Leu Lys Gly Gln Thr Gly Thr 
                165                 170                 175     


Asn Gly Gly Asn Val Lys Leu Tyr Thr Thr Asp Gln Ser Thr Phe Asp 
            180                 185                 190         


Ile Leu Gln Asp Leu Glu Phe Ser Ser Gly Ser Pro Gly Lys Glu Thr 
        195                 200                 205             


Asn Glu Ser Pro Trp Arg Ser Asp Leu Leu Ile Asp Glu Asn Cys Leu 
    210                 215                 220                 


Leu Ser Pro Leu Ala Gly Glu Asp Asp Ser Phe Leu Leu Glu Gly Asn 
225                 230                 235                 240 


Ser Asn Glu Asp Cys Lys Pro Leu Ile Leu Pro Asp Thr Lys Pro Lys 
                245                 250                 255     


Ile Lys Asp Asn Gly Asp Leu Val Leu Ser Ser Pro Ser Asn Val Thr 
            260                 265                 270         


Leu Pro Gln Val Lys Thr Glu Lys Glu Asp Phe Ile Glu Leu Cys Thr 
        275                 280                 285             


Pro Gly Val Ile Lys Gln Glu Lys Leu Gly Thr Val Tyr Cys Gln Ala 
    290                 295                 300                 


Ser Phe Pro Gly Ala Asn Ile Ile Gly Asn Lys Met Ser Ala Ile Ser 
305                 310                 315                 320 


Val His Gly Val Ser Thr Ser Gly Gly Gln Met Tyr His Tyr Asp Met 
                325                 330                 335     


Asn Thr Ala Ser Leu Ser Gln Gln Gln Asp Gln Lys Pro Ile Phe Asn 
            340                 345                 350         


Val Ile Pro Pro Ile Pro Val Gly Ser Glu Asn Trp Asn Arg Cys Gln 
        355                 360                 365             


Gly Ser Gly Asp Asp Asn Leu Thr Ser Leu Gly Thr Leu Asn Phe Pro 
    370                 375                 380                 


Gly Arg Thr Val Phe Ser Asn Gly Tyr Ser Ser Pro Ser Met Arg Pro 
385                 390                 395                 400 


Asp Val Ser Ser Pro Pro Ser Ser Ser Ser Thr Ala Thr Thr Gly Pro 
                405                 410                 415     


Pro Pro Lys Leu Cys Leu Val Cys Ser Asp Glu Ala Ser Gly Cys His 
            420                 425                 430         


Tyr Gly Val Leu Thr Cys Gly Ser Cys Lys Val Phe Phe Lys Arg Ala 
        435                 440                 445             


Val Glu Gly Gln His Asn Tyr Leu Cys Ala Gly Arg Asn Asp Cys Ile 
    450                 455                 460                 


Ile Asp Lys Ile Arg Arg Lys Asn Cys Pro Ala Cys Arg Tyr Arg Lys 
465                 470                 475                 480 


Cys Leu Gln Ala Gly Met Asn Leu Glu Ala Arg Lys Thr Lys Lys Lys 
                485                 490                 495     


Ile Lys Gly Ile Gln Gln Ala Thr Thr Gly Val Ser Gln Glu Thr Ser 
            500                 505                 510         


Glu Asn Pro Gly Asn Lys Thr Ile Val Pro Ala Thr Leu Pro Gln Leu 
        515                 520                 525             


Thr Pro Thr Leu Val Ser Leu Leu Glu Val Ile Glu Pro Glu Val Leu 
    530                 535                 540                 


Tyr Ala Gly Tyr Asp Ser Ser Val Pro Asp Ser Thr Trp Arg Ile Met 
545                 550                 555                 560 


Thr Thr Leu Asn Met Leu Gly Gly Arg Gln Val Ile Ala Ala Val Lys 
                565                 570                 575     


Trp Ala Lys Ala Ile Pro Gly Phe Arg Asn Leu His Leu Asp Asp Gln 
            580                 585                 590         


Met Thr Leu Leu Gln Tyr Ser Trp Met Phe Leu Met Ala Phe Ala Leu 
        595                 600                 605             


Gly Trp Arg Ser Tyr Arg Gln Ser Ser Ala Asn Leu Leu Cys Phe Ala 
    610                 615                 620                 


Pro Asp Leu Ile Ile Asn Glu Gln Arg Met Thr Leu Pro Cys Met Tyr 
625                 630                 635                 640 


Asp Gln Cys Lys His Met Leu Tyr Val Ser Ser Glu Leu His Arg Leu 
                645                 650                 655     


Gln Val Ser Tyr Glu Glu Tyr Leu Cys Met Lys Thr Leu Leu Leu Leu 
            660                 665                 670         


Ser Ser Val Pro Lys Asp Gly Leu Lys Ser Gln Glu Leu Phe Asp Glu 
        675                 680                 685             


Ile Arg Met Thr Tyr Ile Lys Glu Leu Gly Lys Ala Ile Val Lys Arg 
    690                 695                 700                 


Glu Gly Asn Ser Ser Gln Asn Trp Gln Arg Phe Tyr Gln Leu Thr Lys 
705                 710                 715                 720 


Leu Leu Asp Ser Met His Glu Val Val Glu Asn Leu Leu Asn Tyr Cys 
                725                 730                 735     


Phe Gln Thr Phe Leu Asp Lys Thr Met Ser Ile Glu Phe Pro Glu Met 
            740                 745                 750         


Leu Ala Glu Ile Ile Thr Asn Gln Ile Pro Lys Tyr Ser Asn Gly Asn 
        755                 760                 765             


Ile Lys Lys Leu Leu Phe His Gln Lys 
    770                 775         

<210>  289
<211>  6410
<212>  DNA
<213>  Homo sapiens

<400>  289
cttctctccc agtgcgagag cgcggcggcg gcagctgaag acccggccgc ccagatgatg     60

cggtggtggg ggacctgccg gcacgcgact ccccccgggc ccaaattgat attcactgat    120

ggactccaaa gaatcattaa ctcctggtag agaagaaaac cccagcagtg tgcttgctca    180

ggagagggga gatgtgatgg acttctataa aaccctaaga ggaggagcta ctgtgaaggt    240

ttctgcgtct tcaccctcac tggctgtcgc ttctcaatca gactccaagc agcgaagact    300

tttggttgat tttccaaaag gctcagtaag caatgcgcag cagccagatc tgtccaaagc    360

agtttcactc tcaatgggac tgtatatggg agagacagaa acaaaagtga tgggaaatga    420

cctgggattc ccacagcagg gccaaatcag cctttcctcg ggggaaacag acttaaagct    480

tttggaagaa agcattgcaa acctcaatag gtcgaccagt gttccagaga accccaagag    540

ttcagcatcc actgctgtgt ctgctgcccc cacagagaag gagtttccaa aaactcactc    600

tgatgtatct tcagaacagc aacatttgaa gggccagact ggcaccaacg gtggcaatgt    660

gaaattgtat accacagacc aaagcacctt tgacattttg caggatttgg agttttcttc    720

tgggtcccca ggtaaagaga cgaatgagag tccttggaga tcagacctgt tgatagatga    780

aaactgtttg ctttctcctc tggcgggaga agacgattca ttccttttgg aaggaaactc    840

gaatgaggac tgcaagcctc tcattttacc ggacactaaa cccaaaatta aggataatgg    900

agatctggtt ttgtcaagcc ccagtaatgt aacactgccc caagtgaaaa cagaaaaaga    960

agatttcatc gaactctgca cccctggggt aattaagcaa gagaaactgg gcacagttta   1020

ctgtcaggca agctttcctg gagcaaatat aattggtaat aaaatgtctg ccatttctgt   1080

tcatggtgtg agtacctctg gaggacagat gtaccactat gacatgaata cagcatccct   1140

ttctcaacag caggatcaga agcctatttt taatgtcatt ccaccaattc ccgttggttc   1200

cgaaaattgg aataggtgcc aaggatctgg agatgacaac ttgacttctc tggggactct   1260

gaacttccct ggtcgaacag ttttttctaa tggctattca agccccagca tgagaccaga   1320

tgtaagctct cctccatcca gctcctcaac agcaacaaca ggaccacctc ccaaactctg   1380

cctggtgtgc tctgatgaag cttcaggatg tcattatgga gtcttaactt gtggaagctg   1440

taaagttttc ttcaaaagag cagtggaagg acagcacaat tacctatgtg ctggaaggaa   1500

tgattgcatc atcgataaaa ttcgaagaaa aaactgccca gcatgccgct atcgaaaatg   1560

tcttcaggct ggaatgaacc tggaagctcg aaaaacaaag aaaaaaataa aaggaattca   1620

gcaggccact acaggagtct cacaagaaac ctctgaaaat cctggtaaca aaacaatagt   1680

tcctgcaacg ttaccacaac tcacccctac cctggtgtca ctgttggagg ttattgaacc   1740

tgaagtgtta tatgcaggat atgatagctc tgttccagac tcaacttgga ggatcatgac   1800

tacgctcaac atgttaggag ggcggcaagt gattgcagca gtgaaatggg caaaggcaat   1860

accaggtttc aggaacttac acctggatga ccaaatgacc ctactgcagt actcctggat   1920

gtttcttatg gcatttgctc tggggtggag atcatataga caatcaagtg caaacctgct   1980

gtgttttgct cctgatctga ttattaatga gcagagaatg actctaccct gcatgtacga   2040

ccaatgtaaa cacatgctgt atgtttcctc tgagttacac aggcttcagg tatcttatga   2100

agagtatctc tgtatgaaaa ccttactgct tctctcttca gttcctaagg acggtctgaa   2160

gagccaagag ctatttgatg aaattagaat gacctacatc aaagagctag gaaaagccat   2220

tgtcaagagg gaaggaaact ccagccagaa ctggcagcgg ttttatcaac tgacaaaact   2280

cttggattct atgcatgaag tggttgaaaa tctccttaac tattgcttcc aaacattttt   2340

ggataagacc atgagtattg aattccccga gatgttagct gaaatcatca ccaatcagat   2400

accaaaatat tcaaatggaa atatcaaaaa acttctgttt catcaaaagt gactgcctta   2460

ataagaatgg ttgccttaaa gaaagtcgaa ttaatagctt ttattgtata aactatcagt   2520

ttgtcctgta gaggttttgt tgttttattt tttattgttt tcatctgttg ttttgtttta   2580

aatacgcact acatgtggtt tatagagggc caagacttgg caacagaagc agttgagtcg   2640

tcatcacttt tcagtgatgg gagagtagat ggtgaaattt attagttaat atatcccaga   2700

aattagaaac cttaatatgt ggacgtaatc tccacagtca aagaaggatg gcacctaaac   2760

caccagtgcc caaagtctgt gtgatgaact ttctcttcat actttttttc acagttggct   2820

ggatgaaatt ttctagactt tctgttggtg tatccccccc ctgtatagtt aggatagcat   2880

ttttgattta tgcatggaaa cctgaaaaaa agtttacaag tgtatatcag aaaagggaag   2940

ttgtgccttt tatagctatt actgtctggt tttaacaatt tcctttatat ttagtgaact   3000

acgcttgctc attttttctt acataatttt ttattcaagt tattgtacag ctgtttaaga   3060

tgggcagcta gttcgtagct ttcccaaata aactctaaac attaatcaat catctgtgtg   3120

aaaatgggtt ggtgcttcta acctgatggc acttagctat cagaagacca caaaaattga   3180

ctcaaatctc cagtattctt gtcaaaaaaa aaaaaaaaaa agctcatatt ttgtatatat   3240

ctgcttcagt ggagaattat ataggttgtg caaattaaca gtcctaactg gtatagagca   3300

cctagtccag tgacctgctg ggtaaactgt ggatgatggt tgcaaaagac taatttaaaa   3360

aataactacc aagaggccct gtctgtacct aacgccctat ttttgcaatg gctatatggc   3420

aagaaagctg gtaaactatt tgtctttcag gaccttttga agtagtttgt ataacttctt   3480

aaaagttgtg attccagata accagctgta acacagctga gagactttta atcagacaaa   3540

gtaattcctc tcactaaact ttacccaaaa actaaatctc taatatggca aaaatggcta   3600

gacacccatt ttcacattcc catctgtcac caattggtta atctttcctg atggtacagg   3660

aaagctcagc tactgatttt tgtgatttag aactgtatgt cagacatcca tgtttgtaaa   3720

actacacatc cctaatgtgt gccatagagt ttaacacaag tcctgtgaat ttcttcactg   3780

ttgaaaatta ttttaaacaa aatagaagct gtagtagccc tttctgtgtg caccttacca   3840

actttctgta aactcaaaac ttaacatatt tactaagcca caagaaattt gatttctatt   3900

caaggtggcc aaattatttg tgtaatagaa aactgaaaat ctaatattaa aaatatggaa   3960

cttctaatat atttttatat ttagttatag tttcagatat atatcatatt ggtattcact   4020

aatctgggaa gggaagggct actgcagctt tacatgcaat ttattaaaat gattgtaaaa   4080

tagcttgtat agtgtaaaat aagaatgatt tttagatgag attgttttat catgacatgt   4140

tatatatttt ttgtaggggt caaagaaatg ctgatggata acctatatga tttatagttt   4200

gtacatgcat tcatacaggc agcgatggtc tcagaaacca aacagtttgc tctaggggaa   4260

gagggagatg gagactggtc ctgtgtgcag tgaaggttgc tgaggctctg acccagtgag   4320

attacagagg aagttatcct ctgcctccca ttctgaccac ccttctcatt ccaacagtga   4380

gtctgtcagc gcaggtttag tttactcaat ctccccttgc actaaagtat gtaaagtatg   4440

taaacaggag acaggaaggt ggtgcttaca tccttaaagg caccatctaa tagcgggtta   4500

ctttcacata cagccctccc ccagcagttg aatgacaaca gaagcttcag aagtttggca   4560

atagtttgca tagaggtacc agcaatatgt aaatagtgca gaatctcata ggttgccaat   4620

aatacactaa ttcctttcta tcctacaaca agagtttatt tccaaataaa atgaggacat   4680

gtttttgttt tctttgaatg ctttttgaat gttatttgtt attttcagta ttttggagaa   4740

attatttaat aaaaaaacaa tcatttgctt tttgaatgct ctctaaaagg gaatgtaata   4800

ttttaagatg gtgtgtaacc cggctggata aatttttggt gcctaagaaa actgcttgaa   4860

tattcttatc aatgacagtg ttaagtttca aaaagagctt ctaaaacgta gattatcatt   4920

cctttataga atgttatgtg gttaaaacca gaaagcacat ctcacacatt aatctgattt   4980

tcatcccaac aatcttggcg ctcaaaaaat agaactcaat gagaaaaaga agattatgtg   5040

cacttcgttg tcaataataa gtcaactgat gctcatcgac aactatagga ggcttttcat   5100

taaatgggaa aagaagctgt gcccttttag gatacgtggg ggaaaagaaa gtcatcttaa   5160

ttatgtttaa ttgtggattt aagtgctata tggtggtgct gtttgaaagc agatttattt   5220

cctatgtatg tgttatctgg ccatcccaac ccaaactgtt gaagtttgta gtaacttcag   5280

tgagagttgg ttactcacaa caaatcctga aaagtatttt tagtgtttgt aggtattctg   5340

tgggatacta tacaagcaga actgaggcac ttaggacata acacttttgg ggtatatata   5400

tccaaatgcc taaaactatg ggaggaaacc ttggccaccc caaaaggaaa actaacatga   5460

tttgtgtcta tgaagtgctg gataattagc atgggatgag ctctgggcat gccatgaagg   5520

aaagccacgc tcccttcaga attcagaggc agggagcaat tccagtttca cctaagtctc   5580

ataattttag ttccctttta aaaaccctga aaactacatc accatggaat gaaaaatatt   5640

gttatacaat acattgatct gtcaaacttc cagaaccatg gtagccttca gtgagatttc   5700

catcttggct ggtcactccc tgactgtagc tgtaggtgaa tgtgtttttg tgtgtgtgtg   5760

tctggtttta gtgtcagaag ggaaataaaa gtgtaaggag gacactttaa accctttggg   5820

tggagtttcg taatttccca gactattttc aagcaacctg gtccacccag gattagtgac   5880

caggttttca ggaaaggatt tgcttctctc tagaaaatgt ctgaaaggat tttattttct   5940

gatgaaaggc tgtatgaaaa taccctcctc aaataacttg cttaactaca tatagattca   6000

agtgtgtcaa tattctattt tgtatattaa atgctatata atggggacaa atctatatta   6060

tactgtgtat ggcattatta agaagctttt tcattatttt ttatcacagt aattttaaaa   6120

tgtgtaaaaa ttaaaaccag tgactcctgt ttaaaaataa aagttgtagt tttttattca   6180

tgctgaataa taatctgtag ttaaaaaaaa agtgtctttt tacctacgca gtgaaatgtc   6240

agactgtaaa accttgtgtg gaaatgttta acttttattt tttcatttaa atttgctgtt   6300

ctggtattac caaaccacac atttgtaccg aattggcagt aaatgttagc catttacagc   6360

aatgccaaat atggagaaac atcataataa aaaaatctgc tttttcatta              6410


<210>  290
<211>  777
<212>  PRT
<213>  Homo sapiens

<400>  290


Met Asp Ser Lys Glu Ser Leu Thr Pro Gly Arg Glu Glu Asn Pro Ser 
1               5                   10                  15      


Ser Val Leu Ala Gln Glu Arg Gly Asp Val Met Asp Phe Tyr Lys Thr 
            20                  25                  30          


Leu Arg Gly Gly Ala Thr Val Lys Val Ser Ala Ser Ser Pro Ser Leu 
        35                  40                  45              


Ala Val Ala Ser Gln Ser Asp Ser Lys Gln Arg Arg Leu Leu Val Asp 
    50                  55                  60                  


Phe Pro Lys Gly Ser Val Ser Asn Ala Gln Gln Pro Asp Leu Ser Lys 
65                  70                  75                  80  


Ala Val Ser Leu Ser Met Gly Leu Tyr Met Gly Glu Thr Glu Thr Lys 
                85                  90                  95      


Val Met Gly Asn Asp Leu Gly Phe Pro Gln Gln Gly Gln Ile Ser Leu 
            100                 105                 110         


Ser Ser Gly Glu Thr Asp Leu Lys Leu Leu Glu Glu Ser Ile Ala Asn 
        115                 120                 125             


Leu Asn Arg Ser Thr Ser Val Pro Glu Asn Pro Lys Ser Ser Ala Ser 
    130                 135                 140                 


Thr Ala Val Ser Ala Ala Pro Thr Glu Lys Glu Phe Pro Lys Thr His 
145                 150                 155                 160 


Ser Asp Val Ser Ser Glu Gln Gln His Leu Lys Gly Gln Thr Gly Thr 
                165                 170                 175     


Asn Gly Gly Asn Val Lys Leu Tyr Thr Thr Asp Gln Ser Thr Phe Asp 
            180                 185                 190         


Ile Leu Gln Asp Leu Glu Phe Ser Ser Gly Ser Pro Gly Lys Glu Thr 
        195                 200                 205             


Asn Glu Ser Pro Trp Arg Ser Asp Leu Leu Ile Asp Glu Asn Cys Leu 
    210                 215                 220                 


Leu Ser Pro Leu Ala Gly Glu Asp Asp Ser Phe Leu Leu Glu Gly Asn 
225                 230                 235                 240 


Ser Asn Glu Asp Cys Lys Pro Leu Ile Leu Pro Asp Thr Lys Pro Lys 
                245                 250                 255     


Ile Lys Asp Asn Gly Asp Leu Val Leu Ser Ser Pro Ser Asn Val Thr 
            260                 265                 270         


Leu Pro Gln Val Lys Thr Glu Lys Glu Asp Phe Ile Glu Leu Cys Thr 
        275                 280                 285             


Pro Gly Val Ile Lys Gln Glu Lys Leu Gly Thr Val Tyr Cys Gln Ala 
    290                 295                 300                 


Ser Phe Pro Gly Ala Asn Ile Ile Gly Asn Lys Met Ser Ala Ile Ser 
305                 310                 315                 320 


Val His Gly Val Ser Thr Ser Gly Gly Gln Met Tyr His Tyr Asp Met 
                325                 330                 335     


Asn Thr Ala Ser Leu Ser Gln Gln Gln Asp Gln Lys Pro Ile Phe Asn 
            340                 345                 350         


Val Ile Pro Pro Ile Pro Val Gly Ser Glu Asn Trp Asn Arg Cys Gln 
        355                 360                 365             


Gly Ser Gly Asp Asp Asn Leu Thr Ser Leu Gly Thr Leu Asn Phe Pro 
    370                 375                 380                 


Gly Arg Thr Val Phe Ser Asn Gly Tyr Ser Ser Pro Ser Met Arg Pro 
385                 390                 395                 400 


Asp Val Ser Ser Pro Pro Ser Ser Ser Ser Thr Ala Thr Thr Gly Pro 
                405                 410                 415     


Pro Pro Lys Leu Cys Leu Val Cys Ser Asp Glu Ala Ser Gly Cys His 
            420                 425                 430         


Tyr Gly Val Leu Thr Cys Gly Ser Cys Lys Val Phe Phe Lys Arg Ala 
        435                 440                 445             


Val Glu Gly Gln His Asn Tyr Leu Cys Ala Gly Arg Asn Asp Cys Ile 
    450                 455                 460                 


Ile Asp Lys Ile Arg Arg Lys Asn Cys Pro Ala Cys Arg Tyr Arg Lys 
465                 470                 475                 480 


Cys Leu Gln Ala Gly Met Asn Leu Glu Ala Arg Lys Thr Lys Lys Lys 
                485                 490                 495     


Ile Lys Gly Ile Gln Gln Ala Thr Thr Gly Val Ser Gln Glu Thr Ser 
            500                 505                 510         


Glu Asn Pro Gly Asn Lys Thr Ile Val Pro Ala Thr Leu Pro Gln Leu 
        515                 520                 525             


Thr Pro Thr Leu Val Ser Leu Leu Glu Val Ile Glu Pro Glu Val Leu 
    530                 535                 540                 


Tyr Ala Gly Tyr Asp Ser Ser Val Pro Asp Ser Thr Trp Arg Ile Met 
545                 550                 555                 560 


Thr Thr Leu Asn Met Leu Gly Gly Arg Gln Val Ile Ala Ala Val Lys 
                565                 570                 575     


Trp Ala Lys Ala Ile Pro Gly Phe Arg Asn Leu His Leu Asp Asp Gln 
            580                 585                 590         


Met Thr Leu Leu Gln Tyr Ser Trp Met Phe Leu Met Ala Phe Ala Leu 
        595                 600                 605             


Gly Trp Arg Ser Tyr Arg Gln Ser Ser Ala Asn Leu Leu Cys Phe Ala 
    610                 615                 620                 


Pro Asp Leu Ile Ile Asn Glu Gln Arg Met Thr Leu Pro Cys Met Tyr 
625                 630                 635                 640 


Asp Gln Cys Lys His Met Leu Tyr Val Ser Ser Glu Leu His Arg Leu 
                645                 650                 655     


Gln Val Ser Tyr Glu Glu Tyr Leu Cys Met Lys Thr Leu Leu Leu Leu 
            660                 665                 670         


Ser Ser Val Pro Lys Asp Gly Leu Lys Ser Gln Glu Leu Phe Asp Glu 
        675                 680                 685             


Ile Arg Met Thr Tyr Ile Lys Glu Leu Gly Lys Ala Ile Val Lys Arg 
    690                 695                 700                 


Glu Gly Asn Ser Ser Gln Asn Trp Gln Arg Phe Tyr Gln Leu Thr Lys 
705                 710                 715                 720 


Leu Leu Asp Ser Met His Glu Val Val Glu Asn Leu Leu Asn Tyr Cys 
                725                 730                 735     


Phe Gln Thr Phe Leu Asp Lys Thr Met Ser Ile Glu Phe Pro Glu Met 
            740                 745                 750         


Leu Ala Glu Ile Ile Thr Asn Gln Ile Pro Lys Tyr Ser Asn Gly Asn 
        755                 760                 765             


Ile Lys Lys Leu Leu Phe His Gln Lys 
    770                 775         

<210>  291
<211>  7286
<212>  DNA
<213>  Homo sapiens

<400>  291
aggttatgta agggtttgct ttcaccccat tcaaaaggta cctcttcctc ttctcttgct     60

ccctctcgcc ctcattcttg tgcctatgca gacatttgag tagaggcgaa tcactttcac    120

ttctgctggg gaaattgcaa cacgcttctt taaatggcag agagaaggag aaaacttaga    180

tcttctgata ccaaatcact ggaccttaga aggtcagaaa tctttcaagc cctgcaggac    240

cgtaaaatgc gcatgtgtcc aacggaagca ctggggcatg agtggggaag gaatagaaac    300

agaaagaggg taagagaaga aaaaagggaa agtggtgaag gcagggagga aaattgctta    360

gtgtgaatat gcacgcattc atttagtttt caaatccttg ttgagcatga taaaattccc    420

agcatcagac ctcacatgtt ggtttccatt aggatctgcc tgggggaata tctgctgaat    480

cagtggctct gagctgaact aggaaattca ccataattag gagagtcact gtatttctct    540

ccaaaaaaaa aaaagttata cccgagagac aggatcttct gatctgaaat tttcttcact    600

tctgaaattc tctggtttgt gctcatcgtt ggtagctatt tgttcatcaa gagttgtgta    660

gctggcttct tctgaaaaaa ggaatctgcg tcatatctaa gtcagatttc attctggtgc    720

tctcagagca gttagcccag gaaaggggcc agcttctgtg acgactgctg cagaggcagg    780

tgcagtttgt gtgccacaga tattaacttt gataagcact taatgagtgc cttctctgtg    840

cgagaatggg gaggaacaaa atgcagctcc taccctcctc gggctttagt tgtaccttaa    900

taacaggaat tttcatctgc ctggctcctt tcctcaaaga acaaagaaga ctttgcttca    960

ttaaagtgtc tgagaaggaa gttgatattc actgatggac tccaaagaat cattaactcc   1020

tggtagagaa gaaaacccca gcagtgtgct tgctcaggag aggggagatg tgatggactt   1080

ctataaaacc ctaagaggag gagctactgt gaaggtttct gcgtcttcac cctcactggc   1140

tgtcgcttct caatcagact ccaagcagcg aagacttttg gttgattttc caaaaggctc   1200

agtaagcaat gcgcagcagc cagatctgtc caaagcagtt tcactctcaa tgggactgta   1260

tatgggagag acagaaacaa aagtgatggg aaatgacctg ggattcccac agcagggcca   1320

aatcagcctt tcctcggggg aaacagactt aaagcttttg gaagaaagca ttgcaaacct   1380

caataggtcg accagtgttc cagagaaccc caagagttca gcatccactg ctgtgtctgc   1440

tgcccccaca gagaaggagt ttccaaaaac tcactctgat gtatcttcag aacagcaaca   1500

tttgaagggc cagactggca ccaacggtgg caatgtgaaa ttgtatacca cagaccaaag   1560

cacctttgac attttgcagg atttggagtt ttcttctggg tccccaggta aagagacgaa   1620

tgagagtcct tggagatcag acctgttgat agatgaaaac tgtttgcttt ctcctctggc   1680

gggagaagac gattcattcc ttttggaagg aaactcgaat gaggactgca agcctctcat   1740

tttaccggac actaaaccca aaattaagga taatggagat ctggttttgt caagccccag   1800

taatgtaaca ctgccccaag tgaaaacaga aaaagaagat ttcatcgaac tctgcacccc   1860

tggggtaatt aagcaagaga aactgggcac agtttactgt caggcaagct ttcctggagc   1920

aaatataatt ggtaataaaa tgtctgccat ttctgttcat ggtgtgagta cctctggagg   1980

acagatgtac cactatgaca tgaatacagc atccctttct caacagcagg atcagaagcc   2040

tatttttaat gtcattccac caattcccgt tggttccgaa aattggaata ggtgccaagg   2100

atctggagat gacaacttga cttctctggg gactctgaac ttccctggtc gaacagtttt   2160

ttctaatggc tattcaagcc ccagcatgag accagatgta agctctcctc catccagctc   2220

ctcaacagca acaacaggac cacctcccaa actctgcctg gtgtgctctg atgaagcttc   2280

aggatgtcat tatggagtct taacttgtgg aagctgtaaa gttttcttca aaagagcagt   2340

ggaaggacag cacaattacc tatgtgctgg aaggaatgat tgcatcatcg ataaaattcg   2400

aagaaaaaac tgcccagcat gccgctatcg aaaatgtctt caggctggaa tgaacctgga   2460

agctcgaaaa acaaagaaaa aaataaaagg aattcagcag gccactacag gagtctcaca   2520

agaaacctct gaaaatcctg gtaacaaaac aatagttcct gcaacgttac cacaactcac   2580

ccctaccctg gtgtcactgt tggaggttat tgaacctgaa gtgttatatg caggatatga   2640

tagctctgtt ccagactcaa cttggaggat catgactacg ctcaacatgt taggagggcg   2700

gcaagtgatt gcagcagtga aatgggcaaa ggcaatacca ggtttcagga acttacacct   2760

ggatgaccaa atgaccctac tgcagtactc ctggatgttt cttatggcat ttgctctggg   2820

gtggagatca tatagacaat caagtgcaaa cctgctgtgt tttgctcctg atctgattat   2880

taatgagcag agaatgactc taccctgcat gtacgaccaa tgtaaacaca tgctgtatgt   2940

ttcctctgag ttacacaggc ttcaggtatc ttatgaagag tatctctgta tgaaaacctt   3000

actgcttctc tcttcagttc ctaaggacgg tctgaagagc caagagctat ttgatgaaat   3060

tagaatgacc tacatcaaag agctaggaaa agccattgtc aagagggaag gaaactccag   3120

ccagaactgg cagcggtttt atcaactgac aaaactcttg gattctatgc atgaagtggt   3180

tgaaaatctc cttaactatt gcttccaaac atttttggat aagaccatga gtattgaatt   3240

ccccgagatg ttagctgaaa tcatcaccaa tcagatacca aaatattcaa atggaaatat   3300

caaaaaactt ctgtttcatc aaaagtgact gccttaataa gaatggttgc cttaaagaaa   3360

gtcgaattaa tagcttttat tgtataaact atcagtttgt cctgtagagg ttttgttgtt   3420

ttatttttta ttgttttcat ctgttgtttt gttttaaata cgcactacat gtggtttata   3480

gagggccaag acttggcaac agaagcagtt gagtcgtcat cacttttcag tgatgggaga   3540

gtagatggtg aaatttatta gttaatatat cccagaaatt agaaacctta atatgtggac   3600

gtaatctcca cagtcaaaga aggatggcac ctaaaccacc agtgcccaaa gtctgtgtga   3660

tgaactttct cttcatactt tttttcacag ttggctggat gaaattttct agactttctg   3720

ttggtgtatc ccccccctgt atagttagga tagcattttt gatttatgca tggaaacctg   3780

aaaaaaagtt tacaagtgta tatcagaaaa gggaagttgt gccttttata gctattactg   3840

tctggtttta acaatttcct ttatatttag tgaactacgc ttgctcattt tttcttacat   3900

aattttttat tcaagttatt gtacagctgt ttaagatggg cagctagttc gtagctttcc   3960

caaataaact ctaaacatta atcaatcatc tgtgtgaaaa tgggttggtg cttctaacct   4020

gatggcactt agctatcaga agaccacaaa aattgactca aatctccagt attcttgtca   4080

aaaaaaaaaa aaaaaaagct catattttgt atatatctgc ttcagtggag aattatatag   4140

gttgtgcaaa ttaacagtcc taactggtat agagcaccta gtccagtgac ctgctgggta   4200

aactgtggat gatggttgca aaagactaat ttaaaaaata actaccaaga ggccctgtct   4260

gtacctaacg ccctattttt gcaatggcta tatggcaaga aagctggtaa actatttgtc   4320

tttcaggacc ttttgaagta gtttgtataa cttcttaaaa gttgtgattc cagataacca   4380

gctgtaacac agctgagaga cttttaatca gacaaagtaa ttcctctcac taaactttac   4440

ccaaaaacta aatctctaat atggcaaaaa tggctagaca cccattttca cattcccatc   4500

tgtcaccaat tggttaatct ttcctgatgg tacaggaaag ctcagctact gatttttgtg   4560

atttagaact gtatgtcaga catccatgtt tgtaaaacta cacatcccta atgtgtgcca   4620

tagagtttaa cacaagtcct gtgaatttct tcactgttga aaattatttt aaacaaaata   4680

gaagctgtag tagccctttc tgtgtgcacc ttaccaactt tctgtaaact caaaacttaa   4740

catatttact aagccacaag aaatttgatt tctattcaag gtggccaaat tatttgtgta   4800

atagaaaact gaaaatctaa tattaaaaat atggaacttc taatatattt ttatatttag   4860

ttatagtttc agatatatat catattggta ttcactaatc tgggaaggga agggctactg   4920

cagctttaca tgcaatttat taaaatgatt gtaaaatagc ttgtatagtg taaaataaga   4980

atgattttta gatgagattg ttttatcatg acatgttata tattttttgt aggggtcaaa   5040

gaaatgctga tggataacct atatgattta tagtttgtac atgcattcat acaggcagcg   5100

atggtctcag aaaccaaaca gtttgctcta ggggaagagg gagatggaga ctggtcctgt   5160

gtgcagtgaa ggttgctgag gctctgaccc agtgagatta cagaggaagt tatcctctgc   5220

ctcccattct gaccaccctt ctcattccaa cagtgagtct gtcagcgcag gtttagttta   5280

ctcaatctcc ccttgcacta aagtatgtaa agtatgtaaa caggagacag gaaggtggtg   5340

cttacatcct taaaggcacc atctaatagc gggttacttt cacatacagc cctcccccag   5400

cagttgaatg acaacagaag cttcagaagt ttggcaatag tttgcataga ggtaccagca   5460

atatgtaaat agtgcagaat ctcataggtt gccaataata cactaattcc tttctatcct   5520

acaacaagag tttatttcca aataaaatga ggacatgttt ttgttttctt tgaatgcttt   5580

ttgaatgtta tttgttattt tcagtatttt ggagaaatta tttaataaaa aaacaatcat   5640

ttgctttttg aatgctctct aaaagggaat gtaatatttt aagatggtgt gtaacccggc   5700

tggataaatt tttggtgcct aagaaaactg cttgaatatt cttatcaatg acagtgttaa   5760

gtttcaaaaa gagcttctaa aacgtagatt atcattcctt tatagaatgt tatgtggtta   5820

aaaccagaaa gcacatctca cacattaatc tgattttcat cccaacaatc ttggcgctca   5880

aaaaatagaa ctcaatgaga aaaagaagat tatgtgcact tcgttgtcaa taataagtca   5940

actgatgctc atcgacaact ataggaggct tttcattaaa tgggaaaaga agctgtgccc   6000

ttttaggata cgtgggggaa aagaaagtca tcttaattat gtttaattgt ggatttaagt   6060

gctatatggt ggtgctgttt gaaagcagat ttatttccta tgtatgtgtt atctggccat   6120

cccaacccaa actgttgaag tttgtagtaa cttcagtgag agttggttac tcacaacaaa   6180

tcctgaaaag tatttttagt gtttgtaggt attctgtggg atactataca agcagaactg   6240

aggcacttag gacataacac ttttggggta tatatatcca aatgcctaaa actatgggag   6300

gaaaccttgg ccaccccaaa aggaaaacta acatgatttg tgtctatgaa gtgctggata   6360

attagcatgg gatgagctct gggcatgcca tgaaggaaag ccacgctccc ttcagaattc   6420

agaggcaggg agcaattcca gtttcaccta agtctcataa ttttagttcc cttttaaaaa   6480

ccctgaaaac tacatcacca tggaatgaaa aatattgtta tacaatacat tgatctgtca   6540

aacttccaga accatggtag ccttcagtga gatttccatc ttggctggtc actccctgac   6600

tgtagctgta ggtgaatgtg tttttgtgtg tgtgtgtctg gttttagtgt cagaagggaa   6660

ataaaagtgt aaggaggaca ctttaaaccc tttgggtgga gtttcgtaat ttcccagact   6720

attttcaagc aacctggtcc acccaggatt agtgaccagg ttttcaggaa aggatttgct   6780

tctctctaga aaatgtctga aaggatttta ttttctgatg aaaggctgta tgaaaatacc   6840

ctcctcaaat aacttgctta actacatata gattcaagtg tgtcaatatt ctattttgta   6900

tattaaatgc tatataatgg ggacaaatct atattatact gtgtatggca ttattaagaa   6960

gctttttcat tattttttat cacagtaatt ttaaaatgtg taaaaattaa aaccagtgac   7020

tcctgtttaa aaataaaagt tgtagttttt tattcatgct gaataataat ctgtagttaa   7080

aaaaaaagtg tctttttacc tacgcagtga aatgtcagac tgtaaaacct tgtgtggaaa   7140

tgtttaactt ttattttttc atttaaattt gctgttctgg tattaccaaa ccacacattt   7200

gtaccgaatt ggcagtaaat gttagccatt tacagcaatg ccaaatatgg agaaacatca   7260

taataaaaaa atctgctttt tcatta                                        7286


<210>  292
<211>  777
<212>  PRT
<213>  Homo sapiens

<400>  292


Met Asp Ser Lys Glu Ser Leu Thr Pro Gly Arg Glu Glu Asn Pro Ser 
1               5                   10                  15      


Ser Val Leu Ala Gln Glu Arg Gly Asp Val Met Asp Phe Tyr Lys Thr 
            20                  25                  30          


Leu Arg Gly Gly Ala Thr Val Lys Val Ser Ala Ser Ser Pro Ser Leu 
        35                  40                  45              


Ala Val Ala Ser Gln Ser Asp Ser Lys Gln Arg Arg Leu Leu Val Asp 
    50                  55                  60                  


Phe Pro Lys Gly Ser Val Ser Asn Ala Gln Gln Pro Asp Leu Ser Lys 
65                  70                  75                  80  


Ala Val Ser Leu Ser Met Gly Leu Tyr Met Gly Glu Thr Glu Thr Lys 
                85                  90                  95      


Val Met Gly Asn Asp Leu Gly Phe Pro Gln Gln Gly Gln Ile Ser Leu 
            100                 105                 110         


Ser Ser Gly Glu Thr Asp Leu Lys Leu Leu Glu Glu Ser Ile Ala Asn 
        115                 120                 125             


Leu Asn Arg Ser Thr Ser Val Pro Glu Asn Pro Lys Ser Ser Ala Ser 
    130                 135                 140                 


Thr Ala Val Ser Ala Ala Pro Thr Glu Lys Glu Phe Pro Lys Thr His 
145                 150                 155                 160 


Ser Asp Val Ser Ser Glu Gln Gln His Leu Lys Gly Gln Thr Gly Thr 
                165                 170                 175     


Asn Gly Gly Asn Val Lys Leu Tyr Thr Thr Asp Gln Ser Thr Phe Asp 
            180                 185                 190         


Ile Leu Gln Asp Leu Glu Phe Ser Ser Gly Ser Pro Gly Lys Glu Thr 
        195                 200                 205             


Asn Glu Ser Pro Trp Arg Ser Asp Leu Leu Ile Asp Glu Asn Cys Leu 
    210                 215                 220                 


Leu Ser Pro Leu Ala Gly Glu Asp Asp Ser Phe Leu Leu Glu Gly Asn 
225                 230                 235                 240 


Ser Asn Glu Asp Cys Lys Pro Leu Ile Leu Pro Asp Thr Lys Pro Lys 
                245                 250                 255     


Ile Lys Asp Asn Gly Asp Leu Val Leu Ser Ser Pro Ser Asn Val Thr 
            260                 265                 270         


Leu Pro Gln Val Lys Thr Glu Lys Glu Asp Phe Ile Glu Leu Cys Thr 
        275                 280                 285             


Pro Gly Val Ile Lys Gln Glu Lys Leu Gly Thr Val Tyr Cys Gln Ala 
    290                 295                 300                 


Ser Phe Pro Gly Ala Asn Ile Ile Gly Asn Lys Met Ser Ala Ile Ser 
305                 310                 315                 320 


Val His Gly Val Ser Thr Ser Gly Gly Gln Met Tyr His Tyr Asp Met 
                325                 330                 335     


Asn Thr Ala Ser Leu Ser Gln Gln Gln Asp Gln Lys Pro Ile Phe Asn 
            340                 345                 350         


Val Ile Pro Pro Ile Pro Val Gly Ser Glu Asn Trp Asn Arg Cys Gln 
        355                 360                 365             


Gly Ser Gly Asp Asp Asn Leu Thr Ser Leu Gly Thr Leu Asn Phe Pro 
    370                 375                 380                 


Gly Arg Thr Val Phe Ser Asn Gly Tyr Ser Ser Pro Ser Met Arg Pro 
385                 390                 395                 400 


Asp Val Ser Ser Pro Pro Ser Ser Ser Ser Thr Ala Thr Thr Gly Pro 
                405                 410                 415     


Pro Pro Lys Leu Cys Leu Val Cys Ser Asp Glu Ala Ser Gly Cys His 
            420                 425                 430         


Tyr Gly Val Leu Thr Cys Gly Ser Cys Lys Val Phe Phe Lys Arg Ala 
        435                 440                 445             


Val Glu Gly Gln His Asn Tyr Leu Cys Ala Gly Arg Asn Asp Cys Ile 
    450                 455                 460                 


Ile Asp Lys Ile Arg Arg Lys Asn Cys Pro Ala Cys Arg Tyr Arg Lys 
465                 470                 475                 480 


Cys Leu Gln Ala Gly Met Asn Leu Glu Ala Arg Lys Thr Lys Lys Lys 
                485                 490                 495     


Ile Lys Gly Ile Gln Gln Ala Thr Thr Gly Val Ser Gln Glu Thr Ser 
            500                 505                 510         


Glu Asn Pro Gly Asn Lys Thr Ile Val Pro Ala Thr Leu Pro Gln Leu 
        515                 520                 525             


Thr Pro Thr Leu Val Ser Leu Leu Glu Val Ile Glu Pro Glu Val Leu 
    530                 535                 540                 


Tyr Ala Gly Tyr Asp Ser Ser Val Pro Asp Ser Thr Trp Arg Ile Met 
545                 550                 555                 560 


Thr Thr Leu Asn Met Leu Gly Gly Arg Gln Val Ile Ala Ala Val Lys 
                565                 570                 575     


Trp Ala Lys Ala Ile Pro Gly Phe Arg Asn Leu His Leu Asp Asp Gln 
            580                 585                 590         


Met Thr Leu Leu Gln Tyr Ser Trp Met Phe Leu Met Ala Phe Ala Leu 
        595                 600                 605             


Gly Trp Arg Ser Tyr Arg Gln Ser Ser Ala Asn Leu Leu Cys Phe Ala 
    610                 615                 620                 


Pro Asp Leu Ile Ile Asn Glu Gln Arg Met Thr Leu Pro Cys Met Tyr 
625                 630                 635                 640 


Asp Gln Cys Lys His Met Leu Tyr Val Ser Ser Glu Leu His Arg Leu 
                645                 650                 655     


Gln Val Ser Tyr Glu Glu Tyr Leu Cys Met Lys Thr Leu Leu Leu Leu 
            660                 665                 670         


Ser Ser Val Pro Lys Asp Gly Leu Lys Ser Gln Glu Leu Phe Asp Glu 
        675                 680                 685             


Ile Arg Met Thr Tyr Ile Lys Glu Leu Gly Lys Ala Ile Val Lys Arg 
    690                 695                 700                 


Glu Gly Asn Ser Ser Gln Asn Trp Gln Arg Phe Tyr Gln Leu Thr Lys 
705                 710                 715                 720 


Leu Leu Asp Ser Met His Glu Val Val Glu Asn Leu Leu Asn Tyr Cys 
                725                 730                 735     


Phe Gln Thr Phe Leu Asp Lys Thr Met Ser Ile Glu Phe Pro Glu Met 
            740                 745                 750         


Leu Ala Glu Ile Ile Thr Asn Gln Ile Pro Lys Tyr Ser Asn Gly Asn 
        755                 760                 765             


Ile Lys Lys Leu Leu Phe His Gln Lys 
    770                 775         

<210>  293
<211>  4154
<212>  DNA
<213>  Homo sapiens

<400>  293
ggcgccgcct ccacccgctc cccgctcggt cccgctcgct cgcccaggcc gggctgccct     60

ttcgcgtgtc cgcgctctct tccctccgcc gccgcctcct ccattttgcg agctcgtgtc    120

tgtgacggga gcccgagtca ccgcctgccc gtcggggacg gattctgtgg gtggaaggag    180

acgccgcagc cggagcggcc gaagcagctg ggaccgggac ggggcacgcg cgcccggaac    240

ctcgacccgc ggagcccggc gcggggcgga gggctggctt gtcagctggg caatgggaga    300

ctttcttaaa taggggctct ccccccaccc atggagaaag gggcggctgt ttacttcctt    360

tttttagaaa aaaaaaatat atttccctcc tgctccttct gcgttcacaa gctaagttgt    420

ttatctcggc tgcggcggga actgcggacg gtggcgggcg agcggctcct ctgccagagt    480

tgatattcac tgatggactc caaagaatca ttaactcctg gtagagaaga aaaccccagc    540

agtgtgcttg ctcaggagag gggagatgtg atggacttct ataaaaccct aagaggagga    600

gctactgtga aggtttctgc gtcttcaccc tcactggctg tcgcttctca atcagactcc    660

aagcagcgaa gacttttggt tgattttcca aaaggctcag taagcaatgc gcagcagcca    720

gatctgtcca aagcagtttc actctcaatg ggactgtata tgggagagac agaaacaaaa    780

gtgatgggaa atgacctggg attcccacag cagggccaaa tcagcctttc ctcgggggaa    840

acagacttaa agcttttgga agaaagcatt gcaaacctca ataggtcgac cagtgttcca    900

gagaacccca agagttcagc atccactgct gtgtctgctg cccccacaga gaaggagttt    960

ccaaaaactc actctgatgt atcttcagaa cagcaacatt tgaagggcca gactggcacc   1020

aacggtggca atgtgaaatt gtataccaca gaccaaagca cctttgacat tttgcaggat   1080

ttggagtttt cttctgggtc cccaggtaaa gagacgaatg agagtccttg gagatcagac   1140

ctgttgatag atgaaaactg tttgctttct cctctggcgg gagaagacga ttcattcctt   1200

ttggaaggaa actcgaatga ggactgcaag cctctcattt taccggacac taaacccaaa   1260

attaaggata atggagatct ggttttgtca agccccagta atgtaacact gccccaagtg   1320

aaaacagaaa aagaagattt catcgaactc tgcacccctg gggtaattaa gcaagagaaa   1380

ctgggcacag tttactgtca ggcaagcttt cctggagcaa atataattgg taataaaatg   1440

tctgccattt ctgttcatgg tgtgagtacc tctggaggac agatgtacca ctatgacatg   1500

aatacagcat ccctttctca acagcaggat cagaagccta tttttaatgt cattccacca   1560

attcccgttg gttccgaaaa ttggaatagg tgccaaggat ctggagatga caacttgact   1620

tctctgggga ctctgaactt ccctggtcga acagtttttt ctaatggcta ttcaagcccc   1680

agcatgagac cagatgtaag ctctcctcca tccagctcct caacagcaac aacaggacca   1740

cctcccaaac tctgcctggt gtgctctgat gaagcttcag gatgtcatta tggagtctta   1800

acttgtggaa gctgtaaagt tttcttcaaa agagcagtgg aaggacagca caattaccta   1860

tgtgctggaa ggaatgattg catcatcgat aaaattcgaa gaaaaaactg cccagcatgc   1920

cgctatcgaa aatgtcttca ggctggaatg aacctggaag ctcgaaaaac aaagaaaaaa   1980

ataaaaggaa ttcagcaggc cactacagga gtctcacaag aaacctctga aaatcctggt   2040

aacaaaacaa tagttcctgc aacgttacca caactcaccc ctaccctggt gtcactgttg   2100

gaggttattg aacctgaagt gttatatgca ggatatgata gctctgttcc agactcaact   2160

tggaggatca tgactacgct caacatgtta ggagggcggc aagtgattgc agcagtgaaa   2220

tgggcaaagg caataccagg tttcaggaac ttacacctgg atgaccaaat gaccctactg   2280

cagtactcct ggatgtttct tatggcattt gctctggggt ggagatcata tagacaatca   2340

agtgcaaacc tgctgtgttt tgctcctgat ctgattatta atgagcagag aatgactcta   2400

ccctgcatgt acgaccaatg taaacacatg ctgtatgttt cctctgagtt acacaggctt   2460

caggtatctt atgaagagta tctctgtatg aaaaccttac tgcttctctc ttcagttcct   2520

aaggacggtc tgaagagcca agagctattt gatgaaatta gaatgaccta catcaaagag   2580

ctaggaaaag ccattgtcaa gagggaagga aactccagcc agaactggca gcggttttat   2640

caactgacaa aactcttgga ttctatgcat gaaaatgtta tgtggttaaa accagaaagc   2700

acatctcaca cattaatctg attttcatcc caacaatctt ggcgctcaaa aaatagaact   2760

caatgagaaa aagaagatta tgtgcacttc gttgtcaata ataagtcaac tgatgctcat   2820

cgacaactat aggaggcttt tcattaaatg ggaaaagaag ctgtgccctt ttaggatacg   2880

tgggggaaaa gaaagtcatc ttaattatgt ttaattgtgg atttaagtgc tatatggtgg   2940

tgctgtttga aagcagattt atttcctatg tatgtgttat ctggccatcc caacccaaac   3000

tgttgaagtt tgtagtaact tcagtgagag ttggttactc acaacaaatc ctgaaaagta   3060

tttttagtgt ttgtaggtat tctgtgggat actatacaag cagaactgag gcacttagga   3120

cataacactt ttggggtata tatatccaaa tgcctaaaac tatgggagga aaccttggcc   3180

accccaaaag gaaaactaac atgatttgtg tctatgaagt gctggataat tagcatggga   3240

tgagctctgg gcatgccatg aaggaaagcc acgctccctt cagaattcag aggcagggag   3300

caattccagt ttcacctaag tctcataatt ttagttccct tttaaaaacc ctgaaaacta   3360

catcaccatg gaatgaaaaa tattgttata caatacattg atctgtcaaa cttccagaac   3420

catggtagcc ttcagtgaga tttccatctt ggctggtcac tccctgactg tagctgtagg   3480

tgaatgtgtt tttgtgtgtg tgtgtctggt tttagtgtca gaagggaaat aaaagtgtaa   3540

ggaggacact ttaaaccctt tgggtggagt ttcgtaattt cccagactat tttcaagcaa   3600

cctggtccac ccaggattag tgaccaggtt ttcaggaaag gatttgcttc tctctagaaa   3660

atgtctgaaa ggattttatt ttctgatgaa aggctgtatg aaaataccct cctcaaataa   3720

cttgcttaac tacatataga ttcaagtgtg tcaatattct attttgtata ttaaatgcta   3780

tataatgggg acaaatctat attatactgt gtatggcatt attaagaagc tttttcatta   3840

ttttttatca cagtaatttt aaaatgtgta aaaattaaaa ccagtgactc ctgtttaaaa   3900

ataaaagttg tagtttttta ttcatgctga ataataatct gtagttaaaa aaaaagtgtc   3960

tttttaccta cgcagtgaaa tgtcagactg taaaaccttg tgtggaaatg tttaactttt   4020

attttttcat ttaaatttgc tgttctggta ttaccaaacc acacatttgt accgaattgg   4080

cagtaaatgt tagccattta cagcaatgcc aaatatggag aaacatcata ataaaaaaat   4140

ctgctttttc atta                                                     4154


<210>  294
<211>  742
<212>  PRT
<213>  Homo sapiens

<400>  294


Met Asp Ser Lys Glu Ser Leu Thr Pro Gly Arg Glu Glu Asn Pro Ser 
1               5                   10                  15      


Ser Val Leu Ala Gln Glu Arg Gly Asp Val Met Asp Phe Tyr Lys Thr 
            20                  25                  30          


Leu Arg Gly Gly Ala Thr Val Lys Val Ser Ala Ser Ser Pro Ser Leu 
        35                  40                  45              


Ala Val Ala Ser Gln Ser Asp Ser Lys Gln Arg Arg Leu Leu Val Asp 
    50                  55                  60                  


Phe Pro Lys Gly Ser Val Ser Asn Ala Gln Gln Pro Asp Leu Ser Lys 
65                  70                  75                  80  


Ala Val Ser Leu Ser Met Gly Leu Tyr Met Gly Glu Thr Glu Thr Lys 
                85                  90                  95      


Val Met Gly Asn Asp Leu Gly Phe Pro Gln Gln Gly Gln Ile Ser Leu 
            100                 105                 110         


Ser Ser Gly Glu Thr Asp Leu Lys Leu Leu Glu Glu Ser Ile Ala Asn 
        115                 120                 125             


Leu Asn Arg Ser Thr Ser Val Pro Glu Asn Pro Lys Ser Ser Ala Ser 
    130                 135                 140                 


Thr Ala Val Ser Ala Ala Pro Thr Glu Lys Glu Phe Pro Lys Thr His 
145                 150                 155                 160 


Ser Asp Val Ser Ser Glu Gln Gln His Leu Lys Gly Gln Thr Gly Thr 
                165                 170                 175     


Asn Gly Gly Asn Val Lys Leu Tyr Thr Thr Asp Gln Ser Thr Phe Asp 
            180                 185                 190         


Ile Leu Gln Asp Leu Glu Phe Ser Ser Gly Ser Pro Gly Lys Glu Thr 
        195                 200                 205             


Asn Glu Ser Pro Trp Arg Ser Asp Leu Leu Ile Asp Glu Asn Cys Leu 
    210                 215                 220                 


Leu Ser Pro Leu Ala Gly Glu Asp Asp Ser Phe Leu Leu Glu Gly Asn 
225                 230                 235                 240 


Ser Asn Glu Asp Cys Lys Pro Leu Ile Leu Pro Asp Thr Lys Pro Lys 
                245                 250                 255     


Ile Lys Asp Asn Gly Asp Leu Val Leu Ser Ser Pro Ser Asn Val Thr 
            260                 265                 270         


Leu Pro Gln Val Lys Thr Glu Lys Glu Asp Phe Ile Glu Leu Cys Thr 
        275                 280                 285             


Pro Gly Val Ile Lys Gln Glu Lys Leu Gly Thr Val Tyr Cys Gln Ala 
    290                 295                 300                 


Ser Phe Pro Gly Ala Asn Ile Ile Gly Asn Lys Met Ser Ala Ile Ser 
305                 310                 315                 320 


Val His Gly Val Ser Thr Ser Gly Gly Gln Met Tyr His Tyr Asp Met 
                325                 330                 335     


Asn Thr Ala Ser Leu Ser Gln Gln Gln Asp Gln Lys Pro Ile Phe Asn 
            340                 345                 350         


Val Ile Pro Pro Ile Pro Val Gly Ser Glu Asn Trp Asn Arg Cys Gln 
        355                 360                 365             


Gly Ser Gly Asp Asp Asn Leu Thr Ser Leu Gly Thr Leu Asn Phe Pro 
    370                 375                 380                 


Gly Arg Thr Val Phe Ser Asn Gly Tyr Ser Ser Pro Ser Met Arg Pro 
385                 390                 395                 400 


Asp Val Ser Ser Pro Pro Ser Ser Ser Ser Thr Ala Thr Thr Gly Pro 
                405                 410                 415     


Pro Pro Lys Leu Cys Leu Val Cys Ser Asp Glu Ala Ser Gly Cys His 
            420                 425                 430         


Tyr Gly Val Leu Thr Cys Gly Ser Cys Lys Val Phe Phe Lys Arg Ala 
        435                 440                 445             


Val Glu Gly Gln His Asn Tyr Leu Cys Ala Gly Arg Asn Asp Cys Ile 
    450                 455                 460                 


Ile Asp Lys Ile Arg Arg Lys Asn Cys Pro Ala Cys Arg Tyr Arg Lys 
465                 470                 475                 480 


Cys Leu Gln Ala Gly Met Asn Leu Glu Ala Arg Lys Thr Lys Lys Lys 
                485                 490                 495     


Ile Lys Gly Ile Gln Gln Ala Thr Thr Gly Val Ser Gln Glu Thr Ser 
            500                 505                 510         


Glu Asn Pro Gly Asn Lys Thr Ile Val Pro Ala Thr Leu Pro Gln Leu 
        515                 520                 525             


Thr Pro Thr Leu Val Ser Leu Leu Glu Val Ile Glu Pro Glu Val Leu 
    530                 535                 540                 


Tyr Ala Gly Tyr Asp Ser Ser Val Pro Asp Ser Thr Trp Arg Ile Met 
545                 550                 555                 560 


Thr Thr Leu Asn Met Leu Gly Gly Arg Gln Val Ile Ala Ala Val Lys 
                565                 570                 575     


Trp Ala Lys Ala Ile Pro Gly Phe Arg Asn Leu His Leu Asp Asp Gln 
            580                 585                 590         


Met Thr Leu Leu Gln Tyr Ser Trp Met Phe Leu Met Ala Phe Ala Leu 
        595                 600                 605             


Gly Trp Arg Ser Tyr Arg Gln Ser Ser Ala Asn Leu Leu Cys Phe Ala 
    610                 615                 620                 


Pro Asp Leu Ile Ile Asn Glu Gln Arg Met Thr Leu Pro Cys Met Tyr 
625                 630                 635                 640 


Asp Gln Cys Lys His Met Leu Tyr Val Ser Ser Glu Leu His Arg Leu 
                645                 650                 655     


Gln Val Ser Tyr Glu Glu Tyr Leu Cys Met Lys Thr Leu Leu Leu Leu 
            660                 665                 670         


Ser Ser Val Pro Lys Asp Gly Leu Lys Ser Gln Glu Leu Phe Asp Glu 
        675                 680                 685             


Ile Arg Met Thr Tyr Ile Lys Glu Leu Gly Lys Ala Ile Val Lys Arg 
    690                 695                 700                 


Glu Gly Asn Ser Ser Gln Asn Trp Gln Arg Phe Tyr Gln Leu Thr Lys 
705                 710                 715                 720 


Leu Leu Asp Ser Met His Glu Asn Val Met Trp Leu Lys Pro Glu Ser 
                725                 730                 735     


Thr Ser His Thr Leu Ile 
            740         

<210>  295
<211>  6787
<212>  DNA
<213>  Homo sapiens

<400>  295
ggcgccgcct ccacccgctc cccgctcggt cccgctcgct cgcccaggcc gggctgccct     60

ttcgcgtgtc cgcgctctct tccctccgcc gccgcctcct ccattttgcg agctcgtgtc    120

tgtgacggga gcccgagtca ccgcctgccc gtcggggacg gattctgtgg gtggaaggag    180

acgccgcagc cggagcggcc gaagcagctg ggaccgggac ggggcacgcg cgcccggaac    240

ctcgacccgc ggagcccggc gcggggcgga gggctggctt gtcagctggg caatgggaga    300

ctttcttaaa taggggctct ccccccaccc atggagaaag gggcggctgt ttacttcctt    360

tttttagaaa aaaaaaatat atttccctcc tgctccttct gcgttcacaa gctaagttgt    420

ttatctcggc tgcggcggga actgcggacg gtggcgggcg agcggctcct ctgccagagt    480

tgatattcac tgatggactc caaagaatca ttaactcctg gtagagaaga aaaccccagc    540

agtgtgcttg ctcaggagag gggagatgtg atggacttct ataaaaccct aagaggagga    600

gctactgtga aggtttctgc gtcttcaccc tcactggctg tcgcttctca atcagactcc    660

aagcagcgaa gacttttggt tgattttcca aaaggctcag taagcaatgc gcagcagcca    720

gatctgtcca aagcagtttc actctcaatg ggactgtata tgggagagac agaaacaaaa    780

gtgatgggaa atgacctggg attcccacag cagggccaaa tcagcctttc ctcgggggaa    840

acagacttaa agcttttgga agaaagcatt gcaaacctca ataggtcgac cagtgttcca    900

gagaacccca agagttcagc atccactgct gtgtctgctg cccccacaga gaaggagttt    960

ccaaaaactc actctgatgt atcttcagaa cagcaacatt tgaagggcca gactggcacc   1020

aacggtggca atgtgaaatt gtataccaca gaccaaagca cctttgacat tttgcaggat   1080

ttggagtttt cttctgggtc cccaggtaaa gagacgaatg agagtccttg gagatcagac   1140

ctgttgatag atgaaaactg tttgctttct cctctggcgg gagaagacga ttcattcctt   1200

ttggaaggaa actcgaatga ggactgcaag cctctcattt taccggacac taaacccaaa   1260

attaaggata atggagatct ggttttgtca agccccagta atgtaacact gccccaagtg   1320

aaaacagaaa aagaagattt catcgaactc tgcacccctg gggtaattaa gcaagagaaa   1380

ctgggcacag tttactgtca ggcaagcttt cctggagcaa atataattgg taataaaatg   1440

tctgccattt ctgttcatgg tgtgagtacc tctggaggac agatgtacca ctatgacatg   1500

aatacagcat ccctttctca acagcaggat cagaagccta tttttaatgt cattccacca   1560

attcccgttg gttccgaaaa ttggaatagg tgccaaggat ctggagatga caacttgact   1620

tctctgggga ctctgaactt ccctggtcga acagtttttt ctaatggcta ttcaagcccc   1680

agcatgagac cagatgtaag ctctcctcca tccagctcct caacagcaac aacaggacca   1740

cctcccaaac tctgcctggt gtgctctgat gaagcttcag gatgtcatta tggagtctta   1800

acttgtggaa gctgtaaagt tttcttcaaa agagcagtgg aaggtagaca gcacaattac   1860

ctatgtgctg gaaggaatga ttgcatcatc gataaaattc gaagaaaaaa ctgcccagca   1920

tgccgctatc gaaaatgtct tcaggctgga atgaacctgg aagctcgaaa aacaaagaaa   1980

aaaataaaag gaattcagca ggccactaca ggagtctcac aagaaacctc tgaaaatcct   2040

ggtaacaaaa caatagttcc tgcaacgtta ccacaactca cccctaccct ggtgtcactg   2100

ttggaggtta ttgaacctga agtgttatat gcaggatatg atagctctgt tccagactca   2160

acttggagga tcatgactac gctcaacatg ttaggagggc ggcaagtgat tgcagcagtg   2220

aaatgggcaa aggcaatacc aggtttcagg aacttacacc tggatgacca aatgacccta   2280

ctgcagtact cctggatgtt tcttatggca tttgctctgg ggtggagatc atatagacaa   2340

tcaagtgcaa acctgctgtg ttttgctcct gatctgatta ttaatgagca gagaatgact   2400

ctaccctgca tgtacgacca atgtaaacac atgctgtatg tttcctctga gttacacagg   2460

cttcaggtat cttatgaaga gtatctctgt atgaaaacct tactgcttct ctcttcagtt   2520

cctaaggacg gtctgaagag ccaagagcta tttgatgaaa ttagaatgac ctacatcaaa   2580

gagctaggaa aagccattgt caagagggaa ggaaactcca gccagaactg gcagcggttt   2640

tatcaactga caaaactctt ggattctatg catgaagtgg ttgaaaatct ccttaactat   2700

tgcttccaaa catttttgga taagaccatg agtattgaat tccccgagat gttagctgaa   2760

atcatcacca atcagatacc aaaatattca aatggaaata tcaaaaaact tctgtttcat   2820

caaaagtgac tgccttaata agaatggttg ccttaaagaa agtcgaatta atagctttta   2880

ttgtataaac tatcagtttg tcctgtagag gttttgttgt tttatttttt attgttttca   2940

tctgttgttt tgttttaaat acgcactaca tgtggtttat agagggccaa gacttggcaa   3000

cagaagcagt tgagtcgtca tcacttttca gtgatgggag agtagatggt gaaatttatt   3060

agttaatata tcccagaaat tagaaacctt aatatgtgga cgtaatctcc acagtcaaag   3120

aaggatggca cctaaaccac cagtgcccaa agtctgtgtg atgaactttc tcttcatact   3180

ttttttcaca gttggctgga tgaaattttc tagactttct gttggtgtat cccccccctg   3240

tatagttagg atagcatttt tgatttatgc atggaaacct gaaaaaaagt ttacaagtgt   3300

atatcagaaa agggaagttg tgccttttat agctattact gtctggtttt aacaatttcc   3360

tttatattta gtgaactacg cttgctcatt ttttcttaca taatttttta ttcaagttat   3420

tgtacagctg tttaagatgg gcagctagtt cgtagctttc ccaaataaac tctaaacatt   3480

aatcaatcat ctgtgtgaaa atgggttggt gcttctaacc tgatggcact tagctatcag   3540

aagaccacaa aaattgactc aaatctccag tattcttgtc aaaaaaaaaa aaaaaaaagc   3600

tcatattttg tatatatctg cttcagtgga gaattatata ggttgtgcaa attaacagtc   3660

ctaactggta tagagcacct agtccagtga cctgctgggt aaactgtgga tgatggttgc   3720

aaaagactaa tttaaaaaat aactaccaag aggccctgtc tgtacctaac gccctatttt   3780

tgcaatggct atatggcaag aaagctggta aactatttgt ctttcaggac cttttgaagt   3840

agtttgtata acttcttaaa agttgtgatt ccagataacc agctgtaaca cagctgagag   3900

acttttaatc agacaaagta attcctctca ctaaacttta cccaaaaact aaatctctaa   3960

tatggcaaaa atggctagac acccattttc acattcccat ctgtcaccaa ttggttaatc   4020

tttcctgatg gtacaggaaa gctcagctac tgatttttgt gatttagaac tgtatgtcag   4080

acatccatgt ttgtaaaact acacatccct aatgtgtgcc atagagttta acacaagtcc   4140

tgtgaatttc ttcactgttg aaaattattt taaacaaaat agaagctgta gtagcccttt   4200

ctgtgtgcac cttaccaact ttctgtaaac tcaaaactta acatatttac taagccacaa   4260

gaaatttgat ttctattcaa ggtggccaaa ttatttgtgt aatagaaaac tgaaaatcta   4320

atattaaaaa tatggaactt ctaatatatt tttatattta gttatagttt cagatatata   4380

tcatattggt attcactaat ctgggaaggg aagggctact gcagctttac atgcaattta   4440

ttaaaatgat tgtaaaatag cttgtatagt gtaaaataag aatgattttt agatgagatt   4500

gttttatcat gacatgttat atattttttg taggggtcaa agaaatgctg atggataacc   4560

tatatgattt atagtttgta catgcattca tacaggcagc gatggtctca gaaaccaaac   4620

agtttgctct aggggaagag ggagatggag actggtcctg tgtgcagtga aggttgctga   4680

ggctctgacc cagtgagatt acagaggaag ttatcctctg cctcccattc tgaccaccct   4740

tctcattcca acagtgagtc tgtcagcgca ggtttagttt actcaatctc cccttgcact   4800

aaagtatgta aagtatgtaa acaggagaca ggaaggtggt gcttacatcc ttaaaggcac   4860

catctaatag cgggttactt tcacatacag ccctccccca gcagttgaat gacaacagaa   4920

gcttcagaag tttggcaata gtttgcatag aggtaccagc aatatgtaaa tagtgcagaa   4980

tctcataggt tgccaataat acactaattc ctttctatcc tacaacaaga gtttatttcc   5040

aaataaaatg aggacatgtt tttgttttct ttgaatgctt tttgaatgtt atttgttatt   5100

ttcagtattt tggagaaatt atttaataaa aaaacaatca tttgcttttt gaatgctctc   5160

taaaagggaa tgtaatattt taagatggtg tgtaacccgg ctggataaat ttttggtgcc   5220

taagaaaact gcttgaatat tcttatcaat gacagtgtta agtttcaaaa agagcttcta   5280

aaacgtagat tatcattcct ttatagaatg ttatgtggtt aaaaccagaa agcacatctc   5340

acacattaat ctgattttca tcccaacaat cttggcgctc aaaaaataga actcaatgag   5400

aaaaagaaga ttatgtgcac ttcgttgtca ataataagtc aactgatgct catcgacaac   5460

tataggaggc ttttcattaa atgggaaaag aagctgtgcc cttttaggat acgtggggga   5520

aaagaaagtc atcttaatta tgtttaattg tggatttaag tgctatatgg tggtgctgtt   5580

tgaaagcaga tttatttcct atgtatgtgt tatctggcca tcccaaccca aactgttgaa   5640

gtttgtagta acttcagtga gagttggtta ctcacaacaa atcctgaaaa gtatttttag   5700

tgtttgtagg tattctgtgg gatactatac aagcagaact gaggcactta ggacataaca   5760

cttttggggt atatatatcc aaatgcctaa aactatggga ggaaaccttg gccaccccaa   5820

aaggaaaact aacatgattt gtgtctatga agtgctggat aattagcatg ggatgagctc   5880

tgggcatgcc atgaaggaaa gccacgctcc cttcagaatt cagaggcagg gagcaattcc   5940

agtttcacct aagtctcata attttagttc ccttttaaaa accctgaaaa ctacatcacc   6000

atggaatgaa aaatattgtt atacaataca ttgatctgtc aaacttccag aaccatggta   6060

gccttcagtg agatttccat cttggctggt cactccctga ctgtagctgt aggtgaatgt   6120

gtttttgtgt gtgtgtgtct ggttttagtg tcagaaggga aataaaagtg taaggaggac   6180

actttaaacc ctttgggtgg agtttcgtaa tttcccagac tattttcaag caacctggtc   6240

cacccaggat tagtgaccag gttttcagga aaggatttgc ttctctctag aaaatgtctg   6300

aaaggatttt attttctgat gaaaggctgt atgaaaatac cctcctcaaa taacttgctt   6360

aactacatat agattcaagt gtgtcaatat tctattttgt atattaaatg ctatataatg   6420

gggacaaatc tatattatac tgtgtatggc attattaaga agctttttca ttatttttta   6480

tcacagtaat tttaaaatgt gtaaaaatta aaaccagtga ctcctgttta aaaataaaag   6540

ttgtagtttt ttattcatgc tgaataataa tctgtagtta aaaaaaaagt gtctttttac   6600

ctacgcagtg aaatgtcaga ctgtaaaacc ttgtgtggaa atgtttaact tttatttttt   6660

catttaaatt tgctgttctg gtattaccaa accacacatt tgtaccgaat tggcagtaaa   6720

tgttagccat ttacagcaat gccaaatatg gagaaacatc ataataaaaa aatctgcttt   6780

ttcatta                                                             6787


<210>  296
<211>  778
<212>  PRT
<213>  Homo sapiens

<400>  296


Met Asp Ser Lys Glu Ser Leu Thr Pro Gly Arg Glu Glu Asn Pro Ser 
1               5                   10                  15      


Ser Val Leu Ala Gln Glu Arg Gly Asp Val Met Asp Phe Tyr Lys Thr 
            20                  25                  30          


Leu Arg Gly Gly Ala Thr Val Lys Val Ser Ala Ser Ser Pro Ser Leu 
        35                  40                  45              


Ala Val Ala Ser Gln Ser Asp Ser Lys Gln Arg Arg Leu Leu Val Asp 
    50                  55                  60                  


Phe Pro Lys Gly Ser Val Ser Asn Ala Gln Gln Pro Asp Leu Ser Lys 
65                  70                  75                  80  


Ala Val Ser Leu Ser Met Gly Leu Tyr Met Gly Glu Thr Glu Thr Lys 
                85                  90                  95      


Val Met Gly Asn Asp Leu Gly Phe Pro Gln Gln Gly Gln Ile Ser Leu 
            100                 105                 110         


Ser Ser Gly Glu Thr Asp Leu Lys Leu Leu Glu Glu Ser Ile Ala Asn 
        115                 120                 125             


Leu Asn Arg Ser Thr Ser Val Pro Glu Asn Pro Lys Ser Ser Ala Ser 
    130                 135                 140                 


Thr Ala Val Ser Ala Ala Pro Thr Glu Lys Glu Phe Pro Lys Thr His 
145                 150                 155                 160 


Ser Asp Val Ser Ser Glu Gln Gln His Leu Lys Gly Gln Thr Gly Thr 
                165                 170                 175     


Asn Gly Gly Asn Val Lys Leu Tyr Thr Thr Asp Gln Ser Thr Phe Asp 
            180                 185                 190         


Ile Leu Gln Asp Leu Glu Phe Ser Ser Gly Ser Pro Gly Lys Glu Thr 
        195                 200                 205             


Asn Glu Ser Pro Trp Arg Ser Asp Leu Leu Ile Asp Glu Asn Cys Leu 
    210                 215                 220                 


Leu Ser Pro Leu Ala Gly Glu Asp Asp Ser Phe Leu Leu Glu Gly Asn 
225                 230                 235                 240 


Ser Asn Glu Asp Cys Lys Pro Leu Ile Leu Pro Asp Thr Lys Pro Lys 
                245                 250                 255     


Ile Lys Asp Asn Gly Asp Leu Val Leu Ser Ser Pro Ser Asn Val Thr 
            260                 265                 270         


Leu Pro Gln Val Lys Thr Glu Lys Glu Asp Phe Ile Glu Leu Cys Thr 
        275                 280                 285             


Pro Gly Val Ile Lys Gln Glu Lys Leu Gly Thr Val Tyr Cys Gln Ala 
    290                 295                 300                 


Ser Phe Pro Gly Ala Asn Ile Ile Gly Asn Lys Met Ser Ala Ile Ser 
305                 310                 315                 320 


Val His Gly Val Ser Thr Ser Gly Gly Gln Met Tyr His Tyr Asp Met 
                325                 330                 335     


Asn Thr Ala Ser Leu Ser Gln Gln Gln Asp Gln Lys Pro Ile Phe Asn 
            340                 345                 350         


Val Ile Pro Pro Ile Pro Val Gly Ser Glu Asn Trp Asn Arg Cys Gln 
        355                 360                 365             


Gly Ser Gly Asp Asp Asn Leu Thr Ser Leu Gly Thr Leu Asn Phe Pro 
    370                 375                 380                 


Gly Arg Thr Val Phe Ser Asn Gly Tyr Ser Ser Pro Ser Met Arg Pro 
385                 390                 395                 400 


Asp Val Ser Ser Pro Pro Ser Ser Ser Ser Thr Ala Thr Thr Gly Pro 
                405                 410                 415     


Pro Pro Lys Leu Cys Leu Val Cys Ser Asp Glu Ala Ser Gly Cys His 
            420                 425                 430         


Tyr Gly Val Leu Thr Cys Gly Ser Cys Lys Val Phe Phe Lys Arg Ala 
        435                 440                 445             


Val Glu Gly Arg Gln His Asn Tyr Leu Cys Ala Gly Arg Asn Asp Cys 
    450                 455                 460                 


Ile Ile Asp Lys Ile Arg Arg Lys Asn Cys Pro Ala Cys Arg Tyr Arg 
465                 470                 475                 480 


Lys Cys Leu Gln Ala Gly Met Asn Leu Glu Ala Arg Lys Thr Lys Lys 
                485                 490                 495     


Lys Ile Lys Gly Ile Gln Gln Ala Thr Thr Gly Val Ser Gln Glu Thr 
            500                 505                 510         


Ser Glu Asn Pro Gly Asn Lys Thr Ile Val Pro Ala Thr Leu Pro Gln 
        515                 520                 525             


Leu Thr Pro Thr Leu Val Ser Leu Leu Glu Val Ile Glu Pro Glu Val 
    530                 535                 540                 


Leu Tyr Ala Gly Tyr Asp Ser Ser Val Pro Asp Ser Thr Trp Arg Ile 
545                 550                 555                 560 


Met Thr Thr Leu Asn Met Leu Gly Gly Arg Gln Val Ile Ala Ala Val 
                565                 570                 575     


Lys Trp Ala Lys Ala Ile Pro Gly Phe Arg Asn Leu His Leu Asp Asp 
            580                 585                 590         


Gln Met Thr Leu Leu Gln Tyr Ser Trp Met Phe Leu Met Ala Phe Ala 
        595                 600                 605             


Leu Gly Trp Arg Ser Tyr Arg Gln Ser Ser Ala Asn Leu Leu Cys Phe 
    610                 615                 620                 


Ala Pro Asp Leu Ile Ile Asn Glu Gln Arg Met Thr Leu Pro Cys Met 
625                 630                 635                 640 


Tyr Asp Gln Cys Lys His Met Leu Tyr Val Ser Ser Glu Leu His Arg 
                645                 650                 655     


Leu Gln Val Ser Tyr Glu Glu Tyr Leu Cys Met Lys Thr Leu Leu Leu 
            660                 665                 670         


Leu Ser Ser Val Pro Lys Asp Gly Leu Lys Ser Gln Glu Leu Phe Asp 
        675                 680                 685             


Glu Ile Arg Met Thr Tyr Ile Lys Glu Leu Gly Lys Ala Ile Val Lys 
    690                 695                 700                 


Arg Glu Gly Asn Ser Ser Gln Asn Trp Gln Arg Phe Tyr Gln Leu Thr 
705                 710                 715                 720 


Lys Leu Leu Asp Ser Met His Glu Val Val Glu Asn Leu Leu Asn Tyr 
                725                 730                 735     


Cys Phe Gln Thr Phe Leu Asp Lys Thr Met Ser Ile Glu Phe Pro Glu 
            740                 745                 750         


Met Leu Ala Glu Ile Ile Thr Asn Gln Ile Pro Lys Tyr Ser Asn Gly 
        755                 760                 765             


Asn Ile Lys Lys Leu Leu Phe His Gln Lys 
    770                 775             

<210>  297
<211>  266
<212>  DNA
<213>  Homo sapiens

<400>  297
accaaaccca tcagaagttt gcaggacgtc cttgtttaga gctgggaaat aaaccacgaa     60

acagcgcaaa ggagagtcca ggcctgccaa tgcttccgcg aactcctcgc cccgacctca    120

tccttctcca gctcctacct gcaggcctca ggcctcctga cctccaggct ccttaccctc    180

ccgctggcct ctgctctaca ctcatctttg tgccctgctt ccaatcatgc caggcctcgg    240

ggtccctgtc tctaacttca ccatga                                         266


<210>  298
<211>  1546
<212>  DNA
<213>  Homo sapiens

<400>  298
agttcctacc cgcgagaggg aagaagcagg aggtctcagc atgaaacagc agcagtggtg     60

tgggatgact gccaaaatgg gcaccgtgtt gtcaggggtc ttcaccatca tggccgtaga    120

catgtatctc atctttgaac agaagcacct agggaatggc agttgcactg agatcacacc    180

aaagtacagg ggtgcaagta acatcataaa taacttcatc atctgctgga gttttaaaat    240

cgtcctcttc ctgtctttca tcaccatcct catcagctgc ttcctcctgt actcagtgta    300

tgcccagatc ttcaggggcc tggtcatcta cattgtctgg atttttttct atgaaactgc    360

aaacgtcgta atacaaatcc tcaccaacaa tgactttgac attaaagagg tcagaatcat    420

gcgctggttt ggcttggtgt ctcgtacagt catgcactgt ttctggatgt tctttgtcat    480

caactatgcc cacataacct acaaaaaccg gagccagggc aatataattt cctacaagag    540

acgaatttct acagcggaga ttctccacag cagaaataaa agattatcaa tttcgagtgg    600

gttcagtggc tcacacctgg aatcccagta ctttgagagg cagagcttcc acactagcat    660

atttacctgt ctgtctccag tgccaagctc agcccccagc acctgtagat acacaataga    720

tgtctgctga gaggtgctct ggtaaaacaa gtataaaatg aatgtcagga tgttctccct    780

catggtgggc atcttctctg tccttaatac cacccagttc ttcatctttg acctgaacca    840

gaagacacac atttgctatg aggccaagtt cagcatctac gtggactcaa agtcggagct    900

agtcacttgg accctgttcc acagggctaa tatcagcact ggcctctccc tcaccaccat    960

catcatcggc tgcttcctcc tttattgtat ccacaagaat atctacatgg ggctgctgat   1020

ctatgccatg tggatcatca cttacgagct catcaacttc tccatagtcc tgctcctcaa   1080

cgggatcatc aaagatcact tcaagacgct gagttatttg cactggatct tccaaatctc   1140

acacatgttc ctgcactttt tctgtctgcc cttcatcgtc aagcatgcat acaaccttta   1200

caaggaatcc cagactgtgg gcaggaaacg ccgccacagg ctctgctcca ccattgcagt   1260

gaacttatga ctacctgtcc gtctgggaat gttgtaccgg aagttaaact gaaccatgcc   1320

agatgccagg aaaggtggga gggaatggtg ttcctcaaca atggaaccct ccctaccctg   1380

cctgtcttct gttgatgctg cttggtttgt cagggctttt gagttttacg cactgaggaa   1440

tgattctcgg gagagggcag gttgtgcgga tcaattattt tacagatgtg ttgtgtgact   1500

tgttttagca gttaatgata tgtggccttg tgcttactta accatc                  1546


<210>  299
<211>  229
<212>  PRT
<213>  Homo sapiens

<400>  299


Met Lys Gln Gln Gln Trp Cys Gly Met Thr Ala Lys Met Gly Thr Val 
1               5                   10                  15      


Leu Ser Gly Val Phe Thr Ile Met Ala Val Asp Met Tyr Leu Ile Phe 
            20                  25                  30          


Glu Gln Lys His Leu Gly Asn Gly Ser Cys Thr Glu Ile Thr Pro Lys 
        35                  40                  45              


Tyr Arg Gly Ala Ser Asn Ile Ile Asn Asn Phe Ile Ile Cys Trp Ser 
    50                  55                  60                  


Phe Lys Ile Val Leu Phe Leu Ser Phe Ile Thr Ile Leu Ile Ser Cys 
65                  70                  75                  80  


Phe Leu Leu Tyr Ser Val Tyr Ala Gln Ile Phe Arg Gly Leu Val Ile 
                85                  90                  95      


Tyr Ile Val Trp Ile Phe Phe Tyr Glu Thr Ala Asn Val Val Ile Gln 
            100                 105                 110         


Ile Leu Thr Asn Asn Asp Phe Asp Ile Lys Glu Val Arg Ile Met Arg 
        115                 120                 125             


Trp Phe Gly Leu Val Ser Arg Thr Val Met His Cys Phe Trp Met Phe 
    130                 135                 140                 


Phe Val Ile Asn Tyr Ala His Ile Thr Tyr Lys Asn Arg Ser Gln Gly 
145                 150                 155                 160 


Asn Ile Ile Ser Tyr Lys Arg Arg Ile Ser Thr Ala Glu Ile Leu His 
                165                 170                 175     


Ser Arg Asn Lys Arg Leu Ser Ile Ser Ser Gly Phe Ser Gly Ser His 
            180                 185                 190         


Leu Glu Ser Gln Tyr Phe Glu Arg Gln Ser Phe His Thr Ser Ile Phe 
        195                 200                 205             


Thr Cys Leu Ser Pro Val Pro Ser Ser Ala Pro Ser Thr Cys Arg Tyr 
    210                 215                 220                 


Thr Ile Asp Val Cys 
225                 

<210>  300
<211>  3477
<212>  DNA
<213>  Homo sapiens

<400>  300
acatccaaga tggcgtcccc aggagctggg agcgggtgac cggcggcggg gaagcggcct     60

gggttggccc tcagattgcg gggtctgggg gcatctcgcc gggcaaaccc ttggcccgcc    120

tacaaggact tcccccggcc agagcaatgg ccgctgagaa cagcaagcag ttttggaaga    180

ggagcgctaa gctgccgggg agcattcagc ctgtatatgg agcacagcat cctcctcttg    240

acccacggct caccaaaaat ttcattaaag aacgatcaaa agtcaacaca gttcctctga    300

agaataagaa ggcctccagt tttcatgagt ttgcacggaa taccagtgat gcttgggaca    360

ttggcgatga tgaggaagag gacttttcct caccttcttt ccaaactctg aactcaaaag    420

ttgctttggc aactgcagcc caagttctag aaaaccacag caagctgaga gtaaaaccag    480

aacggtccca gtcaacgaca tcggacgtcc ctgccaacta caaggtcata aagtccagca    540

gtgatgccca gctgtccaga aactctagtg atacatgcct gaggaaccca ctccacaaac    600

agcaatcact ccctctccgg cccatcatcc ccctcgttgc ccggatctcg gatcagaacg    660

cttctggggc ccccccaatg actgtccggg agaaaacccg cctagaaaaa ttccgtcagc    720

ttctctccag ccagaacact gacttagatg aactgaggaa gtgtagctgg ccaggggttc    780

ccagggaggt tcgacctata acctggagac tcctgtcggg ctatctccca gcaaacactg    840

agaggaggaa gttgaccctg cagcggaagc gggaggaata ttttggcttc attgaacagt    900

attatgactc tcgaaacgag gaacatcacc aggataccta cagacagatt cacattgaca    960

ttccaaggac gaatcctctc attccgttgt tccagcaacc acttgtacag gagatctttg   1020

aaagaattct atttatttgg gccatccgcc accctgccag tgggtatgtc cagggaatta   1080

atgacctggt cactccattc tttgtcgtct tcctctcaga atatgtggaa gaggatgtgg   1140

agaactttga cgtgaccaac ttgtctcaag acatgctgcg aagcattgag gctgacagct   1200

tttggtgcat gagcaagctg ctggatggaa tccaggataa ctacaccttt gcacaaccag   1260

gaatccagaa gaaggtgaag gcactggaag agcttgtcag ccggattgat gagcaggtac   1320

ataatcactt caggaggtac gaggtagaat acctgcagtt tgccttccgc tggatgaaca   1380

acctgcttat gcgggagctt cctcttcgct gcaccatccg cctgtgggac acatatcagt   1440

ctgaaccaga agggttctcc cactttcatc tctacgtgtg tgcagccttc ttgatcaagt   1500

ggaggaaaga gatcttggat gaggaggatt ttcagggtct cctcatgctg ctacagaacc   1560

tacctacaat acactggggc aacgaagaaa ttgggctgct tctcgccgag gcatacagac   1620

tcaagtacat gtttgccgat gccccaaatc actaccgccg ataggtgctg tctcctccgg   1680

ggacccagac tgccttcatc tctgatggca gtctgatcac tgtggccact gtgcgagccg   1740

tggaccccgg ccaggaacca ctcctgttgt acaaagctca cacccaccgc ccaggtctta   1800

actttctggc atccaccact ccatgtctct ggatgtgtca cttggaccac tgtcagtatt   1860

ccatgccgcg tggatgggcc cagttctggg agaggacaga aaaggtggta cagggttgtc   1920

tgccccttta aaagaaactg gacaaagaag gggaaggctc agggtctcac ctcacattgt   1980

ccctacaagg acaggcccca actgataacc gttgcttttt tttttttgtg aacatagttt   2040

gatttgatca caggtcaaaa acgccttata ttttcgaaag actcctggcc cctcttccct   2100

cttcctggtt tcctagccgt tccccttctg ccccagtctg agccagtgag gggtagcttt   2160

ttaaaaccat tattctagat ggaggaggca ctgatgcttg taactctgga aagaggccta   2220

cacccaaggg ctaggaattt tatttttcct tttctcacca ggtgtctgca tgtgtgtgtg   2280

ggtgtgaatg tgtatacatg cccatcagca tttagtcaca tgtctgaatt tctgtgtcca   2340

gacgagcccc atcaaactag ttgggaaggg ccccagtgac caagtgtata agcatccctt   2400

gaagagggat tggggcaggg gaggcagaag gggctctcca gacccctttt ccatgatgac   2460

ccactccaag atattatgtg taaattgtgt tattatgtat atgggtaaag atgtacaaat   2520

atatgtcctc tttgtagcag atatgatttt atatttataa tgtgcatcaa catgtgaaag   2580

caatctaggt cactagcaca gaggaagttg ccaggaaggt ggcttcagca cctccaggtt   2640

ggttctgggt gtcctgctgt gaggggtaga acgggaggct gctgaagtga gtagctgagc   2700

agctggagcc atcccaagca tcagtgtctc agagtcctcc tcgccccttt cttcaccccg   2760

ccccccaacc cccagacttt cctggagcat ctgccctttg ctcctagcag cctccccagg   2820

aagggactgc agaggcgggc aagccctctc tatgtgtttt tatccccacc ttccccggaa   2880

tctggggagg gcttttgttt ttacgttttc aagttcagca ttgtattcgg acagaagctg   2940

tgactgaaga ctcagtgcca aggaaagggg cttcttgtgt gtccctcggg tttggggctc   3000

ttctcagaga gcagcactcc atatccctta ctgtcacctt cactccccac acagctcatg   3060

agatgtgtga cccctgtttg agttttggta tttggtagtg gagggtgggg ggatgggggc   3120

cagcagctgt catcctcctg ggaagccgag cagtgtccct ggtgggtaac accctcaagt   3180

ctctttgcca gtgaggcccc accacatcgg tgtgagttag gtttctcatc tggagctgtt   3240

tctcaggcat tcttcccaac cctcttcctt ttccccttcg gtgtgcctca gtggtctcct   3300

tcatagagtg agagggcttg agaccctccc tcaaccggac taattaaaga aagacacttg   3360

tgttcccaag tggtggtttt atttttttag tttttatgtt tgtatgggaa attgtggata   3420

aagtgaaaag aattgtaaat aaatggtgta tttcctcctc caaaaaaaaa aaaaaaa      3477


<210>  301
<211>  505
<212>  PRT
<213>  Homo sapiens

<400>  301


Met Ala Ala Glu Asn Ser Lys Gln Phe Trp Lys Arg Ser Ala Lys Leu 
1               5                   10                  15      


Pro Gly Ser Ile Gln Pro Val Tyr Gly Ala Gln His Pro Pro Leu Asp 
            20                  25                  30          


Pro Arg Leu Thr Lys Asn Phe Ile Lys Glu Arg Ser Lys Val Asn Thr 
        35                  40                  45              


Val Pro Leu Lys Asn Lys Lys Ala Ser Ser Phe His Glu Phe Ala Arg 
    50                  55                  60                  


Asn Thr Ser Asp Ala Trp Asp Ile Gly Asp Asp Glu Glu Glu Asp Phe 
65                  70                  75                  80  


Ser Ser Pro Ser Phe Gln Thr Leu Asn Ser Lys Val Ala Leu Ala Thr 
                85                  90                  95      


Ala Ala Gln Val Leu Glu Asn His Ser Lys Leu Arg Val Lys Pro Glu 
            100                 105                 110         


Arg Ser Gln Ser Thr Thr Ser Asp Val Pro Ala Asn Tyr Lys Val Ile 
        115                 120                 125             


Lys Ser Ser Ser Asp Ala Gln Leu Ser Arg Asn Ser Ser Asp Thr Cys 
    130                 135                 140                 


Leu Arg Asn Pro Leu His Lys Gln Gln Ser Leu Pro Leu Arg Pro Ile 
145                 150                 155                 160 


Ile Pro Leu Val Ala Arg Ile Ser Asp Gln Asn Ala Ser Gly Ala Pro 
                165                 170                 175     


Pro Met Thr Val Arg Glu Lys Thr Arg Leu Glu Lys Phe Arg Gln Leu 
            180                 185                 190         


Leu Ser Ser Gln Asn Thr Asp Leu Asp Glu Leu Arg Lys Cys Ser Trp 
        195                 200                 205             


Pro Gly Val Pro Arg Glu Val Arg Pro Ile Thr Trp Arg Leu Leu Ser 
    210                 215                 220                 


Gly Tyr Leu Pro Ala Asn Thr Glu Arg Arg Lys Leu Thr Leu Gln Arg 
225                 230                 235                 240 


Lys Arg Glu Glu Tyr Phe Gly Phe Ile Glu Gln Tyr Tyr Asp Ser Arg 
                245                 250                 255     


Asn Glu Glu His His Gln Asp Thr Tyr Arg Gln Ile His Ile Asp Ile 
            260                 265                 270         


Pro Arg Thr Asn Pro Leu Ile Pro Leu Phe Gln Gln Pro Leu Val Gln 
        275                 280                 285             


Glu Ile Phe Glu Arg Ile Leu Phe Ile Trp Ala Ile Arg His Pro Ala 
    290                 295                 300                 


Ser Gly Tyr Val Gln Gly Ile Asn Asp Leu Val Thr Pro Phe Phe Val 
305                 310                 315                 320 


Val Phe Leu Ser Glu Tyr Val Glu Glu Asp Val Glu Asn Phe Asp Val 
                325                 330                 335     


Thr Asn Leu Ser Gln Asp Met Leu Arg Ser Ile Glu Ala Asp Ser Phe 
            340                 345                 350         


Trp Cys Met Ser Lys Leu Leu Asp Gly Ile Gln Asp Asn Tyr Thr Phe 
        355                 360                 365             


Ala Gln Pro Gly Ile Gln Lys Lys Val Lys Ala Leu Glu Glu Leu Val 
    370                 375                 380                 


Ser Arg Ile Asp Glu Gln Val His Asn His Phe Arg Arg Tyr Glu Val 
385                 390                 395                 400 


Glu Tyr Leu Gln Phe Ala Phe Arg Trp Met Asn Asn Leu Leu Met Arg 
                405                 410                 415     


Glu Leu Pro Leu Arg Cys Thr Ile Arg Leu Trp Asp Thr Tyr Gln Ser 
            420                 425                 430         


Glu Pro Glu Gly Phe Ser His Phe His Leu Tyr Val Cys Ala Ala Phe 
        435                 440                 445             


Leu Ile Lys Trp Arg Lys Glu Ile Leu Asp Glu Glu Asp Phe Gln Gly 
    450                 455                 460                 


Leu Leu Met Leu Leu Gln Asn Leu Pro Thr Ile His Trp Gly Asn Glu 
465                 470                 475                 480 


Glu Ile Gly Leu Leu Leu Ala Glu Ala Tyr Arg Leu Lys Tyr Met Phe 
                485                 490                 495     


Ala Asp Ala Pro Asn His Tyr Arg Arg 
            500                 505 

<210>  302
<211>  5639
<212>  DNA
<213>  Homo sapiens

<400>  302
cttgcgcagg cgtagtgctc ctgcttcctg gccgagggcg ggcgagcgga gcctgctttc     60

gcagcgatcg cgagcgtgtg gcgattgctt ctgtctgtta tttagatatg gaagctgagg    120

ggatgcacag aggcagccag aacctaggtc agggtctcgc tcggtgctga ccgcccccgg    180

ggtcgagtag gcgatggggg agcccggctt cttcgtcaca ggagaccgcg ccggtggccg    240

gagctggtgc ctgcggcggg tggggatgag cgccgggtgg ctgctgctgg aagatgggtg    300

cgaggtgact gtaggacgag gatttggtgt cacataccaa ctggtatcaa aaatctgccc    360

cctgatgatt tctcgaaacc actgtgtttt gaagcagaat cctgagggcc aatggacaat    420

tatggacaac aagagtctaa atggtgtttg gctgaacaga gcgcgtctgg aacctttaag    480

ggtctattcc attcatcagg gagactacat ccaacttgga gtgcctctgg aaaataagga    540

gaatgcggag tatgaatatg aagttactga agaagactgg gagacaatat atccttgtct    600

ttccccaaag aatgaccaaa tgatagaaaa aaataaggaa ttgagaacta aaaggaaatt    660

cagtttggat gaattagcag gtcctggagc tgaaggcccc tcaaatttga aatccaaaat    720

aaataaagtg tcttgtgaat ctggtcagcc agtgaaatca caggggaaag gtgaagtggc    780

cagtacaccc tctgacaatt tggatcctaa gttgactgcc cttgagccaa gtaagaccac    840

aggggctccc atttaccctg gcttccccaa agtcacagag gttcatcatg agcagaaagc    900

ctcaaactct tcagcatctc agagaagctt acagatgttt aaggtgacca tgtccaggat    960

tctgaggctc aaaatacaga tgcaggaaaa acatgaagcc gttatgaatg tgaaaaagca   1020

gacccaaaag gggaactcaa agaaagttgt gcaaatggag caggaacttc aggacttaca   1080

gtcccagctg tgtgcagagc aggctcagca gcaggcaaga gtggagcaac tagagaagac   1140

tttccaggaa gaggaacagc atcttcaggg tttggagata gcccaaggag aaaaggacct   1200

gaagcaacag ctggcccagg ctctgcagga gcattgggct ctaatggaag agctaaatcg   1260

cagcaagaag gactttgaag caatcattca agccaagaac aaagaattag agcagaccaa   1320

ggaagagaag gagaagatgc aagcacagaa ggaagaagtt cttagccaca tgaatgatgt   1380

gctagagaat gagctccaat gtattatttg ttcagaatac ttcattgagg ctgtcacctt   1440

gaactgtgcc cacagtttct gctcctactg tatcaatgaa tggatgaagc ggaagataga   1500

atgccccatt tgtcggaagg acattaagtc caaaacgtac tctttggttc tggacaattg   1560

cattaataag atggtaaata atctgagctc agaagtgaaa gaacgacgaa ttgttctcat   1620

tagggaacga aaagcaaaga gattgttctg aagaccgtgc tctaagggca tttgaaagac   1680

tgccaggtag tgcgagcctg agatggtctg gaggattctc tctagccgtg actccgctgc   1740

tctgaaggtc aactgagaag tcttgtggga cagagacttg agttaggaag ccctcagtca   1800

cttgccttcc acggtggcca gccctgctgc catcattggc tgaagcacca ccaggattca   1860

cggcacccaa ctgcttcagg gtacttcgta gactctgcct cactacatgt cgaaagagtt   1920

atttgagttc tcttctgttt ttttttaatt tgttgttgtt gttactgttt tgatacctcg   1980

gaaacacctc cgttgacagt tgttttggat aggttgggtg taccccatgg ctgcctctga   2040

aggcagtgtc tattttgaga ggatggctta cctcttcttt gtgaaaatac tatctcattt   2100

cctggaaata aaatgtaaaa cctgtcagtt gctcagctgg gctttggtgt atttaccttc   2160

cttcccttcc tgctcccaga cagtctcaca agtaaacacc agcagctcat agattacaac   2220

caagaaagtg actgtatcag atgatagact tcaagtgaat gtcagcctaa gaggccaagc   2280

tgcagatcgt ggcaacagat gagctctgtt aacctcctga ctgtcgtgtt tcctttttat   2340

tacagaggtg ggtcactgtt taccttgttt caggggtggg agaaactcct ttccttcagc   2400

tggcatttga atgtttccaa atctatttta tctgacgtca tgaacacaca ggcaatgatt   2460

ttatgacaac ttgatgtgct tttttcttta tttttctttt acattagaag ttttctctct   2520

tttctccacc tctcctttat ttttaatttt aattttaatt tttgaaacaa gatctgactc   2580

tgttgcccaa gctggagtac agtagtgcaa tctcagctca ctgcaacctc cacctcccag   2640

actcaagcca tcctcccacc tcaacctccc aagtagctgg gactacaggc atatgccatc   2700

acacccagct aatttttgtt tttctgtaga gacagggttt caccatgttg gccaggctgg   2760

tctcaaattc ctgaccttaa gtgatccacc tgcctaggcc tctaaaatgc tgggattaca   2820

ggcgtgagcc accacgccca gcctataccc catgtatttt cataaagggt tggaaactat   2880

tgattgccaa ctttttaagg atggtaggga ttttttcttt gttgaatata ctgtgaattt   2940

tgggattctg gagtccttag tcttcatttc cattcttctg cccatgatta ctgatcaaaa   3000

tactggtaga gtcatggagg aagtaagtta aatgtggaaa aaatgcttta aaagtactta   3060

ctataaccac atcataagaa ttctggaaaa atagagaaca aaaggaaaag attgttacca   3120

ccttgattta ataacttctt gtttccccat acatgtgttt tgtttataga ttgcatgggt   3180

atatgtcaat ttttatatgt tctgtgttta gtttacatat tgtaattcat ttttaagaga   3240

gtacagacat acactttttg agtaggcaat atgttcacat agtttgaaat taaaggtaca   3300

aaatggcgta gaatgaaatg cctctcaccc tttccccaca gcgactactt cccactcaga   3360

ggcaacaagt attacagttg cttgtatatt cttccagaga tctctgtcta tacaagcaaa   3420

aacacatgtg gtctttttcc ttgctttgca caaatggtaa actgtacgct attctgaacc   3480

ttgctttttt cagatatatg ttggcaacag ttccatgtca gtacatagtt tcctttcttt   3540

attacagctg cctgtttttt cattgtgtat ttgcaccatc atttactttt ctggcttact   3600

tttgatagaa atctaggttg gttcaaacct ttttactctt aaaacaatgc tgcagttaac   3660

acccttgtac atatatcttt agagagaaga tattttaaaa agaaatacct ttttaaaaat   3720

tattttatta ttttttaata gagactatgt tgcctaggct ggtcttgaaa ttctgggcta   3780

aagcaatcct accaccttgg cctcccaaag tgctgagatt acaggcatga gccattgcac   3840

ctggccaaga agagacatct tgacttgagc ctgaagacta tgtacagaga ctgacctcac   3900

agactgacca ttccatccca cagctgctgg acatagagtg atttgcagcc cctcctttca   3960

gagtaccaca tccctctcaa gtgttccaca acatctagga aagtgagctc ttaaagacag   4020

actaaaaaga gtaataaatc aatacaacaa cattaaaagc cagactagcg gagtttgaat   4080

cttggccctg ctgttagtaa ctgtgtgagc cttgggcaag ttactcagcc tccttgtgtc   4140

ttggttttgg tttcttcatc tctaagtaat tatatctgtc attattgccc tgatcacaaa   4200

caaaagcctg aatgtactat gtttaaaaga caaaccaaaa attaacccaa acttgcatta   4260

tttgtctgag ctacagaatg ttctttcctt ggagagatat ctgatattaa acatcatctg   4320

cattttactt gcctagaaaa tacacggtaa cttttctgcc ttgcagcatc aaactatagt   4380

acagctgagc cccagtgctg tgcagtctga ctctaattaa aggcaccttc tttacagcag   4440

ggctctgggg aactggaaaa gggggtttgt ttcattatct ggttttatta agcagatgaa   4500

tgcagccagc tatatgaagc actttgcagt gaatggcagg tgtcccatat ctggttatgt   4560

taacctagaa agggctcact ctacctctag gcatgtttca tcccaacaat cagactgtgc   4620

caaagcaggg gactttgtcc tttgtggatt gcatagctgg atacccatca tctgtttctc   4680

tgattggaag ctgctgttgt acagaaagac ctgcatttcc cccttgtctc cagttctctc   4740

actacttttt cctcctctgt gagtgaccat ccaggcagtc accataactg ctggagtgtc   4800

tgggattggt agctctctcc aactgcctgc ttgctcttta cagcctctct ctgtgactgg   4860

aatctctcca cctcatcgta tctaaggata acccagaaac atggggtgtc ctaggtatgt   4920

ttatctcgac actgaacccc ctaggcttct gatgaatcca gtgattagct aaatttgaca   4980

tagaaagtaa gaaggaatgt ctactttgta ttgtggtcct aatctaagat caggagaatc   5040

ctggaattgt tatctgtctc ttgctctgag atacagactt gttcataggt gtggggcctg   5100

attggaacag gatctgccat tggtcacaat aggtcaaggg cttgttctga accctagtta   5160

gcttcattca gagaaagaaa cttcctacct ggtcagcttt ttcagcttct ccaacaaatg   5220

ggagttgagg cagtaggagt gtggggttct tgggaagacg atggggcctt gtattaagga   5280

gaaataatga actatcttct tgattcttcc attgagaaaa gcatatgaat cctaggaaag   5340

ggctcagcct gtgataggca ttcaataaat actccaatgc tgtcattcct ttgtctacag   5400

catccccaaa caatgtacca gtgatgggct acctgagctc atctagtcgc caagcagtat   5460

ctcctgcttg ctgctgcttt actacattcc agatgcccac ctcatccaat ttccagagcc   5520

actatctctg ctgtccactt tccttcaggc tctgtgaata cttcaacctg ctgtgatttg   5580

gggccgtttg tactctgcat gtattcaata aattcaattc agcaatagtt aaaaaaaaa    5639


<210>  303
<211>  485
<212>  PRT
<213>  Homo sapiens

<400>  303


Met Gly Glu Pro Gly Phe Phe Val Thr Gly Asp Arg Ala Gly Gly Arg 
1               5                   10                  15      


Ser Trp Cys Leu Arg Arg Val Gly Met Ser Ala Gly Trp Leu Leu Leu 
            20                  25                  30          


Glu Asp Gly Cys Glu Val Thr Val Gly Arg Gly Phe Gly Val Thr Tyr 
        35                  40                  45              


Gln Leu Val Ser Lys Ile Cys Pro Leu Met Ile Ser Arg Asn His Cys 
    50                  55                  60                  


Val Leu Lys Gln Asn Pro Glu Gly Gln Trp Thr Ile Met Asp Asn Lys 
65                  70                  75                  80  


Ser Leu Asn Gly Val Trp Leu Asn Arg Ala Arg Leu Glu Pro Leu Arg 
                85                  90                  95      


Val Tyr Ser Ile His Gln Gly Asp Tyr Ile Gln Leu Gly Val Pro Leu 
            100                 105                 110         


Glu Asn Lys Glu Asn Ala Glu Tyr Glu Tyr Glu Val Thr Glu Glu Asp 
        115                 120                 125             


Trp Glu Thr Ile Tyr Pro Cys Leu Ser Pro Lys Asn Asp Gln Met Ile 
    130                 135                 140                 


Glu Lys Asn Lys Glu Leu Arg Thr Lys Arg Lys Phe Ser Leu Asp Glu 
145                 150                 155                 160 


Leu Ala Gly Pro Gly Ala Glu Gly Pro Ser Asn Leu Lys Ser Lys Ile 
                165                 170                 175     


Asn Lys Val Ser Cys Glu Ser Gly Gln Pro Val Lys Ser Gln Gly Lys 
            180                 185                 190         


Gly Glu Val Ala Ser Thr Pro Ser Asp Asn Leu Asp Pro Lys Leu Thr 
        195                 200                 205             


Ala Leu Glu Pro Ser Lys Thr Thr Gly Ala Pro Ile Tyr Pro Gly Phe 
    210                 215                 220                 


Pro Lys Val Thr Glu Val His His Glu Gln Lys Ala Ser Asn Ser Ser 
225                 230                 235                 240 


Ala Ser Gln Arg Ser Leu Gln Met Phe Lys Val Thr Met Ser Arg Ile 
                245                 250                 255     


Leu Arg Leu Lys Ile Gln Met Gln Glu Lys His Glu Ala Val Met Asn 
            260                 265                 270         


Val Lys Lys Gln Thr Gln Lys Gly Asn Ser Lys Lys Val Val Gln Met 
        275                 280                 285             


Glu Gln Glu Leu Gln Asp Leu Gln Ser Gln Leu Cys Ala Glu Gln Ala 
    290                 295                 300                 


Gln Gln Gln Ala Arg Val Glu Gln Leu Glu Lys Thr Phe Gln Glu Glu 
305                 310                 315                 320 


Glu Gln His Leu Gln Gly Leu Glu Ile Ala Gln Gly Glu Lys Asp Leu 
                325                 330                 335     


Lys Gln Gln Leu Ala Gln Ala Leu Gln Glu His Trp Ala Leu Met Glu 
            340                 345                 350         


Glu Leu Asn Arg Ser Lys Lys Asp Phe Glu Ala Ile Ile Gln Ala Lys 
        355                 360                 365             


Asn Lys Glu Leu Glu Gln Thr Lys Glu Glu Lys Glu Lys Met Gln Ala 
    370                 375                 380                 


Gln Lys Glu Glu Val Leu Ser His Met Asn Asp Val Leu Glu Asn Glu 
385                 390                 395                 400 


Leu Gln Cys Ile Ile Cys Ser Glu Tyr Phe Ile Glu Ala Val Thr Leu 
                405                 410                 415     


Asn Cys Ala His Ser Phe Cys Ser Tyr Cys Ile Asn Glu Trp Met Lys 
            420                 425                 430         


Arg Lys Ile Glu Cys Pro Ile Cys Arg Lys Asp Ile Lys Ser Lys Thr 
        435                 440                 445             


Tyr Ser Leu Val Leu Asp Asn Cys Ile Asn Lys Met Val Asn Asn Leu 
    450                 455                 460                 


Ser Ser Glu Val Lys Glu Arg Arg Ile Val Leu Ile Arg Glu Arg Lys 
465                 470                 475                 480 


Ala Lys Arg Leu Phe 
                485 

<210>  304
<211>  5434
<212>  DNA
<213>  Homo sapiens

<400>  304
cttgcgcagg cgtagtgctc ctgcttcctg gccgagggcg ggcgagcgga gcctgctttc     60

gcagcgatcg cgagcgtgtg gcgattgctt ctgtctgtta tttagatatg gaagctgagg    120

ggatgcacag aggcagccag aacctaggtc agggtctcgc tcggtgctga ccgcccccgg    180

ggtcgagtag gcgatggggg agcccggctt cttcgtcaca ggagaccgcg ccggtggccg    240

gagctggtgc ctgcggcggg tggggatgag cgccgggtgg ctgctgctgg aagatgggtg    300

cgaggtgact gtaggacgag gatttggtgt cacataccaa ctggtatcaa aaatctgccc    360

cctgatgatt tctcgaaacc actgtgtttt gaagcagaat cctgagggcc aatggacaat    420

tatggacaac aagagtctaa atggtgtttg gctgaacaga gcgcgtctgg aacctttaag    480

ggtctattcc attcatcagg gagactacat ccaacttgga gtgcctctgg aaaataagga    540

gaatgcggag tatgaatatg aagttactga agaagactgg gagacaatat atccttgtct    600

ttccccaaag aatgaccaaa tgatagaaaa aaataaggaa ttgagaacta aaaggaaatt    660

cagtttggat gaattagcag gtcctggagc tgaaggcccc tcaaatttga aatccaaaat    720

aaataaagtg tcttgtgaat ctggtcagcc agtgaaatca caggggaaag gtgaagtggc    780

cagtacaccc tctgacaatt tggatcctaa gttgactgcc cttgagccaa gtaagaccac    840

aggggctccc atttaccctg gcttccccaa agtcacagag gttcatcatg agcagaaagc    900

ctcaaactct tcagcatctc agagaagctt acagatgttt aaggtgacca tgtccaggat    960

tctgaggctc aaaatacaga tgcaggaaaa acatgaagcc gttatgaatg tgaaaaagca   1020

gacccaaaag gggaactcaa agaaagttgt gcaaatggag caggaacttc aggacttaca   1080

gtcccagctg tgtgcagagc aggctcagca gcaggcaaga gtggagcaac tagagaagac   1140

tttccaggaa gaggaacagc atcttcaggg tttggagata gcccaaggag aaaaggacct   1200

gaagcaacag ctggcccagg ctctgcagga gcattgggct ctaatggaag agctaaatcg   1260

cagcaagaag gactttgaag caatcattca agccaagaac aaagaattag agcagaccaa   1320

ggaagagaag gagaagatgc aagcacagaa ggaagaagtt cttagccaca tgaatgatgt   1380

gctagagaat gagctccaat gtattatttg ttcagaatac ttcattgagc aaagagattg   1440

ttctgaagac cgtgctctaa gggcatttga aagactgcca ggtagtgcga gcctgagatg   1500

gtctggagga ttctctctag ccgtgactcc gctgctctga aggtcaactg agaagtcttg   1560

tgggacagag acttgagtta ggaagccctc agtcacttgc cttccacggt ggccagccct   1620

gctgccatca ttggctgaag caccaccagg attcacggca cccaactgct tcagggtact   1680

tcgtagactc tgcctcacta catgtcgaaa gagttatttg agttctcttc tgtttttttt   1740

taatttgttg ttgttgttac tgttttgata cctcggaaac acctccgttg acagttgttt   1800

tggataggtt gggtgtaccc catggctgcc tctgaaggca gtgtctattt tgagaggatg   1860

gcttacctct tctttgtgaa aatactatct catttcctgg aaataaaatg taaaacctgt   1920

cagttgctca gctgggcttt ggtgtattta ccttccttcc cttcctgctc ccagacagtc   1980

tcacaagtaa acaccagcag ctcatagatt acaaccaaga aagtgactgt atcagatgat   2040

agacttcaag tgaatgtcag cctaagaggc caagctgcag atcgtggcaa cagatgagct   2100

ctgttaacct cctgactgtc gtgtttcctt tttattacag aggtgggtca ctgtttacct   2160

tgtttcaggg gtgggagaaa ctcctttcct tcagctggca tttgaatgtt tccaaatcta   2220

ttttatctga cgtcatgaac acacaggcaa tgattttatg acaacttgat gtgctttttt   2280

ctttattttt cttttacatt agaagttttc tctcttttct ccacctctcc tttattttta   2340

attttaattt taatttttga aacaagatct gactctgttg cccaagctgg agtacagtag   2400

tgcaatctca gctcactgca acctccacct cccagactca agccatcctc ccacctcaac   2460

ctcccaagta gctgggacta caggcatatg ccatcacacc cagctaattt ttgtttttct   2520

gtagagacag ggtttcacca tgttggccag gctggtctca aattcctgac cttaagtgat   2580

ccacctgcct aggcctctaa aatgctggga ttacaggcgt gagccaccac gcccagccta   2640

taccccatgt attttcataa agggttggaa actattgatt gccaactttt taaggatggt   2700

agggattttt tctttgttga atatactgtg aattttggga ttctggagtc cttagtcttc   2760

atttccattc ttctgcccat gattactgat caaaatactg gtagagtcat ggaggaagta   2820

agttaaatgt ggaaaaaatg ctttaaaagt acttactata accacatcat aagaattctg   2880

gaaaaataga gaacaaaagg aaaagattgt taccaccttg atttaataac ttcttgtttc   2940

cccatacatg tgttttgttt atagattgca tgggtatatg tcaattttta tatgttctgt   3000

gtttagttta catattgtaa ttcattttta agagagtaca gacatacact ttttgagtag   3060

gcaatatgtt cacatagttt gaaattaaag gtacaaaatg gcgtagaatg aaatgcctct   3120

caccctttcc ccacagcgac tacttcccac tcagaggcaa caagtattac agttgcttgt   3180

atattcttcc agagatctct gtctatacaa gcaaaaacac atgtggtctt tttccttgct   3240

ttgcacaaat ggtaaactgt acgctattct gaaccttgct tttttcagat atatgttggc   3300

aacagttcca tgtcagtaca tagtttcctt tctttattac agctgcctgt tttttcattg   3360

tgtatttgca ccatcattta cttttctggc ttacttttga tagaaatcta ggttggttca   3420

aaccttttta ctcttaaaac aatgctgcag ttaacaccct tgtacatata tctttagaga   3480

gaagatattt taaaaagaaa taccttttta aaaattattt tattattttt taatagagac   3540

tatgttgcct aggctggtct tgaaattctg ggctaaagca atcctaccac cttggcctcc   3600

caaagtgctg agattacagg catgagccat tgcacctggc caagaagaga catcttgact   3660

tgagcctgaa gactatgtac agagactgac ctcacagact gaccattcca tcccacagct   3720

gctggacata gagtgatttg cagcccctcc tttcagagta ccacatccct ctcaagtgtt   3780

ccacaacatc taggaaagtg agctcttaaa gacagactaa aaagagtaat aaatcaatac   3840

aacaacatta aaagccagac tagcggagtt tgaatcttgg ccctgctgtt agtaactgtg   3900

tgagccttgg gcaagttact cagcctcctt gtgtcttggt tttggtttct tcatctctaa   3960

gtaattatat ctgtcattat tgccctgatc acaaacaaaa gcctgaatgt actatgttta   4020

aaagacaaac caaaaattaa cccaaacttg cattatttgt ctgagctaca gaatgttctt   4080

tccttggaga gatatctgat attaaacatc atctgcattt tacttgccta gaaaatacac   4140

ggtaactttt ctgccttgca gcatcaaact atagtacagc tgagccccag tgctgtgcag   4200

tctgactcta attaaaggca ccttctttac agcagggctc tggggaactg gaaaaggggg   4260

tttgtttcat tatctggttt tattaagcag atgaatgcag ccagctatat gaagcacttt   4320

gcagtgaatg gcaggtgtcc catatctggt tatgttaacc tagaaagggc tcactctacc   4380

tctaggcatg tttcatccca acaatcagac tgtgccaaag caggggactt tgtcctttgt   4440

ggattgcata gctggatacc catcatctgt ttctctgatt ggaagctgct gttgtacaga   4500

aagacctgca tttccccctt gtctccagtt ctctcactac tttttcctcc tctgtgagtg   4560

accatccagg cagtcaccat aactgctgga gtgtctggga ttggtagctc tctccaactg   4620

cctgcttgct ctttacagcc tctctctgtg actggaatct ctccacctca tcgtatctaa   4680

ggataaccca gaaacatggg gtgtcctagg tatgtttatc tcgacactga accccctagg   4740

cttctgatga atccagtgat tagctaaatt tgacatagaa agtaagaagg aatgtctact   4800

ttgtattgtg gtcctaatct aagatcagga gaatcctgga attgttatct gtctcttgct   4860

ctgagataca gacttgttca taggtgtggg gcctgattgg aacaggatct gccattggtc   4920

acaataggtc aagggcttgt tctgaaccct agttagcttc attcagagaa agaaacttcc   4980

tacctggtca gctttttcag cttctccaac aaatgggagt tgaggcagta ggagtgtggg   5040

gttcttggga agacgatggg gccttgtatt aaggagaaat aatgaactat cttcttgatt   5100

cttccattga gaaaagcata tgaatcctag gaaagggctc agcctgtgat aggcattcaa   5160

taaatactcc aatgctgtca ttcctttgtc tacagcatcc ccaaacaatg taccagtgat   5220

gggctacctg agctcatcta gtcgccaagc agtatctcct gcttgctgct gctttactac   5280

attccagatg cccacctcat ccaatttcca gagccactat ctctgctgtc cactttcctt   5340

caggctctgt gaatacttca acctgctgtg atttggggcc gtttgtactc tgcatgtatt   5400

caataaattc aattcagcaa tagttaaaaa aaaa                               5434


<210>  305
<211>  448
<212>  PRT
<213>  Homo sapiens

<400>  305


Met Gly Glu Pro Gly Phe Phe Val Thr Gly Asp Arg Ala Gly Gly Arg 
1               5                   10                  15      


Ser Trp Cys Leu Arg Arg Val Gly Met Ser Ala Gly Trp Leu Leu Leu 
            20                  25                  30          


Glu Asp Gly Cys Glu Val Thr Val Gly Arg Gly Phe Gly Val Thr Tyr 
        35                  40                  45              


Gln Leu Val Ser Lys Ile Cys Pro Leu Met Ile Ser Arg Asn His Cys 
    50                  55                  60                  


Val Leu Lys Gln Asn Pro Glu Gly Gln Trp Thr Ile Met Asp Asn Lys 
65                  70                  75                  80  


Ser Leu Asn Gly Val Trp Leu Asn Arg Ala Arg Leu Glu Pro Leu Arg 
                85                  90                  95      


Val Tyr Ser Ile His Gln Gly Asp Tyr Ile Gln Leu Gly Val Pro Leu 
            100                 105                 110         


Glu Asn Lys Glu Asn Ala Glu Tyr Glu Tyr Glu Val Thr Glu Glu Asp 
        115                 120                 125             


Trp Glu Thr Ile Tyr Pro Cys Leu Ser Pro Lys Asn Asp Gln Met Ile 
    130                 135                 140                 


Glu Lys Asn Lys Glu Leu Arg Thr Lys Arg Lys Phe Ser Leu Asp Glu 
145                 150                 155                 160 


Leu Ala Gly Pro Gly Ala Glu Gly Pro Ser Asn Leu Lys Ser Lys Ile 
                165                 170                 175     


Asn Lys Val Ser Cys Glu Ser Gly Gln Pro Val Lys Ser Gln Gly Lys 
            180                 185                 190         


Gly Glu Val Ala Ser Thr Pro Ser Asp Asn Leu Asp Pro Lys Leu Thr 
        195                 200                 205             


Ala Leu Glu Pro Ser Lys Thr Thr Gly Ala Pro Ile Tyr Pro Gly Phe 
    210                 215                 220                 


Pro Lys Val Thr Glu Val His His Glu Gln Lys Ala Ser Asn Ser Ser 
225                 230                 235                 240 


Ala Ser Gln Arg Ser Leu Gln Met Phe Lys Val Thr Met Ser Arg Ile 
                245                 250                 255     


Leu Arg Leu Lys Ile Gln Met Gln Glu Lys His Glu Ala Val Met Asn 
            260                 265                 270         


Val Lys Lys Gln Thr Gln Lys Gly Asn Ser Lys Lys Val Val Gln Met 
        275                 280                 285             


Glu Gln Glu Leu Gln Asp Leu Gln Ser Gln Leu Cys Ala Glu Gln Ala 
    290                 295                 300                 


Gln Gln Gln Ala Arg Val Glu Gln Leu Glu Lys Thr Phe Gln Glu Glu 
305                 310                 315                 320 


Glu Gln His Leu Gln Gly Leu Glu Ile Ala Gln Gly Glu Lys Asp Leu 
                325                 330                 335     


Lys Gln Gln Leu Ala Gln Ala Leu Gln Glu His Trp Ala Leu Met Glu 
            340                 345                 350         


Glu Leu Asn Arg Ser Lys Lys Asp Phe Glu Ala Ile Ile Gln Ala Lys 
        355                 360                 365             


Asn Lys Glu Leu Glu Gln Thr Lys Glu Glu Lys Glu Lys Met Gln Ala 
    370                 375                 380                 


Gln Lys Glu Glu Val Leu Ser His Met Asn Asp Val Leu Glu Asn Glu 
385                 390                 395                 400 


Leu Gln Cys Ile Ile Cys Ser Glu Tyr Phe Ile Glu Gln Arg Asp Cys 
                405                 410                 415     


Ser Glu Asp Arg Ala Leu Arg Ala Phe Glu Arg Leu Pro Gly Ser Ala 
            420                 425                 430         


Ser Leu Arg Trp Ser Gly Gly Phe Ser Leu Ala Val Thr Pro Leu Leu 
        435                 440                 445             

<210>  306
<211>  3180
<212>  DNA
<213>  Homo sapiens

<400>  306
atacagtttc tctttgccag actagactaa agaaggagca ctaatttatt ctgataaaac     60

aggtctatgc agctaccagg acaatggaat ctacgttgac tttagcaacg gaacaacctg    120

ttaagaagaa cactcttaag aaatataaaa tagcttgcat tgttcttctt gctttgctgg    180

tgatcatgtc acttggatta ggcctggggc ttggactcag gaaactggaa aagcaaggca    240

gctgcaggaa gaagtgcttt gatgcatcat ttagaggact ggagaactgc cggtgtgatg    300

tggcatgtaa agaccgaggt gattgctgct gggattttga agacacctgt gtggaatcaa    360

ctcgaatatg gatgtgcaat aaatttcgtt gtggagagac cagattagag gccagccttt    420

gctcttgttc agatgactgt ttgcagagga aagattgctg tgctgactat aagagtgttt    480

gccaaggaga aacctcatgg ctggaagaaa actgtgacac agcccagcag tctcagtgcc    540

cagaagggtt tgacctgcca ccagttatct tgttttctat ggatggattt agagctgaat    600

atttatacac atgggatact ttaatgccaa atatcaataa actgaaaaca tgtggaattc    660

attcaaaata catgagagct atgtatccta ccaaaacctt cccaaatcat tacaccattg    720

tcacgggctt gtatccagag tcacatggca tcattgacaa taatatgtat gatgtaaatc    780

tcaacaagaa tttttcactt tcttcaaagg aacaaaataa tccagcctgg tggcatgggc    840

aaccaatgtg gctgacagca atgtatcaag gtttaaaagc cgctacctac ttttggcccg    900

gatcagaagt ggctataaat ggctcctttc cttccatata catgccttac aacggaagtg    960

tcccatttga agagaggatt tctacactgt taaaatggct ggacctgccc aaagctgaaa   1020

gacccaggtt ttataccatg tattttgaag aacctgattc ctctggacat gcaggtggac   1080

cagtcagtgc cagagtaatt aaagccttac aggtagtaga tcatgctttt gggatgttga   1140

tggaaggcct gaagcagcgg aatttgcaca actgtgtcaa tatcatcctt ctggctgacc   1200

atggaatgga ccagacttat tgtaacaaga tggaatacat gactgattat tttcccagaa   1260

taaacttctt ctacatgtac gaagggcctg ccccccgcat ccgagctcat aatatacctc   1320

atgacttttt tagttttaat tctgaggaaa ttgttagaaa cctcagttgc cgaaaacctg   1380

atcagcattt caagccctat ttgactcctg atttgccaaa gcgactgcac tatgccaaga   1440

acgtcagaat cgacaaagtt catctctttg tggatcaaca gtggctggct gttaggagta   1500

aatcaaatac aaattgtgga ggaggcaacc atggttataa caatgagttt aggagcatgg   1560

aggctatctt tctggcacat ggacccagtt ttaaagagaa gactgaagtt gaaccatttg   1620

aaaatattga agtctataac ctaatgtgtg atcttctacg cattcaacca gcaccaaaca   1680

atggaaccca tggtagttta aaccatcttc tgaaggtgcc tttttatgag ccatcccatg   1740

cagaggaggt gtcaaagttt tctgtttgtg gctttgctaa tccattgccc acagagtctc   1800

ttgactgttt ctgccctcac ctacaaaata gtactcagct ggaacaagtg aatcagatgc   1860

taaatctcac ccaagaagaa ataacagcaa cagtgaaagt aaatttgcca tttgggaggc   1920

ctagggtact gcagaagaac gtggaccact gtctccttta ccacagggaa tatgtcagtg   1980

gatttggaaa agctatgagg atgcccatgt ggagttcata cacagtcccc cagttgggag   2040

acacatcgcc tctgcctccc actgtcccag actgtctgcg ggctgatgtc agggttcctc   2100

cttctgagag ccaaaaatgt tccttctatt tagcagacaa gaatatcacc cacggcttcc   2160

tctatcctcc tgccagcaat agaacatcag atagccaata tgatgcttta attactagca   2220

atttggtacc tatgtatgaa gaattcagaa aaatgtggga ctacttccac agtgttcttc   2280

ttataaaaca tgccacagaa agaaatggag taaatgtggt tagtggacca atatttgatt   2340

ataattatga tggccatttt gatgctccag atgaaattac caaacattta gccaacactg   2400

atgttcccat cccaacacac tactttgtgg tgctgaccag ttgtaaaaac aagagccaca   2460

caccggaaaa ctgccctggg tggctggatg tcctaccctt tatcatccct caccgaccta   2520

ccaacgtgga gagctgtcct gaaggtaaac cagaagctct ttgggttgaa gaaagattta   2580

cagctcacat tgcccgggtc cgtgatgtag aacttctcac tgggcttgac ttctatcagg   2640

ataaagtgca gcctgtctct gaaattttgc aactaaagac atatttacca acatttgaaa   2700

ccactattta acttaataat gtctacttaa tatataattt actgtataaa gtaattttgg   2760

caaaatataa gtgatttttt tctggagaat tgtaaaataa agttttctat ttttccttaa   2820

gtcccctaaa agccataatt tttattattc ctttttctct tttttcaatt ctatgaatat   2880

gtattatttt aaagttatat ttttcacaca gagatgatgc tatattacac cttccctttt   2940

ttgttggttt cttaaactct aatctcatga cagattatac cttccttatt acttgtttta   3000

tcttactcag aatctttgaa tatatttttc tgcccagaat tatctaaaca aaagggagaa   3060

caaaagaagt atgtctcact tgggaactga atcaactcta aatcagtttt gtcacaaaac   3120

tttttgtatt tgactggcaa tgctgattaa aattaaaaat gcacaaaaaa aaaaaaaaaa   3180


<210>  307
<211>  875
<212>  PRT
<213>  Homo sapiens

<400>  307


Met Glu Ser Thr Leu Thr Leu Ala Thr Glu Gln Pro Val Lys Lys Asn 
1               5                   10                  15      


Thr Leu Lys Lys Tyr Lys Ile Ala Cys Ile Val Leu Leu Ala Leu Leu 
            20                  25                  30          


Val Ile Met Ser Leu Gly Leu Gly Leu Gly Leu Gly Leu Arg Lys Leu 
        35                  40                  45              


Glu Lys Gln Gly Ser Cys Arg Lys Lys Cys Phe Asp Ala Ser Phe Arg 
    50                  55                  60                  


Gly Leu Glu Asn Cys Arg Cys Asp Val Ala Cys Lys Asp Arg Gly Asp 
65                  70                  75                  80  


Cys Cys Trp Asp Phe Glu Asp Thr Cys Val Glu Ser Thr Arg Ile Trp 
                85                  90                  95      


Met Cys Asn Lys Phe Arg Cys Gly Glu Thr Arg Leu Glu Ala Ser Leu 
            100                 105                 110         


Cys Ser Cys Ser Asp Asp Cys Leu Gln Arg Lys Asp Cys Cys Ala Asp 
        115                 120                 125             


Tyr Lys Ser Val Cys Gln Gly Glu Thr Ser Trp Leu Glu Glu Asn Cys 
    130                 135                 140                 


Asp Thr Ala Gln Gln Ser Gln Cys Pro Glu Gly Phe Asp Leu Pro Pro 
145                 150                 155                 160 


Val Ile Leu Phe Ser Met Asp Gly Phe Arg Ala Glu Tyr Leu Tyr Thr 
                165                 170                 175     


Trp Asp Thr Leu Met Pro Asn Ile Asn Lys Leu Lys Thr Cys Gly Ile 
            180                 185                 190         


His Ser Lys Tyr Met Arg Ala Met Tyr Pro Thr Lys Thr Phe Pro Asn 
        195                 200                 205             


His Tyr Thr Ile Val Thr Gly Leu Tyr Pro Glu Ser His Gly Ile Ile 
    210                 215                 220                 


Asp Asn Asn Met Tyr Asp Val Asn Leu Asn Lys Asn Phe Ser Leu Ser 
225                 230                 235                 240 


Ser Lys Glu Gln Asn Asn Pro Ala Trp Trp His Gly Gln Pro Met Trp 
                245                 250                 255     


Leu Thr Ala Met Tyr Gln Gly Leu Lys Ala Ala Thr Tyr Phe Trp Pro 
            260                 265                 270         


Gly Ser Glu Val Ala Ile Asn Gly Ser Phe Pro Ser Ile Tyr Met Pro 
        275                 280                 285             


Tyr Asn Gly Ser Val Pro Phe Glu Glu Arg Ile Ser Thr Leu Leu Lys 
    290                 295                 300                 


Trp Leu Asp Leu Pro Lys Ala Glu Arg Pro Arg Phe Tyr Thr Met Tyr 
305                 310                 315                 320 


Phe Glu Glu Pro Asp Ser Ser Gly His Ala Gly Gly Pro Val Ser Ala 
                325                 330                 335     


Arg Val Ile Lys Ala Leu Gln Val Val Asp His Ala Phe Gly Met Leu 
            340                 345                 350         


Met Glu Gly Leu Lys Gln Arg Asn Leu His Asn Cys Val Asn Ile Ile 
        355                 360                 365             


Leu Leu Ala Asp His Gly Met Asp Gln Thr Tyr Cys Asn Lys Met Glu 
    370                 375                 380                 


Tyr Met Thr Asp Tyr Phe Pro Arg Ile Asn Phe Phe Tyr Met Tyr Glu 
385                 390                 395                 400 


Gly Pro Ala Pro Arg Ile Arg Ala His Asn Ile Pro His Asp Phe Phe 
                405                 410                 415     


Ser Phe Asn Ser Glu Glu Ile Val Arg Asn Leu Ser Cys Arg Lys Pro 
            420                 425                 430         


Asp Gln His Phe Lys Pro Tyr Leu Thr Pro Asp Leu Pro Lys Arg Leu 
        435                 440                 445             


His Tyr Ala Lys Asn Val Arg Ile Asp Lys Val His Leu Phe Val Asp 
    450                 455                 460                 


Gln Gln Trp Leu Ala Val Arg Ser Lys Ser Asn Thr Asn Cys Gly Gly 
465                 470                 475                 480 


Gly Asn His Gly Tyr Asn Asn Glu Phe Arg Ser Met Glu Ala Ile Phe 
                485                 490                 495     


Leu Ala His Gly Pro Ser Phe Lys Glu Lys Thr Glu Val Glu Pro Phe 
            500                 505                 510         


Glu Asn Ile Glu Val Tyr Asn Leu Met Cys Asp Leu Leu Arg Ile Gln 
        515                 520                 525             


Pro Ala Pro Asn Asn Gly Thr His Gly Ser Leu Asn His Leu Leu Lys 
    530                 535                 540                 


Val Pro Phe Tyr Glu Pro Ser His Ala Glu Glu Val Ser Lys Phe Ser 
545                 550                 555                 560 


Val Cys Gly Phe Ala Asn Pro Leu Pro Thr Glu Ser Leu Asp Cys Phe 
                565                 570                 575     


Cys Pro His Leu Gln Asn Ser Thr Gln Leu Glu Gln Val Asn Gln Met 
            580                 585                 590         


Leu Asn Leu Thr Gln Glu Glu Ile Thr Ala Thr Val Lys Val Asn Leu 
        595                 600                 605             


Pro Phe Gly Arg Pro Arg Val Leu Gln Lys Asn Val Asp His Cys Leu 
    610                 615                 620                 


Leu Tyr His Arg Glu Tyr Val Ser Gly Phe Gly Lys Ala Met Arg Met 
625                 630                 635                 640 


Pro Met Trp Ser Ser Tyr Thr Val Pro Gln Leu Gly Asp Thr Ser Pro 
                645                 650                 655     


Leu Pro Pro Thr Val Pro Asp Cys Leu Arg Ala Asp Val Arg Val Pro 
            660                 665                 670         


Pro Ser Glu Ser Gln Lys Cys Ser Phe Tyr Leu Ala Asp Lys Asn Ile 
        675                 680                 685             


Thr His Gly Phe Leu Tyr Pro Pro Ala Ser Asn Arg Thr Ser Asp Ser 
    690                 695                 700                 


Gln Tyr Asp Ala Leu Ile Thr Ser Asn Leu Val Pro Met Tyr Glu Glu 
705                 710                 715                 720 


Phe Arg Lys Met Trp Asp Tyr Phe His Ser Val Leu Leu Ile Lys His 
                725                 730                 735     


Ala Thr Glu Arg Asn Gly Val Asn Val Val Ser Gly Pro Ile Phe Asp 
            740                 745                 750         


Tyr Asn Tyr Asp Gly His Phe Asp Ala Pro Asp Glu Ile Thr Lys His 
        755                 760                 765             


Leu Ala Asn Thr Asp Val Pro Ile Pro Thr His Tyr Phe Val Val Leu 
    770                 775                 780                 


Thr Ser Cys Lys Asn Lys Ser His Thr Pro Glu Asn Cys Pro Gly Trp 
785                 790                 795                 800 


Leu Asp Val Leu Pro Phe Ile Ile Pro His Arg Pro Thr Asn Val Glu 
                805                 810                 815     


Ser Cys Pro Glu Gly Lys Pro Glu Ala Leu Trp Val Glu Glu Arg Phe 
            820                 825                 830         


Thr Ala His Ile Ala Arg Val Arg Asp Val Glu Leu Leu Thr Gly Leu 
        835                 840                 845             


Asp Phe Tyr Gln Asp Lys Val Gln Pro Val Ser Glu Ile Leu Gln Leu 
    850                 855                 860                 


Lys Thr Tyr Leu Pro Thr Phe Glu Thr Thr Ile 
865                 870                 875 

<210>  308
<211>  933
<212>  DNA
<213>  Homo sapiens

<400>  308
atgggagaca atataacatc catcagagag ttcctcctac tgggatttcc cgttggccca     60

aggattcaga tgctcctctt tgggctcttc tccctgttct acgtcttcac cctgctgggg    120

aacgggacca tactggggct catctcactg gactccagac tgcacgcccc catgtacttc    180

ttcctctcac acctggcggt cgtcgacatc gcctacgcct gcaacacggt gccccggatg    240

ctggtgaacc tcctgcatcc agccaagccc atctcctttg cgggccgcat gatgcagacc    300

tttctgtttt ccacttttgc tgtcacagaa tgtctcctcc tggtggtgat gtcctatgat    360

ctgtacgtgg ccatctgcca ccccctccga tatttggcca tcatgacctg gagagtctgc    420

atcaccctcg cggtgacttc ctggaccact ggagtccttt tatccttgat tcatcttgtg    480

ttacttctac ctttaccctt ctgtaggccc cagaaaattt atcacttttt ttgtgaaatc    540

ttggctgttc tcaaacttgc ctgtgcagat acccacatca atgagaacat ggtcttggcc    600

ggagcaattt ctgggctggt gggacccttg tccacaattg tagtttcata tatgtgcatc    660

ctctgtgcta tccttcagat ccaatcaagg gaagttcaga ggaaagcctt ccgcacctgc    720

ttctcccacc tctgtgtgat tggactcgtt tatggcacag ccattatcat gtatgttgga    780

cccagatatg ggaaccccaa ggagcagaag aaatatctcc tgctgtttca cagcctcttt    840

aatcccatgc tcaatcccct tatctgtagt cttaggaact cagaagtgaa gaatactttg    900

aagagagtgc tgggagtaga aagggcttta tga                                 933


<210>  309
<211>  310
<212>  PRT
<213>  Homo sapiens

<400>  309


Met Gly Asp Asn Ile Thr Ser Ile Arg Glu Phe Leu Leu Leu Gly Phe 
1               5                   10                  15      


Pro Val Gly Pro Arg Ile Gln Met Leu Leu Phe Gly Leu Phe Ser Leu 
            20                  25                  30          


Phe Tyr Val Phe Thr Leu Leu Gly Asn Gly Thr Ile Leu Gly Leu Ile 
        35                  40                  45              


Ser Leu Asp Ser Arg Leu His Ala Pro Met Tyr Phe Phe Leu Ser His 
    50                  55                  60                  


Leu Ala Val Val Asp Ile Ala Tyr Ala Cys Asn Thr Val Pro Arg Met 
65                  70                  75                  80  


Leu Val Asn Leu Leu His Pro Ala Lys Pro Ile Ser Phe Ala Gly Arg 
                85                  90                  95      


Met Met Gln Thr Phe Leu Phe Ser Thr Phe Ala Val Thr Glu Cys Leu 
            100                 105                 110         


Leu Leu Val Val Met Ser Tyr Asp Leu Tyr Val Ala Ile Cys His Pro 
        115                 120                 125             


Leu Arg Tyr Leu Ala Ile Met Thr Trp Arg Val Cys Ile Thr Leu Ala 
    130                 135                 140                 


Val Thr Ser Trp Thr Thr Gly Val Leu Leu Ser Leu Ile His Leu Val 
145                 150                 155                 160 


Leu Leu Leu Pro Leu Pro Phe Cys Arg Pro Gln Lys Ile Tyr His Phe 
                165                 170                 175     


Phe Cys Glu Ile Leu Ala Val Leu Lys Leu Ala Cys Ala Asp Thr His 
            180                 185                 190         


Ile Asn Glu Asn Met Val Leu Ala Gly Ala Ile Ser Gly Leu Val Gly 
        195                 200                 205             


Pro Leu Ser Thr Ile Val Val Ser Tyr Met Cys Ile Leu Cys Ala Ile 
    210                 215                 220                 


Leu Gln Ile Gln Ser Arg Glu Val Gln Arg Lys Ala Phe Arg Thr Cys 
225                 230                 235                 240 


Phe Ser His Leu Cys Val Ile Gly Leu Val Tyr Gly Thr Ala Ile Ile 
                245                 250                 255     


Met Tyr Val Gly Pro Arg Tyr Gly Asn Pro Lys Glu Gln Lys Lys Tyr 
            260                 265                 270         


Leu Leu Leu Phe His Ser Leu Phe Asn Pro Met Leu Asn Pro Leu Ile 
        275                 280                 285             


Cys Ser Leu Arg Asn Ser Glu Val Lys Asn Thr Leu Lys Arg Val Leu 
    290                 295                 300                 


Gly Val Glu Arg Ala Leu 
305                 310 

<210>  310
<211>  3894
<212>  DNA
<213>  Homo sapiens

<400>  310
tatgtttctt gtatgctgtg tacaagaaac tcacttgaat tttaccaata cagggcaggc     60

caaattaaca ggatgaaaaa agatatatta cacaaacatt aatgaaagga aagcaagagt    120

gtctgtatgc atatcagata aagcaaagaa aactaccaaa accagagatt atgtaatgat    180

caaaggttta atccatgaag aagacagcaa ttttaaaagt gtattcacca aaaaataaag    240

cttcaaaata tgtgatgtga aaactgccag aactaaggcg ggccgggctc agaccagcgc    300

tgcctcagga tgtaaagtgt aacaagaggg ccaggggagg tggtggggga caacatgggc    360

ctgtgaggcc tgtgggtgcc cgcgttcccc agctcccccc gcagcccgct ccacagtggt    420

ccgctccggt tggttgtcac gtgcgcattc gggttccaga cccaaggctg cgtgttctcc    480

accgcttgtt gtggccagtg ttactgcggt gaccgccaga gcagcctcga cgctatggag    540

gagcctggtg ctacccctca gccctacctg gggctggtcc tggaggagct aggcagagtt    600

gtggcagcac tacctgagag tatgagacca gatgagaatc cttatggttt tccatcggaa    660

ctggtggtat gtgcagctgt tattggattt tttgttgttc tccttttttt gtggagaagt    720

tttagatcgg ttaggagtcg gctttatgtg ggaagagagc aaaaacttgg tgcaacgctt    780

tctggactaa ttgaagaaaa atgtaaacta cttgaaaagt ttagccttat tcaaaaagag    840

tatgaaggct atgaagtaga gtcatcttta gaggatgcca gctttgagaa ggcggcagca    900

gaagaagcac gaagtttgga ggcaacctgt gaaaagctga gcaggtccaa ttctgaactt    960

gaggatgaaa tcctctgtct agaaaaagac ttaaaagaag agaaatctaa acattctcaa   1020

caagatgaat tgatggcgga tatttcaaaa agtatacagt ctctagaaga tgagtcaaaa   1080

tccctcaaat cacaaatagc tgaagccaaa atcatctgca agacatttaa aatgagtgaa   1140

gaacgacggg ctatagcaat aaaagatgct ttgaatgaaa attctcaact tcagacaagc   1200

cataaacagc tttttcagca agaagctgaa gtatggaaag gacaagtgag tgaacttaat   1260

aaacagaaaa taacatttga agactccaaa gtacacgcag aacaagttct gaatgataaa   1320

gaaaatcaca tcaagaccct gactggacac ttgccaatga tgaaagatca ggctgctgtg   1380

cttgaagaag acacaacgga tgatgataac ctggaattaa aagtgaacag tcaatgggaa   1440

aatggtgcta acttagatga tcctccgaaa ggagctttga agaaactgat tcatgctgct   1500

aagttaaatg tttctttaaa aagcttagaa ggagaaagaa accacattat tattcagtta   1560

tctgaagtgg acaaaacaaa ggaagagctt acagagcata ttaaaaatct tcagactcaa   1620

caagcatctt tgcaatcaga aaacatatat tttgaaagtg agaatcagaa gcttcaacag   1680

aaacttaaaa taatgactga attctatcaa gaaaatgaaa tgaaactcta caggaaatta   1740

acagtggagg aaaattaccg aatagaggaa gaagagaagc tttctagagt ggaagaaaag   1800

atcagccatg ccactgaaga gctggagacc tatagaaagc tagccaaaga tcttgaagaa   1860

gaattggaga gaactgttca tttttatcaa aagcaggtta tttcctacga gaaaagagga   1920

catgataatt ggttggcagc tcggactgct gaaagaaacc tcagtgattt aaggaaagaa   1980

aatgctcaca acaaacaaaa attaactgaa agagagttga aatttgaact tttagaaaaa   2040

gatcctaatg cactcgatgt ttcaaataca gcatttggca gagagcattc cccatgtagt   2100

ccctcaccat tgggtcggcc ttcatctgaa acgagagctt ttccctctcc tcaaactttg   2160

ttggaggatc cactcagact ctcacctgtg cttccagggg gaggaggaag aggcccaagc   2220

agcccaggga atcccctgga ccatcagatt accaatgaaa gaggagaacc aagctatgac   2280

aggttaatcg atcctcacag ggctccttct gacactgggt ccctgtcatc tccggtggaa   2340

caggaccgta ggatgatgtt tcctccacca gggcaatcat atcctgattc aactcttcct   2400

ccacaaaggg aagacagatt ttattctaat tctgaaagac tgtctggacc agcagaaccc   2460

agaagtttta aaatgacttc tttggataaa atggataggt caatgccttc agaaatggaa   2520

tccagtagaa atgatgccaa agatgatctt ggtaatttaa atgtgcctga ttcatctctc   2580

cctgctgaaa atgaagcaac tggccctggc cttattcctc cacctcttgc tccaatcagc   2640

ggtccattgt ttccagtgga tacaaggggc ccattcatga gaagaggacc tcctttcccc   2700

ccacctcctc caggaaccat gtttggagct tctcgaggtt attttccacc aagggatttc   2760

ccaggtccac cacatgctcc atttgcaatg agaaacatct atccaccgag gggtttacct   2820

ccttaccttc atccgagacc tggattttac cccaacccca cattctgaag gtagaagcga   2880

gttcccttca ggattgattc cgccttcaaa ggagcctgct actggacatc cagaaccaca   2940

gcaagacacc tgacaatatt gttgctttct tcaaaagtaa ttttgactga tctcattttc   3000

agtttaagta actgctgtta cttaagtgat tgcacttttc tcaaattgaa gtttaatgga   3060

ataatagttc tcaggatagt attttgtaaa taaagatggt ttgaatatga atcttatgag   3120

taaatcattt ccattttatt atattctaga tcatataact tttaacttgg tgaactaatc   3180

cactcttaga gaaacaatag tgggagtttt atatatgtaa tcttgcaggt gaggaggctt   3240

taaattctaa aggttgtggt gtcttcatgc caagaactgt attcactgtg gttgtagata   3300

aatgtgaaag taactttatg cttaatttaa taaattttca ttgatttttt taaaaaaaga   3360

aaactgaaag gagatataga tgaatccaca attatagtta gaaatttcct catgcctttt   3420

tcaataattg atagaactag acagaaaatc agcaaggagt gttggctttg gcagcacttt   3480

ctaaaatcag aatgatgcca acaagattaa aacggttctt gaatatagat tacacaaaat   3540

tttgtgaagc atttcatgtt tttaaaaaga ggaaaaaaaa gaaaatcaac aagaatataa   3600

aacaactcaa aatgccatta accaaaagaa tctatttggc atttacagaa tattccacac   3660

agtaacagca gaatacacat attttttttg agtgctgacg aaacacctgg caagatagag   3720

ctgtcctagg ccctaaaact cgccacaaca aatttaaaag agatagtaat catccagagc   3780

agatgaaaac cagaaatcat tgtagggaat ccaattggaa atcagcataa gaaagatatg   3840

aaaatcccta aacatttgga aatttaaaaa cacacttcac aataatctat cagt         3894


<210>  311
<211>  1613
<212>  DNA
<213>  Homo sapiens

<400>  311
aagctactca gataagaggc tccaagagga catttttgga tgtgaaaaac aatgagaagg     60

aggacaacac acatttacaa tcgtcttaat tttgtactca gaaaaaggat gtgaagacaa    120

tgcacaggga atacaatagt ttcagatctg tgtacagttt ccttttgctt catctcctgc    180

aacaatgtaa tgaagacacc atgatatcat taacatttca cacaaaagga aaatgaggct    240

gaaatggtgt gggcaaggcc caggaatctg gagcatccct aaccaagcag cagagcacct    300

gggatagaga aagtgctcaa gaatgttcac ttactgatta ctacaatcaa aaaaagatac    360

gacactaatt taccacattc ttcttactta ttttatgaga tactattctt ccaaggtgga    420

gaaagtggag aaagtagagt gacgcagcta agggagtaaa tcgaccctca gccaacaagt    480

ggcaaaagcc tgaagaaagt gatcaagatc actgatgacc ccgcggccca tctccaaggg    540

ggcgggtatc acaaccccga cgccacacca cgtatcattc cgcaaaactc ccgcgcctcc    600

cacgcagaac tggcaagagg gaaggcgaga cagcagtgaa cagctggtac gcagcaccca    660

cagcaccgcg gcagcagcta gtgccgactc ccgcctagct cttttgactc tgttcgcggg    720

aagaatgggg aaacagtaag gttgcggcgc ctcccgcgag acgaggtacc tgaggctggc    780

cccgcagtcc cccgccgcac cagcaccgga gcttcacacc ccacttccgg ggtcaagtca    840

ccgccgggaa tcctgtgatc gcagaaaggt agtctcaggt tccgccccta tccaagtccc    900

gcctccactg cctctcgccc tgtatctgtc aacttccggg acgccgcgcg tcactaagca    960

gccaatctcc acttccggac tcatccagcc ccttctccac ccctttcaga gacagcgcga   1020

ttgcgattta ggtttccgcg catttaattg gcgaagctgg agcgctagtc ttcgctgatt   1080

ggtgccgaga aatctgcccc atagacaccc gcggggcgca cagtttcagt cgtccgtggg   1140

tttcccgcca gccgcagtct tggaccataa tcatggtgga catgatggac ttgcccaggt   1200

cgcgcatcaa cgccggcatg ctagctcaat tcatcgacaa gcctgtctgc ttcgtaggga   1260

ggctggaaaa gattcatccc accggaaaaa tgtttattct ttcagatgga gaaggaaaaa   1320

atggaaccat cgagttgatg gaaccccttg atgaagaaat ctctggaatt gtggaagtgg   1380

ttggaagagt aaccgccaag gccaccatct tgtgtacatc ttatgtccag tttaaagaag   1440

atagccatcc ttttgatctt ggactttaca atgaagctgt gaaaattatc catgacttcc   1500

ctcagtttta tcctttaggg attgtgcaac atgattgatc ttgatggatt ttcatacgat   1560

tgtaaatgag ctatattaaa gtctattaaa ggaaaaaaaa aaaaaaaaaa aaa          1613


<210>  312
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  312


Met Val Asp Met Met Asp Leu Pro Arg Ser Arg Ile Asn Ala Gly Met 
1               5                   10                  15      


Leu Ala Gln Phe Ile Asp Lys Pro Val Cys Phe Val Gly Arg Leu Glu 
            20                  25                  30          


Lys Ile His Pro Thr Gly Lys Met Phe Ile Leu Ser Asp Gly Glu Gly 
        35                  40                  45              


Lys Asn Gly Thr Ile Glu Leu Met Glu Pro Leu Asp Glu Glu Ile Ser 
    50                  55                  60                  


Gly Ile Val Glu Val Val Gly Arg Val Thr Ala Lys Ala Thr Ile Leu 
65                  70                  75                  80  


Cys Thr Ser Tyr Val Gln Phe Lys Glu Asp Ser His Pro Phe Asp Leu 
                85                  90                  95      


Gly Leu Tyr Asn Glu Ala Val Lys Ile Ile His Asp Phe Pro Gln Phe 
            100                 105                 110         


Tyr Pro Leu Gly Ile Val Gln His Asp 
        115                 120     

<210>  313
<211>  2203
<212>  DNA
<213>  Homo sapiens

<400>  313
ggtgcggcgg gggactgcgg ggccagcctc aggtacctcc agtagcagca gcagcagcag     60

cagcagcagc agcagcagca gcagcagcag cagcagcagc agcaatgttt cacttcttca    120

gaaagcctcc ggaatctaaa aagccctcag taccagagac agaagcagat ggattcgtcc    180

ttttaggaga tacaacagat gagcaaagaa tgacagcaag aggcaaaact tcggacatag    240

aggccaacca acctttggag accaacaaag aaaattcatc cagtgtgact gtatcagacc    300

ctgagatgga aaataaggca ggccagactc tggagaacag ctcattaatg gccgagctcc    360

tgagcgatgt gccgttcacc ctggccccgc atgtgctggc agtacagggc accatcactg    420

accttcccga ccacttactc tcctatgatg gcagcgaaaa cttatcacgg ttttggtatg    480

atttcactct tgaaaattca gtgctctgtg attcataacc tttatgtctg tttgcacctt    540

aacagcttta aaatatgttc gcctatttta tctaacctgt ttgatgttct ttgccgtttc    600

actgtttaag gtcctcagca aggatcataa agcaaagaaa atagcattat gttcactact    660

ctatttttaa gaaaaaggta catttgtata caaattgaac ttaagttcta cttcctttct    720

cccatataat aaatatacaa attaggctat gaaggtttta ggaaaggact cgattccttc    780

agatggtctc tcaaaatata acacctcaaa tttatcttag aagaactgtg aaaaagaatt    840

gtggcatttt tcagtcacta cagctccgaa gtctgagcaa gaagtgggtg tgaagtctcc    900

tctctggttt gtaggaagtt gaattggtgt tattcctgca tttttttctt ccacagtgtt    960

tatgaatgaa ttcagaaaaa aagttgccag ttagcttaat ttcttcagat gcattgatgt   1020

ggaaatttaa aacttgtcct aaacagcagt gctagtttgc tgatacaagg atgctagacc   1080

tgctctgcgt gctctttctg gagtggccca tttcggtttt ctgaaaccca tggcagccct   1140

ttccatcgtg aataatcgtt gtgttcccac ctttgttctc tgcctttttg ctacttcagt   1200

gtgctctctg accagctttc caaagaactt tccctgcttc tgcctcggtt gccatttgct   1260

ctccttacca catatgttcc cagtttatga agagatccac atttcctttc aacccctctg   1320

cctcctgaag aaaaacatct catgatgata catattattg ctgataacac ccttatttag   1380

aaatttgttg gccacaatag agatggaaat gttttactgc tggaaaaact gaaatcaact   1440

catttccaat tagagtatag gcagaacacc tagatatgac ttttagttct tgaatatcca   1500

ttacttactt taatgaaaac agaactgcca ttggtcaata aactgtaaag ggaagaggta   1560

aattgtgata gagaattttc tatgtcatgg gaaattgaaa tcacatttat tttgattacc   1620

agcaatatga tttgttaact ctgtgccaag ttttaagtat attttttcac aaagatagag   1680

tgccatagtg aaactaaaca ctgtgcataa aggtacatga attattccag ttttaaagta   1740

ttatgcatgt ttgtttaata aatgtggcat ggttttaata caaatgctat gttatttaaa   1800

agttagagga acatttctat tgacaaaaat atgcttcatt tacatataat gttaccatat   1860

ggtgttaatg attaaattag atctttacat agttcttaca aagcatcagt ctaggaaata   1920

tgacttatta ctgatgcaaa cgtgaacatt ttgtagtagt tttgtaaaag aacatccttt   1980

tcaaatatct gtgttaatgt acccttgaaa ttaaatgcaa gcacatagtc agtttgtcta   2040

attttgtgtg aaattttgtc gaaaatacct aaacatttca tctatatttg tgcctaccat   2100

gttataaatg ttcataagta ccttcatgtg tctataaaaa atgttatatt taaataaatg   2160

tgaattaaaa taaaattttt gattattttc agatccagaa aaa                     2203


<210>  314
<211>  856
<212>  DNA
<213>  Homo sapiens

<400>  314
gcctcggtga tgtcgtgggt tcaagcagcc tccttgatcc agggccctgg agacaaaggg     60

gacgtgtttg acgaagaagc agacgagtcg ctcctggcgc agcgggaatg gcagagtaac    120

atgcaaagac gagtcaaaga aggttataga gatggaatag atgctggcaa agcagttact    180

cttcaacagg gcttcaatca aggttataag aaaggtgcag aagtcatttt aaactatgga    240

cgactccgag gaacattgag tgctttgctc tcctggtgtc accttcataa taataattca    300

actttgatca ataaaataaa caatcttctg gatgcagttg gccagtgtga agagtatgtg    360

ctcaaacatc tgaaatcaat cactccaccg tcccatgttg tagatttatt ggactccatt    420

gaggatatgg acctttgtca tgtagttcca gctgagaaaa agattgatga agctaaagat    480

gaaagactct gtgaaaataa tgctgagttt aacaaaaact gtagcaagag ccatagtggg    540

atagattgtt catatgtaga atgttgtaga acacaggagc atgcacattc agaaaaccca    600

agccccacat ggattttgga acagacagcc agtttagtta aacagctggg cctatcagta    660

gatgtattac aacacctcaa acaactataa aattaccttc ccttttctaa tgaaaataat    720

gttcagaaca tttggtttcc taacaatcga aatttgtact ggtttctgca tcaaacacct    780

caactgtagg gttacccttt atggaagttt gaaattaaca ctattgtctt caaaattaac    840

actattaaat gtaata                                                    856


<210>  315
<211>  226
<212>  PRT
<213>  Homo sapiens

<400>  315


Met Ser Trp Val Gln Ala Ala Ser Leu Ile Gln Gly Pro Gly Asp Lys 
1               5                   10                  15      


Gly Asp Val Phe Asp Glu Glu Ala Asp Glu Ser Leu Leu Ala Gln Arg 
            20                  25                  30          


Glu Trp Gln Ser Asn Met Gln Arg Arg Val Lys Glu Gly Tyr Arg Asp 
        35                  40                  45              


Gly Ile Asp Ala Gly Lys Ala Val Thr Leu Gln Gln Gly Phe Asn Gln 
    50                  55                  60                  


Gly Tyr Lys Lys Gly Ala Glu Val Ile Leu Asn Tyr Gly Arg Leu Arg 
65                  70                  75                  80  


Gly Thr Leu Ser Ala Leu Leu Ser Trp Cys His Leu His Asn Asn Asn 
                85                  90                  95      


Ser Thr Leu Ile Asn Lys Ile Asn Asn Leu Leu Asp Ala Val Gly Gln 
            100                 105                 110         


Cys Glu Glu Tyr Val Leu Lys His Leu Lys Ser Ile Thr Pro Pro Ser 
        115                 120                 125             


His Val Val Asp Leu Leu Asp Ser Ile Glu Asp Met Asp Leu Cys His 
    130                 135                 140                 


Val Val Pro Ala Glu Lys Lys Ile Asp Glu Ala Lys Asp Glu Arg Leu 
145                 150                 155                 160 


Cys Glu Asn Asn Ala Glu Phe Asn Lys Asn Cys Ser Lys Ser His Ser 
                165                 170                 175     


Gly Ile Asp Cys Ser Tyr Val Glu Cys Cys Arg Thr Gln Glu His Ala 
            180                 185                 190         


His Ser Glu Asn Pro Ser Pro Thr Trp Ile Leu Glu Gln Thr Ala Ser 
        195                 200                 205             


Leu Val Lys Gln Leu Gly Leu Ser Val Asp Val Leu Gln His Leu Lys 
    210                 215                 220                 


Gln Leu 
225     

<210>  316
<211>  195
<212>  DNA
<213>  Homo sapiens

<400>  316
atgtctggca gcaaaggtgg caagaagaag gccctgaaac agcccaagaa gcaggccaag     60

gagaaggacg aggaagataa ggctttcaag cagaaacaaa aagaggagca gaagaaactc    120

gaggagctaa acatgaaggc cgtggggaag tggcccctgg ccacaggtgg aattaagaaa    180

tttgccaaaa agtga                                                     195


<210>  317
<211>  64
<212>  PRT
<213>  Homo sapiens

<400>  317


Met Ser Gly Ser Lys Gly Gly Lys Lys Lys Ala Leu Lys Gln Pro Lys 
1               5                   10                  15      


Lys Gln Ala Lys Glu Lys Asp Glu Glu Asp Lys Ala Phe Lys Gln Lys 
            20                  25                  30          


Gln Lys Glu Glu Gln Lys Lys Leu Glu Glu Leu Asn Met Lys Ala Val 
        35                  40                  45              


Gly Lys Trp Pro Leu Ala Thr Gly Gly Ile Lys Lys Phe Ala Lys Lys 
    50                  55                  60                  

<210>  318
<211>  567
<212>  DNA
<213>  Homo sapiens

<400>  318
atggcctccg gtcggtgggc tcctccaggc ccagcttggg cctcccagcg gcctctgcag     60

acccaagtcg tcctgaagtc ggcctctcca ggcccagctc cggcctcccg gtggcctctc    120

cagcaagcaa tctgttttgg ctcagctcct gcccagctcc cgctggcctt tggaggcccc    180

aaactttctc cagccaagct cttcaggcct acctcctgcc tcccggtggc ctgtacgggc    240

ccagctctgg caggagaaca gcctctgcag gccccgctct tgcctcccag gggcctctcc    300

aggcccagct ctcgccccac ggtggcctcc tggggccaag tccctgcctg cctcccggca    360

gcccgcgagc ggcccagctc ctccctcacg gtggcctgtt taggcccaac tcgtgtctct    420

ggcaccctgt ccagaggcgt gagcccctgc ctcacactgg cctctctcat gctgagagag    480

gtcctccctc acgctggtct gttgaggccc agctcatgcc tctgttggcc tctccaggtc    540

cagcccctgc ctgttggcgg cctctag                                        567


<210>  319
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  319


Met Ala Ser Gly Arg Trp Ala Pro Pro Gly Pro Ala Trp Ala Ser Gln 
1               5                   10                  15      


Arg Pro Leu Gln Thr Gln Val Val Leu Lys Ser Ala Ser Pro Gly Pro 
            20                  25                  30          


Ala Pro Ala Ser Arg Trp Pro Leu Gln Gln Ala Ile Cys Phe Gly Ser 
        35                  40                  45              


Ala Pro Ala Gln Leu Pro Leu Ala Phe Gly Gly Pro Lys Leu Ser Pro 
    50                  55                  60                  


Ala Lys Leu Phe Arg Pro Thr Ser Cys Leu Pro Val Ala Cys Thr Gly 
65                  70                  75                  80  


Pro Ala Leu Ala Gly Glu Gln Pro Leu Gln Ala Pro Leu Leu Pro Pro 
                85                  90                  95      


Arg Gly Leu Ser Arg Pro Ser Ser Arg Pro Thr Val Ala Ser Trp Gly 
            100                 105                 110         


Gln Val Pro Ala Cys Leu Pro Ala Ala Arg Glu Arg Pro Ser Ser Ser 
        115                 120                 125             


Leu Thr Val Ala Cys Leu Gly Pro Thr Arg Val Ser Gly Thr Leu Ser 
    130                 135                 140                 


Arg Gly Val Ser Pro Cys Leu Thr Leu Ala Ser Leu Met Leu Arg Glu 
145                 150                 155                 160 


Val Leu Pro His Ala Gly Leu Leu Arg Pro Ser Ser Cys Leu Cys Trp 
                165                 170                 175     


Pro Leu Gln Val Gln Pro Leu Pro Val Gly Gly Leu 
            180                 185             

<210>  320
<211>  5221
<212>  DNA
<213>  Homo sapiens

<400>  320
atggcgtcct cgggccaggc tccccacctc ggggctgcct ccacacaccc agctgtactc     60

ggcccacagg actgtgtcca gcgaggcctc ccgtggcgtc agcgtgttcg tgtggaggaa    120

tgtggaacct cactctgtgg ccgtgttccc ctggtactcc gtccccttcc tgacccctcc    180

ctggagccac acgaggccca gcaacctgcc agtcactcag tggcctccaa ccagagcaaa    240

caacctgcca agttggcagc tgttgctcat gagcatccac caggtgggac agggagtgtt    300

gaccctgggt ggccccctgg agccacctgc cctgaaagcc cagggcccag aaccccacac    360

actttggggg tggtggaacc tggtaagggc ccacctccca ccatggagga ggagccctgg    420

gcccctcagg ggagtccctg ctggacagcc cagtccctca gtgccctgca caaggaacag    480

gactcatctt ctgagaagga tggatgcagc cccaacaaat gggacaagga ccacatccgg    540

tggcccatga gtggcggtca tgatcttcag caagcggcac caggccctgg cagggcgcac    600

cagggtcacc ccaaccagga caaccggacc gtcagccaga tcctgagcga gcggtggtac    660

accctggggc ccaatgagac gcagaagtac catgacctgg ccttccaggt gaaggtggcc    720

cacttgcaac agggaccaaa agaagtccag ctcagaggct aagcccacaa accaggggct    780

agcaggagta tacaagggct ccacatggcc agtgatgaca tagtgagtga tgaggagcac    840

atggtcatcc atgaggagga gggggtgaca atgtcattgc tgatgatggc tttagcacca    900

ctgacactga tctcaagttc aaggagccac agccgctctc caggcccact atgcacacat    960

cttcccctcc aaggtttgtt ctgcccctgc cctgactccc agccctgagg gggtcctgtc   1020

cccacctcac ctggctcaga ctctgacgct gccctggctg ccccaccact gcctctgccc   1080

aagagtcacc cctgtctgac cccacctcac cctgctcagg ctctggcgca accctggctg   1140

ccctgccact gcctctgccc cagagctggg gcctcgacag cctggctgga aggggacacc   1200

ccagccctgc ctcaacacct gggtccctcc ataactacca caggcagccc tgcagctgtg   1260

ccgggggaaa gctgggcagt ttccctcctc tgagcccctg tacataccat gaagtgtggg   1320

accttcagag cttttcactt ttcggaaaat agctcctgct ggggctacaa gatggagtgt   1380

gaagagggcc ttgggccaca gggaggtgcc tgtggaatag ggggagttca tgcacccctt   1440

ctttctccag aggggctgga ctcagaacag aacacattga tcatgggcga tattttctat   1500

tgtgccaaaa agttgccatg actgtcatta aacctgttta acaccaaata ataaggaaaa   1560

taaaataaaa aattcgggct tggtgcagaa actcactcca aataaattac ctaccaaaat   1620

atttatataa tggtggaaat gttccaaaat tccatatttt gggatttata cacaaaagat   1680

aaaaaaaatt agaggccaag aggctgccgg aagggaaaaa cggggcctgg aaaggccaat   1740

gtgaggaatg agctgggcct aaagaggcca ctggcaggcg ggagctgggc ctgccgaagc   1800

ggccgaaagg caggagcttt ggactgggga ggccacagtg aggcgagagc tagctgggcg   1860

tggagagtct gctgtgattc cgaggccggg cccgtgcagg ccttcgggag gcaggatgcc   1920

gggcctgcaa aagctgactg gagatcaagt tctgggcctg aagaggccgc caaaagtcaa   1980

aagcagggcc tgggaaggct gcctacagcc acgagctggg ctgggctgaa agaggccact   2040

gggaggcagg aggagctgga cctggagagg ctgactcgag gaagttttgc acctggagag   2100

gccgccgaga ggacggagct gggcccgggg aggccaaaat gcagctcttc caggcccact   2160

tccaggccga cttgaggacg acttgggcct gcagagtctg ccaggaggct ggagctggcc   2220

ctggagagcc tgactcaagg gcagtctggg cctgcagagg ccgccagact ggcctctaga   2280

ggctgatgag aggcaggagc tgaccccgga ggggccctcg ttgacgacgc gttgcgcctg   2340

gagaggctgc cgggaggccg gagctgggcc tggagagggc gacttcagga cgatttgggc   2400

cagcagaggc tgccgggagg cccaagctgg gcatagagga atccaccgac tggaggccgt   2460

tcggggcctg gagacgctgt cagagggcag gagctgagcc tggagaggcc accgtgaggc   2520

ctgagctggg gctggggagc ttggcttcag gaagttgtgg gccaaccagg gccaccggga   2580

gctgggcggg agctgagtcc aaagaggttg ttgggaggcc ggagtcgggc ctggagacgc   2640

agccgggagg aagagctgag cccagagagg atgccgggag tctgcaagtg ggtctggaga   2700

ggccgacttc aggaggccca gcctctgcct cccgcatggc agcctctgca agcccagctg   2760

ttcctcctgg ctgcatctcc tcaagtgggc ccagaggttc tgggtcctga gaggcagtcg   2820

gaagggaaaa aatgggcctg gaaaggccgt tgtgaggaat gaaccccatg ggccagaaga   2880

ggccactggc aggtgggagc tgggcctgcc gaagcggcca agaggcagga gctttggact   2940

cgggaggctg cagtgaggcg agagctagct gggcgtggag agtccgctgt gaggcagaga   3000

ctgggcctgt gcaggccttc ggaaggcagg aggccgggcc aggagaggcc gactggaggt   3060

caagttcgga atctgcagag gccgcggaaa gtcaaaagtg gggcctggga aggccaccag   3120

gaggcatgaa ctgggctggg ccaaaagagg ccactgggag acaggaggac ctgggcctgg   3180

agatactgat tcaaactttt gcacctggag aggccgccga gaggccggag ctgggcctgg   3240

ggaggatgat ttgggcctgc agaggccacc gagaggcagg agctgtccct ggacaggcct   3300

acttgatgac agtctgggcc tacagaggcc gccgggaagc aggagctgtc cctggacagg   3360

cctacttgac gacagtctgg tcctgcagag gctgccggga ggaagagctg ggcctggaga   3420

ggccgactgg aggaagtgca ggacctggag cccatgcaaa ggagcaaacg ccaggccggg   3480

agaggccgcc acgacgcatg agcttggcct ccagagggcc tccgtgaggc aggagctggg   3540

cctgcggagg ccgtcccgag gtgggagcct ggcccgagga ggccacggcg aggcaagagg   3600

tgggcctgga gggcacactg ttgaggtaga ggctgggcct ctagtggctg tcaacaggca   3660

ggaggccagg cctggagagg ccgactggtg gtcaagttcg gggcctgcag aggccgcgga   3720

aagtcaaaag cagggcctgg gaaggccacc gggaggcatg agctgggctg ggctgaaaga   3780

ggccactggg agacaggagg agctgagcct ggagagacgg actcgaggaa cttttgcacc   3840

tggagaggcc gccgagaggc cagagctggg cctggggagg cagacttgag gacgacttgg   3900

gccaacagag gccaccggga ggcaggagct gtccttggac aggcctactt gatgacagtc   3960

tgggcctaca gaggccgccg ggaggaagga gctgtccctg gacaggccta cttgacgaca   4020

gtctggtcct gcagaggctg ccgggaggaa gagctgggcc tggagaggcc gactggagga   4080

agtccagggc ctggagccca tgcaaaggag caaacgccag gctgggagag gctgccctga   4140

cgcatgagct tggcctccgg agggccgtga ggcaggagct gggcctgcgg gggctgcccc   4200

aaggcgggag cctggcccga agaggccacg gccaggcaag aggtgggcgt ggagggccca   4260

ctgttgaggt agaggctgga catctagagg ccgccaacag gcaggggctg ggcctggaaa   4320

ggccaacaga ggcatgagct gggtctcaac aggccagcgt gagggaggat tgctctcagc   4380

gtgagagaga ccagtgtgag gcaggggctc atgctgacct ccctcagcgt gagagaggcc   4440

agtgtgagac aggggcccac gctgaactcc ctcagcgtga gagaggccaa tgtgaggcag   4500

gggctcacgc ctctcgaaag ggtgccagag gcatgagttg ggcctgaaca ggccaccgtg   4560

acggaggagc tgggccgcac acaggctgct gggaggcagg cagggacttg gtcccgggag   4620

gccgccgtga ggccagagct gggcctggag atgcccctag gaggcaagag tggggcctgc   4680

agaggctgtt ctccagccag acctgggcct gtacaggcca ccgggaggca ggtgggactg   4740

aggagcatcg ctggagaaag ttcagggtct acaaaagccg gcgggagctg ggcaggagct   4800

gagccaaaag agcttgcttg ctgggaggcc ggagctgggc ctggagaggc tgacttcagg   4860

accacttgag cctgcagagg ccgccgggag gcccaagctg ggcctggaga agcccaccga   4920

cccgaggcca tttggggcct ggagacgccg tcggagggca ggagctgagc caggagaggc   4980

caccatgagg cccgagctgg gcctggggag cttggcttca ggaagctgtg ggccgaccaa   5040

ggccaccagg agctgggcag gcactgagtc caaagaggtt gttgggaggc aggagtcggg   5100

cctgcagacg cagccgggag gaagagctgg gcccggagag gataccggga ggctgcaagt   5160

gggtctggag aggccgactt gaggagcttc tgggcccgga gaggccgccg gaagggaaaa   5220

a                                                                   5221


<210>  321
<211>  1829
<212>  DNA
<213>  Homo sapiens

<400>  321
atgcagccag gaggaacagc tgggcttgca gaggctgcca tgcgggaggc agaggctggg     60

cctcctgaag tcggcctctc cagacccact tgcagactcc cggcatcctc tctgggctca    120

gctcttcctc ccggctgcgt ctccaggccc gactccggcc tcccaacaac ctctttggac    180

tcagctcccg cccagctccc ggtggccctg gttggcccac aacttcctga agccaagctc    240

cccagcccca gctcaggcct cacggtggcc tctccaggct cagctcctgc cctctgacag    300

cgtctccagg ccccgaacgg cctccagtcg gtggattcct ctatgcccag cttgggcctc    360

ccggcagcct ctgctggccc aaatcgtcct gaagtcgccc tctccaggcc cagctccggc    420

ctcccggcag cctctccagg cccaagtcgt cctcaagtcg gcctggaagt gggcctggaa    480

gagctgcatt ttggcctccc cgggcccagc tccgtcctct cggcggcctc tccaggtgca    540

aaacttcctc gagtcagcct ctccaggtcc agctcctcct gcctcccagt ggcctctttc    600

agcccagccc agctcgtggc tgtaggcagc cttcccaggc cctgcttttg acttttggcg    660

gcctcttcag gcccagaact tgatctccag tcagcttttg caggcccggc atcctgcctc    720

ccgaaggcct gcacgggccc ggcctcggaa tcacagcaga ctctccacgc ccagctagct    780

ctcgcctcac tgtggcctcc ccagtccaaa gctcctgcct ttcggccgct tcggcaggcc    840

cagctcccgc ctgccagtgg cctctttagg cccagctcat tcctcacatt ggcctttcca    900

ggccccgttt ttcccttccg gcagcctctt ggcctctaat tttttttatc ttttgtgtat    960

aaatcccaaa atatggaatt ttggaacatt tccaccatta tataaatatt ttggtaggta   1020

atttatttgg agtgagtttc tgcaccaagc ccgaattttt tattttattt tccttattat   1080

ttggtgttaa acaggtttaa tgacagtcat ggcaactttt tggcacaata gaaaatatcg   1140

cccatgatca atgtgttctg ttctggggaa gggggcaaag gcagggtgaa tcactttctt   1200

aaaaagtaca actcaagttg ggagtgcaga gggaattggg agaaaaccct cccgctgcct   1260

gtgtcaaagt gcaggagccc ccacccccat actcacctga gtccagcccc tctggagaaa   1320

gaaggggtgc atgaactccc cctattccac aggcacctcc ctgtggccca aggccctctt   1380

cacactccat cttgtagccc cagcaggagc tattttccga aaagtgaaaa gctctgaagg   1440

tcccacactt catggtatgt acaggggctc agaggaggga aactgcccag ctttcccccg   1500

gcacagctgc agggctaggg ggtatatata agaggagcag gccttggcca ggcgtggtgg   1560

ctcacacctg taatcgcagc actttgggag gtggaggccg gtggatcacg atttcaggag   1620

atcgaaatca gcctggccaa gatggtgaag ccccgtctgt actaaaaata caaaaattag   1680

ccggacgtgg tagcatgcac ctgtaatccc agctacccag aaggctgagg caggagaatg   1740

gcgtgaaccc ggcagtaaga ggttgcagtg agccaagatc tcaccactgc actccagcct   1800

gggtgacaga gcaagactcc gtctcaaaa                                     1829


<210>  322
<211>  5291
<212>  DNA
<213>  Homo sapiens

<400>  322
atggggctca ttcctcacaa cggcctttcc aggcccagtt tttcccttcc ggcggcctct     60

ccgggcccag aagctcctca agtcggcctc tccagaacca cttgcagcct cccggcgtcc    120

tctccgggcc cagctcttcc tcccggctgc gtctacaggc ccgactcctg cctcccaaca    180

acctctttgg actcagtgcc tgcccagctc ctggtggcct tggtcggccc acagcttcct    240

gaagccaagc tcaccgggcc cacctcaggc ctctcggcgg cctctccagg ctcagctcct    300

gccctccgac ggcgtctcca ggtcccaaat ggcctcgggt cggtgggctt ctccaggccc    360

agcttgggcc tcccggcggc ctctgcaggc ccaagtggtc ctgaagtcct gcacttcctg    420

cagtcggcct ctccaggccc agctcttcct cccggcagcc tctgcgggac cagactgtcg    480

tcaagtaggc ctgtccaggg acagctcctg cctcccggca gactctgcag gcccaagtcg    540

tcctcaagtc agcctcccca ggtccagctc ctcctgtctc ccagtggcct ctttcagccc    600

agcccagctc atgcctcccg gcggccttcc caggccccgc ttttgacttt ccgcggcctc    660

tgcaggccgg cctcctgcct cccgacagct tgcacaggcc cagcctctgc ctcacagcgg    720

actctccacg cccagctcgc tctcgcctgc ggcctcccga gtccaaagct ccggcctctc    780

cgccgcttcg gcaggcccag ctcccgcctg ccagtggcct tttcaggccc atggggctca    840

ttcctcacaa cggcctttcc aggcccagtt tttcccttcc ggcggcctct ccgggcccag    900

aagctcctca agtcggcctc tccagaccca cttgcagcct cccggtatcc tctccgggcc    960

cagctcttcc tcccggctgc gtctgcaggc ccgactcctg cctcccaaca acctctttgg   1020

actcagtgcc tgcccagctc ctggtggcct tggtcggccc acagcttcct gaagccaagc   1080

tccccaggcc cagctcgggc ctcatggtgg cctctcctgg ctcagctcct gccctccgac   1140

ggcgtctcca ggccccaaat ggcctcgggt cggtgggctt ctccaggccc agcttgggcc   1200

tcccggcggc ctctgcaggc tcaagtggtc ctgaagtcag cctctccagg cccagctccg   1260

gcctcccagc aagcaagctc ttttggctca gctcctgccc agctcccgcc ggcttttgta   1320

gaccctgaac tttctccagc gatgctcctc agtcccacct gcctcccggt ggcctgtaca   1380

ggcccaggtc tggctggaga acagcctctg caggccccac tcttgcctcc taggggcatc   1440

tccaggccca gctctggcct cacggcggcc tcccgggacc aagtccctgc ctgcctccca   1500

gcagcctgtg tgcggcccag ctcctccgtc acggtggcct gttcaggccc aactcatgcc   1560

tctggcaccc tttcgagagg cgtgagcccc tgcctcacat tggcctctct cacgctgagg   1620

gagttcagcg tgggcccctg tctcacactg gcctctctca cgctgaggga ggtcagcatg   1680

agcccctgcc tcacactggt ctctctcacg ctgagagcaa tcctccctca cgctggcctg   1740

ttgagaccca gctcatgcct ctgttggcct ttccaggccc agcccctgcc tgttggcggc   1800

ctctagatgt ccagcctcta cctcaacagt gggccctcca cgcccacctc ttgcctggcc   1860

gtggcctctt cgggccaggc tcccgccttg gggcagcccc cgcaggccca gctcctgcct   1920

cacggccctc cggaggccaa gctcatgcgt cagggcagcc tctcccagcc tggcgtttgc   1980

tcctttgcat gggctccagg ccctggactt cctccagtcg gcctctccag gcccagctct   2040

tcctcccggc agcctctgca ggaccagact gtcgtcaagt aggcctgtcc agggacagct   2100

ccttcctccc ggcggcctct gtaggcccag actgtcatca agtaggcctg tccaaggaca   2160

gctcctgcct cccggtggcc tctgttggcc caagtcgtcc tcaagtctgc ctccccaggc   2220

ccagctctgg cctctcggcg gcctctccag gtgcaaaagt tcctcgagtc cgtctctcca   2280

ggctcagctc ctcctgtctc ccagtggcct ctttcagccc agcccagctc atgcctcccg   2340

gtggccttcc caggccctgc ttttgacttt ccgcggcctc tgcaggcccc gaacttgacc   2400

accagtcggc ctctccaggc ctggcctcct gcctgttgac agccactaga ggcccagcct   2460

ctacctcaac agtgtgccct ccaggcccac ctcttgcctc gccgtggcct cctcgggcca   2520

ggctcccacc tcgggacggc ctccgcaggc ccagctcctg cctcacggag gccctctgga   2580

ggccaagctc atgcgtcgtg gcggcctctc ccggcctggc gtttgctcct ttgcatgggc   2640

tccaggtcct gcacttcctc cagtcggcct ctccaggccc agctcttcct cccggcagcc   2700

tctgcaggac cagactgtcg tcaagtaggc ctgtccaggg acagctcctg cttcccggcg   2760

gcctctgtag gcccagactg tcatcaagta ggcctgtcca gggacagctc ctgcctctcg   2820

gtggcctctg caggcccaaa tcatcctccc caggcccagc tccggcctct cggcggcctc   2880

tccaggtgca aaagtttgaa tcagtatctc caggcccagg tcctcctgtc tcccagtggc   2940

ctcttttggc ccagcccagt tcatgcctcc tggtggcctt cccaggcccc acttttgact   3000

ttccgcggcc tctgcagatt ccgaacttga cctccagtcg gcctctcctg gcccggcctc   3060

ctgccttccg aaggcctgca caggcccagt ctctgcctca cagcggactc tccacgccca   3120

gctagctctc gcctcactgc agcctcccga gtccaaagct cctgcctctt ggccgcttcg   3180

gcaggcccag ctcccacctg ccagtggcct cttctggccc atggggttca ttcctcacaa   3240

cggcctttcc aggcccattt tttcccttcc gactgcctct caggacccag aacctctggg   3300

cccacttgag gagatgcagc caggaggaac agctgggctt gcagaggctg ccatgcggga   3360

ggcagaggct gggcctcctg aagtcggcct ctccagaccc acttgcagac tcccggcatc   3420

ctctctgggc tcagctcttc ctcccggctg cgtctccagg cccgactccg gcctcccaac   3480

aacctctttg gactcagctc ccgcccagct cccggtggcc ctggttggcc cacaacttcc   3540

tgaagccaag ctccccagcc ccagctcagg cctcacggtg gcctctccag gctcagctcc   3600

tgccctctga cagcgtctcc aggccccgaa cggcctccag tcggtggatt cctctatgcc   3660

cagcttgggc ctcccggcag cctctgctgg cccaaatcgt cctgaagtcg ccctctccag   3720

gcccagctcc ggcctcccgg cagcctctcc aggcgcaacg cgtcgtcaac gagggcccct   3780

ccggggtcag ctcctgcctc tcatcagcct ctagaggcca gtctggcggc ctctgcaggc   3840

ccagactgcc cttgagtcag gctctccagg gccagctcca gcctcctggc agactctgca   3900

ggcccaagtc gtcctcaagt cggcctggaa gtgggcctgg aagagctgca ttttggcctc   3960

cccgggccca gctccgtcct ctcggcggcc tctccaggtg caaaacttcc tcgagtcagc   4020

ctctccaggt ccagctcctc ctgcctccca gtggcctctt tcagcccagc ccagctcgtg   4080

gctgtaggca gccttcccag gccctgcttt tgacttttgg cggcctcttc aggcccagaa   4140

cttgatctcc agtcagcttt tgcaggcccg gcatcctgcc tcccgaaggc ctgcacgggc   4200

ccggcctcgg aatcacagca gactctccac gcccagctag ctctcgcctc actgtggcct   4260

ccccagtcca aagctcctgc ctttcggccg cttcggcagg cccagctccc gcctgccagt   4320

ggcctcttta ggcccagctc attcctcaca ttggcctttc caggccccgt ttttcccttc   4380

cggcagcctc ttggcctcta atttttttta tcttttgtgt ataaatccca aaatatggaa   4440

ttttggaaca tttccaccat tatataaata ttttggtagg taatttattt ggagtgagtt   4500

tctgcaccaa gcccgaattt tttattttat tttccttatt atttggtgtt aaacaggttt   4560

aatgacagtc atggcaactt tttggcacaa tagaaaatat cgcccatgat caatgtgttc   4620

tgttctgggg aagggggcaa aggcagggtg aatcactttc ttaaaaagta caactcaagt   4680

tgggagtgca gagggaattg ggagaaaacc ctcccgctgc ctgtgtcaaa gtgcaggagc   4740

ccccaccccc atactcacct gagtccagcc cctctggaga aagaaggggt gcatgaactc   4800

cccctattcc acaggcacct ccctgtggcc caaggccctc ttcacactcc atcttgtagc   4860

cccagcagga gctattttcc gaaaagtgaa aagctctgaa ggtcccacac ttcatggtat   4920

gtacaggggc tcagaggagg gaaactgccc agctttcccc cggcacagct gcagggctag   4980

ggggtatata taagaggagc aggccttggc caggcgtggt ggctcacacc tgtaatcgca   5040

gcactttggg aggtggaggc cggtggatca cgatttcagg agatcgaaat cagcctggcc   5100

aagatggtga agccccgtct gtactaaaaa tacaaaaatt agccggacgt ggtagcatgc   5160

acctgtaatc ccagctaccc agaaggctga ggcaggagaa tggcgtgaac ccggcagtaa   5220

gaggttgcag tgagccaaga tctcaccact gcactccagc ctgggtgaca gagcaagact   5280

ccgtctcaaa a                                                        5291


<210>  323
<211>  1635
<212>  DNA
<213>  Homo sapiens

<400>  323
tttttccctt ccggcggcct ctccgggccc agaagctctt caagtcggcc tctccagacc     60

cacttgcagc ctcccggcat cctctccggg cccagctctt cctcccggct gcgtctgcag    120

gcccgactcc tgcctcccaa caacctcttt ggactcagtg cctgcccagc tcctggtggc    180

cttggtcggc ccacagcttc ctgaagccaa gctccccggg cccagctcag gcctcacggt    240

ggcctctcca ggctcagctc ctgccctccg acggcgtctc caggccccaa atggcctcgg    300

gtcggtgggc ttctccaggc ccagcttggg cctcccggcg gcctctgcag gctcaagtgg    360

tcctgaagtc agcctctcca ggcccagctc cggcctccca gcaagcaagc tcttttggct    420

cagctcctgc ccagctcccg ccggcttttg tagaccctga actttctcca gcgaagctcc    480

tcagtcccac ctcctgcctc ccggtggcct gtacaggccc aggtctggct ggagaacagc    540

ctctgcaggc ccggctcttg cctcccaggg gcgtctccag gcccagctct ggcctcacgg    600

cggcctcccg ggaccaagtc cctgcctgcc tcccagcagc ctgtgtgcgg cccagctcct    660

ccgtcacggt ggcctgttga ggcccaactc atgcctctgg caccctttcg agaggcgtga    720

gcccctgcct cacattggcc tctctcacgc tgagggaggt cagcgtgagc ccctgcctca    780

cactggcctc tctcacgctg agggaggtca gcgtgtggcc ctgcctcaca ctggcctctc    840

tcacgctgag ggaggtcagc gtgaggccct gcctcacact ggcctctcta acgctgaggg    900

aggtcagcgt gaggccctgc ctcacactgg cctctctaac gctgagagaa gtcctccctc    960

acgctggcct gttgaggccc agttcatgcc tctgttggct tctctaggcc cagcccctgc   1020

ctgtttgcgg cctctagagg cccagcctct acctcaaccg tgggccctcc acgcccacct   1080

cttgcctcgc cgtggcctcc tcggaccagg ctcccgcctt ggggcggccc ccgcaggccc   1140

agctcctgcc tcacggccct ccggaggcca aggtcatgcg tcagggcggc ctctcccggc   1200

ctgtcgtttc ctcctttgca tgggctccag gtcctgcact tcctgcagtc ggcctctcca   1260

ggcccagctc ttcctcccgg cagcctctgc gggaccagac tgtcgtcaag taggcctgtc   1320

cagggacagc tcctgcctcc cggcagactc tgcaggccca agtcgtcctc aagtcagcct   1380

ccccaggccc agctccggcc tctcggcggc ctctccaggt gcaaaagttc ctcgagtccg   1440

tctctccagg tccagctcct cctgtctccc agtggcctct ttcagcccag cccagctcat   1500

gcctcccagc ggccttccca ggccccgctt ttgactttcc gcggcctctg caggccccga   1560

acttgacctc cagtcggcct ctgcaggcct ggcctcctgc ctcccgaaag cttgcacagg   1620

cccagcctct gcctc                                                    1635


<210>  324
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  324


Met Pro Leu Leu Ala Ser Leu Gly Pro Ala Pro Ala Cys Leu Arg Pro 
1               5                   10                  15      


Leu Glu Ala Gln Pro Leu Pro Gln Pro Trp Ala Leu His Ala His Leu 
            20                  25                  30          


Leu Pro Arg Arg Gly Leu Leu Gly Pro Gly Ser Arg Leu Gly Ala Ala 
        35                  40                  45              


Pro Ala Gly Pro Ala Pro Ala Ser Arg Pro Ser Gly Gly Gln Gly His 
    50                  55                  60                  


Ala Ser Gly Arg Pro Leu Pro Ala Cys Arg Phe Leu Leu Cys Met Gly 
65                  70                  75                  80  


Ser Arg Ser Cys Thr Ser Cys Ser Arg Pro Leu Gln Ala Gln Leu Phe 
                85                  90                  95      


Leu Pro Ala Ala Ser Ala Gly Pro Asp Cys Arg Gln Val Gly Leu Ser 
            100                 105                 110         


Arg Asp Ser Ser Cys Leu Pro Ala Asp Ser Ala Gly Pro Ser Arg Pro 
        115                 120                 125             


Gln Val Ser Leu Pro Arg Pro Ser Ser Gly Leu Ser Ala Ala Ser Pro 
    130                 135                 140                 


Gly Ala Lys Val Pro Arg Val Arg Leu Ser Arg Ser Ser Ser Ser Cys 
145                 150                 155                 160 


Leu Pro Val Ala Ser Phe Ser Pro Ala Gln Leu Met Pro Pro Ser Gly 
                165                 170                 175     


Leu Pro Arg Pro Arg Phe 
            180         

<210>  325
<211>  2146
<212>  DNA
<213>  Homo sapiens

<400>  325
atgtggccct gcctcacact ggcctctctc acgctgaggg aggtcagcgt cctgcacttc     60

ctgcagtcgg cctctccagg cccagctctt cctcccggca gcctctgcgg gaccagactg    120

tcgtcaagta ggcctgtcca gggacagctc ctgcctcctg gcagactctg caggcccaag    180

tcgtcctcaa gtcagcctcc ccaggtccag ctcctcctgt ctcccagtgg cctctttcag    240

cccagcccag ctcatgcctc ccggcggcct tcccaggccc cgcttttgac tttccgcggc    300

ctctgcaggc cggcctcctg cctcccgaaa gcttgcacag gcccagcctc tgcctcacag    360

cggactctcc acgcccagct cgctctcgcc tgcggcctcc cgagtccaaa gctccggcct    420

ctccgccgct tcggcaggcc cagctcccgc ctgccagtgg cctcttcagg cccatggggc    480

tcattcctca caacggcctt tcgaggccca gtttttccct tccggcggcc tctccgggcc    540

cagaagctct tcaagtcggc ctctccagac ccacttgcag cctcccggca tcctctccgg    600

gcccagctct tcctcccggc tgcgtctgca ggcccgactc ctgcctccca acaacctctt    660

tggactcagt gcctgcccag ctcctggtgg ccttggtcgg cccacagctt cctgaagcca    720

agctccccgg gcccagctca ggcctcacgg tggcctctcc aggctcagct cctgccctcc    780

gacggcgtct ccaggcccca aatggcctcg ggtcggtggg cttctccagg cccagcttgg    840

gcctcccggc ggcctctgca ggctcaagtg gtcctgaagt cagcctctcc aggcccagct    900

ccggcctccc agcaagcaag ctcttttggc tcagctcctg cccagctccc gccggctttt    960

gtagaccctg aactttctcc agcgaagctc ctcagtccca cctcctgcct cccggtggcc   1020

tgtacaggcc caggtctggc tggagaacag cctctgcagg cccggctctt gcctcccagg   1080

ggcgtctcca ggcccagctc tggcctcacg gcggcctccc gggaccaagt ccctgcctgc   1140

ctcccagcag cctgtgtgcg gcccagctcc tccgtcacgg tggcctgttg aggcccaact   1200

catgcctctg gcaccctttc gagaggcgtg agcccctgcc tcacattggc ctctctcacg   1260

ctgagggagg tcagcgtgag cccctgcctc acactggcct ctctcacgct gagggaggtc   1320

agcgtgtggc cctgcctcac actggcctct ctcacgctga gggaggtcag cgtgaggccc   1380

tgcctcacac tggcctctct aacgctgagg gaggtcagcg tgaggccctg cctcacactg   1440

gcctctctaa cgctgagaga agtcctccct cacgctggcc tgttgaggcc cagttcatgc   1500

ctctgttggc ttctctaggc ccagcccctg cctgtttgcg gcctctagag gcccagcctc   1560

tacctcaacc gtgggccctc cacgcccacc tcttgcctcg ccgtggcctc ctcggaccag   1620

gctcccgcct tggggcggcc cccgcaggcc cagctcctgc ctcacggccc tccggaggcc   1680

aaggtcatgc gtcagggcgg cctctcccgg cctgtcgttt cctcctttgc atgggctcca   1740

ggtcctgcac ttcctgcagt cggcctctcc aggcccagct cttcctcccg gcagcctctg   1800

cgggaccaga ctgtcgtcaa gtaggcctgt ccagggacag ctcctgcctc ccggcagact   1860

ctgcaggccc aagtcgtcct caagtcagcc tccccaggcc cagctccggc ctctcggcgg   1920

cctctccagg tgcaaaagtt cctcgagtcc gtctctccag gtccagctcc tcctgtctcc   1980

cagtggcctc tttcagccca gcccagctca tgcctcccag cggccttccc aggccccgct   2040

tttgactttc cgcggcctct gcaggccccg aacttgacct ccagtcggcc tctgcaggcc   2100

tggcctcctg cctcccgaaa gcttgcacag gcccagcctc tgcctc                  2146


<210>  326
<211>  1635
<212>  DNA
<213>  Homo sapiens

<400>  326
atggggctca ttcctcacaa cggcctttcc aggcccagtt tttcccttcc ggcggcctct     60

ccgggcccag aagctcctca agtcggcctc tccagaccca cttgcagcct cccggcgtcc    120

tctccgggcc cagctcttcc tcccggctgc gtctacaggc ccgactcctg cctcccaaca    180

acctctttgg actcagtgcc tgcccagctc ctggtggcct tggtcggccc acagcttcct    240

gaagccaagc tccccgggcc cagctcaggc ctcacggcgg cctctccagg ctcagctcct    300

gccctccgac ggcgtctcca ggccccaaat ggcctcgggt cgaggcccag cctctacctc    360

aaccgtgggc cctccacgcc cacctcttgc ctcgccgtgg cctcctcgga ccaggctccc    420

gccttggggc ggcccccgca ggcccagctc ctgcctcacg gccctccgga ggccaagctc    480

atgtgtcagg gcggcctctc ccggcctggc gtttgctcct ttgcatgggc tccaggcccc    540

gaacttgacc tccagtcggc ctctgcaggc ctggcctcct gcctcccgaa agcttgcaca    600

ggcccagcct ctgcctcaca gcggactctc cacgcccagc tcgctctcgc ctgcggcctc    660

ccaagtccaa agctccggcc tctccgccgc ttcggcaggc ccagctcccg cctgccagtg    720

gcctcttcag gcccatgggg ctcattcctc acaacggcct ttccaggccc agtttttccc    780

ttccggcggc ctctccgggc ccagaagctc ctcaagtcgg cctctccaga cccacttgca    840

gcctcccggc gtcctctccg ggcccagctc ttcctcccgg ctgcgtctac aggcccgact    900

cctgcctccc aacaacctct ttggactcag tgcctgccca gctcctggtg gccttggtcg    960

gcccacagct tcctgaagcc aagctccccg ggcccagctc aggcctcacg gcggcctctc   1020

caggctcagc tcctgccctc cgacggcgtc tccaggcccc aaatggcctc gggtcggtgg   1080

gcttctccag gcccagcttg ggcctcccgg cggcctctgc aggctcaagt ggtcctgaag   1140

tcagcctctc caggcccagc tccggcctcc gagcaagcaa gctcttttgg ctcagctcct   1200

gcccagctcc cgccggcttt tgtagaccct gaactttctc cagcgaagct cctcagtccc   1260

acctcctgcc tcccggtggc ctgtacaggc ccaggtctgg ctggagaaca gcctctgcag   1320

gccccgctct tgcctcccag gggcgtctcc aggcccagct ctggcctcac ggcggcctcc   1380

cgggaccaag tccctgcctg cctcccagca gccagtgtgc ggcccagctc ctccgtcacg   1440

gtggcctgtt gaggcccaac tcatgcctct ggcacccttt cgagaggcgt gagcccctgc   1500

ctcacattgg cctctctcac gctgagggag gtcagcgtga gcccctgcct cacactggcc   1560

tctctcacgc tgagggaggt cagcgtgagc ccctgcctca cactggcctc tctcacgctg   1620

agggaggtca gcgtg                                                    1635


<210>  327
<211>  650
<212>  DNA
<213>  Homo sapiens

<400>  327
atgcctctgt tggcttctcc aggcccagcc cctgcctgtt ggcggcctct agaggcccag     60

cctctacctc aaccgtgggc cctccacgcc cacctcttgc ctcgccgtgg cctcctcgga    120

ccaggctccc gccttggggc ggcccccgca ggcccagctc ctgcctcacg gccctccgga    180

ggccaagctc atgtgtcagg gcggcctctc ccggcctggc gtttgctcct ttgcatgggc    240

tccaggtcct gcacttcctg cagtcggcct ctccaggccc agctcttcct cccggcagcc    300

tctgcgggac cagactgtcg tcaagtaggc ctgtccaggg acagctcctg cctcccggca    360

gactctgcag gcccaagtcg tcctcaagtc agcctcccca ggcccagctc cggcctctcg    420

gcggcctctc caggtgcaaa agttcctcga gtccgtctct ccaggtccag ctcctcctgt    480

ctcccagtgg cctctttcag cccagcccag ctcatgcctc ccggcggcct tcccaggccc    540

cgcttttgac tttccgcggc ctctgcaggc cccgaacttg acctctagtc ggcctctgca    600

ggcctggcct cctgcctccc gaaagcttgc acaggcccag cctctgcctc               650


<210>  328
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  328


Met Pro Leu Leu Ala Ser Pro Gly Pro Ala Pro Ala Cys Trp Arg Pro 
1               5                   10                  15      


Leu Glu Ala Gln Pro Leu Pro Gln Pro Trp Ala Leu His Ala His Leu 
            20                  25                  30          


Leu Pro Arg Arg Gly Leu Leu Gly Pro Gly Ser Arg Leu Gly Ala Ala 
        35                  40                  45              


Pro Ala Gly Pro Ala Pro Ala Ser Arg Pro Ser Gly Gly Gln Ala His 
    50                  55                  60                  


Val Ser Gly Arg Pro Leu Pro Ala Trp Arg Leu Leu Leu Cys Met Gly 
65                  70                  75                  80  


Ser Arg Ser Cys Thr Ser Cys Ser Arg Pro Leu Gln Ala Gln Leu Phe 
                85                  90                  95      


Leu Pro Ala Ala Ser Ala Gly Pro Asp Cys Arg Gln Val Gly Leu Ser 
            100                 105                 110         


Arg Asp Ser Ser Cys Leu Pro Ala Asp Ser Ala Gly Pro Ser Arg Pro 
        115                 120                 125             


Gln Val Ser Leu Pro Arg Pro Ser Ser Gly Leu Ser Ala Ala Ser Pro 
    130                 135                 140                 


Gly Ala Lys Val Pro Arg Val Arg Leu Ser Arg Ser Ser Ser Ser Cys 
145                 150                 155                 160 


Leu Pro Val Ala Ser Phe Ser Pro Ala Gln Leu Met Pro Pro Gly Gly 
                165                 170                 175     


Leu Pro Arg Pro Arg Phe 
            180         

<210>  329
<211>  1254
<212>  DNA
<213>  Homo sapiens

<400>  329
atgggctcca ggcctgtcca gggacagctc ctgcctcccg gcagactctg caggcccaag     60

tcgtcctcaa gtcagcctcc ccaggtccag ctcctcctgt ctcccagtgg cctctttcag    120

cccagcccag ctcatgcctc ccggcggcct tcccaggccc cgcttttgac tttccgcggc    180

ctctgcaggc cggcctcctg cctcccgaca gcttgcacag gcccagcctc tgcctcacag    240

cggactctcc acgcccagct cgctctcgcc tgcggcctcc ctagtccaaa gctccggcct    300

ctccgccgct tccgcaggcc cagctcccgc ctgccagtgg cctcttcagg cccatggggc    360

tcattcctca caacggcctt tccaggccca gtttttccct tccggcggcc tctccgggcc    420

cagaagctcc tcaagtcggc ctctccagac ccacttgcag cctcccggcg tcctctccgg    480

gcccagctct tcctcccggc tgcgtctaca ggcccgactc ctgcctccca acaacctctt    540

tggactcagt gcctacccag ctcctggtgg ccttggtcgt gccacagctt cctgaagcca    600

agctccccgg gcccagctca ggcctcacgg cggcctctcc aagctcagct cctgccctcc    660

gacggcgtct ccaggcccca aatggcctcg ggtcggtggg cttctccagg cccagcttgg    720

gcctcccggc ggcctctgca ggctcaagtg gtcctgaagt cagcctctcc aggcccagtt    780

ctggcctccc agcaagcaag ctcttttggc tcagctcctg cccagctccc gccggctttt    840

gtagaccctg aactttctcc agcgaagctc ctcagtccca cctcctgcct cccggtggcc    900

tgtacaggcc caggtctggc tggagaacag cctctgcagg ccccgctctt gcctcccagg    960

ggcgtctcca ggcccagctc tggcctcacg gcggcctccc gggaccaagt ccctgcctgc   1020

ctcccagcag cctgtgtgcg gcccagctcc tccgtcacgg tggcctgttg aggcccaact   1080

catgcctctg gcaccctttc aagaggcgtg agcccctgcc tcacattggc ctctctcacg   1140

ctgagggagg tcagcgtgag cccctgcctc acactggcct ctctcacgct gagggaggtc   1200

agcgtgagcc cctgcctcac actggcctct ctcacgctga gggaggtcag cgtg         1254


<210>  330
<211>  1542
<212>  DNA
<213>  Homo sapiens

<400>  330
ccttccggcg gcctctccgg gcccagaagc tcctcaagtc ggcctctcca gacccacttg     60

cagcctcccg gcgtcctctc cgggcccagc tcttcctccc ggctgcgtct gcaggcccga    120

ctcctgcctc ccaacaacct ctttggactc tgcctgccca gctcctggtg gccttggtcg    180

gcccacagct tcctgaagcc aagctcccca ggcccagctc aggcctcacg gtggcctctc    240

caggctcagc tcctgccctc cgacggcgtc tccaggcccc aaatggcctc gggtcggtgg    300

gcttctccag gcccagcttg ggcctcccgg cggcctctgc aggctcaagt ggtcctgaag    360

tcagcctctc caggcccagt tccggcctcc cagcaagcaa gctcttttgg ctcagctcct    420

gctcagctcc tgcccagctc ccgccggctt ttgtagaccc tgaactttct ccagcgaagc    480

tcctcagtcc cacctcctgc ctcccggtgg cctgtacagg cccaggtctg gctggagaac    540

agcctctgca ggccccgctc ttgcctccca ggggcgtctc caggcccagc tctggcctca    600

cggcggcctc ccgggaccaa gtccctgcct gcctcccagc agcctgtgtg cggcccagct    660

cctccgtcac ggtggcctgt tcaggcccaa ctcatgcctc tggcaccctt tcgagaggcg    720

tgagcccctg cctcacattg gcctctctca cgctgaggga ggtcagcgtg aggccctgcc    780

tcacactggc ctctctaacg ctgagggagg tcagcgtgag gccctgcctc acactggcct    840

ctctcacgct gagagaagtc ctccctcacg ctggcctgtt gaggcccagt tcatgcctct    900

gttggcttct ccaggcccag cccctgcctg ttggcggcct ctagaggccc agcctctacc    960

tcaaccgtgg gccctccacg cccacctctt gcctcgccgt ggcctcctcg gaccaggctc   1020

ccgccttggg gcggcccccg caggcccagc tcctgcctca cggccctccg gaggccaagc   1080

tcatgtgtca gggcggcctc tcccggcctg gcgtttgctc ctttgcatgg gctccaggtc   1140

ctgcacttcc tgcagtcggc ctctccaggc ccagctcttc ctcccggcag cctctgcggg   1200

accagactgt cgtcaagtag gcctgtccag ggacagctcc tgcctcccgg cagactctgc   1260

aggcccaagt cgtcctcaag tcagcctccc caggcccagc tccggcctct cggtggcctc   1320

tccaggtgca aaacttcctc gagtccgtct ctccaggtcc agctcctcct gtctcccagt   1380

ggcctctttc agcccagccc agctcatgcc tcccggcggc cttcccaggc cccgcttttg   1440

actttccgcg gcctctgcag gccccgaact tgacctctag tcggcctctg caggcctggc   1500

ctcctgcctc ccgacagctt gcacaggccc agcctctgcc tc                      1542


<210>  331
<211>  650
<212>  DNA
<213>  Homo sapiens

<400>  331
atgcctctgt tggcttctcc aggcccagcc cctgcctgtt ggcggcctct agaggcccag     60

cctctacctc aacagtgggc cctccacgcc cacctgttgc cttgccgtgg cgtcctcggg    120

ccaggctccc gccttggggc ggcccccgca ggcccagctc ctgcctcacg gccctccgga    180

ggccaagctc atgcgtcaga gcggcctctc ccggcctggc gtttgctcct ttgcatgggc    240

tccaggtcct gcacttcctc cagtcggcct ctccaggccc agcgcttcct cccggcagcc    300

tctgcaggac cagactgtcg tcaagtaggc ctgtccaggg acagctcctg cctcccggca    360

gactctgcag gcccaagtcg tcctcaagtc agcctcccca ggcccagctc cggcctctcg    420

gcggcctctc caggtgcaaa agttcctcga gtccgtctct ccaggtccag ctcctcctgt    480

ctcccagtgg cctctttcag cccagcccag ctcatgcctc ccggcgacct tcccaggccc    540

cgcttttgac tttccgcgac ctctgcaggc cccgaaattg acctccagtc ggcctctgca    600

ggcctggtct cctgcctccc gaaagcttgc acaggcccat cctctgcctc               650


<210>  332
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  332


Met Pro Leu Leu Ala Ser Pro Gly Pro Ala Pro Ala Cys Trp Arg Pro 
1               5                   10                  15      


Leu Glu Ala Gln Pro Leu Pro Gln Gln Trp Ala Leu His Ala His Leu 
            20                  25                  30          


Leu Pro Cys Arg Gly Val Leu Gly Pro Gly Ser Arg Leu Gly Ala Ala 
        35                  40                  45              


Pro Ala Gly Pro Ala Pro Ala Ser Arg Pro Ser Gly Gly Gln Ala His 
    50                  55                  60                  


Ala Ser Glu Arg Pro Leu Pro Ala Trp Arg Leu Leu Leu Cys Met Gly 
65                  70                  75                  80  


Ser Arg Ser Cys Thr Ser Ser Ser Arg Pro Leu Gln Ala Gln Arg Phe 
                85                  90                  95      


Leu Pro Ala Ala Ser Ala Gly Pro Asp Cys Arg Gln Val Gly Leu Ser 
            100                 105                 110         


Arg Asp Ser Ser Cys Leu Pro Ala Asp Ser Ala Gly Pro Ser Arg Pro 
        115                 120                 125             


Gln Val Ser Leu Pro Arg Pro Ser Ser Gly Leu Ser Ala Ala Ser Pro 
    130                 135                 140                 


Gly Ala Lys Val Pro Arg Val Arg Leu Ser Arg Ser Ser Ser Ser Cys 
145                 150                 155                 160 


Leu Pro Val Ala Ser Phe Ser Pro Ala Gln Leu Met Pro Pro Gly Asp 
                165                 170                 175     


Leu Pro Arg Pro Arg Phe 
            180         

<210>  333
<211>  650
<212>  DNA
<213>  Homo sapiens

<400>  333
atgcctctgt tggcttctcc aggcccagcc cctgcctgtt ggcgccctct agaggcccag     60

cctctacctc aagagtgggc cctccacgcc cacctcttgc ctcgccgtgg cctcctcgga    120

ccaggctccc gccttggggc ggcccccgca ggcccagctc ctgcctcacg gccctccgga    180

ggccaagctc atgcgtcagg gcggcctctc ccggcctggc gtttgctcct ttgcatgggc    240

tccaggtcct gcacttcctc cagtcggcct ctccaggccc agctcttcct cccggcagcc    300

tctgcgggac cagactgtcg tcaagtaggc ctgtccaggg acagctcctg cctcccggca    360

gactctgcag gcccaagtcg tcctcaagtc agcctcccca ggcccagctc cggcctctcg    420

gcggcctctc caggtgcaaa acttcctcga gtccgtctct ccaggtccag ctcctcctgt    480

ctcccagtgg cctctttcag cccagcccag ctcatgcctc ccggcggcct tcccaggccc    540

cgcttttgac tttccgcggc ctctgcaggc cccgaacttg acttccattc ggcctctgca    600

ggcctggcct cctgcctccc gaaagcttgc acaggcccat cctctgcctc               650


<210>  334
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  334


Met Pro Leu Leu Ala Ser Pro Gly Pro Ala Pro Ala Cys Trp Arg Pro 
1               5                   10                  15      


Leu Glu Ala Gln Pro Leu Pro Gln Glu Trp Ala Leu His Ala His Leu 
            20                  25                  30          


Leu Pro Arg Arg Gly Leu Leu Gly Pro Gly Ser Arg Leu Gly Ala Ala 
        35                  40                  45              


Pro Ala Gly Pro Ala Pro Ala Ser Arg Pro Ser Gly Gly Gln Ala His 
    50                  55                  60                  


Ala Ser Gly Arg Pro Leu Pro Ala Trp Arg Leu Leu Leu Cys Met Gly 
65                  70                  75                  80  


Ser Arg Ser Cys Thr Ser Ser Ser Arg Pro Leu Gln Ala Gln Leu Phe 
                85                  90                  95      


Leu Pro Ala Ala Ser Ala Gly Pro Asp Cys Arg Gln Val Gly Leu Ser 
            100                 105                 110         


Arg Asp Ser Ser Cys Leu Pro Ala Asp Ser Ala Gly Pro Ser Arg Pro 
        115                 120                 125             


Gln Val Ser Leu Pro Arg Pro Ser Ser Gly Leu Ser Ala Ala Ser Pro 
    130                 135                 140                 


Gly Ala Lys Leu Pro Arg Val Arg Leu Ser Arg Ser Ser Ser Ser Cys 
145                 150                 155                 160 


Leu Pro Val Ala Ser Phe Ser Pro Ala Gln Leu Met Pro Pro Gly Gly 
                165                 170                 175     


Leu Pro Arg Pro Arg Phe 
            180         

<210>  335
<211>  1249
<212>  DNA
<213>  Homo sapiens

<400>  335
atggcgactt ttccaggcac agcttttgcc ttttgcagcc tgtccaggcc cagaatgtgc     60

ttaactcggc atcgccagga caagctcatc ctcccggccc agtttttccc ttccggcggc    120

ctctccgggc ccagaagctc ctcaagtccc gaacttgacc tccagtcggc ctctccaggc    180

ccggcctcct gcctcccgaa ggcttgcaca ggcccagcct ctgcctcaca gcggactctc    240

cacgcccagc tcgctctcgc ctcactgcgg cctcccgagt ccaaagctcc ggcctctccg    300

ccgcttcggc aggctcaact gccgcctgcc agtggcctct tcagccccat ggggctcatt    360

cctcacaacg gcctttccag gcccagtttt tcccttccgg cggcctctcc gggcccagaa    420

gctcctcaag tcggcctctc cagacccact tgcagcctcc cggcgtcctc ttcgggccca    480

gctcttcctc ctggctacat ctacaggccc gactcctgcc tcccaacaac ctctttggac    540

tcagtgcctg cccagctcct ggtggccttg gtcggcccac agcttcctga agccaagctc    600

cccgggccca gctcaggcct cacggtggcc tctccaggct cacctcctgc cctccgacgg    660

cgtctccagg ccccaaatgg cctcgggtcg gtgggcttct ccaggcccag cttgggcctc    720

ccggcggcct ctgcaggctc aagtggtcct gaagtcagcc tctccaggcc cagctccggc    780

ctcccagcaa gcaagctctt ttggctcagc tcctgcccag ctcccgccgg cttttgtaga    840

ccctgaactt tctccagcga agctcctcag tcccacctcc tgcctcccgg tggcctgtac    900

aggcccaggt ctggctggag aacagcctct gcaggccccg ctcttgcctc gcaggggcat    960

ctccaggccc agctctggcc tcacggcggc ctcccgggac gaagtccctg cctgcctccc   1020

agcggcctgt gtgcggccca gctcctccgt cacggtggcc tgttgacgcc caactcatgc   1080

ctctggcacc ctttcgagag gcgtgagccc ctgcctcaca ctggcctctc tcacgctgag   1140

ggaggtcagc ttgagcccct gcctcacact ggcctctctc acgctgaggg aggtcagcgt   1200

gagcccctgc ctcacactgg cctgtctcac gctgagggag gtcagcgtg               1249


<210>  336
<211>  281
<212>  PRT
<213>  Homo sapiens

<400>  336


Met Ala Thr Phe Pro Gly Thr Ala Phe Ala Phe Cys Ser Leu Ser Arg 
1               5                   10                  15      


Pro Arg Met Cys Leu Thr Arg His Arg Gln Asp Lys Leu Ile Leu Pro 
            20                  25                  30          


Ala Gln Phe Phe Pro Ser Gly Gly Leu Ser Gly Pro Arg Ser Ser Ser 
        35                  40                  45              


Ser Pro Glu Leu Asp Leu Gln Ser Ala Ser Pro Gly Pro Ala Ser Cys 
    50                  55                  60                  


Leu Pro Lys Ala Cys Thr Gly Pro Ala Ser Ala Ser Gln Arg Thr Leu 
65                  70                  75                  80  


His Ala Gln Leu Ala Leu Ala Ser Leu Arg Pro Pro Glu Ser Lys Ala 
                85                  90                  95      


Pro Ala Ser Pro Pro Leu Arg Gln Ala Gln Leu Pro Pro Ala Ser Gly 
            100                 105                 110         


Leu Phe Ser Pro Met Gly Leu Ile Pro His Asn Gly Leu Ser Arg Pro 
        115                 120                 125             


Ser Phe Ser Leu Pro Ala Ala Ser Pro Gly Pro Glu Ala Pro Gln Val 
    130                 135                 140                 


Gly Leu Ser Arg Pro Thr Cys Ser Leu Pro Ala Ser Ser Ser Gly Pro 
145                 150                 155                 160 


Ala Leu Pro Pro Gly Tyr Ile Tyr Arg Pro Asp Ser Cys Leu Pro Thr 
                165                 170                 175     


Thr Ser Leu Asp Ser Val Pro Ala Gln Leu Leu Val Ala Leu Val Gly 
            180                 185                 190         


Pro Gln Leu Pro Glu Ala Lys Leu Pro Gly Pro Ser Ser Gly Leu Thr 
        195                 200                 205             


Val Ala Ser Pro Gly Ser Pro Pro Ala Leu Arg Arg Arg Leu Gln Ala 
    210                 215                 220                 


Pro Asn Gly Leu Gly Ser Val Gly Phe Ser Arg Pro Ser Leu Gly Leu 
225                 230                 235                 240 


Pro Ala Ala Ser Ala Gly Ser Ser Gly Pro Glu Val Ser Leu Ser Arg 
                245                 250                 255     


Pro Ser Ser Gly Leu Pro Ala Ser Lys Leu Phe Trp Leu Ser Ser Cys 
            260                 265                 270         


Pro Ala Pro Ala Gly Phe Cys Arg Pro 
        275                 280     

<210>  337
<211>  333
<212>  DNA
<213>  Homo sapiens

<400>  337
atgcccacac tgagtgtgta tggacagact tcaggtgtct tctatcaggg cgcgacttcg     60

gtgacgtctc agaggcgcgc cttcgacaac gtcatacacg ctggccttcc gcgacgccac    120

agacgcgcgc tttcagcgac gtcacagggg cgatatagta cctggagctg gggcattagc    180

agtatggtca ggtgctgcat ccacaagccc acgagccagg agcctgctgt gaaggtcatc    240

gacgtcacca gtggaagcag cttcaccccc gaggaggtgc aggagctgca agaagccaca    300

ctgaaggagg ttgacatcct gcacaaggtc taa                                 333


<210>  338
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  338


Met Pro Thr Leu Ser Val Tyr Gly Gln Thr Ser Gly Val Phe Tyr Gln 
1               5                   10                  15      


Gly Ala Thr Ser Val Thr Ser Gln Arg Arg Ala Phe Asp Asn Val Ile 
            20                  25                  30          


His Ala Gly Leu Pro Arg Arg His Arg Arg Ala Leu Ser Ala Thr Ser 
        35                  40                  45              


Gln Gly Arg Tyr Ser Thr Trp Ser Trp Gly Ile Ser Ser Met Val Arg 
    50                  55                  60                  


Cys Cys Ile His Lys Pro Thr Ser Gln Glu Pro Ala Val Lys Val Ile 
65                  70                  75                  80  


Asp Val Thr Ser Gly Ser Ser Phe Thr Pro Glu Glu Val Gln Glu Leu 
                85                  90                  95      


Gln Glu Ala Thr Leu Lys Glu Val Asp Ile Leu His Lys Val 
            100                 105                 110 

<210>  339
<211>  749
<212>  DNA
<213>  Homo sapiens

<400>  339
acagcctcct cttgtaaata gagagtacaa aggctcctcc gagtagtgtg tatgccgggc     60

agacgctgat gccacgggga gaggccttag aaggagcata ggaaagtccc aggtaagaac    120

tagcacaggc tgccatgggc tctgtcggga gccagtgcct tgaggagccc agtgtggcag    180

gcacaccaga cccgggcata gtgatgagcg tcaccttcga cagtcaccag ctggaggagg    240

cggcggaggc ggctcagggc cagggcctta gggccagggg cgtcccagct ttcacggata    300

ccacattgga ggagccagtg cccaatgacc gctatcacgc catctacttt gcgatgctgc    360

tgtctggcgt gggcttcctg ctgccataca acagcttcat cacggacgtg gactacctgc    420

atcacaagta cccagggact tccattgtgt ttgacatgag cctcacctac atcttggtgg    480

cgctggcagc cgtgctcctg aacaacgtcc tggtggagag actgaccctg cacaccagga    540

tcaccgcaag ctacctctta gccttgggcc ctctcctttt tatcagcatc tgtgacgtgt    600

ggctgcagct cttctctcgg gaccaggcct acgccatcaa cctggctgct gtgggcaccg    660

tggccttcgg ctgcacaggg cacactggct ggtgttccta ctgctctgtg tcaaatctct    720

ctgccattaa tgatgttaat ggctgttga                                      749


<210>  340
<211>  204
<212>  PRT
<213>  Homo sapiens

<400>  340


Met Gly Ser Val Gly Ser Gln Cys Leu Glu Glu Pro Ser Val Ala Gly 
1               5                   10                  15      


Thr Pro Asp Pro Gly Ile Val Met Ser Val Thr Phe Asp Ser His Gln 
            20                  25                  30          


Leu Glu Glu Ala Ala Glu Ala Ala Gln Gly Gln Gly Leu Arg Ala Arg 
        35                  40                  45              


Gly Val Pro Ala Phe Thr Asp Thr Thr Leu Glu Glu Pro Val Pro Asn 
    50                  55                  60                  


Asp Arg Tyr His Ala Ile Tyr Phe Ala Met Leu Leu Ser Gly Val Gly 
65                  70                  75                  80  


Phe Leu Leu Pro Tyr Asn Ser Phe Ile Thr Asp Val Asp Tyr Leu His 
                85                  90                  95      


His Lys Tyr Pro Gly Thr Ser Ile Val Phe Asp Met Ser Leu Thr Tyr 
            100                 105                 110         


Ile Leu Val Ala Leu Ala Ala Val Leu Leu Asn Asn Val Leu Val Glu 
        115                 120                 125             


Arg Leu Thr Leu His Thr Arg Ile Thr Ala Ser Tyr Leu Leu Ala Leu 
    130                 135                 140                 


Gly Pro Leu Leu Phe Ile Ser Ile Cys Asp Val Trp Leu Gln Leu Phe 
145                 150                 155                 160 


Ser Arg Asp Gln Ala Tyr Ala Ile Asn Leu Ala Ala Val Gly Thr Val 
                165                 170                 175     


Ala Phe Gly Cys Thr Gly His Thr Gly Trp Cys Ser Tyr Cys Ser Val 
            180                 185                 190         


Ser Asn Leu Ser Ala Ile Asn Asp Val Asn Gly Cys 
        195                 200                 

<210>  341
<211>  2220
<212>  DNA
<213>  Homo sapiens

<400>  341
atggaggatg gtcgctgtga gtgtccggtg atggctggaa cccagagctt catgccaggc     60

ccagaggctg ctggtcttga ggctgggcac gtgcagaccg tgcactcgcc agacatatac    120

cgtgtggtgg tggagggtga gcgtgggaac cagccccaca tctactgtct ggaggagttg    180

ctgcaggagg tgatcatcga tgtgaggcca gctgccactc gcttcttgcc acaagggacc    240

aggattgcag cctactggag ccagcagtac cgctgtctct acccaggcac cgtggtctga    300

gggttactgg acctggagga ggatggggac ttgaccaccg tggagtctga caacggagac    360

acgggcagga tccccctctc acatatccgc ctcctgcccc ctgactataa gatccaatgt    420

gctgagccat ccccggccct cctggtgcca agtgccaagc gccgcagccg gaagaccagc    480

aaagacactg gggagggcaa agacggtggc acggctgggt cggaggagcc aggagccaag    540

gcccgtgggc gtgggtggaa acccagcgcc aaggccaggg gtgacagagc ttctaccctg    600

gaggaaggga acccaacaga cgaagtcccc agtaccccct tagccctgga gccaagcagc    660

accccaggtt ccaagaagag ccccccagag cctgtggaca agcgagccaa ggcccccaag    720

gtgcgccggg cactgccgca gcccagtccc gcaccacccg ccttcaccag ctgcccagca    780

cccgagccat ttgtggagct gccagctcct gccaccaccc tggccccagc acccctcatc    840

accatgcctg ccacacgccc caagcccaag aaggcgcggg cagccgagga gtcgggtgcc    900

aagggccctc ggaggccggg ggaggaggcc gagctgcttg tcaaactgga tcacgggggt    960

gtcatgtcac ccaaaagcaa gaaggctaaa gaggccctgc tgctccggga ggatccgggg   1020

gcggggggct ggcaggagcc caagagcctc ctgagcctgg gcagctatca cccggcggcc   1080

ggcagcagcg agcccaaggc accctggccc aaggccacca accgggacct cgcccaggaa   1140

cccgggccgg ggctcacgtt cgaggactct gggaacccca agagcccgga caaggcccag   1200

gctgagcagg acggggccga agagtccgag agcagcagca gcagcagcag tggctcggag   1260

acagaagggg aggaggaagg cgacaagaac ggggacgggg gctgcggcgc cgggggccgt   1320

ggcgccgggg gccatgagga ctcttcctgc agctcggacg atgaggcagc ccccgccccc   1380

acggctggcc cttctgcgca ggcggcgctc cccaccaagg ccaccaagca ggccggcaag   1440

gcgcggccct cggcccactc cccaggcaag aagacgcccg cgccccagcc ccaggcgcct   1500

cctccgcagc ccacacagcc tctgcagccc aaggctcagg ccggggccaa gagccgaccc   1560

aagaagagag agggcgtcca cctccccacc accaaggagc tggccaagcg gcagcacctg   1620

ccgtccgtgg agaaccggcc caagattgat gccttcctgc cagcctggca gctctggaag   1680

tggttcggca agcccaccca gcagcgtggc atgaagggca aggcccacaa gctcttctac   1740

aaggccatcg tgtgcggcaa ggagatgatc cgtactgggg actgtgccgt gttcctctct   1800

gccggccgcc ccaacctgcc ctacatcggc tgcatccaga gcatgtggga gtcgtggggc   1860

aacaacatgg tggtccgcgt caagtggttc taccaccccg aggagaccag cccaggcaag   1920

cagttccacc agggccagca ctgggaccag aagtccagcc gcagcctccc ggcggccctg   1980

caggtctcca gccagaggaa ggacttcatg gagtgcgcgc tataccagtc ctcgcatgtg   2040

gacgaaaatg acgtgcagac ggtgtcgcac aagtgcctgg tggtgggcct ggagcagtat   2100

gcgcagatgc tgaagaccaa gaagtaccag gacagcgagg gcctgtacta cctcgcgggc   2160

acctacgagc ccaccacagg catgatcttt tccacggatg gcatgcccgt gctctgctga   2220


<210>  342
<211>  2143
<212>  DNA
<213>  Homo sapiens

<400>  342
atgcagctgg accactcatt gcccccggcc cactgtgcac gctccccagg cactgcgggc     60

gtgatgatct ctctgagccg catcctcacg gagctactgc tgcccgacga gcgcgccagc    120

atgctcatct tcttcctggt gtcggtggcg ctggagctgc tgtgcttcct gctgcacctg    180

ttagtgcggt gcagtggctt cgtgctcttc tataccacac ggccgcgcga cagccgccgg    240

ggcaggccag gcctgggcag gggctctggc taccgcgtgc accacgacgt cgtcgccggg    300

gacgtccact tcgagcaccc agccccggcc ctggccccca acgggtcccc aaaggacagc    360

ccagcccatg aggtgaccgg cagcggcggg gcctacatgt gctttgacgt actgtggcca    420

agggtccagc gcagctggcc caccttcaga gccgtgttac tgcaccgcta cgtggtggca    480

ggggtgatct gggccgacat gctctccatc gccgtgacct acttcatcac gctgtgcctg    540

ttccccgacc ttgagtctga gatctgccac tgcatcctgg gcgagtggct gcccatcctc    600

atcatggctg tgttcaacct gtcagacttc gtgggcaaga tcctggcagc cctgcctgtg    660

gactggcggg gcacccacct gctggcctgc tcctgcctgc gtgtggtctt catccccctc    720

ttcaccctgt gcgtctaccc cagcggcatg cccgccctcc gccaccccgc ctggccctgc    780

attttctcac tgctcatggg catcagcaac ggctccttcg gcagcgtgcc catgatcttg    840

gcagcaggca aagtgagccc caagcagcgg gagccggcag ggaacaccat gactgtgtcc    900

tacgtgtcag ggctgacact ggggtccgcc gtggcctact gcacctacag cctcacccgc    960

gatgcccacg gcagctgcct gcacgcctcc accgccaatg gctccatcct cacaggcctc   1020

tgagccagcc ccgcccactg ccagggacac cgagggcctg accaggggcc ccgaggcctg   1080

agggcccctc ccccatcccc acctcagtgc ctgcggggcc ctgagcctcc ccctgtgcca   1140

gcagcaccac tccctcaggg tctagccatc ccccaccctg gactgaagtt ctgcaaagtc   1200

ctttgaggac cagaacacgt ttctgcgacc cggggctctg gccagcactc tgttctgtgt   1260

ttggtctcat acctgcgtct accttctatc tgtgtccagc ggccccagct ccagcccagc   1320

cagcactctg cagggtcaca cgcaccatgt caccacccag gacagcagac acccgccaga   1380

gtgtgcgtgc ccagtgactg caccccggcc ctcatcaccc gctggcactg atcagggcac   1440

cacctggccc agcctccatc agggacccct cctcatgaac cctggagccc tgagaggaga   1500

ggggcagtcc cccaccttgt caccctcagg gcttcccctt ctgtcctcat tcttagagac   1560

tgcttctccc aaacaaaaca cgttagccat gaaggagtcg gagccctggg tccgaatgga   1620

cccgcctgca gtctgcgtca gcctctggga aaccacagcg gtgatgccag ctgggcacgt   1680

caggacctcc ccacacaccc acgtgatgcc acaggtcggg ggatgtgcct gactagggag   1740

ccctcctatt gccttcctgg cccgggatag aagaggggag gtaagtctgg gggcttcgaa   1800

gccgggcccc ccaccctggc tgaagtcagc ttgacctagg tcttgaccct catccagcaa   1860

gggacccgac agacccaagg gtccctagaa tgtaaggagg ggttgggggt cactccagcc   1920

cgggcctccc agaacaccag gcccgtgtgg gtggcaccct gagttcaggg aatcctaagg   1980

gtatccttcc agagacggcg tttccagggg ggaggaccgc ccacccttcc agatccccgg   2040

ccccggctgt gactgccctg tttcacccct gctgtgtccc gtcacccgtc tgtccactaa   2100

ctgtaccaca ccagccatta aaagatgaag gcagacggct gca                     2143


<210>  343
<211>  340
<212>  PRT
<213>  Homo sapiens

<400>  343


Met Gln Leu Asp His Ser Leu Pro Pro Ala His Cys Ala Arg Ser Pro 
1               5                   10                  15      


Gly Thr Ala Gly Val Met Ile Ser Leu Ser Arg Ile Leu Thr Glu Leu 
            20                  25                  30          


Leu Leu Pro Asp Glu Arg Ala Ser Met Leu Ile Phe Phe Leu Val Ser 
        35                  40                  45              


Val Ala Leu Glu Leu Leu Cys Phe Leu Leu His Leu Leu Val Arg Cys 
    50                  55                  60                  


Ser Gly Phe Val Leu Phe Tyr Thr Thr Arg Pro Arg Asp Ser Arg Arg 
65                  70                  75                  80  


Gly Arg Pro Gly Leu Gly Arg Gly Ser Gly Tyr Arg Val His His Asp 
                85                  90                  95      


Val Val Ala Gly Asp Val His Phe Glu His Pro Ala Pro Ala Leu Ala 
            100                 105                 110         


Pro Asn Gly Ser Pro Lys Asp Ser Pro Ala His Glu Val Thr Gly Ser 
        115                 120                 125             


Gly Gly Ala Tyr Met Cys Phe Asp Val Leu Trp Pro Arg Val Gln Arg 
    130                 135                 140                 


Ser Trp Pro Thr Phe Arg Ala Val Leu Leu His Arg Tyr Val Val Ala 
145                 150                 155                 160 


Gly Val Ile Trp Ala Asp Met Leu Ser Ile Ala Val Thr Tyr Phe Ile 
                165                 170                 175     


Thr Leu Cys Leu Phe Pro Asp Leu Glu Ser Glu Ile Cys His Cys Ile 
            180                 185                 190         


Leu Gly Glu Trp Leu Pro Ile Leu Ile Met Ala Val Phe Asn Leu Ser 
        195                 200                 205             


Asp Phe Val Gly Lys Ile Leu Ala Ala Leu Pro Val Asp Trp Arg Gly 
    210                 215                 220                 


Thr His Leu Leu Ala Cys Ser Cys Leu Arg Val Val Phe Ile Pro Leu 
225                 230                 235                 240 


Phe Thr Leu Cys Val Tyr Pro Ser Gly Met Pro Ala Leu Arg His Pro 
                245                 250                 255     


Ala Trp Pro Cys Ile Phe Ser Leu Leu Met Gly Ile Ser Asn Gly Ser 
            260                 265                 270         


Phe Gly Ser Val Pro Met Ile Leu Ala Ala Gly Lys Val Ser Pro Lys 
        275                 280                 285             


Gln Arg Glu Pro Ala Gly Asn Thr Met Thr Val Ser Tyr Val Ser Gly 
    290                 295                 300                 


Leu Thr Leu Gly Ser Ala Val Ala Tyr Cys Thr Tyr Ser Leu Thr Arg 
305                 310                 315                 320 


Asp Ala His Gly Ser Cys Leu His Ala Ser Thr Ala Asn Gly Ser Ile 
                325                 330                 335     


Leu Thr Gly Leu 
            340 

<210>  344
<211>  2072
<212>  DNA
<213>  Homo sapiens

<400>  344
ggcaggaaag aagagtcaca tcacgtaggt gatgggccta gagatatttc acaatgcctt     60

ctgtaattag aacccagaaa aaagagttat atcatttggg ttaaaggtct tgtgatatgt    120

cacaatccca actaagggca ggacccaggc agaaaaggag agtcacttcc tttgatgatt    180

ggtccagaga tacattacaa tttcccctga ggacagctct catgcagaag aggaactgaa    240

tatactgcat ggctcaggta tctgcagatt tatggctaaa agaccaggac cccctggaag    300

ccgagaaatg ggactgttga cattcagaga catagctata gaattctctc tggaggaatg    360

gcaatgcctg gattgtgctc agcggaattt atatagagat gtgatgttag agaactacag    420

aaacctggtc tccctgggta ttgctgtctc taagccagac ttgatcacct gtctggagca    480

aaataaagag tcccagaata taaagagaaa tgagatggta gccaaacacc cagttacgcg    540

ttcccatttc acccaagacc ttcagccaga gcagggcatc aaagattcac tccaaaaagt    600

aataccaaga acatatggaa aatgtggaca tgagaaatta caatttaaaa aatgctgtaa    660

aagtgtgggt gaatatgagg tgcacaaggg aggttatagt gaagttaacc aatgtttgtc    720

aactacccaa aacaaaatat ttcagactca taaatatgtc aaagtctttg gtaaattttc    780

aaattccaat agagataaaa caagatatac tggaaataaa catttcaaat gtaacaaata    840

tggcaaatca ttttgcatgc tttcacacct aaatcaacat caggtaattc atactaggga    900

gaagtcctac aaatgcaaag aatgtggcaa atcctttaac tgctcctcaa accatactac    960

acataaaata attcatactg gagagaaacc atatagatgt gaggaatgtg gcaaagcctt   1020

tagctggtct gcaaacctta ctagacataa gagaactcat actggagaga aaccctacac   1080

gtgtgaagaa tgtggccaag cctttaggcg ctcctcagca cttactaacc acaagagaat   1140

tcatactgga gagagaccct acaaatgtga agaatgtggc aaagccttta gcgtatcctc   1200

aaccctcact gaccacaaga gaattcatac tggagagaaa ccctgcaggt gtgaggaatg   1260

tggcaaagcc tttagctggt cctcaaacct tactagacat aagagaattc atactagaga   1320

gaaaccctat gcctgtgaag aatgtggcca agcctttagc ttatcctcga accttatgag   1380

acataggaga attcatactg gagagaaacc ctacacatgt gaagaatgtg gccaagactt   1440

taggcgctcc tcagcactta ctatccacaa gagaattcat actggagaga gaccctacaa   1500

atgtgaagag tgtggcaaag tctttagctt atcctcaacc ctcactgacc acaagagaat   1560

tcatactgga gagagaccct acaaatgtga agaatgtggc aaagccttta gcttatcctc   1620

aaccctcact gaccacaaga gaattcatac tggagagaga ccctacacat gtgaagaatg   1680

tggcaaagcc tttaattgct cctcaaccct tatgcaacat aagagaattc atactggaga   1740

gaaaccctac aaatgtgaag aatgtgagca agcttttaag tggcattcaa gtcttgctaa   1800

acataagata attcacactg gagagaaacc ctacaaatgt gaataatatg gcaaagtcca   1860

ccctcaggcc ttataataca taaaataatt tacactggaa aaaaacacta caaatgtaga   1920

gaatgtggcc aagcctttaa ccagttccaa accttaattg aatgtaagag aattcatatt   1980

ggacagaaat tttataaatg taaaaaaatg taacaaagcc tttaaccaac cctcaaacct   2040

taataaacct aagagaattt attttaaaaa aa                                 2072


<210>  345
<211>  524
<212>  PRT
<213>  Homo sapiens

<400>  345


Met Ala Lys Arg Pro Gly Pro Pro Gly Ser Arg Glu Met Gly Leu Leu 
1               5                   10                  15      


Thr Phe Arg Asp Ile Ala Ile Glu Phe Ser Leu Glu Glu Trp Gln Cys 
            20                  25                  30          


Leu Asp Cys Ala Gln Arg Asn Leu Tyr Arg Asp Val Met Leu Glu Asn 
        35                  40                  45              


Tyr Arg Asn Leu Val Ser Leu Gly Ile Ala Val Ser Lys Pro Asp Leu 
    50                  55                  60                  


Ile Thr Cys Leu Glu Gln Asn Lys Glu Ser Gln Asn Ile Lys Arg Asn 
65                  70                  75                  80  


Glu Met Val Ala Lys His Pro Val Thr Arg Ser His Phe Thr Gln Asp 
                85                  90                  95      


Leu Gln Pro Glu Gln Gly Ile Lys Asp Ser Leu Gln Lys Val Ile Pro 
            100                 105                 110         


Arg Thr Tyr Gly Lys Cys Gly His Glu Lys Leu Gln Phe Lys Lys Cys 
        115                 120                 125             


Cys Lys Ser Val Gly Glu Tyr Glu Val His Lys Gly Gly Tyr Ser Glu 
    130                 135                 140                 


Val Asn Gln Cys Leu Ser Thr Thr Gln Asn Lys Ile Phe Gln Thr His 
145                 150                 155                 160 


Lys Tyr Val Lys Val Phe Gly Lys Phe Ser Asn Ser Asn Arg Asp Lys 
                165                 170                 175     


Thr Arg Tyr Thr Gly Asn Lys His Phe Lys Cys Asn Lys Tyr Gly Lys 
            180                 185                 190         


Ser Phe Cys Met Leu Ser His Leu Asn Gln His Gln Val Ile His Thr 
        195                 200                 205             


Arg Glu Lys Ser Tyr Lys Cys Lys Glu Cys Gly Lys Ser Phe Asn Cys 
    210                 215                 220                 


Ser Ser Asn His Thr Thr His Lys Ile Ile His Thr Gly Glu Lys Pro 
225                 230                 235                 240 


Tyr Arg Cys Glu Glu Cys Gly Lys Ala Phe Ser Trp Ser Ala Asn Leu 
                245                 250                 255     


Thr Arg His Lys Arg Thr His Thr Gly Glu Lys Pro Tyr Thr Cys Glu 
            260                 265                 270         


Glu Cys Gly Gln Ala Phe Arg Arg Ser Ser Ala Leu Thr Asn His Lys 
        275                 280                 285             


Arg Ile His Thr Gly Glu Arg Pro Tyr Lys Cys Glu Glu Cys Gly Lys 
    290                 295                 300                 


Ala Phe Ser Val Ser Ser Thr Leu Thr Asp His Lys Arg Ile His Thr 
305                 310                 315                 320 


Gly Glu Lys Pro Cys Arg Cys Glu Glu Cys Gly Lys Ala Phe Ser Trp 
                325                 330                 335     


Ser Ser Asn Leu Thr Arg His Lys Arg Ile His Thr Arg Glu Lys Pro 
            340                 345                 350         


Tyr Ala Cys Glu Glu Cys Gly Gln Ala Phe Ser Leu Ser Ser Asn Leu 
        355                 360                 365             


Met Arg His Arg Arg Ile His Thr Gly Glu Lys Pro Tyr Thr Cys Glu 
    370                 375                 380                 


Glu Cys Gly Gln Asp Phe Arg Arg Ser Ser Ala Leu Thr Ile His Lys 
385                 390                 395                 400 


Arg Ile His Thr Gly Glu Arg Pro Tyr Lys Cys Glu Glu Cys Gly Lys 
                405                 410                 415     


Val Phe Ser Leu Ser Ser Thr Leu Thr Asp His Lys Arg Ile His Thr 
            420                 425                 430         


Gly Glu Arg Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Ser Leu 
        435                 440                 445             


Ser Ser Thr Leu Thr Asp His Lys Arg Ile His Thr Gly Glu Arg Pro 
    450                 455                 460                 


Tyr Thr Cys Glu Glu Cys Gly Lys Ala Phe Asn Cys Ser Ser Thr Leu 
465                 470                 475                 480 


Met Gln His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu 
                485                 490                 495     


Glu Cys Glu Gln Ala Phe Lys Trp His Ser Ser Leu Ala Lys His Lys 
            500                 505                 510         


Ile Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu 
        515                 520                 

<210>  346
<211>  978
<212>  DNA
<213>  Homo sapiens

<400>  346
tcaggtacct gatgcgacct gtccgcagcc tcctcctgca ctgctcttag ccctgcagac     60

ggtggccaag cagtggagtg gaaagcgtga cctagtggac aggtgtggcc tgcacggcgt    120

ttgggccgct gttgctgtgt gctggcactg caaggcggga tgctgtaccc caaggagagt    180

ccgtcgcggg agcccaagga gctgggtggc ctctggagct tccctgccga tttggacaac    240

cgacgccagg gctttaagga gaagtggtac ccgcggccac tgcaggagtc aggccccacc    300

ctggacgtgc tggttccctt cagcttcaac gacattggcc aggactggcg cctgcggcat    360

tttgttagct ggatgttgta cgaatgggag gtgaccctgc cggagaaatg gacccaggac    420

ctgcgtgcaa gagtggtgct gaggattggc agtgcccact cctatgatat cgtggtatcc    480

caagggttgt tttgtccaga acacagactg acttcttcaa ctacgcggga ctgcagtggt    540

ctgtgcttct gtacacgaca cccaccacct acatcgatga catcaccatc accaccggtg    600

tggagcatga cagtggtgag ggcttctgct gtgtcctctc attttactcc agaccttttg    660

cctgggcaga gcataaaaca tttattccca aaagtgataa tgagaagata tgaaagctat    720

ggcattgaaa atttaaagtt aaaagactgg aaaagcgtgg gttagtgtac gggacagaaa    780

aaagttatag tggacttaac caatgttaat ctttcaatgt gatgaatgtg gcaaagcttt    840

taactggtgc ttaatcttta ttcaacataa gagaattaat acaggagaga aaccatacaa    900

atgtgaggaa tgtggaaaag cctttaactg gttttcaaac cttattcgaa ataagagaat    960

tcgtactgta gagaaact                                                  978


<210>  347
<211>  201
<212>  PRT
<213>  Homo sapiens

<400>  347


Met Leu Tyr Pro Lys Glu Ser Pro Ser Arg Glu Pro Lys Glu Leu Gly 
1               5                   10                  15      


Gly Leu Trp Ser Phe Pro Ala Asp Leu Asp Asn Arg Arg Gln Gly Phe 
            20                  25                  30          


Lys Glu Lys Trp Tyr Pro Arg Pro Leu Gln Glu Ser Gly Pro Thr Leu 
        35                  40                  45              


Asp Val Leu Val Pro Phe Ser Phe Asn Asp Ile Gly Gln Asp Trp Arg 
    50                  55                  60                  


Leu Arg His Phe Val Ser Trp Met Leu Tyr Glu Trp Glu Val Thr Leu 
65                  70                  75                  80  


Pro Glu Lys Trp Thr Gln Asp Leu Arg Ala Arg Val Val Leu Arg Ile 
                85                  90                  95      


Gly Ser Ala His Ser Tyr Asp Ile Val Val Ser Gln Gly Leu Phe Cys 
            100                 105                 110         


Pro Glu His Arg Leu Thr Ser Ser Thr Thr Arg Asp Cys Ser Gly Leu 
        115                 120                 125             


Cys Phe Cys Thr Arg His Pro Pro Pro Thr Ser Met Thr Ser Pro Ser 
    130                 135                 140                 


Pro Pro Val Trp Ser Met Thr Val Val Arg Ala Ser Ala Val Ser Ser 
145                 150                 155                 160 


His Phe Thr Pro Asp Leu Leu Pro Gly Gln Ser Ile Lys His Leu Phe 
                165                 170                 175     


Pro Lys Val Ile Met Arg Arg Tyr Glu Ser Tyr Gly Ile Glu Asn Leu 
            180                 185                 190         


Lys Leu Lys Asp Trp Lys Ser Val Gly 
        195                 200     

<210>  348
<211>  6426
<212>  DNA
<213>  Homo sapiens

<400>  348
gggagctgcg ctcgcagttt cgccctctct tccgctaatg attgcattat tatgctcccc     60

tctctggggg gtctcgcccc tcttgggtcg ctccggagcc ccggcctccc ctggctgcat    120

ttcttaaaaa tttgggagcc tgggagtgag ttttctccga ggcgtgtgtg agaggcggcg    180

ggggtgtttt cctgcgcgag gggcgggtga agttcattgc ccccactttt cccgcgacct    240

ttttcggacc cgattttgga tcgagttgag gggggcgcgg gcgttttcgg ggggcggggg    300

gcgcggcgga gaatggccgc ggggagggct ccccggagcc tcccagtctc ttgatcaaag    360

cattccgcta ttctgattta ttgcttgctt ggtgagttat ttttttttcc tctaaaggag    420

acctgtgtgt tcagccatta ctttgctcgg cgctgctccc aggcatctcc gaccctcggt    480

gctgtgggga gccccacact tgggctcctc gcctctcgcc ctcgctcccc gtccctcctc    540

ccctctctcc gccccttccc ccttttcttt ctcctctctt tcttcccctc tctcccttct    600

ttcggccgcc gtctcccccg cgccctcctc ggggcggagg gaagccgtga agggggaggg    660

agggctcggt gtcaattttt ttttgtgtgg ctgcggccgt agcctgtggc gggcaagcgg    720

ggagaccccg gcgcagcaga accatggatg gcccgacgcg gggccatgga ctccgcaaaa    780

agcggcggtc gcggtcgcag cgagaccggg agaggcgctc ccggggcggg ctgggggccg    840

gcgcggccgg cggcggcggg gctggccgga cccgggcgct ctcactcgcc tcgtcgtcgg    900

gctccgacaa ggaagacaat gggaagcccc cgtcctccgc cccgtcccgg cccagacccc    960

cgcggaggaa gcggagagag tccacctcgg cagaagagga catcattgat ggatttgcca   1020

tgaccagctt tgtcactttt gaagcgctgg agaaagatgt agcacttaag cctcaggaac   1080

gtgtggagaa acgccagacg cccctgacca agaagaaacg agaagcactt accaatggct   1140

tgtcctttca ttcaaagaag agcagactca gccacccaca ccactacagc tcagatcgag   1200

aaaatgaccg caatctctgc cagcaccttg ggaagagaaa gaaaatgccg aaggcactca   1260

gacagctcaa gccaggacag aacagctgca gggacagtga cagtgaaagt gccagtggag   1320

aatccaaggg cttccaccgg agcagctctc gggaaaggct cagtgatagt tcagctcctt   1380

ccagcttggg aacaggctac ttctgtgaca gtgacagtga ccaggaagag aaggcatcag   1440

atgccagctc tgaaaaactc ttcaacactg ttattgtaaa caaagatccg gagttaggtg   1500

ttggcacgct accagaacat gacagccagg atgcagggcc gattgtcccc aagatatcgg   1560

gtctagagag aagccaggag aagagccagg actgttgcaa agagccaatc tttgagcctg   1620

tggtgcttaa agacccctgc cctcaggtcg cacagccaat accccagccg cagacggagc   1680

cccaactccg agctccttct ccggaccctg acttggtgca gcgcacagag gccccacctc   1740

aacccccacc tctgagtaca cagccaccac agggccctcc tgaggcccag ctccagcctg   1800

ccccgcagcc tcaggtgcag aggccaccca ggccacagtc ccccacccag ctgctccatc   1860

agaacctccc acctgtgcag gcccacccct ctgctcagag cctctcccag ccattgtcag   1920

cctacaacag cagtagctta agcctcaaca gtttaagcag cagcagaagc agcactccag   1980

cgaagactca gcccgcccca cctcacatct cccaccaccc ctctgcctcc ccgttccccc   2040

tctccctgcc caaccacagc cccctgcaca gcttcacacc caccctccag ccccccgcac   2100

actcacatca ccccaatatg tttgcccctc ccactgctct gcctcctcca ccaccactga   2160

catcaggaag tctgcaggtg gccggacacc cggccgggag cacttactca gagcaagaca   2220

tcttgcgaca ggaactgaac actcgttttt tggcctctca gagtgctgac cgcggggctt   2280

ccctgggccc tccgccctac ctgcggaccg agttccatca gcaccagcac cagcaccagc   2340

acacccacca gcacacgcac cagcacacct tcacgccgtt cccccacgcc atcccaccca   2400

ccgccatcat gccgacgcca gcacctccca tgtttgacaa ataccctaca aaagttgacc   2460

cattctaccg gcacagtctc ttccattcct atcctcctgc agtgtcgggc atccccccta   2520

tgatcccacc cactggccct tttggttcac tacaaggagc atttcagccg aagacatcca   2580

accctatcga tgtcgctgct cggcctggga cagtcccaca cactttactc caaaaggacc   2640

cgaggttgac agatcctttc agacctatgt taaggaaacc agggaagtgg tgtgctatgc   2700

atgttcacat cgcctggcag atttaccacc accaacagaa agtcaagaaa cagatgcagt   2760

cagacccaca taagctggac tttggactga aacctgagtt cctgagccgc cctccaggcc   2820

ccagtctttt tggagccatc caccaccccc atgacctggc acggccttca actttgttct   2880

ctgccgctgg tgctgcacac ccaactggga ccccttttgg gccacctcct catcacagca   2940

acttcctcaa ccctgctgcc cacctagagc cttttaatcg gccgtctaca ttcacaggcc   3000

tagcagcagt tggtggcaat gccttcgggg gacttggaaa tccttccgtt acacccaact   3060

caatgttcgg ccacaaggat ggccccagtg tgcagaactt tagcaaccct cacgaaccct   3120

ggaaccggct gcaccgaacg cctccgtcgt tcccgacccc tccgccctgg ctgaagccag   3180

gggagctgga gcgcagcgcg tccgctgcag ctcatgacag agatagagat gtagataaac   3240

gagactcatc tgttagtaaa gatgacaaag aaagggaaag cgtcgagaag agacactcca   3300

gccacccttc accagcacct gtcctcccgg tgaatgccct gggacatacc cgcagctcca   3360

ctgaacagat ccgggctcat ctgaacactg aggctcggga gaaggacaaa cccaaagaga   3420

gggagagaga ccactcggaa tcccgcaagg acctggccgc cgacgagcac aaggcgaaag   3480

agggccacct gcccgagaag gacgggcacg gccacgaggg gcgcgccgcg ggcgaagagg   3540

ccaagcagct ggcccgggtg ccgtctccct acgtgcggac cccggtggtg gagagtgcca   3600

ggcccaacag cacctcgagc cgggaggccg agccgcgcaa gggtgagccg gcctacgaga   3660

accccaagaa gagctccgag gtcaaggtga aggaggagcg gaaggaagac catgacctgc   3720

ctccagaggc cccgcagacc caccgggcct cggagccgcc gcctcccaac tcctcgtcca   3780

gcgtgcaccc ggggcccctg gcctcgatgc ccatgacggt gggggtgacg ggcattcacc   3840

ccatgaacag catcagcagc ctggacagga ctcgcatgat gacccccttc atgggcatca   3900

gccccctccc gggcggagag cgcttcccgt acccttcttt ccactgggac cccatccggg   3960

accccttgag ggatccttac cgagaacttg acattcaccg gagagacccg ctgggcaggg   4020

acttcctgct aaggaacgac ccgctccacc ggctctcgac tccccggctg tacgaagccg   4080

accgctcctt cagggaccgg gagcctcacg actacagcca ccaccaccac caccaccacc   4140

acccgctgtc tgtggaccct cggcgggagc acgagcgggg aggccacctg gacgagcggg   4200

agcgcttgca catgctcaga gaagactacg agcacacgcg gctccactcc gtgcaccccg   4260

cctccctcga cggacacctc ccccacccca gcctcatcac cccgggactc cccagcatgc   4320

actatccccg catcagcccc accgcgggca accagaacgg actcctcaac aagacccctc   4380

cgacagcagc gctgagcgca cctcccccgc tcatctccac gctggggggc cgcccggtct   4440

ctcccagaag gacgactcct ctgtccgcag agataaggga gaggccccct tcccacacgc   4500

tgaaggatat cgaggcccga taagccgaga acaggagcaa gaacgaggaa gaagaaaccc   4560

taggcagaca ccaggccagg cttgagagac agaactcctg catggctcac acagactggg   4620

ggggaaagcc ccaccccttc cccttgtaaa aaatgtatag actcagtgca cattttgaaa   4680

tgttttgtat attatatgtt gagatttttc agatctttta gcccagtcat atgttctcac   4740

gtctcctact ttttgtttct cgtataaaac tttttgattt gaaccaaaac agtgaagatg   4800

acaacacaca ccaattggat gataattgta gcgggggcgg tgggggggag aagtccacgc   4860

catccatcat gcaaaattct ttcagatgag gtgggaaggc cgtgtacata gttatgtaaa   4920

aagagattgc ttcatgagct aatggttcat atatgcaaaa gggtaagatg aaagctttac   4980

tttgtacaaa tgtaaataga taaagtaaca taatacatta atacttctta aaatgtgcta   5040

tttgcaaact tacttaatat cagtgaacac agtcggctaa agctgtgttc ccatatattg   5100

ttatagacag ctaaaccctt caactatgca atgaatgttc gggcttttca caaaagcccg   5160

cctaactcaa aggagccttt tcaaatccat ttacagcata cttaaggtca tattttccct   5220

gaacaagcgc ttacgtgata tgactctgtt ttccttgctt gttttttttc aaacggagaa   5280

acatcctgtt ttgcaaattg gaccccaggc tggaacttag catctgaagt tgccgcttgt   5340

gggctctggg ggaaagtgta gccccggaga ggtaactgag gacatgagca accagtgcca   5400

gggagggtgg gatttgccag atgccaaaat caggggacgg gtggtggtgt ctgtcagaca   5460

cacacaggtc gccagtgact tcacacacac ctcatgtgag aaccatgcct tttttagtgt   5520

gtcctatttc atacctgtac acacttcctc gttttgtaat gagatttact tacacccaaa   5580

cagatcctga aagaaagctt caagttttct cagatgatgg atatgttttc actgtattca   5640

ataactgacg gatgtaaggt gcacgtttcc tgatgtgacg cactgtattc cagctggtga   5700

tcaagtctgg gaacagccgt aacaggtcaa ccttgtggag ccatcgcgag ttagagggtg   5760

aaagatggca gaaaaaaaag tcttgtgtgt gagtgtgttt tttgagtttg catcaatctt   5820

aatgtctctt cataatactt ttataataca ttaagcctct tgtctacata tttggagaga   5880

atatgacttt actagcagag aaatacaata tatcttgtct actggactgt aaaatatatg   5940

tatgaaataa aattagttcc atttggtctt ctagtatatt aaagtgctat ctgacgttgt   6000

tatcctgttt ttgcaaaaaa aaaaaaaaaa aaaagttaac tacagaccat tgtttctaat   6060

aagcagagag atctatttta gtagtaaact gaaggtttag ttgtgagctt cagattttgt   6120

gaactccaga tgttgtgcgg tgtttttttt tttttttaag acaacaacta aaaaaaatgc   6180

aaggaatatg tacactggaa ctgtagtggt agctttcagt attgtaaaga gattgttcta   6240

tacggacctt tttgctgttt atcctgtatg taataaagtc ctttctagat cctatgtgaa   6300

aagaaaagtg aagcaactga atcttcagca tgttctcatc ggcggagcct tcttgtgtaa   6360

tgtaaactgt gccatgttat taaaaaatgt gaactaagct tccagctgct tgtttgtgtg   6420

aggtga                                                              6426


<210>  349
<211>  1259
<212>  PRT
<213>  Homo sapiens

<400>  349


Met Asp Gly Pro Thr Arg Gly His Gly Leu Arg Lys Lys Arg Arg Ser 
1               5                   10                  15      


Arg Ser Gln Arg Asp Arg Glu Arg Arg Ser Arg Gly Gly Leu Gly Ala 
            20                  25                  30          


Gly Ala Ala Gly Gly Gly Gly Ala Gly Arg Thr Arg Ala Leu Ser Leu 
        35                  40                  45              


Ala Ser Ser Ser Gly Ser Asp Lys Glu Asp Asn Gly Lys Pro Pro Ser 
    50                  55                  60                  


Ser Ala Pro Ser Arg Pro Arg Pro Pro Arg Arg Lys Arg Arg Glu Ser 
65                  70                  75                  80  


Thr Ser Ala Glu Glu Asp Ile Ile Asp Gly Phe Ala Met Thr Ser Phe 
                85                  90                  95      


Val Thr Phe Glu Ala Leu Glu Lys Asp Val Ala Leu Lys Pro Gln Glu 
            100                 105                 110         


Arg Val Glu Lys Arg Gln Thr Pro Leu Thr Lys Lys Lys Arg Glu Ala 
        115                 120                 125             


Leu Thr Asn Gly Leu Ser Phe His Ser Lys Lys Ser Arg Leu Ser His 
    130                 135                 140                 


Pro His His Tyr Ser Ser Asp Arg Glu Asn Asp Arg Asn Leu Cys Gln 
145                 150                 155                 160 


His Leu Gly Lys Arg Lys Lys Met Pro Lys Ala Leu Arg Gln Leu Lys 
                165                 170                 175     


Pro Gly Gln Asn Ser Cys Arg Asp Ser Asp Ser Glu Ser Ala Ser Gly 
            180                 185                 190         


Glu Ser Lys Gly Phe His Arg Ser Ser Ser Arg Glu Arg Leu Ser Asp 
        195                 200                 205             


Ser Ser Ala Pro Ser Ser Leu Gly Thr Gly Tyr Phe Cys Asp Ser Asp 
    210                 215                 220                 


Ser Asp Gln Glu Glu Lys Ala Ser Asp Ala Ser Ser Glu Lys Leu Phe 
225                 230                 235                 240 


Asn Thr Val Ile Val Asn Lys Asp Pro Glu Leu Gly Val Gly Thr Leu 
                245                 250                 255     


Pro Glu His Asp Ser Gln Asp Ala Gly Pro Ile Val Pro Lys Ile Ser 
            260                 265                 270         


Gly Leu Glu Arg Ser Gln Glu Lys Ser Gln Asp Cys Cys Lys Glu Pro 
        275                 280                 285             


Ile Phe Glu Pro Val Val Leu Lys Asp Pro Cys Pro Gln Val Ala Gln 
    290                 295                 300                 


Pro Ile Pro Gln Pro Gln Thr Glu Pro Gln Leu Arg Ala Pro Ser Pro 
305                 310                 315                 320 


Asp Pro Asp Leu Val Gln Arg Thr Glu Ala Pro Pro Gln Pro Pro Pro 
                325                 330                 335     


Leu Ser Thr Gln Pro Pro Gln Gly Pro Pro Glu Ala Gln Leu Gln Pro 
            340                 345                 350         


Ala Pro Gln Pro Gln Val Gln Arg Pro Pro Arg Pro Gln Ser Pro Thr 
        355                 360                 365             


Gln Leu Leu His Gln Asn Leu Pro Pro Val Gln Ala His Pro Ser Ala 
    370                 375                 380                 


Gln Ser Leu Ser Gln Pro Leu Ser Ala Tyr Asn Ser Ser Ser Leu Ser 
385                 390                 395                 400 


Leu Asn Ser Leu Ser Ser Ser Arg Ser Ser Thr Pro Ala Lys Thr Gln 
                405                 410                 415     


Pro Ala Pro Pro His Ile Ser His His Pro Ser Ala Ser Pro Phe Pro 
            420                 425                 430         


Leu Ser Leu Pro Asn His Ser Pro Leu His Ser Phe Thr Pro Thr Leu 
        435                 440                 445             


Gln Pro Pro Ala His Ser His His Pro Asn Met Phe Ala Pro Pro Thr 
    450                 455                 460                 


Ala Leu Pro Pro Pro Pro Pro Leu Thr Ser Gly Ser Leu Gln Val Ala 
465                 470                 475                 480 


Gly His Pro Ala Gly Ser Thr Tyr Ser Glu Gln Asp Ile Leu Arg Gln 
                485                 490                 495     


Glu Leu Asn Thr Arg Phe Leu Ala Ser Gln Ser Ala Asp Arg Gly Ala 
            500                 505                 510         


Ser Leu Gly Pro Pro Pro Tyr Leu Arg Thr Glu Phe His Gln His Gln 
        515                 520                 525             


His Gln His Gln His Thr His Gln His Thr His Gln His Thr Phe Thr 
    530                 535                 540                 


Pro Phe Pro His Ala Ile Pro Pro Thr Ala Ile Met Pro Thr Pro Ala 
545                 550                 555                 560 


Pro Pro Met Phe Asp Lys Tyr Pro Thr Lys Val Asp Pro Phe Tyr Arg 
                565                 570                 575     


His Ser Leu Phe His Ser Tyr Pro Pro Ala Val Ser Gly Ile Pro Pro 
            580                 585                 590         


Met Ile Pro Pro Thr Gly Pro Phe Gly Ser Leu Gln Gly Ala Phe Gln 
        595                 600                 605             


Pro Lys Thr Ser Asn Pro Ile Asp Val Ala Ala Arg Pro Gly Thr Val 
    610                 615                 620                 


Pro His Thr Leu Leu Gln Lys Asp Pro Arg Leu Thr Asp Pro Phe Arg 
625                 630                 635                 640 


Pro Met Leu Arg Lys Pro Gly Lys Trp Cys Ala Met His Val His Ile 
                645                 650                 655     


Ala Trp Gln Ile Tyr His His Gln Gln Lys Val Lys Lys Gln Met Gln 
            660                 665                 670         


Ser Asp Pro His Lys Leu Asp Phe Gly Leu Lys Pro Glu Phe Leu Ser 
        675                 680                 685             


Arg Pro Pro Gly Pro Ser Leu Phe Gly Ala Ile His His Pro His Asp 
    690                 695                 700                 


Leu Ala Arg Pro Ser Thr Leu Phe Ser Ala Ala Gly Ala Ala His Pro 
705                 710                 715                 720 


Thr Gly Thr Pro Phe Gly Pro Pro Pro His His Ser Asn Phe Leu Asn 
                725                 730                 735     


Pro Ala Ala His Leu Glu Pro Phe Asn Arg Pro Ser Thr Phe Thr Gly 
            740                 745                 750         


Leu Ala Ala Val Gly Gly Asn Ala Phe Gly Gly Leu Gly Asn Pro Ser 
        755                 760                 765             


Val Thr Pro Asn Ser Met Phe Gly His Lys Asp Gly Pro Ser Val Gln 
    770                 775                 780                 


Asn Phe Ser Asn Pro His Glu Pro Trp Asn Arg Leu His Arg Thr Pro 
785                 790                 795                 800 


Pro Ser Phe Pro Thr Pro Pro Pro Trp Leu Lys Pro Gly Glu Leu Glu 
                805                 810                 815     


Arg Ser Ala Ser Ala Ala Ala His Asp Arg Asp Arg Asp Val Asp Lys 
            820                 825                 830         


Arg Asp Ser Ser Val Ser Lys Asp Asp Lys Glu Arg Glu Ser Val Glu 
        835                 840                 845             


Lys Arg His Ser Ser His Pro Ser Pro Ala Pro Val Leu Pro Val Asn 
    850                 855                 860                 


Ala Leu Gly His Thr Arg Ser Ser Thr Glu Gln Ile Arg Ala His Leu 
865                 870                 875                 880 


Asn Thr Glu Ala Arg Glu Lys Asp Lys Pro Lys Glu Arg Glu Arg Asp 
                885                 890                 895     


His Ser Glu Ser Arg Lys Asp Leu Ala Ala Asp Glu His Lys Ala Lys 
            900                 905                 910         


Glu Gly His Leu Pro Glu Lys Asp Gly His Gly His Glu Gly Arg Ala 
        915                 920                 925             


Ala Gly Glu Glu Ala Lys Gln Leu Ala Arg Val Pro Ser Pro Tyr Val 
    930                 935                 940                 


Arg Thr Pro Val Val Glu Ser Ala Arg Pro Asn Ser Thr Ser Ser Arg 
945                 950                 955                 960 


Glu Ala Glu Pro Arg Lys Gly Glu Pro Ala Tyr Glu Asn Pro Lys Lys 
                965                 970                 975     


Ser Ser Glu Val Lys Val Lys Glu Glu Arg Lys Glu Asp His Asp Leu 
            980                 985                 990         


Pro Pro Glu Ala Pro Gln Thr His  Arg Ala Ser Glu Pro  Pro Pro Pro 
        995                 1000                 1005             


Asn Ser  Ser Ser Ser Val His  Pro Gly Pro Leu Ala  Ser Met Pro 
    1010                 1015                 1020             


Met Thr  Val Gly Val Thr Gly  Ile His Pro Met Asn  Ser Ile Ser 
    1025                 1030                 1035             


Ser Leu  Asp Arg Thr Arg Met  Met Thr Pro Phe Met  Gly Ile Ser 
    1040                 1045                 1050             


Pro Leu  Pro Gly Gly Glu Arg  Phe Pro Tyr Pro Ser  Phe His Trp 
    1055                 1060                 1065             


Asp Pro  Ile Arg Asp Pro Leu  Arg Asp Pro Tyr Arg  Glu Leu Asp 
    1070                 1075                 1080             


Ile His  Arg Arg Asp Pro Leu  Gly Arg Asp Phe Leu  Leu Arg Asn 
    1085                 1090                 1095             


Asp Pro  Leu His Arg Leu Ser  Thr Pro Arg Leu Tyr  Glu Ala Asp 
    1100                 1105                 1110             


Arg Ser  Phe Arg Asp Arg Glu  Pro His Asp Tyr Ser  His His His 
    1115                 1120                 1125             


His His  His His His Pro Leu  Ser Val Asp Pro Arg  Arg Glu His 
    1130                 1135                 1140             


Glu Arg  Gly Gly His Leu Asp  Glu Arg Glu Arg Leu  His Met Leu 
    1145                 1150                 1155             


Arg Glu  Asp Tyr Glu His Thr  Arg Leu His Ser Val  His Pro Ala 
    1160                 1165                 1170             


Ser Leu  Asp Gly His Leu Pro  His Pro Ser Leu Ile  Thr Pro Gly 
    1175                 1180                 1185             


Leu Pro  Ser Met His Tyr Pro  Arg Ile Ser Pro Thr  Ala Gly Asn 
    1190                 1195                 1200             


Gln Asn  Gly Leu Leu Asn Lys  Thr Pro Pro Thr Ala  Ala Leu Ser 
    1205                 1210                 1215             


Ala Pro  Pro Pro Leu Ile Ser  Thr Leu Gly Gly Arg  Pro Val Ser 
    1220                 1225                 1230             


Pro Arg  Arg Thr Thr Pro Leu  Ser Ala Glu Ile Arg  Glu Arg Pro 
    1235                 1240                 1245             


Pro Ser  His Thr Leu Lys Asp  Ile Glu Ala Arg 
    1250                 1255                 

<210>  350
<211>  3572
<212>  DNA
<213>  Homo sapiens

<400>  350
gaataattct gctacaaggc tgatttcaag gacatgaatt gttgacctca tcccaacatc     60

agaacctcag atgttctaat ttttgcacca ttccaggcaa gttgatctta taaggaaata    120

aaattgaacc ttaggggtct gatggaaatt cactgtgaca ttcaaatcaa gaaaacttgc    180

taatgcccac agagcctttt ccccatgggc cctgatggta gcctccagaa ggtgcagcct    240

caggtggtgc cctttcttct gtggcaagaa taaactttgg gtcttggatt gcaataccac    300

ctgtggagaa aatggtatgc gagggaaagc gatcagcctc ttgcccttgt ttcttcctct    360

tgaccgccaa gttctactgg atcctcacaa tgatgcaaag aactcacagc caggagtatg    420

cccattccat acgggtggat ggggacatta ttttgggggg tctcttccct gtccacgcaa    480

agggagagag aggggtgcct tgtggggagc tgaagaagga aaaggggatt cacagactgg    540

aggccatgct ttatgcaatt gaccagatta acaaggaccc tgatctcctt tccaacatca    600

ctctgggtgt ccgcatcctc gacacgtgct ctagggacac ctatgctttg gagcagtctc    660

taacattcgt gcaggcatta atagagaaag atgcttcgga tgtgaagtgt gctaatggag    720

atccacccat tttcaccaag cccgacaaga tttctggcgt cataggtgct gcagcaagct    780

ccgtgtccat catggttgct aacattttaa gactttttaa gatacctcaa atcagctatg    840

catccacagc cccagagcta agtgataaca ccaggtatga ctttttctct cgagtggttc    900

cgcctgactc ctaccaagcc caagccatgg tggacatcgt gacagcactg ggatggaatt    960

atgtttcgac actggcttct gaggggaact atggtgagag cggtgtggag gccttcaccc   1020

agatctcgag ggagattggt ggtgtttgca ttgctcagtc acagaaaatc ccacgtgaac   1080

caagacctgg agaatttgaa aaaattatca aacgcctgct agaaacacct aatgctcgag   1140

cagtgattat gtttgccaat gaggatgaca tcaggaggat attggaagca gcaaaaaaac   1200

taaaccaaag tgggcatttt ctctggattg gctcagatag ttggggatcc aaaatagcac   1260

ctgtctatca gcaagaggag attgcagaag gggctgtgac aattttgccc aaacgagcat   1320

caattgatgg atttgatcga tactttagaa gccgaactct tgccaataat cgaagaaatg   1380

tgtggtttgc agaattctgg gaggagaatt ttggctgcaa gttaggatca catgggaaaa   1440

ggaacagtca tataaagaaa tgcacagggc tggagcgaat tgctcgggat tcatcttatg   1500

aacaggaagg aaaggtccaa tttgtaattg atgctgtata ttccatggct tacgccctgc   1560

acaatatgca caaagatctc tgccctggat acattggcct ttgtccacga atgagtacca   1620

ttgatgggaa agagctactt ggttatattc gggctgtaaa ttttaatggc agtgctggca   1680

ctcctgtcac ttttaatgaa aacggagatg ctcctggacg ttatgatatc ttccagtatc   1740

aaataaccaa caaaagcaca gagtacaaag tcatcggcca ctggaccaat cagcttcatc   1800

taaaagtgga agacatgcag tgggctcata gagaacatac tcacccggcg tctgtctgca   1860

gcctgccgtg taagccaggg gagaggaaga aaacggtgaa aggggtccct tgctgctggc   1920

actgtgaacg ctgtgaaggt tacaactacc aggtggatga gctgtcctgt gaactttgcc   1980

ctctggatca gagacccaac atgaaccgca caggctgcca gcttatcccc atcatcaaat   2040

tggagtggca ttctccctgg gctgtggtgc ctgtgtttgt tgcaatattg ggaatcatcg   2100

ccaccacctt tgtgatcgtg acctttgtcc gctataatga cacacctatc gtgagggctt   2160

caggacgcga acttagttac gtgctcctaa cggggatttt tctctgttat tcaatcacgt   2220

ttttaatgat tgcagcacca gatacaatca tatgctcctt ccgacgggtc ttcctaggac   2280

ttggcatgtg tttcagctat gcagcccttc tgaccaaaac aaaccgtatc caccgaatat   2340

ttgagcaggg gaagaaatct gtcacagcgc ccaagttcat tagtccagca tctcagctgg   2400

tgatcacctt cagcctcatc tccgtccagc tccttggagt gtttgtctgg tttgttgtgg   2460

atccccccca catcatcatt gactatggag agcagcggac actagatcca gagaaggcca   2520

ggggagtgct caagtgtgac atttctgatc tctcactcat ttgttcactt ggatacagta   2580

tcctcttgat ggtcacttgt actgtttatg ccattaaaac gagaggtgtc ccagagactt   2640

tcaatgaagc caaacctatt ggatttacca tgtataccac ctgcatcatt tggttagctt   2700

tcatccccat cttttttggt acagcccagt cagcagaaaa gatgtacatc cagacaacaa   2760

cacttactgt ctccatgagt ttaagtgctt cagtatctct gggcatgctc tatatgccca   2820

aggtttatat tataattttt catccagaac agaatgttca aaaacgcaag aggagcttca   2880

aggctgtggt gacagctgcc accatgcaaa gcaaactgat ccaaaaagga aatgacagac   2940

caaatggcga ggtgaaaagt gaactctgtg agagtcttga aaccaacact tcctctacca   3000

agacaacata tatcagttac agcaatcatt caatctgaaa cagggaaatg gcacaatctg   3060

aagagatgtg gtatatgatc ttaaatgatg aacatgagac cgcaaaaatt cactcctgga   3120

gatctccgta gactacaatc aatcaaatca atagtcagtc ttgtaaggaa caaaaattag   3180

ccatgagcca aaagtatcaa taaacgggga gtgaagaaac ccgttttata caataaaacc   3240

aatgagtgtc aagctaaagt attgcttatt catgagcagt taaaacaaat cacaaaagga   3300

aaactaatgt tagctcgtga aaaaaaatgc tgttgaaata aataatgtct gatgttattc   3360

ttgtattttt ctgtgattgt gagaactccc gttcctgtcc cacattgttt aacttgtata   3420

agacaatgag tctgtttctt gtaatggctg accagattga agccctgggt tgtgctaaaa   3480

ataaatgcaa tgattgatgc atgcaatttt ttatacaaat aatttatttc taataataaa   3540

ggaatgtttt gcaaatgtta aaaaaaaaaa aa                                 3572


<210>  351
<211>  908
<212>  PRT
<213>  Homo sapiens

<400>  351


Met Val Cys Glu Gly Lys Arg Ser Ala Ser Cys Pro Cys Phe Phe Leu 
1               5                   10                  15      


Leu Thr Ala Lys Phe Tyr Trp Ile Leu Thr Met Met Gln Arg Thr His 
            20                  25                  30          


Ser Gln Glu Tyr Ala His Ser Ile Arg Val Asp Gly Asp Ile Ile Leu 
        35                  40                  45              


Gly Gly Leu Phe Pro Val His Ala Lys Gly Glu Arg Gly Val Pro Cys 
    50                  55                  60                  


Gly Glu Leu Lys Lys Glu Lys Gly Ile His Arg Leu Glu Ala Met Leu 
65                  70                  75                  80  


Tyr Ala Ile Asp Gln Ile Asn Lys Asp Pro Asp Leu Leu Ser Asn Ile 
                85                  90                  95      


Thr Leu Gly Val Arg Ile Leu Asp Thr Cys Ser Arg Asp Thr Tyr Ala 
            100                 105                 110         


Leu Glu Gln Ser Leu Thr Phe Val Gln Ala Leu Ile Glu Lys Asp Ala 
        115                 120                 125             


Ser Asp Val Lys Cys Ala Asn Gly Asp Pro Pro Ile Phe Thr Lys Pro 
    130                 135                 140                 


Asp Lys Ile Ser Gly Val Ile Gly Ala Ala Ala Ser Ser Val Ser Ile 
145                 150                 155                 160 


Met Val Ala Asn Ile Leu Arg Leu Phe Lys Ile Pro Gln Ile Ser Tyr 
                165                 170                 175     


Ala Ser Thr Ala Pro Glu Leu Ser Asp Asn Thr Arg Tyr Asp Phe Phe 
            180                 185                 190         


Ser Arg Val Val Pro Pro Asp Ser Tyr Gln Ala Gln Ala Met Val Asp 
        195                 200                 205             


Ile Val Thr Ala Leu Gly Trp Asn Tyr Val Ser Thr Leu Ala Ser Glu 
    210                 215                 220                 


Gly Asn Tyr Gly Glu Ser Gly Val Glu Ala Phe Thr Gln Ile Ser Arg 
225                 230                 235                 240 


Glu Ile Gly Gly Val Cys Ile Ala Gln Ser Gln Lys Ile Pro Arg Glu 
                245                 250                 255     


Pro Arg Pro Gly Glu Phe Glu Lys Ile Ile Lys Arg Leu Leu Glu Thr 
            260                 265                 270         


Pro Asn Ala Arg Ala Val Ile Met Phe Ala Asn Glu Asp Asp Ile Arg 
        275                 280                 285             


Arg Ile Leu Glu Ala Ala Lys Lys Leu Asn Gln Ser Gly His Phe Leu 
    290                 295                 300                 


Trp Ile Gly Ser Asp Ser Trp Gly Ser Lys Ile Ala Pro Val Tyr Gln 
305                 310                 315                 320 


Gln Glu Glu Ile Ala Glu Gly Ala Val Thr Ile Leu Pro Lys Arg Ala 
                325                 330                 335     


Ser Ile Asp Gly Phe Asp Arg Tyr Phe Arg Ser Arg Thr Leu Ala Asn 
            340                 345                 350         


Asn Arg Arg Asn Val Trp Phe Ala Glu Phe Trp Glu Glu Asn Phe Gly 
        355                 360                 365             


Cys Lys Leu Gly Ser His Gly Lys Arg Asn Ser His Ile Lys Lys Cys 
    370                 375                 380                 


Thr Gly Leu Glu Arg Ile Ala Arg Asp Ser Ser Tyr Glu Gln Glu Gly 
385                 390                 395                 400 


Lys Val Gln Phe Val Ile Asp Ala Val Tyr Ser Met Ala Tyr Ala Leu 
                405                 410                 415     


His Asn Met His Lys Asp Leu Cys Pro Gly Tyr Ile Gly Leu Cys Pro 
            420                 425                 430         


Arg Met Ser Thr Ile Asp Gly Lys Glu Leu Leu Gly Tyr Ile Arg Ala 
        435                 440                 445             


Val Asn Phe Asn Gly Ser Ala Gly Thr Pro Val Thr Phe Asn Glu Asn 
    450                 455                 460                 


Gly Asp Ala Pro Gly Arg Tyr Asp Ile Phe Gln Tyr Gln Ile Thr Asn 
465                 470                 475                 480 


Lys Ser Thr Glu Tyr Lys Val Ile Gly His Trp Thr Asn Gln Leu His 
                485                 490                 495     


Leu Lys Val Glu Asp Met Gln Trp Ala His Arg Glu His Thr His Pro 
            500                 505                 510         


Ala Ser Val Cys Ser Leu Pro Cys Lys Pro Gly Glu Arg Lys Lys Thr 
        515                 520                 525             


Val Lys Gly Val Pro Cys Cys Trp His Cys Glu Arg Cys Glu Gly Tyr 
    530                 535                 540                 


Asn Tyr Gln Val Asp Glu Leu Ser Cys Glu Leu Cys Pro Leu Asp Gln 
545                 550                 555                 560 


Arg Pro Asn Met Asn Arg Thr Gly Cys Gln Leu Ile Pro Ile Ile Lys 
                565                 570                 575     


Leu Glu Trp His Ser Pro Trp Ala Val Val Pro Val Phe Val Ala Ile 
            580                 585                 590         


Leu Gly Ile Ile Ala Thr Thr Phe Val Ile Val Thr Phe Val Arg Tyr 
        595                 600                 605             


Asn Asp Thr Pro Ile Val Arg Ala Ser Gly Arg Glu Leu Ser Tyr Val 
    610                 615                 620                 


Leu Leu Thr Gly Ile Phe Leu Cys Tyr Ser Ile Thr Phe Leu Met Ile 
625                 630                 635                 640 


Ala Ala Pro Asp Thr Ile Ile Cys Ser Phe Arg Arg Val Phe Leu Gly 
                645                 650                 655     


Leu Gly Met Cys Phe Ser Tyr Ala Ala Leu Leu Thr Lys Thr Asn Arg 
            660                 665                 670         


Ile His Arg Ile Phe Glu Gln Gly Lys Lys Ser Val Thr Ala Pro Lys 
        675                 680                 685             


Phe Ile Ser Pro Ala Ser Gln Leu Val Ile Thr Phe Ser Leu Ile Ser 
    690                 695                 700                 


Val Gln Leu Leu Gly Val Phe Val Trp Phe Val Val Asp Pro Pro His 
705                 710                 715                 720 


Ile Ile Ile Asp Tyr Gly Glu Gln Arg Thr Leu Asp Pro Glu Lys Ala 
                725                 730                 735     


Arg Gly Val Leu Lys Cys Asp Ile Ser Asp Leu Ser Leu Ile Cys Ser 
            740                 745                 750         


Leu Gly Tyr Ser Ile Leu Leu Met Val Thr Cys Thr Val Tyr Ala Ile 
        755                 760                 765             


Lys Thr Arg Gly Val Pro Glu Thr Phe Asn Glu Ala Lys Pro Ile Gly 
    770                 775                 780                 


Phe Thr Met Tyr Thr Thr Cys Ile Ile Trp Leu Ala Phe Ile Pro Ile 
785                 790                 795                 800 


Phe Phe Gly Thr Ala Gln Ser Ala Glu Lys Met Tyr Ile Gln Thr Thr 
                805                 810                 815     


Thr Leu Thr Val Ser Met Ser Leu Ser Ala Ser Val Ser Leu Gly Met 
            820                 825                 830         


Leu Tyr Met Pro Lys Val Tyr Ile Ile Ile Phe His Pro Glu Gln Asn 
        835                 840                 845             


Val Gln Lys Arg Lys Arg Ser Phe Lys Ala Val Val Thr Ala Ala Thr 
    850                 855                 860                 


Met Gln Ser Lys Leu Ile Gln Lys Gly Asn Asp Arg Pro Asn Gly Glu 
865                 870                 875                 880 


Val Lys Ser Glu Leu Cys Glu Ser Leu Glu Thr Asn Thr Ser Ser Thr 
                885                 890                 895     


Lys Thr Thr Tyr Ile Ser Tyr Ser Asn His Ser Ile 
            900                 905             

<210>  352
<211>  3905
<212>  DNA
<213>  Homo sapiens

<400>  352
gacagatacc ctccttccgg ccgcgccact cgggaggcgg atcccgtggg cctgaggagg     60

cttcccccgc ccggtttgct ttccctccct cgctggcgct gccgcgagtc caccgagcgg    120

cctctgagga gcagccgcag gaggaggagg aggtcgtcgg gggcggcggg cggagaccgc    180

gctctcgctt ccccggcggc ggcaagggca ggacaatgga ggtggcggtg gagaaggcgg    240

tggcggcggc ggcagcggcc tcggctgcgg cctccggggg gccctcggcg gcgccgagcg    300

gggagaacga ggccgagagt cggcagggcc cggactcgga gcgcggcggc gaggcggccc    360

ggctcaacct gttggacact tgcgccgtgt gccaccagaa catccagagc cgggcgccca    420

agctgctgcc ctgcctgcac tctttctgcc agcgctgcct gcccgcgccc cagcgctacc    480

tcatgctgcc cgcgcccatg ctgggctcgg ccgagacccc gccacccgtc cctgcccccg    540

gctcgccggt cagcggctcg tcgccgttcg ccacccaagt tggagtcatt cgttgcccag    600

tttgcagcca agaatgtgca gagagacaca tcatagataa cttttttgtg aaggacacta    660

ctgaggttcc cagcagtaca gtagaaaagt caaatcaggt atgtacaagc tgtgaggaca    720

acgcagaagc caatgggttt tgtgtagagt gtgttgaatg gctctgcaag acgtgtatca    780

gagctcatca gagggtaaag ttcacaaaag accacactgt cagacagaaa gaggaagtat    840

ctccagaggc agttggtgtc accagccagc gaccagtgtt ttgtcctttt cataaaaagg    900

agcagctgaa gctgtactgt gagacatgtg acaaactgac atgtcgagac tgtcagttgt    960

tagaacataa agagcataga taccaattta tagaagaagc ttttcagaat cagaaagtga   1020

tcatagatac actaatcacc aaactgatgg aaaaaacaaa atacataaaa ttcacaggaa   1080

atcagatcca aaacagaatt attgaagtaa atcaaaatca aaagcaggtg gaacaggata   1140

ttaaagttgc tatatttaca ctgatggtag aaataaataa aaaaggaaaa gctctactgc   1200

atcagttaga gagccttgca aaggaccatc gcatgaaact tatgcaacaa caacaggaag   1260

tggctggact ctctaaacaa ttggagcatg tcatgcattt ttctaaatgg gcagtttcca   1320

gtggcagcag tacagcatta ctttatagca aacgactgat tacataccgg ttacggcacc   1380

tccttcgtgc aaggtgtgat gcatccccag tgaccaacaa caccatccaa tttcactgtg   1440

atcctagttt ctgggctcaa aatatcatca acttaggttc tttagtaatc gaggataaag   1500

agagccagcc acaaatgcct aagcagaatc ctgtcgtgga acagaattca cagccaccaa   1560

gtggtttatc atcaaaccag ttatccaagt tcccaacaca gatcagccta gctcaattac   1620

ggctccagca tatgcagcaa cagcaaccgc ctccacgttt gataaacttt cagaatcaca   1680

gccccaaacc caatggacca gttcttcctc ctcatcctca acaactgaga tatccaccaa   1740

accagaacat accacgacaa gcaataaagc caaaccccct acagatggct ttcttggctc   1800

aacaagccat aaaacagtgg cagatcagca gtggacaggg aaccccatca actaccaaca   1860

gcacatcctc tactccttcc agccccacga ttactagtgc agcaggatat gatggaaagg   1920

cttttggttc acctatgatc gatttgagct caccagtggg agggtcttat aatcttccct   1980

ctcttccgga tattgactgt tcaagtacta ttatgctgga caatattgtg aggaaagata   2040

ctaatataga tcatggccag ccaagaccac cctcaaacag aacggtccag tcaccaaatt   2100

catcagtgcc atctccaggc cttgcaggac ctgttactat gactagtgta caccccccaa   2160

tacgttcacc tagtgcctcc agcgttggaa gccgaggaag ctctggctct tccagcaaac   2220

cagcaggagc tgactctaca cacaaagtcc cagtggtcat gctggagcca attcgaataa   2280

aacaagaaaa cagtggacca ccggaaaatt atgatttccc tgttgttata gtgaagcaag   2340

aatcagatga agaatctagg cctcaaaatg ccaattatcc aagaagcata ctcacctccc   2400

tgctcttaaa tagcagtcag agctctactt ctgaggagac tgtgctaaga tcagatgccc   2460

ctgatagtac aggagatcaa cctggacttc accaggacaa ttcctcaaat ggaaagtctg   2520

aatggttgga tccttcccag aagtcacctc ttcatgttgg agagacaagg aaagaggatg   2580

accccaatga ggactggtgt gcagtttgtc aaaacggagg ggaactcctc tgctgtgaaa   2640

agtgccccaa agtattccat ctttcttgtc atgtgcccac attgacaaat tttccaagtg   2700

gagagtggat ttgcactttc tgccgagact tatctaaacc agaagttgaa tatgattgtg   2760

atgctcccag tcacaactca gaaaaaaaga aaactgaagg ccttgttaag ttaacaccta   2820

tagataaaag gaagtgtgag cgcctacttt tatttcttta ctgccatgaa atgagcctgg   2880

cttttcaaga ccctgttcct ctaactgtgc ctgattatta caaaataatt aaaaatccaa   2940

tggatttgtc aaccatcaag aaaagactac aagaagatta ttccatgtac tcaaaacctg   3000

aagattttgt agctgatttt agattgatct ttcaaaactg tgctgaattc aatgagcctg   3060

attcagaagt agccaatgct ggtataaaac ttgaaaatta ttttgaagaa cttctaaaga   3120

acctctatcc agaaaaaagg tttcccaaac cagaattcag gaatgaatca gaagataata   3180

aatttagtga tgattcagat gatgactttg tacagccccg gaagaaacgc ctcaaaagca   3240

ttgaagaacg ccagttgctt aaataatatg cagcaccact agcttgtgct ggtttttaga   3300

tttttttgtt ttcaaaaaaa catttgtcag taatttaaca tcactacaaa aagaagagtt   3360

tgtgactatt ctcatctctg ttttggacgt ttactagact ttgatttcct taatagccca   3420

tttctgttaa cctcttatca ctaagaaaga aaggaaagaa ggagatgaat agaagaaaga   3480

aaatggaaag aaggaaaaaa ggaggataga aaaaggatgg aagaaagaag cattgaaaac   3540

aaagacattc ttcccacttc ttggattttt aaaccacagt ctggagtgat agctactgta   3600

gaaaggaaat agactttgta tgaactcttt aagttgaaaa gtaaaaaata tatgtggttt   3660

ggatgtgtgc tttaattcag ctttagaaat taataccact acccgtgaat tatatggcct   3720

gacaatatga attaggtgta ctgtactgaa gaacagtact ccacaaacat gggtggtaac   3780

aagagttcca tcccaggagg ccaaacggtg caacagaagg gtaggttaga tgctattaag   3840

aaggcactta atagtacatc atgtaagatg gcaactgtat taaagaaaaa tccggaaaac   3900

aaaaa                                                               3905


<210>  353
<211>  1016
<212>  PRT
<213>  Homo sapiens

<400>  353


Met Glu Val Ala Val Glu Lys Ala Val Ala Ala Ala Ala Ala Ala Ser 
1               5                   10                  15      


Ala Ala Ala Ser Gly Gly Pro Ser Ala Ala Pro Ser Gly Glu Asn Glu 
            20                  25                  30          


Ala Glu Ser Arg Gln Gly Pro Asp Ser Glu Arg Gly Gly Glu Ala Ala 
        35                  40                  45              


Arg Leu Asn Leu Leu Asp Thr Cys Ala Val Cys His Gln Asn Ile Gln 
    50                  55                  60                  


Ser Arg Ala Pro Lys Leu Leu Pro Cys Leu His Ser Phe Cys Gln Arg 
65                  70                  75                  80  


Cys Leu Pro Ala Pro Gln Arg Tyr Leu Met Leu Pro Ala Pro Met Leu 
                85                  90                  95      


Gly Ser Ala Glu Thr Pro Pro Pro Val Pro Ala Pro Gly Ser Pro Val 
            100                 105                 110         


Ser Gly Ser Ser Pro Phe Ala Thr Gln Val Gly Val Ile Arg Cys Pro 
        115                 120                 125             


Val Cys Ser Gln Glu Cys Ala Glu Arg His Ile Ile Asp Asn Phe Phe 
    130                 135                 140                 


Val Lys Asp Thr Thr Glu Val Pro Ser Ser Thr Val Glu Lys Ser Asn 
145                 150                 155                 160 


Gln Val Cys Thr Ser Cys Glu Asp Asn Ala Glu Ala Asn Gly Phe Cys 
                165                 170                 175     


Val Glu Cys Val Glu Trp Leu Cys Lys Thr Cys Ile Arg Ala His Gln 
            180                 185                 190         


Arg Val Lys Phe Thr Lys Asp His Thr Val Arg Gln Lys Glu Glu Val 
        195                 200                 205             


Ser Pro Glu Ala Val Gly Val Thr Ser Gln Arg Pro Val Phe Cys Pro 
    210                 215                 220                 


Phe His Lys Lys Glu Gln Leu Lys Leu Tyr Cys Glu Thr Cys Asp Lys 
225                 230                 235                 240 


Leu Thr Cys Arg Asp Cys Gln Leu Leu Glu His Lys Glu His Arg Tyr 
                245                 250                 255     


Gln Phe Ile Glu Glu Ala Phe Gln Asn Gln Lys Val Ile Ile Asp Thr 
            260                 265                 270         


Leu Ile Thr Lys Leu Met Glu Lys Thr Lys Tyr Ile Lys Phe Thr Gly 
        275                 280                 285             


Asn Gln Ile Gln Asn Arg Ile Ile Glu Val Asn Gln Asn Gln Lys Gln 
    290                 295                 300                 


Val Glu Gln Asp Ile Lys Val Ala Ile Phe Thr Leu Met Val Glu Ile 
305                 310                 315                 320 


Asn Lys Lys Gly Lys Ala Leu Leu His Gln Leu Glu Ser Leu Ala Lys 
                325                 330                 335     


Asp His Arg Met Lys Leu Met Gln Gln Gln Gln Glu Val Ala Gly Leu 
            340                 345                 350         


Ser Lys Gln Leu Glu His Val Met His Phe Ser Lys Trp Ala Val Ser 
        355                 360                 365             


Ser Gly Ser Ser Thr Ala Leu Leu Tyr Ser Lys Arg Leu Ile Thr Tyr 
    370                 375                 380                 


Arg Leu Arg His Leu Leu Arg Ala Arg Cys Asp Ala Ser Pro Val Thr 
385                 390                 395                 400 


Asn Asn Thr Ile Gln Phe His Cys Asp Pro Ser Phe Trp Ala Gln Asn 
                405                 410                 415     


Ile Ile Asn Leu Gly Ser Leu Val Ile Glu Asp Lys Glu Ser Gln Pro 
            420                 425                 430         


Gln Met Pro Lys Gln Asn Pro Val Val Glu Gln Asn Ser Gln Pro Pro 
        435                 440                 445             


Ser Gly Leu Ser Ser Asn Gln Leu Ser Lys Phe Pro Thr Gln Ile Ser 
    450                 455                 460                 


Leu Ala Gln Leu Arg Leu Gln His Met Gln Gln Gln Gln Pro Pro Pro 
465                 470                 475                 480 


Arg Leu Ile Asn Phe Gln Asn His Ser Pro Lys Pro Asn Gly Pro Val 
                485                 490                 495     


Leu Pro Pro His Pro Gln Gln Leu Arg Tyr Pro Pro Asn Gln Asn Ile 
            500                 505                 510         


Pro Arg Gln Ala Ile Lys Pro Asn Pro Leu Gln Met Ala Phe Leu Ala 
        515                 520                 525             


Gln Gln Ala Ile Lys Gln Trp Gln Ile Ser Ser Gly Gln Gly Thr Pro 
    530                 535                 540                 


Ser Thr Thr Asn Ser Thr Ser Ser Thr Pro Ser Ser Pro Thr Ile Thr 
545                 550                 555                 560 


Ser Ala Ala Gly Tyr Asp Gly Lys Ala Phe Gly Ser Pro Met Ile Asp 
                565                 570                 575     


Leu Ser Ser Pro Val Gly Gly Ser Tyr Asn Leu Pro Ser Leu Pro Asp 
            580                 585                 590         


Ile Asp Cys Ser Ser Thr Ile Met Leu Asp Asn Ile Val Arg Lys Asp 
        595                 600                 605             


Thr Asn Ile Asp His Gly Gln Pro Arg Pro Pro Ser Asn Arg Thr Val 
    610                 615                 620                 


Gln Ser Pro Asn Ser Ser Val Pro Ser Pro Gly Leu Ala Gly Pro Val 
625                 630                 635                 640 


Thr Met Thr Ser Val His Pro Pro Ile Arg Ser Pro Ser Ala Ser Ser 
                645                 650                 655     


Val Gly Ser Arg Gly Ser Ser Gly Ser Ser Ser Lys Pro Ala Gly Ala 
            660                 665                 670         


Asp Ser Thr His Lys Val Pro Val Val Met Leu Glu Pro Ile Arg Ile 
        675                 680                 685             


Lys Gln Glu Asn Ser Gly Pro Pro Glu Asn Tyr Asp Phe Pro Val Val 
    690                 695                 700                 


Ile Val Lys Gln Glu Ser Asp Glu Glu Ser Arg Pro Gln Asn Ala Asn 
705                 710                 715                 720 


Tyr Pro Arg Ser Ile Leu Thr Ser Leu Leu Leu Asn Ser Ser Gln Ser 
                725                 730                 735     


Ser Thr Ser Glu Glu Thr Val Leu Arg Ser Asp Ala Pro Asp Ser Thr 
            740                 745                 750         


Gly Asp Gln Pro Gly Leu His Gln Asp Asn Ser Ser Asn Gly Lys Ser 
        755                 760                 765             


Glu Trp Leu Asp Pro Ser Gln Lys Ser Pro Leu His Val Gly Glu Thr 
    770                 775                 780                 


Arg Lys Glu Asp Asp Pro Asn Glu Asp Trp Cys Ala Val Cys Gln Asn 
785                 790                 795                 800 


Gly Gly Glu Leu Leu Cys Cys Glu Lys Cys Pro Lys Val Phe His Leu 
                805                 810                 815     


Ser Cys His Val Pro Thr Leu Thr Asn Phe Pro Ser Gly Glu Trp Ile 
            820                 825                 830         


Cys Thr Phe Cys Arg Asp Leu Ser Lys Pro Glu Val Glu Tyr Asp Cys 
        835                 840                 845             


Asp Ala Pro Ser His Asn Ser Glu Lys Lys Lys Thr Glu Gly Leu Val 
    850                 855                 860                 


Lys Leu Thr Pro Ile Asp Lys Arg Lys Cys Glu Arg Leu Leu Leu Phe 
865                 870                 875                 880 


Leu Tyr Cys His Glu Met Ser Leu Ala Phe Gln Asp Pro Val Pro Leu 
                885                 890                 895     


Thr Val Pro Asp Tyr Tyr Lys Ile Ile Lys Asn Pro Met Asp Leu Ser 
            900                 905                 910         


Thr Ile Lys Lys Arg Leu Gln Glu Asp Tyr Ser Met Tyr Ser Lys Pro 
        915                 920                 925             


Glu Asp Phe Val Ala Asp Phe Arg Leu Ile Phe Gln Asn Cys Ala Glu 
    930                 935                 940                 


Phe Asn Glu Pro Asp Ser Glu Val Ala Asn Ala Gly Ile Lys Leu Glu 
945                 950                 955                 960 


Asn Tyr Phe Glu Glu Leu Leu Lys Asn Leu Tyr Pro Glu Lys Arg Phe 
                965                 970                 975     


Pro Lys Pro Glu Phe Arg Asn Glu Ser Glu Asp Asn Lys Phe Ser Asp 
            980                 985                 990         


Asp Ser Asp Asp Asp Phe Val Gln  Pro Arg Lys Lys Arg  Leu Lys Ser 
        995                 1000                 1005             


Ile Glu  Glu Arg Gln Leu Leu  Lys 
    1010                 1015     

<210>  354
<211>  4007
<212>  DNA
<213>  Homo sapiens

<400>  354
gacagatacc ctccttccgg ccgcgccact cgggaggcgg atcccgtggg cctgaggagg     60

cttcccccgc ccggtttgct ttccctccct cgctggcgct gccgcgagtc caccgagcgg    120

cctctgagga gcagccgcag gaggaggagg aggtcgtcgg gggcggcggg cggagaccgc    180

gctctcgctt ccccggcggc ggcaagggca ggacaatgga ggtggcggtg gagaaggcgg    240

tggcggcggc ggcagcggcc tcggctgcgg cctccggggg gccctcggcg gcgccgagcg    300

gggagaacga ggccgagagt cggcagggcc cggactcgga gcgcggcggc gaggcggccc    360

ggctcaacct gttggacact tgcgccgtgt gccaccagaa catccagagc cgggcgccca    420

agctgctgcc ctgcctgcac tctttctgcc agcgctgcct gcccgcgccc cagcgctacc    480

tcatgctgcc cgcgcccatg ctgggctcgg ccgagacccc gccacccgtc cctgcccccg    540

gctcgccggt cagcggctcg tcgccgttcg ccacccaagt tggagtcatt cgttgcccag    600

tttgcagcca agaatgtgca gagagacaca tcatagataa cttttttgtg aaggacacta    660

ctgaggttcc cagcagtaca gtagaaaagt caaatcaggt atgtacaagc tgtgaggaca    720

acgcagaagc caatgggttt tgtgtagagt gtgttgaatg gctctgcaag acgtgtatca    780

gagctcatca gagggtaaag ttcacaaaag accacactgt cagacagaaa gaggaagtat    840

ctccagaggc agttggtgtc accagccagc gaccagtgtt ttgtcctttt cataaaaagg    900

agcagctgaa gctgtactgt gagacatgtg acaaactgac atgtcgagac tgtcagttgt    960

tagaacataa agagcataga taccaattta tagaagaagc ttttcagaat cagaaagtga   1020

tcatagatac actaatcacc aaactgatgg aaaaaacaaa atacataaaa ttcacaggaa   1080

atcagatcca aaacagaatt attgaagtaa atcaaaatca aaagcaggtg gaacaggata   1140

ttaaagttgc tatatttaca ctgatggtag aaataaataa aaaaggaaaa gctctactgc   1200

atcagttaga gagccttgca aaggaccatc gcatgaaact tatgcaacaa caacaggaag   1260

tggctggact ctctaaacaa ttggagcatg tcatgcattt ttctaaatgg gcagtttcca   1320

gtggcagcag tacagcatta ctttatagca aacgactgat tacataccgg ttacggcacc   1380

tccttcgtgc aaggtgtgat gcatccccag tgaccaacaa caccatccaa tttcactgtg   1440

atcctagttt ctgggctcaa aatatcatca acttaggttc tttagtaatc gaggataaag   1500

agagccagcc acaaatgcct aagcagaatc ctgtcgtgga acagaattca cagccaccaa   1560

gtggtttatc atcaaaccag ttatccaagt tcccaacaca gatcagccta gctcaattac   1620

ggctccagca tatgcagcaa caggtaatgg ctcagaggca acaggtgcaa cggaggccag   1680

cacctgtggg tttaccaaac cctagaatgc aggggcccat ccagcaacct tccatctctc   1740

atcagcaacc gcctccacgt ttgataaact ttcagaatca cagccccaaa cccaatggac   1800

cagttcttcc tcctcatcct caacaactga gatatccacc aaaccagaac ataccacgac   1860

aagcaataaa gccaaacccc ctacagatgg ctttcttggc tcaacaagcc ataaaacagt   1920

ggcagatcag cagtggacag ggaaccccat caactaccaa cagcacatcc tctactcctt   1980

ccagccccac gattactagt gcagcaggat atgatggaaa ggcttttggt tcacctatga   2040

tcgatttgag ctcaccagtg ggagggtctt ataatcttcc ctctcttccg gatattgact   2100

gttcaagtac tattatgctg gacaatattg tgaggaaaga tactaatata gatcatggcc   2160

agccaagacc accctcaaac agaacggtcc agtcaccaaa ttcatcagtg ccatctccag   2220

gccttgcagg acctgttact atgactagtg tacacccccc aatacgttca cctagtgcct   2280

ccagcgttgg aagccgagga agctctggct cttccagcaa accagcagga gctgactcta   2340

cacacaaagt cccagtggtc atgctggagc caattcgaat aaaacaagaa aacagtggac   2400

caccggaaaa ttatgatttc cctgttgtta tagtgaagca agaatcagat gaagaatcta   2460

ggcctcaaaa tgccaattat ccaagaagca tactcacctc cctgctctta aatagcagtc   2520

agagctctac ttctgaggag actgtgctaa gatcagatgc ccctgatagt acaggagatc   2580

aacctggact tcaccaggac aattcctcaa atggaaagtc tgaatggttg gatccttccc   2640

agaagtcacc tcttcatgtt ggagagacaa ggaaagagga tgaccccaat gaggactggt   2700

gtgcagtttg tcaaaacgga ggggaactcc tctgctgtga aaagtgcccc aaagtattcc   2760

atctttcttg tcatgtgccc acattgacaa attttccaag tggagagtgg atttgcactt   2820

tctgccgaga cttatctaaa ccagaagttg aatatgattg tgatgctccc agtcacaact   2880

cagaaaaaaa gaaaactgaa ggccttgtta agttaacacc tatagataaa aggaagtgtg   2940

agcgcctact tttatttctt tactgccatg aaatgagcct ggcttttcaa gaccctgttc   3000

ctctaactgt gcctgattat tacaaaataa ttaaaaatcc aatggatttg tcaaccatca   3060

agaaaagact acaagaagat tattccatgt actcaaaacc tgaagatttt gtagctgatt   3120

ttagattgat ctttcaaaac tgtgctgaat tcaatgagcc tgattcagaa gtagccaatg   3180

ctggtataaa acttgaaaat tattttgaag aacttctaaa gaacctctat ccagaaaaaa   3240

ggtttcccaa accagaattc aggaatgaat cagaagataa taaatttagt gatgattcag   3300

atgatgactt tgtacagccc cggaagaaac gcctcaaaag cattgaagaa cgccagttgc   3360

ttaaataata tgcagcacca ctagcttgtg ctggttttta gatttttttg ttttcaaaaa   3420

aacatttgtc agtaatttaa catcactaca aaaagaagag tttgtgacta ttctcatctc   3480

tgttttggac gtttactaga ctttgatttc cttaatagcc catttctgtt aacctcttat   3540

cactaagaaa gaaaggaaag aaggagatga atagaagaaa gaaaatggaa agaaggaaaa   3600

aaggaggata gaaaaaggat ggaagaaaga agcattgaaa acaaagacat tcttcccact   3660

tcttggattt ttaaaccaca gtctggagtg atagctactg tagaaaggaa atagactttg   3720

tatgaactct ttaagttgaa aagtaaaaaa tatatgtggt ttggatgtgt gctttaattc   3780

agctttagaa attaatacca ctacccgtga attatatggc ctgacaatat gaattaggtg   3840

tactgtactg aagaacagta ctccacaaac atgggtggta acaagagttc catcccagga   3900

ggccaaacgg tgcaacagaa gggtaggtta gatgctatta agaaggcact taatagtaca   3960

tcatgtaaga tggcaactgt attaaagaaa aatccggaaa acaaaaa                 4007


<210>  355
<211>  1050
<212>  PRT
<213>  Homo sapiens

<400>  355


Met Glu Val Ala Val Glu Lys Ala Val Ala Ala Ala Ala Ala Ala Ser 
1               5                   10                  15      


Ala Ala Ala Ser Gly Gly Pro Ser Ala Ala Pro Ser Gly Glu Asn Glu 
            20                  25                  30          


Ala Glu Ser Arg Gln Gly Pro Asp Ser Glu Arg Gly Gly Glu Ala Ala 
        35                  40                  45              


Arg Leu Asn Leu Leu Asp Thr Cys Ala Val Cys His Gln Asn Ile Gln 
    50                  55                  60                  


Ser Arg Ala Pro Lys Leu Leu Pro Cys Leu His Ser Phe Cys Gln Arg 
65                  70                  75                  80  


Cys Leu Pro Ala Pro Gln Arg Tyr Leu Met Leu Pro Ala Pro Met Leu 
                85                  90                  95      


Gly Ser Ala Glu Thr Pro Pro Pro Val Pro Ala Pro Gly Ser Pro Val 
            100                 105                 110         


Ser Gly Ser Ser Pro Phe Ala Thr Gln Val Gly Val Ile Arg Cys Pro 
        115                 120                 125             


Val Cys Ser Gln Glu Cys Ala Glu Arg His Ile Ile Asp Asn Phe Phe 
    130                 135                 140                 


Val Lys Asp Thr Thr Glu Val Pro Ser Ser Thr Val Glu Lys Ser Asn 
145                 150                 155                 160 


Gln Val Cys Thr Ser Cys Glu Asp Asn Ala Glu Ala Asn Gly Phe Cys 
                165                 170                 175     


Val Glu Cys Val Glu Trp Leu Cys Lys Thr Cys Ile Arg Ala His Gln 
            180                 185                 190         


Arg Val Lys Phe Thr Lys Asp His Thr Val Arg Gln Lys Glu Glu Val 
        195                 200                 205             


Ser Pro Glu Ala Val Gly Val Thr Ser Gln Arg Pro Val Phe Cys Pro 
    210                 215                 220                 


Phe His Lys Lys Glu Gln Leu Lys Leu Tyr Cys Glu Thr Cys Asp Lys 
225                 230                 235                 240 


Leu Thr Cys Arg Asp Cys Gln Leu Leu Glu His Lys Glu His Arg Tyr 
                245                 250                 255     


Gln Phe Ile Glu Glu Ala Phe Gln Asn Gln Lys Val Ile Ile Asp Thr 
            260                 265                 270         


Leu Ile Thr Lys Leu Met Glu Lys Thr Lys Tyr Ile Lys Phe Thr Gly 
        275                 280                 285             


Asn Gln Ile Gln Asn Arg Ile Ile Glu Val Asn Gln Asn Gln Lys Gln 
    290                 295                 300                 


Val Glu Gln Asp Ile Lys Val Ala Ile Phe Thr Leu Met Val Glu Ile 
305                 310                 315                 320 


Asn Lys Lys Gly Lys Ala Leu Leu His Gln Leu Glu Ser Leu Ala Lys 
                325                 330                 335     


Asp His Arg Met Lys Leu Met Gln Gln Gln Gln Glu Val Ala Gly Leu 
            340                 345                 350         


Ser Lys Gln Leu Glu His Val Met His Phe Ser Lys Trp Ala Val Ser 
        355                 360                 365             


Ser Gly Ser Ser Thr Ala Leu Leu Tyr Ser Lys Arg Leu Ile Thr Tyr 
    370                 375                 380                 


Arg Leu Arg His Leu Leu Arg Ala Arg Cys Asp Ala Ser Pro Val Thr 
385                 390                 395                 400 


Asn Asn Thr Ile Gln Phe His Cys Asp Pro Ser Phe Trp Ala Gln Asn 
                405                 410                 415     


Ile Ile Asn Leu Gly Ser Leu Val Ile Glu Asp Lys Glu Ser Gln Pro 
            420                 425                 430         


Gln Met Pro Lys Gln Asn Pro Val Val Glu Gln Asn Ser Gln Pro Pro 
        435                 440                 445             


Ser Gly Leu Ser Ser Asn Gln Leu Ser Lys Phe Pro Thr Gln Ile Ser 
    450                 455                 460                 


Leu Ala Gln Leu Arg Leu Gln His Met Gln Gln Gln Val Met Ala Gln 
465                 470                 475                 480 


Arg Gln Gln Val Gln Arg Arg Pro Ala Pro Val Gly Leu Pro Asn Pro 
                485                 490                 495     


Arg Met Gln Gly Pro Ile Gln Gln Pro Ser Ile Ser His Gln Gln Pro 
            500                 505                 510         


Pro Pro Arg Leu Ile Asn Phe Gln Asn His Ser Pro Lys Pro Asn Gly 
        515                 520                 525             


Pro Val Leu Pro Pro His Pro Gln Gln Leu Arg Tyr Pro Pro Asn Gln 
    530                 535                 540                 


Asn Ile Pro Arg Gln Ala Ile Lys Pro Asn Pro Leu Gln Met Ala Phe 
545                 550                 555                 560 


Leu Ala Gln Gln Ala Ile Lys Gln Trp Gln Ile Ser Ser Gly Gln Gly 
                565                 570                 575     


Thr Pro Ser Thr Thr Asn Ser Thr Ser Ser Thr Pro Ser Ser Pro Thr 
            580                 585                 590         


Ile Thr Ser Ala Ala Gly Tyr Asp Gly Lys Ala Phe Gly Ser Pro Met 
        595                 600                 605             


Ile Asp Leu Ser Ser Pro Val Gly Gly Ser Tyr Asn Leu Pro Ser Leu 
    610                 615                 620                 


Pro Asp Ile Asp Cys Ser Ser Thr Ile Met Leu Asp Asn Ile Val Arg 
625                 630                 635                 640 


Lys Asp Thr Asn Ile Asp His Gly Gln Pro Arg Pro Pro Ser Asn Arg 
                645                 650                 655     


Thr Val Gln Ser Pro Asn Ser Ser Val Pro Ser Pro Gly Leu Ala Gly 
            660                 665                 670         


Pro Val Thr Met Thr Ser Val His Pro Pro Ile Arg Ser Pro Ser Ala 
        675                 680                 685             


Ser Ser Val Gly Ser Arg Gly Ser Ser Gly Ser Ser Ser Lys Pro Ala 
    690                 695                 700                 


Gly Ala Asp Ser Thr His Lys Val Pro Val Val Met Leu Glu Pro Ile 
705                 710                 715                 720 


Arg Ile Lys Gln Glu Asn Ser Gly Pro Pro Glu Asn Tyr Asp Phe Pro 
                725                 730                 735     


Val Val Ile Val Lys Gln Glu Ser Asp Glu Glu Ser Arg Pro Gln Asn 
            740                 745                 750         


Ala Asn Tyr Pro Arg Ser Ile Leu Thr Ser Leu Leu Leu Asn Ser Ser 
        755                 760                 765             


Gln Ser Ser Thr Ser Glu Glu Thr Val Leu Arg Ser Asp Ala Pro Asp 
    770                 775                 780                 


Ser Thr Gly Asp Gln Pro Gly Leu His Gln Asp Asn Ser Ser Asn Gly 
785                 790                 795                 800 


Lys Ser Glu Trp Leu Asp Pro Ser Gln Lys Ser Pro Leu His Val Gly 
                805                 810                 815     


Glu Thr Arg Lys Glu Asp Asp Pro Asn Glu Asp Trp Cys Ala Val Cys 
            820                 825                 830         


Gln Asn Gly Gly Glu Leu Leu Cys Cys Glu Lys Cys Pro Lys Val Phe 
        835                 840                 845             


His Leu Ser Cys His Val Pro Thr Leu Thr Asn Phe Pro Ser Gly Glu 
    850                 855                 860                 


Trp Ile Cys Thr Phe Cys Arg Asp Leu Ser Lys Pro Glu Val Glu Tyr 
865                 870                 875                 880 


Asp Cys Asp Ala Pro Ser His Asn Ser Glu Lys Lys Lys Thr Glu Gly 
                885                 890                 895     


Leu Val Lys Leu Thr Pro Ile Asp Lys Arg Lys Cys Glu Arg Leu Leu 
            900                 905                 910         


Leu Phe Leu Tyr Cys His Glu Met Ser Leu Ala Phe Gln Asp Pro Val 
        915                 920                 925             


Pro Leu Thr Val Pro Asp Tyr Tyr Lys Ile Ile Lys Asn Pro Met Asp 
    930                 935                 940                 


Leu Ser Thr Ile Lys Lys Arg Leu Gln Glu Asp Tyr Ser Met Tyr Ser 
945                 950                 955                 960 


Lys Pro Glu Asp Phe Val Ala Asp Phe Arg Leu Ile Phe Gln Asn Cys 
                965                 970                 975     


Ala Glu Phe Asn Glu Pro Asp Ser Glu Val Ala Asn Ala Gly Ile Lys 
            980                 985                 990         


Leu Glu Asn Tyr Phe Glu Glu Leu  Leu Lys Asn Leu Tyr  Pro Glu Lys 
        995                 1000                 1005             


Arg Phe  Pro Lys Pro Glu Phe  Arg Asn Glu Ser Glu  Asp Asn Lys 
    1010                 1015                 1020             


Phe Ser  Asp Asp Ser Asp Asp  Asp Phe Val Gln Pro  Arg Lys Lys 
    1025                 1030                 1035             


Arg Leu  Lys Ser Ile Glu Glu  Arg Gln Leu Leu Lys  
    1040                 1045                 1050 

<210>  356
<211>  1500
<212>  DNA
<213>  Homo sapiens

<400>  356
caggacgtct tccagatggt gttttttggc tacatgattt tcagtatcct ctttggcctc     60

ctggctgaca gatatggccg ctggaaggtt aatcataaag actgaatttt tgcccacgaa    120

ataccgaggc tatatgttac ccttgtctca ggtgttctgg cttgcgggct ccctgctcat    180

cattggcttg gcctctgtga tcatccccac catcgggtgg cgctggctca ttcgcgtcgc    240

ctccatcccg ggcatcatcc tcatcgtggc cttcaagttt attcctgaat ctgcccggtt    300

caatgtctcc actgggaaca ctcgggctgc cctggccact ctggagcgcg ttgccaagat    360

gaaccgctcg gtcatgccgg aggggaagct ggtggagccc gtcctggaaa aaagaggaag    420

atttgcagac ctattggatg ctaaatattt acggaccaca ttacagatct gggtcatatg    480

gcttggaatc tcttttgcct actatggggt tatcctggcc agtgctgagc tgctggagcg    540

ggacttggtc tgtggttcaa agtcagactc tgcggtggtg gtgactgggg gggactcagg    600

ggagagccag agcccctgct actgccacat gtttgcaccc tctgactatc ggaccatgat    660

catcagcacc atcggtgaaa ttgctttgaa tcctttaaat atactgggca tcaatttcct    720

gggaagacgg ctgagccttt ctattaccat gggatgcacg gctttattct tccttctcct    780

caacatttgc acttcaagtg ccggcctgat tggcttcctc ttcatgctga gggctctggt    840

agctgcaaac ttcaacaccg tctacattta cacagctgag gtctacccca ccacgatgcg    900

cgctttgggg atgggaacca gcggctccct gtgtcgcatt ggtgcaatgg tggcgccatt    960

tatatcccag gttcttatga gtgcatcaat actgggggcc ctgtgtctct tctcatctgt   1020

ctgtgttgta tgcgccattt ctgcattcac tctccccatc gaaaccaaag gacgggccct   1080

ccagcaaatt aaatgaagac ctgcaaagct atgtctacca gatgagaaaa atgaattcta   1140

tcttcagaac tgcggtgcat ttttttaaaa cttggtttta cttctgtatg ctactcggta   1200

attagtaaag tgattttttt tttaaaggca tatatgggaa tggggtaggt aactgtatat   1260

tgatctcttc cttgaggaac aatatataaa gtacttttat aaaatataat ttaagctttc   1320

aaaggggtgt gagagggaga tggtgggggg gaagatggct tttcttcatt gaaatcaagt   1380

ctgtaaacct ttatatgaat aaatactaaa ttttaaactt aaaaaaaaaa aaaaaaaaaa   1440

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   1500


<210>  357
<211>  340
<212>  PRT
<213>  Homo sapiens

<400>  357


Met Ala Ala Gly Arg Leu Ile Ile Lys Thr Glu Phe Leu Pro Thr Lys 
1               5                   10                  15      


Tyr Arg Gly Tyr Met Leu Pro Leu Ser Gln Val Phe Trp Leu Ala Gly 
            20                  25                  30          


Ser Leu Leu Ile Ile Gly Leu Ala Ser Val Ile Ile Pro Thr Ile Gly 
        35                  40                  45              


Trp Arg Trp Leu Ile Arg Val Ala Ser Ile Pro Gly Ile Ile Leu Ile 
    50                  55                  60                  


Val Ala Phe Lys Phe Ile Pro Glu Ser Ala Arg Phe Asn Val Ser Thr 
65                  70                  75                  80  


Gly Asn Thr Arg Ala Ala Leu Ala Thr Leu Glu Arg Val Ala Lys Met 
                85                  90                  95      


Asn Arg Ser Val Met Pro Glu Gly Lys Leu Val Glu Pro Val Leu Glu 
            100                 105                 110         


Lys Arg Gly Arg Phe Ala Asp Leu Leu Asp Ala Lys Tyr Leu Arg Thr 
        115                 120                 125             


Thr Leu Gln Ile Trp Val Ile Trp Leu Gly Ile Ser Phe Ala Tyr Tyr 
    130                 135                 140                 


Gly Val Ile Leu Ala Ser Ala Glu Leu Leu Glu Arg Asp Leu Val Cys 
145                 150                 155                 160 


Gly Ser Lys Ser Asp Ser Ala Val Val Val Thr Gly Gly Asp Ser Gly 
                165                 170                 175     


Glu Ser Gln Ser Pro Cys Tyr Cys His Met Phe Ala Pro Ser Asp Tyr 
            180                 185                 190         


Arg Thr Met Ile Ile Ser Thr Ile Gly Glu Ile Ala Leu Asn Pro Leu 
        195                 200                 205             


Asn Ile Leu Gly Ile Asn Phe Leu Gly Arg Arg Leu Ser Leu Ser Ile 
    210                 215                 220                 


Thr Met Gly Cys Thr Ala Leu Phe Phe Leu Leu Leu Asn Ile Cys Thr 
225                 230                 235                 240 


Ser Ser Ala Gly Leu Ile Gly Phe Leu Phe Met Leu Arg Ala Leu Val 
                245                 250                 255     


Ala Ala Asn Phe Asn Thr Val Tyr Ile Tyr Thr Ala Glu Val Tyr Pro 
            260                 265                 270         


Thr Thr Met Arg Ala Leu Gly Met Gly Thr Ser Gly Ser Leu Cys Arg 
        275                 280                 285             


Ile Gly Ala Met Val Ala Pro Phe Ile Ser Gln Val Leu Met Ser Ala 
    290                 295                 300                 


Ser Ile Leu Gly Ala Leu Cys Leu Phe Ser Ser Val Cys Val Val Cys 
305                 310                 315                 320 


Ala Ile Ser Ala Phe Thr Leu Pro Ile Glu Thr Lys Gly Arg Ala Leu 
                325                 330                 335     


Gln Gln Ile Lys 
            340 

<210>  358
<211>  14320
<212>  DNA
<213>  Homo sapiens

<400>  358
cccactcgct ggctctctct ccagctgcct cctctccagg tctctcctgg ctgcgcgcgc     60

tcctctcccc gcttctcccc ctcccgcagc ctcgccgcct tggtgccttc ctgcccggct    120

cggccggcgc tcgtccccgg ccccggcccc gccagcccgg gtctccgcgc tcggagcagc    180

tcagccctgc agtggctcgg gacccgatgc tatgagaggg aagcgagccg ggcgcccaga    240

ccttcaggag gcgtcggatg cgcggcgggt cttgggaccg ggctctctct ccggctcgcc    300

ttgccctcgg gtgattattt ggctccgctc atagccctgc cttcctcgga ggagccatcg    360

gtgtcgcgtg cgtgtggagt atctgcagac atgactgcgt ggaggagatt ccagtcgctg    420

ctcctgcttc tcgggctgct ggtgctgtgc gcgaggctcc tcactgcagc gaagggtcag    480

aactgtggag gcttagtcca gggtcccaat ggcactattg agagcccagg gtttcctcac    540

gggtatccga actatgccaa ctgcacctgg atcatcatca cgggcgagcg caataggata    600

cagttgtcct tccatacctt tgctcttgaa gaagattttg atattttatc agtttacgat    660

ggacagcctc aacaagggaa tttaaaagtg agattatcgg gatttcagct gccctcctct    720

atagtgagta caggatctat cctcactctg tggttcacga cagacttcgc tgtgagtgcc    780

caaggtttca aagcattata tgaagtttta cctagccaca cttgtggaaa tcctggagaa    840

atcctgaaag gagttctgca tggaacgaga ttcaacatag gagacaaaat ccggtacagc    900

tgcctccctg gctacatctt ggaaggccac gccatcctga cctgcatcgt cagcccagga    960

aatggtgcat cgtgggactt cccagctccc ttttgcagag ctgagggagc ctgcggagga   1020

accttacgcg ggaccagcag ctccatctcc agcccgcact tcccttcaga gtacgagaac   1080

aacgcggact gcacctggac cattctggct gagcccgggg acaccattgc gctggtcttc   1140

actgactttc agctagaaga aggatatgat ttcttagaga tcagtggcac ggaagctcca   1200

tccatatggc taactggcat gaacctcccc tctccagtta tcagtagcaa gaattggcta   1260

cgactccatt tcacctctga cagcaaccac cgacgcaaag gatttaacgc tcagttccaa   1320

gtgaaaaagg cgattgagtt gaagtcaaga ggagtcaaga tgctgcccag caaggatgga   1380

agccataaaa actctgtctt gagccaagga ggtgttgcat tggtctctga catgtgtcca   1440

gatcctggga ttccagaaaa tggtagaaga gcaggttccg acttcagtag ggttggtgca   1500

aatgtacagt tttcatgtga ggacaattac gtgctccagg gatctaaaag catcacctgt   1560

cagagagtta cagagacgct cgctgcttgg agtgaccaca ggcccatctg ccgagcgaga   1620

acatgtggat ccaatctgcg tgggcccagc ggcgtcatta cctcccctaa ttatccggtt   1680

cagtatgaag ataatgcaca ctgtgtgtgg gtcatcacca ccaccgaccc ggacaaggtc   1740

atcaagcttg cctttgaaga gtttgagctg gagcgaggct atgacaccct gacggttggt   1800

gatgctggga aggtgggaga caccagatcg gtcttgtacg tgctcacggg atccagtgtt   1860

cctgacctca ttgtgagcat gagcaaccag atgtggctac atctgcagtc ggatgatagc   1920

attggctcac ctgggtttaa agctgtttac caagaaattg aaaagggagg gtgtggggat   1980

cctggaatcc ccgcctatgg gaagcggacg ggcagcagtt tcctccatgg agatacactc   2040

acctttgaat gcccggcggc ctttgagctg gtgggggaga gagttatcac ctgtcagcag   2100

aacaatcagt ggtctggcaa caagcccagc tgtgtatttt catgtttctt caactttacg   2160

gcatcatctg ggattattct gtcaccaaat tatccagagg aatatgggaa caacatgaac   2220

tgtgtctggt tgattatctc ggagccagga agtcgaattc acctaatctt taatgatttt   2280

gatgttgagc ctcagtttga ctttctcgcg gtcaaggatg atggcatttc tgacataact   2340

gtcctgggta ctttttctgg caatgaagtg ccttcccagc tggccagcag tgggcatata   2400

gttcgcttgg aatttcagtc tgaccattcc actactggca gagggttcaa catcacttac   2460

accacatttg gtcagaatga gtgccatgat cctggcattc ctataaacgg acgacgtttt   2520

ggtgacaggt ttctactcgg gagctcggtt tctttccact gtgatgatgg ctttgtcaag   2580

acccagggat ccgagtccat tacctgcata ctgcaagacg ggaacgtggt ctggagctcc   2640

accgtgcccc gctgtgaagc tccatgtggt ggacatctga cagcgtccag cggagtcatt   2700

ttgcctcctg gatggccagg atattataag gattctttac attgtgaatg gataattgaa   2760

gcaaaaccag gccactctat caaaataact tttgacagat ttcagacaga ggtcaattat   2820

gacaccttgg aggtcagaga tgggccagcc agttcgtccc cactgatcgg cgagtaccac   2880

ggcacccagg caccccagtt cctcatcagc accgggaact tcatgtacct gctgttcacc   2940

actgacaaca gccgctccag catcggcttc ctcatccact atgagagtgt gacgcttgag   3000

tcggattcct gcctggaccc gggcatccct gtgaacggcc atcgccacgg tggagacttt   3060

ggcatcaggt ccacagtgac tttcagctgt gacccggggt acacactaag tgacgacgag   3120

cccctcgtct gtgagaggaa ccaccagtgg aaccacgcct tgcccagctg cgacgctcta   3180

tgtggaggct acatccaagg gaagagtgga acagtccttt ctcctgggtt tccagatttt   3240

tatccaaact ctctaaactg cacgtggacc attgaagtgt ctcatgggaa aggagttcaa   3300

atgatctttc acacctttca tcttgagagt tcccacgact atttactgat cacagaggat   3360

ggaagttttt ccgagcccgt tgccaggctc accgggtcgg tgttgcctca tacgatcaag   3420

gcaggcctgt ttggaaactt cactgcccag cttcggttta tatcagactt ctcaatttcg   3480

tacgagggct tcaatatcac attttcagaa tatgacctgg agccatgtga tgatcctgga   3540

gtccctgcct tcagccgaag aattggtttt cactttggtg tgggagactc tctgacgttt   3600

tcctgcttcc tgggatatcg tttagaaggt gccaccaagc ttacctgcct gggtgggggc   3660

cgccgtgtgt ggagtgcacc tctgccaagg tgtgtggccg aatgtggagc aagtgtcaaa   3720

ggaaatgaag gaacattact gtctccaaat tttccatcca attatgataa taaccatgag   3780

tgtatctata aaatagaaac agaagccggc aagggcatcc accttagaac acgaagcttc   3840

cagctgtttg aaggagatac tctaaaggta tatgatggaa aagacagttc ctcacgtcca   3900

ctgggcacgt tcactaaaaa tgaacttctg gggctgatcc taaacagcac atccaatcac   3960

ctgtggctag agttcaacac caatggatct gacaccgacc aaggttttca actcacctat   4020

accagttttg atctggtaaa atgtgaggat ccgggcatcc ctaactacgg ctataggatc   4080

cgtgatgaag gccactttac cgacactgta gttctgtaca gttgcaaccc ggggtacgcc   4140

atgcatggca gcaacaccct gacctgtttg agtggagaca ggagagtgtg ggacaaacca   4200

ctaccttcgt gcatagcgga atgtggtggt cagatccatg cagccacatc aggacgaata   4260

ttgtcccctg gctatccagc tccgtatgac aacaacctcc actgcacctg gattatagag   4320

gcagacccag gaaagaccat tagcctccat ttcattgttt tcgacacgga gatggctcac   4380

gacatcctca aggtctggga cgggccggtg gacagtgaca tcctgctgaa ggagtggagt   4440

ggctccgccc ttccggagga catccacagc accttcaact cactcaccct gcagttcgac   4500

agcgacttct tcatcagcaa gtctggcttc tccatccagt tctccacctc aattgcagcc   4560

acctgtaacg atccaggtat gccccaaaat ggcacccgct atggagacag cagagaggct   4620

ggagacaccg tcacattcca gtgtgaccct ggctatcagc tccaaggaca agccaaaatc   4680

acctgtgtgc agctgaataa ccggttcttt tggcaaccag accctcctac atgcatagct   4740

gcttgtggag ggaatctgac gggcccagca ggtgttattt tgtcacccaa ctacccacag   4800

ccgtatcctc ctgggaagga atgtgactgg agagtaaaag tgaacccgga ctttgtcatc   4860

gccttgatat tcaaaagttt caacatggag cccagctatg acttcctaca catctatgaa   4920

ggggaagatt ccaacagccc cctcattggg agttaccagg gctctcaggc cccagaaaga   4980

atagagagta gcggaaacag cctgtttctg gcatttcgga gtgatgcctc cgtgggcctt   5040

tcagggttcg ccattgaatt taaagagaaa ccacgggaag cttgttttga cccaggaaat   5100

ataatgaatg ggacaagagt tggaacagac ttcaagcttg gctccaccat cacctaccag   5160

tgtgactctg gctataagat tcttgacccc tcatccatca cctgtgtgat tggggctgat   5220

gggaaaccct cctgggacca agtgctgccc tcctgcaatg ctccctgtgg aggccagtac   5280

acgggatcag aaggggtagt tttatcacca aactaccccc ataattacac agctggtcaa   5340

atatgcctct attccatcac ggtaccaaag gaattcgtgg tctttggaca gtttgcctat   5400

ttccagacag ccctgaatga tttggcagaa ttatttgatg gaacccatgc acaggccaga   5460

cttctcagct cactctcggg gtctcactca ggggaaacat tgcccttggc tacgtcaaat   5520

caaattctgc tccgattcag tgcaaagagc ggtgcctctg cccgcggctt ccacttcgtg   5580

tatcaagctg ttcctcgtac cagtgacacc caatgcagct ctgtccccga gcccagatac   5640

ggaaggagaa ttggttctga gttttctgcc ggctccatcg tccgattcga gtgcaacccg   5700

ggatacctgc ttcagggttc cacggcgctc cactgccagt ccgtgcccaa cgccttggca   5760

cagtggaacg acacgatccc cagctgtgtg gtaccctgca gtggcaattt cactcaacga   5820

agaggtacaa tcctgtcccc cggctaccct gagccatacg gaaacaactt gaactgtata   5880

tggaagatca tagttacgga gggctcggga attcagatcc aagtgatcag ttttgccacg   5940

gagcagaact gggactccct tgagatccac gatggtgggg atgtgaccgc acccagactg   6000

ggaagcttct caggcaccac agtaccggca ctgctgaaca gtacttccaa ccaactctac   6060

ctgcatttcc agtctgacat tagtgtggca gctgctggtt tccacctgga atacaaaact   6120

gtaggtcttg ctgcatgcca agaaccagcc ctccccagca acagcatcaa aatcggagat   6180

cggtacatgg tgaacgacgt gctctccttc cagtgcgagc ccgggtacac cctgcagggc   6240

cgttcccaca tttcctgtat gccagggacc gttcgccgtt ggaactatcc gtctcccctg   6300

tgcattgcaa cctgtggagg gacgctgagc accttgggtg gtgtgatcct gagccccggc   6360

ttcccaggtt cttaccccaa caacttagac tgcacctgga ggatctcatt acccatcggc   6420

tatggtgcac atattcagtt tctgaatttt tctaccgaag ctaatcatga cttccttgaa   6480

attcaaaatg gaccttacca caccagcccc atgattggac aatttagcgg cacggatctc   6540

cccgcggccc tgctgagcac aacgcatgaa accctcatcc acttttatag tgaccattcg   6600

caaaaccggc aaggatttaa acttgcttac caagcctatg aattacagaa ctgtccagat   6660

ccacccccat ttcagaatgg gtacatgatc aactcggatt acagcgtggg gcaatcagta   6720

tctttcgagt gttatcctgg gtacattcta ataggccatc ctgtcctcac ttgtcagcat   6780

gggatcaaca gaaactggaa ctaccctttt ccaagatgtg atgccccttg tgggtacaac   6840

gtaacttctc agaacggcac catctactcc cctggctttc ctgatgagta tccgatcctg   6900

aaggactgca tttggctcat cacggtgcct ccagggcacg gagtttacat caacttcacc   6960

ctgttacaga cggaagctgt caacgattac attgctgttt gggacggtcc cgatcagaac   7020

tcaccccagc tgggagtttt cagtggcaac acagccctcg aaacggcgta tagctccacc   7080

aaccaagtcc tgctcaagtt ccacagcgac ttttcaaatg gaggcttctt tgtcctcaat   7140

ttccacgcat ttcagctcaa gaaatgtcaa cctcccccag cggttccaca ggcagaaatg   7200

cttactgagg atgatgattt cgaaatagga gattttgtga agtaccagtg ccaccccggg   7260

tacaccttgg tggggaccga cattctgact tgcaagctca gttcccagtt gcagtttgag   7320

ggttctctcc caacatgtga agcacaatgc ccagcaaatg aagtccggac tggatcatcg   7380

ggagtcattc tcagtccagg gtatccgggt aattatttta actcccagac ttgctcttgg   7440

agtattaaag tggaaccaaa ctacaacatt accatctttg tggacacatt tcaaagtgaa   7500

aagcagtttg atgcactgga agtgtttgat ggttcttctg ggcaaagtcc tctgctagta   7560

gtcttaagtg ggaatcatac tgaacaatca aattttacaa gcaggagtaa tcagttatat   7620

ctccgctggt ccactgacca tgccaccagt aagaaaggat tcaagattcg ctatgcagca   7680

ccttactgca gtttgaccca ccccctgaag aatgggggta ttctaaacag gactgcagga   7740

gcggttggaa gcaaagtgca ttatttttgc aagcctggat accgaatggt cggccacagc   7800

aatgcaacct gtagacgaaa cccacttggc atgtaccagt gggactccct cacgccactc   7860

tgccaggctg tgtcctgtgg aatcccagaa tccccaggaa acggttcatt taccgggaac   7920

gagttcactt tggacagtaa agtggtctat gaatgtcatg agggcttcaa gcttgaatcc   7980

agccagcaag caacagccgt gtgtcaagaa gatgggttgt ggagtaacaa ggggaagccg   8040

cccacgtgta agccggtcgc ttgccccagc attgaagctc agctctcaga acatgtcatc   8100

tggaggctgg tttcaggatc cttgaatgag tacggtgctc aagtattgct gagctgcagt   8160

cctggttact acttagaagg ctggaggctc ctgcggtgcc aggccaatgg gacgtggaac   8220

ataggagatg agaggccaag ctgtcgagtt atctcgtgtg gaagcctttc ctttccccca   8280

aatggcaaca agattggaac gttgacagtt tatggggcca cagctatatt tacgtgcaac   8340

accggctaca cgcttgtggg gtctcatgtc agagagtgct tggcaaatgg gctctggagc   8400

ggcagcgaaa ctcgatgtct ggctggccac tgcggttccc cagacccgat tgtgaacggt   8460

cacattagtg gagatggctt cagttacaga gacacggtgg tttaccagtg caatcctggt   8520

ttccggcttg tgggaacttc cgtgaggata tgcctgcaag accacaagtg gtctggacaa   8580

acgcctgtct gtgtccccat cacatgtggt caccctggaa accctgccca cggattcact   8640

aatggcagtg agttcaacct gaatgatgtc gtgaatttca cctgcaacac gggctatttg   8700

ctgcagggcg tgtctcgagc ccagtgtcgg agcaacggcc agtggagtag ccctctgccc   8760

acgtgtcgag tggtgaactg ttctgatcca ggctttgtgg aaaatgccat tcgtcacggg   8820

caacagaact tccctgagag ttttgagtat ggaatgagta tcctgtacca ttgcaagaag   8880

ggattttact tgctgggatc ttcagccttg acctgtatgg caaatggctt atgggaccga   8940

tccctgccca agtgtttggc tatatcgtgt ggacacccag gggtccctgc caacgccgtc   9000

ctcactggag agctgtttac ctatggcgcc gtcgtgcact actcctgcag agggagcgag   9060

agcctcatag gcaacgacac gagagtgtgc caggaagaca gtcactggag cggggcactg   9120

ccccactgca caggaaataa tcctggattc tgtggtgatc cggggacccc agcacatggg   9180

tctcggcttg gtgatgactt taagacaaag agtcttctcc gcttctcctg tgaaatgggg   9240

caccagctga ggggctcccc tgaacgcacg tgtttgctca atgggtcatg gtcaggactg   9300

cagccggtgt gtgaggccgt gtcctgtggc aaccctggca cacccaccaa cggaatgatt   9360

gtcagtagtg atggcattct gttctccagc tcggtcatct atgcctgctg ggaaggctac   9420

aagacctcag ggctcatgac acggcattgc acagccaatg ggacctggac aggcactgct   9480

cccgactgca caattataag ttgtggggat ccaggcacac tagcaaatgg catccagttt   9540

gggaccgact tcaccttcaa caagactgtg agctatcagt gtaacccagg ctatgtcatg   9600

gaagcagtca catccgccac tattcgctgt accaaagacg gcaggtggaa tccgagcaaa   9660

cctgtctgca aagccgtgct gtgtcctcag ccgccgccgg tgcagaatgg aacagtggag   9720

ggaagtgatt tccgctgggg ctccagcata agttacagct gcatggacgg ttaccagctc   9780

tctcactccg ccatcctctc ctgtgaaggt cgcggggtgt ggaaaggaga gatcccccag   9840

tgtctccctg tgttctgcgg agaccctggc atccccgcag aagggcgact tagtgggaaa   9900

agtttcacct ataagtccga agtcttcttc cagtgcaaat ctccatttat actcgtggga   9960

tcctccagaa gagtctgcca agctgacggc acgtggagcg gcatacaacc cacctgcatt  10020

gatcctgctc ataacacctg cccagaccct ggtacgccac actttggaat acagaatagc  10080

tccagaggct atgaggttgg aagcacggtt tttttcaggt gcagaaaagg ctaccatatt  10140

caaggttcca cgactcgcac ctgccttgcc aatttaacat ggagtgggat acagaccgaa  10200

tgtatacctc atgcctgcag acagccagaa accccggcac acgcggatgt gagagccatc  10260

gatcttccta ctttcggcta caccttagtg tacacctgcc atccaggctt tttcctcgca  10320

gggggatctg agcacagaac atgtaaagca gacatgaaat ggacaggaaa gtcgcctgtg  10380

tgtaaaagta aaggagtgag agaagttaat gaaacagtta ctaaaactcc agttccttca  10440

gatgtctttt tcgtcaattc actgtggaag gggtattatg aatatttagg gaaaagacaa  10500

cccgccactc taactgttga ctggttcaat gcaacaagca gtaaggtgaa tgccaccttc  10560

agcgaagcct cgccagtgga gctgaagttg acaggcattt acaagaagga ggaggcccac  10620

ttactcctga aagcttttca aattaaaggc caggcagata tttttgtaag caagttcgaa  10680

aatgacaact ggggactaga tggttatgtg tcatctggac ttgaaagagg aggatttact  10740

tttcaaggtg acattcatgg aaaagacttt ggaaaattta agctagaaag gcaagatcct  10800

ttaaacccag atcaagactc ttccagtcat taccacggca ccagcagtgg ctctgtggcg  10860

gctgccattc tggttccttt ctttgctcta attttatcag ggtttgcatt ttacctctac  10920

aaacacagaa cgagaccaaa agttcaatac aatggctatg ctgggcatga aaacagcaat  10980

ggacaagcat cgtttgaaaa ccccatgtat gatacaaact taaaacccac agaagccaag  11040

gctgtgaggt ttgacacaac tctgaacaca gtctgtacag tggtatagcc ctcagtgccc  11100

caacaggact gattcatagc catacctctg atggacaagc agtgattcct ttggtgccat  11160

ataccactct cccttccact ctggctttac tgcagcgatc ttcaaccttg tctactggca  11220

taagtgcagc ggggatctct actcaaatgt gtcagggtct tctacggatc aaactacaca  11280

tgcgttttca ttccaaaagt gggttctaaa tgcctggctg catctgtatg aaatcaaggc  11340

acactccagg aagactgcca cgtcgcgcca acacgtcata ctcaatgcct cagactttca  11400

tatttctgtg ttgctgagat gcctttcaat gcaatcgtct gggctcgtgg atatgtccct  11460

caggtgcggt gacagaatgg tggcaccacg atatgtgttc tcttgtgttg tttttccttt  11520

ttaaaccccc atgaacacga atactctgaa aaaaataaaa agctttctgg aagaagacac  11580

ctttctgata gaggctcaca cctacaaatg cttcactctg tccttccgag acctgacaag  11640

ctttgaggac ctcacagctc ccctgtgtgt tcatctctag ggatgtttgc aatttcccag  11700

tcagctgttc tgtcgcagaa tgtttaatgc acaatttttt gcactagtgt gttatgaatg  11760

actaagattc tgataaaaaa aataaattat ttacacaggg tttatacaca ctatccattg  11820

tatataagca ttatttcata ttatcaagct aaacattccc ccatcagctt agttggagtg  11880

ttagggaaaa gtattcctag atatggcaca gattttaaaa ggaaatacag tattgaagag  11940

atttatttta ttattgcttc aattagctcc atttacgtgt tgaattcatt gaagaggtcc  12000

aatgagaaaa aaacagaagc ctccttattt cacacgtttt cctcctttag taccatcctc  12060

atccaattac tgtctctctg atactactta atagcagggg gtttgcagaa atttctgttt  12120

gccatgtaaa actgtgaata gtaatttatt ttagatagtc gatgaacttg tgggttttag  12180

ctcacaatgc agccttccct tttgcagtgt tttttttttg tttttttttt tttttgtctt  12240

ttactgtgcc atcgatcttt gatattgcat tgaaagacaa tataccacag tagcaccttg  12300

aactcagtga aaattgttca ggatcaaaat accaagtgtt cttttagagg gaaggaaaaa  12360

gtacacacac tctcctctca caatgatata ttttatacat tcatttgtta tttgtttcat  12420

gctttatgat tccagatgga aaggtaattt cagtgacttt tcaagtttaa attccattat  12480

aggtaaatga taagttatga tgcaaataaa atctataaga tccccagggc aaataaaaat  12540

caaaacatga agtagaagat gtggccgtga ggtagtttat gtaacaaatt caaagtgaaa  12600

atcatgttta cttttactta tacttatttg ataaaaatat ttttgaaacg atagtactta  12660

ttttattatt tgatatttca gttcctattc aattgtggca gattttctct gtttcacatt  12720

ttagattggc gttggtaata gaaatgtcag aatgttcaaa ttggccttca cgttgtcgga  12780

gtgaacacat tgacacctag ctttaagact gatttatctg ttggtgtact gaaggtttcc  12840

atgtaggact tcaaatgtgg aaaaggaaaa gcagtcagga aaatggggca ttctttggag  12900

agtcacgcgt tttgattcgg acatttccgt agagctcggc tcccagtgtt gtgttcctcg  12960

gtcgaaaggg tctctgctgt ttggggactc actggcctct cctagggact cctttgtctt  13020

gtgaacccca cgctgttgga ttctgtatca ttatgctgaa ttctctgcac agttttccct  13080

ggccaacctg cccacatcct tggagatttg ctttgccagt gggaatcctt acattgctgt  13140

ttcacagtag acgggacgag gtcagcggga gtcgtgctcc taacacacac attgaacgaa  13200

acagaagatg attgaaagtg tgaggaggct cgtgtgcaag ggagaacagg gttactatac  13260

atattagtgt atatatatac atacatatat atatatatat attgtacata tctaagtttg  13320

agtcattcaa actaggtgca aaatgctgac ttcagagtct gaattaacat ctctgttccc  13380

atatccctga cctgctccct ggtcaacgat gctatgaaat cctgaaatga caggacatac  13440

atacatacaa gaaaccacat atcaaattag atatgatttt cctttgtgtg caaagtcaaa  13500

ctgtcctagg gttgccagtt tgaagcatgt tatttaaatg aaaaaaaaaa tcagtgaaat  13560

tctcgtgtga gaattctgcc tagtttcttc ctaaggttgt gtgcagtgtt gaacggcgtc  13620

tccgcaaggt gttggaggat ctcattttag ggcagtcagg agctgtgctt gctgagttag  13680

gtctagaaga ctcttccctg aaggcaacgg gaacacgcgt gagggacgcg accacacact  13740

aacagaggac acgtgcttca gagctgttta aaactgctgc ttgttttaca cacacatctt  13800

gccttttttc aggctagctg caataatttt tttcttctgt aaaatatttt gtaaacaaca  13860

acaaaaagct attataaaaa gggggtaaaa aaaagaacgc tggcattatg atcaggaaaa  13920

cccattgtca tcgccgaccc tccctcccgt cccaccacac gctgctgtca cgacgtaggt  13980

gcgaaagacc tttttgtaca gagatatatt ttttatgaag aatttgtaaa attattaaat  14040

atgctgtaat tttttgatta atgtaggtac attgttaaaa aataaatgtt tttacaatac  14100

agaactgtaa ttttcccaat aatgtaaaat gtaccatctc tagctgattt tcagttccaa  14160

tcctattaca catgtattaa tattaaagtg gcctgttaaa atgaacagta tctttttttt  14220

gtcaaaaaaa ttataaagag ggtgtaatat agcctgtgca atgccaccaa tctttaaagc  14280

aaatcagagt tctaattaaa tatttaattt tagatttcta                        14320


<210>  359
<211>  3565
<212>  PRT
<213>  Homo sapiens

<400>  359


Met Thr Ala Trp Arg Arg Phe Gln Ser Leu Leu Leu Leu Leu Gly Leu 
1               5                   10                  15      


Leu Val Leu Cys Ala Arg Leu Leu Thr Ala Ala Lys Gly Gln Asn Cys 
            20                  25                  30          


Gly Gly Leu Val Gln Gly Pro Asn Gly Thr Ile Glu Ser Pro Gly Phe 
        35                  40                  45              


Pro His Gly Tyr Pro Asn Tyr Ala Asn Cys Thr Trp Ile Ile Ile Thr 
    50                  55                  60                  


Gly Glu Arg Asn Arg Ile Gln Leu Ser Phe His Thr Phe Ala Leu Glu 
65                  70                  75                  80  


Glu Asp Phe Asp Ile Leu Ser Val Tyr Asp Gly Gln Pro Gln Gln Gly 
                85                  90                  95      


Asn Leu Lys Val Arg Leu Ser Gly Phe Gln Leu Pro Ser Ser Ile Val 
            100                 105                 110         


Ser Thr Gly Ser Ile Leu Thr Leu Trp Phe Thr Thr Asp Phe Ala Val 
        115                 120                 125             


Ser Ala Gln Gly Phe Lys Ala Leu Tyr Glu Val Leu Pro Ser His Thr 
    130                 135                 140                 


Cys Gly Asn Pro Gly Glu Ile Leu Lys Gly Val Leu His Gly Thr Arg 
145                 150                 155                 160 


Phe Asn Ile Gly Asp Lys Ile Arg Tyr Ser Cys Leu Pro Gly Tyr Ile 
                165                 170                 175     


Leu Glu Gly His Ala Ile Leu Thr Cys Ile Val Ser Pro Gly Asn Gly 
            180                 185                 190         


Ala Ser Trp Asp Phe Pro Ala Pro Phe Cys Arg Ala Glu Gly Ala Cys 
        195                 200                 205             


Gly Gly Thr Leu Arg Gly Thr Ser Ser Ser Ile Ser Ser Pro His Phe 
    210                 215                 220                 


Pro Ser Glu Tyr Glu Asn Asn Ala Asp Cys Thr Trp Thr Ile Leu Ala 
225                 230                 235                 240 


Glu Pro Gly Asp Thr Ile Ala Leu Val Phe Thr Asp Phe Gln Leu Glu 
                245                 250                 255     


Glu Gly Tyr Asp Phe Leu Glu Ile Ser Gly Thr Glu Ala Pro Ser Ile 
            260                 265                 270         


Trp Leu Thr Gly Met Asn Leu Pro Ser Pro Val Ile Ser Ser Lys Asn 
        275                 280                 285             


Trp Leu Arg Leu His Phe Thr Ser Asp Ser Asn His Arg Arg Lys Gly 
    290                 295                 300                 


Phe Asn Ala Gln Phe Gln Val Lys Lys Ala Ile Glu Leu Lys Ser Arg 
305                 310                 315                 320 


Gly Val Lys Met Leu Pro Ser Lys Asp Gly Ser His Lys Asn Ser Val 
                325                 330                 335     


Leu Ser Gln Gly Gly Val Ala Leu Val Ser Asp Met Cys Pro Asp Pro 
            340                 345                 350         


Gly Ile Pro Glu Asn Gly Arg Arg Ala Gly Ser Asp Phe Ser Arg Val 
        355                 360                 365             


Gly Ala Asn Val Gln Phe Ser Cys Glu Asp Asn Tyr Val Leu Gln Gly 
    370                 375                 380                 


Ser Lys Ser Ile Thr Cys Gln Arg Val Thr Glu Thr Leu Ala Ala Trp 
385                 390                 395                 400 


Ser Asp His Arg Pro Ile Cys Arg Ala Arg Thr Cys Gly Ser Asn Leu 
                405                 410                 415     


Arg Gly Pro Ser Gly Val Ile Thr Ser Pro Asn Tyr Pro Val Gln Tyr 
            420                 425                 430         


Glu Asp Asn Ala His Cys Val Trp Val Ile Thr Thr Thr Asp Pro Asp 
        435                 440                 445             


Lys Val Ile Lys Leu Ala Phe Glu Glu Phe Glu Leu Glu Arg Gly Tyr 
    450                 455                 460                 


Asp Thr Leu Thr Val Gly Asp Ala Gly Lys Val Gly Asp Thr Arg Ser 
465                 470                 475                 480 


Val Leu Tyr Val Leu Thr Gly Ser Ser Val Pro Asp Leu Ile Val Ser 
                485                 490                 495     


Met Ser Asn Gln Met Trp Leu His Leu Gln Ser Asp Asp Ser Ile Gly 
            500                 505                 510         


Ser Pro Gly Phe Lys Ala Val Tyr Gln Glu Ile Glu Lys Gly Gly Cys 
        515                 520                 525             


Gly Asp Pro Gly Ile Pro Ala Tyr Gly Lys Arg Thr Gly Ser Ser Phe 
    530                 535                 540                 


Leu His Gly Asp Thr Leu Thr Phe Glu Cys Pro Ala Ala Phe Glu Leu 
545                 550                 555                 560 


Val Gly Glu Arg Val Ile Thr Cys Gln Gln Asn Asn Gln Trp Ser Gly 
                565                 570                 575     


Asn Lys Pro Ser Cys Val Phe Ser Cys Phe Phe Asn Phe Thr Ala Ser 
            580                 585                 590         


Ser Gly Ile Ile Leu Ser Pro Asn Tyr Pro Glu Glu Tyr Gly Asn Asn 
        595                 600                 605             


Met Asn Cys Val Trp Leu Ile Ile Ser Glu Pro Gly Ser Arg Ile His 
    610                 615                 620                 


Leu Ile Phe Asn Asp Phe Asp Val Glu Pro Gln Phe Asp Phe Leu Ala 
625                 630                 635                 640 


Val Lys Asp Asp Gly Ile Ser Asp Ile Thr Val Leu Gly Thr Phe Ser 
                645                 650                 655     


Gly Asn Glu Val Pro Ser Gln Leu Ala Ser Ser Gly His Ile Val Arg 
            660                 665                 670         


Leu Glu Phe Gln Ser Asp His Ser Thr Thr Gly Arg Gly Phe Asn Ile 
        675                 680                 685             


Thr Tyr Thr Thr Phe Gly Gln Asn Glu Cys His Asp Pro Gly Ile Pro 
    690                 695                 700                 


Ile Asn Gly Arg Arg Phe Gly Asp Arg Phe Leu Leu Gly Ser Ser Val 
705                 710                 715                 720 


Ser Phe His Cys Asp Asp Gly Phe Val Lys Thr Gln Gly Ser Glu Ser 
                725                 730                 735     


Ile Thr Cys Ile Leu Gln Asp Gly Asn Val Val Trp Ser Ser Thr Val 
            740                 745                 750         


Pro Arg Cys Glu Ala Pro Cys Gly Gly His Leu Thr Ala Ser Ser Gly 
        755                 760                 765             


Val Ile Leu Pro Pro Gly Trp Pro Gly Tyr Tyr Lys Asp Ser Leu His 
    770                 775                 780                 


Cys Glu Trp Ile Ile Glu Ala Lys Pro Gly His Ser Ile Lys Ile Thr 
785                 790                 795                 800 


Phe Asp Arg Phe Gln Thr Glu Val Asn Tyr Asp Thr Leu Glu Val Arg 
                805                 810                 815     


Asp Gly Pro Ala Ser Ser Ser Pro Leu Ile Gly Glu Tyr His Gly Thr 
            820                 825                 830         


Gln Ala Pro Gln Phe Leu Ile Ser Thr Gly Asn Phe Met Tyr Leu Leu 
        835                 840                 845             


Phe Thr Thr Asp Asn Ser Arg Ser Ser Ile Gly Phe Leu Ile His Tyr 
    850                 855                 860                 


Glu Ser Val Thr Leu Glu Ser Asp Ser Cys Leu Asp Pro Gly Ile Pro 
865                 870                 875                 880 


Val Asn Gly His Arg His Gly Gly Asp Phe Gly Ile Arg Ser Thr Val 
                885                 890                 895     


Thr Phe Ser Cys Asp Pro Gly Tyr Thr Leu Ser Asp Asp Glu Pro Leu 
            900                 905                 910         


Val Cys Glu Arg Asn His Gln Trp Asn His Ala Leu Pro Ser Cys Asp 
        915                 920                 925             


Ala Leu Cys Gly Gly Tyr Ile Gln Gly Lys Ser Gly Thr Val Leu Ser 
    930                 935                 940                 


Pro Gly Phe Pro Asp Phe Tyr Pro Asn Ser Leu Asn Cys Thr Trp Thr 
945                 950                 955                 960 


Ile Glu Val Ser His Gly Lys Gly Val Gln Met Ile Phe His Thr Phe 
                965                 970                 975     


His Leu Glu Ser Ser His Asp Tyr Leu Leu Ile Thr Glu Asp Gly Ser 
            980                 985                 990         


Phe Ser Glu Pro Val Ala Arg Leu  Thr Gly Ser Val Leu  Pro His Thr 
        995                 1000                 1005             


Ile Lys  Ala Gly Leu Phe Gly  Asn Phe Thr Ala Gln  Leu Arg Phe 
    1010                 1015                 1020             


Ile Ser  Asp Phe Ser Ile Ser  Tyr Glu Gly Phe Asn  Ile Thr Phe 
    1025                 1030                 1035             


Ser Glu  Tyr Asp Leu Glu Pro  Cys Asp Asp Pro Gly  Val Pro Ala 
    1040                 1045                 1050             


Phe Ser  Arg Arg Ile Gly Phe  His Phe Gly Val Gly  Asp Ser Leu 
    1055                 1060                 1065             


Thr Phe  Ser Cys Phe Leu Gly  Tyr Arg Leu Glu Gly  Ala Thr Lys 
    1070                 1075                 1080             


Leu Thr  Cys Leu Gly Gly Gly  Arg Arg Val Trp Ser  Ala Pro Leu 
    1085                 1090                 1095             


Pro Arg  Cys Val Ala Glu Cys  Gly Ala Ser Val Lys  Gly Asn Glu 
    1100                 1105                 1110             


Gly Thr  Leu Leu Ser Pro Asn  Phe Pro Ser Asn Tyr  Asp Asn Asn 
    1115                 1120                 1125             


His Glu  Cys Ile Tyr Lys Ile  Glu Thr Glu Ala Gly  Lys Gly Ile 
    1130                 1135                 1140             


His Leu  Arg Thr Arg Ser Phe  Gln Leu Phe Glu Gly  Asp Thr Leu 
    1145                 1150                 1155             


Lys Val  Tyr Asp Gly Lys Asp  Ser Ser Ser Arg Pro  Leu Gly Thr 
    1160                 1165                 1170             


Phe Thr  Lys Asn Glu Leu Leu  Gly Leu Ile Leu Asn  Ser Thr Ser 
    1175                 1180                 1185             


Asn His  Leu Trp Leu Glu Phe  Asn Thr Asn Gly Ser  Asp Thr Asp 
    1190                 1195                 1200             


Gln Gly  Phe Gln Leu Thr Tyr  Thr Ser Phe Asp Leu  Val Lys Cys 
    1205                 1210                 1215             


Glu Asp  Pro Gly Ile Pro Asn  Tyr Gly Tyr Arg Ile  Arg Asp Glu 
    1220                 1225                 1230             


Gly His  Phe Thr Asp Thr Val  Val Leu Tyr Ser Cys  Asn Pro Gly 
    1235                 1240                 1245             


Tyr Ala  Met His Gly Ser Asn  Thr Leu Thr Cys Leu  Ser Gly Asp 
    1250                 1255                 1260             


Arg Arg  Val Trp Asp Lys Pro  Leu Pro Ser Cys Ile  Ala Glu Cys 
    1265                 1270                 1275             


Gly Gly  Gln Ile His Ala Ala  Thr Ser Gly Arg Ile  Leu Ser Pro 
    1280                 1285                 1290             


Gly Tyr  Pro Ala Pro Tyr Asp  Asn Asn Leu His Cys  Thr Trp Ile 
    1295                 1300                 1305             


Ile Glu  Ala Asp Pro Gly Lys  Thr Ile Ser Leu His  Phe Ile Val 
    1310                 1315                 1320             


Phe Asp  Thr Glu Met Ala His  Asp Ile Leu Lys Val  Trp Asp Gly 
    1325                 1330                 1335             


Pro Val  Asp Ser Asp Ile Leu  Leu Lys Glu Trp Ser  Gly Ser Ala 
    1340                 1345                 1350             


Leu Pro  Glu Asp Ile His Ser  Thr Phe Asn Ser Leu  Thr Leu Gln 
    1355                 1360                 1365             


Phe Asp  Ser Asp Phe Phe Ile  Ser Lys Ser Gly Phe  Ser Ile Gln 
    1370                 1375                 1380             


Phe Ser  Thr Ser Ile Ala Ala  Thr Cys Asn Asp Pro  Gly Met Pro 
    1385                 1390                 1395             


Gln Asn  Gly Thr Arg Tyr Gly  Asp Ser Arg Glu Ala  Gly Asp Thr 
    1400                 1405                 1410             


Val Thr  Phe Gln Cys Asp Pro  Gly Tyr Gln Leu Gln  Gly Gln Ala 
    1415                 1420                 1425             


Lys Ile  Thr Cys Val Gln Leu  Asn Asn Arg Phe Phe  Trp Gln Pro 
    1430                 1435                 1440             


Asp Pro  Pro Thr Cys Ile Ala  Ala Cys Gly Gly Asn  Leu Thr Gly 
    1445                 1450                 1455             


Pro Ala  Gly Val Ile Leu Ser  Pro Asn Tyr Pro Gln  Pro Tyr Pro 
    1460                 1465                 1470             


Pro Gly  Lys Glu Cys Asp Trp  Arg Val Lys Val Asn  Pro Asp Phe 
    1475                 1480                 1485             


Val Ile  Ala Leu Ile Phe Lys  Ser Phe Asn Met Glu  Pro Ser Tyr 
    1490                 1495                 1500             


Asp Phe  Leu His Ile Tyr Glu  Gly Glu Asp Ser Asn  Ser Pro Leu 
    1505                 1510                 1515             


Ile Gly  Ser Tyr Gln Gly Ser  Gln Ala Pro Glu Arg  Ile Glu Ser 
    1520                 1525                 1530             


Ser Gly  Asn Ser Leu Phe Leu  Ala Phe Arg Ser Asp  Ala Ser Val 
    1535                 1540                 1545             


Gly Leu  Ser Gly Phe Ala Ile  Glu Phe Lys Glu Lys  Pro Arg Glu 
    1550                 1555                 1560             


Ala Cys  Phe Asp Pro Gly Asn  Ile Met Asn Gly Thr  Arg Val Gly 
    1565                 1570                 1575             


Thr Asp  Phe Lys Leu Gly Ser  Thr Ile Thr Tyr Gln  Cys Asp Ser 
    1580                 1585                 1590             


Gly Tyr  Lys Ile Leu Asp Pro  Ser Ser Ile Thr Cys  Val Ile Gly 
    1595                 1600                 1605             


Ala Asp  Gly Lys Pro Ser Trp  Asp Gln Val Leu Pro  Ser Cys Asn 
    1610                 1615                 1620             


Ala Pro  Cys Gly Gly Gln Tyr  Thr Gly Ser Glu Gly  Val Val Leu 
    1625                 1630                 1635             


Ser Pro  Asn Tyr Pro His Asn  Tyr Thr Ala Gly Gln  Ile Cys Leu 
    1640                 1645                 1650             


Tyr Ser  Ile Thr Val Pro Lys  Glu Phe Val Val Phe  Gly Gln Phe 
    1655                 1660                 1665             


Ala Tyr  Phe Gln Thr Ala Leu  Asn Asp Leu Ala Glu  Leu Phe Asp 
    1670                 1675                 1680             


Gly Thr  His Ala Gln Ala Arg  Leu Leu Ser Ser Leu  Ser Gly Ser 
    1685                 1690                 1695             


His Ser  Gly Glu Thr Leu Pro  Leu Ala Thr Ser Asn  Gln Ile Leu 
    1700                 1705                 1710             


Leu Arg  Phe Ser Ala Lys Ser  Gly Ala Ser Ala Arg  Gly Phe His 
    1715                 1720                 1725             


Phe Val  Tyr Gln Ala Val Pro  Arg Thr Ser Asp Thr  Gln Cys Ser 
    1730                 1735                 1740             


Ser Val  Pro Glu Pro Arg Tyr  Gly Arg Arg Ile Gly  Ser Glu Phe 
    1745                 1750                 1755             


Ser Ala  Gly Ser Ile Val Arg  Phe Glu Cys Asn Pro  Gly Tyr Leu 
    1760                 1765                 1770             


Leu Gln  Gly Ser Thr Ala Leu  His Cys Gln Ser Val  Pro Asn Ala 
    1775                 1780                 1785             


Leu Ala  Gln Trp Asn Asp Thr  Ile Pro Ser Cys Val  Val Pro Cys 
    1790                 1795                 1800             


Ser Gly  Asn Phe Thr Gln Arg  Arg Gly Thr Ile Leu  Ser Pro Gly 
    1805                 1810                 1815             


Tyr Pro  Glu Pro Tyr Gly Asn  Asn Leu Asn Cys Ile  Trp Lys Ile 
    1820                 1825                 1830             


Ile Val  Thr Glu Gly Ser Gly  Ile Gln Ile Gln Val  Ile Ser Phe 
    1835                 1840                 1845             


Ala Thr  Glu Gln Asn Trp Asp  Ser Leu Glu Ile His  Asp Gly Gly 
    1850                 1855                 1860             


Asp Val  Thr Ala Pro Arg Leu  Gly Ser Phe Ser Gly  Thr Thr Val 
    1865                 1870                 1875             


Pro Ala  Leu Leu Asn Ser Thr  Ser Asn Gln Leu Tyr  Leu His Phe 
    1880                 1885                 1890             


Gln Ser  Asp Ile Ser Val Ala  Ala Ala Gly Phe His  Leu Glu Tyr 
    1895                 1900                 1905             


Lys Thr  Val Gly Leu Ala Ala  Cys Gln Glu Pro Ala  Leu Pro Ser 
    1910                 1915                 1920             


Asn Ser  Ile Lys Ile Gly Asp  Arg Tyr Met Val Asn  Asp Val Leu 
    1925                 1930                 1935             


Ser Phe  Gln Cys Glu Pro Gly  Tyr Thr Leu Gln Gly  Arg Ser His 
    1940                 1945                 1950             


Ile Ser  Cys Met Pro Gly Thr  Val Arg Arg Trp Asn  Tyr Pro Ser 
    1955                 1960                 1965             


Pro Leu  Cys Ile Ala Thr Cys  Gly Gly Thr Leu Ser  Thr Leu Gly 
    1970                 1975                 1980             


Gly Val  Ile Leu Ser Pro Gly  Phe Pro Gly Ser Tyr  Pro Asn Asn 
    1985                 1990                 1995             


Leu Asp  Cys Thr Trp Arg Ile  Ser Leu Pro Ile Gly  Tyr Gly Ala 
    2000                 2005                 2010             


His Ile  Gln Phe Leu Asn Phe  Ser Thr Glu Ala Asn  His Asp Phe 
    2015                 2020                 2025             


Leu Glu  Ile Gln Asn Gly Pro  Tyr His Thr Ser Pro  Met Ile Gly 
    2030                 2035                 2040             


Gln Phe  Ser Gly Thr Asp Leu  Pro Ala Ala Leu Leu  Ser Thr Thr 
    2045                 2050                 2055             


His Glu  Thr Leu Ile His Phe  Tyr Ser Asp His Ser  Gln Asn Arg 
    2060                 2065                 2070             


Gln Gly  Phe Lys Leu Ala Tyr  Gln Ala Tyr Glu Leu  Gln Asn Cys 
    2075                 2080                 2085             


Pro Asp  Pro Pro Pro Phe Gln  Asn Gly Tyr Met Ile  Asn Ser Asp 
    2090                 2095                 2100             


Tyr Ser  Val Gly Gln Ser Val  Ser Phe Glu Cys Tyr  Pro Gly Tyr 
    2105                 2110                 2115             


Ile Leu  Ile Gly His Pro Val  Leu Thr Cys Gln His  Gly Ile Asn 
    2120                 2125                 2130             


Arg Asn  Trp Asn Tyr Pro Phe  Pro Arg Cys Asp Ala  Pro Cys Gly 
    2135                 2140                 2145             


Tyr Asn  Val Thr Ser Gln Asn  Gly Thr Ile Tyr Ser  Pro Gly Phe 
    2150                 2155                 2160             


Pro Asp  Glu Tyr Pro Ile Leu  Lys Asp Cys Ile Trp  Leu Ile Thr 
    2165                 2170                 2175             


Val Pro  Pro Gly His Gly Val  Tyr Ile Asn Phe Thr  Leu Leu Gln 
    2180                 2185                 2190             


Thr Glu  Ala Val Asn Asp Tyr  Ile Ala Val Trp Asp  Gly Pro Asp 
    2195                 2200                 2205             


Gln Asn  Ser Pro Gln Leu Gly  Val Phe Ser Gly Asn  Thr Ala Leu 
    2210                 2215                 2220             


Glu Thr  Ala Tyr Ser Ser Thr  Asn Gln Val Leu Leu  Lys Phe His 
    2225                 2230                 2235             


Ser Asp  Phe Ser Asn Gly Gly  Phe Phe Val Leu Asn  Phe His Ala 
    2240                 2245                 2250             


Phe Gln  Leu Lys Lys Cys Gln  Pro Pro Pro Ala Val  Pro Gln Ala 
    2255                 2260                 2265             


Glu Met  Leu Thr Glu Asp Asp  Asp Phe Glu Ile Gly  Asp Phe Val 
    2270                 2275                 2280             


Lys Tyr  Gln Cys His Pro Gly  Tyr Thr Leu Val Gly  Thr Asp Ile 
    2285                 2290                 2295             


Leu Thr  Cys Lys Leu Ser Ser  Gln Leu Gln Phe Glu  Gly Ser Leu 
    2300                 2305                 2310             


Pro Thr  Cys Glu Ala Gln Cys  Pro Ala Asn Glu Val  Arg Thr Gly 
    2315                 2320                 2325             


Ser Ser  Gly Val Ile Leu Ser  Pro Gly Tyr Pro Gly  Asn Tyr Phe 
    2330                 2335                 2340             


Asn Ser  Gln Thr Cys Ser Trp  Ser Ile Lys Val Glu  Pro Asn Tyr 
    2345                 2350                 2355             


Asn Ile  Thr Ile Phe Val Asp  Thr Phe Gln Ser Glu  Lys Gln Phe 
    2360                 2365                 2370             


Asp Ala  Leu Glu Val Phe Asp  Gly Ser Ser Gly Gln  Ser Pro Leu 
    2375                 2380                 2385             


Leu Val  Val Leu Ser Gly Asn  His Thr Glu Gln Ser  Asn Phe Thr 
    2390                 2395                 2400             


Ser Arg  Ser Asn Gln Leu Tyr  Leu Arg Trp Ser Thr  Asp His Ala 
    2405                 2410                 2415             


Thr Ser  Lys Lys Gly Phe Lys  Ile Arg Tyr Ala Ala  Pro Tyr Cys 
    2420                 2425                 2430             


Ser Leu  Thr His Pro Leu Lys  Asn Gly Gly Ile Leu  Asn Arg Thr 
    2435                 2440                 2445             


Ala Gly  Ala Val Gly Ser Lys  Val His Tyr Phe Cys  Lys Pro Gly 
    2450                 2455                 2460             


Tyr Arg  Met Val Gly His Ser  Asn Ala Thr Cys Arg  Arg Asn Pro 
    2465                 2470                 2475             


Leu Gly  Met Tyr Gln Trp Asp  Ser Leu Thr Pro Leu  Cys Gln Ala 
    2480                 2485                 2490             


Val Ser  Cys Gly Ile Pro Glu  Ser Pro Gly Asn Gly  Ser Phe Thr 
    2495                 2500                 2505             


Gly Asn  Glu Phe Thr Leu Asp  Ser Lys Val Val Tyr  Glu Cys His 
    2510                 2515                 2520             


Glu Gly  Phe Lys Leu Glu Ser  Ser Gln Gln Ala Thr  Ala Val Cys 
    2525                 2530                 2535             


Gln Glu  Asp Gly Leu Trp Ser  Asn Lys Gly Lys Pro  Pro Thr Cys 
    2540                 2545                 2550             


Lys Pro  Val Ala Cys Pro Ser  Ile Glu Ala Gln Leu  Ser Glu His 
    2555                 2560                 2565             


Val Ile  Trp Arg Leu Val Ser  Gly Ser Leu Asn Glu  Tyr Gly Ala 
    2570                 2575                 2580             


Gln Val  Leu Leu Ser Cys Ser  Pro Gly Tyr Tyr Leu  Glu Gly Trp 
    2585                 2590                 2595             


Arg Leu  Leu Arg Cys Gln Ala  Asn Gly Thr Trp Asn  Ile Gly Asp 
    2600                 2605                 2610             


Glu Arg  Pro Ser Cys Arg Val  Ile Ser Cys Gly Ser  Leu Ser Phe 
    2615                 2620                 2625             


Pro Pro  Asn Gly Asn Lys Ile  Gly Thr Leu Thr Val  Tyr Gly Ala 
    2630                 2635                 2640             


Thr Ala  Ile Phe Thr Cys Asn  Thr Gly Tyr Thr Leu  Val Gly Ser 
    2645                 2650                 2655             


His Val  Arg Glu Cys Leu Ala  Asn Gly Leu Trp Ser  Gly Ser Glu 
    2660                 2665                 2670             


Thr Arg  Cys Leu Ala Gly His  Cys Gly Ser Pro Asp  Pro Ile Val 
    2675                 2680                 2685             


Asn Gly  His Ile Ser Gly Asp  Gly Phe Ser Tyr Arg  Asp Thr Val 
    2690                 2695                 2700             


Val Tyr  Gln Cys Asn Pro Gly  Phe Arg Leu Val Gly  Thr Ser Val 
    2705                 2710                 2715             


Arg Ile  Cys Leu Gln Asp His  Lys Trp Ser Gly Gln  Thr Pro Val 
    2720                 2725                 2730             


Cys Val  Pro Ile Thr Cys Gly  His Pro Gly Asn Pro  Ala His Gly 
    2735                 2740                 2745             


Phe Thr  Asn Gly Ser Glu Phe  Asn Leu Asn Asp Val  Val Asn Phe 
    2750                 2755                 2760             


Thr Cys  Asn Thr Gly Tyr Leu  Leu Gln Gly Val Ser  Arg Ala Gln 
    2765                 2770                 2775             


Cys Arg  Ser Asn Gly Gln Trp  Ser Ser Pro Leu Pro  Thr Cys Arg 
    2780                 2785                 2790             


Val Val  Asn Cys Ser Asp Pro  Gly Phe Val Glu Asn  Ala Ile Arg 
    2795                 2800                 2805             


His Gly  Gln Gln Asn Phe Pro  Glu Ser Phe Glu Tyr  Gly Met Ser 
    2810                 2815                 2820             


Ile Leu  Tyr His Cys Lys Lys  Gly Phe Tyr Leu Leu  Gly Ser Ser 
    2825                 2830                 2835             


Ala Leu  Thr Cys Met Ala Asn  Gly Leu Trp Asp Arg  Ser Leu Pro 
    2840                 2845                 2850             


Lys Cys  Leu Ala Ile Ser Cys  Gly His Pro Gly Val  Pro Ala Asn 
    2855                 2860                 2865             


Ala Val  Leu Thr Gly Glu Leu  Phe Thr Tyr Gly Ala  Val Val His 
    2870                 2875                 2880             


Tyr Ser  Cys Arg Gly Ser Glu  Ser Leu Ile Gly Asn  Asp Thr Arg 
    2885                 2890                 2895             


Val Cys  Gln Glu Asp Ser His  Trp Ser Gly Ala Leu  Pro His Cys 
    2900                 2905                 2910             


Thr Gly  Asn Asn Pro Gly Phe  Cys Gly Asp Pro Gly  Thr Pro Ala 
    2915                 2920                 2925             


His Gly  Ser Arg Leu Gly Asp  Asp Phe Lys Thr Lys  Ser Leu Leu 
    2930                 2935                 2940             


Arg Phe  Ser Cys Glu Met Gly  His Gln Leu Arg Gly  Ser Pro Glu 
    2945                 2950                 2955             


Arg Thr  Cys Leu Leu Asn Gly  Ser Trp Ser Gly Leu  Gln Pro Val 
    2960                 2965                 2970             


Cys Glu  Ala Val Ser Cys Gly  Asn Pro Gly Thr Pro  Thr Asn Gly 
    2975                 2980                 2985             


Met Ile  Val Ser Ser Asp Gly  Ile Leu Phe Ser Ser  Ser Val Ile 
    2990                 2995                 3000             


Tyr Ala  Cys Trp Glu Gly Tyr  Lys Thr Ser Gly Leu  Met Thr Arg 
    3005                 3010                 3015             


His Cys  Thr Ala Asn Gly Thr  Trp Thr Gly Thr Ala  Pro Asp Cys 
    3020                 3025                 3030             


Thr Ile  Ile Ser Cys Gly Asp  Pro Gly Thr Leu Ala  Asn Gly Ile 
    3035                 3040                 3045             


Gln Phe  Gly Thr Asp Phe Thr  Phe Asn Lys Thr Val  Ser Tyr Gln 
    3050                 3055                 3060             


Cys Asn  Pro Gly Tyr Val Met  Glu Ala Val Thr Ser  Ala Thr Ile 
    3065                 3070                 3075             


Arg Cys  Thr Lys Asp Gly Arg  Trp Asn Pro Ser Lys  Pro Val Cys 
    3080                 3085                 3090             


Lys Ala  Val Leu Cys Pro Gln  Pro Pro Pro Val Gln  Asn Gly Thr 
    3095                 3100                 3105             


Val Glu  Gly Ser Asp Phe Arg  Trp Gly Ser Ser Ile  Ser Tyr Ser 
    3110                 3115                 3120             


Cys Met  Asp Gly Tyr Gln Leu  Ser His Ser Ala Ile  Leu Ser Cys 
    3125                 3130                 3135             


Glu Gly  Arg Gly Val Trp Lys  Gly Glu Ile Pro Gln  Cys Leu Pro 
    3140                 3145                 3150             


Val Phe  Cys Gly Asp Pro Gly  Ile Pro Ala Glu Gly  Arg Leu Ser 
    3155                 3160                 3165             


Gly Lys  Ser Phe Thr Tyr Lys  Ser Glu Val Phe Phe  Gln Cys Lys 
    3170                 3175                 3180             


Ser Pro  Phe Ile Leu Val Gly  Ser Ser Arg Arg Val  Cys Gln Ala 
    3185                 3190                 3195             


Asp Gly  Thr Trp Ser Gly Ile  Gln Pro Thr Cys Ile  Asp Pro Ala 
    3200                 3205                 3210             


His Asn  Thr Cys Pro Asp Pro  Gly Thr Pro His Phe  Gly Ile Gln 
    3215                 3220                 3225             


Asn Ser  Ser Arg Gly Tyr Glu  Val Gly Ser Thr Val  Phe Phe Arg 
    3230                 3235                 3240             


Cys Arg  Lys Gly Tyr His Ile  Gln Gly Ser Thr Thr  Arg Thr Cys 
    3245                 3250                 3255             


Leu Ala  Asn Leu Thr Trp Ser  Gly Ile Gln Thr Glu  Cys Ile Pro 
    3260                 3265                 3270             


His Ala  Cys Arg Gln Pro Glu  Thr Pro Ala His Ala  Asp Val Arg 
    3275                 3280                 3285             


Ala Ile  Asp Leu Pro Thr Phe  Gly Tyr Thr Leu Val  Tyr Thr Cys 
    3290                 3295                 3300             


His Pro  Gly Phe Phe Leu Ala  Gly Gly Ser Glu His  Arg Thr Cys 
    3305                 3310                 3315             


Lys Ala  Asp Met Lys Trp Thr  Gly Lys Ser Pro Val  Cys Lys Ser 
    3320                 3325                 3330             


Lys Gly  Val Arg Glu Val Asn  Glu Thr Val Thr Lys  Thr Pro Val 
    3335                 3340                 3345             


Pro Ser  Asp Val Phe Phe Val  Asn Ser Leu Trp Lys  Gly Tyr Tyr 
    3350                 3355                 3360             


Glu Tyr  Leu Gly Lys Arg Gln  Pro Ala Thr Leu Thr  Val Asp Trp 
    3365                 3370                 3375             


Phe Asn  Ala Thr Ser Ser Lys  Val Asn Ala Thr Phe  Ser Glu Ala 
    3380                 3385                 3390             


Ser Pro  Val Glu Leu Lys Leu  Thr Gly Ile Tyr Lys  Lys Glu Glu 
    3395                 3400                 3405             


Ala His  Leu Leu Leu Lys Ala  Phe Gln Ile Lys Gly  Gln Ala Asp 
    3410                 3415                 3420             


Ile Phe  Val Ser Lys Phe Glu  Asn Asp Asn Trp Gly  Leu Asp Gly 
    3425                 3430                 3435             


Tyr Val  Ser Ser Gly Leu Glu  Arg Gly Gly Phe Thr  Phe Gln Gly 
    3440                 3445                 3450             


Asp Ile  His Gly Lys Asp Phe  Gly Lys Phe Lys Leu  Glu Arg Gln 
    3455                 3460                 3465             


Asp Pro  Leu Asn Pro Asp Gln  Asp Ser Ser Ser His  Tyr His Gly 
    3470                 3475                 3480             


Thr Ser  Ser Gly Ser Val Ala  Ala Ala Ile Leu Val  Pro Phe Phe 
    3485                 3490                 3495             


Ala Leu  Ile Leu Ser Gly Phe  Ala Phe Tyr Leu Tyr  Lys His Arg 
    3500                 3505                 3510             


Thr Arg  Pro Lys Val Gln Tyr  Asn Gly Tyr Ala Gly  His Glu Asn 
    3515                 3520                 3525             


Ser Asn  Gly Gln Ala Ser Phe  Glu Asn Pro Met Tyr  Asp Thr Asn 
    3530                 3535                 3540             


Leu Lys  Pro Thr Glu Ala Lys  Ala Val Arg Phe Asp  Thr Thr Leu 
    3545                 3550                 3555             


Asn Thr  Val Cys Thr Val Val  
    3560                 3565 

<210>  360
<211>  1502
<212>  DNA
<213>  Homo sapiens

<400>  360
gcggccgcgt cgacgtgaca gccggtacgc ccgggtttgg gcaacctcga ttacgggcgg     60

cctccaggcc cgccagcagc gccccgcgcc gcccgcccgc gcccctgccg ccccccggtt    120

ccggccgcgg accccactct ctgccgttcc ggctgcggct ccgctgccgg tagcgccgtc    180

ccccgggacc acccttcggc tggcgccctc ccatgctctc ggccacccgg agggcttgcc    240

agctcctcct cctccacagc ctctttcccg tcccgaggat gggcaactcg gcctcgaaca    300

tcgtcagccc ccaggaggcc ttgccgggcc ggaaggaaca gacccctgta gcggccaaac    360

atcatgtcaa tggcaacaga acagtcgaac ctttcccaga gggaacacag atggctgtat    420

ttggaatggg atgtttctgg ggagctgaaa ggaaattctg ggtcttgaaa ggagtgtatt    480

caactcaagt tggttttgca ggaggctata cttcaaatcc tacttataaa gaagtctgct    540

cagaaaaaac tggccatgca gaagtcgtcc gagtggtgta ccagccagaa cacatgagtt    600

ttgaggaact gctcaaggtc ttctgggaga atcacgaccc gacccaaggt atgcgccagg    660

ggaacgacca tggcactcag taccgctcgg ccatctaccc gacctctgcc aagcaaatgg    720

aggcagccct gagctccaaa gagaactacc aaaaggttct ttcagagcac ggcttcggcc    780

ccatcactac cgacatccgg gagggacaga ctttctacta tgcggaagac taccaccagc    840

agtacctgag caagaacccc aatggctact gcggccttgg gggcaccggc gtgtcctgcc    900

cagtgggtat taaaaaataa ttgctcccca catggtgggc ctttgaggtt ccagtaaaaa    960

tgctttcaac aaattgggca atgcttgtgt gattcacaat cgtggcattt aaagtgcaca   1020

aagtacaaag gaatttatac agattgggtt taccgaagta taatctatag gaggcgcgat   1080

ggcaagttga taaaatgtga cttatctcct aataagttat ggtgggagtg gagctgtgcg   1140

gtttcctgtg tcttctgggg tctgagtgaa gatagcaggg atgctgtgtt cacccttctt   1200

ggtagaagct aaggtgtgag ctgggaggtt gctggacagg atgggggacc ccagaagtcc   1260

tttatctgtg ctctctgccc gccagtgcct tacaatttgc aaacgtgtat agcctcagtg   1320

actcattcgc tgaaatcctt cgctttacca aatctagaca tacataaggg ctttctctcc   1380

cttttcagcc ctctctgtgc agagaaaaga tgtgagtccg cttgatgaat tctaatgctt   1440

tgcttagagc tatgagaaat gtttgtttta ataaaaacct acagtccaat aaaaaaaaaa   1500

aa                                                                  1502


<210>  361
<211>  235
<212>  PRT
<213>  Homo sapiens

<400>  361


Met Leu Ser Ala Thr Arg Arg Ala Cys Gln Leu Leu Leu Leu His Ser 
1               5                   10                  15      


Leu Phe Pro Val Pro Arg Met Gly Asn Ser Ala Ser Asn Ile Val Ser 
            20                  25                  30          


Pro Gln Glu Ala Leu Pro Gly Arg Lys Glu Gln Thr Pro Val Ala Ala 
        35                  40                  45              


Lys His His Val Asn Gly Asn Arg Thr Val Glu Pro Phe Pro Glu Gly 
    50                  55                  60                  


Thr Gln Met Ala Val Phe Gly Met Gly Cys Phe Trp Gly Ala Glu Arg 
65                  70                  75                  80  


Lys Phe Trp Val Leu Lys Gly Val Tyr Ser Thr Gln Val Gly Phe Ala 
                85                  90                  95      


Gly Gly Tyr Thr Ser Asn Pro Thr Tyr Lys Glu Val Cys Ser Glu Lys 
            100                 105                 110         


Thr Gly His Ala Glu Val Val Arg Val Val Tyr Gln Pro Glu His Met 
        115                 120                 125             


Ser Phe Glu Glu Leu Leu Lys Val Phe Trp Glu Asn His Asp Pro Thr 
    130                 135                 140                 


Gln Gly Met Arg Gln Gly Asn Asp His Gly Thr Gln Tyr Arg Ser Ala 
145                 150                 155                 160 


Ile Tyr Pro Thr Ser Ala Lys Gln Met Glu Ala Ala Leu Ser Ser Lys 
                165                 170                 175     


Glu Asn Tyr Gln Lys Val Leu Ser Glu His Gly Phe Gly Pro Ile Thr 
            180                 185                 190         


Thr Asp Ile Arg Glu Gly Gln Thr Phe Tyr Tyr Ala Glu Asp Tyr His 
        195                 200                 205             


Gln Gln Tyr Leu Ser Lys Asn Pro Asn Gly Tyr Cys Gly Leu Gly Gly 
    210                 215                 220                 


Thr Gly Val Ser Cys Pro Val Gly Ile Lys Lys 
225                 230                 235 

<210>  362
<211>  7656
<212>  DNA
<213>  Homo sapiens

<400>  362
ctccctccct cttccccctt cccctctccc tgcagccgcg tccacactgc gccgcccggg     60

cagcccagag cgcggcgcgc acgggcaccg gcggcgagtg ccgcggccac tgcccctccc    120

gggaccccct gtacgccgtc cgcgccgtcc agggtcacac cggcgacgga acccgccggc    180

agcaattagc cagcatcccg gggtcggccc ccagaagcat tccccggccc aggacgagga    240

tgaacaggac aggcgaggca caaagtcgca actgaacttt ttagaaacat tatttgtgtg    300

tgtatgtgtg tagcagggga gaatgagctg atgccgaggg tccagccacc ccgcctctgc    360

ctcctcctcc ccctgccgcc gctgccctcg cagacgcgcg cgcacacacg gcacttgggc    420

cgggtttccg cgctccgtcc ccccgtttgg atgggggttt tcatttccga aggaggcaca    480

gcccgcggag cgctctgaag ggctggagcc ccaagttact cctcgccagc gccggccgcc    540

cgctgtcact cgcgctggcc ggccggggga agggacccgc acgccgggct ttgttgtgga    600

aatcccggtt acctggctta taacccacac catggataac ttattggact ttgcctgaaa    660

ggagtcatta gtgacattgg atatttgacc gtcttggcca caggtttttc agaatgaatg    720

gaagatcatg cagcatgagt ctccaccgga catcgggaac cccacagggg cctaggatgg    780

tcagtggtca tcacattcct gccatccgag cccactccgg gactcctggc ccctcgccct    840

gtggcagcac atcgagtccc actatggcaa gccttgctaa caacctccat ctcaagatgc    900

cctcaggagg agggatggct cctcagaaca acgtggctga gagccgcatc catctgcctg    960

ccttaagccc caggagacaa atgctcacca atgggaagcc gcgattccag gtcacccagg   1020

ctggaggcat gtcagggtca catactttaa agccaaagca gcaggagttt ggaagccctt   1080

ttcctccaaa tcctgggaaa ggggctcttg gctttgggcc tcagtgcaag tccattggaa   1140

aaggcagctg caacaatcta gtggtcacca gcagtcccat gatggttcag cgactgggac   1200

tcatttcacc tccagcaagc caggtctcta cagcatgcaa ccagatcagt cctagcttac   1260

agagggcaat gaatgcagcc aacctgaata tacctccttc agataccagg tcccttattt   1320

cgcgtgagtc tttggcgtcc acgaccttga gtctgacgga aagtcagtcg gcctcaagca   1380

tgaagcagga gtggtcccag ggctacaggg ccctcccttc gctctccaac cacggctctc   1440

agaatggcct tgatctaggg gatctcctta gccttcctcc cgggacatcc atgtccagca   1500

atagtgtctc taactcatta ccatcctacc tttttggcac ggaaagtagc cactctcctt   1560

accctagtcc tcggcactca tccaccaggt cccactcggc ccgctccaag aagagagcgc   1620

tgtccttgtc cccgctgtcc gatggcatcg ggatagattt caataccatc atccgcacgt   1680

cgcccacgtc cttggtggcc tacatcaacg ggtcgagggc ttcgccggcc aacctgtccc   1740

cgcagccgga ggtctacggg catttcctgg gcgtgcgcgg cagctgcatt ccccagccgc   1800

gcccggtgcc cggcagccag aagggcgtgc tggtggcccc tggaggcctg gcgctgccgg   1860

cctacggcga ggacggggcc ctggagcacg agcgcatgca acagctggag cacggcggcc   1920

tgcagccagg cctggtcaac cacatggtgg tgcagcatgg cctgccgggc cccgacagcc   1980

agtcggccgg cctgttcaag accgaacgcc tggaggagtt cccgggcagc accgtagacc   2040

taccccccgc gcctccgctc cctcctctgc cgccgccccc aggcccccca cccccttacc   2100

atgcccatgc gcaccttcac cacccggagc tcgggcccca cgcccagcag ctggccttgc   2160

cccaggccac cctggacgac gacggggaga tggacggcat cgggggcaag cattgctgcc   2220

gctggatcga ctgcagcgcc ctgtacgacc agcaggagga gctcgtgcgg cacatcgaga   2280

aggtccacat cgaccagcgc aaaggggagg acttcacttg cttctgggcc ggttgccctc   2340

gaagatacaa gcccttcaac gcccgctata aactgctgat ccacatgaga gtccactctg   2400

gggagaagcc caacaagtgt acgtttgaag gttgcgagaa ggccttttca aggcttgaaa   2460

atctcaagat ccacttgcgg agccacacag gcgagaagcc gtatttgtgc cagcatccgg   2520

gttgtcagaa ggccttcagt aactccagtg accgcgccaa acaccagcgg acgcatctgg   2580

acaccaaacc ttatgcttgt caaattccag gatgtaccaa acgctacaca gacccaagtt   2640

ccctaagaaa gcatgtgaag gcacattctt ccaaagagca acaagcaagg aaaaagttgc   2700

ggtccagcac agagctccat ccagacctgc tcacagattg cctcaccgtg cagtccctgc   2760

agccggccac ttcccctaga gatgctgctg ctgaagggac cgtgggacgc tcccctggac   2820

ccgggcctga cctctattca gctcccattt tctccagcaa ttattcaagc cgaagtggaa   2880

cagctgctgg ggccgtacca cccccacatc ctgtcagtca cccttctcca ggacataatg   2940

tacaggggag ccctcacaac ccctcctccc agttacctcc actcacagct gtggacgcag   3000

gagctgagag gtttgcacct tctgctccat ctcctcacca catcagcccc cggagagttc   3060

cagctccttc ttcaatactg caaagaacac agcctcccta tacccagcag ccatcaggtt   3120

cacacctgaa gtcctatcag ccagaaacaa actcttcttt tcaaccaaat ggtatccatg   3180

tccatggatt ttatgggcag ctgcagaagt tctgtccccc acactacccc gattcccaga   3240

gaattgtgcc gcctgtcagc tcctgcagtg tggtgccttc gtttgaggac tgcctagtcc   3300

ctacatccat gggccaggcc agttttgatg ttttccacag agccttctcg actcactcgg   3360

gcattacagt gtatgattta ccttcaagtt cctcgagcct ctttggggag tctctccgca   3420

gcggggctga agatgctacc ttcttgcaga tcagcaccgt ggaccgctgt cctagccagc   3480

tctcctctgt ctacaccgaa ggctaaaagc tctcttggcc actcctgcac acccaggacc   3540

ttgatgttgc ttgccacctt ttgttttcgt actctcacag actgcttgag gaaggatgtc   3600

agcccaatca gcgggccctg cagagttact gatgttcttt cagaaggcag gactgaatgg   3660

cagagctagc tttgcaggaa tcattacagt tgctcctttt tctctctggt tttcctggac   3720

tatgtgacca ggaggactgt cttttcaaag ggaatttaga gcctcactct cctggatacc   3780

tgttacttcc tggctgtcaa cccttaaagg accccagtga aatgatgtgc atatgaaaat   3840

gtagtttggg gatgactcta cctgaaaact ccaaacaggg aaaaagacct caattacgag   3900

aggcatagtg acctgcctca cctaatcctc acccttgctg ctcctgatgc aaagccaggc   3960

acaacaaggg aaatccatgt ccaaagcata gtgtggtctc aactcttaga aactccctgg   4020

gtttcccttt tctcttagcc acatgctaac cagttgcttc tcagtgtttc tcttcaatag   4080

aaaaataagg ttttatatgc cagcagccta tccttgtttt tgcattttaa agacttagtt   4140

atttatacgt attttaaaat gaaaaaaaaa tgtaaaggtc tgtgctttgg atggaaatca   4200

ttattattgt aatcacccca gctatagaca ttttgcacag ctgtggttct gcctggcccc   4260

acctctagca tgttagtttt gcagttagca aaggttacct gagggaaatg gagtgggcac   4320

ctcccgcacc aacagtcctg tagctggaac cttcctgagt tgactgttta gtaactccac   4380

ctcaaagact gtgttcaaag aaaaatgttg tttgactggt ttacccattg cctccactct   4440

ggtgctgcac ccagagaagt gccagatgtg agaactggga cagactgagt catgtgccag   4500

cttcccttgg aaaaccaaac ctagtgatac ttgacttcca gtgctcagat tttactaacg   4560

tttttcagga tatccactca tctgtctgtc tcttccctac acttctctcc accctctttt   4620

tgcatccctc ttaccctctt cctgactgtg gttcatatat ccccaccagc cgccattgtc   4680

tgatcatctt gggaaggtag aggtgacagt tctcgaaaag tctacagaaa gaggcaattc   4740

tttttctgag ttccagtttg aaggcctgga attttcacat agcacttggt cgaaaatatc   4800

aagcctaaat aggaagtcat tttctgtgac acctctacat agctattaca gatcctaagt   4860

cctagggcat cagctataaa aattggccag tcccaaagac acagtaagtt ctaacattct   4920

ggtactatca tatttcaagt attttttctc actttttaaa aatgtttttc tgaacaaaag   4980

tgaaacaatg ccatttatca aactgagatc attacaatct tcaacaagac aactaaaaca   5040

gcttgatgtt agatgggatt ctgtgacagt ttgtatactg acaggtcctt ccagtctccc   5100

tccacagtcc cacaagcgga agtattctac ctgattccag agttcattcc aacatgcagt   5160

agaatgaggt gaatgaagaa ccaagtgtgg gttttgtttt cacagtgcac ttggtcaatc   5220

tagtttctct gagtagtggg ctgtattcta agaaaagctt tcacgtagac gtcaaagtct   5280

gcaaaagaga tgagttagcc actttaaaaa acctgctctg ctttacaaaa gatgcacacc   5340

aggcttcctt tacaagtgaa ctccaaggct gcttgtaaag taccaccctt cctgcagact   5400

ttgtgggtcg tgtcacttgg cctaaacaag tggcctaaca tatgcatgct cacagctagt   5460

agcatccctc atgcgtcctt tgtcatactc tggaaagaaa aaaactctgc tatcttcaga   5520

gaaaccatct attcatactt aaatatggaa gcctttacaa ggaactcaaa atacatttca   5580

tttcatttgt acaatgagaa aaaagatgaa aaggcaaggt tgttattgca gttgacattg   5640

tcagccctgc cttttggctt tatgtaattt aaaatagaaa gggggaagga ggacaagaca   5700

gaagctcaac tttagaaacc atggacatca cctccctctt tgagaggagc tgcttgtgaa   5760

ccaggctcca gtcttcctgt ggcctctcac agtaaccctg cccctttctt acctcacagg   5820

ggcaagaggg actctaaaga gggcgtaagc aatagaggca cctgcagccc tccttcctca   5880

gcaggaaatc aatgtggagc cccagaggga cattttatct cagagagagc atgctggcca   5940

caggacccag tgcagccctg cttcccgcac cgtgggtctt tcctgatagc tgcaggcttg   6000

agattgcagc ctcaggatag gacacgttca gatgccttcc agactacaca cactatgctt   6060

agattcgaga gtctttcctg accttaaaat ttgtcccttg cttactttca cactgcagaa   6120

gatttatata tatattcatc attatttttg cagcagtaca agtggaaact tcaaaaaaat   6180

cattcccttt catgtcctgg tctttttaag tcttgatatg taaccatttt cataaatgtc   6240

caaacagaga ttgtcattcc ccttaaaaac agaaacaaaa cacaaaacta gtgcttgtga   6300

aaacacacag cgcaaagaca attatcctat tgcattaaaa aaaaaatcag tctgcctaga   6360

gacatttcat tggctgcatt gtcttaattc cctaacgaaa ctgcatcaaa atgtcagttg   6420

taatttagcc tctgatcagc tgttaaatat tatttaaata tttacaggtc ctgtggggta   6480

tctcccatta cccatgtcgc cctcaaatta cataagcgat cataaaataa gaagaaaaaa   6540

aaaggtcttt agtagatcac agcagagtta ccactgataa gagtgttggc tttgttcagt   6600

tgtttctaaa ttaccagccg tcaagcacag tagcccctaa aaccaatttt gagcaaggat   6660

aaattcaact ccctcatctg agaaccttga ctttccagtt gccttgaagt attgggaata   6720

gtaactgtac attttcaatt taattatttg gtattttatt tgactgtctt ggccatgtca   6780

ttttatggaa gcatttttaa atagcacttt ttgttagtgg tgtggaattt ctgcggttat   6840

tatttttttt tttttttgca acagatgaag caaaaaaaaa aaagcactca ttggagaaat   6900

agtgagtgta aaaagagatt tattttgtac agacagcaaa gtatcctgtg taatgttgct   6960

gacataaagc actttggggg aaaaaagtgg aaatctgttt tccataaatc acacagactc   7020

ttgtacatag ttatatacac tcacgtagag aaatgaactg catatatcat actggatatg   7080

gggccgattt tactctagag gcacatctgg tgcttattgt cataaatctt ttaaagaatt   7140

aggtacactt ttttctatta atatgtatag ttttgtgatt tgtcacagtt atgtttcata   7200

taatcataag ttattttgtc ttgttcatga agtccttttt ttatgtcaaa agtaaaatga   7260

agggattgtg cacttggtac agaataaaac tggaaataga gaagacgccc tcctgcctaa   7320

aatcctcctt cagcctgtcg gtttaaaaca caatggcaac catcattgtt tgtttgtttg   7380

tttttttgtt ttgttttacc atcagcctct tacatactgg gaatggtaat tataattaaa   7440

ggcagatgat gcgggaggga atgttcaagt ccagctttaa aatgctgcat tgctttgggc   7500

cagagctgta gcctggattt aattatagat atgaggagga aatggcagta aaaatgaatg   7560

tctccctgag tcctttacat gttgggagtg tccataaata aaacatgaag ttttatttca   7620

tcagatttaa ttaaagcttt tatacatgtt aaaaaa                             7656


<210>  363
<211>  930
<212>  PRT
<213>  Homo sapiens

<400>  363


Met Asn Gly Arg Ser Cys Ser Met Ser Leu His Arg Thr Ser Gly Thr 
1               5                   10                  15      


Pro Gln Gly Pro Arg Met Val Ser Gly His His Ile Pro Ala Ile Arg 
            20                  25                  30          


Ala His Ser Gly Thr Pro Gly Pro Ser Pro Cys Gly Ser Thr Ser Ser 
        35                  40                  45              


Pro Thr Met Ala Ser Leu Ala Asn Asn Leu His Leu Lys Met Pro Ser 
    50                  55                  60                  


Gly Gly Gly Met Ala Pro Gln Asn Asn Val Ala Glu Ser Arg Ile His 
65                  70                  75                  80  


Leu Pro Ala Leu Ser Pro Arg Arg Gln Met Leu Thr Asn Gly Lys Pro 
                85                  90                  95      


Arg Phe Gln Val Thr Gln Ala Gly Gly Met Ser Gly Ser His Thr Leu 
            100                 105                 110         


Lys Pro Lys Gln Gln Glu Phe Gly Ser Pro Phe Pro Pro Asn Pro Gly 
        115                 120                 125             


Lys Gly Ala Leu Gly Phe Gly Pro Gln Cys Lys Ser Ile Gly Lys Gly 
    130                 135                 140                 


Ser Cys Asn Asn Leu Val Val Thr Ser Ser Pro Met Met Val Gln Arg 
145                 150                 155                 160 


Leu Gly Leu Ile Ser Pro Pro Ala Ser Gln Val Ser Thr Ala Cys Asn 
                165                 170                 175     


Gln Ile Ser Pro Ser Leu Gln Arg Ala Met Asn Ala Ala Asn Leu Asn 
            180                 185                 190         


Ile Pro Pro Ser Asp Thr Arg Ser Leu Ile Ser Arg Glu Ser Leu Ala 
        195                 200                 205             


Ser Thr Thr Leu Ser Leu Thr Glu Ser Gln Ser Ala Ser Ser Met Lys 
    210                 215                 220                 


Gln Glu Trp Ser Gln Gly Tyr Arg Ala Leu Pro Ser Leu Ser Asn His 
225                 230                 235                 240 


Gly Ser Gln Asn Gly Leu Asp Leu Gly Asp Leu Leu Ser Leu Pro Pro 
                245                 250                 255     


Gly Thr Ser Met Ser Ser Asn Ser Val Ser Asn Ser Leu Pro Ser Tyr 
            260                 265                 270         


Leu Phe Gly Thr Glu Ser Ser His Ser Pro Tyr Pro Ser Pro Arg His 
        275                 280                 285             


Ser Ser Thr Arg Ser His Ser Ala Arg Ser Lys Lys Arg Ala Leu Ser 
    290                 295                 300                 


Leu Ser Pro Leu Ser Asp Gly Ile Gly Ile Asp Phe Asn Thr Ile Ile 
305                 310                 315                 320 


Arg Thr Ser Pro Thr Ser Leu Val Ala Tyr Ile Asn Gly Ser Arg Ala 
                325                 330                 335     


Ser Pro Ala Asn Leu Ser Pro Gln Pro Glu Val Tyr Gly His Phe Leu 
            340                 345                 350         


Gly Val Arg Gly Ser Cys Ile Pro Gln Pro Arg Pro Val Pro Gly Ser 
        355                 360                 365             


Gln Lys Gly Val Leu Val Ala Pro Gly Gly Leu Ala Leu Pro Ala Tyr 
    370                 375                 380                 


Gly Glu Asp Gly Ala Leu Glu His Glu Arg Met Gln Gln Leu Glu His 
385                 390                 395                 400 


Gly Gly Leu Gln Pro Gly Leu Val Asn His Met Val Val Gln His Gly 
                405                 410                 415     


Leu Pro Gly Pro Asp Ser Gln Ser Ala Gly Leu Phe Lys Thr Glu Arg 
            420                 425                 430         


Leu Glu Glu Phe Pro Gly Ser Thr Val Asp Leu Pro Pro Ala Pro Pro 
        435                 440                 445             


Leu Pro Pro Leu Pro Pro Pro Pro Gly Pro Pro Pro Pro Tyr His Ala 
    450                 455                 460                 


His Ala His Leu His His Pro Glu Leu Gly Pro His Ala Gln Gln Leu 
465                 470                 475                 480 


Ala Leu Pro Gln Ala Thr Leu Asp Asp Asp Gly Glu Met Asp Gly Ile 
                485                 490                 495     


Gly Gly Lys His Cys Cys Arg Trp Ile Asp Cys Ser Ala Leu Tyr Asp 
            500                 505                 510         


Gln Gln Glu Glu Leu Val Arg His Ile Glu Lys Val His Ile Asp Gln 
        515                 520                 525             


Arg Lys Gly Glu Asp Phe Thr Cys Phe Trp Ala Gly Cys Pro Arg Arg 
    530                 535                 540                 


Tyr Lys Pro Phe Asn Ala Arg Tyr Lys Leu Leu Ile His Met Arg Val 
545                 550                 555                 560 


His Ser Gly Glu Lys Pro Asn Lys Cys Thr Phe Glu Gly Cys Glu Lys 
                565                 570                 575     


Ala Phe Ser Arg Leu Glu Asn Leu Lys Ile His Leu Arg Ser His Thr 
            580                 585                 590         


Gly Glu Lys Pro Tyr Leu Cys Gln His Pro Gly Cys Gln Lys Ala Phe 
        595                 600                 605             


Ser Asn Ser Ser Asp Arg Ala Lys His Gln Arg Thr His Leu Asp Thr 
    610                 615                 620                 


Lys Pro Tyr Ala Cys Gln Ile Pro Gly Cys Thr Lys Arg Tyr Thr Asp 
625                 630                 635                 640 


Pro Ser Ser Leu Arg Lys His Val Lys Ala His Ser Ser Lys Glu Gln 
                645                 650                 655     


Gln Ala Arg Lys Lys Leu Arg Ser Ser Thr Glu Leu His Pro Asp Leu 
            660                 665                 670         


Leu Thr Asp Cys Leu Thr Val Gln Ser Leu Gln Pro Ala Thr Ser Pro 
        675                 680                 685             


Arg Asp Ala Ala Ala Glu Gly Thr Val Gly Arg Ser Pro Gly Pro Gly 
    690                 695                 700                 


Pro Asp Leu Tyr Ser Ala Pro Ile Phe Ser Ser Asn Tyr Ser Ser Arg 
705                 710                 715                 720 


Ser Gly Thr Ala Ala Gly Ala Val Pro Pro Pro His Pro Val Ser His 
                725                 730                 735     


Pro Ser Pro Gly His Asn Val Gln Gly Ser Pro His Asn Pro Ser Ser 
            740                 745                 750         


Gln Leu Pro Pro Leu Thr Ala Val Asp Ala Gly Ala Glu Arg Phe Ala 
        755                 760                 765             


Pro Ser Ala Pro Ser Pro His His Ile Ser Pro Arg Arg Val Pro Ala 
    770                 775                 780                 


Pro Ser Ser Ile Leu Gln Arg Thr Gln Pro Pro Tyr Thr Gln Gln Pro 
785                 790                 795                 800 


Ser Gly Ser His Leu Lys Ser Tyr Gln Pro Glu Thr Asn Ser Ser Phe 
                805                 810                 815     


Gln Pro Asn Gly Ile His Val His Gly Phe Tyr Gly Gln Leu Gln Lys 
            820                 825                 830         


Phe Cys Pro Pro His Tyr Pro Asp Ser Gln Arg Ile Val Pro Pro Val 
        835                 840                 845             


Ser Ser Cys Ser Val Val Pro Ser Phe Glu Asp Cys Leu Val Pro Thr 
    850                 855                 860                 


Ser Met Gly Gln Ala Ser Phe Asp Val Phe His Arg Ala Phe Ser Thr 
865                 870                 875                 880 


His Ser Gly Ile Thr Val Tyr Asp Leu Pro Ser Ser Ser Ser Ser Leu 
                885                 890                 895     


Phe Gly Glu Ser Leu Arg Ser Gly Ala Glu Asp Ala Thr Phe Leu Gln 
            900                 905                 910         


Ile Ser Thr Val Asp Arg Cys Pro Ser Gln Leu Ser Ser Val Tyr Thr 
        915                 920                 925             


Glu Gly 
    930 

<210>  364
<211>  6672
<212>  DNA
<213>  Homo sapiens

<400>  364
atcctttatg gttgaagggt gttggaggaa gcagagtttt catcagctgc tgaagtggca     60

actaatagag gtttgaatgg ccgtagaaaa atattgtgtt acttgtttgt tgtctagggg    120

ctcttggctt tgggcctcag tgcaagtcca ttggaaaagg cagctgcaac aatctagtgg    180

tcaccagcag tcccatgatg gttcagcgac tgggactcat ttcacctcca gcaagccagg    240

tctctacagc atgcaaccag atcagtccta gcttacagag ggcaatgaat gcagccaacc    300

tgaatatacc tccttcagat accaggtccc ttatttcgcg tgagtctttg gcgtccacga    360

ccttgagtct gacggaaagt cagtcggcct caagcatgaa gcaggagtgg tcccagggct    420

acagggccct cccttcgctc tccaaccacg gctctcagaa tggccttgat ctaggggatc    480

tccttagcct tcctcccggg acatccatgt ccagcaatag tgtctctaac tcattaccat    540

cctacctttt tggcacggaa agtagccact ctccttaccc tagtcctcgg cactcatcca    600

ccaggtccca ctcggcccgc tccaagaaga gagcgctgtc cttgtccccg ctgtccgatg    660

gcatcgggat agatttcaat accatcatcc gcacgtcgcc cacgtccttg gtggcctaca    720

tcaacgggtc gagggcttcg ccggccaacc tgtccccgca gccggaggtc tacgggcatt    780

tcctgggcgt gcgcggcagc tgcattcccc agccgcgccc ggtgcccggc agccagaagg    840

gcgtgctggt ggcccctgga ggcctggcgc tgccggccta cggcgaggac ggggccctgg    900

agcacgagcg catgcaacag ctggagcacg gcggcctgca gccaggcctg gtcaaccaca    960

tggtggtgca gcatggcctg ccgggccccg acagccagtc ggccggcctg ttcaagaccg   1020

aacgcctgga ggagttcccg ggcagcaccg tagacctacc ccccgcgcct ccgctccctc   1080

ctctgccgcc gcccccaggc cccccacccc cttaccatgc ccatgcgcac cttcaccacc   1140

cggagctcgg gccccacgcc cagcagctgg ccttgcccca ggccaccctg gacgacgacg   1200

gggagatgga cggcatcggg ggcaagcatt gctgccgctg gatcgactgc agcgccctgt   1260

acgaccagca ggaggagctc gtgcggcaca tcgagaaggt ccacatcgac cagcgcaaag   1320

gggaggactt cacttgcttc tgggccggtt gccctcgaag atacaagccc ttcaacgccc   1380

gctataaact gctgatccac atgagagtcc actctgggga gaagcccaac aagtgtacgt   1440

ttgaaggttg cgagaaggcc ttttcaaggc ttgaaaatct caagatccac ttgcggagcc   1500

acacaggcga gaagccgtat ttgtgccagc atccgggttg tcagaaggcc ttcagtaact   1560

ccagtgaccg cgccaaacac cagcggacgc atctggacac caaaccttat gcttgtcaaa   1620

ttccaggatg taccaaacgc tacacagacc caagttccct aagaaagcat gtgaaggcac   1680

attcttccaa agagcaacaa gcaaggaaaa agttgcggtc cagcacagag ctccatccag   1740

acctgctcac agattgcctc accgtgcagt ccctgcagcc ggccacttcc cctagagatg   1800

ctgctgctga agggaccgtg ggacgctccc ctggacccgg gcctgacctc tattcagctc   1860

ccattttctc cagcaattat tcaagccgaa gtggaacagc tgctggggcc gtaccacccc   1920

cacatcctgt cagtcaccct tctccaggac ataatgtaca ggggagccct cacaacccct   1980

cctcccagtt acctccactc acagctgtgg acgcaggagc tgagaggttt gcaccttctg   2040

ctccatctcc tcaccacatc agcccccgga gagttccagc tccttcttca atactgcaaa   2100

gaacacagcc tccctatacc cagcagccat caggttcaca cctgaagtcc tatcagccag   2160

aaacaaactc ttcttttcaa ccaaatggta tccatgtcca tggattttat gggcagctgc   2220

agaagttctg tcccccacac taccccgatt cccagagaat tgtgccgcct gtcagctcct   2280

gcagtgtggt gccttcgttt gaggactgcc tagtccctac atccatgggc caggccagtt   2340

ttgatgtttt ccacagagcc ttctcgactc actcgggcat tacagtgtat gatttacctt   2400

caagttcctc gagcctcttt ggggagtctc tccgcagcgg ggctgaagat gctaccttct   2460

tgcagatcag caccgtggac cgctgtccta gccagctctc ctctgtctac accgaaggct   2520

aaaagctctc ttggccactc ctgcacaccc aggaccttga tgttgcttgc caccttttgt   2580

tttcgtactc tcacagactg cttgaggaag gatgtcagcc caatcagcgg gccctgcaga   2640

gttactgatg ttctttcaga aggcaggact gaatggcaga gctagctttg caggaatcat   2700

tacagttgct cctttttctc tctggttttc ctggactatg tgaccaggag gactgtcttt   2760

tcaaagggaa tttagagcct cactctcctg gatacctgtt acttcctggc tgtcaaccct   2820

taaaggaccc cagtgaaatg atgtgcatat gaaaatgtag tttggggatg actctacctg   2880

aaaactccaa acagggaaaa agacctcaat tacgagaggc atagtgacct gcctcaccta   2940

atcctcaccc ttgctgctcc tgatgcaaag ccaggcacaa caagggaaat ccatgtccaa   3000

agcatagtgt ggtctcaact cttagaaact ccctgggttt cccttttctc ttagccacat   3060

gctaaccagt tgcttctcag tgtttctctt caatagaaaa ataaggtttt atatgccagc   3120

agcctatcct tgtttttgca ttttaaagac ttagttattt atacgtattt taaaatgaaa   3180

aaaaaatgta aaggtctgtg ctttggatgg aaatcattat tattgtaatc accccagcta   3240

tagacatttt gcacagctgt ggttctgcct ggccccacct ctagcatgtt agttttgcag   3300

ttagcaaagg ttacctgagg gaaatggagt gggcacctcc cgcaccaaca gtcctgtagc   3360

tggaaccttc ctgagttgac tgtttagtaa ctccacctca aagactgtgt tcaaagaaaa   3420

atgttgtttg actggtttac ccattgcctc cactctggtg ctgcacccag agaagtgcca   3480

gatgtgagaa ctgggacaga ctgagtcatg tgccagcttc ccttggaaaa ccaaacctag   3540

tgatacttga cttccagtgc tcagatttta ctaacgtttt tcaggatatc cactcatctg   3600

tctgtctctt ccctacactt ctctccaccc tctttttgca tccctcttac cctcttcctg   3660

actgtggttc atatatcccc accagccgcc attgtctgat catcttggga aggtagaggt   3720

gacagttctc gaaaagtcta cagaaagagg caattctttt tctgagttcc agtttgaagg   3780

cctggaattt tcacatagca cttggtcgaa aatatcaagc ctaaatagga agtcattttc   3840

tgtgacacct ctacatagct attacagatc ctaagtccta gggcatcagc tataaaaatt   3900

ggccagtccc aaagacacag taagttctaa cattctggta ctatcatatt tcaagtattt   3960

tttctcactt tttaaaaatg tttttctgaa caaaagtgaa acaatgccat ttatcaaact   4020

gagatcatta caatcttcaa caagacaact aaaacagctt gatgttagat gggattctgt   4080

gacagtttgt atactgacag gtccttccag tctccctcca cagtcccaca agcggaagta   4140

ttctacctga ttccagagtt cattccaaca tgcagtagaa tgaggtgaat gaagaaccaa   4200

gtgtgggttt tgttttcaca gtgcacttgg tcaatctagt ttctctgagt agtgggctgt   4260

attctaagaa aagctttcac gtagacgtca aagtctgcaa aagagatgag ttagccactt   4320

taaaaaacct gctctgcttt acaaaagatg cacaccaggc ttcctttaca agtgaactcc   4380

aaggctgctt gtaaagtacc acccttcctg cagactttgt gggtcgtgtc acttggccta   4440

aacaagtggc ctaacatatg catgctcaca gctagtagca tccctcatgc gtcctttgtc   4500

atactctgga aagaaaaaaa ctctgctatc ttcagagaaa ccatctattc atacttaaat   4560

atggaagcct ttacaaggaa ctcaaaatac atttcatttc atttgtacaa tgagaaaaaa   4620

gatgaaaagg caaggttgtt attgcagttg acattgtcag ccctgccttt tggctttatg   4680

taatttaaaa tagaaagggg gaaggaggac aagacagaag ctcaacttta gaaaccatgg   4740

acatcacctc cctctttgag aggagctgct tgtgaaccag gctccagtct tcctgtggcc   4800

tctcacagta accctgcccc tttcttacct cacaggggca agagggactc taaagagggc   4860

gtaagcaata gaggcacctg cagccctcct tcctcagcag gaaatcaatg tggagcccca   4920

gagggacatt ttatctcaga gagagcatgc tggccacagg acccagtgca gccctgcttc   4980

ccgcaccgtg ggtctttcct gatagctgca ggcttgagat tgcagcctca ggataggaca   5040

cgttcagatg ccttccagac tacacacact atgcttagat tcgagagtct ttcctgacct   5100

taaaatttgt cccttgctta ctttcacact gcagaagatt tatatatata ttcatcatta   5160

tttttgcagc agtacaagtg gaaacttcaa aaaaatcatt ccctttcatg tcctggtctt   5220

tttaagtctt gatatgtaac cattttcata aatgtccaaa cagagattgt cattcccctt   5280

aaaaacagaa acaaaacaca aaactagtgc ttgtgaaaac acacagcgca aagacaatta   5340

tcctattgca ttaaaaaaaa aatcagtctg cctagagaca tttcattggc tgcattgtct   5400

taattcccta acgaaactgc atcaaaatgt cagttgtaat ttagcctctg atcagctgtt   5460

aaatattatt taaatattta caggtcctgt ggggtatctc ccattaccca tgtcgccctc   5520

aaattacata agcgatcata aaataagaag aaaaaaaaag gtctttagta gatcacagca   5580

gagttaccac tgataagagt gttggctttg ttcagttgtt tctaaattac cagccgtcaa   5640

gcacagtagc ccctaaaacc aattttgagc aaggataaat tcaactccct catctgagaa   5700

ccttgacttt ccagttgcct tgaagtattg ggaatagtaa ctgtacattt tcaatttaat   5760

tatttggtat tttatttgac tgtcttggcc atgtcatttt atggaagcat ttttaaatag   5820

cactttttgt tagtggtgtg gaatttctgc ggttattatt tttttttttt tttgcaacag   5880

atgaagcaaa aaaaaaaaag cactcattgg agaaatagtg agtgtaaaaa gagatttatt   5940

ttgtacagac agcaaagtat cctgtgtaat gttgctgaca taaagcactt tgggggaaaa   6000

aagtggaaat ctgttttcca taaatcacac agactcttgt acatagttat atacactcac   6060

gtagagaaat gaactgcata tatcatactg gatatggggc cgattttact ctagaggcac   6120

atctggtgct tattgtcata aatcttttaa agaattaggt acactttttt ctattaatat   6180

gtatagtttt gtgatttgtc acagttatgt ttcatataat cataagttat tttgtcttgt   6240

tcatgaagtc ctttttttat gtcaaaagta aaatgaaggg attgtgcact tggtacagaa   6300

taaaactgga aatagagaag acgccctcct gcctaaaatc ctccttcagc ctgtcggttt   6360

aaaacacaat ggcaaccatc attgtttgtt tgtttgtttt tttgttttgt tttaccatca   6420

gcctcttaca tactgggaat ggtaattata attaaaggca gatgatgcgg gagggaatgt   6480

tcaagtccag ctttaaaatg ctgcattgct ttgggccaga gctgtagcct ggatttaatt   6540

atagatatga ggaggaaatg gcagtaaaaa tgaatgtctc cctgagtcct ttacatgttg   6600

ggagtgtcca taaataaaac atgaagtttt atttcatcag atttaattaa agcttttata   6660

catgttaaaa aa                                                       6672


<210>  365
<211>  775
<212>  PRT
<213>  Homo sapiens

<400>  365


Met Met Val Gln Arg Leu Gly Leu Ile Ser Pro Pro Ala Ser Gln Val 
1               5                   10                  15      


Ser Thr Ala Cys Asn Gln Ile Ser Pro Ser Leu Gln Arg Ala Met Asn 
            20                  25                  30          


Ala Ala Asn Leu Asn Ile Pro Pro Ser Asp Thr Arg Ser Leu Ile Ser 
        35                  40                  45              


Arg Glu Ser Leu Ala Ser Thr Thr Leu Ser Leu Thr Glu Ser Gln Ser 
    50                  55                  60                  


Ala Ser Ser Met Lys Gln Glu Trp Ser Gln Gly Tyr Arg Ala Leu Pro 
65                  70                  75                  80  


Ser Leu Ser Asn His Gly Ser Gln Asn Gly Leu Asp Leu Gly Asp Leu 
                85                  90                  95      


Leu Ser Leu Pro Pro Gly Thr Ser Met Ser Ser Asn Ser Val Ser Asn 
            100                 105                 110         


Ser Leu Pro Ser Tyr Leu Phe Gly Thr Glu Ser Ser His Ser Pro Tyr 
        115                 120                 125             


Pro Ser Pro Arg His Ser Ser Thr Arg Ser His Ser Ala Arg Ser Lys 
    130                 135                 140                 


Lys Arg Ala Leu Ser Leu Ser Pro Leu Ser Asp Gly Ile Gly Ile Asp 
145                 150                 155                 160 


Phe Asn Thr Ile Ile Arg Thr Ser Pro Thr Ser Leu Val Ala Tyr Ile 
                165                 170                 175     


Asn Gly Ser Arg Ala Ser Pro Ala Asn Leu Ser Pro Gln Pro Glu Val 
            180                 185                 190         


Tyr Gly His Phe Leu Gly Val Arg Gly Ser Cys Ile Pro Gln Pro Arg 
        195                 200                 205             


Pro Val Pro Gly Ser Gln Lys Gly Val Leu Val Ala Pro Gly Gly Leu 
    210                 215                 220                 


Ala Leu Pro Ala Tyr Gly Glu Asp Gly Ala Leu Glu His Glu Arg Met 
225                 230                 235                 240 


Gln Gln Leu Glu His Gly Gly Leu Gln Pro Gly Leu Val Asn His Met 
                245                 250                 255     


Val Val Gln His Gly Leu Pro Gly Pro Asp Ser Gln Ser Ala Gly Leu 
            260                 265                 270         


Phe Lys Thr Glu Arg Leu Glu Glu Phe Pro Gly Ser Thr Val Asp Leu 
        275                 280                 285             


Pro Pro Ala Pro Pro Leu Pro Pro Leu Pro Pro Pro Pro Gly Pro Pro 
    290                 295                 300                 


Pro Pro Tyr His Ala His Ala His Leu His His Pro Glu Leu Gly Pro 
305                 310                 315                 320 


His Ala Gln Gln Leu Ala Leu Pro Gln Ala Thr Leu Asp Asp Asp Gly 
                325                 330                 335     


Glu Met Asp Gly Ile Gly Gly Lys His Cys Cys Arg Trp Ile Asp Cys 
            340                 345                 350         


Ser Ala Leu Tyr Asp Gln Gln Glu Glu Leu Val Arg His Ile Glu Lys 
        355                 360                 365             


Val His Ile Asp Gln Arg Lys Gly Glu Asp Phe Thr Cys Phe Trp Ala 
    370                 375                 380                 


Gly Cys Pro Arg Arg Tyr Lys Pro Phe Asn Ala Arg Tyr Lys Leu Leu 
385                 390                 395                 400 


Ile His Met Arg Val His Ser Gly Glu Lys Pro Asn Lys Cys Thr Phe 
                405                 410                 415     


Glu Gly Cys Glu Lys Ala Phe Ser Arg Leu Glu Asn Leu Lys Ile His 
            420                 425                 430         


Leu Arg Ser His Thr Gly Glu Lys Pro Tyr Leu Cys Gln His Pro Gly 
        435                 440                 445             


Cys Gln Lys Ala Phe Ser Asn Ser Ser Asp Arg Ala Lys His Gln Arg 
    450                 455                 460                 


Thr His Leu Asp Thr Lys Pro Tyr Ala Cys Gln Ile Pro Gly Cys Thr 
465                 470                 475                 480 


Lys Arg Tyr Thr Asp Pro Ser Ser Leu Arg Lys His Val Lys Ala His 
                485                 490                 495     


Ser Ser Lys Glu Gln Gln Ala Arg Lys Lys Leu Arg Ser Ser Thr Glu 
            500                 505                 510         


Leu His Pro Asp Leu Leu Thr Asp Cys Leu Thr Val Gln Ser Leu Gln 
        515                 520                 525             


Pro Ala Thr Ser Pro Arg Asp Ala Ala Ala Glu Gly Thr Val Gly Arg 
    530                 535                 540                 


Ser Pro Gly Pro Gly Pro Asp Leu Tyr Ser Ala Pro Ile Phe Ser Ser 
545                 550                 555                 560 


Asn Tyr Ser Ser Arg Ser Gly Thr Ala Ala Gly Ala Val Pro Pro Pro 
                565                 570                 575     


His Pro Val Ser His Pro Ser Pro Gly His Asn Val Gln Gly Ser Pro 
            580                 585                 590         


His Asn Pro Ser Ser Gln Leu Pro Pro Leu Thr Ala Val Asp Ala Gly 
        595                 600                 605             


Ala Glu Arg Phe Ala Pro Ser Ala Pro Ser Pro His His Ile Ser Pro 
    610                 615                 620                 


Arg Arg Val Pro Ala Pro Ser Ser Ile Leu Gln Arg Thr Gln Pro Pro 
625                 630                 635                 640 


Tyr Thr Gln Gln Pro Ser Gly Ser His Leu Lys Ser Tyr Gln Pro Glu 
                645                 650                 655     


Thr Asn Ser Ser Phe Gln Pro Asn Gly Ile His Val His Gly Phe Tyr 
            660                 665                 670         


Gly Gln Leu Gln Lys Phe Cys Pro Pro His Tyr Pro Asp Ser Gln Arg 
        675                 680                 685             


Ile Val Pro Pro Val Ser Ser Cys Ser Val Val Pro Ser Phe Glu Asp 
    690                 695                 700                 


Cys Leu Val Pro Thr Ser Met Gly Gln Ala Ser Phe Asp Val Phe His 
705                 710                 715                 720 


Arg Ala Phe Ser Thr His Ser Gly Ile Thr Val Tyr Asp Leu Pro Ser 
                725                 730                 735     


Ser Ser Ser Ser Leu Phe Gly Glu Ser Leu Arg Ser Gly Ala Glu Asp 
            740                 745                 750         


Ala Thr Phe Leu Gln Ile Ser Thr Val Asp Arg Cys Pro Ser Gln Leu 
        755                 760                 765             


Ser Ser Val Tyr Thr Glu Gly 
    770                 775 

<210>  366
<211>  1378
<212>  DNA
<213>  Homo sapiens

<400>  366
agctgcagca aaatgaaagc aacaggagct gctccgggga ctgcttttgc cagtacccag     60

aatcagtgct caggctcaga aatcctggat agaaagagca ttttataaaa gagaatgtgt    120

ccacatcata cccagcacca aagaccccca taggtgttgc tgtgggcgtc tgataggcca    180

gcatgttggc ctcaccccca gtatctccgt gcttcagaat gagaaaaatg aaagtcgcct    240

ctcccgaaat gacatccagt ctgaaaagtg gtccatcagc aaacacactc aactcagccc    300

tacggatgct tttgggacca ttgagttcca aggaggtggc cattccaaca aagccatgta    360

tgtgcgagta tcttttgata caaaacctga tctcctctta cacctgatga ccaaggaatg    420

gcagttggag cttcccaagc ttctcatctc tgtccatggg ggcctgcaga actttgaact    480

ccagccaaaa ctcaagcaag tctttgggaa agggctcatc aaagcagcaa tgacaactgg    540

agcgtggata ttcactggag gggttaacac aggtgttatt cgtcatgttg gcgatgcctt    600

gaaggatcat gcctctaagt ctcgaggaaa gatatgcacc ataggtattg ccccctgggg    660

aattgtggaa aaccaggagg acctcattgg aagagatgtt gtccggccat accagaccat    720

gtccaatccc atgagcaagc tcactgttct caacagcatg cattcccact tcattctggc    780

tgacaacggg accactggaa aatatggagc agaggtgaaa cttcgaagac aactggaaaa    840

gcatatttca ctccagaaga taaacacaag atgcctgccg tttttctctc ttgactcccg    900

cttgttttat tcattttggg gtagttgcca gttagactca gttggaatcg gtcaaggtgt    960

tcctgtggtg gcactcatag tggaaggagg acccaatgtg atctcgattg ttttggagta   1020

ccttcgagac acccctcccg tgccagtggt tgtctgtgat gggagtggac gggcatcgga   1080

catcctggcc tttgggcata aatactcaga agaaggcggg taggtaactt tccaggcccc   1140

atggaagaac cctaaagcct gtttggaaac gagggtatga gtggattatg ttttcagtag   1200

ctcaaccaag acctcaaatc aaaacaagct atgaacaaat tgtctaaaaa atgtctgtca   1260

tgggagggct gtggtgaaga acagagaaac atattctaaa tgtcctgtga agtgggaaat   1320

tctatgaaag ctacacggat aataaaaagg gtgaggaaaa gaaaaaaaaa aaaaaaaa     1378


<210>  367
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  367


Met Tyr Val Arg Val Ser Phe Asp Thr Lys Pro Asp Leu Leu Leu His 
1               5                   10                  15      


Leu Met Thr Lys Glu Trp Gln Leu Glu Leu Pro Lys Leu Leu Ile Ser 
            20                  25                  30          


Val His Gly Gly Leu Gln Asn Phe Glu Leu Gln Pro Lys Leu Lys Gln 
        35                  40                  45              


Val Phe Gly Lys Gly Leu Ile Lys Ala Ala Met Thr Thr Gly Ala Trp 
    50                  55                  60                  


Ile Phe Thr Gly Gly Val Asn Thr Gly Val Ile Arg His Val Gly Asp 
65                  70                  75                  80  


Ala Leu Lys Asp His Ala Ser Lys Ser Arg Gly Lys Ile Cys Thr Ile 
                85                  90                  95      


Gly Ile Ala Pro Trp Gly Ile Val Glu Asn Gln Glu Asp Leu Ile Gly 
            100                 105                 110         


Arg Asp Val Val Arg Pro Tyr Gln Thr Met Ser Asn Pro Met Ser Lys 
        115                 120                 125             


Leu Thr Val Leu Asn Ser Met His Ser His Phe Ile Leu Ala Asp Asn 
    130                 135                 140                 


Gly Thr Thr Gly Lys Tyr Gly Ala Glu Val Lys Leu Arg Arg Gln Leu 
145                 150                 155                 160 


Glu Lys His Ile Ser Leu Gln Lys Ile Asn Thr Arg Cys Leu Pro Phe 
                165                 170                 175     


Phe Ser Leu Asp Ser Arg Leu Phe Tyr Ser Phe Trp Gly Ser Cys Gln 
            180                 185                 190         


Leu Asp Ser Val Gly Ile Gly Gln Gly Val Pro Val Val Ala Leu Ile 
        195                 200                 205             


Val Glu Gly Gly Pro Asn Val Ile Ser Ile Val Leu Glu Tyr Leu Arg 
    210                 215                 220                 


Asp Thr Pro Pro Val Pro Val Val Val Cys Asp Gly Ser Gly Arg Ala 
225                 230                 235                 240 


Ser Asp Ile Leu Ala Phe Gly His Lys Tyr Ser Glu Glu Gly Gly 
                245                 250                 255 

<210>  368
<211>  6288
<212>  DNA
<213>  Homo sapiens

<400>  368
tccgaccaca ggctgttttg tgcaggctgt ccctcttctt caaaatcgtg catcccctcc     60

ccgaagcagc aggcagtgtg cctccattca gccacatttg gtatgcatga gcacggctgc    120

agagagaggg gaggtggctg ttttaagaag gttcaggggc tcaggcaagg ctacttgact    180

agtcttccaa gttccaggaa gcctctgccc taatggaatt tgcaggtgtg gagatgacca    240

tgggatgcca gagccgtggg ggaccgttta ttttctaggc attgctcagg ttttcagttt    300

cttgttttcc tggtggaatt tggaaggggt catgaatcag gctgatgctc ctcgacccct    360

aaactggacc atccggaagc tgtgccacgc agcctttctt ccatctgtca gacttctgaa    420

ggctcagaaa tcctggatag aaagagcatt ttataaaaga gaatgtgtcc acatcatacc    480

cagcaccaaa gacccccata ggtgttgctg tgggcgtctg ataggccagc atgttggcct    540

cacccccagt atctccgtgc ttcagaatga gaaaaatgaa agtcgcctct cccgaaatga    600

catccagtct gaaaagtggt ccatcagcaa acacactcaa ctcagcccta cggatgcttt    660

tgggaccatt gagttccaag gaggtggcca ttccaacaaa gccatgtatg tgcgagtatc    720

ttttgataca aaacctgatc tcctcttaca cctgatgacc aaggaatggc agttggagct    780

tcccaagctt ctcatctctg tccatggggg cctgcagaac tttgaactcc agccaaaact    840

caagcaagtc tttgggaaag ggctcatcaa agcagcaatg acaactggag cgtggatatt    900

cactggaggg gttaacacag gtgttattcg tcatgttggc gatgccttga aggatcatgc    960

ctctaagtct cgaggaaaga tatgcaccat aggtattgcc ccctggggaa ttgtggaaaa   1020

ccaggaggac ctcattggaa gagatgttgt ccggccatac cagaccatgt ccaatcccat   1080

gagcaagctc actgttctca acagcatgca ttcccacttc attctggctg acaacgggac   1140

cactggaaaa tatggagcag aggtgaaact tcgaagacaa ctggaaaagc atatttcact   1200

ccagaagata aacacaagaa tcggtcaagg tgttcctgtg gtggcactca tagtggaagg   1260

aggacccaat gtgatctcga ttgttttgga gtaccttcga gacacccctc ccgtgccagt   1320

ggttgtctgt gatgggagtg gacgggcatc ggacatcctg gcctttgggc ataaatactc   1380

agaagaaggc ggactgataa atgaatcttt gagggaccag ctgttggtga ctatacagaa   1440

gactttcaca tacactcgaa cccaagctca gcatctgttc atcatcctca tggagtgcat   1500

gaagaagaag gaattgatta cggtatttcg gatgggatca gaaggacacc aggacattga   1560

tttggctatc ctgacagctt tactcaaagg agccaatgcc tcggccccag accaactgag   1620

cttagcttta gcctggaaca gagtcgacat cgctcgcagc cagatcttta tttacgggca   1680

acagtggccg gtgggatctc tggagcaagc catgttggat gccttagttc tggacagagt   1740

ggattttgtg aaattactca tagagaatgg agtaagcatg caccgttttc tcaccatctc   1800

cagactagag gaattgtaca atacgagaca tgggccctca aatacattgt accacttggt   1860

cagggatgtc aaaaagggga acctgccccc agactacaga atcagcctga ttgacatcgg   1920

cctggtgatc gagtacctga tgggcggggc ttatcgctgc aactacacgc gcaagcgctt   1980

ccggaccctc taccacaacc tcttcggccc caagaggccc aaagccttga aactgctggg   2040

aatggaggat gatattccct tgaggcgagg aagaaagaca accaagaaac gtgaagaaga   2100

ggtggacatt gacttggatg atcctgagat caaccacttc cccttccctt tccatgagct   2160

catggtgtgg gctgttctca tgaagcggca gaagatggcc ctgttcttct ggcagcacgg   2220

tgaggaggcc atggccaagg ccctggtggc ctgcaagctc tgcaaagcca tggctcatga   2280

ggcctctgag aacgacatgg ttgacgacat ttcccaggag ctgaatcaca attccagaga   2340

ctttggccag ctggctgtgg agctcctgga ccagtcctac aagcaggacg aacagctggc   2400

catgaaactg ctgacgtatg agctgaagaa ctggagcaac gccacgtgcc tgcagcttgc   2460

cgtggctgcc aaacaccgcg acttcatcgc gcacacgtgc agccagatgc tgctcaccga   2520

catgtggatg ggccggctcc gcatgcgcaa gaactcaggc ctcaaggtaa ttctgggaat   2580

tctacttcct ccttcaattc tcagcttgga gttcaagaac aaagacgaca tgccctatat   2640

gtctcaggcc caggaaatcc acctccaaga gaaggaggca gaagaaccag agaagcccac   2700

aaaggaaaaa gaggaagagg acatggagct cacagcaatg ttgggacgaa acaacgggga   2760

gtcctccagg aagaaggatg aagaggaagt tcagagcaag caccggttaa tccccctcgg   2820

cagaaaaatc tatgaattct acaatgcacc catcgtgaag ttctggttct acacactggc   2880

gtatatcgga tacctgatgc tcttcaacta tatcgtgtta gtgaagatgg aacgctggcc   2940

gtccacccag gaatggatcg taatctccta tattttcacc ctgggaatag aaaagatgag   3000

agagattctg atgtcagagc cagggaagtt gctacagaaa gtgaaggtat ggctgcagga   3060

gtactggaat gtcacggacc tcatcgccat ccttctgttt tctgtcggaa tgatccttcg   3120

tctccaagac cagcccttca ggagtgacgg gagggtcatc tactgcgtga acatcattta   3180

ctggtatatc cgtctcctag acatcttcgg cgtgaacaag tatttgggcc cgtatgtaat   3240

gatgattgga aaaatgatga tagacatgat gtactttgtc atcattatgc tggtggttct   3300

gatgagcttt ggggtcgcca ggcaagccat cctttttccc aatgaggagc catcatggaa   3360

actggccaag aacatcttct acatgcccta ttggatgatt tatggggaag tgtttgcgga   3420

ccagatagac cctccctgtg gacagaatga gacccgagag gatggtaaaa taatccagct   3480

gcctccctgc aagacaggag cttggatcgt gccggccatc atggcctgct acctcttagt   3540

ggcaaacatc ttgctggtca acctcctcat tgctgtcttt aacaatacat tttttgaagt   3600

aaaatcgata tccaaccaag tctggaagtt tcagaggtat cagctcatca tgactttcca   3660

tgaaaggcca gttctgcccc caccactgat catcttcagc cacatgacca tgatattcca   3720

gcacctgtgc tgccgatgga ggaaacacga gagcgacccg gatgaaaggg actacggcct   3780

gaaactcttc ataaccgatg atgagctcaa gaaagtacat gactttgaag agcaatgcat   3840

agaagaatac ttcagagaaa aggatgatcg gttcaactca tctaatgatg agaggatacg   3900

ggtgacttca gaaagggtgg agaacatgtc tatgcggctg gaggaagtca acgagagaga   3960

gcactccatg aaggcttcac tccagaccgt ggacatccgg ctggcgcagc tggaagacct   4020

tatcgggcgc atggccacgg ccctggagcg cctgacaggt ctggagcggg ccgagtccaa   4080

caaaatccgc tcgaggacct cgtcagactg cacggacgcc gcctacattg tccgtcagag   4140

cagcttcaac agccaggaag ggaacacctt caagctccaa gagagtatag accctgcagg   4200

tgaggagacc atgtccccaa cttctccaac cttaatgccc cgtatgcgaa gccattcttt   4260

ctattcggtc aatatgaaag acaaaggtgg tatagaaaag ttggaaagta tttttaaaga   4320

aaggtccctg agcctacacc gggctactag ttcccactct gtagcaaaag aacccaaagc   4380

tcctgcagcc cctgccaaca ccttggccat tgttcctgat tccagaagac catcatcgtg   4440

tatagacatc tatgtctctg ctatggatga gctccactgt gatatagacc ctctggacaa   4500

ttccgtgaac atccttgggc tgggcgagcc aagcttttca actccagtac cttccacagc   4560

cccttcaagt agtgcctatg caacacttgc acccacagac agacctccaa gccggagcat   4620

tgattttgag gacatcacct ccatggacac tagatctttt tcttcagact acacccacct   4680

cccagaatgc caaaacccct gggactcaga gcctccgatg taccacacca ttgagcgttc   4740

caaaagtagc cgctacctag ccaccacacc ctttcttcta gaagaggctc ccattgtgaa   4800

atctcatagc tttatgtttt ccccctcaag gagctattat gccaactttg gggtgcctgt   4860

aaaaacagca gaatacacaa gtattacaga ctgtattgac acaaggtgtg tcaatgcccc   4920

tcaagcaatt gcggacagag ctgccttccc tggaggtctt ggagacaaag tggaggactt   4980

aacttgctgc catccagagc gagaagcaga actgagtcac cccagctctg acagtgagga   5040

gaatgaggcc aaaggccgca gagccaccat tgcaatatcc tcccaggagg gtgataactc   5100

agagagaacc ctgtccaaca acatcactgt tcccaagata gagcgcgcca acagctactc   5160

ggcagaggag ccaagtgcgc catatgcaca caccaggaag agcttctcca tcagtgacaa   5220

actcgacagg cagcggaaca cagcaagcct gcgaaatccc ttccagagaa gcaagtcctc   5280

caagccggag ggccgagggg acagcctgtc catgaggaga ctgtccagaa catcggcttt   5340

ccaaagcttt gaaagcaagc acaactaaac cttcttaata tccgccacag aaggctcaag   5400

aatccagccc taaaattctc tccaactcca gtttttcccc tttccttgaa tcatacctgc   5460

tttattctta gctgagcaaa acaagcaatg ctttgggagg tgttaactca aaggtgactt   5520

ctgggccaca gatcaagaaa gcatttgatc tgacccagtg ccagacacag gggatttaag   5580

gcatgttcac acttgctggg cagggagggg gaagagaggg agaaggaagg gttagagatg   5640

aatgtgtatc cgcagtcaca gcagaaagcc atgagagcag gggaaacaag gggcttcgag   5700

cacgctccat gccaggaggc atctgttgat ttctgaccat tatcaagagt tgtaggatgc   5760

agggctaaat tgcaaaataa aataaaatag ccagcgtaca caatgagata ttctaaactt   5820

ccattctgtt ttcttttcac attggctcca tcactggtga ctgatgaaga gcatcctctt   5880

tattcagtat aagccggcag caagcagttc tacctaacgt cccacatcct tctcatgcca   5940

acacttctgt aattgatcat tataaagaaa aaacaaggta acagtcatag ttcacctgtc   6000

tcttatctat tcacttctgg tgccacaact gtttatcctt ttttgaagaa aataagggaa   6060

cagaaatgcc tttttgtatt gcaatcgaaa tgaaagaaga gttgatgtta aaaaaacaaa   6120

agtcaagtga tttattatat acagtgggcg ttcaagtcta gtcgagcaag ctcaggagaa   6180

tgtaattaaa taattttata ttttttaatt tattttgtat ctcacctgtc atggatgaat   6240

tcattcactg aatatgtaat attgaactta aaaaaaaaaa aaaaaaaa                6288


<210>  369
<211>  1707
<212>  PRT
<213>  Homo sapiens

<400>  369


Met Pro Glu Pro Trp Gly Thr Val Tyr Phe Leu Gly Ile Ala Gln Val 
1               5                   10                  15      


Phe Ser Phe Leu Phe Ser Trp Trp Asn Leu Glu Gly Val Met Asn Gln 
            20                  25                  30          


Ala Asp Ala Pro Arg Pro Leu Asn Trp Thr Ile Arg Lys Leu Cys His 
        35                  40                  45              


Ala Ala Phe Leu Pro Ser Val Arg Leu Leu Lys Ala Gln Lys Ser Trp 
    50                  55                  60                  


Ile Glu Arg Ala Phe Tyr Lys Arg Glu Cys Val His Ile Ile Pro Ser 
65                  70                  75                  80  


Thr Lys Asp Pro His Arg Cys Cys Cys Gly Arg Leu Ile Gly Gln His 
                85                  90                  95      


Val Gly Leu Thr Pro Ser Ile Ser Val Leu Gln Asn Glu Lys Asn Glu 
            100                 105                 110         


Ser Arg Leu Ser Arg Asn Asp Ile Gln Ser Glu Lys Trp Ser Ile Ser 
        115                 120                 125             


Lys His Thr Gln Leu Ser Pro Thr Asp Ala Phe Gly Thr Ile Glu Phe 
    130                 135                 140                 


Gln Gly Gly Gly His Ser Asn Lys Ala Met Tyr Val Arg Val Ser Phe 
145                 150                 155                 160 


Asp Thr Lys Pro Asp Leu Leu Leu His Leu Met Thr Lys Glu Trp Gln 
                165                 170                 175     


Leu Glu Leu Pro Lys Leu Leu Ile Ser Val His Gly Gly Leu Gln Asn 
            180                 185                 190         


Phe Glu Leu Gln Pro Lys Leu Lys Gln Val Phe Gly Lys Gly Leu Ile 
        195                 200                 205             


Lys Ala Ala Met Thr Thr Gly Ala Trp Ile Phe Thr Gly Gly Val Asn 
    210                 215                 220                 


Thr Gly Val Ile Arg His Val Gly Asp Ala Leu Lys Asp His Ala Ser 
225                 230                 235                 240 


Lys Ser Arg Gly Lys Ile Cys Thr Ile Gly Ile Ala Pro Trp Gly Ile 
                245                 250                 255     


Val Glu Asn Gln Glu Asp Leu Ile Gly Arg Asp Val Val Arg Pro Tyr 
            260                 265                 270         


Gln Thr Met Ser Asn Pro Met Ser Lys Leu Thr Val Leu Asn Ser Met 
        275                 280                 285             


His Ser His Phe Ile Leu Ala Asp Asn Gly Thr Thr Gly Lys Tyr Gly 
    290                 295                 300                 


Ala Glu Val Lys Leu Arg Arg Gln Leu Glu Lys His Ile Ser Leu Gln 
305                 310                 315                 320 


Lys Ile Asn Thr Arg Ile Gly Gln Gly Val Pro Val Val Ala Leu Ile 
                325                 330                 335     


Val Glu Gly Gly Pro Asn Val Ile Ser Ile Val Leu Glu Tyr Leu Arg 
            340                 345                 350         


Asp Thr Pro Pro Val Pro Val Val Val Cys Asp Gly Ser Gly Arg Ala 
        355                 360                 365             


Ser Asp Ile Leu Ala Phe Gly His Lys Tyr Ser Glu Glu Gly Gly Leu 
    370                 375                 380                 


Ile Asn Glu Ser Leu Arg Asp Gln Leu Leu Val Thr Ile Gln Lys Thr 
385                 390                 395                 400 


Phe Thr Tyr Thr Arg Thr Gln Ala Gln His Leu Phe Ile Ile Leu Met 
                405                 410                 415     


Glu Cys Met Lys Lys Lys Glu Leu Ile Thr Val Phe Arg Met Gly Ser 
            420                 425                 430         


Glu Gly His Gln Asp Ile Asp Leu Ala Ile Leu Thr Ala Leu Leu Lys 
        435                 440                 445             


Gly Ala Asn Ala Ser Ala Pro Asp Gln Leu Ser Leu Ala Leu Ala Trp 
    450                 455                 460                 


Asn Arg Val Asp Ile Ala Arg Ser Gln Ile Phe Ile Tyr Gly Gln Gln 
465                 470                 475                 480 


Trp Pro Val Gly Ser Leu Glu Gln Ala Met Leu Asp Ala Leu Val Leu 
                485                 490                 495     


Asp Arg Val Asp Phe Val Lys Leu Leu Ile Glu Asn Gly Val Ser Met 
            500                 505                 510         


His Arg Phe Leu Thr Ile Ser Arg Leu Glu Glu Leu Tyr Asn Thr Arg 
        515                 520                 525             


His Gly Pro Ser Asn Thr Leu Tyr His Leu Val Arg Asp Val Lys Lys 
    530                 535                 540                 


Gly Asn Leu Pro Pro Asp Tyr Arg Ile Ser Leu Ile Asp Ile Gly Leu 
545                 550                 555                 560 


Val Ile Glu Tyr Leu Met Gly Gly Ala Tyr Arg Cys Asn Tyr Thr Arg 
                565                 570                 575     


Lys Arg Phe Arg Thr Leu Tyr His Asn Leu Phe Gly Pro Lys Arg Pro 
            580                 585                 590         


Lys Ala Leu Lys Leu Leu Gly Met Glu Asp Asp Ile Pro Leu Arg Arg 
        595                 600                 605             


Gly Arg Lys Thr Thr Lys Lys Arg Glu Glu Glu Val Asp Ile Asp Leu 
    610                 615                 620                 


Asp Asp Pro Glu Ile Asn His Phe Pro Phe Pro Phe His Glu Leu Met 
625                 630                 635                 640 


Val Trp Ala Val Leu Met Lys Arg Gln Lys Met Ala Leu Phe Phe Trp 
                645                 650                 655     


Gln His Gly Glu Glu Ala Met Ala Lys Ala Leu Val Ala Cys Lys Leu 
            660                 665                 670         


Cys Lys Ala Met Ala His Glu Ala Ser Glu Asn Asp Met Val Asp Asp 
        675                 680                 685             


Ile Ser Gln Glu Leu Asn His Asn Ser Arg Asp Phe Gly Gln Leu Ala 
    690                 695                 700                 


Val Glu Leu Leu Asp Gln Ser Tyr Lys Gln Asp Glu Gln Leu Ala Met 
705                 710                 715                 720 


Lys Leu Leu Thr Tyr Glu Leu Lys Asn Trp Ser Asn Ala Thr Cys Leu 
                725                 730                 735     


Gln Leu Ala Val Ala Ala Lys His Arg Asp Phe Ile Ala His Thr Cys 
            740                 745                 750         


Ser Gln Met Leu Leu Thr Asp Met Trp Met Gly Arg Leu Arg Met Arg 
        755                 760                 765             


Lys Asn Ser Gly Leu Lys Val Ile Leu Gly Ile Leu Leu Pro Pro Ser 
    770                 775                 780                 


Ile Leu Ser Leu Glu Phe Lys Asn Lys Asp Asp Met Pro Tyr Met Ser 
785                 790                 795                 800 


Gln Ala Gln Glu Ile His Leu Gln Glu Lys Glu Ala Glu Glu Pro Glu 
                805                 810                 815     


Lys Pro Thr Lys Glu Lys Glu Glu Glu Asp Met Glu Leu Thr Ala Met 
            820                 825                 830         


Leu Gly Arg Asn Asn Gly Glu Ser Ser Arg Lys Lys Asp Glu Glu Glu 
        835                 840                 845             


Val Gln Ser Lys His Arg Leu Ile Pro Leu Gly Arg Lys Ile Tyr Glu 
    850                 855                 860                 


Phe Tyr Asn Ala Pro Ile Val Lys Phe Trp Phe Tyr Thr Leu Ala Tyr 
865                 870                 875                 880 


Ile Gly Tyr Leu Met Leu Phe Asn Tyr Ile Val Leu Val Lys Met Glu 
                885                 890                 895     


Arg Trp Pro Ser Thr Gln Glu Trp Ile Val Ile Ser Tyr Ile Phe Thr 
            900                 905                 910         


Leu Gly Ile Glu Lys Met Arg Glu Ile Leu Met Ser Glu Pro Gly Lys 
        915                 920                 925             


Leu Leu Gln Lys Val Lys Val Trp Leu Gln Glu Tyr Trp Asn Val Thr 
    930                 935                 940                 


Asp Leu Ile Ala Ile Leu Leu Phe Ser Val Gly Met Ile Leu Arg Leu 
945                 950                 955                 960 


Gln Asp Gln Pro Phe Arg Ser Asp Gly Arg Val Ile Tyr Cys Val Asn 
                965                 970                 975     


Ile Ile Tyr Trp Tyr Ile Arg Leu Leu Asp Ile Phe Gly Val Asn Lys 
            980                 985                 990         


Tyr Leu Gly Pro Tyr Val Met Met  Ile Gly Lys Met Met  Ile Asp Met 
        995                 1000                 1005             


Met Tyr  Phe Val Ile Ile Met  Leu Val Val Leu Met  Ser Phe Gly 
    1010                 1015                 1020             


Val Ala  Arg Gln Ala Ile Leu  Phe Pro Asn Glu Glu  Pro Ser Trp 
    1025                 1030                 1035             


Lys Leu  Ala Lys Asn Ile Phe  Tyr Met Pro Tyr Trp  Met Ile Tyr 
    1040                 1045                 1050             


Gly Glu  Val Phe Ala Asp Gln  Ile Asp Pro Pro Cys  Gly Gln Asn 
    1055                 1060                 1065             


Glu Thr  Arg Glu Asp Gly Lys  Ile Ile Gln Leu Pro  Pro Cys Lys 
    1070                 1075                 1080             


Thr Gly  Ala Trp Ile Val Pro  Ala Ile Met Ala Cys  Tyr Leu Leu 
    1085                 1090                 1095             


Val Ala  Asn Ile Leu Leu Val  Asn Leu Leu Ile Ala  Val Phe Asn 
    1100                 1105                 1110             


Asn Thr  Phe Phe Glu Val Lys  Ser Ile Ser Asn Gln  Val Trp Lys 
    1115                 1120                 1125             


Phe Gln  Arg Tyr Gln Leu Ile  Met Thr Phe His Glu  Arg Pro Val 
    1130                 1135                 1140             


Leu Pro  Pro Pro Leu Ile Ile  Phe Ser His Met Thr  Met Ile Phe 
    1145                 1150                 1155             


Gln His  Leu Cys Cys Arg Trp  Arg Lys His Glu Ser  Asp Pro Asp 
    1160                 1165                 1170             


Glu Arg  Asp Tyr Gly Leu Lys  Leu Phe Ile Thr Asp  Asp Glu Leu 
    1175                 1180                 1185             


Lys Lys  Val His Asp Phe Glu  Glu Gln Cys Ile Glu  Glu Tyr Phe 
    1190                 1195                 1200             


Arg Glu  Lys Asp Asp Arg Phe  Asn Ser Ser Asn Asp  Glu Arg Ile 
    1205                 1210                 1215             


Arg Val  Thr Ser Glu Arg Val  Glu Asn Met Ser Met  Arg Leu Glu 
    1220                 1225                 1230             


Glu Val  Asn Glu Arg Glu His  Ser Met Lys Ala Ser  Leu Gln Thr 
    1235                 1240                 1245             


Val Asp  Ile Arg Leu Ala Gln  Leu Glu Asp Leu Ile  Gly Arg Met 
    1250                 1255                 1260             


Ala Thr  Ala Leu Glu Arg Leu  Thr Gly Leu Glu Arg  Ala Glu Ser 
    1265                 1270                 1275             


Asn Lys  Ile Arg Ser Arg Thr  Ser Ser Asp Cys Thr  Asp Ala Ala 
    1280                 1285                 1290             


Tyr Ile  Val Arg Gln Ser Ser  Phe Asn Ser Gln Glu  Gly Asn Thr 
    1295                 1300                 1305             


Phe Lys  Leu Gln Glu Ser Ile  Asp Pro Ala Gly Glu  Glu Thr Met 
    1310                 1315                 1320             


Ser Pro  Thr Ser Pro Thr Leu  Met Pro Arg Met Arg  Ser His Ser 
    1325                 1330                 1335             


Phe Tyr  Ser Val Asn Met Lys  Asp Lys Gly Gly Ile  Glu Lys Leu 
    1340                 1345                 1350             


Glu Ser  Ile Phe Lys Glu Arg  Ser Leu Ser Leu His  Arg Ala Thr 
    1355                 1360                 1365             


Ser Ser  His Ser Val Ala Lys  Glu Pro Lys Ala Pro  Ala Ala Pro 
    1370                 1375                 1380             


Ala Asn  Thr Leu Ala Ile Val  Pro Asp Ser Arg Arg  Pro Ser Ser 
    1385                 1390                 1395             


Cys Ile  Asp Ile Tyr Val Ser  Ala Met Asp Glu Leu  His Cys Asp 
    1400                 1405                 1410             


Ile Asp  Pro Leu Asp Asn Ser  Val Asn Ile Leu Gly  Leu Gly Glu 
    1415                 1420                 1425             


Pro Ser  Phe Ser Thr Pro Val  Pro Ser Thr Ala Pro  Ser Ser Ser 
    1430                 1435                 1440             


Ala Tyr  Ala Thr Leu Ala Pro  Thr Asp Arg Pro Pro  Ser Arg Ser 
    1445                 1450                 1455             


Ile Asp  Phe Glu Asp Ile Thr  Ser Met Asp Thr Arg  Ser Phe Ser 
    1460                 1465                 1470             


Ser Asp  Tyr Thr His Leu Pro  Glu Cys Gln Asn Pro  Trp Asp Ser 
    1475                 1480                 1485             


Glu Pro  Pro Met Tyr His Thr  Ile Glu Arg Ser Lys  Ser Ser Arg 
    1490                 1495                 1500             


Tyr Leu  Ala Thr Thr Pro Phe  Leu Leu Glu Glu Ala  Pro Ile Val 
    1505                 1510                 1515             


Lys Ser  His Ser Phe Met Phe  Ser Pro Ser Arg Ser  Tyr Tyr Ala 
    1520                 1525                 1530             


Asn Phe  Gly Val Pro Val Lys  Thr Ala Glu Tyr Thr  Ser Ile Thr 
    1535                 1540                 1545             


Asp Cys  Ile Asp Thr Arg Cys  Val Asn Ala Pro Gln  Ala Ile Ala 
    1550                 1555                 1560             


Asp Arg  Ala Ala Phe Pro Gly  Gly Leu Gly Asp Lys  Val Glu Asp 
    1565                 1570                 1575             


Leu Thr  Cys Cys His Pro Glu  Arg Glu Ala Glu Leu  Ser His Pro 
    1580                 1585                 1590             


Ser Ser  Asp Ser Glu Glu Asn  Glu Ala Lys Gly Arg  Arg Ala Thr 
    1595                 1600                 1605             


Ile Ala  Ile Ser Ser Gln Glu  Gly Asp Asn Ser Glu  Arg Thr Leu 
    1610                 1615                 1620             


Ser Asn  Asn Ile Thr Val Pro  Lys Ile Glu Arg Ala  Asn Ser Tyr 
    1625                 1630                 1635             


Ser Ala  Glu Glu Pro Ser Ala  Pro Tyr Ala His Thr  Arg Lys Ser 
    1640                 1645                 1650             


Phe Ser  Ile Ser Asp Lys Leu  Asp Arg Gln Arg Asn  Thr Ala Ser 
    1655                 1660                 1665             


Leu Arg  Asn Pro Phe Gln Arg  Ser Lys Ser Ser Lys  Pro Glu Gly 
    1670                 1675                 1680             


Arg Gly  Asp Ser Leu Ser Met  Arg Arg Leu Ser Arg  Thr Ser Ala 
    1685                 1690                 1695             


Phe Gln  Ser Phe Glu Ser Lys  His Asn 
    1700                 1705         

<210>  370
<211>  5940
<212>  DNA
<213>  Homo sapiens

<400>  370
agctgcagca aaatgaaagc aacaggagct gctccgggga ctgcttttgc cagtacccag     60

aatcagtgct caggctcaga aatcctggat agaaagagca ttttataaaa gagaatgtgt    120

ccacatcata cccagcacca aagaccccca taggtgttgc tgtgggcgtc tgataggcca    180

gcatgttggc ctcaccccca gtatctccgt gcttcagaat gagaaaaatg aaagtcgcct    240

ctcccgaaat gacatccagt ctgaaaagtg gtccatcagc aaacacactc aactcagccc    300

tacggatgct tttgggacca ttgagttcca aggaggtggc cattccaaca aagccatgta    360

tgtgcgagta tcttttgata caaaacctga tctcctctta cacctgatga ccaaggaatg    420

gcagttggag cttcccaagc ttctcatctc tgtccatggg ggcctgcaga actttgaact    480

ccagccaaaa ctcaagcaag tctttgggaa agggctcatc aaagcagcaa tgacaactgg    540

agcgtggata ttcactggag gggttaacac aggtgttatt cgtcatgttg gcgatgcctt    600

gaaggatcat gcctctaagt ctcgaggaaa gatatgcacc ataggtattg ccccctgggg    660

aattgtggaa aaccaggagg acctcattgg aagagatgtt gtccggccat accagaccat    720

gtccaatccc atgagcaagc tcactgttct caacagcatg cattcccact tcattctggc    780

tgacaacggg accactggaa aatatggagc agaggtgaaa cttcgaagac aactggaaaa    840

gcatatttca ctccagaaga taaacacaag aatcggtcaa ggtgttcctg tggtggcact    900

catagtggaa ggaggaccca atgtgatctc gattgttttg gagtaccttc gagacacccc    960

tcccgtgcca gtggttgtct gtgatgggag tggacgggca tcggacatcc tggcctttgg   1020

gcataaatac tcagaagaag gcggactgat aaatgaatct ttgagggacc agctgttggt   1080

gactatacag aagactttca catacactcg aacccaagct cagcatctgt tcatcatcct   1140

catggagtgc atgaagaaga aggaattgat tacggtattt cggatgggat cagaaggaca   1200

ccaggacatt gatttggcta tcctgacagc tttactcaaa ggagccaatg cctcggcccc   1260

agaccaactg agcttagctt tagcctggaa cagagtcgac atcgctcgca gccagatctt   1320

tatttacggg caacagtggc cggtgggatc tctggagcaa gccatgttgg atgccttagt   1380

tctggacaga gtggattttg tgaaattact catagagaat ggagtaagca tgcaccgttt   1440

tctcaccatc tccagactag aggaattgta caatacgaga catgggccct caaatacatt   1500

gtaccacttg gtcagggatg tcaaaaaggg gaacctgccc ccagactaca gaatcagcct   1560

gattgacatc ggcctggtga tcgagtacct gatgggcggg gcttatcgct gcaactacac   1620

gcgcaagcgc ttccggaccc tctaccacaa cctcttcggc cccaagaggc ccaaagcctt   1680

gaaactgctg ggaatggagg atgatattcc cttgaggcga ggaagaaaga caaccaagaa   1740

acgtgaagaa gaggtggaca ttgacttgga tgatcctgag atcaaccact tccccttccc   1800

tttccatgag ctcatggtgt gggctgttct catgaagcgg cagaagatgg ccctgttctt   1860

ctggcagcac ggtgaggagg ccatggccaa ggccctggtg gcctgcaagc tctgcaaagc   1920

catggctcat gaggcctctg agaacgacat ggttgacgac atttcccagg agctgaatca   1980

caattccaga gactttggcc agctggctgt ggagctcctg gaccagtcct acaagcagga   2040

cgaacagctg gccatgaaac tgctgacgta tgagctgaag aactggagca acgccacgtg   2100

cctgcagctt gccgtggctg ccaaacaccg cgacttcatc gcgcacacgt gcagccagat   2160

gctgctcacc gacatgtgga tgggccggct ccgcatgcgc aagaactcag gcctcaaggt   2220

aattctggga attctacttc ctccttcaat tctcagcttg gagttcaaga acaaagacga   2280

catgccctat atgtctcagg cccaggaaat ccacctccaa gagaaggagg cagaagaacc   2340

agagaagccc acaaaggaaa aagaggaaga ggacatggag ctcacagcaa tgttgggacg   2400

aaacaacggg gagtcctcca ggaagaagga tgaagaggaa gttcagagca agcaccggtt   2460

aatccccctc ggcagaaaaa tctatgaatt ctacaatgca cccatcgtga agttctggtt   2520

ctacacactg gcgtatatcg gatacctgat gctcttcaac tatatcgtgt tagtgaagat   2580

ggaacgctgg ccgtccaccc aggaatggat cgtaatctcc tatattttca ccctgggaat   2640

agaaaagatg agagagattc tgatgtcaga gccagggaag ttgctacaga aagtgaaggt   2700

atggctgcag gagtactgga atgtcacgga cctcatcgcc atccttctgt tttctgtcgg   2760

aatgatcctt cgtctccaag accagccctt caggagtgac gggagggtca tctactgcgt   2820

gaacatcatt tactggtata tccgtctcct agacatcttc ggcgtgaaca agtatttggg   2880

cccgtatgta atgatgattg gaaaaatgat gatagacatg atgtactttg tcatcattat   2940

gctggtggtt ctgatgagct ttggggtcgc caggcaagcc atcctttttc ccaatgagga   3000

gccatcatgg aaactggcca agaacatctt ctacatgccc tattggatga tttatgggga   3060

agtgtttgcg gaccagatag accctccctg tggacagaat gagacccgag aggatggtaa   3120

aataatccag ctgcctccct gcaagacagg agcttggatc gtgccggcca tcatggcctg   3180

ctacctctta gtggcaaaca tcttgctggt caacctcctc attgctgtct ttaacaatac   3240

attttttgaa gtaaaatcga tatccaacca agtctggaag tttcagaggt atcagctcat   3300

catgactttc catgaaaggc cagttctgcc cccaccactg atcatcttca gccacatgac   3360

catgatattc cagcacctgt gctgccgatg gaggaaacac gagagcgacc cggatgaaag   3420

ggactacggc ctgaaactct tcataaccga tgatgagctc aagaaagtac atgactttga   3480

agagcaatgc atagaagaat acttcagaga aaaggatgat cggttcaact catctaatga   3540

tgagaggata cgggtgactt cagaaagggt ggagaacatg tctatgcggc tggaggaagt   3600

caacgagaga gagcactcca tgaaggcttc actccagacc gtggacatcc ggctggcgca   3660

gctggaagac cttatcgggc gcatggccac ggccctggag cgcctgacag gtctggagcg   3720

ggccgagtcc aacaaaatcc gctcgaggac ctcgtcagac tgcacggacg ccgcctacat   3780

tgtccgtcag agcagcttca acagccagga agggaacacc ttcaagctcc aagagagtat   3840

agaccctgca ggtgaggaga ccatgtcccc aacttctcca accttaatgc cccgtatgcg   3900

aagccattct ttctattcgg tcaatatgaa agacaaaggt ggtatagaaa agttggaaag   3960

tatttttaaa gaaaggtccc tgagcctaca ccgggctact agttcccact ctgtagcaaa   4020

agaacccaaa gctcctgcag cccctgccaa caccttggcc attgttcctg attccagaag   4080

accatcatcg tgtatagaca tctatgtctc tgctatggat gagctccact gtgatataga   4140

ccctctggac aattccgtga acatccttgg gctgggcgag ccaagctttt caactccagt   4200

accttccaca gccccttcaa gtagtgccta tgcaacactt gcacccacag acagacctcc   4260

aagccggagc attgattttg aggacatcac ctccatggac actagatctt tttcttcaga   4320

ctacacccac ctcccagaat gccaaaaccc ctgggactca gagcctccga tgtaccacac   4380

cattgagcgt tccaaaagta gccgctacct agccaccaca ccctttcttc tagaagaggc   4440

tcccattgtg aaatctcata gctttatgtt ttccccctca aggagctatt atgccaactt   4500

tggggtgcct gtaaaaacag cagaatacac aagtattaca gactgtattg acacaaggtg   4560

tgtcaatgcc cctcaagcaa ttgcggacag agctgccttc cctggaggtc ttggagacaa   4620

agtggaggac ttaacttgct gccatccaga gcgagaagca gaactgagtc accccagctc   4680

tgacagtgag gagaatgagg ccaaaggccg cagagccacc attgcaatat cctcccagga   4740

gggtgataac tcagagagaa ccctgtccaa caacatcact gttcccaaga tagagcgcgc   4800

caacagctac tcggcagagg agccaagtgc gccatatgca cacaccagga agagcttctc   4860

catcagtgac aaactcgaca ggcagcggaa cacagcaagc ctgcgaaatc ccttccagag   4920

aagcaagtcc tccaagccgg agggccgagg ggacagcctg tccatgagga gactgtccag   4980

aacatcggct ttccaaagct ttgaaagcaa gcacaactaa accttcttaa tatccgccac   5040

agaaggctca agaatccagc cctaaaattc tctccaactc cagtttttcc cctttccttg   5100

aatcatacct gctttattct tagctgagca aaacaagcaa tgctttggga ggtgttaact   5160

caaaggtgac ttctgggcca cagatcaaga aagcatttga tctgacccag tgccagacac   5220

aggggattta aggcatgttc acacttgctg ggcagggagg gggaagagag ggagaaggaa   5280

gggttagaga tgaatgtgta tccgcagtca cagcagaaag ccatgagagc aggggaaaca   5340

aggggcttcg agcacgctcc atgccaggag gcatctgttg atttctgacc attatcaaga   5400

gttgtaggat gcagggctaa attgcaaaat aaaataaaat agccagcgta cacaatgaga   5460

tattctaaac ttccattctg ttttcttttc acattggctc catcactggt gactgatgaa   5520

gagcatcctc tttattcagt ataagccggc agcaagcagt tctacctaac gtcccacatc   5580

cttctcatgc caacacttct gtaattgatc attataaaga aaaaacaagg taacagtcat   5640

agttcacctg tctcttatct attcacttct ggtgccacaa ctgtttatcc ttttttgaag   5700

aaaataaggg aacagaaatg cctttttgta ttgcaatcga aatgaaagaa gagttgatgt   5760

taaaaaaaca aaagtcaagt gatttattat atacagtggg cgttcaagtc tagtcgagca   5820

agctcaggag aatgtaatta aataatttta tattttttaa tttattttgt atctcacctg   5880

tcatggatga attcattcac tgaatatgta atattgaact taaaaaaaaa aaaaaaaaaa   5940


<210>  371
<211>  1554
<212>  PRT
<213>  Homo sapiens

<400>  371


Met Tyr Val Arg Val Ser Phe Asp Thr Lys Pro Asp Leu Leu Leu His 
1               5                   10                  15      


Leu Met Thr Lys Glu Trp Gln Leu Glu Leu Pro Lys Leu Leu Ile Ser 
            20                  25                  30          


Val His Gly Gly Leu Gln Asn Phe Glu Leu Gln Pro Lys Leu Lys Gln 
        35                  40                  45              


Val Phe Gly Lys Gly Leu Ile Lys Ala Ala Met Thr Thr Gly Ala Trp 
    50                  55                  60                  


Ile Phe Thr Gly Gly Val Asn Thr Gly Val Ile Arg His Val Gly Asp 
65                  70                  75                  80  


Ala Leu Lys Asp His Ala Ser Lys Ser Arg Gly Lys Ile Cys Thr Ile 
                85                  90                  95      


Gly Ile Ala Pro Trp Gly Ile Val Glu Asn Gln Glu Asp Leu Ile Gly 
            100                 105                 110         


Arg Asp Val Val Arg Pro Tyr Gln Thr Met Ser Asn Pro Met Ser Lys 
        115                 120                 125             


Leu Thr Val Leu Asn Ser Met His Ser His Phe Ile Leu Ala Asp Asn 
    130                 135                 140                 


Gly Thr Thr Gly Lys Tyr Gly Ala Glu Val Lys Leu Arg Arg Gln Leu 
145                 150                 155                 160 


Glu Lys His Ile Ser Leu Gln Lys Ile Asn Thr Arg Ile Gly Gln Gly 
                165                 170                 175     


Val Pro Val Val Ala Leu Ile Val Glu Gly Gly Pro Asn Val Ile Ser 
            180                 185                 190         


Ile Val Leu Glu Tyr Leu Arg Asp Thr Pro Pro Val Pro Val Val Val 
        195                 200                 205             


Cys Asp Gly Ser Gly Arg Ala Ser Asp Ile Leu Ala Phe Gly His Lys 
    210                 215                 220                 


Tyr Ser Glu Glu Gly Gly Leu Ile Asn Glu Ser Leu Arg Asp Gln Leu 
225                 230                 235                 240 


Leu Val Thr Ile Gln Lys Thr Phe Thr Tyr Thr Arg Thr Gln Ala Gln 
                245                 250                 255     


His Leu Phe Ile Ile Leu Met Glu Cys Met Lys Lys Lys Glu Leu Ile 
            260                 265                 270         


Thr Val Phe Arg Met Gly Ser Glu Gly His Gln Asp Ile Asp Leu Ala 
        275                 280                 285             


Ile Leu Thr Ala Leu Leu Lys Gly Ala Asn Ala Ser Ala Pro Asp Gln 
    290                 295                 300                 


Leu Ser Leu Ala Leu Ala Trp Asn Arg Val Asp Ile Ala Arg Ser Gln 
305                 310                 315                 320 


Ile Phe Ile Tyr Gly Gln Gln Trp Pro Val Gly Ser Leu Glu Gln Ala 
                325                 330                 335     


Met Leu Asp Ala Leu Val Leu Asp Arg Val Asp Phe Val Lys Leu Leu 
            340                 345                 350         


Ile Glu Asn Gly Val Ser Met His Arg Phe Leu Thr Ile Ser Arg Leu 
        355                 360                 365             


Glu Glu Leu Tyr Asn Thr Arg His Gly Pro Ser Asn Thr Leu Tyr His 
    370                 375                 380                 


Leu Val Arg Asp Val Lys Lys Gly Asn Leu Pro Pro Asp Tyr Arg Ile 
385                 390                 395                 400 


Ser Leu Ile Asp Ile Gly Leu Val Ile Glu Tyr Leu Met Gly Gly Ala 
                405                 410                 415     


Tyr Arg Cys Asn Tyr Thr Arg Lys Arg Phe Arg Thr Leu Tyr His Asn 
            420                 425                 430         


Leu Phe Gly Pro Lys Arg Pro Lys Ala Leu Lys Leu Leu Gly Met Glu 
        435                 440                 445             


Asp Asp Ile Pro Leu Arg Arg Gly Arg Lys Thr Thr Lys Lys Arg Glu 
    450                 455                 460                 


Glu Glu Val Asp Ile Asp Leu Asp Asp Pro Glu Ile Asn His Phe Pro 
465                 470                 475                 480 


Phe Pro Phe His Glu Leu Met Val Trp Ala Val Leu Met Lys Arg Gln 
                485                 490                 495     


Lys Met Ala Leu Phe Phe Trp Gln His Gly Glu Glu Ala Met Ala Lys 
            500                 505                 510         


Ala Leu Val Ala Cys Lys Leu Cys Lys Ala Met Ala His Glu Ala Ser 
        515                 520                 525             


Glu Asn Asp Met Val Asp Asp Ile Ser Gln Glu Leu Asn His Asn Ser 
    530                 535                 540                 


Arg Asp Phe Gly Gln Leu Ala Val Glu Leu Leu Asp Gln Ser Tyr Lys 
545                 550                 555                 560 


Gln Asp Glu Gln Leu Ala Met Lys Leu Leu Thr Tyr Glu Leu Lys Asn 
                565                 570                 575     


Trp Ser Asn Ala Thr Cys Leu Gln Leu Ala Val Ala Ala Lys His Arg 
            580                 585                 590         


Asp Phe Ile Ala His Thr Cys Ser Gln Met Leu Leu Thr Asp Met Trp 
        595                 600                 605             


Met Gly Arg Leu Arg Met Arg Lys Asn Ser Gly Leu Lys Val Ile Leu 
    610                 615                 620                 


Gly Ile Leu Leu Pro Pro Ser Ile Leu Ser Leu Glu Phe Lys Asn Lys 
625                 630                 635                 640 


Asp Asp Met Pro Tyr Met Ser Gln Ala Gln Glu Ile His Leu Gln Glu 
                645                 650                 655     


Lys Glu Ala Glu Glu Pro Glu Lys Pro Thr Lys Glu Lys Glu Glu Glu 
            660                 665                 670         


Asp Met Glu Leu Thr Ala Met Leu Gly Arg Asn Asn Gly Glu Ser Ser 
        675                 680                 685             


Arg Lys Lys Asp Glu Glu Glu Val Gln Ser Lys His Arg Leu Ile Pro 
    690                 695                 700                 


Leu Gly Arg Lys Ile Tyr Glu Phe Tyr Asn Ala Pro Ile Val Lys Phe 
705                 710                 715                 720 


Trp Phe Tyr Thr Leu Ala Tyr Ile Gly Tyr Leu Met Leu Phe Asn Tyr 
                725                 730                 735     


Ile Val Leu Val Lys Met Glu Arg Trp Pro Ser Thr Gln Glu Trp Ile 
            740                 745                 750         


Val Ile Ser Tyr Ile Phe Thr Leu Gly Ile Glu Lys Met Arg Glu Ile 
        755                 760                 765             


Leu Met Ser Glu Pro Gly Lys Leu Leu Gln Lys Val Lys Val Trp Leu 
    770                 775                 780                 


Gln Glu Tyr Trp Asn Val Thr Asp Leu Ile Ala Ile Leu Leu Phe Ser 
785                 790                 795                 800 


Val Gly Met Ile Leu Arg Leu Gln Asp Gln Pro Phe Arg Ser Asp Gly 
                805                 810                 815     


Arg Val Ile Tyr Cys Val Asn Ile Ile Tyr Trp Tyr Ile Arg Leu Leu 
            820                 825                 830         


Asp Ile Phe Gly Val Asn Lys Tyr Leu Gly Pro Tyr Val Met Met Ile 
        835                 840                 845             


Gly Lys Met Met Ile Asp Met Met Tyr Phe Val Ile Ile Met Leu Val 
    850                 855                 860                 


Val Leu Met Ser Phe Gly Val Ala Arg Gln Ala Ile Leu Phe Pro Asn 
865                 870                 875                 880 


Glu Glu Pro Ser Trp Lys Leu Ala Lys Asn Ile Phe Tyr Met Pro Tyr 
                885                 890                 895     


Trp Met Ile Tyr Gly Glu Val Phe Ala Asp Gln Ile Asp Pro Pro Cys 
            900                 905                 910         


Gly Gln Asn Glu Thr Arg Glu Asp Gly Lys Ile Ile Gln Leu Pro Pro 
        915                 920                 925             


Cys Lys Thr Gly Ala Trp Ile Val Pro Ala Ile Met Ala Cys Tyr Leu 
    930                 935                 940                 


Leu Val Ala Asn Ile Leu Leu Val Asn Leu Leu Ile Ala Val Phe Asn 
945                 950                 955                 960 


Asn Thr Phe Phe Glu Val Lys Ser Ile Ser Asn Gln Val Trp Lys Phe 
                965                 970                 975     


Gln Arg Tyr Gln Leu Ile Met Thr Phe His Glu Arg Pro Val Leu Pro 
            980                 985                 990         


Pro Pro Leu Ile Ile Phe Ser His  Met Thr Met Ile Phe  Gln His Leu 
        995                 1000                 1005             


Cys Cys  Arg Trp Arg Lys His  Glu Ser Asp Pro Asp  Glu Arg Asp 
    1010                 1015                 1020             


Tyr Gly  Leu Lys Leu Phe Ile  Thr Asp Asp Glu Leu  Lys Lys Val 
    1025                 1030                 1035             


His Asp  Phe Glu Glu Gln Cys  Ile Glu Glu Tyr Phe  Arg Glu Lys 
    1040                 1045                 1050             


Asp Asp  Arg Phe Asn Ser Ser  Asn Asp Glu Arg Ile  Arg Val Thr 
    1055                 1060                 1065             


Ser Glu  Arg Val Glu Asn Met  Ser Met Arg Leu Glu  Glu Val Asn 
    1070                 1075                 1080             


Glu Arg  Glu His Ser Met Lys  Ala Ser Leu Gln Thr  Val Asp Ile 
    1085                 1090                 1095             


Arg Leu  Ala Gln Leu Glu Asp  Leu Ile Gly Arg Met  Ala Thr Ala 
    1100                 1105                 1110             


Leu Glu  Arg Leu Thr Gly Leu  Glu Arg Ala Glu Ser  Asn Lys Ile 
    1115                 1120                 1125             


Arg Ser  Arg Thr Ser Ser Asp  Cys Thr Asp Ala Ala  Tyr Ile Val 
    1130                 1135                 1140             


Arg Gln  Ser Ser Phe Asn Ser  Gln Glu Gly Asn Thr  Phe Lys Leu 
    1145                 1150                 1155             


Gln Glu  Ser Ile Asp Pro Ala  Gly Glu Glu Thr Met  Ser Pro Thr 
    1160                 1165                 1170             


Ser Pro  Thr Leu Met Pro Arg  Met Arg Ser His Ser  Phe Tyr Ser 
    1175                 1180                 1185             


Val Asn  Met Lys Asp Lys Gly  Gly Ile Glu Lys Leu  Glu Ser Ile 
    1190                 1195                 1200             


Phe Lys  Glu Arg Ser Leu Ser  Leu His Arg Ala Thr  Ser Ser His 
    1205                 1210                 1215             


Ser Val  Ala Lys Glu Pro Lys  Ala Pro Ala Ala Pro  Ala Asn Thr 
    1220                 1225                 1230             


Leu Ala  Ile Val Pro Asp Ser  Arg Arg Pro Ser Ser  Cys Ile Asp 
    1235                 1240                 1245             


Ile Tyr  Val Ser Ala Met Asp  Glu Leu His Cys Asp  Ile Asp Pro 
    1250                 1255                 1260             


Leu Asp  Asn Ser Val Asn Ile  Leu Gly Leu Gly Glu  Pro Ser Phe 
    1265                 1270                 1275             


Ser Thr  Pro Val Pro Ser Thr  Ala Pro Ser Ser Ser  Ala Tyr Ala 
    1280                 1285                 1290             


Thr Leu  Ala Pro Thr Asp Arg  Pro Pro Ser Arg Ser  Ile Asp Phe 
    1295                 1300                 1305             


Glu Asp  Ile Thr Ser Met Asp  Thr Arg Ser Phe Ser  Ser Asp Tyr 
    1310                 1315                 1320             


Thr His  Leu Pro Glu Cys Gln  Asn Pro Trp Asp Ser  Glu Pro Pro 
    1325                 1330                 1335             


Met Tyr  His Thr Ile Glu Arg  Ser Lys Ser Ser Arg  Tyr Leu Ala 
    1340                 1345                 1350             


Thr Thr  Pro Phe Leu Leu Glu  Glu Ala Pro Ile Val  Lys Ser His 
    1355                 1360                 1365             


Ser Phe  Met Phe Ser Pro Ser  Arg Ser Tyr Tyr Ala  Asn Phe Gly 
    1370                 1375                 1380             


Val Pro  Val Lys Thr Ala Glu  Tyr Thr Ser Ile Thr  Asp Cys Ile 
    1385                 1390                 1395             


Asp Thr  Arg Cys Val Asn Ala  Pro Gln Ala Ile Ala  Asp Arg Ala 
    1400                 1405                 1410             


Ala Phe  Pro Gly Gly Leu Gly  Asp Lys Val Glu Asp  Leu Thr Cys 
    1415                 1420                 1425             


Cys His  Pro Glu Arg Glu Ala  Glu Leu Ser His Pro  Ser Ser Asp 
    1430                 1435                 1440             


Ser Glu  Glu Asn Glu Ala Lys  Gly Arg Arg Ala Thr  Ile Ala Ile 
    1445                 1450                 1455             


Ser Ser  Gln Glu Gly Asp Asn  Ser Glu Arg Thr Leu  Ser Asn Asn 
    1460                 1465                 1470             


Ile Thr  Val Pro Lys Ile Glu  Arg Ala Asn Ser Tyr  Ser Ala Glu 
    1475                 1480                 1485             


Glu Pro  Ser Ala Pro Tyr Ala  His Thr Arg Lys Ser  Phe Ser Ile 
    1490                 1495                 1500             


Ser Asp  Lys Leu Asp Arg Gln  Arg Asn Thr Ala Ser  Leu Arg Asn 
    1505                 1510                 1515             


Pro Phe  Gln Arg Ser Lys Ser  Ser Lys Pro Glu Gly  Arg Gly Asp 
    1520                 1525                 1530             


Ser Leu  Ser Met Arg Arg Leu  Ser Arg Thr Ser Ala  Phe Gln Ser 
    1535                 1540                 1545             


Phe Glu  Ser Lys His Asn 
    1550                 

<210>  372
<211>  5976
<212>  DNA
<213>  Homo sapiens

<400>  372
agctgcagca aaatgaaagc aacaggagct gctccgggga ctgcttttgc cagtacccag     60

aatcagtgct caggctcaga aatcctggat agaaagagca ttttataaaa gagaatgtgt    120

ccacatcata cccagcacca aagaccccca taggtgttgc tgtgggcgtc tgataggcca    180

gcatgttggc ctcaccccca gtatctccgt gcttcagaat gagaaaaatg aaagtcgcct    240

ctcccgaaat gacatccagt ctgaaaagtg gtccatcagc aaacacactc aactcagccc    300

tacggatgct tttgggacca ttgagttcca aggaggtggc cattccaaca aagccatgta    360

tgtgcgagta tcttttgata caaaacctga tctcctctta cacctgatga ccaaggaatg    420

gcagttggag cttcccaagc ttctcatctc tgtccatggg ggcctgcaga actttgaact    480

ccagccaaaa ctcaagcaag tctttgggaa agggctcatc aaagcagcaa tgacaactgg    540

agcgtggata ttcactggag gggttaacac aggtgttatt cgtcatgttg gcgatgcctt    600

gaaggatcat gcctctaagt ctcgaggaaa gatatgcacc ataggtattg ccccctgggg    660

aattgtggaa aaccaggagg acctcattgg aagagatgtt gtccggccat accagaccat    720

gtccaatccc atgagcaagc tcactgttct caacagcatg cattcccact tcattctggc    780

tgacaacggg accactggaa aatatggagc agaggtgaaa cttcgaagac aactggaaaa    840

gcatatttca ctccagaaga taaacacaag aatcggtcaa ggtgttcctg tggtggcact    900

catagtggaa ggaggaccca atgtgatctc gattgttttg gagtaccttc gagacacccc    960

tcccgtgcca gtggttgtct gtgatgggag tggacgggca tcggacatcc tggcctttgg   1020

gcataaatac tcagaagaag gcggactgat aaatgaatct ttgagggacc agctgttggt   1080

gactatacag aagactttca catacactcg aacccaagct cagcatctgt tcatcatcct   1140

catggagtgc atgaagaaga aggaattgat tacggtattt cggatgggat cagaaggaca   1200

ccaggacatt gatttggcta tcctgacagc tttactcaaa ggagccaatg cctcggcccc   1260

agaccaactg agcttagctt tagcctggaa cagagtcgac atcgctcgca gccagatctt   1320

tatttacggg caacagtggc cggtgggatc tctggagcaa gccatgttgg atgccttagt   1380

tctggacaga gtggattttg tgaaattact catagagaat ggagtaagca tgcaccgttt   1440

tctcaccatc tccagactag aggaattgta caatacgaga catgggccct caaatacatt   1500

gtaccacttg gtcagggatg tcaaaaagcg agagtatcca ggtttcggtt ggatctattt   1560

taaggggaac ctgcccccag actacagaat cagcctgatt gacatcggcc tggtgatcga   1620

gtacctgatg ggcggggctt atcgctgcaa ctacacgcgc aagcgcttcc ggaccctcta   1680

ccacaacctc ttcggcccca agaggcccaa agccttgaaa ctgctgggaa tggaggatga   1740

tattcccttg aggcgaggaa gaaagacaac caagaaacgt gaagaagagg tggacattga   1800

cttggatgat cctgagatca accacttccc cttccctttc catgagctca tggtgtgggc   1860

tgttctcatg aagcggcaga agatggccct gttcttctgg cagcacggtg aggaggccat   1920

ggccaaggcc ctggtggcct gcaagctctg caaagccatg gctcatgagg cctctgagaa   1980

cgacatggtt gacgacattt cccaggagct gaatcacaat tccagagact ttggccagct   2040

ggctgtggag ctcctggacc agtcctacaa gcaggacgaa cagctggcca tgaaactgct   2100

gacgtatgag ctgaagaact ggagcaacgc cacgtgcctg cagcttgccg tggctgccaa   2160

acaccgcgac ttcatcgcgc acacgtgcag ccagatgctg ctcaccgaca tgtggatggg   2220

ccggctccgc atgcgcaaga actcaggcct caaggtaatt ctgggaattc tacttcctcc   2280

ttcaattctc agcttggagt tcaagaacaa agacgacatg ccctatatgt ctcaggccca   2340

ggaaatccac ctccaagaga aggaggcaga agaaccagag aagcccacaa aggaaaaaga   2400

ggaagaggac atggagctca cagcaatgtt gggacgaaac aacggggagt cctccaggaa   2460

gaaggatgaa gaggaagttc agagcaagca ccggttaatc cccctcggca gaaaaatcta   2520

tgaattctac aatgcaccca tcgtgaagtt ctggttctac acactggcgt atatcggata   2580

cctgatgctc ttcaactata tcgtgttagt gaagatggaa cgctggccgt ccacccagga   2640

atggatcgta atctcctata ttttcaccct gggaatagaa aagatgagag agattctgat   2700

gtcagagcca gggaagttgc tacagaaagt gaaggtatgg ctgcaggagt actggaatgt   2760

cacggacctc atcgccatcc ttctgttttc tgtcggaatg atccttcgtc tccaagacca   2820

gcccttcagg agtgacggga gggtcatcta ctgcgtgaac atcatttact ggtatatccg   2880

tctcctagac atcttcggcg tgaacaagta tttgggcccg tatgtaatga tgattggaaa   2940

aatgatgata gacatgatgt actttgtcat cattatgctg gtggttctga tgagctttgg   3000

ggtcgccagg caagccatcc tttttcccaa tgaggagcca tcatggaaac tggccaagaa   3060

catcttctac atgccctatt ggatgattta tggggaagtg tttgcggacc agatagaccc   3120

tccctgtgga cagaatgaga cccgagagga tggtaaaata atccagctgc ctccctgcaa   3180

gacaggagct tggatcgtgc cggccatcat ggcctgctac ctcttagtgg caaacatctt   3240

gctggtcaac ctcctcattg ctgtctttaa caatacattt tttgaagtaa aatcgatatc   3300

caaccaagtc tggaagtttc agaggtatca gctcatcatg actttccatg aaaggccagt   3360

tctgccccca ccactgatca tcttcagcca catgaccatg atattccagc acctgtgctg   3420

ccgatggagg aaacacgaga gcgacccgga tgaaagggac tacggcctga aactcttcat   3480

aaccgatgat gagctcaaga aagtacatga ctttgaagag caatgcatag aagaatactt   3540

cagagaaaag gatgatcggt tcaactcatc taatgatgag aggatacggg tgacttcaga   3600

aagggtggag aacatgtcta tgcggctgga ggaagtcaac gagagagagc actccatgaa   3660

ggcttcactc cagaccgtgg acatccggct ggcgcagctg gaagacctta tcgggcgcat   3720

ggccacggcc ctggagcgcc tgacaggtct ggagcgggcc gagtccaaca aaatccgctc   3780

gaggacctcg tcagactgca cggacgccgc ctacattgtc cgtcagagca gcttcaacag   3840

ccaggaaggg aacaccttca agctccaaga gagtatagac cctgcaggtg aggagaccat   3900

gtccccaact tctccaacct taatgccccg tatgcgaagc cattctttct attcggtcaa   3960

tatgaaagac aaaggtggta tagaaaagtt ggaaagtatt tttaaagaaa ggtccctgag   4020

cctacaccgg gctactagtt cccactctgt agcaaaagaa cccaaagctc ctgcagcccc   4080

tgccaacacc ttggccattg ttcctgattc cagaagacca tcatcgtgta tagacatcta   4140

tgtctctgct atggatgagc tccactgtga tatagaccct ctggacaatt ccgtgaacat   4200

ccttgggctg ggcgagccaa gcttttcaac tccagtacct tccacagccc cttcaagtag   4260

tgcctatgca acacttgcac ccacagacag acctccaagc cggagcattg attttgagga   4320

catcacctcc atggacacta gatctttttc ttcagactac acccacctcc cagaatgcca   4380

aaacccctgg gactcagagc ctccgatgta ccacaccatt gagcgttcca aaagtagccg   4440

ctacctagcc accacaccct ttcttctaga agaggctccc attgtgaaat ctcatagctt   4500

tatgttttcc ccctcaagga gctattatgc caactttggg gtgcctgtaa aaacagcaga   4560

atacacaagt attacagact gtattgacac aaggtgtgtc aatgcccctc aagcaattgc   4620

ggacagagct gccttccctg gaggtcttgg agacaaagtg gaggacttaa cttgctgcca   4680

tccagagcga gaagcagaac tgagtcaccc cagctctgac agtgaggaga atgaggccaa   4740

aggccgcaga gccaccattg caatatcctc ccaggagggt gataactcag agagaaccct   4800

gtccaacaac atcactgttc ccaagataga gcgcgccaac agctactcgg cagaggagcc   4860

aagtgcgcca tatgcacaca ccaggaagag cttctccatc agtgacaaac tcgacaggca   4920

gcggaacaca gcaagcctgc gaaatccctt ccagagaagc aagtcctcca agccggaggg   4980

ccgaggggac agcctgtcca tgaggagact gtccagaaca tcggctttcc aaagctttga   5040

aagcaagcac aactaaacct tcttaatatc cgccacagaa ggctcaagaa tccagcccta   5100

aaattctctc caactccagt ttttcccctt tccttgaatc atacctgctt tattcttagc   5160

tgagcaaaac aagcaatgct ttgggaggtg ttaactcaaa ggtgacttct gggccacaga   5220

tcaagaaagc atttgatctg acccagtgcc agacacaggg gatttaaggc atgttcacac   5280

ttgctgggca gggaggggga agagagggag aaggaagggt tagagatgaa tgtgtatccg   5340

cagtcacagc agaaagccat gagagcaggg gaaacaaggg gcttcgagca cgctccatgc   5400

caggaggcat ctgttgattt ctgaccatta tcaagagttg taggatgcag ggctaaattg   5460

caaaataaaa taaaatagcc agcgtacaca atgagatatt ctaaacttcc attctgtttt   5520

cttttcacat tggctccatc actggtgact gatgaagagc atcctcttta ttcagtataa   5580

gccggcagca agcagttcta cctaacgtcc cacatccttc tcatgccaac acttctgtaa   5640

ttgatcatta taaagaaaaa acaaggtaac agtcatagtt cacctgtctc ttatctattc   5700

acttctggtg ccacaactgt ttatcctttt ttgaagaaaa taagggaaca gaaatgcctt   5760

tttgtattgc aatcgaaatg aaagaagagt tgatgttaaa aaaacaaaag tcaagtgatt   5820

tattatatac agtgggcgtt caagtctagt cgagcaagct caggagaatg taattaaata   5880

attttatatt ttttaattta ttttgtatct cacctgtcat ggatgaattc attcactgaa   5940

tatgtaatat tgaacttaaa aaaaaaaaaa aaaaaa                             5976


<210>  373
<211>  1566
<212>  PRT
<213>  Homo sapiens

<400>  373


Met Tyr Val Arg Val Ser Phe Asp Thr Lys Pro Asp Leu Leu Leu His 
1               5                   10                  15      


Leu Met Thr Lys Glu Trp Gln Leu Glu Leu Pro Lys Leu Leu Ile Ser 
            20                  25                  30          


Val His Gly Gly Leu Gln Asn Phe Glu Leu Gln Pro Lys Leu Lys Gln 
        35                  40                  45              


Val Phe Gly Lys Gly Leu Ile Lys Ala Ala Met Thr Thr Gly Ala Trp 
    50                  55                  60                  


Ile Phe Thr Gly Gly Val Asn Thr Gly Val Ile Arg His Val Gly Asp 
65                  70                  75                  80  


Ala Leu Lys Asp His Ala Ser Lys Ser Arg Gly Lys Ile Cys Thr Ile 
                85                  90                  95      


Gly Ile Ala Pro Trp Gly Ile Val Glu Asn Gln Glu Asp Leu Ile Gly 
            100                 105                 110         


Arg Asp Val Val Arg Pro Tyr Gln Thr Met Ser Asn Pro Met Ser Lys 
        115                 120                 125             


Leu Thr Val Leu Asn Ser Met His Ser His Phe Ile Leu Ala Asp Asn 
    130                 135                 140                 


Gly Thr Thr Gly Lys Tyr Gly Ala Glu Val Lys Leu Arg Arg Gln Leu 
145                 150                 155                 160 


Glu Lys His Ile Ser Leu Gln Lys Ile Asn Thr Arg Ile Gly Gln Gly 
                165                 170                 175     


Val Pro Val Val Ala Leu Ile Val Glu Gly Gly Pro Asn Val Ile Ser 
            180                 185                 190         


Ile Val Leu Glu Tyr Leu Arg Asp Thr Pro Pro Val Pro Val Val Val 
        195                 200                 205             


Cys Asp Gly Ser Gly Arg Ala Ser Asp Ile Leu Ala Phe Gly His Lys 
    210                 215                 220                 


Tyr Ser Glu Glu Gly Gly Leu Ile Asn Glu Ser Leu Arg Asp Gln Leu 
225                 230                 235                 240 


Leu Val Thr Ile Gln Lys Thr Phe Thr Tyr Thr Arg Thr Gln Ala Gln 
                245                 250                 255     


His Leu Phe Ile Ile Leu Met Glu Cys Met Lys Lys Lys Glu Leu Ile 
            260                 265                 270         


Thr Val Phe Arg Met Gly Ser Glu Gly His Gln Asp Ile Asp Leu Ala 
        275                 280                 285             


Ile Leu Thr Ala Leu Leu Lys Gly Ala Asn Ala Ser Ala Pro Asp Gln 
    290                 295                 300                 


Leu Ser Leu Ala Leu Ala Trp Asn Arg Val Asp Ile Ala Arg Ser Gln 
305                 310                 315                 320 


Ile Phe Ile Tyr Gly Gln Gln Trp Pro Val Gly Ser Leu Glu Gln Ala 
                325                 330                 335     


Met Leu Asp Ala Leu Val Leu Asp Arg Val Asp Phe Val Lys Leu Leu 
            340                 345                 350         


Ile Glu Asn Gly Val Ser Met His Arg Phe Leu Thr Ile Ser Arg Leu 
        355                 360                 365             


Glu Glu Leu Tyr Asn Thr Arg His Gly Pro Ser Asn Thr Leu Tyr His 
    370                 375                 380                 


Leu Val Arg Asp Val Lys Lys Arg Glu Tyr Pro Gly Phe Gly Trp Ile 
385                 390                 395                 400 


Tyr Phe Lys Gly Asn Leu Pro Pro Asp Tyr Arg Ile Ser Leu Ile Asp 
                405                 410                 415     


Ile Gly Leu Val Ile Glu Tyr Leu Met Gly Gly Ala Tyr Arg Cys Asn 
            420                 425                 430         


Tyr Thr Arg Lys Arg Phe Arg Thr Leu Tyr His Asn Leu Phe Gly Pro 
        435                 440                 445             


Lys Arg Pro Lys Ala Leu Lys Leu Leu Gly Met Glu Asp Asp Ile Pro 
    450                 455                 460                 


Leu Arg Arg Gly Arg Lys Thr Thr Lys Lys Arg Glu Glu Glu Val Asp 
465                 470                 475                 480 


Ile Asp Leu Asp Asp Pro Glu Ile Asn His Phe Pro Phe Pro Phe His 
                485                 490                 495     


Glu Leu Met Val Trp Ala Val Leu Met Lys Arg Gln Lys Met Ala Leu 
            500                 505                 510         


Phe Phe Trp Gln His Gly Glu Glu Ala Met Ala Lys Ala Leu Val Ala 
        515                 520                 525             


Cys Lys Leu Cys Lys Ala Met Ala His Glu Ala Ser Glu Asn Asp Met 
    530                 535                 540                 


Val Asp Asp Ile Ser Gln Glu Leu Asn His Asn Ser Arg Asp Phe Gly 
545                 550                 555                 560 


Gln Leu Ala Val Glu Leu Leu Asp Gln Ser Tyr Lys Gln Asp Glu Gln 
                565                 570                 575     


Leu Ala Met Lys Leu Leu Thr Tyr Glu Leu Lys Asn Trp Ser Asn Ala 
            580                 585                 590         


Thr Cys Leu Gln Leu Ala Val Ala Ala Lys His Arg Asp Phe Ile Ala 
        595                 600                 605             


His Thr Cys Ser Gln Met Leu Leu Thr Asp Met Trp Met Gly Arg Leu 
    610                 615                 620                 


Arg Met Arg Lys Asn Ser Gly Leu Lys Val Ile Leu Gly Ile Leu Leu 
625                 630                 635                 640 


Pro Pro Ser Ile Leu Ser Leu Glu Phe Lys Asn Lys Asp Asp Met Pro 
                645                 650                 655     


Tyr Met Ser Gln Ala Gln Glu Ile His Leu Gln Glu Lys Glu Ala Glu 
            660                 665                 670         


Glu Pro Glu Lys Pro Thr Lys Glu Lys Glu Glu Glu Asp Met Glu Leu 
        675                 680                 685             


Thr Ala Met Leu Gly Arg Asn Asn Gly Glu Ser Ser Arg Lys Lys Asp 
    690                 695                 700                 


Glu Glu Glu Val Gln Ser Lys His Arg Leu Ile Pro Leu Gly Arg Lys 
705                 710                 715                 720 


Ile Tyr Glu Phe Tyr Asn Ala Pro Ile Val Lys Phe Trp Phe Tyr Thr 
                725                 730                 735     


Leu Ala Tyr Ile Gly Tyr Leu Met Leu Phe Asn Tyr Ile Val Leu Val 
            740                 745                 750         


Lys Met Glu Arg Trp Pro Ser Thr Gln Glu Trp Ile Val Ile Ser Tyr 
        755                 760                 765             


Ile Phe Thr Leu Gly Ile Glu Lys Met Arg Glu Ile Leu Met Ser Glu 
    770                 775                 780                 


Pro Gly Lys Leu Leu Gln Lys Val Lys Val Trp Leu Gln Glu Tyr Trp 
785                 790                 795                 800 


Asn Val Thr Asp Leu Ile Ala Ile Leu Leu Phe Ser Val Gly Met Ile 
                805                 810                 815     


Leu Arg Leu Gln Asp Gln Pro Phe Arg Ser Asp Gly Arg Val Ile Tyr 
            820                 825                 830         


Cys Val Asn Ile Ile Tyr Trp Tyr Ile Arg Leu Leu Asp Ile Phe Gly 
        835                 840                 845             


Val Asn Lys Tyr Leu Gly Pro Tyr Val Met Met Ile Gly Lys Met Met 
    850                 855                 860                 


Ile Asp Met Met Tyr Phe Val Ile Ile Met Leu Val Val Leu Met Ser 
865                 870                 875                 880 


Phe Gly Val Ala Arg Gln Ala Ile Leu Phe Pro Asn Glu Glu Pro Ser 
                885                 890                 895     


Trp Lys Leu Ala Lys Asn Ile Phe Tyr Met Pro Tyr Trp Met Ile Tyr 
            900                 905                 910         


Gly Glu Val Phe Ala Asp Gln Ile Asp Pro Pro Cys Gly Gln Asn Glu 
        915                 920                 925             


Thr Arg Glu Asp Gly Lys Ile Ile Gln Leu Pro Pro Cys Lys Thr Gly 
    930                 935                 940                 


Ala Trp Ile Val Pro Ala Ile Met Ala Cys Tyr Leu Leu Val Ala Asn 
945                 950                 955                 960 


Ile Leu Leu Val Asn Leu Leu Ile Ala Val Phe Asn Asn Thr Phe Phe 
                965                 970                 975     


Glu Val Lys Ser Ile Ser Asn Gln Val Trp Lys Phe Gln Arg Tyr Gln 
            980                 985                 990         


Leu Ile Met Thr Phe His Glu Arg  Pro Val Leu Pro Pro  Pro Leu Ile 
        995                 1000                 1005             


Ile Phe  Ser His Met Thr Met  Ile Phe Gln His Leu  Cys Cys Arg 
    1010                 1015                 1020             


Trp Arg  Lys His Glu Ser Asp  Pro Asp Glu Arg Asp  Tyr Gly Leu 
    1025                 1030                 1035             


Lys Leu  Phe Ile Thr Asp Asp  Glu Leu Lys Lys Val  His Asp Phe 
    1040                 1045                 1050             


Glu Glu  Gln Cys Ile Glu Glu  Tyr Phe Arg Glu Lys  Asp Asp Arg 
    1055                 1060                 1065             


Phe Asn  Ser Ser Asn Asp Glu  Arg Ile Arg Val Thr  Ser Glu Arg 
    1070                 1075                 1080             


Val Glu  Asn Met Ser Met Arg  Leu Glu Glu Val Asn  Glu Arg Glu 
    1085                 1090                 1095             


His Ser  Met Lys Ala Ser Leu  Gln Thr Val Asp Ile  Arg Leu Ala 
    1100                 1105                 1110             


Gln Leu  Glu Asp Leu Ile Gly  Arg Met Ala Thr Ala  Leu Glu Arg 
    1115                 1120                 1125             


Leu Thr  Gly Leu Glu Arg Ala  Glu Ser Asn Lys Ile  Arg Ser Arg 
    1130                 1135                 1140             


Thr Ser  Ser Asp Cys Thr Asp  Ala Ala Tyr Ile Val  Arg Gln Ser 
    1145                 1150                 1155             


Ser Phe  Asn Ser Gln Glu Gly  Asn Thr Phe Lys Leu  Gln Glu Ser 
    1160                 1165                 1170             


Ile Asp  Pro Ala Gly Glu Glu  Thr Met Ser Pro Thr  Ser Pro Thr 
    1175                 1180                 1185             


Leu Met  Pro Arg Met Arg Ser  His Ser Phe Tyr Ser  Val Asn Met 
    1190                 1195                 1200             


Lys Asp  Lys Gly Gly Ile Glu  Lys Leu Glu Ser Ile  Phe Lys Glu 
    1205                 1210                 1215             


Arg Ser  Leu Ser Leu His Arg  Ala Thr Ser Ser His  Ser Val Ala 
    1220                 1225                 1230             


Lys Glu  Pro Lys Ala Pro Ala  Ala Pro Ala Asn Thr  Leu Ala Ile 
    1235                 1240                 1245             


Val Pro  Asp Ser Arg Arg Pro  Ser Ser Cys Ile Asp  Ile Tyr Val 
    1250                 1255                 1260             


Ser Ala  Met Asp Glu Leu His  Cys Asp Ile Asp Pro  Leu Asp Asn 
    1265                 1270                 1275             


Ser Val  Asn Ile Leu Gly Leu  Gly Glu Pro Ser Phe  Ser Thr Pro 
    1280                 1285                 1290             


Val Pro  Ser Thr Ala Pro Ser  Ser Ser Ala Tyr Ala  Thr Leu Ala 
    1295                 1300                 1305             


Pro Thr  Asp Arg Pro Pro Ser  Arg Ser Ile Asp Phe  Glu Asp Ile 
    1310                 1315                 1320             


Thr Ser  Met Asp Thr Arg Ser  Phe Ser Ser Asp Tyr  Thr His Leu 
    1325                 1330                 1335             


Pro Glu  Cys Gln Asn Pro Trp  Asp Ser Glu Pro Pro  Met Tyr His 
    1340                 1345                 1350             


Thr Ile  Glu Arg Ser Lys Ser  Ser Arg Tyr Leu Ala  Thr Thr Pro 
    1355                 1360                 1365             


Phe Leu  Leu Glu Glu Ala Pro  Ile Val Lys Ser His  Ser Phe Met 
    1370                 1375                 1380             


Phe Ser  Pro Ser Arg Ser Tyr  Tyr Ala Asn Phe Gly  Val Pro Val 
    1385                 1390                 1395             


Lys Thr  Ala Glu Tyr Thr Ser  Ile Thr Asp Cys Ile  Asp Thr Arg 
    1400                 1405                 1410             


Cys Val  Asn Ala Pro Gln Ala  Ile Ala Asp Arg Ala  Ala Phe Pro 
    1415                 1420                 1425             


Gly Gly  Leu Gly Asp Lys Val  Glu Asp Leu Thr Cys  Cys His Pro 
    1430                 1435                 1440             


Glu Arg  Glu Ala Glu Leu Ser  His Pro Ser Ser Asp  Ser Glu Glu 
    1445                 1450                 1455             


Asn Glu  Ala Lys Gly Arg Arg  Ala Thr Ile Ala Ile  Ser Ser Gln 
    1460                 1465                 1470             


Glu Gly  Asp Asn Ser Glu Arg  Thr Leu Ser Asn Asn  Ile Thr Val 
    1475                 1480                 1485             


Pro Lys  Ile Glu Arg Ala Asn  Ser Tyr Ser Ala Glu  Glu Pro Ser 
    1490                 1495                 1500             


Ala Pro  Tyr Ala His Thr Arg  Lys Ser Phe Ser Ile  Ser Asp Lys 
    1505                 1510                 1515             


Leu Asp  Arg Gln Arg Asn Thr  Ala Ser Leu Arg Asn  Pro Phe Gln 
    1520                 1525                 1530             


Arg Ser  Lys Ser Ser Lys Pro  Glu Gly Arg Gly Asp  Ser Leu Ser 
    1535                 1540                 1545             


Met Arg  Arg Leu Ser Arg Thr  Ser Ala Phe Gln Ser  Phe Glu Ser 
    1550                 1555                 1560             


Lys His  Asn 
    1565     

<210>  374
<211>  5910
<212>  DNA
<213>  Homo sapiens

<400>  374
agctgcagca aaatgaaagc aacaggagct gctccgggga ctgcttttgc cagtacccag     60

aatcagtgct caggctcaga aatcctggat agaaagagca ttttataaaa gagaatgtgt    120

ccacatcata cccagcacca aagaccccca taggtgttgc tgtgggcgtc tgataggcca    180

gcatgttggc ctcaccccca gtatctccgt gcttcagaat gagaaaaatg aaagtcgcct    240

ctcccgaaat gacatccagt ctgaaaagtg gtccatcagc aaacacactc aactcagccc    300

tacggatgct tttgggacca ttgagttcca aggaggtggc cattccaaca aagccatgta    360

tgtgcgagta tcttttgata caaaacctga tctcctctta cacctgatga ccaaggaatg    420

gcagttggag cttcccaagc ttctcatctc tgtccatggg ggcctgcaga actttgaact    480

ccagccaaaa ctcaagcaag tctttgggaa agggctcatc aaagcagcaa tgacaactgg    540

agcgtggata ttcactggag gggttaacac aggtgttatt cgtcatgttg gcgatgcctt    600

gaaggatcat gcctctaagt ctcgaggaaa gatatgcacc ataggtattg ccccctgggg    660

aattgtggaa aaccaggagg acctcattgg aagagatgtt gtccggccat accagaccat    720

gtccaatccc atgagcaagc tcactgttct caacagcatg cattcccact tcattctggc    780

tgacaacggg accactggaa aatatggagc agaggtgaaa cttcgaagac aactggaaaa    840

gcatatttca ctccagaaga taaacacaag aatcggtcaa ggtgttcctg tggtggcact    900

catagtggaa ggaggaccca atgtgatctc gattgttttg gagtaccttc gagacacccc    960

tcccgtgcca gtggttgtct gtgatgggag tggacgggca tcggacatcc tggcctttgg   1020

gcataaatac tcagaagaag gcggactgat aaatgaatct ttgagggacc agctgttggt   1080

gactatacag aagactttca catacactcg aacccaagct cagcatctgt tcatcatcct   1140

catggagtgc atgaagaaga aggaattgat tacggtattt cggatgggat cagaaggaca   1200

ccaggacatt gatttggcta tcctgacagc tttactcaaa ggagccaatg cctcggcccc   1260

agaccaactg agcttagctt tagcctggaa cagagtcgac atcgctcgca gccagatctt   1320

tatttacggg caacagtggc cggtgggatc tctggagcaa gccatgttgg atgccttagt   1380

tctggacaga gtggattttg tgaaattact catagagaat ggagtaagca tgcaccgttt   1440

tctcaccatc tccagactag aggaattgta caatacgaga catgggccct caaatacatt   1500

gtaccacttg gtcagggatg tcaaaaaggg gaacctgccc ccagactaca gaatcagcct   1560

gattgacatc ggcctggtga tcgagtacct gatgggcggg gcttatcgct gcaactacac   1620

gcgcaagcgc ttccggaccc tctaccacaa cctcttcggc cccaagaggg atgatattcc   1680

cttgaggcga ggaagaaaga caaccaagaa acgtgaagaa gaggtggaca ttgacttgga   1740

tgatcctgag atcaaccact tccccttccc tttccatgag ctcatggtgt gggctgttct   1800

catgaagcgg cagaagatgg ccctgttctt ctggcagcac ggtgaggagg ccatggccaa   1860

ggccctggtg gcctgcaagc tctgcaaagc catggctcat gaggcctctg agaacgacat   1920

ggttgacgac atttcccagg agctgaatca caattccaga gactttggcc agctggctgt   1980

ggagctcctg gaccagtcct acaagcagga cgaacagctg gccatgaaac tgctgacgta   2040

tgagctgaag aactggagca acgccacgtg cctgcagctt gccgtggctg ccaaacaccg   2100

cgacttcatc gcgcacacgt gcagccagat gctgctcacc gacatgtgga tgggccggct   2160

ccgcatgcgc aagaactcag gcctcaaggt aattctggga attctacttc ctccttcaat   2220

tctcagcttg gagttcaaga acaaagacga catgccctat atgtctcagg cccaggaaat   2280

ccacctccaa gagaaggagg cagaagaacc agagaagccc acaaaggaaa aagaggaaga   2340

ggacatggag ctcacagcaa tgttgggacg aaacaacggg gagtcctcca ggaagaagga   2400

tgaagaggaa gttcagagca agcaccggtt aatccccctc ggcagaaaaa tctatgaatt   2460

ctacaatgca cccatcgtga agttctggtt ctacacactg gcgtatatcg gatacctgat   2520

gctcttcaac tatatcgtgt tagtgaagat ggaacgctgg ccgtccaccc aggaatggat   2580

cgtaatctcc tatattttca ccctgggaat agaaaagatg agagagattc tgatgtcaga   2640

gccagggaag ttgctacaga aagtgaaggt atggctgcag gagtactgga atgtcacgga   2700

cctcatcgcc atccttctgt tttctgtcgg aatgatcctt cgtctccaag accagccctt   2760

caggagtgac gggagggtca tctactgcgt gaacatcatt tactggtata tccgtctcct   2820

agacatcttc ggcgtgaaca agtatttggg cccgtatgta atgatgattg gaaaaatgat   2880

gatagacatg atgtactttg tcatcattat gctggtggtt ctgatgagct ttggggtcgc   2940

caggcaagcc atcctttttc ccaatgagga gccatcatgg aaactggcca agaacatctt   3000

ctacatgccc tattggatga tttatgggga agtgtttgcg gaccagatag accctccctg   3060

tggacagaat gagacccgag aggatggtaa aataatccag ctgcctccct gcaagacagg   3120

agcttggatc gtgccggcca tcatggcctg ctacctctta gtggcaaaca tcttgctggt   3180

caacctcctc attgctgtct ttaacaatac attttttgaa gtaaaatcga tatccaacca   3240

agtctggaag tttcagaggt atcagctcat catgactttc catgaaaggc cagttctgcc   3300

cccaccactg atcatcttca gccacatgac catgatattc cagcacctgt gctgccgatg   3360

gaggaaacac gagagcgacc cggatgaaag ggactacggc ctgaaactct tcataaccga   3420

tgatgagctc aagaaagtac atgactttga agagcaatgc atagaagaat acttcagaga   3480

aaaggatgat cggttcaact catctaatga tgagaggata cgggtgactt cagaaagggt   3540

ggagaacatg tctatgcggc tggaggaagt caacgagaga gagcactcca tgaaggcttc   3600

actccagacc gtggacatcc ggctggcgca gctggaagac cttatcgggc gcatggccac   3660

ggccctggag cgcctgacag gtctggagcg ggccgagtcc aacaaaatcc gctcgaggac   3720

ctcgtcagac tgcacggacg ccgcctacat tgtccgtcag agcagcttca acagccagga   3780

agggaacacc ttcaagctcc aagagagtat agaccctgca ggtgaggaga ccatgtcccc   3840

aacttctcca accttaatgc cccgtatgcg aagccattct ttctattcgg tcaatatgaa   3900

agacaaaggt ggtatagaaa agttggaaag tatttttaaa gaaaggtccc tgagcctaca   3960

ccgggctact agttcccact ctgtagcaaa agaacccaaa gctcctgcag cccctgccaa   4020

caccttggcc attgttcctg attccagaag accatcatcg tgtatagaca tctatgtctc   4080

tgctatggat gagctccact gtgatataga ccctctggac aattccgtga acatccttgg   4140

gctgggcgag ccaagctttt caactccagt accttccaca gccccttcaa gtagtgccta   4200

tgcaacactt gcacccacag acagacctcc aagccggagc attgattttg aggacatcac   4260

ctccatggac actagatctt tttcttcaga ctacacccac ctcccagaat gccaaaaccc   4320

ctgggactca gagcctccga tgtaccacac cattgagcgt tccaaaagta gccgctacct   4380

agccaccaca ccctttcttc tagaagaggc tcccattgtg aaatctcata gctttatgtt   4440

ttccccctca aggagctatt atgccaactt tggggtgcct gtaaaaacag cagaatacac   4500

aagtattaca gactgtattg acacaaggtg tgtcaatgcc cctcaagcaa ttgcggacag   4560

agctgccttc cctggaggtc ttggagacaa agtggaggac ttaacttgct gccatccaga   4620

gcgagaagca gaactgagtc accccagctc tgacagtgag gagaatgagg ccaaaggccg   4680

cagagccacc attgcaatat cctcccagga gggtgataac tcagagagaa ccctgtccaa   4740

caacatcact gttcccaaga tagagcgcgc caacagctac tcggcagagg agccaagtgc   4800

gccatatgca cacaccagga agagcttctc catcagtgac aaactcgaca ggcagcggaa   4860

cacagcaagc ctgcgaaatc ccttccagag aagcaagtcc tccaagccgg agggccgagg   4920

ggacagcctg tccatgagga gactgtccag aacatcggct ttccaaagct ttgaaagcaa   4980

gcacaactaa accttcttaa tatccgccac agaaggctca agaatccagc cctaaaattc   5040

tctccaactc cagtttttcc cctttccttg aatcatacct gctttattct tagctgagca   5100

aaacaagcaa tgctttggga ggtgttaact caaaggtgac ttctgggcca cagatcaaga   5160

aagcatttga tctgacccag tgccagacac aggggattta aggcatgttc acacttgctg   5220

ggcagggagg gggaagagag ggagaaggaa gggttagaga tgaatgtgta tccgcagtca   5280

cagcagaaag ccatgagagc aggggaaaca aggggcttcg agcacgctcc atgccaggag   5340

gcatctgttg atttctgacc attatcaaga gttgtaggat gcagggctaa attgcaaaat   5400

aaaataaaat agccagcgta cacaatgaga tattctaaac ttccattctg ttttcttttc   5460

acattggctc catcactggt gactgatgaa gagcatcctc tttattcagt ataagccggc   5520

agcaagcagt tctacctaac gtcccacatc cttctcatgc caacacttct gtaattgatc   5580

attataaaga aaaaacaagg taacagtcat agttcacctg tctcttatct attcacttct   5640

ggtgccacaa ctgtttatcc ttttttgaag aaaataaggg aacagaaatg cctttttgta   5700

ttgcaatcga aatgaaagaa gagttgatgt taaaaaaaca aaagtcaagt gatttattat   5760

atacagtggg cgttcaagtc tagtcgagca agctcaggag aatgtaatta aataatttta   5820

tattttttaa tttattttgt atctcacctg tcatggatga attcattcac tgaatatgta   5880

atattgaact taaaaaaaaa aaaaaaaaaa                                    5910


<210>  375
<211>  1544
<212>  PRT
<213>  Homo sapiens

<400>  375


Met Tyr Val Arg Val Ser Phe Asp Thr Lys Pro Asp Leu Leu Leu His 
1               5                   10                  15      


Leu Met Thr Lys Glu Trp Gln Leu Glu Leu Pro Lys Leu Leu Ile Ser 
            20                  25                  30          


Val His Gly Gly Leu Gln Asn Phe Glu Leu Gln Pro Lys Leu Lys Gln 
        35                  40                  45              


Val Phe Gly Lys Gly Leu Ile Lys Ala Ala Met Thr Thr Gly Ala Trp 
    50                  55                  60                  


Ile Phe Thr Gly Gly Val Asn Thr Gly Val Ile Arg His Val Gly Asp 
65                  70                  75                  80  


Ala Leu Lys Asp His Ala Ser Lys Ser Arg Gly Lys Ile Cys Thr Ile 
                85                  90                  95      


Gly Ile Ala Pro Trp Gly Ile Val Glu Asn Gln Glu Asp Leu Ile Gly 
            100                 105                 110         


Arg Asp Val Val Arg Pro Tyr Gln Thr Met Ser Asn Pro Met Ser Lys 
        115                 120                 125             


Leu Thr Val Leu Asn Ser Met His Ser His Phe Ile Leu Ala Asp Asn 
    130                 135                 140                 


Gly Thr Thr Gly Lys Tyr Gly Ala Glu Val Lys Leu Arg Arg Gln Leu 
145                 150                 155                 160 


Glu Lys His Ile Ser Leu Gln Lys Ile Asn Thr Arg Ile Gly Gln Gly 
                165                 170                 175     


Val Pro Val Val Ala Leu Ile Val Glu Gly Gly Pro Asn Val Ile Ser 
            180                 185                 190         


Ile Val Leu Glu Tyr Leu Arg Asp Thr Pro Pro Val Pro Val Val Val 
        195                 200                 205             


Cys Asp Gly Ser Gly Arg Ala Ser Asp Ile Leu Ala Phe Gly His Lys 
    210                 215                 220                 


Tyr Ser Glu Glu Gly Gly Leu Ile Asn Glu Ser Leu Arg Asp Gln Leu 
225                 230                 235                 240 


Leu Val Thr Ile Gln Lys Thr Phe Thr Tyr Thr Arg Thr Gln Ala Gln 
                245                 250                 255     


His Leu Phe Ile Ile Leu Met Glu Cys Met Lys Lys Lys Glu Leu Ile 
            260                 265                 270         


Thr Val Phe Arg Met Gly Ser Glu Gly His Gln Asp Ile Asp Leu Ala 
        275                 280                 285             


Ile Leu Thr Ala Leu Leu Lys Gly Ala Asn Ala Ser Ala Pro Asp Gln 
    290                 295                 300                 


Leu Ser Leu Ala Leu Ala Trp Asn Arg Val Asp Ile Ala Arg Ser Gln 
305                 310                 315                 320 


Ile Phe Ile Tyr Gly Gln Gln Trp Pro Val Gly Ser Leu Glu Gln Ala 
                325                 330                 335     


Met Leu Asp Ala Leu Val Leu Asp Arg Val Asp Phe Val Lys Leu Leu 
            340                 345                 350         


Ile Glu Asn Gly Val Ser Met His Arg Phe Leu Thr Ile Ser Arg Leu 
        355                 360                 365             


Glu Glu Leu Tyr Asn Thr Arg His Gly Pro Ser Asn Thr Leu Tyr His 
    370                 375                 380                 


Leu Val Arg Asp Val Lys Lys Gly Asn Leu Pro Pro Asp Tyr Arg Ile 
385                 390                 395                 400 


Ser Leu Ile Asp Ile Gly Leu Val Ile Glu Tyr Leu Met Gly Gly Ala 
                405                 410                 415     


Tyr Arg Cys Asn Tyr Thr Arg Lys Arg Phe Arg Thr Leu Tyr His Asn 
            420                 425                 430         


Leu Phe Gly Pro Lys Arg Asp Asp Ile Pro Leu Arg Arg Gly Arg Lys 
        435                 440                 445             


Thr Thr Lys Lys Arg Glu Glu Glu Val Asp Ile Asp Leu Asp Asp Pro 
    450                 455                 460                 


Glu Ile Asn His Phe Pro Phe Pro Phe His Glu Leu Met Val Trp Ala 
465                 470                 475                 480 


Val Leu Met Lys Arg Gln Lys Met Ala Leu Phe Phe Trp Gln His Gly 
                485                 490                 495     


Glu Glu Ala Met Ala Lys Ala Leu Val Ala Cys Lys Leu Cys Lys Ala 
            500                 505                 510         


Met Ala His Glu Ala Ser Glu Asn Asp Met Val Asp Asp Ile Ser Gln 
        515                 520                 525             


Glu Leu Asn His Asn Ser Arg Asp Phe Gly Gln Leu Ala Val Glu Leu 
    530                 535                 540                 


Leu Asp Gln Ser Tyr Lys Gln Asp Glu Gln Leu Ala Met Lys Leu Leu 
545                 550                 555                 560 


Thr Tyr Glu Leu Lys Asn Trp Ser Asn Ala Thr Cys Leu Gln Leu Ala 
                565                 570                 575     


Val Ala Ala Lys His Arg Asp Phe Ile Ala His Thr Cys Ser Gln Met 
            580                 585                 590         


Leu Leu Thr Asp Met Trp Met Gly Arg Leu Arg Met Arg Lys Asn Ser 
        595                 600                 605             


Gly Leu Lys Val Ile Leu Gly Ile Leu Leu Pro Pro Ser Ile Leu Ser 
    610                 615                 620                 


Leu Glu Phe Lys Asn Lys Asp Asp Met Pro Tyr Met Ser Gln Ala Gln 
625                 630                 635                 640 


Glu Ile His Leu Gln Glu Lys Glu Ala Glu Glu Pro Glu Lys Pro Thr 
                645                 650                 655     


Lys Glu Lys Glu Glu Glu Asp Met Glu Leu Thr Ala Met Leu Gly Arg 
            660                 665                 670         


Asn Asn Gly Glu Ser Ser Arg Lys Lys Asp Glu Glu Glu Val Gln Ser 
        675                 680                 685             


Lys His Arg Leu Ile Pro Leu Gly Arg Lys Ile Tyr Glu Phe Tyr Asn 
    690                 695                 700                 


Ala Pro Ile Val Lys Phe Trp Phe Tyr Thr Leu Ala Tyr Ile Gly Tyr 
705                 710                 715                 720 


Leu Met Leu Phe Asn Tyr Ile Val Leu Val Lys Met Glu Arg Trp Pro 
                725                 730                 735     


Ser Thr Gln Glu Trp Ile Val Ile Ser Tyr Ile Phe Thr Leu Gly Ile 
            740                 745                 750         


Glu Lys Met Arg Glu Ile Leu Met Ser Glu Pro Gly Lys Leu Leu Gln 
        755                 760                 765             


Lys Val Lys Val Trp Leu Gln Glu Tyr Trp Asn Val Thr Asp Leu Ile 
    770                 775                 780                 


Ala Ile Leu Leu Phe Ser Val Gly Met Ile Leu Arg Leu Gln Asp Gln 
785                 790                 795                 800 


Pro Phe Arg Ser Asp Gly Arg Val Ile Tyr Cys Val Asn Ile Ile Tyr 
                805                 810                 815     


Trp Tyr Ile Arg Leu Leu Asp Ile Phe Gly Val Asn Lys Tyr Leu Gly 
            820                 825                 830         


Pro Tyr Val Met Met Ile Gly Lys Met Met Ile Asp Met Met Tyr Phe 
        835                 840                 845             


Val Ile Ile Met Leu Val Val Leu Met Ser Phe Gly Val Ala Arg Gln 
    850                 855                 860                 


Ala Ile Leu Phe Pro Asn Glu Glu Pro Ser Trp Lys Leu Ala Lys Asn 
865                 870                 875                 880 


Ile Phe Tyr Met Pro Tyr Trp Met Ile Tyr Gly Glu Val Phe Ala Asp 
                885                 890                 895     


Gln Ile Asp Pro Pro Cys Gly Gln Asn Glu Thr Arg Glu Asp Gly Lys 
            900                 905                 910         


Ile Ile Gln Leu Pro Pro Cys Lys Thr Gly Ala Trp Ile Val Pro Ala 
        915                 920                 925             


Ile Met Ala Cys Tyr Leu Leu Val Ala Asn Ile Leu Leu Val Asn Leu 
    930                 935                 940                 


Leu Ile Ala Val Phe Asn Asn Thr Phe Phe Glu Val Lys Ser Ile Ser 
945                 950                 955                 960 


Asn Gln Val Trp Lys Phe Gln Arg Tyr Gln Leu Ile Met Thr Phe His 
                965                 970                 975     


Glu Arg Pro Val Leu Pro Pro Pro Leu Ile Ile Phe Ser His Met Thr 
            980                 985                 990         


Met Ile Phe Gln His Leu Cys Cys  Arg Trp Arg Lys His  Glu Ser Asp 
        995                 1000                 1005             


Pro Asp  Glu Arg Asp Tyr Gly  Leu Lys Leu Phe Ile  Thr Asp Asp 
    1010                 1015                 1020             


Glu Leu  Lys Lys Val His Asp  Phe Glu Glu Gln Cys  Ile Glu Glu 
    1025                 1030                 1035             


Tyr Phe  Arg Glu Lys Asp Asp  Arg Phe Asn Ser Ser  Asn Asp Glu 
    1040                 1045                 1050             


Arg Ile  Arg Val Thr Ser Glu  Arg Val Glu Asn Met  Ser Met Arg 
    1055                 1060                 1065             


Leu Glu  Glu Val Asn Glu Arg  Glu His Ser Met Lys  Ala Ser Leu 
    1070                 1075                 1080             


Gln Thr  Val Asp Ile Arg Leu  Ala Gln Leu Glu Asp  Leu Ile Gly 
    1085                 1090                 1095             


Arg Met  Ala Thr Ala Leu Glu  Arg Leu Thr Gly Leu  Glu Arg Ala 
    1100                 1105                 1110             


Glu Ser  Asn Lys Ile Arg Ser  Arg Thr Ser Ser Asp  Cys Thr Asp 
    1115                 1120                 1125             


Ala Ala  Tyr Ile Val Arg Gln  Ser Ser Phe Asn Ser  Gln Glu Gly 
    1130                 1135                 1140             


Asn Thr  Phe Lys Leu Gln Glu  Ser Ile Asp Pro Ala  Gly Glu Glu 
    1145                 1150                 1155             


Thr Met  Ser Pro Thr Ser Pro  Thr Leu Met Pro Arg  Met Arg Ser 
    1160                 1165                 1170             


His Ser  Phe Tyr Ser Val Asn  Met Lys Asp Lys Gly  Gly Ile Glu 
    1175                 1180                 1185             


Lys Leu  Glu Ser Ile Phe Lys  Glu Arg Ser Leu Ser  Leu His Arg 
    1190                 1195                 1200             


Ala Thr  Ser Ser His Ser Val  Ala Lys Glu Pro Lys  Ala Pro Ala 
    1205                 1210                 1215             


Ala Pro  Ala Asn Thr Leu Ala  Ile Val Pro Asp Ser  Arg Arg Pro 
    1220                 1225                 1230             


Ser Ser  Cys Ile Asp Ile Tyr  Val Ser Ala Met Asp  Glu Leu His 
    1235                 1240                 1245             


Cys Asp  Ile Asp Pro Leu Asp  Asn Ser Val Asn Ile  Leu Gly Leu 
    1250                 1255                 1260             


Gly Glu  Pro Ser Phe Ser Thr  Pro Val Pro Ser Thr  Ala Pro Ser 
    1265                 1270                 1275             


Ser Ser  Ala Tyr Ala Thr Leu  Ala Pro Thr Asp Arg  Pro Pro Ser 
    1280                 1285                 1290             


Arg Ser  Ile Asp Phe Glu Asp  Ile Thr Ser Met Asp  Thr Arg Ser 
    1295                 1300                 1305             


Phe Ser  Ser Asp Tyr Thr His  Leu Pro Glu Cys Gln  Asn Pro Trp 
    1310                 1315                 1320             


Asp Ser  Glu Pro Pro Met Tyr  His Thr Ile Glu Arg  Ser Lys Ser 
    1325                 1330                 1335             


Ser Arg  Tyr Leu Ala Thr Thr  Pro Phe Leu Leu Glu  Glu Ala Pro 
    1340                 1345                 1350             


Ile Val  Lys Ser His Ser Phe  Met Phe Ser Pro Ser  Arg Ser Tyr 
    1355                 1360                 1365             


Tyr Ala  Asn Phe Gly Val Pro  Val Lys Thr Ala Glu  Tyr Thr Ser 
    1370                 1375                 1380             


Ile Thr  Asp Cys Ile Asp Thr  Arg Cys Val Asn Ala  Pro Gln Ala 
    1385                 1390                 1395             


Ile Ala  Asp Arg Ala Ala Phe  Pro Gly Gly Leu Gly  Asp Lys Val 
    1400                 1405                 1410             


Glu Asp  Leu Thr Cys Cys His  Pro Glu Arg Glu Ala  Glu Leu Ser 
    1415                 1420                 1425             


His Pro  Ser Ser Asp Ser Glu  Glu Asn Glu Ala Lys  Gly Arg Arg 
    1430                 1435                 1440             


Ala Thr  Ile Ala Ile Ser Ser  Gln Glu Gly Asp Asn  Ser Glu Arg 
    1445                 1450                 1455             


Thr Leu  Ser Asn Asn Ile Thr  Val Pro Lys Ile Glu  Arg Ala Asn 
    1460                 1465                 1470             


Ser Tyr  Ser Ala Glu Glu Pro  Ser Ala Pro Tyr Ala  His Thr Arg 
    1475                 1480                 1485             


Lys Ser  Phe Ser Ile Ser Asp  Lys Leu Asp Arg Gln  Arg Asn Thr 
    1490                 1495                 1500             


Ala Ser  Leu Arg Asn Pro Phe  Gln Arg Ser Lys Ser  Ser Lys Pro 
    1505                 1510                 1515             


Glu Gly  Arg Gly Asp Ser Leu  Ser Met Arg Arg Leu  Ser Arg Thr 
    1520                 1525                 1530             


Ser Ala  Phe Gln Ser Phe Glu  Ser Lys His Asn 
    1535                 1540                 

<210>  376
<211>  5946
<212>  DNA
<213>  Homo sapiens

<400>  376
agctgcagca aaatgaaagc aacaggagct gctccgggga ctgcttttgc cagtacccag     60

aatcagtgct caggctcaga aatcctggat agaaagagca ttttataaaa gagaatgtgt    120

ccacatcata cccagcacca aagaccccca taggtgttgc tgtgggcgtc tgataggcca    180

gcatgttggc ctcaccccca gtatctccgt gcttcagaat gagaaaaatg aaagtcgcct    240

ctcccgaaat gacatccagt ctgaaaagtg gtccatcagc aaacacactc aactcagccc    300

tacggatgct tttgggacca ttgagttcca aggaggtggc cattccaaca aagccatgta    360

tgtgcgagta tcttttgata caaaacctga tctcctctta cacctgatga ccaaggaatg    420

gcagttggag cttcccaagc ttctcatctc tgtccatggg ggcctgcaga actttgaact    480

ccagccaaaa ctcaagcaag tctttgggaa agggctcatc aaagcagcaa tgacaactgg    540

agcgtggata ttcactggag gggttaacac aggtgttatt cgtcatgttg gcgatgcctt    600

gaaggatcat gcctctaagt ctcgaggaaa gatatgcacc ataggtattg ccccctgggg    660

aattgtggaa aaccaggagg acctcattgg aagagatgtt gtccggccat accagaccat    720

gtccaatccc atgagcaagc tcactgttct caacagcatg cattcccact tcattctggc    780

tgacaacggg accactggaa aatatggagc agaggtgaaa cttcgaagac aactggaaaa    840

gcatatttca ctccagaaga taaacacaag aatcggtcaa ggtgttcctg tggtggcact    900

catagtggaa ggaggaccca atgtgatctc gattgttttg gagtaccttc gagacacccc    960

tcccgtgcca gtggttgtct gtgatgggag tggacgggca tcggacatcc tggcctttgg   1020

gcataaatac tcagaagaag gcggactgat aaatgaatct ttgagggacc agctgttggt   1080

gactatacag aagactttca catacactcg aacccaagct cagcatctgt tcatcatcct   1140

catggagtgc atgaagaaga aggaattgat tacggtattt cggatgggat cagaaggaca   1200

ccaggacatt gatttggcta tcctgacagc tttactcaaa ggagccaatg cctcggcccc   1260

agaccaactg agcttagctt tagcctggaa cagagtcgac atcgctcgca gccagatctt   1320

tatttacggg caacagtggc cggtgggatc tctggagcaa gccatgttgg atgccttagt   1380

tctggacaga gtggattttg tgaaattact catagagaat ggagtaagca tgcaccgttt   1440

tctcaccatc tccagactag aggaattgta caatacgaga catgggccct caaatacatt   1500

gtaccacttg gtcagggatg tcaaaaagcg agagtatcca ggtttcggtt ggatctattt   1560

taaggggaac ctgcccccag actacagaat cagcctgatt gacatcggcc tggtgatcga   1620

gtacctgatg ggcggggctt atcgctgcaa ctacacgcgc aagcgcttcc ggaccctcta   1680

ccacaacctc ttcggcccca agagggatga tattcccttg aggcgaggaa gaaagacaac   1740

caagaaacgt gaagaagagg tggacattga cttggatgat cctgagatca accacttccc   1800

cttccctttc catgagctca tggtgtgggc tgttctcatg aagcggcaga agatggccct   1860

gttcttctgg cagcacggtg aggaggccat ggccaaggcc ctggtggcct gcaagctctg   1920

caaagccatg gctcatgagg cctctgagaa cgacatggtt gacgacattt cccaggagct   1980

gaatcacaat tccagagact ttggccagct ggctgtggag ctcctggacc agtcctacaa   2040

gcaggacgaa cagctggcca tgaaactgct gacgtatgag ctgaagaact ggagcaacgc   2100

cacgtgcctg cagcttgccg tggctgccaa acaccgcgac ttcatcgcgc acacgtgcag   2160

ccagatgctg ctcaccgaca tgtggatggg ccggctccgc atgcgcaaga actcaggcct   2220

caaggtaatt ctgggaattc tacttcctcc ttcaattctc agcttggagt tcaagaacaa   2280

agacgacatg ccctatatgt ctcaggccca ggaaatccac ctccaagaga aggaggcaga   2340

agaaccagag aagcccacaa aggaaaaaga ggaagaggac atggagctca cagcaatgtt   2400

gggacgaaac aacggggagt cctccaggaa gaaggatgaa gaggaagttc agagcaagca   2460

ccggttaatc cccctcggca gaaaaatcta tgaattctac aatgcaccca tcgtgaagtt   2520

ctggttctac acactggcgt atatcggata cctgatgctc ttcaactata tcgtgttagt   2580

gaagatggaa cgctggccgt ccacccagga atggatcgta atctcctata ttttcaccct   2640

gggaatagaa aagatgagag agattctgat gtcagagcca gggaagttgc tacagaaagt   2700

gaaggtatgg ctgcaggagt actggaatgt cacggacctc atcgccatcc ttctgttttc   2760

tgtcggaatg atccttcgtc tccaagacca gcccttcagg agtgacggga gggtcatcta   2820

ctgcgtgaac atcatttact ggtatatccg tctcctagac atcttcggcg tgaacaagta   2880

tttgggcccg tatgtaatga tgattggaaa aatgatgata gacatgatgt actttgtcat   2940

cattatgctg gtggttctga tgagctttgg ggtcgccagg caagccatcc tttttcccaa   3000

tgaggagcca tcatggaaac tggccaagaa catcttctac atgccctatt ggatgattta   3060

tggggaagtg tttgcggacc agatagaccc tccctgtgga cagaatgaga cccgagagga   3120

tggtaaaata atccagctgc ctccctgcaa gacaggagct tggatcgtgc cggccatcat   3180

ggcctgctac ctcttagtgg caaacatctt gctggtcaac ctcctcattg ctgtctttaa   3240

caatacattt tttgaagtaa aatcgatatc caaccaagtc tggaagtttc agaggtatca   3300

gctcatcatg actttccatg aaaggccagt tctgccccca ccactgatca tcttcagcca   3360

catgaccatg atattccagc acctgtgctg ccgatggagg aaacacgaga gcgacccgga   3420

tgaaagggac tacggcctga aactcttcat aaccgatgat gagctcaaga aagtacatga   3480

ctttgaagag caatgcatag aagaatactt cagagaaaag gatgatcggt tcaactcatc   3540

taatgatgag aggatacggg tgacttcaga aagggtggag aacatgtcta tgcggctgga   3600

ggaagtcaac gagagagagc actccatgaa ggcttcactc cagaccgtgg acatccggct   3660

ggcgcagctg gaagacctta tcgggcgcat ggccacggcc ctggagcgcc tgacaggtct   3720

ggagcgggcc gagtccaaca aaatccgctc gaggacctcg tcagactgca cggacgccgc   3780

ctacattgtc cgtcagagca gcttcaacag ccaggaaggg aacaccttca agctccaaga   3840

gagtatagac cctgcaggtg aggagaccat gtccccaact tctccaacct taatgccccg   3900

tatgcgaagc cattctttct attcggtcaa tatgaaagac aaaggtggta tagaaaagtt   3960

ggaaagtatt tttaaagaaa ggtccctgag cctacaccgg gctactagtt cccactctgt   4020

agcaaaagaa cccaaagctc ctgcagcccc tgccaacacc ttggccattg ttcctgattc   4080

cagaagacca tcatcgtgta tagacatcta tgtctctgct atggatgagc tccactgtga   4140

tatagaccct ctggacaatt ccgtgaacat ccttgggctg ggcgagccaa gcttttcaac   4200

tccagtacct tccacagccc cttcaagtag tgcctatgca acacttgcac ccacagacag   4260

acctccaagc cggagcattg attttgagga catcacctcc atggacacta gatctttttc   4320

ttcagactac acccacctcc cagaatgcca aaacccctgg gactcagagc ctccgatgta   4380

ccacaccatt gagcgttcca aaagtagccg ctacctagcc accacaccct ttcttctaga   4440

agaggctccc attgtgaaat ctcatagctt tatgttttcc ccctcaagga gctattatgc   4500

caactttggg gtgcctgtaa aaacagcaga atacacaagt attacagact gtattgacac   4560

aaggtgtgtc aatgcccctc aagcaattgc ggacagagct gccttccctg gaggtcttgg   4620

agacaaagtg gaggacttaa cttgctgcca tccagagcga gaagcagaac tgagtcaccc   4680

cagctctgac agtgaggaga atgaggccaa aggccgcaga gccaccattg caatatcctc   4740

ccaggagggt gataactcag agagaaccct gtccaacaac atcactgttc ccaagataga   4800

gcgcgccaac agctactcgg cagaggagcc aagtgcgcca tatgcacaca ccaggaagag   4860

cttctccatc agtgacaaac tcgacaggca gcggaacaca gcaagcctgc gaaatccctt   4920

ccagagaagc aagtcctcca agccggaggg ccgaggggac agcctgtcca tgaggagact   4980

gtccagaaca tcggctttcc aaagctttga aagcaagcac aactaaacct tcttaatatc   5040

cgccacagaa ggctcaagaa tccagcccta aaattctctc caactccagt ttttcccctt   5100

tccttgaatc atacctgctt tattcttagc tgagcaaaac aagcaatgct ttgggaggtg   5160

ttaactcaaa ggtgacttct gggccacaga tcaagaaagc atttgatctg acccagtgcc   5220

agacacaggg gatttaaggc atgttcacac ttgctgggca gggaggggga agagagggag   5280

aaggaagggt tagagatgaa tgtgtatccg cagtcacagc agaaagccat gagagcaggg   5340

gaaacaaggg gcttcgagca cgctccatgc caggaggcat ctgttgattt ctgaccatta   5400

tcaagagttg taggatgcag ggctaaattg caaaataaaa taaaatagcc agcgtacaca   5460

atgagatatt ctaaacttcc attctgtttt cttttcacat tggctccatc actggtgact   5520

gatgaagagc atcctcttta ttcagtataa gccggcagca agcagttcta cctaacgtcc   5580

cacatccttc tcatgccaac acttctgtaa ttgatcatta taaagaaaaa acaaggtaac   5640

agtcatagtt cacctgtctc ttatctattc acttctggtg ccacaactgt ttatcctttt   5700

ttgaagaaaa taagggaaca gaaatgcctt tttgtattgc aatcgaaatg aaagaagagt   5760

tgatgttaaa aaaacaaaag tcaagtgatt tattatatac agtgggcgtt caagtctagt   5820

cgagcaagct caggagaatg taattaaata attttatatt ttttaattta ttttgtatct   5880

cacctgtcat ggatgaattc attcactgaa tatgtaatat tgaacttaaa aaaaaaaaaa   5940

aaaaaa                                                              5946


<210>  377
<211>  1556
<212>  PRT
<213>  Homo sapiens

<400>  377


Met Tyr Val Arg Val Ser Phe Asp Thr Lys Pro Asp Leu Leu Leu His 
1               5                   10                  15      


Leu Met Thr Lys Glu Trp Gln Leu Glu Leu Pro Lys Leu Leu Ile Ser 
            20                  25                  30          


Val His Gly Gly Leu Gln Asn Phe Glu Leu Gln Pro Lys Leu Lys Gln 
        35                  40                  45              


Val Phe Gly Lys Gly Leu Ile Lys Ala Ala Met Thr Thr Gly Ala Trp 
    50                  55                  60                  


Ile Phe Thr Gly Gly Val Asn Thr Gly Val Ile Arg His Val Gly Asp 
65                  70                  75                  80  


Ala Leu Lys Asp His Ala Ser Lys Ser Arg Gly Lys Ile Cys Thr Ile 
                85                  90                  95      


Gly Ile Ala Pro Trp Gly Ile Val Glu Asn Gln Glu Asp Leu Ile Gly 
            100                 105                 110         


Arg Asp Val Val Arg Pro Tyr Gln Thr Met Ser Asn Pro Met Ser Lys 
        115                 120                 125             


Leu Thr Val Leu Asn Ser Met His Ser His Phe Ile Leu Ala Asp Asn 
    130                 135                 140                 


Gly Thr Thr Gly Lys Tyr Gly Ala Glu Val Lys Leu Arg Arg Gln Leu 
145                 150                 155                 160 


Glu Lys His Ile Ser Leu Gln Lys Ile Asn Thr Arg Ile Gly Gln Gly 
                165                 170                 175     


Val Pro Val Val Ala Leu Ile Val Glu Gly Gly Pro Asn Val Ile Ser 
            180                 185                 190         


Ile Val Leu Glu Tyr Leu Arg Asp Thr Pro Pro Val Pro Val Val Val 
        195                 200                 205             


Cys Asp Gly Ser Gly Arg Ala Ser Asp Ile Leu Ala Phe Gly His Lys 
    210                 215                 220                 


Tyr Ser Glu Glu Gly Gly Leu Ile Asn Glu Ser Leu Arg Asp Gln Leu 
225                 230                 235                 240 


Leu Val Thr Ile Gln Lys Thr Phe Thr Tyr Thr Arg Thr Gln Ala Gln 
                245                 250                 255     


His Leu Phe Ile Ile Leu Met Glu Cys Met Lys Lys Lys Glu Leu Ile 
            260                 265                 270         


Thr Val Phe Arg Met Gly Ser Glu Gly His Gln Asp Ile Asp Leu Ala 
        275                 280                 285             


Ile Leu Thr Ala Leu Leu Lys Gly Ala Asn Ala Ser Ala Pro Asp Gln 
    290                 295                 300                 


Leu Ser Leu Ala Leu Ala Trp Asn Arg Val Asp Ile Ala Arg Ser Gln 
305                 310                 315                 320 


Ile Phe Ile Tyr Gly Gln Gln Trp Pro Val Gly Ser Leu Glu Gln Ala 
                325                 330                 335     


Met Leu Asp Ala Leu Val Leu Asp Arg Val Asp Phe Val Lys Leu Leu 
            340                 345                 350         


Ile Glu Asn Gly Val Ser Met His Arg Phe Leu Thr Ile Ser Arg Leu 
        355                 360                 365             


Glu Glu Leu Tyr Asn Thr Arg His Gly Pro Ser Asn Thr Leu Tyr His 
    370                 375                 380                 


Leu Val Arg Asp Val Lys Lys Arg Glu Tyr Pro Gly Phe Gly Trp Ile 
385                 390                 395                 400 


Tyr Phe Lys Gly Asn Leu Pro Pro Asp Tyr Arg Ile Ser Leu Ile Asp 
                405                 410                 415     


Ile Gly Leu Val Ile Glu Tyr Leu Met Gly Gly Ala Tyr Arg Cys Asn 
            420                 425                 430         


Tyr Thr Arg Lys Arg Phe Arg Thr Leu Tyr His Asn Leu Phe Gly Pro 
        435                 440                 445             


Lys Arg Asp Asp Ile Pro Leu Arg Arg Gly Arg Lys Thr Thr Lys Lys 
    450                 455                 460                 


Arg Glu Glu Glu Val Asp Ile Asp Leu Asp Asp Pro Glu Ile Asn His 
465                 470                 475                 480 


Phe Pro Phe Pro Phe His Glu Leu Met Val Trp Ala Val Leu Met Lys 
                485                 490                 495     


Arg Gln Lys Met Ala Leu Phe Phe Trp Gln His Gly Glu Glu Ala Met 
            500                 505                 510         


Ala Lys Ala Leu Val Ala Cys Lys Leu Cys Lys Ala Met Ala His Glu 
        515                 520                 525             


Ala Ser Glu Asn Asp Met Val Asp Asp Ile Ser Gln Glu Leu Asn His 
    530                 535                 540                 


Asn Ser Arg Asp Phe Gly Gln Leu Ala Val Glu Leu Leu Asp Gln Ser 
545                 550                 555                 560 


Tyr Lys Gln Asp Glu Gln Leu Ala Met Lys Leu Leu Thr Tyr Glu Leu 
                565                 570                 575     


Lys Asn Trp Ser Asn Ala Thr Cys Leu Gln Leu Ala Val Ala Ala Lys 
            580                 585                 590         


His Arg Asp Phe Ile Ala His Thr Cys Ser Gln Met Leu Leu Thr Asp 
        595                 600                 605             


Met Trp Met Gly Arg Leu Arg Met Arg Lys Asn Ser Gly Leu Lys Val 
    610                 615                 620                 


Ile Leu Gly Ile Leu Leu Pro Pro Ser Ile Leu Ser Leu Glu Phe Lys 
625                 630                 635                 640 


Asn Lys Asp Asp Met Pro Tyr Met Ser Gln Ala Gln Glu Ile His Leu 
                645                 650                 655     


Gln Glu Lys Glu Ala Glu Glu Pro Glu Lys Pro Thr Lys Glu Lys Glu 
            660                 665                 670         


Glu Glu Asp Met Glu Leu Thr Ala Met Leu Gly Arg Asn Asn Gly Glu 
        675                 680                 685             


Ser Ser Arg Lys Lys Asp Glu Glu Glu Val Gln Ser Lys His Arg Leu 
    690                 695                 700                 


Ile Pro Leu Gly Arg Lys Ile Tyr Glu Phe Tyr Asn Ala Pro Ile Val 
705                 710                 715                 720 


Lys Phe Trp Phe Tyr Thr Leu Ala Tyr Ile Gly Tyr Leu Met Leu Phe 
                725                 730                 735     


Asn Tyr Ile Val Leu Val Lys Met Glu Arg Trp Pro Ser Thr Gln Glu 
            740                 745                 750         


Trp Ile Val Ile Ser Tyr Ile Phe Thr Leu Gly Ile Glu Lys Met Arg 
        755                 760                 765             


Glu Ile Leu Met Ser Glu Pro Gly Lys Leu Leu Gln Lys Val Lys Val 
    770                 775                 780                 


Trp Leu Gln Glu Tyr Trp Asn Val Thr Asp Leu Ile Ala Ile Leu Leu 
785                 790                 795                 800 


Phe Ser Val Gly Met Ile Leu Arg Leu Gln Asp Gln Pro Phe Arg Ser 
                805                 810                 815     


Asp Gly Arg Val Ile Tyr Cys Val Asn Ile Ile Tyr Trp Tyr Ile Arg 
            820                 825                 830         


Leu Leu Asp Ile Phe Gly Val Asn Lys Tyr Leu Gly Pro Tyr Val Met 
        835                 840                 845             


Met Ile Gly Lys Met Met Ile Asp Met Met Tyr Phe Val Ile Ile Met 
    850                 855                 860                 


Leu Val Val Leu Met Ser Phe Gly Val Ala Arg Gln Ala Ile Leu Phe 
865                 870                 875                 880 


Pro Asn Glu Glu Pro Ser Trp Lys Leu Ala Lys Asn Ile Phe Tyr Met 
                885                 890                 895     


Pro Tyr Trp Met Ile Tyr Gly Glu Val Phe Ala Asp Gln Ile Asp Pro 
            900                 905                 910         


Pro Cys Gly Gln Asn Glu Thr Arg Glu Asp Gly Lys Ile Ile Gln Leu 
        915                 920                 925             


Pro Pro Cys Lys Thr Gly Ala Trp Ile Val Pro Ala Ile Met Ala Cys 
    930                 935                 940                 


Tyr Leu Leu Val Ala Asn Ile Leu Leu Val Asn Leu Leu Ile Ala Val 
945                 950                 955                 960 


Phe Asn Asn Thr Phe Phe Glu Val Lys Ser Ile Ser Asn Gln Val Trp 
                965                 970                 975     


Lys Phe Gln Arg Tyr Gln Leu Ile Met Thr Phe His Glu Arg Pro Val 
            980                 985                 990         


Leu Pro Pro Pro Leu Ile Ile Phe  Ser His Met Thr Met  Ile Phe Gln 
        995                 1000                 1005             


His Leu  Cys Cys Arg Trp Arg  Lys His Glu Ser Asp  Pro Asp Glu 
    1010                 1015                 1020             


Arg Asp  Tyr Gly Leu Lys Leu  Phe Ile Thr Asp Asp  Glu Leu Lys 
    1025                 1030                 1035             


Lys Val  His Asp Phe Glu Glu  Gln Cys Ile Glu Glu  Tyr Phe Arg 
    1040                 1045                 1050             


Glu Lys  Asp Asp Arg Phe Asn  Ser Ser Asn Asp Glu  Arg Ile Arg 
    1055                 1060                 1065             


Val Thr  Ser Glu Arg Val Glu  Asn Met Ser Met Arg  Leu Glu Glu 
    1070                 1075                 1080             


Val Asn  Glu Arg Glu His Ser  Met Lys Ala Ser Leu  Gln Thr Val 
    1085                 1090                 1095             


Asp Ile  Arg Leu Ala Gln Leu  Glu Asp Leu Ile Gly  Arg Met Ala 
    1100                 1105                 1110             


Thr Ala  Leu Glu Arg Leu Thr  Gly Leu Glu Arg Ala  Glu Ser Asn 
    1115                 1120                 1125             


Lys Ile  Arg Ser Arg Thr Ser  Ser Asp Cys Thr Asp  Ala Ala Tyr 
    1130                 1135                 1140             


Ile Val  Arg Gln Ser Ser Phe  Asn Ser Gln Glu Gly  Asn Thr Phe 
    1145                 1150                 1155             


Lys Leu  Gln Glu Ser Ile Asp  Pro Ala Gly Glu Glu  Thr Met Ser 
    1160                 1165                 1170             


Pro Thr  Ser Pro Thr Leu Met  Pro Arg Met Arg Ser  His Ser Phe 
    1175                 1180                 1185             


Tyr Ser  Val Asn Met Lys Asp  Lys Gly Gly Ile Glu  Lys Leu Glu 
    1190                 1195                 1200             


Ser Ile  Phe Lys Glu Arg Ser  Leu Ser Leu His Arg  Ala Thr Ser 
    1205                 1210                 1215             


Ser His  Ser Val Ala Lys Glu  Pro Lys Ala Pro Ala  Ala Pro Ala 
    1220                 1225                 1230             


Asn Thr  Leu Ala Ile Val Pro  Asp Ser Arg Arg Pro  Ser Ser Cys 
    1235                 1240                 1245             


Ile Asp  Ile Tyr Val Ser Ala  Met Asp Glu Leu His  Cys Asp Ile 
    1250                 1255                 1260             


Asp Pro  Leu Asp Asn Ser Val  Asn Ile Leu Gly Leu  Gly Glu Pro 
    1265                 1270                 1275             


Ser Phe  Ser Thr Pro Val Pro  Ser Thr Ala Pro Ser  Ser Ser Ala 
    1280                 1285                 1290             


Tyr Ala  Thr Leu Ala Pro Thr  Asp Arg Pro Pro Ser  Arg Ser Ile 
    1295                 1300                 1305             


Asp Phe  Glu Asp Ile Thr Ser  Met Asp Thr Arg Ser  Phe Ser Ser 
    1310                 1315                 1320             


Asp Tyr  Thr His Leu Pro Glu  Cys Gln Asn Pro Trp  Asp Ser Glu 
    1325                 1330                 1335             


Pro Pro  Met Tyr His Thr Ile  Glu Arg Ser Lys Ser  Ser Arg Tyr 
    1340                 1345                 1350             


Leu Ala  Thr Thr Pro Phe Leu  Leu Glu Glu Ala Pro  Ile Val Lys 
    1355                 1360                 1365             


Ser His  Ser Phe Met Phe Ser  Pro Ser Arg Ser Tyr  Tyr Ala Asn 
    1370                 1375                 1380             


Phe Gly  Val Pro Val Lys Thr  Ala Glu Tyr Thr Ser  Ile Thr Asp 
    1385                 1390                 1395             


Cys Ile  Asp Thr Arg Cys Val  Asn Ala Pro Gln Ala  Ile Ala Asp 
    1400                 1405                 1410             


Arg Ala  Ala Phe Pro Gly Gly  Leu Gly Asp Lys Val  Glu Asp Leu 
    1415                 1420                 1425             


Thr Cys  Cys His Pro Glu Arg  Glu Ala Glu Leu Ser  His Pro Ser 
    1430                 1435                 1440             


Ser Asp  Ser Glu Glu Asn Glu  Ala Lys Gly Arg Arg  Ala Thr Ile 
    1445                 1450                 1455             


Ala Ile  Ser Ser Gln Glu Gly  Asp Asn Ser Glu Arg  Thr Leu Ser 
    1460                 1465                 1470             


Asn Asn  Ile Thr Val Pro Lys  Ile Glu Arg Ala Asn  Ser Tyr Ser 
    1475                 1480                 1485             


Ala Glu  Glu Pro Ser Ala Pro  Tyr Ala His Thr Arg  Lys Ser Phe 
    1490                 1495                 1500             


Ser Ile  Ser Asp Lys Leu Asp  Arg Gln Arg Asn Thr  Ala Ser Leu 
    1505                 1510                 1515             


Arg Asn  Pro Phe Gln Arg Ser  Lys Ser Ser Lys Pro  Glu Gly Arg 
    1520                 1525                 1530             


Gly Asp  Ser Leu Ser Met Arg  Arg Leu Ser Arg Thr  Ser Ala Phe 
    1535                 1540                 1545             


Gln Ser  Phe Glu Ser Lys His  Asn 
    1550                 1555     

<210>  378
<211>  6015
<212>  DNA
<213>  Homo sapiens

<400>  378
agctgcagca aaatgaaagc aacaggagct gctccgggga ctgcttttgc cagtacccag     60

aatcagtgct caggctcaga aatcctggat agaaagagca ttttataaaa gagaatgtgt    120

ccacatcata cccagcacca aagaccccca taggtgttgc tgtgggcgtc tgataggcca    180

gcatgttggc ctcaccccca gtatctccgt gcttcagaat gagaaaaatg aaagtcgcct    240

ctcccgaaat gacatccagt ctgaaaagtg gtccatcagc aaacacactc aactcagccc    300

tacggatgct tttgggacca ttgagttcca aggaggtggc cattccaaca aagccatgta    360

tgtgcgagta tcttttgata caaaacctga tctcctctta cacctgatga ccaaggaatg    420

gcagttggag cttcccaagc ttctcatctc tgtccatggg ggcctgcaga actttgaact    480

ccagccaaaa ctcaagcaag tctttgggaa agggctcatc aaagcagcaa tgacaactgg    540

agcgtggata ttcactggag gggttaacac aggtgttatt cgtcatgttg gcgatgcctt    600

gaaggatcat gcctctaagt ctcgaggaaa gatatgcacc ataggtattg ccccctgggg    660

aattgtggaa aaccaggagg acctcattgg aagagatgtt gtccggccat accagaccat    720

gtccaatccc atgagcaagc tcactgttct caacagcatg cattcccact tcattctggc    780

tgacaacggg accactggaa aatatggagc agaggtgaaa cttcgaagac aactggaaaa    840

gcatatttca ctccagaaga taaacacaag atgcctgccg tttttctctc ttgactcccg    900

cttgttttat tcattttggg gtagttgcca gttagactca gttggaatcg gtcaaggtgt    960

tcctgtggtg gcactcatag tggaaggagg acccaatgtg atctcgattg ttttggagta   1020

ccttcgagac acccctcccg tgccagtggt tgtctgtgat gggagtggac gggcatcgga   1080

catcctggcc tttgggcata aatactcaga agaaggcgga ctgataaatg aatctttgag   1140

ggaccagctg ttggtgacta tacagaagac tttcacatac actcgaaccc aagctcagca   1200

tctgttcatc atcctcatgg agtgcatgaa gaagaaggaa ttgattacgg tatttcggat   1260

gggatcagaa ggacaccagg acattgattt ggctatcctg acagctttac tcaaaggagc   1320

caatgcctcg gccccagacc aactgagctt agctttagcc tggaacagag tcgacatcgc   1380

tcgcagccag atctttattt acgggcaaca gtggccggtg ggatctctgg agcaagccat   1440

gttggatgcc ttagttctgg acagagtgga ttttgtgaaa ttactcatag agaatggagt   1500

aagcatgcac cgttttctca ccatctccag actagaggaa ttgtacaata cgagacatgg   1560

gccctcaaat acattgtacc acttggtcag ggatgtcaaa aaggggaacc tgcccccaga   1620

ctacagaatc agcctgattg acatcggcct ggtgatcgag tacctgatgg gcggggctta   1680

tcgctgcaac tacacgcgca agcgcttccg gaccctctac cacaacctct tcggccccaa   1740

gaggcccaaa gccttgaaac tgctgggaat ggaggatgat attcccttga ggcgaggaag   1800

aaagacaacc aagaaacgtg aagaagaggt ggacattgac ttggatgatc ctgagatcaa   1860

ccacttcccc ttccctttcc atgagctcat ggtgtgggct gttctcatga agcggcagaa   1920

gatggccctg ttcttctggc agcacggtga ggaggccatg gccaaggccc tggtggcctg   1980

caagctctgc aaagccatgg ctcatgaggc ctctgagaac gacatggttg acgacatttc   2040

ccaggagctg aatcacaatt ccagagactt tggccagctg gctgtggagc tcctggacca   2100

gtcctacaag caggacgaac agctggccat gaaactgctg acgtatgagc tgaagaactg   2160

gagcaacgcc acgtgcctgc agcttgccgt ggctgccaaa caccgcgact tcatcgcgca   2220

cacgtgcagc cagatgctgc tcaccgacat gtggatgggc cggctccgca tgcgcaagaa   2280

ctcaggcctc aaggtaattc tgggaattct acttcctcct tcaattctca gcttggagtt   2340

caagaacaaa gacgacatgc cctatatgtc tcaggcccag gaaatccacc tccaagagaa   2400

ggaggcagaa gaaccagaga agcccacaaa ggaaaaagag gaagaggaca tggagctcac   2460

agcaatgttg ggacgaaaca acggggagtc ctccaggaag aaggatgaag aggaagttca   2520

gagcaagcac cggttaatcc ccctcggcag aaaaatctat gaattctaca atgcacccat   2580

cgtgaagttc tggttctaca cactggcgta tatcggatac ctgatgctct tcaactatat   2640

cgtgttagtg aagatggaac gctggccgtc cacccaggaa tggatcgtaa tctcctatat   2700

tttcaccctg ggaatagaaa agatgagaga gattctgatg tcagagccag ggaagttgct   2760

acagaaagtg aaggtatggc tgcaggagta ctggaatgtc acggacctca tcgccatcct   2820

tctgttttct gtcggaatga tccttcgtct ccaagaccag cccttcagga gtgacgggag   2880

ggtcatctac tgcgtgaaca tcatttactg gtatatccgt ctcctagaca tcttcggcgt   2940

gaacaagtat ttgggcccgt atgtaatgat gattggaaaa atgatgatag acatgatgta   3000

ctttgtcatc attatgctgg tggttctgat gagctttggg gtcgccaggc aagccatcct   3060

ttttcccaat gaggagccat catggaaact ggccaagaac atcttctaca tgccctattg   3120

gatgatttat ggggaagtgt ttgcggacca gatagaccct ccctgtggac agaatgagac   3180

ccgagaggat ggtaaaataa tccagctgcc tccctgcaag acaggagctt ggatcgtgcc   3240

ggccatcatg gcctgctacc tcttagtggc aaacatcttg ctggtcaacc tcctcattgc   3300

tgtctttaac aatacatttt ttgaagtaaa atcgatatcc aaccaagtct ggaagtttca   3360

gaggtatcag ctcatcatga ctttccatga aaggccagtt ctgcccccac cactgatcat   3420

cttcagccac atgaccatga tattccagca cctgtgctgc cgatggagga aacacgagag   3480

cgacccggat gaaagggact acggcctgaa actcttcata accgatgatg agctcaagaa   3540

agtacatgac tttgaagagc aatgcataga agaatacttc agagaaaagg atgatcggtt   3600

caactcatct aatgatgaga ggatacgggt gacttcagaa agggtggaga acatgtctat   3660

gcggctggag gaagtcaacg agagagagca ctccatgaag gcttcactcc agaccgtgga   3720

catccggctg gcgcagctgg aagaccttat cgggcgcatg gccacggccc tggagcgcct   3780

gacaggtctg gagcgggccg agtccaacaa aatccgctcg aggacctcgt cagactgcac   3840

ggacgccgcc tacattgtcc gtcagagcag cttcaacagc caggaaggga acaccttcaa   3900

gctccaagag agtatagacc ctgcaggtga ggagaccatg tccccaactt ctccaacctt   3960

aatgccccgt atgcgaagcc attctttcta ttcggtcaat atgaaagaca aaggtggtat   4020

agaaaagttg gaaagtattt ttaaagaaag gtccctgagc ctacaccggg ctactagttc   4080

ccactctgta gcaaaagaac ccaaagctcc tgcagcccct gccaacacct tggccattgt   4140

tcctgattcc agaagaccat catcgtgtat agacatctat gtctctgcta tggatgagct   4200

ccactgtgat atagaccctc tggacaattc cgtgaacatc cttgggctgg gcgagccaag   4260

cttttcaact ccagtacctt ccacagcccc ttcaagtagt gcctatgcaa cacttgcacc   4320

cacagacaga cctccaagcc ggagcattga ttttgaggac atcacctcca tggacactag   4380

atctttttct tcagactaca cccacctccc agaatgccaa aacccctggg actcagagcc   4440

tccgatgtac cacaccattg agcgttccaa aagtagccgc tacctagcca ccacaccctt   4500

tcttctagaa gaggctccca ttgtgaaatc tcatagcttt atgttttccc cctcaaggag   4560

ctattatgcc aactttgggg tgcctgtaaa aacagcagaa tacacaagta ttacagactg   4620

tattgacaca aggtgtgtca atgcccctca agcaattgcg gacagagctg ccttccctgg   4680

aggtcttgga gacaaagtgg aggacttaac ttgctgccat ccagagcgag aagcagaact   4740

gagtcacccc agctctgaca gtgaggagaa tgaggccaaa ggccgcagag ccaccattgc   4800

aatatcctcc caggagggtg ataactcaga gagaaccctg tccaacaaca tcactgttcc   4860

caagatagag cgcgccaaca gctactcggc agaggagcca agtgcgccat atgcacacac   4920

caggaagagc ttctccatca gtgacaaact cgacaggcag cggaacacag caagcctgcg   4980

aaatcccttc cagagaagca agtcctccaa gccggagggc cgaggggaca gcctgtccat   5040

gaggagactg tccagaacat cggctttcca aagctttgaa agcaagcaca actaaacctt   5100

cttaatatcc gccacagaag gctcaagaat ccagccctaa aattctctcc aactccagtt   5160

tttccccttt ccttgaatca tacctgcttt attcttagct gagcaaaaca agcaatgctt   5220

tgggaggtgt taactcaaag gtgacttctg ggccacagat caagaaagca tttgatctga   5280

cccagtgcca gacacagggg atttaaggca tgttcacact tgctgggcag ggagggggaa   5340

gagagggaga aggaagggtt agagatgaat gtgtatccgc agtcacagca gaaagccatg   5400

agagcagggg aaacaagggg cttcgagcac gctccatgcc aggaggcatc tgttgatttc   5460

tgaccattat caagagttgt aggatgcagg gctaaattgc aaaataaaat aaaatagcca   5520

gcgtacacaa tgagatattc taaacttcca ttctgttttc ttttcacatt ggctccatca   5580

ctggtgactg atgaagagca tcctctttat tcagtataag ccggcagcaa gcagttctac   5640

ctaacgtccc acatccttct catgccaaca cttctgtaat tgatcattat aaagaaaaaa   5700

caaggtaaca gtcatagttc acctgtctct tatctattca cttctggtgc cacaactgtt   5760

tatccttttt tgaagaaaat aagggaacag aaatgccttt ttgtattgca atcgaaatga   5820

aagaagagtt gatgttaaaa aaacaaaagt caagtgattt attatataca gtgggcgttc   5880

aagtctagtc gagcaagctc aggagaatgt aattaaataa ttttatattt tttaatttat   5940

tttgtatctc acctgtcatg gatgaattca ttcactgaat atgtaatatt gaacttaaaa   6000

aaaaaaaaaa aaaaa                                                    6015


<210>  379
<211>  1579
<212>  PRT
<213>  Homo sapiens

<400>  379


Met Tyr Val Arg Val Ser Phe Asp Thr Lys Pro Asp Leu Leu Leu His 
1               5                   10                  15      


Leu Met Thr Lys Glu Trp Gln Leu Glu Leu Pro Lys Leu Leu Ile Ser 
            20                  25                  30          


Val His Gly Gly Leu Gln Asn Phe Glu Leu Gln Pro Lys Leu Lys Gln 
        35                  40                  45              


Val Phe Gly Lys Gly Leu Ile Lys Ala Ala Met Thr Thr Gly Ala Trp 
    50                  55                  60                  


Ile Phe Thr Gly Gly Val Asn Thr Gly Val Ile Arg His Val Gly Asp 
65                  70                  75                  80  


Ala Leu Lys Asp His Ala Ser Lys Ser Arg Gly Lys Ile Cys Thr Ile 
                85                  90                  95      


Gly Ile Ala Pro Trp Gly Ile Val Glu Asn Gln Glu Asp Leu Ile Gly 
            100                 105                 110         


Arg Asp Val Val Arg Pro Tyr Gln Thr Met Ser Asn Pro Met Ser Lys 
        115                 120                 125             


Leu Thr Val Leu Asn Ser Met His Ser His Phe Ile Leu Ala Asp Asn 
    130                 135                 140                 


Gly Thr Thr Gly Lys Tyr Gly Ala Glu Val Lys Leu Arg Arg Gln Leu 
145                 150                 155                 160 


Glu Lys His Ile Ser Leu Gln Lys Ile Asn Thr Arg Cys Leu Pro Phe 
                165                 170                 175     


Phe Ser Leu Asp Ser Arg Leu Phe Tyr Ser Phe Trp Gly Ser Cys Gln 
            180                 185                 190         


Leu Asp Ser Val Gly Ile Gly Gln Gly Val Pro Val Val Ala Leu Ile 
        195                 200                 205             


Val Glu Gly Gly Pro Asn Val Ile Ser Ile Val Leu Glu Tyr Leu Arg 
    210                 215                 220                 


Asp Thr Pro Pro Val Pro Val Val Val Cys Asp Gly Ser Gly Arg Ala 
225                 230                 235                 240 


Ser Asp Ile Leu Ala Phe Gly His Lys Tyr Ser Glu Glu Gly Gly Leu 
                245                 250                 255     


Ile Asn Glu Ser Leu Arg Asp Gln Leu Leu Val Thr Ile Gln Lys Thr 
            260                 265                 270         


Phe Thr Tyr Thr Arg Thr Gln Ala Gln His Leu Phe Ile Ile Leu Met 
        275                 280                 285             


Glu Cys Met Lys Lys Lys Glu Leu Ile Thr Val Phe Arg Met Gly Ser 
    290                 295                 300                 


Glu Gly His Gln Asp Ile Asp Leu Ala Ile Leu Thr Ala Leu Leu Lys 
305                 310                 315                 320 


Gly Ala Asn Ala Ser Ala Pro Asp Gln Leu Ser Leu Ala Leu Ala Trp 
                325                 330                 335     


Asn Arg Val Asp Ile Ala Arg Ser Gln Ile Phe Ile Tyr Gly Gln Gln 
            340                 345                 350         


Trp Pro Val Gly Ser Leu Glu Gln Ala Met Leu Asp Ala Leu Val Leu 
        355                 360                 365             


Asp Arg Val Asp Phe Val Lys Leu Leu Ile Glu Asn Gly Val Ser Met 
    370                 375                 380                 


His Arg Phe Leu Thr Ile Ser Arg Leu Glu Glu Leu Tyr Asn Thr Arg 
385                 390                 395                 400 


His Gly Pro Ser Asn Thr Leu Tyr His Leu Val Arg Asp Val Lys Lys 
                405                 410                 415     


Gly Asn Leu Pro Pro Asp Tyr Arg Ile Ser Leu Ile Asp Ile Gly Leu 
            420                 425                 430         


Val Ile Glu Tyr Leu Met Gly Gly Ala Tyr Arg Cys Asn Tyr Thr Arg 
        435                 440                 445             


Lys Arg Phe Arg Thr Leu Tyr His Asn Leu Phe Gly Pro Lys Arg Pro 
    450                 455                 460                 


Lys Ala Leu Lys Leu Leu Gly Met Glu Asp Asp Ile Pro Leu Arg Arg 
465                 470                 475                 480 


Gly Arg Lys Thr Thr Lys Lys Arg Glu Glu Glu Val Asp Ile Asp Leu 
                485                 490                 495     


Asp Asp Pro Glu Ile Asn His Phe Pro Phe Pro Phe His Glu Leu Met 
            500                 505                 510         


Val Trp Ala Val Leu Met Lys Arg Gln Lys Met Ala Leu Phe Phe Trp 
        515                 520                 525             


Gln His Gly Glu Glu Ala Met Ala Lys Ala Leu Val Ala Cys Lys Leu 
    530                 535                 540                 


Cys Lys Ala Met Ala His Glu Ala Ser Glu Asn Asp Met Val Asp Asp 
545                 550                 555                 560 


Ile Ser Gln Glu Leu Asn His Asn Ser Arg Asp Phe Gly Gln Leu Ala 
                565                 570                 575     


Val Glu Leu Leu Asp Gln Ser Tyr Lys Gln Asp Glu Gln Leu Ala Met 
            580                 585                 590         


Lys Leu Leu Thr Tyr Glu Leu Lys Asn Trp Ser Asn Ala Thr Cys Leu 
        595                 600                 605             


Gln Leu Ala Val Ala Ala Lys His Arg Asp Phe Ile Ala His Thr Cys 
    610                 615                 620                 


Ser Gln Met Leu Leu Thr Asp Met Trp Met Gly Arg Leu Arg Met Arg 
625                 630                 635                 640 


Lys Asn Ser Gly Leu Lys Val Ile Leu Gly Ile Leu Leu Pro Pro Ser 
                645                 650                 655     


Ile Leu Ser Leu Glu Phe Lys Asn Lys Asp Asp Met Pro Tyr Met Ser 
            660                 665                 670         


Gln Ala Gln Glu Ile His Leu Gln Glu Lys Glu Ala Glu Glu Pro Glu 
        675                 680                 685             


Lys Pro Thr Lys Glu Lys Glu Glu Glu Asp Met Glu Leu Thr Ala Met 
    690                 695                 700                 


Leu Gly Arg Asn Asn Gly Glu Ser Ser Arg Lys Lys Asp Glu Glu Glu 
705                 710                 715                 720 


Val Gln Ser Lys His Arg Leu Ile Pro Leu Gly Arg Lys Ile Tyr Glu 
                725                 730                 735     


Phe Tyr Asn Ala Pro Ile Val Lys Phe Trp Phe Tyr Thr Leu Ala Tyr 
            740                 745                 750         


Ile Gly Tyr Leu Met Leu Phe Asn Tyr Ile Val Leu Val Lys Met Glu 
        755                 760                 765             


Arg Trp Pro Ser Thr Gln Glu Trp Ile Val Ile Ser Tyr Ile Phe Thr 
    770                 775                 780                 


Leu Gly Ile Glu Lys Met Arg Glu Ile Leu Met Ser Glu Pro Gly Lys 
785                 790                 795                 800 


Leu Leu Gln Lys Val Lys Val Trp Leu Gln Glu Tyr Trp Asn Val Thr 
                805                 810                 815     


Asp Leu Ile Ala Ile Leu Leu Phe Ser Val Gly Met Ile Leu Arg Leu 
            820                 825                 830         


Gln Asp Gln Pro Phe Arg Ser Asp Gly Arg Val Ile Tyr Cys Val Asn 
        835                 840                 845             


Ile Ile Tyr Trp Tyr Ile Arg Leu Leu Asp Ile Phe Gly Val Asn Lys 
    850                 855                 860                 


Tyr Leu Gly Pro Tyr Val Met Met Ile Gly Lys Met Met Ile Asp Met 
865                 870                 875                 880 


Met Tyr Phe Val Ile Ile Met Leu Val Val Leu Met Ser Phe Gly Val 
                885                 890                 895     


Ala Arg Gln Ala Ile Leu Phe Pro Asn Glu Glu Pro Ser Trp Lys Leu 
            900                 905                 910         


Ala Lys Asn Ile Phe Tyr Met Pro Tyr Trp Met Ile Tyr Gly Glu Val 
        915                 920                 925             


Phe Ala Asp Gln Ile Asp Pro Pro Cys Gly Gln Asn Glu Thr Arg Glu 
    930                 935                 940                 


Asp Gly Lys Ile Ile Gln Leu Pro Pro Cys Lys Thr Gly Ala Trp Ile 
945                 950                 955                 960 


Val Pro Ala Ile Met Ala Cys Tyr Leu Leu Val Ala Asn Ile Leu Leu 
                965                 970                 975     


Val Asn Leu Leu Ile Ala Val Phe Asn Asn Thr Phe Phe Glu Val Lys 
            980                 985                 990         


Ser Ile Ser Asn Gln Val Trp Lys  Phe Gln Arg Tyr Gln  Leu Ile Met 
        995                 1000                 1005             


Thr Phe  His Glu Arg Pro Val  Leu Pro Pro Pro Leu  Ile Ile Phe 
    1010                 1015                 1020             


Ser His  Met Thr Met Ile Phe  Gln His Leu Cys Cys  Arg Trp Arg 
    1025                 1030                 1035             


Lys His  Glu Ser Asp Pro Asp  Glu Arg Asp Tyr Gly  Leu Lys Leu 
    1040                 1045                 1050             


Phe Ile  Thr Asp Asp Glu Leu  Lys Lys Val His Asp  Phe Glu Glu 
    1055                 1060                 1065             


Gln Cys  Ile Glu Glu Tyr Phe  Arg Glu Lys Asp Asp  Arg Phe Asn 
    1070                 1075                 1080             


Ser Ser  Asn Asp Glu Arg Ile  Arg Val Thr Ser Glu  Arg Val Glu 
    1085                 1090                 1095             


Asn Met  Ser Met Arg Leu Glu  Glu Val Asn Glu Arg  Glu His Ser 
    1100                 1105                 1110             


Met Lys  Ala Ser Leu Gln Thr  Val Asp Ile Arg Leu  Ala Gln Leu 
    1115                 1120                 1125             


Glu Asp  Leu Ile Gly Arg Met  Ala Thr Ala Leu Glu  Arg Leu Thr 
    1130                 1135                 1140             


Gly Leu  Glu Arg Ala Glu Ser  Asn Lys Ile Arg Ser  Arg Thr Ser 
    1145                 1150                 1155             


Ser Asp  Cys Thr Asp Ala Ala  Tyr Ile Val Arg Gln  Ser Ser Phe 
    1160                 1165                 1170             


Asn Ser  Gln Glu Gly Asn Thr  Phe Lys Leu Gln Glu  Ser Ile Asp 
    1175                 1180                 1185             


Pro Ala  Gly Glu Glu Thr Met  Ser Pro Thr Ser Pro  Thr Leu Met 
    1190                 1195                 1200             


Pro Arg  Met Arg Ser His Ser  Phe Tyr Ser Val Asn  Met Lys Asp 
    1205                 1210                 1215             


Lys Gly  Gly Ile Glu Lys Leu  Glu Ser Ile Phe Lys  Glu Arg Ser 
    1220                 1225                 1230             


Leu Ser  Leu His Arg Ala Thr  Ser Ser His Ser Val  Ala Lys Glu 
    1235                 1240                 1245             


Pro Lys  Ala Pro Ala Ala Pro  Ala Asn Thr Leu Ala  Ile Val Pro 
    1250                 1255                 1260             


Asp Ser  Arg Arg Pro Ser Ser  Cys Ile Asp Ile Tyr  Val Ser Ala 
    1265                 1270                 1275             


Met Asp  Glu Leu His Cys Asp  Ile Asp Pro Leu Asp  Asn Ser Val 
    1280                 1285                 1290             


Asn Ile  Leu Gly Leu Gly Glu  Pro Ser Phe Ser Thr  Pro Val Pro 
    1295                 1300                 1305             


Ser Thr  Ala Pro Ser Ser Ser  Ala Tyr Ala Thr Leu  Ala Pro Thr 
    1310                 1315                 1320             


Asp Arg  Pro Pro Ser Arg Ser  Ile Asp Phe Glu Asp  Ile Thr Ser 
    1325                 1330                 1335             


Met Asp  Thr Arg Ser Phe Ser  Ser Asp Tyr Thr His  Leu Pro Glu 
    1340                 1345                 1350             


Cys Gln  Asn Pro Trp Asp Ser  Glu Pro Pro Met Tyr  His Thr Ile 
    1355                 1360                 1365             


Glu Arg  Ser Lys Ser Ser Arg  Tyr Leu Ala Thr Thr  Pro Phe Leu 
    1370                 1375                 1380             


Leu Glu  Glu Ala Pro Ile Val  Lys Ser His Ser Phe  Met Phe Ser 
    1385                 1390                 1395             


Pro Ser  Arg Ser Tyr Tyr Ala  Asn Phe Gly Val Pro  Val Lys Thr 
    1400                 1405                 1410             


Ala Glu  Tyr Thr Ser Ile Thr  Asp Cys Ile Asp Thr  Arg Cys Val 
    1415                 1420                 1425             


Asn Ala  Pro Gln Ala Ile Ala  Asp Arg Ala Ala Phe  Pro Gly Gly 
    1430                 1435                 1440             


Leu Gly  Asp Lys Val Glu Asp  Leu Thr Cys Cys His  Pro Glu Arg 
    1445                 1450                 1455             


Glu Ala  Glu Leu Ser His Pro  Ser Ser Asp Ser Glu  Glu Asn Glu 
    1460                 1465                 1470             


Ala Lys  Gly Arg Arg Ala Thr  Ile Ala Ile Ser Ser  Gln Glu Gly 
    1475                 1480                 1485             


Asp Asn  Ser Glu Arg Thr Leu  Ser Asn Asn Ile Thr  Val Pro Lys 
    1490                 1495                 1500             


Ile Glu  Arg Ala Asn Ser Tyr  Ser Ala Glu Glu Pro  Ser Ala Pro 
    1505                 1510                 1515             


Tyr Ala  His Thr Arg Lys Ser  Phe Ser Ile Ser Asp  Lys Leu Asp 
    1520                 1525                 1530             


Arg Gln  Arg Asn Thr Ala Ser  Leu Arg Asn Pro Phe  Gln Arg Ser 
    1535                 1540                 1545             


Lys Ser  Ser Lys Pro Glu Gly  Arg Gly Asp Ser Leu  Ser Met Arg 
    1550                 1555                 1560             


Arg Leu  Ser Arg Thr Ser Ala  Phe Gln Ser Phe Glu  Ser Lys His 
    1565                 1570                 1575             


Asn 
    

<210>  380
<211>  5985
<212>  DNA
<213>  Homo sapiens

<400>  380
agctgcagca aaatgaaagc aacaggagct gctccgggga ctgcttttgc cagtacccag     60

aatcagtgct caggctcaga aatcctggat agaaagagca ttttataaaa gagaatgtgt    120

ccacatcata cccagcacca aagaccccca taggtgttgc tgtgggcgtc tgataggcca    180

gcatgttggc ctcaccccca gtatctccgt gcttcagaat gagaaaaatg aaagtcgcct    240

ctcccgaaat gacatccagt ctgaaaagtg gtccatcagc aaacacactc aactcagccc    300

tacggatgct tttgggacca ttgagttcca aggaggtggc cattccaaca aagccatgta    360

tgtgcgagta tcttttgata caaaacctga tctcctctta cacctgatga ccaaggaatg    420

gcagttggag cttcccaagc ttctcatctc tgtccatggg ggcctgcaga actttgaact    480

ccagccaaaa ctcaagcaag tctttgggaa agggctcatc aaagcagcaa tgacaactgg    540

agcgtggata ttcactggag gggttaacac aggtgttatt cgtcatgttg gcgatgcctt    600

gaaggatcat gcctctaagt ctcgaggaaa gatatgcacc ataggtattg ccccctgggg    660

aattgtggaa aaccaggagg acctcattgg aagagatgtt gtccggccat accagaccat    720

gtccaatccc atgagcaagc tcactgttct caacagcatg cattcccact tcattctggc    780

tgacaacggg accactggaa aatatggagc agaggtgaaa cttcgaagac aactggaaaa    840

gcatatttca ctccagaaga taaacacaag atgcctgccg tttttctctc ttgactcccg    900

cttgttttat tcattttggg gtagttgcca gttagactca gttggaatcg gtcaaggtgt    960

tcctgtggtg gcactcatag tggaaggagg acccaatgtg atctcgattg ttttggagta   1020

ccttcgagac acccctcccg tgccagtggt tgtctgtgat gggagtggac gggcatcgga   1080

catcctggcc tttgggcata aatactcaga agaaggcgga ctgataaatg aatctttgag   1140

ggaccagctg ttggtgacta tacagaagac tttcacatac actcgaaccc aagctcagca   1200

tctgttcatc atcctcatgg agtgcatgaa gaagaaggaa ttgattacgg tatttcggat   1260

gggatcagaa ggacaccagg acattgattt ggctatcctg acagctttac tcaaaggagc   1320

caatgcctcg gccccagacc aactgagctt agctttagcc tggaacagag tcgacatcgc   1380

tcgcagccag atctttattt acgggcaaca gtggccggtg ggatctctgg agcaagccat   1440

gttggatgcc ttagttctgg acagagtgga ttttgtgaaa ttactcatag agaatggagt   1500

aagcatgcac cgttttctca ccatctccag actagaggaa ttgtacaata cgagacatgg   1560

gccctcaaat acattgtacc acttggtcag ggatgtcaaa aaggggaacc tgcccccaga   1620

ctacagaatc agcctgattg acatcggcct ggtgatcgag tacctgatgg gcggggctta   1680

tcgctgcaac tacacgcgca agcgcttccg gaccctctac cacaacctct tcggccccaa   1740

gagggatgat attcccttga ggcgaggaag aaagacaacc aagaaacgtg aagaagaggt   1800

ggacattgac ttggatgatc ctgagatcaa ccacttcccc ttccctttcc atgagctcat   1860

ggtgtgggct gttctcatga agcggcagaa gatggccctg ttcttctggc agcacggtga   1920

ggaggccatg gccaaggccc tggtggcctg caagctctgc aaagccatgg ctcatgaggc   1980

ctctgagaac gacatggttg acgacatttc ccaggagctg aatcacaatt ccagagactt   2040

tggccagctg gctgtggagc tcctggacca gtcctacaag caggacgaac agctggccat   2100

gaaactgctg acgtatgagc tgaagaactg gagcaacgcc acgtgcctgc agcttgccgt   2160

ggctgccaaa caccgcgact tcatcgcgca cacgtgcagc cagatgctgc tcaccgacat   2220

gtggatgggc cggctccgca tgcgcaagaa ctcaggcctc aaggtaattc tgggaattct   2280

acttcctcct tcaattctca gcttggagtt caagaacaaa gacgacatgc cctatatgtc   2340

tcaggcccag gaaatccacc tccaagagaa ggaggcagaa gaaccagaga agcccacaaa   2400

ggaaaaagag gaagaggaca tggagctcac agcaatgttg ggacgaaaca acggggagtc   2460

ctccaggaag aaggatgaag aggaagttca gagcaagcac cggttaatcc ccctcggcag   2520

aaaaatctat gaattctaca atgcacccat cgtgaagttc tggttctaca cactggcgta   2580

tatcggatac ctgatgctct tcaactatat cgtgttagtg aagatggaac gctggccgtc   2640

cacccaggaa tggatcgtaa tctcctatat tttcaccctg ggaatagaaa agatgagaga   2700

gattctgatg tcagagccag ggaagttgct acagaaagtg aaggtatggc tgcaggagta   2760

ctggaatgtc acggacctca tcgccatcct tctgttttct gtcggaatga tccttcgtct   2820

ccaagaccag cccttcagga gtgacgggag ggtcatctac tgcgtgaaca tcatttactg   2880

gtatatccgt ctcctagaca tcttcggcgt gaacaagtat ttgggcccgt atgtaatgat   2940

gattggaaaa atgatgatag acatgatgta ctttgtcatc attatgctgg tggttctgat   3000

gagctttggg gtcgccaggc aagccatcct ttttcccaat gaggagccat catggaaact   3060

ggccaagaac atcttctaca tgccctattg gatgatttat ggggaagtgt ttgcggacca   3120

gatagaccct ccctgtggac agaatgagac ccgagaggat ggtaaaataa tccagctgcc   3180

tccctgcaag acaggagctt ggatcgtgcc ggccatcatg gcctgctacc tcttagtggc   3240

aaacatcttg ctggtcaacc tcctcattgc tgtctttaac aatacatttt ttgaagtaaa   3300

atcgatatcc aaccaagtct ggaagtttca gaggtatcag ctcatcatga ctttccatga   3360

aaggccagtt ctgcccccac cactgatcat cttcagccac atgaccatga tattccagca   3420

cctgtgctgc cgatggagga aacacgagag cgacccggat gaaagggact acggcctgaa   3480

actcttcata accgatgatg agctcaagaa agtacatgac tttgaagagc aatgcataga   3540

agaatacttc agagaaaagg atgatcggtt caactcatct aatgatgaga ggatacgggt   3600

gacttcagaa agggtggaga acatgtctat gcggctggag gaagtcaacg agagagagca   3660

ctccatgaag gcttcactcc agaccgtgga catccggctg gcgcagctgg aagaccttat   3720

cgggcgcatg gccacggccc tggagcgcct gacaggtctg gagcgggccg agtccaacaa   3780

aatccgctcg aggacctcgt cagactgcac ggacgccgcc tacattgtcc gtcagagcag   3840

cttcaacagc caggaaggga acaccttcaa gctccaagag agtatagacc ctgcaggtga   3900

ggagaccatg tccccaactt ctccaacctt aatgccccgt atgcgaagcc attctttcta   3960

ttcggtcaat atgaaagaca aaggtggtat agaaaagttg gaaagtattt ttaaagaaag   4020

gtccctgagc ctacaccggg ctactagttc ccactctgta gcaaaagaac ccaaagctcc   4080

tgcagcccct gccaacacct tggccattgt tcctgattcc agaagaccat catcgtgtat   4140

agacatctat gtctctgcta tggatgagct ccactgtgat atagaccctc tggacaattc   4200

cgtgaacatc cttgggctgg gcgagccaag cttttcaact ccagtacctt ccacagcccc   4260

ttcaagtagt gcctatgcaa cacttgcacc cacagacaga cctccaagcc ggagcattga   4320

ttttgaggac atcacctcca tggacactag atctttttct tcagactaca cccacctccc   4380

agaatgccaa aacccctggg actcagagcc tccgatgtac cacaccattg agcgttccaa   4440

aagtagccgc tacctagcca ccacaccctt tcttctagaa gaggctccca ttgtgaaatc   4500

tcatagcttt atgttttccc cctcaaggag ctattatgcc aactttgggg tgcctgtaaa   4560

aacagcagaa tacacaagta ttacagactg tattgacaca aggtgtgtca atgcccctca   4620

agcaattgcg gacagagctg ccttccctgg aggtcttgga gacaaagtgg aggacttaac   4680

ttgctgccat ccagagcgag aagcagaact gagtcacccc agctctgaca gtgaggagaa   4740

tgaggccaaa ggccgcagag ccaccattgc aatatcctcc caggagggtg ataactcaga   4800

gagaaccctg tccaacaaca tcactgttcc caagatagag cgcgccaaca gctactcggc   4860

agaggagcca agtgcgccat atgcacacac caggaagagc ttctccatca gtgacaaact   4920

cgacaggcag cggaacacag caagcctgcg aaatcccttc cagagaagca agtcctccaa   4980

gccggagggc cgaggggaca gcctgtccat gaggagactg tccagaacat cggctttcca   5040

aagctttgaa agcaagcaca actaaacctt cttaatatcc gccacagaag gctcaagaat   5100

ccagccctaa aattctctcc aactccagtt tttccccttt ccttgaatca tacctgcttt   5160

attcttagct gagcaaaaca agcaatgctt tgggaggtgt taactcaaag gtgacttctg   5220

ggccacagat caagaaagca tttgatctga cccagtgcca gacacagggg atttaaggca   5280

tgttcacact tgctgggcag ggagggggaa gagagggaga aggaagggtt agagatgaat   5340

gtgtatccgc agtcacagca gaaagccatg agagcagggg aaacaagggg cttcgagcac   5400

gctccatgcc aggaggcatc tgttgatttc tgaccattat caagagttgt aggatgcagg   5460

gctaaattgc aaaataaaat aaaatagcca gcgtacacaa tgagatattc taaacttcca   5520

ttctgttttc ttttcacatt ggctccatca ctggtgactg atgaagagca tcctctttat   5580

tcagtataag ccggcagcaa gcagttctac ctaacgtccc acatccttct catgccaaca   5640

cttctgtaat tgatcattat aaagaaaaaa caaggtaaca gtcatagttc acctgtctct   5700

tatctattca cttctggtgc cacaactgtt tatccttttt tgaagaaaat aagggaacag   5760

aaatgccttt ttgtattgca atcgaaatga aagaagagtt gatgttaaaa aaacaaaagt   5820

caagtgattt attatataca gtgggcgttc aagtctagtc gagcaagctc aggagaatgt   5880

aattaaataa ttttatattt tttaatttat tttgtatctc acctgtcatg gatgaattca   5940

ttcactgaat atgtaatatt gaacttaaaa aaaaaaaaaa aaaaa                   5985


<210>  381
<211>  1569
<212>  PRT
<213>  Homo sapiens

<400>  381


Met Tyr Val Arg Val Ser Phe Asp Thr Lys Pro Asp Leu Leu Leu His 
1               5                   10                  15      


Leu Met Thr Lys Glu Trp Gln Leu Glu Leu Pro Lys Leu Leu Ile Ser 
            20                  25                  30          


Val His Gly Gly Leu Gln Asn Phe Glu Leu Gln Pro Lys Leu Lys Gln 
        35                  40                  45              


Val Phe Gly Lys Gly Leu Ile Lys Ala Ala Met Thr Thr Gly Ala Trp 
    50                  55                  60                  


Ile Phe Thr Gly Gly Val Asn Thr Gly Val Ile Arg His Val Gly Asp 
65                  70                  75                  80  


Ala Leu Lys Asp His Ala Ser Lys Ser Arg Gly Lys Ile Cys Thr Ile 
                85                  90                  95      


Gly Ile Ala Pro Trp Gly Ile Val Glu Asn Gln Glu Asp Leu Ile Gly 
            100                 105                 110         


Arg Asp Val Val Arg Pro Tyr Gln Thr Met Ser Asn Pro Met Ser Lys 
        115                 120                 125             


Leu Thr Val Leu Asn Ser Met His Ser His Phe Ile Leu Ala Asp Asn 
    130                 135                 140                 


Gly Thr Thr Gly Lys Tyr Gly Ala Glu Val Lys Leu Arg Arg Gln Leu 
145                 150                 155                 160 


Glu Lys His Ile Ser Leu Gln Lys Ile Asn Thr Arg Cys Leu Pro Phe 
                165                 170                 175     


Phe Ser Leu Asp Ser Arg Leu Phe Tyr Ser Phe Trp Gly Ser Cys Gln 
            180                 185                 190         


Leu Asp Ser Val Gly Ile Gly Gln Gly Val Pro Val Val Ala Leu Ile 
        195                 200                 205             


Val Glu Gly Gly Pro Asn Val Ile Ser Ile Val Leu Glu Tyr Leu Arg 
    210                 215                 220                 


Asp Thr Pro Pro Val Pro Val Val Val Cys Asp Gly Ser Gly Arg Ala 
225                 230                 235                 240 


Ser Asp Ile Leu Ala Phe Gly His Lys Tyr Ser Glu Glu Gly Gly Leu 
                245                 250                 255     


Ile Asn Glu Ser Leu Arg Asp Gln Leu Leu Val Thr Ile Gln Lys Thr 
            260                 265                 270         


Phe Thr Tyr Thr Arg Thr Gln Ala Gln His Leu Phe Ile Ile Leu Met 
        275                 280                 285             


Glu Cys Met Lys Lys Lys Glu Leu Ile Thr Val Phe Arg Met Gly Ser 
    290                 295                 300                 


Glu Gly His Gln Asp Ile Asp Leu Ala Ile Leu Thr Ala Leu Leu Lys 
305                 310                 315                 320 


Gly Ala Asn Ala Ser Ala Pro Asp Gln Leu Ser Leu Ala Leu Ala Trp 
                325                 330                 335     


Asn Arg Val Asp Ile Ala Arg Ser Gln Ile Phe Ile Tyr Gly Gln Gln 
            340                 345                 350         


Trp Pro Val Gly Ser Leu Glu Gln Ala Met Leu Asp Ala Leu Val Leu 
        355                 360                 365             


Asp Arg Val Asp Phe Val Lys Leu Leu Ile Glu Asn Gly Val Ser Met 
    370                 375                 380                 


His Arg Phe Leu Thr Ile Ser Arg Leu Glu Glu Leu Tyr Asn Thr Arg 
385                 390                 395                 400 


His Gly Pro Ser Asn Thr Leu Tyr His Leu Val Arg Asp Val Lys Lys 
                405                 410                 415     


Gly Asn Leu Pro Pro Asp Tyr Arg Ile Ser Leu Ile Asp Ile Gly Leu 
            420                 425                 430         


Val Ile Glu Tyr Leu Met Gly Gly Ala Tyr Arg Cys Asn Tyr Thr Arg 
        435                 440                 445             


Lys Arg Phe Arg Thr Leu Tyr His Asn Leu Phe Gly Pro Lys Arg Asp 
    450                 455                 460                 


Asp Ile Pro Leu Arg Arg Gly Arg Lys Thr Thr Lys Lys Arg Glu Glu 
465                 470                 475                 480 


Glu Val Asp Ile Asp Leu Asp Asp Pro Glu Ile Asn His Phe Pro Phe 
                485                 490                 495     


Pro Phe His Glu Leu Met Val Trp Ala Val Leu Met Lys Arg Gln Lys 
            500                 505                 510         


Met Ala Leu Phe Phe Trp Gln His Gly Glu Glu Ala Met Ala Lys Ala 
        515                 520                 525             


Leu Val Ala Cys Lys Leu Cys Lys Ala Met Ala His Glu Ala Ser Glu 
    530                 535                 540                 


Asn Asp Met Val Asp Asp Ile Ser Gln Glu Leu Asn His Asn Ser Arg 
545                 550                 555                 560 


Asp Phe Gly Gln Leu Ala Val Glu Leu Leu Asp Gln Ser Tyr Lys Gln 
                565                 570                 575     


Asp Glu Gln Leu Ala Met Lys Leu Leu Thr Tyr Glu Leu Lys Asn Trp 
            580                 585                 590         


Ser Asn Ala Thr Cys Leu Gln Leu Ala Val Ala Ala Lys His Arg Asp 
        595                 600                 605             


Phe Ile Ala His Thr Cys Ser Gln Met Leu Leu Thr Asp Met Trp Met 
    610                 615                 620                 


Gly Arg Leu Arg Met Arg Lys Asn Ser Gly Leu Lys Val Ile Leu Gly 
625                 630                 635                 640 


Ile Leu Leu Pro Pro Ser Ile Leu Ser Leu Glu Phe Lys Asn Lys Asp 
                645                 650                 655     


Asp Met Pro Tyr Met Ser Gln Ala Gln Glu Ile His Leu Gln Glu Lys 
            660                 665                 670         


Glu Ala Glu Glu Pro Glu Lys Pro Thr Lys Glu Lys Glu Glu Glu Asp 
        675                 680                 685             


Met Glu Leu Thr Ala Met Leu Gly Arg Asn Asn Gly Glu Ser Ser Arg 
    690                 695                 700                 


Lys Lys Asp Glu Glu Glu Val Gln Ser Lys His Arg Leu Ile Pro Leu 
705                 710                 715                 720 


Gly Arg Lys Ile Tyr Glu Phe Tyr Asn Ala Pro Ile Val Lys Phe Trp 
                725                 730                 735     


Phe Tyr Thr Leu Ala Tyr Ile Gly Tyr Leu Met Leu Phe Asn Tyr Ile 
            740                 745                 750         


Val Leu Val Lys Met Glu Arg Trp Pro Ser Thr Gln Glu Trp Ile Val 
        755                 760                 765             


Ile Ser Tyr Ile Phe Thr Leu Gly Ile Glu Lys Met Arg Glu Ile Leu 
    770                 775                 780                 


Met Ser Glu Pro Gly Lys Leu Leu Gln Lys Val Lys Val Trp Leu Gln 
785                 790                 795                 800 


Glu Tyr Trp Asn Val Thr Asp Leu Ile Ala Ile Leu Leu Phe Ser Val 
                805                 810                 815     


Gly Met Ile Leu Arg Leu Gln Asp Gln Pro Phe Arg Ser Asp Gly Arg 
            820                 825                 830         


Val Ile Tyr Cys Val Asn Ile Ile Tyr Trp Tyr Ile Arg Leu Leu Asp 
        835                 840                 845             


Ile Phe Gly Val Asn Lys Tyr Leu Gly Pro Tyr Val Met Met Ile Gly 
    850                 855                 860                 


Lys Met Met Ile Asp Met Met Tyr Phe Val Ile Ile Met Leu Val Val 
865                 870                 875                 880 


Leu Met Ser Phe Gly Val Ala Arg Gln Ala Ile Leu Phe Pro Asn Glu 
                885                 890                 895     


Glu Pro Ser Trp Lys Leu Ala Lys Asn Ile Phe Tyr Met Pro Tyr Trp 
            900                 905                 910         


Met Ile Tyr Gly Glu Val Phe Ala Asp Gln Ile Asp Pro Pro Cys Gly 
        915                 920                 925             


Gln Asn Glu Thr Arg Glu Asp Gly Lys Ile Ile Gln Leu Pro Pro Cys 
    930                 935                 940                 


Lys Thr Gly Ala Trp Ile Val Pro Ala Ile Met Ala Cys Tyr Leu Leu 
945                 950                 955                 960 


Val Ala Asn Ile Leu Leu Val Asn Leu Leu Ile Ala Val Phe Asn Asn 
                965                 970                 975     


Thr Phe Phe Glu Val Lys Ser Ile Ser Asn Gln Val Trp Lys Phe Gln 
            980                 985                 990         


Arg Tyr Gln Leu Ile Met Thr Phe  His Glu Arg Pro Val  Leu Pro Pro 
        995                 1000                 1005             


Pro Leu  Ile Ile Phe Ser His  Met Thr Met Ile Phe  Gln His Leu 
    1010                 1015                 1020             


Cys Cys  Arg Trp Arg Lys His  Glu Ser Asp Pro Asp  Glu Arg Asp 
    1025                 1030                 1035             


Tyr Gly  Leu Lys Leu Phe Ile  Thr Asp Asp Glu Leu  Lys Lys Val 
    1040                 1045                 1050             


His Asp  Phe Glu Glu Gln Cys  Ile Glu Glu Tyr Phe  Arg Glu Lys 
    1055                 1060                 1065             


Asp Asp  Arg Phe Asn Ser Ser  Asn Asp Glu Arg Ile  Arg Val Thr 
    1070                 1075                 1080             


Ser Glu  Arg Val Glu Asn Met  Ser Met Arg Leu Glu  Glu Val Asn 
    1085                 1090                 1095             


Glu Arg  Glu His Ser Met Lys  Ala Ser Leu Gln Thr  Val Asp Ile 
    1100                 1105                 1110             


Arg Leu  Ala Gln Leu Glu Asp  Leu Ile Gly Arg Met  Ala Thr Ala 
    1115                 1120                 1125             


Leu Glu  Arg Leu Thr Gly Leu  Glu Arg Ala Glu Ser  Asn Lys Ile 
    1130                 1135                 1140             


Arg Ser  Arg Thr Ser Ser Asp  Cys Thr Asp Ala Ala  Tyr Ile Val 
    1145                 1150                 1155             


Arg Gln  Ser Ser Phe Asn Ser  Gln Glu Gly Asn Thr  Phe Lys Leu 
    1160                 1165                 1170             


Gln Glu  Ser Ile Asp Pro Ala  Gly Glu Glu Thr Met  Ser Pro Thr 
    1175                 1180                 1185             


Ser Pro  Thr Leu Met Pro Arg  Met Arg Ser His Ser  Phe Tyr Ser 
    1190                 1195                 1200             


Val Asn  Met Lys Asp Lys Gly  Gly Ile Glu Lys Leu  Glu Ser Ile 
    1205                 1210                 1215             


Phe Lys  Glu Arg Ser Leu Ser  Leu His Arg Ala Thr  Ser Ser His 
    1220                 1225                 1230             


Ser Val  Ala Lys Glu Pro Lys  Ala Pro Ala Ala Pro  Ala Asn Thr 
    1235                 1240                 1245             


Leu Ala  Ile Val Pro Asp Ser  Arg Arg Pro Ser Ser  Cys Ile Asp 
    1250                 1255                 1260             


Ile Tyr  Val Ser Ala Met Asp  Glu Leu His Cys Asp  Ile Asp Pro 
    1265                 1270                 1275             


Leu Asp  Asn Ser Val Asn Ile  Leu Gly Leu Gly Glu  Pro Ser Phe 
    1280                 1285                 1290             


Ser Thr  Pro Val Pro Ser Thr  Ala Pro Ser Ser Ser  Ala Tyr Ala 
    1295                 1300                 1305             


Thr Leu  Ala Pro Thr Asp Arg  Pro Pro Ser Arg Ser  Ile Asp Phe 
    1310                 1315                 1320             


Glu Asp  Ile Thr Ser Met Asp  Thr Arg Ser Phe Ser  Ser Asp Tyr 
    1325                 1330                 1335             


Thr His  Leu Pro Glu Cys Gln  Asn Pro Trp Asp Ser  Glu Pro Pro 
    1340                 1345                 1350             


Met Tyr  His Thr Ile Glu Arg  Ser Lys Ser Ser Arg  Tyr Leu Ala 
    1355                 1360                 1365             


Thr Thr  Pro Phe Leu Leu Glu  Glu Ala Pro Ile Val  Lys Ser His 
    1370                 1375                 1380             


Ser Phe  Met Phe Ser Pro Ser  Arg Ser Tyr Tyr Ala  Asn Phe Gly 
    1385                 1390                 1395             


Val Pro  Val Lys Thr Ala Glu  Tyr Thr Ser Ile Thr  Asp Cys Ile 
    1400                 1405                 1410             


Asp Thr  Arg Cys Val Asn Ala  Pro Gln Ala Ile Ala  Asp Arg Ala 
    1415                 1420                 1425             


Ala Phe  Pro Gly Gly Leu Gly  Asp Lys Val Glu Asp  Leu Thr Cys 
    1430                 1435                 1440             


Cys His  Pro Glu Arg Glu Ala  Glu Leu Ser His Pro  Ser Ser Asp 
    1445                 1450                 1455             


Ser Glu  Glu Asn Glu Ala Lys  Gly Arg Arg Ala Thr  Ile Ala Ile 
    1460                 1465                 1470             


Ser Ser  Gln Glu Gly Asp Asn  Ser Glu Arg Thr Leu  Ser Asn Asn 
    1475                 1480                 1485             


Ile Thr  Val Pro Lys Ile Glu  Arg Ala Asn Ser Tyr  Ser Ala Glu 
    1490                 1495                 1500             


Glu Pro  Ser Ala Pro Tyr Ala  His Thr Arg Lys Ser  Phe Ser Ile 
    1505                 1510                 1515             


Ser Asp  Lys Leu Asp Arg Gln  Arg Asn Thr Ala Ser  Leu Arg Asn 
    1520                 1525                 1530             


Pro Phe  Gln Arg Ser Lys Ser  Ser Lys Pro Glu Gly  Arg Gly Asp 
    1535                 1540                 1545             


Ser Leu  Ser Met Arg Arg Leu  Ser Arg Thr Ser Ala  Phe Gln Ser 
    1550                 1555                 1560             


Phe Glu  Ser Lys His Asn 
    1565                 

<210>  382
<211>  1303
<212>  DNA
<213>  Homo sapiens

<400>  382
agctgcagca aaatgaaagc aacaggagct gctccgggga ctgcttttgc cagtacccag     60

aatcagtgct caggctcaga aatcctggat agaaagagca ttttataaaa gagaatgtgt    120

ccacatcata cccagcacca aagaccccca taggtgttgc tgtgggcgtc tgataggcca    180

gcatgttggc ctcaccccca gtatctccgt gcttcagaat gagaaaaatg aaagtcgcct    240

ctcccgaaat gacatccagt ctgaaaagtg gtccatcagc aaacacactc aactcagccc    300

tacggatgct tttgggacca ttgagttcca aggaggtggc cattccaaca aagccatgta    360

tgtgcgagta tcttttgata caaaacctga tctcctctta cacctgatga ccaaggaatg    420

gcagttggag cttcccaagc ttctcatctc tgtccatggg ggcctgcaga actttgaact    480

ccagccaaaa ctcaagcaag tctttgggaa agggctcatc aaagcagcaa tgacaactgg    540

agcgtggata ttcactggag gggttaacac aggtgttatt cgtcatgttg gcgatgcctt    600

gaaggatcat gcctctaagt ctcgaggaaa gatatgcacc ataggtattg ccccctgggg    660

aattgtggaa aaccaggagg acctcattgg aagagatgtt gtccggccat accagaccat    720

gtccaatccc atgagcaagc tcactgttct caacagcatg cattcccact tcattctggc    780

tgacaacggg accactggaa aatatggagc agaggtgaaa cttcgaagac aactggaaaa    840

gcatatttca ctccagaaga taaacacaag aatcggtcaa ggtgttcctg tggtggcact    900

catagtggaa ggaggaccca atgtgatctc gattgttttg gagtaccttc gagacacccc    960

tcccgtgcca gtggttgtct gtgatgggag tggacgggca tcggacatcc tggcctttgg   1020

gcataaatac tcagaagaag gcgggtaggt aactttccag gccccatgga agaaccctaa   1080

agcctgtttg gaaacgaggg tatgagtgga ttatgttttc agtagctcaa ccaagacctc   1140

aaatcaaaac aagctatgaa caaattgtct aaaaaatgtc tgtcatggga gggctgtggt   1200

gaagaacaga gaaacatatt ctaaatgtcc tgtgaagtgg gaaattctat gaaagctaca   1260

cggataataa aaagggtgag gaaaagaaaa aaaaaaaaaa aaa                     1303


<210>  383
<211>  230
<212>  PRT
<213>  Homo sapiens

<400>  383


Met Tyr Val Arg Val Ser Phe Asp Thr Lys Pro Asp Leu Leu Leu His 
1               5                   10                  15      


Leu Met Thr Lys Glu Trp Gln Leu Glu Leu Pro Lys Leu Leu Ile Ser 
            20                  25                  30          


Val His Gly Gly Leu Gln Asn Phe Glu Leu Gln Pro Lys Leu Lys Gln 
        35                  40                  45              


Val Phe Gly Lys Gly Leu Ile Lys Ala Ala Met Thr Thr Gly Ala Trp 
    50                  55                  60                  


Ile Phe Thr Gly Gly Val Asn Thr Gly Val Ile Arg His Val Gly Asp 
65                  70                  75                  80  


Ala Leu Lys Asp His Ala Ser Lys Ser Arg Gly Lys Ile Cys Thr Ile 
                85                  90                  95      


Gly Ile Ala Pro Trp Gly Ile Val Glu Asn Gln Glu Asp Leu Ile Gly 
            100                 105                 110         


Arg Asp Val Val Arg Pro Tyr Gln Thr Met Ser Asn Pro Met Ser Lys 
        115                 120                 125             


Leu Thr Val Leu Asn Ser Met His Ser His Phe Ile Leu Ala Asp Asn 
    130                 135                 140                 


Gly Thr Thr Gly Lys Tyr Gly Ala Glu Val Lys Leu Arg Arg Gln Leu 
145                 150                 155                 160 


Glu Lys His Ile Ser Leu Gln Lys Ile Asn Thr Arg Ile Gly Gln Gly 
                165                 170                 175     


Val Pro Val Val Ala Leu Ile Val Glu Gly Gly Pro Asn Val Ile Ser 
            180                 185                 190         


Ile Val Leu Glu Tyr Leu Arg Asp Thr Pro Pro Val Pro Val Val Val 
        195                 200                 205             


Cys Asp Gly Ser Gly Arg Ala Ser Asp Ile Leu Ala Phe Gly His Lys 
    210                 215                 220                 


Tyr Ser Glu Glu Gly Gly 
225                 230 

<210>  384
<211>  2209
<212>  DNA
<213>  Homo sapiens

<400>  384
ctaaatgaag agcgcttggg acctgaacaa ccagcagcga tacccaggta caaaggacct     60

ccagaccaga gccagccagc agcaaaaaga gcatggagct gaggagtaca gcagccccca    120

gagctgaggg ctacagcaac gtgggcttcc agaatgaaga aaactttctt gagaacgaga    180

acacatcagg aaacaactca ataagaagca gagctgtgca aagcagggag cacacaaaca    240

ccaaacagga tgaagaacag gtcacagttg agcaggattc tccaagaaac agagaacaca    300

tggaggatga tgatgaggag atgcaacaaa aagggtgttt ggaaaggagg tatgacacag    360

tatgtggttt ctgtaggaaa cacaaaacaa ctcttcggca catcatctgg ggcattttat    420

tagcaggtta tctggttatg gtgatttcgg cctgtgtgct gaactttcac agagcccttc    480

ctctttttgt gatcaccgtg gctgccatct tctttgttgt ctgggatcac ctgatggcca    540

aatacgaaca tcgaattgat gagatgctgt ctcctggcag aaggcttcta aacagccatt    600

ggttctggct gaagtgggtg atctggagct ccctggtcct agcagttatt ttctggttgg    660

cctttgacac tgccaaattg ggtcaacagc agctggtgtc cttcggtggg ctcataatgt    720

acattgtcct gttatttcta ttttccaagt acccaaccag agtttactgg agacctgtct    780

tatggggaat cgggctacag tttcttcttg ggctcttgat tctaaggact gaccctggat    840

ttatagcttt tgattggttg ggcagacaag ttcagacttt tctggagtac acagatgctg    900

gtgcttcatt tgtctttggt gagaaataca aagaccactt ctttgcattt aaggtcctgc    960

cgatcgtggt tttcttcagc actgtgatgt ccatgctgta ctacctggga ctgatgcagt   1020

ggattattag aaaggttgga tggatcatgc tagttactac gggatcatct cctattgaat   1080

ctgtagttgc ttctggcaat atatttgttg gacaaacgga gtctccactg ctggtccgac   1140

catatttacc ttacatcacc aagtctgaac tccacgccat catgaccgcc gggttctcta   1200

ccattgctgg aagcgtgcta ggtgcataca tttcttttgg ggttccatcc tcccacttgt   1260

taacagcgtc agttatgtca gcacctgcgt cattggctgc tgctaaactc ttttggcctg   1320

agacagaaaa acctaaaata accctcaaga atgccatgaa aatggaaagt ggtgattcag   1380

ggaatcttct agaagctgca acacagggag catcctcctc catctccctg gtggccaaca   1440

tcgctgtgaa tctgattgcc ttcctggccc tgctgtcttt tatgaattca gccctgtcct   1500

ggtttggaaa catgtttgac tacccacagc tgagttttga gctaatctgc tcctacatct   1560

tcatgccctt ttccttcatg atgggagtgg aatggcagga cagctttatg gttgccagac   1620

tcataggtta taagaccttc ttcaatgaat ttgtggctta tgagcacctc tcaaaatgga   1680

tccacttgag gaaagaaggt ggacccaaat ttgtaaacgg tgtgcagcaa tatatatcaa   1740

ttcgttctga gataatcgcc acttacgctc tctgtggttt tgccaatatc gggtccctag   1800

gaatcgtgat cggcggactc acatccatgg ctccttccag aaagcgtgat atcgcctcgg   1860

gggcagtgag agctctgatt gcggggaccg tggcctgctt catgacagcc tgcatcgcag   1920

gcatactctc cagcactcct gtggacatca actgccatca cgttttagag aatgccttca   1980

actccacttt ccctggaaac acaaccaagg tgatagcttg ttgccaaagt ctgttgagca   2040

gcactgttgc caagggtcct ggtgaagtca tcccaggagg aaaccacagt ctgtattctt   2100

tgaagggctg ctgcacattg ttgaatccat cgacctttaa ctgcaatggg atctctaata   2160

cattttgagg tcagccactt ctccagtgga actctgaagt acagatgct               2209


<210>  385
<211>  691
<212>  PRT
<213>  Homo sapiens

<400>  385


Met Glu Leu Arg Ser Thr Ala Ala Pro Arg Ala Glu Gly Tyr Ser Asn 
1               5                   10                  15      


Val Gly Phe Gln Asn Glu Glu Asn Phe Leu Glu Asn Glu Asn Thr Ser 
            20                  25                  30          


Gly Asn Asn Ser Ile Arg Ser Arg Ala Val Gln Ser Arg Glu His Thr 
        35                  40                  45              


Asn Thr Lys Gln Asp Glu Glu Gln Val Thr Val Glu Gln Asp Ser Pro 
    50                  55                  60                  


Arg Asn Arg Glu His Met Glu Asp Asp Asp Glu Glu Met Gln Gln Lys 
65                  70                  75                  80  


Gly Cys Leu Glu Arg Arg Tyr Asp Thr Val Cys Gly Phe Cys Arg Lys 
                85                  90                  95      


His Lys Thr Thr Leu Arg His Ile Ile Trp Gly Ile Leu Leu Ala Gly 
            100                 105                 110         


Tyr Leu Val Met Val Ile Ser Ala Cys Val Leu Asn Phe His Arg Ala 
        115                 120                 125             


Leu Pro Leu Phe Val Ile Thr Val Ala Ala Ile Phe Phe Val Val Trp 
    130                 135                 140                 


Asp His Leu Met Ala Lys Tyr Glu His Arg Ile Asp Glu Met Leu Ser 
145                 150                 155                 160 


Pro Gly Arg Arg Leu Leu Asn Ser His Trp Phe Trp Leu Lys Trp Val 
                165                 170                 175     


Ile Trp Ser Ser Leu Val Leu Ala Val Ile Phe Trp Leu Ala Phe Asp 
            180                 185                 190         


Thr Ala Lys Leu Gly Gln Gln Gln Leu Val Ser Phe Gly Gly Leu Ile 
        195                 200                 205             


Met Tyr Ile Val Leu Leu Phe Leu Phe Ser Lys Tyr Pro Thr Arg Val 
    210                 215                 220                 


Tyr Trp Arg Pro Val Leu Trp Gly Ile Gly Leu Gln Phe Leu Leu Gly 
225                 230                 235                 240 


Leu Leu Ile Leu Arg Thr Asp Pro Gly Phe Ile Ala Phe Asp Trp Leu 
                245                 250                 255     


Gly Arg Gln Val Gln Thr Phe Leu Glu Tyr Thr Asp Ala Gly Ala Ser 
            260                 265                 270         


Phe Val Phe Gly Glu Lys Tyr Lys Asp His Phe Phe Ala Phe Lys Val 
        275                 280                 285             


Leu Pro Ile Val Val Phe Phe Ser Thr Val Met Ser Met Leu Tyr Tyr 
    290                 295                 300                 


Leu Gly Leu Met Gln Trp Ile Ile Arg Lys Val Gly Trp Ile Met Leu 
305                 310                 315                 320 


Val Thr Thr Gly Ser Ser Pro Ile Glu Ser Val Val Ala Ser Gly Asn 
                325                 330                 335     


Ile Phe Val Gly Gln Thr Glu Ser Pro Leu Leu Val Arg Pro Tyr Leu 
            340                 345                 350         


Pro Tyr Ile Thr Lys Ser Glu Leu His Ala Ile Met Thr Ala Gly Phe 
        355                 360                 365             


Ser Thr Ile Ala Gly Ser Val Leu Gly Ala Tyr Ile Ser Phe Gly Val 
    370                 375                 380                 


Pro Ser Ser His Leu Leu Thr Ala Ser Val Met Ser Ala Pro Ala Ser 
385                 390                 395                 400 


Leu Ala Ala Ala Lys Leu Phe Trp Pro Glu Thr Glu Lys Pro Lys Ile 
                405                 410                 415     


Thr Leu Lys Asn Ala Met Lys Met Glu Ser Gly Asp Ser Gly Asn Leu 
            420                 425                 430         


Leu Glu Ala Ala Thr Gln Gly Ala Ser Ser Ser Ile Ser Leu Val Ala 
        435                 440                 445             


Asn Ile Ala Val Asn Leu Ile Ala Phe Leu Ala Leu Leu Ser Phe Met 
    450                 455                 460                 


Asn Ser Ala Leu Ser Trp Phe Gly Asn Met Phe Asp Tyr Pro Gln Leu 
465                 470                 475                 480 


Ser Phe Glu Leu Ile Cys Ser Tyr Ile Phe Met Pro Phe Ser Phe Met 
                485                 490                 495     


Met Gly Val Glu Trp Gln Asp Ser Phe Met Val Ala Arg Leu Ile Gly 
            500                 505                 510         


Tyr Lys Thr Phe Phe Asn Glu Phe Val Ala Tyr Glu His Leu Ser Lys 
        515                 520                 525             


Trp Ile His Leu Arg Lys Glu Gly Gly Pro Lys Phe Val Asn Gly Val 
    530                 535                 540                 


Gln Gln Tyr Ile Ser Ile Arg Ser Glu Ile Ile Ala Thr Tyr Ala Leu 
545                 550                 555                 560 


Cys Gly Phe Ala Asn Ile Gly Ser Leu Gly Ile Val Ile Gly Gly Leu 
                565                 570                 575     


Thr Ser Met Ala Pro Ser Arg Lys Arg Asp Ile Ala Ser Gly Ala Val 
            580                 585                 590         


Arg Ala Leu Ile Ala Gly Thr Val Ala Cys Phe Met Thr Ala Cys Ile 
        595                 600                 605             


Ala Gly Ile Leu Ser Ser Thr Pro Val Asp Ile Asn Cys His His Val 
    610                 615                 620                 


Leu Glu Asn Ala Phe Asn Ser Thr Phe Pro Gly Asn Thr Thr Lys Val 
625                 630                 635                 640 


Ile Ala Cys Cys Gln Ser Leu Leu Ser Ser Thr Val Ala Lys Gly Pro 
                645                 650                 655     


Gly Glu Val Ile Pro Gly Gly Asn His Ser Leu Tyr Ser Leu Lys Gly 
            660                 665                 670         


Cys Cys Thr Leu Leu Asn Pro Ser Thr Phe Asn Cys Asn Gly Ile Ser 
        675                 680                 685             


Asn Thr Phe 
    690     

<210>  386
<211>  1791
<212>  DNA
<213>  Homo sapiens

<400>  386
gatccgtgcg gccagggtag ctatcgcggc ggcggcggcg gcggcggttg aactgactcg     60

gagcgaggag acccgagcga gcagacgcgg ccctggcgcc cgccctgcgc actcaccatg    120

gcgatgcatt tcatcttctc agatacagcg gtgcttctgt ttgatttctg gagtgtccac    180

agtcctgctg gcatggccct ttcggtgttg gtgctcctgc ttctggctgt actgtatgaa    240

ggcatcaagg ttggcaaagc caagctgctc aaccaggtac tggtgaacct gccaacctcc    300

atcagccagc agaccatcgc agagacagac ggggactctg caggctcaga ttcattccct    360

gttggcagaa cccaccacag gtggtatttg tgtcactttg gccagtctct aatccatgtc    420

atccaggtgg tcatcggcta cttcatcatg ctggccgtaa tgtcctacaa cacctggatt    480

ttccttggtg tggtcttggg ctctgctgtg ggctactacc tagcttaccc acttctcagc    540

acagcttagc tggtgaggaa cgtgcaggca ctgaggctgg agggacatgg agccccctct    600

tccagacact atacttccaa ctgccctttc ttctgatggc tattcctcca ccttattccc    660

agcccctgga aactttgagc tgaagccagc acttgctccc tggagttcgg aagccattgc    720

agcaaccttc cttctcagcc agcctacgta gggcccaggc atggtcttgt gtcttaagac    780

agctgctgtg accaaaggga gaatggagat aacaggggtg gcagggttac tgagcccatg    840

acaatgcttc tctgtgactc aaaccaggaa tttccaaaga tttcaagcca gggagaaggg    900

ttcttggtga tgcagggcat ggaacctgga caccctcagc tctcctgctt tgtgccttat    960

ctacaggagc atcgcccatt ggacttcctg acctcttctg tctttgaggg acagagacca   1020

agctagatcc tttttctcac ctttctgcct ttggaacaca tgaagatcat ctcgtctatg   1080

gatcatgttg acaaactaag ttttttttat ttttcccatt gaactcctag ttggcaattt   1140

tgcacattca tacaaaaaaa tttttaatga aatgatttca ttgattcatg atggatggca   1200

gaaactgctg agacctattt ccctttcttg gggagagaat aagtgacagc tgattaaagg   1260

cagagacaca ggactgcttt caggctcctg gtttattctc tgatagactg agctccttcc   1320

accagaaggc actgcctgca ggaagaagat gatctgatgg ccgtgggtgt ctgggaagct   1380

cttcgtggcc tcaatgccct cctttatcct catctttctt ctatgcagaa caaaaagctg   1440

catctaataa tgttcaatac ttaatattct ctatttatta cttactgctt actcgtaatg   1500

atctagtggg gaaacatgat tcattcactt aaaatactga ttaagccatg ggcaggtact   1560

gactgaagat gcaatccaac caaagccatt acattttttg agttagatgg gactctctgg   1620

atagttgaac ctcttcactt tataaaaaag gaaagagaga aaatcactgc tgtatactaa   1680

atacctcaca gattagatga aaagatggtt gtaagctttg ggaattaaaa acaaacaaat   1740

acattttagt aaatatatat ttttaaatag tctaaaaaaa aaaaaaaaaa a            1791


<210>  387
<211>  143
<212>  PRT
<213>  Homo sapiens

<400>  387


Met Ala Met His Phe Ile Phe Ser Asp Thr Ala Val Leu Leu Phe Asp 
1               5                   10                  15      


Phe Trp Ser Val His Ser Pro Ala Gly Met Ala Leu Ser Val Leu Val 
            20                  25                  30          


Leu Leu Leu Leu Ala Val Leu Tyr Glu Gly Ile Lys Val Gly Lys Ala 
        35                  40                  45              


Lys Leu Leu Asn Gln Val Leu Val Asn Leu Pro Thr Ser Ile Ser Gln 
    50                  55                  60                  


Gln Thr Ile Ala Glu Thr Asp Gly Asp Ser Ala Gly Ser Asp Ser Phe 
65                  70                  75                  80  


Pro Val Gly Arg Thr His His Arg Trp Tyr Leu Cys His Phe Gly Gln 
                85                  90                  95      


Ser Leu Ile His Val Ile Gln Val Val Ile Gly Tyr Phe Ile Met Leu 
            100                 105                 110         


Ala Val Met Ser Tyr Asn Thr Trp Ile Phe Leu Gly Val Val Leu Gly 
        115                 120                 125             


Ser Ala Val Gly Tyr Tyr Leu Ala Tyr Pro Leu Leu Ser Thr Ala 
    130                 135                 140             

<210>  388
<211>  6659
<212>  DNA
<213>  Homo sapiens

<400>  388
ccgggcggtt ggcgtcctct gcggctcctg ccaggggcgg gcttttcaaa tcttcccttt     60

gaaggagtgg cgacggcccg gacagttcgc gttggagatg gaggggccga gcctgagggg    120

tcctgcgctc cgcctggcgg ggcttcccac ccagcaggac tgcaacattc aagaaaaaat    180

agacttagaa attcgaatgc gagaaggaat atggaaactc ctttctctga gcactcagaa    240

agatcaagtt ttacatgcag ttaagaatct catggtgtgc aatgctcgac taatggccta    300

tacatcggag ctacagaaat tagaagaaca gattgcaaat cagactggaa gatgtgatgt    360

gaaatttgaa agtaaagaac gaacagcatg taaaggaaag attgccatat cagatattcg    420

aataccacta atgtggaaag actctgatca cttcagcaat aaagaacgat cacgacgcta    480

tgccattttt tgtttattca aaatgggagc taatgtgttt gatactgatg tggtgaatgt    540

ggataaaaca atcacagata tatgttttga aaatgtaacc atatttaatg aagcagggcc    600

agactttcag ataaaggtgg aagtgtatag ttgctgtaca gaagaatctt ctataaccaa    660

cacaccaaaa aagctagcta agaaactcaa gacatctata agtaaagcta caggaaagaa    720

aataagttca gtgcttcaag aagaggatga tgaaatgtgc ttgctcctca gctctgctgt    780

ttttggtgta aagtataatt tgctagctca cactacccta accttggaaa gtgctgagga    840

tagtttcaag acccataatc tgtctattaa tggaaatgag gagtcttcat tttggcttcc    900

cctgtatggc aacatgtgct gccgactagt tgcccagcca gcttgtatgg ctgaggatgc    960

atttgcagga tttcttaatc agcagcaaat ggtagaaggt ctgattagtt ggagaaggtt   1020

gtattgtgtt ttgcgaggag gtaaactcta ttgtttttac agtccagagg aaattgaagc   1080

taaagtggaa ccagctttgg tagtacccat taacaaggaa accagaatcc gggcaatgga   1140

taaggatgcc aagaaaagaa tccataattt ctctgtcatc aatcctgttc ctggacaagc   1200

tataactcag atttttgcag ttgacaatag agaagatctt cagaagtgga tggaagcctt   1260

ctggcagcat ttctttgatc ttagccaatg gaagcactgt tgtgaagaac ttatgaaaat   1320

tgagattatg tcaccacgga aaccaccttt gttcttgaca aaagaggcaa cctcagtcta   1380

ccatgatatg agcattgatt cacctatgaa acttgaaagt ttaacggata taatacaaaa   1440

aaaaattgaa gagacaaatg ggcagttcct tattggtcag catgaagaat ccttaccacc   1500

tccttgggcc acactctttg atggtaacca tcaaatggtc atccagaaaa aggtactgta   1560

tcctgcaagt gagccattac atgatgaaaa agggaaaaag agacaagctc cccttcctcc   1620

ttctgataaa cttccattca gcttaaaatc acagagtaac acagatcaat tggttaagga   1680

caactgggga aaaacaagtg tatctcagac atcgtctttg gataccaaac tatcaactct   1740

aatgcatcac ttacagaaac caatggctgc tcctcgaaaa cttctgcctg ccaggagaaa   1800

tagattaagt gatggtgagc acacagacac taaaaccaat tttgaagcca agccagtgcc   1860

agctccaagg cagaaatcca tcaaagacat tctggaccct agatcatggc tgcaggcaca   1920

agtatagaaa actcttaatg ataaaacatt taacaaaatc tataactgtg aagcttaatt   1980

cagaggcatt atagaataat gtgtaattat ataggtaaat atagtgattt ataccaataa   2040

ttaataagct attaggtata gaaaaacatt ttataatgaa gaagtggatt tctcttttac   2100

tcctgatttg cagaatgtaa gtgatttctc cagcagtgtg caagaggcag tttctagaca   2160

atatcctaat tgttggaagg gttaatttat tcctgaatta gtaccaggca gtgaataagc   2220

cctaggcaga ataaagcatt aaaatttctt ttggggagag actgtctagt aatttaaaat   2280

gtgttaaata tgaaccatat tctcattgtg agaattttaa tactaatgga atgtttcaaa   2340

ggttttattc aaaccacaaa ttatagaatc cacccaagaa aattttctta gcattctgga   2400

attctcatct aatggttcac tggctctcat ctattgttta actcactagt ttataggcct   2460

gaccttttaa attcctggga taaattttag aatattaaat tcttcatctt taaagggaat   2520

ttgtaatgtg ctattcaaac ttgtttcctt gatgagccct gaaatactgt tgacattaac   2580

tttcataaat gaagcataac acttactagt ttagagaaat ggtagatgaa atgctcttta   2640

cattcaattt tctgtgtgtg gtgctaattt ccattgtgac tttggaattt agggaagtga   2700

gtagctgatc aacaccttaa aattcattta atacttattt aaaaagaaga tgagagattc   2760

aaaaatatca gaaaagttgg ccatggtaaa taattttcag aattcttttt taaaatttta   2820

attagatttc cttttcctag taagagttga tgtctgctag tggtattttt cattaaatgt   2880

catattctta caacagtgac attggaatca tttccatagg aggtaatttc catagcaact   2940

aatcatagtg acccaaacag gattataaag tcaagtgagg aataaatagc agaaaaatac   3000

cttaaaggaa caaaaaatcc attttttata ataatgcttt ttgtaaacaa gagcagaaca   3060

gttttaaaaa tctaattaga atttccaaat aaaacagttt ccataaggtg tcagcaacag   3120

cactaaaaat ctcaaatcac actgaaccct aaatgtcatt gcaagaaata aaaatttaag   3180

aattaaattg ctgccctgtg tataatctct tgagatcttt ttaaagctag caagaactct   3240

atttggatca gaactacatt attacaaaac aaaatgaaca cttgaccaaa aaaccacatt   3300

aatttaaatg gagcctttca ttattttcag atagcggggt cttttccatt tatagagaat   3360

gatgtaactg ccaggacact tttgtgtttg cccaggactc ctagtaagaa ttgaatcttg   3420

agggagtaat gataacaaaa ggtttcttgt gactggtaac atcaggacag acagagtttt   3480

tggtgagaag aaagtactat atgcctgctt gatagcatgt agagatcatc acatgtatgg   3540

aaaccttaaa aagtaaactt attttttcta actagaaggc tctcataagt ttctgttatg   3600

attgccattt caataaatga cattaaaaat ctaaaggata ttattgtttg aatttttggg   3660

ttatttttta aaacttcatt gctgtttttg acagcatttg tgactgtcat tgccactaaa   3720

ttattgagct agaagatgct gcagggaaaa ttgttttgaa gctggcatct aagcattctt   3780

ttttttttcc tagttgatgc cttcctttat tacaaatcag tattaaaact tccagattat   3840

attcttgtca tttttcctca tgcagataac agcaggaagg acttaaggtg tataagaaaa   3900

agaaagtatt catacagaaa ttacctagca gttgtgccct cagagtagaa ctttgaaaca   3960

ggactgaagc cctttttacc tagaaccatt taaaagcctg agcaaggacc accaccccct   4020

ccccaccaaa ttattcggtc tctttctggg gggcccagct tactgtatgt tacaagtctt   4080

tgaaatgggt ctggtgtctt cagctcctga aatgctaatt taccccttac ctaaggagtg   4140

tagttataat acagagttgg tttccttcct tccttccttc cttccttcct tccttccttc   4200

cttccttcct tccttccttc cttccttcat tccctctgtc cgtctctcct tccctccttc   4260

cctccttcct tcctttttgt ctttgtttct ttctctggcc ccctgtcctc tctctctgtc   4320

tcatcccctt ttcccacttt ccttctgtct ctccttcctc ccttccttta cagtttaaaa   4380

aaaaaatcta aaaatagtta agcactgtgt caaagagtgt ttcaaaagaa ttgtttgttt   4440

tctcatttct taaaccagaa gtttatgaca aataaatatg ccatgtaata tgaaagctgc   4500

ttcagctttt tatgagcttt cacattcctt gtttgtcctt ttaatttgtt tcttgatata   4560

tgaagactat aaacttgaaa caaagagtta gctgtcagct cttgataata taattgggga   4620

aacagaatag atattttatg atatgataat tctgatgatc taaagataat gtcttagaca   4680

attaccttta catttcaagc tctgggatat aaattacgta gtcagcatta agatagtatt   4740

atttttaatt gctactaagt ggtaactttt gtattttaat atcttgcaag ggcaaagaag   4800

gcatttttaa aattctaaat gcacacctcc taaggtaaat agtctttcaa aaatatcagg   4860

cgtgccaact cttgctgagt tttgttaaat cctccttaac tgtctgcagt gccccctgac   4920

ttcttttaaa tggatgtgaa tatatgtgga aaactaaatc catttattat aaatgcctta   4980

tctttaccct ttgggatctt actaaatgca ttttacctgc tactatttat taaaaatgga   5040

agctgtcttg aattagagat acctcacgta aggtaggtta agcagtcaag tatttcttta   5100

ggcttatgtt cagcacctca gccccctact gagaagttaa ttaattcagt ccaaaatgaa   5160

attatagggc agtttggtgc aatttatgtt aaatgccatt tgaatgtaat cacctgtgtt   5220

accacgaatg aggcacaact atactacatg gacagagtac tgcattgcac catgagcaag   5280

aactgctctg caagaaaaat atctgtccct gtggtctgaa tttatcaaaa ctcattttct   5340

tgttaaagag tgaattattg aatagtaatt aaactttaac tgatgaccat ttatattcta   5400

gtagccatct tcactgttag tcttaaatta taatgtaaag ttgacatttt ccccttacat   5460

ttcaaaggca tcactatttt taaatgttta catatgttta catgtttgtg tgcaactgct   5520

tcattgctat taatagttaa atgaaatctg catattctgg atcatagatg ttcttagtta   5580

actctgggaa agatgttacc tttgggtttt taaaagacaa gtcatcattt gaaaatatat   5640

tagggtgtgt tgattttctg acatgcttgt gtaattggct ttgtttataa tttttatttt   5700

ttaatatggg tcagactttt ggattaaaaa gtattatatc atggacatac attttttaaa   5760

gtaccaaagg tatttggtaa gcgagcccaa gtcatgtaat tgaaacttct gtacattaaa   5820

agaactgatt catgaagacg ttttctaact ttttctcttt aagtgctcct ctagactaga   5880

ctgattgaag tagacagtgt ggtggaatca gtttaatcag aaaaagacat accaagtagc   5940

tggtgctaat tattataaga ctaacattct gataagccat ggtataatta acattattaa   6000

aatgtttaca tataatcctt cttaaagtat actcttttaa aaatccattg acataacctt   6060

acttttagtt tagtgatcca gaatttcccc agagcttaag ccactgcagt aaattaggta   6120

cgtaggatat tcagtcgcta ctagccacaa ggagtctcct tattttaatg tacctccctc   6180

agtactttat tcctgcagag cgcctcagag tgggggagag aaatgagcaa tcctggctca   6240

gttggattat ttcagcattt tatttctaaa tctgtagtgt gatcagaaat atttaaaatt   6300

aaaaaaatac tttacagaga gaggcctact aatcaatgtg cttagagaaa caaactacct   6360

ttacattcaa ttaacaacaa aaaaagttac agaaatttta acaaacattt ttctttatct   6420

gagtatggga gaaaatacta atgctgacac gtttaataat tagaaaagat cattccagat   6480

cttatggaaa attgtgtttt aaattccagc agtttgctct tgagacatgg taatctctta   6540

atgtaactac taaaggagag gtagattgaa aagatcttgt atatacataa ttatgtcaga   6600

tggttcaaga tatcaaaata aattgttttg ttgaaaatga aaaaaaaaaa aaaaaaaaa    6659


<210>  389
<211>  609
<212>  PRT
<213>  Homo sapiens

<400>  389


Met Glu Gly Pro Ser Leu Arg Gly Pro Ala Leu Arg Leu Ala Gly Leu 
1               5                   10                  15      


Pro Thr Gln Gln Asp Cys Asn Ile Gln Glu Lys Ile Asp Leu Glu Ile 
            20                  25                  30          


Arg Met Arg Glu Gly Ile Trp Lys Leu Leu Ser Leu Ser Thr Gln Lys 
        35                  40                  45              


Asp Gln Val Leu His Ala Val Lys Asn Leu Met Val Cys Asn Ala Arg 
    50                  55                  60                  


Leu Met Ala Tyr Thr Ser Glu Leu Gln Lys Leu Glu Glu Gln Ile Ala 
65                  70                  75                  80  


Asn Gln Thr Gly Arg Cys Asp Val Lys Phe Glu Ser Lys Glu Arg Thr 
                85                  90                  95      


Ala Cys Lys Gly Lys Ile Ala Ile Ser Asp Ile Arg Ile Pro Leu Met 
            100                 105                 110         


Trp Lys Asp Ser Asp His Phe Ser Asn Lys Glu Arg Ser Arg Arg Tyr 
        115                 120                 125             


Ala Ile Phe Cys Leu Phe Lys Met Gly Ala Asn Val Phe Asp Thr Asp 
    130                 135                 140                 


Val Val Asn Val Asp Lys Thr Ile Thr Asp Ile Cys Phe Glu Asn Val 
145                 150                 155                 160 


Thr Ile Phe Asn Glu Ala Gly Pro Asp Phe Gln Ile Lys Val Glu Val 
                165                 170                 175     


Tyr Ser Cys Cys Thr Glu Glu Ser Ser Ile Thr Asn Thr Pro Lys Lys 
            180                 185                 190         


Leu Ala Lys Lys Leu Lys Thr Ser Ile Ser Lys Ala Thr Gly Lys Lys 
        195                 200                 205             


Ile Ser Ser Val Leu Gln Glu Glu Asp Asp Glu Met Cys Leu Leu Leu 
    210                 215                 220                 


Ser Ser Ala Val Phe Gly Val Lys Tyr Asn Leu Leu Ala His Thr Thr 
225                 230                 235                 240 


Leu Thr Leu Glu Ser Ala Glu Asp Ser Phe Lys Thr His Asn Leu Ser 
                245                 250                 255     


Ile Asn Gly Asn Glu Glu Ser Ser Phe Trp Leu Pro Leu Tyr Gly Asn 
            260                 265                 270         


Met Cys Cys Arg Leu Val Ala Gln Pro Ala Cys Met Ala Glu Asp Ala 
        275                 280                 285             


Phe Ala Gly Phe Leu Asn Gln Gln Gln Met Val Glu Gly Leu Ile Ser 
    290                 295                 300                 


Trp Arg Arg Leu Tyr Cys Val Leu Arg Gly Gly Lys Leu Tyr Cys Phe 
305                 310                 315                 320 


Tyr Ser Pro Glu Glu Ile Glu Ala Lys Val Glu Pro Ala Leu Val Val 
                325                 330                 335     


Pro Ile Asn Lys Glu Thr Arg Ile Arg Ala Met Asp Lys Asp Ala Lys 
            340                 345                 350         


Lys Arg Ile His Asn Phe Ser Val Ile Asn Pro Val Pro Gly Gln Ala 
        355                 360                 365             


Ile Thr Gln Ile Phe Ala Val Asp Asn Arg Glu Asp Leu Gln Lys Trp 
    370                 375                 380                 


Met Glu Ala Phe Trp Gln His Phe Phe Asp Leu Ser Gln Trp Lys His 
385                 390                 395                 400 


Cys Cys Glu Glu Leu Met Lys Ile Glu Ile Met Ser Pro Arg Lys Pro 
                405                 410                 415     


Pro Leu Phe Leu Thr Lys Glu Ala Thr Ser Val Tyr His Asp Met Ser 
            420                 425                 430         


Ile Asp Ser Pro Met Lys Leu Glu Ser Leu Thr Asp Ile Ile Gln Lys 
        435                 440                 445             


Lys Ile Glu Glu Thr Asn Gly Gln Phe Leu Ile Gly Gln His Glu Glu 
    450                 455                 460                 


Ser Leu Pro Pro Pro Trp Ala Thr Leu Phe Asp Gly Asn His Gln Met 
465                 470                 475                 480 


Val Ile Gln Lys Lys Val Leu Tyr Pro Ala Ser Glu Pro Leu His Asp 
                485                 490                 495     


Glu Lys Gly Lys Lys Arg Gln Ala Pro Leu Pro Pro Ser Asp Lys Leu 
            500                 505                 510         


Pro Phe Ser Leu Lys Ser Gln Ser Asn Thr Asp Gln Leu Val Lys Asp 
        515                 520                 525             


Asn Trp Gly Lys Thr Ser Val Ser Gln Thr Ser Ser Leu Asp Thr Lys 
    530                 535                 540                 


Leu Ser Thr Leu Met His His Leu Gln Lys Pro Met Ala Ala Pro Arg 
545                 550                 555                 560 


Lys Leu Leu Pro Ala Arg Arg Asn Arg Leu Ser Asp Gly Glu His Thr 
                565                 570                 575     


Asp Thr Lys Thr Asn Phe Glu Ala Lys Pro Val Pro Ala Pro Arg Gln 
            580                 585                 590         


Lys Ser Ile Lys Asp Ile Leu Asp Pro Arg Ser Trp Leu Gln Ala Gln 
        595                 600                 605             


Val 
    

<210>  390
<211>  2490
<212>  DNA
<213>  Homo sapiens

<400>  390
actgtccgcc gccgtgtccg cggctgcgcc agacagtgta gaacctgcgg cctcgatgtc     60

cttctcccgt gccctattgt gggctcggct cccggcgggg cgccaggctg gccaccgggc    120

agccatctgc tctgcccttc gtccccactt tgggcccttt cccggggttc tggggcaagt    180

ttctgtcctt gccaccgcct cctcctctgc ctccggtggc tccaaaatac caaacacgtc    240

cttgttcgtg cccctgactg tgaaacctca gggccccagc gccgacggcg acgtcggggc    300

cgagctaacc cggcctctgg acaagaatga agtaaagaag gtcttagaca aattttacaa    360

gaggaaagaa attcagaaac tgggtgctga ttatggactt gatgctcgtc tcttccacca    420

agctttcata agctttagaa attatattat gcagtctcat tccctggatg tggacattca    480

cattgttttg aatgatattt gcttcggtgc agctcatgcg gatgatttat tcccattttt    540

cttgagacat gccaaacaaa tatttcctgt gttggactgt aaggatgatc tacgtaaaat    600

cagtgactta agaataccac ctaactggta cccagatgct agagccatgc agcggaagat    660

aatatttcat tcaggcccca caaacagtgg aaagacttat cacgcaatcc agaaatactt    720

ctcagcaaag tctggagtgt attgtggccc tctaaaatta ctggcacatg agatcttcga    780

aaagagtaat gctgctggtg tgccatgtga cttggtgaca ggtgaagagc gtgtgacagt    840

tcagccaaat gggaaacagg cttcacatgt ttcttgtaca gttgagatgt gcagtgttac    900

aactccttat gaagtggctg taattgatga aattcaaatg attagagatc cagccagagg    960

atgggcctgg accagagcac ttctaggact gtgtgctgaa gaggttcatt tgtgtggaga   1020

acctgctgct attgacctgg tgatggagct tatgtacaca acgggggagg aagtggaggt   1080

tcgagactat aagaggctta cccccatttc tgtgctggac catgcactag aatctttaga   1140

taaccttcgg cctggggact gcattgtctg ttttagcaag aatgatattt attctgtgag   1200

tcggcagatt gaaattcggg gattagaatc agctgttata tatggcagtc tcccacctgg   1260

gaccaaactt gctcaagcaa aaaagtttaa tgatcccaat gacccatgca aaatcttggt   1320

tgctacagat gcaattggca tgggacttaa tttgagcata aggagaatta ttttttactc   1380

ccttataaag cccagtatca atgaaaaggg agagagagaa ctagaaccaa tcacaacctc   1440

tcaagccctg cagattgctg gcagagctgg cagattcagc tcacggttta aagaaggaga   1500

ggttacaaca atgaatcatg aagatctcag tttattaaag gaaattttga agaggcctgt   1560

ggatcctata agggcagctg gtcttcatcc aactgctgag cagattgaaa tgtttgccta   1620

ccatctccct gatgcaacac tgtccaatct cattgatatt tttgtagact tttcacaagt   1680

tgatgggcag tattttgtct gcaatatgga tgattttaaa ttttctgcag agttgatcca   1740

gcatattcca ctaagtctgc gagtgaggta tgttttctgc acagctccta tcaacaagaa   1800

gcagcctttt gtgtgttctt cactgttaca gtttgccagg cagtatagca ggaatgagcc   1860

cctgaccttt gcatggttac gccgatacat caaatggcct ttacttccac ctaagaatat   1920

taaagacctc atggatcttg aagctgtcca cgatgtcttg gatctttact tgtggctaag   1980

ctaccgattt atggatatgt ttccagatgc cagccttatt cgagatctcc agaaagaact   2040

agatggtatt atccaagatg gtgtgcacaa tatcactaaa ttgattaaaa tgtctgagac   2100

gcataagctg ttgaatttgg agggctttcc atcagggagc cagtcacgat tgtcaggaac   2160

cttaaagagc caagctagaa ggacacgcgg caccaaagct ctagggagta aagctactga   2220

gccacccagc cccgatgcag gagagctgtc ccttgcttcc agattggtgc agcaaggact   2280

cctcactcca gacatgctga aacagctaga aaaagagtgg atgacacaac aaactgaaca   2340

caacaaagaa aaaacagagt ctgggactca tccaaaaggg acgagaagaa agaagaagga   2400

acctgattcg gactagtttt ctgttcctgt tttttttttt ttatttaatt ttgcaaataa   2460

aaatttattt tgaagaaaaa aaaaaaaaaa                                    2490


<210>  391
<211>  786
<212>  PRT
<213>  Homo sapiens

<400>  391


Met Ser Phe Ser Arg Ala Leu Leu Trp Ala Arg Leu Pro Ala Gly Arg 
1               5                   10                  15      


Gln Ala Gly His Arg Ala Ala Ile Cys Ser Ala Leu Arg Pro His Phe 
            20                  25                  30          


Gly Pro Phe Pro Gly Val Leu Gly Gln Val Ser Val Leu Ala Thr Ala 
        35                  40                  45              


Ser Ser Ser Ala Ser Gly Gly Ser Lys Ile Pro Asn Thr Ser Leu Phe 
    50                  55                  60                  


Val Pro Leu Thr Val Lys Pro Gln Gly Pro Ser Ala Asp Gly Asp Val 
65                  70                  75                  80  


Gly Ala Glu Leu Thr Arg Pro Leu Asp Lys Asn Glu Val Lys Lys Val 
                85                  90                  95      


Leu Asp Lys Phe Tyr Lys Arg Lys Glu Ile Gln Lys Leu Gly Ala Asp 
            100                 105                 110         


Tyr Gly Leu Asp Ala Arg Leu Phe His Gln Ala Phe Ile Ser Phe Arg 
        115                 120                 125             


Asn Tyr Ile Met Gln Ser His Ser Leu Asp Val Asp Ile His Ile Val 
    130                 135                 140                 


Leu Asn Asp Ile Cys Phe Gly Ala Ala His Ala Asp Asp Leu Phe Pro 
145                 150                 155                 160 


Phe Phe Leu Arg His Ala Lys Gln Ile Phe Pro Val Leu Asp Cys Lys 
                165                 170                 175     


Asp Asp Leu Arg Lys Ile Ser Asp Leu Arg Ile Pro Pro Asn Trp Tyr 
            180                 185                 190         


Pro Asp Ala Arg Ala Met Gln Arg Lys Ile Ile Phe His Ser Gly Pro 
        195                 200                 205             


Thr Asn Ser Gly Lys Thr Tyr His Ala Ile Gln Lys Tyr Phe Ser Ala 
    210                 215                 220                 


Lys Ser Gly Val Tyr Cys Gly Pro Leu Lys Leu Leu Ala His Glu Ile 
225                 230                 235                 240 


Phe Glu Lys Ser Asn Ala Ala Gly Val Pro Cys Asp Leu Val Thr Gly 
                245                 250                 255     


Glu Glu Arg Val Thr Val Gln Pro Asn Gly Lys Gln Ala Ser His Val 
            260                 265                 270         


Ser Cys Thr Val Glu Met Cys Ser Val Thr Thr Pro Tyr Glu Val Ala 
        275                 280                 285             


Val Ile Asp Glu Ile Gln Met Ile Arg Asp Pro Ala Arg Gly Trp Ala 
    290                 295                 300                 


Trp Thr Arg Ala Leu Leu Gly Leu Cys Ala Glu Glu Val His Leu Cys 
305                 310                 315                 320 


Gly Glu Pro Ala Ala Ile Asp Leu Val Met Glu Leu Met Tyr Thr Thr 
                325                 330                 335     


Gly Glu Glu Val Glu Val Arg Asp Tyr Lys Arg Leu Thr Pro Ile Ser 
            340                 345                 350         


Val Leu Asp His Ala Leu Glu Ser Leu Asp Asn Leu Arg Pro Gly Asp 
        355                 360                 365             


Cys Ile Val Cys Phe Ser Lys Asn Asp Ile Tyr Ser Val Ser Arg Gln 
    370                 375                 380                 


Ile Glu Ile Arg Gly Leu Glu Ser Ala Val Ile Tyr Gly Ser Leu Pro 
385                 390                 395                 400 


Pro Gly Thr Lys Leu Ala Gln Ala Lys Lys Phe Asn Asp Pro Asn Asp 
                405                 410                 415     


Pro Cys Lys Ile Leu Val Ala Thr Asp Ala Ile Gly Met Gly Leu Asn 
            420                 425                 430         


Leu Ser Ile Arg Arg Ile Ile Phe Tyr Ser Leu Ile Lys Pro Ser Ile 
        435                 440                 445             


Asn Glu Lys Gly Glu Arg Glu Leu Glu Pro Ile Thr Thr Ser Gln Ala 
    450                 455                 460                 


Leu Gln Ile Ala Gly Arg Ala Gly Arg Phe Ser Ser Arg Phe Lys Glu 
465                 470                 475                 480 


Gly Glu Val Thr Thr Met Asn His Glu Asp Leu Ser Leu Leu Lys Glu 
                485                 490                 495     


Ile Leu Lys Arg Pro Val Asp Pro Ile Arg Ala Ala Gly Leu His Pro 
            500                 505                 510         


Thr Ala Glu Gln Ile Glu Met Phe Ala Tyr His Leu Pro Asp Ala Thr 
        515                 520                 525             


Leu Ser Asn Leu Ile Asp Ile Phe Val Asp Phe Ser Gln Val Asp Gly 
    530                 535                 540                 


Gln Tyr Phe Val Cys Asn Met Asp Asp Phe Lys Phe Ser Ala Glu Leu 
545                 550                 555                 560 


Ile Gln His Ile Pro Leu Ser Leu Arg Val Arg Tyr Val Phe Cys Thr 
                565                 570                 575     


Ala Pro Ile Asn Lys Lys Gln Pro Phe Val Cys Ser Ser Leu Leu Gln 
            580                 585                 590         


Phe Ala Arg Gln Tyr Ser Arg Asn Glu Pro Leu Thr Phe Ala Trp Leu 
        595                 600                 605             


Arg Arg Tyr Ile Lys Trp Pro Leu Leu Pro Pro Lys Asn Ile Lys Asp 
    610                 615                 620                 


Leu Met Asp Leu Glu Ala Val His Asp Val Leu Asp Leu Tyr Leu Trp 
625                 630                 635                 640 


Leu Ser Tyr Arg Phe Met Asp Met Phe Pro Asp Ala Ser Leu Ile Arg 
                645                 650                 655     


Asp Leu Gln Lys Glu Leu Asp Gly Ile Ile Gln Asp Gly Val His Asn 
            660                 665                 670         


Ile Thr Lys Leu Ile Lys Met Ser Glu Thr His Lys Leu Leu Asn Leu 
        675                 680                 685             


Glu Gly Phe Pro Ser Gly Ser Gln Ser Arg Leu Ser Gly Thr Leu Lys 
    690                 695                 700                 


Ser Gln Ala Arg Arg Thr Arg Gly Thr Lys Ala Leu Gly Ser Lys Ala 
705                 710                 715                 720 


Thr Glu Pro Pro Ser Pro Asp Ala Gly Glu Leu Ser Leu Ala Ser Arg 
                725                 730                 735     


Leu Val Gln Gln Gly Leu Leu Thr Pro Asp Met Leu Lys Gln Leu Glu 
            740                 745                 750         


Lys Glu Trp Met Thr Gln Gln Thr Glu His Asn Lys Glu Lys Thr Glu 
        755                 760                 765             


Ser Gly Thr His Pro Lys Gly Thr Arg Arg Lys Lys Lys Glu Pro Asp 
    770                 775                 780                 


Ser Asp 
785     

<210>  392
<211>  3719
<212>  DNA
<213>  Homo sapiens

<400>  392
atttagtccg caacacctcg ctccccagga ggtctgccag cctggactgg aagcgtgcaa     60

cactccagag tcgtaggagt gaacactgca caggaatctc tgcccatctc aggagaaacc    120

aaacttgggg aaaatgtttg cggtccactt gatggcattt tacttcagca agctgaagga    180

ggaccagatc aagaaggtgg acaggttcct gtatcacatg cggctctccg atgacaccct    240

tttggacatc atgaggcggt tccgggctga gatggagaag ggcctggcaa aggacaccaa    300

ccccacggct gcagtgaaga tgttgcccac cttcgtcagg gccattcccg atggttccga    360

aaatggggag ttcctttccc tggatctcgg agggtccaag ttccgagtgc tgaaggtgca    420

agtcgctgaa gaggggaagc gacacgtgca gatggagagt cagttctacc caacgcccaa    480

tgaaatcatc cgcgggaacg gcacagagct gtttgaatat gtagctgact gtctggcaga    540

tttcatgaag accaaagatt taaagcataa gaaattgccc cttggcctaa ctttttcttt    600

cccctgtcga cagactaaac tggaagaggg tgtcctactt tcgtggacaa aaaagtttaa    660

ggcacgagga gttcaggaca cggatgtggt gagccgtctg accaaagcca tgagaagaca    720

caaggacatg gacgtggaca tcctggccct ggtcaatgac accgtgggga ccatgatgac    780

ctgtgcctat gacgacccct actgcgaagt tggtgtcatc atcggaactg gcaccaatgc    840

gtgttacatg gaggacatga gcaacattga cctggtggag ggcgacgagg gcaggatgtg    900

catcaacaca gagtgggggg ccttcgggga cgacggggcc ctggaggaca ttcgcactga    960

gttcgacagg gagctggacc tcggctctct caacccagga aagcaactgt tcgagaagat   1020

gatcagtggc ctgtacctgg gggagcttgt caggcttatc ttgctgaaga tggccaaggc   1080

tggcctcctg tttggtggtg agaaatcttc tgctctccac actaagggca agatcgaaac   1140

acggcacgtg gctgccatgg agaagtataa agaaggcctt gctaatacaa gagagatcct   1200

ggtggacctg ggtctggaac cgtctgaggc tgactgcatt gccgtccagc atgtctgtac   1260

catcgtctcc ttccgctcgg ccaatctctg tgcagcagct ctggcggcca tcctgacacg   1320

cctccgggag aacaagaagg tggaacggct ccggaccaca gtgggcatgg acggcaccct   1380

ctacaagata caccctcagt acccaaaacg cctgcacaag gtggtgagga aactggtccc   1440

aagctgtgat gtccgcttcc tcctgtcaga gagtggcagc accaaggggg ccgccatggt   1500

gaccgcggtg gcctcccgcg tgcaggccca gcggaagcag atcgacaggg tgctggcttt   1560

gttccagctg acccgagagc agctcgtgga cgtgcaggcc aagatgcggg ctgagctgga   1620

gtatgggctg aagaagaaga gccacgggct ggccacggtc aggatgctgc ccacctacgt   1680

ctgcgggctg ccggacggca cagagaaagg aaagtttctc gccctggatc ttgggggaac   1740

caacttccgg gtcctcctgg tgaagatcag aagtggacgg aggtcagtgc gaatgtacaa   1800

caagatcttc gccatccccc tggagatcat gcagggcact ggtgaggagc tctttgatca   1860

cattgtgcag tgcatcgccg acttcctgga ctacatgggc ctcaagggag cctccctacc   1920

tttgggcttc acattctcat ttccctgcag gcagatgagc attgacaagg gaacactcat   1980

agggtggacc aaaggtttca aggccactga ctgtgaaggg gaggacgtgg tggacatgct   2040

cagggaagcc atcaagagga gaaacgagtt tgacctggac attgttgcag tcgtgaatga   2100

tacagtgggg accatgatga cctgtggcta tgaagatcct aattgtgaga ttggcctgat   2160

tgcaggaaca ggcagcaaca tgtgctacat ggaggacatg aggaacatcg agatggtgga   2220

ggggggtgaa gggaagatgt gcatcaatac agagtgggga ggatttggag acaatggctg   2280

catagatgac atccggaccc gatacgacac ggaggtggat gaggggtcct tgaatcctgg   2340

caagcagaga tacgagaaaa tgaccagtgg gatgtacttg ggggagattg tgcggcagat   2400

cctgatcgac ctgaccaagc agggtctcct cttccgaggg cagatttcag agcgtctccg   2460

gaccaggggc atcttcgaaa ccaagttcct gtcccagatc gaaagcgatc ggctggccct   2520

tctccaggtc aggaggattc tgcagcagct gggcctggac agcacgtgtg aggacagcat   2580

cgtggtgaag gaggtgtgcg gagccgtgtc ccggcgggcg gcccagctct gcggtgctgg   2640

cctggccgct atagtggaaa aaaggagaga agaccagggg ctagagcacc tgaggatcac   2700

tgtgggtgtg gacggcaccc tgtacaagct gcaccctcac ttttctagaa tattgcagga   2760

aactgtgaag gaactagccc ctcgatgtga tgtgacattc atgctgtcag aagatggcag   2820

tggaaaaggg gcagcactga tcactgctgt ggccaagagg ttacagcagg cacagaagga   2880

gaactaggaa cccctgggat tggacctgat gcatcttgga tactgaacag cttttcctct   2940

ggcagatcag ttggtcagag accaatgggc accctcctgg ctgacctcac cttctggatg   3000

gccgaaagag aaccccaggt tctcgggtac tcttagtatc ttgtactgga tttgcagtga   3060

cattacatga catctctatt tggtatattt gggccaaaat gggccaactt atgaaatcaa   3120

agtgtctgtc ctgagagatc ccctttcaac acattgttca ggtgaggctt gagctgtcaa   3180

ttctctatgg ctttcagtct tgtggctgcg ggacttggaa atatatagaa tctgcccatg   3240

tggctggcag gctgtttccc cattgggatg cttaagccat ctcttatagg ggattggacc   3300

ctgtacttgt ggatgaacat tggagagcaa gaggaactca cgttatgaac tagggggatc   3360

tcatctaact tgtccttaac ttgccatgtt gacttcaaac ctgttaagag aacaaagact   3420

ttgaagtatc cagccccagg gtgcagagag gttgattgcc agggagcact gcaggaatca   3480

ttgcatgctt aaagcgagtt atgtcagcac cctgtaggat tttgttcctt attaagtgtg   3540

tgccatgtgg tggggtgctg tctggggcat ctgtttttca ttttgcctgt ggtttgtgtt   3600

gcaggtgttg atagttgttt taaggattgt taggtatagg aaatccagta aattaataaa   3660

aaaattttga ttttccaata aactttgcaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa    3719


<210>  393
<211>  917
<212>  PRT
<213>  Homo sapiens

<400>  393


Met Phe Ala Val His Leu Met Ala Phe Tyr Phe Ser Lys Leu Lys Glu 
1               5                   10                  15      


Asp Gln Ile Lys Lys Val Asp Arg Phe Leu Tyr His Met Arg Leu Ser 
            20                  25                  30          


Asp Asp Thr Leu Leu Asp Ile Met Arg Arg Phe Arg Ala Glu Met Glu 
        35                  40                  45              


Lys Gly Leu Ala Lys Asp Thr Asn Pro Thr Ala Ala Val Lys Met Leu 
    50                  55                  60                  


Pro Thr Phe Val Arg Ala Ile Pro Asp Gly Ser Glu Asn Gly Glu Phe 
65                  70                  75                  80  


Leu Ser Leu Asp Leu Gly Gly Ser Lys Phe Arg Val Leu Lys Val Gln 
                85                  90                  95      


Val Ala Glu Glu Gly Lys Arg His Val Gln Met Glu Ser Gln Phe Tyr 
            100                 105                 110         


Pro Thr Pro Asn Glu Ile Ile Arg Gly Asn Gly Thr Glu Leu Phe Glu 
        115                 120                 125             


Tyr Val Ala Asp Cys Leu Ala Asp Phe Met Lys Thr Lys Asp Leu Lys 
    130                 135                 140                 


His Lys Lys Leu Pro Leu Gly Leu Thr Phe Ser Phe Pro Cys Arg Gln 
145                 150                 155                 160 


Thr Lys Leu Glu Glu Gly Val Leu Leu Ser Trp Thr Lys Lys Phe Lys 
                165                 170                 175     


Ala Arg Gly Val Gln Asp Thr Asp Val Val Ser Arg Leu Thr Lys Ala 
            180                 185                 190         


Met Arg Arg His Lys Asp Met Asp Val Asp Ile Leu Ala Leu Val Asn 
        195                 200                 205             


Asp Thr Val Gly Thr Met Met Thr Cys Ala Tyr Asp Asp Pro Tyr Cys 
    210                 215                 220                 


Glu Val Gly Val Ile Ile Gly Thr Gly Thr Asn Ala Cys Tyr Met Glu 
225                 230                 235                 240 


Asp Met Ser Asn Ile Asp Leu Val Glu Gly Asp Glu Gly Arg Met Cys 
                245                 250                 255     


Ile Asn Thr Glu Trp Gly Ala Phe Gly Asp Asp Gly Ala Leu Glu Asp 
            260                 265                 270         


Ile Arg Thr Glu Phe Asp Arg Glu Leu Asp Leu Gly Ser Leu Asn Pro 
        275                 280                 285             


Gly Lys Gln Leu Phe Glu Lys Met Ile Ser Gly Leu Tyr Leu Gly Glu 
    290                 295                 300                 


Leu Val Arg Leu Ile Leu Leu Lys Met Ala Lys Ala Gly Leu Leu Phe 
305                 310                 315                 320 


Gly Gly Glu Lys Ser Ser Ala Leu His Thr Lys Gly Lys Ile Glu Thr 
                325                 330                 335     


Arg His Val Ala Ala Met Glu Lys Tyr Lys Glu Gly Leu Ala Asn Thr 
            340                 345                 350         


Arg Glu Ile Leu Val Asp Leu Gly Leu Glu Pro Ser Glu Ala Asp Cys 
        355                 360                 365             


Ile Ala Val Gln His Val Cys Thr Ile Val Ser Phe Arg Ser Ala Asn 
    370                 375                 380                 


Leu Cys Ala Ala Ala Leu Ala Ala Ile Leu Thr Arg Leu Arg Glu Asn 
385                 390                 395                 400 


Lys Lys Val Glu Arg Leu Arg Thr Thr Val Gly Met Asp Gly Thr Leu 
                405                 410                 415     


Tyr Lys Ile His Pro Gln Tyr Pro Lys Arg Leu His Lys Val Val Arg 
            420                 425                 430         


Lys Leu Val Pro Ser Cys Asp Val Arg Phe Leu Leu Ser Glu Ser Gly 
        435                 440                 445             


Ser Thr Lys Gly Ala Ala Met Val Thr Ala Val Ala Ser Arg Val Gln 
    450                 455                 460                 


Ala Gln Arg Lys Gln Ile Asp Arg Val Leu Ala Leu Phe Gln Leu Thr 
465                 470                 475                 480 


Arg Glu Gln Leu Val Asp Val Gln Ala Lys Met Arg Ala Glu Leu Glu 
                485                 490                 495     


Tyr Gly Leu Lys Lys Lys Ser His Gly Leu Ala Thr Val Arg Met Leu 
            500                 505                 510         


Pro Thr Tyr Val Cys Gly Leu Pro Asp Gly Thr Glu Lys Gly Lys Phe 
        515                 520                 525             


Leu Ala Leu Asp Leu Gly Gly Thr Asn Phe Arg Val Leu Leu Val Lys 
    530                 535                 540                 


Ile Arg Ser Gly Arg Arg Ser Val Arg Met Tyr Asn Lys Ile Phe Ala 
545                 550                 555                 560 


Ile Pro Leu Glu Ile Met Gln Gly Thr Gly Glu Glu Leu Phe Asp His 
                565                 570                 575     


Ile Val Gln Cys Ile Ala Asp Phe Leu Asp Tyr Met Gly Leu Lys Gly 
            580                 585                 590         


Ala Ser Leu Pro Leu Gly Phe Thr Phe Ser Phe Pro Cys Arg Gln Met 
        595                 600                 605             


Ser Ile Asp Lys Gly Thr Leu Ile Gly Trp Thr Lys Gly Phe Lys Ala 
    610                 615                 620                 


Thr Asp Cys Glu Gly Glu Asp Val Val Asp Met Leu Arg Glu Ala Ile 
625                 630                 635                 640 


Lys Arg Arg Asn Glu Phe Asp Leu Asp Ile Val Ala Val Val Asn Asp 
                645                 650                 655     


Thr Val Gly Thr Met Met Thr Cys Gly Tyr Glu Asp Pro Asn Cys Glu 
            660                 665                 670         


Ile Gly Leu Ile Ala Gly Thr Gly Ser Asn Met Cys Tyr Met Glu Asp 
        675                 680                 685             


Met Arg Asn Ile Glu Met Val Glu Gly Gly Glu Gly Lys Met Cys Ile 
    690                 695                 700                 


Asn Thr Glu Trp Gly Gly Phe Gly Asp Asn Gly Cys Ile Asp Asp Ile 
705                 710                 715                 720 


Arg Thr Arg Tyr Asp Thr Glu Val Asp Glu Gly Ser Leu Asn Pro Gly 
                725                 730                 735     


Lys Gln Arg Tyr Glu Lys Met Thr Ser Gly Met Tyr Leu Gly Glu Ile 
            740                 745                 750         


Val Arg Gln Ile Leu Ile Asp Leu Thr Lys Gln Gly Leu Leu Phe Arg 
        755                 760                 765             


Gly Gln Ile Ser Glu Arg Leu Arg Thr Arg Gly Ile Phe Glu Thr Lys 
    770                 775                 780                 


Phe Leu Ser Gln Ile Glu Ser Asp Arg Leu Ala Leu Leu Gln Val Arg 
785                 790                 795                 800 


Arg Ile Leu Gln Gln Leu Gly Leu Asp Ser Thr Cys Glu Asp Ser Ile 
                805                 810                 815     


Val Val Lys Glu Val Cys Gly Ala Val Ser Arg Arg Ala Ala Gln Leu 
            820                 825                 830         


Cys Gly Ala Gly Leu Ala Ala Ile Val Glu Lys Arg Arg Glu Asp Gln 
        835                 840                 845             


Gly Leu Glu His Leu Arg Ile Thr Val Gly Val Asp Gly Thr Leu Tyr 
    850                 855                 860                 


Lys Leu His Pro His Phe Ser Arg Ile Leu Gln Glu Thr Val Lys Glu 
865                 870                 875                 880 


Leu Ala Pro Arg Cys Asp Val Thr Phe Met Leu Ser Glu Asp Gly Ser 
                885                 890                 895     


Gly Lys Gly Ala Ala Leu Ile Thr Ala Val Ala Lys Arg Leu Gln Gln 
            900                 905                 910         


Ala Gln Lys Glu Asn 
        915         

<210>  394
<211>  2564
<212>  DNA
<213>  Homo sapiens

<400>  394
cttgctcgcg gagagaggag ctaggagcct cggccaatgg gagccggcgt tgttggaggc     60

cacggcggcg cagccccaaa gcgagcgaag ctagggtcgc cgccactgcc gcaggaggcg    120

tgaggggata aaaacattca gatggcagat cacagttttt cagatggggt tccttcagat    180

tccgtggaag ctgctaaaaa tgcaagtaac acagaaaagc tcacagatca ggtgatgcag    240

aatcctcgag ttctggcagc tttacaggag cgacttgaca atgtccctca caccccttcc    300

agctacatcg aaactttacc taaagcagta aaaagaagaa ttaatgcatt gaaacaactt    360

caggtgagat gtgctcacat agaagccaag ttctatgaag aggtacatga cttggaaaga    420

aagtatgcag cgctatacca gcctctcttt gacaagagaa gagaatttat caccggcgat    480

gttgaaccaa cagatgcgga atcggaatgg cacagtgaaa atgaagagga agagaaattg    540

gctggagaca tgaaaagtaa agtagtcgtc acagaaaaag cagcggcaac ggctgaagag    600

ccagatccca aaggaattcc agagttctgg tttaccatct tcagaaatgt ggacatgctg    660

agtgaattag tccaggaata tgatgaacca atcttgaaac acctgcagga tattaaagtg    720

aaattttctg accctggaca gcctatgtct tttgtgttag agttccactt tgaacccaac    780

gactacttta ccaactcagt cctgacaaaa acctacaaga tgaaatcaga accagataag    840

gctgatccct tttcctttga aggtcctgag attgtggact gtgacgggtg tactattgac    900

tggaagaaag gaaagaatgt tactgtcaaa accatcaaga aaaagcagaa gcataagggt    960

cgaggcactg ttagaacaat tacgaaacaa gtacccaatg agtccttttt caacttcttc   1020

aatccattga aagcatccgg ggatggagaa tcactggatg aagattctga attcacatta   1080

gcctctgatt ttgaaattgg acactttttc cgtgagcgga tagtcccgcg ggctgtgctg   1140

tacttcactg gggaggccat agaagatgat gacaattttg aagaaggtga agaaggagaa   1200

gaggaggaat tagaaggtga cgaggaggga gaagacgagg atgatgcgga aattaacccc   1260

aaggtgtaat ttttgtctgt taatcattca tacgtttcta gaaggaaccc agccagccgg   1320

cggaatgcaa gcagcagtag gaagcggagg cgggtgcctg gcagaccggc tgtcgggact   1380

ccaggcctgt gggcggggcc tcggtccttg ccgcagcaca atcccgtgga cagagcttac   1440

tccatctaac tcgttttcaa gtgcatgatt ttcactttca cttttccttt ttccttatta   1500

ttttgcttaa cttgtacagt ggcaactgaa atgcatttca gaaataggag gtttcgtcca   1560

gcaccctctg cagccttggt gcctgtagct ctggacttcc ctgggccttt ccctgtggga   1620

gggccctgta gaccacatca gggtggggtg ggggtcactt ggcaaaaagg gccgaggtct   1680

ggtgatgtgg ttcccaggat ctggaacctc tcccacccct cctgcagttg gactgaattc   1740

ttccctttca tccgaagaaa cccacttgct gtttccagcc gctgaatctg ctgagtgtgc   1800

agcctgcatc acctgctgta tgccgatcat ctcagaaagg gctgtgtaga gtagggccct   1860

gttctcctta ggatgttgct tcttgatttt tttttttttt taggggtggg tcagggttgt   1920

gacacaccag cccaggtgag agctgctgcg ggtcacctca tatttattta tcccttcttg   1980

cctgtgagga ctgcggcttt tcgctgtggc tcgtccttaa cgtttctgaa ccaccttggt   2040

gccctgagca ggaagatgtg ccacttccta gcaggcgcaa ggcctgtgcg gaagaaacgc   2100

cgctccctgc caccagggct gaagatgcga gcccgtcctc atgacgcagg cgccaccctg   2160

ctgccggagc cgggcttcgg cagtcttctc cactgaggga ctgggctggg aagtcctgcg   2220

tttcagtgga gcgtatgagc gtcaagtcct gctttctcag tagccccatt gcggggcccc   2280

accattcatc ctgtctgaag gtcctgggtt tggtgtgacc gcttggcggc tggtgggtgg   2340

ggttttcaag tgggtgacgg cgctctccgg cagccgggga tggccgtgtc cgcactgacc   2400

aggcctgtgg agagtgctcg gcctaacctt agaacacatt tgtaactgaa tacagtgttt   2460

tcaatttgta cagaatagtt agaatattct attaaagtgg tgaaacattg agtcagcaaa   2520

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa                    2564


<210>  395
<211>  375
<212>  PRT
<213>  Homo sapiens

<400>  395


Met Ala Asp His Ser Phe Ser Asp Gly Val Pro Ser Asp Ser Val Glu 
1               5                   10                  15      


Ala Ala Lys Asn Ala Ser Asn Thr Glu Lys Leu Thr Asp Gln Val Met 
            20                  25                  30          


Gln Asn Pro Arg Val Leu Ala Ala Leu Gln Glu Arg Leu Asp Asn Val 
        35                  40                  45              


Pro His Thr Pro Ser Ser Tyr Ile Glu Thr Leu Pro Lys Ala Val Lys 
    50                  55                  60                  


Arg Arg Ile Asn Ala Leu Lys Gln Leu Gln Val Arg Cys Ala His Ile 
65                  70                  75                  80  


Glu Ala Lys Phe Tyr Glu Glu Val His Asp Leu Glu Arg Lys Tyr Ala 
                85                  90                  95      


Ala Leu Tyr Gln Pro Leu Phe Asp Lys Arg Arg Glu Phe Ile Thr Gly 
            100                 105                 110         


Asp Val Glu Pro Thr Asp Ala Glu Ser Glu Trp His Ser Glu Asn Glu 
        115                 120                 125             


Glu Glu Glu Lys Leu Ala Gly Asp Met Lys Ser Lys Val Val Val Thr 
    130                 135                 140                 


Glu Lys Ala Ala Ala Thr Ala Glu Glu Pro Asp Pro Lys Gly Ile Pro 
145                 150                 155                 160 


Glu Phe Trp Phe Thr Ile Phe Arg Asn Val Asp Met Leu Ser Glu Leu 
                165                 170                 175     


Val Gln Glu Tyr Asp Glu Pro Ile Leu Lys His Leu Gln Asp Ile Lys 
            180                 185                 190         


Val Lys Phe Ser Asp Pro Gly Gln Pro Met Ser Phe Val Leu Glu Phe 
        195                 200                 205             


His Phe Glu Pro Asn Asp Tyr Phe Thr Asn Ser Val Leu Thr Lys Thr 
    210                 215                 220                 


Tyr Lys Met Lys Ser Glu Pro Asp Lys Ala Asp Pro Phe Ser Phe Glu 
225                 230                 235                 240 


Gly Pro Glu Ile Val Asp Cys Asp Gly Cys Thr Ile Asp Trp Lys Lys 
                245                 250                 255     


Gly Lys Asn Val Thr Val Lys Thr Ile Lys Lys Lys Gln Lys His Lys 
            260                 265                 270         


Gly Arg Gly Thr Val Arg Thr Ile Thr Lys Gln Val Pro Asn Glu Ser 
        275                 280                 285             


Phe Phe Asn Phe Phe Asn Pro Leu Lys Ala Ser Gly Asp Gly Glu Ser 
    290                 295                 300                 


Leu Asp Glu Asp Ser Glu Phe Thr Leu Ala Ser Asp Phe Glu Ile Gly 
305                 310                 315                 320 


His Phe Phe Arg Glu Arg Ile Val Pro Arg Ala Val Leu Tyr Phe Thr 
                325                 330                 335     


Gly Glu Ala Ile Glu Asp Asp Asp Asn Phe Glu Glu Gly Glu Glu Gly 
            340                 345                 350         


Glu Glu Glu Glu Leu Glu Gly Asp Glu Glu Gly Glu Asp Glu Asp Asp 
        355                 360                 365             


Ala Glu Ile Asn Pro Lys Val 
    370                 375 

<210>  396
<211>  2767
<212>  DNA
<213>  Homo sapiens

<400>  396
acttccgggg cggcggttgc atcagattct aggaagtgtc tgtagccgca gctgcgggtc     60

cgggattccc agccatggca gattcctccg ggcagcaggc tcctgactac aggtccattc    120

tgagcattag tgacgaggca gccagggcac aagccctgaa cgagcacctc agcacgcgta    180

gctatgtcca ggggtactca ctgtcccagg cagacgtgga cgcgttcagg cagctctcgg    240

ccccgcccgc tgacccccag ctcttccacg tggctcggtg gttcaggcac atagaagcgc    300

tcctgggtag cccctgtggc aaaggccagc cctgcaggct ccaagcaagc aaaggccggc    360

gtgtgcagcc ccagtggtcc cctcctgctg ggacccagcc atgcagactc cacctttaca    420

acagcctcac caggaacaag gaagtgttca tacctcaaga tgggaaaaag gtgacgtggt    480

attgctgtgg gccaaccgtc tatgacgcat ctcacatggg gcacgccagg tcctacatct    540

cttttgatat cttgagaaga gtgttgaagg attacttcaa atttgatgtc ttttattgca    600

tgaacattac ggatattgat gacaagatca tcaagagggc ccggcagaac cacctgttcg    660

agcagtatcg ggagaagagg cctgaagcgg cacagctctt ggaggatgtt caggccgccc    720

tgaagccatt ttcagtaaaa ttaaatgaga ccacggatcc cgataaaaag cagatgctcg    780

aacggattca gcacgcagtg cagcttgcca cagagccact tgagaaagct gtgcagtcca    840

gactcacggg agaggaagtc aacagctgtg tggaggtgtt gctggaagaa gccaaggatt    900

tgctctctga ctggctggat tctacacttg gctgtgatgt cactgacaat tccatcttct    960

ccaagctgcc caagttctgg gagggggact tccacagaga catggaagct ctgaatgttc   1020

tccctccaga tgtcttaacc cgggttagtg agtatgtgcc agaaattgtg aactttgtcc   1080

agaagattgt ggacaacggt tacggctatg tctccaatgg gtctgtctac tttgatacag   1140

cgaagtttgc ttctagcgag aagcactcct atgggaagct ggtgcctgag gccgttggag   1200

atcagaaagc ccttcaagaa ggggaaggtg acctgagcat ctctgcagac cgcctgagtg   1260

agaagcgctc tcccaacgac tttgccttat ggaaggcctc taagcccgga gaaccgtcct   1320

ggccgtgccc ttggggaaag ggtcgtccgg gctggcatat cgagtgctcg gccatggcag   1380

gcaccctcct aggggcttcg atggacattc acggaggtgg gttcgacctc cggttccccc   1440

accatgacaa tgagctggca cagtcggagg cctactttga aaacgactgc tgggtcaggt   1500

acttcctgca cacaggccac ctgaccattg caggctgcaa aatgtcaaag tcactaaaaa   1560

acttcatcac cattaaagat gccttgaaaa agcactcagc acggcagttg cggctggcct   1620

tcctcatgca ctcgtggaag gacaccctgg actactccag caacaccatg gagtcagcgc   1680

ttcaatatga gaagttcttg aatgagtttt tcttaaatgt gaaagatatc cttcgcgctc   1740

ctgttgacat cactggtcag tttgagaagt ggggagaaga agaagcagaa ctgaataaga   1800

acttttatga caagaagaca gcaattcaca aagccctctg tgacaatgtt gacacccgca   1860

ccgtcatgga agagatgcgg gccttggtca gtcagtgcaa cctctatatg gcagcccgga   1920

aagccgtgag gaagaggccc aaccaggctc tgctggagaa catcgccctg tacctcaccc   1980

atatgctgaa gatctttggg gccgtagaag aggacagctc cctgggattc ccggtcggag   2040

ggcctggaac cagcctcagt ctcgaggcca cagtcatgcc ctaccttcag gtgttatcag   2100

aattccgaga aggagtgcgg aagattgccc gagagcaaaa agtccctgag attctgcagc   2160

tcagcgatgc cctgcgggac aacatcctgc ccgagcttgg ggtgcggttt gaagaccacg   2220

aaggactgcc cacagtggtg aaactggtag acagaaacac cttattaaaa gagagagaag   2280

aaaagagacg ggttgaagag gagaagagga agaagaaaga ggaggcggcc cggaggaaac   2340

aggaacaaga agcagcaaag ctggccaaga tgaagattcc ccccagtgag atgttcttgt   2400

cagaaaccga caaatactcc aagtttgatg aaaatggtct gcccacacat gacatggagg   2460

gcaaagagct cagcaaaggg caagccaaga agctgaagaa gctcttcgag gctcaggaga   2520

agctctacaa ggaatatctg cagatggccc agaatggaag cttccagtga gggggcacag   2580

gactgacttt ttaaaccatt gtggactagt ggctgctgtc tgcctcagtg acaatgtccc   2640

agcgctccta tcatgtttac agtcaccctt gggtcctaaa ttaagagttg tgttcatgta   2700

ggttcgtgtc gtcgttggct ctgagacatt gataataaat ttttctcaac agtgaaaaaa   2760

aaaaaaa                                                             2767


<210>  397
<211>  831
<212>  PRT
<213>  Homo sapiens

<400>  397


Met Ala Asp Ser Ser Gly Gln Gln Ala Pro Asp Tyr Arg Ser Ile Leu 
1               5                   10                  15      


Ser Ile Ser Asp Glu Ala Ala Arg Ala Gln Ala Leu Asn Glu His Leu 
            20                  25                  30          


Ser Thr Arg Ser Tyr Val Gln Gly Tyr Ser Leu Ser Gln Ala Asp Val 
        35                  40                  45              


Asp Ala Phe Arg Gln Leu Ser Ala Pro Pro Ala Asp Pro Gln Leu Phe 
    50                  55                  60                  


His Val Ala Arg Trp Phe Arg His Ile Glu Ala Leu Leu Gly Ser Pro 
65                  70                  75                  80  


Cys Gly Lys Gly Gln Pro Cys Arg Leu Gln Ala Ser Lys Gly Arg Arg 
                85                  90                  95      


Val Gln Pro Gln Trp Ser Pro Pro Ala Gly Thr Gln Pro Cys Arg Leu 
            100                 105                 110         


His Leu Tyr Asn Ser Leu Thr Arg Asn Lys Glu Val Phe Ile Pro Gln 
        115                 120                 125             


Asp Gly Lys Lys Val Thr Trp Tyr Cys Cys Gly Pro Thr Val Tyr Asp 
    130                 135                 140                 


Ala Ser His Met Gly His Ala Arg Ser Tyr Ile Ser Phe Asp Ile Leu 
145                 150                 155                 160 


Arg Arg Val Leu Lys Asp Tyr Phe Lys Phe Asp Val Phe Tyr Cys Met 
                165                 170                 175     


Asn Ile Thr Asp Ile Asp Asp Lys Ile Ile Lys Arg Ala Arg Gln Asn 
            180                 185                 190         


His Leu Phe Glu Gln Tyr Arg Glu Lys Arg Pro Glu Ala Ala Gln Leu 
        195                 200                 205             


Leu Glu Asp Val Gln Ala Ala Leu Lys Pro Phe Ser Val Lys Leu Asn 
    210                 215                 220                 


Glu Thr Thr Asp Pro Asp Lys Lys Gln Met Leu Glu Arg Ile Gln His 
225                 230                 235                 240 


Ala Val Gln Leu Ala Thr Glu Pro Leu Glu Lys Ala Val Gln Ser Arg 
                245                 250                 255     


Leu Thr Gly Glu Glu Val Asn Ser Cys Val Glu Val Leu Leu Glu Glu 
            260                 265                 270         


Ala Lys Asp Leu Leu Ser Asp Trp Leu Asp Ser Thr Leu Gly Cys Asp 
        275                 280                 285             


Val Thr Asp Asn Ser Ile Phe Ser Lys Leu Pro Lys Phe Trp Glu Gly 
    290                 295                 300                 


Asp Phe His Arg Asp Met Glu Ala Leu Asn Val Leu Pro Pro Asp Val 
305                 310                 315                 320 


Leu Thr Arg Val Ser Glu Tyr Val Pro Glu Ile Val Asn Phe Val Gln 
                325                 330                 335     


Lys Ile Val Asp Asn Gly Tyr Gly Tyr Val Ser Asn Gly Ser Val Tyr 
            340                 345                 350         


Phe Asp Thr Ala Lys Phe Ala Ser Ser Glu Lys His Ser Tyr Gly Lys 
        355                 360                 365             


Leu Val Pro Glu Ala Val Gly Asp Gln Lys Ala Leu Gln Glu Gly Glu 
    370                 375                 380                 


Gly Asp Leu Ser Ile Ser Ala Asp Arg Leu Ser Glu Lys Arg Ser Pro 
385                 390                 395                 400 


Asn Asp Phe Ala Leu Trp Lys Ala Ser Lys Pro Gly Glu Pro Ser Trp 
                405                 410                 415     


Pro Cys Pro Trp Gly Lys Gly Arg Pro Gly Trp His Ile Glu Cys Ser 
            420                 425                 430         


Ala Met Ala Gly Thr Leu Leu Gly Ala Ser Met Asp Ile His Gly Gly 
        435                 440                 445             


Gly Phe Asp Leu Arg Phe Pro His His Asp Asn Glu Leu Ala Gln Ser 
    450                 455                 460                 


Glu Ala Tyr Phe Glu Asn Asp Cys Trp Val Arg Tyr Phe Leu His Thr 
465                 470                 475                 480 


Gly His Leu Thr Ile Ala Gly Cys Lys Met Ser Lys Ser Leu Lys Asn 
                485                 490                 495     


Phe Ile Thr Ile Lys Asp Ala Leu Lys Lys His Ser Ala Arg Gln Leu 
            500                 505                 510         


Arg Leu Ala Phe Leu Met His Ser Trp Lys Asp Thr Leu Asp Tyr Ser 
        515                 520                 525             


Ser Asn Thr Met Glu Ser Ala Leu Gln Tyr Glu Lys Phe Leu Asn Glu 
    530                 535                 540                 


Phe Phe Leu Asn Val Lys Asp Ile Leu Arg Ala Pro Val Asp Ile Thr 
545                 550                 555                 560 


Gly Gln Phe Glu Lys Trp Gly Glu Glu Glu Ala Glu Leu Asn Lys Asn 
                565                 570                 575     


Phe Tyr Asp Lys Lys Thr Ala Ile His Lys Ala Leu Cys Asp Asn Val 
            580                 585                 590         


Asp Thr Arg Thr Val Met Glu Glu Met Arg Ala Leu Val Ser Gln Cys 
        595                 600                 605             


Asn Leu Tyr Met Ala Ala Arg Lys Ala Val Arg Lys Arg Pro Asn Gln 
    610                 615                 620                 


Ala Leu Leu Glu Asn Ile Ala Leu Tyr Leu Thr His Met Leu Lys Ile 
625                 630                 635                 640 


Phe Gly Ala Val Glu Glu Asp Ser Ser Leu Gly Phe Pro Val Gly Gly 
                645                 650                 655     


Pro Gly Thr Ser Leu Ser Leu Glu Ala Thr Val Met Pro Tyr Leu Gln 
            660                 665                 670         


Val Leu Ser Glu Phe Arg Glu Gly Val Arg Lys Ile Ala Arg Glu Gln 
        675                 680                 685             


Lys Val Pro Glu Ile Leu Gln Leu Ser Asp Ala Leu Arg Asp Asn Ile 
    690                 695                 700                 


Leu Pro Glu Leu Gly Val Arg Phe Glu Asp His Glu Gly Leu Pro Thr 
705                 710                 715                 720 


Val Val Lys Leu Val Asp Arg Asn Thr Leu Leu Lys Glu Arg Glu Glu 
                725                 730                 735     


Lys Arg Arg Val Glu Glu Glu Lys Arg Lys Lys Lys Glu Glu Ala Ala 
            740                 745                 750         


Arg Arg Lys Gln Glu Gln Glu Ala Ala Lys Leu Ala Lys Met Lys Ile 
        755                 760                 765             


Pro Pro Ser Glu Met Phe Leu Ser Glu Thr Asp Lys Tyr Ser Lys Phe 
    770                 775                 780                 


Asp Glu Asn Gly Leu Pro Thr His Asp Met Glu Gly Lys Glu Leu Ser 
785                 790                 795                 800 


Lys Gly Gln Ala Lys Lys Leu Lys Lys Leu Phe Glu Ala Gln Glu Lys 
                805                 810                 815     


Leu Tyr Lys Glu Tyr Leu Gln Met Ala Gln Asn Gly Ser Phe Gln 
            820                 825                 830     

<210>  398
<211>  2814
<212>  DNA
<213>  Homo sapiens

<400>  398
acttccgggg cggcggttgc atcagattct aggaagtgtc tgtagccgca gctgcgggtc     60

cgggattccc agccatggca gattcctccg ggcagcaggc tcctgactac aggtccattc    120

tgagcattag tgacgaggca gccagggcac aagccctgaa cgagcacctc agcacgcgta    180

gctatgtcca ggggtactca ctgtcccagg cagacgtgga cgcgttcagg cagctctcgg    240

ccccgcccgc tgacccccag ctcttccacg tggctcggtg gttcaggcac atagaagcgc    300

tcctgggtag cccctgtggc aaaggccagc cctgcaggct ccaagcaagc aaaggccggc    360

gtgtgcagcc ccagtggtcc cctcctgctg ggacccagcc atgcagactc cacctttaca    420

acagcctcac caggaacaag tgtttcttgc atttcttgtg atcgtcattc cttcattcct    480

aacaaaggaa gtgttcatac ctcaagatgg gaaaaaggtg acgtggtatt gctgtgggcc    540

aaccgtctat gacgcatctc acatggggca cgccaggtcc tacatctctt ttgatatctt    600

gagaagagtg ttgaaggatt acttcaaatt tgatgtcttt tattgcatga acattacgga    660

tattgatgac aagatcatca agagggcccg gcagaaccac ctgttcgagc agtatcggga    720

gaagaggcct gaagcggcac agctcttgga ggatgttcag gccgccctga agccattttc    780

agtaaaatta aatgagacca cggatcccga taaaaagcag atgctcgaac ggattcagca    840

cgcagtgcag cttgccacag agccacttga gaaagctgtg cagtccagac tcacgggaga    900

ggaagtcaac agctgtgtgg aggtgttgct ggaagaagcc aaggatttgc tctctgactg    960

gctggattct acacttggct gtgatgtcac tgacaattcc atcttctcca agctgcccaa   1020

gttctgggag ggggacttcc acagagacat ggaagctctg aatgttctcc ctccagatgt   1080

cttaacccgg gttagtgagt atgtgccaga aattgtgaac tttgtccaga agattgtgga   1140

caacggttac ggctatgtct ccaatgggtc tgtctacttt gatacagcga agtttgcttc   1200

tagcgagaag cactcctatg ggaagctggt gcctgaggcc gttggagatc agaaagccct   1260

tcaagaaggg gaaggtgacc tgagcatctc tgcagaccgc ctgagtgaga agcgctctcc   1320

caacgacttt gccttatgga aggcctctaa gcccggagaa ccgtcctggc cgtgcccttg   1380

gggaaagggt cgtccgggct ggcatatcga gtgctcggcc atggcaggca ccctcctagg   1440

ggcttcgatg gacattcacg gaggtgggtt cgacctccgg ttcccccacc atgacaatga   1500

gctggcacag tcggaggcct actttgaaaa cgactgctgg gtcaggtact tcctgcacac   1560

aggccacctg accattgcag gctgcaaaat gtcaaagtca ctaaaaaact tcatcaccat   1620

taaagatgcc ttgaaaaagc actcagcacg gcagttgcgg ctggccttcc tcatgcactc   1680

gtggaaggac accctggact actccagcaa caccatggag tcagcgcttc aatatgagaa   1740

gttcttgaat gagtttttct taaatgtgaa agatatcctt cgcgctcctg ttgacatcac   1800

tggtcagttt gagaagtggg gagaagaaga agcagaactg aataagaact tttatgacaa   1860

gaagacagca attcacaaag ccctctgtga caatgttgac acccgcaccg tcatggaaga   1920

gatgcgggcc ttggtcagtc agtgcaacct ctatatggca gcccggaaag ccgtgaggaa   1980

gaggcccaac caggctctgc tggagaacat cgccctgtac ctcacccata tgctgaagat   2040

ctttggggcc gtagaagagg acagctccct gggattcccg gtcggagggc ctggaaccag   2100

cctcagtctc gaggccacag tcatgcccta ccttcaggtg ttatcagaat tccgagaagg   2160

agtgcggaag attgcccgag agcaaaaagt ccctgagatt ctgcagctca gcgatgccct   2220

gcgggacaac atcctgcccg agcttggggt gcggtttgaa gaccacgaag gactgcccac   2280

agtggtgaaa ctggtagaca gaaacacctt attaaaagag agagaagaaa agagacgggt   2340

tgaagaggag aagaggaaga agaaagagga ggcggcccgg aggaaacagg aacaagaagc   2400

agcaaagctg gccaagatga agattccccc cagtgagatg ttcttgtcag aaaccgacaa   2460

atactccaag tttgatgaaa atggtctgcc cacacatgac atggagggca aagagctcag   2520

caaagggcaa gccaagaagc tgaagaagct cttcgaggct caggagaagc tctacaagga   2580

atatctgcag atggcccaga atggaagctt ccagtgaggg ggcacaggac tgacttttta   2640

aaccattgtg gactagtggc tgctgtctgc ctcagtgaca atgtcccagc gctcctatca   2700

tgtttacagt cacccttggg tcctaaatta agagttgtgt tcatgtaggt tcgtgtcgtc   2760

gttggctctg agacattgat aataaatttt tctcaacagt gaaaaaaaaa aaaa         2814


<210>  399
<211>  738
<212>  PRT
<213>  Homo sapiens

<400>  399


Met Gln Thr Pro Pro Leu Gln Gln Pro His Gln Glu Gln Val Phe Leu 
1               5                   10                  15      


Ala Phe Leu Val Ile Val Ile Pro Ser Phe Leu Thr Lys Glu Val Phe 
            20                  25                  30          


Ile Pro Gln Asp Gly Lys Lys Val Thr Trp Tyr Cys Cys Gly Pro Thr 
        35                  40                  45              


Val Tyr Asp Ala Ser His Met Gly His Ala Arg Ser Tyr Ile Ser Phe 
    50                  55                  60                  


Asp Ile Leu Arg Arg Val Leu Lys Asp Tyr Phe Lys Phe Asp Val Phe 
65                  70                  75                  80  


Tyr Cys Met Asn Ile Thr Asp Ile Asp Asp Lys Ile Ile Lys Arg Ala 
                85                  90                  95      


Arg Gln Asn His Leu Phe Glu Gln Tyr Arg Glu Lys Arg Pro Glu Ala 
            100                 105                 110         


Ala Gln Leu Leu Glu Asp Val Gln Ala Ala Leu Lys Pro Phe Ser Val 
        115                 120                 125             


Lys Leu Asn Glu Thr Thr Asp Pro Asp Lys Lys Gln Met Leu Glu Arg 
    130                 135                 140                 


Ile Gln His Ala Val Gln Leu Ala Thr Glu Pro Leu Glu Lys Ala Val 
145                 150                 155                 160 


Gln Ser Arg Leu Thr Gly Glu Glu Val Asn Ser Cys Val Glu Val Leu 
                165                 170                 175     


Leu Glu Glu Ala Lys Asp Leu Leu Ser Asp Trp Leu Asp Ser Thr Leu 
            180                 185                 190         


Gly Cys Asp Val Thr Asp Asn Ser Ile Phe Ser Lys Leu Pro Lys Phe 
        195                 200                 205             


Trp Glu Gly Asp Phe His Arg Asp Met Glu Ala Leu Asn Val Leu Pro 
    210                 215                 220                 


Pro Asp Val Leu Thr Arg Val Ser Glu Tyr Val Pro Glu Ile Val Asn 
225                 230                 235                 240 


Phe Val Gln Lys Ile Val Asp Asn Gly Tyr Gly Tyr Val Ser Asn Gly 
                245                 250                 255     


Ser Val Tyr Phe Asp Thr Ala Lys Phe Ala Ser Ser Glu Lys His Ser 
            260                 265                 270         


Tyr Gly Lys Leu Val Pro Glu Ala Val Gly Asp Gln Lys Ala Leu Gln 
        275                 280                 285             


Glu Gly Glu Gly Asp Leu Ser Ile Ser Ala Asp Arg Leu Ser Glu Lys 
    290                 295                 300                 


Arg Ser Pro Asn Asp Phe Ala Leu Trp Lys Ala Ser Lys Pro Gly Glu 
305                 310                 315                 320 


Pro Ser Trp Pro Cys Pro Trp Gly Lys Gly Arg Pro Gly Trp His Ile 
                325                 330                 335     


Glu Cys Ser Ala Met Ala Gly Thr Leu Leu Gly Ala Ser Met Asp Ile 
            340                 345                 350         


His Gly Gly Gly Phe Asp Leu Arg Phe Pro His His Asp Asn Glu Leu 
        355                 360                 365             


Ala Gln Ser Glu Ala Tyr Phe Glu Asn Asp Cys Trp Val Arg Tyr Phe 
    370                 375                 380                 


Leu His Thr Gly His Leu Thr Ile Ala Gly Cys Lys Met Ser Lys Ser 
385                 390                 395                 400 


Leu Lys Asn Phe Ile Thr Ile Lys Asp Ala Leu Lys Lys His Ser Ala 
                405                 410                 415     


Arg Gln Leu Arg Leu Ala Phe Leu Met His Ser Trp Lys Asp Thr Leu 
            420                 425                 430         


Asp Tyr Ser Ser Asn Thr Met Glu Ser Ala Leu Gln Tyr Glu Lys Phe 
        435                 440                 445             


Leu Asn Glu Phe Phe Leu Asn Val Lys Asp Ile Leu Arg Ala Pro Val 
    450                 455                 460                 


Asp Ile Thr Gly Gln Phe Glu Lys Trp Gly Glu Glu Glu Ala Glu Leu 
465                 470                 475                 480 


Asn Lys Asn Phe Tyr Asp Lys Lys Thr Ala Ile His Lys Ala Leu Cys 
                485                 490                 495     


Asp Asn Val Asp Thr Arg Thr Val Met Glu Glu Met Arg Ala Leu Val 
            500                 505                 510         


Ser Gln Cys Asn Leu Tyr Met Ala Ala Arg Lys Ala Val Arg Lys Arg 
        515                 520                 525             


Pro Asn Gln Ala Leu Leu Glu Asn Ile Ala Leu Tyr Leu Thr His Met 
    530                 535                 540                 


Leu Lys Ile Phe Gly Ala Val Glu Glu Asp Ser Ser Leu Gly Phe Pro 
545                 550                 555                 560 


Val Gly Gly Pro Gly Thr Ser Leu Ser Leu Glu Ala Thr Val Met Pro 
                565                 570                 575     


Tyr Leu Gln Val Leu Ser Glu Phe Arg Glu Gly Val Arg Lys Ile Ala 
            580                 585                 590         


Arg Glu Gln Lys Val Pro Glu Ile Leu Gln Leu Ser Asp Ala Leu Arg 
        595                 600                 605             


Asp Asn Ile Leu Pro Glu Leu Gly Val Arg Phe Glu Asp His Glu Gly 
    610                 615                 620                 


Leu Pro Thr Val Val Lys Leu Val Asp Arg Asn Thr Leu Leu Lys Glu 
625                 630                 635                 640 


Arg Glu Glu Lys Arg Arg Val Glu Glu Glu Lys Arg Lys Lys Lys Glu 
                645                 650                 655     


Glu Ala Ala Arg Arg Lys Gln Glu Gln Glu Ala Ala Lys Leu Ala Lys 
            660                 665                 670         


Met Lys Ile Pro Pro Ser Glu Met Phe Leu Ser Glu Thr Asp Lys Tyr 
        675                 680                 685             


Ser Lys Phe Asp Glu Asn Gly Leu Pro Thr His Asp Met Glu Gly Lys 
    690                 695                 700                 


Glu Leu Ser Lys Gly Gln Ala Lys Lys Leu Lys Lys Leu Phe Glu Ala 
705                 710                 715                 720 


Gln Glu Lys Leu Tyr Lys Glu Tyr Leu Gln Met Ala Gln Asn Gly Ser 
                725                 730                 735     


Phe Gln 
        

<210>  400
<211>  2528
<212>  DNA
<213>  Homo sapiens

<400>  400
acttccgggg cggcggttgc atcagattct aggaagtgtc tgtagccgca gctgcgggtc     60

cgggattccc agccatggca gattcctccg ggcagcaggg caaaggccgg cgtgtgcagc    120

cccagtggtc ccctcctgct gggacccagc catgcagact ccacctttac aacagcctca    180

ccaggaacaa ggaagtgttc atacctcaag atgggaaaaa ggtgacgtgg tattgctgtg    240

ggccaaccgt ctatgacgca tctcacatgg ggcacgccag gtcctacatc tcttttgata    300

tcttgagaag agtgttgaag gattacttca aatttgatgt cttttattgc atgaacatta    360

cggatattga tgacaagatc atcaagaggg cccggcagaa ccacctgttc gagcagtatc    420

gggagaagag gcctgaagcg gcacagctct tggaggatgt tcaggccgcc ctgaagccat    480

tttcagtaaa attaaatgag accacggatc ccgataaaaa gcagatgctc gaacggattc    540

agcacgcagt gcagcttgcc acagagccac ttgagaaagc tgtgcagtcc agactcacgg    600

gagaggaagt caacagctgt gtggaggtgt tgctggaaga agccaaggat ttgctctctg    660

actggctgga ttctacactt ggctgtgatg tcactgacaa ttccatcttc tccaagctgc    720

ccaagttctg ggagggggac ttccacagag acatggaagc tctgaatgtt ctccctccag    780

atgtcttaac ccgggttagt gagtatgtgc cagaaattgt gaactttgtc cagaagattg    840

tggacaacgg ttacggctat gtctccaatg ggtctgtcta ctttgataca gcgaagtttg    900

cttctagcga gaagcactcc tatgggaagc tggtgcctga ggccgttgga gatcagaaag    960

cccttcaaga aggggaaggt gacctgagca tctctgcaga ccgcctgagt gagaagcgct   1020

ctcccaacga ctttgcctta tggaaggcct ctaagcccgg agaaccgtcc tggccgtgcc   1080

cttggggaaa gggtcgtccg ggctggcata tcgagtgctc ggccatggca ggcaccctcc   1140

taggggcttc gatggacatt cacggaggtg ggttcgacct ccggttcccc caccatgaca   1200

atgagctggc acagtcggag gcctactttg aaaacgactg ctgggtcagg tacttcctgc   1260

acacaggcca cctgaccatt gcaggctgca aaatgtcaaa gtcactaaaa aacttcatca   1320

ccattaaaga tgccttgaaa aagcactcag cacggcagtt gcggctggcc ttcctcatgc   1380

actcgtggaa ggacaccctg gactactcca gcaacaccat ggagtcagcg cttcaatatg   1440

agaagttctt gaatgagttt ttcttaaatg tgaaagatat ccttcgcgct cctgttgaca   1500

tcactggtca gtttgagaag tggggagaag aagaagcaga actgaataag aacttttatg   1560

acaagaagac agcaattcac aaagccctct gtgacaatgt tgacacccgc accgtcatgg   1620

aagagatgcg ggccttggtc agtcagtgca acctctatat ggcagcccgg aaagccgtga   1680

ggaagaggcc caaccaggct ctgctggaga acatcgccct gtacctcacc catatgctga   1740

agatctttgg ggccgtagaa gaggacagct ccctgggatt cccggtcgga gggcctggaa   1800

ccagcctcag tctcgaggcc acagtcatgc cctaccttca ggtgttatca gaattccgag   1860

aaggagtgcg gaagattgcc cgagagcaaa aagtccctga gattctgcag ctcagcgatg   1920

ccctgcggga caacatcctg cccgagcttg gggtgcggtt tgaagaccac gaaggactgc   1980

ccacagtggt gaaactggta gacagaaaca ccttattaaa agagagagaa gaaaagagac   2040

gggttgaaga ggagaagagg aagaagaaag aggaggcggc ccggaggaaa caggaacaag   2100

aagcagcaaa gctggccaag atgaagattc cccccagtga gatgttcttg tcagaaaccg   2160

acaaatactc caagtttgat gaaaatggtc tgcccacaca tgacatggag ggcaaagagc   2220

tcagcaaagg gcaagccaag aagctgaaga agctcttcga ggctcaggag aagctctaca   2280

aggaatatct gcagatggcc cagaatggaa gcttccagtg agggggcaca ggactgactt   2340

tttaaaccat tgtggactag tggctgctgt ctgcctcagt gacaatgtcc cagcgctcct   2400

atcatgttta cagtcaccct tgggtcctaa attaagagtt gtgttcatgt aggttcgtgt   2460

cgtcgttggc tctgagacat tgataataaa tttttctcaa cagtgaaaaa aaaaaaaaaa   2520

aaaaaaaa                                                            2528


<210>  401
<211>  748
<212>  PRT
<213>  Homo sapiens

<400>  401


Met Ala Asp Ser Ser Gly Gln Gln Gly Lys Gly Arg Arg Val Gln Pro 
1               5                   10                  15      


Gln Trp Ser Pro Pro Ala Gly Thr Gln Pro Cys Arg Leu His Leu Tyr 
            20                  25                  30          


Asn Ser Leu Thr Arg Asn Lys Glu Val Phe Ile Pro Gln Asp Gly Lys 
        35                  40                  45              


Lys Val Thr Trp Tyr Cys Cys Gly Pro Thr Val Tyr Asp Ala Ser His 
    50                  55                  60                  


Met Gly His Ala Arg Ser Tyr Ile Ser Phe Asp Ile Leu Arg Arg Val 
65                  70                  75                  80  


Leu Lys Asp Tyr Phe Lys Phe Asp Val Phe Tyr Cys Met Asn Ile Thr 
                85                  90                  95      


Asp Ile Asp Asp Lys Ile Ile Lys Arg Ala Arg Gln Asn His Leu Phe 
            100                 105                 110         


Glu Gln Tyr Arg Glu Lys Arg Pro Glu Ala Ala Gln Leu Leu Glu Asp 
        115                 120                 125             


Val Gln Ala Ala Leu Lys Pro Phe Ser Val Lys Leu Asn Glu Thr Thr 
    130                 135                 140                 


Asp Pro Asp Lys Lys Gln Met Leu Glu Arg Ile Gln His Ala Val Gln 
145                 150                 155                 160 


Leu Ala Thr Glu Pro Leu Glu Lys Ala Val Gln Ser Arg Leu Thr Gly 
                165                 170                 175     


Glu Glu Val Asn Ser Cys Val Glu Val Leu Leu Glu Glu Ala Lys Asp 
            180                 185                 190         


Leu Leu Ser Asp Trp Leu Asp Ser Thr Leu Gly Cys Asp Val Thr Asp 
        195                 200                 205             


Asn Ser Ile Phe Ser Lys Leu Pro Lys Phe Trp Glu Gly Asp Phe His 
    210                 215                 220                 


Arg Asp Met Glu Ala Leu Asn Val Leu Pro Pro Asp Val Leu Thr Arg 
225                 230                 235                 240 


Val Ser Glu Tyr Val Pro Glu Ile Val Asn Phe Val Gln Lys Ile Val 
                245                 250                 255     


Asp Asn Gly Tyr Gly Tyr Val Ser Asn Gly Ser Val Tyr Phe Asp Thr 
            260                 265                 270         


Ala Lys Phe Ala Ser Ser Glu Lys His Ser Tyr Gly Lys Leu Val Pro 
        275                 280                 285             


Glu Ala Val Gly Asp Gln Lys Ala Leu Gln Glu Gly Glu Gly Asp Leu 
    290                 295                 300                 


Ser Ile Ser Ala Asp Arg Leu Ser Glu Lys Arg Ser Pro Asn Asp Phe 
305                 310                 315                 320 


Ala Leu Trp Lys Ala Ser Lys Pro Gly Glu Pro Ser Trp Pro Cys Pro 
                325                 330                 335     


Trp Gly Lys Gly Arg Pro Gly Trp His Ile Glu Cys Ser Ala Met Ala 
            340                 345                 350         


Gly Thr Leu Leu Gly Ala Ser Met Asp Ile His Gly Gly Gly Phe Asp 
        355                 360                 365             


Leu Arg Phe Pro His His Asp Asn Glu Leu Ala Gln Ser Glu Ala Tyr 
    370                 375                 380                 


Phe Glu Asn Asp Cys Trp Val Arg Tyr Phe Leu His Thr Gly His Leu 
385                 390                 395                 400 


Thr Ile Ala Gly Cys Lys Met Ser Lys Ser Leu Lys Asn Phe Ile Thr 
                405                 410                 415     


Ile Lys Asp Ala Leu Lys Lys His Ser Ala Arg Gln Leu Arg Leu Ala 
            420                 425                 430         


Phe Leu Met His Ser Trp Lys Asp Thr Leu Asp Tyr Ser Ser Asn Thr 
        435                 440                 445             


Met Glu Ser Ala Leu Gln Tyr Glu Lys Phe Leu Asn Glu Phe Phe Leu 
    450                 455                 460                 


Asn Val Lys Asp Ile Leu Arg Ala Pro Val Asp Ile Thr Gly Gln Phe 
465                 470                 475                 480 


Glu Lys Trp Gly Glu Glu Glu Ala Glu Leu Asn Lys Asn Phe Tyr Asp 
                485                 490                 495     


Lys Lys Thr Ala Ile His Lys Ala Leu Cys Asp Asn Val Asp Thr Arg 
            500                 505                 510         


Thr Val Met Glu Glu Met Arg Ala Leu Val Ser Gln Cys Asn Leu Tyr 
        515                 520                 525             


Met Ala Ala Arg Lys Ala Val Arg Lys Arg Pro Asn Gln Ala Leu Leu 
    530                 535                 540                 


Glu Asn Ile Ala Leu Tyr Leu Thr His Met Leu Lys Ile Phe Gly Ala 
545                 550                 555                 560 


Val Glu Glu Asp Ser Ser Leu Gly Phe Pro Val Gly Gly Pro Gly Thr 
                565                 570                 575     


Ser Leu Ser Leu Glu Ala Thr Val Met Pro Tyr Leu Gln Val Leu Ser 
            580                 585                 590         


Glu Phe Arg Glu Gly Val Arg Lys Ile Ala Arg Glu Gln Lys Val Pro 
        595                 600                 605             


Glu Ile Leu Gln Leu Ser Asp Ala Leu Arg Asp Asn Ile Leu Pro Glu 
    610                 615                 620                 


Leu Gly Val Arg Phe Glu Asp His Glu Gly Leu Pro Thr Val Val Lys 
625                 630                 635                 640 


Leu Val Asp Arg Asn Thr Leu Leu Lys Glu Arg Glu Glu Lys Arg Arg 
                645                 650                 655     


Val Glu Glu Glu Lys Arg Lys Lys Lys Glu Glu Ala Ala Arg Arg Lys 
            660                 665                 670         


Gln Glu Gln Glu Ala Ala Lys Leu Ala Lys Met Lys Ile Pro Pro Ser 
        675                 680                 685             


Glu Met Phe Leu Ser Glu Thr Asp Lys Tyr Ser Lys Phe Asp Glu Asn 
    690                 695                 700                 


Gly Leu Pro Thr His Asp Met Glu Gly Lys Glu Leu Ser Lys Gly Gln 
705                 710                 715                 720 


Ala Lys Lys Leu Lys Lys Leu Phe Glu Ala Gln Glu Lys Leu Tyr Lys 
                725                 730                 735     


Glu Tyr Leu Gln Met Ala Gln Asn Gly Ser Phe Gln 
            740                 745             

<210>  402
<211>  2536
<212>  DNA
<213>  Homo sapiens

<400>  402
acttccgggg cggcggttgc atcagattct aggaagtgtc tgtagccgca gctgcgggtc     60

cgggattccc agccatggca gattcctccg ggcagcaggg caaaggccgg cgtgtgcagc    120

cccagtggtc ccctcctgct gggacccagc catgcagact ccacctttac aacagcctca    180

ccaggaacaa ggaagtgttc atacctcaag atgggaaaaa ggtgacgtgg tattgctgtg    240

ggccaaccgt ctatgacgca tctcacatgg ggcacgccag gtcctacatc tcttttgata    300

tcttgagaag agtgttgaag gattacttca aatttgatgt cttttattgc atgaacatta    360

cggatattga tgacaagatc atcaagaggg cccggcagaa ccacctgttc gagcagtatc    420

gggagaagag gcctgaagcg gcacagctct tggaggatgt tcaggccgcc ctgaagccat    480

tttcagtaaa attaaatgag accacggatc ccgataaaaa gcagatgctc gaacggattc    540

agcacgcagt gcagcttgcc acagagccac ttgagaaagc tgtgcagtcc agactcacgg    600

gagaggaagt caacagctgt gtggaggtgt tgctggaaga agccaaggat ttgctctctg    660

actggctgga ttctacactt ggctgtgatg tcactgacaa ttccatcttc tccaagctgc    720

ccaagttctg ggagggggac ttccacagag acatggaagc tctgaatgtt ctccctccag    780

atgtcttaac ccgggttagt gagtatgtgc cagaaattgt gaactttgtc cagaagattg    840

tggacaacgg ttacggctat gtctccaatg ggtctgtcta ctttgataca gcgaagtttg    900

cttctagcga gaagcactcc tatgggaagc tggtgcctga ggccgttgga gatcagaaag    960

cccttcaaga aggggaaggt gacctgagca tctctgcaga ccgcctgagt gagaagcgct   1020

ctcccaacga ctttgcctta tggaaggcct ctaagcccgg agaaccgtcc tggccgtgcc   1080

cttggggaaa gggtcgtccg ggctggcata tcgagtgctc ggccatggca ggcaccctcc   1140

taggggcttc gatggacatt cacggaggtg ggttcgacct ccggttcccc caccatgaca   1200

atgagctggc acagtcggag gcctactttg aaaacgactg ctgggtcagg tacttcctgc   1260

acacaggcca cctgaccatt gcaggctgca aaatgtcaaa gtcactaaaa aacttcatca   1320

ccattaaaga tgccttgaaa aagcactcag cacggcagtt gcggctggcc ttcctcatgc   1380

actcgtggaa ggacaccctg gactactcca gcaacaccat ggagtcagcg cttcaatatg   1440

agaagttctt gaatgagttt ttcttaaatg tgaaagatat ccttcgcgct cctgttgaca   1500

tcactggtca gtttgagaag tggggagaag aagaagcaga actgaataag aacttttatg   1560

acaagaagac agcaattcac aaagccctct gtgacaatgt tgacacccgc accgtcatgg   1620

aagagatgcg ggccttggtc agtcagtgca acctctatat ggcagcccgg aaagccgtga   1680

ggaagaggcc caaccaggct ctgctggaga acatcgccct gtacctcacc catatgctga   1740

agatctttgg ggccgtagaa gaggacagct ccctgggatt cccggtcgga gggcctggaa   1800

ccagcctcag tctcgaggcc acagtcatgc cctaccttca ggtgttatca gaattccgag   1860

aaggagtgcg gaagattgcc cgagagcaaa aagtccctga gattctgcag ctcagcgatg   1920

ccctgcggga caacatcctg cccgagcttg gggtgcggtt tgaagaccac gaaggactgc   1980

ccacagtggt gaaactggta gacagaaaca ccttattaaa agagagagaa gaaaagagac   2040

gggttgaaga ggagaagagg aagaagaaag aggaggcggc ccggaggaaa caggaacaag   2100

aagcagcaaa gctggccaag atgaagattc cccccagtga gatgttcttg tcagaaaccg   2160

acaaatactc caagtttgat gaaaatgtaa gcatggtctg cccacacatg acatggaggg   2220

caaagagctc agcaaagggc aagccaagaa gctgaagaag ctcttcgagg ctcaggagaa   2280

gctctacaag gaatatctgc agatggccca gaatggaagc ttccagtgag ggggcacagg   2340

actgactttt taaaccattg tggactagtg gctgctgtct gcctcagtga caatgtccca   2400

gcgctcctat catgtttaca gtcacccttg ggtcctaaat taagagttgt gttcatgtag   2460

gttcgtgtcg tcgttggctc tgagacattg ataataaatt tttctcaaca gtgaaaaaaa   2520

aaaaaaaaaa aaaaaa                                                   2536


<210>  403
<211>  726
<212>  PRT
<213>  Homo sapiens

<400>  403


Met Ala Asp Ser Ser Gly Gln Gln Gly Lys Gly Arg Arg Val Gln Pro 
1               5                   10                  15      


Gln Trp Ser Pro Pro Ala Gly Thr Gln Pro Cys Arg Leu His Leu Tyr 
            20                  25                  30          


Asn Ser Leu Thr Arg Asn Lys Glu Val Phe Ile Pro Gln Asp Gly Lys 
        35                  40                  45              


Lys Val Thr Trp Tyr Cys Cys Gly Pro Thr Val Tyr Asp Ala Ser His 
    50                  55                  60                  


Met Gly His Ala Arg Ser Tyr Ile Ser Phe Asp Ile Leu Arg Arg Val 
65                  70                  75                  80  


Leu Lys Asp Tyr Phe Lys Phe Asp Val Phe Tyr Cys Met Asn Ile Thr 
                85                  90                  95      


Asp Ile Asp Asp Lys Ile Ile Lys Arg Ala Arg Gln Asn His Leu Phe 
            100                 105                 110         


Glu Gln Tyr Arg Glu Lys Arg Pro Glu Ala Ala Gln Leu Leu Glu Asp 
        115                 120                 125             


Val Gln Ala Ala Leu Lys Pro Phe Ser Val Lys Leu Asn Glu Thr Thr 
    130                 135                 140                 


Asp Pro Asp Lys Lys Gln Met Leu Glu Arg Ile Gln His Ala Val Gln 
145                 150                 155                 160 


Leu Ala Thr Glu Pro Leu Glu Lys Ala Val Gln Ser Arg Leu Thr Gly 
                165                 170                 175     


Glu Glu Val Asn Ser Cys Val Glu Val Leu Leu Glu Glu Ala Lys Asp 
            180                 185                 190         


Leu Leu Ser Asp Trp Leu Asp Ser Thr Leu Gly Cys Asp Val Thr Asp 
        195                 200                 205             


Asn Ser Ile Phe Ser Lys Leu Pro Lys Phe Trp Glu Gly Asp Phe His 
    210                 215                 220                 


Arg Asp Met Glu Ala Leu Asn Val Leu Pro Pro Asp Val Leu Thr Arg 
225                 230                 235                 240 


Val Ser Glu Tyr Val Pro Glu Ile Val Asn Phe Val Gln Lys Ile Val 
                245                 250                 255     


Asp Asn Gly Tyr Gly Tyr Val Ser Asn Gly Ser Val Tyr Phe Asp Thr 
            260                 265                 270         


Ala Lys Phe Ala Ser Ser Glu Lys His Ser Tyr Gly Lys Leu Val Pro 
        275                 280                 285             


Glu Ala Val Gly Asp Gln Lys Ala Leu Gln Glu Gly Glu Gly Asp Leu 
    290                 295                 300                 


Ser Ile Ser Ala Asp Arg Leu Ser Glu Lys Arg Ser Pro Asn Asp Phe 
305                 310                 315                 320 


Ala Leu Trp Lys Ala Ser Lys Pro Gly Glu Pro Ser Trp Pro Cys Pro 
                325                 330                 335     


Trp Gly Lys Gly Arg Pro Gly Trp His Ile Glu Cys Ser Ala Met Ala 
            340                 345                 350         


Gly Thr Leu Leu Gly Ala Ser Met Asp Ile His Gly Gly Gly Phe Asp 
        355                 360                 365             


Leu Arg Phe Pro His His Asp Asn Glu Leu Ala Gln Ser Glu Ala Tyr 
    370                 375                 380                 


Phe Glu Asn Asp Cys Trp Val Arg Tyr Phe Leu His Thr Gly His Leu 
385                 390                 395                 400 


Thr Ile Ala Gly Cys Lys Met Ser Lys Ser Leu Lys Asn Phe Ile Thr 
                405                 410                 415     


Ile Lys Asp Ala Leu Lys Lys His Ser Ala Arg Gln Leu Arg Leu Ala 
            420                 425                 430         


Phe Leu Met His Ser Trp Lys Asp Thr Leu Asp Tyr Ser Ser Asn Thr 
        435                 440                 445             


Met Glu Ser Ala Leu Gln Tyr Glu Lys Phe Leu Asn Glu Phe Phe Leu 
    450                 455                 460                 


Asn Val Lys Asp Ile Leu Arg Ala Pro Val Asp Ile Thr Gly Gln Phe 
465                 470                 475                 480 


Glu Lys Trp Gly Glu Glu Glu Ala Glu Leu Asn Lys Asn Phe Tyr Asp 
                485                 490                 495     


Lys Lys Thr Ala Ile His Lys Ala Leu Cys Asp Asn Val Asp Thr Arg 
            500                 505                 510         


Thr Val Met Glu Glu Met Arg Ala Leu Val Ser Gln Cys Asn Leu Tyr 
        515                 520                 525             


Met Ala Ala Arg Lys Ala Val Arg Lys Arg Pro Asn Gln Ala Leu Leu 
    530                 535                 540                 


Glu Asn Ile Ala Leu Tyr Leu Thr His Met Leu Lys Ile Phe Gly Ala 
545                 550                 555                 560 


Val Glu Glu Asp Ser Ser Leu Gly Phe Pro Val Gly Gly Pro Gly Thr 
                565                 570                 575     


Ser Leu Ser Leu Glu Ala Thr Val Met Pro Tyr Leu Gln Val Leu Ser 
            580                 585                 590         


Glu Phe Arg Glu Gly Val Arg Lys Ile Ala Arg Glu Gln Lys Val Pro 
        595                 600                 605             


Glu Ile Leu Gln Leu Ser Asp Ala Leu Arg Asp Asn Ile Leu Pro Glu 
    610                 615                 620                 


Leu Gly Val Arg Phe Glu Asp His Glu Gly Leu Pro Thr Val Val Lys 
625                 630                 635                 640 


Leu Val Asp Arg Asn Thr Leu Leu Lys Glu Arg Glu Glu Lys Arg Arg 
                645                 650                 655     


Val Glu Glu Glu Lys Arg Lys Lys Lys Glu Glu Ala Ala Arg Arg Lys 
            660                 665                 670         


Gln Glu Gln Glu Ala Ala Lys Leu Ala Lys Met Lys Ile Pro Pro Ser 
        675                 680                 685             


Glu Met Phe Leu Ser Glu Thr Asp Lys Tyr Ser Lys Phe Asp Glu Asn 
    690                 695                 700                 


Val Ser Met Val Cys Pro His Met Thr Trp Arg Ala Lys Ser Ser Ala 
705                 710                 715                 720 


Lys Gly Lys Pro Arg Ser 
                725     

<210>  404
<211>  2189
<212>  DNA
<213>  Homo sapiens

<400>  404
aatcaggcac atgtctggag aggagaggac ggcttccggg atctagcggg gcctttgtcc     60

cgacagagct ccacttcctg tccccgcggc tctgtgtccc ctgctagccg taggtcgtgt    120

gacccgcagg caccgggaga tccagaagtg aaacgccagg ctctctggag gccaggagat    180

gactctgttg acgttcaggg atgtggccat agaattctcc ctggaggagt ggaaatgcct    240

ggacctcgct cagcagaatt tgtacaggga tgtgatgttg gagaactaca gaaacttgtt    300

ctccgttggt ctcactgtct gtaagccagg cctgatcacc tgcctggagc aacgaaaaga    360

gccctggaat gtgaagagac aggaggcagc agacggacat ccagctatgt cttctcattt    420

tacccaagac cttctgccag agcagggcat acaagatgca ttcccaaaaa gaatactgag    480

aggatatgga aattgtggcc ttgataattt atatttaagg aaagactggg aaagtttaga    540

tgagtgtaag ttgcaaaaag attataatgg acttaaccaa tgttcatcaa ctacccatag    600

caaaatcttt caatataata aatatgttaa aatctttgat aacttttcaa atttacatag    660

acgtaatata agtaatactg gagagaaacc tttcaaatgt caagaatgtg gcaaatcctt    720

tcaaatgctc tcattcctaa ctgaacatca gaaaattcac actggaaaaa aattccaaaa    780

atgtggagaa tgtggcaaaa cctttatcca gtgctcacac tttactgaac ctgagaacat    840

tgacactgga gagaaacctt acaagtgtca agaatgtaac aacgtcatta aaacttgctc    900

agtccttact aaaaatagaa tttatgccgg aggggaacat tacagatgtg aagaatttgg    960

caaagtattt aaccagtgct cccaccttac tgaacatgag catggtactg aggaaaaacc   1020

ctgcaaatat gaagagtgca gcagtgtctt tatctcttgc tcaagccttt ctaatcaaca   1080

gatgattctt gctggagaga agctctccaa atgtgaaaca tggtacaaag gttttaacca   1140

cagcccaaat ccttccaaac accagagaaa tgagattgga gggaaacctt tcaaatgtga   1200

ggaatgtgac agcatcttca agtggttctc agaccttact aaacataaga gaattcacac   1260

tggtgagaaa ccatacaaat gtgacgaatg tgggaaagcc tatacacagt cctcacacct   1320

cagtgaacac aggaggattc acaccggaga gaaaccctac caatgtgaag aatgtgggaa   1380

ggtcttcaga acttgctcaa gcctttctaa ccataagaga actcattctg aagaaaaacc   1440

ctacacgtgt gaagaatgtg gcaacatctt taagcagtta tcagacctca ctaagcataa   1500

gaaaacccat actggagaga agccctacaa atgtgacgaa tgtggaaaaa actttaccca   1560

gtcctccaac cttattgtac ataagagaat tcatactgga gagaaaccct acaagtgtga   1620

agaatgtggc agagtcttca tgtggttctc agacattacc aaacataaga aaacccatac   1680

tggagagaaa ccctacaaat gtgacgaatg tggaaaaaac tttacccagt cctcaaacct   1740

tattgtacat aagagaattc atactggaga gaaaccctac aagtgtgaaa agtgtggcaa   1800

agccttcacc cagttctcac acctgactgt acatgaaagc attcatactt gagaaaaaaa   1860

taaacaaata taaaaatagg caaagccgtt agtatctgct cgcatcccac tttacatcag   1920

agttcagact taataaagtt atcataaatg taattactat tgaaagacct ttcatgaaat   1980

ataagtctcc agagcacaca agagtatttc ttctgaaaaa aatgttacaa ttatactaga   2040

tggaagactt gcatcagttg cttaaacttt cagaaaattt gtagagaaac ccaacaaatc   2100

tcataaatgt ggaataacat ttgttcaaaa atgatagctt agaaaacact agagttcata   2160

ctaaaagata ttttgcaaat acactaaat                                     2189


<210>  405
<211>  557
<212>  PRT
<213>  Homo sapiens

<400>  405


Met Thr Leu Leu Thr Phe Arg Asp Val Ala Ile Glu Phe Ser Leu Glu 
1               5                   10                  15      


Glu Trp Lys Cys Leu Asp Leu Ala Gln Gln Asn Leu Tyr Arg Asp Val 
            20                  25                  30          


Met Leu Glu Asn Tyr Arg Asn Leu Phe Ser Val Gly Leu Thr Val Cys 
        35                  40                  45              


Lys Pro Gly Leu Ile Thr Cys Leu Glu Gln Arg Lys Glu Pro Trp Asn 
    50                  55                  60                  


Val Lys Arg Gln Glu Ala Ala Asp Gly His Pro Ala Met Ser Ser His 
65                  70                  75                  80  


Phe Thr Gln Asp Leu Leu Pro Glu Gln Gly Ile Gln Asp Ala Phe Pro 
                85                  90                  95      


Lys Arg Ile Leu Arg Gly Tyr Gly Asn Cys Gly Leu Asp Asn Leu Tyr 
            100                 105                 110         


Leu Arg Lys Asp Trp Glu Ser Leu Asp Glu Cys Lys Leu Gln Lys Asp 
        115                 120                 125             


Tyr Asn Gly Leu Asn Gln Cys Ser Ser Thr Thr His Ser Lys Ile Phe 
    130                 135                 140                 


Gln Tyr Asn Lys Tyr Val Lys Ile Phe Asp Asn Phe Ser Asn Leu His 
145                 150                 155                 160 


Arg Arg Asn Ile Ser Asn Thr Gly Glu Lys Pro Phe Lys Cys Gln Glu 
                165                 170                 175     


Cys Gly Lys Ser Phe Gln Met Leu Ser Phe Leu Thr Glu His Gln Lys 
            180                 185                 190         


Ile His Thr Gly Lys Lys Phe Gln Lys Cys Gly Glu Cys Gly Lys Thr 
        195                 200                 205             


Phe Ile Gln Cys Ser His Phe Thr Glu Pro Glu Asn Ile Asp Thr Gly 
    210                 215                 220                 


Glu Lys Pro Tyr Lys Cys Gln Glu Cys Asn Asn Val Ile Lys Thr Cys 
225                 230                 235                 240 


Ser Val Leu Thr Lys Asn Arg Ile Tyr Ala Gly Gly Glu His Tyr Arg 
                245                 250                 255     


Cys Glu Glu Phe Gly Lys Val Phe Asn Gln Cys Ser His Leu Thr Glu 
            260                 265                 270         


His Glu His Gly Thr Glu Glu Lys Pro Cys Lys Tyr Glu Glu Cys Ser 
        275                 280                 285             


Ser Val Phe Ile Ser Cys Ser Ser Leu Ser Asn Gln Gln Met Ile Leu 
    290                 295                 300                 


Ala Gly Glu Lys Leu Ser Lys Cys Glu Thr Trp Tyr Lys Gly Phe Asn 
305                 310                 315                 320 


His Ser Pro Asn Pro Ser Lys His Gln Arg Asn Glu Ile Gly Gly Lys 
                325                 330                 335     


Pro Phe Lys Cys Glu Glu Cys Asp Ser Ile Phe Lys Trp Phe Ser Asp 
            340                 345                 350         


Leu Thr Lys His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys 
        355                 360                 365             


Asp Glu Cys Gly Lys Ala Tyr Thr Gln Ser Ser His Leu Ser Glu His 
    370                 375                 380                 


Arg Arg Ile His Thr Gly Glu Lys Pro Tyr Gln Cys Glu Glu Cys Gly 
385                 390                 395                 400 


Lys Val Phe Arg Thr Cys Ser Ser Leu Ser Asn His Lys Arg Thr His 
                405                 410                 415     


Ser Glu Glu Lys Pro Tyr Thr Cys Glu Glu Cys Gly Asn Ile Phe Lys 
            420                 425                 430         


Gln Leu Ser Asp Leu Thr Lys His Lys Lys Thr His Thr Gly Glu Lys 
        435                 440                 445             


Pro Tyr Lys Cys Asp Glu Cys Gly Lys Asn Phe Thr Gln Ser Ser Asn 
    450                 455                 460                 


Leu Ile Val His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys 
465                 470                 475                 480 


Glu Glu Cys Gly Arg Val Phe Met Trp Phe Ser Asp Ile Thr Lys His 
                485                 490                 495     


Lys Lys Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly 
            500                 505                 510         


Lys Asn Phe Thr Gln Ser Ser Asn Leu Ile Val His Lys Arg Ile His 
        515                 520                 525             


Thr Gly Glu Lys Pro Tyr Lys Cys Glu Lys Cys Gly Lys Ala Phe Thr 
    530                 535                 540                 


Gln Phe Ser His Leu Thr Val His Glu Ser Ile His Thr 
545                 550                 555         

<210>  406
<211>  7447
<212>  DNA
<213>  Homo sapiens

<400>  406
ggttgtcaaa catggctgaa gcgctgccgc tgccgctact gccgctgcag ggaaaatgct     60

gagccctccc gggccgggtg ggcggcggcg gcgagggcgg cgacggggac ccgcttcccg    120

agcgcggcgg cggcggccat ggcccggctg gctgactact tcatcgtggt aggctatgac    180

cacgagaagc caggatcagg agaaggtctg gggaaaataa tccagagatt tccacagaag    240

gactgggatg atacaccttt tccacaggga attgagttgt tttgtcagcc tggcgggtgg    300

cagctgtcca gagagaggaa gcagccaacg ttctttgtgg ttgtcctgac agacattgac    360

tcagatcgac attactgctc atgcctaacc ttctatgagg cagagatcaa tcttcaggga    420

acaaagaagg aagagattga aggtgaagca aaagtgtctg gtttaattca gcctgcagaa    480

gtgtttgctc ccaaaagcct ggtgttggta tccagattat attatccaga aatttttagg    540

gcttgcctgg gtttgatcta taccgtgtat gtggacagcc tgaatgtctc cttggaaagt    600

ctaattgcaa acctttgtgc ctgccttgtc ccagcggctg gagggtctca gaagctgttt    660

tctttgggtg caggagatag acagttgatc cagactcctt tacatgatag tcttcctatc    720

acgggcacta gtgtggctct cctgttccag caattgggaa ttcaaaatgt cctcagcctc    780

ttttgtgcag tcctcacaga aaataaggtt ctcttccatt ctgcaagttt ccagagactt    840

agtgatgctt gtagagccct ggaatcttta atgtttcctc ttaaatatag ttatccttat    900

atccctattc tcccggctca gctactggaa gttctaagtt ccccaacgcc tttcattatt    960

ggagtacatt ctgtctttaa aactgatgtc catgaacttt tagatgtaat catagcagat   1020

ttggatggag gcactattaa aattcccgaa tgtattcacc tctcttccct cccagaacca   1080

cttctacatc agactcaatc agctctttct ttgattttac acccagattt ggaagtagca   1140

gatcatgctt ttcctcctcc acgaacagct ttatcccact caaaaatgct ggataaagag   1200

gtgcgagccg ttttccttag attatttgca caactcttcc aaggatatag atcctgcctg   1260

caacttataa gaattcatgc agagccagta atacatttcc acaagacagc attcttgggg   1320

cagcgtggtt tggtcgagaa tgatttcctc actaaagtac tcagtggaat ggcatttgca   1380

ggttttgttt cagaaagagg tcctccttat agatcttgtg atctctttga tgagttggta   1440

gcctttgaag tagagagaat taaagttgaa gaaaataacc cagtgaagat gataaagcat   1500

gtcagggaac ttgctgagca actattcaaa aatgagaatc caaatcctca tatggcattc   1560

cagaaagttc cacggccaac agaaggatcc catttgcgag ttcatattct tcctttccca   1620

gagattaatg aagcccgggt tcaggaatta atacaggaaa atgttgctaa gaaccagaat   1680

gcacctcctg ccacacgaat agaaaagaaa tgtgttgtgc cagcaggtcc acctgttgtt   1740

tcgataatgg acaaggtgac gacagttttc aacagtgcac aaagactaga agttgtcaga   1800

aactgtatct cattcatatt tgaaaataaa attttggaaa ctgaaaagac ccttcctgct   1860

gcactcagag cccttaaagg aaaggcagca agacagtgtc tcactgatga attgggtttg   1920

catgtccagc aaaaccgggc aatattagac catcaacagt ttgactacat aataaggatg   1980

atgaattgta ctctacagga ttgttcaagt ttagaagaat acaacattgc cgcagcatta   2040

ctccctttga ccagtgcttt ctataggaaa cttgcccctg gagtcagcca gtttgcttac   2100

acgtgtgtac aagaccaccc catttggaca aatcagcaat tttgggagac aaccttttac   2160

aatgcagtgc aggaacaggt tcgctccctt tatctctcag ccaaggaaga caatcatgcc   2220

ccgcatctga agcaaaagga taagcttcct gatgaccatt atcaggagaa gacagcaatg   2280

gacctggcag ctgagcaact acgcctttgg cctaccctga gcaagtcaac tcagcaagag   2340

ctagtgcaac atgaggaaag cactgtcttt agtcaggcca ttcactttgc aaacctcatg   2400

gtgaacctgc tagttccact cgacacaagt aaaaacaagc tcctaagaac atcagcgcca   2460

ggtgactggg agagcggaag caacagcatt gtcacaaaca gtattgcagg aagtgtagct   2520

gagagctatg atacagagag tgggtttgaa gattcagaga atactgacat tgccaattct   2580

gttgtgcggt tcattacccg atttattgac aaagtttgta cagagagtgg agttactcag   2640

gatcacatca agagccttca ttgcatgata ccaggaattg tagctatgca cattgagacc   2700

ctagaagcag tacatcgaga aagcagaaga cttccgccta ttcagaagcc caagattctt   2760

agacctgctc tgctgccagg agaagaaatt gtctgtgagg gtcttcgagt cttgctggat   2820

cctgatggaa gagaagaagc tactggaggt cttcttggag gccctcagct cctgccagca   2880

gaaggagcct tgttcctcac cacatacaga attctcttca gaggaacacc ccatgatcag   2940

ttagtgggtg agcagacagt tgtgcggagc tttcccattg cctccatcac caaggagaag   3000

aagattacaa tgcagaacca gctacagcag aacatgcaag aaggactgca gatcacatca   3060

gcatcttttc agttgattaa ggtagcattt gatgaagaag tcagtccaga agtagtagag   3120

atctttaaga aacagctgat gaagttccgt tatcctcagt ccattttcag tacctttgct   3180

tttgctgctg gacaaactac cccacaaata attttaccaa aacagaagga aaagaacact   3240

tcttttcgta ccttctcaaa aacaattgtg aaaggtgcca aaagggcagg gaaaatgaca   3300

attgggcggc aatatttact gaagaagaag acagggacaa ttgtggaaga aagagtaaat   3360

cgtcctggat ggaatgaaga tgatgatgta tctgtttcag atgagagtga gctccccaca   3420

agtaccaccc tgaaggcctc cgagaagtct acaatggaac agttggtgga aaaagcttgt   3480

ttcagagact atcagcgttt aggtttagga accataagtg gcagctcttc ccgttcaaga   3540

cccgagtatt ttagaattac tgcctccaac aggatgtatt cactctgccg gagctatcct   3600

ggccttttag tcgtacctca agctgtacag gacagtagtt taccaagagt agctcgctgc   3660

tatcgacaca atcgcctgcc tgttgtatgt tggaagaact caagaagtgg tactctgctc   3720

ctccgatctg gaggattcca tgggaaggga gtcgttggtc ttttcaaatc tcagaactcc   3780

cctcaggccg ctcctacctc ctctttagaa tcttccagta gcatagaaca agagaaatac   3840

ttgcaagcct tactgaatgc tgtttctgtc catcagaaac tcagaggcaa cagcactctt   3900

actgtcaggc cagcctttgc tctatctcca ggtgtgtggg caagtcttcg ctctagcact   3960

cgcttgatca gctctccaac atccttcatt gatgttggcg cccggctggc aggcaaggat   4020

cactcggcct ccttcagtaa cagcagctac ctacaaaacc agctcttgaa acggcaagca   4080

gccctttaca tatttggtga aaagtcgcaa ctaaggaact tcaaggtaga atttgcttta   4140

aattgtgagt ttgttcctgt tgaatttcat gaaatccggc aagtgaaagc cagttttaag   4200

aagctgatga gggcttgtat cccaagcacc atccctactg actcagaagt gaccttcctg   4260

aaagcgctgg gagattctga gtggttccca cagcttcaca ggataatgca gctggctgtg   4320

gttgtatcag aagtacttga gaatggttcc tcagttttgg tctgtttgga ggaaggctgg   4380

gacatcactg cacaagtgac atccctggtt cagttactca gtgatccctt ttataggaca   4440

cttgaaggct tccagatgtt ggttgaaaaa gagtggctct cttttggtca caaattcagt   4500

cagaggagca gcttgaccct caactgtcag gggagtggtt ttgctccagt cttcttacag   4560

ttcttagact gtgtacacca ggttcacaac cagtatccaa ctgagtttga attcaatctc   4620

tattacttaa agttcttggc tttccactat gtgtctaatc gctttaaaac atttctcctg   4680

gattcagact atgaaagatt agagcacgga actttatttg atgataaagg agaaaagcat   4740

gccaaaaaag gagtctgtat ttgggaatgt attgacagaa tgcacaagag gagtcccatt   4800

ttctttaatt atttatattc accattggaa atagaggctc taaagcccaa tgtaaacgtc   4860

tctagcctca agaagtggga ttactacata gaagagaccc tgtccacagg cccttcctat   4920

gactggatga tgctaacccc caagcacttc ccctccgaag actctgacct ggctggagaa   4980

gctgggccac ggagccagag gagaacagtg tggccatgct atgatgatgt cagctgtact   5040

cagcctgatg ctctcaccag ccttttcagt gaaattgaaa aattggagca caaattgaac   5100

caagcccctg agaagtggca gcagctgtgg gaaagggtaa ccgtggacct taaagaagaa   5160

ccaagaacag atcgctccca aagacacctg tcgagatccc caggaattgt gtctaccaac   5220

ctaccttcct atcagaagag gtctctgcta catctcccag acagcagcat gggggaggaa   5280

cagaattcca gcatctcccc atccaatgga gtggagcgaa gagcagccac gctctatagc   5340

cagtatacat ccaagaatga tgaaaacagg tcctttgagg gaacacttta taaaagaggg   5400

gctttgctga aaggttggaa gccccgttgg tttgttttgg atgtaacaaa acatcagctg   5460

cgctactatg actcaggtga ggacacaagc tgtaaaggcc acattgatct ggctgaagta   5520

gaaatggtca tccctgctgg ccccagcatg ggagccccaa agcacacaag tgacaaggct   5580

ttctttgatc tcaagaccag caaacgtgtg tataacttct gcgcccagga tggacagagt   5640

gcccagcaat ggatggacaa gatccagagt tgtatctctg atgcctgatg cccatggtca   5700

acccacgcag aagaaacaga agaactcatg ctgccagata gatagaaaaa gaagcatgga   5760

tccttgagga gctgacaaca agttatccca gggcctgagg ttctcctgcc cagtcccctc   5820

ttgcaggggt tgctatatct acttaacctg aataggtgtt tcacacaggt ctggtcaaca   5880

gccccatgca ctccctgtat cttgcactaa atttttctaa cagggtctta gtggttaatg   5940

atcagaagat gtctcctgag ccaactgtga acctcaccca ggcaaaatgg ctaccaccta   6000

cttgggtcct tcttcatgaa agctatagat ccttttttgt tctctgaggt cataatttcc   6060

tcggagacct gtttaacaag caaaaatcaa aaccctccaa gattgtctca tattctacct   6120

ggactaggtt tcctatgaga gacatctact tgtaatgcct gacctttgag atgctcagtt   6180

ctctggtgct gccaaaagat gcttccatgg tccgtgctct gccagtgggg ttcacaacaa   6240

gagacgtcat tgttcagtag caggcaaaga gggagcacac agcattattc tgatggaaaa   6300

agattatcca gggaatggta caacaatgac cagcccaatg caggaaaaca ctacttccaa   6360

aacactgaat tctctagacc agaggtgctc tgaggatcca gggccttgtg ttcttatgta   6420

tcttctgctt cctgacagct tctttttcaa aataacatgc aaaaaaagct gaatgcacta   6480

actcacaaaa caaacacttg cactgaattc ccaatgaagt gaagatgttg gaaagacaga   6540

ggccagctat ttaggaccat acgcacctgt gacaagggct gtgttgacca cagtcacact   6600

gtggcatgac tggataccca aactacactt ctacacatga aaagtaagaa ctgtctttag   6660

attttcttta ctttgataac ttgtgattgt ttagcttaag acccaagaaa tgctgtttgc   6720

tcatggtaaa cagaaacagc atcttcgcta caaccactga caccagctgg cgtcataggt   6780

agctagatca ttgcatttgt tttgaaatgt taatatgtta aatactaaac taatatttca   6840

aaaatgtgta tatatgattt ctatatcctt gtttttcaga tagcctgctt ataatttaat   6900

ataaattaac tgatgcattc ataagatttc aataatgaaa tggttccctt ttaaaaaata   6960

aaaatacttt gtagattaaa aataaatcag aatttcaaat ttaaaattgt ccacacacta   7020

ggaaatagaa ctgtgttaat atataagaaa tctggggata attaagaatg aaggactttt   7080

ctatcatttc cattttataa attgccacct gtgaaaatgg tttttgcaca ttatttgtat   7140

ttttctttgt atatgaaata attttttgta ctttgtaaaa tatggagccc attgtacctt   7200

cagctatttg agactataca cagtgcttct tttgtaactg gattacttta actttcgtga   7260

aggcattaca ttgcctcaca ttcactaacc accttgaatt aaatttattt cttaagaaaa   7320

agcatccctc atttactgtg aactaaagtt cattctgtag tgcacagcat tcaggagggt   7380

aacactcagg attcatacat gggactaaag gttcaagaat aaaacaaagc atgacccaca   7440

aaaaaaa                                                             7447


<210>  407
<211>  1849
<212>  PRT
<213>  Homo sapiens

<400>  407


Met Ala Arg Leu Ala Asp Tyr Phe Ile Val Val Gly Tyr Asp His Glu 
1               5                   10                  15      


Lys Pro Gly Ser Gly Glu Gly Leu Gly Lys Ile Ile Gln Arg Phe Pro 
            20                  25                  30          


Gln Lys Asp Trp Asp Asp Thr Pro Phe Pro Gln Gly Ile Glu Leu Phe 
        35                  40                  45              


Cys Gln Pro Gly Gly Trp Gln Leu Ser Arg Glu Arg Lys Gln Pro Thr 
    50                  55                  60                  


Phe Phe Val Val Val Leu Thr Asp Ile Asp Ser Asp Arg His Tyr Cys 
65                  70                  75                  80  


Ser Cys Leu Thr Phe Tyr Glu Ala Glu Ile Asn Leu Gln Gly Thr Lys 
                85                  90                  95      


Lys Glu Glu Ile Glu Gly Glu Ala Lys Val Ser Gly Leu Ile Gln Pro 
            100                 105                 110         


Ala Glu Val Phe Ala Pro Lys Ser Leu Val Leu Val Ser Arg Leu Tyr 
        115                 120                 125             


Tyr Pro Glu Ile Phe Arg Ala Cys Leu Gly Leu Ile Tyr Thr Val Tyr 
    130                 135                 140                 


Val Asp Ser Leu Asn Val Ser Leu Glu Ser Leu Ile Ala Asn Leu Cys 
145                 150                 155                 160 


Ala Cys Leu Val Pro Ala Ala Gly Gly Ser Gln Lys Leu Phe Ser Leu 
                165                 170                 175     


Gly Ala Gly Asp Arg Gln Leu Ile Gln Thr Pro Leu His Asp Ser Leu 
            180                 185                 190         


Pro Ile Thr Gly Thr Ser Val Ala Leu Leu Phe Gln Gln Leu Gly Ile 
        195                 200                 205             


Gln Asn Val Leu Ser Leu Phe Cys Ala Val Leu Thr Glu Asn Lys Val 
    210                 215                 220                 


Leu Phe His Ser Ala Ser Phe Gln Arg Leu Ser Asp Ala Cys Arg Ala 
225                 230                 235                 240 


Leu Glu Ser Leu Met Phe Pro Leu Lys Tyr Ser Tyr Pro Tyr Ile Pro 
                245                 250                 255     


Ile Leu Pro Ala Gln Leu Leu Glu Val Leu Ser Ser Pro Thr Pro Phe 
            260                 265                 270         


Ile Ile Gly Val His Ser Val Phe Lys Thr Asp Val His Glu Leu Leu 
        275                 280                 285             


Asp Val Ile Ile Ala Asp Leu Asp Gly Gly Thr Ile Lys Ile Pro Glu 
    290                 295                 300                 


Cys Ile His Leu Ser Ser Leu Pro Glu Pro Leu Leu His Gln Thr Gln 
305                 310                 315                 320 


Ser Ala Leu Ser Leu Ile Leu His Pro Asp Leu Glu Val Ala Asp His 
                325                 330                 335     


Ala Phe Pro Pro Pro Arg Thr Ala Leu Ser His Ser Lys Met Leu Asp 
            340                 345                 350         


Lys Glu Val Arg Ala Val Phe Leu Arg Leu Phe Ala Gln Leu Phe Gln 
        355                 360                 365             


Gly Tyr Arg Ser Cys Leu Gln Leu Ile Arg Ile His Ala Glu Pro Val 
    370                 375                 380                 


Ile His Phe His Lys Thr Ala Phe Leu Gly Gln Arg Gly Leu Val Glu 
385                 390                 395                 400 


Asn Asp Phe Leu Thr Lys Val Leu Ser Gly Met Ala Phe Ala Gly Phe 
                405                 410                 415     


Val Ser Glu Arg Gly Pro Pro Tyr Arg Ser Cys Asp Leu Phe Asp Glu 
            420                 425                 430         


Leu Val Ala Phe Glu Val Glu Arg Ile Lys Val Glu Glu Asn Asn Pro 
        435                 440                 445             


Val Lys Met Ile Lys His Val Arg Glu Leu Ala Glu Gln Leu Phe Lys 
    450                 455                 460                 


Asn Glu Asn Pro Asn Pro His Met Ala Phe Gln Lys Val Pro Arg Pro 
465                 470                 475                 480 


Thr Glu Gly Ser His Leu Arg Val His Ile Leu Pro Phe Pro Glu Ile 
                485                 490                 495     


Asn Glu Ala Arg Val Gln Glu Leu Ile Gln Glu Asn Val Ala Lys Asn 
            500                 505                 510         


Gln Asn Ala Pro Pro Ala Thr Arg Ile Glu Lys Lys Cys Val Val Pro 
        515                 520                 525             


Ala Gly Pro Pro Val Val Ser Ile Met Asp Lys Val Thr Thr Val Phe 
    530                 535                 540                 


Asn Ser Ala Gln Arg Leu Glu Val Val Arg Asn Cys Ile Ser Phe Ile 
545                 550                 555                 560 


Phe Glu Asn Lys Ile Leu Glu Thr Glu Lys Thr Leu Pro Ala Ala Leu 
                565                 570                 575     


Arg Ala Leu Lys Gly Lys Ala Ala Arg Gln Cys Leu Thr Asp Glu Leu 
            580                 585                 590         


Gly Leu His Val Gln Gln Asn Arg Ala Ile Leu Asp His Gln Gln Phe 
        595                 600                 605             


Asp Tyr Ile Ile Arg Met Met Asn Cys Thr Leu Gln Asp Cys Ser Ser 
    610                 615                 620                 


Leu Glu Glu Tyr Asn Ile Ala Ala Ala Leu Leu Pro Leu Thr Ser Ala 
625                 630                 635                 640 


Phe Tyr Arg Lys Leu Ala Pro Gly Val Ser Gln Phe Ala Tyr Thr Cys 
                645                 650                 655     


Val Gln Asp His Pro Ile Trp Thr Asn Gln Gln Phe Trp Glu Thr Thr 
            660                 665                 670         


Phe Tyr Asn Ala Val Gln Glu Gln Val Arg Ser Leu Tyr Leu Ser Ala 
        675                 680                 685             


Lys Glu Asp Asn His Ala Pro His Leu Lys Gln Lys Asp Lys Leu Pro 
    690                 695                 700                 


Asp Asp His Tyr Gln Glu Lys Thr Ala Met Asp Leu Ala Ala Glu Gln 
705                 710                 715                 720 


Leu Arg Leu Trp Pro Thr Leu Ser Lys Ser Thr Gln Gln Glu Leu Val 
                725                 730                 735     


Gln His Glu Glu Ser Thr Val Phe Ser Gln Ala Ile His Phe Ala Asn 
            740                 745                 750         


Leu Met Val Asn Leu Leu Val Pro Leu Asp Thr Ser Lys Asn Lys Leu 
        755                 760                 765             


Leu Arg Thr Ser Ala Pro Gly Asp Trp Glu Ser Gly Ser Asn Ser Ile 
    770                 775                 780                 


Val Thr Asn Ser Ile Ala Gly Ser Val Ala Glu Ser Tyr Asp Thr Glu 
785                 790                 795                 800 


Ser Gly Phe Glu Asp Ser Glu Asn Thr Asp Ile Ala Asn Ser Val Val 
                805                 810                 815     


Arg Phe Ile Thr Arg Phe Ile Asp Lys Val Cys Thr Glu Ser Gly Val 
            820                 825                 830         


Thr Gln Asp His Ile Lys Ser Leu His Cys Met Ile Pro Gly Ile Val 
        835                 840                 845             


Ala Met His Ile Glu Thr Leu Glu Ala Val His Arg Glu Ser Arg Arg 
    850                 855                 860                 


Leu Pro Pro Ile Gln Lys Pro Lys Ile Leu Arg Pro Ala Leu Leu Pro 
865                 870                 875                 880 


Gly Glu Glu Ile Val Cys Glu Gly Leu Arg Val Leu Leu Asp Pro Asp 
                885                 890                 895     


Gly Arg Glu Glu Ala Thr Gly Gly Leu Leu Gly Gly Pro Gln Leu Leu 
            900                 905                 910         


Pro Ala Glu Gly Ala Leu Phe Leu Thr Thr Tyr Arg Ile Leu Phe Arg 
        915                 920                 925             


Gly Thr Pro His Asp Gln Leu Val Gly Glu Gln Thr Val Val Arg Ser 
    930                 935                 940                 


Phe Pro Ile Ala Ser Ile Thr Lys Glu Lys Lys Ile Thr Met Gln Asn 
945                 950                 955                 960 


Gln Leu Gln Gln Asn Met Gln Glu Gly Leu Gln Ile Thr Ser Ala Ser 
                965                 970                 975     


Phe Gln Leu Ile Lys Val Ala Phe Asp Glu Glu Val Ser Pro Glu Val 
            980                 985                 990         


Val Glu Ile Phe Lys Lys Gln Leu  Met Lys Phe Arg Tyr  Pro Gln Ser 
        995                 1000                 1005             


Ile Phe  Ser Thr Phe Ala Phe  Ala Ala Gly Gln Thr  Thr Pro Gln 
    1010                 1015                 1020             


Ile Ile  Leu Pro Lys Gln Lys  Glu Lys Asn Thr Ser  Phe Arg Thr 
    1025                 1030                 1035             


Phe Ser  Lys Thr Ile Val Lys  Gly Ala Lys Arg Ala  Gly Lys Met 
    1040                 1045                 1050             


Thr Ile  Gly Arg Gln Tyr Leu  Leu Lys Lys Lys Thr  Gly Thr Ile 
    1055                 1060                 1065             


Val Glu  Glu Arg Val Asn Arg  Pro Gly Trp Asn Glu  Asp Asp Asp 
    1070                 1075                 1080             


Val Ser  Val Ser Asp Glu Ser  Glu Leu Pro Thr Ser  Thr Thr Leu 
    1085                 1090                 1095             


Lys Ala  Ser Glu Lys Ser Thr  Met Glu Gln Leu Val  Glu Lys Ala 
    1100                 1105                 1110             


Cys Phe  Arg Asp Tyr Gln Arg  Leu Gly Leu Gly Thr  Ile Ser Gly 
    1115                 1120                 1125             


Ser Ser  Ser Arg Ser Arg Pro  Glu Tyr Phe Arg Ile  Thr Ala Ser 
    1130                 1135                 1140             


Asn Arg  Met Tyr Ser Leu Cys  Arg Ser Tyr Pro Gly  Leu Leu Val 
    1145                 1150                 1155             


Val Pro  Gln Ala Val Gln Asp  Ser Ser Leu Pro Arg  Val Ala Arg 
    1160                 1165                 1170             


Cys Tyr  Arg His Asn Arg Leu  Pro Val Val Cys Trp  Lys Asn Ser 
    1175                 1180                 1185             


Arg Ser  Gly Thr Leu Leu Leu  Arg Ser Gly Gly Phe  His Gly Lys 
    1190                 1195                 1200             


Gly Val  Val Gly Leu Phe Lys  Ser Gln Asn Ser Pro  Gln Ala Ala 
    1205                 1210                 1215             


Pro Thr  Ser Ser Leu Glu Ser  Ser Ser Ser Ile Glu  Gln Glu Lys 
    1220                 1225                 1230             


Tyr Leu  Gln Ala Leu Leu Asn  Ala Val Ser Val His  Gln Lys Leu 
    1235                 1240                 1245             


Arg Gly  Asn Ser Thr Leu Thr  Val Arg Pro Ala Phe  Ala Leu Ser 
    1250                 1255                 1260             


Pro Gly  Val Trp Ala Ser Leu  Arg Ser Ser Thr Arg  Leu Ile Ser 
    1265                 1270                 1275             


Ser Pro  Thr Ser Phe Ile Asp  Val Gly Ala Arg Leu  Ala Gly Lys 
    1280                 1285                 1290             


Asp His  Ser Ala Ser Phe Ser  Asn Ser Ser Tyr Leu  Gln Asn Gln 
    1295                 1300                 1305             


Leu Leu  Lys Arg Gln Ala Ala  Leu Tyr Ile Phe Gly  Glu Lys Ser 
    1310                 1315                 1320             


Gln Leu  Arg Asn Phe Lys Val  Glu Phe Ala Leu Asn  Cys Glu Phe 
    1325                 1330                 1335             


Val Pro  Val Glu Phe His Glu  Ile Arg Gln Val Lys  Ala Ser Phe 
    1340                 1345                 1350             


Lys Lys  Leu Met Arg Ala Cys  Ile Pro Ser Thr Ile  Pro Thr Asp 
    1355                 1360                 1365             


Ser Glu  Val Thr Phe Leu Lys  Ala Leu Gly Asp Ser  Glu Trp Phe 
    1370                 1375                 1380             


Pro Gln  Leu His Arg Ile Met  Gln Leu Ala Val Val  Val Ser Glu 
    1385                 1390                 1395             


Val Leu  Glu Asn Gly Ser Ser  Val Leu Val Cys Leu  Glu Glu Gly 
    1400                 1405                 1410             


Trp Asp  Ile Thr Ala Gln Val  Thr Ser Leu Val Gln  Leu Leu Ser 
    1415                 1420                 1425             


Asp Pro  Phe Tyr Arg Thr Leu  Glu Gly Phe Gln Met  Leu Val Glu 
    1430                 1435                 1440             


Lys Glu  Trp Leu Ser Phe Gly  His Lys Phe Ser Gln  Arg Ser Ser 
    1445                 1450                 1455             


Leu Thr  Leu Asn Cys Gln Gly  Ser Gly Phe Ala Pro  Val Phe Leu 
    1460                 1465                 1470             


Gln Phe  Leu Asp Cys Val His  Gln Val His Asn Gln  Tyr Pro Thr 
    1475                 1480                 1485             


Glu Phe  Glu Phe Asn Leu Tyr  Tyr Leu Lys Phe Leu  Ala Phe His 
    1490                 1495                 1500             


Tyr Val  Ser Asn Arg Phe Lys  Thr Phe Leu Leu Asp  Ser Asp Tyr 
    1505                 1510                 1515             


Glu Arg  Leu Glu His Gly Thr  Leu Phe Asp Asp Lys  Gly Glu Lys 
    1520                 1525                 1530             


His Ala  Lys Lys Gly Val Cys  Ile Trp Glu Cys Ile  Asp Arg Met 
    1535                 1540                 1545             


His Lys  Arg Ser Pro Ile Phe  Phe Asn Tyr Leu Tyr  Ser Pro Leu 
    1550                 1555                 1560             


Glu Ile  Glu Ala Leu Lys Pro  Asn Val Asn Val Ser  Ser Leu Lys 
    1565                 1570                 1575             


Lys Trp  Asp Tyr Tyr Ile Glu  Glu Thr Leu Ser Thr  Gly Pro Ser 
    1580                 1585                 1590             


Tyr Asp  Trp Met Met Leu Thr  Pro Lys His Phe Pro  Ser Glu Asp 
    1595                 1600                 1605             


Ser Asp  Leu Ala Gly Glu Ala  Gly Pro Arg Ser Gln  Arg Arg Thr 
    1610                 1615                 1620             


Val Trp  Pro Cys Tyr Asp Asp  Val Ser Cys Thr Gln  Pro Asp Ala 
    1625                 1630                 1635             


Leu Thr  Ser Leu Phe Ser Glu  Ile Glu Lys Leu Glu  His Lys Leu 
    1640                 1645                 1650             


Asn Gln  Ala Pro Glu Lys Trp  Gln Gln Leu Trp Glu  Arg Val Thr 
    1655                 1660                 1665             


Val Asp  Leu Lys Glu Glu Pro  Arg Thr Asp Arg Ser  Gln Arg His 
    1670                 1675                 1680             


Leu Ser  Arg Ser Pro Gly Ile  Val Ser Thr Asn Leu  Pro Ser Tyr 
    1685                 1690                 1695             


Gln Lys  Arg Ser Leu Leu His  Leu Pro Asp Ser Ser  Met Gly Glu 
    1700                 1705                 1710             


Glu Gln  Asn Ser Ser Ile Ser  Pro Ser Asn Gly Val  Glu Arg Arg 
    1715                 1720                 1725             


Ala Ala  Thr Leu Tyr Ser Gln  Tyr Thr Ser Lys Asn  Asp Glu Asn 
    1730                 1735                 1740             


Arg Ser  Phe Glu Gly Thr Leu  Tyr Lys Arg Gly Ala  Leu Leu Lys 
    1745                 1750                 1755             


Gly Trp  Lys Pro Arg Trp Phe  Val Leu Asp Val Thr  Lys His Gln 
    1760                 1765                 1770             


Leu Arg  Tyr Tyr Asp Ser Gly  Glu Asp Thr Ser Cys  Lys Gly His 
    1775                 1780                 1785             


Ile Asp  Leu Ala Glu Val Glu  Met Val Ile Pro Ala  Gly Pro Ser 
    1790                 1795                 1800             


Met Gly  Ala Pro Lys His Thr  Ser Asp Lys Ala Phe  Phe Asp Leu 
    1805                 1810                 1815             


Lys Thr  Ser Lys Arg Val Tyr  Asn Phe Cys Ala Gln  Asp Gly Gln 
    1820                 1825                 1830             


Ser Ala  Gln Gln Trp Met Asp  Lys Ile Gln Ser Cys  Ile Ser Asp 
    1835                 1840                 1845             


Ala 
    

<210>  408
<211>  1449
<212>  DNA
<213>  Homo sapiens

<400>  408
ctggatagaa cagctcaagc cttgccactt cgggcttctc actgcagctg ggcttggact     60

tcggagtttt gccattgcca gtgggacgtc tgagactttc tccttcaagt acttggcaga    120

tcactctctt agcagggtct gcgcttcgca gccgggatga agctggtttc cgtcgccctg    180

atgtacctgg gttcgctcgc cttcctaggc gctgacaccg ctcggttgga tgtcgcgtcg    240

gagtttcgaa agaagtggaa taagtgggct ctgagtcgtg ggaagaggga actgcggatg    300

tccagcagct accccaccgg gctcgctgac gtgaaggccg ggcctgccca gacccttatt    360

cggccccagg acatgaaggg tgcctctcga agccccgaag acagcagtcc ggatgccgcc    420

cgcatccgag tcaagcgcta ccgccagagc atgaacaact tccagggcct ccggagcttt    480

ggctgccgct tcgggacgtg cacggtgcag aagctggcac accagatcta ccagttcaca    540

gataaggaca aggacaacgt cgcccccagg agcaagatca gcccccaggg ctacggccgc    600

cggcgccggc gctccctgcc cgaggccggc ccgggtcgga ctctggtgtc ttctaagcca    660

caagcacacg gggctccagc ccccccgagt ggaagtgctc cccactttct ttaggattta    720

ggcgcccatg gtacaaggaa tagtcgcgca agcatcccgc tggtgcctcc cgggacgaag    780

gacttcccga gcggtgtggg gaccgggctc tgacagccct gcggagaccc tgagtccggg    840

aggcaccgtc cggcggcgag ctctggcttt gcaagggccc ctccttctgg gggcttcgct    900

tccttagcct tgctcaggtg caagtgcccc agggggcggg gtgcagaaga atccgagtgt    960

ttgccaggct taaggagagg agaaactgag aaatgaatgc tgagaccccc ggagcagggg   1020

tctgagccac agccgtgctc gcccacaaac tgatttctca cggcgtgtca ccccaccagg   1080

gcgcaagcct cactattact tgaactttcc aaaacctaaa gaggaaaagt gcaatgcgtg   1140

ttgtacatac agaggtaact atcaatattt aagtttgttg ctgtcaagat tttttttgta   1200

acttcaaata tagagatatt tttgtacgtt atatattgta ttaagggcat tttaaaagca   1260

attatattgt cctcccctat tttaagacgt gaatgtctca gcgaggtgta aagttgttcg   1320

ccgcgtggaa tgtgagtgtg tttgtgtgca tgaaagagaa agactgatta cctcctgtgt   1380

ggaagaagga aacaccgagt ctctgtataa tctatttaca taaaatgggt gatatgcgaa   1440

cagcaaacc                                                           1449


<210>  409
<211>  185
<212>  PRT
<213>  Homo sapiens

<400>  409


Met Lys Leu Val Ser Val Ala Leu Met Tyr Leu Gly Ser Leu Ala Phe 
1               5                   10                  15      


Leu Gly Ala Asp Thr Ala Arg Leu Asp Val Ala Ser Glu Phe Arg Lys 
            20                  25                  30          


Lys Trp Asn Lys Trp Ala Leu Ser Arg Gly Lys Arg Glu Leu Arg Met 
        35                  40                  45              


Ser Ser Ser Tyr Pro Thr Gly Leu Ala Asp Val Lys Ala Gly Pro Ala 
    50                  55                  60                  


Gln Thr Leu Ile Arg Pro Gln Asp Met Lys Gly Ala Ser Arg Ser Pro 
65                  70                  75                  80  


Glu Asp Ser Ser Pro Asp Ala Ala Arg Ile Arg Val Lys Arg Tyr Arg 
                85                  90                  95      


Gln Ser Met Asn Asn Phe Gln Gly Leu Arg Ser Phe Gly Cys Arg Phe 
            100                 105                 110         


Gly Thr Cys Thr Val Gln Lys Leu Ala His Gln Ile Tyr Gln Phe Thr 
        115                 120                 125             


Asp Lys Asp Lys Asp Asn Val Ala Pro Arg Ser Lys Ile Ser Pro Gln 
    130                 135                 140                 


Gly Tyr Gly Arg Arg Arg Arg Arg Ser Leu Pro Glu Ala Gly Pro Gly 
145                 150                 155                 160 


Arg Thr Leu Val Ser Ser Lys Pro Gln Ala His Gly Ala Pro Ala Pro 
                165                 170                 175     


Pro Ser Gly Ser Ala Pro His Phe Leu 
            180                 185 

<210>  410
<211>  583
<212>  DNA
<213>  Homo sapiens

<400>  410
cttttttcat ttttttcttc acttttctcc agccttcctc tctctctctc cttccttcct     60

ccttgctttc tttatatgcc ttatcttctg agaaggttga ccccagttcc ggcgatagac    120

ggacactaag ccccccttga gtgactagaa aggcagggga cataggaaca gttaggacat    180

aagggaagag taaagagagg gacccctgat tttgatttca gggtgccctg tttgtctcat    240

ccaatatcct gaagacccaa gatggagacc agctacttgt cccttccaaa aagcttccct    300

ggccttaatg tcagtgcttg taggtgatct cagaaacctc cctggtgaag aaaacctgaa    360

gacggggtct tgctctgttg cctggctgga gtgcagtggt gctaacatga ctcactgcac    420

ccttgacctc ctggactcaa gtgatcctcc cacctcagcc tcccaagtag ctgggactcc    480

aagtgggtgc cactacagcc aaaccttcag acctgtagat gggctcttct tggacattct    540

ggagtccctg ggggaaaggg aagtctgaag ctcagttggc cac                      583


<210>  411
<211>  86
<212>  PRT
<213>  Homo sapiens

<400>  411


Met Ser Val Leu Val Gly Asp Leu Arg Asn Leu Pro Gly Glu Glu Asn 
1               5                   10                  15      


Leu Lys Thr Gly Ser Cys Ser Val Ala Trp Leu Glu Cys Ser Gly Ala 
            20                  25                  30          


Asn Met Thr His Cys Thr Leu Asp Leu Leu Asp Ser Ser Asp Pro Pro 
        35                  40                  45              


Thr Ser Ala Ser Gln Val Ala Gly Thr Pro Ser Gly Cys His Tyr Ser 
    50                  55                  60                  


Gln Thr Phe Arg Pro Val Asp Gly Leu Phe Leu Asp Ile Leu Glu Ser 
65                  70                  75                  80  


Leu Gly Glu Arg Glu Val 
                85      

<210>  412
<211>  7840
<212>  DNA
<213>  Homo sapiens

<400>  412
aacgggaaac aagatggcgg ctgcaggtcc gagtactcgg gcctcttccg cggcggcagc     60

agccgctctg agtcggcggg gccggcgggg ccgctgtgac gagacggcgg cagctaagac    120

tggggcccca ggcccggctt ctggaccttc gctgttggtg ttgtcgccgc cgttgctgca    180

gccgccgctg ccgccgcggc cggaggaatc gggctgcgcc gggtgcctgg agccccccgg    240

agaagcagcg gccctgccgt gcggccactc gctttgccga ggctgcgccc aacgcgccgc    300

cgacgcggcg ggcccgggtt gccctcgctg ccgcgcccgc ggcccaggct gggcccgccg    360

tcgggcccgc gacgacggcc aggccgactc agaggtgctg ggcgagtgcg cccgccgcag    420

ccaacccgag cgctgccgcc cgcgccggga cgggggcgcg gctgccgcgg ggcccaggcc    480

agagcaggag ccgcgtgccg cgcctgcgga gccagacttt atattcagag caccaatcaa    540

attaagcaag cctggggaac ttcgtgagga atatgaaagc ttgagaaagc tgagagaaga    600

aaagttacaa gaggaaaaac cctctgaaga tcaaatccac aagctgttac cagaggatac    660

agaaacaggg aaaaggaaaa tggatgaaca gaaaaaaaga gatgaaccat tagtactgaa    720

aacaaatctg gaacgttgtc ctgcacgtct ctcagattca gagaatgaag aaccttctcg    780

aggccagatg acacagacac atcgctcggc atttgtttcc aagaacaact cctactcctt    840

agctttcctg gcagggaagc taaactccaa ggtggaaagg agtcagagct gtagtgacac    900

agcccaggaa agagcgaaga gcagagtcag agcagttcca ggcaacaaag ccaaggtcac    960

aactatgact ccagcctcca accccatcat tggtgtcctc ttgtcaactc aaaacaaccg   1020

ctgcgtctcg gcccctgact taaccatcga aaagcgtcta cccttcagct ccctttcatc   1080

cttggcttcc ctgcataagc cagagcgttc tgtcagccct gagagcaatg acagcatctc   1140

cgaagaacta aaccatttca agcccattgt ctgctcacca tgtactcctc ccaagagact   1200

ccctgatggc cgtgtgctaa gtcctctcat catcaaatca actccacgca acctaaacag   1260

aagcctgcag aagcagactt cttatgaggc cagtccacgg atcctcaaaa agtgggaaca   1320

gatctttcag gagcggcaga tcaaaaagac cctttcaaaa gccactctta cctctctggc   1380

tcctgaaatg ggggaagagt tactaggctc tgaaggtatc cattctagca aggagaagcc   1440

acttgtggct gtaaatacaa gattatctgg tgggcaggtc ctctctgagt atactggacc   1500

cacctctgct gatcttgatc atttcccctc tgttagccaa acaaaagcag aacaggacag   1560

tgataataaa agtagcactg agatcccact ggaaacctgc tgttcctcag aactcaaagg   1620

gggaggcagt gggacttctt tggagaggga gcagtttgag gggttagggt caactccaga   1680

tgccaagtta gacaaaacct gtataagcag agccatgaaa atcaccacag ttaattcagt   1740

gctaccccaa aacagtgttt tgggtggagt cctcaaaaca aagcaacaat tgaagacatt   1800

aaatcatttt gatctgacta atggtgttct agttgagagc ctaagtgaag agccacttcc   1860

ttctttgcgt cgaggccgga aaagacactg caagaccaag cacttagaac aaaatggctc   1920

ccttaaaaaa ctgcgacaaa ccagtgggga ggtgggtctg gccccaacag acccagtcct   1980

gcgagagatg gagcagaagc ttcagcaaga ggaagaagac cgacagttgg ctctgcagtt   2040

gcagcgcatg ttcgacaatg agaggcggac tgtgagccgg cgaaaaggaa gtgtggatca   2100

gtatctccta cggtccagca acatggccgg ggccaagtag cacctaatga agtgttacct   2160

atttttaaaa ggtcttaggc cttgatcatt tatcctgaag agctgagtgt tctcactttg   2220

gttttatttt aatggcaaaa cactgtctaa tatggttctg agaggttcca gggcctttgt   2280

agtcaatatc caagggaaaa gcatctccgt ttctctgtga cccaggccag aagcctgagt   2340

gacccatccc taagggcttc tgggccaaac ctggcagcac ccactgggaa tgagatttgg   2400

aacggcctca ggagcataat ggccacagtt agtaatggta aagaggggat accttcttaa   2460

actgatagac ttcctgactt ctttcagcag ggtattgttt taaatcagcc ttgcagataa   2520

aaattaattc catctttttc agacaagtga acaatttagt tccttggcag atccaaaatg   2580

atagatggtt atgttacgct ttctgctgtc ccttgccaaa aataagtaaa tatatcagtt   2640

aagattatgc ctttacaaaa gttaatttac attctctgtt taaaaaataa tatttggtga   2700

atgctatata gttgacagag cacatttaca gaccttatta atttagtctt tccaagagac   2760

ctctcatgta actggcatta gccccatttt tagatgatga aactgcagtg cagatgttct   2820

ggttctctca actaccaagt ggcataaccc atggattttc taaaggtttc ccaaatagat   2880

cacaacctaa gggtgtgcca ggggagccta ggggaagcta ggctgggcat tgaacactga   2940

tagtgcagaa tccacatgca aacaagatcg acagggtgga taaacatata tgtgcattat   3000

ccccatcccc cacagtttag agccttctgc ttttctgggg gtttcagcct atgagacaaa   3060

ctataatcag gcttcattat tacttttcaa atggccaagg gttatctgca atgttgatct   3120

aaaatcctaa aaaatcaccc tgaagtcagg caaggaacaa tacttaaact ccatactatg   3180

gaaacaaggt atctagctgg atgcagctgg taaattcagt cccatggacc tttgggggtt   3240

tattttcctt agcagctgac accatgtgtc ttttgcatcc ctggtggtgc ttggtgcttc   3300

tgcccatctg ggctcattga gaatagggat gaagatatga ttttagggaa tttctgatgg   3360

gctggcatgc cccatgtagt atgagttact atataaagtc atgtgactgg cattttaaca   3420

gaccttccag agcttatata tcccaatata tgttgtttcc tttgagtagc cccagcagga   3480

tactgcttag tttttccagt gccattggtg aaagcatttc tggaactgtc ttcaaagact   3540

agaaacactg actcccaaaa tgctagaact ggaagggacc ttaatggtta tctattccag   3600

cctcctccta aggtcctcct cagcttctag acctagaagc caaagtccag aacagtgacc   3660

cattgatcaa ggcagatagt ataactcctt ttaagtgttc tcagatttgc cttttctcag   3720

ggcaaatctt cagtgttttg tggttatttg tggttgagag agagagagaa tgtaatgtct   3780

gagactagcc agcagctatt tgaagcctct gggaaagaag gtggcttatc aagtgggttt   3840

gtagtaatga gtgctgctgt aaagcagagc cattttcttg tgcagctcat agttcccaaa   3900

cagttcccaa acagaaattc cagagatgtc ttaaacattg tggtcatcat tgagataggt   3960

ggaatctctt tggtgactac gttggtgggg aacatcactc acctgaatgt atgcattctg   4020

tgttctctgt gtgtgtgcac atatgcagat gtatgtttta aaaacattta ccaaactcat   4080

gattttgtag tcacaccact tcagttctgg gccctaccaa caatttatgt cctccaagag   4140

ctgctggagg gcatgtttgt gcccaaaaca gaagagctgg ctctggttta cagaagacag   4200

ggagggtgac cttactataa atgcccttag aggaaactta tcagttactg ccatttcacg   4260

catttccttt ttgatcttag taaatattat tggaaggcta gtcttgttgg taggagcaaa   4320

gacacttatt tttccacttg ccatctttct ctatatctcc agtaatttga aaaacacttt   4380

tcagttggaa ttgatttttg tctttggtaa aaagaaatat ttttaataga taaaagatat   4440

atattttaaa tatttcccca aattaatact ttcattttaa gaattgcata gcagttgtaa   4500

caagtgcaga atgaagaaca aattcttgtt aagcaaatag tccaaactct aggtccagct   4560

tactgccttc cccccttgta cctacagtga tgcctaggat ggtattgaca gttgttttct   4620

aaacttcctg ctgagcaaca gtccttcaaa tataggtaga gtggtctagg ttaaggaggg   4680

aggagggttg atctttaatc aggttggctt tggaggaagg aaaaaccact aaggtattat   4740

ctgaatttta agatgcttcc catccttaat aactaaaacc tgaatgcttt tctttctgaa   4800

aaatctccct ctctccttcc atgattctga agttggttaa aagtcgatat gttgatgtgt   4860

attatttggg ggaacagaaa aggacaagga aggaaacaga acgatgggaa gggtttgtga   4920

gctagaataa gaggtgcagg atttcacaaa acaaattcct cacaaatcat tgaagcccag   4980

ttcaccatac aaattaccca tgtcttactc tgttccttgt atatatgcat tctgggtttt   5040

tttattatta aaggggaagt taggggggag ggtgaaggtc agtctgaggg gaaatccagg   5100

aaatgtggtg cccttagaag ggggctgtca gctcttttcc atagagaggg aaagaaactt   5160

tgagaaaatg ttcttgaccc attgattgta tctgctggaa gaagtcatct gggcctgttg   5220

ggttggtatc agatcagggg attatgcatc cagcccctgg cccctttaat ctatttgcct   5280

ctttttaaaa aaggttaagt cttcttgggt gaggcttgcc agggaaactc ctaagtggct   5340

tcacttattt tttaaatttt aatttaattt ttaaattttt gcttggaagc agcactggta   5400

ataaatgttt tattttttgt tcattttccc taaaggaaaa atgtccttaa gagattaaag   5460

ctcttaattg attactgtct ggttacaaac tggcaaactg actaaaatgg gaagctgcca   5520

ccgtgcctga ctcatgtagc tgatgaccga aggctcatcc tttcttttct atttgacaga   5580

catttactga gcttcagact tgagccaacc ctgagctgga ctgtggagat aaagcagttc   5640

ctgctcttga ggagctcaat gtctaatgga atgcatttga atgtatgtgt ggctggagag   5700

ttcatttatg gtcttaggaa agccatttct ggtcccattt agaaaactga ccagcaccca   5760

gcaagctgca ttctacattt tagagacccc attggtattt gtgaatttga ttgcaccacc   5820

gcttttcctt tactaagtaa tgttatggaa ggagaatgaa ttttctcctc tagtgattac   5880

aggacattaa catctcttca gaagctgctt ttagcttaag ccccaagaag tgaggtgggt   5940

tgtggatcac tgacatggtc aggggaggcc cacacctcaa ttcagtaacc acctaatctc   6000

tcccccaacc tgatctctca tcagagctgg cagcaacttg ggattccttt cctttttcct   6060

gcctaacttt tcattgaaat gtctagtagg agagtgagaa aagagaacaa aggctgggtc   6120

acagtcatag aatgttacag ctggaatggg catggaaatc atccaagtta aacttcttct   6180

ctgccccccg cccccacttt tttttttttt tttttttaac caaacgaact tgtgatccag   6240

tgccctattt tatagtgtgg ttttccaggg tctgaataaa taatcattaa agtttgacac   6300

acgcagacac acgcaccaat gatggggata cccccaaatg atttaggagg ttattttatt   6360

ttaatagttt tttcttcctg atttttttca gttagttaga gttaaatgta cctatagccc   6420

ctgaatacat gctcaggtag agaaagtctc catagtataa gtaagtaata tgaatgtgga   6480

atcttggaaa gtgatatatt ttgattggaa taattttaat taaatttaat gattttaatt   6540

aagaattaaa agccagctag ccaaattttc tttaaaaatt ggaaactcat tatggtctta   6600

aattgtcctc aggcagcctt ttcctcatca acccatagag tggtcttttg aactggtatc   6660

taaacatacc tggttatgaa ttctcaaaag agaaagcagg tctggggcgg ggtggtcagg   6720

agacagattc tagggaaagt gctgaagaga ttttcttctg aagatgatct aggaaatgca   6780

tctttataca tgattgttag ctgctgtagc tttctgaaga agattgtaga aaagagacta   6840

agatatatgc aagggtcacc agtttagaga tcagtcaaat tggaaaaagt gccaagactg   6900

gatgtgcaga ttgttctatg tattatcagt atttttttcc tcttaagaaa aaaatttact   6960

ctctctcctt tgtgagtaaa tgcctcctta atgcctttta agtaaggtgg caacttttaa   7020

ctgtcatctt gtgagaggca acctcaaact ctaagcagac tccctctctc cctttctggt   7080

gtcttaaatc aagaactagt ttgaagccaa ggcaaagcaa ggtttgttca tcttcctttc   7140

ctgtcattta aggtaaaaca ggcaatgaac tcgctcttca aataccatag ttcaagagta   7200

gctgttggcc ctggttccag attaatatag cagcaggcag attgcccctt cttggggcca   7260

ccaccctcca aagctgtgcc accaatgaga gcattgggtt caagtttgca tcaaacatgg   7320

tattaccaac gctgagcctc cagcagagca cttaaaagtc ctagtgagag aatagatact   7380

atgcaaggga aaaaaattta aatgccaacg aatagttttt ttttttttga acctgataca   7440

ctgtttgttt actctcaact ctttgtacaa atattattgt cctaagggcc ttttcccctc   7500

ctgcctagaa aataggttgt gtattggttt tattcaacct gctgtctgct ttaggattgg   7560

agaaggtacc tggatccttg tggactgcca ctgctggctg cctcctctcc aactcatcag   7620

aagagcattt tgacaaagac agaggacttg gaccagggca tgccctgttg gggatgtttc   7680

tgtcagcaag gacatggcat ggaatcaagt gggctgatgt gttgttattt aaacagtacc   7740

aaagtgcatt cttcaatgta tgtttgcctg cttgaagcaa ggcccaagtt gagaatacag   7800

taaaggaaac tcatgaaagt ggaaaaaaaa aaaaaaaaaa                         7840


<210>  413
<211>  708
<212>  PRT
<213>  Homo sapiens

<400>  413


Met Ala Ala Ala Gly Pro Ser Thr Arg Ala Ser Ser Ala Ala Ala Ala 
1               5                   10                  15      


Ala Ala Leu Ser Arg Arg Gly Arg Arg Gly Arg Cys Asp Glu Thr Ala 
            20                  25                  30          


Ala Ala Lys Thr Gly Ala Pro Gly Pro Ala Ser Gly Pro Ser Leu Leu 
        35                  40                  45              


Val Leu Ser Pro Pro Leu Leu Gln Pro Pro Leu Pro Pro Arg Pro Glu 
    50                  55                  60                  


Glu Ser Gly Cys Ala Gly Cys Leu Glu Pro Pro Gly Glu Ala Ala Ala 
65                  70                  75                  80  


Leu Pro Cys Gly His Ser Leu Cys Arg Gly Cys Ala Gln Arg Ala Ala 
                85                  90                  95      


Asp Ala Ala Gly Pro Gly Cys Pro Arg Cys Arg Ala Arg Gly Pro Gly 
            100                 105                 110         


Trp Ala Arg Arg Arg Ala Arg Asp Asp Gly Gln Ala Asp Ser Glu Val 
        115                 120                 125             


Leu Gly Glu Cys Ala Arg Arg Ser Gln Pro Glu Arg Cys Arg Pro Arg 
    130                 135                 140                 


Arg Asp Gly Gly Ala Ala Ala Ala Gly Pro Arg Pro Glu Gln Glu Pro 
145                 150                 155                 160 


Arg Ala Ala Pro Ala Glu Pro Asp Phe Ile Phe Arg Ala Pro Ile Lys 
                165                 170                 175     


Leu Ser Lys Pro Gly Glu Leu Arg Glu Glu Tyr Glu Ser Leu Arg Lys 
            180                 185                 190         


Leu Arg Glu Glu Lys Leu Gln Glu Glu Lys Pro Ser Glu Asp Gln Ile 
        195                 200                 205             


His Lys Leu Leu Pro Glu Asp Thr Glu Thr Gly Lys Arg Lys Met Asp 
    210                 215                 220                 


Glu Gln Lys Lys Arg Asp Glu Pro Leu Val Leu Lys Thr Asn Leu Glu 
225                 230                 235                 240 


Arg Cys Pro Ala Arg Leu Ser Asp Ser Glu Asn Glu Glu Pro Ser Arg 
                245                 250                 255     


Gly Gln Met Thr Gln Thr His Arg Ser Ala Phe Val Ser Lys Asn Asn 
            260                 265                 270         


Ser Tyr Ser Leu Ala Phe Leu Ala Gly Lys Leu Asn Ser Lys Val Glu 
        275                 280                 285             


Arg Ser Gln Ser Cys Ser Asp Thr Ala Gln Glu Arg Ala Lys Ser Arg 
    290                 295                 300                 


Val Arg Ala Val Pro Gly Asn Lys Ala Lys Val Thr Thr Met Thr Pro 
305                 310                 315                 320 


Ala Ser Asn Pro Ile Ile Gly Val Leu Leu Ser Thr Gln Asn Asn Arg 
                325                 330                 335     


Cys Val Ser Ala Pro Asp Leu Thr Ile Glu Lys Arg Leu Pro Phe Ser 
            340                 345                 350         


Ser Leu Ser Ser Leu Ala Ser Leu His Lys Pro Glu Arg Ser Val Ser 
        355                 360                 365             


Pro Glu Ser Asn Asp Ser Ile Ser Glu Glu Leu Asn His Phe Lys Pro 
    370                 375                 380                 


Ile Val Cys Ser Pro Cys Thr Pro Pro Lys Arg Leu Pro Asp Gly Arg 
385                 390                 395                 400 


Val Leu Ser Pro Leu Ile Ile Lys Ser Thr Pro Arg Asn Leu Asn Arg 
                405                 410                 415     


Ser Leu Gln Lys Gln Thr Ser Tyr Glu Ala Ser Pro Arg Ile Leu Lys 
            420                 425                 430         


Lys Trp Glu Gln Ile Phe Gln Glu Arg Gln Ile Lys Lys Thr Leu Ser 
        435                 440                 445             


Lys Ala Thr Leu Thr Ser Leu Ala Pro Glu Met Gly Glu Glu Leu Leu 
    450                 455                 460                 


Gly Ser Glu Gly Ile His Ser Ser Lys Glu Lys Pro Leu Val Ala Val 
465                 470                 475                 480 


Asn Thr Arg Leu Ser Gly Gly Gln Val Leu Ser Glu Tyr Thr Gly Pro 
                485                 490                 495     


Thr Ser Ala Asp Leu Asp His Phe Pro Ser Val Ser Gln Thr Lys Ala 
            500                 505                 510         


Glu Gln Asp Ser Asp Asn Lys Ser Ser Thr Glu Ile Pro Leu Glu Thr 
        515                 520                 525             


Cys Cys Ser Ser Glu Leu Lys Gly Gly Gly Ser Gly Thr Ser Leu Glu 
    530                 535                 540                 


Arg Glu Gln Phe Glu Gly Leu Gly Ser Thr Pro Asp Ala Lys Leu Asp 
545                 550                 555                 560 


Lys Thr Cys Ile Ser Arg Ala Met Lys Ile Thr Thr Val Asn Ser Val 
                565                 570                 575     


Leu Pro Gln Asn Ser Val Leu Gly Gly Val Leu Lys Thr Lys Gln Gln 
            580                 585                 590         


Leu Lys Thr Leu Asn His Phe Asp Leu Thr Asn Gly Val Leu Val Glu 
        595                 600                 605             


Ser Leu Ser Glu Glu Pro Leu Pro Ser Leu Arg Arg Gly Arg Lys Arg 
    610                 615                 620                 


His Cys Lys Thr Lys His Leu Glu Gln Asn Gly Ser Leu Lys Lys Leu 
625                 630                 635                 640 


Arg Gln Thr Ser Gly Glu Val Gly Leu Ala Pro Thr Asp Pro Val Leu 
                645                 650                 655     


Arg Glu Met Glu Gln Lys Leu Gln Gln Glu Glu Glu Asp Arg Gln Leu 
            660                 665                 670         


Ala Leu Gln Leu Gln Arg Met Phe Asp Asn Glu Arg Arg Thr Val Ser 
        675                 680                 685             


Arg Arg Lys Gly Ser Val Asp Gln Tyr Leu Leu Arg Ser Ser Asn Met 
    690                 695                 700                 


Ala Gly Ala Lys 
705             

<210>  414
<211>  5028
<212>  DNA
<213>  Homo sapiens

<400>  414
agtttgggtc ttgctggcgc gaggtagtca gaggacgtgg ccgcggggct tgctgggact     60

tgaggttaga cgtcccggcc gtcggttgcc gcctacactg tctgccgtcg cgtcgcagtt    120

actaaggcgt ggggaagata gcggcaggca ccgcagtgga gcggctccga gatccccggg    180

gggctcgcag gcgcgcatcc ctcctgactg ggacgtcgcc tccgcagacc cctcggaggc    240

tgaagcgacg ccggaggcag gcaaagaaac aagtgaagaa acaaaaaaaa aaggaagtta    300

aggggccatt cccaaagtca aagatcaagg agatggcctt ctcaggaatc tacaagctgg    360

atgatgggaa gccttacctg aacaactgct tcccagccag aaatctgctt cgcgtgccgg    420

aggaaggcca aggacactgg ttagtggttc agaaaggtaa cctcaagaag aagcccaagg    480

gtttggttgg agcacaagct gaacgtcggg aaagcctgaa ggcgacttct tttgagttca    540

aggggaagaa agagtctcgg cgggaaaatc aggtggacct tcctggacat atcctggacc    600

aggcttttct gctgaagcac cactgtgtga ggaagccatc agatctgtgc accattaatg    660

ccaaggaaaa tgacttcaag cattttcatt ctgtgattta tatcaatgcc tcagaaaacc    720

tgctgcctct agaggcattt cacacgtttc cagccctaaa ggaactggat ctcgcattta    780

atggcatcaa aactatctac gtgaaatatg gagactttaa gttattagaa ttcttggacc    840

tttccttcaa cagcctgact gtggaggcca tctgtgattt ggggattctg ccacacctcc    900

gtgtcctgct cctcacaggc aatggcctta cctccctgcc gcccaatttg gccgtcgcag    960

aacaggaggc atctgtaaca tcgctgacaa gcaagaggta catcctgagg ttcccagcgc   1020

tggagacact gatgctggat gacaacagac tctccaaccc cagttgcttt gccagcctgg   1080

ctgggctcag gagactgaag aagttaagct tggatgaaaa caggattatc aggatcccat   1140

acctacagca agttcagctc tatgacgagt cagtagactg gaatggaggc aggggaagtc   1200

cccataaaga gccccaattc atgctgcagt ccaagccaag gatgcttgag gactcagatg   1260

agcaactgga ttatactgta ctgcccatga aaaaggatgt tgaccggaca gaggttgtgt   1320

tttcatctta ccctggattt tcaacctcag agacaaccaa gatatgttca cttcctccca   1380

tattcgagat ccttcctgtg aagtcactga aggccaggaa ccagacgctg gccccaccct   1440

tcccagagct gagatacctt agcctggcct acaacaagat cgcaaaagag gatgctgtcc   1500

taccagtagc tctcttccca tctctctgcg agttcgtctt tcataacaac cctctggtgg   1560

cccatacacg aggggtccct ccactgctga agagcttcct ccaggagcga ctgggaatcc   1620

acttaattcg aaggaagata gtaaagccta agcatcatgt tttgatgtct cggaaggaat   1680

catggaaggt gaaaagcgaa atcccaaagg tgccgaagca gcctctggtg ctccatcacc   1740

cgcgcatgac gacaaccaag tctccctcaa aggatatgct agagccagag gcagagctgg   1800

ctgaagatct gcccactacc aaaagcactt ctgtggagtc agagatgccc actgagaacc   1860

tggaaggcca ttccccgtct tgccggacct tcgtgccact gcctcccatc tgctccaact   1920

ccactgtgca tagtgaagag accctgtccc acctgagtga cacaactgtc cgcctcagcc   1980

cagagcgccc atcagatgag gactccaaga gcacagagtc catcttcctg acccaggtga   2040

gtgaactgcc ttcctccgtc atccataagg atgatttaga gttaaaggag aaagaccaaa   2100

agaaaccacc aacggcaccc agagaggtga aagggactcg gaggaaactc ccaactgcct   2160

tccttcccag caagtaccac ggctatgaag aactgctgac agccaagcct gatccagcct   2220

tcattgagcc aaagggaatc cagaagaatg cacaagccct gcaacaaatg ctgaagcacc   2280

cactcctgtg ccactcctcc aagcccaagc tggacactct tcagaaaccc tatgttcaca   2340

aagagaaacg ggcccagaga atcccgattc cacccccaaa gaagactaga gcccaacttc   2400

tggatgacat cttcattcgc ttgcgggatc cccggaacat tacagaggct ccactaggtg   2460

ctgtcctgca ccagtggaca gaacggcggc tggtgaacca caagcagtac ctggaggcca   2520

agaggctgtt gaaggagttc caggcacgtt accggcagct ggtgagtggc tctctgcgca   2580

cagtgttcgg gactaccccg ctccccatgg cctgcccagc gctgagtgag agccagccca   2640

agttcggcca cttcctcgag ttcatggatg agttctgcca ggagcccaca gccagtgact   2700

cacaaggcta gagctgtgca tgggggctgt gtgcaccacc cggcctgtgc cccagctctc   2760

cccgagggct ctgtgccctg gaccgcacct caaggttgac cagccggcca caggcctcag   2820

agctcagctg ggccccactt gctggccaca aggtggcatc cccttgtcag gatctcccct   2880

ccttggccca ggcatgacct ggtgcctggc ccagcggcaa taaagagtgg gtgcacaggg   2940

caatagactg ggtgccacat gcattctttc ttggaaccca ggccacagca gcattgtcac   3000

acttccctct aaaaatggtt ttccagttca gatgcaacag ggatacattt gttctctgtt   3060

gtatgagaaa ctgacaccaa ggggatctta acaaattcct gaacaatggc tccaaaaaag   3120

ggtattttta aaaaccagat cttgtgagta cagccctaat gtgcagggac agtgtcatcc   3180

tgtatattcg ttctttactc agactctttc ttggttcctt cattaggagc atgaatggtt   3240

gaatgtgaac atgacagtaa attggagcaa actgtaaact ggacataact tatgccaaaa   3300

gacgtagttg tacaccatgg aaaccccatc cctgctccta atctctactg ccattctgaa   3360

tgccaaagca agacatccaa catggggcat ctcccagagc acatacagca ccaaaaatcc   3420

acacacagcc taagcttaac ccatgttttt gtctgagatt gttcaccaga gacaagactc   3480

tgactataaa cagaacatcc actttcatga gtttccttta ctgtattctc aacttgggcc   3540

ttgcttcaag caggcaaaca tacattgaag aatgcacttt ggtactgttt aaataacaac   3600

acatcagccc acttgattcc atgccatgtc cttgctgaca gaaacatccc caacagggca   3660

tgccctggtc caagtcctct gtctttgtca aaatgctctt ctgatgagtt ggagaggagg   3720

cagccagcag tggcagtcca caaggatcca ggtaccttct ccaatcctaa agcagacagc   3780

aggttgaata aaaccaatac acaacctatt ttctaggcag gaggggaaaa ggcccttagg   3840

acaataatat ttgtacaaag agttgagagt aaacaaacag tgtatcaggt tcaaaaaaaa   3900

aaaaactatt cgttggcatt taaatttttt tcccttgcat agtatctatt ctctcactag   3960

gacttttaag tgctctgctg gaggctcagc gttggtaata ccatgtttga tgcaaacttg   4020

aacccaatgc tctcattggt ggcacagctt tggagggtgg tggccccaag aaggggcaat   4080

ctgcctgctg ctatattaat ctggaaccag ggccaacagc tactcttgaa ctatggtatt   4140

tgaagagcga gttcattgcc tgttttacct taaatgacag gaaaggaaga tgaacaaacc   4200

ttgctttgcc ttggcttcaa actagttctt gatttaagac accagaaagg gagagaggga   4260

gtctgcttag agtttgaggt tgcctctcac aagatgacag ttaaaagttg ccaccttact   4320

taaaaggcat taaggaggca tttactcaca aaggagagag agtaaatttt tttcttaaga   4380

ggaaaaaaat actgataata catagaacaa tctgcacatc cagtcttggc actttttcca   4440

atttgactga tctctaaact ggtgaccctt gcatatatct tagtctcttt tctacaatct   4500

tcttcagaaa gctacagcag ctaacaatca tgtataaaga tgcatttcct agatcatctt   4560

cagaagaaaa tctcttcagc actttcccta gaatctgtct cctgaccacc ccgccccaga   4620

cctgctttct cttttgagaa ttcataacca ggtatgttta gataccagtt caaaagacca   4680

ctctatgggt tgatgaggaa aaggctgcct gaggacaatt taagaccata atgagtttcc   4740

aatttttaaa gaaaatttgg ctagctggct tttaattctt aattaaaatc attaaattta   4800

attaaaatta ttccaatcaa aatatatcac tttccaagat tccacattca tattacttac   4860

ttatactatg gagactttct ctacctgagc atgtattcag gggctatagg tacatttaac   4920

tctaactaac tgaaaaaaat caggaagaaa aaactattaa aataaaataa cctcctaaat   4980

catttggggg tatccccatc aaaaaaaaaa ataaaaaaaa aaaaaaaa                5028


<210>  415
<211>  792
<212>  PRT
<213>  Homo sapiens

<400>  415


Met Ala Phe Ser Gly Ile Tyr Lys Leu Asp Asp Gly Lys Pro Tyr Leu 
1               5                   10                  15      


Asn Asn Cys Phe Pro Ala Arg Asn Leu Leu Arg Val Pro Glu Glu Gly 
            20                  25                  30          


Gln Gly His Trp Leu Val Val Gln Lys Gly Asn Leu Lys Lys Lys Pro 
        35                  40                  45              


Lys Gly Leu Val Gly Ala Gln Ala Glu Arg Arg Glu Ser Leu Lys Ala 
    50                  55                  60                  


Thr Ser Phe Glu Phe Lys Gly Lys Lys Glu Ser Arg Arg Glu Asn Gln 
65                  70                  75                  80  


Val Asp Leu Pro Gly His Ile Leu Asp Gln Ala Phe Leu Leu Lys His 
                85                  90                  95      


His Cys Val Arg Lys Pro Ser Asp Leu Cys Thr Ile Asn Ala Lys Glu 
            100                 105                 110         


Asn Asp Phe Lys His Phe His Ser Val Ile Tyr Ile Asn Ala Ser Glu 
        115                 120                 125             


Asn Leu Leu Pro Leu Glu Ala Phe His Thr Phe Pro Ala Leu Lys Glu 
    130                 135                 140                 


Leu Asp Leu Ala Phe Asn Gly Ile Lys Thr Ile Tyr Val Lys Tyr Gly 
145                 150                 155                 160 


Asp Phe Lys Leu Leu Glu Phe Leu Asp Leu Ser Phe Asn Ser Leu Thr 
                165                 170                 175     


Val Glu Ala Ile Cys Asp Leu Gly Ile Leu Pro His Leu Arg Val Leu 
            180                 185                 190         


Leu Leu Thr Gly Asn Gly Leu Thr Ser Leu Pro Pro Asn Leu Ala Val 
        195                 200                 205             


Ala Glu Gln Glu Ala Ser Val Thr Ser Leu Thr Ser Lys Arg Tyr Ile 
    210                 215                 220                 


Leu Arg Phe Pro Ala Leu Glu Thr Leu Met Leu Asp Asp Asn Arg Leu 
225                 230                 235                 240 


Ser Asn Pro Ser Cys Phe Ala Ser Leu Ala Gly Leu Arg Arg Leu Lys 
                245                 250                 255     


Lys Leu Ser Leu Asp Glu Asn Arg Ile Ile Arg Ile Pro Tyr Leu Gln 
            260                 265                 270         


Gln Val Gln Leu Tyr Asp Glu Ser Val Asp Trp Asn Gly Gly Arg Gly 
        275                 280                 285             


Ser Pro His Lys Glu Pro Gln Phe Met Leu Gln Ser Lys Pro Arg Met 
    290                 295                 300                 


Leu Glu Asp Ser Asp Glu Gln Leu Asp Tyr Thr Val Leu Pro Met Lys 
305                 310                 315                 320 


Lys Asp Val Asp Arg Thr Glu Val Val Phe Ser Ser Tyr Pro Gly Phe 
                325                 330                 335     


Ser Thr Ser Glu Thr Thr Lys Ile Cys Ser Leu Pro Pro Ile Phe Glu 
            340                 345                 350         


Ile Leu Pro Val Lys Ser Leu Lys Ala Arg Asn Gln Thr Leu Ala Pro 
        355                 360                 365             


Pro Phe Pro Glu Leu Arg Tyr Leu Ser Leu Ala Tyr Asn Lys Ile Ala 
    370                 375                 380                 


Lys Glu Asp Ala Val Leu Pro Val Ala Leu Phe Pro Ser Leu Cys Glu 
385                 390                 395                 400 


Phe Val Phe His Asn Asn Pro Leu Val Ala His Thr Arg Gly Val Pro 
                405                 410                 415     


Pro Leu Leu Lys Ser Phe Leu Gln Glu Arg Leu Gly Ile His Leu Ile 
            420                 425                 430         


Arg Arg Lys Ile Val Lys Pro Lys His His Val Leu Met Ser Arg Lys 
        435                 440                 445             


Glu Ser Trp Lys Val Lys Ser Glu Ile Pro Lys Val Pro Lys Gln Pro 
    450                 455                 460                 


Leu Val Leu His His Pro Arg Met Thr Thr Thr Lys Ser Pro Ser Lys 
465                 470                 475                 480 


Asp Met Leu Glu Pro Glu Ala Glu Leu Ala Glu Asp Leu Pro Thr Thr 
                485                 490                 495     


Lys Ser Thr Ser Val Glu Ser Glu Met Pro Thr Glu Asn Leu Glu Gly 
            500                 505                 510         


His Ser Pro Ser Cys Arg Thr Phe Val Pro Leu Pro Pro Ile Cys Ser 
        515                 520                 525             


Asn Ser Thr Val His Ser Glu Glu Thr Leu Ser His Leu Ser Asp Thr 
    530                 535                 540                 


Thr Val Arg Leu Ser Pro Glu Arg Pro Ser Asp Glu Asp Ser Lys Ser 
545                 550                 555                 560 


Thr Glu Ser Ile Phe Leu Thr Gln Val Ser Glu Leu Pro Ser Ser Val 
                565                 570                 575     


Ile His Lys Asp Asp Leu Glu Leu Lys Glu Lys Asp Gln Lys Lys Pro 
            580                 585                 590         


Pro Thr Ala Pro Arg Glu Val Lys Gly Thr Arg Arg Lys Leu Pro Thr 
        595                 600                 605             


Ala Phe Leu Pro Ser Lys Tyr His Gly Tyr Glu Glu Leu Leu Thr Ala 
    610                 615                 620                 


Lys Pro Asp Pro Ala Phe Ile Glu Pro Lys Gly Ile Gln Lys Asn Ala 
625                 630                 635                 640 


Gln Ala Leu Gln Gln Met Leu Lys His Pro Leu Leu Cys His Ser Ser 
                645                 650                 655     


Lys Pro Lys Leu Asp Thr Leu Gln Lys Pro Tyr Val His Lys Glu Lys 
            660                 665                 670         


Arg Ala Gln Arg Ile Pro Ile Pro Pro Pro Lys Lys Thr Arg Ala Gln 
        675                 680                 685             


Leu Leu Asp Asp Ile Phe Ile Arg Leu Arg Asp Pro Arg Asn Ile Thr 
    690                 695                 700                 


Glu Ala Pro Leu Gly Ala Val Leu His Gln Trp Thr Glu Arg Arg Leu 
705                 710                 715                 720 


Val Asn His Lys Gln Tyr Leu Glu Ala Lys Arg Leu Leu Lys Glu Phe 
                725                 730                 735     


Gln Ala Arg Tyr Arg Gln Leu Val Ser Gly Ser Leu Arg Thr Val Phe 
            740                 745                 750         


Gly Thr Thr Pro Leu Pro Met Ala Cys Pro Ala Leu Ser Glu Ser Gln 
        755                 760                 765             


Pro Lys Phe Gly His Phe Leu Glu Phe Met Asp Glu Phe Cys Gln Glu 
    770                 775                 780                 


Pro Thr Ala Ser Asp Ser Gln Gly 
785                 790         

<210>  416
<211>  2731
<212>  DNA
<213>  Homo sapiens

<400>  416
agacaagtcg gaggggaggg agacgcagag gcggacaaga tggcggcggc agctgtacag     60

ggcgggagaa gcggtggtag cggaggctgt agtggggctg gtggtgcttc caactgcggg    120

acaggaagtg gccgtagcgg cttgttggat aagtggaaga tagatgataa gcctgtaaaa    180

attgacaagt gggatggatc agctgtgaaa aactctttgg atgattctgc caaaaaggta    240

cttctggaaa aatacaaata tgtggagaat tttggtctaa ttgatggtcg cctcaccatc    300

tgtacaatct cctgtttctt tgccatagtg gctttgattt gggattatat gcaccccttt    360

ccagagtcca aacccgtttt ggctttgtgt gtcatatcct attttgtgat gatggggatt    420

ctgaccattt atacctcata taaggagaag agcatctttc tcgtggccca caggaaagat    480

cctacaggaa tggatcctga tgatatttgg cagctgtcct ccagtcttaa aaggtttgat    540

gacaaataca ccttgaagct gaccttcatc agtgggagaa caaagcagca gcgggaagcc    600

gagttcacaa agtccattgc taagtttttt gaccacagtg ggacactggt catggatgca    660

tatgagcctg aaatatccag gctccatgac agtcttgcca tagaaagaaa aataaagtag    720

ccaattctaa aagtagccct ctttctcctg gatcttgctg aattagtggc ttggggggtg    780

ggggagataa aaagaactta aaatgggtaa agtaagaaat gttaaaaagt ccctgttttg    840

tcctgaaatt ttagtctatt ctgggtaaat aggattttct gacacagata tgagaagttg    900

tagctctgat gtctagctgt agtctccttg atctgctgat tgcattattt taatttgctt    960

ttctgggaaa gcagttttgc taaaagctgt acagactttt tcttttgtac ctagcagtac   1020

tttatatagt atagctttgg gccatgtagc attttaagac tcaattttaa aaaattatta   1080

atctgttgct gactcttaat tcctatttca atatgtgttt ccttgaagaa ttcaggatac   1140

aacttcttgt gtatgacagc tttccttcac acactatttt tgtgggtgtg tatatatctg   1200

atttgggaag aatttaaaaa acacatagct ttttaatttg tttgaaacag actttctgcc   1260

tgttacattt ttgcttttaa ccaattaaag aagccaatgg cattttagtt ttatattgtg   1320

ttttccacta gtatatccct gttgatttgt ttgtgccttt tattaactgc cattttctaa   1380

aatttttttc aataaaagga aggaagatgt gaaaaaaatg gagtcatagt tttgatggag   1440

agaacagaga aacaagtgtt aacatctttc tactataggt ttttttcatt tttaggctat   1500

tttacttgtc aaaggcccct gagaacctgt agctaaggaa ctcttagctt tccagtgata   1560

ataacaataa taacaacatt ctgtacttac tttgtgccag aaatgctcca agtactttac   1620

atgtgttaat aatgctcaca gcaatcctaa gaggcaggtg ctgttattat ccccatttta   1680

cacatgagga aactgagata caaaagttaa ataattgtca cacagctagt gatagaactg   1740

ggattcaaac ctggggagtc cggcttcaga gtttgtggtc ctgcagagac aaaacagccg   1800

cttttccagt attttcccag tatggtcaga gaagacctgg gtgcttgcca agatcctttg   1860

acctttagga atatttccct acagccttac aaaacatcaa ttttggctga gcctagtacc   1920

caacactata ttcagtttgt aagaaattac cattatcaca tttcctgttt gtcttggaga   1980

ggttgtccta tctcgcacca catggtaggg aattgtgaac aacactggac agaaagttaa   2040

agccttggat tctgtactct tcattcctgt aaaccttggg taagtttcgg aattctctgt   2100

gagcttctta aagtttttga aagcatgtaa ccggataagt gtatttttac aatggaggag   2160

ttacagtcat cttggtattt gtgggagatt ggttccagga tccccaagca taccaaaatc   2220

caaggatgct caagtccctt atataaaatg gtatagcatt tgcatataac ctacacacat   2280

cctcccatat acttttaatc acctctggat tacctataat acctaatata atgtaaatgc   2340

tatgtaaata gttatactgc attggttttt taatttatat tttttgttat tttttaaaat   2400

atatttttaa tccatggttg gttaaatctg tagatataga gggccaactg tactgttaga   2460

cacaagggtc tcgaggcttg cagatagaga ctgaataacc ctctccatga tgatccctta   2520

gagttccccc actgtgcctt tttctttaca tgtgcatgca aacatgtgtc tccacataca   2580

ttttttttaa caaaaattga attatgttga tatatgtcct gtaatttgtg ttttaaactt   2640

aatatatctt aggcattttc cctgtgtgtg tgtataatgc agctattaaa aatgagtctg   2700

aggccaggaa aaaaaaaaaa aaaaaaaaaa a                                  2731


<210>  417
<211>  226
<212>  PRT
<213>  Homo sapiens

<400>  417


Met Ala Ala Ala Ala Val Gln Gly Gly Arg Ser Gly Gly Ser Gly Gly 
1               5                   10                  15      


Cys Ser Gly Ala Gly Gly Ala Ser Asn Cys Gly Thr Gly Ser Gly Arg 
            20                  25                  30          


Ser Gly Leu Leu Asp Lys Trp Lys Ile Asp Asp Lys Pro Val Lys Ile 
        35                  40                  45              


Asp Lys Trp Asp Gly Ser Ala Val Lys Asn Ser Leu Asp Asp Ser Ala 
    50                  55                  60                  


Lys Lys Val Leu Leu Glu Lys Tyr Lys Tyr Val Glu Asn Phe Gly Leu 
65                  70                  75                  80  


Ile Asp Gly Arg Leu Thr Ile Cys Thr Ile Ser Cys Phe Phe Ala Ile 
                85                  90                  95      


Val Ala Leu Ile Trp Asp Tyr Met His Pro Phe Pro Glu Ser Lys Pro 
            100                 105                 110         


Val Leu Ala Leu Cys Val Ile Ser Tyr Phe Val Met Met Gly Ile Leu 
        115                 120                 125             


Thr Ile Tyr Thr Ser Tyr Lys Glu Lys Ser Ile Phe Leu Val Ala His 
    130                 135                 140                 


Arg Lys Asp Pro Thr Gly Met Asp Pro Asp Asp Ile Trp Gln Leu Ser 
145                 150                 155                 160 


Ser Ser Leu Lys Arg Phe Asp Asp Lys Tyr Thr Leu Lys Leu Thr Phe 
                165                 170                 175     


Ile Ser Gly Arg Thr Lys Gln Gln Arg Glu Ala Glu Phe Thr Lys Ser 
            180                 185                 190         


Ile Ala Lys Phe Phe Asp His Ser Gly Thr Leu Val Met Asp Ala Tyr 
        195                 200                 205             


Glu Pro Glu Ile Ser Arg Leu His Asp Ser Leu Ala Ile Glu Arg Lys 
    210                 215                 220                 


Ile Lys 
225     

<210>  418
<211>  2748
<212>  DNA
<213>  Homo sapiens

<400>  418
cttttcgttg ccgttacctg tttccggcag tcgacacgct cttcgcttct cggggcttgt     60

ctccgtgtcc tccgtctcag ttgtttctcc ctctctatcc tcctctgtct cagtctcccc    120

agccttgggg ccggtgcctc ttccgggctt cggcgaatga gacctgcgga cctgcccccg    180

cgccccatgg aagaatcccc ggcgtccagc tctgccccga cagagacgga ggagccgggg    240

tccagtgcag aggtcatgga agaagtgaca acatgctcct tcaacagccc tctgttccgg    300

caggaagatg acagagggat tacctaccgg atcccagccc tgctctacat accccccacc    360

cacaccttcc tggcctttgc agagaagcgt tctacgagga gagatgagga tgctctccac    420

ctggtgctga ggcgagggtt gaggattggg cagttggtac agtgggggcc cctgaagcca    480

ctgatggaag ccacactacc ggggcatcgg accatgaacc cctgtcctgt atgggagcag    540

aagagtggtt gtgtgttcct gttcttcatc tgtgtgcggg gccatgtcac agagcgtcaa    600

cagattgtgt caggcaggaa tgctgcccgc ctttgcttca tctacagtca ggatgctgga    660

tgttcatgga gtgaggtgag ggacttgact gaggaggtca ttggctcaga gctgaagcac    720

tgggccacat ttgctgtggg cccaggtcat ggcatccagc tgcagtcagg gagactggtc    780

atccctgcgt atacctacta catcccttcc tggttctttt gcttccagct accatgtaaa    840

accaggcctc attctctgat gatctacagt gatgacctag gggtcacatg gcaccatggt    900

agactcatta ggcccatggt tacagtagaa tgtgaagtgg cagaggtgac tgggagggct    960

ggccaccctg tgctatattg cagtgcccgg acaccaaaca ggtgccgggc agaggcgctc   1020

agcactgacc atggtgaagg ctttcagaga ctggccctga gtcgacagct ctgtgagccc   1080

ccacatggtt gccaagggag tgtggtaagt ttccggcccc tggagatccc acataggtgc   1140

caggactcta gcagcaaaga tgcacccacc attcagcaga gctctccagg cagttcactg   1200

aggctggagg aggaagctgg aacaccgtca gaatcatggc tcttgtactc acacccaacc   1260

agtaggaaac agagggttga cctaggtatc tatctcaacc agaccccctt ggaggctgcc   1320

tgctggtccc gcccctggat cttgcactgt gggccctgtg gctactctga tctggctgct   1380

ctggaggagg agggcttgtt tgggtgtttg tttgaatgtg ggaccaagca agagtgtgag   1440

cagattgcct tccgcctgtt tacacaccgg gagatcctga gtcacctgca gggggactgc   1500

accagccctg gtaggaaccc aagccaattc aaaagcaatt aattggctta ggacccaatt   1560

tccatagatg caaatggcag ttacagacag gttaacagaa gctactgaag tctacagata   1620

atcaaaaaac ttaatattct gttccctacc ttttttcact tttcctcctc caaagagcaa   1680

aatgaaaatt ttgccttagc tactgcagtg gaaagagcac tgaactagga gttggaagac   1740

aaggatgtgg tcctggctct gccactggct tgcttttgga ccttggatgt gtcacctgaa   1800

ctctctggac ctcaggtttc catctgtaaa atgagagtat tggttctaag atttctcatc   1860

ttctcatccc taggacaagc atagtgcctg catgcttcat gatcagtaag tcctggctgc   1920

ataaaggact ctgatgtcaa aatggaaacc aggggactta ccttttcaca tgacttaccc   1980

ctcatccgag tgtgaggtta caagcaggtg tcatggcagg aaggaagacc agatctgtat   2040

gatttgttcc atttttaata acaaaaatat ccacaccctt ttaataatgc tcagttctgt   2100

aggctctcta tcctagagga attgagcaaa acagaagaat catgaagtct cctaccttct   2160

acagccttgt agttctgctt accttctctt cctcatccag aaagcatcat tttctaggga   2220

gaacaatgag aatctcaatg ccagtagtac tggataatag tgcgtattgc ttctggtggc   2280

attaccctga tgatgggctg aagttcattt attagggtgg ttcctgatgg gaaaaggaca   2340

tggattagga ctttaaaaca ctggacagaa tttcccacag tctttgccct caaggagttc   2400

accagtttat ggggctagaa gagcgagaaa attcaagaaa ataaatgtag ctggtgggag   2460

actttgtaga tgttgggcta tatgttgggg tgatggtagc tcctgatgta attttcttag   2520

ttgcatcttc aatatgcctg gagtcgtctg tccaaggctt gtccaggctt ctgggtttct   2580

ctcaagtttg tttttctcag gatattgtcc tggcccagct actcctttac ctgtgagaag   2640

atcttcacca ttaggaagat ctctagaccc ccagatctca gaatcaggcc tatttgtgta   2700

ggcccatgga aatcactact tgtgaagtag agatgccttt ttgtctaa                2748


<210>  419
<211>  461
<212>  PRT
<213>  Homo sapiens

<400>  419


Met Arg Pro Ala Asp Leu Pro Pro Arg Pro Met Glu Glu Ser Pro Ala 
1               5                   10                  15      


Ser Ser Ser Ala Pro Thr Glu Thr Glu Glu Pro Gly Ser Ser Ala Glu 
            20                  25                  30          


Val Met Glu Glu Val Thr Thr Cys Ser Phe Asn Ser Pro Leu Phe Arg 
        35                  40                  45              


Gln Glu Asp Asp Arg Gly Ile Thr Tyr Arg Ile Pro Ala Leu Leu Tyr 
    50                  55                  60                  


Ile Pro Pro Thr His Thr Phe Leu Ala Phe Ala Glu Lys Arg Ser Thr 
65                  70                  75                  80  


Arg Arg Asp Glu Asp Ala Leu His Leu Val Leu Arg Arg Gly Leu Arg 
                85                  90                  95      


Ile Gly Gln Leu Val Gln Trp Gly Pro Leu Lys Pro Leu Met Glu Ala 
            100                 105                 110         


Thr Leu Pro Gly His Arg Thr Met Asn Pro Cys Pro Val Trp Glu Gln 
        115                 120                 125             


Lys Ser Gly Cys Val Phe Leu Phe Phe Ile Cys Val Arg Gly His Val 
    130                 135                 140                 


Thr Glu Arg Gln Gln Ile Val Ser Gly Arg Asn Ala Ala Arg Leu Cys 
145                 150                 155                 160 


Phe Ile Tyr Ser Gln Asp Ala Gly Cys Ser Trp Ser Glu Val Arg Asp 
                165                 170                 175     


Leu Thr Glu Glu Val Ile Gly Ser Glu Leu Lys His Trp Ala Thr Phe 
            180                 185                 190         


Ala Val Gly Pro Gly His Gly Ile Gln Leu Gln Ser Gly Arg Leu Val 
        195                 200                 205             


Ile Pro Ala Tyr Thr Tyr Tyr Ile Pro Ser Trp Phe Phe Cys Phe Gln 
    210                 215                 220                 


Leu Pro Cys Lys Thr Arg Pro His Ser Leu Met Ile Tyr Ser Asp Asp 
225                 230                 235                 240 


Leu Gly Val Thr Trp His His Gly Arg Leu Ile Arg Pro Met Val Thr 
                245                 250                 255     


Val Glu Cys Glu Val Ala Glu Val Thr Gly Arg Ala Gly His Pro Val 
            260                 265                 270         


Leu Tyr Cys Ser Ala Arg Thr Pro Asn Arg Cys Arg Ala Glu Ala Leu 
        275                 280                 285             


Ser Thr Asp His Gly Glu Gly Phe Gln Arg Leu Ala Leu Ser Arg Gln 
    290                 295                 300                 


Leu Cys Glu Pro Pro His Gly Cys Gln Gly Ser Val Val Ser Phe Arg 
305                 310                 315                 320 


Pro Leu Glu Ile Pro His Arg Cys Gln Asp Ser Ser Ser Lys Asp Ala 
                325                 330                 335     


Pro Thr Ile Gln Gln Ser Ser Pro Gly Ser Ser Leu Arg Leu Glu Glu 
            340                 345                 350         


Glu Ala Gly Thr Pro Ser Glu Ser Trp Leu Leu Tyr Ser His Pro Thr 
        355                 360                 365             


Ser Arg Lys Gln Arg Val Asp Leu Gly Ile Tyr Leu Asn Gln Thr Pro 
    370                 375                 380                 


Leu Glu Ala Ala Cys Trp Ser Arg Pro Trp Ile Leu His Cys Gly Pro 
385                 390                 395                 400 


Cys Gly Tyr Ser Asp Leu Ala Ala Leu Glu Glu Glu Gly Leu Phe Gly 
                405                 410                 415     


Cys Leu Phe Glu Cys Gly Thr Lys Gln Glu Cys Glu Gln Ile Ala Phe 
            420                 425                 430         


Arg Leu Phe Thr His Arg Glu Ile Leu Ser His Leu Gln Gly Asp Cys 
        435                 440                 445             


Thr Ser Pro Gly Arg Asn Pro Ser Gln Phe Lys Ser Asn 
    450                 455                 460     

<210>  420
<211>  1102
<212>  DNA
<213>  Homo sapiens

<400>  420
atgatgttgg tgtgccacca cccattcaaa gattcgatgg acctggacat gagccccctg     60

aggccccaga actatctttt cagttgtgaa ctaaaggccg acaaagatga tcactttaag    120

gtggatagtg atgaaaatga gaccagttat ctttaagaac ggtcagttta gaggctggtg    180

caaaggattg cacgttgttg aagcagaggc catgaattgc gaaggcagtc aattaaggta    240

acactggcaa ctttgaaaat gtctgtacag ccaacagtta ccctgtgggg ctttgaaata    300

acaccacctt acggttgaag tgtgcttcag ggccagtgca tattagtggg cagcacttag    360

tagttgtgga ggaagatgta gagtcagaag atgaagagga ggatgtgaaa ctcttgagta    420

tatctagaaa gcagtctgct cctgaaggtg gtagcaaggt tccacagaaa aaagaaaaac    480

ttgctgcaga tgaagatgat gacaacaatg aagaggatga tgatgatgaa gaggaggagg    540

aggatgattt cgatgatgag gaaactgaag aaaaagcacc agtgaagaaa tctatacgag    600

atactccagc caaaaatgca caaaagtcaa atcagaatgg aaaagactca aaaccatcaa    660

caccaagatc aaaaggacaa gaatccttca aaaaaaaaaa aacaggaaaa aactcctaaa    720

acaccaaaag gacctagttt tgtagacgac attaaagcaa aaatgcaagc aagtatagga    780

aaaggtggtt ctcttcccaa agtggaagcc aagttcatca gttatgtgaa gaattgcttc    840

cagatgactg accaggaggc tattcaagat ctctggcagt ggaggaagtc tctttaagaa    900

aatagtttaa gcaatttgtt aaaaattttt tgtcttattt catttctgta acagttgata    960

tctggctgtc ctttttatga tgcagaatga gaattttccc tgctgtgttt gataaatgtt   1020

gtccaggttc cattgccaac aatgtgttgt ccaaaatgcc tgtttagttt ttaaagatgg   1080

aactccaccc tttgcttggt tt                                            1102


<210>  421
<211>  963
<212>  DNA
<213>  Homo sapiens

<400>  421
atggatgcca cagcctgtaa tgaatcagtg gatggctcac ccgtcttcta tctattgggc     60

atcccctctc tgccagagac cttcttcctc cctgtgtttt ttattttcct cctcttctac    120

cttctcatcc tgatgggtaa tgccctgatc ctggtggccg tggtggcaga gcccagcctc    180

cacaagccca tgtacttctt tctgatcaat ctctccacct tggacatcct tttcaccaca    240

accactgtcc ccaagatgct gtccttattc ttgcttgggg accgcttcct cagcttttct    300

tcctgcttac tgcagatgta cctcttccaa agttttacat gttcagaagc cttcatcctg    360

gtggtcatgg cctatgaccg ctatgtggct atctgccacc cactgcacta ccctgtcctc    420

atgaacccac agaccaatgc taccttggca gccagtgcct ggctaactgc cctcctcctg    480

cccatcccag cagtagtaag gacctcccag atggcatata acagcattgc ctacatctac    540

cactgcttct gtgatcatct ggctgtggtc caggcctcct gctctgacac caccccccag    600

accctcatgg gcttctgcat cgccatggtg gtgtccttcc tcccccttct cctggtgctt    660

ctctcctatg tccacatcct ggcctcagtg cttcgcatca gttccctaga aggacgggca    720

aaagccttct ccacctgcag ctcccacctt ctggtcgtgg gcacctacta ctcatctatt    780

gccatagcct acgtggccta cagggctgac ctgccccttg acttccatat catgggcaat    840

gtggtatatg ccattctcac accaattctc aaccccctca tttacacgct gagaaacagg    900

gatgtaaagg cagccatcac caaaatcatg tctcaagacc caggctgtga caggagcatt    960

tga                                                                  963


<210>  422
<211>  320
<212>  PRT
<213>  Homo sapiens

<400>  422


Met Asp Ala Thr Ala Cys Asn Glu Ser Val Asp Gly Ser Pro Val Phe 
1               5                   10                  15      


Tyr Leu Leu Gly Ile Pro Ser Leu Pro Glu Thr Phe Phe Leu Pro Val 
            20                  25                  30          


Phe Phe Ile Phe Leu Leu Phe Tyr Leu Leu Ile Leu Met Gly Asn Ala 
        35                  40                  45              


Leu Ile Leu Val Ala Val Val Ala Glu Pro Ser Leu His Lys Pro Met 
    50                  55                  60                  


Tyr Phe Phe Leu Ile Asn Leu Ser Thr Leu Asp Ile Leu Phe Thr Thr 
65                  70                  75                  80  


Thr Thr Val Pro Lys Met Leu Ser Leu Phe Leu Leu Gly Asp Arg Phe 
                85                  90                  95      


Leu Ser Phe Ser Ser Cys Leu Leu Gln Met Tyr Leu Phe Gln Ser Phe 
            100                 105                 110         


Thr Cys Ser Glu Ala Phe Ile Leu Val Val Met Ala Tyr Asp Arg Tyr 
        115                 120                 125             


Val Ala Ile Cys His Pro Leu His Tyr Pro Val Leu Met Asn Pro Gln 
    130                 135                 140                 


Thr Asn Ala Thr Leu Ala Ala Ser Ala Trp Leu Thr Ala Leu Leu Leu 
145                 150                 155                 160 


Pro Ile Pro Ala Val Val Arg Thr Ser Gln Met Ala Tyr Asn Ser Ile 
                165                 170                 175     


Ala Tyr Ile Tyr His Cys Phe Cys Asp His Leu Ala Val Val Gln Ala 
            180                 185                 190         


Ser Cys Ser Asp Thr Thr Pro Gln Thr Leu Met Gly Phe Cys Ile Ala 
        195                 200                 205             


Met Val Val Ser Phe Leu Pro Leu Leu Leu Val Leu Leu Ser Tyr Val 
    210                 215                 220                 


His Ile Leu Ala Ser Val Leu Arg Ile Ser Ser Leu Glu Gly Arg Ala 
225                 230                 235                 240 


Lys Ala Phe Ser Thr Cys Ser Ser His Leu Leu Val Val Gly Thr Tyr 
                245                 250                 255     


Tyr Ser Ser Ile Ala Ile Ala Tyr Val Ala Tyr Arg Ala Asp Leu Pro 
            260                 265                 270         


Leu Asp Phe His Ile Met Gly Asn Val Val Tyr Ala Ile Leu Thr Pro 
        275                 280                 285             


Ile Leu Asn Pro Leu Ile Tyr Thr Leu Arg Asn Arg Asp Val Lys Ala 
    290                 295                 300                 


Ala Ile Thr Lys Ile Met Ser Gln Asp Pro Gly Cys Asp Arg Ser Ile 
305                 310                 315                 320 

<210>  423
<211>  3202
<212>  DNA
<213>  Homo sapiens

<400>  423
atgccgaact tctgcgctgc ccccaactgc acgcggaaga gcacgcagtc cgacttggcc     60

ttcttcaggt tcccgcggga ccctgccaga tgccagaagt gggtggagaa ctgtaggaga    120

gcagacttag aagataaaac acctgatcag ctaaataaac attatcgatt atgtgccaaa    180

cattttgaga cctctatgat ctgtagaact agtccttata ggacagttct tcgagataat    240

gcaataccaa caatatttga tcttaccagt catttgaaca acccacatag tagacacaga    300

aaacgaataa aagaactgag tgaagatgaa atcaggacac tgaaacagaa aaaaattgat    360

gaaacttctg agcaggaaca aaaacataaa gaaaccaaca atagcaatgc tcagaacccc    420

agcgaagaag agggtgaagg gcaagatgag gacattttac ctctaaccct tgaagagaag    480

gaaaacaaag aatacctaaa atctctattt gaaatcttga ttctgatggg aaagcaaaac    540

atacctctgg atggacatga ggctgatgaa atcccagaag gtctctttac tccagataac    600

tttcaggcac tgctggagtg tcggataaat tctggtgaag aggttctgag aaagcggttt    660

gagacaacag cagttaacac gttgttttgt tcaaaaacac agcagaggca gatgctagag    720

atctgtgaga gctgtattcg agaagaaact ctcagggaag tgagagactc acacttcttt    780

tccattatca ctgacgatgt agtggacata gcaggggaag agcacctacc tgtgttggtg    840

aggtttgttg atgaatctca taacctaaga gaggaattta taggcttcct gccttatgaa    900

gccgatgcag aaattttggc tgtgaaattt cacactatga taactgagaa gtggggatta    960

aatatggagt attgtcgtgg ccaggcttac attgtctcta gtggattttc ttccaaaatg   1020

aaagttgttg cttctagact tttagagaaa tatccccaag ctatctacac actctgctct   1080

tcctgtgcct taaatatgtg gttggcaaaa tcagtacctg ttatgggagt atctgttgca   1140

ttaggaacaa ttgaggaagt ttgttctttt ttccatcgat caccacaact gcttttagaa   1200

cttgacaacg taatttctgt tctttttcag aacagtaaag aaaggggtaa agaactgaag   1260

gaaatctgcc attctcagtg gacaggcagg catgatgctt ttgaaatttt agtggaactc   1320

ctgcaagcac ttgttttatg tttagatggt ataaatagtg acacaaatat tagatggaat   1380

aactatatag ctggccgagc atttgtactc tgcagtgcag tgtcagattt tgatttcatt   1440

gttactattg ttgttcttaa aaatgtccta tcttttacaa gagcctttgg gaaaaacctc   1500

caggggcaaa cctctgatgt cttctttgcg gccggtagct tgactgcagt actgcattca   1560

ctcaacgaag tgatggaaaa tattgaagtt tatcatgaat tttggtttga ggaagccaca   1620

aatttggcaa ccaaacttga tattcaaatg aaactccctg ggaaattccg cagagctcac   1680

cagggtaact tggaatctca gctaacctct gagagttact ataaagaaac cctaagtgtc   1740

ccaacagtgg agcacattat tcaggaactt aaagatatat tctcagaaca gcacctcaaa   1800

gctcttaaat gcttatctct ggtaccctca gtcatgggac aactcaaatt caatacgtcg   1860

gaggaacacc atgctgacat gtatagaagt gacttaccca atcctgacac gctgtcagct   1920

gagcttcatt gttggagaat caaatggaaa cacaggggga aagatataga gcttccgtcc   1980

accatctatg aagccctcca cctgcctgac atcaagtttt ttcctaatgt gtatgcattg   2040

ctgaaggtcc tgtgtattct tcctgtgatg aaggttgaga atgagcggta tgaaaatgga   2100

cgaaagcgtc ttaaagcata tttgaggaac actttgacag accaaaggtc aagtaacttg   2160

gctttgctta acataaattt tgatataaaa cacgacctgg atttaatggt ggacacatat   2220

attaaactct atacaagtaa gtcagagctt cctacagata attccgaaac tgtggaaaat   2280

acctaagaga cttttaaaaa taggctttct tatatttgat atttggaaga aaaagccgta   2340

aggtgtatgt agaccactta atcactaaat atctttgcct ataggactcc attgaataca   2400

ttagccattg ataatctacc tgtttaaatg gcccctgttt gaactctcaa gctttgaaga   2460

cctacctgtt cttccagaag agaacgttga aagtgccatg tttccttttg cgtgatctct   2520

gttgatggca ctctggaatt gtttcagtta agtcatttta gacatagcat ttattatcac   2580

tgtggatctc tacttgttgg gtgttatgaa ttctttgaag aaatatattt tgaagaggtg   2640

tgggaggaag gaatacattt tataaaatgt tgtagtgaag cccacaattg acctttgact   2700

aataggagtt ttaagtatgt taaaaatcta tactggacag ttacaagaaa ttaccggaga   2760

aaagcttgtg agctcaccaa acaaggattt cagtgtagat tttgtctttc ttgaacttaa   2820

agaaacaaat gacaaagttt gaatggaaaa gcctgctgtt gttccacatc tcgttgctgt   2880

ttacattcct ttgtggagcc tgcatcttcc taagcttttt agcaggtata tgttgaacac   2940

ttctgtttca tggttgagac agaatcagag gccatggata ctgacaactg atttgtctgt   3000

tttttttctc tgtctttttc catgactctt atatactgcc tcatcttgat ttataagcaa   3060

aacctggaaa acctacaaaa taagtgttgt ggtttatcta gaaaaatatg gaaaatattg   3120

ctgttatttt tggtgaagaa aatcaatttt gtatagttta tttcaatcta aataaaatgt   3180

gaattttgtt aaaaaaaaaa aa                                            3202


<210>  424
<211>  761
<212>  PRT
<213>  Homo sapiens

<400>  424


Met Pro Asn Phe Cys Ala Ala Pro Asn Cys Thr Arg Lys Ser Thr Gln 
1               5                   10                  15      


Ser Asp Leu Ala Phe Phe Arg Phe Pro Arg Asp Pro Ala Arg Cys Gln 
            20                  25                  30          


Lys Trp Val Glu Asn Cys Arg Arg Ala Asp Leu Glu Asp Lys Thr Pro 
        35                  40                  45              


Asp Gln Leu Asn Lys His Tyr Arg Leu Cys Ala Lys His Phe Glu Thr 
    50                  55                  60                  


Ser Met Ile Cys Arg Thr Ser Pro Tyr Arg Thr Val Leu Arg Asp Asn 
65                  70                  75                  80  


Ala Ile Pro Thr Ile Phe Asp Leu Thr Ser His Leu Asn Asn Pro His 
                85                  90                  95      


Ser Arg His Arg Lys Arg Ile Lys Glu Leu Ser Glu Asp Glu Ile Arg 
            100                 105                 110         


Thr Leu Lys Gln Lys Lys Ile Asp Glu Thr Ser Glu Gln Glu Gln Lys 
        115                 120                 125             


His Lys Glu Thr Asn Asn Ser Asn Ala Gln Asn Pro Ser Glu Glu Glu 
    130                 135                 140                 


Gly Glu Gly Gln Asp Glu Asp Ile Leu Pro Leu Thr Leu Glu Glu Lys 
145                 150                 155                 160 


Glu Asn Lys Glu Tyr Leu Lys Ser Leu Phe Glu Ile Leu Ile Leu Met 
                165                 170                 175     


Gly Lys Gln Asn Ile Pro Leu Asp Gly His Glu Ala Asp Glu Ile Pro 
            180                 185                 190         


Glu Gly Leu Phe Thr Pro Asp Asn Phe Gln Ala Leu Leu Glu Cys Arg 
        195                 200                 205             


Ile Asn Ser Gly Glu Glu Val Leu Arg Lys Arg Phe Glu Thr Thr Ala 
    210                 215                 220                 


Val Asn Thr Leu Phe Cys Ser Lys Thr Gln Gln Arg Gln Met Leu Glu 
225                 230                 235                 240 


Ile Cys Glu Ser Cys Ile Arg Glu Glu Thr Leu Arg Glu Val Arg Asp 
                245                 250                 255     


Ser His Phe Phe Ser Ile Ile Thr Asp Asp Val Val Asp Ile Ala Gly 
            260                 265                 270         


Glu Glu His Leu Pro Val Leu Val Arg Phe Val Asp Glu Ser His Asn 
        275                 280                 285             


Leu Arg Glu Glu Phe Ile Gly Phe Leu Pro Tyr Glu Ala Asp Ala Glu 
    290                 295                 300                 


Ile Leu Ala Val Lys Phe His Thr Met Ile Thr Glu Lys Trp Gly Leu 
305                 310                 315                 320 


Asn Met Glu Tyr Cys Arg Gly Gln Ala Tyr Ile Val Ser Ser Gly Phe 
                325                 330                 335     


Ser Ser Lys Met Lys Val Val Ala Ser Arg Leu Leu Glu Lys Tyr Pro 
            340                 345                 350         


Gln Ala Ile Tyr Thr Leu Cys Ser Ser Cys Ala Leu Asn Met Trp Leu 
        355                 360                 365             


Ala Lys Ser Val Pro Val Met Gly Val Ser Val Ala Leu Gly Thr Ile 
    370                 375                 380                 


Glu Glu Val Cys Ser Phe Phe His Arg Ser Pro Gln Leu Leu Leu Glu 
385                 390                 395                 400 


Leu Asp Asn Val Ile Ser Val Leu Phe Gln Asn Ser Lys Glu Arg Gly 
                405                 410                 415     


Lys Glu Leu Lys Glu Ile Cys His Ser Gln Trp Thr Gly Arg His Asp 
            420                 425                 430         


Ala Phe Glu Ile Leu Val Glu Leu Leu Gln Ala Leu Val Leu Cys Leu 
        435                 440                 445             


Asp Gly Ile Asn Ser Asp Thr Asn Ile Arg Trp Asn Asn Tyr Ile Ala 
    450                 455                 460                 


Gly Arg Ala Phe Val Leu Cys Ser Ala Val Ser Asp Phe Asp Phe Ile 
465                 470                 475                 480 


Val Thr Ile Val Val Leu Lys Asn Val Leu Ser Phe Thr Arg Ala Phe 
                485                 490                 495     


Gly Lys Asn Leu Gln Gly Gln Thr Ser Asp Val Phe Phe Ala Ala Gly 
            500                 505                 510         


Ser Leu Thr Ala Val Leu His Ser Leu Asn Glu Val Met Glu Asn Ile 
        515                 520                 525             


Glu Val Tyr His Glu Phe Trp Phe Glu Glu Ala Thr Asn Leu Ala Thr 
    530                 535                 540                 


Lys Leu Asp Ile Gln Met Lys Leu Pro Gly Lys Phe Arg Arg Ala His 
545                 550                 555                 560 


Gln Gly Asn Leu Glu Ser Gln Leu Thr Ser Glu Ser Tyr Tyr Lys Glu 
                565                 570                 575     


Thr Leu Ser Val Pro Thr Val Glu His Ile Ile Gln Glu Leu Lys Asp 
            580                 585                 590         


Ile Phe Ser Glu Gln His Leu Lys Ala Leu Lys Cys Leu Ser Leu Val 
        595                 600                 605             


Pro Ser Val Met Gly Gln Leu Lys Phe Asn Thr Ser Glu Glu His His 
    610                 615                 620                 


Ala Asp Met Tyr Arg Ser Asp Leu Pro Asn Pro Asp Thr Leu Ser Ala 
625                 630                 635                 640 


Glu Leu His Cys Trp Arg Ile Lys Trp Lys His Arg Gly Lys Asp Ile 
                645                 650                 655     


Glu Leu Pro Ser Thr Ile Tyr Glu Ala Leu His Leu Pro Asp Ile Lys 
            660                 665                 670         


Phe Phe Pro Asn Val Tyr Ala Leu Leu Lys Val Leu Cys Ile Leu Pro 
        675                 680                 685             


Val Met Lys Val Glu Asn Glu Arg Tyr Glu Asn Gly Arg Lys Arg Leu 
    690                 695                 700                 


Lys Ala Tyr Leu Arg Asn Thr Leu Thr Asp Gln Arg Ser Ser Asn Leu 
705                 710                 715                 720 


Ala Leu Leu Asn Ile Asn Phe Asp Ile Lys His Asp Leu Asp Leu Met 
                725                 730                 735     


Val Asp Thr Tyr Ile Lys Leu Tyr Thr Ser Lys Ser Glu Leu Pro Thr 
            740                 745                 750         


Asp Asn Ser Glu Thr Val Glu Asn Thr 
        755                 760     

<210>  425
<211>  2828
<212>  DNA
<213>  Homo sapiens

<400>  425
tcatttgctt aaatttgcag ctgacggctg ccacctctct agaggcacct ggcggggagc     60

ctctcaacat aagacagtga ccagtctggt gactcacagc cggcacagcc atgaactacc    120

cgctaacgct ggaaatggac ctcgagaacc tggaggacct gttctgggaa ctggacagat    180

tggacaacta taacgacacc tccctggtgg aaaatcatct ctgccctgcc acagaggggc    240

ccctcatggc ctccttcaag gccgtgttcg tgcccgtggc ctacagcctc atcttcctcc    300

tgggcgtgat cggcaacgtc ctggtgctgg tgatcctgga gcggcaccgg cagacacgca    360

gttccacgga gaccttcctg ttccacctgg ccgtggccga cctcctgctg gtcttcatct    420

tgccctttgc cgtggccgag ggctctgtgg gctgggtcct ggggaccttc ctctgcaaaa    480

ctgtgattgc cctgcacaaa gtcaacttct actgcagcag cctgctcctg gcctgcatcg    540

ccgtggaccg ctacctggcc attgtccacg ccgtccatgc ctaccgccac cgccgcctcc    600

tctccatcca catcacctgt gggaccatct ggctggtggg cttcctcctt gccttgccag    660

agattctctt cgccaaagtc agccaaggcc atcacaacaa ctccctgcca cgttgcacct    720

tctcccaaga gaaccaagca gaaacgcatg cctggttcac ctcccgattc ctctaccatg    780

tggcgggatt cctgctgccc atgctggtga tgggctggtg ctacgtgggg gtagtgcaca    840

ggttgcgcca ggcccagcgg cgccctcagc ggcagaaggc agtcagggtg gccatcctgg    900

tgacaagcat cttcttcctc tgctggtcac cctaccacat cgtcatcttc ctggacaccc    960

tggcgaggct gaaggccgtg gacaatacct gcaagctgaa tggctctctc cccgtggcca   1020

tcaccatgtg tgagttcctg ggcctggccc actgctgcct caaccccatg ctctacactt   1080

tcgccggcgt gaagttccgc agtgacctgt cgcggctcct gacgaagctg ggctgtaccg   1140

gccctgcctc cctgtgccag ctcttcccta gctggcgcag gagcagtctc tctgagtcag   1200

agaatgccac ctctctcacc acgttctagg tcccagtgtc cccttttatt gctgcttttc   1260

cttggggcag gcagtgatgc tggatgctcc ttccaacagg agctgggatc ctaagggctc   1320

accgtggcta agagtgtcct aggagtatcc tcatttgggg tagctagagg aaccaacccc   1380

catttctaga acatccctgc cagctcttct gccggccctg gggctaggct ggagcccagg   1440

gagcggaaag cagctcaaag gcacagtgaa ggctgtcctt acccatctgc acccccctgg   1500

gctgagagaa cctcacgcac ctcccatcct aatcatccaa tgctcaagaa acaacttcta   1560

cttctgccct tgccaacgga gagcgcctgc ccctcccaga acacactcca tcagcttagg   1620

ggctgctgac ctccacagct tcccctctct cctcctgccc acctgtcaaa caaagccaga   1680

agctgagcac caggggatga gtggaggtta aggctgagga aaggccagct ggcagcagag   1740

tgtggccttc ggacaactca gtccctaaaa acacagacat tctgccaggc ccccaagcct   1800

gcagtcatct tgaccaagca ggaagctcag actggttgag ttcaggtagc tgcccctggc   1860

tctgaccgaa acagcgctgg gtccacccca tgtcaccgga tcctgggtgg tctgcaggca   1920

gggctgactc taggtgccct tggaggccag ccagtgacct gaggaagcgt gaaggccgag   1980

aagcaagaaa gaaacccgac agagggaaga aaagagcttt cttcccgaac cccaaggagg   2040

gagatggatc aatcaaaccc ggcggtcccc tccgccaggc gagatggggt ggggtggaga   2100

actcctaggg tggctgggtc caggggatgg gaggttgtgg gcattgatgg ggaaggaggc   2160

tggcttgtcc cctcctcact cccttcccat aagctataga cccgaggaaa ctcagagtcg   2220

gaacggagaa aggtggactg gaaggggccc gtgggagtca tctcaaccat cccctccgtg   2280

gcatcacctt aggcagggaa gtgtaagaaa cacactgagg cagggaagtc cccaggcccc   2340

aggaagccgt gccctgcccc cgtgaggatg tcactcagat ggaaccgcag gaagctgctc   2400

cgtgcttgtt tgctcacctg gggtgtggga ggcccgtccg gcagttctgg gtgctcccta   2460

ccacctcccc agcctttgat caggtgggga gtcagggacc cctgcccttg tcccactcaa   2520

gccaagcagc caagctcctt gggaggcccc actggggaaa taacagctgt ggctcacgtg   2580

agagtgtctt cacggcagga caacgaggaa gccctaagac gtcccttttt tctctgagta   2640

tctcctcgca agctgggtaa tcgatggggg agtctgaagc agatgcaaag aggcaagagg   2700

ctggattttg aattttcttt ttaataaaaa ggcacctata aaacaggtca atacagtaca   2760

ggcagcacag agacccccgg aacaagccta aaaattgttt caaaataaaa accaagaaga   2820

tgtcttca                                                            2828


<210>  426
<211>  372
<212>  PRT
<213>  Homo sapiens

<400>  426


Met Asn Tyr Pro Leu Thr Leu Glu Met Asp Leu Glu Asn Leu Glu Asp 
1               5                   10                  15      


Leu Phe Trp Glu Leu Asp Arg Leu Asp Asn Tyr Asn Asp Thr Ser Leu 
            20                  25                  30          


Val Glu Asn His Leu Cys Pro Ala Thr Glu Gly Pro Leu Met Ala Ser 
        35                  40                  45              


Phe Lys Ala Val Phe Val Pro Val Ala Tyr Ser Leu Ile Phe Leu Leu 
    50                  55                  60                  


Gly Val Ile Gly Asn Val Leu Val Leu Val Ile Leu Glu Arg His Arg 
65                  70                  75                  80  


Gln Thr Arg Ser Ser Thr Glu Thr Phe Leu Phe His Leu Ala Val Ala 
                85                  90                  95      


Asp Leu Leu Leu Val Phe Ile Leu Pro Phe Ala Val Ala Glu Gly Ser 
            100                 105                 110         


Val Gly Trp Val Leu Gly Thr Phe Leu Cys Lys Thr Val Ile Ala Leu 
        115                 120                 125             


His Lys Val Asn Phe Tyr Cys Ser Ser Leu Leu Leu Ala Cys Ile Ala 
    130                 135                 140                 


Val Asp Arg Tyr Leu Ala Ile Val His Ala Val His Ala Tyr Arg His 
145                 150                 155                 160 


Arg Arg Leu Leu Ser Ile His Ile Thr Cys Gly Thr Ile Trp Leu Val 
                165                 170                 175     


Gly Phe Leu Leu Ala Leu Pro Glu Ile Leu Phe Ala Lys Val Ser Gln 
            180                 185                 190         


Gly His His Asn Asn Ser Leu Pro Arg Cys Thr Phe Ser Gln Glu Asn 
        195                 200                 205             


Gln Ala Glu Thr His Ala Trp Phe Thr Ser Arg Phe Leu Tyr His Val 
    210                 215                 220                 


Ala Gly Phe Leu Leu Pro Met Leu Val Met Gly Trp Cys Tyr Val Gly 
225                 230                 235                 240 


Val Val His Arg Leu Arg Gln Ala Gln Arg Arg Pro Gln Arg Gln Lys 
                245                 250                 255     


Ala Val Arg Val Ala Ile Leu Val Thr Ser Ile Phe Phe Leu Cys Trp 
            260                 265                 270         


Ser Pro Tyr His Ile Val Ile Phe Leu Asp Thr Leu Ala Arg Leu Lys 
        275                 280                 285             


Ala Val Asp Asn Thr Cys Lys Leu Asn Gly Ser Leu Pro Val Ala Ile 
    290                 295                 300                 


Thr Met Cys Glu Phe Leu Gly Leu Ala His Cys Cys Leu Asn Pro Met 
305                 310                 315                 320 


Leu Tyr Thr Phe Ala Gly Val Lys Phe Arg Ser Asp Leu Ser Arg Leu 
                325                 330                 335     


Leu Thr Lys Leu Gly Cys Thr Gly Pro Ala Ser Leu Cys Gln Leu Phe 
            340                 345                 350         


Pro Ser Trp Arg Arg Ser Ser Leu Ser Glu Ser Glu Asn Ala Thr Ser 
        355                 360                 365             


Leu Thr Thr Phe 
    370         

<210>  427
<211>  2893
<212>  DNA
<213>  Homo sapiens

<400>  427
ccactctaag gaatgcggtc cctttgacag gcgaaaaact gaagttggaa aagacaaagt     60

gatttgttca aaattgaaat ttgaaacttg acatttggtc agtgggccct atgtaggaaa    120

aaacctccaa gagagctagg gttcctctca gagaggaaag acaggtcctt aggtcctcac    180

cctcccgtct ccttgccctt gcagttctgg gaactggaca gattggacaa ctataacgac    240

acctccctgg tggaaaatca tctctgccct gccacagagg ggcccctcat ggcctccttc    300

aaggccgtgt tcgtgcccgt ggcctacagc ctcatcttcc tcctgggcgt gatcggcaac    360

gtcctggtgc tggtgatcct ggagcggcac cggcagacac gcagttccac ggagaccttc    420

ctgttccacc tggccgtggc cgacctcctg ctggtcttca tcttgccctt tgccgtggcc    480

gagggctctg tgggctgggt cctggggacc ttcctctgca aaactgtgat tgccctgcac    540

aaagtcaact tctactgcag cagcctgctc ctggcctgca tcgccgtgga ccgctacctg    600

gccattgtcc acgccgtcca tgcctaccgc caccgccgcc tcctctccat ccacatcacc    660

tgtgggacca tctggctggt gggcttcctc cttgccttgc cagagattct cttcgccaaa    720

gtcagccaag gccatcacaa caactccctg ccacgttgca ccttctccca agagaaccaa    780

gcagaaacgc atgcctggtt cacctcccga ttcctctacc atgtggcggg attcctgctg    840

cccatgctgg tgatgggctg gtgctacgtg ggggtagtgc acaggttgcg ccaggcccag    900

cggcgccctc agcggcagaa ggcagtcagg gtggccatcc tggtgacaag catcttcttc    960

ctctgctggt caccctacca catcgtcatc ttcctggaca ccctggcgag gctgaaggcc   1020

gtggacaata cctgcaagct gaatggctct ctccccgtgg ccatcaccat gtgtgagttc   1080

ctgggcctgg cccactgctg cctcaacccc atgctctaca ctttcgccgg cgtgaagttc   1140

cgcagtgacc tgtcgcggct cctgacgaag ctgggctgta ccggccctgc ctccctgtgc   1200

cagctcttcc ctagctggcg caggagcagt ctctctgagt cagagaatgc cacctctctc   1260

accacgttct aggtcccagt gtcccctttt attgctgctt ttccttgggg caggcagtga   1320

tgctggatgc tccttccaac aggagctggg atcctaaggg ctcaccgtgg ctaagagtgt   1380

cctaggagta tcctcatttg gggtagctag aggaaccaac ccccatttct agaacatccc   1440

tgccagctct tctgccggcc ctggggctag gctggagccc agggagcgga aagcagctca   1500

aaggcacagt gaaggctgtc cttacccatc tgcacccccc tgggctgaga gaacctcacg   1560

cacctcccat cctaatcatc caatgctcaa gaaacaactt ctacttctgc ccttgccaac   1620

ggagagcgcc tgcccctccc agaacacact ccatcagctt aggggctgct gacctccaca   1680

gcttcccctc tctcctcctg cccacctgtc aaacaaagcc agaagctgag caccagggga   1740

tgagtggagg ttaaggctga ggaaaggcca gctggcagca gagtgtggcc ttcggacaac   1800

tcagtcccta aaaacacaga cattctgcca ggcccccaag cctgcagtca tcttgaccaa   1860

gcaggaagct cagactggtt gagttcaggt agctgcccct ggctctgacc gaaacagcgc   1920

tgggtccacc ccatgtcacc ggatcctggg tggtctgcag gcagggctga ctctaggtgc   1980

ccttggaggc cagccagtga cctgaggaag cgtgaaggcc gagaagcaag aaagaaaccc   2040

gacagaggga agaaaagagc tttcttcccg aaccccaagg agggagatgg atcaatcaaa   2100

cccggcggtc ccctccgcca ggcgagatgg ggtggggtgg agaactccta gggtggctgg   2160

gtccagggga tgggaggttg tgggcattga tggggaagga ggctggcttg tcccctcctc   2220

actcccttcc cataagctat agacccgagg aaactcagag tcggaacgga gaaaggtgga   2280

ctggaagggg cccgtgggag tcatctcaac catcccctcc gtggcatcac cttaggcagg   2340

gaagtgtaag aaacacactg aggcagggaa gtccccaggc cccaggaagc cgtgccctgc   2400

ccccgtgagg atgtcactca gatggaaccg caggaagctg ctccgtgctt gtttgctcac   2460

ctggggtgtg ggaggcccgt ccggcagttc tgggtgctcc ctaccacctc cccagccttt   2520

gatcaggtgg ggagtcaggg acccctgccc ttgtcccact caagccaagc agccaagctc   2580

cttgggaggc cccactgggg aaataacagc tgtggctcac gtgagagtgt cttcacggca   2640

ggacaacgag gaagccctaa gacgtccctt ttttctctga gtatctcctc gcaagctggg   2700

taatcgatgg gggagtctga agcagatgca aagaggcaag aggctggatt ttgaattttc   2760

tttttaataa aaaggcacct ataaaacagg tcaatacagt acaggcagca cagagacccc   2820

cggaacaagc ctaaaaattg tttcaaaata aaaaccaaga agatgtcttc aaaaaaaaaa   2880

aaaaaaaaaa aaa                                                      2893


<210>  428
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  428


Met Ala Ser Phe Lys Ala Val Phe Val Pro Val Ala Tyr Ser Leu Ile 
1               5                   10                  15      


Phe Leu Leu Gly Val Ile Gly Asn Val Leu Val Leu Val Ile Leu Glu 
            20                  25                  30          


Arg His Arg Gln Thr Arg Ser Ser Thr Glu Thr Phe Leu Phe His Leu 
        35                  40                  45              


Ala Val Ala Asp Leu Leu Leu Val Phe Ile Leu Pro Phe Ala Val Ala 
    50                  55                  60                  


Glu Gly Ser Val Gly Trp Val Leu Gly Thr Phe Leu Cys Lys Thr Val 
65                  70                  75                  80  


Ile Ala Leu His Lys Val Asn Phe Tyr Cys Ser Ser Leu Leu Leu Ala 
                85                  90                  95      


Cys Ile Ala Val Asp Arg Tyr Leu Ala Ile Val His Ala Val His Ala 
            100                 105                 110         


Tyr Arg His Arg Arg Leu Leu Ser Ile His Ile Thr Cys Gly Thr Ile 
        115                 120                 125             


Trp Leu Val Gly Phe Leu Leu Ala Leu Pro Glu Ile Leu Phe Ala Lys 
    130                 135                 140                 


Val Ser Gln Gly His His Asn Asn Ser Leu Pro Arg Cys Thr Phe Ser 
145                 150                 155                 160 


Gln Glu Asn Gln Ala Glu Thr His Ala Trp Phe Thr Ser Arg Phe Leu 
                165                 170                 175     


Tyr His Val Ala Gly Phe Leu Leu Pro Met Leu Val Met Gly Trp Cys 
            180                 185                 190         


Tyr Val Gly Val Val His Arg Leu Arg Gln Ala Gln Arg Arg Pro Gln 
        195                 200                 205             


Arg Gln Lys Ala Val Arg Val Ala Ile Leu Val Thr Ser Ile Phe Phe 
    210                 215                 220                 


Leu Cys Trp Ser Pro Tyr His Ile Val Ile Phe Leu Asp Thr Leu Ala 
225                 230                 235                 240 


Arg Leu Lys Ala Val Asp Asn Thr Cys Lys Leu Asn Gly Ser Leu Pro 
                245                 250                 255     


Val Ala Ile Thr Met Cys Glu Phe Leu Gly Leu Ala His Cys Cys Leu 
            260                 265                 270         


Asn Pro Met Leu Tyr Thr Phe Ala Gly Val Lys Phe Arg Ser Asp Leu 
        275                 280                 285             


Ser Arg Leu Leu Thr Lys Leu Gly Cys Thr Gly Pro Ala Ser Leu Cys 
    290                 295                 300                 


Gln Leu Phe Pro Ser Trp Arg Arg Ser Ser Leu Ser Glu Ser Glu Asn 
305                 310                 315                 320 


Ala Thr Ser Leu Thr Thr Phe 
                325         

<210>  429
<211>  7740
<212>  DNA
<213>  Homo sapiens

<400>  429
cgtgcgtgtc ttgtctccct gtccacgtgt gagctgtgag tgtgtgtgag tcagagttcg     60

ggtgtctgtg ggtctctgag cctctgctgg cagcacccgg ggctcgccaa gctcttgccg    120

gctggcgcgc gcccagcccc tggcgggact tgtccgtgtg tctgtccgcg cgcggggcct    180

ggagaagcac gctgcagtcc tgtccgcctc ccgctcgctg cctcgctggc tgtcgctcgc    240

tcgctctgcc tctccgcccg ggctctgccg aagggggcgg ggtgggggtg cagggcgggg    300

ggaggggagg ctcctgcatt cttgcggtcg gggaggaatc cgagccagcg ttactggtct    360

ccagaagagc ccagctgcag ccccggggcc ccgccaggcc tctcgctgcc cgcccgggcc    420

tgctgggatg ggcacgggct aggcctcgag ctggggacgg ggcggggcgt ggccccaacc    480

ccgggccccc tccacggctg gagcgctctg ggggtggggc acgaggggta ccccaccctg    540

ggtgaggggc gcgtctggga gcaggaatcc ctcagggggc caggggagac ctcacagccg    600

ccccacacgg cacctttgct acctagcctt ttagtgaatt ctgtctctgc cgcccgtcgg    660

ggcggaggct tgctggagac tgcaagcccc ctgagggcaa ggtgcgggag ggatggggac    720

agggctggcc tccaggatcg agaccccatc tcgtaatcct ctttttccag tgccacccca    780

ccctatccag ctccctagtc ccagggctgt tgggtcctcc cttctcccct ccccctctga    840

caccccctcc ccaagtcacg agttttctct ttggggcttg ttgctgcagt ccgtgctcca    900

gtaccgagta cctggctggg ccctgggcac gcacaggggc cgtagcccca ctgtgtgtgg    960

gagccatgag gatcctggct aacaagacaa ggttacccca ccccaggagg agagaagctc   1020

cagggagccc gccgctgtcc ccccgcggtc attgcccccc tgccccagcc aagccaatgc   1080

acccagaaaa taaattgacc aatcatggca agacagggaa tggcggggcc caatctcagc   1140

accagaatgt gaaccaagga cccacctgca acgtgggctc gaagggcgtg ggggcgggga   1200

accatggggc caaggccaac cagatctcgc ctagcaactc aagtctgaag aacccccagg   1260

caggggtgcc ccctttcagc tcgctcaagg gcaaggtgaa gagggaccgg agtgtgtctg   1320

tggactctgg agagcagcga gaggctggga ccccatccct ggattcagag gccaaagagg   1380

tggcgccgcg gagtaagcgg cgctgtgtgc tggagcggaa gcagccgtac agtggggacg   1440

aatggtgctc tggaccggac agtgaggagg acgacaagcc cattggggcc acccacaatt   1500

gtaatgtagc agacccagcc atggcggccc cacagctggg tcccggccaa accacccaac   1560

tgcccctcag cgagagcagc gtgccaggcg ccccgcacgg ccctcctcct ggccttcggc   1620

ctgatgcccc tgggggcggg ggcgggggcg ggggcgtccc cggaaagcct ccctcgcagt   1680

tcgtatatgt cttcaccacc cacctggcca acacggctgc agaggcagtg ctgcagggcc   1740

gggccgactc catcctcgcc taccaccagc agaacgtgcc ccgggccaag cttgaccagg   1800

cccctaaagt gccccccacc ccagaaccgc tacccctgag cacgccgtca gcaggcaccc   1860

cgcagtccca gccacctcca ctgccgccgc cgccaccccc ggcccctggc agtgccccgc   1920

ctgctctgcc cccagagggg cctcctgagg acagcagtca ggacctggcc cccaactcgg   1980

tgggagctgc cagcacaggt ggtgggactg ggggcaccca ccctaacacc ccgacggcta   2040

ccaccgccaa caaccctctg cctcctggag gagaccccag cagtgccccc ggccctgccc   2100

tgctggggga ggcagccgcc cctggaaatg ggcagcgcag cctggtgggc tcagagggct   2160

tgtccaaaga gcagctggag catcgggaac ggtccctcca gacgctgcga gacattgagc   2220

gactgctgct ccgcagcgga gagactgagc ccttcctcaa ggggccccca ggaggagcgg   2280

gtgagggggg cccaccagca caagcccccc ctccccccca gcagccaccc acggcccctc   2340

ccagcgggct gaagaaatat gaggaaccct tgcagtccat gatttcacag acacagagcc   2400

tagggggccc cccgctggag catgaagtgc ctgggcaccc cccgggtggg gacatggggc   2460

agcagatgaa catgatgata cagaggctgg gccaggacag cctcacgcct gagcaggtgg   2520

cctggcgcaa gctgcaggag gagtactacg aagagaaacg gcggaaagag gaacagattg   2580

ggctgcatgg gagccgtcct ctgcaggaca tgatgggcat ggggggcatg atggtgaggg   2640

ggcccccgcc tccttaccac agcaagcctg gggatcagtg gccacctgga atgggtgcgc   2700

agctgcgggg gcccatggat gttcaagatc ccatgcagct ccggggcgga cctccctttc   2760

ctgggccccg tttcccaggc aaccagatac aacgggtacc tgggtttggg ggcatgcaga   2820

gtatgcccat ggaggtgccc atgaatgcca tgcagaggcc cgtgagacca ggcatgggct   2880

ggaccgaaga cttgccccct atggggggac ccagcaattt tgcccagaac accatgccct   2940

acccaggtgg gcagggtgag gcggagcgat tcatgactcc ccgggtccgt gaggagctgc   3000

tgcggcacca gctgctggag aagcggtcga tgggcatgca gcgccccctg ggcatggcag   3060

gcagtggcat gggacagagc atggagatgg agcggatgat gcaggcgcac cgacagatgg   3120

atcctgccat gtttcccggg cagatggctg gtggtgaggg cctggcgggc actcccatgg   3180

gcatggagtt tggtggaggc cggggcctcc tgagccctcc catggggcag tctgggctga   3240

gggaggtgga cccacccatg gggccaggca acctcaacat gaacatgaat gtcaacatga   3300

acatgaacat gaacctgaac gtgcagatga ccccgcagca gcagatgctg atgtcgcaga   3360

agatgcgggg ccctggggac ttgatggggc cccagggcct cagtcctgag gagatggccc   3420

gggttcgggc ccagaacagc agtggcgtga tgggcggccc gcagaagatg ctgatgcctt   3480

cacagtttcc caaccagggc cagcagggat tctctggagg ccagggaccc taccaagcca   3540

tgtcccagga catgggcaat acccaagaca tgttcagccc tgatcagagc tcaatgccca   3600

tgagcaacgt gggcaccacc cggctcagcc acatgcctct gccccctgcg tccaatcctc   3660

ctgggaccgt gcattcagcc ccaaaccggg ggctaggcag gcggccttcg gacctcacca   3720

tcagtattaa tcagatgggc tcaccgggca tggggcactt gaagtcgccc acccttagcc   3780

aggtgcactc acccctggtc acctcgccct ctgccaacct caagtcaccc cagactccct   3840

cacagatggt gcccttgcct tctgccaacc cgccaggacc tctcaagtcg ccccaggtcc   3900

tcggctcctc cctcagtgtc cgttcaccca ctggctcgcc cagcaggctc aagtctcctt   3960

ccatggcggt gccttctcca ggctgggttg cctcacctaa gacggccatg cccagcccgg   4020

gggtctccca gaacaagcag ccgcctctca acatgaactc ttccaccacc ctgagcaaca   4080

tggaacaggg taccctcccg cctagcggcc cccggagcag ctcctcagca cctcccgcca   4140

accctcccag cggcctcatg aaccccagcc taccattcac ttcctcccca gaccccacac   4200

cttcccagaa ccccctgtca ctgatgatga cccagatgtc caagtacgcc atgcccagct   4260

ccaccccgct ctaccacaat gccatcaaga ccatcgccac ctcagacgac gagctgctgc   4320

ccgaccggcc cctgctgccc cccccaccac caccgcaggg ctccgggcca gggatcagca   4380

acagccagcc cagccagatg cacctgaact cagccgctgc ccagagccct atgggcatga   4440

acctgccagg ccagcagccc ctgtcccatg agcccccgcc cgccatgctg ccctccccca   4500

cccctctggg ctccaacatt ccactgcatc ccaacgcaca ggggacaggg gggccccctc   4560

aaaactccat gatgatggcc ccagggggcc ccgactccct gaatgccccc tgtggcccag   4620

tgcccagctc ctcccagatg atgcccttcc cccctcggct gcagcagccc catggtgcca   4680

tggcccccac tgggggtggg ggcggggggc ctggcctgca gcagcactac ccgtcaggca   4740

tggccctgcc tcccgaggac ctgcccaacc agccgccagg ccccatgcct ccccagcagc   4800

acctgatggg caaagccatg gctgggcgca tgggcgacgc atacccaccg ggtgtgctcc   4860

ctggggtggc atcagtgctg aacgaccccg agctgagcga ggtgatccgg cccaccccaa   4920

cggggatccc cgagttcgac ttgtcgagga tcatcccctc tgagaagcca agcagcaccc   4980

tccagtactt ccccaagagc gagaaccagc cccccaaggc tcagccccct aatctgcatc   5040

tcatgaacct gcagaacatg atggcggagc agactccctc tcggcctccc aacctcccag   5100

gccagcaggg cgtccagcgg gggctcaaca tgtccatgtg ccaccctgga cagatgtcct   5160

tgctgggcag gacaggcgtg cccccacagc aggggatggt gccccatggc ctgcaccagg   5220

gggtcatgtc ccctccacaa ggcctcatga cccagcagaa tttcatgctg atgaagcagc   5280

ggggcgtggg gggcgaggtc tacagccagc cgccccacat gctctccccg cagggctccc   5340

tcatgggccc cccgccccag cagaacctca tggtgtccca cccccttcgg cagcgcagtg   5400

tgtccctgga cagccagatg ggctacctcc cggcaccagg cggcatggcc aacctgccct   5460

tctagaagtc gctgccaggg ctggagccgg ggcaatgttg caaatacgat aaccttaaca   5520

aagttcttcc cctcaatgtt gggatggcct gggtcgcggg gtggggtgga gggggtggga   5580

gggggcttgt gtagggagtg gcatttgtgg aaaccagatg tgctggcagc ttagggggaa   5640

gtggcagtgt ggggtggggg attttgcatt ggggttggtt ccatttcggc caccaggact   5700

gcccctcccc cactcctccc aattcctatg gagcctctct attttacctc tttccgtgca   5760

tccctgcacc cgccacaccc ccttcagcta tgcttttgga gtcctggatg ggaatctggg   5820

gggagagagg aaggacaggt caggtctccc ccagcccctt ctgctcctgt ctcctcgtgt   5880

ccgcattgct ggagctccac ctccctcttg gtttctccgc acccgcccat tttccttctg   5940

tctttacctg cttcgtatcc tttccctgct gatgtggctg acccctctcc cacccctccc   6000

tgcaggcggc tggccaggtg ggcaggtgcc agccggagct gtaaatagag cgctgcgctt   6060

ttgtgctggt ttgtgcgtgt gctgtatttc tgtgttttga tagaagtcac acaaaaaaaa   6120

aaggataaaa gaaacccttc cccccttctt caagttattg ctccctccat tcccctggac   6180

ccagggacat gcagccctac atggccaccc actgtttgca gtgtctctgg gtccctaagg   6240

gataccattc ctgtctcgtc cccaaatggt aagatgacgt aaatgaccca ctcctaaact   6300

gaggtcagac cacctaggct tccacctggt gagccctagc agggctgaga cccccagggc   6360

ggcagcctgt ctgctgctga gtgattcagg gagaacatgt gtgcacgtgc atgtgtgttt   6420

gcccacaccg gtgacacggg gccctggctt tccactttgg atgcccgggc atccgctgct   6480

gctacatctt agccagaact tgaagtcttt tgtcccagtt tgggatgaag gaaaggagga   6540

agaggcggtg gctgtgtggc ccccttgagt ggagccatgg aaggggtggc atggtgccac   6600

tggggcctgt ggctgtagta gccctgggcc aggtaacctc cagggccctg acttttccag   6660

aggctgctgc cacctacttc ttatcaaaga agggggagaa cagttcatct gagtcagtgc   6720

acctcccctc cagtctccac tccctgagga tggaatcggg gaaacagcat cctgccgcct   6780

cctctctgcc tgcccactca ccggcaaggt tgtccctctg cccagggctc agggccatgt   6840

accagatctg tctgtgccca cccaggcaca gccactgcct cccccttggc tccctgctcc   6900

tacccaggag agctccctat ccgcctttgg tcagagctga agccatatac gactgggtgt   6960

ttgtccccct actttggccc caggagtaaa aaaacttctc cttttctcac ttcctttcct   7020

gcctcgggag gtggcagggc agttccctgg ctgaggcctt ttgcgcccca cctccaggac   7080

caagggccat tctagacagg gtgtcttcta ccaggacccg tccctagcct tcctggcctg   7140

gagggcctgg tcttgcactg gcagctgtaa tacaaaggga actcgcccca cttctcccag   7200

cctggtgctg tcctctcggc ccaccatcgg ccaggtccag cgcttcctct ggggctgaca   7260

acaggcccct gactcacccc ggtcacctcc cagggtccat ggccagggcc tctgtgtttg   7320

gggggccact tgcccttcat cctgccaggc gctttgcccg ccctgcctca gcctgggccc   7380

tgtgcccttg agccctccac ccctggccca agaccccccc aaactgtctg actctgtgtt   7440

tcctgccctg aggagagagg ggtcagattg cagcgggccg agtgccctct ccgtcccctc   7500

tcctcccacc cacgccacag gccagcctac tcttccctcc atccatggcc acacccccag   7560

ccattttgta ccattatata aatatatata taaatataaa tatataaata caatatgtga   7620

agacatcttc ttggttttta ttttgaaaca atttttaggc ttgttccggg ggtctctgtg   7680

ctgcctgtac tgtattgacc tgttttatag gtgccttttt attaaaaaga aaattcaaaa   7740


<210>  430
<211>  1499
<212>  PRT
<213>  Homo sapiens

<400>  430


Met Arg Ile Leu Ala Asn Lys Thr Arg Leu Pro His Pro Arg Arg Arg 
1               5                   10                  15      


Glu Ala Pro Gly Ser Pro Pro Leu Ser Pro Arg Gly His Cys Pro Pro 
            20                  25                  30          


Ala Pro Ala Lys Pro Met His Pro Glu Asn Lys Leu Thr Asn His Gly 
        35                  40                  45              


Lys Thr Gly Asn Gly Gly Ala Gln Ser Gln His Gln Asn Val Asn Gln 
    50                  55                  60                  


Gly Pro Thr Cys Asn Val Gly Ser Lys Gly Val Gly Ala Gly Asn His 
65                  70                  75                  80  


Gly Ala Lys Ala Asn Gln Ile Ser Pro Ser Asn Ser Ser Leu Lys Asn 
                85                  90                  95      


Pro Gln Ala Gly Val Pro Pro Phe Ser Ser Leu Lys Gly Lys Val Lys 
            100                 105                 110         


Arg Asp Arg Ser Val Ser Val Asp Ser Gly Glu Gln Arg Glu Ala Gly 
        115                 120                 125             


Thr Pro Ser Leu Asp Ser Glu Ala Lys Glu Val Ala Pro Arg Ser Lys 
    130                 135                 140                 


Arg Arg Cys Val Leu Glu Arg Lys Gln Pro Tyr Ser Gly Asp Glu Trp 
145                 150                 155                 160 


Cys Ser Gly Pro Asp Ser Glu Glu Asp Asp Lys Pro Ile Gly Ala Thr 
                165                 170                 175     


His Asn Cys Asn Val Ala Asp Pro Ala Met Ala Ala Pro Gln Leu Gly 
            180                 185                 190         


Pro Gly Gln Thr Thr Gln Leu Pro Leu Ser Glu Ser Ser Val Pro Gly 
        195                 200                 205             


Ala Pro His Gly Pro Pro Pro Gly Leu Arg Pro Asp Ala Pro Gly Gly 
    210                 215                 220                 


Gly Gly Gly Gly Gly Gly Val Pro Gly Lys Pro Pro Ser Gln Phe Val 
225                 230                 235                 240 


Tyr Val Phe Thr Thr His Leu Ala Asn Thr Ala Ala Glu Ala Val Leu 
                245                 250                 255     


Gln Gly Arg Ala Asp Ser Ile Leu Ala Tyr His Gln Gln Asn Val Pro 
            260                 265                 270         


Arg Ala Lys Leu Asp Gln Ala Pro Lys Val Pro Pro Thr Pro Glu Pro 
        275                 280                 285             


Leu Pro Leu Ser Thr Pro Ser Ala Gly Thr Pro Gln Ser Gln Pro Pro 
    290                 295                 300                 


Pro Leu Pro Pro Pro Pro Pro Pro Ala Pro Gly Ser Ala Pro Pro Ala 
305                 310                 315                 320 


Leu Pro Pro Glu Gly Pro Pro Glu Asp Ser Ser Gln Asp Leu Ala Pro 
                325                 330                 335     


Asn Ser Val Gly Ala Ala Ser Thr Gly Gly Gly Thr Gly Gly Thr His 
            340                 345                 350         


Pro Asn Thr Pro Thr Ala Thr Thr Ala Asn Asn Pro Leu Pro Pro Gly 
        355                 360                 365             


Gly Asp Pro Ser Ser Ala Pro Gly Pro Ala Leu Leu Gly Glu Ala Ala 
    370                 375                 380                 


Ala Pro Gly Asn Gly Gln Arg Ser Leu Val Gly Ser Glu Gly Leu Ser 
385                 390                 395                 400 


Lys Glu Gln Leu Glu His Arg Glu Arg Ser Leu Gln Thr Leu Arg Asp 
                405                 410                 415     


Ile Glu Arg Leu Leu Leu Arg Ser Gly Glu Thr Glu Pro Phe Leu Lys 
            420                 425                 430         


Gly Pro Pro Gly Gly Ala Gly Glu Gly Gly Pro Pro Ala Gln Ala Pro 
        435                 440                 445             


Pro Pro Pro Gln Gln Pro Pro Thr Ala Pro Pro Ser Gly Leu Lys Lys 
    450                 455                 460                 


Tyr Glu Glu Pro Leu Gln Ser Met Ile Ser Gln Thr Gln Ser Leu Gly 
465                 470                 475                 480 


Gly Pro Pro Leu Glu His Glu Val Pro Gly His Pro Pro Gly Gly Asp 
                485                 490                 495     


Met Gly Gln Gln Met Asn Met Met Ile Gln Arg Leu Gly Gln Asp Ser 
            500                 505                 510         


Leu Thr Pro Glu Gln Val Ala Trp Arg Lys Leu Gln Glu Glu Tyr Tyr 
        515                 520                 525             


Glu Glu Lys Arg Arg Lys Glu Glu Gln Ile Gly Leu His Gly Ser Arg 
    530                 535                 540                 


Pro Leu Gln Asp Met Met Gly Met Gly Gly Met Met Val Arg Gly Pro 
545                 550                 555                 560 


Pro Pro Pro Tyr His Ser Lys Pro Gly Asp Gln Trp Pro Pro Gly Met 
                565                 570                 575     


Gly Ala Gln Leu Arg Gly Pro Met Asp Val Gln Asp Pro Met Gln Leu 
            580                 585                 590         


Arg Gly Gly Pro Pro Phe Pro Gly Pro Arg Phe Pro Gly Asn Gln Ile 
        595                 600                 605             


Gln Arg Val Pro Gly Phe Gly Gly Met Gln Ser Met Pro Met Glu Val 
    610                 615                 620                 


Pro Met Asn Ala Met Gln Arg Pro Val Arg Pro Gly Met Gly Trp Thr 
625                 630                 635                 640 


Glu Asp Leu Pro Pro Met Gly Gly Pro Ser Asn Phe Ala Gln Asn Thr 
                645                 650                 655     


Met Pro Tyr Pro Gly Gly Gln Gly Glu Ala Glu Arg Phe Met Thr Pro 
            660                 665                 670         


Arg Val Arg Glu Glu Leu Leu Arg His Gln Leu Leu Glu Lys Arg Ser 
        675                 680                 685             


Met Gly Met Gln Arg Pro Leu Gly Met Ala Gly Ser Gly Met Gly Gln 
    690                 695                 700                 


Ser Met Glu Met Glu Arg Met Met Gln Ala His Arg Gln Met Asp Pro 
705                 710                 715                 720 


Ala Met Phe Pro Gly Gln Met Ala Gly Gly Glu Gly Leu Ala Gly Thr 
                725                 730                 735     


Pro Met Gly Met Glu Phe Gly Gly Gly Arg Gly Leu Leu Ser Pro Pro 
            740                 745                 750         


Met Gly Gln Ser Gly Leu Arg Glu Val Asp Pro Pro Met Gly Pro Gly 
        755                 760                 765             


Asn Leu Asn Met Asn Met Asn Val Asn Met Asn Met Asn Met Asn Leu 
    770                 775                 780                 


Asn Val Gln Met Thr Pro Gln Gln Gln Met Leu Met Ser Gln Lys Met 
785                 790                 795                 800 


Arg Gly Pro Gly Asp Leu Met Gly Pro Gln Gly Leu Ser Pro Glu Glu 
                805                 810                 815     


Met Ala Arg Val Arg Ala Gln Asn Ser Ser Gly Val Met Gly Gly Pro 
            820                 825                 830         


Gln Lys Met Leu Met Pro Ser Gln Phe Pro Asn Gln Gly Gln Gln Gly 
        835                 840                 845             


Phe Ser Gly Gly Gln Gly Pro Tyr Gln Ala Met Ser Gln Asp Met Gly 
    850                 855                 860                 


Asn Thr Gln Asp Met Phe Ser Pro Asp Gln Ser Ser Met Pro Met Ser 
865                 870                 875                 880 


Asn Val Gly Thr Thr Arg Leu Ser His Met Pro Leu Pro Pro Ala Ser 
                885                 890                 895     


Asn Pro Pro Gly Thr Val His Ser Ala Pro Asn Arg Gly Leu Gly Arg 
            900                 905                 910         


Arg Pro Ser Asp Leu Thr Ile Ser Ile Asn Gln Met Gly Ser Pro Gly 
        915                 920                 925             


Met Gly His Leu Lys Ser Pro Thr Leu Ser Gln Val His Ser Pro Leu 
    930                 935                 940                 


Val Thr Ser Pro Ser Ala Asn Leu Lys Ser Pro Gln Thr Pro Ser Gln 
945                 950                 955                 960 


Met Val Pro Leu Pro Ser Ala Asn Pro Pro Gly Pro Leu Lys Ser Pro 
                965                 970                 975     


Gln Val Leu Gly Ser Ser Leu Ser Val Arg Ser Pro Thr Gly Ser Pro 
            980                 985                 990         


Ser Arg Leu Lys Ser Pro Ser Met  Ala Val Pro Ser Pro  Gly Trp Val 
        995                 1000                 1005             


Ala Ser  Pro Lys Thr Ala Met  Pro Ser Pro Gly Val  Ser Gln Asn 
    1010                 1015                 1020             


Lys Gln  Pro Pro Leu Asn Met  Asn Ser Ser Thr Thr  Leu Ser Asn 
    1025                 1030                 1035             


Met Glu  Gln Gly Thr Leu Pro  Pro Ser Gly Pro Arg  Ser Ser Ser 
    1040                 1045                 1050             


Ser Ala  Pro Pro Ala Asn Pro  Pro Ser Gly Leu Met  Asn Pro Ser 
    1055                 1060                 1065             


Leu Pro  Phe Thr Ser Ser Pro  Asp Pro Thr Pro Ser  Gln Asn Pro 
    1070                 1075                 1080             


Leu Ser  Leu Met Met Thr Gln  Met Ser Lys Tyr Ala  Met Pro Ser 
    1085                 1090                 1095             


Ser Thr  Pro Leu Tyr His Asn  Ala Ile Lys Thr Ile  Ala Thr Ser 
    1100                 1105                 1110             


Asp Asp  Glu Leu Leu Pro Asp  Arg Pro Leu Leu Pro  Pro Pro Pro 
    1115                 1120                 1125             


Pro Pro  Gln Gly Ser Gly Pro  Gly Ile Ser Asn Ser  Gln Pro Ser 
    1130                 1135                 1140             


Gln Met  His Leu Asn Ser Ala  Ala Ala Gln Ser Pro  Met Gly Met 
    1145                 1150                 1155             


Asn Leu  Pro Gly Gln Gln Pro  Leu Ser His Glu Pro  Pro Pro Ala 
    1160                 1165                 1170             


Met Leu  Pro Ser Pro Thr Pro  Leu Gly Ser Asn Ile  Pro Leu His 
    1175                 1180                 1185             


Pro Asn  Ala Gln Gly Thr Gly  Gly Pro Pro Gln Asn  Ser Met Met 
    1190                 1195                 1200             


Met Ala  Pro Gly Gly Pro Asp  Ser Leu Asn Ala Pro  Cys Gly Pro 
    1205                 1210                 1215             


Val Pro  Ser Ser Ser Gln Met  Met Pro Phe Pro Pro  Arg Leu Gln 
    1220                 1225                 1230             


Gln Pro  His Gly Ala Met Ala  Pro Thr Gly Gly Gly  Gly Gly Gly 
    1235                 1240                 1245             


Pro Gly  Leu Gln Gln His Tyr  Pro Ser Gly Met Ala  Leu Pro Pro 
    1250                 1255                 1260             


Glu Asp  Leu Pro Asn Gln Pro  Pro Gly Pro Met Pro  Pro Gln Gln 
    1265                 1270                 1275             


His Leu  Met Gly Lys Ala Met  Ala Gly Arg Met Gly  Asp Ala Tyr 
    1280                 1285                 1290             


Pro Pro  Gly Val Leu Pro Gly  Val Ala Ser Val Leu  Asn Asp Pro 
    1295                 1300                 1305             


Glu Leu  Ser Glu Val Ile Arg  Pro Thr Pro Thr Gly  Ile Pro Glu 
    1310                 1315                 1320             


Phe Asp  Leu Ser Arg Ile Ile  Pro Ser Glu Lys Pro  Ser Ser Thr 
    1325                 1330                 1335             


Leu Gln  Tyr Phe Pro Lys Ser  Glu Asn Gln Pro Pro  Lys Ala Gln 
    1340                 1345                 1350             


Pro Pro  Asn Leu His Leu Met  Asn Leu Gln Asn Met  Met Ala Glu 
    1355                 1360                 1365             


Gln Thr  Pro Ser Arg Pro Pro  Asn Leu Pro Gly Gln  Gln Gly Val 
    1370                 1375                 1380             


Gln Arg  Gly Leu Asn Met Ser  Met Cys His Pro Gly  Gln Met Ser 
    1385                 1390                 1395             


Leu Leu  Gly Arg Thr Gly Val  Pro Pro Gln Gln Gly  Met Val Pro 
    1400                 1405                 1410             


His Gly  Leu His Gln Gly Val  Met Ser Pro Pro Gln  Gly Leu Met 
    1415                 1420                 1425             


Thr Gln  Gln Asn Phe Met Leu  Met Lys Gln Arg Gly  Val Gly Gly 
    1430                 1435                 1440             


Glu Val  Tyr Ser Gln Pro Pro  His Met Leu Ser Pro  Gln Gly Ser 
    1445                 1450                 1455             


Leu Met  Gly Pro Pro Pro Gln  Gln Asn Leu Met Val  Ser His Pro 
    1460                 1465                 1470             


Leu Arg  Gln Arg Ser Val Ser  Leu Asp Ser Gln Met  Gly Tyr Leu 
    1475                 1480                 1485             


Pro Ala  Pro Gly Gly Met Ala  Asn Leu Pro Phe 
    1490                 1495                 

<210>  431
<211>  2856
<212>  DNA
<213>  Homo sapiens

<400>  431
gcttcccata cggcagtggc tgggggagag tgatggagag aaaggctaag ctaaggtcaa     60

agaaagtgga ggaaggctgg cttgtcccgc tggacttgac ggcggagctg ctgcaatctc    120

gcgggctggg cccttgcccc gggtggaccc gagtgcctgc ggggaggcgg gtgtggctcc    180

cccgggaggt gacagctggc ggggcccgta aggagctggt ctgctccggc tcccctctcg    240

tagccggcgc cctgggacca gcgcgtgagc acgtctcgga ggagtccgat gcgctgggca    300

gggccgggtg gtcacccccg cccagcttcc aggggtgact gtgcctctga cgtcagacgg    360

tttttgggtc attccctggc acggggactt tattttcata acagcatgaa gtgccgtgga    420

actggaatag gcgtgtcctc tccctcgacc ctccccctcc ttgtccctct gctcacccct    480

cgctcgttcc ctccctccgg cgagggccgc ctttataaca actgctcaga gtgcgagggc    540

gggatagctg tccaaggtct cccccagcac tgaggagctc gcctgctgcc ctcttgcgcg    600

cgggaagcag caccaagttc acggccaacg ccttggcact agggtccaga atggctacaa    660

cagtccctga tggttgccgc aatggcctga aatccaagta ctacagactt tgtgataagg    720

ctgaagcttg gggcatcgtc ctagaaacgg tggccacagc cggggttgtg acctcggtgg    780

ccttcatgct cactctcccg atcctcgtct gcaaggtgca ggactccaac aggcgaaaaa    840

tgctgcctac tcagtttctc ttcctcctgg gtgtgttggg catctttggc ctcaccttcg    900

ccttcatcat cggactggac gggagcacag ggcccacacg cttcttcctc tttgggatcc    960

tcttttccat ctgcttctcc tgcctgctgg ctcatgctgt cagtctgacc aagctcgtcc   1020

gggggaggaa gcccctttcc ctgttggtga ttctgggtct ggccgtgggc ttcagcctag   1080

tccaggatgt tatcgctatt gaatatattg tcctgaccat gaataggacc aacgtcaatg   1140

tcttttctga gctttccgct cctcgtcgca atgaagactt tgtcctcctg ctcacctacg   1200

tcctcttctt gatggcgctg accttcctca tgtcctcctt caccttctgt ggttccttca   1260

cgggctggaa gagacatggg gcccacatct acctcacgat gctcctctcc attgccatct   1320

gggtggcctg gatcaccctg ctcatgcttc ctgactttga ccgcaggtgg gatgacacca   1380

tcctcagctc cgccttggct gccaatggct gggtgttcct gttggcttat gttagtcccg   1440

agttttggct gctcacaaag caacgaaacc ccatggatta tcctgttgag gatgctttct   1500

gtaaacctca actcgtgaag aagagctatg gtgtggagaa cagagcctac tctcaagagg   1560

aaatcactca aggttttgaa gagacagggg acacgctcta tgccccctat tccacacatt   1620

ttcagctgca gaaccagcct ccccaaaagg aattctccat cccacgggcc cacgcttggc   1680

cgagccctta caaagactat gaagtaaaga aagagggcag ctaactctgt cctgaagagt   1740

gggacaaatg cagccgggcg gcagatctag cgggagctca aagggatgtg ggcgaaatct   1800

tgagtcttct gagaaaactg tacaagacac tacgggaaca gtttgcctcc ctcccagcct   1860

caaccacaat tcttccatgc tggggctgat gtgggctagt aagactccag ttcttagagg   1920

cgctgtagta tttttttttt tttgtctcat cctttggata cttcttttaa gtgggagtct   1980

caggcaactc aagtttagac ccttactctt tttgtttgtt ttttgaaaca ggatcttgct   2040

ctgtcaccca ggcttgagtg cagtggtgcg atcacagccc agtgcagcct cgaccacctg   2100

tgctcaagca atcctcccat ctccatctcc caaagtgctg ggatgacagg cgtgagccac   2160

agctcccagc ctaggccctt aatcttgctg ttattttcca tggactaaag gtctggtcat   2220

ctgagctcac gctggctcac acagctctag gggcctgctc ctctaactca cagtgggttt   2280

tgtgaggctc tgtggcccag agcagacctg catatctgag caaaaatagc aaaagcctct   2340

ctcagcccac tggcctgaat ctacactgga agccaacttg ctggcacccc cgctccccaa   2400

cccttcttgc ctgggtagga gaggctaaag atcaccctaa atttactcat ctctctagtg   2460

ctgcctcaca ttgggcctca gcagctcccc agcaccaatt cacaggtcac ccctctcttc   2520

ttgcactgtc cccaaacttg ctgtcaattc cgagatctaa tctcccccta cgctctgcca   2580

ggaattcttt cagacctcac tagcacaagc ccggttgctc cttgtcagga gaatttgtag   2640

atcattctca cttcaaattc ctggggctga tacttctctc atcttgcacc ccaacctctg   2700

taaatagatt taccgcattt acggctgcat tctgtaagtg ggcatggtct cctaatggag   2760

gagtgttcat tgtataataa gttattcacc tgagtatgca ataaagatgt ggtggccact   2820

ctttcatggt ggtggcagca gttaccagta aaaaaa                             2856


<210>  432
<211>  357
<212>  PRT
<213>  Homo sapiens

<400>  432


Met Ala Thr Thr Val Pro Asp Gly Cys Arg Asn Gly Leu Lys Ser Lys 
1               5                   10                  15      


Tyr Tyr Arg Leu Cys Asp Lys Ala Glu Ala Trp Gly Ile Val Leu Glu 
            20                  25                  30          


Thr Val Ala Thr Ala Gly Val Val Thr Ser Val Ala Phe Met Leu Thr 
        35                  40                  45              


Leu Pro Ile Leu Val Cys Lys Val Gln Asp Ser Asn Arg Arg Lys Met 
    50                  55                  60                  


Leu Pro Thr Gln Phe Leu Phe Leu Leu Gly Val Leu Gly Ile Phe Gly 
65                  70                  75                  80  


Leu Thr Phe Ala Phe Ile Ile Gly Leu Asp Gly Ser Thr Gly Pro Thr 
                85                  90                  95      


Arg Phe Phe Leu Phe Gly Ile Leu Phe Ser Ile Cys Phe Ser Cys Leu 
            100                 105                 110         


Leu Ala His Ala Val Ser Leu Thr Lys Leu Val Arg Gly Arg Lys Pro 
        115                 120                 125             


Leu Ser Leu Leu Val Ile Leu Gly Leu Ala Val Gly Phe Ser Leu Val 
    130                 135                 140                 


Gln Asp Val Ile Ala Ile Glu Tyr Ile Val Leu Thr Met Asn Arg Thr 
145                 150                 155                 160 


Asn Val Asn Val Phe Ser Glu Leu Ser Ala Pro Arg Arg Asn Glu Asp 
                165                 170                 175     


Phe Val Leu Leu Leu Thr Tyr Val Leu Phe Leu Met Ala Leu Thr Phe 
            180                 185                 190         


Leu Met Ser Ser Phe Thr Phe Cys Gly Ser Phe Thr Gly Trp Lys Arg 
        195                 200                 205             


His Gly Ala His Ile Tyr Leu Thr Met Leu Leu Ser Ile Ala Ile Trp 
    210                 215                 220                 


Val Ala Trp Ile Thr Leu Leu Met Leu Pro Asp Phe Asp Arg Arg Trp 
225                 230                 235                 240 


Asp Asp Thr Ile Leu Ser Ser Ala Leu Ala Ala Asn Gly Trp Val Phe 
                245                 250                 255     


Leu Leu Ala Tyr Val Ser Pro Glu Phe Trp Leu Leu Thr Lys Gln Arg 
            260                 265                 270         


Asn Pro Met Asp Tyr Pro Val Glu Asp Ala Phe Cys Lys Pro Gln Leu 
        275                 280                 285             


Val Lys Lys Ser Tyr Gly Val Glu Asn Arg Ala Tyr Ser Gln Glu Glu 
    290                 295                 300                 


Ile Thr Gln Gly Phe Glu Glu Thr Gly Asp Thr Leu Tyr Ala Pro Tyr 
305                 310                 315                 320 


Ser Thr His Phe Gln Leu Gln Asn Gln Pro Pro Gln Lys Glu Phe Ser 
                325                 330                 335     


Ile Pro Arg Ala His Ala Trp Pro Ser Pro Tyr Lys Asp Tyr Glu Val 
            340                 345                 350         


Lys Lys Glu Gly Ser 
        355         

<210>  433
<211>  4190
<212>  DNA
<213>  Homo sapiens

<400>  433
agataaagca tttccttcca ttgtcatcct acccggccgg ccgggctgcc agggccctcc     60

ccctcccggc cccctccctt cctctcgccg tctcacagtc gctctgcagc ctccggcgac    120

tggggggatg tgaggccggc gccccagccc cccgccccgc catgagcccc ccgctctgag    180

ggccccggcc cctggatgca cagccccggc gctgatggga cccaggtgag cccgggtgcc    240

cactactgca gccccactgg cgcaggctgc cccaggccct gtgcagacac accaggccct    300

cagccgcagc ccatggacct gcgggtgggc cagcggcccc cagtggagcc cccaccagag    360

cccacattgc tggccctgca gcgtccccag cgcctgcacc accacctctt cctagcaggc    420

ctgcagcagc agcgctcggt ggagcccatg aggctctcca tggacacgcc gatgcccgag    480

ttgcaggtgg gaccccagga acaagagctg cggcagcttc tccacaagga caagagcaag    540

cgaagtgctg tagccagcag cgtggtcaag cagaagctag cggaggtgat tctgaaaaaa    600

cagcaggcgg ccctagaaag aacagtccat cccaacagcc ccggcattcc ctacagaacc    660

ctggagcccc tggagacgga aggagccacc cgctccatgc tcagcagctt tttgcctcct    720

gttcccagcc tgcccagtga ccccccagag cacttccctc tgcgcaagac agtctctgag    780

cccaacctga agctgcgcta taagcccaag aagtccctgg agcggaggaa gaatccactg    840

ctccgaaagg agagtgcgcc ccccagcctc cggcggcggc ccgcagagac cctcggagac    900

tcctccccaa gtagtagcag cacgcccgca tcagggtgca gctcccccaa tgacagcgag    960

cacggcccca atcccatcct gggctcggag gctgacagtg accgcaggac ccatccgact   1020

ctgggccctc gggggccaat cctggggagc ccccacactc ccctcttcct gccccatggc   1080

ttggagcccg aggctggggg caccttgccc tctcgcctgc agcccattct cctcctggac   1140

ccctcaggct ctcatgcccc gctgctgact gtgcccgggc ttgggccctt gcccttccac   1200

tttgcccagt ccttaatgac caccgagcgg ctctctgggt caggcctcca ctggccactg   1260

agccggactc gctcagagcc cctgcccccc agtgccaccg ctcccccacc gccgggcccc   1320

atgcagcccc gcctggagca gctcaaaact cacgtccagg tgatcaagag gtcagccaag   1380

ccgagtgaga agccccggct gcggcagata ccctcggctg aagacctgga gacagatggc   1440

gggggaccgg gccaggtggt ggacgatggc ctggagcaca gggagctggg ccatgggcag   1500

cctgaggcca gaggccccgc tcctctccag cagcaccctc aggtgttgct ctgggaacag   1560

cagcgactgg ctgggcggct cccccggggc agcaccgggg acactgtgct gcttcctctg   1620

gcccagggtg ggcaccggcc tctgtcccgg gctcagtctt ccccagccgc acctgcctca   1680

ctgtcagccc cagagcctgc cagccaggcc cgagtcctct ccagctcaga gacccctgcc   1740

aggaccctgc ccttcaccac agggctgatc tatgactcgg tcatgctgaa gcaccagtgc   1800

tcctgcggtg acaacagcag gcacccggag cacgccggcc gcatccagag catctggtcc   1860

cggctgcagg agcgggggct ccggagccag tgtgagtgtc tccgaggccg gaaggcctcc   1920

ctggaagagc tgcagtcggt ccactctgag cggcacgtgc tcctctacgg caccaacccg   1980

ctcagccgcc tcaaactgga caacgggaag ctggcagggc tcctggcaca gcggatgttt   2040

gtgatgctgc cctgtggtgg ggttggggtg gacactgaca ccatctggaa tgagcttcat   2100

tcctccaatg cagcccgctg ggccgctggc agtgtcactg acctcgcctt caaagtggct   2160

tctcgtgagc taaagaatgg tttcgctgtg gtgcggcccc caggacacca tgcagatcat   2220

tcaacagcca tgggcttctg cttcttcaac tcagtggcca tcgcctgccg gcagctgcaa   2280

cagcagagca aggccagcaa gatcctcatt gtagactggg acgtgcacca tggcaacggc   2340

acccagcaaa ccttctacca agaccccagt gtgctctaca tctccctgca tcgccatgac   2400

gacggcaact tcttcccggg gagtggggct gtggatgagg taggggctgg cagcggtgag   2460

ggcttcaatg tcaatgtggc ctgggctgga ggtctggacc cccccatggg ggatcctgag   2520

tacctggctg ctttcaggat agtcgtgatg cccatcgccc gagagttctc tccagaccta   2580

gtcctggtgt ctgctggatt tgatgctgct gagggtcacc cggccccact gggtggctac   2640

catgtttctg ccaaatgttt tggatacatg acgcagcaac tgatgaacct ggcaggaggc   2700

gcagtggtgc tggccttgga gggtggccat gacctcacag ccatctgtga cgcctctgag   2760

gcctgtgtgg ctgctcttct gggtaacagg gtggatcccc tttcagaaga aggctggaaa   2820

cagaaaccca acctcaatgc catccgctct ctggaggccg tgatccgggt gcacagtaaa   2880

tactggggct gcatgcagcg cctggcctcc tgtccagact cctgggtgcc tagagtgcca   2940

ggggctgaca aagaagaagt ggaggcagtg accgcactgg cgtccctctc tgtgggcatc   3000

ctggctgaag ataggccctc ggagcagctg gtggaggagg aagaacctat gaatctctaa   3060

ggctctggaa ccatctgccc gcccaccatg cccttgggac ctggttctct tctaacccct   3120

ggcaatagcc cccattcctg ggtctttaga gatcctgtgg gcaagtagtt ggaaccagag   3180

aacagcctgc ctgctttgac agttatccca gggagcgtga gaaaatccct gggtctagaa   3240

tgggaactgg agaggaccct gagaggagac gggctgggcg gcgaccccca cagggctctc   3300

gagaacagat tctcccctcc agtatgggcc ctggctgtgg cccccattcc tcaggactgc   3360

acagaggagg actggctccg gctccgtcgg gctcaccctt aaccactatt cctggctctg   3420

caaaccccag actttgcaca cagcctcagg ctccacacag aaatgtgaac ttggcctcag   3480

acaggctggc ccttcctagg ctctaggggc taggggggag tggggagcca agaggtccca   3540

tattcctgag tgcaggggta gtccctctca cctgcttcct cagacgactc tggaagcttc   3600

cctctaccac tgggcactga gacgaagctc cctgacagcc gagactggca gccctccatc   3660

tggtccgtac cctcgccaga ggccccccta catcaacctc ctggcgatgc cctggtggag   3720

cagatgggtg ctctgggagt cctgtgcttc ctgatccaat ggtgccaaac ccttcatctc   3780

cccaagaagc gcagcatacc cctgggaccc ctcggccact gcccactcgg ggagccttct   3840

ctgtttctgg ggcctccccc accatagctc tgattcccac cccacatagg agtagcctga   3900

ctgaggggga aggggtggga gagaagatac agacatggag gaggggaggc tgctctggca   3960

aagtcttcaa ggcttttggg ggtccaggcc tggggtcaag aaggaaaatg tgtgtgagca   4020

tgtgtgtgag tgaggcgtgt gtgtgagcgt gtgtgtgagt gaggcgtgtg tgtgtgtctt   4080

tcctaggacc caccataccc tgtgtatgta tgcatgtttt tgtaaaaagg aagaaaatgg   4140

aaaaaaatct gaacaataaa tgttttattt gctttaaaaa aaaaaaaaaa              4190


<210>  434
<211>  954
<212>  PRT
<213>  Homo sapiens

<400>  434


Met His Ser Pro Gly Ala Asp Gly Thr Gln Val Ser Pro Gly Ala His 
1               5                   10                  15      


Tyr Cys Ser Pro Thr Gly Ala Gly Cys Pro Arg Pro Cys Ala Asp Thr 
            20                  25                  30          


Pro Gly Pro Gln Pro Gln Pro Met Asp Leu Arg Val Gly Gln Arg Pro 
        35                  40                  45              


Pro Val Glu Pro Pro Pro Glu Pro Thr Leu Leu Ala Leu Gln Arg Pro 
    50                  55                  60                  


Gln Arg Leu His His His Leu Phe Leu Ala Gly Leu Gln Gln Gln Arg 
65                  70                  75                  80  


Ser Val Glu Pro Met Arg Leu Ser Met Asp Thr Pro Met Pro Glu Leu 
                85                  90                  95      


Gln Val Gly Pro Gln Glu Gln Glu Leu Arg Gln Leu Leu His Lys Asp 
            100                 105                 110         


Lys Ser Lys Arg Ser Ala Val Ala Ser Ser Val Val Lys Gln Lys Leu 
        115                 120                 125             


Ala Glu Val Ile Leu Lys Lys Gln Gln Ala Ala Leu Glu Arg Thr Val 
    130                 135                 140                 


His Pro Asn Ser Pro Gly Ile Pro Tyr Arg Thr Leu Glu Pro Leu Glu 
145                 150                 155                 160 


Thr Glu Gly Ala Thr Arg Ser Met Leu Ser Ser Phe Leu Pro Pro Val 
                165                 170                 175     


Pro Ser Leu Pro Ser Asp Pro Pro Glu His Phe Pro Leu Arg Lys Thr 
            180                 185                 190         


Val Ser Glu Pro Asn Leu Lys Leu Arg Tyr Lys Pro Lys Lys Ser Leu 
        195                 200                 205             


Glu Arg Arg Lys Asn Pro Leu Leu Arg Lys Glu Ser Ala Pro Pro Ser 
    210                 215                 220                 


Leu Arg Arg Arg Pro Ala Glu Thr Leu Gly Asp Ser Ser Pro Ser Ser 
225                 230                 235                 240 


Ser Ser Thr Pro Ala Ser Gly Cys Ser Ser Pro Asn Asp Ser Glu His 
                245                 250                 255     


Gly Pro Asn Pro Ile Leu Gly Ser Glu Ala Asp Ser Asp Arg Arg Thr 
            260                 265                 270         


His Pro Thr Leu Gly Pro Arg Gly Pro Ile Leu Gly Ser Pro His Thr 
        275                 280                 285             


Pro Leu Phe Leu Pro His Gly Leu Glu Pro Glu Ala Gly Gly Thr Leu 
    290                 295                 300                 


Pro Ser Arg Leu Gln Pro Ile Leu Leu Leu Asp Pro Ser Gly Ser His 
305                 310                 315                 320 


Ala Pro Leu Leu Thr Val Pro Gly Leu Gly Pro Leu Pro Phe His Phe 
                325                 330                 335     


Ala Gln Ser Leu Met Thr Thr Glu Arg Leu Ser Gly Ser Gly Leu His 
            340                 345                 350         


Trp Pro Leu Ser Arg Thr Arg Ser Glu Pro Leu Pro Pro Ser Ala Thr 
        355                 360                 365             


Ala Pro Pro Pro Pro Gly Pro Met Gln Pro Arg Leu Glu Gln Leu Lys 
    370                 375                 380                 


Thr His Val Gln Val Ile Lys Arg Ser Ala Lys Pro Ser Glu Lys Pro 
385                 390                 395                 400 


Arg Leu Arg Gln Ile Pro Ser Ala Glu Asp Leu Glu Thr Asp Gly Gly 
                405                 410                 415     


Gly Pro Gly Gln Val Val Asp Asp Gly Leu Glu His Arg Glu Leu Gly 
            420                 425                 430         


His Gly Gln Pro Glu Ala Arg Gly Pro Ala Pro Leu Gln Gln His Pro 
        435                 440                 445             


Gln Val Leu Leu Trp Glu Gln Gln Arg Leu Ala Gly Arg Leu Pro Arg 
    450                 455                 460                 


Gly Ser Thr Gly Asp Thr Val Leu Leu Pro Leu Ala Gln Gly Gly His 
465                 470                 475                 480 


Arg Pro Leu Ser Arg Ala Gln Ser Ser Pro Ala Ala Pro Ala Ser Leu 
                485                 490                 495     


Ser Ala Pro Glu Pro Ala Ser Gln Ala Arg Val Leu Ser Ser Ser Glu 
            500                 505                 510         


Thr Pro Ala Arg Thr Leu Pro Phe Thr Thr Gly Leu Ile Tyr Asp Ser 
        515                 520                 525             


Val Met Leu Lys His Gln Cys Ser Cys Gly Asp Asn Ser Arg His Pro 
    530                 535                 540                 


Glu His Ala Gly Arg Ile Gln Ser Ile Trp Ser Arg Leu Gln Glu Arg 
545                 550                 555                 560 


Gly Leu Arg Ser Gln Cys Glu Cys Leu Arg Gly Arg Lys Ala Ser Leu 
                565                 570                 575     


Glu Glu Leu Gln Ser Val His Ser Glu Arg His Val Leu Leu Tyr Gly 
            580                 585                 590         


Thr Asn Pro Leu Ser Arg Leu Lys Leu Asp Asn Gly Lys Leu Ala Gly 
        595                 600                 605             


Leu Leu Ala Gln Arg Met Phe Val Met Leu Pro Cys Gly Gly Val Gly 
    610                 615                 620                 


Val Asp Thr Asp Thr Ile Trp Asn Glu Leu His Ser Ser Asn Ala Ala 
625                 630                 635                 640 


Arg Trp Ala Ala Gly Ser Val Thr Asp Leu Ala Phe Lys Val Ala Ser 
                645                 650                 655     


Arg Glu Leu Lys Asn Gly Phe Ala Val Val Arg Pro Pro Gly His His 
            660                 665                 670         


Ala Asp His Ser Thr Ala Met Gly Phe Cys Phe Phe Asn Ser Val Ala 
        675                 680                 685             


Ile Ala Cys Arg Gln Leu Gln Gln Gln Ser Lys Ala Ser Lys Ile Leu 
    690                 695                 700                 


Ile Val Asp Trp Asp Val His His Gly Asn Gly Thr Gln Gln Thr Phe 
705                 710                 715                 720 


Tyr Gln Asp Pro Ser Val Leu Tyr Ile Ser Leu His Arg His Asp Asp 
                725                 730                 735     


Gly Asn Phe Phe Pro Gly Ser Gly Ala Val Asp Glu Val Gly Ala Gly 
            740                 745                 750         


Ser Gly Glu Gly Phe Asn Val Asn Val Ala Trp Ala Gly Gly Leu Asp 
        755                 760                 765             


Pro Pro Met Gly Asp Pro Glu Tyr Leu Ala Ala Phe Arg Ile Val Val 
    770                 775                 780                 


Met Pro Ile Ala Arg Glu Phe Ser Pro Asp Leu Val Leu Val Ser Ala 
785                 790                 795                 800 


Gly Phe Asp Ala Ala Glu Gly His Pro Ala Pro Leu Gly Gly Tyr His 
                805                 810                 815     


Val Ser Ala Lys Cys Phe Gly Tyr Met Thr Gln Gln Leu Met Asn Leu 
            820                 825                 830         


Ala Gly Gly Ala Val Val Leu Ala Leu Glu Gly Gly His Asp Leu Thr 
        835                 840                 845             


Ala Ile Cys Asp Ala Ser Glu Ala Cys Val Ala Ala Leu Leu Gly Asn 
    850                 855                 860                 


Arg Val Asp Pro Leu Ser Glu Glu Gly Trp Lys Gln Lys Pro Asn Leu 
865                 870                 875                 880 


Asn Ala Ile Arg Ser Leu Glu Ala Val Ile Arg Val His Ser Lys Tyr 
                885                 890                 895     


Trp Gly Cys Met Gln Arg Leu Ala Ser Cys Pro Asp Ser Trp Val Pro 
            900                 905                 910         


Arg Val Pro Gly Ala Asp Lys Glu Glu Val Glu Ala Val Thr Ala Leu 
        915                 920                 925             


Ala Ser Leu Ser Val Gly Ile Leu Ala Glu Asp Arg Pro Ser Glu Gln 
    930                 935                 940                 


Leu Val Glu Glu Glu Glu Pro Met Asn Leu 
945                 950                 

<210>  435
<211>  4301
<212>  DNA
<213>  Homo sapiens

<400>  435
agataaagca tttccttcca ttgtcatcct acccggccgg ccgggctgcc agggccctcc     60

ccctcccggc cccctccctt cctctcgccg tctcacagtc gctctgcagc ctccggcgac    120

tggggggatg tgaggccggc gccccagccc cccgccccgc catgagcccc ccgctctgag    180

ggccccggcc cctggatgca cagccccggc gctgatggga cccaggtgag cccgggtgcc    240

cactactgca gccccactgg cgcaggctgc cccaggccct gtgcagacac accaggccct    300

cagccgcagc ccatggacct gcgggtgggc cagcggcccc cagtggagcc cccaccagag    360

cccacattgc tggccctgca gcgtccccag cgcctgcacc accacctctt cctagcaggc    420

ctgcagcagc agcgctcggt ggagcccatg aggctctcca tggacacgcc gatgcccgag    480

ttgcaggtgg gaccccagga acaagagctg cggcagcttc tccacaagga caagagcaag    540

cgaagtgctg tagccagcag cgtggtcaag cagaagctag cggaggtgat tctgaaaaaa    600

cagcaggcgg ccctagaaag aacagtccat cccaacagcc ccggcattcc ctacagaacc    660

ctggagcccc tggagacgga aggagccacc cgctccatgc tcagcagctt tttgcctcct    720

gttcccagcc tgcccagtga ccccccagag cacttccctc tgcgcaagac agtctctgag    780

cccaacctga agctgcgcta taagcccaag aagtccctgg agcggaggaa gaatccactg    840

ctccgaaagg agagtgcgcc ccccagcctc cggcggcggc ccgcagagac cctcggagac    900

tcctccccaa gtagtagcag cacgcccgca tcagggtgca gctcccccaa tgacagcgag    960

cacggcccca atcccatcct gggctcggag gcgctcttgg gccagcggct gcggctgcag   1020

gagacttctg tggccccgtt cgccttgccg acagtgtcct tgctgcccgc aatcactctg   1080

gggctgcccg cccctgccag ggctgacagt gaccgcagga cccatccgac tctgggccct   1140

cgggggccaa tcctggggag cccccacact cccctcttcc tgccccatgg cttggagccc   1200

gaggctgggg gcaccttgcc ctctcgcctg cagcccattc tcctcctgga cccctcaggc   1260

tctcatgccc cgctgctgac tgtgcccggg cttgggccct tgcccttcca ctttgcccag   1320

tccttaatga ccaccgagcg gctctctggg tcaggcctcc actggccact gagccggact   1380

cgctcagagc ccctgccccc cagtgccacc gctcccccac cgccgggccc catgcagccc   1440

cgcctggagc agctcaaaac tcacgtccag gtgatcaaga ggtcagccaa gccgagtgag   1500

aagccccggc tgcggcagat accctcggct gaagacctgg agacagatgg cgggggaccg   1560

ggccaggtgg tggacgatgg cctggagcac agggagctgg gccatgggca gcctgaggcc   1620

agaggccccg ctcctctcca gcagcaccct caggtgttgc tctgggaaca gcagcgactg   1680

gctgggcggc tcccccgggg cagcaccggg gacactgtgc tgcttcctct ggcccagggt   1740

gggcaccggc ctctgtcccg ggctcagtct tccccagccg cacctgcctc actgtcagcc   1800

ccagagcctg ccagccaggc ccgagtcctc tccagctcag agacccctgc caggaccctg   1860

cccttcacca cagggctgat ctatgactcg gtcatgctga agcaccagtg ctcctgcggt   1920

gacaacagca ggcacccgga gcacgccggc cgcatccaga gcatctggtc ccggctgcag   1980

gagcgggggc tccggagcca gtgtgagtgt ctccgaggcc ggaaggcctc cctggaagag   2040

ctgcagtcgg tccactctga gcggcacgtg ctcctctacg gcaccaaccc gctcagccgc   2100

ctcaaactgg acaacgggaa gctggcaggg ctcctggcac agcggatgtt tgtgatgctg   2160

ccctgtggtg gggttggggt ggacactgac accatctgga atgagcttca ttcctccaat   2220

gcagcccgct gggccgctgg cagtgtcact gacctcgcct tcaaagtggc ttctcgtgag   2280

ctaaagaatg gtttcgctgt ggtgcggccc ccaggacacc atgcagatca ttcaacagcc   2340

atgggcttct gcttcttcaa ctcagtggcc atcgcctgcc ggcagctgca acagcagagc   2400

aaggccagca agatcctcat tgtagactgg gacgtgcacc atggcaacgg cacccagcaa   2460

accttctacc aagaccccag tgtgctctac atctccctgc atcgccatga cgacggcaac   2520

ttcttcccgg ggagtggggc tgtggatgag gtaggggctg gcagcggtga gggcttcaat   2580

gtcaatgtgg cctgggctgg aggtctggac ccccccatgg gggatcctga gtacctggct   2640

gctttcagga tagtcgtgat gcccatcgcc cgagagttct ctccagacct agtcctggtg   2700

tctgctggat ttgatgctgc tgagggtcac ccggccccac tgggtggcta ccatgtttct   2760

gccaaatgtt ttggatacat gacgcagcaa ctgatgaacc tggcaggagg cgcagtggtg   2820

ctggccttgg agggtggcca tgacctcaca gccatctgtg acgcctctga ggcctgtgtg   2880

gctgctcttc tgggtaacag ggtggatccc ctttcagaag aaggctggaa acagaaaccc   2940

aacctcaatg ccatccgctc tctggaggcc gtgatccggg tgcacagtaa atactggggc   3000

tgcatgcagc gcctggcctc ctgtccagac tcctgggtgc ctagagtgcc aggggctgac   3060

aaagaagaag tggaggcagt gaccgcactg gcgtccctct ctgtgggcat cctggctgaa   3120

gataggccct cggagcagct ggtggaggag gaagaaccta tgaatctcta aggctctgga   3180

accatctgcc cgcccaccat gcccttggga cctggttctc ttctaacccc tggcaatagc   3240

ccccattcct gggtctttag agatcctgtg ggcaagtagt tggaaccaga gaacagcctg   3300

cctgctttga cagttatccc agggagcgtg agaaaatccc tgggtctaga atgggaactg   3360

gagaggaccc tgagaggaga cgggctgggc ggcgaccccc acagggctct cgagaacaga   3420

ttctcccctc cagtatgggc cctggctgtg gcccccattc ctcaggactg cacagaggag   3480

gactggctcc ggctccgtcg ggctcaccct taaccactat tcctggctct gcaaacccca   3540

gactttgcac acagcctcag gctccacaca gaaatgtgaa cttggcctca gacaggctgg   3600

cccttcctag gctctagggg ctagggggga gtggggagcc aagaggtccc atattcctga   3660

gtgcaggggt agtccctctc acctgcttcc tcagacgact ctggaagctt ccctctacca   3720

ctgggcactg agacgaagct ccctgacagc cgagactggc agccctccat ctggtccgta   3780

ccctcgccag aggcccccct acatcaacct cctggcgatg ccctggtgga gcagatgggt   3840

gctctgggag tcctgtgctt cctgatccaa tggtgccaaa cccttcatct ccccaagaag   3900

cgcagcatac ccctgggacc cctcggccac tgcccactcg gggagccttc tctgtttctg   3960

gggcctcccc caccatagct ctgattccca ccccacatag gagtagcctg actgaggggg   4020

aaggggtggg agagaagata cagacatgga ggaggggagg ctgctctggc aaagtcttca   4080

aggcttttgg gggtccaggc ctggggtcaa gaaggaaaat gtgtgtgagc atgtgtgtga   4140

gtgaggcgtg tgtgtgagcg tgtgtgtgag tgaggcgtgt gtgtgtgtct ttcctaggac   4200

ccaccatacc ctgtgtatgt atgcatgttt ttgtaaaaag gaagaaaatg gaaaaaaatc   4260

tgaacaataa atgttttatt tgctttaaaa aaaaaaaaaa a                       4301


<210>  436
<211>  991
<212>  PRT
<213>  Homo sapiens

<400>  436


Met His Ser Pro Gly Ala Asp Gly Thr Gln Val Ser Pro Gly Ala His 
1               5                   10                  15      


Tyr Cys Ser Pro Thr Gly Ala Gly Cys Pro Arg Pro Cys Ala Asp Thr 
            20                  25                  30          


Pro Gly Pro Gln Pro Gln Pro Met Asp Leu Arg Val Gly Gln Arg Pro 
        35                  40                  45              


Pro Val Glu Pro Pro Pro Glu Pro Thr Leu Leu Ala Leu Gln Arg Pro 
    50                  55                  60                  


Gln Arg Leu His His His Leu Phe Leu Ala Gly Leu Gln Gln Gln Arg 
65                  70                  75                  80  


Ser Val Glu Pro Met Arg Leu Ser Met Asp Thr Pro Met Pro Glu Leu 
                85                  90                  95      


Gln Val Gly Pro Gln Glu Gln Glu Leu Arg Gln Leu Leu His Lys Asp 
            100                 105                 110         


Lys Ser Lys Arg Ser Ala Val Ala Ser Ser Val Val Lys Gln Lys Leu 
        115                 120                 125             


Ala Glu Val Ile Leu Lys Lys Gln Gln Ala Ala Leu Glu Arg Thr Val 
    130                 135                 140                 


His Pro Asn Ser Pro Gly Ile Pro Tyr Arg Thr Leu Glu Pro Leu Glu 
145                 150                 155                 160 


Thr Glu Gly Ala Thr Arg Ser Met Leu Ser Ser Phe Leu Pro Pro Val 
                165                 170                 175     


Pro Ser Leu Pro Ser Asp Pro Pro Glu His Phe Pro Leu Arg Lys Thr 
            180                 185                 190         


Val Ser Glu Pro Asn Leu Lys Leu Arg Tyr Lys Pro Lys Lys Ser Leu 
        195                 200                 205             


Glu Arg Arg Lys Asn Pro Leu Leu Arg Lys Glu Ser Ala Pro Pro Ser 
    210                 215                 220                 


Leu Arg Arg Arg Pro Ala Glu Thr Leu Gly Asp Ser Ser Pro Ser Ser 
225                 230                 235                 240 


Ser Ser Thr Pro Ala Ser Gly Cys Ser Ser Pro Asn Asp Ser Glu His 
                245                 250                 255     


Gly Pro Asn Pro Ile Leu Gly Ser Glu Ala Leu Leu Gly Gln Arg Leu 
            260                 265                 270         


Arg Leu Gln Glu Thr Ser Val Ala Pro Phe Ala Leu Pro Thr Val Ser 
        275                 280                 285             


Leu Leu Pro Ala Ile Thr Leu Gly Leu Pro Ala Pro Ala Arg Ala Asp 
    290                 295                 300                 


Ser Asp Arg Arg Thr His Pro Thr Leu Gly Pro Arg Gly Pro Ile Leu 
305                 310                 315                 320 


Gly Ser Pro His Thr Pro Leu Phe Leu Pro His Gly Leu Glu Pro Glu 
                325                 330                 335     


Ala Gly Gly Thr Leu Pro Ser Arg Leu Gln Pro Ile Leu Leu Leu Asp 
            340                 345                 350         


Pro Ser Gly Ser His Ala Pro Leu Leu Thr Val Pro Gly Leu Gly Pro 
        355                 360                 365             


Leu Pro Phe His Phe Ala Gln Ser Leu Met Thr Thr Glu Arg Leu Ser 
    370                 375                 380                 


Gly Ser Gly Leu His Trp Pro Leu Ser Arg Thr Arg Ser Glu Pro Leu 
385                 390                 395                 400 


Pro Pro Ser Ala Thr Ala Pro Pro Pro Pro Gly Pro Met Gln Pro Arg 
                405                 410                 415     


Leu Glu Gln Leu Lys Thr His Val Gln Val Ile Lys Arg Ser Ala Lys 
            420                 425                 430         


Pro Ser Glu Lys Pro Arg Leu Arg Gln Ile Pro Ser Ala Glu Asp Leu 
        435                 440                 445             


Glu Thr Asp Gly Gly Gly Pro Gly Gln Val Val Asp Asp Gly Leu Glu 
    450                 455                 460                 


His Arg Glu Leu Gly His Gly Gln Pro Glu Ala Arg Gly Pro Ala Pro 
465                 470                 475                 480 


Leu Gln Gln His Pro Gln Val Leu Leu Trp Glu Gln Gln Arg Leu Ala 
                485                 490                 495     


Gly Arg Leu Pro Arg Gly Ser Thr Gly Asp Thr Val Leu Leu Pro Leu 
            500                 505                 510         


Ala Gln Gly Gly His Arg Pro Leu Ser Arg Ala Gln Ser Ser Pro Ala 
        515                 520                 525             


Ala Pro Ala Ser Leu Ser Ala Pro Glu Pro Ala Ser Gln Ala Arg Val 
    530                 535                 540                 


Leu Ser Ser Ser Glu Thr Pro Ala Arg Thr Leu Pro Phe Thr Thr Gly 
545                 550                 555                 560 


Leu Ile Tyr Asp Ser Val Met Leu Lys His Gln Cys Ser Cys Gly Asp 
                565                 570                 575     


Asn Ser Arg His Pro Glu His Ala Gly Arg Ile Gln Ser Ile Trp Ser 
            580                 585                 590         


Arg Leu Gln Glu Arg Gly Leu Arg Ser Gln Cys Glu Cys Leu Arg Gly 
        595                 600                 605             


Arg Lys Ala Ser Leu Glu Glu Leu Gln Ser Val His Ser Glu Arg His 
    610                 615                 620                 


Val Leu Leu Tyr Gly Thr Asn Pro Leu Ser Arg Leu Lys Leu Asp Asn 
625                 630                 635                 640 


Gly Lys Leu Ala Gly Leu Leu Ala Gln Arg Met Phe Val Met Leu Pro 
                645                 650                 655     


Cys Gly Gly Val Gly Val Asp Thr Asp Thr Ile Trp Asn Glu Leu His 
            660                 665                 670         


Ser Ser Asn Ala Ala Arg Trp Ala Ala Gly Ser Val Thr Asp Leu Ala 
        675                 680                 685             


Phe Lys Val Ala Ser Arg Glu Leu Lys Asn Gly Phe Ala Val Val Arg 
    690                 695                 700                 


Pro Pro Gly His His Ala Asp His Ser Thr Ala Met Gly Phe Cys Phe 
705                 710                 715                 720 


Phe Asn Ser Val Ala Ile Ala Cys Arg Gln Leu Gln Gln Gln Ser Lys 
                725                 730                 735     


Ala Ser Lys Ile Leu Ile Val Asp Trp Asp Val His His Gly Asn Gly 
            740                 745                 750         


Thr Gln Gln Thr Phe Tyr Gln Asp Pro Ser Val Leu Tyr Ile Ser Leu 
        755                 760                 765             


His Arg His Asp Asp Gly Asn Phe Phe Pro Gly Ser Gly Ala Val Asp 
    770                 775                 780                 


Glu Val Gly Ala Gly Ser Gly Glu Gly Phe Asn Val Asn Val Ala Trp 
785                 790                 795                 800 


Ala Gly Gly Leu Asp Pro Pro Met Gly Asp Pro Glu Tyr Leu Ala Ala 
                805                 810                 815     


Phe Arg Ile Val Val Met Pro Ile Ala Arg Glu Phe Ser Pro Asp Leu 
            820                 825                 830         


Val Leu Val Ser Ala Gly Phe Asp Ala Ala Glu Gly His Pro Ala Pro 
        835                 840                 845             


Leu Gly Gly Tyr His Val Ser Ala Lys Cys Phe Gly Tyr Met Thr Gln 
    850                 855                 860                 


Gln Leu Met Asn Leu Ala Gly Gly Ala Val Val Leu Ala Leu Glu Gly 
865                 870                 875                 880 


Gly His Asp Leu Thr Ala Ile Cys Asp Ala Ser Glu Ala Cys Val Ala 
                885                 890                 895     


Ala Leu Leu Gly Asn Arg Val Asp Pro Leu Ser Glu Glu Gly Trp Lys 
            900                 905                 910         


Gln Lys Pro Asn Leu Asn Ala Ile Arg Ser Leu Glu Ala Val Ile Arg 
        915                 920                 925             


Val His Ser Lys Tyr Trp Gly Cys Met Gln Arg Leu Ala Ser Cys Pro 
    930                 935                 940                 


Asp Ser Trp Val Pro Arg Val Pro Gly Ala Asp Lys Glu Glu Val Glu 
945                 950                 955                 960 


Ala Val Thr Ala Leu Ala Ser Leu Ser Val Gly Ile Leu Ala Glu Asp 
                965                 970                 975     


Arg Pro Ser Glu Gln Leu Val Glu Glu Glu Glu Pro Met Asn Leu 
            980                 985                 990     

<210>  437
<211>  555
<212>  DNA
<213>  Homo sapiens

<400>  437
aactcacaag cagaggtagg ggtatgttca acctgatcgt cctcaaagta atgccaatta     60

aaatgagaca aaggaaaaag cccaccgtga ggggtgatgg ccaggtgctc actgcagatt    120

ccctcccata tatgggaggc tcctggagct ccatagtctc ctctactact gctgaggagc    180

aggccatggc aggcgcctgt ggggacagcc cccagaggac agggctgact gcaggaggaa    240

cagagcatca cagtgagaag acagacaaat agccagcagt tccacagcga ctcaggggac    300

tgccagggtt caaatcctgc tcctgctaga tgccacttct gctgctcttc attgctgccc    360

tagacaaggc caggccctgc ggcgtgctgc gagccttcct tccgttatct ttaccagctc    420

tacatggtca ttcacagatg agaaagctga agatcagaga gctcacacat ttcccacaag    480

gttacacagt cagtaagaga cactatcagg attccaatga cctgctgtta aagttcatct    540

cttattcact cattg                                                     555


<210>  438
<211>  82
<212>  PRT
<213>  Homo sapiens

<400>  438


Met Phe Asn Leu Ile Val Leu Lys Val Met Pro Ile Lys Met Arg Gln 
1               5                   10                  15      


Arg Lys Lys Pro Thr Val Arg Gly Asp Gly Gln Val Leu Thr Ala Asp 
            20                  25                  30          


Ser Leu Pro Tyr Met Gly Gly Ser Trp Ser Ser Ile Val Ser Ser Thr 
        35                  40                  45              


Thr Ala Glu Glu Gln Ala Met Ala Gly Ala Cys Gly Asp Ser Pro Gln 
    50                  55                  60                  


Arg Thr Gly Leu Thr Ala Gly Gly Thr Glu His His Ser Glu Lys Thr 
65                  70                  75                  80  


Asp Lys 
        

<210>  439
<211>  7578
<212>  DNA
<213>  Homo sapiens

<400>  439
tacgggaaat gtttggtgca gcatccagaa tggacaccac tgctgtctgc accgggggag     60

tgacagagag tcgagggatt gtggatagcc tgcagaagtt ttcctcgctc cctgcttacc    120

tccccacgaa cttgcacatc tccaatgcag aggagtcctt tttccttaaa gaagccaacc    180

aagacctcac aaggaactcc agtctgcagg cccgggtgga gccattcttc atctaccgag    240

ccaggacacc ccctattatc aatgccagct atggcccatt ttcagtggag aagataatcc    300

cccaggagct cctgttgaca tctacagcct ttggaaacat ggacaaattt cccttcaact    360

ggaaattgaa atcccacatc cttgacagct ccatctactc caacagaccc aaagtgcaga    420

ccttgtttta tgtcactggc atgggctggg atgacagtga ccttacggaa gatctaccct    480

gtgtcaagat gtttgctttc cctgaggcca gggaagtggc agccagctgt cggctgcaag    540

gggccccagg gctgtgtgtg gctgagctgg agctgctgcc cgagtggttc agctcaggcc    600

tggacctgga accagaggag gagatcccag ccctgctcgg gggcaccacg atggagctct    660

tcttcacgct ctacccagct gacaaggctg gccagtgtcc tctggaggag gaaggcaagt    720

gggagaacaa tatccactcg ggcctggaga gcccccagca agcgtttcca gcccgagaga    780

ggattgggag tgtggtggtc tacccaaccc aagatgatct gaagtggtcc ctggtgagct    840

tggacgagaa tgtggtcatc tcggtacctc tgaatctagt ccgggaaggg gacacggcca    900

cctttttggt ctctctgacc agtagctctg tggcagacca gttcactctt agaattaagg    960

cggcagcagg tgtgaagata acggcagtga gagtcagcag tgaggaccaa tgggcagtcc   1020

aggaggaaat tgataatggc agcactcaga cgtcggccac cctcacctgc atgggccatc   1080

gcccggacac gcagagcagg gtaaatggat ccttctatga gatcttgcaa gtggactttg   1140

gaattgataa tagcagtgac ctggctgggg cccagcagat tacctggcag gtggagtacc   1200

cgattgagga ctccatgagt gagctggtcg tctccgagat cttcgtcagc cagacaacct   1260

tcgtgggcat cgtccctctt gccatggaca ccgaggtttt gaacactgcc attctcactg   1320

gaaagcctgt ttcagttcct gtcaaagtcg tgggggtcca ggaggatggt tctgtggtcg   1380

atgtgtctga gtctgtggaa tgcaagtctg ccgatgaaga tgtcattaag gtttccaaca   1440

actgtgattc catttttgtg aatgggaagg aaatgaagag caaagtggac acgattgtga   1500

acttcaccca ccagcacttc acctcccagt tcgaggtcac tgtctgggca cccaggctcc   1560

ccctgcagat tgagatctca gacaccgagc tgagccagat caagggctgg aggatcccgg   1620

ttgctgccaa cagaaggcct acccgggaaa gcgatgacga ggacgatgag gagaagaagg   1680

gacgaggctg ctccctgcag taccagcacg ccacagtgcg tgtcctcacc cagtttgtgg   1740

ccgagtcacc tgacttaggg cagctgacct acatgctggg ccccgactgg cagtttgaca   1800

tcactgacct tgtgaccgag ttcatgaagg tggaggagcc gaaaatcgct cagttacagg   1860

acggcaggac cctggctggt cgggagccgg gaataaccac ggtgcaggtc ctctcgccgt   1920

tgtctgactc catcctggct gagaagacgg tgattgtcct ggatgaccga gtcaccatcg   1980

cggagctggg agtgcagctc gtagctggca tgtctctctc cctgcagcca caccgagcag   2040

acaaaagggc catcgtctcc acagctgctg ccctggatgt tcttcagtcc ccacagcagg   2100

aagcaatagt aagttcttgg attttgttca gtgatggttc ggtgacacct ttagacattt   2160

acgatcctaa ggattattct gttactgtct catcattgga tgaaatggtg gtgtctgtcc   2220

aggcaaacct tgagtccaaa tggccaattg tggttgcaga gggtgaagga caagggcctt   2280

tgattaagtt agaaatgatg ataagtgaac cttgtcagaa gaccaagagg aagagtgttc   2340

ttgccgtggg taaaggaaat gtcaaggtca aattcgaacc aagtagtgat gagcaccaag   2400

gaggcagcaa tgatattgag ggcataaatc gggaatataa agaccacctc agtaattcca   2460

tagagcgcga aggaaaccag gagagagcag tccaggaatg gttccaccgt ggcacacctg   2520

ttggccaaga ggaaagtacc aacaaaagca caacccccca gtctcccatg gaagggaaga   2580

ataagttact caaaagtggt ggtccagatg cctttacaag cttccccact caagggaagt   2640

caccggaccc caataatcct agtgacctca cagtgacctc aagggggcta acggacttgg   2700

agattggcat gtatgccttg ctctgcgtct tctgtctggc cattctggtc ttcttgatca   2760

actgcgtggc gtttgcctgg aaatacagac acaaaaggtt tgctgtgagt gagcagggca   2820

acatccccca ttcccacgac tgggtctggc ttgggaatga agtggaactt ttggagaacc   2880

ctgttgacat tacactccca tcagaggagt gcacaaccat gatagacagg ggcctgcagt   2940

tcgaggagag gaacttcctt ctgaatggca gttcccagaa gacttttcat agtcaactac   3000

tcagaccctc tgactatgtc tatgagaaag aaattaaaaa tgaacctatg aattcttcgg   3060

gcccaaagag gaagagagtc aagttcactt cctacaccac catcctccca gaggacggcg   3120

gcccatacac caactccatc ctgtttgaca gcgatgataa catcaagtgg gtctgccaag   3180

atatggggct gggggattca caggacttta gagactatat ggaaagtctg caagaccaga   3240

tgtaaactcc tttcttatgt ttgtattcac ctttatgcct tctgtttttt gaatgctgga   3300

gcagtgagtt tgatcagcaa taggggatga tttaacaaag tttgatttgt ggaggtctgg   3360

tgggattcat ttctaagcag gtaaaagagg tttggagagc tatagaagct gggttttaag   3420

tttggaaatg cctctaaaac agccacatgt ggggactgga gaaattctaa gacaacagtt   3480

ttatggactg cctggtacga gctcagtgca aatgtattaa acctgacccc acagacattg   3540

ttagtcatct cgtgacaaat ggccatgtgg aattagaaaa gatttgggtg ttgatttttc   3600

tatttctaga ccttttaaag cacagtggac acttattgcc ccttggcctg agtttagaca   3660

tacatgaaag atgactgaat gtagctatcc tgatttgtca tgagcgctgc tcattatttt   3720

tatatacatt tgcacctgca cctgttcctt tgacctctgg aattcttttt gaaacatgaa   3780

gagaagaaat ttcagtcttt tccttgagct ctgtttgatt tacacatgag ttttcttccc   3840

tgggatttgc catgccatgt tatttcctgg gtctccatgc aggatgtcag gtttttccag   3900

ttttctgcac ttcatcatct agggatggta tccaagaagc ttattctcac tttgtttttt   3960

ccttcctttt gttgttgaac tttcttgtat aacactggga caaagggttt tacttaaaat   4020

gttaatatac agtgagggag ggccatctct ttactgtttt ctatgtgaag tttcaaacat   4080

ttggaaaaaa gttgtcaatc acaaacattt atttttattc tctgcttgtt gaaaactcat   4140

ggggaactcc tggagtgcat ttctgagggt aaaaaggccc caacatagct gtatttatac   4200

aagtgctttg tggccaacac aatttactat ccaaactgaa gtcttaaagt agaattgacc   4260

tacacagaaa ggaaattgcc taggcaatag atgcagatta cactttccat tttaccagaa   4320

caaaagtttt ttttttttta aataagtaga atgacagttc aagttagcaa tatatagaaa   4380

tccatccata caatgaccaa aataaataaa taaataaaac tcaatcatga ctttggcaga   4440

gataaaacat tgacaagggt gtgcatttgt ggagagaagc agtgggtttc cccccaaaat   4500

ccatacaaat aaatgactat tccagaactc aagaagcagc tattatagaa aaaaaaatta   4560

aaaaccacag ctattgaaaa attaaaacgg caagagaaaa aaagaaacaa ctcctgcata   4620

atgtttaaat aaaaatgtta ttttaatagc atcatgaatg gtcttaaggc aaaaatttca   4680

gattagcaaa atgtgatgac atatttatta agattgtatt attggaaatg tagacactgg   4740

actagtatgc ctcattatga gctttactga gccatttgca tctctaagaa atatgatttt   4800

aaaggcccaa agtaggaagg atctgcaggg ggtcacctga agcagtgccc tgactccaaa   4860

tggctgataa ctgagctaat ccaaggagag gcgttcagtt gttctcttat tatagatttc   4920

cttgggtggg aacatgacaa ccccgcctcc tctagccatg acgtggcagc caaaaagttc   4980

ttcctgtatc tctggcccac aggactgtag tgtgtttggg aacagtgctg aaattgcaag   5040

tgatgtaggc ctgacctcca gagcccagcg ttcagttagt tgtataaaat ggggcttagg   5100

aaccgaagct gatgaagttc caaaagtagt tcagtttgat gggataagga agcaaggaga   5160

gccaggcatt agctgcaaaa ggagcttgca gagagatggc tgacacttta tgggaagatt   5220

cctcagtcag ccaaaagctt ttcaaagagt ttggtgcaga ggtagctcag agccaaccat   5280

ccaggaccga agaaagctca tgtgctgatt gacacatagc tatccaggtg agtcggctcc   5340

ttctatgagg cttttcaatc gtctctccct ttggatctct ggcattccag aaagactggg   5400

aattcatttc tgaaaatgat gaacctccgc tgaaacgggg aggaaatctc ttacacacat   5460

acagcagggt cctgcccact ggtaaagtga gacgttgggt agggggtgta actggggagg   5520

aggtgaagga aattatccct gccatgggga gtgttattca ggaacataaa aattagagca   5580

ttccctctga tggcagtgct tgacggggtg cagggaacaa actggggagc gttcaaacat   5640

gccagtggtt tctcagcagg gctggaaact ggccacagtc ctgaagatgc ttcttgtgac   5700

aacttagagt cactgggagt cacacagctc ctgtgtagcc gcctttgctc ctctgtgtta   5760

aaacccagtc agttcaaaat aacaatcaaa tggaaggcca tgggggaagg gttccttcca   5820

ccatataacc cacacccaga tgtatataaa cgcatataca tacatatacc cgtgtgtgtg   5880

tgtgtgtgtg tgtgtgtgtg tgtgaatact gaagagccag acaacaaact atttagtaag   5940

aatcaacagt gactgtcaat tgttctcaga tttggcatgg atactatttc tcatgaaata   6000

atgtcattaa agtatttcct cctctaaata tttcctgaag atcataaacc atgggttata   6060

gcaccttgtt ttccagctag tcaatataca actattaggt gctgtgcccc aaaatatcta   6120

aaatgggggt aaagatataa actattaagc catgaaatct aattttctgg ggaccatgca   6180

tttgcctgga ttttccagga ttttatggct gatagaccca aattattagt cttgataaac   6240

aacctgaacc aaacatttat aaagtccctt cctctcccat gggaatggaa tgctcagact   6300

cctgctgagg gagacaccag caagcctctt gagaaggcac cagacagtga actctgtggt   6360

cacatgaagg gaggttcaga tgctagacga ccagcgtatg acctggaacc attgaggatt   6420

gcaaccgctg cctccagggt ccagatgtgc tgcagtagag ggcagagcac aggaatcaag   6480

aagcagctgc cacaccaaag aactgatgct taaacacaca ggtgtgttgc atttgagaga   6540

aggcaagaag aaaagacaat agaaggttac cctggaaaaa caacacctag caaacctcag   6600

aatactccat gtgtcccaag agaaggaata attgtctttc tagctgttat atattgcaca   6660

ctggccagga taaattccca gactataata atcctgacta tgtagacgga agtttctatt   6720

tataaagtca tgcaggggga aagttgatta atttttgtcc cattgccaca tctgtagact   6780

aagtaatttt taacttgcta acttttagaa tgtccacctt tgtgcatttt ggtagcattc   6840

ttgtttcatt attttagaaa ggggtcttcc cattactggg atgtcggggc cctgtcagag   6900

aactattatt aaggctctgt gagggaactg ttcagtctca cagcaaggac cacagagcgt   6960

ggtttcatct gaaccctaca agtcagggac accagtgtgt tttctactcg agttacctaa   7020

aaatggtctc aattttccat ttcattctct gtaaatgaca caatagatgg tttatagact   7080

cagcagccct caccttttat taaaattata tatgtgtgat gtaatgcata tcacctgtca   7140

tgtaaaggga cggtatggat ggtggaaaag ttatgctaaa atatggattg cagatatttt   7200

tgtatgtaat ataggcaata taatgaaaca ccgagttttt taaagtgaaa gcatgcaaaa   7260

tcgtagcttt taaatgtaca gacatcccac tcaaaaatat ctaaactgat agtgggaaaa   7320

acatttgaga cctagtaaca tcatgaaatg cactgaattt ggaattctgg cctagaaagg   7380

ctgtggctta tgttgggatt gatgatggaa tctgccagaa cattttcatc ttattcttct   7440

tgacttttgg atttttttct tttctttttt tctggaaata tttcggaaat aaagtgactt   7500

catttttcag cataaaagta tattctaacc acagggtaac acatcgtttt taacatgaaa   7560

ataaacattt aaacattc                                                 7578


<210>  440
<211>  1078
<212>  PRT
<213>  Homo sapiens

<400>  440


Met Phe Gly Ala Ala Ser Arg Met Asp Thr Thr Ala Val Cys Thr Gly 
1               5                   10                  15      


Gly Val Thr Glu Ser Arg Gly Ile Val Asp Ser Leu Gln Lys Phe Ser 
            20                  25                  30          


Ser Leu Pro Ala Tyr Leu Pro Thr Asn Leu His Ile Ser Asn Ala Glu 
        35                  40                  45              


Glu Ser Phe Phe Leu Lys Glu Ala Asn Gln Asp Leu Thr Arg Asn Ser 
    50                  55                  60                  


Ser Leu Gln Ala Arg Val Glu Pro Phe Phe Ile Tyr Arg Ala Arg Thr 
65                  70                  75                  80  


Pro Pro Ile Ile Asn Ala Ser Tyr Gly Pro Phe Ser Val Glu Lys Ile 
                85                  90                  95      


Ile Pro Gln Glu Leu Leu Leu Thr Ser Thr Ala Phe Gly Asn Met Asp 
            100                 105                 110         


Lys Phe Pro Phe Asn Trp Lys Leu Lys Ser His Ile Leu Asp Ser Ser 
        115                 120                 125             


Ile Tyr Ser Asn Arg Pro Lys Val Gln Thr Leu Phe Tyr Val Thr Gly 
    130                 135                 140                 


Met Gly Trp Asp Asp Ser Asp Leu Thr Glu Asp Leu Pro Cys Val Lys 
145                 150                 155                 160 


Met Phe Ala Phe Pro Glu Ala Arg Glu Val Ala Ala Ser Cys Arg Leu 
                165                 170                 175     


Gln Gly Ala Pro Gly Leu Cys Val Ala Glu Leu Glu Leu Leu Pro Glu 
            180                 185                 190         


Trp Phe Ser Ser Gly Leu Asp Leu Glu Pro Glu Glu Glu Ile Pro Ala 
        195                 200                 205             


Leu Leu Gly Gly Thr Thr Met Glu Leu Phe Phe Thr Leu Tyr Pro Ala 
    210                 215                 220                 


Asp Lys Ala Gly Gln Cys Pro Leu Glu Glu Glu Gly Lys Trp Glu Asn 
225                 230                 235                 240 


Asn Ile His Ser Gly Leu Glu Ser Pro Gln Gln Ala Phe Pro Ala Arg 
                245                 250                 255     


Glu Arg Ile Gly Ser Val Val Val Tyr Pro Thr Gln Asp Asp Leu Lys 
            260                 265                 270         


Trp Ser Leu Val Ser Leu Asp Glu Asn Val Val Ile Ser Val Pro Leu 
        275                 280                 285             


Asn Leu Val Arg Glu Gly Asp Thr Ala Thr Phe Leu Val Ser Leu Thr 
    290                 295                 300                 


Ser Ser Ser Val Ala Asp Gln Phe Thr Leu Arg Ile Lys Ala Ala Ala 
305                 310                 315                 320 


Gly Val Lys Ile Thr Ala Val Arg Val Ser Ser Glu Asp Gln Trp Ala 
                325                 330                 335     


Val Gln Glu Glu Ile Asp Asn Gly Ser Thr Gln Thr Ser Ala Thr Leu 
            340                 345                 350         


Thr Cys Met Gly His Arg Pro Asp Thr Gln Ser Arg Val Asn Gly Ser 
        355                 360                 365             


Phe Tyr Glu Ile Leu Gln Val Asp Phe Gly Ile Asp Asn Ser Ser Asp 
    370                 375                 380                 


Leu Ala Gly Ala Gln Gln Ile Thr Trp Gln Val Glu Tyr Pro Ile Glu 
385                 390                 395                 400 


Asp Ser Met Ser Glu Leu Val Val Ser Glu Ile Phe Val Ser Gln Thr 
                405                 410                 415     


Thr Phe Val Gly Ile Val Pro Leu Ala Met Asp Thr Glu Val Leu Asn 
            420                 425                 430         


Thr Ala Ile Leu Thr Gly Lys Pro Val Ser Val Pro Val Lys Val Val 
        435                 440                 445             


Gly Val Gln Glu Asp Gly Ser Val Val Asp Val Ser Glu Ser Val Glu 
    450                 455                 460                 


Cys Lys Ser Ala Asp Glu Asp Val Ile Lys Val Ser Asn Asn Cys Asp 
465                 470                 475                 480 


Ser Ile Phe Val Asn Gly Lys Glu Met Lys Ser Lys Val Asp Thr Ile 
                485                 490                 495     


Val Asn Phe Thr His Gln His Phe Thr Ser Gln Phe Glu Val Thr Val 
            500                 505                 510         


Trp Ala Pro Arg Leu Pro Leu Gln Ile Glu Ile Ser Asp Thr Glu Leu 
        515                 520                 525             


Ser Gln Ile Lys Gly Trp Arg Ile Pro Val Ala Ala Asn Arg Arg Pro 
    530                 535                 540                 


Thr Arg Glu Ser Asp Asp Glu Asp Asp Glu Glu Lys Lys Gly Arg Gly 
545                 550                 555                 560 


Cys Ser Leu Gln Tyr Gln His Ala Thr Val Arg Val Leu Thr Gln Phe 
                565                 570                 575     


Val Ala Glu Ser Pro Asp Leu Gly Gln Leu Thr Tyr Met Leu Gly Pro 
            580                 585                 590         


Asp Trp Gln Phe Asp Ile Thr Asp Leu Val Thr Glu Phe Met Lys Val 
        595                 600                 605             


Glu Glu Pro Lys Ile Ala Gln Leu Gln Asp Gly Arg Thr Leu Ala Gly 
    610                 615                 620                 


Arg Glu Pro Gly Ile Thr Thr Val Gln Val Leu Ser Pro Leu Ser Asp 
625                 630                 635                 640 


Ser Ile Leu Ala Glu Lys Thr Val Ile Val Leu Asp Asp Arg Val Thr 
                645                 650                 655     


Ile Ala Glu Leu Gly Val Gln Leu Val Ala Gly Met Ser Leu Ser Leu 
            660                 665                 670         


Gln Pro His Arg Ala Asp Lys Arg Ala Ile Val Ser Thr Ala Ala Ala 
        675                 680                 685             


Leu Asp Val Leu Gln Ser Pro Gln Gln Glu Ala Ile Val Ser Ser Trp 
    690                 695                 700                 


Ile Leu Phe Ser Asp Gly Ser Val Thr Pro Leu Asp Ile Tyr Asp Pro 
705                 710                 715                 720 


Lys Asp Tyr Ser Val Thr Val Ser Ser Leu Asp Glu Met Val Val Ser 
                725                 730                 735     


Val Gln Ala Asn Leu Glu Ser Lys Trp Pro Ile Val Val Ala Glu Gly 
            740                 745                 750         


Glu Gly Gln Gly Pro Leu Ile Lys Leu Glu Met Met Ile Ser Glu Pro 
        755                 760                 765             


Cys Gln Lys Thr Lys Arg Lys Ser Val Leu Ala Val Gly Lys Gly Asn 
    770                 775                 780                 


Val Lys Val Lys Phe Glu Pro Ser Ser Asp Glu His Gln Gly Gly Ser 
785                 790                 795                 800 


Asn Asp Ile Glu Gly Ile Asn Arg Glu Tyr Lys Asp His Leu Ser Asn 
                805                 810                 815     


Ser Ile Glu Arg Glu Gly Asn Gln Glu Arg Ala Val Gln Glu Trp Phe 
            820                 825                 830         


His Arg Gly Thr Pro Val Gly Gln Glu Glu Ser Thr Asn Lys Ser Thr 
        835                 840                 845             


Thr Pro Gln Ser Pro Met Glu Gly Lys Asn Lys Leu Leu Lys Ser Gly 
    850                 855                 860                 


Gly Pro Asp Ala Phe Thr Ser Phe Pro Thr Gln Gly Lys Ser Pro Asp 
865                 870                 875                 880 


Pro Asn Asn Pro Ser Asp Leu Thr Val Thr Ser Arg Gly Leu Thr Asp 
                885                 890                 895     


Leu Glu Ile Gly Met Tyr Ala Leu Leu Cys Val Phe Cys Leu Ala Ile 
            900                 905                 910         


Leu Val Phe Leu Ile Asn Cys Val Ala Phe Ala Trp Lys Tyr Arg His 
        915                 920                 925             


Lys Arg Phe Ala Val Ser Glu Gln Gly Asn Ile Pro His Ser His Asp 
    930                 935                 940                 


Trp Val Trp Leu Gly Asn Glu Val Glu Leu Leu Glu Asn Pro Val Asp 
945                 950                 955                 960 


Ile Thr Leu Pro Ser Glu Glu Cys Thr Thr Met Ile Asp Arg Gly Leu 
                965                 970                 975     


Gln Phe Glu Glu Arg Asn Phe Leu Leu Asn Gly Ser Ser Gln Lys Thr 
            980                 985                 990         


Phe His Ser Gln Leu Leu Arg Pro  Ser Asp Tyr Val Tyr  Glu Lys Glu 
        995                 1000                 1005             


Ile Lys  Asn Glu Pro Met Asn  Ser Ser Gly Pro Lys  Arg Lys Arg 
    1010                 1015                 1020             


Val Lys  Phe Thr Ser Tyr Thr  Thr Ile Leu Pro Glu  Asp Gly Gly 
    1025                 1030                 1035             


Pro Tyr  Thr Asn Ser Ile Leu  Phe Asp Ser Asp Asp  Asn Ile Lys 
    1040                 1045                 1050             


Trp Val  Cys Gln Asp Met Gly  Leu Gly Asp Ser Gln  Asp Phe Arg 
    1055                 1060                 1065             


Asp Tyr  Met Glu Ser Leu Gln  Asp Gln Met 
    1070                 1075             

<210>  441
<211>  9919
<212>  DNA
<213>  Homo sapiens

<400>  441
gcttgcttgc ccggctcgct cacgggtcgt tgaggccggt gacatgtctg tgagctgcgg     60

aggctgcggc ccccagatct ttctctttga cactttgcaa taaaaaaggg cagtgagatt    120

gaataggtgt tttgtggatt aactcttcat tgattatata caacaaaaaa tagttatggc    180

gactttcaga aacaatcaca tgaagactaa agcatctgtc agaaaaagct tcagtgaaga    240

tgtgttccag tctgtaaagt ctttattgca gagtcagaag gaactatgca gtgtaacagc    300

agaggactgt ttacagcagg atgagcatgc caatttaact gaggtcacat ttctgggttt    360

taatgaagag acagatgctg ctcatataca ggatttagct gcagtttctt tggaacttcc    420

agatattctg aattcactcc acttctgcag tctaaatgaa aatgaaatta tttgtatgaa    480

gaatataaat aaaccattag atataagcag tgatcctcta aatcagagtc atccttctgg    540

aatgctttgt gtcatgagag tgtcacctac atcaccaaga cttaggattg attttatctt    600

tagtctccta agtaaatatg ctactggtat aaggtacacc ttggacacat tcttgcatca    660

gaagcaccaa cttgagacca ctgatgaaga tgatgatgat actaaccagt ctgtgtcatc    720

catagaggat gactttgtca ctgcttttga gcacttagaa gaggaagaga cttcaaagcc    780

atacaatgat ggaatgaaca ttactgtgct aaggagccag tgtgatgctg cttcccagac    840

ggttactggt catcatttag aaacccatga tttaaagatt ctcattagct ctggacagca    900

gaagtcattg gctaaaccct caacttcctc agtgaatgtc ctgggacata aagaactacc    960

ttctgtgaaa acttcagtca caacatcaat ttcagagcct tggacccaaa ggagtttcta   1020

taggtcatct aatgcttcag ataaagatag tgatttacag aaaacatttt tttcgtcttc   1080

tcctgcctac tcatctgaat cagaatgttc aagtccaagt cctgttattt tcttggatga   1140

agagggatat caaaaaagct taaaagcaaa acttgagctg cctaaaattc ctgtgatgaa   1200

agatgatata gaggattcag actcagaagt aagtgaattt tttgatagtt ttgatcagtt   1260

tgatgaacta gaacaaactt tagagacttg cctgtttaac aaagatcccg tcatagggaa   1320

gtcatcgcag aggaaagggc acaaacatgg aaagtcatgt atgaatcctc aaaaattcaa   1380

gtttgatcgt ccagctctcc cagctaatgt tagaaagcca actcctcgta aaccagaatc   1440

tccatatggt aacctgtgtg atgctccgga ttctcctcgc ccagtgaagg catcaaggga   1500

agatagtggt ttatttagtc ctattcgatc ctctgctttt agtcctcttg gaggctgtac   1560

tccagctgaa tgtttttgcc aaacagatat tggtggagat aggattcatg aaaatcatga   1620

ttctgtttat tacacctatg aagactatgc aaaaagcatt tcatgtgaag tactaggctc   1680

agttcttcgt acccaccata ctaataccct atcaaatatt aacagtatta aacatggaga   1740

aaataaaact gtaactttta agcatggaaa ccttgatcaa aaaaataaat ctaaaaataa   1800

atccttaatg attaaagata gcattcaaaa atttgcagca gatcttgtgg aaaaaagttt   1860

tggcagtgca tttaaagact tacagaaagg agtctcttca tgtaccaatg ctttgtacca   1920

cttagccatc aaattgacat catctgtttt gcagatggca tttgatgagc tgagaaggca   1980

gcgtgcattt tcactaaaag aacgtgccat tagtggcctg gctaactttt tggtgagtga   2040

agctttatca aatgccttaa aagatttaca gtatgtaaag aagcagatat tcacaaacac   2100

agttgctagg tttgctgcag atcttgctga agagcttgtt tttgaaggca tcatggaggt   2160

gtgtcagttt tcatatcctc aaacgcctgc atctccacag tgtgggtcgt ttgactttga   2220

agacaaagta gtgaagttgt atgcaaaaga tttgtctgaa tctgtaatac aggaagcatt   2280

cattgagcta tcacaagttg atgtgacctt tacaacaaag gcagcagtta gtgtctctac   2340

ggataatatc aagtatgtga gtgcagaaag tgtagtgcca tcgacacagg ctgtcacgtt   2400

ttccccttct tttcacaatc aagcaattat ggtgacaaaa ccagtgcagg aatataaaaa   2460

ggaatacaca gtgcagcagg ccttgttttg tacttctgga attgttactt ctataccggt   2520

gcccttggca ggaagtgccc ttctcccata tcatatttca tctactgcat gtcaggccaa   2580

ggctcatctg tcatctgatg atagtaattc aaatggtgat tctgcccaag tgcatattgc   2640

cacaaaaaac agagaagaaa aagcagcttg tctcagaaat atttgtttac cttcagaaca   2700

caatccaggt aatcagaatg attttaaacc aactaatgac gatattgaaa tgcagagttc   2760

ctcaaaatta ccaaatgatc ctgcaattat tagcaacttt tctgcagcag tggtgcatac   2820

gatagtaaat gaaactttag agtcaatgac atcattggaa gttacaaaaa tggttgatga   2880

acgtacagat tatttaacta aatctttaaa ggagaaaacc cctccatttt cccactgtga   2940

tcaggcagtg ctgcaatgca gtgaagctag tagcaataag gacatgtttg ctgaccggtt   3000

atctaaatct attattaaac attccataga taagagcaaa tcagtgatcc caaatataga   3060

taaaaatgca gtatacaagg aaagcttgcc tgtttctgga gaagaatcac agttgacacc   3120

agaaaagtct cccaaatttc ctgactctca gaatcagtta actcactgct cactttcagc   3180

tgcaaaggat tgtgttccag aatgtaaagt ttctatggtt catggatcct ccctagagac   3240

actgccatct tgtccagctg tgacaggtca gaaatctgac ttgaaggaat ctgctaagga   3300

tcaaccactg aaaaagcata acttgaatag tacatcactt gaggccttgt cttttggaca   3360

ggaaaacccc tttcctcatt cacatacttt ctcatctaca gcacttacct gtgtagatgg   3420

tttgcatgtg gaagataaac agaaagtcag agacagaaat gtaatacctg atactcctcc   3480

atcaactcct ctagtaccat cccgggctag ttctgaatgg gatatcaaga agttaactaa   3540

aaagctcaag ggagaattag ccaaagagtt tgcacctgct acaccacctt ctactccaca   3600

caactcatct gttggtagtt tgtctgagaa tgaacaaaat actatagaaa aagaagagtt   3660

catgttgaaa ctcatgcgat ctctttctga agaagttgag agtagtgaaa gtggagagct   3720

cccagaagtg gatgtgaagt cggagcactc agggaagaag gttcagtttg cagaagcatt   3780

agctacacac atcctttctc ttgcaactga aatggcagct tcccatttag ataacaaaat   3840

aattcaagaa cccaaggtta aaaacccttg cttaaatgtg caaagtcaaa gaagtgtgtc   3900

gcctactttt ttaaacccct cagacgaaaa tttgaaaaca ttatgcaatt ttgcgggtga   3960

tctggcagca gaagtcatta cagaagctga gaaaatagca aaagtccgaa attgtatgct   4020

tttcaagcaa aagaagaaca gttgttatgc tgatggtgac gaagattata aagtagaaga   4080

gaagttggat atagaggctg tagtgcaccc aagagaagtg gatccgttta ttctttcatt   4140

accaccaagt tcttgtatgt caggtctgat gtataagtat cccagctgtg aaagtgtgac   4200

agatgaatat gcaggtcacc ttattcagat actaaaacag gaaggtggta atagtgagtt   4260

gataatggat cagtatgcca ataggcttgc ctaccgatct gttaaatcag gattacagga   4320

agcagctaag acaaccaaag tgcagtgcaa ctcaagaatg ttccctgtgc caagttcaca   4380

agtgaaaaca aacaaggaac tgttaatgtt ttcaaacaaa gagcaccacc aagaagcaga   4440

caaaaagaga caaagtaaaa gaaatgaagg ttacttttgt aaaaatcaaa cttgtgaaag   4500

gaccctggat ccatatagaa atgaggtctc ccaactgtat agtttttcaa cctctctggt   4560

tcacagcata acaaaagatg ctaaggaaga gttgacagcc tctctagttg gcctaccaaa   4620

atccttaaca gattcttgct tgtttgaaaa atctggatat gaagaagata atgagtgtca   4680

cgttacacca gaattgccta agtctcttca gccttcctca caaaatcaca ggttttacca   4740

cagcactggc agtttaaatg gatatggttg tggagacaat gttgttcaag ctgtagaaca   4800

gtatgccaaa aaagtagtgg atgacactct agagctaact ctaggatcta cagtgttccg   4860

agtgtctgag accacaaaat cagcagacag ggtcacttat gcagaaaagt tgtcacctct   4920

tacaggtcaa gcttgcagat actgtgacct taaagaactc cacaattgca ctggaaattc   4980

atctcagcac tttttcagac agggttctct cgccagtagt aagccagctt ctaatccaaa   5040

atttagcagc cgctatcaga aatctaggat ttttcatctc agtgtccctc agattcatgt   5100

taatcttgat aagaaggcag tgcttgctga gaagatagtt gctgaagcca ttgaaaaagc   5160

tgagcgagag ctgagcagta ccagcctggc agccgacagt gggatcggac aggagggtgc   5220

cagctttgct gaaagccttg ccacagaaac catgacagca gctgtcacaa atgttgggca   5280

tgctgttagc agttcaaaag aaatagaaga ctttcagtca accgagtctg tcagtagcca   5340

gcagatgaac ctcagtattg gtgatgacag cactggtagc tggtccaatt taagttttga   5400

agatgaacac caagatgaaa gcagcagttt tcatcatcta agtgaaagta atggtaacag   5460

cagtagctgg agcagtcttg gtttagaagg agatttgtat gaggacaatt tatcctttcc   5520

aacatcagac agtgatggac cagatgataa agatgaagag catgaggacg aagtagaagg   5580

tttggggcaa gatggaaaga cactgctaat tacgaatatt gacatggagc catgcacggt   5640

agacccccag ctaaggatta ttcttcagtg gctcattgcc tctgaggctg aagttgcaga   5700

actttatttt catgactctg caaataagga gtttatgcta ctttcaaaac aattacaaga   5760

gaaaggatgg aaagtgggag acctcctgca ggctgtgctt caatactatg aagtgatgga   5820

aaaagcttcc agtgaggaga gatgcaagtc gctgtttgat tggctcttgg aaaatgcata   5880

gagcaaaccc caaaccagta tattttagta tttgtttggg gaggggaaca agccaataaa   5940

gatgtttagg ataaaatttg aatagtgaat attaacatcg taagtcagtt gggaggcaag   6000

taaatatagc tttctgagcg ctttgtgtta tcactcggtg tatatagttc atacttttgt   6060

aatctgtcaa aatactacct tcatttattc ttctatacac atgtgtagtg tgtcaagacc   6120

ctaagaacat gtatttgaag gaaggtctaa ccagggggtt ttcaggggca ttgtctgacc   6180

acattctttt tgtatccaaa tagtgctgct agaaactgca ctgaagtggc tgaggatagg   6240

ttccagtgat agagttataa ttttgctcct ttgcaaacaa atggtatcta attaataact   6300

agtctgacat cagaaaataa aattgaggct gatttttaaa aatttctagt agatttttgg   6360

cctttcctgt ttttaaaaat cagtttcatt ttcatatttc atagatcagc tattggtagc   6420

tttttgattt ccccaaacta tttaatttct tagcagaaac attagtattt taggtttcta   6480

taaacactat aagtgatagt ttcccccatc ctttcattga cattatttgc caatgctgcc   6540

agtcattctg gcatgaaagg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg   6600

tgtaagggag tactttaacc ttgccagttt gttccctctt ttattttact gttttctttt   6660

tagaaaccca ctgttaaaat ttaaaaaggt gctttaaaat aaaacgccta taaagattgt   6720

gcagtaagaa tttttattga caataattaa aatttttttt gacaattttg ggttcccaac   6780

ttatcttaca agtgaaaact taaattgtaa aacatgttga aattttaaaa attaatgtta   6840

atatggaaat gcatttagag aagcccagta gtttttattg ttggattttt gaaaaaacct   6900

ctaccaagaa tgtggtgttt tttttgtttg tttgtttgtt tgttttagaa aaattgggat   6960

ttccccccac cccgccccac ccagataaac tatatctaca ctgtctcgtc aagttctctg   7020

acacgatctt tctgggctct acatttccta ctagtttgtg tccagaaact gcaagttgac   7080

atgaatagag gacaaaggtt gtgtcttgct tttgtctctc tcttccctcc ctgcaactct   7140

ctctcccctc ctcccactct cttccccctc ccccctcctc ccactgtctc tcacctcccc   7200

caccccccac tctctctcat ctctcgctgt gtcctgtgta tgtgtgggtg tgtgtgtatt   7260

tgggtgtgta aatgttggtt cttccactac tggattttgt aatctaggat aaatcacttt   7320

ttttggggac tttgattttg ctccattacg ttttcatttt ttctgagcac tgactgttct   7380

gaaagctgca caaaacgtag aaagaagaca tagcgcctgc cagggaatag gaaatgaggg   7440

cacttacaca ttaatgtgaa ttagtaattg tggtatagaa atgttttata gtgaaagatt   7500

caaatttgct tttcaagaaa aatgccaaaa gctatttaaa taattcgagg ttacatcgta   7560

ggttttgatt tttctcaatt taagatacag aaatacagca agccttaata taaagtttcc   7620

taaagtttct tcaagtattt tttaaggtgg agaaatgcag gaattgtata accagaattg   7680

ttcctgcctt tagcttttca gaacttgaga tgtggcagca ctggactggg tttttttaaa   7740

tgttaggact aggaatgttt gctcttgtta attatgaatt aattgattat taagtttaga   7800

atgcattttt acaagtatct aactatcaaa ttgtgtttag taacttgagt gtatgcacaa   7860

gtttgatcaa cagcaaaata gagttctgaa tttcttttaa agtgatgata tattattttg   7920

tgaaactttg tgtttgaaaa tgtttatttc tgtttatggt gtaatcattc tgaggtgagg   7980

cttttcttat ttcctttgca ttttgctaga gctgtgctga gttcagcatt tgcttattta   8040

accactacat aatgacagac cagttattag gtattagcat gtgtggtaat aataatagtg   8100

gaacttcaca cttacatcaa ttcagtgcag gggcatagaa taaaatatta aatattggca   8160

gatgtatgaa aagaagtgtg agttaaaaat attgaatatt ggcaggtgtg aaaacaagtg   8220

tcaaaattcc tcatatagag aaaataattt tgagtttaga gtattatctt ttaattaagt   8280

gtagtctaaa cttaactttc tgtaaaggca ctttgtggtt tttccaaaga tgttctagat   8340

ctatttggtt gctctatagt caaacagctc ttttgaagac aactgtctta ttttattaca   8400

aattggcttg acatatttat actgtaacat tgtaatattg ctgtgctgta cattttggcc   8460

cttacgaaat acgtcttttt cagaactgtt aaagttttga tgtacatcga gctgaattct   8520

gtttttacca gtttcaaaac cttcaagtga tatgtggaaa aaagtgaatg agacctctga   8580

tagggggttt tcagaacctt gttcacacca aaatgtgaca gttctttcat gttttcctaa   8640

accaagttaa aattacatgt atattttggt gttaaggttg atttttaaga tacttctgat   8700

ttgtacaaaa ggaatgtttc ctttataaat cacagaagaa aatgacaata tctgttggat   8760

atttgatata atttaatggt gttataaaac ctttaagagg attcatggtg aatatatgtg   8820

ataacatctt tatactttga aaaatgttcc acttaccctt cagatatttg ttgtaagtta   8880

attcaattct taatacttta attttgctcc aacaagggct ttatgttgct ggtaagagaa   8940

tttatttact aaatgcacta tgtataaagt gaaagatagt ttacttatct gactttgata   9000

ttagatggct gacattagtg cacataatgc agagtttaac cttgattctt caacagagtc   9060

cagatttaaa tgtctactta gttaattagt tagctgatat tcttccacaa ttaatatatt   9120

caatttccca tcagtatatc actttaaatt ttatgttttt ctaaggaaac tttccacaga   9180

attttaaaca actgatgcat ccatactcag ggtgtaggga gaatactttg catttaaaaa   9240

ccctgtccac ctgtcaccag cacaagagaa ttagagcttc agtgagaatt tagaaaaatt   9300

atactaaagt gagatgcatt ttttctcatt ttcagcaaga ctcctctaag catttactca   9360

tttactgtat tcctgctctg aagatgtgga tacagaatta gtcactcttg tcactttatt   9420

tatttattgg ttttttttta accatctgtg tacattcctt tcatagggta gagttctagt   9480

tctagaagtt cttattttgt ttttgttgta atgtttgaat actatttaat atccggtttt   9540

aatattgctg gatttgctac ctttggttac ttgtgcagtg ttaaaagtaa tccactttct   9600

tgtttaatat accagataca tagcaaaagc agcttggaat aattatagct gtttatttgg   9660

ctgtgctcag ttactatatt aagatcttgt actgtgtaac agtaactctt ttttgctttt   9720

cagtaattta atatgttcac ttaacaaaat acgaactttg agatgcacta aagttttgtt   9780

tcagcagtgg ctcaaaaaat ttcagaaatt acttttgtaa ttatttgcaa ttaattgttc   9840

ttttatctta caattgttta agcctgtgat ctttcttctc ccagctaaga gttcttcaat   9900

aaatttaaga aatacctgg                                                9919


<210>  442
<211>  1901
<212>  PRT
<213>  Homo sapiens

<400>  442


Met Ala Thr Phe Arg Asn Asn His Met Lys Thr Lys Ala Ser Val Arg 
1               5                   10                  15      


Lys Ser Phe Ser Glu Asp Val Phe Gln Ser Val Lys Ser Leu Leu Gln 
            20                  25                  30          


Ser Gln Lys Glu Leu Cys Ser Val Thr Ala Glu Asp Cys Leu Gln Gln 
        35                  40                  45              


Asp Glu His Ala Asn Leu Thr Glu Val Thr Phe Leu Gly Phe Asn Glu 
    50                  55                  60                  


Glu Thr Asp Ala Ala His Ile Gln Asp Leu Ala Ala Val Ser Leu Glu 
65                  70                  75                  80  


Leu Pro Asp Ile Leu Asn Ser Leu His Phe Cys Ser Leu Asn Glu Asn 
                85                  90                  95      


Glu Ile Ile Cys Met Lys Asn Ile Asn Lys Pro Leu Asp Ile Ser Ser 
            100                 105                 110         


Asp Pro Leu Asn Gln Ser His Pro Ser Gly Met Leu Cys Val Met Arg 
        115                 120                 125             


Val Ser Pro Thr Ser Pro Arg Leu Arg Ile Asp Phe Ile Phe Ser Leu 
    130                 135                 140                 


Leu Ser Lys Tyr Ala Thr Gly Ile Arg Tyr Thr Leu Asp Thr Phe Leu 
145                 150                 155                 160 


His Gln Lys His Gln Leu Glu Thr Thr Asp Glu Asp Asp Asp Asp Thr 
                165                 170                 175     


Asn Gln Ser Val Ser Ser Ile Glu Asp Asp Phe Val Thr Ala Phe Glu 
            180                 185                 190         


His Leu Glu Glu Glu Glu Thr Ser Lys Pro Tyr Asn Asp Gly Met Asn 
        195                 200                 205             


Ile Thr Val Leu Arg Ser Gln Cys Asp Ala Ala Ser Gln Thr Val Thr 
    210                 215                 220                 


Gly His His Leu Glu Thr His Asp Leu Lys Ile Leu Ile Ser Ser Gly 
225                 230                 235                 240 


Gln Gln Lys Ser Leu Ala Lys Pro Ser Thr Ser Ser Val Asn Val Leu 
                245                 250                 255     


Gly His Lys Glu Leu Pro Ser Val Lys Thr Ser Val Thr Thr Ser Ile 
            260                 265                 270         


Ser Glu Pro Trp Thr Gln Arg Ser Phe Tyr Arg Ser Ser Asn Ala Ser 
        275                 280                 285             


Asp Lys Asp Ser Asp Leu Gln Lys Thr Phe Phe Ser Ser Ser Pro Ala 
    290                 295                 300                 


Tyr Ser Ser Glu Ser Glu Cys Ser Ser Pro Ser Pro Val Ile Phe Leu 
305                 310                 315                 320 


Asp Glu Glu Gly Tyr Gln Lys Ser Leu Lys Ala Lys Leu Glu Leu Pro 
                325                 330                 335     


Lys Ile Pro Val Met Lys Asp Asp Ile Glu Asp Ser Asp Ser Glu Val 
            340                 345                 350         


Ser Glu Phe Phe Asp Ser Phe Asp Gln Phe Asp Glu Leu Glu Gln Thr 
        355                 360                 365             


Leu Glu Thr Cys Leu Phe Asn Lys Asp Pro Val Ile Gly Lys Ser Ser 
    370                 375                 380                 


Gln Arg Lys Gly His Lys His Gly Lys Ser Cys Met Asn Pro Gln Lys 
385                 390                 395                 400 


Phe Lys Phe Asp Arg Pro Ala Leu Pro Ala Asn Val Arg Lys Pro Thr 
                405                 410                 415     


Pro Arg Lys Pro Glu Ser Pro Tyr Gly Asn Leu Cys Asp Ala Pro Asp 
            420                 425                 430         


Ser Pro Arg Pro Val Lys Ala Ser Arg Glu Asp Ser Gly Leu Phe Ser 
        435                 440                 445             


Pro Ile Arg Ser Ser Ala Phe Ser Pro Leu Gly Gly Cys Thr Pro Ala 
    450                 455                 460                 


Glu Cys Phe Cys Gln Thr Asp Ile Gly Gly Asp Arg Ile His Glu Asn 
465                 470                 475                 480 


His Asp Ser Val Tyr Tyr Thr Tyr Glu Asp Tyr Ala Lys Ser Ile Ser 
                485                 490                 495     


Cys Glu Val Leu Gly Ser Val Leu Arg Thr His His Thr Asn Thr Leu 
            500                 505                 510         


Ser Asn Ile Asn Ser Ile Lys His Gly Glu Asn Lys Thr Val Thr Phe 
        515                 520                 525             


Lys His Gly Asn Leu Asp Gln Lys Asn Lys Ser Lys Asn Lys Ser Leu 
    530                 535                 540                 


Met Ile Lys Asp Ser Ile Gln Lys Phe Ala Ala Asp Leu Val Glu Lys 
545                 550                 555                 560 


Ser Phe Gly Ser Ala Phe Lys Asp Leu Gln Lys Gly Val Ser Ser Cys 
                565                 570                 575     


Thr Asn Ala Leu Tyr His Leu Ala Ile Lys Leu Thr Ser Ser Val Leu 
            580                 585                 590         


Gln Met Ala Phe Asp Glu Leu Arg Arg Gln Arg Ala Phe Ser Leu Lys 
        595                 600                 605             


Glu Arg Ala Ile Ser Gly Leu Ala Asn Phe Leu Val Ser Glu Ala Leu 
    610                 615                 620                 


Ser Asn Ala Leu Lys Asp Leu Gln Tyr Val Lys Lys Gln Ile Phe Thr 
625                 630                 635                 640 


Asn Thr Val Ala Arg Phe Ala Ala Asp Leu Ala Glu Glu Leu Val Phe 
                645                 650                 655     


Glu Gly Ile Met Glu Val Cys Gln Phe Ser Tyr Pro Gln Thr Pro Ala 
            660                 665                 670         


Ser Pro Gln Cys Gly Ser Phe Asp Phe Glu Asp Lys Val Val Lys Leu 
        675                 680                 685             


Tyr Ala Lys Asp Leu Ser Glu Ser Val Ile Gln Glu Ala Phe Ile Glu 
    690                 695                 700                 


Leu Ser Gln Val Asp Val Thr Phe Thr Thr Lys Ala Ala Val Ser Val 
705                 710                 715                 720 


Ser Thr Asp Asn Ile Lys Tyr Val Ser Ala Glu Ser Val Val Pro Ser 
                725                 730                 735     


Thr Gln Ala Val Thr Phe Ser Pro Ser Phe His Asn Gln Ala Ile Met 
            740                 745                 750         


Val Thr Lys Pro Val Gln Glu Tyr Lys Lys Glu Tyr Thr Val Gln Gln 
        755                 760                 765             


Ala Leu Phe Cys Thr Ser Gly Ile Val Thr Ser Ile Pro Val Pro Leu 
    770                 775                 780                 


Ala Gly Ser Ala Leu Leu Pro Tyr His Ile Ser Ser Thr Ala Cys Gln 
785                 790                 795                 800 


Ala Lys Ala His Leu Ser Ser Asp Asp Ser Asn Ser Asn Gly Asp Ser 
                805                 810                 815     


Ala Gln Val His Ile Ala Thr Lys Asn Arg Glu Glu Lys Ala Ala Cys 
            820                 825                 830         


Leu Arg Asn Ile Cys Leu Pro Ser Glu His Asn Pro Gly Asn Gln Asn 
        835                 840                 845             


Asp Phe Lys Pro Thr Asn Asp Asp Ile Glu Met Gln Ser Ser Ser Lys 
    850                 855                 860                 


Leu Pro Asn Asp Pro Ala Ile Ile Ser Asn Phe Ser Ala Ala Val Val 
865                 870                 875                 880 


His Thr Ile Val Asn Glu Thr Leu Glu Ser Met Thr Ser Leu Glu Val 
                885                 890                 895     


Thr Lys Met Val Asp Glu Arg Thr Asp Tyr Leu Thr Lys Ser Leu Lys 
            900                 905                 910         


Glu Lys Thr Pro Pro Phe Ser His Cys Asp Gln Ala Val Leu Gln Cys 
        915                 920                 925             


Ser Glu Ala Ser Ser Asn Lys Asp Met Phe Ala Asp Arg Leu Ser Lys 
    930                 935                 940                 


Ser Ile Ile Lys His Ser Ile Asp Lys Ser Lys Ser Val Ile Pro Asn 
945                 950                 955                 960 


Ile Asp Lys Asn Ala Val Tyr Lys Glu Ser Leu Pro Val Ser Gly Glu 
                965                 970                 975     


Glu Ser Gln Leu Thr Pro Glu Lys Ser Pro Lys Phe Pro Asp Ser Gln 
            980                 985                 990         


Asn Gln Leu Thr His Cys Ser Leu  Ser Ala Ala Lys Asp  Cys Val Pro 
        995                 1000                 1005             


Glu Cys  Lys Val Ser Met Val  His Gly Ser Ser Leu  Glu Thr Leu 
    1010                 1015                 1020             


Pro Ser  Cys Pro Ala Val Thr  Gly Gln Lys Ser Asp  Leu Lys Glu 
    1025                 1030                 1035             


Ser Ala  Lys Asp Gln Pro Leu  Lys Lys His Asn Leu  Asn Ser Thr 
    1040                 1045                 1050             


Ser Leu  Glu Ala Leu Ser Phe  Gly Gln Glu Asn Pro  Phe Pro His 
    1055                 1060                 1065             


Ser His  Thr Phe Ser Ser Thr  Ala Leu Thr Cys Val  Asp Gly Leu 
    1070                 1075                 1080             


His Val  Glu Asp Lys Gln Lys  Val Arg Asp Arg Asn  Val Ile Pro 
    1085                 1090                 1095             


Asp Thr  Pro Pro Ser Thr Pro  Leu Val Pro Ser Arg  Ala Ser Ser 
    1100                 1105                 1110             


Glu Trp  Asp Ile Lys Lys Leu  Thr Lys Lys Leu Lys  Gly Glu Leu 
    1115                 1120                 1125             


Ala Lys  Glu Phe Ala Pro Ala  Thr Pro Pro Ser Thr  Pro His Asn 
    1130                 1135                 1140             


Ser Ser  Val Gly Ser Leu Ser  Glu Asn Glu Gln Asn  Thr Ile Glu 
    1145                 1150                 1155             


Lys Glu  Glu Phe Met Leu Lys  Leu Met Arg Ser Leu  Ser Glu Glu 
    1160                 1165                 1170             


Val Glu  Ser Ser Glu Ser Gly  Glu Leu Pro Glu Val  Asp Val Lys 
    1175                 1180                 1185             


Ser Glu  His Ser Gly Lys Lys  Val Gln Phe Ala Glu  Ala Leu Ala 
    1190                 1195                 1200             


Thr His  Ile Leu Ser Leu Ala  Thr Glu Met Ala Ala  Ser His Leu 
    1205                 1210                 1215             


Asp Asn  Lys Ile Ile Gln Glu  Pro Lys Val Lys Asn  Pro Cys Leu 
    1220                 1225                 1230             


Asn Val  Gln Ser Gln Arg Ser  Val Ser Pro Thr Phe  Leu Asn Pro 
    1235                 1240                 1245             


Ser Asp  Glu Asn Leu Lys Thr  Leu Cys Asn Phe Ala  Gly Asp Leu 
    1250                 1255                 1260             


Ala Ala  Glu Val Ile Thr Glu  Ala Glu Lys Ile Ala  Lys Val Arg 
    1265                 1270                 1275             


Asn Cys  Met Leu Phe Lys Gln  Lys Lys Asn Ser Cys  Tyr Ala Asp 
    1280                 1285                 1290             


Gly Asp  Glu Asp Tyr Lys Val  Glu Glu Lys Leu Asp  Ile Glu Ala 
    1295                 1300                 1305             


Val Val  His Pro Arg Glu Val  Asp Pro Phe Ile Leu  Ser Leu Pro 
    1310                 1315                 1320             


Pro Ser  Ser Cys Met Ser Gly  Leu Met Tyr Lys Tyr  Pro Ser Cys 
    1325                 1330                 1335             


Glu Ser  Val Thr Asp Glu Tyr  Ala Gly His Leu Ile  Gln Ile Leu 
    1340                 1345                 1350             


Lys Gln  Glu Gly Gly Asn Ser  Glu Leu Ile Met Asp  Gln Tyr Ala 
    1355                 1360                 1365             


Asn Arg  Leu Ala Tyr Arg Ser  Val Lys Ser Gly Leu  Gln Glu Ala 
    1370                 1375                 1380             


Ala Lys  Thr Thr Lys Val Gln  Cys Asn Ser Arg Met  Phe Pro Val 
    1385                 1390                 1395             


Pro Ser  Ser Gln Val Lys Thr  Asn Lys Glu Leu Leu  Met Phe Ser 
    1400                 1405                 1410             


Asn Lys  Glu His His Gln Glu  Ala Asp Lys Lys Arg  Gln Ser Lys 
    1415                 1420                 1425             


Arg Asn  Glu Gly Tyr Phe Cys  Lys Asn Gln Thr Cys  Glu Arg Thr 
    1430                 1435                 1440             


Leu Asp  Pro Tyr Arg Asn Glu  Val Ser Gln Leu Tyr  Ser Phe Ser 
    1445                 1450                 1455             


Thr Ser  Leu Val His Ser Ile  Thr Lys Asp Ala Lys  Glu Glu Leu 
    1460                 1465                 1470             


Thr Ala  Ser Leu Val Gly Leu  Pro Lys Ser Leu Thr  Asp Ser Cys 
    1475                 1480                 1485             


Leu Phe  Glu Lys Ser Gly Tyr  Glu Glu Asp Asn Glu  Cys His Val 
    1490                 1495                 1500             


Thr Pro  Glu Leu Pro Lys Ser  Leu Gln Pro Ser Ser  Gln Asn His 
    1505                 1510                 1515             


Arg Phe  Tyr His Ser Thr Gly  Ser Leu Asn Gly Tyr  Gly Cys Gly 
    1520                 1525                 1530             


Asp Asn  Val Val Gln Ala Val  Glu Gln Tyr Ala Lys  Lys Val Val 
    1535                 1540                 1545             


Asp Asp  Thr Leu Glu Leu Thr  Leu Gly Ser Thr Val  Phe Arg Val 
    1550                 1555                 1560             


Ser Glu  Thr Thr Lys Ser Ala  Asp Arg Val Thr Tyr  Ala Glu Lys 
    1565                 1570                 1575             


Leu Ser  Pro Leu Thr Gly Gln  Ala Cys Arg Tyr Cys  Asp Leu Lys 
    1580                 1585                 1590             


Glu Leu  His Asn Cys Thr Gly  Asn Ser Ser Gln His  Phe Phe Arg 
    1595                 1600                 1605             


Gln Gly  Ser Leu Ala Ser Ser  Lys Pro Ala Ser Asn  Pro Lys Phe 
    1610                 1615                 1620             


Ser Ser  Arg Tyr Gln Lys Ser  Arg Ile Phe His Leu  Ser Val Pro 
    1625                 1630                 1635             


Gln Ile  His Val Asn Leu Asp  Lys Lys Ala Val Leu  Ala Glu Lys 
    1640                 1645                 1650             


Ile Val  Ala Glu Ala Ile Glu  Lys Ala Glu Arg Glu  Leu Ser Ser 
    1655                 1660                 1665             


Thr Ser  Leu Ala Ala Asp Ser  Gly Ile Gly Gln Glu  Gly Ala Ser 
    1670                 1675                 1680             


Phe Ala  Glu Ser Leu Ala Thr  Glu Thr Met Thr Ala  Ala Val Thr 
    1685                 1690                 1695             


Asn Val  Gly His Ala Val Ser  Ser Ser Lys Glu Ile  Glu Asp Phe 
    1700                 1705                 1710             


Gln Ser  Thr Glu Ser Val Ser  Ser Gln Gln Met Asn  Leu Ser Ile 
    1715                 1720                 1725             


Gly Asp  Asp Ser Thr Gly Ser  Trp Ser Asn Leu Ser  Phe Glu Asp 
    1730                 1735                 1740             


Glu His  Gln Asp Glu Ser Ser  Ser Phe His His Leu  Ser Glu Ser 
    1745                 1750                 1755             


Asn Gly  Asn Ser Ser Ser Trp  Ser Ser Leu Gly Leu  Glu Gly Asp 
    1760                 1765                 1770             


Leu Tyr  Glu Asp Asn Leu Ser  Phe Pro Thr Ser Asp  Ser Asp Gly 
    1775                 1780                 1785             


Pro Asp  Asp Lys Asp Glu Glu  His Glu Asp Glu Val  Glu Gly Leu 
    1790                 1795                 1800             


Gly Gln  Asp Gly Lys Thr Leu  Leu Ile Thr Asn Ile  Asp Met Glu 
    1805                 1810                 1815             


Pro Cys  Thr Val Asp Pro Gln  Leu Arg Ile Ile Leu  Gln Trp Leu 
    1820                 1825                 1830             


Ile Ala  Ser Glu Ala Glu Val  Ala Glu Leu Tyr Phe  His Asp Ser 
    1835                 1840                 1845             


Ala Asn  Lys Glu Phe Met Leu  Leu Ser Lys Gln Leu  Gln Glu Lys 
    1850                 1855                 1860             


Gly Trp  Lys Val Gly Asp Leu  Leu Gln Ala Val Leu  Gln Tyr Tyr 
    1865                 1870                 1875             


Glu Val  Met Glu Lys Ala Ser  Ser Glu Glu Arg Cys  Lys Ser Leu 
    1880                 1885                 1890             


Phe Asp  Trp Leu Leu Glu Asn  Ala 
    1895                 1900     

<210>  443
<211>  3808
<212>  DNA
<213>  Homo sapiens

<400>  443
caggtgattt ttggtggggc ggggacatga aaaaaaagtt aaaatgtcct tataaagaca     60

aaatcttttt ctttcctggc tgatgatttg tcattctagt cacttcctgc cttgtgacca    120

cacacccagg cttgacaaag ctgttctgca gatcagaaag aaggggttcc tggtcataca    180

ccagtactac caaggacagc ttttttcctg caagatctgt tacctaaagc aataaaaaat    240

ggccagagga tcagtgtccg atgaggaaat gatggagctc agagaagctt ttgccaaagt    300

tgatactgat ggcaatggat acatcagctt caatgagttg aatgacttgt tcaaggctgc    360

ttgcttgcct ttgcctgggt atagagtacg agaaattaca gaaaacctga tggctacagg    420

tgatctggac caagatggaa ggatcagctt tgatgagttt atcaagattt tccatggcct    480

aaaaagcaca gatgttgcca agacctttag aaaagcaatc aataagaagg aagggatttg    540

tgcaatcggt ggtacttcag agcagtctag cgttggcacc caacactcct attcagagga    600

agaaaagtat gcctttgtca actggataaa caaagccctg gaaaatgatc ctgattgtcg    660

gcatgtcatc ccaatgaacc caaacacgaa tgatctcttt aatgctgttg gagatggcat    720

tgtcctttgt aaaatgatca acctgtcagt gccagacaca attgatgaaa gaacaatcaa    780

caaaaagaag ctaacccctt tcaccattca ggaaaatctg aacttggctc tgaactctgc    840

ctcagccatc gggtgccatg tggtcaacat aggggctgag gacctgaagg aggggaagcc    900

ttatctggtc ctgggacttc tgtggcaagt catcaagatt gggttgtttg ctgacattga    960

actcagcaga aatgaagctc tgattgctct tttgagagaa ggtgagagcc tggaggattt   1020

gatgaaactc tcccctgaag agctcttgct gaggtgggct aattaccacc tggaaaatgc   1080

aggctgcaac aaaattggca acttcagtac tgacatcaag gactcaaaag cttattacca   1140

cctgcttgag caggtggctc caaaaggaga tgaagaaggt gttcctgctg ttgttattga   1200

catgtcagga ctgcgggaga aggatgacat ccagagggca gaatgcatgc tgcagcaggc   1260

ggagaggctg ggctgccggc agtttgtcac agccacagat gttgtccgag ggaaccccaa   1320

gttgaacttg gcttttattg ccaacctctt taacagatac cctgccctgc acaaaccaga   1380

gaaccaggac attgactggg gggctcttga aggtgagacg agagaagagc ggacatttag   1440

gaactggatg aactccctgg gtgttaaccc tcgagtcaat catttgtaca gtgacttatc   1500

agatgccctg gtcatcttcc agctctatga aaagatcaaa gttcctgttg actggaacag   1560

agtaaacaaa ccgccatacc ccaaactggg aggcaatatg aagaagcttg agaattgtaa   1620

ctacgcggta gaattgggga agaatcaagc gaagttctcc ctggttggca tcggtggaca   1680

agatctcaat gaaggaaacc gcactctcac actggccttg atttggcagc taatgagaag   1740

gtatacactg aatatcctcg aagaaattgg tggtggccag aaggtcaatg atgacattat   1800

tgtcaactgg gtgaatgaaa cattgaggga agcaaagaaa agttcatcca tctctagttt   1860

caaggacccg aagattagta caagtctgcc tgttctggac ctcatcgatg ccatccaacc   1920

aggttccatt aactatgacc ttctgaagac agaaaatctg aatgatgatg agaaactcaa   1980

caatgcaaaa tatgccatct ctatggcccg aaaaattgga gcaagagtgt atgccctgcc   2040

agaagacctg gttgaagtga accccaaaat ggtcatgacc gtgtttgcct gcctcatggg   2100

gaaaggaatg aagagggtgt gaggcccaat ggggctgggt gggaggcggt gcactcactc   2160

ctgactgccc ggcacagatg ctccagggat gattcaagcc attccaaagt tcaacttggt   2220

gacactctat aagattccaa aaagcacata ttagtgcagc caagtagcct ctcctgtatt   2280

taacaaaaag tgcttcattc tttgcaggag gcccaacctc ctatatatag gtttctattc   2340

ttgatttatt tgcttcttcg aaaatctaga ggaaaagaaa gaagttattt tccaggtacc   2400

cttctcgctt ttgccattag ccaaggatag aagctgcagt ggtattaatt ttgatataat   2460

ctttcaaacc agcttcatgt ggcttccctt ttctttgttc aagatgaggg ccaggagggg   2520

aaacatcaca cctgccctaa accctgttcc tggaggtcag catttgatct gttgcaagcc   2580

cctctttctg tcccctcttc ctaccctgcc tcccttgact ttgctcctca cacttttgga   2640

accatgcctt ccgggggggc ccatctcttc tggccgtcct tgtctctggg ccacttggag   2700

tgtgtgataa atcagtcaag ctgttgaagt ctcaggagtc tctggtagcc tgcagaagta   2760

agcctcatca tcagagcctt tcctcaaaac tggagtccca aatgtcatca ggttttgttt   2820

tttttcagcc actaagaacc cctctgcttt taactctaga atttgggctt ggaccagatc   2880

taacatcttg aatactctgc cctctagagc cttcagcctt aatggaaggt tggatccaag   2940

gagggtgtaa tggagcatca agccactcgg cggcagcatg gagctataac taagcatcct   3000

ttagggttct gcctctccag gcatttagcc ctcacattag atctagttac tgtggtatgg   3060

ctaatacctg tcaacatttg gaggcaatcc taccttgctt ttgcttctag agcttagcat   3120

atctgattgt tgtcaggcca tattatcaat gtttactttt ttggtactat aaaagctttc   3180

tgccacccct aaactccagg ggggacaata tgtgccaatc aatagcaccc ctactcacat   3240

acacacacac ctagccagct gtcaagggca gaatgaatct atgctggata agaaatggtg   3300

gaactgcgtt atgaagagct aatttactgg acaaagaatt ccaaagcaaa accagaacag   3360

tatgaatttg agcaggtctc ataggttgag caatttcccc ctaaaccaac tgaaggctaa   3420

aaagcaacag gccattgtga accaatgcaa gacgccctct atcatggtga aaagctccat   3480

caatgaggta tcttctttag tggtggtatg taatggaact tagccatttt tcaaagcaat   3540

tgaaatgcat tgctctggat ctgttccttg gcagtggact cagaaagcca acatgtggct   3600

cctcccagcc cataaccagt atttttgctg cttctgaata caaattggtt ggttttgact   3660

tcagattgaa cttactgtag cctcagatga tttcccccct ccgcctccag gaagaaagaa   3720

tgttactgcc ttaataaaaa atgaaaagag aatgatgctc aaaatctttc caaataaaat   3780

gttccctata aaaaaaaaaa aaaaaaaa                                      3808


<210>  444
<211>  627
<212>  PRT
<213>  Homo sapiens

<400>  444


Met Ala Arg Gly Ser Val Ser Asp Glu Glu Met Met Glu Leu Arg Glu 
1               5                   10                  15      


Ala Phe Ala Lys Val Asp Thr Asp Gly Asn Gly Tyr Ile Ser Phe Asn 
            20                  25                  30          


Glu Leu Asn Asp Leu Phe Lys Ala Ala Cys Leu Pro Leu Pro Gly Tyr 
        35                  40                  45              


Arg Val Arg Glu Ile Thr Glu Asn Leu Met Ala Thr Gly Asp Leu Asp 
    50                  55                  60                  


Gln Asp Gly Arg Ile Ser Phe Asp Glu Phe Ile Lys Ile Phe His Gly 
65                  70                  75                  80  


Leu Lys Ser Thr Asp Val Ala Lys Thr Phe Arg Lys Ala Ile Asn Lys 
                85                  90                  95      


Lys Glu Gly Ile Cys Ala Ile Gly Gly Thr Ser Glu Gln Ser Ser Val 
            100                 105                 110         


Gly Thr Gln His Ser Tyr Ser Glu Glu Glu Lys Tyr Ala Phe Val Asn 
        115                 120                 125             


Trp Ile Asn Lys Ala Leu Glu Asn Asp Pro Asp Cys Arg His Val Ile 
    130                 135                 140                 


Pro Met Asn Pro Asn Thr Asn Asp Leu Phe Asn Ala Val Gly Asp Gly 
145                 150                 155                 160 


Ile Val Leu Cys Lys Met Ile Asn Leu Ser Val Pro Asp Thr Ile Asp 
                165                 170                 175     


Glu Arg Thr Ile Asn Lys Lys Lys Leu Thr Pro Phe Thr Ile Gln Glu 
            180                 185                 190         


Asn Leu Asn Leu Ala Leu Asn Ser Ala Ser Ala Ile Gly Cys His Val 
        195                 200                 205             


Val Asn Ile Gly Ala Glu Asp Leu Lys Glu Gly Lys Pro Tyr Leu Val 
    210                 215                 220                 


Leu Gly Leu Leu Trp Gln Val Ile Lys Ile Gly Leu Phe Ala Asp Ile 
225                 230                 235                 240 


Glu Leu Ser Arg Asn Glu Ala Leu Ile Ala Leu Leu Arg Glu Gly Glu 
                245                 250                 255     


Ser Leu Glu Asp Leu Met Lys Leu Ser Pro Glu Glu Leu Leu Leu Arg 
            260                 265                 270         


Trp Ala Asn Tyr His Leu Glu Asn Ala Gly Cys Asn Lys Ile Gly Asn 
        275                 280                 285             


Phe Ser Thr Asp Ile Lys Asp Ser Lys Ala Tyr Tyr His Leu Leu Glu 
    290                 295                 300                 


Gln Val Ala Pro Lys Gly Asp Glu Glu Gly Val Pro Ala Val Val Ile 
305                 310                 315                 320 


Asp Met Ser Gly Leu Arg Glu Lys Asp Asp Ile Gln Arg Ala Glu Cys 
                325                 330                 335     


Met Leu Gln Gln Ala Glu Arg Leu Gly Cys Arg Gln Phe Val Thr Ala 
            340                 345                 350         


Thr Asp Val Val Arg Gly Asn Pro Lys Leu Asn Leu Ala Phe Ile Ala 
        355                 360                 365             


Asn Leu Phe Asn Arg Tyr Pro Ala Leu His Lys Pro Glu Asn Gln Asp 
    370                 375                 380                 


Ile Asp Trp Gly Ala Leu Glu Gly Glu Thr Arg Glu Glu Arg Thr Phe 
385                 390                 395                 400 


Arg Asn Trp Met Asn Ser Leu Gly Val Asn Pro Arg Val Asn His Leu 
                405                 410                 415     


Tyr Ser Asp Leu Ser Asp Ala Leu Val Ile Phe Gln Leu Tyr Glu Lys 
            420                 425                 430         


Ile Lys Val Pro Val Asp Trp Asn Arg Val Asn Lys Pro Pro Tyr Pro 
        435                 440                 445             


Lys Leu Gly Gly Asn Met Lys Lys Leu Glu Asn Cys Asn Tyr Ala Val 
    450                 455                 460                 


Glu Leu Gly Lys Asn Gln Ala Lys Phe Ser Leu Val Gly Ile Gly Gly 
465                 470                 475                 480 


Gln Asp Leu Asn Glu Gly Asn Arg Thr Leu Thr Leu Ala Leu Ile Trp 
                485                 490                 495     


Gln Leu Met Arg Arg Tyr Thr Leu Asn Ile Leu Glu Glu Ile Gly Gly 
            500                 505                 510         


Gly Gln Lys Val Asn Asp Asp Ile Ile Val Asn Trp Val Asn Glu Thr 
        515                 520                 525             


Leu Arg Glu Ala Lys Lys Ser Ser Ser Ile Ser Ser Phe Lys Asp Pro 
    530                 535                 540                 


Lys Ile Ser Thr Ser Leu Pro Val Leu Asp Leu Ile Asp Ala Ile Gln 
545                 550                 555                 560 


Pro Gly Ser Ile Asn Tyr Asp Leu Leu Lys Thr Glu Asn Leu Asn Asp 
                565                 570                 575     


Asp Glu Lys Leu Asn Asn Ala Lys Tyr Ala Ile Ser Met Ala Arg Lys 
            580                 585                 590         


Ile Gly Ala Arg Val Tyr Ala Leu Pro Glu Asp Leu Val Glu Val Asn 
        595                 600                 605             


Pro Lys Met Val Met Thr Val Phe Ala Cys Leu Met Gly Lys Gly Met 
    610                 615                 620                 


Lys Arg Val 
625         

<210>  445
<211>  1899
<212>  DNA
<213>  Homo sapiens

<400>  445
ggaccccggt tgctagggtg tgtctccttg gcctcctaga gggtggggat ccgtggtgct     60

tcttcgggaa cagcctcctg caggaagacc ctcgctggac ctttacctcg ctgcctagat    120

tccgaggaaa aggagatagg agacgaaaag ccagttggtt tggaaagcgg ccgattatcc    180

taaagggtag tgtgggagtc cagcacttcc atgcccctct ttgggtacta cggaagggag    240

atttccagca tcgtgtggaa catatgacca gggagtacac cttgagcgct tgtgtgcagt    300

tatcttttgg cggattatga aaaacagcac ttattattca ttaaaatgca aaagccccca    360

ctgcttcttc gaagaccctt acctccaaaa ttcactaagc tgtctttaca tgagaaaaaa    420

acccatacag ctaaaactgg taaaattgag tcactacatg tagcattcac tgaagatgaa    480

accacttcca ttaaaatgga tagaactcgt tttcctgatg ttttaagaaa tcaatcacta    540

acacctatca atatccaaaa tatctttctt gatcactgtg tacaagaaag agtgactgca    600

atttcatcac cccagaaatc tactaagcat gtccgtgagc agattccaga tactgctact    660

ggttccatat tttttccaca ttgtaattca gcttctactc gaatttttgg gaaacaaaca    720

aacaaaatgg aaagttcaag aaagtttaaa actatgaaag atgtttatac tgaaaaaagg    780

ctagaaaaca ttttaattct ttcttccaag ttttccaaac ctaaaagtac tcctggctca    840

gttatcgctc aaaaacttga gaaaatgcac cctaagcatc aacctttacc agagagtcca    900

ggctatactt atcagcacat ctcgagagac ttaagtgcaa cagtgccaag ccctccacct    960

atgactgtat ctatgaaacc agaaggacag tggcctgaac attttaaatc aactgctaca   1020

ttgacactaa gagttactga atttccaggt tttgtttcct tgccaacacc agttttacca   1080

agaaaacctc acaggcagtc tgtgatagaa actcttgtaa cagaaaatgg aaatatagaa   1140

agtgtcccaa agcaaatccc accaagacca cctgaaggtc tcaccaaaac tgaaaaaata   1200

gaatcagaga tacacgttgt acgtggtgaa ggttttaaga ctgttgcagc aacacgatat   1260

gaaacaataa cagccatgac caacctggcc atagtaaact gtcaagtata tgggagaaat   1320

gcacttaatc tgaagggctt ttttatccta aattgtccag acttaacacc tttggctttc   1380

cagttgatat atcttaattt atcatttaat gatcttcatt actttcccac agaaatatta   1440

tgtcttaaaa atttacaaat actgaaattg agaaataatc ctatcaaaga aattccttct   1500

gaaattcaac aacttgagtt ccttagaatt ttcaccattg cttttaattt aattactgtt   1560

cttccaattg ggttattttc cttgtcttat cttgaagaac ttgatgtttc ctataatgaa   1620

cttactttta ttccaaatga aattcagaaa ctcagatcac ttgaaaaact gactgttgat   1680

gggaatgaac tgagtttttt cccccatgga attttgaagc ttaacctgac aaaaattcag   1740

tttgagaata atttcactca tccttgtttt tggagagata attatttgaa taatccacaa   1800

caacttactc aaattatttc tttgttcatt gtccaaaata aactacataa attttatgat   1860

aagatcccag tagaagttca gaagttacta aaatggtga                          1899


<210>  446
<211>  517
<212>  PRT
<213>  Homo sapiens

<400>  446


Met Gln Lys Pro Pro Leu Leu Leu Arg Arg Pro Leu Pro Pro Lys Phe 
1               5                   10                  15      


Thr Lys Leu Ser Leu His Glu Lys Lys Thr His Thr Ala Lys Thr Gly 
            20                  25                  30          


Lys Ile Glu Ser Leu His Val Ala Phe Thr Glu Asp Glu Thr Thr Ser 
        35                  40                  45              


Ile Lys Met Asp Arg Thr Arg Phe Pro Asp Val Leu Arg Asn Gln Ser 
    50                  55                  60                  


Leu Thr Pro Ile Asn Ile Gln Asn Ile Phe Leu Asp His Cys Val Gln 
65                  70                  75                  80  


Glu Arg Val Thr Ala Ile Ser Ser Pro Gln Lys Ser Thr Lys His Val 
                85                  90                  95      


Arg Glu Gln Ile Pro Asp Thr Ala Thr Gly Ser Ile Phe Phe Pro His 
            100                 105                 110         


Cys Asn Ser Ala Ser Thr Arg Ile Phe Gly Lys Gln Thr Asn Lys Met 
        115                 120                 125             


Glu Ser Ser Arg Lys Phe Lys Thr Met Lys Asp Val Tyr Thr Glu Lys 
    130                 135                 140                 


Arg Leu Glu Asn Ile Leu Ile Leu Ser Ser Lys Phe Ser Lys Pro Lys 
145                 150                 155                 160 


Ser Thr Pro Gly Ser Val Ile Ala Gln Lys Leu Glu Lys Met His Pro 
                165                 170                 175     


Lys His Gln Pro Leu Pro Glu Ser Pro Gly Tyr Thr Tyr Gln His Ile 
            180                 185                 190         


Ser Arg Asp Leu Ser Ala Thr Val Pro Ser Pro Pro Pro Met Thr Val 
        195                 200                 205             


Ser Met Lys Pro Glu Gly Gln Trp Pro Glu His Phe Lys Ser Thr Ala 
    210                 215                 220                 


Thr Leu Thr Leu Arg Val Thr Glu Phe Pro Gly Phe Val Ser Leu Pro 
225                 230                 235                 240 


Thr Pro Val Leu Pro Arg Lys Pro His Arg Gln Ser Val Ile Glu Thr 
                245                 250                 255     


Leu Val Thr Glu Asn Gly Asn Ile Glu Ser Val Pro Lys Gln Ile Pro 
            260                 265                 270         


Pro Arg Pro Pro Glu Gly Leu Thr Lys Thr Glu Lys Ile Glu Ser Glu 
        275                 280                 285             


Ile His Val Val Arg Gly Glu Gly Phe Lys Thr Val Ala Ala Thr Arg 
    290                 295                 300                 


Tyr Glu Thr Ile Thr Ala Met Thr Asn Leu Ala Ile Val Asn Cys Gln 
305                 310                 315                 320 


Val Tyr Gly Arg Asn Ala Leu Asn Leu Lys Gly Phe Phe Ile Leu Asn 
                325                 330                 335     


Cys Pro Asp Leu Thr Pro Leu Ala Phe Gln Leu Ile Tyr Leu Asn Leu 
            340                 345                 350         


Ser Phe Asn Asp Leu His Tyr Phe Pro Thr Glu Ile Leu Cys Leu Lys 
        355                 360                 365             


Asn Leu Gln Ile Leu Lys Leu Arg Asn Asn Pro Ile Lys Glu Ile Pro 
    370                 375                 380                 


Ser Glu Ile Gln Gln Leu Glu Phe Leu Arg Ile Phe Thr Ile Ala Phe 
385                 390                 395                 400 


Asn Leu Ile Thr Val Leu Pro Ile Gly Leu Phe Ser Leu Ser Tyr Leu 
                405                 410                 415     


Glu Glu Leu Asp Val Ser Tyr Asn Glu Leu Thr Phe Ile Pro Asn Glu 
            420                 425                 430         


Ile Gln Lys Leu Arg Ser Leu Glu Lys Leu Thr Val Asp Gly Asn Glu 
        435                 440                 445             


Leu Ser Phe Phe Pro His Gly Ile Leu Lys Leu Asn Leu Thr Lys Ile 
    450                 455                 460                 


Gln Phe Glu Asn Asn Phe Thr His Pro Cys Phe Trp Arg Asp Asn Tyr 
465                 470                 475                 480 


Leu Asn Asn Pro Gln Gln Leu Thr Gln Ile Ile Ser Leu Phe Ile Val 
                485                 490                 495     


Gln Asn Lys Leu His Lys Phe Tyr Asp Lys Ile Pro Val Glu Val Gln 
            500                 505                 510         


Lys Leu Leu Lys Trp 
        515         

<210>  447
<211>  563
<212>  DNA
<213>  Homo sapiens

<400>  447
gcatgcagct caacatcctc tgagactctg tcctcatttt gcgaaattag ggacaaccag     60

acctatcttc ctgtcctatc ataagaatta aagaagacat gggagtattc cgtatacaga    120

ggaaagcaga gggagtcttg aaacagcaga agaggagaca gcaatgcaat cacagaagca    180

gagattggag caatgtggcc acgccacaag gaatgcccac agcaccagaa gctgaaagag    240

gcaagaaatg gattctccct aagagcctct ggaaggaaca cagccttctt ggtttgggcc    300

cagtgaaact cactatagaa cctctggcct ccagaactgt gagagcatac atttctgttg    360

gtttaaatca gcaagtttgt ggtaatttgt tacaccctag gtttacggtc taatacacca    420

cctcagatga ggagaatgag aactccatta tgggaaaggt aaaatgaaaa tttagaagtg    480

gctaagttgc cagataactc tgaaaccata acagctctga gcttccttca tcagactttt    540

ttaaatgaga aagggataaa ctt                                            563


<210>  448
<211>  104
<212>  PRT
<213>  Homo sapiens

<400>  448


Met Gly Val Phe Arg Ile Gln Arg Lys Ala Glu Gly Val Leu Lys Gln 
1               5                   10                  15      


Gln Lys Arg Arg Gln Gln Cys Asn His Arg Ser Arg Asp Trp Ser Asn 
            20                  25                  30          


Val Ala Thr Pro Gln Gly Met Pro Thr Ala Pro Glu Ala Glu Arg Gly 
        35                  40                  45              


Lys Lys Trp Ile Leu Pro Lys Ser Leu Trp Lys Glu His Ser Leu Leu 
    50                  55                  60                  


Gly Leu Gly Pro Val Lys Leu Thr Ile Glu Pro Leu Ala Ser Arg Thr 
65                  70                  75                  80  


Val Arg Ala Tyr Ile Ser Val Gly Leu Asn Gln Gln Val Cys Gly Asn 
                85                  90                  95      


Leu Leu His Pro Arg Phe Thr Val 
            100                 

<210>  449
<211>  563
<212>  DNA
<213>  Homo sapiens

<400>  449
gtgctcctct ggaagccctc tgactaccag ccgcttgtct cttcttccgc agttgagaaa     60

tagacggtcc acagcggaca acttagaatg gaataaggga gatgtgtttg aggcactacc    120

attggaagat gtgctgggga gaagcccagc ccagcaacat gcggcaggac cacatctcgg    180

cagagctgaa gacagagaca ttgcagcgac aaggacaact ggcatgcctc acattcctca    240

gtgttgaaaa caataaaagg agggggaatg agagaaaaat caaatttcta cgaagagatg    300

tcagcagtaa atttaatgca gctgccacaa acagagtgaa tgcagagcca tcaagagcca    360

agttctacaa gagataaatc agctgagact accactagac atctgcaagc agaagattag    420

gagagtaaat ttgcgagaca catatgcata tgacccagaa accaagttgc gtgaaactac    480

catggtttgt gcctcgatag gttgaacaag gacatggtga gaagacagcc atctgcaagc    540

cagaaagagc gctaaccaga acg                                            563


<210>  450
<211>  72
<212>  PRT
<213>  Homo sapiens

<400>  450


Met Arg Gln Asp His Ile Ser Ala Glu Leu Lys Thr Glu Thr Leu Gln 
1               5                   10                  15      


Arg Gln Gly Gln Leu Ala Cys Leu Thr Phe Leu Ser Val Glu Asn Asn 
            20                  25                  30          


Lys Arg Arg Gly Asn Glu Arg Lys Ile Lys Phe Leu Arg Arg Asp Val 
        35                  40                  45              


Ser Ser Lys Phe Asn Ala Ala Ala Thr Asn Arg Val Asn Ala Glu Pro 
    50                  55                  60                  


Ser Arg Ala Lys Phe Tyr Lys Arg 
65                  70          

<210>  451
<211>  2498
<212>  DNA
<213>  Homo sapiens

<400>  451
accagcaccc cgcccagagc agtgccgctg cccaaatcct cgcaggcagc tcatcaacgc     60

aattgcaact ccggctggag ccccggacct gcaagcctgg gtgtccgtgg gtccgtctgc    120

ccagccatct gctggtggca cctctccctc ctgccgcctc cctcggtgaa ccccaccttg    180

cagaagtgca gctcgcccgg agcagcccag gagctcagca tgcgtccccc aggcttcagg    240

aacttcttgc tgctggcgtc ctcccttctc tttgctgggt tgtcagctgt tcctcaaagc    300

ttctcgccat ctctgaggag ctggccgggc gccgcctgca ggctgtcccg ggccgagtcg    360

gagcgacgct gccgcgcacc tgggcagccc ccgggggccg cgctgtgcca cggccggggc    420

cgctgcgact gcggcgtctg catctgccac gtgactgagc cgggcatgtt cttcgggccc    480

ctgtgtgagt gccatgagtg ggtgtgcgag acctacgacg ggagcacctg tgcaggccat    540

ggtaagtgtg actgtggcaa gtgcaagtgt gaccagggat ggtatgggga tgcttgccag    600

tacccaacta actgtgactt gacaaagaag aaaagtaacc aaatgtgcaa gaattcacaa    660

gacatcatct gctctaatgc aggtacatgt cactgtggca ggtgtaagtg tgataattca    720

gatggaagtg gacttgtgta tggtaaattt tgtgagtgtg acgatagaga atgcatagac    780

gatgaaacag aagaaatatg tggaggccat gggaagtgtt actgtggaaa ctgctactgc    840

aaggctggtt ggcatggaga taaatgtgaa ttccagtgcg atatcacccc ctgggaaagc    900

aagcgaagat gcacgtctcc agatggcaaa atctgcagta acagagggac ttgtgtatgt    960

ggtgaatgta cctgtcacga tgttgatccg actggggact ggggagatat tcatggggac   1020

acctgtgaat gtgatgagag ggactgtaga gctgtctatg accgatattc tgatgacttc   1080

tgttcaggtc atggacagtg taattgcgga agatgtgact gcaaagcagg ctggtatggg   1140

aagaagtgtg agcacccaca gtcctgcacg ctgtcagctg aggagagcat caggaagtgc   1200

cagggaagct cggatctgcc ttgctctggg aggggtaaat gtgaatgtgg caaatgcacc   1260

tgctatcctc caggagatcg ccgggtgtat ggcaagactt gtgagtgtga tgatcgccgc   1320

tgtgaagacc tcgatggtgt ggtctgtgga ggccacggca catgttcctg tggtcgctgt   1380

gtttgtgaga gaggatggtt tggaaagctc tgccaacatc cgcggaagtg taacatgacg   1440

gaagaacaaa gcaagaatct gtgtgaatca gcagatggca tattgtgctc ggggaagggt   1500

tcttgtcatt gtgggaagtg catttgttct gctgaagagt ggtatatttc tggggagttc   1560

tgtgactgtg atgacagaga ctgcgacaaa catgatggtc tcatttgtac agggaatgga   1620

atatgtagct gtggaaactg tgaatgctgg gatggatgga atggaaatgc atgtgaaatc   1680

tggcttggct cagaatatcc ttaacaatta catgagagag gtctggattc ttattttttc   1740

tgggccatta gaacatataa atgcgaagga aaccatgtat attcaccact aggacaggtt   1800

aaaaagacca ttgtatgttt ttctatttct gaattacgaa tgaaatccga gtacctatta   1860

gaaatgagtt atgcaaattt agatgcaaat aacattagaa aaaaaagatt cttccataat   1920

taacataagt ggttcctaac gagagcaatt tttccaccca aaagtcattt ggcaacatct   1980

acagacaatt ttgattgtca cactgggtcg ggtaggaagg tatgctgcag acatttggtg   2040

ggtagaggcc agggatgctg ctgagcatcc cgcagtgtac aggacagccc ccaaacaagg   2100

aattatccag ccccaaatgc caatagggct cagactgaga aacattgagt tatatggcta   2160

ttagaaatcc acattcttac acaagaaaga ccatattaga atctaaggaa aacatgcata   2220

ttcacattaa ttaatcgatc agatttttcc agaattccgt atcagtcacc attttaatat   2280

ggggacaatg aagacaagca cacaggaggt agaatatcag agtggggctg gatcaagggc   2340

aaaaactggt cattaagtca tctgacatta aatcatttag ccactaagtt atttgtgtac   2400

tctcacttta aactcaccaa agaagattct cttaaagaaa ttatgaaaaa tgtacaattt   2460

aacattttaa ataaatagtg acagaagttg tttaaaaa                           2498


<210>  452
<211>  494
<212>  PRT
<213>  Homo sapiens

<400>  452


Met Arg Pro Pro Gly Phe Arg Asn Phe Leu Leu Leu Ala Ser Ser Leu 
1               5                   10                  15      


Leu Phe Ala Gly Leu Ser Ala Val Pro Gln Ser Phe Ser Pro Ser Leu 
            20                  25                  30          


Arg Ser Trp Pro Gly Ala Ala Cys Arg Leu Ser Arg Ala Glu Ser Glu 
        35                  40                  45              


Arg Arg Cys Arg Ala Pro Gly Gln Pro Pro Gly Ala Ala Leu Cys His 
    50                  55                  60                  


Gly Arg Gly Arg Cys Asp Cys Gly Val Cys Ile Cys His Val Thr Glu 
65                  70                  75                  80  


Pro Gly Met Phe Phe Gly Pro Leu Cys Glu Cys His Glu Trp Val Cys 
                85                  90                  95      


Glu Thr Tyr Asp Gly Ser Thr Cys Ala Gly His Gly Lys Cys Asp Cys 
            100                 105                 110         


Gly Lys Cys Lys Cys Asp Gln Gly Trp Tyr Gly Asp Ala Cys Gln Tyr 
        115                 120                 125             


Pro Thr Asn Cys Asp Leu Thr Lys Lys Lys Ser Asn Gln Met Cys Lys 
    130                 135                 140                 


Asn Ser Gln Asp Ile Ile Cys Ser Asn Ala Gly Thr Cys His Cys Gly 
145                 150                 155                 160 


Arg Cys Lys Cys Asp Asn Ser Asp Gly Ser Gly Leu Val Tyr Gly Lys 
                165                 170                 175     


Phe Cys Glu Cys Asp Asp Arg Glu Cys Ile Asp Asp Glu Thr Glu Glu 
            180                 185                 190         


Ile Cys Gly Gly His Gly Lys Cys Tyr Cys Gly Asn Cys Tyr Cys Lys 
        195                 200                 205             


Ala Gly Trp His Gly Asp Lys Cys Glu Phe Gln Cys Asp Ile Thr Pro 
    210                 215                 220                 


Trp Glu Ser Lys Arg Arg Cys Thr Ser Pro Asp Gly Lys Ile Cys Ser 
225                 230                 235                 240 


Asn Arg Gly Thr Cys Val Cys Gly Glu Cys Thr Cys His Asp Val Asp 
                245                 250                 255     


Pro Thr Gly Asp Trp Gly Asp Ile His Gly Asp Thr Cys Glu Cys Asp 
            260                 265                 270         


Glu Arg Asp Cys Arg Ala Val Tyr Asp Arg Tyr Ser Asp Asp Phe Cys 
        275                 280                 285             


Ser Gly His Gly Gln Cys Asn Cys Gly Arg Cys Asp Cys Lys Ala Gly 
    290                 295                 300                 


Trp Tyr Gly Lys Lys Cys Glu His Pro Gln Ser Cys Thr Leu Ser Ala 
305                 310                 315                 320 


Glu Glu Ser Ile Arg Lys Cys Gln Gly Ser Ser Asp Leu Pro Cys Ser 
                325                 330                 335     


Gly Arg Gly Lys Cys Glu Cys Gly Lys Cys Thr Cys Tyr Pro Pro Gly 
            340                 345                 350         


Asp Arg Arg Val Tyr Gly Lys Thr Cys Glu Cys Asp Asp Arg Arg Cys 
        355                 360                 365             


Glu Asp Leu Asp Gly Val Val Cys Gly Gly His Gly Thr Cys Ser Cys 
    370                 375                 380                 


Gly Arg Cys Val Cys Glu Arg Gly Trp Phe Gly Lys Leu Cys Gln His 
385                 390                 395                 400 


Pro Arg Lys Cys Asn Met Thr Glu Glu Gln Ser Lys Asn Leu Cys Glu 
                405                 410                 415     


Ser Ala Asp Gly Ile Leu Cys Ser Gly Lys Gly Ser Cys His Cys Gly 
            420                 425                 430         


Lys Cys Ile Cys Ser Ala Glu Glu Trp Tyr Ile Ser Gly Glu Phe Cys 
        435                 440                 445             


Asp Cys Asp Asp Arg Asp Cys Asp Lys His Asp Gly Leu Ile Cys Thr 
    450                 455                 460                 


Gly Asn Gly Ile Cys Ser Cys Gly Asn Cys Glu Cys Trp Asp Gly Trp 
465                 470                 475                 480 


Asn Gly Asn Ala Cys Glu Ile Trp Leu Gly Ser Glu Tyr Pro 
                485                 490                 

<210>  453
<211>  2317
<212>  DNA
<213>  Homo sapiens

<400>  453
gagcctgggc agtgcacggg gcctgggtgg ggggtgcggg tgtgggtggg gacctgcggc     60

cttcgagtcc gcggccttcg agtcctgggg cggcggcggc ggctgcaggc acgggcacgg    120

gcacggggcg gggtgcttag ggtgcaggag gcgcgcgcct agcggcggag tgtggcgtga    180

ggccgggccc gcgccgccat gaacctagag cggctgcgga agcgcgtccg gcagtacctc    240

gaccagcaac agtatcaaag tgctctattt tgggcagata aagtagcttc actctctcgt    300

gaagaacccc aggacatcta ttggttggct cagtgtcttt acctgacagc acaatatcac    360

agagccgccc atgcacttcg gtcacgaaaa ctggacaaat tgtatgaagc atgtcgttac    420

cttgcagcta ggtgccatta tgctgcaaaa gagcaccagc aggcccttga tgttcttgac    480

atggaagagc ccatcaataa aagattattt gaaaaatact tgaaggacga aagtggcttc    540

aaagatcctt ccagcgactg ggaaatgtca cagtcttcaa taaagagttc tatctgtctt    600

ctacgcggga aaatctatga tgctctagat aaccgaaccc tggctaccta cagctacaaa    660

gaagctttga agcttgatgt ctactgtttt gaagcgttcg atcttttaac atcacatcac    720

atgctgacag cacaagaaga aaaagaactt cttgaatcac taccccttag caagctgtgt    780

aatgaagaac aggaattgct gcgttttcta tttgagaaca aattgaaaaa atataataag    840

cctagtgaaa cggtcatccc tgaatctgta gatggcttgc aagagaatct ggatgtggta    900

gtgtctttag ctgagagaca ttattataac tgtgatttta aaatgtgcta caagcttact    960

tctgtagtaa tggagaaaga tcctttccat gcaagttgtt tacctgtaca tatagggacg   1020

cttgtagagc tgaataaagc caatgaactt ttctatcttt ctcataaact ggtggattta   1080

tatcctagta atcctgtgtc ttggtttgca gtgggatgtt actatctcat ggtcggtcat   1140

aaaaatgaac atgccagaag atatctcagc aaagccacaa cacttgagaa aacctatgga   1200

cctgcatgga tagcctatgg acattcattt gcggtggaga gtgagcacga ccaagcgatg   1260

gctgcttact tcacagcagc acagctgatg aaagggtgtc atttgcctat gctgtatatt   1320

ggattagaat atggtttgac caataactca aaactagctg aaaggttctt cagccaagct   1380

ctgagcattg caccggaaga cccttttgtt atgcatgagg tcggcgtggt tgcatttcag   1440

aatggagaat ggaaaacagc cgaaaaatgg tttcttgatg ctttggaaaa aattaaagca   1500

attgggaacg aggtaacagt tgacaaatgg gaacctttgt tgaacaactt ggggcatgtc   1560

tgcagaaaac ttaaaaagta tgctgaggcc ttggattacc accgtcaggc actggtgttg   1620

attcctcaga acgcatccac ctactctgct attggatata tccacagtct gatgggcaac   1680

tttgaaaatg ctgtggacta cttccacaca gcccttggtc ttaggcgaga tgatacattt   1740

tctgttacaa tgcttggtca ttgcatcgaa atgtacattg gtgattctga agcttatatt   1800

ggagcagaca ttaaagacaa attaaaatgt tatgactttg atgtgcatac aatgaagaca   1860

ctaaaaaaca ttatttcacc tccgtgggat ttcagggaat ttgaagtaga aaaacagact   1920

gcagaagaaa cggggcttac gccattggaa acctcaagga aaactccaga ttccagacct   1980

tccttggaag aaacctttga aattgaaatg aatgaaagtg acatgatgtt agagacatct   2040

atgtcagacc acagcacgtg actccagtca gtggtcctgg tcccactgtc ccagtgtagg   2100

ttagtattcc ttcacatcct ctccatggct taagaatgtc ccacttccta acgtgactcc   2160

aaactgcatc tctacattta ggaacagaga cccgccttaa gagactggat cgcacacctt   2220

tgcaacagat gtgttctgat tctctgaacc tacaaaatag ttatacatag tggaataaag   2280

aaggtaaacc atcaaaaaaa aaaaaaaaaa aaaaaaa                            2317


<210>  454
<211>  620
<212>  PRT
<213>  Homo sapiens

<400>  454


Met Asn Leu Glu Arg Leu Arg Lys Arg Val Arg Gln Tyr Leu Asp Gln 
1               5                   10                  15      


Gln Gln Tyr Gln Ser Ala Leu Phe Trp Ala Asp Lys Val Ala Ser Leu 
            20                  25                  30          


Ser Arg Glu Glu Pro Gln Asp Ile Tyr Trp Leu Ala Gln Cys Leu Tyr 
        35                  40                  45              


Leu Thr Ala Gln Tyr His Arg Ala Ala His Ala Leu Arg Ser Arg Lys 
    50                  55                  60                  


Leu Asp Lys Leu Tyr Glu Ala Cys Arg Tyr Leu Ala Ala Arg Cys His 
65                  70                  75                  80  


Tyr Ala Ala Lys Glu His Gln Gln Ala Leu Asp Val Leu Asp Met Glu 
                85                  90                  95      


Glu Pro Ile Asn Lys Arg Leu Phe Glu Lys Tyr Leu Lys Asp Glu Ser 
            100                 105                 110         


Gly Phe Lys Asp Pro Ser Ser Asp Trp Glu Met Ser Gln Ser Ser Ile 
        115                 120                 125             


Lys Ser Ser Ile Cys Leu Leu Arg Gly Lys Ile Tyr Asp Ala Leu Asp 
    130                 135                 140                 


Asn Arg Thr Leu Ala Thr Tyr Ser Tyr Lys Glu Ala Leu Lys Leu Asp 
145                 150                 155                 160 


Val Tyr Cys Phe Glu Ala Phe Asp Leu Leu Thr Ser His His Met Leu 
                165                 170                 175     


Thr Ala Gln Glu Glu Lys Glu Leu Leu Glu Ser Leu Pro Leu Ser Lys 
            180                 185                 190         


Leu Cys Asn Glu Glu Gln Glu Leu Leu Arg Phe Leu Phe Glu Asn Lys 
        195                 200                 205             


Leu Lys Lys Tyr Asn Lys Pro Ser Glu Thr Val Ile Pro Glu Ser Val 
    210                 215                 220                 


Asp Gly Leu Gln Glu Asn Leu Asp Val Val Val Ser Leu Ala Glu Arg 
225                 230                 235                 240 


His Tyr Tyr Asn Cys Asp Phe Lys Met Cys Tyr Lys Leu Thr Ser Val 
                245                 250                 255     


Val Met Glu Lys Asp Pro Phe His Ala Ser Cys Leu Pro Val His Ile 
            260                 265                 270         


Gly Thr Leu Val Glu Leu Asn Lys Ala Asn Glu Leu Phe Tyr Leu Ser 
        275                 280                 285             


His Lys Leu Val Asp Leu Tyr Pro Ser Asn Pro Val Ser Trp Phe Ala 
    290                 295                 300                 


Val Gly Cys Tyr Tyr Leu Met Val Gly His Lys Asn Glu His Ala Arg 
305                 310                 315                 320 


Arg Tyr Leu Ser Lys Ala Thr Thr Leu Glu Lys Thr Tyr Gly Pro Ala 
                325                 330                 335     


Trp Ile Ala Tyr Gly His Ser Phe Ala Val Glu Ser Glu His Asp Gln 
            340                 345                 350         


Ala Met Ala Ala Tyr Phe Thr Ala Ala Gln Leu Met Lys Gly Cys His 
        355                 360                 365             


Leu Pro Met Leu Tyr Ile Gly Leu Glu Tyr Gly Leu Thr Asn Asn Ser 
    370                 375                 380                 


Lys Leu Ala Glu Arg Phe Phe Ser Gln Ala Leu Ser Ile Ala Pro Glu 
385                 390                 395                 400 


Asp Pro Phe Val Met His Glu Val Gly Val Val Ala Phe Gln Asn Gly 
                405                 410                 415     


Glu Trp Lys Thr Ala Glu Lys Trp Phe Leu Asp Ala Leu Glu Lys Ile 
            420                 425                 430         


Lys Ala Ile Gly Asn Glu Val Thr Val Asp Lys Trp Glu Pro Leu Leu 
        435                 440                 445             


Asn Asn Leu Gly His Val Cys Arg Lys Leu Lys Lys Tyr Ala Glu Ala 
    450                 455                 460                 


Leu Asp Tyr His Arg Gln Ala Leu Val Leu Ile Pro Gln Asn Ala Ser 
465                 470                 475                 480 


Thr Tyr Ser Ala Ile Gly Tyr Ile His Ser Leu Met Gly Asn Phe Glu 
                485                 490                 495     


Asn Ala Val Asp Tyr Phe His Thr Ala Leu Gly Leu Arg Arg Asp Asp 
            500                 505                 510         


Thr Phe Ser Val Thr Met Leu Gly His Cys Ile Glu Met Tyr Ile Gly 
        515                 520                 525             


Asp Ser Glu Ala Tyr Ile Gly Ala Asp Ile Lys Asp Lys Leu Lys Cys 
    530                 535                 540                 


Tyr Asp Phe Asp Val His Thr Met Lys Thr Leu Lys Asn Ile Ile Ser 
545                 550                 555                 560 


Pro Pro Trp Asp Phe Arg Glu Phe Glu Val Glu Lys Gln Thr Ala Glu 
                565                 570                 575     


Glu Thr Gly Leu Thr Pro Leu Glu Thr Ser Arg Lys Thr Pro Asp Ser 
            580                 585                 590         


Arg Pro Ser Leu Glu Glu Thr Phe Glu Ile Glu Met Asn Glu Ser Asp 
        595                 600                 605             


Met Met Leu Glu Thr Ser Met Ser Asp His Ser Thr 
    610                 615                 620 

<210>  455
<211>  2235
<212>  DNA
<213>  Homo sapiens

<400>  455
gagcctgggc agtgcacggg gcctgggtgg ggggtgcggg tgtgggtggg gacctgcggc     60

cttcgagtcc gcggccttcg agtcctgggg cggcggcggc ggctgcaggc acgggcacgg    120

gcacggggcg gggtgcttag ggtgcaggag gcgcgcgcct agcggcggag tgtggcgtga    180

ggccgggccc gcgccgccat gaacctagag cggctgcgga agcgcgtccg gcagtacctc    240

gaccagcaac agtatcaaag tgctctattt tgggcagata aagtagcttc actctctcgt    300

gaagaacccc aggacatcta ttggttggct cagtgtcttt acctgacagc acaatatcac    360

agagccgccc atgcacttcg gtcacgaaaa ctggacaaat tgtatgaagc atgtcgttac    420

cttgcagcta ggtgccatta tgctgcaaaa gagcaccagc aggcccttga tgttcttgac    480

atggaagagc ccatcaataa aagattattt gaaaaatact tgaaggacga aagtggcttc    540

aaagatcctt ccagcgactg ggaaatgtca cagtcttcaa taaagagttc tatctgtctt    600

ctacgcggga aaatctatga tgctctagat aaccgaaccc tggctaccta cagctacaaa    660

gaagctttga agcttgatgt ctactgtttt gaagcgttcg atcttttaac atcacatcac    720

atgctgacag cacaagaaga aaaagaactt cttgaatcac taccccttag caagctgtgt    780

aatgaagaac aggaattgct gcgttttcta tttgagaaca aattgaaaaa atataataag    840

cctagtgaaa cggtcatccc tgaatctgta gatggcttgc aagagaatct ggatgtggta    900

gtgtctttag ctgagagaca ttattataac tgtgatttta aaatgtgcta caagcttact    960

tctgtagtaa tggagaaaga tcctttccat gcaagttgtt tacctgtaca tatagggacg   1020

cttgtagagc tgaataaagc caatgaactt ttctatcttt ctcataaact ggtggattta   1080

tatcctagta atcctgtgtc ttggtttgca gtgggatgtt actatctcat ggtcggtcat   1140

aaaaatgaac atgccagaag atatctcagc aaagccacaa cacttgagaa aacctatgga   1200

cctgcatgga tagcctatgg acattcattt gcggtggaga gtgagcacga ccaagcgatg   1260

gctgcttact tcacagcagc acagctgatg aaagggtgtc atttgcctat gctgtatatt   1320

ggattagaat atggtttgac caataactca aaactagctg aaaggttctt cagccaagct   1380

ctgagcattg caccggaaga cccttttgtt atgcatgagg tcggcgtggt tgcatttcag   1440

aatggagaat ggaaaacagc cgaaaaatgg tttcttgatg ctttggaaaa aattaaagca   1500

attgggaacg aggtaacagt tgacaaatgg gaacctttgt tgaacaactt ggggcatgtc   1560

tgcagaaaac ttaaaaagta tgctgaggcc ttggattacc accgtcaggc actggtgttg   1620

attcctcaga acgcatccac ctactctgct attggatata tccacagtct gatgggcaac   1680

tttgaaaatg ctgtggacta cttccacaca gcccttggtc ttaggcgaga tgatacattt   1740

tctgttacaa tgcttggtca ttgcatcgaa atgtacattg gtgattctga agcttatatt   1800

ggagcagaca ttaaagacaa attaaaatgt tatgactttg atgtgcatac aatgaagaca   1860

ctaaaaaaca ttatttcacc tccgtgggat ttcagggaat ttgaagtaga aaaacagact   1920

gcagaagaaa cggggcttac gccattggaa acctcaagga aaactccaga ttccagacct   1980

tccttggaag aaacctttga aattgaaatg aatgaaagtg acatgatgtt agagacatct   2040

atgtcagacc acagcacgtg actccagtca gtggtcctgg tcccactgtc ccagtgtagg   2100

aacagagacc cgccttaaga gactggatcg cacacctttg caacagatgt gttctgattc   2160

tctgaaccta caaaatagtt atacatagtg gaataaagaa ggtaaaccat caaaaaaaaa   2220

aaaaaaaaaa aaaaa                                                    2235


<210>  456
<211>  620
<212>  PRT
<213>  Homo sapiens

<400>  456


Met Asn Leu Glu Arg Leu Arg Lys Arg Val Arg Gln Tyr Leu Asp Gln 
1               5                   10                  15      


Gln Gln Tyr Gln Ser Ala Leu Phe Trp Ala Asp Lys Val Ala Ser Leu 
            20                  25                  30          


Ser Arg Glu Glu Pro Gln Asp Ile Tyr Trp Leu Ala Gln Cys Leu Tyr 
        35                  40                  45              


Leu Thr Ala Gln Tyr His Arg Ala Ala His Ala Leu Arg Ser Arg Lys 
    50                  55                  60                  


Leu Asp Lys Leu Tyr Glu Ala Cys Arg Tyr Leu Ala Ala Arg Cys His 
65                  70                  75                  80  


Tyr Ala Ala Lys Glu His Gln Gln Ala Leu Asp Val Leu Asp Met Glu 
                85                  90                  95      


Glu Pro Ile Asn Lys Arg Leu Phe Glu Lys Tyr Leu Lys Asp Glu Ser 
            100                 105                 110         


Gly Phe Lys Asp Pro Ser Ser Asp Trp Glu Met Ser Gln Ser Ser Ile 
        115                 120                 125             


Lys Ser Ser Ile Cys Leu Leu Arg Gly Lys Ile Tyr Asp Ala Leu Asp 
    130                 135                 140                 


Asn Arg Thr Leu Ala Thr Tyr Ser Tyr Lys Glu Ala Leu Lys Leu Asp 
145                 150                 155                 160 


Val Tyr Cys Phe Glu Ala Phe Asp Leu Leu Thr Ser His His Met Leu 
                165                 170                 175     


Thr Ala Gln Glu Glu Lys Glu Leu Leu Glu Ser Leu Pro Leu Ser Lys 
            180                 185                 190         


Leu Cys Asn Glu Glu Gln Glu Leu Leu Arg Phe Leu Phe Glu Asn Lys 
        195                 200                 205             


Leu Lys Lys Tyr Asn Lys Pro Ser Glu Thr Val Ile Pro Glu Ser Val 
    210                 215                 220                 


Asp Gly Leu Gln Glu Asn Leu Asp Val Val Val Ser Leu Ala Glu Arg 
225                 230                 235                 240 


His Tyr Tyr Asn Cys Asp Phe Lys Met Cys Tyr Lys Leu Thr Ser Val 
                245                 250                 255     


Val Met Glu Lys Asp Pro Phe His Ala Ser Cys Leu Pro Val His Ile 
            260                 265                 270         


Gly Thr Leu Val Glu Leu Asn Lys Ala Asn Glu Leu Phe Tyr Leu Ser 
        275                 280                 285             


His Lys Leu Val Asp Leu Tyr Pro Ser Asn Pro Val Ser Trp Phe Ala 
    290                 295                 300                 


Val Gly Cys Tyr Tyr Leu Met Val Gly His Lys Asn Glu His Ala Arg 
305                 310                 315                 320 


Arg Tyr Leu Ser Lys Ala Thr Thr Leu Glu Lys Thr Tyr Gly Pro Ala 
                325                 330                 335     


Trp Ile Ala Tyr Gly His Ser Phe Ala Val Glu Ser Glu His Asp Gln 
            340                 345                 350         


Ala Met Ala Ala Tyr Phe Thr Ala Ala Gln Leu Met Lys Gly Cys His 
        355                 360                 365             


Leu Pro Met Leu Tyr Ile Gly Leu Glu Tyr Gly Leu Thr Asn Asn Ser 
    370                 375                 380                 


Lys Leu Ala Glu Arg Phe Phe Ser Gln Ala Leu Ser Ile Ala Pro Glu 
385                 390                 395                 400 


Asp Pro Phe Val Met His Glu Val Gly Val Val Ala Phe Gln Asn Gly 
                405                 410                 415     


Glu Trp Lys Thr Ala Glu Lys Trp Phe Leu Asp Ala Leu Glu Lys Ile 
            420                 425                 430         


Lys Ala Ile Gly Asn Glu Val Thr Val Asp Lys Trp Glu Pro Leu Leu 
        435                 440                 445             


Asn Asn Leu Gly His Val Cys Arg Lys Leu Lys Lys Tyr Ala Glu Ala 
    450                 455                 460                 


Leu Asp Tyr His Arg Gln Ala Leu Val Leu Ile Pro Gln Asn Ala Ser 
465                 470                 475                 480 


Thr Tyr Ser Ala Ile Gly Tyr Ile His Ser Leu Met Gly Asn Phe Glu 
                485                 490                 495     


Asn Ala Val Asp Tyr Phe His Thr Ala Leu Gly Leu Arg Arg Asp Asp 
            500                 505                 510         


Thr Phe Ser Val Thr Met Leu Gly His Cys Ile Glu Met Tyr Ile Gly 
        515                 520                 525             


Asp Ser Glu Ala Tyr Ile Gly Ala Asp Ile Lys Asp Lys Leu Lys Cys 
    530                 535                 540                 


Tyr Asp Phe Asp Val His Thr Met Lys Thr Leu Lys Asn Ile Ile Ser 
545                 550                 555                 560 


Pro Pro Trp Asp Phe Arg Glu Phe Glu Val Glu Lys Gln Thr Ala Glu 
                565                 570                 575     


Glu Thr Gly Leu Thr Pro Leu Glu Thr Ser Arg Lys Thr Pro Asp Ser 
            580                 585                 590         


Arg Pro Ser Leu Glu Glu Thr Phe Glu Ile Glu Met Asn Glu Ser Asp 
        595                 600                 605             


Met Met Leu Glu Thr Ser Met Ser Asp His Ser Thr 
    610                 615                 620 

<210>  457
<211>  3647
<212>  DNA
<213>  Homo sapiens

<400>  457
gttgtcatgg gggaggtggt ggcgcttggt ggccactggc ggccgaggta gaggcagtgg     60

cgcttgagtt ggtcgggggc agcggcagat ttgaggctta agcaacttct tccggggaag    120

agtgccagtg cagccactgt tacaattcaa gatcttgatc tatatccata gattggaata    180

ttggtgggcc agcaatcctc agacgcctca cttaggacaa atgaggaaac tgaggcttgg    240

tgaagttacg aaacttgtcc aaaatcacac aacttgtaaa gggcacagcc aagattcaga    300

gccaggctgt aaaaattaaa atgaacaaat tacggcaaag ttttaggaga aagaaggatg    360

tttatgttcc agaggccagt cgtccacatc agtggcagac agatgaagaa ggcgttcgca    420

ccggaaaatg tagcttcccg gttaagtacc ttggccatgt agaagttgat gaatcaagag    480

gaatgcacat ctgtgaagat gctgtaaaaa gattgaaagc tgaaaggaag ttcttcaaag    540

gcttctttgg aaaaactgga aagaaagcag ttaaagcagt tctgtgggtc tcagcagatg    600

gactcagagt tgtggatgaa aaaactaagg acctcatagt tgaccagacg atagagaaag    660

tttctttctg tgccccagac aggaactttg atagagcctt ttcttacata tgccgtgatg    720

gcaccactcg tcgctggatc tgtcactgct tcatggctgt caaggacaca ggtgaaaggt    780

tgagccatgc agtaggctgt gcttttgcag cctgtttaga gcgcaagcag aagcgggaga    840

aggaatgtgg agtgactgct acttttgatg ctagtcggac cacttttaca agagaaggat    900

cattccgtgt cacaacagcc actgaacaag cagaaagaga ggagatcatg aaacaaatgc    960

aagatgccaa gaaagctgaa acagataaga tagtcgttgg ttcatcagtt gcccctggca   1020

acactgcccc atccccatcc tctcccacct ctcctacttc tgatgccacg acctctctgg   1080

agatgaacaa tcctcatgcc atcccacgcc ggcatgctcc aattgaacag cttgctcgcc   1140

aaggctcttt ccgaggtttt cctgctctta gccagaagat gtcacccttt aaacgccaac   1200

tatccctacg catcaatgag ttgccttcca ctatgcagag gaagactgat ttccccatta   1260

aaaatgcagt gccagaagta gaaggggagg cagagagcat cagctccctg tgctcacaga   1320

tcaccaatgc cttcagcaca cctgaggacc ccttctcatc tgctccgatg accaaaccag   1380

tgacagtggt ggcaccacaa tctcctacct tccaagctaa tggcactgac tcagccttcc   1440

atgtgcttgc taagccagcc catactgctc tagcacccgt agcaatgcct gtgcgtgaaa   1500

ccaacccttg ggcccatgcc cctgatgctg ctaacaagga aattgcagcc acatgttcgg   1560

ggaccgagtg gggtcaatct tctggtgctg cctctccagg tctcttccag gccggtcata   1620

gacgtactcc ctctgaggcc gaccgatggt tagaagaggt gtctaagagc gtccgggctc   1680

agcagcccca ggcctcagct gctcctctgc agccagttct ccagcctcct ccacccactg   1740

ccatctccca gccagcatca cctttccaag ggaatgcatt cctcacctct cagcctgtgc   1800

cagtgggtgt ggtcccagcc ctgcaaccag cctttgtccc tgcccagtcc tatcctgtgg   1860

ccaatggaat gccctatcca gcccctaatg tgcctgtggt gggcatcact ccctcccaga   1920

tggtggccaa cgtatttggc actgcaggcc accctcaggc tgcccatccc catcagtcac   1980

ccagcctggt caggcagcag acattccctc actacgaggc aagcagtgct accaccagtc   2040

ccttctttaa gcctcctgct cagcacctca acggttctgc agctttcaat ggtgtagatg   2100

atggcaggtt ggcctcagca gacaggcata cagaggttcc tacaggcacc tgcccagtgg   2160

atccttttga agcccagtgg gctgcattag aaaataagtc caagcagcgt actaatccct   2220

cccctaccaa ccctttctcc agtgacttac agaagacgtt tgaaattgaa ctttaagcaa   2280

tcattatggc tatgtatctt gtccatacca gacagggagc agggggtagc ggtcaaagga   2340

gcaaaacaga ctttgtctcc tgattagtac tcttttcact aatcccaaag gtcccaagga   2400

acaagtccag gcccagagta ctgtgagggg tgattttgaa agacatggga aaaagcattc   2460

ctagagaaaa gctgccttgc aattaggcta aagaagtcaa ggaaatgttg ctttctgtac   2520

tccctcttcc cttaccccct tacaaatctc tggcaacaga gaggcaaagt atctgaacaa   2580

gaatctatat tccaagcaca tttactgaaa tgtaaaacac aacaggaagc aaagcaatct   2640

ccctttgttt ttcaggccat tcacctgcct cctgtcagta gtggcctgta ttagagatca   2700

agaagagtgg tttgtgctca ggctggggaa cagagaggca cgctatgctg ccagaattcc   2760

caggagggca tatcagcaac tgcccagcag agctatattt tgggggagaa gttgagcttc   2820

cattttgagt aacagaataa atattatata tatcaaaagc caaaatcttt atttttatgc   2880

atttagaata ttttaaatag ttctcagata ttaagaagtt gtatgagttg taagtaatct   2940

tgccaaaggt aaaggggcta gttgtaagaa attgtacata agattgattt atcattgatg   3000

cctactgaaa taaaaagagg aaaggctgga agctgcagac aggatcccta gcttgttttc   3060

tgtcagtcat tcattgtaag tagcacattg caacaacaat catgcttatg accaatacag   3120

tcactaggtt gtagtttttt ttaaataaag gaaaagcagt attgtcctgg ttttaaacct   3180

atgatggaat tctaatgtca ttattttaat ggaatcaatc gaaatatgct ctatagagaa   3240

tatatctttt atatattgct gcagtttcct tatgttaatc ctttaacact aaggtaacat   3300

gacataatca taccatagaa gggaacacag gttaccatat tggtttgtaa tatgggtctt   3360

ggtgggtttt gttttatcct ttaaattttg ttcccatgag ttttgtgggg atggggattc   3420

tggttttatt agctttgtgt gtgtcctctt cccccaaacc cccttttggt gagaacatcc   3480

ccttgacagt tgcagcctct tgacctcgga taacaataag agagctcatc tcatttttac   3540

ttttgaacgt tggccttaca atcaaatgta agttatatat atttgtactg atgaaaattt   3600

ataatctgct ttaacaaaaa taaatgttca tggtagaagc ttttaaa                 3647


<210>  458
<211>  651
<212>  PRT
<213>  Homo sapiens

<400>  458


Met Asn Lys Leu Arg Gln Ser Phe Arg Arg Lys Lys Asp Val Tyr Val 
1               5                   10                  15      


Pro Glu Ala Ser Arg Pro His Gln Trp Gln Thr Asp Glu Glu Gly Val 
            20                  25                  30          


Arg Thr Gly Lys Cys Ser Phe Pro Val Lys Tyr Leu Gly His Val Glu 
        35                  40                  45              


Val Asp Glu Ser Arg Gly Met His Ile Cys Glu Asp Ala Val Lys Arg 
    50                  55                  60                  


Leu Lys Ala Glu Arg Lys Phe Phe Lys Gly Phe Phe Gly Lys Thr Gly 
65                  70                  75                  80  


Lys Lys Ala Val Lys Ala Val Leu Trp Val Ser Ala Asp Gly Leu Arg 
                85                  90                  95      


Val Val Asp Glu Lys Thr Lys Asp Leu Ile Val Asp Gln Thr Ile Glu 
            100                 105                 110         


Lys Val Ser Phe Cys Ala Pro Asp Arg Asn Phe Asp Arg Ala Phe Ser 
        115                 120                 125             


Tyr Ile Cys Arg Asp Gly Thr Thr Arg Arg Trp Ile Cys His Cys Phe 
    130                 135                 140                 


Met Ala Val Lys Asp Thr Gly Glu Arg Leu Ser His Ala Val Gly Cys 
145                 150                 155                 160 


Ala Phe Ala Ala Cys Leu Glu Arg Lys Gln Lys Arg Glu Lys Glu Cys 
                165                 170                 175     


Gly Val Thr Ala Thr Phe Asp Ala Ser Arg Thr Thr Phe Thr Arg Glu 
            180                 185                 190         


Gly Ser Phe Arg Val Thr Thr Ala Thr Glu Gln Ala Glu Arg Glu Glu 
        195                 200                 205             


Ile Met Lys Gln Met Gln Asp Ala Lys Lys Ala Glu Thr Asp Lys Ile 
    210                 215                 220                 


Val Val Gly Ser Ser Val Ala Pro Gly Asn Thr Ala Pro Ser Pro Ser 
225                 230                 235                 240 


Ser Pro Thr Ser Pro Thr Ser Asp Ala Thr Thr Ser Leu Glu Met Asn 
                245                 250                 255     


Asn Pro His Ala Ile Pro Arg Arg His Ala Pro Ile Glu Gln Leu Ala 
            260                 265                 270         


Arg Gln Gly Ser Phe Arg Gly Phe Pro Ala Leu Ser Gln Lys Met Ser 
        275                 280                 285             


Pro Phe Lys Arg Gln Leu Ser Leu Arg Ile Asn Glu Leu Pro Ser Thr 
    290                 295                 300                 


Met Gln Arg Lys Thr Asp Phe Pro Ile Lys Asn Ala Val Pro Glu Val 
305                 310                 315                 320 


Glu Gly Glu Ala Glu Ser Ile Ser Ser Leu Cys Ser Gln Ile Thr Asn 
                325                 330                 335     


Ala Phe Ser Thr Pro Glu Asp Pro Phe Ser Ser Ala Pro Met Thr Lys 
            340                 345                 350         


Pro Val Thr Val Val Ala Pro Gln Ser Pro Thr Phe Gln Ala Asn Gly 
        355                 360                 365             


Thr Asp Ser Ala Phe His Val Leu Ala Lys Pro Ala His Thr Ala Leu 
    370                 375                 380                 


Ala Pro Val Ala Met Pro Val Arg Glu Thr Asn Pro Trp Ala His Ala 
385                 390                 395                 400 


Pro Asp Ala Ala Asn Lys Glu Ile Ala Ala Thr Cys Ser Gly Thr Glu 
                405                 410                 415     


Trp Gly Gln Ser Ser Gly Ala Ala Ser Pro Gly Leu Phe Gln Ala Gly 
            420                 425                 430         


His Arg Arg Thr Pro Ser Glu Ala Asp Arg Trp Leu Glu Glu Val Ser 
        435                 440                 445             


Lys Ser Val Arg Ala Gln Gln Pro Gln Ala Ser Ala Ala Pro Leu Gln 
    450                 455                 460                 


Pro Val Leu Gln Pro Pro Pro Pro Thr Ala Ile Ser Gln Pro Ala Ser 
465                 470                 475                 480 


Pro Phe Gln Gly Asn Ala Phe Leu Thr Ser Gln Pro Val Pro Val Gly 
                485                 490                 495     


Val Val Pro Ala Leu Gln Pro Ala Phe Val Pro Ala Gln Ser Tyr Pro 
            500                 505                 510         


Val Ala Asn Gly Met Pro Tyr Pro Ala Pro Asn Val Pro Val Val Gly 
        515                 520                 525             


Ile Thr Pro Ser Gln Met Val Ala Asn Val Phe Gly Thr Ala Gly His 
    530                 535                 540                 


Pro Gln Ala Ala His Pro His Gln Ser Pro Ser Leu Val Arg Gln Gln 
545                 550                 555                 560 


Thr Phe Pro His Tyr Glu Ala Ser Ser Ala Thr Thr Ser Pro Phe Phe 
                565                 570                 575     


Lys Pro Pro Ala Gln His Leu Asn Gly Ser Ala Ala Phe Asn Gly Val 
            580                 585                 590         


Asp Asp Gly Arg Leu Ala Ser Ala Asp Arg His Thr Glu Val Pro Thr 
        595                 600                 605             


Gly Thr Cys Pro Val Asp Pro Phe Glu Ala Gln Trp Ala Ala Leu Glu 
    610                 615                 620                 


Asn Lys Ser Lys Gln Arg Thr Asn Pro Ser Pro Thr Asn Pro Phe Ser 
625                 630                 635                 640 


Ser Asp Leu Gln Lys Thr Phe Glu Ile Glu Leu 
                645                 650     

<210>  459
<211>  3503
<212>  DNA
<213>  Homo sapiens

<400>  459
gttgtcatgg gggaggtggt ggcgcttggt ggccactggc ggccgaggta gaggcagtgg     60

cgcttgagtt ggtcgggggc agcggcagat ttgaggctta agcaacttct tccggggaag    120

agtgccagtg cagccactgt tacaattcaa gatcttgatc tatatccata gattggaata    180

ttggtgggcc agcaatcctc agacgcctca cttaggacaa atgaggaaac tgaggcttgg    240

tgaagttacg aaacttgtcc aaaatcacac aacttgtaaa gggcacagcc aagattcaga    300

gccaggctgt aaaaattaaa atgaacaaat tacggcaaag ttttaggaga aagaaggatg    360

tttatgttcc agaggccagt cgtccacatc agtggcagac agatgaagaa ggcgttcgca    420

ccggaaaatg tagcttcccg gttaagtacc ttggccatgt agaagttgat gaatcaagag    480

gaatgcacat ctgtgaagat gctgtaaaaa gattgaaagc tgaaaggaag ttcttcaaag    540

gcttctttgg aaaaactgga aagaaagcag ttaaagcagt tctgtgggtc tcagcagatg    600

gactcagagt tgtggatgaa aaaactaagg acctcatagt tgaccagacg atagagaaag    660

tttctttctg tgccccagac aggaactttg atagagcctt ttcttacata tgccgtgatg    720

gcaccactcg tcgctggatc tgtcactgct tcatggctgt caaggacaca ggtgaaaggt    780

tgagccatgc agtaggctgt gcttttgcag cctgtttaga gcgcaagcag aagcgggaga    840

aggaatgtgg agtgactgct acttttgatg ctagtcggac cacttttaca agagaaggat    900

cattccgtgt cacaacagcc actgaacaag cagaaagaga ggagatcatg aaacaaatgc    960

aagatgccaa gaaagctgaa acagataaga tagtcgttgg ttcatcagtt gcccctggca   1020

acactgcccc atccccatcc tctcccacct ctcctacttc tgatgccacg acctctctgg   1080

agatgaacaa tcctcatgcc atcccacgcc ggcatgctcc aattgaacag cttgctcgcc   1140

aaggctcttt ccgaggtttt cctgctctta gccagaagat gtcacccttt aaacgccaac   1200

tatccctacg catcaatgag ttgccttcca ctatgcagag gaagactgat ttccccatta   1260

aaaatgcagt gccagaagta gaaggggagg cagagagcat cagctccctg tgctcacaga   1320

tcaccaatgc cttcagcaca cctgaggacc ccttctcatc tgctccgatg accaaaccag   1380

tgacagtggt ggcaccacaa tctcctacct tccaagggac cgagtggggt caatcttctg   1440

gtgctgcctc tccaggtctc ttccaggccg gtcatagacg tactccctct gaggccgacc   1500

gatggttaga agaggtgtct aagagcgtcc gggctcagca gccccaggcc tcagctgctc   1560

ctctgcagcc agttctccag cctcctccac ccactgccat ctcccagcca gcatcacctt   1620

tccaagggaa tgcattcctc acctctcagc ctgtgccagt gggtgtggtc ccagccctgc   1680

aaccagcctt tgtccctgcc cagtcctatc ctgtggccaa tggaatgccc tatccagccc   1740

ctaatgtgcc tgtggtgggc atcactccct cccagatggt ggccaacgta tttggcactg   1800

caggccaccc tcaggctgcc catccccatc agtcacccag cctggtcagg cagcagacat   1860

tccctcacta cgaggcaagc agtgctacca ccagtccctt ctttaagcct cctgctcagc   1920

acctcaacgg ttctgcagct ttcaatggtg tagatgatgg caggttggcc tcagcagaca   1980

ggcatacaga ggttcctaca ggcacctgcc cagtggatcc ttttgaagcc cagtgggctg   2040

cattagaaaa taagtccaag cagcgtacta atccctcccc taccaaccct ttctccagtg   2100

acttacagaa gacgtttgaa attgaacttt aagcaatcat tatggctatg tatcttgtcc   2160

ataccagaca gggagcaggg ggtagcggtc aaaggagcaa aacagacttt gtctcctgat   2220

tagtactctt ttcactaatc ccaaaggtcc caaggaacaa gtccaggccc agagtactgt   2280

gaggggtgat tttgaaagac atgggaaaaa gcattcctag agaaaagctg ccttgcaatt   2340

aggctaaaga agtcaaggaa atgttgcttt ctgtactccc tcttccctta cccccttaca   2400

aatctctggc aacagagagg caaagtatct gaacaagaat ctatattcca agcacattta   2460

ctgaaatgta aaacacaaca ggaagcaaag caatctccct ttgtttttca ggccattcac   2520

ctgcctcctg tcagtagtgg cctgtattag agatcaagaa gagtggtttg tgctcaggct   2580

ggggaacaga gaggcacgct atgctgccag aattcccagg agggcatatc agcaactgcc   2640

cagcagagct atattttggg ggagaagttg agcttccatt ttgagtaaca gaataaatat   2700

tatatatatc aaaagccaaa atctttattt ttatgcattt agaatatttt aaatagttct   2760

cagatattaa gaagttgtat gagttgtaag taatcttgcc aaaggtaaag gggctagttg   2820

taagaaattg tacataagat tgatttatca ttgatgccta ctgaaataaa aagaggaaag   2880

gctggaagct gcagacagga tccctagctt gttttctgtc agtcattcat tgtaagtagc   2940

acattgcaac aacaatcatg cttatgacca atacagtcac taggttgtag ttttttttaa   3000

ataaaggaaa agcagtattg tcctggtttt aaacctatga tggaattcta atgtcattat   3060

tttaatggaa tcaatcgaaa tatgctctat agagaatata tcttttatat attgctgcag   3120

tttccttatg ttaatccttt aacactaagg taacatgaca taatcatacc atagaaggga   3180

acacaggtta ccatattggt ttgtaatatg ggtcttggtg ggttttgttt tatcctttaa   3240

attttgttcc catgagtttt gtggggatgg ggattctggt tttattagct ttgtgtgtgt   3300

cctcttcccc caaaccccct tttggtgaga acatcccctt gacagttgca gcctcttgac   3360

ctcggataac aataagagag ctcatctcat ttttactttt gaacgttggc cttacaatca   3420

aatgtaagtt atatatattt gtactgatga aaatttataa tctgctttaa caaaaataaa   3480

tgttcatggt agaagctttt aaa                                           3503


<210>  460
<211>  603
<212>  PRT
<213>  Homo sapiens

<400>  460


Met Asn Lys Leu Arg Gln Ser Phe Arg Arg Lys Lys Asp Val Tyr Val 
1               5                   10                  15      


Pro Glu Ala Ser Arg Pro His Gln Trp Gln Thr Asp Glu Glu Gly Val 
            20                  25                  30          


Arg Thr Gly Lys Cys Ser Phe Pro Val Lys Tyr Leu Gly His Val Glu 
        35                  40                  45              


Val Asp Glu Ser Arg Gly Met His Ile Cys Glu Asp Ala Val Lys Arg 
    50                  55                  60                  


Leu Lys Ala Glu Arg Lys Phe Phe Lys Gly Phe Phe Gly Lys Thr Gly 
65                  70                  75                  80  


Lys Lys Ala Val Lys Ala Val Leu Trp Val Ser Ala Asp Gly Leu Arg 
                85                  90                  95      


Val Val Asp Glu Lys Thr Lys Asp Leu Ile Val Asp Gln Thr Ile Glu 
            100                 105                 110         


Lys Val Ser Phe Cys Ala Pro Asp Arg Asn Phe Asp Arg Ala Phe Ser 
        115                 120                 125             


Tyr Ile Cys Arg Asp Gly Thr Thr Arg Arg Trp Ile Cys His Cys Phe 
    130                 135                 140                 


Met Ala Val Lys Asp Thr Gly Glu Arg Leu Ser His Ala Val Gly Cys 
145                 150                 155                 160 


Ala Phe Ala Ala Cys Leu Glu Arg Lys Gln Lys Arg Glu Lys Glu Cys 
                165                 170                 175     


Gly Val Thr Ala Thr Phe Asp Ala Ser Arg Thr Thr Phe Thr Arg Glu 
            180                 185                 190         


Gly Ser Phe Arg Val Thr Thr Ala Thr Glu Gln Ala Glu Arg Glu Glu 
        195                 200                 205             


Ile Met Lys Gln Met Gln Asp Ala Lys Lys Ala Glu Thr Asp Lys Ile 
    210                 215                 220                 


Val Val Gly Ser Ser Val Ala Pro Gly Asn Thr Ala Pro Ser Pro Ser 
225                 230                 235                 240 


Ser Pro Thr Ser Pro Thr Ser Asp Ala Thr Thr Ser Leu Glu Met Asn 
                245                 250                 255     


Asn Pro His Ala Ile Pro Arg Arg His Ala Pro Ile Glu Gln Leu Ala 
            260                 265                 270         


Arg Gln Gly Ser Phe Arg Gly Phe Pro Ala Leu Ser Gln Lys Met Ser 
        275                 280                 285             


Pro Phe Lys Arg Gln Leu Ser Leu Arg Ile Asn Glu Leu Pro Ser Thr 
    290                 295                 300                 


Met Gln Arg Lys Thr Asp Phe Pro Ile Lys Asn Ala Val Pro Glu Val 
305                 310                 315                 320 


Glu Gly Glu Ala Glu Ser Ile Ser Ser Leu Cys Ser Gln Ile Thr Asn 
                325                 330                 335     


Ala Phe Ser Thr Pro Glu Asp Pro Phe Ser Ser Ala Pro Met Thr Lys 
            340                 345                 350         


Pro Val Thr Val Val Ala Pro Gln Ser Pro Thr Phe Gln Gly Thr Glu 
        355                 360                 365             


Trp Gly Gln Ser Ser Gly Ala Ala Ser Pro Gly Leu Phe Gln Ala Gly 
    370                 375                 380                 


His Arg Arg Thr Pro Ser Glu Ala Asp Arg Trp Leu Glu Glu Val Ser 
385                 390                 395                 400 


Lys Ser Val Arg Ala Gln Gln Pro Gln Ala Ser Ala Ala Pro Leu Gln 
                405                 410                 415     


Pro Val Leu Gln Pro Pro Pro Pro Thr Ala Ile Ser Gln Pro Ala Ser 
            420                 425                 430         


Pro Phe Gln Gly Asn Ala Phe Leu Thr Ser Gln Pro Val Pro Val Gly 
        435                 440                 445             


Val Val Pro Ala Leu Gln Pro Ala Phe Val Pro Ala Gln Ser Tyr Pro 
    450                 455                 460                 


Val Ala Asn Gly Met Pro Tyr Pro Ala Pro Asn Val Pro Val Val Gly 
465                 470                 475                 480 


Ile Thr Pro Ser Gln Met Val Ala Asn Val Phe Gly Thr Ala Gly His 
                485                 490                 495     


Pro Gln Ala Ala His Pro His Gln Ser Pro Ser Leu Val Arg Gln Gln 
            500                 505                 510         


Thr Phe Pro His Tyr Glu Ala Ser Ser Ala Thr Thr Ser Pro Phe Phe 
        515                 520                 525             


Lys Pro Pro Ala Gln His Leu Asn Gly Ser Ala Ala Phe Asn Gly Val 
    530                 535                 540                 


Asp Asp Gly Arg Leu Ala Ser Ala Asp Arg His Thr Glu Val Pro Thr 
545                 550                 555                 560 


Gly Thr Cys Pro Val Asp Pro Phe Glu Ala Gln Trp Ala Ala Leu Glu 
                565                 570                 575     


Asn Lys Ser Lys Gln Arg Thr Asn Pro Ser Pro Thr Asn Pro Phe Ser 
            580                 585                 590         


Ser Asp Leu Gln Lys Thr Phe Glu Ile Glu Leu 
        595                 600             

<210>  461
<211>  3470
<212>  DNA
<213>  Homo sapiens

<400>  461
gttgtcatgg gggaggtggt ggcgcttggt ggccactggc ggccgaggta gaggcagtgg     60

cgcttgagtt ggtcgggggc agcggcagat ttgaggctta agcaacttct tccggggaag    120

agtgccagtg cagccactgt tacaattcaa gatcttgatc tatatccata gattggaata    180

ttggtgggcc agcaatcctc agacgcctca cttaggacaa atgaggaaac tgaggcttgg    240

tgaagttacg aaacttgtcc aaaatcacac aacttgtaaa gggcacagcc aagattcaga    300

gccaggctgt aaaaattaaa atgaacaaat tacggcaaag ttttaggaga aagaaggatg    360

tttatgttcc agaggccagt cgtccacatc agtggcagac agatgaagaa ggcgttcgca    420

ccggaaaatg tagcttcccg gttaagtacc ttggccatgt agaagttgat gaatcaagag    480

gaatgcacat ctgtgaagat gctgtaaaaa gattgaaagc tactggaaag aaagcagtta    540

aagcagttct gtgggtctca gcagatggac tcagagttgt ggatgaaaaa actaaggacc    600

tcatagttga ccagacgata gagaaagttt ctttctgtgc cccagacagg aactttgata    660

gagccttttc ttacatatgc cgtgatggca ccactcgtcg ctggatctgt cactgcttca    720

tggctgtcaa ggacacaggt gaaaggttga gccatgcagt aggctgtgct tttgcagcct    780

gtttagagcg caagcagaag cgggagaagg aatgtggagt gactgctact tttgatgcta    840

gtcggaccac ttttacaaga gaaggatcat tccgtgtcac aacagccact gaacaagcag    900

aaagagagga gatcatgaaa caaatgcaag atgccaagaa agctgaaaca gataagatag    960

tcgttggttc atcagttgcc cctggcaaca ctgccccatc cccatcctct cccacctctc   1020

ctacttctga tgccacgacc tctctggaga tgaacaatcc tcatgccatc ccacgccggc   1080

atgctccaat tgaacagctt gctcgccaag gctctttccg aggttttcct gctcttagcc   1140

agaagatgtc accctttaaa cgccaactat ccctacgcat caatgagttg ccttccacta   1200

tgcagaggaa gactgatttc cccattaaaa atgcagtgcc agaagtagaa ggggaggcag   1260

agagcatcag ctccctgtgc tcacagatca ccaatgcctt cagcacacct gaggacccct   1320

tctcatctgc tccgatgacc aaaccagtga cagtggtggc accacaatct cctaccttcc   1380

aagggaccga gtggggtcaa tcttctggtg ctgcctctcc aggtctcttc caggccggtc   1440

atagacgtac tccctctgag gccgaccgat ggttagaaga ggtgtctaag agcgtccggg   1500

ctcagcagcc ccaggcctca gctgctcctc tgcagccagt tctccagcct cctccaccca   1560

ctgccatctc ccagccagca tcacctttcc aagggaatgc attcctcacc tctcagcctg   1620

tgccagtggg tgtggtccca gccctgcaac cagcctttgt ccctgcccag tcctatcctg   1680

tggccaatgg aatgccctat ccagccccta atgtgcctgt ggtgggcatc actccctccc   1740

agatggtggc caacgtattt ggcactgcag gccaccctca ggctgcccat ccccatcagt   1800

cacccagcct ggtcaggcag cagacattcc ctcactacga ggcaagcagt gctaccacca   1860

gtcccttctt taagcctcct gctcagcacc tcaacggttc tgcagctttc aatggtgtag   1920

atgatggcag gttggcctca gcagacaggc atacagaggt tcctacaggc acctgcccag   1980

tggatccttt tgaagcccag tgggctgcat tagaaaataa gtccaagcag cgtactaatc   2040

cctcccctac caaccctttc tccagtgact tacagaagac gtttgaaatt gaactttaag   2100

caatcattat ggctatgtat cttgtccata ccagacaggg agcagggggt agcggtcaaa   2160

ggagcaaaac agactttgtc tcctgattag tactcttttc actaatccca aaggtcccaa   2220

ggaacaagtc caggcccaga gtactgtgag gggtgatttt gaaagacatg ggaaaaagca   2280

ttcctagaga aaagctgcct tgcaattagg ctaaagaagt caaggaaatg ttgctttctg   2340

tactccctct tcccttaccc ccttacaaat ctctggcaac agagaggcaa agtatctgaa   2400

caagaatcta tattccaagc acatttactg aaatgtaaaa cacaacagga agcaaagcaa   2460

tctccctttg tttttcaggc cattcacctg cctcctgtca gtagtggcct gtattagaga   2520

tcaagaagag tggtttgtgc tcaggctggg gaacagagag gcacgctatg ctgccagaat   2580

tcccaggagg gcatatcagc aactgcccag cagagctata ttttggggga gaagttgagc   2640

ttccattttg agtaacagaa taaatattat atatatcaaa agccaaaatc tttattttta   2700

tgcatttaga atattttaaa tagttctcag atattaagaa gttgtatgag ttgtaagtaa   2760

tcttgccaaa ggtaaagggg ctagttgtaa gaaattgtac ataagattga tttatcattg   2820

atgcctactg aaataaaaag aggaaaggct ggaagctgca gacaggatcc ctagcttgtt   2880

ttctgtcagt cattcattgt aagtagcaca ttgcaacaac aatcatgctt atgaccaata   2940

cagtcactag gttgtagttt tttttaaata aaggaaaagc agtattgtcc tggttttaaa   3000

cctatgatgg aattctaatg tcattatttt aatggaatca atcgaaatat gctctataga   3060

gaatatatct tttatatatt gctgcagttt ccttatgtta atcctttaac actaaggtaa   3120

catgacataa tcataccata gaagggaaca caggttacca tattggtttg taatatgggt   3180

cttggtgggt tttgttttat cctttaaatt ttgttcccat gagttttgtg gggatgggga   3240

ttctggtttt attagctttg tgtgtgtcct cttcccccaa accccctttt ggtgagaaca   3300

tccccttgac agttgcagcc tcttgacctc ggataacaat aagagagctc atctcatttt   3360

tacttttgaa cgttggcctt acaatcaaat gtaagttata tatatttgta ctgatgaaaa   3420

tttataatct gctttaacaa aaataaatgt tcatggtaga agcttttaaa              3470


<210>  462
<211>  592
<212>  PRT
<213>  Homo sapiens

<400>  462


Met Asn Lys Leu Arg Gln Ser Phe Arg Arg Lys Lys Asp Val Tyr Val 
1               5                   10                  15      


Pro Glu Ala Ser Arg Pro His Gln Trp Gln Thr Asp Glu Glu Gly Val 
            20                  25                  30          


Arg Thr Gly Lys Cys Ser Phe Pro Val Lys Tyr Leu Gly His Val Glu 
        35                  40                  45              


Val Asp Glu Ser Arg Gly Met His Ile Cys Glu Asp Ala Val Lys Arg 
    50                  55                  60                  


Leu Lys Ala Thr Gly Lys Lys Ala Val Lys Ala Val Leu Trp Val Ser 
65                  70                  75                  80  


Ala Asp Gly Leu Arg Val Val Asp Glu Lys Thr Lys Asp Leu Ile Val 
                85                  90                  95      


Asp Gln Thr Ile Glu Lys Val Ser Phe Cys Ala Pro Asp Arg Asn Phe 
            100                 105                 110         


Asp Arg Ala Phe Ser Tyr Ile Cys Arg Asp Gly Thr Thr Arg Arg Trp 
        115                 120                 125             


Ile Cys His Cys Phe Met Ala Val Lys Asp Thr Gly Glu Arg Leu Ser 
    130                 135                 140                 


His Ala Val Gly Cys Ala Phe Ala Ala Cys Leu Glu Arg Lys Gln Lys 
145                 150                 155                 160 


Arg Glu Lys Glu Cys Gly Val Thr Ala Thr Phe Asp Ala Ser Arg Thr 
                165                 170                 175     


Thr Phe Thr Arg Glu Gly Ser Phe Arg Val Thr Thr Ala Thr Glu Gln 
            180                 185                 190         


Ala Glu Arg Glu Glu Ile Met Lys Gln Met Gln Asp Ala Lys Lys Ala 
        195                 200                 205             


Glu Thr Asp Lys Ile Val Val Gly Ser Ser Val Ala Pro Gly Asn Thr 
    210                 215                 220                 


Ala Pro Ser Pro Ser Ser Pro Thr Ser Pro Thr Ser Asp Ala Thr Thr 
225                 230                 235                 240 


Ser Leu Glu Met Asn Asn Pro His Ala Ile Pro Arg Arg His Ala Pro 
                245                 250                 255     


Ile Glu Gln Leu Ala Arg Gln Gly Ser Phe Arg Gly Phe Pro Ala Leu 
            260                 265                 270         


Ser Gln Lys Met Ser Pro Phe Lys Arg Gln Leu Ser Leu Arg Ile Asn 
        275                 280                 285             


Glu Leu Pro Ser Thr Met Gln Arg Lys Thr Asp Phe Pro Ile Lys Asn 
    290                 295                 300                 


Ala Val Pro Glu Val Glu Gly Glu Ala Glu Ser Ile Ser Ser Leu Cys 
305                 310                 315                 320 


Ser Gln Ile Thr Asn Ala Phe Ser Thr Pro Glu Asp Pro Phe Ser Ser 
                325                 330                 335     


Ala Pro Met Thr Lys Pro Val Thr Val Val Ala Pro Gln Ser Pro Thr 
            340                 345                 350         


Phe Gln Gly Thr Glu Trp Gly Gln Ser Ser Gly Ala Ala Ser Pro Gly 
        355                 360                 365             


Leu Phe Gln Ala Gly His Arg Arg Thr Pro Ser Glu Ala Asp Arg Trp 
    370                 375                 380                 


Leu Glu Glu Val Ser Lys Ser Val Arg Ala Gln Gln Pro Gln Ala Ser 
385                 390                 395                 400 


Ala Ala Pro Leu Gln Pro Val Leu Gln Pro Pro Pro Pro Thr Ala Ile 
                405                 410                 415     


Ser Gln Pro Ala Ser Pro Phe Gln Gly Asn Ala Phe Leu Thr Ser Gln 
            420                 425                 430         


Pro Val Pro Val Gly Val Val Pro Ala Leu Gln Pro Ala Phe Val Pro 
        435                 440                 445             


Ala Gln Ser Tyr Pro Val Ala Asn Gly Met Pro Tyr Pro Ala Pro Asn 
    450                 455                 460                 


Val Pro Val Val Gly Ile Thr Pro Ser Gln Met Val Ala Asn Val Phe 
465                 470                 475                 480 


Gly Thr Ala Gly His Pro Gln Ala Ala His Pro His Gln Ser Pro Ser 
                485                 490                 495     


Leu Val Arg Gln Gln Thr Phe Pro His Tyr Glu Ala Ser Ser Ala Thr 
            500                 505                 510         


Thr Ser Pro Phe Phe Lys Pro Pro Ala Gln His Leu Asn Gly Ser Ala 
        515                 520                 525             


Ala Phe Asn Gly Val Asp Asp Gly Arg Leu Ala Ser Ala Asp Arg His 
    530                 535                 540                 


Thr Glu Val Pro Thr Gly Thr Cys Pro Val Asp Pro Phe Glu Ala Gln 
545                 550                 555                 560 


Trp Ala Ala Leu Glu Asn Lys Ser Lys Gln Arg Thr Asn Pro Ser Pro 
                565                 570                 575     


Thr Asn Pro Phe Ser Ser Asp Leu Gln Lys Thr Phe Glu Ile Glu Leu 
            580                 585                 590         

<210>  463
<211>  3614
<212>  DNA
<213>  Homo sapiens

<400>  463
gttgtcatgg gggaggtggt ggcgcttggt ggccactggc ggccgaggta gaggcagtgg     60

cgcttgagtt ggtcgggggc agcggcagat ttgaggctta agcaacttct tccggggaag    120

agtgccagtg cagccactgt tacaattcaa gatcttgatc tatatccata gattggaata    180

ttggtgggcc agcaatcctc agacgcctca cttaggacaa atgaggaaac tgaggcttgg    240

tgaagttacg aaacttgtcc aaaatcacac aacttgtaaa gggcacagcc aagattcaga    300

gccaggctgt aaaaattaaa atgaacaaat tacggcaaag ttttaggaga aagaaggatg    360

tttatgttcc agaggccagt cgtccacatc agtggcagac agatgaagaa ggcgttcgca    420

ccggaaaatg tagcttcccg gttaagtacc ttggccatgt agaagttgat gaatcaagag    480

gaatgcacat ctgtgaagat gctgtaaaaa gattgaaagc tactggaaag aaagcagtta    540

aagcagttct gtgggtctca gcagatggac tcagagttgt ggatgaaaaa actaaggacc    600

tcatagttga ccagacgata gagaaagttt ctttctgtgc cccagacagg aactttgata    660

gagccttttc ttacatatgc cgtgatggca ccactcgtcg ctggatctgt cactgcttca    720

tggctgtcaa ggacacaggt gaaaggttga gccatgcagt aggctgtgct tttgcagcct    780

gtttagagcg caagcagaag cgggagaagg aatgtggagt gactgctact tttgatgcta    840

gtcggaccac ttttacaaga gaaggatcat tccgtgtcac aacagccact gaacaagcag    900

aaagagagga gatcatgaaa caaatgcaag atgccaagaa agctgaaaca gataagatag    960

tcgttggttc atcagttgcc cctggcaaca ctgccccatc cccatcctct cccacctctc   1020

ctacttctga tgccacgacc tctctggaga tgaacaatcc tcatgccatc ccacgccggc   1080

atgctccaat tgaacagctt gctcgccaag gctctttccg aggttttcct gctcttagcc   1140

agaagatgtc accctttaaa cgccaactat ccctacgcat caatgagttg ccttccacta   1200

tgcagaggaa gactgatttc cccattaaaa atgcagtgcc agaagtagaa ggggaggcag   1260

agagcatcag ctccctgtgc tcacagatca ccaatgcctt cagcacacct gaggacccct   1320

tctcatctgc tccgatgacc aaaccagtga cagtggtggc accacaatct cctaccttcc   1380

aagctaatgg cactgactca gccttccatg tgcttgctaa gccagcccat actgctctag   1440

cacccgtagc aatgcctgtg cgtgaaacca acccttgggc ccatgcccct gatgctgcta   1500

acaaggaaat tgcagccaca tgttcgggga ccgagtgggg tcaatcttct ggtgctgcct   1560

ctccaggtct cttccaggcc ggtcatagac gtactccctc tgaggccgac cgatggttag   1620

aagaggtgtc taagagcgtc cgggctcagc agccccaggc ctcagctgct cctctgcagc   1680

cagttctcca gcctcctcca cccactgcca tctcccagcc agcatcacct ttccaaggga   1740

atgcattcct cacctctcag cctgtgccag tgggtgtggt cccagccctg caaccagcct   1800

ttgtccctgc ccagtcctat cctgtggcca atggaatgcc ctatccagcc cctaatgtgc   1860

ctgtggtggg catcactccc tcccagatgg tggccaacgt atttggcact gcaggccacc   1920

ctcaggctgc ccatccccat cagtcaccca gcctggtcag gcagcagaca ttccctcact   1980

acgaggcaag cagtgctacc accagtccct tctttaagcc tcctgctcag cacctcaacg   2040

gttctgcagc tttcaatggt gtagatgatg gcaggttggc ctcagcagac aggcatacag   2100

aggttcctac aggcacctgc ccagtggatc cttttgaagc ccagtgggct gcattagaaa   2160

ataagtccaa gcagcgtact aatccctccc ctaccaaccc tttctccagt gacttacaga   2220

agacgtttga aattgaactt taagcaatca ttatggctat gtatcttgtc cataccagac   2280

agggagcagg gggtagcggt caaaggagca aaacagactt tgtctcctga ttagtactct   2340

tttcactaat cccaaaggtc ccaaggaaca agtccaggcc cagagtactg tgaggggtga   2400

ttttgaaaga catgggaaaa agcattccta gagaaaagct gccttgcaat taggctaaag   2460

aagtcaagga aatgttgctt tctgtactcc ctcttccctt acccccttac aaatctctgg   2520

caacagagag gcaaagtatc tgaacaagaa tctatattcc aagcacattt actgaaatgt   2580

aaaacacaac aggaagcaaa gcaatctccc tttgtttttc aggccattca cctgcctcct   2640

gtcagtagtg gcctgtatta gagatcaaga agagtggttt gtgctcaggc tggggaacag   2700

agaggcacgc tatgctgcca gaattcccag gagggcatat cagcaactgc ccagcagagc   2760

tatattttgg gggagaagtt gagcttccat tttgagtaac agaataaata ttatatatat   2820

caaaagccaa aatctttatt tttatgcatt tagaatattt taaatagttc tcagatatta   2880

agaagttgta tgagttgtaa gtaatcttgc caaaggtaaa ggggctagtt gtaagaaatt   2940

gtacataaga ttgatttatc attgatgcct actgaaataa aaagaggaaa ggctggaagc   3000

tgcagacagg atccctagct tgttttctgt cagtcattca ttgtaagtag cacattgcaa   3060

caacaatcat gcttatgacc aatacagtca ctaggttgta gtttttttta aataaaggaa   3120

aagcagtatt gtcctggttt taaacctatg atggaattct aatgtcatta ttttaatgga   3180

atcaatcgaa atatgctcta tagagaatat atcttttata tattgctgca gtttccttat   3240

gttaatcctt taacactaag gtaacatgac ataatcatac catagaaggg aacacaggtt   3300

accatattgg tttgtaatat gggtcttggt gggttttgtt ttatccttta aattttgttc   3360

ccatgagttt tgtggggatg gggattctgg ttttattagc tttgtgtgtg tcctcttccc   3420

ccaaaccccc ttttggtgag aacatcccct tgacagttgc agcctcttga cctcggataa   3480

caataagaga gctcatctca tttttacttt tgaacgttgg ccttacaatc aaatgtaagt   3540

tatatatatt tgtactgatg aaaatttata atctgcttta acaaaaataa atgttcatgg   3600

tagaagcttt taaa                                                     3614


<210>  464
<211>  640
<212>  PRT
<213>  Homo sapiens

<400>  464


Met Asn Lys Leu Arg Gln Ser Phe Arg Arg Lys Lys Asp Val Tyr Val 
1               5                   10                  15      


Pro Glu Ala Ser Arg Pro His Gln Trp Gln Thr Asp Glu Glu Gly Val 
            20                  25                  30          


Arg Thr Gly Lys Cys Ser Phe Pro Val Lys Tyr Leu Gly His Val Glu 
        35                  40                  45              


Val Asp Glu Ser Arg Gly Met His Ile Cys Glu Asp Ala Val Lys Arg 
    50                  55                  60                  


Leu Lys Ala Thr Gly Lys Lys Ala Val Lys Ala Val Leu Trp Val Ser 
65                  70                  75                  80  


Ala Asp Gly Leu Arg Val Val Asp Glu Lys Thr Lys Asp Leu Ile Val 
                85                  90                  95      


Asp Gln Thr Ile Glu Lys Val Ser Phe Cys Ala Pro Asp Arg Asn Phe 
            100                 105                 110         


Asp Arg Ala Phe Ser Tyr Ile Cys Arg Asp Gly Thr Thr Arg Arg Trp 
        115                 120                 125             


Ile Cys His Cys Phe Met Ala Val Lys Asp Thr Gly Glu Arg Leu Ser 
    130                 135                 140                 


His Ala Val Gly Cys Ala Phe Ala Ala Cys Leu Glu Arg Lys Gln Lys 
145                 150                 155                 160 


Arg Glu Lys Glu Cys Gly Val Thr Ala Thr Phe Asp Ala Ser Arg Thr 
                165                 170                 175     


Thr Phe Thr Arg Glu Gly Ser Phe Arg Val Thr Thr Ala Thr Glu Gln 
            180                 185                 190         


Ala Glu Arg Glu Glu Ile Met Lys Gln Met Gln Asp Ala Lys Lys Ala 
        195                 200                 205             


Glu Thr Asp Lys Ile Val Val Gly Ser Ser Val Ala Pro Gly Asn Thr 
    210                 215                 220                 


Ala Pro Ser Pro Ser Ser Pro Thr Ser Pro Thr Ser Asp Ala Thr Thr 
225                 230                 235                 240 


Ser Leu Glu Met Asn Asn Pro His Ala Ile Pro Arg Arg His Ala Pro 
                245                 250                 255     


Ile Glu Gln Leu Ala Arg Gln Gly Ser Phe Arg Gly Phe Pro Ala Leu 
            260                 265                 270         


Ser Gln Lys Met Ser Pro Phe Lys Arg Gln Leu Ser Leu Arg Ile Asn 
        275                 280                 285             


Glu Leu Pro Ser Thr Met Gln Arg Lys Thr Asp Phe Pro Ile Lys Asn 
    290                 295                 300                 


Ala Val Pro Glu Val Glu Gly Glu Ala Glu Ser Ile Ser Ser Leu Cys 
305                 310                 315                 320 


Ser Gln Ile Thr Asn Ala Phe Ser Thr Pro Glu Asp Pro Phe Ser Ser 
                325                 330                 335     


Ala Pro Met Thr Lys Pro Val Thr Val Val Ala Pro Gln Ser Pro Thr 
            340                 345                 350         


Phe Gln Ala Asn Gly Thr Asp Ser Ala Phe His Val Leu Ala Lys Pro 
        355                 360                 365             


Ala His Thr Ala Leu Ala Pro Val Ala Met Pro Val Arg Glu Thr Asn 
    370                 375                 380                 


Pro Trp Ala His Ala Pro Asp Ala Ala Asn Lys Glu Ile Ala Ala Thr 
385                 390                 395                 400 


Cys Ser Gly Thr Glu Trp Gly Gln Ser Ser Gly Ala Ala Ser Pro Gly 
                405                 410                 415     


Leu Phe Gln Ala Gly His Arg Arg Thr Pro Ser Glu Ala Asp Arg Trp 
            420                 425                 430         


Leu Glu Glu Val Ser Lys Ser Val Arg Ala Gln Gln Pro Gln Ala Ser 
        435                 440                 445             


Ala Ala Pro Leu Gln Pro Val Leu Gln Pro Pro Pro Pro Thr Ala Ile 
    450                 455                 460                 


Ser Gln Pro Ala Ser Pro Phe Gln Gly Asn Ala Phe Leu Thr Ser Gln 
465                 470                 475                 480 


Pro Val Pro Val Gly Val Val Pro Ala Leu Gln Pro Ala Phe Val Pro 
                485                 490                 495     


Ala Gln Ser Tyr Pro Val Ala Asn Gly Met Pro Tyr Pro Ala Pro Asn 
            500                 505                 510         


Val Pro Val Val Gly Ile Thr Pro Ser Gln Met Val Ala Asn Val Phe 
        515                 520                 525             


Gly Thr Ala Gly His Pro Gln Ala Ala His Pro His Gln Ser Pro Ser 
    530                 535                 540                 


Leu Val Arg Gln Gln Thr Phe Pro His Tyr Glu Ala Ser Ser Ala Thr 
545                 550                 555                 560 


Thr Ser Pro Phe Phe Lys Pro Pro Ala Gln His Leu Asn Gly Ser Ala 
                565                 570                 575     


Ala Phe Asn Gly Val Asp Asp Gly Arg Leu Ala Ser Ala Asp Arg His 
            580                 585                 590         


Thr Glu Val Pro Thr Gly Thr Cys Pro Val Asp Pro Phe Glu Ala Gln 
        595                 600                 605             


Trp Ala Ala Leu Glu Asn Lys Ser Lys Gln Arg Thr Asn Pro Ser Pro 
    610                 615                 620                 


Thr Asn Pro Phe Ser Ser Asp Leu Gln Lys Thr Phe Glu Ile Glu Leu 
625                 630                 635                 640 

<210>  465
<211>  1101
<212>  DNA
<213>  Homo sapiens

<400>  465
acttagagcg ccgaacagct ctgggccaaa ggaccatgag agggccggag ccgggtcccc     60

aaccgacgat ggagggagac gtgctggaca cactggaggc gctggggtat aaaggaccat    120

tgttagaaga gcaagccctt acaaaggcgg cagagggtgg attatcttca cctgaatttt    180

cagagctctg tatttggtta ggctctcaaa taaaatcatt atgcaacttg gaagaaagta    240

tcacgtctgc tggaagagat gatctagaga gcttccagct tgagataagt ggctttttaa    300

aagaaatggc atgtccatat tctgtactca tatcaggaga tattaaagat cgtttaaaaa    360

agaaggagga ctgtttgaaa cttctattat ttttaagtac agaacttcaa gcttcacaga    420

tattacagaa caagaaacat aaaaattctc aattagataa aaatagtgaa gtttatcagg    480

aagttcaagc tatgtttgat acacttggta tacccaagtc aacaacttct gacattccgc    540

atatgctaaa ccaagtggaa tcaaaggtga aagatattct ctcaaaggtc cagaaaaatc    600

atgtgggaaa accactgctg aaaatggatt taaattcaga acaggcggaa caactggaaa    660

gaatcaatga tgctctttcc tgtgaatatg agtgccgccg acgaatgtta atgaaacgat    720

tagatgtgac tgtacagtcc tttggatggt ctgatagagc aaaggtaaaa acagatgata    780

tagcaagaat ttatcagcct aagcgttatg ctttgtcacc caagacaacg attacaatgg    840

cacatctact tgctgctcgt gaagatctat ccaagatcat taggacaagt agtggcacca    900

gccgggagaa gaccgcatgt gccattaata aggttggtgt ttctttcagt acagtggaaa    960

atgaattgat gatatcttac ttaatgtttt tacagatttt agtctatttt tctttcatgt   1020

cctggtaaat gtttagaaaa aagagtggca ggggggttca gtctaggctt agttatgtta   1080

tttttgtgta tgtgtgtatg t                                             1101


<210>  466
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  466


Met Arg Gly Pro Glu Pro Gly Pro Gln Pro Thr Met Glu Gly Asp Val 
1               5                   10                  15      


Leu Asp Thr Leu Glu Ala Leu Gly Tyr Lys Gly Pro Leu Leu Glu Glu 
            20                  25                  30          


Gln Ala Leu Thr Lys Ala Ala Glu Gly Gly Leu Ser Ser Pro Glu Phe 
        35                  40                  45              


Ser Glu Leu Cys Ile Trp Leu Gly Ser Gln Ile Lys Ser Leu Cys Asn 
    50                  55                  60                  


Leu Glu Glu Ser Ile Thr Ser Ala Gly Arg Asp Asp Leu Glu Ser Phe 
65                  70                  75                  80  


Gln Leu Glu Ile Ser Gly Phe Leu Lys Glu Met Ala Cys Pro Tyr Ser 
                85                  90                  95      


Val Leu Ile Ser Gly Asp Ile Lys Asp Arg Leu Lys Lys Lys Glu Asp 
            100                 105                 110         


Cys Leu Lys Leu Leu Leu Phe Leu Ser Thr Glu Leu Gln Ala Ser Gln 
        115                 120                 125             


Ile Leu Gln Asn Lys Lys His Lys Asn Ser Gln Leu Asp Lys Asn Ser 
    130                 135                 140                 


Glu Val Tyr Gln Glu Val Gln Ala Met Phe Asp Thr Leu Gly Ile Pro 
145                 150                 155                 160 


Lys Ser Thr Thr Ser Asp Ile Pro His Met Leu Asn Gln Val Glu Ser 
                165                 170                 175     


Lys Val Lys Asp Ile Leu Ser Lys Val Gln Lys Asn His Val Gly Lys 
            180                 185                 190         


Pro Leu Leu Lys Met Asp Leu Asn Ser Glu Gln Ala Glu Gln Leu Glu 
        195                 200                 205             


Arg Ile Asn Asp Ala Leu Ser Cys Glu Tyr Glu Cys Arg Arg Arg Met 
    210                 215                 220                 


Leu Met Lys Arg Leu Asp Val Thr Val Gln Ser Phe Gly Trp Ser Asp 
225                 230                 235                 240 


Arg Ala Lys Val Lys Thr Asp Asp Ile Ala Arg Ile Tyr Gln Pro Lys 
                245                 250                 255     


Arg Tyr Ala Leu Ser Pro Lys Thr Thr Ile Thr Met Ala His Leu Leu 
            260                 265                 270         


Ala Ala Arg Glu Asp Leu Ser Lys Ile Ile Arg Thr Ser Ser Gly Thr 
        275                 280                 285             


Ser Arg Glu Lys Thr Ala Cys Ala Ile Asn Lys Val Gly Val Ser Phe 
    290                 295                 300                 


Ser Thr Val Glu Asn Glu Leu Met Ile Ser Tyr Leu Met Phe Leu Gln 
305                 310                 315                 320 


Ile Leu Val Tyr Phe Ser Phe Met Ser Trp 
                325                 330 

<210>  467
<211>  1556
<212>  DNA
<213>  Homo sapiens

<400>  467
acttagagcg ccgaacagct ctgggccaaa ggaccatgag agggccggag ccgggtcccc     60

aaccgacgat ggagggagac gtgctggaca cactggaggc gctggggtat aaaggaccat    120

tgttagaaga gcaagccctt acaaaggcgg cagagggtgg attatcttca cctgaatttt    180

cagagctctg tatttggtta ggctctcaaa taaaatcatt atgcaacttg gaagaaagta    240

tcacgtctgc tggaagagat gatctagaga gcttccagct tgagataagt ggctttttaa    300

aagaaatggc atgtccatat tctgtactca tatcaggaga tattaaagat cgtttaaaaa    360

agaaggagga ctgtttgaaa cttctattat ttttaagtac agaacttcaa gcttcacaga    420

tattacagaa caagaaacat aaaaattctc aattagataa aaatagtgaa gtttatcagg    480

aagttcaagc tatgtttgat acacttggta tacccaagtc aacaacttct gacattccgc    540

atatgctaaa ccaagtggaa tcaaaggtga aagatattct ctcaaaggtc cagaaaaatc    600

atgtgggaaa accactgctg aaaatggatt taaattcaga acaggcggaa caactggaaa    660

gaatcaatga tgctctttcc tgtgaatatg agtgccgccg acgaatgtta atgaaacgat    720

tagatgtgac tgtacagtcc tttggatggt ctgatagagc aaaggtaaaa acagatgata    780

tagcaagaat ttatcagcct aagcgttatg ctttgtcacc caagacaacg attacaatgg    840

cacatctact tgctgctcgt gaagatctat ccaagatcat taggacaagt agtggcacca    900

gccgggagaa gaccgcatgt gccattaata aggtgctgat gggaagggtg cctgacaggg    960

gaggccggcc gaatgaaatt gaaccaccac ctccagaaat gcccccttgg caaaagagac   1020

aagaaggcgg cggtggaagg ggtggttggg gtggtggtgg tggaggtggt ggtagaggag   1080

gtggtggggg tgggggtggg agaggtggct gggggggtgg aggaggaggt tggggaggtg   1140

gtgggggagg gggaggaggg tgggggggag gaggaggagg tggtagagga ggtttccaag   1200

gcaggggaga ttatggtgga agagggggtt atggtggaag agggggctat ggtggaagag   1260

gctatggaga tccatatgga ggaggtggtg gtggtggtgg tggtggtggt ggaggaggtg   1320

gatatagaag atactaaaaa ctataaaaat tagatagcag tgcttgcttc tttatagata   1380

cattagaaat agtgttccaa ataacatact tgaatatcat ctttgaagta aacaccatgt   1440

tagactccct ggtgatacca ctcttgaatt ggttaatatg taagaacatt gttttttatt   1500

accagttgat ctctcaaatg aagtgatgac tttttccata aaaaaaaaaa aaaaaa       1556


<210>  468
<211>  433
<212>  PRT
<213>  Homo sapiens

<400>  468


Met Arg Gly Pro Glu Pro Gly Pro Gln Pro Thr Met Glu Gly Asp Val 
1               5                   10                  15      


Leu Asp Thr Leu Glu Ala Leu Gly Tyr Lys Gly Pro Leu Leu Glu Glu 
            20                  25                  30          


Gln Ala Leu Thr Lys Ala Ala Glu Gly Gly Leu Ser Ser Pro Glu Phe 
        35                  40                  45              


Ser Glu Leu Cys Ile Trp Leu Gly Ser Gln Ile Lys Ser Leu Cys Asn 
    50                  55                  60                  


Leu Glu Glu Ser Ile Thr Ser Ala Gly Arg Asp Asp Leu Glu Ser Phe 
65                  70                  75                  80  


Gln Leu Glu Ile Ser Gly Phe Leu Lys Glu Met Ala Cys Pro Tyr Ser 
                85                  90                  95      


Val Leu Ile Ser Gly Asp Ile Lys Asp Arg Leu Lys Lys Lys Glu Asp 
            100                 105                 110         


Cys Leu Lys Leu Leu Leu Phe Leu Ser Thr Glu Leu Gln Ala Ser Gln 
        115                 120                 125             


Ile Leu Gln Asn Lys Lys His Lys Asn Ser Gln Leu Asp Lys Asn Ser 
    130                 135                 140                 


Glu Val Tyr Gln Glu Val Gln Ala Met Phe Asp Thr Leu Gly Ile Pro 
145                 150                 155                 160 


Lys Ser Thr Thr Ser Asp Ile Pro His Met Leu Asn Gln Val Glu Ser 
                165                 170                 175     


Lys Val Lys Asp Ile Leu Ser Lys Val Gln Lys Asn His Val Gly Lys 
            180                 185                 190         


Pro Leu Leu Lys Met Asp Leu Asn Ser Glu Gln Ala Glu Gln Leu Glu 
        195                 200                 205             


Arg Ile Asn Asp Ala Leu Ser Cys Glu Tyr Glu Cys Arg Arg Arg Met 
    210                 215                 220                 


Leu Met Lys Arg Leu Asp Val Thr Val Gln Ser Phe Gly Trp Ser Asp 
225                 230                 235                 240 


Arg Ala Lys Val Lys Thr Asp Asp Ile Ala Arg Ile Tyr Gln Pro Lys 
                245                 250                 255     


Arg Tyr Ala Leu Ser Pro Lys Thr Thr Ile Thr Met Ala His Leu Leu 
            260                 265                 270         


Ala Ala Arg Glu Asp Leu Ser Lys Ile Ile Arg Thr Ser Ser Gly Thr 
        275                 280                 285             


Ser Arg Glu Lys Thr Ala Cys Ala Ile Asn Lys Val Leu Met Gly Arg 
    290                 295                 300                 


Val Pro Asp Arg Gly Gly Arg Pro Asn Glu Ile Glu Pro Pro Pro Pro 
305                 310                 315                 320 


Glu Met Pro Pro Trp Gln Lys Arg Gln Glu Gly Gly Gly Gly Arg Gly 
                325                 330                 335     


Gly Trp Gly Gly Gly Gly Gly Gly Gly Gly Arg Gly Gly Gly Gly Gly 
            340                 345                 350         


Gly Gly Gly Arg Gly Gly Trp Gly Gly Gly Gly Gly Gly Trp Gly Gly 
        355                 360                 365             


Gly Gly Gly Gly Gly Gly Gly Trp Gly Gly Gly Gly Gly Gly Gly Arg 
    370                 375                 380                 


Gly Gly Phe Gln Gly Arg Gly Asp Tyr Gly Gly Arg Gly Gly Tyr Gly 
385                 390                 395                 400 


Gly Arg Gly Gly Tyr Gly Gly Arg Gly Tyr Gly Asp Pro Tyr Gly Gly 
                405                 410                 415     


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Tyr Arg Arg 
            420                 425                 430         


Tyr 
    

<210>  469
<211>  5048
<212>  DNA
<213>  Homo sapiens

<400>  469
acaaagtttg tgcctgcggt gcacctcggt cgggctcgcc gggctcgagg gctggcgggc     60

gccggggcta cgaggcccgg gggggagaga gccggcaggc ggcggcggtg gtggcggggg    120

cgatgcgccg cgcccggccg cgctaggtga gccggcaccg ggagcgcggg ccgcggccat    180

gggcaccctg ggcaaggcga gagaggctcc gcggaaacct tcccatggct gcagagctgc    240

ctctaaagca agactagagg caaagccagc caacagcccc ttcccctccc atcccagctt    300

ggcccacatc acccagttcc gaatgatggt gtctctggga catttagcca aaggagccag    360

cctggacgat ctcattgaca gctgcattca atcttttgat gcagatggaa acctgtgtcg    420

aagtaaccaa ctgttgcaag tcatgctgac catgcaccga attgtcatct cctctgcaga    480

actgctccaa aaagttatca ccctctataa ggatgctttg gcaaagaatt caccaggact    540

ttgcctgaag atctgttatt ttgtaaggta ttggataaca gaattctggg tcatgtttaa    600

aatggacgcc agcttgacag acactatgga ggagtttcag gaactggtga aagctaaggg    660

tgaggagtta cattgccgcc tgattgacac aactcaaatc aatgcccgtg actggtccag    720

gaaacttact caaaggataa aatcaaatac cagcaagaaa cggaaagtct ccctgctctt    780

tgaccatctg gaaccagaag agctatccga gcacctcacc taccttgagt tcaagtcttt    840

ccggaggata tcgttctctg attatcagaa ttaccttgta aatagctgtg tgaaggaaaa    900

ccccaccatg gagcgatcta ttgctctgtg caacggcatc tcccagtggg tacaactgat    960

ggttctcagc cgccccacgc cgcagctccg agcagaagtc ttcatcaagt tcatccaggt   1020

ggctcagaag ctccaccaac tacagaactt caatacactg atggctgtga taggtgggct   1080

gtgtcacagc tcaatctcga ggctcaagga gacaagttcg catgtcccac atgaaatcaa   1140

taaggttctc ggtgagatga ctgagctgct gtcctcctcc agaaactacg acaattaccg   1200

gcgagcctat ggagagtgca ccgacttcaa gatccccatt ctgggtgtgc atctcaagga   1260

cctcatctcc ctgtatgaag ccatgcctga ctatctggag gacgggaaag tgaacgtcca   1320

taagctactg gccctataca atcatatcag tgaattggtc cagctgcaag aggtggcccc   1380

acccttggag gctaacaagg acttggtaca cttgctgacg ttatccctgg atctttacta   1440

cactgaggat gaaatctatg agctttccta tgcccgggaa ccaaggaacc acagagctcc   1500

accactaaca ccttcaaagc caccagtagt agtggactgg gcttctggag tgtctcccaa   1560

acctgatcca aaaaccatta gcaaacacgt ccagaggatg gtggattctg tcttcaagaa   1620

ctatgatcac gaccaggatg gatacatttc tcaggaagaa tttgaaaaga ttgctgcgag   1680

ttttccattt tccttctgtg tgatggacaa agacagggaa ggcctcatca gcagggatga   1740

gatcacagcc tacttcatga gagccagctc aatctattcc aagctgggcc tgggctttcc   1800

tcacaacttc caagagacca cctacctgaa gcccactttt tgtgacaact gtgctggatt   1860

tctctgggga gtgatcaaac aaggatatcg atgtaaagac tgcgggatga actgtcacaa   1920

acaatgcaaa gatctggttg tgtttgagtg taagaagcga gccaagaacc cagtagctcc   1980

cacagagaac aacacttctg tggggccagt gtccaacctt tgctcattgg gagccaaaga   2040

tctgctccat gcacctgagg aaggaccttt tacattccct aatggggagg ctgtggaaca   2100

tggtgaggag agtaaggatc ggaccatcat gctgatggga gtgtcctcac agaagatttc   2160

tcttcggctg aagagggctg ttgcccacaa ggccacccag actgaatcac agccttggat   2220

tggcagtgag ggcccttcag gtccctttgt gctgtcttcc ccaaggaaga cagcccagga   2280

tactctatat gtgcttccca gtcccacctc tccatgtcct agcccagtct tggtcagaaa   2340

gcgggctttt gtcaagtggg agaataaaga ctccctcata aaatcaaagg aggagctccg   2400

tcacctcaga ctgcctacct accaagaact ggaacaggaa ataaatactc tgaaagcaga   2460

taatgatgcc ctaaagatcc aactgaaata tgcacagaag aaaatagaat ccctccagct   2520

tgaaaaaagc aatcatgtct tagctcaaat ggagcagggt gactgttctt agcccagaaa   2580

ctaagtagca caatctgtag atgagtatag tgatctcatt tcctaaactg taatgcacag   2640

acctgaggaa ctttacactg accagcttta aaacagtact ttaaaaggaa aagcctgtta   2700

ctgtttattt acctaaaaga ttcctaatgt gcagcactgt tttctctttc agttagttga   2760

ctcaaagggg gaaaactaaa gaatgcaaaa cttttgctat tcataccact gatgttcatc   2820

aaaagtatgc gatctaaaac atgactatca tttcctgaca atggggcatc tcggtggcct   2880

gcctggctga ttcttcctta aaactaaaat ctctggaaaa tggatttgct tcttaccctg   2940

tgttttctgc aaactgactt actttgttcc agccaaagct tgctaataat agaaaactac   3000

ccatattcca aaagtagatt tcctctgtat cccagcatac tttgtgaacc tggctccttc   3060

ttcactacct cagatctaat caattagtcc atgtaccctc cttcctcact acagtcataa   3120

cacatgagca tatctaccta gaagccaatt tctactgatg tagccacaac tttttagagg   3180

cctattaaac atgacgttat ccaattgcag gtcaacttat agttgtagcc ttacaactta   3240

caggcatcag aaaataagta atcaaattag gtacctggaa acatagctat taccatctca   3300

tattactgtc taattaaaat aaacataacg caaacatgtt tgtccttata tattctacag   3360

tggatagaat taggaattga tggcttaaaa aaaaaagtct atgaagagtc tgtttaactc   3420

ttcatgttcc atctttctct tctgaagtaa actattttga aagttctctt tttgaaatga   3480

atttgtgctt aactgtcttc actattaata ctatttagaa ataagctaat tggatcagtg   3540

gcttaaataa tagctgactg tgtgtacata tgtatataat atgtatatac aatatcaggc   3600

atgcatgtgg cttggaattt tgtttcctcc ataaaatgtg gaagtgaatt aaacaagttt   3660

tagtcattta tacaaagtca caaatataaa gttcagtttg tcacaagatt aaattgctca   3720

caaggtaaaa ttgtattgtt tggcaaaatc acaagtaaca atcctgtgag ttttctatta   3780

tgaaggttaa taataaatgg gctcatttag ttgcctgggc acctattcac aaattcattt   3840

gtcagcctct ttttagttct cttaaaaaaa aaaaaatcat atgatcattt tcctttttgg   3900

gggtacttag cttccatgcc tataaagtct ggtaccagac tgacttgaaa ttcataaaca   3960

agttgtccaa ttgccaagaa tatgttaaca attaaaagtt ccaaactaaa gccaatagca   4020

ccaagtcttc ataagaatac aaagtataca tacagtattg cttacctgga ggattcagat   4080

catttaggaa ttctctttga tgaaagatca gttcccattt gagttcctcc ttgcactgag   4140

ttttagtgat atagaactag cttgtagtta gtgtttcatt acattataaa gaatagtttt   4200

acacacgtat ttaccgtttt ccaaatttaa actcagaaat acccaaagca ggcctgctta   4260

agcccactac ctggcatata aacttatagt aacactttgt tactttcttt ttaataggac   4320

aagcatgagt taggacaaac tctaaaaatt catattcttc actattcttg ttttcctttg   4380

attgatatag accaaagatg gtgtactcta attttttaaa acagtaatgg aacacaattt   4440

ttttcattct tcctcctctc cattcgaagt aaagatcccc agttagtttt tatataaata   4500

atctataggg attcaaaagg tgtcacagtc cacttaatta gtcaaattag caatggctaa   4560

acagtatcaa gtactgcaga atttatcact gaaatggata agaggaaata gtttagtcac   4620

aggtttttac agtccagcaa gggccaaaga ggtatagtat acaagttaat agtatttgtg   4680

ttgagcaaca tggggctagt gggatcacag aaatctggaa aaaaaaaaaa aaggctttgg   4740

cttatcaagc ctagtgtaaa tttctgcatc tcacacgact ttagtttggc caggtattta   4800

tctgccaaaa caaggacaaa tcttgttgta ttaacagcag ggtcacttct cattttcttt   4860

gctgacttac ctttttactg accgttgtga atttctgtct caaaatgtat aatatagaaa   4920

tgcaagaaaa aaacaaatgt acagattgta aagttttttg atacctaatg taagttttct   4980

ttgtgtaata tttatatgat aaaagacatt aggatcccta caacaaaaaa aaaaaaaaaa   5040

aaaaaaaa                                                            5048


<210>  470
<211>  797
<212>  PRT
<213>  Homo sapiens

<400>  470


Met Gly Thr Leu Gly Lys Ala Arg Glu Ala Pro Arg Lys Pro Ser His 
1               5                   10                  15      


Gly Cys Arg Ala Ala Ser Lys Ala Arg Leu Glu Ala Lys Pro Ala Asn 
            20                  25                  30          


Ser Pro Phe Pro Ser His Pro Ser Leu Ala His Ile Thr Gln Phe Arg 
        35                  40                  45              


Met Met Val Ser Leu Gly His Leu Ala Lys Gly Ala Ser Leu Asp Asp 
    50                  55                  60                  


Leu Ile Asp Ser Cys Ile Gln Ser Phe Asp Ala Asp Gly Asn Leu Cys 
65                  70                  75                  80  


Arg Ser Asn Gln Leu Leu Gln Val Met Leu Thr Met His Arg Ile Val 
                85                  90                  95      


Ile Ser Ser Ala Glu Leu Leu Gln Lys Val Ile Thr Leu Tyr Lys Asp 
            100                 105                 110         


Ala Leu Ala Lys Asn Ser Pro Gly Leu Cys Leu Lys Ile Cys Tyr Phe 
        115                 120                 125             


Val Arg Tyr Trp Ile Thr Glu Phe Trp Val Met Phe Lys Met Asp Ala 
    130                 135                 140                 


Ser Leu Thr Asp Thr Met Glu Glu Phe Gln Glu Leu Val Lys Ala Lys 
145                 150                 155                 160 


Gly Glu Glu Leu His Cys Arg Leu Ile Asp Thr Thr Gln Ile Asn Ala 
                165                 170                 175     


Arg Asp Trp Ser Arg Lys Leu Thr Gln Arg Ile Lys Ser Asn Thr Ser 
            180                 185                 190         


Lys Lys Arg Lys Val Ser Leu Leu Phe Asp His Leu Glu Pro Glu Glu 
        195                 200                 205             


Leu Ser Glu His Leu Thr Tyr Leu Glu Phe Lys Ser Phe Arg Arg Ile 
    210                 215                 220                 


Ser Phe Ser Asp Tyr Gln Asn Tyr Leu Val Asn Ser Cys Val Lys Glu 
225                 230                 235                 240 


Asn Pro Thr Met Glu Arg Ser Ile Ala Leu Cys Asn Gly Ile Ser Gln 
                245                 250                 255     


Trp Val Gln Leu Met Val Leu Ser Arg Pro Thr Pro Gln Leu Arg Ala 
            260                 265                 270         


Glu Val Phe Ile Lys Phe Ile Gln Val Ala Gln Lys Leu His Gln Leu 
        275                 280                 285             


Gln Asn Phe Asn Thr Leu Met Ala Val Ile Gly Gly Leu Cys His Ser 
    290                 295                 300                 


Ser Ile Ser Arg Leu Lys Glu Thr Ser Ser His Val Pro His Glu Ile 
305                 310                 315                 320 


Asn Lys Val Leu Gly Glu Met Thr Glu Leu Leu Ser Ser Ser Arg Asn 
                325                 330                 335     


Tyr Asp Asn Tyr Arg Arg Ala Tyr Gly Glu Cys Thr Asp Phe Lys Ile 
            340                 345                 350         


Pro Ile Leu Gly Val His Leu Lys Asp Leu Ile Ser Leu Tyr Glu Ala 
        355                 360                 365             


Met Pro Asp Tyr Leu Glu Asp Gly Lys Val Asn Val His Lys Leu Leu 
    370                 375                 380                 


Ala Leu Tyr Asn His Ile Ser Glu Leu Val Gln Leu Gln Glu Val Ala 
385                 390                 395                 400 


Pro Pro Leu Glu Ala Asn Lys Asp Leu Val His Leu Leu Thr Leu Ser 
                405                 410                 415     


Leu Asp Leu Tyr Tyr Thr Glu Asp Glu Ile Tyr Glu Leu Ser Tyr Ala 
            420                 425                 430         


Arg Glu Pro Arg Asn His Arg Ala Pro Pro Leu Thr Pro Ser Lys Pro 
        435                 440                 445             


Pro Val Val Val Asp Trp Ala Ser Gly Val Ser Pro Lys Pro Asp Pro 
    450                 455                 460                 


Lys Thr Ile Ser Lys His Val Gln Arg Met Val Asp Ser Val Phe Lys 
465                 470                 475                 480 


Asn Tyr Asp His Asp Gln Asp Gly Tyr Ile Ser Gln Glu Glu Phe Glu 
                485                 490                 495     


Lys Ile Ala Ala Ser Phe Pro Phe Ser Phe Cys Val Met Asp Lys Asp 
            500                 505                 510         


Arg Glu Gly Leu Ile Ser Arg Asp Glu Ile Thr Ala Tyr Phe Met Arg 
        515                 520                 525             


Ala Ser Ser Ile Tyr Ser Lys Leu Gly Leu Gly Phe Pro His Asn Phe 
    530                 535                 540                 


Gln Glu Thr Thr Tyr Leu Lys Pro Thr Phe Cys Asp Asn Cys Ala Gly 
545                 550                 555                 560 


Phe Leu Trp Gly Val Ile Lys Gln Gly Tyr Arg Cys Lys Asp Cys Gly 
                565                 570                 575     


Met Asn Cys His Lys Gln Cys Lys Asp Leu Val Val Phe Glu Cys Lys 
            580                 585                 590         


Lys Arg Ala Lys Asn Pro Val Ala Pro Thr Glu Asn Asn Thr Ser Val 
        595                 600                 605             


Gly Pro Val Ser Asn Leu Cys Ser Leu Gly Ala Lys Asp Leu Leu His 
    610                 615                 620                 


Ala Pro Glu Glu Gly Pro Phe Thr Phe Pro Asn Gly Glu Ala Val Glu 
625                 630                 635                 640 


His Gly Glu Glu Ser Lys Asp Arg Thr Ile Met Leu Met Gly Val Ser 
                645                 650                 655     


Ser Gln Lys Ile Ser Leu Arg Leu Lys Arg Ala Val Ala His Lys Ala 
            660                 665                 670         


Thr Gln Thr Glu Ser Gln Pro Trp Ile Gly Ser Glu Gly Pro Ser Gly 
        675                 680                 685             


Pro Phe Val Leu Ser Ser Pro Arg Lys Thr Ala Gln Asp Thr Leu Tyr 
    690                 695                 700                 


Val Leu Pro Ser Pro Thr Ser Pro Cys Pro Ser Pro Val Leu Val Arg 
705                 710                 715                 720 


Lys Arg Ala Phe Val Lys Trp Glu Asn Lys Asp Ser Leu Ile Lys Ser 
                725                 730                 735     


Lys Glu Glu Leu Arg His Leu Arg Leu Pro Thr Tyr Gln Glu Leu Glu 
            740                 745                 750         


Gln Glu Ile Asn Thr Leu Lys Ala Asp Asn Asp Ala Leu Lys Ile Gln 
        755                 760                 765             


Leu Lys Tyr Ala Gln Lys Lys Ile Glu Ser Leu Gln Leu Glu Lys Ser 
    770                 775                 780                 


Asn His Val Leu Ala Gln Met Glu Gln Gly Asp Cys Ser 
785                 790                 795         

<210>  471
<211>  2309
<212>  DNA
<213>  Homo sapiens

<400>  471
gcgggggcgg gccggggcgg ggccaggccg gctagagggg cgggtctagc ggcggccccc     60

ggcgaagttc actgcgcttg cgctgacaga cgcaagatgg cggacagtgc ggaactaaag    120

caaatggtta tgagccttag agtttctgaa ctccaagtac tgttgggcta cgccgggaga    180

aacaagcacg gacgcaaaca cgaacttctc acaaaagccc tgcatttgct aaaggctggc    240

tgtagtcctg ctgtgcaaat gaaaattaag gaactctata ggcggcggtt cccacagaaa    300

atcatgacgc ctgcagactt gtccatcccc aacgtacatt caagtcctat gccagcaact    360

ttgtctccat ctaccattcc acaactcact tacgatggtc accctgcatc atcgccatta    420

ctccctgttt ctcttctggg acctaaacat gaactggaac tcccacatct tacatcagct    480

cttcacccag tccatccgga tataaaactt caaaaattac cattttatga tttactggat    540

gaactgataa aacccaccag tctagcatca gacaacagtc agcgctttcg agaaacctgt    600

tttgcatttg ccttgacacc acaacaagtg cagcaaatca gtagttccat ggatatttct    660

gggaccaaat gtgacttcac agtacaggtc cagttaaggt tttgtttatc agaaaccagt    720

tgtccacaag aagatcactt cccacccaat ctttgtgtga aagtgaatac aaaaccttgc    780

agccttccag gttaccttcc acctacaaaa aatggcgtgg aaccaaagcg acccagccga    840

ccaattaata tcacctcact tgtccgactg tccacaacag taccaaacac gattgttgtt    900

tcttggactg cagaaattgg aagaaactat tccatggcag tatatcttgt aaaacagttg    960

tcctcaacag ttcttcttca gaggttacga gcaaagggaa taaggaatcc ggatcattct   1020

agagctttaa ttaaagagaa gttgactgcg gatccagaca gtgaaatagc tacaaccagc   1080

ctaagggttt ctctactatg tccacttggt aaaatgcggc tgacaattcc gtgtcgggcc   1140

cttacatgtt ctcatctaca atgttttgac gcaactcttt acattcagat gaatgagaaa   1200

aaaccaacct gggtttgtcc tgtctgtgat aagaaggctc catatgaaca ccttattatt   1260

gatggcttgt ttatggaaat cctaaagtac tgtacagact gtgatgaaat acaatttaag   1320

gaggatggca cttgggcacc gatgagatca aaaaaggaag tacaggaagt ttctgcctct   1380

tacaatggag tcgatggatg cttgagctcc acattggagc atcaggtagc gtctcaccac   1440

cagtcctcaa ataaaaacaa gaaagtagaa gtgattgacc taaccataga cagttcatct   1500

gatgaagagg aagaagagcc atctgccaag aggacctgtc cttccctatc tcccacatca   1560

ccactaaata ataaaggcat tttaagtctt ccacatcaag catctccagt atcccgcacc   1620

ccaagccttc ctgctgtaga cacaagctac attaatacct ccctcatcca agactatagg   1680

catcctttcc acatgacacc catgccttac gacttacaag gattagattt ctttcctttc   1740

ttatcaggag acaatcagca ttacaacacc tccttgcttg ccgctgcagc agcagcagtt   1800

tcagatgatc aagacctcct acactcgtct cggtttttcc cgtatacctc ctcacagatg   1860

tttcttgatc agttaagtgc aggaggcagt acttctctgc caaccaccaa tggaagcagt   1920

agtggcagta acagcagcct ggtttcttcc aacagcctaa gggaaagcca tagccacacc   1980

gtcacaaaca ggagcagcac ggacacggca tccatctttg gcatcatacc agacattatt   2040

tcattggact gattcccagg ccctgctgct cccatcccca ccccagatcg aatgaacttg   2100

gcagaaagaa gagaactttg tgctctgttt taccttactc tgtttagaaa agtatacaag   2160

cgtgtttttt ttcctttttt tagggaaaaa attaaaagaa atgtacagag aacaaaacta   2220

tattttcagt tttacttttg tatataaatc taagactgcc tgtgtgataa aacacttgtt   2280

taaaaaaaaa aaaaaaaaaa aaaaaaaaa                                     2309


<210>  472
<211>  651
<212>  PRT
<213>  Homo sapiens

<400>  472


Met Ala Asp Ser Ala Glu Leu Lys Gln Met Val Met Ser Leu Arg Val 
1               5                   10                  15      


Ser Glu Leu Gln Val Leu Leu Gly Tyr Ala Gly Arg Asn Lys His Gly 
            20                  25                  30          


Arg Lys His Glu Leu Leu Thr Lys Ala Leu His Leu Leu Lys Ala Gly 
        35                  40                  45              


Cys Ser Pro Ala Val Gln Met Lys Ile Lys Glu Leu Tyr Arg Arg Arg 
    50                  55                  60                  


Phe Pro Gln Lys Ile Met Thr Pro Ala Asp Leu Ser Ile Pro Asn Val 
65                  70                  75                  80  


His Ser Ser Pro Met Pro Ala Thr Leu Ser Pro Ser Thr Ile Pro Gln 
                85                  90                  95      


Leu Thr Tyr Asp Gly His Pro Ala Ser Ser Pro Leu Leu Pro Val Ser 
            100                 105                 110         


Leu Leu Gly Pro Lys His Glu Leu Glu Leu Pro His Leu Thr Ser Ala 
        115                 120                 125             


Leu His Pro Val His Pro Asp Ile Lys Leu Gln Lys Leu Pro Phe Tyr 
    130                 135                 140                 


Asp Leu Leu Asp Glu Leu Ile Lys Pro Thr Ser Leu Ala Ser Asp Asn 
145                 150                 155                 160 


Ser Gln Arg Phe Arg Glu Thr Cys Phe Ala Phe Ala Leu Thr Pro Gln 
                165                 170                 175     


Gln Val Gln Gln Ile Ser Ser Ser Met Asp Ile Ser Gly Thr Lys Cys 
            180                 185                 190         


Asp Phe Thr Val Gln Val Gln Leu Arg Phe Cys Leu Ser Glu Thr Ser 
        195                 200                 205             


Cys Pro Gln Glu Asp His Phe Pro Pro Asn Leu Cys Val Lys Val Asn 
    210                 215                 220                 


Thr Lys Pro Cys Ser Leu Pro Gly Tyr Leu Pro Pro Thr Lys Asn Gly 
225                 230                 235                 240 


Val Glu Pro Lys Arg Pro Ser Arg Pro Ile Asn Ile Thr Ser Leu Val 
                245                 250                 255     


Arg Leu Ser Thr Thr Val Pro Asn Thr Ile Val Val Ser Trp Thr Ala 
            260                 265                 270         


Glu Ile Gly Arg Asn Tyr Ser Met Ala Val Tyr Leu Val Lys Gln Leu 
        275                 280                 285             


Ser Ser Thr Val Leu Leu Gln Arg Leu Arg Ala Lys Gly Ile Arg Asn 
    290                 295                 300                 


Pro Asp His Ser Arg Ala Leu Ile Lys Glu Lys Leu Thr Ala Asp Pro 
305                 310                 315                 320 


Asp Ser Glu Ile Ala Thr Thr Ser Leu Arg Val Ser Leu Leu Cys Pro 
                325                 330                 335     


Leu Gly Lys Met Arg Leu Thr Ile Pro Cys Arg Ala Leu Thr Cys Ser 
            340                 345                 350         


His Leu Gln Cys Phe Asp Ala Thr Leu Tyr Ile Gln Met Asn Glu Lys 
        355                 360                 365             


Lys Pro Thr Trp Val Cys Pro Val Cys Asp Lys Lys Ala Pro Tyr Glu 
    370                 375                 380                 


His Leu Ile Ile Asp Gly Leu Phe Met Glu Ile Leu Lys Tyr Cys Thr 
385                 390                 395                 400 


Asp Cys Asp Glu Ile Gln Phe Lys Glu Asp Gly Thr Trp Ala Pro Met 
                405                 410                 415     


Arg Ser Lys Lys Glu Val Gln Glu Val Ser Ala Ser Tyr Asn Gly Val 
            420                 425                 430         


Asp Gly Cys Leu Ser Ser Thr Leu Glu His Gln Val Ala Ser His His 
        435                 440                 445             


Gln Ser Ser Asn Lys Asn Lys Lys Val Glu Val Ile Asp Leu Thr Ile 
    450                 455                 460                 


Asp Ser Ser Ser Asp Glu Glu Glu Glu Glu Pro Ser Ala Lys Arg Thr 
465                 470                 475                 480 


Cys Pro Ser Leu Ser Pro Thr Ser Pro Leu Asn Asn Lys Gly Ile Leu 
                485                 490                 495     


Ser Leu Pro His Gln Ala Ser Pro Val Ser Arg Thr Pro Ser Leu Pro 
            500                 505                 510         


Ala Val Asp Thr Ser Tyr Ile Asn Thr Ser Leu Ile Gln Asp Tyr Arg 
        515                 520                 525             


His Pro Phe His Met Thr Pro Met Pro Tyr Asp Leu Gln Gly Leu Asp 
    530                 535                 540                 


Phe Phe Pro Phe Leu Ser Gly Asp Asn Gln His Tyr Asn Thr Ser Leu 
545                 550                 555                 560 


Leu Ala Ala Ala Ala Ala Ala Val Ser Asp Asp Gln Asp Leu Leu His 
                565                 570                 575     


Ser Ser Arg Phe Phe Pro Tyr Thr Ser Ser Gln Met Phe Leu Asp Gln 
            580                 585                 590         


Leu Ser Ala Gly Gly Ser Thr Ser Leu Pro Thr Thr Asn Gly Ser Ser 
        595                 600                 605             


Ser Gly Ser Asn Ser Ser Leu Val Ser Ser Asn Ser Leu Arg Glu Ser 
    610                 615                 620                 


His Ser His Thr Val Thr Asn Arg Ser Ser Thr Asp Thr Ala Ser Ile 
625                 630                 635                 640 


Phe Gly Ile Ile Pro Asp Ile Ile Ser Leu Asp 
                645                 650     

<210>  473
<211>  7080
<212>  DNA
<213>  Homo sapiens

<400>  473
gagctagcgc tcaagcagag cccagcgcgg tgctatcgga cagagcctgg cgagcgcaag     60

cggcgcgggg agccagcggg gctgagcgcg gccagggtct gaacccagat ttcccagact    120

agctaccact ccgcttgccc acgccccggg agctcgcggc gcctggcggt cagcgaccag    180

acgtccgggg ccgctgcgct cctggcccgc gaggcgtgac actgtctcgg ctacagaccc    240

agagggagca cactgccagg atgggagctg ctgggaggca ggacttcctc ttcaaggcca    300

tgctgaccat cagctggctc actctgacct gcttccctgg ggccacatcc acagtggctg    360

ctgggtgccc tgaccagagc cctgagttgc aaccctggaa ccctggccat gaccaagacc    420

accatgtgca tatcggccag ggcaagacac tgctgctcac ctcttctgcc acggtctatt    480

ccatccacat ctcagaggga ggcaagctgg tcattaaaga ccacgacgag ccgattgttt    540

tgcgaacccg gcacatcctg attgacaacg gaggagagct gcatgctggg agtgccctct    600

gccctttcca gggcaatttc accatcattt tgtatggaag ggctgatgaa ggtattcagc    660

cggatcctta ctatggtctg aagtacattg gggttggtaa aggaggcgct cttgagttgc    720

atggacagaa aaagctctcc tggacatttc tgaacaagac ccttcaccca ggtggcatgg    780

cagaaggagg ctattttttt gaaaggagct ggggccaccg tggagttatt gttcatgtca    840

tcgaccccaa atcaggcaca gtcatccatt ctgaccggtt tgacacctat agatccaaga    900

aagagagtga acgtctggtc cagtatttga acgcggtgcc cgatggcagg atcctttctg    960

ttgcagtgaa tgatgaaggt tctcgaaatc tggatgacat ggccaggaag gcgatgacca   1020

aattgggaag caaacacttc ctgcaccttg gatttagaca cccttggagt tttctaactg   1080

tgaaaggaaa tccatcatct tcagtggaag accatattga atatcatgga catcgaggct   1140

ctgctgctgc ccgggtattc aaattgttcc agacagagca tggcgaatat ttcaatgttt   1200

ctttgtccag tgagtgggtt caagacgtgg agtggacgga gtggttcgat catgataaag   1260

tatctcagac taaaggtggg gagaaaattt cagacctctg gaaagctcac ccaggaaaaa   1320

tatgcaatcg tcccattgat atacaggcca ctacaatgga tggagttaac ctcagcaccg   1380

aggttgtcta caaaaaaggc caggattata ggtttgcttg ctacgaccgg ggcagagcct   1440

gccggagcta ccgtgtacgg ttcctctgtg ggaagcctgt gaggcccaaa ctcacagtca   1500

ccattgacac caatgtgaac agcaccattc tgaacttgga ggataatgta cagtcatgga   1560

aacctggaga taccctggtc attgccagta ctgattactc catgtaccag gcagaagagt   1620

tccaggtgct tccctgcaga tcctgcgccc ccaaccaggt caaagtggca gggaaaccaa   1680

tgtacctgca catcggggag gagatagacg gcgtggacat gcgggcggag gttgggcttc   1740

tgagccggaa catcatagtg atgggggaga tggaggacaa atgctacccc tacagaaacc   1800

acatctgcaa tttctttgac ttcgatacct ttgggggcca catcaagttt gctctgggat   1860

ttaaggcagc acacttggag ggcacggagc tgaagcatat gggacagcag ctggtgggtc   1920

agtacccgat tcacttccac ctggccggtg atgtagacga aaggggaggt tatgacccac   1980

ccacatacat cagggacctc tccatccatc atacattctc tcgctgcgtc acagtccatg   2040

gctccaatgg cttgttgatc aaggacgttg tgggctataa ctctttgggc cactgcttct   2100

tcacggaaga tgggccggag gaacgcaaca cttttgacca ctgtcttggc ctccttgtca   2160

agtctggaac cctcctcccc tcggaccgtg acagcaagat gtgcaagatg atcacagagg   2220

actcctaccc ggggtacatc cccaagccca ggcaagactg caatgctgtg tccaccttct   2280

ggatggccaa tcccaacaac aacctcatca actgtgccgc tgcaggatct gaggaaactg   2340

gattttggtt tatttttcac cacgtaccaa cgggcccctc cgtgggaatg tactccccag   2400

gttattcaga gcacattcca ctgggaaaat tctataacaa ccgagcacat tccaactacc   2460

gggctggcat gatcatagac aacggagtca aaaccaccga ggcctctgcc aaggacaagc   2520

ggccgttcct ctcaatcatc tctgccagat acagccctca ccaggacgcc gacccgctga   2580

agccccggga gccggccatc atcagacact tcattgccta caagaaccag gaccacgggg   2640

cctggctgcg cggcggggat gtgtggctgg acagctgccg gtttgctgac aatggcattg   2700

gcctgaccct ggccagtggt ggaaccttcc cgtatgacga cggctccaag caagagataa   2760

agaacagctt gtttgttggc gagagtggca acgtggggac ggaaatgatg gacaatagga   2820

tctggggccc tggcggcttg gaccatagcg gaaggaccct ccctataggc cagaattttc   2880

caattagagg aattcagtta tatgatggcc ccatcaacat ccaaaactgc actttccgaa   2940

agtttgtggc cctggagggc cggcacacca gcgccctggc cttccgcctg aataatgcct   3000

ggcagagctg cccccataac aacgtgaccg gcattgcctt tgaggacgtt ccgattactt   3060

ccagagtgtt cttcggagag cctgggccct ggttcaacca gctggacatg gatggggata   3120

agacatctgt gttccatgac gtcgacggct ccgtgtccga gtaccctggc tcctacctca   3180

cgaagaatga caactggctg gtccggcacc cagactgcat caatgttccc gactggagag   3240

gggccatttg cagtgggtgc tatgcacaga tgtacattca agcctacaag accagtaacc   3300

tgcgaatgaa gatcatcaag aatgacttcc ccagccaccc tctttacctg gagggggcgc   3360

tcaccaggag cacccattac cagcaatacc aaccggttgt caccctgcag aagggctaca   3420

ccatccactg ggaccagacg gcccccgccg aactcgccat ctggctcatc aacttcaaca   3480

agggcgactg gatccgagtg gggctctgct acccgcgagg caccacattc tccatcctct   3540

cggatgttca caatcgcctg ctgaagcaaa cgtccaagac gggcgtcttc gtgaggacct   3600

tgcagatgga caaagtggag cagagctacc ctggcaggag ccactactac tgggacgagg   3660

actcagggct gttgttcctg aagctgaaag ctcagaacga gagagagaag tttgctttct   3720

gctccatgaa aggctgtgag aggataaaga ttaaagctct gattccaaag aacgcaggcg   3780

tcagtgactg cacagccaca gcttacccca agttcaccga gagggctgtc gtagacgtgc   3840

cgatgcccaa gaagctcttt ggttctcagc tgaaaacaaa ggaccatttc ttggaggtga   3900

agatggagag ttccaagcag cacttcttcc acctctggaa cgacttcgct tacattgaag   3960

tggatgggaa gaagtacccc agttcggagg atggcatcca ggtggtggtg attgacggga   4020

accaagggcg cgtggtgagc cacacgagct tcaggaactc cattctgcaa ggcataccat   4080

ggcagctttt caactatgtg gcgaccatcc ctgacaattc catagtgctt atggcatcaa   4140

agggaagata cgtctccaga ggcccatgga ccagagtgct ggaaaagctt ggggcagaca   4200

ggggtctcaa gttgaaagag caaatggcat tcgttggctt caaaggcagc ttccggccca   4260

tctgggtgac actggacact gaggatcaca aagccaaaat cttccaagtt gtgcccatcc   4320

ctgtggtgaa gaagaagaag ttgtgaggac agctgccgcc cggtgccacc tcgtggtaga   4380

ctatgacggt gactcttggc agcagaccag tgggggatgg ctgggtcccc cagcccctgc   4440

cagcagctgc ctgggaaggc cgtgtttcag ccctgatggg ccaagggaag gctatcagag   4500

accctggtgc tgccacctgc ccctactcaa gtgtctacct ggagcccctg gggcggtgct   4560

ggccaatgct ggaaacattc actttcctgc agcctcttgg gtgcttctct cctatctgtg   4620

cctcttcagt gggggtttgg ggaccatatc aggagacctg ggttgtgctg acagcaaaga   4680

tccactttgg caggagccct gacccagcta ggaggtagtc tggagggctg gtcattcaca   4740

gatccccatg gtcttcagca gacaagtgag ggtggtaaat gtaggagaaa gagccttggc   4800

cttaaggaaa tctttactcc tgtaagcaag agccaacctc acaggattag gagctggggt   4860

agaactggct atccttgggg aagaggcaag ccctgcctct ggccgtgtcc acctttcagg   4920

agactttgag tggcaggttt ggacttggac tagatgactc tcaaaggccc ttttagttct   4980

gagattccag aaatctgctg catttcacat ggtacctgga acccaacagt tcatggatat   5040

ccactgatat ccatgatgct gggtgcccca gcgcacacgg gatggagagg tgagaactaa   5100

tgcctagctt gaggggtctg cagtccagta gggcaggcag tcaggtccat gtgcactgca   5160

atgccaggtg gagaaatcac agagaggtaa aatggaggcc agtgccattt cagaggggag   5220

gctcaggaag gcttcttgct tacaggaatg aaggctgggg gcattttgct ggggggagat   5280

gaggcagcct ctggaatggc tcagggattc agccctccct gccgctgcct gctgaagctg   5340

gtgactacgg ggtcgccctt tgctcacgtc tctctggccc actcatgatg gagaagtgtg   5400

gtcagagggg agcaatgggc tttgctgctt atgagcacag aggaattcag tccccaggca   5460

gccctgcctc tgactccaag agggtgaagt ccacagaagt gagctcctgc cttagggcct   5520

catttgctct tcatccaggg aactgagcac agggggcctc caggagaccc tagatgtgct   5580

cgtactccct cggcctggga tttcagagct ggaaatatag aaaatatcta gcccaaagcc   5640

ttcattttaa cagatgggga aagtgagccc ccaagatggg aaagaaccac acagctaagg   5700

gagggcctgg ggagccccac cctagccctt gctgccacac cacattgcct caacaaccgg   5760

ccccagagtg cccaggcact cctgaggtag cttctggaaa tggggacaag tcccctcgaa   5820

ggaaaggaaa tgactagagt agaatgacag ctagcagatc tcttccctcc tgctcccagc   5880

gcacacaaac ccgccctccc cttggtgttg gcggtccctg tggccttcac tttgttcact   5940

acctgtcagc ccagcctggg tgcacagtag ctgcaactcc ccattggtgc tacctggctc   6000

tcctgtctct gcagctctac aggtgaggcc cagcagaggg agtagggctc gccatgtttc   6060

tggtgagcca atttggctga tcttgggtgt ctgaacagct attgggtcca ccccagtccc   6120

tttcagctgc tgcttaatgc cctgctctct ccctggccca ccttatagag agcccaaaga   6180

gctcctgtaa gagggagaac tctatctgtg gtttataatc ttgcacgagg caccagagtc   6240

tccctgggtc ttgtgatgaa ctacatttat cccctttcct gccccaacca caaactcttt   6300

ccttcaaaga gggcctgcct ggctccctcc acccaactgc acccatgaga ctcggtccaa   6360

gagtccattc cccaggtggg agccaactgt cagggaggtc tttcccacca aacatctttc   6420

agctgctggg aggtgaccat agggctctgc ttttaaagat atggctgctt caaaggccag   6480

agtcacagga aggacttctt ccagggagat tagtggtgat ggagaggaga gttaaaatga   6540

cctcatgtcc ttcttgtcca cggttttgtt gagttttcac tcttctaatg caagggtctc   6600

acactgtgaa ccacttagga tgtgatcact ttcaggtggc caggaatgtt gaatgtcttt   6660

ggctcagttc atttaaaaaa gatatctatt tgaaagttct cagagttgta catatgtttc   6720

acagtacagg atctgtacat aaaagtttct ttcctaaacc attcaccaag agccaatatc   6780

taggcatttt cttggtagca caaattttct tattgcttag aaaattgtcc tccttgttat   6840

ttctgtttgt aagacttaag tgagttaggt ctttaaggaa agcaacgctc ctctgaaatg   6900

cttgtctttt ttctgttgcc gaaatagctg gtcctttttc gggagttaga tgtatagagt   6960

gtttgtatgt aaacatttct tgtaggcatc accatgaaca aagatatatt ttctatttat   7020

ttattatatg tgcacttcaa gaagtcactg tcagagaaat aaagaattgt cttaaatgtc   7080


<210>  474
<211>  1361
<212>  PRT
<213>  Homo sapiens

<400>  474


Met Gly Ala Ala Gly Arg Gln Asp Phe Leu Phe Lys Ala Met Leu Thr 
1               5                   10                  15      


Ile Ser Trp Leu Thr Leu Thr Cys Phe Pro Gly Ala Thr Ser Thr Val 
            20                  25                  30          


Ala Ala Gly Cys Pro Asp Gln Ser Pro Glu Leu Gln Pro Trp Asn Pro 
        35                  40                  45              


Gly His Asp Gln Asp His His Val His Ile Gly Gln Gly Lys Thr Leu 
    50                  55                  60                  


Leu Leu Thr Ser Ser Ala Thr Val Tyr Ser Ile His Ile Ser Glu Gly 
65                  70                  75                  80  


Gly Lys Leu Val Ile Lys Asp His Asp Glu Pro Ile Val Leu Arg Thr 
                85                  90                  95      


Arg His Ile Leu Ile Asp Asn Gly Gly Glu Leu His Ala Gly Ser Ala 
            100                 105                 110         


Leu Cys Pro Phe Gln Gly Asn Phe Thr Ile Ile Leu Tyr Gly Arg Ala 
        115                 120                 125             


Asp Glu Gly Ile Gln Pro Asp Pro Tyr Tyr Gly Leu Lys Tyr Ile Gly 
    130                 135                 140                 


Val Gly Lys Gly Gly Ala Leu Glu Leu His Gly Gln Lys Lys Leu Ser 
145                 150                 155                 160 


Trp Thr Phe Leu Asn Lys Thr Leu His Pro Gly Gly Met Ala Glu Gly 
                165                 170                 175     


Gly Tyr Phe Phe Glu Arg Ser Trp Gly His Arg Gly Val Ile Val His 
            180                 185                 190         


Val Ile Asp Pro Lys Ser Gly Thr Val Ile His Ser Asp Arg Phe Asp 
        195                 200                 205             


Thr Tyr Arg Ser Lys Lys Glu Ser Glu Arg Leu Val Gln Tyr Leu Asn 
    210                 215                 220                 


Ala Val Pro Asp Gly Arg Ile Leu Ser Val Ala Val Asn Asp Glu Gly 
225                 230                 235                 240 


Ser Arg Asn Leu Asp Asp Met Ala Arg Lys Ala Met Thr Lys Leu Gly 
                245                 250                 255     


Ser Lys His Phe Leu His Leu Gly Phe Arg His Pro Trp Ser Phe Leu 
            260                 265                 270         


Thr Val Lys Gly Asn Pro Ser Ser Ser Val Glu Asp His Ile Glu Tyr 
        275                 280                 285             


His Gly His Arg Gly Ser Ala Ala Ala Arg Val Phe Lys Leu Phe Gln 
    290                 295                 300                 


Thr Glu His Gly Glu Tyr Phe Asn Val Ser Leu Ser Ser Glu Trp Val 
305                 310                 315                 320 


Gln Asp Val Glu Trp Thr Glu Trp Phe Asp His Asp Lys Val Ser Gln 
                325                 330                 335     


Thr Lys Gly Gly Glu Lys Ile Ser Asp Leu Trp Lys Ala His Pro Gly 
            340                 345                 350         


Lys Ile Cys Asn Arg Pro Ile Asp Ile Gln Ala Thr Thr Met Asp Gly 
        355                 360                 365             


Val Asn Leu Ser Thr Glu Val Val Tyr Lys Lys Gly Gln Asp Tyr Arg 
    370                 375                 380                 


Phe Ala Cys Tyr Asp Arg Gly Arg Ala Cys Arg Ser Tyr Arg Val Arg 
385                 390                 395                 400 


Phe Leu Cys Gly Lys Pro Val Arg Pro Lys Leu Thr Val Thr Ile Asp 
                405                 410                 415     


Thr Asn Val Asn Ser Thr Ile Leu Asn Leu Glu Asp Asn Val Gln Ser 
            420                 425                 430         


Trp Lys Pro Gly Asp Thr Leu Val Ile Ala Ser Thr Asp Tyr Ser Met 
        435                 440                 445             


Tyr Gln Ala Glu Glu Phe Gln Val Leu Pro Cys Arg Ser Cys Ala Pro 
    450                 455                 460                 


Asn Gln Val Lys Val Ala Gly Lys Pro Met Tyr Leu His Ile Gly Glu 
465                 470                 475                 480 


Glu Ile Asp Gly Val Asp Met Arg Ala Glu Val Gly Leu Leu Ser Arg 
                485                 490                 495     


Asn Ile Ile Val Met Gly Glu Met Glu Asp Lys Cys Tyr Pro Tyr Arg 
            500                 505                 510         


Asn His Ile Cys Asn Phe Phe Asp Phe Asp Thr Phe Gly Gly His Ile 
        515                 520                 525             


Lys Phe Ala Leu Gly Phe Lys Ala Ala His Leu Glu Gly Thr Glu Leu 
    530                 535                 540                 


Lys His Met Gly Gln Gln Leu Val Gly Gln Tyr Pro Ile His Phe His 
545                 550                 555                 560 


Leu Ala Gly Asp Val Asp Glu Arg Gly Gly Tyr Asp Pro Pro Thr Tyr 
                565                 570                 575     


Ile Arg Asp Leu Ser Ile His His Thr Phe Ser Arg Cys Val Thr Val 
            580                 585                 590         


His Gly Ser Asn Gly Leu Leu Ile Lys Asp Val Val Gly Tyr Asn Ser 
        595                 600                 605             


Leu Gly His Cys Phe Phe Thr Glu Asp Gly Pro Glu Glu Arg Asn Thr 
    610                 615                 620                 


Phe Asp His Cys Leu Gly Leu Leu Val Lys Ser Gly Thr Leu Leu Pro 
625                 630                 635                 640 


Ser Asp Arg Asp Ser Lys Met Cys Lys Met Ile Thr Glu Asp Ser Tyr 
                645                 650                 655     


Pro Gly Tyr Ile Pro Lys Pro Arg Gln Asp Cys Asn Ala Val Ser Thr 
            660                 665                 670         


Phe Trp Met Ala Asn Pro Asn Asn Asn Leu Ile Asn Cys Ala Ala Ala 
        675                 680                 685             


Gly Ser Glu Glu Thr Gly Phe Trp Phe Ile Phe His His Val Pro Thr 
    690                 695                 700                 


Gly Pro Ser Val Gly Met Tyr Ser Pro Gly Tyr Ser Glu His Ile Pro 
705                 710                 715                 720 


Leu Gly Lys Phe Tyr Asn Asn Arg Ala His Ser Asn Tyr Arg Ala Gly 
                725                 730                 735     


Met Ile Ile Asp Asn Gly Val Lys Thr Thr Glu Ala Ser Ala Lys Asp 
            740                 745                 750         


Lys Arg Pro Phe Leu Ser Ile Ile Ser Ala Arg Tyr Ser Pro His Gln 
        755                 760                 765             


Asp Ala Asp Pro Leu Lys Pro Arg Glu Pro Ala Ile Ile Arg His Phe 
    770                 775                 780                 


Ile Ala Tyr Lys Asn Gln Asp His Gly Ala Trp Leu Arg Gly Gly Asp 
785                 790                 795                 800 


Val Trp Leu Asp Ser Cys Arg Phe Ala Asp Asn Gly Ile Gly Leu Thr 
                805                 810                 815     


Leu Ala Ser Gly Gly Thr Phe Pro Tyr Asp Asp Gly Ser Lys Gln Glu 
            820                 825                 830         


Ile Lys Asn Ser Leu Phe Val Gly Glu Ser Gly Asn Val Gly Thr Glu 
        835                 840                 845             


Met Met Asp Asn Arg Ile Trp Gly Pro Gly Gly Leu Asp His Ser Gly 
    850                 855                 860                 


Arg Thr Leu Pro Ile Gly Gln Asn Phe Pro Ile Arg Gly Ile Gln Leu 
865                 870                 875                 880 


Tyr Asp Gly Pro Ile Asn Ile Gln Asn Cys Thr Phe Arg Lys Phe Val 
                885                 890                 895     


Ala Leu Glu Gly Arg His Thr Ser Ala Leu Ala Phe Arg Leu Asn Asn 
            900                 905                 910         


Ala Trp Gln Ser Cys Pro His Asn Asn Val Thr Gly Ile Ala Phe Glu 
        915                 920                 925             


Asp Val Pro Ile Thr Ser Arg Val Phe Phe Gly Glu Pro Gly Pro Trp 
    930                 935                 940                 


Phe Asn Gln Leu Asp Met Asp Gly Asp Lys Thr Ser Val Phe His Asp 
945                 950                 955                 960 


Val Asp Gly Ser Val Ser Glu Tyr Pro Gly Ser Tyr Leu Thr Lys Asn 
                965                 970                 975     


Asp Asn Trp Leu Val Arg His Pro Asp Cys Ile Asn Val Pro Asp Trp 
            980                 985                 990         


Arg Gly Ala Ile Cys Ser Gly Cys  Tyr Ala Gln Met Tyr  Ile Gln Ala 
        995                 1000                 1005             


Tyr Lys  Thr Ser Asn Leu Arg  Met Lys Ile Ile Lys  Asn Asp Phe 
    1010                 1015                 1020             


Pro Ser  His Pro Leu Tyr Leu  Glu Gly Ala Leu Thr  Arg Ser Thr 
    1025                 1030                 1035             


His Tyr  Gln Gln Tyr Gln Pro  Val Val Thr Leu Gln  Lys Gly Tyr 
    1040                 1045                 1050             


Thr Ile  His Trp Asp Gln Thr  Ala Pro Ala Glu Leu  Ala Ile Trp 
    1055                 1060                 1065             


Leu Ile  Asn Phe Asn Lys Gly  Asp Trp Ile Arg Val  Gly Leu Cys 
    1070                 1075                 1080             


Tyr Pro  Arg Gly Thr Thr Phe  Ser Ile Leu Ser Asp  Val His Asn 
    1085                 1090                 1095             


Arg Leu  Leu Lys Gln Thr Ser  Lys Thr Gly Val Phe  Val Arg Thr 
    1100                 1105                 1110             


Leu Gln  Met Asp Lys Val Glu  Gln Ser Tyr Pro Gly  Arg Ser His 
    1115                 1120                 1125             


Tyr Tyr  Trp Asp Glu Asp Ser  Gly Leu Leu Phe Leu  Lys Leu Lys 
    1130                 1135                 1140             


Ala Gln  Asn Glu Arg Glu Lys  Phe Ala Phe Cys Ser  Met Lys Gly 
    1145                 1150                 1155             


Cys Glu  Arg Ile Lys Ile Lys  Ala Leu Ile Pro Lys  Asn Ala Gly 
    1160                 1165                 1170             


Val Ser  Asp Cys Thr Ala Thr  Ala Tyr Pro Lys Phe  Thr Glu Arg 
    1175                 1180                 1185             


Ala Val  Val Asp Val Pro Met  Pro Lys Lys Leu Phe  Gly Ser Gln 
    1190                 1195                 1200             


Leu Lys  Thr Lys Asp His Phe  Leu Glu Val Lys Met  Glu Ser Ser 
    1205                 1210                 1215             


Lys Gln  His Phe Phe His Leu  Trp Asn Asp Phe Ala  Tyr Ile Glu 
    1220                 1225                 1230             


Val Asp  Gly Lys Lys Tyr Pro  Ser Ser Glu Asp Gly  Ile Gln Val 
    1235                 1240                 1245             


Val Val  Ile Asp Gly Asn Gln  Gly Arg Val Val Ser  His Thr Ser 
    1250                 1255                 1260             


Phe Arg  Asn Ser Ile Leu Gln  Gly Ile Pro Trp Gln  Leu Phe Asn 
    1265                 1270                 1275             


Tyr Val  Ala Thr Ile Pro Asp  Asn Ser Ile Val Leu  Met Ala Ser 
    1280                 1285                 1290             


Lys Gly  Arg Tyr Val Ser Arg  Gly Pro Trp Thr Arg  Val Leu Glu 
    1295                 1300                 1305             


Lys Leu  Gly Ala Asp Arg Gly  Leu Lys Leu Lys Glu  Gln Met Ala 
    1310                 1315                 1320             


Phe Val  Gly Phe Lys Gly Ser  Phe Arg Pro Ile Trp  Val Thr Leu 
    1325                 1330                 1335             


Asp Thr  Glu Asp His Lys Ala  Lys Ile Phe Gln Val  Val Pro Ile 
    1340                 1345                 1350             


Pro Val  Val Lys Lys Lys Lys  Leu 
    1355                 1360     

<210>  475
<211>  2279
<212>  DNA
<213>  Homo sapiens

<400>  475
tccggctctc ctttgtttat tttctaatct atatttttac tggaagattt cctctttatt     60

ctctcccgcc ctcctacaag cgctcttgct ggccgtctgg gtgcacacac cgctccctcg    120

atcaccccag cccccttcct ggtctcccga gcgcggggtt tgaaggtcac ctcctttcca    180

gtccccgtgc gagccgcgct gccgccgcct cctccagcca gagtcggtgg gactggctgc    240

gctgccctga agtggttctc caagcagcgc ggagggtggc ggacggcgga cggagcccag    300

gggccgcgtc gggtggggaa acccgaactc gcggagggga atccctcccc cttcgcccca    360

gccccccagc agcacccgcg gtggggcggg ggcgctctgc cagccccggg aacagcagag    420

gcggcggcac tggctggacc cacgcgcgcg cctccggggc tgaagaagga aggagtgagc    480

cgagccgagc accccacatc tggaggggac agccagccgt gggccccgcc ccggcgtccg    540

gagcaggaga attccgagct tcttgcccag gcagagagag caggagcgga ccgcgcgccc    600

gggattgaga gtccttgcgc tccagacccc cacccagtgg ccgccaggtc ccgcctgtcc    660

ggaccctcgc cgcgcccagg caggcgcgcc agggcggggc tgacctgccc gcgaagttgc    720

ggacagtgcg tgagaaacca gcaccccctt ccgccgcctc cagcttatgg tgagtgtggc    780

tgggggtgca gagagcgcac gggaattcgg gggtctgggg ccgagaacgt gaccgcagcc    840

gggctcgccg ggagttctag gaaactggtc aaagaactca tgcaagtgga acttacagct    900

tccttgatcg gactcagcat tcagatatca aagcagactg caatacctgc gtggaaatag    960

aagacagaaa ggtttcaaga caacagatga attgtgaaag agagcagcta aggggtaatc   1020

aggaagcagc cgctgcccct gacacaatgg ctcagcctta cgcttcggcc cagtttgctc   1080

ccccgcagaa cggtatcccc gcggaataca cggcccctca tccccacccc gcgccagagt   1140

acacaggcca gaccacggtt cccgagcaca cattaaacct gtaccctccc gcccagacgc   1200

actccgagca gagcccggcg gacacgagcg ctcagaccgt ctctggcacc gccacacaga   1260

cagatgacgc agcaccgacg gatggccagc cccagacaca accttctgaa aacacggaaa   1320

acaagtctca gcccaagcgg ctgcatgtct ccaatatccc cttcaggttc cgggatccgg   1380

acctcagaca aatgtttggt caatttggta aaatcttaga tgttgaaatt atttttaatg   1440

agcgaggctc aaagggattt ggtttcgtaa ctttcgaaaa tagtgccgat gcggacaggg   1500

cgagggagaa attacacggc accgtggtag agggccgtaa aatcgaggta aataatgcca   1560

cagcacgtgt aatgacaaat aaaaagaccg tcaaccctta tacaaatggc tggaaattga   1620

atccagttgt gggtgcagtc tacagtcccg aattctatgc aggcacggtc ctgttgtgcc   1680

aggccaacca ggagggatct tccatgtaca gtgcccccag ttcacttgta tatacttctg   1740

caatgccagg cttcccgtat ccagcagcca ccgccgcggc cgcctaccga ggggcgcacc   1800

tgcgaggccg cggtcgcacc gtgtacaaca ccttcagggc cgcggcgccc ccgcccccga   1860

tcccggccta cggcggtgtt gtttaccagg atggatttta tggtgcagac atttatggtg   1920

gttatgctgc ataccgctac gcccagccta cccctgccac tgccgctgcc tacagtgaca   1980

gttacggacg agtttatgct gccgacccct accaccacgc acttgctcca gcccccacct   2040

acggcgttgg tgccatgaat gcttttgcac ctttgactga tgccaagact aggagccatg   2100

ctgatgatgt gggtctcgtt ctttcttcat tgcaggctag tatataccga gggggataca   2160

accgttttgc tccatactaa atgacaaaac cataaaaacc ttccaatgtg gggagaaagg   2220

aagctttccg aggcctgagt attgcaatac atgcagtagt acatcatttt agcaactct    2279


<210>  476
<211>  397
<212>  PRT
<213>  Homo sapiens

<400>  476


Met Asn Cys Glu Arg Glu Gln Leu Arg Gly Asn Gln Glu Ala Ala Ala 
1               5                   10                  15      


Ala Pro Asp Thr Met Ala Gln Pro Tyr Ala Ser Ala Gln Phe Ala Pro 
            20                  25                  30          


Pro Gln Asn Gly Ile Pro Ala Glu Tyr Thr Ala Pro His Pro His Pro 
        35                  40                  45              


Ala Pro Glu Tyr Thr Gly Gln Thr Thr Val Pro Glu His Thr Leu Asn 
    50                  55                  60                  


Leu Tyr Pro Pro Ala Gln Thr His Ser Glu Gln Ser Pro Ala Asp Thr 
65                  70                  75                  80  


Ser Ala Gln Thr Val Ser Gly Thr Ala Thr Gln Thr Asp Asp Ala Ala 
                85                  90                  95      


Pro Thr Asp Gly Gln Pro Gln Thr Gln Pro Ser Glu Asn Thr Glu Asn 
            100                 105                 110         


Lys Ser Gln Pro Lys Arg Leu His Val Ser Asn Ile Pro Phe Arg Phe 
        115                 120                 125             


Arg Asp Pro Asp Leu Arg Gln Met Phe Gly Gln Phe Gly Lys Ile Leu 
    130                 135                 140                 


Asp Val Glu Ile Ile Phe Asn Glu Arg Gly Ser Lys Gly Phe Gly Phe 
145                 150                 155                 160 


Val Thr Phe Glu Asn Ser Ala Asp Ala Asp Arg Ala Arg Glu Lys Leu 
                165                 170                 175     


His Gly Thr Val Val Glu Gly Arg Lys Ile Glu Val Asn Asn Ala Thr 
            180                 185                 190         


Ala Arg Val Met Thr Asn Lys Lys Thr Val Asn Pro Tyr Thr Asn Gly 
        195                 200                 205             


Trp Lys Leu Asn Pro Val Val Gly Ala Val Tyr Ser Pro Glu Phe Tyr 
    210                 215                 220                 


Ala Gly Thr Val Leu Leu Cys Gln Ala Asn Gln Glu Gly Ser Ser Met 
225                 230                 235                 240 


Tyr Ser Ala Pro Ser Ser Leu Val Tyr Thr Ser Ala Met Pro Gly Phe 
                245                 250                 255     


Pro Tyr Pro Ala Ala Thr Ala Ala Ala Ala Tyr Arg Gly Ala His Leu 
            260                 265                 270         


Arg Gly Arg Gly Arg Thr Val Tyr Asn Thr Phe Arg Ala Ala Ala Pro 
        275                 280                 285             


Pro Pro Pro Ile Pro Ala Tyr Gly Gly Val Val Tyr Gln Asp Gly Phe 
    290                 295                 300                 


Tyr Gly Ala Asp Ile Tyr Gly Gly Tyr Ala Ala Tyr Arg Tyr Ala Gln 
305                 310                 315                 320 


Pro Thr Pro Ala Thr Ala Ala Ala Tyr Ser Asp Ser Tyr Gly Arg Val 
                325                 330                 335     


Tyr Ala Ala Asp Pro Tyr His His Ala Leu Ala Pro Ala Pro Thr Tyr 
            340                 345                 350         


Gly Val Gly Ala Met Asn Ala Phe Ala Pro Leu Thr Asp Ala Lys Thr 
        355                 360                 365             


Arg Ser His Ala Asp Asp Val Gly Leu Val Leu Ser Ser Leu Gln Ala 
    370                 375                 380                 


Ser Ile Tyr Arg Gly Gly Tyr Asn Arg Phe Ala Pro Tyr 
385                 390                 395         

<210>  477
<211>  3262
<212>  DNA
<213>  Homo sapiens

<400>  477
gaccttccat tttggtagct tcaactttgc agctgctgtg tctcttcgtc gtctgggaag     60

aaaactttca cattaagagt tgctgatgcg gattttcttt ctttcctctc ccggcgttga    120

tgagtgcttg gctcctgaca gaagggattt ggctcccagc tttgtagttc ggaagaagtt    180

gggtctatag atttccccct aactctccat tgatgtgttg agcttcagag ggaataataa    240

ctctacgtaa agcatgctgg cgtctcaagg agttctcctg catccttatg gcgtgcctat    300

gattgtaccg gcagctcctt accttcctgg actgattcag ggtaatcagg aagcagccgc    360

tgcccctgac acaatggctc agccttacgc ttcggcccag tttgctcccc cgcagaacgg    420

tatccccgcg gaatacacgg cccctcatcc ccaccccgcg ccagagtaca caggccagac    480

cacggttccc gagcacacat taaacctgta ccctcccgcc cagacgcact ccgagcagag    540

cccggcggac acgagcgctc agaccgtctc tggcaccgcc acacagacag atgacgcagc    600

accgacggat ggccagcccc agacacaacc ttctgaaaac acggaaaaca agtctcagcc    660

caagcggctg catgtctcca atatcccctt caggttccgg gatccggacc tcagacaaat    720

gtttggtcaa tttggtaaaa tcttagatgt tgaaattatt tttaatgagc gaggctcaaa    780

gggatttggt ttcgtaactt tcgaaaatag tgccgatgcg gacagggcga gggagaaatt    840

acacggcacc gtggtagagg gccgtaaaat cgaggtaaat aatgccacag cacgtgtaat    900

gacaaataaa aagaccgtca acccttatac aaatggctgg aaattgaatc cagttgtggg    960

tgcagtctac agtcccgaat tctatgcagg cacggtcctg ttgtgccagg ccaaccagga   1020

gggatcttcc atgtacagtg cccccagttc acttgtatat acttctgcaa tgccaggctt   1080

cccgtatcca gcagccaccg ccgcggccgc ctaccgaggg gcgcacctgc gaggccgcgg   1140

tcgcaccgtg tacaacacct tcagggccgc ggcgcccccg cccccgatcc cggcctacgg   1200

cggagtagtg tatcaagagc ctgtgtatgg caataaattg ctgcagggtg gttatgctgc   1260

ataccgctac gcccagccta cccctgccac tgccgctgcc tacagtgaca gttacggacg   1320

agtttatgct gccgacccct accaccacgc acttgctcca gcccccacct acggcgttgg   1380

tgccatgaat gcttttgcac ctttgactga tgccaagact aggagccatg ctgatgatgt   1440

gggtctcgtt ctttcttcat tgcaggctag tatataccga gggggataca accgttttgc   1500

tccatactaa atgacaaaac cataaaaacc ttccaatgtg gggagaaagg aagctttccg   1560

aggcctgagt attgcaatac atgcagtagt acatcatttt agcaactcta aaaaaaaaaa   1620

aaatacaaat aaaaaggaaa aaaaatgaca ttttttatct tatacctcag atattttgtt   1680

ctgtgtattt taatattgtg ggtctttaat ttctgaaggt tccgtagttt ggttgctggc   1740

tgtaggagtt tttgtggttg atctagacag atgctagata atgaataaaa actggtttag   1800

ggccatatcc agagtgctat attatgtaaa tgaattatat atgctgaata ttaagctact   1860

ggggttatca gctgtttggg aagagtgtaa gtgactacag tagtcatttt tttctgcacc   1920

tgcattattt tattttgtga aaggggaggt tgggaggggc ttaggggatt ggaactgggg   1980

tttggctgaa agaaaaaaaa aaaaatgtaa ctgatgaatc taaacgaccc actgcaccaa   2040

caatcattta tcaatggttc taagttactc attgccagtt caagccaaag gtcatgttgt   2100

taagggggtg cttctagtag cacttgtgca tctgagttga atgaagctgt gcaaacccac   2160

cctttaaacc attccacccg gcagtattca gcttcttaac cagtcgctat ttaggaaaaa   2220

aaacccacta gttaggccat caacaagcat tctttttata tttcttccag tataataaat   2280

tattgatatc actgctgact tttatattat gggagggaaa aaataacatt aataaaaagg   2340

tgataaaaaa gcactgtttc tatttttttc tttttttcca aaaaaagaaa gtaataaaaa   2400

cttaaattct ttgtaccagt taaaaaaaat gtataaaatt tacatctgtg cagtggagtt   2460

gttaagttct agaaacagtc tatgaagctt tagttttagc ctagtagaac aactgttaga   2520

gacagacgta taatttttat ggaattacat gataatcata ttcggattta tagaagcatt   2580

ttacaagtat tgcaatcatt gagtagagat aatcatggta ttttcatcag cttggtactt   2640

tttgaaacgt gactgcgttg tgtgaacaat ctgcaatttt tcagtccgtg agatcctgcc   2700

cttccacctc tttcccatac ccccaaggat tatctcaaaa tgatctcttt agttctgtct   2760

ccaaggccca ggacacttgt cagaaggatg caaaaaaaga aaaaagtaca tccaccctct   2820

taatcccaaa agaacaaagt ctccccacct ttctcggatg cagggccaga gtgacacagc   2880

cgaaaaattg cagtttgtct gtacttctgt ttgaactttc cacgttgtcc tgtttacaag   2940

ttaacttaag ttggggtatc cgtcacgggt cttcctgttt tgtatttaaa taaaaacaac   3000

agcagcaggc tgtccctgag tagttttgct gccataggtt aagtcctcat gtgtacagtg   3060

caggccctgt ggcccgcact tcagtaagtt atcaactctc accgctgtga acctgccaat   3120

ccgctgtaac aactctgctt taaaacaaaa ccaaacaaaa ctttaaaaaa aaatgtgtga   3180

tccagctttc tcttgccatc ctatgtgcat gccgtaagat cagttggata ttaaaccatc   3240

aataaagttt cacaagattt ga                                            3262


<210>  478
<211>  418
<212>  PRT
<213>  Homo sapiens

<400>  478


Met Leu Ala Ser Gln Gly Val Leu Leu His Pro Tyr Gly Val Pro Met 
1               5                   10                  15      


Ile Val Pro Ala Ala Pro Tyr Leu Pro Gly Leu Ile Gln Gly Asn Gln 
            20                  25                  30          


Glu Ala Ala Ala Ala Pro Asp Thr Met Ala Gln Pro Tyr Ala Ser Ala 
        35                  40                  45              


Gln Phe Ala Pro Pro Gln Asn Gly Ile Pro Ala Glu Tyr Thr Ala Pro 
    50                  55                  60                  


His Pro His Pro Ala Pro Glu Tyr Thr Gly Gln Thr Thr Val Pro Glu 
65                  70                  75                  80  


His Thr Leu Asn Leu Tyr Pro Pro Ala Gln Thr His Ser Glu Gln Ser 
                85                  90                  95      


Pro Ala Asp Thr Ser Ala Gln Thr Val Ser Gly Thr Ala Thr Gln Thr 
            100                 105                 110         


Asp Asp Ala Ala Pro Thr Asp Gly Gln Pro Gln Thr Gln Pro Ser Glu 
        115                 120                 125             


Asn Thr Glu Asn Lys Ser Gln Pro Lys Arg Leu His Val Ser Asn Ile 
    130                 135                 140                 


Pro Phe Arg Phe Arg Asp Pro Asp Leu Arg Gln Met Phe Gly Gln Phe 
145                 150                 155                 160 


Gly Lys Ile Leu Asp Val Glu Ile Ile Phe Asn Glu Arg Gly Ser Lys 
                165                 170                 175     


Gly Phe Gly Phe Val Thr Phe Glu Asn Ser Ala Asp Ala Asp Arg Ala 
            180                 185                 190         


Arg Glu Lys Leu His Gly Thr Val Val Glu Gly Arg Lys Ile Glu Val 
        195                 200                 205             


Asn Asn Ala Thr Ala Arg Val Met Thr Asn Lys Lys Thr Val Asn Pro 
    210                 215                 220                 


Tyr Thr Asn Gly Trp Lys Leu Asn Pro Val Val Gly Ala Val Tyr Ser 
225                 230                 235                 240 


Pro Glu Phe Tyr Ala Gly Thr Val Leu Leu Cys Gln Ala Asn Gln Glu 
                245                 250                 255     


Gly Ser Ser Met Tyr Ser Ala Pro Ser Ser Leu Val Tyr Thr Ser Ala 
            260                 265                 270         


Met Pro Gly Phe Pro Tyr Pro Ala Ala Thr Ala Ala Ala Ala Tyr Arg 
        275                 280                 285             


Gly Ala His Leu Arg Gly Arg Gly Arg Thr Val Tyr Asn Thr Phe Arg 
    290                 295                 300                 


Ala Ala Ala Pro Pro Pro Pro Ile Pro Ala Tyr Gly Gly Val Val Tyr 
305                 310                 315                 320 


Gln Glu Pro Val Tyr Gly Asn Lys Leu Leu Gln Gly Gly Tyr Ala Ala 
                325                 330                 335     


Tyr Arg Tyr Ala Gln Pro Thr Pro Ala Thr Ala Ala Ala Tyr Ser Asp 
            340                 345                 350         


Ser Tyr Gly Arg Val Tyr Ala Ala Asp Pro Tyr His His Ala Leu Ala 
        355                 360                 365             


Pro Ala Pro Thr Tyr Gly Val Gly Ala Met Asn Ala Phe Ala Pro Leu 
    370                 375                 380                 


Thr Asp Ala Lys Thr Arg Ser His Ala Asp Asp Val Gly Leu Val Leu 
385                 390                 395                 400 


Ser Ser Leu Gln Ala Ser Ile Tyr Arg Gly Gly Tyr Asn Arg Phe Ala 
                405                 410                 415     


Pro Tyr 
        

<210>  479
<211>  3184
<212>  DNA
<213>  Homo sapiens

<400>  479
gaccttccat tttggtagct tcaactttgc agctgctgtg tctcttcgtc gtctgggaag     60

aaaactttca cattaagagt tgctgatgcg gattttcttt ctttcctctc ccggcgttga    120

tgagtgcttg gctcctgaca gaagggattt ggctcccagc tttgtagttc ggaagaagtt    180

gggtctatag atttccccct aactctccat tgatgtgttg agcttcagag ggaataataa    240

ctctacgtaa agcatgctgg cgtctcaagg agttctcctg catccttatg gcgtgcctat    300

gattgtaccg gcagctcctt accttcctgg actgattcag ggtaatcagg aagcagccgc    360

tgcccctgac acaatggctc agccttacgc ttcggcccag tttgctcccc cgcagaacgg    420

tatccccgcg gaatacacgg cccctcatcc ccaccccgcg ccagagtaca caggccagac    480

cacggttccc gagcacacat taaacctgta ccctcccgcc cagacgcact ccgagcagag    540

cccggcggac acgagcgctc agaccgtctc tggcaccgcc acacagacag atgacgcagc    600

accgacggat ggccagcccc agacacaacc ttctgaaaac acggaaaaca agtctcagcc    660

caagcggctg catgtctcca atatcccctt caggttccgg gatccggacc tcagacaaat    720

gtttggtcaa tttggtaaaa tcttagatgt tgaaattatt tttaatgagc gaggctcaaa    780

gggatttggt ttcgtaactt tcgaaaatag tgccgatgcg gacagggcga gggagaaatt    840

acacggcacc gtggtagagg gccgtaaaat cgaggtaaat aatgccacag cacgtgtaat    900

gacaaataaa aagaccgtca acccttatac aaatggctgg aaattgaatc cagttgtggg    960

tgcagtctac agtcccgaat tctatgcagg cacggtcctg ttgtgccagg ccaaccagga   1020

gggatcttcc atgtacagtg cccccagttc acttgtatat acttctgcaa tgccaggctt   1080

cccgtatcca gcagccaccg ccgcggccgc ctaccgaggg gcgcacctgc gaggccgcgg   1140

tcgcaccgtg tacaacacct tcagggccgc ggcgcccccg cccccgatcc cggcctacgg   1200

cggagtagtg tatcaagagc ctgtgtatgg caataaattg ctgcagggtg gttatgctgc   1260

ataccgctac gcccagccta cccctgccac tgccgctgcc tacagtgaca gttacggacg   1320

agtttatgct gccgacccct accaccacgc acttgctcca gcccccacct acggcgttgg   1380

tgccatggct agtatatacc gagggggata caaccgtttt gctccatact aaatgacaaa   1440

accataaaaa ccttccaatg tggggagaaa ggaagctttc cgaggcctga gtattgcaat   1500

acatgcagta gtacatcatt ttagcaactc taaaaaaaaa aaaaatacaa ataaaaagga   1560

aaaaaaatga cattttttat cttatacctc agatattttg ttctgtgtat tttaatattg   1620

tgggtcttta atttctgaag gttccgtagt ttggttgctg gctgtaggag tttttgtggt   1680

tgatctagac agatgctaga taatgaataa aaactggttt agggccatat ccagagtgct   1740

atattatgta aatgaattat atatgctgaa tattaagcta ctggggttat cagctgtttg   1800

ggaagagtgt aagtgactac agtagtcatt tttttctgca cctgcattat tttattttgt   1860

gaaaggggag gttgggaggg gcttagggga ttggaactgg ggtttggctg aaagaaaaaa   1920

aaaaaaatgt aactgatgaa tctaaacgac ccactgcacc aacaatcatt tatcaatggt   1980

tctaagttac tcattgccag ttcaagccaa aggtcatgtt gttaaggggg tgcttctagt   2040

agcacttgtg catctgagtt gaatgaagct gtgcaaaccc accctttaaa ccattccacc   2100

cggcagtatt cagcttctta accagtcgct atttaggaaa aaaaacccac tagttaggcc   2160

atcaacaagc attcttttta tatttcttcc agtataataa attattgata tcactgctga   2220

cttttatatt atgggaggga aaaaataaca ttaataaaaa ggtgataaaa aagcactgtt   2280

tctatttttt tctttttttc caaaaaaaga aagtaataaa aacttaaatt ctttgtacca   2340

gttaaaaaaa atgtataaaa tttacatctg tgcagtggag ttgttaagtt ctagaaacag   2400

tctatgaagc tttagtttta gcctagtaga acaactgtta gagacagacg tataattttt   2460

atggaattac atgataatca tattcggatt tatagaagca ttttacaagt attgcaatca   2520

ttgagtagag ataatcatgg tattttcatc agcttggtac tttttgaaac gtgactgcgt   2580

tgtgtgaaca atctgcaatt tttcagtccg tgagatcctg cccttccacc tctttcccat   2640

acccccaagg attatctcaa aatgatctct ttagttctgt ctccaaggcc caggacactt   2700

gtcagaagga tgcaaaaaaa gaaaaaagta catccaccct cttaatccca aaagaacaaa   2760

gtctccccac ctttctcgga tgcagggcca gagtgacaca gccgaaaaat tgcagtttgt   2820

ctgtacttct gtttgaactt tccacgttgt cctgtttaca agttaactta agttggggta   2880

tccgtcacgg gtcttcctgt tttgtattta aataaaaaca acagcagcag gctgtccctg   2940

agtagttttg ctgccatagg ttaagtcctc atgtgtacag tgcaggccct gtggcccgca   3000

cttcagtaag ttatcaactc tcaccgctgt gaacctgcca atccgctgta acaactctgc   3060

tttaaaacaa aaccaaacaa aactttaaaa aaaaatgtgt gatccagctt tctcttgcca   3120

tcctatgtgc atgccgtaag atcagttgga tattaaacca tcaataaagt ttcacaagat   3180

ttga                                                                3184


<210>  480
<211>  392
<212>  PRT
<213>  Homo sapiens

<400>  480


Met Leu Ala Ser Gln Gly Val Leu Leu His Pro Tyr Gly Val Pro Met 
1               5                   10                  15      


Ile Val Pro Ala Ala Pro Tyr Leu Pro Gly Leu Ile Gln Gly Asn Gln 
            20                  25                  30          


Glu Ala Ala Ala Ala Pro Asp Thr Met Ala Gln Pro Tyr Ala Ser Ala 
        35                  40                  45              


Gln Phe Ala Pro Pro Gln Asn Gly Ile Pro Ala Glu Tyr Thr Ala Pro 
    50                  55                  60                  


His Pro His Pro Ala Pro Glu Tyr Thr Gly Gln Thr Thr Val Pro Glu 
65                  70                  75                  80  


His Thr Leu Asn Leu Tyr Pro Pro Ala Gln Thr His Ser Glu Gln Ser 
                85                  90                  95      


Pro Ala Asp Thr Ser Ala Gln Thr Val Ser Gly Thr Ala Thr Gln Thr 
            100                 105                 110         


Asp Asp Ala Ala Pro Thr Asp Gly Gln Pro Gln Thr Gln Pro Ser Glu 
        115                 120                 125             


Asn Thr Glu Asn Lys Ser Gln Pro Lys Arg Leu His Val Ser Asn Ile 
    130                 135                 140                 


Pro Phe Arg Phe Arg Asp Pro Asp Leu Arg Gln Met Phe Gly Gln Phe 
145                 150                 155                 160 


Gly Lys Ile Leu Asp Val Glu Ile Ile Phe Asn Glu Arg Gly Ser Lys 
                165                 170                 175     


Gly Phe Gly Phe Val Thr Phe Glu Asn Ser Ala Asp Ala Asp Arg Ala 
            180                 185                 190         


Arg Glu Lys Leu His Gly Thr Val Val Glu Gly Arg Lys Ile Glu Val 
        195                 200                 205             


Asn Asn Ala Thr Ala Arg Val Met Thr Asn Lys Lys Thr Val Asn Pro 
    210                 215                 220                 


Tyr Thr Asn Gly Trp Lys Leu Asn Pro Val Val Gly Ala Val Tyr Ser 
225                 230                 235                 240 


Pro Glu Phe Tyr Ala Gly Thr Val Leu Leu Cys Gln Ala Asn Gln Glu 
                245                 250                 255     


Gly Ser Ser Met Tyr Ser Ala Pro Ser Ser Leu Val Tyr Thr Ser Ala 
            260                 265                 270         


Met Pro Gly Phe Pro Tyr Pro Ala Ala Thr Ala Ala Ala Ala Tyr Arg 
        275                 280                 285             


Gly Ala His Leu Arg Gly Arg Gly Arg Thr Val Tyr Asn Thr Phe Arg 
    290                 295                 300                 


Ala Ala Ala Pro Pro Pro Pro Ile Pro Ala Tyr Gly Gly Val Val Tyr 
305                 310                 315                 320 


Gln Glu Pro Val Tyr Gly Asn Lys Leu Leu Gln Gly Gly Tyr Ala Ala 
                325                 330                 335     


Tyr Arg Tyr Ala Gln Pro Thr Pro Ala Thr Ala Ala Ala Tyr Ser Asp 
            340                 345                 350         


Ser Tyr Gly Arg Val Tyr Ala Ala Asp Pro Tyr His His Ala Leu Ala 
        355                 360                 365             


Pro Ala Pro Thr Tyr Gly Val Gly Ala Met Ala Ser Ile Tyr Arg Gly 
    370                 375                 380                 


Gly Tyr Asn Arg Phe Ala Pro Tyr 
385                 390         

<210>  481
<211>  3315
<212>  DNA
<213>  Homo sapiens

<400>  481
gaccttccat tttggtagct tcaactttgc agctgctgtg tctcttcgtc gtctgggaag     60

aaaactttca cattaagagt tgctgatgcg gattttcttt ctttcctctc ccggcgttga    120

tgagtgcttg gctcctgaca gaagggattt ggctcccagc tttgtagttc ggaagaagtt    180

gggtctatag atttccccct aactctccat tgatgtgttg agcttcagag ggaataataa    240

ctctacgtaa agcatgctgg cgtctcaagg agttctcctg catccttatg gcgtgcctat    300

gattgtaccg gcagctcctt accttcctgg actgattcag ggtaatcagg aagcagccgc    360

tgcccctgac acaatggctc agccttacgc ttcggcccag tttgctcccc cgcagaacgg    420

tatccccgcg gaatacacgg cccctcatcc ccaccccgcg ccagagtaca caggccagac    480

cacggttccc gagcacacat taaacctgta ccctcccgcc cagacgcact ccgagcagag    540

cccggcggac acgagcgctc agaccgtctc tggcaccgcc acacagacag atgacgcagc    600

accgacggat ggccagcccc agacacaacc ttctgaaaac acggaaaaca agtctcagcc    660

caagcggctg catgtctcca atatcccctt caggttccgg gatccggacc tcagacaaat    720

gtttggtcaa tttggtaaaa tcttagatgt tgaaattatt tttaatgagc gaggctcaaa    780

gggatttggt ttcgtaactt tcgaaaatag tgccgatgcg gacagggcga gggagaaatt    840

acacggcacc gtggtagagg gccgtaaaat cgaggtaaat aatgccacag cacgtgtaat    900

gacaaataaa aagaccgtca acccttatac aaatggctgg aaattgaatc cagttgtggg    960

tgcagtctac agtcccgaat tctatgcagg cacggtcctg ttgtgccagg ccaaccagga   1020

gggatcttcc atgtacagtg cccccagttc acttgtatat acttctgcaa tgccaggctt   1080

cccgtatcca gcagccaccg ccgcggccgc ctaccgaggg gcgcacctgc gaggccgcgg   1140

tcgcaccgtg tacaacacct tcagggccgc ggcgcccccg cccccgatcc cggcctacgg   1200

cggagtagtg tatcaagagc ctgtgtatgg caataaattg ctgcagggtg gttatgctgc   1260

ataccgctac gcccagccta cccctgccac tgccgctgcc tacagtgaca gaaatcagtt   1320

cgtcttcgtt gcagcagatg aaatttcttg taacacctct gcagttacgg acgagtttat   1380

gctgccgacc cctaccacca cgcacttgct ccagccccca cctacggcgt tggtgccatg   1440

aatgcttttg cacctttgac tgatgccaag actaggagcc atgctgatga tgtgggtctc   1500

gttctttctt cattgcaggc tagtatatac cgagggggat acaaccgttt tgctccatac   1560

taaatgacaa aaccataaaa accttccaat gtggggagaa aggaagcttt ccgaggcctg   1620

agtattgcaa tacatgcagt agtacatcat tttagcaact ctaaaaaaaa aaaaaataca   1680

aataaaaagg aaaaaaaatg acatttttta tcttatacct cagatatttt gttctgtgta   1740

ttttaatatt gtgggtcttt aatttctgaa ggttccgtag tttggttgct ggctgtagga   1800

gtttttgtgg ttgatctaga cagatgctag ataatgaata aaaactggtt tagggccata   1860

tccagagtgc tatattatgt aaatgaatta tatatgctga atattaagct actggggtta   1920

tcagctgttt gggaagagtg taagtgacta cagtagtcat ttttttctgc acctgcatta   1980

ttttattttg tgaaagggga ggttgggagg ggcttagggg attggaactg gggtttggct   2040

gaaagaaaaa aaaaaaaatg taactgatga atctaaacga cccactgcac caacaatcat   2100

ttatcaatgg ttctaagtta ctcattgcca gttcaagcca aaggtcatgt tgttaagggg   2160

gtgcttctag tagcacttgt gcatctgagt tgaatgaagc tgtgcaaacc caccctttaa   2220

accattccac ccggcagtat tcagcttctt aaccagtcgc tatttaggaa aaaaaaccca   2280

ctagttaggc catcaacaag cattcttttt atatttcttc cagtataata aattattgat   2340

atcactgctg acttttatat tatgggaggg aaaaaataac attaataaaa aggtgataaa   2400

aaagcactgt ttctattttt ttcttttttt ccaaaaaaag aaagtaataa aaacttaaat   2460

tctttgtacc agttaaaaaa aatgtataaa atttacatct gtgcagtgga gttgttaagt   2520

tctagaaaca gtctatgaag ctttagtttt agcctagtag aacaactgtt agagacagac   2580

gtataatttt tatggaatta catgataatc atattcggat ttatagaagc attttacaag   2640

tattgcaatc attgagtaga gataatcatg gtattttcat cagcttggta ctttttgaaa   2700

cgtgactgcg ttgtgtgaac aatctgcaat ttttcagtcc gtgagatcct gcccttccac   2760

ctctttccca tacccccaag gattatctca aaatgatctc tttagttctg tctccaaggc   2820

ccaggacact tgtcagaagg atgcaaaaaa agaaaaaagt acatccaccc tcttaatccc   2880

aaaagaacaa agtctcccca cctttctcgg atgcagggcc agagtgacac agccgaaaaa   2940

ttgcagtttg tctgtacttc tgtttgaact ttccacgttg tcctgtttac aagttaactt   3000

aagttggggt atccgtcacg ggtcttcctg ttttgtattt aaataaaaac aacagcagca   3060

ggctgtccct gagtagtttt gctgccatag gttaagtcct catgtgtaca gtgcaggccc   3120

tgtggcccgc acttcagtaa gttatcaact ctcaccgctg tgaacctgcc aatccgctgt   3180

aacaactctg ctttaaaaca aaaccaaaca aaactttaaa aaaaaatgtg tgatccagct   3240

ttctcttgcc atcctatgtg catgccgtaa gatcagttgg atattaaacc atcaataaag   3300

tttcacaaga tttga                                                    3315


<210>  482
<211>  395
<212>  PRT
<213>  Homo sapiens

<400>  482


Met Leu Ala Ser Gln Gly Val Leu Leu His Pro Tyr Gly Val Pro Met 
1               5                   10                  15      


Ile Val Pro Ala Ala Pro Tyr Leu Pro Gly Leu Ile Gln Gly Asn Gln 
            20                  25                  30          


Glu Ala Ala Ala Ala Pro Asp Thr Met Ala Gln Pro Tyr Ala Ser Ala 
        35                  40                  45              


Gln Phe Ala Pro Pro Gln Asn Gly Ile Pro Ala Glu Tyr Thr Ala Pro 
    50                  55                  60                  


His Pro His Pro Ala Pro Glu Tyr Thr Gly Gln Thr Thr Val Pro Glu 
65                  70                  75                  80  


His Thr Leu Asn Leu Tyr Pro Pro Ala Gln Thr His Ser Glu Gln Ser 
                85                  90                  95      


Pro Ala Asp Thr Ser Ala Gln Thr Val Ser Gly Thr Ala Thr Gln Thr 
            100                 105                 110         


Asp Asp Ala Ala Pro Thr Asp Gly Gln Pro Gln Thr Gln Pro Ser Glu 
        115                 120                 125             


Asn Thr Glu Asn Lys Ser Gln Pro Lys Arg Leu His Val Ser Asn Ile 
    130                 135                 140                 


Pro Phe Arg Phe Arg Asp Pro Asp Leu Arg Gln Met Phe Gly Gln Phe 
145                 150                 155                 160 


Gly Lys Ile Leu Asp Val Glu Ile Ile Phe Asn Glu Arg Gly Ser Lys 
                165                 170                 175     


Gly Phe Gly Phe Val Thr Phe Glu Asn Ser Ala Asp Ala Asp Arg Ala 
            180                 185                 190         


Arg Glu Lys Leu His Gly Thr Val Val Glu Gly Arg Lys Ile Glu Val 
        195                 200                 205             


Asn Asn Ala Thr Ala Arg Val Met Thr Asn Lys Lys Thr Val Asn Pro 
    210                 215                 220                 


Tyr Thr Asn Gly Trp Lys Leu Asn Pro Val Val Gly Ala Val Tyr Ser 
225                 230                 235                 240 


Pro Glu Phe Tyr Ala Gly Thr Val Leu Leu Cys Gln Ala Asn Gln Glu 
                245                 250                 255     


Gly Ser Ser Met Tyr Ser Ala Pro Ser Ser Leu Val Tyr Thr Ser Ala 
            260                 265                 270         


Met Pro Gly Phe Pro Tyr Pro Ala Ala Thr Ala Ala Ala Ala Tyr Arg 
        275                 280                 285             


Gly Ala His Leu Arg Gly Arg Gly Arg Thr Val Tyr Asn Thr Phe Arg 
    290                 295                 300                 


Ala Ala Ala Pro Pro Pro Pro Ile Pro Ala Tyr Gly Gly Val Val Tyr 
305                 310                 315                 320 


Gln Glu Pro Val Tyr Gly Asn Lys Leu Leu Gln Gly Gly Tyr Ala Ala 
                325                 330                 335     


Tyr Arg Tyr Ala Gln Pro Thr Pro Ala Thr Ala Ala Ala Tyr Ser Asp 
            340                 345                 350         


Arg Asn Gln Phe Val Phe Val Ala Ala Asp Glu Ile Ser Cys Asn Thr 
        355                 360                 365             


Ser Ala Val Thr Asp Glu Phe Met Leu Pro Thr Pro Thr Thr Thr His 
    370                 375                 380                 


Leu Leu Gln Pro Pro Pro Thr Ala Leu Val Pro 
385                 390                 395 

<210>  483
<211>  3581
<212>  DNA
<213>  Homo sapiens

<400>  483
gggggcggcg gcggctggag agggtcctcg gcagcctctg aggagcgcgg ggcgcggcca     60

tgagcgagtc cagcggcagt gcgctccagc ccggcaggcc cagccggcag caggcggtcc    120

atccagagaa cctctctcta gactccagtt gcttctcttc tccacctgtg aacttcctcc    180

aagaattgcc aagctaccgg tccattgcac gtaggagaac gactgtccat tcccgggaca    240

agcaaagcgg aactttgcta aagccaaccg actcttacag ctcccagctg gaggacagaa    300

tcgctgaaaa cctcagcagc cattctcttc gaaattatgc actgaacatc tctgagaagc    360

ggagactaag ggacattcaa gagacacaaa tgaagtatct ctccgaatgg gaccagtgga    420

agcggtatag cagcaagtct tggaagaggt tcctagagaa ggctcgagag atgacgaccc    480

acctggagct gtggcgggag gacatccgca gcatagaagg gaaatttggc actgggattc    540

agtcctattt ctccttcttg agattcctgg tgttgctgaa tttggtgata tttctgatca    600

tctttatgct ggttttgctc ccagtcttac tcacgaaata caagatcacc aacagcagct    660

tcgtgctcat tcctttcaaa gacatggata aacaatgtac agtctatcca gtaagcagtt    720

ctggactcat ttacttttac agttatatca tagacttgct ttctggcact ggtttcctgg    780

aggaaactag cctcttttac ggacattaca ccattgatga ggtgaaattt cagaacttca    840

cctatgatct gcccctggcg tatttgttaa gcacaatcgc ctccctggcc ctgagccttc    900

tttggatagt gaaaaggtcg gtggaaggat tcaaaatcaa cctgattcgg agtgaggagc    960

actttcagag ttactgcaac aagatatttg ccggctggga cttctgcatc actaaccgca   1020

gcatggcgga tctgaagcac agcagcttgc ggtacgagct ccgagcagat ctggaggaag   1080

aaagaatgcg gcagaaaata gcagaaagga cctcagaaga aacaatacgc atttactctt   1140

tgagactgtt tttgaactgt attgttctgg ctgttttagg ggcatgcttt tatgcaatat   1200

acgtagcaac tgtcttctcg caagagcaca tgaaaaagga aatcgacaag atggtttttg   1260

gagagaacct cttcatattg tatctaccgt ctattgtgat cacgctggcc aattttatca   1320

ccccaatgat ctttgccaag atcatccgct atgaggatta ttctccaggc tttgagatcc   1380

gtctgacaat ccttaggtgt gtctttatgc ggctggccac catatgtgtc ctggtgttca   1440

cgctgggctc caagatcaca tcctgtgatg atgacacatg tgacctttgc ggctacaacc   1500

agaaactcta cccgtgctgg gagacccaag ttgggcagga aatgtacaag ctgatgatct   1560

tcgacttcat catcatcttg gctgtgacac tcttcgtgga ttttcctaga aagctcctgg   1620

tgacctactg ttcctcttgc aagctgattc agtgctgggg gcagcaggag tttgccattc   1680

ctgataacgt cctggggata gtttacgggc aaaccatctg ctggatcgga gcctttttct   1740

caccccttct ccctgcaatt gcaaccctga aattcattat catcttctat gtgaaagagt   1800

ggagtctgct ttacacctgc agaccctccc ccaggccgtt cagagcatcc aattctaatt   1860

tcttcttcct gttggtgttg ttgatcgggc tgtgtttggc aataatacct ctgacaatca   1920

gcatatcacg catcccttcc tcgaaagcct gtgggccgtt caccaacttc aacaccacct   1980

gggaggtcat ccccaagaca gtgagcacct tccccagctc gctgcagtcc ttcatccatg   2040

gtgtcacatc cgaagccttt gcagttcctt tcttcatgat tatttgcctc atcatgtttt   2100

acttcattgc cttagctgga gcacacaaac gggtggtcat ccagctccga gagcagctat   2160

ccctggaaag tcgtgacaag tgctacctaa tccagaaact aacagaagcc caaagggaca   2220

tgaggaacta actagactga gcgtgaagat ggtgctgcct gttgcttcta agctgaccta   2280

gtgattctgc tgagcctaca gagtctacct gggttttgag tggacattta aaaatatatt   2340

tttcttgagt ttaggctttt ccatatgtgc agctgtgttt acctaaccca gcccttaatt   2400

agggcttcag tgacttagaa aagcagggga aacccaaggc tttgcctgca gaccggccac   2460

actgtgacaa ctctaccaaa aaccaacaag ccattcaagc ttttacaaga atgaaagagc   2520

ggagacggta gtttagtatt tgagccacga gtttatgtgc acaagtgttt tgggttgtgg   2580

actgaagctc agcctgttaa tcagaccagc ccatgagtgt ataacaaaca gaattggagg   2640

ctggtttctt aaacacacac gtccacattt tttagggttg ttttcctgtg cttacaattt   2700

ttaatgcatg tgcctttatt tcacaaaaca tgtggctggg cgcagcggct cacgcctgtt   2760

atcccaacac tttgggaggc cgaggcaggc ggagcaccta agttggggag ttcaagacct   2820

gcctgaccaa cgtggagaaa ctccgtctcc actaaaatac aaaattagct gggtgtggtg   2880

gcacatgcct gtaatatcag ctactcagga ggctgaggca ggagaattgc ttgaacccag   2940

gaggtggagt ttgcagtgag ctgagatcac accattgcac tccagcctgg gcaaaaagag   3000

caaaactctc cctaaaaaaa aaatgtagaa tatctcttaa gatttccgtt atggtaaaaa   3060

ccatatgcaa taaatacctc attgtaagct tacccaaaat tgatagatgt caacctttta   3120

acagaagaac agaagtttaa gttattgttt aatgtaatca gttttcattt taatatcttt   3180

gaaatctttt tcaaaggact gtagttttgt aatggacttt tcaagccttc cttccattgt   3240

ttttcttccg ttcactggct ccacacgttt cctggggagt agcctggaat ttaaagttgg   3300

gtgcaggttt tagaaagctg ttgctgttaa caataattct cccggccatc tccactccac   3360

tactcaaaaa tgcctgaatc cttgctcaga ggagcaaagg tatcttctcg tccctttctt   3420

acagccattt tcttgctttt ccacaaagat attatttaaa gtggaatatt tttgtaactg   3480

ggataccaat gagcttttcg gtcttttcct gacttggtaa ggtttatggg tttctaaatc   3540

taataactac agtcatacca ccccgaaaaa aaaaaaaaaa a                       3581


<210>  484
<211>  723
<212>  PRT
<213>  Homo sapiens

<400>  484


Met Ser Glu Ser Ser Gly Ser Ala Leu Gln Pro Gly Arg Pro Ser Arg 
1               5                   10                  15      


Gln Gln Ala Val His Pro Glu Asn Leu Ser Leu Asp Ser Ser Cys Phe 
            20                  25                  30          


Ser Ser Pro Pro Val Asn Phe Leu Gln Glu Leu Pro Ser Tyr Arg Ser 
        35                  40                  45              


Ile Ala Arg Arg Arg Thr Thr Val His Ser Arg Asp Lys Gln Ser Gly 
    50                  55                  60                  


Thr Leu Leu Lys Pro Thr Asp Ser Tyr Ser Ser Gln Leu Glu Asp Arg 
65                  70                  75                  80  


Ile Ala Glu Asn Leu Ser Ser His Ser Leu Arg Asn Tyr Ala Leu Asn 
                85                  90                  95      


Ile Ser Glu Lys Arg Arg Leu Arg Asp Ile Gln Glu Thr Gln Met Lys 
            100                 105                 110         


Tyr Leu Ser Glu Trp Asp Gln Trp Lys Arg Tyr Ser Ser Lys Ser Trp 
        115                 120                 125             


Lys Arg Phe Leu Glu Lys Ala Arg Glu Met Thr Thr His Leu Glu Leu 
    130                 135                 140                 


Trp Arg Glu Asp Ile Arg Ser Ile Glu Gly Lys Phe Gly Thr Gly Ile 
145                 150                 155                 160 


Gln Ser Tyr Phe Ser Phe Leu Arg Phe Leu Val Leu Leu Asn Leu Val 
                165                 170                 175     


Ile Phe Leu Ile Ile Phe Met Leu Val Leu Leu Pro Val Leu Leu Thr 
            180                 185                 190         


Lys Tyr Lys Ile Thr Asn Ser Ser Phe Val Leu Ile Pro Phe Lys Asp 
        195                 200                 205             


Met Asp Lys Gln Cys Thr Val Tyr Pro Val Ser Ser Ser Gly Leu Ile 
    210                 215                 220                 


Tyr Phe Tyr Ser Tyr Ile Ile Asp Leu Leu Ser Gly Thr Gly Phe Leu 
225                 230                 235                 240 


Glu Glu Thr Ser Leu Phe Tyr Gly His Tyr Thr Ile Asp Glu Val Lys 
                245                 250                 255     


Phe Gln Asn Phe Thr Tyr Asp Leu Pro Leu Ala Tyr Leu Leu Ser Thr 
            260                 265                 270         


Ile Ala Ser Leu Ala Leu Ser Leu Leu Trp Ile Val Lys Arg Ser Val 
        275                 280                 285             


Glu Gly Phe Lys Ile Asn Leu Ile Arg Ser Glu Glu His Phe Gln Ser 
    290                 295                 300                 


Tyr Cys Asn Lys Ile Phe Ala Gly Trp Asp Phe Cys Ile Thr Asn Arg 
305                 310                 315                 320 


Ser Met Ala Asp Leu Lys His Ser Ser Leu Arg Tyr Glu Leu Arg Ala 
                325                 330                 335     


Asp Leu Glu Glu Glu Arg Met Arg Gln Lys Ile Ala Glu Arg Thr Ser 
            340                 345                 350         


Glu Glu Thr Ile Arg Ile Tyr Ser Leu Arg Leu Phe Leu Asn Cys Ile 
        355                 360                 365             


Val Leu Ala Val Leu Gly Ala Cys Phe Tyr Ala Ile Tyr Val Ala Thr 
    370                 375                 380                 


Val Phe Ser Gln Glu His Met Lys Lys Glu Ile Asp Lys Met Val Phe 
385                 390                 395                 400 


Gly Glu Asn Leu Phe Ile Leu Tyr Leu Pro Ser Ile Val Ile Thr Leu 
                405                 410                 415     


Ala Asn Phe Ile Thr Pro Met Ile Phe Ala Lys Ile Ile Arg Tyr Glu 
            420                 425                 430         


Asp Tyr Ser Pro Gly Phe Glu Ile Arg Leu Thr Ile Leu Arg Cys Val 
        435                 440                 445             


Phe Met Arg Leu Ala Thr Ile Cys Val Leu Val Phe Thr Leu Gly Ser 
    450                 455                 460                 


Lys Ile Thr Ser Cys Asp Asp Asp Thr Cys Asp Leu Cys Gly Tyr Asn 
465                 470                 475                 480 


Gln Lys Leu Tyr Pro Cys Trp Glu Thr Gln Val Gly Gln Glu Met Tyr 
                485                 490                 495     


Lys Leu Met Ile Phe Asp Phe Ile Ile Ile Leu Ala Val Thr Leu Phe 
            500                 505                 510         


Val Asp Phe Pro Arg Lys Leu Leu Val Thr Tyr Cys Ser Ser Cys Lys 
        515                 520                 525             


Leu Ile Gln Cys Trp Gly Gln Gln Glu Phe Ala Ile Pro Asp Asn Val 
    530                 535                 540                 


Leu Gly Ile Val Tyr Gly Gln Thr Ile Cys Trp Ile Gly Ala Phe Phe 
545                 550                 555                 560 


Ser Pro Leu Leu Pro Ala Ile Ala Thr Leu Lys Phe Ile Ile Ile Phe 
                565                 570                 575     


Tyr Val Lys Glu Trp Ser Leu Leu Tyr Thr Cys Arg Pro Ser Pro Arg 
            580                 585                 590         


Pro Phe Arg Ala Ser Asn Ser Asn Phe Phe Phe Leu Leu Val Leu Leu 
        595                 600                 605             


Ile Gly Leu Cys Leu Ala Ile Ile Pro Leu Thr Ile Ser Ile Ser Arg 
    610                 615                 620                 


Ile Pro Ser Ser Lys Ala Cys Gly Pro Phe Thr Asn Phe Asn Thr Thr 
625                 630                 635                 640 


Trp Glu Val Ile Pro Lys Thr Val Ser Thr Phe Pro Ser Ser Leu Gln 
                645                 650                 655     


Ser Phe Ile His Gly Val Thr Ser Glu Ala Phe Ala Val Pro Phe Phe 
            660                 665                 670         


Met Ile Ile Cys Leu Ile Met Phe Tyr Phe Ile Ala Leu Ala Gly Ala 
        675                 680                 685             


His Lys Arg Val Val Ile Gln Leu Arg Glu Gln Leu Ser Leu Glu Ser 
    690                 695                 700                 


Arg Asp Lys Cys Tyr Leu Ile Gln Lys Leu Thr Glu Ala Gln Arg Asp 
705                 710                 715                 720 


Met Arg Asn 
            

<210>  485
<211>  833
<212>  DNA
<213>  Homo sapiens

<400>  485
ctgtctgtcc ccctggacag gtatgttggg tggagcaggg cgggcagtca gcgagcgtgc     60

tgcccctgtg tcatggacag gtccttgggg gctcaacctg gcctgttggg gttggtggcc    120

ctgctgttgt gttgggggag gaggtcagct gcagggctgg aagcttagct gtcagggctg    180

cggaggacct gtggggtgag gttgctgctc aagaaggagg ctcttcaggg accagggaac    240

aagagggagt gaccagcaaa ccccagagag agctaatcat gccccagaac tgcagcgcgc    300

ctgtgcctat ggaaggaggg tcccccatgt gggctgagca gggctgtccg agacaggatg    360

tgcagccccc cggtactggt gagctggggg gtcctgcagc cccatggctg cgaatcacaa    420

gatgcttgga tttagacact tttggacttt tcacatcact tgttggattc caaaccaggc    480

acttctggct gcctccctgc cttccctctc tcttgcccac tcacacgtgt tctttttgcc    540

gctcttgtct ctcacagacg ttctttctct tcctctccct ccccacgtcc cttccccccc    600

accctctccc tgaggaagga aaaaattcag tctctcacaa acaaaatatc tgccattcca    660

tcggagggag aactgaggca ggagcccaga atatcctgga aggaacgcaa gcgagagttg    720

aaggcctcag ttgtttaatc tggaaggagg actttgatgt caccctgctc cgtttatcct    780

gggaagcttc ccgctgcttc atggcttcga ctctctgtgt gaaagatggc tga           833


<210>  486
<211>  184
<212>  PRT
<213>  Homo sapiens

<400>  486


Met Pro Gln Asn Cys Ser Ala Pro Val Pro Met Glu Gly Gly Ser Pro 
1               5                   10                  15      


Met Trp Ala Glu Gln Gly Cys Pro Arg Gln Asp Val Gln Pro Pro Gly 
            20                  25                  30          


Thr Gly Glu Leu Gly Gly Pro Ala Ala Pro Trp Leu Arg Ile Thr Arg 
        35                  40                  45              


Cys Leu Asp Leu Asp Thr Phe Gly Leu Phe Thr Ser Leu Val Gly Phe 
    50                  55                  60                  


Gln Thr Arg His Phe Trp Leu Pro Pro Cys Leu Pro Ser Leu Leu Pro 
65                  70                  75                  80  


Thr His Thr Cys Ser Phe Cys Arg Ser Cys Leu Ser Gln Thr Phe Phe 
                85                  90                  95      


Leu Phe Leu Ser Leu Pro Thr Ser Leu Pro Pro His Pro Leu Pro Glu 
            100                 105                 110         


Glu Gly Lys Asn Ser Val Ser His Lys Gln Asn Ile Cys His Ser Ile 
        115                 120                 125             


Gly Gly Arg Thr Glu Ala Gly Ala Gln Asn Ile Leu Glu Gly Thr Gln 
    130                 135                 140                 


Ala Arg Val Glu Gly Leu Ser Cys Leu Ile Trp Lys Glu Asp Phe Asp 
145                 150                 155                 160 


Val Thr Leu Leu Arg Leu Ser Trp Glu Ala Ser Arg Cys Phe Met Ala 
                165                 170                 175     


Ser Thr Leu Cys Val Lys Asp Gly 
            180                 

<210>  487
<211>  423
<212>  DNA
<213>  Homo sapiens

<400>  487
atgtggccat tcagactccg gtgtcccatt tacttcaaaa ccaggctact ttattcctcg     60

agtcaggatg gcttcctctc ctcctccacc aattattata atcatcgaac atatcctggg    120

cttgtaaact ggctgtttgt gttaacagag cccgagttga caggggagct gggagacgat    180

gacaggaaag ggatgcacac aggtggcatc attagatggc tgggacgccc cagcagccaa    240

ttgaagccca tctttcatgc agaagagaga cgggtgccac cgccccctga aaggctggta    300

ggcagagctt ccccgaggga acaggcaaca gtcttcaaga gaatctgcgc acctcttcat    360

gctgaggtct tctgcagagc ggggctctgc gcctgccacc ctgactgcac tgcagccggg    420

tga                                                                  423


<210>  488
<211>  140
<212>  PRT
<213>  Homo sapiens

<400>  488


Met Trp Pro Phe Arg Leu Arg Cys Pro Ile Tyr Phe Lys Thr Arg Leu 
1               5                   10                  15      


Leu Tyr Ser Ser Ser Gln Asp Gly Phe Leu Ser Ser Ser Thr Asn Tyr 
            20                  25                  30          


Tyr Asn His Arg Thr Tyr Pro Gly Leu Val Asn Trp Leu Phe Val Leu 
        35                  40                  45              


Thr Glu Pro Glu Leu Thr Gly Glu Leu Gly Asp Asp Asp Arg Lys Gly 
    50                  55                  60                  


Met His Thr Gly Gly Ile Ile Arg Trp Leu Gly Arg Pro Ser Ser Gln 
65                  70                  75                  80  


Leu Lys Pro Ile Phe His Ala Glu Glu Arg Arg Val Pro Pro Pro Pro 
                85                  90                  95      


Glu Arg Leu Val Gly Arg Ala Ser Pro Arg Glu Gln Ala Thr Val Phe 
            100                 105                 110         


Lys Arg Ile Cys Ala Pro Leu His Ala Glu Val Phe Cys Arg Ala Gly 
        115                 120                 125             


Leu Cys Ala Cys His Pro Asp Cys Thr Ala Ala Gly 
    130                 135                 140 

<210>  489
<211>  348
<212>  DNA
<213>  Homo sapiens

<400>  489
ggcaccgtct acaaacgggg tttaaaatga gctagcgcca tctactgggc gaatgccgta     60

aggtcggttg tgaggtcccg gaatctgcaa aggaatgaat gaattacaaa tctgtggctt    120

tatgggggga atgtcgagaa tcgggcacac gctgaagtgt gagaaccact gccattatgg    180

agaagaggct tcccgccccc tcacctgcca ctctagaaat ccagagaaga gattccactt    240

ggattaagac ttgcataagt ggggagttga gtccagtctc tttcccccac tgcaataccc    300

tgttgcggtg acatgtaata ataataaaaa gacttgcatg aactcctt                 348


<210>  490
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  490


Met Ser Arg Ile Gly His Thr Leu Lys Cys Glu Asn His Cys His Tyr 
1               5                   10                  15      


Gly Glu Glu Ala Ser Arg Pro Leu Thr Cys His Ser Arg Asn Pro Glu 
            20                  25                  30          


Lys Arg Phe His Leu Asp 
        35              

<210>  491
<211>  718
<212>  DNA
<213>  Homo sapiens

<400>  491
taaccaggac aaatggatag tgctttgggg atgactacca gaataaatca gttctaaacc     60

ttttccatat ttgtgtcact tcgctcagga cttcatttcc ctgtagggag agactggtgg    120

acttagcttg tggcaacaat taacactgtg tgccagagag gagggcagga tacctgaatt    180

gaaggttcca tcaagagcac aggcaggggt gattgaacca agccttcacc gcaccgagtt    240

tgccctactg cagtcaccca caccgcggct cgcttacggt tggagaaatc aaggccctac    300

cggggccacc tctctgttgt gggcgtggac gaggctgggg tgagcctgcc ggagctgcag    360

ttgccagcga catgttcaag gtaattcaga agggtccgtg gggccagcca gccggagctt    420

gttcaccttc agagtctgtg cagcaccgaa aaaggactca cctcccaaaa cttccgtgaa    480

ggttgacgag ctttcgcgag ggcaaatcgc agtgtgtgga ggagtcaagg aaccagcttg    540

aagaaagctt ctcacagctc cgacacttat tgcgagccat acacaagctg gtgtcaggac    600

acgtactccc aaagtcccac caatcccgta ctagctgtgg cttccaaaaa caagcacttg    660

agggctttct ctggcattct gggctggtga tagacacaag gattgcaggg cttgatat      718


<210>  492
<211>  4273
<212>  DNA
<213>  Homo sapiens

<400>  492
gactcccggg tccccgcgcc ggactgggac tgggagcagg cagcccgggc ggagcgggcc     60

ggtgccgagg acggccccag gcattgctct gccccgggca ttgcgcggcg cgcgtgaggg    120

ggatgcggca ggaggcggcg cggcgggagg agtaggcggc ggcgccctcg ggagggagct    180

gcgcgcgggc cagacggcgc ccggaggctc cgcagtgccg ccgccgtcgc ccgggaggct    240

ccgcgcggga gccatgtaac cctgcggcgg gctccgggct gctccgtcct tccccagctc    300

ccgggctagc gcggcagcgg ggccacgatg aagaagcagt tcaatcgcat gcgccagctg    360

gccaaccaga cggtgggcag ggctgaaaag acagaagttt tgagtgaaga ccttcttcag    420

gtggagaagc gtctggagct ggtgaaacag gtgtcccaca gcacgcacaa gaagctcacc    480

gcatgtctgc agggccagca aggggcagag gctgacaagc gctccaaaaa gttgcctttg    540

acaacactgg ctcagtgtct gatggagggg tcagctatcc tgggagatga cacacttctt    600

gggaagatgc tgaaactctg tggagagacg gaggacaagc tggctcagga gctgatacat    660

tttgagttgc aagtagagag agacgtgatt gagcccctgt ttttgctggc ggaggtggaa    720

atcccaaata ttcaaaagca gaggaaacac ttagccaagt tggtgctgga catggattcc    780

tcacgaacca ggtggcagca gacttccaag tcttcaggtt tgtccagcag cttacagcct    840

gcgggtgcca aggctgatgc cctcagggaa gaaatggaag aggctgccaa cagagtggag    900

atttgcaggg accagctctc agctgatatg tacagttttg tggccaaaga aattgactat    960

gcaaactact ttcaaacgct aatagaagtg caagctgaat accacaggaa gtccctgaca   1020

ctattgcagg ctgtattgcc tcagatcaaa gcacaacagg aggcctgggt agagaagcct   1080

tccttcggga agccgctgga ggagcacctc accatcagcg gccgggagat cgccttcccc   1140

atcgaggcgt gtgtgaccat gctgcttgag tgtgggatgc aggaggaggg actcttccga   1200

gtagccccct ctgcctccaa actgaagaag ctgaaagcgg ccctggactg ctgcgtggtg   1260

gatgtgcagg agtactcggc agacccccac gcaattgcag gagctttgaa atcttacctc   1320

cgagagttgc cagaacctct tatgaccttt gaactctatg atgagtggat ccaggcttcc   1380

aatgtccagg agcaagacaa gaagcttcag gctctatgga atgcttgtga aaagttgccc   1440

aaggccaatc acaacaacat ccgatacttg ataaaatttt tatccaagct gtcagaatat   1500

caagatgtaa acaagatgac tcccagtaat atggcaattg ttttaggacc caacctccta   1560

tggccacaag cagaagggaa cattacagag atgatgacca cagtgtcgct gcaaattgtt   1620

gggatcattg aacctatcat ccagcatgca gactggttct tccctgggga gatagagttc   1680

aacattactg gcaattatgg gagtccagta cacgtgaacc ataatgccaa ctacagctca   1740

atgccctccc cagacatgga ccctgctgac cggcgccagc ccgagcaggc ccgccggccc   1800

ctcagcgtcg ccacggataa tatgatgctg gagttttaca aaaaggatgg ccttaggaaa   1860

atccaaagca tgggtgtgag ggtcatggac acaaactggg tggctcgaag aggctcctcg   1920

gccggtcgga aagtgtcctg cgccccgccc tccatgcagc ctcccgcccc gcccgccgag   1980

ctggctgcgc ccctgccttc gccgctgccg gagcagcccc tggacagccc cgcggccccc   2040

gcgctctctc catccggcct gggcctccag cctgggcccg agcgcaccag cacaacaaaa   2100

agcaaggaac tttctccagg ctctgcacag aaaggaagtc caggctccag ccagggcaca   2160

gcctgtgcag ggactcaacc aggggctcaa cctggagctc agccgggcgc cagccccagc   2220

cccagccagc cgcctgcaga ccagagtcct cacaccctcc ggaaagtttc aaagaagctg   2280

gcaccgattc cacccaaggt cccctttggc cagccggggg ctatggcaga ccagtccgct   2340

ggccagccgt ccccagtcag cctgtccccc accccgccca gcaccccgtc accctatgga   2400

ctgagctacc ctcaggggta ctccttggcc tcgggccagc tctccccagc tgcagctcct   2460

cccctggcct ctccttctgt ctttacaagc actttgagca aatcgcggcc cactcctaag   2520

ccgcgacaga gacctactct gccgcctcct cagcctccca cagtaaacct ctcggcctct   2580

agtccacagt ccacggaggc ccccatgcta gatggcatgt cccctgggga aagcatgtct   2640

acagatcttg tccactttga tattccctcg atccacatag agctcgggtc gacgctccgc   2700

ctgagtcccc tggagcacat gcggcgacac tcagtaactg acaagaggga ctcggaggag   2760

gagtctgaga gcaccgccct ctgacatgac accgcccatc ctgcctcgcg tgtacataca   2820

tcacgggccc taggaacgcc gccaggagca gcgtccatga gcttgccaag tgttctctgc   2880

tggctctttc ctgccactgc caacacgagg ttggaatttg gcagaaaatt gtgatctcca   2940

gtccgtgtgg tgatgctggt ggtgcaggtt ttgtttgttc ctttcgggtg gtgacttcgg   3000

ccttttgttt gacctttgcc ttttgacttt gtgcctcttt tgatccactt tcagcctcca   3060

tgccagaaaa cacccacctc tccatccaag gctggtcagg aacgtccttt gcagggtcgg   3120

ggtggtgcgg gagaggctca ctttgcctgg ttagacccaa gggctgctac cttttccttg   3180

gacggctcat gtcaggtctt gcaggatcag tttaatggcc acagaaagga agcaggacag   3240

cagggcccct ctcacccaca actggaccag gtccaggatt ctagcagtcc tggggcactg   3300

acctttgcca gctacctggg ggagggcttg ccactggaaa acctttcagg ccgcccccat   3360

cagtgggctc caaagtaaat ggctgaaaac aaaaatgttt cacttcctaa cagttttcct   3420

ttttccactg tgtgactgaa agctcctata tcattttata tttctgaatc tataaaacaa   3480

aacaaacaag cctgacagtg tctggaggag ccaaaggtgg cctccctgtc cccaaatata   3540

ttggctatat gagagtaatt ttacccctct acgtacctaa aggcacccag ttcactagtc   3600

tgtggggtcc tggagcctgt ctcttctttc tggaggttca aactgaatag caataattac   3660

gttacccaaa gcatgtggag gaaaagtgaa accagccacg gagacgctgg cccacgggct   3720

cggcctgcgg tgtggcctgc tttgctcacc agcgtcagcc gctcatttcc ttctcatgaa   3780

gtcccatctg gtcatgggga cgagggccgg gagggcaccg ggtagccttt tcacacttgg   3840

ggattagggg agtgagaaaa gatttgggcc atgcatgcaa agtcaaagtt taaaatttta   3900

tccttttcaa atagatgata taatatacct atacatgata taatatttgt atatatgaaa   3960

tctctctata tttgtttaat ttgagccatt caatctaaac caatgtacag gtgtacaatg   4020

aaaaatttaa atgcttagtt atttttccca acacagtgta aagtcaccct cctctgagag   4080

tgggatgtgc agagttttga tgttgcagct ttgctcactt cctggcaagg gcaggtcatg   4140

cctcaatttg taatgggagt ctggggtaag ggtgggggtt gaaagttgtt atctttaaat   4200

acatgtacaa atcgttgtca aaagtaacgt tattaaaata gatttattat ccctgaaaaa   4260

aaaaaaaaaa aaa                                                      4273


<210>  493
<211>  818
<212>  PRT
<213>  Homo sapiens

<400>  493


Met Lys Lys Gln Phe Asn Arg Met Arg Gln Leu Ala Asn Gln Thr Val 
1               5                   10                  15      


Gly Arg Ala Glu Lys Thr Glu Val Leu Ser Glu Asp Leu Leu Gln Val 
            20                  25                  30          


Glu Lys Arg Leu Glu Leu Val Lys Gln Val Ser His Ser Thr His Lys 
        35                  40                  45              


Lys Leu Thr Ala Cys Leu Gln Gly Gln Gln Gly Ala Glu Ala Asp Lys 
    50                  55                  60                  


Arg Ser Lys Lys Leu Pro Leu Thr Thr Leu Ala Gln Cys Leu Met Glu 
65                  70                  75                  80  


Gly Ser Ala Ile Leu Gly Asp Asp Thr Leu Leu Gly Lys Met Leu Lys 
                85                  90                  95      


Leu Cys Gly Glu Thr Glu Asp Lys Leu Ala Gln Glu Leu Ile His Phe 
            100                 105                 110         


Glu Leu Gln Val Glu Arg Asp Val Ile Glu Pro Leu Phe Leu Leu Ala 
        115                 120                 125             


Glu Val Glu Ile Pro Asn Ile Gln Lys Gln Arg Lys His Leu Ala Lys 
    130                 135                 140                 


Leu Val Leu Asp Met Asp Ser Ser Arg Thr Arg Trp Gln Gln Thr Ser 
145                 150                 155                 160 


Lys Ser Ser Gly Leu Ser Ser Ser Leu Gln Pro Ala Gly Ala Lys Ala 
                165                 170                 175     


Asp Ala Leu Arg Glu Glu Met Glu Glu Ala Ala Asn Arg Val Glu Ile 
            180                 185                 190         


Cys Arg Asp Gln Leu Ser Ala Asp Met Tyr Ser Phe Val Ala Lys Glu 
        195                 200                 205             


Ile Asp Tyr Ala Asn Tyr Phe Gln Thr Leu Ile Glu Val Gln Ala Glu 
    210                 215                 220                 


Tyr His Arg Lys Ser Leu Thr Leu Leu Gln Ala Val Leu Pro Gln Ile 
225                 230                 235                 240 


Lys Ala Gln Gln Glu Ala Trp Val Glu Lys Pro Ser Phe Gly Lys Pro 
                245                 250                 255     


Leu Glu Glu His Leu Thr Ile Ser Gly Arg Glu Ile Ala Phe Pro Ile 
            260                 265                 270         


Glu Ala Cys Val Thr Met Leu Leu Glu Cys Gly Met Gln Glu Glu Gly 
        275                 280                 285             


Leu Phe Arg Val Ala Pro Ser Ala Ser Lys Leu Lys Lys Leu Lys Ala 
    290                 295                 300                 


Ala Leu Asp Cys Cys Val Val Asp Val Gln Glu Tyr Ser Ala Asp Pro 
305                 310                 315                 320 


His Ala Ile Ala Gly Ala Leu Lys Ser Tyr Leu Arg Glu Leu Pro Glu 
                325                 330                 335     


Pro Leu Met Thr Phe Glu Leu Tyr Asp Glu Trp Ile Gln Ala Ser Asn 
            340                 345                 350         


Val Gln Glu Gln Asp Lys Lys Leu Gln Ala Leu Trp Asn Ala Cys Glu 
        355                 360                 365             


Lys Leu Pro Lys Ala Asn His Asn Asn Ile Arg Tyr Leu Ile Lys Phe 
    370                 375                 380                 


Leu Ser Lys Leu Ser Glu Tyr Gln Asp Val Asn Lys Met Thr Pro Ser 
385                 390                 395                 400 


Asn Met Ala Ile Val Leu Gly Pro Asn Leu Leu Trp Pro Gln Ala Glu 
                405                 410                 415     


Gly Asn Ile Thr Glu Met Met Thr Thr Val Ser Leu Gln Ile Val Gly 
            420                 425                 430         


Ile Ile Glu Pro Ile Ile Gln His Ala Asp Trp Phe Phe Pro Gly Glu 
        435                 440                 445             


Ile Glu Phe Asn Ile Thr Gly Asn Tyr Gly Ser Pro Val His Val Asn 
    450                 455                 460                 


His Asn Ala Asn Tyr Ser Ser Met Pro Ser Pro Asp Met Asp Pro Ala 
465                 470                 475                 480 


Asp Arg Arg Gln Pro Glu Gln Ala Arg Arg Pro Leu Ser Val Ala Thr 
                485                 490                 495     


Asp Asn Met Met Leu Glu Phe Tyr Lys Lys Asp Gly Leu Arg Lys Ile 
            500                 505                 510         


Gln Ser Met Gly Val Arg Val Met Asp Thr Asn Trp Val Ala Arg Arg 
        515                 520                 525             


Gly Ser Ser Ala Gly Arg Lys Val Ser Cys Ala Pro Pro Ser Met Gln 
    530                 535                 540                 


Pro Pro Ala Pro Pro Ala Glu Leu Ala Ala Pro Leu Pro Ser Pro Leu 
545                 550                 555                 560 


Pro Glu Gln Pro Leu Asp Ser Pro Ala Ala Pro Ala Leu Ser Pro Ser 
                565                 570                 575     


Gly Leu Gly Leu Gln Pro Gly Pro Glu Arg Thr Ser Thr Thr Lys Ser 
            580                 585                 590         


Lys Glu Leu Ser Pro Gly Ser Ala Gln Lys Gly Ser Pro Gly Ser Ser 
        595                 600                 605             


Gln Gly Thr Ala Cys Ala Gly Thr Gln Pro Gly Ala Gln Pro Gly Ala 
    610                 615                 620                 


Gln Pro Gly Ala Ser Pro Ser Pro Ser Gln Pro Pro Ala Asp Gln Ser 
625                 630                 635                 640 


Pro His Thr Leu Arg Lys Val Ser Lys Lys Leu Ala Pro Ile Pro Pro 
                645                 650                 655     


Lys Val Pro Phe Gly Gln Pro Gly Ala Met Ala Asp Gln Ser Ala Gly 
            660                 665                 670         


Gln Pro Ser Pro Val Ser Leu Ser Pro Thr Pro Pro Ser Thr Pro Ser 
        675                 680                 685             


Pro Tyr Gly Leu Ser Tyr Pro Gln Gly Tyr Ser Leu Ala Ser Gly Gln 
    690                 695                 700                 


Leu Ser Pro Ala Ala Ala Pro Pro Leu Ala Ser Pro Ser Val Phe Thr 
705                 710                 715                 720 


Ser Thr Leu Ser Lys Ser Arg Pro Thr Pro Lys Pro Arg Gln Arg Pro 
                725                 730                 735     


Thr Leu Pro Pro Pro Gln Pro Pro Thr Val Asn Leu Ser Ala Ser Ser 
            740                 745                 750         


Pro Gln Ser Thr Glu Ala Pro Met Leu Asp Gly Met Ser Pro Gly Glu 
        755                 760                 765             


Ser Met Ser Thr Asp Leu Val His Phe Asp Ile Pro Ser Ile His Ile 
    770                 775                 780                 


Glu Leu Gly Ser Thr Leu Arg Leu Ser Pro Leu Glu His Met Arg Arg 
785                 790                 795                 800 


His Ser Val Thr Asp Lys Arg Asp Ser Glu Glu Glu Ser Glu Ser Thr 
                805                 810                 815     


Ala Leu 
        

<210>  494
<211>  3997
<212>  DNA
<213>  Homo sapiens

<400>  494
attccgcatt cctagcctgg cggcgcgcgc ggctccttaa tgagactcgg gccaagggcc     60

gacctcgcga ttccgctcgc ccctatttta tgtttgattt ttccttccca acgccggcta    120

gcgctgggac ccgaatgggg ccggccagct gcggcgggag gagcctccac ctccctcagc    180

tgcgtttctc cagggtagac gccaccgcag tcactgatgt cccttttcaa aggatgcacg    240

ctccccaccg ggcgccggag gtgttttgca gccgctcttc cagaggcgcg ggtagggggc    300

accctacccc cacccccaga gttcgctggg cactggctgg gaatcagcct cgctgctgtg    360

cccagctcct ctcgggccgc gggggctctg gggctcagct tcgtgcggga tgggtccggg    420

gcgcagctgt gggaaaccta tttattctgt tgctggggaa ggaagacgga gaagaggagg    480

ggacagtgct ttcctacagt agtatggtgc atatctccaa catcacaggc attgtaggta    540

caacagtgag caggacaaaa ccagctcttg tcctcatgga actaactttc tagaggggaa    600

ggcagacact aagcttctaa ttgcttgcaa ttgtggtgtg atttggcatc atgcacttcg    660

ctcatcttat ggagaagact gaggcctgtg gttggaaagg gcgagggagc agcctgctat    720

ctttagagaa cacagtttca gcctcaagtt cttcctgtac ctccgatatg gatctaccct    780

tcctggattg aagccttgtg ccaagtccat gggcctgatg atcctctgac tctccaaatg    840

ccagattttc ctcctccttg cctcagggaa gtgaagggca gccgatagcc cacctggaga    900

ataaaatatg actacaacct gcagtgctcc atggacctgt cattctcagc agtgtaaatc    960

ctactgctca gagagaaggc agttggcaca aggtagacag ccagttgttt cagctattcc   1020

aatcctgcat gtcatttacc tggaaagggg ttctatacat tccctctgcc tttcctacta   1080

ccccagcaga ctgccctcgg tctcacctgt tagtcctagt tacggattcc caaacagcaa   1140

tgccactgga gcttagataa ggggaagtca gaggagccac cccaactgga gcccgggctg   1200

gagagaggac ctggcatgtg tgtactcttc tatcccagat gagcacctta tcaacttaag   1260

gtggtagtgt ctctgctgtt tccattctgt ttgtgtcttc tggacagagg attggcaatg   1320

gttggaggtt atctcagtca ccagttccca ggtgatgcct ggaagaaccc tgtcctcctg   1380

ccaagaagcc aggcagcaag tggggttctg tcccaggccc cggtgcccta catggatgct   1440

tatcaaggac ccatacataa actggcaccc acttcctccc atgcctgacc tgccctcatg   1500

ataggccagg tgacatctgt ccttcagcat gcctctgttt ttcagaatgt ctaccatcag   1560

gagacaatca gatgagccaa tgtggagcat catgaagaca tgttcctggg atcatcctgg   1620

aatccgactc tgtctcagct caagggggtt ccgagatttc ctaagctagc cctctcattt   1680

tacagctgca aaaacggagg cctgttaatt cagtcatttt atgaaatcct ttgaaatttt   1740

tattgagctc taattgtgtg tgaagtatta tggaatgctt ctgtactgga atgcataggt   1800

tgaacaagac agaaaggccc agatggcaga agttcaagag ctttcaccaa cccatataga   1860

gaacctagta atattaatga ctaatgttaa tgaatccatg ctttttacgt gccagtcact   1920

gtgcccagca ttttgcatgc attatctgag tcctcactac aacgctgtta cgtaggtact   1980

gttattataa ccattttcca gatgagaaaa ctgaggctca gtgaaggcaa gtttcttgcc   2040

tagggtcata gagctataaa gtagcagagt cacagctcaa aagcacatat atgtgattcc   2100

aaagctcaga tacgtaaccc atttagccac tttcactgtg atatgcaagg gcccaggatt   2160

tcatatatag caaagctatc atttctgggt ggacatgttt aggggcagtg gggtaccagg   2220

cataaatagg ctgttcaaca cggggagggc agtgtgtgaa ggaggccagc acaggggctc   2280

tgggaacaca ggcacctctg atgagaaagt agtgttcttt ctgcagtact gttctgagta   2340

gctcagcctc ttgttcccct tccccagcac ccagattcac acctacatgc tgttagacat   2400

tcaccccatt tagtacacag ttatgcatac acgtggctat tgtagcaatt gtcgaacttt   2460

caccctgcag ctgggctgct ttgccttccc ctgtaggctg agctcccagc ttagattcca   2520

gcaccaatag ctatttgtgg gacaggagaa tgtcagcagt gaagggcagc atgatggcca   2580

gcatgtggct ttcccaagca gagacctggg ttccagtcct agaaggcaag gcaactgtat   2640

tagtttgctc atgctgctgt gacaaaatac tacagaccaa atggcttaaa cgacagaagt   2700

ttttttttct caccgttctg gaggctggag tccaagatca gcgtgctggc agggttggtt   2760

tccccttagg actctttcct tagctagaag atggacacct tcttgctatg ttttcacata   2820

cggtcatttt tctgtgttca tgaatcatgg tttatcttcc tcttcttata aggacgctag   2880

tcatattgga tttgggcccc atgaaaatgg ttcattttaa cttactcacc tctttaaaga   2940

cgttagctcc aaagattgtt gtatgctgag ttacttgggg ttggaacttc aacgtatgaa   3000

ttttggaggt agaagatata tttgagagta aaaaggggtt ctgttaaccc atttatgcct   3060

gaggttgcaa ttttttgaag ttttgcaatc agatcttggc aatgacctgg agcggtagga   3120

tataaataat tcccacatgc ttagcattcc aataatggaa cactaggcat aaatgggcta   3180

aaaattactt tggagcagca gtcttaaatg gaccatttag ggcaaactgg aacatatgga   3240

caccctaaca ttctggcccc atcactcact ctacagccat cttcttttaa accactgcac   3300

ctctctgagt ctcagtttct tcatctgttg aatggagata atcatatcaa ctcccccaag   3360

caggcacttt taaaatacta gtaaatgcat actgattacc tgacagtact gagcaccact   3420

gcatgctctg taaaggttaa ccattgctat tattgaaacc aaactgctca ctgaggtcta   3480

tgggcctatg tgatttgacc cctagctgct tttccaaatt catttcttcc cccttccccc   3540

ttctcccttc tattttatta cactggcacc acaaaggccg cccagcagtc atatatcaag   3600

cacattcctg cctcagggcc tttgtacctg ttgttccctc cacctggaat gttttcccct   3660

aaccccttgc tcctttactt cattcaggtt tttgcccaac tgccacttcc tcagagatac   3720

cttccgagat atatgatgag ctgatataaa ataatgcaac tattgttcta cctccattgc   3780

tttattcttt tatgctactt taattggatt catagcagtt ggtattttat tttagaattg   3840

cctgtgtatc tatctgtctc ttctgataga atgtaagctc cccaagggcc aagattctgt   3900

atgaaccatt caccaacgta tccccagtgc ccagaatggt gcctggcata tgtgcttaac   3960

aaaataaact gactggatta tttatccata ttcactt                            3997


<210>  495
<211>  167
<212>  PRT
<213>  Homo sapiens

<400>  495


Met Phe Asp Phe Ser Phe Pro Thr Pro Ala Ser Ala Gly Thr Arg Met 
1               5                   10                  15      


Gly Pro Ala Ser Cys Gly Gly Arg Ser Leu His Leu Pro Gln Leu Arg 
            20                  25                  30          


Phe Ser Arg Val Asp Ala Thr Ala Val Thr Asp Val Pro Phe Gln Arg 
        35                  40                  45              


Met His Ala Pro His Arg Ala Pro Glu Val Phe Cys Ser Arg Ser Ser 
    50                  55                  60                  


Arg Gly Ala Gly Arg Gly His Pro Thr Pro Thr Pro Arg Val Arg Trp 
65                  70                  75                  80  


Ala Leu Ala Gly Asn Gln Pro Arg Cys Cys Ala Gln Leu Leu Ser Gly 
                85                  90                  95      


Arg Gly Gly Ser Gly Ala Gln Leu Arg Ala Gly Trp Val Arg Gly Ala 
            100                 105                 110         


Ala Val Gly Asn Leu Phe Ile Leu Leu Leu Gly Lys Glu Asp Gly Glu 
        115                 120                 125             


Glu Glu Gly Thr Val Leu Ser Tyr Ser Ser Met Val His Ile Ser Asn 
    130                 135                 140                 


Ile Thr Gly Ile Val Gly Thr Thr Val Ser Arg Thr Lys Pro Ala Leu 
145                 150                 155                 160 


Val Leu Met Glu Leu Thr Phe 
                165         

<210>  496
<211>  4369
<212>  DNA
<213>  Homo sapiens

<400>  496
cccccgggac gcccgcggcc accgggctcc ggactgcacg tgcagctccc cccgcgcctc     60

gcagatcctg cagggggcac cagctggggg aggtggaggc tcctcccgcc cggagctgcg    120

cccccaccgg ctccgagggt gtagccgcca gcgcctggga cgccccctcc ccgcaaagtg    180

tccccgaatt gcactctctg gtcccggagc tgcatctgag acagccgggc gccacggcag    240

ccctgagttg gatgtgacca agcccagcct ggggccaagt cgtcgtcgac tgttgctctc    300

tcggacccct cccgcccccg cctcggccat ggccccgggg atgtcgggcc gcggcggcgc    360

cgccctgctc tgcctctcag cgctactcgc ccacgcctct ggccgctccc acccggccag    420

ccccagcccg ccggggccgc aggccagccc ggtgctgcca gtcagctacc gcctgtcgca    480

cacgcggctg gccttcttcc tgcgggaggc gcggcccccg tcacccgcgg tcgccaacag    540

ctctctgcag cgctccgagc ccttcgtggt gttccagacc aaggagctgc cggtcctcaa    600

cgtctctctg gggcccttca gcaccagcca ggtggtggcg cgggagctcc tgcagccgtc    660

cagcaccctg gacatccccg agcgcctgac ggtgaactgg aaggtgcggg ccttcatcgt    720

ccgctcgcac gtgcccgcct cgcagcccgt ggtccaggtg ctgttctacg tagccggccg    780

ggactgggac gacttcggcg tcaccgagcg gctgccctgt gtccgcctgc atgccttccg    840

ggatgcccgg gaacaccccc tgctgcgcat cgggagcatc agcctgttcc gcccgccccc    900

caggaggacc ctgcaggagc acaggctgga cagcaacctg atgatccgcc tgccagaccg    960

gcccctcaag cccggggaag tgctcagcat cctcctctat ctggccccca actcctcctc   1020

gccctccagc cccagcgtgg agcacttcac actcagggtg aaggccaaga agggtgtgac   1080

ccttttaggt accaagtcac ggagtggcca gtggcatgtg acctcggagc tgctgactgg   1140

ggcaaagcac tcaacagcca ccgtggatgt ggcctgggct cagagcacac ccctgccccc   1200

cagggagggc cagggcccct tggagatctt gcagctggac tttgaaatgg agaacttcac   1260

cagccagtca gtcaagcgga ggatcatgtg gcacattgac taccgtggcc acggcgccct   1320

gcctgacctg gagcgggcag tcactgagct gacggtcatt cagcgggatg tgcaagccat   1380

cctgcccctg gccatggaca cagagatcat caacacggcc attctgactg gccggacagt   1440

ggccatccct gtcaaggtca ttgccatcga ggtgaatggc ctcgtcctgg acatctccgc   1500

cctagtggaa tgcgagtctg acaatgaaga catcatcaag gtatccagca gctgtgacta   1560

cgtgtttgtg agtggaaaag agtctcgagg gtccatgaac gccagggtca ccttccgcta   1620

cgacgtcctc aatgctcccc tggaaatgac agtctgggtc cccaagctgc ccttgcacat   1680

tgagctctca gatgcccgcc tcagccaagt gaagggctgg agggtaccta tcctccccga   1740

ccggaggtca gtccgggaaa gcgaggatga ggatgaggag gaggaggagc ggcggcagag   1800

tgcaagccgt ggctgcaccc tgcagtacca gcatgccacc ctgcaggtct tcacccagtt   1860

ccacacgaca tcatccgagg gcactgacca ggtggtcacc atgttaggcc cggactggct   1920

ggtggaggtc accgacctag tcagtgactt catgcgggtg ggcgatcccc gagtggcaca   1980

catggtggac agcagcacgc tggcaggact ggagccaggc accaccccct ttaaggtggt   2040

gtctccgctg acggaggctg tgctcgggga gacgctgctg acggtgactg aggagaaggt   2100

cagcatcaca cagcttcagg cccaggtggt ggccagcctg gccctctccc tgcggcccag   2160

ccctgggagc agccacacca tcctagccac cacagctgcc caacagacct tgagcttcct   2220

caagcaggaa gccctactga gcctctggct ctcctacagt gatggcacca cagccccact   2280

ctccctctac agcccacgag actatggact gctagtgagc agcctggatg agcatgtggc   2340

cactgtgacc caggaccggg ccttccctct ggtagtggct gaggccgagg ggtcagggga   2400

gctgcttcgc gcagagctaa ccatcgctga gagctgccag aaaaccaaac gcaagagtgt   2460

gctcgccacg acccctgtgg gcctgcgggt gcactttggg agggacgagg aggaccccac   2520

ttatgactac ccgggcccca gccaaccagg gcccggcggg ggcgaggacg aggcccgggg   2580

agctggcccg ccgggctctg cgctacccgc accggaggct ccaggcccgg gcaccgccag   2640

ccccgtcgtg ccacccacag aagacttcct gccgctgccc accggcttcc tgcaggtgcc   2700

acggggtctg acagacctgg agatcggcat gtacgcgctg ctgggcgtct tctgcctcgc   2760

catcctcgtc ttcctcatca actgcatcgt ttttgtgctg cgctaccggc acaagcgcat   2820

cccgcccgag ggccagacca gcatggacca ctctcaccac tgggtgttcc tgggcaacgg   2880

gcagccgctg cgggtgcaag gagagctgtc gccgccagca ggcaacccgc tggaaaccgt   2940

gcccgccttc tgccacggcg accaccacag cagcggcagc tcgcagacca gcgtccagag   3000

ccaggtgcac ggcaggggcg acggctcctc gggcggctca gcccgagacc aagccgagga   3060

ccccgccagc tcgcccacct ccaagcgcaa gcgggtcaag ttcaccacct tcaccacgct   3120

gccgtcagag gagctggcct atgactcggt gcccgcgggc gaagaggacg aggaggagga   3180

agaggacctg ggttggggct gcccggatgt ggcgggcccc acgcggccca ctgcaccccc   3240

ggacctgcac aattacatgc gcagaatcaa agagattgca tagaggcgcc agccggagta   3300

gcagggaccc ccccccacaa cggggtcagc tcggggtagg acacagccgg gaccccggtt   3360

cacactgact ctgggcggct gaattgattt tgtactccct gcccctgcag cttggctccg   3420

tgcggagcgg gccgcctcag tgtctgggcc ttccctcgcc tcacgccatt accctcttct   3480

gccccctgca ggtggagggc tcttcctcca gtggctcgta aggaggaaag caaccccagc   3540

ctctgttctg ccctttccaa acctcctccc atcttaagca accccctgcc ccaagagtga   3600

ggcaaggagg tccagcttgg ggtcaggtgg gcccacgctg tgtcccggcc ccgcctcccg   3660

tcccccgtgt cgtccccctg tgcagggggt tctgtggggg tcttgtgtca caggctgcac   3720

aaagactttc ctcaaactaa tattcaggga tttctgtcct gcagggtggg gaggtggcag   3780

ctgcctgccc tgccaaggat cttgctgtgg acgaaatatc tgggggttag ggggacagtt   3840

gtagcatctg ctggcattcg ggtgcctccc aggacctggg agctgactct acagagaggt   3900

ctggtgccaa gccaggcacc ttcctgagtt ctcaggactc ccacctctgc cccaagggct   3960

ttgggcaggg acctaaaggg gaaagagtcc tggatccatc tctagccaaa tcacacccca   4020

gagccagagg cctggggacc tccttgcctt ccccgtcccc cacagcaagg tcaacactac   4080

tacgccttag ccacccctca ccctgctgac tgcgacttcc ctctgcagca cagggcaggc   4140

agccacctat cccccacaag acggaacccg ggaggggagt agagggcacc agggaatgct   4200

gtgagggact tcagggtggg caaatgcaga agggagccag tgtcgcccct accccatccc   4260

acagccattt ttctctcggg ttctacccac cactgtgtcg gatttttctt aaataaatgg   4320

aagcggtcag actggaggtg ggggcagcag ctcccatgaa cagagagta               4369


<210>  497
<211>  984
<212>  PRT
<213>  Homo sapiens

<400>  497


Met Ala Pro Gly Met Ser Gly Arg Gly Gly Ala Ala Leu Leu Cys Leu 
1               5                   10                  15      


Ser Ala Leu Leu Ala His Ala Ser Gly Arg Ser His Pro Ala Ser Pro 
            20                  25                  30          


Ser Pro Pro Gly Pro Gln Ala Ser Pro Val Leu Pro Val Ser Tyr Arg 
        35                  40                  45              


Leu Ser His Thr Arg Leu Ala Phe Phe Leu Arg Glu Ala Arg Pro Pro 
    50                  55                  60                  


Ser Pro Ala Val Ala Asn Ser Ser Leu Gln Arg Ser Glu Pro Phe Val 
65                  70                  75                  80  


Val Phe Gln Thr Lys Glu Leu Pro Val Leu Asn Val Ser Leu Gly Pro 
                85                  90                  95      


Phe Ser Thr Ser Gln Val Val Ala Arg Glu Leu Leu Gln Pro Ser Ser 
            100                 105                 110         


Thr Leu Asp Ile Pro Glu Arg Leu Thr Val Asn Trp Lys Val Arg Ala 
        115                 120                 125             


Phe Ile Val Arg Ser His Val Pro Ala Ser Gln Pro Val Val Gln Val 
    130                 135                 140                 


Leu Phe Tyr Val Ala Gly Arg Asp Trp Asp Asp Phe Gly Val Thr Glu 
145                 150                 155                 160 


Arg Leu Pro Cys Val Arg Leu His Ala Phe Arg Asp Ala Arg Glu His 
                165                 170                 175     


Pro Leu Leu Arg Ile Gly Ser Ile Ser Leu Phe Arg Pro Pro Pro Arg 
            180                 185                 190         


Arg Thr Leu Gln Glu His Arg Leu Asp Ser Asn Leu Met Ile Arg Leu 
        195                 200                 205             


Pro Asp Arg Pro Leu Lys Pro Gly Glu Val Leu Ser Ile Leu Leu Tyr 
    210                 215                 220                 


Leu Ala Pro Asn Ser Ser Ser Pro Ser Ser Pro Ser Val Glu His Phe 
225                 230                 235                 240 


Thr Leu Arg Val Lys Ala Lys Lys Gly Val Thr Leu Leu Gly Thr Lys 
                245                 250                 255     


Ser Arg Ser Gly Gln Trp His Val Thr Ser Glu Leu Leu Thr Gly Ala 
            260                 265                 270         


Lys His Ser Thr Ala Thr Val Asp Val Ala Trp Ala Gln Ser Thr Pro 
        275                 280                 285             


Leu Pro Pro Arg Glu Gly Gln Gly Pro Leu Glu Ile Leu Gln Leu Asp 
    290                 295                 300                 


Phe Glu Met Glu Asn Phe Thr Ser Gln Ser Val Lys Arg Arg Ile Met 
305                 310                 315                 320 


Trp His Ile Asp Tyr Arg Gly His Gly Ala Leu Pro Asp Leu Glu Arg 
                325                 330                 335     


Ala Val Thr Glu Leu Thr Val Ile Gln Arg Asp Val Gln Ala Ile Leu 
            340                 345                 350         


Pro Leu Ala Met Asp Thr Glu Ile Ile Asn Thr Ala Ile Leu Thr Gly 
        355                 360                 365             


Arg Thr Val Ala Ile Pro Val Lys Val Ile Ala Ile Glu Val Asn Gly 
    370                 375                 380                 


Leu Val Leu Asp Ile Ser Ala Leu Val Glu Cys Glu Ser Asp Asn Glu 
385                 390                 395                 400 


Asp Ile Ile Lys Val Ser Ser Ser Cys Asp Tyr Val Phe Val Ser Gly 
                405                 410                 415     


Lys Glu Ser Arg Gly Ser Met Asn Ala Arg Val Thr Phe Arg Tyr Asp 
            420                 425                 430         


Val Leu Asn Ala Pro Leu Glu Met Thr Val Trp Val Pro Lys Leu Pro 
        435                 440                 445             


Leu His Ile Glu Leu Ser Asp Ala Arg Leu Ser Gln Val Lys Gly Trp 
    450                 455                 460                 


Arg Val Pro Ile Leu Pro Asp Arg Arg Ser Val Arg Glu Ser Glu Asp 
465                 470                 475                 480 


Glu Asp Glu Glu Glu Glu Glu Arg Arg Gln Ser Ala Ser Arg Gly Cys 
                485                 490                 495     


Thr Leu Gln Tyr Gln His Ala Thr Leu Gln Val Phe Thr Gln Phe His 
            500                 505                 510         


Thr Thr Ser Ser Glu Gly Thr Asp Gln Val Val Thr Met Leu Gly Pro 
        515                 520                 525             


Asp Trp Leu Val Glu Val Thr Asp Leu Val Ser Asp Phe Met Arg Val 
    530                 535                 540                 


Gly Asp Pro Arg Val Ala His Met Val Asp Ser Ser Thr Leu Ala Gly 
545                 550                 555                 560 


Leu Glu Pro Gly Thr Thr Pro Phe Lys Val Val Ser Pro Leu Thr Glu 
                565                 570                 575     


Ala Val Leu Gly Glu Thr Leu Leu Thr Val Thr Glu Glu Lys Val Ser 
            580                 585                 590         


Ile Thr Gln Leu Gln Ala Gln Val Val Ala Ser Leu Ala Leu Ser Leu 
        595                 600                 605             


Arg Pro Ser Pro Gly Ser Ser His Thr Ile Leu Ala Thr Thr Ala Ala 
    610                 615                 620                 


Gln Gln Thr Leu Ser Phe Leu Lys Gln Glu Ala Leu Leu Ser Leu Trp 
625                 630                 635                 640 


Leu Ser Tyr Ser Asp Gly Thr Thr Ala Pro Leu Ser Leu Tyr Ser Pro 
                645                 650                 655     


Arg Asp Tyr Gly Leu Leu Val Ser Ser Leu Asp Glu His Val Ala Thr 
            660                 665                 670         


Val Thr Gln Asp Arg Ala Phe Pro Leu Val Val Ala Glu Ala Glu Gly 
        675                 680                 685             


Ser Gly Glu Leu Leu Arg Ala Glu Leu Thr Ile Ala Glu Ser Cys Gln 
    690                 695                 700                 


Lys Thr Lys Arg Lys Ser Val Leu Ala Thr Thr Pro Val Gly Leu Arg 
705                 710                 715                 720 


Val His Phe Gly Arg Asp Glu Glu Asp Pro Thr Tyr Asp Tyr Pro Gly 
                725                 730                 735     


Pro Ser Gln Pro Gly Pro Gly Gly Gly Glu Asp Glu Ala Arg Gly Ala 
            740                 745                 750         


Gly Pro Pro Gly Ser Ala Leu Pro Ala Pro Glu Ala Pro Gly Pro Gly 
        755                 760                 765             


Thr Ala Ser Pro Val Val Pro Pro Thr Glu Asp Phe Leu Pro Leu Pro 
    770                 775                 780                 


Thr Gly Phe Leu Gln Val Pro Arg Gly Leu Thr Asp Leu Glu Ile Gly 
785                 790                 795                 800 


Met Tyr Ala Leu Leu Gly Val Phe Cys Leu Ala Ile Leu Val Phe Leu 
                805                 810                 815     


Ile Asn Cys Ile Val Phe Val Leu Arg Tyr Arg His Lys Arg Ile Pro 
            820                 825                 830         


Pro Glu Gly Gln Thr Ser Met Asp His Ser His His Trp Val Phe Leu 
        835                 840                 845             


Gly Asn Gly Gln Pro Leu Arg Val Gln Gly Glu Leu Ser Pro Pro Ala 
    850                 855                 860                 


Gly Asn Pro Leu Glu Thr Val Pro Ala Phe Cys His Gly Asp His His 
865                 870                 875                 880 


Ser Ser Gly Ser Ser Gln Thr Ser Val Gln Ser Gln Val His Gly Arg 
                885                 890                 895     


Gly Asp Gly Ser Ser Gly Gly Ser Ala Arg Asp Gln Ala Glu Asp Pro 
            900                 905                 910         


Ala Ser Ser Pro Thr Ser Lys Arg Lys Arg Val Lys Phe Thr Thr Phe 
        915                 920                 925             


Thr Thr Leu Pro Ser Glu Glu Leu Ala Tyr Asp Ser Val Pro Ala Gly 
    930                 935                 940                 


Glu Glu Asp Glu Glu Glu Glu Glu Asp Leu Gly Trp Gly Cys Pro Asp 
945                 950                 955                 960 


Val Ala Gly Pro Thr Arg Pro Thr Ala Pro Pro Asp Leu His Asn Tyr 
                965                 970                 975     


Met Arg Arg Ile Lys Glu Ile Ala 
            980                 

<210>  498
<211>  3134
<212>  DNA
<213>  Homo sapiens

<400>  498
agagcggcgc gcgcggcagc cccgaggcag cagagcgcgg agccgggagc gcggggagcg     60

cgggccggcg gcggcgaggg aggacggggg cgcagacggc cggcgcgcgg cgcggctacc    120

atgggcgtgc ggtgagcagc cgctcgggac gacttcctcg gctgcgcggc gctcgcgcgg    180

agctccccgg ccggcggtgc gtccccacgg tcaccatgaa agacgacttc gcagaggagg    240

aggaggtgca atccttcggt tacaagcggt ttggtattca ggaaggaaca caatgtacca    300

aatgtaaaaa taactgggca ctgaagtttt ctatcatatt attatacatt ttgtgtgcct    360

tgctaacaat cacagtagcc attttgggat ataaagttgt agagaaaatg gacaatgtca    420

caggtggcat ggaaacatct cgccaaacct atgatgacaa gctcacagca gtggaaagtg    480

acctgaaaaa attaggtgac caaactggga agaaagctat cagcaccaac tcagaactct    540

ccaccttcag atcagacatt ctagatctcc gtcagcaact tcgtgagatt acagaaaaaa    600

ccagcaagaa caaggatacg ctggagaagt tacaggcgag cggggatgct ctggtggaca    660

ggcagagtca attgaaagaa actttggaga ataactcttt cctcatcacc actgtaaaca    720

aaaccctcca ggcgtataat ggctatgtca cgaatctgca gcaagatacc agcgtgctcc    780

agggcaatct gcagaaccaa atgtattctc ataatgtggt catcatgaac ctcaacaacc    840

tgaacctgac ccaggtgcag cagaggaacc tcatcacgaa tctgcagcgg tctgtggatg    900

acacaagcca ggctatccag cgaatcaaga acgactttca aaatctgcag caggtttttc    960

ttcaagccaa gaaggacacg gattggctga aggagaaagt gcagagcttg cagacgctgg   1020

ctgccaacaa ctctgcgttg gccaaagcca acaacgacac cctggaggat atgaacagcc   1080

agctcaactc attcacaggt cagatggaga acatcaccac tatctctcaa gccaacgagc   1140

agaacctgaa agacctgcag gacttacaca aagatgcaga gaatagaaca gccatcaagt   1200

tcaaccaact ggaggaacgc ttccagctct ttgagacgga tattgtgaac atcattagca   1260

atatcagtta cacagcccac cacctgcgga cgctgaccag caatctaaat gaagtcagga   1320

ccacttgcac agataccctt accaaacaca cagatgatct gacctccttg aataataccc   1380

tggccaacat ccgtttggat tctgtttctc tcaggatgca acaagatttg atgaggtcga   1440

ggttagacac tgaagtagcc aacttatcag tgattatgga agaaatgaag ctagtagact   1500

ccaagcatgg tcagctcatc aagaatttta caatactaca aggtccaccg ggccccaggg   1560

gtccaagagg tgacagagga tcccagggac cccctggccc aactggcaac aagggacaga   1620

aaggagagaa gggggagcct ggaccacctg gccctgcggg tgagagaggc ccaattggac   1680

cagctggtcc ccccggagag cgtggcggca aaggatctaa aggctcccag ggccccaaag   1740

gctcccgtgg ttcccctggg aagcccggcc ctcagggccc cagtggggac ccaggccccc   1800

cgggcccacc aggcaaagag ggactccccg gccctcaggg ccctcctggc ttccagggac   1860

ttcagggcac cgttggggag cctggggtgc ctggacctcg gggactgcca ggcttgcctg   1920

gggtaccagg catgccaggc cccaagggcc cccccggccc tcctggccca tcaggagcgg   1980

tggtgcccct ggccctgcag aatgagccaa ccccggcacc ggaggacaat ggctgcccgc   2040

ctcactggaa gaacttcaca gacaaatgct actatttttc agttgagaaa gaaatttttg   2100

aggatgcaaa gcttttctgt gaagacaagt cttcacatct tgttttcata aacactagag   2160

aggaacagca atggataaaa aaacagatgg tagggagaga gagccactgg atcggcctca   2220

cagactcaga gcgtgaaaat gaatggaagt ggctggatgg gacatctcca gactacaaaa   2280

attggaaagc tggacagccg gataactggg gtcatggcca tgggccagga gaagactgtg   2340

ctgggttgat ttatgctggg cagtggaacg atttccaatg tgaagacgtc aataacttca   2400

tttgcgaaaa agacagggag acagtactgt catctgcatt ataacggact gtgatgggat   2460

cacatgagca aattttcagc tctcaaaggc aaaggacact cctttctaat tgcatcacct   2520

tctcatcaga ttgaaaaaaa aaaagcactg aaaaccaatt actgaaaaaa aattgacagc   2580

tagtgttttt taccatccgt cattacccaa agacttggga actaaaatgt tccccagggt   2640

gatatgctga ttttcattgt gcacatggac tgaatcacat agattctcct ccgtcagtaa   2700

ccgtgcgatt atacaaatta tgtcttccaa agtatggaac actccaatca gaaaaaggtt   2760

atcattggtc gttgagttat gggaagaact taagcatata ctgtgtaaac agtgccatac   2820

atttctaaaa tcccaagtgt aggaaaaata tgcagacata cagatatata ggccaactat   2880

tagtaataat atgaaatata cttaaagagc ttttaaaact ttgtattttt gtacaaaata   2940

tttgtctttt acaatttttt tccttttttt ttttttgtca ttttaccgac ataatacatg   3000

gagccaaaga aaacaataat ggtactaata aaaactccta gggtttcctg tcagatttaa   3060

ttctacccag tggcaaagaa ttttttcaat tgtggcttta aaaaaataat taaatataca   3120

tgtgtatata tata                                                     3134


<210>  499
<211>  742
<212>  PRT
<213>  Homo sapiens

<400>  499


Met Lys Asp Asp Phe Ala Glu Glu Glu Glu Val Gln Ser Phe Gly Tyr 
1               5                   10                  15      


Lys Arg Phe Gly Ile Gln Glu Gly Thr Gln Cys Thr Lys Cys Lys Asn 
            20                  25                  30          


Asn Trp Ala Leu Lys Phe Ser Ile Ile Leu Leu Tyr Ile Leu Cys Ala 
        35                  40                  45              


Leu Leu Thr Ile Thr Val Ala Ile Leu Gly Tyr Lys Val Val Glu Lys 
    50                  55                  60                  


Met Asp Asn Val Thr Gly Gly Met Glu Thr Ser Arg Gln Thr Tyr Asp 
65                  70                  75                  80  


Asp Lys Leu Thr Ala Val Glu Ser Asp Leu Lys Lys Leu Gly Asp Gln 
                85                  90                  95      


Thr Gly Lys Lys Ala Ile Ser Thr Asn Ser Glu Leu Ser Thr Phe Arg 
            100                 105                 110         


Ser Asp Ile Leu Asp Leu Arg Gln Gln Leu Arg Glu Ile Thr Glu Lys 
        115                 120                 125             


Thr Ser Lys Asn Lys Asp Thr Leu Glu Lys Leu Gln Ala Ser Gly Asp 
    130                 135                 140                 


Ala Leu Val Asp Arg Gln Ser Gln Leu Lys Glu Thr Leu Glu Asn Asn 
145                 150                 155                 160 


Ser Phe Leu Ile Thr Thr Val Asn Lys Thr Leu Gln Ala Tyr Asn Gly 
                165                 170                 175     


Tyr Val Thr Asn Leu Gln Gln Asp Thr Ser Val Leu Gln Gly Asn Leu 
            180                 185                 190         


Gln Asn Gln Met Tyr Ser His Asn Val Val Ile Met Asn Leu Asn Asn 
        195                 200                 205             


Leu Asn Leu Thr Gln Val Gln Gln Arg Asn Leu Ile Thr Asn Leu Gln 
    210                 215                 220                 


Arg Ser Val Asp Asp Thr Ser Gln Ala Ile Gln Arg Ile Lys Asn Asp 
225                 230                 235                 240 


Phe Gln Asn Leu Gln Gln Val Phe Leu Gln Ala Lys Lys Asp Thr Asp 
                245                 250                 255     


Trp Leu Lys Glu Lys Val Gln Ser Leu Gln Thr Leu Ala Ala Asn Asn 
            260                 265                 270         


Ser Ala Leu Ala Lys Ala Asn Asn Asp Thr Leu Glu Asp Met Asn Ser 
        275                 280                 285             


Gln Leu Asn Ser Phe Thr Gly Gln Met Glu Asn Ile Thr Thr Ile Ser 
    290                 295                 300                 


Gln Ala Asn Glu Gln Asn Leu Lys Asp Leu Gln Asp Leu His Lys Asp 
305                 310                 315                 320 


Ala Glu Asn Arg Thr Ala Ile Lys Phe Asn Gln Leu Glu Glu Arg Phe 
                325                 330                 335     


Gln Leu Phe Glu Thr Asp Ile Val Asn Ile Ile Ser Asn Ile Ser Tyr 
            340                 345                 350         


Thr Ala His His Leu Arg Thr Leu Thr Ser Asn Leu Asn Glu Val Arg 
        355                 360                 365             


Thr Thr Cys Thr Asp Thr Leu Thr Lys His Thr Asp Asp Leu Thr Ser 
    370                 375                 380                 


Leu Asn Asn Thr Leu Ala Asn Ile Arg Leu Asp Ser Val Ser Leu Arg 
385                 390                 395                 400 


Met Gln Gln Asp Leu Met Arg Ser Arg Leu Asp Thr Glu Val Ala Asn 
                405                 410                 415     


Leu Ser Val Ile Met Glu Glu Met Lys Leu Val Asp Ser Lys His Gly 
            420                 425                 430         


Gln Leu Ile Lys Asn Phe Thr Ile Leu Gln Gly Pro Pro Gly Pro Arg 
        435                 440                 445             


Gly Pro Arg Gly Asp Arg Gly Ser Gln Gly Pro Pro Gly Pro Thr Gly 
    450                 455                 460                 


Asn Lys Gly Gln Lys Gly Glu Lys Gly Glu Pro Gly Pro Pro Gly Pro 
465                 470                 475                 480 


Ala Gly Glu Arg Gly Pro Ile Gly Pro Ala Gly Pro Pro Gly Glu Arg 
                485                 490                 495     


Gly Gly Lys Gly Ser Lys Gly Ser Gln Gly Pro Lys Gly Ser Arg Gly 
            500                 505                 510         


Ser Pro Gly Lys Pro Gly Pro Gln Gly Pro Ser Gly Asp Pro Gly Pro 
        515                 520                 525             


Pro Gly Pro Pro Gly Lys Glu Gly Leu Pro Gly Pro Gln Gly Pro Pro 
    530                 535                 540                 


Gly Phe Gln Gly Leu Gln Gly Thr Val Gly Glu Pro Gly Val Pro Gly 
545                 550                 555                 560 


Pro Arg Gly Leu Pro Gly Leu Pro Gly Val Pro Gly Met Pro Gly Pro 
                565                 570                 575     


Lys Gly Pro Pro Gly Pro Pro Gly Pro Ser Gly Ala Val Val Pro Leu 
            580                 585                 590         


Ala Leu Gln Asn Glu Pro Thr Pro Ala Pro Glu Asp Asn Gly Cys Pro 
        595                 600                 605             


Pro His Trp Lys Asn Phe Thr Asp Lys Cys Tyr Tyr Phe Ser Val Glu 
    610                 615                 620                 


Lys Glu Ile Phe Glu Asp Ala Lys Leu Phe Cys Glu Asp Lys Ser Ser 
625                 630                 635                 640 


His Leu Val Phe Ile Asn Thr Arg Glu Glu Gln Gln Trp Ile Lys Lys 
                645                 650                 655     


Gln Met Val Gly Arg Glu Ser His Trp Ile Gly Leu Thr Asp Ser Glu 
            660                 665                 670         


Arg Glu Asn Glu Trp Lys Trp Leu Asp Gly Thr Ser Pro Asp Tyr Lys 
        675                 680                 685             


Asn Trp Lys Ala Gly Gln Pro Asp Asn Trp Gly His Gly His Gly Pro 
    690                 695                 700                 


Gly Glu Asp Cys Ala Gly Leu Ile Tyr Ala Gly Gln Trp Asn Asp Phe 
705                 710                 715                 720 


Gln Cys Glu Asp Val Asn Asn Phe Ile Cys Glu Lys Asp Arg Glu Thr 
                725                 730                 735     


Val Leu Ser Ser Ala Leu 
            740         

<210>  500
<211>  1141
<212>  DNA
<213>  Homo sapiens

<400>  500
ccacactcag tctggcctcg gggcctttgc actggctgtg tcccctgcct gtgatgccat     60

tctcctctgc ctggccaact cctacgttta ttcaagtctg gaccttgtca tcggctcctc    120

aggaaggcac tccgggaccc ccagatgggg gcggttccct gtgactcctg gcacggaggc    180

caaccccttc cttgttcaat ggttccttga gggaccattc ccatgtgatt atcgaccatt    240

cggcaggcgt tcaaagtcaa aggccccaca ctgagtcctg gcccagcgcc ctgtgcccgt    300

tggctgctgg agggacagac ggggcgtgcg gctgaccatc ccgtgcccgc aggctgagga    360

tgcagcgctg gaaggcggcg gccttggcct cagtgctctg cagctccgtg ctgtccatct    420

ggatgtgtcg agagggcctg cttctcagcc accgcctcgg acctgcgctg gtccccctgc    480

accgcctgcc tcgaaccctg gacgcccgga ttgcccgcct ggcccagtac cgtgcactcc    540

tgcagggggc cccggatgcg atggagctgc gcgagctgac gccctgggct gggcggcccc    600

caggtccgcg ccgtcgggcg gggccccggc ggcggcgcgc gcgtgcgcgg ttgggggcgc    660

ggccttgcgg gctgcgcgag ctggaggtgc gcgtgagcga gctgggcctg ggctacgcgt    720

ccgacgagac ggtgctgttc cgctactgcg caggcgcctg cgaggctgcc gcgcgcgtct    780

acgacctcgg gctgcgacga ctgcgccagc ggcggcgcct gcggcgggag cgggtgcgcg    840

cgcagccctg ctgccgcccg acggcctacg aggacgaggt gtccttcctg gacgcgcaca    900

gccgctacca cacggtgcac gagctgtcgg cgcgcgagtg cgcctgcgtg tgaccctacc    960

tcactcggcc ggcgcggcgg ccactccccc cgcctcgacg gcaccactgg ccggccccgc   1020

gaaagactgc gcgtgcgtag agcacgccgg cgcggccccg ggactctcgc gataactgta   1080

ctgagataaa gtgtggcaac tcgaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   1140

a                                                                   1141


<210>  501
<211>  197
<212>  PRT
<213>  Homo sapiens

<400>  501


Met Gln Arg Trp Lys Ala Ala Ala Leu Ala Ser Val Leu Cys Ser Ser 
1               5                   10                  15      


Val Leu Ser Ile Trp Met Cys Arg Glu Gly Leu Leu Leu Ser His Arg 
            20                  25                  30          


Leu Gly Pro Ala Leu Val Pro Leu His Arg Leu Pro Arg Thr Leu Asp 
        35                  40                  45              


Ala Arg Ile Ala Arg Leu Ala Gln Tyr Arg Ala Leu Leu Gln Gly Ala 
    50                  55                  60                  


Pro Asp Ala Met Glu Leu Arg Glu Leu Thr Pro Trp Ala Gly Arg Pro 
65                  70                  75                  80  


Pro Gly Pro Arg Arg Arg Ala Gly Pro Arg Arg Arg Arg Ala Arg Ala 
                85                  90                  95      


Arg Leu Gly Ala Arg Pro Cys Gly Leu Arg Glu Leu Glu Val Arg Val 
            100                 105                 110         


Ser Glu Leu Gly Leu Gly Tyr Ala Ser Asp Glu Thr Val Leu Phe Arg 
        115                 120                 125             


Tyr Cys Ala Gly Ala Cys Glu Ala Ala Ala Arg Val Tyr Asp Leu Gly 
    130                 135                 140                 


Leu Arg Arg Leu Arg Gln Arg Arg Arg Leu Arg Arg Glu Arg Val Arg 
145                 150                 155                 160 


Ala Gln Pro Cys Cys Arg Pro Thr Ala Tyr Glu Asp Glu Val Ser Phe 
                165                 170                 175     


Leu Asp Ala His Ser Arg Tyr His Thr Val His Glu Leu Ser Ala Arg 
            180                 185                 190         


Glu Cys Ala Cys Val 
        195         

<210>  502
<211>  3137
<212>  DNA
<213>  Homo sapiens

<400>  502
aaaaccagta ttccagatca tttctctcca ttccaggaag tttgcatagc tccctggact     60

tctgctttgc actgccctgc aggagtgggt ggggaaagga agtggctttg aggcacacag    120

aggggcttgt tgaggccacc ggaggaagct tctgccacca atatgggacc tgtgcccagc    180

ctaccagaag agagcatctg aaaacatgta tcgacatggt aacccctctg cttgaagcct    240

cacatggctc cctattgcct tggtgctgaa caccctatgg ctgaccgtgg cccagcctct    300

gcaacagctc tgcctcctct ccagtggtga agacccagcc tgctgagact cctcctgcag    360

ttcctcaaca tgcctgcatt tctgctgcct cagggccttt gcgaaggttg ttccttgtaa    420

ctggaatgcc cttccatccc ttttttattc aaaaggctgc aattttaatt gaagaaagtt    480

cccttccaag gttcatgagt tgcctgactt gcccaccggt ttcctgcaag atcccttggc    540

ctggcactta gtgctcagga aatatttggt gatgggccaa ctgagtgaga aggtgggatc    600

tggtgggaag gaaagcggaa aggtagaaat tctgctcact tcctcattcc cacctcccaa    660

ggaacccctg gtgtccctgt ggaacccgct ttgggaaccg gtggttcagg tcagcctttt    720

cactttgtac tcaaagccac atcgcattga agccacaggt ggggcaaggt catgcatgac    780

ctgagtctcc aaatcccttc accctgtttg gttctgcaac ggggattagg ggagccccac    840

gatttgtttt caaaggatgt ccgggctcca ggacaggatg ccctgggtca cctgatgaca    900

ggtgtggtgg ttggaaaggg cctggtttca gctccgggta cacttcctcc ttccttctgc    960

tgcgtggtgt ggcctcttcc acgtcctcag aatccagctg ttactccgtc cgcggcctct   1020

cagctctagg gccctctgca cactggcccc cccagtgtca cgggcatcca gacgggatcc   1080

agtgcatcct cttttagaag aaaggcctgt ctccagatcc ccgagtccct ctagcatctc   1140

ccagaaggtg tcagacgcag cagtgtccag ggagcggcag cagatactct gacccatgga   1200

tcccctgggc ccggccaagc cacagtggtc gtggcgctgc tgtctgacca cgctgctgtt   1260

tcagctgctg atggctgtgt gtttcttctc ctatctgcgt gtgtctcaag acgatcccac   1320

tgtgtaccct aatgggtccc gcttcccaga cagcacaggg acccccgccc actccatccc   1380

cctgatcctg ctgtggacgt ggccttttaa caaacccata gctctgcccc gctgctcaga   1440

gatggtgcct ggcacggctg actgcaacat cactgccgac cgcaaggtgt atccacaggc   1500

agacgcggtc atcgtgcacc accgagaggt catgtacaac cccagtgccc agctcccacg   1560

ctccccgagg cggcaggggc agcgatggat ctggttcagc atggagtccc caagccactg   1620

ctggcagctg aaagccatgg acggatactt caatctcacc atgtcctacc gcagcgactc   1680

cgacatcttc acgccctacg gctggctgga gccgtggtcc ggccagcctg cccacccacc   1740

gctcaacctc tcggccaaga ccgagctggt ggcctgggca gtgtccaact gggggccaaa   1800

ctccgccagg gtgcgctact accagagcct gcaggcccat ctcaaggtgg acgtgtacgg   1860

acgctcccac aagcccctgc cccagggaac catgatggag acgctgtccc ggtacaagtt   1920

ctatctggcc ttcgagaact ccttgcaccc cgactacatc accgagaagc tgtggaggaa   1980

cgccctggag gcctgggccg tgcccgtggt gctgggcccc agcagaagca actacgagag   2040

gttcctgcca cccgacgcct tcatccacgt ggacgacttc cagagcccca aggacctggc   2100

ccggtacctg caggagctgg acaaggacca cgcccgctac ctgagctact ttcgctggcg   2160

ggagacgctg cggcctcgct ccttcagctg ggcactcgct ttctgcaagg cctgctggaa   2220

actgcaggag gaatccaggt accagacacg cggcatagcg gcttggttca cctgagaggc   2280

tggtgtgggg cctgggctgc caggaacctc attttcctgg ggcctcacct gagtgggggc   2340

ctcatctacc taaggactcg tttgcctgaa gcttcacctg cctgaggact cacctgcctg   2400

ggacggtcac ctgttgcagc ttcacctgcc tggggattca cctacctggg tcctcacttt   2460

cctggggcct cacctgctgg agtcttcggt ggccaggtat gtcccttacc tgggatttca   2520

catgctggct tccaggagcg tcccctgcgg aagcctggcc tgctggggat gtctcctggg   2580

gactttgcct actggggacc tcggctgttg gggactttac ctgctgggac ctgctcccag   2640

agaccttcca cactgaatct cacctgctag gagcctcacc tgctggggac ctcaccctgg   2700

agggcactgg gccctgggaa ctggcaccca tggggcccca cccatgagtg atggttctgg   2760

ctgatttgtt tgtgatgttg ttagccgcct gtgaggggtg cagagagata atcaccgcac   2820

cgtttccaga tgtaatactg caaagaaaac cgatgatgag gccgggtgcg gtggctcaca   2880

cctgtaatcc cagcactttg ggaggccgag gcaggcggat cacaaggtca ggagatcgag   2940

accatcctgg ccaatatggt gaaacccgtc tctactaaaa atacaaaaat ttgccgggcg   3000

tggtggtgca tgcctgtaat cccagctact tgggaagctg aggcaggaga atcgcttgaa   3060

ccagagagtc ggaggttgca gtaagccgag atcgcgccac tgcactccag cctggcgaca   3120

gagcgagact ctgtctc                                                  3137


<210>  503
<211>  359
<212>  PRT
<213>  Homo sapiens

<400>  503


Met Asp Pro Leu Gly Pro Ala Lys Pro Gln Trp Ser Trp Arg Cys Cys 
1               5                   10                  15      


Leu Thr Thr Leu Leu Phe Gln Leu Leu Met Ala Val Cys Phe Phe Ser 
            20                  25                  30          


Tyr Leu Arg Val Ser Gln Asp Asp Pro Thr Val Tyr Pro Asn Gly Ser 
        35                  40                  45              


Arg Phe Pro Asp Ser Thr Gly Thr Pro Ala His Ser Ile Pro Leu Ile 
    50                  55                  60                  


Leu Leu Trp Thr Trp Pro Phe Asn Lys Pro Ile Ala Leu Pro Arg Cys 
65                  70                  75                  80  


Ser Glu Met Val Pro Gly Thr Ala Asp Cys Asn Ile Thr Ala Asp Arg 
                85                  90                  95      


Lys Val Tyr Pro Gln Ala Asp Ala Val Ile Val His His Arg Glu Val 
            100                 105                 110         


Met Tyr Asn Pro Ser Ala Gln Leu Pro Arg Ser Pro Arg Arg Gln Gly 
        115                 120                 125             


Gln Arg Trp Ile Trp Phe Ser Met Glu Ser Pro Ser His Cys Trp Gln 
    130                 135                 140                 


Leu Lys Ala Met Asp Gly Tyr Phe Asn Leu Thr Met Ser Tyr Arg Ser 
145                 150                 155                 160 


Asp Ser Asp Ile Phe Thr Pro Tyr Gly Trp Leu Glu Pro Trp Ser Gly 
                165                 170                 175     


Gln Pro Ala His Pro Pro Leu Asn Leu Ser Ala Lys Thr Glu Leu Val 
            180                 185                 190         


Ala Trp Ala Val Ser Asn Trp Gly Pro Asn Ser Ala Arg Val Arg Tyr 
        195                 200                 205             


Tyr Gln Ser Leu Gln Ala His Leu Lys Val Asp Val Tyr Gly Arg Ser 
    210                 215                 220                 


His Lys Pro Leu Pro Gln Gly Thr Met Met Glu Thr Leu Ser Arg Tyr 
225                 230                 235                 240 


Lys Phe Tyr Leu Ala Phe Glu Asn Ser Leu His Pro Asp Tyr Ile Thr 
                245                 250                 255     


Glu Lys Leu Trp Arg Asn Ala Leu Glu Ala Trp Ala Val Pro Val Val 
            260                 265                 270         


Leu Gly Pro Ser Arg Ser Asn Tyr Glu Arg Phe Leu Pro Pro Asp Ala 
        275                 280                 285             


Phe Ile His Val Asp Asp Phe Gln Ser Pro Lys Asp Leu Ala Arg Tyr 
    290                 295                 300                 


Leu Gln Glu Leu Asp Lys Asp His Ala Arg Tyr Leu Ser Tyr Phe Arg 
305                 310                 315                 320 


Trp Arg Glu Thr Leu Arg Pro Arg Ser Phe Ser Trp Ala Leu Ala Phe 
                325                 330                 335     


Cys Lys Ala Cys Trp Lys Leu Gln Glu Glu Ser Arg Tyr Gln Thr Arg 
            340                 345                 350         


Gly Ile Ala Ala Trp Phe Thr 
        355                 

<210>  504
<211>  3009
<212>  DNA
<213>  Homo sapiens

<400>  504
aaaaccagta ttccagatca tttctctcca ttccaggaag tttgcatagc tccctggact     60

tctgctttgc actgccctgc aggagtgggt ggggaaagga agtggctttg aggcacacag    120

aggggcttgt tgaggccacc ggaggaagct tctgccacca atatgggacc tgtgcccagc    180

ctaccagaag agagcatctg aaaacatgta tcgacatggt aacccctctg cttgaagcct    240

cacatggctc cctattgcct tggtgctgaa caccctatgg ctgaccgtgg cccagcctct    300

gcaacagctc tgcctcctct ccagtggtga agacccagcc tgctgagact cctcctgcag    360

ttcctcaaca tgcctgcatt tctgctgcct cagggccttt gcgaaggttg ttccttgtaa    420

ctggaatgcc cttccatccc ttttttattc aaaaggctgc aattttaatt gaagaaagtt    480

cccttccaag gttcatgagt tgcctgactt gcccaccggt ttcctgcaag atcccttggc    540

ctggcactta gtgctcagga aatatttggt gatgggccaa ctgagtgaga aggtgggatc    600

tggtgggaag gaaagcggaa aggtagaaat tctgctcact tcctcattcc cacctcccaa    660

ggaacccctg gtgtccctgt ggaacccgct ttgggaaccg gtggttcagg tcagcctttt    720

cactttgtac tcaaagccac atcgcattga agccacaggt ggggcaaggt catgcatgac    780

ctgagtctcc aaatcccttc accctgtttg gttctgcaac ggggattagg ggagccccac    840

gatttgtttt caaaggatgt ccgggctcca ggacaggatg ccctgggtca cctgatgaca    900

ggtgtggtgg ttggaaaggg cctggtttca gctccgggta cacttcctcc ttccttctgc    960

tgcgtggtgt ggcctcttcc acgtcctcag aatccagctg ttactccgtc cgcggcctct   1020

cagctctagg gccctctgca cactggcccc cccagatact ctgacccatg gatcccctgg   1080

gcccggccaa gccacagtgg tcgtggcgct gctgtctgac cacgctgctg tttcagctgc   1140

tgatggctgt gtgtttcttc tcctatctgc gtgtgtctca agacgatccc actgtgtacc   1200

ctaatgggtc ccgcttccca gacagcacag ggacccccgc ccactccatc cccctgatcc   1260

tgctgtggac gtggcctttt aacaaaccca tagctctgcc ccgctgctca gagatggtgc   1320

ctggcacggc tgactgcaac atcactgccg accgcaaggt gtatccacag gcagacgcgg   1380

tcatcgtgca ccaccgagag gtcatgtaca accccagtgc ccagctccca cgctccccga   1440

ggcggcaggg gcagcgatgg atctggttca gcatggagtc cccaagccac tgctggcagc   1500

tgaaagccat ggacggatac ttcaatctca ccatgtccta ccgcagcgac tccgacatct   1560

tcacgcccta cggctggctg gagccgtggt ccggccagcc tgcccaccca ccgctcaacc   1620

tctcggccaa gaccgagctg gtggcctggg cagtgtccaa ctgggggcca aactccgcca   1680

gggtgcgcta ctaccagagc ctgcaggccc atctcaaggt ggacgtgtac ggacgctccc   1740

acaagcccct gccccaggga accatgatgg agacgctgtc ccggtacaag ttctatctgg   1800

ccttcgagaa ctccttgcac cccgactaca tcaccgagaa gctgtggagg aacgccctgg   1860

aggcctgggc cgtgcccgtg gtgctgggcc ccagcagaag caactacgag aggttcctgc   1920

cacccgacgc cttcatccac gtggacgact tccagagccc caaggacctg gcccggtacc   1980

tgcaggagct ggacaaggac cacgcccgct acctgagcta ctttcgctgg cgggagacgc   2040

tgcggcctcg ctccttcagc tgggcactcg ctttctgcaa ggcctgctgg aaactgcagg   2100

aggaatccag gtaccagaca cgcggcatag cggcttggtt cacctgagag gctggtgtgg   2160

ggcctgggct gccaggaacc tcattttcct ggggcctcac ctgagtgggg gcctcatcta   2220

cctaaggact cgtttgcctg aagcttcacc tgcctgagga ctcacctgcc tgggacggtc   2280

acctgttgca gcttcacctg cctggggatt cacctacctg ggtcctcact ttcctggggc   2340

ctcacctgct ggagtcttcg gtggccaggt atgtccctta cctgggattt cacatgctgg   2400

cttccaggag cgtcccctgc ggaagcctgg cctgctgggg atgtctcctg gggactttgc   2460

ctactgggga cctcggctgt tggggacttt acctgctggg acctgctccc agagaccttc   2520

cacactgaat ctcacctgct aggagcctca cctgctgggg acctcaccct ggagggcact   2580

gggccctggg aactggcacc catggggccc cacccatgag tgatggttct ggctgatttg   2640

tttgtgatgt tgttagccgc ctgtgagggg tgcagagaga taatcaccgc accgtttcca   2700

gatgtaatac tgcaaagaaa accgatgatg aggccgggtg cggtggctca cacctgtaat   2760

cccagcactt tgggaggccg aggcaggcgg atcacaaggt caggagatcg agaccatcct   2820

ggccaatatg gtgaaacccg tctctactaa aaatacaaaa atttgccggg cgtggtggtg   2880

catgcctgta atcccagcta cttgggaagc tgaggcagga gaatcgcttg aaccagagag   2940

tcggaggttg cagtaagccg agatcgcgcc actgcactcc agcctggcga cagagcgaga   3000

ctctgtctc                                                           3009


<210>  505
<211>  359
<212>  PRT
<213>  Homo sapiens

<400>  505


Met Asp Pro Leu Gly Pro Ala Lys Pro Gln Trp Ser Trp Arg Cys Cys 
1               5                   10                  15      


Leu Thr Thr Leu Leu Phe Gln Leu Leu Met Ala Val Cys Phe Phe Ser 
            20                  25                  30          


Tyr Leu Arg Val Ser Gln Asp Asp Pro Thr Val Tyr Pro Asn Gly Ser 
        35                  40                  45              


Arg Phe Pro Asp Ser Thr Gly Thr Pro Ala His Ser Ile Pro Leu Ile 
    50                  55                  60                  


Leu Leu Trp Thr Trp Pro Phe Asn Lys Pro Ile Ala Leu Pro Arg Cys 
65                  70                  75                  80  


Ser Glu Met Val Pro Gly Thr Ala Asp Cys Asn Ile Thr Ala Asp Arg 
                85                  90                  95      


Lys Val Tyr Pro Gln Ala Asp Ala Val Ile Val His His Arg Glu Val 
            100                 105                 110         


Met Tyr Asn Pro Ser Ala Gln Leu Pro Arg Ser Pro Arg Arg Gln Gly 
        115                 120                 125             


Gln Arg Trp Ile Trp Phe Ser Met Glu Ser Pro Ser His Cys Trp Gln 
    130                 135                 140                 


Leu Lys Ala Met Asp Gly Tyr Phe Asn Leu Thr Met Ser Tyr Arg Ser 
145                 150                 155                 160 


Asp Ser Asp Ile Phe Thr Pro Tyr Gly Trp Leu Glu Pro Trp Ser Gly 
                165                 170                 175     


Gln Pro Ala His Pro Pro Leu Asn Leu Ser Ala Lys Thr Glu Leu Val 
            180                 185                 190         


Ala Trp Ala Val Ser Asn Trp Gly Pro Asn Ser Ala Arg Val Arg Tyr 
        195                 200                 205             


Tyr Gln Ser Leu Gln Ala His Leu Lys Val Asp Val Tyr Gly Arg Ser 
    210                 215                 220                 


His Lys Pro Leu Pro Gln Gly Thr Met Met Glu Thr Leu Ser Arg Tyr 
225                 230                 235                 240 


Lys Phe Tyr Leu Ala Phe Glu Asn Ser Leu His Pro Asp Tyr Ile Thr 
                245                 250                 255     


Glu Lys Leu Trp Arg Asn Ala Leu Glu Ala Trp Ala Val Pro Val Val 
            260                 265                 270         


Leu Gly Pro Ser Arg Ser Asn Tyr Glu Arg Phe Leu Pro Pro Asp Ala 
        275                 280                 285             


Phe Ile His Val Asp Asp Phe Gln Ser Pro Lys Asp Leu Ala Arg Tyr 
    290                 295                 300                 


Leu Gln Glu Leu Asp Lys Asp His Ala Arg Tyr Leu Ser Tyr Phe Arg 
305                 310                 315                 320 


Trp Arg Glu Thr Leu Arg Pro Arg Ser Phe Ser Trp Ala Leu Ala Phe 
                325                 330                 335     


Cys Lys Ala Cys Trp Lys Leu Gln Glu Glu Ser Arg Tyr Gln Thr Arg 
            340                 345                 350         


Gly Ile Ala Ala Trp Phe Thr 
        355                 

<210>  506
<211>  2607
<212>  DNA
<213>  Homo sapiens

<400>  506
tctgttccca cttcctcccc gccccaggaa acctgccatg gcctcctggt gagctgtcct     60

catccactgc tcgctgcctc tccagatctt cagttgcttc aggccatttg aacgtatatg    120

agccggtcgt aggggatatg atggcttagc ttgggctcag aggcctgaaa atcgccccca    180

ccaatcacct gtttccccca atctaccctc ctgaaggtca ctgacaaaga cttcattgtc    240

tcctaggaga ggctgccata tatccagggc tgacgtaatt ccatcttaat atcagttaca    300

ttataaaaat ttacctcgtg cctgaggccc cagagcccaa gggtgcaaag cagtaattgg    360

tcaaagttca acttccctcc cactctgggc tcaggctgtc ccctgagggc ctgtgttttg    420

agtctctttc cagaaccttg gtgtgaactt aggtcttggc gtcgggatcc cttttcgtca    480

cactcaggtg acctacaggg agctccgctc gacactgcaa ggcttagacc agttcggtcc    540

aacagagaaa gcaggcaacc accatgtcat ttgaaaacag tttcatcggg atataattcg    600

caacccatac agtgaatcca tttaagatac tctgacccat ggatcccctg ggtgcagcca    660

agccacaatg gccatggcgc cgctgtctgg ccgcactgct atttcagctg ctggtggctg    720

tgtgtttctt ctcctacctg cgtgtgtccc gagacgatgc cactggatcc cctagggctc    780

ccagtgggtc ctcccgacag gacaccactc ccacccgccc caccctcctg atcctgctat    840

ggacatggcc tttccacatc cctgtggctc tgtcccgctg ttcagagatg gtgcccggca    900

cagccgactg ccacatcact gccgaccgca aggtgtaccc acaggcagac acggtcatcg    960

tgcaccactg ggatatcatg tccaacccta agtcacgcct cccaccttcc ccgaggccgc   1020

aggggcagcg ctggatctgg ttcaacttgg agccaccccc taactgccag cacctggaag   1080

ccctggacag atacttcaat ctcaccatgt cctaccgcag cgactccgac atcttcacgc   1140

cctacggctg gctggagccg tggtccggcc agcctgccca cccaccgctc aacctctcgg   1200

ccaagaccga gctggtggcc tgggcggtgt ccaactggaa gccggactca gccagggtgc   1260

gctactacca gagcctgcag gctcatctca aggtggacgt gtacggacgc tcccacaagc   1320

ccctgcccaa ggggaccatg atggagacgc tgtcccggta caagttctac ctggccttcg   1380

agaactcctt gcaccccgac tacatcaccg agaagctgtg gaggaacgcc ctggaggcct   1440

gggccgtgcc cgtggtgctg ggccccagca gaagcaacta cgagaggttc ctgccacccg   1500

acgccttcat ccacgtggac gacttccaga gccccaagga cctggcccgg tacctgcagg   1560

agctggacaa ggaccacgcc cgctacctga gctactttcg ctggcgggag acgctgcggc   1620

ctcgctcctt cagctgggca ctggatttct gcaaggcctg ctggaaactg cagcaggaat   1680

ccaggtacca gacggtgcgc agcatagcgg cttggttcac ctgagaggcc ggcatggtgc   1740

ctgggctgcc gggaacctca tctgcctggg gcctcacctg ctggagtcct ttgtggccaa   1800

ccctctctct tacctgggac ctcacacgct gggcttcacg gctgccagga gcctctcccc   1860

tccagaagac ttgcctgcta gggacctcgc ctgctgggga cctcgcctgt tggggacctc   1920

acctgctggg gacctcacct gctggggacc ttggctgctg gaggctgcac ctactgagga   1980

tgtcggcggt cggggacttt acctgctggg acctgctccc agagaccttg ccacactgaa   2040

tctcacctgc tggggacctc accctggagg gccctgggcc ctggggaact ggcttacttg   2100

gggccccacc cgggagtgat ggttctggct gatttgtttg tgatgttgtt agccgcctgt   2160

gaggggtgca gagagatcat cacggcacgg tttccagatg taatactgca aggaaaaatg   2220

atgacgtgtc tcctcactct agaggggttg gtcccatggg ttaagagctc accccaggtt   2280

ctcacctcag gggttaagag ctcagagttc agacaggtcc aagttcaagc ccaggaccac   2340

cacttatagg gtacaggtgg gatcgactgt aaatgaggac ttctggaaca ttccaaatat   2400

tctggggttg agggaaattg ctgctgtcta caaaatgcca agggtggaca ggcgctgtgg   2460

ctcacgcctg taatcccagc actttgggag gctgaggtag gaggattgat tgaggccaag   2520

agttaaagac cagcctggtc aatatagcaa gaccacgtct ctaaataaaa aataataggc   2580

cggccaggca aaaaaaaaaa aaaaaaa                                       2607


<210>  507
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  507


Met Asp Pro Leu Gly Ala Ala Lys Pro Gln Trp Pro Trp Arg Arg Cys 
1               5                   10                  15      


Leu Ala Ala Leu Leu Phe Gln Leu Leu Val Ala Val Cys Phe Phe Ser 
            20                  25                  30          


Tyr Leu Arg Val Ser Arg Asp Asp Ala Thr Gly Ser Pro Arg Ala Pro 
        35                  40                  45              


Ser Gly Ser Ser Arg Gln Asp Thr Thr Pro Thr Arg Pro Thr Leu Leu 
    50                  55                  60                  


Ile Leu Leu Trp Thr Trp Pro Phe His Ile Pro Val Ala Leu Ser Arg 
65                  70                  75                  80  


Cys Ser Glu Met Val Pro Gly Thr Ala Asp Cys His Ile Thr Ala Asp 
                85                  90                  95      


Arg Lys Val Tyr Pro Gln Ala Asp Thr Val Ile Val His His Trp Asp 
            100                 105                 110         


Ile Met Ser Asn Pro Lys Ser Arg Leu Pro Pro Ser Pro Arg Pro Gln 
        115                 120                 125             


Gly Gln Arg Trp Ile Trp Phe Asn Leu Glu Pro Pro Pro Asn Cys Gln 
    130                 135                 140                 


His Leu Glu Ala Leu Asp Arg Tyr Phe Asn Leu Thr Met Ser Tyr Arg 
145                 150                 155                 160 


Ser Asp Ser Asp Ile Phe Thr Pro Tyr Gly Trp Leu Glu Pro Trp Ser 
                165                 170                 175     


Gly Gln Pro Ala His Pro Pro Leu Asn Leu Ser Ala Lys Thr Glu Leu 
            180                 185                 190         


Val Ala Trp Ala Val Ser Asn Trp Lys Pro Asp Ser Ala Arg Val Arg 
        195                 200                 205             


Tyr Tyr Gln Ser Leu Gln Ala His Leu Lys Val Asp Val Tyr Gly Arg 
    210                 215                 220                 


Ser His Lys Pro Leu Pro Lys Gly Thr Met Met Glu Thr Leu Ser Arg 
225                 230                 235                 240 


Tyr Lys Phe Tyr Leu Ala Phe Glu Asn Ser Leu His Pro Asp Tyr Ile 
                245                 250                 255     


Thr Glu Lys Leu Trp Arg Asn Ala Leu Glu Ala Trp Ala Val Pro Val 
            260                 265                 270         


Val Leu Gly Pro Ser Arg Ser Asn Tyr Glu Arg Phe Leu Pro Pro Asp 
        275                 280                 285             


Ala Phe Ile His Val Asp Asp Phe Gln Ser Pro Lys Asp Leu Ala Arg 
    290                 295                 300                 


Tyr Leu Gln Glu Leu Asp Lys Asp His Ala Arg Tyr Leu Ser Tyr Phe 
305                 310                 315                 320 


Arg Trp Arg Glu Thr Leu Arg Pro Arg Ser Phe Ser Trp Ala Leu Asp 
                325                 330                 335     


Phe Cys Lys Ala Cys Trp Lys Leu Gln Gln Glu Ser Arg Tyr Gln Thr 
            340                 345                 350         


Val Arg Ser Ile Ala Ala Trp Phe Thr 
        355                 360     

<210>  508
<211>  2259
<212>  DNA
<213>  Homo sapiens

<400>  508
tctgttccca cttcctcccc gccccaggaa acctgccatg gcctcctggt gagctgtcct     60

catccactgc tcgctgcctc tccagaacct tggtgtgaac ttaggtcttg gcgtcgggat    120

cccttttcgt cacactcagg tgacctacag ggagctccgc tcgacactgc aaggcttaga    180

ccagttcggt ccaacagaga aagcaggcaa ccaccatgtc atttgaaaac agtttcatcg    240

ggatataatt cgcaacccat acagtgaatc catttaagat actctgaccc atggatcccc    300

tgggtgcagc caagccacaa tggccatggc gccgctgtct ggccgcactg ctatttcagc    360

tgctggtggc tgtgtgtttc ttctcctacc tgcgtgtgtc ccgagacgat gccactggat    420

cccctagggc tcccagtggg tcctcccgac aggacaccac tcccacccgc cccaccctcc    480

tgatcctgct atggacatgg cctttccaca tccctgtggc tctgtcccgc tgttcagaga    540

tggtgcccgg cacagccgac tgccacatca ctgccgaccg caaggtgtac ccacaggcag    600

acacggtcat cgtgcaccac tgggatatca tgtccaaccc taagtcacgc ctcccacctt    660

ccccgaggcc gcaggggcag cgctggatct ggttcaactt ggagccaccc cctaactgcc    720

agcacctgga agccctggac agatacttca atctcaccat gtcctaccgc agcgactccg    780

acatcttcac gccctacggc tggctggagc cgtggtccgg ccagcctgcc cacccaccgc    840

tcaacctctc ggccaagacc gagctggtgg cctgggcggt gtccaactgg aagccggact    900

cagccagggt gcgctactac cagagcctgc aggctcatct caaggtggac gtgtacggac    960

gctcccacaa gcccctgccc aaggggacca tgatggagac gctgtcccgg tacaagttct   1020

acctggcctt cgagaactcc ttgcaccccg actacatcac cgagaagctg tggaggaacg   1080

ccctggaggc ctgggccgtg cccgtggtgc tgggccccag cagaagcaac tacgagaggt   1140

tcctgccacc cgacgccttc atccacgtgg acgacttcca gagccccaag gacctggccc   1200

ggtacctgca ggagctggac aaggaccacg cccgctacct gagctacttt cgctggcggg   1260

agacgctgcg gcctcgctcc ttcagctggg cactggattt ctgcaaggcc tgctggaaac   1320

tgcagcagga atccaggtac cagacggtgc gcagcatagc ggcttggttc acctgagagg   1380

ccggcatggt gcctgggctg ccgggaacct catctgcctg gggcctcacc tgctggagtc   1440

ctttgtggcc aaccctctct cttacctggg acctcacacg ctgggcttca cggctgccag   1500

gagcctctcc cctccagaag acttgcctgc tagggacctc gcctgctggg gacctcgcct   1560

gttggggacc tcacctgctg gggacctcac ctgctgggga ccttggctgc tggaggctgc   1620

acctactgag gatgtcggcg gtcggggact ttacctgctg ggacctgctc ccagagacct   1680

tgccacactg aatctcacct gctggggacc tcaccctgga gggccctggg ccctggggaa   1740

ctggcttact tggggcccca cccgggagtg atggttctgg ctgatttgtt tgtgatgttg   1800

ttagccgcct gtgaggggtg cagagagatc atcacggcac ggtttccaga tgtaatactg   1860

caaggaaaaa tgatgacgtg tctcctcact ctagaggggt tggtcccatg ggttaagagc   1920

tcaccccagg ttctcacctc aggggttaag agctcagagt tcagacaggt ccaagttcaa   1980

gcccaggacc accacttata gggtacaggt gggatcgact gtaaatgagg acttctggaa   2040

cattccaaat attctggggt tgagggaaat tgctgctgtc tacaaaatgc caagggtgga   2100

caggcgctgt ggctcacgcc tgtaatccca gcactttggg aggctgaggt aggaggattg   2160

attgaggcca agagttaaag accagcctgg tcaatatagc aagaccacgt ctctaaataa   2220

aaaataatag gccggccagg caaaaaaaaa aaaaaaaaa                          2259


<210>  509
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  509


Met Asp Pro Leu Gly Ala Ala Lys Pro Gln Trp Pro Trp Arg Arg Cys 
1               5                   10                  15      


Leu Ala Ala Leu Leu Phe Gln Leu Leu Val Ala Val Cys Phe Phe Ser 
            20                  25                  30          


Tyr Leu Arg Val Ser Arg Asp Asp Ala Thr Gly Ser Pro Arg Ala Pro 
        35                  40                  45              


Ser Gly Ser Ser Arg Gln Asp Thr Thr Pro Thr Arg Pro Thr Leu Leu 
    50                  55                  60                  


Ile Leu Leu Trp Thr Trp Pro Phe His Ile Pro Val Ala Leu Ser Arg 
65                  70                  75                  80  


Cys Ser Glu Met Val Pro Gly Thr Ala Asp Cys His Ile Thr Ala Asp 
                85                  90                  95      


Arg Lys Val Tyr Pro Gln Ala Asp Thr Val Ile Val His His Trp Asp 
            100                 105                 110         


Ile Met Ser Asn Pro Lys Ser Arg Leu Pro Pro Ser Pro Arg Pro Gln 
        115                 120                 125             


Gly Gln Arg Trp Ile Trp Phe Asn Leu Glu Pro Pro Pro Asn Cys Gln 
    130                 135                 140                 


His Leu Glu Ala Leu Asp Arg Tyr Phe Asn Leu Thr Met Ser Tyr Arg 
145                 150                 155                 160 


Ser Asp Ser Asp Ile Phe Thr Pro Tyr Gly Trp Leu Glu Pro Trp Ser 
                165                 170                 175     


Gly Gln Pro Ala His Pro Pro Leu Asn Leu Ser Ala Lys Thr Glu Leu 
            180                 185                 190         


Val Ala Trp Ala Val Ser Asn Trp Lys Pro Asp Ser Ala Arg Val Arg 
        195                 200                 205             


Tyr Tyr Gln Ser Leu Gln Ala His Leu Lys Val Asp Val Tyr Gly Arg 
    210                 215                 220                 


Ser His Lys Pro Leu Pro Lys Gly Thr Met Met Glu Thr Leu Ser Arg 
225                 230                 235                 240 


Tyr Lys Phe Tyr Leu Ala Phe Glu Asn Ser Leu His Pro Asp Tyr Ile 
                245                 250                 255     


Thr Glu Lys Leu Trp Arg Asn Ala Leu Glu Ala Trp Ala Val Pro Val 
            260                 265                 270         


Val Leu Gly Pro Ser Arg Ser Asn Tyr Glu Arg Phe Leu Pro Pro Asp 
        275                 280                 285             


Ala Phe Ile His Val Asp Asp Phe Gln Ser Pro Lys Asp Leu Ala Arg 
    290                 295                 300                 


Tyr Leu Gln Glu Leu Asp Lys Asp His Ala Arg Tyr Leu Ser Tyr Phe 
305                 310                 315                 320 


Arg Trp Arg Glu Thr Leu Arg Pro Arg Ser Phe Ser Trp Ala Leu Asp 
                325                 330                 335     


Phe Cys Lys Ala Cys Trp Lys Leu Gln Gln Glu Ser Arg Tyr Gln Thr 
            340                 345                 350         


Val Arg Ser Ile Ala Ala Trp Phe Thr 
        355                 360     

<210>  510
<211>  2205
<212>  DNA
<213>  Homo sapiens

<400>  510
tctgttccca cttcctcccc gccccaggaa acctgccatg gcctcctggt gagctgtcct     60

catccactgc tcgctgcctc tccaggtgac ctacagggag ctccgctcga cactgcaagg    120

cttagaccag ttcggtccaa cagagaaagc aggcaaccac catgtcattt gaaaacagtt    180

tcatcgggat ataattcgca acccatacag tgaatccatt taagatactc tgacccatgg    240

atcccctggg tgcagccaag ccacaatggc catggcgccg ctgtctggcc gcactgctat    300

ttcagctgct ggtggctgtg tgtttcttct cctacctgcg tgtgtcccga gacgatgcca    360

ctggatcccc tagggctccc agtgggtcct cccgacagga caccactccc acccgcccca    420

ccctcctgat cctgctatgg acatggcctt tccacatccc tgtggctctg tcccgctgtt    480

cagagatggt gcccggcaca gccgactgcc acatcactgc cgaccgcaag gtgtacccac    540

aggcagacac ggtcatcgtg caccactggg atatcatgtc caaccctaag tcacgcctcc    600

caccttcccc gaggccgcag gggcagcgct ggatctggtt caacttggag ccacccccta    660

actgccagca cctggaagcc ctggacagat acttcaatct caccatgtcc taccgcagcg    720

actccgacat cttcacgccc tacggctggc tggagccgtg gtccggccag cctgcccacc    780

caccgctcaa cctctcggcc aagaccgagc tggtggcctg ggcggtgtcc aactggaagc    840

cggactcagc cagggtgcgc tactaccaga gcctgcaggc tcatctcaag gtggacgtgt    900

acggacgctc ccacaagccc ctgcccaagg ggaccatgat ggagacgctg tcccggtaca    960

agttctacct ggccttcgag aactccttgc accccgacta catcaccgag aagctgtgga   1020

ggaacgccct ggaggcctgg gccgtgcccg tggtgctggg ccccagcaga agcaactacg   1080

agaggttcct gccacccgac gccttcatcc acgtggacga cttccagagc cccaaggacc   1140

tggcccggta cctgcaggag ctggacaagg accacgcccg ctacctgagc tactttcgct   1200

ggcgggagac gctgcggcct cgctccttca gctgggcact ggatttctgc aaggcctgct   1260

ggaaactgca gcaggaatcc aggtaccaga cggtgcgcag catagcggct tggttcacct   1320

gagaggccgg catggtgcct gggctgccgg gaacctcatc tgcctggggc ctcacctgct   1380

ggagtccttt gtggccaacc ctctctctta cctgggacct cacacgctgg gcttcacggc   1440

tgccaggagc ctctcccctc cagaagactt gcctgctagg gacctcgcct gctggggacc   1500

tcgcctgttg gggacctcac ctgctgggga cctcacctgc tggggacctt ggctgctgga   1560

ggctgcacct actgaggatg tcggcggtcg gggactttac ctgctgggac ctgctcccag   1620

agaccttgcc acactgaatc tcacctgctg gggacctcac cctggagggc cctgggccct   1680

ggggaactgg cttacttggg gccccacccg ggagtgatgg ttctggctga tttgtttgtg   1740

atgttgttag ccgcctgtga ggggtgcaga gagatcatca cggcacggtt tccagatgta   1800

atactgcaag gaaaaatgat gacgtgtctc ctcactctag aggggttggt cccatgggtt   1860

aagagctcac cccaggttct cacctcaggg gttaagagct cagagttcag acaggtccaa   1920

gttcaagccc aggaccacca cttatagggt acaggtggga tcgactgtaa atgaggactt   1980

ctggaacatt ccaaatattc tggggttgag ggaaattgct gctgtctaca aaatgccaag   2040

ggtggacagg cgctgtggct cacgcctgta atcccagcac tttgggaggc tgaggtagga   2100

ggattgattg aggccaagag ttaaagacca gcctggtcaa tatagcaaga ccacgtctct   2160

aaataaaaaa taataggccg gccaggcaaa aaaaaaaaaa aaaaa                   2205


<210>  511
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  511


Met Asp Pro Leu Gly Ala Ala Lys Pro Gln Trp Pro Trp Arg Arg Cys 
1               5                   10                  15      


Leu Ala Ala Leu Leu Phe Gln Leu Leu Val Ala Val Cys Phe Phe Ser 
            20                  25                  30          


Tyr Leu Arg Val Ser Arg Asp Asp Ala Thr Gly Ser Pro Arg Ala Pro 
        35                  40                  45              


Ser Gly Ser Ser Arg Gln Asp Thr Thr Pro Thr Arg Pro Thr Leu Leu 
    50                  55                  60                  


Ile Leu Leu Trp Thr Trp Pro Phe His Ile Pro Val Ala Leu Ser Arg 
65                  70                  75                  80  


Cys Ser Glu Met Val Pro Gly Thr Ala Asp Cys His Ile Thr Ala Asp 
                85                  90                  95      


Arg Lys Val Tyr Pro Gln Ala Asp Thr Val Ile Val His His Trp Asp 
            100                 105                 110         


Ile Met Ser Asn Pro Lys Ser Arg Leu Pro Pro Ser Pro Arg Pro Gln 
        115                 120                 125             


Gly Gln Arg Trp Ile Trp Phe Asn Leu Glu Pro Pro Pro Asn Cys Gln 
    130                 135                 140                 


His Leu Glu Ala Leu Asp Arg Tyr Phe Asn Leu Thr Met Ser Tyr Arg 
145                 150                 155                 160 


Ser Asp Ser Asp Ile Phe Thr Pro Tyr Gly Trp Leu Glu Pro Trp Ser 
                165                 170                 175     


Gly Gln Pro Ala His Pro Pro Leu Asn Leu Ser Ala Lys Thr Glu Leu 
            180                 185                 190         


Val Ala Trp Ala Val Ser Asn Trp Lys Pro Asp Ser Ala Arg Val Arg 
        195                 200                 205             


Tyr Tyr Gln Ser Leu Gln Ala His Leu Lys Val Asp Val Tyr Gly Arg 
    210                 215                 220                 


Ser His Lys Pro Leu Pro Lys Gly Thr Met Met Glu Thr Leu Ser Arg 
225                 230                 235                 240 


Tyr Lys Phe Tyr Leu Ala Phe Glu Asn Ser Leu His Pro Asp Tyr Ile 
                245                 250                 255     


Thr Glu Lys Leu Trp Arg Asn Ala Leu Glu Ala Trp Ala Val Pro Val 
            260                 265                 270         


Val Leu Gly Pro Ser Arg Ser Asn Tyr Glu Arg Phe Leu Pro Pro Asp 
        275                 280                 285             


Ala Phe Ile His Val Asp Asp Phe Gln Ser Pro Lys Asp Leu Ala Arg 
    290                 295                 300                 


Tyr Leu Gln Glu Leu Asp Lys Asp His Ala Arg Tyr Leu Ser Tyr Phe 
305                 310                 315                 320 


Arg Trp Arg Glu Thr Leu Arg Pro Arg Ser Phe Ser Trp Ala Leu Asp 
                325                 330                 335     


Phe Cys Lys Ala Cys Trp Lys Leu Gln Gln Glu Ser Arg Tyr Gln Thr 
            340                 345                 350         


Val Arg Ser Ile Ala Ala Trp Phe Thr 
        355                 360     

<210>  512
<211>  2066
<212>  DNA
<213>  Homo sapiens

<400>  512
tctgttccca cttcctcccc gccccaggaa acctgccatg gcctcctggt gagctgtcct     60

catccactgc tcgctgcctc tccagatact ctgacccatg gatcccctgg gtgcagccaa    120

gccacaatgg ccatggcgcc gctgtctggc cgcactgcta tttcagctgc tggtggctgt    180

gtgtttcttc tcctacctgc gtgtgtcccg agacgatgcc actggatccc ctagggctcc    240

cagtgggtcc tcccgacagg acaccactcc cacccgcccc accctcctga tcctgctatg    300

gacatggcct ttccacatcc ctgtggctct gtcccgctgt tcagagatgg tgcccggcac    360

agccgactgc cacatcactg ccgaccgcaa ggtgtaccca caggcagaca cggtcatcgt    420

gcaccactgg gatatcatgt ccaaccctaa gtcacgcctc ccaccttccc cgaggccgca    480

ggggcagcgc tggatctggt tcaacttgga gccaccccct aactgccagc acctggaagc    540

cctggacaga tacttcaatc tcaccatgtc ctaccgcagc gactccgaca tcttcacgcc    600

ctacggctgg ctggagccgt ggtccggcca gcctgcccac ccaccgctca acctctcggc    660

caagaccgag ctggtggcct gggcggtgtc caactggaag ccggactcag ccagggtgcg    720

ctactaccag agcctgcagg ctcatctcaa ggtggacgtg tacggacgct cccacaagcc    780

cctgcccaag gggaccatga tggagacgct gtcccggtac aagttctacc tggccttcga    840

gaactccttg caccccgact acatcaccga gaagctgtgg aggaacgccc tggaggcctg    900

ggccgtgccc gtggtgctgg gccccagcag aagcaactac gagaggttcc tgccacccga    960

cgccttcatc cacgtggacg acttccagag ccccaaggac ctggcccggt acctgcagga   1020

gctggacaag gaccacgccc gctacctgag ctactttcgc tggcgggaga cgctgcggcc   1080

tcgctccttc agctgggcac tggatttctg caaggcctgc tggaaactgc agcaggaatc   1140

caggtaccag acggtgcgca gcatagcggc ttggttcacc tgagaggccg gcatggtgcc   1200

tgggctgccg ggaacctcat ctgcctgggg cctcacctgc tggagtcctt tgtggccaac   1260

cctctctctt acctgggacc tcacacgctg ggcttcacgg ctgccaggag cctctcccct   1320

ccagaagact tgcctgctag ggacctcgcc tgctggggac ctcgcctgtt ggggacctca   1380

cctgctgggg acctcacctg ctggggacct tggctgctgg aggctgcacc tactgaggat   1440

gtcggcggtc ggggacttta cctgctggga cctgctccca gagaccttgc cacactgaat   1500

ctcacctgct ggggacctca ccctggaggg ccctgggccc tggggaactg gcttacttgg   1560

ggccccaccc gggagtgatg gttctggctg atttgtttgt gatgttgtta gccgcctgtg   1620

aggggtgcag agagatcatc acggcacggt ttccagatgt aatactgcaa ggaaaaatga   1680

tgacgtgtct cctcactcta gaggggttgg tcccatgggt taagagctca ccccaggttc   1740

tcacctcagg ggttaagagc tcagagttca gacaggtcca agttcaagcc caggaccacc   1800

acttataggg tacaggtggg atcgactgta aatgaggact tctggaacat tccaaatatt   1860

ctggggttga gggaaattgc tgctgtctac aaaatgccaa gggtggacag gcgctgtggc   1920

tcacgcctgt aatcccagca ctttgggagg ctgaggtagg aggattgatt gaggccaaga   1980

gttaaagacc agcctggtca atatagcaag accacgtctc taaataaaaa ataataggcc   2040

ggccaggcaa aaaaaaaaaa aaaaaa                                        2066


<210>  513
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  513


Met Asp Pro Leu Gly Ala Ala Lys Pro Gln Trp Pro Trp Arg Arg Cys 
1               5                   10                  15      


Leu Ala Ala Leu Leu Phe Gln Leu Leu Val Ala Val Cys Phe Phe Ser 
            20                  25                  30          


Tyr Leu Arg Val Ser Arg Asp Asp Ala Thr Gly Ser Pro Arg Ala Pro 
        35                  40                  45              


Ser Gly Ser Ser Arg Gln Asp Thr Thr Pro Thr Arg Pro Thr Leu Leu 
    50                  55                  60                  


Ile Leu Leu Trp Thr Trp Pro Phe His Ile Pro Val Ala Leu Ser Arg 
65                  70                  75                  80  


Cys Ser Glu Met Val Pro Gly Thr Ala Asp Cys His Ile Thr Ala Asp 
                85                  90                  95      


Arg Lys Val Tyr Pro Gln Ala Asp Thr Val Ile Val His His Trp Asp 
            100                 105                 110         


Ile Met Ser Asn Pro Lys Ser Arg Leu Pro Pro Ser Pro Arg Pro Gln 
        115                 120                 125             


Gly Gln Arg Trp Ile Trp Phe Asn Leu Glu Pro Pro Pro Asn Cys Gln 
    130                 135                 140                 


His Leu Glu Ala Leu Asp Arg Tyr Phe Asn Leu Thr Met Ser Tyr Arg 
145                 150                 155                 160 


Ser Asp Ser Asp Ile Phe Thr Pro Tyr Gly Trp Leu Glu Pro Trp Ser 
                165                 170                 175     


Gly Gln Pro Ala His Pro Pro Leu Asn Leu Ser Ala Lys Thr Glu Leu 
            180                 185                 190         


Val Ala Trp Ala Val Ser Asn Trp Lys Pro Asp Ser Ala Arg Val Arg 
        195                 200                 205             


Tyr Tyr Gln Ser Leu Gln Ala His Leu Lys Val Asp Val Tyr Gly Arg 
    210                 215                 220                 


Ser His Lys Pro Leu Pro Lys Gly Thr Met Met Glu Thr Leu Ser Arg 
225                 230                 235                 240 


Tyr Lys Phe Tyr Leu Ala Phe Glu Asn Ser Leu His Pro Asp Tyr Ile 
                245                 250                 255     


Thr Glu Lys Leu Trp Arg Asn Ala Leu Glu Ala Trp Ala Val Pro Val 
            260                 265                 270         


Val Leu Gly Pro Ser Arg Ser Asn Tyr Glu Arg Phe Leu Pro Pro Asp 
        275                 280                 285             


Ala Phe Ile His Val Asp Asp Phe Gln Ser Pro Lys Asp Leu Ala Arg 
    290                 295                 300                 


Tyr Leu Gln Glu Leu Asp Lys Asp His Ala Arg Tyr Leu Ser Tyr Phe 
305                 310                 315                 320 


Arg Trp Arg Glu Thr Leu Arg Pro Arg Ser Phe Ser Trp Ala Leu Asp 
                325                 330                 335     


Phe Cys Lys Ala Cys Trp Lys Leu Gln Gln Glu Ser Arg Tyr Gln Thr 
            340                 345                 350         


Val Arg Ser Ile Ala Ala Trp Phe Thr 
        355                 360     

<210>  514
<211>  1988
<212>  DNA
<213>  Homo sapiens

<400>  514
gattacagac atgagccacc tcgcccagcc ttttcatggc tgagtgatat tccattgtgt     60

ggatggatca cactagctac tctgacccat ggatcccctg ggcccagcca agccacagtg    120

gctgtggcgc cgctgtctgg ccgggctgct gtttcagctg ctggtggctg tgtgtttctt    180

ctcctacctg cgtgtgtccc gagacgatgc cactggatcc cctaggccag ggcttatggc    240

agtggaacct gtcaccgggg ctcccaatgg gtcccgctgc caggacagca tggcgacccc    300

tgcccacccc accctactga tcctgctgtg gacgtggcct tttaacacac ccgtggctct    360

gccccgctgc tcagagatgg tgcccggcgc ggccgactgc aacatcactg ccgactccag    420

tgtgtaccca caggcagacg cggtcatcgt gcaccactgg gatatcatgt acaaccccag    480

tgccaacctc ccgcccccca ccaggccgca ggggcagcgc tggatctggt tcagcatgga    540

gtcccccagc aactgccggc acctggaagc cctggacgga tacttcaatc tcaccatgtc    600

ctaccgcagc gactccgaca tcttcacgcc ctacggctgg ctggagccgt ggtccggcca    660

gcctgcccac ccaccgctca acctctcggc caagaccgag ctggtggcct gggcggtgtc    720

caactggaag ccggactcgg ccagggtgcg ctactaccag agcctgcagg ctcatctcaa    780

ggtggacgtg tacggacgct cccacaagcc cctgcccaag gggaccatga tggagacgct    840

gtcccggtac aagttctatc tggccttcga gaactccttg caccccgact acatcaccga    900

gaagctgtgg aggaacgccc tggaggcctg ggccgtgccc gtggtgctgg gccccagcag    960

aagcaactac gagaggttcc tgccacccga cgccttcatc cacgtggacg acttccagag   1020

ccccaaggac ctggcccggt acctgcagga gctggacaag gaccacgccc gctacctgag   1080

ctactttcac tggcgggaga cgctgcggcc tcgctccttc agctgggcac tggctttctg   1140

caaggcctgc tggaagctgc agcaggaatc taggtaccag acggtgcgca gcatagcggc   1200

ttggttcacc tgagaggccg gcatggggcc tgggctgccg ggacctcact ttcccagggc   1260

ctcacctacc tagggtctca ctagtcgggg gatttaccta cctggggcct cggctgcctg   1320

gggcctcggc tgcctggggt ctcacctgcc tggggcctca cctgctggag tctttggtgg   1380

ccaggcatgt gacttacctg ggatttcact tgccgggctt cactgccagg agcctcccct   1440

gctggggacc ttgccagctg gggctgggga tggtgcctac tggggacctt gctttctgga   1500

ggctgcacct actgaggatc tcggctgttg gggactttac ctgctgggac ctgctcccag   1560

agaccttgcc acactgaatg tcacctgcta ggagcctcac ccgctgggag gcacagggcc   1620

caagggagct ggatgtgttg cccaaggtgt gcagggcagg tcagggaagg gcagggtccc   1680

ctaaggagga gggcgaaggg tatgtgtgtg accatcagca gtggtgtgca catggctggg   1740

ggacactcgg tttgaccgcc agcggatggg tgtcacaaat gcatcactat gggtgtgacc   1800

tcggcgtgac tctgatagtg cctgtggatg tgttgcgatg cctcaccctg gagggcactg   1860

ggccctgaga acgggtgccc ttgaggccct gcccccgggc gatggtgcag gctggtttgc   1920

ttgtggtttt attgctgttg ttaaccaccc atgaggggtg caaacagata atgctgttaa   1980

cattttca                                                            1988


<210>  515
<211>  374
<212>  PRT
<213>  Homo sapiens

<400>  515


Met Asp Pro Leu Gly Pro Ala Lys Pro Gln Trp Leu Trp Arg Arg Cys 
1               5                   10                  15      


Leu Ala Gly Leu Leu Phe Gln Leu Leu Val Ala Val Cys Phe Phe Ser 
            20                  25                  30          


Tyr Leu Arg Val Ser Arg Asp Asp Ala Thr Gly Ser Pro Arg Pro Gly 
        35                  40                  45              


Leu Met Ala Val Glu Pro Val Thr Gly Ala Pro Asn Gly Ser Arg Cys 
    50                  55                  60                  


Gln Asp Ser Met Ala Thr Pro Ala His Pro Thr Leu Leu Ile Leu Leu 
65                  70                  75                  80  


Trp Thr Trp Pro Phe Asn Thr Pro Val Ala Leu Pro Arg Cys Ser Glu 
                85                  90                  95      


Met Val Pro Gly Ala Ala Asp Cys Asn Ile Thr Ala Asp Ser Ser Val 
            100                 105                 110         


Tyr Pro Gln Ala Asp Ala Val Ile Val His His Trp Asp Ile Met Tyr 
        115                 120                 125             


Asn Pro Ser Ala Asn Leu Pro Pro Pro Thr Arg Pro Gln Gly Gln Arg 
    130                 135                 140                 


Trp Ile Trp Phe Ser Met Glu Ser Pro Ser Asn Cys Arg His Leu Glu 
145                 150                 155                 160 


Ala Leu Asp Gly Tyr Phe Asn Leu Thr Met Ser Tyr Arg Ser Asp Ser 
                165                 170                 175     


Asp Ile Phe Thr Pro Tyr Gly Trp Leu Glu Pro Trp Ser Gly Gln Pro 
            180                 185                 190         


Ala His Pro Pro Leu Asn Leu Ser Ala Lys Thr Glu Leu Val Ala Trp 
        195                 200                 205             


Ala Val Ser Asn Trp Lys Pro Asp Ser Ala Arg Val Arg Tyr Tyr Gln 
    210                 215                 220                 


Ser Leu Gln Ala His Leu Lys Val Asp Val Tyr Gly Arg Ser His Lys 
225                 230                 235                 240 


Pro Leu Pro Lys Gly Thr Met Met Glu Thr Leu Ser Arg Tyr Lys Phe 
                245                 250                 255     


Tyr Leu Ala Phe Glu Asn Ser Leu His Pro Asp Tyr Ile Thr Glu Lys 
            260                 265                 270         


Leu Trp Arg Asn Ala Leu Glu Ala Trp Ala Val Pro Val Val Leu Gly 
        275                 280                 285             


Pro Ser Arg Ser Asn Tyr Glu Arg Phe Leu Pro Pro Asp Ala Phe Ile 
    290                 295                 300                 


His Val Asp Asp Phe Gln Ser Pro Lys Asp Leu Ala Arg Tyr Leu Gln 
305                 310                 315                 320 


Glu Leu Asp Lys Asp His Ala Arg Tyr Leu Ser Tyr Phe His Trp Arg 
                325                 330                 335     


Glu Thr Leu Arg Pro Arg Ser Phe Ser Trp Ala Leu Ala Phe Cys Lys 
            340                 345                 350         


Ala Cys Trp Lys Leu Gln Gln Glu Ser Arg Tyr Gln Thr Val Arg Ser 
        355                 360                 365             


Ile Ala Ala Trp Phe Thr 
    370                 

<210>  516
<211>  819
<212>  DNA
<213>  Homo sapiens

<400>  516
acctaggact ccctgagctg ggactagcga aatctgtctg cactgatcgc agtcgtcctc     60

agtttcaccc tctaggaatc ggcctgggga tgcacgtgct actctcttcc tccaggccgg    120

tccccggcgc gtgcgcgcga tccatgtcca tgtccgcgcc tatcaataaa gttgctcact    180

tgttgccggc ccgctagccc gaaaggttgc gcgcgcagac cgagaagtct cgcgatagcc    240

agccgcggct gcccttgcgc ttcccgagct ggcggggtcc gtggtgcggg atcgagattg    300

cgggctatgg cgccgaaggt ttttcgtcag tactgggata tccccgatgg caccgattgc    360

caccgcaaag cctacagcac caccagtatt gccagcgtcg ctggcctgac cgccgctgcc    420

tacagagtca cactcaatcc tccgggcacc ttccttgaag gagtggctaa ggttggacaa    480

tacacgttca ctgcagctgc tgtcggggcc gtgtttggcc tcaccacctg catcagcgcc    540

catgtccgcg agaagcccga cgaccccctg aactacttcc tcggtggctg cgccggaggc    600

ctgactctgg gagcacgcac gcacaactac gggattggcg ccgccgcctg cgtgtacttt    660

ggcatagcgg cctccctggt caagatgggc cggctggagg gctgggaggt gtttgcaaaa    720

cccaaggtgt gagccctgtg cctgccggga cctccagcct gcagaatgcg tccagaaata    780

aattctgtgt ctgtgtgtga aaaaaaaaaa aaaaaaaaa                           819


<210>  517
<211>  141
<212>  PRT
<213>  Homo sapiens

<400>  517


Met Ala Pro Lys Val Phe Arg Gln Tyr Trp Asp Ile Pro Asp Gly Thr 
1               5                   10                  15      


Asp Cys His Arg Lys Ala Tyr Ser Thr Thr Ser Ile Ala Ser Val Ala 
            20                  25                  30          


Gly Leu Thr Ala Ala Ala Tyr Arg Val Thr Leu Asn Pro Pro Gly Thr 
        35                  40                  45              


Phe Leu Glu Gly Val Ala Lys Val Gly Gln Tyr Thr Phe Thr Ala Ala 
    50                  55                  60                  


Ala Val Gly Ala Val Phe Gly Leu Thr Thr Cys Ile Ser Ala His Val 
65                  70                  75                  80  


Arg Glu Lys Pro Asp Asp Pro Leu Asn Tyr Phe Leu Gly Gly Cys Ala 
                85                  90                  95      


Gly Gly Leu Thr Leu Gly Ala Arg Thr His Asn Tyr Gly Ile Gly Ala 
            100                 105                 110         


Ala Ala Cys Val Tyr Phe Gly Ile Ala Ala Ser Leu Val Lys Met Gly 
        115                 120                 125             


Arg Leu Glu Gly Trp Glu Val Phe Ala Lys Pro Lys Val 
    130                 135                 140     

<210>  518
<211>  1708
<212>  DNA
<213>  Homo sapiens

<400>  518
agttccgggc cgcctggggg cgtggccggg cctgtacagc agcctgggcc atgtcggcgc     60

cgccggccct gcagatccgg gaggcaaacg cacacctggc agccgtgcac cggcgcgcag    120

cggagctgga ggcgcggctg gacgcggcgg agcgcacggt gcacgcccaa gccgagcgcc    180

tggccctcca cgaccagcag ctgcgcgccg ccctagacga actgggtcgc gccaaggacc    240

gtgagattgc cacactccag gagcagctga tgacctcaga agccactgtc cacagcctgc    300

aggccaccgt gcaccagagg gacgagctca ttaggcagtt gcagccccgg gctgagctgc    360

tgcaggacat ctgccgccgc cggccacccc tggctgggct gctggatgcc ctggctgagg    420

ctgagcgcct ggggcccctg ccggccagtg accccggcca cccacccccc ggtgggcctg    480

gtccacccct tgacaacagc actggggaag aggcggacag ggaccacctc cagcctgcag    540

tgtttgggac cacagtgtga gcccggaatg cagattacag aatggagaca gaaagccact    600

gctgtcagtg tccttgggag tcaccagcac cctgcagggg gaccctacgg cagagccaaa    660

gtcctgtcta agcatcagaa caggctgaac agtcaaaaag ttttcaaata ggcccacagg    720

ccaggtgcag acgtttaacc cagacagaag tgttcttgtt tgtttttaag ctttgaatca    780

gtcacccttg ctaaaaacct ggcaatgcaa acacaaagat ctggatttct ggcaagactt    840

ggccaagctt gcctggagtt cagggcaccc tctttagcca gggtgtgagt ttctgttttt    900

tgtttttttt tttttaagac agagtcccac tctgtcgccc tggctggggt gcagtggtgc    960

gattttggct aactgcaacc tccgcctccc aggttcaagc gattctcctg tctcatcctt   1020

cagagtagct gggattacag gcgcccacca ccacacccgg atattttata tttttggtag   1080

agaccgggga ggggaggggg tttcaccatg ttgaccaggc tggtctcaaa ctcctgacct   1140

taggtgatcc acccgcctcg gccttcgaaa gtgctgcagt tataggtgta agccaccgcg   1200

cccggcccta gcctagcttt tgtagcatgc aactgtctcc tttttatacg ccctaaagaa   1260

tatatttttg aactccttgt ttctgcgctg tccttcttag cccaggacat tcagggtgct   1320

ttgcttgttg tcaaaccagg gaaaggagaa aactcctgtg cctttctggg ccagcctgtc   1380

accctggcct ggtcggcagc cattccccta cctcctcact caggaactgt cacaccagga   1440

accggcgagg ggcacagcct gtttcagacc agaaaggtcg gaggccaccc acggccttca   1500

ggatggcgcc cgcctgcctg cctggcaaca gtgacccctc agtgcagtaa caatgggccc   1560

attttctcct ctggatgaac aaggaggggg gttgtttgta caaaggaaag gcaggctggg   1620

gcctgtctgt gctcaagaat aaaccggatg atttcctggc ctgggggcaa aaaaaaaaaa   1680

aaaaaaaaaa aaaaaaaaaa aaaaaaaa                                      1708


<210>  519
<211>  169
<212>  PRT
<213>  Homo sapiens

<400>  519


Met Ser Ala Pro Pro Ala Leu Gln Ile Arg Glu Ala Asn Ala His Leu 
1               5                   10                  15      


Ala Ala Val His Arg Arg Ala Ala Glu Leu Glu Ala Arg Leu Asp Ala 
            20                  25                  30          


Ala Glu Arg Thr Val His Ala Gln Ala Glu Arg Leu Ala Leu His Asp 
        35                  40                  45              


Gln Gln Leu Arg Ala Ala Leu Asp Glu Leu Gly Arg Ala Lys Asp Arg 
    50                  55                  60                  


Glu Ile Ala Thr Leu Gln Glu Gln Leu Met Thr Ser Glu Ala Thr Val 
65                  70                  75                  80  


His Ser Leu Gln Ala Thr Val His Gln Arg Asp Glu Leu Ile Arg Gln 
                85                  90                  95      


Leu Gln Pro Arg Ala Glu Leu Leu Gln Asp Ile Cys Arg Arg Arg Pro 
            100                 105                 110         


Pro Leu Ala Gly Leu Leu Asp Ala Leu Ala Glu Ala Glu Arg Leu Gly 
        115                 120                 125             


Pro Leu Pro Ala Ser Asp Pro Gly His Pro Pro Pro Gly Gly Pro Gly 
    130                 135                 140                 


Pro Pro Leu Asp Asn Ser Thr Gly Glu Glu Ala Asp Arg Asp His Leu 
145                 150                 155                 160 


Gln Pro Ala Val Phe Gly Thr Thr Val 
                165                 

<210>  520
<211>  1613
<212>  DNA
<213>  Homo sapiens

<400>  520
acagtgcatt catgcagctg ggccccaccc catctccaga ggcaccttcc actagcaaca     60

gtctccccag gcacaacaca gctaacacaa ggccccgcag gcaggactct gggacagacg    120

caggccagct gcccagagcc cagaccaagc atggacgccg tggatgccac catggagaaa    180

ctccgggcac agtgcctgtc ccgcggggcc tcgggcatcc agggcctggc caggtttttc    240

cgccaactag accgggacgg gagcagatcc ctggacgctg atgagttccg gcagggtctg    300

gccaaactcg ggctggtgct ggaccaggcg gaggcagagg gtgtgtgcag gaagtgggac    360

cgcaatggca gcgggacgct ggatctggag gagttccttc gggcgctgcg gccccccatg    420

tcccaggccc gggaggctgt catcgcagct gcatttgcca agctggaccg cagtggggac    480

ggcgtcgtga cggtggacga cctccgcggg gtgtacagtg gccgtgccca ccccaaggtg    540

cgcagtgggg agtggaccga ggacgaggtg ctgcgccgct tcctggacaa cttcgactcc    600

tctgagaagg acgggcaggt cacactggcg gaattccagg actactacag cggcgtgagt    660

gcctccatga acacggatga ggagttcgtg gccatgatga ccagtgcctg gcagctgtga    720

gcagctccgg ctcagccctg ctgccctggc ctgtcactcc ccacccctgc cggagacctc    780

ccttccctgg gccccttctc tcctgggcag ccacaccaca gagcggggag gggcaggtgg    840

gggaatggag gctgcaggac tggctagacc aggtccctgc cggtccacca ggcggaggtg    900

ggacaaaggt cctaacagga gtcactggct caggacccca gggagaaacg ctctccccac    960

ccacgccatg ctgaccagag atcttgcagc ccctgtggat gcccccgccg aggtcccccg   1020

atccccgcac ccggactgct gctccctgcc cctcccttgc gggtccccca ggaagccagg   1080

tgaccccagg tgggaggctg tgtgtggagg ccatcctgga aggaagttta gacctgccca   1140

ggtgtggagc gaggggcaca ggggcatcct aacctcagaa actgaaataa agcctttgaa   1200

aaaaaaatct gtaaaacatc aacccccaat cagaagatgg caaatgggga ataaaaatag   1260

caggtaacat gtccagcggg cccagtatct acattctggt gagcggcccg aggctgggag   1320

ctctgggcgg gggcagaccg gcggggcctt gcagcagggg tgggggtaaa gtgcgggtgg   1380

tggtggagag aacagggctg tggctggacc ccagcactgg tgacacgctg ggtgggagca   1440

tgaggcccca ggctgctgga ggtcctcgcc cggggaggtg gaggccgttc ctggtcaggg   1500

gcttcctgag gcccctgggg catgcagagg ccagggtttt agttaaaagt ttaatgtagt   1560

tcccaaatac atttcatatg acaatcttac ataaatgttc caaaacacaa aaa          1613


<210>  521
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  521


Met Asp Ala Val Asp Ala Thr Met Glu Lys Leu Arg Ala Gln Cys Leu 
1               5                   10                  15      


Ser Arg Gly Ala Ser Gly Ile Gln Gly Leu Ala Arg Phe Phe Arg Gln 
            20                  25                  30          


Leu Asp Arg Asp Gly Ser Arg Ser Leu Asp Ala Asp Glu Phe Arg Gln 
        35                  40                  45              


Gly Leu Ala Lys Leu Gly Leu Val Leu Asp Gln Ala Glu Ala Glu Gly 
    50                  55                  60                  


Val Cys Arg Lys Trp Asp Arg Asn Gly Ser Gly Thr Leu Asp Leu Glu 
65                  70                  75                  80  


Glu Phe Leu Arg Ala Leu Arg Pro Pro Met Ser Gln Ala Arg Glu Ala 
                85                  90                  95      


Val Ile Ala Ala Ala Phe Ala Lys Leu Asp Arg Ser Gly Asp Gly Val 
            100                 105                 110         


Val Thr Val Asp Asp Leu Arg Gly Val Tyr Ser Gly Arg Ala His Pro 
        115                 120                 125             


Lys Val Arg Ser Gly Glu Trp Thr Glu Asp Glu Val Leu Arg Arg Phe 
    130                 135                 140                 


Leu Asp Asn Phe Asp Ser Ser Glu Lys Asp Gly Gln Val Thr Leu Ala 
145                 150                 155                 160 


Glu Phe Gln Asp Tyr Tyr Ser Gly Val Ser Ala Ser Met Asn Thr Asp 
                165                 170                 175     


Glu Glu Phe Val Ala Met Met Thr Ser Ala Trp Gln Leu 
            180                 185                 

<210>  522
<211>  1532
<212>  DNA
<213>  Homo sapiens

<400>  522
acagtgcatt catgcagctg ggccccaccc catctccaga ggcaccttcc actagcaaca     60

gtctccccag gcacaacaca gctaacacaa ggccccgcag gcaggactct gggacagacg    120

caggccagct gcccagagcc cagaccaagc atggacgccg tggatgccac catggagaaa    180

ctccgggcac agtgcctgtc ccgcggggcc tcgggcatcc agggcctggc caggtttttc    240

cgccaactag accgggacgg gagcagatcc ctggacgctg atgagttccg gcagggtctg    300

gccaaactcg ggctggtgct ggaccaggcg gaggcagagg gtgtgtgcag gaagtgggac    360

cgcaatggca gcgggacgct ggatctggag gagttccttc gggcgctgcg gccccccatg    420

tcccaggccc gggaggctgt catcgcagct gcatttgcca agctggaccg cagtggggac    480

ggcgtcgtga cggtggacga cctccgcggg gtgtacagtg gccgtgccca ccccaaggtc    540

acactggcgg aattccagga ctactacagc ggcgtgagtg cctccatgaa cacggatgag    600

gagttcgtgg ccatgatgac cagtgcctgg cagctgtgag cagctccggc tcagccctgc    660

tgccctggcc tgtcactccc cacccctgcc ggagacctcc cttccctggg ccccttctct    720

cctgggcagc cacaccacag agcggggagg ggcaggtggg ggaatggagg ctgcaggact    780

ggctagacca ggtccctgcc ggtccaccag gcggaggtgg gacaaaggtc ctaacaggag    840

tcactggctc aggaccccag ggagaaacgc tctccccacc cacgccatgc tgaccagaga    900

tcttgcagcc cctgtggatg cccccgccga ggtcccccga tccccgcacc cggactgctg    960

ctccctgccc ctcccttgcg ggtcccccag gaagccaggt gaccccaggt gggaggctgt   1020

gtgtggaggc catcctggaa ggaagtttag acctgcccag gtgtggagcg aggggcacag   1080

gggcatccta acctcagaaa ctgaaataaa gcctttgaaa aaaaaatctg taaaacatca   1140

acccccaatc agaagatggc aaatggggaa taaaaatagc aggtaacatg tccagcgggc   1200

ccagtatcta cattctggtg agcggcccga ggctgggagc tctgggcggg ggcagaccgg   1260

cggggccttg cagcaggggt gggggtaaag tgcgggtggt ggtggagaga acagggctgt   1320

ggctggaccc cagcactggt gacacgctgg gtgggagcat gaggccccag gctgctggag   1380

gtcctcgccc ggggaggtgg aggccgttcc tggtcagggg cttcctgagg cccctggggc   1440

atgcagaggc cagggtttta gttaaaagtt taatgtagtt cccaaataca tttcatatga   1500

caatcttaca taaatgttcc aaaacacaaa aa                                 1532


<210>  523
<211>  162
<212>  PRT
<213>  Homo sapiens

<400>  523


Met Asp Ala Val Asp Ala Thr Met Glu Lys Leu Arg Ala Gln Cys Leu 
1               5                   10                  15      


Ser Arg Gly Ala Ser Gly Ile Gln Gly Leu Ala Arg Phe Phe Arg Gln 
            20                  25                  30          


Leu Asp Arg Asp Gly Ser Arg Ser Leu Asp Ala Asp Glu Phe Arg Gln 
        35                  40                  45              


Gly Leu Ala Lys Leu Gly Leu Val Leu Asp Gln Ala Glu Ala Glu Gly 
    50                  55                  60                  


Val Cys Arg Lys Trp Asp Arg Asn Gly Ser Gly Thr Leu Asp Leu Glu 
65                  70                  75                  80  


Glu Phe Leu Arg Ala Leu Arg Pro Pro Met Ser Gln Ala Arg Glu Ala 
                85                  90                  95      


Val Ile Ala Ala Ala Phe Ala Lys Leu Asp Arg Ser Gly Asp Gly Val 
            100                 105                 110         


Val Thr Val Asp Asp Leu Arg Gly Val Tyr Ser Gly Arg Ala His Pro 
        115                 120                 125             


Lys Val Thr Leu Ala Glu Phe Gln Asp Tyr Tyr Ser Gly Val Ser Ala 
    130                 135                 140                 


Ser Met Asn Thr Asp Glu Glu Phe Val Ala Met Met Thr Ser Ala Trp 
145                 150                 155                 160 


Gln Leu 
        

<210>  524
<211>  3400
<212>  DNA
<213>  Homo sapiens

<400>  524
agatggctcg tgcgcaggtg cgtgctagga gcgcggctcg tcagggcagg ctgctctgca     60

gggcaggcga tccggggctc gcctccgcgc ggcattcagc gcgcaggcgc gagctggccg    120

cctcacacgg agtcggcttg ttaagtgcgc acgcgcggga gtttctggca gaaagcaggc    180

gagcctgggc cggcgcgggg ccttgtggga gggcttaagg aagtaaaatg gcggacctgg    240

cgaacgaaga aaagcctgcc attgctccgc ccgtctttgt gtttcagaag gataaaggac    300

aaaagtcccc tgcagagcaa aaaaacttgt cggattcggg agaggagcct cggggggagg    360

ctgaggcccc ccaccatggc acgggtcacc ccgagtcagc tggcgagcat gccctagaac    420

ctcctgcccc tgctggcgcc tcagccagca ctcctccgcc tcccgctcct gaagcccagc    480

ttcctccttt tccgcgagaa ctggcaggga ggtcagctgg cggctccagt cctgaaggcg    540

gagaagattc tgacagagaa gatggaaatt actgccctcc tgtcaagcga gaaagaacat    600

cctctttaac ccagttccca ccctcacagt cagaggaaag gagcagtggc ttccggttga    660

agccaccaac gctgatccac ggccaagccc ccagcgcagg tctgccaagc cagaagccca    720

aggagcagca gcggagcgtg cttcgcccgg cagtgttaca agctccgcag ccaaaggcgc    780

tgtcccagac tgtccccagc agtggcacca acggggtcag cctcccagca gactgcacgg    840

gggcagtgcc cgcagcatcc cctgacactg ctgcatggag aagtccttcc gaagctgccg    900

atgaggagaa agagccccag aaaaatgagt ccagcaatgc ctctgaagag gaagcctgtg    960

agaaaaaaga ccccgccaca cagcaagcct ttgtatttgg gcagaacttg agggacagag   1020

ttaagctgat aaatgagagc gtggacgaag ccgacatgga gaatgctgga caccccagcg   1080

cagacacgcc aaccgcaacg aactatttcc tccagtatat cagttccagt ttagagaact   1140

caaccaatag tgccgacgcc tccagcaaca aatttgtatt tggccagaac atgagcgagc   1200

gagttttgag ccccccaaaa ttaaacgagg tcagttcaga tgccaacagg gaaaatgcag   1260

ctgccgagtc agggtctgag tcctcgtccc aggaggccac ccctgagaaa gagtccctgg   1320

ctgagtcggc agccgcctac accaaggcaa cagcgcggaa gtgtttgttg gaaaaagtgg   1380

aagtcatcac cggggaggag gcggagagca atgtgttaca gatgcagtgc aagctgtttg   1440

tctttgacaa gacctcacag tcctgggtgg agagaggccg ggggctgctc agactcaatg   1500

acatggcgtc caccgatgac ggcacactac agtcccgact agtgatgcgg acccagggga   1560

gcctgcgact gatcctcaac accaagctgt gggcccagat gcagatcgac aaggccagcg   1620

agaagagcat tcgcatcaca gccatggaca ccgaggacca gggcgtgaag gtcttcctga   1680

tctcggccag ctccaaggac acaggtcagt tgtatgcagc cctgcaccac cgcatcctgg   1740

ccctgcgcag ccgcgtggag caggagcagg aggccaagat gcccgcgcct gagcctgggg   1800

cagccccatc caacgaggag gacgacagcg acgatgacga tgtcctggct ccttcagggg   1860

ccaccgcagc tggtgctggt gacgaagggg acgggcagac gaccgggagc acatagcggc   1920

cgggagcccg gctgcacacc aggctgctgc tttgtccgtc tatccacccg cccacccgcc   1980

cccaccccac cggcagcgtc caggtgcggg gccgggaacc acacacccca ctgggccggc   2040

cacagtctgg acccgcacgt cctgttcaaa agcagactcg ggaactgcct gaatgtggtt   2100

tgggacacga gacctcatca tattgatgag cgaacaaaca agaacatttc ctccctcccc   2160

tcctttgaat tgaaatggca cattaagact tgtcacggct tctcactggg actggagacc   2220

tcgttccttc accccgcgtg tcgccagcct ctgggtccag ccagagcccc tggcttctcc   2280

gccacccaca cccttcccac cctgctgtgg ggccctgcct ttgtggggag cagccagccc   2340

tctgcccctg cccagggctc cccaactata ggcctgggac ccccgcccag cttggggggc   2400

tgctcgtacg agtgtagaca ctgggcccat tggacgtgct gttaactact atcttcattt   2460

cccacttccc ctctctgatt gggggtgtat attttacatc tttttttctt tttattttcg   2520

aaggctttgt tttggtttct taggttaaga tgctctcgag cgttgagcag gcacagctct   2580

gtcgaggtcc ctgtccccca cctgtggttc tggcctctga ggttggggga ctacttgttt   2640

cccaccccag gttcctccag gccaagtcat ggggtgatga ggagttgggg ccctgtctgt   2700

cctaggcctg gagagtgcct gtctgggaaa aggtcactgg acctggaagg gtccccaggg   2760

tcccctgact cccgtctcca tctgtcacgt ggttcaccat catcaggcac caggcgcaaa   2820

ctgcttcccg ctgttggcca tcccttcccc agccacaggt gtccctgccc ccaggacagt   2880

ccagggccag gggcttctgt gagaggcaga gggggaccct caccaaatct tggtggaaga   2940

gcccaggggc tggtcccaga acaggcagtc tcacaagcac gcagcacact ggagtggacg   3000

cctgtgccca cccgagcctg gagcatggcc aagagccagc ttgcaccacc cacctgggag   3060

gccgaggagg aggtcccctg ggcacagggc ctctttggga cttcagagga aatctcccag   3120

tcccactctc ggagggttaa gagaaggcct cctgcagctg tgccgtccac acctctaggt   3180

cgccagagcc ctggccccca gcccccagca agcctgagcc cgggaagaac cagaggccct   3240

cccgagagac ccagtcacac gtctctgctt taagccttag ccagctagtg acgagtacaa   3300

cgagataacg cccatgtgtt ttggaacatt tatgtaagat tgtcatatga aatgtatttg   3360

ggaactacat taaactttta actaaaaaaa aaaaaaaaaa                         3400


<210>  525
<211>  562
<212>  PRT
<213>  Homo sapiens

<400>  525


Met Ala Asp Leu Ala Asn Glu Glu Lys Pro Ala Ile Ala Pro Pro Val 
1               5                   10                  15      


Phe Val Phe Gln Lys Asp Lys Gly Gln Lys Ser Pro Ala Glu Gln Lys 
            20                  25                  30          


Asn Leu Ser Asp Ser Gly Glu Glu Pro Arg Gly Glu Ala Glu Ala Pro 
        35                  40                  45              


His His Gly Thr Gly His Pro Glu Ser Ala Gly Glu His Ala Leu Glu 
    50                  55                  60                  


Pro Pro Ala Pro Ala Gly Ala Ser Ala Ser Thr Pro Pro Pro Pro Ala 
65                  70                  75                  80  


Pro Glu Ala Gln Leu Pro Pro Phe Pro Arg Glu Leu Ala Gly Arg Ser 
                85                  90                  95      


Ala Gly Gly Ser Ser Pro Glu Gly Gly Glu Asp Ser Asp Arg Glu Asp 
            100                 105                 110         


Gly Asn Tyr Cys Pro Pro Val Lys Arg Glu Arg Thr Ser Ser Leu Thr 
        115                 120                 125             


Gln Phe Pro Pro Ser Gln Ser Glu Glu Arg Ser Ser Gly Phe Arg Leu 
    130                 135                 140                 


Lys Pro Pro Thr Leu Ile His Gly Gln Ala Pro Ser Ala Gly Leu Pro 
145                 150                 155                 160 


Ser Gln Lys Pro Lys Glu Gln Gln Arg Ser Val Leu Arg Pro Ala Val 
                165                 170                 175     


Leu Gln Ala Pro Gln Pro Lys Ala Leu Ser Gln Thr Val Pro Ser Ser 
            180                 185                 190         


Gly Thr Asn Gly Val Ser Leu Pro Ala Asp Cys Thr Gly Ala Val Pro 
        195                 200                 205             


Ala Ala Ser Pro Asp Thr Ala Ala Trp Arg Ser Pro Ser Glu Ala Ala 
    210                 215                 220                 


Asp Glu Glu Lys Glu Pro Gln Lys Asn Glu Ser Ser Asn Ala Ser Glu 
225                 230                 235                 240 


Glu Glu Ala Cys Glu Lys Lys Asp Pro Ala Thr Gln Gln Ala Phe Val 
                245                 250                 255     


Phe Gly Gln Asn Leu Arg Asp Arg Val Lys Leu Ile Asn Glu Ser Val 
            260                 265                 270         


Asp Glu Ala Asp Met Glu Asn Ala Gly His Pro Ser Ala Asp Thr Pro 
        275                 280                 285             


Thr Ala Thr Asn Tyr Phe Leu Gln Tyr Ile Ser Ser Ser Leu Glu Asn 
    290                 295                 300                 


Ser Thr Asn Ser Ala Asp Ala Ser Ser Asn Lys Phe Val Phe Gly Gln 
305                 310                 315                 320 


Asn Met Ser Glu Arg Val Leu Ser Pro Pro Lys Leu Asn Glu Val Ser 
                325                 330                 335     


Ser Asp Ala Asn Arg Glu Asn Ala Ala Ala Glu Ser Gly Ser Glu Ser 
            340                 345                 350         


Ser Ser Gln Glu Ala Thr Pro Glu Lys Glu Ser Leu Ala Glu Ser Ala 
        355                 360                 365             


Ala Ala Tyr Thr Lys Ala Thr Ala Arg Lys Cys Leu Leu Glu Lys Val 
    370                 375                 380                 


Glu Val Ile Thr Gly Glu Glu Ala Glu Ser Asn Val Leu Gln Met Gln 
385                 390                 395                 400 


Cys Lys Leu Phe Val Phe Asp Lys Thr Ser Gln Ser Trp Val Glu Arg 
                405                 410                 415     


Gly Arg Gly Leu Leu Arg Leu Asn Asp Met Ala Ser Thr Asp Asp Gly 
            420                 425                 430         


Thr Leu Gln Ser Arg Leu Val Met Arg Thr Gln Gly Ser Leu Arg Leu 
        435                 440                 445             


Ile Leu Asn Thr Lys Leu Trp Ala Gln Met Gln Ile Asp Lys Ala Ser 
    450                 455                 460                 


Glu Lys Ser Ile Arg Ile Thr Ala Met Asp Thr Glu Asp Gln Gly Val 
465                 470                 475                 480 


Lys Val Phe Leu Ile Ser Ala Ser Ser Lys Asp Thr Gly Gln Leu Tyr 
                485                 490                 495     


Ala Ala Leu His His Arg Ile Leu Ala Leu Arg Ser Arg Val Glu Gln 
            500                 505                 510         


Glu Gln Glu Ala Lys Met Pro Ala Pro Glu Pro Gly Ala Ala Pro Ser 
        515                 520                 525             


Asn Glu Glu Asp Asp Ser Asp Asp Asp Asp Val Leu Ala Pro Ser Gly 
    530                 535                 540                 


Ala Thr Ala Ala Gly Ala Gly Asp Glu Gly Asp Gly Gln Thr Thr Gly 
545                 550                 555                 560 


Ser Thr 
        

<210>  526
<211>  3211
<212>  DNA
<213>  Homo sapiens

<400>  526
agatggctcg tgcgcaggtg cgtgctagga gcgcggctcg tcagggcagg ctgctctgca     60

gggcaggcga tccggggctc gcctccgcgc ggcattcagc gcgcaggcgc gagctggccg    120

cctcacacgg agtcggcttg ttaagtgcgc acgcgcggga gtttctggca gaaagcaggc    180

gagcctgggc cggcgcgggg ccttgtggga gggcttaagg aagtaaaatg gcggacctgg    240

cgaacgaaga aaagcctgcc attgctccgc ccgtctttgt gtttcagaag gataaaggac    300

aaaagaggtc agctggcggc tccagtcctg aaggcggaga agattctgac agagaagatg    360

gaaattactg ccctcctgtc aagcgagaaa gaacatcctc tttaacccag ttcccaccct    420

cacagtcaga ggaaaggagc agtggcttcc ggttgaagcc accaacgctg atccacggcc    480

aagcccccag cgcaggtctg ccaagccaga agcccaagga gcagcagcgg agcgtgcttc    540

gcccggcagt gttacaagct ccgcagccaa aggcgctgtc ccagactgtc cccagcagtg    600

gcaccaacgg ggtcagcctc ccagcagact gcacgggggc agtgcccgca gcatcccctg    660

acactgctgc atggagaagt ccttccgaag ctgccgatga ggtgtgtgca cttgaggaga    720

aagagcccca gaaaaatgag tccagcaatg cctctgaaga ggaagcctgt gagaaaaaag    780

accccgccac acagcaagcc tttgtatttg ggcagaactt gagggacaga gttaagctga    840

taaatgagag cgtggacgaa gccgacatgg agaatgctgg acaccccagc gcagacacgc    900

caaccgcaac gaactatttc ctccagtata tcagttccag tttagagaac tcaaccaata    960

gtgccgacgc ctccagcaac aaatttgtat ttggccagaa catgagcgag cgagttttga   1020

gccccccaaa attaaacgag gtcagttcag atgccaacag ggaaaatgca gctgccgagt   1080

cagggtctga gtcctcgtcc caggaggcca cccctgagaa agagtccctg gctgagtcgg   1140

cagccgccta caccaaggca acagcgcgga agtgtttgtt ggaaaaagtg gaagtcatca   1200

ccggggagga ggcggagagc aatgtgttac agatgcagtg caagctgttt gtctttgaca   1260

agacctcaca gtcctgggtg gagagaggcc gggggctgct cagactcaat gacatggcgt   1320

ccaccgatga cggcacacta cagtcccgac tagtgatgcg gacccagggg agcctgcgac   1380

tgatcctcaa caccaagctg tgggcccaga tgcagatcga caaggccagc gagaagagca   1440

ttcgcatcac agccatggac accgaggacc agggcgtgaa ggtcttcctg atctcggcca   1500

gctccaagga cacaggtcag ttgtatgcag ccctgcacca ccgcatcctg gccctgcgca   1560

gccgcgtgga gcaggagcag gaggccaaga tgcccgcgcc tgagcctggg gcagccccat   1620

ccaacgagga ggacgacagc gacgatgacg atgtcctggc tccttcaggg gccaccgcag   1680

ctggtgctgg tgacgaaggg gacgggcaga cgaccgggag cacatagcgg ccgggagccc   1740

ggctgcacac caggctgctg ctttgtccgt ctatccaccc gcccacccgc ccccacccca   1800

ccggcagcgt ccaggtgcgg ggccgggaac cacacacccc actgggccgg ccacagtctg   1860

gacccgcacg tcctgttcaa aagcagactc gggaactgcc tgaatgtggt ttgggacacg   1920

agacctcatc atattgatga gcgaacaaac aagaacattt cctccctccc ctcctttgaa   1980

ttgaaatggc acattaagac ttgtcacggc ttctcactgg gactggagac ctcgttcctt   2040

caccccgcgt gtcgccagcc tctgggtcca gccagagccc ctggcttctc cgccacccac   2100

acccttccca ccctgctgtg gggccctgcc tttgtgggga gcagccagcc ctctgcccct   2160

gcccagggct ccccaactat aggcctggga cccccgccca gcttgggggg ctgctcgtac   2220

gagtgtagac actgggccca ttggacgtgc tgttaactac tatcttcatt tcccacttcc   2280

cctctctgat tgggggtgta tattttacat ctttttttct ttttattttc gaaggctttg   2340

ttttggtttc ttaggttaag atgctctcga gcgttgagca ggcacagctc tgtcgaggtc   2400

cctgtccccc acctgtggtt ctggcctctg aggttggggg actacttgtt tcccacccca   2460

ggttcctcca ggccaagtca tggggtgatg aggagttggg gccctgtctg tcctaggcct   2520

ggagagtgcc tgtctgggaa aaggtcactg gacctggaag ggtccccagg gtcccctgac   2580

tcccgtctcc atctgtcacg tggttcacca tcatcaggca ccaggcgcaa actgcttccc   2640

gctgttggcc atcccttccc cagccacagg tgtccctgcc cccaggacag tccagggcca   2700

ggggcttctg tgagaggcag agggggaccc tcaccaaatc ttggtggaag agcccagggg   2760

ctggtcccag aacaggcagt ctcacaagca cgcagcacac tggagtggac gcctgtgccc   2820

acccgagcct ggagcatggc caagagccag cttgcaccac ccacctggga ggccgaggag   2880

gaggtcccct gggcacaggg cctctttggg acttcagagg aaatctccca gtcccactct   2940

cggagggtta agagaaggcc tcctgcagct gtgccgtcca cacctctagg tcgccagagc   3000

cctggccccc agcccccagc aagcctgagc ccgggaagaa ccagaggccc tcccgagaga   3060

cccagtcaca cgtctctgct ttaagcctta gccagctagt gacgagtaca acgagataac   3120

gcccatgtgt tttggaacat ttatgtaaga ttgtcatatg aaatgtattt gggaactaca   3180

ttaaactttt aactaaaaaa aaaaaaaaaa a                                  3211


<210>  527
<211>  499
<212>  PRT
<213>  Homo sapiens

<400>  527


Met Ala Asp Leu Ala Asn Glu Glu Lys Pro Ala Ile Ala Pro Pro Val 
1               5                   10                  15      


Phe Val Phe Gln Lys Asp Lys Gly Gln Lys Arg Ser Ala Gly Gly Ser 
            20                  25                  30          


Ser Pro Glu Gly Gly Glu Asp Ser Asp Arg Glu Asp Gly Asn Tyr Cys 
        35                  40                  45              


Pro Pro Val Lys Arg Glu Arg Thr Ser Ser Leu Thr Gln Phe Pro Pro 
    50                  55                  60                  


Ser Gln Ser Glu Glu Arg Ser Ser Gly Phe Arg Leu Lys Pro Pro Thr 
65                  70                  75                  80  


Leu Ile His Gly Gln Ala Pro Ser Ala Gly Leu Pro Ser Gln Lys Pro 
                85                  90                  95      


Lys Glu Gln Gln Arg Ser Val Leu Arg Pro Ala Val Leu Gln Ala Pro 
            100                 105                 110         


Gln Pro Lys Ala Leu Ser Gln Thr Val Pro Ser Ser Gly Thr Asn Gly 
        115                 120                 125             


Val Ser Leu Pro Ala Asp Cys Thr Gly Ala Val Pro Ala Ala Ser Pro 
    130                 135                 140                 


Asp Thr Ala Ala Trp Arg Ser Pro Ser Glu Ala Ala Asp Glu Val Cys 
145                 150                 155                 160 


Ala Leu Glu Glu Lys Glu Pro Gln Lys Asn Glu Ser Ser Asn Ala Ser 
                165                 170                 175     


Glu Glu Glu Ala Cys Glu Lys Lys Asp Pro Ala Thr Gln Gln Ala Phe 
            180                 185                 190         


Val Phe Gly Gln Asn Leu Arg Asp Arg Val Lys Leu Ile Asn Glu Ser 
        195                 200                 205             


Val Asp Glu Ala Asp Met Glu Asn Ala Gly His Pro Ser Ala Asp Thr 
    210                 215                 220                 


Pro Thr Ala Thr Asn Tyr Phe Leu Gln Tyr Ile Ser Ser Ser Leu Glu 
225                 230                 235                 240 


Asn Ser Thr Asn Ser Ala Asp Ala Ser Ser Asn Lys Phe Val Phe Gly 
                245                 250                 255     


Gln Asn Met Ser Glu Arg Val Leu Ser Pro Pro Lys Leu Asn Glu Val 
            260                 265                 270         


Ser Ser Asp Ala Asn Arg Glu Asn Ala Ala Ala Glu Ser Gly Ser Glu 
        275                 280                 285             


Ser Ser Ser Gln Glu Ala Thr Pro Glu Lys Glu Ser Leu Ala Glu Ser 
    290                 295                 300                 


Ala Ala Ala Tyr Thr Lys Ala Thr Ala Arg Lys Cys Leu Leu Glu Lys 
305                 310                 315                 320 


Val Glu Val Ile Thr Gly Glu Glu Ala Glu Ser Asn Val Leu Gln Met 
                325                 330                 335     


Gln Cys Lys Leu Phe Val Phe Asp Lys Thr Ser Gln Ser Trp Val Glu 
            340                 345                 350         


Arg Gly Arg Gly Leu Leu Arg Leu Asn Asp Met Ala Ser Thr Asp Asp 
        355                 360                 365             


Gly Thr Leu Gln Ser Arg Leu Val Met Arg Thr Gln Gly Ser Leu Arg 
    370                 375                 380                 


Leu Ile Leu Asn Thr Lys Leu Trp Ala Gln Met Gln Ile Asp Lys Ala 
385                 390                 395                 400 


Ser Glu Lys Ser Ile Arg Ile Thr Ala Met Asp Thr Glu Asp Gln Gly 
                405                 410                 415     


Val Lys Val Phe Leu Ile Ser Ala Ser Ser Lys Asp Thr Gly Gln Leu 
            420                 425                 430         


Tyr Ala Ala Leu His His Arg Ile Leu Ala Leu Arg Ser Arg Val Glu 
        435                 440                 445             


Gln Glu Gln Glu Ala Lys Met Pro Ala Pro Glu Pro Gly Ala Ala Pro 
    450                 455                 460                 


Ser Asn Glu Glu Asp Asp Ser Asp Asp Asp Asp Val Leu Ala Pro Ser 
465                 470                 475                 480 


Gly Ala Thr Ala Ala Gly Ala Gly Asp Glu Gly Asp Gly Gln Thr Thr 
                485                 490                 495     


Gly Ser Thr 
            

<210>  528
<211>  3415
<212>  DNA
<213>  Homo sapiens

<400>  528
agatggctcg tgcgcaggtg cgtgctagga gcgcggctcg tcagggcagg ctgctctgca     60

gggcaggcga tccggggctc gcctccgcgc ggcattcagc gcgcaggcgc gagctggccg    120

cctcacacgg agtcggcttg ttaagtgcgc acgcgcggga gtttctggca gaaagcaggc    180

gagcctgggc cggcgcgggg ccttgtggga gggcttaagg aagtaaaatg gcggacctgg    240

cgaacgaaga aaagcctgcc attgctccgc ccgtctttgt gtttcagaag gataaaggac    300

aaaagtcccc tgcagagcaa aaaaacttgt cggattcggg agaggagcct cggggggagg    360

ctgaggcccc ccaccatggc acgggtcacc ccgagtcagc tggcgagcat gccctagaac    420

ctcctgcccc tgctggcgcc tcagccagca ctcctccgcc tcccgctcct gaagcccagc    480

ttcctccttt tccgcgagaa ctggcaggga ggtcagctgg cggctccagt cctgaaggcg    540

gagaagattc tgacagagaa gatggaaatt actgccctcc tgtcaagcga gaaagaacat    600

cctctttaac ccagttccca ccctcacagt cagaggaaag gagcagtggc ttccggttga    660

agccaccaac gctgatccac ggccaagccc ccagcgcagg tctgccaagc cagaagccca    720

aggagcagca gcggagcgtg cttcgcccgg cagtgttaca agctccgcag ccaaaggcgc    780

tgtcccagac tgtccccagc agtggcacca acggggtcag cctcccagca gactgcacgg    840

gggcagtgcc cgcagcatcc cctgacactg ctgcatggag aagtccttcc gaagctgccg    900

atgaggtgtg tgcacttgag gagaaagagc cccagaaaaa tgagtccagc aatgcctctg    960

aagaggaagc ctgtgagaaa aaagaccccg ccacacagca agcctttgta tttgggcaga   1020

acttgaggga cagagttaag ctgataaatg agagcgtgga cgaagccgac atggagaatg   1080

ctggacaccc cagcgcagac acgccaaccg caacgaacta tttcctccag tatatcagtt   1140

ccagtttaga gaactcaacc aatagtgccg acgcctccag caacaaattt gtatttggcc   1200

agaacatgag cgagcgagtt ttgagccccc caaaattaaa cgaggtcagt tcagatgcca   1260

acagggaaaa tgcagctgcc gagtcagggt ctgagtcctc gtcccaggag gccacccctg   1320

agaaagagtc cctggctgag tcggcagccg cctacaccaa ggcaacagcg cggaagtgtt   1380

tgttggaaaa agtggaagtc atcaccgggg aggaggcgga gagcaatgtg ttacagatgc   1440

agtgcaagct gtttgtcttt gacaagacct cacagtcctg ggtggagaga ggccgggggc   1500

tgctcagact caatgacatg gcgtccaccg atgacggcac actacagtcc cgactagtga   1560

tgcggaccca ggggagcctg cgactgatcc tcaacaccaa gctgtgggcc cagatgcaga   1620

tcgacaaggc cagcgagaag agcattcgca tcacagccat ggacaccgag gaccagggcg   1680

tgaaggtctt cctgatctcg gccagctcca aggacacagg tcagttgtat gcagccctgc   1740

accaccgcat cctggccctg cgcagccgcg tggagcagga gcaggaggcc aagatgcccg   1800

cgcctgagcc tggggcagcc ccatccaacg aggaggacga cagcgacgat gacgatgtcc   1860

tggctccttc aggggccacc gcagctggtg ctggtgacga aggggacggg cagacgaccg   1920

ggagcacata gcggccggga gcccggctgc acaccaggct gctgctttgt ccgtctatcc   1980

acccgcccac ccgcccccac cccaccggca gcgtccaggt gcggggccgg gaaccacaca   2040

ccccactggg ccggccacag tctggacccg cacgtcctgt tcaaaagcag actcgggaac   2100

tgcctgaatg tggtttggga cacgagacct catcatattg atgagcgaac aaacaagaac   2160

atttcctccc tcccctcctt tgaattgaaa tggcacatta agacttgtca cggcttctca   2220

ctgggactgg agacctcgtt ccttcacccc gcgtgtcgcc agcctctggg tccagccaga   2280

gcccctggct tctccgccac ccacaccctt cccaccctgc tgtggggccc tgcctttgtg   2340

gggagcagcc agccctctgc ccctgcccag ggctccccaa ctataggcct gggacccccg   2400

cccagcttgg ggggctgctc gtacgagtgt agacactggg cccattggac gtgctgttaa   2460

ctactatctt catttcccac ttcccctctc tgattggggg tgtatatttt acatcttttt   2520

ttctttttat tttcgaaggc tttgttttgg tttcttaggt taagatgctc tcgagcgttg   2580

agcaggcaca gctctgtcga ggtccctgtc ccccacctgt ggttctggcc tctgaggttg   2640

ggggactact tgtttcccac cccaggttcc tccaggccaa gtcatggggt gatgaggagt   2700

tggggccctg tctgtcctag gcctggagag tgcctgtctg ggaaaaggtc actggacctg   2760

gaagggtccc cagggtcccc tgactcccgt ctccatctgt cacgtggttc accatcatca   2820

ggcaccaggc gcaaactgct tcccgctgtt ggccatccct tccccagcca caggtgtccc   2880

tgcccccagg acagtccagg gccaggggct tctgtgagag gcagaggggg accctcacca   2940

aatcttggtg gaagagccca ggggctggtc ccagaacagg cagtctcaca agcacgcagc   3000

acactggagt ggacgcctgt gcccacccga gcctggagca tggccaagag ccagcttgca   3060

ccacccacct gggaggccga ggaggaggtc ccctgggcac agggcctctt tgggacttca   3120

gaggaaatct cccagtccca ctctcggagg gttaagagaa ggcctcctgc agctgtgccg   3180

tccacacctc taggtcgcca gagccctggc ccccagcccc cagcaagcct gagcccggga   3240

agaaccagag gccctcccga gagacccagt cacacgtctc tgctttaagc cttagccagc   3300

tagtgacgag tacaacgaga taacgcccat gtgttttgga acatttatgt aagattgtca   3360

tatgaaatgt atttgggaac tacattaaac ttttaactaa aaaaaaaaaa aaaaa        3415


<210>  529
<211>  567
<212>  PRT
<213>  Homo sapiens

<400>  529


Met Ala Asp Leu Ala Asn Glu Glu Lys Pro Ala Ile Ala Pro Pro Val 
1               5                   10                  15      


Phe Val Phe Gln Lys Asp Lys Gly Gln Lys Ser Pro Ala Glu Gln Lys 
            20                  25                  30          


Asn Leu Ser Asp Ser Gly Glu Glu Pro Arg Gly Glu Ala Glu Ala Pro 
        35                  40                  45              


His His Gly Thr Gly His Pro Glu Ser Ala Gly Glu His Ala Leu Glu 
    50                  55                  60                  


Pro Pro Ala Pro Ala Gly Ala Ser Ala Ser Thr Pro Pro Pro Pro Ala 
65                  70                  75                  80  


Pro Glu Ala Gln Leu Pro Pro Phe Pro Arg Glu Leu Ala Gly Arg Ser 
                85                  90                  95      


Ala Gly Gly Ser Ser Pro Glu Gly Gly Glu Asp Ser Asp Arg Glu Asp 
            100                 105                 110         


Gly Asn Tyr Cys Pro Pro Val Lys Arg Glu Arg Thr Ser Ser Leu Thr 
        115                 120                 125             


Gln Phe Pro Pro Ser Gln Ser Glu Glu Arg Ser Ser Gly Phe Arg Leu 
    130                 135                 140                 


Lys Pro Pro Thr Leu Ile His Gly Gln Ala Pro Ser Ala Gly Leu Pro 
145                 150                 155                 160 


Ser Gln Lys Pro Lys Glu Gln Gln Arg Ser Val Leu Arg Pro Ala Val 
                165                 170                 175     


Leu Gln Ala Pro Gln Pro Lys Ala Leu Ser Gln Thr Val Pro Ser Ser 
            180                 185                 190         


Gly Thr Asn Gly Val Ser Leu Pro Ala Asp Cys Thr Gly Ala Val Pro 
        195                 200                 205             


Ala Ala Ser Pro Asp Thr Ala Ala Trp Arg Ser Pro Ser Glu Ala Ala 
    210                 215                 220                 


Asp Glu Val Cys Ala Leu Glu Glu Lys Glu Pro Gln Lys Asn Glu Ser 
225                 230                 235                 240 


Ser Asn Ala Ser Glu Glu Glu Ala Cys Glu Lys Lys Asp Pro Ala Thr 
                245                 250                 255     


Gln Gln Ala Phe Val Phe Gly Gln Asn Leu Arg Asp Arg Val Lys Leu 
            260                 265                 270         


Ile Asn Glu Ser Val Asp Glu Ala Asp Met Glu Asn Ala Gly His Pro 
        275                 280                 285             


Ser Ala Asp Thr Pro Thr Ala Thr Asn Tyr Phe Leu Gln Tyr Ile Ser 
    290                 295                 300                 


Ser Ser Leu Glu Asn Ser Thr Asn Ser Ala Asp Ala Ser Ser Asn Lys 
305                 310                 315                 320 


Phe Val Phe Gly Gln Asn Met Ser Glu Arg Val Leu Ser Pro Pro Lys 
                325                 330                 335     


Leu Asn Glu Val Ser Ser Asp Ala Asn Arg Glu Asn Ala Ala Ala Glu 
            340                 345                 350         


Ser Gly Ser Glu Ser Ser Ser Gln Glu Ala Thr Pro Glu Lys Glu Ser 
        355                 360                 365             


Leu Ala Glu Ser Ala Ala Ala Tyr Thr Lys Ala Thr Ala Arg Lys Cys 
    370                 375                 380                 


Leu Leu Glu Lys Val Glu Val Ile Thr Gly Glu Glu Ala Glu Ser Asn 
385                 390                 395                 400 


Val Leu Gln Met Gln Cys Lys Leu Phe Val Phe Asp Lys Thr Ser Gln 
                405                 410                 415     


Ser Trp Val Glu Arg Gly Arg Gly Leu Leu Arg Leu Asn Asp Met Ala 
            420                 425                 430         


Ser Thr Asp Asp Gly Thr Leu Gln Ser Arg Leu Val Met Arg Thr Gln 
        435                 440                 445             


Gly Ser Leu Arg Leu Ile Leu Asn Thr Lys Leu Trp Ala Gln Met Gln 
    450                 455                 460                 


Ile Asp Lys Ala Ser Glu Lys Ser Ile Arg Ile Thr Ala Met Asp Thr 
465                 470                 475                 480 


Glu Asp Gln Gly Val Lys Val Phe Leu Ile Ser Ala Ser Ser Lys Asp 
                485                 490                 495     


Thr Gly Gln Leu Tyr Ala Ala Leu His His Arg Ile Leu Ala Leu Arg 
            500                 505                 510         


Ser Arg Val Glu Gln Glu Gln Glu Ala Lys Met Pro Ala Pro Glu Pro 
        515                 520                 525             


Gly Ala Ala Pro Ser Asn Glu Glu Asp Asp Ser Asp Asp Asp Asp Val 
    530                 535                 540                 


Leu Ala Pro Ser Gly Ala Thr Ala Ala Gly Ala Gly Asp Glu Gly Asp 
545                 550                 555                 560 


Gly Gln Thr Thr Gly Ser Thr 
                565         

<210>  530
<211>  639
<212>  DNA
<213>  Homo sapiens

<400>  530
cgcgcggccc gaggcgggtc ttgaagcact cgttttccca ctcgttttcc ggggttcccc     60

cgcggtggga cagtgagcag ttcagggcgc cgcagccgag gccttcctcc aggaaaggtt    120

tgctggctcc tgccttagaa gatgagaaag tttgtgatgg atggagaaga ggatcttcca    180

gaaaataacc agggctttcc agccactgga tccaaagact atgctctccc tgagggtgga    240

gacggagcca ggtttgccca tgtgagcatc tgcaggatcc tggagatgtc tcaagcctgg    300

cagcagagaa agactgtcca aggaggcagc aggagccaag gccagtgaca ccacatctca    360

aggagccaaa tgacgatgcg gattttcagg ctaaaactgt gaggccagat tttgcgggcg    420

gtgagctgga aggagcactg gactaggagt cctgagaggt tagagtataa gactccatcc    480

accaggagga catactggct cacacataaa aagaaagttt tggaacagat gatccttctg    540

ctgtttaccc ccgaaccccc aggctattta agagtagaat cctttgcttg ggtaattacg    600

ttgacattga cactaaaagg atgcatagtt gtcttgaca                           639


<210>  531
<211>  68
<212>  PRT
<213>  Homo sapiens

<400>  531


Met Arg Lys Phe Val Met Asp Gly Glu Glu Asp Leu Pro Glu Asn Asn 
1               5                   10                  15      


Gln Gly Phe Pro Ala Thr Gly Ser Lys Asp Tyr Ala Leu Pro Glu Gly 
            20                  25                  30          


Gly Asp Gly Ala Arg Phe Ala His Val Ser Ile Cys Arg Ile Leu Glu 
        35                  40                  45              


Met Ser Gln Ala Trp Gln Gln Arg Lys Thr Val Gln Gly Gly Ser Arg 
    50                  55                  60                  


Ser Gln Gly Gln 
65              

<210>  532
<211>  4114
<212>  DNA
<213>  Homo sapiens

<400>  532
gcgagcgtgg gcgggccgtt aggaaggtgg ggcgcggagc ctggtaaccg ttgccggtaa     60

caacgccccg ccccgtcggg cgggcgggct gcgcgaggct ggctggcggc gggagccgga    120

ggaggagcgg ccgccgccgc caccgccgcc gccatagaga ctgtagccgt ggagactgtt    180

acttaccaac ggggaccaac acgcagcagc cgctgccgcc gccgcgggag ccgctgcccg    240

aactcccggc ccgaactcca gacctgagca tgcagaattc cgagggtgga gcggattcgc    300

cagcgtccgt ggctctgcgt ccctcggcgg cagccccgcc tgtgccagcc tccccgcaga    360

gggtgttggt ccaggcagcc agctccaatc ccaaaggggc ccagatgcag ccgatctccc    420

tccccagagt tcagcaggta ccccagcagg tgcagccggt gcagcacgtg tatcctgccc    480

aggtgcagta cgtggaaggg ggagacgccg tctacaccaa tggagccata cgaacagcct    540

acacctacaa ccccgagcct cagatgtacg cccccagcag cacggcttct tacttcgagg    600

ccccaggcgg tgcccaggtg accgtggcag cctcgtcccc gccagcggtc ccctcccaca    660

gcatggtggg catcaccatg gatgtcgggg ggagccccat cgtctccagc gcgggagcct    720

atctcatcca cggggggatg gacagcacca gacactccct ggcccacacc tcccgctcat    780

cgcccgccac gcttgaaatg gcgattgaaa acctccaaaa aagcgaagga atcacatcac    840

acaaaagcgg tttactcaac agccatctcc agtggctgtt ggataattat gaaacagcgg    900

aaggtgtgag tctccccaga agttctcttt acaaccacta ccttcggcac tgccaggagc    960

acaagctaga cccagtgaac gccgcctcct tcgggaaact gatccgttct gtgtttatgg   1020

ggctgagaac gcggcggctg ggcaccaggg gcaactcgaa gtaccattac tatgggattc   1080

gtctgaagcc ggactcacca ctgaaccggc tgcaggagga cacgcagtac atggccatgc   1140

ggcagcagcc catgcaccag aagcccaggt accggccagc ccagaagacg gacagcctcg   1200

gggacagcgg ctcccacagc ggcctgcaca gcactccgga acagaccatg gccgtgcaga   1260

gccagcacca ccagcagtac atagatgtct cccacgtctt ccccgagttc ccagcgcccg   1320

acctgggcag cttcctgctg caggacggcg tcacactgca cgacgtcaag gccctgcagc   1380

tggtgtacag acggcactgc gaggcaactg tagatgtggt gatgaacctc cagttccact   1440

acatcgagaa gctgtggctc tccttctgga actctaaggc ctcctccagc gacggcccca   1500

cctctcttcc tgccagtgac gaagaccccg agggcgccgt cctgcccaag gacaagctta   1560

tctccctgtg tcagtgcgac cccatcctca ggtggatgag gagctgcgac cacatcctct   1620

accaggcgct ggtggagatt ctcatccccg acgtgctgag gccggtcccc agtaccttga   1680

cacaggccat ccgtaacttt gccaagagct tggaaggctg gttgacaaat gccatgagtg   1740

acttcccaca acaggtcatc cagaccaagg tgggcgtcgt cagtgccttc gcccagacgc   1800

tgcggcgcta cacgtccctc aaccacctgg cgcaggcggc ccgggcggtg ctgcagaaca   1860

cgtcccagat caaccagatg ctcagcgacc tcaaccgcgt ggactttgcc aacgtgcagg   1920

agcaggcctc gtgggtgtgc cagtgcgagg agagtgtggt gcagcggctg gagcaggatt   1980

tcaagctgac cctgcagcag cagagctccc tggaccagtg ggccagctgg ctggacagtg   2040

tggtcaccca ggtcctgaag cagcatgccg gcagccccag cttccccaag gccgcccggc   2100

agttcttgct gaaatggtcc ttttacagct ccatggtgat ccgggacctg accctgcgca   2160

gcgctgccag cttcggctcc ttccacctca tccgcctgct ctacgacgag tacatgttct   2220

acctggtgga gcaccgcgtc gcggaggcca ccggagagac gccgatcgct gtgatgggag   2280

agttcaacga tctcgcctct ctgtcgctga cgctgctcga caaagatgac atgggcgatg   2340

agcagcgtgg cagcgaggcg ggcccagacg cccgcagcct gggtgagccc ctggtaaagc   2400

gggagcgcag tgaccccaac cactccctgc agggcatcta gcagccccgg ccggcgcctc   2460

ctcgaggttc caaaagatgc cgcctggtca ctctgggaac ctggatttca ccggctccac   2520

caaattagtg cctcttagat gatgtgatgt ttactttgac tcaagcgggg gctcccgggg   2580

tcagtgttca agaaggaaag cagttgttga agctacagaa gcccaggcca gggctcccac   2640

tggctgtagc tgtgctctgg gtccccaggt ccctgcgcag ccaccagggc cccaccagac   2700

catgggttcc ttattctgga caaaccctcc tctgctggaa ccctggactt tggccccagt   2760

ccctttaaga gctgaaaggg ctgtgctgag agcactggcc tctgcactca actggaacca   2820

attttcacca tgattttaaa aattaaaaaa acctggcaga gcccgactag aaagggacgg   2880

cctctcccct cctacctgcc accgctgggg aggcacagag ctcgccagcg tccctggagt   2940

cccctcagga atggaaagtg gagtgccctt gtctggtagc accatgtggg agggacccag   3000

ctgggcgcag cgccctgtgg ccttttagat ccagacctcc ctgccggatg ccccgaggcg   3060

ggaggccggc tgtgctgcag gaacccatct ccagatgcca aaggacttga ggggcagctg   3120

acaatcgctg tgtcccggca gatccgcagc tcgaaaaaga acaagccaca gaaacgggct   3180

cgctcgtgcc aggacacagc agtgtctttc aaaaaatcaa aaccagaagt tttatcagca   3240

gcaggaagga tgtgggactc tgtccaagtt caccgtcacc atcaagccac tggctgtgga   3300

aggagtttgt ccaacagggt cagtgtcaca gccacaactt cagaaagcag ccatcccgcg   3360

tgtcgtccaa acagcagtgc ctgcgtcccg ctccacggag tcttccagaa cacctccctc   3420

tgaactaatc ccggagcacc ccacccccag cgagtcccac ctggacctct tcaaagtcaa   3480

aactcttctc tcgggacaaa caaatattcg ggactttcga agccctgaac ttgagacacc   3540

aagtttgtct ccatggaaac acgtagccgc tgcagttgga cagctgcgtg ctggagttct   3600

gtccccaaac caactgcaga gaagaaagac gagcctcggc ccaggacgcg atttctaacg   3660

aaatgcaata gttttctctt tttggaaaaa tgtttatacc aatagttttg tgcgctaatt   3720

gttattagaa cgtttcttat gaatgtgtac attgcagtat attcagtccc aaatgttttg   3780

ttctcattca cacagaaggt actaatgtca gctcacgtgg cctttaaaaa cctacttccc   3840

cgcccgcagg agctcagagc atcgctgggc ctgcgccaga gtgaggggtg caggaagaca   3900

aagacgcgtg ctcactttag aaacgaaaag ctgggaataa tcacactgtt tgtctggtcg   3960

tatagcccaa accttagttg aaatcagaca gaaagaatgt ctttaaaata tacatctcct   4020

ctccttggag acactgaagc tcacagttaa cggattgtaa tgcccggctt ttcctcactc   4080

ctggtaacca atacaagctg gtttctgcct taaa                               4114


<210>  533
<211>  723
<212>  PRT
<213>  Homo sapiens

<400>  533


Met Gln Asn Ser Glu Gly Gly Ala Asp Ser Pro Ala Ser Val Ala Leu 
1               5                   10                  15      


Arg Pro Ser Ala Ala Ala Pro Pro Val Pro Ala Ser Pro Gln Arg Val 
            20                  25                  30          


Leu Val Gln Ala Ala Ser Ser Asn Pro Lys Gly Ala Gln Met Gln Pro 
        35                  40                  45              


Ile Ser Leu Pro Arg Val Gln Gln Val Pro Gln Gln Val Gln Pro Val 
    50                  55                  60                  


Gln His Val Tyr Pro Ala Gln Val Gln Tyr Val Glu Gly Gly Asp Ala 
65                  70                  75                  80  


Val Tyr Thr Asn Gly Ala Ile Arg Thr Ala Tyr Thr Tyr Asn Pro Glu 
                85                  90                  95      


Pro Gln Met Tyr Ala Pro Ser Ser Thr Ala Ser Tyr Phe Glu Ala Pro 
            100                 105                 110         


Gly Gly Ala Gln Val Thr Val Ala Ala Ser Ser Pro Pro Ala Val Pro 
        115                 120                 125             


Ser His Ser Met Val Gly Ile Thr Met Asp Val Gly Gly Ser Pro Ile 
    130                 135                 140                 


Val Ser Ser Ala Gly Ala Tyr Leu Ile His Gly Gly Met Asp Ser Thr 
145                 150                 155                 160 


Arg His Ser Leu Ala His Thr Ser Arg Ser Ser Pro Ala Thr Leu Glu 
                165                 170                 175     


Met Ala Ile Glu Asn Leu Gln Lys Ser Glu Gly Ile Thr Ser His Lys 
            180                 185                 190         


Ser Gly Leu Leu Asn Ser His Leu Gln Trp Leu Leu Asp Asn Tyr Glu 
        195                 200                 205             


Thr Ala Glu Gly Val Ser Leu Pro Arg Ser Ser Leu Tyr Asn His Tyr 
    210                 215                 220                 


Leu Arg His Cys Gln Glu His Lys Leu Asp Pro Val Asn Ala Ala Ser 
225                 230                 235                 240 


Phe Gly Lys Leu Ile Arg Ser Val Phe Met Gly Leu Arg Thr Arg Arg 
                245                 250                 255     


Leu Gly Thr Arg Gly Asn Ser Lys Tyr His Tyr Tyr Gly Ile Arg Leu 
            260                 265                 270         


Lys Pro Asp Ser Pro Leu Asn Arg Leu Gln Glu Asp Thr Gln Tyr Met 
        275                 280                 285             


Ala Met Arg Gln Gln Pro Met His Gln Lys Pro Arg Tyr Arg Pro Ala 
    290                 295                 300                 


Gln Lys Thr Asp Ser Leu Gly Asp Ser Gly Ser His Ser Gly Leu His 
305                 310                 315                 320 


Ser Thr Pro Glu Gln Thr Met Ala Val Gln Ser Gln His His Gln Gln 
                325                 330                 335     


Tyr Ile Asp Val Ser His Val Phe Pro Glu Phe Pro Ala Pro Asp Leu 
            340                 345                 350         


Gly Ser Phe Leu Leu Gln Asp Gly Val Thr Leu His Asp Val Lys Ala 
        355                 360                 365             


Leu Gln Leu Val Tyr Arg Arg His Cys Glu Ala Thr Val Asp Val Val 
    370                 375                 380                 


Met Asn Leu Gln Phe His Tyr Ile Glu Lys Leu Trp Leu Ser Phe Trp 
385                 390                 395                 400 


Asn Ser Lys Ala Ser Ser Ser Asp Gly Pro Thr Ser Leu Pro Ala Ser 
                405                 410                 415     


Asp Glu Asp Pro Glu Gly Ala Val Leu Pro Lys Asp Lys Leu Ile Ser 
            420                 425                 430         


Leu Cys Gln Cys Asp Pro Ile Leu Arg Trp Met Arg Ser Cys Asp His 
        435                 440                 445             


Ile Leu Tyr Gln Ala Leu Val Glu Ile Leu Ile Pro Asp Val Leu Arg 
    450                 455                 460                 


Pro Val Pro Ser Thr Leu Thr Gln Ala Ile Arg Asn Phe Ala Lys Ser 
465                 470                 475                 480 


Leu Glu Gly Trp Leu Thr Asn Ala Met Ser Asp Phe Pro Gln Gln Val 
                485                 490                 495     


Ile Gln Thr Lys Val Gly Val Val Ser Ala Phe Ala Gln Thr Leu Arg 
            500                 505                 510         


Arg Tyr Thr Ser Leu Asn His Leu Ala Gln Ala Ala Arg Ala Val Leu 
        515                 520                 525             


Gln Asn Thr Ser Gln Ile Asn Gln Met Leu Ser Asp Leu Asn Arg Val 
    530                 535                 540                 


Asp Phe Ala Asn Val Gln Glu Gln Ala Ser Trp Val Cys Gln Cys Glu 
545                 550                 555                 560 


Glu Ser Val Val Gln Arg Leu Glu Gln Asp Phe Lys Leu Thr Leu Gln 
                565                 570                 575     


Gln Gln Ser Ser Leu Asp Gln Trp Ala Ser Trp Leu Asp Ser Val Val 
            580                 585                 590         


Thr Gln Val Leu Lys Gln His Ala Gly Ser Pro Ser Phe Pro Lys Ala 
        595                 600                 605             


Ala Arg Gln Phe Leu Leu Lys Trp Ser Phe Tyr Ser Ser Met Val Ile 
    610                 615                 620                 


Arg Asp Leu Thr Leu Arg Ser Ala Ala Ser Phe Gly Ser Phe His Leu 
625                 630                 635                 640 


Ile Arg Leu Leu Tyr Asp Glu Tyr Met Phe Tyr Leu Val Glu His Arg 
                645                 650                 655     


Val Ala Glu Ala Thr Gly Glu Thr Pro Ile Ala Val Met Gly Glu Phe 
            660                 665                 670         


Asn Asp Leu Ala Ser Leu Ser Leu Thr Leu Leu Asp Lys Asp Asp Met 
        675                 680                 685             


Gly Asp Glu Gln Arg Gly Ser Glu Ala Gly Pro Asp Ala Arg Ser Leu 
    690                 695                 700                 


Gly Glu Pro Leu Val Lys Arg Glu Arg Ser Asp Pro Asn His Ser Leu 
705                 710                 715                 720 


Gln Gly Ile 
            

<210>  534
<211>  4039
<212>  DNA
<213>  Homo sapiens

<400>  534
gcgagcgtgg gcgggccgtt aggaaggtgg ggcgcggagc ctggtaaccg ttgccggtaa     60

caacgccccg ccccgtcggg cgggcgggct gcgcgaggct ggctggcggc gggagccgga    120

ggaggagcgg ccgccgccgc caccgccgcc gccatagaga ctgtagccgt ggagactgtt    180

acttaccaac ggggaccaac acgcagcagc cgctgccgcc gccgcgggag ccgctgcccg    240

aactcccggc ccgaactcca gacctgagca tgcagaattc cgagggtgga gcggattcgc    300

cagcgtccgt ggctctgcgt ccctcggcgg cagccccgcc tgtgccagcc tccccgcaga    360

gggtgttggt ccaggcagcc agctccaatc ccaaaggggc ccagatgcag ccgatctccc    420

tccccagagt tcagcaggta ccccagcagg tgcagccggt gcagcacgtg tatcctgccc    480

aggtgcagta cgtggaaggg ggagacgccg tctacaccaa tggagccata cgaacagcct    540

acacctacaa ccccgagcct cagatgtacg cccccagcag cacggcttct tacttcgagg    600

ccccaggcgg tgcccaggtg accgtggcag cctcgtcccc gccagcggtc ccctcccaca    660

gcatggtggg catcaccatg gatgtcgggg ggagccccat cgtctccagc gcgggagcct    720

atctcatcca cggggggatg gacagcacca gacactccct ggcccacacc tcccgctcat    780

cgcccgccac gctccagtgg ctgttggata attatgaaac agcggaaggt gtgagtctcc    840

ccagaagttc tctttacaac cactaccttc ggcactgcca ggagcacaag ctagacccag    900

tgaacgccgc ctccttcggg aaactgatcc gttctgtgtt tatggggctg agaacgcggc    960

ggctgggcac caggggcaac tcgaagtacc attactatgg gattcgtctg aagccggact   1020

caccactgaa ccggctgcag gaggacacgc agtacatggc catgcggcag cagcccatgc   1080

accagaagcc caggtaccgg ccagcccaga agacggacag cctcggggac agcggctccc   1140

acagcggcct gcacagcact ccggaacaga ccatggccgt gcagagccag caccaccagc   1200

agtacataga tgtctcccac gtcttccccg agttcccagc gcccgacctg ggcagcttcc   1260

tgctgcagga cggcgtcaca ctgcacgacg tcaaggccct gcagctggtg tacagacggc   1320

actgcgaggc aactgtagat gtggtgatga acctccagtt ccactacatc gagaagctgt   1380

ggctctcctt ctggaactct aaggcctcct ccagcgacgg ccccacctct cttcctgcca   1440

gtgacgaaga ccccgagggc gccgtcctgc ccaaggacaa gcttatctcc ctgtgtcagt   1500

gcgaccccat cctcaggtgg atgaggagct gcgaccacat cctctaccag gcgctggtgg   1560

agattctcat ccccgacgtg ctgaggccgg tccccagtac cttgacacag gccatccgta   1620

actttgccaa gagcttggaa ggctggttga caaatgccat gagtgacttc ccacaacagg   1680

tcatccagac caaggtgggc gtcgtcagtg ccttcgccca gacgctgcgg cgctacacgt   1740

ccctcaacca cctggcgcag gcggcccggg cggtgctgca gaacacgtcc cagatcaacc   1800

agatgctcag cgacctcaac cgcgtggact ttgccaacgt gcaggagcag gcctcgtggg   1860

tgtgccagtg cgaggagagt gtggtgcagc ggctggagca ggatttcaag ctgaccctgc   1920

agcagcagag ctccctggac cagtgggcca gctggctgga cagtgtggtc acccaggtcc   1980

tgaagcagca tgccggcagc cccagcttcc ccaaggccgc ccggcagttc ttgctgaaat   2040

ggtcctttta cagctccatg gtgatccggg acctgaccct gcgcagcgct gccagcttcg   2100

gctccttcca cctcatccgc ctgctctacg acgagtacat gttctacctg gtggagcacc   2160

gcgtcgcgga ggccaccgga gagacgccga tcgctgtgat gggagagttc aacgatctcg   2220

cctctctgtc gctgacgctg ctcgacaaag atgacatggg cgatgagcag cgtggcagcg   2280

aggcgggccc agacgcccgc agcctgggtg agcccctggt aaagcgggag cgcagtgacc   2340

ccaaccactc cctgcagggc atctagcagc cccggccggc gcctcctcga ggttccaaaa   2400

gatgccgcct ggtcactctg ggaacctgga tttcaccggc tccaccaaat tagtgcctct   2460

tagatgatgt gatgtttact ttgactcaag cgggggctcc cggggtcagt gttcaagaag   2520

gaaagcagtt gttgaagcta cagaagccca ggccagggct cccactggct gtagctgtgc   2580

tctgggtccc caggtccctg cgcagccacc agggccccac cagaccatgg gttccttatt   2640

ctggacaaac cctcctctgc tggaaccctg gactttggcc ccagtccctt taagagctga   2700

aagggctgtg ctgagagcac tggcctctgc actcaactgg aaccaatttt caccatgatt   2760

ttaaaaatta aaaaaacctg gcagagcccg actagaaagg gacggcctct cccctcctac   2820

ctgccaccgc tggggaggca cagagctcgc cagcgtccct ggagtcccct caggaatgga   2880

aagtggagtg cccttgtctg gtagcaccat gtgggaggga cccagctggg cgcagcgccc   2940

tgtggccttt tagatccaga cctccctgcc ggatgccccg aggcgggagg ccggctgtgc   3000

tgcaggaacc catctccaga tgccaaagga cttgaggggc agctgacaat cgctgtgtcc   3060

cggcagatcc gcagctcgaa aaagaacaag ccacagaaac gggctcgctc gtgccaggac   3120

acagcagtgt ctttcaaaaa atcaaaacca gaagttttat cagcagcagg aaggatgtgg   3180

gactctgtcc aagttcaccg tcaccatcaa gccactggct gtggaaggag tttgtccaac   3240

agggtcagtg tcacagccac aacttcagaa agcagccatc ccgcgtgtcg tccaaacagc   3300

agtgcctgcg tcccgctcca cggagtcttc cagaacacct ccctctgaac taatcccgga   3360

gcaccccacc cccagcgagt cccacctgga cctcttcaaa gtcaaaactc ttctctcggg   3420

acaaacaaat attcgggact ttcgaagccc tgaacttgag acaccaagtt tgtctccatg   3480

gaaacacgta gccgctgcag ttggacagct gcgtgctgga gttctgtccc caaaccaact   3540

gcagagaaga aagacgagcc tcggcccagg acgcgatttc taacgaaatg caatagtttt   3600

ctctttttgg aaaaatgttt ataccaatag ttttgtgcgc taattgttat tagaacgttt   3660

cttatgaatg tgtacattgc agtatattca gtcccaaatg ttttgttctc attcacacag   3720

aaggtactaa tgtcagctca cgtggccttt aaaaacctac ttccccgccc gcaggagctc   3780

agagcatcgc tgggcctgcg ccagagtgag gggtgcagga agacaaagac gcgtgctcac   3840

tttagaaacg aaaagctggg aataatcaca ctgtttgtct ggtcgtatag cccaaacctt   3900

agttgaaatc agacagaaag aatgtcttta aaatatacat ctcctctcct tggagacact   3960

gaagctcaca gttaacggat tgtaatgccc ggcttttcct cactcctggt aaccaataca   4020

agctggtttc tgccttaaa                                                4039


<210>  535
<211>  698
<212>  PRT
<213>  Homo sapiens

<400>  535


Met Gln Asn Ser Glu Gly Gly Ala Asp Ser Pro Ala Ser Val Ala Leu 
1               5                   10                  15      


Arg Pro Ser Ala Ala Ala Pro Pro Val Pro Ala Ser Pro Gln Arg Val 
            20                  25                  30          


Leu Val Gln Ala Ala Ser Ser Asn Pro Lys Gly Ala Gln Met Gln Pro 
        35                  40                  45              


Ile Ser Leu Pro Arg Val Gln Gln Val Pro Gln Gln Val Gln Pro Val 
    50                  55                  60                  


Gln His Val Tyr Pro Ala Gln Val Gln Tyr Val Glu Gly Gly Asp Ala 
65                  70                  75                  80  


Val Tyr Thr Asn Gly Ala Ile Arg Thr Ala Tyr Thr Tyr Asn Pro Glu 
                85                  90                  95      


Pro Gln Met Tyr Ala Pro Ser Ser Thr Ala Ser Tyr Phe Glu Ala Pro 
            100                 105                 110         


Gly Gly Ala Gln Val Thr Val Ala Ala Ser Ser Pro Pro Ala Val Pro 
        115                 120                 125             


Ser His Ser Met Val Gly Ile Thr Met Asp Val Gly Gly Ser Pro Ile 
    130                 135                 140                 


Val Ser Ser Ala Gly Ala Tyr Leu Ile His Gly Gly Met Asp Ser Thr 
145                 150                 155                 160 


Arg His Ser Leu Ala His Thr Ser Arg Ser Ser Pro Ala Thr Leu Gln 
                165                 170                 175     


Trp Leu Leu Asp Asn Tyr Glu Thr Ala Glu Gly Val Ser Leu Pro Arg 
            180                 185                 190         


Ser Ser Leu Tyr Asn His Tyr Leu Arg His Cys Gln Glu His Lys Leu 
        195                 200                 205             


Asp Pro Val Asn Ala Ala Ser Phe Gly Lys Leu Ile Arg Ser Val Phe 
    210                 215                 220                 


Met Gly Leu Arg Thr Arg Arg Leu Gly Thr Arg Gly Asn Ser Lys Tyr 
225                 230                 235                 240 


His Tyr Tyr Gly Ile Arg Leu Lys Pro Asp Ser Pro Leu Asn Arg Leu 
                245                 250                 255     


Gln Glu Asp Thr Gln Tyr Met Ala Met Arg Gln Gln Pro Met His Gln 
            260                 265                 270         


Lys Pro Arg Tyr Arg Pro Ala Gln Lys Thr Asp Ser Leu Gly Asp Ser 
        275                 280                 285             


Gly Ser His Ser Gly Leu His Ser Thr Pro Glu Gln Thr Met Ala Val 
    290                 295                 300                 


Gln Ser Gln His His Gln Gln Tyr Ile Asp Val Ser His Val Phe Pro 
305                 310                 315                 320 


Glu Phe Pro Ala Pro Asp Leu Gly Ser Phe Leu Leu Gln Asp Gly Val 
                325                 330                 335     


Thr Leu His Asp Val Lys Ala Leu Gln Leu Val Tyr Arg Arg His Cys 
            340                 345                 350         


Glu Ala Thr Val Asp Val Val Met Asn Leu Gln Phe His Tyr Ile Glu 
        355                 360                 365             


Lys Leu Trp Leu Ser Phe Trp Asn Ser Lys Ala Ser Ser Ser Asp Gly 
    370                 375                 380                 


Pro Thr Ser Leu Pro Ala Ser Asp Glu Asp Pro Glu Gly Ala Val Leu 
385                 390                 395                 400 


Pro Lys Asp Lys Leu Ile Ser Leu Cys Gln Cys Asp Pro Ile Leu Arg 
                405                 410                 415     


Trp Met Arg Ser Cys Asp His Ile Leu Tyr Gln Ala Leu Val Glu Ile 
            420                 425                 430         


Leu Ile Pro Asp Val Leu Arg Pro Val Pro Ser Thr Leu Thr Gln Ala 
        435                 440                 445             


Ile Arg Asn Phe Ala Lys Ser Leu Glu Gly Trp Leu Thr Asn Ala Met 
    450                 455                 460                 


Ser Asp Phe Pro Gln Gln Val Ile Gln Thr Lys Val Gly Val Val Ser 
465                 470                 475                 480 


Ala Phe Ala Gln Thr Leu Arg Arg Tyr Thr Ser Leu Asn His Leu Ala 
                485                 490                 495     


Gln Ala Ala Arg Ala Val Leu Gln Asn Thr Ser Gln Ile Asn Gln Met 
            500                 505                 510         


Leu Ser Asp Leu Asn Arg Val Asp Phe Ala Asn Val Gln Glu Gln Ala 
        515                 520                 525             


Ser Trp Val Cys Gln Cys Glu Glu Ser Val Val Gln Arg Leu Glu Gln 
    530                 535                 540                 


Asp Phe Lys Leu Thr Leu Gln Gln Gln Ser Ser Leu Asp Gln Trp Ala 
545                 550                 555                 560 


Ser Trp Leu Asp Ser Val Val Thr Gln Val Leu Lys Gln His Ala Gly 
                565                 570                 575     


Ser Pro Ser Phe Pro Lys Ala Ala Arg Gln Phe Leu Leu Lys Trp Ser 
            580                 585                 590         


Phe Tyr Ser Ser Met Val Ile Arg Asp Leu Thr Leu Arg Ser Ala Ala 
        595                 600                 605             


Ser Phe Gly Ser Phe His Leu Ile Arg Leu Leu Tyr Asp Glu Tyr Met 
    610                 615                 620                 


Phe Tyr Leu Val Glu His Arg Val Ala Glu Ala Thr Gly Glu Thr Pro 
625                 630                 635                 640 


Ile Ala Val Met Gly Glu Phe Asn Asp Leu Ala Ser Leu Ser Leu Thr 
                645                 650                 655     


Leu Leu Asp Lys Asp Asp Met Gly Asp Glu Gln Arg Gly Ser Glu Ala 
            660                 665                 670         


Gly Pro Asp Ala Arg Ser Leu Gly Glu Pro Leu Val Lys Arg Glu Arg 
        675                 680                 685             


Ser Asp Pro Asn His Ser Leu Gln Gly Ile 
    690                 695             

<210>  536
<211>  3605
<212>  DNA
<213>  Homo sapiens

<400>  536
gcgggattct gggaaatgtc gatcggctgt gggcggcgca ctgggtccgc cccgctgtag     60

cctcaggcct gacggcgact cccaggctcc gggacgattc tgggcagtgt cgtccccaga    120

ggtcggcggc cgttgcccgc tcaccagcga cgcggggcgc ctgcggggac ggtgaggccc    180

tgctgaggac tccggccagt atgagtcccg ggggcggcgg cggggctcag gccctgggtc    240

tgccccgcgg tgtgaccccg gccggtgcct tggttttcct ggccttcatg tcctcctatg    300

taaacgcggg gtgatgacgg cgccgacctc ttggcgctgt tgtgagagtg aagtgggcgc    360

gtggttagac gccagccaca gttgtctttg ggttatgtcg tcatgaagcc ggcgctctac    420

agttgtgtaa ccttgaacaa atgggttcag tatcttggaa tttcagtttt gtcatcgttt    480

taaaaaatag atctggaaaa atgtgaacgc acaccgtgca tagtggtgaa gactgaacga    540

gctgataaag tttttaccat tgttttatga ggattttatt tacagagtaa ttgattttcc    600

tcgcaggtgg cacctggtaa atggttagcc cttgcggaga aacaccctgt tagttcccag    660

ggagagattg gcgccctgga gagtgattac cagtgtgcct ttccattatg gtgtgtcaca    720

ggtgccgcaa gataagcctg atttttcatg actgcttttt cctgcccttc tgtgccctca    780

ggacactgcc catctctaag ataagagcct ggaaagagga ctctgttggc tgttggaaat    840

tgcagagtaa tgcctcaggt gacatttaat gatgtggcta tagacttcac tcatgaagag    900

tggggatggc tcagttctgc tcagagggac ttatacaagg atgtgatggt ccagaattat    960

gagaacctgg tctctgtagg taaggatatt accccttcca ctccagtagg ggacaccttt   1020

cttttgccac cctgaattgc tggagaccct cctaagtaaa tggctgaatt tctgtagcat   1080

gttcccaagg aaatgtgcag ctctgttgtg ccctgcctga agcttatctt tccatttcga   1140

tgaataccct tcatcccttc ctgtggtccc tcttgtgatg gcctctcata atagaggacc   1200

acggcttaaa caattctgta ttcttcctgt aagcaggtct ttctgtaact aagccatatg   1260

tgatcacgtt attggaggat ggaaaagagc cctggatgat ggagaaaaaa ctgtcaaaag   1320

gtatgattcc agattgggaa tcaagatggg aaaacaagga attatcaaca aagaaggata   1380

attatgatga agattcaccc caaacagtaa taatagaaaa agttgtaaaa caaagttatg   1440

aattttcaaa ttctaagaag aatttggaat atatagagaa gttggaaggg aagcatggaa   1500

gtcaggtaga ccatttcaga ccagcaattc tcacctctag agaaagcccc actgcagaca   1560

gtgtttacaa atacaatata tttagaagca cctttcattc aaagtctact ctttctgaac   1620

cacaaaaaat ttctgctgaa gggaattcac acaaatatga tatattaaag aagaacttac   1680

caaaaaagtc agttataaaa aatgagaaag tcaatggtgg aaagaaactt ttgaattcta   1740

ataaaagtgg ggcagccttc agccagggca aatctcttac ccttccccag acttgtaata   1800

gagagaaaat ctatacatgc agtgaatgtg ggaaagcctt tggcaaacag tcaatcctca   1860

atcgccactg gagaattcat acaggagaga agccctatga atgtcgtgaa tgtgggaaga   1920

cttttagcca tggctcatcc cttacacgac atctgataag ccatagtgga gagaaacctt   1980

acaaatgtat tgaatgtggg aaggccttta gccatgtctc atcacttact aaccatcaga   2040

gcactcacac tggagagaaa ccatatgaat gtatgaactg tggaaagtct tttagtcgtg   2100

tgtcccatct tattgaacat ctaagaattc atactcaaga aaaactctat gagtgtcgta   2160

tatgtggaaa ggccttcatt cataggtcat ctctcattca ccatcagaaa atccatactg   2220

gagagaagcc ttatgaatgt agagaatgtg ggaaagcttt ctgctgtagc tcacacctta   2280

ctcgacatca aagaattcac actatggaga aacaatatga atgcaacaaa tgtctgaaag   2340

tctttagtag cctctcattt cttgttcagc atcagagtat tcatactgaa gaaaaaccct   2400

ttgaatgtca gaaatgcagg aaatccttca accagcttga atcactgaat atgcatttga   2460

gaaatcacat tagattgaaa ccctacgaat gcagtatatg tgggaaagcc tttagtcata   2520

ggtcatccct gcttcaacat cacagaattc atactggaga gaaaccttat gaatgtatta   2580

aatgtgggaa gaccttcagc tgtagttcaa accttaccgt acatcagaga attcacactg   2640

gagaaaagcc atataaatgt aatgagtgtg ggaaagcttt tagcaaaggc tcaaatctta   2700

ctgcccatca aagagtacat aatggagaga aacccaatag tgtggtaagt gtggaaaagc   2760

ctttagacta tatgaatcac tatacatgtg agaaatctta cagaagagaa actgtatgaa   2820

gcagtggtta tcatggtaaa tttcctagat tctcccttat ttaacattag aaaaatttat   2880

actggggaaa gtcttatgaa tgtggtgaat ataggaagac cttttagcaa agatgcaggc   2940

cagtttgttt attagacttt atactgtaga gaaatcatat gaagaccata aatgtgggaa   3000

agcctttgtc agtattaatc ccttaattga cataagtata ctcacactag gataaaaccc   3060

tgtacatgta gcaaatgtgg gaaagactac agacaatagg aatcttttac aaactcctac   3120

aggagagaag ctgtatgaat gtagaaaatt tagaaattga gggaagtctt cagttccaag   3180

tatatccctt attctacagc agagaactca aaatggagag aaatctcatt taagagatgt   3240

agcaaagtgt tcactaagag tgtttatctt ggtacacatc agaagattaa tggtagaaca   3300

acctgaagga tttaggagtt atgtgtaaat ctttgcagtc atgctatttg taaactggat   3360

tctacaggag agcaaataaa cattataata aaatatgcat ttcttagagc agtagcttgc   3420

agtttcagtt gagttctact tagaaattct ttttagctag tgggcatgtg aagatattta   3480

gtcacccaga ggagccagta agtgttataa tattgaaaat taaagctgca aaagaaataa   3540

agtgatgtta ataaaagttt tggcatctaa taaaatcatt ttgtatatca aaaaaaaaaa   3600

aaaaa                                                               3605


<210>  537
<211>  507
<212>  PRT
<213>  Homo sapiens

<400>  537


Met Met Glu Lys Lys Leu Ser Lys Gly Met Ile Pro Asp Trp Glu Ser 
1               5                   10                  15      


Arg Trp Glu Asn Lys Glu Leu Ser Thr Lys Lys Asp Asn Tyr Asp Glu 
            20                  25                  30          


Asp Ser Pro Gln Thr Val Ile Ile Glu Lys Val Val Lys Gln Ser Tyr 
        35                  40                  45              


Glu Phe Ser Asn Ser Lys Lys Asn Leu Glu Tyr Ile Glu Lys Leu Glu 
    50                  55                  60                  


Gly Lys His Gly Ser Gln Val Asp His Phe Arg Pro Ala Ile Leu Thr 
65                  70                  75                  80  


Ser Arg Glu Ser Pro Thr Ala Asp Ser Val Tyr Lys Tyr Asn Ile Phe 
                85                  90                  95      


Arg Ser Thr Phe His Ser Lys Ser Thr Leu Ser Glu Pro Gln Lys Ile 
            100                 105                 110         


Ser Ala Glu Gly Asn Ser His Lys Tyr Asp Ile Leu Lys Lys Asn Leu 
        115                 120                 125             


Pro Lys Lys Ser Val Ile Lys Asn Glu Lys Val Asn Gly Gly Lys Lys 
    130                 135                 140                 


Leu Leu Asn Ser Asn Lys Ser Gly Ala Ala Phe Ser Gln Gly Lys Ser 
145                 150                 155                 160 


Leu Thr Leu Pro Gln Thr Cys Asn Arg Glu Lys Ile Tyr Thr Cys Ser 
                165                 170                 175     


Glu Cys Gly Lys Ala Phe Gly Lys Gln Ser Ile Leu Asn Arg His Trp 
            180                 185                 190         


Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Arg Glu Cys Gly Lys 
        195                 200                 205             


Thr Phe Ser His Gly Ser Ser Leu Thr Arg His Leu Ile Ser His Ser 
    210                 215                 220                 


Gly Glu Lys Pro Tyr Lys Cys Ile Glu Cys Gly Lys Ala Phe Ser His 
225                 230                 235                 240 


Val Ser Ser Leu Thr Asn His Gln Ser Thr His Thr Gly Glu Lys Pro 
                245                 250                 255     


Tyr Glu Cys Met Asn Cys Gly Lys Ser Phe Ser Arg Val Ser His Leu 
            260                 265                 270         


Ile Glu His Leu Arg Ile His Thr Gln Glu Lys Leu Tyr Glu Cys Arg 
        275                 280                 285             


Ile Cys Gly Lys Ala Phe Ile His Arg Ser Ser Leu Ile His His Gln 
    290                 295                 300                 


Lys Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Arg Glu Cys Gly Lys 
305                 310                 315                 320 


Ala Phe Cys Cys Ser Ser His Leu Thr Arg His Gln Arg Ile His Thr 
                325                 330                 335     


Met Glu Lys Gln Tyr Glu Cys Asn Lys Cys Leu Lys Val Phe Ser Ser 
            340                 345                 350         


Leu Ser Phe Leu Val Gln His Gln Ser Ile His Thr Glu Glu Lys Pro 
        355                 360                 365             


Phe Glu Cys Gln Lys Cys Arg Lys Ser Phe Asn Gln Leu Glu Ser Leu 
    370                 375                 380                 


Asn Met His Leu Arg Asn His Ile Arg Leu Lys Pro Tyr Glu Cys Ser 
385                 390                 395                 400 


Ile Cys Gly Lys Ala Phe Ser His Arg Ser Ser Leu Leu Gln His His 
                405                 410                 415     


Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Ile Lys Cys Gly Lys 
            420                 425                 430         


Thr Phe Ser Cys Ser Ser Asn Leu Thr Val His Gln Arg Ile His Thr 
        435                 440                 445             


Gly Glu Lys Pro Tyr Lys Cys Asn Glu Cys Gly Lys Ala Phe Ser Lys 
    450                 455                 460                 


Gly Ser Asn Leu Thr Ala His Gln Arg Val His Asn Gly Glu Lys Pro 
465                 470                 475                 480 


Asn Ser Val Val Ser Val Glu Lys Pro Leu Asp Tyr Met Asn His Tyr 
                485                 490                 495     


Thr Cys Glu Lys Ser Tyr Arg Arg Glu Thr Val 
            500                 505         

<210>  538
<211>  3115
<212>  DNA
<213>  Homo sapiens

<400>  538
gtgggcggga cttccggcgt ccagtcttcg tccgccgtta ggttgcggct gctgtggttg     60

ccaacgctac actgggtaga acgccagaca ggggccactt ttcgagaccg agtagagacg    120

gacagtgagg aggataggac ccacttacac gcttttatgt cagccgcgat cccaccccca    180

caagcgtctg caaaaccctt cctggggcct tggcgacagc cctgtgtcct cacggcgcgc    240

agaggcggcg ccgcgaacct tgtgtgcatt ttacacgacg gcggggactg aggtccctcg    300

cagcccagag ccggagcccg gggtcggccg agcccgcagg accggcttcc tcgccgactc    360

tcacggcctc acccagcccc ctgggcccat ggcggcgccg gcgttggcat tagtatcatt    420

tgaagacgtg gttgtgacct tcactggaga ggaatggggg cacctggacc tggcccagag    480

gaccctgtac caggaggtga tgctggagac ctgcaggctc ctggtctcac tggggcatcc    540

tgttcccaaa ccagagctga tctatctact ggaacatgga caggaactgt ggacagtgaa    600

gagaggcctc tcccaaagca cctgcgcagg tgaaaaagca aaacccaaga ttacagagcc    660

tactgcttct cagctggcct tctctgagga atcctctttc caggaacttc tggcacagag    720

atcctcaaga gattccaggt tggggcaagc tagagatgag gaaaagctaa taaaaattca    780

ggaagggaac ttgaggccag gaacaaaccc ccacaaagag atatgccctg agaagttgag    840

ttataaacat gatgatttgg agccagatga tagtctgggc ttaagggttt tacaggaacg    900

agtcactcca caagatgctc tccatgagtg tgactctcaa ggaccaggaa aagaccccat    960

gactgatgca aggaataacc cttacacatg cacggaatgt gggaaagggt ttagcaagaa   1020

gtgggccctt gttcggcatc aacagattca tgctggagtg aagccctatg agtgcaatga   1080

gtgtgggaaa gcctgtcgtt atatggctga tgtcattcga catatgaggc ttcatactgg   1140

ggaaaaacca tacaagtgta ttgagtgtgg gaaagccttc aaacgcaggt ttcacctcac   1200

ggagcaccag cgtattcaca ccggagataa gccctatgag tgcaaagaat gtggcaaagc   1260

attcacccac cgctcttctt ttatccagca taatatgact cacactcgag aaaaaccctt   1320

tttatgcaaa gaatgtggga aagcttttta ctacagctcc tcatttgctc aacatatgag   1380

gattcatact ggaaagaaac tctatgagtg cggtgaatgt ggaaaggcct tcacgcaccg   1440

ctccacattt atccagcaca atgtgaccca cacaggagaa aaaccatttt tatgtaaaga   1500

atgtggaaaa accttttgcc tcaactcatc cttcactcag cacatgagga ttcacactgg   1560

agagaaaccc tatgagtgcg gtgaatgtgg aaaggccttt actcatcgct ccactttcat   1620

ccgacataag aggacccata ccggagagaa gccctttgag tgcaaagaat gtgggaaggc   1680

cttttgtgac agctcttcct taattcaaca tatgaggatt cacactggtg agaagcctta   1740

tgagtgcagt gaatgtggaa aggcttttac acaccactct gtttttattc gacataatag   1800

gacccacagt ggacaaaaac ccttggagtg caaagaatgt gcaaaagcct tttactatag   1860

ctcttccttc actcgacaca tgaggattca cactggagag aagccctatg tttgtagaga   1920

atgtggaaag gcttttaccc aacctgcaaa ttttgttcgg cataatagga tccacactgg   1980

agaaaaacct tttgaatgca aagaatgtga gaaagccttc tgtgacaact ttgctttaac   2040

tcagcacatg agaactcaca ctggagagaa accctttgaa tgcaatgaat gtggaaagac   2100

cttcagccac agttcatcgt tcactcacca tcgaaagatt cataccagag tttaaaagat   2160

acaggaaggc ctattacaag tgtgtttgtc tttagtgaac tcatagtggt gacatacctt   2220

tccttttgag tataactatt gagggaaata ttttggccag agagatgtct tagtatctga   2280

taatttatac taactagaaa cagaattgtc cctgtgaaat ctttttatgg caggtaatca   2340

cttgtcatcc aaagaattat attaaagatt cacccagttt agagccttac actgtacctg   2400

agaataatcg aggggagaga cctggtggtt aacatgcatt taggtaaaat gtcaggaaca   2460

actttcctct tattaatact ataaatccat ctcaagcata ttttaaaata atgagagatg   2520

gaggaaacaa tctagaagat aaaagaaaaa gatgtgcata acttgttttc agtttccctg   2580

tttatgacag tttgtcattt ggcgggttgg gggatggagc agggaataag acattgaaaa   2640

agtctcatcc cctttgtgtg ttttacatat atatatctct aagtccagag ccaggagagt   2700

tggaccattg agggcagctc tgccaacatt tagtaaaagt attcattgtt ccaaaactgt   2760

catctctacc cttgagggag tgtgtctttg tgagaaatat aaaggcttga gtcatgaaat   2820

acttaacaca tgtgcacatg tacacatgta catttatatg cagtgaattg ttactcgtgg   2880

tagttaggtt ctgtgaattt tctgtgcaca ctgaattagt gaatgctgaa tgattgttgc   2940

taggggaaat acagcgttag cttctgtgag cctctgatcc aaacattttt atcaaccagt   3000

caacacataa ccttcttcta tgggtatttg tttgtttgtt tgtttaaaga cactttatca   3060

gtgtttcttg aataattata attattcttt ataataaaaa tattttaatt atagc        3115


<210>  539
<211>  588
<212>  PRT
<213>  Homo sapiens

<400>  539


Met Ala Ala Pro Ala Leu Ala Leu Val Ser Phe Glu Asp Val Val Val 
1               5                   10                  15      


Thr Phe Thr Gly Glu Glu Trp Gly His Leu Asp Leu Ala Gln Arg Thr 
            20                  25                  30          


Leu Tyr Gln Glu Val Met Leu Glu Thr Cys Arg Leu Leu Val Ser Leu 
        35                  40                  45              


Gly His Pro Val Pro Lys Pro Glu Leu Ile Tyr Leu Leu Glu His Gly 
    50                  55                  60                  


Gln Glu Leu Trp Thr Val Lys Arg Gly Leu Ser Gln Ser Thr Cys Ala 
65                  70                  75                  80  


Gly Glu Lys Ala Lys Pro Lys Ile Thr Glu Pro Thr Ala Ser Gln Leu 
                85                  90                  95      


Ala Phe Ser Glu Glu Ser Ser Phe Gln Glu Leu Leu Ala Gln Arg Ser 
            100                 105                 110         


Ser Arg Asp Ser Arg Leu Gly Gln Ala Arg Asp Glu Glu Lys Leu Ile 
        115                 120                 125             


Lys Ile Gln Glu Gly Asn Leu Arg Pro Gly Thr Asn Pro His Lys Glu 
    130                 135                 140                 


Ile Cys Pro Glu Lys Leu Ser Tyr Lys His Asp Asp Leu Glu Pro Asp 
145                 150                 155                 160 


Asp Ser Leu Gly Leu Arg Val Leu Gln Glu Arg Val Thr Pro Gln Asp 
                165                 170                 175     


Ala Leu His Glu Cys Asp Ser Gln Gly Pro Gly Lys Asp Pro Met Thr 
            180                 185                 190         


Asp Ala Arg Asn Asn Pro Tyr Thr Cys Thr Glu Cys Gly Lys Gly Phe 
        195                 200                 205             


Ser Lys Lys Trp Ala Leu Val Arg His Gln Gln Ile His Ala Gly Val 
    210                 215                 220                 


Lys Pro Tyr Glu Cys Asn Glu Cys Gly Lys Ala Cys Arg Tyr Met Ala 
225                 230                 235                 240 


Asp Val Ile Arg His Met Arg Leu His Thr Gly Glu Lys Pro Tyr Lys 
                245                 250                 255     


Cys Ile Glu Cys Gly Lys Ala Phe Lys Arg Arg Phe His Leu Thr Glu 
            260                 265                 270         


His Gln Arg Ile His Thr Gly Asp Lys Pro Tyr Glu Cys Lys Glu Cys 
        275                 280                 285             


Gly Lys Ala Phe Thr His Arg Ser Ser Phe Ile Gln His Asn Met Thr 
    290                 295                 300                 


His Thr Arg Glu Lys Pro Phe Leu Cys Lys Glu Cys Gly Lys Ala Phe 
305                 310                 315                 320 


Tyr Tyr Ser Ser Ser Phe Ala Gln His Met Arg Ile His Thr Gly Lys 
                325                 330                 335     


Lys Leu Tyr Glu Cys Gly Glu Cys Gly Lys Ala Phe Thr His Arg Ser 
            340                 345                 350         


Thr Phe Ile Gln His Asn Val Thr His Thr Gly Glu Lys Pro Phe Leu 
        355                 360                 365             


Cys Lys Glu Cys Gly Lys Thr Phe Cys Leu Asn Ser Ser Phe Thr Gln 
    370                 375                 380                 


His Met Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Gly Glu Cys 
385                 390                 395                 400 


Gly Lys Ala Phe Thr His Arg Ser Thr Phe Ile Arg His Lys Arg Thr 
                405                 410                 415     


His Thr Gly Glu Lys Pro Phe Glu Cys Lys Glu Cys Gly Lys Ala Phe 
            420                 425                 430         


Cys Asp Ser Ser Ser Leu Ile Gln His Met Arg Ile His Thr Gly Glu 
        435                 440                 445             


Lys Pro Tyr Glu Cys Ser Glu Cys Gly Lys Ala Phe Thr His His Ser 
    450                 455                 460                 


Val Phe Ile Arg His Asn Arg Thr His Ser Gly Gln Lys Pro Leu Glu 
465                 470                 475                 480 


Cys Lys Glu Cys Ala Lys Ala Phe Tyr Tyr Ser Ser Ser Phe Thr Arg 
                485                 490                 495     


His Met Arg Ile His Thr Gly Glu Lys Pro Tyr Val Cys Arg Glu Cys 
            500                 505                 510         


Gly Lys Ala Phe Thr Gln Pro Ala Asn Phe Val Arg His Asn Arg Ile 
        515                 520                 525             


His Thr Gly Glu Lys Pro Phe Glu Cys Lys Glu Cys Glu Lys Ala Phe 
    530                 535                 540                 


Cys Asp Asn Phe Ala Leu Thr Gln His Met Arg Thr His Thr Gly Glu 
545                 550                 555                 560 


Lys Pro Phe Glu Cys Asn Glu Cys Gly Lys Thr Phe Ser His Ser Ser 
                565                 570                 575     


Ser Phe Thr His His Arg Lys Ile His Thr Arg Val 
            580                 585             

<210>  540
<211>  12644
<212>  DNA
<213>  Homo sapiens

<400>  540
cctcccgcct cagttcgcgc cgcgcctcgg cttggaacgc aggagcgccg gctccgggag     60

cccgagcgga gccagccgcg cgcacagcca gcggccgcgc cggcgatgcg gggccacccc    120

gcgcccgccc cagtcccggc cccggccccc gcgggaaggg gctgagctgc ccgccgccgc    180

ccggatggcg agcctcgccg cgctcgccct cagcctgctc ctgaggctgc agctgccgcc    240

actgcccggc gcccgggctc agagcgccgc aggtggctgt tcctttgatg agcactacag    300

caactgtggt tatagtgtgg ctctagggac caatgggttc acctgggagc agattaacac    360

atgggagaaa ccaatgctgg accaggcagt gcccacagga tctttcatga tggtgaacag    420

ctctgggaga gcctctggcc agaaggccca ccttctcctg ccaaccctga aggagaatga    480

cacccactgc atcgacttcc attactactt ctccagccgt gacaggtcca gcccaggggc    540

cttgaacgtc tacgtgaagg tgaatggtgg cccccaaggg aaccctgtgt ggaatgtgtc    600

cggggtcgtc actgagggct gggtgaaggc agagctcgcc atcagcactt tctggccaca    660

tttctatcag gtgatatttg aatccgtctc attgaagggt catcctggct acatcgccgt    720

ggacgaggtc cgggtccttg ctcatccatg cagaaaagca cctcattttc tgcgactcca    780

aaacgtggag gtgaatgtgg ggcagaatgc cacatttcag tgcattgctg gtgggaagtg    840

gtctcagcat gacaagcttt ggctccagca atggaatggc agggacacgg ccctgatggt    900

cacccgtgtg gtcaaccaca ggcgcttctc agccacagtc agtgtggcag acactgccca    960

gcggagcgtc agcaagtacc gctgtgtgat ccgctctgat ggtgggtctg gtgtgtccaa   1020

ctacgcggag ctgatcgtga aagagcctcc cacgcccatt gctcccccag agctgctggc   1080

tgtgggggcc acatacctgt ggatcaagcc aaatgccaac tccatcatcg gggatggccc   1140

catcatcctg aaggaagtgg aatatcgcac caccacaggc acgtgggcag agacccacat   1200

agtcgactct cccaactata agctgtggca tctggacccc gatgttgagt atgagatccg   1260

agtgctcctc acacgaccag gtgagggggg tacgggaccg ccagggcctc ccctcaccac   1320

caggaccaag tgtgcagatc cggtacatgg cccacagaac gtggaaatcg tagacatcag   1380

agcccggcag ctgaccctgc agtgggagcc cttcggctac gcggtgaccc gctgccatag   1440

ctacaacctc accgtgcagt accagtatgt gttcaaccag cagcagtacg aggccgagga   1500

ggtcatccag acctcctccc actacaccct gcgaggcctg cgccccttca tgaccatccg   1560

gctgcgactc ttgctgtcta accccgaggg ccgaatggag agcgaggagc tggtggtgca   1620

gactgaggaa gacgttccag gagctgttcc tctagaatcc atccaagggg ggccctttga   1680

ggagaagatc tacatccagt ggaaacctcc caatgagacc aatggggtca tcacgctcta   1740

cgagatcaac tacaaggctg tcggctcgct ggacccaagt gctgacctct cgagccagag   1800

ggggaaagtg ttcaagctcc ggaatgaaac ccaccacctc tttgtgggtc tgtacccagg   1860

gaccacctat tccttcacca tcaaggccag cacagcaaag ggctttgggc cccctgtcac   1920

cactcggatt gccaccaaaa tttcagctcc atccatgcct gagtacgaca cagacacccc   1980

attgaatgag acagacacga ccatcacagt gatgctgaaa cccgctcagt cccggggagc   2040

tcctgtcagt gtttatcagc tggttgtcaa ggaggagcga cttcagaagt cacggagggc   2100

agctgacatt attgagtgct tttcggtgcc cgtgagctat cggaatgcct ccagcctcga   2160

ttctctacac tactttgctg ctgagttgaa gcctgccaac ctgcctgtca cccagccatt   2220

tacagtgggt gacaataaga catacaatgg ctactggaac cctcctctct ctcccctgaa   2280

aagctacagc atctacttcc aggcactcag caaagccaat ggagagacca aaatcaactg   2340

tgttcgtctg gctacaaaag gtgcctccac ccagaattct aacactgtgg agccagagaa   2400

gcaggtggac aacaccgtga agatggctgg cgtgatcgct ggcctcctca tgttcatcat   2460

cattctcctg ggcgtgatgc tcaccatcaa aaggagaaga aatgcttatt cctactccta   2520

ttacttgaag ctggccaaga agcagaagga gacccagagt ggagcccaga gggagatggg   2580

gcctgtggcc tctgccgaca aacccaccac caagctcagc gccagccgca atgatgaagg   2640

cttctcttct agttctcagg acgtcaacgg attcacagat ggcagccgcg gggagctttc   2700

ccagcccacc ctcacgatcc agactcatcc ctaccgcacc tgtgaccctg tggagatgag   2760

ctacccccgg gaccagttcc aacccgccat ccgggtggct gacttgctgc agcacatcac   2820

gcagatgaag agaggccagg gctacgggtt caaggaggaa tacgaggcct taccagaggg   2880

gcagacagct tcgtgggaca cagccaagga ggatgaaaac cgcaataaga atcgatatgg   2940

gaacatcata tcctacgacc attcccgggt gaggctgctg gtgctggatg gagacccgca   3000

ctctgactac atcaatgcca actacattga cggataccat cgacctcggc actacattgc   3060

gactcaaggt ccgatgcagg agactgtaaa ggacttttgg agaatgatct ggcaggagaa   3120

ctccgccagc atcgtcatgg tcacaaacct ggtggaagtg ggcagggtga aatgtgtgcg   3180

atactggcca gatgacacgg aggtctacgg agacattaaa gtcaccctga ttgaaacaga   3240

gcccctggca gaatacgtca tacgcacctt cacagtccag aagaaaggct accatgagat   3300

ccgggagctc cgcctcttcc acttcaccag ctggcctgac cacggcgttc cctgctatgc   3360

cactggcctt ctgggcttcg tccgccaggt caagttcctc aaccccccgg aagctgggcc   3420

catagtggtc cactgcagtg ctggggctgg gcggactggc tgcttcattg ccattgacac   3480

catgcttgac atggccgaga atgaaggggt ggtggacatc ttcaactgcg tgcgtgagct   3540

ccgggcccaa agggtcaacc tggtacagac agaggagcaa tatgtgtttg tgcacgatgc   3600

catcctggaa gcgtgcctct gtggcaacac tgccatccct gtgtgtgagt tccgttctct   3660

ctactacaat atcagcaggc tggaccccca gacaaactcc agccaaatca aagatgaatt   3720

tcagaccctc aacattgtga caccccgtgt gcggcccgag gactgcagca ttgggctcct   3780

gccccggaac catgataaga atcgaagtat ggacgtgctg cctctggacc gctgcctgcc   3840

cttccttatc tcagtggacg gagaatccag caattacatc aacgcagcac tgatggatag   3900

ccacaagcag cctgccgcct tcgtggtcac ccagcaccct ctacccaaca ccgtggcaga   3960

cttctggagg ctggtgttcg attacaactg ctcctctgtg gtgatgctga atgagatgga   4020

cactgcccag ttctgtatgc agtactggcc tgagaagacc tccgggtgct atgggcccat   4080

ccaggtggag ttcgtctccg cagacatcga cgaggacatc atccacagaa tattccgcat   4140

ctgtaacatg gcccggccac aggatggtta tcgtatagtc cagcacctcc agtacattgg   4200

ctggcctgcc taccgggaca cgcccccctc caagcgctct ctgctcaaag tggtccgacg   4260

actggagaag tggcaggagc agtatgacgg gagggaggga cgtactgtgg tccactgcct   4320

aaatggggga ggccgtagtg gaaccttctg tgccatctgc agtgtgtgtg agatgatcca   4380

gcagcaaaac atcattgacg tgttccacat cgtgaaaaca ctgcgtaaca acaaatccaa   4440

catggtggag accctggaac agtataaatt tgtatacgag gtggcactgg aatatttaag   4500

ctccttttag ctcaatggga tggggaacct gccggagtcc agaggctgct gtgaccaagc   4560

ccccttttgt gtgaatggca gtaactgggc tcaggagctc tgaggtggca ccctgcctga   4620

ctccaaggag aagactggtg gccctgtgtt ccacgggggg ctctgcacct tctgaggggt   4680

ctcctgttgc cgtgggagat gctgctccaa aaggcccagg cttccttttc aacctaacca   4740

gccacagcca agggcccaag cagaagtaca cccacaagca aggccttgga tttctggctc   4800

ccagaccacc tgcttttgtt ctgagtttgt ggatctcttg gcaagccaac tgtgcaggtg   4860

ctggggagtg ggaggctccc ctgccctcct tctccttagg agtggaggag atgtgtgttc   4920

tgctcctcta cgtcatggaa aagattgagg ctcttggggg tcactgctct gctgccccct   4980

gcaacctcct tcaggggcct ctggcaccag acatttgcag tctggaccag tgtgacctta   5040

cgatgttccc taggccacaa gagaggcccc ccatcctcac acctaacctg catggggctt   5100

cgcccacaac cattctgtac cccttcccca gcctgggcct tgaccgtcca gcattcactg   5160

gccggccagc tgtgtccaca gcagtttttg ataaaggtgt tctttgcttt tttgtgtggt   5220

cagtgggagg gggtggaact gcagggaact tctctgctcc tccttgtctt tgtaaaaagg   5280

gaccacctcc ctggggcagg gcttgggctg acctgtagga tgtaacccct gtgtttcttt   5340

ggtggtagct ttctttggaa gagacaaaca agataagatt tgattatttt ccaaagtgta   5400

tgtgaaaaga aactttcttt tggagggtgt aaaatcttag tctcttatgt caaaaagaag   5460

ggggcggggg agtttgagta tgtacctcta agacaaatct ctcgggcctt ttattttttc   5520

ctggcaatgt ccttaaaagc tcccaccctg ggacagcatg ccactgagca aggagagatg   5580

ggtgagcctg aagatggtcc ctttggtttc tggggcaaat agagcaccag ctttgtgcat   5640

aatttggatg tccaaatttg aactccttcc taaagaaacc cagcagccac cttgaaaaag   5700

gccattgtgg agcccattat actttgattt aaaataggcc aagagaatca ggcctggaga   5760

tctagggtct tgtccaaagt gtgagtgagt caatgagagg gaaccaacat ttgctaagtc   5820

tctactgtat gccagggatc atgcttggca ctttccatag gacatttcac acagtcctta   5880

gaacccccag gagagagcta ctgacttgtt atcatctcca tttgatcatc tcctccaatg   5940

aggaaaccca cgcaccttcc ttagtaatga aatcctgggt tccaaagggg caggtaatgg   6000

caatgagact tctccgtgct gttttcttca tcttctctaa gccaagcaat tattttatgg   6060

agggaaaata aggccagaaa cttctgagca gataactcca caaatggaaa tttagtactt   6120

tcttcctgat gccagttctt ctgggaagcg cagaatttca gatatatttt agtaacacat   6180

tcccagctcc ccaggaaagc cagtctcatc taatttctta gtcagtaaaa acaattccct   6240

gttccttcag gctatgaatg gaccagccag ggaaactctc gaccttgatc tctagccagt   6300

gcttaggccc aatatctgac agcctcaggt gggctgggac ctaggaagct ccatcttgaa   6360

ggctggtcta gccccagaca gggcatgagg ggcagagaat tcaagaaggt acagctttgg   6420

ccctcaagag cccactgtat gctggggaaa tggaaccatg gtgcagtagt gtggagtgga   6480

tgagtgttcc atgagcctag gagcaagaaa gtctcttcgg cctcgggctt cctggagaag   6540

gggacgtcca ttcctgctgg gtcttaacaa gcataaaaag gaaaaaaagg aaactcaggc   6600

aaagggatcc atatgtgcaa tggcaaagaa atgtgaaaag gcattgggag aagcagtctg   6660

ggggaggcca gcccagtgcg ggcacagcac aacacgggga gcagcaagag atgagccagg   6720

gtccaggaga cagatgccca tcgcgagtac agactttgtc ctattggcaa caaggagtcc   6780

atggagcttt agagagatgc actcagcttc gtgttggcca agactccttc tgggccaatg   6840

gggctgcctc ttttcctttc atcagacact gtgaaaacat tcccttaagc gtgcactttt   6900

taatatcaca tctatttgtc tgtctgctca ttgttttgtt gctggaacta aatatgcaat   6960

ggatcatgag actcagattc tatgagaaac ccagggtctc tgctttacca cggagcaggg   7020

tcaccaaccc agatctccag gcccatgagg atggaacatg aaaggagccg acaaaagttg   7080

cttccattgg catgggctct ggagctgtcc agaagtccag ggacaccaga cttgatcaag   7140

gaagggctgt cactttagag gttcaaaagg aagtgcctca aagcaaaggc aagcaaagga   7200

accccacgat gaacttgctc ttttcctttg atgagcctct ccccaggtgt atttcagcag   7260

accccgggga cccaccccca ctgggcctgc tggcctccct cggctccagc ccaatgcccc   7320

agctggcctt ccccagcctg caaggagcct gtagcatggc aaatctgcct gctgtatgct   7380

attttcttag atcttggtac atccagacag gatgagggtg gagggagagc tatttaacac   7440

aaatcctaag atttttttct gctcaggaag gggtgaaata gctggcagat acaaaagaca   7500

gtggctttta tcattttaaa tggtaggaat ttaaggtgtg acttcaggga gaaacaaact   7560

tgcaaaaaaa aaaaatctca ggccatgttg gggtaaccca gcaagggcca gtgatgattt   7620

cccccagctc atccccttat tttcccacaa cccaaccatt ctctaaagca ggacagtgaa   7680

taggtcttag gccagtgcac acaggaagaa attgaggctt atggatgggg atgacttccc   7740

taagatccca tgggacaagg atgtggcaag gcttggatga gatggggcac cagtgcccag   7800

gaatttgaac attttccttt acccaggaaa tctccggagc caacaccacc acccccaggg   7860

ggtctcccca ccccacccca tttacagggt gagctcagcc tgtcatgagc agaggaaaat   7920

attattaatg ctctctgagt ctttacaaca ggagctctta cctcatagat gtgggctctg   7980

tttggggaag atgcaaggaa gtaatgagaa gcccaggaaa tttctccacc tgtgtttatg   8040

gcctaaatag cttcaggatg tatcttagct gcactccaac attgcatcct ttctggggtg   8100

aagaatctgg gccaaccagg ggtccttggg cctctagaag gccacagtag gcctctcttt   8160

gtgggaatgg aaggggacag tttgctttta gtgctggccc tctctgtggg tgtggcctgc   8220

aaaggaacca acagacccta tgctggggac tctaacatgt gagctcatta aattcttcca   8280

gcattctaaa ggagggtttg tgattgtcac catttactga tgaggaaact aaggctccta   8340

ggggagaaat cacttgccca cagttccaca gctagtgagt gaatgaacca ggatttaaac   8400

cggttttttc tcactacaga gacaatattt ttccaccatt gtatctcaca tttttcccag   8460

gaggttaccc ataacagaag agactagagt ggaacagata cgtcagtgga taaagctcaa   8520

agcaaacaac agtaagctta aaattccttc atagtctcat gttttacgtt cacaattcat   8580

gcaaaatttg cattccactt tctgatttag ccttgttggt tttaatatga ctctatgaat   8640

atttcaaaaa aaaatgtgct ctgttcctca tgttgttctg ttctgttcac cccgctatga   8700

cggaccctag gtcagctggt cttcagcttg accctagaat tgactctagg agcagtgacc   8760

ctgctgcctc ccagagccag ttataggctc aagatcaaga ccaactgacc ttctcctagg   8820

cagctccttt ggtgtgtggg tgctctgacc tcactgttca tgaggggacc tcaactaagg   8880

catcttccag ttgggtgctg gaaggaaccc attaactcac actagaatga tgaggatttg   8940

ctcatctggc gtggagaagg atgagcccac aaaaccctaa agggaaaaga gaagctggac   9000

acagctgtac tcagcagatt cctgaatgct aggctggaaa gtggtgcctg ttgtccaagt   9060

ggagtcacat ggttgctaat gtgggcaagt ctgaggacac acttcatgag cagctggggt   9120

ctggaaggct cctcacttta ccctagccac acataattac tgggtgccta cagcacctag   9180

caccttggag ggggcactat taggaaatcg agattactat ggcacaatta attcctgggt   9240

aaggcatggg gttgtggtgg acagagctca gtctttagtt tgaacgaaaa catacataca   9300

tgaaaaacat acatgaaaaa aggaccctca tcaacattag aaggggtaga tttggagcac   9360

tttaggcagg aaaacaggaa cgcaaggcca ggaaactgga acccagtgaa tactcagaac   9420

cgaggatgca gatgacttat ttagcaaaat ggtcacttct gtgacatagc tggagaaagg   9480

atgggtaaca gcttgccaga gccacttgga acaagggcaa atctcagtgt ctggggcaaa   9540

agatgatgca tttccctctg acccatcatg tttattcatc ctccactccc cattgccaca   9600

ctagctcttg ctgtaagtcc tcaccaggat ctacatttcc tcgtcgctgg tgggaacccc   9660

ttagagtaca tagaggtatc agtccagtaa gactgctcta cacaacagaa gtgaggccca   9720

gggagtagca gccaggccct tatcctgtta cctctgcagg agtgactgcc caacccagat   9780

ccagagacat tgaaggaaat gataattcct tggtacctca ctgccttggg acaaaatgaa   9840

gaaagccacc cttccttagg ctgcagcttg ccactcctgg gctgggtaaa caggtcatca   9900

gcaccaagct caaccaggag taacactctg gaagacatgg gtgagcccaa gaggaagcat   9960

gaacaggacg ctgttcctaa gtcatgtcaa caggttgtgc tgggccagga tccccaggga  10020

aaaaaatggt caacccaact ggagggtagg ttagaagaaa aaaaacataa acgtggatag  10080

tcatgtcatc tcaaatccct gacttggctt ccccattact taacagtctg agctccttct  10140

tagcctgtga ccagcttcaa atcacagcca agtaaaacaa ggaaatagga aaagtaaatc  10200

caactagaag agacaagctg agattcagat ttgtttactc ctcccatgca aagtttccct  10260

gttggaggtt ttccatgtat acatgtctag aagtgataga atgcaaggcc ttggctttgt  10320

cttgcaggga tctgcctttg aggtcataga ctgaacagca gggagagagg ttagtggtgg  10380

agtgtggggg gagctgttct agctccagtt tcttctgaca catttttcag gatcatggat  10440

ctgatcctcc gaagcacagc agagatatct aagccatatt tgtgcacatg agcagactct  10500

tctagttttt tagtaaccag ggatgggctt ttgcatggca ctgactatag agatgtcttg  10560

tagagatcaa gccagtcttt tgcatcccac ctgcccacct ccagaagaga tgggaaaagg  10620

tcatcaaagg gcattcacca actgaaatcc actcatgaat gttaggtctc taaaaggagg  10680

catcaacact cacaatggta gcctccaaac ctagcatccc acctatctaa gagctcaggg  10740

gtggtccact ggggcagata caagggaagt gcaagggctc aggatgaaag aaaatctatt  10800

gggaagagtt ttaggggctt gatcattatg gggcttcctt ctatatctga gaactgctct  10860

gggtggtgag atgtggactc tgatccttaa ttggaatgtt cggagaatga gtgtctggtg  10920

gccttgaagt gttggacaga aaagtatcag tataaaagcc tggagctcag ggtaattaat  10980

gtagttcatg gttccttagt gagcaggact cttggatgtg gaggagaaag ggtcatagga  11040

agtaaaccac caaaattaca aaattgagtc tctgtacaat tacttcagtg cctttgggct  11100

tatgaataca aatcagtggg ccttctctat gatggtccaa caaactctca gtgtccaccc  11160

tgtccctgta tctcccatgg aagatgaata atgtcaggtg ttctttgggt caaaggcccc  11220

agggcagtct ggaggcttag agggcagagt ggtgtcattc catgtaaagt taggcttctg  11280

aggggtcagg cagaatatgg tgtccatatc ttccatagct ctgcagattc ttggatgaag  11340

tcaagcacag tttgctagac ccaggtcact cctctgagta taactaggac ccatgagtga  11400

aacttaatag ctgtaaggaa gaacctgctg tctgccagag aggataagct gcccatctca  11460

gcagctgtct aaaagaaggc aggtgtctct ttaaagggaa gagaagcatt ggtgaaatgg  11520

atttcaggtc acttccattc cagatgggtg agatcttgtg gagctgggat catgtttgaa  11580

ctcattcata cctgtagagc acgaatccaa gtagattgtg tttggtctgt acaggctgaa  11640

gccccctgct ctcccaccca agtgccccca ctgagcaggc caacatgctg ttgtggccac  11700

atatactggg ctgatccagg ctggttatca ccaaacagca aaccataggg aacagctgct  11760

ttgccataga cccaataccc atgtagatct ctcatgagag cagccataac tcagacccac  11820

tgaccaacag ggccatgagt gacagccaga accagtgaag gtccaagtag gacacagagc  11880

agggcttttc ttaccataca cattatctcc agaggttatt tctaccccac tccctattca  11940

aggcctgttg gagcacactg caaaagcaaa agcacagtaa ctcaatttac acatgattat  12000

aatcatttcc agtgcacaca tttcatcacc aggtggatcc tgagctagcc catgtaaatc  12060

cgggttaacc catattggta atcatactca aaagcacttt tcaccctaca ttctactagc  12120

caatcaaaga caaagagttg tggcctctac cattgccttg gcttctggac accctcacaa  12180

gctatcccaa ggttcccgct caactccagg gaggctgaca tcttcacatc cactgggcat  12240

ataatattgc atgagaccaa agtctccaca ctctttgcag cctcctccat gaatcccaat  12300

ggcctgcact tgtacagttt gggtgtttga tagataaagc acgtatgaga agagaaaaca  12360

aaataaatca actttttaaa aaagccagca ctgtgctgtc aatgtttttt ttttcttttc  12420

aattctagct cagaaaagca gaaggtaaat aatgtcaggt caatgaatat cagatatatt  12480

ttttgactgt acattacagt gaagtgtaat ctttttacac ctgcaagtcc atcttattta  12540

ttcttgtaaa tgttccctga caatgtttgt aatatggctg tgttaaaaaa tctatacaat  12600

aaagctgtga ccctgagatt catgttttcc taagataaaa aaaa                   12644


<210>  541
<211>  1441
<212>  PRT
<213>  Homo sapiens

<400>  541


Met Ala Ser Leu Ala Ala Leu Ala Leu Ser Leu Leu Leu Arg Leu Gln 
1               5                   10                  15      


Leu Pro Pro Leu Pro Gly Ala Arg Ala Gln Ser Ala Ala Gly Gly Cys 
            20                  25                  30          


Ser Phe Asp Glu His Tyr Ser Asn Cys Gly Tyr Ser Val Ala Leu Gly 
        35                  40                  45              


Thr Asn Gly Phe Thr Trp Glu Gln Ile Asn Thr Trp Glu Lys Pro Met 
    50                  55                  60                  


Leu Asp Gln Ala Val Pro Thr Gly Ser Phe Met Met Val Asn Ser Ser 
65                  70                  75                  80  


Gly Arg Ala Ser Gly Gln Lys Ala His Leu Leu Leu Pro Thr Leu Lys 
                85                  90                  95      


Glu Asn Asp Thr His Cys Ile Asp Phe His Tyr Tyr Phe Ser Ser Arg 
            100                 105                 110         


Asp Arg Ser Ser Pro Gly Ala Leu Asn Val Tyr Val Lys Val Asn Gly 
        115                 120                 125             


Gly Pro Gln Gly Asn Pro Val Trp Asn Val Ser Gly Val Val Thr Glu 
    130                 135                 140                 


Gly Trp Val Lys Ala Glu Leu Ala Ile Ser Thr Phe Trp Pro His Phe 
145                 150                 155                 160 


Tyr Gln Val Ile Phe Glu Ser Val Ser Leu Lys Gly His Pro Gly Tyr 
                165                 170                 175     


Ile Ala Val Asp Glu Val Arg Val Leu Ala His Pro Cys Arg Lys Ala 
            180                 185                 190         


Pro His Phe Leu Arg Leu Gln Asn Val Glu Val Asn Val Gly Gln Asn 
        195                 200                 205             


Ala Thr Phe Gln Cys Ile Ala Gly Gly Lys Trp Ser Gln His Asp Lys 
    210                 215                 220                 


Leu Trp Leu Gln Gln Trp Asn Gly Arg Asp Thr Ala Leu Met Val Thr 
225                 230                 235                 240 


Arg Val Val Asn His Arg Arg Phe Ser Ala Thr Val Ser Val Ala Asp 
                245                 250                 255     


Thr Ala Gln Arg Ser Val Ser Lys Tyr Arg Cys Val Ile Arg Ser Asp 
            260                 265                 270         


Gly Gly Ser Gly Val Ser Asn Tyr Ala Glu Leu Ile Val Lys Glu Pro 
        275                 280                 285             


Pro Thr Pro Ile Ala Pro Pro Glu Leu Leu Ala Val Gly Ala Thr Tyr 
    290                 295                 300                 


Leu Trp Ile Lys Pro Asn Ala Asn Ser Ile Ile Gly Asp Gly Pro Ile 
305                 310                 315                 320 


Ile Leu Lys Glu Val Glu Tyr Arg Thr Thr Thr Gly Thr Trp Ala Glu 
                325                 330                 335     


Thr His Ile Val Asp Ser Pro Asn Tyr Lys Leu Trp His Leu Asp Pro 
            340                 345                 350         


Asp Val Glu Tyr Glu Ile Arg Val Leu Leu Thr Arg Pro Gly Glu Gly 
        355                 360                 365             


Gly Thr Gly Pro Pro Gly Pro Pro Leu Thr Thr Arg Thr Lys Cys Ala 
    370                 375                 380                 


Asp Pro Val His Gly Pro Gln Asn Val Glu Ile Val Asp Ile Arg Ala 
385                 390                 395                 400 


Arg Gln Leu Thr Leu Gln Trp Glu Pro Phe Gly Tyr Ala Val Thr Arg 
                405                 410                 415     


Cys His Ser Tyr Asn Leu Thr Val Gln Tyr Gln Tyr Val Phe Asn Gln 
            420                 425                 430         


Gln Gln Tyr Glu Ala Glu Glu Val Ile Gln Thr Ser Ser His Tyr Thr 
        435                 440                 445             


Leu Arg Gly Leu Arg Pro Phe Met Thr Ile Arg Leu Arg Leu Leu Leu 
    450                 455                 460                 


Ser Asn Pro Glu Gly Arg Met Glu Ser Glu Glu Leu Val Val Gln Thr 
465                 470                 475                 480 


Glu Glu Asp Val Pro Gly Ala Val Pro Leu Glu Ser Ile Gln Gly Gly 
                485                 490                 495     


Pro Phe Glu Glu Lys Ile Tyr Ile Gln Trp Lys Pro Pro Asn Glu Thr 
            500                 505                 510         


Asn Gly Val Ile Thr Leu Tyr Glu Ile Asn Tyr Lys Ala Val Gly Ser 
        515                 520                 525             


Leu Asp Pro Ser Ala Asp Leu Ser Ser Gln Arg Gly Lys Val Phe Lys 
    530                 535                 540                 


Leu Arg Asn Glu Thr His His Leu Phe Val Gly Leu Tyr Pro Gly Thr 
545                 550                 555                 560 


Thr Tyr Ser Phe Thr Ile Lys Ala Ser Thr Ala Lys Gly Phe Gly Pro 
                565                 570                 575     


Pro Val Thr Thr Arg Ile Ala Thr Lys Ile Ser Ala Pro Ser Met Pro 
            580                 585                 590         


Glu Tyr Asp Thr Asp Thr Pro Leu Asn Glu Thr Asp Thr Thr Ile Thr 
        595                 600                 605             


Val Met Leu Lys Pro Ala Gln Ser Arg Gly Ala Pro Val Ser Val Tyr 
    610                 615                 620                 


Gln Leu Val Val Lys Glu Glu Arg Leu Gln Lys Ser Arg Arg Ala Ala 
625                 630                 635                 640 


Asp Ile Ile Glu Cys Phe Ser Val Pro Val Ser Tyr Arg Asn Ala Ser 
                645                 650                 655     


Ser Leu Asp Ser Leu His Tyr Phe Ala Ala Glu Leu Lys Pro Ala Asn 
            660                 665                 670         


Leu Pro Val Thr Gln Pro Phe Thr Val Gly Asp Asn Lys Thr Tyr Asn 
        675                 680                 685             


Gly Tyr Trp Asn Pro Pro Leu Ser Pro Leu Lys Ser Tyr Ser Ile Tyr 
    690                 695                 700                 


Phe Gln Ala Leu Ser Lys Ala Asn Gly Glu Thr Lys Ile Asn Cys Val 
705                 710                 715                 720 


Arg Leu Ala Thr Lys Gly Ala Ser Thr Gln Asn Ser Asn Thr Val Glu 
                725                 730                 735     


Pro Glu Lys Gln Val Asp Asn Thr Val Lys Met Ala Gly Val Ile Ala 
            740                 745                 750         


Gly Leu Leu Met Phe Ile Ile Ile Leu Leu Gly Val Met Leu Thr Ile 
        755                 760                 765             


Lys Arg Arg Arg Asn Ala Tyr Ser Tyr Ser Tyr Tyr Leu Lys Leu Ala 
    770                 775                 780                 


Lys Lys Gln Lys Glu Thr Gln Ser Gly Ala Gln Arg Glu Met Gly Pro 
785                 790                 795                 800 


Val Ala Ser Ala Asp Lys Pro Thr Thr Lys Leu Ser Ala Ser Arg Asn 
                805                 810                 815     


Asp Glu Gly Phe Ser Ser Ser Ser Gln Asp Val Asn Gly Phe Thr Asp 
            820                 825                 830         


Gly Ser Arg Gly Glu Leu Ser Gln Pro Thr Leu Thr Ile Gln Thr His 
        835                 840                 845             


Pro Tyr Arg Thr Cys Asp Pro Val Glu Met Ser Tyr Pro Arg Asp Gln 
    850                 855                 860                 


Phe Gln Pro Ala Ile Arg Val Ala Asp Leu Leu Gln His Ile Thr Gln 
865                 870                 875                 880 


Met Lys Arg Gly Gln Gly Tyr Gly Phe Lys Glu Glu Tyr Glu Ala Leu 
                885                 890                 895     


Pro Glu Gly Gln Thr Ala Ser Trp Asp Thr Ala Lys Glu Asp Glu Asn 
            900                 905                 910         


Arg Asn Lys Asn Arg Tyr Gly Asn Ile Ile Ser Tyr Asp His Ser Arg 
        915                 920                 925             


Val Arg Leu Leu Val Leu Asp Gly Asp Pro His Ser Asp Tyr Ile Asn 
    930                 935                 940                 


Ala Asn Tyr Ile Asp Gly Tyr His Arg Pro Arg His Tyr Ile Ala Thr 
945                 950                 955                 960 


Gln Gly Pro Met Gln Glu Thr Val Lys Asp Phe Trp Arg Met Ile Trp 
                965                 970                 975     


Gln Glu Asn Ser Ala Ser Ile Val Met Val Thr Asn Leu Val Glu Val 
            980                 985                 990         


Gly Arg Val Lys Cys Val Arg Tyr  Trp Pro Asp Asp Thr  Glu Val Tyr 
        995                 1000                 1005             


Gly Asp  Ile Lys Val Thr Leu  Ile Glu Thr Glu Pro  Leu Ala Glu 
    1010                 1015                 1020             


Tyr Val  Ile Arg Thr Phe Thr  Val Gln Lys Lys Gly  Tyr His Glu 
    1025                 1030                 1035             


Ile Arg  Glu Leu Arg Leu Phe  His Phe Thr Ser Trp  Pro Asp His 
    1040                 1045                 1050             


Gly Val  Pro Cys Tyr Ala Thr  Gly Leu Leu Gly Phe  Val Arg Gln 
    1055                 1060                 1065             


Val Lys  Phe Leu Asn Pro Pro  Glu Ala Gly Pro Ile  Val Val His 
    1070                 1075                 1080             


Cys Ser  Ala Gly Ala Gly Arg  Thr Gly Cys Phe Ile  Ala Ile Asp 
    1085                 1090                 1095             


Thr Met  Leu Asp Met Ala Glu  Asn Glu Gly Val Val  Asp Ile Phe 
    1100                 1105                 1110             


Asn Cys  Val Arg Glu Leu Arg  Ala Gln Arg Val Asn  Leu Val Gln 
    1115                 1120                 1125             


Thr Glu  Glu Gln Tyr Val Phe  Val His Asp Ala Ile  Leu Glu Ala 
    1130                 1135                 1140             


Cys Leu  Cys Gly Asn Thr Ala  Ile Pro Val Cys Glu  Phe Arg Ser 
    1145                 1150                 1155             


Leu Tyr  Tyr Asn Ile Ser Arg  Leu Asp Pro Gln Thr  Asn Ser Ser 
    1160                 1165                 1170             


Gln Ile  Lys Asp Glu Phe Gln  Thr Leu Asn Ile Val  Thr Pro Arg 
    1175                 1180                 1185             


Val Arg  Pro Glu Asp Cys Ser  Ile Gly Leu Leu Pro  Arg Asn His 
    1190                 1195                 1200             


Asp Lys  Asn Arg Ser Met Asp  Val Leu Pro Leu Asp  Arg Cys Leu 
    1205                 1210                 1215             


Pro Phe  Leu Ile Ser Val Asp  Gly Glu Ser Ser Asn  Tyr Ile Asn 
    1220                 1225                 1230             


Ala Ala  Leu Met Asp Ser His  Lys Gln Pro Ala Ala  Phe Val Val 
    1235                 1240                 1245             


Thr Gln  His Pro Leu Pro Asn  Thr Val Ala Asp Phe  Trp Arg Leu 
    1250                 1255                 1260             


Val Phe  Asp Tyr Asn Cys Ser  Ser Val Val Met Leu  Asn Glu Met 
    1265                 1270                 1275             


Asp Thr  Ala Gln Phe Cys Met  Gln Tyr Trp Pro Glu  Lys Thr Ser 
    1280                 1285                 1290             


Gly Cys  Tyr Gly Pro Ile Gln  Val Glu Phe Val Ser  Ala Asp Ile 
    1295                 1300                 1305             


Asp Glu  Asp Ile Ile His Arg  Ile Phe Arg Ile Cys  Asn Met Ala 
    1310                 1315                 1320             


Arg Pro  Gln Asp Gly Tyr Arg  Ile Val Gln His Leu  Gln Tyr Ile 
    1325                 1330                 1335             


Gly Trp  Pro Ala Tyr Arg Asp  Thr Pro Pro Ser Lys  Arg Ser Leu 
    1340                 1345                 1350             


Leu Lys  Val Val Arg Arg Leu  Glu Lys Trp Gln Glu  Gln Tyr Asp 
    1355                 1360                 1365             


Gly Arg  Glu Gly Arg Thr Val  Val His Cys Leu Asn  Gly Gly Gly 
    1370                 1375                 1380             


Arg Ser  Gly Thr Phe Cys Ala  Ile Cys Ser Val Cys  Glu Met Ile 
    1385                 1390                 1395             


Gln Gln  Gln Asn Ile Ile Asp  Val Phe His Ile Val  Lys Thr Leu 
    1400                 1405                 1410             


Arg Asn  Asn Lys Ser Asn Met  Val Glu Thr Leu Glu  Gln Tyr Lys 
    1415                 1420                 1425             


Phe Val  Tyr Glu Val Ala Leu  Glu Tyr Leu Ser Ser  Phe 
    1430                 1435                 1440     

<210>  542
<211>  12701
<212>  DNA
<213>  Homo sapiens

<400>  542
cctcccgcct cagttcgcgc cgcgcctcgg cttggaacgc aggagcgccg gctccgggag     60

cccgagcgga gccagccgcg cgcacagcca gcggccgcgc cggcgatgcg gggccacccc    120

gcgcccgccc cagtcccggc cccggccccc gcgggaaggg gctgagctgc ccgccgccgc    180

ccggatggcg agcctcgccg cgctcgccct cagcctgctc ctgaggctgc agctgccgcc    240

actgcccggc gcccgggctc agagcgccgc aggtggctgt tcctttgatg agcactacag    300

caactgtggt tatagtgtgg ctctagggac caatgggttc acctgggagc agattaacac    360

atgggagaaa ccaatgctgg accaggcagt gcccacagga tctttcatga tggtgaacag    420

ctctgggaga gcctctggcc agaaggccca ccttctcctg ccaaccctga aggagaatga    480

cacccactgc atcgacttcc attactactt ctccagccgt gacaggtcca gcccaggggc    540

cttgaacgtc tacgtgaagg tgaatggtgg cccccaaggg aaccctgtgt ggaatgtgtc    600

cggggtcgtc actgagggct gggtgaaggc agagctcgcc atcagcactt tctggccaca    660

tttctatcag gtgatatttg aatccgtctc attgaagggt catcctggct acatcgccgt    720

ggacgaggtc cgggtccttg ctcatccatg cagaaaagca cctcattttc tgcgactcca    780

aaacgtggag gtgaatgtgg ggcagaatgc cacatttcag tgcattgctg gtgggaagtg    840

gtctcagcat gacaagcttt ggctccagca atggaatggc agggacacgg ccctgatggt    900

cacccgtgtg gtcaaccaca ggcgcttctc agccacagtc agtgtggcag acactgccca    960

gcggagcgtc agcaagtacc gctgtgtgat ccgctctgat ggtgggtctg gtgtgtccaa   1020

ctacgcggag ctgatcgtga aagagcctcc cacgcccatt gctcccccag agctgctggc   1080

tgtgggggcc acatacctgt ggatcaagcc aaatgccaac tccatcatcg gggatggccc   1140

catcatcctg aaggaagtgg aatatcgcac caccacaggc acgtgggcag agacccacat   1200

agtcgactct cccaactata agctgtggca tctggacccc gatgttgagt atgagatccg   1260

agtgctcctc acacgaccag gtgagggggg tacgggaccg ccagggcctc ccctcaccac   1320

caggaccaag tgtgcagatc cggtacatgg cccacagaac gtggaaatcg tagacatcag   1380

agcccggcag ctgaccctgc agtgggagcc cttcggctac gcggtgaccc gctgccatag   1440

ctacaacctc accgtgcagt accagtatgt gttcaaccag cagcagtacg aggccgagga   1500

ggtcatccag acctcctccc actacaccct gcgaggcctg cgccccttca tgaccatccg   1560

gctgcgactc ttgctgtcta accccgaggg ccgaatggag agcgaggagc tggtggtgca   1620

gactgaggaa gacgttccag gagctgttcc tctagaatcc atccaagggg ggccctttga   1680

ggagaagatc tacatccagt ggaaacctcc caatgagacc aatggggtca tcacgctcta   1740

cgagatcaac tacaaggctg tcggctcgct ggacccaagt gctgacctct cgagccagag   1800

ggggaaagtg ttcaagctcc ggaatgaaac ccaccacctc tttgtgggtc tgtacccagg   1860

gaccacctat tccttcacca tcaaggccag cacagcaaag ggctttgggc cccctgtcac   1920

cactcggatt gccaccaaaa tttcagctcc atccatgcct gagtacgaca cagacacccc   1980

attgaatgag acagacacga ccatcacagt gatgctgaaa cccgctcagt cccggggagc   2040

tcctgtcagt gtttatcagc tggttgtcaa ggaggagcga cttcagaagt cacggagggc   2100

agctgacatt attgagtgct tttcggtgcc cgtgagctat cggaatgcct ccagcctcga   2160

ttctctacac tactttgctg ctgagttgaa gcctgccaac ctgcctgtca cccagccatt   2220

tacagtgggt gacaataaga catacaatgg ctactggaac cctcctctct ctcccctgaa   2280

aagctacagc atctacttcc aggcactcag caaagccaat ggagagacca aaatcaactg   2340

tgttcgtctg gctacaaaag caccaatggg cagcgcccag gtgaccccgg ggactccact   2400

ctgcctcctc accacaggtg cctccaccca gaattctaac actgtggagc cagagaagca   2460

ggtggacaac accgtgaaga tggctggcgt gatcgctggc ctcctcatgt tcatcatcat   2520

tctcctgggc gtgatgctca ccatcaaaag gagaagaaat gcttattcct actcctatta   2580

cttgaagctg gccaagaagc agaaggagac ccagagtgga gcccagaggg agatggggcc   2640

tgtggcctct gccgacaaac ccaccaccaa gctcagcgcc agccgcaatg atgaaggctt   2700

ctcttctagt tctcaggacg tcaacggatt cacagatggc agccgcgggg agctttccca   2760

gcccaccctc acgatccaga ctcatcccta ccgcacctgt gaccctgtgg agatgagcta   2820

cccccgggac cagttccaac ccgccatccg ggtggctgac ttgctgcagc acatcacgca   2880

gatgaagaga ggccagggct acgggttcaa ggaggaatac gaggccttac cagaggggca   2940

gacagcttcg tgggacacag ccaaggagga tgaaaaccgc aataagaatc gatatgggaa   3000

catcatatcc tacgaccatt cccgggtgag gctgctggtg ctggatggag acccgcactc   3060

tgactacatc aatgccaact acattgacgg ataccatcga cctcggcact acattgcgac   3120

tcaaggtccg atgcaggaga ctgtaaagga cttttggaga atgatctggc aggagaactc   3180

cgccagcatc gtcatggtca caaacctggt ggaagtgggc agggtgaaat gtgtgcgata   3240

ctggccagat gacacggagg tctacggaga cattaaagtc accctgattg aaacagagcc   3300

cctggcagaa tacgtcatac gcaccttcac agtccagaag aaaggctacc atgagatccg   3360

ggagctccgc ctcttccact tcaccagctg gcctgaccac ggcgttccct gctatgccac   3420

tggccttctg ggcttcgtcc gccaggtcaa gttcctcaac cccccggaag ctgggcccat   3480

agtggtccac tgcagtgctg gggctgggcg gactggctgc ttcattgcca ttgacaccat   3540

gcttgacatg gccgagaatg aaggggtggt ggacatcttc aactgcgtgc gtgagctccg   3600

ggcccaaagg gtcaacctgg tacagacaga ggagcaatat gtgtttgtgc acgatgccat   3660

cctggaagcg tgcctctgtg gcaacactgc catccctgtg tgtgagttcc gttctctcta   3720

ctacaatatc agcaggctgg acccccagac aaactccagc caaatcaaag atgaatttca   3780

gaccctcaac attgtgacac cccgtgtgcg gcccgaggac tgcagcattg ggctcctgcc   3840

ccggaaccat gataagaatc gaagtatgga cgtgctgcct ctggaccgct gcctgccctt   3900

ccttatctca gtggacggag aatccagcaa ttacatcaac gcagcactga tggatagcca   3960

caagcagcct gccgccttcg tggtcaccca gcaccctcta cccaacaccg tggcagactt   4020

ctggaggctg gtgttcgatt acaactgctc ctctgtggtg atgctgaatg agatggacac   4080

tgcccagttc tgtatgcagt actggcctga gaagacctcc gggtgctatg ggcccatcca   4140

ggtggagttc gtctccgcag acatcgacga ggacatcatc cacagaatat tccgcatctg   4200

taacatggcc cggccacagg atggttatcg tatagtccag cacctccagt acattggctg   4260

gcctgcctac cgggacacgc ccccctccaa gcgctctctg ctcaaagtgg tccgacgact   4320

ggagaagtgg caggagcagt atgacgggag ggagggacgt actgtggtcc actgcctaaa   4380

tgggggaggc cgtagtggaa ccttctgtgc catctgcagt gtgtgtgaga tgatccagca   4440

gcaaaacatc attgacgtgt tccacatcgt gaaaacactg cgtaacaaca aatccaacat   4500

ggtggagacc ctggaacagt ataaatttgt atacgaggtg gcactggaat atttaagctc   4560

cttttagctc aatgggatgg ggaacctgcc ggagtccaga ggctgctgtg accaagcccc   4620

cttttgtgtg aatggcagta actgggctca ggagctctga ggtggcaccc tgcctgactc   4680

caaggagaag actggtggcc ctgtgttcca cggggggctc tgcaccttct gaggggtctc   4740

ctgttgccgt gggagatgct gctccaaaag gcccaggctt ccttttcaac ctaaccagcc   4800

acagccaagg gcccaagcag aagtacaccc acaagcaagg ccttggattt ctggctccca   4860

gaccacctgc ttttgttctg agtttgtgga tctcttggca agccaactgt gcaggtgctg   4920

gggagtggga ggctcccctg ccctccttct ccttaggagt ggaggagatg tgtgttctgc   4980

tcctctacgt catggaaaag attgaggctc ttgggggtca ctgctctgct gccccctgca   5040

acctccttca ggggcctctg gcaccagaca tttgcagtct ggaccagtgt gaccttacga   5100

tgttccctag gccacaagag aggcccccca tcctcacacc taacctgcat ggggcttcgc   5160

ccacaaccat tctgtacccc ttccccagcc tgggccttga ccgtccagca ttcactggcc   5220

ggccagctgt gtccacagca gtttttgata aaggtgttct ttgctttttt gtgtggtcag   5280

tgggaggggg tggaactgca gggaacttct ctgctcctcc ttgtctttgt aaaaagggac   5340

cacctccctg gggcagggct tgggctgacc tgtaggatgt aacccctgtg tttctttggt   5400

ggtagctttc tttggaagag acaaacaaga taagatttga ttattttcca aagtgtatgt   5460

gaaaagaaac tttcttttgg agggtgtaaa atcttagtct cttatgtcaa aaagaagggg   5520

gcgggggagt ttgagtatgt acctctaaga caaatctctc gggcctttta ttttttcctg   5580

gcaatgtcct taaaagctcc caccctggga cagcatgcca ctgagcaagg agagatgggt   5640

gagcctgaag atggtccctt tggtttctgg ggcaaataga gcaccagctt tgtgcataat   5700

ttggatgtcc aaatttgaac tccttcctaa agaaacccag cagccacctt gaaaaaggcc   5760

attgtggagc ccattatact ttgatttaaa ataggccaag agaatcaggc ctggagatct   5820

agggtcttgt ccaaagtgtg agtgagtcaa tgagagggaa ccaacatttg ctaagtctct   5880

actgtatgcc agggatcatg cttggcactt tccataggac atttcacaca gtccttagaa   5940

cccccaggag agagctactg acttgttatc atctccattt gatcatctcc tccaatgagg   6000

aaacccacgc accttcctta gtaatgaaat cctgggttcc aaaggggcag gtaatggcaa   6060

tgagacttct ccgtgctgtt ttcttcatct tctctaagcc aagcaattat tttatggagg   6120

gaaaataagg ccagaaactt ctgagcagat aactccacaa atggaaattt agtactttct   6180

tcctgatgcc agttcttctg ggaagcgcag aatttcagat atattttagt aacacattcc   6240

cagctcccca ggaaagccag tctcatctaa tttcttagtc agtaaaaaca attccctgtt   6300

ccttcaggct atgaatggac cagccaggga aactctcgac cttgatctct agccagtgct   6360

taggcccaat atctgacagc ctcaggtggg ctgggaccta ggaagctcca tcttgaaggc   6420

tggtctagcc ccagacaggg catgaggggc agagaattca agaaggtaca gctttggccc   6480

tcaagagccc actgtatgct ggggaaatgg aaccatggtg cagtagtgtg gagtggatga   6540

gtgttccatg agcctaggag caagaaagtc tcttcggcct cgggcttcct ggagaagggg   6600

acgtccattc ctgctgggtc ttaacaagca taaaaaggaa aaaaaggaaa ctcaggcaaa   6660

gggatccata tgtgcaatgg caaagaaatg tgaaaaggca ttgggagaag cagtctgggg   6720

gaggccagcc cagtgcgggc acagcacaac acggggagca gcaagagatg agccagggtc   6780

caggagacag atgcccatcg cgagtacaga ctttgtccta ttggcaacaa ggagtccatg   6840

gagctttaga gagatgcact cagcttcgtg ttggccaaga ctccttctgg gccaatgggg   6900

ctgcctcttt tcctttcatc agacactgtg aaaacattcc cttaagcgtg cactttttaa   6960

tatcacatct atttgtctgt ctgctcattg ttttgttgct ggaactaaat atgcaatgga   7020

tcatgagact cagattctat gagaaaccca gggtctctgc tttaccacgg agcagggtca   7080

ccaacccaga tctccaggcc catgaggatg gaacatgaaa ggagccgaca aaagttgctt   7140

ccattggcat gggctctgga gctgtccaga agtccaggga caccagactt gatcaaggaa   7200

gggctgtcac tttagaggtt caaaaggaag tgcctcaaag caaaggcaag caaaggaacc   7260

ccacgatgaa cttgctcttt tcctttgatg agcctctccc caggtgtatt tcagcagacc   7320

ccggggaccc acccccactg ggcctgctgg cctccctcgg ctccagccca atgccccagc   7380

tggccttccc cagcctgcaa ggagcctgta gcatggcaaa tctgcctgct gtatgctatt   7440

ttcttagatc ttggtacatc cagacaggat gagggtggag ggagagctat ttaacacaaa   7500

tcctaagatt tttttctgct caggaagggg tgaaatagct ggcagataca aaagacagtg   7560

gcttttatca ttttaaatgg taggaattta aggtgtgact tcagggagaa acaaacttgc   7620

aaaaaaaaaa aatctcaggc catgttgggg taacccagca agggccagtg atgatttccc   7680

ccagctcatc cccttatttt cccacaaccc aaccattctc taaagcagga cagtgaatag   7740

gtcttaggcc agtgcacaca ggaagaaatt gaggcttatg gatggggatg acttccctaa   7800

gatcccatgg gacaaggatg tggcaaggct tggatgagat ggggcaccag tgcccaggaa   7860

tttgaacatt ttcctttacc caggaaatct ccggagccaa caccaccacc cccagggggt   7920

ctccccaccc caccccattt acagggtgag ctcagcctgt catgagcaga ggaaaatatt   7980

attaatgctc tctgagtctt tacaacagga gctcttacct catagatgtg ggctctgttt   8040

ggggaagatg caaggaagta atgagaagcc caggaaattt ctccacctgt gtttatggcc   8100

taaatagctt caggatgtat cttagctgca ctccaacatt gcatcctttc tggggtgaag   8160

aatctgggcc aaccaggggt ccttgggcct ctagaaggcc acagtaggcc tctctttgtg   8220

ggaatggaag gggacagttt gcttttagtg ctggccctct ctgtgggtgt ggcctgcaaa   8280

ggaaccaaca gaccctatgc tggggactct aacatgtgag ctcattaaat tcttccagca   8340

ttctaaagga gggtttgtga ttgtcaccat ttactgatga ggaaactaag gctcctaggg   8400

gagaaatcac ttgcccacag ttccacagct agtgagtgaa tgaaccagga tttaaaccgg   8460

ttttttctca ctacagagac aatatttttc caccattgta tctcacattt ttcccaggag   8520

gttacccata acagaagaga ctagagtgga acagatacgt cagtggataa agctcaaagc   8580

aaacaacagt aagcttaaaa ttccttcata gtctcatgtt ttacgttcac aattcatgca   8640

aaatttgcat tccactttct gatttagcct tgttggtttt aatatgactc tatgaatatt   8700

tcaaaaaaaa atgtgctctg ttcctcatgt tgttctgttc tgttcacccc gctatgacgg   8760

accctaggtc agctggtctt cagcttgacc ctagaattga ctctaggagc agtgaccctg   8820

ctgcctccca gagccagtta taggctcaag atcaagacca actgaccttc tcctaggcag   8880

ctcctttggt gtgtgggtgc tctgacctca ctgttcatga ggggacctca actaaggcat   8940

cttccagttg ggtgctggaa ggaacccatt aactcacact agaatgatga ggatttgctc   9000

atctggcgtg gagaaggatg agcccacaaa accctaaagg gaaaagagaa gctggacaca   9060

gctgtactca gcagattcct gaatgctagg ctggaaagtg gtgcctgttg tccaagtgga   9120

gtcacatggt tgctaatgtg ggcaagtctg aggacacact tcatgagcag ctggggtctg   9180

gaaggctcct cactttaccc tagccacaca taattactgg gtgcctacag cacctagcac   9240

cttggagggg gcactattag gaaatcgaga ttactatggc acaattaatt cctgggtaag   9300

gcatggggtt gtggtggaca gagctcagtc tttagtttga acgaaaacat acatacatga   9360

aaaacataca tgaaaaaagg accctcatca acattagaag gggtagattt ggagcacttt   9420

aggcaggaaa acaggaacgc aaggccagga aactggaacc cagtgaatac tcagaaccga   9480

ggatgcagat gacttattta gcaaaatggt cacttctgtg acatagctgg agaaaggatg   9540

ggtaacagct tgccagagcc acttggaaca agggcaaatc tcagtgtctg gggcaaaaga   9600

tgatgcattt ccctctgacc catcatgttt attcatcctc cactccccat tgccacacta   9660

gctcttgctg taagtcctca ccaggatcta catttcctcg tcgctggtgg gaacccctta   9720

gagtacatag aggtatcagt ccagtaagac tgctctacac aacagaagtg aggcccaggg   9780

agtagcagcc aggcccttat cctgttacct ctgcaggagt gactgcccaa cccagatcca   9840

gagacattga aggaaatgat aattccttgg tacctcactg ccttgggaca aaatgaagaa   9900

agccaccctt ccttaggctg cagcttgcca ctcctgggct gggtaaacag gtcatcagca   9960

ccaagctcaa ccaggagtaa cactctggaa gacatgggtg agcccaagag gaagcatgaa  10020

caggacgctg ttcctaagtc atgtcaacag gttgtgctgg gccaggatcc ccagggaaaa  10080

aaatggtcaa cccaactgga gggtaggtta gaagaaaaaa aacataaacg tggatagtca  10140

tgtcatctca aatccctgac ttggcttccc cattacttaa cagtctgagc tccttcttag  10200

cctgtgacca gcttcaaatc acagccaagt aaaacaagga aataggaaaa gtaaatccaa  10260

ctagaagaga caagctgaga ttcagatttg tttactcctc ccatgcaaag tttccctgtt  10320

ggaggttttc catgtataca tgtctagaag tgatagaatg caaggccttg gctttgtctt  10380

gcagggatct gcctttgagg tcatagactg aacagcaggg agagaggtta gtggtggagt  10440

gtggggggag ctgttctagc tccagtttct tctgacacat ttttcaggat catggatctg  10500

atcctccgaa gcacagcaga gatatctaag ccatatttgt gcacatgagc agactcttct  10560

agttttttag taaccaggga tgggcttttg catggcactg actatagaga tgtcttgtag  10620

agatcaagcc agtcttttgc atcccacctg cccacctcca gaagagatgg gaaaaggtca  10680

tcaaagggca ttcaccaact gaaatccact catgaatgtt aggtctctaa aaggaggcat  10740

caacactcac aatggtagcc tccaaaccta gcatcccacc tatctaagag ctcaggggtg  10800

gtccactggg gcagatacaa gggaagtgca agggctcagg atgaaagaaa atctattggg  10860

aagagtttta ggggcttgat cattatgggg cttccttcta tatctgagaa ctgctctggg  10920

tggtgagatg tggactctga tccttaattg gaatgttcgg agaatgagtg tctggtggcc  10980

ttgaagtgtt ggacagaaaa gtatcagtat aaaagcctgg agctcagggt aattaatgta  11040

gttcatggtt ccttagtgag caggactctt ggatgtggag gagaaagggt cataggaagt  11100

aaaccaccaa aattacaaaa ttgagtctct gtacaattac ttcagtgcct ttgggcttat  11160

gaatacaaat cagtgggcct tctctatgat ggtccaacaa actctcagtg tccaccctgt  11220

ccctgtatct cccatggaag atgaataatg tcaggtgttc tttgggtcaa aggccccagg  11280

gcagtctgga ggcttagagg gcagagtggt gtcattccat gtaaagttag gcttctgagg  11340

ggtcaggcag aatatggtgt ccatatcttc catagctctg cagattcttg gatgaagtca  11400

agcacagttt gctagaccca ggtcactcct ctgagtataa ctaggaccca tgagtgaaac  11460

ttaatagctg taaggaagaa cctgctgtct gccagagagg ataagctgcc catctcagca  11520

gctgtctaaa agaaggcagg tgtctcttta aagggaagag aagcattggt gaaatggatt  11580

tcaggtcact tccattccag atgggtgaga tcttgtggag ctgggatcat gtttgaactc  11640

attcatacct gtagagcacg aatccaagta gattgtgttt ggtctgtaca ggctgaagcc  11700

ccctgctctc ccacccaagt gcccccactg agcaggccaa catgctgttg tggccacata  11760

tactgggctg atccaggctg gttatcacca aacagcaaac catagggaac agctgctttg  11820

ccatagaccc aatacccatg tagatctctc atgagagcag ccataactca gacccactga  11880

ccaacagggc catgagtgac agccagaacc agtgaaggtc caagtaggac acagagcagg  11940

gcttttctta ccatacacat tatctccaga ggttatttct accccactcc ctattcaagg  12000

cctgttggag cacactgcaa aagcaaaagc acagtaactc aatttacaca tgattataat  12060

catttccagt gcacacattt catcaccagg tggatcctga gctagcccat gtaaatccgg  12120

gttaacccat attggtaatc atactcaaaa gcacttttca ccctacattc tactagccaa  12180

tcaaagacaa agagttgtgg cctctaccat tgccttggct tctggacacc ctcacaagct  12240

atcccaaggt tcccgctcaa ctccagggag gctgacatct tcacatccac tgggcatata  12300

atattgcatg agaccaaagt ctccacactc tttgcagcct cctccatgaa tcccaatggc  12360

ctgcacttgt acagtttggg tgtttgatag ataaagcacg tatgagaaga gaaaacaaaa  12420

taaatcaact ttttaaaaaa gccagcactg tgctgtcaat gttttttttt tcttttcaat  12480

tctagctcag aaaagcagaa ggtaaataat gtcaggtcaa tgaatatcag atatattttt  12540

tgactgtaca ttacagtgaa gtgtaatctt tttacacctg caagtccatc ttatttattc  12600

ttgtaaatgt tccctgacaa tgtttgtaat atggctgtgt taaaaaatct atacaataaa  12660

gctgtgaccc tgagattcat gttttcctaa gataaaaaaa a                      12701


<210>  543
<211>  1460
<212>  PRT
<213>  Homo sapiens

<400>  543


Met Ala Ser Leu Ala Ala Leu Ala Leu Ser Leu Leu Leu Arg Leu Gln 
1               5                   10                  15      


Leu Pro Pro Leu Pro Gly Ala Arg Ala Gln Ser Ala Ala Gly Gly Cys 
            20                  25                  30          


Ser Phe Asp Glu His Tyr Ser Asn Cys Gly Tyr Ser Val Ala Leu Gly 
        35                  40                  45              


Thr Asn Gly Phe Thr Trp Glu Gln Ile Asn Thr Trp Glu Lys Pro Met 
    50                  55                  60                  


Leu Asp Gln Ala Val Pro Thr Gly Ser Phe Met Met Val Asn Ser Ser 
65                  70                  75                  80  


Gly Arg Ala Ser Gly Gln Lys Ala His Leu Leu Leu Pro Thr Leu Lys 
                85                  90                  95      


Glu Asn Asp Thr His Cys Ile Asp Phe His Tyr Tyr Phe Ser Ser Arg 
            100                 105                 110         


Asp Arg Ser Ser Pro Gly Ala Leu Asn Val Tyr Val Lys Val Asn Gly 
        115                 120                 125             


Gly Pro Gln Gly Asn Pro Val Trp Asn Val Ser Gly Val Val Thr Glu 
    130                 135                 140                 


Gly Trp Val Lys Ala Glu Leu Ala Ile Ser Thr Phe Trp Pro His Phe 
145                 150                 155                 160 


Tyr Gln Val Ile Phe Glu Ser Val Ser Leu Lys Gly His Pro Gly Tyr 
                165                 170                 175     


Ile Ala Val Asp Glu Val Arg Val Leu Ala His Pro Cys Arg Lys Ala 
            180                 185                 190         


Pro His Phe Leu Arg Leu Gln Asn Val Glu Val Asn Val Gly Gln Asn 
        195                 200                 205             


Ala Thr Phe Gln Cys Ile Ala Gly Gly Lys Trp Ser Gln His Asp Lys 
    210                 215                 220                 


Leu Trp Leu Gln Gln Trp Asn Gly Arg Asp Thr Ala Leu Met Val Thr 
225                 230                 235                 240 


Arg Val Val Asn His Arg Arg Phe Ser Ala Thr Val Ser Val Ala Asp 
                245                 250                 255     


Thr Ala Gln Arg Ser Val Ser Lys Tyr Arg Cys Val Ile Arg Ser Asp 
            260                 265                 270         


Gly Gly Ser Gly Val Ser Asn Tyr Ala Glu Leu Ile Val Lys Glu Pro 
        275                 280                 285             


Pro Thr Pro Ile Ala Pro Pro Glu Leu Leu Ala Val Gly Ala Thr Tyr 
    290                 295                 300                 


Leu Trp Ile Lys Pro Asn Ala Asn Ser Ile Ile Gly Asp Gly Pro Ile 
305                 310                 315                 320 


Ile Leu Lys Glu Val Glu Tyr Arg Thr Thr Thr Gly Thr Trp Ala Glu 
                325                 330                 335     


Thr His Ile Val Asp Ser Pro Asn Tyr Lys Leu Trp His Leu Asp Pro 
            340                 345                 350         


Asp Val Glu Tyr Glu Ile Arg Val Leu Leu Thr Arg Pro Gly Glu Gly 
        355                 360                 365             


Gly Thr Gly Pro Pro Gly Pro Pro Leu Thr Thr Arg Thr Lys Cys Ala 
    370                 375                 380                 


Asp Pro Val His Gly Pro Gln Asn Val Glu Ile Val Asp Ile Arg Ala 
385                 390                 395                 400 


Arg Gln Leu Thr Leu Gln Trp Glu Pro Phe Gly Tyr Ala Val Thr Arg 
                405                 410                 415     


Cys His Ser Tyr Asn Leu Thr Val Gln Tyr Gln Tyr Val Phe Asn Gln 
            420                 425                 430         


Gln Gln Tyr Glu Ala Glu Glu Val Ile Gln Thr Ser Ser His Tyr Thr 
        435                 440                 445             


Leu Arg Gly Leu Arg Pro Phe Met Thr Ile Arg Leu Arg Leu Leu Leu 
    450                 455                 460                 


Ser Asn Pro Glu Gly Arg Met Glu Ser Glu Glu Leu Val Val Gln Thr 
465                 470                 475                 480 


Glu Glu Asp Val Pro Gly Ala Val Pro Leu Glu Ser Ile Gln Gly Gly 
                485                 490                 495     


Pro Phe Glu Glu Lys Ile Tyr Ile Gln Trp Lys Pro Pro Asn Glu Thr 
            500                 505                 510         


Asn Gly Val Ile Thr Leu Tyr Glu Ile Asn Tyr Lys Ala Val Gly Ser 
        515                 520                 525             


Leu Asp Pro Ser Ala Asp Leu Ser Ser Gln Arg Gly Lys Val Phe Lys 
    530                 535                 540                 


Leu Arg Asn Glu Thr His His Leu Phe Val Gly Leu Tyr Pro Gly Thr 
545                 550                 555                 560 


Thr Tyr Ser Phe Thr Ile Lys Ala Ser Thr Ala Lys Gly Phe Gly Pro 
                565                 570                 575     


Pro Val Thr Thr Arg Ile Ala Thr Lys Ile Ser Ala Pro Ser Met Pro 
            580                 585                 590         


Glu Tyr Asp Thr Asp Thr Pro Leu Asn Glu Thr Asp Thr Thr Ile Thr 
        595                 600                 605             


Val Met Leu Lys Pro Ala Gln Ser Arg Gly Ala Pro Val Ser Val Tyr 
    610                 615                 620                 


Gln Leu Val Val Lys Glu Glu Arg Leu Gln Lys Ser Arg Arg Ala Ala 
625                 630                 635                 640 


Asp Ile Ile Glu Cys Phe Ser Val Pro Val Ser Tyr Arg Asn Ala Ser 
                645                 650                 655     


Ser Leu Asp Ser Leu His Tyr Phe Ala Ala Glu Leu Lys Pro Ala Asn 
            660                 665                 670         


Leu Pro Val Thr Gln Pro Phe Thr Val Gly Asp Asn Lys Thr Tyr Asn 
        675                 680                 685             


Gly Tyr Trp Asn Pro Pro Leu Ser Pro Leu Lys Ser Tyr Ser Ile Tyr 
    690                 695                 700                 


Phe Gln Ala Leu Ser Lys Ala Asn Gly Glu Thr Lys Ile Asn Cys Val 
705                 710                 715                 720 


Arg Leu Ala Thr Lys Ala Pro Met Gly Ser Ala Gln Val Thr Pro Gly 
                725                 730                 735     


Thr Pro Leu Cys Leu Leu Thr Thr Gly Ala Ser Thr Gln Asn Ser Asn 
            740                 745                 750         


Thr Val Glu Pro Glu Lys Gln Val Asp Asn Thr Val Lys Met Ala Gly 
        755                 760                 765             


Val Ile Ala Gly Leu Leu Met Phe Ile Ile Ile Leu Leu Gly Val Met 
    770                 775                 780                 


Leu Thr Ile Lys Arg Arg Arg Asn Ala Tyr Ser Tyr Ser Tyr Tyr Leu 
785                 790                 795                 800 


Lys Leu Ala Lys Lys Gln Lys Glu Thr Gln Ser Gly Ala Gln Arg Glu 
                805                 810                 815     


Met Gly Pro Val Ala Ser Ala Asp Lys Pro Thr Thr Lys Leu Ser Ala 
            820                 825                 830         


Ser Arg Asn Asp Glu Gly Phe Ser Ser Ser Ser Gln Asp Val Asn Gly 
        835                 840                 845             


Phe Thr Asp Gly Ser Arg Gly Glu Leu Ser Gln Pro Thr Leu Thr Ile 
    850                 855                 860                 


Gln Thr His Pro Tyr Arg Thr Cys Asp Pro Val Glu Met Ser Tyr Pro 
865                 870                 875                 880 


Arg Asp Gln Phe Gln Pro Ala Ile Arg Val Ala Asp Leu Leu Gln His 
                885                 890                 895     


Ile Thr Gln Met Lys Arg Gly Gln Gly Tyr Gly Phe Lys Glu Glu Tyr 
            900                 905                 910         


Glu Ala Leu Pro Glu Gly Gln Thr Ala Ser Trp Asp Thr Ala Lys Glu 
        915                 920                 925             


Asp Glu Asn Arg Asn Lys Asn Arg Tyr Gly Asn Ile Ile Ser Tyr Asp 
    930                 935                 940                 


His Ser Arg Val Arg Leu Leu Val Leu Asp Gly Asp Pro His Ser Asp 
945                 950                 955                 960 


Tyr Ile Asn Ala Asn Tyr Ile Asp Gly Tyr His Arg Pro Arg His Tyr 
                965                 970                 975     


Ile Ala Thr Gln Gly Pro Met Gln Glu Thr Val Lys Asp Phe Trp Arg 
            980                 985                 990         


Met Ile Trp Gln Glu Asn Ser Ala  Ser Ile Val Met Val  Thr Asn Leu 
        995                 1000                 1005             


Val Glu  Val Gly Arg Val Lys  Cys Val Arg Tyr Trp  Pro Asp Asp 
    1010                 1015                 1020             


Thr Glu  Val Tyr Gly Asp Ile  Lys Val Thr Leu Ile  Glu Thr Glu 
    1025                 1030                 1035             


Pro Leu  Ala Glu Tyr Val Ile  Arg Thr Phe Thr Val  Gln Lys Lys 
    1040                 1045                 1050             


Gly Tyr  His Glu Ile Arg Glu  Leu Arg Leu Phe His  Phe Thr Ser 
    1055                 1060                 1065             


Trp Pro  Asp His Gly Val Pro  Cys Tyr Ala Thr Gly  Leu Leu Gly 
    1070                 1075                 1080             


Phe Val  Arg Gln Val Lys Phe  Leu Asn Pro Pro Glu  Ala Gly Pro 
    1085                 1090                 1095             


Ile Val  Val His Cys Ser Ala  Gly Ala Gly Arg Thr  Gly Cys Phe 
    1100                 1105                 1110             


Ile Ala  Ile Asp Thr Met Leu  Asp Met Ala Glu Asn  Glu Gly Val 
    1115                 1120                 1125             


Val Asp  Ile Phe Asn Cys Val  Arg Glu Leu Arg Ala  Gln Arg Val 
    1130                 1135                 1140             


Asn Leu  Val Gln Thr Glu Glu  Gln Tyr Val Phe Val  His Asp Ala 
    1145                 1150                 1155             


Ile Leu  Glu Ala Cys Leu Cys  Gly Asn Thr Ala Ile  Pro Val Cys 
    1160                 1165                 1170             


Glu Phe  Arg Ser Leu Tyr Tyr  Asn Ile Ser Arg Leu  Asp Pro Gln 
    1175                 1180                 1185             


Thr Asn  Ser Ser Gln Ile Lys  Asp Glu Phe Gln Thr  Leu Asn Ile 
    1190                 1195                 1200             


Val Thr  Pro Arg Val Arg Pro  Glu Asp Cys Ser Ile  Gly Leu Leu 
    1205                 1210                 1215             


Pro Arg  Asn His Asp Lys Asn  Arg Ser Met Asp Val  Leu Pro Leu 
    1220                 1225                 1230             


Asp Arg  Cys Leu Pro Phe Leu  Ile Ser Val Asp Gly  Glu Ser Ser 
    1235                 1240                 1245             


Asn Tyr  Ile Asn Ala Ala Leu  Met Asp Ser His Lys  Gln Pro Ala 
    1250                 1255                 1260             


Ala Phe  Val Val Thr Gln His  Pro Leu Pro Asn Thr  Val Ala Asp 
    1265                 1270                 1275             


Phe Trp  Arg Leu Val Phe Asp  Tyr Asn Cys Ser Ser  Val Val Met 
    1280                 1285                 1290             


Leu Asn  Glu Met Asp Thr Ala  Gln Phe Cys Met Gln  Tyr Trp Pro 
    1295                 1300                 1305             


Glu Lys  Thr Ser Gly Cys Tyr  Gly Pro Ile Gln Val  Glu Phe Val 
    1310                 1315                 1320             


Ser Ala  Asp Ile Asp Glu Asp  Ile Ile His Arg Ile  Phe Arg Ile 
    1325                 1330                 1335             


Cys Asn  Met Ala Arg Pro Gln  Asp Gly Tyr Arg Ile  Val Gln His 
    1340                 1345                 1350             


Leu Gln  Tyr Ile Gly Trp Pro  Ala Tyr Arg Asp Thr  Pro Pro Ser 
    1355                 1360                 1365             


Lys Arg  Ser Leu Leu Lys Val  Val Arg Arg Leu Glu  Lys Trp Gln 
    1370                 1375                 1380             


Glu Gln  Tyr Asp Gly Arg Glu  Gly Arg Thr Val Val  His Cys Leu 
    1385                 1390                 1395             


Asn Gly  Gly Gly Arg Ser Gly  Thr Phe Cys Ala Ile  Cys Ser Val 
    1400                 1405                 1410             


Cys Glu  Met Ile Gln Gln Gln  Asn Ile Ile Asp Val  Phe His Ile 
    1415                 1420                 1425             


Val Lys  Thr Leu Arg Asn Asn  Lys Ser Asn Met Val  Glu Thr Leu 
    1430                 1435                 1440             


Glu Gln  Tyr Lys Phe Val Tyr  Glu Val Ala Leu Glu  Tyr Leu Ser 
    1445                 1450                 1455             


Ser Phe  
    1460 

<210>  544
<211>  2592
<212>  DNA
<213>  Homo sapiens

<400>  544
cgcccaccca tccggggcaa gagccgcgcc gcaggagagg caggctggac cgggggctcc     60

ccgggcccgc gacccccgcc gtgaccccgc agcccccagc tcgcccccaa gatgatgaag    120

aggcagctgc accgcatgcg gcagctggcc cagacgggca gcttgggacg caccccggag    180

accgctgagt tcctgggtga ggacctgctg caggtagaac agcggctgga gccggccaag    240

cgggcagccc acaacatcca caagcggctg caggcctgtc tgcagggcca gagcggggca    300

gacatggaca agcgggtgaa gaagcttccc ctcatggctc tgtccaccac gatggctgag    360

agcttcaagg agctggaccc tgattccagc atggggaagg ccttggagat gagctgtgcc    420

atccagaatc agctggcccg catcctggcc gagtttgaga tgaccctgga gagggacgtc    480

ctgcagccac tcagcaggct gagtgaggag gagctgccag ccatcctcaa acacaagaaa    540

agcctccaga agctcgtgtc cgactggaac acactcaaga gcaggctcag tcaggcaacc    600

aagaattcag gcagcagtca aggcctagga ggcagcccgg gtagtcacag ccatacgacc    660

atggccaaca aggtggagac gctgaaggag gaggaggagg agctgaagag gaaagtggag    720

caatgcaggg acgagtactt ggctgacctg taccactttg ttaccaagga ggactcctat    780

gccaactact tcattcgtct cctggagatt caggccgatt accatcgcag gtcactgagc    840

tcgctggaca cagccctggc tgagctgagg gagaaccacg gccaagcaga ccactcccct    900

tcgatgacag ccacccactt ccccagggtg tatggggtgt cgctggcaac ccacctgcaa    960

gagctgggcc gggagattgc cctgcccatc gaggcctgcg tcatgatgct gctttctgag   1020

ggcatgaagg aagagggtct cttccgtctg gctgctgggg cctcggtgct gaagcgtctc   1080

aagcagacaa tggcctcgga cccccacagc ctggaggagt tctgctccga cccgcacgct   1140

gtggcaggtg ccctcaagtc ctatctgcgg gagctgccag agcctctgat gaccttcgac   1200

ctctatgatg actggatgag ggcagccagc ctgaaggagc caggggcccg gctgcaggcc   1260

ctccaagagg tgtgcagccg cctacccccc gagaacctca gcaacctcag gtacctgatg   1320

aagttcctgg cacggctggc cgaggagcag gaggtgaaca agatgacacc cagcaacatc   1380

gccatagtcc tgggacccaa cttgctgtgg ccacctgaga aagaagggga ccaggcccag   1440

ctggatgcag cctccgtgtc ttccatccag gtggtgggcg tcgtcgaggc gctgatccag   1500

agcgcagaca ccctcttccc tggagacatc aacttcaacg tgtcaggcct cttctcagct   1560

gttaccctcc aggacacagt cagtgacagg ctggcctctg aggaacttcc gtccactgcc   1620

gtgcccaccc cagccaccac cccggctccg gctccggctc cagctccagc tccggcccca   1680

gccttggctt cagcagctac caaggaaagg acagagtctg aggtgcctcc cagaccagcc   1740

tcccccaagg tcaccaggag tcccccggag acagctgccc cagtggagga catggctcgg   1800

aggaccaagc gcccggcgcc agcccggccc accatgccgc ccccccaggt ctccggctcc   1860

cgctcctccc ctccagcccc gcccttgccc cctggctctg gcagccctgg gaccccccaa   1920

gccctgcccc gacgtctggt tggcagcagc ctccgagccc ccacagtgcc acccccgtta   1980

ccccccacac cccctcagcc tgcccggcgc caaagccggc gttcaccagc ctcccccagc   2040

ccggcctccc caggtccagc ctcccccagc ccagtctctt tgagtaaccc tgcacaggtg   2100

gacctggggg ctgccacagc agagggagga gcccctgagg ctatcagtgg ggtccccact   2160

cccccagcta tcccccctca gccccgcccc aggagccttg cctcagagac caactgagtg   2220

gctggtttct ccctaagcag ccctcagcac cccctccctc cccacctggc cctcccagga   2280

cagctctcgc cccccacaaa ggggcatggg cctccagcct ttgcccacaa gtgcctcagt   2340

gcccactggg tcggccccca tggccaggag ggctcaggac aatcctctat ttcctgacct   2400

tttcctcgtc caccctgggc ttggggaccc ccccaccgga ctctccactc tccggcaggt   2460

cctaggggag ccaccggaag gaaggagagg tttgcctgct cctacgggac tgattcttct   2520

cttgccgaca tgttttttgt aaggctggta aataaattat tttggacaaa actggaaaaa   2580

aaaaaaaaaa aa                                                       2592


<210>  545
<211>  701
<212>  PRT
<213>  Homo sapiens

<400>  545


Met Met Lys Arg Gln Leu His Arg Met Arg Gln Leu Ala Gln Thr Gly 
1               5                   10                  15      


Ser Leu Gly Arg Thr Pro Glu Thr Ala Glu Phe Leu Gly Glu Asp Leu 
            20                  25                  30          


Leu Gln Val Glu Gln Arg Leu Glu Pro Ala Lys Arg Ala Ala His Asn 
        35                  40                  45              


Ile His Lys Arg Leu Gln Ala Cys Leu Gln Gly Gln Ser Gly Ala Asp 
    50                  55                  60                  


Met Asp Lys Arg Val Lys Lys Leu Pro Leu Met Ala Leu Ser Thr Thr 
65                  70                  75                  80  


Met Ala Glu Ser Phe Lys Glu Leu Asp Pro Asp Ser Ser Met Gly Lys 
                85                  90                  95      


Ala Leu Glu Met Ser Cys Ala Ile Gln Asn Gln Leu Ala Arg Ile Leu 
            100                 105                 110         


Ala Glu Phe Glu Met Thr Leu Glu Arg Asp Val Leu Gln Pro Leu Ser 
        115                 120                 125             


Arg Leu Ser Glu Glu Glu Leu Pro Ala Ile Leu Lys His Lys Lys Ser 
    130                 135                 140                 


Leu Gln Lys Leu Val Ser Asp Trp Asn Thr Leu Lys Ser Arg Leu Ser 
145                 150                 155                 160 


Gln Ala Thr Lys Asn Ser Gly Ser Ser Gln Gly Leu Gly Gly Ser Pro 
                165                 170                 175     


Gly Ser His Ser His Thr Thr Met Ala Asn Lys Val Glu Thr Leu Lys 
            180                 185                 190         


Glu Glu Glu Glu Glu Leu Lys Arg Lys Val Glu Gln Cys Arg Asp Glu 
        195                 200                 205             


Tyr Leu Ala Asp Leu Tyr His Phe Val Thr Lys Glu Asp Ser Tyr Ala 
    210                 215                 220                 


Asn Tyr Phe Ile Arg Leu Leu Glu Ile Gln Ala Asp Tyr His Arg Arg 
225                 230                 235                 240 


Ser Leu Ser Ser Leu Asp Thr Ala Leu Ala Glu Leu Arg Glu Asn His 
                245                 250                 255     


Gly Gln Ala Asp His Ser Pro Ser Met Thr Ala Thr His Phe Pro Arg 
            260                 265                 270         


Val Tyr Gly Val Ser Leu Ala Thr His Leu Gln Glu Leu Gly Arg Glu 
        275                 280                 285             


Ile Ala Leu Pro Ile Glu Ala Cys Val Met Met Leu Leu Ser Glu Gly 
    290                 295                 300                 


Met Lys Glu Glu Gly Leu Phe Arg Leu Ala Ala Gly Ala Ser Val Leu 
305                 310                 315                 320 


Lys Arg Leu Lys Gln Thr Met Ala Ser Asp Pro His Ser Leu Glu Glu 
                325                 330                 335     


Phe Cys Ser Asp Pro His Ala Val Ala Gly Ala Leu Lys Ser Tyr Leu 
            340                 345                 350         


Arg Glu Leu Pro Glu Pro Leu Met Thr Phe Asp Leu Tyr Asp Asp Trp 
        355                 360                 365             


Met Arg Ala Ala Ser Leu Lys Glu Pro Gly Ala Arg Leu Gln Ala Leu 
    370                 375                 380                 


Gln Glu Val Cys Ser Arg Leu Pro Pro Glu Asn Leu Ser Asn Leu Arg 
385                 390                 395                 400 


Tyr Leu Met Lys Phe Leu Ala Arg Leu Ala Glu Glu Gln Glu Val Asn 
                405                 410                 415     


Lys Met Thr Pro Ser Asn Ile Ala Ile Val Leu Gly Pro Asn Leu Leu 
            420                 425                 430         


Trp Pro Pro Glu Lys Glu Gly Asp Gln Ala Gln Leu Asp Ala Ala Ser 
        435                 440                 445             


Val Ser Ser Ile Gln Val Val Gly Val Val Glu Ala Leu Ile Gln Ser 
    450                 455                 460                 


Ala Asp Thr Leu Phe Pro Gly Asp Ile Asn Phe Asn Val Ser Gly Leu 
465                 470                 475                 480 


Phe Ser Ala Val Thr Leu Gln Asp Thr Val Ser Asp Arg Leu Ala Ser 
                485                 490                 495     


Glu Glu Leu Pro Ser Thr Ala Val Pro Thr Pro Ala Thr Thr Pro Ala 
            500                 505                 510         


Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Leu Ala Ser Ala 
        515                 520                 525             


Ala Thr Lys Glu Arg Thr Glu Ser Glu Val Pro Pro Arg Pro Ala Ser 
    530                 535                 540                 


Pro Lys Val Thr Arg Ser Pro Pro Glu Thr Ala Ala Pro Val Glu Asp 
545                 550                 555                 560 


Met Ala Arg Arg Thr Lys Arg Pro Ala Pro Ala Arg Pro Thr Met Pro 
                565                 570                 575     


Pro Pro Gln Val Ser Gly Ser Arg Ser Ser Pro Pro Ala Pro Pro Leu 
            580                 585                 590         


Pro Pro Gly Ser Gly Ser Pro Gly Thr Pro Gln Ala Leu Pro Arg Arg 
        595                 600                 605             


Leu Val Gly Ser Ser Leu Arg Ala Pro Thr Val Pro Pro Pro Leu Pro 
    610                 615                 620                 


Pro Thr Pro Pro Gln Pro Ala Arg Arg Gln Ser Arg Arg Ser Pro Ala 
625                 630                 635                 640 


Ser Pro Ser Pro Ala Ser Pro Gly Pro Ala Ser Pro Ser Pro Val Ser 
                645                 650                 655     


Leu Ser Asn Pro Ala Gln Val Asp Leu Gly Ala Ala Thr Ala Glu Gly 
            660                 665                 670         


Gly Ala Pro Glu Ala Ile Ser Gly Val Pro Thr Pro Pro Ala Ile Pro 
        675                 680                 685             


Pro Gln Pro Arg Pro Arg Ser Leu Ala Ser Glu Thr Asn 
    690                 695                 700     

<210>  546
<211>  2072
<212>  DNA
<213>  Homo sapiens

<400>  546
cgccgtgccc gcggagagag cgcggcgcgg gaggccggcg gccggccggc tgcatggcgc     60

gctgcgagag gctgcgcgga gcggccctgc gcgacgtgct gggccgggcg cagggggtcc    120

tgttcgactg tgacggggtg ctgtggaacg gcgagcgcgc cgtgccgggc gccccggagc    180

tgctggagcg gctggcgcgg gccggcaagg cggctctgtt tgtgagcaac aacagccggc    240

gcgcgcggcc cgagctggcc ctgcgcttcg cgcgcctcgg cttcgggggg ctgcgcgccg    300

agcagctctt cagctccgcg ctgtgcgccg cgcgcctgct gcgccagcgc ctgcccgggc    360

ctccggacgc gccgggcgcc gtgttcgtgc tgggcggcga ggggctgcgc gccgagctgc    420

gcgccgcggg gctgcgcctg gccggggacc cgagcgcggg ggacggcgcg gccccgcgcg    480

tgcgcgccgt gcttgtgggc tacgacgagc acttctcctt cgccaagctg agggaggcgt    540

gcgcgcacct gcgcgacccc gagtgcctac tcgtggccac cgaccgtgac ccatggcacc    600

cgctgagcga cggcagccgg acccctggca ccgggagcct ggccgctgca gtggagacag    660

cctcgggacg ccaggccctg gtggtgggca agcccagccc ctacatgttc gagtgcatca    720

cggagaactt cagcatcgac cccgcacgca cgcttatggt gggtgaccgc ctggagaccg    780

acatcctctt tggccaccgc tgcggcatga ccactgtgct cacgctcaca ggagtctccc    840

gcctagaaga ggcccaggcc tacctagcgg ccggccagca cgacctcgtg ccccattact    900

atgtggagag catcgcagac ttgacagagg ggttggagga ctgagcccac tgcacctgca    960

gccacaggcc cacccctccc cactccctga tcccgtaggt ggaggcgatg ggtcacgagc   1020

catgttaagc acaaccggct ccttggtcca gttctgcacc ggggtggggc tgggacccgg   1080

ggaaggtttg agggcccttg caaccccctc ccagcagtgg ctgggcactc tttgctgccc   1140

cagaagctgg tcccctatgg attcatcttg gcctgaccca gccaggtggc cttatttctt   1200

ccctgtcacc tcccctcctt gaaatctggg ccctggtgcc tgctgaagat tccctctatc   1260

cctgagtact tagtcttctc ccccttccct ggggcttcta gagctctctc tgcccctcag   1320

gtcctggccc ttgggtcctt gtcaaccaga ggtctaggga accacaaccc ttattgtcct   1380

gggtggacca atccaaaggc taagtgatag tgactcatca atgttgggtc ctgtggggta   1440

ccagtttagg ttcctaagta atagtgaccc tttcacgtcc tggagcccga gtggaccaat   1500

cggaagccta agtgacgatg accctcgcat gtcctaggtc cctgggtgga cccatcagga   1560

ccccaagtga tagtgaccca gtggtctttt agatcctcag tagaacagtc cagaagcctg   1620

agagacagtg gccccttgat aatctgggtc tcacgggacc agctaggggt ccaggtttca   1680

gtcagtaaat aagagtggtc cacgtcctaa agacacctct cctttacaaa gacttgtgat   1740

gctctggggc ttctgtggcc aagccccacc ctttcctggt catggtaccc gtacagcgtt   1800

gatggccaca gctcgaaggg gggctttcgt gtccccctgt gcggtcagtg ttttcagtac   1860

cacctctctc ccgtgcccac ttggctattt acttatttat ttattgtgtg ccagtgatgg   1920

tgggtggggg ctgggccttc cccgccacct ccacccctgt tgtgacctgt ccttccgtac   1980

ttaataaagt gcgcgtggga gtgttaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   2040

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa                                 2072


<210>  547
<211>  296
<212>  PRT
<213>  Homo sapiens

<400>  547


Met Ala Arg Cys Glu Arg Leu Arg Gly Ala Ala Leu Arg Asp Val Leu 
1               5                   10                  15      


Gly Arg Ala Gln Gly Val Leu Phe Asp Cys Asp Gly Val Leu Trp Asn 
            20                  25                  30          


Gly Glu Arg Ala Val Pro Gly Ala Pro Glu Leu Leu Glu Arg Leu Ala 
        35                  40                  45              


Arg Ala Gly Lys Ala Ala Leu Phe Val Ser Asn Asn Ser Arg Arg Ala 
    50                  55                  60                  


Arg Pro Glu Leu Ala Leu Arg Phe Ala Arg Leu Gly Phe Gly Gly Leu 
65                  70                  75                  80  


Arg Ala Glu Gln Leu Phe Ser Ser Ala Leu Cys Ala Ala Arg Leu Leu 
                85                  90                  95      


Arg Gln Arg Leu Pro Gly Pro Pro Asp Ala Pro Gly Ala Val Phe Val 
            100                 105                 110         


Leu Gly Gly Glu Gly Leu Arg Ala Glu Leu Arg Ala Ala Gly Leu Arg 
        115                 120                 125             


Leu Ala Gly Asp Pro Ser Ala Gly Asp Gly Ala Ala Pro Arg Val Arg 
    130                 135                 140                 


Ala Val Leu Val Gly Tyr Asp Glu His Phe Ser Phe Ala Lys Leu Arg 
145                 150                 155                 160 


Glu Ala Cys Ala His Leu Arg Asp Pro Glu Cys Leu Leu Val Ala Thr 
                165                 170                 175     


Asp Arg Asp Pro Trp His Pro Leu Ser Asp Gly Ser Arg Thr Pro Gly 
            180                 185                 190         


Thr Gly Ser Leu Ala Ala Ala Val Glu Thr Ala Ser Gly Arg Gln Ala 
        195                 200                 205             


Leu Val Val Gly Lys Pro Ser Pro Tyr Met Phe Glu Cys Ile Thr Glu 
    210                 215                 220                 


Asn Phe Ser Ile Asp Pro Ala Arg Thr Leu Met Val Gly Asp Arg Leu 
225                 230                 235                 240 


Glu Thr Asp Ile Leu Phe Gly His Arg Cys Gly Met Thr Thr Val Leu 
                245                 250                 255     


Thr Leu Thr Gly Val Ser Arg Leu Glu Glu Ala Gln Ala Tyr Leu Ala 
            260                 265                 270         


Ala Gly Gln His Asp Leu Val Pro His Tyr Tyr Val Glu Ser Ile Ala 
        275                 280                 285             


Asp Leu Thr Glu Gly Leu Glu Asp 
    290                 295     

<210>  548
<211>  586
<212>  DNA
<213>  Homo sapiens

<400>  548
agttaaaagg gtgggagcgt ccgggggccc atctctctcg ggtggagtct tctgacagct     60

ggtgcgcctg cccgggaaca tcctcctgga ctcaatcatg gcttgtggtc tggtcgccag    120

caacctgaat ctcaaacctg gagagtgcct tcgagtgcga ggcgaggtgg ctcctgacgc    180

taagagcttc gtgctgaacc tgggcaaaga cagcaacaac ctgtgcctgc acttcaaccc    240

tcgcttcaac gcccacggcg acgccaacac catcgtgtgc aacagcaagg acggcggggc    300

ctgggggacc gagcagcggg aggctgtctt tcccttccag cctggaagtg ttgcagaggt    360

gtgcatcacc ttcgaccagg ccaacctgac cgtcaagctg ccagatggat acgaattcaa    420

gttccccaac cgcctcaacc tggaggccat caactacatg gcagctgacg gtgacttcaa    480

gatcaaatgt gtggcctttg actgaaatca gccagcccat ggcccccaat aaaggcagct    540

gcctctgctc cctctgaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa                   586


<210>  549
<211>  135
<212>  PRT
<213>  Homo sapiens

<400>  549


Met Ala Cys Gly Leu Val Ala Ser Asn Leu Asn Leu Lys Pro Gly Glu 
1               5                   10                  15      


Cys Leu Arg Val Arg Gly Glu Val Ala Pro Asp Ala Lys Ser Phe Val 
            20                  25                  30          


Leu Asn Leu Gly Lys Asp Ser Asn Asn Leu Cys Leu His Phe Asn Pro 
        35                  40                  45              


Arg Phe Asn Ala His Gly Asp Ala Asn Thr Ile Val Cys Asn Ser Lys 
    50                  55                  60                  


Asp Gly Gly Ala Trp Gly Thr Glu Gln Arg Glu Ala Val Phe Pro Phe 
65                  70                  75                  80  


Gln Pro Gly Ser Val Ala Glu Val Cys Ile Thr Phe Asp Gln Ala Asn 
                85                  90                  95      


Leu Thr Val Lys Leu Pro Asp Gly Tyr Glu Phe Lys Phe Pro Asn Arg 
            100                 105                 110         


Leu Asn Leu Glu Ala Ile Asn Tyr Met Ala Ala Asp Gly Asp Phe Lys 
        115                 120                 125             


Ile Lys Cys Val Ala Phe Asp 
    130                 135 

<210>  550
<211>  2840
<212>  DNA
<213>  Homo sapiens

<400>  550
gagtacgcta cacccggaag tgtcttcagg gagaggaagc cggcggcctc actgctatgg     60

gccgcaacaa gaagaagaag cgagatggtg acgaccggcg gccgaggctc gttcttagct    120

tcgacgagga gaagaggcgg gagtacctga caggcttcca caagcggaag gtcgagcgaa    180

agaaggcagc cattgaggag attaagcagc ggctgaaaga ggagcagagg aagcttcggg    240

aggagcgcca ccaggaatac ttgaagatgc tggcagagag agaagaggct ctggaggagg    300

cagatgagct ggaccggttg gtgacagcaa agacggagtc ggtgcagtat gaccacccca    360

accacacagt caccgtgacc accatcagtg acctggacct ctcgggggcc cggctgctcg    420

ggctgacccc acctgaggga ggggctggag acaggtctga ggaggaggcg tcatccacgg    480

agaaaccaac caaagccttg cccaggaagt ccagagaccc cctgctctct cagcggatct    540

cctccctcac agcatcacta catgcacaca gccgcaaaaa ggtcaagagg aaacatcccc    600

gacgggccca ggactccaaa aagcccccaa gggcccctcg taccagcaag gcccagcgcc    660

gccgtctcac aggcaaagca cggcacagcg gggagtgaga ccgagaacga agcggtgccc    720

cagtctaggc tgcggggacc tgtccttgct cagcttggct gtccctgtag cccagcctgc    780

acctaggtaa tgactgcaca gctcaaggtt gggaagccag gacctctctg gcctggggcc    840

agctgccttt gcctggggtc agctgccttt gcctggggtt tgaattcccg aaggagcagg    900

cagctgagag caggcctccc ccaggaagag ccttcagagc cacgtggggg catcttccca    960

aatgtgcacc ccacctggca ctcatcagat ttgtgcgctt gtgatttgtt tgtccttgat   1020

accacgcaca agggcaggtt tttggggtgg tggaaatggc cagggcccat gggtctgtct   1080

ccagcagtta gccctgtggc tgcaataaag tacagttctc cctgtgttaa gatcctaacc   1140

agggttaagg atcagtgtgt ccgttgctag aatccagagc ccacctgctg ctctgaaaag   1200

caggctcctg aggccagtgg gggagcagtg ccccccatgc ccttcaccga ggagcctctg   1260

tgcctgtccc ttgtcctcgg ccccaggagt ctcctcaact gacactgaag tggtggaagc   1320

agttgagtgc caggtcatcc cccatcacca cactggggca gcgtccccag gcttccagca   1380

gctcccaggt gggtcccaac gtggaaggat taattaattc tttctaaagc agttgcagcc   1440

gggcttggtg gctcacgcct gtaatcccag cactttggga ggcccaggcg ggcagatcac   1500

ttaaggtcgg gagctcgaga ccagcctggc caacatggtg aaaccctgtc tctactaaaa   1560

atgcaaaaat tagccaggtg tggtggcaca cgcgtgtaat cccagctact tgggaggctg   1620

aggtggaaga atcacttgaa ccctggaggc ggaggctgca gtgagccgag atcacgccat   1680

tgcactccag cctgggcaac gttgtgacct tgtctcaaaa aaaaactaaa aaataaagca   1740

gttgcatctt gactcgtaca aaagtagccc ccaccagagt agaccctgcg ggtgccagct   1800

agaactccac aaggggccat gtcttcacac tccttccaga tggatgagtt gatggaaacc   1860

ctgtcccttc cttgtcccag cttgtcagtc ctgggcagga gagaatttca ggttgtgcct   1920

tggttagagg agctgtgttg ggtcctaaac actaggacca caaaggggag tgaactgtgt   1980

tcccagggct tgctgacgcc cgtggactat ggagtcagga tgacaggaca gtgcggtgag   2040

gggcatctgc gacaggactg cgggctctac ccgccctgat gtgggagctc ctggagtggg   2100

ggtgagcagt gagccagggt ctgcagggct gtcctctctc cacagccaac agccaggcct   2160

tacagtgggg caggcttagt gactgtgcct cagttatgct gtacctggga gtgggcaggc   2220

cctctcccat gtcaccatca aaacccactg atgaaggctg gtgggagtct gagggctgca   2280

cccgggtatg gtgagttccc ctcagggatt gtgctgagcg ccttggcctg gcttcttggc   2340

tccgcccacc tgctctccct gccaccaagt tgtcttcccc gggtggcatg tgccacttgg   2400

ctgcctcgtg cctgggcaca gtggtgccta ttatgggccc tccaggtggc tctggtgctc   2460

agcctgctgt gagcaggaac agctgagtcc caggggttct tgcacacagc agggctcggg   2520

tttgaatcca ggctctgctg cttggtcgct gcatgagctt ctgctgtgct gacctctctg   2580

gtttgtctcg tcatgtgtaa ggtgacacca gatacctacc tcttagggct gccccgagac   2640

taaaataaga ccatgtgcat gaaccactta ccaaagtgcc tgttgctctc caggtgtgcc   2700

taccgcatgt tgccgctgct gtttctgctg ggacgtctga ctccagttcc ttctcccctc   2760

tccagtgaca aggtcattta caacttacat ttacaattta tagtgtttac cagtattaaa   2820

ttctcagcca ctcctttcca                                               2840


<210>  551
<211>  213
<212>  PRT
<213>  Homo sapiens

<400>  551


Met Gly Arg Asn Lys Lys Lys Lys Arg Asp Gly Asp Asp Arg Arg Pro 
1               5                   10                  15      


Arg Leu Val Leu Ser Phe Asp Glu Glu Lys Arg Arg Glu Tyr Leu Thr 
            20                  25                  30          


Gly Phe His Lys Arg Lys Val Glu Arg Lys Lys Ala Ala Ile Glu Glu 
        35                  40                  45              


Ile Lys Gln Arg Leu Lys Glu Glu Gln Arg Lys Leu Arg Glu Glu Arg 
    50                  55                  60                  


His Gln Glu Tyr Leu Lys Met Leu Ala Glu Arg Glu Glu Ala Leu Glu 
65                  70                  75                  80  


Glu Ala Asp Glu Leu Asp Arg Leu Val Thr Ala Lys Thr Glu Ser Val 
                85                  90                  95      


Gln Tyr Asp His Pro Asn His Thr Val Thr Val Thr Thr Ile Ser Asp 
            100                 105                 110         


Leu Asp Leu Ser Gly Ala Arg Leu Leu Gly Leu Thr Pro Pro Glu Gly 
        115                 120                 125             


Gly Ala Gly Asp Arg Ser Glu Glu Glu Ala Ser Ser Thr Glu Lys Pro 
    130                 135                 140                 


Thr Lys Ala Leu Pro Arg Lys Ser Arg Asp Pro Leu Leu Ser Gln Arg 
145                 150                 155                 160 


Ile Ser Ser Leu Thr Ala Ser Leu His Ala His Ser Arg Lys Lys Val 
                165                 170                 175     


Lys Arg Lys His Pro Arg Arg Ala Gln Asp Ser Lys Lys Pro Pro Arg 
            180                 185                 190         


Ala Pro Arg Thr Ser Lys Ala Gln Arg Arg Arg Leu Thr Gly Lys Ala 
        195                 200                 205             


Arg His Ser Gly Glu 
    210             

<210>  552
<211>  10024
<212>  DNA
<213>  Homo sapiens

<400>  552
cccaggggag gaggtgaaat tcctcagctc tccaccaaga ttggccacaa aagcctgatc     60

ccctggaaca cagcaggcct cacatagacg gtcagccatt ggatcatagg aactgccctg    120

gcctgactca cccaatatgg aggaggtgcc tggggatgcc ctgtgtgaac actttgaggc    180

caacatactt acccagaacc gctgtcaaaa ctgcttccac cctgaggagg cccatggagc    240

aagataccag gagctcagga gcccttcagg tgctgaggtg ccctactgcg acctgcctcg    300

atgtccacct gcccctgagg acccactcag cgcctcaacc tccggctgcc agtctgtggt    360

ggacccaggc ctcaggccag ggcccaagag gggcccatcc ccctcagcag ggctcccaga    420

agagggtccc acagctgccc ccaggagcag gagccgggag cttgaggcag taccctatct    480

ggagggcctg accacttcct tgtgtggcag ctgcaacgag gaccccggct ctgaccccac    540

ctccagccct gactccgcca cccctgatga taccagcaac tcgtcctctg tggactggga    600

cactgttgag aggcaggagg aggaggcccc cagctgggac gagctcgcag tgatgatccc    660

gaggaggcct cgggaggggc cgagagctga cagctcccaa agggctccgt ctctcctcac    720

caggtcccct gtgggaggag atgctgcagg ccagaaaaag gaggacaccg gcggtggggg    780

ccggagcgca ggacagcact gggcaaggct ccggggagaa agcgggttgt ccctggagcg    840

gcaccggtca acactgaccc aggcttcctc catgacacca cacagtggac ctcgaagcac    900

cacgtctcag gcttctcctg cccaaaggga cactgctcag gctgcctcta cacgtgaaat    960

ccccagagcc tcctctcccc atcgaatcac ccaaagggac acctccaggg cctcatccac   1020

ccaacaggaa atctccaggg cctcatccac ccaacaggaa acctccaggg cctcatccac   1080

ccaagaggac acccctaggg cctcatccac ccaagaggac acccccaggg cctcatctac   1140

acagtggaac acccccagag cttcctctcc ctcacgaagc acccaactgg ataaccccag   1200

aacctcttct acccagcagg acaaccccca aacttctttt cctacttgta ctccccagcg   1260

ggaaaacccc aggacaccct gtgtccagca ggacgatccc agagcctcct ctcccaacag   1320

aaccactcaa cgagagaatt ccagaacatc ctgtgcccag cgggacaatc ccaaagcctc   1380

cagaacctcc tctcccaata gagccacacg agacaacccc agaacatcct gcgcccagcg   1440

ggacaatccc agagcctcct ctcccagtag agctacacga gacaacccca caacatcctg   1500

tgcccagcgg gacaatccca gagcctccag aacctcctct cccaatagag ccacacgaga   1560

caaccccaga acatcctgtg cccagcggga caatcccaga gcctcctctc ccagtagagc   1620

tacacgagac aaccccacaa catcctgtgc ccagcgggac aatcccagag cctccagaac   1680

ctcctctccc aatagagcca cacgagacaa ccccagaaca tcctgcgccc agcgggacaa   1740

tcccagagcc tcctctccca atagagctgc acgagacaac cccacaacat cctgtgccca   1800

gcgggacaat cccagagcct ccagaacctc ctctcccaat agagccacac gagacaaccc   1860

cagaacatcc tgtgcccagc gggacaatcc cagagcctcc tctcccaata gagctacacg   1920

agacaacccc acaacatcct gtgcccagcg ggacaatccc agagcctcca gaacctcctc   1980

tcccaataga gccacacgag ataaccccag aacatcctgt gcccagcggg acaatcccag   2040

agcctcctct cccaacagaa ccacccaaca agacagcccc agaacatcct gtgcccgacg   2100

ggacgatccc agagcctcct ctcctaacag aaccatccaa caagagaacc ccagaacatc   2160

ctgtgcccta cgggacaatc ccagagcctc ctctcccagc agaaccatcc aacaagagaa   2220

ccccagaaca tcctgtgccc aacgggacga tcccagagcc tcctctccta acagaaccac   2280

ccaacaagag aaccccagaa catcctgtgc ccgacgggac aatcccagag cctcctctcg   2340

caacagaacc atccagcgag acaaccccag aacatcctgt gcccagcggg acaatcccag   2400

agcctcctct cctaacagaa ccatccaaca agagaacctc agaacatcct gtacccgaca   2460

ggacaatccc aggacctcct ctcccaatag agccacacga gacaacccca gaacatcctg   2520

tgcccagcgg gacaatctca gagcctcctc tcccatcaga gccacccaac aggacaaccc   2580

cagaacttgt attcaacaga acatccccag atcatcttct acccaacaag acaaccctaa   2640

aacctcttgt accaaacgag ataacctcag acccacttgt acacagcggg accgcacaca   2700

gtccttttcc tttcaacgag acaaccctgg aacctcctca tctcaatgct gcacccaaaa   2760

ggagaatctg agaccatcat ctccccaccg ctccactcaa tggaacaatc ccaggaattc   2820

atctccccat cgtactaaca aagacatccc ctgggcctcg tttcccctcc ggccaactca   2880

gagtgatggt ccccgaacct cttccccatc tcgctccaag caaagcgagg ttccctgggc   2940

atccatcgcc ctccggccaa cccaaggtga caggcctcag acatcctctc ccagcaggcc   3000

agcccagcat gacccacccc agtcctcctt tggccccacc cagtacaact tgccatcccg   3060

ggccacctct tcctcccata acccaggcca ccagagcacc tcccgaactt cctcacctgt   3120

gtaccccgct gcctatgggg ctcccctgac ctctcctgag ccctcccagc ctccatgtgc   3180

tgtgtgcatt gggcaccggg atgcccctcg agcctcttcg ccccctcgct atttgcagca   3240

cgaccccttc cccttcttcc cagagccccg cgcccctgag agtgaaccgc cccaccacga   3300

gcctccctat ataccacctg ctgtgtgcat tggacaccga gatgcccccc gggcgtcctc   3360

gcccccccgc cacacccaat ttgacccctt ccccttcctc ccagacacat cagatgccga   3420

gcatcagtgt cagtcccccc aacacgagcc ccttcagctc cctgcacctg tgtgtattgg   3480

gtaccgagat gcaccccggg cctcctcccc accacgccag gccccagagc cttccctctt   3540

attccaggac ctccccaggg ccagcacaga gagccttgtc ccttccatgg actctctgca   3600

cgagtgcccc cacatcccca cccctgtgtg cattgggcac cgggatgcac cctccttctc   3660

atccccacca cgccaggctc ctgagccatc cctcttcttc caggatcccc ctggaactag   3720

tatggagagc ctggccccct ccactgactc tctgcatggc tccccagtgc tgatccccca   3780

agtgtgcatc gggcaccggg atgcaccccg agcctcctcc ccaccccgcc acccacccag   3840

tgacctagcg ttcctggcac cctcaccttc accgggcagc tctgggggct cccggggctc   3900

agcgcctccc ggggagacca ggcacaactt ggagcgggag gagtacactg tgctggccga   3960

cctgccccca cccaggaggc tggcccagag acagccaggg ccccaggcgc agtgcagcag   4020

cgggggccgc acccacagcc ctggccgtgc agaggtggag cgcctcttcg ggcaagagcg   4080

caggaagtcc gaggcagcgg gggccttcca ggcccaggac gagggacggt cacagcagcc   4140

cagccaaggc cagagccaac ttctccgaag acagtccagc cctgccccca gcaggcaggt   4200

gaccatgctc cctgccaaac aggcagaact gacccggcgg agccaagcag agccccctca   4260

tccttggagt cctgagaaga gacctgaggg agatcggcag ctccaggggt ccccgctgcc   4320

ccccaggaca tcagccagga cccctgagag ggagctgcgg acacagagac ctctggagag   4380

tggccaagca ggcccaagac agcctctggg ggtgtggcag agtcaggagg aaccgccagg   4440

gtcccagggc cctcatagac acctagaaag gagctggagc agccaggagg gaggcctggg   4500

ccctgggggc tggtggggat gtggagagcc cagcctgggg gcagccaaag ccccggaggg   4560

agcatggggg ggcacttcca gggagtacaa ggagagctgg gggcagccag aggcctggga   4620

ggagaagccc actcatgagc tccccagaga actaggaaag agaagcccac tcacgagccc   4680

ccctgagaac tggggaggcc ccgcagagtc ctcacaatcc tggcactctg ggacacccac   4740

tgctgtgggc tggggggcag agggagcgtg tccatacccg cgtggctctg agaggcgacc   4800

cgagcttgac tggagggatc tgcttggcct tctccgggca ccaggagagg gggtctgggc   4860

ccgtgtcccc agcctggact gggagggcct cttggagctc ctgcaggcca ggctgccccg   4920

caaggaccca gctggacaca gggatgacct ggccagggct ttagggccag agctgggtcc   4980

cccaggcaca aacgatgtcc ctgagcagga gtcacacagc cagccagaag gctgggccga   5040

ggccacccca gtcaatggac acagccccgc actgcagtcc cagagcccgg tccagctgcc   5100

cagccctgcc tgcacctcca cccagtggcc aaagatcaaa gtgacaagag gaccagcgac   5160

cgcaactctg gcaggcctgg agcagacggg ccccctgggg agcaggagca ctgcgaaggg   5220

ccccagcttg ccagagctgc agttccaacc agaggagcct gaggagtcag aaccaagcag   5280

aggccaagac cccctgactg accagaagca ggcagactcg gcagacaaga ggccagcaga   5340

gggcaaggct gggagcccgc tcaagggccg actggtgacc tcatggcgga tgcccgggga   5400

ccggcccacg ctgttcaatc cgttcctgct gtctctgggg gtcctcaggt ggcgaaggcc   5460

cgatctgctc aacttcaaga agggatggat gtcgatcttg gacgagcctg gagagcctcc   5520

ctccccctcg ctcaccacca cctctacttc gcagtggaag aaacattggt ttgtgctgac   5580

agattcaagt ctcaaatatt acagagactc cactgctgag gaggcagatg agctggatgg   5640

tgagatcgac ctgcgttcct gcacggatgt cactgagtac gcggtgcagc gcaactatgg   5700

cttccagatc cacaccaagg atgctgtcta taccttgtcg gccatgacct caggcatccg   5760

gcggaactgg atcgaggctc tgagaaagac cgtacgtcca acttcagccc cagatgtcac   5820

caagctctcg gactctaaca aggagaacgc gctgcacagc tacagcaccc agaagggccc   5880

cctgaaggca ggggagcagc gggcgggctc tgaggtcatc agccggggtg gccctcggaa   5940

ggcggacggg cagcgtcagg ccttggacta cgtggagctc tcgccgctga cccaggcttc   6000

cccgcagcgg gcccgcaccc cagcccgcac tcctgaccgc ctggccaagc aggaggagct   6060

ggagcgggac ctggcccagc gctccgagga gcggcgcaag tggtttgagg ccacagacag   6120

caggacccca gaggtgcctg ctggtgaggg gccgcgccgg ggcctgggtg cccccctgac   6180

tgaggaccag caaaaccggc ttagtgagga gatcgagaag aagtggcagg agctggagaa   6240

gctgcccctg cgggagaata agcgggtgcc cctcactgcc ctgctcaacc aaagccgcgg   6300

agagcgccga gggcccccaa gtgacggcca cgaggcactg gagaaggagg ttcaggctct   6360

tcgggcccag ctggaggcgt ggcgtctcca aggggaggct cctcagagtg cactgagatc   6420

ccaggaggat ggccacatcc ccccgggcta catctcacag gaggcatgtg agcgcagcct   6480

ggcagagatg gagtcctcgc accagcaggt gatggaggag ctgcagcggc accacgagcg   6540

ggagctgcag cgcctgcagc aggagaagga gtggctcctg gctgaggaga cggcagccac   6600

ggcctcagcc attgaagcca tgaagaaggc ctaccaggaa gagctgagcc gagagctgag   6660

caaaacacgg agtctccagc agggcccgga tggcctccgg aagcagcacc agtcagatgt   6720

ggaggcactg aagcgagagc tgcaggtgct atcggagcag tactcgcaga agtgcctgga   6780

gattggggca ctcatgcggc aggctgagga gcgcgagcac acgctgcgcc gctgccagca   6840

ggagggccag gagctgctgc gccacaacca ggagctgcat ggccgcctgt cagaggagat   6900

agaccagctg cgcggcttca ttgcctcgca gggcatgggc aatggctgcg ggcgcagcaa   6960

cgagcggagt tcctgcgagc tagaggtgct gcttcgcgta aaagaaaacg aactccagta   7020

cctaaagaag gaggtgcagt gcctccggga cgagctccag atgatgcaga aggacaagcg   7080

cttcacctcg ggaaagtacc aggacgtcta tgtggagctg agccacatca agacacggtc   7140

tgagcgggag atcgagcagc tgaaggagca cctgcgtctt gccatggccg ccctccagga   7200

gaaggagtcg atgcgcaaca gcctggctga gtagaggtcc cgcccagctg cagaccctcc   7260

aggctggagg accagccgcc ctccttccct cctggatgga agtaaaaagc caagctttct   7320

ccccaccctc tgtgggccac acgtgcactt gcacccacca cacacacaca cacacacaca   7380

cacacacaca cagacacaca gacacatacg cacacacgtg cacacatgta cacacggata   7440

cacacacaca cacacacact gcatatctga gcgcgcccct cgcactgggt ctcaccttgc   7500

accttcttca ggattttata tgtgaagaga tttttatata gatttttttc ctttttttcc   7560

aaaacacttt atactttaaa aaaaaaaaaa aaaagcaatt cctggtggct gtgtgcctcc   7620

aaccctggtc cccctctgtc tccagccacc ctctgcttgg gcttctgagc tggtggccct   7680

ggcccagagg tctggcggag gcccaggcag cagccatggc ggggtgtctc tacaggggag   7740

aggcgggagc ctgccaccct cttcctgccc tacctcctac taacacttcc tgccccattt   7800

ggacccgtac catggggctc aggacagagg gagctagcag ctggcctcca tggccccaca   7860

gcctccttcg aggctgtgct gggtgcagaa ccgccagagc cacccaaaag gtgtttctct   7920

tctgctccct gaacctctta acttaataaa acgttccagc agctctggtg tcctagatgg   7980

ctggcagaac aggaatggag attggggttt cttgaagtgg cttccccact cacaccctac   8040

ccacacccca cccttcctaa agcagcggcc tctaggcttc tgagggtggg gctgaaaatc   8100

caaggtctcc cttagtacag actgtgacgc ccccagtgtg gcttgcaggc tagtggcagc   8160

ggaagcatgt gggaaatagc aagtccagtc ccaccccaac ctactgaacc agcgtctgca   8220

ttttaacagg gtgccccagt gattcacgtg accttcaaag tctgaggagc cctggagtag   8280

ggcccagggc ccaggcctga gagagaggcc tggggctaag actagccctg accatgacct   8340

tgggcaagtc acacccctca ctgagcctca gtttgcttct ccatcaaatg ggtgtttttc   8400

tttcagtccc agtcctctcc tgaggctttt cccagaggtc atgcccagcc ctgggcaggg   8460

gtgagggcag ggttgtggct gccaggcaca ggtccagcgg gctgggagtc ctcaccatgg   8520

ctggctgtgc tgattatggt tgcatggggc tgggaagagg tcccatttct gagccacaga   8580

aacaggccac atccagtagg ggtcctggaa ggctgtgaga acccagagga gaccctgacc   8640

cagcctgcag gtagaagact gcctttggag gcagctttga aagatgactc ttccagatgg   8700

aagaatcagg aagggccttc ccacgtggag gcaccagcag gagcaaacgt ccctggtgtg   8760

ttcaggcaaa gagccacagg agagtgacct cgtggagtgg gaagagattg tttcccattc   8820

ccttgccagg gattggttga ggaatggaca aggcttgcag ttcacgcaag ccagtgaaat   8880

gcgaggggaa gtcttgggag tggggtggag gaggtcatct gggaagggtg tccttggtct   8940

taaaaagagg cacaagaggc cgggcgcggt ggctcttgcc tattatccta gcactttggg   9000

aggccaaggc agggggatca cttgaggtca ggagttcgag accagcctgg ccaacatggt   9060

gaaaccccgt ctctactaaa aatacaaaaa attagccaga cgtggtgcca agcacctgta   9120

atcccagcta ctcaggaggc tgaggcagga gaatcacttg aacccaggag gcagaagttg   9180

cagtgagcca agatcgcgcc actgcactcc agcctgtgtg acaagggcga aactccatct   9240

caaaaaaaaa gggggagggt ggcgcaagga gaggacacct ctctcctggc cctgtcgcca   9300

tcttccctca tcaatagcta aaaatggcaa agaagaaaga gccaggaccc cgtgccatca   9360

aatcctccgg ccttgtgctg ccctgtctcg gcactgcttg ccttaggaga tcaggagtgt   9420

tcctagccac tgggagatgg gatgcctgcc actggcagct ctgccgtcca tcctcaccat   9480

cccaccgtcc ccccaagaca gctctccatc ccatcctctg cctcccttct agcctcaacc   9540

taactcaggg ctcccccgtc tcacacctgg gttgcaggaa catcctcttc accaaccccc   9600

ctcccatccc tcctcagggc tgcctagggc agctacaaaa accaggccag cctctgaaag   9660

gtgctccaca tctcattaaa aaccgtgaaa tcgcactgcc ccactatcag aatagctcag   9720

aggagaaggt ctgccagtac caagtgctgg tggggatacg gagaagagca gctcccaggc   9780

gctgctggtg caaatgtgct ttgttgcacc cacggcagga aactgaccag cttctcatca   9840

agttaaatac gcatctaccc tatggcctag catttccact cttgcttaca catccaggag   9900

aaatgagtcc ttacatgcac aaaaggatga gtaccgtaat actcacatca gcaaataaac   9960

aatacagctg tgtgtcagta gtagaatgaa taaattgtgg tcgattcata aaaaaaaaaa  10020

aaaa                                                               10024


<210>  553
<211>  2365
<212>  PRT
<213>  Homo sapiens

<400>  553


Met Glu Glu Val Pro Gly Asp Ala Leu Cys Glu His Phe Glu Ala Asn 
1               5                   10                  15      


Ile Leu Thr Gln Asn Arg Cys Gln Asn Cys Phe His Pro Glu Glu Ala 
            20                  25                  30          


His Gly Ala Arg Tyr Gln Glu Leu Arg Ser Pro Ser Gly Ala Glu Val 
        35                  40                  45              


Pro Tyr Cys Asp Leu Pro Arg Cys Pro Pro Ala Pro Glu Asp Pro Leu 
    50                  55                  60                  


Ser Ala Ser Thr Ser Gly Cys Gln Ser Val Val Asp Pro Gly Leu Arg 
65                  70                  75                  80  


Pro Gly Pro Lys Arg Gly Pro Ser Pro Ser Ala Gly Leu Pro Glu Glu 
                85                  90                  95      


Gly Pro Thr Ala Ala Pro Arg Ser Arg Ser Arg Glu Leu Glu Ala Val 
            100                 105                 110         


Pro Tyr Leu Glu Gly Leu Thr Thr Ser Leu Cys Gly Ser Cys Asn Glu 
        115                 120                 125             


Asp Pro Gly Ser Asp Pro Thr Ser Ser Pro Asp Ser Ala Thr Pro Asp 
    130                 135                 140                 


Asp Thr Ser Asn Ser Ser Ser Val Asp Trp Asp Thr Val Glu Arg Gln 
145                 150                 155                 160 


Glu Glu Glu Ala Pro Ser Trp Asp Glu Leu Ala Val Met Ile Pro Arg 
                165                 170                 175     


Arg Pro Arg Glu Gly Pro Arg Ala Asp Ser Ser Gln Arg Ala Pro Ser 
            180                 185                 190         


Leu Leu Thr Arg Ser Pro Val Gly Gly Asp Ala Ala Gly Gln Lys Lys 
        195                 200                 205             


Glu Asp Thr Gly Gly Gly Gly Arg Ser Ala Gly Gln His Trp Ala Arg 
    210                 215                 220                 


Leu Arg Gly Glu Ser Gly Leu Ser Leu Glu Arg His Arg Ser Thr Leu 
225                 230                 235                 240 


Thr Gln Ala Ser Ser Met Thr Pro His Ser Gly Pro Arg Ser Thr Thr 
                245                 250                 255     


Ser Gln Ala Ser Pro Ala Gln Arg Asp Thr Ala Gln Ala Ala Ser Thr 
            260                 265                 270         


Arg Glu Ile Pro Arg Ala Ser Ser Pro His Arg Ile Thr Gln Arg Asp 
        275                 280                 285             


Thr Ser Arg Ala Ser Ser Thr Gln Gln Glu Ile Ser Arg Ala Ser Ser 
    290                 295                 300                 


Thr Gln Gln Glu Thr Ser Arg Ala Ser Ser Thr Gln Glu Asp Thr Pro 
305                 310                 315                 320 


Arg Ala Ser Ser Thr Gln Glu Asp Thr Pro Arg Ala Ser Ser Thr Gln 
                325                 330                 335     


Trp Asn Thr Pro Arg Ala Ser Ser Pro Ser Arg Ser Thr Gln Leu Asp 
            340                 345                 350         


Asn Pro Arg Thr Ser Ser Thr Gln Gln Asp Asn Pro Gln Thr Ser Phe 
        355                 360                 365             


Pro Thr Cys Thr Pro Gln Arg Glu Asn Pro Arg Thr Pro Cys Val Gln 
    370                 375                 380                 


Gln Asp Asp Pro Arg Ala Ser Ser Pro Asn Arg Thr Thr Gln Arg Glu 
385                 390                 395                 400 


Asn Ser Arg Thr Ser Cys Ala Gln Arg Asp Asn Pro Lys Ala Ser Arg 
                405                 410                 415     


Thr Ser Ser Pro Asn Arg Ala Thr Arg Asp Asn Pro Arg Thr Ser Cys 
            420                 425                 430         


Ala Gln Arg Asp Asn Pro Arg Ala Ser Ser Pro Ser Arg Ala Thr Arg 
        435                 440                 445             


Asp Asn Pro Thr Thr Ser Cys Ala Gln Arg Asp Asn Pro Arg Ala Ser 
    450                 455                 460                 


Arg Thr Ser Ser Pro Asn Arg Ala Thr Arg Asp Asn Pro Arg Thr Ser 
465                 470                 475                 480 


Cys Ala Gln Arg Asp Asn Pro Arg Ala Ser Ser Pro Ser Arg Ala Thr 
                485                 490                 495     


Arg Asp Asn Pro Thr Thr Ser Cys Ala Gln Arg Asp Asn Pro Arg Ala 
            500                 505                 510         


Ser Arg Thr Ser Ser Pro Asn Arg Ala Thr Arg Asp Asn Pro Arg Thr 
        515                 520                 525             


Ser Cys Ala Gln Arg Asp Asn Pro Arg Ala Ser Ser Pro Asn Arg Ala 
    530                 535                 540                 


Ala Arg Asp Asn Pro Thr Thr Ser Cys Ala Gln Arg Asp Asn Pro Arg 
545                 550                 555                 560 


Ala Ser Arg Thr Ser Ser Pro Asn Arg Ala Thr Arg Asp Asn Pro Arg 
                565                 570                 575     


Thr Ser Cys Ala Gln Arg Asp Asn Pro Arg Ala Ser Ser Pro Asn Arg 
            580                 585                 590         


Ala Thr Arg Asp Asn Pro Thr Thr Ser Cys Ala Gln Arg Asp Asn Pro 
        595                 600                 605             


Arg Ala Ser Arg Thr Ser Ser Pro Asn Arg Ala Thr Arg Asp Asn Pro 
    610                 615                 620                 


Arg Thr Ser Cys Ala Gln Arg Asp Asn Pro Arg Ala Ser Ser Pro Asn 
625                 630                 635                 640 


Arg Thr Thr Gln Gln Asp Ser Pro Arg Thr Ser Cys Ala Arg Arg Asp 
                645                 650                 655     


Asp Pro Arg Ala Ser Ser Pro Asn Arg Thr Ile Gln Gln Glu Asn Pro 
            660                 665                 670         


Arg Thr Ser Cys Ala Leu Arg Asp Asn Pro Arg Ala Ser Ser Pro Ser 
        675                 680                 685             


Arg Thr Ile Gln Gln Glu Asn Pro Arg Thr Ser Cys Ala Gln Arg Asp 
    690                 695                 700                 


Asp Pro Arg Ala Ser Ser Pro Asn Arg Thr Thr Gln Gln Glu Asn Pro 
705                 710                 715                 720 


Arg Thr Ser Cys Ala Arg Arg Asp Asn Pro Arg Ala Ser Ser Arg Asn 
                725                 730                 735     


Arg Thr Ile Gln Arg Asp Asn Pro Arg Thr Ser Cys Ala Gln Arg Asp 
            740                 745                 750         


Asn Pro Arg Ala Ser Ser Pro Asn Arg Thr Ile Gln Gln Glu Asn Leu 
        755                 760                 765             


Arg Thr Ser Cys Thr Arg Gln Asp Asn Pro Arg Thr Ser Ser Pro Asn 
    770                 775                 780                 


Arg Ala Thr Arg Asp Asn Pro Arg Thr Ser Cys Ala Gln Arg Asp Asn 
785                 790                 795                 800 


Leu Arg Ala Ser Ser Pro Ile Arg Ala Thr Gln Gln Asp Asn Pro Arg 
                805                 810                 815     


Thr Cys Ile Gln Gln Asn Ile Pro Arg Ser Ser Ser Thr Gln Gln Asp 
            820                 825                 830         


Asn Pro Lys Thr Ser Cys Thr Lys Arg Asp Asn Leu Arg Pro Thr Cys 
        835                 840                 845             


Thr Gln Arg Asp Arg Thr Gln Ser Phe Ser Phe Gln Arg Asp Asn Pro 
    850                 855                 860                 


Gly Thr Ser Ser Ser Gln Cys Cys Thr Gln Lys Glu Asn Leu Arg Pro 
865                 870                 875                 880 


Ser Ser Pro His Arg Ser Thr Gln Trp Asn Asn Pro Arg Asn Ser Ser 
                885                 890                 895     


Pro His Arg Thr Asn Lys Asp Ile Pro Trp Ala Ser Phe Pro Leu Arg 
            900                 905                 910         


Pro Thr Gln Ser Asp Gly Pro Arg Thr Ser Ser Pro Ser Arg Ser Lys 
        915                 920                 925             


Gln Ser Glu Val Pro Trp Ala Ser Ile Ala Leu Arg Pro Thr Gln Gly 
    930                 935                 940                 


Asp Arg Pro Gln Thr Ser Ser Pro Ser Arg Pro Ala Gln His Asp Pro 
945                 950                 955                 960 


Pro Gln Ser Ser Phe Gly Pro Thr Gln Tyr Asn Leu Pro Ser Arg Ala 
                965                 970                 975     


Thr Ser Ser Ser His Asn Pro Gly His Gln Ser Thr Ser Arg Thr Ser 
            980                 985                 990         


Ser Pro Val Tyr Pro Ala Ala Tyr  Gly Ala Pro Leu Thr  Ser Pro Glu 
        995                 1000                 1005             


Pro Ser  Gln Pro Pro Cys Ala  Val Cys Ile Gly His  Arg Asp Ala 
    1010                 1015                 1020             


Pro Arg  Ala Ser Ser Pro Pro  Arg Tyr Leu Gln His  Asp Pro Phe 
    1025                 1030                 1035             


Pro Phe  Phe Pro Glu Pro Arg  Ala Pro Glu Ser Glu  Pro Pro His 
    1040                 1045                 1050             


His Glu  Pro Pro Tyr Ile Pro  Pro Ala Val Cys Ile  Gly His Arg 
    1055                 1060                 1065             


Asp Ala  Pro Arg Ala Ser Ser  Pro Pro Arg His Thr  Gln Phe Asp 
    1070                 1075                 1080             


Pro Phe  Pro Phe Leu Pro Asp  Thr Ser Asp Ala Glu  His Gln Cys 
    1085                 1090                 1095             


Gln Ser  Pro Gln His Glu Pro  Leu Gln Leu Pro Ala  Pro Val Cys 
    1100                 1105                 1110             


Ile Gly  Tyr Arg Asp Ala Pro  Arg Ala Ser Ser Pro  Pro Arg Gln 
    1115                 1120                 1125             


Ala Pro  Glu Pro Ser Leu Leu  Phe Gln Asp Leu Pro  Arg Ala Ser 
    1130                 1135                 1140             


Thr Glu  Ser Leu Val Pro Ser  Met Asp Ser Leu His  Glu Cys Pro 
    1145                 1150                 1155             


His Ile  Pro Thr Pro Val Cys  Ile Gly His Arg Asp  Ala Pro Ser 
    1160                 1165                 1170             


Phe Ser  Ser Pro Pro Arg Gln  Ala Pro Glu Pro Ser  Leu Phe Phe 
    1175                 1180                 1185             


Gln Asp  Pro Pro Gly Thr Ser  Met Glu Ser Leu Ala  Pro Ser Thr 
    1190                 1195                 1200             


Asp Ser  Leu His Gly Ser Pro  Val Leu Ile Pro Gln  Val Cys Ile 
    1205                 1210                 1215             


Gly His  Arg Asp Ala Pro Arg  Ala Ser Ser Pro Pro  Arg His Pro 
    1220                 1225                 1230             


Pro Ser  Asp Leu Ala Phe Leu  Ala Pro Ser Pro Ser  Pro Gly Ser 
    1235                 1240                 1245             


Ser Gly  Gly Ser Arg Gly Ser  Ala Pro Pro Gly Glu  Thr Arg His 
    1250                 1255                 1260             


Asn Leu  Glu Arg Glu Glu Tyr  Thr Val Leu Ala Asp  Leu Pro Pro 
    1265                 1270                 1275             


Pro Arg  Arg Leu Ala Gln Arg  Gln Pro Gly Pro Gln  Ala Gln Cys 
    1280                 1285                 1290             


Ser Ser  Gly Gly Arg Thr His  Ser Pro Gly Arg Ala  Glu Val Glu 
    1295                 1300                 1305             


Arg Leu  Phe Gly Gln Glu Arg  Arg Lys Ser Glu Ala  Ala Gly Ala 
    1310                 1315                 1320             


Phe Gln  Ala Gln Asp Glu Gly  Arg Ser Gln Gln Pro  Ser Gln Gly 
    1325                 1330                 1335             


Gln Ser  Gln Leu Leu Arg Arg  Gln Ser Ser Pro Ala  Pro Ser Arg 
    1340                 1345                 1350             


Gln Val  Thr Met Leu Pro Ala  Lys Gln Ala Glu Leu  Thr Arg Arg 
    1355                 1360                 1365             


Ser Gln  Ala Glu Pro Pro His  Pro Trp Ser Pro Glu  Lys Arg Pro 
    1370                 1375                 1380             


Glu Gly  Asp Arg Gln Leu Gln  Gly Ser Pro Leu Pro  Pro Arg Thr 
    1385                 1390                 1395             


Ser Ala  Arg Thr Pro Glu Arg  Glu Leu Arg Thr Gln  Arg Pro Leu 
    1400                 1405                 1410             


Glu Ser  Gly Gln Ala Gly Pro  Arg Gln Pro Leu Gly  Val Trp Gln 
    1415                 1420                 1425             


Ser Gln  Glu Glu Pro Pro Gly  Ser Gln Gly Pro His  Arg His Leu 
    1430                 1435                 1440             


Glu Arg  Ser Trp Ser Ser Gln  Glu Gly Gly Leu Gly  Pro Gly Gly 
    1445                 1450                 1455             


Trp Trp  Gly Cys Gly Glu Pro  Ser Leu Gly Ala Ala  Lys Ala Pro 
    1460                 1465                 1470             


Glu Gly  Ala Trp Gly Gly Thr  Ser Arg Glu Tyr Lys  Glu Ser Trp 
    1475                 1480                 1485             


Gly Gln  Pro Glu Ala Trp Glu  Glu Lys Pro Thr His  Glu Leu Pro 
    1490                 1495                 1500             


Arg Glu  Leu Gly Lys Arg Ser  Pro Leu Thr Ser Pro  Pro Glu Asn 
    1505                 1510                 1515             


Trp Gly  Gly Pro Ala Glu Ser  Ser Gln Ser Trp His  Ser Gly Thr 
    1520                 1525                 1530             


Pro Thr  Ala Val Gly Trp Gly  Ala Glu Gly Ala Cys  Pro Tyr Pro 
    1535                 1540                 1545             


Arg Gly  Ser Glu Arg Arg Pro  Glu Leu Asp Trp Arg  Asp Leu Leu 
    1550                 1555                 1560             


Gly Leu  Leu Arg Ala Pro Gly  Glu Gly Val Trp Ala  Arg Val Pro 
    1565                 1570                 1575             


Ser Leu  Asp Trp Glu Gly Leu  Leu Glu Leu Leu Gln  Ala Arg Leu 
    1580                 1585                 1590             


Pro Arg  Lys Asp Pro Ala Gly  His Arg Asp Asp Leu  Ala Arg Ala 
    1595                 1600                 1605             


Leu Gly  Pro Glu Leu Gly Pro  Pro Gly Thr Asn Asp  Val Pro Glu 
    1610                 1615                 1620             


Gln Glu  Ser His Ser Gln Pro  Glu Gly Trp Ala Glu  Ala Thr Pro 
    1625                 1630                 1635             


Val Asn  Gly His Ser Pro Ala  Leu Gln Ser Gln Ser  Pro Val Gln 
    1640                 1645                 1650             


Leu Pro  Ser Pro Ala Cys Thr  Ser Thr Gln Trp Pro  Lys Ile Lys 
    1655                 1660                 1665             


Val Thr  Arg Gly Pro Ala Thr  Ala Thr Leu Ala Gly  Leu Glu Gln 
    1670                 1675                 1680             


Thr Gly  Pro Leu Gly Ser Arg  Ser Thr Ala Lys Gly  Pro Ser Leu 
    1685                 1690                 1695             


Pro Glu  Leu Gln Phe Gln Pro  Glu Glu Pro Glu Glu  Ser Glu Pro 
    1700                 1705                 1710             


Ser Arg  Gly Gln Asp Pro Leu  Thr Asp Gln Lys Gln  Ala Asp Ser 
    1715                 1720                 1725             


Ala Asp  Lys Arg Pro Ala Glu  Gly Lys Ala Gly Ser  Pro Leu Lys 
    1730                 1735                 1740             


Gly Arg  Leu Val Thr Ser Trp  Arg Met Pro Gly Asp  Arg Pro Thr 
    1745                 1750                 1755             


Leu Phe  Asn Pro Phe Leu Leu  Ser Leu Gly Val Leu  Arg Trp Arg 
    1760                 1765                 1770             


Arg Pro  Asp Leu Leu Asn Phe  Lys Lys Gly Trp Met  Ser Ile Leu 
    1775                 1780                 1785             


Asp Glu  Pro Gly Glu Pro Pro  Ser Pro Ser Leu Thr  Thr Thr Ser 
    1790                 1795                 1800             


Thr Ser  Gln Trp Lys Lys His  Trp Phe Val Leu Thr  Asp Ser Ser 
    1805                 1810                 1815             


Leu Lys  Tyr Tyr Arg Asp Ser  Thr Ala Glu Glu Ala  Asp Glu Leu 
    1820                 1825                 1830             


Asp Gly  Glu Ile Asp Leu Arg  Ser Cys Thr Asp Val  Thr Glu Tyr 
    1835                 1840                 1845             


Ala Val  Gln Arg Asn Tyr Gly  Phe Gln Ile His Thr  Lys Asp Ala 
    1850                 1855                 1860             


Val Tyr  Thr Leu Ser Ala Met  Thr Ser Gly Ile Arg  Arg Asn Trp 
    1865                 1870                 1875             


Ile Glu  Ala Leu Arg Lys Thr  Val Arg Pro Thr Ser  Ala Pro Asp 
    1880                 1885                 1890             


Val Thr  Lys Leu Ser Asp Ser  Asn Lys Glu Asn Ala  Leu His Ser 
    1895                 1900                 1905             


Tyr Ser  Thr Gln Lys Gly Pro  Leu Lys Ala Gly Glu  Gln Arg Ala 
    1910                 1915                 1920             


Gly Ser  Glu Val Ile Ser Arg  Gly Gly Pro Arg Lys  Ala Asp Gly 
    1925                 1930                 1935             


Gln Arg  Gln Ala Leu Asp Tyr  Val Glu Leu Ser Pro  Leu Thr Gln 
    1940                 1945                 1950             


Ala Ser  Pro Gln Arg Ala Arg  Thr Pro Ala Arg Thr  Pro Asp Arg 
    1955                 1960                 1965             


Leu Ala  Lys Gln Glu Glu Leu  Glu Arg Asp Leu Ala  Gln Arg Ser 
    1970                 1975                 1980             


Glu Glu  Arg Arg Lys Trp Phe  Glu Ala Thr Asp Ser  Arg Thr Pro 
    1985                 1990                 1995             


Glu Val  Pro Ala Gly Glu Gly  Pro Arg Arg Gly Leu  Gly Ala Pro 
    2000                 2005                 2010             


Leu Thr  Glu Asp Gln Gln Asn  Arg Leu Ser Glu Glu  Ile Glu Lys 
    2015                 2020                 2025             


Lys Trp  Gln Glu Leu Glu Lys  Leu Pro Leu Arg Glu  Asn Lys Arg 
    2030                 2035                 2040             


Val Pro  Leu Thr Ala Leu Leu  Asn Gln Ser Arg Gly  Glu Arg Arg 
    2045                 2050                 2055             


Gly Pro  Pro Ser Asp Gly His  Glu Ala Leu Glu Lys  Glu Val Gln 
    2060                 2065                 2070             


Ala Leu  Arg Ala Gln Leu Glu  Ala Trp Arg Leu Gln  Gly Glu Ala 
    2075                 2080                 2085             


Pro Gln  Ser Ala Leu Arg Ser  Gln Glu Asp Gly His  Ile Pro Pro 
    2090                 2095                 2100             


Gly Tyr  Ile Ser Gln Glu Ala  Cys Glu Arg Ser Leu  Ala Glu Met 
    2105                 2110                 2115             


Glu Ser  Ser His Gln Gln Val  Met Glu Glu Leu Gln  Arg His His 
    2120                 2125                 2130             


Glu Arg  Glu Leu Gln Arg Leu  Gln Gln Glu Lys Glu  Trp Leu Leu 
    2135                 2140                 2145             


Ala Glu  Glu Thr Ala Ala Thr  Ala Ser Ala Ile Glu  Ala Met Lys 
    2150                 2155                 2160             


Lys Ala  Tyr Gln Glu Glu Leu  Ser Arg Glu Leu Ser  Lys Thr Arg 
    2165                 2170                 2175             


Ser Leu  Gln Gln Gly Pro Asp  Gly Leu Arg Lys Gln  His Gln Ser 
    2180                 2185                 2190             


Asp Val  Glu Ala Leu Lys Arg  Glu Leu Gln Val Leu  Ser Glu Gln 
    2195                 2200                 2205             


Tyr Ser  Gln Lys Cys Leu Glu  Ile Gly Ala Leu Met  Arg Gln Ala 
    2210                 2215                 2220             


Glu Glu  Arg Glu His Thr Leu  Arg Arg Cys Gln Gln  Glu Gly Gln 
    2225                 2230                 2235             


Glu Leu  Leu Arg His Asn Gln  Glu Leu His Gly Arg  Leu Ser Glu 
    2240                 2245                 2250             


Glu Ile  Asp Gln Leu Arg Gly  Phe Ile Ala Ser Gln  Gly Met Gly 
    2255                 2260                 2265             


Asn Gly  Cys Gly Arg Ser Asn  Glu Arg Ser Ser Cys  Glu Leu Glu 
    2270                 2275                 2280             


Val Leu  Leu Arg Val Lys Glu  Asn Glu Leu Gln Tyr  Leu Lys Lys 
    2285                 2290                 2295             


Glu Val  Gln Cys Leu Arg Asp  Glu Leu Gln Met Met  Gln Lys Asp 
    2300                 2305                 2310             


Lys Arg  Phe Thr Ser Gly Lys  Tyr Gln Asp Val Tyr  Val Glu Leu 
    2315                 2320                 2325             


Ser His  Ile Lys Thr Arg Ser  Glu Arg Glu Ile Glu  Gln Leu Lys 
    2330                 2335                 2340             


Glu His  Leu Arg Leu Ala Met  Ala Ala Leu Gln Glu  Lys Glu Ser 
    2345                 2350                 2355             


Met Arg  Asn Ser Leu Ala Glu  
    2360                 2365 

<210>  554
<211>  4753
<212>  DNA
<213>  Homo sapiens

<400>  554
ttttatgggc ggatggaagg ggccggggca gcgtcgggga aaggaagggc cggaggcgcg     60

gcggcgggcg gccgagaggg gcggcggcgg cggcggcggc ggggttcccg cgccgcggag    120

cccggcccga gagccgcgtc cacgttcctg cctcctgctc ccgccgccct ggggcgccgc    180

catgacgccc gatctgctca acttcaagaa gggatggatg tcgatcttgg acgagcctgg    240

agagcctccc tccccctcgc tcaccaccac ctctacttcg cagtggaaga aacattggtt    300

tgtgctgaca gattcaagtc tcaaatatta cagagactcc actgctgagg aggcagatga    360

gctggatggt gagatcgacc tgcgttcctg cacggatgtc actgagtacg cggtgcagcg    420

caactatggc ttccagatcc acaccaagga tgctgtctat accttgtcgg ccatgacctc    480

aggcatccgg cggaactgga tcgaggctct gagaaagacc gtacgtccaa cttcagcccc    540

agatgtcacc aagctctcgg actctaacaa ggagaacgcg ctgcacagct acagcaccca    600

gaagggcccc ctgaaggcag gggagcagcg ggcgggctct gaggtcatca gccggggtgg    660

ccctcggaag gcggacgggc agcgtcaggc cttggactac gtggagctct cgccgctgac    720

ccaggcttcc ccgcagcggg cccgcacccc agcccgcact cctgaccgcc tggccaagca    780

ggaggagctg gagcgggacc tggcccagcg ctccgaggag cggcgcaagt ggtttgaggc    840

cacagacagc aggaccccag aggtgcctgc tggtgagggg ccgcgccggg gcctgggtgc    900

ccccctgact gaggaccagc aaaaccggct tagtgaggag atcgagaaga agtggcagga    960

gctggagaag ctgcccctgc gggagaataa gcgggtgccc ctcactgccc tgctcaacca   1020

aagccgcgga gagcgccgag ggcccccaag tgacggccac gaggcactgg agaaggaggt   1080

tcaggctctt cgggcccagc tggaggcgtg gcgtctccaa ggggaggctc ctcagagtgc   1140

actgagatcc caggaggatg gccacatccc cccgggctac atctcacagg aggcatgtga   1200

gcgcagcctg gcagagatgg agtcctcgca ccagcaggtg atggaggagc tgcagcggca   1260

ccacgagcgg gagctgcagc gcctgcagca ggagaaggag tggctcctgg ctgaggagac   1320

ggcagccacg gcctcagcca ttgaagccat gaagaaggcc taccaggaag agctgagccg   1380

agagctgagc aaaacacgga gtctccagca gggcccggat ggcctccgga agcagcacca   1440

gtcagatgtg gaggcactga agcgagagct gcaggtgcta tcggagcagt actcgcagaa   1500

gtgcctggag attggggcac tcatgcggca ggctgaggag cgcgagcaca cgctgcgccg   1560

ctgccagcag gagggccagg agctgctgcg ccacaaccag gagctgcatg gccgcctgtc   1620

agaggagata gaccagctgc gcggcttcat tgcctcgcag ggcatgggca atggctgcgg   1680

gcgcagcaac gagcggagtt cctgcgagct agaggtgctg cttcgcgtaa aagaaaacga   1740

actccagtac ctaaagaagg aggtgcagtg cctccgggac gagctccaga tgatgcagaa   1800

ggacaagcgc ttcacctcgg gaaagtacca ggacgtctat gtggagctga gccacatcaa   1860

gacacggtct gagcgggaga tcgagcagct gaaggagcac ctgcgtcttg ccatggccgc   1920

cctccaggag aaggagtcga tgcgcaacag cctggctgag tagaggtccc gcccagctgc   1980

agaccctcca ggctggagga ccagccgccc tccttccctc ctggatggaa gtaaaaagcc   2040

aagctttctc cccaccctct gtgggccaca cgtgcacttg cacccaccac acacacacac   2100

acacacacac acacacacac agacacacag acacatacgc acacacgtgc acacatgtac   2160

acacggatac acacacacac acacacactg catatctgag cgcgcccctc gcactgggtc   2220

tcaccttgca ccttcttcag gattttatat gtgaagagat ttttatatag atttttttcc   2280

tttttttcca aaacacttta tactttaaaa aaaaaaaaaa aaagcaattc ctggtggctg   2340

tgtgcctcca accctggtcc ccctctgtct ccagccaccc tctgcttggg cttctgagct   2400

ggtggccctg gcccagaggt ctggcggagg cccaggcagc agccatggcg gggtgtctct   2460

acaggggaga ggcgggagcc tgccaccctc ttcctgccct acctcctact aacacttcct   2520

gccccatttg gacccgtacc atggggctca ggacagaggg agctagcagc tggcctccat   2580

ggccccacag cctccttcga ggctgtgctg ggtgcagaac cgccagagcc acccaaaagg   2640

tgtttctctt ctgctccctg aacctcttaa cttaataaaa cgttccagca gctctggtgt   2700

cctagatggc tggcagaaca ggaatggaga ttggggtttc ttgaagtggc ttccccactc   2760

acaccctacc cacaccccac ccttcctaaa gcagcggcct ctaggcttct gagggtgggg   2820

ctgaaaatcc aaggtctccc ttagtacaga ctgtgacgcc cccagtgtgg cttgcaggct   2880

agtggcagcg gaagcatgtg ggaaatagca agtccagtcc caccccaacc tactgaacca   2940

gcgtctgcat tttaacaggg tgccccagtg attcacgtga ccttcaaagt ctgaggagcc   3000

ctggagtagg gcccagggcc caggcctgag agagaggcct ggggctaaga ctagccctga   3060

ccatgacctt gggcaagtca cacccctcac tgagcctcag tttgcttctc catcaaatgg   3120

gtgtttttct ttcagtccca gtcctctcct gaggcttttc ccagaggtca tgcccagccc   3180

tgggcagggg tgagggcagg gttgtggctg ccaggcacag gtccagcggg ctgggagtcc   3240

tcaccatggc tggctgtgct gattatggtt gcatggggct gggaagaggt cccatttctg   3300

agccacagaa acaggccaca tccagtaggg gtcctggaag gctgtgagaa cccagaggag   3360

accctgaccc agcctgcagg tagaagactg cctttggagg cagctttgaa agatgactct   3420

tccagatgga agaatcagga agggccttcc cacgtggagg caccagcagg agcaaacgtc   3480

cctggtgtgt tcaggcaaag agccacagga gagtgacctc gtggagtggg aagagattgt   3540

ttcccattcc cttgccaggg attggttgag gaatggacaa ggcttgcagt tcacgcaagc   3600

cagtgaaatg cgaggggaag tcttgggagt ggggtggagg aggtcatctg ggaagggtgt   3660

ccttggtctt aaaaagaggc acaagaggcc gggcgcggtg gctcttgcct attatcctag   3720

cactttggga ggccaaggca gggggatcac ttgaggtcag gagttcgaga ccagcctggc   3780

caacatggtg aaaccccgtc tctactaaaa atacaaaaaa ttagccagac gtggtgccaa   3840

gcacctgtaa tcccagctac tcaggaggct gaggcaggag aatcacttga acccaggagg   3900

cagaagttgc agtgagccaa gatcgcgcca ctgcactcca gcctgtgtga caagggcgaa   3960

actccatctc aaaaaaaaag ggggagggtg gcgcaaggag aggacacctc tctcctggcc   4020

ctgtcgccat cttccctcat caatagctaa aaatggcaaa gaagaaagag ccaggacccc   4080

gtgccatcaa atcctccggc cttgtgctgc cctgtctcgg cactgcttgc cttaggagat   4140

caggagtgtt cctagccact gggagatggg atgcctgcca ctggcagctc tgccgtccat   4200

cctcaccatc ccaccgtccc cccaagacag ctctccatcc catcctctgc ctcccttcta   4260

gcctcaacct aactcagggc tcccccgtct cacacctggg ttgcaggaac atcctcttca   4320

ccaacccccc tcccatccct cctcagggct gcctagggca gctacaaaaa ccaggccagc   4380

ctctgaaagg tgctccacat ctcattaaaa accgtgaaat cgcactgccc cactatcaga   4440

atagctcaga ggagaaggtc tgccagtacc aagtgctggt ggggatacgg agaagagcag   4500

ctcccaggcg ctgctggtgc aaatgtgctt tgttgcaccc acggcaggaa actgaccagc   4560

ttctcatcaa gttaaatacg catctaccct atggcctagc atttccactc ttgcttacac   4620

atccaggaga aatgagtcct tacatgcaca aaaggatgag taccgtaata ctcacatcag   4680

caaataaaca atacagctgt gtgtcagtag tagaatgaat aaattgtggt cgattcataa   4740

aaaaaaaaaa aaa                                                      4753


<210>  555
<211>  652
<212>  PRT
<213>  Homo sapiens

<400>  555


Met Gly Gly Trp Lys Gly Pro Gly Gln Arg Arg Gly Lys Glu Gly Pro 
1               5                   10                  15      


Glu Ala Arg Arg Arg Ala Ala Glu Arg Gly Gly Gly Gly Gly Gly Gly 
            20                  25                  30          


Gly Val Pro Ala Pro Arg Ser Pro Ala Arg Glu Pro Arg Pro Arg Ser 
        35                  40                  45              


Cys Leu Leu Leu Pro Pro Pro Trp Gly Ala Ala Met Thr Pro Asp Leu 
    50                  55                  60                  


Leu Asn Phe Lys Lys Gly Trp Met Ser Ile Leu Asp Glu Pro Gly Glu 
65                  70                  75                  80  


Pro Pro Ser Pro Ser Leu Thr Thr Thr Ser Thr Ser Gln Trp Lys Lys 
                85                  90                  95      


His Trp Phe Val Leu Thr Asp Ser Ser Leu Lys Tyr Tyr Arg Asp Ser 
            100                 105                 110         


Thr Ala Glu Glu Ala Asp Glu Leu Asp Gly Glu Ile Asp Leu Arg Ser 
        115                 120                 125             


Cys Thr Asp Val Thr Glu Tyr Ala Val Gln Arg Asn Tyr Gly Phe Gln 
    130                 135                 140                 


Ile His Thr Lys Asp Ala Val Tyr Thr Leu Ser Ala Met Thr Ser Gly 
145                 150                 155                 160 


Ile Arg Arg Asn Trp Ile Glu Ala Leu Arg Lys Thr Val Arg Pro Thr 
                165                 170                 175     


Ser Ala Pro Asp Val Thr Lys Leu Ser Asp Ser Asn Lys Glu Asn Ala 
            180                 185                 190         


Leu His Ser Tyr Ser Thr Gln Lys Gly Pro Leu Lys Ala Gly Glu Gln 
        195                 200                 205             


Arg Ala Gly Ser Glu Val Ile Ser Arg Gly Gly Pro Arg Lys Ala Asp 
    210                 215                 220                 


Gly Gln Arg Gln Ala Leu Asp Tyr Val Glu Leu Ser Pro Leu Thr Gln 
225                 230                 235                 240 


Ala Ser Pro Gln Arg Ala Arg Thr Pro Ala Arg Thr Pro Asp Arg Leu 
                245                 250                 255     


Ala Lys Gln Glu Glu Leu Glu Arg Asp Leu Ala Gln Arg Ser Glu Glu 
            260                 265                 270         


Arg Arg Lys Trp Phe Glu Ala Thr Asp Ser Arg Thr Pro Glu Val Pro 
        275                 280                 285             


Ala Gly Glu Gly Pro Arg Arg Gly Leu Gly Ala Pro Leu Thr Glu Asp 
    290                 295                 300                 


Gln Gln Asn Arg Leu Ser Glu Glu Ile Glu Lys Lys Trp Gln Glu Leu 
305                 310                 315                 320 


Glu Lys Leu Pro Leu Arg Glu Asn Lys Arg Val Pro Leu Thr Ala Leu 
                325                 330                 335     


Leu Asn Gln Ser Arg Gly Glu Arg Arg Gly Pro Pro Ser Asp Gly His 
            340                 345                 350         


Glu Ala Leu Glu Lys Glu Val Gln Ala Leu Arg Ala Gln Leu Glu Ala 
        355                 360                 365             


Trp Arg Leu Gln Gly Glu Ala Pro Gln Ser Ala Leu Arg Ser Gln Glu 
    370                 375                 380                 


Asp Gly His Ile Pro Pro Gly Tyr Ile Ser Gln Glu Ala Cys Glu Arg 
385                 390                 395                 400 


Ser Leu Ala Glu Met Glu Ser Ser His Gln Gln Val Met Glu Glu Leu 
                405                 410                 415     


Gln Arg His His Glu Arg Glu Leu Gln Arg Leu Gln Gln Glu Lys Glu 
            420                 425                 430         


Trp Leu Leu Ala Glu Glu Thr Ala Ala Thr Ala Ser Ala Ile Glu Ala 
        435                 440                 445             


Met Lys Lys Ala Tyr Gln Glu Glu Leu Ser Arg Glu Leu Ser Lys Thr 
    450                 455                 460                 


Arg Ser Leu Gln Gln Gly Pro Asp Gly Leu Arg Lys Gln His Gln Ser 
465                 470                 475                 480 


Asp Val Glu Ala Leu Lys Arg Glu Leu Gln Val Leu Ser Glu Gln Tyr 
                485                 490                 495     


Ser Gln Lys Cys Leu Glu Ile Gly Ala Leu Met Arg Gln Ala Glu Glu 
            500                 505                 510         


Arg Glu His Thr Leu Arg Arg Cys Gln Gln Glu Gly Gln Glu Leu Leu 
        515                 520                 525             


Arg His Asn Gln Glu Leu His Gly Arg Leu Ser Glu Glu Ile Asp Gln 
    530                 535                 540                 


Leu Arg Gly Phe Ile Ala Ser Gln Gly Met Gly Asn Gly Cys Gly Arg 
545                 550                 555                 560 


Ser Asn Glu Arg Ser Ser Cys Glu Leu Glu Val Leu Leu Arg Val Lys 
                565                 570                 575     


Glu Asn Glu Leu Gln Tyr Leu Lys Lys Glu Val Gln Cys Leu Arg Asp 
            580                 585                 590         


Glu Leu Gln Met Met Gln Lys Asp Lys Arg Phe Thr Ser Gly Lys Tyr 
        595                 600                 605             


Gln Asp Val Tyr Val Glu Leu Ser His Ile Lys Thr Arg Ser Glu Arg 
    610                 615                 620                 


Glu Ile Glu Gln Leu Lys Glu His Leu Arg Leu Ala Met Ala Ala Leu 
625                 630                 635                 640 


Gln Glu Lys Glu Ser Met Arg Asn Ser Leu Ala Glu 
                645                 650         

<210>  556
<211>  1743
<212>  DNA
<213>  Homo sapiens

<400>  556
ttttatgggc ggatggaagg ggccggggca gcgtcgggga aaggaagggc cggaggcgcg     60

gcggcgggcg gccgagaggg gcggcggcgg cggcggcggc ggggttcccg cgccgcggag    120

cccggcccga gagccgcgtc cacgttcctg cctcctgctc ccgccgccct ggggcgccgc    180

catgacgccc gatctgctca acttcaagaa gggatggatg tcgatcttgg acgagcctgg    240

agagcctccc tccccctcgc tcaccaccac ctctacttcg cagtggaaga aacattggtt    300

tgtgctgaca gattcaagtc tcaaatatta cagagactcc actgctgagg aggcagatga    360

gctggatggt gagatcgacc tgcgttcctg cacggatgtc actgagtacg cggtgcagcg    420

caactatggc ttccagatcc acaccaagga tgctgtctat accttgtcgg ccatgacctc    480

aggcatccgg cggaactgga tcgaggctct gagaaagacc gtacgtccaa cttcagcccc    540

agatgtcacc aagctctcgg actctaacaa ggagaacgcg ctgcacagct acagcaccca    600

gaagggcccc ctgaaggcag gggagcagcg ggcgggctct gaggtcatca gccggggtgg    660

ccctcggaag gcggacgggc agcgtcaggc cttggactac gtggagctct cgccgctgac    720

ccaggcttcc ccgcagcggg cccgcacccc agcccgcact cctgaccgcc tggccaagca    780

ggaggagctg gagcgggacc tggcccagcg ctccgaggag cggcgcaagt ggtttgaggc    840

cacagacagc aggaccccag aggtgcctgc tggtgagggg ccgcgccggg gcctgggtgc    900

ccccctgact gaggaccagc aaaaccggct tagtgaggag atcgagaaga agtggcagga    960

gctggagaag ctgcccctgc gggagaataa gcgggtgccc ctcactgccc tgctcaacca   1020

aagccgcgga gagcgccgag ggcccccaag tgacggccac gaggcactgg agaaggaggt   1080

tcaggctctt cgggcccagc tggaggcgtg gcgtctccaa ggggaggctc ctcagagtgc   1140

actgagatcc caggaggatg gccacatccc cccgggctac atctcacagc tggtgggcgt   1200

gatcactgtg cccgttttac agacaaggcc actgagctct gagaggttat gtgacttgcc   1260

caaggtcacc ccgcctgcag gtctcaaagg tgggatttga gcgagggtcc ggctgactgc   1320

agagcctgtg tgtgagtccc cgtgtgacac tctgcacttg gacccttgcc ccggggaagt   1380

ggggggctag tggccccgag agtcactccc tgaacacagg gaaatcctgc cgaggcccac   1440

tgggccaagg ccccacacaa ggaggtctgc aggacagggg agcctccagt agccctcaga   1500

gaatgcaccg tccgcctagg acagcggttc tcaacggggt ccattttgtc ccccttgggg   1560

acatttggct gtgtctggga atacttctgg ttgtcacaac taggacaaac taactctcta   1620

gaaaaaacgt gtgtgtgtac acatatataa gtttattata aattttacca ataaaaacaa   1680

tgcttagtac acaatttaca aataaaaata tataatttta ttgtgaaaaa aaaaaaaaaa   1740

aaa                                                                 1743


<210>  557
<211>  431
<212>  PRT
<213>  Homo sapiens

<400>  557


Met Gly Gly Trp Lys Gly Pro Gly Gln Arg Arg Gly Lys Glu Gly Pro 
1               5                   10                  15      


Glu Ala Arg Arg Arg Ala Ala Glu Arg Gly Gly Gly Gly Gly Gly Gly 
            20                  25                  30          


Gly Val Pro Ala Pro Arg Ser Pro Ala Arg Glu Pro Arg Pro Arg Ser 
        35                  40                  45              


Cys Leu Leu Leu Pro Pro Pro Trp Gly Ala Ala Met Thr Pro Asp Leu 
    50                  55                  60                  


Leu Asn Phe Lys Lys Gly Trp Met Ser Ile Leu Asp Glu Pro Gly Glu 
65                  70                  75                  80  


Pro Pro Ser Pro Ser Leu Thr Thr Thr Ser Thr Ser Gln Trp Lys Lys 
                85                  90                  95      


His Trp Phe Val Leu Thr Asp Ser Ser Leu Lys Tyr Tyr Arg Asp Ser 
            100                 105                 110         


Thr Ala Glu Glu Ala Asp Glu Leu Asp Gly Glu Ile Asp Leu Arg Ser 
        115                 120                 125             


Cys Thr Asp Val Thr Glu Tyr Ala Val Gln Arg Asn Tyr Gly Phe Gln 
    130                 135                 140                 


Ile His Thr Lys Asp Ala Val Tyr Thr Leu Ser Ala Met Thr Ser Gly 
145                 150                 155                 160 


Ile Arg Arg Asn Trp Ile Glu Ala Leu Arg Lys Thr Val Arg Pro Thr 
                165                 170                 175     


Ser Ala Pro Asp Val Thr Lys Leu Ser Asp Ser Asn Lys Glu Asn Ala 
            180                 185                 190         


Leu His Ser Tyr Ser Thr Gln Lys Gly Pro Leu Lys Ala Gly Glu Gln 
        195                 200                 205             


Arg Ala Gly Ser Glu Val Ile Ser Arg Gly Gly Pro Arg Lys Ala Asp 
    210                 215                 220                 


Gly Gln Arg Gln Ala Leu Asp Tyr Val Glu Leu Ser Pro Leu Thr Gln 
225                 230                 235                 240 


Ala Ser Pro Gln Arg Ala Arg Thr Pro Ala Arg Thr Pro Asp Arg Leu 
                245                 250                 255     


Ala Lys Gln Glu Glu Leu Glu Arg Asp Leu Ala Gln Arg Ser Glu Glu 
            260                 265                 270         


Arg Arg Lys Trp Phe Glu Ala Thr Asp Ser Arg Thr Pro Glu Val Pro 
        275                 280                 285             


Ala Gly Glu Gly Pro Arg Arg Gly Leu Gly Ala Pro Leu Thr Glu Asp 
    290                 295                 300                 


Gln Gln Asn Arg Leu Ser Glu Glu Ile Glu Lys Lys Trp Gln Glu Leu 
305                 310                 315                 320 


Glu Lys Leu Pro Leu Arg Glu Asn Lys Arg Val Pro Leu Thr Ala Leu 
                325                 330                 335     


Leu Asn Gln Ser Arg Gly Glu Arg Arg Gly Pro Pro Ser Asp Gly His 
            340                 345                 350         


Glu Ala Leu Glu Lys Glu Val Gln Ala Leu Arg Ala Gln Leu Glu Ala 
        355                 360                 365             


Trp Arg Leu Gln Gly Glu Ala Pro Gln Ser Ala Leu Arg Ser Gln Glu 
    370                 375                 380                 


Asp Gly His Ile Pro Pro Gly Tyr Ile Ser Gln Leu Val Gly Val Ile 
385                 390                 395                 400 


Thr Val Pro Val Leu Gln Thr Arg Pro Leu Ser Ser Glu Arg Leu Cys 
                405                 410                 415     


Asp Leu Pro Lys Val Thr Pro Pro Ala Gly Leu Lys Gly Gly Ile 
            420                 425                 430     

<210>  558
<211>  5706
<212>  DNA
<213>  Homo sapiens

<400>  558
atttaagcga ttttttttcc ctccttcatc tccgggcctc ggataagatg acggcttggg     60

tgatgcacga aataacgcac gtgattgatt agacctggct tggcttggct agggaacgat    120

ccaggcgcgc tggagacccc gcgtgaagat gaaatgacgg ctgccttgga gttttcataa    180

gaaattgtcc ctggaggtgt tggatgatca cagcttcctt ggagcattgc agttgctgga    240

atccagtttc aggattaagg gagggctgcc tccttgcaat gggctgccaa gaaaacggct    300

gtgcttgttc ttaacctcag gctctgtctg tgatcagtct gagagtctct cccaggtcta    360

ctgctccctg gaaagcccta tctctctgca ggctcgcctc tgggctttgt ctccttggag    420

ccacatcact gggacagctg tggatgtgga tgcagatttg aaccatgtca cggccccagg    480

gactgctatg gcttcctttg ttgttcaccc cggtctgcgt catgttaaac tccaatgtcc    540

tcctgtggtt aactgctctt gccatcaagt tcaccctcat tgacagccaa gcacagtatc    600

cagttgtcaa cacaaattat ggcaaaatcc ggggcctaag aacaccgtta cccaatgaga    660

tcttgggtcc agtggagcag tacttagggg tcccctatgc ctcacccccc actggagaga    720

ggcggtttca gcccccagaa cccccgtcct cctggactgg catccgaaat actactcagt    780

ttgctgctgt gtgcccccag cacctggatg agagatcctt actgcatgac atgctgccca    840

tctggtttac cgccaatttg gatactttga tgacctatgt tcaagatcaa aatgaagact    900

gcctttactt aaacatctac gtgcccacgg aagatgatat tcatgatcag aacagtaaga    960

agcccgtcat ggtctatatc catgggggat cttacatgga gggcaccggc aacatgattg   1020

acggcagcat tttggcaagc tacggaaacg tcatcgtgat caccattaac taccgtctgg   1080

gaatactagg gtttttaagt accggtgacc aggcagcaaa aggcaactat gggctcctgg   1140

atcagattca agcactgcgg tggattgagg agaatgtggg agcctttggc ggggacccca   1200

agagagtgac catctttggc tcgggggctg gggcctcctg tgtcagcctg ttgaccctgt   1260

cccactactc agaaggtctc ttccagaagg ccatcattca gagcggcacc gccctgtcca   1320

gctgggcagt gaactaccag ccggccaagt acactcggat attggcagac aaggtcggct   1380

gcaacatgct ggacaccacg gacatggtag aatgcctgcg gaacaagaac tacaaggagc   1440

tcatccagca gaccatcacc ccggccacct accacatagc cttcgggccg gtgatcgacg   1500

gcgacgtcat cccagacgac ccccagatcc tgatggagca aggcgagttc ctcaactacg   1560

acatcatgct gggcgtcaac caaggggaag gcctgaagtt cgtggacggc atcgtggata   1620

acgaggacgg tgtgacgccc aacgactttg acttctccgt gtccaacttc gtggacaacc   1680

tttacggcta ccctgaaggg aaagacactt tgcgggagac tatcaagttc atgtacacag   1740

actgggccga taaggaaaac ccggagacgc ggcggaaaac cctggtggct ctctttactg   1800

accaccagtg ggtggccccc gccgtggcca ccgccgacct gcacgcgcag tacggctccc   1860

ccacctactt ctatgccttc tatcatcact gccaaagcga aatgaagccc agctgggcag   1920

attcggccca tggtgatgag gtcccctatg tcttcggcat ccccatgatc ggtcccaccg   1980

agctcttcag ttgtaacttt tccaagaacg acgtcatgct cagcgccgtg gtcatgacct   2040

actggacgaa cttcgccaaa actggtgatc caaatcaacc agttcctcag gataccaagt   2100

tcattcacac aaaacccaac cgctttgaag aagtggcctg gtccaagtat aatcccaaag   2160

accagctcta tctgcatatt ggcttgaaac ccagagtgag agatcactac cgggcaacga   2220

aagtggcttt ctggttggaa ctcgttcctc atttgcacaa cttgaacgag atattccagt   2280

atgtttcaac aaccacaaag gttcctccac cagacatgac atcatttccc tatggcaccc   2340

ggcgatctcc cgccaagata tggccaacca ccaaacgccc agcaatcact cctgccaaca   2400

atcccaaaca ctctaaggac cctcacaaaa cagggcctga ggacacaact gtcctcattg   2460

aaaccaaacg agattattcc accgaattaa gtgtcaccat tgccgtcggg gcgtcgctcc   2520

tcttcctcaa catcttagct tttgcggcgc tgtactacaa aaaggacaag aggcgccatg   2580

agactcacag gcgccccagt ccccagagaa acaccacaaa tgatatcgct cacatccaga   2640

acgaagagat catgtctctg cagatgaagc agctggaaca cgatcacgag tgtgagtcgc   2700

tgcaggcaca cgacacactg aggctcacct gcccgccaga ctacaccctc acgctgcgcc   2760

ggtcgccaga tgacatccca cttatgacgc caaacaccat caccatgatt ccaaacacac   2820

tgacggggat gcagcctttg cacactttta acaccttcag tggaggacaa aacagtacaa   2880

atttacccca cggacattcc accactagag tatagctttg ccctatttcc cttcctatcc   2940

ctctgcccta cccgctcagc aacatagaag agggaaggaa agagagaagg aaagagagag   3000

agaaagaaag tctccagacc aggaatgttt ttgtcccact gacttaagac aaaaatgcaa   3060

aaaggcagtc atcccatccc ggcagaccct tatcgttggt gttttccagt attacaagat   3120

caacttctga ccctgtgaaa tgtgagaagt acacatttct gttaaaataa ctgctttaag   3180

atctctacca ctccaatcga tgtttagtgt gataggacat caccatttca aggccccggg   3240

tgtttccaac gtcatggaag cagctgacac ttctgaaact cagccaagga cacttgatat   3300

tttttaatta caatggaagt ttaaacattt ctttctgtgc cacacaatgg atggctctcc   3360

ttaagtgaag aaagagtcaa tgagattttg cccagcacat ggagctgtaa tccagagaga   3420

aggaaacgta gaaatttatt attaaaagaa tggactgtgc agcgaaatct gtacggttct   3480

gtgcaaagag gtgttttgcc agcctgaact atatttaaga gactttgtaa aaaagaaaaa   3540

tgtatatagc tgtgagttta aacaaaaacc acaaacagac aaacaagaaa aaaagctttt   3600

attggtgttt tcactttgaa agagctttta gcaaggttgt gcttttcatt gtgctctgta   3660

cgtatataaa tatatatata tatacacaca cacacacaca ttagtcatat cacctctgtt   3720

tcctccccaa caaaagaggc ttttcttctt aattacttgt ggtaaacaaa gacatgggat   3780

tttcttacat gagattctca tttgtaggag gatgtgatgt cccacagaag acccagacgg   3840

tctgtgtggc ctatttcccc cgtcaggttg cacaggtgca tgcaagagca ttcttaggag   3900

accactgttt tgaaaaactt ttgacttgta cgtgttagcc ttcatgaaat tgcagtacag   3960

agatgggtcc ccaaagtgga gtgtatttac agcttgttaa attagagaca tgcacacaca   4020

aagaatcagt agggagaaac aaaaatacaa gtcccgttct gtagctctgg ccctttgaat   4080

atgtttagga agagttgctt cccatttcag ggccctgcca aaaaaagaag aaagcttgcc   4140

tttggtgggg ctatgcccct tggagtaaat acggctctgt gttccctagc agctgcggga   4200

gggtttggcc gatgaagtac ctgctcagct tagctaatca gattgaagga agacatgtgt   4260

ctttcctttt tgtttaagca ctcggtccct tatttatcag taagcaggtt tttaaaaatc   4320

ttttatatca tttatgggat caaacatatg attgtctgaa aacatcactt tttgtggatt   4380

tgtgtatccg gtcaccaaac ggtgaatatt atagaagaat gggggaagaa aggatagaat   4440

attaaaactg ctttgcatgg gttttctggg aaattaggat aacttcactg agaagacatt   4500

gaatggaaat tattcaccca ttttaaattg gtgacctagg gatcagagat ttgtctttcc   4560

aacagcttgt cattttttca tttctcttct catttttcag gaaagttttg agtgttataa   4620

ggtggaagga aacatagtag caatggatac ttttttgaaa aattattgca ttaccaagaa   4680

acagtagcca aagatatttg aagatcatgt tcctcggctc cattgtgggt tattctagaa   4740

atccagtctt aaatctctcc gctaaagtgg acattcccca taaaaattgt ccagctgcct   4800

ggctcttttg caataacaac ctttgattac tgaatcccta cactcaaact atagtgatat   4860

atcagtgttt gagagtgacc tctagaaaaa agaaaagtgt ttttagaaat gcgtacaagt   4920

cacccccaaa tcctattgct tatcttgggt taaatttgag agtgattctc tgtatataaa   4980

tatgtgaaat attattatct caacttagca cacgtgaagc aacatttctt tcctacagag   5040

aggtgtcatg gtaagatttc attccgaatt cattgtttca tagagctatg atcaggccat   5100

ttctgcaagc aatgtatgac cccacctgag caaccacaaa taggctctct gtgaaactac   5160

aaaggaagtt atgtgtggca tccatgttgg tttcgtctgt ctgtaatgtg aattccagta   5220

tttgtttagt atttccagtt gtctcctgct agcaatatgt acagtaacgc gtcaggcttg   5280

tgacatttga ataaggaaaa acagagttcc tgttaagtga ataactttag cttttacagg   5340

ggattatgat caaaagtgat tttagtacat cttaaatgat atcttatttc tacatggaaa   5400

gaagttatag aatcttcata gagttctatg agaaaaaata tacttgctat ctataaaaaa   5460

gagaaaaaag aaaaaaaatg agaaaaaagt aagaaaaaaa aaaatcctgt cctaggcttt   5520

tactcttgat cttcaaaggc acgcagggtt taatggttcc ttgggttatt attttgcagt   5580

tttgtttttt attttgcctt aagtaatgat agaagatata tatggccgga cacatatgta   5640

taaacttttc agcagcattt ttaataataa aatatcacag tattttctaa aaaaaaaaaa   5700

aaaaaa                                                              5706


<210>  559
<211>  816
<212>  PRT
<213>  Homo sapiens

<400>  559


Met Ser Arg Pro Gln Gly Leu Leu Trp Leu Pro Leu Leu Phe Thr Pro 
1               5                   10                  15      


Val Cys Val Met Leu Asn Ser Asn Val Leu Leu Trp Leu Thr Ala Leu 
            20                  25                  30          


Ala Ile Lys Phe Thr Leu Ile Asp Ser Gln Ala Gln Tyr Pro Val Val 
        35                  40                  45              


Asn Thr Asn Tyr Gly Lys Ile Arg Gly Leu Arg Thr Pro Leu Pro Asn 
    50                  55                  60                  


Glu Ile Leu Gly Pro Val Glu Gln Tyr Leu Gly Val Pro Tyr Ala Ser 
65                  70                  75                  80  


Pro Pro Thr Gly Glu Arg Arg Phe Gln Pro Pro Glu Pro Pro Ser Ser 
                85                  90                  95      


Trp Thr Gly Ile Arg Asn Thr Thr Gln Phe Ala Ala Val Cys Pro Gln 
            100                 105                 110         


His Leu Asp Glu Arg Ser Leu Leu His Asp Met Leu Pro Ile Trp Phe 
        115                 120                 125             


Thr Ala Asn Leu Asp Thr Leu Met Thr Tyr Val Gln Asp Gln Asn Glu 
    130                 135                 140                 


Asp Cys Leu Tyr Leu Asn Ile Tyr Val Pro Thr Glu Asp Asp Ile His 
145                 150                 155                 160 


Asp Gln Asn Ser Lys Lys Pro Val Met Val Tyr Ile His Gly Gly Ser 
                165                 170                 175     


Tyr Met Glu Gly Thr Gly Asn Met Ile Asp Gly Ser Ile Leu Ala Ser 
            180                 185                 190         


Tyr Gly Asn Val Ile Val Ile Thr Ile Asn Tyr Arg Leu Gly Ile Leu 
        195                 200                 205             


Gly Phe Leu Ser Thr Gly Asp Gln Ala Ala Lys Gly Asn Tyr Gly Leu 
    210                 215                 220                 


Leu Asp Gln Ile Gln Ala Leu Arg Trp Ile Glu Glu Asn Val Gly Ala 
225                 230                 235                 240 


Phe Gly Gly Asp Pro Lys Arg Val Thr Ile Phe Gly Ser Gly Ala Gly 
                245                 250                 255     


Ala Ser Cys Val Ser Leu Leu Thr Leu Ser His Tyr Ser Glu Gly Leu 
            260                 265                 270         


Phe Gln Lys Ala Ile Ile Gln Ser Gly Thr Ala Leu Ser Ser Trp Ala 
        275                 280                 285             


Val Asn Tyr Gln Pro Ala Lys Tyr Thr Arg Ile Leu Ala Asp Lys Val 
    290                 295                 300                 


Gly Cys Asn Met Leu Asp Thr Thr Asp Met Val Glu Cys Leu Arg Asn 
305                 310                 315                 320 


Lys Asn Tyr Lys Glu Leu Ile Gln Gln Thr Ile Thr Pro Ala Thr Tyr 
                325                 330                 335     


His Ile Ala Phe Gly Pro Val Ile Asp Gly Asp Val Ile Pro Asp Asp 
            340                 345                 350         


Pro Gln Ile Leu Met Glu Gln Gly Glu Phe Leu Asn Tyr Asp Ile Met 
        355                 360                 365             


Leu Gly Val Asn Gln Gly Glu Gly Leu Lys Phe Val Asp Gly Ile Val 
    370                 375                 380                 


Asp Asn Glu Asp Gly Val Thr Pro Asn Asp Phe Asp Phe Ser Val Ser 
385                 390                 395                 400 


Asn Phe Val Asp Asn Leu Tyr Gly Tyr Pro Glu Gly Lys Asp Thr Leu 
                405                 410                 415     


Arg Glu Thr Ile Lys Phe Met Tyr Thr Asp Trp Ala Asp Lys Glu Asn 
            420                 425                 430         


Pro Glu Thr Arg Arg Lys Thr Leu Val Ala Leu Phe Thr Asp His Gln 
        435                 440                 445             


Trp Val Ala Pro Ala Val Ala Thr Ala Asp Leu His Ala Gln Tyr Gly 
    450                 455                 460                 


Ser Pro Thr Tyr Phe Tyr Ala Phe Tyr His His Cys Gln Ser Glu Met 
465                 470                 475                 480 


Lys Pro Ser Trp Ala Asp Ser Ala His Gly Asp Glu Val Pro Tyr Val 
                485                 490                 495     


Phe Gly Ile Pro Met Ile Gly Pro Thr Glu Leu Phe Ser Cys Asn Phe 
            500                 505                 510         


Ser Lys Asn Asp Val Met Leu Ser Ala Val Val Met Thr Tyr Trp Thr 
        515                 520                 525             


Asn Phe Ala Lys Thr Gly Asp Pro Asn Gln Pro Val Pro Gln Asp Thr 
    530                 535                 540                 


Lys Phe Ile His Thr Lys Pro Asn Arg Phe Glu Glu Val Ala Trp Ser 
545                 550                 555                 560 


Lys Tyr Asn Pro Lys Asp Gln Leu Tyr Leu His Ile Gly Leu Lys Pro 
                565                 570                 575     


Arg Val Arg Asp His Tyr Arg Ala Thr Lys Val Ala Phe Trp Leu Glu 
            580                 585                 590         


Leu Val Pro His Leu His Asn Leu Asn Glu Ile Phe Gln Tyr Val Ser 
        595                 600                 605             


Thr Thr Thr Lys Val Pro Pro Pro Asp Met Thr Ser Phe Pro Tyr Gly 
    610                 615                 620                 


Thr Arg Arg Ser Pro Ala Lys Ile Trp Pro Thr Thr Lys Arg Pro Ala 
625                 630                 635                 640 


Ile Thr Pro Ala Asn Asn Pro Lys His Ser Lys Asp Pro His Lys Thr 
                645                 650                 655     


Gly Pro Glu Asp Thr Thr Val Leu Ile Glu Thr Lys Arg Asp Tyr Ser 
            660                 665                 670         


Thr Glu Leu Ser Val Thr Ile Ala Val Gly Ala Ser Leu Leu Phe Leu 
        675                 680                 685             


Asn Ile Leu Ala Phe Ala Ala Leu Tyr Tyr Lys Lys Asp Lys Arg Arg 
    690                 695                 700                 


His Glu Thr His Arg Arg Pro Ser Pro Gln Arg Asn Thr Thr Asn Asp 
705                 710                 715                 720 


Ile Ala His Ile Gln Asn Glu Glu Ile Met Ser Leu Gln Met Lys Gln 
                725                 730                 735     


Leu Glu His Asp His Glu Cys Glu Ser Leu Gln Ala His Asp Thr Leu 
            740                 745                 750         


Arg Leu Thr Cys Pro Pro Asp Tyr Thr Leu Thr Leu Arg Arg Ser Pro 
        755                 760                 765             


Asp Asp Ile Pro Leu Met Thr Pro Asn Thr Ile Thr Met Ile Pro Asn 
    770                 775                 780                 


Thr Leu Thr Gly Met Gln Pro Leu His Thr Phe Asn Thr Phe Ser Gly 
785                 790                 795                 800 


Gly Gln Asn Ser Thr Asn Leu Pro His Gly His Ser Thr Thr Arg Val 
                805                 810                 815     

<210>  560
<211>  5672
<212>  DNA
<213>  Homo sapiens

<400>  560
agaaggggaa ggctcctggg ctttcaatac atcctcctga atcatacctc gtttcgggtt     60

ccctagaaaa atctggacgt gtaaaaagaa ctcttaacgg ccgatgcagc tcttccaaag    120

ctaaggctgc cttggagttt tcataagaaa ttgtccctgg aggtgttgga tgatcacagc    180

ttccttggag cattgcagtt gctggaatcc agtttcagga ttaagggagg gctgcctcct    240

tgcaatgggc tgccaagaaa acggctgtgc ttgttcttaa cctcaggctc tgtctgtgat    300

cagtctgaga gtctctccca ggtctactgc tccctggaaa gccctatctc tctgcaggct    360

cgcctctggg ctttgtctcc ttggagccac atcactggga cagctgtgga tgtggatgca    420

gatttgaacc atgtcacggc cccagggact gctatggctt cctttgttgt tcaccccggt    480

ctgcgtcatg ttaaactcca atgtcctcct gtggttaact gctcttgcca tcaagttcac    540

cctcattgac agccaagcac agtatccagt tgtcaacaca aattatggca aaatccgggg    600

cctaagaaca ccgttaccca atgagatctt gggtccagtg gagcagtact taggggtccc    660

ctatgcctca ccccccactg gagagaggcg gtttcagccc ccagaacccc cgtcctcctg    720

gactggcatc cgaaatacta ctcagtttgc tgctgtgtgc ccccagcacc tggatgagag    780

atccttactg catgacatgc tgcccatctg gtttaccgcc aatttggata ctttgatgac    840

ctatgttcaa gatcaaaatg aagactgcct ttacttaaac atctacgtgc ccacggaaga    900

tgatattcat gatcagaaca gtaagaagcc cgtcatggtc tatatccatg ggggatctta    960

catggagggc accggcaaca tgattgacgg cagcattttg gcaagctacg gaaacgtcat   1020

cgtgatcacc attaactacc gtctgggaat actagggttt ttaagtaccg gtgaccaggc   1080

agcaaaaggc aactatgggc tcctggatca gattcaagca ctgcggtgga ttgaggagaa   1140

tgtgggagcc tttggcgggg accccaagag agtgaccatc tttggctcgg gggctggggc   1200

ctcctgtgtc agcctgttga ccctgtccca ctactcagaa ggtctcttcc agaaggccat   1260

cattcagagc ggcaccgccc tgtccagctg ggcagtgaac taccagccgg ccaagtacac   1320

tcggatattg gcagacaagg tcggctgcaa catgctggac accacggaca tggtagaatg   1380

cctgcggaac aagaactaca aggagctcat ccagcagacc atcaccccgg ccacctacca   1440

catagccttc gggccggtga tcgacggcga cgtcatccca gacgaccccc agatcctgat   1500

ggagcaaggc gagttcctca actacgacat catgctgggc gtcaaccaag gggaaggcct   1560

gaagttcgtg gacggcatcg tggataacga ggacggtgtg acgcccaacg actttgactt   1620

ctccgtgtcc aacttcgtgg acaaccttta cggctaccct gaagggaaag acactttgcg   1680

ggagactatc aagttcatgt acacagactg ggccgataag gaaaacccgg agacgcggcg   1740

gaaaaccctg gtggctctct ttactgacca ccagtgggtg gcccccgccg tggccaccgc   1800

cgacctgcac gcgcagtacg gctcccccac ctacttctat gccttctatc atcactgcca   1860

aagcgaaatg aagcccagct gggcagattc ggcccatggt gatgaggtcc cctatgtctt   1920

cggcatcccc atgatcggtc ccaccgagct cttcagttgt aacttttcca agaacgacgt   1980

catgctcagc gccgtggtca tgacctactg gacgaacttc gccaaaactg gtgatccaaa   2040

tcaaccagtt cctcaggata ccaagttcat tcacacaaaa cccaaccgct ttgaagaagt   2100

ggcctggtcc aagtataatc ccaaagacca gctctatctg catattggct tgaaacccag   2160

agtgagagat cactaccggg caacgaaagt ggctttctgg ttggaactcg ttcctcattt   2220

gcacaacttg aacgagatat tccagtatgt ttcaacaacc acaaaggttc ctccaccaga   2280

catgacatca tttccctatg gcacccggcg atctcccgcc aagatatggc caaccaccaa   2340

acgcccagca atcactcctg ccaacaatcc caaacactct aaggaccctc acaaaacagg   2400

gcctgaggac acaactgtcc tcattgaaac caaacgagat tattccaccg aattaagtgt   2460

caccattgcc gtcggggcgt cgctcctctt cctcaacatc ttagcttttg cggcgctgta   2520

ctacaaaaag gacaagaggc gccatgagac tcacaggcgc cccagtcccc agagaaacac   2580

cacaaatgat atcgctcaca tccagaacga agagatcatg tctctgcaga tgaagcagct   2640

ggaacacgat cacgagtgtg agtcgctgca ggcacacgac acactgaggc tcacctgccc   2700

gccagactac accctcacgc tgcgccggtc gccagatgac atcccactta tgacgccaaa   2760

caccatcacc atgattccaa acacactgac ggggatgcag cctttgcaca cttttaacac   2820

cttcagtgga ggacaaaaca gtacaaattt accccacgga cattccacca ctagagtata   2880

gctttgccct atttcccttc ctatccctct gccctacccg ctcagcaaca tagaagaggg   2940

aaggaaagag agaaggaaag agagagagaa agaaagtctc cagaccagga atgtttttgt   3000

cccactgact taagacaaaa atgcaaaaag gcagtcatcc catcccggca gacccttatc   3060

gttggtgttt tccagtatta caagatcaac ttctgaccct gtgaaatgtg agaagtacac   3120

atttctgtta aaataactgc tttaagatct ctaccactcc aatcgatgtt tagtgtgata   3180

ggacatcacc atttcaaggc cccgggtgtt tccaacgtca tggaagcagc tgacacttct   3240

gaaactcagc caaggacact tgatattttt taattacaat ggaagtttaa acatttcttt   3300

ctgtgccaca caatggatgg ctctccttaa gtgaagaaag agtcaatgag attttgccca   3360

gcacatggag ctgtaatcca gagagaagga aacgtagaaa tttattatta aaagaatgga   3420

ctgtgcagcg aaatctgtac ggttctgtgc aaagaggtgt tttgccagcc tgaactatat   3480

ttaagagact ttgtaaaaaa gaaaaatgta tatagctgtg agtttaaaca aaaaccacaa   3540

acagacaaac aagaaaaaaa gcttttattg gtgttttcac tttgaaagag cttttagcaa   3600

ggttgtgctt ttcattgtgc tctgtacgta tataaatata tatatatata cacacacaca   3660

cacacattag tcatatcacc tctgtttcct ccccaacaaa agaggctttt cttcttaatt   3720

acttgtggta aacaaagaca tgggattttc ttacatgaga ttctcatttg taggaggatg   3780

tgatgtccca cagaagaccc agacggtctg tgtggcctat ttcccccgtc aggttgcaca   3840

ggtgcatgca agagcattct taggagacca ctgttttgaa aaacttttga cttgtacgtg   3900

ttagccttca tgaaattgca gtacagagat gggtccccaa agtggagtgt atttacagct   3960

tgttaaatta gagacatgca cacacaaaga atcagtaggg agaaacaaaa atacaagtcc   4020

cgttctgtag ctctggccct ttgaatatgt ttaggaagag ttgcttccca tttcagggcc   4080

ctgccaaaaa aagaagaaag cttgcctttg gtggggctat gccccttgga gtaaatacgg   4140

ctctgtgttc cctagcagct gcgggagggt ttggccgatg aagtacctgc tcagcttagc   4200

taatcagatt gaaggaagac atgtgtcttt cctttttgtt taagcactcg gtcccttatt   4260

tatcagtaag caggttttta aaaatctttt atatcattta tgggatcaaa catatgattg   4320

tctgaaaaca tcactttttg tggatttgtg tatccggtca ccaaacggtg aatattatag   4380

aagaatgggg gaagaaagga tagaatatta aaactgcttt gcatgggttt tctgggaaat   4440

taggataact tcactgagaa gacattgaat ggaaattatt cacccatttt aaattggtga   4500

cctagggatc agagatttgt ctttccaaca gcttgtcatt ttttcatttc tcttctcatt   4560

tttcaggaaa gttttgagtg ttataaggtg gaaggaaaca tagtagcaat ggatactttt   4620

ttgaaaaatt attgcattac caagaaacag tagccaaaga tatttgaaga tcatgttcct   4680

cggctccatt gtgggttatt ctagaaatcc agtcttaaat ctctccgcta aagtggacat   4740

tccccataaa aattgtccag ctgcctggct cttttgcaat aacaaccttt gattactgaa   4800

tccctacact caaactatag tgatatatca gtgtttgaga gtgacctcta gaaaaaagaa   4860

aagtgttttt agaaatgcgt acaagtcacc cccaaatcct attgcttatc ttgggttaaa   4920

tttgagagtg attctctgta tataaatatg tgaaatatta ttatctcaac ttagcacacg   4980

tgaagcaaca tttctttcct acagagaggt gtcatggtaa gatttcattc cgaattcatt   5040

gtttcataga gctatgatca ggccatttct gcaagcaatg tatgacccca cctgagcaac   5100

cacaaatagg ctctctgtga aactacaaag gaagttatgt gtggcatcca tgttggtttc   5160

gtctgtctgt aatgtgaatt ccagtatttg tttagtattt ccagttgtct cctgctagca   5220

atatgtacag taacgcgtca ggcttgtgac atttgaataa ggaaaaacag agttcctgtt   5280

aagtgaataa ctttagcttt tacaggggat tatgatcaaa agtgatttta gtacatctta   5340

aatgatatct tatttctaca tggaaagaag ttatagaatc ttcatagagt tctatgagaa   5400

aaaatatact tgctatctat aaaaaagaga aaaaagaaaa aaaatgagaa aaaagtaaga   5460

aaaaaaaaaa tcctgtccta ggcttttact cttgatcttc aaaggcacgc agggtttaat   5520

ggttccttgg gttattattt tgcagttttg ttttttattt tgccttaagt aatgatagaa   5580

gatatatatg gccggacaca tatgtataaa cttttcagca gcatttttaa taataaaata   5640

tcacagtatt ttctaaaaaa aaaaaaaaaa aa                                 5672


<210>  561
<211>  816
<212>  PRT
<213>  Homo sapiens

<400>  561


Met Ser Arg Pro Gln Gly Leu Leu Trp Leu Pro Leu Leu Phe Thr Pro 
1               5                   10                  15      


Val Cys Val Met Leu Asn Ser Asn Val Leu Leu Trp Leu Thr Ala Leu 
            20                  25                  30          


Ala Ile Lys Phe Thr Leu Ile Asp Ser Gln Ala Gln Tyr Pro Val Val 
        35                  40                  45              


Asn Thr Asn Tyr Gly Lys Ile Arg Gly Leu Arg Thr Pro Leu Pro Asn 
    50                  55                  60                  


Glu Ile Leu Gly Pro Val Glu Gln Tyr Leu Gly Val Pro Tyr Ala Ser 
65                  70                  75                  80  


Pro Pro Thr Gly Glu Arg Arg Phe Gln Pro Pro Glu Pro Pro Ser Ser 
                85                  90                  95      


Trp Thr Gly Ile Arg Asn Thr Thr Gln Phe Ala Ala Val Cys Pro Gln 
            100                 105                 110         


His Leu Asp Glu Arg Ser Leu Leu His Asp Met Leu Pro Ile Trp Phe 
        115                 120                 125             


Thr Ala Asn Leu Asp Thr Leu Met Thr Tyr Val Gln Asp Gln Asn Glu 
    130                 135                 140                 


Asp Cys Leu Tyr Leu Asn Ile Tyr Val Pro Thr Glu Asp Asp Ile His 
145                 150                 155                 160 


Asp Gln Asn Ser Lys Lys Pro Val Met Val Tyr Ile His Gly Gly Ser 
                165                 170                 175     


Tyr Met Glu Gly Thr Gly Asn Met Ile Asp Gly Ser Ile Leu Ala Ser 
            180                 185                 190         


Tyr Gly Asn Val Ile Val Ile Thr Ile Asn Tyr Arg Leu Gly Ile Leu 
        195                 200                 205             


Gly Phe Leu Ser Thr Gly Asp Gln Ala Ala Lys Gly Asn Tyr Gly Leu 
    210                 215                 220                 


Leu Asp Gln Ile Gln Ala Leu Arg Trp Ile Glu Glu Asn Val Gly Ala 
225                 230                 235                 240 


Phe Gly Gly Asp Pro Lys Arg Val Thr Ile Phe Gly Ser Gly Ala Gly 
                245                 250                 255     


Ala Ser Cys Val Ser Leu Leu Thr Leu Ser His Tyr Ser Glu Gly Leu 
            260                 265                 270         


Phe Gln Lys Ala Ile Ile Gln Ser Gly Thr Ala Leu Ser Ser Trp Ala 
        275                 280                 285             


Val Asn Tyr Gln Pro Ala Lys Tyr Thr Arg Ile Leu Ala Asp Lys Val 
    290                 295                 300                 


Gly Cys Asn Met Leu Asp Thr Thr Asp Met Val Glu Cys Leu Arg Asn 
305                 310                 315                 320 


Lys Asn Tyr Lys Glu Leu Ile Gln Gln Thr Ile Thr Pro Ala Thr Tyr 
                325                 330                 335     


His Ile Ala Phe Gly Pro Val Ile Asp Gly Asp Val Ile Pro Asp Asp 
            340                 345                 350         


Pro Gln Ile Leu Met Glu Gln Gly Glu Phe Leu Asn Tyr Asp Ile Met 
        355                 360                 365             


Leu Gly Val Asn Gln Gly Glu Gly Leu Lys Phe Val Asp Gly Ile Val 
    370                 375                 380                 


Asp Asn Glu Asp Gly Val Thr Pro Asn Asp Phe Asp Phe Ser Val Ser 
385                 390                 395                 400 


Asn Phe Val Asp Asn Leu Tyr Gly Tyr Pro Glu Gly Lys Asp Thr Leu 
                405                 410                 415     


Arg Glu Thr Ile Lys Phe Met Tyr Thr Asp Trp Ala Asp Lys Glu Asn 
            420                 425                 430         


Pro Glu Thr Arg Arg Lys Thr Leu Val Ala Leu Phe Thr Asp His Gln 
        435                 440                 445             


Trp Val Ala Pro Ala Val Ala Thr Ala Asp Leu His Ala Gln Tyr Gly 
    450                 455                 460                 


Ser Pro Thr Tyr Phe Tyr Ala Phe Tyr His His Cys Gln Ser Glu Met 
465                 470                 475                 480 


Lys Pro Ser Trp Ala Asp Ser Ala His Gly Asp Glu Val Pro Tyr Val 
                485                 490                 495     


Phe Gly Ile Pro Met Ile Gly Pro Thr Glu Leu Phe Ser Cys Asn Phe 
            500                 505                 510         


Ser Lys Asn Asp Val Met Leu Ser Ala Val Val Met Thr Tyr Trp Thr 
        515                 520                 525             


Asn Phe Ala Lys Thr Gly Asp Pro Asn Gln Pro Val Pro Gln Asp Thr 
    530                 535                 540                 


Lys Phe Ile His Thr Lys Pro Asn Arg Phe Glu Glu Val Ala Trp Ser 
545                 550                 555                 560 


Lys Tyr Asn Pro Lys Asp Gln Leu Tyr Leu His Ile Gly Leu Lys Pro 
                565                 570                 575     


Arg Val Arg Asp His Tyr Arg Ala Thr Lys Val Ala Phe Trp Leu Glu 
            580                 585                 590         


Leu Val Pro His Leu His Asn Leu Asn Glu Ile Phe Gln Tyr Val Ser 
        595                 600                 605             


Thr Thr Thr Lys Val Pro Pro Pro Asp Met Thr Ser Phe Pro Tyr Gly 
    610                 615                 620                 


Thr Arg Arg Ser Pro Ala Lys Ile Trp Pro Thr Thr Lys Arg Pro Ala 
625                 630                 635                 640 


Ile Thr Pro Ala Asn Asn Pro Lys His Ser Lys Asp Pro His Lys Thr 
                645                 650                 655     


Gly Pro Glu Asp Thr Thr Val Leu Ile Glu Thr Lys Arg Asp Tyr Ser 
            660                 665                 670         


Thr Glu Leu Ser Val Thr Ile Ala Val Gly Ala Ser Leu Leu Phe Leu 
        675                 680                 685             


Asn Ile Leu Ala Phe Ala Ala Leu Tyr Tyr Lys Lys Asp Lys Arg Arg 
    690                 695                 700                 


His Glu Thr His Arg Arg Pro Ser Pro Gln Arg Asn Thr Thr Asn Asp 
705                 710                 715                 720 


Ile Ala His Ile Gln Asn Glu Glu Ile Met Ser Leu Gln Met Lys Gln 
                725                 730                 735     


Leu Glu His Asp His Glu Cys Glu Ser Leu Gln Ala His Asp Thr Leu 
            740                 745                 750         


Arg Leu Thr Cys Pro Pro Asp Tyr Thr Leu Thr Leu Arg Arg Ser Pro 
        755                 760                 765             


Asp Asp Ile Pro Leu Met Thr Pro Asn Thr Ile Thr Met Ile Pro Asn 
    770                 775                 780                 


Thr Leu Thr Gly Met Gln Pro Leu His Thr Phe Asn Thr Phe Ser Gly 
785                 790                 795                 800 


Gly Gln Asn Ser Thr Asn Leu Pro His Gly His Ser Thr Thr Arg Val 
                805                 810                 815     

<210>  562
<211>  9661
<212>  DNA
<213>  Homo sapiens

<400>  562
ccgaggccgc ctcgcccgcc gcgcgcgccg gtccggcagc gcacgggtta aggctggcac     60

cgcgcccggc gggagggggg gcgcccacct cccctcctcc ccgcgccggg catgcggggc    120

ccagtgggca ccgaggagga gctgccgcgg ctgttcgccg aggagatgga gaatgaggac    180

gagatgtcag aagaagaaga tggtggtctt gaagccttcg atgacttttt ccctgtggag    240

cccgtgagcc ttcctaagaa gaagaaaccc aagaagctca aggaaaacaa gtgtaaaggg    300

aagcggaaga agaaagaggg gagcaatgat gagctatcag agaatgaaga ggatctggaa    360

gagaagtcgg agagtgaagg cagtgactac tccccgaata aaaagaagaa gaagaaactc    420

aaggacaaga aggagaaaaa agccaagcga aaaaagaagg atgaggatga ggatgataat    480

gatgatggat gcttaaagga gcccaagtcc tcggggcagc tcatggccga gtggggcctg    540

gacgacgtgg actacctgtt ctcggaggag gattaccaca cgctgaccaa ctacaaggcc    600

ttcagccagt tcctcaggcc actcattgcc aagaagaacc cgaagatccc catgtccaaa    660

atgatgaccg tcctgggtgc caagtggcgg gagttcagcg ccaacaaccc cttcaagggc    720

agctccgcgg cagcagcggc ggcggcggtg gctgcggctg tagagacggt caccatctcc    780

cctccgctag ccgtcagccc cccgcaggtg ccccagcctg tgcctatccg caaggccaag    840

accaaggagg gcaaagggcc tggagtgagg aagaagatca aaggctccaa agatgggaag    900

aaaaagggca aagggaaaaa gacggccggg ctcaagttcc gcttcggggg gatcagcaac    960

aagaggaaga aaggctcctc gagtgaagaa gatgagaggg aggagtcgga cttcgacagc   1020

gccagcatcc acagtgcctc cgtgcgctcc gaatgctctg cagccctggg caagaagagc   1080

aagaggaggc gcaagaagaa gaggattgat gatggtgacg gctatgagac agaccaccag   1140

gattactgtg aggtgtgcca gcagggtggg gagatcatcc tgtgcgacac ctgcccgagg   1200

gcctaccatc tcgtatgcct ggacccagag ctggagaagg ctcccgaggg caagtggagc   1260

tgcccccact gtgagaagga ggggatccag tgggagccga aggacgacga cgatgaagag   1320

gaggagggcg gctgcgagga ggaggaggac gaccacatgg agttctgccg cgtgtgcaag   1380

gacgggggcg agctgctctg ctgcgacgcc tgcccctcct cctaccacct gcattgcctc   1440

aacccgccgc tgcccgagat cccaaacggt gaatggctct gcccgcgctg tacttgcccc   1500

ccactgaagg gcaaagtcca gcggattcta cactggaggt ggacggagcc ccctgccccc   1560

ttcatggtgg ggctgccggg gcctgacgtg gagcccagcc tccctccacc taagcccctg   1620

gagggcatcc ctgagagaga gttctttgtc aagtgggcag ggctgtccta ctggcattgc   1680

tcctgggtga aggagctaca gctggagctg taccacacgg tgatgtatcg caactaccaa   1740

agaaagaacg acatggatga gccgcccccc tttgactacg gctctgggga tgaagacggc   1800

aagagcgaga agaggaagaa caaggacccc ctctatgcca agatggagga gcgcttctac   1860

cgctatggca tcaagccaga gtggatgatg attcaccgaa tcctgaacca tagctttgac   1920

aagaaggggg atgtgcacta cctgatcaag tggaaagacc tgccctacga ccagtgcacc   1980

tgggagatcg atgacatcga catcccctac tacgacaacc tcaagcaggc ctactggggc   2040

cacagggagc tgatgctggg agaagacacc aggctgccca agaggctgct caagaagggc   2100

aagaagctga gggacgacaa gcaggagaag ccgccggaca cgcccattgt ggaccccacg   2160

gtcaagttcg acaagcagcc atggtacatc gactccacag gcggcacact gcacccgtac   2220

cagctggagg gcctcaactg gctgcgcttc tcttgggccc agggcactga caccatcctg   2280

gccgatgaga tgggtctggg caagacggtg cagaccatcg tgttccttta ctccctctac   2340

aaggagggcc actccaaagg gccctacctg gttagcgcgc ccctctccac catcatcaac   2400

tgggaacgcg agtttgagat gtgggcgccc gacttctacg tggtcaccta cacgggggac   2460

aaggagagcc gctcggtgat tcgggagaac gagttttcct ttgaggacaa cgccattcgg   2520

agtgggaaga aggtattccg tatgaagaaa gaagtgcaga tcaaattcca cgtgctgctc   2580

acctcctatg agctcatcac cattgaccag gccatcctgg gctccatcga gtgggcctgc   2640

ctggtggtag atgaggccca ccgcctcaag aacaaccagt ccaagttttt tagggtctta   2700

aacagctaca agattgatta caagctgctg ctgacaggga ccccccttca gaacaacctg   2760

gaggagctgt tccatctcct caacttcctg actccagaga ggttcaacaa cctggagggc   2820

ttcctggagg agtttgctga catctccaag gaagaccaga tcaagaagct gcatgacctg   2880

ctggggccgc acatgctcag gcggctcaag gctgacgtgt tcaagaacat gccggccaag   2940

accgagctca ttgtccgggt ggagctgagc cagatgcaga agaagtacta caagttcatc   3000

ctcacacgga actttgaggc actgaactcc aaggggggcg ggaaccaagt atcgctgctc   3060

aacatcatga tggacctgaa aaagtgctgc aaccacccct acctcttccc tgtggctgcc   3120

gtggaggccc ctgtcttgcc caatggctcc tacgatggaa gctccctggt caagtcttca   3180

gggaagctca tgctgctaca gaagatgctg aagaaactgc gggatgaggg gcaccgtgtg   3240

ctcatcttct cccagatgac caagatgctg gacctcctgg aggacttcct ggagtacgaa   3300

ggctacaagt atgagcggat tgatggtggc atcaccgggg gcctccggca ggaggcaatc   3360

gacagattca atgcccccgg ggcccagcag ttctgcttcc tcctctcaac ccgggcaggt   3420

ggtctgggca tcaacctggc cacggcggac actgtcatca tctacgactc ggactggaac   3480

ccgcacaatg acatccaggc cttcagccgc gcccaccgca tcggccagaa caagaaggtg   3540

atgatctacc gcttcgtgac tcgggcctcg gtggaggagc gcatcacgca ggtggccaag   3600

cgcaagatga tgctcaccca cctggtggtg cggcccggcc tcggctccaa gtcggggtcc   3660

atgaccaagc aggagctgga cgacatcctc aagttcggca cggaggaact cttcaaggac   3720

gacgtggagg gcatgatgtc tcagggccag aggccggtca cacccatccc tgatgtccag   3780

tcctccaaag gggggaactt ggccgccagt gcaaagaaga agcacggtag caccccgcca   3840

ggtgacaaca aggacgtgga ggacagcagt gtgatccact atgacgatgc ggccatctcc   3900

aagctgctgg accggaacca ggacgctaca gatgacacgg agctacagaa catgaacgag   3960

tacctgagct ccttcaaggt ggcgcagtac gtggtgcgcg aggaggacgg cgtggaggag   4020

gtggagcggg aaatcatcaa gcaggaggag aacgtggacc ccgactactg ggagaagctg   4080

ctgcggcacc actatgagca gcagcaggag gacctggccc gcaacctggg caagggcaag   4140

cgcatccgca agcaggtcaa ctacaacgat gcctcccagg aggaccagga gtggcaggat   4200

gagctctctg ataaccagtc agaatattcc attggctctg aggatgagga tgaggacttt   4260

gaagagaggc cggaagggca gagtggacga cgacaatccc ggaggcagct gaagagtgac   4320

agggacaagc ccctgccccc gcttctcgcc cgagttggtg gcaacatcga ggtgctgggc   4380

ttcaatgccc gacagcggaa ggcctttctg aacgccatca tgcgctgggg catgcccccg   4440

caggacgcct tcaactccca ctggctggtg cgggaccttc gagggaagag cgagaaggag   4500

tttagagcct atgtgtccct cttcatgcgg cacctgtgtg agccgggggc ggatggtgca   4560

gagaccttcg cagacggcgt gccccgggag ggcctctcca ggcagcacgt gctgacccgc   4620

atcggggtca tgtcactagt taggaagaag gttcaggagt ttgagcatgt caacgggaag   4680

tacagcaccc cagacttgat ccctgagggg cccgagggga agaagtcggg cgaggtgatc   4740

tcctcggacc ccaacacacc agtgcccgcc agccctgccc acctcctgcc agccccgctg   4800

ggcctgccag acaaaatgga agcccagctg ggctacatgg atgagaaaga ccccggggca   4860

cagaagccaa ggcagcccct ggaagtccag gcccttccag ccgccttgga tagagtggag   4920

agtgaggaca agcacgagag cccagccagc aaggagagag cccgagagga gcggccagag   4980

gagacggaga aggccccgcc ctccccggag cagctgccga gagaggaggt gcttcctgag   5040

aaggagaaga tcctggacaa gctggagctg agcttgatcc acagcagagg ggacagttcc   5100

gaactcaggc cagatgacac caaggctgag gagaaggagc ccattgaaac acagcaaaat   5160

ggtgacaaag aggaagatga cgaggggaag aaggaggaca agaaggggaa attcaagttc   5220

atgttcaaca tcgcggacgg gggcttcacg gagttgcaca cgctgtggca gaacgaggag   5280

cgggctgctg tatcctctgg gaaaatctac gacatctggc accggcgcca tgactactgg   5340

ctgctggcgg gcatcgtgac gcacggctac gcccgctggc aggacatcca gaatgaccca   5400

cggtacatga tcctcaacga gcccttcaag tctgaggtcc acaagggcaa ctacctggag   5460

atgaagaaca agttcctggc ccgcaggttt aagctgctgg agcaggcgtt ggtcattgag   5520

gagcagctcc ggagggccgc gtacctgaac atgacgcagg accccaacca ccccgccatg   5580

gccctcaacg cccgcctggc tgaagtggag tgcctcgccg agagccacca gcacctgtcc   5640

aaggagtccc ttgctgggaa caagcctgcc aatgccgtcc tgcacaaggt cctgaaccag   5700

ctggaggagc tgctgagcga catgaaggcc gacgtgaccc ggctgccatc catgctgtcc   5760

cgcatccccc cggtggccgc ccggctgcag atgtcggagc gcagcatcct gagccgcctg   5820

accaaccgcg ccggggaccc caccatccag cagggcgctt tcggctcctc ccagatgtac   5880

agcaacaact ttgggcccaa cttccggggc cctggaccgg gagggattgt caactacaac   5940

cagatgcccc tggggcccta tgtgaccgat atctagccgt cctcgagact tccctgtgtt   6000

gcagcgctca tttccagctg agccacgcct gccgggccac ctgcccgacc cacatgggag   6060

agaaaagctg ccaccttttt aggagccagc gccaccttgg gacaaaaagg gaaacctagt   6120

aatgccatca catggaggac gaggcccagc tcagctgggc cagagcccag aagtgccacc   6180

tcatcataat tcaagtgttc ttccacacag cgttgccccc acaaccacgc cggacgtgcc   6240

ccctcgccac cttttccaga cgacttctta gaagagattt catttatttg tacatctttt   6300

gcactttcct attgaagact tgaacacgtt tgtcttgata aaagttggat gacgtatgga   6360

agattcgaac ctgcagcact gatgtctctt taccgatggg ttccagaccc aaggtagtcc   6420

tggcactgcc ctgtggactc agcccagctg gggaggacat ggcgcccggt gccctaggag   6480

ccctcagtgt cccctacctg acctgtctgc acctgtgtga cagccccttc tgatttggcc   6540

ccctgcccgc ttggagcctc ccagcaccag acagggcagg tttggggagc cgctgtccag   6600

ccctatggtg agaccctggc tgacatttcc cctccttcct gccaaggctg gaggccgcca   6660

ggtgtttgct ctctccttgt ggggaggtgg atcctctgcc agcaggtgtc tgtccccggc   6720

ccagcgcatc ttgaaggccc tggactctgt taccagtggg gggcctgtgg ccccggctct   6780

tcacagcagg cagaagcgta tgatcccagg gagggtgggc tggggggggg gcagcacttg   6840

cctcggagcc actgctgcgt tgggtttgcc ttctgccaga ggtgtggtta agggcagtga   6900

tagctgcgcc ccagcaagga gggtcatggg ccctgagctg gcccaggaga ccctggccct   6960

gccctgtgcc ctgggatgcc taccctgccc acctccggag gtggaaccgg gctgcccctg   7020

ggggcctgga cttgtcccat tcccctgtcc ctggaaaggc cttcccgggg gctttttgcc   7080

tgaggctgca ctcttggaag gcgtggggag agttctgcct ggagggggac tggacccagt   7140

gccctctgca gacccctccc agccgcagca ccaagggctt gctgccttgt ttcctgccag   7200

gagcgccctg acatcccaaa accatcttcc cacatgtggg ttgttggaat cccacccact   7260

cccccggacc ctgcccctcc aagttgggga cggagatggg gagcaggtca ggccctccct   7320

aggcctgttt gtgtgtgatc cttctcctgg ccccaggtcg acctggaagg cgtttctgag   7380

tcttgtactg ggaccttccc agggaaggtg ccttggggtg cagaatcctg ggaatgttag   7440

gaaagggctg cgtgaaaaac ccagctgggc ctggggtgga ggtgcacacg ggctggggct   7500

cagctccttg gagagggcct gcctgggact gagggggcca gggctgggtc aggattcacc   7560

agcttgtgtt gcagacactg gagcgattgc ctggccctcc ctaagcccta tatgcctcac   7620

tcataatgag gctgtctctg aaccccggag ggcgggacct acaagtcctt cctcttggcg   7680

cattcccaca ctccagtctg gatccaggtc tgcaaggcca gcccgaccct gacactgcac   7740

gtgggcgtag tggggagcac cctggagtgg agatgattgt cagcgggctc acatgttatg   7800

gttcatccac atgcgtgttg tgtgctctgc ggtgcctcct ggcaaagggt cctggctcgg   7860

gtcagaagct cactcccgtg ccctcgtccc caaacaagca gtggcaagca ctggggttgg   7920

ccctcgttgg gagcagtgcc caccttcctt ggcccacagc agataggtcc cgagcagcag   7980

gactggaggc ctgtggcggt cagggcaggg gtctgtgtct ccaccccaag ggctgatggt   8040

ccctcccctg tgcgccttcc tctcaggcag gcttgctctg tcccttcctc tctgcttccc   8100

tcccaggcct cgccagggct cccttctcct ctgcctggtt agactcgggc acccaggaaa   8160

gcctggccag ggctcctttg ggcctgggcc ccctgcactg cctggtccag aaggggtggt   8220

gctgtccgtg gccagcaccc cggggcccgg gaggggtggg ctactagagt cagagcgggt   8280

ttggggctga ccagtttggg agaggagaaa agatctgaga atgtccttct tggtttgtca   8340

gtcatctctg ccaaaagtgg tgatggtggt gtccgtatgt ttggcgtctt tgggctgggt   8400

ttggtttttg ctgctggtag aatcagggtc ctcgggcatg aacgcgagcc caaagtgcca   8460

gtctgcgatt ggaaatttcc agccacttta agccagtgct gagtagggct tctgcagagc   8520

catgtttgag ccaaggtctt ggaaggcatt gccccatggg ctcaggtgac tcggggtgga   8580

gtgagcacgt ctgcagggcc ctctcataca cgcctgaggc agaagcagcg tcccccgtga   8640

aagccacctt ccgaagctcc tgcgtttttt gcaaacttgg cttcccccag gggcaggctg   8700

gactttccct gccccctatg attgaagtcc tcctgctttt gggggctgcc ttcccagagt   8760

cccccgggtg ctcccctgcc gaggtcagga gctgaccaag ccttggcccg gtgacacctg   8820

cagccctcac tcctgtcatc ccaggacact tgaggcccaa ggaggtggag tggagagtgg   8880

gctcgggtac atgggagcca gaagccagat ggacttggtc aagtgtcggt cacttggagc   8940

ctccagtgtg cgtcagggtc tgtgggcagg ggacagggcg tgggtggggg ccgaggctgg   9000

cacgcccctc tgccctcacc gtcttggtga cctggcctcg gcccctcccc caagtctctt   9060

ctgtgcaagg cccgcctcgg cctcggcagc tggttcctgt cctgttttct gtgtctgaaa   9120

gtttacaggt tgtggtgcat cagcccaaac tcactggcgt tgtgtttttt ttttctttaa   9180

ttttcagatt ttttttttaa acaaagtatt tttttaggtg cgataaccca gaaagggccc   9240

gttgggtgtg tgtgtgtgtc ctgaactcct caagcagcga ttggagccca agcacccctg   9300

gagaggaagg gagggtcccc actggcccgt ggggtctgag ttcaggggtg tggagggagc   9360

agactccacc ggcccaggcc cagctaagag ggggccgacc cctttcccca ggcacagccc   9420

caggctggca aagggagggc cctgggctgg gtgcaaggcg cgccaggagt cccagccagg   9480

gtggccccgg cgggggcggg tccagctttg gaagccaggc tcccctgtga gccgtggctt   9540

gtctggtctt cgcccacggg aggctggaca gaggctgtag ccaacacaat cacctttact   9600

ttgtactctg tgtgtatgtt ttggttttct gtgttttaat aaatcctttg ggaaaggatt   9660

t                                                                   9661


<210>  563
<211>  1954
<212>  PRT
<213>  Homo sapiens

<400>  563


Met Arg Gly Pro Val Gly Thr Glu Glu Glu Leu Pro Arg Leu Phe Ala 
1               5                   10                  15      


Glu Glu Met Glu Asn Glu Asp Glu Met Ser Glu Glu Glu Asp Gly Gly 
            20                  25                  30          


Leu Glu Ala Phe Asp Asp Phe Phe Pro Val Glu Pro Val Ser Leu Pro 
        35                  40                  45              


Lys Lys Lys Lys Pro Lys Lys Leu Lys Glu Asn Lys Cys Lys Gly Lys 
    50                  55                  60                  


Arg Lys Lys Lys Glu Gly Ser Asn Asp Glu Leu Ser Glu Asn Glu Glu 
65                  70                  75                  80  


Asp Leu Glu Glu Lys Ser Glu Ser Glu Gly Ser Asp Tyr Ser Pro Asn 
                85                  90                  95      


Lys Lys Lys Lys Lys Lys Leu Lys Asp Lys Lys Glu Lys Lys Ala Lys 
            100                 105                 110         


Arg Lys Lys Lys Asp Glu Asp Glu Asp Asp Asn Asp Asp Gly Cys Leu 
        115                 120                 125             


Lys Glu Pro Lys Ser Ser Gly Gln Leu Met Ala Glu Trp Gly Leu Asp 
    130                 135                 140                 


Asp Val Asp Tyr Leu Phe Ser Glu Glu Asp Tyr His Thr Leu Thr Asn 
145                 150                 155                 160 


Tyr Lys Ala Phe Ser Gln Phe Leu Arg Pro Leu Ile Ala Lys Lys Asn 
                165                 170                 175     


Pro Lys Ile Pro Met Ser Lys Met Met Thr Val Leu Gly Ala Lys Trp 
            180                 185                 190         


Arg Glu Phe Ser Ala Asn Asn Pro Phe Lys Gly Ser Ser Ala Ala Ala 
        195                 200                 205             


Ala Ala Ala Ala Val Ala Ala Ala Val Glu Thr Val Thr Ile Ser Pro 
    210                 215                 220                 


Pro Leu Ala Val Ser Pro Pro Gln Val Pro Gln Pro Val Pro Ile Arg 
225                 230                 235                 240 


Lys Ala Lys Thr Lys Glu Gly Lys Gly Pro Gly Val Arg Lys Lys Ile 
                245                 250                 255     


Lys Gly Ser Lys Asp Gly Lys Lys Lys Gly Lys Gly Lys Lys Thr Ala 
            260                 265                 270         


Gly Leu Lys Phe Arg Phe Gly Gly Ile Ser Asn Lys Arg Lys Lys Gly 
        275                 280                 285             


Ser Ser Ser Glu Glu Asp Glu Arg Glu Glu Ser Asp Phe Asp Ser Ala 
    290                 295                 300                 


Ser Ile His Ser Ala Ser Val Arg Ser Glu Cys Ser Ala Ala Leu Gly 
305                 310                 315                 320 


Lys Lys Ser Lys Arg Arg Arg Lys Lys Lys Arg Ile Asp Asp Gly Asp 
                325                 330                 335     


Gly Tyr Glu Thr Asp His Gln Asp Tyr Cys Glu Val Cys Gln Gln Gly 
            340                 345                 350         


Gly Glu Ile Ile Leu Cys Asp Thr Cys Pro Arg Ala Tyr His Leu Val 
        355                 360                 365             


Cys Leu Asp Pro Glu Leu Glu Lys Ala Pro Glu Gly Lys Trp Ser Cys 
    370                 375                 380                 


Pro His Cys Glu Lys Glu Gly Ile Gln Trp Glu Pro Lys Asp Asp Asp 
385                 390                 395                 400 


Asp Glu Glu Glu Glu Gly Gly Cys Glu Glu Glu Glu Asp Asp His Met 
                405                 410                 415     


Glu Phe Cys Arg Val Cys Lys Asp Gly Gly Glu Leu Leu Cys Cys Asp 
            420                 425                 430         


Ala Cys Pro Ser Ser Tyr His Leu His Cys Leu Asn Pro Pro Leu Pro 
        435                 440                 445             


Glu Ile Pro Asn Gly Glu Trp Leu Cys Pro Arg Cys Thr Cys Pro Pro 
    450                 455                 460                 


Leu Lys Gly Lys Val Gln Arg Ile Leu His Trp Arg Trp Thr Glu Pro 
465                 470                 475                 480 


Pro Ala Pro Phe Met Val Gly Leu Pro Gly Pro Asp Val Glu Pro Ser 
                485                 490                 495     


Leu Pro Pro Pro Lys Pro Leu Glu Gly Ile Pro Glu Arg Glu Phe Phe 
            500                 505                 510         


Val Lys Trp Ala Gly Leu Ser Tyr Trp His Cys Ser Trp Val Lys Glu 
        515                 520                 525             


Leu Gln Leu Glu Leu Tyr His Thr Val Met Tyr Arg Asn Tyr Gln Arg 
    530                 535                 540                 


Lys Asn Asp Met Asp Glu Pro Pro Pro Phe Asp Tyr Gly Ser Gly Asp 
545                 550                 555                 560 


Glu Asp Gly Lys Ser Glu Lys Arg Lys Asn Lys Asp Pro Leu Tyr Ala 
                565                 570                 575     


Lys Met Glu Glu Arg Phe Tyr Arg Tyr Gly Ile Lys Pro Glu Trp Met 
            580                 585                 590         


Met Ile His Arg Ile Leu Asn His Ser Phe Asp Lys Lys Gly Asp Val 
        595                 600                 605             


His Tyr Leu Ile Lys Trp Lys Asp Leu Pro Tyr Asp Gln Cys Thr Trp 
    610                 615                 620                 


Glu Ile Asp Asp Ile Asp Ile Pro Tyr Tyr Asp Asn Leu Lys Gln Ala 
625                 630                 635                 640 


Tyr Trp Gly His Arg Glu Leu Met Leu Gly Glu Asp Thr Arg Leu Pro 
                645                 650                 655     


Lys Arg Leu Leu Lys Lys Gly Lys Lys Leu Arg Asp Asp Lys Gln Glu 
            660                 665                 670         


Lys Pro Pro Asp Thr Pro Ile Val Asp Pro Thr Val Lys Phe Asp Lys 
        675                 680                 685             


Gln Pro Trp Tyr Ile Asp Ser Thr Gly Gly Thr Leu His Pro Tyr Gln 
    690                 695                 700                 


Leu Glu Gly Leu Asn Trp Leu Arg Phe Ser Trp Ala Gln Gly Thr Asp 
705                 710                 715                 720 


Thr Ile Leu Ala Asp Glu Met Gly Leu Gly Lys Thr Val Gln Thr Ile 
                725                 730                 735     


Val Phe Leu Tyr Ser Leu Tyr Lys Glu Gly His Ser Lys Gly Pro Tyr 
            740                 745                 750         


Leu Val Ser Ala Pro Leu Ser Thr Ile Ile Asn Trp Glu Arg Glu Phe 
        755                 760                 765             


Glu Met Trp Ala Pro Asp Phe Tyr Val Val Thr Tyr Thr Gly Asp Lys 
    770                 775                 780                 


Glu Ser Arg Ser Val Ile Arg Glu Asn Glu Phe Ser Phe Glu Asp Asn 
785                 790                 795                 800 


Ala Ile Arg Ser Gly Lys Lys Val Phe Arg Met Lys Lys Glu Val Gln 
                805                 810                 815     


Ile Lys Phe His Val Leu Leu Thr Ser Tyr Glu Leu Ile Thr Ile Asp 
            820                 825                 830         


Gln Ala Ile Leu Gly Ser Ile Glu Trp Ala Cys Leu Val Val Asp Glu 
        835                 840                 845             


Ala His Arg Leu Lys Asn Asn Gln Ser Lys Phe Phe Arg Val Leu Asn 
    850                 855                 860                 


Ser Tyr Lys Ile Asp Tyr Lys Leu Leu Leu Thr Gly Thr Pro Leu Gln 
865                 870                 875                 880 


Asn Asn Leu Glu Glu Leu Phe His Leu Leu Asn Phe Leu Thr Pro Glu 
                885                 890                 895     


Arg Phe Asn Asn Leu Glu Gly Phe Leu Glu Glu Phe Ala Asp Ile Ser 
            900                 905                 910         


Lys Glu Asp Gln Ile Lys Lys Leu His Asp Leu Leu Gly Pro His Met 
        915                 920                 925             


Leu Arg Arg Leu Lys Ala Asp Val Phe Lys Asn Met Pro Ala Lys Thr 
    930                 935                 940                 


Glu Leu Ile Val Arg Val Glu Leu Ser Gln Met Gln Lys Lys Tyr Tyr 
945                 950                 955                 960 


Lys Phe Ile Leu Thr Arg Asn Phe Glu Ala Leu Asn Ser Lys Gly Gly 
                965                 970                 975     


Gly Asn Gln Val Ser Leu Leu Asn Ile Met Met Asp Leu Lys Lys Cys 
            980                 985                 990         


Cys Asn His Pro Tyr Leu Phe Pro  Val Ala Ala Val Glu  Ala Pro Val 
        995                 1000                 1005             


Leu Pro  Asn Gly Ser Tyr Asp  Gly Ser Ser Leu Val  Lys Ser Ser 
    1010                 1015                 1020             


Gly Lys  Leu Met Leu Leu Gln  Lys Met Leu Lys Lys  Leu Arg Asp 
    1025                 1030                 1035             


Glu Gly  His Arg Val Leu Ile  Phe Ser Gln Met Thr  Lys Met Leu 
    1040                 1045                 1050             


Asp Leu  Leu Glu Asp Phe Leu  Glu Tyr Glu Gly Tyr  Lys Tyr Glu 
    1055                 1060                 1065             


Arg Ile  Asp Gly Gly Ile Thr  Gly Gly Leu Arg Gln  Glu Ala Ile 
    1070                 1075                 1080             


Asp Arg  Phe Asn Ala Pro Gly  Ala Gln Gln Phe Cys  Phe Leu Leu 
    1085                 1090                 1095             


Ser Thr  Arg Ala Gly Gly Leu  Gly Ile Asn Leu Ala  Thr Ala Asp 
    1100                 1105                 1110             


Thr Val  Ile Ile Tyr Asp Ser  Asp Trp Asn Pro His  Asn Asp Ile 
    1115                 1120                 1125             


Gln Ala  Phe Ser Arg Ala His  Arg Ile Gly Gln Asn  Lys Lys Val 
    1130                 1135                 1140             


Met Ile  Tyr Arg Phe Val Thr  Arg Ala Ser Val Glu  Glu Arg Ile 
    1145                 1150                 1155             


Thr Gln  Val Ala Lys Arg Lys  Met Met Leu Thr His  Leu Val Val 
    1160                 1165                 1170             


Arg Pro  Gly Leu Gly Ser Lys  Ser Gly Ser Met Thr  Lys Gln Glu 
    1175                 1180                 1185             


Leu Asp  Asp Ile Leu Lys Phe  Gly Thr Glu Glu Leu  Phe Lys Asp 
    1190                 1195                 1200             


Asp Val  Glu Gly Met Met Ser  Gln Gly Gln Arg Pro  Val Thr Pro 
    1205                 1210                 1215             


Ile Pro  Asp Val Gln Ser Ser  Lys Gly Gly Asn Leu  Ala Ala Ser 
    1220                 1225                 1230             


Ala Lys  Lys Lys His Gly Ser  Thr Pro Pro Gly Asp  Asn Lys Asp 
    1235                 1240                 1245             


Val Glu  Asp Ser Ser Val Ile  His Tyr Asp Asp Ala  Ala Ile Ser 
    1250                 1255                 1260             


Lys Leu  Leu Asp Arg Asn Gln  Asp Ala Thr Asp Asp  Thr Glu Leu 
    1265                 1270                 1275             


Gln Asn  Met Asn Glu Tyr Leu  Ser Ser Phe Lys Val  Ala Gln Tyr 
    1280                 1285                 1290             


Val Val  Arg Glu Glu Asp Gly  Val Glu Glu Val Glu  Arg Glu Ile 
    1295                 1300                 1305             


Ile Lys  Gln Glu Glu Asn Val  Asp Pro Asp Tyr Trp  Glu Lys Leu 
    1310                 1315                 1320             


Leu Arg  His His Tyr Glu Gln  Gln Gln Glu Asp Leu  Ala Arg Asn 
    1325                 1330                 1335             


Leu Gly  Lys Gly Lys Arg Ile  Arg Lys Gln Val Asn  Tyr Asn Asp 
    1340                 1345                 1350             


Ala Ser  Gln Glu Asp Gln Glu  Trp Gln Asp Glu Leu  Ser Asp Asn 
    1355                 1360                 1365             


Gln Ser  Glu Tyr Ser Ile Gly  Ser Glu Asp Glu Asp  Glu Asp Phe 
    1370                 1375                 1380             


Glu Glu  Arg Pro Glu Gly Gln  Ser Gly Arg Arg Gln  Ser Arg Arg 
    1385                 1390                 1395             


Gln Leu  Lys Ser Asp Arg Asp  Lys Pro Leu Pro Pro  Leu Leu Ala 
    1400                 1405                 1410             


Arg Val  Gly Gly Asn Ile Glu  Val Leu Gly Phe Asn  Ala Arg Gln 
    1415                 1420                 1425             


Arg Lys  Ala Phe Leu Asn Ala  Ile Met Arg Trp Gly  Met Pro Pro 
    1430                 1435                 1440             


Gln Asp  Ala Phe Asn Ser His  Trp Leu Val Arg Asp  Leu Arg Gly 
    1445                 1450                 1455             


Lys Ser  Glu Lys Glu Phe Arg  Ala Tyr Val Ser Leu  Phe Met Arg 
    1460                 1465                 1470             


His Leu  Cys Glu Pro Gly Ala  Asp Gly Ala Glu Thr  Phe Ala Asp 
    1475                 1480                 1485             


Gly Val  Pro Arg Glu Gly Leu  Ser Arg Gln His Val  Leu Thr Arg 
    1490                 1495                 1500             


Ile Gly  Val Met Ser Leu Val  Arg Lys Lys Val Gln  Glu Phe Glu 
    1505                 1510                 1515             


His Val  Asn Gly Lys Tyr Ser  Thr Pro Asp Leu Ile  Pro Glu Gly 
    1520                 1525                 1530             


Pro Glu  Gly Lys Lys Ser Gly  Glu Val Ile Ser Ser  Asp Pro Asn 
    1535                 1540                 1545             


Thr Pro  Val Pro Ala Ser Pro  Ala His Leu Leu Pro  Ala Pro Leu 
    1550                 1555                 1560             


Gly Leu  Pro Asp Lys Met Glu  Ala Gln Leu Gly Tyr  Met Asp Glu 
    1565                 1570                 1575             


Lys Asp  Pro Gly Ala Gln Lys  Pro Arg Gln Pro Leu  Glu Val Gln 
    1580                 1585                 1590             


Ala Leu  Pro Ala Ala Leu Asp  Arg Val Glu Ser Glu  Asp Lys His 
    1595                 1600                 1605             


Glu Ser  Pro Ala Ser Lys Glu  Arg Ala Arg Glu Glu  Arg Pro Glu 
    1610                 1615                 1620             


Glu Thr  Glu Lys Ala Pro Pro  Ser Pro Glu Gln Leu  Pro Arg Glu 
    1625                 1630                 1635             


Glu Val  Leu Pro Glu Lys Glu  Lys Ile Leu Asp Lys  Leu Glu Leu 
    1640                 1645                 1650             


Ser Leu  Ile His Ser Arg Gly  Asp Ser Ser Glu Leu  Arg Pro Asp 
    1655                 1660                 1665             


Asp Thr  Lys Ala Glu Glu Lys  Glu Pro Ile Glu Thr  Gln Gln Asn 
    1670                 1675                 1680             


Gly Asp  Lys Glu Glu Asp Asp  Glu Gly Lys Lys Glu  Asp Lys Lys 
    1685                 1690                 1695             


Gly Lys  Phe Lys Phe Met Phe  Asn Ile Ala Asp Gly  Gly Phe Thr 
    1700                 1705                 1710             


Glu Leu  His Thr Leu Trp Gln  Asn Glu Glu Arg Ala  Ala Val Ser 
    1715                 1720                 1725             


Ser Gly  Lys Ile Tyr Asp Ile  Trp His Arg Arg His  Asp Tyr Trp 
    1730                 1735                 1740             


Leu Leu  Ala Gly Ile Val Thr  His Gly Tyr Ala Arg  Trp Gln Asp 
    1745                 1750                 1755             


Ile Gln  Asn Asp Pro Arg Tyr  Met Ile Leu Asn Glu  Pro Phe Lys 
    1760                 1765                 1770             


Ser Glu  Val His Lys Gly Asn  Tyr Leu Glu Met Lys  Asn Lys Phe 
    1775                 1780                 1785             


Leu Ala  Arg Arg Phe Lys Leu  Leu Glu Gln Ala Leu  Val Ile Glu 
    1790                 1795                 1800             


Glu Gln  Leu Arg Arg Ala Ala  Tyr Leu Asn Met Thr  Gln Asp Pro 
    1805                 1810                 1815             


Asn His  Pro Ala Met Ala Leu  Asn Ala Arg Leu Ala  Glu Val Glu 
    1820                 1825                 1830             


Cys Leu  Ala Glu Ser His Gln  His Leu Ser Lys Glu  Ser Leu Ala 
    1835                 1840                 1845             


Gly Asn  Lys Pro Ala Asn Ala  Val Leu His Lys Val  Leu Asn Gln 
    1850                 1855                 1860             


Leu Glu  Glu Leu Leu Ser Asp  Met Lys Ala Asp Val  Thr Arg Leu 
    1865                 1870                 1875             


Pro Ser  Met Leu Ser Arg Ile  Pro Pro Val Ala Ala  Arg Leu Gln 
    1880                 1885                 1890             


Met Ser  Glu Arg Ser Ile Leu  Ser Arg Leu Thr Asn  Arg Ala Gly 
    1895                 1900                 1905             


Asp Pro  Thr Ile Gln Gln Gly  Ala Phe Gly Ser Ser  Gln Met Tyr 
    1910                 1915                 1920             


Ser Asn  Asn Phe Gly Pro Asn  Phe Arg Gly Pro Gly  Pro Gly Gly 
    1925                 1930                 1935             


Ile Val  Asn Tyr Asn Gln Met  Pro Leu Gly Pro Tyr  Val Thr Asp 
    1940                 1945                 1950             


Ile 
    

<210>  564
<211>  8219
<212>  DNA
<213>  Homo sapiens

<400>  564
ccgaggccgc ctcgcccgcc gcgcgcgccg gtccggcagc gcacgggtta aggctggcac     60

cgcgcccggc gggagggggg gcgcccacct cccctcctcc ccgcgccggg catgcggggc    120

ccagtgggca ccgaggagga gctgccgcgg ctgttcgccg aggagatgga gaatgaggac    180

gagatgtcag aagaagaaga tggtggtctt gaagccttcg atgacttttt ccctgtggag    240

cccgtgagcc ttcctaagaa gaagaaaccc aagaagctca aggaaaacaa gtgtaaaggg    300

aagcggaaga agaaagaggg gagcaatgat gagctatcag agaatgaaga ggatctggaa    360

gagaagtcgg agagtgaagg cagtgactac tcccctaatg atgatggatg cttaaaggag    420

cccaagtcct cggggcagct catggccgag tggggcctgg acgacgtgga ctacctgttc    480

tcggaggagg attaccacac gctgaccaac tacaaggcct tcagccagtt cctcaggcca    540

ctcattgcca agaagaaccc gaagatcccc atgtccaaaa tgatgaccgt cctgggtgcc    600

aagtggcggg agttcagcgc caacaacccc ttcaagggca gctccgcggc agcagcggcg    660

gcggcggtgg ctgcggctgt agagacggtc accatctccc ctccgctagc cgtcagcccc    720

ccgcaggtgc cccagcctgt gcctatccgc aaggccaaga ccaaggaggg caaagggcct    780

ggagtgagga agaagatcaa aggctccaaa gatgggaaga aaaagggcaa agggaaaaag    840

acggccgggc tcaagttccg cttcgggggg atcagcaaca agaggaagaa aggctcctcg    900

agtgaagaag atgagaggga ggagtcggac ttcgacagcg ccagcatcca cagtgcctcc    960

gtgcgctccg aatgctctgc agccctgggc aagaagagca agaggaggcg caagaagaag   1020

aggattgatg atggtgacgg ctatgagaca gaccaccagg attactgtga ggtgtgccag   1080

cagggtgggg agatcatcct gtgcgacacc tgcccgaggg cctaccatct cgtatgcctg   1140

gacccagagc tggagaaggc tcccgagggc aagtggagct gcccccactg tgccacatgg   1200

agttctgccg cgtgtgcaag gacgggggcg agctgctctg ctgcgacgcc tgcccctcct   1260

cctaccacct gcattgcctc aacccgccgc tgcccgagat cccaaacggt gaatggctct   1320

gcccgcgctg tacttgcccc ccactgaagg gcaaagtcca gcggattcta cactggaggt   1380

ggacggagcc ccctgccccc ttcatggtgg ggctgccggg gcctgacgtg gagcccagcc   1440

tccctccacc taagcccctg gagggcatcc ctgagagaga gttctttgtc aagtgggcag   1500

ggctgtccta ctggcattgc tcctgggtga aggagctaca gctggagctg taccacacgg   1560

tgatgtatcg caactaccaa agaaagaacg acatggatga gccgcccccc tttgactacg   1620

gctctgggga tgaagacggc aagagcgaga agaggaagaa caaggacccc ctctatgcca   1680

agatggagga gcgcttctac cgctatggca tcaagccaga gtggatgatg attcaccgaa   1740

tcctgaacca tagctttgac aagaaggggg atgtgcacta cctgatcaag tggaaagacc   1800

tgccctacga ccagtgcacc tgggagatcg atgacatcga catcccctac tacgacaacc   1860

tcaagcaggc ctactggggc cacagggagc tgatgctggg agaagacacc aggctgccca   1920

agaggctgct caagaagggc aagaagctga gggacgacaa gcaggagaag ccgccggaca   1980

cgcccattgt ggaccccacg gtcaagttcg acaagcagcc atggtacatc gactccacag   2040

gcggcacact gcacccgtac cagctggagg gcctcaactg gctgcgcttc tcttgggccc   2100

agggcactga caccatcctg gccgatgaga tgggtctggg caagacggtg cagaccatcg   2160

tgttccttta ctccctctac aaggagggcc actccaaagg gccctacctg gttagcgcgc   2220

ccctctccac catcatcaac tgggaacgcg agtttgagat gtgggcgccc gacttctacg   2280

tggtcaccta cacgggggac aaggagagcc gctcggtgat tcgggagaac gagttttcct   2340

ttgaggacaa cgccattcgg agtgggaaga aggtattccg tatgaagaaa gaagtgcaga   2400

tcaaattcca cgtgctgctc acctcctatg agctcatcac cattgaccag gccatcctgg   2460

gctccatcga gtgggcctgc ctggtggtag atgaggccca ccgcctcaag aacaaccagt   2520

ccaagttttt tagggtctta aacagctaca agattgatta caagctgctg ctgacaggga   2580

ccccccttca gaacaacctg gaggagctgt tccatctcct caacttcctg actccagaga   2640

ggttcaacaa cctggagggc ttcctggagg agtttgctga catctccaag gaagaccaga   2700

tcaagaagct gcatgacctg ctggggccgc acatgctcag gcggctcaag gctgacgtgt   2760

tcaagaacat gccggccaag accgagctca ttgtccgggt ggagctgagc cagatgcaga   2820

agaagtacta caagttcatc ctcacacgga actttgaggc actgaactcc aaggggggcg   2880

ggaaccaagt atcgctgctc aacatcatga tggacctgaa aaagtgctgc aaccacccct   2940

acctcttccc tgtggctgcc gtggaggccc ctgtcttgcc caatggctcc tacgatggaa   3000

gctccctggt caagtcttca gggaagctca tgctgctaca gaagatgctg aagaaactgc   3060

gggatgaggg gcaccgtgtg ctcatcttct cccagatgac caagatgctg gacctcctgg   3120

aggacttcct ggagtacgaa ggctacaagt atgagcggat tgatggtggc atcaccgggg   3180

gcctccggca ggaggcaatc gacagattca atgcccccgg ggcccagcag ttctgcttcc   3240

tcctctcaac ccgggcaggt ggtctgggca tcaacctggc cacggcggac actgtcatca   3300

tctacgactc ggactggaac ccgcacaatg acatccaggc cttcagccgc gcccaccgca   3360

tcggccagaa aaaatggaag cccagctggg ctacatggat gagaaagacc ccggggcaca   3420

gaagccaagg cagcccctgg aagtccaggc ccttccagcc gccttggata gagtggagag   3480

tgaggacaag cacgagagcc cagccagcaa ggagagagcc cgagaggagc ggccagagga   3540

gacggagaag gccccgccct ccccggagca gctgccgaga gaggaggtgc ttcctgagaa   3600

ggagaagatc ctggacaagc tggagctgag cttgatccac agcagagggg acagttccga   3660

actcaggcca gatgacacca aggctgagga gaaggagccc attgaaacac agcaaaatgg   3720

tgacaaagag gaagatgacg aggggaagaa ggaggacaag aaggggaaat tcaagttcat   3780

gttcaacatc gcggacgggg gcttcacgga gttgcacacg ctgtggcaga acgaggagcg   3840

ggctgctgta tcctctggga aaatctacga catctggcac cggcgccatg actactggct   3900

gctggcgggc atcgtgacgc acggctacgc ccgctggcag gacatccaga atgacccacg   3960

gtacatgatc ctcaacgagc ccttcaagtc tgaggtccac aagggcaact acctggagat   4020

gaagaacaag ttcctggccc gcaggtttaa gctgctggag caggcgttgg tcattgagga   4080

gcagctccgg agggccgcgt acctgaacat gacgcaggac cccaaccacc ccgccatggc   4140

cctcaacgcc cgcctggctg aagtggagtg cctcgccgag agccaccagc acctgtccaa   4200

ggagtccctt gctgggaaca agcctgccaa tgccgtcctg cacaaggtcc tgaaccagct   4260

ggaggagctg ctgagcgaca tgaaggccga cgtgacccgg ctgccatcca tgctgtcccg   4320

catccccccg gtggccgccc ggctgcagat gtcggagcgc agcatcctga gccgcctgac   4380

caaccgcgcc ggggacccca ccatccagca gggcgctttc ggctcctccc agatgtacag   4440

caacaacttt gggcccaact tccggggccc tggaccggga gggattgtca actacaacca   4500

gatgcccctg gggccctatg tgaccgatat ctagccgtcc tcgagacttc cctgtgttgc   4560

agcgctcatt tccagctgag ccacgcctgc cgggccacct gcccgaccca catgggagag   4620

aaaagctgcc acctttttag gagccagcgc caccttggga caaaaaggga aacctagtaa   4680

tgccatcaca tggaggacga ggcccagctc agctgggcca gagcccagaa gtgccacctc   4740

atcataattc aagtgttctt ccacacagcg ttgcccccac aaccacgccg gacgtgcccc   4800

ctcgccacct tttccagacg acttcttaga agagatttca tttatttgta catcttttgc   4860

actttcctat tgaagacttg aacacgtttg tcttgataaa agttggatga cgtatggaag   4920

attcgaacct gcagcactga tgtctcttta ccgatgggtt ccagacccaa ggtagtcctg   4980

gcactgccct gtggactcag cccagctggg gaggacatgg cgcccggtgc cctaggagcc   5040

ctcagtgtcc cctacctgac ctgtctgcac ctgtgtgaca gccccttctg atttggcccc   5100

ctgcccgctt ggagcctccc agcaccagac agggcaggtt tggggagccg ctgtccagcc   5160

ctatggtgag accctggctg acatttcccc tccttcctgc caaggctgga ggccgccagg   5220

tgtttgctct ctccttgtgg ggaggtggat cctctgccag caggtgtctg tccccggccc   5280

agcgcatctt gaaggccctg gactctgtta ccagtggggg gcctgtggcc ccggctcttc   5340

acagcaggca gaagcgtatg atcccaggga gggtgggctg gggggggggc agcacttgcc   5400

tcggagccac tgctgcgttg ggtttgcctt ctgccagagg tgtggttaag ggcagtgata   5460

gctgcgcccc agcaaggagg gtcatgggcc ctgagctggc ccaggagacc ctggccctgc   5520

cctgtgccct gggatgccta ccctgcccac ctccggaggt ggaaccgggc tgcccctggg   5580

ggcctggact tgtcccattc ccctgtccct ggaaaggcct tcccgggggc tttttgcctg   5640

aggctgcact cttggaaggc gtggggagag ttctgcctgg agggggactg gacccagtgc   5700

cctctgcaga cccctcccag ccgcagcacc aagggcttgc tgccttgttt cctgccagga   5760

gcgccctgac atcccaaaac catcttccca catgtgggtt gttggaatcc cacccactcc   5820

cccggaccct gcccctccaa gttggggacg gagatgggga gcaggtcagg ccctccctag   5880

gcctgtttgt gtgtgatcct tctcctggcc ccaggtcgac ctggaaggcg tttctgagtc   5940

ttgtactggg accttcccag ggaaggtgcc ttggggtgca gaatcctggg aatgttagga   6000

aagggctgcg tgaaaaaccc agctgggcct ggggtggagg tgcacacggg ctggggctca   6060

gctccttgga gagggcctgc ctgggactga gggggccagg gctgggtcag gattcaccag   6120

cttgtgttgc agacactgga gcgattgcct ggccctccct aagccctata tgcctcactc   6180

ataatgaggc tgtctctgaa ccccggaggg cgggacctac aagtccttcc tcttggcgca   6240

ttcccacact ccagtctgga tccaggtctg caaggccagc ccgaccctga cactgcacgt   6300

gggcgtagtg gggagcaccc tggagtggag atgattgtca gcgggctcac atgttatggt   6360

tcatccacat gcgtgttgtg tgctctgcgg tgcctcctgg caaagggtcc tggctcgggt   6420

cagaagctca ctcccgtgcc ctcgtcccca aacaagcagt ggcaagcact ggggttggcc   6480

ctcgttggga gcagtgccca ccttccttgg cccacagcag ataggtcccg agcagcagga   6540

ctggaggcct gtggcggtca gggcaggggt ctgtgtctcc accccaaggg ctgatggtcc   6600

ctcccctgtg cgccttcctc tcaggcaggc ttgctctgtc ccttcctctc tgcttccctc   6660

ccaggcctcg ccagggctcc cttctcctct gcctggttag actcgggcac ccaggaaagc   6720

ctggccaggg ctcctttggg cctgggcccc ctgcactgcc tggtccagaa ggggtggtgc   6780

tgtccgtggc cagcaccccg gggcccggga ggggtgggct actagagtca gagcgggttt   6840

ggggctgacc agtttgggag aggagaaaag atctgagaat gtccttcttg gtttgtcagt   6900

catctctgcc aaaagtggtg atggtggtgt ccgtatgttt ggcgtctttg ggctgggttt   6960

ggtttttgct gctggtagaa tcagggtcct cgggcatgaa cgcgagccca aagtgccagt   7020

ctgcgattgg aaatttccag ccactttaag ccagtgctga gtagggcttc tgcagagcca   7080

tgtttgagcc aaggtcttgg aaggcattgc cccatgggct caggtgactc ggggtggagt   7140

gagcacgtct gcagggccct ctcatacacg cctgaggcag aagcagcgtc ccccgtgaaa   7200

gccaccttcc gaagctcctg cgttttttgc aaacttggct tcccccaggg gcaggctgga   7260

ctttccctgc cccctatgat tgaagtcctc ctgcttttgg gggctgcctt cccagagtcc   7320

cccgggtgct cccctgccga ggtcaggagc tgaccaagcc ttggcccggt gacacctgca   7380

gccctcactc ctgtcatccc aggacacttg aggcccaagg aggtggagtg gagagtgggc   7440

tcgggtacat gggagccaga agccagatgg acttggtcaa gtgtcggtca cttggagcct   7500

ccagtgtgcg tcagggtctg tgggcagggg acagggcgtg ggtgggggcc gaggctggca   7560

cgcccctctg ccctcaccgt cttggtgacc tggcctcggc ccctccccca agtctcttct   7620

gtgcaaggcc cgcctcggcc tcggcagctg gttcctgtcc tgttttctgt gtctgaaagt   7680

ttacaggttg tggtgcatca gcccaaactc actggcgttg tgtttttttt ttctttaatt   7740

ttcagatttt ttttttaaac aaagtatttt tttaggtgcg ataacccaga aagggcccgt   7800

tgggtgtgtg tgtgtgtcct gaactcctca agcagcgatt ggagcccaag cacccctgga   7860

gaggaaggga gggtccccac tggcccgtgg ggtctgagtt caggggtgtg gagggagcag   7920

actccaccgg cccaggccca gctaagaggg ggccgacccc tttccccagg cacagcccca   7980

ggctggcaaa gggagggccc tgggctgggt gcaaggcgcg ccaggagtcc cagccagggt   8040

ggccccggcg ggggcgggtc cagctttgga agccaggctc ccctgtgagc cgtggcttgt   8100

ctggtcttcg cccacgggag gctggacaga ggctgtagcc aacacaatca cctttacttt   8160

gtactctgtg tgtatgtttt ggttttctgt gttttaataa atcctttggg aaaggattt    8219


<210>  565
<211>  831
<212>  PRT
<213>  Homo sapiens

<400>  565


Met Pro Gly Pro Arg Ala Gly Glu Gly Ser Arg Gly Gln Val Glu Leu 
1               5                   10                  15      


Pro Pro Leu Cys His Met Glu Phe Cys Arg Val Cys Lys Asp Gly Gly 
            20                  25                  30          


Glu Leu Leu Cys Cys Asp Ala Cys Pro Ser Ser Tyr His Leu His Cys 
        35                  40                  45              


Leu Asn Pro Pro Leu Pro Glu Ile Pro Asn Gly Glu Trp Leu Cys Pro 
    50                  55                  60                  


Arg Cys Thr Cys Pro Pro Leu Lys Gly Lys Val Gln Arg Ile Leu His 
65                  70                  75                  80  


Trp Arg Trp Thr Glu Pro Pro Ala Pro Phe Met Val Gly Leu Pro Gly 
                85                  90                  95      


Pro Asp Val Glu Pro Ser Leu Pro Pro Pro Lys Pro Leu Glu Gly Ile 
            100                 105                 110         


Pro Glu Arg Glu Phe Phe Val Lys Trp Ala Gly Leu Ser Tyr Trp His 
        115                 120                 125             


Cys Ser Trp Val Lys Glu Leu Gln Leu Glu Leu Tyr His Thr Val Met 
    130                 135                 140                 


Tyr Arg Asn Tyr Gln Arg Lys Asn Asp Met Asp Glu Pro Pro Pro Phe 
145                 150                 155                 160 


Asp Tyr Gly Ser Gly Asp Glu Asp Gly Lys Ser Glu Lys Arg Lys Asn 
                165                 170                 175     


Lys Asp Pro Leu Tyr Ala Lys Met Glu Glu Arg Phe Tyr Arg Tyr Gly 
            180                 185                 190         


Ile Lys Pro Glu Trp Met Met Ile His Arg Ile Leu Asn His Ser Phe 
        195                 200                 205             


Asp Lys Lys Gly Asp Val His Tyr Leu Ile Lys Trp Lys Asp Leu Pro 
    210                 215                 220                 


Tyr Asp Gln Cys Thr Trp Glu Ile Asp Asp Ile Asp Ile Pro Tyr Tyr 
225                 230                 235                 240 


Asp Asn Leu Lys Gln Ala Tyr Trp Gly His Arg Glu Leu Met Leu Gly 
                245                 250                 255     


Glu Asp Thr Arg Leu Pro Lys Arg Leu Leu Lys Lys Gly Lys Lys Leu 
            260                 265                 270         


Arg Asp Asp Lys Gln Glu Lys Pro Pro Asp Thr Pro Ile Val Asp Pro 
        275                 280                 285             


Thr Val Lys Phe Asp Lys Gln Pro Trp Tyr Ile Asp Ser Thr Gly Gly 
    290                 295                 300                 


Thr Leu His Pro Tyr Gln Leu Glu Gly Leu Asn Trp Leu Arg Phe Ser 
305                 310                 315                 320 


Trp Ala Gln Gly Thr Asp Thr Ile Leu Ala Asp Glu Met Gly Leu Gly 
                325                 330                 335     


Lys Thr Val Gln Thr Ile Val Phe Leu Tyr Ser Leu Tyr Lys Glu Gly 
            340                 345                 350         


His Ser Lys Gly Pro Tyr Leu Val Ser Ala Pro Leu Ser Thr Ile Ile 
        355                 360                 365             


Asn Trp Glu Arg Glu Phe Glu Met Trp Ala Pro Asp Phe Tyr Val Val 
    370                 375                 380                 


Thr Tyr Thr Gly Asp Lys Glu Ser Arg Ser Val Ile Arg Glu Asn Glu 
385                 390                 395                 400 


Phe Ser Phe Glu Asp Asn Ala Ile Arg Ser Gly Lys Lys Val Phe Arg 
                405                 410                 415     


Met Lys Lys Glu Val Gln Ile Lys Phe His Val Leu Leu Thr Ser Tyr 
            420                 425                 430         


Glu Leu Ile Thr Ile Asp Gln Ala Ile Leu Gly Ser Ile Glu Trp Ala 
        435                 440                 445             


Cys Leu Val Val Asp Glu Ala His Arg Leu Lys Asn Asn Gln Ser Lys 
    450                 455                 460                 


Phe Phe Arg Val Leu Asn Ser Tyr Lys Ile Asp Tyr Lys Leu Leu Leu 
465                 470                 475                 480 


Thr Gly Thr Pro Leu Gln Asn Asn Leu Glu Glu Leu Phe His Leu Leu 
                485                 490                 495     


Asn Phe Leu Thr Pro Glu Arg Phe Asn Asn Leu Glu Gly Phe Leu Glu 
            500                 505                 510         


Glu Phe Ala Asp Ile Ser Lys Glu Asp Gln Ile Lys Lys Leu His Asp 
        515                 520                 525             


Leu Leu Gly Pro His Met Leu Arg Arg Leu Lys Ala Asp Val Phe Lys 
    530                 535                 540                 


Asn Met Pro Ala Lys Thr Glu Leu Ile Val Arg Val Glu Leu Ser Gln 
545                 550                 555                 560 


Met Gln Lys Lys Tyr Tyr Lys Phe Ile Leu Thr Arg Asn Phe Glu Ala 
                565                 570                 575     


Leu Asn Ser Lys Gly Gly Gly Asn Gln Val Ser Leu Leu Asn Ile Met 
            580                 585                 590         


Met Asp Leu Lys Lys Cys Cys Asn His Pro Tyr Leu Phe Pro Val Ala 
        595                 600                 605             


Ala Val Glu Ala Pro Val Leu Pro Asn Gly Ser Tyr Asp Gly Ser Ser 
    610                 615                 620                 


Leu Val Lys Ser Ser Gly Lys Leu Met Leu Leu Gln Lys Met Leu Lys 
625                 630                 635                 640 


Lys Leu Arg Asp Glu Gly His Arg Val Leu Ile Phe Ser Gln Met Thr 
                645                 650                 655     


Lys Met Leu Asp Leu Leu Glu Asp Phe Leu Glu Tyr Glu Gly Tyr Lys 
            660                 665                 670         


Tyr Glu Arg Ile Asp Gly Gly Ile Thr Gly Gly Leu Arg Gln Glu Ala 
        675                 680                 685             


Ile Asp Arg Phe Asn Ala Pro Gly Ala Gln Gln Phe Cys Phe Leu Leu 
    690                 695                 700                 


Ser Thr Arg Ala Gly Gly Leu Gly Ile Asn Leu Ala Thr Ala Asp Thr 
705                 710                 715                 720 


Val Ile Ile Tyr Asp Ser Asp Trp Asn Pro His Asn Asp Ile Gln Ala 
                725                 730                 735     


Phe Ser Arg Ala His Arg Ile Gly Gln Lys Lys Trp Lys Pro Ser Trp 
            740                 745                 750         


Ala Thr Trp Met Arg Lys Thr Pro Gly His Arg Ser Gln Gly Ser Pro 
        755                 760                 765             


Trp Lys Ser Arg Pro Phe Gln Pro Pro Trp Ile Glu Trp Arg Val Arg 
    770                 775                 780                 


Thr Ser Thr Arg Ala Gln Pro Ala Arg Arg Glu Pro Glu Arg Ser Gly 
785                 790                 795                 800 


Gln Arg Arg Arg Arg Arg Pro Arg Pro Pro Arg Ser Ser Cys Arg Glu 
                805                 810                 815     


Arg Arg Cys Phe Leu Arg Arg Arg Arg Ser Trp Thr Ser Trp Ser 
            820                 825                 830     

<210>  566
<211>  537
<212>  DNA
<213>  Homo sapiens

<400>  566
attcatccct gccacagagg ctgcaaagga tgtgggaggc tggctcattg ctcctctgtt     60

agctggcctc cgtgtccctc tccagctctg ccacatcccc ctctcattcg ctgtgtggcc    120

ccaggcaagc cgctgcacct ccctggagct tctgccctcg tctcctcctc ctggctgggc    180

ccagcatccg aggggaccct gggtgtgaat ggctctgcat cctgggaggt gcccttcatc    240

aaacctgtgc tgtggccact gctctgagcg acccacatct gttcaccgtg ttgcagcttt    300

gacaagaagg gggatgtgca ctacctgatc aagtggaaag acctgcccta cgaccagtgc    360

acctgggaga tcgatgacat cgacatcccc tactacgaca acctcaagca ggcctactgg    420

ggccacaggg agctgatgct gggagaagac accaggctgc ccaagaggct gctcaagaag    480

ggcaagaagc tgagggacga caagcaggag aagccgccgg acacgcccat tgtggac       537


<210>  567
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  567


Met Ala Leu His Pro Gly Arg Cys Pro Ser Ser Asn Leu Cys Cys Gly 
1               5                   10                  15      


His Cys Ser Glu Arg Pro Thr Ser Val His Arg Val Ala Ala Leu Thr 
            20                  25                  30          


Arg Arg Gly Met Cys Thr Thr 
        35                  

<210>  568
<211>  968
<212>  DNA
<213>  Homo sapiens

<400>  568
aatcccggcg ggaaccccgg ctgcggaagg cggctgcggc cggcgggagc cgaggggaag     60

aatggagcgc tgaggaagcg aggcgccagc cccagccgct tcgctgccgc ggagcctgca    120

cgaccgagag gtcgcggaga gaagccagag acaggccagc gacctggcga gtacccagct    180

cccttcttca tgtcttacct gtccttatta tcacagtgaa taatgcctaa tctattagtg    240

aataatgcct aatctattaa gagctatgtg aaaaacctaa actctttcca tttgcaaccc    300

ttttggtatg gtcaagtcag tggatctggc tatcatacaa actcaaatca actactacaa    360

attcagattg gctaagcaga ttccagccat tttaaaagct tgtctctgct ctatcctgta    420

tctttctgca tttacatgta acttcactgt gggtgtcctt acagtatata tttttatgag    480

acatcaaact tactaagagt actttatagc atagtattta ggaacttagg ggtcagaatt    540

aagacattgt tagatgttag cttctgttac tactctgatt ctagcctccc taattctcat    600

tcttttttgg gggttgcagg ggagttcact gtgctgtttg ctatatttca agcctcaaaa    660

gacaatgaag ttcccaaatg ctcttcaagg cagaacaaat ataaataatg attctcacac    720

caaatgtgtg caaagttcaa atattgcatt aatggtgctt tttattgtgc aaatcatacg    780

actaacccat catgtccttt ctgtgtcagg aagaacatgg atgggaatag aaggatcttt    840

gaaatcctac cctctgtgta aatcagtatc tgtgaatttt tctcttgtta gtactgattt    900

atttactctt tctggtgtat ctgctctttc ccttaaaacc tttatgataa aaacatattt    960

gaatgccc                                                             968


<210>  569
<211>  137
<212>  PRT
<213>  Homo sapiens

<400>  569


Met Leu Ala Ser Val Thr Thr Leu Ile Leu Ala Ser Leu Ile Leu Ile 
1               5                   10                  15      


Leu Phe Trp Gly Leu Gln Gly Ser Ser Leu Cys Cys Leu Leu Tyr Phe 
            20                  25                  30          


Lys Pro Gln Lys Thr Met Lys Phe Pro Asn Ala Leu Gln Gly Arg Thr 
        35                  40                  45              


Asn Ile Asn Asn Asp Ser His Thr Lys Cys Val Gln Ser Ser Asn Ile 
    50                  55                  60                  


Ala Leu Met Val Leu Phe Ile Val Gln Ile Ile Arg Leu Thr His His 
65                  70                  75                  80  


Val Leu Ser Val Ser Gly Arg Thr Trp Met Gly Ile Glu Gly Ser Leu 
                85                  90                  95      


Lys Ser Tyr Pro Leu Cys Lys Ser Val Ser Val Asn Phe Ser Leu Val 
            100                 105                 110         


Ser Thr Asp Leu Phe Thr Leu Ser Gly Val Ser Ala Leu Ser Leu Lys 
        115                 120                 125             


Thr Phe Met Ile Lys Thr Tyr Leu Asn 
    130                 135         

<210>  570
<211>  1904
<212>  DNA
<213>  Homo sapiens

<400>  570
aaatgctcgg tgctttaaat ttgcaattac catatttgca gaaacttgaa aaatcatccc     60

aattaaatga caaaatgtat aggaggatta tctttctttt gcccttacaa ctcaaattat    120

attcgaagta acatttttac agcagtcaaa acttttaacc aaaaattcac acctgcagtc    180

tcataagttt aacaaaatgg ccacattcca cgctttattt tcttaacaac cctgactgtt    240

taaatgactc ccattgaacc aacagcttac agttgctggg caataaaaaa gcgagcaaaa    300

ggacctccag ccctgctgtt ttagctatta cccagcactc tcagagtttg ctctagtctg    360

gctgttcaat caaattcatt ttccagtagc ttctggcctt tgtctcctct ttctggccac    420

gcatttcatt gcctcctgaa tttgatgaca acattttctt tcttcacttt gaatcttggc    480

ccagaatctc actctcccag ccccatggaa agatggggaa aagatttcat tctgctgatc    540

aaatttgtta gaagacattc tttagagtct gaaaaaatat atttcattag cagttctcta    600

ggtagtggaa tttttagtga tgtttactct tttttccttg ttctaatttt cctctaataa    660

acagaaaaaa agcaagagta acccaccaaa tttggataaa gggcttctgc ttttcatatt    720

ctcttaacca gaacagctta acttttctcc atttatttat ttaagtattt attcatattt    780

gaaagatttt tattatccac aacactcata tctctttttg atcctactgt aatatcacat    840

tatcctacct aaagatgaat tgttccaacc ctgatgcttt ggtaatcatc ttttctaaat    900

taaaaattga gagagagaga gatttgtaat ctagcaaaat atgttattta cttaagaatg    960

acctttgtta tggaaaaaca aagaaagaaa gaaatcaggt cttttttgga aaatctggga   1020

cattgaattg ttacacgtaa catgtgtccc cctagggaca taggtcactt tcagtatttg   1080

ccaaagcatt aggtcagcca gacatgtgaa acatctcgga gcttaataac tgagctgctt   1140

caatgtgttt tgataaaagt ttaaattctc tggccccaat ttattgaaca catgcctttg   1200

acaatacagc atttctttct taggctatta gtgaaagatt aaccatctac tcagtgattg   1260

ttattgtgcc tgtatgtgtg cagtatgaac agttatgtaa caaaactgca aagattagag   1320

acctttaaaa ggatctgggg aaataggaag agtctataat cttataggaa aggaatgaat   1380

tatgcaagca actaaaagtg tgtcaatatt ctctgcttca caaacaaatt ggaaaccagt   1440

ggtaaacttt agatcagaaa cagaaactca aaaaatgaaa gaactggcca tgagcagtgg   1500

ctcaggcctg taatcccagc actttgggag gtcgaggcag gcggatcacc tgaggtcggg   1560

agtttgagac cagcctgacc aacatggaga aaccctatct ttactaaaaa tacaaaaaat   1620

tagacaggca tgatggcaga tgcctgtaat cccagctact tgggaggctg aggcaggaga   1680

atcacatgaa cccaggaggt ggaggttgtg gtgagcctat attgcgccat tgcacttcag   1740

cctgggcaac aagagcaaaa ctctgtctca aaaaaagaaa aaagaaaaag aaaagaagaa   1800

aaagaaagaa cctagaaact tagaggccaa ctaaggagac aggcattttt ataaaaagag   1860

ttgaaagaaa tttgtggtag aataacagaa aatacagaca agtt                    1904


<210>  571
<211>  70
<212>  PRT
<213>  Homo sapiens

<400>  571


Met Thr Thr Phe Ser Phe Phe Thr Leu Asn Leu Gly Pro Glu Ser His 
1               5                   10                  15      


Ser Pro Ser Pro Met Glu Arg Trp Gly Lys Asp Phe Ile Leu Leu Ile 
            20                  25                  30          


Lys Phe Val Arg Arg His Ser Leu Glu Ser Glu Lys Ile Tyr Phe Ile 
        35                  40                  45              


Ser Ser Ser Leu Gly Ser Gly Ile Phe Ser Asp Val Tyr Ser Phe Phe 
    50                  55                  60                  


Leu Val Leu Ile Phe Leu 
65                  70  

<210>  572
<211>  2528
<212>  DNA
<213>  Homo sapiens

<400>  572
agagtaaatc agtaaggctc cacccatttc acaggaggcc tagagaccgg cgctcccctt     60

tcccctcccg ccggacctgc caggaggtgg gctggcgcgg agggagggcc ctgtcccctg    120

tccctttaag gaggagggcc aaacgccggc ctagagtgcg gcgtagcccc cacccgccgt    180

gccctcaccc cagagcagct gcagcctcag ccggccgccc ctccgccagc caagtccgcc    240

gctctgaccc ccggcagcaa gtcgccacca tggtgaagat cgtgacagtt aagacccagg    300

cgtaccagga ccagaagccg ggcacgagcg ggctgcggaa gcgggtgaag gtgttccaga    360

gcagcgccaa ctacgcggag aacttcatcc agagtatcat ctccaccgtg gagccggcgc    420

agcggcagga ggccacgctg gtggtgggcg gggacggccg gttctacatg aaggaggcca    480

tccagctcat cgctcgcatc gctgccgcca acgggatcgg tcgcttggtt atcggacaga    540

atggaatcct ctccacccct gctgtatcct gcatcattag aaaaatcaaa gccattggtg    600

ggatcattct gacagccagt cacaacccag ggggccccaa tggagatttt ggaatcaaat    660

tcaatatttc taatggaggt cctgctccag aagcaataac tgataaaatt ttccaaatca    720

gcaagacaat tgaagaatat gcagtttgcc ctgacctgaa agtagacctt ggtgttctgg    780

gaaagcagca gtttgacttg gaaaataagt tcaaaccctt cacagtggaa attgtggatt    840

cggtagaagc ttatgctaca atgctgagaa gcatctttga tttcagtgca ctgaaagaac    900

tactttctgg gccaaaccga ctgaagatcc gtattgatgc tatgcatgga gttgtgggac    960

cgtatgtaaa gaagatcctc tgtgaagaac tcggtgcccc tgcgaactcg gcagttaact   1020

gcgttcctct ggaggacttt ggaggccacc accctgaccc caacctcacc tatgcagctg   1080

acctggtgga gaccatgaag tcaggagagc atgattttgg ggctgccttt gatggagatg   1140

gggatcgaaa catgattctg ggcaagcatg ggttctttgt gaacccttca gactctgtgg   1200

ctgtcattgc tgccaacatc ttcagcattc cgtatttcca gcagactggg gtccgcggct   1260

ttgcacggag catgcccacg agtggtgctc tggaccgggt ggctagtgct acaaagattg   1320

ctttgtatga gaccccaact ggctggaagt tttttgggaa tttgatggac gcgagcaaac   1380

tgtccctttg tggggaggag agcttcggga ccggttctga ccacatccgt gagaaagatg   1440

gactgtgggc tgtccttgcc tggctctcca tcctagccac ccgcaagcag agtgtggagg   1500

acattctcaa agatcattgg caaaagtatg gccggaattt cttcaccagg tatgattacg   1560

aggaggtgga agctgagggc gcaaacaaaa tgatgaagga cttggaggcc ctgatgtttg   1620

atcgctcctt tgtggggaag cagttctcag caaatgacaa agtttacact gtggagaagg   1680

ccgataactt tgaatacagc gacccagtgg atggaagcat ttcaagaaat cagggcttgc   1740

gcctcatttt cacagatggt tctcgaatcg tcttccgact gagcggcact gggagtgccg   1800

gggccaccat tcggctgtac atcgatagct atgagaagga cgttgccaag attaaccagg   1860

acccccaggt catgttggcc ccccttattt ccattgctct gaaagtgtcc cagctgcagg   1920

agaggacggg acgcactgca cccactgtca tcacctaaga agacaggcct gatgtggtac   1980

gtccctccac ccccggaccc atccaagtca tctgattgaa gagcatgaca gaaacaaaat   2040

gtattcacca agcattttag gatttgactt tttcactaac cagttgacga gcagtgcatt   2100

tacaaggcac tgccaaacaa gatgcccttg ggagctgtga gggaaagagg acctgcgggc   2160

ttagatcaat ctcaattcct tttcatgccc tcctgcattg ctgctgcgtg ggtatttgtc   2220

tccttagcca tcaggtacag tttacactac aatgtaagct ataggtggag catcagcagt   2280

gagtgaggcc attcttcatc cttaggatgt ggcaatgaaa tgatggtgca agttcctttc   2340

tcttttgtga atctttcccc ccatttcctg tttacatgta acccaacaaa atgcaatttc   2400

tagtgccttc tgtccaatca gttctttcct ctgagtgaga cgtacttggc tacagatttc   2460

tgccttgttt tgcgacattg tcccattcac acagatattt tgggataata aaggaaaata   2520

agctacaa                                                            2528


<210>  573
<211>  562
<212>  PRT
<213>  Homo sapiens

<400>  573


Met Val Lys Ile Val Thr Val Lys Thr Gln Ala Tyr Gln Asp Gln Lys 
1               5                   10                  15      


Pro Gly Thr Ser Gly Leu Arg Lys Arg Val Lys Val Phe Gln Ser Ser 
            20                  25                  30          


Ala Asn Tyr Ala Glu Asn Phe Ile Gln Ser Ile Ile Ser Thr Val Glu 
        35                  40                  45              


Pro Ala Gln Arg Gln Glu Ala Thr Leu Val Val Gly Gly Asp Gly Arg 
    50                  55                  60                  


Phe Tyr Met Lys Glu Ala Ile Gln Leu Ile Ala Arg Ile Ala Ala Ala 
65                  70                  75                  80  


Asn Gly Ile Gly Arg Leu Val Ile Gly Gln Asn Gly Ile Leu Ser Thr 
                85                  90                  95      


Pro Ala Val Ser Cys Ile Ile Arg Lys Ile Lys Ala Ile Gly Gly Ile 
            100                 105                 110         


Ile Leu Thr Ala Ser His Asn Pro Gly Gly Pro Asn Gly Asp Phe Gly 
        115                 120                 125             


Ile Lys Phe Asn Ile Ser Asn Gly Gly Pro Ala Pro Glu Ala Ile Thr 
    130                 135                 140                 


Asp Lys Ile Phe Gln Ile Ser Lys Thr Ile Glu Glu Tyr Ala Val Cys 
145                 150                 155                 160 


Pro Asp Leu Lys Val Asp Leu Gly Val Leu Gly Lys Gln Gln Phe Asp 
                165                 170                 175     


Leu Glu Asn Lys Phe Lys Pro Phe Thr Val Glu Ile Val Asp Ser Val 
            180                 185                 190         


Glu Ala Tyr Ala Thr Met Leu Arg Ser Ile Phe Asp Phe Ser Ala Leu 
        195                 200                 205             


Lys Glu Leu Leu Ser Gly Pro Asn Arg Leu Lys Ile Arg Ile Asp Ala 
    210                 215                 220                 


Met His Gly Val Val Gly Pro Tyr Val Lys Lys Ile Leu Cys Glu Glu 
225                 230                 235                 240 


Leu Gly Ala Pro Ala Asn Ser Ala Val Asn Cys Val Pro Leu Glu Asp 
                245                 250                 255     


Phe Gly Gly His His Pro Asp Pro Asn Leu Thr Tyr Ala Ala Asp Leu 
            260                 265                 270         


Val Glu Thr Met Lys Ser Gly Glu His Asp Phe Gly Ala Ala Phe Asp 
        275                 280                 285             


Gly Asp Gly Asp Arg Asn Met Ile Leu Gly Lys His Gly Phe Phe Val 
    290                 295                 300                 


Asn Pro Ser Asp Ser Val Ala Val Ile Ala Ala Asn Ile Phe Ser Ile 
305                 310                 315                 320 


Pro Tyr Phe Gln Gln Thr Gly Val Arg Gly Phe Ala Arg Ser Met Pro 
                325                 330                 335     


Thr Ser Gly Ala Leu Asp Arg Val Ala Ser Ala Thr Lys Ile Ala Leu 
            340                 345                 350         


Tyr Glu Thr Pro Thr Gly Trp Lys Phe Phe Gly Asn Leu Met Asp Ala 
        355                 360                 365             


Ser Lys Leu Ser Leu Cys Gly Glu Glu Ser Phe Gly Thr Gly Ser Asp 
    370                 375                 380                 


His Ile Arg Glu Lys Asp Gly Leu Trp Ala Val Leu Ala Trp Leu Ser 
385                 390                 395                 400 


Ile Leu Ala Thr Arg Lys Gln Ser Val Glu Asp Ile Leu Lys Asp His 
                405                 410                 415     


Trp Gln Lys Tyr Gly Arg Asn Phe Phe Thr Arg Tyr Asp Tyr Glu Glu 
            420                 425                 430         


Val Glu Ala Glu Gly Ala Asn Lys Met Met Lys Asp Leu Glu Ala Leu 
        435                 440                 445             


Met Phe Asp Arg Ser Phe Val Gly Lys Gln Phe Ser Ala Asn Asp Lys 
    450                 455                 460                 


Val Tyr Thr Val Glu Lys Ala Asp Asn Phe Glu Tyr Ser Asp Pro Val 
465                 470                 475                 480 


Asp Gly Ser Ile Ser Arg Asn Gln Gly Leu Arg Leu Ile Phe Thr Asp 
                485                 490                 495     


Gly Ser Arg Ile Val Phe Arg Leu Ser Gly Thr Gly Ser Ala Gly Ala 
            500                 505                 510         


Thr Ile Arg Leu Tyr Ile Asp Ser Tyr Glu Lys Asp Val Ala Lys Ile 
        515                 520                 525             


Asn Gln Asp Pro Gln Val Met Leu Ala Pro Leu Ile Ser Ile Ala Leu 
    530                 535                 540                 


Lys Val Ser Gln Leu Gln Glu Arg Thr Gly Arg Thr Ala Pro Thr Val 
545                 550                 555                 560 


Ile Thr 
        

<210>  574
<211>  700
<212>  DNA
<213>  Homo sapiens

<400>  574
atgcagctga cctggtggag accatgaagt caggagagca tgattttggg gctgccttat     60

ttccattgct ctgaaagtgt cccagctgca ggagaggacg ggacgcactg cacccactgt    120

catcacctaa gaagacaggc ctgatgtggt acgtccctcc acccccggac ccatccaagt    180

catctgattg aagagcatga cagaaacaaa atgtattcac caagcatttt aggatttgac    240

tttttcacta accagttgac gagcagtgca tttacaaggc actgccaaac aagatgccct    300

tgggagctgt gagggaaaga ggacctgcgg gcttagatca atctcaattc cttttcatgc    360

cctcctgcat tgctgctgcg tgggtatttg tctccttagc catcaggtac agtttacact    420

acaatgtaag ctataggtgg agcatcagca gtgagtgagg ccattcttca tccttaggat    480

gtggcaatga aatgatggtg caagttcctt tctcttttgt gaatctttcc ccccatttcc    540

tgtttacatg taacccaaca aaatgcaatt tctagtgcct tctgtccaat cagttctttc    600

ctctgagtga gacgtacttg gctacagatt tctgccttgt tttgcgacat tgtcccattc    660

acacagatat tttgggataa taaaggaaaa taagctacaa                          700


<210>  575
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  575


Met Ile Leu Gly Leu Pro Tyr Phe His Cys Ser Glu Ser Val Pro Ala 
1               5                   10                  15      


Ala Gly Glu Asp Gly Thr His Cys Thr His Cys His His Leu Arg Arg 
            20                  25                  30          


Gln Ala 
        

<210>  576
<211>  453
<212>  DNA
<213>  Homo sapiens

<400>  576
atgccgcgag cgcgatccct tcccagccct ctggctgcag cctcgcctgg gccggcgggt     60

cagtcccagg ctgtccgggt cgcaccagtg ggcgtgagtc gccctgggtc ggactccgag    120

aacagcgcac cctgcgccca ggggctgccg tcccggggct ccctcggcgg cggcggtggc    180

ggctgctcca gctctccacg ctccctctct cgctcaactt gtcactttcc accaactctc    240

cagcccagcg ccccagcccc gaccaatggg agacgcggcc caggctggcg acccagcgcc    300

ctctgctgca gcctctcaac gcccgcaccc tccccgactt cgcagaaagc ggtcgcggct    360

cccgcgtctc gggcacgctc cctcccctcc cctcccccac actcctcaaa ctcgccaccg    420

aaccgagcgc cggggacctt cgaggctact tga                                 453


<210>  577
<211>  150
<212>  PRT
<213>  Homo sapiens

<400>  577


Met Pro Arg Ala Arg Ser Leu Pro Ser Pro Leu Ala Ala Ala Ser Pro 
1               5                   10                  15      


Gly Pro Ala Gly Gln Ser Gln Ala Val Arg Val Ala Pro Val Gly Val 
            20                  25                  30          


Ser Arg Pro Gly Ser Asp Ser Glu Asn Ser Ala Pro Cys Ala Gln Gly 
        35                  40                  45              


Leu Pro Ser Arg Gly Ser Leu Gly Gly Gly Gly Gly Gly Cys Ser Ser 
    50                  55                  60                  


Ser Pro Arg Ser Leu Ser Arg Ser Thr Cys His Phe Pro Pro Thr Leu 
65                  70                  75                  80  


Gln Pro Ser Ala Pro Ala Pro Thr Asn Gly Arg Arg Gly Pro Gly Trp 
                85                  90                  95      


Arg Pro Ser Ala Leu Cys Cys Ser Leu Ser Thr Pro Ala Pro Ser Pro 
            100                 105                 110         


Thr Ser Gln Lys Ala Val Ala Ala Pro Ala Ser Arg Ala Arg Ser Leu 
        115                 120                 125             


Pro Ser Pro Pro Pro His Ser Ser Asn Ser Pro Pro Asn Arg Ala Pro 
    130                 135                 140                 


Gly Thr Phe Glu Ala Thr 
145                 150 

<210>  578
<211>  2693
<212>  DNA
<213>  Homo sapiens

<400>  578
gttgagcgag agagggagcg tggagagctg gagcagccgc caccgccgcc gccgagggag     60

ccccgggacg gcagcccctg ggcgcagggt gcgctgttct cggagtccga cccagggcga    120

ctcacgccca ctggtgcgac ccggacagcc tgggactgac ccgccggccc aggcgaggct    180

gcagccagag ggctgggaag ggatcgcgct cgcggcatcc agaggcggcc aggcggaggc    240

gagggagcag gttagaggga caaagagctt tgcagacgtc cccggcgtcc tgcgagcgcc    300

agcggccggg acgaggcggc cgggagcccg ggaagagccc gtggatgttc tgcgcgcggc    360

ctgggagccg ccgccgccgc cgcctcagcg agaggaggaa tgcaccggcc gcgccgccgc    420

gggacgcgcc cgccgctcct ggcgctgctg gccgcgctgc tgctggccgc acgcggggct    480

gctgcccaag aaacagagct gtcagtcagt gctgaattag tgcctacctc atcatggaac    540

atctcaagtg aactcaacaa agattcttac ctgaccctcg atgaaccaat gaataacatc    600

accacgtctc tgggccagac agcagaactg cactgcaaag tctctgggaa tccacctccc    660

accatccgct ggttcaaaaa tgatgctcct gtggtccagg agccccggag gctctccttt    720

cggtccacca tctatggctc tcggctgcgg attagaaacc tcgacaccac agacacaggc    780

tacttccagt gcgtggcaac aaacggcaag gaggtggttt cttccactgg agtcttgttt    840

gtcaagtttg gcccccctcc cactgcaagt ccaggatact cagatgagta tgaagaagat    900

ggattctgtc agccatacag agggattgca tgtgcaagat ttattggcaa ccgcaccgtc    960

tatatggagt ctttgcacat gcaaggggaa atagaaaatc agatcacagc tgccttcact   1020

atgattggca cttccagtca cttatctgat aagtgttctc agttcgccat tccttccctg   1080

tgccactatg ccttcccgta ctgcgatgaa acttcatccg tcccaaagcc ccgtgacttg   1140

tgtcgcgatg aatgtgaaat cctggagaat gtcctgtgtc aaacagagta catttttgca   1200

agatcaaatc ccatgattct gatgaggctg aaactgccaa actgtgaaga tctcccccag   1260

ccagagagcc cagaagctgc gaactgtatc cggattggaa ttcccatggc agatcctata   1320

aataaaaatc acaagtgtta taacagcaca ggtgtggact accgggggac cgtcagtgtg   1380

accaaatcag ggcgccagtg ccagccatgg aattcccagt atccccacac acacactttc   1440

accgcccttc gtttcccaga gctgaatgga ggccattcct actgccgcaa cccagggaat   1500

caaaaggaag ctccctggtg cttcaccttg gatgaaaact ttaagtctga tctgtgtgac   1560

atcccagcgt gcggtaaata gaagtcattg cccctaatgt attcaatcat ctttaaagat   1620

ccctatccta cccctcttat ttaggagaat cctataaggg gggcaaagaa aatggacagt   1680

atttgcttga tctcaatctg gttttagggt aaaccttgcc gtttctacat aaaacacctc   1740

gtaaggtacc aaaacacgtt ctcaagaagt caactgcctt tatacctgca gccattgcac   1800

tcatggatgt aacagggacc cagcccttca gaggcacagt tgagacagtt tatcacattg   1860

atttttatag aaaaagatgt tacccagaat ggtctgcgtc caagtggacc ttttcagcaa   1920

aaaaaggaat attggaagca ggaagaaatt gttttctgta tgccttaaga acaccacaag   1980

gcaggatgaa tctacaacca ttactcggtc atccaggaca atctgtgggt aaactgtgtc   2040

cttcgttatg tctgttaata ctgcagaaga agcatatagg tatctagtaa gaaaatggaa   2100

ttcctgagtc agttaactgt tcctttttct agaaaatgtt tggagaaaat aatgaaaatg   2160

ggccaagcat ggtggcttat acctgtaatc ccaacactct aggaaggccg aggcaggagg   2220

atcatttgag cccaggggtt caagaccagc ccaggcaaca tagtgagact ccatctctac   2280

caaaaaaaag aaaaaaaaaa aaagaaaatg ttggtgaaac ctggagttag gaactatttt   2340

ggaactaatt catcttcctg atcctagttc tcatagatat catagataat gccaagtttc   2400

ccaggcatag tgggagagtc aggatgtcac tgctggaaaa gcaaaagcta cagggtagga   2460

gggtgggcaa acaagagcaa tagtcatggg acccacaata caaagtgagc tcggtgttta   2520

accagatgat tattcaagcc attcattcag aatatttgtt gagtacctac taagtgccaa   2580

gtacttactc atccgagcat ggggagacgc cagggaccct aaggagggag taggcatagc   2640

acatccacaa agaagcaagg agtcatggag gcggaacaag caaaagggag agt          2693


<210>  579
<211>  393
<212>  PRT
<213>  Homo sapiens

<400>  579


Met His Arg Pro Arg Arg Arg Gly Thr Arg Pro Pro Leu Leu Ala Leu 
1               5                   10                  15      


Leu Ala Ala Leu Leu Leu Ala Ala Arg Gly Ala Ala Ala Gln Glu Thr 
            20                  25                  30          


Glu Leu Ser Val Ser Ala Glu Leu Val Pro Thr Ser Ser Trp Asn Ile 
        35                  40                  45              


Ser Ser Glu Leu Asn Lys Asp Ser Tyr Leu Thr Leu Asp Glu Pro Met 
    50                  55                  60                  


Asn Asn Ile Thr Thr Ser Leu Gly Gln Thr Ala Glu Leu His Cys Lys 
65                  70                  75                  80  


Val Ser Gly Asn Pro Pro Pro Thr Ile Arg Trp Phe Lys Asn Asp Ala 
                85                  90                  95      


Pro Val Val Gln Glu Pro Arg Arg Leu Ser Phe Arg Ser Thr Ile Tyr 
            100                 105                 110         


Gly Ser Arg Leu Arg Ile Arg Asn Leu Asp Thr Thr Asp Thr Gly Tyr 
        115                 120                 125             


Phe Gln Cys Val Ala Thr Asn Gly Lys Glu Val Val Ser Ser Thr Gly 
    130                 135                 140                 


Val Leu Phe Val Lys Phe Gly Pro Pro Pro Thr Ala Ser Pro Gly Tyr 
145                 150                 155                 160 


Ser Asp Glu Tyr Glu Glu Asp Gly Phe Cys Gln Pro Tyr Arg Gly Ile 
                165                 170                 175     


Ala Cys Ala Arg Phe Ile Gly Asn Arg Thr Val Tyr Met Glu Ser Leu 
            180                 185                 190         


His Met Gln Gly Glu Ile Glu Asn Gln Ile Thr Ala Ala Phe Thr Met 
        195                 200                 205             


Ile Gly Thr Ser Ser His Leu Ser Asp Lys Cys Ser Gln Phe Ala Ile 
    210                 215                 220                 


Pro Ser Leu Cys His Tyr Ala Phe Pro Tyr Cys Asp Glu Thr Ser Ser 
225                 230                 235                 240 


Val Pro Lys Pro Arg Asp Leu Cys Arg Asp Glu Cys Glu Ile Leu Glu 
                245                 250                 255     


Asn Val Leu Cys Gln Thr Glu Tyr Ile Phe Ala Arg Ser Asn Pro Met 
            260                 265                 270         


Ile Leu Met Arg Leu Lys Leu Pro Asn Cys Glu Asp Leu Pro Gln Pro 
        275                 280                 285             


Glu Ser Pro Glu Ala Ala Asn Cys Ile Arg Ile Gly Ile Pro Met Ala 
    290                 295                 300                 


Asp Pro Ile Asn Lys Asn His Lys Cys Tyr Asn Ser Thr Gly Val Asp 
305                 310                 315                 320 


Tyr Arg Gly Thr Val Ser Val Thr Lys Ser Gly Arg Gln Cys Gln Pro 
                325                 330                 335     


Trp Asn Ser Gln Tyr Pro His Thr His Thr Phe Thr Ala Leu Arg Phe 
            340                 345                 350         


Pro Glu Leu Asn Gly Gly His Ser Tyr Cys Arg Asn Pro Gly Asn Gln 
        355                 360                 365             


Lys Glu Ala Pro Trp Cys Phe Thr Leu Asp Glu Asn Phe Lys Ser Asp 
    370                 375                 380                 


Leu Cys Asp Ile Pro Ala Cys Gly Lys 
385                 390             

<210>  580
<211>  3796
<212>  DNA
<213>  Homo sapiens

<400>  580
cgagagaggg agcgtggaga gctggagcag ccgccaccgc cgccgccgag ggagccccgg     60

gacggcagcc cctgggcgca gggtgcgctg ttctcggagt ccgacccagg gcgactcacg    120

cccactggtg cgacccggac agcctgggac tgacccgccg gcccaggcga ggctgcagcc    180

agagggctgg gaagggatcg cgctcgcggc atccagaggc ggccaggcgg aggcgaggga    240

gcaggttaga gggacaaaga gctttgcaga cgtccccggc gtcctgcgag cgccagcggc    300

cgggacgagg cggccgggag cccgggaaga gcccgtggat gttctgcgcg cggcctggga    360

gccgccgccg ccgccgcctc agcgagagga ggaatgcacc ggccgcgccg ccgcgggacg    420

cgcccgccgc tcctggcgct gctggccgcg ctgctgctgg ccgcacgcgg ggctgctgcc    480

caagaaacag agctgtcagt cagtgctgaa ttagtgccta cctcatcatg gaacatctca    540

agtgaactca acaaagattc ttacctgacc ctcgatgaac caatgaataa catcaccacg    600

tctctgggcc agacagcaga actgcactgc aaagtctctg ggaatccacc tcccaccatc    660

cgctggttca aaaatgatgc tcctgtggtc caggagcccc ggaggctctc ctttcggtcc    720

accatctatg gctctcggct gcggattaga aacctcgaca ccacagacac aggctacttc    780

cagtgcgtgg caacaaacgg caaggaggtg gtttcttcca ctggagtctt gtttgtcaag    840

tttggccccc ctcccactgc aagtccagga tactcagatg agtatgaaga agatggattc    900

tgtcagccat acagagggat tgcatgtgca agatttattg gcaaccgcac cgtctatatg    960

gagtctttgc acatgcaagg ggaaatagaa aatcagatca cagctgcctt cactatgatt   1020

ggcacttcca gtcacttatc tgataagtgt tctcagttcg ccattccttc cctgtgccac   1080

tatgccttcc cgtactgcga tgaaacttca tccgtcccaa agccccgtga cttgtgtcgc   1140

gatgaatgtg aaatcctgga gaatgtcctg tgtcaaacag agtacatttt tgcaagatca   1200

aatcccatga ttctgatgag gctgaaactg ccaaactgtg aagatctccc ccagccagag   1260

agcccagaag ctgcgaactg tatccggatt ggaattccca tggcagatcc tataaataaa   1320

aatcacaagt gttataacag cacaggtgtg gactaccggg ggaccgtcag tgtgaccaaa   1380

tcagggcgcc agtgccagcc atggaattcc cagtatcccc acacacacac tttcaccgcc   1440

cttcgtttcc cagagctgaa tggaggccat tcctactgcc gcaacccagg gaatcaaaag   1500

gaagctccct ggtgcttcac cttggatgaa aactttaagt ctgatctgtg tgacatccca   1560

gcgtgcgatt caaaggattc caaggagaag aataaaatgg aaatcctgta catactagtg   1620

ccaagtgtgg ccattcccct ggccattgct ttactcttct tcttcatttg cgtctgtcgg   1680

aataaccaga agtcatcgtc ggcaccagtc cagaggcaac caaaacacgt cagaggtcaa   1740

aatgtagaga tgtcaatgct gaatgcatat aaacccaaga gcaaggctaa agagctacct   1800

ctttctgctg tacgctttat ggaagaattg ggtgagtgtg cctttggaaa aatctataaa   1860

ggccatctct atctcccagg catggaccat gctcagctgg ttgctatcaa gaccttgaaa   1920

gactataaca acccccagca atggacggaa tttcaacaag aagcctccct aatggcagaa   1980

ctgcaccacc ccaatattgt ctgccttcta ggtgccgtca ctcaggaaca acctgtgtgc   2040

atgctttttg agtatattaa tcagggggat ctccatgagt tcctcatcat gagatcccca   2100

cactctgatg ttggctgcag cagtgatgaa gatgggactg tgaaatccag cctggaccac   2160

ggagattttc tgcacattgc aattcagatt gcagctggca tggaatacct gtctagtcac   2220

ttctttgtcc acaaggacct tgcagctcgc aatattttaa tcggagagca acttcatgta   2280

aagatttcag acttggggct ttccagagaa atttactccg ctgattacta cagggtccag   2340

agtaagtcct tgctgcccat tcgctggatg ccccctgaag ccatcatgta tggcaaattc   2400

tcttctgatt cagatatctg gtcctttggg gttgtcttgt gggagatttt cagttttgga   2460

ctccagccat attatggatt cagtaaccag gaagtgattg agatggtgag aaaacggcag   2520

ctcttaccat gctctgaaga ctgcccaccc agaatgtaca gcctcatgac agagtgctgg   2580

aatgagattc cttctaggag accaagattt aaagatattc acgtccggct tcggtcctgg   2640

gagggactct caagtcacac aagctctact actccttcag ggggaaatgc caccacacag   2700

acaacctccc tcagtgccag cccagtgagt aatctcagta accccagata tcctaattac   2760

atgttcccga gccagggtat tacaccacag ggccagattg ctggtttcat tggcccgcca   2820

atacctcaga accagcgatt cattcccatc aatggatacc caatacctcc tggatatgca   2880

gcgtttccag ctgcccacta ccagccaaca ggtcctccca gagtgattca gcactgccca   2940

cctcccaaga gtcggtcccc aagcagtgcc agtgggtcga ctagcactgg ccatgtgact   3000

agcttgccct catcaggatc caatcaggaa gcaaatattc ctttactacc acacatgtca   3060

attccaaatc atcctggtgg aatgggtatc accgtttttg gcaacaaatc tcaaaaaccc   3120

tacaaaattg actcaaagca agcatcttta ctaggagacg ccaatattca tggacacacc   3180

gaatctatga tttctgcaga actgtaaaat gcacaacttt tgtaaatgtg gtatacagga   3240

caaactagac ggccgtagaa aagatttata ttcaaatgtt tttattaaag taaggttctc   3300

atttagcaga catcgcaaca agtaccttct gtgaagtttc actgtgtctt accaagcagg   3360

acagacactc ggccagaaaa aaaaaaaaaa aaaaaaaaca agcaaacaaa aacattgtgg   3420

gatgtgcact ccattggagt gcatgacatg gcattgggat tggaacatgt ggtttcgagc   3480

actgaaagct gcaaaccagt gaagaggaaa agaaccttgt gattaaatat aaaaccaaaa   3540

gtcaaatggt gctttgtgtt ttagccttca gtcaccatga ctggtctctc ccccagatgt   3600

atatatacca tagcatttgt ctacctgctg tcttttcttc aggacagatg ttcaggaatt   3660

atattgattg aatttagact ctgtgcatgt tcttatggaa atgatgttca gaatccatga   3720

agaaacttca ggccaaattt gaaaccctgg agggaaatga gccataaggg aagtataaca   3780

agccctgaag cctttt                                                   3796


<210>  581
<211>  937
<212>  PRT
<213>  Homo sapiens

<400>  581


Met His Arg Pro Arg Arg Arg Gly Thr Arg Pro Pro Leu Leu Ala Leu 
1               5                   10                  15      


Leu Ala Ala Leu Leu Leu Ala Ala Arg Gly Ala Ala Ala Gln Glu Thr 
            20                  25                  30          


Glu Leu Ser Val Ser Ala Glu Leu Val Pro Thr Ser Ser Trp Asn Ile 
        35                  40                  45              


Ser Ser Glu Leu Asn Lys Asp Ser Tyr Leu Thr Leu Asp Glu Pro Met 
    50                  55                  60                  


Asn Asn Ile Thr Thr Ser Leu Gly Gln Thr Ala Glu Leu His Cys Lys 
65                  70                  75                  80  


Val Ser Gly Asn Pro Pro Pro Thr Ile Arg Trp Phe Lys Asn Asp Ala 
                85                  90                  95      


Pro Val Val Gln Glu Pro Arg Arg Leu Ser Phe Arg Ser Thr Ile Tyr 
            100                 105                 110         


Gly Ser Arg Leu Arg Ile Arg Asn Leu Asp Thr Thr Asp Thr Gly Tyr 
        115                 120                 125             


Phe Gln Cys Val Ala Thr Asn Gly Lys Glu Val Val Ser Ser Thr Gly 
    130                 135                 140                 


Val Leu Phe Val Lys Phe Gly Pro Pro Pro Thr Ala Ser Pro Gly Tyr 
145                 150                 155                 160 


Ser Asp Glu Tyr Glu Glu Asp Gly Phe Cys Gln Pro Tyr Arg Gly Ile 
                165                 170                 175     


Ala Cys Ala Arg Phe Ile Gly Asn Arg Thr Val Tyr Met Glu Ser Leu 
            180                 185                 190         


His Met Gln Gly Glu Ile Glu Asn Gln Ile Thr Ala Ala Phe Thr Met 
        195                 200                 205             


Ile Gly Thr Ser Ser His Leu Ser Asp Lys Cys Ser Gln Phe Ala Ile 
    210                 215                 220                 


Pro Ser Leu Cys His Tyr Ala Phe Pro Tyr Cys Asp Glu Thr Ser Ser 
225                 230                 235                 240 


Val Pro Lys Pro Arg Asp Leu Cys Arg Asp Glu Cys Glu Ile Leu Glu 
                245                 250                 255     


Asn Val Leu Cys Gln Thr Glu Tyr Ile Phe Ala Arg Ser Asn Pro Met 
            260                 265                 270         


Ile Leu Met Arg Leu Lys Leu Pro Asn Cys Glu Asp Leu Pro Gln Pro 
        275                 280                 285             


Glu Ser Pro Glu Ala Ala Asn Cys Ile Arg Ile Gly Ile Pro Met Ala 
    290                 295                 300                 


Asp Pro Ile Asn Lys Asn His Lys Cys Tyr Asn Ser Thr Gly Val Asp 
305                 310                 315                 320 


Tyr Arg Gly Thr Val Ser Val Thr Lys Ser Gly Arg Gln Cys Gln Pro 
                325                 330                 335     


Trp Asn Ser Gln Tyr Pro His Thr His Thr Phe Thr Ala Leu Arg Phe 
            340                 345                 350         


Pro Glu Leu Asn Gly Gly His Ser Tyr Cys Arg Asn Pro Gly Asn Gln 
        355                 360                 365             


Lys Glu Ala Pro Trp Cys Phe Thr Leu Asp Glu Asn Phe Lys Ser Asp 
    370                 375                 380                 


Leu Cys Asp Ile Pro Ala Cys Asp Ser Lys Asp Ser Lys Glu Lys Asn 
385                 390                 395                 400 


Lys Met Glu Ile Leu Tyr Ile Leu Val Pro Ser Val Ala Ile Pro Leu 
                405                 410                 415     


Ala Ile Ala Leu Leu Phe Phe Phe Ile Cys Val Cys Arg Asn Asn Gln 
            420                 425                 430         


Lys Ser Ser Ser Ala Pro Val Gln Arg Gln Pro Lys His Val Arg Gly 
        435                 440                 445             


Gln Asn Val Glu Met Ser Met Leu Asn Ala Tyr Lys Pro Lys Ser Lys 
    450                 455                 460                 


Ala Lys Glu Leu Pro Leu Ser Ala Val Arg Phe Met Glu Glu Leu Gly 
465                 470                 475                 480 


Glu Cys Ala Phe Gly Lys Ile Tyr Lys Gly His Leu Tyr Leu Pro Gly 
                485                 490                 495     


Met Asp His Ala Gln Leu Val Ala Ile Lys Thr Leu Lys Asp Tyr Asn 
            500                 505                 510         


Asn Pro Gln Gln Trp Thr Glu Phe Gln Gln Glu Ala Ser Leu Met Ala 
        515                 520                 525             


Glu Leu His His Pro Asn Ile Val Cys Leu Leu Gly Ala Val Thr Gln 
    530                 535                 540                 


Glu Gln Pro Val Cys Met Leu Phe Glu Tyr Ile Asn Gln Gly Asp Leu 
545                 550                 555                 560 


His Glu Phe Leu Ile Met Arg Ser Pro His Ser Asp Val Gly Cys Ser 
                565                 570                 575     


Ser Asp Glu Asp Gly Thr Val Lys Ser Ser Leu Asp His Gly Asp Phe 
            580                 585                 590         


Leu His Ile Ala Ile Gln Ile Ala Ala Gly Met Glu Tyr Leu Ser Ser 
        595                 600                 605             


His Phe Phe Val His Lys Asp Leu Ala Ala Arg Asn Ile Leu Ile Gly 
    610                 615                 620                 


Glu Gln Leu His Val Lys Ile Ser Asp Leu Gly Leu Ser Arg Glu Ile 
625                 630                 635                 640 


Tyr Ser Ala Asp Tyr Tyr Arg Val Gln Ser Lys Ser Leu Leu Pro Ile 
                645                 650                 655     


Arg Trp Met Pro Pro Glu Ala Ile Met Tyr Gly Lys Phe Ser Ser Asp 
            660                 665                 670         


Ser Asp Ile Trp Ser Phe Gly Val Val Leu Trp Glu Ile Phe Ser Phe 
        675                 680                 685             


Gly Leu Gln Pro Tyr Tyr Gly Phe Ser Asn Gln Glu Val Ile Glu Met 
    690                 695                 700                 


Val Arg Lys Arg Gln Leu Leu Pro Cys Ser Glu Asp Cys Pro Pro Arg 
705                 710                 715                 720 


Met Tyr Ser Leu Met Thr Glu Cys Trp Asn Glu Ile Pro Ser Arg Arg 
                725                 730                 735     


Pro Arg Phe Lys Asp Ile His Val Arg Leu Arg Ser Trp Glu Gly Leu 
            740                 745                 750         


Ser Ser His Thr Ser Ser Thr Thr Pro Ser Gly Gly Asn Ala Thr Thr 
        755                 760                 765             


Gln Thr Thr Ser Leu Ser Ala Ser Pro Val Ser Asn Leu Ser Asn Pro 
    770                 775                 780                 


Arg Tyr Pro Asn Tyr Met Phe Pro Ser Gln Gly Ile Thr Pro Gln Gly 
785                 790                 795                 800 


Gln Ile Ala Gly Phe Ile Gly Pro Pro Ile Pro Gln Asn Gln Arg Phe 
                805                 810                 815     


Ile Pro Ile Asn Gly Tyr Pro Ile Pro Pro Gly Tyr Ala Ala Phe Pro 
            820                 825                 830         


Ala Ala His Tyr Gln Pro Thr Gly Pro Pro Arg Val Ile Gln His Cys 
        835                 840                 845             


Pro Pro Pro Lys Ser Arg Ser Pro Ser Ser Ala Ser Gly Ser Thr Ser 
    850                 855                 860                 


Thr Gly His Val Thr Ser Leu Pro Ser Ser Gly Ser Asn Gln Glu Ala 
865                 870                 875                 880 


Asn Ile Pro Leu Leu Pro His Met Ser Ile Pro Asn His Pro Gly Gly 
                885                 890                 895     


Met Gly Ile Thr Val Phe Gly Asn Lys Ser Gln Lys Pro Tyr Lys Ile 
            900                 905                 910         


Asp Ser Lys Gln Ala Ser Leu Leu Gly Asp Ala Asn Ile His Gly His 
        915                 920                 925             


Thr Glu Ser Met Ile Ser Ala Glu Leu 
    930                 935         

<210>  582
<211>  2898
<212>  DNA
<213>  Homo sapiens

<400>  582
gctgacattt ccattgacct cagaagtgaa aatctaaagt gagtgctgac aggcaggcag     60

tgaggaaaga agacatgaca cagccaacaa gggtggcagc ctggctctga agtggaatta    120

tgtgcttcaa acaggttgaa agagggaaac agtcttttcc tgcttccaga catgaatcag    180

gtcactattc aatgggatgc agtaatagcc ctttacatac tcttcagctg gtgtcatgga    240

ggaattacaa atataaactg ctctggccac atctgggtag aaccagccac aatttttaag    300

atgggtatga atatctctat atattgccaa gcagcaatta agaactgcca accaaggaaa    360

cttcattttt ataaaaatgg catcaaagaa agatttcaaa tcacaaggat taataaaaca    420

acagctcggc tttggtataa aaactttctg gaaccacatg cttctatgta ctgcactgct    480

gaatgtccca aacattttca agagacactg atatgtggaa aagacatttc ttctggatat    540

ccgccagata ttcctgatga agtaacctgt gtcatttatg aatattcagg caacatgact    600

tgcacctgga atgctgggaa gctcacctac atagacacaa aatacgtggt acatgtgaag    660

agtttagaga cagaagaaga gcaacagtat ctcacctcaa gctatattaa catctccact    720

gattcattac aaggtggcaa gaagtacttg gtttgggtcc aagcagcaaa cgcactaggc    780

atggaagagt caaaacaact gcaaattcac ctggatgata tagtgatacc ttctgcagcc    840

gtcatttcca gggctgagac tataaatgct acagtgccca agaccataat ttattgggat    900

agtcaaacaa caattgaaaa ggtttcctgt gaaatgagat acaaggctac aacaaaccaa    960

acttggaatg ttaaagaatt tgacaccaat tttacatatg tgcaacagtc agaattctac   1020

ttggagccaa acattaagta cgtatttcaa gtgagatgtc aagaaacagg caaaaggtac   1080

tggcagcctt ggagttcact gttttttcat aaaacacctg aaacagttcc ccaggtcaca   1140

tcaaaagcat tccaacatga cacatggaat tctgggctaa cagttgcttc catctctaca   1200

gggcacctta cttctgacaa cagaggagac attggacttt tattgggaat gatcgtcttt   1260

gctgttatgt tgtcaattct ttctttgatt gggatattta acagatcatt ccgaactggg   1320

attaaaagaa ggatcttatt gttaatacca aagtggcttt atgaagatat tcctaatatg   1380

aaaaacagca atgttgtgaa aatgctacag gaaaatagtg aacttatgaa taataattcc   1440

agtgagcagg tcctatatgt tgatcccatg attacagaga taaaagaaat cttcatccca   1500

gaacacaagc ctacagacta caagaaggag aatacaggac ccctggagac aagagactac   1560

ccgcaaaact cgctattcga caatactaca gttgtatata ttcctgatct caacactgga   1620

tataaacccc aaatttcaaa ttttctgcct gagggaagcc atctcagcaa taataatgaa   1680

attacttcct taacacttaa accaccagtt gattccttag actcaggaaa taatcccagg   1740

ttacaaaagc atcctaattt tgctttttct gtttcaagtg tgaattcact aagcaacaca   1800

atatttcttg gagaattaag cctcatatta aatcaaggag aatgcagttc tcctgacata   1860

caaaactcag tagaggagga aaccaccatg cttttggaaa atgattcacc cagtgaaact   1920

attccagaac agaccctgct tcctgatgaa tttgtctcct gtttggggat cgtgaatgag   1980

gagttgccat ctattaatac ttattttcca caaaatattt tggaaagcca cttcaatagg   2040

atttcactct tggaaaagta gagctgtgtg gtcaaaatca atatgagaaa gctgccttgc   2100

aatctgaact tgggttttcc ctgcaataga aattgaattc tgcctctttt tgaaaaaaat   2160

gtattcacat acaaatcttc acatggacac atgttttcat ttcccttgga taaataccta   2220

ggtaggggat tgctgggcca tatgataagc atatgtttca gttctaccaa tcttgtttcc   2280

agagtagtga catttctgtg ctcctaccat caccatgtaa gaattcccgg gagctccatg   2340

cctttttaat tttagccatt cttctgcctc atttcttaaa attagagaat taaggtcccg   2400

aaggtggaac atgcttcatg gtcacacata caggcacaaa aacagcatta tgtggacgcc   2460

tcatgtattt tttatagagt caactatttc ctctttattt tccctcattg aaagatgcaa   2520

aacagctctc tattgtgtac agaaagggta aataatgcaa aatacctggt agtaaaataa   2580

atgctgaaaa ttttccttta aaatagaatc attaggccag gcgtggtggc tcatgcttgt   2640

aatcccagca ctttggtagg ctgaggtagg tggatcacct gaggtcagga gttcgagtcc   2700

agcctggcca atatgctgaa accctgtctc tactaaaatt acaaaaatta gccggccatg   2760

gtggcaggtg cttgtaatcc cagctacttg ggaggctgag gcaggagaat cacttgaacc   2820

aggaaggcag aggttgcact gagctgagat tgtgccactg cactccagcc tgggcaacaa   2880

gagcaaaact ctgtctgg                                                 2898


<210>  583
<211>  629
<212>  PRT
<213>  Homo sapiens

<400>  583


Met Asn Gln Val Thr Ile Gln Trp Asp Ala Val Ile Ala Leu Tyr Ile 
1               5                   10                  15      


Leu Phe Ser Trp Cys His Gly Gly Ile Thr Asn Ile Asn Cys Ser Gly 
            20                  25                  30          


His Ile Trp Val Glu Pro Ala Thr Ile Phe Lys Met Gly Met Asn Ile 
        35                  40                  45              


Ser Ile Tyr Cys Gln Ala Ala Ile Lys Asn Cys Gln Pro Arg Lys Leu 
    50                  55                  60                  


His Phe Tyr Lys Asn Gly Ile Lys Glu Arg Phe Gln Ile Thr Arg Ile 
65                  70                  75                  80  


Asn Lys Thr Thr Ala Arg Leu Trp Tyr Lys Asn Phe Leu Glu Pro His 
                85                  90                  95      


Ala Ser Met Tyr Cys Thr Ala Glu Cys Pro Lys His Phe Gln Glu Thr 
            100                 105                 110         


Leu Ile Cys Gly Lys Asp Ile Ser Ser Gly Tyr Pro Pro Asp Ile Pro 
        115                 120                 125             


Asp Glu Val Thr Cys Val Ile Tyr Glu Tyr Ser Gly Asn Met Thr Cys 
    130                 135                 140                 


Thr Trp Asn Ala Gly Lys Leu Thr Tyr Ile Asp Thr Lys Tyr Val Val 
145                 150                 155                 160 


His Val Lys Ser Leu Glu Thr Glu Glu Glu Gln Gln Tyr Leu Thr Ser 
                165                 170                 175     


Ser Tyr Ile Asn Ile Ser Thr Asp Ser Leu Gln Gly Gly Lys Lys Tyr 
            180                 185                 190         


Leu Val Trp Val Gln Ala Ala Asn Ala Leu Gly Met Glu Glu Ser Lys 
        195                 200                 205             


Gln Leu Gln Ile His Leu Asp Asp Ile Val Ile Pro Ser Ala Ala Val 
    210                 215                 220                 


Ile Ser Arg Ala Glu Thr Ile Asn Ala Thr Val Pro Lys Thr Ile Ile 
225                 230                 235                 240 


Tyr Trp Asp Ser Gln Thr Thr Ile Glu Lys Val Ser Cys Glu Met Arg 
                245                 250                 255     


Tyr Lys Ala Thr Thr Asn Gln Thr Trp Asn Val Lys Glu Phe Asp Thr 
            260                 265                 270         


Asn Phe Thr Tyr Val Gln Gln Ser Glu Phe Tyr Leu Glu Pro Asn Ile 
        275                 280                 285             


Lys Tyr Val Phe Gln Val Arg Cys Gln Glu Thr Gly Lys Arg Tyr Trp 
    290                 295                 300                 


Gln Pro Trp Ser Ser Leu Phe Phe His Lys Thr Pro Glu Thr Val Pro 
305                 310                 315                 320 


Gln Val Thr Ser Lys Ala Phe Gln His Asp Thr Trp Asn Ser Gly Leu 
                325                 330                 335     


Thr Val Ala Ser Ile Ser Thr Gly His Leu Thr Ser Asp Asn Arg Gly 
            340                 345                 350         


Asp Ile Gly Leu Leu Leu Gly Met Ile Val Phe Ala Val Met Leu Ser 
        355                 360                 365             


Ile Leu Ser Leu Ile Gly Ile Phe Asn Arg Ser Phe Arg Thr Gly Ile 
    370                 375                 380                 


Lys Arg Arg Ile Leu Leu Leu Ile Pro Lys Trp Leu Tyr Glu Asp Ile 
385                 390                 395                 400 


Pro Asn Met Lys Asn Ser Asn Val Val Lys Met Leu Gln Glu Asn Ser 
                405                 410                 415     


Glu Leu Met Asn Asn Asn Ser Ser Glu Gln Val Leu Tyr Val Asp Pro 
            420                 425                 430         


Met Ile Thr Glu Ile Lys Glu Ile Phe Ile Pro Glu His Lys Pro Thr 
        435                 440                 445             


Asp Tyr Lys Lys Glu Asn Thr Gly Pro Leu Glu Thr Arg Asp Tyr Pro 
    450                 455                 460                 


Gln Asn Ser Leu Phe Asp Asn Thr Thr Val Val Tyr Ile Pro Asp Leu 
465                 470                 475                 480 


Asn Thr Gly Tyr Lys Pro Gln Ile Ser Asn Phe Leu Pro Glu Gly Ser 
                485                 490                 495     


His Leu Ser Asn Asn Asn Glu Ile Thr Ser Leu Thr Leu Lys Pro Pro 
            500                 505                 510         


Val Asp Ser Leu Asp Ser Gly Asn Asn Pro Arg Leu Gln Lys His Pro 
        515                 520                 525             


Asn Phe Ala Phe Ser Val Ser Ser Val Asn Ser Leu Ser Asn Thr Ile 
    530                 535                 540                 


Phe Leu Gly Glu Leu Ser Leu Ile Leu Asn Gln Gly Glu Cys Ser Ser 
545                 550                 555                 560 


Pro Asp Ile Gln Asn Ser Val Glu Glu Glu Thr Thr Met Leu Leu Glu 
                565                 570                 575     


Asn Asp Ser Pro Ser Glu Thr Ile Pro Glu Gln Thr Leu Leu Pro Asp 
            580                 585                 590         


Glu Phe Val Ser Cys Leu Gly Ile Val Asn Glu Glu Leu Pro Ser Ile 
        595                 600                 605             


Asn Thr Tyr Phe Pro Gln Asn Ile Leu Glu Ser His Phe Asn Arg Ile 
    610                 615                 620                 


Ser Leu Leu Glu Lys 
625                 

<210>  584
<211>  402
<212>  DNA
<213>  Homo sapiens

<400>  584
ctcattttct cttgccacca ctaagtaaga agagcctttt gcctcccacc atgattctga     60

ggccttacca gccatgtgga actgttaaag aatttgacac caattttaca tatgtgcaac    120

agtcagaatt ctacttggag ccaaacatta agtacgtatt tcaagtgaga tgtcaagaaa    180

caggcaaaag gtactggcag ccttggagtt cactgttttt tcataaaaca cctgaaacag    240

ttccccaggt cacatcaaaa gcattccaac atgacacatg gaattctggg ctaacagttg    300

cttccatctc tacagggcac cttacttctg gattaaaaga aggatcttat tgttaatacc    360

aaagtggctt tatgaagata ttcctaatat gaaaaacagc aa                       402


<210>  585
<211>  101
<212>  PRT
<213>  Homo sapiens

<400>  585


Met Ile Leu Arg Pro Tyr Gln Pro Cys Gly Thr Val Lys Glu Phe Asp 
1               5                   10                  15      


Thr Asn Phe Thr Tyr Val Gln Gln Ser Glu Phe Tyr Leu Glu Pro Asn 
            20                  25                  30          


Ile Lys Tyr Val Phe Gln Val Arg Cys Gln Glu Thr Gly Lys Arg Tyr 
        35                  40                  45              


Trp Gln Pro Trp Ser Ser Leu Phe Phe His Lys Thr Pro Glu Thr Val 
    50                  55                  60                  


Pro Gln Val Thr Ser Lys Ala Phe Gln His Asp Thr Trp Asn Ser Gly 
65                  70                  75                  80  


Leu Thr Val Ala Ser Ile Ser Thr Gly His Leu Thr Ser Gly Leu Lys 
                85                  90                  95      


Glu Gly Ser Tyr Cys 
            100     

<210>  586
<211>  1294
<212>  DNA
<213>  Homo sapiens

<400>  586
ctcattttct cttgccacca ctaagtaaga agagcctttt gcctcccacc atgattctga     60

ggccttacca gccatgtgga actgttaaag aatttgacac caattttaca tatgtgcaac    120

agtcagaatt ctacttggag ccaaacatta agtacgtatt tcaagtgaga tgtcaagaaa    180

caggcaaaag gtactggcag ccttggagtt cactgttttt tcataaaaca cctgaaacag    240

ttccccaggt cacatcaaaa gcattccaac atgacacatg gaattctggg ctaacagttg    300

cttccatctc tacagggcac cttacttctg acaacagagg agacattgga cttttattgg    360

gaatgatcgt ctttgctgtt atgttgtcaa ttctttcttt gattgggata tttaacagat    420

cattccgaac tgggattaaa agaaggatct tattgttaat accaaagtgg ctttatgaag    480

atattcctaa tatgaaaaac agcaatgttg tgaaaatgct acaggaaaat agtgaactta    540

tgaataataa ttccagtgag caggtcctat atgttgatcc catgattaca gagataaaag    600

aaatcttcat cccagaacac aagcctacag actacaagaa ggagaataca ggacccctgg    660

agacaagaga ctacccgcaa aactcgctat tcgacaatac tacagttgta tatattcctg    720

atctcaacac tggatataaa ccccaaattt caaattttct gcctgaggga agccatctca    780

gcaataataa tgaaattact tccttaacac ttaaaccacc agttgattcc ttagactcag    840

gaaataatcc caggttacaa aagcatccta attttgcttt ttctgtttca agtgtgaatt    900

cactaagcaa cacaatattt cttggagaat taagcctcat attaaatcaa ggagaatgca    960

gttctcctga catacaaaac tcagtagagg aggaaaccac catgcttttg gaaaatgatt   1020

cacccagtga aactattcca gaacagaccc tgcttcctga tgaatttgtc tcctgtttgg   1080

ggatcgtgaa tgaggagttg ccatctatta atacttattt tccacaaaat attttggaaa   1140

gccacttcaa taggatttca ctcttggaaa agtagagctg tgtggtcaaa atcaatatga   1200

gaaagctgcc ttgcaatctg aacttgggtt ttccctgcaa tagaaattga attctgcctc   1260

tttttgaaaa aaatgtattc acatacaaat cttc                               1294


<210>  587
<211>  374
<212>  PRT
<213>  Homo sapiens

<400>  587


Met Ile Leu Arg Pro Tyr Gln Pro Cys Gly Thr Val Lys Glu Phe Asp 
1               5                   10                  15      


Thr Asn Phe Thr Tyr Val Gln Gln Ser Glu Phe Tyr Leu Glu Pro Asn 
            20                  25                  30          


Ile Lys Tyr Val Phe Gln Val Arg Cys Gln Glu Thr Gly Lys Arg Tyr 
        35                  40                  45              


Trp Gln Pro Trp Ser Ser Leu Phe Phe His Lys Thr Pro Glu Thr Val 
    50                  55                  60                  


Pro Gln Val Thr Ser Lys Ala Phe Gln His Asp Thr Trp Asn Ser Gly 
65                  70                  75                  80  


Leu Thr Val Ala Ser Ile Ser Thr Gly His Leu Thr Ser Asp Asn Arg 
                85                  90                  95      


Gly Asp Ile Gly Leu Leu Leu Gly Met Ile Val Phe Ala Val Met Leu 
            100                 105                 110         


Ser Ile Leu Ser Leu Ile Gly Ile Phe Asn Arg Ser Phe Arg Thr Gly 
        115                 120                 125             


Ile Lys Arg Arg Ile Leu Leu Leu Ile Pro Lys Trp Leu Tyr Glu Asp 
    130                 135                 140                 


Ile Pro Asn Met Lys Asn Ser Asn Val Val Lys Met Leu Gln Glu Asn 
145                 150                 155                 160 


Ser Glu Leu Met Asn Asn Asn Ser Ser Glu Gln Val Leu Tyr Val Asp 
                165                 170                 175     


Pro Met Ile Thr Glu Ile Lys Glu Ile Phe Ile Pro Glu His Lys Pro 
            180                 185                 190         


Thr Asp Tyr Lys Lys Glu Asn Thr Gly Pro Leu Glu Thr Arg Asp Tyr 
        195                 200                 205             


Pro Gln Asn Ser Leu Phe Asp Asn Thr Thr Val Val Tyr Ile Pro Asp 
    210                 215                 220                 


Leu Asn Thr Gly Tyr Lys Pro Gln Ile Ser Asn Phe Leu Pro Glu Gly 
225                 230                 235                 240 


Ser His Leu Ser Asn Asn Asn Glu Ile Thr Ser Leu Thr Leu Lys Pro 
                245                 250                 255     


Pro Val Asp Ser Leu Asp Ser Gly Asn Asn Pro Arg Leu Gln Lys His 
            260                 265                 270         


Pro Asn Phe Ala Phe Ser Val Ser Ser Val Asn Ser Leu Ser Asn Thr 
        275                 280                 285             


Ile Phe Leu Gly Glu Leu Ser Leu Ile Leu Asn Gln Gly Glu Cys Ser 
    290                 295                 300                 


Ser Pro Asp Ile Gln Asn Ser Val Glu Glu Glu Thr Thr Met Leu Leu 
305                 310                 315                 320 


Glu Asn Asp Ser Pro Ser Glu Thr Ile Pro Glu Gln Thr Leu Leu Pro 
                325                 330                 335     


Asp Glu Phe Val Ser Cys Leu Gly Ile Val Asn Glu Glu Leu Pro Ser 
            340                 345                 350         


Ile Asn Thr Tyr Phe Pro Gln Asn Ile Leu Glu Ser His Phe Asn Arg 
        355                 360                 365             


Ile Ser Leu Leu Glu Lys 
    370                 

<210>  588
<211>  1537
<212>  DNA
<213>  Homo sapiens

<400>  588
ctcattttct cttgccacca ctaagtaaga agagcctttt gcctcccacc atgattctga     60

ggccttacca gccatgtgga actgttaaag aatttgacac caattttaca tatgtgcaac    120

agtcagaatt ctacttggag ccaaacatta agtacgtatt tcaagtgaga tgtcaagaaa    180

caggcaaaag gtactggcag ccttggagtt cactgttttt tcataaaaca cctgaaacag    240

ttccccaggt cacatcaaaa gcattccaac atgacacatg gaattctggg ctaacagttg    300

cttccatctc tacagggcac cttacttctg acaacagagg agacattgga cttttattgg    360

gaatgatcgt ctttgctgtt atgttgtcaa ttctttcttt gattgggata tttaacagat    420

cattccgaac tgggattaaa agaaggatct tattgttaat accaaagtgg ctttatgaag    480

atattcctaa tatgaaaaac agcaatgttg tgaaaatgct acaggaaaat agtgaactta    540

tgaataataa ttccagtgag caggtcctat atgttgatcc catgattaca gagataaaag    600

aaatcttcat cccagaacac aagcctacag actacaagaa ggagaataca ggacccctgg    660

agacaagaga ctacccgcaa aactcgctat tcgacaatac tacagttgta tatattcctg    720

atctcaacac tggatataaa ccccaaattt caaattttct gcctgaggga agccatctca    780

gcaataataa tgaaattact tccttaacac ttaaaccacc agttgattcc ttagactcag    840

gaaataatcc caggttacaa aagcatccta attttgcttt ttctgtttca agtgtgaatt    900

cactaagcaa cacaatattt cttggagaat taagcctcat attaaatcaa ggagaatgca    960

gttctcctga catacaaaac tcagtagagg aggaaaccac catgcttttg gaaaatgatt   1020

cacccagtga aactattcca gaacagaccc tgcttcctga tgaatttgtc tcctgtttgg   1080

ggatcgtgaa tgaggagttg ccatctatta atacttattt tccacaaaat attttggaaa   1140

gccacttcaa taggatttca ctcttggaaa agtagagctg tgtggtcaaa atcaatatga   1200

gaaagctgcc ttgcaatctg aacttgggtt ttccctgcaa tagaaattga attctgcctc   1260

tttttgaaaa aaatgtattc acatacaaat cttcacatgg acacatgttt tcatttccct   1320

tggataaata cctaggtagg ggattgctgg gccatatgat aagcatatgt ttcagttcta   1380

ccaatcttgt ttccagagta gtgacatttc tgtgctccta ccatcaccat gtaagaattc   1440

ccgggagctc catgcctttt taattttagc cattcttctg cctcatttct taaaattaga   1500

gaattaaggt cccgaaggtg gaacatgctt catggtc                            1537


<210>  589
<211>  374
<212>  PRT
<213>  Homo sapiens

<400>  589


Met Ile Leu Arg Pro Tyr Gln Pro Cys Gly Thr Val Lys Glu Phe Asp 
1               5                   10                  15      


Thr Asn Phe Thr Tyr Val Gln Gln Ser Glu Phe Tyr Leu Glu Pro Asn 
            20                  25                  30          


Ile Lys Tyr Val Phe Gln Val Arg Cys Gln Glu Thr Gly Lys Arg Tyr 
        35                  40                  45              


Trp Gln Pro Trp Ser Ser Leu Phe Phe His Lys Thr Pro Glu Thr Val 
    50                  55                  60                  


Pro Gln Val Thr Ser Lys Ala Phe Gln His Asp Thr Trp Asn Ser Gly 
65                  70                  75                  80  


Leu Thr Val Ala Ser Ile Ser Thr Gly His Leu Thr Ser Asp Asn Arg 
                85                  90                  95      


Gly Asp Ile Gly Leu Leu Leu Gly Met Ile Val Phe Ala Val Met Leu 
            100                 105                 110         


Ser Ile Leu Ser Leu Ile Gly Ile Phe Asn Arg Ser Phe Arg Thr Gly 
        115                 120                 125             


Ile Lys Arg Arg Ile Leu Leu Leu Ile Pro Lys Trp Leu Tyr Glu Asp 
    130                 135                 140                 


Ile Pro Asn Met Lys Asn Ser Asn Val Val Lys Met Leu Gln Glu Asn 
145                 150                 155                 160 


Ser Glu Leu Met Asn Asn Asn Ser Ser Glu Gln Val Leu Tyr Val Asp 
                165                 170                 175     


Pro Met Ile Thr Glu Ile Lys Glu Ile Phe Ile Pro Glu His Lys Pro 
            180                 185                 190         


Thr Asp Tyr Lys Lys Glu Asn Thr Gly Pro Leu Glu Thr Arg Asp Tyr 
        195                 200                 205             


Pro Gln Asn Ser Leu Phe Asp Asn Thr Thr Val Val Tyr Ile Pro Asp 
    210                 215                 220                 


Leu Asn Thr Gly Tyr Lys Pro Gln Ile Ser Asn Phe Leu Pro Glu Gly 
225                 230                 235                 240 


Ser His Leu Ser Asn Asn Asn Glu Ile Thr Ser Leu Thr Leu Lys Pro 
                245                 250                 255     


Pro Val Asp Ser Leu Asp Ser Gly Asn Asn Pro Arg Leu Gln Lys His 
            260                 265                 270         


Pro Asn Phe Ala Phe Ser Val Ser Ser Val Asn Ser Leu Ser Asn Thr 
        275                 280                 285             


Ile Phe Leu Gly Glu Leu Ser Leu Ile Leu Asn Gln Gly Glu Cys Ser 
    290                 295                 300                 


Ser Pro Asp Ile Gln Asn Ser Val Glu Glu Glu Thr Thr Met Leu Leu 
305                 310                 315                 320 


Glu Asn Asp Ser Pro Ser Glu Thr Ile Pro Glu Gln Thr Leu Leu Pro 
                325                 330                 335     


Asp Glu Phe Val Ser Cys Leu Gly Ile Val Asn Glu Glu Leu Pro Ser 
            340                 345                 350         


Ile Asn Thr Tyr Phe Pro Gln Asn Ile Leu Glu Ser His Phe Asn Arg 
        355                 360                 365             


Ile Ser Leu Leu Glu Lys 
    370                 

<210>  590
<211>  1498
<212>  DNA
<213>  Homo sapiens

<400>  590
aagtaagaag agccttttgc ctcccaccat gattctgagg ccttaccagc catgtggaac     60

tgttaaagaa tttgacacca attttacata tgtgcaacag tcagaattct acttggagcc    120

aaacattaag tacgtatttc aagtgagatg tcaagaaaca ggcaaaaggt actggcagcc    180

ttggagttca ctgttttttc ataaaacacc tgaaacagga ttaaaagaag gatcttattg    240

ttaataccaa agtggcttta tgaagatatt cctaatatga aaaacagcaa tgttgtgaaa    300

atgctacagg aaaatagtga acttatgaat aataattcca gtgagcaggt cctatatgtt    360

gatcccatga ttacagagat aaaagaaatc ttcatcccag aacacaagcc tacagactac    420

aagaaggaga atacaggacc cctggagaca agagactacc cgcaaaactc gctattcgac    480

aatactacag ttgtatatat tcctgatctc aacactggat ataaacccca aatttcaaat    540

tttctgcctg agggaagcca tctcagcaat aataatgaaa ttacttcctt aacacttaaa    600

ccaccagttg attccttaga ctcaggaaat aatcccaggt tacaaaagca tcctaatttt    660

gctttttctg tttcaagtgt gaattcacta agcaacacaa tatttcttgg agaattaagc    720

ctcatattaa atcaaggaga atgcagttct cctgacatac aaaactcagt agaggaggaa    780

accaccatgc ttttggaaaa tgattcaccc agtgaaacta ttccagaaca gaccctgctt    840

cctgatgaat ttgtctcctg tttggggatc gtgaatgagg agttgccatc tattaatact    900

tattttccac aaaatatttt ggaaagccac ttcaatagga tttcactctt ggaaaagtag    960

agctgtgtgg tcaaaatcaa tatgagaaag ctgccttgca atctgaactt gggttttccc   1020

tgcaatagaa attgaattct gcctcttttt gaaaaaaatg tattcacata caaatcttca   1080

catggacaca tgttttcatt tcccttggat aaatacctag gtaggggatt gctgggccat   1140

atgataagca tatgtttcag ttctaccaat cttgtttcca gagtagtgac atttctgtgc   1200

tcctaccatc accatgtaag aattcccggg agctccatgc ctttttaatt ttagccattc   1260

ttctgcctca tttcttaaaa ttagagaatt aaggtcccga aggtggaaca tgcttcatgg   1320

tcacacatac aggcacaaaa acagcattat gtggacgcct catgtatttt ttatagagtc   1380

aactatttcc tctttatttt ccctcattga aagatgcaaa acagctctct attgtgtaca   1440

gaaagggtaa ataatgcaaa atacctggta gtaaaataaa tgctgaaaat tttccttt     1498


<210>  591
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  591


Met Lys Asn Ser Asn Val Val Lys Met Leu Gln Glu Asn Ser Glu Leu 
1               5                   10                  15      


Met Asn Asn Asn Ser Ser Glu Gln Val Leu Tyr Val Asp Pro Met Ile 
            20                  25                  30          


Thr Glu Ile Lys Glu Ile Phe Ile Pro Glu His Lys Pro Thr Asp Tyr 
        35                  40                  45              


Lys Lys Glu Asn Thr Gly Pro Leu Glu Thr Arg Asp Tyr Pro Gln Asn 
    50                  55                  60                  


Ser Leu Phe Asp Asn Thr Thr Val Val Tyr Ile Pro Asp Leu Asn Thr 
65                  70                  75                  80  


Gly Tyr Lys Pro Gln Ile Ser Asn Phe Leu Pro Glu Gly Ser His Leu 
                85                  90                  95      


Ser Asn Asn Asn Glu Ile Thr Ser Leu Thr Leu Lys Pro Pro Val Asp 
            100                 105                 110         


Ser Leu Asp Ser Gly Asn Asn Pro Arg Leu Gln Lys His Pro Asn Phe 
        115                 120                 125             


Ala Phe Ser Val Ser Ser Val Asn Ser Leu Ser Asn Thr Ile Phe Leu 
    130                 135                 140                 


Gly Glu Leu Ser Leu Ile Leu Asn Gln Gly Glu Cys Ser Ser Pro Asp 
145                 150                 155                 160 


Ile Gln Asn Ser Val Glu Glu Glu Thr Thr Met Leu Leu Glu Asn Asp 
                165                 170                 175     


Ser Pro Ser Glu Thr Ile Pro Glu Gln Thr Leu Leu Pro Asp Glu Phe 
            180                 185                 190         


Val Ser Cys Leu Gly Ile Val Asn Glu Glu Leu Pro Ser Ile Asn Thr 
        195                 200                 205             


Tyr Phe Pro Gln Asn Ile Leu Glu Ser His Phe Asn Arg Ile Ser Leu 
    210                 215                 220                 


Leu Glu Lys 
225         

<210>  592
<211>  4053
<212>  DNA
<213>  Homo sapiens

<400>  592
aagagctggg cggtgcagag cacagagaaa ggacatctgc gaggaaagtt ccctgatggc     60

tgtcaacaaa gtgccacgtc tctatggctg tgaacgctga gcacacgatt ttatcgcgcc    120

tatcatatct tggtgcataa acgcacctca cctcggtcaa cccttgctcc gtcttatgag    180

acaggcttta ttatccgcat tttatatgag gggaaactga cggtggagag agaattatct    240

tgctcaaggc gacacagcag agcccacagg tggcagaatc ccacccgagc ccgcttcgac    300

ccgcggggtg gaaaccacgg gcgcccgccc ggctgcgctt ccagagctga actgagaagc    360

gagtcctctc cgccctgcgg ccaccgccca gccccgaccc ccgccccggc ccgatcctca    420

ctcgccgcca gctccccgcg cccaccccgg agttggtggc gcagaggcgg gaggcggagg    480

cgggagggcg ggcgctggca ccgggaacgc ccgagcgccg gcagagagcg cggagagcgc    540

gacacgtgcg gcccagagca ccggggccac ccggtccccg caggcccggg accgcgcccg    600

ctggcaggcg acacgtggaa gaatacggag ttctatacca gagttgattg ttgatggcac    660

atacttttag aggatgctca ttggcattta tgtttataat cacgtggctg ttgattaaag    720

caaaaataga tgcgtgcaag agaggcgatg tgactgtgaa gccttcccat gtaattttac    780

ttggatccac tgtcaatatt acatgctctt tgaagcccag acaaggctgc tttcactatt    840

ccagacgtaa caagttaatc ctgtacaagt ttgacagaag aatcaatttt caccatggcc    900

actccctcaa ttctcaagtc acaggtcttc cccttggtac aaccttgttt gtctgcaaac    960

tggcctgtat caatagtgat gaaattcaaa tatgtggagc agagatcttc gttggtgttg   1020

ctccagaaca gcctcaaaat ttatcctgca tacagaaggg agaacagggg actgtggcct   1080

gcacctggga aagaggacga gacacccact tatacactga gtatactcta cagctaagtg   1140

gaccaaaaaa tttaacctgg cagaagcaat gtaaagacat ttattgtgac tatttggact   1200

ttggaatcaa cctcacccct gaatcacctg aatccaattt cacagccaag gttactgctg   1260

tcaatagtct tggaagctcc tcttcacttc catccacatt cacattcttg gacatagtga   1320

ggcctcttcc tccgtgggac attagaatca aatttcaaaa ggcttctgtg agcagatgta   1380

ccctttattg gagagatgag ggactggtac tgcttaatcg actcagatat cggcccagta   1440

acagcaggct ctggaatatg gttaatgtta caaaggccaa aggaagacat gatttgctgg   1500

atctgaaacc atttacagaa tatgaatttc agatttcctc taagctacat ctttataagg   1560

gaagttggag tgattggagt gaatcattga gagcacaaac accagaagaa gagcctactg   1620

ggatgttaga tgtctggtac atgaaacggc acattgacta cagtagacaa cagatttctc   1680

ttttctggaa gaatctgagt gtctcagagg caagaggaaa aattctccac tatcaggtga   1740

ccttgcagga gctgacagga gggaaagcca tgacacagaa catcacagga cacacctcct   1800

ggaccacagt cattcctaga accggaaatt gggctgtggc tgtgtctgca gcaaattcaa   1860

aaggcagttc tctgcccact cgtattaaca taatgaacct gtgtgaggca gggttgctgg   1920

ctcctcgcca ggtctctgca aactcagagg gcatggacaa cattctggtg acttggcagc   1980

ctcccaggaa agatccctct gctgttcagg agtacgtggt ggaatggaga gagctccatc   2040

cagggggtga cacacaggtc cctctaaact ggctacggag tcgaccctac aatgtgtctg   2100

ctctgatttc agagaacata aaatcctaca tctgttatga aatccgtgtg tatgcactct   2160

caggggatca aggaggatgc agctccatcc tgggtaactc taagcacaaa gcaccactga   2220

gtggccccca cattaatgcc atcacagagg aaaaggggag cattttaatt tcatggaaca   2280

gcattccagt ccaggagcaa atgggctgcc tcctccatta taggatatac tggaaggaac   2340

gggactccaa ctcccagcct cagctctgtg aaattcccta cagagtctcc caaaattcac   2400

atccaataaa cagcctgcag ccccgagtga catatgtcct gtggatgaca gctctgacag   2460

ctgctggtga aagttcccac ggaaatgaga gggaattttg tctgcaaggt aaagccaatt   2520

ggatggcgtt tgtggcacca agcatttgca ttgctatcat catggtgggc attttctcaa   2580

cgcattactt ccagcaaaag gtgtttgttc tcctagcagc cctcagacct cagtggtgta   2640

gcagagaaat tccagatcca gcaaatagca cttgcgctaa gaaatatccc attgcagagg   2700

agaagacaca gctgcccttg gacaggctcc tgatagactg gcccacgcct gaagatcctg   2760

aaccgctggt catcagtgaa gtccttcatc aagtgacccc agttttcaga catcccccct   2820

gctccaactg gccacaaagg gaaaaaggaa tccaaggtca tcaggcctct gagaaagaca   2880

tgatgcacag tgcctcaagc ccaccacctc caagagctct ccaagctgag agcagacaac   2940

tggtggatct gtacaaggtg ctggagagca ggggctccga cccaaagccc gaaaacccag   3000

cctgtccctg gacggtgctc ccagcaggtg accttcccac ccatgatggc tacttaccct   3060

ccaacataga tgacctcccc tcacatgagg cacctctcgc tgactctctg gaagaactgg   3120

agcctcagca catctccctt tctgttttcc cctcaagttc tcttcaccca ctcaccttct   3180

cctgtggtga taagctgact ctggatcagt taaagatgag gtgtgactcc ctcatgctct   3240

gagtggtgag gcttcaagcc ttaaagtcag tgtgccctca accagcacag cctgccccaa   3300

ttcccccagc ccctgctcca gcagctgtca tctctgggtg ccaccatcgg tctggctgca   3360

gctagaggac aggcaagcca gctctggggg agtcttagga actgggagtt ggtcttcact   3420

cagatgcctc atcttgcctt tcccagggcc ttaaaattac atccttcact gtgtggacct   3480

agagactcca acttgaattc ctagtaactt tcttggtatg ctggccagaa agggaaatga   3540

ggaggagagt agaaaccaca gctcttagta gtaatggcat acagtctaga ggaccattca   3600

tgcaatgact atttctaaag cacctgctac acagcaggct gtacacagca gatcagtact   3660

gttcaacaga acttcctgag atgatggaaa tgttctacct ctgcactcac tgtccagtac   3720

attagacact aggcacattg gctgttaatc acttggaatg tgtttagctt gactgaggaa   3780

ttaaattttg attgtaaatt taaatcgcca cacatggcta gtggctactg tattggagtg   3840

cacagctcta gatggctcct agattattga gagccttcaa aacaaatcaa cctagttcta   3900

tagatgaaga cataaaagac actggtaaac accaaggtaa aagggccccc aaggtggtca   3960

tgactggtct catttgcaga agtctaagaa tgtacctttt tctggccggg cgtggtagct   4020

catgcctgta atcccagcac tttgggaggc tga                                4053


<210>  593
<211>  862
<212>  PRT
<213>  Homo sapiens

<400>  593


Met Ala His Thr Phe Arg Gly Cys Ser Leu Ala Phe Met Phe Ile Ile 
1               5                   10                  15      


Thr Trp Leu Leu Ile Lys Ala Lys Ile Asp Ala Cys Lys Arg Gly Asp 
            20                  25                  30          


Val Thr Val Lys Pro Ser His Val Ile Leu Leu Gly Ser Thr Val Asn 
        35                  40                  45              


Ile Thr Cys Ser Leu Lys Pro Arg Gln Gly Cys Phe His Tyr Ser Arg 
    50                  55                  60                  


Arg Asn Lys Leu Ile Leu Tyr Lys Phe Asp Arg Arg Ile Asn Phe His 
65                  70                  75                  80  


His Gly His Ser Leu Asn Ser Gln Val Thr Gly Leu Pro Leu Gly Thr 
                85                  90                  95      


Thr Leu Phe Val Cys Lys Leu Ala Cys Ile Asn Ser Asp Glu Ile Gln 
            100                 105                 110         


Ile Cys Gly Ala Glu Ile Phe Val Gly Val Ala Pro Glu Gln Pro Gln 
        115                 120                 125             


Asn Leu Ser Cys Ile Gln Lys Gly Glu Gln Gly Thr Val Ala Cys Thr 
    130                 135                 140                 


Trp Glu Arg Gly Arg Asp Thr His Leu Tyr Thr Glu Tyr Thr Leu Gln 
145                 150                 155                 160 


Leu Ser Gly Pro Lys Asn Leu Thr Trp Gln Lys Gln Cys Lys Asp Ile 
                165                 170                 175     


Tyr Cys Asp Tyr Leu Asp Phe Gly Ile Asn Leu Thr Pro Glu Ser Pro 
            180                 185                 190         


Glu Ser Asn Phe Thr Ala Lys Val Thr Ala Val Asn Ser Leu Gly Ser 
        195                 200                 205             


Ser Ser Ser Leu Pro Ser Thr Phe Thr Phe Leu Asp Ile Val Arg Pro 
    210                 215                 220                 


Leu Pro Pro Trp Asp Ile Arg Ile Lys Phe Gln Lys Ala Ser Val Ser 
225                 230                 235                 240 


Arg Cys Thr Leu Tyr Trp Arg Asp Glu Gly Leu Val Leu Leu Asn Arg 
                245                 250                 255     


Leu Arg Tyr Arg Pro Ser Asn Ser Arg Leu Trp Asn Met Val Asn Val 
            260                 265                 270         


Thr Lys Ala Lys Gly Arg His Asp Leu Leu Asp Leu Lys Pro Phe Thr 
        275                 280                 285             


Glu Tyr Glu Phe Gln Ile Ser Ser Lys Leu His Leu Tyr Lys Gly Ser 
    290                 295                 300                 


Trp Ser Asp Trp Ser Glu Ser Leu Arg Ala Gln Thr Pro Glu Glu Glu 
305                 310                 315                 320 


Pro Thr Gly Met Leu Asp Val Trp Tyr Met Lys Arg His Ile Asp Tyr 
                325                 330                 335     


Ser Arg Gln Gln Ile Ser Leu Phe Trp Lys Asn Leu Ser Val Ser Glu 
            340                 345                 350         


Ala Arg Gly Lys Ile Leu His Tyr Gln Val Thr Leu Gln Glu Leu Thr 
        355                 360                 365             


Gly Gly Lys Ala Met Thr Gln Asn Ile Thr Gly His Thr Ser Trp Thr 
    370                 375                 380                 


Thr Val Ile Pro Arg Thr Gly Asn Trp Ala Val Ala Val Ser Ala Ala 
385                 390                 395                 400 


Asn Ser Lys Gly Ser Ser Leu Pro Thr Arg Ile Asn Ile Met Asn Leu 
                405                 410                 415     


Cys Glu Ala Gly Leu Leu Ala Pro Arg Gln Val Ser Ala Asn Ser Glu 
            420                 425                 430         


Gly Met Asp Asn Ile Leu Val Thr Trp Gln Pro Pro Arg Lys Asp Pro 
        435                 440                 445             


Ser Ala Val Gln Glu Tyr Val Val Glu Trp Arg Glu Leu His Pro Gly 
    450                 455                 460                 


Gly Asp Thr Gln Val Pro Leu Asn Trp Leu Arg Ser Arg Pro Tyr Asn 
465                 470                 475                 480 


Val Ser Ala Leu Ile Ser Glu Asn Ile Lys Ser Tyr Ile Cys Tyr Glu 
                485                 490                 495     


Ile Arg Val Tyr Ala Leu Ser Gly Asp Gln Gly Gly Cys Ser Ser Ile 
            500                 505                 510         


Leu Gly Asn Ser Lys His Lys Ala Pro Leu Ser Gly Pro His Ile Asn 
        515                 520                 525             


Ala Ile Thr Glu Glu Lys Gly Ser Ile Leu Ile Ser Trp Asn Ser Ile 
    530                 535                 540                 


Pro Val Gln Glu Gln Met Gly Cys Leu Leu His Tyr Arg Ile Tyr Trp 
545                 550                 555                 560 


Lys Glu Arg Asp Ser Asn Ser Gln Pro Gln Leu Cys Glu Ile Pro Tyr 
                565                 570                 575     


Arg Val Ser Gln Asn Ser His Pro Ile Asn Ser Leu Gln Pro Arg Val 
            580                 585                 590         


Thr Tyr Val Leu Trp Met Thr Ala Leu Thr Ala Ala Gly Glu Ser Ser 
        595                 600                 605             


His Gly Asn Glu Arg Glu Phe Cys Leu Gln Gly Lys Ala Asn Trp Met 
    610                 615                 620                 


Ala Phe Val Ala Pro Ser Ile Cys Ile Ala Ile Ile Met Val Gly Ile 
625                 630                 635                 640 


Phe Ser Thr His Tyr Phe Gln Gln Lys Val Phe Val Leu Leu Ala Ala 
                645                 650                 655     


Leu Arg Pro Gln Trp Cys Ser Arg Glu Ile Pro Asp Pro Ala Asn Ser 
            660                 665                 670         


Thr Cys Ala Lys Lys Tyr Pro Ile Ala Glu Glu Lys Thr Gln Leu Pro 
        675                 680                 685             


Leu Asp Arg Leu Leu Ile Asp Trp Pro Thr Pro Glu Asp Pro Glu Pro 
    690                 695                 700                 


Leu Val Ile Ser Glu Val Leu His Gln Val Thr Pro Val Phe Arg His 
705                 710                 715                 720 


Pro Pro Cys Ser Asn Trp Pro Gln Arg Glu Lys Gly Ile Gln Gly His 
                725                 730                 735     


Gln Ala Ser Glu Lys Asp Met Met His Ser Ala Ser Ser Pro Pro Pro 
            740                 745                 750         


Pro Arg Ala Leu Gln Ala Glu Ser Arg Gln Leu Val Asp Leu Tyr Lys 
        755                 760                 765             


Val Leu Glu Ser Arg Gly Ser Asp Pro Lys Pro Glu Asn Pro Ala Cys 
    770                 775                 780                 


Pro Trp Thr Val Leu Pro Ala Gly Asp Leu Pro Thr His Asp Gly Tyr 
785                 790                 795                 800 


Leu Pro Ser Asn Ile Asp Asp Leu Pro Ser His Glu Ala Pro Leu Ala 
                805                 810                 815     


Asp Ser Leu Glu Glu Leu Glu Pro Gln His Ile Ser Leu Ser Val Phe 
            820                 825                 830         


Pro Ser Ser Ser Leu His Pro Leu Thr Phe Ser Cys Gly Asp Lys Leu 
        835                 840                 845             


Thr Leu Asp Gln Leu Lys Met Arg Cys Asp Ser Leu Met Leu 
    850                 855                 860         

<210>  594
<211>  529
<212>  DNA
<213>  Homo sapiens

<400>  594
aaggggagca ttttaatttc atggaacagc attccagtcc aggagcaaat gggctgcctc     60

ctccattata ggatatactg gaaggaacgg gactccaact cccagcctca gctctgtgaa    120

attccctaca gagtctccca aaattcacat ccaataaaca gcctgcagcc ccgagtgaca    180

tatgtcctgt ggatgacagc tctgacagct gctggtgaaa gttcccacgg aaatgagagg    240

gaattttgtc tgcaaggtaa agccaattgg atggcgtttg tggcaccaag catttgcatt    300

gctatcatca tggtgggcat tttctcaacg cattacttcc agcaaaagag aagacacagc    360

tgcccttgga caggctcctg atagactggc ccacgcctga agatcctgaa ccgctggtca    420

tcagtgaagt ccttcatcaa gtgaccccag ttttcagaca tcccccctgc tccaactggc    480

cacaaaggga aaaaggaatc caaggtcatc aggcctctga gaaagacat                529


<210>  595
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  595


Met Gly Cys Leu Leu His Tyr Arg Ile Tyr Trp Lys Glu Arg Asp Ser 
1               5                   10                  15      


Asn Ser Gln Pro Gln Leu Cys Glu Ile Pro Tyr Arg Val Ser Gln Asn 
            20                  25                  30          


Ser His Pro Ile Asn Ser Leu Gln Pro Arg Val Thr Tyr Val Leu Trp 
        35                  40                  45              


Met Thr Ala Leu Thr Ala Ala Gly Glu Ser Ser His Gly Asn Glu Arg 
    50                  55                  60                  


Glu Phe Cys Leu Gln Gly Lys Ala Asn Trp Met Ala Phe Val Ala Pro 
65                  70                  75                  80  


Ser Ile Cys Ile Ala Ile Ile Met Val Gly Ile Phe Ser Thr His Tyr 
                85                  90                  95      


Phe Gln Gln Lys Arg Arg His Ser Cys Pro Trp Thr Gly Ser 
            100                 105                 110 

<210>  596
<211>  604
<212>  DNA
<213>  Homo sapiens

<400>  596
cctacattaa aagccatatc ctttaataca tgcctttctt cctttatctt cctttcagaa     60

attccctaca gagtctccca aaattcacat ccaataaaca gcctgcagcc ccgagtgaca    120

tatgtcctgt ggatgacagc tctgacagct gctggtgaaa gttcccacgg aaatgagagg    180

gaattttgtc tgcaaggtaa agccaattgg atggcgtttg tggcaccaag catttgcatt    240

gctatcatca tggtgggcat tttctcaacg cattacttcc agcaaaaggt gtttgttctc    300

ctagcagccc tcagacctca gtggtgtagc agagaaattc cagatccagc aaatagcact    360

tgcgctaaga aatatcccat tgcagaggag aagacacagc tgcccttgga caggctcctg    420

atagactggc ccacgcctga agatcctgaa ccgctggtca tcagtgaagt ccttcatcaa    480

gtgaccccag ttttcagaca tcccccctgc tccaactggc cacaaaggga aaaaggaatc    540

caaggtcatc aggcctctga gaaagacatg atgcacagtg cctcaagccc accacctcca    600

agag                                                                 604


<210>  597
<211>  156
<212>  PRT
<213>  Homo sapiens

<400>  597


Met Thr Ala Leu Thr Ala Ala Gly Glu Ser Ser His Gly Asn Glu Arg 
1               5                   10                  15      


Glu Phe Cys Leu Gln Gly Lys Ala Asn Trp Met Ala Phe Val Ala Pro 
            20                  25                  30          


Ser Ile Cys Ile Ala Ile Ile Met Val Gly Ile Phe Ser Thr His Tyr 
        35                  40                  45              


Phe Gln Gln Lys Val Phe Val Leu Leu Ala Ala Leu Arg Pro Gln Trp 
    50                  55                  60                  


Cys Ser Arg Glu Ile Pro Asp Pro Ala Asn Ser Thr Cys Ala Lys Lys 
65                  70                  75                  80  


Tyr Pro Ile Ala Glu Glu Lys Thr Gln Leu Pro Leu Asp Arg Leu Leu 
                85                  90                  95      


Ile Asp Trp Pro Thr Pro Glu Asp Pro Glu Pro Leu Val Ile Ser Glu 
            100                 105                 110         


Val Leu His Gln Val Thr Pro Val Phe Arg His Pro Pro Cys Ser Asn 
        115                 120                 125             


Trp Pro Gln Arg Glu Lys Gly Ile Gln Gly His Gln Ala Ser Glu Lys 
    130                 135                 140                 


Asp Met Met His Ser Ala Ser Ser Pro Pro Pro Pro 
145                 150                 155     

<210>  598
<211>  851
<212>  DNA
<213>  Homo sapiens

<400>  598
ttaacaccta tagttctctc aggctttttt tgaaaagttc cttcgtttct atttctattc     60

cactctattt agctattatt gtgcggcacc cccaatggtt cctttcctct cagcatcgct    120

gtagcttgcc tgtacccagg acatgccctt gactggcaca aaccgtgaca gacatgccct    180

tgactggcac aaaccatgac agacaaggcc acctcctcag aagcggaaca acctattatc    240

ttttggcaat gggagctaac ttcactgttt tcttacaata cctggttttt cctatctttg    300

gtttcctttt gattatctct catccatctc agccactatt ctcctcccct cccttgtgtc    360

tacaacaccc cattttacca agtctcccat ttaacctccc catccttttc tttcccttaa    420

agtctcatat gatactgcag tcctcatttg tcttcccaaa aaaaaaaaag aatttttttt    480

tttttaagga atccttcctt gactcctaaa gactcctaag gatgctgagg cctcctcagc    540

atgatttcca tatacaaagt aagcatcaca gcaccattgt gatgcatgga ggggtgtttc    600

tcattttaaa gacgtatttg agcatgtctt tggcagctca ctctgccaga taaggtgtcc    660

tctttccatg aatgacagaa gatgggtaac tctgttctgc cattgcccca agcggttttc    720

acaatctgcc cttctcccct ctgcccccca ccactagtaa aaaccccaaa ccaagttgct    780

aggttcacca gatctaggtg atactcacca acatacagct aggctttcat tcctcaggaa    840

aattgcaatt t                                                         851


<210>  599
<211>  43
<212>  PRT
<213>  Homo sapiens

<400>  599


Met Leu Arg Pro Pro Gln His Asp Phe His Ile Gln Ser Lys His His 
1               5                   10                  15      


Ser Thr Ile Val Met His Gly Gly Val Phe Leu Ile Leu Lys Thr Tyr 
            20                  25                  30          


Leu Ser Met Ser Leu Ala Ala His Ser Ala Arg 
        35                  40              

<210>  600
<211>  7030
<212>  DNA
<213>  Homo sapiens

<400>  600
gttagccctg agcccgaggg ggcgtgagtg aaaccaaaga gcactttcgc gagtcagtta     60

cgccgtcacg gttttttggt ttcaaggtag ctgaagacct agagagttta agggtggcca    120

gagcaggtgg caggactccg cccaccacca cgcttccctt ccttcagccc gcacgcttca    180

ctcccctcat ggggtctcgc ctctcaggcg cgcgcgaaga gttgtcgcgc ggtgcgtcct    240

gggaattgta gtcccgacgc ggagagtcgc ctcaggagaa atgactctgg cctacatacc    300

ccacagtgcc ttgcggcgca ggccgctccc ggatgtgtgc ctggcgccgg aagagaagac    360

ggcccccctc tctcggcccg gccatcttgt gggaagagct gaagcaggcg ctcttggctc    420

ggcgcggccc gctgcaatcc gtggaggaac gcgccgccga gccaccatca tgcctgggca    480

cttacaggaa ggcttcggct gcgtggtcac caaccgattc gaccagttat ttgacgacga    540

atcggacccc ttcgaggtgc tgaaggcagc agagaacaag aaaaaagaag ccggcggggg    600

cggcgttggg ggccctgggg ccaagagcgc agctcaggcc gcggcccaga ccaactccaa    660

cgcggcaggc aaacagctgc gcaaggagtc ccagaaagac cgcaagaacc cgctgccccc    720

cagcgttggc gtggttgaca agaaagagga gacgcagccg cccgtggcgc ttaagaaaga    780

aggaataaga cgagttggaa gaagacctga tcaacaactt cagggtgaag ggaaaataat    840

tgatagaaga ccagaaaggc gaccacctcg tgaacgaaga ttcgaaaagc cacttgaaga    900

aaagggtgaa ggaggcgaat tttcagttga tagaccgatt attgaccgac ctattcgagg    960

tcgtggtggt cttggaagag gtcgaggggg ccgtggacgt ggaatgggcc gaggagatgg   1020

atttgattct cgtggcaaac gtgaatttga taggcatagt ggaagtgata gatctggcct   1080

gaagcacgag gacaaacgtg gaggtagcgg atctcacaac tggggaactg tcaaagacga   1140

attaactgac ttggatcaat caaatgtgac tgaggaaaca cctgaaggtg aagaacatca   1200

tccagtggca gacactgaaa ataaggagaa tgaagttgaa gaggtaaaag aggagggtcc   1260

aaaagagatg actttggatg agtggaaggc tattcaaaat aaggaccggg caaaagtaga   1320

atttaatatc cgaaaaccaa atgaaggtgc tgatgggcag tggaagaagg gatttgttct   1380

tcataaatca aagagtgaag aggctcatgc tgaagattcg gttatggacc atcatttccg   1440

gaagccagca aatgatataa cgtctcagct ggagatcaat tttggagacc ttggccgccc   1500

aggacgtggc ggcaggggag gacgaggtgg acgtgggcgt ggtgggcgcc caaaccgtgg   1560

cagcaggacc gacaagtcaa gtgcttctgc tcctgatgtg gatgacccag aggcattccc   1620

agctctggct taactggatg ccataagaca accctggttc ctttgtgaac ccttctgttc   1680

aaagcttttg catgcttaag gattccaaac gactaagaaa ttaaaaaaaa aaagactgtc   1740

attcatacca ttcacaccta aagactgaat tttatctgtt ttaaaaatga acttctcccg   1800

ctacacagaa gtaacaaata tggtagtcag ttttgtattt agaaatgtat tggtagcagg   1860

gatgttttca taattttcag agattatgca ttcttcatga atacttttgt attgctgctt   1920

gcaaatatgc atttccaaac ttgaaatata ggtgtgaaca gtgtgtacca gtttaaagct   1980

ttcacttcat ttgtgttttt taattaagga tttagaagtt cccccaatta caaactggtt   2040

ttaaatattg gacatactgg ttttaatacc tgctttgcat attcacacat ggtcaactgg   2100

gacatgttaa actttgattt gtcaaatttt atgctgtgtg gaatactaac tatatgtatt   2160

ttaacttagt tttaatattt tcatttttgg ggaaaaatct tttttcactt ctcatgatag   2220

ctgttatata tatatgctaa atctttatat acagaaatat cagtacttga acaaattcaa   2280

agcacatttg gtttattaac ccttgctcct tgcatggctc attaggttca aattataact   2340

gatttacatt ttcagctata tttacttttt aaatgcttga gtttcccatt ttaaaatcta   2400

aactagacat cttaattggt gaaagttgtt taaactactt attgttggta ggcacatcgt   2460

gtcaagtgaa gtagttttat aggtatgggt tttttctccc ccttcaccag ggtgggtgga   2520

ataagttgat ttggccaatg tgtaatattt aaactgttct gtaaaataag tgtctggcca   2580

tttggtatga tttctgtgtg tgaaaggtcc caaaatcaaa atggtacatc cataatcagc   2640

caccatttaa cccttccttg ttctaaaaca aaaaccaaag ggcgctggtt ggtagggtga   2700

ggtgggggag tattttaatt tttggaattt gggaagcaga cagctttact ttgtaaggtt   2760

ggaacagcag cactatacat gaaatataaa ccaaaaacct ttactgtttc taaatttcct   2820

agattgctat tatttggttg taagttgagt attccacaga aagtggtaat tatctcttct   2880

ctcttcctcc attagaaaat taggtaaata atggattcct ataatgggag catcaccact   2940

tattaaaaca cacatagaat gatgaattaa aaaagttttc taggattgtc ttttattctg   3000

ccacatttat tgataaacag tgaaggaatt tttaaaaaat ttttaagaat tgtttgtcac   3060

gtcattttta gaaatgttct acctgtatat ggtaatgtcc agttttaaaa atattggaca   3120

tcttcaatct taaacatttc tatttagctg attggttctc acatatactt ctaaaagaaa   3180

cttttatgtt ataagagtta ctttttggat aagatttatt aatctcagtt acctactatt   3240

ctgacatttt aggaaggagg taattgtttt taatgatgga taaacttgtg ctggtgtttt   3300

ggatcttatg atgctgagca tgttctgcac tggtgctaat gtctaatata attttatatt   3360

tacacacata cgtgctaccc agagattaat ttagtccata tgaactattg acccattgtt   3420

cattgagaca gcaacatacg cactcctaaa tcagtgtgtt tagacttttc aagtatctaa   3480

ctcatttcca aacatgtacc atgttttata aacctcttga tttccagcaa catactatag   3540

aaaacacctg ctactcaaaa cacaacttct cagtgtcatc cattgctgtc gtgagagaca   3600

acatagcaat atctggtatg ttgcaagctt tcaagatagc ctgaacttaa aaagttggtg   3660

cattagttgt atctgatgga tataaatttg cctcctagtt cactttgtgt caagagctaa   3720

aactgtgaac ctaactttct cttattggtg ggtaataact gaaaataaag atttattttc   3780

atgctcactt cttaaaagtc ataaaaacaa tcaaatagga tcatgtttat tgtcatgtgt   3840

ttcctggttt ctgacctgtg tgcacacccc tgtgtgttta taatttttaa attgaatttt   3900

atatggggtt tttatttgct aaaaaccagg ctgttgaatc acatttggga agggtactta   3960

tcttaatgac taatgactta attgggaaag ttgaattctt gtaaaataca aaatccaagg   4020

acttcttgga tttaatctga ttgtcacttc ttagcagatc acttttttga taatgaaagt   4080

taagcatact gaatgctact tttgattgac aaactggcta taatagtcta ggggaaaaat   4140

ccctaaacag ataaagattc ctaaagtaat ggtggcagct gatgtttcag tgaactttta   4200

tcttgatgcg tttaaatgga agtaatgcca gacctgagat ttttaaggca tttttacagc   4260

ttgtattgaa atgattggag acatggtttc tttattagct attttgagac ctgtggagtt   4320

aagcaagact tttaaaaatt ggcaccatat acatctagtt agttccttta ctcttatttt   4380

tttaaataaa agtagtacac atcatttcca gggttgtaaa tatatttggg gcttgttttt   4440

ggtatggatt taaaaggagg atattaagta ttcattctaa ttttgttatt tttctagttg   4500

ccagagatgg ttgcactgaa atagaacagg gagttgcata caaagcctaa atgtgtattg   4560

gatttcgaaa atactaggtt ggtgcaattg gttttgtacc aacctaacat gtctttagga   4620

aagtaccatc atgtggaagg aaacaacagg tgttaaaagg ttcaaaggaa tgagaaatag   4680

gaagttacta gaacctaact gatgttgacc ttagaggtaa gattattcag gtatattagt   4740

ggacctccag tccaatggta tagcaaattc cagggatctc aggtgcatgc aattttactt   4800

tctaaagtaa acacttagaa aatagattat aacccagacg ttttggatta tactgagaca   4860

aatatgtaaa taagttttag caagtctgaa catgtaccag cgagatcttc aggttaacta   4920

agaaaagccc agaaacttca ttatttactg tgctttgtat ggcataactg gtaacaaggc   4980

agtaaaatga tacatatttg aactggacca tagtaattaa atgatttatc aatatcattt   5040

gcaagataat tgtcaggttg agttaatagt aagtggcagc ttcccagaaa tttgggttat   5100

ttggcctaag ctgtgccctg ggattacctc ttcatcttcc ttgactttta agttcaaatt   5160

tggaggttat gtgaagtgat tgaaataaat ctttcaggct gaggaagtcg gtaatttcaa   5220

gaatatagtg aaaacaaggt tgtaatctaa acatgagaag cttaagttta ggaaatggtt   5280

agaatataaa ttgctaaagc catcatgatt ttggccacag atgaaaatat gaacactgga   5340

aatgagcgcc atttaaatga gatgctgtat gtaagccagg ggtcagcaaa gttcagcctg   5400

tgacctggtg tgtgtggggg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtccgtgtc   5460

cctgagttaa gaatggtttt taggcttgta taggattaaa aaaaaaaaaa acccacagaa   5520

aaatgtaggc agcccagcat aagataccgc ctttcacaga aatgtttgct gaccccggaa   5580

ctgtcactct cgggttacaa gagtttgttt ctttgaaaca gtctggctct gtcacccagg   5640

ctggagtgca gtggcatgat ctcaggtcac tgcagcctcc acctcccggg ttcaagcaat   5700

tctgcctcag cctcctgagt agctgggatt acaggtgtgc accaccacag acagctaatt   5760

ttacaggtgt acaccaccac acccaagaat cacttgaacc cgggaggtgg gggttgcagt   5820

gagccaagat catagcactg tactccagtc tgggtgacac actgtctgaa aaataaaagt   5880

ttagttctag gtacaaatta agtggtctac ccaacaggaa gctgtgaaat tagaagtaat   5940

tttaaagcat actttacacc tctatataat caaagtaagg gcaagataaa acttgttagt   6000

aaaacatgtt ttattatttt ttagataggt agcctgcaac ataaaatata ttttgaaagc   6060

tgttaagggg tgtataatct gttaaaaaat accatgatta gtatttcaca tttagtgact   6120

cagatccctt tgtgtaagtc ctttgcgttg tgcaaagagg tttttctatg agatgagaat   6180

tatgaacact tcatataggt aaattccata ggttgagctg gggcagaaat taatggctcc   6240

tggagattgc atcttttttt tttttttttt gagcttagaa ttcccatttg gacagaattt   6300

agcttttgtg ctgttgatta cttctgtact aaactggtag ccaattgttc acttctaaat   6360

ggaagggaaa aagttaccca cacaagttag aaaatgattt accgaattat ttttttgagt   6420

tagtatgtat atactgtttt aaatcagtaa tgtttgttcc ttttgctgcc catttgggag   6480

tatgtggcaa ttcctagtgc tcttgtatga cattactctt cttgagactt gtatatgcaa   6540

gaaagtatat ataaaagatg cctggtggta actttgtatc tgagttctga ttcattatgg   6600

acttttagaa atctatttag ataattggtt catactaggt gctcaattac tctgaccttg   6660

tgtggcttaa tccttaaata gttgctttag gtgttactgg gtggaagcat ggaaagtgaa   6720

gggctaatat taaggatttt tatgtattac tgagtaggga aagtgggaag tagcttatct   6780

ttggacagtt gtattacttt gcactaatca ccttgtttgc agttgtagct gattcagttc   6840

tagattttag gaccaaaaag atctctaatt taaagaaaca gtttttatat acctagaatg   6900

aagattctgt ttaaagcggt tttggttaac ttggttcttg acatttgcct aaaattttgt   6960

tggattggga ctaaaatgtt ctattagcca atgaataacg tccaagtaaa tttttgtttt   7020

attttgggaa                                                          7030


<210>  601
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  601


Met Thr Leu Ala Tyr Ile Pro His Ser Ala Leu Arg Arg Arg Pro Leu 
1               5                   10                  15      


Pro Asp Val Cys Leu Ala Pro Glu Glu Lys Thr Ala Pro Leu Ser Arg 
            20                  25                  30          


Pro Gly His Leu Val Gly Arg Ala Glu Ala Gly Ala Leu Gly Ser Ala 
        35                  40                  45              


Arg Pro Ala Ala Ile Arg Gly Gly Thr Arg Arg Arg Ala Thr Ile Met 
    50                  55                  60                  


Pro Gly His Leu Gln Glu Gly Phe Gly Cys Val Val Thr Asn Arg Phe 
65                  70                  75                  80  


Asp Gln Leu Phe Asp Asp Glu Ser Asp Pro Phe Glu Val Leu Lys Ala 
                85                  90                  95      


Ala Glu Asn Lys Lys Lys Glu Ala Gly Gly Gly Gly Val Gly Gly Pro 
            100                 105                 110         


Gly Ala Lys Ser Ala Ala Gln Ala Ala Ala Gln Thr Asn Ser Asn Ala 
        115                 120                 125             


Ala Gly Lys Gln Leu Arg Lys Glu Ser Gln Lys Asp Arg Lys Asn Pro 
    130                 135                 140                 


Leu Pro Pro Ser Val Gly Val Val Asp Lys Lys Glu Glu Thr Gln Pro 
145                 150                 155                 160 


Pro Val Ala Leu Lys Lys Glu Gly Ile Arg Arg Val Gly Arg Arg Pro 
                165                 170                 175     


Asp Gln Gln Leu Gln Gly Glu Gly Lys Ile Ile Asp Arg Arg Pro Glu 
            180                 185                 190         


Arg Arg Pro Pro Arg Glu Arg Arg Phe Glu Lys Pro Leu Glu Glu Lys 
        195                 200                 205             


Gly Glu Gly Gly Glu Phe Ser Val Asp Arg Pro Ile Ile Asp Arg Pro 
    210                 215                 220                 


Ile Arg Gly Arg Gly Gly Leu Gly Arg Gly Arg Gly Gly Arg Gly Arg 
225                 230                 235                 240 


Gly Met Gly Arg Gly Asp Gly Phe Asp Ser Arg Gly Lys Arg Glu Phe 
                245                 250                 255     


Asp Arg His Ser Gly Ser Asp Arg Ser Gly Leu Lys His Glu Asp Lys 
            260                 265                 270         


Arg Gly Gly Ser Gly Ser His Asn Trp Gly Thr Val Lys Asp Glu Leu 
        275                 280                 285             


Thr Asp Leu Asp Gln Ser Asn Val Thr Glu Glu Thr Pro Glu Gly Glu 
    290                 295                 300                 


Glu His His Pro Val Ala Asp Thr Glu Asn Lys Glu Asn Glu Val Glu 
305                 310                 315                 320 


Glu Val Lys Glu Glu Gly Pro Lys Glu Met Thr Leu Asp Glu Trp Lys 
                325                 330                 335     


Ala Ile Gln Asn Lys Asp Arg Ala Lys Val Glu Phe Asn Ile Arg Lys 
            340                 345                 350         


Pro Asn Glu Gly Ala Asp Gly Gln Trp Lys Lys Gly Phe Val Leu His 
        355                 360                 365             


Lys Ser Lys Ser Glu Glu Ala His Ala Glu Asp Ser Val Met Asp His 
    370                 375                 380                 


His Phe Arg Lys Pro Ala Asn Asp Ile Thr Ser Gln Leu Glu Ile Asn 
385                 390                 395                 400 


Phe Gly Asp Leu Gly Arg Pro Gly Arg Gly Gly Arg Gly Gly Arg Gly 
                405                 410                 415     


Gly Arg Gly Arg Gly Gly Arg Pro Asn Arg Gly Ser Arg Thr Asp Lys 
            420                 425                 430         


Ser Ser Ala Ser Ala Pro Asp Val Asp Asp Pro Glu Ala Phe Pro Ala 
        435                 440                 445             


Leu Ala 
    450 

<210>  602
<211>  7075
<212>  DNA
<213>  Homo sapiens

<400>  602
gttagccctg agcccgaggg ggcgtgagtg aaaccaaaga gcactttcgc gagtcagtta     60

cgccgtcacg gttttttggt ttcaaggtag ctgaagacct agagagttta agggtggcca    120

gagcaggtgg caggactccg cccaccacca cgcttccctt ccttcagccc gcacgcttca    180

ctcccctcat ggggtctcgc ctctcaggcg cgcgcgaaga gttgtcgcgc ggtgcgtcct    240

gggaattgta gtcccgacgc ggagagtcgc ctcaggagaa atgactctgg cctacatacc    300

ccacagtgcc ttgcggcgca ggccgctccc ggatgtgtgc ctggcgccgg aagagaagac    360

ggcccccctc tctcggcccg gccatcttgt gggaagagct gaagcaggcg ctcttggctc    420

ggcgcggccc gctgcaatcc gtggaggaac gcgccgccga gccaccatca tgcctgggca    480

cttacaggaa ggcttcggct gcgtggtcac caaccgattc gaccagttat ttgacgacga    540

atcggacccc ttcgaggtgc tgaaggcagc agagaacaag aaaaaagaag ccggcggggg    600

cggcgttggg ggccctgggg ccaagagcgc agctcaggcc gcggcccaga ccaactccaa    660

cgcggcaggc aaacagctgc gcaaggagtc ccagaaagac cgcaagaacc cgctgccccc    720

cagcgttggc gtggttgaca agaaagagga gacgcagccg cccgtggcgc ttaagaaaga    780

aggaataaga cgagttggaa gaagacctga tcaacaactt cagggtgaag ggaaaataat    840

tgatagaaga ccagaaaggc gaccacctcg tgaacgaaga ttcgaaaagc cacttgaaga    900

aaagggtgaa ggaggcgaat tttcagttga tagaccgatt attgaccgac ctattcgagg    960

tcgtggtggt cttggaagag gtcgaggggg ccgtggacgt ggaatgggcc gaggagatgg   1020

atttgattct cgtggcaaac gtgaatttga taggcatagt ggaagtgata gatctggcct   1080

gaagcacgag gacaaacgtg gaggtagcgg atctcacaac tggggaactg tcaaagacga   1140

attaacagag tcccccaaat acattcagaa acaaatatct tataattaca gtgacttgga   1200

tcaatcaaat gtgactgagg aaacacctga aggtgaagaa catcatccag tggcagacac   1260

tgaaaataag gagaatgaag ttgaagaggt aaaagaggag ggtccaaaag agatgacttt   1320

ggatgagtgg aaggctattc aaaataagga ccgggcaaaa gtagaattta atatccgaaa   1380

accaaatgaa ggtgctgatg ggcagtggaa gaagggattt gttcttcata aatcaaagag   1440

tgaagaggct catgctgaag attcggttat ggaccatcat ttccggaagc cagcaaatga   1500

tataacgtct cagctggaga tcaattttgg agaccttggc cgcccaggac gtggcggcag   1560

gggaggacga ggtggacgtg ggcgtggtgg gcgcccaaac cgtggcagca ggaccgacaa   1620

gtcaagtgct tctgctcctg atgtggatga cccagaggca ttcccagctc tggcttaact   1680

ggatgccata agacaaccct ggttcctttg tgaacccttc tgttcaaagc ttttgcatgc   1740

ttaaggattc caaacgacta agaaattaaa aaaaaaaaga ctgtcattca taccattcac   1800

acctaaagac tgaattttat ctgttttaaa aatgaacttc tcccgctaca cagaagtaac   1860

aaatatggta gtcagttttg tatttagaaa tgtattggta gcagggatgt tttcataatt   1920

ttcagagatt atgcattctt catgaatact tttgtattgc tgcttgcaaa tatgcatttc   1980

caaacttgaa atataggtgt gaacagtgtg taccagttta aagctttcac ttcatttgtg   2040

ttttttaatt aaggatttag aagttccccc aattacaaac tggttttaaa tattggacat   2100

actggtttta atacctgctt tgcatattca cacatggtca actgggacat gttaaacttt   2160

gatttgtcaa attttatgct gtgtggaata ctaactatat gtattttaac ttagttttaa   2220

tattttcatt tttggggaaa aatctttttt cacttctcat gatagctgtt atatatatat   2280

gctaaatctt tatatacaga aatatcagta cttgaacaaa ttcaaagcac atttggttta   2340

ttaacccttg ctccttgcat ggctcattag gttcaaatta taactgattt acattttcag   2400

ctatatttac tttttaaatg cttgagtttc ccattttaaa atctaaacta gacatcttaa   2460

ttggtgaaag ttgtttaaac tacttattgt tggtaggcac atcgtgtcaa gtgaagtagt   2520

tttataggta tgggtttttt ctcccccttc accagggtgg gtggaataag ttgatttggc   2580

caatgtgtaa tatttaaact gttctgtaaa ataagtgtct ggccatttgg tatgatttct   2640

gtgtgtgaaa ggtcccaaaa tcaaaatggt acatccataa tcagccacca tttaaccctt   2700

ccttgttcta aaacaaaaac caaagggcgc tggttggtag ggtgaggtgg gggagtattt   2760

taatttttgg aatttgggaa gcagacagct ttactttgta aggttggaac agcagcacta   2820

tacatgaaat ataaaccaaa aacctttact gtttctaaat ttcctagatt gctattattt   2880

ggttgtaagt tgagtattcc acagaaagtg gtaattatct cttctctctt cctccattag   2940

aaaattaggt aaataatgga ttcctataat gggagcatca ccacttatta aaacacacat   3000

agaatgatga attaaaaaag ttttctagga ttgtctttta ttctgccaca tttattgata   3060

aacagtgaag gaatttttaa aaaattttta agaattgttt gtcacgtcat ttttagaaat   3120

gttctacctg tatatggtaa tgtccagttt taaaaatatt ggacatcttc aatcttaaac   3180

atttctattt agctgattgg ttctcacata tacttctaaa agaaactttt atgttataag   3240

agttactttt tggataagat ttattaatct cagttaccta ctattctgac attttaggaa   3300

ggaggtaatt gtttttaatg atggataaac ttgtgctggt gttttggatc ttatgatgct   3360

gagcatgttc tgcactggtg ctaatgtcta atataatttt atatttacac acatacgtgc   3420

tacccagaga ttaatttagt ccatatgaac tattgaccca ttgttcattg agacagcaac   3480

atacgcactc ctaaatcagt gtgtttagac ttttcaagta tctaactcat ttccaaacat   3540

gtaccatgtt ttataaacct cttgatttcc agcaacatac tatagaaaac acctgctact   3600

caaaacacaa cttctcagtg tcatccattg ctgtcgtgag agacaacata gcaatatctg   3660

gtatgttgca agctttcaag atagcctgaa cttaaaaagt tggtgcatta gttgtatctg   3720

atggatataa atttgcctcc tagttcactt tgtgtcaaga gctaaaactg tgaacctaac   3780

tttctcttat tggtgggtaa taactgaaaa taaagattta ttttcatgct cacttcttaa   3840

aagtcataaa aacaatcaaa taggatcatg tttattgtca tgtgtttcct ggtttctgac   3900

ctgtgtgcac acccctgtgt gtttataatt tttaaattga attttatatg gggtttttat   3960

ttgctaaaaa ccaggctgtt gaatcacatt tgggaagggt acttatctta atgactaatg   4020

acttaattgg gaaagttgaa ttcttgtaaa atacaaaatc caaggacttc ttggatttaa   4080

tctgattgtc acttcttagc agatcacttt tttgataatg aaagttaagc atactgaatg   4140

ctacttttga ttgacaaact ggctataata gtctagggga aaaatcccta aacagataaa   4200

gattcctaaa gtaatggtgg cagctgatgt ttcagtgaac ttttatcttg atgcgtttaa   4260

atggaagtaa tgccagacct gagattttta aggcattttt acagcttgta ttgaaatgat   4320

tggagacatg gtttctttat tagctatttt gagacctgtg gagttaagca agacttttaa   4380

aaattggcac catatacatc tagttagttc ctttactctt atttttttaa ataaaagtag   4440

tacacatcat ttccagggtt gtaaatatat ttggggcttg tttttggtat ggatttaaaa   4500

ggaggatatt aagtattcat tctaattttg ttatttttct agttgccaga gatggttgca   4560

ctgaaataga acagggagtt gcatacaaag cctaaatgtg tattggattt cgaaaatact   4620

aggttggtgc aattggtttt gtaccaacct aacatgtctt taggaaagta ccatcatgtg   4680

gaaggaaaca acaggtgtta aaaggttcaa aggaatgaga aataggaagt tactagaacc   4740

taactgatgt tgaccttaga ggtaagatta ttcaggtata ttagtggacc tccagtccaa   4800

tggtatagca aattccaggg atctcaggtg catgcaattt tactttctaa agtaaacact   4860

tagaaaatag attataaccc agacgttttg gattatactg agacaaatat gtaaataagt   4920

tttagcaagt ctgaacatgt accagcgaga tcttcaggtt aactaagaaa agcccagaaa   4980

cttcattatt tactgtgctt tgtatggcat aactggtaac aaggcagtaa aatgatacat   5040

atttgaactg gaccatagta attaaatgat ttatcaatat catttgcaag ataattgtca   5100

ggttgagtta atagtaagtg gcagcttccc agaaatttgg gttatttggc ctaagctgtg   5160

ccctgggatt acctcttcat cttccttgac ttttaagttc aaatttggag gttatgtgaa   5220

gtgattgaaa taaatctttc aggctgagga agtcggtaat ttcaagaata tagtgaaaac   5280

aaggttgtaa tctaaacatg agaagcttaa gtttaggaaa tggttagaat ataaattgct   5340

aaagccatca tgattttggc cacagatgaa aatatgaaca ctggaaatga gcgccattta   5400

aatgagatgc tgtatgtaag ccaggggtca gcaaagttca gcctgtgacc tggtgtgtgt   5460

gggggtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtcc gtgtccctga gttaagaatg   5520

gtttttaggc ttgtatagga ttaaaaaaaa aaaaaaccca cagaaaaatg taggcagccc   5580

agcataagat accgcctttc acagaaatgt ttgctgaccc cggaactgtc actctcgggt   5640

tacaagagtt tgtttctttg aaacagtctg gctctgtcac ccaggctgga gtgcagtggc   5700

atgatctcag gtcactgcag cctccacctc ccgggttcaa gcaattctgc ctcagcctcc   5760

tgagtagctg ggattacagg tgtgcaccac cacagacagc taattttaca ggtgtacacc   5820

accacaccca agaatcactt gaacccggga ggtgggggtt gcagtgagcc aagatcatag   5880

cactgtactc cagtctgggt gacacactgt ctgaaaaata aaagtttagt tctaggtaca   5940

aattaagtgg tctacccaac aggaagctgt gaaattagaa gtaattttaa agcatacttt   6000

acacctctat ataatcaaag taagggcaag ataaaacttg ttagtaaaac atgttttatt   6060

attttttaga taggtagcct gcaacataaa atatattttg aaagctgtta aggggtgtat   6120

aatctgttaa aaaataccat gattagtatt tcacatttag tgactcagat ccctttgtgt   6180

aagtcctttg cgttgtgcaa agaggttttt ctatgagatg agaattatga acacttcata   6240

taggtaaatt ccataggttg agctggggca gaaattaatg gctcctggag attgcatctt   6300

tttttttttt tttttgagct tagaattccc atttggacag aatttagctt ttgtgctgtt   6360

gattacttct gtactaaact ggtagccaat tgttcacttc taaatggaag ggaaaaagtt   6420

acccacacaa gttagaaaat gatttaccga attatttttt tgagttagta tgtatatact   6480

gttttaaatc agtaatgttt gttccttttg ctgcccattt gggagtatgt ggcaattcct   6540

agtgctcttg tatgacatta ctcttcttga gacttgtata tgcaagaaag tatatataaa   6600

agatgcctgg tggtaacttt gtatctgagt tctgattcat tatggacttt tagaaatcta   6660

tttagataat tggttcatac taggtgctca attactctga ccttgtgtgg cttaatcctt   6720

aaatagttgc tttaggtgtt actgggtgga agcatggaaa gtgaagggct aatattaagg   6780

atttttatgt attactgagt agggaaagtg ggaagtagct tatctttgga cagttgtatt   6840

actttgcact aatcaccttg tttgcagttg tagctgattc agttctagat tttaggacca   6900

aaaagatctc taatttaaag aaacagtttt tatataccta gaatgaagat tctgtttaaa   6960

gcggttttgg ttaacttggt tcttgacatt tgcctaaaat tttgttggat tgggactaaa   7020

atgttctatt agccaatgaa taacgtccaa gtaaattttt gttttatttt gggaa        7075


<210>  603
<211>  465
<212>  PRT
<213>  Homo sapiens

<400>  603


Met Thr Leu Ala Tyr Ile Pro His Ser Ala Leu Arg Arg Arg Pro Leu 
1               5                   10                  15      


Pro Asp Val Cys Leu Ala Pro Glu Glu Lys Thr Ala Pro Leu Ser Arg 
            20                  25                  30          


Pro Gly His Leu Val Gly Arg Ala Glu Ala Gly Ala Leu Gly Ser Ala 
        35                  40                  45              


Arg Pro Ala Ala Ile Arg Gly Gly Thr Arg Arg Arg Ala Thr Ile Met 
    50                  55                  60                  


Pro Gly His Leu Gln Glu Gly Phe Gly Cys Val Val Thr Asn Arg Phe 
65                  70                  75                  80  


Asp Gln Leu Phe Asp Asp Glu Ser Asp Pro Phe Glu Val Leu Lys Ala 
                85                  90                  95      


Ala Glu Asn Lys Lys Lys Glu Ala Gly Gly Gly Gly Val Gly Gly Pro 
            100                 105                 110         


Gly Ala Lys Ser Ala Ala Gln Ala Ala Ala Gln Thr Asn Ser Asn Ala 
        115                 120                 125             


Ala Gly Lys Gln Leu Arg Lys Glu Ser Gln Lys Asp Arg Lys Asn Pro 
    130                 135                 140                 


Leu Pro Pro Ser Val Gly Val Val Asp Lys Lys Glu Glu Thr Gln Pro 
145                 150                 155                 160 


Pro Val Ala Leu Lys Lys Glu Gly Ile Arg Arg Val Gly Arg Arg Pro 
                165                 170                 175     


Asp Gln Gln Leu Gln Gly Glu Gly Lys Ile Ile Asp Arg Arg Pro Glu 
            180                 185                 190         


Arg Arg Pro Pro Arg Glu Arg Arg Phe Glu Lys Pro Leu Glu Glu Lys 
        195                 200                 205             


Gly Glu Gly Gly Glu Phe Ser Val Asp Arg Pro Ile Ile Asp Arg Pro 
    210                 215                 220                 


Ile Arg Gly Arg Gly Gly Leu Gly Arg Gly Arg Gly Gly Arg Gly Arg 
225                 230                 235                 240 


Gly Met Gly Arg Gly Asp Gly Phe Asp Ser Arg Gly Lys Arg Glu Phe 
                245                 250                 255     


Asp Arg His Ser Gly Ser Asp Arg Ser Gly Leu Lys His Glu Asp Lys 
            260                 265                 270         


Arg Gly Gly Ser Gly Ser His Asn Trp Gly Thr Val Lys Asp Glu Leu 
        275                 280                 285             


Thr Glu Ser Pro Lys Tyr Ile Gln Lys Gln Ile Ser Tyr Asn Tyr Ser 
    290                 295                 300                 


Asp Leu Asp Gln Ser Asn Val Thr Glu Glu Thr Pro Glu Gly Glu Glu 
305                 310                 315                 320 


His His Pro Val Ala Asp Thr Glu Asn Lys Glu Asn Glu Val Glu Glu 
                325                 330                 335     


Val Lys Glu Glu Gly Pro Lys Glu Met Thr Leu Asp Glu Trp Lys Ala 
            340                 345                 350         


Ile Gln Asn Lys Asp Arg Ala Lys Val Glu Phe Asn Ile Arg Lys Pro 
        355                 360                 365             


Asn Glu Gly Ala Asp Gly Gln Trp Lys Lys Gly Phe Val Leu His Lys 
    370                 375                 380                 


Ser Lys Ser Glu Glu Ala His Ala Glu Asp Ser Val Met Asp His His 
385                 390                 395                 400 


Phe Arg Lys Pro Ala Asn Asp Ile Thr Ser Gln Leu Glu Ile Asn Phe 
                405                 410                 415     


Gly Asp Leu Gly Arg Pro Gly Arg Gly Gly Arg Gly Gly Arg Gly Gly 
            420                 425                 430         


Arg Gly Arg Gly Gly Arg Pro Asn Arg Gly Ser Arg Thr Asp Lys Ser 
        435                 440                 445             


Ser Ala Ser Ala Pro Asp Val Asp Asp Pro Glu Ala Phe Pro Ala Leu 
    450                 455                 460                 


Ala 
465 

<210>  604
<211>  6226
<212>  DNA
<213>  Homo sapiens

<400>  604
tgtgtagtgt ttcacttgaa tttgtagctc tccaatttgt gtagaaaaac gtagtggttg     60

tgtattaaca gaaaatgctt ctgagaagtt tatatctagt aaggtcttta ccctagttgt    120

agttggaaga gtgtagaaca gagtttttct ttctgagtgt tctttttaac ttcagtgtta    180

gtgctagtag taaccttata tgtcatctct ccagaggtct tcatcaagga ttcacatggc    240

agtcctgatc tgaagggcat atttaaaatg tacttgtcca gatttcactg ctaaagatta    300

tgattcagta ggtctaggat gggcttcagc cgtttgggtt gattgtgata gcatacatgt    360

ctttagttga ggactgctgg tattacctgc aattttgaga tagagaaaag tgcaggaaaa    420

tcttcctcca ggatcactaa agctgagccc tagcttgtta cctgtggagg cattgagaca    480

tttgttcaca gaaagtacag tttggatttt tggttttttt tagaagaaag ctcattattt    540

agaaattttg caatgttact tttctactaa taacacaatc atcttcactt atatttttag    600

gctcatgctg aagattcggt tatggaccat catttccgga agccagcaaa tgatataacg    660

tctcagctgg agatcaattt tggagacctt ggccgcccag gacgtggcgg caggggagga    720

cgaggtggac gtgggcgtgg tgggcgccca aaccgtggca gcaggaccga caagtcaagt    780

gcttctgctc ctgatgtgga tgacccagag gcattcccag ctctggctta actggatgcc    840

ataagacaac cctggttcct ttgtgaaccc ttctgttcaa agcttttgca tgcttaagga    900

ttccaaacga ctaagaaatt aaaaaaaaaa agactgtcat tcataccatt cacacctaaa    960

gactgaattt tatctgtttt aaaaatgaac ttctcccgct acacagaagt aacaaatatg   1020

gtagtcagtt ttgtatttag aaatgtattg gtagcaggga tgttttcata attttcagag   1080

attatgcatt cttcatgaat acttttgtat tgctgcttgc aaatatgcat ttccaaactt   1140

gaaatatagg tgtgaacagt gtgtaccagt ttaaagcttt cacttcattt gtgtttttta   1200

attaaggatt tagaagttcc cccaattaca aactggtttt aaatattgga catactggtt   1260

ttaatacctg ctttgcatat tcacacatgg tcaactggga catgttaaac tttgatttgt   1320

caaattttat gctgtgtgga atactaacta tatgtatttt aacttagttt taatattttc   1380

atttttgggg aaaaatcttt tttcacttct catgatagct gttatatata tatgctaaat   1440

ctttatatac agaaatatca gtacttgaac aaattcaaag cacatttggt ttattaaccc   1500

ttgctccttg catggctcat taggttcaaa ttataactga tttacatttt cagctatatt   1560

tactttttaa atgcttgagt ttcccatttt aaaatctaaa ctagacatct taattggtga   1620

aagttgttta aactacttat tgttggtagg cacatcgtgt caagtgaagt agttttatag   1680

gtatgggttt tttctccccc ttcaccaggg tgggtggaat aagttgattt ggccaatgtg   1740

taatatttaa actgttctgt aaaataagtg tctggccatt tggtatgatt tctgtgtgtg   1800

aaaggtccca aaatcaaaat ggtacatcca taatcagcca ccatttaacc cttccttgtt   1860

ctaaaacaaa aaccaaaggg cgctggttgg tagggtgagg tgggggagta ttttaatttt   1920

tggaatttgg gaagcagaca gctttacttt gtaaggttgg aacagcagca ctatacatga   1980

aatataaacc aaaaaccttt actgtttcta aatttcctag attgctatta tttggttgta   2040

agttgagtat tccacagaaa gtggtaatta tctcttctct cttcctccat tagaaaatta   2100

ggtaaataat ggattcctat aatgggagca tcaccactta ttaaaacaca catagaatga   2160

tgaattaaaa aagttttcta ggattgtctt ttattctgcc acatttattg ataaacagtg   2220

aaggaatttt taaaaaattt ttaagaattg tttgtcacgt catttttaga aatgttctac   2280

ctgtatatgg taatgtccag ttttaaaaat attggacatc ttcaatctta aacatttcta   2340

tttagctgat tggttctcac atatacttct aaaagaaact tttatgttat aagagttact   2400

ttttggataa gatttattaa tctcagttac ctactattct gacattttag gaaggaggta   2460

attgttttta atgatggata aacttgtgct ggtgttttgg atcttatgat gctgagcatg   2520

ttctgcactg gtgctaatgt ctaatataat tttatattta cacacatacg tgctacccag   2580

agattaattt agtccatatg aactattgac ccattgttca ttgagacagc aacatacgca   2640

ctcctaaatc agtgtgttta gacttttcaa gtatctaact catttccaaa catgtaccat   2700

gttttataaa cctcttgatt tccagcaaca tactatagaa aacacctgct actcaaaaca   2760

caacttctca gtgtcatcca ttgctgtcgt gagagacaac atagcaatat ctggtatgtt   2820

gcaagctttc aagatagcct gaacttaaaa agttggtgca ttagttgtat ctgatggata   2880

taaatttgcc tcctagttca ctttgtgtca agagctaaaa ctgtgaacct aactttctct   2940

tattggtggg taataactga aaataaagat ttattttcat gctcacttct taaaagtcat   3000

aaaaacaatc aaataggatc atgtttattg tcatgtgttt cctggtttct gacctgtgtg   3060

cacacccctg tgtgtttata atttttaaat tgaattttat atggggtttt tatttgctaa   3120

aaaccaggct gttgaatcac atttgggaag ggtacttatc ttaatgacta atgacttaat   3180

tgggaaagtt gaattcttgt aaaatacaaa atccaaggac ttcttggatt taatctgatt   3240

gtcacttctt agcagatcac ttttttgata atgaaagtta agcatactga atgctacttt   3300

tgattgacaa actggctata atagtctagg ggaaaaatcc ctaaacagat aaagattcct   3360

aaagtaatgg tggcagctga tgtttcagtg aacttttatc ttgatgcgtt taaatggaag   3420

taatgccaga cctgagattt ttaaggcatt tttacagctt gtattgaaat gattggagac   3480

atggtttctt tattagctat tttgagacct gtggagttaa gcaagacttt taaaaattgg   3540

caccatatac atctagttag ttcctttact cttatttttt taaataaaag tagtacacat   3600

catttccagg gttgtaaata tatttggggc ttgtttttgg tatggattta aaaggaggat   3660

attaagtatt cattctaatt ttgttatttt tctagttgcc agagatggtt gcactgaaat   3720

agaacaggga gttgcataca aagcctaaat gtgtattgga tttcgaaaat actaggttgg   3780

tgcaattggt tttgtaccaa cctaacatgt ctttaggaaa gtaccatcat gtggaaggaa   3840

acaacaggtg ttaaaaggtt caaaggaatg agaaatagga agttactaga acctaactga   3900

tgttgacctt agaggtaaga ttattcaggt atattagtgg acctccagtc caatggtata   3960

gcaaattcca gggatctcag gtgcatgcaa ttttactttc taaagtaaac acttagaaaa   4020

tagattataa cccagacgtt ttggattata ctgagacaaa tatgtaaata agttttagca   4080

agtctgaaca tgtaccagcg agatcttcag gttaactaag aaaagcccag aaacttcatt   4140

atttactgtg ctttgtatgg cataactggt aacaaggcag taaaatgata catatttgaa   4200

ctggaccata gtaattaaat gatttatcaa tatcatttgc aagataattg tcaggttgag   4260

ttaatagtaa gtggcagctt cccagaaatt tgggttattt ggcctaagct gtgccctggg   4320

attacctctt catcttcctt gacttttaag ttcaaatttg gaggttatgt gaagtgattg   4380

aaataaatct ttcaggctga ggaagtcggt aatttcaaga atatagtgaa aacaaggttg   4440

taatctaaac atgagaagct taagtttagg aaatggttag aatataaatt gctaaagcca   4500

tcatgatttt ggccacagat gaaaatatga acactggaaa tgagcgccat ttaaatgaga   4560

tgctgtatgt aagccagggg tcagcaaagt tcagcctgtg acctggtgtg tgtgggggtg   4620

tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tccgtgtccc tgagttaaga atggttttta   4680

ggcttgtata ggattaaaaa aaaaaaaaac ccacagaaaa atgtaggcag cccagcataa   4740

gataccgcct ttcacagaaa tgtttgctga ccccggaact gtcactctcg ggttacaaga   4800

gtttgtttct ttgaaacagt ctggctctgt cacccaggct ggagtgcagt ggcatgatct   4860

caggtcactg cagcctccac ctcccgggtt caagcaattc tgcctcagcc tcctgagtag   4920

ctgggattac aggtgtgcac caccacagac agctaatttt acaggtgtac accaccacac   4980

ccaagaatca cttgaacccg ggaggtgggg gttgcagtga gccaagatca tagcactgta   5040

ctccagtctg ggtgacacac tgtctgaaaa ataaaagttt agttctaggt acaaattaag   5100

tggtctaccc aacaggaagc tgtgaaatta gaagtaattt taaagcatac tttacacctc   5160

tatataatca aagtaagggc aagataaaac ttgttagtaa aacatgtttt attatttttt   5220

agataggtag cctgcaacat aaaatatatt ttgaaagctg ttaaggggtg tataatctgt   5280

taaaaaatac catgattagt atttcacatt tagtgactca gatccctttg tgtaagtcct   5340

ttgcgttgtg caaagaggtt tttctatgag atgagaatta tgaacacttc atataggtaa   5400

attccatagg ttgagctggg gcagaaatta atggctcctg gagattgcat cttttttttt   5460

ttttttttga gcttagaatt cccatttgga cagaatttag cttttgtgct gttgattact   5520

tctgtactaa actggtagcc aattgttcac ttctaaatgg aagggaaaaa gttacccaca   5580

caagttagaa aatgatttac cgaattattt ttttgagtta gtatgtatat actgttttaa   5640

atcagtaatg tttgttcctt ttgctgccca tttgggagta tgtggcaatt cctagtgctc   5700

ttgtatgaca ttactcttct tgagacttgt atatgcaaga aagtatatat aaaagatgcc   5760

tggtggtaac tttgtatctg agttctgatt cattatggac ttttagaaat ctatttagat   5820

aattggttca tactaggtgc tcaattactc tgaccttgtg tggcttaatc cttaaatagt   5880

tgctttaggt gttactgggt ggaagcatgg aaagtgaagg gctaatatta aggattttta   5940

tgtattactg agtagggaaa gtgggaagta gcttatcttt ggacagttgt attactttgc   6000

actaatcacc ttgtttgcag ttgtagctga ttcagttcta gattttagga ccaaaaagat   6060

ctctaattta aagaaacagt ttttatatac ctagaatgaa gattctgttt aaagcggttt   6120

tggttaactt ggttcttgac atttgcctaa aattttgttg gattgggact aaaatgttct   6180

attagccaat gaataacgtc caagtaaatt tttgttttat tttggg                  6226


<210>  605
<211>  69
<212>  PRT
<213>  Homo sapiens

<400>  605


Met Asp His His Phe Arg Lys Pro Ala Asn Asp Ile Thr Ser Gln Leu 
1               5                   10                  15      


Glu Ile Asn Phe Gly Asp Leu Gly Arg Pro Gly Arg Gly Gly Arg Gly 
            20                  25                  30          


Gly Arg Gly Gly Arg Gly Arg Gly Gly Arg Pro Asn Arg Gly Ser Arg 
        35                  40                  45              


Thr Asp Lys Ser Ser Ala Ser Ala Pro Asp Val Asp Asp Pro Glu Ala 
    50                  55                  60                  


Phe Pro Ala Leu Ala 
65                  

<210>  606
<211>  5775
<212>  DNA
<213>  Homo sapiens

<400>  606
tgtgtagtgt ttcacttgaa tttgtagctc tccaatttgt gtagaaaaac gtagtggttg     60

tgtattaaca gaaaatgctt ctgagaagtt tatatctagt aaggtcttta ccctagttgt    120

agttggaaga gtgtagaaca gagtttttct ttctgagtgt tctttttaac ttcagtgtta    180

gtgctagtag taaccttata tgtcatctct ccagaggtct tcatcaagga ttcacatggc    240

agtcctgatc tgaagggcat atttaaaatg tacttgtcca gatttcactg ctaaagatta    300

tgattcagta ggtctaggat gggcttcagc cgtttgggtt gattgtgata gcatacatgt    360

ctttagttga ggactgctgg tattacctgc aattttgaga tagagaaaag tgcaggaaaa    420

tcttcctcca ggatcactaa agctgagccc tagcttgtta cctgtggagg cattgagaca    480

tttgttcaca gaaagtacag tttggatttt tggttttttt tagaagaaag ctcattattt    540

agaaattttg caatgttact tttctactaa taacacaatc atcttcactt atatttttag    600

gctcatgctg aagattcggt tatggaccat catttccgga agccagcaaa tgatataacg    660

tctcagctgg agatcaattt tggagacctt ggccgcccag gacgtggcgg caggggagga    720

cgaggtggac gtgggcgtgg tgggcgccca aaccgtggca gcaggaccga caagtcaagt    780

gcttctgctc ctgatgtgga tgacccagag gcattcccag ctctggctta actggatgcc    840

ataagacaac cctggttcct ttgtgaaccc ttctgttcaa agcttttgca tgcttaagga    900

ttccaaacga ctaagaaatt aaaaaaaaaa agactgtcat tcataccatt cacacctaaa    960

gactgaattt tatctgtttt aaaaatgaac ttctcccgct acacagaagt aacaaatatg   1020

gtagtcagtt ttgtatttag aaatgtattg gtagcaggga tgttttcata attttcagag   1080

attatgcatt cttcatgaat acttttgtat tgctgcttgc aaatatgcat ttccaaactt   1140

gaaatatagg tgtgaacagt gtgtaccagt ttaaagcttt cacttcattt gtgtttttta   1200

attaaggatt tagaagttcc cccaattaca aactggtttt aaatattgga catactggtt   1260

ttaatacctg ctttgcatat tcacacatgg tcaactggga catgttaaac tttgatttgt   1320

caaattttat gctgtgtgga atactaacta tatgtatttt aacttagttt taatattttc   1380

atttttgggg aaaaatcttt tttcacttct catgatagct gttatatata tatgctaaat   1440

ctttatatac agaaatatca gtacttgaac aaattcaaag cacatttggt ttattaaccc   1500

ttgctccttg catggctcat taggttcaaa ttataactga tttacatttt cagctatatt   1560

tactttttaa atgcttgagt ttcccatttt aaaatctaaa ctagacatct taattggtga   1620

aagttgttta aactacttat tgttggtagg cacatcgtgt caagtgaagt agttttatag   1680

gtatgggttt tttctccccc ttcaccaggg tgggtggaat aagttgattt ggccaatgtg   1740

taatatttaa actgttctgt aaaataagtg tctggccatt tggtatgatt tctgtgtgtg   1800

aaaggtccca aaatcaaaat ggtacatcca taatcagcca ccatttaacc cttccttgtt   1860

ctaaaacaaa aaccaaaggg cgctggttgg tagggtgagg tgggggagta ttttaatttt   1920

tggaatttgg gaagcagaca gctttacttt gtaaggttgg aacagcagca ctatacatga   1980

aatataaacc aaaaaccttt actgtttcta aatttcctag attgctatta tttggttgta   2040

agttgagtat tccacagaaa gtggtaatta tctcttctct cttcctccat tagaaaatta   2100

ggtaaataat ggattcctat aatgggagca tcaccactta ttaaaacaca catagaatga   2160

tgaattaaaa aagttttcta ggattgtctt ttattctgcc acatttattg ataaacagtg   2220

aaggaatttt taaaaaattt ttaagaattg tttgtcacgt catttttaga aatgttctac   2280

ctgtatatgg taatgtccag ttttaaaaat attggacatc ttcaatctta aacatttcta   2340

tttagctgat tggttctcac atatacttct aaaagaaact tttatgttat aagagttact   2400

ttttggataa gatttattaa tctcagttac ctactattct gacattttag gaaggaggta   2460

attgttttta atgatggata aacttgtgct ggtgttttgg atcttatgat gctgagcatg   2520

ttctgcactg gtgctaatgt ctaatataat tttatattta cacacatacg tgctacccag   2580

agattaattt agtccatatg aactattgac ccattgttca ttgagacagc aacatacgca   2640

ctcctaaatc agtgtgttta gacttttcaa gtatctaact catttccaaa catgtaccat   2700

gttttataaa cctcttgatt tccagcaaca tactatagaa aacacctgct actcaaaaca   2760

caacttctca gtgtcatcca ttgctgtcgt gagagacaac atagcaatat ctggtatgtt   2820

gcaagctttc aagatagcct gaacttaaaa agttggtgca ttagttgtat ctgatggata   2880

taaatttgcc tcctagttca ctttgtgtca agagctaaaa ctgtgaacct aactttctct   2940

tattggtggg taataactga aaataaagat ttattttcat gctcacttct taaaagtcat   3000

aaaaacaatc aaataggatc atgtttattg tcatgtgttt cctggtttct gacctgtgtg   3060

cacacccctg tgtgtttata atttttaaat tgaattttat atggggtttt tatttgctaa   3120

aaaccaggct gttgaatcac atttgggaag ggtacttatc ttaatgacta atgacttaat   3180

tgggaaagtt gaattcttgt aaaatacaaa atccaaggac ttcttggatt taatctgatt   3240

gtcacttctt agcagatcac ttttttgata atgaaagtta agcatactga atgctacttt   3300

tgattgacaa actggctata atagtctagg ggaaaaatcc ctaaacagat aaagattcct   3360

aaagtaatgg tggcagctga tgtttcagtg aacttttatc ttgatgcgtt taaatggaag   3420

taatgccaga cctgagattt ttaaggcatt tttacagctt gtattgaaat gattggagac   3480

atggtttctt tattagctat tttgagacct gtggagttaa gcaagacttt taaaaattgg   3540

caccatatac atctagttag ttcctttact cttatttttt taaataaaag tagtacacat   3600

catttccagg gttgtaaata tatttggggc ttgtttttgg tatggattta aaaggaggat   3660

attaagtatt cattctaatt ttgttatttt tctagttgcc agagatggtt gcactgaaat   3720

agaacaggga gttgcataca aagcctaaat gtgtattgga tttcgaaaat actaggttgg   3780

tgcaattggt tttgtaccaa cctaacatgt ctttaggaaa gtaccatcat gtggaaggaa   3840

acaacaggtg ttaaaaggtt caaaggaatg agaaatagga agttactaga acctaactga   3900

tgttgacctt agaggtaaga ttattcaggt atattagtgg acctccagtc caatggtata   3960

gcaaattcca gggatctcag gtgcatgcaa ttttactttc taaagtaaac acttagaaaa   4020

tagattataa cccagacgtt ttggattata ctgagacaaa tatgtaaata agttttagca   4080

agtctgaaca tgtaccagcg agatcttcag gttaactaag aaaagcccag aaacttcatt   4140

atttactgtg ctttgtatgg cataactggt aacaaggcag taaaatgata catatttgaa   4200

ctggaccata gtaattaaat gatttatcaa tatcatttgc aagataattg tcaggttgag   4260

ttaatagtaa gtggcagctt cccagaaatt tgggttattt ggcctaagct gtgccctggg   4320

attacctctt catcttcctt gacttttaag ttcaaatttg gaggttatgt gaagtgattg   4380

aaataaatct ttcaggctga ggaagtcggt aatttcaaga atatagtgaa aacaaggttg   4440

taatctaaac atgagaagct taagtttagg aaatggttag aatataaatt gctaaagcca   4500

tcatgatttt ggccacagat gaaaatatga acactggaaa tgagcgccat ttaaatgaga   4560

tgctgtatgt aagccagggg tcagcaaagt tcagcctgtg acctggtgtg tgtgggggtg   4620

tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tccgtgtccc tgagttaaga atggttttta   4680

ggcttgtata ggattaaaaa aaaaaaaaac ccacagaaaa atgtaggcag cccagcataa   4740

gataccgcct ttcacagaaa tgtttgctga ccccggaact gtcactctcg ggttacaaga   4800

gtttgtttct ttgaaacagt ctggctctgt cacccaggct ggagtgcagt ggcatgatct   4860

caggtcactg cagcctccac ctcccgggtt caagcaattc tgcctcagcc tcctgagtag   4920

ctgggattac aggtgtgcac caccacagac agctaatttt acaggtgtac accaccacac   4980

ccaagaatca cttgaacccg ggaggtgggg gttgcagtga gccaagatca tagcactgta   5040

ctccagtctg ggtgacacac tgtctgaaaa ataaaagttt agttctaggt acaaattaag   5100

tggtctaccc aacaggaagc tgtgaaatta gaagtaattt taaagcatac tttacacctc   5160

tatataatca aagtaagggc aagataaaac ttgttagtaa aacatgtttt attatttttt   5220

agataggtag cctgcaacat aaaatatatt ttgaaagctg ttaaggggtg tataatctgt   5280

taaaaaatac catgattagt atttcacatt tagtgactca gatccctttg tgtaagtcct   5340

ttgcgttgtg caaagaggtt tttctatgag atgagaatta tgaacacttc atataggtaa   5400

attccatagg ttgagctggg gcagaaatta atggctcctg gagattgcat cttttttttt   5460

ttttttttga gcttagaatt cccatttgga cagaatttag cttttgtgct gttgattact   5520

tctgtactaa actggtagcc aattgttcac ttctaaatgg aagggaaaaa gttacccaca   5580

caagttagaa aatgatttac cgaattattt ttttgagtta gtatgtatat actgttttaa   5640

atcagtaatg tttgttcctt ttgctgccca tttgggagta tgtggcaatt cctagtgctc   5700

ttgtatgaca ttactcttct tgagacttgt atatgcaaga aagtatatat aaaagatgcc   5760

tggtggtaac tttgt                                                    5775


<210>  607
<211>  69
<212>  PRT
<213>  Homo sapiens

<400>  607


Met Asp His His Phe Arg Lys Pro Ala Asn Asp Ile Thr Ser Gln Leu 
1               5                   10                  15      


Glu Ile Asn Phe Gly Asp Leu Gly Arg Pro Gly Arg Gly Gly Arg Gly 
            20                  25                  30          


Gly Arg Gly Gly Arg Gly Arg Gly Gly Arg Pro Asn Arg Gly Ser Arg 
        35                  40                  45              


Thr Asp Lys Ser Ser Ala Ser Ala Pro Asp Val Asp Asp Pro Glu Ala 
    50                  55                  60                  


Phe Pro Ala Leu Ala 
65                  

<210>  608
<211>  6622
<212>  DNA
<213>  Homo sapiens

<400>  608
gttagccctg agcccgaggg ggcgtgagtg aaaccaaaga gcactttcgc gagtcagtta     60

cgccgtcacg gttttttggt ttcaaggtag ctgaagacct agagagttta agggtggcca    120

gagcaggtgg caggactccg cccaccacca cgcttccctt ccttcagccc gcacgcttca    180

ctcccctcat ggggtctcgc ctctcaggcg cgcgcgaaga gttgtcgcgc ggtgcgtcct    240

gggaattgta gtcccgacgc ggagagtcgc ctcaggagaa atgactctgg cctacatacc    300

ccacagtgcc ttgcggcgca ggccgctccc ggatgtgtgc ctggcgccgg aagagaagac    360

ggcccccctc tctcggcccg gccatcttgt gggaagagct gaagcaggcg ctcttggctc    420

ggcgcggccc gctgcaatcc gtggaggaac gcgccgccga gccaccatca tgcctgggca    480

cttacaggaa ggcttcggct gcgtggtcac caaccgattc gaccagttat ttgacgacga    540

atcggacccc ttcgaggtgc tgaaggcagc agagaacaag aaaaaagaag ccggcggggg    600

cggcgttggg ggccctgggg ccaagagcgc agctcaggcc gcggcccaga ccaactccaa    660

cgcggcaggc aaacagctgc gcaaggagtc ccagaaagac cgcaagaacc cgctgccccc    720

cagcgttggc gtggttgaca agaaagagga gacgcagccg cccgtggcgc ttaagaaaga    780

aggaataaga cgagttggaa gaagacctga tcaacaactt cagggtgaag ggaaaataat    840

tgatagaaga ccagaaaggc gaccacctcg tgaacgaaga ttcgaaaagc cacttgaaga    900

aaagggtgaa ggaggcgaat tttcagttga tagaccgatt attgaccgac ctattcgagg    960

tcgtggtggt cttggaagag gtcgaggggg ccgtggacgt ggaatgggcc gaggagatgg   1020

atttgattct cgtggcaaac gtgaatttga taggcatagt ggaagtgata gatctggcct   1080

gaagcacgag gacaaacgtg gaggtagcgg atctcacaac tggggaactg tcaaagacga   1140

attaacagag tcccccaaat acattcagaa acaaatatct tataattaca gtgacttgga   1200

tcaatcaaat gtgactgagg aaacacctga aggtgaagaa catcatccag tggcagacac   1260

tgaaaataag gagaatgaag ttgaagaggt aaaagaggag ggtccaaaag agatgacttt   1320

ggatgagtgg aaggctattc aaaataagga ccgggcaaaa gtagaattta atatccgaaa   1380

accaaatgaa ggtgctgatg ggcagtggaa gaagggattt gttcttcata aatcaaagag   1440

tgaagaggct catgctgaag attcggttat ggaccatcat ttccggaagc cagcaaatga   1500

tataacgtct cagctggaga tcaattttgg agaccttggc cgcccaggac gtggcggcag   1560

gggaggacga ggtggacgtg ggcgtggtgg gcgcccaaac cgtggcagca ggaccgacaa   1620

gtcaagtgct tctgctcctg atgtggatga cccagaggca ttcccagctc tggcttaact   1680

ggatgccata agacaaccct ggttcctttg tgaacccttc tgttcaaagc ttttgcatgc   1740

ttaaggattc caaacgacta agaaattaaa aaaaaaaaga ctgtcattca taccattcac   1800

acctaaagac tgaattttat ctgttttaaa aatgaacttc tcccgctaca cagaagtaac   1860

aaatatggta gtcagttttg tatttagaaa tgtattggta gcagggatgt tttcataatt   1920

ttcagagatt atgcattctt catgaatact tttgtattgc tgcttgcaaa tatgcatttc   1980

caaacttgaa atataggtgt gaacagtgtg taccagttta aagctttcac ttcatttgtg   2040

ttttttaatt aaggatttag aagttccccc aattacaaac tggttttaaa tattggacat   2100

actggtttta atacctgctt tgcatattca cacatggtca actgggacat gttaaacttt   2160

gatttgtcaa attttatgct gtgtggaata ctaactatat gtattttaac ttagttttaa   2220

tattttcatt tttggggaaa aatctttttt cacttctcat gatagctgtt atatatatat   2280

gctaaatctt tatatacaga aatatcagta cttgaacaaa ttcaaagcac atttggttta   2340

ttaacccttg ctccttgcat ggctcattag gttcaaatta taactgattt acattttcag   2400

ctatatttac tttttaaatg cttgagtttc ccattttaaa atctaaacta gacatcttaa   2460

ttggtgaaag ttgtttaaac tacttattgt tggtaggcac atcgtgtcaa gtgaagtagt   2520

tttataggta tgggtttttt ctcccccttc accagggtgg gtggaataag ttgatttggc   2580

caatgtgtaa tatttaaact gttctgtaaa ataagtgtct ggccatttgg tatgatttct   2640

gtgtgtgaaa ggtcccaaaa tcaaaatggt acatccataa tcagccacca tttaaccctt   2700

ccttgttcta aaacaaaaac caaagggcgc tggttggtag ggtgaggtgg gggagtattt   2760

taatttttgg aatttgggaa gcagacagct ttactttgta aggttggaac agcagcacta   2820

tacatgaaat ataaaccaaa aacctttact gtttctaaat ttcctagatt gctattattt   2880

ggttgtaagt tgagtattcc acagaaagtg gtaattatct cttctctctt cctccattag   2940

aaaattaggt aaataatgga ttcctataat gggagcatca ccacttatta aaacacacat   3000

agaatgatga attaaaaaag ttttctagga ttgtctttta ttctgccaca tttattgata   3060

aacagtgaag gaatttttaa aaaattttta agaattgttt gtcacgtcat ttttagaaat   3120

gttctacctg tatatggtaa tgtccagttt taaaaatatt ggacatcttc aatcttaaac   3180

atttctattt agctgattgg ttctcacata tacttctaaa agaaactttt atgttataag   3240

agttactttt tggataagat ttattaatct cagttaccta ctattctgac attttaggaa   3300

ggaggtaatt gtttttaatg atggataaac ttgtgctggt gttttggatc ttatgatgct   3360

gagcatgttc tgcactggtg ctaatgtcta atataatttt atatttacac acatacgtgc   3420

tacccagaga ttaatttagt ccatatgaac tattgaccca ttgttcattg agacagcaac   3480

atacgcactc ctaaatcagt gtgtttagac ttttcaagta tctaactcat ttccaaacat   3540

gtaccatgtt ttataaacct cttgatttcc agcaacatac tatagaaaac acctgctact   3600

caaaacacaa cttctcagtg tcatccattg ctgtcgtgag agacaacata gcaatatctg   3660

gtatgttgca agctttcaag atagcctgaa cttaaaaagt tggtgcatta gttgtatctg   3720

atggatataa atttgcctcc tagttcactt tgtgtcaaga gctaaaactg tgaacctaac   3780

tttctcttat tggtgggtaa taactgaaaa taaagattta ttttcatgct cacttcttaa   3840

aagtcataaa aacaatcaaa taggatcatg tttattgtca tgtgtttcct ggtttctgac   3900

ctgtgtgcac acccctgtgt gtttataatt tttaaattga attttatatg gggtttttat   3960

ttgctaaaaa ccaggctgtt gaatcacatt tgggaagggt acttatctta atgactaatg   4020

acttaattgg gaaagttgaa ttcttgtaaa atacaaaatc caaggacttc ttggatttaa   4080

tctgattgtc acttcttagc agatcacttt tttgataatg aaagttaagc atactgaatg   4140

ctacttttga ttgacaaact ggctataata gtctagggga aaaatcccta aacagataaa   4200

gattcctaaa gtaatggtgg cagctgatgt ttcagtgaac ttttatcttg atgcgtttaa   4260

atggaagtaa tgccagacct gagattttta aggcattttt acagcttgta ttgaaatgat   4320

tggagacatg gtttctttat tagctatttt gagacctgtg gagttaagca agacttttaa   4380

aaattggcac catatacatc tagttagttc ctttactctt atttttttaa ataaaagtag   4440

tacacatcat ttccagggtt gtaaatatat ttggggcttg tttttggtat ggatttaaaa   4500

ggaggatatt aagtattcat tctaattttg ttatttttct agttgccaga gatggttgca   4560

ctgaaataga acagggagtt gcatacaaag cctaaatgtg tattggattt cgaaaatact   4620

aggttggtgc aattggtttt gtaccaacct aacatgtctt taggaaagta ccatcatgtg   4680

gaaggaaaca acaggtgtta aaaggttcaa aggaatgaga aataggaagt tactagaacc   4740

taactgatgt tgaccttaga ggtaagatta ttcaggtata ttagtggacc tccagtccaa   4800

tggtatagca aattccaggg atctcaggtg catgcaattt tactttctaa agtaaacact   4860

tagaaaatag attataaccc agacgttttg gattatactg agacaaatat gtaaataagt   4920

tttagcaagt ctgaacatgt accagcgaga tcttcaggtt aactaagaaa agcccagaaa   4980

cttcattatt tactgtgctt tgtatggcat aactggtaac aaggcagtaa aatgatacat   5040

atttgaactg gaccatagta attaaatgat ttatcaatat catttgcaag ataattgtca   5100

ggttgagtta atagtaagtg gcagcttccc agaaatttgg gttatttggc ctaagctgtg   5160

ccctgggatt acctcttcat cttccttgac ttttaagttc aaatttggag gttatgtgaa   5220

gtgattgaaa taaatctttc aggctgagga agtcggtaat ttcaagaata tagtgaaaac   5280

aaggttgtaa tctaaacatg agaagcttaa gtttaggaaa tggttagaat ataaattgct   5340

aaagccatca tgattttggc cacagatgaa aatatgaaca ctggaaatga gcgccattta   5400

aatgagatgc tgtatgtaag ccaggggtca gcaaagttca gcctgtgacc tggtgtgtgt   5460

gggggtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtcc gtgtccctga gttaagaatg   5520

gtttttaggc ttgtatagga ttaaaaaaaa aaaaaaccca cagaaaaatg taggcagccc   5580

agcataagat accgcctttc acagaaatgt ttgctgaccc cggaactgtc actctcgggt   5640

tacaagagtt tgtttctttg aaacagtctg gctctgtcac ccaggctgga gtgcagtggc   5700

atgatctcag gtcactgcag cctccacctc ccgggttcaa gcaattctgc ctcagcctcc   5760

tgagtagctg ggattacagg tgtgcaccac cacagacagc taattttaca ggtgtacacc   5820

accacaccca agaatcactt gaacccggga ggtgggggtt gcagtgagcc aagatcatag   5880

cactgtactc cagtctgggt gacacactgt ctgaaaaata aaagtttagt tctaggtaca   5940

aattaagtgg tctacccaac aggaagctgt gaaattagaa gtaattttaa agcatacttt   6000

acacctctat ataatcaaag taagggcaag ataaaacttg ttagtaaaac atgttttatt   6060

attttttaga taggtagcct gcaacataaa atatattttg aaagctgtta aggggtgtat   6120

aatctgttaa aaaataccat gattagtatt tcacatttag tgactcagat ccctttgtgt   6180

aagtcctttg cgttgtgcaa agaggttttt ctatgagatg agaattatga acacttcata   6240

taggtaaatt ccataggttg agctggggca gaaattaatg gctcctggag attgcatctt   6300

tttttttttt tttttgagct tagaattccc atttggacag aatttagctt ttgtgctgtt   6360

gattacttct gtactaaact ggtagccaat tgttcacttc taaatggaag ggaaaaagtt   6420

acccacacaa gttagaaaat gatttaccga attatttttt tgagttagta tgtatatact   6480

gttttaaatc agtaatgttt gttccttttg ctgcccattt gggagtatgt ggcaattcct   6540

agtgctcttg tatgacatta ctcttcttga gacttgtata tgcaagaaag tatatataaa   6600

agatgcctgg tggtaacttt gt                                            6622


<210>  609
<211>  465
<212>  PRT
<213>  Homo sapiens

<400>  609


Met Thr Leu Ala Tyr Ile Pro His Ser Ala Leu Arg Arg Arg Pro Leu 
1               5                   10                  15      


Pro Asp Val Cys Leu Ala Pro Glu Glu Lys Thr Ala Pro Leu Ser Arg 
            20                  25                  30          


Pro Gly His Leu Val Gly Arg Ala Glu Ala Gly Ala Leu Gly Ser Ala 
        35                  40                  45              


Arg Pro Ala Ala Ile Arg Gly Gly Thr Arg Arg Arg Ala Thr Ile Met 
    50                  55                  60                  


Pro Gly His Leu Gln Glu Gly Phe Gly Cys Val Val Thr Asn Arg Phe 
65                  70                  75                  80  


Asp Gln Leu Phe Asp Asp Glu Ser Asp Pro Phe Glu Val Leu Lys Ala 
                85                  90                  95      


Ala Glu Asn Lys Lys Lys Glu Ala Gly Gly Gly Gly Val Gly Gly Pro 
            100                 105                 110         


Gly Ala Lys Ser Ala Ala Gln Ala Ala Ala Gln Thr Asn Ser Asn Ala 
        115                 120                 125             


Ala Gly Lys Gln Leu Arg Lys Glu Ser Gln Lys Asp Arg Lys Asn Pro 
    130                 135                 140                 


Leu Pro Pro Ser Val Gly Val Val Asp Lys Lys Glu Glu Thr Gln Pro 
145                 150                 155                 160 


Pro Val Ala Leu Lys Lys Glu Gly Ile Arg Arg Val Gly Arg Arg Pro 
                165                 170                 175     


Asp Gln Gln Leu Gln Gly Glu Gly Lys Ile Ile Asp Arg Arg Pro Glu 
            180                 185                 190         


Arg Arg Pro Pro Arg Glu Arg Arg Phe Glu Lys Pro Leu Glu Glu Lys 
        195                 200                 205             


Gly Glu Gly Gly Glu Phe Ser Val Asp Arg Pro Ile Ile Asp Arg Pro 
    210                 215                 220                 


Ile Arg Gly Arg Gly Gly Leu Gly Arg Gly Arg Gly Gly Arg Gly Arg 
225                 230                 235                 240 


Gly Met Gly Arg Gly Asp Gly Phe Asp Ser Arg Gly Lys Arg Glu Phe 
                245                 250                 255     


Asp Arg His Ser Gly Ser Asp Arg Ser Gly Leu Lys His Glu Asp Lys 
            260                 265                 270         


Arg Gly Gly Ser Gly Ser His Asn Trp Gly Thr Val Lys Asp Glu Leu 
        275                 280                 285             


Thr Glu Ser Pro Lys Tyr Ile Gln Lys Gln Ile Ser Tyr Asn Tyr Ser 
    290                 295                 300                 


Asp Leu Asp Gln Ser Asn Val Thr Glu Glu Thr Pro Glu Gly Glu Glu 
305                 310                 315                 320 


His His Pro Val Ala Asp Thr Glu Asn Lys Glu Asn Glu Val Glu Glu 
                325                 330                 335     


Val Lys Glu Glu Gly Pro Lys Glu Met Thr Leu Asp Glu Trp Lys Ala 
            340                 345                 350         


Ile Gln Asn Lys Asp Arg Ala Lys Val Glu Phe Asn Ile Arg Lys Pro 
        355                 360                 365             


Asn Glu Gly Ala Asp Gly Gln Trp Lys Lys Gly Phe Val Leu His Lys 
    370                 375                 380                 


Ser Lys Ser Glu Glu Ala His Ala Glu Asp Ser Val Met Asp His His 
385                 390                 395                 400 


Phe Arg Lys Pro Ala Asn Asp Ile Thr Ser Gln Leu Glu Ile Asn Phe 
                405                 410                 415     


Gly Asp Leu Gly Arg Pro Gly Arg Gly Gly Arg Gly Gly Arg Gly Gly 
            420                 425                 430         


Arg Gly Arg Gly Gly Arg Pro Asn Arg Gly Ser Arg Thr Asp Lys Ser 
        435                 440                 445             


Ser Ala Ser Ala Pro Asp Val Asp Asp Pro Glu Ala Phe Pro Ala Leu 
    450                 455                 460                 


Ala 
465 

<210>  610
<211>  6577
<212>  DNA
<213>  Homo sapiens

<400>  610
gttagccctg agcccgaggg ggcgtgagtg aaaccaaaga gcactttcgc gagtcagtta     60

cgccgtcacg gttttttggt ttcaaggtag ctgaagacct agagagttta agggtggcca    120

gagcaggtgg caggactccg cccaccacca cgcttccctt ccttcagccc gcacgcttca    180

ctcccctcat ggggtctcgc ctctcaggcg cgcgcgaaga gttgtcgcgc ggtgcgtcct    240

gggaattgta gtcccgacgc ggagagtcgc ctcaggagaa atgactctgg cctacatacc    300

ccacagtgcc ttgcggcgca ggccgctccc ggatgtgtgc ctggcgccgg aagagaagac    360

ggcccccctc tctcggcccg gccatcttgt gggaagagct gaagcaggcg ctcttggctc    420

ggcgcggccc gctgcaatcc gtggaggaac gcgccgccga gccaccatca tgcctgggca    480

cttacaggaa ggcttcggct gcgtggtcac caaccgattc gaccagttat ttgacgacga    540

atcggacccc ttcgaggtgc tgaaggcagc agagaacaag aaaaaagaag ccggcggggg    600

cggcgttggg ggccctgggg ccaagagcgc agctcaggcc gcggcccaga ccaactccaa    660

cgcggcaggc aaacagctgc gcaaggagtc ccagaaagac cgcaagaacc cgctgccccc    720

cagcgttggc gtggttgaca agaaagagga gacgcagccg cccgtggcgc ttaagaaaga    780

aggaataaga cgagttggaa gaagacctga tcaacaactt cagggtgaag ggaaaataat    840

tgatagaaga ccagaaaggc gaccacctcg tgaacgaaga ttcgaaaagc cacttgaaga    900

aaagggtgaa ggaggcgaat tttcagttga tagaccgatt attgaccgac ctattcgagg    960

tcgtggtggt cttggaagag gtcgaggggg ccgtggacgt ggaatgggcc gaggagatgg   1020

atttgattct cgtggcaaac gtgaatttga taggcatagt ggaagtgata gatctggcct   1080

gaagcacgag gacaaacgtg gaggtagcgg atctcacaac tggggaactg tcaaagacga   1140

attaactgac ttggatcaat caaatgtgac tgaggaaaca cctgaaggtg aagaacatca   1200

tccagtggca gacactgaaa ataaggagaa tgaagttgaa gaggtaaaag aggagggtcc   1260

aaaagagatg actttggatg agtggaaggc tattcaaaat aaggaccggg caaaagtaga   1320

atttaatatc cgaaaaccaa atgaaggtgc tgatgggcag tggaagaagg gatttgttct   1380

tcataaatca aagagtgaag aggctcatgc tgaagattcg gttatggacc atcatttccg   1440

gaagccagca aatgatataa cgtctcagct ggagatcaat tttggagacc ttggccgccc   1500

aggacgtggc ggcaggggag gacgaggtgg acgtgggcgt ggtgggcgcc caaaccgtgg   1560

cagcaggacc gacaagtcaa gtgcttctgc tcctgatgtg gatgacccag aggcattccc   1620

agctctggct taactggatg ccataagaca accctggttc ctttgtgaac ccttctgttc   1680

aaagcttttg catgcttaag gattccaaac gactaagaaa ttaaaaaaaa aaagactgtc   1740

attcatacca ttcacaccta aagactgaat tttatctgtt ttaaaaatga acttctcccg   1800

ctacacagaa gtaacaaata tggtagtcag ttttgtattt agaaatgtat tggtagcagg   1860

gatgttttca taattttcag agattatgca ttcttcatga atacttttgt attgctgctt   1920

gcaaatatgc atttccaaac ttgaaatata ggtgtgaaca gtgtgtacca gtttaaagct   1980

ttcacttcat ttgtgttttt taattaagga tttagaagtt cccccaatta caaactggtt   2040

ttaaatattg gacatactgg ttttaatacc tgctttgcat attcacacat ggtcaactgg   2100

gacatgttaa actttgattt gtcaaatttt atgctgtgtg gaatactaac tatatgtatt   2160

ttaacttagt tttaatattt tcatttttgg ggaaaaatct tttttcactt ctcatgatag   2220

ctgttatata tatatgctaa atctttatat acagaaatat cagtacttga acaaattcaa   2280

agcacatttg gtttattaac ccttgctcct tgcatggctc attaggttca aattataact   2340

gatttacatt ttcagctata tttacttttt aaatgcttga gtttcccatt ttaaaatcta   2400

aactagacat cttaattggt gaaagttgtt taaactactt attgttggta ggcacatcgt   2460

gtcaagtgaa gtagttttat aggtatgggt tttttctccc ccttcaccag ggtgggtgga   2520

ataagttgat ttggccaatg tgtaatattt aaactgttct gtaaaataag tgtctggcca   2580

tttggtatga tttctgtgtg tgaaaggtcc caaaatcaaa atggtacatc cataatcagc   2640

caccatttaa cccttccttg ttctaaaaca aaaaccaaag ggcgctggtt ggtagggtga   2700

ggtgggggag tattttaatt tttggaattt gggaagcaga cagctttact ttgtaaggtt   2760

ggaacagcag cactatacat gaaatataaa ccaaaaacct ttactgtttc taaatttcct   2820

agattgctat tatttggttg taagttgagt attccacaga aagtggtaat tatctcttct   2880

ctcttcctcc attagaaaat taggtaaata atggattcct ataatgggag catcaccact   2940

tattaaaaca cacatagaat gatgaattaa aaaagttttc taggattgtc ttttattctg   3000

ccacatttat tgataaacag tgaaggaatt tttaaaaaat ttttaagaat tgtttgtcac   3060

gtcattttta gaaatgttct acctgtatat ggtaatgtcc agttttaaaa atattggaca   3120

tcttcaatct taaacatttc tatttagctg attggttctc acatatactt ctaaaagaaa   3180

cttttatgtt ataagagtta ctttttggat aagatttatt aatctcagtt acctactatt   3240

ctgacatttt aggaaggagg taattgtttt taatgatgga taaacttgtg ctggtgtttt   3300

ggatcttatg atgctgagca tgttctgcac tggtgctaat gtctaatata attttatatt   3360

tacacacata cgtgctaccc agagattaat ttagtccata tgaactattg acccattgtt   3420

cattgagaca gcaacatacg cactcctaaa tcagtgtgtt tagacttttc aagtatctaa   3480

ctcatttcca aacatgtacc atgttttata aacctcttga tttccagcaa catactatag   3540

aaaacacctg ctactcaaaa cacaacttct cagtgtcatc cattgctgtc gtgagagaca   3600

acatagcaat atctggtatg ttgcaagctt tcaagatagc ctgaacttaa aaagttggtg   3660

cattagttgt atctgatgga tataaatttg cctcctagtt cactttgtgt caagagctaa   3720

aactgtgaac ctaactttct cttattggtg ggtaataact gaaaataaag atttattttc   3780

atgctcactt cttaaaagtc ataaaaacaa tcaaatagga tcatgtttat tgtcatgtgt   3840

ttcctggttt ctgacctgtg tgcacacccc tgtgtgttta taatttttaa attgaatttt   3900

atatggggtt tttatttgct aaaaaccagg ctgttgaatc acatttggga agggtactta   3960

tcttaatgac taatgactta attgggaaag ttgaattctt gtaaaataca aaatccaagg   4020

acttcttgga tttaatctga ttgtcacttc ttagcagatc acttttttga taatgaaagt   4080

taagcatact gaatgctact tttgattgac aaactggcta taatagtcta ggggaaaaat   4140

ccctaaacag ataaagattc ctaaagtaat ggtggcagct gatgtttcag tgaactttta   4200

tcttgatgcg tttaaatgga agtaatgcca gacctgagat ttttaaggca tttttacagc   4260

ttgtattgaa atgattggag acatggtttc tttattagct attttgagac ctgtggagtt   4320

aagcaagact tttaaaaatt ggcaccatat acatctagtt agttccttta ctcttatttt   4380

tttaaataaa agtagtacac atcatttcca gggttgtaaa tatatttggg gcttgttttt   4440

ggtatggatt taaaaggagg atattaagta ttcattctaa ttttgttatt tttctagttg   4500

ccagagatgg ttgcactgaa atagaacagg gagttgcata caaagcctaa atgtgtattg   4560

gatttcgaaa atactaggtt ggtgcaattg gttttgtacc aacctaacat gtctttagga   4620

aagtaccatc atgtggaagg aaacaacagg tgttaaaagg ttcaaaggaa tgagaaatag   4680

gaagttacta gaacctaact gatgttgacc ttagaggtaa gattattcag gtatattagt   4740

ggacctccag tccaatggta tagcaaattc cagggatctc aggtgcatgc aattttactt   4800

tctaaagtaa acacttagaa aatagattat aacccagacg ttttggatta tactgagaca   4860

aatatgtaaa taagttttag caagtctgaa catgtaccag cgagatcttc aggttaacta   4920

agaaaagccc agaaacttca ttatttactg tgctttgtat ggcataactg gtaacaaggc   4980

agtaaaatga tacatatttg aactggacca tagtaattaa atgatttatc aatatcattt   5040

gcaagataat tgtcaggttg agttaatagt aagtggcagc ttcccagaaa tttgggttat   5100

ttggcctaag ctgtgccctg ggattacctc ttcatcttcc ttgactttta agttcaaatt   5160

tggaggttat gtgaagtgat tgaaataaat ctttcaggct gaggaagtcg gtaatttcaa   5220

gaatatagtg aaaacaaggt tgtaatctaa acatgagaag cttaagttta ggaaatggtt   5280

agaatataaa ttgctaaagc catcatgatt ttggccacag atgaaaatat gaacactgga   5340

aatgagcgcc atttaaatga gatgctgtat gtaagccagg ggtcagcaaa gttcagcctg   5400

tgacctggtg tgtgtggggg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtccgtgtc   5460

cctgagttaa gaatggtttt taggcttgta taggattaaa aaaaaaaaaa acccacagaa   5520

aaatgtaggc agcccagcat aagataccgc ctttcacaga aatgtttgct gaccccggaa   5580

ctgtcactct cgggttacaa gagtttgttt ctttgaaaca gtctggctct gtcacccagg   5640

ctggagtgca gtggcatgat ctcaggtcac tgcagcctcc acctcccggg ttcaagcaat   5700

tctgcctcag cctcctgagt agctgggatt acaggtgtgc accaccacag acagctaatt   5760

ttacaggtgt acaccaccac acccaagaat cacttgaacc cgggaggtgg gggttgcagt   5820

gagccaagat catagcactg tactccagtc tgggtgacac actgtctgaa aaataaaagt   5880

ttagttctag gtacaaatta agtggtctac ccaacaggaa gctgtgaaat tagaagtaat   5940

tttaaagcat actttacacc tctatataat caaagtaagg gcaagataaa acttgttagt   6000

aaaacatgtt ttattatttt ttagataggt agcctgcaac ataaaatata ttttgaaagc   6060

tgttaagggg tgtataatct gttaaaaaat accatgatta gtatttcaca tttagtgact   6120

cagatccctt tgtgtaagtc ctttgcgttg tgcaaagagg tttttctatg agatgagaat   6180

tatgaacact tcatataggt aaattccata ggttgagctg gggcagaaat taatggctcc   6240

tggagattgc atcttttttt tttttttttt gagcttagaa ttcccatttg gacagaattt   6300

agcttttgtg ctgttgatta cttctgtact aaactggtag ccaattgttc acttctaaat   6360

ggaagggaaa aagttaccca cacaagttag aaaatgattt accgaattat ttttttgagt   6420

tagtatgtat atactgtttt aaatcagtaa tgtttgttcc ttttgctgcc catttgggag   6480

tatgtggcaa ttcctagtgc tcttgtatga cattactctt cttgagactt gtatatgcaa   6540

gaaagtatat ataaaagatg cctggtggta actttgt                            6577


<210>  611
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  611


Met Thr Leu Ala Tyr Ile Pro His Ser Ala Leu Arg Arg Arg Pro Leu 
1               5                   10                  15      


Pro Asp Val Cys Leu Ala Pro Glu Glu Lys Thr Ala Pro Leu Ser Arg 
            20                  25                  30          


Pro Gly His Leu Val Gly Arg Ala Glu Ala Gly Ala Leu Gly Ser Ala 
        35                  40                  45              


Arg Pro Ala Ala Ile Arg Gly Gly Thr Arg Arg Arg Ala Thr Ile Met 
    50                  55                  60                  


Pro Gly His Leu Gln Glu Gly Phe Gly Cys Val Val Thr Asn Arg Phe 
65                  70                  75                  80  


Asp Gln Leu Phe Asp Asp Glu Ser Asp Pro Phe Glu Val Leu Lys Ala 
                85                  90                  95      


Ala Glu Asn Lys Lys Lys Glu Ala Gly Gly Gly Gly Val Gly Gly Pro 
            100                 105                 110         


Gly Ala Lys Ser Ala Ala Gln Ala Ala Ala Gln Thr Asn Ser Asn Ala 
        115                 120                 125             


Ala Gly Lys Gln Leu Arg Lys Glu Ser Gln Lys Asp Arg Lys Asn Pro 
    130                 135                 140                 


Leu Pro Pro Ser Val Gly Val Val Asp Lys Lys Glu Glu Thr Gln Pro 
145                 150                 155                 160 


Pro Val Ala Leu Lys Lys Glu Gly Ile Arg Arg Val Gly Arg Arg Pro 
                165                 170                 175     


Asp Gln Gln Leu Gln Gly Glu Gly Lys Ile Ile Asp Arg Arg Pro Glu 
            180                 185                 190         


Arg Arg Pro Pro Arg Glu Arg Arg Phe Glu Lys Pro Leu Glu Glu Lys 
        195                 200                 205             


Gly Glu Gly Gly Glu Phe Ser Val Asp Arg Pro Ile Ile Asp Arg Pro 
    210                 215                 220                 


Ile Arg Gly Arg Gly Gly Leu Gly Arg Gly Arg Gly Gly Arg Gly Arg 
225                 230                 235                 240 


Gly Met Gly Arg Gly Asp Gly Phe Asp Ser Arg Gly Lys Arg Glu Phe 
                245                 250                 255     


Asp Arg His Ser Gly Ser Asp Arg Ser Gly Leu Lys His Glu Asp Lys 
            260                 265                 270         


Arg Gly Gly Ser Gly Ser His Asn Trp Gly Thr Val Lys Asp Glu Leu 
        275                 280                 285             


Thr Asp Leu Asp Gln Ser Asn Val Thr Glu Glu Thr Pro Glu Gly Glu 
    290                 295                 300                 


Glu His His Pro Val Ala Asp Thr Glu Asn Lys Glu Asn Glu Val Glu 
305                 310                 315                 320 


Glu Val Lys Glu Glu Gly Pro Lys Glu Met Thr Leu Asp Glu Trp Lys 
                325                 330                 335     


Ala Ile Gln Asn Lys Asp Arg Ala Lys Val Glu Phe Asn Ile Arg Lys 
            340                 345                 350         


Pro Asn Glu Gly Ala Asp Gly Gln Trp Lys Lys Gly Phe Val Leu His 
        355                 360                 365             


Lys Ser Lys Ser Glu Glu Ala His Ala Glu Asp Ser Val Met Asp His 
    370                 375                 380                 


His Phe Arg Lys Pro Ala Asn Asp Ile Thr Ser Gln Leu Glu Ile Asn 
385                 390                 395                 400 


Phe Gly Asp Leu Gly Arg Pro Gly Arg Gly Gly Arg Gly Gly Arg Gly 
                405                 410                 415     


Gly Arg Gly Arg Gly Gly Arg Pro Asn Arg Gly Ser Arg Thr Asp Lys 
            420                 425                 430         


Ser Ser Ala Ser Ala Pro Asp Val Asp Asp Pro Glu Ala Phe Pro Ala 
        435                 440                 445             


Leu Ala 
    450 

<210>  612
<211>  3020
<212>  DNA
<213>  Homo sapiens

<400>  612
tgtgtagtgt ttcacttgaa tttgtagctc tccaatttgt gtagaaaaac gtagtggttg     60

tgtattaaca gaaaatgctt ctgagaagtt tatatctagt aaggtcttta ccctagttgt    120

agttggaaga gtgtagaaca gagtttttct ttctgagtgt tctttttaac ttcagtgtta    180

gtgctagtag taaccttata tgtcatctct ccagaggtct tcatcaagga ttcacatggc    240

agtcctgatc tgaagggcat atttaaaatg tacttgtcca gatttcactg ctaaagatta    300

tgattcagta ggtctaggat gggcttcagc cgtttgggtt gattgtgata gcatacatgt    360

ctttagttga ggactgctgg tattacctgc aattttgaga tagagaaaag tgcaggaaaa    420

tcttcctcca ggatcactaa agctgagccc tagcttgtta cctgtggagg cattgagaca    480

tttgttcaca gaaagtacag tttggatttt tggttttttt tagaagaaag ctcattattt    540

agaaattttg caatgttact tttctactaa taacacaatc atcttcactt atatttttag    600

gctcatgctg aagattcggt tatggaccat catttccgga agccagcaaa tgatataacg    660

tctcagctgg agatcaattt tggagacctt ggccgcccag gacgtggcgg caggggagga    720

cgaggtggac gtgggcgtgg tgggcgccca aaccgtggca gcaggaccga caagtcaagt    780

gcttctgctc ctgatgtgga tgacccagag gcattcccag ctctggctta actggatgcc    840

ataagacaac cctggttcct ttgtgaaccc ttctgttcaa agcttttgca tgcttaagga    900

ttccaaacga ctaagaaatt aaaaaaaaaa agactgtcat tcataccatt cacacctaaa    960

gactgaattt tatctgtttt aaaaatgaac ttctcccgct acacagaagt aacaaatatg   1020

gtagtcagtt ttgtatttag aaatgtattg gtagcaggga tgttttcata attttcagag   1080

attatgcatt cttcatgaat acttttgtat tgctgcttgc aaatatgcat ttccaaactt   1140

gaaatatagg tgtgaacagt gtgtaccagt ttaaagcttt cacttcattt gtgtttttta   1200

attaaggatt tagaagttcc cccaattaca aactggtttt aaatattgga catactggtt   1260

ttaatacctg ctttgcatat tcacacatgg tcaactggga catgttaaac tttgatttgt   1320

caaattttat gctgtgtgga atactaacta tatgtatttt aacttagttt taatattttc   1380

atttttgggg aaaaatcttt tttcacttct catgatagct gttatatata tatgctaaat   1440

ctttatatac agaaatatca gtacttgaac aaattcaaag cacatttggt ttattaaccc   1500

ttgctccttg catggctcat taggttcaaa ttataactga tttacatttt cagctatatt   1560

tactttttaa atgcttgagt ttcccatttt aaaatctaaa ctagacatct taattggtga   1620

aagttgttta aactacttat tgttggtagg cacatcgtgt caagtgaagt agttttatag   1680

gtatgggttt tttctccccc ttcaccaggg tgggtggaat aagttgattt ggccaatgtg   1740

taatatttaa actgttctgt aaaataagtg tctggccatt tggtatgatt tctgtgtgtg   1800

aaaggtccca aaatcaaaat ggtacatcca taatcagcca ccatttaacc cttccttgtt   1860

ctaaaacaaa aaccaaaggg cgctggttgg tagggtgagg tgggggagta ttttaatttt   1920

tggaatttgg gaagcagaca gctttacttt gtaaggttgg aacagcagca ctatacatga   1980

aatataaacc aaaaaccttt actgtttcta aatttcctag attgctatta tttggttgta   2040

agttgagtat tccacagaaa gtggtaatta tctcttctct cttcctccat tagaaaatta   2100

ggtaaataat ggattcctat aatgggagca tcaccactta ttaaaacaca catagaatga   2160

tgaattaaaa aagttttcta ggattgtctt ttattctgcc acatttattg ataaacagtg   2220

aaggaatttt taaaaaattt ttaagaattg tttgtcacgt catttttaga aatgttctac   2280

ctgtatatgg taatgtccag ttttaaaaat attggacatc ttcaatctta aacatttcta   2340

tttagctgat tggttctcac atatacttct aaaagaaact tttatgttat aagagttact   2400

ttttggataa gatttattaa tctcagttac ctactattct gacattttag gaaggaggta   2460

attgttttta atgatggata aacttgtgct ggtgttttgg atcttatgat gctgagcatg   2520

ttctgcactg gtgctaatgt ctaatataat tttatattta cacacatacg tgctacccag   2580

agattaattt agtccatatg aactattgac ccattgttca ttgagacagc aacatacgca   2640

ctcctaaatc agtgtgttta gacttttcaa gtatctaact catttccaaa catgtaccat   2700

gttttataaa cctcttgatt tccagcaaca tactatagaa aacacctgct actcaaaaca   2760

caacttctca gtgtcatcca ttgctgtcgt gagagacaac atagcaatat ctggtatgtt   2820

gcaagctttc aagatagcct gaacttaaaa agttggtgca ttagttgtat ctgatggata   2880

taaatttgcc tcctagttca ctttgtgtca agagctaaaa ctgtgaacct aactttctct   2940

tattggtggg taataactga aaataaagat ttattttcat gctcacttct taaaagtcat   3000

aaaaacaatc aaataggatc                                               3020


<210>  613
<211>  69
<212>  PRT
<213>  Homo sapiens

<400>  613


Met Asp His His Phe Arg Lys Pro Ala Asn Asp Ile Thr Ser Gln Leu 
1               5                   10                  15      


Glu Ile Asn Phe Gly Asp Leu Gly Arg Pro Gly Arg Gly Gly Arg Gly 
            20                  25                  30          


Gly Arg Gly Gly Arg Gly Arg Gly Gly Arg Pro Asn Arg Gly Ser Arg 
        35                  40                  45              


Thr Asp Lys Ser Ser Ala Ser Ala Pro Asp Val Asp Asp Pro Glu Ala 
    50                  55                  60                  


Phe Pro Ala Leu Ala 
65                  

<210>  614
<211>  3822
<212>  DNA
<213>  Homo sapiens

<400>  614
gttagccctg agcccgaggg ggcgtgagtg aaaccaaaga gcactttcgc gagtcagtta     60

cgccgtcacg gttttttggt ttcaaggtag ctgaagacct agagagttta agggtggcca    120

gagcaggtgg caggactccg cccaccacca cgcttccctt ccttcagccc gcacgcttca    180

ctcccctcat ggggtctcgc ctctcaggcg cgcgcgaaga gttgtcgcgc ggtgcgtcct    240

gggaattgta gtcccgacgc ggagagtcgc ctcaggagaa atgactctgg cctacatacc    300

ccacagtgcc ttgcggcgca ggccgctccc ggatgtgtgc ctggcgccgg aagagaagac    360

ggcccccctc tctcggcccg gccatcttgt gggaagagct gaagcaggcg ctcttggctc    420

ggcgcggccc gctgcaatcc gtggaggaac gcgccgccga gccaccatca tgcctgggca    480

cttacaggaa ggcttcggct gcgtggtcac caaccgattc gaccagttat ttgacgacga    540

atcggacccc ttcgaggtgc tgaaggcagc agagaacaag aaaaaagaag ccggcggggg    600

cggcgttggg ggccctgggg ccaagagcgc agctcaggcc gcggcccaga ccaactccaa    660

cgcggcaggc aaacagctgc gcaaggagtc ccagaaagac cgcaagaacc cgctgccccc    720

cagcgttggc gtggttgaca agaaagagga gacgcagccg cccgtggcgc ttaagaaaga    780

aggaataaga cgagttggaa gaagacctga tcaacaactt cagggtgaag ggaaaataat    840

tgatagaaga ccagaaaggc gaccacctcg tgaacgaaga ttcgaaaagc cacttgaaga    900

aaagggtgaa ggaggcgaat tttcagttga tagaccgatt attgaccgac ctattcgagg    960

tcgtggtggt cttggaagag gtcgaggggg ccgtggacgt ggaatgggcc gaggagatgg   1020

atttgattct cgtggcaaac gtgaatttga taggcatagt ggaagtgata gatctggcct   1080

gaagcacgag gacaaacgtg gaggtagcgg atctcacaac tggggaactg tcaaagacga   1140

attaactgac ttggatcaat caaatgtgac tgaggaaaca cctgaaggtg aagaacatca   1200

tccagtggca gacactgaaa ataaggagaa tgaagttgaa gaggtaaaag aggagggtcc   1260

aaaagagatg actttggatg agtggaaggc tattcaaaat aaggaccggg caaaagtaga   1320

atttaatatc cgaaaaccaa atgaaggtgc tgatgggcag tggaagaagg gatttgttct   1380

tcataaatca aagagtgaag aggctcatgc tgaagattcg gttatggacc atcatttccg   1440

gaagccagca aatgatataa cgtctcagct ggagatcaat tttggagacc ttggccgccc   1500

aggacgtggc ggcaggggag gacgaggtgg acgtgggcgt ggtgggcgcc caaaccgtgg   1560

cagcaggacc gacaagtcaa gtgcttctgc tcctgatgtg gatgacccag aggcattccc   1620

agctctggct taactggatg ccataagaca accctggttc ctttgtgaac ccttctgttc   1680

aaagcttttg catgcttaag gattccaaac gactaagaaa ttaaaaaaaa aaagactgtc   1740

attcatacca ttcacaccta aagactgaat tttatctgtt ttaaaaatga acttctcccg   1800

ctacacagaa gtaacaaata tggtagtcag ttttgtattt agaaatgtat tggtagcagg   1860

gatgttttca taattttcag agattatgca ttcttcatga atacttttgt attgctgctt   1920

gcaaatatgc atttccaaac ttgaaatata ggtgtgaaca gtgtgtacca gtttaaagct   1980

ttcacttcat ttgtgttttt taattaagga tttagaagtt cccccaatta caaactggtt   2040

ttaaatattg gacatactgg ttttaatacc tgctttgcat attcacacat ggtcaactgg   2100

gacatgttaa actttgattt gtcaaatttt atgctgtgtg gaatactaac tatatgtatt   2160

ttaacttagt tttaatattt tcatttttgg ggaaaaatct tttttcactt ctcatgatag   2220

ctgttatata tatatgctaa atctttatat acagaaatat cagtacttga acaaattcaa   2280

agcacatttg gtttattaac ccttgctcct tgcatggctc attaggttca aattataact   2340

gatttacatt ttcagctata tttacttttt aaatgcttga gtttcccatt ttaaaatcta   2400

aactagacat cttaattggt gaaagttgtt taaactactt attgttggta ggcacatcgt   2460

gtcaagtgaa gtagttttat aggtatgggt tttttctccc ccttcaccag ggtgggtgga   2520

ataagttgat ttggccaatg tgtaatattt aaactgttct gtaaaataag tgtctggcca   2580

tttggtatga tttctgtgtg tgaaaggtcc caaaatcaaa atggtacatc cataatcagc   2640

caccatttaa cccttccttg ttctaaaaca aaaaccaaag ggcgctggtt ggtagggtga   2700

ggtgggggag tattttaatt tttggaattt gggaagcaga cagctttact ttgtaaggtt   2760

ggaacagcag cactatacat gaaatataaa ccaaaaacct ttactgtttc taaatttcct   2820

agattgctat tatttggttg taagttgagt attccacaga aagtggtaat tatctcttct   2880

ctcttcctcc attagaaaat taggtaaata atggattcct ataatgggag catcaccact   2940

tattaaaaca cacatagaat gatgaattaa aaaagttttc taggattgtc ttttattctg   3000

ccacatttat tgataaacag tgaaggaatt tttaaaaaat ttttaagaat tgtttgtcac   3060

gtcattttta gaaatgttct acctgtatat ggtaatgtcc agttttaaaa atattggaca   3120

tcttcaatct taaacatttc tatttagctg attggttctc acatatactt ctaaaagaaa   3180

cttttatgtt ataagagtta ctttttggat aagatttatt aatctcagtt acctactatt   3240

ctgacatttt aggaaggagg taattgtttt taatgatgga taaacttgtg ctggtgtttt   3300

ggatcttatg atgctgagca tgttctgcac tggtgctaat gtctaatata attttatatt   3360

tacacacata cgtgctaccc agagattaat ttagtccata tgaactattg acccattgtt   3420

cattgagaca gcaacatacg cactcctaaa tcagtgtgtt tagacttttc aagtatctaa   3480

ctcatttcca aacatgtacc atgttttata aacctcttga tttccagcaa catactatag   3540

aaaacacctg ctactcaaaa cacaacttct cagtgtcatc cattgctgtc gtgagagaca   3600

acatagcaat atctggtatg ttgcaagctt tcaagatagc ctgaacttaa aaagttggtg   3660

cattagttgt atctgatgga tataaatttg cctcctagtt cactttgtgt caagagctaa   3720

aactgtgaac ctaactttct cttattggtg ggtaataact gaaaataaag atttattttc   3780

atgctcactt cttaaaagtc ataaaaacaa tcaaatagga tc                      3822


<210>  615
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  615


Met Thr Leu Ala Tyr Ile Pro His Ser Ala Leu Arg Arg Arg Pro Leu 
1               5                   10                  15      


Pro Asp Val Cys Leu Ala Pro Glu Glu Lys Thr Ala Pro Leu Ser Arg 
            20                  25                  30          


Pro Gly His Leu Val Gly Arg Ala Glu Ala Gly Ala Leu Gly Ser Ala 
        35                  40                  45              


Arg Pro Ala Ala Ile Arg Gly Gly Thr Arg Arg Arg Ala Thr Ile Met 
    50                  55                  60                  


Pro Gly His Leu Gln Glu Gly Phe Gly Cys Val Val Thr Asn Arg Phe 
65                  70                  75                  80  


Asp Gln Leu Phe Asp Asp Glu Ser Asp Pro Phe Glu Val Leu Lys Ala 
                85                  90                  95      


Ala Glu Asn Lys Lys Lys Glu Ala Gly Gly Gly Gly Val Gly Gly Pro 
            100                 105                 110         


Gly Ala Lys Ser Ala Ala Gln Ala Ala Ala Gln Thr Asn Ser Asn Ala 
        115                 120                 125             


Ala Gly Lys Gln Leu Arg Lys Glu Ser Gln Lys Asp Arg Lys Asn Pro 
    130                 135                 140                 


Leu Pro Pro Ser Val Gly Val Val Asp Lys Lys Glu Glu Thr Gln Pro 
145                 150                 155                 160 


Pro Val Ala Leu Lys Lys Glu Gly Ile Arg Arg Val Gly Arg Arg Pro 
                165                 170                 175     


Asp Gln Gln Leu Gln Gly Glu Gly Lys Ile Ile Asp Arg Arg Pro Glu 
            180                 185                 190         


Arg Arg Pro Pro Arg Glu Arg Arg Phe Glu Lys Pro Leu Glu Glu Lys 
        195                 200                 205             


Gly Glu Gly Gly Glu Phe Ser Val Asp Arg Pro Ile Ile Asp Arg Pro 
    210                 215                 220                 


Ile Arg Gly Arg Gly Gly Leu Gly Arg Gly Arg Gly Gly Arg Gly Arg 
225                 230                 235                 240 


Gly Met Gly Arg Gly Asp Gly Phe Asp Ser Arg Gly Lys Arg Glu Phe 
                245                 250                 255     


Asp Arg His Ser Gly Ser Asp Arg Ser Gly Leu Lys His Glu Asp Lys 
            260                 265                 270         


Arg Gly Gly Ser Gly Ser His Asn Trp Gly Thr Val Lys Asp Glu Leu 
        275                 280                 285             


Thr Asp Leu Asp Gln Ser Asn Val Thr Glu Glu Thr Pro Glu Gly Glu 
    290                 295                 300                 


Glu His His Pro Val Ala Asp Thr Glu Asn Lys Glu Asn Glu Val Glu 
305                 310                 315                 320 


Glu Val Lys Glu Glu Gly Pro Lys Glu Met Thr Leu Asp Glu Trp Lys 
                325                 330                 335     


Ala Ile Gln Asn Lys Asp Arg Ala Lys Val Glu Phe Asn Ile Arg Lys 
            340                 345                 350         


Pro Asn Glu Gly Ala Asp Gly Gln Trp Lys Lys Gly Phe Val Leu His 
        355                 360                 365             


Lys Ser Lys Ser Glu Glu Ala His Ala Glu Asp Ser Val Met Asp His 
    370                 375                 380                 


His Phe Arg Lys Pro Ala Asn Asp Ile Thr Ser Gln Leu Glu Ile Asn 
385                 390                 395                 400 


Phe Gly Asp Leu Gly Arg Pro Gly Arg Gly Gly Arg Gly Gly Arg Gly 
                405                 410                 415     


Gly Arg Gly Arg Gly Gly Arg Pro Asn Arg Gly Ser Arg Thr Asp Lys 
            420                 425                 430         


Ser Ser Ala Ser Ala Pro Asp Val Asp Asp Pro Glu Ala Phe Pro Ala 
        435                 440                 445             


Leu Ala 
    450 

<210>  616
<211>  3867
<212>  DNA
<213>  Homo sapiens

<400>  616
gttagccctg agcccgaggg ggcgtgagtg aaaccaaaga gcactttcgc gagtcagtta     60

cgccgtcacg gttttttggt ttcaaggtag ctgaagacct agagagttta agggtggcca    120

gagcaggtgg caggactccg cccaccacca cgcttccctt ccttcagccc gcacgcttca    180

ctcccctcat ggggtctcgc ctctcaggcg cgcgcgaaga gttgtcgcgc ggtgcgtcct    240

gggaattgta gtcccgacgc ggagagtcgc ctcaggagaa atgactctgg cctacatacc    300

ccacagtgcc ttgcggcgca ggccgctccc ggatgtgtgc ctggcgccgg aagagaagac    360

ggcccccctc tctcggcccg gccatcttgt gggaagagct gaagcaggcg ctcttggctc    420

ggcgcggccc gctgcaatcc gtggaggaac gcgccgccga gccaccatca tgcctgggca    480

cttacaggaa ggcttcggct gcgtggtcac caaccgattc gaccagttat ttgacgacga    540

atcggacccc ttcgaggtgc tgaaggcagc agagaacaag aaaaaagaag ccggcggggg    600

cggcgttggg ggccctgggg ccaagagcgc agctcaggcc gcggcccaga ccaactccaa    660

cgcggcaggc aaacagctgc gcaaggagtc ccagaaagac cgcaagaacc cgctgccccc    720

cagcgttggc gtggttgaca agaaagagga gacgcagccg cccgtggcgc ttaagaaaga    780

aggaataaga cgagttggaa gaagacctga tcaacaactt cagggtgaag ggaaaataat    840

tgatagaaga ccagaaaggc gaccacctcg tgaacgaaga ttcgaaaagc cacttgaaga    900

aaagggtgaa ggaggcgaat tttcagttga tagaccgatt attgaccgac ctattcgagg    960

tcgtggtggt cttggaagag gtcgaggggg ccgtggacgt ggaatgggcc gaggagatgg   1020

atttgattct cgtggcaaac gtgaatttga taggcatagt ggaagtgata gatctggcct   1080

gaagcacgag gacaaacgtg gaggtagcgg atctcacaac tggggaactg tcaaagacga   1140

attaacagag tcccccaaat acattcagaa acaaatatct tataattaca gtgacttgga   1200

tcaatcaaat gtgactgagg aaacacctga aggtgaagaa catcatccag tggcagacac   1260

tgaaaataag gagaatgaag ttgaagaggt aaaagaggag ggtccaaaag agatgacttt   1320

ggatgagtgg aaggctattc aaaataagga ccgggcaaaa gtagaattta atatccgaaa   1380

accaaatgaa ggtgctgatg ggcagtggaa gaagggattt gttcttcata aatcaaagag   1440

tgaagaggct catgctgaag attcggttat ggaccatcat ttccggaagc cagcaaatga   1500

tataacgtct cagctggaga tcaattttgg agaccttggc cgcccaggac gtggcggcag   1560

gggaggacga ggtggacgtg ggcgtggtgg gcgcccaaac cgtggcagca ggaccgacaa   1620

gtcaagtgct tctgctcctg atgtggatga cccagaggca ttcccagctc tggcttaact   1680

ggatgccata agacaaccct ggttcctttg tgaacccttc tgttcaaagc ttttgcatgc   1740

ttaaggattc caaacgacta agaaattaaa aaaaaaaaga ctgtcattca taccattcac   1800

acctaaagac tgaattttat ctgttttaaa aatgaacttc tcccgctaca cagaagtaac   1860

aaatatggta gtcagttttg tatttagaaa tgtattggta gcagggatgt tttcataatt   1920

ttcagagatt atgcattctt catgaatact tttgtattgc tgcttgcaaa tatgcatttc   1980

caaacttgaa atataggtgt gaacagtgtg taccagttta aagctttcac ttcatttgtg   2040

ttttttaatt aaggatttag aagttccccc aattacaaac tggttttaaa tattggacat   2100

actggtttta atacctgctt tgcatattca cacatggtca actgggacat gttaaacttt   2160

gatttgtcaa attttatgct gtgtggaata ctaactatat gtattttaac ttagttttaa   2220

tattttcatt tttggggaaa aatctttttt cacttctcat gatagctgtt atatatatat   2280

gctaaatctt tatatacaga aatatcagta cttgaacaaa ttcaaagcac atttggttta   2340

ttaacccttg ctccttgcat ggctcattag gttcaaatta taactgattt acattttcag   2400

ctatatttac tttttaaatg cttgagtttc ccattttaaa atctaaacta gacatcttaa   2460

ttggtgaaag ttgtttaaac tacttattgt tggtaggcac atcgtgtcaa gtgaagtagt   2520

tttataggta tgggtttttt ctcccccttc accagggtgg gtggaataag ttgatttggc   2580

caatgtgtaa tatttaaact gttctgtaaa ataagtgtct ggccatttgg tatgatttct   2640

gtgtgtgaaa ggtcccaaaa tcaaaatggt acatccataa tcagccacca tttaaccctt   2700

ccttgttcta aaacaaaaac caaagggcgc tggttggtag ggtgaggtgg gggagtattt   2760

taatttttgg aatttgggaa gcagacagct ttactttgta aggttggaac agcagcacta   2820

tacatgaaat ataaaccaaa aacctttact gtttctaaat ttcctagatt gctattattt   2880

ggttgtaagt tgagtattcc acagaaagtg gtaattatct cttctctctt cctccattag   2940

aaaattaggt aaataatgga ttcctataat gggagcatca ccacttatta aaacacacat   3000

agaatgatga attaaaaaag ttttctagga ttgtctttta ttctgccaca tttattgata   3060

aacagtgaag gaatttttaa aaaattttta agaattgttt gtcacgtcat ttttagaaat   3120

gttctacctg tatatggtaa tgtccagttt taaaaatatt ggacatcttc aatcttaaac   3180

atttctattt agctgattgg ttctcacata tacttctaaa agaaactttt atgttataag   3240

agttactttt tggataagat ttattaatct cagttaccta ctattctgac attttaggaa   3300

ggaggtaatt gtttttaatg atggataaac ttgtgctggt gttttggatc ttatgatgct   3360

gagcatgttc tgcactggtg ctaatgtcta atataatttt atatttacac acatacgtgc   3420

tacccagaga ttaatttagt ccatatgaac tattgaccca ttgttcattg agacagcaac   3480

atacgcactc ctaaatcagt gtgtttagac ttttcaagta tctaactcat ttccaaacat   3540

gtaccatgtt ttataaacct cttgatttcc agcaacatac tatagaaaac acctgctact   3600

caaaacacaa cttctcagtg tcatccattg ctgtcgtgag agacaacata gcaatatctg   3660

gtatgttgca agctttcaag atagcctgaa cttaaaaagt tggtgcatta gttgtatctg   3720

atggatataa atttgcctcc tagttcactt tgtgtcaaga gctaaaactg tgaacctaac   3780

tttctcttat tggtgggtaa taactgaaaa taaagattta ttttcatgct cacttcttaa   3840

aagtcataaa aacaatcaaa taggatc                                       3867


<210>  617
<211>  465
<212>  PRT
<213>  Homo sapiens

<400>  617


Met Thr Leu Ala Tyr Ile Pro His Ser Ala Leu Arg Arg Arg Pro Leu 
1               5                   10                  15      


Pro Asp Val Cys Leu Ala Pro Glu Glu Lys Thr Ala Pro Leu Ser Arg 
            20                  25                  30          


Pro Gly His Leu Val Gly Arg Ala Glu Ala Gly Ala Leu Gly Ser Ala 
        35                  40                  45              


Arg Pro Ala Ala Ile Arg Gly Gly Thr Arg Arg Arg Ala Thr Ile Met 
    50                  55                  60                  


Pro Gly His Leu Gln Glu Gly Phe Gly Cys Val Val Thr Asn Arg Phe 
65                  70                  75                  80  


Asp Gln Leu Phe Asp Asp Glu Ser Asp Pro Phe Glu Val Leu Lys Ala 
                85                  90                  95      


Ala Glu Asn Lys Lys Lys Glu Ala Gly Gly Gly Gly Val Gly Gly Pro 
            100                 105                 110         


Gly Ala Lys Ser Ala Ala Gln Ala Ala Ala Gln Thr Asn Ser Asn Ala 
        115                 120                 125             


Ala Gly Lys Gln Leu Arg Lys Glu Ser Gln Lys Asp Arg Lys Asn Pro 
    130                 135                 140                 


Leu Pro Pro Ser Val Gly Val Val Asp Lys Lys Glu Glu Thr Gln Pro 
145                 150                 155                 160 


Pro Val Ala Leu Lys Lys Glu Gly Ile Arg Arg Val Gly Arg Arg Pro 
                165                 170                 175     


Asp Gln Gln Leu Gln Gly Glu Gly Lys Ile Ile Asp Arg Arg Pro Glu 
            180                 185                 190         


Arg Arg Pro Pro Arg Glu Arg Arg Phe Glu Lys Pro Leu Glu Glu Lys 
        195                 200                 205             


Gly Glu Gly Gly Glu Phe Ser Val Asp Arg Pro Ile Ile Asp Arg Pro 
    210                 215                 220                 


Ile Arg Gly Arg Gly Gly Leu Gly Arg Gly Arg Gly Gly Arg Gly Arg 
225                 230                 235                 240 


Gly Met Gly Arg Gly Asp Gly Phe Asp Ser Arg Gly Lys Arg Glu Phe 
                245                 250                 255     


Asp Arg His Ser Gly Ser Asp Arg Ser Gly Leu Lys His Glu Asp Lys 
            260                 265                 270         


Arg Gly Gly Ser Gly Ser His Asn Trp Gly Thr Val Lys Asp Glu Leu 
        275                 280                 285             


Thr Glu Ser Pro Lys Tyr Ile Gln Lys Gln Ile Ser Tyr Asn Tyr Ser 
    290                 295                 300                 


Asp Leu Asp Gln Ser Asn Val Thr Glu Glu Thr Pro Glu Gly Glu Glu 
305                 310                 315                 320 


His His Pro Val Ala Asp Thr Glu Asn Lys Glu Asn Glu Val Glu Glu 
                325                 330                 335     


Val Lys Glu Glu Gly Pro Lys Glu Met Thr Leu Asp Glu Trp Lys Ala 
            340                 345                 350         


Ile Gln Asn Lys Asp Arg Ala Lys Val Glu Phe Asn Ile Arg Lys Pro 
        355                 360                 365             


Asn Glu Gly Ala Asp Gly Gln Trp Lys Lys Gly Phe Val Leu His Lys 
    370                 375                 380                 


Ser Lys Ser Glu Glu Ala His Ala Glu Asp Ser Val Met Asp His His 
385                 390                 395                 400 


Phe Arg Lys Pro Ala Asn Asp Ile Thr Ser Gln Leu Glu Ile Asn Phe 
                405                 410                 415     


Gly Asp Leu Gly Arg Pro Gly Arg Gly Gly Arg Gly Gly Arg Gly Gly 
            420                 425                 430         


Arg Gly Arg Gly Gly Arg Pro Asn Arg Gly Ser Arg Thr Asp Lys Ser 
        435                 440                 445             


Ser Ala Ser Ala Pro Asp Val Asp Asp Pro Glu Ala Phe Pro Ala Leu 
    450                 455                 460                 


Ala 
465 

<210>  618
<211>  1760
<212>  DNA
<213>  Homo sapiens

<400>  618
tgtgtagtgt ttcacttgaa tttgtagctc tccaatttgt gtagaaaaac gtagtggttg     60

tgtattaaca gaaaatgctt ctgagaagtt tatatctagt aaggtcttta ccctagttgt    120

agttggaaga gtgtagaaca gagtttttct ttctgagtgt tctttttaac ttcagtgtta    180

gtgctagtag taaccttata tgtcatctct ccagaggtct tcatcaagga ttcacatggc    240

agtcctgatc tgaagggcat atttaaaatg tacttgtcca gatttcactg ctaaagatta    300

tgattcagta ggtctaggat gggcttcagc cgtttgggtt gattgtgata gcatacatgt    360

ctttagttga ggactgctgg tattacctgc aattttgaga tagagaaaag tgcaggaaaa    420

tcttcctcca ggatcactaa agctgagccc tagcttgtta cctgtggagg cattgagaca    480

tttgttcaca gaaagtacag tttggatttt tggttttttt tagaagaaag ctcattattt    540

agaaattttg caatgttact tttctactaa taacacaatc atcttcactt atatttttag    600

gctcatgctg aagattcggt tatggaccat catttccgga agccagcaaa tgatataacg    660

tctcagctgg agatcaattt tggagacctt ggccgcccag gacgtggcgg caggggagga    720

cgaggtggac gtgggcgtgg tgggcgccca aaccgtggca gcaggaccga caagtcaagt    780

gcttctgctc ctgatgtgga tgacccagag gcattcccag ctctggctta actggatgcc    840

ataagacaac cctggttcct ttgtgaaccc ttctgttcaa agcttttgca tgcttaagga    900

ttccaaacga ctaagaaatt aaaaaaaaaa agactgtcat tcataccatt cacacctaaa    960

gactgaattt tatctgtttt aaaaatgaac ttctcccgct acacagaagt aacaaatatg   1020

gtagtcagtt ttgtatttag aaatgtattg gtagcaggga tgttttcata attttcagag   1080

attatgcatt cttcatgaat acttttgtat tgctgcttgc aaatatgcat ttccaaactt   1140

gaaatatagg tgtgaacagt gtgtaccagt ttaaagcttt cacttcattt gtgtttttta   1200

attaaggatt tagaagttcc cccaattaca aactggtttt aaatattgga catactggtt   1260

ttaatacctg ctttgcatat tcacacatgg tcaactggga catgttaaac tttgatttgt   1320

caaattttat gctgtgtgga atactaacta tatgtatttt aacttagttt taatattttc   1380

atttttgggg aaaaatcttt tttcacttct catgatagct gttatatata tatgctaaat   1440

ctttatatac agaaatatca gtacttgaac aaattcaaag cacatttggt ttattaaccc   1500

ttgctccttg catggctcat taggttcaaa ttataactga tttacatttt cagctatatt   1560

tactttttaa atgcttgagt ttcccatttt aaaatctaaa ctagacatct taattggtga   1620

aagttgttta aactacttat tgttggtagg cacatcgtgt caagtgaagt agttttatag   1680

gtatgggttt tttctccccc ttcaccaggg tgggtggaat aagttgattt ggccaatgtg   1740

taatatttaa actgttctgt                                               1760


<210>  619
<211>  69
<212>  PRT
<213>  Homo sapiens

<400>  619


Met Asp His His Phe Arg Lys Pro Ala Asn Asp Ile Thr Ser Gln Leu 
1               5                   10                  15      


Glu Ile Asn Phe Gly Asp Leu Gly Arg Pro Gly Arg Gly Gly Arg Gly 
            20                  25                  30          


Gly Arg Gly Gly Arg Gly Arg Gly Gly Arg Pro Asn Arg Gly Ser Arg 
        35                  40                  45              


Thr Asp Lys Ser Ser Ala Ser Ala Pro Asp Val Asp Asp Pro Glu Ala 
    50                  55                  60                  


Phe Pro Ala Leu Ala 
65                  

<210>  620
<211>  2562
<212>  DNA
<213>  Homo sapiens

<400>  620
gttagccctg agcccgaggg ggcgtgagtg aaaccaaaga gcactttcgc gagtcagtta     60

cgccgtcacg gttttttggt ttcaaggtag ctgaagacct agagagttta agggtggcca    120

gagcaggtgg caggactccg cccaccacca cgcttccctt ccttcagccc gcacgcttca    180

ctcccctcat ggggtctcgc ctctcaggcg cgcgcgaaga gttgtcgcgc ggtgcgtcct    240

gggaattgta gtcccgacgc ggagagtcgc ctcaggagaa atgactctgg cctacatacc    300

ccacagtgcc ttgcggcgca ggccgctccc ggatgtgtgc ctggcgccgg aagagaagac    360

ggcccccctc tctcggcccg gccatcttgt gggaagagct gaagcaggcg ctcttggctc    420

ggcgcggccc gctgcaatcc gtggaggaac gcgccgccga gccaccatca tgcctgggca    480

cttacaggaa ggcttcggct gcgtggtcac caaccgattc gaccagttat ttgacgacga    540

atcggacccc ttcgaggtgc tgaaggcagc agagaacaag aaaaaagaag ccggcggggg    600

cggcgttggg ggccctgggg ccaagagcgc agctcaggcc gcggcccaga ccaactccaa    660

cgcggcaggc aaacagctgc gcaaggagtc ccagaaagac cgcaagaacc cgctgccccc    720

cagcgttggc gtggttgaca agaaagagga gacgcagccg cccgtggcgc ttaagaaaga    780

aggaataaga cgagttggaa gaagacctga tcaacaactt cagggtgaag ggaaaataat    840

tgatagaaga ccagaaaggc gaccacctcg tgaacgaaga ttcgaaaagc cacttgaaga    900

aaagggtgaa ggaggcgaat tttcagttga tagaccgatt attgaccgac ctattcgagg    960

tcgtggtggt cttggaagag gtcgaggggg ccgtggacgt ggaatgggcc gaggagatgg   1020

atttgattct cgtggcaaac gtgaatttga taggcatagt ggaagtgata gatctggcct   1080

gaagcacgag gacaaacgtg gaggtagcgg atctcacaac tggggaactg tcaaagacga   1140

attaactgac ttggatcaat caaatgtgac tgaggaaaca cctgaaggtg aagaacatca   1200

tccagtggca gacactgaaa ataaggagaa tgaagttgaa gaggtaaaag aggagggtcc   1260

aaaagagatg actttggatg agtggaaggc tattcaaaat aaggaccggg caaaagtaga   1320

atttaatatc cgaaaaccaa atgaaggtgc tgatgggcag tggaagaagg gatttgttct   1380

tcataaatca aagagtgaag aggctcatgc tgaagattcg gttatggacc atcatttccg   1440

gaagccagca aatgatataa cgtctcagct ggagatcaat tttggagacc ttggccgccc   1500

aggacgtggc ggcaggggag gacgaggtgg acgtgggcgt ggtgggcgcc caaaccgtgg   1560

cagcaggacc gacaagtcaa gtgcttctgc tcctgatgtg gatgacccag aggcattccc   1620

agctctggct taactggatg ccataagaca accctggttc ctttgtgaac ccttctgttc   1680

aaagcttttg catgcttaag gattccaaac gactaagaaa ttaaaaaaaa aaagactgtc   1740

attcatacca ttcacaccta aagactgaat tttatctgtt ttaaaaatga acttctcccg   1800

ctacacagaa gtaacaaata tggtagtcag ttttgtattt agaaatgtat tggtagcagg   1860

gatgttttca taattttcag agattatgca ttcttcatga atacttttgt attgctgctt   1920

gcaaatatgc atttccaaac ttgaaatata ggtgtgaaca gtgtgtacca gtttaaagct   1980

ttcacttcat ttgtgttttt taattaagga tttagaagtt cccccaatta caaactggtt   2040

ttaaatattg gacatactgg ttttaatacc tgctttgcat attcacacat ggtcaactgg   2100

gacatgttaa actttgattt gtcaaatttt atgctgtgtg gaatactaac tatatgtatt   2160

ttaacttagt tttaatattt tcatttttgg ggaaaaatct tttttcactt ctcatgatag   2220

ctgttatata tatatgctaa atctttatat acagaaatat cagtacttga acaaattcaa   2280

agcacatttg gtttattaac ccttgctcct tgcatggctc attaggttca aattataact   2340

gatttacatt ttcagctata tttacttttt aaatgcttga gtttcccatt ttaaaatcta   2400

aactagacat cttaattggt gaaagttgtt taaactactt attgttggta ggcacatcgt   2460

gtcaagtgaa gtagttttat aggtatgggt tttttctccc ccttcaccag ggtgggtgga   2520

ataagttgat ttggccaatg tgtaatattt aaactgttct gt                      2562


<210>  621
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  621


Met Thr Leu Ala Tyr Ile Pro His Ser Ala Leu Arg Arg Arg Pro Leu 
1               5                   10                  15      


Pro Asp Val Cys Leu Ala Pro Glu Glu Lys Thr Ala Pro Leu Ser Arg 
            20                  25                  30          


Pro Gly His Leu Val Gly Arg Ala Glu Ala Gly Ala Leu Gly Ser Ala 
        35                  40                  45              


Arg Pro Ala Ala Ile Arg Gly Gly Thr Arg Arg Arg Ala Thr Ile Met 
    50                  55                  60                  


Pro Gly His Leu Gln Glu Gly Phe Gly Cys Val Val Thr Asn Arg Phe 
65                  70                  75                  80  


Asp Gln Leu Phe Asp Asp Glu Ser Asp Pro Phe Glu Val Leu Lys Ala 
                85                  90                  95      


Ala Glu Asn Lys Lys Lys Glu Ala Gly Gly Gly Gly Val Gly Gly Pro 
            100                 105                 110         


Gly Ala Lys Ser Ala Ala Gln Ala Ala Ala Gln Thr Asn Ser Asn Ala 
        115                 120                 125             


Ala Gly Lys Gln Leu Arg Lys Glu Ser Gln Lys Asp Arg Lys Asn Pro 
    130                 135                 140                 


Leu Pro Pro Ser Val Gly Val Val Asp Lys Lys Glu Glu Thr Gln Pro 
145                 150                 155                 160 


Pro Val Ala Leu Lys Lys Glu Gly Ile Arg Arg Val Gly Arg Arg Pro 
                165                 170                 175     


Asp Gln Gln Leu Gln Gly Glu Gly Lys Ile Ile Asp Arg Arg Pro Glu 
            180                 185                 190         


Arg Arg Pro Pro Arg Glu Arg Arg Phe Glu Lys Pro Leu Glu Glu Lys 
        195                 200                 205             


Gly Glu Gly Gly Glu Phe Ser Val Asp Arg Pro Ile Ile Asp Arg Pro 
    210                 215                 220                 


Ile Arg Gly Arg Gly Gly Leu Gly Arg Gly Arg Gly Gly Arg Gly Arg 
225                 230                 235                 240 


Gly Met Gly Arg Gly Asp Gly Phe Asp Ser Arg Gly Lys Arg Glu Phe 
                245                 250                 255     


Asp Arg His Ser Gly Ser Asp Arg Ser Gly Leu Lys His Glu Asp Lys 
            260                 265                 270         


Arg Gly Gly Ser Gly Ser His Asn Trp Gly Thr Val Lys Asp Glu Leu 
        275                 280                 285             


Thr Asp Leu Asp Gln Ser Asn Val Thr Glu Glu Thr Pro Glu Gly Glu 
    290                 295                 300                 


Glu His His Pro Val Ala Asp Thr Glu Asn Lys Glu Asn Glu Val Glu 
305                 310                 315                 320 


Glu Val Lys Glu Glu Gly Pro Lys Glu Met Thr Leu Asp Glu Trp Lys 
                325                 330                 335     


Ala Ile Gln Asn Lys Asp Arg Ala Lys Val Glu Phe Asn Ile Arg Lys 
            340                 345                 350         


Pro Asn Glu Gly Ala Asp Gly Gln Trp Lys Lys Gly Phe Val Leu His 
        355                 360                 365             


Lys Ser Lys Ser Glu Glu Ala His Ala Glu Asp Ser Val Met Asp His 
    370                 375                 380                 


His Phe Arg Lys Pro Ala Asn Asp Ile Thr Ser Gln Leu Glu Ile Asn 
385                 390                 395                 400 


Phe Gly Asp Leu Gly Arg Pro Gly Arg Gly Gly Arg Gly Gly Arg Gly 
                405                 410                 415     


Gly Arg Gly Arg Gly Gly Arg Pro Asn Arg Gly Ser Arg Thr Asp Lys 
            420                 425                 430         


Ser Ser Ala Ser Ala Pro Asp Val Asp Asp Pro Glu Ala Phe Pro Ala 
        435                 440                 445             


Leu Ala 
    450 

<210>  622
<211>  2607
<212>  DNA
<213>  Homo sapiens

<400>  622
gttagccctg agcccgaggg ggcgtgagtg aaaccaaaga gcactttcgc gagtcagtta     60

cgccgtcacg gttttttggt ttcaaggtag ctgaagacct agagagttta agggtggcca    120

gagcaggtgg caggactccg cccaccacca cgcttccctt ccttcagccc gcacgcttca    180

ctcccctcat ggggtctcgc ctctcaggcg cgcgcgaaga gttgtcgcgc ggtgcgtcct    240

gggaattgta gtcccgacgc ggagagtcgc ctcaggagaa atgactctgg cctacatacc    300

ccacagtgcc ttgcggcgca ggccgctccc ggatgtgtgc ctggcgccgg aagagaagac    360

ggcccccctc tctcggcccg gccatcttgt gggaagagct gaagcaggcg ctcttggctc    420

ggcgcggccc gctgcaatcc gtggaggaac gcgccgccga gccaccatca tgcctgggca    480

cttacaggaa ggcttcggct gcgtggtcac caaccgattc gaccagttat ttgacgacga    540

atcggacccc ttcgaggtgc tgaaggcagc agagaacaag aaaaaagaag ccggcggggg    600

cggcgttggg ggccctgggg ccaagagcgc agctcaggcc gcggcccaga ccaactccaa    660

cgcggcaggc aaacagctgc gcaaggagtc ccagaaagac cgcaagaacc cgctgccccc    720

cagcgttggc gtggttgaca agaaagagga gacgcagccg cccgtggcgc ttaagaaaga    780

aggaataaga cgagttggaa gaagacctga tcaacaactt cagggtgaag ggaaaataat    840

tgatagaaga ccagaaaggc gaccacctcg tgaacgaaga ttcgaaaagc cacttgaaga    900

aaagggtgaa ggaggcgaat tttcagttga tagaccgatt attgaccgac ctattcgagg    960

tcgtggtggt cttggaagag gtcgaggggg ccgtggacgt ggaatgggcc gaggagatgg   1020

atttgattct cgtggcaaac gtgaatttga taggcatagt ggaagtgata gatctggcct   1080

gaagcacgag gacaaacgtg gaggtagcgg atctcacaac tggggaactg tcaaagacga   1140

attaacagag tcccccaaat acattcagaa acaaatatct tataattaca gtgacttgga   1200

tcaatcaaat gtgactgagg aaacacctga aggtgaagaa catcatccag tggcagacac   1260

tgaaaataag gagaatgaag ttgaagaggt aaaagaggag ggtccaaaag agatgacttt   1320

ggatgagtgg aaggctattc aaaataagga ccgggcaaaa gtagaattta atatccgaaa   1380

accaaatgaa ggtgctgatg ggcagtggaa gaagggattt gttcttcata aatcaaagag   1440

tgaagaggct catgctgaag attcggttat ggaccatcat ttccggaagc cagcaaatga   1500

tataacgtct cagctggaga tcaattttgg agaccttggc cgcccaggac gtggcggcag   1560

gggaggacga ggtggacgtg ggcgtggtgg gcgcccaaac cgtggcagca ggaccgacaa   1620

gtcaagtgct tctgctcctg atgtggatga cccagaggca ttcccagctc tggcttaact   1680

ggatgccata agacaaccct ggttcctttg tgaacccttc tgttcaaagc ttttgcatgc   1740

ttaaggattc caaacgacta agaaattaaa aaaaaaaaga ctgtcattca taccattcac   1800

acctaaagac tgaattttat ctgttttaaa aatgaacttc tcccgctaca cagaagtaac   1860

aaatatggta gtcagttttg tatttagaaa tgtattggta gcagggatgt tttcataatt   1920

ttcagagatt atgcattctt catgaatact tttgtattgc tgcttgcaaa tatgcatttc   1980

caaacttgaa atataggtgt gaacagtgtg taccagttta aagctttcac ttcatttgtg   2040

ttttttaatt aaggatttag aagttccccc aattacaaac tggttttaaa tattggacat   2100

actggtttta atacctgctt tgcatattca cacatggtca actgggacat gttaaacttt   2160

gatttgtcaa attttatgct gtgtggaata ctaactatat gtattttaac ttagttttaa   2220

tattttcatt tttggggaaa aatctttttt cacttctcat gatagctgtt atatatatat   2280

gctaaatctt tatatacaga aatatcagta cttgaacaaa ttcaaagcac atttggttta   2340

ttaacccttg ctccttgcat ggctcattag gttcaaatta taactgattt acattttcag   2400

ctatatttac tttttaaatg cttgagtttc ccattttaaa atctaaacta gacatcttaa   2460

ttggtgaaag ttgtttaaac tacttattgt tggtaggcac atcgtgtcaa gtgaagtagt   2520

tttataggta tgggtttttt ctcccccttc accagggtgg gtggaataag ttgatttggc   2580

caatgtgtaa tatttaaact gttctgt                                       2607


<210>  623
<211>  465
<212>  PRT
<213>  Homo sapiens

<400>  623


Met Thr Leu Ala Tyr Ile Pro His Ser Ala Leu Arg Arg Arg Pro Leu 
1               5                   10                  15      


Pro Asp Val Cys Leu Ala Pro Glu Glu Lys Thr Ala Pro Leu Ser Arg 
            20                  25                  30          


Pro Gly His Leu Val Gly Arg Ala Glu Ala Gly Ala Leu Gly Ser Ala 
        35                  40                  45              


Arg Pro Ala Ala Ile Arg Gly Gly Thr Arg Arg Arg Ala Thr Ile Met 
    50                  55                  60                  


Pro Gly His Leu Gln Glu Gly Phe Gly Cys Val Val Thr Asn Arg Phe 
65                  70                  75                  80  


Asp Gln Leu Phe Asp Asp Glu Ser Asp Pro Phe Glu Val Leu Lys Ala 
                85                  90                  95      


Ala Glu Asn Lys Lys Lys Glu Ala Gly Gly Gly Gly Val Gly Gly Pro 
            100                 105                 110         


Gly Ala Lys Ser Ala Ala Gln Ala Ala Ala Gln Thr Asn Ser Asn Ala 
        115                 120                 125             


Ala Gly Lys Gln Leu Arg Lys Glu Ser Gln Lys Asp Arg Lys Asn Pro 
    130                 135                 140                 


Leu Pro Pro Ser Val Gly Val Val Asp Lys Lys Glu Glu Thr Gln Pro 
145                 150                 155                 160 


Pro Val Ala Leu Lys Lys Glu Gly Ile Arg Arg Val Gly Arg Arg Pro 
                165                 170                 175     


Asp Gln Gln Leu Gln Gly Glu Gly Lys Ile Ile Asp Arg Arg Pro Glu 
            180                 185                 190         


Arg Arg Pro Pro Arg Glu Arg Arg Phe Glu Lys Pro Leu Glu Glu Lys 
        195                 200                 205             


Gly Glu Gly Gly Glu Phe Ser Val Asp Arg Pro Ile Ile Asp Arg Pro 
    210                 215                 220                 


Ile Arg Gly Arg Gly Gly Leu Gly Arg Gly Arg Gly Gly Arg Gly Arg 
225                 230                 235                 240 


Gly Met Gly Arg Gly Asp Gly Phe Asp Ser Arg Gly Lys Arg Glu Phe 
                245                 250                 255     


Asp Arg His Ser Gly Ser Asp Arg Ser Gly Leu Lys His Glu Asp Lys 
            260                 265                 270         


Arg Gly Gly Ser Gly Ser His Asn Trp Gly Thr Val Lys Asp Glu Leu 
        275                 280                 285             


Thr Glu Ser Pro Lys Tyr Ile Gln Lys Gln Ile Ser Tyr Asn Tyr Ser 
    290                 295                 300                 


Asp Leu Asp Gln Ser Asn Val Thr Glu Glu Thr Pro Glu Gly Glu Glu 
305                 310                 315                 320 


His His Pro Val Ala Asp Thr Glu Asn Lys Glu Asn Glu Val Glu Glu 
                325                 330                 335     


Val Lys Glu Glu Gly Pro Lys Glu Met Thr Leu Asp Glu Trp Lys Ala 
            340                 345                 350         


Ile Gln Asn Lys Asp Arg Ala Lys Val Glu Phe Asn Ile Arg Lys Pro 
        355                 360                 365             


Asn Glu Gly Ala Asp Gly Gln Trp Lys Lys Gly Phe Val Leu His Lys 
    370                 375                 380                 


Ser Lys Ser Glu Glu Ala His Ala Glu Asp Ser Val Met Asp His His 
385                 390                 395                 400 


Phe Arg Lys Pro Ala Asn Asp Ile Thr Ser Gln Leu Glu Ile Asn Phe 
                405                 410                 415     


Gly Asp Leu Gly Arg Pro Gly Arg Gly Gly Arg Gly Gly Arg Gly Gly 
            420                 425                 430         


Arg Gly Arg Gly Gly Arg Pro Asn Arg Gly Ser Arg Thr Asp Lys Ser 
        435                 440                 445             


Ser Ala Ser Ala Pro Asp Val Asp Asp Pro Glu Ala Phe Pro Ala Leu 
    450                 455                 460                 


Ala 
465 

<210>  624
<211>  1476
<212>  DNA
<213>  Homo sapiens

<400>  624
tgtgtagtgt ttcacttgaa tttgtagctc tccaatttgt gtagaaaaac gtagtggttg     60

tgtattaaca gaaaatgctt ctgagaagtt tatatctagt aaggtcttta ccctagttgt    120

agttggaaga gtgtagaaca gagtttttct ttctgagtgt tctttttaac ttcagtgtta    180

gtgctagtag taaccttata tgtcatctct ccagaggtct tcatcaagga ttcacatggc    240

agtcctgatc tgaagggcat atttaaaatg tacttgtcca gatttcactg ctaaagatta    300

tgattcagta ggtctaggat gggcttcagc cgtttgggtt gattgtgata gcatacatgt    360

ctttagttga ggactgctgg tattacctgc aattttgaga tagagaaaag tgcaggaaaa    420

tcttcctcca ggatcactaa agctgagccc tagcttgtta cctgtggagg cattgagaca    480

tttgttcaca gaaagtacag tttggatttt tggttttttt tagaagaaag ctcattattt    540

agaaattttg caatgttact tttctactaa taacacaatc atcttcactt atatttttag    600

gctcatgctg aagattcggt tatggaccat catttccgga agccagcaaa tgatataacg    660

tctcagctgg agatcaattt tggagacctt ggccgcccag gacgtggcgg caggggagga    720

cgaggtggac gtgggcgtgg tgggcgccca aaccgtggca gcaggaccga caagtcaagt    780

gcttctgctc ctgatgtgga tgacccagag gcattcccag ctctggctta actggatgcc    840

ataagacaac cctggttcct ttgtgaaccc ttctgttcaa agcttttgca tgcttaagga    900

ttccaaacga ctaagaaatt aaaaaaaaaa agactgtcat tcataccatt cacacctaaa    960

gactgaattt tatctgtttt aaaaatgaac ttctcccgct acacagaagt aacaaatatg   1020

gtagtcagtt ttgtatttag aaatgtattg gtagcaggga tgttttcata attttcagag   1080

attatgcatt cttcatgaat acttttgtat tgctgcttgc aaatatgcat ttccaaactt   1140

gaaatatagg tgtgaacagt gtgtaccagt ttaaagcttt cacttcattt gtgtttttta   1200

attaaggatt tagaagttcc cccaattaca aactggtttt aaatattgga catactggtt   1260

ttaatacctg ctttgcatat tcacacatgg tcaactggga catgttaaac tttgatttgt   1320

caaattttat gctgtgtgga atactaacta tatgtatttt aacttagttt taatattttc   1380

atttttgggg aaaaatcttt tttcacttct catgatagct gttatatata tatgctaaat   1440

ctttatatac agaaatatca gtacttgaac aaattc                             1476


<210>  625
<211>  69
<212>  PRT
<213>  Homo sapiens

<400>  625


Met Asp His His Phe Arg Lys Pro Ala Asn Asp Ile Thr Ser Gln Leu 
1               5                   10                  15      


Glu Ile Asn Phe Gly Asp Leu Gly Arg Pro Gly Arg Gly Gly Arg Gly 
            20                  25                  30          


Gly Arg Gly Gly Arg Gly Arg Gly Gly Arg Pro Asn Arg Gly Ser Arg 
        35                  40                  45              


Thr Asp Lys Ser Ser Ala Ser Ala Pro Asp Val Asp Asp Pro Glu Ala 
    50                  55                  60                  


Phe Pro Ala Leu Ala 
65                  

<210>  626
<211>  2323
<212>  DNA
<213>  Homo sapiens

<400>  626
gttagccctg agcccgaggg ggcgtgagtg aaaccaaaga gcactttcgc gagtcagtta     60

cgccgtcacg gttttttggt ttcaaggtag ctgaagacct agagagttta agggtggcca    120

gagcaggtgg caggactccg cccaccacca cgcttccctt ccttcagccc gcacgcttca    180

ctcccctcat ggggtctcgc ctctcaggcg cgcgcgaaga gttgtcgcgc ggtgcgtcct    240

gggaattgta gtcccgacgc ggagagtcgc ctcaggagaa atgactctgg cctacatacc    300

ccacagtgcc ttgcggcgca ggccgctccc ggatgtgtgc ctggcgccgg aagagaagac    360

ggcccccctc tctcggcccg gccatcttgt gggaagagct gaagcaggcg ctcttggctc    420

ggcgcggccc gctgcaatcc gtggaggaac gcgccgccga gccaccatca tgcctgggca    480

cttacaggaa ggcttcggct gcgtggtcac caaccgattc gaccagttat ttgacgacga    540

atcggacccc ttcgaggtgc tgaaggcagc agagaacaag aaaaaagaag ccggcggggg    600

cggcgttggg ggccctgggg ccaagagcgc agctcaggcc gcggcccaga ccaactccaa    660

cgcggcaggc aaacagctgc gcaaggagtc ccagaaagac cgcaagaacc cgctgccccc    720

cagcgttggc gtggttgaca agaaagagga gacgcagccg cccgtggcgc ttaagaaaga    780

aggaataaga cgagttggaa gaagacctga tcaacaactt cagggtgaag ggaaaataat    840

tgatagaaga ccagaaaggc gaccacctcg tgaacgaaga ttcgaaaagc cacttgaaga    900

aaagggtgaa ggaggcgaat tttcagttga tagaccgatt attgaccgac ctattcgagg    960

tcgtggtggt cttggaagag gtcgaggggg ccgtggacgt ggaatgggcc gaggagatgg   1020

atttgattct cgtggcaaac gtgaatttga taggcatagt ggaagtgata gatctggcct   1080

gaagcacgag gacaaacgtg gaggtagcgg atctcacaac tggggaactg tcaaagacga   1140

attaacagag tcccccaaat acattcagaa acaaatatct tataattaca gtgacttgga   1200

tcaatcaaat gtgactgagg aaacacctga aggtgaagaa catcatccag tggcagacac   1260

tgaaaataag gagaatgaag ttgaagaggt aaaagaggag ggtccaaaag agatgacttt   1320

ggatgagtgg aaggctattc aaaataagga ccgggcaaaa gtagaattta atatccgaaa   1380

accaaatgaa ggtgctgatg ggcagtggaa gaagggattt gttcttcata aatcaaagag   1440

tgaagaggct catgctgaag attcggttat ggaccatcat ttccggaagc cagcaaatga   1500

tataacgtct cagctggaga tcaattttgg agaccttggc cgcccaggac gtggcggcag   1560

gggaggacga ggtggacgtg ggcgtggtgg gcgcccaaac cgtggcagca ggaccgacaa   1620

gtcaagtgct tctgctcctg atgtggatga cccagaggca ttcccagctc tggcttaact   1680

ggatgccata agacaaccct ggttcctttg tgaacccttc tgttcaaagc ttttgcatgc   1740

ttaaggattc caaacgacta agaaattaaa aaaaaaaaga ctgtcattca taccattcac   1800

acctaaagac tgaattttat ctgttttaaa aatgaacttc tcccgctaca cagaagtaac   1860

aaatatggta gtcagttttg tatttagaaa tgtattggta gcagggatgt tttcataatt   1920

ttcagagatt atgcattctt catgaatact tttgtattgc tgcttgcaaa tatgcatttc   1980

caaacttgaa atataggtgt gaacagtgtg taccagttta aagctttcac ttcatttgtg   2040

ttttttaatt aaggatttag aagttccccc aattacaaac tggttttaaa tattggacat   2100

actggtttta atacctgctt tgcatattca cacatggtca actgggacat gttaaacttt   2160

gatttgtcaa attttatgct gtgtggaata ctaactatat gtattttaac ttagttttaa   2220

tattttcatt tttggggaaa aatctttttt cacttctcat gatagctgtt atatatatat   2280

gctaaatctt tatatacaga aatatcagta cttgaacaaa ttc                     2323


<210>  627
<211>  465
<212>  PRT
<213>  Homo sapiens

<400>  627


Met Thr Leu Ala Tyr Ile Pro His Ser Ala Leu Arg Arg Arg Pro Leu 
1               5                   10                  15      


Pro Asp Val Cys Leu Ala Pro Glu Glu Lys Thr Ala Pro Leu Ser Arg 
            20                  25                  30          


Pro Gly His Leu Val Gly Arg Ala Glu Ala Gly Ala Leu Gly Ser Ala 
        35                  40                  45              


Arg Pro Ala Ala Ile Arg Gly Gly Thr Arg Arg Arg Ala Thr Ile Met 
    50                  55                  60                  


Pro Gly His Leu Gln Glu Gly Phe Gly Cys Val Val Thr Asn Arg Phe 
65                  70                  75                  80  


Asp Gln Leu Phe Asp Asp Glu Ser Asp Pro Phe Glu Val Leu Lys Ala 
                85                  90                  95      


Ala Glu Asn Lys Lys Lys Glu Ala Gly Gly Gly Gly Val Gly Gly Pro 
            100                 105                 110         


Gly Ala Lys Ser Ala Ala Gln Ala Ala Ala Gln Thr Asn Ser Asn Ala 
        115                 120                 125             


Ala Gly Lys Gln Leu Arg Lys Glu Ser Gln Lys Asp Arg Lys Asn Pro 
    130                 135                 140                 


Leu Pro Pro Ser Val Gly Val Val Asp Lys Lys Glu Glu Thr Gln Pro 
145                 150                 155                 160 


Pro Val Ala Leu Lys Lys Glu Gly Ile Arg Arg Val Gly Arg Arg Pro 
                165                 170                 175     


Asp Gln Gln Leu Gln Gly Glu Gly Lys Ile Ile Asp Arg Arg Pro Glu 
            180                 185                 190         


Arg Arg Pro Pro Arg Glu Arg Arg Phe Glu Lys Pro Leu Glu Glu Lys 
        195                 200                 205             


Gly Glu Gly Gly Glu Phe Ser Val Asp Arg Pro Ile Ile Asp Arg Pro 
    210                 215                 220                 


Ile Arg Gly Arg Gly Gly Leu Gly Arg Gly Arg Gly Gly Arg Gly Arg 
225                 230                 235                 240 


Gly Met Gly Arg Gly Asp Gly Phe Asp Ser Arg Gly Lys Arg Glu Phe 
                245                 250                 255     


Asp Arg His Ser Gly Ser Asp Arg Ser Gly Leu Lys His Glu Asp Lys 
            260                 265                 270         


Arg Gly Gly Ser Gly Ser His Asn Trp Gly Thr Val Lys Asp Glu Leu 
        275                 280                 285             


Thr Glu Ser Pro Lys Tyr Ile Gln Lys Gln Ile Ser Tyr Asn Tyr Ser 
    290                 295                 300                 


Asp Leu Asp Gln Ser Asn Val Thr Glu Glu Thr Pro Glu Gly Glu Glu 
305                 310                 315                 320 


His His Pro Val Ala Asp Thr Glu Asn Lys Glu Asn Glu Val Glu Glu 
                325                 330                 335     


Val Lys Glu Glu Gly Pro Lys Glu Met Thr Leu Asp Glu Trp Lys Ala 
            340                 345                 350         


Ile Gln Asn Lys Asp Arg Ala Lys Val Glu Phe Asn Ile Arg Lys Pro 
        355                 360                 365             


Asn Glu Gly Ala Asp Gly Gln Trp Lys Lys Gly Phe Val Leu His Lys 
    370                 375                 380                 


Ser Lys Ser Glu Glu Ala His Ala Glu Asp Ser Val Met Asp His His 
385                 390                 395                 400 


Phe Arg Lys Pro Ala Asn Asp Ile Thr Ser Gln Leu Glu Ile Asn Phe 
                405                 410                 415     


Gly Asp Leu Gly Arg Pro Gly Arg Gly Gly Arg Gly Gly Arg Gly Gly 
            420                 425                 430         


Arg Gly Arg Gly Gly Arg Pro Asn Arg Gly Ser Arg Thr Asp Lys Ser 
        435                 440                 445             


Ser Ala Ser Ala Pro Asp Val Asp Asp Pro Glu Ala Phe Pro Ala Leu 
    450                 455                 460                 


Ala 
465 

<210>  628
<211>  2278
<212>  DNA
<213>  Homo sapiens

<400>  628
gttagccctg agcccgaggg ggcgtgagtg aaaccaaaga gcactttcgc gagtcagtta     60

cgccgtcacg gttttttggt ttcaaggtag ctgaagacct agagagttta agggtggcca    120

gagcaggtgg caggactccg cccaccacca cgcttccctt ccttcagccc gcacgcttca    180

ctcccctcat ggggtctcgc ctctcaggcg cgcgcgaaga gttgtcgcgc ggtgcgtcct    240

gggaattgta gtcccgacgc ggagagtcgc ctcaggagaa atgactctgg cctacatacc    300

ccacagtgcc ttgcggcgca ggccgctccc ggatgtgtgc ctggcgccgg aagagaagac    360

ggcccccctc tctcggcccg gccatcttgt gggaagagct gaagcaggcg ctcttggctc    420

ggcgcggccc gctgcaatcc gtggaggaac gcgccgccga gccaccatca tgcctgggca    480

cttacaggaa ggcttcggct gcgtggtcac caaccgattc gaccagttat ttgacgacga    540

atcggacccc ttcgaggtgc tgaaggcagc agagaacaag aaaaaagaag ccggcggggg    600

cggcgttggg ggccctgggg ccaagagcgc agctcaggcc gcggcccaga ccaactccaa    660

cgcggcaggc aaacagctgc gcaaggagtc ccagaaagac cgcaagaacc cgctgccccc    720

cagcgttggc gtggttgaca agaaagagga gacgcagccg cccgtggcgc ttaagaaaga    780

aggaataaga cgagttggaa gaagacctga tcaacaactt cagggtgaag ggaaaataat    840

tgatagaaga ccagaaaggc gaccacctcg tgaacgaaga ttcgaaaagc cacttgaaga    900

aaagggtgaa ggaggcgaat tttcagttga tagaccgatt attgaccgac ctattcgagg    960

tcgtggtggt cttggaagag gtcgaggggg ccgtggacgt ggaatgggcc gaggagatgg   1020

atttgattct cgtggcaaac gtgaatttga taggcatagt ggaagtgata gatctggcct   1080

gaagcacgag gacaaacgtg gaggtagcgg atctcacaac tggggaactg tcaaagacga   1140

attaactgac ttggatcaat caaatgtgac tgaggaaaca cctgaaggtg aagaacatca   1200

tccagtggca gacactgaaa ataaggagaa tgaagttgaa gaggtaaaag aggagggtcc   1260

aaaagagatg actttggatg agtggaaggc tattcaaaat aaggaccggg caaaagtaga   1320

atttaatatc cgaaaaccaa atgaaggtgc tgatgggcag tggaagaagg gatttgttct   1380

tcataaatca aagagtgaag aggctcatgc tgaagattcg gttatggacc atcatttccg   1440

gaagccagca aatgatataa cgtctcagct ggagatcaat tttggagacc ttggccgccc   1500

aggacgtggc ggcaggggag gacgaggtgg acgtgggcgt ggtgggcgcc caaaccgtgg   1560

cagcaggacc gacaagtcaa gtgcttctgc tcctgatgtg gatgacccag aggcattccc   1620

agctctggct taactggatg ccataagaca accctggttc ctttgtgaac ccttctgttc   1680

aaagcttttg catgcttaag gattccaaac gactaagaaa ttaaaaaaaa aaagactgtc   1740

attcatacca ttcacaccta aagactgaat tttatctgtt ttaaaaatga acttctcccg   1800

ctacacagaa gtaacaaata tggtagtcag ttttgtattt agaaatgtat tggtagcagg   1860

gatgttttca taattttcag agattatgca ttcttcatga atacttttgt attgctgctt   1920

gcaaatatgc atttccaaac ttgaaatata ggtgtgaaca gtgtgtacca gtttaaagct   1980

ttcacttcat ttgtgttttt taattaagga tttagaagtt cccccaatta caaactggtt   2040

ttaaatattg gacatactgg ttttaatacc tgctttgcat attcacacat ggtcaactgg   2100

gacatgttaa actttgattt gtcaaatttt atgctgtgtg gaatactaac tatatgtatt   2160

ttaacttagt tttaatattt tcatttttgg ggaaaaatct tttttcactt ctcatgatag   2220

ctgttatata tatatgctaa atctttatat acagaaatat cagtacttga acaaattc     2278


<210>  629
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  629


Met Thr Leu Ala Tyr Ile Pro His Ser Ala Leu Arg Arg Arg Pro Leu 
1               5                   10                  15      


Pro Asp Val Cys Leu Ala Pro Glu Glu Lys Thr Ala Pro Leu Ser Arg 
            20                  25                  30          


Pro Gly His Leu Val Gly Arg Ala Glu Ala Gly Ala Leu Gly Ser Ala 
        35                  40                  45              


Arg Pro Ala Ala Ile Arg Gly Gly Thr Arg Arg Arg Ala Thr Ile Met 
    50                  55                  60                  


Pro Gly His Leu Gln Glu Gly Phe Gly Cys Val Val Thr Asn Arg Phe 
65                  70                  75                  80  


Asp Gln Leu Phe Asp Asp Glu Ser Asp Pro Phe Glu Val Leu Lys Ala 
                85                  90                  95      


Ala Glu Asn Lys Lys Lys Glu Ala Gly Gly Gly Gly Val Gly Gly Pro 
            100                 105                 110         


Gly Ala Lys Ser Ala Ala Gln Ala Ala Ala Gln Thr Asn Ser Asn Ala 
        115                 120                 125             


Ala Gly Lys Gln Leu Arg Lys Glu Ser Gln Lys Asp Arg Lys Asn Pro 
    130                 135                 140                 


Leu Pro Pro Ser Val Gly Val Val Asp Lys Lys Glu Glu Thr Gln Pro 
145                 150                 155                 160 


Pro Val Ala Leu Lys Lys Glu Gly Ile Arg Arg Val Gly Arg Arg Pro 
                165                 170                 175     


Asp Gln Gln Leu Gln Gly Glu Gly Lys Ile Ile Asp Arg Arg Pro Glu 
            180                 185                 190         


Arg Arg Pro Pro Arg Glu Arg Arg Phe Glu Lys Pro Leu Glu Glu Lys 
        195                 200                 205             


Gly Glu Gly Gly Glu Phe Ser Val Asp Arg Pro Ile Ile Asp Arg Pro 
    210                 215                 220                 


Ile Arg Gly Arg Gly Gly Leu Gly Arg Gly Arg Gly Gly Arg Gly Arg 
225                 230                 235                 240 


Gly Met Gly Arg Gly Asp Gly Phe Asp Ser Arg Gly Lys Arg Glu Phe 
                245                 250                 255     


Asp Arg His Ser Gly Ser Asp Arg Ser Gly Leu Lys His Glu Asp Lys 
            260                 265                 270         


Arg Gly Gly Ser Gly Ser His Asn Trp Gly Thr Val Lys Asp Glu Leu 
        275                 280                 285             


Thr Asp Leu Asp Gln Ser Asn Val Thr Glu Glu Thr Pro Glu Gly Glu 
    290                 295                 300                 


Glu His His Pro Val Ala Asp Thr Glu Asn Lys Glu Asn Glu Val Glu 
305                 310                 315                 320 


Glu Val Lys Glu Glu Gly Pro Lys Glu Met Thr Leu Asp Glu Trp Lys 
                325                 330                 335     


Ala Ile Gln Asn Lys Asp Arg Ala Lys Val Glu Phe Asn Ile Arg Lys 
            340                 345                 350         


Pro Asn Glu Gly Ala Asp Gly Gln Trp Lys Lys Gly Phe Val Leu His 
        355                 360                 365             


Lys Ser Lys Ser Glu Glu Ala His Ala Glu Asp Ser Val Met Asp His 
    370                 375                 380                 


His Phe Arg Lys Pro Ala Asn Asp Ile Thr Ser Gln Leu Glu Ile Asn 
385                 390                 395                 400 


Phe Gly Asp Leu Gly Arg Pro Gly Arg Gly Gly Arg Gly Gly Arg Gly 
                405                 410                 415     


Gly Arg Gly Arg Gly Gly Arg Pro Asn Arg Gly Ser Arg Thr Asp Lys 
            420                 425                 430         


Ser Ser Ala Ser Ala Pro Asp Val Asp Asp Pro Glu Ala Phe Pro Ala 
        435                 440                 445             


Leu Ala 
    450 

<210>  630
<211>  1172
<212>  DNA
<213>  Homo sapiens

<400>  630
tgtgtagtgt ttcacttgaa tttgtagctc tccaatttgt gtagaaaaac gtagtggttg     60

tgtattaaca gaaaatgctt ctgagaagtt tatatctagt aaggtcttta ccctagttgt    120

agttggaaga gtgtagaaca gagtttttct ttctgagtgt tctttttaac ttcagtgtta    180

gtgctagtag taaccttata tgtcatctct ccagaggtct tcatcaagga ttcacatggc    240

agtcctgatc tgaagggcat atttaaaatg tacttgtcca gatttcactg ctaaagatta    300

tgattcagta ggtctaggat gggcttcagc cgtttgggtt gattgtgata gcatacatgt    360

ctttagttga ggactgctgg tattacctgc aattttgaga tagagaaaag tgcaggaaaa    420

tcttcctcca ggatcactaa agctgagccc tagcttgtta cctgtggagg cattgagaca    480

tttgttcaca gaaagtacag tttggatttt tggttttttt tagaagaaag ctcattattt    540

agaaattttg caatgttact tttctactaa taacacaatc atcttcactt atatttttag    600

gctcatgctg aagattcggt tatggaccat catttccgga agccagcaaa tgatataacg    660

tctcagctgg agatcaattt tggagacctt ggccgcccag gacgtggcgg caggggagga    720

cgaggtggac gtgggcgtgg tgggcgccca aaccgtggca gcaggaccga caagtcaagt    780

gcttctgctc ctgatgtgga tgacccagag gcattcccag ctctggctta actggatgcc    840

ataagacaac cctggttcct ttgtgaaccc ttctgttcaa agcttttgca tgcttaagga    900

ttccaaacga ctaagaaatt aaaaaaaaaa agactgtcat tcataccatt cacacctaaa    960

gactgaattt tatctgtttt aaaaatgaac ttctcccgct acacagaagt aacaaatatg   1020

gtagtcagtt ttgtatttag aaatgtattg gtagcaggga tgttttcata attttcagag   1080

attatgcatt cttcatgaat acttttgtat tgctgcttgc aaatatgcat ttccaaactt   1140

gaaatatagg tgtgaacagt gtgtaccagt tt                                 1172


<210>  631
<211>  69
<212>  PRT
<213>  Homo sapiens

<400>  631


Met Asp His His Phe Arg Lys Pro Ala Asn Asp Ile Thr Ser Gln Leu 
1               5                   10                  15      


Glu Ile Asn Phe Gly Asp Leu Gly Arg Pro Gly Arg Gly Gly Arg Gly 
            20                  25                  30          


Gly Arg Gly Gly Arg Gly Arg Gly Gly Arg Pro Asn Arg Gly Ser Arg 
        35                  40                  45              


Thr Asp Lys Ser Ser Ala Ser Ala Pro Asp Val Asp Asp Pro Glu Ala 
    50                  55                  60                  


Phe Pro Ala Leu Ala 
65                  

<210>  632
<211>  2019
<212>  DNA
<213>  Homo sapiens

<400>  632
gttagccctg agcccgaggg ggcgtgagtg aaaccaaaga gcactttcgc gagtcagtta     60

cgccgtcacg gttttttggt ttcaaggtag ctgaagacct agagagttta agggtggcca    120

gagcaggtgg caggactccg cccaccacca cgcttccctt ccttcagccc gcacgcttca    180

ctcccctcat ggggtctcgc ctctcaggcg cgcgcgaaga gttgtcgcgc ggtgcgtcct    240

gggaattgta gtcccgacgc ggagagtcgc ctcaggagaa atgactctgg cctacatacc    300

ccacagtgcc ttgcggcgca ggccgctccc ggatgtgtgc ctggcgccgg aagagaagac    360

ggcccccctc tctcggcccg gccatcttgt gggaagagct gaagcaggcg ctcttggctc    420

ggcgcggccc gctgcaatcc gtggaggaac gcgccgccga gccaccatca tgcctgggca    480

cttacaggaa ggcttcggct gcgtggtcac caaccgattc gaccagttat ttgacgacga    540

atcggacccc ttcgaggtgc tgaaggcagc agagaacaag aaaaaagaag ccggcggggg    600

cggcgttggg ggccctgggg ccaagagcgc agctcaggcc gcggcccaga ccaactccaa    660

cgcggcaggc aaacagctgc gcaaggagtc ccagaaagac cgcaagaacc cgctgccccc    720

cagcgttggc gtggttgaca agaaagagga gacgcagccg cccgtggcgc ttaagaaaga    780

aggaataaga cgagttggaa gaagacctga tcaacaactt cagggtgaag ggaaaataat    840

tgatagaaga ccagaaaggc gaccacctcg tgaacgaaga ttcgaaaagc cacttgaaga    900

aaagggtgaa ggaggcgaat tttcagttga tagaccgatt attgaccgac ctattcgagg    960

tcgtggtggt cttggaagag gtcgaggggg ccgtggacgt ggaatgggcc gaggagatgg   1020

atttgattct cgtggcaaac gtgaatttga taggcatagt ggaagtgata gatctggcct   1080

gaagcacgag gacaaacgtg gaggtagcgg atctcacaac tggggaactg tcaaagacga   1140

attaacagag tcccccaaat acattcagaa acaaatatct tataattaca gtgacttgga   1200

tcaatcaaat gtgactgagg aaacacctga aggtgaagaa catcatccag tggcagacac   1260

tgaaaataag gagaatgaag ttgaagaggt aaaagaggag ggtccaaaag agatgacttt   1320

ggatgagtgg aaggctattc aaaataagga ccgggcaaaa gtagaattta atatccgaaa   1380

accaaatgaa ggtgctgatg ggcagtggaa gaagggattt gttcttcata aatcaaagag   1440

tgaagaggct catgctgaag attcggttat ggaccatcat ttccggaagc cagcaaatga   1500

tataacgtct cagctggaga tcaattttgg agaccttggc cgcccaggac gtggcggcag   1560

gggaggacga ggtggacgtg ggcgtggtgg gcgcccaaac cgtggcagca ggaccgacaa   1620

gtcaagtgct tctgctcctg atgtggatga cccagaggca ttcccagctc tggcttaact   1680

ggatgccata agacaaccct ggttcctttg tgaacccttc tgttcaaagc ttttgcatgc   1740

ttaaggattc caaacgacta agaaattaaa aaaaaaaaga ctgtcattca taccattcac   1800

acctaaagac tgaattttat ctgttttaaa aatgaacttc tcccgctaca cagaagtaac   1860

aaatatggta gtcagttttg tatttagaaa tgtattggta gcagggatgt tttcataatt   1920

ttcagagatt atgcattctt catgaatact tttgtattgc tgcttgcaaa tatgcatttc   1980

caaacttgaa atataggtgt gaacagtgtg taccagttt                          2019


<210>  633
<211>  465
<212>  PRT
<213>  Homo sapiens

<400>  633


Met Thr Leu Ala Tyr Ile Pro His Ser Ala Leu Arg Arg Arg Pro Leu 
1               5                   10                  15      


Pro Asp Val Cys Leu Ala Pro Glu Glu Lys Thr Ala Pro Leu Ser Arg 
            20                  25                  30          


Pro Gly His Leu Val Gly Arg Ala Glu Ala Gly Ala Leu Gly Ser Ala 
        35                  40                  45              


Arg Pro Ala Ala Ile Arg Gly Gly Thr Arg Arg Arg Ala Thr Ile Met 
    50                  55                  60                  


Pro Gly His Leu Gln Glu Gly Phe Gly Cys Val Val Thr Asn Arg Phe 
65                  70                  75                  80  


Asp Gln Leu Phe Asp Asp Glu Ser Asp Pro Phe Glu Val Leu Lys Ala 
                85                  90                  95      


Ala Glu Asn Lys Lys Lys Glu Ala Gly Gly Gly Gly Val Gly Gly Pro 
            100                 105                 110         


Gly Ala Lys Ser Ala Ala Gln Ala Ala Ala Gln Thr Asn Ser Asn Ala 
        115                 120                 125             


Ala Gly Lys Gln Leu Arg Lys Glu Ser Gln Lys Asp Arg Lys Asn Pro 
    130                 135                 140                 


Leu Pro Pro Ser Val Gly Val Val Asp Lys Lys Glu Glu Thr Gln Pro 
145                 150                 155                 160 


Pro Val Ala Leu Lys Lys Glu Gly Ile Arg Arg Val Gly Arg Arg Pro 
                165                 170                 175     


Asp Gln Gln Leu Gln Gly Glu Gly Lys Ile Ile Asp Arg Arg Pro Glu 
            180                 185                 190         


Arg Arg Pro Pro Arg Glu Arg Arg Phe Glu Lys Pro Leu Glu Glu Lys 
        195                 200                 205             


Gly Glu Gly Gly Glu Phe Ser Val Asp Arg Pro Ile Ile Asp Arg Pro 
    210                 215                 220                 


Ile Arg Gly Arg Gly Gly Leu Gly Arg Gly Arg Gly Gly Arg Gly Arg 
225                 230                 235                 240 


Gly Met Gly Arg Gly Asp Gly Phe Asp Ser Arg Gly Lys Arg Glu Phe 
                245                 250                 255     


Asp Arg His Ser Gly Ser Asp Arg Ser Gly Leu Lys His Glu Asp Lys 
            260                 265                 270         


Arg Gly Gly Ser Gly Ser His Asn Trp Gly Thr Val Lys Asp Glu Leu 
        275                 280                 285             


Thr Glu Ser Pro Lys Tyr Ile Gln Lys Gln Ile Ser Tyr Asn Tyr Ser 
    290                 295                 300                 


Asp Leu Asp Gln Ser Asn Val Thr Glu Glu Thr Pro Glu Gly Glu Glu 
305                 310                 315                 320 


His His Pro Val Ala Asp Thr Glu Asn Lys Glu Asn Glu Val Glu Glu 
                325                 330                 335     


Val Lys Glu Glu Gly Pro Lys Glu Met Thr Leu Asp Glu Trp Lys Ala 
            340                 345                 350         


Ile Gln Asn Lys Asp Arg Ala Lys Val Glu Phe Asn Ile Arg Lys Pro 
        355                 360                 365             


Asn Glu Gly Ala Asp Gly Gln Trp Lys Lys Gly Phe Val Leu His Lys 
    370                 375                 380                 


Ser Lys Ser Glu Glu Ala His Ala Glu Asp Ser Val Met Asp His His 
385                 390                 395                 400 


Phe Arg Lys Pro Ala Asn Asp Ile Thr Ser Gln Leu Glu Ile Asn Phe 
                405                 410                 415     


Gly Asp Leu Gly Arg Pro Gly Arg Gly Gly Arg Gly Gly Arg Gly Gly 
            420                 425                 430         


Arg Gly Arg Gly Gly Arg Pro Asn Arg Gly Ser Arg Thr Asp Lys Ser 
        435                 440                 445             


Ser Ala Ser Ala Pro Asp Val Asp Asp Pro Glu Ala Phe Pro Ala Leu 
    450                 455                 460                 


Ala 
465 

<210>  634
<211>  1974
<212>  DNA
<213>  Homo sapiens

<400>  634
gttagccctg agcccgaggg ggcgtgagtg aaaccaaaga gcactttcgc gagtcagtta     60

cgccgtcacg gttttttggt ttcaaggtag ctgaagacct agagagttta agggtggcca    120

gagcaggtgg caggactccg cccaccacca cgcttccctt ccttcagccc gcacgcttca    180

ctcccctcat ggggtctcgc ctctcaggcg cgcgcgaaga gttgtcgcgc ggtgcgtcct    240

gggaattgta gtcccgacgc ggagagtcgc ctcaggagaa atgactctgg cctacatacc    300

ccacagtgcc ttgcggcgca ggccgctccc ggatgtgtgc ctggcgccgg aagagaagac    360

ggcccccctc tctcggcccg gccatcttgt gggaagagct gaagcaggcg ctcttggctc    420

ggcgcggccc gctgcaatcc gtggaggaac gcgccgccga gccaccatca tgcctgggca    480

cttacaggaa ggcttcggct gcgtggtcac caaccgattc gaccagttat ttgacgacga    540

atcggacccc ttcgaggtgc tgaaggcagc agagaacaag aaaaaagaag ccggcggggg    600

cggcgttggg ggccctgggg ccaagagcgc agctcaggcc gcggcccaga ccaactccaa    660

cgcggcaggc aaacagctgc gcaaggagtc ccagaaagac cgcaagaacc cgctgccccc    720

cagcgttggc gtggttgaca agaaagagga gacgcagccg cccgtggcgc ttaagaaaga    780

aggaataaga cgagttggaa gaagacctga tcaacaactt cagggtgaag ggaaaataat    840

tgatagaaga ccagaaaggc gaccacctcg tgaacgaaga ttcgaaaagc cacttgaaga    900

aaagggtgaa ggaggcgaat tttcagttga tagaccgatt attgaccgac ctattcgagg    960

tcgtggtggt cttggaagag gtcgaggggg ccgtggacgt ggaatgggcc gaggagatgg   1020

atttgattct cgtggcaaac gtgaatttga taggcatagt ggaagtgata gatctggcct   1080

gaagcacgag gacaaacgtg gaggtagcgg atctcacaac tggggaactg tcaaagacga   1140

attaactgac ttggatcaat caaatgtgac tgaggaaaca cctgaaggtg aagaacatca   1200

tccagtggca gacactgaaa ataaggagaa tgaagttgaa gaggtaaaag aggagggtcc   1260

aaaagagatg actttggatg agtggaaggc tattcaaaat aaggaccggg caaaagtaga   1320

atttaatatc cgaaaaccaa atgaaggtgc tgatgggcag tggaagaagg gatttgttct   1380

tcataaatca aagagtgaag aggctcatgc tgaagattcg gttatggacc atcatttccg   1440

gaagccagca aatgatataa cgtctcagct ggagatcaat tttggagacc ttggccgccc   1500

aggacgtggc ggcaggggag gacgaggtgg acgtgggcgt ggtgggcgcc caaaccgtgg   1560

cagcaggacc gacaagtcaa gtgcttctgc tcctgatgtg gatgacccag aggcattccc   1620

agctctggct taactggatg ccataagaca accctggttc ctttgtgaac ccttctgttc   1680

aaagcttttg catgcttaag gattccaaac gactaagaaa ttaaaaaaaa aaagactgtc   1740

attcatacca ttcacaccta aagactgaat tttatctgtt ttaaaaatga acttctcccg   1800

ctacacagaa gtaacaaata tggtagtcag ttttgtattt agaaatgtat tggtagcagg   1860

gatgttttca taattttcag agattatgca ttcttcatga atacttttgt attgctgctt   1920

gcaaatatgc atttccaaac ttgaaatata ggtgtgaaca gtgtgtacca gttt         1974


<210>  635
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  635


Met Thr Leu Ala Tyr Ile Pro His Ser Ala Leu Arg Arg Arg Pro Leu 
1               5                   10                  15      


Pro Asp Val Cys Leu Ala Pro Glu Glu Lys Thr Ala Pro Leu Ser Arg 
            20                  25                  30          


Pro Gly His Leu Val Gly Arg Ala Glu Ala Gly Ala Leu Gly Ser Ala 
        35                  40                  45              


Arg Pro Ala Ala Ile Arg Gly Gly Thr Arg Arg Arg Ala Thr Ile Met 
    50                  55                  60                  


Pro Gly His Leu Gln Glu Gly Phe Gly Cys Val Val Thr Asn Arg Phe 
65                  70                  75                  80  


Asp Gln Leu Phe Asp Asp Glu Ser Asp Pro Phe Glu Val Leu Lys Ala 
                85                  90                  95      


Ala Glu Asn Lys Lys Lys Glu Ala Gly Gly Gly Gly Val Gly Gly Pro 
            100                 105                 110         


Gly Ala Lys Ser Ala Ala Gln Ala Ala Ala Gln Thr Asn Ser Asn Ala 
        115                 120                 125             


Ala Gly Lys Gln Leu Arg Lys Glu Ser Gln Lys Asp Arg Lys Asn Pro 
    130                 135                 140                 


Leu Pro Pro Ser Val Gly Val Val Asp Lys Lys Glu Glu Thr Gln Pro 
145                 150                 155                 160 


Pro Val Ala Leu Lys Lys Glu Gly Ile Arg Arg Val Gly Arg Arg Pro 
                165                 170                 175     


Asp Gln Gln Leu Gln Gly Glu Gly Lys Ile Ile Asp Arg Arg Pro Glu 
            180                 185                 190         


Arg Arg Pro Pro Arg Glu Arg Arg Phe Glu Lys Pro Leu Glu Glu Lys 
        195                 200                 205             


Gly Glu Gly Gly Glu Phe Ser Val Asp Arg Pro Ile Ile Asp Arg Pro 
    210                 215                 220                 


Ile Arg Gly Arg Gly Gly Leu Gly Arg Gly Arg Gly Gly Arg Gly Arg 
225                 230                 235                 240 


Gly Met Gly Arg Gly Asp Gly Phe Asp Ser Arg Gly Lys Arg Glu Phe 
                245                 250                 255     


Asp Arg His Ser Gly Ser Asp Arg Ser Gly Leu Lys His Glu Asp Lys 
            260                 265                 270         


Arg Gly Gly Ser Gly Ser His Asn Trp Gly Thr Val Lys Asp Glu Leu 
        275                 280                 285             


Thr Asp Leu Asp Gln Ser Asn Val Thr Glu Glu Thr Pro Glu Gly Glu 
    290                 295                 300                 


Glu His His Pro Val Ala Asp Thr Glu Asn Lys Glu Asn Glu Val Glu 
305                 310                 315                 320 


Glu Val Lys Glu Glu Gly Pro Lys Glu Met Thr Leu Asp Glu Trp Lys 
                325                 330                 335     


Ala Ile Gln Asn Lys Asp Arg Ala Lys Val Glu Phe Asn Ile Arg Lys 
            340                 345                 350         


Pro Asn Glu Gly Ala Asp Gly Gln Trp Lys Lys Gly Phe Val Leu His 
        355                 360                 365             


Lys Ser Lys Ser Glu Glu Ala His Ala Glu Asp Ser Val Met Asp His 
    370                 375                 380                 


His Phe Arg Lys Pro Ala Asn Asp Ile Thr Ser Gln Leu Glu Ile Asn 
385                 390                 395                 400 


Phe Gly Asp Leu Gly Arg Pro Gly Arg Gly Gly Arg Gly Gly Arg Gly 
                405                 410                 415     


Gly Arg Gly Arg Gly Gly Arg Pro Asn Arg Gly Ser Arg Thr Asp Lys 
            420                 425                 430         


Ser Ser Ala Ser Ala Pro Asp Val Asp Asp Pro Glu Ala Phe Pro Ala 
        435                 440                 445             


Leu Ala 
    450 

<210>  636
<211>  965
<212>  DNA
<213>  Homo sapiens

<400>  636
ctagaggatt accttcttgt atgttattaa gagttacata ttgtgggaat tatggaaatt     60

aaaaatgtgg tttaggagaa gataggctga ggattttaca taagagggta gtttttaaac    120

aaggtagtgt ttttaagaaa tgtgtatttt agtattcgta aagccagttc tagattgtat    180

tactgataaa tgatcattta agagttcata agtatgaatt ccatattcct tacttgtctc    240

taattagcaa acactgaatt cctggtctct accaagttgc ttagttacat aggaaactag    300

ggtaccctca tccttgaata atctttctct aaaagattac aaggttaatt ttctcaatta    360

aaatcataaa tttaaaatac ttttatgtaa tatcagctct ctaccaggta taaaacttga    420

aaaccttttc acagggagaa tgaagttgaa gaggtaaaag aggagggtcc aaaagagatg    480

actttggatg agtggaaggc tattcaaaat aaggaccggg caaaagtaga atttaatatc    540

cgaaaaccaa atgaaggtgc tgatgggcag tggaagaagg gatttgttct tcataaatca    600

aagagtgaag aggctcatgc tgaagattcg gttatggacc atcatttccg gaagccagca    660

aatgatataa cgtctcagct ggagatcaat tttggagacc ttggccgccc aggacgtggc    720

ggcaggggag gacgaggtgg acgtgggcgt ggtgggcgcc caaaccgtgg cagcaggacc    780

gacaagtcaa gtgcttctgc tcctgatgtg gatgacccag aggcattccc agctctggct    840

taactggatg ccataagaca accctggttc ctttgtgaac ccttctgttc aaagcttttg    900

catgcttaag gattccaaac gactaagaaa ttaaaaaaaa aaagactgtc attcatacca    960

ttcac                                                                965


<210>  637
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  637


Met Thr Leu Asp Glu Trp Lys Ala Ile Gln Asn Lys Asp Arg Ala Lys 
1               5                   10                  15      


Val Glu Phe Asn Ile Arg Lys Pro Asn Glu Gly Ala Asp Gly Gln Trp 
            20                  25                  30          


Lys Lys Gly Phe Val Leu His Lys Ser Lys Ser Glu Glu Ala His Ala 
        35                  40                  45              


Glu Asp Ser Val Met Asp His His Phe Arg Lys Pro Ala Asn Asp Ile 
    50                  55                  60                  


Thr Ser Gln Leu Glu Ile Asn Phe Gly Asp Leu Gly Arg Pro Gly Arg 
65                  70                  75                  80  


Gly Gly Arg Gly Gly Arg Gly Gly Arg Gly Arg Gly Gly Arg Pro Asn 
                85                  90                  95      


Arg Gly Ser Arg Thr Asp Lys Ser Ser Ala Ser Ala Pro Asp Val Asp 
            100                 105                 110         


Asp Pro Glu Ala Phe Pro Ala Leu Ala 
        115                 120     

<210>  638
<211>  1799
<212>  DNA
<213>  Homo sapiens

<400>  638
gttagccctg agcccgaggg ggcgtgagtg aaaccaaaga gcactttcgc gagtcagtta     60

cgccgtcacg gttttttggt ttcaaggtag ctgaagacct agagagttta agggtggcca    120

gagcaggtgg caggactccg cccaccacca cgcttccctt ccttcagccc gcacgcttca    180

ctcccctcat ggggtctcgc ctctcaggcg cgcgcgaaga gttgtcgcgc ggtgcgtcct    240

gggaattgta gtcccgacgc ggagagtcgc ctcaggagaa atgactctgg cctacatacc    300

ccacagtgcc ttgcggcgca ggccgctccc ggatgtgtgc ctggcgccgg aagagaagac    360

ggcccccctc tctcggcccg gccatcttgt gggaagagct gaagcaggcg ctcttggctc    420

ggcgcggccc gctgcaatcc gtggaggaac gcgccgccga gccaccatca tgcctgggca    480

cttacaggaa ggcttcggct gcgtggtcac caaccgattc gaccagttat ttgacgacga    540

atcggacccc ttcgaggtgc tgaaggcagc agagaacaag aaaaaagaag ccggcggggg    600

cggcgttggg ggccctgggg ccaagagcgc agctcaggcc gcggcccaga ccaactccaa    660

cgcggcaggc aaacagctgc gcaaggagtc ccagaaagac cgcaagaacc cgctgccccc    720

cagcgttggc gtggttgaca agaaagagga gacgcagccg cccgtggcgc ttaagaaaga    780

aggaataaga cgagttggaa gaagacctga tcaacaactt cagggtgaag ggaaaataat    840

tgatagaaga ccagaaaggc gaccacctcg tgaacgaaga ttcgaaaagc cacttgaaga    900

aaagggtgaa ggaggcgaat tttcagttga tagaccgatt attgaccgac ctattcgagg    960

tcgtggtggt cttggaagag gtcgaggggg ccgtggacgt ggaatgggcc gaggagatgg   1020

atttgattct cgtggcaaac gtgaatttga taggcatagt ggaagtgata gatctggcct   1080

gaagcacgag gacaaacgtg gaggtagcgg atctcacaac tggggaactg tcaaagacga   1140

attaacagag tcccccaaat acattcagaa acaaatatct tataattaca gtgacttgga   1200

tcaatcaaat gtgactgagg aaacacctga aggtgaagaa catcatccag tggcagacac   1260

tgaaaataag gagaatgaag ttgaagaggt aaaagaggag ggtccaaaag agatgacttt   1320

ggatgagtgg aaggctattc aaaataagga ccgggcaaaa gtagaattta atatccgaaa   1380

accaaatgaa ggtgctgatg ggcagtggaa gaagggattt gttcttcata aatcaaagag   1440

tgaagaggct catgctgaag attcggttat ggaccatcat ttccggaagc cagcaaatga   1500

tataacgtct cagctggaga tcaattttgg agaccttggc cgcccaggac gtggcggcag   1560

gggaggacga ggtggacgtg ggcgtggtgg gcgcccaaac cgtggcagca ggaccgacaa   1620

gtcaagtgct tctgctcctg atgtggatga cccagaggca ttcccagctc tggcttaact   1680

ggatgccata agacaaccct ggttcctttg tgaacccttc tgttcaaagc ttttgcatgc   1740

ttaaggattc caaacgacta agaaattaaa aaaaaaaaga ctgtcattca taccattca    1799


<210>  639
<211>  465
<212>  PRT
<213>  Homo sapiens

<400>  639


Met Thr Leu Ala Tyr Ile Pro His Ser Ala Leu Arg Arg Arg Pro Leu 
1               5                   10                  15      


Pro Asp Val Cys Leu Ala Pro Glu Glu Lys Thr Ala Pro Leu Ser Arg 
            20                  25                  30          


Pro Gly His Leu Val Gly Arg Ala Glu Ala Gly Ala Leu Gly Ser Ala 
        35                  40                  45              


Arg Pro Ala Ala Ile Arg Gly Gly Thr Arg Arg Arg Ala Thr Ile Met 
    50                  55                  60                  


Pro Gly His Leu Gln Glu Gly Phe Gly Cys Val Val Thr Asn Arg Phe 
65                  70                  75                  80  


Asp Gln Leu Phe Asp Asp Glu Ser Asp Pro Phe Glu Val Leu Lys Ala 
                85                  90                  95      


Ala Glu Asn Lys Lys Lys Glu Ala Gly Gly Gly Gly Val Gly Gly Pro 
            100                 105                 110         


Gly Ala Lys Ser Ala Ala Gln Ala Ala Ala Gln Thr Asn Ser Asn Ala 
        115                 120                 125             


Ala Gly Lys Gln Leu Arg Lys Glu Ser Gln Lys Asp Arg Lys Asn Pro 
    130                 135                 140                 


Leu Pro Pro Ser Val Gly Val Val Asp Lys Lys Glu Glu Thr Gln Pro 
145                 150                 155                 160 


Pro Val Ala Leu Lys Lys Glu Gly Ile Arg Arg Val Gly Arg Arg Pro 
                165                 170                 175     


Asp Gln Gln Leu Gln Gly Glu Gly Lys Ile Ile Asp Arg Arg Pro Glu 
            180                 185                 190         


Arg Arg Pro Pro Arg Glu Arg Arg Phe Glu Lys Pro Leu Glu Glu Lys 
        195                 200                 205             


Gly Glu Gly Gly Glu Phe Ser Val Asp Arg Pro Ile Ile Asp Arg Pro 
    210                 215                 220                 


Ile Arg Gly Arg Gly Gly Leu Gly Arg Gly Arg Gly Gly Arg Gly Arg 
225                 230                 235                 240 


Gly Met Gly Arg Gly Asp Gly Phe Asp Ser Arg Gly Lys Arg Glu Phe 
                245                 250                 255     


Asp Arg His Ser Gly Ser Asp Arg Ser Gly Leu Lys His Glu Asp Lys 
            260                 265                 270         


Arg Gly Gly Ser Gly Ser His Asn Trp Gly Thr Val Lys Asp Glu Leu 
        275                 280                 285             


Thr Glu Ser Pro Lys Tyr Ile Gln Lys Gln Ile Ser Tyr Asn Tyr Ser 
    290                 295                 300                 


Asp Leu Asp Gln Ser Asn Val Thr Glu Glu Thr Pro Glu Gly Glu Glu 
305                 310                 315                 320 


His His Pro Val Ala Asp Thr Glu Asn Lys Glu Asn Glu Val Glu Glu 
                325                 330                 335     


Val Lys Glu Glu Gly Pro Lys Glu Met Thr Leu Asp Glu Trp Lys Ala 
            340                 345                 350         


Ile Gln Asn Lys Asp Arg Ala Lys Val Glu Phe Asn Ile Arg Lys Pro 
        355                 360                 365             


Asn Glu Gly Ala Asp Gly Gln Trp Lys Lys Gly Phe Val Leu His Lys 
    370                 375                 380                 


Ser Lys Ser Glu Glu Ala His Ala Glu Asp Ser Val Met Asp His His 
385                 390                 395                 400 


Phe Arg Lys Pro Ala Asn Asp Ile Thr Ser Gln Leu Glu Ile Asn Phe 
                405                 410                 415     


Gly Asp Leu Gly Arg Pro Gly Arg Gly Gly Arg Gly Gly Arg Gly Gly 
            420                 425                 430         


Arg Gly Arg Gly Gly Arg Pro Asn Arg Gly Ser Arg Thr Asp Lys Ser 
        435                 440                 445             


Ser Ala Ser Ala Pro Asp Val Asp Asp Pro Glu Ala Phe Pro Ala Leu 
    450                 455                 460                 


Ala 
465 

<210>  640
<211>  1754
<212>  DNA
<213>  Homo sapiens

<400>  640
gttagccctg agcccgaggg ggcgtgagtg aaaccaaaga gcactttcgc gagtcagtta     60

cgccgtcacg gttttttggt ttcaaggtag ctgaagacct agagagttta agggtggcca    120

gagcaggtgg caggactccg cccaccacca cgcttccctt ccttcagccc gcacgcttca    180

ctcccctcat ggggtctcgc ctctcaggcg cgcgcgaaga gttgtcgcgc ggtgcgtcct    240

gggaattgta gtcccgacgc ggagagtcgc ctcaggagaa atgactctgg cctacatacc    300

ccacagtgcc ttgcggcgca ggccgctccc ggatgtgtgc ctggcgccgg aagagaagac    360

ggcccccctc tctcggcccg gccatcttgt gggaagagct gaagcaggcg ctcttggctc    420

ggcgcggccc gctgcaatcc gtggaggaac gcgccgccga gccaccatca tgcctgggca    480

cttacaggaa ggcttcggct gcgtggtcac caaccgattc gaccagttat ttgacgacga    540

atcggacccc ttcgaggtgc tgaaggcagc agagaacaag aaaaaagaag ccggcggggg    600

cggcgttggg ggccctgggg ccaagagcgc agctcaggcc gcggcccaga ccaactccaa    660

cgcggcaggc aaacagctgc gcaaggagtc ccagaaagac cgcaagaacc cgctgccccc    720

cagcgttggc gtggttgaca agaaagagga gacgcagccg cccgtggcgc ttaagaaaga    780

aggaataaga cgagttggaa gaagacctga tcaacaactt cagggtgaag ggaaaataat    840

tgatagaaga ccagaaaggc gaccacctcg tgaacgaaga ttcgaaaagc cacttgaaga    900

aaagggtgaa ggaggcgaat tttcagttga tagaccgatt attgaccgac ctattcgagg    960

tcgtggtggt cttggaagag gtcgaggggg ccgtggacgt ggaatgggcc gaggagatgg   1020

atttgattct cgtggcaaac gtgaatttga taggcatagt ggaagtgata gatctggcct   1080

gaagcacgag gacaaacgtg gaggtagcgg atctcacaac tggggaactg tcaaagacga   1140

attaactgac ttggatcaat caaatgtgac tgaggaaaca cctgaaggtg aagaacatca   1200

tccagtggca gacactgaaa ataaggagaa tgaagttgaa gaggtaaaag aggagggtcc   1260

aaaagagatg actttggatg agtggaaggc tattcaaaat aaggaccggg caaaagtaga   1320

atttaatatc cgaaaaccaa atgaaggtgc tgatgggcag tggaagaagg gatttgttct   1380

tcataaatca aagagtgaag aggctcatgc tgaagattcg gttatggacc atcatttccg   1440

gaagccagca aatgatataa cgtctcagct ggagatcaat tttggagacc ttggccgccc   1500

aggacgtggc ggcaggggag gacgaggtgg acgtgggcgt ggtgggcgcc caaaccgtgg   1560

cagcaggacc gacaagtcaa gtgcttctgc tcctgatgtg gatgacccag aggcattccc   1620

agctctggct taactggatg ccataagaca accctggttc ctttgtgaac ccttctgttc   1680

aaagcttttg catgcttaag gattccaaac gactaagaaa ttaaaaaaaa aaagactgtc   1740

attcatacca ttca                                                     1754


<210>  641
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  641


Met Thr Leu Ala Tyr Ile Pro His Ser Ala Leu Arg Arg Arg Pro Leu 
1               5                   10                  15      


Pro Asp Val Cys Leu Ala Pro Glu Glu Lys Thr Ala Pro Leu Ser Arg 
            20                  25                  30          


Pro Gly His Leu Val Gly Arg Ala Glu Ala Gly Ala Leu Gly Ser Ala 
        35                  40                  45              


Arg Pro Ala Ala Ile Arg Gly Gly Thr Arg Arg Arg Ala Thr Ile Met 
    50                  55                  60                  


Pro Gly His Leu Gln Glu Gly Phe Gly Cys Val Val Thr Asn Arg Phe 
65                  70                  75                  80  


Asp Gln Leu Phe Asp Asp Glu Ser Asp Pro Phe Glu Val Leu Lys Ala 
                85                  90                  95      


Ala Glu Asn Lys Lys Lys Glu Ala Gly Gly Gly Gly Val Gly Gly Pro 
            100                 105                 110         


Gly Ala Lys Ser Ala Ala Gln Ala Ala Ala Gln Thr Asn Ser Asn Ala 
        115                 120                 125             


Ala Gly Lys Gln Leu Arg Lys Glu Ser Gln Lys Asp Arg Lys Asn Pro 
    130                 135                 140                 


Leu Pro Pro Ser Val Gly Val Val Asp Lys Lys Glu Glu Thr Gln Pro 
145                 150                 155                 160 


Pro Val Ala Leu Lys Lys Glu Gly Ile Arg Arg Val Gly Arg Arg Pro 
                165                 170                 175     


Asp Gln Gln Leu Gln Gly Glu Gly Lys Ile Ile Asp Arg Arg Pro Glu 
            180                 185                 190         


Arg Arg Pro Pro Arg Glu Arg Arg Phe Glu Lys Pro Leu Glu Glu Lys 
        195                 200                 205             


Gly Glu Gly Gly Glu Phe Ser Val Asp Arg Pro Ile Ile Asp Arg Pro 
    210                 215                 220                 


Ile Arg Gly Arg Gly Gly Leu Gly Arg Gly Arg Gly Gly Arg Gly Arg 
225                 230                 235                 240 


Gly Met Gly Arg Gly Asp Gly Phe Asp Ser Arg Gly Lys Arg Glu Phe 
                245                 250                 255     


Asp Arg His Ser Gly Ser Asp Arg Ser Gly Leu Lys His Glu Asp Lys 
            260                 265                 270         


Arg Gly Gly Ser Gly Ser His Asn Trp Gly Thr Val Lys Asp Glu Leu 
        275                 280                 285             


Thr Asp Leu Asp Gln Ser Asn Val Thr Glu Glu Thr Pro Glu Gly Glu 
    290                 295                 300                 


Glu His His Pro Val Ala Asp Thr Glu Asn Lys Glu Asn Glu Val Glu 
305                 310                 315                 320 


Glu Val Lys Glu Glu Gly Pro Lys Glu Met Thr Leu Asp Glu Trp Lys 
                325                 330                 335     


Ala Ile Gln Asn Lys Asp Arg Ala Lys Val Glu Phe Asn Ile Arg Lys 
            340                 345                 350         


Pro Asn Glu Gly Ala Asp Gly Gln Trp Lys Lys Gly Phe Val Leu His 
        355                 360                 365             


Lys Ser Lys Ser Glu Glu Ala His Ala Glu Asp Ser Val Met Asp His 
    370                 375                 380                 


His Phe Arg Lys Pro Ala Asn Asp Ile Thr Ser Gln Leu Glu Ile Asn 
385                 390                 395                 400 


Phe Gly Asp Leu Gly Arg Pro Gly Arg Gly Gly Arg Gly Gly Arg Gly 
                405                 410                 415     


Gly Arg Gly Arg Gly Gly Arg Pro Asn Arg Gly Ser Arg Thr Asp Lys 
            420                 425                 430         


Ser Ser Ala Ser Ala Pro Asp Val Asp Asp Pro Glu Ala Phe Pro Ala 
        435                 440                 445             


Leu Ala 
    450 

<210>  642
<211>  1722
<212>  DNA
<213>  Homo sapiens

<400>  642
gttagccctg agcccgaggg ggcgtgagtg aaaccaaaga gcactttcgc gagtcagtta     60

cgccgtcacg gttttttggt ttcaaggtag ctgaagacct agagagttta agggtggcca    120

gagcaggtgg caggactccg cccaccacca cgcttccctt ccttcagccc gcacgcttca    180

ctcccctcat ggggtctcgc ctctcaggcg cgcgcgaaga gttgtcgcgc ggtgcgtcct    240

gggaattgta gtcccgacgc ggagagtcgc ctcaggagaa atgactctgg cctacatacc    300

ccacagtgcc ttgcggcgca ggccgctccc ggatgtgtgc ctggcgccgg aagagaagac    360

ggcccccctc tctcggcccg gccatcttgt gggaagagct gaagcaggcg ctcttggctc    420

ggcgcggccc gctgcaatcc gtggaggaac gcgccgccga gccaccatca tgcctgggca    480

cttacaggaa ggcttcggct gcgtggtcac caaccgattc gaccagttat ttgacgacga    540

atcggacccc ttcgaggtgc tgaaggcagc agagaacaag aaaaaagaag ccggcggggg    600

cggcgttggg ggccctgggg ccaagagcgc agctcaggcc gcggcccaga ccaactccaa    660

cgcggcaggc aaacagctgc gcaaggagtc ccagaaagac cgcaagaacc cgctgccccc    720

cagcgttggc gtggttgaca agaaagagga gacgcagccg cccgtggcgc ttaagaaaga    780

aggaataaga cgagttggaa gaagacctga tcaacaactt cagggtgaag ggaaaataat    840

tgatagaaga ccagaaaggc gaccacctcg tgaacgaaga ttcgaaaagc cacttgaaga    900

aaagggtgaa ggaggcgaat tttcagttga tagaccgatt attgaccgac ctattcgagg    960

tcgtggtggt cttggaagag gtcgaggggg ccgtggacgt ggaatgggcc gaggagatgg   1020

atttgattct cgtggcaaac gtgaatttga taggcatagt ggaagtgata gatctggcct   1080

gaagcacgag gacaaacgtg gaggtagcgg atctcacaac tggggaactg tcaaagacga   1140

attaactgac ttggatcaat caaatgtgac tgaggaaaca cctgaaggtg aagaacatca   1200

tccagtggca gacactgaaa ataaggagaa tgaagttgaa gaggtaaaag aggagggtcc   1260

aaaagagatg actttggatg agtggaaggc tattcaaaat aaggaccggg caaaagtaga   1320

atttaatatc cgaaaaccaa atgaaggtgc tgatgggcag tggaagaagg gatttgttct   1380

tcataaatca aagagtgaag aggctcatgc tgaagattcg gttatggacc atcatttccg   1440

gaagccagca aatgatataa cgtctcagct ggagatcaat tttggagacc ttggccgccc   1500

aggacgtggc ggcaggggag gacgaggtgg acgtgggcgt ggtgggcgcc caaaccgtgg   1560

cagcaggacc gacaagtcaa gtgcttctgc tcctgatgtg gatgacccag aggcattccc   1620

agctctggct taactggatg ccataagaca accctggttc ctttgtgaac ccttctgttc   1680

aaagcttttg catgcttaag gattccaaac gactaagaaa tt                      1722


<210>  643
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  643


Met Thr Leu Ala Tyr Ile Pro His Ser Ala Leu Arg Arg Arg Pro Leu 
1               5                   10                  15      


Pro Asp Val Cys Leu Ala Pro Glu Glu Lys Thr Ala Pro Leu Ser Arg 
            20                  25                  30          


Pro Gly His Leu Val Gly Arg Ala Glu Ala Gly Ala Leu Gly Ser Ala 
        35                  40                  45              


Arg Pro Ala Ala Ile Arg Gly Gly Thr Arg Arg Arg Ala Thr Ile Met 
    50                  55                  60                  


Pro Gly His Leu Gln Glu Gly Phe Gly Cys Val Val Thr Asn Arg Phe 
65                  70                  75                  80  


Asp Gln Leu Phe Asp Asp Glu Ser Asp Pro Phe Glu Val Leu Lys Ala 
                85                  90                  95      


Ala Glu Asn Lys Lys Lys Glu Ala Gly Gly Gly Gly Val Gly Gly Pro 
            100                 105                 110         


Gly Ala Lys Ser Ala Ala Gln Ala Ala Ala Gln Thr Asn Ser Asn Ala 
        115                 120                 125             


Ala Gly Lys Gln Leu Arg Lys Glu Ser Gln Lys Asp Arg Lys Asn Pro 
    130                 135                 140                 


Leu Pro Pro Ser Val Gly Val Val Asp Lys Lys Glu Glu Thr Gln Pro 
145                 150                 155                 160 


Pro Val Ala Leu Lys Lys Glu Gly Ile Arg Arg Val Gly Arg Arg Pro 
                165                 170                 175     


Asp Gln Gln Leu Gln Gly Glu Gly Lys Ile Ile Asp Arg Arg Pro Glu 
            180                 185                 190         


Arg Arg Pro Pro Arg Glu Arg Arg Phe Glu Lys Pro Leu Glu Glu Lys 
        195                 200                 205             


Gly Glu Gly Gly Glu Phe Ser Val Asp Arg Pro Ile Ile Asp Arg Pro 
    210                 215                 220                 


Ile Arg Gly Arg Gly Gly Leu Gly Arg Gly Arg Gly Gly Arg Gly Arg 
225                 230                 235                 240 


Gly Met Gly Arg Gly Asp Gly Phe Asp Ser Arg Gly Lys Arg Glu Phe 
                245                 250                 255     


Asp Arg His Ser Gly Ser Asp Arg Ser Gly Leu Lys His Glu Asp Lys 
            260                 265                 270         


Arg Gly Gly Ser Gly Ser His Asn Trp Gly Thr Val Lys Asp Glu Leu 
        275                 280                 285             


Thr Asp Leu Asp Gln Ser Asn Val Thr Glu Glu Thr Pro Glu Gly Glu 
    290                 295                 300                 


Glu His His Pro Val Ala Asp Thr Glu Asn Lys Glu Asn Glu Val Glu 
305                 310                 315                 320 


Glu Val Lys Glu Glu Gly Pro Lys Glu Met Thr Leu Asp Glu Trp Lys 
                325                 330                 335     


Ala Ile Gln Asn Lys Asp Arg Ala Lys Val Glu Phe Asn Ile Arg Lys 
            340                 345                 350         


Pro Asn Glu Gly Ala Asp Gly Gln Trp Lys Lys Gly Phe Val Leu His 
        355                 360                 365             


Lys Ser Lys Ser Glu Glu Ala His Ala Glu Asp Ser Val Met Asp His 
    370                 375                 380                 


His Phe Arg Lys Pro Ala Asn Asp Ile Thr Ser Gln Leu Glu Ile Asn 
385                 390                 395                 400 


Phe Gly Asp Leu Gly Arg Pro Gly Arg Gly Gly Arg Gly Gly Arg Gly 
                405                 410                 415     


Gly Arg Gly Arg Gly Gly Arg Pro Asn Arg Gly Ser Arg Thr Asp Lys 
            420                 425                 430         


Ser Ser Ala Ser Ala Pro Asp Val Asp Asp Pro Glu Ala Phe Pro Ala 
        435                 440                 445             


Leu Ala 
    450 

<210>  644
<211>  1767
<212>  DNA
<213>  Homo sapiens

<400>  644
gttagccctg agcccgaggg ggcgtgagtg aaaccaaaga gcactttcgc gagtcagtta     60

cgccgtcacg gttttttggt ttcaaggtag ctgaagacct agagagttta agggtggcca    120

gagcaggtgg caggactccg cccaccacca cgcttccctt ccttcagccc gcacgcttca    180

ctcccctcat ggggtctcgc ctctcaggcg cgcgcgaaga gttgtcgcgc ggtgcgtcct    240

gggaattgta gtcccgacgc ggagagtcgc ctcaggagaa atgactctgg cctacatacc    300

ccacagtgcc ttgcggcgca ggccgctccc ggatgtgtgc ctggcgccgg aagagaagac    360

ggcccccctc tctcggcccg gccatcttgt gggaagagct gaagcaggcg ctcttggctc    420

ggcgcggccc gctgcaatcc gtggaggaac gcgccgccga gccaccatca tgcctgggca    480

cttacaggaa ggcttcggct gcgtggtcac caaccgattc gaccagttat ttgacgacga    540

atcggacccc ttcgaggtgc tgaaggcagc agagaacaag aaaaaagaag ccggcggggg    600

cggcgttggg ggccctgggg ccaagagcgc agctcaggcc gcggcccaga ccaactccaa    660

cgcggcaggc aaacagctgc gcaaggagtc ccagaaagac cgcaagaacc cgctgccccc    720

cagcgttggc gtggttgaca agaaagagga gacgcagccg cccgtggcgc ttaagaaaga    780

aggaataaga cgagttggaa gaagacctga tcaacaactt cagggtgaag ggaaaataat    840

tgatagaaga ccagaaaggc gaccacctcg tgaacgaaga ttcgaaaagc cacttgaaga    900

aaagggtgaa ggaggcgaat tttcagttga tagaccgatt attgaccgac ctattcgagg    960

tcgtggtggt cttggaagag gtcgaggggg ccgtggacgt ggaatgggcc gaggagatgg   1020

atttgattct cgtggcaaac gtgaatttga taggcatagt ggaagtgata gatctggcct   1080

gaagcacgag gacaaacgtg gaggtagcgg atctcacaac tggggaactg tcaaagacga   1140

attaacagag tcccccaaat acattcagaa acaaatatct tataattaca gtgacttgga   1200

tcaatcaaat gtgactgagg aaacacctga aggtgaagaa catcatccag tggcagacac   1260

tgaaaataag gagaatgaag ttgaagaggt aaaagaggag ggtccaaaag agatgacttt   1320

ggatgagtgg aaggctattc aaaataagga ccgggcaaaa gtagaattta atatccgaaa   1380

accaaatgaa ggtgctgatg ggcagtggaa gaagggattt gttcttcata aatcaaagag   1440

tgaagaggct catgctgaag attcggttat ggaccatcat ttccggaagc cagcaaatga   1500

tataacgtct cagctggaga tcaattttgg agaccttggc cgcccaggac gtggcggcag   1560

gggaggacga ggtggacgtg ggcgtggtgg gcgcccaaac cgtggcagca ggaccgacaa   1620

gtcaagtgct tctgctcctg atgtggatga cccagaggca ttcccagctc tggcttaact   1680

ggatgccata agacaaccct ggttcctttg tgaacccttc tgttcaaagc ttttgcatgc   1740

ttaaggattc caaacgacta agaaatt                                       1767


<210>  645
<211>  465
<212>  PRT
<213>  Homo sapiens

<400>  645


Met Thr Leu Ala Tyr Ile Pro His Ser Ala Leu Arg Arg Arg Pro Leu 
1               5                   10                  15      


Pro Asp Val Cys Leu Ala Pro Glu Glu Lys Thr Ala Pro Leu Ser Arg 
            20                  25                  30          


Pro Gly His Leu Val Gly Arg Ala Glu Ala Gly Ala Leu Gly Ser Ala 
        35                  40                  45              


Arg Pro Ala Ala Ile Arg Gly Gly Thr Arg Arg Arg Ala Thr Ile Met 
    50                  55                  60                  


Pro Gly His Leu Gln Glu Gly Phe Gly Cys Val Val Thr Asn Arg Phe 
65                  70                  75                  80  


Asp Gln Leu Phe Asp Asp Glu Ser Asp Pro Phe Glu Val Leu Lys Ala 
                85                  90                  95      


Ala Glu Asn Lys Lys Lys Glu Ala Gly Gly Gly Gly Val Gly Gly Pro 
            100                 105                 110         


Gly Ala Lys Ser Ala Ala Gln Ala Ala Ala Gln Thr Asn Ser Asn Ala 
        115                 120                 125             


Ala Gly Lys Gln Leu Arg Lys Glu Ser Gln Lys Asp Arg Lys Asn Pro 
    130                 135                 140                 


Leu Pro Pro Ser Val Gly Val Val Asp Lys Lys Glu Glu Thr Gln Pro 
145                 150                 155                 160 


Pro Val Ala Leu Lys Lys Glu Gly Ile Arg Arg Val Gly Arg Arg Pro 
                165                 170                 175     


Asp Gln Gln Leu Gln Gly Glu Gly Lys Ile Ile Asp Arg Arg Pro Glu 
            180                 185                 190         


Arg Arg Pro Pro Arg Glu Arg Arg Phe Glu Lys Pro Leu Glu Glu Lys 
        195                 200                 205             


Gly Glu Gly Gly Glu Phe Ser Val Asp Arg Pro Ile Ile Asp Arg Pro 
    210                 215                 220                 


Ile Arg Gly Arg Gly Gly Leu Gly Arg Gly Arg Gly Gly Arg Gly Arg 
225                 230                 235                 240 


Gly Met Gly Arg Gly Asp Gly Phe Asp Ser Arg Gly Lys Arg Glu Phe 
                245                 250                 255     


Asp Arg His Ser Gly Ser Asp Arg Ser Gly Leu Lys His Glu Asp Lys 
            260                 265                 270         


Arg Gly Gly Ser Gly Ser His Asn Trp Gly Thr Val Lys Asp Glu Leu 
        275                 280                 285             


Thr Glu Ser Pro Lys Tyr Ile Gln Lys Gln Ile Ser Tyr Asn Tyr Ser 
    290                 295                 300                 


Asp Leu Asp Gln Ser Asn Val Thr Glu Glu Thr Pro Glu Gly Glu Glu 
305                 310                 315                 320 


His His Pro Val Ala Asp Thr Glu Asn Lys Glu Asn Glu Val Glu Glu 
                325                 330                 335     


Val Lys Glu Glu Gly Pro Lys Glu Met Thr Leu Asp Glu Trp Lys Ala 
            340                 345                 350         


Ile Gln Asn Lys Asp Arg Ala Lys Val Glu Phe Asn Ile Arg Lys Pro 
        355                 360                 365             


Asn Glu Gly Ala Asp Gly Gln Trp Lys Lys Gly Phe Val Leu His Lys 
    370                 375                 380                 


Ser Lys Ser Glu Glu Ala His Ala Glu Asp Ser Val Met Asp His His 
385                 390                 395                 400 


Phe Arg Lys Pro Ala Asn Asp Ile Thr Ser Gln Leu Glu Ile Asn Phe 
                405                 410                 415     


Gly Asp Leu Gly Arg Pro Gly Arg Gly Gly Arg Gly Gly Arg Gly Gly 
            420                 425                 430         


Arg Gly Arg Gly Gly Arg Pro Asn Arg Gly Ser Arg Thr Asp Lys Ser 
        435                 440                 445             


Ser Ala Ser Ala Pro Asp Val Asp Asp Pro Glu Ala Phe Pro Ala Leu 
    450                 455                 460                 


Ala 
465 

<210>  646
<211>  1089
<212>  DNA
<213>  Homo sapiens

<400>  646
gttagccctg agcccgaggg ggcgtgagtg aaaccaaaga gcactttcgc gagtcagtta     60

cgccgtcacg gttttttggt ttcaaggtag ctgaagacct agagagttta agggtggcca    120

gagcaggtgg caggactccg cccaccacca cgcttccctt ccttcagccc gcacgcttca    180

ctcccctcat ggggtctcgc ctctcaggcg cgcgcgaaga gttgtcgcgc ggtgcgtcct    240

gggaattgta gtcccgacgc ggagagtcgc ctcaggagaa atgactctgg cctacatacc    300

ccacagtgcc ttgcggcgca ggccgctccc ggatgtgtgc ctggcgccgg aagagaagac    360

ggcccccctc tctcggcccg gccatcttgt gggaagagct gaagcaggcg ctcttggctc    420

ggcgcggccc gctgcaatcc gtggaggaac gcgccgccga gccaccatca tgcctgggca    480

cttacaggaa ggcttcggct gcgtggtcac caaccgattc gaccagttat ttgacgacga    540

atcggacccc ttcgaggtgc tgaaggcagc agagaacaag aaaaaagaag ccggcggggg    600

cggcgttggg ggccctgggg ccaagagcgc agctcaggcc gcggcccaga ccaactccaa    660

cgcggcaggc aaacagctgc gcaaggagtc ccagaaagac cgcaagaacc cgctgccccc    720

cagcgttggc gtggttgaca agaaagagga gacgcagccg cccgtggcgc ttaagaaaga    780

aggaataaga cgagttggaa gaagacctga tcaacaactt cagggtgaag ggaaaataat    840

tgatagaaga ccagaaaggc gaccacctcg tgaacgaaga ttcgaaaagc cacttgaaga    900

aaagggtgaa ggaggcgaat tttcagttga tagaccgatt attgaccgac ctattcgagg    960

tcgtggtggt cttggaagag gtcgaggggg ccgtggacgt ggaatgggcc gaggagatgg   1020

atttgattct cgtggcaaac gtgaatttga taggcatagt ggaagtgata gatcttcttt   1080

ttcacatta                                                           1089


<210>  647
<211>  268
<212>  PRT
<213>  Homo sapiens

<400>  647


Met Thr Leu Ala Tyr Ile Pro His Ser Ala Leu Arg Arg Arg Pro Leu 
1               5                   10                  15      


Pro Asp Val Cys Leu Ala Pro Glu Glu Lys Thr Ala Pro Leu Ser Arg 
            20                  25                  30          


Pro Gly His Leu Val Gly Arg Ala Glu Ala Gly Ala Leu Gly Ser Ala 
        35                  40                  45              


Arg Pro Ala Ala Ile Arg Gly Gly Thr Arg Arg Arg Ala Thr Ile Met 
    50                  55                  60                  


Pro Gly His Leu Gln Glu Gly Phe Gly Cys Val Val Thr Asn Arg Phe 
65                  70                  75                  80  


Asp Gln Leu Phe Asp Asp Glu Ser Asp Pro Phe Glu Val Leu Lys Ala 
                85                  90                  95      


Ala Glu Asn Lys Lys Lys Glu Ala Gly Gly Gly Gly Val Gly Gly Pro 
            100                 105                 110         


Gly Ala Lys Ser Ala Ala Gln Ala Ala Ala Gln Thr Asn Ser Asn Ala 
        115                 120                 125             


Ala Gly Lys Gln Leu Arg Lys Glu Ser Gln Lys Asp Arg Lys Asn Pro 
    130                 135                 140                 


Leu Pro Pro Ser Val Gly Val Val Asp Lys Lys Glu Glu Thr Gln Pro 
145                 150                 155                 160 


Pro Val Ala Leu Lys Lys Glu Gly Ile Arg Arg Val Gly Arg Arg Pro 
                165                 170                 175     


Asp Gln Gln Leu Gln Gly Glu Gly Lys Ile Ile Asp Arg Arg Pro Glu 
            180                 185                 190         


Arg Arg Pro Pro Arg Glu Arg Arg Phe Glu Lys Pro Leu Glu Glu Lys 
        195                 200                 205             


Gly Glu Gly Gly Glu Phe Ser Val Asp Arg Pro Ile Ile Asp Arg Pro 
    210                 215                 220                 


Ile Arg Gly Arg Gly Gly Leu Gly Arg Gly Arg Gly Gly Arg Gly Arg 
225                 230                 235                 240 


Gly Met Gly Arg Gly Asp Gly Phe Asp Ser Arg Gly Lys Arg Glu Phe 
                245                 250                 255     


Asp Arg His Ser Gly Ser Asp Arg Ser Ser Phe Ser 
            260                 265             

<210>  648
<211>  1577
<212>  DNA
<213>  Homo sapiens

<400>  648
tcccttcttc ctgaggacag actgaagaaa catccaaggt ggtcttgaag gacactggga     60

tcctgtaaca cagccccgga tatctgtgtt accagccttg tctcggccac ctcaaggata    120

atcactaaat tctgccgaaa ggactgagga acggtgcctg gaaaagggca agaatatcac    180

ggcatgggca tgagtagctt gaaactgctg aagtatgtcc tgtttttctt caacttgctc    240

ttttggatct gtggctgctg cattttgggc tttgggatct acctgctgat ccacaacaac    300

ttcggagtgc tcttccataa cctcccctcc ctcacgctgg gcaatgtgtt tgtcatcgtg    360

ggctctatta tcatggtagt tgccttcctg ggctgcatgg gctctatcaa ggaaaacaag    420

tgtctgctta tgtcgttctt catcctgctg ctgattatcc tccttgctga ggtgaccttg    480

gccatcctgc tctttgtata tgaacagaag ctgaatgagt atgtggctaa gggtctgacc    540

gacagcatcc accgttacca ctcagacaat agcaccaagg cagcgtggga ctccatccag    600

tcatttctgc agtgttgtgg tataaatggc acgagtgatt ggaccagtgg cccaccagca    660

tcttgcccct cagatcgaaa agtggagggt tgctatgcga aagcaagact gtggtttcat    720

tccaatttcc tgtatatcgg aatcatcacc atctgtgtat gtgtgattga ggtgttgggg    780

atgtcctttg cactgaccct gaactgccag attgacaaaa ccagccagac catagggcta    840

tgatctgcag tagtcctgtg gtgaagagac ttgtttcatc tccggaaatg caaaaccatt    900

tatagcatga agccctacat gatcactgca ggatgatcct cctcccatcc tttccctttt    960

taggtccctg tcttatacaa ccagagaagt gggtgttggc caggcacatc ccatctcagg   1020

cagcaagaca atctttcact cactgacggc agcagccatg tctctcaaag tggtgaaact   1080

aatatctgag catcttttag acaagagagg caaagacaaa ctggatttaa tggcccaaca   1140

tcaaagggtg aacccaggat atgaattttt gcatcttccc attgtcgaat tagtctccag   1200

cctctaaata atgcccagtc ttctccccaa agtcaagcaa gagactagtt gaagggagtt   1260

ctggggccag gctcactgga ccattgtcac aaccctctgt ttctctttga ctaagtgccc   1320

tggctacagg aattacacag ttctctttct ccaaagggca agatctcatt tcaatttctt   1380

tattagaggg ccttattgat gtgttctaag tctttccaga aaaaaactat ccagtgattt   1440

atatcctgat ttcaaccagt cacttagctg ataatcacag taagaagact tctggtatta   1500

tctctctatc agataagatt ttgttaatgt actattttac tcttcaataa ataaaagttt   1560

attatctcaa tcacaac                                                  1577


<210>  649
<211>  219
<212>  PRT
<213>  Homo sapiens

<400>  649


Met Gly Met Ser Ser Leu Lys Leu Leu Lys Tyr Val Leu Phe Phe Phe 
1               5                   10                  15      


Asn Leu Leu Phe Trp Ile Cys Gly Cys Cys Ile Leu Gly Phe Gly Ile 
            20                  25                  30          


Tyr Leu Leu Ile His Asn Asn Phe Gly Val Leu Phe His Asn Leu Pro 
        35                  40                  45              


Ser Leu Thr Leu Gly Asn Val Phe Val Ile Val Gly Ser Ile Ile Met 
    50                  55                  60                  


Val Val Ala Phe Leu Gly Cys Met Gly Ser Ile Lys Glu Asn Lys Cys 
65                  70                  75                  80  


Leu Leu Met Ser Phe Phe Ile Leu Leu Leu Ile Ile Leu Leu Ala Glu 
                85                  90                  95      


Val Thr Leu Ala Ile Leu Leu Phe Val Tyr Glu Gln Lys Leu Asn Glu 
            100                 105                 110         


Tyr Val Ala Lys Gly Leu Thr Asp Ser Ile His Arg Tyr His Ser Asp 
        115                 120                 125             


Asn Ser Thr Lys Ala Ala Trp Asp Ser Ile Gln Ser Phe Leu Gln Cys 
    130                 135                 140                 


Cys Gly Ile Asn Gly Thr Ser Asp Trp Thr Ser Gly Pro Pro Ala Ser 
145                 150                 155                 160 


Cys Pro Ser Asp Arg Lys Val Glu Gly Cys Tyr Ala Lys Ala Arg Leu 
                165                 170                 175     


Trp Phe His Ser Asn Phe Leu Tyr Ile Gly Ile Ile Thr Ile Cys Val 
            180                 185                 190         


Cys Val Ile Glu Val Leu Gly Met Ser Phe Ala Leu Thr Leu Asn Cys 
        195                 200                 205             


Gln Ile Asp Lys Thr Ser Gln Thr Ile Gly Leu 
    210                 215                 

<210>  650
<211>  1909
<212>  DNA
<213>  Homo sapiens

<400>  650
tcccttcttc ctgaggacag actgaagaaa catccaaggt ggtcttgaag gacactggga     60

tcctgtaaca cagccccgga tatctgtgtt accagccttg tctcggccac ctcaaggata    120

atcactaaat tctgccgaaa ggactgagga acggtgcctg gaaaagggca agaatatcac    180

ggcatgggca tgagtagctt gaaactgctg aagtatgtcc tgtttttctt caacttgctc    240

ttttggatct gtggctgctg cattttgggc tttgggatct acctgctgat ccacaacaac    300

ttcggagtgc tcttccataa cctcccctcc ctcacgctgg gcaatgtgtt tgtcatcgtg    360

ggctctatta tcatggtagt tgccttcctg ggctgcatgg gctctatcaa ggaaaacaag    420

tgtctgctta tgtcgttctt catcctgctg ctgattatcc tccttgctga ggtgaccttg    480

gccatcctgc tctttgtata tgaacagaag ctgaatgagt atgtggctaa gggtctgacc    540

gacagcatcc accgttacca ctcagacaat agcaccaagg cagcgtggga ctccatccag    600

tcatttctgc agtgttgtgg tataaatggc acgagtgatt ggaccagtgg cccaccagca    660

tcttgcccct cagatcgaaa agtggagggt tgctatgcga aagcaagact gtggtttcat    720

tccaatttcc tgtatatcgg aatcatcacc atctgtgtat gtgtgattga ggtgttgggg    780

atgtcctttg cactgaccct gaactgccag attgacaaaa ccagccagac catagggcta    840

tgatctgcag tagtcctgtg gtgaagagac ttgtttcatc tccggaaatg caaaaccatt    900

tatagcatga agccctacat gatcactgca ggatgatcct cctcccatcc tttccctttt    960

taggtccctg tcttatacaa ccagagaagt gggtgttggc caggcacatc ccatctcagg   1020

cagcaagaca atctttcact cactgacggc agcagccatg tctctcaaag tggtgaaact   1080

aatatctgag catcttttag acaagagagg caaagacaaa ctggatttaa tggcccaaca   1140

tcaaagggtg aacccaggat atgaattttt gcatcttccc attgtcgaat tagtctccag   1200

cctctaaata atgcccagtc ttctccccaa agtcaagcaa gagactagtt gaagggagtt   1260

ctggggccag gctcactgga ccattgtcac aaccctctgt ttctctttga ctaagtgccc   1320

tggctacagg aattacacag ttctctttct ccaaagggca agatctcatt tcaatttctt   1380

tattagaggg ccttattgat gtgttctaag tctttccaga aaaaaactat ccagtgattt   1440

atatcctgat ttcaaccagt cacttagctg ataatcacag taagaagact tctggtatta   1500

tctctctatc agataagatt ttgttaatgt actattttac tcttcaataa ataaaagttt   1560

attatctcaa tcacaacatt gctatatatc aaacactcct tccatgaccc agcctgatta   1620

ccctgattaa tgcaccaaac caggtgtatt aattgtctcc tgctgcataa aatattactc   1680

caaaatttag tggctgagga caacaaacat ttattatctc atggtttttg tgggtcagga   1740

atctaggagc agcttagctg ggtgattctg gttcacagtc tctcatgtaa ctgcaatcaa   1800

catgtcagcc tgggctgcag taaccttaag gctcaactga aagaggatct actttcaggc   1860

tctctcacat cgctgttggc aagcctcaga tctttgccac ttgtgcctt               1909


<210>  651
<211>  219
<212>  PRT
<213>  Homo sapiens

<400>  651


Met Gly Met Ser Ser Leu Lys Leu Leu Lys Tyr Val Leu Phe Phe Phe 
1               5                   10                  15      


Asn Leu Leu Phe Trp Ile Cys Gly Cys Cys Ile Leu Gly Phe Gly Ile 
            20                  25                  30          


Tyr Leu Leu Ile His Asn Asn Phe Gly Val Leu Phe His Asn Leu Pro 
        35                  40                  45              


Ser Leu Thr Leu Gly Asn Val Phe Val Ile Val Gly Ser Ile Ile Met 
    50                  55                  60                  


Val Val Ala Phe Leu Gly Cys Met Gly Ser Ile Lys Glu Asn Lys Cys 
65                  70                  75                  80  


Leu Leu Met Ser Phe Phe Ile Leu Leu Leu Ile Ile Leu Leu Ala Glu 
                85                  90                  95      


Val Thr Leu Ala Ile Leu Leu Phe Val Tyr Glu Gln Lys Leu Asn Glu 
            100                 105                 110         


Tyr Val Ala Lys Gly Leu Thr Asp Ser Ile His Arg Tyr His Ser Asp 
        115                 120                 125             


Asn Ser Thr Lys Ala Ala Trp Asp Ser Ile Gln Ser Phe Leu Gln Cys 
    130                 135                 140                 


Cys Gly Ile Asn Gly Thr Ser Asp Trp Thr Ser Gly Pro Pro Ala Ser 
145                 150                 155                 160 


Cys Pro Ser Asp Arg Lys Val Glu Gly Cys Tyr Ala Lys Ala Arg Leu 
                165                 170                 175     


Trp Phe His Ser Asn Phe Leu Tyr Ile Gly Ile Ile Thr Ile Cys Val 
            180                 185                 190         


Cys Val Ile Glu Val Leu Gly Met Ser Phe Ala Leu Thr Leu Asn Cys 
        195                 200                 205             


Gln Ile Asp Lys Thr Ser Gln Thr Ile Gly Leu 
    210                 215                 

<210>  652
<211>  1216
<212>  DNA
<213>  Homo sapiens

<400>  652
agaaacatcc aaggtggtct tgaaggacac tgggatcctg taacacagcc ccggatatct     60

gtgttaccag ccttgtctcg gccacctcaa ggataatcac taaattctgc cgaaaggact    120

gaggaacggt gcctggaaaa gggcaagaat atcacggcat gggcatgagt agcttgaaac    180

tgctgaagta tgtcctgttt ttcttcaact tgctcttttg gatctgtggc tgctgcattt    240

tgggctttgg gatctacctg ctgatccaca acaacttcgg agtgctcttc cataacctcc    300

cctccctcac gctgggcaat gtgtttgtca tcgtgggctc tattatcatg gtagttgcct    360

tcctgggctg catgggctct atcaaggaaa acaagtgtct gcttatgtcg gtgttgggga    420

tgtcctttgc actgaccctg aactgccaga ttgacaaaac cagccagacc atagggctat    480

gatctgcagt agtcctgtgg tgaagagact tgtttcatct ccggaaatgc aaaaccattt    540

atagcatgaa gccctacatg atcactgcag gatgatcctc ctcccatcct ttcccttttt    600

aggtccctgt cttatacaac cagagaagtg ggtgttggcc aggcacatcc catctcaggc    660

agcaagacaa tctttcactc actgacggca gcagccatgt ctctcaaagt ggtgaaacta    720

atatctgagc atcttttaga caagagaggc aaagacaaac tggatttaat ggcccaacat    780

caaagggtga acccaggata tgaatttttg catcttccca ttgtcgaatt agtctccagc    840

ctctaaataa tgcccagtct tctccccaaa gtcaagcaag agactagttg aagggagttc    900

tggggccagg ctcactggac cattgtcaca accctctgtt tctctttgac taagtgccct    960

ggctacagga attacacagt tctctttctc caaagggcaa gatctcattt caatttcttt   1020

attagagggc cttattgatg tgttctaagt ctttccagaa aaaaactatc cagtgattta   1080

tatcctgatt tcaaccagtc acttagctga taatcacagt aagaagactt ctggtattat   1140

ctctctatca gataagattt tgttaatgta ctattttact cttcaataaa taaaagttta   1200

ttatctcaat cacaac                                                   1216


<210>  653
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  653


Met Gly Met Ser Ser Leu Lys Leu Leu Lys Tyr Val Leu Phe Phe Phe 
1               5                   10                  15      


Asn Leu Leu Phe Trp Ile Cys Gly Cys Cys Ile Leu Gly Phe Gly Ile 
            20                  25                  30          


Tyr Leu Leu Ile His Asn Asn Phe Gly Val Leu Phe His Asn Leu Pro 
        35                  40                  45              


Ser Leu Thr Leu Gly Asn Val Phe Val Ile Val Gly Ser Ile Ile Met 
    50                  55                  60                  


Val Val Ala Phe Leu Gly Cys Met Gly Ser Ile Lys Glu Asn Lys Cys 
65                  70                  75                  80  


Leu Leu Met Ser Val Leu Gly Met Ser Phe Ala Leu Thr Leu Asn Cys 
                85                  90                  95      


Gln Ile Asp Lys Thr Ser Gln Thr Ile Gly Leu 
            100                 105         

<210>  654
<211>  1548
<212>  DNA
<213>  Homo sapiens

<400>  654
agaaacatcc aaggtggtct tgaaggacac tgggatcctg taacacagcc ccggatatct     60

gtgttaccag ccttgtctcg gccacctcaa ggataatcac taaattctgc cgaaaggact    120

gaggaacggt gcctggaaaa gggcaagaat atcacggcat gggcatgagt agcttgaaac    180

tgctgaagta tgtcctgttt ttcttcaact tgctcttttg gatctgtggc tgctgcattt    240

tgggctttgg gatctacctg ctgatccaca acaacttcgg agtgctcttc cataacctcc    300

cctccctcac gctgggcaat gtgtttgtca tcgtgggctc tattatcatg gtagttgcct    360

tcctgggctg catgggctct atcaaggaaa acaagtgtct gcttatgtcg gtgttgggga    420

tgtcctttgc actgaccctg aactgccaga ttgacaaaac cagccagacc atagggctat    480

gatctgcagt agtcctgtgg tgaagagact tgtttcatct ccggaaatgc aaaaccattt    540

atagcatgaa gccctacatg atcactgcag gatgatcctc ctcccatcct ttcccttttt    600

aggtccctgt cttatacaac cagagaagtg ggtgttggcc aggcacatcc catctcaggc    660

agcaagacaa tctttcactc actgacggca gcagccatgt ctctcaaagt ggtgaaacta    720

atatctgagc atcttttaga caagagaggc aaagacaaac tggatttaat ggcccaacat    780

caaagggtga acccaggata tgaatttttg catcttccca ttgtcgaatt agtctccagc    840

ctctaaataa tgcccagtct tctccccaaa gtcaagcaag agactagttg aagggagttc    900

tggggccagg ctcactggac cattgtcaca accctctgtt tctctttgac taagtgccct    960

ggctacagga attacacagt tctctttctc caaagggcaa gatctcattt caatttcttt   1020

attagagggc cttattgatg tgttctaagt ctttccagaa aaaaactatc cagtgattta   1080

tatcctgatt tcaaccagtc acttagctga taatcacagt aagaagactt ctggtattat   1140

ctctctatca gataagattt tgttaatgta ctattttact cttcaataaa taaaagttta   1200

ttatctcaat cacaacattg ctatatatca aacactcctt ccatgaccca gcctgattac   1260

cctgattaat gcaccaaacc aggtgtatta attgtctcct gctgcataaa atattactcc   1320

aaaatttagt ggctgaggac aacaaacatt tattatctca tggtttttgt gggtcaggaa   1380

tctaggagca gcttagctgg gtgattctgg ttcacagtct ctcatgtaac tgcaatcaac   1440

atgtcagcct gggctgcagt aaccttaagg ctcaactgaa agaggatcta ctttcaggct   1500

ctctcacatc gctgttggca agcctcagat ctttgccact tgtgcctt                1548


<210>  655
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  655


Met Gly Met Ser Ser Leu Lys Leu Leu Lys Tyr Val Leu Phe Phe Phe 
1               5                   10                  15      


Asn Leu Leu Phe Trp Ile Cys Gly Cys Cys Ile Leu Gly Phe Gly Ile 
            20                  25                  30          


Tyr Leu Leu Ile His Asn Asn Phe Gly Val Leu Phe His Asn Leu Pro 
        35                  40                  45              


Ser Leu Thr Leu Gly Asn Val Phe Val Ile Val Gly Ser Ile Ile Met 
    50                  55                  60                  


Val Val Ala Phe Leu Gly Cys Met Gly Ser Ile Lys Glu Asn Lys Cys 
65                  70                  75                  80  


Leu Leu Met Ser Val Leu Gly Met Ser Phe Ala Leu Thr Leu Asn Cys 
                85                  90                  95      


Gln Ile Asp Lys Thr Ser Gln Thr Ile Gly Leu 
            100                 105         

<210>  656
<211>  1434
<212>  DNA
<213>  Homo sapiens

<400>  656
atttctacca gtgcccctgg gattatgcct tggggactca ccttaagaca gtcttgctct     60

cgagacagag aagtctgcaa atggtgtcca attcaagtct agagactggc tgaagccaga    120

cagagggagt atgaggaggg ggcagagaat cttcagaaag acattccaaa gtctcgggcc    180

tagaaaatgt ttagaaatat tggttcctgt gttcccctcc agtctgtcta cctgaatggg    240

aaactggtgg tggggccagg catacttctt tttgaacaaa tacacagtta attctgagat    300

gccaccttga ttgagaagca ctgtcctttt ctaagcaaaa atcattgcca aattacccta    360

gaatccacca ctgctcacag atctgtgcct gaaccaactt ggttttgaag ttttcttttg    420

tttcacaaaa ctagtttagg gtgggctgtg agaggaagct tctaaaaagc cactgggaaa    480

gtactaaatc tctgagacta aagagggcgg actcagcctc acttcctcct tcttctcatc    540

tgggcttcct gtcgtcacag catgatcata ttttttcacc cttcacttct ccttttacac    600

aaatagcccc ggatatctgt gttaccagcc ttgtctcggc cacctcaagg ataatcacta    660

aattctgccg aaaggactga ggaacggtgc ctggaaaagg gcaagaatat cacggcatgg    720

gcatgagtag cttgaaactg ctgaagtatg tcctgttttt cttcaacttg ctcttttgga    780

tctgtggctg ctgcattttg ggctttggga tctacctgct gatccacaac aacttcggag    840

tgctcttcca taacctcccc tccctcacgc tgggcaatgt gtttgtcatc gtgggctcta    900

ttatcatggt agttgccttc ctgggctgca tgggctctat caaggaaaac aagtgtctgc    960

ttatgtcgtt cttcatcctg ctgctgatta tcctccttgc tgaggtgacc ttggccatcc   1020

tgctctttgt atatgaacag aaggtaagtt ataaagacaa caacttattg tcttaatact   1080

gaaagtgggg agtatgcagt ggagaagttg gtacaaagtt acagaataag ttctataata   1140

gagatagaaa tgaagtggaa ggatagagga aacagagagt aattgtaatt ggggggaaaa   1200

tttgtatgaa agagattgta tctgagtggt atcttgaggg gtgcctggaa agagcagtaa   1260

aacaagtgtc tcttcctcta cttgctttcc tctgtgtgtt tggcaggaga gaatgtctgc   1320

ctcagtgcct aaggatagcc cttgctttaa ttgctccttt tcctcccttg taaagccaga   1380

gctctagaag gaagcaagcc tactaaatac ttcttccttc aatgccacct catg         1434


<210>  657
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  657


Met Gly Met Ser Ser Leu Lys Leu Leu Lys Tyr Val Leu Phe Phe Phe 
1               5                   10                  15      


Asn Leu Leu Phe Trp Ile Cys Gly Cys Cys Ile Leu Gly Phe Gly Ile 
            20                  25                  30          


Tyr Leu Leu Ile His Asn Asn Phe Gly Val Leu Phe His Asn Leu Pro 
        35                  40                  45              


Ser Leu Thr Leu Gly Asn Val Phe Val Ile Val Gly Ser Ile Ile Met 
    50                  55                  60                  


Val Val Ala Phe Leu Gly Cys Met Gly Ser Ile Lys Glu Asn Lys Cys 
65                  70                  75                  80  


Leu Leu Met Ser Phe Phe Ile Leu Leu Leu Ile Ile Leu Leu Ala Glu 
                85                  90                  95      


Val Thr Leu Ala Ile Leu Leu Phe Val Tyr Glu Gln Lys Val Ser Tyr 
            100                 105                 110         


Lys Asp Asn Asn Leu Leu Ser 
        115                 

<210>  658
<211>  1303
<212>  DNA
<213>  Homo sapiens

<400>  658
agtcttgctc tcgagacaga gaagtctgca aatggtgtcc aattcaagtc tagagactgg     60

ctgaagccag acagagggag tatgaggagg gggcagagaa tcttcagaaa gacattccaa    120

agtctcgggc ctagaaaatg tttagaaata ttggttcctg tgttcccctc cagtctgtct    180

acctgaatgg gaaactggtg gtggggccag gcatacttct ttttgaacaa atacacagtt    240

aattctgaga tgccaccttg attgagaagc actgtccttt tctaagcaaa aatcattgcc    300

aaattaccct agaatccacc actgctcaca gatctgtgcc tgaaccaact tggttttgaa    360

gttttctttt gtttcacaaa actagtttag ggtgggctgt gagaggaagc ttctaaaaag    420

ccactgggaa agtactaaat ctctgagact aaagagggcg gactcagcct cacttcctcc    480

ttcttctcat ctgggcttcc tgtcgtcaca gcatgatcat attttttcac ccttcacttc    540

tccttttaca caaatagccc cggatatctg tgttaccagc cttgtctcgg ccacctcaag    600

gataatcact aaattctgcc gaaaggactg aggaacggtg cctggaaaag ggcaagaata    660

tcacggcatg ggcatgagta gcttgaaact gctgaagtat gtcctgtttt tcttcaactt    720

gctcttttgg gtaagtgtat ctcttctgag cacggtttag ctcaccttta cccagctaag    780

ctctcctcat tcctctactg aagaggctgg tgtggggtaa aatgcatgcg tgtttgggtc    840

atgtccagca caaccatcct agaaacaaaa gagtaataat ttttcccctc ttcctgccac    900

agaataaacc tgcaaaattg aaaggtacca gtgcagttat taatggaggt gctgtttctc    960

tctgagggct ttagtttact actactcgta gctaacatat ataggtgaga aacctgagac   1020

tgtgctctgg atattgagtg cctctgtttt tcttgtcttt ttttctagat tccttgaaac   1080

aataagtgat tgaaaggaaa gtcacccttt ccagggaggt ttcactgtat aaaattcagc   1140

aattgaattt cagatatagg atgggttggt acttgtgtat atgagaagat tattataagt   1200

ttggcttctc tagttttctg cctagcaaga tgagcttcct caagcagggc atcttctcta   1260

catggtcatg gtttctacag agaaagccat gtgtgagcga ctg                     1303


<210>  659
<211>  47
<212>  PRT
<213>  Homo sapiens

<400>  659


Met His Ala Cys Leu Gly His Val Gln His Asn His Pro Arg Asn Lys 
1               5                   10                  15      


Arg Val Ile Ile Phe Pro Leu Phe Leu Pro Gln Asn Lys Pro Ala Lys 
            20                  25                  30          


Leu Lys Gly Thr Ser Ala Val Ile Asn Gly Gly Ala Val Ser Leu 
        35                  40                  45          

<210>  660
<211>  1001
<212>  DNA
<213>  Homo sapiens

<400>  660
agtcttgctc tcgagacaga gaagtctgca aatggtgtcc aattcaagtc tagagactgg     60

ctgaagccag acagagggag tatgaggagg gggcagagaa tcttcagaaa gacattccaa    120

agtctcgggc ctagaaaatg tttagaaata ttggttcctg tgttcccctc cagtctgtct    180

acctgaatgg gaaactggtg gtggggccag gcatacttct ttttgaacaa atacacagtt    240

aattctgaga tgccaccttg attgagaagc actgtccttt tctaagcaaa aatcattgcc    300

aaattaccct agaatccacc actgctcaca gatctgtgcc tgaaccaact tggttttgaa    360

gttttctttt gtttcacaaa actagtttag ggtgggctgt gagaggaagc ttctaaaaag    420

ccactgggaa agtactaaat ctctgagact aaagagggcg gactcagcct cacttcctcc    480

ttcttctcat ctgggcttcc tgtcgtcaca gcatgatcat attttttcac ccttcacttc    540

tccttttaca caaatagccc cggatatctg tgttaccagc cttgtctcgg ccacctcaag    600

gataatcact aaattctgcc gaaaggactg aggaacggtg cctggaaaag ggcaagaata    660

tcacggcatg ggcatgagta gcttgaaact gctgaagtat gtcctgtttt tcttcaactt    720

gctcttttgg attccttgaa acaataagtg attgaaagga aagtcaccct ttccagggag    780

gtttcactgt ataaaattca gcaattgaat ttcagatata ggatgggttg gtacttgtgt    840

atatgagaag attattataa gtttggcttc tctagttttc tgcctagcaa gatgagcttc    900

ctcaagcagg gcatcttctc tacatggtca tggtttctac agagaaagcc atgtgtgagc    960

gactgaaaag ataaggaaaa agaagttaga cctatatatg g                       1001


<210>  661
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  661


Met Arg Arg Gly Gln Arg Ile Phe Arg Lys Thr Phe Gln Ser Leu Gly 
1               5                   10                  15      


Pro Arg Lys Cys Leu Glu Ile Leu Val Pro Val Phe Pro Ser Ser Leu 
            20                  25                  30          


Ser Thr 
        

<210>  662
<211>  1436
<212>  DNA
<213>  Homo sapiens

<400>  662
agtcttgctc tcgagacaga gaagtctgca aatggtgtcc aattcaagtc tagagactgg     60

ctgaagccag acagagggag tatgaggagg gggcagagaa tcttcagaaa gacattccaa    120

agtctcgggc ctagaaaatg tttagaaata ttggttcctg tgttcccctc cagtctgtct    180

acctgaatgg gaaactggtg gtggggccag gcatacttct ttttgaacaa atacacagtt    240

aattctgaga tgccaccttg attgagaagc actgtccttt tctaagcaaa aatcattgcc    300

aaattaccct agaatccacc actgctcaca gatctgtgcc tgaaccaact tggttttgaa    360

gttttctttt gtttcacaaa actagtttag ggtgggctgt gagaggaagc ttctaaaaag    420

ccactgggaa agtactaaat ctctgagact aaagagggcg gactcagcct cacttcctcc    480

ttcttctcat ctgggcttcc tgtcgtcaca gcatgatcat attttttcac ccttcacttc    540

tccttttaca caaatagccc cggatatctg tgttaccagc cttgtctcgg ccacctcaag    600

gataatcact aaattctgcc gaaaggactg aggaacggtg cctggaaaag ggcaagaata    660

tcacggcatg ggcatgagta gcttgaaact gctgaagtat gtcctgtttt tcttcaactt    720

gctcttttgg atctgtggct gctgcatttt gggctttggg atctacctgc tgatccacaa    780

caacttcgga gtgctcttcc ataacctccc ctccctcacg ctgggcaatg tgtttgtcat    840

cgtgggctct attatcatgg tagttgcctt cctgggctgc atgggctcta tcaaggaaaa    900

caagtgtctg cttatgtcgg tgagtcctta cagcagatgt ggtgccccaa gtcggggaga    960

tggtgcctaa atcccaggca agatgtttct tggtagatca cttataggca cagaaagatc   1020

ataggaaaat gagattggta cctcagatca gccaagtctg cccagaccaa tagtatatta   1080

tgtatgacta gggtcccacg gacaggtgaa agagggcatt gctatccccc ttgtagccat   1140

ttttatattg ctaataatga cttttgtcat tattgtaatt cccctttata gcattttatt   1200

ttttctttat gtctggatga aatcaggtgt catccatctt ccaaaatcct cctcatgcta   1260

gctattatta tgtactttca gattctgact gagagtcgct aactaatgga aaataatttc   1320

taggctcttt cctccccaaa tgccaaagga tgcttcctta actcatgtct gcacaagata   1380

ctccgtagag agatccaact taggtgaggg ctctggctgc agccattgag gtctaa       1436


<210>  663
<211>  100
<212>  PRT
<213>  Homo sapiens

<400>  663


Met Gly Met Ser Ser Leu Lys Leu Leu Lys Tyr Val Leu Phe Phe Phe 
1               5                   10                  15      


Asn Leu Leu Phe Trp Ile Cys Gly Cys Cys Ile Leu Gly Phe Gly Ile 
            20                  25                  30          


Tyr Leu Leu Ile His Asn Asn Phe Gly Val Leu Phe His Asn Leu Pro 
        35                  40                  45              


Ser Leu Thr Leu Gly Asn Val Phe Val Ile Val Gly Ser Ile Ile Met 
    50                  55                  60                  


Val Val Ala Phe Leu Gly Cys Met Gly Ser Ile Lys Glu Asn Lys Cys 
65                  70                  75                  80  


Leu Leu Met Ser Val Ser Pro Tyr Ser Arg Cys Gly Ala Pro Ser Arg 
                85                  90                  95      


Gly Asp Gly Ala 
            100 

<210>  664
<211>  1809
<212>  DNA
<213>  Homo sapiens

<400>  664
agtcttgctc tcgagacaga gaagtctgca aatggtgtcc aattcaagtc tagagactgg     60

ctgaagccag acagagggag tatgaggagg gggcagagaa tcttcagaaa gacattccaa    120

agtctcgggc ctagaaaatg tttagaaata ttggttcctg tgttcccctc cagtctgtct    180

acctgaatgg gaaactggtg gtggggccag gcatacttct ttttgaacaa atacacagtt    240

aattctgaga tgccaccttg attgagaagc actgtccttt tctaagcaaa aatcattgcc    300

aaattaccct agaatccacc actgctcaca gatctgtgcc tgaaccaact tggttttgaa    360

gttttctttt gtttcacaaa actagtttag ggtgggctgt gagaggaagc ttctaaaaag    420

ccactgggaa agtactaaat ctctgagact aaagagggcg gactcagcct cacttcctcc    480

ttcttctcat ctgggcttcc tgtcgtcaca gcatgatcat attttttcac ccttcacttc    540

tccttttaca caaatagccc cggatatctg tgttaccagc cttgtctcgg ccacctcaag    600

gataatcact aaattctgcc gaaaggactg aggaacggtg cctggaaaag ggcaagaata    660

tcacggcatg ggcatgagta gcttgaaact gctgaagtat gtcctgtttt tcttcaactt    720

gctctttgta tatgaacaga agctgaatga gtatgtggct aagggtctga ccgacagcat    780

ccaccgttac cactcagaca atagcaccaa ggcagcgtgg gactccatcc agtcatttct    840

gcagtgttgt ggtataaatg gcacgagtga ttggaccagt ggcccaccag catcttgccc    900

ctcagatcga aaagtggagg gttgctatgc gaaagcaaga ctgtggtttc attccaattt    960

cctgtatatc ggaatcatca ccatctgtgt atgtgtgatt gaggtgttgg ggatgtcctt   1020

tgcactgacc ctgaactgcc agattgacaa aaccagccag accatagggc tatgatctgc   1080

agtagtcctg tggtgaagag acttgtttca tctccggaaa tgcaaaacca tttatagcat   1140

gaagccctac atgatcactg caggatgatc ctcctcccat cctttccctt tttaggtccc   1200

tgtcttatac aaccagagaa gtgggtgttg gccaggcaca tcccatctca ggcagcaaga   1260

caatctttca ctcactgacg gcagcagcca tgtctctcaa agtggtgaaa ctaatatctg   1320

agcatctttt agacaagaga ggcaaagaca aactggattt aatggcccaa catcaaaggg   1380

tgaacccagg atatgaattt ttgcatcttc ccattgtcga attagtctcc agcctctaaa   1440

taatgcccag tcttctcccc aaagtcaagc aagagactag ttgaagggag ttctggggcc   1500

aggctcactg gaccattgtc acaaccctct gtttctcttt gactaagtgc cctggctaca   1560

ggaattacac agttctcttt ctccaaaggg caagatctca tttcaatttc tttattagag   1620

ggccttattg atgtgttcta agtctttcca gaaaaaaact atccagtgat ttatatcctg   1680

atttcaacca gtcacttagc tgataatcac agtaagaaga cttctggtat tatctctcta   1740

tcagataaga ttttgttaat gtactatttt actcttcaat aaataaaagt ttattatctc   1800

aatcacaac                                                           1809


<210>  665
<211>  135
<212>  PRT
<213>  Homo sapiens

<400>  665


Met Gly Met Ser Ser Leu Lys Leu Leu Lys Tyr Val Leu Phe Phe Phe 
1               5                   10                  15      


Asn Leu Leu Phe Val Tyr Glu Gln Lys Leu Asn Glu Tyr Val Ala Lys 
            20                  25                  30          


Gly Leu Thr Asp Ser Ile His Arg Tyr His Ser Asp Asn Ser Thr Lys 
        35                  40                  45              


Ala Ala Trp Asp Ser Ile Gln Ser Phe Leu Gln Cys Cys Gly Ile Asn 
    50                  55                  60                  


Gly Thr Ser Asp Trp Thr Ser Gly Pro Pro Ala Ser Cys Pro Ser Asp 
65                  70                  75                  80  


Arg Lys Val Glu Gly Cys Tyr Ala Lys Ala Arg Leu Trp Phe His Ser 
                85                  90                  95      


Asn Phe Leu Tyr Ile Gly Ile Ile Thr Ile Cys Val Cys Val Ile Glu 
            100                 105                 110         


Val Leu Gly Met Ser Phe Ala Leu Thr Leu Asn Cys Gln Ile Asp Lys 
        115                 120                 125             


Thr Ser Gln Thr Ile Gly Leu 
    130                 135 

<210>  666
<211>  2141
<212>  DNA
<213>  Homo sapiens

<400>  666
agtcttgctc tcgagacaga gaagtctgca aatggtgtcc aattcaagtc tagagactgg     60

ctgaagccag acagagggag tatgaggagg gggcagagaa tcttcagaaa gacattccaa    120

agtctcgggc ctagaaaatg tttagaaata ttggttcctg tgttcccctc cagtctgtct    180

acctgaatgg gaaactggtg gtggggccag gcatacttct ttttgaacaa atacacagtt    240

aattctgaga tgccaccttg attgagaagc actgtccttt tctaagcaaa aatcattgcc    300

aaattaccct agaatccacc actgctcaca gatctgtgcc tgaaccaact tggttttgaa    360

gttttctttt gtttcacaaa actagtttag ggtgggctgt gagaggaagc ttctaaaaag    420

ccactgggaa agtactaaat ctctgagact aaagagggcg gactcagcct cacttcctcc    480

ttcttctcat ctgggcttcc tgtcgtcaca gcatgatcat attttttcac ccttcacttc    540

tccttttaca caaatagccc cggatatctg tgttaccagc cttgtctcgg ccacctcaag    600

gataatcact aaattctgcc gaaaggactg aggaacggtg cctggaaaag ggcaagaata    660

tcacggcatg ggcatgagta gcttgaaact gctgaagtat gtcctgtttt tcttcaactt    720

gctctttgta tatgaacaga agctgaatga gtatgtggct aagggtctga ccgacagcat    780

ccaccgttac cactcagaca atagcaccaa ggcagcgtgg gactccatcc agtcatttct    840

gcagtgttgt ggtataaatg gcacgagtga ttggaccagt ggcccaccag catcttgccc    900

ctcagatcga aaagtggagg gttgctatgc gaaagcaaga ctgtggtttc attccaattt    960

cctgtatatc ggaatcatca ccatctgtgt atgtgtgatt gaggtgttgg ggatgtcctt   1020

tgcactgacc ctgaactgcc agattgacaa aaccagccag accatagggc tatgatctgc   1080

agtagtcctg tggtgaagag acttgtttca tctccggaaa tgcaaaacca tttatagcat   1140

gaagccctac atgatcactg caggatgatc ctcctcccat cctttccctt tttaggtccc   1200

tgtcttatac aaccagagaa gtgggtgttg gccaggcaca tcccatctca ggcagcaaga   1260

caatctttca ctcactgacg gcagcagcca tgtctctcaa agtggtgaaa ctaatatctg   1320

agcatctttt agacaagaga ggcaaagaca aactggattt aatggcccaa catcaaaggg   1380

tgaacccagg atatgaattt ttgcatcttc ccattgtcga attagtctcc agcctctaaa   1440

taatgcccag tcttctcccc aaagtcaagc aagagactag ttgaagggag ttctggggcc   1500

aggctcactg gaccattgtc acaaccctct gtttctcttt gactaagtgc cctggctaca   1560

ggaattacac agttctcttt ctccaaaggg caagatctca tttcaatttc tttattagag   1620

ggccttattg atgtgttcta agtctttcca gaaaaaaact atccagtgat ttatatcctg   1680

atttcaacca gtcacttagc tgataatcac agtaagaaga cttctggtat tatctctcta   1740

tcagataaga ttttgttaat gtactatttt actcttcaat aaataaaagt ttattatctc   1800

aatcacaaca ttgctatata tcaaacactc cttccatgac ccagcctgat taccctgatt   1860

aatgcaccaa accaggtgta ttaattgtct cctgctgcat aaaatattac tccaaaattt   1920

agtggctgag gacaacaaac atttattatc tcatggtttt tgtgggtcag gaatctagga   1980

gcagcttagc tgggtgattc tggttcacag tctctcatgt aactgcaatc aacatgtcag   2040

cctgggctgc agtaacctta aggctcaact gaaagaggat ctactttcag gctctctcac   2100

atcgctgttg gcaagcctca gatctttgcc acttgtgcct t                       2141


<210>  667
<211>  135
<212>  PRT
<213>  Homo sapiens

<400>  667


Met Gly Met Ser Ser Leu Lys Leu Leu Lys Tyr Val Leu Phe Phe Phe 
1               5                   10                  15      


Asn Leu Leu Phe Val Tyr Glu Gln Lys Leu Asn Glu Tyr Val Ala Lys 
            20                  25                  30          


Gly Leu Thr Asp Ser Ile His Arg Tyr His Ser Asp Asn Ser Thr Lys 
        35                  40                  45              


Ala Ala Trp Asp Ser Ile Gln Ser Phe Leu Gln Cys Cys Gly Ile Asn 
    50                  55                  60                  


Gly Thr Ser Asp Trp Thr Ser Gly Pro Pro Ala Ser Cys Pro Ser Asp 
65                  70                  75                  80  


Arg Lys Val Glu Gly Cys Tyr Ala Lys Ala Arg Leu Trp Phe His Ser 
                85                  90                  95      


Asn Phe Leu Tyr Ile Gly Ile Ile Thr Ile Cys Val Cys Val Ile Glu 
            100                 105                 110         


Val Leu Gly Met Ser Phe Ala Leu Thr Leu Asn Cys Gln Ile Asp Lys 
        115                 120                 125             


Thr Ser Gln Thr Ile Gly Leu 
    130                 135 

<210>  668
<211>  1168
<212>  DNA
<213>  Homo sapiens

<400>  668
actgcccagt aacagtgaaa aggggaaggg gaaacggagc agcattctct ctggggccct     60

tatggcatgt ggcaaaagta gtgacatcct tagggcaaga atatcacggc atgggcatga    120

gtagcttgaa actgctgaag tatgtcctgt ttttcttcaa cttgctcttt tggatctgtg    180

gctgctgcat tttgggcttt gggatctacc tgctgatcca caacaacttc ggagtgctct    240

tccataacct cccctccctc acgctgggca atgtgtttgt catcgtgggc tctattatca    300

tggtagttgc cttcctgggc tgcatgggct ctatcaagga aaacaagtgt ctgcttatgt    360

cggtgttggg gatgtccttt gcactgaccc tgaactgcca gattgacaaa accagccaga    420

ccatagggct atgatctgca gtagtcctgt ggtgaagaga cttgtttcat ctccggaaat    480

gcaaaaccat ttatagcatg aagccctaca tgatcactgc aggatgatcc tcctcccatc    540

ctttcccttt ttaggtccct gtcttataca accagagaag tgggtgttgg ccaggcacat    600

cccatctcag gcagcaagac aatctttcac tcactgacgg cagcagccat gtctctcaaa    660

gtggtgaaac taatatctga gcatctttta gacaagagag gcaaagacaa actggattta    720

atggcccaac atcaaagggt gaacccagga tatgaatttt tgcatcttcc cattgtcgaa    780

ttagtctcca gcctctaaat aatgcccagt cttctcccca aagtcaagca agagactagt    840

tgaagggagt tctggggcca ggctcactgg accattgtca caaccctctg tttctctttg    900

actaagtgcc ctggctacag gaattacaca gttctctttc tccaaagggc aagatctcat    960

ttcaatttct ttattagagg gccttattga tgtgttctaa gtctttccag aaaaaaacta   1020

tccagtgatt tatatcctga tttcaaccag tcacttagct gataatcaca gtaagaagac   1080

ttctggtatt atctctctat cagataagat tttgttaatg tactatttta ctcttcaata   1140

aataaaagtt tattatctca atcacaac                                      1168


<210>  669
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  669


Met Gly Met Ser Ser Leu Lys Leu Leu Lys Tyr Val Leu Phe Phe Phe 
1               5                   10                  15      


Asn Leu Leu Phe Trp Ile Cys Gly Cys Cys Ile Leu Gly Phe Gly Ile 
            20                  25                  30          


Tyr Leu Leu Ile His Asn Asn Phe Gly Val Leu Phe His Asn Leu Pro 
        35                  40                  45              


Ser Leu Thr Leu Gly Asn Val Phe Val Ile Val Gly Ser Ile Ile Met 
    50                  55                  60                  


Val Val Ala Phe Leu Gly Cys Met Gly Ser Ile Lys Glu Asn Lys Cys 
65                  70                  75                  80  


Leu Leu Met Ser Val Leu Gly Met Ser Phe Ala Leu Thr Leu Asn Cys 
                85                  90                  95      


Gln Ile Asp Lys Thr Ser Gln Thr Ile Gly Leu 
            100                 105         

<210>  670
<211>  1500
<212>  DNA
<213>  Homo sapiens

<400>  670
actgcccagt aacagtgaaa aggggaaggg gaaacggagc agcattctct ctggggccct     60

tatggcatgt ggcaaaagta gtgacatcct tagggcaaga atatcacggc atgggcatga    120

gtagcttgaa actgctgaag tatgtcctgt ttttcttcaa cttgctcttt tggatctgtg    180

gctgctgcat tttgggcttt gggatctacc tgctgatcca caacaacttc ggagtgctct    240

tccataacct cccctccctc acgctgggca atgtgtttgt catcgtgggc tctattatca    300

tggtagttgc cttcctgggc tgcatgggct ctatcaagga aaacaagtgt ctgcttatgt    360

cggtgttggg gatgtccttt gcactgaccc tgaactgcca gattgacaaa accagccaga    420

ccatagggct atgatctgca gtagtcctgt ggtgaagaga cttgtttcat ctccggaaat    480

gcaaaaccat ttatagcatg aagccctaca tgatcactgc aggatgatcc tcctcccatc    540

ctttcccttt ttaggtccct gtcttataca accagagaag tgggtgttgg ccaggcacat    600

cccatctcag gcagcaagac aatctttcac tcactgacgg cagcagccat gtctctcaaa    660

gtggtgaaac taatatctga gcatctttta gacaagagag gcaaagacaa actggattta    720

atggcccaac atcaaagggt gaacccagga tatgaatttt tgcatcttcc cattgtcgaa    780

ttagtctcca gcctctaaat aatgcccagt cttctcccca aagtcaagca agagactagt    840

tgaagggagt tctggggcca ggctcactgg accattgtca caaccctctg tttctctttg    900

actaagtgcc ctggctacag gaattacaca gttctctttc tccaaagggc aagatctcat    960

ttcaatttct ttattagagg gccttattga tgtgttctaa gtctttccag aaaaaaacta   1020

tccagtgatt tatatcctga tttcaaccag tcacttagct gataatcaca gtaagaagac   1080

ttctggtatt atctctctat cagataagat tttgttaatg tactatttta ctcttcaata   1140

aataaaagtt tattatctca atcacaacat tgctatatat caaacactcc ttccatgacc   1200

cagcctgatt accctgatta atgcaccaaa ccaggtgtat taattgtctc ctgctgcata   1260

aaatattact ccaaaattta gtggctgagg acaacaaaca tttattatct catggttttt   1320

gtgggtcagg aatctaggag cagcttagct gggtgattct ggttcacagt ctctcatgta   1380

actgcaatca acatgtcagc ctgggctgca gtaaccttaa ggctcaactg aaagaggatc   1440

tactttcagg ctctctcaca tcgctgttgg caagcctcag atctttgcca cttgtgcctt   1500


<210>  671
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  671


Met Gly Met Ser Ser Leu Lys Leu Leu Lys Tyr Val Leu Phe Phe Phe 
1               5                   10                  15      


Asn Leu Leu Phe Trp Ile Cys Gly Cys Cys Ile Leu Gly Phe Gly Ile 
            20                  25                  30          


Tyr Leu Leu Ile His Asn Asn Phe Gly Val Leu Phe His Asn Leu Pro 
        35                  40                  45              


Ser Leu Thr Leu Gly Asn Val Phe Val Ile Val Gly Ser Ile Ile Met 
    50                  55                  60                  


Val Val Ala Phe Leu Gly Cys Met Gly Ser Ile Lys Glu Asn Lys Cys 
65                  70                  75                  80  


Leu Leu Met Ser Val Leu Gly Met Ser Phe Ala Leu Thr Leu Asn Cys 
                85                  90                  95      


Gln Ile Asp Lys Thr Ser Gln Thr Ile Gly Leu 
            100                 105         

<210>  672
<211>  1327
<212>  DNA
<213>  Homo sapiens

<400>  672
agggcaagaa tatcacggca tgggcatgag tagcttgaaa ctgctgaagt atgtcctgtt     60

tttcttcaac ttgctctttt ggatctgtgg ctgctgcatt ttgggctttg ggctctatta    120

tcatggtagt tgccttcctg ggctgcatgg gctctatcaa ggaaaacaag tgtctgctta    180

tgtcgttctt catcctgctg ctgattatcc tccttgctga ggtgaccttg gccatcctgc    240

tctttgtata tgaacagaag ctgaatgagt atgtggctaa gggtctgacc gacagcatcc    300

accgttacca ctcagacaat agcaccaagg cagcgtggga ctccatccag tcatttctgc    360

agtgttgtgg tataaatggc acgagtgatt ggaccagtgg cccaccagca tcttgcccct    420

cagatcgaaa agtggagggt tgctatgcga aagcaagact gtggtttcat tccaatttcc    480

tgtatatcgg aatcatcacc atctgtgtat gtgtgattga ggtgttgggg atgtcctttg    540

cactgaccct gaactgccag attgacaaaa ccagccagac catagggcta tgatctgcag    600

tagtcctgtg gtgaagagac ttgtttcatc tccggaaatg caaaaccatt tatagcatga    660

agccctacat gatcactgca ggatgatcct cctcccatcc tttccctttt taggtccctg    720

tcttatacaa ccagagaagt gggtgttggc caggcacatc ccatctcagg cagcaagaca    780

atctttcact cactgacggc agcagccatg tctctcaaag tggtgaaact aatatctgag    840

catcttttag acaagagagg caaagacaaa ctggatttaa tggcccaaca tcaaagggtg    900

aacccaggat atgaattttt gcatcttccc attgtcgaat tagtctccag cctctaaata    960

atgcccagtc ttctccccaa agtcaagcaa gagactagtt gaagggagtt ctggggccag   1020

gctcactgga ccattgtcac aaccctctgt ttctctttga ctaagtgccc tggctacagg   1080

aattacacag ttctctttct ccaaagggca agatctcatt tcaatttctt tattagaggg   1140

ccttattgat gtgttctaag tctttccaga aaaaaactat ccagtgattt atatcctgat   1200

ttcaaccagt cacttagctg ataatcacag taagaagact tctggtatta tctctctatc   1260

agataagatt ttgttaatgt actattttac tcttcaataa ataaaagttt attatctcaa   1320

tcacaac                                                             1327


<210>  673
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  673


Met Ser Cys Phe Ser Ser Thr Cys Ser Phe Gly Ser Val Ala Ala Ala 
1               5                   10                  15      


Phe Trp Ala Leu Gly Ser Ile Ile Met Val Val Ala Phe Leu Gly Cys 
            20                  25                  30          


Met Gly Ser Ile Lys Glu Asn Lys Cys Leu Leu Met Ser Phe Phe Ile 
        35                  40                  45              


Leu Leu Leu Ile Ile Leu Leu Ala Glu Val Thr Leu Ala Ile Leu Leu 
    50                  55                  60                  


Phe Val Tyr Glu Gln Lys Leu Asn Glu Tyr Val Ala Lys Gly Leu Thr 
65                  70                  75                  80  


Asp Ser Ile His Arg Tyr His Ser Asp Asn Ser Thr Lys Ala Ala Trp 
                85                  90                  95      


Asp Ser Ile Gln Ser Phe Leu Gln Cys Cys Gly Ile Asn Gly Thr Ser 
            100                 105                 110         


Asp Trp Thr Ser Gly Pro Pro Ala Ser Cys Pro Ser Asp Arg Lys Val 
        115                 120                 125             


Glu Gly Cys Tyr Ala Lys Ala Arg Leu Trp Phe His Ser Asn Phe Leu 
    130                 135                 140                 


Tyr Ile Gly Ile Ile Thr Ile Cys Val Cys Val Ile Glu Val Leu Gly 
145                 150                 155                 160 


Met Ser Phe Ala Leu Thr Leu Asn Cys Gln Ile Asp Lys Thr Ser Gln 
                165                 170                 175     


Thr Ile Gly Leu 
            180 

<210>  674
<211>  1413
<212>  DNA
<213>  Homo sapiens

<400>  674
agggcaagaa tatcacggca tgggcatgag tagcttgaaa ctgctgaagt atgtcctgtt     60

tttcttcaac ttgctctttt ggatctgtgg ctgctgcatt ttgggctttg ggatctacct    120

gctgatccac aacaacttcg gagtgctctt ccataacctc ccctccctca cgctgggcaa    180

tgtgtttgtc atcgtgggct ctattatcat ggtagttgcc ttcctgggct gcatgggctc    240

tatcaaggaa aacaagtgtc tgcttatgtc gttcttcatc ctgctgctga ttatcctcct    300

tgctgaggtg accttggcca tcctgctctt tgtatatgaa cagaagctga atgagtatgt    360

ggctaagggt ctgaccgaca gcatccaccg ttaccactca gacaatagca ccaaggcagc    420

gtgggactcc atccagtcat ttctgcagtg ttgtggtata aatggcacga gtgattggac    480

cagtggccca ccagcatctt gcccctcaga tcgaaaagtg gagggttgct atgcgaaagc    540

aagactgtgg tttcattcca atttcctgta tatcggaatc atcaccatct gtgtatgtgt    600

gattgaggtg ttggggatgt cctttgcact gaccctgaac tgccagattg acaaaaccag    660

ccagaccata gggctatgat ctgcagtagt cctgtggtga agagacttgt ttcatctccg    720

gaaatgcaaa accatttata gcatgaagcc ctacatgatc actgcaggat gatcctcctc    780

ccatcctttc cctttttagg tccctgtctt atacaaccag agaagtgggt gttggccagg    840

cacatcccat ctcaggcagc aagacaatct ttcactcact gacggcagca gccatgtctc    900

tcaaagtggt gaaactaata tctgagcatc ttttagacaa gagaggcaaa gacaaactgg    960

atttaatggc ccaacatcaa agggtgaacc caggatatga atttttgcat cttcccattg   1020

tcgaattagt ctccagcctc taaataatgc ccagtcttct ccccaaagtc aagcaagaga   1080

ctagttgaag ggagttctgg ggccaggctc actggaccat tgtcacaacc ctctgtttct   1140

ctttgactaa gtgccctggc tacaggaatt acacagttct ctttctccaa agggcaagat   1200

ctcatttcaa tttctttatt agagggcctt attgatgtgt tctaagtctt tccagaaaaa   1260

aactatccag tgatttatat cctgatttca accagtcact tagctgataa tcacagtaag   1320

aagacttctg gtattatctc tctatcagat aagattttgt taatgtacta ttttactctt   1380

caataaataa aagtttatta tctcaatcac aac                                1413


<210>  675
<211>  219
<212>  PRT
<213>  Homo sapiens

<400>  675


Met Gly Met Ser Ser Leu Lys Leu Leu Lys Tyr Val Leu Phe Phe Phe 
1               5                   10                  15      


Asn Leu Leu Phe Trp Ile Cys Gly Cys Cys Ile Leu Gly Phe Gly Ile 
            20                  25                  30          


Tyr Leu Leu Ile His Asn Asn Phe Gly Val Leu Phe His Asn Leu Pro 
        35                  40                  45              


Ser Leu Thr Leu Gly Asn Val Phe Val Ile Val Gly Ser Ile Ile Met 
    50                  55                  60                  


Val Val Ala Phe Leu Gly Cys Met Gly Ser Ile Lys Glu Asn Lys Cys 
65                  70                  75                  80  


Leu Leu Met Ser Phe Phe Ile Leu Leu Leu Ile Ile Leu Leu Ala Glu 
                85                  90                  95      


Val Thr Leu Ala Ile Leu Leu Phe Val Tyr Glu Gln Lys Leu Asn Glu 
            100                 105                 110         


Tyr Val Ala Lys Gly Leu Thr Asp Ser Ile His Arg Tyr His Ser Asp 
        115                 120                 125             


Asn Ser Thr Lys Ala Ala Trp Asp Ser Ile Gln Ser Phe Leu Gln Cys 
    130                 135                 140                 


Cys Gly Ile Asn Gly Thr Ser Asp Trp Thr Ser Gly Pro Pro Ala Ser 
145                 150                 155                 160 


Cys Pro Ser Asp Arg Lys Val Glu Gly Cys Tyr Ala Lys Ala Arg Leu 
                165                 170                 175     


Trp Phe His Ser Asn Phe Leu Tyr Ile Gly Ile Ile Thr Ile Cys Val 
            180                 185                 190         


Cys Val Ile Glu Val Leu Gly Met Ser Phe Ala Leu Thr Leu Asn Cys 
        195                 200                 205             


Gln Ile Asp Lys Thr Ser Gln Thr Ile Gly Leu 
    210                 215                 

<210>  676
<211>  1659
<212>  DNA
<213>  Homo sapiens

<400>  676
agggcaagaa tatcacggca tgggcatgag tagcttgaaa ctgctgaagt atgtcctgtt     60

tttcttcaac ttgctctttt ggatctgtgg ctgctgcatt ttgggctttg ggctctatta    120

tcatggtagt tgccttcctg ggctgcatgg gctctatcaa ggaaaacaag tgtctgctta    180

tgtcgttctt catcctgctg ctgattatcc tccttgctga ggtgaccttg gccatcctgc    240

tctttgtata tgaacagaag ctgaatgagt atgtggctaa gggtctgacc gacagcatcc    300

accgttacca ctcagacaat agcaccaagg cagcgtggga ctccatccag tcatttctgc    360

agtgttgtgg tataaatggc acgagtgatt ggaccagtgg cccaccagca tcttgcccct    420

cagatcgaaa agtggagggt tgctatgcga aagcaagact gtggtttcat tccaatttcc    480

tgtatatcgg aatcatcacc atctgtgtat gtgtgattga ggtgttgggg atgtcctttg    540

cactgaccct gaactgccag attgacaaaa ccagccagac catagggcta tgatctgcag    600

tagtcctgtg gtgaagagac ttgtttcatc tccggaaatg caaaaccatt tatagcatga    660

agccctacat gatcactgca ggatgatcct cctcccatcc tttccctttt taggtccctg    720

tcttatacaa ccagagaagt gggtgttggc caggcacatc ccatctcagg cagcaagaca    780

atctttcact cactgacggc agcagccatg tctctcaaag tggtgaaact aatatctgag    840

catcttttag acaagagagg caaagacaaa ctggatttaa tggcccaaca tcaaagggtg    900

aacccaggat atgaattttt gcatcttccc attgtcgaat tagtctccag cctctaaata    960

atgcccagtc ttctccccaa agtcaagcaa gagactagtt gaagggagtt ctggggccag   1020

gctcactgga ccattgtcac aaccctctgt ttctctttga ctaagtgccc tggctacagg   1080

aattacacag ttctctttct ccaaagggca agatctcatt tcaatttctt tattagaggg   1140

ccttattgat gtgttctaag tctttccaga aaaaaactat ccagtgattt atatcctgat   1200

ttcaaccagt cacttagctg ataatcacag taagaagact tctggtatta tctctctatc   1260

agataagatt ttgttaatgt actattttac tcttcaataa ataaaagttt attatctcaa   1320

tcacaacatt gctatatatc aaacactcct tccatgaccc agcctgatta ccctgattaa   1380

tgcaccaaac caggtgtatt aattgtctcc tgctgcataa aatattactc caaaatttag   1440

tggctgagga caacaaacat ttattatctc atggtttttg tgggtcagga atctaggagc   1500

agcttagctg ggtgattctg gttcacagtc tctcatgtaa ctgcaatcaa catgtcagcc   1560

tgggctgcag taaccttaag gctcaactga aagaggatct actttcaggc tctctcacat   1620

cgctgttggc aagcctcaga tctttgccac ttgtgcctt                          1659


<210>  677
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  677


Met Ser Cys Phe Ser Ser Thr Cys Ser Phe Gly Ser Val Ala Ala Ala 
1               5                   10                  15      


Phe Trp Ala Leu Gly Ser Ile Ile Met Val Val Ala Phe Leu Gly Cys 
            20                  25                  30          


Met Gly Ser Ile Lys Glu Asn Lys Cys Leu Leu Met Ser Phe Phe Ile 
        35                  40                  45              


Leu Leu Leu Ile Ile Leu Leu Ala Glu Val Thr Leu Ala Ile Leu Leu 
    50                  55                  60                  


Phe Val Tyr Glu Gln Lys Leu Asn Glu Tyr Val Ala Lys Gly Leu Thr 
65                  70                  75                  80  


Asp Ser Ile His Arg Tyr His Ser Asp Asn Ser Thr Lys Ala Ala Trp 
                85                  90                  95      


Asp Ser Ile Gln Ser Phe Leu Gln Cys Cys Gly Ile Asn Gly Thr Ser 
            100                 105                 110         


Asp Trp Thr Ser Gly Pro Pro Ala Ser Cys Pro Ser Asp Arg Lys Val 
        115                 120                 125             


Glu Gly Cys Tyr Ala Lys Ala Arg Leu Trp Phe His Ser Asn Phe Leu 
    130                 135                 140                 


Tyr Ile Gly Ile Ile Thr Ile Cys Val Cys Val Ile Glu Val Leu Gly 
145                 150                 155                 160 


Met Ser Phe Ala Leu Thr Leu Asn Cys Gln Ile Asp Lys Thr Ser Gln 
                165                 170                 175     


Thr Ile Gly Leu 
            180 

<210>  678
<211>  1745
<212>  DNA
<213>  Homo sapiens

<400>  678
agggcaagaa tatcacggca tgggcatgag tagcttgaaa ctgctgaagt atgtcctgtt     60

tttcttcaac ttgctctttt ggatctgtgg ctgctgcatt ttgggctttg ggatctacct    120

gctgatccac aacaacttcg gagtgctctt ccataacctc ccctccctca cgctgggcaa    180

tgtgtttgtc atcgtgggct ctattatcat ggtagttgcc ttcctgggct gcatgggctc    240

tatcaaggaa aacaagtgtc tgcttatgtc gttcttcatc ctgctgctga ttatcctcct    300

tgctgaggtg accttggcca tcctgctctt tgtatatgaa cagaagctga atgagtatgt    360

ggctaagggt ctgaccgaca gcatccaccg ttaccactca gacaatagca ccaaggcagc    420

gtgggactcc atccagtcat ttctgcagtg ttgtggtata aatggcacga gtgattggac    480

cagtggccca ccagcatctt gcccctcaga tcgaaaagtg gagggttgct atgcgaaagc    540

aagactgtgg tttcattcca atttcctgta tatcggaatc atcaccatct gtgtatgtgt    600

gattgaggtg ttggggatgt cctttgcact gaccctgaac tgccagattg acaaaaccag    660

ccagaccata gggctatgat ctgcagtagt cctgtggtga agagacttgt ttcatctccg    720

gaaatgcaaa accatttata gcatgaagcc ctacatgatc actgcaggat gatcctcctc    780

ccatcctttc cctttttagg tccctgtctt atacaaccag agaagtgggt gttggccagg    840

cacatcccat ctcaggcagc aagacaatct ttcactcact gacggcagca gccatgtctc    900

tcaaagtggt gaaactaata tctgagcatc ttttagacaa gagaggcaaa gacaaactgg    960

atttaatggc ccaacatcaa agggtgaacc caggatatga atttttgcat cttcccattg   1020

tcgaattagt ctccagcctc taaataatgc ccagtcttct ccccaaagtc aagcaagaga   1080

ctagttgaag ggagttctgg ggccaggctc actggaccat tgtcacaacc ctctgtttct   1140

ctttgactaa gtgccctggc tacaggaatt acacagttct ctttctccaa agggcaagat   1200

ctcatttcaa tttctttatt agagggcctt attgatgtgt tctaagtctt tccagaaaaa   1260

aactatccag tgatttatat cctgatttca accagtcact tagctgataa tcacagtaag   1320

aagacttctg gtattatctc tctatcagat aagattttgt taatgtacta ttttactctt   1380

caataaataa aagtttatta tctcaatcac aacattgcta tatatcaaac actccttcca   1440

tgacccagcc tgattaccct gattaatgca ccaaaccagg tgtattaatt gtctcctgct   1500

gcataaaata ttactccaaa atttagtggc tgaggacaac aaacatttat tatctcatgg   1560

tttttgtggg tcaggaatct aggagcagct tagctgggtg attctggttc acagtctctc   1620

atgtaactgc aatcaacatg tcagcctggg ctgcagtaac cttaaggctc aactgaaaga   1680

ggatctactt tcaggctctc tcacatcgct gttggcaagc ctcagatctt tgccacttgt   1740

gcctt                                                               1745


<210>  679
<211>  219
<212>  PRT
<213>  Homo sapiens

<400>  679


Met Gly Met Ser Ser Leu Lys Leu Leu Lys Tyr Val Leu Phe Phe Phe 
1               5                   10                  15      


Asn Leu Leu Phe Trp Ile Cys Gly Cys Cys Ile Leu Gly Phe Gly Ile 
            20                  25                  30          


Tyr Leu Leu Ile His Asn Asn Phe Gly Val Leu Phe His Asn Leu Pro 
        35                  40                  45              


Ser Leu Thr Leu Gly Asn Val Phe Val Ile Val Gly Ser Ile Ile Met 
    50                  55                  60                  


Val Val Ala Phe Leu Gly Cys Met Gly Ser Ile Lys Glu Asn Lys Cys 
65                  70                  75                  80  


Leu Leu Met Ser Phe Phe Ile Leu Leu Leu Ile Ile Leu Leu Ala Glu 
                85                  90                  95      


Val Thr Leu Ala Ile Leu Leu Phe Val Tyr Glu Gln Lys Leu Asn Glu 
            100                 105                 110         


Tyr Val Ala Lys Gly Leu Thr Asp Ser Ile His Arg Tyr His Ser Asp 
        115                 120                 125             


Asn Ser Thr Lys Ala Ala Trp Asp Ser Ile Gln Ser Phe Leu Gln Cys 
    130                 135                 140                 


Cys Gly Ile Asn Gly Thr Ser Asp Trp Thr Ser Gly Pro Pro Ala Ser 
145                 150                 155                 160 


Cys Pro Ser Asp Arg Lys Val Glu Gly Cys Tyr Ala Lys Ala Arg Leu 
                165                 170                 175     


Trp Phe His Ser Asn Phe Leu Tyr Ile Gly Ile Ile Thr Ile Cys Val 
            180                 185                 190         


Cys Val Ile Glu Val Leu Gly Met Ser Phe Ala Leu Thr Leu Asn Cys 
        195                 200                 205             


Gln Ile Asp Lys Thr Ser Gln Thr Ile Gly Leu 
    210                 215                 

<210>  680
<211>  5736
<212>  DNA
<213>  Homo sapiens

<400>  680
gccttcccac cccccgccct tccactatgg ccgcttctgt gtggtgtggg gagacgctgg     60

tcctccccgt cctcccatag cgcttattgc ctcaccctca ccccctaggg gccggatcca    120

aaggcgctgc actccccaag ccttggggca tcagccagga aggtttccta cctcctaatt    180

caggggcagg actcctcttt tccccccacg gggaaaagag gcagaaactt aggggtttcc    240

ctcctttctt agggtcagac gctcttaggg tccacttctt caggggcgga agcctctcct    300

acccttccca tagggacaca ggcctttacc ccactgtact tcggagccaa cgcctttccc    360

tcagcactgc caccccagag tcaggaccca gaggactgtg ccttcgcccc caacgcaggc    420

gcggcctttt ggagaggagg gaggagtgga gaggacaggg gcccttgctc tcccctcccc    480

aacttgttcc tcttgccccc cagtccctgg caatccagag atcccgatat ctaggactgt    540

ccatccatcc actccctgac cttttcccgg ctcctggctg cagccatgga gttgcagaag    600

ggaaaagggg cggcagcagc agcagctgct tcgggagcag cgggaggtgg aggaggagga    660

gcgggagcag gagccccagg aggggggagg ctgctacttt caaccagttt ggatgccaag    720

gatgagttag aggagagatt ggaaaggtgt atgagcattg tgacatcgat gactgctggt    780

gtctcggaga gagaagccaa tgatgccctc aatgcgtatg tgtgcaaagg cctcccccag    840

catgaagaaa tctgcctggg cctgtttact ctcatcctca ctgaacctgc ccaagcccag    900

aagtgttacc gggacttagc tctggtgagt cgtgatggca tgaatattgt cctgaataaa    960

atcaaccaga tacttatgga gaagtacctg aagctgcagg atacctgccg tactcaggta   1020

aggccagaaa gaaaagacaa gatccagctc aaagagagag gatggatctt ctctctgtca   1080

ggaacgggaa agaggaatca gggctaacac acccctatca ttgtgtgtct aaattgtaat   1140

gtgctccttt cagttgtaat tgaattagct cccttctcaa actcacagtt cctgctcttc   1200

atctgttttt ccctctttcc tttagttggt gtggttggta cgggaactgg tgaagagtgg   1260

ggttctggga gccgatggtg tttgtatgac gtttatgaag cagattgcag gtgagtttga   1320

tggcaggagc ataaagaaga aaggaggaga gcccagagac tacatagaga caatggagaa   1380

tgattaagtg ccaaagggat ggaattcttg gattgcttag actgtttcct tctgatacag   1440

acatcttctg gccacatatg ttgtagaaat aaattgattg aaaaatcatg gggggccttt   1500

taaagcagta agtcttgcct cattttcttt cctgctaaac ccagggcttg acagaatatt   1560

tggcctattt tagccagtct tcactctgag attttatagc atttcagagc aggaagaaat   1620

ggggagagaa gtgagggcaa ttaatttgtt ctcaagtccc tgtgctttca gaaacctaga   1680

catcttccct ggctccaccc ccattatctg aacgcttgct ccctaataat taagcccttt   1740

actggggcca gaatgaggga caaactatgt cacagaacag accctgacat ttaggtttta   1800

ttctcatctt ggcatcggtg acatctgtct gagctatcgc atattcaagc ggctactccc   1860

aagattgcat gtgtttgttt aaaagtgacc tgctactacc tcaccattag cccactggga   1920

cttgcttcct ctttaaaatt ttatgtaaca ctgatgctcc tgttttgatg tgtatgaacc   1980

ttaatctatg tgatatgtga ctttgtgaac attgaatttt ttaattgaga cctggggcaa   2040

ggcatagttg tagctatttt tatcctcttt cctggcactt cttccctgtt tggcacttcc   2100

agcccctgct tcttatccca agactggtat ggcattgctg tgtgttaatt ctgccccaca   2160

gagtttcata gcaagcacta aagactgtta cctggaaata agaaactctt ggcctgttgg   2220

gggcctcagt gcaggactca ggacatccag ttgctagact gcagctgttg tcagccacct   2280

gtacttctca ggctctatct gagatatcat cctttctttc caactgtggg cttcttatat   2340

ctacttctca gacgttcatt ttcaagggcc aaaatgttcc cactccaact cacaatctgt   2400

gggaaagtag cagctctggt ttctagaaaa attcagaacc ttccctttcc ttctttctgg   2460

aggcaaaggg tgaaacttta aagcctgaca gaacagaagg cagtttatct cagcagtgaa   2520

gggatggcag taatgggatg gcagtcaggg tggaccagca gaatgggtga agagatgtat   2580

tggattggct gacttgctaa tcggagctat tctttttttc cccttttgaa atcaggtgga   2640

gatgttacag ccaaaaatat ctggttggca gaaagtgttc tggatatcct gacagagcaa   2700

agggagtggg tcctgaagag cagcatcctc attgccatgg ctgtttacac gtacctccgc   2760

ctcatcgtgg accaccatgg gactgcccag ctccaggccc tgcgacagaa ggaagtagac   2820

ttctgcatct cactgcttcg ggaacggttc atggaatgtc tgatgattgg tcgggatctc   2880

gtaagactac ttcagaatgt tgctaggata ccagaatttg aactgctttg gaaagatatt   2940

atccataatc ctcaggcctt gagtcctcag ttcacaggta tcctacagct tcttcagtca   3000

agaacatccc gaaaattcct agcatgtcgt ctaaccccgg acatggagac taaactcctc   3060

ttcatgacat cccgggtgcg atttggtcaa caaaagcgat accaagattg gttccagcgc   3120

cagtacctgt caactccaga tagtcagtct ctgcgctgtg acctcattcg ctacatctgt   3180

ggggtagtcc acccttctaa tgaagtactg agttcagata tcttgccccg gtgggccatc   3240

attggttggc tcctgacaac gtgcacggtg agggcaaaag atactgggtg gtgaagggtg   3300

cctcttccat ggtgttccca tgtttccatt cttcttcctg actccagggc cacttgaccc   3360

ctaagggccc ttctttcact ctggtcttcc agagtgtctc agccttcact tccctttgtg   3420

tctctagaaa tttacttaca ctcattattt tccatctggg tttgagattg aacaggttca   3480

tctcccccat tactgccaac ccccaaaagc ctgggtttct ggagcgtccc tgcctttttc   3540

atttttgctt ccagaaacca tatacagcta ttcctcttaa ctgtttcttt ctcagattca   3600

gagcttgcat tctttagacc ctcaccacca tgcctttttg gcatcagctt tgtctacttc   3660

ccttctgtaa atgcagcgaa tctgcagtgg aggcatttcc tttcaaatgt tttcctctct   3720

gtgcctaggg tgggaaacta tccattctct ggcatctggc tgccccctga cctcttccaa   3780

cagggttcct cctcccccat ttgactgggt ccttggaatg tgctgattca gatatgacaa   3840

caggctattc ctggaggggt gggggtctct tcttcaggaa tgtgcctgga gagcccagaa   3900

agggcagcca aggggtgcta gtctgactgt tgcctcagct caggggtgat gagtggactt   3960

ctgagtccaa gcattgtccc ctatgggaat cagagatatg aactgctgga tgtatcaaga   4020

acccaggcct gccgagcacg gtggctcacg cctgtaatcc cagcactttg ggaggttgag   4080

gtgggcagat tgcttgagct caggagtttg agaccagcct gggcaacatg gcaagacccc   4140

atctctacaa aaaaatacaa aaattagcca agtgtgttgg tgtgcggctg tagtcccagg   4200

ctgaggtgag aggaccgctt gagcctggga ggtagaggtt gcagtgagct gagatcctgc   4260

cactgcactc cagcctgggt gacagagtca gaccctgtct caacaacaaa aagaaaagaa   4320

cccaggcctg gccaggcatg gtggctctca cctataatcc caatactttg ggaggctgag   4380

gtgggaggat cacttgagcc caggagttca agaccagcct gggcaacatg gcaaaaccca   4440

tctctaccaa aacaaaacaa aacaaaacat aaagccacgc atggtggtgt gctcctgtag   4500

tcccagctac caaggaggct gaggctggga ggatcacccg agcctaagag gtcaaggctg   4560

gagtaagccg tgatcatgcc actgcgctcc agcctgggtg acatggcaag accctcatct   4620

ctacaaaaaa atagaaaaat gagccaggtg aggtggtgcg tgcctgtagt cccaggctga   4680

ggtgagaggc tctctcgagc ctgggcggtg gaggttgcag tgagctgaga tcatgccact   4740

gcactacagc ctgggcaaca gagcaagacc ctgtctggaa aaaaaaaaaa aaaggttcgg   4800

ggggtacctg gcccaatccc tgtcctctgt cctcttggtt aagaccataa gaccacagag   4860

tattcactca tacacaacac aaggggggtt agcatttcac cgtgtttcac taggaactga   4920

atttcataga tgaaacagcc aagtggggcc tggaatctgt cttgggactc tgaaatggag   4980

gggggtgatt gatgaaacta gccctctgtt tctcccctct cttttccagt caaatgtcgc   5040

tgcctccaat gccaagctgg ctttgtttta tgactggctg ttctttagtc cagacaagga   5100

tagcattatg aacataggta tgtgaccaag accaggcggc tccacttccc catcccccta   5160

agcccccact gccttcctta gtgatagcag tcataaatct cagggcaccg tggagtggag   5220

gcagtttatc tgggagcagc tctgttgttc ctcatcagtt ttcccttgac ctagaaagag   5280

aattgctttg ataaggctaa gccatcactg tacctcctcc ccacagtctt caggatgcat   5340

ggtcttcagg aggggagggc atgggcaaag gaaaaggctg taccatgtcc tgcttctcct   5400

cacctattac ttcccttctc aaagctgaat gctgggaaca agaagggaaa tgagggctac   5460

aagctgtttc ggggcctgtc tgctcttggg tctgctcagt ggaaatgggg ggaatagaca   5520

tagcacttcc cagagccatt catgtatatt gacatcccat tttatggaga tagaaacaga   5580

ctgactttag cctggcgtgg tggcgcacac ctgtaattcc agctgctggg gaggttgagg   5640

catgagattc gcttgaacct gggaggcaga ggcttcagtg agctgagatc gtaccatttg   5700

cactccagcc tgggtgacag agcaagactc tgtttc                             5736


<210>  681
<211>  185
<212>  PRT
<213>  Homo sapiens

<400>  681


Met Ala Val Tyr Thr Tyr Leu Arg Leu Ile Val Asp His His Gly Thr 
1               5                   10                  15      


Ala Gln Leu Gln Ala Leu Arg Gln Lys Glu Val Asp Phe Cys Ile Ser 
            20                  25                  30          


Leu Leu Arg Glu Arg Phe Met Glu Cys Leu Met Ile Gly Arg Asp Leu 
        35                  40                  45              


Val Arg Leu Leu Gln Asn Val Ala Arg Ile Pro Glu Phe Glu Leu Leu 
    50                  55                  60                  


Trp Lys Asp Ile Ile His Asn Pro Gln Ala Leu Ser Pro Gln Phe Thr 
65                  70                  75                  80  


Gly Ile Leu Gln Leu Leu Gln Ser Arg Thr Ser Arg Lys Phe Leu Ala 
                85                  90                  95      


Cys Arg Leu Thr Pro Asp Met Glu Thr Lys Leu Leu Phe Met Thr Ser 
            100                 105                 110         


Arg Val Arg Phe Gly Gln Gln Lys Arg Tyr Gln Asp Trp Phe Gln Arg 
        115                 120                 125             


Gln Tyr Leu Ser Thr Pro Asp Ser Gln Ser Leu Arg Cys Asp Leu Ile 
    130                 135                 140                 


Arg Tyr Ile Cys Gly Val Val His Pro Ser Asn Glu Val Leu Ser Ser 
145                 150                 155                 160 


Asp Ile Leu Pro Arg Trp Ala Ile Ile Gly Trp Leu Leu Thr Thr Cys 
                165                 170                 175     


Thr Val Arg Ala Lys Asp Thr Gly Trp 
            180                 185 

<210>  682
<211>  6176
<212>  DNA
<213>  Homo sapiens

<400>  682
gccttcccac cccccgccct tccactatgg ccgcttctgt gtggtgtggg gagacgctgg     60

tcctccccgt cctcccatag cgcttattgc ctcaccctca ccccctaggg gccggatcca    120

aaggcgctgc actccccaag ccttggggca tcagccagga aggtttccta cctcctaatt    180

caggggcagg actcctcttt tccccccacg gggaaaagag gcagaaactt aggggtttcc    240

ctcctttctt agggtcagac gctcttaggg tccacttctt caggggcgga agcctctcct    300

acccttccca tagggacaca ggcctttacc ccactgtact tcggagccaa cgcctttccc    360

tcagcactgc caccccagag tcaggaccca gaggactgtg ccttcgcccc caacgcaggc    420

gcggcctttt ggagaggagg gaggagtgga gaggacaggg gcccttgctc tcccctcccc    480

aacttgttcc tcttgccccc cagtccctgg caatccagag atcccgatat ctaggactgt    540

ccatccatcc actccctgac cttttcccgg ctcctggctg cagccatgga gttgcagaag    600

ggaaaagggg cggcagcagc agcagctgct tcgggagcag cgggaggtgg aggaggagga    660

gcgggagcag gagccccagg aggggggagg ctgctacttt caaccagttt ggatgccaag    720

gatgagttag aggagagatt ggaaaggtgt atgagcattg tgacatcgat gactgctggt    780

gtctcggaga gagaagccaa tgatgccctc aatgcgtatg tgtgcaaagg cctcccccag    840

catgaagaaa tctgcctggg cctgtttact ctcatcctca ctgaacctgc ccaagcccag    900

aagtgttacc gggacttagc tctggtgagt cgtgatggca tgaatattgt cctgaataaa    960

atcaaccaga tacttatgga gaagtacctg aagctgcagg atacctgccg tactcaggta   1020

aggccagaaa gaaaagacaa gatccagctc aaagagagag gatggatctt ctctctgtca   1080

ggaacgggaa agaggaatca gggctaacac acccctatca ttgtgtgtct aaattgtaat   1140

gtgctccttt cagttgtaat tgaattagct cccttctcaa actcacagtt cctgctcttc   1200

atctgttttt ccctctttcc tttagttggt gtggttggta cgggaactgg tgaagagtgg   1260

ggttctggga gccgatggtg tttgtatgac gtttatgaag cagattgcag gtgagtttga   1320

tggcaggagc ataaagaaga aaggaggaga gcccagagac tacatagaga caatggagaa   1380

tgattaagtg ccaaagggat ggaattcttg gattgcttag actgtttcct tctgatacag   1440

acatcttctg gccacatatg ttgtagaaat aaattgattg aaaaatcatg gggggccttt   1500

taaagcagta agtcttgcct cattttcttt cctgctaaac ccagggcttg acagaatatt   1560

tggcctattt tagccagtct tcactctgag attttatagc atttcagagc aggaagaaat   1620

ggggagagaa gtgagggcaa ttaatttgtt ctcaagtccc tgtgctttca gaaacctaga   1680

catcttccct ggctccaccc ccattatctg aacgcttgct ccctaataat taagcccttt   1740

actggggcca gaatgaggga caaactatgt cacagaacag accctgacat ttaggtttta   1800

ttctcatctt ggcatcggtg acatctgtct gagctatcgc atattcaagc ggctactccc   1860

aagattgcat gtgtttgttt aaaagtgacc tgctactacc tcaccattag cccactggga   1920

cttgcttcct ctttaaaatt ttatgtaaca ctgatgctcc tgttttgatg tgtatgaacc   1980

ttaatctatg tgatatgtga ctttgtgaac attgaatttt ttaattgaga cctggggcaa   2040

ggcatagttg tagctatttt tatcctcttt cctggcactt cttccctgtt tggcacttcc   2100

agcccctgct tcttatccca agactggtat ggcattgctg tgtgttaatt ctgccccaca   2160

gagtttcata gcaagcacta aagactgtta cctggaaata agaaactctt ggcctgttgg   2220

gggcctcagt gcaggactca ggacatccag ttgctagact gcagctgttg tcagccacct   2280

gtacttctca ggctctatct gagatatcat cctttctttc caactgtggg cttcttatat   2340

ctacttctca gacgttcatt ttcaagggcc aaaatgttcc cactccaact cacaatctgt   2400

gggaaagtag cagctctggt ttctagaaaa attcagaacc ttccctttcc ttctttctgg   2460

aggcaaaggg tgaaacttta aagcctgaca gaacagaagg cagtttatct cagcagtgaa   2520

gggatggcag taatgggatg gcagtcaggg tggaccagca gaatgggtga agagatgtat   2580

tggattggct gacttgctaa tcggagctat tctttttttc cccttttgaa atcaggtgga   2640

gatgttacag ccaaaaatat ctggttggca gaaagtgttc tggatatcct gacagagcaa   2700

agggagtggg tcctgaagag cagcatcctc attgccatgg ctgtttacac gtacctccgc   2760

ctcatcgtgg accaccatgg gactgcccag ctccaggccc tgcgacagaa ggaagtagac   2820

ttctgcatct cactgcttcg ggaacggttc atggaatgtc tgatgattgg tcgggatctc   2880

gtaagactac ttcagaatgt tgctaggata ccagaatttg aactgctttg gaaagatatt   2940

atccataatc ctcaggcctt gagtcctcag ttcacaggct ggtgtgcaat ggcgtgatct   3000

cagctcactg caacctccgc ctcctgggtt caagcgattc tcccgcctca gcctcccagg   3060

tagctaggat tacaggcacc tgccatcatg cccaggtatc ctacagcttc ttcagtcaag   3120

aacatcccga aaattcctag catgtcgtct aaccccggac atggagacta aactcctctt   3180

catgacatcc cgggtgcgat ttggtcaaca aaagcgatac caagattggt tccagcgcca   3240

gtacctgtca actccagata gtcagtctct gcgctgtgac ctcattcgct acatctgtgg   3300

ggtagtccac ccttctaatg aagtactgag ttcagatatc ttgccccggt gggccatcat   3360

tggttggctc ctgacaacgt gcacgtcaaa tgtcgctgcc tccaatgcca agctggcttt   3420

gttttatgac tggctgttct ttagtccaga caaggatagc attatgaaca tagaaccagc   3480

catcctggtc atgcaccact ccatgaagcc ccacccagcc atcactgcca cactcctgga   3540

cttcatgtgc cgcatcattc ccaacttcta tccaccattg gagggccacg tgcggcaggg   3600

tgtcttttcc tccctcaacc acattgtgga gaaacgggtc ttggcacacc tagctcccct   3660

gtttgacaac cctaagttgg ataaggagct gcgggcaatg ctgagagaga agtttcctga   3720

gttctgcagc tcaccctccc cacctgtgga agtcaaaatt gaggagccag tttccatgga   3780

gatggacaac catatgtcgg ataaggatga gagttgctat gacaatgcag aggcagcctt   3840

cagtgacgat gaagaggatc tcaacagcaa aggaaagaag agggagtttc gcttccaccc   3900

tatcaaggag acagttgtgg aggagccagt tgatatcacc ccttaccttg accagttgga   3960

tgagtccctg agggacaaag tactccagct acagaagggg agtgatacgg aggcccagtg   4020

tgaggtcatg caggaaattg tggaccaggt cctggaggaa gactttgact cggagcagct   4080

gtctgtcctt gcttcctgcc tacaggagct cttcaaggcc cactttcgag gggaggtcct   4140

gcctgaggag attactgagg agtccctgga ggagtctgta ggaaagcctc tgtacctaat   4200

atttaggaac ctatgtcaga tgcaggaaga caacagcagc ttctctctac ttctagacct   4260

tctctccgag ctatatcaga agcagcccaa gattggctac cacctgctct actacctgag   4320

ggccagcaaa gccgccgcag ggaagatgaa cctgtacgag tcatttgccc aggctaccca   4380

gctgggcgat ctgcacacct gcctgatgat ggacatgaag gcctgccagg aggacgatgt   4440

gcggctcctg tgccacctca cgccctccat ctacacagag tttccagatg aaaccttgag   4500

gagcggagag ctgctgaaca tgatcgtggc tgttattgac tctgcacagc tccaggagct   4560

ggtctgccac gtgatgatgg gtaacctggt tatgtttcga aaagactcag ttctcaacat   4620

actcattcag agcctagact gggagacctt tgagcagtat tgtgcctggc agctctttct   4680

ggcccacaat attcccctgg agaccataat ccccatcctg cagcacctca aatacaagga   4740

gcacccagag gccctgtcct gcctactgct tcaactccga agagaaaagc ccagcgagga   4800

gatggtgaag atggtgctga gccggccctg ccatcctgac gaccagttca ccaccagcat   4860

cctgcggcac tggtgcatga aacatgacga gctgctggcc gagcacatca agtccctgct   4920

catcaagaac aacagcctgc ctcgcaagag acagagcctg aggagctcta gcagcaagct   4980

ggcccagctg actctggagc agatcctgga gcacttggac aatctgcggc tcaacctgac   5040

caacaccaag cagaactttt ttagccagac gccaattctc caggcgctgc agcatgtcca   5100

agcgagctgt gacgaagccc acaagatgaa attcagtgat ctcttctccc tggcggagga   5160

atatgaggac tcttccacca agccacccaa gagccggcga aaagcagctc tgtccagccc   5220

tcgaagtcga aagaatgcca cacagccccc caatgccgaa gaagagtcgg gctccagcag   5280

tgcttcagaa gaggaagaca cgaaaccgaa gcctaccaag cggaaacgaa aagggtcctc   5340

tgcagtgggc tctgacagtg actgaggccc tgcattcccc atcccacccc cggctggact   5400

gccctctcct tcttggtgat tcaaaggtta atagaggctg aggagattgc aggggaaaca   5460

cccttgctgc atccccaagc tcccccggtg gaaggaggag ctttctcctc tggctgagtt   5520

tgagaagctg ccatgcagcc cctagcccct tccctcctcc tggggcctcc agcccctcac   5580

actgctgttc ccagtgatat ttgggatctg actgaagcca gaggctctgt aaaatcagac   5640

catagtggaa gtcctcagcc ccctggcccc ttccgcaatc tcctccccca gtctcccaaa   5700

gagccatttc aacagagaag ggaaatgaca aaggggcagc tggccagata agctaggatg   5760

agagcagaga ctcagtgtgt gggtgtccct tcctgcttcc ccttcaggtc ttggtttgtt   5820

ctgaagggac gttttatagt cactatccac atgccagtgt gaaatgggca tctatgacgt   5880

ggtcagggtg tccattccta atcatggggc agatgccaca agcattcaga aaggagtctg   5940

aaagggtggc cacagcccca cgtggtgtgc cctggaggct taggttggtc tgaggttggc   6000

acctcaatct acaccagagc ccagggagtc ccagaggcaa gtttcacaga attgtcaaat   6060

gatcccattt ccttgagtct gttttttttt ttgttttttt ttgttttttt tttggcagag   6120

ataatcgtgt cttaaaagtt gtttttaaat gacaataaaa caagccagaa tgtctt       6176


<210>  683
<211>  734
<212>  PRT
<213>  Homo sapiens

<400>  683


Met Glu Thr Lys Leu Leu Phe Met Thr Ser Arg Val Arg Phe Gly Gln 
1               5                   10                  15      


Gln Lys Arg Tyr Gln Asp Trp Phe Gln Arg Gln Tyr Leu Ser Thr Pro 
            20                  25                  30          


Asp Ser Gln Ser Leu Arg Cys Asp Leu Ile Arg Tyr Ile Cys Gly Val 
        35                  40                  45              


Val His Pro Ser Asn Glu Val Leu Ser Ser Asp Ile Leu Pro Arg Trp 
    50                  55                  60                  


Ala Ile Ile Gly Trp Leu Leu Thr Thr Cys Thr Ser Asn Val Ala Ala 
65                  70                  75                  80  


Ser Asn Ala Lys Leu Ala Leu Phe Tyr Asp Trp Leu Phe Phe Ser Pro 
                85                  90                  95      


Asp Lys Asp Ser Ile Met Asn Ile Glu Pro Ala Ile Leu Val Met His 
            100                 105                 110         


His Ser Met Lys Pro His Pro Ala Ile Thr Ala Thr Leu Leu Asp Phe 
        115                 120                 125             


Met Cys Arg Ile Ile Pro Asn Phe Tyr Pro Pro Leu Glu Gly His Val 
    130                 135                 140                 


Arg Gln Gly Val Phe Ser Ser Leu Asn His Ile Val Glu Lys Arg Val 
145                 150                 155                 160 


Leu Ala His Leu Ala Pro Leu Phe Asp Asn Pro Lys Leu Asp Lys Glu 
                165                 170                 175     


Leu Arg Ala Met Leu Arg Glu Lys Phe Pro Glu Phe Cys Ser Ser Pro 
            180                 185                 190         


Ser Pro Pro Val Glu Val Lys Ile Glu Glu Pro Val Ser Met Glu Met 
        195                 200                 205             


Asp Asn His Met Ser Asp Lys Asp Glu Ser Cys Tyr Asp Asn Ala Glu 
    210                 215                 220                 


Ala Ala Phe Ser Asp Asp Glu Glu Asp Leu Asn Ser Lys Gly Lys Lys 
225                 230                 235                 240 


Arg Glu Phe Arg Phe His Pro Ile Lys Glu Thr Val Val Glu Glu Pro 
                245                 250                 255     


Val Asp Ile Thr Pro Tyr Leu Asp Gln Leu Asp Glu Ser Leu Arg Asp 
            260                 265                 270         


Lys Val Leu Gln Leu Gln Lys Gly Ser Asp Thr Glu Ala Gln Cys Glu 
        275                 280                 285             


Val Met Gln Glu Ile Val Asp Gln Val Leu Glu Glu Asp Phe Asp Ser 
    290                 295                 300                 


Glu Gln Leu Ser Val Leu Ala Ser Cys Leu Gln Glu Leu Phe Lys Ala 
305                 310                 315                 320 


His Phe Arg Gly Glu Val Leu Pro Glu Glu Ile Thr Glu Glu Ser Leu 
                325                 330                 335     


Glu Glu Ser Val Gly Lys Pro Leu Tyr Leu Ile Phe Arg Asn Leu Cys 
            340                 345                 350         


Gln Met Gln Glu Asp Asn Ser Ser Phe Ser Leu Leu Leu Asp Leu Leu 
        355                 360                 365             


Ser Glu Leu Tyr Gln Lys Gln Pro Lys Ile Gly Tyr His Leu Leu Tyr 
    370                 375                 380                 


Tyr Leu Arg Ala Ser Lys Ala Ala Ala Gly Lys Met Asn Leu Tyr Glu 
385                 390                 395                 400 


Ser Phe Ala Gln Ala Thr Gln Leu Gly Asp Leu His Thr Cys Leu Met 
                405                 410                 415     


Met Asp Met Lys Ala Cys Gln Glu Asp Asp Val Arg Leu Leu Cys His 
            420                 425                 430         


Leu Thr Pro Ser Ile Tyr Thr Glu Phe Pro Asp Glu Thr Leu Arg Ser 
        435                 440                 445             


Gly Glu Leu Leu Asn Met Ile Val Ala Val Ile Asp Ser Ala Gln Leu 
    450                 455                 460                 


Gln Glu Leu Val Cys His Val Met Met Gly Asn Leu Val Met Phe Arg 
465                 470                 475                 480 


Lys Asp Ser Val Leu Asn Ile Leu Ile Gln Ser Leu Asp Trp Glu Thr 
                485                 490                 495     


Phe Glu Gln Tyr Cys Ala Trp Gln Leu Phe Leu Ala His Asn Ile Pro 
            500                 505                 510         


Leu Glu Thr Ile Ile Pro Ile Leu Gln His Leu Lys Tyr Lys Glu His 
        515                 520                 525             


Pro Glu Ala Leu Ser Cys Leu Leu Leu Gln Leu Arg Arg Glu Lys Pro 
    530                 535                 540                 


Ser Glu Glu Met Val Lys Met Val Leu Ser Arg Pro Cys His Pro Asp 
545                 550                 555                 560 


Asp Gln Phe Thr Thr Ser Ile Leu Arg His Trp Cys Met Lys His Asp 
                565                 570                 575     


Glu Leu Leu Ala Glu His Ile Lys Ser Leu Leu Ile Lys Asn Asn Ser 
            580                 585                 590         


Leu Pro Arg Lys Arg Gln Ser Leu Arg Ser Ser Ser Ser Lys Leu Ala 
        595                 600                 605             


Gln Leu Thr Leu Glu Gln Ile Leu Glu His Leu Asp Asn Leu Arg Leu 
    610                 615                 620                 


Asn Leu Thr Asn Thr Lys Gln Asn Phe Phe Ser Gln Thr Pro Ile Leu 
625                 630                 635                 640 


Gln Ala Leu Gln His Val Gln Ala Ser Cys Asp Glu Ala His Lys Met 
                645                 650                 655     


Lys Phe Ser Asp Leu Phe Ser Leu Ala Glu Glu Tyr Glu Asp Ser Ser 
            660                 665                 670         


Thr Lys Pro Pro Lys Ser Arg Arg Lys Ala Ala Leu Ser Ser Pro Arg 
        675                 680                 685             


Ser Arg Lys Asn Ala Thr Gln Pro Pro Asn Ala Glu Glu Glu Ser Gly 
    690                 695                 700                 


Ser Ser Ser Ala Ser Glu Glu Glu Asp Thr Lys Pro Lys Pro Thr Lys 
705                 710                 715                 720 


Arg Lys Arg Lys Gly Ser Ser Ala Val Gly Ser Asp Ser Asp 
                725                 730                 

<210>  684
<211>  6058
<212>  DNA
<213>  Homo sapiens

<400>  684
gccttcccac cccccgccct tccactatgg ccgcttctgt gtggtgtggg gagacgctgg     60

tcctccccgt cctcccatag cgcttattgc ctcaccctca ccccctaggg gccggatcca    120

aaggcgctgc actccccaag ccttggggca tcagccagga aggtttccta cctcctaatt    180

caggggcagg actcctcttt tccccccacg gggaaaagag gcagaaactt aggggtttcc    240

ctcctttctt agggtcagac gctcttaggg tccacttctt caggggcgga agcctctcct    300

acccttccca tagggacaca ggcctttacc ccactgtact tcggagccaa cgcctttccc    360

tcagcactgc caccccagag tcaggaccca gaggactgtg ccttcgcccc caacgcaggc    420

gcggcctttt ggagaggagg gaggagtgga gaggacaggg gcccttgctc tcccctcccc    480

aacttgttcc tcttgccccc cagtccctgg caatccagag atcccgatat ctaggactgt    540

ccatccatcc actccctgac cttttcccgg ctcctggctg cagccatgga gttgcagaag    600

ggaaaagggg cggcagcagc agcagctgct tcgggagcag cgggaggtgg aggaggagga    660

gcgggagcag gagccccagg aggggggagg ctgctacttt caaccagttt ggatgccaag    720

gatgagttag aggagagatt ggaaaggtgt atgagcattg tgacatcgat gactgctggt    780

gtctcggaga gagaagccaa tgatgccctc aatgcgtatg tgtgcaaagg cctcccccag    840

catgaagaaa tctgcctggg cctgtttact ctcatcctca ctgaacctgc ccaagcccag    900

aagtgttacc gggacttagc tctggtgagt cgtgatggca tgaatattgt cctgaataaa    960

atcaaccaga tacttatgga gaagtacctg aagctgcagg atacctgccg tactcaggta   1020

aggccagaaa gaaaagacaa gatccagctc aaagagagag gatggatctt ctctctgtca   1080

ggaacgggaa agaggaatca gggctaacac acccctatca ttgtgtgtct aaattgtaat   1140

gtgctccttt cagttgtaat tgaattagct cccttctcaa actcacagtt cctgctcttc   1200

atctgttttt ccctctttcc tttagttggt gtggttggta cgggaactgg tgaagagtgg   1260

ggttctggga gccgatggtg tttgtatgac gtttatgaag cagattgcag gtgagtttga   1320

tggcaggagc ataaagaaga aaggaggaga gcccagagac tacatagaga caatggagaa   1380

tgattaagtg ccaaagggat ggaattcttg gattgcttag actgtttcct tctgatacag   1440

acatcttctg gccacatatg ttgtagaaat aaattgattg aaaaatcatg gggggccttt   1500

taaagcagta agtcttgcct cattttcttt cctgctaaac ccagggcttg acagaatatt   1560

tggcctattt tagccagtct tcactctgag attttatagc atttcagagc aggaagaaat   1620

ggggagagaa gtgagggcaa ttaatttgtt ctcaagtccc tgtgctttca gaaacctaga   1680

catcttccct ggctccaccc ccattatctg aacgcttgct ccctaataat taagcccttt   1740

actggggcca gaatgaggga caaactatgt cacagaacag accctgacat ttaggtttta   1800

ttctcatctt ggcatcggtg acatctgtct gagctatcgc atattcaagc ggctactccc   1860

aagattgcat gtgtttgttt aaaagtgacc tgctactacc tcaccattag cccactggga   1920

cttgcttcct ctttaaaatt ttatgtaaca ctgatgctcc tgttttgatg tgtatgaacc   1980

ttaatctatg tgatatgtga ctttgtgaac attgaatttt ttaattgaga cctggggcaa   2040

ggcatagttg tagctatttt tatcctcttt cctggcactt cttccctgtt tggcacttcc   2100

agcccctgct tcttatccca agactggtat ggcattgctg tgtgttaatt ctgccccaca   2160

gagtttcata gcaagcacta aagactgtta cctggaaata agaaactctt ggcctgttgg   2220

gggcctcagt gcaggactca ggacatccag ttgctagact gcagctgttg tcagccacct   2280

gtacttctca ggctctatct gagatatcat cctttctttc caactgtggg cttcttatat   2340

ctacttctca gacgttcatt ttcaagggcc aaaatgttcc cactccaact cacaatctgt   2400

gggaaagtag cagctctggt ttctagaaaa attcagaacc ttccctttcc ttctttctgg   2460

aggcaaaggg tgaaacttta aagcctgaca gaacagaagg cagtttatct cagcagtgaa   2520

gggatggcag taatgggatg gcagtcaggg tggaccagca gaatgggtga agagatgtat   2580

tggattggct gacttgctaa tcggagctat tctttttttc cccttttgaa atcaggtgga   2640

gatgttacag ccaaaaatat ctggttggca gaaagtgttc tggatatcct gacagagcaa   2700

agggagtggg tcctgaagag cagcatcctc attgccatgg ctgtttacac gtacctccgc   2760

ctcatcgtgg accaccatgg gactgcccag ctccaggccc tgcgacagaa ggaagtagac   2820

ttctgcatct cactgcttcg ggaacggttc atggaatgtc tgatgattgg tcgggatctc   2880

gtaagactac ttcagaatgt tgctaggata ccagaatttg aactgctttg gaaagatatt   2940

atccataatc ctcaggcctt gagtcctcag ttcacaggta tcctacagct tcttcagtca   3000

agaacatccc gaaaattcct agcatgtcgt ctaaccccgg acatggagac taaactcctc   3060

ttcatgacat cccgggtgcg atttggtcaa caaaagcgat accaagattg gttccagcgc   3120

cagtacctgt caactccaga tagtcagtct ctgcgctgtg acctcattcg ctacatctgt   3180

ggggtagtcc acccttctaa tgaagtactg agttcagata tcttgccccg gtgggccatc   3240

attggttggc tcctgacaac gtgcacgtca aatgtcgctg cctccaatgc caagctggct   3300

ttgttttatg actggctgtt ctttagtcca gacaaggata gcattatgaa catagaacca   3360

gccatcctgg tcatgcacca ctccatgaag ccccacccag ccatcactgc cacactcctg   3420

gacttcatgt gccgcatcat tcccaacttc tatccaccat tggagggcca cgtgcggcag   3480

ggtgtctttt cctccctcaa ccacattgtg gagaaacggg tcttggcaca cctagctccc   3540

ctgtttgaca accctaagtt ggataaggag ctgcgggcaa tgctgagaga gaagtttcct   3600

gagttctgca gctcaccctc cccacctgtg gaagtcaaaa ttgaggagcc agtttccatg   3660

gagatggaca accatatgtc ggataaggat gagagttgct atgacaatgc agaggcagcc   3720

ttcagtgacg atgaagagga tctcaacagc aaaggaaaga agagggagtt tcgcttccac   3780

cctatcaagg agacagttgt ggaggagcca gttgatatca ccccttacct tgaccagttg   3840

gatgagtccc tgagggacaa agtactccag ctacagaagg ggagtgatac ggaggcccag   3900

tgtgaggtca tgcaggaaat tgtggaccag gtcctggagg aagactttga ctcggagcag   3960

ctgtctgtcc ttgcttcctg cctacaggag ctcttcaagg cccactttcg aggggaggtc   4020

ctgcctgagg agattactga ggagtccctg gaggagtctg taggaaagcc tctgtaccta   4080

atatttagga acctatgtca gatgcaggaa gacaacagca gcttctctct acttctagac   4140

cttctctccg agctatatca gaagcagccc aagattggct accacctgct ctactacctg   4200

agggccagca aagccgccgc agggaagatg aacctgtacg agtcatttgc ccaggctacc   4260

cagctgggcg atctgcacac ctgcctgatg atggacatga aggcctgcca ggaggacgat   4320

gtgcggctcc tgtgccacct cacgccctcc atctacacag agtttccaga tgaaaccttg   4380

aggagcggag agctgctgaa catgatcgtg gctgttattg actctgcaca gctccaggag   4440

ctggtctgcc acgtgatgat gggtaacctg gttatgtttc gaaaagactc agttctcaac   4500

atactcattc agagcctaga ctgggagacc tttgagcagt attgtgcctg gcagctcttt   4560

ctggcccaca atattcccct ggagaccata atccccatcc tgcagcacct caaatacaag   4620

gagcacccag aggccctgtc ctgcctactg cttcaactcc gaagagaaaa gcccagcgag   4680

gagatggtga agatggtgct gagccggccc tgccatcctg acgaccagtt caccaccagc   4740

atcctgcggc actggtgcat gaaacatgac gagctgctgg ccgagcacat caagtccctg   4800

ctcatcaaga acaacagcct gcctcgcaag agacagagcc tgaggagctc tagcagcaag   4860

ctggcccagc tgactctgga gcagatcctg gagcacttgg acaatctgcg gctcaacctg   4920

accaacacca agcagaactt ttttagccag acgccaattc tccaggcgct gcagcatgtc   4980

caagcgagct gtgacgaagc ccacaagatg aaattcagtg atctcttctc cctggcggag   5040

gaatatgagg actcttccac caagccaccc aagagccggc gaaaagcagc tctgtccagc   5100

cctcgaagtc gaaagaatgc cacacagccc cccaatgccg aagaagagtc gggctccagc   5160

agtgcttcag aagaggaaga cacgaaaccg aagcctacca agcggaaacg aaaagggtcc   5220

tctgcagtgg gctctgacag tgactgaggc cctgcattcc ccatcccacc cccggctgga   5280

ctgccctctc cttcttggtg attcaaaggt taatagaggc tgaggagatt gcaggggaaa   5340

cacccttgct gcatccccaa gctcccccgg tggaaggagg agctttctcc tctggctgag   5400

tttgagaagc tgccatgcag cccctagccc cttccctcct cctggggcct ccagcccctc   5460

acactgctgt tcccagtgat atttgggatc tgactgaagc cagaggctct gtaaaatcag   5520

accatagtgg aagtcctcag ccccctggcc ccttccgcaa tctcctcccc cagtctccca   5580

aagagccatt tcaacagaga agggaaatga caaaggggca gctggccaga taagctagga   5640

tgagagcaga gactcagtgt gtgggtgtcc cttcctgctt ccccttcagg tcttggtttg   5700

ttctgaaggg acgttttata gtcactatcc acatgccagt gtgaaatggg catctatgac   5760

gtggtcaggg tgtccattcc taatcatggg gcagatgcca caagcattca gaaaggagtc   5820

tgaaagggtg gccacagccc cacgtggtgt gccctggagg cttaggttgg tctgaggttg   5880

gcacctcaat ctacaccaga gcccagggag tcccagaggc aagtttcaca gaattgtcaa   5940

atgatcccat ttccttgagt ctgttttttt ttttgttttt ttttgttttt tttttggcag   6000

agataatcgt gtcttaaaag ttgtttttaa atgacaataa aacaagccag aatgtctt     6058


<210>  685
<211>  836
<212>  PRT
<213>  Homo sapiens

<400>  685


Met Ala Val Tyr Thr Tyr Leu Arg Leu Ile Val Asp His His Gly Thr 
1               5                   10                  15      


Ala Gln Leu Gln Ala Leu Arg Gln Lys Glu Val Asp Phe Cys Ile Ser 
            20                  25                  30          


Leu Leu Arg Glu Arg Phe Met Glu Cys Leu Met Ile Gly Arg Asp Leu 
        35                  40                  45              


Val Arg Leu Leu Gln Asn Val Ala Arg Ile Pro Glu Phe Glu Leu Leu 
    50                  55                  60                  


Trp Lys Asp Ile Ile His Asn Pro Gln Ala Leu Ser Pro Gln Phe Thr 
65                  70                  75                  80  


Gly Ile Leu Gln Leu Leu Gln Ser Arg Thr Ser Arg Lys Phe Leu Ala 
                85                  90                  95      


Cys Arg Leu Thr Pro Asp Met Glu Thr Lys Leu Leu Phe Met Thr Ser 
            100                 105                 110         


Arg Val Arg Phe Gly Gln Gln Lys Arg Tyr Gln Asp Trp Phe Gln Arg 
        115                 120                 125             


Gln Tyr Leu Ser Thr Pro Asp Ser Gln Ser Leu Arg Cys Asp Leu Ile 
    130                 135                 140                 


Arg Tyr Ile Cys Gly Val Val His Pro Ser Asn Glu Val Leu Ser Ser 
145                 150                 155                 160 


Asp Ile Leu Pro Arg Trp Ala Ile Ile Gly Trp Leu Leu Thr Thr Cys 
                165                 170                 175     


Thr Ser Asn Val Ala Ala Ser Asn Ala Lys Leu Ala Leu Phe Tyr Asp 
            180                 185                 190         


Trp Leu Phe Phe Ser Pro Asp Lys Asp Ser Ile Met Asn Ile Glu Pro 
        195                 200                 205             


Ala Ile Leu Val Met His His Ser Met Lys Pro His Pro Ala Ile Thr 
    210                 215                 220                 


Ala Thr Leu Leu Asp Phe Met Cys Arg Ile Ile Pro Asn Phe Tyr Pro 
225                 230                 235                 240 


Pro Leu Glu Gly His Val Arg Gln Gly Val Phe Ser Ser Leu Asn His 
                245                 250                 255     


Ile Val Glu Lys Arg Val Leu Ala His Leu Ala Pro Leu Phe Asp Asn 
            260                 265                 270         


Pro Lys Leu Asp Lys Glu Leu Arg Ala Met Leu Arg Glu Lys Phe Pro 
        275                 280                 285             


Glu Phe Cys Ser Ser Pro Ser Pro Pro Val Glu Val Lys Ile Glu Glu 
    290                 295                 300                 


Pro Val Ser Met Glu Met Asp Asn His Met Ser Asp Lys Asp Glu Ser 
305                 310                 315                 320 


Cys Tyr Asp Asn Ala Glu Ala Ala Phe Ser Asp Asp Glu Glu Asp Leu 
                325                 330                 335     


Asn Ser Lys Gly Lys Lys Arg Glu Phe Arg Phe His Pro Ile Lys Glu 
            340                 345                 350         


Thr Val Val Glu Glu Pro Val Asp Ile Thr Pro Tyr Leu Asp Gln Leu 
        355                 360                 365             


Asp Glu Ser Leu Arg Asp Lys Val Leu Gln Leu Gln Lys Gly Ser Asp 
    370                 375                 380                 


Thr Glu Ala Gln Cys Glu Val Met Gln Glu Ile Val Asp Gln Val Leu 
385                 390                 395                 400 


Glu Glu Asp Phe Asp Ser Glu Gln Leu Ser Val Leu Ala Ser Cys Leu 
                405                 410                 415     


Gln Glu Leu Phe Lys Ala His Phe Arg Gly Glu Val Leu Pro Glu Glu 
            420                 425                 430         


Ile Thr Glu Glu Ser Leu Glu Glu Ser Val Gly Lys Pro Leu Tyr Leu 
        435                 440                 445             


Ile Phe Arg Asn Leu Cys Gln Met Gln Glu Asp Asn Ser Ser Phe Ser 
    450                 455                 460                 


Leu Leu Leu Asp Leu Leu Ser Glu Leu Tyr Gln Lys Gln Pro Lys Ile 
465                 470                 475                 480 


Gly Tyr His Leu Leu Tyr Tyr Leu Arg Ala Ser Lys Ala Ala Ala Gly 
                485                 490                 495     


Lys Met Asn Leu Tyr Glu Ser Phe Ala Gln Ala Thr Gln Leu Gly Asp 
            500                 505                 510         


Leu His Thr Cys Leu Met Met Asp Met Lys Ala Cys Gln Glu Asp Asp 
        515                 520                 525             


Val Arg Leu Leu Cys His Leu Thr Pro Ser Ile Tyr Thr Glu Phe Pro 
    530                 535                 540                 


Asp Glu Thr Leu Arg Ser Gly Glu Leu Leu Asn Met Ile Val Ala Val 
545                 550                 555                 560 


Ile Asp Ser Ala Gln Leu Gln Glu Leu Val Cys His Val Met Met Gly 
                565                 570                 575     


Asn Leu Val Met Phe Arg Lys Asp Ser Val Leu Asn Ile Leu Ile Gln 
            580                 585                 590         


Ser Leu Asp Trp Glu Thr Phe Glu Gln Tyr Cys Ala Trp Gln Leu Phe 
        595                 600                 605             


Leu Ala His Asn Ile Pro Leu Glu Thr Ile Ile Pro Ile Leu Gln His 
    610                 615                 620                 


Leu Lys Tyr Lys Glu His Pro Glu Ala Leu Ser Cys Leu Leu Leu Gln 
625                 630                 635                 640 


Leu Arg Arg Glu Lys Pro Ser Glu Glu Met Val Lys Met Val Leu Ser 
                645                 650                 655     


Arg Pro Cys His Pro Asp Asp Gln Phe Thr Thr Ser Ile Leu Arg His 
            660                 665                 670         


Trp Cys Met Lys His Asp Glu Leu Leu Ala Glu His Ile Lys Ser Leu 
        675                 680                 685             


Leu Ile Lys Asn Asn Ser Leu Pro Arg Lys Arg Gln Ser Leu Arg Ser 
    690                 695                 700                 


Ser Ser Ser Lys Leu Ala Gln Leu Thr Leu Glu Gln Ile Leu Glu His 
705                 710                 715                 720 


Leu Asp Asn Leu Arg Leu Asn Leu Thr Asn Thr Lys Gln Asn Phe Phe 
                725                 730                 735     


Ser Gln Thr Pro Ile Leu Gln Ala Leu Gln His Val Gln Ala Ser Cys 
            740                 745                 750         


Asp Glu Ala His Lys Met Lys Phe Ser Asp Leu Phe Ser Leu Ala Glu 
        755                 760                 765             


Glu Tyr Glu Asp Ser Ser Thr Lys Pro Pro Lys Ser Arg Arg Lys Ala 
    770                 775                 780                 


Ala Leu Ser Ser Pro Arg Ser Arg Lys Asn Ala Thr Gln Pro Pro Asn 
785                 790                 795                 800 


Ala Glu Glu Glu Ser Gly Ser Ser Ser Ala Ser Glu Glu Glu Asp Thr 
                805                 810                 815     


Lys Pro Lys Pro Thr Lys Arg Lys Arg Lys Gly Ser Ser Ala Val Gly 
            820                 825                 830         


Ser Asp Ser Asp 
        835     

<210>  686
<211>  4525
<212>  DNA
<213>  Homo sapiens

<400>  686
gccttcccac cccccgccct tccactatgg ccgcttctgt gtggtgtggg gagacgctgg     60

tcctccccgt cctcccatag cgcttattgc ctcaccctca ccccctaggg gccggatcca    120

aaggcgctgc actccccaag ccttggggca tcagccagga aggtttccta cctcctaatt    180

caggggcagg actcctcttt tccccccacg gggaaaagag gcagaaactt aggggtttcc    240

ctcctttctt agggtcagac gctcttaggg tccacttctt caggggcgga agcctctcct    300

acccttccca tagggacaca ggcctttacc ccactgtact tcggagccaa cgcctttccc    360

tcagcactgc caccccagag tcaggaccca gaggactgtg ccttcgcccc caacgcaggc    420

gcggcctttt ggagaggagg gaggagtgga gaggacaggg gcccttgctc tcccctcccc    480

aacttgttcc tcttgccccc cagtccctgg caatccagag atcccgatat ctaggactgt    540

ccatccatcc actccctgac cttttcccgg ctcctggctg cagccatgga gttgcagaag    600

ggaaaagggg cggcagcagc agcagctgct tcgggagcag cgggaggtgg aggaggagga    660

gcgggagcag gagccccagg aggggggagg ctgctacttt caaccagttt ggatgccaag    720

gatgagttag aggagagatt ggaaaggtgt atgagcattg tgacatcgat gactgctggt    780

gtctcggaga gagaagccaa tgatgccctc aatgcgtatg tgtgcaaagg cctcccccag    840

catgaagaaa tctgcctggg cctgtttact ctcatcctca ctgaacctgc ccaagcccag    900

aagtgttacc gggacttagc tctggtgagt cgtgatggca tgaatattgt cctgaataaa    960

atcaaccaga tacttatgga gaagtacctg aagctgcagg atacctgccg tactcagttg   1020

gtgtggttgg tacgggaact ggtgaagagt ggggttctgg gagccgatgg tgtttgtatg   1080

acgtttatga agcagattgc aggtggagat gttacagcca aaaatatctg gttggcagaa   1140

agtgttctgg atatcctgac agagcaaagg gagtgggtcc tgaagagcag catcctcatt   1200

gccatggctg tttacacgta cctccgcctc atcgtggacc accatgggac tgcccagctc   1260

caggccctgc gacagaagga agtagacttc tgcatctcac tgcttcggga acggttcatg   1320

gaatgtctga tgattggtcg ggatctcgta agactacttc agaatgttgc taggatacca   1380

gaatttgaac tgctttggaa agatattatc cataatcctc aggccttgag tcctcagttc   1440

acaggtatcc tacagcttct tcagtcaaga acatcccgaa aattcctagc atgtcgtcta   1500

accccggaca tggagactaa actcctcttc atgacatccc gggtgcgatt tggtcaacaa   1560

aagcgatacc aagattggtt ccagcgccag tacctgtcaa ctccagatag tcagtctctg   1620

cgctgtgacc tcattcgcta catctgtggg gtagtccacc cttctaatga agtactgagt   1680

tcagatatct tgccccggtg ggccatcatt ggttggctcc tgacaacgtg cacgtcaaat   1740

gtcgctgcct ccaatgccaa gctggctttg ttttatgact ggctgttctt tagtccagac   1800

aaggatagca ttatgaacat agaaccagcc atcctggtca tgcaccactc catgaagccc   1860

cacccagcca tcactgccac actcctggac ttcatgtgcc gcatcattcc caacttctat   1920

ccaccattgg agggccacgt gcggcagggt gtcttttcct ccctcaacca cattgtggag   1980

aaacgggtct tggcacacct agctcccctg tttgacaacc ctaagttgga taaggagctg   2040

cgggcaatgc tgagagagaa gtttcctgag ttctgcagct caccctcccc acctgtggaa   2100

gtcaaaattg aggagccagt ttccatggag atggacaacc atatgtcgga taaggatgag   2160

agttgctatg acaatgcaga ggcagccttc agtgacgatg aagaggatct caacagcaaa   2220

ggaaagaaga gggagtttcg cttccaccct atcaaggaga cagttgtgga ggagccagtt   2280

gatatcaccc cttaccttga ccagttggat gagtccctga gggacaaagt actccagcta   2340

cagaagggga gtgatacgga ggcccagtgt gaggtcatgc aggaaattgt ggaccaggtc   2400

ctggaggaag actttgactc ggagcagctg tctgtccttg cttcctgcct acaggagctc   2460

ttcaaggccc actttcgagg ggaggtcctg cctgaggaga ttactgagga gtccctggag   2520

gagtctgtag gaaagcctct gtacctaata tttaggaacc tatgtcagat gcaggaagac   2580

aacagcagct tctctctact tctagacctt ctctccgagc tatatcagaa gcagcccaag   2640

attggctacc acctgctcta ctacctgagg gccagcaaag ccgccgcagg gaagatgaac   2700

ctgtacgagt catttgccca ggctacccag ctgggcgatc tgcacacctg cctgatgatg   2760

gacatgaagg cctgccagga ggacgatgtg cggctcctgt gccacctcac gccctccatc   2820

tacacagagt ttccagatga aaccttgagg agcggagagc tgctgaacat gatcgtggct   2880

gttattgact ctgcacagct ccaggagctg gtctgccacg tgatgatggg taacctggtt   2940

atgtttcgaa aagactcagt tctcaacata ctcattcaga gcctagactg ggagaccttt   3000

gagcagtatt gtgcctggca gctctttctg gcccacaata ttcccctgga gaccataatc   3060

cccatcctgc agcacctcaa atacaaggag cacccagagg ccctgtcctg cctactgctt   3120

caactccgaa gagaaaagcc cagcgaggag atggtgaaga tggtgctgag ccggccctgc   3180

catcctgacg accagttcac caccagcatc ctgcggcact ggtgcatgaa acatgacgag   3240

ctgctggccg agcacatcaa gtccctgctc atcaagaaca acagcctgcc tcgcaagaga   3300

cagagcctga ggagctctag cagcaagctg gcccagctga ctctggagca gatcctggag   3360

cacttggaca atctgcggct caacctgacc aacaccaagc agaacttttt tagccagacg   3420

ccaattctcc aggcgctgca gcatgtccaa gcgagctgtg acgaagccca caagatgaaa   3480

ttcagtgatc tcttctccct ggcggaggaa tatgaggact cttccaccaa gccacccaag   3540

agccggcgaa aagcagctct gtccagccct cgaagtcgaa agaatgccac acagcccccc   3600

aatgccgaag aagagtcggg ctccagcagt gcttcagaag aggaagacac gaaaccgaag   3660

cctaccaagc ggaaacgaaa agggtcctct gcagtgggct ctgacagtga ctgaggccct   3720

gcattcccca tcccaccccc ggctggactg ccctctcctt cttggtgatt caaaggttaa   3780

tagaggctga ggagattgca ggggaaacac ccttgctgca tccccaagct cccccggtgg   3840

aaggaggagc tttctcctct ggctgagttt gagaagctgc catgcagccc ctagcccctt   3900

ccctcctcct ggggcctcca gcccctcaca ctgctgttcc cagtgatatt tgggatctga   3960

ctgaagccag aggctctgta aaatcagacc atagtggaag tcctcagccc cctggcccct   4020

tccgcaatct cctcccccag tctcccaaag agccatttca acagagaagg gaaatgacaa   4080

aggggcagct ggccagataa gctaggatga gagcagagac tcagtgtgtg ggtgtccctt   4140

cctgcttccc cttcaggtct tggtttgttc tgaagggacg ttttatagtc actatccaca   4200

tgccagtgtg aaatgggcat ctatgacgtg gtcagggtgt ccattcctaa tcatggggca   4260

gatgccacaa gcattcagaa aggagtctga aagggtggcc acagccccac gtggtgtgcc   4320

ctggaggctt aggttggtct gaggttggca cctcaatcta caccagagcc cagggagtcc   4380

cagaggcaag tttcacagaa ttgtcaaatg atcccatttc cttgagtctg tttttttttt   4440

tgtttttttt tgtttttttt ttggcagaga taatcgtgtc ttaaaagttg tttttaaatg   4500

acaataaaac aagccagaat gtctt                                         4525


<210>  687
<211>  1042
<212>  PRT
<213>  Homo sapiens

<400>  687


Met Glu Leu Gln Lys Gly Lys Gly Ala Ala Ala Ala Ala Ala Ala Ser 
1               5                   10                  15      


Gly Ala Ala Gly Gly Gly Gly Gly Gly Ala Gly Ala Gly Ala Pro Gly 
            20                  25                  30          


Gly Gly Arg Leu Leu Leu Ser Thr Ser Leu Asp Ala Lys Asp Glu Leu 
        35                  40                  45              


Glu Glu Arg Leu Glu Arg Cys Met Ser Ile Val Thr Ser Met Thr Ala 
    50                  55                  60                  


Gly Val Ser Glu Arg Glu Ala Asn Asp Ala Leu Asn Ala Tyr Val Cys 
65                  70                  75                  80  


Lys Gly Leu Pro Gln His Glu Glu Ile Cys Leu Gly Leu Phe Thr Leu 
                85                  90                  95      


Ile Leu Thr Glu Pro Ala Gln Ala Gln Lys Cys Tyr Arg Asp Leu Ala 
            100                 105                 110         


Leu Val Ser Arg Asp Gly Met Asn Ile Val Leu Asn Lys Ile Asn Gln 
        115                 120                 125             


Ile Leu Met Glu Lys Tyr Leu Lys Leu Gln Asp Thr Cys Arg Thr Gln 
    130                 135                 140                 


Leu Val Trp Leu Val Arg Glu Leu Val Lys Ser Gly Val Leu Gly Ala 
145                 150                 155                 160 


Asp Gly Val Cys Met Thr Phe Met Lys Gln Ile Ala Gly Gly Asp Val 
                165                 170                 175     


Thr Ala Lys Asn Ile Trp Leu Ala Glu Ser Val Leu Asp Ile Leu Thr 
            180                 185                 190         


Glu Gln Arg Glu Trp Val Leu Lys Ser Ser Ile Leu Ile Ala Met Ala 
        195                 200                 205             


Val Tyr Thr Tyr Leu Arg Leu Ile Val Asp His His Gly Thr Ala Gln 
    210                 215                 220                 


Leu Gln Ala Leu Arg Gln Lys Glu Val Asp Phe Cys Ile Ser Leu Leu 
225                 230                 235                 240 


Arg Glu Arg Phe Met Glu Cys Leu Met Ile Gly Arg Asp Leu Val Arg 
                245                 250                 255     


Leu Leu Gln Asn Val Ala Arg Ile Pro Glu Phe Glu Leu Leu Trp Lys 
            260                 265                 270         


Asp Ile Ile His Asn Pro Gln Ala Leu Ser Pro Gln Phe Thr Gly Ile 
        275                 280                 285             


Leu Gln Leu Leu Gln Ser Arg Thr Ser Arg Lys Phe Leu Ala Cys Arg 
    290                 295                 300                 


Leu Thr Pro Asp Met Glu Thr Lys Leu Leu Phe Met Thr Ser Arg Val 
305                 310                 315                 320 


Arg Phe Gly Gln Gln Lys Arg Tyr Gln Asp Trp Phe Gln Arg Gln Tyr 
                325                 330                 335     


Leu Ser Thr Pro Asp Ser Gln Ser Leu Arg Cys Asp Leu Ile Arg Tyr 
            340                 345                 350         


Ile Cys Gly Val Val His Pro Ser Asn Glu Val Leu Ser Ser Asp Ile 
        355                 360                 365             


Leu Pro Arg Trp Ala Ile Ile Gly Trp Leu Leu Thr Thr Cys Thr Ser 
    370                 375                 380                 


Asn Val Ala Ala Ser Asn Ala Lys Leu Ala Leu Phe Tyr Asp Trp Leu 
385                 390                 395                 400 


Phe Phe Ser Pro Asp Lys Asp Ser Ile Met Asn Ile Glu Pro Ala Ile 
                405                 410                 415     


Leu Val Met His His Ser Met Lys Pro His Pro Ala Ile Thr Ala Thr 
            420                 425                 430         


Leu Leu Asp Phe Met Cys Arg Ile Ile Pro Asn Phe Tyr Pro Pro Leu 
        435                 440                 445             


Glu Gly His Val Arg Gln Gly Val Phe Ser Ser Leu Asn His Ile Val 
    450                 455                 460                 


Glu Lys Arg Val Leu Ala His Leu Ala Pro Leu Phe Asp Asn Pro Lys 
465                 470                 475                 480 


Leu Asp Lys Glu Leu Arg Ala Met Leu Arg Glu Lys Phe Pro Glu Phe 
                485                 490                 495     


Cys Ser Ser Pro Ser Pro Pro Val Glu Val Lys Ile Glu Glu Pro Val 
            500                 505                 510         


Ser Met Glu Met Asp Asn His Met Ser Asp Lys Asp Glu Ser Cys Tyr 
        515                 520                 525             


Asp Asn Ala Glu Ala Ala Phe Ser Asp Asp Glu Glu Asp Leu Asn Ser 
    530                 535                 540                 


Lys Gly Lys Lys Arg Glu Phe Arg Phe His Pro Ile Lys Glu Thr Val 
545                 550                 555                 560 


Val Glu Glu Pro Val Asp Ile Thr Pro Tyr Leu Asp Gln Leu Asp Glu 
                565                 570                 575     


Ser Leu Arg Asp Lys Val Leu Gln Leu Gln Lys Gly Ser Asp Thr Glu 
            580                 585                 590         


Ala Gln Cys Glu Val Met Gln Glu Ile Val Asp Gln Val Leu Glu Glu 
        595                 600                 605             


Asp Phe Asp Ser Glu Gln Leu Ser Val Leu Ala Ser Cys Leu Gln Glu 
    610                 615                 620                 


Leu Phe Lys Ala His Phe Arg Gly Glu Val Leu Pro Glu Glu Ile Thr 
625                 630                 635                 640 


Glu Glu Ser Leu Glu Glu Ser Val Gly Lys Pro Leu Tyr Leu Ile Phe 
                645                 650                 655     


Arg Asn Leu Cys Gln Met Gln Glu Asp Asn Ser Ser Phe Ser Leu Leu 
            660                 665                 670         


Leu Asp Leu Leu Ser Glu Leu Tyr Gln Lys Gln Pro Lys Ile Gly Tyr 
        675                 680                 685             


His Leu Leu Tyr Tyr Leu Arg Ala Ser Lys Ala Ala Ala Gly Lys Met 
    690                 695                 700                 


Asn Leu Tyr Glu Ser Phe Ala Gln Ala Thr Gln Leu Gly Asp Leu His 
705                 710                 715                 720 


Thr Cys Leu Met Met Asp Met Lys Ala Cys Gln Glu Asp Asp Val Arg 
                725                 730                 735     


Leu Leu Cys His Leu Thr Pro Ser Ile Tyr Thr Glu Phe Pro Asp Glu 
            740                 745                 750         


Thr Leu Arg Ser Gly Glu Leu Leu Asn Met Ile Val Ala Val Ile Asp 
        755                 760                 765             


Ser Ala Gln Leu Gln Glu Leu Val Cys His Val Met Met Gly Asn Leu 
    770                 775                 780                 


Val Met Phe Arg Lys Asp Ser Val Leu Asn Ile Leu Ile Gln Ser Leu 
785                 790                 795                 800 


Asp Trp Glu Thr Phe Glu Gln Tyr Cys Ala Trp Gln Leu Phe Leu Ala 
                805                 810                 815     


His Asn Ile Pro Leu Glu Thr Ile Ile Pro Ile Leu Gln His Leu Lys 
            820                 825                 830         


Tyr Lys Glu His Pro Glu Ala Leu Ser Cys Leu Leu Leu Gln Leu Arg 
        835                 840                 845             


Arg Glu Lys Pro Ser Glu Glu Met Val Lys Met Val Leu Ser Arg Pro 
    850                 855                 860                 


Cys His Pro Asp Asp Gln Phe Thr Thr Ser Ile Leu Arg His Trp Cys 
865                 870                 875                 880 


Met Lys His Asp Glu Leu Leu Ala Glu His Ile Lys Ser Leu Leu Ile 
                885                 890                 895     


Lys Asn Asn Ser Leu Pro Arg Lys Arg Gln Ser Leu Arg Ser Ser Ser 
            900                 905                 910         


Ser Lys Leu Ala Gln Leu Thr Leu Glu Gln Ile Leu Glu His Leu Asp 
        915                 920                 925             


Asn Leu Arg Leu Asn Leu Thr Asn Thr Lys Gln Asn Phe Phe Ser Gln 
    930                 935                 940                 


Thr Pro Ile Leu Gln Ala Leu Gln His Val Gln Ala Ser Cys Asp Glu 
945                 950                 955                 960 


Ala His Lys Met Lys Phe Ser Asp Leu Phe Ser Leu Ala Glu Glu Tyr 
                965                 970                 975     


Glu Asp Ser Ser Thr Lys Pro Pro Lys Ser Arg Arg Lys Ala Ala Leu 
            980                 985                 990         


Ser Ser Pro Arg Ser Arg Lys Asn  Ala Thr Gln Pro Pro  Asn Ala Glu 
        995                 1000                 1005             


Glu Glu  Ser Gly Ser Ser Ser  Ala Ser Glu Glu Glu  Asp Thr Lys 
    1010                 1015                 1020             


Pro Lys  Pro Thr Lys Arg Lys  Arg Lys Gly Ser Ser  Ala Val Gly 
    1025                 1030                 1035             


Ser Asp  Ser Asp 
    1040         

<210>  688
<211>  235
<212>  DNA
<213>  Homo sapiens

<400>  688
tggtgttatt taagtttaag ggattagagg gcaaggggtc cactgtgggt ggggtgagga     60

ccttatcctc agcttgctgg ctgatcacaa actttacttc tcacagtgtt accgggactt    120

agctctggtg agtcgtgatg gcatgaatat tgtcctccgc ctcatcgtgg accaccatgg    180

gactgcccag ctccaggccc tgcgacagaa ggaagtagac ttctgcatct cactg         235


<210>  689
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  689


Met Asn Ile Val Leu Arg Leu Ile Val Asp His His Gly Thr Ala Gln 
1               5                   10                  15      


Leu Gln Ala Leu Arg Gln Lys Glu Val Asp Phe Cys Ile Ser 
            20                  25                  30  

<210>  690
<211>  1064
<212>  DNA
<213>  Homo sapiens

<400>  690
gtgatatgtg actttgtgaa cattgaattt tttaattgag acctggggca aggcatagtt     60

gtagctattt ttatcctctt tcctggcact tcttccctgt ttggcacttc cagcccctgc    120

ttcttatccc aagactggta tggcattgct gtgtgttaat tctgccccac agagtttcat    180

agcaagcact aaagactgtt acctggaaat aagaaactct tggcctgttg ggggcctcag    240

tgcaggactc aggacatcca gttgctagac tgcagctgtt gtcagccacc tgtacttctc    300

aggctctatc tgagatatca tcctttcttt ccaactgtgg gcttcttata tctacttctc    360

agacgttcat tttcaagggc caaaatgttc ccactccaac tcacaatctg tgggaaagta    420

gcagctctgg tttctagaaa aattcagaac cttccctttc cttctttctg gaggcaaagg    480

gtgaaacttt aaagcctgac agaacagaag gcagtttatc tcagcagtga agggatggca    540

gtaatgggat ggcagtcagg gtggaccagc agaatgggtg aagagatgta ttggattggc    600

tgacttgcta atcggagcta ttcttttttt ccccttttga aatcaggtgg agatgttaca    660

gccaaaaata tctggttggc agaaagtgtt ctggatatcc tgacagagca aagggagtgg    720

gtcctgaaga gcagcatcct cattgccatg gctgtttaca cgtacctccg cctcatcgtg    780

gaccaccatg ggactgccca gctccaggcc ctgcgacaga aggaagtaga cttctgcatc    840

tcactgcttc gggaacggtt catggaatgt ctgatgattg gtcgggatct cgtaagacta    900

cttcagaatg ttgctaggat accagaattt gaactgcttt ggaaagatat tatccataat    960

cctcaggcct tgagtcctca gttcacaggt aagtagggtc ttaggcatcc tgtccttgag   1020

agctgggagt tcaatgtgta tgtcttgctt gaatcaagaa ggta                    1064


<210>  691
<211>  82
<212>  PRT
<213>  Homo sapiens

<400>  691


Met Ala Val Tyr Thr Tyr Leu Arg Leu Ile Val Asp His His Gly Thr 
1               5                   10                  15      


Ala Gln Leu Gln Ala Leu Arg Gln Lys Glu Val Asp Phe Cys Ile Ser 
            20                  25                  30          


Leu Leu Arg Glu Arg Phe Met Glu Cys Leu Met Ile Gly Arg Asp Leu 
        35                  40                  45              


Val Arg Leu Leu Gln Asn Val Ala Arg Ile Pro Glu Phe Glu Leu Leu 
    50                  55                  60                  


Trp Lys Asp Ile Ile His Asn Pro Gln Ala Leu Ser Pro Gln Phe Thr 
65                  70                  75                  80  


Gly Lys 
        

<210>  692
<211>  305
<212>  DNA
<213>  Homo sapiens

<400>  692
tgaagaaact atgatttctt ctggaaccaa aggattggct cctagctgtt caggggaaga     60

gagctggaag ctggggactg atatcaagga tgagagggcc tggagctggg cagtcccatg    120

gtggtccacg atgaggcgga ggtacgtgta aacagccatg gcaatgagga tgctgctctt    180

caggacccac tccctgcagg gaggaaacac actggctcct atgctctgtc tagaactatt    240

caccctccca attcacgctt cttgggcttg gctacagtgc ctcagaaata attgatgatt    300

tgaca                                                                305


<210>  693
<211>  46
<212>  PRT
<213>  Homo sapiens

<400>  693


Met Ile Ser Ser Gly Thr Lys Gly Leu Ala Pro Ser Cys Ser Gly Glu 
1               5                   10                  15      


Glu Ser Trp Lys Leu Gly Thr Asp Ile Lys Asp Glu Arg Ala Trp Ser 
            20                  25                  30          


Trp Ala Val Pro Trp Trp Ser Thr Met Arg Arg Arg Tyr Val 
        35                  40                  45      

<210>  694
<211>  3044
<212>  DNA
<213>  Homo sapiens

<400>  694
gtagagatgg ggtttcactg tgttggccag gctggtctcg aactcctgac ctcaggtgat     60

ctgcccacct cggcctctca aagtactagg attatagacg tgagccaccg ggcccagcca    120

tttgtatatt ttctttggag aaatatctat tcaaaaatgt tcctattttt aattgagtta    180

tttgtctttt tattattgac ttttaagatt tttttttttt ttttttttga ggcagagtct    240

cgctctgctg cccagactgg agtgcagtgg cgcgagctcc actcactgca acctccgcat    300

gctaggttcc agcaattctc ctgcctcagc ctgctgagta gctgaaatta caggcgcaca    360

ccaccacgcc cggctaactt tttgtgtgtg tatttttagt agagacaggg tttcaccatg    420

ttggccaggc tggttggcca ggctggtctt gaacttctga cctcaggtga tccgcccttc    480

tctgcctccc aaagcgctgg gattacaggc atgagccacc atacccggcc aactttcaag    540

aatgttttta agattttgtt gcataccaaa agtgttcttt atatattctg gatgcaagtc    600

tcagacataa tgatttgcaa atattttttc ttccattctg cgagttttaa cttttttgat    660

agcatctttt gaacaaaaag tgctaacttt ttatgaagct aaatttgtct atttttttct    720

tttaccactt gtgtttttgt tgtcatgaag atttactcct gttttctctt ctacaagttg    780

tgtggcttta attcttacat ttaggcctac aagccatttt gagctaagtt tgtatatgct    840

gtgaggtgtc actgccctca tggttagagc ccagaaagca agagagaaag ccttctccag    900

cctgacctga gccctccctc ttctgttcct gactctcatc cggcagtagc ttcactcact    960

gatcgtggtt ggagcccttt tgagctctgg ggaaggatgg acagaaagaa gagtatcccc   1020

tggttcccct gagttatcaa gcccctgtgg gaggcagttg ggagggacat gaggcagatt   1080

agcacagggc atctggagcc agcaaagcag ttttagagcg ggagcctgct tcggggatgc   1140

ttgaaggtgg gcactggggt caggctgctg gctcaggccc agctggtctt gcagcaaagc   1200

cgccgcaggg aagatgaacc tgtacgagtc atttgcccag gctacccagc tgggcgatct   1260

gcacacctgc ctgatgatgg acatgaaggc ctgccaggag gacgatgtgc ggctcctgtg   1320

ccacctcacg ccctccatct acacagagtt tccagatgaa accttgagga gcggagagct   1380

gctgaacatg atcgtggctg ttattgactc tgcacagctc caggagctgg tctgccacgt   1440

gatgatgggt aacctggtta tgtttcgaaa agactcagtt ctcaacatac tcattcagag   1500

cctagactgg gagacctttg agcagtattg tgcctggcag ctctttctgg cccacaatat   1560

tcccctggag accataatcc ccatcctgca gcacctcaaa tacaaggagc acccagaggc   1620

cctgtcctgc ctactgcttc aactccgaag agaaaagccc agcgaggaga tggtgaagat   1680

ggtgctgagc cggccctgcc atcctgacga ccagttcacc accagcatcc tgcggcactg   1740

gtgcatgaaa catgacgagc tgctggccga gcacatcaag tccctgctca tcaagaacaa   1800

cagcctgcct cgcaagagac agagcctgag gagctctagc agcaagctgg cccagctgac   1860

tctggagcag atcctggagc acttggacaa tctgcggctc aacctgacca acaccaagca   1920

gaactttttt agccagacgc caattctcca ggcgctgcag catgtccaag cgagctgtga   1980

cgaagcccac aagatgaaat tcagtgatct cttctccctg gcggaggaat atgaggactc   2040

ttccaccaag ccacccaaga gccggcgaaa agcagctctg tccagccctc gaagtcgaaa   2100

gaatgccaca cagcccccca atgccgaaga agagtcgggc tccagcagtg cttcagaaga   2160

ggaagacacg aaaccgaagc ctaccaagcg gaaacgaaaa gggtcctctg cagtgggctc   2220

tgacagtgac tgaggccctg cattccccat cccacccccg gctggactgc cctctccttc   2280

ttggtgattc aaaggttaat agaggctgag gagattgcag gggaaacacc cttgctgcat   2340

ccccaagctc ccccggtgga aggaggagct ttctcctctg gctgagtttg agaagctgcc   2400

atgcagcccc tagccccttc cctcctcctg gggcctccag cccctcacac tgctgttccc   2460

agtgatattt gggatctgac tgaagccaga ggctctgtaa aatcagacca tagtggaagt   2520

cctcagcccc ctggcccctt ccgcaatctc ctcccccagt ctcccaaaga gccatttcaa   2580

cagagaaggg aaatgacaaa ggggcagctg gccagataag ctaggatgag agcagagact   2640

cagtgtgtgg gtgtcccttc ctgcttcccc ttcaggtctt ggtttgttct gaagggacgt   2700

tttatagtca ctatccacat gccagtgtga aatgggcatc tatgacgtgg tcagggtgtc   2760

cattcctaat catggggcag atgccacaag cattcagaaa ggagtctgaa agggtggcca   2820

cagccccacg tggtgtgccc tggaggctta ggttggtctg aggttggcac ctcaatctac   2880

accagagccc agggagtccc agaggcaagt ttcacagaat tgtcaaatga tcccatttcc   2940

ttgagtctgt tttttttttt gttttttttt gttttttttt tggcagagat aatcgtgtct   3000

taaaagttgt ttttaaatga caataaaaca agccagaatg tctt                    3044


<210>  695
<211>  339
<212>  PRT
<213>  Homo sapiens

<400>  695


Met Asn Leu Tyr Glu Ser Phe Ala Gln Ala Thr Gln Leu Gly Asp Leu 
1               5                   10                  15      


His Thr Cys Leu Met Met Asp Met Lys Ala Cys Gln Glu Asp Asp Val 
            20                  25                  30          


Arg Leu Leu Cys His Leu Thr Pro Ser Ile Tyr Thr Glu Phe Pro Asp 
        35                  40                  45              


Glu Thr Leu Arg Ser Gly Glu Leu Leu Asn Met Ile Val Ala Val Ile 
    50                  55                  60                  


Asp Ser Ala Gln Leu Gln Glu Leu Val Cys His Val Met Met Gly Asn 
65                  70                  75                  80  


Leu Val Met Phe Arg Lys Asp Ser Val Leu Asn Ile Leu Ile Gln Ser 
                85                  90                  95      


Leu Asp Trp Glu Thr Phe Glu Gln Tyr Cys Ala Trp Gln Leu Phe Leu 
            100                 105                 110         


Ala His Asn Ile Pro Leu Glu Thr Ile Ile Pro Ile Leu Gln His Leu 
        115                 120                 125             


Lys Tyr Lys Glu His Pro Glu Ala Leu Ser Cys Leu Leu Leu Gln Leu 
    130                 135                 140                 


Arg Arg Glu Lys Pro Ser Glu Glu Met Val Lys Met Val Leu Ser Arg 
145                 150                 155                 160 


Pro Cys His Pro Asp Asp Gln Phe Thr Thr Ser Ile Leu Arg His Trp 
                165                 170                 175     


Cys Met Lys His Asp Glu Leu Leu Ala Glu His Ile Lys Ser Leu Leu 
            180                 185                 190         


Ile Lys Asn Asn Ser Leu Pro Arg Lys Arg Gln Ser Leu Arg Ser Ser 
        195                 200                 205             


Ser Ser Lys Leu Ala Gln Leu Thr Leu Glu Gln Ile Leu Glu His Leu 
    210                 215                 220                 


Asp Asn Leu Arg Leu Asn Leu Thr Asn Thr Lys Gln Asn Phe Phe Ser 
225                 230                 235                 240 


Gln Thr Pro Ile Leu Gln Ala Leu Gln His Val Gln Ala Ser Cys Asp 
                245                 250                 255     


Glu Ala His Lys Met Lys Phe Ser Asp Leu Phe Ser Leu Ala Glu Glu 
            260                 265                 270         


Tyr Glu Asp Ser Ser Thr Lys Pro Pro Lys Ser Arg Arg Lys Ala Ala 
        275                 280                 285             


Leu Ser Ser Pro Arg Ser Arg Lys Asn Ala Thr Gln Pro Pro Asn Ala 
    290                 295                 300                 


Glu Glu Glu Ser Gly Ser Ser Ser Ala Ser Glu Glu Glu Asp Thr Lys 
305                 310                 315                 320 


Pro Lys Pro Thr Lys Arg Lys Arg Lys Gly Ser Ser Ala Val Gly Ser 
                325                 330                 335     


Asp Ser Asp 
            

<210>  696
<211>  3770
<212>  DNA
<213>  Homo sapiens

<400>  696
gtagagatgg ggtttcactg tgttggccag gctggtctcg aactcctgac ctcaggtgat     60

ctgcccacct cggcctctca aagtactagg attatagacg tgagccaccg ggcccagcca    120

tttgtatatt ttctttggag aaatatctat tcaaaaatgt tcctattttt aattgagtta    180

tttgtctttt tattattgac ttttaagatt tttttttttt ttttttttga ggcagagtct    240

cgctctgctg cccagactgg agtgcagtgg cgcgagctcc actcactgca acctccgcat    300

gctaggttcc agcaattctc ctgcctcagc ctgctgagta gctgaaatta caggcgcaca    360

ccaccacgcc cggctaactt tttgtgtgtg tatttttagt agagacaggg tttcaccatg    420

ttggccaggc tggttggcca ggctggtctt gaacttctga cctcaggtga tccgcccttc    480

tctgcctccc aaagcgctgg gattacaggc atgagccacc atacccggcc aactttcaag    540

aatgttttta agattttgtt gcataccaaa agtgttcttt atatattctg gatgcaagtc    600

tcagacataa tgatttgcaa atattttttc ttccattctg cgagttttaa cttttttgat    660

agcatctttt gaacaaaaag tgctaacttt ttatgaagct aaatttgtct atttttttct    720

tttaccactt gtgtttttgt tgtcatgaag atttactcct gttttctctt ctacaagttg    780

tgtggcttta attcttacat ttaggcctac aagccatttt gagctaagtt tgtatatgct    840

gtgaggtgtc actgccctca tggttagagc ccagaaagca agagagaaag ccttctccag    900

cctgacctga gccctccctc ttctgttcct gactctcatc cggcagtagc ttcactcact    960

gatcgtggtt ggagcccttt tgagctctgg ggaaggatgg acagaaagaa gagtatcccc   1020

tggttcccct gagttatcaa gcccctgtgg gaggcagttg ggagggacat gaggcagatt   1080

agcacagggc atctggagcc agcaaagcag ttttagagcg ggagcctgct tcggggatgc   1140

ttgaaggtgg gcactggggt caggctgctg gctcaggccc agctggtctt gcagcaaagc   1200

cgccgcaggg aagatgaacc tgtacgagtc atttgcccag gctacccagc tgggcgatct   1260

gcacacctgc ctgatgatgg acatgaaggc ctgccaggag gacgatgtgc ggctcctgtg   1320

ccacctcacg ccctccatct acacagagtt tccagatgaa accttgagga gcggagagct   1380

gctgaacatg atcgtggctg ttattgactc tgcacagctc caggagctgg tctgccacgt   1440

gatgatgggt aacctggtta tgtttcgaaa agactcagtt ctcaacatac tcattcagag   1500

cctagactgg gagacctttg agcagtattg tgcctggcag ctctttctgg cccacaatat   1560

tcccctggag accataatcc ccatcctgca gcacctcaaa tacaaggagc acccagaggc   1620

cctgtcctgc ctactgcttc aactccgaag agaaaagccc agcgaggaga tggtgaagat   1680

ggtgctgagc cggccctgcc atcctgacga ccagttcacc accagcatcc tgcggcactg   1740

gtgcatgaaa catgacgagc tgctggccga gcacatcaag tccctgctca tcaagaacaa   1800

cagcctgcct cgcaagagac agagcctgag gagctctagc agcaagctgg cccagctgac   1860

tctggagcag atcctggagc acttggacaa tctgcggctc aacctgacca acaccaagca   1920

gaactttttt agccagacgc caattctcca ggcgctgcag catgtccaag cgagctgtga   1980

cgaagcccac aagatgaaat tcagtgatct cttctccctg gcggaggaat atgaggactc   2040

ttccaccaag ccacccaaga gccggcgaaa agcagctctg tccagccctc gaagtcgaaa   2100

gaatgccaca cagcccccca atgccgaaga agagtcgggc tccagcagtg cttcagaaga   2160

ggaagacacg aaaccgaagc ctaccaagcg gaaacgaaaa gggtcctctg cagtgggctc   2220

tgacagtgac tgaggccctg cattccccat cccacccccg gctggactgc cctctccttc   2280

ttggtgattc aaaggttaat agaggctgag gagattgcag gggaaacacc cttgctgcat   2340

ccccaagctc ccccggtgga aggaggagct ttctcctctg gctgagtttg agaagctgcc   2400

atgcagcccc tagccccttc cctcctcctg gggcctccag cccctcacac tgctgttccc   2460

agtgatattt gggatctgac tgaagccaga ggctctgtaa aatcagacca tagtggaagt   2520

cctcagcccc ctggcccctt ccgcaatctc ctcccccagt ctcccaaaga gccatttcaa   2580

cagagaaggg aaatgacaaa ggggcagctg gccagataag ctaggatgag agcagagact   2640

cagtgtgtgg gtgtcccttc ctgcttcccc ttcaggtctt ggtttgttct gaagggacgt   2700

tttatagtca ctatccacat gccagtgtga aatgggcatc tatgacgtgg tcagggtgtc   2760

cattcctaat catggggcag atgccacaag cattcagaaa ggagtctgaa agggtggcca   2820

cagccccacg tggtgtgccc tggaggctta ggttggtctg aggttggcac ctcaatctac   2880

accagagccc agggagtccc agaggcaagt ttcacagaat tgtcaaatga tcccatttcc   2940

ttgagtctgt tttttttttt gttttttttt gttttttttt tggcagagat aatcgtgtct   3000

taaaagttgt ttttaaatga caataaaaca agccagaatg tcttttgtgc tggagtgtct   3060

gctggcattt gccccgtgca tgtatagctt ggtcttgatt tgattggcac ccctacttgt   3120

aaccgcagaa catccccctt tcccttcctg ttctgccccc acttttgtct agagcagaag   3180

ggacttggct ttggccacta cccatccttc ctgctgccac tggaggtggg agccaggcac   3240

tgatctgtct atgcagaacc atcccccgta ggatgaggcc tgtccttact catttctcaa   3300

gaaacaagat gcttccaaaa ggtctgtcat cctccagttg aagtctgtgt gcctaccaag   3360

aatggccgga ggactcgctg cttgacggga gggatgctcc agcttggtct ccagggacaa   3420

ctgtacctgg agataaagtc tggataccag ggagggacag agatgctctt ccttccacag   3480

tgtggccact tgctgggcca tgtgaaccag cagaggagag ttccttggct atgctgttgt   3540

tcccccgctg tccagggaga atggaggtgg actgaggagt gaagtttggg cgaactgcac   3600

agagctgctc ctcttcaccc cgaaaatttg tctttttaca gaatccaggt tctcccctcc   3660

ctcatcactg ctgttgcttc ctttgaaagt ctaaaccact ggaggcttct ttttccttcc   3720

tctctccttc cccagtttcc tctgtcccaa ttaaaaccag gatggagagc              3770


<210>  697
<211>  339
<212>  PRT
<213>  Homo sapiens

<400>  697


Met Asn Leu Tyr Glu Ser Phe Ala Gln Ala Thr Gln Leu Gly Asp Leu 
1               5                   10                  15      


His Thr Cys Leu Met Met Asp Met Lys Ala Cys Gln Glu Asp Asp Val 
            20                  25                  30          


Arg Leu Leu Cys His Leu Thr Pro Ser Ile Tyr Thr Glu Phe Pro Asp 
        35                  40                  45              


Glu Thr Leu Arg Ser Gly Glu Leu Leu Asn Met Ile Val Ala Val Ile 
    50                  55                  60                  


Asp Ser Ala Gln Leu Gln Glu Leu Val Cys His Val Met Met Gly Asn 
65                  70                  75                  80  


Leu Val Met Phe Arg Lys Asp Ser Val Leu Asn Ile Leu Ile Gln Ser 
                85                  90                  95      


Leu Asp Trp Glu Thr Phe Glu Gln Tyr Cys Ala Trp Gln Leu Phe Leu 
            100                 105                 110         


Ala His Asn Ile Pro Leu Glu Thr Ile Ile Pro Ile Leu Gln His Leu 
        115                 120                 125             


Lys Tyr Lys Glu His Pro Glu Ala Leu Ser Cys Leu Leu Leu Gln Leu 
    130                 135                 140                 


Arg Arg Glu Lys Pro Ser Glu Glu Met Val Lys Met Val Leu Ser Arg 
145                 150                 155                 160 


Pro Cys His Pro Asp Asp Gln Phe Thr Thr Ser Ile Leu Arg His Trp 
                165                 170                 175     


Cys Met Lys His Asp Glu Leu Leu Ala Glu His Ile Lys Ser Leu Leu 
            180                 185                 190         


Ile Lys Asn Asn Ser Leu Pro Arg Lys Arg Gln Ser Leu Arg Ser Ser 
        195                 200                 205             


Ser Ser Lys Leu Ala Gln Leu Thr Leu Glu Gln Ile Leu Glu His Leu 
    210                 215                 220                 


Asp Asn Leu Arg Leu Asn Leu Thr Asn Thr Lys Gln Asn Phe Phe Ser 
225                 230                 235                 240 


Gln Thr Pro Ile Leu Gln Ala Leu Gln His Val Gln Ala Ser Cys Asp 
                245                 250                 255     


Glu Ala His Lys Met Lys Phe Ser Asp Leu Phe Ser Leu Ala Glu Glu 
            260                 265                 270         


Tyr Glu Asp Ser Ser Thr Lys Pro Pro Lys Ser Arg Arg Lys Ala Ala 
        275                 280                 285             


Leu Ser Ser Pro Arg Ser Arg Lys Asn Ala Thr Gln Pro Pro Asn Ala 
    290                 295                 300                 


Glu Glu Glu Ser Gly Ser Ser Ser Ala Ser Glu Glu Glu Asp Thr Lys 
305                 310                 315                 320 


Pro Lys Pro Thr Lys Arg Lys Arg Lys Gly Ser Ser Ala Val Gly Ser 
                325                 330                 335     


Asp Ser Asp 
            

<210>  698
<211>  5332
<212>  DNA
<213>  Homo sapiens

<400>  698
gtagagatgg ggtttcactg tgttggccag gctggtctcg aactcctgac ctcaggtgat     60

ctgcccacct cggcctctca aagtactagg attatagacg tgagccaccg ggcccagcca    120

tttgtatatt ttctttggag aaatatctat tcaaaaatgt tcctattttt aattgagtta    180

tttgtctttt tattattgac ttttaagatt tttttttttt ttttttttga ggcagagtct    240

cgctctgctg cccagactgg agtgcagtgg cgcgagctcc actcactgca acctccgcat    300

gctaggttcc agcaattctc ctgcctcagc ctgctgagta gctgaaatta caggcgcaca    360

ccaccacgcc cggctaactt tttgtgtgtg tatttttagt agagacaggg tttcaccatg    420

ttggccaggc tggttggcca ggctggtctt gaacttctga cctcaggtga tccgcccttc    480

tctgcctccc aaagcgctgg gattacaggc atgagccacc atacccggcc aactttcaag    540

aatgttttta agattttgtt gcataccaaa agtgttcttt atatattctg gatgcaagtc    600

tcagacataa tgatttgcaa atattttttc ttccattctg cgagttttaa cttttttgat    660

agcatctttt gaacaaaaag tgctaacttt ttatgaagct aaatttgtct atttttttct    720

tttaccactt gtgtttttgt tgtcatgaag atttactcct gttttctctt ctacaagttg    780

tgtggcttta attcttacat ttaggcctac aagccatttt gagctaagtt tgtatatgct    840

gtgaggtgtc actgccctca tggttagagc ccagaaagca agagagaaag ccttctccag    900

cctgacctga gccctccctc ttctgttcct gactctcatc cggcagtagc ttcactcact    960

gatcgtggtt ggagcccttt tgagctctgg ggaaggatgg acagaaagaa gagtatcccc   1020

tggttcccct gagttatcaa gcccctgtgg gaggcagttg ggagggacat gaggcagatt   1080

agcacagggc atctggagcc agcaaagcag ttttagagcg ggagcctgct tcggggatgc   1140

ttgaaggtgg gcactggggt caggctgctg gctcaggccc agctggtctt gcagcaaagc   1200

cgccgcaggg aagatgaacc tgtacgagtc atttgcccag gctacccagc tgggcgatct   1260

gcacacctgc ctgatgatgg acatgaaggc ctgccaggag gacgatgtgc ggctcctgtg   1320

ccacctcacg ccctccatct acacagagtt tccagatgaa accttgagga gcggagagct   1380

gctgaacatg atcgtggctg ttattgactc tgcacagctc caggagctgg tctgccacgt   1440

gatgatgggt aacctggtta tgtttcgaaa agactcagtt ctcaacatac tcattcagag   1500

cctagactgg gagacctttg agcagtattg tgcctggcag ctctttctgg cccacaatat   1560

tcccctggag accataatcc ccatcctgca gcacctcaaa tacaaggagc acccagaggc   1620

cctgtcctgc ctactgcttc aactccgaag agaaaagccc agcgaggaga tggtgaagat   1680

ggtgctgagc cggccctgcc atcctgacga ccagttcacc accagcatcc tgcggcactg   1740

gtgcatgaaa catgacgagc tgctggccga gcacatcaag tccctgctca tcaagaacaa   1800

cagcctgcct cgcaagagac agagcctgag gagctctagc agcaagctgg cccagctgac   1860

tctggagcag atcctggagc acttggacaa tctgcggctc aacctgacca acaccaagca   1920

gaactttttt agccagacgc caattctcca ggcgctgcag catgtccaag cgagctgtga   1980

cgaagcccac aagatgaaat tcagtgatct cttctccctg gcggaggaat atgaggactc   2040

ttccaccaag ccacccaaga gccggcgaaa agcagctctg tccagccctc gaagtcgaaa   2100

gaatgccaca cagcccccca atgccgaaga agagtcgggc tccagcagtg cttcagaaga   2160

ggaagacacg aaaccgaagc ctaccaagcg gaaacgaaaa gggtcctctg cagtgggctc   2220

tgacagtgac tgaggccctg cattccccat cccacccccg gctggactgc cctctccttc   2280

ttggtgattc aaaggttaat agaggctgag gagattgcag gggaaacacc cttgctgcat   2340

ccccaagctc ccccggtgga aggaggagct ttctcctctg gctgagtttg agaagctgcc   2400

atgcagcccc tagccccttc cctcctcctg gggcctccag cccctcacac tgctgttccc   2460

agtgatattt gggatctgac tgaagccaga ggctctgtaa aatcagacca tagtggaagt   2520

cctcagcccc ctggcccctt ccgcaatctc ctcccccagt ctcccaaaga gccatttcaa   2580

cagagaaggg aaatgacaaa ggggcagctg gccagataag ctaggatgag agcagagact   2640

cagtgtgtgg gtgtcccttc ctgcttcccc ttcaggtctt ggtttgttct gaagggacgt   2700

tttatagtca ctatccacat gccagtgtga aatgggcatc tatgacgtgg tcagggtgtc   2760

cattcctaat catggggcag atgccacaag cattcagaaa ggagtctgaa agggtggcca   2820

cagccccacg tggtgtgccc tggaggctta ggttggtctg aggttggcac ctcaatctac   2880

accagagccc agggagtccc agaggcaagt ttcacagaat tgtcaaatga tcccatttcc   2940

ttgagtctgt tttttttttt gttttttttt gttttttttt tggcagagat aatcgtgtct   3000

taaaagttgt ttttaaatga caataaaaca agccagaatg tcttttgtgc tggagtgtct   3060

gctggcattt gccccgtgca tgtatagctt ggtcttgatt tgattggcac ccctacttgt   3120

aaccgcagaa catccccctt tcccttcctg ttctgccccc acttttgtct agagcagaag   3180

ggacttggct ttggccacta cccatccttc ctgctgccac tggaggtggg agccaggcac   3240

tgatctgtct atgcagaacc atcccccgta ggatgaggcc tgtccttact catttctcaa   3300

gaaacaagat gcttccaaaa ggtctgtcat cctccagttg aagtctgtgt gcctaccaag   3360

aatggccgga ggactcgctg cttgacggga gggatgctcc agcttggtct ccagggacaa   3420

ctgtacctgg agataaagtc tggataccag ggagggacag agatgctctt ccttccacag   3480

tgtggccact tgctgggcca tgtgaaccag cagaggagag ttccttggct atgctgttgt   3540

tcccccgctg tccagggaga atggaggtgg actgaggagt gaagtttggg cgaactgcac   3600

agagctgctc ctcttcaccc cgaaaatttg tctttttaca gaatccaggt tctcccctcc   3660

ctcatcactg ctgttgcttc ctttgaaagt ctaaaccact ggaggcttct ttttccttcc   3720

tctctccttc cccagtttcc tctgtcccaa ttaaaaccag gatggagagc atttgctggc   3780

tggccccaat tattgtaccc ttgcccaaag ggaggggcct ctgtcgtgac ccctcagaaa   3840

tctggcagtc tgggtttcca cctttcccct atttaactct cagcccccac ccatcccctg   3900

gggttgcggc tggcaggccg ggacttgcag aaccaaatgg gccaggggcc aagttcattc   3960

ttttgggaga gagcaatggt accttccctt aacgggaaaa cgagaaatat tgaggggaag   4020

atggactgcg atccaaacgc cctggctctc aggcctggac tctagggctt agccagatgc   4080

ctaaaccgcc caagccgaga aacaacttag aagacagaca taaccctggg attcagggaa   4140

ggcgcgagca ccgcccagga cctggtaggg tgcgagccgc gagcagtccg ggagggagcg   4200

cgcctagggc ggagcgtagg ctgtgggggg agggctggga gtccggggcc gccccacacc   4260

cgcactcctc ccgggtttct gctctccgcc cgtgtggagt ggtgggggcc tgggtgggaa   4320

tgggcgtgtg ccagcgcacg cgcgctccct ggaaggagaa gtctcagcta gaacgagcgg   4380

ccctaggttt tcggaaggga ggatcaggga tgtttgcgag cggctggaac cagacggtgc   4440

cgatagagga agcgggctcc atggctgccc tcctgctgct gcccctgctg ctgttgctac   4500

cgctgctgct gctgaagcta cacctctggc cgcagttgcg ctggcttccg gcggacttgg   4560

cctttgcggt gcgagctctg tgctgcaaaa gggctcttcg agctcgcgcc ctggccgcgg   4620

ctgccgccga cccggaaggt cccgaggggg gctgcagcct ggcctggcgc ctcgcggaac   4680

tggcccagca gcgcgccgcg cacacctttc tcattcacgg ctcgcggcgc tttagctact   4740

cagaggcgga gcgcgagagt aacagggctg cacgcgcctt cctacgtgcg ctaggctggg   4800

actggggacc cgacggcggc gacagcggcg aggggagcgc tggagaaggc gagcgggcag   4860

cgccgggagc cggagatgca gcggccggaa gcggcgcgga gtttgccgga ggggacggtg   4920

ccgccagagg tggaggagcc gccgcccctc tgtcacctgg agcaactgtg gcgctgctcc   4980

tccccgctgg cccagagttt ctgtggctct ggttcgggct ggccaaggcc ggcctgcgca   5040

ctgcctttgt gcccaccgcc ctgcgccggg gccccctgct gcactgcctc cgcagctgcg   5100

gcgcgcgcgc gctggtgctg gcgccaggta aggctggagc tccgaactga ctaaggcggg   5160

gccagccaca gaagggggcg tgtcggagac cacagaaagg cttggtctca tccctgggcc   5220

tgggaagaag ccgactatcc cttggggttc gaaagtgggt ggagatagga gtctccgggt   5280

ttgagaaggg atgaggctga atctttggtg ccccaaggat ccccaaggag tc           5332


<210>  699
<211>  339
<212>  PRT
<213>  Homo sapiens

<400>  699


Met Asn Leu Tyr Glu Ser Phe Ala Gln Ala Thr Gln Leu Gly Asp Leu 
1               5                   10                  15      


His Thr Cys Leu Met Met Asp Met Lys Ala Cys Gln Glu Asp Asp Val 
            20                  25                  30          


Arg Leu Leu Cys His Leu Thr Pro Ser Ile Tyr Thr Glu Phe Pro Asp 
        35                  40                  45              


Glu Thr Leu Arg Ser Gly Glu Leu Leu Asn Met Ile Val Ala Val Ile 
    50                  55                  60                  


Asp Ser Ala Gln Leu Gln Glu Leu Val Cys His Val Met Met Gly Asn 
65                  70                  75                  80  


Leu Val Met Phe Arg Lys Asp Ser Val Leu Asn Ile Leu Ile Gln Ser 
                85                  90                  95      


Leu Asp Trp Glu Thr Phe Glu Gln Tyr Cys Ala Trp Gln Leu Phe Leu 
            100                 105                 110         


Ala His Asn Ile Pro Leu Glu Thr Ile Ile Pro Ile Leu Gln His Leu 
        115                 120                 125             


Lys Tyr Lys Glu His Pro Glu Ala Leu Ser Cys Leu Leu Leu Gln Leu 
    130                 135                 140                 


Arg Arg Glu Lys Pro Ser Glu Glu Met Val Lys Met Val Leu Ser Arg 
145                 150                 155                 160 


Pro Cys His Pro Asp Asp Gln Phe Thr Thr Ser Ile Leu Arg His Trp 
                165                 170                 175     


Cys Met Lys His Asp Glu Leu Leu Ala Glu His Ile Lys Ser Leu Leu 
            180                 185                 190         


Ile Lys Asn Asn Ser Leu Pro Arg Lys Arg Gln Ser Leu Arg Ser Ser 
        195                 200                 205             


Ser Ser Lys Leu Ala Gln Leu Thr Leu Glu Gln Ile Leu Glu His Leu 
    210                 215                 220                 


Asp Asn Leu Arg Leu Asn Leu Thr Asn Thr Lys Gln Asn Phe Phe Ser 
225                 230                 235                 240 


Gln Thr Pro Ile Leu Gln Ala Leu Gln His Val Gln Ala Ser Cys Asp 
                245                 250                 255     


Glu Ala His Lys Met Lys Phe Ser Asp Leu Phe Ser Leu Ala Glu Glu 
            260                 265                 270         


Tyr Glu Asp Ser Ser Thr Lys Pro Pro Lys Ser Arg Arg Lys Ala Ala 
        275                 280                 285             


Leu Ser Ser Pro Arg Ser Arg Lys Asn Ala Thr Gln Pro Pro Asn Ala 
    290                 295                 300                 


Glu Glu Glu Ser Gly Ser Ser Ser Ala Ser Glu Glu Glu Asp Thr Lys 
305                 310                 315                 320 


Pro Lys Pro Thr Lys Arg Lys Arg Lys Gly Ser Ser Ala Val Gly Ser 
                325                 330                 335     


Asp Ser Asp 
            

<210>  700
<211>  2891
<212>  DNA
<213>  Homo sapiens

<400>  700
aggcgcacac caccacgccc ggctaacttt ttgtgtgtgt atttttagta gagacagggt     60

ttcaccatgt tggccaggct ggttggccag gctggtcttg aacttctgac ctcaggtgat    120

ccgcccttct ctgcctccca aagcgctggg attacaggca tgagccacca tacccggcca    180

actttcaaga atgtttttaa gattttgttg cataccaaaa gtgttcttta tatattctgg    240

atgcaagtct cagacataat gatttgcaaa tattttttct tccattctgc gagttttaac    300

ttttttgata gcatcttttg aacaaaaagt gctaactttt tatgaagcta aatttgtcta    360

tttttttctt ttaccacttg tgtttttgtt gtcatgaaga tttactcctg ttttctcttc    420

tacaagttgt gtggctttaa ttcttacatt taggcctaca agccattttg agctaagttt    480

gtatatgctg tgaggtgtca ctgccctcat ggttagagcc cagaaagcaa gagagaaagc    540

cttctccagc ctgacctgag ccctccctct tctgttcctg actctcatcc ggcagtagct    600

tcactcactg atcgtggttg gagccctttt gagctctggg gaaggatgga cagaaagaag    660

agtatcccct ggttcccctg agttatcaag cccctgtggg aggcagttgg gagggacatg    720

aggcagatta gcacagggca tctggagcca gcaaagcagt tttagagcgg gagcctgctt    780

cggggatgct tgaaggtggg cactggggtc aggctgctgg ctcaggccca gctggtcttg    840

cagcaaagcc gccgcaggga agatgaacct gtacgagtca tttgcccagg ctacccagct    900

gggcgatctg cacacctgcc tgatgatgga catgaaggcc tgccaggagg acgatgtgcg    960

gctcctgtgc cacctcacgc cctccatcta cacagagttt ccagatgaaa ccttgaggag   1020

cggagagctg ctgaacatga tcgtggctgt tattgactct gcacagctcc aggagctggt   1080

ctgccacgtg atgatgggta acctggttat gtttcgaaaa gactcagttc tcaacatact   1140

cattcagagc ctagactggg agacctttga gcagtattgt gcctggcagc tctttctggc   1200

ccacaatatt cccctggaga ccataatccc catcctgcag cacctcaaat acaaggagca   1260

cccagaggcc ctgtcctgcc tactgcttca actccgaaga gaaaagccca gcgaggagat   1320

ggtgaagatg gtgctgagcc ggccctgcca tcctgacgac cagttcacca ccagcatcct   1380

gcggcactgg tgcatgaaac atgacgagct gctggccgag cacatcaagt ccctgctcat   1440

caagaacaac agcctgcctc gcaagagaca gagcctgagg agctctagca gcaagctggc   1500

ccagctgact ctggagcaga tcctggagca cttggacaat ctgcggctca acctgaccaa   1560

caccaagcag aactgtatgc cttccaccct cggcgtccag tgtagacggt gctgccctgg   1620

cccagactat gcctggagcc aggctggggg caggggcagg acacccgggg ccacaaccca   1680

cactcgggat aaaacaacct gtgcgtgctg tttaataagc tcccagacat ctgattgttt   1740

ttccttccct gctctccctt ttcttcctct agtttttagc cagacgccaa ttctccaggc   1800

gctgcagcat gtccaagcga gctgtgacga agcccacaag atgaaattca gtgatctctt   1860

ctccctggcg gaggaatatg aggactcttc caccaagcca cccaagagcc ggcgaaaagc   1920

agctctgtcc agccctcgaa gtcgaaagaa tgccacacag ccccccaatg ccgaagaaga   1980

gtcgggctcc agcagtgctt cagaagagga agacacgaaa ccgaagccta ccaagcggaa   2040

acgaaaaggg tcctctgcag tgggctctga cagtgactga ggccctgcat tccccatccc   2100

acccccggct ggactgccct ctccttcttg gtgattcaaa ggttaataga ggctgaggag   2160

attgcagggg aaacaccctt gctgcatccc caagctcccc cggtggaagg aggagctttc   2220

tcctctggct gagtttgaga agctgccatg cagcccctag ccccttccct cctcctgggg   2280

cctccagccc ctcacactgc tgttcccagt gatatttggg atctgactga agccagaggc   2340

tctgtaaaat cagaccatag tggaagtcct cagccccctg gccccttccg caatctcctc   2400

ccccagtctc ccaaagagcc atttcaacag agaagggaaa tgacaaaggg gcagctggcc   2460

agataagcta ggatgagagc agagactcag tgtgtgggtg tcccttcctg cttccccttc   2520

aggtcttggt ttgttctgaa gggacgtttt atagtcacta tccacatgcc agtgtgaaat   2580

gggcatctat gacgtggtca gggtgtccat tcctaatcat ggggcagatg ccacaagcat   2640

tcagaaagga gtctgaaagg gtggccacag ccccacgtgg tgtgccctgg aggcttaggt   2700

tggtctgagg ttggcacctc aatctacacc agagcccagg gagtcccaga ggcaagtttc   2760

acagaattgt caaatgatcc catttccttg agtctgtttt tttttttgtt tttttttgtt   2820

ttttttttgg cagagataat cgtgtcttaa aagttgtttt taaatgacaa taaaacaagc   2880

cagaatgtct t                                                        2891


<210>  701
<211>  405
<212>  PRT
<213>  Homo sapiens

<400>  701


Met Asn Leu Tyr Glu Ser Phe Ala Gln Ala Thr Gln Leu Gly Asp Leu 
1               5                   10                  15      


His Thr Cys Leu Met Met Asp Met Lys Ala Cys Gln Glu Asp Asp Val 
            20                  25                  30          


Arg Leu Leu Cys His Leu Thr Pro Ser Ile Tyr Thr Glu Phe Pro Asp 
        35                  40                  45              


Glu Thr Leu Arg Ser Gly Glu Leu Leu Asn Met Ile Val Ala Val Ile 
    50                  55                  60                  


Asp Ser Ala Gln Leu Gln Glu Leu Val Cys His Val Met Met Gly Asn 
65                  70                  75                  80  


Leu Val Met Phe Arg Lys Asp Ser Val Leu Asn Ile Leu Ile Gln Ser 
                85                  90                  95      


Leu Asp Trp Glu Thr Phe Glu Gln Tyr Cys Ala Trp Gln Leu Phe Leu 
            100                 105                 110         


Ala His Asn Ile Pro Leu Glu Thr Ile Ile Pro Ile Leu Gln His Leu 
        115                 120                 125             


Lys Tyr Lys Glu His Pro Glu Ala Leu Ser Cys Leu Leu Leu Gln Leu 
    130                 135                 140                 


Arg Arg Glu Lys Pro Ser Glu Glu Met Val Lys Met Val Leu Ser Arg 
145                 150                 155                 160 


Pro Cys His Pro Asp Asp Gln Phe Thr Thr Ser Ile Leu Arg His Trp 
                165                 170                 175     


Cys Met Lys His Asp Glu Leu Leu Ala Glu His Ile Lys Ser Leu Leu 
            180                 185                 190         


Ile Lys Asn Asn Ser Leu Pro Arg Lys Arg Gln Ser Leu Arg Ser Ser 
        195                 200                 205             


Ser Ser Lys Leu Ala Gln Leu Thr Leu Glu Gln Ile Leu Glu His Leu 
    210                 215                 220                 


Asp Asn Leu Arg Leu Asn Leu Thr Asn Thr Lys Gln Asn Cys Met Pro 
225                 230                 235                 240 


Ser Thr Leu Gly Val Gln Cys Arg Arg Cys Cys Pro Gly Pro Asp Tyr 
                245                 250                 255     


Ala Trp Ser Gln Ala Gly Gly Arg Gly Arg Thr Pro Gly Ala Thr Thr 
            260                 265                 270         


His Thr Arg Asp Lys Thr Thr Cys Ala Cys Cys Leu Ile Ser Ser Gln 
        275                 280                 285             


Thr Ser Asp Cys Phe Ser Phe Pro Ala Leu Pro Phe Leu Pro Leu Val 
    290                 295                 300                 


Phe Ser Gln Thr Pro Ile Leu Gln Ala Leu Gln His Val Gln Ala Ser 
305                 310                 315                 320 


Cys Asp Glu Ala His Lys Met Lys Phe Ser Asp Leu Phe Ser Leu Ala 
                325                 330                 335     


Glu Glu Tyr Glu Asp Ser Ser Thr Lys Pro Pro Lys Ser Arg Arg Lys 
            340                 345                 350         


Ala Ala Leu Ser Ser Pro Arg Ser Arg Lys Asn Ala Thr Gln Pro Pro 
        355                 360                 365             


Asn Ala Glu Glu Glu Ser Gly Ser Ser Ser Ala Ser Glu Glu Glu Asp 
    370                 375                 380                 


Thr Lys Pro Lys Pro Thr Lys Arg Lys Arg Lys Gly Ser Ser Ala Val 
385                 390                 395                 400 


Gly Ser Asp Ser Asp 
                405 

<210>  702
<211>  3617
<212>  DNA
<213>  Homo sapiens

<400>  702
aggcgcacac caccacgccc ggctaacttt ttgtgtgtgt atttttagta gagacagggt     60

ttcaccatgt tggccaggct ggttggccag gctggtcttg aacttctgac ctcaggtgat    120

ccgcccttct ctgcctccca aagcgctggg attacaggca tgagccacca tacccggcca    180

actttcaaga atgtttttaa gattttgttg cataccaaaa gtgttcttta tatattctgg    240

atgcaagtct cagacataat gatttgcaaa tattttttct tccattctgc gagttttaac    300

ttttttgata gcatcttttg aacaaaaagt gctaactttt tatgaagcta aatttgtcta    360

tttttttctt ttaccacttg tgtttttgtt gtcatgaaga tttactcctg ttttctcttc    420

tacaagttgt gtggctttaa ttcttacatt taggcctaca agccattttg agctaagttt    480

gtatatgctg tgaggtgtca ctgccctcat ggttagagcc cagaaagcaa gagagaaagc    540

cttctccagc ctgacctgag ccctccctct tctgttcctg actctcatcc ggcagtagct    600

tcactcactg atcgtggttg gagccctttt gagctctggg gaaggatgga cagaaagaag    660

agtatcccct ggttcccctg agttatcaag cccctgtggg aggcagttgg gagggacatg    720

aggcagatta gcacagggca tctggagcca gcaaagcagt tttagagcgg gagcctgctt    780

cggggatgct tgaaggtggg cactggggtc aggctgctgg ctcaggccca gctggtcttg    840

cagcaaagcc gccgcaggga agatgaacct gtacgagtca tttgcccagg ctacccagct    900

gggcgatctg cacacctgcc tgatgatgga catgaaggcc tgccaggagg acgatgtgcg    960

gctcctgtgc cacctcacgc cctccatcta cacagagttt ccagatgaaa ccttgaggag   1020

cggagagctg ctgaacatga tcgtggctgt tattgactct gcacagctcc aggagctggt   1080

ctgccacgtg atgatgggta acctggttat gtttcgaaaa gactcagttc tcaacatact   1140

cattcagagc ctagactggg agacctttga gcagtattgt gcctggcagc tctttctggc   1200

ccacaatatt cccctggaga ccataatccc catcctgcag cacctcaaat acaaggagca   1260

cccagaggcc ctgtcctgcc tactgcttca actccgaaga gaaaagccca gcgaggagat   1320

ggtgaagatg gtgctgagcc ggccctgcca tcctgacgac cagttcacca ccagcatcct   1380

gcggcactgg tgcatgaaac atgacgagct gctggccgag cacatcaagt ccctgctcat   1440

caagaacaac agcctgcctc gcaagagaca gagcctgagg agctctagca gcaagctggc   1500

ccagctgact ctggagcaga tcctggagca cttggacaat ctgcggctca acctgaccaa   1560

caccaagcag aactgtatgc cttccaccct cggcgtccag tgtagacggt gctgccctgg   1620

cccagactat gcctggagcc aggctggggg caggggcagg acacccgggg ccacaaccca   1680

cactcgggat aaaacaacct gtgcgtgctg tttaataagc tcccagacat ctgattgttt   1740

ttccttccct gctctccctt ttcttcctct agtttttagc cagacgccaa ttctccaggc   1800

gctgcagcat gtccaagcga gctgtgacga agcccacaag atgaaattca gtgatctctt   1860

ctccctggcg gaggaatatg aggactcttc caccaagcca cccaagagcc ggcgaaaagc   1920

agctctgtcc agccctcgaa gtcgaaagaa tgccacacag ccccccaatg ccgaagaaga   1980

gtcgggctcc agcagtgctt cagaagagga agacacgaaa ccgaagccta ccaagcggaa   2040

acgaaaaggg tcctctgcag tgggctctga cagtgactga ggccctgcat tccccatccc   2100

acccccggct ggactgccct ctccttcttg gtgattcaaa ggttaataga ggctgaggag   2160

attgcagggg aaacaccctt gctgcatccc caagctcccc cggtggaagg aggagctttc   2220

tcctctggct gagtttgaga agctgccatg cagcccctag ccccttccct cctcctgggg   2280

cctccagccc ctcacactgc tgttcccagt gatatttggg atctgactga agccagaggc   2340

tctgtaaaat cagaccatag tggaagtcct cagccccctg gccccttccg caatctcctc   2400

ccccagtctc ccaaagagcc atttcaacag agaagggaaa tgacaaaggg gcagctggcc   2460

agataagcta ggatgagagc agagactcag tgtgtgggtg tcccttcctg cttccccttc   2520

aggtcttggt ttgttctgaa gggacgtttt atagtcacta tccacatgcc agtgtgaaat   2580

gggcatctat gacgtggtca gggtgtccat tcctaatcat ggggcagatg ccacaagcat   2640

tcagaaagga gtctgaaagg gtggccacag ccccacgtgg tgtgccctgg aggcttaggt   2700

tggtctgagg ttggcacctc aatctacacc agagcccagg gagtcccaga ggcaagtttc   2760

acagaattgt caaatgatcc catttccttg agtctgtttt tttttttgtt tttttttgtt   2820

ttttttttgg cagagataat cgtgtcttaa aagttgtttt taaatgacaa taaaacaagc   2880

cagaatgtct tttgtgctgg agtgtctgct ggcatttgcc ccgtgcatgt atagcttggt   2940

cttgatttga ttggcacccc tacttgtaac cgcagaacat ccccctttcc cttcctgttc   3000

tgcccccact tttgtctaga gcagaaggga cttggctttg gccactaccc atccttcctg   3060

ctgccactgg aggtgggagc caggcactga tctgtctatg cagaaccatc ccccgtagga   3120

tgaggcctgt ccttactcat ttctcaagaa acaagatgct tccaaaaggt ctgtcatcct   3180

ccagttgaag tctgtgtgcc taccaagaat ggccggagga ctcgctgctt gacgggaggg   3240

atgctccagc ttggtctcca gggacaactg tacctggaga taaagtctgg ataccaggga   3300

gggacagaga tgctcttcct tccacagtgt ggccacttgc tgggccatgt gaaccagcag   3360

aggagagttc cttggctatg ctgttgttcc cccgctgtcc agggagaatg gaggtggact   3420

gaggagtgaa gtttgggcga actgcacaga gctgctcctc ttcaccccga aaatttgtct   3480

ttttacagaa tccaggttct cccctccctc atcactgctg ttgcttcctt tgaaagtcta   3540

aaccactgga ggcttctttt tccttcctct ctccttcccc agtttcctct gtcccaatta   3600

aaaccaggat ggagagc                                                  3617


<210>  703
<211>  405
<212>  PRT
<213>  Homo sapiens

<400>  703


Met Asn Leu Tyr Glu Ser Phe Ala Gln Ala Thr Gln Leu Gly Asp Leu 
1               5                   10                  15      


His Thr Cys Leu Met Met Asp Met Lys Ala Cys Gln Glu Asp Asp Val 
            20                  25                  30          


Arg Leu Leu Cys His Leu Thr Pro Ser Ile Tyr Thr Glu Phe Pro Asp 
        35                  40                  45              


Glu Thr Leu Arg Ser Gly Glu Leu Leu Asn Met Ile Val Ala Val Ile 
    50                  55                  60                  


Asp Ser Ala Gln Leu Gln Glu Leu Val Cys His Val Met Met Gly Asn 
65                  70                  75                  80  


Leu Val Met Phe Arg Lys Asp Ser Val Leu Asn Ile Leu Ile Gln Ser 
                85                  90                  95      


Leu Asp Trp Glu Thr Phe Glu Gln Tyr Cys Ala Trp Gln Leu Phe Leu 
            100                 105                 110         


Ala His Asn Ile Pro Leu Glu Thr Ile Ile Pro Ile Leu Gln His Leu 
        115                 120                 125             


Lys Tyr Lys Glu His Pro Glu Ala Leu Ser Cys Leu Leu Leu Gln Leu 
    130                 135                 140                 


Arg Arg Glu Lys Pro Ser Glu Glu Met Val Lys Met Val Leu Ser Arg 
145                 150                 155                 160 


Pro Cys His Pro Asp Asp Gln Phe Thr Thr Ser Ile Leu Arg His Trp 
                165                 170                 175     


Cys Met Lys His Asp Glu Leu Leu Ala Glu His Ile Lys Ser Leu Leu 
            180                 185                 190         


Ile Lys Asn Asn Ser Leu Pro Arg Lys Arg Gln Ser Leu Arg Ser Ser 
        195                 200                 205             


Ser Ser Lys Leu Ala Gln Leu Thr Leu Glu Gln Ile Leu Glu His Leu 
    210                 215                 220                 


Asp Asn Leu Arg Leu Asn Leu Thr Asn Thr Lys Gln Asn Cys Met Pro 
225                 230                 235                 240 


Ser Thr Leu Gly Val Gln Cys Arg Arg Cys Cys Pro Gly Pro Asp Tyr 
                245                 250                 255     


Ala Trp Ser Gln Ala Gly Gly Arg Gly Arg Thr Pro Gly Ala Thr Thr 
            260                 265                 270         


His Thr Arg Asp Lys Thr Thr Cys Ala Cys Cys Leu Ile Ser Ser Gln 
        275                 280                 285             


Thr Ser Asp Cys Phe Ser Phe Pro Ala Leu Pro Phe Leu Pro Leu Val 
    290                 295                 300                 


Phe Ser Gln Thr Pro Ile Leu Gln Ala Leu Gln His Val Gln Ala Ser 
305                 310                 315                 320 


Cys Asp Glu Ala His Lys Met Lys Phe Ser Asp Leu Phe Ser Leu Ala 
                325                 330                 335     


Glu Glu Tyr Glu Asp Ser Ser Thr Lys Pro Pro Lys Ser Arg Arg Lys 
            340                 345                 350         


Ala Ala Leu Ser Ser Pro Arg Ser Arg Lys Asn Ala Thr Gln Pro Pro 
        355                 360                 365             


Asn Ala Glu Glu Glu Ser Gly Ser Ser Ser Ala Ser Glu Glu Glu Asp 
    370                 375                 380                 


Thr Lys Pro Lys Pro Thr Lys Arg Lys Arg Lys Gly Ser Ser Ala Val 
385                 390                 395                 400 


Gly Ser Asp Ser Asp 
                405 

<210>  704
<211>  5179
<212>  DNA
<213>  Homo sapiens

<400>  704
aggcgcacac caccacgccc ggctaacttt ttgtgtgtgt atttttagta gagacagggt     60

ttcaccatgt tggccaggct ggttggccag gctggtcttg aacttctgac ctcaggtgat    120

ccgcccttct ctgcctccca aagcgctggg attacaggca tgagccacca tacccggcca    180

actttcaaga atgtttttaa gattttgttg cataccaaaa gtgttcttta tatattctgg    240

atgcaagtct cagacataat gatttgcaaa tattttttct tccattctgc gagttttaac    300

ttttttgata gcatcttttg aacaaaaagt gctaactttt tatgaagcta aatttgtcta    360

tttttttctt ttaccacttg tgtttttgtt gtcatgaaga tttactcctg ttttctcttc    420

tacaagttgt gtggctttaa ttcttacatt taggcctaca agccattttg agctaagttt    480

gtatatgctg tgaggtgtca ctgccctcat ggttagagcc cagaaagcaa gagagaaagc    540

cttctccagc ctgacctgag ccctccctct tctgttcctg actctcatcc ggcagtagct    600

tcactcactg atcgtggttg gagccctttt gagctctggg gaaggatgga cagaaagaag    660

agtatcccct ggttcccctg agttatcaag cccctgtggg aggcagttgg gagggacatg    720

aggcagatta gcacagggca tctggagcca gcaaagcagt tttagagcgg gagcctgctt    780

cggggatgct tgaaggtggg cactggggtc aggctgctgg ctcaggccca gctggtcttg    840

cagcaaagcc gccgcaggga agatgaacct gtacgagtca tttgcccagg ctacccagct    900

gggcgatctg cacacctgcc tgatgatgga catgaaggcc tgccaggagg acgatgtgcg    960

gctcctgtgc cacctcacgc cctccatcta cacagagttt ccagatgaaa ccttgaggag   1020

cggagagctg ctgaacatga tcgtggctgt tattgactct gcacagctcc aggagctggt   1080

ctgccacgtg atgatgggta acctggttat gtttcgaaaa gactcagttc tcaacatact   1140

cattcagagc ctagactggg agacctttga gcagtattgt gcctggcagc tctttctggc   1200

ccacaatatt cccctggaga ccataatccc catcctgcag cacctcaaat acaaggagca   1260

cccagaggcc ctgtcctgcc tactgcttca actccgaaga gaaaagccca gcgaggagat   1320

ggtgaagatg gtgctgagcc ggccctgcca tcctgacgac cagttcacca ccagcatcct   1380

gcggcactgg tgcatgaaac atgacgagct gctggccgag cacatcaagt ccctgctcat   1440

caagaacaac agcctgcctc gcaagagaca gagcctgagg agctctagca gcaagctggc   1500

ccagctgact ctggagcaga tcctggagca cttggacaat ctgcggctca acctgaccaa   1560

caccaagcag aactgtatgc cttccaccct cggcgtccag tgtagacggt gctgccctgg   1620

cccagactat gcctggagcc aggctggggg caggggcagg acacccgggg ccacaaccca   1680

cactcgggat aaaacaacct gtgcgtgctg tttaataagc tcccagacat ctgattgttt   1740

ttccttccct gctctccctt ttcttcctct agtttttagc cagacgccaa ttctccaggc   1800

gctgcagcat gtccaagcga gctgtgacga agcccacaag atgaaattca gtgatctctt   1860

ctccctggcg gaggaatatg aggactcttc caccaagcca cccaagagcc ggcgaaaagc   1920

agctctgtcc agccctcgaa gtcgaaagaa tgccacacag ccccccaatg ccgaagaaga   1980

gtcgggctcc agcagtgctt cagaagagga agacacgaaa ccgaagccta ccaagcggaa   2040

acgaaaaggg tcctctgcag tgggctctga cagtgactga ggccctgcat tccccatccc   2100

acccccggct ggactgccct ctccttcttg gtgattcaaa ggttaataga ggctgaggag   2160

attgcagggg aaacaccctt gctgcatccc caagctcccc cggtggaagg aggagctttc   2220

tcctctggct gagtttgaga agctgccatg cagcccctag ccccttccct cctcctgggg   2280

cctccagccc ctcacactgc tgttcccagt gatatttggg atctgactga agccagaggc   2340

tctgtaaaat cagaccatag tggaagtcct cagccccctg gccccttccg caatctcctc   2400

ccccagtctc ccaaagagcc atttcaacag agaagggaaa tgacaaaggg gcagctggcc   2460

agataagcta ggatgagagc agagactcag tgtgtgggtg tcccttcctg cttccccttc   2520

aggtcttggt ttgttctgaa gggacgtttt atagtcacta tccacatgcc agtgtgaaat   2580

gggcatctat gacgtggtca gggtgtccat tcctaatcat ggggcagatg ccacaagcat   2640

tcagaaagga gtctgaaagg gtggccacag ccccacgtgg tgtgccctgg aggcttaggt   2700

tggtctgagg ttggcacctc aatctacacc agagcccagg gagtcccaga ggcaagtttc   2760

acagaattgt caaatgatcc catttccttg agtctgtttt tttttttgtt tttttttgtt   2820

ttttttttgg cagagataat cgtgtcttaa aagttgtttt taaatgacaa taaaacaagc   2880

cagaatgtct tttgtgctgg agtgtctgct ggcatttgcc ccgtgcatgt atagcttggt   2940

cttgatttga ttggcacccc tacttgtaac cgcagaacat ccccctttcc cttcctgttc   3000

tgcccccact tttgtctaga gcagaaggga cttggctttg gccactaccc atccttcctg   3060

ctgccactgg aggtgggagc caggcactga tctgtctatg cagaaccatc ccccgtagga   3120

tgaggcctgt ccttactcat ttctcaagaa acaagatgct tccaaaaggt ctgtcatcct   3180

ccagttgaag tctgtgtgcc taccaagaat ggccggagga ctcgctgctt gacgggaggg   3240

atgctccagc ttggtctcca gggacaactg tacctggaga taaagtctgg ataccaggga   3300

gggacagaga tgctcttcct tccacagtgt ggccacttgc tgggccatgt gaaccagcag   3360

aggagagttc cttggctatg ctgttgttcc cccgctgtcc agggagaatg gaggtggact   3420

gaggagtgaa gtttgggcga actgcacaga gctgctcctc ttcaccccga aaatttgtct   3480

ttttacagaa tccaggttct cccctccctc atcactgctg ttgcttcctt tgaaagtcta   3540

aaccactgga ggcttctttt tccttcctct ctccttcccc agtttcctct gtcccaatta   3600

aaaccaggat ggagagcatt tgctggctgg ccccaattat tgtacccttg cccaaaggga   3660

ggggcctctg tcgtgacccc tcagaaatct ggcagtctgg gtttccacct ttcccctatt   3720

taactctcag cccccaccca tcccctgggg ttgcggctgg caggccggga cttgcagaac   3780

caaatgggcc aggggccaag ttcattcttt tgggagagag caatggtacc ttcccttaac   3840

gggaaaacga gaaatattga ggggaagatg gactgcgatc caaacgccct ggctctcagg   3900

cctggactct agggcttagc cagatgccta aaccgcccaa gccgagaaac aacttagaag   3960

acagacataa ccctgggatt cagggaaggc gcgagcaccg cccaggacct ggtagggtgc   4020

gagccgcgag cagtccggga gggagcgcgc ctagggcgga gcgtaggctg tggggggagg   4080

gctgggagtc cggggccgcc ccacacccgc actcctcccg ggtttctgct ctccgcccgt   4140

gtggagtggt gggggcctgg gtgggaatgg gcgtgtgcca gcgcacgcgc gctccctgga   4200

aggagaagtc tcagctagaa cgagcggccc taggttttcg gaagggagga tcagggatgt   4260

ttgcgagcgg ctggaaccag acggtgccga tagaggaagc gggctccatg gctgccctcc   4320

tgctgctgcc cctgctgctg ttgctaccgc tgctgctgct gaagctacac ctctggccgc   4380

agttgcgctg gcttccggcg gacttggcct ttgcggtgcg agctctgtgc tgcaaaaggg   4440

ctcttcgagc tcgcgccctg gccgcggctg ccgccgaccc ggaaggtccc gaggggggct   4500

gcagcctggc ctggcgcctc gcggaactgg cccagcagcg cgccgcgcac acctttctca   4560

ttcacggctc gcggcgcttt agctactcag aggcggagcg cgagagtaac agggctgcac   4620

gcgccttcct acgtgcgcta ggctgggact ggggacccga cggcggcgac agcggcgagg   4680

ggagcgctgg agaaggcgag cgggcagcgc cgggagccgg agatgcagcg gccggaagcg   4740

gcgcggagtt tgccggaggg gacggtgccg ccagaggtgg aggagccgcc gcccctctgt   4800

cacctggagc aactgtggcg ctgctcctcc ccgctggccc agagtttctg tggctctggt   4860

tcgggctggc caaggccggc ctgcgcactg cctttgtgcc caccgccctg cgccggggcc   4920

ccctgctgca ctgcctccgc agctgcggcg cgcgcgcgct ggtgctggcg ccaggtaagg   4980

ctggagctcc gaactgacta aggcggggcc agccacagaa gggggcgtgt cggagaccac   5040

agaaaggctt ggtctcatcc ctgggcctgg gaagaagccg actatccctt ggggttcgaa   5100

agtgggtgga gataggagtc tccgggtttg agaagggatg aggctgaatc tttggtgccc   5160

caaggatccc caaggagtc                                                5179


<210>  705
<211>  405
<212>  PRT
<213>  Homo sapiens

<400>  705


Met Asn Leu Tyr Glu Ser Phe Ala Gln Ala Thr Gln Leu Gly Asp Leu 
1               5                   10                  15      


His Thr Cys Leu Met Met Asp Met Lys Ala Cys Gln Glu Asp Asp Val 
            20                  25                  30          


Arg Leu Leu Cys His Leu Thr Pro Ser Ile Tyr Thr Glu Phe Pro Asp 
        35                  40                  45              


Glu Thr Leu Arg Ser Gly Glu Leu Leu Asn Met Ile Val Ala Val Ile 
    50                  55                  60                  


Asp Ser Ala Gln Leu Gln Glu Leu Val Cys His Val Met Met Gly Asn 
65                  70                  75                  80  


Leu Val Met Phe Arg Lys Asp Ser Val Leu Asn Ile Leu Ile Gln Ser 
                85                  90                  95      


Leu Asp Trp Glu Thr Phe Glu Gln Tyr Cys Ala Trp Gln Leu Phe Leu 
            100                 105                 110         


Ala His Asn Ile Pro Leu Glu Thr Ile Ile Pro Ile Leu Gln His Leu 
        115                 120                 125             


Lys Tyr Lys Glu His Pro Glu Ala Leu Ser Cys Leu Leu Leu Gln Leu 
    130                 135                 140                 


Arg Arg Glu Lys Pro Ser Glu Glu Met Val Lys Met Val Leu Ser Arg 
145                 150                 155                 160 


Pro Cys His Pro Asp Asp Gln Phe Thr Thr Ser Ile Leu Arg His Trp 
                165                 170                 175     


Cys Met Lys His Asp Glu Leu Leu Ala Glu His Ile Lys Ser Leu Leu 
            180                 185                 190         


Ile Lys Asn Asn Ser Leu Pro Arg Lys Arg Gln Ser Leu Arg Ser Ser 
        195                 200                 205             


Ser Ser Lys Leu Ala Gln Leu Thr Leu Glu Gln Ile Leu Glu His Leu 
    210                 215                 220                 


Asp Asn Leu Arg Leu Asn Leu Thr Asn Thr Lys Gln Asn Cys Met Pro 
225                 230                 235                 240 


Ser Thr Leu Gly Val Gln Cys Arg Arg Cys Cys Pro Gly Pro Asp Tyr 
                245                 250                 255     


Ala Trp Ser Gln Ala Gly Gly Arg Gly Arg Thr Pro Gly Ala Thr Thr 
            260                 265                 270         


His Thr Arg Asp Lys Thr Thr Cys Ala Cys Cys Leu Ile Ser Ser Gln 
        275                 280                 285             


Thr Ser Asp Cys Phe Ser Phe Pro Ala Leu Pro Phe Leu Pro Leu Val 
    290                 295                 300                 


Phe Ser Gln Thr Pro Ile Leu Gln Ala Leu Gln His Val Gln Ala Ser 
305                 310                 315                 320 


Cys Asp Glu Ala His Lys Met Lys Phe Ser Asp Leu Phe Ser Leu Ala 
                325                 330                 335     


Glu Glu Tyr Glu Asp Ser Ser Thr Lys Pro Pro Lys Ser Arg Arg Lys 
            340                 345                 350         


Ala Ala Leu Ser Ser Pro Arg Ser Arg Lys Asn Ala Thr Gln Pro Pro 
        355                 360                 365             


Asn Ala Glu Glu Glu Ser Gly Ser Ser Ser Ala Ser Glu Glu Glu Asp 
    370                 375                 380                 


Thr Lys Pro Lys Pro Thr Lys Arg Lys Arg Lys Gly Ser Ser Ala Val 
385                 390                 395                 400 


Gly Ser Asp Ser Asp 
                405 

<210>  706
<211>  1349
<212>  DNA
<213>  Homo sapiens

<400>  706
aaagggaggg gcctctgtcg tgacccctca gaaatctggc agtctgggtt tccacctttc     60

ccctatttaa ctctcagccc ccacccatcc cctggggttg cggctggcag gccgggactt    120

gcagaaccaa atgggccagg ggccaagttc attcttttgg gagagagcaa tggtaccttc    180

ccttaacggg aaaacgagaa atattgaggg gaagatggac tgcgatccaa acgccctggc    240

tctcaggcct ggactctagg gcttagccag atgcctaaac cgcccaagcc gagaaacaac    300

ttagaagaca gacataaccc tgggattcag ggaaggcgcg agcaccgccc aggacctggt    360

agggtgcgag ccgcgagcag tccgggaggg agcgcgccta gggcggagcg taggctgtgg    420

ggggagggct gggagtccgg ggccgcccca cacccgcact cctcccgggt ttctgctctc    480

cgcccgtgtg gagtggtggg ggcctgggtg ggaatgggcg tgtgccagcg cacgcgcgct    540

ccctggaagg agaagtctca gctagaacga gcggccctag gttttcggaa gggaggatca    600

gggatgtttg cgagcggctg gaaccagacg gtgccgatag aggaagcggg ctccatggct    660

gccgggggct gcagcctggc ctggcgcctc gcggaactgg cccagcagcg cgccgcgcac    720

acctttctca ttcacggctc gcggcgcttt agctactcag aggcggagcg cgagagtaac    780

agggctgcac gcgccttcct acgtgcgcta ggctgggact ggggacccga cggcggcgac    840

agcggcgagg ggagcgctgg agaaggcgag cgggcagcgc cgggagccgg agatgcagcg    900

gccggaagcg gcgcggagtt tgccggaggg gacggtgccg ccagaggtgg aggagccgcc    960

gcccctctgt cacctggagc aactgtggcg ctgctcctcc ccgctggccc agagtttctg   1020

tggctctggt tcgggctggc caaggccggc ctgcgcactg cctttgtgcc caccgccctg   1080

cgccggggcc ccctgctgca ctgcctccgc agctgcggcg cgcgcgcgct ggtgctggcg   1140

ccaggtaagg ctggagctcc gaactgacta aggcggggcc agccacagaa gggggcgtgt   1200

cggagaccac agaaaggctt ggtctcatcc ctgggcctgg gaagaagccg actatccctt   1260

ggggttcgaa agtgggtgga gataggagtc tccgggtttg agaagggatg aggctgaatc   1320

tttggtgccc caaggatccc caaggagtc                                     1349


<210>  707
<211>  298
<212>  PRT
<213>  Homo sapiens

<400>  707


Met Pro Lys Pro Pro Lys Pro Arg Asn Asn Leu Glu Asp Arg His Asn 
1               5                   10                  15      


Pro Gly Ile Gln Gly Arg Arg Glu His Arg Pro Gly Pro Gly Arg Val 
            20                  25                  30          


Arg Ala Ala Ser Ser Pro Gly Gly Ser Ala Pro Arg Ala Glu Arg Arg 
        35                  40                  45              


Leu Trp Gly Glu Gly Trp Glu Ser Gly Ala Ala Pro His Pro His Ser 
    50                  55                  60                  


Ser Arg Val Ser Ala Leu Arg Pro Cys Gly Val Val Gly Ala Trp Val 
65                  70                  75                  80  


Gly Met Gly Val Cys Gln Arg Thr Arg Ala Pro Trp Lys Glu Lys Ser 
                85                  90                  95      


Gln Leu Glu Arg Ala Ala Leu Gly Phe Arg Lys Gly Gly Ser Gly Met 
            100                 105                 110         


Phe Ala Ser Gly Trp Asn Gln Thr Val Pro Ile Glu Glu Ala Gly Ser 
        115                 120                 125             


Met Ala Ala Gly Gly Cys Ser Leu Ala Trp Arg Leu Ala Glu Leu Ala 
    130                 135                 140                 


Gln Gln Arg Ala Ala His Thr Phe Leu Ile His Gly Ser Arg Arg Phe 
145                 150                 155                 160 


Ser Tyr Ser Glu Ala Glu Arg Glu Ser Asn Arg Ala Ala Arg Ala Phe 
                165                 170                 175     


Leu Arg Ala Leu Gly Trp Asp Trp Gly Pro Asp Gly Gly Asp Ser Gly 
            180                 185                 190         


Glu Gly Ser Ala Gly Glu Gly Glu Arg Ala Ala Pro Gly Ala Gly Asp 
        195                 200                 205             


Ala Ala Ala Gly Ser Gly Ala Glu Phe Ala Gly Gly Asp Gly Ala Ala 
    210                 215                 220                 


Arg Gly Gly Gly Ala Ala Ala Pro Leu Ser Pro Gly Ala Thr Val Ala 
225                 230                 235                 240 


Leu Leu Leu Pro Ala Gly Pro Glu Phe Leu Trp Leu Trp Phe Gly Leu 
                245                 250                 255     


Ala Lys Ala Gly Leu Arg Thr Ala Phe Val Pro Thr Ala Leu Arg Arg 
            260                 265                 270         


Gly Pro Leu Leu His Cys Leu Arg Ser Cys Gly Ala Arg Ala Leu Val 
        275                 280                 285             


Leu Ala Pro Gly Lys Ala Gly Ala Pro Asn 
    290                 295             

<210>  708
<211>  4980
<212>  DNA
<213>  Homo sapiens

<400>  708
aaagggaggg gcctctgtcg tgacccctca gaaatctggc agtctgggtt tccacctttc     60

ccctatttaa ctctcagccc ccacccatcc cctggggttg cggctggcag gccgggactt    120

gcagaaccaa atgggccagg ggccaagttc attcttttgg gagagagcaa tggtaccttc    180

ccttaacggg aaaacgagaa atattgaggg gaagatggac tgcgatccaa acgccctggc    240

tctcaggcct ggactctagg gcttagccag atgcctaaac cgcccaagcc gagaaacaac    300

ttagaagaca gacataaccc tgggattcag ggaaggcgcg agcaccgccc aggacctggt    360

agggtgcgag ccgcgagcag tccgggaggg agcgcgccta gggcggagcg taggctgtgg    420

ggggagggct gggagtccgg ggccgcccca cacccgcact cctcccgggt ttctgctctc    480

cgcccgtgtg gagtggtggg ggcctgggtg ggaatgggcg tgtgccagcg cacgcgcgct    540

ccctggaagg agaagtctca gctagaacga gcggccctag gttttcggaa gggaggatca    600

gggatgtttg cgagcggctg gaaccagacg gtgccgatag aggaagcggg ctccatggct    660

gccctcctgc tgctgcccct gctgctgttg ctaccgctgc tgctgctgaa gctacacctc    720

tggccgcagt tgcgctggct tccggcggac ttggcctttg cggtgcgagc tctgtgctgc    780

aaaagggctc ttcgagctcg cgccctggcc gcggctgccg ccgacccgga aggtcccgag    840

gggggctgca gcctggcctg gcgcctcgcg gaactggccc agcagcgcgc cgcgcacacc    900

tttctcattc acggctcgcg gcgctttagc tactcagagg cggagcgcga gagtaacagg    960

gctgcacgcg ccttcctacg tgcgctaggc tgggactggg gacccgacgg cggcgacagc   1020

ggcgagggga gcgctggaga aggcgagcgg gcagcgccgg gagccggaga tgcagcggcc   1080

ggaagcggcg cggagtttgc cggaggggac ggtgccgcca gaggtggagg agccgccgcc   1140

cctctgtcac ctggagcaac tgtggcgctg ctcctccccg ctggcccaga gtttctgtgg   1200

ctctggttcg ggctggccaa ggccggcctg cgcactgcct ttgtgcccac cgccctgcgc   1260

cggggccccc tgctgcactg cctccgcagc tgcggcgcgc gcgcgctggt gctggcgcca   1320

ggtaaggctg gagctccgaa ctgactaagg cggggccagc cacagaaggg ggcgtgtcgg   1380

agaccacaga aaggcttggt ctcatccctg ggcctgggaa gaagccgact atcccttggg   1440

gttcgaaagt gggtggagat aggagtctcc gggtttgaga agggatgagg ctgaatcttt   1500

ggtgccccaa ggatccccaa ggagtcgagt tccaggcctc agacccaaga tggaatgtcc   1560

atacccttca ccctcatcca agagcagtgt gggctgggat agggagggga catgggtcat   1620

aggctcttct aggtagagcc agggccccgg cgttgtgctt tcccaccctt ctagagtttc   1680

tggagtccct ggagccggac ctgcccgccc tgagagccat ggggctccac ctgtgggctg   1740

caggcccagg aacccaccct gctggaatta gcgatttgct ggctgaagtg tccgctgaag   1800

tggatgggcc agtgccagga tacctctctt ccccccagag cataacagac acgtgcctgt   1860

acatcttcac ctctggcacc acgggcctcc ccaaggctgc tcggatcagt catctgaaga   1920

tcctgcaatg ccagggcttc tatcagctgt gtggtgtcca ccaggaagat gtgatctacc   1980

tcgccctccc actctaccac atgtccggtt ccctgctggg catcgtgggc tgcatgggca   2040

ttggtcagtc tccccaaccc caccttcatt aattcatcca gtagacattt attaagcacg   2100

tactatggtg tgagtcctcc agggtagata atctagagga cggatggggc agagccctac   2160

tcaccaggag ctctgtacaa tagggcaatg tcacctgcct agacctacag actgaggaac   2220

ggtgaggggg gccatacagc cacataactc caggctgcag ggtcaaaggc agggaaggac   2280

tgtgtcagtc caggaacagg caagtaagag aagagggaga gagagacaag gaagtgagag   2340

tgtggaggat gagatctttg gggctgggaa gtagggaaag ggcattcacc tcttctaagg   2400

ctggggacag gggccggggg aggggaaaga gggccagcac ggcttcctga cggtgtgact   2460

cccacagtgg gcccttccca gggaaagact acagtgatgg ctggggtctg gaaagagggg   2520

cttgggctcc ccactctgct cctaatctta cctcccttct tcccccctgc ccacttctgg   2580

caggggccac agtggtgctg aaatccaagt tctcggctgg tcagttctgg gaagattgcc   2640

agcagcacag ggtgacggtg ttccagtaca ttggggagct gtgccgatac cttgtcaacc   2700

agcccccggt gcgtgggcac agatcctggg cagagctgct gacacagggc tagctcacgg   2760

ggagcaggac agttgacagg agacagggag ttggagggag aagcagcaag aagaaaatgg   2820

cagtgtaaga taaggagcca gagatggcct aggccatctg atgcttacgg cctctgaagg   2880

aggtcacagt aggagggggt tctggggaat ggggaacagg aattcacttc cgggagcggg   2940

catcttgatg ctgaagctcc ggcccctctc ccactcatct cagagcaagg cagaacgtgg   3000

ccataaggtc cggctggcag tgggcagcgg gctgcgccca gatacctggg agcgttttgt   3060

gcggcgcttc gggcccctgc aggtgctgga gacatatgga ctgacagagg gcaacgtggc   3120

caccatcaac tacacaggac agcggggcgc tgtggggcgt gcttcctggc tttacaaggt   3180

gaggggcaga gaggaaactg aaaacccgtg gaacagcaga gggctggcag gagagggggc   3240

tcatgtgact gcaatgatcc agtacccagg tctccctttc cccagcatat cttccccttc   3300

tccttgattc gctatgatgt caccacagga gagccaattc gggaccccca ggggcactgt   3360

atggccacat ctccaggttg gtggtgttct ggtggggtgg gcggggtgct gaagctggca   3420

caggaggact ggaattggag actggggtgg atgggggcag aaggctctgg gaaaggtgac   3480

accactcctg accctggtga ctctgccagg tgagccaggg ctgctggtgg ccccggtaag   3540

ccagcagtcc ccattcctgg gctatgctgg cgggccagag ctggcccagg ggaagttgct   3600

aaaggatgtc ttccggcctg gggatgtttt cttcaacact ggggacctgc tggtctgcga   3660

tgaccaaggt tttctccgct tccatgatcg tactggagac accttcaggt atctgtccat   3720

aactggtttt tcatcctgga catctgatct ctgtgatcca aagcttctga acctcaactc   3780

tctaatctgc cacctcaacc tgggtcctaa gctaatctct cattctcaga tctcaccatt   3840

tcatccctgt gacactgacc tctgacctca tctccccacc aagcccataa ggccctgacc   3900

cctgactccc agtttcagat ctctgctctc tgacaggtgg aagggggaga atgtggccac   3960

aaccgaggtg gcagaggtct tcgaggccct agattttctt caggaggtga acgtctatgg   4020

agtcactgtg ccaggtgcct aggcatggaa ggtgggggag gcacccagcc accaccccga   4080

attggtagta cttgggcgca gggagcacga ggccttcgtg gtggtcagcc atggaggggc   4140

ttactctgtc tcccacaccc accagggcat gaaggcaggg ctggaatggc agccctagtt   4200

ctgcgtcccc cccacgcttt ggaccttatg cagctctaca cccacgtgtc tgagaacttg   4260

ccaccttatg cccggccccg attcctcagg ctccaggtaa ccggccactt cccccgccgg   4320

cccctcaccc catatatcct caccccacat atccaccccg tgtatcaact taggagtttg   4380

atggctccca aactccacaa agggaccccc aacgtaatac actccgtgaa gagaaaaaac   4440

acggagacac aagctcttca ccccacttct ttccttatcc ctgccttctt ctggcctggc   4500

tctttctcct ccctgtcacc tcctccccta aaccttgacc tcacactccc tttcccaaga   4560

cttgctcctt aacaaaattc aggcaactcc cctgaaccac gtgggcagag tccccttccc   4620

tccaaatccc tgaccctcct gtccccagga gtctttggcc accacagaga ccttcaaaca   4680

gcagaaagtt cggatggcaa atgagggctt cgaccccagc accctgtctg acccactgta   4740

cgttctggac caggctgtag gtgcctacct gcccctcaca actgcccggt acagcgccct   4800

cctggcagga aaccttcgaa tctgagaact tccacacctg aggcacctga gagaggaact   4860

ctgtggggtg ggggccgttg caggtgtact gggctgtcag ggatcttttc tataccagaa   4920

ctgcggtcac tattttgtaa taaatgtggc tggagctgat ccagctgtct ctgacctaca   4980


<210>  709
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  709


Met Gly Leu His Leu Trp Ala Ala Gly Pro Gly Thr His Pro Ala Gly 
1               5                   10                  15      


Ile Ser Asp Leu Leu Ala Glu Val Ser Ala Glu Val Asp Gly Pro Val 
            20                  25                  30          


Pro Gly Tyr Leu Ser Ser Pro Gln Ser Ile Thr Asp Thr Cys Leu Tyr 
        35                  40                  45              


Ile Phe Thr Ser Gly Thr Thr Gly Leu Pro Lys Ala Ala Arg Ile Ser 
    50                  55                  60                  


His Leu Lys Ile Leu Gln Cys Gln Gly Phe Tyr Gln Leu Cys Gly Val 
65                  70                  75                  80  


His Gln Glu Asp Val Ile Tyr Leu Ala Leu Pro Leu Tyr His Met Ser 
                85                  90                  95      


Gly Ser Leu Leu Gly Ile Val Gly Cys Met Gly Ile Gly Gln Ser Pro 
            100                 105                 110         


Gln Pro His Leu His 
        115         

<210>  710
<211>  3335
<212>  DNA
<213>  Homo sapiens

<400>  710
aaagggaggg gcctctgtcg tgacccctca gaaatctggc agtctgggtt tccacctttc     60

ccctatttaa ctctcagccc ccacccatcc cctggggttg cggctggcag gccgggactt    120

gcagaaccaa atgggccagg ggccaagttc attcttttgg gagagagcaa tggtaccttc    180

ccttaacggg aaaacgagaa atattgaggg gaagatggac tgcgatccaa acgccctggc    240

tctcaggcct ggactctagg gcttagccag atgcctaaac cgcccaagcc gagaaacaac    300

ttagaagaca gacataaccc tgggattcag ggaaggcgcg agcaccgccc aggacctggt    360

agggtgcgag ccgcgagcag tccgggaggg agcgcgccta gggcggagcg taggctgtgg    420

ggggagggct gggagtccgg ggccgcccca cacccgcact cctcccgggt ttctgctctc    480

cgcccgtgtg gagtggtggg ggcctgggtg ggaatgggcg tgtgccagcg cacgcgcgct    540

ccctggaagg agaagtctca gctagaacga gcggccctag gttttcggaa gggaggatca    600

gggatgtttg cgagcggctg gaaccagacg gtgccgatag aggaagcggg ctccatggct    660

gccctcctgc tgctgcccct gctgctgttg ctaccgctgc tgctgctgaa gctacacctc    720

tggccgcagt tgcgctggct tccggcggac ttggcctttg cggtgcgagc tctgtgctgc    780

aaaagggctc ttcgagctcg cgccctggcc gcggctgccg ccgacccgga aggtcccgag    840

gggggctgca gcctggcctg gcgcctcgcg gaactggccc agcagcgcgc cgcgcacacc    900

tttctcattc acggctcgcg gcgctttagc tactcagagg cggagcgcga gagtaacagg    960

gctgcacgcg ccttcctacg tgcgctaggc tgggactggg gacccgacgg cggcgacagc   1020

ggcgagggga gcgctggaga aggcgagcgg gcagcgccgg gagccggaga tgcagcggcc   1080

ggaagcggcg cggagtttgc cggaggggac ggtgccgcca gaggtggagg agccgccgcc   1140

cctctgtcac ctggagcaac tgtggcgctg ctcctccccg ctggcccaga gtttctgtgg   1200

ctctggttcg ggctggccaa ggccggcctg cgcactgcct ttgtgcccac cgccctgcgc   1260

cggggccccc tgctgcactg cctccgcagc tgcggcgcgc gcgcgctggt gctggcgcca   1320

gagtttctgg agtccctgga gccggacctg cccgccctga gagccatggg gctccacctg   1380

tgggctgcag gcccaggaac ccaccctgct ggaattagcg atttgctggc tgaagtgtcc   1440

gctgaagtgg atgggccagt gccaggatac ctctcttccc cccagagcat aacagacacg   1500

tgcctgtaca tcttcacctc tggcaccacg ggcctcccca aggctgctcg gatcagtcat   1560

ctgaagatcc tgcaatgcca gggcttctat cagctgtgtg gtgtccacca ggaagatgtg   1620

atctacctcg ccctcccact ctaccacatg tccggttccc tgctgggcat cgtgggctgc   1680

atgggcattg agcaaggcag aacgtggcca taaggtccgg ctggcagtgg gcagcgggct   1740

gcgcccagat acctgggagc gttttgtgcg gcgcttcggg cccctgcagg tgctggagac   1800

atatggactg acagagggca acgtggccac catcaactac acaggacagc ggggcgctgt   1860

ggggcgtgct tcctggcttt acaaggtgag gggcagagag gaaactgaaa acccgtggaa   1920

cagcagaggg ctggcaggag agggggctca tgtgactgca atgatccagt acccaggtct   1980

ccctttcccc agcatatctt ccccttctcc ttgattcgct atgatgtcac cacaggagag   2040

ccaattcggg acccccaggg gcactgtatg gccacatctc caggttggtg gtgttctggt   2100

ggggtgggcg gggtgctgaa gctggcacag gaggactgga attggagact ggggtggatg   2160

ggggcagaag gctctgggaa aggtgacacc actcctgacc ctggtgactc tgccaggtga   2220

gccagggctg ctggtggccc cggtaagcca gcagtcccca ttcctgggct atgctggcgg   2280

gccagagctg gcccagggga agttgctaaa ggatgtcttc cggcctgggg atgttttctt   2340

caacactggg gacctgctgg tctgcgatga ccaaggtttt ctccgcttcc atgatcgtac   2400

tggagacacc ttcaggtatc tgtccataac tggtttttca tcctggacat ctgatctctg   2460

tgatccaaag cttctgaacc tcaactctct aatctgccac ctcaacctgg gtcctaagct   2520

aatctctcat tctcagatct caccatttca tccctgtgac actgacctct gacctcatct   2580

ccccaccaag cccataaggc cctgacccct gactcccagt ttcagatctc tgctctctga   2640

caggtggaag ggggagaatg tggccacaac cgaggtggca gaggtcttcg aggccctaga   2700

ttttcttcag gaggtgaacg tctatggagt cactgtgcca ggtgcctagg catggaaggt   2760

gggggaggca cccagccacc accccgaatt ggtagtactt gggcgcaggg agcacgaggc   2820

cttcgtggtg gtcagccatg gaggggctta ctctgtctcc cacacccacc agggcatgaa   2880

ggcagggctg gaatggcagc cctagttctg cgtccccccc acgctttgga ccttatgcag   2940

ctctacaccc acgtgtctga gaacttgcca ccttatgccc ggccccgatt cctcaggctc   3000

caggagtctt tggccaccac agagaccttc aaacagcaga aagttcggat ggcaaatgag   3060

ggcttcgacc ccagcaccct gtctgaccca ctgtacgttc tggaccaggc tgtaggtgcc   3120

tacctgcccc tcacaactgc ccggtacagc gccctcctgg caggaaacct tcgaatctga   3180

gaacttccac acctgaggca cctgagagag gaactctgtg gggtgggggc cgttgcaggt   3240

gtactgggct gtcagggatc ttttctatac cagaactgcg gtcactattt tgtaataaat   3300

gtggctggag ctgatccagc tgtctctgac ctaca                              3335


<210>  711
<211>  480
<212>  PRT
<213>  Homo sapiens

<400>  711


Met Pro Lys Pro Pro Lys Pro Arg Asn Asn Leu Glu Asp Arg His Asn 
1               5                   10                  15      


Pro Gly Ile Gln Gly Arg Arg Glu His Arg Pro Gly Pro Gly Arg Val 
            20                  25                  30          


Arg Ala Ala Ser Ser Pro Gly Gly Ser Ala Pro Arg Ala Glu Arg Arg 
        35                  40                  45              


Leu Trp Gly Glu Gly Trp Glu Ser Gly Ala Ala Pro His Pro His Ser 
    50                  55                  60                  


Ser Arg Val Ser Ala Leu Arg Pro Cys Gly Val Val Gly Ala Trp Val 
65                  70                  75                  80  


Gly Met Gly Val Cys Gln Arg Thr Arg Ala Pro Trp Lys Glu Lys Ser 
                85                  90                  95      


Gln Leu Glu Arg Ala Ala Leu Gly Phe Arg Lys Gly Gly Ser Gly Met 
            100                 105                 110         


Phe Ala Ser Gly Trp Asn Gln Thr Val Pro Ile Glu Glu Ala Gly Ser 
        115                 120                 125             


Met Ala Ala Leu Leu Leu Leu Pro Leu Leu Leu Leu Leu Pro Leu Leu 
    130                 135                 140                 


Leu Leu Lys Leu His Leu Trp Pro Gln Leu Arg Trp Leu Pro Ala Asp 
145                 150                 155                 160 


Leu Ala Phe Ala Val Arg Ala Leu Cys Cys Lys Arg Ala Leu Arg Ala 
                165                 170                 175     


Arg Ala Leu Ala Ala Ala Ala Ala Asp Pro Glu Gly Pro Glu Gly Gly 
            180                 185                 190         


Cys Ser Leu Ala Trp Arg Leu Ala Glu Leu Ala Gln Gln Arg Ala Ala 
        195                 200                 205             


His Thr Phe Leu Ile His Gly Ser Arg Arg Phe Ser Tyr Ser Glu Ala 
    210                 215                 220                 


Glu Arg Glu Ser Asn Arg Ala Ala Arg Ala Phe Leu Arg Ala Leu Gly 
225                 230                 235                 240 


Trp Asp Trp Gly Pro Asp Gly Gly Asp Ser Gly Glu Gly Ser Ala Gly 
                245                 250                 255     


Glu Gly Glu Arg Ala Ala Pro Gly Ala Gly Asp Ala Ala Ala Gly Ser 
            260                 265                 270         


Gly Ala Glu Phe Ala Gly Gly Asp Gly Ala Ala Arg Gly Gly Gly Ala 
        275                 280                 285             


Ala Ala Pro Leu Ser Pro Gly Ala Thr Val Ala Leu Leu Leu Pro Ala 
    290                 295                 300                 


Gly Pro Glu Phe Leu Trp Leu Trp Phe Gly Leu Ala Lys Ala Gly Leu 
305                 310                 315                 320 


Arg Thr Ala Phe Val Pro Thr Ala Leu Arg Arg Gly Pro Leu Leu His 
                325                 330                 335     


Cys Leu Arg Ser Cys Gly Ala Arg Ala Leu Val Leu Ala Pro Glu Phe 
            340                 345                 350         


Leu Glu Ser Leu Glu Pro Asp Leu Pro Ala Leu Arg Ala Met Gly Leu 
        355                 360                 365             


His Leu Trp Ala Ala Gly Pro Gly Thr His Pro Ala Gly Ile Ser Asp 
    370                 375                 380                 


Leu Leu Ala Glu Val Ser Ala Glu Val Asp Gly Pro Val Pro Gly Tyr 
385                 390                 395                 400 


Leu Ser Ser Pro Gln Ser Ile Thr Asp Thr Cys Leu Tyr Ile Phe Thr 
                405                 410                 415     


Ser Gly Thr Thr Gly Leu Pro Lys Ala Ala Arg Ile Ser His Leu Lys 
            420                 425                 430         


Ile Leu Gln Cys Gln Gly Phe Tyr Gln Leu Cys Gly Val His Gln Glu 
        435                 440                 445             


Asp Val Ile Tyr Leu Ala Leu Pro Leu Tyr His Met Ser Gly Ser Leu 
    450                 455                 460                 


Leu Gly Ile Val Gly Cys Met Gly Ile Glu Gln Gly Arg Thr Trp Pro 
465                 470                 475                 480 

<210>  712
<211>  2304
<212>  DNA
<213>  Homo sapiens

<400>  712
aaagggaggg gcctctgtcg tgacccctca gaaatctggc agtctgggtt tccacctttc     60

ccctatttaa ctctcagccc ccacccatcc cctggggttg cggctggcag gccgggactt    120

gcagaaccaa atgggccagg ggccaagttc attcttttgg gagagagcaa tggtaccttc    180

ccttaacggg aaaacgagaa atattgaggg gaagatggac tgcgatccaa acgccctggc    240

tctcaggcct ggactctagg gcttagccag atgcctaaac cgcccaagcc gagaaacaac    300

ttagaagaca gacataaccc tgggattcag ggaaggcgcg agcaccgccc aggacctggt    360

agggtgcgag ccgcgagcag tccgggaggg agcgcgccta gggcggagcg taggctgtgg    420

ggggagggct gggagtccgg ggccgcccca cacccgcact cctcccgggt ttctgctctc    480

cgcccgtgtg gagtggtggg ggcctgggtg ggaatgggcg tgtgccagcg cacgcgcgct    540

ccctggaagg agaagtctca gctagaacga gcggccctag gttttcggaa gggaggatca    600

gggatgtttg cgagcgccgc cgcccctctg tcacctggag caactgtggc gctgctcctc    660

cccgctggcc cagagtttct gtggctctgg ttcgggctgg ccaaggccgg cctgcgcact    720

gcctttgtgc ccaccgccct gcgccggggc cccctgctgc actgcctccg cagctgcggc    780

gcgcgcgcgc tggtgctggc gccagagttt ctggagtccc tggagccgga cctgcccgcc    840

ctgagagcca tggggctcca cctgtgggct gcaggcccag gaacccaccc tgctggaatt    900

agcgatttgc tggctgaagt gtccgctgaa gtggatgggc cagtgccagg atacctctct    960

tccccccaga gcataacaga cacgtgcctg tacatcttca cctctggcac cacgggcctc   1020

cccaaggctg ctcggatcag tcatctgaag atcctgcaat gccagggctt ctatcagctg   1080

tgtggtgtcc accaggaaga tgtgatctac ctcgccctcc cactctacca catgtccggt   1140

tccctgctgg gcatcgtggg ctgcatgggc attggggcca cagtggtgct gaaatccaag   1200

ttctcggctg gtcagttctg ggaagattgc cagcagcaca gggtgacggt gttccagtac   1260

attggggagc tgtgccgata ccttgtcaac cagcccccga gcaaggcaga acgtggccat   1320

aaggtccggc tggcagtggg cagcgggctg cgcccagata cctgggagcg ttttgtgcgg   1380

cgcttcgggc ccctgcaggt gctggagaca tatggactga cagagggcaa cgtggccacc   1440

atcaactaca caggacagcg gggcgctgtg gggcgtgctt cctggcttta caaggagagc   1500

caattcggga cccccagggg cactgtatgg ccacatctcc aggtgagcca gggctgctgg   1560

tggccccggt aagccagcag tccccattcc tgggctatgc tggcgggcca gagctggccc   1620

aggggaagtt gctaaaggat gtcttccggc ctggggatgt tttcttcaac actggggacc   1680

tgctggtctg cgatgaccaa ggttttctcc gcttccatga tcgtactgga gacaccttca   1740

ggtggaaggg ggagaatgtg gccacaaccg aggtggcaga ggtcttcgag gccctagatt   1800

ttcttcagga ggtgaacgtc tatggagtca ctgtgccagg gcatgaaggc agggctggaa   1860

tggcagccct agttctgcgt cccccccacg ctttggacct tatgcagctc tacacccacg   1920

tgtctgagaa cttgccacct tatgcccggc cccgattcct caggctccag gagtctttgg   1980

ccaccacaga gaccttcaaa cagcagaaag ttcggatggc aaatgagggc ttcgacccca   2040

gcaccctgtc tgacccactg tacgttctgg accaggctgt aggtgcctac ctgcccctca   2100

caactgcccg gtacagcgcc ctcctggcag gaaaccttcg aatctgagaa cttccacacc   2160

tgaggcacct gagagaggaa ctctgtgggg tgggggccgt tgcaggtgta ctgggctgtc   2220

agggatcttt tctataccag aactgcggtc actattttgt aataaatgtg gctggagctg   2280

atccagctgt ctctgaccta cagt                                          2304


<210>  713
<211>  433
<212>  PRT
<213>  Homo sapiens

<400>  713


Met Pro Lys Pro Pro Lys Pro Arg Asn Asn Leu Glu Asp Arg His Asn 
1               5                   10                  15      


Pro Gly Ile Gln Gly Arg Arg Glu His Arg Pro Gly Pro Gly Arg Val 
            20                  25                  30          


Arg Ala Ala Ser Ser Pro Gly Gly Ser Ala Pro Arg Ala Glu Arg Arg 
        35                  40                  45              


Leu Trp Gly Glu Gly Trp Glu Ser Gly Ala Ala Pro His Pro His Ser 
    50                  55                  60                  


Ser Arg Val Ser Ala Leu Arg Pro Cys Gly Val Val Gly Ala Trp Val 
65                  70                  75                  80  


Gly Met Gly Val Cys Gln Arg Thr Arg Ala Pro Trp Lys Glu Lys Ser 
                85                  90                  95      


Gln Leu Glu Arg Ala Ala Leu Gly Phe Arg Lys Gly Gly Ser Gly Met 
            100                 105                 110         


Phe Ala Ser Ala Ala Ala Pro Leu Ser Pro Gly Ala Thr Val Ala Leu 
        115                 120                 125             


Leu Leu Pro Ala Gly Pro Glu Phe Leu Trp Leu Trp Phe Gly Leu Ala 
    130                 135                 140                 


Lys Ala Gly Leu Arg Thr Ala Phe Val Pro Thr Ala Leu Arg Arg Gly 
145                 150                 155                 160 


Pro Leu Leu His Cys Leu Arg Ser Cys Gly Ala Arg Ala Leu Val Leu 
                165                 170                 175     


Ala Pro Glu Phe Leu Glu Ser Leu Glu Pro Asp Leu Pro Ala Leu Arg 
            180                 185                 190         


Ala Met Gly Leu His Leu Trp Ala Ala Gly Pro Gly Thr His Pro Ala 
        195                 200                 205             


Gly Ile Ser Asp Leu Leu Ala Glu Val Ser Ala Glu Val Asp Gly Pro 
    210                 215                 220                 


Val Pro Gly Tyr Leu Ser Ser Pro Gln Ser Ile Thr Asp Thr Cys Leu 
225                 230                 235                 240 


Tyr Ile Phe Thr Ser Gly Thr Thr Gly Leu Pro Lys Ala Ala Arg Ile 
                245                 250                 255     


Ser His Leu Lys Ile Leu Gln Cys Gln Gly Phe Tyr Gln Leu Cys Gly 
            260                 265                 270         


Val His Gln Glu Asp Val Ile Tyr Leu Ala Leu Pro Leu Tyr His Met 
        275                 280                 285             


Ser Gly Ser Leu Leu Gly Ile Val Gly Cys Met Gly Ile Gly Ala Thr 
    290                 295                 300                 


Val Val Leu Lys Ser Lys Phe Ser Ala Gly Gln Phe Trp Glu Asp Cys 
305                 310                 315                 320 


Gln Gln His Arg Val Thr Val Phe Gln Tyr Ile Gly Glu Leu Cys Arg 
                325                 330                 335     


Tyr Leu Val Asn Gln Pro Pro Ser Lys Ala Glu Arg Gly His Lys Val 
            340                 345                 350         


Arg Leu Ala Val Gly Ser Gly Leu Arg Pro Asp Thr Trp Glu Arg Phe 
        355                 360                 365             


Val Arg Arg Phe Gly Pro Leu Gln Val Leu Glu Thr Tyr Gly Leu Thr 
    370                 375                 380                 


Glu Gly Asn Val Ala Thr Ile Asn Tyr Thr Gly Gln Arg Gly Ala Val 
385                 390                 395                 400 


Gly Arg Ala Ser Trp Leu Tyr Lys Glu Ser Gln Phe Gly Thr Pro Arg 
                405                 410                 415     


Gly Thr Val Trp Pro His Leu Gln Val Ser Gln Gly Cys Trp Trp Pro 
            420                 425                 430         


Arg 
    

<210>  714
<211>  2002
<212>  DNA
<213>  Homo sapiens

<400>  714
caccttcatt aattcatcca gtagacattt attaagcacg tactatggtg tgagtcctcc     60

agggtagata atctagagga cggatggggc agagccctac tcaccaggag ctctgtacaa    120

tagggcaatg tcacctgcct agacctacag actgaggaac ggtgaggggg gccatacagc    180

cacataactc caggctgcag ggtcaaaggc agggaaggac tgtgtcagtc caggaacagg    240

caagtaagag aagagggaga gagagacaag gaagtgagag tgtggaggat gagatctttg    300

gggctgggaa gtagggaaag ggcattcacc tcttctaagg ctggggacag gggccggggg    360

aggggaaaga gggccagcac ggcttcctga cggtgtgact cccacagtgg gcccttccca    420

gggaaagact acagtgatgg ctggggtctg gaaagagggg cttgggctcc ccactctgct    480

cctaatctta cctcccttct tcccccctgc ccacttctgg caggggccac agtggtgctg    540

aaatccaagt tctcggctgg tcagttctgg gaagattgcc agcagcacag ggtgacggtg    600

ttccagtaca ttggggagct gtgccgatac cttgtcaacc agcccccggt gcgtgggcac    660

agatcctggg cagagctgct gacacagggc tagctcacgg ggagcaggac agttgacagg    720

agacagggag ttggagggag aagcagcaag aagaaaatgg cagtgtaaga taaggagcca    780

gagatggcct aggccatctg atgcttacgg cctctgaagg aggtcacagt aggagggggt    840

tctggggaat ggggaacagg aattcacttc cgggagcggg catcttgatg ctgaagctcc    900

ggcccctctc ccactcatct cagagcaagg cagaacgtgg ccataaggtc cggctggcag    960

tgggcagcgg gctgcgccca gatacctggg agcgttttgt gcggcgcttc gggcccctgc   1020

aggtgctgga gacatatgga ctgacagagg gcaacgtggc caccatcaac tacacaggac   1080

agcggggcgc tgtggggcgt gcttcctggc tttacaagca tatcttcccc ttctccttga   1140

ttcgctatga tgtcaccaca ggagagccaa ttcgggaccc ccaggggcac tgtatggcca   1200

catctccagg ttggtggtgt tctggtgggg tgggcggggt gctgaagctg gcacaggagg   1260

actggaattg gagactgggg tggatggggg cagaaggctc tgggaaaggt gacaccactc   1320

ctgaccctgg tgactctgcc aggtgagcca gggctgctgg tggccccggt aagccagcag   1380

tccccattcc tgggctatgc tggcgggcca gagctggccc aggggaagtt gctaaaggat   1440

gtcttccggc ctggggatgt tttcttcaac actggggacc tgctggtctg cgatgaccaa   1500

ggttttctcc gcttccatga tcgtactgga gacaccttca ggtatctgtc cataactggt   1560

ttttcatcct ggacatctga tctctgtgat ccaaagcttc tgaacctcaa ctctctaatc   1620

tgccacctca acctgggtcc taagctaatc tctcattctc agatctcacc atttcatccc   1680

tgtgacactg acctctgacc tcatctcccc accaagccca taaggccctg acccctgact   1740

cccagtttca gatctctgct ctctgacagg tggaaggggg agaatgtggc cacaaccgag   1800

gtggcagagg tcttcgaggc cctagatttt cttcaggagg tgaacgtcta tggagtcact   1860

gtgccaggtg cctaggcatg gaaggtgggg gaggcaccca gccaccaccc cgaattggta   1920

gtacttgggc gcagggagca cgaggccttc gtggtggtca gccatggagg ggcttactct   1980

gtctcccaca cccaccaggg ca                                            2002


<210>  715
<211>  181
<212>  PRT
<213>  Homo sapiens

<400>  715


Met Leu Thr Ala Ser Glu Gly Gly His Ser Arg Arg Gly Phe Trp Gly 
1               5                   10                  15      


Met Gly Asn Arg Asn Ser Leu Pro Gly Ala Gly Ile Leu Met Leu Lys 
            20                  25                  30          


Leu Arg Pro Leu Ser His Ser Ser Gln Ser Lys Ala Glu Arg Gly His 
        35                  40                  45              


Lys Val Arg Leu Ala Val Gly Ser Gly Leu Arg Pro Asp Thr Trp Glu 
    50                  55                  60                  


Arg Phe Val Arg Arg Phe Gly Pro Leu Gln Val Leu Glu Thr Tyr Gly 
65                  70                  75                  80  


Leu Thr Glu Gly Asn Val Ala Thr Ile Asn Tyr Thr Gly Gln Arg Gly 
                85                  90                  95      


Ala Val Gly Arg Ala Ser Trp Leu Tyr Lys His Ile Phe Pro Phe Ser 
            100                 105                 110         


Leu Ile Arg Tyr Asp Val Thr Thr Gly Glu Pro Ile Arg Asp Pro Gln 
        115                 120                 125             


Gly His Cys Met Ala Thr Ser Pro Gly Trp Trp Cys Ser Gly Gly Val 
    130                 135                 140                 


Gly Gly Val Leu Lys Leu Ala Gln Glu Asp Trp Asn Trp Arg Leu Gly 
145                 150                 155                 160 


Trp Met Gly Ala Glu Gly Ser Gly Lys Gly Asp Thr Thr Pro Asp Pro 
                165                 170                 175     


Gly Asp Ser Ala Arg 
            180     

<210>  716
<211>  1662
<212>  DNA
<213>  Homo sapiens

<400>  716
gacaggggcc gggggagggg aaagagggcc agcacggctt cctgacggtg tgactcccac     60

agtgggccct tcccagggaa agactacagt gatggctggg gtctggaaag aggggcttgg    120

gctccccact ctgctcctaa tcttacctcc cttcttcccc cctgcccact tctggcaggg    180

gccacagtgg tgctgaaatc caagttctcg gctggtcagt tctgggaaga ttgccagcag    240

cacagggtga cggtgttcca gtacattggg gagctgtgcc gataccttgt caaccagccc    300

ccggtgcgtg ggcacagatc ctgggcagag ctgctgacac agggctagct cacggggagc    360

aggacagttg acaggagaca gggagttgga gggagaagca gcaagaagaa aatggcagtg    420

taagataagg agccagagat ggcctaggcc atctgatgct tacggcctct gaaggaggtc    480

acagtaggag ggggttctgg ggaatgggga acaggaattc acttccggga gcgggcatct    540

tgatgctgaa gctccggccc ctctcccact catctcagag caaggcagaa cgtggccata    600

aggtccggct ggcagtgggc agcgggctgc gcccagatac ctgggagcgt tttgtgcggc    660

gcttcgggcc cctgcaggtg ctggagacat atggactgac agagggcaac gtggccacca    720

tcaactacac aggacagcgg ggcgctgtgg ggcgtgcttc ctggctttac aaggtgaggg    780

gcagagagga aactgaaaac ccgtggaaca gcagagggct ggcaggagag ggggctcatg    840

tgactgcaat gatccagtac ccaggtctcc ctttccccag catatcttcc ccttctcctt    900

gattcgctat gatgtcacca caggagagcc aattcgggac ccccaggggc actgtatggc    960

cacatctcca ggtgagccag gggaagttgc taaaggatgt cttccggcct ggggatgttt   1020

tcttcaacac tggggacctg ctggtctgcg atgaccaagg ttttctccgc ttccatgatc   1080

gtactggaga caccttcagg tggaaggggg agaatgtggc cacaaccgag gtggcagagg   1140

tcttcgaggc cctagatttt cttcaggagg tgaacgtcta tggagtcact gtgccagggc   1200

atgaaggcag ggctggaatg gcagccctag ttctgcgtcc cccccacgct ttggacctta   1260

tgcagctcta cacccacgtg tctgagaact tgccacctta tgcccggccc cgattcctca   1320

ggctccagga gtctttggcc accacagaga ccttcaaaca gcagaaagtt cggatggcaa   1380

atgagggctt cgaccccagc accctgtctg acccactgta cgttctggac caggctgtag   1440

gtgcctacct gcccctcaca actgcccggt acagcgccct cctggcagga aaccttcgaa   1500

tctgagaact tccacacctg aggcacctga gagaggaact ctgtggggtg ggggccgttg   1560

caggtgtact gggctgtcag ggatcttttc tataccagaa ctgcggtcac tattttgtaa   1620

taaatgtggc tggagctgat ccagctgtct ctgacctaca gt                      1662


<210>  717
<211>  198
<212>  PRT
<213>  Homo sapiens

<400>  717


Met Met Ser Pro Gln Glu Ser Gln Phe Gly Thr Pro Arg Gly Thr Val 
1               5                   10                  15      


Trp Pro His Leu Gln Val Ser Gln Gly Lys Leu Leu Lys Asp Val Phe 
            20                  25                  30          


Arg Pro Gly Asp Val Phe Phe Asn Thr Gly Asp Leu Leu Val Cys Asp 
        35                  40                  45              


Asp Gln Gly Phe Leu Arg Phe His Asp Arg Thr Gly Asp Thr Phe Arg 
    50                  55                  60                  


Trp Lys Gly Glu Asn Val Ala Thr Thr Glu Val Ala Glu Val Phe Glu 
65                  70                  75                  80  


Ala Leu Asp Phe Leu Gln Glu Val Asn Val Tyr Gly Val Thr Val Pro 
                85                  90                  95      


Gly His Glu Gly Arg Ala Gly Met Ala Ala Leu Val Leu Arg Pro Pro 
            100                 105                 110         


His Ala Leu Asp Leu Met Gln Leu Tyr Thr His Val Ser Glu Asn Leu 
        115                 120                 125             


Pro Pro Tyr Ala Arg Pro Arg Phe Leu Arg Leu Gln Glu Ser Leu Ala 
    130                 135                 140                 


Thr Thr Glu Thr Phe Lys Gln Gln Lys Val Arg Met Ala Asn Glu Gly 
145                 150                 155                 160 


Phe Asp Pro Ser Thr Leu Ser Asp Pro Leu Tyr Val Leu Asp Gln Ala 
                165                 170                 175     


Val Gly Ala Tyr Leu Pro Leu Thr Thr Ala Arg Tyr Ser Ala Leu Leu 
            180                 185                 190         


Ala Gly Asn Leu Arg Ile 
        195             

<210>  718
<211>  1332
<212>  DNA
<213>  Homo sapiens

<400>  718
ggacagttga caggagacag ggagttggag ggagaagcag caagaagaaa atggcagtgt     60

aagataagga gccagagatg gcctaggcca tctgatgctt acggcctctg aaggaggtca    120

cagtaggagg gggttctggg gaatggggaa caggaattca cttccgggag cgggcatctt    180

gatgctgaag ctccggcccc tctcccactc atctcagagc aaggcagaac gtggccataa    240

ggtccggctg gcagtgggca gcgggctgcg cccagatacc tgggagcgtt ttgtgcggcg    300

cttcgggccc ctgcaggtgc tggagacata tggactgaca gagggcaacg tggccaccat    360

caactacaca ggacagcggg gcgctgtggg gcgtgcttcc tggctttaca aggtgagggg    420

cagagaggaa actgaaaacc cgtggaacag cagagggctg gcaggagagg gggctcatgt    480

gactgcaatg atccagtacc caggtctccc tttccccagc atatcttccc cttctccttg    540

attcgctatg atgtcaccac aggagagcca attcgggacc cccaggggca ctgtatggcc    600

acatctccag gttggtggtg ttctggtggg gtgggcgggg tgctgaagct ggcacaggag    660

gactggaatt ggagactggg gtggatgggg gcagaaggct ctgggaaagg tgacaccact    720

cctgaccctg gtgactctgc caggtgagcc agggctgctg gtggccccgg taagccagca    780

gtccccattc ctgggctatg ctggcgggcc agagctggcc caggggaagt tgctaaagga    840

tgtcttccgg cctggggatg ttttcttcaa cactggggac ctgctggtct gcgatgacca    900

aggttttctc cgcttccatg atcgtactgg agacaccttc aggtggaagg gggagaatgt    960

ggccacaacc gaggtggcag aggtcttcga ggccctagat tttcttcagg aggtgaacgt   1020

ctatggagtc actgtgccag ggcatgaagg cagggctgga atggcagccc tagttctgcg   1080

tcccccccac gctttggacc ttatgcagct ctacacccac gtgtctgaga acttgccacc   1140

ttatgcccgg ccccgattcc tcaggctcca ggtaaccggc cacttccccc gccggcccct   1200

caccccatat atcctcaccc cacatatcca ccccgtgtat caacttagga gtttgatggc   1260

tcccaaactc cacaaaggga cccccaacgt aatacactcc gtgaagagaa aaaacacgga   1320

gacacaagct ct                                                       1332


<210>  719
<211>  52
<212>  PRT
<213>  Homo sapiens

<400>  719


Met Ser Ser Gly Leu Gly Met Phe Ser Ser Thr Leu Gly Thr Cys Trp 
1               5                   10                  15      


Ser Ala Met Thr Lys Val Phe Ser Ala Ser Met Ile Val Leu Glu Thr 
            20                  25                  30          


Pro Ser Gly Gly Arg Gly Arg Met Trp Pro Gln Pro Arg Trp Gln Arg 
        35                  40                  45              


Ser Ser Arg Pro 
    50          

<210>  720
<211>  626
<212>  DNA
<213>  Homo sapiens

<400>  720
ccccaccaag cccataaggc cctgacccct gactcccagt ttcagatctc tgctctctga     60

caggtggaag ggggagaatg tggccacaac cgaggtggca gaggtcttcg aggccctaga    120

ttttcttcag gaggtgaacg tctatggagt cactgtgcca gggcatgaag gcagggctgg    180

aatggcagcc ctagttctgc gtccccccca cgctttggac cttatgcagc tctacaccca    240

cgtgtctgag aacttgccac cttatgcccg gccccgattc ctcaggctcc aggagtcttt    300

ggccaccaca gagaccttca aacagcagaa agttcggatg gcaaatgagg gcttcgaccc    360

cagcaccctg tctgacccac tgtacgttct ggaccaggct gtaggtgcct acctgcccct    420

cacaactgcc cggtacagcg ccctcctggc aggaaacctt cgaatctgag aacttccaca    480

cctgaggcac ctgagagagg aactctgtgg ggtgggggcc gttgcaggtg tactgggctg    540

tcagggatct tttctatacc agaactgcgg tcactatttt gtaataaatg tggctggagc    600

tgatccagct gtctctgacc tacagt                                         626


<210>  721
<211>  95
<212>  PRT
<213>  Homo sapiens

<400>  721


Met Ala Ala Leu Val Leu Arg Pro Pro His Ala Leu Asp Leu Met Gln 
1               5                   10                  15      


Leu Tyr Thr His Val Ser Glu Asn Leu Pro Pro Tyr Ala Arg Pro Arg 
            20                  25                  30          


Phe Leu Arg Leu Gln Glu Ser Leu Ala Thr Thr Glu Thr Phe Lys Gln 
        35                  40                  45              


Gln Lys Val Arg Met Ala Asn Glu Gly Phe Asp Pro Ser Thr Leu Ser 
    50                  55                  60                  


Asp Pro Leu Tyr Val Leu Asp Gln Ala Val Gly Ala Tyr Leu Pro Leu 
65                  70                  75                  80  


Thr Thr Ala Arg Tyr Ser Ala Leu Leu Ala Gly Asn Leu Arg Ile 
                85                  90                  95  

<210>  722
<211>  278
<212>  DNA
<213>  Homo sapiens

<400>  722
cagggctgga atggcagccc tagttctgcg tcccccccac gctttggacc aggctgtagg     60

tgcctacctg cccctcacaa ctgcccggta cagcgccctc ctggcaggaa accttcgaat    120

ctgagaactt ccacacctga ggcacctgag agaggaactc tgtggggtgg gggccgttgc    180

aggtgtactg ggctgtcagg gatcttttct ataccagaac tgcggtcact attttgtaat    240

aaatgtggct ggagctgatc cagctgtctc tgacctac                            278


<210>  723
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  723


Met Ala Ala Leu Val Leu Arg Pro Pro His Ala Leu Asp Gln Ala Val 
1               5                   10                  15      


Gly Ala Tyr Leu Pro Leu Thr Thr Ala Arg Tyr Ser Ala Leu Leu Ala 
            20                  25                  30          


Gly Asn Leu Arg Ile 
        35          

<210>  724
<211>  876
<212>  DNA
<213>  Homo sapiens

<400>  724
tgctcataat agccaaaaag tggaaacaac ccaaatgtca gtctcctgat gagcagataa     60

acaaaatgta gtctatccat gcaatggaat cttattcagg gattaaaaag aatgaagtgc    120

tgagacaggc tacaagatgg atgaaacttg aagacattac gctaagtgaa ataagccaga    180

cacgaaagga caaatatcat atgattccac tgtatatgag tactggaggc tggaaagtcc    240

aagcttgaag gtgctggcca atcccgttcc cggcgattgg gcccctccct ggcttgcaga    300

ggcctgagtt cccgtggagt caccacgcgc ctttccttgg ctgtgctgca ggctccgagc    360

tggccttcgt gcaggagctg ggggacacag tggctgtgtg ggagcaccca ctggtgctgc    420

cctgccaggt ggagggtgag ccgcctgtgt ccatttcctg gcagcgggat aggctggcct    480

tagccaatga gagtggtgtc accctgatgc cagatggctc cctgcacctg gccgccctgc    540

cttcccgccg gagcctccct tcccgtgccc acgagtacca ctgcgtggcc cagaaccgct    600

acgggcggct ggtgagccga caggcccggg tacagctggc aagtaagtga cagggctgct    660

cctgggattg ggggatgaga gttggtgggg cacccacaga aggcacccat ggggcccaga    720

ctcgctgaga gtgggcctga gcagggccag cccagccatt agacacagtg tacacactgg    780

tagagcctct gattctttta ggggcccaca aaaatgtttt aacttcttca aaaccagaag    840

aaaaaaatga atacaataat aaatatgtaa aaatga                              876


<210>  725
<211>  54
<212>  PRT
<213>  Homo sapiens

<400>  725


Met Glu Ser Tyr Ser Gly Ile Lys Lys Asn Glu Val Leu Arg Gln Ala 
1               5                   10                  15      


Thr Arg Trp Met Lys Leu Glu Asp Ile Thr Leu Ser Glu Ile Ser Gln 
            20                  25                  30          


Thr Arg Lys Asp Lys Tyr His Met Ile Pro Leu Tyr Met Ser Thr Gly 
        35                  40                  45              


Gly Trp Lys Val Gln Ala 
    50                  

<210>  726
<211>  2692
<212>  DNA
<213>  Homo sapiens

<400>  726
caggaacacg aaggcaagga cagtagcctt cagtctcgac cccagagctt ggcaccccag     60

aacctgggct ccccaaagca agaccagggc ccccacattg tgcgccaaag tgcggggtgg    120

agaatgccca cagcccaagg gcccccaggc tgaaggcagg agactggggc tgctggagaa    180

gttgcccagg ctgaggggcc gtgcctggca gggacatggg gctgctgctg ctgctgctcc    240

caggctgggg ctgtgctgca ggctccgagc tggccttcgt gcaggagctg ggggacacag    300

tggctgtgtg ggagcaccca ctggtgctgc cctgccaggt ggagggtgag ccgcctgtgt    360

ccatttcctg gcagcgggat aggctggcct tagccaatga gagtggtgtc accctgatgc    420

cagatggctc cctgcacctg gccgccctgc cttcccgccg gagcctccct tcccgtgccc    480

acgagtacca ctgcgtggcc cagaaccgct acgggcggct ggtgagccga caggcccggg    540

tacagctggc aagtctgtcc cgcttccacc aacatccaga atccattgag gtggagcggg    600

gtggagttgc tcgcttccag tgcctgatcc agggggtgcc tgagccatcc atttcctggg    660

agcacaatgg cacagccctg aatactgcca accaccgggt cacactgctg cctagtggca    720

tcctccacat caccagtgtg agccagactg acatgggaac ctaccgctgc gtggcatgga    780

atgtggccag tacccgccac agccaggatg cccagctgac cctgagtgtg ggacccctga    840

ggctgctgca ggagccagag atcctgtctg ggcctcagaa cctgaccctc acagtgcacc    900

agacggcagt gctggagtgc attgccacca gtcacccttg gccgcttgtc tcctggagcc    960

gcctggatgg ccgctccatc ggcgtagagg gcatccaagt tctggacatt ctggacacag   1020

ggaatctcat gatctccgac gtctcagtcc agcactcagg tgtctatgtc tgcgccgcca   1080

atcggccagg cacccatgtc cggcgcacag cgcagggcgt cctgctcgtg cagggtgagc   1140

cccaagggcc caactgggtg gggagagtgc tggagcaccc cagctccctg acaggagcct   1200

ggatctggag agggtccagg gcaggaggca agaggctggg tctcacggca ccttcctcca   1260

tgctattgcc tgcccagctc cccgagtttg tccagtggcc acagtccttg tccaagcctc   1320

cgggcagcag tgccatcttc acctgcgtgg cccagggcgt ccctgagtcc cgtctggtct   1380

ggctgaagaa tgggaaggtg ttgagtcctg ggaataacat caggctgact cacaacaata   1440

gtacgctgat gctggcaggg gtttcagttg aggatgaggc catctatcaa tgcgtggcag   1500

agaacagcac gggctccaac caggccagtg cccgcctggt tgtgacaggg ggcccagagc   1560

caccccgtcc ccaggggcct gcatgccatg gctctctcta cttctgccat tcgagtgtcc   1620

tgggagccac ccccccctcc agcagggaca tcattggcta cgtgctgcac ctccggcctg   1680

tgggagagcc atctggcccg gagctccaag aggccataag caaaggcact tctgagcacg   1740

tcttctccaa cctggagcct gccacagcct acaccatcca tttgcgggcc tactcagcag   1800

agggtgccag tcaggactct gctcccatct ttgcctccac catgggcagc acccctgctg   1860

ccctgggctt ctccaccaaa gtgctgaatg ccacctctgg gcctctgctc ctggccagca   1920

gtgtcagctc cttcctctac acagacctgg aaccggctgc tctctatgac atcaagctgc   1980

aggcgttcaa tggcaatggg gatggaaata gcagtgcccg ctgtgtctca ttgtgtgatg   2040

tgcccctggc cactcctgat ggcacagtgt ccacagagtc caagactggg tgctcttgca   2100

gccagggtga gagcagccca ctgcctgggg ttgtggtggg catccacgtg ggcctggctg   2160

ccctcatcat ttgcctcctc tgcctcttcc tgggctggag acatagctaa gggccaggta   2220

agggctaatg tgggaaatct gccagggaga cagtctgcat cactgtggca cagggccaaa   2280

gagagcaaaa aagccccaat ctacaaccaa tcaattttac caatgaggag actcaggcag   2340

agagaggaag ccaattcttt tcagagctgt gtggtaccag gggcaggaga aggcctgcca   2400

tgagccggga agagagaact ggggctccca aagcaaagaa caagggcagc agaaatgagc   2460

tagagccagt tccctgccat ccagcagcat gaagaggggt ccaccctctc catctctggg   2520

gagcatggag caggaggagg ggttgggagc catgcgaggc agagggaggc accagacaga   2580

ccacactgct gacccttcct acccgggcag cctcctctgc aaacaggagt cccaggaatg   2640

ctgggcagtg cctcggactg cctcggacag aactgggggc catcaaggcc ag           2692


<210>  727
<211>  664
<212>  PRT
<213>  Homo sapiens

<400>  727


Met Gly Leu Leu Leu Leu Leu Leu Pro Gly Trp Gly Cys Ala Ala Gly 
1               5                   10                  15      


Ser Glu Leu Ala Phe Val Gln Glu Leu Gly Asp Thr Val Ala Val Trp 
            20                  25                  30          


Glu His Pro Leu Val Leu Pro Cys Gln Val Glu Gly Glu Pro Pro Val 
        35                  40                  45              


Ser Ile Ser Trp Gln Arg Asp Arg Leu Ala Leu Ala Asn Glu Ser Gly 
    50                  55                  60                  


Val Thr Leu Met Pro Asp Gly Ser Leu His Leu Ala Ala Leu Pro Ser 
65                  70                  75                  80  


Arg Arg Ser Leu Pro Ser Arg Ala His Glu Tyr His Cys Val Ala Gln 
                85                  90                  95      


Asn Arg Tyr Gly Arg Leu Val Ser Arg Gln Ala Arg Val Gln Leu Ala 
            100                 105                 110         


Ser Leu Ser Arg Phe His Gln His Pro Glu Ser Ile Glu Val Glu Arg 
        115                 120                 125             


Gly Gly Val Ala Arg Phe Gln Cys Leu Ile Gln Gly Val Pro Glu Pro 
    130                 135                 140                 


Ser Ile Ser Trp Glu His Asn Gly Thr Ala Leu Asn Thr Ala Asn His 
145                 150                 155                 160 


Arg Val Thr Leu Leu Pro Ser Gly Ile Leu His Ile Thr Ser Val Ser 
                165                 170                 175     


Gln Thr Asp Met Gly Thr Tyr Arg Cys Val Ala Trp Asn Val Ala Ser 
            180                 185                 190         


Thr Arg His Ser Gln Asp Ala Gln Leu Thr Leu Ser Val Gly Pro Leu 
        195                 200                 205             


Arg Leu Leu Gln Glu Pro Glu Ile Leu Ser Gly Pro Gln Asn Leu Thr 
    210                 215                 220                 


Leu Thr Val His Gln Thr Ala Val Leu Glu Cys Ile Ala Thr Ser His 
225                 230                 235                 240 


Pro Trp Pro Leu Val Ser Trp Ser Arg Leu Asp Gly Arg Ser Ile Gly 
                245                 250                 255     


Val Glu Gly Ile Gln Val Leu Asp Ile Leu Asp Thr Gly Asn Leu Met 
            260                 265                 270         


Ile Ser Asp Val Ser Val Gln His Ser Gly Val Tyr Val Cys Ala Ala 
        275                 280                 285             


Asn Arg Pro Gly Thr His Val Arg Arg Thr Ala Gln Gly Val Leu Leu 
    290                 295                 300                 


Val Gln Gly Glu Pro Gln Gly Pro Asn Trp Val Gly Arg Val Leu Glu 
305                 310                 315                 320 


His Pro Ser Ser Leu Thr Gly Ala Trp Ile Trp Arg Gly Ser Arg Ala 
                325                 330                 335     


Gly Gly Lys Arg Leu Gly Leu Thr Ala Pro Ser Ser Met Leu Leu Pro 
            340                 345                 350         


Ala Gln Leu Pro Glu Phe Val Gln Trp Pro Gln Ser Leu Ser Lys Pro 
        355                 360                 365             


Pro Gly Ser Ser Ala Ile Phe Thr Cys Val Ala Gln Gly Val Pro Glu 
    370                 375                 380                 


Ser Arg Leu Val Trp Leu Lys Asn Gly Lys Val Leu Ser Pro Gly Asn 
385                 390                 395                 400 


Asn Ile Arg Leu Thr His Asn Asn Ser Thr Leu Met Leu Ala Gly Val 
                405                 410                 415     


Ser Val Glu Asp Glu Ala Ile Tyr Gln Cys Val Ala Glu Asn Ser Thr 
            420                 425                 430         


Gly Ser Asn Gln Ala Ser Ala Arg Leu Val Val Thr Gly Gly Pro Glu 
        435                 440                 445             


Pro Pro Arg Pro Gln Gly Pro Ala Cys His Gly Ser Leu Tyr Phe Cys 
    450                 455                 460                 


His Ser Ser Val Leu Gly Ala Thr Pro Pro Ser Ser Arg Asp Ile Ile 
465                 470                 475                 480 


Gly Tyr Val Leu His Leu Arg Pro Val Gly Glu Pro Ser Gly Pro Glu 
                485                 490                 495     


Leu Gln Glu Ala Ile Ser Lys Gly Thr Ser Glu His Val Phe Ser Asn 
            500                 505                 510         


Leu Glu Pro Ala Thr Ala Tyr Thr Ile His Leu Arg Ala Tyr Ser Ala 
        515                 520                 525             


Glu Gly Ala Ser Gln Asp Ser Ala Pro Ile Phe Ala Ser Thr Met Gly 
    530                 535                 540                 


Ser Thr Pro Ala Ala Leu Gly Phe Ser Thr Lys Val Leu Asn Ala Thr 
545                 550                 555                 560 


Ser Gly Pro Leu Leu Leu Ala Ser Ser Val Ser Ser Phe Leu Tyr Thr 
                565                 570                 575     


Asp Leu Glu Pro Ala Ala Leu Tyr Asp Ile Lys Leu Gln Ala Phe Asn 
            580                 585                 590         


Gly Asn Gly Asp Gly Asn Ser Ser Ala Arg Cys Val Ser Leu Cys Asp 
        595                 600                 605             


Val Pro Leu Ala Thr Pro Asp Gly Thr Val Ser Thr Glu Ser Lys Thr 
    610                 615                 620                 


Gly Cys Ser Cys Ser Gln Gly Glu Ser Ser Pro Leu Pro Gly Val Val 
625                 630                 635                 640 


Val Gly Ile His Val Gly Leu Ala Ala Leu Ile Ile Cys Leu Leu Cys 
                645                 650                 655     


Leu Phe Leu Gly Trp Arg His Ser 
            660                 

<210>  728
<211>  2376
<212>  DNA
<213>  Homo sapiens

<400>  728
ggagtgttag gggcagaagt tttgaatgca cttaaccgga ggagggcgca gggtgggggg     60

tatcaaagaa ggacgaatag caccctacct gtgggtgttt gggggctgga caatttgggt    120

ggcagtgttt ggtactgaag ttgggctcta agaatgaggg gaaagagcct ggggaggagc    180

ttaaaactca accactctgg aatttaccca tagaagacgg gaagaaagag gtatgaagat    240

gggctcaatt atgagccagg gaggattgaa actaggtcct gcctttctgt atcttgggga    300

aataagaccg atctcctgac cccattggga acacggaagt ctattccagg ccaaccagcc    360

caaaattatt tcatcttgta ttctttgtaa aattctccct caccccaccc tgcttttaaa    420

aattctaatc tatcccctct aaccatagcc ccatctataa tacagaggaa cggctgttcc    480

aaggctgttt gctgggtgtc ccacaagttg ggtggacata aatgagtcaa gtgacaacag    540

gaggaaatag acttagacga aagaaaggat ttctcttcca acagttgaga ttcgcatatt    600

tgcctattct ttcaccctct gagtgccagg agatgagagg ctgggggtac acaatcaggt    660

tggagtcctg tccttactct gctgcaccag ctgcagaacc aactgctcaa accaggccac    720

cttagaatgg ggtttggaag taagatgtat agagttgggg aatcatggag aaggaaagcc    780

tatagtcgag tgcctgctta ggtgctgagg tcacagggga gatggtggaa tcttccctgt    840

ttttatcccc tcagggtcag ttacatagaa gctgcttctt gactagtata gctcggtgac    900

cctttgttca accgctgagg tttgatttct taccctttct tctccccatt ttcatactct    960

tcccagggat tagtgatgga ggtgaggtct ccctaatcat ggtaaagtgt taaccttcca   1020

cctcctccct tccctcctcc ttcctcatcc ttctgtcttc ctcaattctc cgtctctttt   1080

ttttcatcac tgattgcctt gtgtccctcc aagtctactt gttactatcc atctccaggc   1140

tctgggccgt gtagacacta aacctcatgc cctaaggaca ggaggaaaga ccctctgttt   1200

ggagcattat tagtagagtg aggatcccac cagttctgcc tggcttcctc catccccaga   1260

ggcactaaaa gcagtatttt aaggttggtg tcttactccc tggaagcctg aaatgggtgg   1320

aatagcggta aggcttgagt aaaactaggg gacagaggtt cttatttgtc gattttattt   1380

tataatttga ccacagcatc tgaactccct ctctccctgg aataagtatt tttcccacat   1440

ttttggatat atgtatggta gacaattttt ttttaagaca cagagataaa tgttttcctg   1500

ctttggttac ctttcctttc ccctttaaaa ggaattagct atagaactgc tttgtaaaga   1560

tgcttcttga tattttactt ttgttccttt tccctaatca ttcccttttc tccccactcc   1620

tccagaaggc ataacccttc tctccacacc ccctaccccc acccccgtcc taggctccca   1680

tcctttccat caagaccttc attagcttat gatatttgct gccgagatgt tataacaagg   1740

actcgttcat gtatataagc tatttcttga tccatttaaa aggaattgta cattgtgtag   1800

aaaaaaaaaa aaacctgaaa aagagaaaaa aaagccctag ccatggatat tgtgaaactg   1860

tgttatgtca ttttgtaatg tgcccgtttg tgtatgatcc gtgcaaaagg gtttctgggg   1920

aaggggaggg ggtagggagg cagggctgtg gagggtgggt aggggagtgg gccgggccca   1980

gcacactgag actggcagct gctccaaccc catccctcct tagagatgcc acctccccca   2040

ccacccaccc ctaatttgtg ccttgcctcc ccaccctgga gtagtccctc cgggtcacca   2100

gcactgcctt ggcagagccc actccctacc ctaacctgcc caccctccct atcccccagc   2160

attaggttga tactgtgggg aagtgctggg ggctgggagg tagccgagga atggggcagt   2220

tcccgggggc atcgaaacca agtattatta tgaattgtaa ttgtatttgc actgtttttt   2280

tcctctgatt gcatcagcat atatacaata tacctatata acaaaattca gtgtcaagct   2340

ttcttatgca agggatttcc cccaccccac ctcctc                             2376


<210>  729
<211>  67
<212>  PRT
<213>  Homo sapiens

<400>  729


Met Ser Gln Val Thr Thr Gly Gly Asn Arg Leu Arg Arg Lys Lys Gly 
1               5                   10                  15      


Phe Leu Phe Gln Gln Leu Arg Phe Ala Tyr Leu Pro Ile Leu Ser Pro 
            20                  25                  30          


Ser Glu Cys Gln Glu Met Arg Gly Trp Gly Tyr Thr Ile Arg Leu Glu 
        35                  40                  45              


Ser Cys Pro Tyr Ser Ala Ala Pro Ala Ala Glu Pro Thr Ala Gln Thr 
    50                  55                  60                  


Arg Pro Pro 
65          

<210>  730
<211>  6152
<212>  DNA
<213>  Homo sapiens

<400>  730
agcgtccttg tttgtgtggt gccgccgccg ccggtgcagc cgtcgccgcc gccgctgccc     60

ccgtctgtac cgcagtgtct gctccgcccg cccgccccgg tccggcccgc ccccctcccc    120

tacccccgtc cctagtcccg tcagcagggt ctggatcccc tgtgccgtcg cctcttcctt    180

tttcgacgcc tccgccgccg cctgaggagg cgagctagcc gggagttaca ccgccaccgc    240

caggatggat agaatgacag aagatgctct tcgcttgaat ctgttgaagc ggagcttgga    300

cccagcagat gagcgagatg atgtcctggc aaagcgactc aaaatggagg ggcatgaggc    360

catggaacgt ctgaaaatgt tggcattgct caaaaggaag gatttggcaa atcttgaggt    420

gccacatgag ttacccacca aacaggatgg cagtggtgtc aagggctatg aagaaaaact    480

taacgggaat ctcaggcctc atggagacaa caggactgct ggaaggccag gcaaagaaaa    540

catcaatgat gagcctgtgg atatgagtgc tagacggagt gagccagagc gaggaaggct    600

aactccctca ccagacatca ttgttttgtc tgacaatgag gcttccagtc cccgttccag    660

ttccagaatg gaagaaagac tcaaagcagc caacttagag atgtttaagg ggaaaggcat    720

tgaggagcgg cagcagctta tcaagcagct gagggatgag ctacgattgg aagaagcccg    780

actggtcctg ttaaagaaac tgagacagag tcagctacag aaagagaatg tggtccagaa    840

gactccagtt gtacagaatg cagcatctat tgttcagcca tctcctgccc atgtgggaca    900

gcagggccta tctaagcttc cctctcggcc tggggcccaa ggggttgaac ctcaaaattt    960

gagaacatta cagggtcaca gtgtcatccg ttcagctacc aataccaccc ttccacacat   1020

gttgatgtct caacgtgtta ttgcaccaaa cccagcccag ctacagggtc agcggggccc   1080

gcctaagcct ggccttgtac gcaccacaac acccaacatg aatcccgcca tcaattatca   1140

accgcagtca agttcttctg ttccatgtca gcgtacaaca tcctctgcca tctatatgaa   1200

ccttgcttct catatccagc cagggacggt gaacagagtg tcctcgccac ttcctagccc   1260

cagcgccatg actgatgctg ccaactcaca ggctgcagcc aaattggctc ttcgcaaaca   1320

gctggaaaag acactcctgg agatcccacc ccctaaacct cctgctccct tacttcattt   1380

cttgcctagt gcagccaata gcgagttcat ctacatggta ggcttggaag aagtcgtaca   1440

gagtgtcatt gacagccaag gcaaaagctg tgcctcactt ctgcgggttg aaccctttgt   1500

atgtgcccag tgccgcacag atttcacccc tcactggaag caagaaaaga atggtaagat   1560

tctatgtgag cagtgtatga cctccaacca gaaaaaggct ctaaaagctg aacacaccaa   1620

ccggctgaaa aatgcatttg tgaaagccct acagcaggaa caggaaattg aacagcgatt   1680

acagcagcag gcagccctct cccccactac ggctccagct gtgtccagtg tcagtaaaca   1740

agagaccatc atgagacatc atacgcttcg gcaggctcca cagccccaga gcagcctcca   1800

gcgtggcata cccacatctg cccgctccat gctttcaaac tttgcacagg caccccagtt   1860

gtctgtgcca ggtggcctcc ttggtatgcc aggtgtcaac attgcatact tgaatactgg   1920

catcggagga cacaaaggcc ccagtttggc agaccgacag cgtgaatacc ttttagacat   1980

gatccctccc cggtctatat cgcagtccat cagtggacag aaataacgcc tgttccactt   2040

gtactgcccc atccttgaat cctttatccc tttcctcttt cattccccca acttctgtcg   2100

catgcagtgc ctgtactggt gcctaccata cacggaaagc aaaacagaaa aacagaagac   2160

aaaaaataga gatcagcaag aaaacacacg ccctgccctg ccacctcccc tttatttcac   2220

actgctgcga tctgttcttc tgccgctctg tcttctctct tcagttttct ttaacagtga   2280

ggtggatctt tacctctgat agaggtcaga atgaggtcct ggggagaatc taagccctcc   2340

gatgtgtgtt tctaaagttg ttttatgcta taattattac catttttaat gatgttgtgt   2400

gtcctccctt tgttcagtgg acggttaaac cttcccccac tcaaccaatc tttttctttt   2460

tccttttctt cctttttttt tttttttttt gtaaacacaa atgacattca gttcaatgat   2520

acgagcattg cagattgcag taggggtccc agctgccaag taggacatga ctaggagtgt   2580

taggggcaga agttttgaat gcacttaacc ggaggagggc gcagggtggg gggtatcaaa   2640

gaaggacgaa tagcacccta cctgtgggtg tttgggggct ggacaatttg ggtggcagtg   2700

tttggtactg aagttgggct ctaagaatga ggggaaagag cctggggagg agcttaaaac   2760

tcaaccactc tggaatttac ccatagaaga cgggaagaaa gaggtatgaa gatgggctca   2820

attatgagcc agggaggatt gaaactaggt cctgcctttc tgtatcttgg ggaaataaga   2880

ccgatctcct gaccccattg ggaacacgga agtctattcc aggccaacca gcccaaaatt   2940

atttcatctt gtattctttg taaaattctc cctcacccca ccctgctttt aaaaattcta   3000

atctatcccc tctaaccata gccccatcta taatacagag gaacggctgt tccaaggctg   3060

tttgctgggt gtcccacaag ttgggtggac ataaatgagt caagtgacaa caggaggaaa   3120

tagacttaga cgaaagaaag gatttctctt ccaacagttg agattcgcat atttgcctat   3180

tctttcaccc tctgagtgcc aggagatgag aggctggggg tacacaatca ggttggagtc   3240

ctgtccttac tctgctgcac cagctgcaga accaactgct caaagccaaa cagctcatgg   3300

caaaaccagc ttaggacctc tgctgtacaa atagttgctt cccactgccc cccgcccgcc   3360

cccagaatga tattaatttt gccttttttt tttttttttt tttaagcgct actaatgtag   3420

agaatgaatt gaattgtgca atgttgctgt tctggggact ggggagatta gcatcccatt   3480

tgcccacact gtgggaagac ggagtggacc aggctgtttt tgaagtaagg gaagcccctt   3540

aaaggtacgg gtttctgctc ttctcatagt gtacacccac ctgcctctct ggctccagaa   3600

gctgccagag tgcactgggg ggaatgttct cagcagagaa gaatgaggag aagtttaata   3660

ttttgccctt gaaagtcacc tgaggaagtt tccccacttt tattttttaa aattaagtaa   3720

ttttttaaag aaggcacttt taaaattaac acacacatga actgcacacc ttccccataa   3780

aatttggagg tggggtggga gaaagagcta aaatcaggct cagttcccct actctggcct   3840

ctactcccca caccccagtg ccactgtggg tgactatact ggccctacgg gccttcctgg   3900

cttttttctt tcctccctta ccccaaattc attgagcact taaaggagca gagatgcagc   3960

cagtgtctgg gctcccccag tggtgaaatg atctggaagc tagatgctag taacaggtag   4020

tgattgggtt ttttgagtat ttttccgggg aatgtggtac ccctgactgt aagtggtggg   4080

agagggaggg gggttaatgg aactgggtct gggattattt taaaattata tatatatata   4140

taaagatata ttcttacatc ttttctttgc cctctgtgct ttgaaagcac tggataaatt   4200

gtttggtttt gcttttctct cttccacaaa attggaagct ttttttaaaa atgttttccc   4260

cacaagtcat cttgccttgt ggcatgtctg tctagcctct tcctccctcc ctcatgatga   4320

agtgccattt ctgttacgtc tccctctccc caagctcaga ggtgctcaga ggtacgagat   4380

gcccaagttt gtcagttgag attaaaagta aggaacagag aatgtgcaat accgtctggc   4440

tgggggctgt ccctgccctg ccctgagctg agtcctttcc ctgggagcca ggccacctta   4500

gaatggggtt tggaagtaag atgtatagag ttggggaatc atggagaagg aaagcctata   4560

gtcgagtgcc tgcttaggtg ctgaggtcac aggggagatg gtggaatctt ccctgttttt   4620

atcccctcag ggtcagttac atagaagctg cttcttgact agtatagctc ggtgaccctt   4680

tgttcaaccg ctgaggtttg atttcttacc ctttcttctc cccattttca tactcttccc   4740

agggattagt gatggaggtg aggtctccct aatcatggta aagtgttaac cttccacctc   4800

ctcccttccc tcctccttcc tcatccttct gtcttcctca attctccgtc tctttttttt   4860

catcactgat tgccttgtgt ccctccaagt ctacttgtta ctatccatct ccaggctctg   4920

ggccgtgtag acactaaacc tcatgcccta aggacaggag gaaagaccct ctgtttggag   4980

cattattagt agagtgagga tcccaccagt tctgcctggc ttcctccatc cccagaggca   5040

ctaaaagcag tattttaagg ttggtgtctt actccctgga agcctgaaat gggtggaata   5100

gcggtaaggc ttgagtaaaa ctaggggaca gaggttctta tttgtcgatt ttattttata   5160

atttgaccac agcatctgaa ctccctctct ccctggaata agtatttttc ccacattttt   5220

ggatatatgt atggtagaca attttttttt aagacacaga gataaatgtt ttcctgcttt   5280

ggttaccttt cctttcccct ttaaaaggaa ttagctatag aactgctttg taaagatgct   5340

tcttgatatt ttacttttgt tccttttccc taatcattcc cttttctccc cactcctcca   5400

gaaggcataa cccttctctc cacaccccct acccccaccc ccgtcctagg ctcccatcct   5460

ttccatcaag accttcatta gcttatgata tttgctgccg agatgttata acaaggactc   5520

gttcatgtat ataagctatt tcttgatcca tttaaaagga attgtacatt gtgtagaaaa   5580

aaaaaaaaac ctgaaaaaga gaaaaaaaag ccctagccat ggatattgtg aaactgtgtt   5640

atgtcatttt gtaatgtgcc cgtttgtgta tgatccgtgc aaaagggttt ctggggaagg   5700

ggagggggta gggaggcagg gctgtggagg gtgggtaggg gagtgggccg ggcccagcac   5760

actgagactg gcagctgctc caaccccatc cctccttaga gatgccacct cccccaccac   5820

ccacccctaa tttgtgcctt gcctccccac cctggagtag tccctccggg tcaccagcac   5880

tgccttggca gagcccactc cctaccctaa cctgcccacc ctccctatcc cccagcatta   5940

ggttgatact gtggggaagt gctgggggct gggaggtagc cgaggaatgg ggcagttccc   6000

gggggcatcg aaaccaagta ttattatgaa ttgtaattgt atttgcactg tttttttcct   6060

ctgattgcat cagcatatat acaatatacc tatataacaa aattcagtgt caagctttct   6120

tatgcaaggg atttccccca ccccacctcc tc                                 6152


<210>  731
<211>  593
<212>  PRT
<213>  Homo sapiens

<400>  731


Met Asp Arg Met Thr Glu Asp Ala Leu Arg Leu Asn Leu Leu Lys Arg 
1               5                   10                  15      


Ser Leu Asp Pro Ala Asp Glu Arg Asp Asp Val Leu Ala Lys Arg Leu 
            20                  25                  30          


Lys Met Glu Gly His Glu Ala Met Glu Arg Leu Lys Met Leu Ala Leu 
        35                  40                  45              


Leu Lys Arg Lys Asp Leu Ala Asn Leu Glu Val Pro His Glu Leu Pro 
    50                  55                  60                  


Thr Lys Gln Asp Gly Ser Gly Val Lys Gly Tyr Glu Glu Lys Leu Asn 
65                  70                  75                  80  


Gly Asn Leu Arg Pro His Gly Asp Asn Arg Thr Ala Gly Arg Pro Gly 
                85                  90                  95      


Lys Glu Asn Ile Asn Asp Glu Pro Val Asp Met Ser Ala Arg Arg Ser 
            100                 105                 110         


Glu Pro Glu Arg Gly Arg Leu Thr Pro Ser Pro Asp Ile Ile Val Leu 
        115                 120                 125             


Ser Asp Asn Glu Ala Ser Ser Pro Arg Ser Ser Ser Arg Met Glu Glu 
    130                 135                 140                 


Arg Leu Lys Ala Ala Asn Leu Glu Met Phe Lys Gly Lys Gly Ile Glu 
145                 150                 155                 160 


Glu Arg Gln Gln Leu Ile Lys Gln Leu Arg Asp Glu Leu Arg Leu Glu 
                165                 170                 175     


Glu Ala Arg Leu Val Leu Leu Lys Lys Leu Arg Gln Ser Gln Leu Gln 
            180                 185                 190         


Lys Glu Asn Val Val Gln Lys Thr Pro Val Val Gln Asn Ala Ala Ser 
        195                 200                 205             


Ile Val Gln Pro Ser Pro Ala His Val Gly Gln Gln Gly Leu Ser Lys 
    210                 215                 220                 


Leu Pro Ser Arg Pro Gly Ala Gln Gly Val Glu Pro Gln Asn Leu Arg 
225                 230                 235                 240 


Thr Leu Gln Gly His Ser Val Ile Arg Ser Ala Thr Asn Thr Thr Leu 
                245                 250                 255     


Pro His Met Leu Met Ser Gln Arg Val Ile Ala Pro Asn Pro Ala Gln 
            260                 265                 270         


Leu Gln Gly Gln Arg Gly Pro Pro Lys Pro Gly Leu Val Arg Thr Thr 
        275                 280                 285             


Thr Pro Asn Met Asn Pro Ala Ile Asn Tyr Gln Pro Gln Ser Ser Ser 
    290                 295                 300                 


Ser Val Pro Cys Gln Arg Thr Thr Ser Ser Ala Ile Tyr Met Asn Leu 
305                 310                 315                 320 


Ala Ser His Ile Gln Pro Gly Thr Val Asn Arg Val Ser Ser Pro Leu 
                325                 330                 335     


Pro Ser Pro Ser Ala Met Thr Asp Ala Ala Asn Ser Gln Ala Ala Ala 
            340                 345                 350         


Lys Leu Ala Leu Arg Lys Gln Leu Glu Lys Thr Leu Leu Glu Ile Pro 
        355                 360                 365             


Pro Pro Lys Pro Pro Ala Pro Leu Leu His Phe Leu Pro Ser Ala Ala 
    370                 375                 380                 


Asn Ser Glu Phe Ile Tyr Met Val Gly Leu Glu Glu Val Val Gln Ser 
385                 390                 395                 400 


Val Ile Asp Ser Gln Gly Lys Ser Cys Ala Ser Leu Leu Arg Val Glu 
                405                 410                 415     


Pro Phe Val Cys Ala Gln Cys Arg Thr Asp Phe Thr Pro His Trp Lys 
            420                 425                 430         


Gln Glu Lys Asn Gly Lys Ile Leu Cys Glu Gln Cys Met Thr Ser Asn 
        435                 440                 445             


Gln Lys Lys Ala Leu Lys Ala Glu His Thr Asn Arg Leu Lys Asn Ala 
    450                 455                 460                 


Phe Val Lys Ala Leu Gln Gln Glu Gln Glu Ile Glu Gln Arg Leu Gln 
465                 470                 475                 480 


Gln Gln Ala Ala Leu Ser Pro Thr Thr Ala Pro Ala Val Ser Ser Val 
                485                 490                 495     


Ser Lys Gln Glu Thr Ile Met Arg His His Thr Leu Arg Gln Ala Pro 
            500                 505                 510         


Gln Pro Gln Ser Ser Leu Gln Arg Gly Ile Pro Thr Ser Ala Arg Ser 
        515                 520                 525             


Met Leu Ser Asn Phe Ala Gln Ala Pro Gln Leu Ser Val Pro Gly Gly 
    530                 535                 540                 


Leu Leu Gly Met Pro Gly Val Asn Ile Ala Tyr Leu Asn Thr Gly Ile 
545                 550                 555                 560 


Gly Gly His Lys Gly Pro Ser Leu Ala Asp Arg Gln Arg Glu Tyr Leu 
                565                 570                 575     


Leu Asp Met Ile Pro Pro Arg Ser Ile Ser Gln Ser Ile Ser Gly Gln 
            580                 585                 590         


Lys 
    

<210>  732
<211>  822
<212>  DNA
<213>  Homo sapiens

<400>  732
agtgataaaa taaaacccca gtaattcatc agccttaatt atatcagttg gttcatcacc     60

tccagccaac ttcttagagc cagctttcct ggagaaagag aggaggatcc cttgatcatt    120

gaagcaagtt agctgcttat acccagaaat ctcagtgtac cacccccacc aaactctttt    180

gccttttcca tattccacca actagccaac aacattagag gtaagaacac ctccaggttt    240

tctggttagg aaattgggtg ggccaggtgc agtgattcat gcctgtaatc ccagcacttt    300

ggggaggcta aggtgagagg attgcttgag cccaggagtg ccagaccagc ctgggcaaca    360

aagtcagatt gtgtctctgt ttaaaaaaaa aaaaaaaaaa ggaaattggg tattgggtgc    420

tgtcctgctc aatcacctga tgtgatgact cccaacagga aattgaacag cgattacagc    480

agcaggcagc cctctccccc actacggctc cagctgtgtc cagtgtcagt aaacaagaga    540

ccatcatgag acatcatacg cttcggcagg ctccacagcc ccagagcagc ctccagcgtg    600

gcatacccac atctgcccgc tccatgcttt caaactttgc acaggcaccc cagttgtctg    660

tgccaggtgg cctccttggt atgccaggta agaaggatta atctgaaaat gtttctcatg    720

ggtcagctgt tagttagtat acagttctgt agcagcccct ttaagggaat tgttccttta    780

ctttctgttc tttctttagg gcatacactc tcactcttct gt                       822


<210>  733
<211>  51
<212>  PRT
<213>  Homo sapiens

<400>  733


Met Arg His His Thr Leu Arg Gln Ala Pro Gln Pro Gln Ser Ser Leu 
1               5                   10                  15      


Gln Arg Gly Ile Pro Thr Ser Ala Arg Ser Met Leu Ser Asn Phe Ala 
            20                  25                  30          


Gln Ala Pro Gln Leu Ser Val Pro Gly Gly Leu Leu Gly Met Pro Gly 
        35                  40                  45              


Lys Lys Asp 
    50      

<210>  734
<211>  445
<212>  DNA
<213>  Homo sapiens

<400>  734
agacatctga ggggcaaagg agacatgtta ctaaaaattt attgacaata taatgatgta     60

ctcttgaatc taagatatgc agtatttggg tccttccttt atccatatag cttcagttac    120

ctgtttctct ttatctacaa agattctaag tctgatgctc acagctaagg ttagggctga    180

gtacgctgtt cattgagact tttatacctc tgactctgga aataagaaag gcttttcaaa    240

aatccatctg ggctgggtgt agtggcatga acaagaaaat tttcaaggtc aatgaagcaa    300

ctcctaatac tgactgaaat attaactaca gagagttcag gagatcatgc tatattctgc    360

taacacatcc ataaatttct taagggaaaa aatgtcatca aactacagat tttatactca    420

ttgcttttta tatccaaggc aacat                                          445


<210>  735
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  735


Met Gln Tyr Leu Gly Pro Ser Phe Ile His Ile Ala Ser Val Thr Cys 
1               5                   10                  15      


Phe Ser Leu Ser Thr Lys Ile Leu Ser Leu Met Leu Thr Ala Lys Val 
            20                  25                  30          


Arg Ala Glu Tyr Ala Val His 
        35                  

<210>  736
<211>  1320
<212>  DNA
<213>  Homo sapiens

<400>  736
aaaccgggat tcccctttgg ccatctctca ttctttcaat tctaaagatg gagactggcg     60

aacggcgatg gggtctgcgg tgggcggtgt ttcgtcgcga cagactctag gaaatttcac    120

gatagaacta gctttaggcg cttgagcctt gccgtctttt tggggtgtgg cctgtctccg    180

tctgccaaag gctttgagct tcctggtgtt catcgtacct ccgcttggtc ctgtcgtgac    240

taaaccacga cagcaggaaa aaaaaaaaag cagctagcca agttgctgag gaattacggt    300

gtgcagagcc ctcgcagctc cttctcttgg gaactcctgg tctggttagg ttctcagcga    360

ggaaacagcc tcccaccccg cccgattcca cctaattaac tcaagggcca gctccttttg    420

ctggcctccc tgcttccacg gagcagttag gcccgcctaa actcagcgag cgtttctgga    480

gcaccttgag gatagggacc aagtaacaga gtccgggtgt taaggttatg atagtagtta    540

acgtttttgg aaagagactg tgtcaggctc tgtgctaaga actttacatg aagtatttat    600

tcctcatgac tgtgagctcc tctaggacac tgaaaaagca tcctaacatg ctcaagacag    660

gataggaaat ggtcctctgg cttgaaagac tcagcatcca gaagtagtac ctcactctcc    720

atccagtggt caccccccag aaatgtgctc tccctgtctc accaggccct acccacctgc    780

ctgggagctg cctgcctctt gatgtgctga cacctgctcc tgctgctgct gctgctgctg    840

ctgctgttgc tgctgctgct gctgttgccg ttctctcaag ggctggcgga actgagcagc    900

ccccaggaca acattccgga gcttggccca gcgcagacgc ccacctggtg tgccagacgg    960

ccacttgctt tccaacacag cctaccaagc acagtgccca tcaggatggc ctacctcgac   1020

accctaaccc tgcctcatac ccactccctg tcttggagcc ccagggaccg cccttcccct   1080

gcagacatcc tgtctaggac tgtccggcca atggctcagc caggaacaag agcccagaag   1140

agacagtagg cagcagctgc ctcccaaggg gcctagaaga acccagaggc agtggagaaa   1200

atttgtaccc agaccttgct gcttagaaat ataaaatata tggctctgaa gaaatcattt   1260

catttatttg gtcattagtc tcctcatcta aaaaacagga ggcagtttag tatcatggct   1320


<210>  737
<211>  47
<212>  PRT
<213>  Homo sapiens

<400>  737


Met Ala Tyr Leu Asp Thr Leu Thr Leu Pro His Thr His Ser Leu Ser 
1               5                   10                  15      


Trp Ser Pro Arg Asp Arg Pro Ser Pro Ala Asp Ile Leu Ser Arg Thr 
            20                  25                  30          


Val Arg Pro Met Ala Gln Pro Gly Thr Arg Ala Gln Lys Arg Gln 
        35                  40                  45          

<210>  738
<211>  320
<212>  DNA
<213>  Homo sapiens

<400>  738
agctcctcta ggacactgaa aaagcatcct aacatgctca agacaggata ggaaatggtc     60

ctctggcttg aaagactcag catccagaag tagtacctca tacccactcc ctgtcttgga    120

gccccaggga ccgcccttcc cctgcagaca tcctgtctag gactgtccgg ccaatggctc    180

agccaggaac aagagcccag aagagacagt aggcagcagc tgcctcccaa ggggcctaga    240

agaacccaga ggcagtggag aaaatttgta cccagacctt gctgcttaga aatataaaat    300

atatggctct gaagaaatca                                                320


<210>  739
<211>  67
<212>  PRT
<213>  Homo sapiens

<400>  739


Tyr Leu Ile Pro Thr Pro Cys Leu Gly Ala Pro Gly Thr Ala Leu Pro 
1               5                   10                  15      


Leu Gln Thr Ser Cys Leu Gly Leu Ser Gly Gln Trp Leu Ser Gln Glu 
            20                  25                  30          


Gln Glu Pro Arg Arg Asp Ser Arg Gln Gln Leu Pro Pro Lys Gly Pro 
        35                  40                  45              


Arg Arg Thr Gln Arg Gln Trp Arg Lys Phe Val Pro Arg Pro Cys Cys 
    50                  55                  60                  


Leu Glu Ile 
65          

<210>  740
<211>  2530
<212>  DNA
<213>  Homo sapiens

<400>  740
ctgagtcttc gccgttcctc agagcgcctc agtgacaccc ctggatcctt ccagtcacct     60

tccctggaag tgaggataac ccctcccaca cagatgtgct tgaacacaca tagcacacac    120

tcaccctgtc caaggcagga gatggggagg aggtgggagg ggctggggaa ggggcatggg    180

ctccagagtg ctggcggcca gacagcacct acttcccgac tctccctgcc cacagattct    240

gctgtccagc tgctccctgt gccgtgcctg tgattcgctg gtgtatgatg aggaaatcat    300

ggctggctgg gcacctgatg actctaacct caacacaacc tgccccttct gcgcctgccc    360

ctttgtgccc ctgctcagtg tccagaccct tgattcccgg cccaggtgcc caaggcaggg    420

caagtgctgt gggtgggaat agggaggtga aggtccaaaa gctgacccct gctgctatcc    480

ccctgcagtg tccccagccc caaatctgct ggtgccagtg gcagcaaaga tgctcctgtc    540

cctggtggtc ctggccctgt gctcagtgac cgaaggctct gccttgctct ggatgagccc    600

cagctctgca acgggcacat gggggtaagg gctgggccaa aggggcatga ggaacgggaa    660

tgttgccctg tgtggggcct gtggggtgcc agggagagat gggcacatct cttgcccttg    720

agggcaaggg gcatcccaaa agctgttgga tgtggtggct cagtgggagg caaggctctg    780

gggatgtaca tgccctctac tgccctcccc ctttgtgcct gatagggagc ctcccggcgg    840

gttgagagtg gggcatgggc atacctgagc cccctggtgc tgcgtaagga gctggagtcg    900

ctggtagaga acgagggcag tgaggtgctg gcgttgcctg aactgccctc tgcccacccc    960

atcatcttct ggaacctttt gtggtatttc caacggctac gcctgcccag tattctacca   1020

ggcctggtgc tggcctcctg tgatgggcct tcgcactccc aggccccatc tccttggcta   1080

acccctgatc cagcctctgt tcaggtacgg ctgctgtggg atgtactgac ccctgacccc   1140

aatagctgcc cacctctcta tgtgctctgg agggtccaca gtgagtctgg tatttggcct   1200

gggtggggag ggtgggtccc atacccagag ggctcagtga ttctggtggc cttctttcct   1260

ttcatccagg ccagatcccc cagcgggtgg tatggccagg ccctgtacct gcatccctta   1320

gtttggcact gttggagtca gtgctgcgcc atgttggact caatgaagtg cacaaggctg   1380

tggggctcct gctggaaact ctagggcccc cacccactgg cctgcacctg cagaggtatg   1440

gtgctaccat ctgggtgatc cctggtctgt ccggggctcc acaccccttt tctctcactc   1500

atacacttct gcctccacta aaggggaatc taccgtgaga tattattcct gacaatggct   1560

gctctgggca aggaccacgt ggacatagtg gccttcgata agaagtacaa gtctgccttt   1620

aacaagctgg ccagcagcat gggcaaggag gagctgaggc accggcgggc gcagatgccc   1680

actcccaagg ccattgactg ccgaaaatgt tttggagcac ctccagaatg ctagagacct   1740

taagcttccc tctccagcct agggtgggga agtgaggaag aagggattct agagttaaac   1800

tgcttccctg ttgccttcat ggagttggga acaggctggg aaggatgccc agtcaaaggc   1860

tccaagcgag gacaacagga agagggatcc actgttacca aaagtcctga ttcccccatc   1920

accaacctac ccagtttgtt cgtgctgatg ttgggggaga tctgggggga gttggtacag   1980

ctctgttctt cccttgtcct ataccgggaa ctcccctcca gggtacccac agatctgcat   2040

tgccctggtc attttagaag tttttgtttt aaaaaacaac tggaaagatg cagagctact   2100

gagcctttgc cctgaatggg aggtagggat gtcattctcc accaataatg gtccctcttc   2160

cctgacgttg ctgaaggagc ccaaggctct ccatgccttt ctacctaagt gtttgtattt   2220

tattttaaat tatttattct ggagccacag cccccttgct tatgaggttc ttatggagag   2280

tgagaaaggg aagggaaata gggcaccatg gtccggtggt ttgtagttcc ttcaaagtca   2340

ggcactggga gctagaggag tctcaagctc cccttaggaa gaactggtgc cccctccagt   2400

cctaattttt cttgcctgcc ccgccttggg gaatgcctca cccacccagg tcctgacctg   2460

tgcaataagg attgttccct gcgaagtttt gttggatgta aatatagtaa aagctgcttc   2520

tgtctttttc                                                          2530


<210>  741
<211>  59
<212>  PRT
<213>  Homo sapiens

<400>  741


Met Ala Ala Leu Gly Lys Asp His Val Asp Ile Val Ala Phe Asp Lys 
1               5                   10                  15      


Lys Tyr Lys Ser Ala Phe Asn Lys Leu Ala Ser Ser Met Gly Lys Glu 
            20                  25                  30          


Glu Leu Arg His Arg Arg Ala Gln Met Pro Thr Pro Lys Ala Ile Asp 
        35                  40                  45              


Cys Arg Lys Cys Phe Gly Ala Pro Pro Glu Cys 
    50                  55                  

<210>  742
<211>  413
<212>  DNA
<213>  Homo sapiens

<400>  742
ctgtgtctgc ctgcctatgt gcggtcggca ccctcccgag tgcaggcact gcacacagcc     60

taccatgtgc tctccatgcc tttctaccta agtgtttgta ttttatttta aattatttat    120

tctggagcca cagccccctt gcttatgagg ttcttatgga gagtgagaaa gggaagggaa    180

atagggcacc atggtccggt ggtttgtagt tccttcaaag tcaggcactg ggagctagag    240

gagtctcaag ctccccttag gaagaactgg tgccccctcc agtcctaatt tttcttgcct    300

gccccgcctt ggggaatgcc tcacccaccc aggtcctgac ctgtgcaata aggattgttc    360

cctgcgaagt tttgttggat gtaaatatag taaaagctgc ttctgtcttt ttc           413


<210>  743
<211>  47
<212>  PRT
<213>  Homo sapiens

<400>  743


Met Arg Phe Leu Trp Arg Val Arg Lys Gly Arg Glu Ile Gly His His 
1               5                   10                  15      


Gly Pro Val Val Cys Ser Ser Phe Lys Val Arg His Trp Glu Leu Glu 
            20                  25                  30          


Glu Ser Gln Ala Pro Leu Arg Lys Asn Trp Cys Pro Leu Gln Ser 
        35                  40                  45          

<210>  744
<211>  5114
<212>  DNA
<213>  Homo sapiens

<400>  744
tgcttggcac ataagcaacc ctgtataaac attagttgct attatcactg tcattatcat     60

catcatcatc acctccgtct tctgagcact ctgggaatcc aggggctggc catgtcttct    120

agggcacctg cccatgctca agggccagcc tctctgcacg gggctccagg cagggctgca    180

gcctgtgaag tacagcatcc cttctcctcc ttagagcaca gacccttcct cagagaaggt    240

gctacttctt cccacaccac tttagggtct gtcctggtgg ctcatgcctt taatcccagc    300

attttgggag gctgaggcag gcagatcact tgcgcccagg agtttgtgac tagcctgggc    360

aatgtggcaa aaccttgtct ttacaaaaag tacaaaacaa tcagtcgggc ttggtggtgc    420

gtcccagcta cttgagactg aggtgggaga atcgcttgag cccaggaggc cgagtctgca    480

gtgagccaag attgcgccac tgcactccag cctgggtgac agagcgagac cgtcataaat    540

aaataaataa atagataagt aagaaagacc tggcattgta ctcaccctga tgtgtcccct    600

gtcctaccta ggagatgaaa gttgcacagc ggatggcaca gaagtcagca gctgtgcctg    660

agctgtgggc ccggtgcctg ctggggcact gctatgggct gtggttcctg tgtctgcctg    720

cctatgtgcg gtcggcaccc tcccgagtgc aggcactgca cacagcctac catgtgctgc    780

gccagatgga gagcggcaag gtggtgctcc ctgatgaggt aggcaatcta tgtgaccatg    840

ctcataccca ggcccagtga gccttgtgca gctggagagg gctgtgagag ggaaacttgg    900

tggagactaa ggaaagaagt tgcagagccc cagagctggg cagattatct ataaacattc    960

gtcgagtgaa taagcatgtt cagggtttag cagtgaagac tgtagggtgg cagggtcagc   1020

agaaagggtg ggtggctctg aggtagcccc aggacctgcc aggggccagt gatgtctgtg   1080

agaattgggg aggcaggaag agggtgcttg ctgagacttt ggttttggtt gagagtgagt   1140

ctcccattgt cctgtgcctc tcctggccca ggtgtgttac cgggtactga tgcagctctg   1200

ctcacactat gggcagcctg tgctgtctgt gcgggtcatg ctggagatgc gtcaggcagg   1260

cattgtgccc aacaccatca cctatggcta ctacaataag gtacctactt tggggtgagg   1320

ggtgggatgg cagctgtgcc agggtgtgtg aggggaggct gctgctgctc ccctcgctcc   1380

ttggagattg ggctggtact gtttgcctag gtcctggaac cactgtcatc cacattgcac   1440

tcctgtggtg ccttagcacc tacagtttct cagacgaggc tgctttgatt cccactcatg   1500

acagccctgc ctacaactaa tagtgtcagc cgctaagcca ggcacgggtc catacgcatc   1560

acacatttta catcatttta tcttcacgac agccctatga ggtgggatga tcattatccc   1620

catcttatag aagaggagat gaggttgtag agagttagta actcgtccaa ggtcccgcag   1680

caaagaagtt aaggagtgag aatatgggca cagggctggg tgcagtggct catgcctgta   1740

atctcagcac tttgggaggc tgaggcaggc agatcacctg agatcaggag ttcgagacca   1800

gcctggccaa catggtgaaa ccctgtctct attaaaaata cagaaattag cttggtgtgg   1860

tggtgggtgc ctgtagtccc agctacttgg gaggctgagg caagagaatc acttgaaccc   1920

gggaggcaga ggttgcagtg agccaagatt gcgccactgc gctccagcct gggcgacaga   1980

gcaagactcc gtctcgaaaa aaaagaaaaa agaatatggg cagaggcata tccatatctc   2040

ccgaattcag gcccttagcc atgatactaa actgcctcct gttttttaga tgaggagact   2100

aatgaccaaa taaatgaaat gatttcttca gagccatata ttttatattt ctaagcagca   2160

aggtctgggt acaaattttc tccactgcct ctgggttctt ctaggcccct tgggaggcag   2220

ctgctgccta ctgtctcttc tgggctcttg ttcctggctg agccattggc cggacagtcc   2280

tagacaggat gtctgcaggg gaagggcggt ccctggggct ccaagacagg gagtgggtat   2340

gaggcagggt tagggtgtcg aggtaggcca tcctgatggg cactgtgctt ggtaggctgt   2400

gttggaaagc aagtggccgt ctggcacacc aggtgggcgt ctgcgctggg ccaagctccg   2460

gaatgttgtc ctgggggctg ctcagttccg ccagcccttg agagaacggc aacagcagca   2520

gcagcagcaa cagcagcagc agcagcagca gcagcaggag caggtgtcag cacatcaaga   2580

ggcaggcagc tcccaggcag agccctattt ggagcgccct tcccctactc gccctcttca   2640

gcgccagact acttgggctg ggcgaagtct gagagaccca gcctcacccc ctggacgcct   2700

ggtgaagagt ggtagcctgg gcagtgcccg aggggcacag cccactgtgg aggccggtgt   2760

ggcccacatg atagaggcct tgggggtcct ggaaccccgg ggatcacctg tgccctggca   2820

cgatggaagt ctctcagacc tgagcctgac aggggaggag ccgctccctg gaggcagccc   2880

agggggctca ggctcagccc tgagtgccca gtccactgag gccctggaag ggctaagtgg   2940

gcggggaccc aaggctggtg ggcgacagga tgaggcaggc accccccgac gagggctggg   3000

tgcccgcctc caacagctgc tcactccttc ccgccactcc cctgcctccc gcattccccc   3060

acctgagctg cctcctgacc tgccaccccc agcccgccgc agccccatgg acagtcttct   3120

gcacccccgg gagcgccctg gatccactgc ctccgagagc tcagcctctc tgggcagtga   3180

gtgggacctc tcagaatctt ctctcagcaa cctgagtctt cgccgttcct cagagcgcct   3240

cagtgacacc cctggatcct tccagtcacc ttccctggaa attctgctgt ccagctgctc   3300

cctgtgccgt gcctgtgatt cgctggtgta tgatgaggaa atcatggctg gctgggcacc   3360

tgatgactct aacctcaaca caacctgccc cttctgcgcc tgcccctttg tgcccctgct   3420

cagtgtccag acccttgatt cccggcccag tgtccccagc cccaaatctg ctggtgccag   3480

tggcagcaaa gatgctcctg tccctggtgg tcctggccct gtgctcagtg accgaaggct   3540

ctgccttgct ctggatgagc cccagctctg caacgggcac atggggggag cctcccggcg   3600

ggttgagagt ggggcatggg catacctgag ccccctggtg ctgcgtaagg agctggagtc   3660

gctggtagag aacgagggca gtgaggtgct ggcgttgcct gaactgccct ctgcccaccc   3720

catcatcttc tggaaccttt tgtggtattt ccaacggcta cgcctgccca gtattctacc   3780

aggcctggtg ctggcctcct gtgatgggcc ttcgcactcc caggccccat ctccttggct   3840

aacccctgat ccagcctctg ttcaggtacg gctgctgtgg gatgtactga cccctgaccc   3900

caatagctgc ccacctctct atgtgctctg gagggtccac agccagatcc cccagcgggt   3960

ggtatggcca ggccctgtac ctgcatccct tagtttggca ctgttggagt cagtgctgcg   4020

ccatgttgga ctcaatgaag tgcacaaggc tgtggggctc ctgctggaaa ctctagggcc   4080

cccacccact ggcctgcacc tgcagagggg aatctaccgt gagatattat tcctgacaat   4140

ggctgctctg ggcaaggacc acgtggacat agtggccttc gataagaagt acaagtctgc   4200

ctttaacaag ctggccagca gcatgggcaa ggaggagctg aggcaccggc gggcgcagat   4260

gcccactccc aaggccattg actgccgaaa atgttttgga gcacctccag aatgctagag   4320

accttaagct tccctctcca gcctagggtg gggaagtgag gaagaaggga ttctagagtt   4380

aaactgcttc cctgttgcct tcatggagtt gggaacaggc tgggaaggat gcccagtcaa   4440

aggctccaag cgaggacaac aggaagaggg atccactgtt accaaaagtc ctgattcccc   4500

catcaccaac ctacccagtt tgttcgtgct gatgttgggg gagatctggg gggagttggt   4560

acagctctgt tcttcccttg tcctataccg ggaactcccc tccagggtac ccacagatct   4620

gcattgccct ggtcatttta gaagtttttg ttttaaaaaa caactggaaa gatgcagagc   4680

tactgagcct ttgccctgaa tgggaggtag ggatgtcatt ctccaccaat aatggtccct   4740

cttccctgac gttgctgaag gagcccaagg ctctccatgc ctttctacct aagtgtttgt   4800

attttatttt aaattattta ttctggagcc acagccccct tgcttatgag gttcttatgg   4860

agagtgagaa agggaaggga aatagggcac catggtccgg tggtttgtag ttccttcaaa   4920

gtcaggcact gggagctaga ggagtctcaa gctcccctta ggaagaactg gtgccccctc   4980

cagtcctaat ttttcttgcc tgccccgcct tggggaatgc ctcacccacc caggtcctga   5040

cctgtgcaat aaggattgtt ccctgcgaag ttttgttgga tgtaaatata gtaaaagctg   5100

cttctgtctt tttc                                                     5114


<210>  745
<211>  516
<212>  PRT
<213>  Homo sapiens

<400>  745


Met Ile Glu Ala Leu Gly Val Leu Glu Pro Arg Gly Ser Pro Val Pro 
1               5                   10                  15      


Trp His Asp Gly Ser Leu Ser Asp Leu Ser Leu Thr Gly Glu Glu Pro 
            20                  25                  30          


Leu Pro Gly Gly Ser Pro Gly Gly Ser Gly Ser Ala Leu Ser Ala Gln 
        35                  40                  45              


Ser Thr Glu Ala Leu Glu Gly Leu Ser Gly Arg Gly Pro Lys Ala Gly 
    50                  55                  60                  


Gly Arg Gln Asp Glu Ala Gly Thr Pro Arg Arg Gly Leu Gly Ala Arg 
65                  70                  75                  80  


Leu Gln Gln Leu Leu Thr Pro Ser Arg His Ser Pro Ala Ser Arg Ile 
                85                  90                  95      


Pro Pro Pro Glu Leu Pro Pro Asp Leu Pro Pro Pro Ala Arg Arg Ser 
            100                 105                 110         


Pro Met Asp Ser Leu Leu His Pro Arg Glu Arg Pro Gly Ser Thr Ala 
        115                 120                 125             


Ser Glu Ser Ser Ala Ser Leu Gly Ser Glu Trp Asp Leu Ser Glu Ser 
    130                 135                 140                 


Ser Leu Ser Asn Leu Ser Leu Arg Arg Ser Ser Glu Arg Leu Ser Asp 
145                 150                 155                 160 


Thr Pro Gly Ser Phe Gln Ser Pro Ser Leu Glu Ile Leu Leu Ser Ser 
                165                 170                 175     


Cys Ser Leu Cys Arg Ala Cys Asp Ser Leu Val Tyr Asp Glu Glu Ile 
            180                 185                 190         


Met Ala Gly Trp Ala Pro Asp Asp Ser Asn Leu Asn Thr Thr Cys Pro 
        195                 200                 205             


Phe Cys Ala Cys Pro Phe Val Pro Leu Leu Ser Val Gln Thr Leu Asp 
    210                 215                 220                 


Ser Arg Pro Ser Val Pro Ser Pro Lys Ser Ala Gly Ala Ser Gly Ser 
225                 230                 235                 240 


Lys Asp Ala Pro Val Pro Gly Gly Pro Gly Pro Val Leu Ser Asp Arg 
                245                 250                 255     


Arg Leu Cys Leu Ala Leu Asp Glu Pro Gln Leu Cys Asn Gly His Met 
            260                 265                 270         


Gly Gly Ala Ser Arg Arg Val Glu Ser Gly Ala Trp Ala Tyr Leu Ser 
        275                 280                 285             


Pro Leu Val Leu Arg Lys Glu Leu Glu Ser Leu Val Glu Asn Glu Gly 
    290                 295                 300                 


Ser Glu Val Leu Ala Leu Pro Glu Leu Pro Ser Ala His Pro Ile Ile 
305                 310                 315                 320 


Phe Trp Asn Leu Leu Trp Tyr Phe Gln Arg Leu Arg Leu Pro Ser Ile 
                325                 330                 335     


Leu Pro Gly Leu Val Leu Ala Ser Cys Asp Gly Pro Ser His Ser Gln 
            340                 345                 350         


Ala Pro Ser Pro Trp Leu Thr Pro Asp Pro Ala Ser Val Gln Val Arg 
        355                 360                 365             


Leu Leu Trp Asp Val Leu Thr Pro Asp Pro Asn Ser Cys Pro Pro Leu 
    370                 375                 380                 


Tyr Val Leu Trp Arg Val His Ser Gln Ile Pro Gln Arg Val Val Trp 
385                 390                 395                 400 


Pro Gly Pro Val Pro Ala Ser Leu Ser Leu Ala Leu Leu Glu Ser Val 
                405                 410                 415     


Leu Arg His Val Gly Leu Asn Glu Val His Lys Ala Val Gly Leu Leu 
            420                 425                 430         


Leu Glu Thr Leu Gly Pro Pro Pro Thr Gly Leu His Leu Gln Arg Gly 
        435                 440                 445             


Ile Tyr Arg Glu Ile Leu Phe Leu Thr Met Ala Ala Leu Gly Lys Asp 
    450                 455                 460                 


His Val Asp Ile Val Ala Phe Asp Lys Lys Tyr Lys Ser Ala Phe Asn 
465                 470                 475                 480 


Lys Leu Ala Ser Ser Met Gly Lys Glu Glu Leu Arg His Arg Arg Ala 
                485                 490                 495     


Gln Met Pro Thr Pro Lys Ala Ile Asp Cys Arg Lys Cys Phe Gly Ala 
            500                 505                 510         


Pro Pro Glu Cys 
        515     

<210>  746
<211>  4301
<212>  DNA
<213>  Homo sapiens

<400>  746
ttctggtgcc cctatccctg cctggactct tcccttttcc ttccttgtgg aggatcctca     60

gcccctttcc ctgggcacag cctgcaggaa cacatagctt ccatcaggag ctcttctcta    120

gagcctactt ccaacagcct ctctcaacag gcaccaactc cccaaggcca atgccctctc    180

tttctctctc ctgtgcctcc cactgctgcc tcaaccccct gttcactggt tctcactgcc    240

tggtgcttca gatgatcttc ccactgcact ggcagtgccc ctacattcct ctgtgcccgc    300

tggtgctggc agatgtgctg agtgccccag tgcccttcat tgtgggtatc cactccagct    360

actttgatct gcatgacccg cctgctgatg tcatctgtgt agaccttgat accaacacgc    420

tcttccagac tgaggaaaag aagctcctct cccctcggac cctgccccgc agaccctaca    480

aggttctgct ggccacactg acaaacctgt accagcagct ggaccagaca tacactggac    540

ctgaggagga agcatccctg gagttcctac tgacagacta cgaggcagtg tgtggccgca    600

gggcccggct ggagcgcgaa gtccaaggag ccttcctccg cttcatggcc tgtctgctca    660

agggctaccg ggtcttcctg cgcccactca cccaggcccc ctccgaggga gctcgtgatg    720

ttgacaacct tttcttcctg cagggcttcc tcaaatcccg ggaacgctcc agccacaaac    780

tttactctca gctgctgcac acacagatgt tctcacagtt cattgaggag tgctcttttg    840

gctctgctcg ccatgctgcc cttgaattct ttgactcttg tgttgaaaag gtccacccag    900

agcaggagaa gcctgagccg acacccttag tggagctaga ggagctgtca ggaagtgagc    960

tcactgtctt tatcacacct cccgaggagc ctgccttacc agagggcagt gaatccactc   1020

cccagtactg ctatgatgga ttcccagagc tacgggctga gttgtttgag tctcttcaag   1080

agcaacctgg ggccctgcct gtgccaggcc cttcccgtag cgcccccagc agtcctgctc   1140

ctcgccgtac caaacaggag atgaaagttg cacagcggat ggcacagaag tcagcagctg   1200

tgcctgagct gtgggcccgg tgcctgctgg ggcactgcta tgggctgtgg ttcctgtgtc   1260

tgcctgccta tgtgcggtcg gcaccctccc gagtgcaggc actgcacaca gcctaccatg   1320

tgctgcgcca gatggagagc ggcaaggtgg tgctccctga tgaggtgtgt taccgggtac   1380

tgatgcagct ctgctcacac tatgggcagc ctgtgctgtc tgtgcgggtc atgctggaga   1440

tgcgtcaggc aggcattgtg cccaacacca tcacctatgg ctactacaat aaggctgtgt   1500

tggaaagcaa gtggccgtct ggcacaccag gtgggcgtct gcgctgggcc aagctccgga   1560

atgttgtcct gggggctgct cagttccgcc agcccttgag agaacggcaa cagcagcagc   1620

agcagcaaca gcagcagcag cagcagcagc agcaggagca ggtgtcagca catcaagagg   1680

caggcagctc ccaggcagag ccctatttgg agcgcccttc ccctactcgc cctcttcagc   1740

gccagactac ttgggctggg cgaagtctga gagacccagc ctcaccccct ggacgcctgg   1800

tgaagagtgg tagcctgggc agtgcccgag gggcacagcc cactgtggag gccggtgtgg   1860

cccacatgat agaggccttg ggggtcctgg aaccccgggg atcacctgtg ccctggcacg   1920

atggaagtct ctcagacctg agcctgacag gggaggagcc gctccctgga ggcagcccag   1980

ggggctcagg ctcagccctg agtgcccagt ccactgaggc cctggaaggg ctaagtgggc   2040

ggggacccaa ggctggtggg cgacaggatg aggcaggcac cccccgacga gggctgggtg   2100

cccgcctcca acagctgctc actccttccc gccactcccc tgcctcccgc attcccccac   2160

ctgagctgcc tcctgacctg ccacccccag cccgccgcag ccccatggac agtcttctgc   2220

acccccggga gcgccctgga tccactgcct ccgagagctc agcctctctg ggcagtgagt   2280

gggacctctc agaatcttct ctcagcaacc tgagtcttcg ccgttcctca gagcgcctca   2340

gtgacacccc tggatccttc cagtcacctt ccctggaaat tctgctgtcc agctgctccc   2400

tgtgccgtgc ctgtgattcg ctggtgtatg atgaggaaat catggctggc tgggcacctg   2460

atgactctaa cctcaacaca acctgcccct tctgcgcctg cccctttgtg cccctgctca   2520

gtgtccagac ccttgattcc cggcccagtg tccccagccc caaatctgct ggtgccagtg   2580

gcagcaaaga tgctcctgtc cctggtggtc ctggccctgt gctcagtgac cgaaggctct   2640

gccttgctct ggatgagccc cagctctgca acgggcacat ggggggagcc tcccggcggg   2700

ttgagagtgg ggcatgggca tacctgagcc ccctggtgct gcgtaaggag ctggagtcgc   2760

tggtagagaa cgagggcagt gaggtgctgg cgttgcctga actgccctct gcccacccca   2820

tcatcttctg gaaccttttg tggtatttcc aacggctacg cctgcccagt attctaccag   2880

gcctggtgct ggcctcctgt gatgggcctt cgcactccca ggccccatct ccttggctaa   2940

cccctgatcc agcctctgtt caggtacggc tgctgtggga tgtactgacc cctgacccca   3000

atagctgccc acctctctat gtgctctgga gggtccacag tgagtctggt atttggcctg   3060

ggtggggagg gtgggtccca tacccagagg gctcagtgat tctggtggcc ttctttcctt   3120

tcatccaggc cagatccccc agcgggtggt atggccaggc cctgtacctg catcccttag   3180

tttggcactg ttggagtcag tgctgcgcca tgttggactc aatgaagtgc acaaggctgt   3240

ggggctcctg ctggaaactc tagggccccc acccactggc ctgcacctgc agaggggaat   3300

ctaccgtgag atattattcc tgacaatggc tgctctgggc aaggaccacg tggacatagt   3360

ggccttcgat aagaagtaca agtctgcctt taacaagctg gccagcagca tgggcaagga   3420

ggagctgagg caccggcggg cgcagatgcc cactcccaag gccattgact gccgaaaatg   3480

ttttggagca cctccagaat gctagagacc ttaagcttcc ctctccagcc tagggtgggg   3540

aagtgaggaa gaagggattc tagagttaaa ctgcttccct gttgccttca tggagttggg   3600

aacaggctgg gaaggatgcc cagtcaaagg ctccaagcga ggacaacagg aagagggatc   3660

cactgttacc aaaagtcctg attcccccat caccaaccta cccagtttgt tcgtgctgat   3720

gttgggggag atctgggggg agttggtaca gctctgttct tcccttgtcc tataccggga   3780

actcccctcc agggtaccca cagatctgca ttgccctggt cattttagaa gtttttgttt   3840

taaaaaacaa ctggaaagat gcagagctac tgagcctttg ccctgaatgg gaggtaggga   3900

tgtcattctc caccaataat ggtccctctt ccctgacgtt gctgaaggag cccaaggctc   3960

tccatgcctt tctacctaag tgtttgtatt ttattttaaa ttatttattc tggagccaca   4020

gcccccttgc ttatgaggtt cttatggaga gtgagaaagg gaagggaaat agggcaccat   4080

ggtccggtgg tttgtagttc cttcaaagtc aggcactggg agctagagga gtctcaagct   4140

ccccttagga agaactggtg ccccctccag tcctaatttt tcttgcctgc cccgccttgg   4200

ggaatgcctc acccacccag gtcctgacct gtgcaataag gattgttccc tgcgaagttt   4260

tgttggatgt aaatatagta aaagctgctt ctgtcttttt c                       4301


<210>  747
<211>  1030
<212>  PRT
<213>  Homo sapiens

<400>  747


Met Pro Ser Leu Ser Leu Ser Cys Ala Ser His Cys Cys Leu Asn Pro 
1               5                   10                  15      


Leu Phe Thr Gly Ser His Cys Leu Val Leu Gln Met Ile Phe Pro Leu 
            20                  25                  30          


His Trp Gln Cys Pro Tyr Ile Pro Leu Cys Pro Leu Val Leu Ala Asp 
        35                  40                  45              


Val Leu Ser Ala Pro Val Pro Phe Ile Val Gly Ile His Ser Ser Tyr 
    50                  55                  60                  


Phe Asp Leu His Asp Pro Pro Ala Asp Val Ile Cys Val Asp Leu Asp 
65                  70                  75                  80  


Thr Asn Thr Leu Phe Gln Thr Glu Glu Lys Lys Leu Leu Ser Pro Arg 
                85                  90                  95      


Thr Leu Pro Arg Arg Pro Tyr Lys Val Leu Leu Ala Thr Leu Thr Asn 
            100                 105                 110         


Leu Tyr Gln Gln Leu Asp Gln Thr Tyr Thr Gly Pro Glu Glu Glu Ala 
        115                 120                 125             


Ser Leu Glu Phe Leu Leu Thr Asp Tyr Glu Ala Val Cys Gly Arg Arg 
    130                 135                 140                 


Ala Arg Leu Glu Arg Glu Val Gln Gly Ala Phe Leu Arg Phe Met Ala 
145                 150                 155                 160 


Cys Leu Leu Lys Gly Tyr Arg Val Phe Leu Arg Pro Leu Thr Gln Ala 
                165                 170                 175     


Pro Ser Glu Gly Ala Arg Asp Val Asp Asn Leu Phe Phe Leu Gln Gly 
            180                 185                 190         


Phe Leu Lys Ser Arg Glu Arg Ser Ser His Lys Leu Tyr Ser Gln Leu 
        195                 200                 205             


Leu His Thr Gln Met Phe Ser Gln Phe Ile Glu Glu Cys Ser Phe Gly 
    210                 215                 220                 


Ser Ala Arg His Ala Ala Leu Glu Phe Phe Asp Ser Cys Val Glu Lys 
225                 230                 235                 240 


Val His Pro Glu Gln Glu Lys Pro Glu Pro Thr Pro Leu Val Glu Leu 
                245                 250                 255     


Glu Glu Leu Ser Gly Ser Glu Leu Thr Val Phe Ile Thr Pro Pro Glu 
            260                 265                 270         


Glu Pro Ala Leu Pro Glu Gly Ser Glu Ser Thr Pro Gln Tyr Cys Tyr 
        275                 280                 285             


Asp Gly Phe Pro Glu Leu Arg Ala Glu Leu Phe Glu Ser Leu Gln Glu 
    290                 295                 300                 


Gln Pro Gly Ala Leu Pro Val Pro Gly Pro Ser Arg Ser Ala Pro Ser 
305                 310                 315                 320 


Ser Pro Ala Pro Arg Arg Thr Lys Gln Glu Met Lys Val Ala Gln Arg 
                325                 330                 335     


Met Ala Gln Lys Ser Ala Ala Val Pro Glu Leu Trp Ala Arg Cys Leu 
            340                 345                 350         


Leu Gly His Cys Tyr Gly Leu Trp Phe Leu Cys Leu Pro Ala Tyr Val 
        355                 360                 365             


Arg Ser Ala Pro Ser Arg Val Gln Ala Leu His Thr Ala Tyr His Val 
    370                 375                 380                 


Leu Arg Gln Met Glu Ser Gly Lys Val Val Leu Pro Asp Glu Val Cys 
385                 390                 395                 400 


Tyr Arg Val Leu Met Gln Leu Cys Ser His Tyr Gly Gln Pro Val Leu 
                405                 410                 415     


Ser Val Arg Val Met Leu Glu Met Arg Gln Ala Gly Ile Val Pro Asn 
            420                 425                 430         


Thr Ile Thr Tyr Gly Tyr Tyr Asn Lys Ala Val Leu Glu Ser Lys Trp 
        435                 440                 445             


Pro Ser Gly Thr Pro Gly Gly Arg Leu Arg Trp Ala Lys Leu Arg Asn 
    450                 455                 460                 


Val Val Leu Gly Ala Ala Gln Phe Arg Gln Pro Leu Arg Glu Arg Gln 
465                 470                 475                 480 


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Glu 
                485                 490                 495     


Gln Val Ser Ala His Gln Glu Ala Gly Ser Ser Gln Ala Glu Pro Tyr 
            500                 505                 510         


Leu Glu Arg Pro Ser Pro Thr Arg Pro Leu Gln Arg Gln Thr Thr Trp 
        515                 520                 525             


Ala Gly Arg Ser Leu Arg Asp Pro Ala Ser Pro Pro Gly Arg Leu Val 
    530                 535                 540                 


Lys Ser Gly Ser Leu Gly Ser Ala Arg Gly Ala Gln Pro Thr Val Glu 
545                 550                 555                 560 


Ala Gly Val Ala His Met Ile Glu Ala Leu Gly Val Leu Glu Pro Arg 
                565                 570                 575     


Gly Ser Pro Val Pro Trp His Asp Gly Ser Leu Ser Asp Leu Ser Leu 
            580                 585                 590         


Thr Gly Glu Glu Pro Leu Pro Gly Gly Ser Pro Gly Gly Ser Gly Ser 
        595                 600                 605             


Ala Leu Ser Ala Gln Ser Thr Glu Ala Leu Glu Gly Leu Ser Gly Arg 
    610                 615                 620                 


Gly Pro Lys Ala Gly Gly Arg Gln Asp Glu Ala Gly Thr Pro Arg Arg 
625                 630                 635                 640 


Gly Leu Gly Ala Arg Leu Gln Gln Leu Leu Thr Pro Ser Arg His Ser 
                645                 650                 655     


Pro Ala Ser Arg Ile Pro Pro Pro Glu Leu Pro Pro Asp Leu Pro Pro 
            660                 665                 670         


Pro Ala Arg Arg Ser Pro Met Asp Ser Leu Leu His Pro Arg Glu Arg 
        675                 680                 685             


Pro Gly Ser Thr Ala Ser Glu Ser Ser Ala Ser Leu Gly Ser Glu Trp 
    690                 695                 700                 


Asp Leu Ser Glu Ser Ser Leu Ser Asn Leu Ser Leu Arg Arg Ser Ser 
705                 710                 715                 720 


Glu Arg Leu Ser Asp Thr Pro Gly Ser Phe Gln Ser Pro Ser Leu Glu 
                725                 730                 735     


Ile Leu Leu Ser Ser Cys Ser Leu Cys Arg Ala Cys Asp Ser Leu Val 
            740                 745                 750         


Tyr Asp Glu Glu Ile Met Ala Gly Trp Ala Pro Asp Asp Ser Asn Leu 
        755                 760                 765             


Asn Thr Thr Cys Pro Phe Cys Ala Cys Pro Phe Val Pro Leu Leu Ser 
    770                 775                 780                 


Val Gln Thr Leu Asp Ser Arg Pro Ser Val Pro Ser Pro Lys Ser Ala 
785                 790                 795                 800 


Gly Ala Ser Gly Ser Lys Asp Ala Pro Val Pro Gly Gly Pro Gly Pro 
                805                 810                 815     


Val Leu Ser Asp Arg Arg Leu Cys Leu Ala Leu Asp Glu Pro Gln Leu 
            820                 825                 830         


Cys Asn Gly His Met Gly Gly Ala Ser Arg Arg Val Glu Ser Gly Ala 
        835                 840                 845             


Trp Ala Tyr Leu Ser Pro Leu Val Leu Arg Lys Glu Leu Glu Ser Leu 
    850                 855                 860                 


Val Glu Asn Glu Gly Ser Glu Val Leu Ala Leu Pro Glu Leu Pro Ser 
865                 870                 875                 880 


Ala His Pro Ile Ile Phe Trp Asn Leu Leu Trp Tyr Phe Gln Arg Leu 
                885                 890                 895     


Arg Leu Pro Ser Ile Leu Pro Gly Leu Val Leu Ala Ser Cys Asp Gly 
            900                 905                 910         


Pro Ser His Ser Gln Ala Pro Ser Pro Trp Leu Thr Pro Asp Pro Ala 
        915                 920                 925             


Ser Val Gln Val Arg Leu Leu Trp Asp Val Leu Thr Pro Asp Pro Asn 
    930                 935                 940                 


Ser Cys Pro Pro Leu Tyr Val Leu Trp Arg Val His Ser Glu Ser Gly 
945                 950                 955                 960 


Ile Trp Pro Gly Trp Gly Gly Trp Val Pro Tyr Pro Glu Gly Ser Val 
                965                 970                 975     


Ile Leu Val Ala Phe Phe Pro Phe Ile Gln Ala Arg Ser Pro Ser Gly 
            980                 985                 990         


Trp Tyr Gly Gln Ala Leu Tyr Leu  His Pro Leu Val Trp  His Cys Trp 
        995                 1000                 1005             


Ser Gln  Cys Cys Ala Met Leu  Asp Ser Met Lys Cys  Thr Arg Leu 
    1010                 1015                 1020             


Trp Gly  Ser Cys Trp Lys Leu  
    1025                 1030 

<210>  748
<211>  4572
<212>  DNA
<213>  Homo sapiens

<400>  748
ttgtggggag gggagcttta atgaccaagg acatggtagg tgctgggcag gtgggtgcag     60

ctgttgaggt ttatgcaggc tgggtccagg tggtggctgt gcctggcatc tggggaaggg    120

tccccagggt atcctggtga ccctttcccc acctcggcat tgcctgcagt ggtgccagct    180

tcctgcagct gctgcagagc ctgggccctg agctggctat cacactgctg ctggctgtgc    240

tcacagagca caagctgcta gtccactcgc tgcggccaga cctgctcacc agcgtctgtg    300

aggccctcgt ctcggtgagt gccgccccgc ctggcccatc ttccccagaa ccatggttct    360

ttctggtgcc cctatccctg cctggactct tcccttttcc ttccttgtgg aggatcctca    420

gcccctttcc ctgggcacag cctgcaggaa cacatagctt ccatcaggag ctcttctcta    480

gagcctactt ccaacagcct ctctcaacag gcaccaactc cccaaggcca atgccctctc    540

tttctctctc ctgtgcctcc cactgctgcc tcaaccccct gttcactggt tctcactgcc    600

tggtgcttca gatgatcttc ccactgcact ggcagtgccc ctacattcct ctgtgcccgc    660

tggtgctggc agatgtgctg agtgccccag tgcccttcat tgtgggtatc cactccagct    720

actttgatct gcatgacccg cctgctgatg tcatctgtgt agaccttgat accaacacgc    780

tcttccagac tgaggaaaag aagctcctct cccctcggac cctgccccgc agaccctaca    840

aggttctgct ggccacactg acaaacctgt accagcagct ggaccagaca tacactggac    900

ctgaggagga agcatccctg gagttcctac tgacagacta cgaggcagtg tgtggccgca    960

gggcccggct ggagcgcgaa gtccaaggag ccttcctccg cttcatggcc tgtctgctca   1020

agggctaccg ggtcttcctg cgcccactca cccaggcccc ctccgaggga gctcgtgatg   1080

ttgacaacct tttcttcctg cagggcttcc tcaaatcccg ggaacgctcc agccacaaac   1140

tttactctca gctgctgcac acacagatgt tctcacagtt cattgaggag tgctcttttg   1200

gctctgctcg ccatgctgcc cttgaattct ttgactcttg tgttgaaaag gtccacccag   1260

agcaggagaa gcctgagccg acacccttag tggagctaga ggagctgtca ggaagtgagc   1320

tcactgtctt tatcacacct cccgaggagc ctgccttacc agagggcagt gaatccactc   1380

cccagtactg ctatgatgga ttcccagagc tacgggctga gttgtttgag tctcttcaag   1440

agcaacctgg ggccctgcct gtgccaggcc cttcccgtag cgcccccagc agtcctgctc   1500

ctcgccgtac caaacaggag atgaaagttg cacagcggat ggcacagaag tcagcagctg   1560

tgcctgagct gtgggcccgg tgcctgctgg ggcactgcta tgggctgtgg ttcctgtgtc   1620

tgcctgccta tgtgcggtcg gcaccctccc gagtgcaggc actgcacaca gcctaccatg   1680

tgctgcgcca gatggagagc ggcaaggtgg tgctccctga tgaggtgtgt taccgggtac   1740

tgatgcagct ctgctcacac tatgggcagc ctgtgctgtc tgtgcgggtc atgctggaga   1800

tgcgtcaggc aggcattgtg cccaacacca tcacctatgg ctactacaat aaggctgtgt   1860

tggaaagcaa gtggccgtct ggcacaccag gtgggcgtct gcgctgggcc aagctccgga   1920

atgttgtcct gggggctgct cagttccgcc agcccttgag agaacggcaa cagcagcagc   1980

agcagcaaca gcagcagcag cagcagcagc agcaggagca ggtgtcagca catcaagagg   2040

caggcagctc ccaggcagag ccctatttgg agcgcccttc ccctactcgc cctcttcagc   2100

gccagactac ttgggctggg cgaagtctga gagacccagc ctcaccccct ggacgcctgg   2160

tgaagagtgg tagcctgggc agtgcccgag gggcacagcc cactgtggag gccggtgtgg   2220

cccacatgat agaggccttg ggggtcctgg aaccccgggg atcacctgtg ccctggcacg   2280

atggaagtct ctcagacctg agcctgacag gggaggagcc gctccctgga ggcagcccag   2340

ggggctcagg ctcagccctg agtgcccagt ccactgaggc cctggaaggg ctaagtgggc   2400

ggggacccaa ggctggtggg cgacaggatg aggcaggcac cccccgacga gggctgggtg   2460

cccgcctcca acagctgctc actccttccc gccactcccc tgcctcccgc attcccccac   2520

ctgagctgcc tcctgacctg ccacccccag cccgccgcag ccccatggac agtcttctgc   2580

acccccggga gcgccctgga tccactgcct ccgagagctc agcctctctg ggcagtgagt   2640

gggacctctc agaatcttct ctcagcaacc tgagtcttcg ccgttcctca gagcgcctca   2700

gtgacacccc tggatccttc cagtcacctt ccctggaaat tctgctgtcc agctgctccc   2760

tgtgccgtgc ctgtgattcg ctggtgtatg atgaggaaat catggctggc tgggcacctg   2820

atgactctaa cctcaacaca acctgcccct tctgcgcctg cccctttgtg cccctgctca   2880

gtgtccagac ccttgattcc cggcccagtg tccccagccc caaatctgct ggtgccagtg   2940

gcagcaaaga tgctcctgtc cctggtggtc ctggccctgt gctcagtgac cgaaggctct   3000

gccttgctct ggatgagccc cagctctgca acgggcacat ggggggagcc tcccggcggg   3060

ttgagagtgg ggcatgggca tacctgagcc ccctggtgct gcgtaaggag ctggagtcgc   3120

tggtagagaa cgagggcagt gaggtgctgg cgttgcctga actgccctct gcccacccca   3180

tcatcttctg gaaccttttg tggtatttcc aacggctacg cctgcccagt attctaccag   3240

gcctggtgct ggcctcctgt gatgggcctt cgcactccca ggccccatct ccttggctaa   3300

cccctgatcc agcctctgtt caggtacggc tgctgtggga tgtactgacc cctgacccca   3360

atagctgccc acctctctat gtgctctgga gggtccacag ccagatcccc cagcgggtgg   3420

tatggccagg ccctgtacct gcatccctta gtttggcact gttggagtca gtgctgcgcc   3480

atgttggact caatgaagtg cacaaggctg tggggctcct gctggaaact ctagggcccc   3540

cacccactgg cctgcacctg cagaggggaa tctaccgtga gatattattc ctgacaatgg   3600

ctgctctggg caaggaccac gtggacatag tggccttcga taagaagtac aagtctgcct   3660

ttaacaagct ggccagcagc atgggcaagg aggagctgag gcaccggcgg gcgcagatgc   3720

ccactcccaa ggccattgac tgccgaaaat gttttggagc acctccagaa tgctagagac   3780

cttaagcttc cctctccagc ctagggtggg gaagtgagga agaagggatt ctagagttaa   3840

actgcttccc tgttgccttc atggagttgg gaacaggctg ggaaggatgc ccagtcaaag   3900

gctccaagcg aggacaacag gaagagggat ccactgttac caaaagtcct gattccccca   3960

tcaccaacct acccagtttg ttcgtgctga tgttggggga gatctggggg gagttggtac   4020

agctctgttc ttcccttgtc ctataccggg aactcccctc cagggtaccc acagatctgc   4080

attgccctgg tcattttaga agtttttgtt ttaaaaaaca actggaaaga tgcagagcta   4140

ctgagccttt gccctgaatg ggaggtaggg atgtcattct ccaccaataa tggtccctct   4200

tccctgacgt tgctgaagga gcccaaggct ctccatgcct ttctacctaa gtgtttgtat   4260

tttattttaa attatttatt ctggagccac agcccccttg cttatgaggt tcttatggag   4320

agtgagaaag ggaagggaaa tagggcacca tggtccggtg gtttgtagtt ccttcaaagt   4380

caggcactgg gagctagagg agtctcaagc tccccttagg aagaactggt gccccctcca   4440

gtcctaattt ttcttgcctg ccccgccttg gggaatgcct cacccaccca ggtcctgacc   4500

tgtgcaataa ggattgttcc ctgcgaagtt ttgttggatg taaatatagt aaaagctgct   4560

tctgtctttt tc                                                       4572


<210>  749
<211>  1081
<212>  PRT
<213>  Homo sapiens

<400>  749


Met Pro Ser Leu Ser Leu Ser Cys Ala Ser His Cys Cys Leu Asn Pro 
1               5                   10                  15      


Leu Phe Thr Gly Ser His Cys Leu Val Leu Gln Met Ile Phe Pro Leu 
            20                  25                  30          


His Trp Gln Cys Pro Tyr Ile Pro Leu Cys Pro Leu Val Leu Ala Asp 
        35                  40                  45              


Val Leu Ser Ala Pro Val Pro Phe Ile Val Gly Ile His Ser Ser Tyr 
    50                  55                  60                  


Phe Asp Leu His Asp Pro Pro Ala Asp Val Ile Cys Val Asp Leu Asp 
65                  70                  75                  80  


Thr Asn Thr Leu Phe Gln Thr Glu Glu Lys Lys Leu Leu Ser Pro Arg 
                85                  90                  95      


Thr Leu Pro Arg Arg Pro Tyr Lys Val Leu Leu Ala Thr Leu Thr Asn 
            100                 105                 110         


Leu Tyr Gln Gln Leu Asp Gln Thr Tyr Thr Gly Pro Glu Glu Glu Ala 
        115                 120                 125             


Ser Leu Glu Phe Leu Leu Thr Asp Tyr Glu Ala Val Cys Gly Arg Arg 
    130                 135                 140                 


Ala Arg Leu Glu Arg Glu Val Gln Gly Ala Phe Leu Arg Phe Met Ala 
145                 150                 155                 160 


Cys Leu Leu Lys Gly Tyr Arg Val Phe Leu Arg Pro Leu Thr Gln Ala 
                165                 170                 175     


Pro Ser Glu Gly Ala Arg Asp Val Asp Asn Leu Phe Phe Leu Gln Gly 
            180                 185                 190         


Phe Leu Lys Ser Arg Glu Arg Ser Ser His Lys Leu Tyr Ser Gln Leu 
        195                 200                 205             


Leu His Thr Gln Met Phe Ser Gln Phe Ile Glu Glu Cys Ser Phe Gly 
    210                 215                 220                 


Ser Ala Arg His Ala Ala Leu Glu Phe Phe Asp Ser Cys Val Glu Lys 
225                 230                 235                 240 


Val His Pro Glu Gln Glu Lys Pro Glu Pro Thr Pro Leu Val Glu Leu 
                245                 250                 255     


Glu Glu Leu Ser Gly Ser Glu Leu Thr Val Phe Ile Thr Pro Pro Glu 
            260                 265                 270         


Glu Pro Ala Leu Pro Glu Gly Ser Glu Ser Thr Pro Gln Tyr Cys Tyr 
        275                 280                 285             


Asp Gly Phe Pro Glu Leu Arg Ala Glu Leu Phe Glu Ser Leu Gln Glu 
    290                 295                 300                 


Gln Pro Gly Ala Leu Pro Val Pro Gly Pro Ser Arg Ser Ala Pro Ser 
305                 310                 315                 320 


Ser Pro Ala Pro Arg Arg Thr Lys Gln Glu Met Lys Val Ala Gln Arg 
                325                 330                 335     


Met Ala Gln Lys Ser Ala Ala Val Pro Glu Leu Trp Ala Arg Cys Leu 
            340                 345                 350         


Leu Gly His Cys Tyr Gly Leu Trp Phe Leu Cys Leu Pro Ala Tyr Val 
        355                 360                 365             


Arg Ser Ala Pro Ser Arg Val Gln Ala Leu His Thr Ala Tyr His Val 
    370                 375                 380                 


Leu Arg Gln Met Glu Ser Gly Lys Val Val Leu Pro Asp Glu Val Cys 
385                 390                 395                 400 


Tyr Arg Val Leu Met Gln Leu Cys Ser His Tyr Gly Gln Pro Val Leu 
                405                 410                 415     


Ser Val Arg Val Met Leu Glu Met Arg Gln Ala Gly Ile Val Pro Asn 
            420                 425                 430         


Thr Ile Thr Tyr Gly Tyr Tyr Asn Lys Ala Val Leu Glu Ser Lys Trp 
        435                 440                 445             


Pro Ser Gly Thr Pro Gly Gly Arg Leu Arg Trp Ala Lys Leu Arg Asn 
    450                 455                 460                 


Val Val Leu Gly Ala Ala Gln Phe Arg Gln Pro Leu Arg Glu Arg Gln 
465                 470                 475                 480 


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Glu 
                485                 490                 495     


Gln Val Ser Ala His Gln Glu Ala Gly Ser Ser Gln Ala Glu Pro Tyr 
            500                 505                 510         


Leu Glu Arg Pro Ser Pro Thr Arg Pro Leu Gln Arg Gln Thr Thr Trp 
        515                 520                 525             


Ala Gly Arg Ser Leu Arg Asp Pro Ala Ser Pro Pro Gly Arg Leu Val 
    530                 535                 540                 


Lys Ser Gly Ser Leu Gly Ser Ala Arg Gly Ala Gln Pro Thr Val Glu 
545                 550                 555                 560 


Ala Gly Val Ala His Met Ile Glu Ala Leu Gly Val Leu Glu Pro Arg 
                565                 570                 575     


Gly Ser Pro Val Pro Trp His Asp Gly Ser Leu Ser Asp Leu Ser Leu 
            580                 585                 590         


Thr Gly Glu Glu Pro Leu Pro Gly Gly Ser Pro Gly Gly Ser Gly Ser 
        595                 600                 605             


Ala Leu Ser Ala Gln Ser Thr Glu Ala Leu Glu Gly Leu Ser Gly Arg 
    610                 615                 620                 


Gly Pro Lys Ala Gly Gly Arg Gln Asp Glu Ala Gly Thr Pro Arg Arg 
625                 630                 635                 640 


Gly Leu Gly Ala Arg Leu Gln Gln Leu Leu Thr Pro Ser Arg His Ser 
                645                 650                 655     


Pro Ala Ser Arg Ile Pro Pro Pro Glu Leu Pro Pro Asp Leu Pro Pro 
            660                 665                 670         


Pro Ala Arg Arg Ser Pro Met Asp Ser Leu Leu His Pro Arg Glu Arg 
        675                 680                 685             


Pro Gly Ser Thr Ala Ser Glu Ser Ser Ala Ser Leu Gly Ser Glu Trp 
    690                 695                 700                 


Asp Leu Ser Glu Ser Ser Leu Ser Asn Leu Ser Leu Arg Arg Ser Ser 
705                 710                 715                 720 


Glu Arg Leu Ser Asp Thr Pro Gly Ser Phe Gln Ser Pro Ser Leu Glu 
                725                 730                 735     


Ile Leu Leu Ser Ser Cys Ser Leu Cys Arg Ala Cys Asp Ser Leu Val 
            740                 745                 750         


Tyr Asp Glu Glu Ile Met Ala Gly Trp Ala Pro Asp Asp Ser Asn Leu 
        755                 760                 765             


Asn Thr Thr Cys Pro Phe Cys Ala Cys Pro Phe Val Pro Leu Leu Ser 
    770                 775                 780                 


Val Gln Thr Leu Asp Ser Arg Pro Ser Val Pro Ser Pro Lys Ser Ala 
785                 790                 795                 800 


Gly Ala Ser Gly Ser Lys Asp Ala Pro Val Pro Gly Gly Pro Gly Pro 
                805                 810                 815     


Val Leu Ser Asp Arg Arg Leu Cys Leu Ala Leu Asp Glu Pro Gln Leu 
            820                 825                 830         


Cys Asn Gly His Met Gly Gly Ala Ser Arg Arg Val Glu Ser Gly Ala 
        835                 840                 845             


Trp Ala Tyr Leu Ser Pro Leu Val Leu Arg Lys Glu Leu Glu Ser Leu 
    850                 855                 860                 


Val Glu Asn Glu Gly Ser Glu Val Leu Ala Leu Pro Glu Leu Pro Ser 
865                 870                 875                 880 


Ala His Pro Ile Ile Phe Trp Asn Leu Leu Trp Tyr Phe Gln Arg Leu 
                885                 890                 895     


Arg Leu Pro Ser Ile Leu Pro Gly Leu Val Leu Ala Ser Cys Asp Gly 
            900                 905                 910         


Pro Ser His Ser Gln Ala Pro Ser Pro Trp Leu Thr Pro Asp Pro Ala 
        915                 920                 925             


Ser Val Gln Val Arg Leu Leu Trp Asp Val Leu Thr Pro Asp Pro Asn 
    930                 935                 940                 


Ser Cys Pro Pro Leu Tyr Val Leu Trp Arg Val His Ser Gln Ile Pro 
945                 950                 955                 960 


Gln Arg Val Val Trp Pro Gly Pro Val Pro Ala Ser Leu Ser Leu Ala 
                965                 970                 975     


Leu Leu Glu Ser Val Leu Arg His Val Gly Leu Asn Glu Val His Lys 
            980                 985                 990         


Ala Val Gly Leu Leu Leu Glu Thr  Leu Gly Pro Pro Pro  Thr Gly Leu 
        995                 1000                 1005             


His Leu  Gln Arg Gly Ile Tyr  Arg Glu Ile Leu Phe  Leu Thr Met 
    1010                 1015                 1020             


Ala Ala  Leu Gly Lys Asp His  Val Asp Ile Val Ala  Phe Asp Lys 
    1025                 1030                 1035             


Lys Tyr  Lys Ser Ala Phe Asn  Lys Leu Ala Ser Ser  Met Gly Lys 
    1040                 1045                 1050             


Glu Glu  Leu Arg His Arg Arg  Ala Gln Met Pro Thr  Pro Lys Ala 
    1055                 1060                 1065             


Ile Asp  Cys Arg Lys Cys Phe  Gly Ala Pro Pro Glu  Cys 
    1070                 1075                 1080     

<210>  750
<211>  5300
<212>  DNA
<213>  Homo sapiens

<400>  750
ctgaggaaac gtgggttcct gaacccagtg ggcccctgcg ccctccccgg ccagctgagc     60

ccatcacaga tgtggcagtc atcgctaggg cactgggcga ggaagtgccc cagggctaca    120

catgcatcca ggcttctgct gggggccacc ccttggaact cagtgctgga cttctgggtg    180

gaactcaacc cgtcatctgc taccgcaggg gccgtgacaa gccccccctc gttgagctgg    240

gggtgttgta tgaggggaag gaacgtccca agcctggctt ccaagtgctt gacacgacac    300

cctacagcca ctcagcaaac ctggcccctc caggccccgg gcacccccgc acctacctca    360

cttaccggcg ggcagcagag ggggcagggc tgcatgccct gggcatcact gacctctgcc    420

tggtgctgcc cagtaagggc gagggcactc ctcatactta ctgccggctg ccccgcaacc    480

tcaaccctgg catgtggggc ccagcagtgt acctgtgcta taaggtgggc ctggcgaagg    540

ccaacacgct ggtgtacgag gcagagctgc tgggccgcta cccggaggag gacaatgagg    600

cgttcccgct gcccgagtca gtgcccgtct tctgcctgcc catgggggcc actatcgagt    660

gctggcctgc ccagaccaag taccccgtgc ccgtcttctc cacctttgtg ctcacgggtg    720

cagctggtga taaggtgtat ggtgccgccc tgcagttcta cgaggcgttc ccaagggcca    780

ggctatcaga gcgacaggca cgggcactgg gcctgctgag cgccgtggag cggggtcggg    840

cactgggggg cagagctgtg cgcagccggc gtgccatcgc tgtgctgtcc cgctggcctg    900

ccttccctgc cttccgcgcc ttcctcacct tcctttaccg ctactccgtc tcaggccccc    960

accgcctacc cttggaagcg cacatctccc acttcattca caacgttccc ttcccttccc   1020

cacagagacc ccgcatccta gtgcagatgt ctccctatga caacttgctc ctctgtcagc   1080

ctgtatcctc acccctgccc ctcagtggtg ccagcttcct gcagctgctg cagagcctgg   1140

gccctgagct ggctatcaca ctgctgctgg ctgtgctcac agagcacaag ctgctagtcc   1200

actcgctgcg gccagacctg ctcaccagcg tctgtgaggc cctcgtctcg atgatcttcc   1260

cactgcactg gcagtgcccc tacattcctc tgtgcccgct ggtgctggca gatgtgctga   1320

gtgccccagt gcccttcatt gtgggtatcc actccagcta ctttgatctg catgacccgc   1380

ctgctgatgt catctgtgta gaccttgata ccaacacgct cttccagact gaggaaaaga   1440

agctcctctc ccctcggacc ctgccccgca gaccctacaa ggttctgctg gccacactga   1500

caaacctgta ccagcagctg gaccagacat acactggacc tgaggaggaa gcatccctgg   1560

agttcctact gacagactac gaggcagtgt gtggccgcag ggcccggctg gagcgcgaag   1620

tccaaggagc cttcctccgc ttcatggcct gtctgctcaa gggctaccgg gtcttcctgc   1680

gcccactcac ccaggccccc tccgagggag ctcgtgatgt tgacaacctt ttcttcctgc   1740

agggcttcct caaatcccgg gaacgctcca gccacaaact ttactctcag ctgctgcaca   1800

cacagatgtt ctcacagttc attgaggagt gctcttttgg ctctgctcgc catgctgccc   1860

ttgaattctt tgactcttgt gttgaaaagg tccacccaga gcaggagaag cctgagccga   1920

cacccttagt ggagctagag gagctgtcag gaagtgagct cactgtcttt atcacacctc   1980

ccgaggagcc tgccttacca gagggcagtg aatccactcc ccagtactgc tatgatggat   2040

tcccagagct acgggctgag ttgtttgagt ctcttcaaga gcaacctggg gccctgcctg   2100

tgccaggccc ttcccgtagc gcccccagca gtcctgctcc tcgccgtacc aaacaggaga   2160

tgaaagttgc acagcggatg gcacagaagt cagcagctgt gcctgagctg tgggcccggt   2220

gcctgctggg gcactgctat gggctgtggt tcctgtgtct gcctgcctat gtgcggtcgg   2280

caccctcccg agtgcaggca ctgcacacag cctaccatgt gctgcgccag atggagagcg   2340

gcaaggtggt gctccctgat gaggtgtgtt accgggtact gatgcagctc tgctcacact   2400

atgggcagcc tgtgctgtct gtgcgggtca tgctggagat gcgtcaggca ggcattgtgc   2460

ccaacaccat cacctatggc tactacaata aggctgtgtt ggaaagcaag tggccgtctg   2520

gcacaccagg tgggcgtctg cgctgggcca agctccggaa tgttgtcctg ggggctgctc   2580

agttccgcca gcccttgaga gaacggcaac agcagcagca gcagcaacag cagcagcagc   2640

agcagcagca gcaggagcag gtgtcagcac atcaagaggc aggcagctcc caggcagagc   2700

cctatttgga gcgcccttcc cctactcgcc ctcttcagcg ccagactact tgggctgggc   2760

gaagtctgag agacccagcc tcaccccctg gacgcctggt gaagagtggt agcctgggca   2820

gtgcccgagg ggcacagccc actgtggagg ccggtgtggc ccacatgata gaggccttgg   2880

gggtcctgga accccgggga tcacctgtgc cctggcacga tggaagtctc tcagacctga   2940

gcctgacagg ggaggagccg ctccctggag gcagcccagg gggctcaggc tcagccctga   3000

gtgcccagtc cactgaggcc ctggaagggc taagtgggcg gggacccaag gctggtgggc   3060

gacaggatga ggcaggcacc ccccgacgag ggctgggtgc ccgcctccaa cagctgctca   3120

ctccttcccg ccactcccct gcctcccgca ttcccccacc tgagctgcct cctgacctgc   3180

cacccccagc ccgccgcagc cccatggaca gtcttctgca cccccgggag cgccctggat   3240

ccactgcctc cgagagctca gcctctctgg gcagtgagtg ggacctctca gaatcttctc   3300

tcagcaacct gagtcttcgc cgttcctcag agcgcctcag tgacacccct ggatccttcc   3360

agtcaccttc cctggaaatt ctgctgtcca gctgctccct gtgccgtgcc tgtgattcgc   3420

tggtgtatga tgaggaaatc atggctggct gggcacctga tgactctaac ctcaacacaa   3480

cctgcccctt ctgcgcctgc ccctttgtgc ccctgctcag tgtccagacc cttgattccc   3540

ggcccagtgt ccccagcccc aaatctgctg gtgccagtgg cagcaaagat gctcctgtcc   3600

ctggtggtcc tggccctgtg ctcagtgacc gaaggctctg ccttgctctg gatgagcccc   3660

agctctgcaa cgggcacatg gggggagcct cccggcgggt tgagagtggg gcatgggcat   3720

acctgagccc cctggtgctg cgtaaggagc tggagtcgct ggtagagaac gagggcagtg   3780

aggtgctggc gttgcctgaa ctgccctctg cccaccccat catcttctgg aaccttttgt   3840

ggtatttcca acggctacgc ctgcccagta ttctaccagg cctggtgctg gcctcctgtg   3900

atgggccttc gcactcccag gccccatctc cttggctaac ccctgatcca gcctctgttc   3960

aggtacggct gctgtgggat gtactgaccc ctgaccccaa tagctgccca cctctctatg   4020

tgctctggag ggtccacagt gagtctggta tttggcctgg gtggggaggg tgggtcccat   4080

acccagaggg ctcagtgatt ctggtggcct tctttccttt catccaggcc agatccccca   4140

gcgggtggta tggccaggcc ctgtacctgc atcccttagt ttggcactgt tggagtcagt   4200

gctgcgccat gttggactca atgaagtgca caaggctgtg gggctcctgc tggaaactct   4260

agggccccca cccactggcc tgcacctgca gaggggaatc taccgtgaga tattattcct   4320

gacaatggct gctctgggca aggaccacgt ggacatagtg gccttcgata agaagtacaa   4380

gtctgccttt aacaagctgg ccagcagcat gggcaaggag gagctgaggc accggcgggc   4440

gcagatgccc actcccaagg ccattgactg ccgaaaatgt tttggagcac ctccagaatg   4500

ctagagacct taagcttccc tctccagcct agggtgggga agtgaggaag aagggattct   4560

agagttaaac tgcttccctg ttgccttcat ggagttggga acaggctggg aaggatgccc   4620

agtcaaaggc tccaagcgag gacaacagga agagggatcc actgttacca aaagtcctga   4680

ttcccccatc accaacctac ccagtttgtt cgtgctgatg ttgggggaga tctgggggga   4740

gttggtacag ctctgttctt cccttgtcct ataccgggaa ctcccctcca gggtacccac   4800

agatctgcat tgccctggtc attttagaag tttttgtttt aaaaaacaac tggaaagatg   4860

cagagctact gagcctttgc cctgaatggg aggtagggat gtcattctcc accaataatg   4920

gtccctcttc cctgacgttg ctgaaggagc ccaaggctct ccatgccttt ctacctaagt   4980

gtttgtattt tattttaaat tatttattct ggagccacag cccccttgct tatgaggttc   5040

ttatggagag tgagaaaggg aagggaaata gggcaccatg gtccggtggt ttgtagttcc   5100

ttcaaagtca ggcactggga gctagaggag tctcaagctc cccttaggaa gaactggtgc   5160

cccctccagt cctaattttt cttgcctgcc ccgccttggg gaatgcctca cccacccagg   5220

tcctgacctg tgcaataagg attgttccct gcgaagtttt gttggatgta aatatagtaa   5280

aagctgcttc tgtctttttc                                               5300


<210>  751
<211>  1256
<212>  PRT
<213>  Homo sapiens

<400>  751


Met Trp Gly Pro Ala Val Tyr Leu Cys Tyr Lys Val Gly Leu Ala Lys 
1               5                   10                  15      


Ala Asn Thr Leu Val Tyr Glu Ala Glu Leu Leu Gly Arg Tyr Pro Glu 
            20                  25                  30          


Glu Asp Asn Glu Ala Phe Pro Leu Pro Glu Ser Val Pro Val Phe Cys 
        35                  40                  45              


Leu Pro Met Gly Ala Thr Ile Glu Cys Trp Pro Ala Gln Thr Lys Tyr 
    50                  55                  60                  


Pro Val Pro Val Phe Ser Thr Phe Val Leu Thr Gly Ala Ala Gly Asp 
65                  70                  75                  80  


Lys Val Tyr Gly Ala Ala Leu Gln Phe Tyr Glu Ala Phe Pro Arg Ala 
                85                  90                  95      


Arg Leu Ser Glu Arg Gln Ala Arg Ala Leu Gly Leu Leu Ser Ala Val 
            100                 105                 110         


Glu Arg Gly Arg Ala Leu Gly Gly Arg Ala Val Arg Ser Arg Arg Ala 
        115                 120                 125             


Ile Ala Val Leu Ser Arg Trp Pro Ala Phe Pro Ala Phe Arg Ala Phe 
    130                 135                 140                 


Leu Thr Phe Leu Tyr Arg Tyr Ser Val Ser Gly Pro His Arg Leu Pro 
145                 150                 155                 160 


Leu Glu Ala His Ile Ser His Phe Ile His Asn Val Pro Phe Pro Ser 
                165                 170                 175     


Pro Gln Arg Pro Arg Ile Leu Val Gln Met Ser Pro Tyr Asp Asn Leu 
            180                 185                 190         


Leu Leu Cys Gln Pro Val Ser Ser Pro Leu Pro Leu Ser Gly Ala Ser 
        195                 200                 205             


Phe Leu Gln Leu Leu Gln Ser Leu Gly Pro Glu Leu Ala Ile Thr Leu 
    210                 215                 220                 


Leu Leu Ala Val Leu Thr Glu His Lys Leu Leu Val His Ser Leu Arg 
225                 230                 235                 240 


Pro Asp Leu Leu Thr Ser Val Cys Glu Ala Leu Val Ser Met Ile Phe 
                245                 250                 255     


Pro Leu His Trp Gln Cys Pro Tyr Ile Pro Leu Cys Pro Leu Val Leu 
            260                 265                 270         


Ala Asp Val Leu Ser Ala Pro Val Pro Phe Ile Val Gly Ile His Ser 
        275                 280                 285             


Ser Tyr Phe Asp Leu His Asp Pro Pro Ala Asp Val Ile Cys Val Asp 
    290                 295                 300                 


Leu Asp Thr Asn Thr Leu Phe Gln Thr Glu Glu Lys Lys Leu Leu Ser 
305                 310                 315                 320 


Pro Arg Thr Leu Pro Arg Arg Pro Tyr Lys Val Leu Leu Ala Thr Leu 
                325                 330                 335     


Thr Asn Leu Tyr Gln Gln Leu Asp Gln Thr Tyr Thr Gly Pro Glu Glu 
            340                 345                 350         


Glu Ala Ser Leu Glu Phe Leu Leu Thr Asp Tyr Glu Ala Val Cys Gly 
        355                 360                 365             


Arg Arg Ala Arg Leu Glu Arg Glu Val Gln Gly Ala Phe Leu Arg Phe 
    370                 375                 380                 


Met Ala Cys Leu Leu Lys Gly Tyr Arg Val Phe Leu Arg Pro Leu Thr 
385                 390                 395                 400 


Gln Ala Pro Ser Glu Gly Ala Arg Asp Val Asp Asn Leu Phe Phe Leu 
                405                 410                 415     


Gln Gly Phe Leu Lys Ser Arg Glu Arg Ser Ser His Lys Leu Tyr Ser 
            420                 425                 430         


Gln Leu Leu His Thr Gln Met Phe Ser Gln Phe Ile Glu Glu Cys Ser 
        435                 440                 445             


Phe Gly Ser Ala Arg His Ala Ala Leu Glu Phe Phe Asp Ser Cys Val 
    450                 455                 460                 


Glu Lys Val His Pro Glu Gln Glu Lys Pro Glu Pro Thr Pro Leu Val 
465                 470                 475                 480 


Glu Leu Glu Glu Leu Ser Gly Ser Glu Leu Thr Val Phe Ile Thr Pro 
                485                 490                 495     


Pro Glu Glu Pro Ala Leu Pro Glu Gly Ser Glu Ser Thr Pro Gln Tyr 
            500                 505                 510         


Cys Tyr Asp Gly Phe Pro Glu Leu Arg Ala Glu Leu Phe Glu Ser Leu 
        515                 520                 525             


Gln Glu Gln Pro Gly Ala Leu Pro Val Pro Gly Pro Ser Arg Ser Ala 
    530                 535                 540                 


Pro Ser Ser Pro Ala Pro Arg Arg Thr Lys Gln Glu Met Lys Val Ala 
545                 550                 555                 560 


Gln Arg Met Ala Gln Lys Ser Ala Ala Val Pro Glu Leu Trp Ala Arg 
                565                 570                 575     


Cys Leu Leu Gly His Cys Tyr Gly Leu Trp Phe Leu Cys Leu Pro Ala 
            580                 585                 590         


Tyr Val Arg Ser Ala Pro Ser Arg Val Gln Ala Leu His Thr Ala Tyr 
        595                 600                 605             


His Val Leu Arg Gln Met Glu Ser Gly Lys Val Val Leu Pro Asp Glu 
    610                 615                 620                 


Val Cys Tyr Arg Val Leu Met Gln Leu Cys Ser His Tyr Gly Gln Pro 
625                 630                 635                 640 


Val Leu Ser Val Arg Val Met Leu Glu Met Arg Gln Ala Gly Ile Val 
                645                 650                 655     


Pro Asn Thr Ile Thr Tyr Gly Tyr Tyr Asn Lys Ala Val Leu Glu Ser 
            660                 665                 670         


Lys Trp Pro Ser Gly Thr Pro Gly Gly Arg Leu Arg Trp Ala Lys Leu 
        675                 680                 685             


Arg Asn Val Val Leu Gly Ala Ala Gln Phe Arg Gln Pro Leu Arg Glu 
    690                 695                 700                 


Arg Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
705                 710                 715                 720 


Gln Glu Gln Val Ser Ala His Gln Glu Ala Gly Ser Ser Gln Ala Glu 
                725                 730                 735     


Pro Tyr Leu Glu Arg Pro Ser Pro Thr Arg Pro Leu Gln Arg Gln Thr 
            740                 745                 750         


Thr Trp Ala Gly Arg Ser Leu Arg Asp Pro Ala Ser Pro Pro Gly Arg 
        755                 760                 765             


Leu Val Lys Ser Gly Ser Leu Gly Ser Ala Arg Gly Ala Gln Pro Thr 
    770                 775                 780                 


Val Glu Ala Gly Val Ala His Met Ile Glu Ala Leu Gly Val Leu Glu 
785                 790                 795                 800 


Pro Arg Gly Ser Pro Val Pro Trp His Asp Gly Ser Leu Ser Asp Leu 
                805                 810                 815     


Ser Leu Thr Gly Glu Glu Pro Leu Pro Gly Gly Ser Pro Gly Gly Ser 
            820                 825                 830         


Gly Ser Ala Leu Ser Ala Gln Ser Thr Glu Ala Leu Glu Gly Leu Ser 
        835                 840                 845             


Gly Arg Gly Pro Lys Ala Gly Gly Arg Gln Asp Glu Ala Gly Thr Pro 
    850                 855                 860                 


Arg Arg Gly Leu Gly Ala Arg Leu Gln Gln Leu Leu Thr Pro Ser Arg 
865                 870                 875                 880 


His Ser Pro Ala Ser Arg Ile Pro Pro Pro Glu Leu Pro Pro Asp Leu 
                885                 890                 895     


Pro Pro Pro Ala Arg Arg Ser Pro Met Asp Ser Leu Leu His Pro Arg 
            900                 905                 910         


Glu Arg Pro Gly Ser Thr Ala Ser Glu Ser Ser Ala Ser Leu Gly Ser 
        915                 920                 925             


Glu Trp Asp Leu Ser Glu Ser Ser Leu Ser Asn Leu Ser Leu Arg Arg 
    930                 935                 940                 


Ser Ser Glu Arg Leu Ser Asp Thr Pro Gly Ser Phe Gln Ser Pro Ser 
945                 950                 955                 960 


Leu Glu Ile Leu Leu Ser Ser Cys Ser Leu Cys Arg Ala Cys Asp Ser 
                965                 970                 975     


Leu Val Tyr Asp Glu Glu Ile Met Ala Gly Trp Ala Pro Asp Asp Ser 
            980                 985                 990         


Asn Leu Asn Thr Thr Cys Pro Phe  Cys Ala Cys Pro Phe  Val Pro Leu 
        995                 1000                 1005             


Leu Ser  Val Gln Thr Leu Asp  Ser Arg Pro Ser Val  Pro Ser Pro 
    1010                 1015                 1020             


Lys Ser  Ala Gly Ala Ser Gly  Ser Lys Asp Ala Pro  Val Pro Gly 
    1025                 1030                 1035             


Gly Pro  Gly Pro Val Leu Ser  Asp Arg Arg Leu Cys  Leu Ala Leu 
    1040                 1045                 1050             


Asp Glu  Pro Gln Leu Cys Asn  Gly His Met Gly Gly  Ala Ser Arg 
    1055                 1060                 1065             


Arg Val  Glu Ser Gly Ala Trp  Ala Tyr Leu Ser Pro  Leu Val Leu 
    1070                 1075                 1080             


Arg Lys  Glu Leu Glu Ser Leu  Val Glu Asn Glu Gly  Ser Glu Val 
    1085                 1090                 1095             


Leu Ala  Leu Pro Glu Leu Pro  Ser Ala His Pro Ile  Ile Phe Trp 
    1100                 1105                 1110             


Asn Leu  Leu Trp Tyr Phe Gln  Arg Leu Arg Leu Pro  Ser Ile Leu 
    1115                 1120                 1125             


Pro Gly  Leu Val Leu Ala Ser  Cys Asp Gly Pro Ser  His Ser Gln 
    1130                 1135                 1140             


Ala Pro  Ser Pro Trp Leu Thr  Pro Asp Pro Ala Ser  Val Gln Val 
    1145                 1150                 1155             


Arg Leu  Leu Trp Asp Val Leu  Thr Pro Asp Pro Asn  Ser Cys Pro 
    1160                 1165                 1170             


Pro Leu  Tyr Val Leu Trp Arg  Val His Ser Glu Ser  Gly Ile Trp 
    1175                 1180                 1185             


Pro Gly  Trp Gly Gly Trp Val  Pro Tyr Pro Glu Gly  Ser Val Ile 
    1190                 1195                 1200             


Leu Val  Ala Phe Phe Pro Phe  Ile Gln Ala Arg Ser  Pro Ser Gly 
    1205                 1210                 1215             


Trp Tyr  Gly Gln Ala Leu Tyr  Leu His Pro Leu Val  Trp His Cys 
    1220                 1225                 1230             


Trp Ser  Gln Cys Cys Ala Met  Leu Asp Ser Met Lys  Cys Thr Arg 
    1235                 1240                 1245             


Leu Trp  Gly Ser Cys Trp Lys  Leu 
    1250                 1255     

<210>  752
<211>  2140
<212>  DNA
<213>  Homo sapiens

<400>  752
atggcggagg agcggccccc ccggctggtg gattacttcg tggtagctgg gcttgcaggg     60

aacggagcac ccatccctga ggaaacgtgg gttcctgaac ccagtgggcc cctgcgccct    120

ccccggccag ctgagcccat cacagatgtg gcagtcatcg ctagggcact gggcgaggaa    180

gtgccccagg gctacacatg catccaggct tctgctgggg gccacccctt ggaactcagt    240

gctggacttc tgggtggaac tcaacccgtc atctgctacc gcaggggccg tgacaagccc    300

cccctcgttg agctgggggt gttgtatgag gggaaggaac gtcccaagcc tggcttccaa    360

gtgcttgaca cgacacccta cagccactca gcaaacctgg cccctccagg ccccgggcac    420

ccccgcacct acctcactta ccggcgggca gcagaggggg cagggctgca tgccctgggc    480

atcactgacc tctgcctggt gctgcccagt aagggcgagg gcactcctca tacttactgc    540

cggctgcccc gcaacctcaa ccctggcatg tggggcccag cagtgtacct gtgctataag    600

gtgggcctgg cgaaggccaa cacgctggtg tacgaggcag gtgagtggcc cctttatccc    660

tccaatcctg tgaccctaca tccctttgcc ctggtgcctc ttggcaggca ccttaagtgt    720

ccccagagtt tactttctct ttgctactcg ggccttctct gggatccctt ggttcatttc    780

ccttggagtc tgatggaccc tgctcctttt gggtaccccc aactatgctg ggggtgcaga    840

gctgctgggc cgctacccgg aggaggacaa tgaggcgttc ccgctgcccg agtcagtgcc    900

cgtcttctgc ctgcccatgg gggccactat cgagtgctgg cctgcccaga ccaagtaccc    960

cgtgcccgtc ttctccacct ttgtgctcac gggtgcagct ggtgataagg tgtatggtgc   1020

cgccctgcag ttctacgagg cgttcccaag ggccaggcta tcagagcgac aggcacgggc   1080

actgggcctg ctgagcgccg tggagcgggg tcgggcactg gggggcagag ctgtgcgcag   1140

ccggcgtgcc atcgctgtgc tgtcccgctg gcctgccttc cctgccttcc gcgccttcct   1200

caccttcctt taccgctact ccgtctcagg cccccaccgc ctacccttgg aagcgcacat   1260

ctcccacttc attcacaacg ttcccttccc ttccccacag agaccccgca tcctagtgca   1320

gatgtctccc tatgacaact tgctcctctg tcagcctgta tcctcacccc tgcccctcag   1380

tggtgccagc ttcctgcagc tgctgcagag cctgggccct gagctggcta tcacactgct   1440

gctggctgtg ctcacagagc acaagctgct agtccactcg ctgcggccag acctgctcac   1500

cagcgtctgt gaggccctcg tctcgatgat cttcccactg cactggcagt gcccctacat   1560

tcctctgtgc ccgctggtgc tggcagatgt gctgagtgcc ccagtgccct tcattgtggg   1620

tatccactcc agctactttg atctgcatga cccgcctgct gatgtcatct gtgtagacct   1680

tgataccaac acgctcttcc agactgagga aaagaagctc ctctcccctc ggaccctgcc   1740

ccgcagaccc tacaaggttc tgctggccac actgacaaac ctgtaccagc agctggacca   1800

gacatacact ggacctaagt gtttgtattt tattttaaat tatttattct ggagccacag   1860

cccccttgct tatgaggttc ttatggagag tgagaaaggg aagggaaata gggcaccatg   1920

gtccggtggt ttgtagttcc ttcaaagtca ggcactggga gctagaggag tctcaagctc   1980

cccttaggaa gaactggtgc cccctccagt cctaattttt cttgcctgcc ccgccttggg   2040

gaatgcctca cccacccagg tcctgacctg tgcaataagg attgttccct gcgaagtttt   2100

gttggatgta aatatagtaa aagctgcttc tgtctttttc                         2140


<210>  753
<211>  339
<212>  PRT
<213>  Homo sapiens

<400>  753


Met Gly Ala Thr Ile Glu Cys Trp Pro Ala Gln Thr Lys Tyr Pro Val 
1               5                   10                  15      


Pro Val Phe Ser Thr Phe Val Leu Thr Gly Ala Ala Gly Asp Lys Val 
            20                  25                  30          


Tyr Gly Ala Ala Leu Gln Phe Tyr Glu Ala Phe Pro Arg Ala Arg Leu 
        35                  40                  45              


Ser Glu Arg Gln Ala Arg Ala Leu Gly Leu Leu Ser Ala Val Glu Arg 
    50                  55                  60                  


Gly Arg Ala Leu Gly Gly Arg Ala Val Arg Ser Arg Arg Ala Ile Ala 
65                  70                  75                  80  


Val Leu Ser Arg Trp Pro Ala Phe Pro Ala Phe Arg Ala Phe Leu Thr 
                85                  90                  95      


Phe Leu Tyr Arg Tyr Ser Val Ser Gly Pro His Arg Leu Pro Leu Glu 
            100                 105                 110         


Ala His Ile Ser His Phe Ile His Asn Val Pro Phe Pro Ser Pro Gln 
        115                 120                 125             


Arg Pro Arg Ile Leu Val Gln Met Ser Pro Tyr Asp Asn Leu Leu Leu 
    130                 135                 140                 


Cys Gln Pro Val Ser Ser Pro Leu Pro Leu Ser Gly Ala Ser Phe Leu 
145                 150                 155                 160 


Gln Leu Leu Gln Ser Leu Gly Pro Glu Leu Ala Ile Thr Leu Leu Leu 
                165                 170                 175     


Ala Val Leu Thr Glu His Lys Leu Leu Val His Ser Leu Arg Pro Asp 
            180                 185                 190         


Leu Leu Thr Ser Val Cys Glu Ala Leu Val Ser Met Ile Phe Pro Leu 
        195                 200                 205             


His Trp Gln Cys Pro Tyr Ile Pro Leu Cys Pro Leu Val Leu Ala Asp 
    210                 215                 220                 


Val Leu Ser Ala Pro Val Pro Phe Ile Val Gly Ile His Ser Ser Tyr 
225                 230                 235                 240 


Phe Asp Leu His Asp Pro Pro Ala Asp Val Ile Cys Val Asp Leu Asp 
                245                 250                 255     


Thr Asn Thr Leu Phe Gln Thr Glu Glu Lys Lys Leu Leu Ser Pro Arg 
            260                 265                 270         


Thr Leu Pro Arg Arg Pro Tyr Lys Val Leu Leu Ala Thr Leu Thr Asn 
        275                 280                 285             


Leu Tyr Gln Gln Leu Asp Gln Thr Tyr Thr Gly Pro Lys Cys Leu Tyr 
    290                 295                 300                 


Phe Ile Leu Asn Tyr Leu Phe Trp Ser His Ser Pro Leu Ala Tyr Glu 
305                 310                 315                 320 


Val Leu Met Glu Ser Glu Lys Gly Lys Gly Asn Arg Ala Pro Trp Ser 
                325                 330                 335     


Gly Gly Leu 
            

<210>  754
<211>  5410
<212>  DNA
<213>  Homo sapiens

<400>  754
atggcggagg agcggccccc ccggctggtg gattacttcg tggtagctgg gcttgcaggg     60

aacggagcac ccatccctga ggaaacgtgg gttcctgaac ccagtgggcc cctgcgccct    120

ccccggccag ctgagcccat cacagatgtg gcagtcatcg ctagggcact gggcgaggaa    180

gtgccccagg gctacacatg catccaggct tctgctgggg gccacccctt ggaactcagt    240

gctggacttc tgggtggaac tcaacccgtc atctgctacc gcaggggccg tgacaagccc    300

cccctcgttg agctgggggt gttgtatgag gggaaggaac gtcccaagcc tggcttccaa    360

gtgcttgaca cgacacccta cagccactca gcaaacctgg cccctccagg ccccgggcac    420

ccccgcacct acctcactta ccggcgggca gcagaggggg cagggctgca tgccctgggc    480

atcactgacc tctgcctggt gctgcccagt aagggcgagg gcactcctca tacttactgc    540

cggctgcccc gcaacctcaa ccctggcatg tggggcccag cagtgtacct gtgctataag    600

gtgggcctgg cgaaggccaa cacgctggtg tacgaggcag gtgagtggcc cctttatccc    660

tccaatcctg tgaccctaca tccctttgcc ctggtgcctc ttggcaggca ccttaagtgt    720

ccccagagtt tactttctct ttgctactcg ggccttctct gggatccctt ggttcatttc    780

ccttggagtc tgatggaccc tgctcctttt gggtaccccc aactatgctg ggggtgcaga    840

gctgctgggc cgctacccgg aggaggacaa tgaggcgttc ccgctgcccg agtcagtgcc    900

cgtcttctgc ctgcccatgg gggccactat cgagtgctgg cctgcccaga ccaagtaccc    960

cgtgcccgtc ttctccacct ttgtgctcac gggtgcagct ggtgataagg tgtatggtgc   1020

cgccctgcag ttctacgagg cgttcccaag ggccaggcta tcagagcgac aggcacgggc   1080

actgggcctg ctgagcgccg tggagcgggg tcgggcactg gggggcagag ctgtgcgcag   1140

ccggcgtgcc atcgctgtgc tgtcccgctg gcctgccttc cctgccttcc gcgccttcct   1200

caccttcctt taccgctact ccgtctcagg cccccaccgc ctacccttgg aagcgcacat   1260

ctcccacttc attcacaacg ttcccttccc ttccccacag agaccccgca tcctagtgca   1320

gatgtctccc tatgacaact tgctcctctg tcagcctgta tcctcacccc tgcccctcag   1380

tggtgccagc ttcctgcagc tgctgcagag cctgggccct gagctggcta tcacactgct   1440

gctggctgtg ctcacagagc acaagctgct agtccactcg ctgcggccag acctgctcac   1500

cagcgtctgt gaggccctcg tctcgatgat cttcccactg cactggcagt gcccctacat   1560

tcctctgtgc ccgctggtgc tggcagatgt gctgagtgcc ccagtgccct tcattgtggg   1620

tatccactcc agctactttg atctgcatga cccgcctgct gatgtcatct gtgtagacct   1680

tgataccaac acgctcttcc agactgagga aaagaagctc ctctcccctc ggaccctgcc   1740

ccgcagaccc tacaaggttc tgctggccac actgacaaac ctgtaccagc agctggacca   1800

gacatacact ggacctgagg aggaagcatc cctggagttc ctactgacag actacgaggc   1860

agtgtgtggc cgcagggccc ggctggagcg cgaagtccaa ggagccttcc tccgcttcat   1920

ggcctgtctg ctcaagggct accgggtctt cctgcgccca ctcacccagg ccccctccga   1980

gggagctcgt gatgttgaca accttttctt cctgcagggc ttcctcaaat cccgggaacg   2040

ctccagccac aaactttact ctcagctgct gcacacacag atgttctcac agttcattga   2100

ggagtgctct tttggctctg ctcgccatgc tgcccttgaa ttctttgact cttgtgttga   2160

aaaggtccac ccagagcagg agaagcctga gccgacaccc ttagtggagc tagaggagct   2220

gtcaggaagt gagctcactg tctttatcac acctcccgag gagcctgcct taccagaggg   2280

cagtgaatcc actccccagt actgctatga tggattccca gagctacggg ctgagttgtt   2340

tgagtctctt caagagcaac ctggggccct gcctgtgcca ggcccttccc gtagcgcccc   2400

cagcagtcct gctcctcgcc gtaccaaaca ggagatgaaa gttgcacagc ggatggcaca   2460

gaagtcagca gctgtgcctg agctgtgggc ccggtgcctg ctggggcact gctatgggct   2520

gtggttcctg tgtctgcctg cctatgtgcg gtcggcaccc tcccgagtgc aggcactgca   2580

cacagcctac catgtgctgc gccagatgga gagcggcaag gtggtgctcc ctgatgaggt   2640

gtgttaccgg gtactgatgc agctctgctc acactatggg cagcctgtgc tgtctgtgcg   2700

ggtcatgctg gagatgcgtc aggcaggcat tgtgcccaac accatcacct atggctacta   2760

caataaggct gtgttggaaa gcaagtggcc gtctggcaca ccaggtgggc gtctgcgctg   2820

ggccaagctc cggaatgttg tcctgggggc tgctcagttc cgccagccct tgagagaacg   2880

gcaacagcag cagcagcagc aacagcagca gcagcagcag cagcagcagg agcaggtgtc   2940

agcacatcaa gaggcaggca gctcccaggc agagccctat ttggagcgcc cttcccctac   3000

tcgccctctt cagcgccaga ctacttgggc tgggcgaagt ctgagagacc cagcctcacc   3060

ccctggacgc ctggtgaaga gtggtagcct gggcagtgcc cgaggggcac agcccactgt   3120

ggaggccggt gtggcccaca tgatagaggc cttgggggtc ctggaacccc ggggatcacc   3180

tgtgccctgg cacgatggaa gtctctcaga cctgagcctg acaggggagg agccgctccc   3240

tggaggcagc ccagggggct caggctcagc cctgagtgcc cagtccactg aggccctgga   3300

agggctaagt gggcggggac ccaaggctgg tgggcgacag gatgaggcag gcaccccccg   3360

acgagggctg ggtgcccgcc tccaacagct gctcactcct tcccgccact cccctgcctc   3420

ccgcattccc ccacctgagc tgcctcctga cctgccaccc ccagcccgcc gcagccccat   3480

ggacagtctt ctgcaccccc gggagcgccc tggatccact gcctccgaga gctcagcctc   3540

tctgggcagt gagtgggacc tctcagaatc ttctctcagc aacctgagtc ttcgccgttc   3600

ctcagagcgc ctcagtgaca cccctggatc cttccagtca ccttccctgg aaattctgct   3660

gtccagctgc tccctgtgcc gtgcctgtga ttcgctggtg tatgatgagg aaatcatggc   3720

tggctgggca cctgatgact ctaacctcaa cacaacctgc cccttctgcg cctgcccctt   3780

tgtgcccctg ctcagtgtcc agacccttga ttcccggccc agtgtcccca gccccaaatc   3840

tgctggtgcc agtggcagca aagatgctcc tgtccctggt ggtcctggcc ctgtgctcag   3900

tgaccgaagg ctctgccttg ctctggatga gccccagctc tgcaacgggc acatgggggg   3960

agcctcccgg cgggttgaga gtggggcatg ggcatacctg agccccctgg tgctgcgtaa   4020

ggagctggag tcgctggtag agaacgaggg cagtgaggtg ctggcgttgc ctgaactgcc   4080

ctctgcccac cccatcatct tctggaacct tttgtggtat ttccaacggc tacgcctgcc   4140

cagtattcta ccaggcctgg tgctggcctc ctgtgatggg ccttcgcact cccaggcccc   4200

atctccttgg ctaacccctg atccagcctc tgttcaggcc agatccccca gcgggtggta   4260

tggccaggcc ctgtacctgc atcccttagt ttggcactgt tggagtcagt gctgcgccat   4320

gttggactca atgaagtgca caaggctgtg gggctcctgc tggaaactct agggccccca   4380

cccactggcc tgcacctgca gaggggaatc taccgtgaga tattattcct gacaatggct   4440

gctctgggca aggaccacgt ggacatagtg gccttcgata agaagtacaa gtctgccttt   4500

aacaagctgg ccagcagcat gggcaaggag gagctgaggc accggcgggc gcagatgccc   4560

actcccaagg ccattgactg ccgaaaatgt tttggagcac ctccagaatg ctagagacct   4620

taagcttccc tctccagcct agggtgggga agtgaggaag aagggattct agagttaaac   4680

tgcttccctg ttgccttcat ggagttggga acaggctggg aaggatgccc agtcaaaggc   4740

tccaagcgag gacaacagga agagggatcc actgttacca aaagtcctga ttcccccatc   4800

accaacctac ccagtttgtt cgtgctgatg ttgggggaga tctgggggga gttggtacag   4860

ctctgttctt cccttgtcct ataccgggaa ctcccctcca gggtacccac agatctgcat   4920

tgccctggtc attttagaag tttttgtttt aaaaaacaac tggaaagatg cagagctact   4980

gagcctttgc cctgaatggg aggtagggat gtcattctcc accaataatg gtccctcttc   5040

cctgacgttg ctgaaggagc ccaaggctct ccatgccttt ctacctaagt gtttgtattt   5100

tattttaaat tatttattct ggagccacag cccccttgct tatgaggttc ttatggagag   5160

tgagaaaggg aagggaaata gggcaccatg gtccggtggt ttgtagttcc ttcaaagtca   5220

ggcactggga gctagaggag tctcaagctc cccttaggaa gaactggtgc cccctccagt   5280

cctaattttt cttgcctgcc ccgccttggg gaatgcctca cccacccagg tcctgacctg   5340

tgcaataagg attgttccct gcgaagtttt gttggatgta aatatagtaa aagctgcttc   5400

tgtctttttc                                                          5410


<210>  755
<211>  1151
<212>  PRT
<213>  Homo sapiens

<400>  755


Met Gly Ala Thr Ile Glu Cys Trp Pro Ala Gln Thr Lys Tyr Pro Val 
1               5                   10                  15      


Pro Val Phe Ser Thr Phe Val Leu Thr Gly Ala Ala Gly Asp Lys Val 
            20                  25                  30          


Tyr Gly Ala Ala Leu Gln Phe Tyr Glu Ala Phe Pro Arg Ala Arg Leu 
        35                  40                  45              


Ser Glu Arg Gln Ala Arg Ala Leu Gly Leu Leu Ser Ala Val Glu Arg 
    50                  55                  60                  


Gly Arg Ala Leu Gly Gly Arg Ala Val Arg Ser Arg Arg Ala Ile Ala 
65                  70                  75                  80  


Val Leu Ser Arg Trp Pro Ala Phe Pro Ala Phe Arg Ala Phe Leu Thr 
                85                  90                  95      


Phe Leu Tyr Arg Tyr Ser Val Ser Gly Pro His Arg Leu Pro Leu Glu 
            100                 105                 110         


Ala His Ile Ser His Phe Ile His Asn Val Pro Phe Pro Ser Pro Gln 
        115                 120                 125             


Arg Pro Arg Ile Leu Val Gln Met Ser Pro Tyr Asp Asn Leu Leu Leu 
    130                 135                 140                 


Cys Gln Pro Val Ser Ser Pro Leu Pro Leu Ser Gly Ala Ser Phe Leu 
145                 150                 155                 160 


Gln Leu Leu Gln Ser Leu Gly Pro Glu Leu Ala Ile Thr Leu Leu Leu 
                165                 170                 175     


Ala Val Leu Thr Glu His Lys Leu Leu Val His Ser Leu Arg Pro Asp 
            180                 185                 190         


Leu Leu Thr Ser Val Cys Glu Ala Leu Val Ser Met Ile Phe Pro Leu 
        195                 200                 205             


His Trp Gln Cys Pro Tyr Ile Pro Leu Cys Pro Leu Val Leu Ala Asp 
    210                 215                 220                 


Val Leu Ser Ala Pro Val Pro Phe Ile Val Gly Ile His Ser Ser Tyr 
225                 230                 235                 240 


Phe Asp Leu His Asp Pro Pro Ala Asp Val Ile Cys Val Asp Leu Asp 
                245                 250                 255     


Thr Asn Thr Leu Phe Gln Thr Glu Glu Lys Lys Leu Leu Ser Pro Arg 
            260                 265                 270         


Thr Leu Pro Arg Arg Pro Tyr Lys Val Leu Leu Ala Thr Leu Thr Asn 
        275                 280                 285             


Leu Tyr Gln Gln Leu Asp Gln Thr Tyr Thr Gly Pro Glu Glu Glu Ala 
    290                 295                 300                 


Ser Leu Glu Phe Leu Leu Thr Asp Tyr Glu Ala Val Cys Gly Arg Arg 
305                 310                 315                 320 


Ala Arg Leu Glu Arg Glu Val Gln Gly Ala Phe Leu Arg Phe Met Ala 
                325                 330                 335     


Cys Leu Leu Lys Gly Tyr Arg Val Phe Leu Arg Pro Leu Thr Gln Ala 
            340                 345                 350         


Pro Ser Glu Gly Ala Arg Asp Val Asp Asn Leu Phe Phe Leu Gln Gly 
        355                 360                 365             


Phe Leu Lys Ser Arg Glu Arg Ser Ser His Lys Leu Tyr Ser Gln Leu 
    370                 375                 380                 


Leu His Thr Gln Met Phe Ser Gln Phe Ile Glu Glu Cys Ser Phe Gly 
385                 390                 395                 400 


Ser Ala Arg His Ala Ala Leu Glu Phe Phe Asp Ser Cys Val Glu Lys 
                405                 410                 415     


Val His Pro Glu Gln Glu Lys Pro Glu Pro Thr Pro Leu Val Glu Leu 
            420                 425                 430         


Glu Glu Leu Ser Gly Ser Glu Leu Thr Val Phe Ile Thr Pro Pro Glu 
        435                 440                 445             


Glu Pro Ala Leu Pro Glu Gly Ser Glu Ser Thr Pro Gln Tyr Cys Tyr 
    450                 455                 460                 


Asp Gly Phe Pro Glu Leu Arg Ala Glu Leu Phe Glu Ser Leu Gln Glu 
465                 470                 475                 480 


Gln Pro Gly Ala Leu Pro Val Pro Gly Pro Ser Arg Ser Ala Pro Ser 
                485                 490                 495     


Ser Pro Ala Pro Arg Arg Thr Lys Gln Glu Met Lys Val Ala Gln Arg 
            500                 505                 510         


Met Ala Gln Lys Ser Ala Ala Val Pro Glu Leu Trp Ala Arg Cys Leu 
        515                 520                 525             


Leu Gly His Cys Tyr Gly Leu Trp Phe Leu Cys Leu Pro Ala Tyr Val 
    530                 535                 540                 


Arg Ser Ala Pro Ser Arg Val Gln Ala Leu His Thr Ala Tyr His Val 
545                 550                 555                 560 


Leu Arg Gln Met Glu Ser Gly Lys Val Val Leu Pro Asp Glu Val Cys 
                565                 570                 575     


Tyr Arg Val Leu Met Gln Leu Cys Ser His Tyr Gly Gln Pro Val Leu 
            580                 585                 590         


Ser Val Arg Val Met Leu Glu Met Arg Gln Ala Gly Ile Val Pro Asn 
        595                 600                 605             


Thr Ile Thr Tyr Gly Tyr Tyr Asn Lys Ala Val Leu Glu Ser Lys Trp 
    610                 615                 620                 


Pro Ser Gly Thr Pro Gly Gly Arg Leu Arg Trp Ala Lys Leu Arg Asn 
625                 630                 635                 640 


Val Val Leu Gly Ala Ala Gln Phe Arg Gln Pro Leu Arg Glu Arg Gln 
                645                 650                 655     


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Glu 
            660                 665                 670         


Gln Val Ser Ala His Gln Glu Ala Gly Ser Ser Gln Ala Glu Pro Tyr 
        675                 680                 685             


Leu Glu Arg Pro Ser Pro Thr Arg Pro Leu Gln Arg Gln Thr Thr Trp 
    690                 695                 700                 


Ala Gly Arg Ser Leu Arg Asp Pro Ala Ser Pro Pro Gly Arg Leu Val 
705                 710                 715                 720 


Lys Ser Gly Ser Leu Gly Ser Ala Arg Gly Ala Gln Pro Thr Val Glu 
                725                 730                 735     


Ala Gly Val Ala His Met Ile Glu Ala Leu Gly Val Leu Glu Pro Arg 
            740                 745                 750         


Gly Ser Pro Val Pro Trp His Asp Gly Ser Leu Ser Asp Leu Ser Leu 
        755                 760                 765             


Thr Gly Glu Glu Pro Leu Pro Gly Gly Ser Pro Gly Gly Ser Gly Ser 
    770                 775                 780                 


Ala Leu Ser Ala Gln Ser Thr Glu Ala Leu Glu Gly Leu Ser Gly Arg 
785                 790                 795                 800 


Gly Pro Lys Ala Gly Gly Arg Gln Asp Glu Ala Gly Thr Pro Arg Arg 
                805                 810                 815     


Gly Leu Gly Ala Arg Leu Gln Gln Leu Leu Thr Pro Ser Arg His Ser 
            820                 825                 830         


Pro Ala Ser Arg Ile Pro Pro Pro Glu Leu Pro Pro Asp Leu Pro Pro 
        835                 840                 845             


Pro Ala Arg Arg Ser Pro Met Asp Ser Leu Leu His Pro Arg Glu Arg 
    850                 855                 860                 


Pro Gly Ser Thr Ala Ser Glu Ser Ser Ala Ser Leu Gly Ser Glu Trp 
865                 870                 875                 880 


Asp Leu Ser Glu Ser Ser Leu Ser Asn Leu Ser Leu Arg Arg Ser Ser 
                885                 890                 895     


Glu Arg Leu Ser Asp Thr Pro Gly Ser Phe Gln Ser Pro Ser Leu Glu 
            900                 905                 910         


Ile Leu Leu Ser Ser Cys Ser Leu Cys Arg Ala Cys Asp Ser Leu Val 
        915                 920                 925             


Tyr Asp Glu Glu Ile Met Ala Gly Trp Ala Pro Asp Asp Ser Asn Leu 
    930                 935                 940                 


Asn Thr Thr Cys Pro Phe Cys Ala Cys Pro Phe Val Pro Leu Leu Ser 
945                 950                 955                 960 


Val Gln Thr Leu Asp Ser Arg Pro Ser Val Pro Ser Pro Lys Ser Ala 
                965                 970                 975     


Gly Ala Ser Gly Ser Lys Asp Ala Pro Val Pro Gly Gly Pro Gly Pro 
            980                 985                 990         


Val Leu Ser Asp Arg Arg Leu Cys  Leu Ala Leu Asp Glu  Pro Gln Leu 
        995                 1000                 1005             


Cys Asn  Gly His Met Gly Gly  Ala Ser Arg Arg Val  Glu Ser Gly 
    1010                 1015                 1020             


Ala Trp  Ala Tyr Leu Ser Pro  Leu Val Leu Arg Lys  Glu Leu Glu 
    1025                 1030                 1035             


Ser Leu  Val Glu Asn Glu Gly  Ser Glu Val Leu Ala  Leu Pro Glu 
    1040                 1045                 1050             


Leu Pro  Ser Ala His Pro Ile  Ile Phe Trp Asn Leu  Leu Trp Tyr 
    1055                 1060                 1065             


Phe Gln  Arg Leu Arg Leu Pro  Ser Ile Leu Pro Gly  Leu Val Leu 
    1070                 1075                 1080             


Ala Ser  Cys Asp Gly Pro Ser  His Ser Gln Ala Pro  Ser Pro Trp 
    1085                 1090                 1095             


Leu Thr  Pro Asp Pro Ala Ser  Val Gln Ala Arg Ser  Pro Ser Gly 
    1100                 1105                 1110             


Trp Tyr  Gly Gln Ala Leu Tyr  Leu His Pro Leu Val  Trp His Cys 
    1115                 1120                 1125             


Trp Ser  Gln Cys Cys Ala Met  Leu Asp Ser Met Lys  Cys Thr Arg 
    1130                 1135                 1140             


Leu Trp  Gly Ser Cys Trp Lys  Leu 
    1145                 1150     

<210>  756
<211>  3939
<212>  DNA
<213>  Homo sapiens

<400>  756
atggcggagg agcggccccc ccggctggtg gattacttcg tggtagctgg gcttgcaggg     60

aacggagcac ccatccctga ggaaacgtgg gttcctgaac ccagtgggcc cctgcgccct    120

ccccggccag ctgagcccat cacagatgtg gcagtcatcg ctagggcact gggcgaggaa    180

gtgccccagg gctacacatg catccaggct tctgctgggg gccacccctt ggaactcagt    240

gctggacttc tgggtggaac tcaacccgtc atctgctacc gcaggggccg tgacaagccc    300

cccctcgttg agctgggggt gttgtatgag gggaaggaac gtcccaagcc tggcttccaa    360

gtgcttgaca cgacacccta cagccactca gcaaacctgg cccctccagg ccccgggcac    420

ccccgcacct acctcactta ccggcgggca gcagaggggg cagggctgca tgccctgggc    480

atcactgacc tctgcctggt gctgcccagt aagggcgagg gcactcctca tacttactgc    540

cggctgcccc gcaacctcaa ccctggcatg tggggcccag cagtgtacct gtgctataag    600

gtgggcctgg cgaaggccaa cacgctggtg tacgaggcag gtgagtggcc cctttatccc    660

tccaatcctg tgaccctaca tccctttgcc ctggtgcctc ttggcaggca ccttaagtgt    720

ccccagagtt tactttctct ttgctactcg ggccttctct gggatccctt ggttcatttc    780

ccttggagtc tgatggaccc tgctcctttt gggtaccccc aactatgctg ggggtgcaga    840

gctgctgggc cgctacccgg aggaggacaa tgaggcgttc ccgctgcccg agtcagtgcc    900

cgtcttctgc ctgcccatgg gggccactat cgagtgctgg cctgcccaga ccaagtaccc    960

cgtgcccgtc ttctccacct ttgtgctcac gggtgcagct ggtgataagg tgtatggtgc   1020

cgccctgcag ttctacgagg cgttcccaag ggccaggcta tcagagcgac aggcacgggc   1080

actgggcctg ctgagcgccg tggagcgggg tcgggcactg gggggcagag ctgtgcgcag   1140

ccggcgtgcc atcgctgtgc tgtcccgctg gcctgccttc cctgccttcc gcgccttcct   1200

caccttcctt taccgctact ccgtctcagg cccccaccgc ctacccttgg aagcgcacat   1260

ctcccacttc attcacaacg ttcccttccc ttccccacag agaccccgca tcctagtgca   1320

gatgtctccc tatgacaact tgctcctctg tcagcctgta tcctcacccc tgcccctcag   1380

tggtgccagc ttcctgcagc tgctgcagag cctgggccct gagctggcta tcacactgct   1440

gctggctgtg ctcacagagc acaagctgct agtccactcg ctgcggccag acctgctcac   1500

cagcgtctgt gaggccctcg tctcgatgat cttcccactg cactggcagt gcccctacat   1560

tcctctgtgc ccgctggtgc tggcagatgt gctgagtgcc ccagtgccct tcattgtggg   1620

tatccactcc agctactttg atctgcatga cccgcctgct gatgtcatct gtgtagacct   1680

tgataccaac acgctcttcc agactgagga aaagaagctc ctctcccctc ggaccctgcc   1740

ccgcagaccc tacaaggttc tgctggccac actgacaaac ctgtaccagc agctggacca   1800

gacatacact ggacctgagg aggaagcatc cctggagttc ctactgacag actacgaggc   1860

agtgtgtggc cgcagggccc ggctggagcg cgaagtccaa ggagccttcc tccgcttcat   1920

ggcctgtctg ctcaagggct accgggtctt cctgcgccca ctcacccagg ccccctccga   1980

gggagctcgt gatgttgaca accttttctt cctgcagggc ttcctcaaat cccgggaacg   2040

ctccagccac aaactttact ctcagctgct gcacacacag atgttctcac agttcattga   2100

ggagtgctct tttggctctg ctcgccatgc tgcccttgaa ttctttgact cttgtgttga   2160

aaaggtccac ccagagcagg agaagcctga gccgacaccc ttagtggagc tagaggagct   2220

gtcaggaagt gagctcactg tctttatcac acctcccgag gagcctgcct taccagaggg   2280

cagtgaatcc actccccagt actgctatga tggattccca gagctacggg ctgagttgtt   2340

tgagtctctt caagagcaac ctggggccct gcctgtgcca ggcccttccc gtagcgcccc   2400

cagcagtcct gctcctcgcc gtaccaaaca ggagatgaaa gttgcacagc ggatggcaca   2460

gaagtcagca gctgtgcctg agctgtgggc ccggtgcctg ctggggcact gctatgggct   2520

gtggttcctg tgtctgcctg cctatgtgcg gtcggcaccc tcccgagtgc aggcactgca   2580

cacagcctac catgtgctgc gccagatgga gagcggcaag gtggtgctcc ctgatgaggt   2640

gtgttaccgg gtactgatgc agctctgctc acactatggg cagcctgtgc tgtctgtgcg   2700

ggtcatgctg gagatgcgtc aggcaggcat tgtgcccaac accatcacct atggctacta   2760

caataaggct gtgttggaaa gcaagtggcc gtctggcaca ccaggtgggc gtctgcgctg   2820

ggccaagctc cggaatgttg tcctgggggc tgctcagttc cgccagccct tgagagaacg   2880

gcaacagcag cagcagcagc aacagcagca gcagcagcag cagcagcagg agcaggtgtc   2940

agcacatcaa gaggcaggca gctcccaggc agagccctat ttggagcgcc cttcccctac   3000

tcgccctctt cagcgccaga ctacttgggc tgggcgaagt ctgagagacc cagcctcacc   3060

ccctggacgc ctggtgaaga gtggtagcct gggcagtgcc cgaggggcac agcccactgt   3120

ggaggccggt gtggcccaca tgatagaggc cttgggggtc ctggaacccc ggggatcacc   3180

tgtgccctgg cacgatggaa gtctctcaga cctgagcctg acaggggagg agccgctccc   3240

tggaggcagc ccagggggct caggctcagc cctgagtgcc cagtccactg aggccctgga   3300

agggctaagt gggcggggac ccaaggctgg tgggcgacag gatgaggcag gcaccccccg   3360

acgagggctg ggtgcccgcc tccaacagct gctcactcct tcccgccact cccctgcctc   3420

ccgcattccc ccacctgagc tgcctcctga cctgccaccc ccagcccgcc gcagccccat   3480

ggacagtctt ctgcaccccc gggagcgccc tggatccact gcctccgaga gctcagcctc   3540

tctgggcagt gagtgggacc tctcagaatc ttctctcagc aacctgagtc ttcgccgttc   3600

ctcagagcgc ctcagtgaca cccctggatc cttccagtca ccttccctgg aaattctgct   3660

gtccagctgc tccctgtgcc gtgcctgtga ttcgctggtg tatgatgagg aaatccatgg   3720

tccggtggtt tgtagttcct tcaaagtcag gcactgggag ctagaggagt ctcaagctcc   3780

ccttaggaag aactggtgcc ccctccagtc ctaatttttc ttgcctgccc cgccttgggg   3840

aatgcctcac ccacccaggt cctgacctgt gcaataagga ttgttccctg cgaagttttg   3900

ttggatgtaa atatagtaaa agctgcttct gtctttttc                          3939


<210>  757
<211>  965
<212>  PRT
<213>  Homo sapiens

<400>  757


Met Gly Ala Thr Ile Glu Cys Trp Pro Ala Gln Thr Lys Tyr Pro Val 
1               5                   10                  15      


Pro Val Phe Ser Thr Phe Val Leu Thr Gly Ala Ala Gly Asp Lys Val 
            20                  25                  30          


Tyr Gly Ala Ala Leu Gln Phe Tyr Glu Ala Phe Pro Arg Ala Arg Leu 
        35                  40                  45              


Ser Glu Arg Gln Ala Arg Ala Leu Gly Leu Leu Ser Ala Val Glu Arg 
    50                  55                  60                  


Gly Arg Ala Leu Gly Gly Arg Ala Val Arg Ser Arg Arg Ala Ile Ala 
65                  70                  75                  80  


Val Leu Ser Arg Trp Pro Ala Phe Pro Ala Phe Arg Ala Phe Leu Thr 
                85                  90                  95      


Phe Leu Tyr Arg Tyr Ser Val Ser Gly Pro His Arg Leu Pro Leu Glu 
            100                 105                 110         


Ala His Ile Ser His Phe Ile His Asn Val Pro Phe Pro Ser Pro Gln 
        115                 120                 125             


Arg Pro Arg Ile Leu Val Gln Met Ser Pro Tyr Asp Asn Leu Leu Leu 
    130                 135                 140                 


Cys Gln Pro Val Ser Ser Pro Leu Pro Leu Ser Gly Ala Ser Phe Leu 
145                 150                 155                 160 


Gln Leu Leu Gln Ser Leu Gly Pro Glu Leu Ala Ile Thr Leu Leu Leu 
                165                 170                 175     


Ala Val Leu Thr Glu His Lys Leu Leu Val His Ser Leu Arg Pro Asp 
            180                 185                 190         


Leu Leu Thr Ser Val Cys Glu Ala Leu Val Ser Met Ile Phe Pro Leu 
        195                 200                 205             


His Trp Gln Cys Pro Tyr Ile Pro Leu Cys Pro Leu Val Leu Ala Asp 
    210                 215                 220                 


Val Leu Ser Ala Pro Val Pro Phe Ile Val Gly Ile His Ser Ser Tyr 
225                 230                 235                 240 


Phe Asp Leu His Asp Pro Pro Ala Asp Val Ile Cys Val Asp Leu Asp 
                245                 250                 255     


Thr Asn Thr Leu Phe Gln Thr Glu Glu Lys Lys Leu Leu Ser Pro Arg 
            260                 265                 270         


Thr Leu Pro Arg Arg Pro Tyr Lys Val Leu Leu Ala Thr Leu Thr Asn 
        275                 280                 285             


Leu Tyr Gln Gln Leu Asp Gln Thr Tyr Thr Gly Pro Glu Glu Glu Ala 
    290                 295                 300                 


Ser Leu Glu Phe Leu Leu Thr Asp Tyr Glu Ala Val Cys Gly Arg Arg 
305                 310                 315                 320 


Ala Arg Leu Glu Arg Glu Val Gln Gly Ala Phe Leu Arg Phe Met Ala 
                325                 330                 335     


Cys Leu Leu Lys Gly Tyr Arg Val Phe Leu Arg Pro Leu Thr Gln Ala 
            340                 345                 350         


Pro Ser Glu Gly Ala Arg Asp Val Asp Asn Leu Phe Phe Leu Gln Gly 
        355                 360                 365             


Phe Leu Lys Ser Arg Glu Arg Ser Ser His Lys Leu Tyr Ser Gln Leu 
    370                 375                 380                 


Leu His Thr Gln Met Phe Ser Gln Phe Ile Glu Glu Cys Ser Phe Gly 
385                 390                 395                 400 


Ser Ala Arg His Ala Ala Leu Glu Phe Phe Asp Ser Cys Val Glu Lys 
                405                 410                 415     


Val His Pro Glu Gln Glu Lys Pro Glu Pro Thr Pro Leu Val Glu Leu 
            420                 425                 430         


Glu Glu Leu Ser Gly Ser Glu Leu Thr Val Phe Ile Thr Pro Pro Glu 
        435                 440                 445             


Glu Pro Ala Leu Pro Glu Gly Ser Glu Ser Thr Pro Gln Tyr Cys Tyr 
    450                 455                 460                 


Asp Gly Phe Pro Glu Leu Arg Ala Glu Leu Phe Glu Ser Leu Gln Glu 
465                 470                 475                 480 


Gln Pro Gly Ala Leu Pro Val Pro Gly Pro Ser Arg Ser Ala Pro Ser 
                485                 490                 495     


Ser Pro Ala Pro Arg Arg Thr Lys Gln Glu Met Lys Val Ala Gln Arg 
            500                 505                 510         


Met Ala Gln Lys Ser Ala Ala Val Pro Glu Leu Trp Ala Arg Cys Leu 
        515                 520                 525             


Leu Gly His Cys Tyr Gly Leu Trp Phe Leu Cys Leu Pro Ala Tyr Val 
    530                 535                 540                 


Arg Ser Ala Pro Ser Arg Val Gln Ala Leu His Thr Ala Tyr His Val 
545                 550                 555                 560 


Leu Arg Gln Met Glu Ser Gly Lys Val Val Leu Pro Asp Glu Val Cys 
                565                 570                 575     


Tyr Arg Val Leu Met Gln Leu Cys Ser His Tyr Gly Gln Pro Val Leu 
            580                 585                 590         


Ser Val Arg Val Met Leu Glu Met Arg Gln Ala Gly Ile Val Pro Asn 
        595                 600                 605             


Thr Ile Thr Tyr Gly Tyr Tyr Asn Lys Ala Val Leu Glu Ser Lys Trp 
    610                 615                 620                 


Pro Ser Gly Thr Pro Gly Gly Arg Leu Arg Trp Ala Lys Leu Arg Asn 
625                 630                 635                 640 


Val Val Leu Gly Ala Ala Gln Phe Arg Gln Pro Leu Arg Glu Arg Gln 
                645                 650                 655     


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Glu 
            660                 665                 670         


Gln Val Ser Ala His Gln Glu Ala Gly Ser Ser Gln Ala Glu Pro Tyr 
        675                 680                 685             


Leu Glu Arg Pro Ser Pro Thr Arg Pro Leu Gln Arg Gln Thr Thr Trp 
    690                 695                 700                 


Ala Gly Arg Ser Leu Arg Asp Pro Ala Ser Pro Pro Gly Arg Leu Val 
705                 710                 715                 720 


Lys Ser Gly Ser Leu Gly Ser Ala Arg Gly Ala Gln Pro Thr Val Glu 
                725                 730                 735     


Ala Gly Val Ala His Met Ile Glu Ala Leu Gly Val Leu Glu Pro Arg 
            740                 745                 750         


Gly Ser Pro Val Pro Trp His Asp Gly Ser Leu Ser Asp Leu Ser Leu 
        755                 760                 765             


Thr Gly Glu Glu Pro Leu Pro Gly Gly Ser Pro Gly Gly Ser Gly Ser 
    770                 775                 780                 


Ala Leu Ser Ala Gln Ser Thr Glu Ala Leu Glu Gly Leu Ser Gly Arg 
785                 790                 795                 800 


Gly Pro Lys Ala Gly Gly Arg Gln Asp Glu Ala Gly Thr Pro Arg Arg 
                805                 810                 815     


Gly Leu Gly Ala Arg Leu Gln Gln Leu Leu Thr Pro Ser Arg His Ser 
            820                 825                 830         


Pro Ala Ser Arg Ile Pro Pro Pro Glu Leu Pro Pro Asp Leu Pro Pro 
        835                 840                 845             


Pro Ala Arg Arg Ser Pro Met Asp Ser Leu Leu His Pro Arg Glu Arg 
    850                 855                 860                 


Pro Gly Ser Thr Ala Ser Glu Ser Ser Ala Ser Leu Gly Ser Glu Trp 
865                 870                 875                 880 


Asp Leu Ser Glu Ser Ser Leu Ser Asn Leu Ser Leu Arg Arg Ser Ser 
                885                 890                 895     


Glu Arg Leu Ser Asp Thr Pro Gly Ser Phe Gln Ser Pro Ser Leu Glu 
            900                 905                 910         


Ile Leu Leu Ser Ser Cys Ser Leu Cys Arg Ala Cys Asp Ser Leu Val 
        915                 920                 925             


Tyr Asp Glu Glu Ile His Gly Pro Val Val Cys Ser Ser Phe Lys Val 
    930                 935                 940                 


Arg His Trp Glu Leu Glu Glu Ser Gln Ala Pro Leu Arg Lys Asn Trp 
945                 950                 955                 960 


Cys Pro Leu Gln Ser 
                965 

<210>  758
<211>  5575
<212>  DNA
<213>  Homo sapiens

<400>  758
atggcggagg agcggccccc ccggctggtg gattacttcg tggtagctgg gcttgcaggg     60

aacggagcac ccatccctga ggaaacgtgg gttcctgaac ccagtgggcc cctgcgccct    120

ccccggccag ctgagcccat cacagatgtg gcagtcatcg ctagggcact gggcgaggaa    180

gtgccccagg gctacacatg catccaggct tctgctgggg gccacccctt ggaactcagt    240

gctggacttc tgggtggaac tcaacccgtc atctgctacc gcaggggccg tgacaagccc    300

cccctcgttg agctgggggt gttgtatgag gggaaggaac gtcccaagcc tggcttccaa    360

gtgcttgaca cgacacccta cagccactca gcaaacctgg cccctccagg ccccgggcac    420

ccccgcacct acctcactta ccggcgggca gcagaggggg cagggctgca tgccctgggc    480

atcactgacc tctgcctggt gctgcccagt aagggcgagg gcactcctca tacttactgc    540

cggctgcccc gcaacctcaa ccctggcatg tggggcccag cagtgtacct gtgctataag    600

gtgggcctgg cgaaggccaa cacgctggtg tacgaggcag gtgagtggcc cctttatccc    660

tccaatcctg tgaccctaca tccctttgcc ctggtgcctc ttggcaggca ccttaagtgt    720

ccccagagtt tactttctct ttgctactcg ggccttctct gggatccctt ggttcatttc    780

ccttggagtc tgatggaccc tgctcctttt gggtaccccc aactatgctg ggggtgcaga    840

gctgctgggc cgctacccgg aggaggacaa tgaggcgttc ccgctgcccg agtcagtgcc    900

cgtcttctgc ctgcccatgg gggccactat cgagtgctgg cctgcccaga ccaagtaccc    960

cgtgcccgtc ttctccacct ttgtgctcac gggtgcagct ggtgataagg tgtatggtgc   1020

cgccctgcag ttctacgagg cgttcccaag ggccaggcta tcagagcgac aggcacgggc   1080

actgggcctg ctgagcgccg tggagcgggg tcgggcactg gggggcagag ctgtgcgcag   1140

ccggcgtgcc atcgctgtgc tgtcccgctg gcctgccttc cctgccttcc gcgccttcct   1200

caccttcctt taccgctact ccgtctcagg cccccaccgc ctacccttgg aagcgcacat   1260

ctcccacttc attcacaacg ttcccttccc ttccccacag agaccccgca tcctagtgca   1320

gatgtctccc tatgacaact tgctcctctg tcagcctgta tcctcacccc tgcccctcag   1380

tggtgccagc ttcctgcagc tgctgcagag cctgggccct gagctggcta tcacactgct   1440

gctggctgtg ctcacagagc acaagctgct agtccactcg ctgcggccag acctgctcac   1500

cagcgtctgt gaggccctcg tctcgatgat cttcccactg cactggcagt gcccctacat   1560

tcctctgtgc ccgctggtgc tggcagatgt gctgagtgcc ccagtgccct tcattgtggg   1620

tatccactcc agctactttg atctgcatga cccgcctgct gatgtcatct gtgtagacct   1680

tgataccaac acgctcttcc agactgagga aaagaagctc ctctcccctc ggaccctgcc   1740

ccgcagaccc tacaaggttc tgctggccac actgacaaac ctgtaccagc agctggacca   1800

gacatacact ggacctgagg aggaagcatc cctggagttc ctactgacag actacgaggc   1860

agtgtgtggc cgcagggccc ggctggagcg cgaagtccaa ggagccttcc tccgcttcat   1920

ggcctgtctg ctcaagggct accgggtctt cctgcgccca ctcacccagg ccccctccga   1980

gggagctcgt gatgttgaca accttttctt cctgcagggc ttcctcaaat cccgggaacg   2040

ctccagccac aaactttact ctcagctgct gcacacacag atgttctcac agttcattga   2100

ggagtgctct tttggctctg ctcgccatgc tgcccttgaa ttctttgact cttgtgttga   2160

aaaggtccac ccagagcagg agaagcctga gccgacaccc ttagtggagc tagaggagct   2220

gtcaggaagt gagctcactg tctttatcac acctcccgag gagcctgcct taccagaggg   2280

cagtgaatcc actccccagt actgctatga tggattccca gagctacggg ctgagttgtt   2340

tgagtctctt caagagcaac ctggggccct gcctgtgcca ggcccttccc gtagcgcccc   2400

cagcagtcct gctcctcgcc gtaccaaaca ggagatgaaa gttgcacagc ggatggcaca   2460

gaagtcagca gctgtgcctg agctgtgggc ccggtgcctg ctggggcact gctatgggct   2520

gtggttcctg tgtctgcctg cctatgtgcg gtcggcaccc tcccgagtgc aggcactgca   2580

cacagcctac catgtgctgc gccagatgga gagcggcaag gtggtgctcc ctgatgaggt   2640

gtgttaccgg gtactgatgc agctctgctc acactatggg cagcctgtgc tgtctgtgcg   2700

ggtcatgctg gagatgcgtc aggcaggcat tgtgcccaac accatcacct atggctacta   2760

caataaggct gtgttggaaa gcaagtggcc gtctggcaca ccaggtgggc gtctgcgctg   2820

ggccaagctc cggaatgttg tcctgggggc tgctcagttc cgccagccct tgagagaacg   2880

gcaacagcag cagcagcagc aacagcagca gcagcagcag cagcagcagg agcaggtgtc   2940

agcacatcaa gaggcaggca gctcccaggc agagccctat ttggagcgcc cttcccctac   3000

tcgccctctt cagcgccaga ctacttgggc tgggcgaagt ctgagagacc cagcctcacc   3060

ccctggacgc ctggtgaaga gtggtagcct gggcagtgcc cgaggggcac agcccactgt   3120

ggaggccggt gtggcccaca tgatagaggc cttgggggtc ctggaacccc ggggatcacc   3180

tgtgccctgg cacgatggaa gtctctcaga cctgagcctg acaggggagg agccgctccc   3240

tggaggcagc ccagggggct caggctcagc cctgagtgcc cagtccactg aggccctgga   3300

agggctaagt gggcggggac ccaaggctgg tgggcgacag gatgaggcag gcaccccccg   3360

acgagggctg ggtgcccgcc tccaacagct gctcactcct tcccgccact cccctgcctc   3420

ccgcattccc ccacctgagc tgcctcctga cctgccaccc ccagcccgcc gcagccccat   3480

ggacagtctt ctgcaccccc gggagcgccc tggatccact gcctccgaga gctcagcctc   3540

tctgggcagt gagtgggacc tctcagaatc ttctctcagc aacctgagtc ttcgccgttc   3600

ctcagagcgc ctcagtgaca cccctggatc cttccagtca ccttccctgg aaattctgct   3660

gtccagctgc tccctgtgcc gtgcctgtga ttcgctggtg tatgatgagg aaatcatggc   3720

tggctgggca cctgatgact ctaacctcaa cacaacctgc cccttctgcg cctgcccctt   3780

tgtgcccctg ctcagtgtcc agacccttga ttcccggccc agtgtcccca gccccaaatc   3840

tgctggtgcc agtggcagca aagatgctcc tgtccctggt ggtcctggcc ctgtgctcag   3900

tgaccgaagg ctctgccttg ctctggatga gccccagctc tgcaacgggc acatgggggg   3960

agcctcccgg cgggttgaga gtggggcatg ggcatacctg agccccctgg tgctgcgtaa   4020

ggagctggag tcgctggtag agaacgaggg cagtgaggtg ctggcgttgc ctgaactgcc   4080

ctctgcccac cccatcatct tctggaacct tttgtggtat ttccaacggc tacgcctgcc   4140

cagtattcta ccaggcctgg tgctggcctc ctgtgatggg ccttcgcact cccaggcccc   4200

atctccttgg ctaacccctg atccagcctc tgttcaggta cggctgctgt gggatgtact   4260

gacccctgac cccaatagct gcccacctct ctatgtgctc tggagggtcc acagtgagtc   4320

tggtatttgg cctgggtggg gagggtgggt cccataccca gagggctcag tgattctggt   4380

ggccttcttt cctttcatcc aggccagatc ccccagcggg tggtatggcc aggccctgta   4440

cctgcatccc ttagtttggc actgttggag tcagtgctgc gccatgttgg actcaatgaa   4500

gtgcacaagg ctgtggggct cctgctggaa actctagggc ccccacccac tggcctgcac   4560

ctgcagaggg gaatctaccg tgagatatta ttcctgacaa tggctgctct gggcaaggac   4620

cacgtggaca tagtggcctt cgataagaag tacaagtctg cctttaacaa gctggccagc   4680

agcatgggca aggaggagct gaggcaccgg cgggcgcaga tgcccactcc caaggccatt   4740

gactgccgaa aatgttttgg agcacctcca gaatgctaga gaccttaagc ttccctctcc   4800

agcctagggt ggggaagtga ggaagaaggg attctagagt taaactgctt ccctgttgcc   4860

ttcatggagt tgggaacagg ctgggaagga tgcccagtca aaggctccaa gcgaggacaa   4920

caggaagagg gatccactgt taccaaaagt cctgattccc ccatcaccaa cctacccagt   4980

ttgttcgtgc tgatgttggg ggagatctgg ggggagttgg tacagctctg ttcttccctt   5040

gtcctatacc gggaactccc ctccagggta cccacagatc tgcattgccc tggtcatttt   5100

agaagttttt gttttaaaaa acaactggaa agatgcagag ctactgagcc tttgccctga   5160

atgggaggta gggatgtcat tctccaccaa taatggtccc tcttccctga cgttgctgaa   5220

ggagcccaag gctctccatg cctttctacc taagtgtttg tattttattt taaattattt   5280

attctggagc cacagccccc ttgcttatga ggttcttatg gagagtgaga aagggaaggg   5340

aaatagggca ccatggtccg gtggtttgta gttccttcaa agtcaggcac tgggagctag   5400

aggagtctca agctcccctt aggaagaact ggtgccccct ccagtcctaa tttttcttgc   5460

ctgccccgcc ttggggaatg cctcacccac ccaggtcctg acctgtgcaa taaggattgt   5520

tccctgcgaa gttttgttgg atgtaaatat agtaaaagct gcttctgtct ttttc        5575


<210>  759
<211>  1206
<212>  PRT
<213>  Homo sapiens

<400>  759


Met Gly Ala Thr Ile Glu Cys Trp Pro Ala Gln Thr Lys Tyr Pro Val 
1               5                   10                  15      


Pro Val Phe Ser Thr Phe Val Leu Thr Gly Ala Ala Gly Asp Lys Val 
            20                  25                  30          


Tyr Gly Ala Ala Leu Gln Phe Tyr Glu Ala Phe Pro Arg Ala Arg Leu 
        35                  40                  45              


Ser Glu Arg Gln Ala Arg Ala Leu Gly Leu Leu Ser Ala Val Glu Arg 
    50                  55                  60                  


Gly Arg Ala Leu Gly Gly Arg Ala Val Arg Ser Arg Arg Ala Ile Ala 
65                  70                  75                  80  


Val Leu Ser Arg Trp Pro Ala Phe Pro Ala Phe Arg Ala Phe Leu Thr 
                85                  90                  95      


Phe Leu Tyr Arg Tyr Ser Val Ser Gly Pro His Arg Leu Pro Leu Glu 
            100                 105                 110         


Ala His Ile Ser His Phe Ile His Asn Val Pro Phe Pro Ser Pro Gln 
        115                 120                 125             


Arg Pro Arg Ile Leu Val Gln Met Ser Pro Tyr Asp Asn Leu Leu Leu 
    130                 135                 140                 


Cys Gln Pro Val Ser Ser Pro Leu Pro Leu Ser Gly Ala Ser Phe Leu 
145                 150                 155                 160 


Gln Leu Leu Gln Ser Leu Gly Pro Glu Leu Ala Ile Thr Leu Leu Leu 
                165                 170                 175     


Ala Val Leu Thr Glu His Lys Leu Leu Val His Ser Leu Arg Pro Asp 
            180                 185                 190         


Leu Leu Thr Ser Val Cys Glu Ala Leu Val Ser Met Ile Phe Pro Leu 
        195                 200                 205             


His Trp Gln Cys Pro Tyr Ile Pro Leu Cys Pro Leu Val Leu Ala Asp 
    210                 215                 220                 


Val Leu Ser Ala Pro Val Pro Phe Ile Val Gly Ile His Ser Ser Tyr 
225                 230                 235                 240 


Phe Asp Leu His Asp Pro Pro Ala Asp Val Ile Cys Val Asp Leu Asp 
                245                 250                 255     


Thr Asn Thr Leu Phe Gln Thr Glu Glu Lys Lys Leu Leu Ser Pro Arg 
            260                 265                 270         


Thr Leu Pro Arg Arg Pro Tyr Lys Val Leu Leu Ala Thr Leu Thr Asn 
        275                 280                 285             


Leu Tyr Gln Gln Leu Asp Gln Thr Tyr Thr Gly Pro Glu Glu Glu Ala 
    290                 295                 300                 


Ser Leu Glu Phe Leu Leu Thr Asp Tyr Glu Ala Val Cys Gly Arg Arg 
305                 310                 315                 320 


Ala Arg Leu Glu Arg Glu Val Gln Gly Ala Phe Leu Arg Phe Met Ala 
                325                 330                 335     


Cys Leu Leu Lys Gly Tyr Arg Val Phe Leu Arg Pro Leu Thr Gln Ala 
            340                 345                 350         


Pro Ser Glu Gly Ala Arg Asp Val Asp Asn Leu Phe Phe Leu Gln Gly 
        355                 360                 365             


Phe Leu Lys Ser Arg Glu Arg Ser Ser His Lys Leu Tyr Ser Gln Leu 
    370                 375                 380                 


Leu His Thr Gln Met Phe Ser Gln Phe Ile Glu Glu Cys Ser Phe Gly 
385                 390                 395                 400 


Ser Ala Arg His Ala Ala Leu Glu Phe Phe Asp Ser Cys Val Glu Lys 
                405                 410                 415     


Val His Pro Glu Gln Glu Lys Pro Glu Pro Thr Pro Leu Val Glu Leu 
            420                 425                 430         


Glu Glu Leu Ser Gly Ser Glu Leu Thr Val Phe Ile Thr Pro Pro Glu 
        435                 440                 445             


Glu Pro Ala Leu Pro Glu Gly Ser Glu Ser Thr Pro Gln Tyr Cys Tyr 
    450                 455                 460                 


Asp Gly Phe Pro Glu Leu Arg Ala Glu Leu Phe Glu Ser Leu Gln Glu 
465                 470                 475                 480 


Gln Pro Gly Ala Leu Pro Val Pro Gly Pro Ser Arg Ser Ala Pro Ser 
                485                 490                 495     


Ser Pro Ala Pro Arg Arg Thr Lys Gln Glu Met Lys Val Ala Gln Arg 
            500                 505                 510         


Met Ala Gln Lys Ser Ala Ala Val Pro Glu Leu Trp Ala Arg Cys Leu 
        515                 520                 525             


Leu Gly His Cys Tyr Gly Leu Trp Phe Leu Cys Leu Pro Ala Tyr Val 
    530                 535                 540                 


Arg Ser Ala Pro Ser Arg Val Gln Ala Leu His Thr Ala Tyr His Val 
545                 550                 555                 560 


Leu Arg Gln Met Glu Ser Gly Lys Val Val Leu Pro Asp Glu Val Cys 
                565                 570                 575     


Tyr Arg Val Leu Met Gln Leu Cys Ser His Tyr Gly Gln Pro Val Leu 
            580                 585                 590         


Ser Val Arg Val Met Leu Glu Met Arg Gln Ala Gly Ile Val Pro Asn 
        595                 600                 605             


Thr Ile Thr Tyr Gly Tyr Tyr Asn Lys Ala Val Leu Glu Ser Lys Trp 
    610                 615                 620                 


Pro Ser Gly Thr Pro Gly Gly Arg Leu Arg Trp Ala Lys Leu Arg Asn 
625                 630                 635                 640 


Val Val Leu Gly Ala Ala Gln Phe Arg Gln Pro Leu Arg Glu Arg Gln 
                645                 650                 655     


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Glu 
            660                 665                 670         


Gln Val Ser Ala His Gln Glu Ala Gly Ser Ser Gln Ala Glu Pro Tyr 
        675                 680                 685             


Leu Glu Arg Pro Ser Pro Thr Arg Pro Leu Gln Arg Gln Thr Thr Trp 
    690                 695                 700                 


Ala Gly Arg Ser Leu Arg Asp Pro Ala Ser Pro Pro Gly Arg Leu Val 
705                 710                 715                 720 


Lys Ser Gly Ser Leu Gly Ser Ala Arg Gly Ala Gln Pro Thr Val Glu 
                725                 730                 735     


Ala Gly Val Ala His Met Ile Glu Ala Leu Gly Val Leu Glu Pro Arg 
            740                 745                 750         


Gly Ser Pro Val Pro Trp His Asp Gly Ser Leu Ser Asp Leu Ser Leu 
        755                 760                 765             


Thr Gly Glu Glu Pro Leu Pro Gly Gly Ser Pro Gly Gly Ser Gly Ser 
    770                 775                 780                 


Ala Leu Ser Ala Gln Ser Thr Glu Ala Leu Glu Gly Leu Ser Gly Arg 
785                 790                 795                 800 


Gly Pro Lys Ala Gly Gly Arg Gln Asp Glu Ala Gly Thr Pro Arg Arg 
                805                 810                 815     


Gly Leu Gly Ala Arg Leu Gln Gln Leu Leu Thr Pro Ser Arg His Ser 
            820                 825                 830         


Pro Ala Ser Arg Ile Pro Pro Pro Glu Leu Pro Pro Asp Leu Pro Pro 
        835                 840                 845             


Pro Ala Arg Arg Ser Pro Met Asp Ser Leu Leu His Pro Arg Glu Arg 
    850                 855                 860                 


Pro Gly Ser Thr Ala Ser Glu Ser Ser Ala Ser Leu Gly Ser Glu Trp 
865                 870                 875                 880 


Asp Leu Ser Glu Ser Ser Leu Ser Asn Leu Ser Leu Arg Arg Ser Ser 
                885                 890                 895     


Glu Arg Leu Ser Asp Thr Pro Gly Ser Phe Gln Ser Pro Ser Leu Glu 
            900                 905                 910         


Ile Leu Leu Ser Ser Cys Ser Leu Cys Arg Ala Cys Asp Ser Leu Val 
        915                 920                 925             


Tyr Asp Glu Glu Ile Met Ala Gly Trp Ala Pro Asp Asp Ser Asn Leu 
    930                 935                 940                 


Asn Thr Thr Cys Pro Phe Cys Ala Cys Pro Phe Val Pro Leu Leu Ser 
945                 950                 955                 960 


Val Gln Thr Leu Asp Ser Arg Pro Ser Val Pro Ser Pro Lys Ser Ala 
                965                 970                 975     


Gly Ala Ser Gly Ser Lys Asp Ala Pro Val Pro Gly Gly Pro Gly Pro 
            980                 985                 990         


Val Leu Ser Asp Arg Arg Leu Cys  Leu Ala Leu Asp Glu  Pro Gln Leu 
        995                 1000                 1005             


Cys Asn  Gly His Met Gly Gly  Ala Ser Arg Arg Val  Glu Ser Gly 
    1010                 1015                 1020             


Ala Trp  Ala Tyr Leu Ser Pro  Leu Val Leu Arg Lys  Glu Leu Glu 
    1025                 1030                 1035             


Ser Leu  Val Glu Asn Glu Gly  Ser Glu Val Leu Ala  Leu Pro Glu 
    1040                 1045                 1050             


Leu Pro  Ser Ala His Pro Ile  Ile Phe Trp Asn Leu  Leu Trp Tyr 
    1055                 1060                 1065             


Phe Gln  Arg Leu Arg Leu Pro  Ser Ile Leu Pro Gly  Leu Val Leu 
    1070                 1075                 1080             


Ala Ser  Cys Asp Gly Pro Ser  His Ser Gln Ala Pro  Ser Pro Trp 
    1085                 1090                 1095             


Leu Thr  Pro Asp Pro Ala Ser  Val Gln Val Arg Leu  Leu Trp Asp 
    1100                 1105                 1110             


Val Leu  Thr Pro Asp Pro Asn  Ser Cys Pro Pro Leu  Tyr Val Leu 
    1115                 1120                 1125             


Trp Arg  Val His Ser Glu Ser  Gly Ile Trp Pro Gly  Trp Gly Gly 
    1130                 1135                 1140             


Trp Val  Pro Tyr Pro Glu Gly  Ser Val Ile Leu Val  Ala Phe Phe 
    1145                 1150                 1155             


Pro Phe  Ile Gln Ala Arg Ser  Pro Ser Gly Trp Tyr  Gly Gln Ala 
    1160                 1165                 1170             


Leu Tyr  Leu His Pro Leu Val  Trp His Cys Trp Ser  Gln Cys Cys 
    1175                 1180                 1185             


Ala Met  Leu Asp Ser Met Lys  Cys Thr Arg Leu Trp  Gly Ser Cys 
    1190                 1195                 1200             


Trp Lys  Leu 
    1205     

<210>  760
<211>  5486
<212>  DNA
<213>  Homo sapiens

<400>  760
atggcggagg agcggccccc ccggctggtg gattacttcg tggtagctgg gcttgcaggg     60

aacggagcac ccatccctga ggaaacgtgg gttcctgaac ccagtgggcc cctgcgccct    120

ccccggccag ctgagcccat cacagatgtg gcagtcatcg ctagggcact gggcgaggaa    180

gtgccccagg gctacacatg catccaggct tctgctgggg gccacccctt ggaactcagt    240

gctggacttc tgggtggaac tcaacccgtc atctgctacc gcaggggccg tgacaagccc    300

cccctcgttg agctgggggt gttgtatgag gggaaggaac gtcccaagcc tggcttccaa    360

gtgcttgaca cgacacccta cagccactca gcaaacctgg cccctccagg ccccgggcac    420

ccccgcacct acctcactta ccggcgggca gcagaggggg cagggctgca tgccctgggc    480

atcactgacc tctgcctggt gctgcccagt aagggcgagg gcactcctca tacttactgc    540

cggctgcccc gcaacctcaa ccctggcatg tggggcccag cagtgtacct gtgctataag    600

gtgggcctgg cgaaggccaa cacgctggtg tacgaggcag gtgagtggcc cctttatccc    660

tccaatcctg tgaccctaca tccctttgcc ctggtgcctc ttggcaggca ccttaagtgt    720

ccccagagtt tactttctct ttgctactcg ggccttctct gggatccctt ggttcatttc    780

ccttggagtc tgatggaccc tgctcctttt gggtaccccc aactatgctg ggggtgcaga    840

gctgctgggc cgctacccgg aggaggacaa tgaggcgttc ccgctgcccg agtcagtgcc    900

cgtcttctgc ctgcccatgg gggccactat cgagtgctgg cctgcccaga ccaagtaccc    960

cgtgcccgtc ttctccacct ttgtgctcac gggtgcagct ggtgataagg tgtatggtgc   1020

cgccctgcag ttctacgagg cgttcccaag ggccaggcta tcagagcgac aggcacgggc   1080

actgggcctg ctgagcgccg tggagcgggg tcgggcactg gggggcagag ctgtgcgcag   1140

ccggcgtgcc atcgctgtgc tgtcccgctg gcctgccttc cctgccttcc gcgccttcct   1200

caccttcctt taccgctact ccgtctcagg cccccaccgc ctacccttgg aagcgcacat   1260

ctcccacttc attcacaacg ttcccttccc ttccccacag agaccccgca tcctagtgca   1320

gatgtctccc tatgacaact tgctcctctg tcagcctgta tcctcacccc tgcccctcag   1380

tggtgccagc ttcctgcagc tgctgcagag cctgggccct gagctggcta tcacactgct   1440

gctggctgtg ctcacagagc acaagctgct agtccactcg ctgcggccag acctgctcac   1500

cagcgtctgt gaggccctcg tctcgatgat cttcccactg cactggcagt gcccctacat   1560

tcctctgtgc ccgctggtgc tggcagatgt gctgagtgcc ccagtgccct tcattgtggg   1620

tatccactcc agctactttg atctgcatga cccgcctgct gatgtcatct gtgtagacct   1680

tgataccaac acgctcttcc agactgagga aaagaagctc ctctcccctc ggaccctgcc   1740

ccgcagaccc tacaaggttc tgctggccac actgacaaac ctgtaccagc agctggacca   1800

gacatacact ggacctgagg aggaagcatc cctggagttc ctactgacag actacgaggc   1860

agtgtgtggc cgcagggccc ggctggagcg cgaagtccaa ggagccttcc tccgcttcat   1920

ggcctgtctg ctcaagggct accgggtctt cctgcgccca ctcacccagg ccccctccga   1980

gggagctcgt gatgttgaca accttttctt cctgcagggc ttcctcaaat cccgggaacg   2040

ctccagccac aaactttact ctcagctgct gcacacacag atgttctcac agttcattga   2100

ggagtgctct tttggctctg ctcgccatgc tgcccttgaa ttctttgact cttgtgttga   2160

aaaggtccac ccagagcagg agaagcctga gccgacaccc ttagtggagc tagaggagct   2220

gtcaggaagt gagctcactg tctttatcac acctcccgag gagcctgcct taccagaggg   2280

cagtgaatcc actccccagt actgctatga tggattccca gagctacggg ctgagttgtt   2340

tgagtctctt caagagcaac ctggggccct gcctgtgcca ggcccttccc gtagcgcccc   2400

cagcagtcct gctcctcgcc gtaccaaaca ggagatgaaa gttgcacagc ggatggcaca   2460

gaagtcagca gctgtgcctg agctgtgggc ccggtgcctg ctggggcact gctatgggct   2520

gtggttcctg tgtctgcctg cctatgtgcg gtcggcaccc tcccgagtgc aggcactgca   2580

cacagcctac catgtgctgc gccagatgga gagcggcaag gtggtgctcc ctgatgaggt   2640

gtgttaccgg gtactgatgc agctctgctc acactatggg cagcctgtgc tgtctgtgcg   2700

ggtcatgctg gagatgcgtc aggcaggcat tgtgcccaac accatcacct atggctacta   2760

caataaggct gtgttggaaa gcaagtggcc gtctggcaca ccaggtgggc gtctgcgctg   2820

ggccaagctc cggaatgttg tcctgggggc tgctcagttc cgccagccct tgagagaacg   2880

gcaacagcag cagcagcagc aacagcagca gcagcagcag cagcagcagg agcaggtgtc   2940

agcacatcaa gaggcaggca gctcccaggc agagccctat ttggagcgcc cttcccctac   3000

tcgccctctt cagcgccaga ctacttgggc tgggcgaagt ctgagagacc cagcctcacc   3060

ccctggacgc ctggtgaaga gtggtagcct gggcagtgcc cgaggggcac agcccactgt   3120

ggaggccggt gtggcccaca tgatagaggc cttgggggtc ctggaacccc ggggatcacc   3180

tgtgccctgg cacgatggaa gtctctcaga cctgagcctg acaggggagg agccgctccc   3240

tggaggcagc ccagggggct caggctcagc cctgagtgcc cagtccactg aggccctgga   3300

agggctaagt gggcggggac ccaaggctgg tgggcgacag gatgaggcag gcaccccccg   3360

acgagggctg ggtgcccgcc tccaacagct gctcactcct tcccgccact cccctgcctc   3420

ccgcattccc ccacctgagc tgcctcctga cctgccaccc ccagcccgcc gcagccccat   3480

ggacagtctt ctgcaccccc gggagcgccc tggatccact gcctccgaga gctcagcctc   3540

tctgggcagt gagtgggacc tctcagaatc ttctctcagc aacctgagtc ttcgccgttc   3600

ctcagagcgc ctcagtgaca cccctggatc cttccagtca ccttccctgg aaattctgct   3660

gtccagctgc tccctgtgcc gtgcctgtga ttcgctggtg tatgatgagg aaatcatggc   3720

tggctgggca cctgatgact ctaacctcaa cacaacctgc cccttctgcg cctgcccctt   3780

tgtgcccctg ctcagtgtcc agacccttga ttcccggccc agtgtcccca gccccaaatc   3840

tgctggtgcc agtggcagca aagatgctcc tgtccctggt ggtcctggcc ctgtgctcag   3900

tgaccgaagg ctctgccttg ctctggatga gccccagctc tgcaacgggc acatgggggg   3960

agcctcccgg cgggttgaga gtggggcatg ggcatacctg agccccctgg tgctgcgtaa   4020

ggagctggag tcgctggtag agaacgaggg cagtgaggtg ctggcgttgc ctgaactgcc   4080

ctctgcccac cccatcatct tctggaacct tttgtggtat ttccaacggc tacgcctgcc   4140

cagtattcta ccaggcctgg tgctggcctc ctgtgatggg ccttcgcact cccaggcccc   4200

atctccttgg ctaacccctg atccagcctc tgttcaggta cggctgctgt gggatgtact   4260

gacccctgac cccaatagct gcccacctct ctatgtgctc tggagggtcc acagccagat   4320

cccccagcgg gtggtatggc caggccctgt acctgcatcc cttagtttgg cactgttgga   4380

gtcagtgctg cgccatgttg gactcaatga agtgcacaag gctgtggggc tcctgctgga   4440

aactctaggg cccccaccca ctggcctgca cctgcagagg ggaatctacc gtgagatatt   4500

attcctgaca atggctgctc tgggcaagga ccacgtggac atagtggcct tcgataagaa   4560

gtacaagtct gcctttaaca agctggccag cagcatgggc aaggaggagc tgaggcaccg   4620

gcgggcgcag atgcccactc ccaaggccat tgactgccga aaatgttttg gagcacctcc   4680

agaatgctag agaccttaag cttccctctc cagcctaggg tggggaagtg aggaagaagg   4740

gattctagag ttaaactgct tccctgttgc cttcatggag ttgggaacag gctgggaagg   4800

atgcccagtc aaaggctcca agcgaggaca acaggaagag ggatccactg ttaccaaaag   4860

tcctgattcc cccatcacca acctacccag tttgttcgtg ctgatgttgg gggagatctg   4920

gggggagttg gtacagctct gttcttccct tgtcctatac cgggaactcc cctccagggt   4980

acccacagat ctgcattgcc ctggtcattt tagaagtttt tgttttaaaa aacaactgga   5040

aagatgcaga gctactgagc ctttgccctg aatgggaggt agggatgtca ttctccacca   5100

ataatggtcc ctcttccctg acgttgctga aggagcccaa ggctctccat gcctttctac   5160

ctaagtgttt gtattttatt ttaaattatt tattctggag ccacagcccc cttgcttatg   5220

aggttcttat ggagagtgag aaagggaagg gaaatagggc accatggtcc ggtggtttgt   5280

agttccttca aagtcaggca ctgggagcta gaggagtctc aagctcccct taggaagaac   5340

tggtgccccc tccagtccta atttttcttg cctgccccgc cttggggaat gcctcaccca   5400

cccaggtcct gacctgtgca ataaggattg ttccctgcga agttttgttg gatgtaaata   5460

tagtaaaagc tgcttctgtc tttttc                                        5486


<210>  761
<211>  1257
<212>  PRT
<213>  Homo sapiens

<400>  761


Met Gly Ala Thr Ile Glu Cys Trp Pro Ala Gln Thr Lys Tyr Pro Val 
1               5                   10                  15      


Pro Val Phe Ser Thr Phe Val Leu Thr Gly Ala Ala Gly Asp Lys Val 
            20                  25                  30          


Tyr Gly Ala Ala Leu Gln Phe Tyr Glu Ala Phe Pro Arg Ala Arg Leu 
        35                  40                  45              


Ser Glu Arg Gln Ala Arg Ala Leu Gly Leu Leu Ser Ala Val Glu Arg 
    50                  55                  60                  


Gly Arg Ala Leu Gly Gly Arg Ala Val Arg Ser Arg Arg Ala Ile Ala 
65                  70                  75                  80  


Val Leu Ser Arg Trp Pro Ala Phe Pro Ala Phe Arg Ala Phe Leu Thr 
                85                  90                  95      


Phe Leu Tyr Arg Tyr Ser Val Ser Gly Pro His Arg Leu Pro Leu Glu 
            100                 105                 110         


Ala His Ile Ser His Phe Ile His Asn Val Pro Phe Pro Ser Pro Gln 
        115                 120                 125             


Arg Pro Arg Ile Leu Val Gln Met Ser Pro Tyr Asp Asn Leu Leu Leu 
    130                 135                 140                 


Cys Gln Pro Val Ser Ser Pro Leu Pro Leu Ser Gly Ala Ser Phe Leu 
145                 150                 155                 160 


Gln Leu Leu Gln Ser Leu Gly Pro Glu Leu Ala Ile Thr Leu Leu Leu 
                165                 170                 175     


Ala Val Leu Thr Glu His Lys Leu Leu Val His Ser Leu Arg Pro Asp 
            180                 185                 190         


Leu Leu Thr Ser Val Cys Glu Ala Leu Val Ser Met Ile Phe Pro Leu 
        195                 200                 205             


His Trp Gln Cys Pro Tyr Ile Pro Leu Cys Pro Leu Val Leu Ala Asp 
    210                 215                 220                 


Val Leu Ser Ala Pro Val Pro Phe Ile Val Gly Ile His Ser Ser Tyr 
225                 230                 235                 240 


Phe Asp Leu His Asp Pro Pro Ala Asp Val Ile Cys Val Asp Leu Asp 
                245                 250                 255     


Thr Asn Thr Leu Phe Gln Thr Glu Glu Lys Lys Leu Leu Ser Pro Arg 
            260                 265                 270         


Thr Leu Pro Arg Arg Pro Tyr Lys Val Leu Leu Ala Thr Leu Thr Asn 
        275                 280                 285             


Leu Tyr Gln Gln Leu Asp Gln Thr Tyr Thr Gly Pro Glu Glu Glu Ala 
    290                 295                 300                 


Ser Leu Glu Phe Leu Leu Thr Asp Tyr Glu Ala Val Cys Gly Arg Arg 
305                 310                 315                 320 


Ala Arg Leu Glu Arg Glu Val Gln Gly Ala Phe Leu Arg Phe Met Ala 
                325                 330                 335     


Cys Leu Leu Lys Gly Tyr Arg Val Phe Leu Arg Pro Leu Thr Gln Ala 
            340                 345                 350         


Pro Ser Glu Gly Ala Arg Asp Val Asp Asn Leu Phe Phe Leu Gln Gly 
        355                 360                 365             


Phe Leu Lys Ser Arg Glu Arg Ser Ser His Lys Leu Tyr Ser Gln Leu 
    370                 375                 380                 


Leu His Thr Gln Met Phe Ser Gln Phe Ile Glu Glu Cys Ser Phe Gly 
385                 390                 395                 400 


Ser Ala Arg His Ala Ala Leu Glu Phe Phe Asp Ser Cys Val Glu Lys 
                405                 410                 415     


Val His Pro Glu Gln Glu Lys Pro Glu Pro Thr Pro Leu Val Glu Leu 
            420                 425                 430         


Glu Glu Leu Ser Gly Ser Glu Leu Thr Val Phe Ile Thr Pro Pro Glu 
        435                 440                 445             


Glu Pro Ala Leu Pro Glu Gly Ser Glu Ser Thr Pro Gln Tyr Cys Tyr 
    450                 455                 460                 


Asp Gly Phe Pro Glu Leu Arg Ala Glu Leu Phe Glu Ser Leu Gln Glu 
465                 470                 475                 480 


Gln Pro Gly Ala Leu Pro Val Pro Gly Pro Ser Arg Ser Ala Pro Ser 
                485                 490                 495     


Ser Pro Ala Pro Arg Arg Thr Lys Gln Glu Met Lys Val Ala Gln Arg 
            500                 505                 510         


Met Ala Gln Lys Ser Ala Ala Val Pro Glu Leu Trp Ala Arg Cys Leu 
        515                 520                 525             


Leu Gly His Cys Tyr Gly Leu Trp Phe Leu Cys Leu Pro Ala Tyr Val 
    530                 535                 540                 


Arg Ser Ala Pro Ser Arg Val Gln Ala Leu His Thr Ala Tyr His Val 
545                 550                 555                 560 


Leu Arg Gln Met Glu Ser Gly Lys Val Val Leu Pro Asp Glu Val Cys 
                565                 570                 575     


Tyr Arg Val Leu Met Gln Leu Cys Ser His Tyr Gly Gln Pro Val Leu 
            580                 585                 590         


Ser Val Arg Val Met Leu Glu Met Arg Gln Ala Gly Ile Val Pro Asn 
        595                 600                 605             


Thr Ile Thr Tyr Gly Tyr Tyr Asn Lys Ala Val Leu Glu Ser Lys Trp 
    610                 615                 620                 


Pro Ser Gly Thr Pro Gly Gly Arg Leu Arg Trp Ala Lys Leu Arg Asn 
625                 630                 635                 640 


Val Val Leu Gly Ala Ala Gln Phe Arg Gln Pro Leu Arg Glu Arg Gln 
                645                 650                 655     


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Glu 
            660                 665                 670         


Gln Val Ser Ala His Gln Glu Ala Gly Ser Ser Gln Ala Glu Pro Tyr 
        675                 680                 685             


Leu Glu Arg Pro Ser Pro Thr Arg Pro Leu Gln Arg Gln Thr Thr Trp 
    690                 695                 700                 


Ala Gly Arg Ser Leu Arg Asp Pro Ala Ser Pro Pro Gly Arg Leu Val 
705                 710                 715                 720 


Lys Ser Gly Ser Leu Gly Ser Ala Arg Gly Ala Gln Pro Thr Val Glu 
                725                 730                 735     


Ala Gly Val Ala His Met Ile Glu Ala Leu Gly Val Leu Glu Pro Arg 
            740                 745                 750         


Gly Ser Pro Val Pro Trp His Asp Gly Ser Leu Ser Asp Leu Ser Leu 
        755                 760                 765             


Thr Gly Glu Glu Pro Leu Pro Gly Gly Ser Pro Gly Gly Ser Gly Ser 
    770                 775                 780                 


Ala Leu Ser Ala Gln Ser Thr Glu Ala Leu Glu Gly Leu Ser Gly Arg 
785                 790                 795                 800 


Gly Pro Lys Ala Gly Gly Arg Gln Asp Glu Ala Gly Thr Pro Arg Arg 
                805                 810                 815     


Gly Leu Gly Ala Arg Leu Gln Gln Leu Leu Thr Pro Ser Arg His Ser 
            820                 825                 830         


Pro Ala Ser Arg Ile Pro Pro Pro Glu Leu Pro Pro Asp Leu Pro Pro 
        835                 840                 845             


Pro Ala Arg Arg Ser Pro Met Asp Ser Leu Leu His Pro Arg Glu Arg 
    850                 855                 860                 


Pro Gly Ser Thr Ala Ser Glu Ser Ser Ala Ser Leu Gly Ser Glu Trp 
865                 870                 875                 880 


Asp Leu Ser Glu Ser Ser Leu Ser Asn Leu Ser Leu Arg Arg Ser Ser 
                885                 890                 895     


Glu Arg Leu Ser Asp Thr Pro Gly Ser Phe Gln Ser Pro Ser Leu Glu 
            900                 905                 910         


Ile Leu Leu Ser Ser Cys Ser Leu Cys Arg Ala Cys Asp Ser Leu Val 
        915                 920                 925             


Tyr Asp Glu Glu Ile Met Ala Gly Trp Ala Pro Asp Asp Ser Asn Leu 
    930                 935                 940                 


Asn Thr Thr Cys Pro Phe Cys Ala Cys Pro Phe Val Pro Leu Leu Ser 
945                 950                 955                 960 


Val Gln Thr Leu Asp Ser Arg Pro Ser Val Pro Ser Pro Lys Ser Ala 
                965                 970                 975     


Gly Ala Ser Gly Ser Lys Asp Ala Pro Val Pro Gly Gly Pro Gly Pro 
            980                 985                 990         


Val Leu Ser Asp Arg Arg Leu Cys  Leu Ala Leu Asp Glu  Pro Gln Leu 
        995                 1000                 1005             


Cys Asn  Gly His Met Gly Gly  Ala Ser Arg Arg Val  Glu Ser Gly 
    1010                 1015                 1020             


Ala Trp  Ala Tyr Leu Ser Pro  Leu Val Leu Arg Lys  Glu Leu Glu 
    1025                 1030                 1035             


Ser Leu  Val Glu Asn Glu Gly  Ser Glu Val Leu Ala  Leu Pro Glu 
    1040                 1045                 1050             


Leu Pro  Ser Ala His Pro Ile  Ile Phe Trp Asn Leu  Leu Trp Tyr 
    1055                 1060                 1065             


Phe Gln  Arg Leu Arg Leu Pro  Ser Ile Leu Pro Gly  Leu Val Leu 
    1070                 1075                 1080             


Ala Ser  Cys Asp Gly Pro Ser  His Ser Gln Ala Pro  Ser Pro Trp 
    1085                 1090                 1095             


Leu Thr  Pro Asp Pro Ala Ser  Val Gln Val Arg Leu  Leu Trp Asp 
    1100                 1105                 1110             


Val Leu  Thr Pro Asp Pro Asn  Ser Cys Pro Pro Leu  Tyr Val Leu 
    1115                 1120                 1125             


Trp Arg  Val His Ser Gln Ile  Pro Gln Arg Val Val  Trp Pro Gly 
    1130                 1135                 1140             


Pro Val  Pro Ala Ser Leu Ser  Leu Ala Leu Leu Glu  Ser Val Leu 
    1145                 1150                 1155             


Arg His  Val Gly Leu Asn Glu  Val His Lys Ala Val  Gly Leu Leu 
    1160                 1165                 1170             


Leu Glu  Thr Leu Gly Pro Pro  Pro Thr Gly Leu His  Leu Gln Arg 
    1175                 1180                 1185             


Gly Ile  Tyr Arg Glu Ile Leu  Phe Leu Thr Met Ala  Ala Leu Gly 
    1190                 1195                 1200             


Lys Asp  His Val Asp Ile Val  Ala Phe Asp Lys Lys  Tyr Lys Ser 
    1205                 1210                 1215             


Ala Phe  Asn Lys Leu Ala Ser  Ser Met Gly Lys Glu  Glu Leu Arg 
    1220                 1225                 1230             


His Arg  Arg Ala Gln Met Pro  Thr Pro Lys Ala Ile  Asp Cys Arg 
    1235                 1240                 1245             


Lys Cys  Phe Gly Ala Pro Pro  Glu Cys 
    1250                 1255         

<210>  762
<211>  5612
<212>  DNA
<213>  Homo sapiens

<400>  762
ggtgggggta gcggcggcgc ccgcggcccg gagcgggggt tgggggagta gagaaagcgg     60

ggcgcgcgga ggaacgctgg gtccccggcg ccgcgggagc tgggaggacc gagccggccg    120

agcgagcagc gcggcagcac agtccccgcg tggcgcagcg cggcggggac gcggggaccg    180

cccggatctc cttccactgc gccccgcgct ctgcggtcct cggccgcctc ttcttccttc    240

actcactgcc cgggcgggag cggcgcccaa gtcgggtgcg ccatgtctgg ggccgggtac    300

agatgcagtg agtgaggggg gggccatggc ggaggagcgg cccccccggc tggtggatta    360

cttcgtggta gctgggcttg cagggaacgg agcacccatc cctgaggaaa cgtgggttcc    420

tgaacccagt gggcccctgc gccctccccg gccagctgag cccatcacag atgtggcagt    480

catcgctagg gcactgggcg aggaagtgcc ccagggctac acatgcatcc aggcttctgc    540

tgggggccac cccttggaac tcagtgctgg acttctgggt ggaactcaac ccgtcatctg    600

ctaccgcagg ggccgtgaca agccccccct cgttgagctg ggggtgttgt atgaggggaa    660

ggaacgtccc aagcctggct tccaagtgct tgacacgaca ccctacagcc actcagcaaa    720

cctggcccct ccaggccccg ggcacccccg cacctacctc acttaccggc gggcagcaga    780

gggggcaggg ctgcatgccc tgggcatcac tgacctctgc ctggtgctgc ccagtaaggg    840

cgagggcact cctcatactt actgccggct gccccgcaac ctcaaccctg gcatgtgggg    900

cccagcagtg tacctgtgct ataaggtggg cctggcgaag gccaacacgc tggtgtacga    960

ggcagagctg ctgggccgct acccggagga ggacaatgag gcgttcccgc tgcccgagtc   1020

agtgcccgtc ttctgcctgc ccatgggggc cactatcgag tgctggcctg cccagaccaa   1080

gtaccccgtg cccgtcttct ccacctttgt gctcacgggt gcagctggtg ataaggtgta   1140

tggtgccgcc ctgcagttct acgaggcgtt cccaagggcc aggctatcag agcgacaggc   1200

acgggcactg ggcctgctga gcgccgtgga gcggggtcgg gcactggggg gcagagctgt   1260

gcgcagccgg cgtgccatcg ctgtgctgtc ccgctggcct gccttccctg ccttccgcgc   1320

cttcctcacc ttcctttacc gctactccgt ctcaggcccc caccgcctac ccttggaagc   1380

gcacatctcc cacttcattc acaacgttcc cttcccttcc ccacagagac cccgcatcct   1440

agtgcagatg tctccctatg acaacttgct cctctgtcag cctgtatcct cacccctgcc   1500

cctcagtggt gccagcttcc tgcagctgct gcagagcctg ggccctgagc tggctatcac   1560

actgctgctg gctgtgctca cagagcacaa gctgctagtc cactcgctgc ggccagacct   1620

gctcaccagc gtctgtgagg ccctcgtctc gatgatcttc ccactgcact ggcagtgccc   1680

ctacattcct ctgtgcccgc tggtgctggc agatgtgctg agtgccccag tgcccttcat   1740

tgtgggtatc cactccagct actttgatct gcatgacccg cctgctgatg tcatctgtgt   1800

agaccttgat accaacacgc tcttccagac tgaggaaaag aagctcctct cccctcggac   1860

cctgccccgc agaccctaca aggttctgct ggccacactg acaaacctgt accagcagct   1920

ggaccagaca tacactggac ctgaggagga agcatccctg gagttcctac tgacagacta   1980

cgaggcagtg tgtggccgca gggcccggct ggagcgcgaa gtccaaggag ccttcctccg   2040

cttcatggcc tgtctgctca agggctaccg ggtcttcctg cgcccactca cccaggcccc   2100

ctccgaggga gctcgtgatg ttgacaacct tttcttcctg cagggcttcc tcaaatcccg   2160

ggaacgctcc agccacaaac tttactctca gctgctgcac acacagatgt tctcacagtt   2220

cattgaggag tgctcttttg gctctgctcg ccatgctgcc cttgaattct ttgactcttg   2280

tgttgaaaag gtccacccag agcaggagaa gcctgagccg acacccttag tggagctaga   2340

ggagctgtca ggaagtgagc tcactgtctt tatcacacct cccgaggagc ctgccttacc   2400

agagggcagt gaatccactc cccagtactg ctatgatgga ttcccagagc tacgggctga   2460

gttgtttgag tctcttcaag agcaacctgg ggccctgcct gtgccaggcc cttcccgtag   2520

cgcccccagc agtcctgctc ctcgccgtac caaacaggag atgaaagttg cacagcggat   2580

ggcacagaag tcagcagctg tgcctgagct gtgggcccgg tgcctgctgg ggcactgcta   2640

tgggctgtgg ttcctgtgtc tgcctgccta tgtgcggtcg gcaccctccc gagtgcaggc   2700

actgcacaca gcctaccatg tgctgcgcca gatggagagc ggcaaggtgg tgctccctga   2760

tgaggtgtgt taccgggtac tgatgcagct ctgctcacac tatgggcagc ctgtgctgtc   2820

tgtgcgggtc atgctggaga tgcgtcaggc aggcattgtg cccaacacca tcacctatgg   2880

ctactacaat aaggctgtgt tggaaagcaa gtggccgtct ggcacaccag gtgggcgtct   2940

gcgctgggcc aagctccgga atgttgtcct gggggctgct cagttccgcc agcccttgag   3000

agaacggcaa cagcagcagc agcagcaaca gcagcagcag cagcagcagc agcaggagca   3060

ggtgtcagca catcaagagg caggcagctc ccaggcagag ccctatttgg agcgcccttc   3120

ccctactcgc cctcttcagc gccagactac ttgggctggg cgaagtctga gagacccagc   3180

ctcaccccct ggacgcctgg tgaagagtgg tagcctgggc agtgcccgag gggcacagcc   3240

cactgtggag gccggtgtgg cccacatgat agaggccttg ggggtcctgg aaccccgggg   3300

atcacctgtg ccctggcacg atggaagtct ctcagacctg agcctgacag gggaggagcc   3360

gctccctgga ggcagcccag ggggctcagg ctcagccctg agtgcccagt ccactgaggc   3420

cctggaaggg ctaagtgggc ggggacccaa ggctggtggg cgacaggatg aggcaggcac   3480

cccccgacga gggctgggtg cccgcctcca acagctgctc actccttccc gccactcccc   3540

tgcctcccgc attcccccac ctgagctgcc tcctgacctg ccacccccag cccgccgcag   3600

ccccatggac agtcttctgc acccccggga gcgccctgga tccactgcct ccgagagctc   3660

agcctctctg ggcagtgagt gggacctctc agaatcttct ctcagcaacc tgagtcttcg   3720

ccgttcctca gagcgcctca gtgacacccc tggatccttc cagtcacctt ccctggaaat   3780

tctgctgtcc agctgctccc tgtgccgtgc ctgtgattcg ctggtgtatg atgaggaaat   3840

catggctggc tgggcacctg atgactctaa cctcaacaca acctgcccct tctgcgcctg   3900

cccctttgtg cccctgctca gtgtccagac ccttgattcc cggcccagtg tccccagccc   3960

caaatctgct ggtgccagtg gcagcaaaga tgctcctgtc cctggtggtc ctggccctgt   4020

gctcagtgac cgaaggctct gccttgctct ggatgagccc cagctctgca acgggcacat   4080

ggggggagcc tcccggcggg ttgagagtgg ggcatgggca tacctgagcc ccctggtgct   4140

gcgtaaggag ctggagtcgc tggtagagaa cgagggcagt gaggtgctgg cgttgcctga   4200

actgccctct gcccacccca tcatcttctg gaaccttttg tggtatttcc aacggctacg   4260

cctgcccagt attctaccag gcctggtgct ggcctcctgt gatgggcctt cgcactccca   4320

ggccccatct ccttggctaa cccctgatcc agcctctgtt caggtacggc tgctgtggga   4380

tgtactgacc cctgacccca atagctgccc acctctctat gtgctctgga gggtccacag   4440

ccagatcccc cagcgggtgg tatggccagg ccctgtacct gcatccctta gtttggcact   4500

gttggagtca gtgctgcgcc atgttggact caatgaagtg cacaaggctg tggggctcct   4560

gctggaaact ctagggcccc cacccactgg cctgcacctg cagaggggaa tctaccgtga   4620

gatattattc ctgacaatgg ctgctctggg caaggaccac gtggacatag tggccttcga   4680

taagaagtac aagtctgcct ttaacaagct ggccagcagc atgggcaagg aggagctgag   4740

gcaccggcgg gcgcagatgc ccactcccaa ggccattgac tgccgaaaat gttttggagc   4800

acctccagaa tgctagagac cttaagcttc cctctccagc ctagggtggg gaagtgagga   4860

agaagggatt ctagagttaa actgcttccc tgttgccttc atggagttgg gaacaggctg   4920

ggaaggatgc ccagtcaaag gctccaagcg aggacaacag gaagagggat ccactgttac   4980

caaaagtcct gattccccca tcaccaacct acccagtttg ttcgtgctga tgttggggga   5040

gatctggggg gagttggtac agctctgttc ttcccttgtc ctataccggg aactcccctc   5100

cagggtaccc acagatctgc attgccctgg tcattttaga agtttttgtt ttaaaaaaca   5160

actggaaaga tgcagagcta ctgagccttt gccctgaatg ggaggtaggg atgtcattct   5220

ccaccaataa tggtccctct tccctgacgt tgctgaagga gcccaaggct ctccatgcct   5280

ttctacctaa gtgtttgtat tttattttaa attatttatt ctggagccac agcccccttg   5340

cttatgaggt tcttatggag agtgagaaag ggaagggaaa tagggcacca tggtccggtg   5400

gtttgtagtt ccttcaaagt caggcactgg gagctagagg agtctcaagc tccccttagg   5460

aagaactggt gccccctcca gtcctaattt ttcttgcctg ccccgccttg gggaatgcct   5520

cacccaccca ggtcctgacc tgtgcaataa ggattgttcc ctgcgaagtt ttgttggatg   5580

taaatatagt aaaagctgct tctgtctttt tc                                 5612


<210>  763
<211>  1496
<212>  PRT
<213>  Homo sapiens

<400>  763


Met Ala Glu Glu Arg Pro Pro Arg Leu Val Asp Tyr Phe Val Val Ala 
1               5                   10                  15      


Gly Leu Ala Gly Asn Gly Ala Pro Ile Pro Glu Glu Thr Trp Val Pro 
            20                  25                  30          


Glu Pro Ser Gly Pro Leu Arg Pro Pro Arg Pro Ala Glu Pro Ile Thr 
        35                  40                  45              


Asp Val Ala Val Ile Ala Arg Ala Leu Gly Glu Glu Val Pro Gln Gly 
    50                  55                  60                  


Tyr Thr Cys Ile Gln Ala Ser Ala Gly Gly His Pro Leu Glu Leu Ser 
65                  70                  75                  80  


Ala Gly Leu Leu Gly Gly Thr Gln Pro Val Ile Cys Tyr Arg Arg Gly 
                85                  90                  95      


Arg Asp Lys Pro Pro Leu Val Glu Leu Gly Val Leu Tyr Glu Gly Lys 
            100                 105                 110         


Glu Arg Pro Lys Pro Gly Phe Gln Val Leu Asp Thr Thr Pro Tyr Ser 
        115                 120                 125             


His Ser Ala Asn Leu Ala Pro Pro Gly Pro Gly His Pro Arg Thr Tyr 
    130                 135                 140                 


Leu Thr Tyr Arg Arg Ala Ala Glu Gly Ala Gly Leu His Ala Leu Gly 
145                 150                 155                 160 


Ile Thr Asp Leu Cys Leu Val Leu Pro Ser Lys Gly Glu Gly Thr Pro 
                165                 170                 175     


His Thr Tyr Cys Arg Leu Pro Arg Asn Leu Asn Pro Gly Met Trp Gly 
            180                 185                 190         


Pro Ala Val Tyr Leu Cys Tyr Lys Val Gly Leu Ala Lys Ala Asn Thr 
        195                 200                 205             


Leu Val Tyr Glu Ala Glu Leu Leu Gly Arg Tyr Pro Glu Glu Asp Asn 
    210                 215                 220                 


Glu Ala Phe Pro Leu Pro Glu Ser Val Pro Val Phe Cys Leu Pro Met 
225                 230                 235                 240 


Gly Ala Thr Ile Glu Cys Trp Pro Ala Gln Thr Lys Tyr Pro Val Pro 
                245                 250                 255     


Val Phe Ser Thr Phe Val Leu Thr Gly Ala Ala Gly Asp Lys Val Tyr 
            260                 265                 270         


Gly Ala Ala Leu Gln Phe Tyr Glu Ala Phe Pro Arg Ala Arg Leu Ser 
        275                 280                 285             


Glu Arg Gln Ala Arg Ala Leu Gly Leu Leu Ser Ala Val Glu Arg Gly 
    290                 295                 300                 


Arg Ala Leu Gly Gly Arg Ala Val Arg Ser Arg Arg Ala Ile Ala Val 
305                 310                 315                 320 


Leu Ser Arg Trp Pro Ala Phe Pro Ala Phe Arg Ala Phe Leu Thr Phe 
                325                 330                 335     


Leu Tyr Arg Tyr Ser Val Ser Gly Pro His Arg Leu Pro Leu Glu Ala 
            340                 345                 350         


His Ile Ser His Phe Ile His Asn Val Pro Phe Pro Ser Pro Gln Arg 
        355                 360                 365             


Pro Arg Ile Leu Val Gln Met Ser Pro Tyr Asp Asn Leu Leu Leu Cys 
    370                 375                 380                 


Gln Pro Val Ser Ser Pro Leu Pro Leu Ser Gly Ala Ser Phe Leu Gln 
385                 390                 395                 400 


Leu Leu Gln Ser Leu Gly Pro Glu Leu Ala Ile Thr Leu Leu Leu Ala 
                405                 410                 415     


Val Leu Thr Glu His Lys Leu Leu Val His Ser Leu Arg Pro Asp Leu 
            420                 425                 430         


Leu Thr Ser Val Cys Glu Ala Leu Val Ser Met Ile Phe Pro Leu His 
        435                 440                 445             


Trp Gln Cys Pro Tyr Ile Pro Leu Cys Pro Leu Val Leu Ala Asp Val 
    450                 455                 460                 


Leu Ser Ala Pro Val Pro Phe Ile Val Gly Ile His Ser Ser Tyr Phe 
465                 470                 475                 480 


Asp Leu His Asp Pro Pro Ala Asp Val Ile Cys Val Asp Leu Asp Thr 
                485                 490                 495     


Asn Thr Leu Phe Gln Thr Glu Glu Lys Lys Leu Leu Ser Pro Arg Thr 
            500                 505                 510         


Leu Pro Arg Arg Pro Tyr Lys Val Leu Leu Ala Thr Leu Thr Asn Leu 
        515                 520                 525             


Tyr Gln Gln Leu Asp Gln Thr Tyr Thr Gly Pro Glu Glu Glu Ala Ser 
    530                 535                 540                 


Leu Glu Phe Leu Leu Thr Asp Tyr Glu Ala Val Cys Gly Arg Arg Ala 
545                 550                 555                 560 


Arg Leu Glu Arg Glu Val Gln Gly Ala Phe Leu Arg Phe Met Ala Cys 
                565                 570                 575     


Leu Leu Lys Gly Tyr Arg Val Phe Leu Arg Pro Leu Thr Gln Ala Pro 
            580                 585                 590         


Ser Glu Gly Ala Arg Asp Val Asp Asn Leu Phe Phe Leu Gln Gly Phe 
        595                 600                 605             


Leu Lys Ser Arg Glu Arg Ser Ser His Lys Leu Tyr Ser Gln Leu Leu 
    610                 615                 620                 


His Thr Gln Met Phe Ser Gln Phe Ile Glu Glu Cys Ser Phe Gly Ser 
625                 630                 635                 640 


Ala Arg His Ala Ala Leu Glu Phe Phe Asp Ser Cys Val Glu Lys Val 
                645                 650                 655     


His Pro Glu Gln Glu Lys Pro Glu Pro Thr Pro Leu Val Glu Leu Glu 
            660                 665                 670         


Glu Leu Ser Gly Ser Glu Leu Thr Val Phe Ile Thr Pro Pro Glu Glu 
        675                 680                 685             


Pro Ala Leu Pro Glu Gly Ser Glu Ser Thr Pro Gln Tyr Cys Tyr Asp 
    690                 695                 700                 


Gly Phe Pro Glu Leu Arg Ala Glu Leu Phe Glu Ser Leu Gln Glu Gln 
705                 710                 715                 720 


Pro Gly Ala Leu Pro Val Pro Gly Pro Ser Arg Ser Ala Pro Ser Ser 
                725                 730                 735     


Pro Ala Pro Arg Arg Thr Lys Gln Glu Met Lys Val Ala Gln Arg Met 
            740                 745                 750         


Ala Gln Lys Ser Ala Ala Val Pro Glu Leu Trp Ala Arg Cys Leu Leu 
        755                 760                 765             


Gly His Cys Tyr Gly Leu Trp Phe Leu Cys Leu Pro Ala Tyr Val Arg 
    770                 775                 780                 


Ser Ala Pro Ser Arg Val Gln Ala Leu His Thr Ala Tyr His Val Leu 
785                 790                 795                 800 


Arg Gln Met Glu Ser Gly Lys Val Val Leu Pro Asp Glu Val Cys Tyr 
                805                 810                 815     


Arg Val Leu Met Gln Leu Cys Ser His Tyr Gly Gln Pro Val Leu Ser 
            820                 825                 830         


Val Arg Val Met Leu Glu Met Arg Gln Ala Gly Ile Val Pro Asn Thr 
        835                 840                 845             


Ile Thr Tyr Gly Tyr Tyr Asn Lys Ala Val Leu Glu Ser Lys Trp Pro 
    850                 855                 860                 


Ser Gly Thr Pro Gly Gly Arg Leu Arg Trp Ala Lys Leu Arg Asn Val 
865                 870                 875                 880 


Val Leu Gly Ala Ala Gln Phe Arg Gln Pro Leu Arg Glu Arg Gln Gln 
                885                 890                 895     


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Glu Gln 
            900                 905                 910         


Val Ser Ala His Gln Glu Ala Gly Ser Ser Gln Ala Glu Pro Tyr Leu 
        915                 920                 925             


Glu Arg Pro Ser Pro Thr Arg Pro Leu Gln Arg Gln Thr Thr Trp Ala 
    930                 935                 940                 


Gly Arg Ser Leu Arg Asp Pro Ala Ser Pro Pro Gly Arg Leu Val Lys 
945                 950                 955                 960 


Ser Gly Ser Leu Gly Ser Ala Arg Gly Ala Gln Pro Thr Val Glu Ala 
                965                 970                 975     


Gly Val Ala His Met Ile Glu Ala Leu Gly Val Leu Glu Pro Arg Gly 
            980                 985                 990         


Ser Pro Val Pro Trp His Asp Gly  Ser Leu Ser Asp Leu  Ser Leu Thr 
        995                 1000                 1005             


Gly Glu  Glu Pro Leu Pro Gly  Gly Ser Pro Gly Gly  Ser Gly Ser 
    1010                 1015                 1020             


Ala Leu  Ser Ala Gln Ser Thr  Glu Ala Leu Glu Gly  Leu Ser Gly 
    1025                 1030                 1035             


Arg Gly  Pro Lys Ala Gly Gly  Arg Gln Asp Glu Ala  Gly Thr Pro 
    1040                 1045                 1050             


Arg Arg  Gly Leu Gly Ala Arg  Leu Gln Gln Leu Leu  Thr Pro Ser 
    1055                 1060                 1065             


Arg His  Ser Pro Ala Ser Arg  Ile Pro Pro Pro Glu  Leu Pro Pro 
    1070                 1075                 1080             


Asp Leu  Pro Pro Pro Ala Arg  Arg Ser Pro Met Asp  Ser Leu Leu 
    1085                 1090                 1095             


His Pro  Arg Glu Arg Pro Gly  Ser Thr Ala Ser Glu  Ser Ser Ala 
    1100                 1105                 1110             


Ser Leu  Gly Ser Glu Trp Asp  Leu Ser Glu Ser Ser  Leu Ser Asn 
    1115                 1120                 1125             


Leu Ser  Leu Arg Arg Ser Ser  Glu Arg Leu Ser Asp  Thr Pro Gly 
    1130                 1135                 1140             


Ser Phe  Gln Ser Pro Ser Leu  Glu Ile Leu Leu Ser  Ser Cys Ser 
    1145                 1150                 1155             


Leu Cys  Arg Ala Cys Asp Ser  Leu Val Tyr Asp Glu  Glu Ile Met 
    1160                 1165                 1170             


Ala Gly  Trp Ala Pro Asp Asp  Ser Asn Leu Asn Thr  Thr Cys Pro 
    1175                 1180                 1185             


Phe Cys  Ala Cys Pro Phe Val  Pro Leu Leu Ser Val  Gln Thr Leu 
    1190                 1195                 1200             


Asp Ser  Arg Pro Ser Val Pro  Ser Pro Lys Ser Ala  Gly Ala Ser 
    1205                 1210                 1215             


Gly Ser  Lys Asp Ala Pro Val  Pro Gly Gly Pro Gly  Pro Val Leu 
    1220                 1225                 1230             


Ser Asp  Arg Arg Leu Cys Leu  Ala Leu Asp Glu Pro  Gln Leu Cys 
    1235                 1240                 1245             


Asn Gly  His Met Gly Gly Ala  Ser Arg Arg Val Glu  Ser Gly Ala 
    1250                 1255                 1260             


Trp Ala  Tyr Leu Ser Pro Leu  Val Leu Arg Lys Glu  Leu Glu Ser 
    1265                 1270                 1275             


Leu Val  Glu Asn Glu Gly Ser  Glu Val Leu Ala Leu  Pro Glu Leu 
    1280                 1285                 1290             


Pro Ser  Ala His Pro Ile Ile  Phe Trp Asn Leu Leu  Trp Tyr Phe 
    1295                 1300                 1305             


Gln Arg  Leu Arg Leu Pro Ser  Ile Leu Pro Gly Leu  Val Leu Ala 
    1310                 1315                 1320             


Ser Cys  Asp Gly Pro Ser His  Ser Gln Ala Pro Ser  Pro Trp Leu 
    1325                 1330                 1335             


Thr Pro  Asp Pro Ala Ser Val  Gln Val Arg Leu Leu  Trp Asp Val 
    1340                 1345                 1350             


Leu Thr  Pro Asp Pro Asn Ser  Cys Pro Pro Leu Tyr  Val Leu Trp 
    1355                 1360                 1365             


Arg Val  His Ser Gln Ile Pro  Gln Arg Val Val Trp  Pro Gly Pro 
    1370                 1375                 1380             


Val Pro  Ala Ser Leu Ser Leu  Ala Leu Leu Glu Ser  Val Leu Arg 
    1385                 1390                 1395             


His Val  Gly Leu Asn Glu Val  His Lys Ala Val Gly  Leu Leu Leu 
    1400                 1405                 1410             


Glu Thr  Leu Gly Pro Pro Pro  Thr Gly Leu His Leu  Gln Arg Gly 
    1415                 1420                 1425             


Ile Tyr  Arg Glu Ile Leu Phe  Leu Thr Met Ala Ala  Leu Gly Lys 
    1430                 1435                 1440             


Asp His  Val Asp Ile Val Ala  Phe Asp Lys Lys Tyr  Lys Ser Ala 
    1445                 1450                 1455             


Phe Asn  Lys Leu Ala Ser Ser  Met Gly Lys Glu Glu  Leu Arg His 
    1460                 1465                 1470             


Arg Arg  Ala Gln Met Pro Thr  Pro Lys Ala Ile Asp  Cys Arg Lys 
    1475                 1480                 1485             


Cys Phe  Gly Ala Pro Pro Glu  Cys 
    1490                 1495     

<210>  764
<211>  1262
<212>  DNA
<213>  Homo sapiens

<400>  764
tgaacacaca tagcacacac tcaccctgtc caaggcagga gatggggagg aggtgggagg     60

ggctggggaa ggggcatggg ctccagagtg ctggcggcca gacagcacct acttcccgac    120

tctccctgcc cacagattct gctgtccagc tgctccctgt gccgtgcctg tgattcgctg    180

gtgtatgatg aggaaatcat ggctggctgg gcacctgatg actctaacct caacacaacc    240

tgccccttct gcgcctgccc ctttgtgccc ctgctcagtg tccagaccct tgattcccgg    300

cccagtgtcc ccagccccaa atctgctggt gccagtggca gcaaagatgc tcctgtccct    360

ggtggtcctg gccctgtgct cagtgaccga aggctctgcc ttgctctgga tgagccccag    420

ctctgcaacg ggcacatggg ggtaagggct gggccaaagg ggcatgagga acgggaatgt    480

tgccctgtgt ggggcctgtg gggtgccagg gagagatggg cacatctctt gcccttgagg    540

gcaaggggca tcccaaaagc tgttggatgt ggtggctcag tgggaggcaa ggctctgggg    600

atgtacatgc cctctactgc cctccccctt tgtgcctgat agggagcctc ccggcgggtt    660

gagagtgggg catgggcata cctgagcccc ctggtgctgc gtaaggagct ggagtcgctg    720

gtagagaacg agggcagtga ggtgctggcg ttgcctgaac tgccctctgc ccaccccatc    780

atcttctgga accttttgtg gtatttccaa cggctacgcc tgcccagtat tctaccaggc    840

ctggtgctgg cctcctgtga tgggccttcg cactcccagg tcagtgcccc catgtggccc    900

ctgtttccta agtgcctccc tcatctctca gccatttgtc cactgtgtcc ttggcactgt    960

agaaagagca tagactggcc aggcacggtg gctcatgcct gtaatcccag cactttggga   1020

ggccgaggtg ggcgaatcac ctgaggtcag gagttcgaga ccagcctgac caactgggag   1080

aaaccctgtc tctactaaaa atacaaaaaa aattagccag gcttggtggt gcatgcctgt   1140

aatcccagct actcgggagg ctgaggtggg agaattgctt gaacctggga ggcggaggtt   1200

gtggtgagcc gagatcgcgc cattgccctc cagcctgagc aacaagagca aaactccgtc   1260

tc                                                                  1262


<210>  765
<211>  187
<212>  PRT
<213>  Homo sapiens

<400>  765


Met Gly Ser Arg Val Leu Ala Ala Arg Gln His Leu Leu Pro Asp Ser 
1               5                   10                  15      


Pro Cys Pro Gln Ile Leu Leu Ser Ser Cys Ser Leu Cys Arg Ala Cys 
            20                  25                  30          


Asp Ser Leu Val Tyr Asp Glu Glu Ile Met Ala Gly Trp Ala Pro Asp 
        35                  40                  45              


Asp Ser Asn Leu Asn Thr Thr Cys Pro Phe Cys Ala Cys Pro Phe Val 
    50                  55                  60                  


Pro Leu Leu Ser Val Gln Thr Leu Asp Ser Arg Pro Ser Val Pro Ser 
65                  70                  75                  80  


Pro Lys Ser Ala Gly Ala Ser Gly Ser Lys Asp Ala Pro Val Pro Gly 
                85                  90                  95      


Gly Pro Gly Pro Val Leu Ser Asp Arg Arg Leu Cys Leu Ala Leu Asp 
            100                 105                 110         


Glu Pro Gln Leu Cys Asn Gly His Met Gly Val Arg Ala Gly Pro Lys 
        115                 120                 125             


Gly His Glu Glu Arg Glu Cys Cys Pro Val Trp Gly Leu Trp Gly Ala 
    130                 135                 140                 


Arg Glu Arg Trp Ala His Leu Leu Pro Leu Arg Ala Arg Gly Ile Pro 
145                 150                 155                 160 


Lys Ala Val Gly Cys Gly Gly Ser Val Gly Gly Lys Ala Leu Gly Met 
                165                 170                 175     


Tyr Met Pro Ser Thr Ala Leu Pro Leu Cys Ala 
            180                 185         

<210>  766
<211>  4779
<212>  DNA
<213>  Homo sapiens

<400>  766
atggcggagg agcggccccc ccggctggtg gattacttcg tggtagctgg gcttgcaggg     60

aacggagcac ccatccctga ggaaacgtgg gttcctgaac ccagtgggcc cctgcgccct    120

ccccggccag ctgagcccat cacagatgtg gcagtcatcg ctagggcact gggcgaggaa    180

gtgccccagg gctacacatg catccaggct tctgctgggg gccacccctt ggaactcagt    240

gctggacttc tgggtggaac tcaacccgtc atctgctacc gcaggggccg tgacaagccc    300

cccctcgttg agctgggggt gttgtatgag gggaaggaac gtcccaagcc tggcttccaa    360

gtgcttgaca cgacacccta cagccactca gcaaacctgg cccctccagg ccccgggcac    420

ccccgcacct acctcactta ccggcgggca gcagaggggg cagggctgca tgccctgggc    480

atcactgacc tctgcctggt gctgcccagt aagggcgagg gcactcctca tacttactgc    540

cggctgcccc gcaacctcaa ccctggcatg tggggcccag cagtgtacct gtgctataag    600

gtgggcctgg cgaaggccaa cacgctggtg tacgaggcag gtgagtggcc cctttatccc    660

tccaatcctg tgaccctaca tccctttgcc ctggtgcctc ttggcaggca ccttaagtgt    720

ccccagagtt tactttctct ttgctactcg ggccttctct gggatccctt ggttcatttc    780

ccttggagtc tgatggaccc tgctcctttt gggtaccccc aactatgctg ggggtgcaga    840

gctgctgggc cgctacccgg aggaggacaa tgaggcgttc ccgctgcccg agtcagtgcc    900

cgtcttctgc ctgcccatgg gggccactat cgagtgctgg cctgcccaga ccaagtaccc    960

cgtgcccgtc ttctccacct ttgtgctcac gggtgcagct ggtgataagg tgtatggtgc   1020

cgccctgcag ttctacgagg cgttcccaag ggccaggcta tcagagcgac aggcacgggc   1080

actgggcctg ctgagcgccg tggagcgggg tcgggcactg gggggcagag ctgtgcgcag   1140

ccggcgtgcc atcgctgtgc tgtcccgctg gcctgccttc cctgccttcc gcgccttcct   1200

caccttcctt taccgctact ccgtctcagg cccccaccgc ctacccttgg aagcgcacat   1260

ctcccacttc attcacaacg ttcccttccc ttccccacag agaccccgca tcctagtgca   1320

gatgtctccc tatgacaact tgctcctctg tcagcctgta tcctcacccc tgcccctcag   1380

tggtgccagc ttcctgcagc tgctgcagag cctgggccct gagctggcta tcacactgct   1440

gctggctgtg ctcacagagc acaagctgct agtccactcg ctgcggccag acctgctcac   1500

cagcgtctgt gaggccctcg tctcgatgat cttcccactg cactggcagt gcccctacat   1560

tcctctgtgc ccgctggtgc tggcagatgt gctgagtgcc ccagtgccct tcattgtggg   1620

tatccactcc agctactttg atctgcatga cccgcctgct gatgtcatct gtgtagacct   1680

tgataccaac acgctcttcc agactgagga aaagaagctc ctctcccctc ggaccctgcc   1740

ccgcagaccc tacaaggttc tgctggccac actgacaaac ctgtaccagc agctggacca   1800

gacatacact ggacctgagg aggaagcatc cctggagttc ctactgacag actacgaggc   1860

agtgtgtggc cgcagggccc ggctggagcg cgaagtccaa ggagccttcc tccgcttcat   1920

ggcctgtctg ctcaagggct accgggtctt cctgcgccca ctcacccagg ccccctccga   1980

gggagctcgt gatgttgaca accttttctt cctgcagggc ttcctcaaat cccgggaacg   2040

ctccagccac aaactttact ctcagctgct gcacacacag atgttctcac agttcattga   2100

ggagtgctct tttggctctg ctcgccatgc tgcccttgaa ttctttgact cttgtgttga   2160

aaaggtccac ccagagcagg agaagcctga gccgacaccc ttagtggagc tagaggagct   2220

gtcaggaagt gagctcactg tctttatcac acctcccgag gagcctgcct taccagaggg   2280

cagtgaatcc actccccagt actgctatga tggattccca gagctacggg ctgagttgtt   2340

tgagtctctt caagagcaac ctggggccct gcctgtgcca ggcccttccc gtagcgcccc   2400

cagcagtcct gctcctcgcc gtaccaaaca ggagatgaaa gttgcacagc ggatggcaca   2460

gaagtcagca gctgtgcctg agctgtgggc ccggtgcctg ctggggcact gctatgggct   2520

gtggttcctg tgtctgcctg cctatgtgcg gtcggcaccc tcccgagtgc aggcactgca   2580

cacagcctac catgtgctgc gccagatgga gagcggcaag gtggtgctcc ctgatgaggt   2640

gtgttaccgg gtactgatgc agctctgctc acactatggg cagcctgtgc tgtctgtgcg   2700

ggtcatgctg gagatgcgtc aggcaggcat tgtgcccaac accatcacct atggctacta   2760

caataaggct gtgttggaaa gcaagtggcc gtctggcaca ccaggtgggc gtctgcgctg   2820

ggccaagctc cggaatgttg tcctgggggc tgctcagttc cgccagccct tgagagaacg   2880

gcaacagcag cagcagcagc aacagcagca gcagcagcag cagcagcagg agcaggtgtc   2940

agcacatcaa gaggcaggca gctcccaggc agagccctat ttggagcgcc cttcccctac   3000

tcgccctctt cagcgccaga ctacttgggc tgggcgaagt ctgagagacc cagcctcacc   3060

ccctggacgc ctggtgaaga gtggtagcct gggcagtgcc cgaggggcac agcccactgt   3120

ggaggccggt gtggcccaca tgatagaggc cttgggggtc ctggaacccc ggggatcacc   3180

tgtgccctgg cacgatggaa gtctctcaga cctgagcctg acaggggagg agccgctccc   3240

tggaggcagc ccagggggct caggctcagc cctgagtgcc cagtccactg aggccctgga   3300

agggctaagt gggcggggac ccaaggctgg tgggcgacag gatgaggcag gcaccccccg   3360

acgagggctg ggtgcccgcc tccaacagct gctcactcct tcccgccact cccctgcctc   3420

ccgcattccc ccacctgagc tgcctcctga cctgccaccc ccagcccgcc gcagccccat   3480

ggacagtctt ctgcaccccc gggagcgccc tggatccact gcctccgaga gctcagcctc   3540

tctgggcagt gagtgggacc tctcagaatc ttctctcagc aacctgagtc ttcgccgttc   3600

ctcagagcgc ctcagtgaca cccctggatc cttccagtca ccttccctgg aaattctgct   3660

gtccagctgc tccctgtgcc gtgcctgtga ttcgctggtg tatgatgagg aaatcatggc   3720

tggctgggca cctgatgact ctaacctcaa cacaacctgc cccttctgcg cctgcccctt   3780

tgtgcccctg ctcagtgtcc agacccttga ttcccggccc agtgtcccca gccccaaatc   3840

tgctggtgcc agtggcagca aagatgctcc tgtccctggt ggtcctggcc ctgtgctcag   3900

tgaccgaagg ctctgccttg ctctggatga gccccagctc tgcaacgggc acatgggggt   3960

aagggctggg ccaaaggggc atgaggaacg ggaatgttgc cctgtgtggg gcctgtgggg   4020

tgccagggag agatgggcac atctcttgcc cttgagggca aggggcatcc caaaagctgt   4080

tggatgtggt ggctcagtgg gaggcaaggc tctggggatg tacatgccct ctactgccct   4140

ccccctttgt gcctgatagg gagcctcccg gcgggttgag agtggggcat gggcatacct   4200

gagccccctg gtgctgcgta aggagctgga gtcgctggta gagaacgagg gcagtgaggt   4260

gctggcgttg cctgaactgc cctctgccca ccccatcatc ttctggaacc ttttgtggta   4320

tttccaacgg ctacgcctgc ccagtattct accaggcctg gtgctggcct cctgtgatgg   4380

gccttcgcac tcccaggtca gtgcccccat gtggcccctg tttcctaagt gcctccctca   4440

tctctcagcc atttgtccac tgtgtccttg gcactgtaga aagagcatag actggccagg   4500

cacggtggct catgcctgta atcccagcac tttgggaggc cgaggtgggc gaatcacctg   4560

aggtcaggag ttcgagacca gcctgaccaa ctgggagaaa ccctgtctct actaaaaata   4620

caaaaaaaat tagccaggct tggtggtgca tgcctgtaat cccagctact cgggaggctg   4680

aggtgggaga attgcttgaa cctgggaggc ggaggttgtg gtgagccgag atcgcgccat   4740

tgccctccag cctgagcaac aagagcaaaa ctccgtctc                          4779


<210>  767
<211>  1079
<212>  PRT
<213>  Homo sapiens

<400>  767


Met Gly Ala Thr Ile Glu Cys Trp Pro Ala Gln Thr Lys Tyr Pro Val 
1               5                   10                  15      


Pro Val Phe Ser Thr Phe Val Leu Thr Gly Ala Ala Gly Asp Lys Val 
            20                  25                  30          


Tyr Gly Ala Ala Leu Gln Phe Tyr Glu Ala Phe Pro Arg Ala Arg Leu 
        35                  40                  45              


Ser Glu Arg Gln Ala Arg Ala Leu Gly Leu Leu Ser Ala Val Glu Arg 
    50                  55                  60                  


Gly Arg Ala Leu Gly Gly Arg Ala Val Arg Ser Arg Arg Ala Ile Ala 
65                  70                  75                  80  


Val Leu Ser Arg Trp Pro Ala Phe Pro Ala Phe Arg Ala Phe Leu Thr 
                85                  90                  95      


Phe Leu Tyr Arg Tyr Ser Val Ser Gly Pro His Arg Leu Pro Leu Glu 
            100                 105                 110         


Ala His Ile Ser His Phe Ile His Asn Val Pro Phe Pro Ser Pro Gln 
        115                 120                 125             


Arg Pro Arg Ile Leu Val Gln Met Ser Pro Tyr Asp Asn Leu Leu Leu 
    130                 135                 140                 


Cys Gln Pro Val Ser Ser Pro Leu Pro Leu Ser Gly Ala Ser Phe Leu 
145                 150                 155                 160 


Gln Leu Leu Gln Ser Leu Gly Pro Glu Leu Ala Ile Thr Leu Leu Leu 
                165                 170                 175     


Ala Val Leu Thr Glu His Lys Leu Leu Val His Ser Leu Arg Pro Asp 
            180                 185                 190         


Leu Leu Thr Ser Val Cys Glu Ala Leu Val Ser Met Ile Phe Pro Leu 
        195                 200                 205             


His Trp Gln Cys Pro Tyr Ile Pro Leu Cys Pro Leu Val Leu Ala Asp 
    210                 215                 220                 


Val Leu Ser Ala Pro Val Pro Phe Ile Val Gly Ile His Ser Ser Tyr 
225                 230                 235                 240 


Phe Asp Leu His Asp Pro Pro Ala Asp Val Ile Cys Val Asp Leu Asp 
                245                 250                 255     


Thr Asn Thr Leu Phe Gln Thr Glu Glu Lys Lys Leu Leu Ser Pro Arg 
            260                 265                 270         


Thr Leu Pro Arg Arg Pro Tyr Lys Val Leu Leu Ala Thr Leu Thr Asn 
        275                 280                 285             


Leu Tyr Gln Gln Leu Asp Gln Thr Tyr Thr Gly Pro Glu Glu Glu Ala 
    290                 295                 300                 


Ser Leu Glu Phe Leu Leu Thr Asp Tyr Glu Ala Val Cys Gly Arg Arg 
305                 310                 315                 320 


Ala Arg Leu Glu Arg Glu Val Gln Gly Ala Phe Leu Arg Phe Met Ala 
                325                 330                 335     


Cys Leu Leu Lys Gly Tyr Arg Val Phe Leu Arg Pro Leu Thr Gln Ala 
            340                 345                 350         


Pro Ser Glu Gly Ala Arg Asp Val Asp Asn Leu Phe Phe Leu Gln Gly 
        355                 360                 365             


Phe Leu Lys Ser Arg Glu Arg Ser Ser His Lys Leu Tyr Ser Gln Leu 
    370                 375                 380                 


Leu His Thr Gln Met Phe Ser Gln Phe Ile Glu Glu Cys Ser Phe Gly 
385                 390                 395                 400 


Ser Ala Arg His Ala Ala Leu Glu Phe Phe Asp Ser Cys Val Glu Lys 
                405                 410                 415     


Val His Pro Glu Gln Glu Lys Pro Glu Pro Thr Pro Leu Val Glu Leu 
            420                 425                 430         


Glu Glu Leu Ser Gly Ser Glu Leu Thr Val Phe Ile Thr Pro Pro Glu 
        435                 440                 445             


Glu Pro Ala Leu Pro Glu Gly Ser Glu Ser Thr Pro Gln Tyr Cys Tyr 
    450                 455                 460                 


Asp Gly Phe Pro Glu Leu Arg Ala Glu Leu Phe Glu Ser Leu Gln Glu 
465                 470                 475                 480 


Gln Pro Gly Ala Leu Pro Val Pro Gly Pro Ser Arg Ser Ala Pro Ser 
                485                 490                 495     


Ser Pro Ala Pro Arg Arg Thr Lys Gln Glu Met Lys Val Ala Gln Arg 
            500                 505                 510         


Met Ala Gln Lys Ser Ala Ala Val Pro Glu Leu Trp Ala Arg Cys Leu 
        515                 520                 525             


Leu Gly His Cys Tyr Gly Leu Trp Phe Leu Cys Leu Pro Ala Tyr Val 
    530                 535                 540                 


Arg Ser Ala Pro Ser Arg Val Gln Ala Leu His Thr Ala Tyr His Val 
545                 550                 555                 560 


Leu Arg Gln Met Glu Ser Gly Lys Val Val Leu Pro Asp Glu Val Cys 
                565                 570                 575     


Tyr Arg Val Leu Met Gln Leu Cys Ser His Tyr Gly Gln Pro Val Leu 
            580                 585                 590         


Ser Val Arg Val Met Leu Glu Met Arg Gln Ala Gly Ile Val Pro Asn 
        595                 600                 605             


Thr Ile Thr Tyr Gly Tyr Tyr Asn Lys Ala Val Leu Glu Ser Lys Trp 
    610                 615                 620                 


Pro Ser Gly Thr Pro Gly Gly Arg Leu Arg Trp Ala Lys Leu Arg Asn 
625                 630                 635                 640 


Val Val Leu Gly Ala Ala Gln Phe Arg Gln Pro Leu Arg Glu Arg Gln 
                645                 650                 655     


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Glu 
            660                 665                 670         


Gln Val Ser Ala His Gln Glu Ala Gly Ser Ser Gln Ala Glu Pro Tyr 
        675                 680                 685             


Leu Glu Arg Pro Ser Pro Thr Arg Pro Leu Gln Arg Gln Thr Thr Trp 
    690                 695                 700                 


Ala Gly Arg Ser Leu Arg Asp Pro Ala Ser Pro Pro Gly Arg Leu Val 
705                 710                 715                 720 


Lys Ser Gly Ser Leu Gly Ser Ala Arg Gly Ala Gln Pro Thr Val Glu 
                725                 730                 735     


Ala Gly Val Ala His Met Ile Glu Ala Leu Gly Val Leu Glu Pro Arg 
            740                 745                 750         


Gly Ser Pro Val Pro Trp His Asp Gly Ser Leu Ser Asp Leu Ser Leu 
        755                 760                 765             


Thr Gly Glu Glu Pro Leu Pro Gly Gly Ser Pro Gly Gly Ser Gly Ser 
    770                 775                 780                 


Ala Leu Ser Ala Gln Ser Thr Glu Ala Leu Glu Gly Leu Ser Gly Arg 
785                 790                 795                 800 


Gly Pro Lys Ala Gly Gly Arg Gln Asp Glu Ala Gly Thr Pro Arg Arg 
                805                 810                 815     


Gly Leu Gly Ala Arg Leu Gln Gln Leu Leu Thr Pro Ser Arg His Ser 
            820                 825                 830         


Pro Ala Ser Arg Ile Pro Pro Pro Glu Leu Pro Pro Asp Leu Pro Pro 
        835                 840                 845             


Pro Ala Arg Arg Ser Pro Met Asp Ser Leu Leu His Pro Arg Glu Arg 
    850                 855                 860                 


Pro Gly Ser Thr Ala Ser Glu Ser Ser Ala Ser Leu Gly Ser Glu Trp 
865                 870                 875                 880 


Asp Leu Ser Glu Ser Ser Leu Ser Asn Leu Ser Leu Arg Arg Ser Ser 
                885                 890                 895     


Glu Arg Leu Ser Asp Thr Pro Gly Ser Phe Gln Ser Pro Ser Leu Glu 
            900                 905                 910         


Ile Leu Leu Ser Ser Cys Ser Leu Cys Arg Ala Cys Asp Ser Leu Val 
        915                 920                 925             


Tyr Asp Glu Glu Ile Met Ala Gly Trp Ala Pro Asp Asp Ser Asn Leu 
    930                 935                 940                 


Asn Thr Thr Cys Pro Phe Cys Ala Cys Pro Phe Val Pro Leu Leu Ser 
945                 950                 955                 960 


Val Gln Thr Leu Asp Ser Arg Pro Ser Val Pro Ser Pro Lys Ser Ala 
                965                 970                 975     


Gly Ala Ser Gly Ser Lys Asp Ala Pro Val Pro Gly Gly Pro Gly Pro 
            980                 985                 990         


Val Leu Ser Asp Arg Arg Leu Cys  Leu Ala Leu Asp Glu  Pro Gln Leu 
        995                 1000                 1005             


Cys Asn  Gly His Met Gly Val  Arg Ala Gly Pro Lys  Gly His Glu 
    1010                 1015                 1020             


Glu Arg  Glu Cys Cys Pro Val  Trp Gly Leu Trp Gly  Ala Arg Glu 
    1025                 1030                 1035             


Arg Trp  Ala His Leu Leu Pro  Leu Arg Ala Arg Gly  Ile Pro Lys 
    1040                 1045                 1050             


Ala Val  Gly Cys Gly Gly Ser  Val Gly Gly Lys Ala  Leu Gly Met 
    1055                 1060                 1065             


Tyr Met  Pro Ser Thr Ala Leu  Pro Leu Cys Ala 
    1070                 1075                 

<210>  768
<211>  457
<212>  DNA
<213>  Homo sapiens

<400>  768
ctgcctatgt gcggtcggca ccctcccgag tgcaggcact gcacacagcc taccatgtgc     60

tgcgccagat ggagagcggc aaggtggtgc tccctgatga ggtgtgttac cgggtactga    120

tgcagctctg ctcacactat gggcagcctg tgctgtctgt gcgggtcatg ctggagatgc    180

gtcaggcagg cattgtgccc aacaccatca cctatggcta ctacaataag gtacctactt    240

tggggtgagg ggtgggatgg cagctgtgcc agggtgtgtg aggggaggct gctgctgctc    300

ccctcgctcc ttggagattg ggctggtact gtttgcctag gtcctggaac cactgtcatc    360

cacattgcac tcctgtggtg ccttagcacc tacagtttct cagacgaggc tgctttgatt    420

cccactcatg acagccctgc ctacaactaa tagtgtc                             457


<210>  769
<211>  59
<212>  PRT
<213>  Homo sapiens

<400>  769


Met Glu Ser Gly Lys Val Val Leu Pro Asp Glu Val Cys Tyr Arg Val 
1               5                   10                  15      


Leu Met Gln Leu Cys Ser His Tyr Gly Gln Pro Val Leu Ser Val Arg 
            20                  25                  30          


Val Met Leu Glu Met Arg Gln Ala Gly Ile Val Pro Asn Thr Ile Thr 
        35                  40                  45              


Tyr Gly Tyr Tyr Asn Lys Val Pro Thr Leu Gly 
    50                  55                  

<210>  770
<211>  1426
<212>  DNA
<213>  Homo sapiens

<400>  770
cagacctgct caccagcgtc tgtgaggccc tcgtctcggt gagtgccgcc ccgcctggcc     60

catcttcccc agaaccatgg ttctttctgg tgcccctatc cctgcctgga ctcttccctt    120

ttccttcctt gtggaggatc ctcagcccct ttccctgggc acagcctgca ggaacacata    180

gcttccatca ggagctcttc tctagagcct acttccaaca gcctctctca acaggcacca    240

actccccaag gccaatgccc tctctttctc tctcctgtgc ctcccactgc tgcctcaacc    300

ccctgttcac tggttctcac tgcctggtgc ttcagatgat cttcccactg cactggcagt    360

gcccctacat tcctctgtgc ccgctggtgc tggcagatgt gctgagtgcc ccagtgccct    420

tcattgtggg tatccactcc agctactttg atctgcatga cccgcctgct gatgtcatct    480

gtgtagacct tgataccaac acgctcttcc agactgagga aaagaagctc ctctcccctc    540

ggaccctgcc ccgcagaccc tacaaggttc tgctggccac actgacaaac ctgtaccagc    600

agctggacca gagtgagaag cctgggtggg gagggaggct gggaactgtc attgccctca    660

aacctccagt ttgcagaggt ctgtggggag ctagacattt cttaaggagg tgagtgaagt    720

taggattgca tttggtggaa ctgagggaga ttccaattcc aactgaagct agaaggaagg    780

gcagacagta ttcctgaaca tgtgggaaat atcaagcttg aacctgttag ttgaaggtaa    840

tactttagtt gctactggtg caaggtctgc cagaggctgg aggtggagat ggaggcatga    900

gagcagagtt gagggtaaca ctatgggagc cagccctgac tcttaggctg ccctggcctc    960

cagcatacac tggacctgag gaggaagcat ccctggagtt cctactgaca gactacgagg   1020

cagtgtgtgg ccgcagggcc cggctggagc gcgaagtcca aggagccttc ctccgcttca   1080

tggcctgtct gctcaagggc taccgggtct tcctgcgccc actcacccag gccccctccg   1140

agggagctcg tgatgttgac aaccttttct tcctgcaggg tatagagggc ctgtctctgc   1200

ttggagatgt atcatgggag gaggtggcga ggggctgggc tctgtcagaa aggcggaggg   1260

gactgggagc cactccattg tttattcctt cactaggcaa atgtttttat gggcacccgc   1320

tttgagccat ttaactcttc tggtcttggg ggggaatcag ggtacaaaga tgaaaccagc   1380

tgtggtcctg ccctctggag ccccaggctt ggggtagcca cagtaa                  1426


<210>  771
<211>  152
<212>  PRT
<213>  Homo sapiens

<400>  771


Met Pro Ser Leu Ser Leu Ser Cys Ala Ser His Cys Cys Leu Asn Pro 
1               5                   10                  15      


Leu Phe Thr Gly Ser His Cys Leu Val Leu Gln Met Ile Phe Pro Leu 
            20                  25                  30          


His Trp Gln Cys Pro Tyr Ile Pro Leu Cys Pro Leu Val Leu Ala Asp 
        35                  40                  45              


Val Leu Ser Ala Pro Val Pro Phe Ile Val Gly Ile His Ser Ser Tyr 
    50                  55                  60                  


Phe Asp Leu His Asp Pro Pro Ala Asp Val Ile Cys Val Asp Leu Asp 
65                  70                  75                  80  


Thr Asn Thr Leu Phe Gln Thr Glu Glu Lys Lys Leu Leu Ser Pro Arg 
                85                  90                  95      


Thr Leu Pro Arg Arg Pro Tyr Lys Val Leu Leu Ala Thr Leu Thr Asn 
            100                 105                 110         


Leu Tyr Gln Gln Leu Asp Gln Ser Glu Lys Pro Gly Trp Gly Gly Arg 
        115                 120                 125             


Leu Gly Thr Val Ile Ala Leu Lys Pro Pro Val Cys Arg Gly Leu Trp 
    130                 135                 140                 


Gly Ala Arg His Phe Leu Arg Arg 
145                 150         

<210>  772
<211>  2156
<212>  DNA
<213>  Homo sapiens

<400>  772
atggcggagg agcggccccc ccggctggtg gattacttcg tggtagctgg gcttgcaggg     60

aacggagcac ccatccctga ggaaacgtgg gttcctgaac ccagtgggcc cctgcgccct    120

ccccggccag ctgagcccat cacagatgtg gcagtcatcg ctagggcact gggcgaggaa    180

gtgccccagg gctacacatg catccaggct tctgctgggg gccacccctt ggaactcagt    240

gctggacttc tgggtggaac tcaacccgtc atctgctacc gcaggggccg tgacaagccc    300

cccctcgttg agctgggggt gttgtatgag gggaaggaac gtcccaagcc tggcttccaa    360

gtgcttgaca cgacacccta cagccactca gcaaacctgg cccctccagg ccccgggcac    420

ccccgcacct acctcactta ccggcgggca gcagaggggg cagggctgca tgccctgggc    480

atcactgacc tctgcctggt gctgcccagt aagggcgagg gcactcctca tacttactgc    540

cggctgcccc gcaacctcaa ccctggcatg tggggcccag cagtgtacct gtgctataag    600

gtgggcctgg cgaaggccaa cacgctggtg tacgaggcag gtgagtggcc cctttatccc    660

tccaatcctg tgaccctaca tccctttgcc ctggtgcctc ttggcaggca ccttaagtgt    720

ccccagagtt tactttctct ttgctactcg ggccttctct gggatccctt ggttcatttc    780

ccttggagtc tgatggaccc tgctcctttt gggtaccccc aactatgctg ggggtgcaga    840

gctgctgggc cgctacccgg aggaggacaa tgaggcgttc ccgctgcccg agtcagtgcc    900

cgtcttctgc ctgcccatgg gggccactat cgagtgctgg cctgcccaga ccaagtaccc    960

cgtgcccgtc ttctccacct ttgtgctcac gggtgcagct ggtgataagg tgtatggtgc   1020

cgccctgcag ttctacgagg cgttcccaag ggccaggcta tcagagcgac aggcacgggc   1080

actgggcctg ctgagcgccg tggagcgggg tcgggcactg gggggcagag ctgtgcgcag   1140

ccggcgtgcc atcgctgtgc tgtcccgctg gcctgccttc cctgccttcc gcgccttcct   1200

caccttcctt taccgctact ccgtctcagg cccccaccgc ctacccttgg aagcgcacat   1260

ctcccacttc attcacaacg ttcccttccc ttccccacag agaccccgca tcctagtgca   1320

gatgtctccc tatgacaact tgctcctctg tcagcctgta tcctcacccc tgcccctcag   1380

gtatgtgatc agattgtggg gaggggagct ttaatgacca aggacatggt aggtgctggg   1440

caggtgggtg cagctgttga ggtttatgca ggctgggtcc aggtggtggc tgtgcctggc   1500

atctggggaa gggtccccag ggtatcctgg tgaccctttc cccacctcgg cattgcctgc   1560

agtggtgcca gcttcctgca gctgctgcag agcctgggcc ctgagctggc tatcacactg   1620

ctgctggctg tgctcacaga gcacaagctg ctagtccact cgctgcggcc agacctgctc   1680

accagcgtct gtgaggccct cgtctcggtg agtgccgccc cgcctggccc atcttcccca   1740

gaaccatggt tctttctggt gcccctatcc ctgcctggac tcttcccttt tccttccttg   1800

tggaggatcc tcagcccctt tccctgggca cagcctgcag gaacacatag cttccatcag   1860

gagctcttct ctagagccta cttccaacag cctctctcaa caggcaccaa ctccccaagg   1920

ccaatgccct ctctttctct ctcctgtgcc tcccactgct gcctcaaccc cctgttcact   1980

ggttctcact gcctggtgct tcagatgatc ttcccactgc actggcagtg cccctacatt   2040

cctctgtgcc cgctggtgct ggcagatgtg ctgagtgccc cagtgccctt cattgtgggt   2100

atccactcca gctactttga tctgcatgac ccgcctgctg atgtcatctg tgtaga       2156


<210>  773
<211>  290
<212>  PRT
<213>  Homo sapiens

<400>  773


Met Ala Glu Glu Arg Pro Pro Arg Leu Val Asp Tyr Phe Val Val Ala 
1               5                   10                  15      


Gly Leu Ala Gly Asn Gly Ala Pro Ile Pro Glu Glu Thr Trp Val Pro 
            20                  25                  30          


Glu Pro Ser Gly Pro Leu Arg Pro Pro Arg Pro Ala Glu Pro Ile Thr 
        35                  40                  45              


Asp Val Ala Val Ile Ala Arg Ala Leu Gly Glu Glu Val Pro Gln Gly 
    50                  55                  60                  


Tyr Thr Cys Ile Gln Ala Ser Ala Gly Gly His Pro Leu Glu Leu Ser 
65                  70                  75                  80  


Ala Gly Leu Leu Gly Gly Thr Gln Pro Val Ile Cys Tyr Arg Arg Gly 
                85                  90                  95      


Arg Asp Lys Pro Pro Leu Val Glu Leu Gly Val Leu Tyr Glu Gly Lys 
            100                 105                 110         


Glu Arg Pro Lys Pro Gly Phe Gln Val Leu Asp Thr Thr Pro Tyr Ser 
        115                 120                 125             


His Ser Ala Asn Leu Ala Pro Pro Gly Pro Gly His Pro Arg Thr Tyr 
    130                 135                 140                 


Leu Thr Tyr Arg Arg Ala Ala Glu Gly Ala Gly Leu His Ala Leu Gly 
145                 150                 155                 160 


Ile Thr Asp Leu Cys Leu Val Leu Pro Ser Lys Gly Glu Gly Thr Pro 
                165                 170                 175     


His Thr Tyr Cys Arg Leu Pro Arg Asn Leu Asn Pro Gly Met Trp Gly 
            180                 185                 190         


Pro Ala Val Tyr Leu Cys Tyr Lys Val Gly Leu Ala Lys Ala Asn Thr 
        195                 200                 205             


Leu Val Tyr Glu Ala Gly Glu Trp Pro Leu Tyr Pro Ser Asn Pro Val 
    210                 215                 220                 


Thr Leu His Pro Phe Ala Leu Val Pro Leu Gly Arg His Leu Lys Cys 
225                 230                 235                 240 


Pro Gln Ser Leu Leu Ser Leu Cys Tyr Ser Gly Leu Leu Trp Asp Pro 
                245                 250                 255     


Leu Val His Phe Pro Trp Ser Leu Met Asp Pro Ala Pro Phe Gly Tyr 
            260                 265                 270         


Pro Gln Leu Cys Trp Gly Cys Arg Ala Ala Gly Pro Leu Pro Gly Gly 
        275                 280                 285             


Gly Gln 
    290 

<210>  774
<211>  661
<212>  DNA
<213>  Homo sapiens

<400>  774
ctgatggacc ctgctccttt tgggtacccc caactatgct gggggtgcag agctgctggg     60

ccgctacccg gaggaggaca atgaggcgtt cccgctgccc gagtcagtgc ccgtcttctg    120

cctgcccatg ggggccacta tcgagtgctg gcctgcccag accaagtacc ccgtgcccgt    180

cttctccacc tttgtgctca cgggtgcagc tggtgataag gtgggtgtgt ggagtgtggc    240

aaggggtcca ggctatgcag ggcctgcctg actacccttc tgccccctgc caggtgtatg    300

gtgccgccct gcagttctac gaggcgttcc caagggccag gctatcagag cgacaggcac    360

gggcactggg cctgctgagc gccgtggagc ggggtcgggc actggggggc agagctgtgc    420

gcagccggcg tgccatcgct gtgctgtccc gctggcctgc cttccctgcc ttccgcgcct    480

tcctcacctt cctttaccgc tactccgtct caggccccca ccgcctaccc ttggaagcgc    540

acatctccca cttcattcac aacgttccct tcccttcccc acagagaccc cgcatcctag    600

tgcagatgtc tccctatgac aacttgctcc tctgtcagcc tgtatcctca cccctgcccc    660

t                                                                    661


<210>  775
<211>  207
<212>  PRT
<213>  Homo sapiens

<400>  775


Met Leu Gly Val Gln Ser Cys Trp Ala Ala Thr Arg Arg Arg Thr Met 
1               5                   10                  15      


Arg Arg Ser Arg Cys Pro Ser Gln Cys Pro Ser Ser Ala Cys Pro Trp 
            20                  25                  30          


Gly Pro Leu Ser Ser Ala Gly Leu Pro Arg Pro Ser Thr Pro Cys Pro 
        35                  40                  45              


Ser Ser Pro Pro Leu Cys Ser Arg Val Gln Leu Val Ile Arg Trp Val 
    50                  55                  60                  


Cys Gly Val Trp Gln Gly Val Gln Ala Met Gln Gly Leu Pro Asp Tyr 
65                  70                  75                  80  


Pro Ser Ala Pro Cys Gln Val Tyr Gly Ala Ala Leu Gln Phe Tyr Glu 
                85                  90                  95      


Ala Phe Pro Arg Ala Arg Leu Ser Glu Arg Gln Ala Arg Ala Leu Gly 
            100                 105                 110         


Leu Leu Ser Ala Val Glu Arg Gly Arg Ala Leu Gly Gly Arg Ala Val 
        115                 120                 125             


Arg Ser Arg Arg Ala Ile Ala Val Leu Ser Arg Trp Pro Ala Phe Pro 
    130                 135                 140                 


Ala Phe Arg Ala Phe Leu Thr Phe Leu Tyr Arg Tyr Ser Val Ser Gly 
145                 150                 155                 160 


Pro His Arg Leu Pro Leu Glu Ala His Ile Ser His Phe Ile His Asn 
                165                 170                 175     


Val Pro Phe Pro Ser Pro Gln Arg Pro Arg Ile Leu Val Gln Met Ser 
            180                 185                 190         


Pro Tyr Asp Asn Leu Leu Leu Cys Gln Pro Val Ser Ser Pro Leu 
        195                 200                 205         

<210>  776
<211>  749
<212>  DNA
<213>  Homo sapiens

<400>  776
ctgaggaaac gtgggttcct gaacccagtg ggcccctgcg ccctccccgg ccagctgagc     60

ccatcacaga tgtggcagtc atcgctaggg cactgggcga ggaagtgccc cagggctaca    120

catgcatcca ggcttctgct gggggccacc ccttggaact cagtgctgga cttctgggtg    180

gaactcaacc cgtcatctgc taccgcaggg gccgtgacaa gccccccctc gttgagctgg    240

gggtgttgta tgaggggaag gaacgtccca agcctggctt ccaagtgctt gacacgacac    300

cctacagcca ctcagcaaac ctggcccctc caggccccgg gcacccccgc acctacctca    360

cttaccggcg ggcagcagag ggggcagggc tgcatgccct gggcatcact gacctctgcc    420

tggtgctgcc cagtaagggc gagggcactc ctcatactta ctgccggctg ccccgcaacc    480

tcaaccctgg catgtggggc ccagcagtgt acctgtgcta taaggtgggc ctggcgaagg    540

ccaacacgct ggtgtacgag gcaggtgtat ggtgccgccc tgcagttcta cgaggcgttc    600

ccaagggcca ggctatcaga gcgacaggca cgggcactgg gcctgctgag cgccgtggag    660

cggggtcggg cactgggggg cagagctgtg cgcagccggc gtgccatcgc tgtgctgtcc    720

cgctggcctg ccttccctgc cttccgcgc                                      749


<210>  777
<211>  225
<212>  PRT
<213>  Homo sapiens

<400>  777


Met Trp Gln Ser Ser Leu Gly His Trp Ala Arg Lys Cys Pro Arg Ala 
1               5                   10                  15      


Thr His Ala Ser Arg Leu Leu Leu Gly Ala Thr Pro Trp Asn Ser Val 
            20                  25                  30          


Leu Asp Phe Trp Val Glu Leu Asn Pro Ser Ser Ala Thr Ala Gly Ala 
        35                  40                  45              


Val Thr Ser Pro Pro Ser Leu Ser Trp Gly Cys Cys Met Arg Gly Arg 
    50                  55                  60                  


Asn Val Pro Ser Leu Ala Ser Lys Cys Leu Thr Arg His Pro Thr Ala 
65                  70                  75                  80  


Thr Gln Gln Thr Trp Pro Leu Gln Ala Pro Gly Thr Pro Ala Pro Thr 
                85                  90                  95      


Ser Leu Thr Gly Gly Gln Gln Arg Gly Gln Gly Cys Met Pro Trp Ala 
            100                 105                 110         


Ser Leu Thr Ser Ala Trp Cys Cys Pro Val Arg Ala Arg Ala Leu Leu 
        115                 120                 125             


Ile Leu Thr Ala Gly Cys Pro Ala Thr Ser Thr Leu Ala Cys Gly Ala 
    130                 135                 140                 


Gln Gln Cys Thr Cys Ala Ile Arg Trp Ala Trp Arg Arg Pro Thr Arg 
145                 150                 155                 160 


Trp Cys Thr Arg Gln Val Tyr Gly Ala Ala Leu Gln Phe Tyr Glu Ala 
                165                 170                 175     


Phe Pro Arg Ala Arg Leu Ser Glu Arg Gln Ala Arg Ala Leu Gly Leu 
            180                 185                 190         


Leu Ser Ala Val Glu Arg Gly Arg Ala Leu Gly Gly Arg Ala Val Arg 
        195                 200                 205             


Ser Arg Arg Ala Ile Ala Val Leu Ser Arg Trp Pro Ala Phe Pro Ala 
    210                 215                 220                 


Phe 
225 

<210>  778
<211>  663
<212>  DNA
<213>  Homo sapiens

<400>  778
acccccatac ccatacagct ccccaagtct ggttctgcct gatcctgctg tggaggagtc     60

attccgcagt gaccggctcc aatgagggca cctcatcacc atccctcttc ttggccccat    120

cccccaccac cattcctttc ctcccttccc cctggcaggt agagactcta ctctctgtcc    180

ccagatcctc tttctagcat gaatgaagga tgccaagaat gagaaaaagc aaggggtttg    240

tccaggtggc ccctgaattc tgcgcaaggg atgggcctgg gggaactcaa gggagggcct    300

aaagcacttg taactttgaa ccgtctgtct ggaggtcaga gcctgttgga aagcaggggt    360

agaggggagc cctggaagca gggcttttcc ggatgcctag gggtgggcag tgccagcccc    420

tcctcaccac tcttcccctt gcagtggagg agagagccag agtggatact attttttatt    480

aaatatatta ttatatgtta ataaaaaaat catatcaaac ccttggtgtg gttagttatt    540

tggggcatgg ctggggatct agggagttat agggccatgg gtctttttat ctattaggct    600

ttttgcatct tcttagcacc actgtgcttt gtggaagggc cccacagcct cggaatttgt    660

acc                                                                  663


<210>  779
<211>  76
<212>  PRT
<213>  Homo sapiens

<400>  779


Met Gly Leu Gly Glu Leu Lys Gly Gly Pro Lys Ala Leu Val Thr Leu 
1               5                   10                  15      


Asn Arg Leu Ser Gly Gly Gln Ser Leu Leu Glu Ser Arg Gly Arg Gly 
            20                  25                  30          


Glu Pro Trp Lys Gln Gly Phe Ser Gly Cys Leu Gly Val Gly Ser Ala 
        35                  40                  45              


Ser Pro Ser Ser Pro Leu Phe Pro Leu Gln Trp Arg Arg Glu Pro Glu 
    50                  55                  60                  


Trp Ile Leu Phe Phe Ile Lys Tyr Ile Ile Ile Cys 
65                  70                  75      

<210>  780
<211>  1518
<212>  DNA
<213>  Homo sapiens

<400>  780
actgcccacc acctccctgg gccacccctc actcagtgct ccggctctct cctcctcctc     60

ttcctcctcc tccacttcat ctcctgtttt gggcgccccc tcttaccctg cttctacccc    120

tggggcctcc ccccaccacc gccgtgtgcc cctcagcccc ctgagtttgc tcgcgggccc    180

agccgacgcc agaaggtccc aacagcagct gcccaaacag ttttcgccaa caatgtcacc    240

caccttgtct tccatcactc agggcgtccc cctggatacc agtaaactgt ccactgacca    300

gcggttaccc ccatacccat acagctcccc aagtctggtt ctgcctaccc agccccacac    360

cccaaagtct ctacagcagc cagggctgcc ctctcagtct tgttcagtgc agtcctcagg    420

tgggcagccc ccaggcaggc agtctcatta tgggacaccg tacccacctg ggcccagtgg    480

gcatgggcaa cagtcttacc accggccaat gagtgacttc aacctgggga atctggagca    540

gttcagcatg gagagcccat cagccagcct ggtgctggat ccccctggct tttctgaagg    600

gcctggattt ttagggggtg aggggccaat gggtggcccc caggatcccc acaccttcaa    660

ccaccagaac ttgacccact gttcccgcca tggctcaggg cctaacatca tcctcacagg    720

ggactcctct ccaggtttct ctaaggagat tgcagcagcc ctggccggag tgcctggctt    780

tgaggtgtca gcagctggat tggagctagg gcttgggcta gaagatgagc tgcgcatgga    840

gccactgggc ctggaagggc taaacatgct gagtgacccc tgtgccctgc tgcctgatcc    900

tgctgtggag gagtcattcc gcagtgaccg gctccaatga gggcacctca tcaccatccc    960

tcttcttggc cccatccccc accaccattc ctttcctccc ttccccctgg caggtagaga   1020

ctctactctc tgtccccaga tcctctttct agcatgaatg aaggatgcca agaatgagaa   1080

aaagcaaggg gtttgtccag gtggcccctg aattctgcgc aagggatggg cctgggggaa   1140

ctcaagggag ggcctaaagc acttgtaact ttgaaccgtc tgtctggagg tcagagcctg   1200

ttggaaagca ggggtagagg ggagccctgg aagcagggct tttccggatg cctaggggtg   1260

ggcagtgcca gcccctcctc accactcttc cccttgcagt ggaggagaga gccagagtgg   1320

atactatttt ttattaaata tattattata tgttaataaa aaaatcatat caaacccttg   1380

gtgtggttag ttatttgggg catggctggg gatctaggga gttatagggc catgggtctt   1440

tttatctatt aggctttttg catcttctta gcaccactgt gctttgtgga agggccccac   1500

agcctcggaa tttgtacc                                                 1518


<210>  781
<211>  235
<212>  PRT
<213>  Homo sapiens

<400>  781


Met Ser Pro Thr Leu Ser Ser Ile Thr Gln Gly Val Pro Leu Asp Thr 
1               5                   10                  15      


Ser Lys Leu Ser Thr Asp Gln Arg Leu Pro Pro Tyr Pro Tyr Ser Ser 
            20                  25                  30          


Pro Ser Leu Val Leu Pro Thr Gln Pro His Thr Pro Lys Ser Leu Gln 
        35                  40                  45              


Gln Pro Gly Leu Pro Ser Gln Ser Cys Ser Val Gln Ser Ser Gly Gly 
    50                  55                  60                  


Gln Pro Pro Gly Arg Gln Ser His Tyr Gly Thr Pro Tyr Pro Pro Gly 
65                  70                  75                  80  


Pro Ser Gly His Gly Gln Gln Ser Tyr His Arg Pro Met Ser Asp Phe 
                85                  90                  95      


Asn Leu Gly Asn Leu Glu Gln Phe Ser Met Glu Ser Pro Ser Ala Ser 
            100                 105                 110         


Leu Val Leu Asp Pro Pro Gly Phe Ser Glu Gly Pro Gly Phe Leu Gly 
        115                 120                 125             


Gly Glu Gly Pro Met Gly Gly Pro Gln Asp Pro His Thr Phe Asn His 
    130                 135                 140                 


Gln Asn Leu Thr His Cys Ser Arg His Gly Ser Gly Pro Asn Ile Ile 
145                 150                 155                 160 


Leu Thr Gly Asp Ser Ser Pro Gly Phe Ser Lys Glu Ile Ala Ala Ala 
                165                 170                 175     


Leu Ala Gly Val Pro Gly Phe Glu Val Ser Ala Ala Gly Leu Glu Leu 
            180                 185                 190         


Gly Leu Gly Leu Glu Asp Glu Leu Arg Met Glu Pro Leu Gly Leu Glu 
        195                 200                 205             


Gly Leu Asn Met Leu Ser Asp Pro Cys Ala Leu Leu Pro Asp Pro Ala 
    210                 215                 220                 


Val Glu Glu Ser Phe Arg Ser Asp Arg Leu Gln 
225                 230                 235 

<210>  782
<211>  2395
<212>  DNA
<213>  Homo sapiens

<400>  782
gggccgaggc cgcggcggag gccgcggctg gtactgggag ggtggcaggg agggacgggg     60

aaggaagatg gcgacgtcgg gggcgaacgg gcctggttcg gccacggcct cggcttccaa    120

tccgcgcaaa tttagtgaga agattgcgct gcagaagcag cgtcaggccg aggagacggc    180

ggccttcgag gaggtgatga tggacatcgg ctccacccgg ttacaggccc aaaaactgcg    240

actggcatac acaaggagct ctcattatgg tgggtctctg cccaatgtta accagattgg    300

ctctggcctg gccgagttcc aggtgagtag accccagcca gggaggagtg gagtttctta    360

ggctgcttcc tctgctgact tctgtccttt ttggcagagc cccctccact cacctttgga    420

ttcatctcgg agcactcggc accatgggct ggtggaacgg gtgcagcgag atcctcgaag    480

aatggtgtcc ccacttcgcc gatacacccg ccacattgac agctctccct atagtcctgc    540

ctacttatct cctcccccag agtctagctg gcgaaggacg atggcctggg gcaatttccc    600

tgcagagaag gggcagttgt ttcgactacc atctgcactt aacaggacaa gctctgactc    660

tgcccttcat acaagtgtga tgaaccccag tccccaggat acctacccag gccccacacc    720

tcccagcatc ctgcccagcc gacgtggggg tattctggat ggtgaaatgg accccaaagt    780

acctgctatt gaggagaact tgctagatga caagcatttg ctgaagccat gggatgctaa    840

gaagctatcc tcatcctctt cccgacctcg gtcctgtgaa gtccctggaa ttaacatctt    900

tccatctcct gaccagcctg ccaatgtgcc tgtcctccca cctgccatga acacgggggg    960

ctccctacct gacctcacca acctgcactt tcccccacca ctgcccaccc ccctggaccc   1020

tgaagagaca gcctacccta gcctgagtgg gggcaacagt acctccaatt tgacccacac   1080

catgactcac ctgggcatca gcaggggcat gggcctgggc ccaggctatg atgcaccagg   1140

gcgtccccct ggataccagt aaactgtcca ctgaccagcg gttaccccca tacccataca   1200

gctccccaag tctggttctg cctacccagc cccacacccc aaagtctcta cagcagccag   1260

ggctgccctc tcagtcttgt tcagtgcagt cctcaggtgg gcagccccca ggcaggcagt   1320

ctcattatgg gacaccgtac ccacctgggc ccagtgggca tgggcaacag tcttaccacc   1380

ggccaatgag tgacttcaac ctggggaatc tggagcagtt cagcatggag agcccatcag   1440

ccagcctggt gctggatccc cctggctttt ctgaagggcc tggattttta gggggtgagg   1500

ggccaatggg tggcccccag gatccccaca ccttcaacca ccagaacttg acccactgtt   1560

cccgccatgg ctcagggcct aacatcatcc tcacagggga ctcctctcca ggtttctcta   1620

aggagattgc agcagccctg gccggagtgc ctggctttga ggtgtcagca gctggattgg   1680

agctagggct tgggctagaa gatgagctgc gcatggagcc actgggcctg gaagggctaa   1740

acatgctgag tgacccctgt gccctgctgc ctgatcctgc tgtggaggag tcattccgca   1800

gtgaccggct ccaatgaggg cacctcatca ccatccctct tcttggcccc atcccccacc   1860

accattcctt tcctcccttc cccctggcag gtagagactc tactctctgt ccccagatcc   1920

tctttctagc atgaatgaag gatgccaaga atgagaaaaa gcaaggggtt tgtccaggtg   1980

gcccctgaat tctgcgcaag ggatgggcct gggggaactc aagggagggc ctaaagcact   2040

tgtaactttg aaccgtctgt ctggaggtca gagcctgttg gaaagcaggg gtagagggga   2100

gccctggaag cagggctttt ccggatgcct aggggtgggc agtgccagcc cctcctcacc   2160

actcttcccc ttgcagtgga ggagagagcc agagtggata ctatttttta ttaaatatat   2220

tattatatgt taataaaaaa atcatatcaa acccttggtg tggttagtta tttggggcat   2280

ggctggggat ctagggagtt atagggccat gggtcttttt atctattagg ctttttgcat   2340

cttcttagca ccactgtgct ttgtggaagg gccccacagc ctcggaattt gtacc        2395


<210>  783
<211>  229
<212>  PRT
<213>  Homo sapiens

<400>  783


Met Met His Gln Gly Val Pro Leu Asp Thr Ser Lys Leu Ser Thr Asp 
1               5                   10                  15      


Gln Arg Leu Pro Pro Tyr Pro Tyr Ser Ser Pro Ser Leu Val Leu Pro 
            20                  25                  30          


Thr Gln Pro His Thr Pro Lys Ser Leu Gln Gln Pro Gly Leu Pro Ser 
        35                  40                  45              


Gln Ser Cys Ser Val Gln Ser Ser Gly Gly Gln Pro Pro Gly Arg Gln 
    50                  55                  60                  


Ser His Tyr Gly Thr Pro Tyr Pro Pro Gly Pro Ser Gly His Gly Gln 
65                  70                  75                  80  


Gln Ser Tyr His Arg Pro Met Ser Asp Phe Asn Leu Gly Asn Leu Glu 
                85                  90                  95      


Gln Phe Ser Met Glu Ser Pro Ser Ala Ser Leu Val Leu Asp Pro Pro 
            100                 105                 110         


Gly Phe Ser Glu Gly Pro Gly Phe Leu Gly Gly Glu Gly Pro Met Gly 
        115                 120                 125             


Gly Pro Gln Asp Pro His Thr Phe Asn His Gln Asn Leu Thr His Cys 
    130                 135                 140                 


Ser Arg His Gly Ser Gly Pro Asn Ile Ile Leu Thr Gly Asp Ser Ser 
145                 150                 155                 160 


Pro Gly Phe Ser Lys Glu Ile Ala Ala Ala Leu Ala Gly Val Pro Gly 
                165                 170                 175     


Phe Glu Val Ser Ala Ala Gly Leu Glu Leu Gly Leu Gly Leu Glu Asp 
            180                 185                 190         


Glu Leu Arg Met Glu Pro Leu Gly Leu Glu Gly Leu Asn Met Leu Ser 
        195                 200                 205             


Asp Pro Cys Ala Leu Leu Pro Asp Pro Ala Val Glu Glu Ser Phe Arg 
    210                 215                 220                 


Ser Asp Arg Leu Gln 
225                 

<210>  784
<211>  2819
<212>  DNA
<213>  Homo sapiens

<400>  784
cccggcggcc cccgcgcgca acaggtcagg gctaggctgg ggccgggttc gcggtgctcg     60

ctgaggcggc ggtggctacg gctggaggag ccgggccgag gccgcggcgg aggccgcggc    120

tggtactggg agggtggcag ggagggacgg ggaaggaaga tggcgacgtc gggggcgaac    180

gggcctggtt cggccacggc ctcggcttcc aatccgcgca aatttagtga gaagattgcg    240

ctgcagaagc agcgtcaggc cgaggagacg gcggccttcg aggaggtgat gatggacatc    300

ggctccaccc ggttacaggc ccaaaaactg cgactggcat acacaaggag ctctcattat    360

ggtgggtctc tgcccaatgt taaccagatt ggctctggcc tggccgagtt ccagagcccc    420

ctccactcac ctttggattc atctcggagc actcggcacc atgggctggt ggaacgggtg    480

cagcgagatc ctcgaagaat ggtgtcccca cttcgccgat acacccgcca cattgacagc    540

tctccctata gtcctgccta cttatctcct cccccagagt ctagctggcg aaggacgatg    600

gcctggggca atttccctgc agagaagggg cagttgtttc gactaccatc tgcacttaac    660

aggacaagct ctgactctgc ccttcataca agtgtgatga accccagtcc ccaggatacc    720

tacccaggcc ccacacctcc cagcatcctg cccagccgac gtgggggtat tctggatggt    780

gaaatggacc ccaaagtacc tgctattgag gagaacttgc tagatgacaa gcatttgctg    840

aagccatggg atgctaagaa gctatcctca tcctcttccc gacctcggtc ctgtgaagtc    900

cctggaatta acatctttcc atctcctgac cagcctgcca atgtgcctgt cctcccacct    960

gccatgaaca cggggggctc cctacctgac ctcaccaacc tgcactttcc cccaccactg   1020

cccacccccc tggaccctga agagacagcc taccctagcc tgagtggggg caacagtacc   1080

tccaatttga cccacaccat gactcacctg ggcatcagca ggggcatggg cctgggccca   1140

ggctatgatg caccaggact tcattcacct ctcagccacc catccctgca gtcctcccta   1200

agcaatccca acctccaggc ttccctgagc agtcctcagc cccagcttca gggctcccac   1260

agccacccct ctctgcctgc ctcctccttg gcccgccatg tactgcccac cacctccctg   1320

ggccacccct cactcagtgc tccggctctc tcctcctcct cttcctcctc ctccacttca   1380

tctcctgttt tgggcgcccc ctcttaccct gcttctaccc ctggggcctc cccccaccac   1440

cgccgtgtgc ccctcagccc cctgagtttg ctcgcgggcc cagccgacgc cagaaggtcc   1500

caacagcagc tgcccaaaca gttttcgcca acaatgtcac ccaccttgtc ttccatcact   1560

cagggcgtcc ccctggatac cagtaaactg tccactgacc agcggttacc cccataccca   1620

tacagctccc caagtctggt tctgcctacc cagccccaca ccccaaagtc tctacagcag   1680

ccagggctgc cctctcagtc ttgttcagtg cagtcctcag gtgggcagcc cccaggcagg   1740

cagtctcatt atgggacacc gtacccacct gggcccagtg ggcatgggca acagtcttac   1800

caccggccaa tgagtgactt caacctgggg aatctggagc agttcagcat ggagagccca   1860

tcagccagcc tggtgctgga tccccctggc ttttctgaag ggcctggatt tttagggggt   1920

gaggggccaa tgggtggccc ccaggatccc cacaccttca accaccagaa cttgacccac   1980

tgttcccgcc atggctcagg gcctaacatc atcctcacag gggactcctc tccaggtttc   2040

tctaaggaga ttgcagcagc cctggccgga gtgcctggct ttgaggtgtc agcagctgga   2100

ttggagctag ggcttgggct agaagatgag ctgcgcatgg agccactggg cctggaaggg   2160

ctaaacatgc tgagtgaccc ctgtgccctg ctgcctgatc ctgctgtgga ggagtcattc   2220

cgcagtgacc ggctccaatg agggcacctc atcaccatcc ctcttcttgg ccccatcccc   2280

caccaccatt cctttcctcc cttccccctg gcaggtagag actctactct ctgtccccag   2340

atcctctttc tagcatgaat gaaggatgcc aagaatgaga aaaagcaagg ggtttgtcca   2400

ggtggcccct gaattctgcg caagggatgg gcctggggga actcaaggga gggcctaaag   2460

cacttgtaac tttgaaccgt ctgtctggag gtcagagcct gttggaaagc aggggtagag   2520

gggagccctg gaagcagggc ttttccggat gcctaggggt gggcagtgcc agcccctcct   2580

caccactctt ccccttgcag tggaggagag agccagagtg gatactattt tttattaaat   2640

atattattat atgttaataa aaaaatcata tcaaaccctt ggtgtggtta gttatttggg   2700

gcatggctgg ggatctaggg agttataggg ccatgggtct ttttatctat taggcttttt   2760

gcatcttctt agcaccactg tgctttgtgg aagggcccca cagcctcgga atttgtacc    2819


<210>  785
<211>  693
<212>  PRT
<213>  Homo sapiens

<400>  785


Met Ala Thr Ser Gly Ala Asn Gly Pro Gly Ser Ala Thr Ala Ser Ala 
1               5                   10                  15      


Ser Asn Pro Arg Lys Phe Ser Glu Lys Ile Ala Leu Gln Lys Gln Arg 
            20                  25                  30          


Gln Ala Glu Glu Thr Ala Ala Phe Glu Glu Val Met Met Asp Ile Gly 
        35                  40                  45              


Ser Thr Arg Leu Gln Ala Gln Lys Leu Arg Leu Ala Tyr Thr Arg Ser 
    50                  55                  60                  


Ser His Tyr Gly Gly Ser Leu Pro Asn Val Asn Gln Ile Gly Ser Gly 
65                  70                  75                  80  


Leu Ala Glu Phe Gln Ser Pro Leu His Ser Pro Leu Asp Ser Ser Arg 
                85                  90                  95      


Ser Thr Arg His His Gly Leu Val Glu Arg Val Gln Arg Asp Pro Arg 
            100                 105                 110         


Arg Met Val Ser Pro Leu Arg Arg Tyr Thr Arg His Ile Asp Ser Ser 
        115                 120                 125             


Pro Tyr Ser Pro Ala Tyr Leu Ser Pro Pro Pro Glu Ser Ser Trp Arg 
    130                 135                 140                 


Arg Thr Met Ala Trp Gly Asn Phe Pro Ala Glu Lys Gly Gln Leu Phe 
145                 150                 155                 160 


Arg Leu Pro Ser Ala Leu Asn Arg Thr Ser Ser Asp Ser Ala Leu His 
                165                 170                 175     


Thr Ser Val Met Asn Pro Ser Pro Gln Asp Thr Tyr Pro Gly Pro Thr 
            180                 185                 190         


Pro Pro Ser Ile Leu Pro Ser Arg Arg Gly Gly Ile Leu Asp Gly Glu 
        195                 200                 205             


Met Asp Pro Lys Val Pro Ala Ile Glu Glu Asn Leu Leu Asp Asp Lys 
    210                 215                 220                 


His Leu Leu Lys Pro Trp Asp Ala Lys Lys Leu Ser Ser Ser Ser Ser 
225                 230                 235                 240 


Arg Pro Arg Ser Cys Glu Val Pro Gly Ile Asn Ile Phe Pro Ser Pro 
                245                 250                 255     


Asp Gln Pro Ala Asn Val Pro Val Leu Pro Pro Ala Met Asn Thr Gly 
            260                 265                 270         


Gly Ser Leu Pro Asp Leu Thr Asn Leu His Phe Pro Pro Pro Leu Pro 
        275                 280                 285             


Thr Pro Leu Asp Pro Glu Glu Thr Ala Tyr Pro Ser Leu Ser Gly Gly 
    290                 295                 300                 


Asn Ser Thr Ser Asn Leu Thr His Thr Met Thr His Leu Gly Ile Ser 
305                 310                 315                 320 


Arg Gly Met Gly Leu Gly Pro Gly Tyr Asp Ala Pro Gly Leu His Ser 
                325                 330                 335     


Pro Leu Ser His Pro Ser Leu Gln Ser Ser Leu Ser Asn Pro Asn Leu 
            340                 345                 350         


Gln Ala Ser Leu Ser Ser Pro Gln Pro Gln Leu Gln Gly Ser His Ser 
        355                 360                 365             


His Pro Ser Leu Pro Ala Ser Ser Leu Ala Arg His Val Leu Pro Thr 
    370                 375                 380                 


Thr Ser Leu Gly His Pro Ser Leu Ser Ala Pro Ala Leu Ser Ser Ser 
385                 390                 395                 400 


Ser Ser Ser Ser Ser Thr Ser Ser Pro Val Leu Gly Ala Pro Ser Tyr 
                405                 410                 415     


Pro Ala Ser Thr Pro Gly Ala Ser Pro His His Arg Arg Val Pro Leu 
            420                 425                 430         


Ser Pro Leu Ser Leu Leu Ala Gly Pro Ala Asp Ala Arg Arg Ser Gln 
        435                 440                 445             


Gln Gln Leu Pro Lys Gln Phe Ser Pro Thr Met Ser Pro Thr Leu Ser 
    450                 455                 460                 


Ser Ile Thr Gln Gly Val Pro Leu Asp Thr Ser Lys Leu Ser Thr Asp 
465                 470                 475                 480 


Gln Arg Leu Pro Pro Tyr Pro Tyr Ser Ser Pro Ser Leu Val Leu Pro 
                485                 490                 495     


Thr Gln Pro His Thr Pro Lys Ser Leu Gln Gln Pro Gly Leu Pro Ser 
            500                 505                 510         


Gln Ser Cys Ser Val Gln Ser Ser Gly Gly Gln Pro Pro Gly Arg Gln 
        515                 520                 525             


Ser His Tyr Gly Thr Pro Tyr Pro Pro Gly Pro Ser Gly His Gly Gln 
    530                 535                 540                 


Gln Ser Tyr His Arg Pro Met Ser Asp Phe Asn Leu Gly Asn Leu Glu 
545                 550                 555                 560 


Gln Phe Ser Met Glu Ser Pro Ser Ala Ser Leu Val Leu Asp Pro Pro 
                565                 570                 575     


Gly Phe Ser Glu Gly Pro Gly Phe Leu Gly Gly Glu Gly Pro Met Gly 
            580                 585                 590         


Gly Pro Gln Asp Pro His Thr Phe Asn His Gln Asn Leu Thr His Cys 
        595                 600                 605             


Ser Arg His Gly Ser Gly Pro Asn Ile Ile Leu Thr Gly Asp Ser Ser 
    610                 615                 620                 


Pro Gly Phe Ser Lys Glu Ile Ala Ala Ala Leu Ala Gly Val Pro Gly 
625                 630                 635                 640 


Phe Glu Val Ser Ala Ala Gly Leu Glu Leu Gly Leu Gly Leu Glu Asp 
                645                 650                 655     


Glu Leu Arg Met Glu Pro Leu Gly Leu Glu Gly Leu Asn Met Leu Ser 
            660                 665                 670         


Asp Pro Cys Ala Leu Leu Pro Asp Pro Ala Val Glu Glu Ser Phe Arg 
        675                 680                 685             


Ser Asp Arg Leu Gln 
    690             

<210>  786
<211>  522
<212>  DNA
<213>  Homo sapiens

<400>  786
acccccatac ccatacagct ccccaagtct ggttctgcct gatcctgctg tggaggagtc     60

attccgcagt gaccggctcc aatgagggca cctcatcacc atccctcttc ttggccccat    120

cccccaccac cattcctttc ctcccttccc cctggcaggt agagactcta ctctctgtcc    180

ccagatcctc tttctagcat gaatgaagga tgccaagaat gagaaaaagc aaggggtttg    240

tccaggtggc ccctgaattc tgcgcaaggg atgggcctgg gggaactcaa gggagggcct    300

aaagcacttg taactttgaa ccgtctgtct ggaggtcaga gcctgttgga aagcaggggt    360

agaggggagc cctggaagca gggcttttcc ggatgcctag gggtgggcag tgccagcccc    420

tcctcaccac tcttcccctt gcagtggagg agagagccag agtggatact attttttatt    480

aaatatatta ttatatgtta ataaaaaaat catatcaaac cc                       522


<210>  787
<211>  76
<212>  PRT
<213>  Homo sapiens

<400>  787


Met Gly Leu Gly Glu Leu Lys Gly Gly Pro Lys Ala Leu Val Thr Leu 
1               5                   10                  15      


Asn Arg Leu Ser Gly Gly Gln Ser Leu Leu Glu Ser Arg Gly Arg Gly 
            20                  25                  30          


Glu Pro Trp Lys Gln Gly Phe Ser Gly Cys Leu Gly Val Gly Ser Ala 
        35                  40                  45              


Ser Pro Ser Ser Pro Leu Phe Pro Leu Gln Trp Arg Arg Glu Pro Glu 
    50                  55                  60                  


Trp Ile Leu Phe Phe Ile Lys Tyr Ile Ile Ile Cys 
65                  70                  75      

<210>  788
<211>  2254
<212>  DNA
<213>  Homo sapiens

<400>  788
gggccgaggc cgcggcggag gccgcggctg gtactgggag ggtggcaggg agggacgggg     60

aaggaagatg gcgacgtcgg gggcgaacgg gcctggttcg gccacggcct cggcttccaa    120

tccgcgcaaa tttagtgaga agattgcgct gcagaagcag cgtcaggccg aggagacggc    180

ggccttcgag gaggtgatga tggacatcgg ctccacccgg ttacaggccc aaaaactgcg    240

actggcatac acaaggagct ctcattatgg tgggtctctg cccaatgtta accagattgg    300

ctctggcctg gccgagttcc aggtgagtag accccagcca gggaggagtg gagtttctta    360

ggctgcttcc tctgctgact tctgtccttt ttggcagagc cccctccact cacctttgga    420

ttcatctcgg agcactcggc accatgggct ggtggaacgg gtgcagcgag atcctcgaag    480

aatggtgtcc ccacttcgcc gatacacccg ccacattgac agctctccct atagtcctgc    540

ctacttatct cctcccccag agtctagctg gcgaaggacg atggcctggg gcaatttccc    600

tgcagagaag gggcagttgt ttcgactacc atctgcactt aacaggacaa gctctgactc    660

tgcccttcat acaagtgtga tgaaccccag tccccaggat acctacccag gccccacacc    720

tcccagcatc ctgcccagcc gacgtggggg tattctggat ggtgaaatgg accccaaagt    780

acctgctatt gaggagaact tgctagatga caagcatttg ctgaagccat gggatgctaa    840

gaagctatcc tcatcctctt cccgacctcg gtcctgtgaa gtccctggaa ttaacatctt    900

tccatctcct gaccagcctg ccaatgtgcc tgtcctccca cctgccatga acacgggggg    960

ctccctacct gacctcacca acctgcactt tcccccacca ctgcccaccc ccctggaccc   1020

tgaagagaca gcctacccta gcctgagtgg gggcaacagt acctccaatt tgacccacac   1080

catgactcac ctgggcatca gcaggggcat gggcctgggc ccaggctatg atgcaccagg   1140

gcgtccccct ggataccagt aaactgtcca ctgaccagcg gttaccccca tacccataca   1200

gctccccaag tctggttctg cctacccagc cccacacccc aaagtctcta cagcagccag   1260

ggctgccctc tcagtcttgt tcagtgcagt cctcaggtgg gcagccccca ggcaggcagt   1320

ctcattatgg gacaccgtac ccacctgggc ccagtgggca tgggcaacag tcttaccacc   1380

ggccaatgag tgacttcaac ctggggaatc tggagcagtt cagcatggag agcccatcag   1440

ccagcctggt gctggatccc cctggctttt ctgaagggcc tggattttta gggggtgagg   1500

ggccaatggg tggcccccag gatccccaca ccttcaacca ccagaacttg acccactgtt   1560

cccgccatgg ctcagggcct aacatcatcc tcacagggga ctcctctcca ggtttctcta   1620

aggagattgc agcagccctg gccggagtgc ctggctttga ggtgtcagca gctggattgg   1680

agctagggct tgggctagaa gatgagctgc gcatggagcc actgggcctg gaagggctaa   1740

acatgctgag tgacccctgt gccctgctgc ctgatcctgc tgtggaggag tcattccgca   1800

gtgaccggct ccaatgaggg cacctcatca ccatccctct tcttggcccc atcccccacc   1860

accattcctt tcctcccttc cccctggcag gtagagactc tactctctgt ccccagatcc   1920

tctttctagc atgaatgaag gatgccaaga atgagaaaaa gcaaggggtt tgtccaggtg   1980

gcccctgaat tctgcgcaag ggatgggcct gggggaactc aagggagggc ctaaagcact   2040

tgtaactttg aaccgtctgt ctggaggtca gagcctgttg gaaagcaggg gtagagggga   2100

gccctggaag cagggctttt ccggatgcct aggggtgggc agtgccagcc cctcctcacc   2160

actcttcccc ttgcagtgga ggagagagcc agagtggata ctatttttta ttaaatatat   2220

tattatatgt taataaaaaa atcatatcaa accc                               2254


<210>  789
<211>  229
<212>  PRT
<213>  Homo sapiens

<400>  789


Met Met His Gln Gly Val Pro Leu Asp Thr Ser Lys Leu Ser Thr Asp 
1               5                   10                  15      


Gln Arg Leu Pro Pro Tyr Pro Tyr Ser Ser Pro Ser Leu Val Leu Pro 
            20                  25                  30          


Thr Gln Pro His Thr Pro Lys Ser Leu Gln Gln Pro Gly Leu Pro Ser 
        35                  40                  45              


Gln Ser Cys Ser Val Gln Ser Ser Gly Gly Gln Pro Pro Gly Arg Gln 
    50                  55                  60                  


Ser His Tyr Gly Thr Pro Tyr Pro Pro Gly Pro Ser Gly His Gly Gln 
65                  70                  75                  80  


Gln Ser Tyr His Arg Pro Met Ser Asp Phe Asn Leu Gly Asn Leu Glu 
                85                  90                  95      


Gln Phe Ser Met Glu Ser Pro Ser Ala Ser Leu Val Leu Asp Pro Pro 
            100                 105                 110         


Gly Phe Ser Glu Gly Pro Gly Phe Leu Gly Gly Glu Gly Pro Met Gly 
        115                 120                 125             


Gly Pro Gln Asp Pro His Thr Phe Asn His Gln Asn Leu Thr His Cys 
    130                 135                 140                 


Ser Arg His Gly Ser Gly Pro Asn Ile Ile Leu Thr Gly Asp Ser Ser 
145                 150                 155                 160 


Pro Gly Phe Ser Lys Glu Ile Ala Ala Ala Leu Ala Gly Val Pro Gly 
                165                 170                 175     


Phe Glu Val Ser Ala Ala Gly Leu Glu Leu Gly Leu Gly Leu Glu Asp 
            180                 185                 190         


Glu Leu Arg Met Glu Pro Leu Gly Leu Glu Gly Leu Asn Met Leu Ser 
        195                 200                 205             


Asp Pro Cys Ala Leu Leu Pro Asp Pro Ala Val Glu Glu Ser Phe Arg 
    210                 215                 220                 


Ser Asp Arg Leu Gln 
225                 

<210>  790
<211>  1638
<212>  DNA
<213>  Homo sapiens

<400>  790
gctggaggag ccgggccgag gccgcggcgg aggccgcggc tggtactggg agggtggcag     60

ggagggacgg ggaaggaaga tggcgacgtc gggggcgaac gggcctggtt cggccacggc    120

ctcggcttcc aatccgcgca aatttagtga gaagattgcg ctgcagaagc agcgtcaggc    180

ttccctgagc agtcctcagc cccagcttca gggctcccac agccacccct ctctgcctgc    240

ctcctccttg gcccgccatg tactgcccac cacctccctg ggccacccct cactcagtgc    300

tccggctctc tcctcctcct cttcctcctc ctccacttca tctcctgttt tgggcgcccc    360

ctcttaccct gcttctaccc ctggggcctc cccccaccac cgccgtgtgc ccctcagccc    420

cctgagtttg ctcgcgggcc cagccgacgc cagaaggtcc caacagcagc tgcccaaaca    480

gttttcgcca acaatgtcac ccaccttgtc ttccatcact cagggcgtcc ccctggatac    540

cagtaaactg tccactgacc agcggttacc cccataccca tacagctccc caagtctggt    600

tctgcctacc cagccccaca ccccaaagtc tctacagcag ccagggctgc cctctcagtc    660

ttgttcagtg cagtcctcag gtgggcagcc cccaggcagg cagtctcatt atgggacacc    720

gtacccacct gggcccagtg ggcatgggca acagtcttac caccggccaa tgagtgactt    780

caacctgggg aatctggagc agttcagcat ggagagccca tcagccagcc tggtgctgga    840

tccccctggc ttttctgaag ggcctggatt tttagggggt gaggggccaa tgggtggccc    900

ccaggatccc cacaccttca accaccagaa cttgacccac tgttcccgcc atggctcagg    960

gcctaacatc atcctcacag gggactcctc tccaggtttc tctaaggaga ttgcagcagc   1020

cctggccgga gtgcctggct ttgaggtgtc agcagctgga ttggagctag ggcttgggct   1080

agaagatgag ctgcgcatgg agccactggg cctggaaggg ctaaacatgc tgagtgaccc   1140

ctgtgccctg ctgcctgatc ctgctgtgga ggagtcattc cgcagtgacc ggctccaatg   1200

agggcacctc atcaccatcc ctcttcttgg ccccatcccc caccaccatt cctttcctcc   1260

cttccccctg gcaggtagag actctactct ctgtccccag atcctctttc tagcatgaat   1320

gaaggatgcc aagaatgaga aaaagcaagg ggtttgtcca ggtggcccct gaattctgcg   1380

caagggatgg gcctggggga actcaaggga gggcctaaag cacttgtaac tttgaaccgt   1440

ctgtctggag gtcagagcct gttggaaagc aggggtagag gggagccctg gaagcagggc   1500

ttttccggat gcctaggggt gggcagtgcc agcccctcct caccactctt ccccttgcag   1560

tggaggagag agccagagtg gatactattt tttattaaat atattattat atgttaataa   1620

aaaaatcata tcaaaccc                                                 1638


<210>  791
<211>  373
<212>  PRT
<213>  Homo sapiens

<400>  791


Met Ala Thr Ser Gly Ala Asn Gly Pro Gly Ser Ala Thr Ala Ser Ala 
1               5                   10                  15      


Ser Asn Pro Arg Lys Phe Ser Glu Lys Ile Ala Leu Gln Lys Gln Arg 
            20                  25                  30          


Gln Ala Ser Leu Ser Ser Pro Gln Pro Gln Leu Gln Gly Ser His Ser 
        35                  40                  45              


His Pro Ser Leu Pro Ala Ser Ser Leu Ala Arg His Val Leu Pro Thr 
    50                  55                  60                  


Thr Ser Leu Gly His Pro Ser Leu Ser Ala Pro Ala Leu Ser Ser Ser 
65                  70                  75                  80  


Ser Ser Ser Ser Ser Thr Ser Ser Pro Val Leu Gly Ala Pro Ser Tyr 
                85                  90                  95      


Pro Ala Ser Thr Pro Gly Ala Ser Pro His His Arg Arg Val Pro Leu 
            100                 105                 110         


Ser Pro Leu Ser Leu Leu Ala Gly Pro Ala Asp Ala Arg Arg Ser Gln 
        115                 120                 125             


Gln Gln Leu Pro Lys Gln Phe Ser Pro Thr Met Ser Pro Thr Leu Ser 
    130                 135                 140                 


Ser Ile Thr Gln Gly Val Pro Leu Asp Thr Ser Lys Leu Ser Thr Asp 
145                 150                 155                 160 


Gln Arg Leu Pro Pro Tyr Pro Tyr Ser Ser Pro Ser Leu Val Leu Pro 
                165                 170                 175     


Thr Gln Pro His Thr Pro Lys Ser Leu Gln Gln Pro Gly Leu Pro Ser 
            180                 185                 190         


Gln Ser Cys Ser Val Gln Ser Ser Gly Gly Gln Pro Pro Gly Arg Gln 
        195                 200                 205             


Ser His Tyr Gly Thr Pro Tyr Pro Pro Gly Pro Ser Gly His Gly Gln 
    210                 215                 220                 


Gln Ser Tyr His Arg Pro Met Ser Asp Phe Asn Leu Gly Asn Leu Glu 
225                 230                 235                 240 


Gln Phe Ser Met Glu Ser Pro Ser Ala Ser Leu Val Leu Asp Pro Pro 
                245                 250                 255     


Gly Phe Ser Glu Gly Pro Gly Phe Leu Gly Gly Glu Gly Pro Met Gly 
            260                 265                 270         


Gly Pro Gln Asp Pro His Thr Phe Asn His Gln Asn Leu Thr His Cys 
        275                 280                 285             


Ser Arg His Gly Ser Gly Pro Asn Ile Ile Leu Thr Gly Asp Ser Ser 
    290                 295                 300                 


Pro Gly Phe Ser Lys Glu Ile Ala Ala Ala Leu Ala Gly Val Pro Gly 
305                 310                 315                 320 


Phe Glu Val Ser Ala Ala Gly Leu Glu Leu Gly Leu Gly Leu Glu Asp 
                325                 330                 335     


Glu Leu Arg Met Glu Pro Leu Gly Leu Glu Gly Leu Asn Met Leu Ser 
            340                 345                 350         


Asp Pro Cys Ala Leu Leu Pro Asp Pro Ala Val Glu Glu Ser Phe Arg 
        355                 360                 365             


Ser Asp Arg Leu Gln 
    370             

<210>  792
<211>  2678
<212>  DNA
<213>  Homo sapiens

<400>  792
cccggcggcc cccgcgcgca acaggtcagg gctaggctgg ggccgggttc gcggtgctcg     60

ctgaggcggc ggtggctacg gctggaggag ccgggccgag gccgcggcgg aggccgcggc    120

tggtactggg agggtggcag ggagggacgg ggaaggaaga tggcgacgtc gggggcgaac    180

gggcctggtt cggccacggc ctcggcttcc aatccgcgca aatttagtga gaagattgcg    240

ctgcagaagc agcgtcaggc cgaggagacg gcggccttcg aggaggtgat gatggacatc    300

ggctccaccc ggttacaggc ccaaaaactg cgactggcat acacaaggag ctctcattat    360

ggtgggtctc tgcccaatgt taaccagatt ggctctggcc tggccgagtt ccagagcccc    420

ctccactcac ctttggattc atctcggagc actcggcacc atgggctggt ggaacgggtg    480

cagcgagatc ctcgaagaat ggtgtcccca cttcgccgat acacccgcca cattgacagc    540

tctccctata gtcctgccta cttatctcct cccccagagt ctagctggcg aaggacgatg    600

gcctggggca atttccctgc agagaagggg cagttgtttc gactaccatc tgcacttaac    660

aggacaagct ctgactctgc ccttcataca agtgtgatga accccagtcc ccaggatacc    720

tacccaggcc ccacacctcc cagcatcctg cccagccgac gtgggggtat tctggatggt    780

gaaatggacc ccaaagtacc tgctattgag gagaacttgc tagatgacaa gcatttgctg    840

aagccatggg atgctaagaa gctatcctca tcctcttccc gacctcggtc ctgtgaagtc    900

cctggaatta acatctttcc atctcctgac cagcctgcca atgtgcctgt cctcccacct    960

gccatgaaca cggggggctc cctacctgac ctcaccaacc tgcactttcc cccaccactg   1020

cccacccccc tggaccctga agagacagcc taccctagcc tgagtggggg caacagtacc   1080

tccaatttga cccacaccat gactcacctg ggcatcagca ggggcatggg cctgggccca   1140

ggctatgatg caccaggact tcattcacct ctcagccacc catccctgca gtcctcccta   1200

agcaatccca acctccaggc ttccctgagc agtcctcagc cccagcttca gggctcccac   1260

agccacccct ctctgcctgc ctcctccttg gcccgccatg tactgcccac cacctccctg   1320

ggccacccct cactcagtgc tccggctctc tcctcctcct cttcctcctc ctccacttca   1380

tctcctgttt tgggcgcccc ctcttaccct gcttctaccc ctggggcctc cccccaccac   1440

cgccgtgtgc ccctcagccc cctgagtttg ctcgcgggcc cagccgacgc cagaaggtcc   1500

caacagcagc tgcccaaaca gttttcgcca acaatgtcac ccaccttgtc ttccatcact   1560

cagggcgtcc ccctggatac cagtaaactg tccactgacc agcggttacc cccataccca   1620

tacagctccc caagtctggt tctgcctacc cagccccaca ccccaaagtc tctacagcag   1680

ccagggctgc cctctcagtc ttgttcagtg cagtcctcag gtgggcagcc cccaggcagg   1740

cagtctcatt atgggacacc gtacccacct gggcccagtg ggcatgggca acagtcttac   1800

caccggccaa tgagtgactt caacctgggg aatctggagc agttcagcat ggagagccca   1860

tcagccagcc tggtgctgga tccccctggc ttttctgaag ggcctggatt tttagggggt   1920

gaggggccaa tgggtggccc ccaggatccc cacaccttca accaccagaa cttgacccac   1980

tgttcccgcc atggctcagg gcctaacatc atcctcacag gggactcctc tccaggtttc   2040

tctaaggaga ttgcagcagc cctggccgga gtgcctggct ttgaggtgtc agcagctgga   2100

ttggagctag ggcttgggct agaagatgag ctgcgcatgg agccactggg cctggaaggg   2160

ctaaacatgc tgagtgaccc ctgtgccctg ctgcctgatc ctgctgtgga ggagtcattc   2220

cgcagtgacc ggctccaatg agggcacctc atcaccatcc ctcttcttgg ccccatcccc   2280

caccaccatt cctttcctcc cttccccctg gcaggtagag actctactct ctgtccccag   2340

atcctctttc tagcatgaat gaaggatgcc aagaatgaga aaaagcaagg ggtttgtcca   2400

ggtggcccct gaattctgcg caagggatgg gcctggggga actcaaggga gggcctaaag   2460

cacttgtaac tttgaaccgt ctgtctggag gtcagagcct gttggaaagc aggggtagag   2520

gggagccctg gaagcagggc ttttccggat gcctaggggt gggcagtgcc agcccctcct   2580

caccactctt ccccttgcag tggaggagag agccagagtg gatactattt tttattaaat   2640

atattattat atgttaataa aaaaatcata tcaaaccc                           2678


<210>  793
<211>  693
<212>  PRT
<213>  Homo sapiens

<400>  793


Met Ala Thr Ser Gly Ala Asn Gly Pro Gly Ser Ala Thr Ala Ser Ala 
1               5                   10                  15      


Ser Asn Pro Arg Lys Phe Ser Glu Lys Ile Ala Leu Gln Lys Gln Arg 
            20                  25                  30          


Gln Ala Glu Glu Thr Ala Ala Phe Glu Glu Val Met Met Asp Ile Gly 
        35                  40                  45              


Ser Thr Arg Leu Gln Ala Gln Lys Leu Arg Leu Ala Tyr Thr Arg Ser 
    50                  55                  60                  


Ser His Tyr Gly Gly Ser Leu Pro Asn Val Asn Gln Ile Gly Ser Gly 
65                  70                  75                  80  


Leu Ala Glu Phe Gln Ser Pro Leu His Ser Pro Leu Asp Ser Ser Arg 
                85                  90                  95      


Ser Thr Arg His His Gly Leu Val Glu Arg Val Gln Arg Asp Pro Arg 
            100                 105                 110         


Arg Met Val Ser Pro Leu Arg Arg Tyr Thr Arg His Ile Asp Ser Ser 
        115                 120                 125             


Pro Tyr Ser Pro Ala Tyr Leu Ser Pro Pro Pro Glu Ser Ser Trp Arg 
    130                 135                 140                 


Arg Thr Met Ala Trp Gly Asn Phe Pro Ala Glu Lys Gly Gln Leu Phe 
145                 150                 155                 160 


Arg Leu Pro Ser Ala Leu Asn Arg Thr Ser Ser Asp Ser Ala Leu His 
                165                 170                 175     


Thr Ser Val Met Asn Pro Ser Pro Gln Asp Thr Tyr Pro Gly Pro Thr 
            180                 185                 190         


Pro Pro Ser Ile Leu Pro Ser Arg Arg Gly Gly Ile Leu Asp Gly Glu 
        195                 200                 205             


Met Asp Pro Lys Val Pro Ala Ile Glu Glu Asn Leu Leu Asp Asp Lys 
    210                 215                 220                 


His Leu Leu Lys Pro Trp Asp Ala Lys Lys Leu Ser Ser Ser Ser Ser 
225                 230                 235                 240 


Arg Pro Arg Ser Cys Glu Val Pro Gly Ile Asn Ile Phe Pro Ser Pro 
                245                 250                 255     


Asp Gln Pro Ala Asn Val Pro Val Leu Pro Pro Ala Met Asn Thr Gly 
            260                 265                 270         


Gly Ser Leu Pro Asp Leu Thr Asn Leu His Phe Pro Pro Pro Leu Pro 
        275                 280                 285             


Thr Pro Leu Asp Pro Glu Glu Thr Ala Tyr Pro Ser Leu Ser Gly Gly 
    290                 295                 300                 


Asn Ser Thr Ser Asn Leu Thr His Thr Met Thr His Leu Gly Ile Ser 
305                 310                 315                 320 


Arg Gly Met Gly Leu Gly Pro Gly Tyr Asp Ala Pro Gly Leu His Ser 
                325                 330                 335     


Pro Leu Ser His Pro Ser Leu Gln Ser Ser Leu Ser Asn Pro Asn Leu 
            340                 345                 350         


Gln Ala Ser Leu Ser Ser Pro Gln Pro Gln Leu Gln Gly Ser His Ser 
        355                 360                 365             


His Pro Ser Leu Pro Ala Ser Ser Leu Ala Arg His Val Leu Pro Thr 
    370                 375                 380                 


Thr Ser Leu Gly His Pro Ser Leu Ser Ala Pro Ala Leu Ser Ser Ser 
385                 390                 395                 400 


Ser Ser Ser Ser Ser Thr Ser Ser Pro Val Leu Gly Ala Pro Ser Tyr 
                405                 410                 415     


Pro Ala Ser Thr Pro Gly Ala Ser Pro His His Arg Arg Val Pro Leu 
            420                 425                 430         


Ser Pro Leu Ser Leu Leu Ala Gly Pro Ala Asp Ala Arg Arg Ser Gln 
        435                 440                 445             


Gln Gln Leu Pro Lys Gln Phe Ser Pro Thr Met Ser Pro Thr Leu Ser 
    450                 455                 460                 


Ser Ile Thr Gln Gly Val Pro Leu Asp Thr Ser Lys Leu Ser Thr Asp 
465                 470                 475                 480 


Gln Arg Leu Pro Pro Tyr Pro Tyr Ser Ser Pro Ser Leu Val Leu Pro 
                485                 490                 495     


Thr Gln Pro His Thr Pro Lys Ser Leu Gln Gln Pro Gly Leu Pro Ser 
            500                 505                 510         


Gln Ser Cys Ser Val Gln Ser Ser Gly Gly Gln Pro Pro Gly Arg Gln 
        515                 520                 525             


Ser His Tyr Gly Thr Pro Tyr Pro Pro Gly Pro Ser Gly His Gly Gln 
    530                 535                 540                 


Gln Ser Tyr His Arg Pro Met Ser Asp Phe Asn Leu Gly Asn Leu Glu 
545                 550                 555                 560 


Gln Phe Ser Met Glu Ser Pro Ser Ala Ser Leu Val Leu Asp Pro Pro 
                565                 570                 575     


Gly Phe Ser Glu Gly Pro Gly Phe Leu Gly Gly Glu Gly Pro Met Gly 
            580                 585                 590         


Gly Pro Gln Asp Pro His Thr Phe Asn His Gln Asn Leu Thr His Cys 
        595                 600                 605             


Ser Arg His Gly Ser Gly Pro Asn Ile Ile Leu Thr Gly Asp Ser Ser 
    610                 615                 620                 


Pro Gly Phe Ser Lys Glu Ile Ala Ala Ala Leu Ala Gly Val Pro Gly 
625                 630                 635                 640 


Phe Glu Val Ser Ala Ala Gly Leu Glu Leu Gly Leu Gly Leu Glu Asp 
                645                 650                 655     


Glu Leu Arg Met Glu Pro Leu Gly Leu Glu Gly Leu Asn Met Leu Ser 
            660                 665                 670         


Asp Pro Cys Ala Leu Leu Pro Asp Pro Ala Val Glu Glu Ser Phe Arg 
        675                 680                 685             


Ser Asp Arg Leu Gln 
    690             

<210>  794
<211>  1272
<212>  DNA
<213>  Homo sapiens

<400>  794
gctccagttc ccactgcaag agttcatcct ggccatgggc ttcttcctgg tcctggtgat     60

ggagcagatc acactggctt acaaggagca gtcagggccg tcacctctgg aggaaacaag    120

ggctctgctg ggaacagtga atggtgggcc gcagcattgg catgatgggc caggggtccc    180

acaggcgagt ggagccccag caaccccctc agccttgcgt gcctgtgtac tggtgttctc    240

cctggccctc cactccgtgt tcgaggggct ggcggtaggg ctgcagcgag accgggctcg    300

ggccatggag ctgtgcctgg ctttgctgct ccacaagggc atcctggctg tcagcctgtc    360

cctgcggctg ttgcagagcc accttagggc acaggtggtg gctggctgtg ggatcctctt    420

ctcatgcatg acacctctag gcatcgggct gggtgcagct ctggcagagt cggcaggacc    480

tctgcaccag ctggcccagt ctgtgctaga gggcatggca gctggcacct ttctctatat    540

cacctttctg gaaatcctgc cccaggagct ggccagttct gagcaaagga tcctcaaggt    600

cattctgctc ctagcaggct ttgccctgct cactggcctg ctcttcatcc aaatctaggg    660

ggcttcaaga gaggggcagg ggagattgat gatcaggtgc ccctgttctc ccttccctcc    720

cccagttgtg gggaatagga aggaaagggg aagggaaata ctgaggactg gcgccaaatg    780

gtctctccct gccaattttg gtatcttctc tggcctctcc agtcctgctt actcctctat    840

ttttaaagtg ccaaacaaat ccccttcctc tttctcaaag cacagtaatg tggcactgag    900

ccctacccag cacctcagtg aagggggcct gcttgctctt tattttggtc ccggatcctg    960

gggtggggca gaaatatttt ctgggctggg gtaggaggaa ggttgttgca gccatctact   1020

gctgctgtac cctaggaata tggggacatg gacatggtgt cccatgccca gatgataaac   1080

actgagctgc caaaacattt ttttaaatac acccgaggag cccaaggggg aagggcaatg   1140

cctaccccca gcgttatttt tggggaggga gggctgtgca tagggacata ttctttagaa   1200

tctattttat taactgacct gttttgggac ctgttaccca aataaaagat gtttctagac   1260

atctgtacag ta                                                       1272


<210>  795
<211>  101
<212>  PRT
<213>  Homo sapiens

<400>  795


Met Ile Arg Cys Pro Cys Ser Pro Phe Pro Pro Pro Val Val Gly Asn 
1               5                   10                  15      


Arg Lys Glu Arg Gly Arg Glu Ile Leu Arg Thr Gly Ala Lys Trp Ser 
            20                  25                  30          


Leu Pro Ala Asn Phe Gly Ile Phe Ser Gly Leu Ser Ser Pro Ala Tyr 
        35                  40                  45              


Ser Ser Ile Phe Lys Val Pro Asn Lys Ser Pro Ser Ser Phe Ser Lys 
    50                  55                  60                  


His Ser Asn Val Ala Leu Ser Pro Thr Gln His Leu Ser Glu Gly Gly 
65                  70                  75                  80  


Leu Leu Ala Leu Tyr Phe Gly Pro Gly Ser Trp Gly Gly Ala Glu Ile 
                85                  90                  95      


Phe Ser Gly Leu Gly 
            100     

<210>  796
<211>  1576
<212>  DNA
<213>  Homo sapiens

<400>  796
gctccagttc ccactgcaag agttcatcct ggccatgggc ttcttcctgg tcctggtgat     60

ggagcagatc acactggctt acaaggagca gtcagggccg tcacctctgg aggaaacaag    120

ggctctgctg ggaacagtga atggtgggcc gcagcattgg catgatgggc caggggtccc    180

acaggcgagt ggagccccag caaccccctc agccttgcgt gcctgtgtac tggtgttctc    240

cctggccctc cactccgtgt tcgaggggct ggcggtaggg ctgcagcgag accgggctcg    300

ggccatggag ctgtgcctgg ctttgctgct ccacaagggc atcctggctg tcagcctgtc    360

cctgcggctg ttgcagagcc accttagggc acaggtggtg gctggctgtg ggatcctctt    420

ctcatgcatg acacctctag gcatcgggct gggtgcagct ctggcagagt cggcaggacc    480

tctgcaccag ctggcccagt ctgtgctaga gggcatggca gctggcacct ttctctatat    540

cacctttctg gaaatcctgc tcttcatcca aatctagggg gcttcaagag aggggcaggg    600

gagattgatg atcaggtgcc cctgttctcc cttccctccc ccagttgtgg ggaataggaa    660

ggaaagggga agggaaatac tgaggaccaa aaagttctct gggagctaaa gatagagcct    720

ttggggctat ctgactaatg agagggaagt gggcagacaa gaggctggcc ccagtcccaa    780

ggaacaagag atggtcaagt cgctagagac atatcagggg acattaggat tggggaagac    840

acttgactgc tagaatcaga ggttggacac tatacataag gacaggctca catgggaggc    900

tggaggtggg tacccagctg ctgtggaacg ggtatggaca ggtcataaac ctagagtcag    960

tgtcctgttg gtcctagccc atttcagcac cctgccactt ggagtggacc cctcctactc   1020

ttcttagcgc ctaccctcat acctatctcc ctcctcccat ctcctagggg actggcgcca   1080

aatggtctct ccctgccaat tttggtatct tctctggcct ctccagtcct gcttactcct   1140

ctatttttaa agtgccaaac aaatcccctt cctctttctc aaagcacagt aatgtggcac   1200

tgagccctac ccagcacctc agtgaagggg gcctgcttgc tctttatttt ggtcccggat   1260

cctggggtgg ggcagaaata ttttctgggc tggggtagga ggaaggttgt tgcagccatc   1320

tactgctgct gtaccctagg aatatgggga catggacatg gtgtcccatg cccagatgat   1380

aaacactgag ctgccaaaac atttttttaa atacacccga ggagcccaag ggggaagggc   1440

aatgcctacc cccagcgtta tttttgggga gggagggctg tgcataggga catattcttt   1500

agaatctatt ttattaactg acctgttttg ggacctgtta cccaaataaa agatgtttct   1560

agacatctgt acagta                                                   1576


<210>  797
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  797


Met Gly Phe Phe Leu Val Leu Val Met Glu Gln Ile Thr Leu Ala Tyr 
1               5                   10                  15      


Lys Glu Gln Ser Gly Pro Ser Pro Leu Glu Glu Thr Arg Ala Leu Leu 
            20                  25                  30          


Gly Thr Val Asn Gly Gly Pro Gln His Trp His Asp Gly Pro Gly Val 
        35                  40                  45              


Pro Gln Ala Ser Gly Ala Pro Ala Thr Pro Ser Ala Leu Arg Ala Cys 
    50                  55                  60                  


Val Leu Val Phe Ser Leu Ala Leu His Ser Val Phe Glu Gly Leu Ala 
65                  70                  75                  80  


Val Gly Leu Gln Arg Asp Arg Ala Arg Ala Met Glu Leu Cys Leu Ala 
                85                  90                  95      


Leu Leu Leu His Lys Gly Ile Leu Ala Val Ser Leu Ser Leu Arg Leu 
            100                 105                 110         


Leu Gln Ser His Leu Arg Ala Gln Val Val Ala Gly Cys Gly Ile Leu 
        115                 120                 125             


Phe Ser Cys Met Thr Pro Leu Gly Ile Gly Leu Gly Ala Ala Leu Ala 
    130                 135                 140                 


Glu Ser Ala Gly Pro Leu His Gln Leu Ala Gln Ser Val Leu Glu Gly 
145                 150                 155                 160 


Met Ala Ala Gly Thr Phe Leu Tyr Ile Thr Phe Leu Glu Ile Leu Leu 
                165                 170                 175     


Phe Ile Gln Ile 
            180 

<210>  798
<211>  1764
<212>  DNA
<213>  Homo sapiens

<400>  798
ctagtaagct gtttcgcggg gggcgtcttt ttggccactt gtctcctgga cctgctgcct     60

gactacctgg ctgccataga tgaggccctg gcagccttgc acgtgacgct ccagttccca    120

ctgcaagagt tcatcctggc catgggcttc ttcctggtcc tggtgatgga gcagatcaca    180

ctggcttaca aggagcagtc agggccgtca cctctggagg aaacaagggc tctgctggga    240

acagtgaatg gtgggccgca gcattggcat gatgggccag gggtcccaca ggcgagtgga    300

gccccagcaa ccccctcagc cttgcgtgcc tgtgtactgg tgttctccct ggccctccac    360

tccgtgttcg aggggctggc ggtagggctg cagcgagacc gggctcgggc catggagctg    420

tgcctggctt tgctgctcca caagggcatc ctggctgtca gcctgtccct gcggctgttg    480

cagagccacc ttagggcaca ggtggtggct ggctgtggga tcctcttctc atgcatgaca    540

cctctaggca tcgggctggg tgcagctctg gcagagtcgg caggacctct gcaccagctg    600

gcccagtctg tgctagaggg catggcagct ggcacctttc tctatatcac ctttctggaa    660

atcctgcccc aggagctggc cagttctgag caaaggatcc tcaaggtcat tctgctccta    720

gcaggctttg ccctgctcac tggcctgctc ttcatccaaa tctagggggc ttcaagagag    780

gggcagggga gattgatgat caggtgcccc tgttctccct tccctccccc agttgtgggg    840

aataggaagg aaaggggaag ggaaatactg aggaccaaaa agttctctgg gagctaaaga    900

tagagccttt ggggctatct gactaatgag agggaagtgg gcagacaaga ggctggcccc    960

agtcccaagg aacaagagat ggtcaagtcg ctagagacat atcaggggac attaggattg   1020

gggaagacac ttgactgcta gaatcagagg ttggacacta tacataagga caggctcaca   1080

tgggaggctg gaggtgggta cccagctgct gtggaacggg tatggacagg tcataaacct   1140

agagtcagtg tcctgttggt cctagcccat ttcagcaccc tgccacttgg agtggacccc   1200

tcctactctt cttagcgcct accctcatac ctatctccct cctcccatct cctaggggac   1260

tggcgccaaa tggtctctcc ctgccaattt tggtatcttc tctggcctct ccagtcctgc   1320

ttactcctct atttttaaag tgccaaacaa atccccttcc tctttctcaa agcacagtaa   1380

tgtggcactg agccctaccc agcacctcag tgaagggggc ctgcttgctc tttattttgg   1440

tcccggatcc tggggtgggg cagaaatatt ttctgggctg gggtaggagg aaggttgttg   1500

cagccatcta ctgctgctgt accctaggaa tatggggaca tggacatggt gtcccatgcc   1560

cagatgataa acactgagct gccaaaacat ttttttaaat acacccgagg agcccaaggg   1620

ggaagggcaa tgcctacccc cagcgttatt tttggggagg gagggctgtg catagggaca   1680

tattctttag aatctatttt attaactgac ctgttttggg acctgttacc caaataaaag   1740

atgtttctag acatctgtac agta                                          1764


<210>  799
<211>  207
<212>  PRT
<213>  Homo sapiens

<400>  799


Met Gly Phe Phe Leu Val Leu Val Met Glu Gln Ile Thr Leu Ala Tyr 
1               5                   10                  15      


Lys Glu Gln Ser Gly Pro Ser Pro Leu Glu Glu Thr Arg Ala Leu Leu 
            20                  25                  30          


Gly Thr Val Asn Gly Gly Pro Gln His Trp His Asp Gly Pro Gly Val 
        35                  40                  45              


Pro Gln Ala Ser Gly Ala Pro Ala Thr Pro Ser Ala Leu Arg Ala Cys 
    50                  55                  60                  


Val Leu Val Phe Ser Leu Ala Leu His Ser Val Phe Glu Gly Leu Ala 
65                  70                  75                  80  


Val Gly Leu Gln Arg Asp Arg Ala Arg Ala Met Glu Leu Cys Leu Ala 
                85                  90                  95      


Leu Leu Leu His Lys Gly Ile Leu Ala Val Ser Leu Ser Leu Arg Leu 
            100                 105                 110         


Leu Gln Ser His Leu Arg Ala Gln Val Val Ala Gly Cys Gly Ile Leu 
        115                 120                 125             


Phe Ser Cys Met Thr Pro Leu Gly Ile Gly Leu Gly Ala Ala Leu Ala 
    130                 135                 140                 


Glu Ser Ala Gly Pro Leu His Gln Leu Ala Gln Ser Val Leu Glu Gly 
145                 150                 155                 160 


Met Ala Ala Gly Thr Phe Leu Tyr Ile Thr Phe Leu Glu Ile Leu Pro 
                165                 170                 175     


Gln Glu Leu Ala Ser Ser Glu Gln Arg Ile Leu Lys Val Ile Leu Leu 
            180                 185                 190         


Leu Ala Gly Phe Ala Leu Leu Thr Gly Leu Leu Phe Ile Gln Ile 
        195                 200                 205         

<210>  800
<211>  2163
<212>  DNA
<213>  Homo sapiens

<400>  800
agtgtcgcct cagtccgtcc cgggaccgca gactcttagg gcccctctct ttggccatct     60

gcctctaggt cccatcctgg ggcctgaagc gcttgttctc tgcgctggga aaaggggaac    120

gatggagcga tccagcaccc aaacttaccc tgtccaggtc tgagagtcac tggagctacc    180

agaagcatca tggggccctg gggagagcca gagctcctgg tgtggcgccc cgaggcggta    240

gcttcagagc ctccagtgcc tgtggggctg gaggtgaagt tgggggccct ggtgctgctg    300

ctggtgctca ccctcctctg cagcctggtg cccatctgtg tgctgcgccg gccaggagct    360

aaccatgaag gctcagcttc ccgccagaaa gccctgagcc tagtaagctg tttcgcgggg    420

ggcgtctttt tggccacttg tctcctggac ctgctgcctg actacctggc tgccatagat    480

gaggccctgg cagccttgca cgtgacgctc cagttcccac tgcaagagtt catcctggcc    540

atgggcttct tcctggtcct ggtgatggag cagatcacac tggcttacaa ggagcagtca    600

gggccgtcac ctctggagga aacaagggct ctgctgggaa cagtgaatgg tgggccgcag    660

cattggcatg atgggccagg ggtcccacag gcgagtggag ccccagcaac cccctcagcc    720

ttgcgtgcct gtgtactggt gttctccctg gccctccact ccgtgttcga ggggctggcg    780

gtagggctgc agcgagaccg ggctcgggcc atggagctgt gcctggcttt gctgctccac    840

aagggcatcc tggctgtcag cctgtccctg cggctgttgc agagccacct tagggcacag    900

gtggtggctg gctgtgggat cctcttctca tgcatgacac ctctaggcat cgggctgggt    960

gcagctctgg cagagtcggc aggacctctg caccagctgg cccagtctgt gctagagggc   1020

atggcagctg gcacctttct ctatatcacc tttctggaaa tcctgcccca ggagctggcc   1080

agttctgagc aaaggatcct caaggtcatt ctgctcctag caggctttgc cctgctcact   1140

ggcctgctct tcatccaaat ctagggggct tcaagagagg ggcaggggag attgatgatc   1200

aggtgcccct gttctccctt ccctccccca gttgtgggga ataggaagga aaggggaagg   1260

gaaatactga ggaccaaaaa gttctctggg agctaaagat agagcctttg gggctatctg   1320

actaatgaga gggaagtggg cagacaagag gctggcccca gtcccaagga acaagagatg   1380

gtcaagtcgc tagagacata tcaggggaca ttaggattgg ggaagacact tgactgctag   1440

aatcagaggt tggacactat acataaggac aggctcacat gggaggctgg aggtgggtac   1500

ccagctgctg tggaacgggt atggacaggt cataaaccta gagtcagtgt cctgttggtc   1560

ctagcccatt tcagcaccct gccacttgga gtggacccct cctactcttc ttagcgccta   1620

ccctcatacc tatctccctc ctcccatctc ctaggggact ggcgccaaat ggtctctccc   1680

tgccaatttt ggtatcttct ctggcctctc cagtcctgct tactcctcta tttttaaagt   1740

gccaaacaaa tccccttcct ctttctcaaa gcacagtaat gtggcactga gccctaccca   1800

gcacctcagt gaagggggcc tgcttgctct ttattttggt cccggatcct ggggtggggc   1860

agaaatattt tctgggctgg ggtaggagga aggttgttgc agccatctac tgctgctgta   1920

ccctaggaat atggggacat ggacatggtg tcccatgccc agatgataaa cactgagctg   1980

ccaaaacatt tttttaaata cacccgagga gcccaagggg gaagggcaat gcctaccccc   2040

agcgttattt ttggggaggg agggctgtgc atagggacat attctttaga atctatttta   2100

ttaactgacc tgttttggga cctgttaccc aaataaaaga tgtttctaga catctgtaca   2160

gta                                                                 2163


<210>  801
<211>  324
<212>  PRT
<213>  Homo sapiens

<400>  801


Met Gly Pro Trp Gly Glu Pro Glu Leu Leu Val Trp Arg Pro Glu Ala 
1               5                   10                  15      


Val Ala Ser Glu Pro Pro Val Pro Val Gly Leu Glu Val Lys Leu Gly 
            20                  25                  30          


Ala Leu Val Leu Leu Leu Val Leu Thr Leu Leu Cys Ser Leu Val Pro 
        35                  40                  45              


Ile Cys Val Leu Arg Arg Pro Gly Ala Asn His Glu Gly Ser Ala Ser 
    50                  55                  60                  


Arg Gln Lys Ala Leu Ser Leu Val Ser Cys Phe Ala Gly Gly Val Phe 
65                  70                  75                  80  


Leu Ala Thr Cys Leu Leu Asp Leu Leu Pro Asp Tyr Leu Ala Ala Ile 
                85                  90                  95      


Asp Glu Ala Leu Ala Ala Leu His Val Thr Leu Gln Phe Pro Leu Gln 
            100                 105                 110         


Glu Phe Ile Leu Ala Met Gly Phe Phe Leu Val Leu Val Met Glu Gln 
        115                 120                 125             


Ile Thr Leu Ala Tyr Lys Glu Gln Ser Gly Pro Ser Pro Leu Glu Glu 
    130                 135                 140                 


Thr Arg Ala Leu Leu Gly Thr Val Asn Gly Gly Pro Gln His Trp His 
145                 150                 155                 160 


Asp Gly Pro Gly Val Pro Gln Ala Ser Gly Ala Pro Ala Thr Pro Ser 
                165                 170                 175     


Ala Leu Arg Ala Cys Val Leu Val Phe Ser Leu Ala Leu His Ser Val 
            180                 185                 190         


Phe Glu Gly Leu Ala Val Gly Leu Gln Arg Asp Arg Ala Arg Ala Met 
        195                 200                 205             


Glu Leu Cys Leu Ala Leu Leu Leu His Lys Gly Ile Leu Ala Val Ser 
    210                 215                 220                 


Leu Ser Leu Arg Leu Leu Gln Ser His Leu Arg Ala Gln Val Val Ala 
225                 230                 235                 240 


Gly Cys Gly Ile Leu Phe Ser Cys Met Thr Pro Leu Gly Ile Gly Leu 
                245                 250                 255     


Gly Ala Ala Leu Ala Glu Ser Ala Gly Pro Leu His Gln Leu Ala Gln 
            260                 265                 270         


Ser Val Leu Glu Gly Met Ala Ala Gly Thr Phe Leu Tyr Ile Thr Phe 
        275                 280                 285             


Leu Glu Ile Leu Pro Gln Glu Leu Ala Ser Ser Glu Gln Arg Ile Leu 
    290                 295                 300                 


Lys Val Ile Leu Leu Leu Ala Gly Phe Ala Leu Leu Thr Gly Leu Leu 
305                 310                 315                 320 


Phe Ile Gln Ile 
                

<210>  802
<211>  2410
<212>  DNA
<213>  Homo sapiens

<400>  802
gtcggctgcc caggcctccc cgggcccggg aacaggagtc ccagctcacg cattcttcat     60

ctgcttcccg cgacgcttgg cggcctcgca ccccgcctcc tggagcccgg actttcaggc    120

accgccctca gtgtcgcctc agtccgtccc gggaccgcag actcttaggg cccctctctt    180

tggccatctg cctctaggtc ccatcctggg gcctgaagcg cttgttctct gcgctgggaa    240

aaggggaacg atggagcgat ccagcaccca aacttaccct gtccaggtgg cccacgaagc    300

tacccaagac atctctgcac agccctagcc tttttggctt cacccactcc gttcgggagt    360

tggggacccg gcctctacat tccttagggg aactccagct ccaggtctga gagtcactgg    420

agctaccaga agcatcatgg ggccctgggg agagccagag ctcctggtgt ggcgccccga    480

ggcggtagct tcagagcctc cagtgcctgt ggggctggag gtgaagttgg gggccctggt    540

gctgctgctg gtgctcaccc tcctctgcag cctggtgccc atctgtgtgc tgcgccggcc    600

aggagctaac catgaaggct cagcttcccg ccagaaagcc ctgagcctag taagctgttt    660

cgcggggggc gtctttttgg ccacttgtct cctggacctg ctgcctgact acctggctgc    720

catagatgag gccctggcag ccttgcacgt gacgctccag ttcccactgc aagagttcat    780

cctggccatg ggcttcttcc tggtcctggt gatggagcag atcacactgg cttacaagga    840

gcagtcaggg ccgtcacctc tggaggaaac aagggctctg ctgggaacag tgaatggtgg    900

gccgcagcat tggcatgatg ggccaggggt cccacaggcg agtggagccc cagcaacccc    960

ctcagccttg cgtgcctgtg tactggtgtt ctccctggcc ctccactccg tgttcgaggg   1020

gctggcggta gggctgcagc gagaccgggc tcgggccatg gagctgtgcc tggctttgct   1080

gctccacaag ggcatcctgg ctgtcagcct gtccctgcgg ctgttgcaga gccaccttag   1140

ggcacaggtg gtggctggct gtgggatcct cttctcatgc atgacacctc taggcatcgg   1200

gctgggtgca gctctggcag agtcggcagg acctctgcac cagctggccc agtctgtgct   1260

agagggcatg gcagctggca cctttctcta tatcaccttt ctggaaatcc tgccccagga   1320

gctggccagt tctgagcaaa ggatcctcaa ggtcattctg ctcctagcag gctttgccct   1380

gctcactggc ctgctcttca tccaaatcta gggggcttca agagaggggc aggggagatt   1440

gatgatcagg tgcccctgtt ctcccttccc tcccccagtt gtggggaata ggaaggaaag   1500

gggaagggaa atactgagga ccaaaaagtt ctctgggagc taaagataga gcctttgggg   1560

ctatctgact aatgagaggg aagtgggcag acaagaggct ggccccagtc ccaaggaaca   1620

agagatggtc aagtcgctag agacatatca ggggacatta ggattgggga agacacttga   1680

ctgctagaat cagaggttgg acactataca taaggacagg ctcacatggg aggctggagg   1740

tgggtaccca gctgctgtgg aacgggtatg gacaggtcat aaacctagag tcagtgtcct   1800

gttggtccta gcccatttca gcaccctgcc acttggagtg gacccctcct actcttctta   1860

gcgcctaccc tcatacctat ctccctcctc ccatctccta ggggactggc gccaaatggt   1920

ctctccctgc caattttggt atcttctctg gcctctccag tcctgcttac tcctctattt   1980

ttaaagtgcc aaacaaatcc ccttcctctt tctcaaagca cagtaatgtg gcactgagcc   2040

ctacccagca cctcagtgaa gggggcctgc ttgctcttta ttttggtccc ggatcctggg   2100

gtggggcaga aatattttct gggctggggt aggaggaagg ttgttgcagc catctactgc   2160

tgctgtaccc taggaatatg gggacatgga catggtgtcc catgcccaga tgataaacac   2220

tgagctgcca aaacattttt ttaaatacac ccgaggagcc caagggggaa gggcaatgcc   2280

tacccccagc gttatttttg gggagggagg gctgtgcata gggacatatt ctttagaatc   2340

tattttatta actgacctgt tttgggacct gttacccaaa taaaagatgt ttctagacat   2400

ctgtacagta                                                          2410


<210>  803
<211>  324
<212>  PRT
<213>  Homo sapiens

<400>  803


Met Gly Pro Trp Gly Glu Pro Glu Leu Leu Val Trp Arg Pro Glu Ala 
1               5                   10                  15      


Val Ala Ser Glu Pro Pro Val Pro Val Gly Leu Glu Val Lys Leu Gly 
            20                  25                  30          


Ala Leu Val Leu Leu Leu Val Leu Thr Leu Leu Cys Ser Leu Val Pro 
        35                  40                  45              


Ile Cys Val Leu Arg Arg Pro Gly Ala Asn His Glu Gly Ser Ala Ser 
    50                  55                  60                  


Arg Gln Lys Ala Leu Ser Leu Val Ser Cys Phe Ala Gly Gly Val Phe 
65                  70                  75                  80  


Leu Ala Thr Cys Leu Leu Asp Leu Leu Pro Asp Tyr Leu Ala Ala Ile 
                85                  90                  95      


Asp Glu Ala Leu Ala Ala Leu His Val Thr Leu Gln Phe Pro Leu Gln 
            100                 105                 110         


Glu Phe Ile Leu Ala Met Gly Phe Phe Leu Val Leu Val Met Glu Gln 
        115                 120                 125             


Ile Thr Leu Ala Tyr Lys Glu Gln Ser Gly Pro Ser Pro Leu Glu Glu 
    130                 135                 140                 


Thr Arg Ala Leu Leu Gly Thr Val Asn Gly Gly Pro Gln His Trp His 
145                 150                 155                 160 


Asp Gly Pro Gly Val Pro Gln Ala Ser Gly Ala Pro Ala Thr Pro Ser 
                165                 170                 175     


Ala Leu Arg Ala Cys Val Leu Val Phe Ser Leu Ala Leu His Ser Val 
            180                 185                 190         


Phe Glu Gly Leu Ala Val Gly Leu Gln Arg Asp Arg Ala Arg Ala Met 
        195                 200                 205             


Glu Leu Cys Leu Ala Leu Leu Leu His Lys Gly Ile Leu Ala Val Ser 
    210                 215                 220                 


Leu Ser Leu Arg Leu Leu Gln Ser His Leu Arg Ala Gln Val Val Ala 
225                 230                 235                 240 


Gly Cys Gly Ile Leu Phe Ser Cys Met Thr Pro Leu Gly Ile Gly Leu 
                245                 250                 255     


Gly Ala Ala Leu Ala Glu Ser Ala Gly Pro Leu His Gln Leu Ala Gln 
            260                 265                 270         


Ser Val Leu Glu Gly Met Ala Ala Gly Thr Phe Leu Tyr Ile Thr Phe 
        275                 280                 285             


Leu Glu Ile Leu Pro Gln Glu Leu Ala Ser Ser Glu Gln Arg Ile Leu 
    290                 295                 300                 


Lys Val Ile Leu Leu Leu Ala Gly Phe Ala Leu Leu Thr Gly Leu Leu 
305                 310                 315                 320 


Phe Ile Gln Ile 
                

<210>  804
<211>  2423
<212>  DNA
<213>  Homo sapiens

<400>  804
ggcagcgggg tccatgtcgg ctgcccaggc ctccccgggc ccgggaacag gagtcccagc     60

tcacgcattc ttcatctgct tcccgcgacg cttggcggcc tcgcaccccg cctcctggag    120

cccggacttt caggcaccgc cctcagtgtc gcctcagtcc gtcccgggac cgcagactct    180

tagggcccct ctctttggcc atctgcctct aggtcccatc ctggggcctg aagcgcttgt    240

tctctgcgct gggaaaaggg gaacgatgga gcgatccagc acccaaactt accctgtcca    300

ggtggcccac gaagctaccc aagacatctc tgcacagccc tagccttttt ggcttcaccc    360

actccgttcg ggagttgggg acccggcctc tacattcctt aggggaactc cagctccagg    420

tcctatttgg aggcggctcc tagtttccta gttttctggg ggcaccaggt gaaagggtga    480

tgagatatcc atacagcctt tctcatgcct cggtttcccc cgtgcagtct ccctgaataa    540

gtcacttggg aaagaaagtg tgagaagaga ggaatgttcc tggtacagga gtagatgagt    600

caccctgggt aggggaaggt cacaaagtgg ctggggccag ggagctgcac tctgctgacc    660

aagcttcccc attccttgcc ccatcttcct ttgcatgatt tttcccaacc actctggtct    720

gtcttcctag gtctgagagt cactggagct accagaagca tcatggggcc ctggggagag    780

ccagagctcc tggtgtggcg ccccgaggcg gtagcttcag agcctccagt gcctgtgggg    840

ctggaggtga agttgggggc cctggtgctg ctgctggtgc tcaccctcct ctgctgggaa    900

cagtgaatgg tgggccgcag cattggcatg atgggccagg ggtcccacag gcgagtggag    960

ccccagcaac cccctcagcc ttgcgtgcct gtgtactggt gttctccctg gccctccact   1020

ccgtgttcga ggggctggcg gtagggctgc agcgagaccg ggctcgggcc atggagctgt   1080

gcctggcttt gctgctccac aagggcatcc tggctgtcag cctgtccctg cggctgttgc   1140

agagccacct tagggcacag gtggtggctg gctgtgggat cctcttctca tgcatgacac   1200

ctctaggcat cgggctgggt gcagctctgg cagagtcggc aggacctctg caccagctgg   1260

cccagtctgt gctagagggc atggcagctg gcacctttct ctatatcacc tttctggaaa   1320

tcctgcccca ggagctggcc agttctgagc aaaggatcct caaggtcatt ctgctcctag   1380

caggctttgc cctgctcact ggcctgctct tcatccaaat ctagggggct tcaagagagg   1440

ggcaggggag attgatgatc aggtgcccct gttctccctt ccctccccca gttgtgggga   1500

ataggaagga aaggggaagg gaaatactga ggaccaaaaa gttctctggg agctaaagat   1560

agagcctttg gggctatctg actaatgaga gggaagtggg cagacaagag gctggcccca   1620

gtcccaagga acaagagatg gtcaagtcgc tagagacata tcaggggaca ttaggattgg   1680

ggaagacact tgactgctag aatcagaggt tggacactat acataaggac aggctcacat   1740

gggaggctgg aggtgggtac ccagctgctg tggaacgggt atggacaggt cataaaccta   1800

gagtcagtgt cctgttggtc ctagcccatt tcagcaccct gccacttgga gtggacccct   1860

cctactcttc ttagcgccta ccctcatacc tatctccctc ctcccatctc ctaggggact   1920

ggcgccaaat ggtctctccc tgccaatttt ggtatcttct ctggcctctc cagtcctgct   1980

tactcctcta tttttaaagt gccaaacaaa tccccttcct ctttctcaaa gcacagtaat   2040

gtggcactga gccctaccca gcacctcagt gaagggggcc tgcttgctct ttattttggt   2100

cccggatcct ggggtggggc agaaatattt tctgggctgg ggtaggagga aggttgttgc   2160

agccatctac tgctgctgta ccctaggaat atggggacat ggacatggtg tcccatgccc   2220

agatgataaa cactgagctg ccaaaacatt tttttaaata cacccgagga gcccaagggg   2280

gaagggcaat gcctaccccc agcgttattt ttggggaggg agggctgtgc atagggacat   2340

attctttaga atctatttta ttaactgacc tgttttggga cctgttaccc aaataaaaga   2400

tgtttctaga catctgtaca gta                                           2423


<210>  805
<211>  47
<212>  PRT
<213>  Homo sapiens

<400>  805


Met Gly Pro Trp Gly Glu Pro Glu Leu Leu Val Trp Arg Pro Glu Ala 
1               5                   10                  15      


Val Ala Ser Glu Pro Pro Val Pro Val Gly Leu Glu Val Lys Leu Gly 
            20                  25                  30          


Ala Leu Val Leu Leu Leu Val Leu Thr Leu Leu Cys Trp Glu Gln 
        35                  40                  45          

<210>  806
<211>  2760
<212>  DNA
<213>  Homo sapiens

<400>  806
tcgcgaggtg agtgcgggct gtctggcagc ggggtccatg tcggctgccc aggcctcccc     60

gggcccggga acaggagtcc cagctcacgc attcttcatc tgcttcccgc gacgcttggc    120

ggcctcgcac cccgcctcct ggagcccgga ctttcaggca ccgccctcag tgtcgcctca    180

gtccgtcccg ggaccgcaga ctcttagggc ccctctcttt ggccatctgc ctctaggtcc    240

catcctgggg cctgaagcgc ttgttctctg cgctgggaaa aggggaacga tggagcgatc    300

cagcacccaa acttaccctg tccaggtggc ccacgaagct acccaagaca tctctgcaca    360

gccctagcct ttttggcttc acccactccg ttcgggagtt ggggacccgg cctctacatt    420

ccttagggga actccagctc caggtcctat ttggaggcgg ctcctagttt cctagttttc    480

tgggggcacc aggtgaaagg gtgatgagat atccatacag cctttctcat gcctcggttt    540

cccccgtgca gtctccctga ataagtcact tgggaaagaa agtgtgagaa gagaggaatg    600

ttcctggtac aggagtagat gagtcaccct gggtagggga aggtcacaaa gtggctgggg    660

ccagggagct gcactctgct gaccaagctt ccccattcct tgccccatct tcctttgcat    720

gatttttccc aaccactctg gtctgtcttc ctaggtctga gagtcactgg agctaccaga    780

agcatcatgg ggccctgggg agagccagag ctcctggtgt ggcgccccga ggcggtagct    840

tcagagcctc cagtgcctgt ggggctggag gtgaagttgg gggccctggt gctgctgctg    900

gtgctcaccc tcctctgcag cctggtgccc atctgtgtgc tgcgccggcc aggagctaac    960

catgaaggct cagcttcccg ccagaaagcc ctgagcctag taagctgttt cgcggggggc   1020

gtctttttgg ccacttgtct cctggacctg ctgcctgact acctggctgc catagatgag   1080

gccctggcag ccttgcacgt gacgctccag ttcccactgc aagagttcat cctggccatg   1140

ggcttcttcc tggtcctggt gatggagcag atcacactgg cttacaagga gcagtcaggg   1200

ccgtcacctc tggaggaaac aagggctctg ctgggaacag tgaatggtgg gccgcagcat   1260

tggcatgatg ggccaggggt cccacaggcg agtggagccc cagcaacccc ctcagccttg   1320

cgtgcctgtg tactggtgtt ctccctggcc ctccactccg tgttcgaggg gctggcggta   1380

gggctgcagc gagaccgggc tcgggccatg gagctgtgcc tggctttgct gctccacaag   1440

ggcatcctgg ctgtcagcct gtccctgcgg ctgttgcaga gccaccttag ggcacaggtg   1500

gtggctggct gtgggatcct cttctcatgc atgacacctc taggcatcgg gctgggtgca   1560

gctctggcag agtcggcagg acctctgcac cagctggccc agtctgtgct agagggcatg   1620

gcagctggca cctttctcta tatcaccttt ctggaaatcc tgccccagga gctggccagt   1680

tctgagcaaa ggatcctcaa ggtcattctg ctcctagcag gctttgccct gctcactggc   1740

ctgctcttca tccaaatcta gggggcttca agagaggggc aggggagatt gatgatcagg   1800

tgcccctgtt ctcccttccc tcccccagtt gtggggaata ggaaggaaag gggaagggaa   1860

atactgagga ccaaaaagtt ctctgggagc taaagataga gcctttgggg ctatctgact   1920

aatgagaggg aagtgggcag acaagaggct ggccccagtc ccaaggaaca agagatggtc   1980

aagtcgctag agacatatca ggggacatta ggattgggga agacacttga ctgctagaat   2040

cagaggttgg acactataca taaggacagg ctcacatggg aggctggagg tgggtaccca   2100

gctgctgtgg aacgggtatg gacaggtcat aaacctagag tcagtgtcct gttggtccta   2160

gcccatttca gcaccctgcc acttggagtg gacccctcct actcttctta gcgcctaccc   2220

tcatacctat ctccctcctc ccatctccta ggggactggc gccaaatggt ctctccctgc   2280

caattttggt atcttctctg gcctctccag tcctgcttac tcctctattt ttaaagtgcc   2340

aaacaaatcc ccttcctctt tctcaaagca cagtaatgtg gcactgagcc ctacccagca   2400

cctcagtgaa gggggcctgc ttgctcttta ttttggtccc ggatcctggg gtggggcaga   2460

aatattttct gggctggggt aggaggaagg ttgttgcagc catctactgc tgctgtaccc   2520

taggaatatg gggacatgga catggtgtcc catgcccaga tgataaacac tgagctgcca   2580

aaacattttt ttaaatacac ccgaggagcc caagggggaa gggcaatgcc tacccccagc   2640

gttatttttg gggagggagg gctgtgcata gggacatatt ctttagaatc tattttatta   2700

actgacctgt tttgggacct gttacccaaa taaaagatgt ttctagacat ctgtacagta   2760


<210>  807
<211>  324
<212>  PRT
<213>  Homo sapiens

<400>  807


Met Gly Pro Trp Gly Glu Pro Glu Leu Leu Val Trp Arg Pro Glu Ala 
1               5                   10                  15      


Val Ala Ser Glu Pro Pro Val Pro Val Gly Leu Glu Val Lys Leu Gly 
            20                  25                  30          


Ala Leu Val Leu Leu Leu Val Leu Thr Leu Leu Cys Ser Leu Val Pro 
        35                  40                  45              


Ile Cys Val Leu Arg Arg Pro Gly Ala Asn His Glu Gly Ser Ala Ser 
    50                  55                  60                  


Arg Gln Lys Ala Leu Ser Leu Val Ser Cys Phe Ala Gly Gly Val Phe 
65                  70                  75                  80  


Leu Ala Thr Cys Leu Leu Asp Leu Leu Pro Asp Tyr Leu Ala Ala Ile 
                85                  90                  95      


Asp Glu Ala Leu Ala Ala Leu His Val Thr Leu Gln Phe Pro Leu Gln 
            100                 105                 110         


Glu Phe Ile Leu Ala Met Gly Phe Phe Leu Val Leu Val Met Glu Gln 
        115                 120                 125             


Ile Thr Leu Ala Tyr Lys Glu Gln Ser Gly Pro Ser Pro Leu Glu Glu 
    130                 135                 140                 


Thr Arg Ala Leu Leu Gly Thr Val Asn Gly Gly Pro Gln His Trp His 
145                 150                 155                 160 


Asp Gly Pro Gly Val Pro Gln Ala Ser Gly Ala Pro Ala Thr Pro Ser 
                165                 170                 175     


Ala Leu Arg Ala Cys Val Leu Val Phe Ser Leu Ala Leu His Ser Val 
            180                 185                 190         


Phe Glu Gly Leu Ala Val Gly Leu Gln Arg Asp Arg Ala Arg Ala Met 
        195                 200                 205             


Glu Leu Cys Leu Ala Leu Leu Leu His Lys Gly Ile Leu Ala Val Ser 
    210                 215                 220                 


Leu Ser Leu Arg Leu Leu Gln Ser His Leu Arg Ala Gln Val Val Ala 
225                 230                 235                 240 


Gly Cys Gly Ile Leu Phe Ser Cys Met Thr Pro Leu Gly Ile Gly Leu 
                245                 250                 255     


Gly Ala Ala Leu Ala Glu Ser Ala Gly Pro Leu His Gln Leu Ala Gln 
            260                 265                 270         


Ser Val Leu Glu Gly Met Ala Ala Gly Thr Phe Leu Tyr Ile Thr Phe 
        275                 280                 285             


Leu Glu Ile Leu Pro Gln Glu Leu Ala Ser Ser Glu Gln Arg Ile Leu 
    290                 295                 300                 


Lys Val Ile Leu Leu Leu Ala Gly Phe Ala Leu Leu Thr Gly Leu Leu 
305                 310                 315                 320 


Phe Ile Gln Ile 
                

<210>  808
<211>  1943
<212>  DNA
<213>  Homo sapiens

<400>  808
aattcccgac tctaggccgg aagcgcgcgg agaccatgta gtgagaccct cgcgaggtct     60

gagagtcact ggagctacca gaagcatcat ggggccctgg ggagagccag agctcctgtg    120

tgctgcgccg gccaggagct aaccatgaag gctcagcttc ccgccagaaa gccctgagcc    180

tagtaagctg tttcgcgggg ggcgtctttt tggccacttg tctcctggac ctgctgcctg    240

actacctggc tgccatagat gaggccctgg cagccttgca cgtgacgctc cagttcccac    300

tgcaagagtt catcctggcc atgggcttct tcctggtcct ggtgatggag cagatcacac    360

tggcttacaa ggagcagtca gggccgtcac ctctggagga aacaagggct ctgctgggaa    420

cagtgaatgg tgggccgcag cattggcatg atgggccagg ggtcccacag gcgagtggag    480

ccccagcaac cccctcagcc ttgcgtgcct gtgtactggt gttctccctg gccctccact    540

ccgtgttcga ggggctggcg gtagggctgc agcgagaccg ggctcgggcc atggagctgt    600

gcctggcttt gctgctccac aagggcatcc tggctgtcag cctgtccctg cggctgttgc    660

agagccacct tagggcacag gtggtggctg gctgtgggat cctcttctca tgcatgacac    720

ctctaggcat cgggctgggt gcagctctgg cagagtcggc aggacctctg caccagctgg    780

cccagtctgt gctagagggc atggcagctg gcacctttct ctatatcacc tttctggaaa    840

tcctgcccca ggagctggcc agttctgagc aaaggatcct caaggtcatt ctgctcctag    900

caggctttgc cctgctcact ggcctgctct tcatccaaat ctagggggct tcaagagagg    960

ggcaggggag attgatgatc aggtgcccct gttctccctt ccctccccca gttgtgggga   1020

ataggaagga aaggggaagg gaaatactga ggaccaaaaa gttctctggg agctaaagat   1080

agagcctttg gggctatctg actaatgaga gggaagtggg cagacaagag gctggcccca   1140

gtcccaagga acaagagatg gtcaagtcgc tagagacata tcaggggaca ttaggattgg   1200

ggaagacact tgactgctag aatcagaggt tggacactat acataaggac aggctcacat   1260

gggaggctgg aggtgggtac ccagctgctg tggaacgggt atggacaggt cataaaccta   1320

gagtcagtgt cctgttggtc ctagcccatt tcagcaccct gccacttgga gtggacccct   1380

cctactcttc ttagcgccta ccctcatacc tatctccctc ctcccatctc ctaggggact   1440

ggcgccaaat ggtctctccc tgccaatttt ggtatcttct ctggcctctc cagtcctgct   1500

tactcctcta tttttaaagt gccaaacaaa tccccttcct ctttctcaaa gcacagtaat   1560

gtggcactga gccctaccca gcacctcagt gaagggggcc tgcttgctct ttattttggt   1620

cccggatcct ggggtggggc agaaatattt tctgggctgg ggtaggagga aggttgttgc   1680

agccatctac tgctgctgta ccctaggaat atggggacat ggacatggtg tcccatgccc   1740

agatgataaa cactgagctg ccaaaacatt tttttaaata cacccgagga gcccaagggg   1800

gaagggcaat gcctaccccc agcgttattt ttggggaggg agggctgtgc atagggacat   1860

attctttaga atctatttta ttaactgacc tgttttggga cctgttaccc aaataaaaga   1920

tgtttctaga catctgtaca gta                                           1943


<210>  809
<211>  207
<212>  PRT
<213>  Homo sapiens

<400>  809


Met Gly Phe Phe Leu Val Leu Val Met Glu Gln Ile Thr Leu Ala Tyr 
1               5                   10                  15      


Lys Glu Gln Ser Gly Pro Ser Pro Leu Glu Glu Thr Arg Ala Leu Leu 
            20                  25                  30          


Gly Thr Val Asn Gly Gly Pro Gln His Trp His Asp Gly Pro Gly Val 
        35                  40                  45              


Pro Gln Ala Ser Gly Ala Pro Ala Thr Pro Ser Ala Leu Arg Ala Cys 
    50                  55                  60                  


Val Leu Val Phe Ser Leu Ala Leu His Ser Val Phe Glu Gly Leu Ala 
65                  70                  75                  80  


Val Gly Leu Gln Arg Asp Arg Ala Arg Ala Met Glu Leu Cys Leu Ala 
                85                  90                  95      


Leu Leu Leu His Lys Gly Ile Leu Ala Val Ser Leu Ser Leu Arg Leu 
            100                 105                 110         


Leu Gln Ser His Leu Arg Ala Gln Val Val Ala Gly Cys Gly Ile Leu 
        115                 120                 125             


Phe Ser Cys Met Thr Pro Leu Gly Ile Gly Leu Gly Ala Ala Leu Ala 
    130                 135                 140                 


Glu Ser Ala Gly Pro Leu His Gln Leu Ala Gln Ser Val Leu Glu Gly 
145                 150                 155                 160 


Met Ala Ala Gly Thr Phe Leu Tyr Ile Thr Phe Leu Glu Ile Leu Pro 
                165                 170                 175     


Gln Glu Leu Ala Ser Ser Glu Gln Arg Ile Leu Lys Val Ile Leu Leu 
            180                 185                 190         


Leu Ala Gly Phe Ala Leu Leu Thr Gly Leu Leu Phe Ile Gln Ile 
        195                 200                 205         

<210>  810
<211>  1874
<212>  DNA
<213>  Homo sapiens

<400>  810
atgggagggg gcgggaattc ccgactctag gccggaagcg cgcggagacc atgtagtgag     60

accctcgcga ggtctgagag tcactggagc taccagaaaa agccctgagc ctagtaagct    120

gtttcgcggg gggcgtcttt ttggccactt gtctcctgga cctgctgcct gactacctgg    180

ctgccataga tgaggccctg gcagccttgc acgtgacgct ccagttccca ctgcaagagt    240

tcatcctggc catgggcttc ttcctggtcc tggtgatgga gcagatcaca ctggcttaca    300

aggagcagtc agggccgtca cctctggagg aaacaagggc tctgctggga acagtgaatg    360

gtgggccgca gcattggcat gatgggccag gggtcccaca ggcgagtgga gccccagcaa    420

ccccctcagc cttgcgtgcc tgtgtactgg tgttctccct ggccctccac tccgtgttcg    480

aggggctggc ggtagggctg cagcgagacc gggctcgggc catggagctg tgcctggctt    540

tgctgctcca caagggcatc ctggctgtca gcctgtccct gcggctgttg cagagccacc    600

ttagggcaca ggtggtggct ggctgtggga tcctcttctc atgcatgaca cctctaggca    660

tcgggctggg tgcagctctg gcagagtcgg caggacctct gcaccagctg gcccagtctg    720

tgctagaggg catggcagct ggcacctttc tctatatcac ctttctggaa atcctgcccc    780

aggagctggc cagttctgag caaaggatcc tcaaggtcat tctgctccta gcaggctttg    840

ccctgctcac tggcctgctc ttcatccaaa tctagggggc ttcaagagag gggcagggga    900

gattgatgat caggtgcccc tgttctccct tccctccccc agttgtgggg aataggaagg    960

aaaggggaag ggaaatactg aggaccaaaa agttctctgg gagctaaaga tagagccttt   1020

ggggctatct gactaatgag agggaagtgg gcagacaaga ggctggcccc agtcccaagg   1080

aacaagagat ggtcaagtcg ctagagacat atcaggggac attaggattg gggaagacac   1140

ttgactgcta gaatcagagg ttggacacta tacataagga caggctcaca tgggaggctg   1200

gaggtgggta cccagctgct gtggaacggg tatggacagg tcataaacct agagtcagtg   1260

tcctgttggt cctagcccat ttcagcaccc tgccacttgg agtggacccc tcctactctt   1320

cttagcgcct accctcatac ctatctccct cctcccatct cctaggggac tggcgccaaa   1380

tggtctctcc ctgccaattt tggtatcttc tctggcctct ccagtcctgc ttactcctct   1440

atttttaaag tgccaaacaa atccccttcc tctttctcaa agcacagtaa tgtggcactg   1500

agccctaccc agcacctcag tgaagggggc ctgcttgctc tttattttgg tcccggatcc   1560

tggggtgggg cagaaatatt ttctgggctg gggtaggagg aaggttgttg cagccatcta   1620

ctgctgctgt accctaggaa tatggggaca tggacatggt gtcccatgcc cagatgataa   1680

acactgagct gccaaaacat ttttttaaat acacccgagg agcccaaggg ggaagggcaa   1740

tgcctacccc cagcgttatt tttggggagg gagggctgtg catagggaca tattctttag   1800

aatctatttt attaactgac ctgttttggg acctgttacc caaataaaag atgtttctag   1860

acatctgtac agta                                                     1874


<210>  811
<211>  207
<212>  PRT
<213>  Homo sapiens

<400>  811


Met Gly Phe Phe Leu Val Leu Val Met Glu Gln Ile Thr Leu Ala Tyr 
1               5                   10                  15      


Lys Glu Gln Ser Gly Pro Ser Pro Leu Glu Glu Thr Arg Ala Leu Leu 
            20                  25                  30          


Gly Thr Val Asn Gly Gly Pro Gln His Trp His Asp Gly Pro Gly Val 
        35                  40                  45              


Pro Gln Ala Ser Gly Ala Pro Ala Thr Pro Ser Ala Leu Arg Ala Cys 
    50                  55                  60                  


Val Leu Val Phe Ser Leu Ala Leu His Ser Val Phe Glu Gly Leu Ala 
65                  70                  75                  80  


Val Gly Leu Gln Arg Asp Arg Ala Arg Ala Met Glu Leu Cys Leu Ala 
                85                  90                  95      


Leu Leu Leu His Lys Gly Ile Leu Ala Val Ser Leu Ser Leu Arg Leu 
            100                 105                 110         


Leu Gln Ser His Leu Arg Ala Gln Val Val Ala Gly Cys Gly Ile Leu 
        115                 120                 125             


Phe Ser Cys Met Thr Pro Leu Gly Ile Gly Leu Gly Ala Ala Leu Ala 
    130                 135                 140                 


Glu Ser Ala Gly Pro Leu His Gln Leu Ala Gln Ser Val Leu Glu Gly 
145                 150                 155                 160 


Met Ala Ala Gly Thr Phe Leu Tyr Ile Thr Phe Leu Glu Ile Leu Pro 
                165                 170                 175     


Gln Glu Leu Ala Ser Ser Glu Gln Arg Ile Leu Lys Val Ile Leu Leu 
            180                 185                 190         


Leu Ala Gly Phe Ala Leu Leu Thr Gly Leu Leu Phe Ile Gln Ile 
        195                 200                 205         

<210>  812
<211>  2084
<212>  DNA
<213>  Homo sapiens

<400>  812
gggagctatg ggagggggcg ggaattcccg actctaggcc ggaagcgcgc ggagaccatg     60

tagtgagacc ctcgcgaggt ctgagagtca ctggagctac cagaagcatc atggggccct    120

ggggagagcc agagctcctg gtgtggcgcc ccgaggcggt agcttcagag cctccagtgc    180

ctgtggggct ggaggtgaag ttgggggccc tggtgctgct gctggtgctc accctcctct    240

gcagcctggt gcccatctgt gtgctgcgcc ggccaggagc taaccatgaa ggctcagctt    300

cccgccagaa agccctgagc ctagtaagct gtttcgcggg gggcgtcttt ttggccactt    360

gtctcctgga cctgctgcct gactacctgg ctgccataga tgaggccctg gcagccttgc    420

acgtgacgct ccagttccca ctgcaagagt tcatcctggc catgggcttc ttcctggtcc    480

tggtgatgga gcagatcaca ctggcttaca aggagcagtc agggccgtca cctctggagg    540

aaacaagggc tctgctggga acagtgaatg gtgggccgca gcattggcat gatgggccag    600

gggtcccaca ggcgagtgga gccccagcaa ccccctcagc cttgcgtgcc tgtgtactgg    660

tgttctccct ggccctccac tccgtgttcg aggggctggc ggtagggctg cagcgagacc    720

gggctcgggc catggagctg tgcctggctt tgctgctcca caagggcatc ctggctgtca    780

gcctgtccct gcggctgttg cagagccacc ttagggcaca ggtggtggct ggctgtggga    840

tcctcttctc atgcatgaca cctctaggca tcgggctggg tgcagctctg gcagagtcgg    900

caggacctct gcaccagctg gcccagtctg tgctagaggg catggcagct ggcacctttc    960

tctatatcac ctttctggaa atcctgcccc aggagctggc cagttctgag caaaggatcc   1020

tcaaggtcat tctgctccta gcaggctttg ccctgctcac tggcctgctc ttcatccaaa   1080

tctagggggc ttcaagagag gggcagggga gattgatgat caggtgcccc tgttctccct   1140

tccctccccc agttgtgggg aataggaagg aaaggggaag ggaaatactg aggaccaaaa   1200

agttctctgg gagctaaaga tagagccttt ggggctatct gactaatgag agggaagtgg   1260

gcagacaaga ggctggcccc agtcccaagg aacaagagat ggtcaagtcg ctagagacat   1320

atcaggggac attaggattg gggaagacac ttgactgcta gaatcagagg ttggacacta   1380

tacataagga caggctcaca tgggaggctg gaggtgggta cccagctgct gtggaacggg   1440

tatggacagg tcataaacct agagtcagtg tcctgttggt cctagcccat ttcagcaccc   1500

tgccacttgg agtggacccc tcctactctt cttagcgcct accctcatac ctatctccct   1560

cctcccatct cctaggggac tggcgccaaa tggtctctcc ctgccaattt tggtatcttc   1620

tctggcctct ccagtcctgc ttactcctct atttttaaag tgccaaacaa atccccttcc   1680

tctttctcaa agcacagtaa tgtggcactg agccctaccc agcacctcag tgaagggggc   1740

ctgcttgctc tttattttgg tcccggatcc tggggtgggg cagaaatatt ttctgggctg   1800

gggtaggagg aaggttgttg cagccatcta ctgctgctgt accctaggaa tatggggaca   1860

tggacatggt gtcccatgcc cagatgataa acactgagct gccaaaacat ttttttaaat   1920

acacccgagg agcccaaggg ggaagggcaa tgcctacccc cagcgttatt tttggggagg   1980

gagggctgtg catagggaca tattctttag aatctatttt attaactgac ctgttttggg   2040

acctgttacc caaataaaag atgtttctag acatctgtac agta                    2084


<210>  813
<211>  324
<212>  PRT
<213>  Homo sapiens

<400>  813


Met Gly Pro Trp Gly Glu Pro Glu Leu Leu Val Trp Arg Pro Glu Ala 
1               5                   10                  15      


Val Ala Ser Glu Pro Pro Val Pro Val Gly Leu Glu Val Lys Leu Gly 
            20                  25                  30          


Ala Leu Val Leu Leu Leu Val Leu Thr Leu Leu Cys Ser Leu Val Pro 
        35                  40                  45              


Ile Cys Val Leu Arg Arg Pro Gly Ala Asn His Glu Gly Ser Ala Ser 
    50                  55                  60                  


Arg Gln Lys Ala Leu Ser Leu Val Ser Cys Phe Ala Gly Gly Val Phe 
65                  70                  75                  80  


Leu Ala Thr Cys Leu Leu Asp Leu Leu Pro Asp Tyr Leu Ala Ala Ile 
                85                  90                  95      


Asp Glu Ala Leu Ala Ala Leu His Val Thr Leu Gln Phe Pro Leu Gln 
            100                 105                 110         


Glu Phe Ile Leu Ala Met Gly Phe Phe Leu Val Leu Val Met Glu Gln 
        115                 120                 125             


Ile Thr Leu Ala Tyr Lys Glu Gln Ser Gly Pro Ser Pro Leu Glu Glu 
    130                 135                 140                 


Thr Arg Ala Leu Leu Gly Thr Val Asn Gly Gly Pro Gln His Trp His 
145                 150                 155                 160 


Asp Gly Pro Gly Val Pro Gln Ala Ser Gly Ala Pro Ala Thr Pro Ser 
                165                 170                 175     


Ala Leu Arg Ala Cys Val Leu Val Phe Ser Leu Ala Leu His Ser Val 
            180                 185                 190         


Phe Glu Gly Leu Ala Val Gly Leu Gln Arg Asp Arg Ala Arg Ala Met 
        195                 200                 205             


Glu Leu Cys Leu Ala Leu Leu Leu His Lys Gly Ile Leu Ala Val Ser 
    210                 215                 220                 


Leu Ser Leu Arg Leu Leu Gln Ser His Leu Arg Ala Gln Val Val Ala 
225                 230                 235                 240 


Gly Cys Gly Ile Leu Phe Ser Cys Met Thr Pro Leu Gly Ile Gly Leu 
                245                 250                 255     


Gly Ala Ala Leu Ala Glu Ser Ala Gly Pro Leu His Gln Leu Ala Gln 
            260                 265                 270         


Ser Val Leu Glu Gly Met Ala Ala Gly Thr Phe Leu Tyr Ile Thr Phe 
        275                 280                 285             


Leu Glu Ile Leu Pro Gln Glu Leu Ala Ser Ser Glu Gln Arg Ile Leu 
    290                 295                 300                 


Lys Val Ile Leu Leu Leu Ala Gly Phe Ala Leu Leu Thr Gly Leu Leu 
305                 310                 315                 320 


Phe Ile Gln Ile 
                

<210>  814
<211>  2284
<212>  DNA
<213>  Homo sapiens

<400>  814
ggagtgcggt ggtgcgatca cggttccatg cagcccccga cctcccgggc tcaggtgatt     60

ctcccgcctc agcaccgcga gcagctagga ccacaggcgc gagccactgc gtccggccgg    120

cgggacttat ttgtcaggcg gggattgggt tccgccagcc taaagggagg ggtcgcctgc    180

tccgcccgct cccgctcccg atctctgatt gctcctaact gacgtcactc ccggtctgtc    240

cccgcccact cggtgctgcc attggcagtc ggtcgtgggt ctgagagtca ctggagctac    300

cagaagcatc atggggccct ggggagagcc agagctcctg gtgtggcgcc ccgaggcggt    360

agcttcagag cctccagtgc ctgtggggct ggaggtgaag ttgggggccc tggtgctgct    420

gctggtgctc accctcctct gcagcctggt gcccatctgt gtgctgcgcc ggccaggagc    480

taaccatgaa ggctcagctt cccgccagaa agccctgagc ctagtaagct gtttcgcggg    540

gggcgtcttt ttggccactt gtctcctgga cctgctgcct gactacctgg ctgccataga    600

tgaggccctg gcagccttgc acgtgacgct ccagttccca ctgcaagagt tcatcctggc    660

catgggcttc ttcctggtcc tggtgatgga gcagatcaca ctggcttaca aggagcagtc    720

agggccgtca cctctggagg aaacaagggc tctgctggga acagtgaatg gtgggccgca    780

gcattggcat gatgggccag gggtcccaca ggcgagtgga gccccagcaa ccccctcagc    840

cttgcgtgcc tgtgtactgg tgttctccct ggccctccac tccgtgttcg aggggctggc    900

ggtagggctg cagcgagacc gggctcgggc catggagctg tgcctggctt tgctgctcca    960

caagggcatc ctggctgtca gcctgtccct gcggctgttg cagagccacc ttagggcaca   1020

ggtggtggct ggctgtggga tcctcttctc atgcatgaca cctctaggca tcgggctggg   1080

tgcagctctg gcagagtcgg caggacctct gcaccagctg gcccagtctg tgctagaggg   1140

catggcagct ggcacctttc tctatatcac ctttctggaa atcctgcccc aggagctggc   1200

cagttctgag caaaggatcc tcaaggtcat tctgctccta gcaggctttg ccctgctcac   1260

tggcctgctc ttcatccaaa tctagggggc ttcaagagag gggcagggga gattgatgat   1320

caggtgcccc tgttctccct tccctccccc agttgtgggg aataggaagg aaaggggaag   1380

ggaaatactg aggaccaaaa agttctctgg gagctaaaga tagagccttt ggggctatct   1440

gactaatgag agggaagtgg gcagacaaga ggctggcccc agtcccaagg aacaagagat   1500

ggtcaagtcg ctagagacat atcaggggac attaggattg gggaagacac ttgactgcta   1560

gaatcagagg ttggacacta tacataagga caggctcaca tgggaggctg gaggtgggta   1620

cccagctgct gtggaacggg tatggacagg tcataaacct agagtcagtg tcctgttggt   1680

cctagcccat ttcagcaccc tgccacttgg agtggacccc tcctactctt cttagcgcct   1740

accctcatac ctatctccct cctcccatct cctaggggac tggcgccaaa tggtctctcc   1800

ctgccaattt tggtatcttc tctggcctct ccagtcctgc ttactcctct atttttaaag   1860

tgccaaacaa atccccttcc tctttctcaa agcacagtaa tgtggcactg agccctaccc   1920

agcacctcag tgaagggggc ctgcttgctc tttattttgg tcccggatcc tggggtgggg   1980

cagaaatatt ttctgggctg gggtaggagg aaggttgttg cagccatcta ctgctgctgt   2040

accctaggaa tatggggaca tggacatggt gtcccatgcc cagatgataa acactgagct   2100

gccaaaacat ttttttaaat acacccgagg agcccaaggg ggaagggcaa tgcctacccc   2160

cagcgttatt tttggggagg gagggctgtg catagggaca tattctttag aatctatttt   2220

attaactgac ctgttttggg acctgttacc caaataaaag atgtttctag acatctgtac   2280

agta                                                                2284


<210>  815
<211>  324
<212>  PRT
<213>  Homo sapiens

<400>  815


Met Gly Pro Trp Gly Glu Pro Glu Leu Leu Val Trp Arg Pro Glu Ala 
1               5                   10                  15      


Val Ala Ser Glu Pro Pro Val Pro Val Gly Leu Glu Val Lys Leu Gly 
            20                  25                  30          


Ala Leu Val Leu Leu Leu Val Leu Thr Leu Leu Cys Ser Leu Val Pro 
        35                  40                  45              


Ile Cys Val Leu Arg Arg Pro Gly Ala Asn His Glu Gly Ser Ala Ser 
    50                  55                  60                  


Arg Gln Lys Ala Leu Ser Leu Val Ser Cys Phe Ala Gly Gly Val Phe 
65                  70                  75                  80  


Leu Ala Thr Cys Leu Leu Asp Leu Leu Pro Asp Tyr Leu Ala Ala Ile 
                85                  90                  95      


Asp Glu Ala Leu Ala Ala Leu His Val Thr Leu Gln Phe Pro Leu Gln 
            100                 105                 110         


Glu Phe Ile Leu Ala Met Gly Phe Phe Leu Val Leu Val Met Glu Gln 
        115                 120                 125             


Ile Thr Leu Ala Tyr Lys Glu Gln Ser Gly Pro Ser Pro Leu Glu Glu 
    130                 135                 140                 


Thr Arg Ala Leu Leu Gly Thr Val Asn Gly Gly Pro Gln His Trp His 
145                 150                 155                 160 


Asp Gly Pro Gly Val Pro Gln Ala Ser Gly Ala Pro Ala Thr Pro Ser 
                165                 170                 175     


Ala Leu Arg Ala Cys Val Leu Val Phe Ser Leu Ala Leu His Ser Val 
            180                 185                 190         


Phe Glu Gly Leu Ala Val Gly Leu Gln Arg Asp Arg Ala Arg Ala Met 
        195                 200                 205             


Glu Leu Cys Leu Ala Leu Leu Leu His Lys Gly Ile Leu Ala Val Ser 
    210                 215                 220                 


Leu Ser Leu Arg Leu Leu Gln Ser His Leu Arg Ala Gln Val Val Ala 
225                 230                 235                 240 


Gly Cys Gly Ile Leu Phe Ser Cys Met Thr Pro Leu Gly Ile Gly Leu 
                245                 250                 255     


Gly Ala Ala Leu Ala Glu Ser Ala Gly Pro Leu His Gln Leu Ala Gln 
            260                 265                 270         


Ser Val Leu Glu Gly Met Ala Ala Gly Thr Phe Leu Tyr Ile Thr Phe 
        275                 280                 285             


Leu Glu Ile Leu Pro Gln Glu Leu Ala Ser Ser Glu Gln Arg Ile Leu 
    290                 295                 300                 


Lys Val Ile Leu Leu Leu Ala Gly Phe Ala Leu Leu Thr Gly Leu Leu 
305                 310                 315                 320 


Phe Ile Gln Ile 
                

<210>  816
<211>  2440
<212>  DNA
<213>  Homo sapiens

<400>  816
aggagagtca ggccaatggg gccgcagttc tttctttttt ttttctttat tcttattttt     60

ggagacaggg tctcgctctg ttgcccaggc tggagtgcgg tggtgcgatc acggttccat    120

gcagcccccg acctcccggg ctcaggtgat tctcccgcct cagcaccgcg agcagctagg    180

accacaggcg cgagccactg cgtccggccg gcgggactta tttgtcaggc ggggattggg    240

ttccgccagc ctaaagggag gggtaagcgc cagaatatga atcgccggga agctgggaga    300

aagctccggg aaaccctgag cagccaggtc gcctgctccg cccgctcccg ctcccgatct    360

ctgattgctc ctaactgacg tcactcccgg tctgtccccg cccactcggt gctgccattg    420

gcagtcggtc gtgggtctga gagtcactgg agctaccaga agcatcatgg ggccctgggg    480

agagccagag ctcctggtgt ggcgccccga ggcggtagct tcagagcctc cagtgcctgt    540

ggggctggag gtgaagttgg gggccctggt gctgctgctg gtgctcaccc tcctctgcag    600

cctggtgccc atctgtgtgc tgcgccggcc aggagctaac catgaaggct cagcttcccg    660

ccagaaagcc ctgagcctag taagctgttt cgcggggggc gtctttttgg ccacttgtct    720

cctggacctg ctgcctgact acctggctgc catagatgag gccctggcag ccttgcacgt    780

gacgctccag ttcccactgc aagagttcat cctggccatg ggcttcttcc tggtcctggt    840

gatggagcag atcacactgg cttacaagga gcagtcaggg ccgtcacctc tggaggaaac    900

aagggctctg ctgggaacag tgaatggtgg gccgcagcat tggcatgatg ggccaggggt    960

cccacaggcg agtggagccc cagcaacccc ctcagccttg cgtgcctgtg tactggtgtt   1020

ctccctggcc ctccactccg tgttcgaggg gctggcggta gggctgcagc gagaccgggc   1080

tcgggccatg gagctgtgcc tggctttgct gctccacaag ggcatcctgg ctgtcagcct   1140

gtccctgcgg ctgttgcaga gccaccttag ggcacaggtg gtggctggct gtgggatcct   1200

cttctcatgc atgacacctc taggcatcgg gctgggtgca gctctggcag agtcggcagg   1260

acctctgcac cagctggccc agtctgtgct agagggcatg gcagctggca cctttctcta   1320

tatcaccttt ctggaaatcc tgccccagga gctggccagt tctgagcaaa ggatcctcaa   1380

ggtcattctg ctcctagcag gctttgccct gctcactggc ctgctcttca tccaaatcta   1440

gggggcttca agagaggggc aggggagatt gatgatcagg tgcccctgtt ctcccttccc   1500

tcccccagtt gtggggaata ggaaggaaag gggaagggaa atactgagga ccaaaaagtt   1560

ctctgggagc taaagataga gcctttgggg ctatctgact aatgagaggg aagtgggcag   1620

acaagaggct ggccccagtc ccaaggaaca agagatggtc aagtcgctag agacatatca   1680

ggggacatta ggattgggga agacacttga ctgctagaat cagaggttgg acactataca   1740

taaggacagg ctcacatggg aggctggagg tgggtaccca gctgctgtgg aacgggtatg   1800

gacaggtcat aaacctagag tcagtgtcct gttggtccta gcccatttca gcaccctgcc   1860

acttggagtg gacccctcct actcttctta gcgcctaccc tcatacctat ctccctcctc   1920

ccatctccta ggggactggc gccaaatggt ctctccctgc caattttggt atcttctctg   1980

gcctctccag tcctgcttac tcctctattt ttaaagtgcc aaacaaatcc ccttcctctt   2040

tctcaaagca cagtaatgtg gcactgagcc ctacccagca cctcagtgaa gggggcctgc   2100

ttgctcttta ttttggtccc ggatcctggg gtggggcaga aatattttct gggctggggt   2160

aggaggaagg ttgttgcagc catctactgc tgctgtaccc taggaatatg gggacatgga   2220

catggtgtcc catgcccaga tgataaacac tgagctgcca aaacattttt ttaaatacac   2280

ccgaggagcc caagggggaa gggcaatgcc tacccccagc gttatttttg gggagggagg   2340

gctgtgcata gggacatatt ctttagaatc tattttatta actgacctgt tttgggacct   2400

gttacccaaa taaaagatgt ttctagacat ctgtacagta                         2440


<210>  817
<211>  324
<212>  PRT
<213>  Homo sapiens

<400>  817


Met Gly Pro Trp Gly Glu Pro Glu Leu Leu Val Trp Arg Pro Glu Ala 
1               5                   10                  15      


Val Ala Ser Glu Pro Pro Val Pro Val Gly Leu Glu Val Lys Leu Gly 
            20                  25                  30          


Ala Leu Val Leu Leu Leu Val Leu Thr Leu Leu Cys Ser Leu Val Pro 
        35                  40                  45              


Ile Cys Val Leu Arg Arg Pro Gly Ala Asn His Glu Gly Ser Ala Ser 
    50                  55                  60                  


Arg Gln Lys Ala Leu Ser Leu Val Ser Cys Phe Ala Gly Gly Val Phe 
65                  70                  75                  80  


Leu Ala Thr Cys Leu Leu Asp Leu Leu Pro Asp Tyr Leu Ala Ala Ile 
                85                  90                  95      


Asp Glu Ala Leu Ala Ala Leu His Val Thr Leu Gln Phe Pro Leu Gln 
            100                 105                 110         


Glu Phe Ile Leu Ala Met Gly Phe Phe Leu Val Leu Val Met Glu Gln 
        115                 120                 125             


Ile Thr Leu Ala Tyr Lys Glu Gln Ser Gly Pro Ser Pro Leu Glu Glu 
    130                 135                 140                 


Thr Arg Ala Leu Leu Gly Thr Val Asn Gly Gly Pro Gln His Trp His 
145                 150                 155                 160 


Asp Gly Pro Gly Val Pro Gln Ala Ser Gly Ala Pro Ala Thr Pro Ser 
                165                 170                 175     


Ala Leu Arg Ala Cys Val Leu Val Phe Ser Leu Ala Leu His Ser Val 
            180                 185                 190         


Phe Glu Gly Leu Ala Val Gly Leu Gln Arg Asp Arg Ala Arg Ala Met 
        195                 200                 205             


Glu Leu Cys Leu Ala Leu Leu Leu His Lys Gly Ile Leu Ala Val Ser 
    210                 215                 220                 


Leu Ser Leu Arg Leu Leu Gln Ser His Leu Arg Ala Gln Val Val Ala 
225                 230                 235                 240 


Gly Cys Gly Ile Leu Phe Ser Cys Met Thr Pro Leu Gly Ile Gly Leu 
                245                 250                 255     


Gly Ala Ala Leu Ala Glu Ser Ala Gly Pro Leu His Gln Leu Ala Gln 
            260                 265                 270         


Ser Val Leu Glu Gly Met Ala Ala Gly Thr Phe Leu Tyr Ile Thr Phe 
        275                 280                 285             


Leu Glu Ile Leu Pro Gln Glu Leu Ala Ser Ser Glu Gln Arg Ile Leu 
    290                 295                 300                 


Lys Val Ile Leu Leu Leu Ala Gly Phe Ala Leu Leu Thr Gly Leu Leu 
305                 310                 315                 320 


Phe Ile Gln Ile 
                

<210>  818
<211>  896
<212>  DNA
<213>  Homo sapiens

<400>  818
accgtttcct caacctggat tcttgtggcc cacaactctg tgccttgaga atcctcttct     60

agcctcaagg gacggtaaga caaaagaaaa tttaaaaagg gggctcagct gttcttttat    120

gcaaaggtga aaaaagcttc attgcctaaa gaagggacag atgggatctt gcttcctaca    180

ggaaaattaa ttttaaaaaa gaaaaaaaaa aggggggaca gtgtaatgct tctcacaagg    240

ctccagaaac gaagcccagt aattccttaa gtaaaagagg aatgtgaaga cttcttaagg    300

ggccgggcgc ggtggttcac gcctgtaatc caagcacttt ggaaggccga ggatgaatca    360

cctgaggaca gaagttcaag accagcctgg tcaacatggt gaaaccccgt ctctactaaa    420

tatacaaaaa ttagccgggc gtggtggcgg gggcctgtaa tcccagctac tcgggaggcc    480

gaggcaggag aatcgcttga acccgggagc cggaaattgc agtgagccga gatcgcgcca    540

ttgcgctcca gcctgggcaa caacagcgaa acttcgtctc aaaaaaaaaa attattcgta    600

attggtaaca ttaacaagga attatgactg ggggggtcag gaaacctgga ttctggtcca    660

agttctacct ttatagttgt caaatatata tatttgttta tttatacaca tacatatgtc    720

atatatgatc aatagatctc caacggaagc taactacatt ccccactcaa atcatctctg    780

cacatacagc ccgcaggaag ccctttgaaa tgtatttaac cacctttctc gctctcagaa    840

tgatctcaac aagaacagct ttgctttcct tggagctctg catcaatcta ggaagg        896


<210>  819
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  819


Met Ser Tyr Met Ile Asn Arg Ser Pro Thr Glu Ala Asn Tyr Ile Pro 
1               5                   10                  15      


His Ser Asn His Leu Cys Thr Tyr Ser Pro Gln Glu Ala Leu 
            20                  25                  30  

<210>  820
<211>  1973
<212>  DNA
<213>  Homo sapiens

<400>  820
agaactgcgg ccccattggc ctgactctcc tgaacagcca aactgtctcc gaccagttac     60

ggaagaggcg gccttgagag ggtagtgtgc cattggctcg atgtcctgcc cctccgaaac    120

ctaagtcttc agcttccaat caggactcag ctttgggaag agcgccacgc ggtgggcgag    180

gggatgccct agtaaattcg caggtctctt gactctttcc gcctttgttt acaaccctgc    240

catgatctcc ctcttgcaaa agcgagggct acagaacagg cattcaggag tcctgtgctc    300

cagtcacagc cttttctgtt cttcagctag gagacaccaa accctcagga agatttacta    360

tagctaagag aaaactgcag cagaaagggc gcggctacct acttcttaaa ttccgtttgt    420

ggaccctcag actcttagtc ccctactccc agatacagcg gccctaccgt ggctcctggc    480

aagaagcatg gatctcggaa tccctgacct gctggacgcg tggctggagc ccccagagga    540

tatcttctcg acaggatccg tcctggagct gggactccac tgcccccctc cagaggttcc    600

ggtaactagg ctacaggaac agggactgca aggctggaag tccggtgggg accgtggctg    660

tggccttcaa gagagtgagc ctgaagattt cttgaagctt ttcattgatc ccaatgaggt    720

gtactgctca gaagcatctc ctggcagtga cagtggcatc tctgaggacc cctgccatcc    780

agacagtccc cctgccccca gggcaaccag ttctcctatg ctctatgagg ttgtctatga    840

ggcaggggcc ctggagagga tgcaggggga aactgggcca aatgtaggcc ttatctccat    900

ccagctagat cagtggagcc cagcatttat ggtgcctgat tcctgcatgg tcagtgagct    960

gccctttgat gctcatgccc acatcctgcc cagagcaggc accgtagccc cagtgccctg   1020

tacaaccctg ctgccctgtc aaaccctgtt cctgaccgat gaggagaagc gtctgctggg   1080

gcaggaaggg gtttccctgc cctctcacct gcccctcacc aaggcagagg agagggtcct   1140

caagaaggtc aggaggaaaa tccgtaacaa gcagtcagct caggacagtc ggcggcggaa   1200

gaaggagtac attgatgggc tggagagcag ggtggcagcc tgttctgcac agaaccaaga   1260

attacagaaa aaagtccagg agctggagag gcacaacatc tccttggtag ctcagctccg   1320

ccagctgcag acgctaattg ctcaaacttc caacaaagct gcccagacca gcacttgtgt   1380

tttgattctt cttttttccc tggctctcat catcctgccc agcttcagtc cattccagag   1440

tcgaccagaa gctgggtctg aggattacca gcctcacgga gtgacttcca gaaatatcct   1500

gacccacaag gacgtaacag aaaatctgga gacccaagtg gtagagtcca gactgaggga   1560

gccacctgga gccaaggatg caaatggctc aacaaggaca ctgcttgaga agatgggagg   1620

gaagccaaga cccagtgggc gcatccggtc cgtgctgcat gcagatgaga tgtgagctgg   1680

aacagacctt cctggcccac ttcctgatca caaggaatcc tgggcttcct tatggctttg   1740

cttcccactg ggattcctac ttaggtgtct gccctcaggg gtccaaatca cttcaggaca   1800

ccccaagaga tgtcctttag tctctgcctg aggcctagtc tgcatttgtt tgcatatatg   1860

agagggtacc tcaaatactt ctgttatgta tctgtgattt tatttcttct ttgggtatag   1920

ggttgagggg aaataagttt tgagtgagaa ataaacgttt tagctgaaat tgt          1973


<210>  821
<211>  395
<212>  PRT
<213>  Homo sapiens

<400>  821


Met Asp Leu Gly Ile Pro Asp Leu Leu Asp Ala Trp Leu Glu Pro Pro 
1               5                   10                  15      


Glu Asp Ile Phe Ser Thr Gly Ser Val Leu Glu Leu Gly Leu His Cys 
            20                  25                  30          


Pro Pro Pro Glu Val Pro Val Thr Arg Leu Gln Glu Gln Gly Leu Gln 
        35                  40                  45              


Gly Trp Lys Ser Gly Gly Asp Arg Gly Cys Gly Leu Gln Glu Ser Glu 
    50                  55                  60                  


Pro Glu Asp Phe Leu Lys Leu Phe Ile Asp Pro Asn Glu Val Tyr Cys 
65                  70                  75                  80  


Ser Glu Ala Ser Pro Gly Ser Asp Ser Gly Ile Ser Glu Asp Pro Cys 
                85                  90                  95      


His Pro Asp Ser Pro Pro Ala Pro Arg Ala Thr Ser Ser Pro Met Leu 
            100                 105                 110         


Tyr Glu Val Val Tyr Glu Ala Gly Ala Leu Glu Arg Met Gln Gly Glu 
        115                 120                 125             


Thr Gly Pro Asn Val Gly Leu Ile Ser Ile Gln Leu Asp Gln Trp Ser 
    130                 135                 140                 


Pro Ala Phe Met Val Pro Asp Ser Cys Met Val Ser Glu Leu Pro Phe 
145                 150                 155                 160 


Asp Ala His Ala His Ile Leu Pro Arg Ala Gly Thr Val Ala Pro Val 
                165                 170                 175     


Pro Cys Thr Thr Leu Leu Pro Cys Gln Thr Leu Phe Leu Thr Asp Glu 
            180                 185                 190         


Glu Lys Arg Leu Leu Gly Gln Glu Gly Val Ser Leu Pro Ser His Leu 
        195                 200                 205             


Pro Leu Thr Lys Ala Glu Glu Arg Val Leu Lys Lys Val Arg Arg Lys 
    210                 215                 220                 


Ile Arg Asn Lys Gln Ser Ala Gln Asp Ser Arg Arg Arg Lys Lys Glu 
225                 230                 235                 240 


Tyr Ile Asp Gly Leu Glu Ser Arg Val Ala Ala Cys Ser Ala Gln Asn 
                245                 250                 255     


Gln Glu Leu Gln Lys Lys Val Gln Glu Leu Glu Arg His Asn Ile Ser 
            260                 265                 270         


Leu Val Ala Gln Leu Arg Gln Leu Gln Thr Leu Ile Ala Gln Thr Ser 
        275                 280                 285             


Asn Lys Ala Ala Gln Thr Ser Thr Cys Val Leu Ile Leu Leu Phe Ser 
    290                 295                 300                 


Leu Ala Leu Ile Ile Leu Pro Ser Phe Ser Pro Phe Gln Ser Arg Pro 
305                 310                 315                 320 


Glu Ala Gly Ser Glu Asp Tyr Gln Pro His Gly Val Thr Ser Arg Asn 
                325                 330                 335     


Ile Leu Thr His Lys Asp Val Thr Glu Asn Leu Glu Thr Gln Val Val 
            340                 345                 350         


Glu Ser Arg Leu Arg Glu Pro Pro Gly Ala Lys Asp Ala Asn Gly Ser 
        355                 360                 365             


Thr Arg Thr Leu Leu Glu Lys Met Gly Gly Lys Pro Arg Pro Ser Gly 
    370                 375                 380                 


Arg Ile Arg Ser Val Leu His Ala Asp Glu Met 
385                 390                 395 

<210>  822
<211>  2757
<212>  DNA
<213>  Homo sapiens

<400>  822
agaactgcgg ccccattggc ctgactctcc tgaacagcca aactgtctcc gaccagttac     60

ggaagaggcg gccttgagag ggtagtgtgc cattggctcg atgtcctgcc cctccgaaac    120

ctaagtcttc agcttccaat caggactcag ctttgggaag agcgccacgc ggtgggcgag    180

gggatgccct agtaaattcg caggtctctt gactctttcc gcctttgttt acaaccctgc    240

catgatctcc ctcttgcaaa agcgagggct acagaacagg cattcaggag tcctgtgctc    300

cagtcacagc cttttctgtt cttcagctag gagacaccaa accctcagga agatttacta    360

tagctaagag aaaactgcag cagaaagggc gcggctacct acttcttaaa ttccgtttgt    420

ggaccctcag actcttagtc ccctactccc agatacagcg gccctaccgt ggctcctggc    480

aagaagcatg gatctcggaa tccctgacct gctggacgcg tggctggagc ccccagagga    540

tatcttctcg acaggatccg tcctggagct gggactccac tgcccccctc cagaggttcc    600

ggtaactagg ctacaggaac agggactgca aggctggaag tccggtgggg accgtggctg    660

tggccttcaa gagagtgagc ctgaagattt cttgaagctt ttcattgatc ccaatgaggt    720

gtactgctca gaagcatctc ctggcagtga cagtggcatc tctgaggacc cctgccatcc    780

agacagtccc cctgccccca gggcaaccag ttctcctatg ctctatgagg ttgtctatga    840

ggcaggggcc ctggagagga tgcaggggga aactgggcca aatgtaggcc ttatctccat    900

ccagctagat cagtggagcc cagcatttat ggtgcctgat tcctgcatgg tcagtgagct    960

gccctttgat gctcatgccc acatcctgcc cagagcaggc accgtagccc cagtgccctg   1020

tacaaccctg ctgccctgtc aaaccctgtt cctgaccgat gaggagaagc gtctgctggg   1080

gcaggaaggg gtttccctgc cctctcacct gcccctcacc aaggcagagg agagggtcct   1140

caagaaggtc aggaggaaaa tccgtaacaa gcagtcagct caggacagtc ggcggcggaa   1200

gaaggagtac attgatgggc tggagagcag ggtggcagcc tgttctgcac agaaccaaga   1260

attacagaaa aaagtccagg agctggagag gcacaacatc tccttggtag ctcagctccg   1320

ccagctgcag acgctaattg ctcaaacttc caacaaagct gcccagacca gcacttgtgt   1380

tttgattctt cttttttccc tggctctcat catcctgccc agcttcagtc cattccagag   1440

tcgaccagaa gctgggtctg aggattacca gcctcacgga gtgacttcca gaaatatcct   1500

gacccacaag gacgtaacag aaaatctgga gacccaagtg gtagagtcca gactgaggga   1560

gccacctgga gccaaggatg caaatggctc aacaaggaca ctgcttgaga agatgggagg   1620

gaagccaaga cccagtgggc gcatccggtc cgtgctgcat gcagatgaga tgtgagctgg   1680

aacagacctt cctggcccac ttcctgatca caaggaatcc tgggcttcct tatggctttg   1740

cttcccactg ggattcctac ttaggtgtct gccctcaggg gtccaaatca cttcaggaca   1800

ccccaagaga tgtcctttag tctctgcctg aggcctagtc tgcatttgtt tgcatatatg   1860

agagggtacc tcaaatactt ctgttatgta tctgtgattt tatttcttct ttgggtatag   1920

ggttgagggg aaataagttt tgagtgagaa ataaacgttt tagctgaaat tgtatcccag   1980

aagtttgaaa taagtagtag aagaggggga aaacaaggga gaagtggtgg ggaagacttg   2040

gtagattggg gccttaagta accacctcct ttccctctct gcccccatga cttcctgctc   2100

caagttacag aagggaagga aaccatttta ctctttttat tctgctcatt aatgatctga   2160

aagaagaaga tggggaaaag gggattccac cacaaggctc caaagaacca agagtgcaaa   2220

tcagtccatt tcactttcac tgtctgagat agggtctcta agacccagga tacaagggtg   2280

gaatgtagct atatggactc gatttgcttc cggacctttt ccagagcctt tctgtccaat   2340

tgtcgctgac gaatgatgac aagacaagcg aagatcaggg ccacacacac gacagcccct   2400

tcgaacttcc aaaataagcg ttgttccatc aaagctgagc ggcagctgag ggcaggaagg   2460

aatagttatt cccaaggaag gccagacagc ttctccctct aatttccctt ctacttcagc   2520

ctagccagga tacactcaag aggaaatcag agccaggctt ctattgtgtg tatagtacat   2580

aaatccctct caaatagatc atttaattta ttctctggat aagcagagct agtattaacc   2640

aattttactg atgagaaaat atggccaata acatagtgct gaggagtaga gctgggactt   2700

gggttcaagt aatttggctc caaatcccgt cttctttctt attatttttg agatggt      2757


<210>  823
<211>  395
<212>  PRT
<213>  Homo sapiens

<400>  823


Met Asp Leu Gly Ile Pro Asp Leu Leu Asp Ala Trp Leu Glu Pro Pro 
1               5                   10                  15      


Glu Asp Ile Phe Ser Thr Gly Ser Val Leu Glu Leu Gly Leu His Cys 
            20                  25                  30          


Pro Pro Pro Glu Val Pro Val Thr Arg Leu Gln Glu Gln Gly Leu Gln 
        35                  40                  45              


Gly Trp Lys Ser Gly Gly Asp Arg Gly Cys Gly Leu Gln Glu Ser Glu 
    50                  55                  60                  


Pro Glu Asp Phe Leu Lys Leu Phe Ile Asp Pro Asn Glu Val Tyr Cys 
65                  70                  75                  80  


Ser Glu Ala Ser Pro Gly Ser Asp Ser Gly Ile Ser Glu Asp Pro Cys 
                85                  90                  95      


His Pro Asp Ser Pro Pro Ala Pro Arg Ala Thr Ser Ser Pro Met Leu 
            100                 105                 110         


Tyr Glu Val Val Tyr Glu Ala Gly Ala Leu Glu Arg Met Gln Gly Glu 
        115                 120                 125             


Thr Gly Pro Asn Val Gly Leu Ile Ser Ile Gln Leu Asp Gln Trp Ser 
    130                 135                 140                 


Pro Ala Phe Met Val Pro Asp Ser Cys Met Val Ser Glu Leu Pro Phe 
145                 150                 155                 160 


Asp Ala His Ala His Ile Leu Pro Arg Ala Gly Thr Val Ala Pro Val 
                165                 170                 175     


Pro Cys Thr Thr Leu Leu Pro Cys Gln Thr Leu Phe Leu Thr Asp Glu 
            180                 185                 190         


Glu Lys Arg Leu Leu Gly Gln Glu Gly Val Ser Leu Pro Ser His Leu 
        195                 200                 205             


Pro Leu Thr Lys Ala Glu Glu Arg Val Leu Lys Lys Val Arg Arg Lys 
    210                 215                 220                 


Ile Arg Asn Lys Gln Ser Ala Gln Asp Ser Arg Arg Arg Lys Lys Glu 
225                 230                 235                 240 


Tyr Ile Asp Gly Leu Glu Ser Arg Val Ala Ala Cys Ser Ala Gln Asn 
                245                 250                 255     


Gln Glu Leu Gln Lys Lys Val Gln Glu Leu Glu Arg His Asn Ile Ser 
            260                 265                 270         


Leu Val Ala Gln Leu Arg Gln Leu Gln Thr Leu Ile Ala Gln Thr Ser 
        275                 280                 285             


Asn Lys Ala Ala Gln Thr Ser Thr Cys Val Leu Ile Leu Leu Phe Ser 
    290                 295                 300                 


Leu Ala Leu Ile Ile Leu Pro Ser Phe Ser Pro Phe Gln Ser Arg Pro 
305                 310                 315                 320 


Glu Ala Gly Ser Glu Asp Tyr Gln Pro His Gly Val Thr Ser Arg Asn 
                325                 330                 335     


Ile Leu Thr His Lys Asp Val Thr Glu Asn Leu Glu Thr Gln Val Val 
            340                 345                 350         


Glu Ser Arg Leu Arg Glu Pro Pro Gly Ala Lys Asp Ala Asn Gly Ser 
        355                 360                 365             


Thr Arg Thr Leu Leu Glu Lys Met Gly Gly Lys Pro Arg Pro Ser Gly 
    370                 375                 380                 


Arg Ile Arg Ser Val Leu His Ala Asp Glu Met 
385                 390                 395 

<210>  824
<211>  581
<212>  DNA
<213>  Homo sapiens

<400>  824
agagcgccac gcggtgggcg aggggatgcc ctagtaaatt cgcagctagg agacaccaaa     60

ccctcaggaa gatttactat agctaagaga aaactgcagc agaaagggcg cggctaccta    120

cttcttaaat tccgtttgtg gaccctcaga ctcttagtcc cctactccca gatacagcgg    180

ccctaccgtg gctcctggca agaagcatgg atctcggaat ccctgacctg ctggacgcgt    240

ggctggagcc cccagaggat atcttctcga caggatccgt cctggagctg ggactccact    300

gcccccctcc agaggttccg gtaactaggc tacaggaaca gggactgcaa ggctggaagt    360

ccggtgggga ccgtggctgt gtgagtgtga cgagtgggag tgggggtggg gttgagacac    420

aactctgtga taagaggctt cagctcccac ttggagacag gtctgaaaac agaccacccc    480

caaaatagac gtaagttgta taataactgt ctccatgccc aagaagtgaa aggactgaaa    540

atgaagcata agtcagggag gacttccaaa attcttccct g                        581


<210>  825
<211>  93
<212>  PRT
<213>  Homo sapiens

<400>  825


Met Asp Leu Gly Ile Pro Asp Leu Leu Asp Ala Trp Leu Glu Pro Pro 
1               5                   10                  15      


Glu Asp Ile Phe Ser Thr Gly Ser Val Leu Glu Leu Gly Leu His Cys 
            20                  25                  30          


Pro Pro Pro Glu Val Pro Val Thr Arg Leu Gln Glu Gln Gly Leu Gln 
        35                  40                  45              


Gly Trp Lys Ser Gly Gly Asp Arg Gly Cys Val Ser Val Thr Ser Gly 
    50                  55                  60                  


Ser Gly Gly Gly Val Glu Thr Gln Leu Cys Asp Lys Arg Leu Gln Leu 
65                  70                  75                  80  


Pro Leu Gly Asp Arg Ser Glu Asn Arg Pro Pro Pro Lys 
                85                  90              

<210>  826
<211>  900
<212>  DNA
<213>  Homo sapiens

<400>  826
ctagtaaatt cgcaggtctc ttgactcttt ccgcctttgt ttacaaccct gccatgatct     60

ccctcttgca aaagcgaggg ctacagaaca ggcattcagg agtcctgtgc tccagtcaca    120

gccttttctg ttcttcagct aggagacacc aaaccctcag gaagatttac tatagctaag    180

agaaaactgc agcagaaagg gcgcggctac ctacttctta aattccgttt gtggaccctc    240

agactcttag tcccctactc ccagatacag cggccctacc gtggctcctg gcaagaagca    300

tggatctcgg aatccctgac ctgctggacg cgtggctgga gcccccagag gatatcttct    360

cgacaggatc cgtcctggag ctgggactcc actgcccccc tccagaggtt ccgggccttc    420

aagagagtga gcctgaagat ttcttgaagc ttttcattga tcccaatgag gtgtactgct    480

cagaagcatc tcctggcagt gacagtggca tctctgagga cccctgccat ccagacagtc    540

cccctgcccc cagggcaacc agttctccta tgctctatga ggttgtctat gaggcagggg    600

ccctggagag gatgcagggg gaaactgggc caaatgtagg ccttatctcc atccagctag    660

atcagtggag cccagcattt atggtgcctg attcctgcat ggtcagtgag ctgccctttg    720

atgctcatgc ccacatcctg cccagagcag gcaccgtagc cccagtgccc tgtacaaccc    780

tgggtcttac tctgtcatcc aggctggagt gcagtggtgc aatcacggct cactgcatcc    840

tcaacatctt gggctcaagc aatcctcctg cctcagcctc ctgagtagct gggactacag    900


<210>  827
<211>  194
<212>  PRT
<213>  Homo sapiens

<400>  827


Met Asp Leu Gly Ile Pro Asp Leu Leu Asp Ala Trp Leu Glu Pro Pro 
1               5                   10                  15      


Glu Asp Ile Phe Ser Thr Gly Ser Val Leu Glu Leu Gly Leu His Cys 
            20                  25                  30          


Pro Pro Pro Glu Val Pro Gly Leu Gln Glu Ser Glu Pro Glu Asp Phe 
        35                  40                  45              


Leu Lys Leu Phe Ile Asp Pro Asn Glu Val Tyr Cys Ser Glu Ala Ser 
    50                  55                  60                  


Pro Gly Ser Asp Ser Gly Ile Ser Glu Asp Pro Cys His Pro Asp Ser 
65                  70                  75                  80  


Pro Pro Ala Pro Arg Ala Thr Ser Ser Pro Met Leu Tyr Glu Val Val 
                85                  90                  95      


Tyr Glu Ala Gly Ala Leu Glu Arg Met Gln Gly Glu Thr Gly Pro Asn 
            100                 105                 110         


Val Gly Leu Ile Ser Ile Gln Leu Asp Gln Trp Ser Pro Ala Phe Met 
        115                 120                 125             


Val Pro Asp Ser Cys Met Val Ser Glu Leu Pro Phe Asp Ala His Ala 
    130                 135                 140                 


His Ile Leu Pro Arg Ala Gly Thr Val Ala Pro Val Pro Cys Thr Thr 
145                 150                 155                 160 


Leu Gly Leu Thr Leu Ser Ser Arg Leu Glu Cys Ser Gly Ala Ile Thr 
                165                 170                 175     


Ala His Cys Ile Leu Asn Ile Leu Gly Ser Ser Asn Pro Pro Ala Ser 
            180                 185                 190         


Ala Ser 
        

<210>  828
<211>  1725
<212>  DNA
<213>  Homo sapiens

<400>  828
ctagtaaatt cgcaggtctc ttgactcttt ccgcctttgt ttacaaccct gccatgatct     60

ccctcttgca aaagcgaggg ctacagaaca ggcattcagg agtcctgtgc tccagtcaca    120

gccttttctg ttcttcagct aggagacacc aaaccctcag gaagatttac tatagctaag    180

agaaaactgc agcagaaagg gcgcggctac ctacttctta aattccgttt gtggaccctc    240

agactcttag tcccctactc ccagatacag cggccctacc gtggctcctg gcaagaagca    300

tggatctcgg aatccctgac ctgctggacg cgtggctgga gcccccagag gatatcttct    360

cgacaggatc cgtcctggag ctgggactcc actgcccccc tccagaggtt ccgggccttc    420

aagagagtga gcctgaagat ttcttgaagc ttttcattga tcccaatgag gtgtactgct    480

cagaagcatc tcctggcagt gacagtggca tctctgagga cccctgccat ccagacagtc    540

cccctgcccc cagggcaacc agttctccta tgctctatga ggttgtctat gaggcagggg    600

ccctggagag gatgcagggg gaaactgggc caaatgtagg ccttatctcc atccagctag    660

atcagtggag cccagcattt atggtgcctg attcctgcat ggtcagtgag ctgccctttg    720

atgctcatgc ccacatcctg cccagagcag gcaccgtagc cccagtgccc tgtacaaccc    780

tgctgccctg tcaaaccctg ttcctgaccg atgaggagaa gcgtctgctg gggcaggaag    840

gggtttccct gccctctcac ctgcccctca ccaaggcaga ggagagggtc ctcaagaagg    900

tcaggaggaa aatccgtaac aagcagtcag ctcaggacag tcggcggcgg aagaaggagt    960

acattgatgg gctggagagc agggtggcag cctgttctgc acagaaccaa gaattacaga   1020

aaaaagtcca ggagctggag aggcacaaca tctccttggt agctcagctc cgccagctgc   1080

agacgctaat tgctcaaact tccaacaaag ctgcccagac cagcacttgt gttttgattc   1140

ttcttttttc cctggctctc atcatcctgc ccagcttcag tccattccag agtcgaccag   1200

aagctgggtc tgaggattac cagcctcacg gagtgacttc cagaaatatc ctgacccaca   1260

aggacgtaac agaaaatctg gagacccaag tggtagagtc cagactgagg gagccacctg   1320

gagccaagga tgcaaatggc tcaacaagga cactgcttga gaagatggga gggaagccaa   1380

gacccagtgg gcgcatccgg tccgtgctgc atgcagatga gatgtgagct ggaacagacc   1440

ttcctggccc acttcctgat cacaaggaat cctgggcttc cttatggctt tgcttcccac   1500

tgggattcct acttaggtgt ctgccctcag gggtccaaat cacttcagga caccccaaga   1560

gatgtccttt agtctctgcc tgaggcctag tctgcatttg tttgcatata tgagagggta   1620

cctcaaatac ttctgttatg tatctgtgat tttatttctt ctttgggtat agggttgagg   1680

ggaaataagt tttgagtgag aaataaacgt tttagctgaa attgt                   1725


<210>  829
<211>  375
<212>  PRT
<213>  Homo sapiens

<400>  829


Met Asp Leu Gly Ile Pro Asp Leu Leu Asp Ala Trp Leu Glu Pro Pro 
1               5                   10                  15      


Glu Asp Ile Phe Ser Thr Gly Ser Val Leu Glu Leu Gly Leu His Cys 
            20                  25                  30          


Pro Pro Pro Glu Val Pro Gly Leu Gln Glu Ser Glu Pro Glu Asp Phe 
        35                  40                  45              


Leu Lys Leu Phe Ile Asp Pro Asn Glu Val Tyr Cys Ser Glu Ala Ser 
    50                  55                  60                  


Pro Gly Ser Asp Ser Gly Ile Ser Glu Asp Pro Cys His Pro Asp Ser 
65                  70                  75                  80  


Pro Pro Ala Pro Arg Ala Thr Ser Ser Pro Met Leu Tyr Glu Val Val 
                85                  90                  95      


Tyr Glu Ala Gly Ala Leu Glu Arg Met Gln Gly Glu Thr Gly Pro Asn 
            100                 105                 110         


Val Gly Leu Ile Ser Ile Gln Leu Asp Gln Trp Ser Pro Ala Phe Met 
        115                 120                 125             


Val Pro Asp Ser Cys Met Val Ser Glu Leu Pro Phe Asp Ala His Ala 
    130                 135                 140                 


His Ile Leu Pro Arg Ala Gly Thr Val Ala Pro Val Pro Cys Thr Thr 
145                 150                 155                 160 


Leu Leu Pro Cys Gln Thr Leu Phe Leu Thr Asp Glu Glu Lys Arg Leu 
                165                 170                 175     


Leu Gly Gln Glu Gly Val Ser Leu Pro Ser His Leu Pro Leu Thr Lys 
            180                 185                 190         


Ala Glu Glu Arg Val Leu Lys Lys Val Arg Arg Lys Ile Arg Asn Lys 
        195                 200                 205             


Gln Ser Ala Gln Asp Ser Arg Arg Arg Lys Lys Glu Tyr Ile Asp Gly 
    210                 215                 220                 


Leu Glu Ser Arg Val Ala Ala Cys Ser Ala Gln Asn Gln Glu Leu Gln 
225                 230                 235                 240 


Lys Lys Val Gln Glu Leu Glu Arg His Asn Ile Ser Leu Val Ala Gln 
                245                 250                 255     


Leu Arg Gln Leu Gln Thr Leu Ile Ala Gln Thr Ser Asn Lys Ala Ala 
            260                 265                 270         


Gln Thr Ser Thr Cys Val Leu Ile Leu Leu Phe Ser Leu Ala Leu Ile 
        275                 280                 285             


Ile Leu Pro Ser Phe Ser Pro Phe Gln Ser Arg Pro Glu Ala Gly Ser 
    290                 295                 300                 


Glu Asp Tyr Gln Pro His Gly Val Thr Ser Arg Asn Ile Leu Thr His 
305                 310                 315                 320 


Lys Asp Val Thr Glu Asn Leu Glu Thr Gln Val Val Glu Ser Arg Leu 
                325                 330                 335     


Arg Glu Pro Pro Gly Ala Lys Asp Ala Asn Gly Ser Thr Arg Thr Leu 
            340                 345                 350         


Leu Glu Lys Met Gly Gly Lys Pro Arg Pro Ser Gly Arg Ile Arg Ser 
        355                 360                 365             


Val Leu His Ala Asp Glu Met 
    370                 375 

<210>  830
<211>  2509
<212>  DNA
<213>  Homo sapiens

<400>  830
ctagtaaatt cgcaggtctc ttgactcttt ccgcctttgt ttacaaccct gccatgatct     60

ccctcttgca aaagcgaggg ctacagaaca ggcattcagg agtcctgtgc tccagtcaca    120

gccttttctg ttcttcagct aggagacacc aaaccctcag gaagatttac tatagctaag    180

agaaaactgc agcagaaagg gcgcggctac ctacttctta aattccgttt gtggaccctc    240

agactcttag tcccctactc ccagatacag cggccctacc gtggctcctg gcaagaagca    300

tggatctcgg aatccctgac ctgctggacg cgtggctgga gcccccagag gatatcttct    360

cgacaggatc cgtcctggag ctgggactcc actgcccccc tccagaggtt ccgggccttc    420

aagagagtga gcctgaagat ttcttgaagc ttttcattga tcccaatgag gtgtactgct    480

cagaagcatc tcctggcagt gacagtggca tctctgagga cccctgccat ccagacagtc    540

cccctgcccc cagggcaacc agttctccta tgctctatga ggttgtctat gaggcagggg    600

ccctggagag gatgcagggg gaaactgggc caaatgtagg ccttatctcc atccagctag    660

atcagtggag cccagcattt atggtgcctg attcctgcat ggtcagtgag ctgccctttg    720

atgctcatgc ccacatcctg cccagagcag gcaccgtagc cccagtgccc tgtacaaccc    780

tgctgccctg tcaaaccctg ttcctgaccg atgaggagaa gcgtctgctg gggcaggaag    840

gggtttccct gccctctcac ctgcccctca ccaaggcaga ggagagggtc ctcaagaagg    900

tcaggaggaa aatccgtaac aagcagtcag ctcaggacag tcggcggcgg aagaaggagt    960

acattgatgg gctggagagc agggtggcag cctgttctgc acagaaccaa gaattacaga   1020

aaaaagtcca ggagctggag aggcacaaca tctccttggt agctcagctc cgccagctgc   1080

agacgctaat tgctcaaact tccaacaaag ctgcccagac cagcacttgt gttttgattc   1140

ttcttttttc cctggctctc atcatcctgc ccagcttcag tccattccag agtcgaccag   1200

aagctgggtc tgaggattac cagcctcacg gagtgacttc cagaaatatc ctgacccaca   1260

aggacgtaac agaaaatctg gagacccaag tggtagagtc cagactgagg gagccacctg   1320

gagccaagga tgcaaatggc tcaacaagga cactgcttga gaagatggga gggaagccaa   1380

gacccagtgg gcgcatccgg tccgtgctgc atgcagatga gatgtgagct ggaacagacc   1440

ttcctggccc acttcctgat cacaaggaat cctgggcttc cttatggctt tgcttcccac   1500

tgggattcct acttaggtgt ctgccctcag gggtccaaat cacttcagga caccccaaga   1560

gatgtccttt agtctctgcc tgaggcctag tctgcatttg tttgcatata tgagagggta   1620

cctcaaatac ttctgttatg tatctgtgat tttatttctt ctttgggtat agggttgagg   1680

ggaaataagt tttgagtgag aaataaacgt tttagctgaa attgtatccc agaagtttga   1740

aataagtagt agaagagggg gaaaacaagg gagaagtggt ggggaagact tggtagattg   1800

gggccttaag taaccacctc ctttccctct ctgcccccat gacttcctgc tccaagttac   1860

agaagggaag gaaaccattt tactcttttt attctgctca ttaatgatct gaaagaagaa   1920

gatggggaaa aggggattcc accacaaggc tccaaagaac caagagtgca aatcagtcca   1980

tttcactttc actgtctgag atagggtctc taagacccag gatacaaggg tggaatgtag   2040

ctatatggac tcgatttgct tccggacctt ttccagagcc tttctgtcca attgtcgctg   2100

acgaatgatg acaagacaag cgaagatcag ggccacacac acgacagccc cttcgaactt   2160

ccaaaataag cgttgttcca tcaaagctga gcggcagctg agggcaggaa ggaatagtta   2220

ttcccaagga aggccagaca gcttctccct ctaatttccc ttctacttca gcctagccag   2280

gatacactca agaggaaatc agagccaggc ttctattgtg tgtatagtac ataaatccct   2340

ctcaaataga tcatttaatt tattctctgg ataagcagag ctagtattaa ccaattttac   2400

tgatgagaaa atatggccaa taacatagtg ctgaggagta gagctgggac ttgggttcaa   2460

gtaatttggc tccaaatccc gtcttctttc ttattatttt tgagatggt               2509


<210>  831
<211>  375
<212>  PRT
<213>  Homo sapiens

<400>  831


Met Asp Leu Gly Ile Pro Asp Leu Leu Asp Ala Trp Leu Glu Pro Pro 
1               5                   10                  15      


Glu Asp Ile Phe Ser Thr Gly Ser Val Leu Glu Leu Gly Leu His Cys 
            20                  25                  30          


Pro Pro Pro Glu Val Pro Gly Leu Gln Glu Ser Glu Pro Glu Asp Phe 
        35                  40                  45              


Leu Lys Leu Phe Ile Asp Pro Asn Glu Val Tyr Cys Ser Glu Ala Ser 
    50                  55                  60                  


Pro Gly Ser Asp Ser Gly Ile Ser Glu Asp Pro Cys His Pro Asp Ser 
65                  70                  75                  80  


Pro Pro Ala Pro Arg Ala Thr Ser Ser Pro Met Leu Tyr Glu Val Val 
                85                  90                  95      


Tyr Glu Ala Gly Ala Leu Glu Arg Met Gln Gly Glu Thr Gly Pro Asn 
            100                 105                 110         


Val Gly Leu Ile Ser Ile Gln Leu Asp Gln Trp Ser Pro Ala Phe Met 
        115                 120                 125             


Val Pro Asp Ser Cys Met Val Ser Glu Leu Pro Phe Asp Ala His Ala 
    130                 135                 140                 


His Ile Leu Pro Arg Ala Gly Thr Val Ala Pro Val Pro Cys Thr Thr 
145                 150                 155                 160 


Leu Leu Pro Cys Gln Thr Leu Phe Leu Thr Asp Glu Glu Lys Arg Leu 
                165                 170                 175     


Leu Gly Gln Glu Gly Val Ser Leu Pro Ser His Leu Pro Leu Thr Lys 
            180                 185                 190         


Ala Glu Glu Arg Val Leu Lys Lys Val Arg Arg Lys Ile Arg Asn Lys 
        195                 200                 205             


Gln Ser Ala Gln Asp Ser Arg Arg Arg Lys Lys Glu Tyr Ile Asp Gly 
    210                 215                 220                 


Leu Glu Ser Arg Val Ala Ala Cys Ser Ala Gln Asn Gln Glu Leu Gln 
225                 230                 235                 240 


Lys Lys Val Gln Glu Leu Glu Arg His Asn Ile Ser Leu Val Ala Gln 
                245                 250                 255     


Leu Arg Gln Leu Gln Thr Leu Ile Ala Gln Thr Ser Asn Lys Ala Ala 
            260                 265                 270         


Gln Thr Ser Thr Cys Val Leu Ile Leu Leu Phe Ser Leu Ala Leu Ile 
        275                 280                 285             


Ile Leu Pro Ser Phe Ser Pro Phe Gln Ser Arg Pro Glu Ala Gly Ser 
    290                 295                 300                 


Glu Asp Tyr Gln Pro His Gly Val Thr Ser Arg Asn Ile Leu Thr His 
305                 310                 315                 320 


Lys Asp Val Thr Glu Asn Leu Glu Thr Gln Val Val Glu Ser Arg Leu 
                325                 330                 335     


Arg Glu Pro Pro Gly Ala Lys Asp Ala Asn Gly Ser Thr Arg Thr Leu 
            340                 345                 350         


Leu Glu Lys Met Gly Gly Lys Pro Arg Pro Ser Gly Arg Ile Arg Ser 
        355                 360                 365             


Val Leu His Ala Asp Glu Met 
    370                 375 

<210>  832
<211>  549
<212>  DNA
<213>  Homo sapiens

<400>  832
gtttacaacc ctgccatgat ctccctcttg caaaagcgag ggctacagaa caggcattca     60

ggagtcctgt gctccagtca cagccttttc tgttcttcag ctaggagaca ccaaaccctc    120

aggaagattt actatagcta agagaaaact gcagcagaaa gggcgcggct acctacttct    180

taaattccgt ttgtggaccc tcagactctt agtcccctac tcccagatac agcggcccta    240

ccgtggctcc tggcaagaag catggatctc ggaatccctg acctgctgga cgcgtggctg    300

gagcccccag aggatatctt ctcgacagga tccgtcctgg agctgggact ccactgcccc    360

cctccagagg ttccggtaac taggctacag gaacagggac tgcaaggctg gaagtccggt    420

ggggaccgtg gctgtgtgag tgtgacgagt gggagtgggg gtggggttga gacacaactc    480

tgtgataaga ggcttcagct cccacttgga gacaggtctg aaaacagacc acccccaaaa    540

tagacgtaa                                                            549


<210>  833
<211>  93
<212>  PRT
<213>  Homo sapiens

<400>  833


Met Asp Leu Gly Ile Pro Asp Leu Leu Asp Ala Trp Leu Glu Pro Pro 
1               5                   10                  15      


Glu Asp Ile Phe Ser Thr Gly Ser Val Leu Glu Leu Gly Leu His Cys 
            20                  25                  30          


Pro Pro Pro Glu Val Pro Val Thr Arg Leu Gln Glu Gln Gly Leu Gln 
        35                  40                  45              


Gly Trp Lys Ser Gly Gly Asp Arg Gly Cys Val Ser Val Thr Ser Gly 
    50                  55                  60                  


Ser Gly Gly Gly Val Glu Thr Gln Leu Cys Asp Lys Arg Leu Gln Leu 
65                  70                  75                  80  


Pro Leu Gly Asp Arg Ser Glu Asn Arg Pro Pro Pro Lys 
                85                  90              

<210>  834
<211>  1602
<212>  DNA
<213>  Homo sapiens

<400>  834
ggggtttggc tggcaggtcc aggatacgag atcctggaag aaagaaaagg tgtagtgttt     60

ggggaggtca acgggctatg ctggcttgac agggctgggc tcttcagaac agaagcatgg    120

atctcggaat ccctgacctg ctggacgcgt ggctggagcc cccagaggat atcttctcga    180

caggatccgt cctggagctg ggactccact gcccccctcc agaggttccg gtaactaggc    240

tacaggaaca gggactgcaa ggctggaagt ccggtgggga ccgtggctgt ggccttcaag    300

agagtgagcc tgaagatttc ttgaagcttt tcattgatcc caatgaggtg tactgctcag    360

aagcatctcc tggcagtgac agtggcatct ctgaggaccc ctgccatcca gacagtcccc    420

ctgcccccag ggcaaccagt tctcctatgc tctatgaggt tgtctatgag gcaggggccc    480

tggagaggat gcagggggaa actgggccaa atgtaggcct tatctccatc cagctagatc    540

agtggagccc agcatttatg gtgcctgatt cctgcatggt cagtgagctg ccctttgatg    600

ctcatgccca catcctgccc agagcaggca ccgtagcccc agtgccctgt acaaccctgc    660

tgccctgtca aaccctgttc ctgaccgatg aggagaagcg tctgctgggg caggaagggg    720

tttccctgcc ctctcacctg cccctcacca aggcagagga gagggtcctc aagaaggtca    780

ggaggaaaat ccgtaacaag cagtcagctc aggacagtcg gcggcggaag aaggagtaca    840

ttgatgggct ggagagcagg gtggcagcct gttctgcaca gaaccaagaa ttacagaaaa    900

aagtccagga gctggagagg cacaacatct ccttggtagc tcagctccgc cagctgcaga    960

cgctaattgc tcaaacttcc aacaaagctg cccagaccag cacttgtgtt ttgattcttc   1020

ttttttccct ggctctcatc atcctgccca gcttcagtcc attccagagt cgaccagaag   1080

ctgggtctga ggattaccag cctcacggag tgacttccag aaatatcctg acccacaagg   1140

acgtaacaga aaatctggag acccaagtgg tagagtccag actgagggag ccacctggag   1200

ccaaggatgc aaatggctca acaaggacac tgcttgagaa gatgggaggg aagccaagac   1260

ccagtgggcg catccggtcc gtgctgcatg cagatgagat gtgagctgga acagaccttc   1320

ctggcccact tcctgatcac aaggaatcct gggcttcctt atggctttgc ttcccactgg   1380

gattcctact taggtgtctg ccctcagggg tccaaatcac ttcaggacac cccaagagat   1440

gtcctttagt ctctgcctga ggcctagtct gcatttgttt gcatatatga gagggtacct   1500

caaatacttc tgttatgtat ctgtgatttt atttcttctt tgggtatagg gttgagggga   1560

aataagtttt gagtgagaaa taaacgtttt agctgaaatt gt                      1602


<210>  835
<211>  395
<212>  PRT
<213>  Homo sapiens

<400>  835


Met Asp Leu Gly Ile Pro Asp Leu Leu Asp Ala Trp Leu Glu Pro Pro 
1               5                   10                  15      


Glu Asp Ile Phe Ser Thr Gly Ser Val Leu Glu Leu Gly Leu His Cys 
            20                  25                  30          


Pro Pro Pro Glu Val Pro Val Thr Arg Leu Gln Glu Gln Gly Leu Gln 
        35                  40                  45              


Gly Trp Lys Ser Gly Gly Asp Arg Gly Cys Gly Leu Gln Glu Ser Glu 
    50                  55                  60                  


Pro Glu Asp Phe Leu Lys Leu Phe Ile Asp Pro Asn Glu Val Tyr Cys 
65                  70                  75                  80  


Ser Glu Ala Ser Pro Gly Ser Asp Ser Gly Ile Ser Glu Asp Pro Cys 
                85                  90                  95      


His Pro Asp Ser Pro Pro Ala Pro Arg Ala Thr Ser Ser Pro Met Leu 
            100                 105                 110         


Tyr Glu Val Val Tyr Glu Ala Gly Ala Leu Glu Arg Met Gln Gly Glu 
        115                 120                 125             


Thr Gly Pro Asn Val Gly Leu Ile Ser Ile Gln Leu Asp Gln Trp Ser 
    130                 135                 140                 


Pro Ala Phe Met Val Pro Asp Ser Cys Met Val Ser Glu Leu Pro Phe 
145                 150                 155                 160 


Asp Ala His Ala His Ile Leu Pro Arg Ala Gly Thr Val Ala Pro Val 
                165                 170                 175     


Pro Cys Thr Thr Leu Leu Pro Cys Gln Thr Leu Phe Leu Thr Asp Glu 
            180                 185                 190         


Glu Lys Arg Leu Leu Gly Gln Glu Gly Val Ser Leu Pro Ser His Leu 
        195                 200                 205             


Pro Leu Thr Lys Ala Glu Glu Arg Val Leu Lys Lys Val Arg Arg Lys 
    210                 215                 220                 


Ile Arg Asn Lys Gln Ser Ala Gln Asp Ser Arg Arg Arg Lys Lys Glu 
225                 230                 235                 240 


Tyr Ile Asp Gly Leu Glu Ser Arg Val Ala Ala Cys Ser Ala Gln Asn 
                245                 250                 255     


Gln Glu Leu Gln Lys Lys Val Gln Glu Leu Glu Arg His Asn Ile Ser 
            260                 265                 270         


Leu Val Ala Gln Leu Arg Gln Leu Gln Thr Leu Ile Ala Gln Thr Ser 
        275                 280                 285             


Asn Lys Ala Ala Gln Thr Ser Thr Cys Val Leu Ile Leu Leu Phe Ser 
    290                 295                 300                 


Leu Ala Leu Ile Ile Leu Pro Ser Phe Ser Pro Phe Gln Ser Arg Pro 
305                 310                 315                 320 


Glu Ala Gly Ser Glu Asp Tyr Gln Pro His Gly Val Thr Ser Arg Asn 
                325                 330                 335     


Ile Leu Thr His Lys Asp Val Thr Glu Asn Leu Glu Thr Gln Val Val 
            340                 345                 350         


Glu Ser Arg Leu Arg Glu Pro Pro Gly Ala Lys Asp Ala Asn Gly Ser 
        355                 360                 365             


Thr Arg Thr Leu Leu Glu Lys Met Gly Gly Lys Pro Arg Pro Ser Gly 
    370                 375                 380                 


Arg Ile Arg Ser Val Leu His Ala Asp Glu Met 
385                 390                 395 

<210>  836
<211>  2386
<212>  DNA
<213>  Homo sapiens

<400>  836
ggggtttggc tggcaggtcc aggatacgag atcctggaag aaagaaaagg tgtagtgttt     60

ggggaggtca acgggctatg ctggcttgac agggctgggc tcttcagaac agaagcatgg    120

atctcggaat ccctgacctg ctggacgcgt ggctggagcc cccagaggat atcttctcga    180

caggatccgt cctggagctg ggactccact gcccccctcc agaggttccg gtaactaggc    240

tacaggaaca gggactgcaa ggctggaagt ccggtgggga ccgtggctgt ggccttcaag    300

agagtgagcc tgaagatttc ttgaagcttt tcattgatcc caatgaggtg tactgctcag    360

aagcatctcc tggcagtgac agtggcatct ctgaggaccc ctgccatcca gacagtcccc    420

ctgcccccag ggcaaccagt tctcctatgc tctatgaggt tgtctatgag gcaggggccc    480

tggagaggat gcagggggaa actgggccaa atgtaggcct tatctccatc cagctagatc    540

agtggagccc agcatttatg gtgcctgatt cctgcatggt cagtgagctg ccctttgatg    600

ctcatgccca catcctgccc agagcaggca ccgtagcccc agtgccctgt acaaccctgc    660

tgccctgtca aaccctgttc ctgaccgatg aggagaagcg tctgctgggg caggaagggg    720

tttccctgcc ctctcacctg cccctcacca aggcagagga gagggtcctc aagaaggtca    780

ggaggaaaat ccgtaacaag cagtcagctc aggacagtcg gcggcggaag aaggagtaca    840

ttgatgggct ggagagcagg gtggcagcct gttctgcaca gaaccaagaa ttacagaaaa    900

aagtccagga gctggagagg cacaacatct ccttggtagc tcagctccgc cagctgcaga    960

cgctaattgc tcaaacttcc aacaaagctg cccagaccag cacttgtgtt ttgattcttc   1020

ttttttccct ggctctcatc atcctgccca gcttcagtcc attccagagt cgaccagaag   1080

ctgggtctga ggattaccag cctcacggag tgacttccag aaatatcctg acccacaagg   1140

acgtaacaga aaatctggag acccaagtgg tagagtccag actgagggag ccacctggag   1200

ccaaggatgc aaatggctca acaaggacac tgcttgagaa gatgggaggg aagccaagac   1260

ccagtgggcg catccggtcc gtgctgcatg cagatgagat gtgagctgga acagaccttc   1320

ctggcccact tcctgatcac aaggaatcct gggcttcctt atggctttgc ttcccactgg   1380

gattcctact taggtgtctg ccctcagggg tccaaatcac ttcaggacac cccaagagat   1440

gtcctttagt ctctgcctga ggcctagtct gcatttgttt gcatatatga gagggtacct   1500

caaatacttc tgttatgtat ctgtgatttt atttcttctt tgggtatagg gttgagggga   1560

aataagtttt gagtgagaaa taaacgtttt agctgaaatt gtatcccaga agtttgaaat   1620

aagtagtaga agagggggaa aacaagggag aagtggtggg gaagacttgg tagattgggg   1680

ccttaagtaa ccacctcctt tccctctctg cccccatgac ttcctgctcc aagttacaga   1740

agggaaggaa accattttac tctttttatt ctgctcatta atgatctgaa agaagaagat   1800

ggggaaaagg ggattccacc acaaggctcc aaagaaccaa gagtgcaaat cagtccattt   1860

cactttcact gtctgagata gggtctctaa gacccaggat acaagggtgg aatgtagcta   1920

tatggactcg atttgcttcc ggaccttttc cagagccttt ctgtccaatt gtcgctgacg   1980

aatgatgaca agacaagcga agatcagggc cacacacacg acagcccctt cgaacttcca   2040

aaataagcgt tgttccatca aagctgagcg gcagctgagg gcaggaagga atagttattc   2100

ccaaggaagg ccagacagct tctccctcta atttcccttc tacttcagcc tagccaggat   2160

acactcaaga ggaaatcaga gccaggcttc tattgtgtgt atagtacata aatccctctc   2220

aaatagatca tttaatttat tctctggata agcagagcta gtattaacca attttactga   2280

tgagaaaata tggccaataa catagtgctg aggagtagag ctgggacttg ggttcaagta   2340

atttggctcc aaatcccgtc ttctttctta ttatttttga gatggt                  2386


<210>  837
<211>  395
<212>  PRT
<213>  Homo sapiens

<400>  837


Met Asp Leu Gly Ile Pro Asp Leu Leu Asp Ala Trp Leu Glu Pro Pro 
1               5                   10                  15      


Glu Asp Ile Phe Ser Thr Gly Ser Val Leu Glu Leu Gly Leu His Cys 
            20                  25                  30          


Pro Pro Pro Glu Val Pro Val Thr Arg Leu Gln Glu Gln Gly Leu Gln 
        35                  40                  45              


Gly Trp Lys Ser Gly Gly Asp Arg Gly Cys Gly Leu Gln Glu Ser Glu 
    50                  55                  60                  


Pro Glu Asp Phe Leu Lys Leu Phe Ile Asp Pro Asn Glu Val Tyr Cys 
65                  70                  75                  80  


Ser Glu Ala Ser Pro Gly Ser Asp Ser Gly Ile Ser Glu Asp Pro Cys 
                85                  90                  95      


His Pro Asp Ser Pro Pro Ala Pro Arg Ala Thr Ser Ser Pro Met Leu 
            100                 105                 110         


Tyr Glu Val Val Tyr Glu Ala Gly Ala Leu Glu Arg Met Gln Gly Glu 
        115                 120                 125             


Thr Gly Pro Asn Val Gly Leu Ile Ser Ile Gln Leu Asp Gln Trp Ser 
    130                 135                 140                 


Pro Ala Phe Met Val Pro Asp Ser Cys Met Val Ser Glu Leu Pro Phe 
145                 150                 155                 160 


Asp Ala His Ala His Ile Leu Pro Arg Ala Gly Thr Val Ala Pro Val 
                165                 170                 175     


Pro Cys Thr Thr Leu Leu Pro Cys Gln Thr Leu Phe Leu Thr Asp Glu 
            180                 185                 190         


Glu Lys Arg Leu Leu Gly Gln Glu Gly Val Ser Leu Pro Ser His Leu 
        195                 200                 205             


Pro Leu Thr Lys Ala Glu Glu Arg Val Leu Lys Lys Val Arg Arg Lys 
    210                 215                 220                 


Ile Arg Asn Lys Gln Ser Ala Gln Asp Ser Arg Arg Arg Lys Lys Glu 
225                 230                 235                 240 


Tyr Ile Asp Gly Leu Glu Ser Arg Val Ala Ala Cys Ser Ala Gln Asn 
                245                 250                 255     


Gln Glu Leu Gln Lys Lys Val Gln Glu Leu Glu Arg His Asn Ile Ser 
            260                 265                 270         


Leu Val Ala Gln Leu Arg Gln Leu Gln Thr Leu Ile Ala Gln Thr Ser 
        275                 280                 285             


Asn Lys Ala Ala Gln Thr Ser Thr Cys Val Leu Ile Leu Leu Phe Ser 
    290                 295                 300                 


Leu Ala Leu Ile Ile Leu Pro Ser Phe Ser Pro Phe Gln Ser Arg Pro 
305                 310                 315                 320 


Glu Ala Gly Ser Glu Asp Tyr Gln Pro His Gly Val Thr Ser Arg Asn 
                325                 330                 335     


Ile Leu Thr His Lys Asp Val Thr Glu Asn Leu Glu Thr Gln Val Val 
            340                 345                 350         


Glu Ser Arg Leu Arg Glu Pro Pro Gly Ala Lys Asp Ala Asn Gly Ser 
        355                 360                 365             


Thr Arg Thr Leu Leu Glu Lys Met Gly Gly Lys Pro Arg Pro Ser Gly 
    370                 375                 380                 


Arg Ile Arg Ser Val Leu His Ala Asp Glu Met 
385                 390                 395 

<210>  838
<211>  1498
<212>  DNA
<213>  Homo sapiens

<400>  838
aaaaggtgta gtgtttgggg aggtcaacgg gctatgctgg cttgacaggg ctgggctctt     60

cagaacagaa gcatggatct cggaatccct gacctgctgg acgcgtggct ggagccccca    120

gaggatatct tctcgacagg atccgtcctg gagctgggac tccactgccc ccctccagag    180

gttccgggcc ttcaagagag tgagcctgaa gatttcttga agcttttcat tgatcccaat    240

gaggtgtact gctcagaagc atctcctggc agtgacagtg gcatctctga ggacccctgc    300

catccagaca gtccccctgc ccccagggca accagttctc ctatgctcta tgaggttgtc    360

tatgaggcag gggccctgga gaggatgcag ggggaaactg ggccaaatgt aggccttatc    420

tccatccagc tagatcagtg gagcccagca tttatggtgc ctgattcctg catggtcagt    480

gagctgccct ttgatgctca tgcccacatc ctgcccagag caggcaccgt agccccagtg    540

ccctgtacaa ccctgctgcc ctgtcaaacc ctgttcctga ccgatgagga gaagcgtctg    600

ctggggcagg aaggggtttc cctgccctct cacctgcccc tcaccaaggc agaggagagg    660

gtcctcaaga aggtcaggag gaaaatccgt aacaagcagt cagctcagga cagtcggcgg    720

cggaagaagg agtacattga tgggctggag agcagggtgg cagcctgttc tgcacagaac    780

caagaattac agaaaaaagt ccaggagctg gagaggcaca acatctcctt ggtagctcag    840

ctccgccagc tgcagacgct aattgctcaa acttccaaca aagctgccca gaccagcact    900

tgtgttttga ttcttctttt ttccctggct ctcatcatcc tgcccagctt cagtccattc    960

cagagtcgac cagaagctgg gtctgaggat taccagcctc acggagtgac ttccagaaat   1020

atcctgaccc acaaggacgt aacagaaaat ctggagaccc aagtggtaga gtccagactg   1080

agggagccac ctggagccaa ggatgcaaat ggctcaacaa ggacactgct tgagaagatg   1140

ggagggaagc caagacccag tgggcgcatc cggtccgtgc tgcatgcaga tgagatgtga   1200

gctggaacag accttcctgg cccacttcct gatcacaagg aatcctgggc ttccttatgg   1260

ctttgcttcc cactgggatt cctacttagg tgtctgccct caggggtcca aatcacttca   1320

ggacacccca agagatgtcc tttagtctct gcctgaggcc tagtctgcat ttgtttgcat   1380

atatgagagg gtacctcaaa tacttctgtt atgtatctgt gattttattt cttctttggg   1440

tatagggttg aggggaaata agttttgagt gagaaataaa cgttttagct gaaattgt     1498


<210>  839
<211>  375
<212>  PRT
<213>  Homo sapiens

<400>  839


Met Asp Leu Gly Ile Pro Asp Leu Leu Asp Ala Trp Leu Glu Pro Pro 
1               5                   10                  15      


Glu Asp Ile Phe Ser Thr Gly Ser Val Leu Glu Leu Gly Leu His Cys 
            20                  25                  30          


Pro Pro Pro Glu Val Pro Gly Leu Gln Glu Ser Glu Pro Glu Asp Phe 
        35                  40                  45              


Leu Lys Leu Phe Ile Asp Pro Asn Glu Val Tyr Cys Ser Glu Ala Ser 
    50                  55                  60                  


Pro Gly Ser Asp Ser Gly Ile Ser Glu Asp Pro Cys His Pro Asp Ser 
65                  70                  75                  80  


Pro Pro Ala Pro Arg Ala Thr Ser Ser Pro Met Leu Tyr Glu Val Val 
                85                  90                  95      


Tyr Glu Ala Gly Ala Leu Glu Arg Met Gln Gly Glu Thr Gly Pro Asn 
            100                 105                 110         


Val Gly Leu Ile Ser Ile Gln Leu Asp Gln Trp Ser Pro Ala Phe Met 
        115                 120                 125             


Val Pro Asp Ser Cys Met Val Ser Glu Leu Pro Phe Asp Ala His Ala 
    130                 135                 140                 


His Ile Leu Pro Arg Ala Gly Thr Val Ala Pro Val Pro Cys Thr Thr 
145                 150                 155                 160 


Leu Leu Pro Cys Gln Thr Leu Phe Leu Thr Asp Glu Glu Lys Arg Leu 
                165                 170                 175     


Leu Gly Gln Glu Gly Val Ser Leu Pro Ser His Leu Pro Leu Thr Lys 
            180                 185                 190         


Ala Glu Glu Arg Val Leu Lys Lys Val Arg Arg Lys Ile Arg Asn Lys 
        195                 200                 205             


Gln Ser Ala Gln Asp Ser Arg Arg Arg Lys Lys Glu Tyr Ile Asp Gly 
    210                 215                 220                 


Leu Glu Ser Arg Val Ala Ala Cys Ser Ala Gln Asn Gln Glu Leu Gln 
225                 230                 235                 240 


Lys Lys Val Gln Glu Leu Glu Arg His Asn Ile Ser Leu Val Ala Gln 
                245                 250                 255     


Leu Arg Gln Leu Gln Thr Leu Ile Ala Gln Thr Ser Asn Lys Ala Ala 
            260                 265                 270         


Gln Thr Ser Thr Cys Val Leu Ile Leu Leu Phe Ser Leu Ala Leu Ile 
        275                 280                 285             


Ile Leu Pro Ser Phe Ser Pro Phe Gln Ser Arg Pro Glu Ala Gly Ser 
    290                 295                 300                 


Glu Asp Tyr Gln Pro His Gly Val Thr Ser Arg Asn Ile Leu Thr His 
305                 310                 315                 320 


Lys Asp Val Thr Glu Asn Leu Glu Thr Gln Val Val Glu Ser Arg Leu 
                325                 330                 335     


Arg Glu Pro Pro Gly Ala Lys Asp Ala Asn Gly Ser Thr Arg Thr Leu 
            340                 345                 350         


Leu Glu Lys Met Gly Gly Lys Pro Arg Pro Ser Gly Arg Ile Arg Ser 
        355                 360                 365             


Val Leu His Ala Asp Glu Met 
    370                 375 

<210>  840
<211>  886
<212>  DNA
<213>  Homo sapiens

<400>  840
gtagtgtttg gggaggtcaa cgggctatgc tggcttgaca gggctgggct cttcagaaca     60

gaagcatgga tctcggaatc cctgacctgc tggacgcgtg gctggagccc ccagaggata    120

tcttctcgac aggatccgtc ctggagctgg gactccactg cccccctcca gaggttccgg    180

taactaggct acaggaacag ggactgcaag gctggaagtc cggtggggac cgtggctgtg    240

tgagtgtgac gagtgggagt gggggtgggg ttgagacaca actctgtgat aagaggcttc    300

agctcccact tggagacagg tctgaaaaca gaccaccccc aaaatagacg taagttgtat    360

aataactgtc tccatgccca agaagtgaaa ggactgaaaa tgaagcataa gtcagggagg    420

acttccaaaa ttcttccctg cacatatata taaccttttc ctactgtagg gccttcaaga    480

gagtgagcct gaagatttct tgaagctttt cattgatccc aatgaggtgt actgctcaga    540

agcatctcct ggcagtgaca gtggcatctc tgaggacccc tgccatccag acagtccccc    600

tgcccccagg gcaaccagtt ctcctatgct ctatgaggtt gtctatgagg caggggccct    660

ggagaggatg cagggggaaa ctgggccaaa tgtaggcctt atctccatcc agctaggtca    720

gtgttctttg tgggaagggg gaaatggccc ttcgggactg gccctaacca tggggttaag    780

ggggtttacc caacctgtgc cactacccag gccctgcggc tgtcagggtg ttcctaagtc    840

tcctttctcc cagctacctg ttttctactc cagatcagtg gagccc                   886


<210>  841
<211>  93
<212>  PRT
<213>  Homo sapiens

<400>  841


Met Asp Leu Gly Ile Pro Asp Leu Leu Asp Ala Trp Leu Glu Pro Pro 
1               5                   10                  15      


Glu Asp Ile Phe Ser Thr Gly Ser Val Leu Glu Leu Gly Leu His Cys 
            20                  25                  30          


Pro Pro Pro Glu Val Pro Val Thr Arg Leu Gln Glu Gln Gly Leu Gln 
        35                  40                  45              


Gly Trp Lys Ser Gly Gly Asp Arg Gly Cys Val Ser Val Thr Ser Gly 
    50                  55                  60                  


Ser Gly Gly Gly Val Glu Thr Gln Leu Cys Asp Lys Arg Leu Gln Leu 
65                  70                  75                  80  


Pro Leu Gly Asp Arg Ser Glu Asn Arg Pro Pro Pro Lys 
                85                  90              

<210>  842
<211>  612
<212>  DNA
<213>  Homo sapiens

<400>  842
ggggaggtca acgggctatg ctggcttgac agggctgggc tcttcagaac agaagcatgg     60

atctcggaat ccctgacctg ctggacgcgt ggctggagcc cccagaggat atcttctcga    120

caggatccgt cctggagctg ggactccact gcccccctcc agaggttccg gtaactaggc    180

tacaggaaca gggactgcaa ggctggaagt ccggtgggga ccgtggctgt ggccttcaag    240

agagtgagcc tgaagatttc ttgaagcttt tcattgatcc caatgaggtg tactgctcag    300

aagcatctcc tggcagtgac agtggcatct ctgaggaccc ctgccatcca gacagtcccc    360

ctgcccccag ggcaaccagt tctcctatgc tctatgaggt tgtctatgag gcaggggccc    420

tggagaggat gcagggggaa actgggccaa atgtaggcct tatctccatc cagctaggtc    480

agtgttcttt gtgggaaggg ggaaatggcc cttcgggact ggccctaacc atggggttaa    540

gggggtttac ccaacctgtg ccactaccca ggccctgcgg ctgtcagggt gttcctaagt    600

ctcctttctc cc                                                        612


<210>  843
<211>  184
<212>  PRT
<213>  Homo sapiens

<400>  843


Met Asp Leu Gly Ile Pro Asp Leu Leu Asp Ala Trp Leu Glu Pro Pro 
1               5                   10                  15      


Glu Asp Ile Phe Ser Thr Gly Ser Val Leu Glu Leu Gly Leu His Cys 
            20                  25                  30          


Pro Pro Pro Glu Val Pro Val Thr Arg Leu Gln Glu Gln Gly Leu Gln 
        35                  40                  45              


Gly Trp Lys Ser Gly Gly Asp Arg Gly Cys Gly Leu Gln Glu Ser Glu 
    50                  55                  60                  


Pro Glu Asp Phe Leu Lys Leu Phe Ile Asp Pro Asn Glu Val Tyr Cys 
65                  70                  75                  80  


Ser Glu Ala Ser Pro Gly Ser Asp Ser Gly Ile Ser Glu Asp Pro Cys 
                85                  90                  95      


His Pro Asp Ser Pro Pro Ala Pro Arg Ala Thr Ser Ser Pro Met Leu 
            100                 105                 110         


Tyr Glu Val Val Tyr Glu Ala Gly Ala Leu Glu Arg Met Gln Gly Glu 
        115                 120                 125             


Thr Gly Pro Asn Val Gly Leu Ile Ser Ile Gln Leu Gly Gln Cys Ser 
    130                 135                 140                 


Leu Trp Glu Gly Gly Asn Gly Pro Ser Gly Leu Ala Leu Thr Met Gly 
145                 150                 155                 160 


Leu Arg Gly Phe Thr Gln Pro Val Pro Leu Pro Arg Pro Cys Gly Cys 
                165                 170                 175     


Gln Gly Val Pro Lys Ser Pro Phe 
            180                 

<210>  844
<211>  1654
<212>  DNA
<213>  Homo sapiens

<400>  844
tccacggggc tagatggctg cgtcgggggc gggagcggag gtgagcgggc gctagggccg     60

cgagcccccg ccggcccttc ctccagcgcc ctgcggaccc cgcagaaggc gctcgcctcc    120

ctagcccgca aaaacatatc gatttttctc gctgtggcaa cggggacgtc ctgatagatc    180

ctctgctcca ataggcaact ccggccttcc ctgccctgac ctggaacctc tgggagggct    240

gcagagtaag tgccgcctct gcgctccgac ggaggcacga ggcctgtgga gtaggtccct    300

ctgttccgac aggtgcgaca cttggcgctc catgcttgcg ggtgccggga ggcctggcct    360

cccccagggc cgccacctct gctggttgct ctgtgctttc accttaaagc tctggtaagg    420

aggaggtaag gggagggaaa aggaggtcac tggaggacag gatcgttccc ggcctcgggg    480

ctgggggaga tcttatccat ggacagcgca ggagggggtg ccctattttc tgggttttga    540

cttttgtccc ttcccccaac tccgctacag ccaagcagag gctcccgtgc aggaagagaa    600

gctgtcagaa aactacccct gagtgtggtc ccacaggata tgtagagaaa atcacatgca    660

gctcatctaa gagaaatgag ttcaaaagct gccgctcagc tttgatggaa caacgcttat    720

tttggaagtt cgaaggggct gtcgtgtgtg tggccctgat cttcgcttgt cttgtcatca    780

ttcgtcagcg acaattggac agaaaggctc tggaaaaggt ccggaagcaa atcgagtcca    840

tatagctaca ttccaccctt gtatcctggg tcttagagac cctatctcag acagtgaaag    900

tgaaatggac tgatttgcac tcttggttct ttggagcctt gtggtggaat ccccttttcc    960

ccatcttctt ctttcagatc attaatgagc agaataaaaa gagtaaaatg gtttccttcc   1020

cttctgtaac ttggagcagg aagtcatggg ggcagagagg gaaaggaggt ggttacttaa   1080

ggccccaatc taccaagtct tccccaccac ttctcccttg ttttccccct cttctactac   1140

ttatttcaaa cttctgggat acaatttcag ctaaaacgtt tatttctcac tcaaaactta   1200

tttcccctca accctatacc caaagaagaa ataaaatcac agatacataa cagaagtatt   1260

tgaggtaccc tctcatatat gcaaacaaat gcagactagg cctcaggcag agactaaagg   1320

acatctcttg gggtgtcctg aagtgatttg gacccctgag ggcagacacc taagtaggaa   1380

tcccagtggg aagcaaagcc ataaggaagc ccaggattcc ttgtgatcag gaagtgggcc   1440

aggaaggtct gttccagctc acatctcatc tgcatgcagc acggaccgga tgcgcccact   1500

gggtcttggc ttccctccca tcttctcaag cagtgtcctt gttgagccat ttgcatcctt   1560

ggctccaggt ggctccctca gtctggactc taccacttgg gtctccagat tttctgttac   1620

gtccttgtgg gtcaggatat ttctggaagt cact                               1654


<210>  845
<211>  80
<212>  PRT
<213>  Homo sapiens

<400>  845


Met Val Ser Phe Pro Ser Val Thr Trp Ser Arg Lys Ser Trp Gly Gln 
1               5                   10                  15      


Arg Gly Lys Gly Gly Gly Tyr Leu Arg Pro Gln Ser Thr Lys Ser Ser 
            20                  25                  30          


Pro Pro Leu Leu Pro Cys Phe Pro Pro Leu Leu Leu Leu Ile Ser Asn 
        35                  40                  45              


Phe Trp Asp Thr Ile Ser Ala Lys Thr Phe Ile Ser His Ser Lys Leu 
    50                  55                  60                  


Ile Ser Pro Gln Pro Tyr Thr Gln Arg Arg Asn Lys Ile Thr Asp Thr 
65                  70                  75                  80  

<210>  846
<211>  1503
<212>  DNA
<213>  Homo sapiens

<400>  846
tataagcccc agcgggcgac gaccgaacgc ccccgggaac accgggcccc gagctcggtc     60

ccgcgcccga ggatcctcca cggggctaga tggctgcgtc gggggcggga gcggaggcaa    120

ctccggcctt ccctgccctg acctggaacc tctgggaggg ctgcagagta agtgccgcct    180

ctgcgctccg acggaggcac gaggcctgtg gagtaggtcc ctctgttccg acaggtgcga    240

cacttggcgc tccatgcttg cgggtgccgg gaggcctggc ctcccccagg gccgccacct    300

ctgctggttg ctctgtgctt tcaccttaaa gctctgccaa gcagaggctc ccgtgcagga    360

agagaagctg tcagcaagca cctcaaattt gccatgctgg ctggtggaag agtttgtggt    420

agcagaagag tgctctccat gctctaattt ccgggctaaa actacccctg agtgtggtcc    480

cacaggatat gtagagaaaa tcacatgcag ctcatctaag agaaatgagt tcaaaagctg    540

ccgctcagct ttgatggaac aacgcttatt ttggaagttc gaaggggctg tcgtgtgtgt    600

ggccctgatc ttcgcttgtc ttgtcatcat tcgtcagcga caattggaca gaaaggctct    660

ggaaaaggtc cggaagcaaa tcgagtccat atagctacat tccacccttg tatcctgggt    720

cttagagacc ctatctcaga cagtgaaagt gaaatggact gatttgcact cttggttctt    780

tggagccttg tggtggaatc cccttttccc catcttcttc tttcagatca ttaatgagca    840

gaataaaaag agtaaaatgg tttccttccc ttctgtaact tggagcagga agtcatgggg    900

gcagagaggg aaaggaggtg gttacttaag gccccaatct accaagtctt ccccaccact    960

tctcccttgt tttccccctc ttctactact tatttcaaac ttctgggata caatttcagc   1020

taaaacgttt atttctcact caaaacttat ttcccctcaa ccctataccc aaagaagaaa   1080

taaaatcaca gatacataac agaagtattt gaggtaccct ctcatatatg caaacaaatg   1140

cagactaggc ctcaggcaga gactaaagga catctcttgg ggtgtcctga agtgatttgg   1200

acccctgagg gcagacacct aagtaggaat cccagtggga agcaaagcca taaggaagcc   1260

caggattcct tgtgatcagg aagtgggcca ggaaggtctg ttccagctca catctcatct   1320

gcatgcagca cggaccggat gcgcccactg ggtcttggct tccctcccat cttctcaagc   1380

agtgtccttg ttgagccatt tgcatccttg gctccaggtg gctccctcag tctggactct   1440

accacttggg tctccagatt ttctgttacg tccttgtggg tcaggatatt tctggaagtc   1500

act                                                                 1503


<210>  847
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  847


Met Leu Ala Gly Ala Gly Arg Pro Gly Leu Pro Gln Gly Arg His Leu 
1               5                   10                  15      


Cys Trp Leu Leu Cys Ala Phe Thr Leu Lys Leu Cys Gln Ala Glu Ala 
            20                  25                  30          


Pro Val Gln Glu Glu Lys Leu Ser Ala Ser Thr Ser Asn Leu Pro Cys 
        35                  40                  45              


Trp Leu Val Glu Glu Phe Val Val Ala Glu Glu Cys Ser Pro Cys Ser 
    50                  55                  60                  


Asn Phe Arg Ala Lys Thr Thr Pro Glu Cys Gly Pro Thr Gly Tyr Val 
65                  70                  75                  80  


Glu Lys Ile Thr Cys Ser Ser Ser Lys Arg Asn Glu Phe Lys Ser Cys 
                85                  90                  95      


Arg Ser Ala Leu Met Glu Gln Arg Leu Phe Trp Lys Phe Glu Gly Ala 
            100                 105                 110         


Val Val Cys Val Ala Leu Ile Phe Ala Cys Leu Val Ile Ile Arg Gln 
        115                 120                 125             


Arg Gln Leu Asp Arg Lys Ala Leu Glu Lys Val Arg Lys Gln Ile Glu 
    130                 135                 140                 


Ser Ile 
145     

<210>  848
<211>  1890
<212>  DNA
<213>  Homo sapiens

<400>  848
cggtggcgat gaaggggcgg ctggggaagg atgtcagaga aaccagaagc ttgacggtga     60

atcctcgggt tttaaggaga gagcaaagtc ctgagagggc gacgtattgt ccctgctcac    120

ctagcccaga atgaacaaac acgcgccagc cagggagcag cgagccgaga attcggacga    180

gcctctgcaa ccgccatttg ccgttctcgc aaagactacc aagaccacaa tgcaacgggg    240

cgccgagcta attcccagtg agcagcaggc gaggcgccac cgacgcggaa gactataagc    300

cccagcgggc gacgaccgaa cgcccccggg aacaccgggc cccgagctcg gtcccgcgcc    360

cgaggatcct ccacggggct agatggctgc gtcgggggcg ggagcggagg tgagcgggcg    420

ctagggccgc gagcccccgc cggcccttcc tccagcgccc tgcggacccc gcagaaggcg    480

ctcgcctccc tagcccgcaa aaacatatcg atttttctcg ctgtggcaac ggggacgtcc    540

tgatagatcc tctgctccaa taggcaactc cggccttccc tgccctgacc tggaacctct    600

gggagggctg cagatatctt ccccatatac caagagcaca ggtggaaaag gccggcacca    660

catggaatga gggcaagcgc tgtgccggga agttggatgg gcagagcctg ggagaaatgt    720

tttctgaatg gcctggggct ggcatttatc tttcctttca gcaagcacct caaatttgcc    780

atgctggctg gtggaagagt ttgtggtagc agaagagtgc tctccatgct ctaatttccg    840

ggctaaaact acccctgagt gtggtcccac aggatatgta gagaaaatca catgcagctc    900

atctaagaga aatgagttca aaagctgccg ctcagctttg atggaacaac gcttattttg    960

gaagttcgaa ggggctgtcg tgtgtgtggc cctgatcttc gcttgtcttg tcatcattcg   1020

tcagcgacaa ttggacagaa aggctctgga aaaggtccgg aagcaaatcg agtccatata   1080

gctacattcc acccttgtat cctgggtctt agagacccta tctcagacag tgaaagtgaa   1140

atggactgat ttgcactctt ggttctttgg agccttgtgg tggaatcccc ttttccccat   1200

cttcttcttt cagatcatta atgagcagaa taaaaagagt aaaatggttt ccttcccttc   1260

tgtaacttgg agcaggaagt catgggggca gagagggaaa ggaggtggtt acttaaggcc   1320

ccaatctacc aagtcttccc caccacttct cccttgtttt ccccctcttc tactacttat   1380

ttcaaacttc tgggatacaa tttcagctaa aacgtttatt tctcactcaa aacttatttc   1440

ccctcaaccc tatacccaaa gaagaaataa aatcacagat acataacaga agtatttgag   1500

gtaccctctc atatatgcaa acaaatgcag actaggcctc aggcagagac taaaggacat   1560

ctcttggggt gtcctgaagt gatttggacc cctgagggca gacacctaag taggaatccc   1620

agtgggaagc aaagccataa ggaagcccag gattccttgt gatcaggaag tgggccagga   1680

aggtctgttc cagctcacat ctcatctgca tgcagcacgg accggatgcg cccactgggt   1740

cttggcttcc ctcccatctt ctcaagcagt gtccttgttg agccatttgc atccttggct   1800

ccaggtggct ccctcagtct ggactctacc acttgggtct ccagattttc tgttacgtcc   1860

ttgtgggtca ggatatttct ggaagtcact                                    1890


<210>  849
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  849


Met Ala Trp Gly Trp His Leu Ser Phe Leu Ser Ala Ser Thr Ser Asn 
1               5                   10                  15      


Leu Pro Cys Trp Leu Val Glu Glu Phe Val Val Ala Glu Glu Cys Ser 
            20                  25                  30          


Pro Cys Ser Asn Phe Arg Ala Lys Thr Thr Pro Glu Cys Gly Pro Thr 
        35                  40                  45              


Gly Tyr Val Glu Lys Ile Thr Cys Ser Ser Ser Lys Arg Asn Glu Phe 
    50                  55                  60                  


Lys Ser Cys Arg Ser Ala Leu Met Glu Gln Arg Leu Phe Trp Lys Phe 
65                  70                  75                  80  


Glu Gly Ala Val Val Cys Val Ala Leu Ile Phe Ala Cys Leu Val Ile 
                85                  90                  95      


Ile Arg Gln Arg Gln Leu Asp Arg Lys Ala Leu Glu Lys Val Arg Lys 
            100                 105                 110         


Gln Ile Glu Ser Ile 
        115         

<210>  850
<211>  2502
<212>  DNA
<213>  Homo sapiens

<400>  850
ctttcctaag atcatggagt taataaccac cagaacctag actcaatact tatggaactt     60

caaatctcat gcttttctca ttgcacttat gattactcca ttatgtagga gcaagggaga    120

gttgagagca tttgaagagg ttatgcaaag gaccagctct gaggagtagg cttagcaaag    180

taacatgagg gaaggtaaca ccgttcatct gtgtagcgga gtgggagcca agagacaagg    240

agaaagtttc atgttcgtca tgtgtctcgg atattccggt ttctgcaggg acgagaacgc    300

gcagtttcgc ctccatccct tgacctccaa cacagcttct ccactggatc atcggtggcg    360

atgaaggggc ggctggggaa ggatgtcaga gaaaccagaa gcttgacggt gaatcctcgg    420

gttttaagga gagagcaaag tcctgagagg gcgacgtatt gtccctgctc acctagccca    480

gaatgaacaa acacgcgcca gccagggagc agcgagccga gaattcggac gagcctctgc    540

aaccgccatt tgccgttctc gcaaagacta ccaagaccac aatgcaacgg ggcgccgagc    600

taattcccag tgagcagcag gcgaggcgcc accgacgcgg aagactataa gccccagcgg    660

gcgacgaccg aacgcccccg ggaacaccgg gccccgagct cggtcccgcg cccgaggatc    720

ctccacgggg ctagatggct gcgtcggggg cgggagcgga ggtgagcggg cgctagggcc    780

gcgagccccc gccggccctt cctccagcgc cctgcggacc ccgcagaagg cgctcgcctc    840

cctagcccgc aaaaacatat cgatttttct cgctgtggca acggggacgt cctgatagat    900

cctctgctcc aataggcaac tccggccttc cctgccctga cctggaacct ctgggagggc    960

tgcagagtaa gtgccgcctc tgcgctccga cggaggcacg aggcctgtgg agtaggtccc   1020

tctgttccga caggtgcgac acttggcgct ccatgcttgc gggtgccggg aggcctggcc   1080

tcccccaggg ccgccacctc tgctggttgc tctgtgcttt caccttaaag ctctgccaag   1140

cagaggctcc cgtgcaggaa gagaagctgt caggtgggtg attgtctggg aacccgacac   1200

gtcccgtcgt ttgtttttgg ttttagtatc ttccccatat accaagagca caggtggaaa   1260

aggccggcac cacatggaat gagggcaagc gctgtgccgg gaagttggat gggcagagcc   1320

tgggagaaat gttttctgaa tggcctgggg ctggcattta tctttccttt cagcaagcac   1380

ctcaaatttg ccatgctggc tggtggaaga gtttgtggta gcagaagagt gctctccatg   1440

ctctaatttc cgggctaaaa ctacccctga gtgtggtccc acaggatatg tagagaaaat   1500

cacatgcagc tcatctaaga gaaatgagtt caaaagctgc cgctcagctt tgatggaaca   1560

acgcttattt tggaagttcg aaggggctgt cgtgtgtgtg gccctgatct tcgcttgtct   1620

tgtcatcatt cgtcagcgac aattggacag aaaggctctg gaaaaggtcc ggaagcaaat   1680

cgagtccata tagctacatt ccacccttgt atcctgggtc ttagagaccc tatctcagac   1740

agtgaaagtg aaatggactg atttgcactc ttggttcttt ggagccttgt ggtggaatcc   1800

ccttttcccc atcttcttct ttcagatcat taatgagcag aataaaaaga gtaaaatggt   1860

ttccttccct tctgtaactt ggagcaggaa gtcatggggg cagagaggga aaggaggtgg   1920

ttacttaagg ccccaatcta ccaagtcttc cccaccactt ctcccttgtt ttccccctct   1980

tctactactt atttcaaact tctgggatac aatttcagct aaaacgttta tttctcactc   2040

aaaacttatt tcccctcaac cctataccca aagaagaaat aaaatcacag atacataaca   2100

gaagtatttg aggtaccctc tcatatatgc aaacaaatgc agactaggcc tcaggcagag   2160

actaaaggac atctcttggg gtgtcctgaa gtgatttgga cccctgaggg cagacaccta   2220

agtaggaatc ccagtgggaa gcaaagccat aaggaagccc aggattcctt gtgatcagga   2280

agtgggccag gaaggtctgt tccagctcac atctcatctg catgcagcac ggaccggatg   2340

cgcccactgg gtcttggctt ccctcccatc ttctcaagca gtgtccttgt tgagccattt   2400

gcatccttgg ctccaggtgg ctccctcagt ctggactcta ccacttgggt ctccagattt   2460

tctgttacgt ccttgtgggt caggatattt ctggaagtca ct                      2502


<210>  851
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  851


Met Ala Trp Gly Trp His Leu Ser Phe Leu Ser Ala Ser Thr Ser Asn 
1               5                   10                  15      


Leu Pro Cys Trp Leu Val Glu Glu Phe Val Val Ala Glu Glu Cys Ser 
            20                  25                  30          


Pro Cys Ser Asn Phe Arg Ala Lys Thr Thr Pro Glu Cys Gly Pro Thr 
        35                  40                  45              


Gly Tyr Val Glu Lys Ile Thr Cys Ser Ser Ser Lys Arg Asn Glu Phe 
    50                  55                  60                  


Lys Ser Cys Arg Ser Ala Leu Met Glu Gln Arg Leu Phe Trp Lys Phe 
65                  70                  75                  80  


Glu Gly Ala Val Val Cys Val Ala Leu Ile Phe Ala Cys Leu Val Ile 
                85                  90                  95      


Ile Arg Gln Arg Gln Leu Asp Arg Lys Ala Leu Glu Lys Val Arg Lys 
            100                 105                 110         


Gln Ile Glu Ser Ile 
        115         

<210>  852
<211>  2219
<212>  DNA
<213>  Homo sapiens

<400>  852
ctttcctaag atcatggagt taataaccac cagaacctag actcaatact tatggaactt     60

caaatctcat gcttttctca ttgcacttat gattactcca ttatgtagga gcaagggaga    120

gttgagagca tttgaagagg ttatgcaaag gaccagctct gaggagtagg cttagcaaag    180

taacatgagg gaaggtaaca ccgttcatct gtgtagcgga gtgggagcca agagacaagg    240

agaaagtttc atgttcgtca tgtgtctcgg atattccggt ttctgcaggg acgagaacgc    300

gcagtttcgc ctccatccct tgacctccaa cacagcttct ccactggatc atcggtggcg    360

atgaaggggc ggctggggaa ggatgtcaga gaaaccagaa gcttgacggt gaatcctcgg    420

gttttaagga gagagcaaag tcctgagagg gcgacgtatt gtccctgctc acctagccca    480

gaatgaacaa acacgcgcca gccagggagc agcgagccga gaattcggac gagcctctgc    540

aaccgccatt tgccgttctc gcaaagacta ccaagaccac aatgcaacgg ggcgccgagc    600

taattcccag tgagcagcag gcgaggcgcc accgacgcgg aagactataa gccccagcgg    660

gcgacgaccg aacgcccccg ggaacaccgg gccccgagct cggtcccgcg cccgaggatc    720

ctccacgggg ctagatggct gcgtcggggg cgggagcgga ggtgagcggg cgctagggcc    780

gcgagccccc gccggccctt cctccagcgc cctgcggacc ccgcagaagg cgctcgcctc    840

cctagcccgc aaaaacatat cgatttttct cgctgtggca acggggacgt cctgatagat    900

cctctgctcc aataggcaac tccggccttc cctgccctga cctggaacct ctgggagggc    960

tgcagagtaa gtgccgcctc tgcgctccga cggaggcacg aggcctgtgg agtaggtccc   1020

tctgttccga caggtgcgac acttggcgct ccatgcttgc gggtgccggg aggcctggcc   1080

tcccccaggg ccgccacctc tgctggttgc tctgtgcttt caccttaaag ctctgccaag   1140

cagaggctcc cgtgcaggaa gagaagctgt cagaaaacta cccctgagtg tggtcccaca   1200

ggatatgtag agaaaatcac atgcagctca tctaagagaa atgagttcaa aagctgccgc   1260

tcagctttga tggaacaacg cttattttgg aagttcgaag gggctgtcgt gtgtgtggcc   1320

ctgatcttcg cttgtcttgt catcattcgt cagcgacaat tggacagaaa ggctctggaa   1380

aaggtccgga agcaaatcga gtccatatag ctacattcca cccttgtatc ctgggtctta   1440

gagaccctat ctcagacagt gaaagtgaaa tggactgatt tgcactcttg gttctttgga   1500

gccttgtggt ggaatcccct tttccccatc ttcttctttc agatcattaa tgagcagaat   1560

aaaaagagta aaatggtttc cttcccttct gtaacttgga gcaggaagtc atgggggcag   1620

agagggaaag gaggtggtta cttaaggccc caatctacca agtcttcccc accacttctc   1680

ccttgttttc cccctcttct actacttatt tcaaacttct gggatacaat ttcagctaaa   1740

acgtttattt ctcactcaaa acttatttcc cctcaaccct atacccaaag aagaaataaa   1800

atcacagata cataacagaa gtatttgagg taccctctca tatatgcaaa caaatgcaga   1860

ctaggcctca ggcagagact aaaggacatc tcttggggtg tcctgaagtg atttggaccc   1920

ctgagggcag acacctaagt aggaatccca gtgggaagca aagccataag gaagcccagg   1980

attccttgtg atcaggaagt gggccaggaa ggtctgttcc agctcacatc tcatctgcat   2040

gcagcacgga ccggatgcgc ccactgggtc ttggcttccc tcccatcttc tcaagcagtg   2100

tccttgttga gccatttgca tccttggctc caggtggctc cctcagtctg gactctacca   2160

cttgggtctc cagattttct gttacgtcct tgtgggtcag gatatttctg gaagtcact    2219


<210>  853
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  853


Met Leu Ala Gly Ala Gly Arg Pro Gly Leu Pro Gln Gly Arg His Leu 
1               5                   10                  15      


Cys Trp Leu Leu Cys Ala Phe Thr Leu Lys Leu Cys Gln Ala Glu Ala 
            20                  25                  30          


Pro Val Gln Glu Glu Lys Leu Ser Glu Asn Tyr Pro 
        35                  40                  

<210>  854
<211>  2302
<212>  DNA
<213>  Homo sapiens

<400>  854
ctttcctaag atcatggagt taataaccac cagaacctag actcaatact tatggaactt     60

caaatctcat gcttttctca ttgcacttat gattactcca ttatgtagga gcaagggaga    120

gttgagagca tttgaagagg ttatgcaaag gaccagctct gaggagtagg cttagcaaag    180

taacatgagg gaaggtaaca ccgttcatct gtgtagcgga gtgggagcca agagacaagg    240

agaaagtttc atgttcgtca tgtgtctcgg atattccggt ttctgcaggg acgagaacgc    300

gcagtttcgc ctccatccct tgacctccaa cacagcttct ccactggatc atcggtggcg    360

atgaaggggc ggctggggaa ggatgtcaga gaaaccagaa gcttgacggt gaatcctcgg    420

gttttaagga gagagcaaag tcctgagagg gcgacgtatt gtccctgctc acctagccca    480

gaatgaacaa acacgcgcca gccagggagc agcgagccga gaattcggac gagcctctgc    540

aaccgccatt tgccgttctc gcaaagacta ccaagaccac aatgcaacgg ggcgccgagc    600

taattcccag tgagcagcag gcgaggcgcc accgacgcgg aagactataa gccccagcgg    660

gcgacgaccg aacgcccccg ggaacaccgg gccccgagct cggtcccgcg cccgaggatc    720

ctccacgggg ctagatggct gcgtcggggg cgggagcgga ggtgagcggg cgctagggcc    780

gcgagccccc gccggccctt cctccagcgc cctgcggacc ccgcagaagg cgctcgcctc    840

cctagcccgc aaaaacatat cgatttttct cgctgtggca acggggacgt cctgatagat    900

cctctgctcc aataggcaac tccggccttc cctgccctga cctggaacct ctgggagggc    960

tgcagagtaa gtgccgcctc tgcgctccga cggaggcacg aggcctgtgg agtaggtccc   1020

tctgttccga caggtgcgac acttggcgct ccatgcttgc gggtgccggg aggcctggcc   1080

tcccccaggg ccgccacctc tgctggttgc tctgtgcttt caccttaaag ctctgccaag   1140

cagaggctcc cgtgcaggaa gagaagctgt cagcaagcac ctcaaatttg ccatgctggc   1200

tggtggaaga gtttgtggta gcagaagagt gctctccatg ctctaatttc cgggctaaaa   1260

ctacccctga gtgtggtccc acaggatatg tagagaaaat cacatgcagc tcatctaaga   1320

gaaatgagtt caaaagctgc cgctcagctt tgatggaaca acgcttattt tggaagttcg   1380

aaggggctgt cgtgtgtgtg gccctgatct tcgcttgtct tgtcatcatt cgtcagcgac   1440

aattggacag aaaggctctg gaaaaggtcc ggaagcaaat cgagtccata tagctacatt   1500

ccacccttgt atcctgggtc ttagagaccc tatctcagac agtgaaagtg aaatggactg   1560

atttgcactc ttggttcttt ggagccttgt ggtggaatcc ccttttcccc atcttcttct   1620

ttcagatcat taatgagcag aataaaaaga gtaaaatggt ttccttccct tctgtaactt   1680

ggagcaggaa gtcatggggg cagagaggga aaggaggtgg ttacttaagg ccccaatcta   1740

ccaagtcttc cccaccactt ctcccttgtt ttccccctct tctactactt atttcaaact   1800

tctgggatac aatttcagct aaaacgttta tttctcactc aaaacttatt tcccctcaac   1860

cctataccca aagaagaaat aaaatcacag atacataaca gaagtatttg aggtaccctc   1920

tcatatatgc aaacaaatgc agactaggcc tcaggcagag actaaaggac atctcttggg   1980

gtgtcctgaa gtgatttgga cccctgaggg cagacaccta agtaggaatc ccagtgggaa   2040

gcaaagccat aaggaagccc aggattcctt gtgatcagga agtgggccag gaaggtctgt   2100

tccagctcac atctcatctg catgcagcac ggaccggatg cgcccactgg gtcttggctt   2160

ccctcccatc ttctcaagca gtgtccttgt tgagccattt gcatccttgg ctccaggtgg   2220

ctccctcagt ctggactcta ccacttgggt ctccagattt tctgttacgt ccttgtgggt   2280

caggatattt ctggaagtca ct                                            2302


<210>  855
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  855


Met Leu Ala Gly Ala Gly Arg Pro Gly Leu Pro Gln Gly Arg His Leu 
1               5                   10                  15      


Cys Trp Leu Leu Cys Ala Phe Thr Leu Lys Leu Cys Gln Ala Glu Ala 
            20                  25                  30          


Pro Val Gln Glu Glu Lys Leu Ser Ala Ser Thr Ser Asn Leu Pro Cys 
        35                  40                  45              


Trp Leu Val Glu Glu Phe Val Val Ala Glu Glu Cys Ser Pro Cys Ser 
    50                  55                  60                  


Asn Phe Arg Ala Lys Thr Thr Pro Glu Cys Gly Pro Thr Gly Tyr Val 
65                  70                  75                  80  


Glu Lys Ile Thr Cys Ser Ser Ser Lys Arg Asn Glu Phe Lys Ser Cys 
                85                  90                  95      


Arg Ser Ala Leu Met Glu Gln Arg Leu Phe Trp Lys Phe Glu Gly Ala 
            100                 105                 110         


Val Val Cys Val Ala Leu Ile Phe Ala Cys Leu Val Ile Ile Arg Gln 
        115                 120                 125             


Arg Gln Leu Asp Arg Lys Ala Leu Glu Lys Val Arg Lys Gln Ile Glu 
    130                 135                 140                 


Ser Ile 
145     

<210>  856
<211>  1257
<212>  DNA
<213>  Homo sapiens

<400>  856
tccacggggc tagatggctg cgtcgggggc gggagcggag gtgagcgggc gctagggccg     60

cgagcccccg ccggcccttc ctccagcgcc ctgcggaccc cgcagaaggc gctcgcctcc    120

ctagcccgca aaaacatatc gatttttctc gctgtggcaa cggggacgtc ctgatagatc    180

ctctgctcca ataggcaact ccggccttcc ctgccctgac ctggaacctc tgggagggct    240

gcagagtaag tgccgcctct gcgctccgac ggaggcacga ggcctgtgga gtaggtccct    300

ctgttccgac aggtgcgaca cttggcgctc catgcttgcg ggtgccggga ggcctggcct    360

cccccagggc cgccacctct gctggttgct ctgtgctttc accttaaagc tctggtaagg    420

aggaggtaag gggagggaaa aggaggtcac tggaggacag gatcgttccc ggcctcgggg    480

ctgggggaga tcttatccat ggacagcgca ggagggggtg ccctattttc tgggttttga    540

cttttgtccc ttcccccaac tccgctacag ccaagcagag gctcccgtgc aggaagagaa    600

gctgtcagaa aactacccct gagtgtggtc ccacaggata tgtagagaaa atcacatgca    660

gctcatctaa gagaaatgag ttcaaaagct gccgctcagc tttgatggaa caacgcttat    720

tttggaagtt cgaaggggct gtcgtgtgtg tggccctgat cttcgcttgt cttgtcatca    780

ttcgtcagcg acaattggac agaaaggctc tggaaaaggt ccggaagcaa atcgagtcca    840

tatagctaca ttccaccctt gtatcctggg tcttagagac cctatctcag acagtgaaag    900

tgaaatggac tgatttgcac tcttggttct ttggagcctt gtggtggaat ccccttttcc    960

ccatcttctt ctttcagatc attaatgagc agaataaaaa gagtaaaatg gtttccttcc   1020

cttctgtaac ttggagcagg aagtcatggg ggcagagagg gaaaggaggt ggttacttaa   1080

ggccccaatc taccaagtct tccccaccac ttctcccttg ttttccccct cttctactac   1140

ttatttcaaa cttctgggat acaatttcag ctaaaacgtt tatttctcac tcaaaactta   1200

tttcccctca accctatacc caaagaagaa ataaaatcac agatacataa cagaagt      1257


<210>  857
<211>  80
<212>  PRT
<213>  Homo sapiens

<400>  857


Met Val Ser Phe Pro Ser Val Thr Trp Ser Arg Lys Ser Trp Gly Gln 
1               5                   10                  15      


Arg Gly Lys Gly Gly Gly Tyr Leu Arg Pro Gln Ser Thr Lys Ser Ser 
            20                  25                  30          


Pro Pro Leu Leu Pro Cys Phe Pro Pro Leu Leu Leu Leu Ile Ser Asn 
        35                  40                  45              


Phe Trp Asp Thr Ile Ser Ala Lys Thr Phe Ile Ser His Ser Lys Leu 
    50                  55                  60                  


Ile Ser Pro Gln Pro Tyr Thr Gln Arg Arg Asn Lys Ile Thr Asp Thr 
65                  70                  75                  80  

<210>  858
<211>  1106
<212>  DNA
<213>  Homo sapiens

<400>  858
tataagcccc agcgggcgac gaccgaacgc ccccgggaac accgggcccc gagctcggtc     60

ccgcgcccga ggatcctcca cggggctaga tggctgcgtc gggggcggga gcggaggcaa    120

ctccggcctt ccctgccctg acctggaacc tctgggaggg ctgcagagta agtgccgcct    180

ctgcgctccg acggaggcac gaggcctgtg gagtaggtcc ctctgttccg acaggtgcga    240

cacttggcgc tccatgcttg cgggtgccgg gaggcctggc ctcccccagg gccgccacct    300

ctgctggttg ctctgtgctt tcaccttaaa gctctgccaa gcagaggctc ccgtgcagga    360

agagaagctg tcagcaagca cctcaaattt gccatgctgg ctggtggaag agtttgtggt    420

agcagaagag tgctctccat gctctaattt ccgggctaaa actacccctg agtgtggtcc    480

cacaggatat gtagagaaaa tcacatgcag ctcatctaag agaaatgagt tcaaaagctg    540

ccgctcagct ttgatggaac aacgcttatt ttggaagttc gaaggggctg tcgtgtgtgt    600

ggccctgatc ttcgcttgtc ttgtcatcat tcgtcagcga caattggaca gaaaggctct    660

ggaaaaggtc cggaagcaaa tcgagtccat atagctacat tccacccttg tatcctgggt    720

cttagagacc ctatctcaga cagtgaaagt gaaatggact gatttgcact cttggttctt    780

tggagccttg tggtggaatc cccttttccc catcttcttc tttcagatca ttaatgagca    840

gaataaaaag agtaaaatgg tttccttccc ttctgtaact tggagcagga agtcatgggg    900

gcagagaggg aaaggaggtg gttacttaag gccccaatct accaagtctt ccccaccact    960

tctcccttgt tttccccctc ttctactact tatttcaaac ttctgggata caatttcagc   1020

taaaacgttt atttctcact caaaacttat ttcccctcaa ccctataccc aaagaagaaa   1080

taaaatcaca gatacataac agaagt                                        1106


<210>  859
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  859


Met Leu Ala Gly Ala Gly Arg Pro Gly Leu Pro Gln Gly Arg His Leu 
1               5                   10                  15      


Cys Trp Leu Leu Cys Ala Phe Thr Leu Lys Leu Cys Gln Ala Glu Ala 
            20                  25                  30          


Pro Val Gln Glu Glu Lys Leu Ser Ala Ser Thr Ser Asn Leu Pro Cys 
        35                  40                  45              


Trp Leu Val Glu Glu Phe Val Val Ala Glu Glu Cys Ser Pro Cys Ser 
    50                  55                  60                  


Asn Phe Arg Ala Lys Thr Thr Pro Glu Cys Gly Pro Thr Gly Tyr Val 
65                  70                  75                  80  


Glu Lys Ile Thr Cys Ser Ser Ser Lys Arg Asn Glu Phe Lys Ser Cys 
                85                  90                  95      


Arg Ser Ala Leu Met Glu Gln Arg Leu Phe Trp Lys Phe Glu Gly Ala 
            100                 105                 110         


Val Val Cys Val Ala Leu Ile Phe Ala Cys Leu Val Ile Ile Arg Gln 
        115                 120                 125             


Arg Gln Leu Asp Arg Lys Ala Leu Glu Lys Val Arg Lys Gln Ile Glu 
    130                 135                 140                 


Ser Ile 
145     

<210>  860
<211>  1493
<212>  DNA
<213>  Homo sapiens

<400>  860
cggtggcgat gaaggggcgg ctggggaagg atgtcagaga aaccagaagc ttgacggtga     60

atcctcgggt tttaaggaga gagcaaagtc ctgagagggc gacgtattgt ccctgctcac    120

ctagcccaga atgaacaaac acgcgccagc cagggagcag cgagccgaga attcggacga    180

gcctctgcaa ccgccatttg ccgttctcgc aaagactacc aagaccacaa tgcaacgggg    240

cgccgagcta attcccagtg agcagcaggc gaggcgccac cgacgcggaa gactataagc    300

cccagcgggc gacgaccgaa cgcccccggg aacaccgggc cccgagctcg gtcccgcgcc    360

cgaggatcct ccacggggct agatggctgc gtcgggggcg ggagcggagg tgagcgggcg    420

ctagggccgc gagcccccgc cggcccttcc tccagcgccc tgcggacccc gcagaaggcg    480

ctcgcctccc tagcccgcaa aaacatatcg atttttctcg ctgtggcaac ggggacgtcc    540

tgatagatcc tctgctccaa taggcaactc cggccttccc tgccctgacc tggaacctct    600

gggagggctg cagatatctt ccccatatac caagagcaca ggtggaaaag gccggcacca    660

catggaatga gggcaagcgc tgtgccggga agttggatgg gcagagcctg ggagaaatgt    720

tttctgaatg gcctggggct ggcatttatc tttcctttca gcaagcacct caaatttgcc    780

atgctggctg gtggaagagt ttgtggtagc agaagagtgc tctccatgct ctaatttccg    840

ggctaaaact acccctgagt gtggtcccac aggatatgta gagaaaatca catgcagctc    900

atctaagaga aatgagttca aaagctgccg ctcagctttg atggaacaac gcttattttg    960

gaagttcgaa ggggctgtcg tgtgtgtggc cctgatcttc gcttgtcttg tcatcattcg   1020

tcagcgacaa ttggacagaa aggctctgga aaaggtccgg aagcaaatcg agtccatata   1080

gctacattcc acccttgtat cctgggtctt agagacccta tctcagacag tgaaagtgaa   1140

atggactgat ttgcactctt ggttctttgg agccttgtgg tggaatcccc ttttccccat   1200

cttcttcttt cagatcatta atgagcagaa taaaaagagt aaaatggttt ccttcccttc   1260

tgtaacttgg agcaggaagt catgggggca gagagggaaa ggaggtggtt acttaaggcc   1320

ccaatctacc aagtcttccc caccacttct cccttgtttt ccccctcttc tactacttat   1380

ttcaaacttc tgggatacaa tttcagctaa aacgtttatt tctcactcaa aacttatttc   1440

ccctcaaccc tatacccaaa gaagaaataa aatcacagat acataacaga agt          1493


<210>  861
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  861


Met Ala Trp Gly Trp His Leu Ser Phe Leu Ser Ala Ser Thr Ser Asn 
1               5                   10                  15      


Leu Pro Cys Trp Leu Val Glu Glu Phe Val Val Ala Glu Glu Cys Ser 
            20                  25                  30          


Pro Cys Ser Asn Phe Arg Ala Lys Thr Thr Pro Glu Cys Gly Pro Thr 
        35                  40                  45              


Gly Tyr Val Glu Lys Ile Thr Cys Ser Ser Ser Lys Arg Asn Glu Phe 
    50                  55                  60                  


Lys Ser Cys Arg Ser Ala Leu Met Glu Gln Arg Leu Phe Trp Lys Phe 
65                  70                  75                  80  


Glu Gly Ala Val Val Cys Val Ala Leu Ile Phe Ala Cys Leu Val Ile 
                85                  90                  95      


Ile Arg Gln Arg Gln Leu Asp Arg Lys Ala Leu Glu Lys Val Arg Lys 
            100                 105                 110         


Gln Ile Glu Ser Ile 
        115         

<210>  862
<211>  1905
<212>  DNA
<213>  Homo sapiens

<400>  862
ctttcctaag atcatggagt taataaccac cagaacctag actcaatact tatggaactt     60

caaatctcat gcttttctca ttgcacttat gattactcca ttatgtagga gcaagggaga    120

gttgagagca tttgaagagg ttatgcaaag gaccagctct gaggagtagg cttagcaaag    180

taacatgagg gaaggtaaca ccgttcatct gtgtagcgga gtgggagcca agagacaagg    240

agaaagtttc atgttcgtca tgtgtctcgg atattccggt ttctgcaggg acgagaacgc    300

gcagtttcgc ctccatccct tgacctccaa cacagcttct ccactggatc atcggtggcg    360

atgaaggggc ggctggggaa ggatgtcaga gaaaccagaa gcttgacggt gaatcctcgg    420

gttttaagga gagagcaaag tcctgagagg gcgacgtatt gtccctgctc acctagccca    480

gaatgaacaa acacgcgcca gccagggagc agcgagccga gaattcggac gagcctctgc    540

aaccgccatt tgccgttctc gcaaagacta ccaagaccac aatgcaacgg ggcgccgagc    600

taattcccag tgagcagcag gcgaggcgcc accgacgcgg aagactataa gccccagcgg    660

gcgacgaccg aacgcccccg ggaacaccgg gccccgagct cggtcccgcg cccgaggatc    720

ctccacgggg ctagatggct gcgtcggggg cgggagcgga ggtgagcggg cgctagggcc    780

gcgagccccc gccggccctt cctccagcgc cctgcggacc ccgcagaagg cgctcgcctc    840

cctagcccgc aaaaacatat cgatttttct cgctgtggca acggggacgt cctgatagat    900

cctctgctcc aataggcaac tccggccttc cctgccctga cctggaacct ctgggagggc    960

tgcagagtaa gtgccgcctc tgcgctccga cggaggcacg aggcctgtgg agtaggtccc   1020

tctgttccga caggtgcgac acttggcgct ccatgcttgc gggtgccggg aggcctggcc   1080

tcccccaggg ccgccacctc tgctggttgc tctgtgcttt caccttaaag ctctgccaag   1140

cagaggctcc cgtgcaggaa gagaagctgt cagcaagcac ctcaaatttg ccatgctggc   1200

tggtggaaga gtttgtggta gcagaagagt gctctccatg ctctaatttc cgggctaaaa   1260

ctacccctga gtgtggtccc acaggatatg tagagaaaat cacatgcagc tcatctaaga   1320

gaaatgagtt caaaagctgc cgctcagctt tgatggaaca acgcttattt tggaagttcg   1380

aaggggctgt cgtgtgtgtg gccctgatct tcgcttgtct tgtcatcatt cgtcagcgac   1440

aattggacag aaaggctctg gaaaaggtcc ggaagcaaat cgagtccata tagctacatt   1500

ccacccttgt atcctgggtc ttagagaccc tatctcagac agtgaaagtg aaatggactg   1560

atttgcactc ttggttcttt ggagccttgt ggtggaatcc ccttttcccc atcttcttct   1620

ttcagatcat taatgagcag aataaaaaga gtaaaatggt ttccttccct tctgtaactt   1680

ggagcaggaa gtcatggggg cagagaggga aaggaggtgg ttacttaagg ccccaatcta   1740

ccaagtcttc cccaccactt ctcccttgtt ttccccctct tctactactt atttcaaact   1800

tctgggatac aatttcagct aaaacgttta tttctcactc aaaacttatt tcccctcaac   1860

cctataccca aagaagaaat aaaatcacag atacataaca gaagt                   1905


<210>  863
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  863


Met Leu Ala Gly Ala Gly Arg Pro Gly Leu Pro Gln Gly Arg His Leu 
1               5                   10                  15      


Cys Trp Leu Leu Cys Ala Phe Thr Leu Lys Leu Cys Gln Ala Glu Ala 
            20                  25                  30          


Pro Val Gln Glu Glu Lys Leu Ser Ala Ser Thr Ser Asn Leu Pro Cys 
        35                  40                  45              


Trp Leu Val Glu Glu Phe Val Val Ala Glu Glu Cys Ser Pro Cys Ser 
    50                  55                  60                  


Asn Phe Arg Ala Lys Thr Thr Pro Glu Cys Gly Pro Thr Gly Tyr Val 
65                  70                  75                  80  


Glu Lys Ile Thr Cys Ser Ser Ser Lys Arg Asn Glu Phe Lys Ser Cys 
                85                  90                  95      


Arg Ser Ala Leu Met Glu Gln Arg Leu Phe Trp Lys Phe Glu Gly Ala 
            100                 105                 110         


Val Val Cys Val Ala Leu Ile Phe Ala Cys Leu Val Ile Ile Arg Gln 
        115                 120                 125             


Arg Gln Leu Asp Arg Lys Ala Leu Glu Lys Val Arg Lys Gln Ile Glu 
    130                 135                 140                 


Ser Ile 
145     

<210>  864
<211>  1822
<212>  DNA
<213>  Homo sapiens

<400>  864
ctttcctaag atcatggagt taataaccac cagaacctag actcaatact tatggaactt     60

caaatctcat gcttttctca ttgcacttat gattactcca ttatgtagga gcaagggaga    120

gttgagagca tttgaagagg ttatgcaaag gaccagctct gaggagtagg cttagcaaag    180

taacatgagg gaaggtaaca ccgttcatct gtgtagcgga gtgggagcca agagacaagg    240

agaaagtttc atgttcgtca tgtgtctcgg atattccggt ttctgcaggg acgagaacgc    300

gcagtttcgc ctccatccct tgacctccaa cacagcttct ccactggatc atcggtggcg    360

atgaaggggc ggctggggaa ggatgtcaga gaaaccagaa gcttgacggt gaatcctcgg    420

gttttaagga gagagcaaag tcctgagagg gcgacgtatt gtccctgctc acctagccca    480

gaatgaacaa acacgcgcca gccagggagc agcgagccga gaattcggac gagcctctgc    540

aaccgccatt tgccgttctc gcaaagacta ccaagaccac aatgcaacgg ggcgccgagc    600

taattcccag tgagcagcag gcgaggcgcc accgacgcgg aagactataa gccccagcgg    660

gcgacgaccg aacgcccccg ggaacaccgg gccccgagct cggtcccgcg cccgaggatc    720

ctccacgggg ctagatggct gcgtcggggg cgggagcgga ggtgagcggg cgctagggcc    780

gcgagccccc gccggccctt cctccagcgc cctgcggacc ccgcagaagg cgctcgcctc    840

cctagcccgc aaaaacatat cgatttttct cgctgtggca acggggacgt cctgatagat    900

cctctgctcc aataggcaac tccggccttc cctgccctga cctggaacct ctgggagggc    960

tgcagagtaa gtgccgcctc tgcgctccga cggaggcacg aggcctgtgg agtaggtccc   1020

tctgttccga caggtgcgac acttggcgct ccatgcttgc gggtgccggg aggcctggcc   1080

tcccccaggg ccgccacctc tgctggttgc tctgtgcttt caccttaaag ctctgccaag   1140

cagaggctcc cgtgcaggaa gagaagctgt cagaaaacta cccctgagtg tggtcccaca   1200

ggatatgtag agaaaatcac atgcagctca tctaagagaa atgagttcaa aagctgccgc   1260

tcagctttga tggaacaacg cttattttgg aagttcgaag gggctgtcgt gtgtgtggcc   1320

ctgatcttcg cttgtcttgt catcattcgt cagcgacaat tggacagaaa ggctctggaa   1380

aaggtccgga agcaaatcga gtccatatag ctacattcca cccttgtatc ctgggtctta   1440

gagaccctat ctcagacagt gaaagtgaaa tggactgatt tgcactcttg gttctttgga   1500

gccttgtggt ggaatcccct tttccccatc ttcttctttc agatcattaa tgagcagaat   1560

aaaaagagta aaatggtttc cttcccttct gtaacttgga gcaggaagtc atgggggcag   1620

agagggaaag gaggtggtta cttaaggccc caatctacca agtcttcccc accacttctc   1680

ccttgttttc cccctcttct actacttatt tcaaacttct gggatacaat ttcagctaaa   1740

acgtttattt ctcactcaaa acttatttcc cctcaaccct atacccaaag aagaaataaa   1800

atcacagata cataacagaa gt                                            1822


<210>  865
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  865


Met Leu Ala Gly Ala Gly Arg Pro Gly Leu Pro Gln Gly Arg His Leu 
1               5                   10                  15      


Cys Trp Leu Leu Cys Ala Phe Thr Leu Lys Leu Cys Gln Ala Glu Ala 
            20                  25                  30          


Pro Val Gln Glu Glu Lys Leu Ser Glu Asn Tyr Pro 
        35                  40                  

<210>  866
<211>  2105
<212>  DNA
<213>  Homo sapiens

<400>  866
ctttcctaag atcatggagt taataaccac cagaacctag actcaatact tatggaactt     60

caaatctcat gcttttctca ttgcacttat gattactcca ttatgtagga gcaagggaga    120

gttgagagca tttgaagagg ttatgcaaag gaccagctct gaggagtagg cttagcaaag    180

taacatgagg gaaggtaaca ccgttcatct gtgtagcgga gtgggagcca agagacaagg    240

agaaagtttc atgttcgtca tgtgtctcgg atattccggt ttctgcaggg acgagaacgc    300

gcagtttcgc ctccatccct tgacctccaa cacagcttct ccactggatc atcggtggcg    360

atgaaggggc ggctggggaa ggatgtcaga gaaaccagaa gcttgacggt gaatcctcgg    420

gttttaagga gagagcaaag tcctgagagg gcgacgtatt gtccctgctc acctagccca    480

gaatgaacaa acacgcgcca gccagggagc agcgagccga gaattcggac gagcctctgc    540

aaccgccatt tgccgttctc gcaaagacta ccaagaccac aatgcaacgg ggcgccgagc    600

taattcccag tgagcagcag gcgaggcgcc accgacgcgg aagactataa gccccagcgg    660

gcgacgaccg aacgcccccg ggaacaccgg gccccgagct cggtcccgcg cccgaggatc    720

ctccacgggg ctagatggct gcgtcggggg cgggagcgga ggtgagcggg cgctagggcc    780

gcgagccccc gccggccctt cctccagcgc cctgcggacc ccgcagaagg cgctcgcctc    840

cctagcccgc aaaaacatat cgatttttct cgctgtggca acggggacgt cctgatagat    900

cctctgctcc aataggcaac tccggccttc cctgccctga cctggaacct ctgggagggc    960

tgcagagtaa gtgccgcctc tgcgctccga cggaggcacg aggcctgtgg agtaggtccc   1020

tctgttccga caggtgcgac acttggcgct ccatgcttgc gggtgccggg aggcctggcc   1080

tcccccaggg ccgccacctc tgctggttgc tctgtgcttt caccttaaag ctctgccaag   1140

cagaggctcc cgtgcaggaa gagaagctgt caggtgggtg attgtctggg aacccgacac   1200

gtcccgtcgt ttgtttttgg ttttagtatc ttccccatat accaagagca caggtggaaa   1260

aggccggcac cacatggaat gagggcaagc gctgtgccgg gaagttggat gggcagagcc   1320

tgggagaaat gttttctgaa tggcctgggg ctggcattta tctttccttt cagcaagcac   1380

ctcaaatttg ccatgctggc tggtggaaga gtttgtggta gcagaagagt gctctccatg   1440

ctctaatttc cgggctaaaa ctacccctga gtgtggtccc acaggatatg tagagaaaat   1500

cacatgcagc tcatctaaga gaaatgagtt caaaagctgc cgctcagctt tgatggaaca   1560

acgcttattt tggaagttcg aaggggctgt cgtgtgtgtg gccctgatct tcgcttgtct   1620

tgtcatcatt cgtcagcgac aattggacag aaaggctctg gaaaaggtcc ggaagcaaat   1680

cgagtccata tagctacatt ccacccttgt atcctgggtc ttagagaccc tatctcagac   1740

agtgaaagtg aaatggactg atttgcactc ttggttcttt ggagccttgt ggtggaatcc   1800

ccttttcccc atcttcttct ttcagatcat taatgagcag aataaaaaga gtaaaatggt   1860

ttccttccct tctgtaactt ggagcaggaa gtcatggggg cagagaggga aaggaggtgg   1920

ttacttaagg ccccaatcta ccaagtcttc cccaccactt ctcccttgtt ttccccctct   1980

tctactactt atttcaaact tctgggatac aatttcagct aaaacgttta tttctcactc   2040

aaaacttatt tcccctcaac cctataccca aagaagaaat aaaatcacag atacataaca   2100

gaagt                                                               2105


<210>  867
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  867


Met Ala Trp Gly Trp His Leu Ser Phe Leu Ser Ala Ser Thr Ser Asn 
1               5                   10                  15      


Leu Pro Cys Trp Leu Val Glu Glu Phe Val Val Ala Glu Glu Cys Ser 
            20                  25                  30          


Pro Cys Ser Asn Phe Arg Ala Lys Thr Thr Pro Glu Cys Gly Pro Thr 
        35                  40                  45              


Gly Tyr Val Glu Lys Ile Thr Cys Ser Ser Ser Lys Arg Asn Glu Phe 
    50                  55                  60                  


Lys Ser Cys Arg Ser Ala Leu Met Glu Gln Arg Leu Phe Trp Lys Phe 
65                  70                  75                  80  


Glu Gly Ala Val Val Cys Val Ala Leu Ile Phe Ala Cys Leu Val Ile 
                85                  90                  95      


Ile Arg Gln Arg Gln Leu Asp Arg Lys Ala Leu Glu Lys Val Arg Lys 
            100                 105                 110         


Gln Ile Glu Ser Ile 
        115         

<210>  868
<211>  1027
<212>  DNA
<213>  Homo sapiens

<400>  868
tccacggggc tagatggctg cgtcgggggc gggagcggag gtgagcgggc gctagggccg     60

cgagcccccg ccggcccttc ctccagcgcc ctgcggaccc cgcagaaggc gctcgcctcc    120

ctagcccgca aaaacatatc gatttttctc gctgtggcaa cggggacgtc ctgatagatc    180

ctctgctcca ataggcaact ccggccttcc ctgccctgac ctggaacctc tgggagggct    240

gcagagtaag tgccgcctct gcgctccgac ggaggcacga ggcctgtgga gtaggtccct    300

ctgttccgac aggtgcgaca cttggcgctc catgcttgcg ggtgccggga ggcctggcct    360

cccccagggc cgccacctct gctggttgct ctgtgctttc accttaaagc tctggtaagg    420

aggaggtaag gggagggaaa aggaggtcac tggaggacag gatcgttccc ggcctcgggg    480

ctgggggaga tcttatccat ggacagcgca ggagggggtg ccctattttc tgggttttga    540

cttttgtccc ttcccccaac tccgctacag ccaagcagag gctcccgtgc aggaagagaa    600

gctgtcagaa aactacccct gagtgtggtc ccacaggata tgtagagaaa atcacatgca    660

gctcatctaa gagaaatgag ttcaaaagct gccgctcagc tttgatggaa caacgcttat    720

tttggaagtt cgaaggggct gtcgtgtgtg tggccctgat cttcgcttgt cttgtcatca    780

ttcgtcagcg acaattggac agaaaggctc tggaaaaggt ccggaagcaa atcgagtcca    840

tatagctaca ttccaccctt gtatcctggg tcttagagac cctatctcag acagtgaaag    900

tgaaatggac tgatttgcac tcttggttct ttggagcctt gtggtggaat ccccttttcc    960

ccatcttctt ctttcagatc attaatgagc agaataaaaa gagtaaaatg gtttccttcc   1020

cttctgt                                                             1027


<210>  869
<211>  46
<212>  PRT
<213>  Homo sapiens

<400>  869


Met Glu Gln Arg Leu Phe Trp Lys Phe Glu Gly Ala Val Val Cys Val 
1               5                   10                  15      


Ala Leu Ile Phe Ala Cys Leu Val Ile Ile Arg Gln Arg Gln Leu Asp 
            20                  25                  30          


Arg Lys Ala Leu Glu Lys Val Arg Lys Gln Ile Glu Ser Ile 
        35                  40                  45      

<210>  870
<211>  1055
<212>  DNA
<213>  Homo sapiens

<400>  870
accgaacgcc cccgggaaca ccgggccccg agctcggtcc cgcgcccgag gatcctccac     60

ggggctagat ggctgcgtcg ggggcgggag cggaggcaac tccggccttc cctgccctga    120

cctggaacct ctgggagggc tgcagagtaa gtgccgcctc tgcgctccga cggaggcacg    180

aggcctgtgg agtaggtccc tctgttccga caggtgcgac acttggcgct ccatgcttgc    240

gggtgccggg aggcctggcc tcccccaggg ccgccacctc tgctggttgc tctgtgcttt    300

caccttaaag ctctgccaag cagaggctcc cgtgcaggaa gagaagctgt caggtgggtg    360

attgtctggg aacccgacac gtcccgtcgt ttgtttttgg ttttagtatc ttccccatat    420

accaagagca caggtggaaa aggccggcac cacatggaat gagggcaagc gctgtgccgg    480

gaagttggat gggcagagcc tgggagaaat gttttctgaa tggcctgggg ctggcattta    540

tctttccttt cagcaagcac ctcaaatttg ccatgctggc tggtggaaga gtttgtggta    600

gcagaagagt gctctccatg ctctaatttc cgggctaaaa ctacccctga gtgtggtccc    660

acaggatatg tagagaaaat cacatgcagc tcatctaaga gaaatgagtt caaaagctgc    720

cgctcagctt tgatggaaca acgcttattt tggaagttcg aaggggctgt cgtgtgtgtg    780

gccctgatct tcgcttgtct tgtcatcatt cgtcagcgac aattggacag aaaggctctg    840

gaaaaggtcc ggaagcaaat cgagtccata tagctacatt ccacccttgt atcctgggtc    900

ttagagaccc tatctcagac agtgaaagtg aaatggactg atttgcactc ttggttcttt    960

ggagccttgt ggtggaatcc ccttttcccc atcttcttct ttcagatcat taatgagcag   1020

aataaaaaga gtaaaatggt ttccttccct tctgt                              1055


<210>  871
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  871


Met Ala Trp Gly Trp His Leu Ser Phe Leu Ser Ala Ser Thr Ser Asn 
1               5                   10                  15      


Leu Pro Cys Trp Leu Val Glu Glu Phe Val Val Ala Glu Glu Cys Ser 
            20                  25                  30          


Pro Cys Ser Asn Phe Arg Ala Lys Thr Thr Pro Glu Cys Gly Pro Thr 
        35                  40                  45              


Gly Tyr Val Glu Lys Ile Thr Cys Ser Ser Ser Lys Arg Asn Glu Phe 
    50                  55                  60                  


Lys Ser Cys Arg Ser Ala Leu Met Glu Gln Arg Leu Phe Trp Lys Phe 
65                  70                  75                  80  


Glu Gly Ala Val Val Cys Val Ala Leu Ile Phe Ala Cys Leu Val Ile 
                85                  90                  95      


Ile Arg Gln Arg Gln Leu Asp Arg Lys Ala Leu Glu Lys Val Arg Lys 
            100                 105                 110         


Gln Ile Glu Ser Ile 
        115         

<210>  872
<211>  876
<212>  DNA
<213>  Homo sapiens

<400>  872
tataagcccc agcgggcgac gaccgaacgc ccccgggaac accgggcccc gagctcggtc     60

ccgcgcccga ggatcctcca cggggctaga tggctgcgtc gggggcggga gcggaggcaa    120

ctccggcctt ccctgccctg acctggaacc tctgggaggg ctgcagagta agtgccgcct    180

ctgcgctccg acggaggcac gaggcctgtg gagtaggtcc ctctgttccg acaggtgcga    240

cacttggcgc tccatgcttg cgggtgccgg gaggcctggc ctcccccagg gccgccacct    300

ctgctggttg ctctgtgctt tcaccttaaa gctctgccaa gcagaggctc ccgtgcagga    360

agagaagctg tcagcaagca cctcaaattt gccatgctgg ctggtggaag agtttgtggt    420

agcagaagag tgctctccat gctctaattt ccgggctaaa actacccctg agtgtggtcc    480

cacaggatat gtagagaaaa tcacatgcag ctcatctaag agaaatgagt tcaaaagctg    540

ccgctcagct ttgatggaac aacgcttatt ttggaagttc gaaggggctg tcgtgtgtgt    600

ggccctgatc ttcgcttgtc ttgtcatcat tcgtcagcga caattggaca gaaaggctct    660

ggaaaaggtc cggaagcaaa tcgagtccat atagctacat tccacccttg tatcctgggt    720

cttagagacc ctatctcaga cagtgaaagt gaaatggact gatttgcact cttggttctt    780

tggagccttg tggtggaatc cccttttccc catcttcttc tttcagatca ttaatgagca    840

gaataaaaag agtaaaatgg tttccttccc ttctgt                              876


<210>  873
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  873


Met Leu Ala Gly Ala Gly Arg Pro Gly Leu Pro Gln Gly Arg His Leu 
1               5                   10                  15      


Cys Trp Leu Leu Cys Ala Phe Thr Leu Lys Leu Cys Gln Ala Glu Ala 
            20                  25                  30          


Pro Val Gln Glu Glu Lys Leu Ser Ala Ser Thr Ser Asn Leu Pro Cys 
        35                  40                  45              


Trp Leu Val Glu Glu Phe Val Val Ala Glu Glu Cys Ser Pro Cys Ser 
    50                  55                  60                  


Asn Phe Arg Ala Lys Thr Thr Pro Glu Cys Gly Pro Thr Gly Tyr Val 
65                  70                  75                  80  


Glu Lys Ile Thr Cys Ser Ser Ser Lys Arg Asn Glu Phe Lys Ser Cys 
                85                  90                  95      


Arg Ser Ala Leu Met Glu Gln Arg Leu Phe Trp Lys Phe Glu Gly Ala 
            100                 105                 110         


Val Val Cys Val Ala Leu Ile Phe Ala Cys Leu Val Ile Ile Arg Gln 
        115                 120                 125             


Arg Gln Leu Asp Arg Lys Ala Leu Glu Lys Val Arg Lys Gln Ile Glu 
    130                 135                 140                 


Ser Ile 
145     

<210>  874
<211>  1263
<212>  DNA
<213>  Homo sapiens

<400>  874
cggtggcgat gaaggggcgg ctggggaagg atgtcagaga aaccagaagc ttgacggtga     60

atcctcgggt tttaaggaga gagcaaagtc ctgagagggc gacgtattgt ccctgctcac    120

ctagcccaga atgaacaaac acgcgccagc cagggagcag cgagccgaga attcggacga    180

gcctctgcaa ccgccatttg ccgttctcgc aaagactacc aagaccacaa tgcaacgggg    240

cgccgagcta attcccagtg agcagcaggc gaggcgccac cgacgcggaa gactataagc    300

cccagcgggc gacgaccgaa cgcccccggg aacaccgggc cccgagctcg gtcccgcgcc    360

cgaggatcct ccacggggct agatggctgc gtcgggggcg ggagcggagg tgagcgggcg    420

ctagggccgc gagcccccgc cggcccttcc tccagcgccc tgcggacccc gcagaaggcg    480

ctcgcctccc tagcccgcaa aaacatatcg atttttctcg ctgtggcaac ggggacgtcc    540

tgatagatcc tctgctccaa taggcaactc cggccttccc tgccctgacc tggaacctct    600

gggagggctg cagatatctt ccccatatac caagagcaca ggtggaaaag gccggcacca    660

catggaatga gggcaagcgc tgtgccggga agttggatgg gcagagcctg ggagaaatgt    720

tttctgaatg gcctggggct ggcatttatc tttcctttca gcaagcacct caaatttgcc    780

atgctggctg gtggaagagt ttgtggtagc agaagagtgc tctccatgct ctaatttccg    840

ggctaaaact acccctgagt gtggtcccac aggatatgta gagaaaatca catgcagctc    900

atctaagaga aatgagttca aaagctgccg ctcagctttg atggaacaac gcttattttg    960

gaagttcgaa ggggctgtcg tgtgtgtggc cctgatcttc gcttgtcttg tcatcattcg   1020

tcagcgacaa ttggacagaa aggctctgga aaaggtccgg aagcaaatcg agtccatata   1080

gctacattcc acccttgtat cctgggtctt agagacccta tctcagacag tgaaagtgaa   1140

atggactgat ttgcactctt ggttctttgg agccttgtgg tggaatcccc ttttccccat   1200

cttcttcttt cagatcatta atgagcagaa taaaaagagt aaaatggttt ccttcccttc   1260

tgt                                                                 1263


<210>  875
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  875


Met Ala Trp Gly Trp His Leu Ser Phe Leu Ser Ala Ser Thr Ser Asn 
1               5                   10                  15      


Leu Pro Cys Trp Leu Val Glu Glu Phe Val Val Ala Glu Glu Cys Ser 
            20                  25                  30          


Pro Cys Ser Asn Phe Arg Ala Lys Thr Thr Pro Glu Cys Gly Pro Thr 
        35                  40                  45              


Gly Tyr Val Glu Lys Ile Thr Cys Ser Ser Ser Lys Arg Asn Glu Phe 
    50                  55                  60                  


Lys Ser Cys Arg Ser Ala Leu Met Glu Gln Arg Leu Phe Trp Lys Phe 
65                  70                  75                  80  


Glu Gly Ala Val Val Cys Val Ala Leu Ile Phe Ala Cys Leu Val Ile 
                85                  90                  95      


Ile Arg Gln Arg Gln Leu Asp Arg Lys Ala Leu Glu Lys Val Arg Lys 
            100                 105                 110         


Gln Ile Glu Ser Ile 
        115         

<210>  876
<211>  1592
<212>  DNA
<213>  Homo sapiens

<400>  876
ctttcctaag atcatggagt taataaccac cagaacctag actcaatact tatggaactt     60

caaatctcat gcttttctca ttgcacttat gattactcca ttatgtagga gcaagggaga    120

gttgagagca tttgaagagg ttatgcaaag gaccagctct gaggagtagg cttagcaaag    180

taacatgagg gaaggtaaca ccgttcatct gtgtagcgga gtgggagcca agagacaagg    240

agaaagtttc atgttcgtca tgtgtctcgg atattccggt ttctgcaggg acgagaacgc    300

gcagtttcgc ctccatccct tgacctccaa cacagcttct ccactggatc atcggtggcg    360

atgaaggggc ggctggggaa ggatgtcaga gaaaccagaa gcttgacggt gaatcctcgg    420

gttttaagga gagagcaaag tcctgagagg gcgacgtatt gtccctgctc acctagccca    480

gaatgaacaa acacgcgcca gccagggagc agcgagccga gaattcggac gagcctctgc    540

aaccgccatt tgccgttctc gcaaagacta ccaagaccac aatgcaacgg ggcgccgagc    600

taattcccag tgagcagcag gcgaggcgcc accgacgcgg aagactataa gccccagcgg    660

gcgacgaccg aacgcccccg ggaacaccgg gccccgagct cggtcccgcg cccgaggatc    720

ctccacgggg ctagatggct gcgtcggggg cgggagcgga ggtgagcggg cgctagggcc    780

gcgagccccc gccggccctt cctccagcgc cctgcggacc ccgcagaagg cgctcgcctc    840

cctagcccgc aaaaacatat cgatttttct cgctgtggca acggggacgt cctgatagat    900

cctctgctcc aataggcaac tccggccttc cctgccctga cctggaacct ctgggagggc    960

tgcagagtaa gtgccgcctc tgcgctccga cggaggcacg aggcctgtgg agtaggtccc   1020

tctgttccga caggtgcgac acttggcgct ccatgcttgc gggtgccggg aggcctggcc   1080

tcccccaggg ccgccacctc tgctggttgc tctgtgcttt caccttaaag ctctgccaag   1140

cagaggctcc cgtgcaggaa gagaagctgt cagaaaacta cccctgagtg tggtcccaca   1200

ggatatgtag agaaaatcac atgcagctca tctaagagaa atgagttcaa aagctgccgc   1260

tcagctttga tggaacaacg cttattttgg aagttcgaag gggctgtcgt gtgtgtggcc   1320

ctgatcttcg cttgtcttgt catcattcgt cagcgacaat tggacagaaa ggctctggaa   1380

aaggtccgga agcaaatcga gtccatatag ctacattcca cccttgtatc ctgggtctta   1440

gagaccctat ctcagacagt gaaagtgaaa tggactgatt tgcactcttg gttctttgga   1500

gccttgtggt ggaatcccct tttccccatc ttcttctttc agatcattaa tgagcagaat   1560

aaaaagagta aaatggtttc cttcccttct gt                                 1592


<210>  877
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  877


Met Leu Ala Gly Ala Gly Arg Pro Gly Leu Pro Gln Gly Arg His Leu 
1               5                   10                  15      


Cys Trp Leu Leu Cys Ala Phe Thr Leu Lys Leu Cys Gln Ala Glu Ala 
            20                  25                  30          


Pro Val Gln Glu Glu Lys Leu Ser Glu Asn Tyr Pro 
        35                  40                  

<210>  878
<211>  1675
<212>  DNA
<213>  Homo sapiens

<400>  878
ctttcctaag atcatggagt taataaccac cagaacctag actcaatact tatggaactt     60

caaatctcat gcttttctca ttgcacttat gattactcca ttatgtagga gcaagggaga    120

gttgagagca tttgaagagg ttatgcaaag gaccagctct gaggagtagg cttagcaaag    180

taacatgagg gaaggtaaca ccgttcatct gtgtagcgga gtgggagcca agagacaagg    240

agaaagtttc atgttcgtca tgtgtctcgg atattccggt ttctgcaggg acgagaacgc    300

gcagtttcgc ctccatccct tgacctccaa cacagcttct ccactggatc atcggtggcg    360

atgaaggggc ggctggggaa ggatgtcaga gaaaccagaa gcttgacggt gaatcctcgg    420

gttttaagga gagagcaaag tcctgagagg gcgacgtatt gtccctgctc acctagccca    480

gaatgaacaa acacgcgcca gccagggagc agcgagccga gaattcggac gagcctctgc    540

aaccgccatt tgccgttctc gcaaagacta ccaagaccac aatgcaacgg ggcgccgagc    600

taattcccag tgagcagcag gcgaggcgcc accgacgcgg aagactataa gccccagcgg    660

gcgacgaccg aacgcccccg ggaacaccgg gccccgagct cggtcccgcg cccgaggatc    720

ctccacgggg ctagatggct gcgtcggggg cgggagcgga ggtgagcggg cgctagggcc    780

gcgagccccc gccggccctt cctccagcgc cctgcggacc ccgcagaagg cgctcgcctc    840

cctagcccgc aaaaacatat cgatttttct cgctgtggca acggggacgt cctgatagat    900

cctctgctcc aataggcaac tccggccttc cctgccctga cctggaacct ctgggagggc    960

tgcagagtaa gtgccgcctc tgcgctccga cggaggcacg aggcctgtgg agtaggtccc   1020

tctgttccga caggtgcgac acttggcgct ccatgcttgc gggtgccggg aggcctggcc   1080

tcccccaggg ccgccacctc tgctggttgc tctgtgcttt caccttaaag ctctgccaag   1140

cagaggctcc cgtgcaggaa gagaagctgt cagcaagcac ctcaaatttg ccatgctggc   1200

tggtggaaga gtttgtggta gcagaagagt gctctccatg ctctaatttc cgggctaaaa   1260

ctacccctga gtgtggtccc acaggatatg tagagaaaat cacatgcagc tcatctaaga   1320

gaaatgagtt caaaagctgc cgctcagctt tgatggaaca acgcttattt tggaagttcg   1380

aaggggctgt cgtgtgtgtg gccctgatct tcgcttgtct tgtcatcatt cgtcagcgac   1440

aattggacag aaaggctctg gaaaaggtcc ggaagcaaat cgagtccata tagctacatt   1500

ccacccttgt atcctgggtc ttagagaccc tatctcagac agtgaaagtg aaatggactg   1560

atttgcactc ttggttcttt ggagccttgt ggtggaatcc ccttttcccc atcttcttct   1620

ttcagatcat taatgagcag aataaaaaga gtaaaatggt ttccttccct tctgt        1675


<210>  879
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  879


Met Leu Ala Gly Ala Gly Arg Pro Gly Leu Pro Gln Gly Arg His Leu 
1               5                   10                  15      


Cys Trp Leu Leu Cys Ala Phe Thr Leu Lys Leu Cys Gln Ala Glu Ala 
            20                  25                  30          


Pro Val Gln Glu Glu Lys Leu Ser Ala Ser Thr Ser Asn Leu Pro Cys 
        35                  40                  45              


Trp Leu Val Glu Glu Phe Val Val Ala Glu Glu Cys Ser Pro Cys Ser 
    50                  55                  60                  


Asn Phe Arg Ala Lys Thr Thr Pro Glu Cys Gly Pro Thr Gly Tyr Val 
65                  70                  75                  80  


Glu Lys Ile Thr Cys Ser Ser Ser Lys Arg Asn Glu Phe Lys Ser Cys 
                85                  90                  95      


Arg Ser Ala Leu Met Glu Gln Arg Leu Phe Trp Lys Phe Glu Gly Ala 
            100                 105                 110         


Val Val Cys Val Ala Leu Ile Phe Ala Cys Leu Val Ile Ile Arg Gln 
        115                 120                 125             


Arg Gln Leu Asp Arg Lys Ala Leu Glu Lys Val Arg Lys Gln Ile Glu 
    130                 135                 140                 


Ser Ile 
145     

<210>  880
<211>  1875
<212>  DNA
<213>  Homo sapiens

<400>  880
ctttcctaag atcatggagt taataaccac cagaacctag actcaatact tatggaactt     60

caaatctcat gcttttctca ttgcacttat gattactcca ttatgtagga gcaagggaga    120

gttgagagca tttgaagagg ttatgcaaag gaccagctct gaggagtagg cttagcaaag    180

taacatgagg gaaggtaaca ccgttcatct gtgtagcgga gtgggagcca agagacaagg    240

agaaagtttc atgttcgtca tgtgtctcgg atattccggt ttctgcaggg acgagaacgc    300

gcagtttcgc ctccatccct tgacctccaa cacagcttct ccactggatc atcggtggcg    360

atgaaggggc ggctggggaa ggatgtcaga gaaaccagaa gcttgacggt gaatcctcgg    420

gttttaagga gagagcaaag tcctgagagg gcgacgtatt gtccctgctc acctagccca    480

gaatgaacaa acacgcgcca gccagggagc agcgagccga gaattcggac gagcctctgc    540

aaccgccatt tgccgttctc gcaaagacta ccaagaccac aatgcaacgg ggcgccgagc    600

taattcccag tgagcagcag gcgaggcgcc accgacgcgg aagactataa gccccagcgg    660

gcgacgaccg aacgcccccg ggaacaccgg gccccgagct cggtcccgcg cccgaggatc    720

ctccacgggg ctagatggct gcgtcggggg cgggagcgga ggtgagcggg cgctagggcc    780

gcgagccccc gccggccctt cctccagcgc cctgcggacc ccgcagaagg cgctcgcctc    840

cctagcccgc aaaaacatat cgatttttct cgctgtggca acggggacgt cctgatagat    900

cctctgctcc aataggcaac tccggccttc cctgccctga cctggaacct ctgggagggc    960

tgcagagtaa gtgccgcctc tgcgctccga cggaggcacg aggcctgtgg agtaggtccc   1020

tctgttccga caggtgcgac acttggcgct ccatgcttgc gggtgccggg aggcctggcc   1080

tcccccaggg ccgccacctc tgctggttgc tctgtgcttt caccttaaag ctctgccaag   1140

cagaggctcc cgtgcaggaa gagaagctgt caggtgggtg attgtctggg aacccgacac   1200

gtcccgtcgt ttgtttttgg ttttagtatc ttccccatat accaagagca caggtggaaa   1260

aggccggcac cacatggaat gagggcaagc gctgtgccgg gaagttggat gggcagagcc   1320

tgggagaaat gttttctgaa tggcctgggg ctggcattta tctttccttt cagcaagcac   1380

ctcaaatttg ccatgctggc tggtggaaga gtttgtggta gcagaagagt gctctccatg   1440

ctctaatttc cgggctaaaa ctacccctga gtgtggtccc acaggatatg tagagaaaat   1500

cacatgcagc tcatctaaga gaaatgagtt caaaagctgc cgctcagctt tgatggaaca   1560

acgcttattt tggaagttcg aaggggctgt cgtgtgtgtg gccctgatct tcgcttgtct   1620

tgtcatcatt cgtcagcgac aattggacag aaaggctctg gaaaaggtcc ggaagcaaat   1680

cgagtccata tagctacatt ccacccttgt atcctgggtc ttagagaccc tatctcagac   1740

agtgaaagtg aaatggactg atttgcactc ttggttcttt ggagccttgt ggtggaatcc   1800

ccttttcccc atcttcttct ttcagatcat taatgagcag aataaaaaga gtaaaatggt   1860

ttccttccct tctgt                                                    1875


<210>  881
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  881


Met Ala Trp Gly Trp His Leu Ser Phe Leu Ser Ala Ser Thr Ser Asn 
1               5                   10                  15      


Leu Pro Cys Trp Leu Val Glu Glu Phe Val Val Ala Glu Glu Cys Ser 
            20                  25                  30          


Pro Cys Ser Asn Phe Arg Ala Lys Thr Thr Pro Glu Cys Gly Pro Thr 
        35                  40                  45              


Gly Tyr Val Glu Lys Ile Thr Cys Ser Ser Ser Lys Arg Asn Glu Phe 
    50                  55                  60                  


Lys Ser Cys Arg Ser Ala Leu Met Glu Gln Arg Leu Phe Trp Lys Phe 
65                  70                  75                  80  


Glu Gly Ala Val Val Cys Val Ala Leu Ile Phe Ala Cys Leu Val Ile 
                85                  90                  95      


Ile Arg Gln Arg Gln Leu Asp Arg Lys Ala Leu Glu Lys Val Arg Lys 
            100                 105                 110         


Gln Ile Glu Ser Ile 
        115         

<210>  882
<211>  1182
<212>  DNA
<213>  Homo sapiens

<400>  882
ctttcctaag atcatggagt taataaccac cagaacctag actcaatact tatggaactt     60

caaatctcat gcttttctca ttgcacttat gattactcca ttatgtagga gcaagggaga    120

gttgagagca tttgaagagg ttatgcaaag gaccagctct gaggagtagg cttagcaaag    180

taacatgagg gaaggtaaca ccgttcatct gtgtagcgga gtgggagcca agagacaagg    240

agaaagtttc atgttcgtca tgtgtctcgg atattccggt ttctgcaggg acgagaacgc    300

gcagtttcgc ctccatccct tgacctccaa cacagcttct ccactggatc atcggtggcg    360

atgaaggggc ggctggggaa ggatgtcaga gaaaccagaa gcttgacggt gaatcctcgg    420

gttttaagga gagagcaaag tcctgagagg gcgacgtatt gtccctgctc acctagccca    480

gaatgaacaa acacgcgcca gccagggagc agcgagccga gaattcggac gagcctctgc    540

aaccgccatt tgccgttctc gcaaagacta ccaagaccac aatgcaacgg ggcgccgagc    600

taattcccag tgagcagcag gcgaggcgcc accgacgcgg aagactataa gccccagcgg    660

gcgacgaccg aacgcccccg ggaacaccgg gccccgagct cggtcccgcg cccgaggatc    720

ctccacgggg ctagatggct gcgtcggggg cgggagcgga ggtgagcggg cgctagggcc    780

gcgagccccc gccggccctt cctccagcgc cctgcggacc ccgcagaagg cgctcgcctc    840

cctagcccgc aaaaacatat cgatttttct cgctgtggca acggggacgt cctgatagat    900

cctctgctcc aataggcaac tccggccttc cctgccctga cctggaacct ctgggagggc    960

tgcagagtaa gtgccgcctc tgcgctccga cggaggcacg aggcctgtgg agtaggtccc   1020

tctgttccga cagtgctttc accttaaagc tctggtaagg aggaggtaag gggagggaaa   1080

aggaggtcac tggaggacag gatcgttccc ggcctcgggg ctgggggaga tcttatccat   1140

ggacagcgca ggagggggtg ccctattttc tgggttttga ct                      1182


<210>  883
<211>  59
<212>  PRT
<213>  Homo sapiens

<400>  883


Met Arg Glu Gly Asn Thr Val His Leu Cys Ser Gly Val Gly Ala Lys 
1               5                   10                  15      


Arg Gln Gly Glu Ser Phe Met Phe Val Met Cys Leu Gly Tyr Ser Gly 
            20                  25                  30          


Phe Cys Arg Asp Glu Asn Ala Gln Phe Arg Leu His Pro Leu Thr Ser 
        35                  40                  45              


Asn Thr Ala Ser Pro Leu Asp His Arg Trp Arg 
    50                  55                  

<210>  884
<211>  1159
<212>  DNA
<213>  Homo sapiens

<400>  884
ctttcctaag atcatggagt taataaccac cagaacctag actcaatact tatggaactt     60

caaatctcat gcttttctca ttgcacttat gattactcca ttatgtagga gcaagggaga    120

gttgagagca tttgaagagg ttatgcaaag gaccagctct gaggagtagg cttagcaaag    180

taacatgagg gaaggtaaca ccgttcatct gtgtagcgga gtgggagcca agagacaagg    240

agaaagtttc atgttcgtca tgtgtctcgg atattccggt ttctgcaggg acgagaacgc    300

gcagtttcgc ctccatccct tgacctccaa cacagcttct ccactggatc atcggtggcg    360

atgaaggggc ggctggggaa ggatgtcaga gaaaccagaa gcttgacggt gaatcctcgg    420

gttttaagga gagagcaaag tcctgagagg gcgacgtatt gtccctgctc acctagccca    480

gaatgaacaa acacgcgcca gccagggagc agcgagccga gaattcggac gagcctctgc    540

aaccgccatt tgccgttctc gcaaagacta ccaagaccac aatgcaacgg ggcgccgagc    600

taattcccag tgagcagcag gcgaggcgcc accgacgcgg aagactataa gccccagcgg    660

gcgacgaccg aacgcccccg ggaacaccgg gccccgagct cggtcccgcg cccgaggatc    720

ctccacgggg ctagatggct gcgtcggggg cgggagcgga ggtgagcggg cgctagggcc    780

gcgagccccc gccggccctt cctccagcgc cctgcggacc ccgcagaagg cgctcgcctc    840

cctagcccgc aaaaacatat cgatttttct cgctgtggca acggggacgt cctgatagat    900

cctctgctcc aataggcaac tccggccttc cctgccctga cctggaacct ctgggagggc    960

tgcagagtaa gtgccgcctc tgcgctccga cggaggcacg aggcctgtgg agtaggtccc   1020

tctgttccga caggtgcgac acttggcgct ccatgcttgc gggtgccggg aggcctggcc   1080

tcccccaggg ccgccacctc tgctggttgc tctgtgtggg ggagatctta tccatggaca   1140

gcgcaggagg gggtgccct                                                1159


<210>  885
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  885


Met Leu Ala Gly Ala Gly Arg Pro Gly Leu Pro Gln Gly Arg His Leu 
1               5                   10                  15      


Cys Trp Leu Leu Cys Val Gly Glu Ile Leu Ser Met Asp Ser Ala Gly 
            20                  25                  30          


Gly Gly 
        

<210>  886
<211>  368
<212>  DNA
<213>  Homo sapiens

<400>  886
gccccagcgg gcgacgaccg aacgcccccg ggaacaccgg gccccgagct cggtcccgcg     60

cccgaggatc ctccacgggg ctagatggct gcgtcggggg cgggagcgga ggcaactccg    120

gccttccctg ccctgacctg gaacctctgg gagggctgca gagtaagtgc cgcctctgcg    180

ctccgacgga ggcacgaggc ctgtggagta ggtccctctg ttccgacagg tgcgacactt    240

ggcgctccat gcttgcgggt gccgggaggc ctggcctccc ccagggccgc cacctctgct    300

ggttgctctg tgctttcacc ttaaagctct ggtaaggagg aggtaagggg agggaaaagg    360

aggtcact                                                             368


<210>  887
<211>  79
<212>  PRT
<213>  Homo sapiens

<400>  887


Met Ala Ala Ser Gly Ala Gly Ala Glu Ala Thr Pro Ala Phe Pro Ala 
1               5                   10                  15      


Leu Thr Trp Asn Leu Trp Glu Gly Cys Arg Val Ser Ala Ala Ser Ala 
            20                  25                  30          


Leu Arg Arg Arg His Glu Ala Cys Gly Val Gly Pro Ser Val Pro Thr 
        35                  40                  45              


Gly Ala Thr Leu Gly Ala Pro Cys Leu Arg Val Pro Gly Gly Leu Ala 
    50                  55                  60                  


Ser Pro Arg Ala Ala Thr Ser Ala Gly Cys Ser Val Leu Ser Pro 
65                  70                  75                  

<210>  888
<211>  1301
<212>  DNA
<213>  Homo sapiens

<400>  888
ctctttcccg gagcctgggc ggagagggag gaaaacttct tcctggcctg ggctccgtgc     60

cgctctgttt gccaaccgtc cagtcccgcc taccagtgcc gggcgctccc cacccctccc    120

ccggctcccc cggtgtccgc catggccaaa gcctacgacc acctcttcaa gttgctgctg    180

atcggggact cgggggtggg caagacttgt ctgatcattc gctttgcaga ggacaacttc    240

aacaacactt acatctccac catcggtgag cccgctggcc atgtcccaga ccccgactct    300

cctgtgacct ccttctccgg ctcccggatt actagtgacc ccacttttca gtccccttag    360

agaattgatt tcaagatccg cactgtggat atagagggga agaagatcaa actacaagtc    420

tgggacacgg ctggccaaga gcggttcaag acaataacta ctgcctacta ccgtggagcc    480

atgggcatta tcctagtata cgacatcacg gatgagaaat ctttcgagaa tattcagaac    540

tggatgaaaa gcatcaagga gaatgcctcg gctggggtgg agcgcctctt gctggggaac    600

aaatgtgaca tggaggccaa gaggaaggtg cagaaggagc aggccgataa gttggctcga    660

gagcatggaa tccgattttt cgaaactagt gctaaatcca gtatgaatgt ggatgaggct    720

tttagttccc tggcccggga catcttgctc aagtcaggag gccggagatc aggaaacggc    780

aacaagcctc ccagtactga cctgaaaact tgtgacaaga agaacaccaa caagtgctcc    840

ctgggctgag gaccctttct tgcctcccca ccccggaagc tgaacctgag ggagacaacg    900

gcagagggag tgagcagggg agaaatagca gaggggcttg gagggtcaca taggtagatg    960

gtaaagagaa tgaggagaaa aaggagaaaa gggaaaagca gaaaggaaaa aaaggaagag   1020

agaggaaggg agaagggaga ggaatgaatt gaggaagtga aagaaggcaa ggaggtagga   1080

agagagggag gaggaaagga aggagagatg cctcaggctt cagaccttac ctgggttttc   1140

agggcaaaca taaatgtaaa tacactgatt tattctgtta ctagatcagg ttttagggtc   1200

ctgcaaaagg ctagctcggc actacactag ggaatttgct cctgttctgt cacttgtcat   1260

ggtctttctt ggtattaaag gccaccattt gcacaaatgt t                       1301


<210>  889
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  889


Met Gly Ile Ile Leu Val Tyr Asp Ile Thr Asp Glu Lys Ser Phe Glu 
1               5                   10                  15      


Asn Ile Gln Asn Trp Met Lys Ser Ile Lys Glu Asn Ala Ser Ala Gly 
            20                  25                  30          


Val Glu Arg Leu Leu Leu Gly Asn Lys Cys Asp Met Glu Ala Lys Arg 
        35                  40                  45              


Lys Val Gln Lys Glu Gln Ala Asp Lys Leu Ala Arg Glu His Gly Ile 
    50                  55                  60                  


Arg Phe Phe Glu Thr Ser Ala Lys Ser Ser Met Asn Val Asp Glu Ala 
65                  70                  75                  80  


Phe Ser Ser Leu Ala Arg Asp Ile Leu Leu Lys Ser Gly Gly Arg Arg 
                85                  90                  95      


Ser Gly Asn Gly Asn Lys Pro Pro Ser Thr Asp Leu Lys Thr Cys Asp 
            100                 105                 110         


Lys Lys Asn Thr Asn Lys Cys Ser Leu Gly 
        115                 120         

<210>  890
<211>  1205
<212>  DNA
<213>  Homo sapiens

<400>  890
ctctttcccg gagcctgggc ggagagggag gaaaacttct tcctggcctg ggctccgtgc     60

cgctctgttt gccaaccgtc cagtcccgcc taccagtgcc gggcgctccc cacccctccc    120

ccggctcccc cggtgtccgc catggccaaa gcctacgacc acctcttcaa gttgctgctg    180

atcggggact cgggggtggg caagacttgt ctgatcattc gctttgcaga ggacaacttc    240

aacaacactt acatctccac catcggaatt gatttcaaga tccgcactgt ggatatagag    300

gggaagaaga tcaaactaca agtctgggac acggctggcc aagagcggtt caagacaata    360

actactgcct actaccgtgg agccatgggc attatcctag tatacgacat cacggatgag    420

aaatctttcg agaatattca gaactggatg aaaagcatca aggagaatgc ctcggctggg    480

gtggagcgcc tcttgctggg gaacaaatgt gacatggagg ccaagaggaa ggtgcagaag    540

gagcaggccg ataagttggc tcgagagcat ggaatccgat ttttcgaaac tagtgctaaa    600

tccagtatga atgtggatga ggcttttagt tccctggccc gggacatctt gctcaagtca    660

ggaggccgga gatcaggaaa cggcaacaag cctcccagta ctgacctgaa aacttgtgac    720

aagaagaaca ccaacaagtg ctccctgggc tgaggaccct ttcttgcctc cccaccccgg    780

aagctgaacc tgagggagac aacggcagag ggagtgagca ggggagaaat agcagagggg    840

cttggagggt cacataggta gatggtaaag agaatgagga gaaaaaggag aaaagggaaa    900

agcagaaagg aaaaaaagga agagagagga agggagaagg gagaggaatg aattgaggaa    960

gtgaaagaag gcaaggaggt aggaagagag ggaggaggaa aggaaggaga gatgcctcag   1020

gcttcagacc ttacctgggt tttcagggca aacataaatg taaatacact gatttattct   1080

gttactagat caggttttag ggtcctgcaa aaggctagct cggcactaca ctagggaatt   1140

tgctcctgtt ctgtcacttg tcatggtctt tcttggtatt aaaggccacc atttgcacaa   1200

atgtt                                                               1205


<210>  891
<211>  203
<212>  PRT
<213>  Homo sapiens

<400>  891


Met Ala Lys Ala Tyr Asp His Leu Phe Lys Leu Leu Leu Ile Gly Asp 
1               5                   10                  15      


Ser Gly Val Gly Lys Thr Cys Leu Ile Ile Arg Phe Ala Glu Asp Asn 
            20                  25                  30          


Phe Asn Asn Thr Tyr Ile Ser Thr Ile Gly Ile Asp Phe Lys Ile Arg 
        35                  40                  45              


Thr Val Asp Ile Glu Gly Lys Lys Ile Lys Leu Gln Val Trp Asp Thr 
    50                  55                  60                  


Ala Gly Gln Glu Arg Phe Lys Thr Ile Thr Thr Ala Tyr Tyr Arg Gly 
65                  70                  75                  80  


Ala Met Gly Ile Ile Leu Val Tyr Asp Ile Thr Asp Glu Lys Ser Phe 
                85                  90                  95      


Glu Asn Ile Gln Asn Trp Met Lys Ser Ile Lys Glu Asn Ala Ser Ala 
            100                 105                 110         


Gly Val Glu Arg Leu Leu Leu Gly Asn Lys Cys Asp Met Glu Ala Lys 
        115                 120                 125             


Arg Lys Val Gln Lys Glu Gln Ala Asp Lys Leu Ala Arg Glu His Gly 
    130                 135                 140                 


Ile Arg Phe Phe Glu Thr Ser Ala Lys Ser Ser Met Asn Val Asp Glu 
145                 150                 155                 160 


Ala Phe Ser Ser Leu Ala Arg Asp Ile Leu Leu Lys Ser Gly Gly Arg 
                165                 170                 175     


Arg Ser Gly Asn Gly Asn Lys Pro Pro Ser Thr Asp Leu Lys Thr Cys 
            180                 185                 190         


Asp Lys Lys Asn Thr Asn Lys Cys Ser Leu Gly 
        195                 200             

<210>  892
<211>  2258
<212>  DNA
<213>  Homo sapiens

<400>  892
ctctttcccg gagcctgggc ggagagggag gaaaacttct tcctggcctg ggctccgtgc     60

cgctctgttt gccaaccgtc cagtcccgcc taccagtgcc gggcgctccc cacccctccc    120

ccggctcccc cggtgtccgc catggccaaa gcctacgacc acctcttcaa gttgctgctg    180

atcggggact cgggggtggg caagacttgt ctgatcattc gctttgcaga ggacaacttc    240

aacaacactt acatctccac catcggaatt gatttcaaga tccgcactgt ggatatagag    300

gggaagaaga tcaaactaca agtctgggac acggctggcc aagagcggtt caagacaata    360

actactgcct actaccgtgg agccatggta tgaagtgtgg gtctgaacaa aggatgaagg    420

atgaggctac agaatatatt atgaatacaa agggtcaggg gttggggcag gtaaaaatgg    480

gaggggtgca gtgtgggttg cagagggccc aacatggcct agtgtttaga cccatggatg    540

cggggtcact tacagggcag tgggaagcct caatgggaac atggtccaag gtgaattttg    600

tcatctccca gggcattatc ctagtatacg acatcacgga tgagaaatct ttcgagaata    660

ttcagaactg gatgaaaagc atcaaggagg tgaggaccct ccaaaagaga tggggaaact    720

ggttagaacc tggagaatga aggggtccat caggataggc aagacctaac tttttttttt    780

ttgagatgaa gttttgctct tgttgcccgg gctggagtgc aatggcagga tctcggctca    840

ctgcaacctc tgcctcccag gttcaaacga ttttcctgcc tcagcctccc aagtagctgg    900

gattacaggc atgcaccacc atgctcggct aattttgcat ttttagtaga gacgggtttt    960

ctccatgttg gtcaggctga tcttgaactc ctgcatcagg tgatccaccc gccttggcct   1020

cccaaagtgc tgggattaca ggcgtgagcc accgctccca gccggcagga cctaactttt   1080

acttgtcttt tgcccccaga atgcctcggc tggggtggag cgcctcttgc tggggaacaa   1140

atgtgacatg gaggccaaga ggaaggtgca gaaggagcag gccgataagg tgagggccag   1200

gctgagcaat gttctagaac tgggctggga gggccaagat aggttgcatt gcagaggact   1260

tggctgctgt ccttaattca attctcttcc cacttcaccc cttatagttg gctcgagagc   1320

atggaatccg atttttcgaa actagtgcta aatccagtat gaatgtggat gaggtgagat   1380

ccacaccccc atccccgacc aagagaggaa gtattagaag gtagattctc ctccctccaa   1440

actgactctg ttccccactt taggctttta gttccctggc ccgggacatc ttgctcaagt   1500

caggaggccg gagatcagta agttggtttt gctggactag gtacaactct ggggtgtgtg   1560

tgtgtgtatg tatgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgttggtg ttgataaaaa   1620

cggggagcaa tgctaagatt tctcatgagg gtggatttac tttaaacagt ttataccctc   1680

ctaccctaac catccattca caccatgaca cctgtgccct tctccctcta gggaaacggc   1740

aacaagcctc ccagtactga cctgaaaact tgtgacaaga agaacaccaa caagtgctcc   1800

ctgggctgag gaccctttct tgcctcccca ccccggaagc tgaacctgag ggagacaacg   1860

gcagagggag tgagcagggg agaaatagca gaggggcttg gagggtcaca taggtagatg   1920

gtaaagagaa tgaggagaaa aaggagaaaa gggaaaagca gaaaggaaaa aaaggaagag   1980

agaggaaggg agaagggaga ggaatgaatt gaggaagtga aagaaggcaa ggaggtagga   2040

agagagggag gaggaaagga aggagagatg cctcaggctt cagaccttac ctgggttttc   2100

agggcaaaca taaatgtaaa tacactgatt tattctgtta ctagatcagg ttttagggtc   2160

ctgcaaaagg ctagctcggc actacactag ggaatttgct cctgttctgt cacttgtcat   2220

ggtctttctt ggtattaaag gccaccattt gcacaaat                           2258


<210>  893
<211>  83
<212>  PRT
<213>  Homo sapiens

<400>  893


Met Ala Lys Ala Tyr Asp His Leu Phe Lys Leu Leu Leu Ile Gly Asp 
1               5                   10                  15      


Ser Gly Val Gly Lys Thr Cys Leu Ile Ile Arg Phe Ala Glu Asp Asn 
            20                  25                  30          


Phe Asn Asn Thr Tyr Ile Ser Thr Ile Gly Ile Asp Phe Lys Ile Arg 
        35                  40                  45              


Thr Val Asp Ile Glu Gly Lys Lys Ile Lys Leu Gln Val Trp Asp Thr 
    50                  55                  60                  


Ala Gly Gln Glu Arg Phe Lys Thr Ile Thr Thr Ala Tyr Tyr Arg Gly 
65                  70                  75                  80  


Ala Met Val 
            

<210>  894
<211>  641
<212>  DNA
<213>  Homo sapiens

<400>  894
cctttccggc ggtgacgacc tacgcacacg agaacatgcc tgtgagtgct ttggtccagg     60

tttcggcgga gatctcgctg ttctgtccga actctcccct cacgctgatt tcggatcgta    120

gagggtcctc atttaccctc tgcacttctt aggacattaa ctccagggac cgcagcggcc    180

cacgggccac ccgcatagac gggagcggag aggagataag atggcggccc agctgcgcag    240

acaccagggg cggcgagggg cgagctctcc ccggtgtgtg acagtggggg ctattttcga    300

ccatcccatt ttcgctgttg gtttctaaat ctctgcattt ctgtccctct tagctcgcaa    360

aggatctcct tcatccctct ccagaagagg agaagaggaa acacaagaag aaacgcctgg    420

tgcagagccc caattcctac ttcatggatg tgaaatgccc aggatgctat aaaatcacca    480

cggtctttag ccatgcacaa acggtagttt tgtgtgttgg ctgctccact gtcctctgcc    540

agcctacagg aggaaaagca aggcttacag aaggatgttc cttcaggagg aagcagcact    600

aaaagcactc tgagtcaaga tgagtgggaa accatctcaa t                        641


<210>  895
<211>  52
<212>  PRT
<213>  Homo sapiens

<400>  895


Met Asp Val Lys Cys Pro Gly Cys Tyr Lys Ile Thr Thr Val Phe Ser 
1               5                   10                  15      


His Ala Gln Thr Val Val Leu Cys Val Gly Cys Ser Thr Val Leu Cys 
            20                  25                  30          


Gln Pro Thr Gly Gly Lys Ala Arg Leu Thr Glu Gly Cys Ser Phe Arg 
        35                  40                  45              


Arg Lys Gln His 
    50          

<210>  896
<211>  581
<212>  DNA
<213>  Homo sapiens

<400>  896
cctttccggc ggtgacgacc tacgcacacg agaacatgcc tgtgagtgct ttggtccagg     60

tttcggcgga gatctcgctg ttctgtccga actctcccct cacgctgatt tcggatcgta    120

gagggtcctc atttaccctc tgcacttctt aggacattaa ctccagggac cgcagcggcc    180

cacgggccac ccgcatagac gggagcggag aggagataag atggcggccc agctgcgcag    240

acaccagggg cggcgagggg cgagctctcc ccgctcgcaa aggatctcct tcatccctct    300

ccagaagagg agaagaggaa acacaagaag aaacgcctgg tgcagagccc caattcctac    360

ttcatggatg tgaaatgccc aggatgctat aaaatcacca cggtctttag ccatgcacaa    420

acggtagttt tgtgtgttgg ctgctccact gtcctctgcc agcctacagg aggaaaagca    480

aggcttacag aaggatgttc cttcaggagg aagcagcact aaaagcactc tgagtcaaga    540

tgagtgggaa accatctcaa taaacacatt ttggataaat c                        581


<210>  897
<211>  52
<212>  PRT
<213>  Homo sapiens

<400>  897


Met Asp Val Lys Cys Pro Gly Cys Tyr Lys Ile Thr Thr Val Phe Ser 
1               5                   10                  15      


His Ala Gln Thr Val Val Leu Cys Val Gly Cys Ser Thr Val Leu Cys 
            20                  25                  30          


Gln Pro Thr Gly Gly Lys Ala Arg Leu Thr Glu Gly Cys Ser Phe Arg 
        35                  40                  45              


Arg Lys Gln His 
    50          

<210>  898
<211>  5889
<212>  DNA
<213>  Homo sapiens

<400>  898
acgcctgtgg attggctgat ggagctgtga gccggctgta gttgagcggg aacccgagac     60

ctggcagtcg ccatgactgg ctgtccggcg tcatcaagac gccgaggctt cgggctcttt    120

ttcttcttgc gtctacaccg cctcctgttg ttgtttctgg ttttgcgtgg gaccctggcc    180

aacaaactta acgtgccaca ggtgttgcta cccttcggcc gagagccagg ccgggtgcct    240

ttcctgctgg aggcccagcg gggctgctac acttggcatt ccacccatca tgatgcagtt    300

actgttgagc ctttatatga aaatggcacc ttgtgttccc aaaaagctgt actcattgct    360

gaatctacgc aaccgatacg cctcagcagt attattcttg ctcgagaaat agtgactgac    420

catgagctac gctgtgatgt taaggttgat gtgataaaca gcattgaaat tgtatctcgg    480

gcccgggaac tttatgtaga tgattcgcca ctggaactga tggtgagggc attggatgct    540

gaaggaaata cttttagtag tttggcaggg atgatgtttg agtggagcat tgcccaggac    600

aacgagtcag caagagaaga actgtctagc aaaattagga ttcttaaata ctccgaagca    660

gaatatgctc ccccaatata tatagctgag atggaaaaag aggagaaaca aggagatgtg    720

attttagtgt ctgggattag aactggtgct gctgttgtaa aagttcgaat tcatgaacca    780

ttctataaga aagtggcagc agccttaata cgtctgcttg ttttggagaa tatatttctt    840

ataccatccc atgatattta tctcttagta ggaacatata ttaaatacca agttgcaaaa    900

atggttcaag ggagagtgac agaggtgaaa tttcccctgg aacattatat actggaattg    960

caagaccata gagttgcact taacgggtct cattctgaga aagtggctat actggatgac   1020

aaaacagcca tggtgactgc ctcacaactg ggccagacta atcttgtctt tgtccataaa   1080

aatgttcata tgcgatctgt gtctggactc ccaaattgca ccatatatgt tgtagagcct   1140

ggatttttag gtttcactgt ccaacctgga aaccgatgga gtctagaggt gggacaggta   1200

tatgtcatta cagtagacgt ctttgataaa agcagcacaa aggtctatat ttcagataat   1260

ctcaggatta catacgactt tcctaaggag tactttgaag agcaactaac taccgtgaat   1320

ggatcttacc atatagtaaa agccctgaaa gatggtgttg tggtaataaa tgcatccctg   1380

acctccatca tttaccagaa taaagatatt cagcctataa aatttctaat caaacaccaa   1440

caagaagtga agatttattt tcccatcatg cttacaccca aatttctggc atttcctcat   1500

catcctatgg gaatgttata tcgttataaa gtacaggtag agggtggcag tggcaacttt   1560

acctggactt cttctaatga aacagtggtc atagtaacca cgaaaggagt ggtgactgca   1620

ggtcaggtca gggggaatag tactgttttg gcccgagatg tacaaaatcc ctttcgatat   1680

ggagaaatta agatacatgt cctgaaactg aacaaaatgg aactgttacc atttcatgct   1740

gatgtggaga ttggccagat tatagaaata cccattgcaa tgtatcacat aaataaagag   1800

accaaagaag ccatggcatt cacagactgc tctcatttat ccttggatct gaacatggat   1860

aaacaaggag tctttactct tctcaaagaa ggtattcaaa gacctggacc aatgcattgt   1920

tccagtacac atatcgcagc taaatctctt ggccatactc tggtaacagt aagtgtgaat   1980

gaatgtgaca agtacttgga gagcagtgct acatttgctg cttatgaacc cctaaaggct   2040

ttaaatcctg tggaagtggc attggtgaca tggcagtctg tgaaggaaat ggtatttgaa   2100

gggggtcctc gtccatggat cttggagccc tcccgatttt ttttggaatt gaatgcggag   2160

aagacagaga agattggaat agcacaagtg tggctgccat ctaagagaaa acagaaccag   2220

tacatctacc ggatccaatg cctggattta ggggaacaag ttctcacatt ccgaattgga   2280

aatcatccag gtgtcctgaa ccctagtcca gctgtagagg ttttgcaggt tcgcttcatt   2340

tgtgcccacc ctgccagtat gtcagtaact ccagtataca aggtgccagc tggtgcccag   2400

ccatgtcctc tgccacagca caacaaatgg ctgattcctg tatcaagact gagggacaca   2460

gtcctggaac tagcagtgtt tgatcaacat aggagaaagt ttgataattt cagttcacta   2520

atgctagaat ggaaatcctc caatgaaaca ctagcccatt tcgaagatta taaatcagtg   2580

gaaatggtag caaaagatga tggcagtggg cagacccggt tacatggtca tcagatcctt   2640

aaagtacatc agataaaagg gactgtactg attggagtca attttgtggg ctattcagag   2700

aagaaaagcc caaaagaaat ttccaacttg cccagatctg tagatgtgga actgctcctg   2760

gtagatgatg taactgtagt gcctgagaat gccaccatct ataaccaccc tgatgtaaag   2820

gaaacattta gccttgtgga aggatctggt tattttttag tcaacagcag tgagcagggt   2880

gttgtcacca tcacttacat ggaagcagaa agctctgttg agttagttcc attacatcct   2940

ggatttttta ccttggaggt ctatgatctt tgtttggctt tcttgggtcc agcaacagcc   3000

cacctcaggg tgtcagacat acaagagctg gagcttgatc tgattgataa ggttgaaata   3060

gacaaaactg tgttagtgac tgtgagggtt cttggctctt ccaaacgccc attccaaaat   3120

aaatacttca gaaacatgga actcaaactg cagttggctt ctgccattgt caccctgaca   3180

ccaatggagc aacaggacga atactctgaa aattatattc ttcgagctac cactattggg   3240

caaaccacac ttgtggctat tgccaaggac aagatgggaa gaaaatacac atcaactcct   3300

cggcacattg aagtgtttcc tccattcaga cttcttccag agaaaatgac actgattcca   3360

atgaatatga tgcaggtaat gtctgaaggt ggcccccagc cccaatccat cgttcacttc   3420

tccatcagta atcagaccgt ggctgttgtt aataggaggg ggcaagttac agggaagatt   3480

gttggcacag ctgtggttca tggcaccatc cagacagtaa atgaagatac tggcaaagtc   3540

attgtgtttt ctcaggatga agtacagatt gaagttgttc agctaagggc tgttaggatc   3600

cttgcagctg caactcggct catcacagct accaagatgc cagtttatgt catgggagta   3660

accagtaccc agaccccttt ctccttcagc aatgctaatc ctgggctcac attccactgg   3720

tctatgagca aaagggatgt attggatcta gtgcccaggc attcagaggt ttttctacag   3780

ctcccagtag agcataactt tgccatggtt gtccatacaa aagcagcagg caggaccagt   3840

atcaaggtca ctgttcactg catgaacagt tcctctgggc agtttgaggg gaatttgttg   3900

gaactctctg atgaagtaca gatcctggtg tttgaaaaac tccaactctt ctatccagag   3960

tgccaaccag agcagattct gatgcctata aattctcagc tcaaactcca taccaacagg   4020

gaaggagctg ccttcgtgag ttctcgtgtt ctcaagtgtt tccctaattc atccgtcatt   4080

gaggaggatg gtgaagggct cctgaaagct ggttccattg caggtactgc tgtattggaa   4140

gtcacttcta tagaaccttt tggagtcaac caaacaacca taactggggt ccaggtagca   4200

ccggtgacat acctgcgagt gagcagccaa cccaagctat acacagccca aggaaggacc   4260

ctgtcagcat ttcccttggg catgtctctt accttcactg ttcagtttta taatagtatc   4320

ggagagaaat tccacacaca caatacccag ctttatctgg ctctgaacag agatgacttg   4380

ctgcatattg gaccagggaa taagaactat acttacatgg cccaggctgt gaacagaggg   4440

ctgacacttg tggggctttg ggaccggaga catccaggca tggcagatta tattcctgtt   4500

gctgtagagc atgccattga gccagacacc aagcttacct ttgttggaga tatcatctgc   4560

ttcagtactc accttgtcag ccagcatggt gaacctggga tatggatgat ttctgccaac   4620

aatattctac agacagacat tgtcactgga gtaggagtgg ccaggagtcc ggggactgca   4680

atgatttttc atgacatccc aggagtagtg aaaacatatc gagaggtggt ggtcaatgca   4740

tcatcaagat taatgctcag ttatgacctc aagacttatc tcaccaatac cctcaattca   4800

actgtattca agctcttcat caccactggc agaaatggtg tcaatcttaa aggattctgt   4860

accccaaacc aggccttggc cattacaaaa gtacttcttc cagcgaccct catgctgtgc   4920

catgtacagt tcagtaatac tttgctagac attccagcaa gtaaagtctt tcaggtccat   4980

tcagatttca gtatggagaa aggggtttat gtctgcataa tcaaggttcg accgcagtca   5040

gaggagctgc tacaggccct cagtgtggct gacacctcag tctatgggtg ggctacactg   5100

gtcagtgaac gtagcaagaa tggaatgcaa cgaatcctca ttcctttcat cccagccttt   5160

tatattaacc agtcagaatt ggttcttagc cacaaacaag atatcgggga gataagagta   5220

ctgggagtgg acagagttct taggaagcta gaggtcatct ccagctcccc agttctagtg   5280

gtcgctggcc atagccactc tcccctcact cctggcctgg ccatttactc tgtaagagtg   5340

gtcaacttca cttccttcca gcaaatggca tcacctgttt tcatcaatat ttcctgtgta   5400

ctcaccagtc aaagtgaggc agtggtagtg agggctatga aagataagtt gggtgcagat   5460

cactgtgaag attccgccat cctcaagcgg ttcactggct cttaccagat cctgctcttg   5520

accctctttg cagtgctggc atcaacagct tccatcttcc tagcatacaa tgccttccta   5580

aacaagatac aaacagttcc agttgtgtat gtaccaactc taggaacacc acagccaggt   5640

ttttttaact ccacaagttc tccccctcac ttcatgagtc tacaacctcc attggcccaa   5700

agtcggctgc aacattggtt atggagtata aggcactaac ctctgcttgg acaagtttct   5760

cttaactgca ggggaatgaa gatttctagt cctcgacaag aagcctaaca gcaacttcta   5820

cattaagttt ccagataagg cttctgagaa ctataaataa agcatcctaa gctgtttctt   5880

aaaactggt                                                           5889


<210>  899
<211>  1888
<212>  PRT
<213>  Homo sapiens

<400>  899


Met Thr Gly Cys Pro Ala Ser Ser Arg Arg Arg Gly Phe Gly Leu Phe 
1               5                   10                  15      


Phe Phe Leu Arg Leu His Arg Leu Leu Leu Leu Phe Leu Val Leu Arg 
            20                  25                  30          


Gly Thr Leu Ala Asn Lys Leu Asn Val Pro Gln Val Leu Leu Pro Phe 
        35                  40                  45              


Gly Arg Glu Pro Gly Arg Val Pro Phe Leu Leu Glu Ala Gln Arg Gly 
    50                  55                  60                  


Cys Tyr Thr Trp His Ser Thr His His Asp Ala Val Thr Val Glu Pro 
65                  70                  75                  80  


Leu Tyr Glu Asn Gly Thr Leu Cys Ser Gln Lys Ala Val Leu Ile Ala 
                85                  90                  95      


Glu Ser Thr Gln Pro Ile Arg Leu Ser Ser Ile Ile Leu Ala Arg Glu 
            100                 105                 110         


Ile Val Thr Asp His Glu Leu Arg Cys Asp Val Lys Val Asp Val Ile 
        115                 120                 125             


Asn Ser Ile Glu Ile Val Ser Arg Ala Arg Glu Leu Tyr Val Asp Asp 
    130                 135                 140                 


Ser Pro Leu Glu Leu Met Val Arg Ala Leu Asp Ala Glu Gly Asn Thr 
145                 150                 155                 160 


Phe Ser Ser Leu Ala Gly Met Met Phe Glu Trp Ser Ile Ala Gln Asp 
                165                 170                 175     


Asn Glu Ser Ala Arg Glu Glu Leu Ser Ser Lys Ile Arg Ile Leu Lys 
            180                 185                 190         


Tyr Ser Glu Ala Glu Tyr Ala Pro Pro Ile Tyr Ile Ala Glu Met Glu 
        195                 200                 205             


Lys Glu Glu Lys Gln Gly Asp Val Ile Leu Val Ser Gly Ile Arg Thr 
    210                 215                 220                 


Gly Ala Ala Val Val Lys Val Arg Ile His Glu Pro Phe Tyr Lys Lys 
225                 230                 235                 240 


Val Ala Ala Ala Leu Ile Arg Leu Leu Val Leu Glu Asn Ile Phe Leu 
                245                 250                 255     


Ile Pro Ser His Asp Ile Tyr Leu Leu Val Gly Thr Tyr Ile Lys Tyr 
            260                 265                 270         


Gln Val Ala Lys Met Val Gln Gly Arg Val Thr Glu Val Lys Phe Pro 
        275                 280                 285             


Leu Glu His Tyr Ile Leu Glu Leu Gln Asp His Arg Val Ala Leu Asn 
    290                 295                 300                 


Gly Ser His Ser Glu Lys Val Ala Ile Leu Asp Asp Lys Thr Ala Met 
305                 310                 315                 320 


Val Thr Ala Ser Gln Leu Gly Gln Thr Asn Leu Val Phe Val His Lys 
                325                 330                 335     


Asn Val His Met Arg Ser Val Ser Gly Leu Pro Asn Cys Thr Ile Tyr 
            340                 345                 350         


Val Val Glu Pro Gly Phe Leu Gly Phe Thr Val Gln Pro Gly Asn Arg 
        355                 360                 365             


Trp Ser Leu Glu Val Gly Gln Val Tyr Val Ile Thr Val Asp Val Phe 
    370                 375                 380                 


Asp Lys Ser Ser Thr Lys Val Tyr Ile Ser Asp Asn Leu Arg Ile Thr 
385                 390                 395                 400 


Tyr Asp Phe Pro Lys Glu Tyr Phe Glu Glu Gln Leu Thr Thr Val Asn 
                405                 410                 415     


Gly Ser Tyr His Ile Val Lys Ala Leu Lys Asp Gly Val Val Val Ile 
            420                 425                 430         


Asn Ala Ser Leu Thr Ser Ile Ile Tyr Gln Asn Lys Asp Ile Gln Pro 
        435                 440                 445             


Ile Lys Phe Leu Ile Lys His Gln Gln Glu Val Lys Ile Tyr Phe Pro 
    450                 455                 460                 


Ile Met Leu Thr Pro Lys Phe Leu Ala Phe Pro His His Pro Met Gly 
465                 470                 475                 480 


Met Leu Tyr Arg Tyr Lys Val Gln Val Glu Gly Gly Ser Gly Asn Phe 
                485                 490                 495     


Thr Trp Thr Ser Ser Asn Glu Thr Val Val Ile Val Thr Thr Lys Gly 
            500                 505                 510         


Val Val Thr Ala Gly Gln Val Arg Gly Asn Ser Thr Val Leu Ala Arg 
        515                 520                 525             


Asp Val Gln Asn Pro Phe Arg Tyr Gly Glu Ile Lys Ile His Val Leu 
    530                 535                 540                 


Lys Leu Asn Lys Met Glu Leu Leu Pro Phe His Ala Asp Val Glu Ile 
545                 550                 555                 560 


Gly Gln Ile Ile Glu Ile Pro Ile Ala Met Tyr His Ile Asn Lys Glu 
                565                 570                 575     


Thr Lys Glu Ala Met Ala Phe Thr Asp Cys Ser His Leu Ser Leu Asp 
            580                 585                 590         


Leu Asn Met Asp Lys Gln Gly Val Phe Thr Leu Leu Lys Glu Gly Ile 
        595                 600                 605             


Gln Arg Pro Gly Pro Met His Cys Ser Ser Thr His Ile Ala Ala Lys 
    610                 615                 620                 


Ser Leu Gly His Thr Leu Val Thr Val Ser Val Asn Glu Cys Asp Lys 
625                 630                 635                 640 


Tyr Leu Glu Ser Ser Ala Thr Phe Ala Ala Tyr Glu Pro Leu Lys Ala 
                645                 650                 655     


Leu Asn Pro Val Glu Val Ala Leu Val Thr Trp Gln Ser Val Lys Glu 
            660                 665                 670         


Met Val Phe Glu Gly Gly Pro Arg Pro Trp Ile Leu Glu Pro Ser Arg 
        675                 680                 685             


Phe Phe Leu Glu Leu Asn Ala Glu Lys Thr Glu Lys Ile Gly Ile Ala 
    690                 695                 700                 


Gln Val Trp Leu Pro Ser Lys Arg Lys Gln Asn Gln Tyr Ile Tyr Arg 
705                 710                 715                 720 


Ile Gln Cys Leu Asp Leu Gly Glu Gln Val Leu Thr Phe Arg Ile Gly 
                725                 730                 735     


Asn His Pro Gly Val Leu Asn Pro Ser Pro Ala Val Glu Val Leu Gln 
            740                 745                 750         


Val Arg Phe Ile Cys Ala His Pro Ala Ser Met Ser Val Thr Pro Val 
        755                 760                 765             


Tyr Lys Val Pro Ala Gly Ala Gln Pro Cys Pro Leu Pro Gln His Asn 
    770                 775                 780                 


Lys Trp Leu Ile Pro Val Ser Arg Leu Arg Asp Thr Val Leu Glu Leu 
785                 790                 795                 800 


Ala Val Phe Asp Gln His Arg Arg Lys Phe Asp Asn Phe Ser Ser Leu 
                805                 810                 815     


Met Leu Glu Trp Lys Ser Ser Asn Glu Thr Leu Ala His Phe Glu Asp 
            820                 825                 830         


Tyr Lys Ser Val Glu Met Val Ala Lys Asp Asp Gly Ser Gly Gln Thr 
        835                 840                 845             


Arg Leu His Gly His Gln Ile Leu Lys Val His Gln Ile Lys Gly Thr 
    850                 855                 860                 


Val Leu Ile Gly Val Asn Phe Val Gly Tyr Ser Glu Lys Lys Ser Pro 
865                 870                 875                 880 


Lys Glu Ile Ser Asn Leu Pro Arg Ser Val Asp Val Glu Leu Leu Leu 
                885                 890                 895     


Val Asp Asp Val Thr Val Val Pro Glu Asn Ala Thr Ile Tyr Asn His 
            900                 905                 910         


Pro Asp Val Lys Glu Thr Phe Ser Leu Val Glu Gly Ser Gly Tyr Phe 
        915                 920                 925             


Leu Val Asn Ser Ser Glu Gln Gly Val Val Thr Ile Thr Tyr Met Glu 
    930                 935                 940                 


Ala Glu Ser Ser Val Glu Leu Val Pro Leu His Pro Gly Phe Phe Thr 
945                 950                 955                 960 


Leu Glu Val Tyr Asp Leu Cys Leu Ala Phe Leu Gly Pro Ala Thr Ala 
                965                 970                 975     


His Leu Arg Val Ser Asp Ile Gln Glu Leu Glu Leu Asp Leu Ile Asp 
            980                 985                 990         


Lys Val Glu Ile Asp Lys Thr Val  Leu Val Thr Val Arg  Val Leu Gly 
        995                 1000                 1005             


Ser Ser  Lys Arg Pro Phe Gln  Asn Lys Tyr Phe Arg  Asn Met Glu 
    1010                 1015                 1020             


Leu Lys  Leu Gln Leu Ala Ser  Ala Ile Val Thr Leu  Thr Pro Met 
    1025                 1030                 1035             


Glu Gln  Gln Asp Glu Tyr Ser  Glu Asn Tyr Ile Leu  Arg Ala Thr 
    1040                 1045                 1050             


Thr Ile  Gly Gln Thr Thr Leu  Val Ala Ile Ala Lys  Asp Lys Met 
    1055                 1060                 1065             


Gly Arg  Lys Tyr Thr Ser Thr  Pro Arg His Ile Glu  Val Phe Pro 
    1070                 1075                 1080             


Pro Phe  Arg Leu Leu Pro Glu  Lys Met Thr Leu Ile  Pro Met Asn 
    1085                 1090                 1095             


Met Met  Gln Val Met Ser Glu  Gly Gly Pro Gln Pro  Gln Ser Ile 
    1100                 1105                 1110             


Val His  Phe Ser Ile Ser Asn  Gln Thr Val Ala Val  Val Asn Arg 
    1115                 1120                 1125             


Arg Gly  Gln Val Thr Gly Lys  Ile Val Gly Thr Ala  Val Val His 
    1130                 1135                 1140             


Gly Thr  Ile Gln Thr Val Asn  Glu Asp Thr Gly Lys  Val Ile Val 
    1145                 1150                 1155             


Phe Ser  Gln Asp Glu Val Gln  Ile Glu Val Val Gln  Leu Arg Ala 
    1160                 1165                 1170             


Val Arg  Ile Leu Ala Ala Ala  Thr Arg Leu Ile Thr  Ala Thr Lys 
    1175                 1180                 1185             


Met Pro  Val Tyr Val Met Gly  Val Thr Ser Thr Gln  Thr Pro Phe 
    1190                 1195                 1200             


Ser Phe  Ser Asn Ala Asn Pro  Gly Leu Thr Phe His  Trp Ser Met 
    1205                 1210                 1215             


Ser Lys  Arg Asp Val Leu Asp  Leu Val Pro Arg His  Ser Glu Val 
    1220                 1225                 1230             


Phe Leu  Gln Leu Pro Val Glu  His Asn Phe Ala Met  Val Val His 
    1235                 1240                 1245             


Thr Lys  Ala Ala Gly Arg Thr  Ser Ile Lys Val Thr  Val His Cys 
    1250                 1255                 1260             


Met Asn  Ser Ser Ser Gly Gln  Phe Glu Gly Asn Leu  Leu Glu Leu 
    1265                 1270                 1275             


Ser Asp  Glu Val Gln Ile Leu  Val Phe Glu Lys Leu  Gln Leu Phe 
    1280                 1285                 1290             


Tyr Pro  Glu Cys Gln Pro Glu  Gln Ile Leu Met Pro  Ile Asn Ser 
    1295                 1300                 1305             


Gln Leu  Lys Leu His Thr Asn  Arg Glu Gly Ala Ala  Phe Val Ser 
    1310                 1315                 1320             


Ser Arg  Val Leu Lys Cys Phe  Pro Asn Ser Ser Val  Ile Glu Glu 
    1325                 1330                 1335             


Asp Gly  Glu Gly Leu Leu Lys  Ala Gly Ser Ile Ala  Gly Thr Ala 
    1340                 1345                 1350             


Val Leu  Glu Val Thr Ser Ile  Glu Pro Phe Gly Val  Asn Gln Thr 
    1355                 1360                 1365             


Thr Ile  Thr Gly Val Gln Val  Ala Pro Val Thr Tyr  Leu Arg Val 
    1370                 1375                 1380             


Ser Ser  Gln Pro Lys Leu Tyr  Thr Ala Gln Gly Arg  Thr Leu Ser 
    1385                 1390                 1395             


Ala Phe  Pro Leu Gly Met Ser  Leu Thr Phe Thr Val  Gln Phe Tyr 
    1400                 1405                 1410             


Asn Ser  Ile Gly Glu Lys Phe  His Thr His Asn Thr  Gln Leu Tyr 
    1415                 1420                 1425             


Leu Ala  Leu Asn Arg Asp Asp  Leu Leu His Ile Gly  Pro Gly Asn 
    1430                 1435                 1440             


Lys Asn  Tyr Thr Tyr Met Ala  Gln Ala Val Asn Arg  Gly Leu Thr 
    1445                 1450                 1455             


Leu Val  Gly Leu Trp Asp Arg  Arg His Pro Gly Met  Ala Asp Tyr 
    1460                 1465                 1470             


Ile Pro  Val Ala Val Glu His  Ala Ile Glu Pro Asp  Thr Lys Leu 
    1475                 1480                 1485             


Thr Phe  Val Gly Asp Ile Ile  Cys Phe Ser Thr His  Leu Val Ser 
    1490                 1495                 1500             


Gln His  Gly Glu Pro Gly Ile  Trp Met Ile Ser Ala  Asn Asn Ile 
    1505                 1510                 1515             


Leu Gln  Thr Asp Ile Val Thr  Gly Val Gly Val Ala  Arg Ser Pro 
    1520                 1525                 1530             


Gly Thr  Ala Met Ile Phe His  Asp Ile Pro Gly Val  Val Lys Thr 
    1535                 1540                 1545             


Tyr Arg  Glu Val Val Val Asn  Ala Ser Ser Arg Leu  Met Leu Ser 
    1550                 1555                 1560             


Tyr Asp  Leu Lys Thr Tyr Leu  Thr Asn Thr Leu Asn  Ser Thr Val 
    1565                 1570                 1575             


Phe Lys  Leu Phe Ile Thr Thr  Gly Arg Asn Gly Val  Asn Leu Lys 
    1580                 1585                 1590             


Gly Phe  Cys Thr Pro Asn Gln  Ala Leu Ala Ile Thr  Lys Val Leu 
    1595                 1600                 1605             


Leu Pro  Ala Thr Leu Met Leu  Cys His Val Gln Phe  Ser Asn Thr 
    1610                 1615                 1620             


Leu Leu  Asp Ile Pro Ala Ser  Lys Val Phe Gln Val  His Ser Asp 
    1625                 1630                 1635             


Phe Ser  Met Glu Lys Gly Val  Tyr Val Cys Ile Ile  Lys Val Arg 
    1640                 1645                 1650             


Pro Gln  Ser Glu Glu Leu Leu  Gln Ala Leu Ser Val  Ala Asp Thr 
    1655                 1660                 1665             


Ser Val  Tyr Gly Trp Ala Thr  Leu Val Ser Glu Arg  Ser Lys Asn 
    1670                 1675                 1680             


Gly Met  Gln Arg Ile Leu Ile  Pro Phe Ile Pro Ala  Phe Tyr Ile 
    1685                 1690                 1695             


Asn Gln  Ser Glu Leu Val Leu  Ser His Lys Gln Asp  Ile Gly Glu 
    1700                 1705                 1710             


Ile Arg  Val Leu Gly Val Asp  Arg Val Leu Arg Lys  Leu Glu Val 
    1715                 1720                 1725             


Ile Ser  Ser Ser Pro Val Leu  Val Val Ala Gly His  Ser His Ser 
    1730                 1735                 1740             


Pro Leu  Thr Pro Gly Leu Ala  Ile Tyr Ser Val Arg  Val Val Asn 
    1745                 1750                 1755             


Phe Thr  Ser Phe Gln Gln Met  Ala Ser Pro Val Phe  Ile Asn Ile 
    1760                 1765                 1770             


Ser Cys  Val Leu Thr Ser Gln  Ser Glu Ala Val Val  Val Arg Ala 
    1775                 1780                 1785             


Met Lys  Asp Lys Leu Gly Ala  Asp His Cys Glu Asp  Ser Ala Ile 
    1790                 1795                 1800             


Leu Lys  Arg Phe Thr Gly Ser  Tyr Gln Ile Leu Leu  Leu Thr Leu 
    1805                 1810                 1815             


Phe Ala  Val Leu Ala Ser Thr  Ala Ser Ile Phe Leu  Ala Tyr Asn 
    1820                 1825                 1830             


Ala Phe  Leu Asn Lys Ile Gln  Thr Val Pro Val Val  Tyr Val Pro 
    1835                 1840                 1845             


Thr Leu  Gly Thr Pro Gln Pro  Gly Phe Phe Asn Ser  Thr Ser Ser 
    1850                 1855                 1860             


Pro Pro  His Phe Met Ser Leu  Gln Pro Pro Leu Ala  Gln Ser Arg 
    1865                 1870                 1875             


Leu Gln  His Trp Leu Trp Ser  Ile Arg His 
    1880                 1885             

<210>  900
<211>  2168
<212>  DNA
<213>  Homo sapiens

<400>  900
tgccaaggac aagatgggaa gaaaatacac atcaactcct cggcacattg aagtgtttcc     60

tccattcaga cttcttccag agaaaatgac actgattcca atgaatatga tgcaggtaat    120

gtctgaaggt ggcccccagc cccaatccat cgttcacttc tccatcagta atcagaccgt    180

ggctgttgtt aataggaggg ggcaagttac agggaagatt gttggcacag ctgtggttca    240

tggcaccatc cagacagtaa atgaagatac tggcaaagtc attgtgtttt ctcaggatga    300

agtacagatt gaagttgttc agctaagggc tgttaggatc cttgcagctg caactcggct    360

catcacagct accaagatgc cagtttatgt catgggagta accagtaccc agaccccttt    420

ctccttcagc aatgctaatc ctgggctcac attccactgg tctatgagca aaagggatgt    480

attggatcta gtgcccaggc attcagaggt ttttctacag ctcccagtag agcataactt    540

tgccatggtt gtccatacaa aagcagcagg caggaccagt atcaaggtca ctgttcactg    600

catgaacagt tcctctgggc agtttgaggg gaatttgttg gaactctctg atgaagtaca    660

gatcctggtg tttgaaaaac tccaactctt ctatccagag tgccaaccag agcagattct    720

gatgcctata aattctcagc tcaaactcca taccaacagg gaaggagctg ccttcgtgag    780

ttctcgtgtt ctcaagtgtt tccctaattc atccgtcatt gaggaggatg gtgaagggct    840

cctgaaagct ggttccattg caggtactgc tgtattggaa gtcacttcta tagaaccttt    900

tggagtcaac caaacaacca taactggggt ccaggtagca ccggtgacat acctgcgagt    960

gagcagccaa cccaagctat acacagccca aggaaggacc ctgtcagcat ttcccttggg   1020

catgtctctt accttcactg ttcagtttta taatagtatc ggagagaaat tccacacaca   1080

caatacccag ctttatctgg ctctgaacag agatgacttg ctgcatattg gaccagggaa   1140

taagaactat acttacatgg cccaggctgt gaacagaggg ctgacacttg tggggctttg   1200

ggaccggaga catccaggca tggcagatta tattcctgtt gctgtagagc atgccattga   1260

gccagacacc aagcttacct ttgttggaga tatcatctgc ttcagtactc accttgtcag   1320

ccagcatggt gaacctggga tatggatgat ttctgccaac aatattctac agacagacat   1380

tgtcactgga gtaggagtgg ccaggagtcc ggggactgca atgatttttc atgacatccc   1440

aggagtagtg aaaacatatc gagaggtggt ggtcaatgca tcatcaagat taatgctcag   1500

ttatgacctc aagacttatc tcaccaatac cctcaattca actgtattca agctcttcat   1560

caccactggc agaaatggtg tcaatcttaa aggattctgt accccaaacc aggccttggc   1620

cattacaaaa gtacttcttc cagcgaccct catgctgtgc catgtacagt tcagtaatac   1680

tttgctagac attccagcaa gtaaagtctt tcaggtccat tcagatttca gtatggagaa   1740

agatcactgt gaagattccg ccatcctcaa gcggttcact ggctcttacc agatcctgct   1800

cttgaccctc tttgcagtgc tggcatcaac agcttccatc ttcctagcat acaatgcctt   1860

cctaaacaag atacaaacag ttccagttgt gtatgtacca actctaggaa caccacagcc   1920

aggttttttt aactccacaa gttctccccc tcacttcatg agtctacaac ctccattggc   1980

ccaaagtcgg ctgcaacatt ggttatggag tataaggcac taacctctgc ttggacaagt   2040

ttctcttaac tgcaggggaa tgaagatttc tagtcctcga caagaagcct aacagcaact   2100

tctacattaa gtttccagat aaggcttctg agaactataa ataaagcatc ctaagctgtt   2160

tcttaaaa                                                            2168


<210>  901
<211>  669
<212>  PRT
<213>  Homo sapiens

<400>  901


Met Gly Arg Lys Tyr Thr Ser Thr Pro Arg His Ile Glu Val Phe Pro 
1               5                   10                  15      


Pro Phe Arg Leu Leu Pro Glu Lys Met Thr Leu Ile Pro Met Asn Met 
            20                  25                  30          


Met Gln Val Met Ser Glu Gly Gly Pro Gln Pro Gln Ser Ile Val His 
        35                  40                  45              


Phe Ser Ile Ser Asn Gln Thr Val Ala Val Val Asn Arg Arg Gly Gln 
    50                  55                  60                  


Val Thr Gly Lys Ile Val Gly Thr Ala Val Val His Gly Thr Ile Gln 
65                  70                  75                  80  


Thr Val Asn Glu Asp Thr Gly Lys Val Ile Val Phe Ser Gln Asp Glu 
                85                  90                  95      


Val Gln Ile Glu Val Val Gln Leu Arg Ala Val Arg Ile Leu Ala Ala 
            100                 105                 110         


Ala Thr Arg Leu Ile Thr Ala Thr Lys Met Pro Val Tyr Val Met Gly 
        115                 120                 125             


Val Thr Ser Thr Gln Thr Pro Phe Ser Phe Ser Asn Ala Asn Pro Gly 
    130                 135                 140                 


Leu Thr Phe His Trp Ser Met Ser Lys Arg Asp Val Leu Asp Leu Val 
145                 150                 155                 160 


Pro Arg His Ser Glu Val Phe Leu Gln Leu Pro Val Glu His Asn Phe 
                165                 170                 175     


Ala Met Val Val His Thr Lys Ala Ala Gly Arg Thr Ser Ile Lys Val 
            180                 185                 190         


Thr Val His Cys Met Asn Ser Ser Ser Gly Gln Phe Glu Gly Asn Leu 
        195                 200                 205             


Leu Glu Leu Ser Asp Glu Val Gln Ile Leu Val Phe Glu Lys Leu Gln 
    210                 215                 220                 


Leu Phe Tyr Pro Glu Cys Gln Pro Glu Gln Ile Leu Met Pro Ile Asn 
225                 230                 235                 240 


Ser Gln Leu Lys Leu His Thr Asn Arg Glu Gly Ala Ala Phe Val Ser 
                245                 250                 255     


Ser Arg Val Leu Lys Cys Phe Pro Asn Ser Ser Val Ile Glu Glu Asp 
            260                 265                 270         


Gly Glu Gly Leu Leu Lys Ala Gly Ser Ile Ala Gly Thr Ala Val Leu 
        275                 280                 285             


Glu Val Thr Ser Ile Glu Pro Phe Gly Val Asn Gln Thr Thr Ile Thr 
    290                 295                 300                 


Gly Val Gln Val Ala Pro Val Thr Tyr Leu Arg Val Ser Ser Gln Pro 
305                 310                 315                 320 


Lys Leu Tyr Thr Ala Gln Gly Arg Thr Leu Ser Ala Phe Pro Leu Gly 
                325                 330                 335     


Met Ser Leu Thr Phe Thr Val Gln Phe Tyr Asn Ser Ile Gly Glu Lys 
            340                 345                 350         


Phe His Thr His Asn Thr Gln Leu Tyr Leu Ala Leu Asn Arg Asp Asp 
        355                 360                 365             


Leu Leu His Ile Gly Pro Gly Asn Lys Asn Tyr Thr Tyr Met Ala Gln 
    370                 375                 380                 


Ala Val Asn Arg Gly Leu Thr Leu Val Gly Leu Trp Asp Arg Arg His 
385                 390                 395                 400 


Pro Gly Met Ala Asp Tyr Ile Pro Val Ala Val Glu His Ala Ile Glu 
                405                 410                 415     


Pro Asp Thr Lys Leu Thr Phe Val Gly Asp Ile Ile Cys Phe Ser Thr 
            420                 425                 430         


His Leu Val Ser Gln His Gly Glu Pro Gly Ile Trp Met Ile Ser Ala 
        435                 440                 445             


Asn Asn Ile Leu Gln Thr Asp Ile Val Thr Gly Val Gly Val Ala Arg 
    450                 455                 460                 


Ser Pro Gly Thr Ala Met Ile Phe His Asp Ile Pro Gly Val Val Lys 
465                 470                 475                 480 


Thr Tyr Arg Glu Val Val Val Asn Ala Ser Ser Arg Leu Met Leu Ser 
                485                 490                 495     


Tyr Asp Leu Lys Thr Tyr Leu Thr Asn Thr Leu Asn Ser Thr Val Phe 
            500                 505                 510         


Lys Leu Phe Ile Thr Thr Gly Arg Asn Gly Val Asn Leu Lys Gly Phe 
        515                 520                 525             


Cys Thr Pro Asn Gln Ala Leu Ala Ile Thr Lys Val Leu Leu Pro Ala 
    530                 535                 540                 


Thr Leu Met Leu Cys His Val Gln Phe Ser Asn Thr Leu Leu Asp Ile 
545                 550                 555                 560 


Pro Ala Ser Lys Val Phe Gln Val His Ser Asp Phe Ser Met Glu Lys 
                565                 570                 575     


Asp His Cys Glu Asp Ser Ala Ile Leu Lys Arg Phe Thr Gly Ser Tyr 
            580                 585                 590         


Gln Ile Leu Leu Leu Thr Leu Phe Ala Val Leu Ala Ser Thr Ala Ser 
        595                 600                 605             


Ile Phe Leu Ala Tyr Asn Ala Phe Leu Asn Lys Ile Gln Thr Val Pro 
    610                 615                 620                 


Val Val Tyr Val Pro Thr Leu Gly Thr Pro Gln Pro Gly Phe Phe Asn 
625                 630                 635                 640 


Ser Thr Ser Ser Pro Pro His Phe Met Ser Leu Gln Pro Pro Leu Ala 
                645                 650                 655     


Gln Ser Arg Leu Gln His Trp Leu Trp Ser Ile Arg His 
            660                 665                 

<210>  902
<211>  547
<212>  DNA
<213>  Homo sapiens

<400>  902
gtagttgagc gggaacccga gacctggcag tcgccatgac tggctgtccg gcgtcatcaa     60

gacgccgagg cttcgggctc tttttcttct tgcgtctaca ccgcctcctg ttgttgtttc    120

tggttttgcg tgggaccctg gccaacaaac ttaacgtgcc acaggtgttg ctacccttcg    180

gccgagagcc aggccgggtg cctttcctgc tggaggccca gcggggctgc tacacttggc    240

attccaccca tcatgatgca gttactgttg agcctttata tgaaaatggc accttgtgtt    300

cccaaaaagc tgtactcatt gctgaatcta cgcaaccgat acgcctcagc agtattattc    360

ttgctcgaga aataggaaat acttttagta gtttggcagg gatgatgttt gagtggagca    420

ttgcccagga caacgagtca gcaagagaag aactgtctag caaaattagg attcttaaat    480

actccgaagc agaatatgct cccccaatat atatagctga gatggaaaaa gaggagaaac    540

aaggaga                                                              547


<210>  903
<211>  169
<212>  PRT
<213>  Homo sapiens

<400>  903


Met Thr Gly Cys Pro Ala Ser Ser Arg Arg Arg Gly Phe Gly Leu Phe 
1               5                   10                  15      


Phe Phe Leu Arg Leu His Arg Leu Leu Leu Leu Phe Leu Val Leu Arg 
            20                  25                  30          


Gly Thr Leu Ala Asn Lys Leu Asn Val Pro Gln Val Leu Leu Pro Phe 
        35                  40                  45              


Gly Arg Glu Pro Gly Arg Val Pro Phe Leu Leu Glu Ala Gln Arg Gly 
    50                  55                  60                  


Cys Tyr Thr Trp His Ser Thr His His Asp Ala Val Thr Val Glu Pro 
65                  70                  75                  80  


Leu Tyr Glu Asn Gly Thr Leu Cys Ser Gln Lys Ala Val Leu Ile Ala 
                85                  90                  95      


Glu Ser Thr Gln Pro Ile Arg Leu Ser Ser Ile Ile Leu Ala Arg Glu 
            100                 105                 110         


Ile Gly Asn Thr Phe Ser Ser Leu Ala Gly Met Met Phe Glu Trp Ser 
        115                 120                 125             


Ile Ala Gln Asp Asn Glu Ser Ala Arg Glu Glu Leu Ser Ser Lys Ile 
    130                 135                 140                 


Arg Ile Leu Lys Tyr Ser Glu Ala Glu Tyr Ala Pro Pro Ile Tyr Ile 
145                 150                 155                 160 


Ala Glu Met Glu Lys Glu Glu Lys Gln 
                165                 

<210>  904
<211>  548
<212>  DNA
<213>  Homo sapiens

<400>  904
tgatggagct gtgagccggc tgtagttgag cgggaacccg agacctggca gtcgccatga     60

ctggctgtcc ggcgtcatca agacgccgag gcttcgggct ctttttcttc ttgcgtctac    120

accgcctcct gttgttgttt ctggttttgc gtgggaccct ggccaacaaa cttaacgtgc    180

cacaggtgtt gctacccttc ggccgagagc caggccgggt gcctttcctg ctggaggccc    240

agcggggctg ctacacttgg tgaggggtgg tgggtgacaa ggatatgcac cctcactacc    300

atccagtaag ggcattccac ccatcatgat gcagttactg ttgagccttt atatgaaaat    360

ggcaccttgt gttcccaaaa agctgtactc attgctgaat ctacgcaacc gatacgcctc    420

agcagtatta ttcttgctcg agaaatagtg actgaccatg agctacgctg tgatgttaag    480

gttgatgtga taaacagcat tgaaattgta tctcgggccc gggaacttta tgtagatgat    540

tcgccact                                                             548


<210>  905
<211>  68
<212>  PRT
<213>  Homo sapiens

<400>  905


Met Thr Gly Cys Pro Ala Ser Ser Arg Arg Arg Gly Phe Gly Leu Phe 
1               5                   10                  15      


Phe Phe Leu Arg Leu His Arg Leu Leu Leu Leu Phe Leu Val Leu Arg 
            20                  25                  30          


Gly Thr Leu Ala Asn Lys Leu Asn Val Pro Gln Val Leu Leu Pro Phe 
        35                  40                  45              


Gly Arg Glu Pro Gly Arg Val Pro Phe Leu Leu Glu Ala Gln Arg Gly 
    50                  55                  60                  


Cys Tyr Thr Trp 
65              

<210>  906
<211>  4934
<212>  DNA
<213>  Homo sapiens

<400>  906
caggtagcag ttatgacttg ttcctggtag tggatttctc tcaagtgctt tattagtatt     60

caaacatttt tgagcccagg aaggtctagc tcctgacacg ttctatggta gagggaggag    120

ggttgatgct tgctcaggtt acttgggaac atctcttccc cagtatgcct tccaactctc    180

tctacatata ggttcaattc acgtctatgt gtctctctcc ctttttttat tctcttcctt    240

ttcccttttc ctctcctgtg gtatttaaaa tattcacagt aagtgttctg agctggagga    300

ggagctgaag aatgtcacca acaacctcaa gtctcttgag gctcaggcgg agaaggtagg    360

ggctggtttg tgaaagtgac aggctttggg gcctgggccc agccctgccc ttgatgaaag    420

actggagaca cgcattccat atataatcca gtgaggcgtg tcctcttcct acctccttac    480

catgtattca ggttctgggt ttaatgctat tttctgtgca ctttgattgc tttaattaaa    540

ataacttctt ggtctcaggt tactggagtc atgtgctcct taggctgata ctgctgtgct    600

gaaaagcaat aatcaagggc cctaacaggc tttctagcag acagatgggg gcaacagaca    660

gaatcagctc tgagacctaa tgagcaatca agacagatga cttcactttg ccatcatgtg    720

ggtgtgtttc agtcatgtga ccttggggtg ctactactct tgctcatcaa gcaggggaaa    780

ggaaaaacac ctccttgggt tgatctgaat aatatcaaag cttagatcca tcttaaaaag    840

tcatggagaa ttttaacctg aggatctcat ggctctaaag acatagattt ctgaatttca    900

aggacctatt gtccagagcc aggccttgct cttactcttg gaccattcag cacatttagt    960

gcaagaggat attcaatgta agttaaatgt agggaggggg gtattgcctg tgtgactaat   1020

ttctactctg aaatttttaa tctacttatc ttacagtact ctcaaaaaga agataaatat   1080

gaggaagaaa tcaagattct tactgataaa ctcaaggagg cagagacccg tgctgagttt   1140

gctgagagat cggtagccaa gctggaaaag acaattgatg acctggaaga gcgtctctac   1200

agccaacttg agcgaaaccg cctgctttct aatgagctga agctaacgct gcatgatctg   1260

tgtgactgat gggcagggct caatgatgcc cattaaactg agcttactgc tcacaccact   1320

gacctggacc ccaacaaaaa gctgattgtc tttttaaaag ttattatttt gccctgagca   1380

aattgcattt taattggggc agttagaatg ttgatttcct aacagcattg tgaagttgac   1440

cattgtgaag tttctgtccc tttagaagag attatgggtg aagaagggag gggcctgaga   1500

gattatagtg agaaaacttg cgagaatttt gttttccacc cttatttgct gctctttcac   1560

ttgggcactg actgtaggat atgttccctt gcatggatgt ttttaacaat aaaaggactg   1620

acttgacaag ttgttgtaac tgcttcatcg gcaggcccag gaatgggtcc ttctgactgg   1680

gtggaaaaaa gggaagtgaa agaaaagttg tgggatatga atatgggtct gtgttgccat   1740

caccttctct gagttgaaga tttgagtatt ttcctcacct ctttagagca gtcagagtgg   1800

tttgcttgct agacagatta gattctcctt aatgttcagc tgctgatttt ctttctgact   1860

tttgcgtcct ttttctggtt ttatgttaat ttcaagtaac tgtcacaagc tagttctgtt   1920

caatagctct gcagcaatct caaggtttgc ttacaactac ttgtttcagt agtattcttg   1980

gctttgtttt ctttagagat tatttgactt aactgtgagc gcccttttat ttatcccatc   2040

agttattact ttggcctcta ctttttcgaa aaaacatgta gtgcatgagg atcttcctgt   2100

gctctttata atctgagatt ctgatgtttc tattgtttgc aatgttcaaa ctccggtgag   2160

ccatttcaag agggtattgt tatgtgggca aaacctagaa aagtggatgg ctgatggtta   2220

aggcttgctc tttcattgac tgaaagctga aagtgttggt tgggtgtggg agggagagga   2280

aatggctgat aagggcccta actccctcac ccaggaagtg cagcaacacc tacaacttca   2340

gtaggcaagc caaaggccct acaaaactgg gtgatgtaat agctcacttc tgtggctgag   2400

aaggcagctg ctttatcagt ctgcagcttc tctgcaacag gagcaagtct caaagagcgg   2460

gtagaccttg aaatttactt ctagttcttg taacttctct cctttacccc cattagataa   2520

actgaaatgc accaaagagg agcacctctg tacacaaagg atgctggacc agaccctgct   2580

tgacctgaat gagatgtaga acgccccagt cccaccctgc tgctgctcct ccctctgacc   2640

cagactccgc ctgaggccag cctgcgggaa gctgaccttt aactgagggc tgatctttaa   2700

ctggaaggct gctttctcct ttcaccaccc cctccttccc tgtgtctttt tcgccaaact   2760

gtctctgcct cttcccggag aatccagctg ggctagaggc tgagcacctt tggaaacaac   2820

atttaaggga atgtgagcac aatgcataat gtctttaaaa agcatgttgt gatgtacaca   2880

ttttgtaatt accttttttg ttgttttgta gcaaccattt gtaaaacatt ccaaataatt   2940

ccacagtcct gaagcagcaa tcgaatccct ttctcacttt tggaaggtga cttttcacct   3000

taatgcatat tcccctctcc atagaggaga ggaaaaggtg taggcctgcc ttaccgagag   3060

ccaaacagag cccagggaga ctccgctgtg ggaaacctca ttgttctgta caaagtacta   3120

gctaaaccag aaaggtgatt ccaggaggag ttagccaaac aacaacaaaa acaaaaaatg   3180

tgctgttcaa gttttcagct ttaagatatc tttggataat gttatttcta ttttttattt   3240

ttttcattag aagttaccaa attaagatgg taagacctct gagaccaaaa ttttgtccca   3300

tctctacccc ctcacaactg cttacagaat ggatcatgtc ccccttatgt tgaggtgacc   3360

acttaattgc tttcctgcct ccttgaaaga aagaaagaaa gaagactgtg tttttgccac   3420

tgatttagcc atgtgaaact catctcatta cccttttctg ggtttgaagc tgctgtctct   3480

agaagtgcca tctcaattgt gctttgtatc agtcagtgct ggagaaatct tgaatagctt   3540

atgtacaaaa ctttttaaat tttatattat tttgaaactt tgctttgggt ttgtggcacc   3600

ctggccaccc catctggctg tgacagcctc tgcagtccgt gggctggcag tttgttgatc   3660

ttttaagttt ccttccctac ccagtcccca ttttctggta aggtttctag gaggtctgtt   3720

aggtgtacat cctgcagctt attggcttaa aatgtactct ccttttatgt ggtctctttg   3780

gggccgattg ggagaaagag aaatcaatag tgcaactgtt ttgatactga atattgacaa   3840

gtgtcttttt gaaataaaga accagtccct ccaaccctca gacctatttg acttttattt   3900

attaaaacta aatgtgcttt ctccacagaa gctatgaggt ttgggttaaa aatagcatct   3960

ttgtgggtgg tagcaacagg atttattctt tattattatt atttttgaga tgaagtttca   4020

ttcttgttgc ctgggctgga gcgtaatggc tcgatctcgg ctcactgcaa cctccgcctc   4080

ctggttcaag agattctcct gcctcagcct cccgagtagc tgggattaca ggcacctgcc   4140

accatgcccg ggtaattttt tatattttaa gtagagacag ggcttcacca tgttggccag   4200

gctggtctcg aactcctgac cttcaggtga tccacctgcc tcagcttccc aaaatgctgg   4260

gattacgggc gtgagccacc gcacccagct ggagcaacag gatttaatat agagcaaatg   4320

tttagtttta tcatctgtaa aatggagata agtattgtca gagtaaacat gaagattaga   4380

aagaacactt aatgtgctgg gccttttata ggttaacact gacatctcag gctgaactat   4440

atacattttc cttcacaacc atatcaatcc ttataaacta tggatttatg ctccttaaaa   4500

caatatataa tgctgatcac tactataaat gcgtggtttt aaccaactgt actgaaacag   4560

ctttgagttt atattctgtt tggatatttg gagaaaacaa caagtgctct caagagtatt   4620

tgcttagagg ccggctgtgt gagtggataa ctttgaaagc tgcttttgag acgccagtgt   4680

ctggcatttc ctgcattctg gcctggaggc cggacgtgaa tctgacttct agtaaaaata   4740

cacggttccc ttgacaaagt cgagctgttt atcccagaga ctgcacaatt ttccgttgat   4800

aggcatggac caatgctaac tggaaatcat tgcaaaaagt ttttttgtcg ggcggagggt   4860

gtggtgttaa gataaacagt gtgcaacaga agaaattaaa actggaagaa attaaagggt   4920

tttttttaga cttt                                                     4934


<210>  907
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  907


Met Cys Trp Ala Phe Tyr Arg Leu Thr Leu Thr Ser Gln Ala Glu Leu 
1               5                   10                  15      


Tyr Thr Phe Ser Phe Thr Thr Ile Ser Ile Leu Ile Asn Tyr Gly Phe 
            20                  25                  30          


Met Leu Leu Lys Thr Ile Tyr Asn Ala Asp His Tyr Tyr Lys Cys Val 
        35                  40                  45              


Val Leu Thr Asn Cys Thr Glu Thr Ala Leu Ser Leu Tyr Ser Val Trp 
    50                  55                  60                  


Ile Phe Gly Glu Asn Asn Lys Cys Ser Gln Glu Tyr Leu Leu Arg Gly 
65                  70                  75                  80  


Arg Leu Cys Glu Trp Ile Thr Leu Lys Ala Ala Phe Glu Thr Pro Val 
                85                  90                  95      


Ser Gly Ile Ser Cys Ile Leu Ala Trp Arg Pro Asp Val Asn Leu Thr 
            100                 105                 110         


Ser Ser Lys Asn Thr Arg Phe Pro 
        115                 120 

<210>  908
<211>  3528
<212>  DNA
<213>  Homo sapiens

<400>  908
caggtagcag ttatgacttg ttcctggtag tggatttctc tcaagtgctt tattagtatt     60

caaacatttt tgagcccagg aaggtctagc tcctgacacg ttctatggta gagggaggag    120

ggttgatgct tgctcaggtt acttgggaac atctcttccc cagtatgcct tccaactctc    180

tctacatata ggttcaattc acgtctatgt gtctctctcc ctttttttat tctcttcctt    240

ttcccttttc ctctcctgtg gtatttaaaa tattcacagt aagtgttctg agctggagga    300

ggagctgaag aatgtcacca acaacctcaa gtctcttgag gctcaggcgg agaaggtagg    360

ggctggtttg tgaaagtgac aggctttggg gcctgggccc agccctgccc ttgatgaaag    420

actggagaca cgcattccat atataatcca gtgaggcgtg tcctcttcct acctccttac    480

catgtattca ggttctgggt ttaatgctat tttctgtgca ctttgattgc tttaattaaa    540

ataacttctt ggtctcaggt tactggagtc atgtgctcct taggctgata ctgctgtgct    600

gaaaagcaat aatcaagggc cctaacaggc tttctagcag acagatgggg gcaacagaca    660

gaatcagctc tgagacctaa tgagcaatca agacagatga cttcactttg ccatcatgtg    720

ggtgtgtttc agtcatgtga ccttggggtg ctactactct tgctcatcaa gcaggggaaa    780

ggaaaaacac ctccttgggt tgatctgaat aatatcaaag cttagatcca tcttaaaaag    840

tcatggagaa ttttaacctg aggatctcat ggctctaaag acatagattt ctgaatttca    900

aggacctatt gtccagagcc aggccttgct cttactcttg gaccattcag cacatttagt    960

gcaagaggat attcaattac tctcaaaaag aagataaata tgaggaagaa atcaagattc   1020

ttactgataa actcaaggag gcagagaccc gtgctgagtt tgctgagaga tcggtagcca   1080

agctggaaaa gacaattgat gacctggaag ataaactgaa atgcaccaaa gaggagcacc   1140

tctgtacaca aaggatgctg gaccagaccc tgcttgacct gaatgagatg tagaacgccc   1200

cagtcccacc ctgctgctgc tcctccctct gacccagact ccgcctgagg ccagcctgcg   1260

ggaagctgac ctttaactga gggctgatct ttaactggaa ggctgctttc tcctttcacc   1320

accccctcct tccctgtgtc tttttcgcca aactgtctct gcctcttccc ggagaatcca   1380

gctgggctag aggctgagca cctttggaaa caacatttaa gggaatgtga gcacaatgca   1440

taatgtcttt aaaaagcatg ttgtgatgta cacattttgt aattaccttt tttgttgttt   1500

tgtagcaacc atttgtaaaa cattccaaat aattccacag tcctgaagca gcaatcgaat   1560

ccctttctca cttttggaag gtgacttttc accttaatgc atattcccct ctccatagag   1620

gagaggaaaa ggtgtaggcc tgccttaccg agagccaaac agagcccagg gagactccgc   1680

tgtgggaaac ctcattgttc tgtacaaagt actagctaaa ccagaaaggt gattccagga   1740

ggagttagcc aaacaacaac aaaaacaaaa aatgtgctgt tcaagttttc agctttaaga   1800

tatctttgga taatgttatt tctatttttt atttttttca ttagaagtta ccaaattaag   1860

atggtaagac ctctgagacc aaaattttgt cccatctcta ccccctcaca actgcttaca   1920

gaatggatca tgtccccctt atgttgaggt gaccacttaa ttgctttcct gcctccttga   1980

aagaaagaaa gaaagaagac tgtgtttttg ccactgattt agccatgtga aactcatctc   2040

attacccttt tctgggtttg aagctgctgt ctctagaagt gccatctcaa ttgtgctttg   2100

tatcagtcag tgctggagaa atcttgaata gcttatgtac aaaacttttt aaattttata   2160

ttattttgaa actttgcttt gggtttgtgg caccctggcc accccatctg gctgtgacag   2220

cctctgcagt ccgtgggctg gcagtttgtt gatcttttaa gtttccttcc ctacccagtc   2280

cccattttct ggtaaggttt ctaggaggtc tgttaggtgt acatcctgca gcttattggc   2340

ttaaaatgta ctctcctttt atgtggtctc tttggggccg attgggagaa agagaaatca   2400

atagtgcaac tgttttgata ctgaatattg acaagtgtct ttttgaaata aagaaccagt   2460

ccctccaacc ctcagaccta tttgactttt atttattaaa actaaatgtg ctttctccac   2520

agaagctatg aggtttgggt taaaaatagc atctttgtgg gtggtagcaa caggatttat   2580

tctttattat tattattttt gagatgaagt ttcattcttg ttgcctgggc tggagcgtaa   2640

tggctcgatc tcggctcact gcaacctccg cctcctggtt caagagattc tcctgcctca   2700

gcctcccgag tagctgggat tacaggcacc tgccaccatg cccgggtaat tttttatatt   2760

ttaagtagag acagggcttc accatgttgg ccaggctggt ctcgaactcc tgaccttcag   2820

gtgatccacc tgcctcagct tcccaaaatg ctgggattac gggcgtgagc caccgcaccc   2880

agctggagca acaggattta atatagagca aatgtttagt tttatcatct gtaaaatgga   2940

gataagtatt gtcagagtaa acatgaagat tagaaagaac acttaatgtg ctgggccttt   3000

tataggttaa cactgacatc tcaggctgaa ctatatacat tttccttcac aaccatatca   3060

atccttataa actatggatt tatgctcctt aaaacaatat ataatgctga tcactactat   3120

aaatgcgtgg ttttaaccaa ctgtactgaa acagctttga gtttatattc tgtttggata   3180

tttggagaaa acaacaagtg ctctcaagag tatttgctta gaggccggct gtgtgagtgg   3240

ataactttga aagctgcttt tgagacgcca gtgtctggca tttcctgcat tctggcctgg   3300

aggccggacg tgaatctgac ttctagtaaa aatacacggt tcccttgaca aagtcgagct   3360

gtttatccca gagactgcac aattttccgt tgataggcat ggaccaatgc taactggaaa   3420

tcattgcaaa aagttttttt gtcgggcgga gggtgtggtg ttaagataaa cagtgtgcaa   3480

cagaagaaat taaaactgga agaaattaaa gggttttttt tagacttt                3528


<210>  909
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  909


Met Cys Trp Ala Phe Tyr Arg Leu Thr Leu Thr Ser Gln Ala Glu Leu 
1               5                   10                  15      


Tyr Thr Phe Ser Phe Thr Thr Ile Ser Ile Leu Ile Asn Tyr Gly Phe 
            20                  25                  30          


Met Leu Leu Lys Thr Ile Tyr Asn Ala Asp His Tyr Tyr Lys Cys Val 
        35                  40                  45              


Val Leu Thr Asn Cys Thr Glu Thr Ala Leu Ser Leu Tyr Ser Val Trp 
    50                  55                  60                  


Ile Phe Gly Glu Asn Asn Lys Cys Ser Gln Glu Tyr Leu Leu Arg Gly 
65                  70                  75                  80  


Arg Leu Cys Glu Trp Ile Thr Leu Lys Ala Ala Phe Glu Thr Pro Val 
                85                  90                  95      


Ser Gly Ile Ser Cys Ile Leu Ala Trp Arg Pro Asp Val Asn Leu Thr 
            100                 105                 110         


Ser Ser Lys Asn Thr Arg Phe Pro 
        115                 120 

<210>  910
<211>  3481
<212>  DNA
<213>  Homo sapiens

<400>  910
cattgaagga gacttggaac gcacagagga acgagctgag ctggcagagt cgtgagtatc     60

tagctcccca aatcttgtca ttaccaattt atcccttccc ctttggcttg ggcactaata    120

tgaataaatt agcattcctt caaccttgtt aaacagggcc tagggaatgg gagtcatcta    180

tagtgctttt ttaggcccaa gaatggtttt aggcttcctt attctcctga ctagtgacaa    240

gtgacaaaag aggctttctt attttttgtt ggtagggttt acaaattgag agcaaataag    300

gactaataca tggtgaacag ttaattggaa gatcctactg ggtccttcca cctggggtgg    360

aagacatcaa agtggctatc ctgatttaag atctagtgtc tggctgggtg tggtggctca    420

aacctgtagt cccagctact tagtatgcca aggcaggaag gttgcttgaa cccaggagtt    480

ggaggccagc ctgggcgtca tagggagacc ctgtccctaa aacaaataaa tttaaaaaaa    540

aaatctggtg tctgttttgg ccactttgcc aatctgctag ggaaccttag ggcaagggta    600

gatattaact gctctcccgt cggtaccttc tgggccttga ttaacaaagt cagtgctgaa    660

tgcatatgta tttgtgcttc cctcttacat tcccgtctgc cagacataac atatcatgac    720

catggtggtg ttctcttccc attttttgaa tttttttttt tcgttttgct gcttgttttc    780

ttgctgtgtt cctttttgac ctttctccct ccccacaacc tggcttgtgc catccccgtg    840

actatcacta acagccgttg ccgagagatg gatgagcaga ttagactgat ggaccagaac    900

ctgaagtgtc tgagtgctgc tgaagaaaag tactctcaaa aagaagataa atatgaggaa    960

gaaatcaaga ttcttactga taaactcaag gaggcagaga cccgtgctga gtttgctgag   1020

agatcggtag ccaagctgga aaagacaatt gatgacctgg aagataaact gaaatgcacc   1080

aaagaggagc acctctgtac acaaaggatg ctggaccaga ccctgcttga cctgaatgag   1140

atgtagaacg ccccagtccc accctgctgc tgctcctccc tctgacccag actccgcctg   1200

aggccagcct gcgggaagct gacctttaac tgagggctga tctttaactg gaaggctgct   1260

ttctcctttc accaccccct ccttccctgt gtctttttcg ccaaactgtc tctgcctctt   1320

cccggagaat ccagctgggc tagaggctga gcacctttgg aaacaacatt taagggaatg   1380

tgagcacaat gcataatgtc tttaaaaagc atgttgtgat gtacacattt tgtaattacc   1440

ttttttgttg ttttgtagca accatttgta aaacattcca aataattcca cagtcctgaa   1500

gcagcaatcg aatccctttc tcacttttgg aaggtgactt ttcaccttaa tgcatattcc   1560

cctctccata gaggagagga aaaggtgtag gcctgcctta ccgagagcca aacagagccc   1620

agggagactc cgctgtggga aacctcattg ttctgtacaa agtactagct aaaccagaaa   1680

ggtgattcca ggaggagtta gccaaacaac aacaaaaaca aaaaatgtgc tgttcaagtt   1740

ttcagcttta agatatcttt ggataatgtt atttctattt tttatttttt tcattagaag   1800

ttaccaaatt aagatggtaa gacctctgag accaaaattt tgtcccatct ctaccccctc   1860

acaactgctt acagaatgga tcatgtcccc cttatgttga ggtgaccact taattgcttt   1920

cctgcctcct tgaaagaaag aaagaaagaa gactgtgttt ttgccactga tttagccatg   1980

tgaaactcat ctcattaccc ttttctgggt ttgaagctgc tgtctctaga agtgccatct   2040

caattgtgct ttgtatcagt cagtgctgga gaaatcttga atagcttatg tacaaaactt   2100

tttaaatttt atattatttt gaaactttgc tttgggtttg tggcaccctg gccaccccat   2160

ctggctgtga cagcctctgc agtccgtggg ctggcagttt gttgatcttt taagtttcct   2220

tccctaccca gtccccattt tctggtaagg tttctaggag gtctgttagg tgtacatcct   2280

gcagcttatt ggcttaaaat gtactctcct tttatgtggt ctctttgggg ccgattggga   2340

gaaagagaaa tcaatagtgc aactgttttg atactgaata ttgacaagtg tctttttgaa   2400

ataaagaacc agtccctcca accctcagac ctatttgact tttatttatt aaaactaaat   2460

gtgctttctc cacagaagct atgaggtttg ggttaaaaat agcatctttg tgggtggtag   2520

caacaggatt tattctttat tattattatt tttgagatga agtttcattc ttgttgcctg   2580

ggctggagcg taatggctcg atctcggctc actgcaacct ccgcctcctg gttcaagaga   2640

ttctcctgcc tcagcctccc gagtagctgg gattacaggc acctgccacc atgcccgggt   2700

aattttttat attttaagta gagacagggc ttcaccatgt tggccaggct ggtctcgaac   2760

tcctgacctt caggtgatcc acctgcctca gcttcccaaa atgctgggat tacgggcgtg   2820

agccaccgca cccagctgga gcaacaggat ttaatataga gcaaatgttt agttttatca   2880

tctgtaaaat ggagataagt attgtcagag taaacatgaa gattagaaag aacacttaat   2940

gtgctgggcc ttttataggt taacactgac atctcaggct gaactatata cattttcctt   3000

cacaaccata tcaatcctta taaactatgg atttatgctc cttaaaacaa tatataatgc   3060

tgatcactac tataaatgcg tggttttaac caactgtact gaaacagctt tgagtttata   3120

ttctgtttgg atatttggag aaaacaacaa gtgctctcaa gagtatttgc ttagaggccg   3180

gctgtgtgag tggataactt tgaaagctgc ttttgagacg ccagtgtctg gcatttcctg   3240

cattctggcc tggaggccgg acgtgaatct gacttctagt aaaaatacac ggttcccttg   3300

acaaagtcga gctgtttatc ccagagactg cacaattttc cgttgatagg catggaccaa   3360

tgctaactgg aaatcattgc aaaaagtttt tttgtcgggc ggagggtgtg gtgttaagat   3420

aaacagtgtg caacagaaga aattaaaact ggaagaaatt aaagggtttt ttttagactt   3480

t                                                                   3481


<210>  911
<211>  233
<212>  PRT
<213>  Homo sapiens

<400>  911


Met Pro Arg Gln Glu Gly Cys Leu Asn Pro Gly Val Gly Gly Gln Pro 
1               5                   10                  15      


Gly Arg His Arg Glu Thr Leu Ser Leu Lys Gln Ile Asn Leu Lys Lys 
            20                  25                  30          


Lys Ser Gly Val Cys Phe Gly His Phe Ala Asn Leu Leu Gly Asn Leu 
        35                  40                  45              


Arg Ala Arg Val Asp Ile Asn Cys Ser Pro Val Gly Thr Phe Trp Ala 
    50                  55                  60                  


Leu Ile Asn Lys Val Ser Ala Glu Cys Ile Cys Ile Cys Ala Ser Leu 
65                  70                  75                  80  


Leu His Ser Arg Leu Pro Asp Ile Thr Tyr His Asp His Gly Gly Val 
                85                  90                  95      


Leu Phe Pro Phe Phe Glu Phe Phe Phe Phe Val Leu Leu Leu Val Phe 
            100                 105                 110         


Leu Leu Cys Ser Phe Leu Thr Phe Leu Pro Pro His Asn Leu Ala Cys 
        115                 120                 125             


Ala Ile Pro Val Thr Ile Thr Asn Ser Arg Cys Arg Glu Met Asp Glu 
    130                 135                 140                 


Gln Ile Arg Leu Met Asp Gln Asn Leu Lys Cys Leu Ser Ala Ala Glu 
145                 150                 155                 160 


Glu Lys Tyr Ser Gln Lys Glu Asp Lys Tyr Glu Glu Glu Ile Lys Ile 
                165                 170                 175     


Leu Thr Asp Lys Leu Lys Glu Ala Glu Thr Arg Ala Glu Phe Ala Glu 
            180                 185                 190         


Arg Ser Val Ala Lys Leu Glu Lys Thr Ile Asp Asp Leu Glu Asp Lys 
        195                 200                 205             


Leu Lys Cys Thr Lys Glu Glu His Leu Cys Thr Gln Arg Met Leu Asp 
    210                 215                 220                 


Gln Thr Leu Leu Asp Leu Asn Glu Met 
225                 230             

<210>  912
<211>  2784
<212>  DNA
<213>  Homo sapiens

<400>  912
tgaagaggtg gctcgtaagt tggtgatcat tgaaggagac ttggaacgca cagaggaacg     60

agctgagctg gcagagtccc gttgccgaga gatggatgag cagattagac tgatggacca    120

gaacctgaag tgtctgagtg ctgctgaaga aaagtactct caaaaagaag ataaatatga    180

ggaagaaatc aagattctta ctgataaact caaggaggca gagacccgtg ctgagtttgc    240

tgagagatcg gtagccaagc tggaaaagac aattgatgac ctggaagatg agctctatgc    300

ccagaaactg aagtacaagg ccattagcga ggagctggac cacgccctca atgacatgac    360

ctctatataa actgaaatgc accaaagagg agcacctctg tacacaaagg atgctggacc    420

agaccctgct tgacctgaat gagatgtaga acgccccagt cccaccctgc tgctgctcct    480

ccctctgacc cagactccgc ctgaggccag cctgcgggaa gctgaccttt aactgagggc    540

tgatctttaa ctggaaggct gctttctcct ttcaccaccc cctccttccc tgtgtctttt    600

tcgccaaact gtctctgcct cttcccggag aatccagctg ggctagaggc tgagcacctt    660

tggaaacaac atttaaggga atgtgagcac aatgcataat gtctttaaaa agcatgttgt    720

gatgtacaca ttttgtaatt accttttttg ttgttttgta gcaaccattt gtaaaacatt    780

ccaaataatt ccacagtcct gaagcagcaa tcgaatccct ttctcacttt tggaaggtga    840

cttttcacct taatgcatat tcccctctcc atagaggaga ggaaaaggtg taggcctgcc    900

ttaccgagag ccaaacagag cccagggaga ctccgctgtg ggaaacctca ttgttctgta    960

caaagtacta gctaaaccag aaaggtgatt ccaggaggag ttagccaaac aacaacaaaa   1020

acaaaaaatg tgctgttcaa gttttcagct ttaagatatc tttggataat gttatttcta   1080

ttttttattt ttttcattag aagttaccaa attaagatgg taagacctct gagaccaaaa   1140

ttttgtccca tctctacccc ctcacaactg cttacagaat ggatcatgtc ccccttatgt   1200

tgaggtgacc acttaattgc tttcctgcct ccttgaaaga aagaaagaaa gaagactgtg   1260

tttttgccac tgatttagcc atgtgaaact catctcatta cccttttctg ggtttgaagc   1320

tgctgtctct agaagtgcca tctcaattgt gctttgtatc agtcagtgct ggagaaatct   1380

tgaatagctt atgtacaaaa ctttttaaat tttatattat tttgaaactt tgctttgggt   1440

ttgtggcacc ctggccaccc catctggctg tgacagcctc tgcagtccgt gggctggcag   1500

tttgttgatc ttttaagttt ccttccctac ccagtcccca ttttctggta aggtttctag   1560

gaggtctgtt aggtgtacat cctgcagctt attggcttaa aatgtactct ccttttatgt   1620

ggtctctttg gggccgattg ggagaaagag aaatcaatag tgcaactgtt ttgatactga   1680

atattgacaa gtgtcttttt gaaataaaga accagtccct ccaaccctca gacctatttg   1740

acttttattt attaaaacta aatgtgcttt ctccacagaa gctatgaggt ttgggttaaa   1800

aatagcatct ttgtgggtgg tagcaacagg atttattctt tattattatt atttttgaga   1860

tgaagtttca ttcttgttgc ctgggctgga gcgtaatggc tcgatctcgg ctcactgcaa   1920

cctccgcctc ctggttcaag agattctcct gcctcagcct cccgagtagc tgggattaca   1980

ggcacctgcc accatgcccg ggtaattttt tatattttaa gtagagacag ggcttcacca   2040

tgttggccag gctggtctcg aactcctgac cttcaggtga tccacctgcc tcagcttccc   2100

aaaatgctgg gattacgggc gtgagccacc gcacccagct ggagcaacag gatttaatat   2160

agagcaaatg tttagtttta tcatctgtaa aatggagata agtattgtca gagtaaacat   2220

gaagattaga aagaacactt aatgtgctgg gccttttata ggttaacact gacatctcag   2280

gctgaactat atacattttc cttcacaacc atatcaatcc ttataaacta tggatttatg   2340

ctccttaaaa caatatataa tgctgatcac tactataaat gcgtggtttt aaccaactgt   2400

actgaaacag ctttgagttt atattctgtt tggatatttg gagaaaacaa caagtgctct   2460

caagagtatt tgcttagagg ccggctgtgt gagtggataa ctttgaaagc tgcttttgag   2520

acgccagtgt ctggcatttc ctgcattctg gcctggaggc cggacgtgaa tctgacttct   2580

agtaaaaata cacggttccc ttgacaaagt cgagctgttt atcccagaga ctgcacaatt   2640

ttccgttgat aggcatggac caatgctaac tggaaatcat tgcaaaaagt ttttttgtcg   2700

ggcggagggt gtggtgttaa gataaacagt gtgcaacaga agaaattaaa actggaagaa   2760

attaaagggt tttttttaga cttt                                          2784


<210>  913
<211>  92
<212>  PRT
<213>  Homo sapiens

<400>  913


Met Asp Glu Gln Ile Arg Leu Met Asp Gln Asn Leu Lys Cys Leu Ser 
1               5                   10                  15      


Ala Ala Glu Glu Lys Tyr Ser Gln Lys Glu Asp Lys Tyr Glu Glu Glu 
            20                  25                  30          


Ile Lys Ile Leu Thr Asp Lys Leu Lys Glu Ala Glu Thr Arg Ala Glu 
        35                  40                  45              


Phe Ala Glu Arg Ser Val Ala Lys Leu Glu Lys Thr Ile Asp Asp Leu 
    50                  55                  60                  


Glu Asp Glu Leu Tyr Ala Gln Lys Leu Lys Tyr Lys Ala Ile Ser Glu 
65                  70                  75                  80  


Glu Leu Asp His Ala Leu Asn Asp Met Thr Ser Ile 
                85                  90          

<210>  914
<211>  2953
<212>  DNA
<213>  Homo sapiens

<400>  914
caggctgagg ctgaggtggc ctccttgaac cgtaggatcc agctggttga agaagagctg     60

gaccgtgctc aggagcgcct ggccactgcc ctgcaaaagc tggaagaagc tgaaaaagct    120

gctgatgaga gtgagagagg tatgaaggtt attgaaaacc gggccttaaa agatgaagaa    180

aagatggaac tccaggaaat ccaactcaaa gaagctaagc acattgcaga agaggcagat    240

aggaagtatg aagaggtggc tcgtaagttg gtgatcattg aaggagactt ggaacgcaca    300

gaggaacgag ctgagctggc agagtcccgt tgccgagaga tggatgagca gattagactg    360

atggaccaga acctgaagtg tctgagtgct gctgaagaaa agtactctca aaaagaagat    420

aaatatgagg aagaaatcaa gattcttact gataaactca aggaggcaga gacccgtgct    480

gagtttgctg agagatcggt agccaagctg gaaaagacaa ttgatgacct ggaagataaa    540

ctgaaatgca ccaaagagga gcacctctgt acacaaagga tgctggacca gaccctgctt    600

gacctgaatg agatgtagaa cgccccagtc ccaccctgct gctgctcctc cctctgaccc    660

agactccgcc tgaggccagc ctgcgggaag ctgaccttta actgagggct gatctttaac    720

tggaaggctg ctttctcctt tcaccacccc ctccttccct gtgtcttttt cgccaaactg    780

tctctgcctc ttcccggaga atccagctgg gctagaggct gagcaccttt ggaaacaaca    840

tttaagggaa tgtgagcaca atgcataatg tctttaaaaa gcatgttgtg atgtacacat    900

tttgtaatta ccttttttgt tgttttgtag caaccatttg taaaacattc caaataattc    960

cacagtcctg aagcagcaat cgaatccctt tctcactttt ggaaggtgac ttttcacctt   1020

aatgcatatt cccctctcca tagaggagag gaaaaggtgt aggcctgcct taccgagagc   1080

caaacagagc ccagggagac tccgctgtgg gaaacctcat tgttctgtac aaagtactag   1140

ctaaaccaga aaggtgattc caggaggagt tagccaaaca acaacaaaaa caaaaaatgt   1200

gctgttcaag ttttcagctt taagatatct ttggataatg ttatttctat tttttatttt   1260

tttcattaga agttaccaaa ttaagatggt aagacctctg agaccaaaat tttgtcccat   1320

ctctaccccc tcacaactgc ttacagaatg gatcatgtcc cccttatgtt gaggtgacca   1380

cttaattgct ttcctgcctc cttgaaagaa agaaagaaag aagactgtgt ttttgccact   1440

gatttagcca tgtgaaactc atctcattac ccttttctgg gtttgaagct gctgtctcta   1500

gaagtgccat ctcaattgtg ctttgtatca gtcagtgctg gagaaatctt gaatagctta   1560

tgtacaaaac tttttaaatt ttatattatt ttgaaacttt gctttgggtt tgtggcaccc   1620

tggccacccc atctggctgt gacagcctct gcagtccgtg ggctggcagt ttgttgatct   1680

tttaagtttc cttccctacc cagtccccat tttctggtaa ggtttctagg aggtctgtta   1740

ggtgtacatc ctgcagctta ttggcttaaa atgtactctc cttttatgtg gtctctttgg   1800

ggccgattgg gagaaagaga aatcaatagt gcaactgttt tgatactgaa tattgacaag   1860

tgtctttttg aaataaagaa ccagtccctc caaccctcag acctatttga cttttattta   1920

ttaaaactaa atgtgctttc tccacagaag ctatgaggtt tgggttaaaa atagcatctt   1980

tgtgggtggt agcaacagga tttattcttt attattatta tttttgagat gaagtttcat   2040

tcttgttgcc tgggctggag cgtaatggct cgatctcggc tcactgcaac ctccgcctcc   2100

tggttcaaga gattctcctg cctcagcctc ccgagtagct gggattacag gcacctgcca   2160

ccatgcccgg gtaatttttt atattttaag tagagacagg gcttcaccat gttggccagg   2220

ctggtctcga actcctgacc ttcaggtgat ccacctgcct cagcttccca aaatgctggg   2280

attacgggcg tgagccaccg cacccagctg gagcaacagg atttaatata gagcaaatgt   2340

ttagttttat catctgtaaa atggagataa gtattgtcag agtaaacatg aagattagaa   2400

agaacactta atgtgctggg ccttttatag gttaacactg acatctcagg ctgaactata   2460

tacattttcc ttcacaacca tatcaatcct tataaactat ggatttatgc tccttaaaac   2520

aatatataat gctgatcact actataaatg cgtggtttta accaactgta ctgaaacagc   2580

tttgagttta tattctgttt ggatatttgg agaaaacaac aagtgctctc aagagtattt   2640

gcttagaggc cggctgtgtg agtggataac tttgaaagct gcttttgaga cgccagtgtc   2700

tggcatttcc tgcattctgg cctggaggcc ggacgtgaat ctgacttcta gtaaaaatac   2760

acggttccct tgacaaagtc gagctgttta tcccagagac tgcacaattt tccgttgata   2820

ggcatggacc aatgctaact ggaaatcatt gcaaaaagtt tttttgtcgg gcggagggtg   2880

tggtgttaag ataaacagtg tgcaacagaa gaaattaaaa ctggaagaaa ttaaagggtt   2940

ttttttagac ttt                                                      2953


<210>  915
<211>  158
<212>  PRT
<213>  Homo sapiens

<400>  915


Met Lys Val Ile Glu Asn Arg Ala Leu Lys Asp Glu Glu Lys Met Glu 
1               5                   10                  15      


Leu Gln Glu Ile Gln Leu Lys Glu Ala Lys His Ile Ala Glu Glu Ala 
            20                  25                  30          


Asp Arg Lys Tyr Glu Glu Val Ala Arg Lys Leu Val Ile Ile Glu Gly 
        35                  40                  45              


Asp Leu Glu Arg Thr Glu Glu Arg Ala Glu Leu Ala Glu Ser Arg Cys 
    50                  55                  60                  


Arg Glu Met Asp Glu Gln Ile Arg Leu Met Asp Gln Asn Leu Lys Cys 
65                  70                  75                  80  


Leu Ser Ala Ala Glu Glu Lys Tyr Ser Gln Lys Glu Asp Lys Tyr Glu 
                85                  90                  95      


Glu Glu Ile Lys Ile Leu Thr Asp Lys Leu Lys Glu Ala Glu Thr Arg 
            100                 105                 110         


Ala Glu Phe Ala Glu Arg Ser Val Ala Lys Leu Glu Lys Thr Ile Asp 
        115                 120                 125             


Asp Leu Glu Asp Lys Leu Lys Cys Thr Lys Glu Glu His Leu Cys Thr 
    130                 135                 140                 


Gln Arg Met Leu Asp Gln Thr Leu Leu Asp Leu Asn Glu Met 
145                 150                 155             

<210>  916
<211>  3345
<212>  DNA
<213>  Homo sapiens

<400>  916
attgtaaaga gaactgatcc tctgtgctag gagaaaagag aaaggcaagg tcccattccc     60

taccactcca ccctggaggg ggtctctgaa gctttttcta ggactcccat ctcaggttct    120

gcttttgata caggcttgtt catgtgtgca tgctcttagg agggcaccaa gatgtgtttt    180

ccccctctcc cttttcagcc ttgctaagaa ttctattgta aatgctgatt tgtgggagaa    240

actgcctgag ccagcttgct gtcatggcaa ctgtacaccc ccgccccata gcctgttatc    300

ttctactcca gtttgggtaa ctactggtga gctgcatgat gtcttacatt tcatgagctt    360

cctctaaatc tagttgtatt tttcgtctga ggggggctga ggctgaggtg gcctccttga    420

accgtaggat ccagctggtt gaagaagagc tggaccgtgc tcaggagcgc ctggccactg    480

ccctgcaaaa gctggaagaa gctgaaaaag ctgctgatga gagtgagaga ggtatgaagg    540

ttattgaaaa ccgggcctta aaagatgaag aaaagatgga actccaggaa atccaactca    600

aagaagctaa gcacattgca gaagaggcag ataggaagta tgaagaggtg gctcgtaagt    660

tggtgatcat tgaaggagac ttggaacgca cagaggaacg agctgagctg gcagagtcta    720

agtgttctga gctggaggag gagctgaaga atgtcaccaa caacctcaag tctcttgagg    780

ctcaggcgga gaagtactct caaaaagaag ataaatatga ggaagaaatc aagattctta    840

ctgataaact caaggaggca gagacccgtg ctgagtttgc tgagagatcg gtagccaagc    900

tggaaaagac aattgatgac ctggaagata aactgaaatg caccaaagag gagcacctct    960

gtacacaaag gatgctggac cagaccctgc ttgacctgaa tgagatgtag aacgccccag   1020

tcccaccctg ctgctgctcc tccctctgac ccagactccg cctgaggcca gcctgcggga   1080

agctgacctt taactgaggg ctgatcttta actggaaggc tgctttctcc tttcaccacc   1140

ccctccttcc ctgtgtcttt ttcgccaaac tgtctctgcc tcttcccgga gaatccagct   1200

gggctagagg ctgagcacct ttggaaacaa catttaaggg aatgtgagca caatgcataa   1260

tgtctttaaa aagcatgttg tgatgtacac attttgtaat tacctttttt gttgttttgt   1320

agcaaccatt tgtaaaacat tccaaataat tccacagtcc tgaagcagca atcgaatccc   1380

tttctcactt ttggaaggtg acttttcacc ttaatgcata ttcccctctc catagaggag   1440

aggaaaaggt gtaggcctgc cttaccgaga gccaaacaga gcccagggag actccgctgt   1500

gggaaacctc attgttctgt acaaagtact agctaaacca gaaaggtgat tccaggagga   1560

gttagccaaa caacaacaaa aacaaaaaat gtgctgttca agttttcagc tttaagatat   1620

ctttggataa tgttatttct attttttatt tttttcatta gaagttacca aattaagatg   1680

gtaagacctc tgagaccaaa attttgtccc atctctaccc cctcacaact gcttacagaa   1740

tggatcatgt cccccttatg ttgaggtgac cacttaattg ctttcctgcc tccttgaaag   1800

aaagaaagaa agaagactgt gtttttgcca ctgatttagc catgtgaaac tcatctcatt   1860

acccttttct gggtttgaag ctgctgtctc tagaagtgcc atctcaattg tgctttgtat   1920

cagtcagtgc tggagaaatc ttgaatagct tatgtacaaa actttttaaa ttttatatta   1980

ttttgaaact ttgctttggg tttgtggcac cctggccacc ccatctggct gtgacagcct   2040

ctgcagtccg tgggctggca gtttgttgat cttttaagtt tccttcccta cccagtcccc   2100

attttctggt aaggtttcta ggaggtctgt taggtgtaca tcctgcagct tattggctta   2160

aaatgtactc tccttttatg tggtctcttt ggggccgatt gggagaaaga gaaatcaata   2220

gtgcaactgt tttgatactg aatattgaca agtgtctttt tgaaataaag aaccagtccc   2280

tccaaccctc agacctattt gacttttatt tattaaaact aaatgtgctt tctccacaga   2340

agctatgagg tttgggttaa aaatagcatc tttgtgggtg gtagcaacag gatttattct   2400

ttattattat tatttttgag atgaagtttc attcttgttg cctgggctgg agcgtaatgg   2460

ctcgatctcg gctcactgca acctccgcct cctggttcaa gagattctcc tgcctcagcc   2520

tcccgagtag ctgggattac aggcacctgc caccatgccc gggtaatttt ttatatttta   2580

agtagagaca gggcttcacc atgttggcca ggctggtctc gaactcctga ccttcaggtg   2640

atccacctgc ctcagcttcc caaaatgctg ggattacggg cgtgagccac cgcacccagc   2700

tggagcaaca ggatttaata tagagcaaat gtttagtttt atcatctgta aaatggagat   2760

aagtattgtc agagtaaaca tgaagattag aaagaacact taatgtgctg ggccttttat   2820

aggttaacac tgacatctca ggctgaacta tatacatttt ccttcacaac catatcaatc   2880

cttataaact atggatttat gctccttaaa acaatatata atgctgatca ctactataaa   2940

tgcgtggttt taaccaactg tactgaaaca gctttgagtt tatattctgt ttggatattt   3000

ggagaaaaca acaagtgctc tcaagagtat ttgcttagag gccggctgtg tgagtggata   3060

actttgaaag ctgcttttga gacgccagtg tctggcattt cctgcattct ggcctggagg   3120

ccggacgtga atctgacttc tagtaaaaat acacggttcc cttgacaaag tcgagctgtt   3180

tatcccagag actgcacaat tttccgttga taggcatgga ccaatgctaa ctggaaatca   3240

ttgcaaaaag tttttttgtc gggcggaggg tgtggtgtta agataaacag tgtgcaacag   3300

aagaaattaa aactggaaga aattaaaggg ttttttttag acttt                   3345


<210>  917
<211>  158
<212>  PRT
<213>  Homo sapiens

<400>  917


Met Lys Val Ile Glu Asn Arg Ala Leu Lys Asp Glu Glu Lys Met Glu 
1               5                   10                  15      


Leu Gln Glu Ile Gln Leu Lys Glu Ala Lys His Ile Ala Glu Glu Ala 
            20                  25                  30          


Asp Arg Lys Tyr Glu Glu Val Ala Arg Lys Leu Val Ile Ile Glu Gly 
        35                  40                  45              


Asp Leu Glu Arg Thr Glu Glu Arg Ala Glu Leu Ala Glu Ser Lys Cys 
    50                  55                  60                  


Ser Glu Leu Glu Glu Glu Leu Lys Asn Val Thr Asn Asn Leu Lys Ser 
65                  70                  75                  80  


Leu Glu Ala Gln Ala Glu Lys Tyr Ser Gln Lys Glu Asp Lys Tyr Glu 
                85                  90                  95      


Glu Glu Ile Lys Ile Leu Thr Asp Lys Leu Lys Glu Ala Glu Thr Arg 
            100                 105                 110         


Ala Glu Phe Ala Glu Arg Ser Val Ala Lys Leu Glu Lys Thr Ile Asp 
        115                 120                 125             


Asp Leu Glu Asp Lys Leu Lys Cys Thr Lys Glu Glu His Leu Cys Thr 
    130                 135                 140                 


Gln Arg Met Leu Asp Gln Thr Leu Leu Asp Leu Asn Glu Met 
145                 150                 155             

<210>  918
<211>  3007
<212>  DNA
<213>  Homo sapiens

<400>  918
gcacggtcct ctgaaggccg gcgggctcgg agatgaagtt gggatctcgg aggatgggct     60

gaggctgagg tggcctcctt gaaccgtagg atccagctgg ttgaagaaga gctggaccgt    120

gctcaggagc gcctggccac tgccctgcaa aagctggaag aagctgaaaa agctgctgat    180

gagagtgaga gaggtatgaa ggttattgaa aaccgggcct taaaagatga agaaaagatg    240

gaactccagg aaatccaact caaagaagct aagcacattg cagaagaggc agataggaag    300

tatgaagagg tggctcgtaa gttggtgatc attgaaggag acttggaacg cacagaggaa    360

cgagctgagc tggcagagtc ccgttgccga gagatggatg agcagattag actgatggac    420

cagaacctga agtgtctgag tgctgctgaa gaaaagtact ctcaaaaaga agataaatat    480

gaggaagaaa tcaagattct tactgataaa ctcaaggagg cagagacccg tgctgagttt    540

gctgagagat cggtagccaa gctggaaaag acaattgatg acctggaaga taaactgaaa    600

tgcaccaaag aggagcacct ctgtacacaa aggatgctgg accagaccct gcttgacctg    660

aatgagatgt agaacgcccc agtcccaccc tgctgctgct cctccctctg acccagactc    720

cgcctgaggc cagcctgcgg gaagctgacc tttaactgag ggctgatctt taactggaag    780

gctgctttct cctttcacca ccccctcctt ccctgtgtct ttttcgccaa actgtctctg    840

cctcttcccg gagaatccag ctgggctaga ggctgagcac ctttggaaac aacatttaag    900

ggaatgtgag cacaatgcat aatgtcttta aaaagcatgt tgtgatgtac acattttgta    960

attacctttt ttgttgtttt gtagcaacca tttgtaaaac attccaaata attccacagt   1020

cctgaagcag caatcgaatc cctttctcac ttttggaagg tgacttttca ccttaatgca   1080

tattcccctc tccatagagg agaggaaaag gtgtaggcct gccttaccga gagccaaaca   1140

gagcccaggg agactccgct gtgggaaacc tcattgttct gtacaaagta ctagctaaac   1200

cagaaaggtg attccaggag gagttagcca aacaacaaca aaaacaaaaa atgtgctgtt   1260

caagttttca gctttaagat atctttggat aatgttattt ctatttttta tttttttcat   1320

tagaagttac caaattaaga tggtaagacc tctgagacca aaattttgtc ccatctctac   1380

cccctcacaa ctgcttacag aatggatcat gtccccctta tgttgaggtg accacttaat   1440

tgctttcctg cctccttgaa agaaagaaag aaagaagact gtgtttttgc cactgattta   1500

gccatgtgaa actcatctca ttaccctttt ctgggtttga agctgctgtc tctagaagtg   1560

ccatctcaat tgtgctttgt atcagtcagt gctggagaaa tcttgaatag cttatgtaca   1620

aaacttttta aattttatat tattttgaaa ctttgctttg ggtttgtggc accctggcca   1680

ccccatctgg ctgtgacagc ctctgcagtc cgtgggctgg cagtttgttg atcttttaag   1740

tttccttccc tacccagtcc ccattttctg gtaaggtttc taggaggtct gttaggtgta   1800

catcctgcag cttattggct taaaatgtac tctcctttta tgtggtctct ttggggccga   1860

ttgggagaaa gagaaatcaa tagtgcaact gttttgatac tgaatattga caagtgtctt   1920

tttgaaataa agaaccagtc cctccaaccc tcagacctat ttgactttta tttattaaaa   1980

ctaaatgtgc tttctccaca gaagctatga ggtttgggtt aaaaatagca tctttgtggg   2040

tggtagcaac aggatttatt ctttattatt attatttttg agatgaagtt tcattcttgt   2100

tgcctgggct ggagcgtaat ggctcgatct cggctcactg caacctccgc ctcctggttc   2160

aagagattct cctgcctcag cctcccgagt agctgggatt acaggcacct gccaccatgc   2220

ccgggtaatt ttttatattt taagtagaga cagggcttca ccatgttggc caggctggtc   2280

tcgaactcct gaccttcagg tgatccacct gcctcagctt cccaaaatgc tgggattacg   2340

ggcgtgagcc accgcaccca gctggagcaa caggatttaa tatagagcaa atgtttagtt   2400

ttatcatctg taaaatggag ataagtattg tcagagtaaa catgaagatt agaaagaaca   2460

cttaatgtgc tgggcctttt ataggttaac actgacatct caggctgaac tatatacatt   2520

ttccttcaca accatatcaa tccttataaa ctatggattt atgctcctta aaacaatata   2580

taatgctgat cactactata aatgcgtggt tttaaccaac tgtactgaaa cagctttgag   2640

tttatattct gtttggatat ttggagaaaa caacaagtgc tctcaagagt atttgcttag   2700

aggccggctg tgtgagtgga taactttgaa agctgctttt gagacgccag tgtctggcat   2760

ttcctgcatt ctggcctgga ggccggacgt gaatctgact tctagtaaaa atacacggtt   2820

cccttgacaa agtcgagctg tttatcccag agactgcaca attttccgtt gataggcatg   2880

gaccaatgct aactggaaat cattgcaaaa agtttttttg tcgggcggag ggtgtggtgt   2940

taagataaac agtgtgcaac agaagaaatt aaaactggaa gaaattaaag ggtttttttt   3000

agacttt                                                             3007


<210>  919
<211>  158
<212>  PRT
<213>  Homo sapiens

<400>  919


Met Lys Val Ile Glu Asn Arg Ala Leu Lys Asp Glu Glu Lys Met Glu 
1               5                   10                  15      


Leu Gln Glu Ile Gln Leu Lys Glu Ala Lys His Ile Ala Glu Glu Ala 
            20                  25                  30          


Asp Arg Lys Tyr Glu Glu Val Ala Arg Lys Leu Val Ile Ile Glu Gly 
        35                  40                  45              


Asp Leu Glu Arg Thr Glu Glu Arg Ala Glu Leu Ala Glu Ser Arg Cys 
    50                  55                  60                  


Arg Glu Met Asp Glu Gln Ile Arg Leu Met Asp Gln Asn Leu Lys Cys 
65                  70                  75                  80  


Leu Ser Ala Ala Glu Glu Lys Tyr Ser Gln Lys Glu Asp Lys Tyr Glu 
                85                  90                  95      


Glu Glu Ile Lys Ile Leu Thr Asp Lys Leu Lys Glu Ala Glu Thr Arg 
            100                 105                 110         


Ala Glu Phe Ala Glu Arg Ser Val Ala Lys Leu Glu Lys Thr Ile Asp 
        115                 120                 125             


Asp Leu Glu Asp Lys Leu Lys Cys Thr Lys Glu Glu His Leu Cys Thr 
    130                 135                 140                 


Gln Arg Met Leu Asp Gln Thr Leu Leu Asp Leu Asn Glu Met 
145                 150                 155             

<210>  920
<211>  2372
<212>  DNA
<213>  Homo sapiens

<400>  920
ggcggaagta agggtgagag gaggctgcaa cgccgagcgg aggaggcagg aaccctgctg     60

ctgctcctcc ctctgaccca gactccgcct gaggccagcc tgcgggaagc tgacctttaa    120

ctgagggctg atctttaact ggaaggctgc tttctccttt caccaccccc tccttccctg    180

tgtctttttc gccaaactgt ctctgcctct tcccggagaa tccagctggg ctagaggctg    240

agcacctttg gaaacaacat ttaagggaat gtgagcacaa tgcataatgt ctttaaaaag    300

catgttgtga tgtacacatt ttgtaattac cttttttgtt gttttgtagc aaccatttgt    360

aaaacattcc aaataattcc acagtcctga agcagcaatc gaatcccttt ctcacttttg    420

gaaggtgact tttcacctta atgcatattc ccctctccat agaggagagg aaaaggtgta    480

ggcctgcctt accgagagcc aaacagagcc cagggagact ccgctgtggg aaacctcatt    540

gttctgtaca aagtactagc taaaccagaa aggtgattcc aggaggagtt agccaaacaa    600

caacaaaaac aaaaaatgtg ctgttcaagt tttcagcttt aagatatctt tggataatgt    660

tatttctatt ttttattttt ttcattagaa gttaccaaat taagatggta agacctctga    720

gaccaaaatt ttgtcccatc tctaccccct cacaactgct tacagaatgg atcatgtccc    780

ccttatgttg aggtgaccac ttaattgctt tcctgcctcc ttgaaagaaa gaaagaaaga    840

agactgtgtt tttgccactg atttagccat gtgaaactca tctcattacc cttttctggg    900

tttgaagctg ctgtctctag aagtgccatc tcaattgtgc tttgtatcag tcagtgctgg    960

agaaatcttg aatagcttat gtacaaaact ttttaaattt tatattattt tgaaactttg   1020

ctttgggttt gtggcaccct ggccacccca tctggctgtg acagcctctg cagtccgtgg   1080

gctggcagtt tgttgatctt ttaagtttcc ttccctaccc agtccccatt ttctggtaag   1140

gtttctagga ggtctgttag gtgtacatcc tgcagcttat tggcttaaaa tgtactctcc   1200

ttttatgtgg tctctttggg gccgattggg agaaagagaa atcaatagtg caactgtttt   1260

gatactgaat attgacaagt gtctttttga aataaagaac cagtccctcc aaccctcaga   1320

cctatttgac ttttatttat taaaactaaa tgtgctttct ccacagaagc tatgaggttt   1380

gggttaaaaa tagcatcttt gtgggtggta gcaacaggat ttattcttta ttattattat   1440

ttttgagatg aagtttcatt cttgttgcct gggctggagc gtaatggctc gatctcggct   1500

cactgcaacc tccgcctcct ggttcaagag attctcctgc ctcagcctcc cgagtagctg   1560

ggattacagg cacctgccac catgcccggg taatttttta tattttaagt agagacaggg   1620

cttcaccatg ttggccaggc tggtctcgaa ctcctgacct tcaggtgatc cacctgcctc   1680

agcttcccaa aatgctggga ttacgggcgt gagccaccgc acccagctgg agcaacagga   1740

tttaatatag agcaaatgtt tagttttatc atctgtaaaa tggagataag tattgtcaga   1800

gtaaacatga agattagaaa gaacacttaa tgtgctgggc cttttatagg ttaacactga   1860

catctcaggc tgaactatat acattttcct tcacaaccat atcaatcctt ataaactatg   1920

gatttatgct ccttaaaaca atatataatg ctgatcacta ctataaatgc gtggttttaa   1980

ccaactgtac tgaaacagct ttgagtttat attctgtttg gatatttgga gaaaacaaca   2040

agtgctctca agagtatttg cttagaggcc ggctgtgtga gtggataact ttgaaagctg   2100

cttttgagac gccagtgtct ggcatttcct gcattctggc ctggaggccg gacgtgaatc   2160

tgacttctag taaaaataca cggttccctt gacaaagtcg agctgtttat cccagagact   2220

gcacaatttt ccgttgatag gcatggacca atgctaactg gaaatcattg caaaaagttt   2280

ttttgtcggg cggagggtgt ggtgttaaga taaacagtgt gcaacagaag aaattaaaac   2340

tggaagaaat taaagggttt tttttagact tt                                 2372


<210>  921
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  921


Met Cys Trp Ala Phe Tyr Arg Leu Thr Leu Thr Ser Gln Ala Glu Leu 
1               5                   10                  15      


Tyr Thr Phe Ser Phe Thr Thr Ile Ser Ile Leu Ile Asn Tyr Gly Phe 
            20                  25                  30          


Met Leu Leu Lys Thr Ile Tyr Asn Ala Asp His Tyr Tyr Lys Cys Val 
        35                  40                  45              


Val Leu Thr Asn Cys Thr Glu Thr Ala Leu Ser Leu Tyr Ser Val Trp 
    50                  55                  60                  


Ile Phe Gly Glu Asn Asn Lys Cys Ser Gln Glu Tyr Leu Leu Arg Gly 
65                  70                  75                  80  


Arg Leu Cys Glu Trp Ile Thr Leu Lys Ala Ala Phe Glu Thr Pro Val 
                85                  90                  95      


Ser Gly Ile Ser Cys Ile Leu Ala Trp Arg Pro Asp Val Asn Leu Thr 
            100                 105                 110         


Ser Ser Lys Asn Thr Arg Phe Pro 
        115                 120 

<210>  922
<211>  2308
<212>  DNA
<213>  Homo sapiens

<400>  922
gcgtagcagg cggaagtaag ggtgagagga ggctgcaacg ccgagcggag gaggcaggaa     60

ccggagcgcg agcagtagct gggtgggcac catggctggg atcaccacca tcgaggcggt    120

gaagcgcaag atccaggttc tgcagcagca ggcagatgat gcagaggagc gagctgagca    180

cctttggaaa caacatttaa gggaatgtga gcacaatgca taatgtcttt aaaaagcatg    240

ttgtgatgta cacattttgt aattaccttt tttgttgttt tgtagcaacc atttgtaaaa    300

cattccaaat aattccacag tcctgaagca gcaatcgaat ccctttctca cttttggaag    360

gtgacttttc accttaatgc atattcccct ctccatagag gagaggaaaa ggtgtaggcc    420

tgccttaccg agagccaaac agagcccagg gagactccgc tgtgggaaac ctcattgttc    480

tgtacaaagt actagctaaa ccagaaaggt gattccagga ggagttagcc aaacaacaac    540

aaaaacaaaa aatgtgctgt tcaagttttc agctttaaga tatctttgga taatgttatt    600

tctatttttt atttttttca ttagaagtta ccaaattaag atggtaagac ctctgagacc    660

aaaattttgt cccatctcta ccccctcaca actgcttaca gaatggatca tgtccccctt    720

atgttgaggt gaccacttaa ttgctttcct gcctccttga aagaaagaaa gaaagaagac    780

tgtgtttttg ccactgattt agccatgtga aactcatctc attacccttt tctgggtttg    840

aagctgctgt ctctagaagt gccatctcaa ttgtgctttg tatcagtcag tgctggagaa    900

atcttgaata gcttatgtac aaaacttttt aaattttata ttattttgaa actttgcttt    960

gggtttgtgg caccctggcc accccatctg gctgtgacag cctctgcagt ccgtgggctg   1020

gcagtttgtt gatcttttaa gtttccttcc ctacccagtc cccattttct ggtaaggttt   1080

ctaggaggtc tgttaggtgt acatcctgca gcttattggc ttaaaatgta ctctcctttt   1140

atgtggtctc tttggggccg attgggagaa agagaaatca atagtgcaac tgttttgata   1200

ctgaatattg acaagtgtct ttttgaaata aagaaccagt ccctccaacc ctcagaccta   1260

tttgactttt atttattaaa actaaatgtg ctttctccac agaagctatg aggtttgggt   1320

taaaaatagc atctttgtgg gtggtagcaa caggatttat tctttattat tattattttt   1380

gagatgaagt ttcattcttg ttgcctgggc tggagcgtaa tggctcgatc tcggctcact   1440

gcaacctccg cctcctggtt caagagattc tcctgcctca gcctcccgag tagctgggat   1500

tacaggcacc tgccaccatg cccgggtaat tttttatatt ttaagtagag acagggcttc   1560

accatgttgg ccaggctggt ctcgaactcc tgaccttcag gtgatccacc tgcctcagct   1620

tcccaaaatg ctgggattac gggcgtgagc caccgcaccc agctggagca acaggattta   1680

atatagagca aatgtttagt tttatcatct gtaaaatgga gataagtatt gtcagagtaa   1740

acatgaagat tagaaagaac acttaatgtg ctgggccttt tataggttaa cactgacatc   1800

tcaggctgaa ctatatacat tttccttcac aaccatatca atccttataa actatggatt   1860

tatgctcctt aaaacaatat ataatgctga tcactactat aaatgcgtgg ttttaaccaa   1920

ctgtactgaa acagctttga gtttatattc tgtttggata tttggagaaa acaacaagtg   1980

ctctcaagag tatttgctta gaggccggct gtgtgagtgg ataactttga aagctgcttt   2040

tgagacgcca gtgtctggca tttcctgcat tctggcctgg aggccggacg tgaatctgac   2100

ttctagtaaa aatacacggt tcccttgaca aagtcgagct gtttatccca gagactgcac   2160

aattttccgt tgataggcat ggaccaatgc taactggaaa tcattgcaaa aagttttttt   2220

gtcgggcgga gggtgtggtg ttaagataaa cagtgtgcaa cagaagaaat taaaactgga   2280

agaaattaaa gggttttttt tagacttt                                      2308


<210>  923
<211>  43
<212>  PRT
<213>  Homo sapiens

<400>  923


Met Ala Gly Ile Thr Thr Ile Glu Ala Val Lys Arg Lys Ile Gln Val 
1               5                   10                  15      


Leu Gln Gln Gln Ala Asp Asp Ala Glu Glu Arg Ala Glu His Leu Trp 
            20                  25                  30          


Lys Gln His Leu Arg Glu Cys Glu His Asn Ala 
        35                  40              

<210>  924
<211>  1810
<212>  DNA
<213>  Homo sapiens

<400>  924
agggcgtagc aggcggaagt aagggtgaga ggaggctgca acgccgagcg gaggaggcag     60

gaaccggagc gcgagcagta gctgggtggg caccatggct gggatcacca ccatcgaggc    120

ggtgaagcgc aagatccagg ttctgcagca gcaggcagat gatgcagagg agcgagctga    180

gcgcctccag cgagaagttg agggagaaag gcgggcccgg gaacaggctg aggctgaggt    240

ggcctccttg aaccgtagga tccagctggt tgaagaagag ctggaccgtg ctcaggagcg    300

cctggccact gccctgcaaa agctggaaga agctgaaaaa gctgctgatg agagtgagag    360

aggtatgaag gttattgaaa accgggcctt aaaagatgaa aaatcttgaa tagcttatgt    420

acaaaacttt ttaaatttta tattattttg aaactttgct ttgggtttgt ggcaccctgg    480

ccaccccatc tggctgtgac agcctctgca gtccgtgggc tggcagtttg ttgatctttt    540

aagtttcctt ccctacccag tccccatttt ctggtaaggt ttctaggagg tctgttaggt    600

gtacatcctg cagcttattg gcttaaaatg tactctcctt ttatgtggtc tctttggggc    660

cgattgggag aaagagaaat caatagtgca actgttttga tactgaatat tgacaagtgt    720

ctttttgaaa taaagaacca gtccctccaa ccctcagacc tatttgactt ttatttatta    780

aaactaaatg tgctttctcc acagaagcta tgaggtttgg gttaaaaata gcatctttgt    840

gggtggtagc aacaggattt attctttatt attattattt ttgagatgaa gtttcattct    900

tgttgcctgg gctggagcgt aatggctcga tctcggctca ctgcaacctc cgcctcctgg    960

ttcaagagat tctcctgcct cagcctcccg agtagctggg attacaggca cctgccacca   1020

tgcccgggta attttttata ttttaagtag agacagggct tcaccatgtt ggccaggctg   1080

gtctcgaact cctgaccttc aggtgatcca cctgcctcag cttcccaaaa tgctgggatt   1140

acgggcgtga gccaccgcac ccagctggag caacaggatt taatatagag caaatgttta   1200

gttttatcat ctgtaaaatg gagataagta ttgtcagagt aaacatgaag attagaaaga   1260

acacttaatg tgctgggcct tttataggtt aacactgaca tctcaggctg aactatatac   1320

attttccttc acaaccatat caatccttat aaactatgga tttatgctcc ttaaaacaat   1380

atataatgct gatcactact ataaatgcgt ggttttaacc aactgtactg aaacagcttt   1440

gagtttatat tctgtttgga tatttggaga aaacaacaag tgctctcaag agtatttgct   1500

tagaggccgg ctgtgtgagt ggataacttt gaaagctgct tttgagacgc cagtgtctgg   1560

catttcctgc attctggcct ggaggccgga cgtgaatctg acttctagta aaaatacacg   1620

gttcccttga caaagtcgag ctgtttatcc cagagactgc acaattttcc gttgataggc   1680

atggaccaat gctaactgga aatcattgca aaaagttttt ttgtcgggcg gagggtgtgg   1740

tgttaagata aacagtgtgc aacagaagaa attaaaactg gaagaaatta aagggttttt   1800

tttagacttt                                                          1810


<210>  925
<211>  104
<212>  PRT
<213>  Homo sapiens

<400>  925


Met Ala Gly Ile Thr Thr Ile Glu Ala Val Lys Arg Lys Ile Gln Val 
1               5                   10                  15      


Leu Gln Gln Gln Ala Asp Asp Ala Glu Glu Arg Ala Glu Arg Leu Gln 
            20                  25                  30          


Arg Glu Val Glu Gly Glu Arg Arg Ala Arg Glu Gln Ala Glu Ala Glu 
        35                  40                  45              


Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu Glu Glu Leu Asp 
    50                  55                  60                  


Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys Leu Glu Glu Ala 
65                  70                  75                  80  


Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys Val Ile Glu Asn 
                85                  90                  95      


Arg Ala Leu Lys Asp Glu Lys Ser 
            100                 

<210>  926
<211>  5162
<212>  DNA
<213>  Homo sapiens

<400>  926
agggcgtagc aggcggaagt aagggtgaga ggaggctgca acgccgagcg gaggaggcag     60

gaaccggagc gcgagcagta gctgggtggg caccatggct gggatcacca ccatcgaggc    120

ggtgaagcgc aagatccagg ttctgcagca gcaggcagat gatgcagagg agcgagctga    180

gcgcctccag cgagaagttg agggagaaag gcgggcccgg gaacagaggt atgaaggtta    240

ttgaaaaccg ggccttaaaa gatgaagaaa agatggaact ccaggaaatc caactcaaag    300

aagctaagca cattgcagaa gaggcagata ggaagtatga agaggtggct cgtaagttgg    360

tgatcattga aggagacttg gaacgcacag aggaacgagc tgagctggca gagtcgtgag    420

tatctagctc cccaaatctt gtcattacca atttatccct tcccctttgg cttgggcact    480

aatatgaata aattagcatt ccttcaacct tgttaaacag ggcctaggga atgggagtca    540

tctatagtgc ttttttaggc ccaagaatgg ttttaggctt ccttattctc ctgactagtg    600

acaagtgaca aaagaggctt tcttattttt tgttggtagg gtttacaaat tgagagcaaa    660

taaggactaa tacatggtga acagttaatt ggaagatcct actgggtcct tccacctggg    720

gtggaagaca tcaaagtggc tatcctgatt taagatctag tgtctggctg ggtgtggtgg    780

ctcaaacctg tagtcccagc tacttagtat gccaaggcag gaaggttgct tgaacccagg    840

agttggaggc cagcctgggc gtcataggga gaccctgtcc ctaaaacaaa taaatttaaa    900

aaaaaaatct ggtgtctgtt ttggccactt tgccaatctg ctagggaacc ttagggcaag    960

ggtagatatt aactgctctc ccgtcggtac cttctgggcc ttgattaaca aagtcagtgc   1020

tgaatgcata tgtatttgtg cttccctctt acattcccgt ctgccagaca taacatatca   1080

tgaccatggt ggtgttctct tcccattttt tgaatttttt tttttcgttt tgctgcttgt   1140

tttcttgctg tgttcctttt tgacctttct ccctccccac aacctggctt gtgccatccc   1200

cgtgactatc actaacagcc gttgccgaga gatggatgag cagattagac tgatggacca   1260

gaacctgaag tgtctgagtg ctgctgaaga aaaggtacta accattaagc ccacagcaag   1320

gttatatatg tggtgtggtt ttgttttgtt ttgtttttgt tttgcagctg cctcccctcc   1380

acttgatttt gttgagtgct gtctcatctc ttcatggaat gctccattct tttccactta   1440

cttggcatct ttcatctctt ctttcctagt tgcttcactg cctctccaca gggtctcctt   1500

cctttgggtg atttggggga ctgtttgggt tgggcatttg ttcccacctc caccccaggt   1560

agcagttatg acttgttcct ggtagtggat ttctctcaag tgctttatta gtattcaaac   1620

atttttgagc ccaggaaggt ctagctcctg acacgttcta tggtagaggg aggagggttg   1680

atgcttgctc aggttacttg ggaacatctc ttccccagta tgccttccaa ctctctctac   1740

atataggttc aattcacgtc tatgtgtctc tctccctttt tttattctct tccttttccc   1800

ttttcctctc ctgtggtatt taaaatattc acagtaagtg ttctgagctg gaggaggagc   1860

tgaagaatgt caccaacaac ctcaagtctc ttgaggctca ggcggagaag gtaggggctg   1920

gtttgtgaaa gtgacaggct ttggggcctg ggcccagccc tgcccttgat gaaagactgg   1980

agacacgcat tccatatata atccagtgag gcgtgtcctc ttcctacctc cttaccatgt   2040

attcaggttc tgggtttaat gctattttct gtgcactttg attgctttaa ttaaaataac   2100

ttcttggtct caggttactg gagtcatgtg ctccttaggc tgatactgct gtgctgaaaa   2160

gcaataatca agggccctaa caggctttct agcagacaga tgggggcaac agacagaatc   2220

agctctgaga cctaatgagc aatcaagaca gatgacttca ctttgccatc atgtgggtgt   2280

gtttcagtca tgtgaccttg gggtgctact actcttgctc atcaagcagg ggaaaggaaa   2340

aacacctcct tgggttgatc tgaataatat caaagcttag atccatctta aaaagtcatg   2400

gagaatttta acctgaggat ctcatggctc taaagacata gatttctgaa tttcaaggac   2460

ctattgtcca gagccaggcc ttgctcttac tcttggacca ttcagcacat ttagtgcaag   2520

aggatattca atgtaagtta aatgtaggga ggggggtatt gcctgtgtga ctaatttcta   2580

ctctgaaatt tttaatctac ttatcttaca gtactctcaa aaagaagata aatatgagga   2640

agaaatcaag attcttactg ataaactcaa ggaggcagag acccgtgctg agtttgctga   2700

gagatcggta gccaagctgg aaaagacaat tgatgacctg gaagataaac tgaaatgcac   2760

caaagaggag cacctctgta cacaaaggat gctggaccag accctgcttg acctgaatga   2820

gatgtagaac gccccagtcc caccctgctg ctgctcctcc ctctgaccca gactccgcct   2880

gaggccagcc tgcgggaagc tgacctttaa ctgagggctg atctttaact ggaaggctgc   2940

tttctccttt caccaccccc tccttccctg tgtctttttc gccaaactgt ctctgcctct   3000

tcccggagaa tccagctggg ctagaggctg agcacctttg gaaacaacat ttaagggaat   3060

gtgagcacaa tgcataatgt ctttaaaaag catgttgtga tgtacacatt ttgtaattac   3120

cttttttgtt gttttgtagc aaccatttgt aaaacattcc aaataattcc acagtcctga   3180

agcagcaatc gaatcccttt ctcacttttg gaaggtgact tttcacctta atgcatattc   3240

ccctctccat agaggagagg aaaaggtgta ggcctgcctt accgagagcc aaacagagcc   3300

cagggagact ccgctgtggg aaacctcatt gttctgtaca aagtactagc taaaccagaa   3360

aggtgattcc aggaggagtt agccaaacaa caacaaaaac aaaaaatgtg ctgttcaagt   3420

tttcagcttt aagatatctt tggataatgt tatttctatt ttttattttt ttcattagaa   3480

gttaccaaat taagatggta agacctctga gaccaaaatt ttgtcccatc tctaccccct   3540

cacaactgct tacagaatgg atcatgtccc ccttatgttg aggtgaccac ttaattgctt   3600

tcctgcctcc ttgaaagaaa gaaagaaaga agactgtgtt tttgccactg atttagccat   3660

gtgaaactca tctcattacc cttttctggg tttgaagctg ctgtctctag aagtgccatc   3720

tcaattgtgc tttgtatcag tcagtgctgg agaaatcttg aatagcttat gtacaaaact   3780

ttttaaattt tatattattt tgaaactttg ctttgggttt gtggcaccct ggccacccca   3840

tctggctgtg acagcctctg cagtccgtgg gctggcagtt tgttgatctt ttaagtttcc   3900

ttccctaccc agtccccatt ttctggtaag gtttctagga ggtctgttag gtgtacatcc   3960

tgcagcttat tggcttaaaa tgtactctcc ttttatgtgg tctctttggg gccgattggg   4020

agaaagagaa atcaatagtg caactgtttt gatactgaat attgacaagt gtctttttga   4080

aataaagaac cagtccctcc aaccctcaga cctatttgac ttttatttat taaaactaaa   4140

tgtgctttct ccacagaagc tatgaggttt gggttaaaaa tagcatcttt gtgggtggta   4200

gcaacaggat ttattcttta ttattattat ttttgagatg aagtttcatt cttgttgcct   4260

gggctggagc gtaatggctc gatctcggct cactgcaacc tccgcctcct ggttcaagag   4320

attctcctgc ctcagcctcc cgagtagctg ggattacagg cacctgccac catgcccggg   4380

taatttttta tattttaagt agagacaggg cttcaccatg ttggccaggc tggtctcgaa   4440

ctcctgacct tcaggtgatc cacctgcctc agcttcccaa aatgctggga ttacgggcgt   4500

gagccaccgc acccagctgg agcaacagga tttaatatag agcaaatgtt tagttttatc   4560

atctgtaaaa tggagataag tattgtcaga gtaaacatga agattagaaa gaacacttaa   4620

tgtgctgggc cttttatagg ttaacactga catctcaggc tgaactatat acattttcct   4680

tcacaaccat atcaatcctt ataaactatg gatttatgct ccttaaaaca atatataatg   4740

ctgatcacta ctataaatgc gtggttttaa ccaactgtac tgaaacagct ttgagtttat   4800

attctgtttg gatatttgga gaaaacaaca agtgctctca agagtatttg cttagaggcc   4860

ggctgtgtga gtggataact ttgaaagctg cttttgagac gccagtgtct ggcatttcct   4920

gcattctggc ctggaggccg gacgtgaatc tgacttctag taaaaataca cggttccctt   4980

gacaaagtcg agctgtttat cccagagact gcacaatttt ccgttgatag gcatggacca   5040

atgctaactg gaaatcattg caaaaagttt ttttgtcggg cggagggtgt ggtgttaaga   5100

taaacagtgt gcaacagaag aaattaaaac tggaagaaat taaagggttt tttttagact   5160

tt                                                                  5162


<210>  927
<211>  86
<212>  PRT
<213>  Homo sapiens

<400>  927


Met Met Gln Arg Ser Glu Leu Ser Ala Ser Ser Glu Lys Leu Arg Glu 
1               5                   10                  15      


Lys Gly Gly Pro Gly Asn Arg Gly Met Lys Val Ile Glu Asn Arg Ala 
            20                  25                  30          


Leu Lys Asp Glu Glu Lys Met Glu Leu Gln Glu Ile Gln Leu Lys Glu 
        35                  40                  45              


Ala Lys His Ile Ala Glu Glu Ala Asp Arg Lys Tyr Glu Glu Val Ala 
    50                  55                  60                  


Arg Lys Leu Val Ile Ile Glu Gly Asp Leu Glu Arg Thr Glu Glu Arg 
65                  70                  75                  80  


Ala Glu Leu Ala Glu Ser 
                85      

<210>  928
<211>  2701
<212>  DNA
<213>  Homo sapiens

<400>  928
agggcgtagc aggcggaagt aagggtgaga ggaggctgca acgccgagcg gaggaggcag     60

gaaccggagc gcgagcagta gctgggtggg caccatggct gggatcacca ccatcgaggc    120

ggtgaagcgc aagatccagg ttctgcagca gcaggcagat gatgcagagg agcgagctga    180

gcgcctccag cgagaagttg agggagaaag gcgggcccgg gaacaggctg aggctgaggt    240

ggcctccttg aaccgtagga tccagctggt tgaagaagag ctggaccgtg ctcaggagcg    300

cctggccact gccctgcaaa agctggaaga agctgaaaaa gctgctgatg agagtgagag    360

atgtagaacg ccccagtccc accctgctgc tgctcctccc tctgacccag actccgcctg    420

aggccagcct gcgggaagct gacctttaac tgagggctga tctttaactg gaaggctgct    480

ttctcctttc accaccccct ccttccctgt gtctttttcg ccaaactgtc tctgcctctt    540

cccggagaat ccagctgggc tagaggctga gcacctttgg aaacaacatt taagggaatg    600

tgagcacaat gcataatgtc tttaaaaagc atgttgtgat gtacacattt tgtaattacc    660

ttttttgttg ttttgtagca accatttgta aaacattcca aataattcca cagtcctgaa    720

gcagcaatcg aatccctttc tcacttttgg aaggtgactt ttcaccttaa tgcatattcc    780

cctctccata gaggagagga aaaggtgtag gcctgcctta ccgagagcca aacagagccc    840

agggagactc cgctgtggga aacctcattg ttctgtacaa agtactagct aaaccagaaa    900

ggtgattcca ggaggagtta gccaaacaac aacaaaaaca aaaaatgtgc tgttcaagtt    960

ttcagcttta agatatcttt ggataatgtt atttctattt tttatttttt tcattagaag   1020

ttaccaaatt aagatggtaa gacctctgag accaaaattt tgtcccatct ctaccccctc   1080

acaactgctt acagaatgga tcatgtcccc cttatgttga ggtgaccact taattgcttt   1140

cctgcctcct tgaaagaaag aaagaaagaa gactgtgttt ttgccactga tttagccatg   1200

tgaaactcat ctcattaccc ttttctgggt ttgaagctgc tgtctctaga agtgccatct   1260

caattgtgct ttgtatcagt cagtgctgga gaaatcttga atagcttatg tacaaaactt   1320

tttaaatttt atattatttt gaaactttgc tttgggtttg tggcaccctg gccaccccat   1380

ctggctgtga cagcctctgc agtccgtggg ctggcagttt gttgatcttt taagtttcct   1440

tccctaccca gtccccattt tctggtaagg tttctaggag gtctgttagg tgtacatcct   1500

gcagcttatt ggcttaaaat gtactctcct tttatgtggt ctctttgggg ccgattggga   1560

gaaagagaaa tcaatagtgc aactgttttg atactgaata ttgacaagtg tctttttgaa   1620

ataaagaacc agtccctcca accctcagac ctatttgact tttatttatt aaaactaaat   1680

gtgctttctc cacagaagct atgaggtttg ggttaaaaat agcatctttg tgggtggtag   1740

caacaggatt tattctttat tattattatt tttgagatga agtttcattc ttgttgcctg   1800

ggctggagcg taatggctcg atctcggctc actgcaacct ccgcctcctg gttcaagaga   1860

ttctcctgcc tcagcctccc gagtagctgg gattacaggc acctgccacc atgcccgggt   1920

aattttttat attttaagta gagacagggc ttcaccatgt tggccaggct ggtctcgaac   1980

tcctgacctt caggtgatcc acctgcctca gcttcccaaa atgctgggat tacgggcgtg   2040

agccaccgca cccagctgga gcaacaggat ttaatataga gcaaatgttt agttttatca   2100

tctgtaaaat ggagataagt attgtcagag taaacatgaa gattagaaag aacacttaat   2160

gtgctgggcc ttttataggt taacactgac atctcaggct gaactatata cattttcctt   2220

cacaaccata tcaatcctta taaactatgg atttatgctc cttaaaacaa tatataatgc   2280

tgatcactac tataaatgcg tggttttaac caactgtact gaaacagctt tgagtttata   2340

ttctgtttgg atatttggag aaaacaacaa gtgctctcaa gagtatttgc ttagaggccg   2400

gctgtgtgag tggataactt tgaaagctgc ttttgagacg ccagtgtctg gcatttcctg   2460

cattctggcc tggaggccgg acgtgaatct gacttctagt aaaaatacac ggttcccttg   2520

acaaagtcga gctgtttatc ccagagactg cacaattttc cgttgatagg catggaccaa   2580

tgctaactgg aaatcattgc aaaaagtttt tttgtcgggc ggagggtgtg gtgttaagat   2640

aaacagtgtg caacagaaga aattaaaact ggaagaaatt aaagggtttt ttttagactt   2700

t                                                                   2701


<210>  929
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  929


Met Ala Gly Ile Thr Thr Ile Glu Ala Val Lys Arg Lys Ile Gln Val 
1               5                   10                  15      


Leu Gln Gln Gln Ala Asp Asp Ala Glu Glu Arg Ala Glu Arg Leu Gln 
            20                  25                  30          


Arg Glu Val Glu Gly Glu Arg Arg Ala Arg Glu Gln Ala Glu Ala Glu 
        35                  40                  45              


Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu Glu Glu Leu Asp 
    50                  55                  60                  


Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys Leu Glu Glu Ala 
65                  70                  75                  80  


Glu Lys Ala Ala Asp Glu Ser Glu Arg Cys Arg Thr Pro Gln Ser His 
                85                  90                  95      


Pro Ala Ala Ala Pro Pro Ser Asp Pro Asp Ser Ala 
            100                 105             

<210>  930
<211>  3106
<212>  DNA
<213>  Homo sapiens

<400>  930
agggcgtagc aggcggaagt aagggtgaga ggaggctgca acgccgagcg gaggaggcag     60

gaaccggagc gcgagcagta gctgggtggg caccatggct gggatcacca ccatcgaggc    120

ggtgaagcgc aagatccagg ttctgcagca gcaggcagat gatgcagagg agcgagctga    180

gcgcctccag cgagaagttg agggagaaag gcgggcccgg gaacaggctg aggctgaggt    240

ggcctccttg aaccgtagga tccagctggt tgaagaagag ctggaccgtg ctcaggagcg    300

cctggccact gccctgcaaa agctggaaga aaaaagatgg aactccagga aatccaactc    360

aaagaagcta agcacattgc agaagaggca gataggaagt atgaagaggt ggctcgtaag    420

ttggtgatca ttgaaggaga cttggaacgc acagaggaac gagctgagct ggcagagtcc    480

cgttgccgag agatggatga gcagattaga ctgatggacc agaacctgaa gtgtctgagt    540

gctgctgaag aaaagtactc tcaaaaagaa gataaatatg aggaagaaat caagattctt    600

actgataaac tcaaggaggc agagacccgt gctgagtttg ctgagagatc ggtagccaag    660

ctggaaaaga caattgatga cctggaagat aaactgaaat gcaccaaaga ggagcacctc    720

tgtacacaaa ggatgctgga ccagaccctg cttgacctga atgagatgta gaacgcccca    780

gtcccaccct gctgctgctc ctccctctga cccagactcc gcctgaggcc agcctgcggg    840

aagctgacct ttaactgagg gctgatcttt aactggaagg ctgctttctc ctttcaccac    900

cccctccttc cctgtgtctt tttcgccaaa ctgtctctgc ctcttcccgg agaatccagc    960

tgggctagag gctgagcacc tttggaaaca acatttaagg gaatgtgagc acaatgcata   1020

atgtctttaa aaagcatgtt gtgatgtaca cattttgtaa ttaccttttt tgttgttttg   1080

tagcaaccat ttgtaaaaca ttccaaataa ttccacagtc ctgaagcagc aatcgaatcc   1140

ctttctcact tttggaaggt gacttttcac cttaatgcat attcccctct ccatagagga   1200

gaggaaaagg tgtaggcctg ccttaccgag agccaaacag agcccaggga gactccgctg   1260

tgggaaacct cattgttctg tacaaagtac tagctaaacc agaaaggtga ttccaggagg   1320

agttagccaa acaacaacaa aaacaaaaaa tgtgctgttc aagttttcag ctttaagata   1380

tctttggata atgttatttc tattttttat ttttttcatt agaagttacc aaattaagat   1440

ggtaagacct ctgagaccaa aattttgtcc catctctacc ccctcacaac tgcttacaga   1500

atggatcatg tcccccttat gttgaggtga ccacttaatt gctttcctgc ctccttgaaa   1560

gaaagaaaga aagaagactg tgtttttgcc actgatttag ccatgtgaaa ctcatctcat   1620

tacccttttc tgggtttgaa gctgctgtct ctagaagtgc catctcaatt gtgctttgta   1680

tcagtcagtg ctggagaaat cttgaatagc ttatgtacaa aactttttaa attttatatt   1740

attttgaaac tttgctttgg gtttgtggca ccctggccac cccatctggc tgtgacagcc   1800

tctgcagtcc gtgggctggc agtttgttga tcttttaagt ttccttccct acccagtccc   1860

cattttctgg taaggtttct aggaggtctg ttaggtgtac atcctgcagc ttattggctt   1920

aaaatgtact ctccttttat gtggtctctt tggggccgat tgggagaaag agaaatcaat   1980

agtgcaactg ttttgatact gaatattgac aagtgtcttt ttgaaataaa gaaccagtcc   2040

ctccaaccct cagacctatt tgacttttat ttattaaaac taaatgtgct ttctccacag   2100

aagctatgag gtttgggtta aaaatagcat ctttgtgggt ggtagcaaca ggatttattc   2160

tttattatta ttatttttga gatgaagttt cattcttgtt gcctgggctg gagcgtaatg   2220

gctcgatctc ggctcactgc aacctccgcc tcctggttca agagattctc ctgcctcagc   2280

ctcccgagta gctgggatta caggcacctg ccaccatgcc cgggtaattt tttatatttt   2340

aagtagagac agggcttcac catgttggcc aggctggtct cgaactcctg accttcaggt   2400

gatccacctg cctcagcttc ccaaaatgct gggattacgg gcgtgagcca ccgcacccag   2460

ctggagcaac aggatttaat atagagcaaa tgtttagttt tatcatctgt aaaatggaga   2520

taagtattgt cagagtaaac atgaagatta gaaagaacac ttaatgtgct gggcctttta   2580

taggttaaca ctgacatctc aggctgaact atatacattt tccttcacaa ccatatcaat   2640

ccttataaac tatggattta tgctccttaa aacaatatat aatgctgatc actactataa   2700

atgcgtggtt ttaaccaact gtactgaaac agctttgagt ttatattctg tttggatatt   2760

tggagaaaac aacaagtgct ctcaagagta tttgcttaga ggccggctgt gtgagtggat   2820

aactttgaaa gctgcttttg agacgccagt gtctggcatt tcctgcattc tggcctggag   2880

gccggacgtg aatctgactt ctagtaaaaa tacacggttc ccttgacaaa gtcgagctgt   2940

ttatcccaga gactgcacaa ttttccgttg ataggcatgg accaatgcta actggaaatc   3000

attgcaaaaa gtttttttgt cgggcggagg gtgtggtgtt aagataaaca gtgtgcaaca   3060

gaagaaatta aaactggaag aaattaaagg gtttttttta gacttt                  3106


<210>  931
<211>  144
<212>  PRT
<213>  Homo sapiens

<400>  931


Met Glu Leu Gln Glu Ile Gln Leu Lys Glu Ala Lys His Ile Ala Glu 
1               5                   10                  15      


Glu Ala Asp Arg Lys Tyr Glu Glu Val Ala Arg Lys Leu Val Ile Ile 
            20                  25                  30          


Glu Gly Asp Leu Glu Arg Thr Glu Glu Arg Ala Glu Leu Ala Glu Ser 
        35                  40                  45              


Arg Cys Arg Glu Met Asp Glu Gln Ile Arg Leu Met Asp Gln Asn Leu 
    50                  55                  60                  


Lys Cys Leu Ser Ala Ala Glu Glu Lys Tyr Ser Gln Lys Glu Asp Lys 
65                  70                  75                  80  


Tyr Glu Glu Glu Ile Lys Ile Leu Thr Asp Lys Leu Lys Glu Ala Glu 
                85                  90                  95      


Thr Arg Ala Glu Phe Ala Glu Arg Ser Val Ala Lys Leu Glu Lys Thr 
            100                 105                 110         


Ile Asp Asp Leu Glu Asp Lys Leu Lys Cys Thr Lys Glu Glu His Leu 
        115                 120                 125             


Cys Thr Gln Arg Met Leu Asp Gln Thr Leu Leu Asp Leu Asn Glu Met 
    130                 135                 140                 

<210>  932
<211>  2738
<212>  DNA
<213>  Homo sapiens

<400>  932
agggcgtagc aggcggaagt aagggtgaga ggaggctgca acgccgagcg gaggaggcag     60

gaaccggagc gcgagcagta gctgggtggg caccatggct gggatcacca ccatcgaggc    120

ggtgaagcgc aagatccagg ttctgcagca gcaggcagat gatgcagagg agcgagctga    180

gcgcctccag cgagaagttg agggagaaag gcgggcccgg gaacaggctg aggctgaggt    240

ggcctccttg aaccgtagga tccagctggt tgaagaagag ctggaccgtg ctcaggagcg    300

cctggccact gccctgcaaa agctggaaga agctgaaaaa gctgctgatg agagtgagag    360

aggtatgaag gttattgaaa accgggcctt aaaagatgaa gaaaagatgg aactccagga    420

aatccaactc aaagaagcta agcacattgc agaagaggca gataggaagt atgaagaggt    480

ggctcgtaag ttgctgatct ttaactggaa ggctgctttc tcctttcacc accccctcct    540

tccctgtgtc tttttcgcca aactgtctct gcctcttccc ggagaatcca gctgggctag    600

aggctgagca cctttggaaa caacatttaa gggaatgtga gcacaatgca taatgtcttt    660

aaaaagcatg ttgtgatgta cacattttgt aattaccttt tttgttgttt tgtagcaacc    720

atttgtaaaa cattccaaat aattccacag tcctgaagca gcaatcgaat ccctttctca    780

cttttggaag gtgacttttc accttaatgc atattcccct ctccatagag gagaggaaaa    840

ggtgtaggcc tgccttaccg agagccaaac agagcccagg gagactccgc tgtgggaaac    900

ctcattgttc tgtacaaagt actagctaaa ccagaaaggt gattccagga ggagttagcc    960

aaacaacaac aaaaacaaaa aatgtgctgt tcaagttttc agctttaaga tatctttgga   1020

taatgttatt tctatttttt atttttttca ttagaagtta ccaaattaag atggtaagac   1080

ctctgagacc aaaattttgt cccatctcta ccccctcaca actgcttaca gaatggatca   1140

tgtccccctt atgttgaggt gaccacttaa ttgctttcct gcctccttga aagaaagaaa   1200

gaaagaagac tgtgtttttg ccactgattt agccatgtga aactcatctc attacccttt   1260

tctgggtttg aagctgctgt ctctagaagt gccatctcaa ttgtgctttg tatcagtcag   1320

tgctggagaa atcttgaata gcttatgtac aaaacttttt aaattttata ttattttgaa   1380

actttgcttt gggtttgtgg caccctggcc accccatctg gctgtgacag cctctgcagt   1440

ccgtgggctg gcagtttgtt gatcttttaa gtttccttcc ctacccagtc cccattttct   1500

ggtaaggttt ctaggaggtc tgttaggtgt acatcctgca gcttattggc ttaaaatgta   1560

ctctcctttt atgtggtctc tttggggccg attgggagaa agagaaatca atagtgcaac   1620

tgttttgata ctgaatattg acaagtgtct ttttgaaata aagaaccagt ccctccaacc   1680

ctcagaccta tttgactttt atttattaaa actaaatgtg ctttctccac agaagctatg   1740

aggtttgggt taaaaatagc atctttgtgg gtggtagcaa caggatttat tctttattat   1800

tattattttt gagatgaagt ttcattcttg ttgcctgggc tggagcgtaa tggctcgatc   1860

tcggctcact gcaacctccg cctcctggtt caagagattc tcctgcctca gcctcccgag   1920

tagctgggat tacaggcacc tgccaccatg cccgggtaat tttttatatt ttaagtagag   1980

acagggcttc accatgttgg ccaggctggt ctcgaactcc tgaccttcag gtgatccacc   2040

tgcctcagct tcccaaaatg ctgggattac gggcgtgagc caccgcaccc agctggagca   2100

acaggattta atatagagca aatgtttagt tttatcatct gtaaaatgga gataagtatt   2160

gtcagagtaa acatgaagat tagaaagaac acttaatgtg ctgggccttt tataggttaa   2220

cactgacatc tcaggctgaa ctatatacat tttccttcac aaccatatca atccttataa   2280

actatggatt tatgctcctt aaaacaatat ataatgctga tcactactat aaatgcgtgg   2340

ttttaaccaa ctgtactgaa acagctttga gtttatattc tgtttggata tttggagaaa   2400

acaacaagtg ctctcaagag tatttgctta gaggccggct gtgtgagtgg ataactttga   2460

aagctgcttt tgagacgcca gtgtctggca tttcctgcat tctggcctgg aggccggacg   2520

tgaatctgac ttctagtaaa aatacacggt tcccttgaca aagtcgagct gtttatccca   2580

gagactgcac aattttccgt tgataggcat ggaccaatgc taactggaaa tcattgcaaa   2640

aagttttttt gtcgggcgga gggtgtggtg ttaagataaa cagtgtgcaa cagaagaaat   2700

taaaactgga agaaattaaa gggttttttt tagacttt                           2738


<210>  933
<211>  170
<212>  PRT
<213>  Homo sapiens

<400>  933


Met Ala Gly Ile Thr Thr Ile Glu Ala Val Lys Arg Lys Ile Gln Val 
1               5                   10                  15      


Leu Gln Gln Gln Ala Asp Asp Ala Glu Glu Arg Ala Glu Arg Leu Gln 
            20                  25                  30          


Arg Glu Val Glu Gly Glu Arg Arg Ala Arg Glu Gln Ala Glu Ala Glu 
        35                  40                  45              


Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu Glu Glu Leu Asp 
    50                  55                  60                  


Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys Leu Glu Glu Ala 
65                  70                  75                  80  


Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys Val Ile Glu Asn 
                85                  90                  95      


Arg Ala Leu Lys Asp Glu Glu Lys Met Glu Leu Gln Glu Ile Gln Leu 
            100                 105                 110         


Lys Glu Ala Lys His Ile Ala Glu Glu Ala Asp Arg Lys Tyr Glu Glu 
        115                 120                 125             


Val Ala Arg Lys Leu Leu Ile Phe Asn Trp Lys Ala Ala Phe Ser Phe 
    130                 135                 140                 


His His Pro Leu Leu Pro Cys Val Phe Phe Ala Lys Leu Ser Leu Pro 
145                 150                 155                 160 


Leu Pro Gly Glu Ser Ser Trp Ala Arg Gly 
                165                 170 

<210>  934
<211>  2736
<212>  DNA
<213>  Homo sapiens

<400>  934
agggcgtagc aggcggaagt aagggtgaga ggaggctgca acgccgagcg gaggaggcag     60

gaaccggagc gcgagcagta gctgggtggg caccatggct gggatcacca ccatcgaggc    120

ggtgaagcgc aagatccagg ttctgcagca gcaggcagat gatgcagagg agcgagctga    180

gcgcctccag cgagaagttg agggagaaag gcgggcccgg gaacaggctg aggctgaggt    240

ggcctccttg aaccgtagga tccagctggt tgaagaagag ctggaccgtg ctcaggagcg    300

cctggccact gccctgcaaa agctggaaga agctgaaaaa gctgctgatg agagtgagag    360

aggtatgaag gttattgaaa accgggcctt aaaagatgaa gaaaagatgg aactccagga    420

aatccaactc aaagaagcta agcacattgc agaagaggca gataggaagt atgaagagct    480

ttaactgagg gctgatcttt aactggaagg ctgctttctc ctttcaccac cccctccttc    540

cctgtgtctt tttcgccaaa ctgtctctgc ctcttcccgg agaatccagc tgggctagag    600

gctgagcacc tttggaaaca acatttaagg gaatgtgagc acaatgcata atgtctttaa    660

aaagcatgtt gtgatgtaca cattttgtaa ttaccttttt tgttgttttg tagcaaccat    720

ttgtaaaaca ttccaaataa ttccacagtc ctgaagcagc aatcgaatcc ctttctcact    780

tttggaaggt gacttttcac cttaatgcat attcccctct ccatagagga gaggaaaagg    840

tgtaggcctg ccttaccgag agccaaacag agcccaggga gactccgctg tgggaaacct    900

cattgttctg tacaaagtac tagctaaacc agaaaggtga ttccaggagg agttagccaa    960

acaacaacaa aaacaaaaaa tgtgctgttc aagttttcag ctttaagata tctttggata   1020

atgttatttc tattttttat ttttttcatt agaagttacc aaattaagat ggtaagacct   1080

ctgagaccaa aattttgtcc catctctacc ccctcacaac tgcttacaga atggatcatg   1140

tcccccttat gttgaggtga ccacttaatt gctttcctgc ctccttgaaa gaaagaaaga   1200

aagaagactg tgtttttgcc actgatttag ccatgtgaaa ctcatctcat tacccttttc   1260

tgggtttgaa gctgctgtct ctagaagtgc catctcaatt gtgctttgta tcagtcagtg   1320

ctggagaaat cttgaatagc ttatgtacaa aactttttaa attttatatt attttgaaac   1380

tttgctttgg gtttgtggca ccctggccac cccatctggc tgtgacagcc tctgcagtcc   1440

gtgggctggc agtttgttga tcttttaagt ttccttccct acccagtccc cattttctgg   1500

taaggtttct aggaggtctg ttaggtgtac atcctgcagc ttattggctt aaaatgtact   1560

ctccttttat gtggtctctt tggggccgat tgggagaaag agaaatcaat agtgcaactg   1620

ttttgatact gaatattgac aagtgtcttt ttgaaataaa gaaccagtcc ctccaaccct   1680

cagacctatt tgacttttat ttattaaaac taaatgtgct ttctccacag aagctatgag   1740

gtttgggtta aaaatagcat ctttgtgggt ggtagcaaca ggatttattc tttattatta   1800

ttatttttga gatgaagttt cattcttgtt gcctgggctg gagcgtaatg gctcgatctc   1860

ggctcactgc aacctccgcc tcctggttca agagattctc ctgcctcagc ctcccgagta   1920

gctgggatta caggcacctg ccaccatgcc cgggtaattt tttatatttt aagtagagac   1980

agggcttcac catgttggcc aggctggtct cgaactcctg accttcaggt gatccacctg   2040

cctcagcttc ccaaaatgct gggattacgg gcgtgagcca ccgcacccag ctggagcaac   2100

aggatttaat atagagcaaa tgtttagttt tatcatctgt aaaatggaga taagtattgt   2160

cagagtaaac atgaagatta gaaagaacac ttaatgtgct gggcctttta taggttaaca   2220

ctgacatctc aggctgaact atatacattt tccttcacaa ccatatcaat ccttataaac   2280

tatggattta tgctccttaa aacaatatat aatgctgatc actactataa atgcgtggtt   2340

ttaaccaact gtactgaaac agctttgagt ttatattctg tttggatatt tggagaaaac   2400

aacaagtgct ctcaagagta tttgcttaga ggccggctgt gtgagtggat aactttgaaa   2460

gctgcttttg agacgccagt gtctggcatt tcctgcattc tggcctggag gccggacgtg   2520

aatctgactt ctagtaaaaa tacacggttc ccttgacaaa gtcgagctgt ttatcccaga   2580

gactgcacaa ttttccgttg ataggcatgg accaatgcta actggaaatc attgcaaaaa   2640

gtttttttgt cgggcggagg gtgtggtgtt aagataaaca gtgtgcaaca gaagaaatta   2700

aaactggaag aaattaaagg gtttttttta gacttt                             2736


<210>  935
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  935


Met Ala Gly Ile Thr Thr Ile Glu Ala Val Lys Arg Lys Ile Gln Val 
1               5                   10                  15      


Leu Gln Gln Gln Ala Asp Asp Ala Glu Glu Arg Ala Glu Arg Leu Gln 
            20                  25                  30          


Arg Glu Val Glu Gly Glu Arg Arg Ala Arg Glu Gln Ala Glu Ala Glu 
        35                  40                  45              


Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu Glu Glu Leu Asp 
    50                  55                  60                  


Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys Leu Glu Glu Ala 
65                  70                  75                  80  


Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys Val Ile Glu Asn 
                85                  90                  95      


Arg Ala Leu Lys Asp Glu Glu Lys Met Glu Leu Gln Glu Ile Gln Leu 
            100                 105                 110         


Lys Glu Ala Lys His Ile Ala Glu Glu Ala Asp Arg Lys Tyr Glu Glu 
        115                 120                 125             


Leu 
    

<210>  936
<211>  3073
<212>  DNA
<213>  Homo sapiens

<400>  936
agggcgtagc aggcggaagt aagggtgaga ggaggctgca acgccgagcg gaggaggcag     60

gaaccggagc gcgagcagta gctgggtggg caccatggct gggatcacca ccatcgaggc    120

ggtgaagcgc aagatccagg ttctgcagca gcaggcagat gatgcagagg agcgagctga    180

gcgcctccag cgagaagttg agggagaaag gcgggcccgg gaacaggctg aggctgaggt    240

ggcctccttg aaccgtagga tccagctggt tgaagaagag ctggaccgtg ctcaggagcg    300

cctggccact gccctgcaaa agctggaaga aaagctaagc acattgcaga agaggcagat    360

aggaagtatg aagaggtggc tcgtaagttg gtgatcattg aaggagactt ggaacgcaca    420

gaggaacgag ctgagctggc agagtcccgt tgccgagaga tggatgagca gattagactg    480

atggaccaga acctgaagtg tctgagtgct gctgaagaaa agtactctca aaaagaagat    540

aaatatgagg aagaaatcaa gattcttact gataaactca aggaggcaga gacccgtgct    600

gagtttgctg agagatcggt agccaagctg gaaaagacaa ttgatgacct ggaagataaa    660

ctgaaatgca ccaaagagga gcacctctgt acacaaagga tgctggacca gaccctgctt    720

gacctgaatg agatgtagaa cgccccagtc ccaccctgct gctgctcctc cctctgaccc    780

agactccgcc tgaggccagc ctgcgggaag ctgaccttta actgagggct gatctttaac    840

tggaaggctg ctttctcctt tcaccacccc ctccttccct gtgtcttttt cgccaaactg    900

tctctgcctc ttcccggaga atccagctgg gctagaggct gagcaccttt ggaaacaaca    960

tttaagggaa tgtgagcaca atgcataatg tctttaaaaa gcatgttgtg atgtacacat   1020

tttgtaatta ccttttttgt tgttttgtag caaccatttg taaaacattc caaataattc   1080

cacagtcctg aagcagcaat cgaatccctt tctcactttt ggaaggtgac ttttcacctt   1140

aatgcatatt cccctctcca tagaggagag gaaaaggtgt aggcctgcct taccgagagc   1200

caaacagagc ccagggagac tccgctgtgg gaaacctcat tgttctgtac aaagtactag   1260

ctaaaccaga aaggtgattc caggaggagt tagccaaaca acaacaaaaa caaaaaatgt   1320

gctgttcaag ttttcagctt taagatatct ttggataatg ttatttctat tttttatttt   1380

tttcattaga agttaccaaa ttaagatggt aagacctctg agaccaaaat tttgtcccat   1440

ctctaccccc tcacaactgc ttacagaatg gatcatgtcc cccttatgtt gaggtgacca   1500

cttaattgct ttcctgcctc cttgaaagaa agaaagaaag aagactgtgt ttttgccact   1560

gatttagcca tgtgaaactc atctcattac ccttttctgg gtttgaagct gctgtctcta   1620

gaagtgccat ctcaattgtg ctttgtatca gtcagtgctg gagaaatctt gaatagctta   1680

tgtacaaaac tttttaaatt ttatattatt ttgaaacttt gctttgggtt tgtggcaccc   1740

tggccacccc atctggctgt gacagcctct gcagtccgtg ggctggcagt ttgttgatct   1800

tttaagtttc cttccctacc cagtccccat tttctggtaa ggtttctagg aggtctgtta   1860

ggtgtacatc ctgcagctta ttggcttaaa atgtactctc cttttatgtg gtctctttgg   1920

ggccgattgg gagaaagaga aatcaatagt gcaactgttt tgatactgaa tattgacaag   1980

tgtctttttg aaataaagaa ccagtccctc caaccctcag acctatttga cttttattta   2040

ttaaaactaa atgtgctttc tccacagaag ctatgaggtt tgggttaaaa atagcatctt   2100

tgtgggtggt agcaacagga tttattcttt attattatta tttttgagat gaagtttcat   2160

tcttgttgcc tgggctggag cgtaatggct cgatctcggc tcactgcaac ctccgcctcc   2220

tggttcaaga gattctcctg cctcagcctc ccgagtagct gggattacag gcacctgcca   2280

ccatgcccgg gtaatttttt atattttaag tagagacagg gcttcaccat gttggccagg   2340

ctggtctcga actcctgacc ttcaggtgat ccacctgcct cagcttccca aaatgctggg   2400

attacgggcg tgagccaccg cacccagctg gagcaacagg atttaatata gagcaaatgt   2460

ttagttttat catctgtaaa atggagataa gtattgtcag agtaaacatg aagattagaa   2520

agaacactta atgtgctggg ccttttatag gttaacactg acatctcagg ctgaactata   2580

tacattttcc ttcacaacca tatcaatcct tataaactat ggatttatgc tccttaaaac   2640

aatatataat gctgatcact actataaatg cgtggtttta accaactgta ctgaaacagc   2700

tttgagttta tattctgttt ggatatttgg agaaaacaac aagtgctctc aagagtattt   2760

gcttagaggc cggctgtgtg agtggataac tttgaaagct gcttttgaga cgccagtgtc   2820

tggcatttcc tgcattctgg cctggaggcc ggacgtgaat ctgacttcta gtaaaaatac   2880

acggttccct tgacaaagtc gagctgttta tcccagagac tgcacaattt tccgttgata   2940

ggcatggacc aatgctaact ggaaatcatt gcaaaaagtt tttttgtcgg gcggagggtg   3000

tggtgttaag ataaacagtg tgcaacagaa gaaattaaaa ctggaagaaa ttaaagggtt   3060

ttttttagac ttt                                                      3073


<210>  937
<211>  99
<212>  PRT
<213>  Homo sapiens

<400>  937


Met Ala Gly Ile Thr Thr Ile Glu Ala Val Lys Arg Lys Ile Gln Val 
1               5                   10                  15      


Leu Gln Gln Gln Ala Asp Asp Ala Glu Glu Arg Ala Glu Arg Leu Gln 
            20                  25                  30          


Arg Glu Val Glu Gly Glu Arg Arg Ala Arg Glu Gln Ala Glu Ala Glu 
        35                  40                  45              


Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu Glu Glu Leu Asp 
    50                  55                  60                  


Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys Leu Glu Glu Lys 
65                  70                  75                  80  


Leu Ser Thr Leu Gln Lys Arg Gln Ile Gly Ser Met Lys Arg Trp Leu 
                85                  90                  95      


Val Ser Trp 
            

<210>  938
<211>  4503
<212>  DNA
<213>  Homo sapiens

<400>  938
agggcgtagc aggcggaagt aagggtgaga ggaggctgca acgccgagcg gaggaggcag     60

gaaccggagc gcgagcagta gctgggtggg caccatggct gggatcacca ccatcgaggc    120

ggtgaagcgc aagatccagg ttctgcagca gcaggcagat gatgcagagg agcgagctga    180

gcgcctccag cgagaagttg agggagaaag gcgggcccgg gaacaggctg aggctgaggt    240

ggcctccttg aaccgtagga tccagctggt tgaagaagag ctggaccgtg ctcaggagcg    300

cctggccact gccctgcaaa agctggaaga agctgaaaaa gctgctgatg agagtgagag    360

aggtatgaag gttattgaaa accgggcctt aaaagatgaa gaaaagatgg aactccagga    420

aatccaactc aaagaagcta agcacattgc agaagaggca gataggaagt atgaagaggt    480

ggctcgtaag ttggtgatca ttgaaggaga cttggaacgc acagaggaac gagctgagct    540

ggcagagtct aagtgttctg agctggagga ggagctgaag aatgtcacca acaacctcaa    600

gtctcttgag gctcaggcgg agaagtactc tcaaaaagaa gataaatatg aggaagaaat    660

caagattctt actgataaac tcaaggaggc agagacccgt gctgagtttg ctgagagatc    720

ggtagccaag ctggaaaaga caattgatga cctggaagag cgtctctaca gccaacttga    780

gcgaaaccgc ctgctttcta atgagctgaa gctaacgctg catgatctgt gtgactgatg    840

ggcagggctc aatgatgccc attaaactga gcttactgct cacaccactg acctggaccc    900

caacaaaaag ctgattgtct ttttaaaagt tattattttg ccctgagcaa attgcatttt    960

aattggggca gttagaatgt tgatttccta acagcattgt gaagttgacc attgtgaagt   1020

ttctgtccct ttagaagaga ttatgggtga agaagggagg ggcctgagag attatagtga   1080

gaaaacttgc gagaattttg ttttccaccc ttatttgctg ctctttcact tgggcactga   1140

ctgtaggata tgttcccttg catggatgtt tttaacaata aaaggactga cttgacaagt   1200

tgttgtaact gcttcatcgg caggcccagg aatgggtcct tctgactggg tggaaaaaag   1260

ggaagtgaaa gaaaagttgt gggatatgaa tatgggtctg tgttgccatc accttctctg   1320

agttgaagat ttgagtattt tcctcacctc tttagagcag tcagagtggt ttgcttgcta   1380

gacagattag attctcctta atgttcagct gctgattttc tttctgactt ttgcgtcctt   1440

tttctggttt tatgttaatt tcaagtaact gtcacaagct agttctgttc aatagctctg   1500

cagcaatctc aaggtttgct tacaactact tgtttcagta gtattcttgg ctttgttttc   1560

tttagagatt atttgactta actgtgagcg cccttttatt tatcccatca gttattactt   1620

tggcctctac tttttcgaaa aaacatgtag tgcatgagga tcttcctgtg ctctttataa   1680

tctgagattc tgatgtttct attgtttgca atgttcaaac tccggtgagc catttcaaga   1740

gggtattgtt atgtgggcaa aacctagaaa agtggatggc tgatggttaa ggcttgctct   1800

ttcattgact gaaagctgaa agtgttggtt gggtgtggga gggagaggaa atggctgata   1860

agggccctaa ctccctcacc caggaagtgc agcaacacct acaacttcag taggcaagcc   1920

aaaggcccta caaaactggg tgatgtaata gctcacttct gtggctgaga aggcagctgc   1980

tttatcagtc tgcagcttct ctgcaacagg agcaagtctc aaagagcggg tagaccttga   2040

aatttacttc tagttcttgt aacttctctc ctttaccccc attagataaa ctgaaatgca   2100

ccaaagagga gcacctctgt acacaaagga tgctggacca gaccctgctt gacctgaatg   2160

agatgtagaa cgccccagtc ccaccctgct gctgctcctc cctctgaccc agactccgcc   2220

tgaggccagc ctgcgggaag ctgaccttta actgagggct gatctttaac tggaaggctg   2280

ctttctcctt tcaccacccc ctccttccct gtgtcttttt cgccaaactg tctctgcctc   2340

ttcccggaga atccagctgg gctagaggct gagcaccttt ggaaacaaca tttaagggaa   2400

tgtgagcaca atgcataatg tctttaaaaa gcatgttgtg atgtacacat tttgtaatta   2460

ccttttttgt tgttttgtag caaccatttg taaaacattc caaataattc cacagtcctg   2520

aagcagcaat cgaatccctt tctcactttt ggaaggtgac ttttcacctt aatgcatatt   2580

cccctctcca tagaggagag gaaaaggtgt aggcctgcct taccgagagc caaacagagc   2640

ccagggagac tccgctgtgg gaaacctcat tgttctgtac aaagtactag ctaaaccaga   2700

aaggtgattc caggaggagt tagccaaaca acaacaaaaa caaaaaatgt gctgttcaag   2760

ttttcagctt taagatatct ttggataatg ttatttctat tttttatttt tttcattaga   2820

agttaccaaa ttaagatggt aagacctctg agaccaaaat tttgtcccat ctctaccccc   2880

tcacaactgc ttacagaatg gatcatgtcc cccttatgtt gaggtgacca cttaattgct   2940

ttcctgcctc cttgaaagaa agaaagaaag aagactgtgt ttttgccact gatttagcca   3000

tgtgaaactc atctcattac ccttttctgg gtttgaagct gctgtctcta gaagtgccat   3060

ctcaattgtg ctttgtatca gtcagtgctg gagaaatctt gaatagctta tgtacaaaac   3120

tttttaaatt ttatattatt ttgaaacttt gctttgggtt tgtggcaccc tggccacccc   3180

atctggctgt gacagcctct gcagtccgtg ggctggcagt ttgttgatct tttaagtttc   3240

cttccctacc cagtccccat tttctggtaa ggtttctagg aggtctgtta ggtgtacatc   3300

ctgcagctta ttggcttaaa atgtactctc cttttatgtg gtctctttgg ggccgattgg   3360

gagaaagaga aatcaatagt gcaactgttt tgatactgaa tattgacaag tgtctttttg   3420

aaataaagaa ccagtccctc caaccctcag acctatttga cttttattta ttaaaactaa   3480

atgtgctttc tccacagaag ctatgaggtt tgggttaaaa atagcatctt tgtgggtggt   3540

agcaacagga tttattcttt attattatta tttttgagat gaagtttcat tcttgttgcc   3600

tgggctggag cgtaatggct cgatctcggc tcactgcaac ctccgcctcc tggttcaaga   3660

gattctcctg cctcagcctc ccgagtagct gggattacag gcacctgcca ccatgcccgg   3720

gtaatttttt atattttaag tagagacagg gcttcaccat gttggccagg ctggtctcga   3780

actcctgacc ttcaggtgat ccacctgcct cagcttccca aaatgctggg attacgggcg   3840

tgagccaccg cacccagctg gagcaacagg atttaatata gagcaaatgt ttagttttat   3900

catctgtaaa atggagataa gtattgtcag agtaaacatg aagattagaa agaacactta   3960

atgtgctggg ccttttatag gttaacactg acatctcagg ctgaactata tacattttcc   4020

ttcacaacca tatcaatcct tataaactat ggatttatgc tccttaaaac aatatataat   4080

gctgatcact actataaatg cgtggtttta accaactgta ctgaaacagc tttgagttta   4140

tattctgttt ggatatttgg agaaaacaac aagtgctctc aagagtattt gcttagaggc   4200

cggctgtgtg agtggataac tttgaaagct gcttttgaga cgccagtgtc tggcatttcc   4260

tgcattctgg cctggaggcc ggacgtgaat ctgacttcta gtaaaaatac acggttccct   4320

tgacaaagtc gagctgttta tcccagagac tgcacaattt tccgttgata ggcatggacc   4380

aatgctaact ggaaatcatt gcaaaaagtt tttttgtcgg gcggagggtg tggtgttaag   4440

ataaacagtg tgcaacagaa gaaattaaaa ctggaagaaa ttaaagggtt ttttttagac   4500

ttt                                                                 4503


<210>  939
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  939


Met Ala Gly Ile Thr Thr Ile Glu Ala Val Lys Arg Lys Ile Gln Val 
1               5                   10                  15      


Leu Gln Gln Gln Ala Asp Asp Ala Glu Glu Arg Ala Glu Arg Leu Gln 
            20                  25                  30          


Arg Glu Val Glu Gly Glu Arg Arg Ala Arg Glu Gln Ala Glu Ala Glu 
        35                  40                  45              


Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu Glu Glu Leu Asp 
    50                  55                  60                  


Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys Leu Glu Glu Ala 
65                  70                  75                  80  


Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys Val Ile Glu Asn 
                85                  90                  95      


Arg Ala Leu Lys Asp Glu Glu Lys Met Glu Leu Gln Glu Ile Gln Leu 
            100                 105                 110         


Lys Glu Ala Lys His Ile Ala Glu Glu Ala Asp Arg Lys Tyr Glu Glu 
        115                 120                 125             


Val Ala Arg Lys Leu Val Ile Ile Glu Gly Asp Leu Glu Arg Thr Glu 
    130                 135                 140                 


Glu Arg Ala Glu Leu Ala Glu Ser Lys Cys Ser Glu Leu Glu Glu Glu 
145                 150                 155                 160 


Leu Lys Asn Val Thr Asn Asn Leu Lys Ser Leu Glu Ala Gln Ala Glu 
                165                 170                 175     


Lys Tyr Ser Gln Lys Glu Asp Lys Tyr Glu Glu Glu Ile Lys Ile Leu 
            180                 185                 190         


Thr Asp Lys Leu Lys Glu Ala Glu Thr Arg Ala Glu Phe Ala Glu Arg 
        195                 200                 205             


Ser Val Ala Lys Leu Glu Lys Thr Ile Asp Asp Leu Glu Glu Arg Leu 
    210                 215                 220                 


Tyr Ser Gln Leu Glu Arg Asn Arg Leu Leu Ser Asn Glu Leu Lys Leu 
225                 230                 235                 240 


Thr Leu His Asp Leu Cys Asp 
                245         

<210>  940
<211>  2390
<212>  DNA
<213>  Homo sapiens

<400>  940
agggcgtagc aggcggaagt aagggtgaga ggaggctgca acgccgagcg gaggaggcag     60

gaaccggagc gcgagcagta gctgggtggg caccatggct gggatcacca ccatcgaggc    120

ggtgaagcgc aagatccagg ttctgcagca gcaggcagat gatgcagagg agcgagctga    180

gcgccccctc cttccctgtg tctttttcgc caaactgtct ctgcctcttc ccggagaatc    240

cagctgggct agaggctgag cacctttgga aacaacattt aagggaatgt gagcacaatg    300

cataatgtct ttaaaaagca tgttgtgatg tacacatttt gtaattacct tttttgttgt    360

tttgtagcaa ccatttgtaa aacattccaa ataattccac agtcctgaag cagcaatcga    420

atccctttct cacttttgga aggtgacttt tcaccttaat gcatattccc ctctccatag    480

aggagaggaa aaggtgtagg cctgccttac cgagagccaa acagagccca gggagactcc    540

gctgtgggaa acctcattgt tctgtacaaa gtactagcta aaccagaaag gtgattccag    600

gaggagttag ccaaacaaca acaaaaacaa aaaatgtgct gttcaagttt tcagctttaa    660

gatatctttg gataatgtta tttctatttt ttattttttt cattagaagt taccaaatta    720

agatggtaag acctctgaga ccaaaatttt gtcccatctc taccccctca caactgctta    780

cagaatggat catgtccccc ttatgttgag gtgaccactt aattgctttc ctgcctcctt    840

gaaagaaaga aagaaagaag actgtgtttt tgccactgat ttagccatgt gaaactcatc    900

tcattaccct tttctgggtt tgaagctgct gtctctagaa gtgccatctc aattgtgctt    960

tgtatcagtc agtgctggag aaatcttgaa tagcttatgt acaaaacttt ttaaatttta   1020

tattattttg aaactttgct ttgggtttgt ggcaccctgg ccaccccatc tggctgtgac   1080

agcctctgca gtccgtgggc tggcagtttg ttgatctttt aagtttcctt ccctacccag   1140

tccccatttt ctggtaaggt ttctaggagg tctgttaggt gtacatcctg cagcttattg   1200

gcttaaaatg tactctcctt ttatgtggtc tctttggggc cgattgggag aaagagaaat   1260

caatagtgca actgttttga tactgaatat tgacaagtgt ctttttgaaa taaagaacca   1320

gtccctccaa ccctcagacc tatttgactt ttatttatta aaactaaatg tgctttctcc   1380

acagaagcta tgaggtttgg gttaaaaata gcatctttgt gggtggtagc aacaggattt   1440

attctttatt attattattt ttgagatgaa gtttcattct tgttgcctgg gctggagcgt   1500

aatggctcga tctcggctca ctgcaacctc cgcctcctgg ttcaagagat tctcctgcct   1560

cagcctcccg agtagctggg attacaggca cctgccacca tgcccgggta attttttata   1620

ttttaagtag agacagggct tcaccatgtt ggccaggctg gtctcgaact cctgaccttc   1680

aggtgatcca cctgcctcag cttcccaaaa tgctgggatt acgggcgtga gccaccgcac   1740

ccagctggag caacaggatt taatatagag caaatgttta gttttatcat ctgtaaaatg   1800

gagataagta ttgtcagagt aaacatgaag attagaaaga acacttaatg tgctgggcct   1860

tttataggtt aacactgaca tctcaggctg aactatatac attttccttc acaaccatat   1920

caatccttat aaactatgga tttatgctcc ttaaaacaat atataatgct gatcactact   1980

ataaatgcgt ggttttaacc aactgtactg aaacagcttt gagtttatat tctgtttgga   2040

tatttggaga aaacaacaag tgctctcaag agtatttgct tagaggccgg ctgtgtgagt   2100

ggataacttt gaaagctgct tttgagacgc cagtgtctgg catttcctgc attctggcct   2160

ggaggccgga cgtgaatctg acttctagta aaaatacacg gttcccttga caaagtcgag   2220

ctgtttatcc cagagactgc acaattttcc gttgataggc atggaccaat gctaactgga   2280

aatcattgca aaaagttttt ttgtcgggcg gagggtgtgg tgttaagata aacagtgtgc   2340

aacagaagaa attaaaactg gaagaaatta aagggttttt tttagacttt              2390


<210>  941
<211>  54
<212>  PRT
<213>  Homo sapiens

<400>  941


Met Ala Gly Ile Thr Thr Ile Glu Ala Val Lys Arg Lys Ile Gln Val 
1               5                   10                  15      


Leu Gln Gln Gln Ala Asp Asp Ala Glu Glu Arg Ala Glu Arg Pro Leu 
            20                  25                  30          


Leu Pro Cys Val Phe Phe Ala Lys Leu Ser Leu Pro Leu Pro Gly Glu 
        35                  40                  45              


Ser Ser Trp Ala Arg Gly 
    50                  

<210>  942
<211>  2481
<212>  DNA
<213>  Homo sapiens

<400>  942
agggcgtagc aggcggaagt aagggtgaga ggaggctgca acgccgagcg gaggaggcag     60

gaaccggagc gcgagcagta gctgggtggg caccatggct gggatcacca ccatcgaggc    120

ggtgaagcgc aagatccagg ttctgcagca gcaggcagat gatgcagagg agcgagctga    180

gcgcctccag cgagaagttg aggccagcct gcgggaagct gacctttaac tgagggctga    240

tctttaactg gaaggctgct ttctcctttc accaccccct ccttccctgt gtctttttcg    300

ccaaactgtc tctgcctctt cccggagaat ccagctgggc tagaggctga gcacctttgg    360

aaacaacatt taagggaatg tgagcacaat gcataatgtc tttaaaaagc atgttgtgat    420

gtacacattt tgtaattacc ttttttgttg ttttgtagca accatttgta aaacattcca    480

aataattcca cagtcctgaa gcagcaatcg aatccctttc tcacttttgg aaggtgactt    540

ttcaccttaa tgcatattcc cctctccata gaggagagga aaaggtgtag gcctgcctta    600

ccgagagcca aacagagccc agggagactc cgctgtggga aacctcattg ttctgtacaa    660

agtactagct aaaccagaaa ggtgattcca ggaggagtta gccaaacaac aacaaaaaca    720

aaaaatgtgc tgttcaagtt ttcagcttta agatatcttt ggataatgtt atttctattt    780

tttatttttt tcattagaag ttaccaaatt aagatggtaa gacctctgag accaaaattt    840

tgtcccatct ctaccccctc acaactgctt acagaatgga tcatgtcccc cttatgttga    900

ggtgaccact taattgcttt cctgcctcct tgaaagaaag aaagaaagaa gactgtgttt    960

ttgccactga tttagccatg tgaaactcat ctcattaccc ttttctgggt ttgaagctgc   1020

tgtctctaga agtgccatct caattgtgct ttgtatcagt cagtgctgga gaaatcttga   1080

atagcttatg tacaaaactt tttaaatttt atattatttt gaaactttgc tttgggtttg   1140

tggcaccctg gccaccccat ctggctgtga cagcctctgc agtccgtggg ctggcagttt   1200

gttgatcttt taagtttcct tccctaccca gtccccattt tctggtaagg tttctaggag   1260

gtctgttagg tgtacatcct gcagcttatt ggcttaaaat gtactctcct tttatgtggt   1320

ctctttgggg ccgattggga gaaagagaaa tcaatagtgc aactgttttg atactgaata   1380

ttgacaagtg tctttttgaa ataaagaacc agtccctcca accctcagac ctatttgact   1440

tttatttatt aaaactaaat gtgctttctc cacagaagct atgaggtttg ggttaaaaat   1500

agcatctttg tgggtggtag caacaggatt tattctttat tattattatt tttgagatga   1560

agtttcattc ttgttgcctg ggctggagcg taatggctcg atctcggctc actgcaacct   1620

ccgcctcctg gttcaagaga ttctcctgcc tcagcctccc gagtagctgg gattacaggc   1680

acctgccacc atgcccgggt aattttttat attttaagta gagacagggc ttcaccatgt   1740

tggccaggct ggtctcgaac tcctgacctt caggtgatcc acctgcctca gcttcccaaa   1800

atgctgggat tacgggcgtg agccaccgca cccagctgga gcaacaggat ttaatataga   1860

gcaaatgttt agttttatca tctgtaaaat ggagataagt attgtcagag taaacatgaa   1920

gattagaaag aacacttaat gtgctgggcc ttttataggt taacactgac atctcaggct   1980

gaactatata cattttcctt cacaaccata tcaatcctta taaactatgg atttatgctc   2040

cttaaaacaa tatataatgc tgatcactac tataaatgcg tggttttaac caactgtact   2100

gaaacagctt tgagtttata ttctgtttgg atatttggag aaaacaacaa gtgctctcaa   2160

gagtatttgc ttagaggccg gctgtgtgag tggataactt tgaaagctgc ttttgagacg   2220

ccagtgtctg gcatttcctg cattctggcc tggaggccgg acgtgaatct gacttctagt   2280

aaaaatacac ggttcccttg acaaagtcga gctgtttatc ccagagactg cacaattttc   2340

cgttgatagg catggaccaa tgctaactgg aaatcattgc aaaaagtttt tttgtcgggc   2400

ggagggtgtg gtgttaagat aaacagtgtg caacagaaga aattaaaact ggaagaaatt   2460

aaagggtttt ttttagactt t                                             2481


<210>  943
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  943


Met Ala Gly Ile Thr Thr Ile Glu Ala Val Lys Arg Lys Ile Gln Val 
1               5                   10                  15      


Leu Gln Gln Gln Ala Asp Asp Ala Glu Glu Arg Ala Glu Arg Leu Gln 
            20                  25                  30          


Arg Glu Val Glu Ala Ser Leu Arg Glu Ala Asp Leu 
        35                  40                  

<210>  944
<211>  2796
<212>  DNA
<213>  Homo sapiens

<400>  944
agggcgtagc aggcggaagt aagggtgaga ggaggctgca acgccgagcg gaggaggcag     60

gaaccggagc gcgagcagta gctgggtggg caccatggct gggatcacca ccatcgaggc    120

ggtgaagcgc aagatccagg ttctgcagca gcaggcagat gatgcagagg agcgagctga    180

gcgcctccag cgagaagttg agggagaaag gcgggcccgg gaacaggctg aggctgaggt    240

ggcctccttg aaccgtagga tccagctggt tgaagaagag ctggaccgtg ctcaggagcg    300

cctggccact gccctgcaaa agctggaaga agctgaaaaa gctgctgatg agagtgagag    360

aggtatgaag gttattgaaa accgggcctt aaaagatgaa gaaaagatgg aactccagga    420

aatccaactc aaagaagcta agcacattgc agaagaggca gataggaagt atgaagaggt    480

ggctcgtaag ttggtgatca ttgaaggaga cttggaacgc acagaggaac gagctgacct    540

ttaactgagg gctgatcttt aactggaagg ctgctttctc ctttcaccac cccctccttc    600

cctgtgtctt tttcgccaaa ctgtctctgc ctcttcccgg agaatccagc tgggctagag    660

gctgagcacc tttggaaaca acatttaagg gaatgtgagc acaatgcata atgtctttaa    720

aaagcatgtt gtgatgtaca cattttgtaa ttaccttttt tgttgttttg tagcaaccat    780

ttgtaaaaca ttccaaataa ttccacagtc ctgaagcagc aatcgaatcc ctttctcact    840

tttggaaggt gacttttcac cttaatgcat attcccctct ccatagagga gaggaaaagg    900

tgtaggcctg ccttaccgag agccaaacag agcccaggga gactccgctg tgggaaacct    960

cattgttctg tacaaagtac tagctaaacc agaaaggtga ttccaggagg agttagccaa   1020

acaacaacaa aaacaaaaaa tgtgctgttc aagttttcag ctttaagata tctttggata   1080

atgttatttc tattttttat ttttttcatt agaagttacc aaattaagat ggtaagacct   1140

ctgagaccaa aattttgtcc catctctacc ccctcacaac tgcttacaga atggatcatg   1200

tcccccttat gttgaggtga ccacttaatt gctttcctgc ctccttgaaa gaaagaaaga   1260

aagaagactg tgtttttgcc actgatttag ccatgtgaaa ctcatctcat tacccttttc   1320

tgggtttgaa gctgctgtct ctagaagtgc catctcaatt gtgctttgta tcagtcagtg   1380

ctggagaaat cttgaatagc ttatgtacaa aactttttaa attttatatt attttgaaac   1440

tttgctttgg gtttgtggca ccctggccac cccatctggc tgtgacagcc tctgcagtcc   1500

gtgggctggc agtttgttga tcttttaagt ttccttccct acccagtccc cattttctgg   1560

taaggtttct aggaggtctg ttaggtgtac atcctgcagc ttattggctt aaaatgtact   1620

ctccttttat gtggtctctt tggggccgat tgggagaaag agaaatcaat agtgcaactg   1680

ttttgatact gaatattgac aagtgtcttt ttgaaataaa gaaccagtcc ctccaaccct   1740

cagacctatt tgacttttat ttattaaaac taaatgtgct ttctccacag aagctatgag   1800

gtttgggtta aaaatagcat ctttgtgggt ggtagcaaca ggatttattc tttattatta   1860

ttatttttga gatgaagttt cattcttgtt gcctgggctg gagcgtaatg gctcgatctc   1920

ggctcactgc aacctccgcc tcctggttca agagattctc ctgcctcagc ctcccgagta   1980

gctgggatta caggcacctg ccaccatgcc cgggtaattt tttatatttt aagtagagac   2040

agggcttcac catgttggcc aggctggtct cgaactcctg accttcaggt gatccacctg   2100

cctcagcttc ccaaaatgct gggattacgg gcgtgagcca ccgcacccag ctggagcaac   2160

aggatttaat atagagcaaa tgtttagttt tatcatctgt aaaatggaga taagtattgt   2220

cagagtaaac atgaagatta gaaagaacac ttaatgtgct gggcctttta taggttaaca   2280

ctgacatctc aggctgaact atatacattt tccttcacaa ccatatcaat ccttataaac   2340

tatggattta tgctccttaa aacaatatat aatgctgatc actactataa atgcgtggtt   2400

ttaaccaact gtactgaaac agctttgagt ttatattctg tttggatatt tggagaaaac   2460

aacaagtgct ctcaagagta tttgcttaga ggccggctgt gtgagtggat aactttgaaa   2520

gctgcttttg agacgccagt gtctggcatt tcctgcattc tggcctggag gccggacgtg   2580

aatctgactt ctagtaaaaa tacacggttc ccttgacaaa gtcgagctgt ttatcccaga   2640

gactgcacaa ttttccgttg ataggcatgg accaatgcta actggaaatc attgcaaaaa   2700

gtttttttgt cgggcggagg gtgtggtgtt aagataaaca gtgtgcaaca gaagaaatta   2760

aaactggaag aaattaaagg gtttttttta gacttt                             2796


<210>  945
<211>  149
<212>  PRT
<213>  Homo sapiens

<400>  945


Met Ala Gly Ile Thr Thr Ile Glu Ala Val Lys Arg Lys Ile Gln Val 
1               5                   10                  15      


Leu Gln Gln Gln Ala Asp Asp Ala Glu Glu Arg Ala Glu Arg Leu Gln 
            20                  25                  30          


Arg Glu Val Glu Gly Glu Arg Arg Ala Arg Glu Gln Ala Glu Ala Glu 
        35                  40                  45              


Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu Glu Glu Leu Asp 
    50                  55                  60                  


Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys Leu Glu Glu Ala 
65                  70                  75                  80  


Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys Val Ile Glu Asn 
                85                  90                  95      


Arg Ala Leu Lys Asp Glu Glu Lys Met Glu Leu Gln Glu Ile Gln Leu 
            100                 105                 110         


Lys Glu Ala Lys His Ile Ala Glu Glu Ala Asp Arg Lys Tyr Glu Glu 
        115                 120                 125             


Val Ala Arg Lys Leu Val Ile Ile Glu Gly Asp Leu Glu Arg Thr Glu 
    130                 135                 140                 


Glu Arg Ala Asp Leu 
145                 

<210>  946
<211>  3176
<212>  DNA
<213>  Homo sapiens

<400>  946
agggcgtagc aggcggaagt aagggtgaga ggaggctgca acgccgagcg gaggaggcag     60

gaaccggagc gcgagcagta gctgggtggg caccatggct gggatcacca ccatcgaggc    120

ggtgaagcgc aagatccagg ttctgcagca gcaggcagat gatgcagagg agcgagctga    180

gcgcctccag cgagaagttg agggagaaag gcgggcccgg gaacaggctg aggctgaggt    240

ggcctccttg aaccgtagga tccagctggt tgaagaagag ctggaccgtg ctcaggagcg    300

cctggccact gccctgcaaa agctggaaga agctgaaaaa gctgctgatg agagtgagag    360

aggtatgaag gttattgaaa accgggcctt aaaagatgaa gaaaagatgg aactccagga    420

aatccaactc aaagaagcta agcacattgc agaagaggca gataggaagt atgaagaggt    480

ggctcgtaag ttggtgatca ttgaaggaga cttggaacgc acagaggaac gagctgagct    540

ggcagagtct aagtgttctg agctggagga ggagctgaag aatgtcacca acaacctcaa    600

gtctcttgag gctcaggcgg agaagtactc tcaaaaagaa gataaatatg aggaagaaat    660

caagattctt actgataaac tcaaggaggc agagacccgt gctgagtttg ctgagagatc    720

ggtagccaag ctggaaaaga caattgatga cctggaagat aaactgaaat gcaccaaaga    780

ggagcacctc tgtacacaaa ggatgctgga ccagaccctg cttgacctga atgagatgta    840

gaacgcccca gtcccaccct gctgctgctc ctccctctga cccagactcc gcctgaggcc    900

agcctgcggg aagctgacct ttaactgagg gctgatcttt aactggaagg ctgctttctc    960

ctttcaccac cccctccttc cctgtgtctt tttcgccaaa ctgtctctgc ctcttcccgg   1020

agaatccagc tgggctagag gctgagcacc tttggaaaca acatttaagg gaatgtgagc   1080

acaatgcata atgtctttaa aaagcatgtt gtgatgtaca cattttgtaa ttaccttttt   1140

tgttgttttg tagcaaccat ttgtaaaaca ttccaaataa ttccacagtc ctgaagcagc   1200

aatcgaatcc ctttctcact tttggaaggt gacttttcac cttaatgcat attcccctct   1260

ccatagagga gaggaaaagg tgtaggcctg ccttaccgag agccaaacag agcccaggga   1320

gactccgctg tgggaaacct cattgttctg tacaaagtac tagctaaacc agaaaggtga   1380

ttccaggagg agttagccaa acaacaacaa aaacaaaaaa tgtgctgttc aagttttcag   1440

ctttaagata tctttggata atgttatttc tattttttat ttttttcatt agaagttacc   1500

aaattaagat ggtaagacct ctgagaccaa aattttgtcc catctctacc ccctcacaac   1560

tgcttacaga atggatcatg tcccccttat gttgaggtga ccacttaatt gctttcctgc   1620

ctccttgaaa gaaagaaaga aagaagactg tgtttttgcc actgatttag ccatgtgaaa   1680

ctcatctcat tacccttttc tgggtttgaa gctgctgtct ctagaagtgc catctcaatt   1740

gtgctttgta tcagtcagtg ctggagaaat cttgaatagc ttatgtacaa aactttttaa   1800

attttatatt attttgaaac tttgctttgg gtttgtggca ccctggccac cccatctggc   1860

tgtgacagcc tctgcagtcc gtgggctggc agtttgttga tcttttaagt ttccttccct   1920

acccagtccc cattttctgg taaggtttct aggaggtctg ttaggtgtac atcctgcagc   1980

ttattggctt aaaatgtact ctccttttat gtggtctctt tggggccgat tgggagaaag   2040

agaaatcaat agtgcaactg ttttgatact gaatattgac aagtgtcttt ttgaaataaa   2100

gaaccagtcc ctccaaccct cagacctatt tgacttttat ttattaaaac taaatgtgct   2160

ttctccacag aagctatgag gtttgggtta aaaatagcat ctttgtgggt ggtagcaaca   2220

ggatttattc tttattatta ttatttttga gatgaagttt cattcttgtt gcctgggctg   2280

gagcgtaatg gctcgatctc ggctcactgc aacctccgcc tcctggttca agagattctc   2340

ctgcctcagc ctcccgagta gctgggatta caggcacctg ccaccatgcc cgggtaattt   2400

tttatatttt aagtagagac agggcttcac catgttggcc aggctggtct cgaactcctg   2460

accttcaggt gatccacctg cctcagcttc ccaaaatgct gggattacgg gcgtgagcca   2520

ccgcacccag ctggagcaac aggatttaat atagagcaaa tgtttagttt tatcatctgt   2580

aaaatggaga taagtattgt cagagtaaac atgaagatta gaaagaacac ttaatgtgct   2640

gggcctttta taggttaaca ctgacatctc aggctgaact atatacattt tccttcacaa   2700

ccatatcaat ccttataaac tatggattta tgctccttaa aacaatatat aatgctgatc   2760

actactataa atgcgtggtt ttaaccaact gtactgaaac agctttgagt ttatattctg   2820

tttggatatt tggagaaaac aacaagtgct ctcaagagta tttgcttaga ggccggctgt   2880

gtgagtggat aactttgaaa gctgcttttg agacgccagt gtctggcatt tcctgcattc   2940

tggcctggag gccggacgtg aatctgactt ctagtaaaaa tacacggttc ccttgacaaa   3000

gtcgagctgt ttatcccaga gactgcacaa ttttccgttg ataggcatgg accaatgcta   3060

actggaaatc attgcaaaaa gtttttttgt cgggcggagg gtgtggtgtt aagataaaca   3120

gtgtgcaaca gaagaaatta aaactggaag aaattaaagg gtttttttta gacttt       3176


<210>  947
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  947


Met Ala Gly Ile Thr Thr Ile Glu Ala Val Lys Arg Lys Ile Gln Val 
1               5                   10                  15      


Leu Gln Gln Gln Ala Asp Asp Ala Glu Glu Arg Ala Glu Arg Leu Gln 
            20                  25                  30          


Arg Glu Val Glu Gly Glu Arg Arg Ala Arg Glu Gln Ala Glu Ala Glu 
        35                  40                  45              


Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu Glu Glu Leu Asp 
    50                  55                  60                  


Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys Leu Glu Glu Ala 
65                  70                  75                  80  


Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys Val Ile Glu Asn 
                85                  90                  95      


Arg Ala Leu Lys Asp Glu Glu Lys Met Glu Leu Gln Glu Ile Gln Leu 
            100                 105                 110         


Lys Glu Ala Lys His Ile Ala Glu Glu Ala Asp Arg Lys Tyr Glu Glu 
        115                 120                 125             


Val Ala Arg Lys Leu Val Ile Ile Glu Gly Asp Leu Glu Arg Thr Glu 
    130                 135                 140                 


Glu Arg Ala Glu Leu Ala Glu Ser Lys Cys Ser Glu Leu Glu Glu Glu 
145                 150                 155                 160 


Leu Lys Asn Val Thr Asn Asn Leu Lys Ser Leu Glu Ala Gln Ala Glu 
                165                 170                 175     


Lys Tyr Ser Gln Lys Glu Asp Lys Tyr Glu Glu Glu Ile Lys Ile Leu 
            180                 185                 190         


Thr Asp Lys Leu Lys Glu Ala Glu Thr Arg Ala Glu Phe Ala Glu Arg 
        195                 200                 205             


Ser Val Ala Lys Leu Glu Lys Thr Ile Asp Asp Leu Glu Asp Lys Leu 
    210                 215                 220                 


Lys Cys Thr Lys Glu Glu His Leu Cys Thr Gln Arg Met Leu Asp Gln 
225                 230                 235                 240 


Thr Leu Leu Asp Leu Asn Glu Met 
                245             

<210>  948
<211>  2737
<212>  DNA
<213>  Homo sapiens

<400>  948
agggcgtagc aggcggaagt aagggtgaga ggaggctgca acgccgagcg gaggaggcag     60

gaaccggagc gcgagcagta gctgggtggg caccatggct gggatcacca ccatcgaggc    120

ggtgaagcgc aagatccagg ttctgcagca gcaggcagat gatgcagagg agcgagctga    180

gcgcctccag cgagaagttg agggagaaag gcgggcccgg gaacaggctg aggctgaggt    240

ggcctccttg aaccgtagga tccagctggt tgaagaagag ctggaccgtg ctcaggagcg    300

cctggccact gccctgcaaa agctggaaga agctgaaaaa gctgctgatg agagtgagag    360

gtgatgctgg accagaccct gcttgacctg aatgagatgt agaacgcccc agtcccaccc    420

tgctgctgct cctccctctg acccagactc cgcctgaggc cagcctgcgg gaagctgacc    480

tttaactgag ggctgatctt taactggaag gctgctttct cctttcacca ccccctcctt    540

ccctgtgtct ttttcgccaa actgtctctg cctcttcccg gagaatccag ctgggctaga    600

ggctgagcac ctttggaaac aacatttaag ggaatgtgag cacaatgcat aatgtcttta    660

aaaagcatgt tgtgatgtac acattttgta attacctttt ttgttgtttt gtagcaacca    720

tttgtaaaac attccaaata attccacagt cctgaagcag caatcgaatc cctttctcac    780

ttttggaagg tgacttttca ccttaatgca tattcccctc tccatagagg agaggaaaag    840

gtgtaggcct gccttaccga gagccaaaca gagcccaggg agactccgct gtgggaaacc    900

tcattgttct gtacaaagta ctagctaaac cagaaaggtg attccaggag gagttagcca    960

aacaacaaca aaaacaaaaa atgtgctgtt caagttttca gctttaagat atctttggat   1020

aatgttattt ctatttttta tttttttcat tagaagttac caaattaaga tggtaagacc   1080

tctgagacca aaattttgtc ccatctctac cccctcacaa ctgcttacag aatggatcat   1140

gtccccctta tgttgaggtg accacttaat tgctttcctg cctccttgaa agaaagaaag   1200

aaagaagact gtgtttttgc cactgattta gccatgtgaa actcatctca ttaccctttt   1260

ctgggtttga agctgctgtc tctagaagtg ccatctcaat tgtgctttgt atcagtcagt   1320

gctggagaaa tcttgaatag cttatgtaca aaacttttta aattttatat tattttgaaa   1380

ctttgctttg ggtttgtggc accctggcca ccccatctgg ctgtgacagc ctctgcagtc   1440

cgtgggctgg cagtttgttg atcttttaag tttccttccc tacccagtcc ccattttctg   1500

gtaaggtttc taggaggtct gttaggtgta catcctgcag cttattggct taaaatgtac   1560

tctcctttta tgtggtctct ttggggccga ttgggagaaa gagaaatcaa tagtgcaact   1620

gttttgatac tgaatattga caagtgtctt tttgaaataa agaaccagtc cctccaaccc   1680

tcagacctat ttgactttta tttattaaaa ctaaatgtgc tttctccaca gaagctatga   1740

ggtttgggtt aaaaatagca tctttgtggg tggtagcaac aggatttatt ctttattatt   1800

attatttttg agatgaagtt tcattcttgt tgcctgggct ggagcgtaat ggctcgatct   1860

cggctcactg caacctccgc ctcctggttc aagagattct cctgcctcag cctcccgagt   1920

agctgggatt acaggcacct gccaccatgc ccgggtaatt ttttatattt taagtagaga   1980

cagggcttca ccatgttggc caggctggtc tcgaactcct gaccttcagg tgatccacct   2040

gcctcagctt cccaaaatgc tgggattacg ggcgtgagcc accgcaccca gctggagcaa   2100

caggatttaa tatagagcaa atgtttagtt ttatcatctg taaaatggag ataagtattg   2160

tcagagtaaa catgaagatt agaaagaaca cttaatgtgc tgggcctttt ataggttaac   2220

actgacatct caggctgaac tatatacatt ttccttcaca accatatcaa tccttataaa   2280

ctatggattt atgctcctta aaacaatata taatgctgat cactactata aatgcgtggt   2340

tttaaccaac tgtactgaaa cagctttgag tttatattct gtttggatat ttggagaaaa   2400

caacaagtgc tctcaagagt atttgcttag aggccggctg tgtgagtgga taactttgaa   2460

agctgctttt gagacgccag tgtctggcat ttcctgcatt ctggcctgga ggccggacgt   2520

gaatctgact tctagtaaaa atacacggtt cccttgacaa agtcgagctg tttatcccag   2580

agactgcaca attttccgtt gataggcatg gaccaatgct aactggaaat cattgcaaaa   2640

agtttttttg tcgggcggag ggtgtggtgt taagataaac agtgtgcaac agaagaaatt   2700

aaaactggaa gaaattaaag ggtttttttt agacttt                            2737


<210>  949
<211>  89
<212>  PRT
<213>  Homo sapiens

<400>  949


Met Ala Gly Ile Thr Thr Ile Glu Ala Val Lys Arg Lys Ile Gln Val 
1               5                   10                  15      


Leu Gln Gln Gln Ala Asp Asp Ala Glu Glu Arg Ala Glu Arg Leu Gln 
            20                  25                  30          


Arg Glu Val Glu Gly Glu Arg Arg Ala Arg Glu Gln Ala Glu Ala Glu 
        35                  40                  45              


Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu Glu Glu Leu Asp 
    50                  55                  60                  


Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys Leu Glu Glu Ala 
65                  70                  75                  80  


Glu Lys Ala Ala Asp Glu Ser Glu Arg 
                85                  

<210>  950
<211>  1981
<212>  DNA
<213>  Homo sapiens

<400>  950
agggcgtagc aggcggaagt aagggtgaga ggaggctgca acgccgagcg gaggaggcag     60

gaaccggagc gcgagcagta gctgggtggg caccatggct gggatcacca ccatcgaggc    120

ggtgaagcgc aagatccagg ttctgcagca gcaggcagat gatgcagagg agcgagctga    180

gcgcctccag cgagaagttg agggagaaag gcgggcccgg gaacaggctg aggctgaggt    240

ggcctccttg aaccgtagga tccagctggt tgaagaagag ctggaccgtg ctcaggagcg    300

cctggccact gccctgcaaa agctggaaga agctgaaaaa gctgctgatg agagtgagag    360

aggtatgaag gttattgaaa accgggcctt aaaagatgaa gaaaagatgg aactccagga    420

aatccaactc aaagaaaaag aaagaaagaa gactgtgttt ttgccactga tttagccatg    480

tgaaactcat ctcattaccc ttttctgggt ttgaagctgc tgtctctaga agtgccatct    540

caattgtgct ttgtatcagt cagtgctgga gaaatcttga atagcttatg tacaaaactt    600

tttaaatttt atattatttt gaaactttgc tttgggtttg tggcaccctg gccaccccat    660

ctggctgtga cagcctctgc agtccgtggg ctggcagttt gttgatcttt taagtttcct    720

tccctaccca gtccccattt tctggtaagg tttctaggag gtctgttagg tgtacatcct    780

gcagcttatt ggcttaaaat gtactctcct tttatgtggt ctctttgggg ccgattggga    840

gaaagagaaa tcaatagtgc aactgttttg atactgaata ttgacaagtg tctttttgaa    900

ataaagaacc agtccctcca accctcagac ctatttgact tttatttatt aaaactaaat    960

gtgctttctc cacagaagct atgaggtttg ggttaaaaat agcatctttg tgggtggtag   1020

caacaggatt tattctttat tattattatt tttgagatga agtttcattc ttgttgcctg   1080

ggctggagcg taatggctcg atctcggctc actgcaacct ccgcctcctg gttcaagaga   1140

ttctcctgcc tcagcctccc gagtagctgg gattacaggc acctgccacc atgcccgggt   1200

aattttttat attttaagta gagacagggc ttcaccatgt tggccaggct ggtctcgaac   1260

tcctgacctt caggtgatcc acctgcctca gcttcccaaa atgctgggat tacgggcgtg   1320

agccaccgca cccagctgga gcaacaggat ttaatataga gcaaatgttt agttttatca   1380

tctgtaaaat ggagataagt attgtcagag taaacatgaa gattagaaag aacacttaat   1440

gtgctgggcc ttttataggt taacactgac atctcaggct gaactatata cattttcctt   1500

cacaaccata tcaatcctta taaactatgg atttatgctc cttaaaacaa tatataatgc   1560

tgatcactac tataaatgcg tggttttaac caactgtact gaaacagctt tgagtttata   1620

ttctgtttgg atatttggag aaaacaacaa gtgctctcaa gagtatttgc ttagaggccg   1680

gctgtgtgag tggataactt tgaaagctgc ttttgagacg ccagtgtctg gcatttcctg   1740

cattctggcc tggaggccgg acgtgaatct gacttctagt aaaaatacac ggttcccttg   1800

acaaagtcga gctgtttatc ccagagactg cacaattttc cgttgatagg catggaccaa   1860

tgctaactgg aaatcattgc aaaaagtttt tttgtcgggc ggagggtgtg gtgttaagat   1920

aaacagtgtg caacagaaga aattaaaact ggaagaaatt aaagggtttt ttttagactt   1980

t                                                                   1981


<210>  951
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  951


Met Ala Gly Ile Thr Thr Ile Glu Ala Val Lys Arg Lys Ile Gln Val 
1               5                   10                  15      


Leu Gln Gln Gln Ala Asp Asp Ala Glu Glu Arg Ala Glu Arg Leu Gln 
            20                  25                  30          


Arg Glu Val Glu Gly Glu Arg Arg Ala Arg Glu Gln Ala Glu Ala Glu 
        35                  40                  45              


Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu Glu Glu Leu Asp 
    50                  55                  60                  


Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys Leu Glu Glu Ala 
65                  70                  75                  80  


Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys Val Ile Glu Asn 
                85                  90                  95      


Arg Ala Leu Lys Asp Glu Glu Lys Met Glu Leu Gln Glu Ile Gln Leu 
            100                 105                 110         


Lys Glu Lys Glu Arg Lys Lys Thr Val Phe Leu Pro Leu Ile 
        115                 120                 125     

<210>  952
<211>  2981
<212>  DNA
<213>  Homo sapiens

<400>  952
cagggcgtag caggcggaag taagggtgag aggaggctgc aacgccgagc ggaggaggca     60

ggaaccggag cgcgagcagt agctgggtgg gcaccatggc tgggatcacc accatcgagg    120

cggtgaagcg caagatccag gttctgcagc agcaggcaga tgatgcagag gagcgagctg    180

agcgcctcca gcgagaagtt gagggaaaaa gatggaactc caggaaatcc aactcaaaga    240

agctaagcac attgcagaag aggcagatag gaagtatgaa gaggtggctc gtaagttggt    300

gatcattgaa ggagacttgg aacgcacaga ggaacgagct gagctggcag agtcccgttg    360

ccgagagatg gatgagcaga ttagactgat ggaccagaac ctgaagtgtc tgagtgctgc    420

tgaagaaaag tactctcaaa aagaagataa atatgaggaa gaaatcaaga ttcttactga    480

taaactcaag gaggcagaga cccgtgctga gtttgctgag agatcggtag ccaagctgga    540

aaagacaatt gatgacctgg aagataaact gaaatgcacc aaagaggagc acctctgtac    600

acaaaggatg ctggaccaga ccctgcttga cctgaatgag atgtagaacg ccccagtccc    660

accctgctgc tgctcctccc tctgacccag actccgcctg aggccagcct gcgggaagct    720

gacctttaac tgagggctga tctttaactg gaaggctgct ttctcctttc accaccccct    780

ccttccctgt gtctttttcg ccaaactgtc tctgcctctt cccggagaat ccagctgggc    840

tagaggctga gcacctttgg aaacaacatt taagggaatg tgagcacaat gcataatgtc    900

tttaaaaagc atgttgtgat gtacacattt tgtaattacc ttttttgttg ttttgtagca    960

accatttgta aaacattcca aataattcca cagtcctgaa gcagcaatcg aatccctttc   1020

tcacttttgg aaggtgactt ttcaccttaa tgcatattcc cctctccata gaggagagga   1080

aaaggtgtag gcctgcctta ccgagagcca aacagagccc agggagactc cgctgtggga   1140

aacctcattg ttctgtacaa agtactagct aaaccagaaa ggtgattcca ggaggagtta   1200

gccaaacaac aacaaaaaca aaaaatgtgc tgttcaagtt ttcagcttta agatatcttt   1260

ggataatgtt atttctattt tttatttttt tcattagaag ttaccaaatt aagatggtaa   1320

gacctctgag accaaaattt tgtcccatct ctaccccctc acaactgctt acagaatgga   1380

tcatgtcccc cttatgttga ggtgaccact taattgcttt cctgcctcct tgaaagaaag   1440

aaagaaagaa gactgtgttt ttgccactga tttagccatg tgaaactcat ctcattaccc   1500

ttttctgggt ttgaagctgc tgtctctaga agtgccatct caattgtgct ttgtatcagt   1560

cagtgctgga gaaatcttga atagcttatg tacaaaactt tttaaatttt atattatttt   1620

gaaactttgc tttgggtttg tggcaccctg gccaccccat ctggctgtga cagcctctgc   1680

agtccgtggg ctggcagttt gttgatcttt taagtttcct tccctaccca gtccccattt   1740

tctggtaagg tttctaggag gtctgttagg tgtacatcct gcagcttatt ggcttaaaat   1800

gtactctcct tttatgtggt ctctttgggg ccgattggga gaaagagaaa tcaatagtgc   1860

aactgttttg atactgaata ttgacaagtg tctttttgaa ataaagaacc agtccctcca   1920

accctcagac ctatttgact tttatttatt aaaactaaat gtgctttctc cacagaagct   1980

atgaggtttg ggttaaaaat agcatctttg tgggtggtag caacaggatt tattctttat   2040

tattattatt tttgagatga agtttcattc ttgttgcctg ggctggagcg taatggctcg   2100

atctcggctc actgcaacct ccgcctcctg gttcaagaga ttctcctgcc tcagcctccc   2160

gagtagctgg gattacaggc acctgccacc atgcccgggt aattttttat attttaagta   2220

gagacagggc ttcaccatgt tggccaggct ggtctcgaac tcctgacctt caggtgatcc   2280

acctgcctca gcttcccaaa atgctgggat tacgggcgtg agccaccgca cccagctgga   2340

gcaacaggat ttaatataga gcaaatgttt agttttatca tctgtaaaat ggagataagt   2400

attgtcagag taaacatgaa gattagaaag aacacttaat gtgctgggcc ttttataggt   2460

taacactgac atctcaggct gaactatata cattttcctt cacaaccata tcaatcctta   2520

taaactatgg atttatgctc cttaaaacaa tatataatgc tgatcactac tataaatgcg   2580

tggttttaac caactgtact gaaacagctt tgagtttata ttctgtttgg atatttggag   2640

aaaacaacaa gtgctctcaa gagtatttgc ttagaggccg gctgtgtgag tggataactt   2700

tgaaagctgc ttttgagacg ccagtgtctg gcatttcctg cattctggcc tggaggccgg   2760

acgtgaatct gacttctagt aaaaatacac ggttcccttg acaaagtcga gctgtttatc   2820

ccagagactg cacaattttc cgttgatagg catggaccaa tgctaactgg aaatcattgc   2880

aaaaagtttt tttgtcgggc ggagggtgtg gtgttaagat aaacagtgtg caacagaaga   2940

aattaaaact ggaagaaatt aaagggtttt ttttagactt t                       2981


<210>  953
<211>  144
<212>  PRT
<213>  Homo sapiens

<400>  953


Met Glu Leu Gln Glu Ile Gln Leu Lys Glu Ala Lys His Ile Ala Glu 
1               5                   10                  15      


Glu Ala Asp Arg Lys Tyr Glu Glu Val Ala Arg Lys Leu Val Ile Ile 
            20                  25                  30          


Glu Gly Asp Leu Glu Arg Thr Glu Glu Arg Ala Glu Leu Ala Glu Ser 
        35                  40                  45              


Arg Cys Arg Glu Met Asp Glu Gln Ile Arg Leu Met Asp Gln Asn Leu 
    50                  55                  60                  


Lys Cys Leu Ser Ala Ala Glu Glu Lys Tyr Ser Gln Lys Glu Asp Lys 
65                  70                  75                  80  


Tyr Glu Glu Glu Ile Lys Ile Leu Thr Asp Lys Leu Lys Glu Ala Glu 
                85                  90                  95      


Thr Arg Ala Glu Phe Ala Glu Arg Ser Val Ala Lys Leu Glu Lys Thr 
            100                 105                 110         


Ile Asp Asp Leu Glu Asp Lys Leu Lys Cys Thr Lys Glu Glu His Leu 
        115                 120                 125             


Cys Thr Gln Arg Met Leu Asp Gln Thr Leu Leu Asp Leu Asn Glu Met 
    130                 135                 140                 

<210>  954
<211>  2927
<212>  DNA
<213>  Homo sapiens

<400>  954
tttcagggcg tagcaggcgg aagtaagggt gagaggaggc tgcaacgccg agcggaggag     60

gcaggaaccg gagcgcgagc agtagctggg tgggcaccat ggctgggatc accaccatcg    120

aggcggtgaa gcgcaagatc caggttctgc agcagcaggc agatgatgca gaggagcgag    180

ctgagcgcct ccagcgagaa gttgagggag aaaggcgggc ccgggaacag gctgaggctg    240

aggtggcctc cttgaaccgt aggatccagc tggttgaaga agagctggac cgtgctcagg    300

agcgcctggc cactgccctg caaaagctgg aagaagctga aaaagctgct gatgagagtg    360

agagaggtat gaaggttatt gaaaaccggg ccttaaaaga tgaagaaaag atggaactcc    420

aggaaatcca actcaaagaa gctaagcaca ttgcagaaga ggcagatagg aagtatgaag    480

aggtggctcg taagttggtg atcattgaag gagacttgga acgcacagag gaacgagctg    540

agctggcaga gtcccgttgc cgagagatgg atgagcagat tagactgatg gaccagaacc    600

tgaagtgtct gagtgctgct cctccctctg acccagactc cgcctgaggc cagcctgcgg    660

gaagctgacc tttaactgag ggctgatctt taactggaag gctgctttct cctttcacca    720

ccccctcctt ccctgtgtct ttttcgccaa actgtctctg cctcttcccg gagaatccag    780

ctgggctaga ggctgagcac ctttggaaac aacatttaag ggaatgtgag cacaatgcat    840

aatgtcttta aaaagcatgt tgtgatgtac acattttgta attacctttt ttgttgtttt    900

gtagcaacca tttgtaaaac attccaaata attccacagt cctgaagcag caatcgaatc    960

cctttctcac ttttggaagg tgacttttca ccttaatgca tattcccctc tccatagagg   1020

agaggaaaag gtgtaggcct gccttaccga gagccaaaca gagcccaggg agactccgct   1080

gtgggaaacc tcattgttct gtacaaagta ctagctaaac cagaaaggtg attccaggag   1140

gagttagcca aacaacaaca aaaacaaaaa atgtgctgtt caagttttca gctttaagat   1200

atctttggat aatgttattt ctatttttta tttttttcat tagaagttac caaattaaga   1260

tggtaagacc tctgagacca aaattttgtc ccatctctac cccctcacaa ctgcttacag   1320

aatggatcat gtccccctta tgttgaggtg accacttaat tgctttcctg cctccttgaa   1380

agaaagaaag aaagaagact gtgtttttgc cactgattta gccatgtgaa actcatctca   1440

ttaccctttt ctgggtttga agctgctgtc tctagaagtg ccatctcaat tgtgctttgt   1500

atcagtcagt gctggagaaa tcttgaatag cttatgtaca aaacttttta aattttatat   1560

tattttgaaa ctttgctttg ggtttgtggc accctggcca ccccatctgg ctgtgacagc   1620

ctctgcagtc cgtgggctgg cagtttgttg atcttttaag tttccttccc tacccagtcc   1680

ccattttctg gtaaggtttc taggaggtct gttaggtgta catcctgcag cttattggct   1740

taaaatgtac tctcctttta tgtggtctct ttggggccga ttgggagaaa gagaaatcaa   1800

tagtgcaact gttttgatac tgaatattga caagtgtctt tttgaaataa agaaccagtc   1860

cctccaaccc tcagacctat ttgactttta tttattaaaa ctaaatgtgc tttctccaca   1920

gaagctatga ggtttgggtt aaaaatagca tctttgtggg tggtagcaac aggatttatt   1980

ctttattatt attatttttg agatgaagtt tcattcttgt tgcctgggct ggagcgtaat   2040

ggctcgatct cggctcactg caacctccgc ctcctggttc aagagattct cctgcctcag   2100

cctcccgagt agctgggatt acaggcacct gccaccatgc ccgggtaatt ttttatattt   2160

taagtagaga cagggcttca ccatgttggc caggctggtc tcgaactcct gaccttcagg   2220

tgatccacct gcctcagctt cccaaaatgc tgggattacg ggcgtgagcc accgcaccca   2280

gctggagcaa caggatttaa tatagagcaa atgtttagtt ttatcatctg taaaatggag   2340

ataagtattg tcagagtaaa catgaagatt agaaagaaca cttaatgtgc tgggcctttt   2400

ataggttaac actgacatct caggctgaac tatatacatt ttccttcaca accatatcaa   2460

tccttataaa ctatggattt atgctcctta aaacaatata taatgctgat cactactata   2520

aatgcgtggt tttaaccaac tgtactgaaa cagctttgag tttatattct gtttggatat   2580

ttggagaaaa caacaagtgc tctcaagagt atttgcttag aggccggctg tgtgagtgga   2640

taactttgaa agctgctttt gagacgccag tgtctggcat ttcctgcatt ctggcctgga   2700

ggccggacgt gaatctgact tctagtaaaa atacacggtt cccttgacaa agtcgagctg   2760

tttatcccag agactgcaca attttccgtt gataggcatg gaccaatgct aactggaaat   2820

cattgcaaaa agtttttttg tcgggcggag ggtgtggtgt taagataaac agtgtgcaac   2880

agaagaaatt aaaactggaa gaaattaaag ggtttttttt agacttt                 2927


<210>  955
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  955


Met Ala Gly Ile Thr Thr Ile Glu Ala Val Lys Arg Lys Ile Gln Val 
1               5                   10                  15      


Leu Gln Gln Gln Ala Asp Asp Ala Glu Glu Arg Ala Glu Arg Leu Gln 
            20                  25                  30          


Arg Glu Val Glu Gly Glu Arg Arg Ala Arg Glu Gln Ala Glu Ala Glu 
        35                  40                  45              


Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu Glu Glu Leu Asp 
    50                  55                  60                  


Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys Leu Glu Glu Ala 
65                  70                  75                  80  


Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys Val Ile Glu Asn 
                85                  90                  95      


Arg Ala Leu Lys Asp Glu Glu Lys Met Glu Leu Gln Glu Ile Gln Leu 
            100                 105                 110         


Lys Glu Ala Lys His Ile Ala Glu Glu Ala Asp Arg Lys Tyr Glu Glu 
        115                 120                 125             


Val Ala Arg Lys Leu Val Ile Ile Glu Gly Asp Leu Glu Arg Thr Glu 
    130                 135                 140                 


Glu Arg Ala Glu Leu Ala Glu Ser Arg Cys Arg Glu Met Asp Glu Gln 
145                 150                 155                 160 


Ile Arg Leu Met Asp Gln Asn Leu Lys Cys Leu Ser Ala Ala Pro Pro 
                165                 170                 175     


Ser Asp Pro Asp Ser Ala 
            180         

<210>  956
<211>  2926
<212>  DNA
<213>  Homo sapiens

<400>  956
atttcagggc gtagcaggcg gaagtaaggg tgagaggagg ctgcaacgcc gagcggagga     60

ggcaggaacc ggagcgcgag cagtagctgg gtgggcacca tggctgggat caccaccatc    120

gaggcggtga agcgcaagat ccaggttctg cagcagcagg cagatgatgc agaggagcga    180

gctgagcgcc tccagcgaga agttgaggga gaaaggcggg cccgggaaca ggctgaggct    240

gaggtggcct ccttgaaccg taggatccag ctggttgaag aagagctgga ccgtgctcag    300

gagcgcctgg ccactgccct gcaaaagctg gaagaagctg aaaaagctgc tgatgagagt    360

gagagaggta tgaaggttat tgaaaaccgg gccttaaaag atgaagaaaa gatggaactc    420

caggaaatcc aactcaaaga agctaagcac attgcagaag aggcagatag gaagtatgaa    480

gaggtggctc gtaagttggt gatcattgaa ggagacttgg aacgcacaga ggaacgagct    540

gagctggcag agtcgtgaga ccagaccctg cttgacctga atgagatgta gaacgcccca    600

gtcccaccct gctgctgctc ctccctctga cccagactcc gcctgaggcc agcctgcggg    660

aagctgacct ttaactgagg gctgatcttt aactggaagg ctgctttctc ctttcaccac    720

cccctccttc cctgtgtctt tttcgccaaa ctgtctctgc ctcttcccgg agaatccagc    780

tgggctagag gctgagcacc tttggaaaca acatttaagg gaatgtgagc acaatgcata    840

atgtctttaa aaagcatgtt gtgatgtaca cattttgtaa ttaccttttt tgttgttttg    900

tagcaaccat ttgtaaaaca ttccaaataa ttccacagtc ctgaagcagc aatcgaatcc    960

ctttctcact tttggaaggt gacttttcac cttaatgcat attcccctct ccatagagga   1020

gaggaaaagg tgtaggcctg ccttaccgag agccaaacag agcccaggga gactccgctg   1080

tgggaaacct cattgttctg tacaaagtac tagctaaacc agaaaggtga ttccaggagg   1140

agttagccaa acaacaacaa aaacaaaaaa tgtgctgttc aagttttcag ctttaagata   1200

tctttggata atgttatttc tattttttat ttttttcatt agaagttacc aaattaagat   1260

ggtaagacct ctgagaccaa aattttgtcc catctctacc ccctcacaac tgcttacaga   1320

atggatcatg tcccccttat gttgaggtga ccacttaatt gctttcctgc ctccttgaaa   1380

gaaagaaaga aagaagactg tgtttttgcc actgatttag ccatgtgaaa ctcatctcat   1440

tacccttttc tgggtttgaa gctgctgtct ctagaagtgc catctcaatt gtgctttgta   1500

tcagtcagtg ctggagaaat cttgaatagc ttatgtacaa aactttttaa attttatatt   1560

attttgaaac tttgctttgg gtttgtggca ccctggccac cccatctggc tgtgacagcc   1620

tctgcagtcc gtgggctggc agtttgttga tcttttaagt ttccttccct acccagtccc   1680

cattttctgg taaggtttct aggaggtctg ttaggtgtac atcctgcagc ttattggctt   1740

aaaatgtact ctccttttat gtggtctctt tggggccgat tgggagaaag agaaatcaat   1800

agtgcaactg ttttgatact gaatattgac aagtgtcttt ttgaaataaa gaaccagtcc   1860

ctccaaccct cagacctatt tgacttttat ttattaaaac taaatgtgct ttctccacag   1920

aagctatgag gtttgggtta aaaatagcat ctttgtgggt ggtagcaaca ggatttattc   1980

tttattatta ttatttttga gatgaagttt cattcttgtt gcctgggctg gagcgtaatg   2040

gctcgatctc ggctcactgc aacctccgcc tcctggttca agagattctc ctgcctcagc   2100

ctcccgagta gctgggatta caggcacctg ccaccatgcc cgggtaattt tttatatttt   2160

aagtagagac agggcttcac catgttggcc aggctggtct cgaactcctg accttcaggt   2220

gatccacctg cctcagcttc ccaaaatgct gggattacgg gcgtgagcca ccgcacccag   2280

ctggagcaac aggatttaat atagagcaaa tgtttagttt tatcatctgt aaaatggaga   2340

taagtattgt cagagtaaac atgaagatta gaaagaacac ttaatgtgct gggcctttta   2400

taggttaaca ctgacatctc aggctgaact atatacattt tccttcacaa ccatatcaat   2460

ccttataaac tatggattta tgctccttaa aacaatatat aatgctgatc actactataa   2520

atgcgtggtt ttaaccaact gtactgaaac agctttgagt ttatattctg tttggatatt   2580

tggagaaaac aacaagtgct ctcaagagta tttgcttaga ggccggctgt gtgagtggat   2640

aactttgaaa gctgcttttg agacgccagt gtctggcatt tcctgcattc tggcctggag   2700

gccggacgtg aatctgactt ctagtaaaaa tacacggttc ccttgacaaa gtcgagctgt   2760

ttatcccaga gactgcacaa ttttccgttg ataggcatgg accaatgcta actggaaatc   2820

attgcaaaaa gtttttttgt cgggcggagg gtgtggtgtt aagataaaca gtgtgcaaca   2880

gaagaaatta aaactggaag aaattaaagg gtttttttta gacttt                  2926


<210>  957
<211>  152
<212>  PRT
<213>  Homo sapiens

<400>  957


Met Ala Gly Ile Thr Thr Ile Glu Ala Val Lys Arg Lys Ile Gln Val 
1               5                   10                  15      


Leu Gln Gln Gln Ala Asp Asp Ala Glu Glu Arg Ala Glu Arg Leu Gln 
            20                  25                  30          


Arg Glu Val Glu Gly Glu Arg Arg Ala Arg Glu Gln Ala Glu Ala Glu 
        35                  40                  45              


Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu Glu Glu Leu Asp 
    50                  55                  60                  


Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys Leu Glu Glu Ala 
65                  70                  75                  80  


Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys Val Ile Glu Asn 
                85                  90                  95      


Arg Ala Leu Lys Asp Glu Glu Lys Met Glu Leu Gln Glu Ile Gln Leu 
            100                 105                 110         


Lys Glu Ala Lys His Ile Ala Glu Glu Ala Asp Arg Lys Tyr Glu Glu 
        115                 120                 125             


Val Ala Arg Lys Leu Val Ile Ile Glu Gly Asp Leu Glu Arg Thr Glu 
    130                 135                 140                 


Glu Arg Ala Glu Leu Ala Glu Ser 
145                 150         

<210>  958
<211>  2203
<212>  DNA
<213>  Homo sapiens

<400>  958
tccggtattt cagggcgtag caggcggaag taagggtgag aggaggctgc aacgccgagc     60

ggaggaggca ggaaccggag cgcgagcagt agctgggtgg gcaccatggc tgggatcacc    120

accatcgagg cggtgaagcg caagatccag gttctgcagc agcaggcaga tgatgcagag    180

gagcgagctg agcgcctcca gcgagaagtt gagggagaaa ggcgggcccg ggaacaggct    240

gaggctgagg tggcctcctt gaaccgtagg atccagctgg ttgaagaaga gctggaccgt    300

gctcaggagc gcctggccac tgccctgcaa aagctggaag aagctgaaaa agctgctgat    360

gagagtgaga gaggtatgaa ggttattgaa aaccgggcct taaaagatga agaaaagatg    420

gaactccagg aaatccaact caaagaagct aagcacattg cagaagaggc agataggaag    480

tatgaagagg tggctcgtaa gttggtgatc attgaaggag acttggaacg cacagaggaa    540

cgagctgagc tggcagagtc ccgttgccga gagatggatg agcagattag actgatggac    600

cagaacctga agtgtctgag tgctgctgaa gaaaagtact ctcaaaaaga agataaatat    660

gaggaagaaa aagactgtgt ttttgccact gatttagcca tgtgaaactc atctcattac    720

ccttttctgg gtttgaagct gctgtctcta gaagtgccat ctcaattgtg ctttgtatca    780

gtcagtgctg gagaaatctt gaatagctta tgtacaaaac tttttaaatt ttatattatt    840

ttgaaacttt gctttgggtt tgtggcaccc tggccacccc atctggctgt gacagcctct    900

gcagtccgtg ggctggcagt ttgttgatct tttaagtttc cttccctacc cagtccccat    960

tttctggtaa ggtttctagg aggtctgtta ggtgtacatc ctgcagctta ttggcttaaa   1020

atgtactctc cttttatgtg gtctctttgg ggccgattgg gagaaagaga aatcaatagt   1080

gcaactgttt tgatactgaa tattgacaag tgtctttttg aaataaagaa ccagtccctc   1140

caaccctcag acctatttga cttttattta ttaaaactaa atgtgctttc tccacagaag   1200

ctatgaggtt tgggttaaaa atagcatctt tgtgggtggt agcaacagga tttattcttt   1260

attattatta tttttgagat gaagtttcat tcttgttgcc tgggctggag cgtaatggct   1320

cgatctcggc tcactgcaac ctccgcctcc tggttcaaga gattctcctg cctcagcctc   1380

ccgagtagct gggattacag gcacctgcca ccatgcccgg gtaatttttt atattttaag   1440

tagagacagg gcttcaccat gttggccagg ctggtctcga actcctgacc ttcaggtgat   1500

ccacctgcct cagcttccca aaatgctggg attacgggcg tgagccaccg cacccagctg   1560

gagcaacagg atttaatata gagcaaatgt ttagttttat catctgtaaa atggagataa   1620

gtattgtcag agtaaacatg aagattagaa agaacactta atgtgctggg ccttttatag   1680

gttaacactg acatctcagg ctgaactata tacattttcc ttcacaacca tatcaatcct   1740

tataaactat ggatttatgc tccttaaaac aatatataat gctgatcact actataaatg   1800

cgtggtttta accaactgta ctgaaacagc tttgagttta tattctgttt ggatatttgg   1860

agaaaacaac aagtgctctc aagagtattt gcttagaggc cggctgtgtg agtggataac   1920

tttgaaagct gcttttgaga cgccagtgtc tggcatttcc tgcattctgg cctggaggcc   1980

ggacgtgaat ctgacttcta gtaaaaatac acggttccct tgacaaagtc gagctgttta   2040

tcccagagac tgcacaattt tccgttgata ggcatggacc aatgctaact ggaaatcatt   2100

gcaaaaagtt tttttgtcgg gcggagggtg tggtgttaag ataaacagtg tgcaacagaa   2160

gaaattaaaa ctggaagaaa ttaaagggtt ttttttagac ttt                     2203


<210>  959
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  959


Met Ala Gly Ile Thr Thr Ile Glu Ala Val Lys Arg Lys Ile Gln Val 
1               5                   10                  15      


Leu Gln Gln Gln Ala Asp Asp Ala Glu Glu Arg Ala Glu Arg Leu Gln 
            20                  25                  30          


Arg Glu Val Glu Gly Glu Arg Arg Ala Arg Glu Gln Ala Glu Ala Glu 
        35                  40                  45              


Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu Glu Glu Leu Asp 
    50                  55                  60                  


Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys Leu Glu Glu Ala 
65                  70                  75                  80  


Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys Val Ile Glu Asn 
                85                  90                  95      


Arg Ala Leu Lys Asp Glu Glu Lys Met Glu Leu Gln Glu Ile Gln Leu 
            100                 105                 110         


Lys Glu Ala Lys His Ile Ala Glu Glu Ala Asp Arg Lys Tyr Glu Glu 
        115                 120                 125             


Val Ala Arg Lys Leu Val Ile Ile Glu Gly Asp Leu Glu Arg Thr Glu 
    130                 135                 140                 


Glu Arg Ala Glu Leu Ala Glu Ser Arg Cys Arg Glu Met Asp Glu Gln 
145                 150                 155                 160 


Ile Arg Leu Met Asp Gln Asn Leu Lys Cys Leu Ser Ala Ala Glu Glu 
                165                 170                 175     


Lys Tyr Ser Gln Lys Glu Asp Lys Tyr Glu Glu Glu Lys Asp Cys Val 
            180                 185                 190         


Phe Ala Thr Asp Leu Ala Met 
        195                 

<210>  960
<211>  3124
<212>  DNA
<213>  Homo sapiens

<400>  960
tccggtattt cagggcgtag caggcggaag taagggtgag aggaggctgc aacgccgagc     60

ggaggaggca ggaaccggag cgcgagcagt agctgggtgg gcaccatggc tgggatcacc    120

accatcgagg cggtgaagcg caagatccag gttctgcagc agcaggcaga tgatgcagag    180

gagcgagctg agcgcctcca gcgagaagtt gagggagaaa ggcgggcccg ggaacaggct    240

gaggctgagg tggcctcctt gaaccgtagg atccagctgg ttgaagaaga gctggaccgt    300

gctcaggagc gcctggccac tgccctgcaa aagctggaag aagctgaaaa agctgctgat    360

gagagtgaga gaggtatgaa ggttattgaa aaccgggcct taaaagatga agaaaagatg    420

gaactccagg aaatccaact caaagaagct aagcacattg cagaagaggc agataggaag    480

tatgaagagg tggctcgtaa gttggtgatc attgaaggag acttggaacg cacagaggaa    540

cgagctgagc tggcagagtc ccgttgccga gagatggatg agcagattag actgatggac    600

cagaacctga agtgtctgag tgctgctgaa gaaaaggcag agacccgtgc tgagtttgct    660

gagagatcgg tagccaagct ggaaaagaca attgatgacc tggaagataa actgaaatgc    720

accaaagagg agcacctctg tacacaaagg atgctggacc agaccctgct tgacctgaat    780

gagatgtaga acgccccagt cccaccctgc tgctgctcct ccctctgacc cagactccgc    840

ctgaggccag cctgcgggaa gctgaccttt aactgagggc tgatctttaa ctggaaggct    900

gctttctcct ttcaccaccc cctccttccc tgtgtctttt tcgccaaact gtctctgcct    960

cttcccggag aatccagctg ggctagaggc tgagcacctt tggaaacaac atttaaggga   1020

atgtgagcac aatgcataat gtctttaaaa agcatgttgt gatgtacaca ttttgtaatt   1080

accttttttg ttgttttgta gcaaccattt gtaaaacatt ccaaataatt ccacagtcct   1140

gaagcagcaa tcgaatccct ttctcacttt tggaaggtga cttttcacct taatgcatat   1200

tcccctctcc atagaggaga ggaaaaggtg taggcctgcc ttaccgagag ccaaacagag   1260

cccagggaga ctccgctgtg ggaaacctca ttgttctgta caaagtacta gctaaaccag   1320

aaaggtgatt ccaggaggag ttagccaaac aacaacaaaa acaaaaaatg tgctgttcaa   1380

gttttcagct ttaagatatc tttggataat gttatttcta ttttttattt ttttcattag   1440

aagttaccaa attaagatgg taagacctct gagaccaaaa ttttgtccca tctctacccc   1500

ctcacaactg cttacagaat ggatcatgtc ccccttatgt tgaggtgacc acttaattgc   1560

tttcctgcct ccttgaaaga aagaaagaaa gaagactgtg tttttgccac tgatttagcc   1620

atgtgaaact catctcatta cccttttctg ggtttgaagc tgctgtctct agaagtgcca   1680

tctcaattgt gctttgtatc agtcagtgct ggagaaatct tgaatagctt atgtacaaaa   1740

ctttttaaat tttatattat tttgaaactt tgctttgggt ttgtggcacc ctggccaccc   1800

catctggctg tgacagcctc tgcagtccgt gggctggcag tttgttgatc ttttaagttt   1860

ccttccctac ccagtcccca ttttctggta aggtttctag gaggtctgtt aggtgtacat   1920

cctgcagctt attggcttaa aatgtactct ccttttatgt ggtctctttg gggccgattg   1980

ggagaaagag aaatcaatag tgcaactgtt ttgatactga atattgacaa gtgtcttttt   2040

gaaataaaga accagtccct ccaaccctca gacctatttg acttttattt attaaaacta   2100

aatgtgcttt ctccacagaa gctatgaggt ttgggttaaa aatagcatct ttgtgggtgg   2160

tagcaacagg atttattctt tattattatt atttttgaga tgaagtttca ttcttgttgc   2220

ctgggctgga gcgtaatggc tcgatctcgg ctcactgcaa cctccgcctc ctggttcaag   2280

agattctcct gcctcagcct cccgagtagc tgggattaca ggcacctgcc accatgcccg   2340

ggtaattttt tatattttaa gtagagacag ggcttcacca tgttggccag gctggtctcg   2400

aactcctgac cttcaggtga tccacctgcc tcagcttccc aaaatgctgg gattacgggc   2460

gtgagccacc gcacccagct ggagcaacag gatttaatat agagcaaatg tttagtttta   2520

tcatctgtaa aatggagata agtattgtca gagtaaacat gaagattaga aagaacactt   2580

aatgtgctgg gccttttata ggttaacact gacatctcag gctgaactat atacattttc   2640

cttcacaacc atatcaatcc ttataaacta tggatttatg ctccttaaaa caatatataa   2700

tgctgatcac tactataaat gcgtggtttt aaccaactgt actgaaacag ctttgagttt   2760

atattctgtt tggatatttg gagaaaacaa caagtgctct caagagtatt tgcttagagg   2820

ccggctgtgt gagtggataa ctttgaaagc tgcttttgag acgccagtgt ctggcatttc   2880

ctgcattctg gcctggaggc cggacgtgaa tctgacttct agtaaaaata cacggttccc   2940

ttgacaaagt cgagctgttt atcccagaga ctgcacaatt ttccgttgat aggcatggac   3000

caatgctaac tggaaatcat tgcaaaaagt ttttttgtcg ggcggagggt gtggtgttaa   3060

gataaacagt gtgcaacaga agaaattaaa actggaagaa attaaagggt tttttttaga   3120

cttt                                                                3124


<210>  961
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  961


Met Ala Gly Ile Thr Thr Ile Glu Ala Val Lys Arg Lys Ile Gln Val 
1               5                   10                  15      


Leu Gln Gln Gln Ala Asp Asp Ala Glu Glu Arg Ala Glu Arg Leu Gln 
            20                  25                  30          


Arg Glu Val Glu Gly Glu Arg Arg Ala Arg Glu Gln Ala Glu Ala Glu 
        35                  40                  45              


Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu Glu Glu Leu Asp 
    50                  55                  60                  


Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys Leu Glu Glu Ala 
65                  70                  75                  80  


Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys Val Ile Glu Asn 
                85                  90                  95      


Arg Ala Leu Lys Asp Glu Glu Lys Met Glu Leu Gln Glu Ile Gln Leu 
            100                 105                 110         


Lys Glu Ala Lys His Ile Ala Glu Glu Ala Asp Arg Lys Tyr Glu Glu 
        115                 120                 125             


Val Ala Arg Lys Leu Val Ile Ile Glu Gly Asp Leu Glu Arg Thr Glu 
    130                 135                 140                 


Glu Arg Ala Glu Leu Ala Glu Ser Arg Cys Arg Glu Met Asp Glu Gln 
145                 150                 155                 160 


Ile Arg Leu Met Asp Gln Asn Leu Lys Cys Leu Ser Ala Ala Glu Glu 
                165                 170                 175     


Lys Ala Glu Thr Arg Ala Glu Phe Ala Glu Arg Ser Val Ala Lys Leu 
            180                 185                 190         


Glu Lys Thr Ile Asp Asp Leu Glu Asp Lys Leu Lys Cys Thr Lys Glu 
        195                 200                 205             


Glu His Leu Cys Thr Gln Arg Met Leu Asp Gln Thr Leu Leu Asp Leu 
    210                 215                 220                 


Asn Glu Met 
225         

<210>  962
<211>  3291
<212>  DNA
<213>  Homo sapiens

<400>  962
gtcacatccg ggcgggttgg tgagttccgg tatttcaggg cgtagcaggc ggaagtaagg     60

gtgagaggag gctgcaacgc cgagcggagg aggcaggaac cggagcgcga gcagtagctg    120

ggtgggcacc atggctggga tcaccaccat cgaggcggtg aagcgcaaga tccaggttct    180

gcagcagcag gcagatgatg cagaggagcg agctgagcgc ctccagcgag aagttgaggg    240

agaaaggcgg gcccgggaac aggctgaggc tgaggtggcc tccttgaacc gtaggatcca    300

gctggttgaa gaagagctgg accgtgctca ggagcgcctg gccactgccc tgcaaaagct    360

ggaagaagct gaaaaagctg ctgatgagag tgagagaggt atgaaggtta ttgaaaaccg    420

ggccttaaaa gatgaagaaa agatggaact ccaggaaatc caactcaaag aagctaagca    480

cattgcagaa gaggcagata ggaagtatga agaggtggct cgtaagttgg tgatcattga    540

aggagacttg gaacgcacag aggaacgagc tgagctggca gagtcccgtt gccgagagat    600

ggatgagcag attagactga tggaccagaa cctgaagtgt ctgagtgctg ctgaagaaaa    660

gtactctcaa aaagaagata aatatgagga agaaatcaag attcttactg ataaactcaa    720

ggaggcagag acccgtgctg agtttgctga gagatcggta gccaagctgg aaaagacaat    780

tgatgacctg gaagatgagc tctatgccca gaaactgaag tacaaggcca ttagcgagga    840

gctggaccac gccctcaatg acatgacctc tatataaact gaaatgcacc aaagaggagc    900

acctctgtac acaaaggatg ctggaccaga ccctgcttga cctgaatgag atgtagaacg    960

ccccagtccc accctgctgc tgctcctccc tctgacccag actccgcctg aggccagcct   1020

gcgggaagct gacctttaac tgagggctga tctttaactg gaaggctgct ttctcctttc   1080

accaccccct ccttccctgt gtctttttcg ccaaactgtc tctgcctctt cccggagaat   1140

ccagctgggc tagaggctga gcacctttgg aaacaacatt taagggaatg tgagcacaat   1200

gcataatgtc tttaaaaagc atgttgtgat gtacacattt tgtaattacc ttttttgttg   1260

ttttgtagca accatttgta aaacattcca aataattcca cagtcctgaa gcagcaatcg   1320

aatccctttc tcacttttgg aaggtgactt ttcaccttaa tgcatattcc cctctccata   1380

gaggagagga aaaggtgtag gcctgcctta ccgagagcca aacagagccc agggagactc   1440

cgctgtggga aacctcattg ttctgtacaa agtactagct aaaccagaaa ggtgattcca   1500

ggaggagtta gccaaacaac aacaaaaaca aaaaatgtgc tgttcaagtt ttcagcttta   1560

agatatcttt ggataatgtt atttctattt tttatttttt tcattagaag ttaccaaatt   1620

aagatggtaa gacctctgag accaaaattt tgtcccatct ctaccccctc acaactgctt   1680

acagaatgga tcatgtcccc cttatgttga ggtgaccact taattgcttt cctgcctcct   1740

tgaaagaaag aaagaaagaa gactgtgttt ttgccactga tttagccatg tgaaactcat   1800

ctcattaccc ttttctgggt ttgaagctgc tgtctctaga agtgccatct caattgtgct   1860

ttgtatcagt cagtgctgga gaaatcttga atagcttatg tacaaaactt tttaaatttt   1920

atattatttt gaaactttgc tttgggtttg tggcaccctg gccaccccat ctggctgtga   1980

cagcctctgc agtccgtggg ctggcagttt gttgatcttt taagtttcct tccctaccca   2040

gtccccattt tctggtaagg tttctaggag gtctgttagg tgtacatcct gcagcttatt   2100

ggcttaaaat gtactctcct tttatgtggt ctctttgggg ccgattggga gaaagagaaa   2160

tcaatagtgc aactgttttg atactgaata ttgacaagtg tctttttgaa ataaagaacc   2220

agtccctcca accctcagac ctatttgact tttatttatt aaaactaaat gtgctttctc   2280

cacagaagct atgaggtttg ggttaaaaat agcatctttg tgggtggtag caacaggatt   2340

tattctttat tattattatt tttgagatga agtttcattc ttgttgcctg ggctggagcg   2400

taatggctcg atctcggctc actgcaacct ccgcctcctg gttcaagaga ttctcctgcc   2460

tcagcctccc gagtagctgg gattacaggc acctgccacc atgcccgggt aattttttat   2520

attttaagta gagacagggc ttcaccatgt tggccaggct ggtctcgaac tcctgacctt   2580

caggtgatcc acctgcctca gcttcccaaa atgctgggat tacgggcgtg agccaccgca   2640

cccagctgga gcaacaggat ttaatataga gcaaatgttt agttttatca tctgtaaaat   2700

ggagataagt attgtcagag taaacatgaa gattagaaag aacacttaat gtgctgggcc   2760

ttttataggt taacactgac atctcaggct gaactatata cattttcctt cacaaccata   2820

tcaatcctta taaactatgg atttatgctc cttaaaacaa tatataatgc tgatcactac   2880

tataaatgcg tggttttaac caactgtact gaaacagctt tgagtttata ttctgtttgg   2940

atatttggag aaaacaacaa gtgctctcaa gagtatttgc ttagaggccg gctgtgtgag   3000

tggataactt tgaaagctgc ttttgagacg ccagtgtctg gcatttcctg cattctggcc   3060

tggaggccgg acgtgaatct gacttctagt aaaaatacac ggttcccttg acaaagtcga   3120

gctgtttatc ccagagactg cacaattttc cgttgatagg catggaccaa tgctaactgg   3180

aaatcattgc aaaaagtttt tttgtcgggc ggagggtgtg gtgttaagat aaacagtgtg   3240

caacagaaga aattaaaact ggaagaaatt aaagggtttt ttttagactt t            3291


<210>  963
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  963


Met Ala Gly Ile Thr Thr Ile Glu Ala Val Lys Arg Lys Ile Gln Val 
1               5                   10                  15      


Leu Gln Gln Gln Ala Asp Asp Ala Glu Glu Arg Ala Glu Arg Leu Gln 
            20                  25                  30          


Arg Glu Val Glu Gly Glu Arg Arg Ala Arg Glu Gln Ala Glu Ala Glu 
        35                  40                  45              


Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu Glu Glu Leu Asp 
    50                  55                  60                  


Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys Leu Glu Glu Ala 
65                  70                  75                  80  


Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys Val Ile Glu Asn 
                85                  90                  95      


Arg Ala Leu Lys Asp Glu Glu Lys Met Glu Leu Gln Glu Ile Gln Leu 
            100                 105                 110         


Lys Glu Ala Lys His Ile Ala Glu Glu Ala Asp Arg Lys Tyr Glu Glu 
        115                 120                 125             


Val Ala Arg Lys Leu Val Ile Ile Glu Gly Asp Leu Glu Arg Thr Glu 
    130                 135                 140                 


Glu Arg Ala Glu Leu Ala Glu Ser Arg Cys Arg Glu Met Asp Glu Gln 
145                 150                 155                 160 


Ile Arg Leu Met Asp Gln Asn Leu Lys Cys Leu Ser Ala Ala Glu Glu 
                165                 170                 175     


Lys Tyr Ser Gln Lys Glu Asp Lys Tyr Glu Glu Glu Ile Lys Ile Leu 
            180                 185                 190         


Thr Asp Lys Leu Lys Glu Ala Glu Thr Arg Ala Glu Phe Ala Glu Arg 
        195                 200                 205             


Ser Val Ala Lys Leu Glu Lys Thr Ile Asp Asp Leu Glu Asp Glu Leu 
    210                 215                 220                 


Tyr Ala Gln Lys Leu Lys Tyr Lys Ala Ile Ser Glu Glu Leu Asp His 
225                 230                 235                 240 


Ala Leu Asn Asp Met Thr Ser Ile 
                245             

<210>  964
<211>  3212
<212>  DNA
<213>  Homo sapiens

<400>  964
gtcacatccg ggcgggttgg tgagttccgg tatttcaggg cgtagcaggc ggaagtaagg     60

gtgagaggag gctgcaacgc cgagcggagg aggcaggaac cggagcgcga gcagtagctg    120

ggtgggcacc atggctggga tcaccaccat cgaggcggtg aagcgcaaga tccaggttct    180

gcagcagcag gcagatgatg cagaggagcg agctgagcgc ctccagcgag aagttgaggg    240

agaaaggcgg gcccgggaac aggctgaggc tgaggtggcc tccttgaacc gtaggatcca    300

gctggttgaa gaagagctgg accgtgctca ggagcgcctg gccactgccc tgcaaaagct    360

ggaagaagct gaaaaagctg ctgatgagag tgagagaggt atgaaggtta ttgaaaaccg    420

ggccttaaaa gatgaagaaa agatggaact ccaggaaatc caactcaaag aagctaagca    480

cattgcagaa gaggcagata ggaagtatga agaggtggct cgtaagttgg tgatcattga    540

aggagacttg gaacgcacag aggaacgagc tgagctggca gagtcccgtt gccgagagat    600

ggatgagcag attagactga tggaccagaa cctgaagtgt ctgagtgctg ctgaagaaaa    660

gtactctcaa aaagaagata aatatgagga agaaatcaag attcttactg ataaactcaa    720

ggaggcagag acccgtgctg agtttgctga gagatcggta gccaagctgg aaaagacaat    780

tgatgacctg gaagataaac tgaaatgcac caaagaggag cacctctgta cacaaaggat    840

gctggaccag accctgcttg acctgaatga gatgtagaac gccccagtcc caccctgctg    900

ctgctcctcc ctctgaccca gactccgcct gaggccagcc tgcgggaagc tgacctttaa    960

ctgagggctg atctttaact ggaaggctgc tttctccttt caccaccccc tccttccctg   1020

tgtctttttc gccaaactgt ctctgcctct tcccggagaa tccagctggg ctagaggctg   1080

agcacctttg gaaacaacat ttaagggaat gtgagcacaa tgcataatgt ctttaaaaag   1140

catgttgtga tgtacacatt ttgtaattac cttttttgtt gttttgtagc aaccatttgt   1200

aaaacattcc aaataattcc acagtcctga agcagcaatc gaatcccttt ctcacttttg   1260

gaaggtgact tttcacctta atgcatattc ccctctccat agaggagagg aaaaggtgta   1320

ggcctgcctt accgagagcc aaacagagcc cagggagact ccgctgtggg aaacctcatt   1380

gttctgtaca aagtactagc taaaccagaa aggtgattcc aggaggagtt agccaaacaa   1440

caacaaaaac aaaaaatgtg ctgttcaagt tttcagcttt aagatatctt tggataatgt   1500

tatttctatt ttttattttt ttcattagaa gttaccaaat taagatggta agacctctga   1560

gaccaaaatt ttgtcccatc tctaccccct cacaactgct tacagaatgg atcatgtccc   1620

ccttatgttg aggtgaccac ttaattgctt tcctgcctcc ttgaaagaaa gaaagaaaga   1680

agactgtgtt tttgccactg atttagccat gtgaaactca tctcattacc cttttctggg   1740

tttgaagctg ctgtctctag aagtgccatc tcaattgtgc tttgtatcag tcagtgctgg   1800

agaaatcttg aatagcttat gtacaaaact ttttaaattt tatattattt tgaaactttg   1860

ctttgggttt gtggcaccct ggccacccca tctggctgtg acagcctctg cagtccgtgg   1920

gctggcagtt tgttgatctt ttaagtttcc ttccctaccc agtccccatt ttctggtaag   1980

gtttctagga ggtctgttag gtgtacatcc tgcagcttat tggcttaaaa tgtactctcc   2040

ttttatgtgg tctctttggg gccgattggg agaaagagaa atcaatagtg caactgtttt   2100

gatactgaat attgacaagt gtctttttga aataaagaac cagtccctcc aaccctcaga   2160

cctatttgac ttttatttat taaaactaaa tgtgctttct ccacagaagc tatgaggttt   2220

gggttaaaaa tagcatcttt gtgggtggta gcaacaggat ttattcttta ttattattat   2280

ttttgagatg aagtttcatt cttgttgcct gggctggagc gtaatggctc gatctcggct   2340

cactgcaacc tccgcctcct ggttcaagag attctcctgc ctcagcctcc cgagtagctg   2400

ggattacagg cacctgccac catgcccggg taatttttta tattttaagt agagacaggg   2460

cttcaccatg ttggccaggc tggtctcgaa ctcctgacct tcaggtgatc cacctgcctc   2520

agcttcccaa aatgctggga ttacgggcgt gagccaccgc acccagctgg agcaacagga   2580

tttaatatag agcaaatgtt tagttttatc atctgtaaaa tggagataag tattgtcaga   2640

gtaaacatga agattagaaa gaacacttaa tgtgctgggc cttttatagg ttaacactga   2700

catctcaggc tgaactatat acattttcct tcacaaccat atcaatcctt ataaactatg   2760

gatttatgct ccttaaaaca atatataatg ctgatcacta ctataaatgc gtggttttaa   2820

ccaactgtac tgaaacagct ttgagtttat attctgtttg gatatttgga gaaaacaaca   2880

agtgctctca agagtatttg cttagaggcc ggctgtgtga gtggataact ttgaaagctg   2940

cttttgagac gccagtgtct ggcatttcct gcattctggc ctggaggccg gacgtgaatc   3000

tgacttctag taaaaataca cggttccctt gacaaagtcg agctgtttat cccagagact   3060

gcacaatttt ccgttgatag gcatggacca atgctaactg gaaatcattg caaaaagttt   3120

ttttgtcggg cggagggtgt ggtgttaaga taaacagtgt gcaacagaag aaattaaaac   3180

tggaagaaat taaagggttt tttttagact tt                                 3212


<210>  965
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  965


Met Ala Gly Ile Thr Thr Ile Glu Ala Val Lys Arg Lys Ile Gln Val 
1               5                   10                  15      


Leu Gln Gln Gln Ala Asp Asp Ala Glu Glu Arg Ala Glu Arg Leu Gln 
            20                  25                  30          


Arg Glu Val Glu Gly Glu Arg Arg Ala Arg Glu Gln Ala Glu Ala Glu 
        35                  40                  45              


Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu Glu Glu Leu Asp 
    50                  55                  60                  


Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys Leu Glu Glu Ala 
65                  70                  75                  80  


Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys Val Ile Glu Asn 
                85                  90                  95      


Arg Ala Leu Lys Asp Glu Glu Lys Met Glu Leu Gln Glu Ile Gln Leu 
            100                 105                 110         


Lys Glu Ala Lys His Ile Ala Glu Glu Ala Asp Arg Lys Tyr Glu Glu 
        115                 120                 125             


Val Ala Arg Lys Leu Val Ile Ile Glu Gly Asp Leu Glu Arg Thr Glu 
    130                 135                 140                 


Glu Arg Ala Glu Leu Ala Glu Ser Arg Cys Arg Glu Met Asp Glu Gln 
145                 150                 155                 160 


Ile Arg Leu Met Asp Gln Asn Leu Lys Cys Leu Ser Ala Ala Glu Glu 
                165                 170                 175     


Lys Tyr Ser Gln Lys Glu Asp Lys Tyr Glu Glu Glu Ile Lys Ile Leu 
            180                 185                 190         


Thr Asp Lys Leu Lys Glu Ala Glu Thr Arg Ala Glu Phe Ala Glu Arg 
        195                 200                 205             


Ser Val Ala Lys Leu Glu Lys Thr Ile Asp Asp Leu Glu Asp Lys Leu 
    210                 215                 220                 


Lys Cys Thr Lys Glu Glu His Leu Cys Thr Gln Arg Met Leu Asp Gln 
225                 230                 235                 240 


Thr Leu Leu Asp Leu Asn Glu Met 
                245             

<210>  966
<211>  2475
<212>  DNA
<213>  Homo sapiens

<400>  966
caggtagcag ttatgacttg ttcctggtag tggatttctc tcaagtgctt tattagtatt     60

caaacatttt tgagcccagg aaggtctagc tcctgacacg ttctatggta gagggaggag    120

ggttgatgct tgctcaggtt acttgggaac atctcttccc cagtatgcct tccaactctc    180

tctacatata ggttcaattc acgtctatgt gtctctctcc ctttttttat tctcttcctt    240

ttcccttttc ctctcctgtg gtatttaaaa tattcacagt aagtgttctg agctggagga    300

ggagctgaag aatgtcacca acaacctcaa gtctcttgag gctcaggcgg agaaggtagg    360

ggctggtttg tgaaagtgac aggctttggg gcctgggccc agccctgccc ttgatgaaag    420

actggagaca cgcattccat atataatcca gtgaggcgtg tcctcttcct acctccttac    480

catgtattca ggttctgggt ttaatgctat tttctgtgca ctttgattgc tttaattaaa    540

ataacttctt ggtctcaggt tactggagtc atgtgctcct taggctgata ctgctgtgct    600

gaaaagcaat aatcaagggc cctaacaggc tttctagcag acagatgggg gcaacagaca    660

gaatcagctc tgagacctaa tgagcaatca agacagatga cttcactttg ccatcatgtg    720

ggtgtgtttc agtcatgtga ccttggggtg ctactactct tgctcatcaa gcaggggaaa    780

ggaaaaacac ctccttgggt tgatctgaat aatatcaaag cttagatcca tcttaaaaag    840

tcatggagaa ttttaacctg aggatctcat ggctctaaag acatagattt ctgaatttca    900

aggacctatt gtccagagcc aggccttgct cttactcttg gaccattcag cacatttagt    960

gcaagaggat attcaattac tctcaaaaag aagataaata tgaggaagaa atcaagattc   1020

ttactgataa actcaaggag gcagagaccc gtgctgagtt tgctgagaga tcggtagcca   1080

agctggaaaa gacaattgat gacctggaag ataaactgaa atgcaccaaa gaggagcacc   1140

tctgtacaca aaggatgctg gaccagaccc tgcttgacct gaatgagatg tagaacgccc   1200

cagtcccacc ctgctgctgc tcctccctct gacccagact ccgcctgagg ccagcctgcg   1260

ggaagctgac ctttaactga gggctgatct ttaactggaa ggctgctttc tcctttcacc   1320

accccctcct tccctgtgtc tttttcgcca aactgtctct gcctcttccc ggagaatcca   1380

gctgggctag aggctgagca cctttggaaa caacatttaa gggaatgtga gcacaatgca   1440

taatgtcttt aaaaagcatg ttgtgatgta cacattttgt aattaccttt tttgttgttt   1500

tgtagcaacc atttgtaaaa cattccaaat aattccacag tcctgaagca gcaatcgaat   1560

ccctttctca cttttggaag gtgacttttc accttaatgc atattcccct ctccatagag   1620

gagaggaaaa ggtgtaggcc tgccttaccg agagccaaac agagcccagg gagactccgc   1680

tgtgggaaac ctcattgttc tgtacaaagt actagctaaa ccagaaaggt gattccagga   1740

ggagttagcc aaacaacaac aaaaacaaaa aatgtgctgt tcaagttttc agctttaaga   1800

tatctttgga taatgttatt tctatttttt atttttttca ttagaagtta ccaaattaag   1860

atggtaagac ctctgagacc aaaattttgt cccatctcta ccccctcaca actgcttaca   1920

gaatggatca tgtccccctt atgttgaggt gaccacttaa ttgctttcct gcctccttga   1980

aagaaagaaa gaaagaagac tgtgtttttg ccactgattt agccatgtga aactcatctc   2040

attacccttt tctgggtttg aagctgctgt ctctagaagt gccatctcaa ttgtgctttg   2100

tatcagtcag tgctggagaa atcttgaata gcttatgtac aaaacttttt aaattttata   2160

ttattttgaa actttgcttt gggtttgtgg caccctggcc accccatctg gctgtgacag   2220

cctctgcagt ccgtgggctg gcagtttgtt gatcttttaa gtttccttcc ctacccagtc   2280

cccattttct ggtaaggttt ctaggaggtc tgttaggtgt acatcctgca gcttattggc   2340

ttaaaatgta ctctcctttt atgtggtctc tttggggccg attgggagaa agagaaatca   2400

atagtgcaac tgttttgata ctgaatattg acaagtgtct ttttgaaata aagaaccagt   2460

ccctccaacc ctcag                                                    2475


<210>  967
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  967


Met Leu Phe Leu Phe Phe Ile Phe Phe Ile Arg Ser Tyr Gln Ile Lys 
1               5                   10                  15      


Met Val Arg Pro Leu Arg Pro Lys Phe Cys Pro Ile Ser Thr Pro Ser 
            20                  25                  30          


Gln Leu Leu Thr Glu Trp Ile Met Ser Pro Leu Cys 
        35                  40                  

<210>  968
<211>  3881
<212>  DNA
<213>  Homo sapiens

<400>  968
caggtagcag ttatgacttg ttcctggtag tggatttctc tcaagtgctt tattagtatt     60

caaacatttt tgagcccagg aaggtctagc tcctgacacg ttctatggta gagggaggag    120

ggttgatgct tgctcaggtt acttgggaac atctcttccc cagtatgcct tccaactctc    180

tctacatata ggttcaattc acgtctatgt gtctctctcc ctttttttat tctcttcctt    240

ttcccttttc ctctcctgtg gtatttaaaa tattcacagt aagtgttctg agctggagga    300

ggagctgaag aatgtcacca acaacctcaa gtctcttgag gctcaggcgg agaaggtagg    360

ggctggtttg tgaaagtgac aggctttggg gcctgggccc agccctgccc ttgatgaaag    420

actggagaca cgcattccat atataatcca gtgaggcgtg tcctcttcct acctccttac    480

catgtattca ggttctgggt ttaatgctat tttctgtgca ctttgattgc tttaattaaa    540

ataacttctt ggtctcaggt tactggagtc atgtgctcct taggctgata ctgctgtgct    600

gaaaagcaat aatcaagggc cctaacaggc tttctagcag acagatgggg gcaacagaca    660

gaatcagctc tgagacctaa tgagcaatca agacagatga cttcactttg ccatcatgtg    720

ggtgtgtttc agtcatgtga ccttggggtg ctactactct tgctcatcaa gcaggggaaa    780

ggaaaaacac ctccttgggt tgatctgaat aatatcaaag cttagatcca tcttaaaaag    840

tcatggagaa ttttaacctg aggatctcat ggctctaaag acatagattt ctgaatttca    900

aggacctatt gtccagagcc aggccttgct cttactcttg gaccattcag cacatttagt    960

gcaagaggat attcaatgta agttaaatgt agggaggggg gtattgcctg tgtgactaat   1020

ttctactctg aaatttttaa tctacttatc ttacagtact ctcaaaaaga agataaatat   1080

gaggaagaaa tcaagattct tactgataaa ctcaaggagg cagagacccg tgctgagttt   1140

gctgagagat cggtagccaa gctggaaaag acaattgatg acctggaaga gcgtctctac   1200

agccaacttg agcgaaaccg cctgctttct aatgagctga agctaacgct gcatgatctg   1260

tgtgactgat gggcagggct caatgatgcc cattaaactg agcttactgc tcacaccact   1320

gacctggacc ccaacaaaaa gctgattgtc tttttaaaag ttattatttt gccctgagca   1380

aattgcattt taattggggc agttagaatg ttgatttcct aacagcattg tgaagttgac   1440

cattgtgaag tttctgtccc tttagaagag attatgggtg aagaagggag gggcctgaga   1500

gattatagtg agaaaacttg cgagaatttt gttttccacc cttatttgct gctctttcac   1560

ttgggcactg actgtaggat atgttccctt gcatggatgt ttttaacaat aaaaggactg   1620

acttgacaag ttgttgtaac tgcttcatcg gcaggcccag gaatgggtcc ttctgactgg   1680

gtggaaaaaa gggaagtgaa agaaaagttg tgggatatga atatgggtct gtgttgccat   1740

caccttctct gagttgaaga tttgagtatt ttcctcacct ctttagagca gtcagagtgg   1800

tttgcttgct agacagatta gattctcctt aatgttcagc tgctgatttt ctttctgact   1860

tttgcgtcct ttttctggtt ttatgttaat ttcaagtaac tgtcacaagc tagttctgtt   1920

caatagctct gcagcaatct caaggtttgc ttacaactac ttgtttcagt agtattcttg   1980

gctttgtttt ctttagagat tatttgactt aactgtgagc gcccttttat ttatcccatc   2040

agttattact ttggcctcta ctttttcgaa aaaacatgta gtgcatgagg atcttcctgt   2100

gctctttata atctgagatt ctgatgtttc tattgtttgc aatgttcaaa ctccggtgag   2160

ccatttcaag agggtattgt tatgtgggca aaacctagaa aagtggatgg ctgatggtta   2220

aggcttgctc tttcattgac tgaaagctga aagtgttggt tgggtgtggg agggagagga   2280

aatggctgat aagggcccta actccctcac ccaggaagtg cagcaacacc tacaacttca   2340

gtaggcaagc caaaggccct acaaaactgg gtgatgtaat agctcacttc tgtggctgag   2400

aaggcagctg ctttatcagt ctgcagcttc tctgcaacag gagcaagtct caaagagcgg   2460

gtagaccttg aaatttactt ctagttcttg taacttctct cctttacccc cattagataa   2520

actgaaatgc accaaagagg agcacctctg tacacaaagg atgctggacc agaccctgct   2580

tgacctgaat gagatgtaga acgccccagt cccaccctgc tgctgctcct ccctctgacc   2640

cagactccgc ctgaggccag cctgcgggaa gctgaccttt aactgagggc tgatctttaa   2700

ctggaaggct gctttctcct ttcaccaccc cctccttccc tgtgtctttt tcgccaaact   2760

gtctctgcct cttcccggag aatccagctg ggctagaggc tgagcacctt tggaaacaac   2820

atttaaggga atgtgagcac aatgcataat gtctttaaaa agcatgttgt gatgtacaca   2880

ttttgtaatt accttttttg ttgttttgta gcaaccattt gtaaaacatt ccaaataatt   2940

ccacagtcct gaagcagcaa tcgaatccct ttctcacttt tggaaggtga cttttcacct   3000

taatgcatat tcccctctcc atagaggaga ggaaaaggtg taggcctgcc ttaccgagag   3060

ccaaacagag cccagggaga ctccgctgtg ggaaacctca ttgttctgta caaagtacta   3120

gctaaaccag aaaggtgatt ccaggaggag ttagccaaac aacaacaaaa acaaaaaatg   3180

tgctgttcaa gttttcagct ttaagatatc tttggataat gttatttcta ttttttattt   3240

ttttcattag aagttaccaa attaagatgg taagacctct gagaccaaaa ttttgtccca   3300

tctctacccc ctcacaactg cttacagaat ggatcatgtc ccccttatgt tgaggtgacc   3360

acttaattgc tttcctgcct ccttgaaaga aagaaagaaa gaagactgtg tttttgccac   3420

tgatttagcc atgtgaaact catctcatta cccttttctg ggtttgaagc tgctgtctct   3480

agaagtgcca tctcaattgt gctttgtatc agtcagtgct ggagaaatct tgaatagctt   3540

atgtacaaaa ctttttaaat tttatattat tttgaaactt tgctttgggt ttgtggcacc   3600

ctggccaccc catctggctg tgacagcctc tgcagtccgt gggctggcag tttgttgatc   3660

ttttaagttt ccttccctac ccagtcccca ttttctggta aggtttctag gaggtctgtt   3720

aggtgtacat cctgcagctt attggcttaa aatgtactct ccttttatgt ggtctctttg   3780

gggccgattg ggagaaagag aaatcaatag tgcaactgtt ttgatactga atattgacaa   3840

gtgtcttttt gaaataaaga accagtccct ccaaccctca g                       3881


<210>  969
<211>  50
<212>  PRT
<213>  Homo sapiens

<400>  969


Met Gly Glu Glu Gly Arg Gly Leu Arg Asp Tyr Ser Glu Lys Thr Cys 
1               5                   10                  15      


Glu Asn Phe Val Phe His Pro Tyr Leu Leu Leu Phe His Leu Gly Thr 
            20                  25                  30          


Asp Cys Arg Ile Cys Ser Leu Ala Trp Met Phe Leu Thr Ile Lys Gly 
        35                  40                  45              


Leu Thr 
    50  

<210>  970
<211>  2428
<212>  DNA
<213>  Homo sapiens

<400>  970
cattgaagga gacttggaac gcacagagga acgagctgag ctggcagagt cgtgagtatc     60

tagctcccca aatcttgtca ttaccaattt atcccttccc ctttggcttg ggcactaata    120

tgaataaatt agcattcctt caaccttgtt aaacagggcc tagggaatgg gagtcatcta    180

tagtgctttt ttaggcccaa gaatggtttt aggcttcctt attctcctga ctagtgacaa    240

gtgacaaaag aggctttctt attttttgtt ggtagggttt acaaattgag agcaaataag    300

gactaataca tggtgaacag ttaattggaa gatcctactg ggtccttcca cctggggtgg    360

aagacatcaa agtggctatc ctgatttaag atctagtgtc tggctgggtg tggtggctca    420

aacctgtagt cccagctact tagtatgcca aggcaggaag gttgcttgaa cccaggagtt    480

ggaggccagc ctgggcgtca tagggagacc ctgtccctaa aacaaataaa tttaaaaaaa    540

aaatctggtg tctgttttgg ccactttgcc aatctgctag ggaaccttag ggcaagggta    600

gatattaact gctctcccgt cggtaccttc tgggccttga ttaacaaagt cagtgctgaa    660

tgcatatgta tttgtgcttc cctcttacat tcccgtctgc cagacataac atatcatgac    720

catggtggtg ttctcttccc attttttgaa tttttttttt tcgttttgct gcttgttttc    780

ttgctgtgtt cctttttgac ctttctccct ccccacaacc tggcttgtgc catccccgtg    840

actatcacta acagccgttg ccgagagatg gatgagcaga ttagactgat ggaccagaac    900

ctgaagtgtc tgagtgctgc tgaagaaaag tactctcaaa aagaagataa atatgaggaa    960

gaaatcaaga ttcttactga taaactcaag gaggcagaga cccgtgctga gtttgctgag   1020

agatcggtag ccaagctgga aaagacaatt gatgacctgg aagataaact gaaatgcacc   1080

aaagaggagc acctctgtac acaaaggatg ctggaccaga ccctgcttga cctgaatgag   1140

atgtagaacg ccccagtccc accctgctgc tgctcctccc tctgacccag actccgcctg   1200

aggccagcct gcgggaagct gacctttaac tgagggctga tctttaactg gaaggctgct   1260

ttctcctttc accaccccct ccttccctgt gtctttttcg ccaaactgtc tctgcctctt   1320

cccggagaat ccagctgggc tagaggctga gcacctttgg aaacaacatt taagggaatg   1380

tgagcacaat gcataatgtc tttaaaaagc atgttgtgat gtacacattt tgtaattacc   1440

ttttttgttg ttttgtagca accatttgta aaacattcca aataattcca cagtcctgaa   1500

gcagcaatcg aatccctttc tcacttttgg aaggtgactt ttcaccttaa tgcatattcc   1560

cctctccata gaggagagga aaaggtgtag gcctgcctta ccgagagcca aacagagccc   1620

agggagactc cgctgtggga aacctcattg ttctgtacaa agtactagct aaaccagaaa   1680

ggtgattcca ggaggagtta gccaaacaac aacaaaaaca aaaaatgtgc tgttcaagtt   1740

ttcagcttta agatatcttt ggataatgtt atttctattt tttatttttt tcattagaag   1800

ttaccaaatt aagatggtaa gacctctgag accaaaattt tgtcccatct ctaccccctc   1860

acaactgctt acagaatgga tcatgtcccc cttatgttga ggtgaccact taattgcttt   1920

cctgcctcct tgaaagaaag aaagaaagaa gactgtgttt ttgccactga tttagccatg   1980

tgaaactcat ctcattaccc ttttctgggt ttgaagctgc tgtctctaga agtgccatct   2040

caattgtgct ttgtatcagt cagtgctgga gaaatcttga atagcttatg tacaaaactt   2100

tttaaatttt atattatttt gaaactttgc tttgggtttg tggcaccctg gccaccccat   2160

ctggctgtga cagcctctgc agtccgtggg ctggcagttt gttgatcttt taagtttcct   2220

tccctaccca gtccccattt tctggtaagg tttctaggag gtctgttagg tgtacatcct   2280

gcagcttatt ggcttaaaat gtactctcct tttatgtggt ctctttgggg ccgattggga   2340

gaaagagaaa tcaatagtgc aactgttttg atactgaata ttgacaagtg tctttttgaa   2400

ataaagaacc agtccctcca accctcag                                      2428


<210>  971
<211>  233
<212>  PRT
<213>  Homo sapiens

<400>  971


Met Pro Arg Gln Glu Gly Cys Leu Asn Pro Gly Val Gly Gly Gln Pro 
1               5                   10                  15      


Gly Arg His Arg Glu Thr Leu Ser Leu Lys Gln Ile Asn Leu Lys Lys 
            20                  25                  30          


Lys Ser Gly Val Cys Phe Gly His Phe Ala Asn Leu Leu Gly Asn Leu 
        35                  40                  45              


Arg Ala Arg Val Asp Ile Asn Cys Ser Pro Val Gly Thr Phe Trp Ala 
    50                  55                  60                  


Leu Ile Asn Lys Val Ser Ala Glu Cys Ile Cys Ile Cys Ala Ser Leu 
65                  70                  75                  80  


Leu His Ser Arg Leu Pro Asp Ile Thr Tyr His Asp His Gly Gly Val 
                85                  90                  95      


Leu Phe Pro Phe Phe Glu Phe Phe Phe Phe Val Leu Leu Leu Val Phe 
            100                 105                 110         


Leu Leu Cys Ser Phe Leu Thr Phe Leu Pro Pro His Asn Leu Ala Cys 
        115                 120                 125             


Ala Ile Pro Val Thr Ile Thr Asn Ser Arg Cys Arg Glu Met Asp Glu 
    130                 135                 140                 


Gln Ile Arg Leu Met Asp Gln Asn Leu Lys Cys Leu Ser Ala Ala Glu 
145                 150                 155                 160 


Glu Lys Tyr Ser Gln Lys Glu Asp Lys Tyr Glu Glu Glu Ile Lys Ile 
                165                 170                 175     


Leu Thr Asp Lys Leu Lys Glu Ala Glu Thr Arg Ala Glu Phe Ala Glu 
            180                 185                 190         


Arg Ser Val Ala Lys Leu Glu Lys Thr Ile Asp Asp Leu Glu Asp Lys 
        195                 200                 205             


Leu Lys Cys Thr Lys Glu Glu His Leu Cys Thr Gln Arg Met Leu Asp 
    210                 215                 220                 


Gln Thr Leu Leu Asp Leu Asn Glu Met 
225                 230             

<210>  972
<211>  1731
<212>  DNA
<213>  Homo sapiens

<400>  972
tgaagaggtg gctcgtaagt tggtgatcat tgaaggagac ttggaacgca cagaggaacg     60

agctgagctg gcagagtccc gttgccgaga gatggatgag cagattagac tgatggacca    120

gaacctgaag tgtctgagtg ctgctgaaga aaagtactct caaaaagaag ataaatatga    180

ggaagaaatc aagattctta ctgataaact caaggaggca gagacccgtg ctgagtttgc    240

tgagagatcg gtagccaagc tggaaaagac aattgatgac ctggaagatg agctctatgc    300

ccagaaactg aagtacaagg ccattagcga ggagctggac cacgccctca atgacatgac    360

ctctatataa actgaaatgc accaaagagg agcacctctg tacacaaagg atgctggacc    420

agaccctgct tgacctgaat gagatgtaga acgccccagt cccaccctgc tgctgctcct    480

ccctctgacc cagactccgc ctgaggccag cctgcgggaa gctgaccttt aactgagggc    540

tgatctttaa ctggaaggct gctttctcct ttcaccaccc cctccttccc tgtgtctttt    600

tcgccaaact gtctctgcct cttcccggag aatccagctg ggctagaggc tgagcacctt    660

tggaaacaac atttaaggga atgtgagcac aatgcataat gtctttaaaa agcatgttgt    720

gatgtacaca ttttgtaatt accttttttg ttgttttgta gcaaccattt gtaaaacatt    780

ccaaataatt ccacagtcct gaagcagcaa tcgaatccct ttctcacttt tggaaggtga    840

cttttcacct taatgcatat tcccctctcc atagaggaga ggaaaaggtg taggcctgcc    900

ttaccgagag ccaaacagag cccagggaga ctccgctgtg ggaaacctca ttgttctgta    960

caaagtacta gctaaaccag aaaggtgatt ccaggaggag ttagccaaac aacaacaaaa   1020

acaaaaaatg tgctgttcaa gttttcagct ttaagatatc tttggataat gttatttcta   1080

ttttttattt ttttcattag aagttaccaa attaagatgg taagacctct gagaccaaaa   1140

ttttgtccca tctctacccc ctcacaactg cttacagaat ggatcatgtc ccccttatgt   1200

tgaggtgacc acttaattgc tttcctgcct ccttgaaaga aagaaagaaa gaagactgtg   1260

tttttgccac tgatttagcc atgtgaaact catctcatta cccttttctg ggtttgaagc   1320

tgctgtctct agaagtgcca tctcaattgt gctttgtatc agtcagtgct ggagaaatct   1380

tgaatagctt atgtacaaaa ctttttaaat tttatattat tttgaaactt tgctttgggt   1440

ttgtggcacc ctggccaccc catctggctg tgacagcctc tgcagtccgt gggctggcag   1500

tttgttgatc ttttaagttt ccttccctac ccagtcccca ttttctggta aggtttctag   1560

gaggtctgtt aggtgtacat cctgcagctt attggcttaa aatgtactct ccttttatgt   1620

ggtctctttg gggccgattg ggagaaagag aaatcaatag tgcaactgtt ttgatactga   1680

atattgacaa gtgtcttttt gaaataaaga accagtccct ccaaccctca g            1731


<210>  973
<211>  92
<212>  PRT
<213>  Homo sapiens

<400>  973


Met Asp Glu Gln Ile Arg Leu Met Asp Gln Asn Leu Lys Cys Leu Ser 
1               5                   10                  15      


Ala Ala Glu Glu Lys Tyr Ser Gln Lys Glu Asp Lys Tyr Glu Glu Glu 
            20                  25                  30          


Ile Lys Ile Leu Thr Asp Lys Leu Lys Glu Ala Glu Thr Arg Ala Glu 
        35                  40                  45              


Phe Ala Glu Arg Ser Val Ala Lys Leu Glu Lys Thr Ile Asp Asp Leu 
    50                  55                  60                  


Glu Asp Glu Leu Tyr Ala Gln Lys Leu Lys Tyr Lys Ala Ile Ser Glu 
65                  70                  75                  80  


Glu Leu Asp His Ala Leu Asn Asp Met Thr Ser Ile 
                85                  90          

<210>  974
<211>  1900
<212>  DNA
<213>  Homo sapiens

<400>  974
caggctgagg ctgaggtggc ctccttgaac cgtaggatcc agctggttga agaagagctg     60

gaccgtgctc aggagcgcct ggccactgcc ctgcaaaagc tggaagaagc tgaaaaagct    120

gctgatgaga gtgagagagg tatgaaggtt attgaaaacc gggccttaaa agatgaagaa    180

aagatggaac tccaggaaat ccaactcaaa gaagctaagc acattgcaga agaggcagat    240

aggaagtatg aagaggtggc tcgtaagttg gtgatcattg aaggagactt ggaacgcaca    300

gaggaacgag ctgagctggc agagtcccgt tgccgagaga tggatgagca gattagactg    360

atggaccaga acctgaagtg tctgagtgct gctgaagaaa agtactctca aaaagaagat    420

aaatatgagg aagaaatcaa gattcttact gataaactca aggaggcaga gacccgtgct    480

gagtttgctg agagatcggt agccaagctg gaaaagacaa ttgatgacct ggaagataaa    540

ctgaaatgca ccaaagagga gcacctctgt acacaaagga tgctggacca gaccctgctt    600

gacctgaatg agatgtagaa cgccccagtc ccaccctgct gctgctcctc cctctgaccc    660

agactccgcc tgaggccagc ctgcgggaag ctgaccttta actgagggct gatctttaac    720

tggaaggctg ctttctcctt tcaccacccc ctccttccct gtgtcttttt cgccaaactg    780

tctctgcctc ttcccggaga atccagctgg gctagaggct gagcaccttt ggaaacaaca    840

tttaagggaa tgtgagcaca atgcataatg tctttaaaaa gcatgttgtg atgtacacat    900

tttgtaatta ccttttttgt tgttttgtag caaccatttg taaaacattc caaataattc    960

cacagtcctg aagcagcaat cgaatccctt tctcactttt ggaaggtgac ttttcacctt   1020

aatgcatatt cccctctcca tagaggagag gaaaaggtgt aggcctgcct taccgagagc   1080

caaacagagc ccagggagac tccgctgtgg gaaacctcat tgttctgtac aaagtactag   1140

ctaaaccaga aaggtgattc caggaggagt tagccaaaca acaacaaaaa caaaaaatgt   1200

gctgttcaag ttttcagctt taagatatct ttggataatg ttatttctat tttttatttt   1260

tttcattaga agttaccaaa ttaagatggt aagacctctg agaccaaaat tttgtcccat   1320

ctctaccccc tcacaactgc ttacagaatg gatcatgtcc cccttatgtt gaggtgacca   1380

cttaattgct ttcctgcctc cttgaaagaa agaaagaaag aagactgtgt ttttgccact   1440

gatttagcca tgtgaaactc atctcattac ccttttctgg gtttgaagct gctgtctcta   1500

gaagtgccat ctcaattgtg ctttgtatca gtcagtgctg gagaaatctt gaatagctta   1560

tgtacaaaac tttttaaatt ttatattatt ttgaaacttt gctttgggtt tgtggcaccc   1620

tggccacccc atctggctgt gacagcctct gcagtccgtg ggctggcagt ttgttgatct   1680

tttaagtttc cttccctacc cagtccccat tttctggtaa ggtttctagg aggtctgtta   1740

ggtgtacatc ctgcagctta ttggcttaaa atgtactctc cttttatgtg gtctctttgg   1800

ggccgattgg gagaaagaga aatcaatagt gcaactgttt tgatactgaa tattgacaag   1860

tgtctttttg aaataaagaa ccagtccctc caaccctcag                         1900


<210>  975
<211>  158
<212>  PRT
<213>  Homo sapiens

<400>  975


Met Lys Val Ile Glu Asn Arg Ala Leu Lys Asp Glu Glu Lys Met Glu 
1               5                   10                  15      


Leu Gln Glu Ile Gln Leu Lys Glu Ala Lys His Ile Ala Glu Glu Ala 
            20                  25                  30          


Asp Arg Lys Tyr Glu Glu Val Ala Arg Lys Leu Val Ile Ile Glu Gly 
        35                  40                  45              


Asp Leu Glu Arg Thr Glu Glu Arg Ala Glu Leu Ala Glu Ser Arg Cys 
    50                  55                  60                  


Arg Glu Met Asp Glu Gln Ile Arg Leu Met Asp Gln Asn Leu Lys Cys 
65                  70                  75                  80  


Leu Ser Ala Ala Glu Glu Lys Tyr Ser Gln Lys Glu Asp Lys Tyr Glu 
                85                  90                  95      


Glu Glu Ile Lys Ile Leu Thr Asp Lys Leu Lys Glu Ala Glu Thr Arg 
            100                 105                 110         


Ala Glu Phe Ala Glu Arg Ser Val Ala Lys Leu Glu Lys Thr Ile Asp 
        115                 120                 125             


Asp Leu Glu Asp Lys Leu Lys Cys Thr Lys Glu Glu His Leu Cys Thr 
    130                 135                 140                 


Gln Arg Met Leu Asp Gln Thr Leu Leu Asp Leu Asn Glu Met 
145                 150                 155             

<210>  976
<211>  2292
<212>  DNA
<213>  Homo sapiens

<400>  976
attgtaaaga gaactgatcc tctgtgctag gagaaaagag aaaggcaagg tcccattccc     60

taccactcca ccctggaggg ggtctctgaa gctttttcta ggactcccat ctcaggttct    120

gcttttgata caggcttgtt catgtgtgca tgctcttagg agggcaccaa gatgtgtttt    180

ccccctctcc cttttcagcc ttgctaagaa ttctattgta aatgctgatt tgtgggagaa    240

actgcctgag ccagcttgct gtcatggcaa ctgtacaccc ccgccccata gcctgttatc    300

ttctactcca gtttgggtaa ctactggtga gctgcatgat gtcttacatt tcatgagctt    360

cctctaaatc tagttgtatt tttcgtctga ggggggctga ggctgaggtg gcctccttga    420

accgtaggat ccagctggtt gaagaagagc tggaccgtgc tcaggagcgc ctggccactg    480

ccctgcaaaa gctggaagaa gctgaaaaag ctgctgatga gagtgagaga ggtatgaagg    540

ttattgaaaa ccgggcctta aaagatgaag aaaagatgga actccaggaa atccaactca    600

aagaagctaa gcacattgca gaagaggcag ataggaagta tgaagaggtg gctcgtaagt    660

tggtgatcat tgaaggagac ttggaacgca cagaggaacg agctgagctg gcagagtcta    720

agtgttctga gctggaggag gagctgaaga atgtcaccaa caacctcaag tctcttgagg    780

ctcaggcgga gaagtactct caaaaagaag ataaatatga ggaagaaatc aagattctta    840

ctgataaact caaggaggca gagacccgtg ctgagtttgc tgagagatcg gtagccaagc    900

tggaaaagac aattgatgac ctggaagata aactgaaatg caccaaagag gagcacctct    960

gtacacaaag gatgctggac cagaccctgc ttgacctgaa tgagatgtag aacgccccag   1020

tcccaccctg ctgctgctcc tccctctgac ccagactccg cctgaggcca gcctgcggga   1080

agctgacctt taactgaggg ctgatcttta actggaaggc tgctttctcc tttcaccacc   1140

ccctccttcc ctgtgtcttt ttcgccaaac tgtctctgcc tcttcccgga gaatccagct   1200

gggctagagg ctgagcacct ttggaaacaa catttaaggg aatgtgagca caatgcataa   1260

tgtctttaaa aagcatgttg tgatgtacac attttgtaat tacctttttt gttgttttgt   1320

agcaaccatt tgtaaaacat tccaaataat tccacagtcc tgaagcagca atcgaatccc   1380

tttctcactt ttggaaggtg acttttcacc ttaatgcata ttcccctctc catagaggag   1440

aggaaaaggt gtaggcctgc cttaccgaga gccaaacaga gcccagggag actccgctgt   1500

gggaaacctc attgttctgt acaaagtact agctaaacca gaaaggtgat tccaggagga   1560

gttagccaaa caacaacaaa aacaaaaaat gtgctgttca agttttcagc tttaagatat   1620

ctttggataa tgttatttct attttttatt tttttcatta gaagttacca aattaagatg   1680

gtaagacctc tgagaccaaa attttgtccc atctctaccc cctcacaact gcttacagaa   1740

tggatcatgt cccccttatg ttgaggtgac cacttaattg ctttcctgcc tccttgaaag   1800

aaagaaagaa agaagactgt gtttttgcca ctgatttagc catgtgaaac tcatctcatt   1860

acccttttct gggtttgaag ctgctgtctc tagaagtgcc atctcaattg tgctttgtat   1920

cagtcagtgc tggagaaatc ttgaatagct tatgtacaaa actttttaaa ttttatatta   1980

ttttgaaact ttgctttggg tttgtggcac cctggccacc ccatctggct gtgacagcct   2040

ctgcagtccg tgggctggca gtttgttgat cttttaagtt tccttcccta cccagtcccc   2100

attttctggt aaggtttcta ggaggtctgt taggtgtaca tcctgcagct tattggctta   2160

aaatgtactc tccttttatg tggtctcttt ggggccgatt gggagaaaga gaaatcaata   2220

gtgcaactgt tttgatactg aatattgaca agtgtctttt tgaaataaag aaccagtccc   2280

tccaaccctc ag                                                       2292


<210>  977
<211>  158
<212>  PRT
<213>  Homo sapiens

<400>  977


Met Lys Val Ile Glu Asn Arg Ala Leu Lys Asp Glu Glu Lys Met Glu 
1               5                   10                  15      


Leu Gln Glu Ile Gln Leu Lys Glu Ala Lys His Ile Ala Glu Glu Ala 
            20                  25                  30          


Asp Arg Lys Tyr Glu Glu Val Ala Arg Lys Leu Val Ile Ile Glu Gly 
        35                  40                  45              


Asp Leu Glu Arg Thr Glu Glu Arg Ala Glu Leu Ala Glu Ser Lys Cys 
    50                  55                  60                  


Ser Glu Leu Glu Glu Glu Leu Lys Asn Val Thr Asn Asn Leu Lys Ser 
65                  70                  75                  80  


Leu Glu Ala Gln Ala Glu Lys Tyr Ser Gln Lys Glu Asp Lys Tyr Glu 
                85                  90                  95      


Glu Glu Ile Lys Ile Leu Thr Asp Lys Leu Lys Glu Ala Glu Thr Arg 
            100                 105                 110         


Ala Glu Phe Ala Glu Arg Ser Val Ala Lys Leu Glu Lys Thr Ile Asp 
        115                 120                 125             


Asp Leu Glu Asp Lys Leu Lys Cys Thr Lys Glu Glu His Leu Cys Thr 
    130                 135                 140                 


Gln Arg Met Leu Asp Gln Thr Leu Leu Asp Leu Asn Glu Met 
145                 150                 155             

<210>  978
<211>  1954
<212>  DNA
<213>  Homo sapiens

<400>  978
gcacggtcct ctgaaggccg gcgggctcgg agatgaagtt gggatctcgg aggatgggct     60

gaggctgagg tggcctcctt gaaccgtagg atccagctgg ttgaagaaga gctggaccgt    120

gctcaggagc gcctggccac tgccctgcaa aagctggaag aagctgaaaa agctgctgat    180

gagagtgaga gaggtatgaa ggttattgaa aaccgggcct taaaagatga agaaaagatg    240

gaactccagg aaatccaact caaagaagct aagcacattg cagaagaggc agataggaag    300

tatgaagagg tggctcgtaa gttggtgatc attgaaggag acttggaacg cacagaggaa    360

cgagctgagc tggcagagtc ccgttgccga gagatggatg agcagattag actgatggac    420

cagaacctga agtgtctgag tgctgctgaa gaaaagtact ctcaaaaaga agataaatat    480

gaggaagaaa tcaagattct tactgataaa ctcaaggagg cagagacccg tgctgagttt    540

gctgagagat cggtagccaa gctggaaaag acaattgatg acctggaaga taaactgaaa    600

tgcaccaaag aggagcacct ctgtacacaa aggatgctgg accagaccct gcttgacctg    660

aatgagatgt agaacgcccc agtcccaccc tgctgctgct cctccctctg acccagactc    720

cgcctgaggc cagcctgcgg gaagctgacc tttaactgag ggctgatctt taactggaag    780

gctgctttct cctttcacca ccccctcctt ccctgtgtct ttttcgccaa actgtctctg    840

cctcttcccg gagaatccag ctgggctaga ggctgagcac ctttggaaac aacatttaag    900

ggaatgtgag cacaatgcat aatgtcttta aaaagcatgt tgtgatgtac acattttgta    960

attacctttt ttgttgtttt gtagcaacca tttgtaaaac attccaaata attccacagt   1020

cctgaagcag caatcgaatc cctttctcac ttttggaagg tgacttttca ccttaatgca   1080

tattcccctc tccatagagg agaggaaaag gtgtaggcct gccttaccga gagccaaaca   1140

gagcccaggg agactccgct gtgggaaacc tcattgttct gtacaaagta ctagctaaac   1200

cagaaaggtg attccaggag gagttagcca aacaacaaca aaaacaaaaa atgtgctgtt   1260

caagttttca gctttaagat atctttggat aatgttattt ctatttttta tttttttcat   1320

tagaagttac caaattaaga tggtaagacc tctgagacca aaattttgtc ccatctctac   1380

cccctcacaa ctgcttacag aatggatcat gtccccctta tgttgaggtg accacttaat   1440

tgctttcctg cctccttgaa agaaagaaag aaagaagact gtgtttttgc cactgattta   1500

gccatgtgaa actcatctca ttaccctttt ctgggtttga agctgctgtc tctagaagtg   1560

ccatctcaat tgtgctttgt atcagtcagt gctggagaaa tcttgaatag cttatgtaca   1620

aaacttttta aattttatat tattttgaaa ctttgctttg ggtttgtggc accctggcca   1680

ccccatctgg ctgtgacagc ctctgcagtc cgtgggctgg cagtttgttg atcttttaag   1740

tttccttccc tacccagtcc ccattttctg gtaaggtttc taggaggtct gttaggtgta   1800

catcctgcag cttattggct taaaatgtac tctcctttta tgtggtctct ttggggccga   1860

ttgggagaaa gagaaatcaa tagtgcaact gttttgatac tgaatattga caagtgtctt   1920

tttgaaataa agaaccagtc cctccaaccc tcag                               1954


<210>  979
<211>  158
<212>  PRT
<213>  Homo sapiens

<400>  979


Met Lys Val Ile Glu Asn Arg Ala Leu Lys Asp Glu Glu Lys Met Glu 
1               5                   10                  15      


Leu Gln Glu Ile Gln Leu Lys Glu Ala Lys His Ile Ala Glu Glu Ala 
            20                  25                  30          


Asp Arg Lys Tyr Glu Glu Val Ala Arg Lys Leu Val Ile Ile Glu Gly 
        35                  40                  45              


Asp Leu Glu Arg Thr Glu Glu Arg Ala Glu Leu Ala Glu Ser Arg Cys 
    50                  55                  60                  


Arg Glu Met Asp Glu Gln Ile Arg Leu Met Asp Gln Asn Leu Lys Cys 
65                  70                  75                  80  


Leu Ser Ala Ala Glu Glu Lys Tyr Ser Gln Lys Glu Asp Lys Tyr Glu 
                85                  90                  95      


Glu Glu Ile Lys Ile Leu Thr Asp Lys Leu Lys Glu Ala Glu Thr Arg 
            100                 105                 110         


Ala Glu Phe Ala Glu Arg Ser Val Ala Lys Leu Glu Lys Thr Ile Asp 
        115                 120                 125             


Asp Leu Glu Asp Lys Leu Lys Cys Thr Lys Glu Glu His Leu Cys Thr 
    130                 135                 140                 


Gln Arg Met Leu Asp Gln Thr Leu Leu Asp Leu Asn Glu Met 
145                 150                 155             

<210>  980
<211>  1319
<212>  DNA
<213>  Homo sapiens

<400>  980
ggcggaagta agggtgagag gaggctgcaa cgccgagcgg aggaggcagg aaccctgctg     60

ctgctcctcc ctctgaccca gactccgcct gaggccagcc tgcgggaagc tgacctttaa    120

ctgagggctg atctttaact ggaaggctgc tttctccttt caccaccccc tccttccctg    180

tgtctttttc gccaaactgt ctctgcctct tcccggagaa tccagctggg ctagaggctg    240

agcacctttg gaaacaacat ttaagggaat gtgagcacaa tgcataatgt ctttaaaaag    300

catgttgtga tgtacacatt ttgtaattac cttttttgtt gttttgtagc aaccatttgt    360

aaaacattcc aaataattcc acagtcctga agcagcaatc gaatcccttt ctcacttttg    420

gaaggtgact tttcacctta atgcatattc ccctctccat agaggagagg aaaaggtgta    480

ggcctgcctt accgagagcc aaacagagcc cagggagact ccgctgtggg aaacctcatt    540

gttctgtaca aagtactagc taaaccagaa aggtgattcc aggaggagtt agccaaacaa    600

caacaaaaac aaaaaatgtg ctgttcaagt tttcagcttt aagatatctt tggataatgt    660

tatttctatt ttttattttt ttcattagaa gttaccaaat taagatggta agacctctga    720

gaccaaaatt ttgtcccatc tctaccccct cacaactgct tacagaatgg atcatgtccc    780

ccttatgttg aggtgaccac ttaattgctt tcctgcctcc ttgaaagaaa gaaagaaaga    840

agactgtgtt tttgccactg atttagccat gtgaaactca tctcattacc cttttctggg    900

tttgaagctg ctgtctctag aagtgccatc tcaattgtgc tttgtatcag tcagtgctgg    960

agaaatcttg aatagcttat gtacaaaact ttttaaattt tatattattt tgaaactttg   1020

ctttgggttt gtggcaccct ggccacccca tctggctgtg acagcctctg cagtccgtgg   1080

gctggcagtt tgttgatctt ttaagtttcc ttccctaccc agtccccatt ttctggtaag   1140

gtttctagga ggtctgttag gtgtacatcc tgcagcttat tggcttaaaa tgtactctcc   1200

ttttatgtgg tctctttggg gccgattggg agaaagagaa atcaatagtg caactgtttt   1260

gatactgaat attgacaagt gtctttttga aataaagaac cagtccctcc aaccctcag    1319


<210>  981
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  981


Met Leu Phe Leu Phe Phe Ile Phe Phe Ile Arg Ser Tyr Gln Ile Lys 
1               5                   10                  15      


Met Val Arg Pro Leu Arg Pro Lys Phe Cys Pro Ile Ser Thr Pro Ser 
            20                  25                  30          


Gln Leu Leu Thr Glu Trp Ile Met Ser Pro Leu Cys 
        35                  40                  

<210>  982
<211>  1255
<212>  DNA
<213>  Homo sapiens

<400>  982
gcgtagcagg cggaagtaag ggtgagagga ggctgcaacg ccgagcggag gaggcaggaa     60

ccggagcgcg agcagtagct gggtgggcac catggctggg atcaccacca tcgaggcggt    120

gaagcgcaag atccaggttc tgcagcagca ggcagatgat gcagaggagc gagctgagca    180

cctttggaaa caacatttaa gggaatgtga gcacaatgca taatgtcttt aaaaagcatg    240

ttgtgatgta cacattttgt aattaccttt tttgttgttt tgtagcaacc atttgtaaaa    300

cattccaaat aattccacag tcctgaagca gcaatcgaat ccctttctca cttttggaag    360

gtgacttttc accttaatgc atattcccct ctccatagag gagaggaaaa ggtgtaggcc    420

tgccttaccg agagccaaac agagcccagg gagactccgc tgtgggaaac ctcattgttc    480

tgtacaaagt actagctaaa ccagaaaggt gattccagga ggagttagcc aaacaacaac    540

aaaaacaaaa aatgtgctgt tcaagttttc agctttaaga tatctttgga taatgttatt    600

tctatttttt atttttttca ttagaagtta ccaaattaag atggtaagac ctctgagacc    660

aaaattttgt cccatctcta ccccctcaca actgcttaca gaatggatca tgtccccctt    720

atgttgaggt gaccacttaa ttgctttcct gcctccttga aagaaagaaa gaaagaagac    780

tgtgtttttg ccactgattt agccatgtga aactcatctc attacccttt tctgggtttg    840

aagctgctgt ctctagaagt gccatctcaa ttgtgctttg tatcagtcag tgctggagaa    900

atcttgaata gcttatgtac aaaacttttt aaattttata ttattttgaa actttgcttt    960

gggtttgtgg caccctggcc accccatctg gctgtgacag cctctgcagt ccgtgggctg   1020

gcagtttgtt gatcttttaa gtttccttcc ctacccagtc cccattttct ggtaaggttt   1080

ctaggaggtc tgttaggtgt acatcctgca gcttattggc ttaaaatgta ctctcctttt   1140

atgtggtctc tttggggccg attgggagaa agagaaatca atagtgcaac tgttttgata   1200

ctgaatattg acaagtgtct ttttgaaata aagaaccagt ccctccaacc ctcag        1255


<210>  983
<211>  43
<212>  PRT
<213>  Homo sapiens

<400>  983


Met Ala Gly Ile Thr Thr Ile Glu Ala Val Lys Arg Lys Ile Gln Val 
1               5                   10                  15      


Leu Gln Gln Gln Ala Asp Asp Ala Glu Glu Arg Ala Glu His Leu Trp 
            20                  25                  30          


Lys Gln His Leu Arg Glu Cys Glu His Asn Ala 
        35                  40              

<210>  984
<211>  1648
<212>  DNA
<213>  Homo sapiens

<400>  984
agggcgtagc aggcggaagt aagggtgaga ggaggctgca acgccgagcg gaggaggcag     60

gaaccggagc gcgagcagta gctgggtggg caccatggct gggatcacca ccatcgaggc    120

ggtgaagcgc aagatccagg ttctgcagca gcaggcagat gatgcagagg agcgagctga    180

gcgcctccag cgagaagttg agggagaaag gcgggcccgg gaacaggctg aggctgaggt    240

ggcctccttg aaccgtagga tccagctggt tgaagaagag ctggaccgtg ctcaggagcg    300

cctggccact gccctgcaaa agctggaaga agctgaaaaa gctgctgatg agagtgagag    360

atgtagaacg ccccagtccc accctgctgc tgctcctccc tctgacccag actccgcctg    420

aggccagcct gcgggaagct gacctttaac tgagggctga tctttaactg gaaggctgct    480

ttctcctttc accaccccct ccttccctgt gtctttttcg ccaaactgtc tctgcctctt    540

cccggagaat ccagctgggc tagaggctga gcacctttgg aaacaacatt taagggaatg    600

tgagcacaat gcataatgtc tttaaaaagc atgttgtgat gtacacattt tgtaattacc    660

ttttttgttg ttttgtagca accatttgta aaacattcca aataattcca cagtcctgaa    720

gcagcaatcg aatccctttc tcacttttgg aaggtgactt ttcaccttaa tgcatattcc    780

cctctccata gaggagagga aaaggtgtag gcctgcctta ccgagagcca aacagagccc    840

agggagactc cgctgtggga aacctcattg ttctgtacaa agtactagct aaaccagaaa    900

ggtgattcca ggaggagtta gccaaacaac aacaaaaaca aaaaatgtgc tgttcaagtt    960

ttcagcttta agatatcttt ggataatgtt atttctattt tttatttttt tcattagaag   1020

ttaccaaatt aagatggtaa gacctctgag accaaaattt tgtcccatct ctaccccctc   1080

acaactgctt acagaatgga tcatgtcccc cttatgttga ggtgaccact taattgcttt   1140

cctgcctcct tgaaagaaag aaagaaagaa gactgtgttt ttgccactga tttagccatg   1200

tgaaactcat ctcattaccc ttttctgggt ttgaagctgc tgtctctaga agtgccatct   1260

caattgtgct ttgtatcagt cagtgctgga gaaatcttga atagcttatg tacaaaactt   1320

tttaaatttt atattatttt gaaactttgc tttgggtttg tggcaccctg gccaccccat   1380

ctggctgtga cagcctctgc agtccgtggg ctggcagttt gttgatcttt taagtttcct   1440

tccctaccca gtccccattt tctggtaagg tttctaggag gtctgttagg tgtacatcct   1500

gcagcttatt ggcttaaaat gtactctcct tttatgtggt ctctttgggg ccgattggga   1560

gaaagagaaa tcaatagtgc aactgttttg atactgaata ttgacaagtg tctttttgaa   1620

ataaagaacc agtccctcca accctcag                                      1648


<210>  985
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  985


Met Ala Gly Ile Thr Thr Ile Glu Ala Val Lys Arg Lys Ile Gln Val 
1               5                   10                  15      


Leu Gln Gln Gln Ala Asp Asp Ala Glu Glu Arg Ala Glu Arg Leu Gln 
            20                  25                  30          


Arg Glu Val Glu Gly Glu Arg Arg Ala Arg Glu Gln Ala Glu Ala Glu 
        35                  40                  45              


Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu Glu Glu Leu Asp 
    50                  55                  60                  


Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys Leu Glu Glu Ala 
65                  70                  75                  80  


Glu Lys Ala Ala Asp Glu Ser Glu Arg Cys Arg Thr Pro Gln Ser His 
                85                  90                  95      


Pro Ala Ala Ala Pro Pro Ser Asp Pro Asp Ser Ala 
            100                 105             

<210>  986
<211>  1685
<212>  DNA
<213>  Homo sapiens

<400>  986
agggcgtagc aggcggaagt aagggtgaga ggaggctgca acgccgagcg gaggaggcag     60

gaaccggagc gcgagcagta gctgggtggg caccatggct gggatcacca ccatcgaggc    120

ggtgaagcgc aagatccagg ttctgcagca gcaggcagat gatgcagagg agcgagctga    180

gcgcctccag cgagaagttg agggagaaag gcgggcccgg gaacaggctg aggctgaggt    240

ggcctccttg aaccgtagga tccagctggt tgaagaagag ctggaccgtg ctcaggagcg    300

cctggccact gccctgcaaa agctggaaga agctgaaaaa gctgctgatg agagtgagag    360

aggtatgaag gttattgaaa accgggcctt aaaagatgaa gaaaagatgg aactccagga    420

aatccaactc aaagaagcta agcacattgc agaagaggca gataggaagt atgaagaggt    480

ggctcgtaag ttgctgatct ttaactggaa ggctgctttc tcctttcacc accccctcct    540

tccctgtgtc tttttcgcca aactgtctct gcctcttccc ggagaatcca gctgggctag    600

aggctgagca cctttggaaa caacatttaa gggaatgtga gcacaatgca taatgtcttt    660

aaaaagcatg ttgtgatgta cacattttgt aattaccttt tttgttgttt tgtagcaacc    720

atttgtaaaa cattccaaat aattccacag tcctgaagca gcaatcgaat ccctttctca    780

cttttggaag gtgacttttc accttaatgc atattcccct ctccatagag gagaggaaaa    840

ggtgtaggcc tgccttaccg agagccaaac agagcccagg gagactccgc tgtgggaaac    900

ctcattgttc tgtacaaagt actagctaaa ccagaaaggt gattccagga ggagttagcc    960

aaacaacaac aaaaacaaaa aatgtgctgt tcaagttttc agctttaaga tatctttgga   1020

taatgttatt tctatttttt atttttttca ttagaagtta ccaaattaag atggtaagac   1080

ctctgagacc aaaattttgt cccatctcta ccccctcaca actgcttaca gaatggatca   1140

tgtccccctt atgttgaggt gaccacttaa ttgctttcct gcctccttga aagaaagaaa   1200

gaaagaagac tgtgtttttg ccactgattt agccatgtga aactcatctc attacccttt   1260

tctgggtttg aagctgctgt ctctagaagt gccatctcaa ttgtgctttg tatcagtcag   1320

tgctggagaa atcttgaata gcttatgtac aaaacttttt aaattttata ttattttgaa   1380

actttgcttt gggtttgtgg caccctggcc accccatctg gctgtgacag cctctgcagt   1440

ccgtgggctg gcagtttgtt gatcttttaa gtttccttcc ctacccagtc cccattttct   1500

ggtaaggttt ctaggaggtc tgttaggtgt acatcctgca gcttattggc ttaaaatgta   1560

ctctcctttt atgtggtctc tttggggccg attgggagaa agagaaatca atagtgcaac   1620

tgttttgata ctgaatattg acaagtgtct ttttgaaata aagaaccagt ccctccaacc   1680

ctcag                                                               1685


<210>  987
<211>  170
<212>  PRT
<213>  Homo sapiens

<400>  987


Met Ala Gly Ile Thr Thr Ile Glu Ala Val Lys Arg Lys Ile Gln Val 
1               5                   10                  15      


Leu Gln Gln Gln Ala Asp Asp Ala Glu Glu Arg Ala Glu Arg Leu Gln 
            20                  25                  30          


Arg Glu Val Glu Gly Glu Arg Arg Ala Arg Glu Gln Ala Glu Ala Glu 
        35                  40                  45              


Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu Glu Glu Leu Asp 
    50                  55                  60                  


Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys Leu Glu Glu Ala 
65                  70                  75                  80  


Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys Val Ile Glu Asn 
                85                  90                  95      


Arg Ala Leu Lys Asp Glu Glu Lys Met Glu Leu Gln Glu Ile Gln Leu 
            100                 105                 110         


Lys Glu Ala Lys His Ile Ala Glu Glu Ala Asp Arg Lys Tyr Glu Glu 
        115                 120                 125             


Val Ala Arg Lys Leu Leu Ile Phe Asn Trp Lys Ala Ala Phe Ser Phe 
    130                 135                 140                 


His His Pro Leu Leu Pro Cys Val Phe Phe Ala Lys Leu Ser Leu Pro 
145                 150                 155                 160 


Leu Pro Gly Glu Ser Ser Trp Ala Arg Gly 
                165                 170 

<210>  988
<211>  1337
<212>  DNA
<213>  Homo sapiens

<400>  988
agggcgtagc aggcggaagt aagggtgaga ggaggctgca acgccgagcg gaggaggcag     60

gaaccggagc gcgagcagta gctgggtggg caccatggct gggatcacca ccatcgaggc    120

ggtgaagcgc aagatccagg ttctgcagca gcaggcagat gatgcagagg agcgagctga    180

gcgccccctc cttccctgtg tctttttcgc caaactgtct ctgcctcttc ccggagaatc    240

cagctgggct agaggctgag cacctttgga aacaacattt aagggaatgt gagcacaatg    300

cataatgtct ttaaaaagca tgttgtgatg tacacatttt gtaattacct tttttgttgt    360

tttgtagcaa ccatttgtaa aacattccaa ataattccac agtcctgaag cagcaatcga    420

atccctttct cacttttgga aggtgacttt tcaccttaat gcatattccc ctctccatag    480

aggagaggaa aaggtgtagg cctgccttac cgagagccaa acagagccca gggagactcc    540

gctgtgggaa acctcattgt tctgtacaaa gtactagcta aaccagaaag gtgattccag    600

gaggagttag ccaaacaaca acaaaaacaa aaaatgtgct gttcaagttt tcagctttaa    660

gatatctttg gataatgtta tttctatttt ttattttttt cattagaagt taccaaatta    720

agatggtaag acctctgaga ccaaaatttt gtcccatctc taccccctca caactgctta    780

cagaatggat catgtccccc ttatgttgag gtgaccactt aattgctttc ctgcctcctt    840

gaaagaaaga aagaaagaag actgtgtttt tgccactgat ttagccatgt gaaactcatc    900

tcattaccct tttctgggtt tgaagctgct gtctctagaa gtgccatctc aattgtgctt    960

tgtatcagtc agtgctggag aaatcttgaa tagcttatgt acaaaacttt ttaaatttta   1020

tattattttg aaactttgct ttgggtttgt ggcaccctgg ccaccccatc tggctgtgac   1080

agcctctgca gtccgtgggc tggcagtttg ttgatctttt aagtttcctt ccctacccag   1140

tccccatttt ctggtaaggt ttctaggagg tctgttaggt gtacatcctg cagcttattg   1200

gcttaaaatg tactctcctt ttatgtggtc tctttggggc cgattgggag aaagagaaat   1260

caatagtgca actgttttga tactgaatat tgacaagtgt ctttttgaaa taaagaacca   1320

gtccctccaa ccctcag                                                  1337


<210>  989
<211>  54
<212>  PRT
<213>  Homo sapiens

<400>  989


Met Ala Gly Ile Thr Thr Ile Glu Ala Val Lys Arg Lys Ile Gln Val 
1               5                   10                  15      


Leu Gln Gln Gln Ala Asp Asp Ala Glu Glu Arg Ala Glu Arg Pro Leu 
            20                  25                  30          


Leu Pro Cys Val Phe Phe Ala Lys Leu Ser Leu Pro Leu Pro Gly Glu 
        35                  40                  45              


Ser Ser Trp Ala Arg Gly 
    50                  

<210>  990
<211>  1684
<212>  DNA
<213>  Homo sapiens

<400>  990
agggcgtagc aggcggaagt aagggtgaga ggaggctgca acgccgagcg gaggaggcag     60

gaaccggagc gcgagcagta gctgggtggg caccatggct gggatcacca ccatcgaggc    120

ggtgaagcgc aagatccagg ttctgcagca gcaggcagat gatgcagagg agcgagctga    180

gcgcctccag cgagaagttg agggagaaag gcgggcccgg gaacaggctg aggctgaggt    240

ggcctccttg aaccgtagga tccagctggt tgaagaagag ctggaccgtg ctcaggagcg    300

cctggccact gccctgcaaa agctggaaga agctgaaaaa gctgctgatg agagtgagag    360

gtgatgctgg accagaccct gcttgacctg aatgagatgt agaacgcccc agtcccaccc    420

tgctgctgct cctccctctg acccagactc cgcctgaggc cagcctgcgg gaagctgacc    480

tttaactgag ggctgatctt taactggaag gctgctttct cctttcacca ccccctcctt    540

ccctgtgtct ttttcgccaa actgtctctg cctcttcccg gagaatccag ctgggctaga    600

ggctgagcac ctttggaaac aacatttaag ggaatgtgag cacaatgcat aatgtcttta    660

aaaagcatgt tgtgatgtac acattttgta attacctttt ttgttgtttt gtagcaacca    720

tttgtaaaac attccaaata attccacagt cctgaagcag caatcgaatc cctttctcac    780

ttttggaagg tgacttttca ccttaatgca tattcccctc tccatagagg agaggaaaag    840

gtgtaggcct gccttaccga gagccaaaca gagcccaggg agactccgct gtgggaaacc    900

tcattgttct gtacaaagta ctagctaaac cagaaaggtg attccaggag gagttagcca    960

aacaacaaca aaaacaaaaa atgtgctgtt caagttttca gctttaagat atctttggat   1020

aatgttattt ctatttttta tttttttcat tagaagttac caaattaaga tggtaagacc   1080

tctgagacca aaattttgtc ccatctctac cccctcacaa ctgcttacag aatggatcat   1140

gtccccctta tgttgaggtg accacttaat tgctttcctg cctccttgaa agaaagaaag   1200

aaagaagact gtgtttttgc cactgattta gccatgtgaa actcatctca ttaccctttt   1260

ctgggtttga agctgctgtc tctagaagtg ccatctcaat tgtgctttgt atcagtcagt   1320

gctggagaaa tcttgaatag cttatgtaca aaacttttta aattttatat tattttgaaa   1380

ctttgctttg ggtttgtggc accctggcca ccccatctgg ctgtgacagc ctctgcagtc   1440

cgtgggctgg cagtttgttg atcttttaag tttccttccc tacccagtcc ccattttctg   1500

gtaaggtttc taggaggtct gttaggtgta catcctgcag cttattggct taaaatgtac   1560

tctcctttta tgtggtctct ttggggccga ttgggagaaa gagaaatcaa tagtgcaact   1620

gttttgatac tgaatattga caagtgtctt tttgaaataa agaaccagtc cctccaaccc   1680

tcag                                                                1684


<210>  991
<211>  89
<212>  PRT
<213>  Homo sapiens

<400>  991


Met Ala Gly Ile Thr Thr Ile Glu Ala Val Lys Arg Lys Ile Gln Val 
1               5                   10                  15      


Leu Gln Gln Gln Ala Asp Asp Ala Glu Glu Arg Ala Glu Arg Leu Gln 
            20                  25                  30          


Arg Glu Val Glu Gly Glu Arg Arg Ala Arg Glu Gln Ala Glu Ala Glu 
        35                  40                  45              


Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu Glu Glu Leu Asp 
    50                  55                  60                  


Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys Leu Glu Glu Ala 
65                  70                  75                  80  


Glu Lys Ala Ala Asp Glu Ser Glu Arg 
                85                  

<210>  992
<211>  928
<212>  DNA
<213>  Homo sapiens

<400>  992
agggcgtagc aggcggaagt aagggtgaga ggaggctgca acgccgagcg gaggaggcag     60

gaaccggagc gcgagcagta gctgggtggg caccatggct gggatcacca ccatcgaggc    120

ggtgaagcgc aagatccagg ttctgcagca gcaggcagat gatgcagagg agcgagctga    180

gcgcctccag cgagaagttg agggagaaag gcgggcccgg gaacaggctg aggctgaggt    240

ggcctccttg aaccgtagga tccagctggt tgaagaagag ctggaccgtg ctcaggagcg    300

cctggccact gccctgcaaa agctggaaga agctgaaaaa gctgctgatg agagtgagag    360

aggtatgaag gttattgaaa accgggcctt aaaagatgaa gaaaagatgg aactccagga    420

aatccaactc aaagaaaaag aaagaaagaa gactgtgttt ttgccactga tttagccatg    480

tgaaactcat ctcattaccc ttttctgggt ttgaagctgc tgtctctaga agtgccatct    540

caattgtgct ttgtatcagt cagtgctgga gaaatcttga atagcttatg tacaaaactt    600

tttaaatttt atattatttt gaaactttgc tttgggtttg tggcaccctg gccaccccat    660

ctggctgtga cagcctctgc agtccgtggg ctggcagttt gttgatcttt taagtttcct    720

tccctaccca gtccccattt tctggtaagg tttctaggag gtctgttagg tgtacatcct    780

gcagcttatt ggcttaaaat gtactctcct tttatgtggt ctctttgggg ccgattggga    840

gaaagagaaa tcaatagtgc aactgttttg atactgaata ttgacaagtg tctttttgaa    900

ataaagaacc agtccctcca accctcag                                       928


<210>  993
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  993


Met Ala Gly Ile Thr Thr Ile Glu Ala Val Lys Arg Lys Ile Gln Val 
1               5                   10                  15      


Leu Gln Gln Gln Ala Asp Asp Ala Glu Glu Arg Ala Glu Arg Leu Gln 
            20                  25                  30          


Arg Glu Val Glu Gly Glu Arg Arg Ala Arg Glu Gln Ala Glu Ala Glu 
        35                  40                  45              


Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu Glu Glu Leu Asp 
    50                  55                  60                  


Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys Leu Glu Glu Ala 
65                  70                  75                  80  


Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys Val Ile Glu Asn 
                85                  90                  95      


Arg Ala Leu Lys Asp Glu Glu Lys Met Glu Leu Gln Glu Ile Gln Leu 
            100                 105                 110         


Lys Glu Lys Glu Arg Lys Lys Thr Val Phe Leu Pro Leu Ile 
        115                 120                 125     

<210>  994
<211>  2123
<212>  DNA
<213>  Homo sapiens

<400>  994
agggcgtagc aggcggaagt aagggtgaga ggaggctgca acgccgagcg gaggaggcag     60

gaaccggagc gcgagcagta gctgggtggg caccatggct gggatcacca ccatcgaggc    120

ggtgaagcgc aagatccagg ttctgcagca gcaggcagat gatgcagagg agcgagctga    180

gcgcctccag cgagaagttg agggagaaag gcgggcccgg gaacaggctg aggctgaggt    240

ggcctccttg aaccgtagga tccagctggt tgaagaagag ctggaccgtg ctcaggagcg    300

cctggccact gccctgcaaa agctggaaga agctgaaaaa gctgctgatg agagtgagag    360

aggtatgaag gttattgaaa accgggcctt aaaagatgaa gaaaagatgg aactccagga    420

aatccaactc aaagaagcta agcacattgc agaagaggca gataggaagt atgaagaggt    480

ggctcgtaag ttggtgatca ttgaaggaga cttggaacgc acagaggaac gagctgagct    540

ggcagagtct aagtgttctg agctggagga ggagctgaag aatgtcacca acaacctcaa    600

gtctcttgag gctcaggcgg agaagtactc tcaaaaagaa gataaatatg aggaagaaat    660

caagattctt actgataaac tcaaggaggc agagacccgt gctgagtttg ctgagagatc    720

ggtagccaag ctggaaaaga caattgatga cctggaagat aaactgaaat gcaccaaaga    780

ggagcacctc tgtacacaaa ggatgctgga ccagaccctg cttgacctga atgagatgta    840

gaacgcccca gtcccaccct gctgctgctc ctccctctga cccagactcc gcctgaggcc    900

agcctgcggg aagctgacct ttaactgagg gctgatcttt aactggaagg ctgctttctc    960

ctttcaccac cccctccttc cctgtgtctt tttcgccaaa ctgtctctgc ctcttcccgg   1020

agaatccagc tgggctagag gctgagcacc tttggaaaca acatttaagg gaatgtgagc   1080

acaatgcata atgtctttaa aaagcatgtt gtgatgtaca cattttgtaa ttaccttttt   1140

tgttgttttg tagcaaccat ttgtaaaaca ttccaaataa ttccacagtc ctgaagcagc   1200

aatcgaatcc ctttctcact tttggaaggt gacttttcac cttaatgcat attcccctct   1260

ccatagagga gaggaaaagg tgtaggcctg ccttaccgag agccaaacag agcccaggga   1320

gactccgctg tgggaaacct cattgttctg tacaaagtac tagctaaacc agaaaggtga   1380

ttccaggagg agttagccaa acaacaacaa aaacaaaaaa tgtgctgttc aagttttcag   1440

ctttaagata tctttggata atgttatttc tattttttat ttttttcatt agaagttacc   1500

aaattaagat ggtaagacct ctgagaccaa aattttgtcc catctctacc ccctcacaac   1560

tgcttacaga atggatcatg tcccccttat gttgaggtga ccacttaatt gctttcctgc   1620

ctccttgaaa gaaagaaaga aagaagactg tgtttttgcc actgatttag ccatgtgaaa   1680

ctcatctcat tacccttttc tgggtttgaa gctgctgtct ctagaagtgc catctcaatt   1740

gtgctttgta tcagtcagtg ctggagaaat cttgaatagc ttatgtacaa aactttttaa   1800

attttatatt attttgaaac tttgctttgg gtttgtggca ccctggccac cccatctggc   1860

tgtgacagcc tctgcagtcc gtgggctggc agtttgttga tcttttaagt ttccttccct   1920

acccagtccc cattttctgg taaggtttct aggaggtctg ttaggtgtac atcctgcagc   1980

ttattggctt aaaatgtact ctccttttat gtggtctctt tggggccgat tgggagaaag   2040

agaaatcaat agtgcaactg ttttgatact gaatattgac aagtgtcttt ttgaaataaa   2100

gaaccagtcc ctccaaccct cag                                           2123


<210>  995
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  995


Met Ala Gly Ile Thr Thr Ile Glu Ala Val Lys Arg Lys Ile Gln Val 
1               5                   10                  15      


Leu Gln Gln Gln Ala Asp Asp Ala Glu Glu Arg Ala Glu Arg Leu Gln 
            20                  25                  30          


Arg Glu Val Glu Gly Glu Arg Arg Ala Arg Glu Gln Ala Glu Ala Glu 
        35                  40                  45              


Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu Glu Glu Leu Asp 
    50                  55                  60                  


Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys Leu Glu Glu Ala 
65                  70                  75                  80  


Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys Val Ile Glu Asn 
                85                  90                  95      


Arg Ala Leu Lys Asp Glu Glu Lys Met Glu Leu Gln Glu Ile Gln Leu 
            100                 105                 110         


Lys Glu Ala Lys His Ile Ala Glu Glu Ala Asp Arg Lys Tyr Glu Glu 
        115                 120                 125             


Val Ala Arg Lys Leu Val Ile Ile Glu Gly Asp Leu Glu Arg Thr Glu 
    130                 135                 140                 


Glu Arg Ala Glu Leu Ala Glu Ser Lys Cys Ser Glu Leu Glu Glu Glu 
145                 150                 155                 160 


Leu Lys Asn Val Thr Asn Asn Leu Lys Ser Leu Glu Ala Gln Ala Glu 
                165                 170                 175     


Lys Tyr Ser Gln Lys Glu Asp Lys Tyr Glu Glu Glu Ile Lys Ile Leu 
            180                 185                 190         


Thr Asp Lys Leu Lys Glu Ala Glu Thr Arg Ala Glu Phe Ala Glu Arg 
        195                 200                 205             


Ser Val Ala Lys Leu Glu Lys Thr Ile Asp Asp Leu Glu Asp Lys Leu 
    210                 215                 220                 


Lys Cys Thr Lys Glu Glu His Leu Cys Thr Gln Arg Met Leu Asp Gln 
225                 230                 235                 240 


Thr Leu Leu Asp Leu Asn Glu Met 
                245             

<210>  996
<211>  1428
<212>  DNA
<213>  Homo sapiens

<400>  996
agggcgtagc aggcggaagt aagggtgaga ggaggctgca acgccgagcg gaggaggcag     60

gaaccggagc gcgagcagta gctgggtggg caccatggct gggatcacca ccatcgaggc    120

ggtgaagcgc aagatccagg ttctgcagca gcaggcagat gatgcagagg agcgagctga    180

gcgcctccag cgagaagttg aggccagcct gcgggaagct gacctttaac tgagggctga    240

tctttaactg gaaggctgct ttctcctttc accaccccct ccttccctgt gtctttttcg    300

ccaaactgtc tctgcctctt cccggagaat ccagctgggc tagaggctga gcacctttgg    360

aaacaacatt taagggaatg tgagcacaat gcataatgtc tttaaaaagc atgttgtgat    420

gtacacattt tgtaattacc ttttttgttg ttttgtagca accatttgta aaacattcca    480

aataattcca cagtcctgaa gcagcaatcg aatccctttc tcacttttgg aaggtgactt    540

ttcaccttaa tgcatattcc cctctccata gaggagagga aaaggtgtag gcctgcctta    600

ccgagagcca aacagagccc agggagactc cgctgtggga aacctcattg ttctgtacaa    660

agtactagct aaaccagaaa ggtgattcca ggaggagtta gccaaacaac aacaaaaaca    720

aaaaatgtgc tgttcaagtt ttcagcttta agatatcttt ggataatgtt atttctattt    780

tttatttttt tcattagaag ttaccaaatt aagatggtaa gacctctgag accaaaattt    840

tgtcccatct ctaccccctc acaactgctt acagaatgga tcatgtcccc cttatgttga    900

ggtgaccact taattgcttt cctgcctcct tgaaagaaag aaagaaagaa gactgtgttt    960

ttgccactga tttagccatg tgaaactcat ctcattaccc ttttctgggt ttgaagctgc   1020

tgtctctaga agtgccatct caattgtgct ttgtatcagt cagtgctgga gaaatcttga   1080

atagcttatg tacaaaactt tttaaatttt atattatttt gaaactttgc tttgggtttg   1140

tggcaccctg gccaccccat ctggctgtga cagcctctgc agtccgtggg ctggcagttt   1200

gttgatcttt taagtttcct tccctaccca gtccccattt tctggtaagg tttctaggag   1260

gtctgttagg tgtacatcct gcagcttatt ggcttaaaat gtactctcct tttatgtggt   1320

ctctttgggg ccgattggga gaaagagaaa tcaatagtgc aactgttttg atactgaata   1380

ttgacaagtg tctttttgaa ataaagaacc agtccctcca accctcag                1428


<210>  997
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  997


Met Ala Gly Ile Thr Thr Ile Glu Ala Val Lys Arg Lys Ile Gln Val 
1               5                   10                  15      


Leu Gln Gln Gln Ala Asp Asp Ala Glu Glu Arg Ala Glu Arg Leu Gln 
            20                  25                  30          


Arg Glu Val Glu Ala Ser Leu Arg Glu Ala Asp Leu 
        35                  40                  

<210>  998
<211>  757
<212>  DNA
<213>  Homo sapiens

<400>  998
agggcgtagc aggcggaagt aagggtgaga ggaggctgca acgccgagcg gaggaggcag     60

gaaccggagc gcgagcagta gctgggtggg caccatggct gggatcacca ccatcgaggc    120

ggtgaagcgc aagatccagg ttctgcagca gcaggcagat gatgcagagg agcgagctga    180

gcgcctccag cgagaagttg agggagaaag gcgggcccgg gaacaggctg aggctgaggt    240

ggcctccttg aaccgtagga tccagctggt tgaagaagag ctggaccgtg ctcaggagcg    300

cctggccact gccctgcaaa agctggaaga agctgaaaaa gctgctgatg agagtgagag    360

aggtatgaag gttattgaaa accgggcctt aaaagatgaa aaatcttgaa tagcttatgt    420

acaaaacttt ttaaatttta tattattttg aaactttgct ttgggtttgt ggcaccctgg    480

ccaccccatc tggctgtgac agcctctgca gtccgtgggc tggcagtttg ttgatctttt    540

aagtttcctt ccctacccag tccccatttt ctggtaaggt ttctaggagg tctgttaggt    600

gtacatcctg cagcttattg gcttaaaatg tactctcctt ttatgtggtc tctttggggc    660

cgattgggag aaagagaaat caatagtgca actgttttga tactgaatat tgacaagtgt    720

ctttttgaaa taaagaacca gtccctccaa ccctcag                             757


<210>  999
<211>  104
<212>  PRT
<213>  Homo sapiens

<400>  999


Met Ala Gly Ile Thr Thr Ile Glu Ala Val Lys Arg Lys Ile Gln Val 
1               5                   10                  15      


Leu Gln Gln Gln Ala Asp Asp Ala Glu Glu Arg Ala Glu Arg Leu Gln 
            20                  25                  30          


Arg Glu Val Glu Gly Glu Arg Arg Ala Arg Glu Gln Ala Glu Ala Glu 
        35                  40                  45              


Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu Glu Glu Leu Asp 
    50                  55                  60                  


Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys Leu Glu Glu Ala 
65                  70                  75                  80  


Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys Val Ile Glu Asn 
                85                  90                  95      


Arg Ala Leu Lys Asp Glu Lys Ser 
            100                 

<210>  1000
<211>  1683
<212>  DNA
<213>  Homo sapiens

<400>  1000
agggcgtagc aggcggaagt aagggtgaga ggaggctgca acgccgagcg gaggaggcag     60

gaaccggagc gcgagcagta gctgggtggg caccatggct gggatcacca ccatcgaggc    120

ggtgaagcgc aagatccagg ttctgcagca gcaggcagat gatgcagagg agcgagctga    180

gcgcctccag cgagaagttg agggagaaag gcgggcccgg gaacaggctg aggctgaggt    240

ggcctccttg aaccgtagga tccagctggt tgaagaagag ctggaccgtg ctcaggagcg    300

cctggccact gccctgcaaa agctggaaga agctgaaaaa gctgctgatg agagtgagag    360

aggtatgaag gttattgaaa accgggcctt aaaagatgaa gaaaagatgg aactccagga    420

aatccaactc aaagaagcta agcacattgc agaagaggca gataggaagt atgaagagct    480

ttaactgagg gctgatcttt aactggaagg ctgctttctc ctttcaccac cccctccttc    540

cctgtgtctt tttcgccaaa ctgtctctgc ctcttcccgg agaatccagc tgggctagag    600

gctgagcacc tttggaaaca acatttaagg gaatgtgagc acaatgcata atgtctttaa    660

aaagcatgtt gtgatgtaca cattttgtaa ttaccttttt tgttgttttg tagcaaccat    720

ttgtaaaaca ttccaaataa ttccacagtc ctgaagcagc aatcgaatcc ctttctcact    780

tttggaaggt gacttttcac cttaatgcat attcccctct ccatagagga gaggaaaagg    840

tgtaggcctg ccttaccgag agccaaacag agcccaggga gactccgctg tgggaaacct    900

cattgttctg tacaaagtac tagctaaacc agaaaggtga ttccaggagg agttagccaa    960

acaacaacaa aaacaaaaaa tgtgctgttc aagttttcag ctttaagata tctttggata   1020

atgttatttc tattttttat ttttttcatt agaagttacc aaattaagat ggtaagacct   1080

ctgagaccaa aattttgtcc catctctacc ccctcacaac tgcttacaga atggatcatg   1140

tcccccttat gttgaggtga ccacttaatt gctttcctgc ctccttgaaa gaaagaaaga   1200

aagaagactg tgtttttgcc actgatttag ccatgtgaaa ctcatctcat tacccttttc   1260

tgggtttgaa gctgctgtct ctagaagtgc catctcaatt gtgctttgta tcagtcagtg   1320

ctggagaaat cttgaatagc ttatgtacaa aactttttaa attttatatt attttgaaac   1380

tttgctttgg gtttgtggca ccctggccac cccatctggc tgtgacagcc tctgcagtcc   1440

gtgggctggc agtttgttga tcttttaagt ttccttccct acccagtccc cattttctgg   1500

taaggtttct aggaggtctg ttaggtgtac atcctgcagc ttattggctt aaaatgtact   1560

ctccttttat gtggtctctt tggggccgat tgggagaaag agaaatcaat agtgcaactg   1620

ttttgatact gaatattgac aagtgtcttt ttgaaataaa gaaccagtcc ctccaaccct   1680

cag                                                                 1683


<210>  1001
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  1001


Met Ala Gly Ile Thr Thr Ile Glu Ala Val Lys Arg Lys Ile Gln Val 
1               5                   10                  15      


Leu Gln Gln Gln Ala Asp Asp Ala Glu Glu Arg Ala Glu Arg Leu Gln 
            20                  25                  30          


Arg Glu Val Glu Gly Glu Arg Arg Ala Arg Glu Gln Ala Glu Ala Glu 
        35                  40                  45              


Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu Glu Glu Leu Asp 
    50                  55                  60                  


Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys Leu Glu Glu Ala 
65                  70                  75                  80  


Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys Val Ile Glu Asn 
                85                  90                  95      


Arg Ala Leu Lys Asp Glu Glu Lys Met Glu Leu Gln Glu Ile Gln Leu 
            100                 105                 110         


Lys Glu Ala Lys His Ile Ala Glu Glu Ala Asp Arg Lys Tyr Glu Glu 
        115                 120                 125             


Leu 
    

<210>  1002
<211>  1743
<212>  DNA
<213>  Homo sapiens

<400>  1002
agggcgtagc aggcggaagt aagggtgaga ggaggctgca acgccgagcg gaggaggcag     60

gaaccggagc gcgagcagta gctgggtggg caccatggct gggatcacca ccatcgaggc    120

ggtgaagcgc aagatccagg ttctgcagca gcaggcagat gatgcagagg agcgagctga    180

gcgcctccag cgagaagttg agggagaaag gcgggcccgg gaacaggctg aggctgaggt    240

ggcctccttg aaccgtagga tccagctggt tgaagaagag ctggaccgtg ctcaggagcg    300

cctggccact gccctgcaaa agctggaaga agctgaaaaa gctgctgatg agagtgagag    360

aggtatgaag gttattgaaa accgggcctt aaaagatgaa gaaaagatgg aactccagga    420

aatccaactc aaagaagcta agcacattgc agaagaggca gataggaagt atgaagaggt    480

ggctcgtaag ttggtgatca ttgaaggaga cttggaacgc acagaggaac gagctgacct    540

ttaactgagg gctgatcttt aactggaagg ctgctttctc ctttcaccac cccctccttc    600

cctgtgtctt tttcgccaaa ctgtctctgc ctcttcccgg agaatccagc tgggctagag    660

gctgagcacc tttggaaaca acatttaagg gaatgtgagc acaatgcata atgtctttaa    720

aaagcatgtt gtgatgtaca cattttgtaa ttaccttttt tgttgttttg tagcaaccat    780

ttgtaaaaca ttccaaataa ttccacagtc ctgaagcagc aatcgaatcc ctttctcact    840

tttggaaggt gacttttcac cttaatgcat attcccctct ccatagagga gaggaaaagg    900

tgtaggcctg ccttaccgag agccaaacag agcccaggga gactccgctg tgggaaacct    960

cattgttctg tacaaagtac tagctaaacc agaaaggtga ttccaggagg agttagccaa   1020

acaacaacaa aaacaaaaaa tgtgctgttc aagttttcag ctttaagata tctttggata   1080

atgttatttc tattttttat ttttttcatt agaagttacc aaattaagat ggtaagacct   1140

ctgagaccaa aattttgtcc catctctacc ccctcacaac tgcttacaga atggatcatg   1200

tcccccttat gttgaggtga ccacttaatt gctttcctgc ctccttgaaa gaaagaaaga   1260

aagaagactg tgtttttgcc actgatttag ccatgtgaaa ctcatctcat tacccttttc   1320

tgggtttgaa gctgctgtct ctagaagtgc catctcaatt gtgctttgta tcagtcagtg   1380

ctggagaaat cttgaatagc ttatgtacaa aactttttaa attttatatt attttgaaac   1440

tttgctttgg gtttgtggca ccctggccac cccatctggc tgtgacagcc tctgcagtcc   1500

gtgggctggc agtttgttga tcttttaagt ttccttccct acccagtccc cattttctgg   1560

taaggtttct aggaggtctg ttaggtgtac atcctgcagc ttattggctt aaaatgtact   1620

ctccttttat gtggtctctt tggggccgat tgggagaaag agaaatcaat agtgcaactg   1680

ttttgatact gaatattgac aagtgtcttt ttgaaataaa gaaccagtcc ctccaaccct   1740

cag                                                                 1743


<210>  1003
<211>  149
<212>  PRT
<213>  Homo sapiens

<400>  1003


Met Ala Gly Ile Thr Thr Ile Glu Ala Val Lys Arg Lys Ile Gln Val 
1               5                   10                  15      


Leu Gln Gln Gln Ala Asp Asp Ala Glu Glu Arg Ala Glu Arg Leu Gln 
            20                  25                  30          


Arg Glu Val Glu Gly Glu Arg Arg Ala Arg Glu Gln Ala Glu Ala Glu 
        35                  40                  45              


Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu Glu Glu Leu Asp 
    50                  55                  60                  


Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys Leu Glu Glu Ala 
65                  70                  75                  80  


Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys Val Ile Glu Asn 
                85                  90                  95      


Arg Ala Leu Lys Asp Glu Glu Lys Met Glu Leu Gln Glu Ile Gln Leu 
            100                 105                 110         


Lys Glu Ala Lys His Ile Ala Glu Glu Ala Asp Arg Lys Tyr Glu Glu 
        115                 120                 125             


Val Ala Arg Lys Leu Val Ile Ile Glu Gly Asp Leu Glu Arg Thr Glu 
    130                 135                 140                 


Glu Arg Ala Asp Leu 
145                 

<210>  1004
<211>  2020
<212>  DNA
<213>  Homo sapiens

<400>  1004
agggcgtagc aggcggaagt aagggtgaga ggaggctgca acgccgagcg gaggaggcag     60

gaaccggagc gcgagcagta gctgggtggg caccatggct gggatcacca ccatcgaggc    120

ggtgaagcgc aagatccagg ttctgcagca gcaggcagat gatgcagagg agcgagctga    180

gcgcctccag cgagaagttg agggagaaag gcgggcccgg gaacaggctg aggctgaggt    240

ggcctccttg aaccgtagga tccagctggt tgaagaagag ctggaccgtg ctcaggagcg    300

cctggccact gccctgcaaa agctggaaga aaagctaagc acattgcaga agaggcagat    360

aggaagtatg aagaggtggc tcgtaagttg gtgatcattg aaggagactt ggaacgcaca    420

gaggaacgag ctgagctggc agagtcccgt tgccgagaga tggatgagca gattagactg    480

atggaccaga acctgaagtg tctgagtgct gctgaagaaa agtactctca aaaagaagat    540

aaatatgagg aagaaatcaa gattcttact gataaactca aggaggcaga gacccgtgct    600

gagtttgctg agagatcggt agccaagctg gaaaagacaa ttgatgacct ggaagataaa    660

ctgaaatgca ccaaagagga gcacctctgt acacaaagga tgctggacca gaccctgctt    720

gacctgaatg agatgtagaa cgccccagtc ccaccctgct gctgctcctc cctctgaccc    780

agactccgcc tgaggccagc ctgcgggaag ctgaccttta actgagggct gatctttaac    840

tggaaggctg ctttctcctt tcaccacccc ctccttccct gtgtcttttt cgccaaactg    900

tctctgcctc ttcccggaga atccagctgg gctagaggct gagcaccttt ggaaacaaca    960

tttaagggaa tgtgagcaca atgcataatg tctttaaaaa gcatgttgtg atgtacacat   1020

tttgtaatta ccttttttgt tgttttgtag caaccatttg taaaacattc caaataattc   1080

cacagtcctg aagcagcaat cgaatccctt tctcactttt ggaaggtgac ttttcacctt   1140

aatgcatatt cccctctcca tagaggagag gaaaaggtgt aggcctgcct taccgagagc   1200

caaacagagc ccagggagac tccgctgtgg gaaacctcat tgttctgtac aaagtactag   1260

ctaaaccaga aaggtgattc caggaggagt tagccaaaca acaacaaaaa caaaaaatgt   1320

gctgttcaag ttttcagctt taagatatct ttggataatg ttatttctat tttttatttt   1380

tttcattaga agttaccaaa ttaagatggt aagacctctg agaccaaaat tttgtcccat   1440

ctctaccccc tcacaactgc ttacagaatg gatcatgtcc cccttatgtt gaggtgacca   1500

cttaattgct ttcctgcctc cttgaaagaa agaaagaaag aagactgtgt ttttgccact   1560

gatttagcca tgtgaaactc atctcattac ccttttctgg gtttgaagct gctgtctcta   1620

gaagtgccat ctcaattgtg ctttgtatca gtcagtgctg gagaaatctt gaatagctta   1680

tgtacaaaac tttttaaatt ttatattatt ttgaaacttt gctttgggtt tgtggcaccc   1740

tggccacccc atctggctgt gacagcctct gcagtccgtg ggctggcagt ttgttgatct   1800

tttaagtttc cttccctacc cagtccccat tttctggtaa ggtttctagg aggtctgtta   1860

ggtgtacatc ctgcagctta ttggcttaaa atgtactctc cttttatgtg gtctctttgg   1920

ggccgattgg gagaaagaga aatcaatagt gcaactgttt tgatactgaa tattgacaag   1980

tgtctttttg aaataaagaa ccagtccctc caaccctcag                         2020


<210>  1005
<211>  99
<212>  PRT
<213>  Homo sapiens

<400>  1005


Met Ala Gly Ile Thr Thr Ile Glu Ala Val Lys Arg Lys Ile Gln Val 
1               5                   10                  15      


Leu Gln Gln Gln Ala Asp Asp Ala Glu Glu Arg Ala Glu Arg Leu Gln 
            20                  25                  30          


Arg Glu Val Glu Gly Glu Arg Arg Ala Arg Glu Gln Ala Glu Ala Glu 
        35                  40                  45              


Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu Glu Glu Leu Asp 
    50                  55                  60                  


Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys Leu Glu Glu Lys 
65                  70                  75                  80  


Leu Ser Thr Leu Gln Lys Arg Gln Ile Gly Ser Met Lys Arg Trp Leu 
                85                  90                  95      


Val Ser Trp 
            

<210>  1006
<211>  4109
<212>  DNA
<213>  Homo sapiens

<400>  1006
agggcgtagc aggcggaagt aagggtgaga ggaggctgca acgccgagcg gaggaggcag     60

gaaccggagc gcgagcagta gctgggtggg caccatggct gggatcacca ccatcgaggc    120

ggtgaagcgc aagatccagg ttctgcagca gcaggcagat gatgcagagg agcgagctga    180

gcgcctccag cgagaagttg agggagaaag gcgggcccgg gaacagaggt atgaaggtta    240

ttgaaaaccg ggccttaaaa gatgaagaaa agatggaact ccaggaaatc caactcaaag    300

aagctaagca cattgcagaa gaggcagata ggaagtatga agaggtggct cgtaagttgg    360

tgatcattga aggagacttg gaacgcacag aggaacgagc tgagctggca gagtcgtgag    420

tatctagctc cccaaatctt gtcattacca atttatccct tcccctttgg cttgggcact    480

aatatgaata aattagcatt ccttcaacct tgttaaacag ggcctaggga atgggagtca    540

tctatagtgc ttttttaggc ccaagaatgg ttttaggctt ccttattctc ctgactagtg    600

acaagtgaca aaagaggctt tcttattttt tgttggtagg gtttacaaat tgagagcaaa    660

taaggactaa tacatggtga acagttaatt ggaagatcct actgggtcct tccacctggg    720

gtggaagaca tcaaagtggc tatcctgatt taagatctag tgtctggctg ggtgtggtgg    780

ctcaaacctg tagtcccagc tacttagtat gccaaggcag gaaggttgct tgaacccagg    840

agttggaggc cagcctgggc gtcataggga gaccctgtcc ctaaaacaaa taaatttaaa    900

aaaaaaatct ggtgtctgtt ttggccactt tgccaatctg ctagggaacc ttagggcaag    960

ggtagatatt aactgctctc ccgtcggtac cttctgggcc ttgattaaca aagtcagtgc   1020

tgaatgcata tgtatttgtg cttccctctt acattcccgt ctgccagaca taacatatca   1080

tgaccatggt ggtgttctct tcccattttt tgaatttttt tttttcgttt tgctgcttgt   1140

tttcttgctg tgttcctttt tgacctttct ccctccccac aacctggctt gtgccatccc   1200

cgtgactatc actaacagcc gttgccgaga gatggatgag cagattagac tgatggacca   1260

gaacctgaag tgtctgagtg ctgctgaaga aaaggtacta accattaagc ccacagcaag   1320

gttatatatg tggtgtggtt ttgttttgtt ttgtttttgt tttgcagctg cctcccctcc   1380

acttgatttt gttgagtgct gtctcatctc ttcatggaat gctccattct tttccactta   1440

cttggcatct ttcatctctt ctttcctagt tgcttcactg cctctccaca gggtctcctt   1500

cctttgggtg atttggggga ctgtttgggt tgggcatttg ttcccacctc caccccaggt   1560

agcagttatg acttgttcct ggtagtggat ttctctcaag tgctttatta gtattcaaac   1620

atttttgagc ccaggaaggt ctagctcctg acacgttcta tggtagaggg aggagggttg   1680

atgcttgctc aggttacttg ggaacatctc ttccccagta tgccttccaa ctctctctac   1740

atataggttc aattcacgtc tatgtgtctc tctccctttt tttattctct tccttttccc   1800

ttttcctctc ctgtggtatt taaaatattc acagtaagtg ttctgagctg gaggaggagc   1860

tgaagaatgt caccaacaac ctcaagtctc ttgaggctca ggcggagaag gtaggggctg   1920

gtttgtgaaa gtgacaggct ttggggcctg ggcccagccc tgcccttgat gaaagactgg   1980

agacacgcat tccatatata atccagtgag gcgtgtcctc ttcctacctc cttaccatgt   2040

attcaggttc tgggtttaat gctattttct gtgcactttg attgctttaa ttaaaataac   2100

ttcttggtct caggttactg gagtcatgtg ctccttaggc tgatactgct gtgctgaaaa   2160

gcaataatca agggccctaa caggctttct agcagacaga tgggggcaac agacagaatc   2220

agctctgaga cctaatgagc aatcaagaca gatgacttca ctttgccatc atgtgggtgt   2280

gtttcagtca tgtgaccttg gggtgctact actcttgctc atcaagcagg ggaaaggaaa   2340

aacacctcct tgggttgatc tgaataatat caaagcttag atccatctta aaaagtcatg   2400

gagaatttta acctgaggat ctcatggctc taaagacata gatttctgaa tttcaaggac   2460

ctattgtcca gagccaggcc ttgctcttac tcttggacca ttcagcacat ttagtgcaag   2520

aggatattca atgtaagtta aatgtaggga ggggggtatt gcctgtgtga ctaatttcta   2580

ctctgaaatt tttaatctac ttatcttaca gtactctcaa aaagaagata aatatgagga   2640

agaaatcaag attcttactg ataaactcaa ggaggcagag acccgtgctg agtttgctga   2700

gagatcggta gccaagctgg aaaagacaat tgatgacctg gaagataaac tgaaatgcac   2760

caaagaggag cacctctgta cacaaaggat gctggaccag accctgcttg acctgaatga   2820

gatgtagaac gccccagtcc caccctgctg ctgctcctcc ctctgaccca gactccgcct   2880

gaggccagcc tgcgggaagc tgacctttaa ctgagggctg atctttaact ggaaggctgc   2940

tttctccttt caccaccccc tccttccctg tgtctttttc gccaaactgt ctctgcctct   3000

tcccggagaa tccagctggg ctagaggctg agcacctttg gaaacaacat ttaagggaat   3060

gtgagcacaa tgcataatgt ctttaaaaag catgttgtga tgtacacatt ttgtaattac   3120

cttttttgtt gttttgtagc aaccatttgt aaaacattcc aaataattcc acagtcctga   3180

agcagcaatc gaatcccttt ctcacttttg gaaggtgact tttcacctta atgcatattc   3240

ccctctccat agaggagagg aaaaggtgta ggcctgcctt accgagagcc aaacagagcc   3300

cagggagact ccgctgtggg aaacctcatt gttctgtaca aagtactagc taaaccagaa   3360

aggtgattcc aggaggagtt agccaaacaa caacaaaaac aaaaaatgtg ctgttcaagt   3420

tttcagcttt aagatatctt tggataatgt tatttctatt ttttattttt ttcattagaa   3480

gttaccaaat taagatggta agacctctga gaccaaaatt ttgtcccatc tctaccccct   3540

cacaactgct tacagaatgg atcatgtccc ccttatgttg aggtgaccac ttaattgctt   3600

tcctgcctcc ttgaaagaaa gaaagaaaga agactgtgtt tttgccactg atttagccat   3660

gtgaaactca tctcattacc cttttctggg tttgaagctg ctgtctctag aagtgccatc   3720

tcaattgtgc tttgtatcag tcagtgctgg agaaatcttg aatagcttat gtacaaaact   3780

ttttaaattt tatattattt tgaaactttg ctttgggttt gtggcaccct ggccacccca   3840

tctggctgtg acagcctctg cagtccgtgg gctggcagtt tgttgatctt ttaagtttcc   3900

ttccctaccc agtccccatt ttctggtaag gtttctagga ggtctgttag gtgtacatcc   3960

tgcagcttat tggcttaaaa tgtactctcc ttttatgtgg tctctttggg gccgattggg   4020

agaaagagaa atcaatagtg caactgtttt gatactgaat attgacaagt gtctttttga   4080

aataaagaac cagtccctcc aaccctcag                                     4109


<210>  1007
<211>  86
<212>  PRT
<213>  Homo sapiens

<400>  1007


Met Met Gln Arg Ser Glu Leu Ser Ala Ser Ser Glu Lys Leu Arg Glu 
1               5                   10                  15      


Lys Gly Gly Pro Gly Asn Arg Gly Met Lys Val Ile Glu Asn Arg Ala 
            20                  25                  30          


Leu Lys Asp Glu Glu Lys Met Glu Leu Gln Glu Ile Gln Leu Lys Glu 
        35                  40                  45              


Ala Lys His Ile Ala Glu Glu Ala Asp Arg Lys Tyr Glu Glu Val Ala 
    50                  55                  60                  


Arg Lys Leu Val Ile Ile Glu Gly Asp Leu Glu Arg Thr Glu Glu Arg 
65                  70                  75                  80  


Ala Glu Leu Ala Glu Ser 
                85      

<210>  1008
<211>  2053
<212>  DNA
<213>  Homo sapiens

<400>  1008
agggcgtagc aggcggaagt aagggtgaga ggaggctgca acgccgagcg gaggaggcag     60

gaaccggagc gcgagcagta gctgggtggg caccatggct gggatcacca ccatcgaggc    120

ggtgaagcgc aagatccagg ttctgcagca gcaggcagat gatgcagagg agcgagctga    180

gcgcctccag cgagaagttg agggagaaag gcgggcccgg gaacaggctg aggctgaggt    240

ggcctccttg aaccgtagga tccagctggt tgaagaagag ctggaccgtg ctcaggagcg    300

cctggccact gccctgcaaa agctggaaga aaaaagatgg aactccagga aatccaactc    360

aaagaagcta agcacattgc agaagaggca gataggaagt atgaagaggt ggctcgtaag    420

ttggtgatca ttgaaggaga cttggaacgc acagaggaac gagctgagct ggcagagtcc    480

cgttgccgag agatggatga gcagattaga ctgatggacc agaacctgaa gtgtctgagt    540

gctgctgaag aaaagtactc tcaaaaagaa gataaatatg aggaagaaat caagattctt    600

actgataaac tcaaggaggc agagacccgt gctgagtttg ctgagagatc ggtagccaag    660

ctggaaaaga caattgatga cctggaagat aaactgaaat gcaccaaaga ggagcacctc    720

tgtacacaaa ggatgctgga ccagaccctg cttgacctga atgagatgta gaacgcccca    780

gtcccaccct gctgctgctc ctccctctga cccagactcc gcctgaggcc agcctgcggg    840

aagctgacct ttaactgagg gctgatcttt aactggaagg ctgctttctc ctttcaccac    900

cccctccttc cctgtgtctt tttcgccaaa ctgtctctgc ctcttcccgg agaatccagc    960

tgggctagag gctgagcacc tttggaaaca acatttaagg gaatgtgagc acaatgcata   1020

atgtctttaa aaagcatgtt gtgatgtaca cattttgtaa ttaccttttt tgttgttttg   1080

tagcaaccat ttgtaaaaca ttccaaataa ttccacagtc ctgaagcagc aatcgaatcc   1140

ctttctcact tttggaaggt gacttttcac cttaatgcat attcccctct ccatagagga   1200

gaggaaaagg tgtaggcctg ccttaccgag agccaaacag agcccaggga gactccgctg   1260

tgggaaacct cattgttctg tacaaagtac tagctaaacc agaaaggtga ttccaggagg   1320

agttagccaa acaacaacaa aaacaaaaaa tgtgctgttc aagttttcag ctttaagata   1380

tctttggata atgttatttc tattttttat ttttttcatt agaagttacc aaattaagat   1440

ggtaagacct ctgagaccaa aattttgtcc catctctacc ccctcacaac tgcttacaga   1500

atggatcatg tcccccttat gttgaggtga ccacttaatt gctttcctgc ctccttgaaa   1560

gaaagaaaga aagaagactg tgtttttgcc actgatttag ccatgtgaaa ctcatctcat   1620

tacccttttc tgggtttgaa gctgctgtct ctagaagtgc catctcaatt gtgctttgta   1680

tcagtcagtg ctggagaaat cttgaatagc ttatgtacaa aactttttaa attttatatt   1740

attttgaaac tttgctttgg gtttgtggca ccctggccac cccatctggc tgtgacagcc   1800

tctgcagtcc gtgggctggc agtttgttga tcttttaagt ttccttccct acccagtccc   1860

cattttctgg taaggtttct aggaggtctg ttaggtgtac atcctgcagc ttattggctt   1920

aaaatgtact ctccttttat gtggtctctt tggggccgat tgggagaaag agaaatcaat   1980

agtgcaactg ttttgatact gaatattgac aagtgtcttt ttgaaataaa gaaccagtcc   2040

ctccaaccct cag                                                      2053


<210>  1009
<211>  144
<212>  PRT
<213>  Homo sapiens

<400>  1009


Met Glu Leu Gln Glu Ile Gln Leu Lys Glu Ala Lys His Ile Ala Glu 
1               5                   10                  15      


Glu Ala Asp Arg Lys Tyr Glu Glu Val Ala Arg Lys Leu Val Ile Ile 
            20                  25                  30          


Glu Gly Asp Leu Glu Arg Thr Glu Glu Arg Ala Glu Leu Ala Glu Ser 
        35                  40                  45              


Arg Cys Arg Glu Met Asp Glu Gln Ile Arg Leu Met Asp Gln Asn Leu 
    50                  55                  60                  


Lys Cys Leu Ser Ala Ala Glu Glu Lys Tyr Ser Gln Lys Glu Asp Lys 
65                  70                  75                  80  


Tyr Glu Glu Glu Ile Lys Ile Leu Thr Asp Lys Leu Lys Glu Ala Glu 
                85                  90                  95      


Thr Arg Ala Glu Phe Ala Glu Arg Ser Val Ala Lys Leu Glu Lys Thr 
            100                 105                 110         


Ile Asp Asp Leu Glu Asp Lys Leu Lys Cys Thr Lys Glu Glu His Leu 
        115                 120                 125             


Cys Thr Gln Arg Met Leu Asp Gln Thr Leu Leu Asp Leu Asn Glu Met 
    130                 135                 140                 

<210>  1010
<211>  3450
<212>  DNA
<213>  Homo sapiens

<400>  1010
agggcgtagc aggcggaagt aagggtgaga ggaggctgca acgccgagcg gaggaggcag     60

gaaccggagc gcgagcagta gctgggtggg caccatggct gggatcacca ccatcgaggc    120

ggtgaagcgc aagatccagg ttctgcagca gcaggcagat gatgcagagg agcgagctga    180

gcgcctccag cgagaagttg agggagaaag gcgggcccgg gaacaggctg aggctgaggt    240

ggcctccttg aaccgtagga tccagctggt tgaagaagag ctggaccgtg ctcaggagcg    300

cctggccact gccctgcaaa agctggaaga agctgaaaaa gctgctgatg agagtgagag    360

aggtatgaag gttattgaaa accgggcctt aaaagatgaa gaaaagatgg aactccagga    420

aatccaactc aaagaagcta agcacattgc agaagaggca gataggaagt atgaagaggt    480

ggctcgtaag ttggtgatca ttgaaggaga cttggaacgc acagaggaac gagctgagct    540

ggcagagtct aagtgttctg agctggagga ggagctgaag aatgtcacca acaacctcaa    600

gtctcttgag gctcaggcgg agaagtactc tcaaaaagaa gataaatatg aggaagaaat    660

caagattctt actgataaac tcaaggaggc agagacccgt gctgagtttg ctgagagatc    720

ggtagccaag ctggaaaaga caattgatga cctggaagag cgtctctaca gccaacttga    780

gcgaaaccgc ctgctttcta atgagctgaa gctaacgctg catgatctgt gtgactgatg    840

ggcagggctc aatgatgccc attaaactga gcttactgct cacaccactg acctggaccc    900

caacaaaaag ctgattgtct ttttaaaagt tattattttg ccctgagcaa attgcatttt    960

aattggggca gttagaatgt tgatttccta acagcattgt gaagttgacc attgtgaagt   1020

ttctgtccct ttagaagaga ttatgggtga agaagggagg ggcctgagag attatagtga   1080

gaaaacttgc gagaattttg ttttccaccc ttatttgctg ctctttcact tgggcactga   1140

ctgtaggata tgttcccttg catggatgtt tttaacaata aaaggactga cttgacaagt   1200

tgttgtaact gcttcatcgg caggcccagg aatgggtcct tctgactggg tggaaaaaag   1260

ggaagtgaaa gaaaagttgt gggatatgaa tatgggtctg tgttgccatc accttctctg   1320

agttgaagat ttgagtattt tcctcacctc tttagagcag tcagagtggt ttgcttgcta   1380

gacagattag attctcctta atgttcagct gctgattttc tttctgactt ttgcgtcctt   1440

tttctggttt tatgttaatt tcaagtaact gtcacaagct agttctgttc aatagctctg   1500

cagcaatctc aaggtttgct tacaactact tgtttcagta gtattcttgg ctttgttttc   1560

tttagagatt atttgactta actgtgagcg cccttttatt tatcccatca gttattactt   1620

tggcctctac tttttcgaaa aaacatgtag tgcatgagga tcttcctgtg ctctttataa   1680

tctgagattc tgatgtttct attgtttgca atgttcaaac tccggtgagc catttcaaga   1740

gggtattgtt atgtgggcaa aacctagaaa agtggatggc tgatggttaa ggcttgctct   1800

ttcattgact gaaagctgaa agtgttggtt gggtgtggga gggagaggaa atggctgata   1860

agggccctaa ctccctcacc caggaagtgc agcaacacct acaacttcag taggcaagcc   1920

aaaggcccta caaaactggg tgatgtaata gctcacttct gtggctgaga aggcagctgc   1980

tttatcagtc tgcagcttct ctgcaacagg agcaagtctc aaagagcggg tagaccttga   2040

aatttacttc tagttcttgt aacttctctc ctttaccccc attagataaa ctgaaatgca   2100

ccaaagagga gcacctctgt acacaaagga tgctggacca gaccctgctt gacctgaatg   2160

agatgtagaa cgccccagtc ccaccctgct gctgctcctc cctctgaccc agactccgcc   2220

tgaggccagc ctgcgggaag ctgaccttta actgagggct gatctttaac tggaaggctg   2280

ctttctcctt tcaccacccc ctccttccct gtgtcttttt cgccaaactg tctctgcctc   2340

ttcccggaga atccagctgg gctagaggct gagcaccttt ggaaacaaca tttaagggaa   2400

tgtgagcaca atgcataatg tctttaaaaa gcatgttgtg atgtacacat tttgtaatta   2460

ccttttttgt tgttttgtag caaccatttg taaaacattc caaataattc cacagtcctg   2520

aagcagcaat cgaatccctt tctcactttt ggaaggtgac ttttcacctt aatgcatatt   2580

cccctctcca tagaggagag gaaaaggtgt aggcctgcct taccgagagc caaacagagc   2640

ccagggagac tccgctgtgg gaaacctcat tgttctgtac aaagtactag ctaaaccaga   2700

aaggtgattc caggaggagt tagccaaaca acaacaaaaa caaaaaatgt gctgttcaag   2760

ttttcagctt taagatatct ttggataatg ttatttctat tttttatttt tttcattaga   2820

agttaccaaa ttaagatggt aagacctctg agaccaaaat tttgtcccat ctctaccccc   2880

tcacaactgc ttacagaatg gatcatgtcc cccttatgtt gaggtgacca cttaattgct   2940

ttcctgcctc cttgaaagaa agaaagaaag aagactgtgt ttttgccact gatttagcca   3000

tgtgaaactc atctcattac ccttttctgg gtttgaagct gctgtctcta gaagtgccat   3060

ctcaattgtg ctttgtatca gtcagtgctg gagaaatctt gaatagctta tgtacaaaac   3120

tttttaaatt ttatattatt ttgaaacttt gctttgggtt tgtggcaccc tggccacccc   3180

atctggctgt gacagcctct gcagtccgtg ggctggcagt ttgttgatct tttaagtttc   3240

cttccctacc cagtccccat tttctggtaa ggtttctagg aggtctgtta ggtgtacatc   3300

ctgcagctta ttggcttaaa atgtactctc cttttatgtg gtctctttgg ggccgattgg   3360

gagaaagaga aatcaatagt gcaactgttt tgatactgaa tattgacaag tgtctttttg   3420

aaataaagaa ccagtccctc caaccctcag                                    3450


<210>  1011
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  1011


Met Ala Gly Ile Thr Thr Ile Glu Ala Val Lys Arg Lys Ile Gln Val 
1               5                   10                  15      


Leu Gln Gln Gln Ala Asp Asp Ala Glu Glu Arg Ala Glu Arg Leu Gln 
            20                  25                  30          


Arg Glu Val Glu Gly Glu Arg Arg Ala Arg Glu Gln Ala Glu Ala Glu 
        35                  40                  45              


Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu Glu Glu Leu Asp 
    50                  55                  60                  


Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys Leu Glu Glu Ala 
65                  70                  75                  80  


Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys Val Ile Glu Asn 
                85                  90                  95      


Arg Ala Leu Lys Asp Glu Glu Lys Met Glu Leu Gln Glu Ile Gln Leu 
            100                 105                 110         


Lys Glu Ala Lys His Ile Ala Glu Glu Ala Asp Arg Lys Tyr Glu Glu 
        115                 120                 125             


Val Ala Arg Lys Leu Val Ile Ile Glu Gly Asp Leu Glu Arg Thr Glu 
    130                 135                 140                 


Glu Arg Ala Glu Leu Ala Glu Ser Lys Cys Ser Glu Leu Glu Glu Glu 
145                 150                 155                 160 


Leu Lys Asn Val Thr Asn Asn Leu Lys Ser Leu Glu Ala Gln Ala Glu 
                165                 170                 175     


Lys Tyr Ser Gln Lys Glu Asp Lys Tyr Glu Glu Glu Ile Lys Ile Leu 
            180                 185                 190         


Thr Asp Lys Leu Lys Glu Ala Glu Thr Arg Ala Glu Phe Ala Glu Arg 
        195                 200                 205             


Ser Val Ala Lys Leu Glu Lys Thr Ile Asp Asp Leu Glu Glu Arg Leu 
    210                 215                 220                 


Tyr Ser Gln Leu Glu Arg Asn Arg Leu Leu Ser Asn Glu Leu Lys Leu 
225                 230                 235                 240 


Thr Leu His Asp Leu Cys Asp 
                245         

<210>  1012
<211>  1928
<212>  DNA
<213>  Homo sapiens

<400>  1012
cagggcgtag caggcggaag taagggtgag aggaggctgc aacgccgagc ggaggaggca     60

ggaaccggag cgcgagcagt agctgggtgg gcaccatggc tgggatcacc accatcgagg    120

cggtgaagcg caagatccag gttctgcagc agcaggcaga tgatgcagag gagcgagctg    180

agcgcctcca gcgagaagtt gagggaaaaa gatggaactc caggaaatcc aactcaaaga    240

agctaagcac attgcagaag aggcagatag gaagtatgaa gaggtggctc gtaagttggt    300

gatcattgaa ggagacttgg aacgcacaga ggaacgagct gagctggcag agtcccgttg    360

ccgagagatg gatgagcaga ttagactgat ggaccagaac ctgaagtgtc tgagtgctgc    420

tgaagaaaag tactctcaaa aagaagataa atatgaggaa gaaatcaaga ttcttactga    480

taaactcaag gaggcagaga cccgtgctga gtttgctgag agatcggtag ccaagctgga    540

aaagacaatt gatgacctgg aagataaact gaaatgcacc aaagaggagc acctctgtac    600

acaaaggatg ctggaccaga ccctgcttga cctgaatgag atgtagaacg ccccagtccc    660

accctgctgc tgctcctccc tctgacccag actccgcctg aggccagcct gcgggaagct    720

gacctttaac tgagggctga tctttaactg gaaggctgct ttctcctttc accaccccct    780

ccttccctgt gtctttttcg ccaaactgtc tctgcctctt cccggagaat ccagctgggc    840

tagaggctga gcacctttgg aaacaacatt taagggaatg tgagcacaat gcataatgtc    900

tttaaaaagc atgttgtgat gtacacattt tgtaattacc ttttttgttg ttttgtagca    960

accatttgta aaacattcca aataattcca cagtcctgaa gcagcaatcg aatccctttc   1020

tcacttttgg aaggtgactt ttcaccttaa tgcatattcc cctctccata gaggagagga   1080

aaaggtgtag gcctgcctta ccgagagcca aacagagccc agggagactc cgctgtggga   1140

aacctcattg ttctgtacaa agtactagct aaaccagaaa ggtgattcca ggaggagtta   1200

gccaaacaac aacaaaaaca aaaaatgtgc tgttcaagtt ttcagcttta agatatcttt   1260

ggataatgtt atttctattt tttatttttt tcattagaag ttaccaaatt aagatggtaa   1320

gacctctgag accaaaattt tgtcccatct ctaccccctc acaactgctt acagaatgga   1380

tcatgtcccc cttatgttga ggtgaccact taattgcttt cctgcctcct tgaaagaaag   1440

aaagaaagaa gactgtgttt ttgccactga tttagccatg tgaaactcat ctcattaccc   1500

ttttctgggt ttgaagctgc tgtctctaga agtgccatct caattgtgct ttgtatcagt   1560

cagtgctgga gaaatcttga atagcttatg tacaaaactt tttaaatttt atattatttt   1620

gaaactttgc tttgggtttg tggcaccctg gccaccccat ctggctgtga cagcctctgc   1680

agtccgtggg ctggcagttt gttgatcttt taagtttcct tccctaccca gtccccattt   1740

tctggtaagg tttctaggag gtctgttagg tgtacatcct gcagcttatt ggcttaaaat   1800

gtactctcct tttatgtggt ctctttgggg ccgattggga gaaagagaaa tcaatagtgc   1860

aactgttttg atactgaata ttgacaagtg tctttttgaa ataaagaacc agtccctcca   1920

accctcag                                                            1928


<210>  1013
<211>  144
<212>  PRT
<213>  Homo sapiens

<400>  1013


Met Glu Leu Gln Glu Ile Gln Leu Lys Glu Ala Lys His Ile Ala Glu 
1               5                   10                  15      


Glu Ala Asp Arg Lys Tyr Glu Glu Val Ala Arg Lys Leu Val Ile Ile 
            20                  25                  30          


Glu Gly Asp Leu Glu Arg Thr Glu Glu Arg Ala Glu Leu Ala Glu Ser 
        35                  40                  45              


Arg Cys Arg Glu Met Asp Glu Gln Ile Arg Leu Met Asp Gln Asn Leu 
    50                  55                  60                  


Lys Cys Leu Ser Ala Ala Glu Glu Lys Tyr Ser Gln Lys Glu Asp Lys 
65                  70                  75                  80  


Tyr Glu Glu Glu Ile Lys Ile Leu Thr Asp Lys Leu Lys Glu Ala Glu 
                85                  90                  95      


Thr Arg Ala Glu Phe Ala Glu Arg Ser Val Ala Lys Leu Glu Lys Thr 
            100                 105                 110         


Ile Asp Asp Leu Glu Asp Lys Leu Lys Cys Thr Lys Glu Glu His Leu 
        115                 120                 125             


Cys Thr Gln Arg Met Leu Asp Gln Thr Leu Leu Asp Leu Asn Glu Met 
    130                 135                 140                 

<210>  1014
<211>  1874
<212>  DNA
<213>  Homo sapiens

<400>  1014
tttcagggcg tagcaggcgg aagtaagggt gagaggaggc tgcaacgccg agcggaggag     60

gcaggaaccg gagcgcgagc agtagctggg tgggcaccat ggctgggatc accaccatcg    120

aggcggtgaa gcgcaagatc caggttctgc agcagcaggc agatgatgca gaggagcgag    180

ctgagcgcct ccagcgagaa gttgagggag aaaggcgggc ccgggaacag gctgaggctg    240

aggtggcctc cttgaaccgt aggatccagc tggttgaaga agagctggac cgtgctcagg    300

agcgcctggc cactgccctg caaaagctgg aagaagctga aaaagctgct gatgagagtg    360

agagaggtat gaaggttatt gaaaaccggg ccttaaaaga tgaagaaaag atggaactcc    420

aggaaatcca actcaaagaa gctaagcaca ttgcagaaga ggcagatagg aagtatgaag    480

aggtggctcg taagttggtg atcattgaag gagacttgga acgcacagag gaacgagctg    540

agctggcaga gtcccgttgc cgagagatgg atgagcagat tagactgatg gaccagaacc    600

tgaagtgtct gagtgctgct cctccctctg acccagactc cgcctgaggc cagcctgcgg    660

gaagctgacc tttaactgag ggctgatctt taactggaag gctgctttct cctttcacca    720

ccccctcctt ccctgtgtct ttttcgccaa actgtctctg cctcttcccg gagaatccag    780

ctgggctaga ggctgagcac ctttggaaac aacatttaag ggaatgtgag cacaatgcat    840

aatgtcttta aaaagcatgt tgtgatgtac acattttgta attacctttt ttgttgtttt    900

gtagcaacca tttgtaaaac attccaaata attccacagt cctgaagcag caatcgaatc    960

cctttctcac ttttggaagg tgacttttca ccttaatgca tattcccctc tccatagagg   1020

agaggaaaag gtgtaggcct gccttaccga gagccaaaca gagcccaggg agactccgct   1080

gtgggaaacc tcattgttct gtacaaagta ctagctaaac cagaaaggtg attccaggag   1140

gagttagcca aacaacaaca aaaacaaaaa atgtgctgtt caagttttca gctttaagat   1200

atctttggat aatgttattt ctatttttta tttttttcat tagaagttac caaattaaga   1260

tggtaagacc tctgagacca aaattttgtc ccatctctac cccctcacaa ctgcttacag   1320

aatggatcat gtccccctta tgttgaggtg accacttaat tgctttcctg cctccttgaa   1380

agaaagaaag aaagaagact gtgtttttgc cactgattta gccatgtgaa actcatctca   1440

ttaccctttt ctgggtttga agctgctgtc tctagaagtg ccatctcaat tgtgctttgt   1500

atcagtcagt gctggagaaa tcttgaatag cttatgtaca aaacttttta aattttatat   1560

tattttgaaa ctttgctttg ggtttgtggc accctggcca ccccatctgg ctgtgacagc   1620

ctctgcagtc cgtgggctgg cagtttgttg atcttttaag tttccttccc tacccagtcc   1680

ccattttctg gtaaggtttc taggaggtct gttaggtgta catcctgcag cttattggct   1740

taaaatgtac tctcctttta tgtggtctct ttggggccga ttgggagaaa gagaaatcaa   1800

tagtgcaact gttttgatac tgaatattga caagtgtctt tttgaaataa agaaccagtc   1860

cctccaaccc tcag                                                     1874


<210>  1015
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  1015


Met Ala Gly Ile Thr Thr Ile Glu Ala Val Lys Arg Lys Ile Gln Val 
1               5                   10                  15      


Leu Gln Gln Gln Ala Asp Asp Ala Glu Glu Arg Ala Glu Arg Leu Gln 
            20                  25                  30          


Arg Glu Val Glu Gly Glu Arg Arg Ala Arg Glu Gln Ala Glu Ala Glu 
        35                  40                  45              


Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu Glu Glu Leu Asp 
    50                  55                  60                  


Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys Leu Glu Glu Ala 
65                  70                  75                  80  


Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys Val Ile Glu Asn 
                85                  90                  95      


Arg Ala Leu Lys Asp Glu Glu Lys Met Glu Leu Gln Glu Ile Gln Leu 
            100                 105                 110         


Lys Glu Ala Lys His Ile Ala Glu Glu Ala Asp Arg Lys Tyr Glu Glu 
        115                 120                 125             


Val Ala Arg Lys Leu Val Ile Ile Glu Gly Asp Leu Glu Arg Thr Glu 
    130                 135                 140                 


Glu Arg Ala Glu Leu Ala Glu Ser Arg Cys Arg Glu Met Asp Glu Gln 
145                 150                 155                 160 


Ile Arg Leu Met Asp Gln Asn Leu Lys Cys Leu Ser Ala Ala Pro Pro 
                165                 170                 175     


Ser Asp Pro Asp Ser Ala 
            180         

<210>  1016
<211>  1873
<212>  DNA
<213>  Homo sapiens

<400>  1016
atttcagggc gtagcaggcg gaagtaaggg tgagaggagg ctgcaacgcc gagcggagga     60

ggcaggaacc ggagcgcgag cagtagctgg gtgggcacca tggctgggat caccaccatc    120

gaggcggtga agcgcaagat ccaggttctg cagcagcagg cagatgatgc agaggagcga    180

gctgagcgcc tccagcgaga agttgaggga gaaaggcggg cccgggaaca ggctgaggct    240

gaggtggcct ccttgaaccg taggatccag ctggttgaag aagagctgga ccgtgctcag    300

gagcgcctgg ccactgccct gcaaaagctg gaagaagctg aaaaagctgc tgatgagagt    360

gagagaggta tgaaggttat tgaaaaccgg gccttaaaag atgaagaaaa gatggaactc    420

caggaaatcc aactcaaaga agctaagcac attgcagaag aggcagatag gaagtatgaa    480

gaggtggctc gtaagttggt gatcattgaa ggagacttgg aacgcacaga ggaacgagct    540

gagctggcag agtcgtgaga ccagaccctg cttgacctga atgagatgta gaacgcccca    600

gtcccaccct gctgctgctc ctccctctga cccagactcc gcctgaggcc agcctgcggg    660

aagctgacct ttaactgagg gctgatcttt aactggaagg ctgctttctc ctttcaccac    720

cccctccttc cctgtgtctt tttcgccaaa ctgtctctgc ctcttcccgg agaatccagc    780

tgggctagag gctgagcacc tttggaaaca acatttaagg gaatgtgagc acaatgcata    840

atgtctttaa aaagcatgtt gtgatgtaca cattttgtaa ttaccttttt tgttgttttg    900

tagcaaccat ttgtaaaaca ttccaaataa ttccacagtc ctgaagcagc aatcgaatcc    960

ctttctcact tttggaaggt gacttttcac cttaatgcat attcccctct ccatagagga   1020

gaggaaaagg tgtaggcctg ccttaccgag agccaaacag agcccaggga gactccgctg   1080

tgggaaacct cattgttctg tacaaagtac tagctaaacc agaaaggtga ttccaggagg   1140

agttagccaa acaacaacaa aaacaaaaaa tgtgctgttc aagttttcag ctttaagata   1200

tctttggata atgttatttc tattttttat ttttttcatt agaagttacc aaattaagat   1260

ggtaagacct ctgagaccaa aattttgtcc catctctacc ccctcacaac tgcttacaga   1320

atggatcatg tcccccttat gttgaggtga ccacttaatt gctttcctgc ctccttgaaa   1380

gaaagaaaga aagaagactg tgtttttgcc actgatttag ccatgtgaaa ctcatctcat   1440

tacccttttc tgggtttgaa gctgctgtct ctagaagtgc catctcaatt gtgctttgta   1500

tcagtcagtg ctggagaaat cttgaatagc ttatgtacaa aactttttaa attttatatt   1560

attttgaaac tttgctttgg gtttgtggca ccctggccac cccatctggc tgtgacagcc   1620

tctgcagtcc gtgggctggc agtttgttga tcttttaagt ttccttccct acccagtccc   1680

cattttctgg taaggtttct aggaggtctg ttaggtgtac atcctgcagc ttattggctt   1740

aaaatgtact ctccttttat gtggtctctt tggggccgat tgggagaaag agaaatcaat   1800

agtgcaactg ttttgatact gaatattgac aagtgtcttt ttgaaataaa gaaccagtcc   1860

ctccaaccct cag                                                      1873


<210>  1017
<211>  152
<212>  PRT
<213>  Homo sapiens

<400>  1017


Met Ala Gly Ile Thr Thr Ile Glu Ala Val Lys Arg Lys Ile Gln Val 
1               5                   10                  15      


Leu Gln Gln Gln Ala Asp Asp Ala Glu Glu Arg Ala Glu Arg Leu Gln 
            20                  25                  30          


Arg Glu Val Glu Gly Glu Arg Arg Ala Arg Glu Gln Ala Glu Ala Glu 
        35                  40                  45              


Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu Glu Glu Leu Asp 
    50                  55                  60                  


Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys Leu Glu Glu Ala 
65                  70                  75                  80  


Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys Val Ile Glu Asn 
                85                  90                  95      


Arg Ala Leu Lys Asp Glu Glu Lys Met Glu Leu Gln Glu Ile Gln Leu 
            100                 105                 110         


Lys Glu Ala Lys His Ile Ala Glu Glu Ala Asp Arg Lys Tyr Glu Glu 
        115                 120                 125             


Val Ala Arg Lys Leu Val Ile Ile Glu Gly Asp Leu Glu Arg Thr Glu 
    130                 135                 140                 


Glu Arg Ala Glu Leu Ala Glu Ser 
145                 150         

<210>  1018
<211>  1150
<212>  DNA
<213>  Homo sapiens

<400>  1018
tccggtattt cagggcgtag caggcggaag taagggtgag aggaggctgc aacgccgagc     60

ggaggaggca ggaaccggag cgcgagcagt agctgggtgg gcaccatggc tgggatcacc    120

accatcgagg cggtgaagcg caagatccag gttctgcagc agcaggcaga tgatgcagag    180

gagcgagctg agcgcctcca gcgagaagtt gagggagaaa ggcgggcccg ggaacaggct    240

gaggctgagg tggcctcctt gaaccgtagg atccagctgg ttgaagaaga gctggaccgt    300

gctcaggagc gcctggccac tgccctgcaa aagctggaag aagctgaaaa agctgctgat    360

gagagtgaga gaggtatgaa ggttattgaa aaccgggcct taaaagatga agaaaagatg    420

gaactccagg aaatccaact caaagaagct aagcacattg cagaagaggc agataggaag    480

tatgaagagg tggctcgtaa gttggtgatc attgaaggag acttggaacg cacagaggaa    540

cgagctgagc tggcagagtc ccgttgccga gagatggatg agcagattag actgatggac    600

cagaacctga agtgtctgag tgctgctgaa gaaaagtact ctcaaaaaga agataaatat    660

gaggaagaaa aagactgtgt ttttgccact gatttagcca tgtgaaactc atctcattac    720

ccttttctgg gtttgaagct gctgtctcta gaagtgccat ctcaattgtg ctttgtatca    780

gtcagtgctg gagaaatctt gaatagctta tgtacaaaac tttttaaatt ttatattatt    840

ttgaaacttt gctttgggtt tgtggcaccc tggccacccc atctggctgt gacagcctct    900

gcagtccgtg ggctggcagt ttgttgatct tttaagtttc cttccctacc cagtccccat    960

tttctggtaa ggtttctagg aggtctgtta ggtgtacatc ctgcagctta ttggcttaaa   1020

atgtactctc cttttatgtg gtctctttgg ggccgattgg gagaaagaga aatcaatagt   1080

gcaactgttt tgatactgaa tattgacaag tgtctttttg aaataaagaa ccagtccctc   1140

caaccctcag                                                          1150


<210>  1019
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  1019


Met Ala Gly Ile Thr Thr Ile Glu Ala Val Lys Arg Lys Ile Gln Val 
1               5                   10                  15      


Leu Gln Gln Gln Ala Asp Asp Ala Glu Glu Arg Ala Glu Arg Leu Gln 
            20                  25                  30          


Arg Glu Val Glu Gly Glu Arg Arg Ala Arg Glu Gln Ala Glu Ala Glu 
        35                  40                  45              


Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu Glu Glu Leu Asp 
    50                  55                  60                  


Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys Leu Glu Glu Ala 
65                  70                  75                  80  


Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys Val Ile Glu Asn 
                85                  90                  95      


Arg Ala Leu Lys Asp Glu Glu Lys Met Glu Leu Gln Glu Ile Gln Leu 
            100                 105                 110         


Lys Glu Ala Lys His Ile Ala Glu Glu Ala Asp Arg Lys Tyr Glu Glu 
        115                 120                 125             


Val Ala Arg Lys Leu Val Ile Ile Glu Gly Asp Leu Glu Arg Thr Glu 
    130                 135                 140                 


Glu Arg Ala Glu Leu Ala Glu Ser Arg Cys Arg Glu Met Asp Glu Gln 
145                 150                 155                 160 


Ile Arg Leu Met Asp Gln Asn Leu Lys Cys Leu Ser Ala Ala Glu Glu 
                165                 170                 175     


Lys Tyr Ser Gln Lys Glu Asp Lys Tyr Glu Glu Glu Lys Asp Cys Val 
            180                 185                 190         


Phe Ala Thr Asp Leu Ala Met 
        195                 

<210>  1020
<211>  2071
<212>  DNA
<213>  Homo sapiens

<400>  1020
tccggtattt cagggcgtag caggcggaag taagggtgag aggaggctgc aacgccgagc     60

ggaggaggca ggaaccggag cgcgagcagt agctgggtgg gcaccatggc tgggatcacc    120

accatcgagg cggtgaagcg caagatccag gttctgcagc agcaggcaga tgatgcagag    180

gagcgagctg agcgcctcca gcgagaagtt gagggagaaa ggcgggcccg ggaacaggct    240

gaggctgagg tggcctcctt gaaccgtagg atccagctgg ttgaagaaga gctggaccgt    300

gctcaggagc gcctggccac tgccctgcaa aagctggaag aagctgaaaa agctgctgat    360

gagagtgaga gaggtatgaa ggttattgaa aaccgggcct taaaagatga agaaaagatg    420

gaactccagg aaatccaact caaagaagct aagcacattg cagaagaggc agataggaag    480

tatgaagagg tggctcgtaa gttggtgatc attgaaggag acttggaacg cacagaggaa    540

cgagctgagc tggcagagtc ccgttgccga gagatggatg agcagattag actgatggac    600

cagaacctga agtgtctgag tgctgctgaa gaaaaggcag agacccgtgc tgagtttgct    660

gagagatcgg tagccaagct ggaaaagaca attgatgacc tggaagataa actgaaatgc    720

accaaagagg agcacctctg tacacaaagg atgctggacc agaccctgct tgacctgaat    780

gagatgtaga acgccccagt cccaccctgc tgctgctcct ccctctgacc cagactccgc    840

ctgaggccag cctgcgggaa gctgaccttt aactgagggc tgatctttaa ctggaaggct    900

gctttctcct ttcaccaccc cctccttccc tgtgtctttt tcgccaaact gtctctgcct    960

cttcccggag aatccagctg ggctagaggc tgagcacctt tggaaacaac atttaaggga   1020

atgtgagcac aatgcataat gtctttaaaa agcatgttgt gatgtacaca ttttgtaatt   1080

accttttttg ttgttttgta gcaaccattt gtaaaacatt ccaaataatt ccacagtcct   1140

gaagcagcaa tcgaatccct ttctcacttt tggaaggtga cttttcacct taatgcatat   1200

tcccctctcc atagaggaga ggaaaaggtg taggcctgcc ttaccgagag ccaaacagag   1260

cccagggaga ctccgctgtg ggaaacctca ttgttctgta caaagtacta gctaaaccag   1320

aaaggtgatt ccaggaggag ttagccaaac aacaacaaaa acaaaaaatg tgctgttcaa   1380

gttttcagct ttaagatatc tttggataat gttatttcta ttttttattt ttttcattag   1440

aagttaccaa attaagatgg taagacctct gagaccaaaa ttttgtccca tctctacccc   1500

ctcacaactg cttacagaat ggatcatgtc ccccttatgt tgaggtgacc acttaattgc   1560

tttcctgcct ccttgaaaga aagaaagaaa gaagactgtg tttttgccac tgatttagcc   1620

atgtgaaact catctcatta cccttttctg ggtttgaagc tgctgtctct agaagtgcca   1680

tctcaattgt gctttgtatc agtcagtgct ggagaaatct tgaatagctt atgtacaaaa   1740

ctttttaaat tttatattat tttgaaactt tgctttgggt ttgtggcacc ctggccaccc   1800

catctggctg tgacagcctc tgcagtccgt gggctggcag tttgttgatc ttttaagttt   1860

ccttccctac ccagtcccca ttttctggta aggtttctag gaggtctgtt aggtgtacat   1920

cctgcagctt attggcttaa aatgtactct ccttttatgt ggtctctttg gggccgattg   1980

ggagaaagag aaatcaatag tgcaactgtt ttgatactga atattgacaa gtgtcttttt   2040

gaaataaaga accagtccct ccaaccctca g                                  2071


<210>  1021
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  1021


Met Ala Gly Ile Thr Thr Ile Glu Ala Val Lys Arg Lys Ile Gln Val 
1               5                   10                  15      


Leu Gln Gln Gln Ala Asp Asp Ala Glu Glu Arg Ala Glu Arg Leu Gln 
            20                  25                  30          


Arg Glu Val Glu Gly Glu Arg Arg Ala Arg Glu Gln Ala Glu Ala Glu 
        35                  40                  45              


Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu Glu Glu Leu Asp 
    50                  55                  60                  


Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys Leu Glu Glu Ala 
65                  70                  75                  80  


Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys Val Ile Glu Asn 
                85                  90                  95      


Arg Ala Leu Lys Asp Glu Glu Lys Met Glu Leu Gln Glu Ile Gln Leu 
            100                 105                 110         


Lys Glu Ala Lys His Ile Ala Glu Glu Ala Asp Arg Lys Tyr Glu Glu 
        115                 120                 125             


Val Ala Arg Lys Leu Val Ile Ile Glu Gly Asp Leu Glu Arg Thr Glu 
    130                 135                 140                 


Glu Arg Ala Glu Leu Ala Glu Ser Arg Cys Arg Glu Met Asp Glu Gln 
145                 150                 155                 160 


Ile Arg Leu Met Asp Gln Asn Leu Lys Cys Leu Ser Ala Ala Glu Glu 
                165                 170                 175     


Lys Ala Glu Thr Arg Ala Glu Phe Ala Glu Arg Ser Val Ala Lys Leu 
            180                 185                 190         


Glu Lys Thr Ile Asp Asp Leu Glu Asp Lys Leu Lys Cys Thr Lys Glu 
        195                 200                 205             


Glu His Leu Cys Thr Gln Arg Met Leu Asp Gln Thr Leu Leu Asp Leu 
    210                 215                 220                 


Asn Glu Met 
225         

<210>  1022
<211>  2238
<212>  DNA
<213>  Homo sapiens

<400>  1022
gtcacatccg ggcgggttgg tgagttccgg tatttcaggg cgtagcaggc ggaagtaagg     60

gtgagaggag gctgcaacgc cgagcggagg aggcaggaac cggagcgcga gcagtagctg    120

ggtgggcacc atggctggga tcaccaccat cgaggcggtg aagcgcaaga tccaggttct    180

gcagcagcag gcagatgatg cagaggagcg agctgagcgc ctccagcgag aagttgaggg    240

agaaaggcgg gcccgggaac aggctgaggc tgaggtggcc tccttgaacc gtaggatcca    300

gctggttgaa gaagagctgg accgtgctca ggagcgcctg gccactgccc tgcaaaagct    360

ggaagaagct gaaaaagctg ctgatgagag tgagagaggt atgaaggtta ttgaaaaccg    420

ggccttaaaa gatgaagaaa agatggaact ccaggaaatc caactcaaag aagctaagca    480

cattgcagaa gaggcagata ggaagtatga agaggtggct cgtaagttgg tgatcattga    540

aggagacttg gaacgcacag aggaacgagc tgagctggca gagtcccgtt gccgagagat    600

ggatgagcag attagactga tggaccagaa cctgaagtgt ctgagtgctg ctgaagaaaa    660

gtactctcaa aaagaagata aatatgagga agaaatcaag attcttactg ataaactcaa    720

ggaggcagag acccgtgctg agtttgctga gagatcggta gccaagctgg aaaagacaat    780

tgatgacctg gaagatgagc tctatgccca gaaactgaag tacaaggcca ttagcgagga    840

gctggaccac gccctcaatg acatgacctc tatataaact gaaatgcacc aaagaggagc    900

acctctgtac acaaaggatg ctggaccaga ccctgcttga cctgaatgag atgtagaacg    960

ccccagtccc accctgctgc tgctcctccc tctgacccag actccgcctg aggccagcct   1020

gcgggaagct gacctttaac tgagggctga tctttaactg gaaggctgct ttctcctttc   1080

accaccccct ccttccctgt gtctttttcg ccaaactgtc tctgcctctt cccggagaat   1140

ccagctgggc tagaggctga gcacctttgg aaacaacatt taagggaatg tgagcacaat   1200

gcataatgtc tttaaaaagc atgttgtgat gtacacattt tgtaattacc ttttttgttg   1260

ttttgtagca accatttgta aaacattcca aataattcca cagtcctgaa gcagcaatcg   1320

aatccctttc tcacttttgg aaggtgactt ttcaccttaa tgcatattcc cctctccata   1380

gaggagagga aaaggtgtag gcctgcctta ccgagagcca aacagagccc agggagactc   1440

cgctgtggga aacctcattg ttctgtacaa agtactagct aaaccagaaa ggtgattcca   1500

ggaggagtta gccaaacaac aacaaaaaca aaaaatgtgc tgttcaagtt ttcagcttta   1560

agatatcttt ggataatgtt atttctattt tttatttttt tcattagaag ttaccaaatt   1620

aagatggtaa gacctctgag accaaaattt tgtcccatct ctaccccctc acaactgctt   1680

acagaatgga tcatgtcccc cttatgttga ggtgaccact taattgcttt cctgcctcct   1740

tgaaagaaag aaagaaagaa gactgtgttt ttgccactga tttagccatg tgaaactcat   1800

ctcattaccc ttttctgggt ttgaagctgc tgtctctaga agtgccatct caattgtgct   1860

ttgtatcagt cagtgctgga gaaatcttga atagcttatg tacaaaactt tttaaatttt   1920

atattatttt gaaactttgc tttgggtttg tggcaccctg gccaccccat ctggctgtga   1980

cagcctctgc agtccgtggg ctggcagttt gttgatcttt taagtttcct tccctaccca   2040

gtccccattt tctggtaagg tttctaggag gtctgttagg tgtacatcct gcagcttatt   2100

ggcttaaaat gtactctcct tttatgtggt ctctttgggg ccgattggga gaaagagaaa   2160

tcaatagtgc aactgttttg atactgaata ttgacaagtg tctttttgaa ataaagaacc   2220

agtccctcca accctcag                                                 2238


<210>  1023
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  1023


Met Ala Gly Ile Thr Thr Ile Glu Ala Val Lys Arg Lys Ile Gln Val 
1               5                   10                  15      


Leu Gln Gln Gln Ala Asp Asp Ala Glu Glu Arg Ala Glu Arg Leu Gln 
            20                  25                  30          


Arg Glu Val Glu Gly Glu Arg Arg Ala Arg Glu Gln Ala Glu Ala Glu 
        35                  40                  45              


Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu Glu Glu Leu Asp 
    50                  55                  60                  


Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys Leu Glu Glu Ala 
65                  70                  75                  80  


Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys Val Ile Glu Asn 
                85                  90                  95      


Arg Ala Leu Lys Asp Glu Glu Lys Met Glu Leu Gln Glu Ile Gln Leu 
            100                 105                 110         


Lys Glu Ala Lys His Ile Ala Glu Glu Ala Asp Arg Lys Tyr Glu Glu 
        115                 120                 125             


Val Ala Arg Lys Leu Val Ile Ile Glu Gly Asp Leu Glu Arg Thr Glu 
    130                 135                 140                 


Glu Arg Ala Glu Leu Ala Glu Ser Arg Cys Arg Glu Met Asp Glu Gln 
145                 150                 155                 160 


Ile Arg Leu Met Asp Gln Asn Leu Lys Cys Leu Ser Ala Ala Glu Glu 
                165                 170                 175     


Lys Tyr Ser Gln Lys Glu Asp Lys Tyr Glu Glu Glu Ile Lys Ile Leu 
            180                 185                 190         


Thr Asp Lys Leu Lys Glu Ala Glu Thr Arg Ala Glu Phe Ala Glu Arg 
        195                 200                 205             


Ser Val Ala Lys Leu Glu Lys Thr Ile Asp Asp Leu Glu Asp Glu Leu 
    210                 215                 220                 


Tyr Ala Gln Lys Leu Lys Tyr Lys Ala Ile Ser Glu Glu Leu Asp His 
225                 230                 235                 240 


Ala Leu Asn Asp Met Thr Ser Ile 
                245             

<210>  1024
<211>  2159
<212>  DNA
<213>  Homo sapiens

<400>  1024
gtcacatccg ggcgggttgg tgagttccgg tatttcaggg cgtagcaggc ggaagtaagg     60

gtgagaggag gctgcaacgc cgagcggagg aggcaggaac cggagcgcga gcagtagctg    120

ggtgggcacc atggctggga tcaccaccat cgaggcggtg aagcgcaaga tccaggttct    180

gcagcagcag gcagatgatg cagaggagcg agctgagcgc ctccagcgag aagttgaggg    240

agaaaggcgg gcccgggaac aggctgaggc tgaggtggcc tccttgaacc gtaggatcca    300

gctggttgaa gaagagctgg accgtgctca ggagcgcctg gccactgccc tgcaaaagct    360

ggaagaagct gaaaaagctg ctgatgagag tgagagaggt atgaaggtta ttgaaaaccg    420

ggccttaaaa gatgaagaaa agatggaact ccaggaaatc caactcaaag aagctaagca    480

cattgcagaa gaggcagata ggaagtatga agaggtggct cgtaagttgg tgatcattga    540

aggagacttg gaacgcacag aggaacgagc tgagctggca gagtcccgtt gccgagagat    600

ggatgagcag attagactga tggaccagaa cctgaagtgt ctgagtgctg ctgaagaaaa    660

gtactctcaa aaagaagata aatatgagga agaaatcaag attcttactg ataaactcaa    720

ggaggcagag acccgtgctg agtttgctga gagatcggta gccaagctgg aaaagacaat    780

tgatgacctg gaagataaac tgaaatgcac caaagaggag cacctctgta cacaaaggat    840

gctggaccag accctgcttg acctgaatga gatgtagaac gccccagtcc caccctgctg    900

ctgctcctcc ctctgaccca gactccgcct gaggccagcc tgcgggaagc tgacctttaa    960

ctgagggctg atctttaact ggaaggctgc tttctccttt caccaccccc tccttccctg   1020

tgtctttttc gccaaactgt ctctgcctct tcccggagaa tccagctggg ctagaggctg   1080

agcacctttg gaaacaacat ttaagggaat gtgagcacaa tgcataatgt ctttaaaaag   1140

catgttgtga tgtacacatt ttgtaattac cttttttgtt gttttgtagc aaccatttgt   1200

aaaacattcc aaataattcc acagtcctga agcagcaatc gaatcccttt ctcacttttg   1260

gaaggtgact tttcacctta atgcatattc ccctctccat agaggagagg aaaaggtgta   1320

ggcctgcctt accgagagcc aaacagagcc cagggagact ccgctgtggg aaacctcatt   1380

gttctgtaca aagtactagc taaaccagaa aggtgattcc aggaggagtt agccaaacaa   1440

caacaaaaac aaaaaatgtg ctgttcaagt tttcagcttt aagatatctt tggataatgt   1500

tatttctatt ttttattttt ttcattagaa gttaccaaat taagatggta agacctctga   1560

gaccaaaatt ttgtcccatc tctaccccct cacaactgct tacagaatgg atcatgtccc   1620

ccttatgttg aggtgaccac ttaattgctt tcctgcctcc ttgaaagaaa gaaagaaaga   1680

agactgtgtt tttgccactg atttagccat gtgaaactca tctcattacc cttttctggg   1740

tttgaagctg ctgtctctag aagtgccatc tcaattgtgc tttgtatcag tcagtgctgg   1800

agaaatcttg aatagcttat gtacaaaact ttttaaattt tatattattt tgaaactttg   1860

ctttgggttt gtggcaccct ggccacccca tctggctgtg acagcctctg cagtccgtgg   1920

gctggcagtt tgttgatctt ttaagtttcc ttccctaccc agtccccatt ttctggtaag   1980

gtttctagga ggtctgttag gtgtacatcc tgcagcttat tggcttaaaa tgtactctcc   2040

ttttatgtgg tctctttggg gccgattggg agaaagagaa atcaatagtg caactgtttt   2100

gatactgaat attgacaagt gtctttttga aataaagaac cagtccctcc aaccctcag    2159


<210>  1025
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  1025


Met Ala Gly Ile Thr Thr Ile Glu Ala Val Lys Arg Lys Ile Gln Val 
1               5                   10                  15      


Leu Gln Gln Gln Ala Asp Asp Ala Glu Glu Arg Ala Glu Arg Leu Gln 
            20                  25                  30          


Arg Glu Val Glu Gly Glu Arg Arg Ala Arg Glu Gln Ala Glu Ala Glu 
        35                  40                  45              


Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu Glu Glu Leu Asp 
    50                  55                  60                  


Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys Leu Glu Glu Ala 
65                  70                  75                  80  


Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys Val Ile Glu Asn 
                85                  90                  95      


Arg Ala Leu Lys Asp Glu Glu Lys Met Glu Leu Gln Glu Ile Gln Leu 
            100                 105                 110         


Lys Glu Ala Lys His Ile Ala Glu Glu Ala Asp Arg Lys Tyr Glu Glu 
        115                 120                 125             


Val Ala Arg Lys Leu Val Ile Ile Glu Gly Asp Leu Glu Arg Thr Glu 
    130                 135                 140                 


Glu Arg Ala Glu Leu Ala Glu Ser Arg Cys Arg Glu Met Asp Glu Gln 
145                 150                 155                 160 


Ile Arg Leu Met Asp Gln Asn Leu Lys Cys Leu Ser Ala Ala Glu Glu 
                165                 170                 175     


Lys Tyr Ser Gln Lys Glu Asp Lys Tyr Glu Glu Glu Ile Lys Ile Leu 
            180                 185                 190         


Thr Asp Lys Leu Lys Glu Ala Glu Thr Arg Ala Glu Phe Ala Glu Arg 
        195                 200                 205             


Ser Val Ala Lys Leu Glu Lys Thr Ile Asp Asp Leu Glu Asp Lys Leu 
    210                 215                 220                 


Lys Cys Thr Lys Glu Glu His Leu Cys Thr Gln Arg Met Leu Asp Gln 
225                 230                 235                 240 


Thr Leu Leu Asp Leu Asn Glu Met 
                245             

<210>  1026
<211>  1444
<212>  DNA
<213>  Homo sapiens

<400>  1026
gtcacatccg ggcgggttgg tgagttccgg tatttcaggg cgtagcaggc ggaagtaagg     60

gtgagaggag gctgcaacgc cgagcggagg aggcaggaac cggagcgcga gcagtagctg    120

ggtgggcacc atggctggga tcaccaccat cgaggcggtg aagcgcaaga tccaggttct    180

gcagcagcag gcagatgatg cagaggagcg agctgagcgc ctccagcgag aagttgaggg    240

agaaaggcgg gcccgggaac aggctgaggc tgaggtggcc tccttgaacc gtaggatcca    300

gctggttgaa gaagagctgg accgtgctca ggagcgcctg gccactgccc tgcaaaagct    360

ggaagaagct gaaaaagctg ctgatgagag tgagagaggt atgaaggtta ttgaaaaccg    420

ggccttaaaa gatgaagaaa agatggaact ccaggaaatc caactcaaag aagctaagca    480

cattgcagaa gaggcagata ggaagtatga agaggtggct cgtaagttgg tgatcattga    540

aggagacttg gaacgcacag aggaacgagc tgagctggca gagtcccgtt gccgagagat    600

ggatgagcag attagactga tggaccagaa cctgaagtgt ctgagtgctg ctgaagaaaa    660

gtactctcaa aaagaagata aatatgagga agaaatcaag attcttactg ataaactcaa    720

ggaggcagag acccgtgctg agtttgctga gagatcggta gccaagctgg aaaagacaat    780

tgatgacctg gaagataaac tgaaatgcac caaagaggag cacctctgta cacaaaggat    840

gctggaccag accctgcttg acctgaatga gatgtagaac gccccagtcc caccctgctg    900

ctgctcctcc ctctgaccca gactccgcct gaggccagcc tgcgggaagc tgacctttaa    960

ctgagggctg atctttaact ggaaggctgc tttctccttt caccaccccc tccttccctg   1020

tgtctttttc gccaaactgt ctctgcctct tcccggagaa tccagctggg ctagaggctg   1080

agcacctttg gaaacaacat ttaagggaat gtgagcacaa tgcataatgt ctttaaaaag   1140

catgttgtga tgtacacatt ttgtaattac cttttttgtt gttttgtagc aaccatttgt   1200

aaaacattcc aaataattcc acagtcctga agcagcaatc gaatcccttt ctcacttttg   1260

gaaggtgact tttcacctta atgcatattc ccctctccat agaggagagg aaaaggtgta   1320

ggcctgcctt accgagagcc aaacagagcc cagggagact ccgctgtggg aaacctcatt   1380

gttctgtaca aagtactagc taaaccagaa aggtgattcc aggaggagtt agccaaacaa   1440

caac                                                                1444


<210>  1027
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  1027


Met Ala Gly Ile Thr Thr Ile Glu Ala Val Lys Arg Lys Ile Gln Val 
1               5                   10                  15      


Leu Gln Gln Gln Ala Asp Asp Ala Glu Glu Arg Ala Glu Arg Leu Gln 
            20                  25                  30          


Arg Glu Val Glu Gly Glu Arg Arg Ala Arg Glu Gln Ala Glu Ala Glu 
        35                  40                  45              


Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu Glu Glu Leu Asp 
    50                  55                  60                  


Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys Leu Glu Glu Ala 
65                  70                  75                  80  


Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys Val Ile Glu Asn 
                85                  90                  95      


Arg Ala Leu Lys Asp Glu Glu Lys Met Glu Leu Gln Glu Ile Gln Leu 
            100                 105                 110         


Lys Glu Ala Lys His Ile Ala Glu Glu Ala Asp Arg Lys Tyr Glu Glu 
        115                 120                 125             


Val Ala Arg Lys Leu Val Ile Ile Glu Gly Asp Leu Glu Arg Thr Glu 
    130                 135                 140                 


Glu Arg Ala Glu Leu Ala Glu Ser Arg Cys Arg Glu Met Asp Glu Gln 
145                 150                 155                 160 


Ile Arg Leu Met Asp Gln Asn Leu Lys Cys Leu Ser Ala Ala Glu Glu 
                165                 170                 175     


Lys Tyr Ser Gln Lys Glu Asp Lys Tyr Glu Glu Glu Ile Lys Ile Leu 
            180                 185                 190         


Thr Asp Lys Leu Lys Glu Ala Glu Thr Arg Ala Glu Phe Ala Glu Arg 
        195                 200                 205             


Ser Val Ala Lys Leu Glu Lys Thr Ile Asp Asp Leu Glu Asp Lys Leu 
    210                 215                 220                 


Lys Cys Thr Lys Glu Glu His Leu Cys Thr Gln Arg Met Leu Asp Gln 
225                 230                 235                 240 


Thr Leu Leu Asp Leu Asn Glu Met 
                245             

<210>  1028
<211>  894
<212>  DNA
<213>  Homo sapiens

<400>  1028
caggctgagg ctgaggtggc ctccttgaac cgtaggatcc agctggttga agaagagctg     60

gaccgtgctc aggagcgcct ggccactgcc ctgcaaaagc tggaagaagc tgaaaaagct    120

gctgatgaga gtgagagagg tatgaaggtt attgaaaacc gggccttaaa agatgaagaa    180

aagatggaac tccaggaaat ccaactcaaa gaagctaagc acattgcaga agaggcagat    240

aggaagtatg aagaggtggc tcgtaagttg gtgatcattg aaggagactt ggaacgcaca    300

gaggaacgag ctgagctggc agagtcccgt tgccgagaga tggatgagca gattagactg    360

atggaccaga acctgaagtg tctgagtgct gctgaagaaa agtactctca aaaagaagat    420

aaatatgagg aagaaatcaa gattcttact gataaactca aggaggcaga gacccgtgct    480

gagtttgctg agagatcggt agccaagctg gaaaagacaa ttgatgacct ggaagataaa    540

ctgaaatgca ccaaagagga gcacctctgt acacaaagga tgctggacca gaccctgctt    600

gacctgaatg agatgtagaa cgccccagtc ccaccctgct gctgctcctc cctctgaccc    660

agactccgcc tgaggccagc ctgcgggaag ctgaccttta actgagggct gatctttaac    720

tggaaggctg ctttctcctt tcaccacccc ctccttccct gtgtcttttt cgccaaactg    780

tctctgcctc ttcccggaga atccagctgg gctagaggct gagcaccttt ggaaacaaca    840

tttaagggaa tgtgagcaca atgcataatg tctttaaaaa gcatgttgtg atgt          894


<210>  1029
<211>  158
<212>  PRT
<213>  Homo sapiens

<400>  1029


Met Lys Val Ile Glu Asn Arg Ala Leu Lys Asp Glu Glu Lys Met Glu 
1               5                   10                  15      


Leu Gln Glu Ile Gln Leu Lys Glu Ala Lys His Ile Ala Glu Glu Ala 
            20                  25                  30          


Asp Arg Lys Tyr Glu Glu Val Ala Arg Lys Leu Val Ile Ile Glu Gly 
        35                  40                  45              


Asp Leu Glu Arg Thr Glu Glu Arg Ala Glu Leu Ala Glu Ser Arg Cys 
    50                  55                  60                  


Arg Glu Met Asp Glu Gln Ile Arg Leu Met Asp Gln Asn Leu Lys Cys 
65                  70                  75                  80  


Leu Ser Ala Ala Glu Glu Lys Tyr Ser Gln Lys Glu Asp Lys Tyr Glu 
                85                  90                  95      


Glu Glu Ile Lys Ile Leu Thr Asp Lys Leu Lys Glu Ala Glu Thr Arg 
            100                 105                 110         


Ala Glu Phe Ala Glu Arg Ser Val Ala Lys Leu Glu Lys Thr Ile Asp 
        115                 120                 125             


Asp Leu Glu Asp Lys Leu Lys Cys Thr Lys Glu Glu His Leu Cys Thr 
    130                 135                 140                 


Gln Arg Met Leu Asp Gln Thr Leu Leu Asp Leu Asn Glu Met 
145                 150                 155             

<210>  1030
<211>  948
<212>  DNA
<213>  Homo sapiens

<400>  1030
gcacggtcct ctgaaggccg gcgggctcgg agatgaagtt gggatctcgg aggatgggct     60

gaggctgagg tggcctcctt gaaccgtagg atccagctgg ttgaagaaga gctggaccgt    120

gctcaggagc gcctggccac tgccctgcaa aagctggaag aagctgaaaa agctgctgat    180

gagagtgaga gaggtatgaa ggttattgaa aaccgggcct taaaagatga agaaaagatg    240

gaactccagg aaatccaact caaagaagct aagcacattg cagaagaggc agataggaag    300

tatgaagagg tggctcgtaa gttggtgatc attgaaggag acttggaacg cacagaggaa    360

cgagctgagc tggcagagtc ccgttgccga gagatggatg agcagattag actgatggac    420

cagaacctga agtgtctgag tgctgctgaa gaaaagtact ctcaaaaaga agataaatat    480

gaggaagaaa tcaagattct tactgataaa ctcaaggagg cagagacccg tgctgagttt    540

gctgagagat cggtagccaa gctggaaaag acaattgatg acctggaaga taaactgaaa    600

tgcaccaaag aggagcacct ctgtacacaa aggatgctgg accagaccct gcttgacctg    660

aatgagatgt agaacgcccc agtcccaccc tgctgctgct cctccctctg acccagactc    720

cgcctgaggc cagcctgcgg gaagctgacc tttaactgag ggctgatctt taactggaag    780

gctgctttct cctttcacca ccccctcctt ccctgtgtct ttttcgccaa actgtctctg    840

cctcttcccg gagaatccag ctgggctaga ggctgagcac ctttggaaac aacatttaag    900

ggaatgtgag cacaatgcat aatgtcttta aaaagcatgt tgtgatgt                 948


<210>  1031
<211>  158
<212>  PRT
<213>  Homo sapiens

<400>  1031


Met Lys Val Ile Glu Asn Arg Ala Leu Lys Asp Glu Glu Lys Met Glu 
1               5                   10                  15      


Leu Gln Glu Ile Gln Leu Lys Glu Ala Lys His Ile Ala Glu Glu Ala 
            20                  25                  30          


Asp Arg Lys Tyr Glu Glu Val Ala Arg Lys Leu Val Ile Ile Glu Gly 
        35                  40                  45              


Asp Leu Glu Arg Thr Glu Glu Arg Ala Glu Leu Ala Glu Ser Arg Cys 
    50                  55                  60                  


Arg Glu Met Asp Glu Gln Ile Arg Leu Met Asp Gln Asn Leu Lys Cys 
65                  70                  75                  80  


Leu Ser Ala Ala Glu Glu Lys Tyr Ser Gln Lys Glu Asp Lys Tyr Glu 
                85                  90                  95      


Glu Glu Ile Lys Ile Leu Thr Asp Lys Leu Lys Glu Ala Glu Thr Arg 
            100                 105                 110         


Ala Glu Phe Ala Glu Arg Ser Val Ala Lys Leu Glu Lys Thr Ile Asp 
        115                 120                 125             


Asp Leu Glu Asp Lys Leu Lys Cys Thr Lys Glu Glu His Leu Cys Thr 
    130                 135                 140                 


Gln Arg Met Leu Asp Gln Thr Leu Leu Asp Leu Asn Glu Met 
145                 150                 155             

<210>  1032
<211>  1014
<212>  DNA
<213>  Homo sapiens

<400>  1032
agggcgtagc aggcggaagt aagggtgaga ggaggctgca acgccgagcg gaggaggcag     60

gaaccggagc gcgagcagta gctgggtggg caccatggct gggatcacca ccatcgaggc    120

ggtgaagcgc aagatccagg ttctgcagca gcaggcagat gatgcagagg agcgagctga    180

gcgcctccag cgagaagttg agggagaaag gcgggcccgg gaacaggctg aggctgaggt    240

ggcctccttg aaccgtagga tccagctggt tgaagaagag ctggaccgtg ctcaggagcg    300

cctggccact gccctgcaaa agctggaaga aaagctaagc acattgcaga agaggcagat    360

aggaagtatg aagaggtggc tcgtaagttg gtgatcattg aaggagactt ggaacgcaca    420

gaggaacgag ctgagctggc agagtcccgt tgccgagaga tggatgagca gattagactg    480

atggaccaga acctgaagtg tctgagtgct gctgaagaaa agtactctca aaaagaagat    540

aaatatgagg aagaaatcaa gattcttact gataaactca aggaggcaga gacccgtgct    600

gagtttgctg agagatcggt agccaagctg gaaaagacaa ttgatgacct ggaagataaa    660

ctgaaatgca ccaaagagga gcacctctgt acacaaagga tgctggacca gaccctgctt    720

gacctgaatg agatgtagaa cgccccagtc ccaccctgct gctgctcctc cctctgaccc    780

agactccgcc tgaggccagc ctgcgggaag ctgaccttta actgagggct gatctttaac    840

tggaaggctg ctttctcctt tcaccacccc ctccttccct gtgtcttttt cgccaaactg    900

tctctgcctc ttcccggaga atccagctgg gctagaggct gagcaccttt ggaaacaaca    960

tttaagggaa tgtgagcaca atgcataatg tctttaaaaa gcatgttgtg atgt         1014


<210>  1033
<211>  99
<212>  PRT
<213>  Homo sapiens

<400>  1033


Met Ala Gly Ile Thr Thr Ile Glu Ala Val Lys Arg Lys Ile Gln Val 
1               5                   10                  15      


Leu Gln Gln Gln Ala Asp Asp Ala Glu Glu Arg Ala Glu Arg Leu Gln 
            20                  25                  30          


Arg Glu Val Glu Gly Glu Arg Arg Ala Arg Glu Gln Ala Glu Ala Glu 
        35                  40                  45              


Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu Glu Glu Leu Asp 
    50                  55                  60                  


Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys Leu Glu Glu Lys 
65                  70                  75                  80  


Leu Ser Thr Leu Gln Lys Arg Gln Ile Gly Ser Met Lys Arg Trp Leu 
                85                  90                  95      


Val Ser Trp 
            

<210>  1034
<211>  922
<212>  DNA
<213>  Homo sapiens

<400>  1034
cagggcgtag caggcggaag taagggtgag aggaggctgc aacgccgagc ggaggaggca     60

ggaaccggag cgcgagcagt agctgggtgg gcaccatggc tgggatcacc accatcgagg    120

cggtgaagcg caagatccag gttctgcagc agcaggcaga tgatgcagag gagcgagctg    180

agcgcctcca gcgagaagtt gagggaaaaa gatggaactc caggaaatcc aactcaaaga    240

agctaagcac attgcagaag aggcagatag gaagtatgaa gaggtggctc gtaagttggt    300

gatcattgaa ggagacttgg aacgcacaga ggaacgagct gagctggcag agtcccgttg    360

ccgagagatg gatgagcaga ttagactgat ggaccagaac ctgaagtgtc tgagtgctgc    420

tgaagaaaag tactctcaaa aagaagataa atatgaggaa gaaatcaaga ttcttactga    480

taaactcaag gaggcagaga cccgtgctga gtttgctgag agatcggtag ccaagctgga    540

aaagacaatt gatgacctgg aagataaact gaaatgcacc aaagaggagc acctctgtac    600

acaaaggatg ctggaccaga ccctgcttga cctgaatgag atgtagaacg ccccagtccc    660

accctgctgc tgctcctccc tctgacccag actccgcctg aggccagcct gcgggaagct    720

gacctttaac tgagggctga tctttaactg gaaggctgct ttctcctttc accaccccct    780

ccttccctgt gtctttttcg ccaaactgtc tctgcctctt cccggagaat ccagctgggc    840

tagaggctga gcacctttgg aaacaacatt taagggaatg tgagcacaat gcataatgtc    900

tttaaaaagc atgttgtgat gt                                             922


<210>  1035
<211>  144
<212>  PRT
<213>  Homo sapiens

<400>  1035


Met Glu Leu Gln Glu Ile Gln Leu Lys Glu Ala Lys His Ile Ala Glu 
1               5                   10                  15      


Glu Ala Asp Arg Lys Tyr Glu Glu Val Ala Arg Lys Leu Val Ile Ile 
            20                  25                  30          


Glu Gly Asp Leu Glu Arg Thr Glu Glu Arg Ala Glu Leu Ala Glu Ser 
        35                  40                  45              


Arg Cys Arg Glu Met Asp Glu Gln Ile Arg Leu Met Asp Gln Asn Leu 
    50                  55                  60                  


Lys Cys Leu Ser Ala Ala Glu Glu Lys Tyr Ser Gln Lys Glu Asp Lys 
65                  70                  75                  80  


Tyr Glu Glu Glu Ile Lys Ile Leu Thr Asp Lys Leu Lys Glu Ala Glu 
                85                  90                  95      


Thr Arg Ala Glu Phe Ala Glu Arg Ser Val Ala Lys Leu Glu Lys Thr 
            100                 105                 110         


Ile Asp Asp Leu Glu Asp Lys Leu Lys Cys Thr Lys Glu Glu His Leu 
        115                 120                 125             


Cys Thr Gln Arg Met Leu Asp Gln Thr Leu Leu Asp Leu Asn Glu Met 
    130                 135                 140                 

<210>  1036
<211>  1153
<212>  DNA
<213>  Homo sapiens

<400>  1036
gtcacatccg ggcgggttgg tgagttccgg tatttcaggg cgtagcaggc ggaagtaagg     60

gtgagaggag gctgcaacgc cgagcggagg aggcaggaac cggagcgcga gcagtagctg    120

ggtgggcacc atggctggga tcaccaccat cgaggcggtg aagcgcaaga tccaggttct    180

gcagcagcag gcagatgatg cagaggagcg agctgagcgc ctccagcgag aagttgaggg    240

agaaaggcgg gcccgggaac aggctgaggc tgaggtggcc tccttgaacc gtaggatcca    300

gctggttgaa gaagagctgg accgtgctca ggagcgcctg gccactgccc tgcaaaagct    360

ggaagaagct gaaaaagctg ctgatgagag tgagagaggt atgaaggtta ttgaaaaccg    420

ggccttaaaa gatgaagaaa agatggaact ccaggaaatc caactcaaag aagctaagca    480

cattgcagaa gaggcagata ggaagtatga agaggtggct cgtaagttgg tgatcattga    540

aggagacttg gaacgcacag aggaacgagc tgagctggca gagtcccgtt gccgagagat    600

ggatgagcag attagactga tggaccagaa cctgaagtgt ctgagtgctg ctgaagaaaa    660

gtactctcaa aaagaagata aatatgagga agaaatcaag attcttactg ataaactcaa    720

ggaggcagag acccgtgctg agtttgctga gagatcggta gccaagctgg aaaagacaat    780

tgatgacctg gaagataaac tgaaatgcac caaagaggag cacctctgta cacaaaggat    840

gctggaccag accctgcttg acctgaatga gatgtagaac gccccagtcc caccctgctg    900

ctgctcctcc ctctgaccca gactccgcct gaggccagcc tgcgggaagc tgacctttaa    960

ctgagggctg atctttaact ggaaggctgc tttctccttt caccaccccc tccttccctg   1020

tgtctttttc gccaaactgt ctctgcctct tcccggagaa tccagctggg ctagaggctg   1080

agcacctttg gaaacaacat ttaagggaat gtgagcacaa tgcataatgt ctttaaaaag   1140

catgttgtga tgt                                                      1153


<210>  1037
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  1037


Met Ala Gly Ile Thr Thr Ile Glu Ala Val Lys Arg Lys Ile Gln Val 
1               5                   10                  15      


Leu Gln Gln Gln Ala Asp Asp Ala Glu Glu Arg Ala Glu Arg Leu Gln 
            20                  25                  30          


Arg Glu Val Glu Gly Glu Arg Arg Ala Arg Glu Gln Ala Glu Ala Glu 
        35                  40                  45              


Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu Glu Glu Leu Asp 
    50                  55                  60                  


Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys Leu Glu Glu Ala 
65                  70                  75                  80  


Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys Val Ile Glu Asn 
                85                  90                  95      


Arg Ala Leu Lys Asp Glu Glu Lys Met Glu Leu Gln Glu Ile Gln Leu 
            100                 105                 110         


Lys Glu Ala Lys His Ile Ala Glu Glu Ala Asp Arg Lys Tyr Glu Glu 
        115                 120                 125             


Val Ala Arg Lys Leu Val Ile Ile Glu Gly Asp Leu Glu Arg Thr Glu 
    130                 135                 140                 


Glu Arg Ala Glu Leu Ala Glu Ser Arg Cys Arg Glu Met Asp Glu Gln 
145                 150                 155                 160 


Ile Arg Leu Met Asp Gln Asn Leu Lys Cys Leu Ser Ala Ala Glu Glu 
                165                 170                 175     


Lys Tyr Ser Gln Lys Glu Asp Lys Tyr Glu Glu Glu Ile Lys Ile Leu 
            180                 185                 190         


Thr Asp Lys Leu Lys Glu Ala Glu Thr Arg Ala Glu Phe Ala Glu Arg 
        195                 200                 205             


Ser Val Ala Lys Leu Glu Lys Thr Ile Asp Asp Leu Glu Asp Lys Leu 
    210                 215                 220                 


Lys Cys Thr Lys Glu Glu His Leu Cys Thr Gln Arg Met Leu Asp Gln 
225                 230                 235                 240 


Thr Leu Leu Asp Leu Asn Glu Met 
                245             

<210>  1038
<211>  1195
<212>  DNA
<213>  Homo sapiens

<400>  1038
agggcgtagc aggcggaagt aagggtgaga ggaggctgca acgccgagcg gaggaggcag     60

gaaccggagc gcgagcagta gctgggtggg caccatggct gggatcacca ccatcgaggc    120

ggtgaagcgc aagatccagg ttctgcagca gcaggcagat gatgcagagg agcgagctga    180

gcgcctccag cgagaagttg agggagaaag gcgggcccgg gaacaggctg aggctgaggt    240

ggcctccttg aaccgtagga tccagctggt tgaagaagag ctggaccgtg ctcaggagcg    300

cctggccact gccctgcaaa agctggaaga agctgaaaaa gctgctgatg agagtgagag    360

aggtatgaag gttattgaaa accgggcctt aaaagatgaa gaaaagatgg aactccagga    420

aatccaactc aaagaagcta agcacattgc agaagaggca gataggaagt atgaagaggt    480

ggctcgtaag ttggtgatca ttgaaggaga cttggaacgc acagaggaac gagctgagct    540

ggcagagtct aagtgttctg agctggagga ggagctgaag aatgtcacca acaacctcaa    600

gtctcttgag gctcaggcgg agaagtactc tcaaaaagaa gataaatatg aggaagaaat    660

caagattctt actgataaac tcaaggaggc agagacccgt gctgagtttg ctgagagatc    720

ggtagccaag ctggaaaaga caattgatga cctggaagag cgtctctaca gccaacttga    780

gcgaaaccgc ctgctttcta atgagctgaa gctaacgctg catgatctgt gtgactgatg    840

ggcagggctc aatgatgccc attaaactga gcttactgct cacaccactg acctggaccc    900

caacaaaaag ctgattgtct ttttaaaagt tattattttg ccctgagcaa attgcatttt    960

aattggggca gttagaatgt tgatttccta acagcattgt gaagttgacc attgtgaagt   1020

ttctgtccct ttagaagaga ttatgggtga agaagggagg ggcctgagag attatagtga   1080

gaaaacttgc gagaattttg ttttccaccc ttatttgctg ctctttcact tgggcactga   1140

ctgtaggata tgttcccttg catggatgtt tttaacaata aaaggactga cttga        1195


<210>  1039
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  1039


Met Ala Gly Ile Thr Thr Ile Glu Ala Val Lys Arg Lys Ile Gln Val 
1               5                   10                  15      


Leu Gln Gln Gln Ala Asp Asp Ala Glu Glu Arg Ala Glu Arg Leu Gln 
            20                  25                  30          


Arg Glu Val Glu Gly Glu Arg Arg Ala Arg Glu Gln Ala Glu Ala Glu 
        35                  40                  45              


Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu Glu Glu Leu Asp 
    50                  55                  60                  


Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys Leu Glu Glu Ala 
65                  70                  75                  80  


Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys Val Ile Glu Asn 
                85                  90                  95      


Arg Ala Leu Lys Asp Glu Glu Lys Met Glu Leu Gln Glu Ile Gln Leu 
            100                 105                 110         


Lys Glu Ala Lys His Ile Ala Glu Glu Ala Asp Arg Lys Tyr Glu Glu 
        115                 120                 125             


Val Ala Arg Lys Leu Val Ile Ile Glu Gly Asp Leu Glu Arg Thr Glu 
    130                 135                 140                 


Glu Arg Ala Glu Leu Ala Glu Ser Lys Cys Ser Glu Leu Glu Glu Glu 
145                 150                 155                 160 


Leu Lys Asn Val Thr Asn Asn Leu Lys Ser Leu Glu Ala Gln Ala Glu 
                165                 170                 175     


Lys Tyr Ser Gln Lys Glu Asp Lys Tyr Glu Glu Glu Ile Lys Ile Leu 
            180                 185                 190         


Thr Asp Lys Leu Lys Glu Ala Glu Thr Arg Ala Glu Phe Ala Glu Arg 
        195                 200                 205             


Ser Val Ala Lys Leu Glu Lys Thr Ile Asp Asp Leu Glu Glu Arg Leu 
    210                 215                 220                 


Tyr Ser Gln Leu Glu Arg Asn Arg Leu Leu Ser Asn Glu Leu Lys Leu 
225                 230                 235                 240 


Thr Leu His Asp Leu Cys Asp 
                245         

<210>  1040
<211>  1704
<212>  DNA
<213>  Homo sapiens

<400>  1040
caggtagcag ttatgacttg ttcctggtag tggatttctc tcaagtgctt tattagtatt     60

caaacatttt tgagcccagg aaggtctagc tcctgacacg ttctatggta gagggaggag    120

ggttgatgct tgctcaggtt acttgggaac atctcttccc cagtatgcct tccaactctc    180

tctacatata ggttcaattc acgtctatgt gtctctctcc ctttttttat tctcttcctt    240

ttcccttttc ctctcctgtg gtatttaaaa tattcacagt aagtgttctg agctggagga    300

ggagctgaag aatgtcacca acaacctcaa gtctcttgag gctcaggcgg agaaggtagg    360

ggctggtttg tgaaagtgac aggctttggg gcctgggccc agccctgccc ttgatgaaag    420

actggagaca cgcattccat atataatcca gtgaggcgtg tcctcttcct acctccttac    480

catgtattca ggttctgggt ttaatgctat tttctgtgca ctttgattgc tttaattaaa    540

ataacttctt ggtctcaggt tactggagtc atgtgctcct taggctgata ctgctgtgct    600

gaaaagcaat aatcaagggc cctaacaggc tttctagcag acagatgggg gcaacagaca    660

gaatcagctc tgagacctaa tgagcaatca agacagatga cttcactttg ccatcatgtg    720

ggtgtgtttc agtcatgtga ccttggggtg ctactactct tgctcatcaa gcaggggaaa    780

ggaaaaacac ctccttgggt tgatctgaat aatatcaaag cttagatcca tcttaaaaag    840

tcatggagaa ttttaacctg aggatctcat ggctctaaag acatagattt ctgaatttca    900

aggacctatt gtccagagcc aggccttgct cttactcttg gaccattcag cacatttagt    960

gcaagaggat attcaatgta agttaaatgt agggaggggg gtattgcctg tgtgactaat   1020

ttctactctg aaatttttaa tctacttatc ttacagtact ctcaaaaaga agataaatat   1080

gaggaagaaa tcaagattct tactgataaa ctcaaggagg cagagacccg tgctgagttt   1140

gctgagagat cggtagccaa gctggaaaag acaattgatg acctggaaga tgagctctat   1200

gcccagaaac tgaagtacaa ggccattagc gaggagctgg accacgccct caatgacatg   1260

acctctatag cgtctctaca gccaacttga gcgaaaccgc ctgctttcta atgagctgaa   1320

gctaacgctg catgatctgt gtgactgatg ggcagggctc aatgatgccc attaaactga   1380

gcttactgct cacaccactg acctggaccc caacaaaaag ctgattgtct ttttaaaagt   1440

tattattttg ccctgagcaa attgcatttt aattggggca gttagaatgt tgatttccta   1500

acagcattgt gaagttgacc attgtgaagt ttctgtccct ttagaagaga ttatgggtga   1560

agaagggagg ggcctgagag attatagtga gaaaacttgc gagaattttg ttttccaccc   1620

ttatttgctg ctctttcact tgggcactga ctgtaggata tgttcccttg catggatgtt   1680

tttaacaata aaaggactga cttg                                          1704


<210>  1041
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  1041


Met Gly Glu Glu Gly Arg Gly Leu Arg Asp Tyr Ser Glu Lys Thr Cys 
1               5                   10                  15      


Glu Asn Phe Val Phe His Pro Tyr Leu Leu Leu Phe His Leu Gly Thr 
            20                  25                  30          


Asp Cys Arg Ile Cys Ser Leu Ala Trp Met Phe Leu Thr Ile Lys Gly 
        35                  40                  45              


Leu 
    

<210>  1042
<211>  747
<212>  DNA
<213>  Homo sapiens

<400>  1042
tgcagaagag gcagatagga agtatgaaga ggtggctcgt aagttggtga tcattgaagg     60

agacttggaa cgcacagagg aacgagctga gctggcagag tcccgttgcc gagagatgga    120

tgagcagatt agactgatgg accagaacct gaagtgtctg agtgctgctg aagaaaagta    180

ctctcaaaaa gaagataaat atgaggaaga aatcaagatt cttactgata aactcaagga    240

ggcagagacc cgtgctgagt ttgctgagag atcggtagcc aagctggaaa agacaattga    300

tgacctggaa gagcgtctct acagccaact tgagcgaaac cgcctgcttt ctaatgagct    360

gaagctaacg ctgcatgatc tgtgtgactg atgggcaggg ctcaatgatg cccattaaac    420

tgagcttact gctcacacca ctgacctgga ccccaacaaa aagctgattg tctttttaaa    480

agttattatt ttgccctgag caaattgcat tttaattggg gcagttagaa tgttgatttc    540

ctaacagcat tgtgaagttg accattgtga agtttctgtc cctttagaag agattatggg    600

tgaagaaggg aggggcctga gagattatag tgagaaaact tgcgagaatt ttgttttcca    660

cccttatttg ctgctctttc acttgggcac tgactgtagg atatgttccc ttgcatggat    720

gtttttaaca ataaaaggac tgacttg                                        747


<210>  1043
<211>  91
<212>  PRT
<213>  Homo sapiens

<400>  1043


Met Asp Glu Gln Ile Arg Leu Met Asp Gln Asn Leu Lys Cys Leu Ser 
1               5                   10                  15      


Ala Ala Glu Glu Lys Tyr Ser Gln Lys Glu Asp Lys Tyr Glu Glu Glu 
            20                  25                  30          


Ile Lys Ile Leu Thr Asp Lys Leu Lys Glu Ala Glu Thr Arg Ala Glu 
        35                  40                  45              


Phe Ala Glu Arg Ser Val Ala Lys Leu Glu Lys Thr Ile Asp Asp Leu 
    50                  55                  60                  


Glu Glu Arg Leu Tyr Ser Gln Leu Glu Arg Asn Arg Leu Leu Ser Asn 
65                  70                  75                  80  


Glu Leu Lys Leu Thr Leu His Asp Leu Cys Asp 
                85                  90      

<210>  1044
<211>  1230
<212>  DNA
<213>  Homo sapiens

<400>  1044
gtcacatccg ggcgggttgg tgagttccgg tatttcaggg cgtagcaggc ggaagtaagg     60

gtgagaggag gctgcaacgc cgagcggagg aggcaggaac cggagcgcga gcagtagctg    120

ggtgggcacc atggctggga tcaccaccat cgaggcggtg aagcgcaaga tccaggttct    180

gcagcagcag gcagatgatg cagaggagcg agctgagcgc ctccagcgag aagttgaggg    240

agaaaggcgg gcccgggaac aggctgaggc tgaggtggcc tccttgaacc gtaggatcca    300

gctggttgaa gaagagctgg accgtgctca ggagcgcctg gccactgccc tgcaaaagct    360

ggaagaagct gaaaaagctg ctgatgagag tgagagaggt atgaaggtta ttgaaaaccg    420

ggccttaaaa gatgaagaaa agatggaact ccaggaaatc caactcaaag aagctaagca    480

cattgcagaa gaggcagata ggaagtatga agaggtggct cgtaagttgg tgatcattga    540

aggagacttg gaacgcacag aggaacgagc tgagctggca gagtcccgtt gccgagagat    600

ggatgagcag attagactga tggaccagaa cctgaagtgt ctgagtgctg ctgaagaaaa    660

gtactctcaa aaagaagata aatatgagga agaaatcaag attcttactg ataaactcaa    720

ggaggcagag acccgtgctg agtttgctga gagatcggta gccaagctgg aaaagacaat    780

tgatgacctg gaagagcgtc tctacagcca acttgagcga aaccgcctgc tttctaatga    840

gctgaagcta acgctgcatg atctgtgtga ctgatgggca gggctcaatg atgcccatta    900

aactgagctt actgctcaca ccactgacct ggaccccaac aaaaagctga ttgtcttttt    960

aaaagttatt attttgccct gagcaaattg cattttaatt ggggcagtta gaatgttgat   1020

ttcctaacag cattgtgaag ttgaccattg tgaagtttct gtccctttag aagagattat   1080

gggtgaagaa gggaggggcc tgagagatta tagtgagaaa acttgcgaga attttgtttt   1140

ccacccttat ttgctgctct ttcacttggg cactgactgt aggatatgtt cccttgcatg   1200

gatgttttta acaataaaag gactgacttg                                    1230


<210>  1045
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  1045


Met Ala Gly Ile Thr Thr Ile Glu Ala Val Lys Arg Lys Ile Gln Val 
1               5                   10                  15      


Leu Gln Gln Gln Ala Asp Asp Ala Glu Glu Arg Ala Glu Arg Leu Gln 
            20                  25                  30          


Arg Glu Val Glu Gly Glu Arg Arg Ala Arg Glu Gln Ala Glu Ala Glu 
        35                  40                  45              


Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu Glu Glu Leu Asp 
    50                  55                  60                  


Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys Leu Glu Glu Ala 
65                  70                  75                  80  


Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys Val Ile Glu Asn 
                85                  90                  95      


Arg Ala Leu Lys Asp Glu Glu Lys Met Glu Leu Gln Glu Ile Gln Leu 
            100                 105                 110         


Lys Glu Ala Lys His Ile Ala Glu Glu Ala Asp Arg Lys Tyr Glu Glu 
        115                 120                 125             


Val Ala Arg Lys Leu Val Ile Ile Glu Gly Asp Leu Glu Arg Thr Glu 
    130                 135                 140                 


Glu Arg Ala Glu Leu Ala Glu Ser Arg Cys Arg Glu Met Asp Glu Gln 
145                 150                 155                 160 


Ile Arg Leu Met Asp Gln Asn Leu Lys Cys Leu Ser Ala Ala Glu Glu 
                165                 170                 175     


Lys Tyr Ser Gln Lys Glu Asp Lys Tyr Glu Glu Glu Ile Lys Ile Leu 
            180                 185                 190         


Thr Asp Lys Leu Lys Glu Ala Glu Thr Arg Ala Glu Phe Ala Glu Arg 
        195                 200                 205             


Ser Val Ala Lys Leu Glu Lys Thr Ile Asp Asp Leu Glu Glu Arg Leu 
    210                 215                 220                 


Tyr Ser Gln Leu Glu Arg Asn Arg Leu Leu Ser Asn Glu Leu Lys Leu 
225                 230                 235                 240 


Thr Leu His Asp Leu Cys Asp 
                245         

<210>  1046
<211>  2507
<212>  DNA
<213>  Homo sapiens

<400>  1046
caggtagcag ttatgacttg ttcctggtag tggatttctc tcaagtgctt tattagtatt     60

caaacatttt tgagcccagg aaggtctagc tcctgacacg ttctatggta gagggaggag    120

ggttgatgct tgctcaggtt acttgggaac atctcttccc cagtatgcct tccaactctc    180

tctacatata ggttcaattc acgtctatgt gtctctctcc ctttttttat tctcttcctt    240

ttcccttttc ctctcctgtg gtatttaaaa tattcacagt aagtgttctg agctggagga    300

ggagctgaag aatgtcacca acaacctcaa gtctcttgag gctcaggcgg agaaggtagg    360

ggctggtttg tgaaagtgac aggctttggg gcctgggccc agccctgccc ttgatgaaag    420

actggagaca cgcattccat atataatcca gtgaggcgtg tcctcttcct acctccttac    480

catgtattca ggttctgggt ttaatgctat tttctgtgca ctttgattgc tttaattaaa    540

ataacttctt ggtctcaggt tactggagtc atgtgctcct taggctgata ctgctgtgct    600

gaaaagcaat aatcaagggc cctaacaggc tttctagcag acagatgggg gcaacagaca    660

gaatcagctc tgagacctaa tgagcaatca agacagatga cttcactttg ccatcatgtg    720

ggtgtgtttc agtcatgtga ccttggggtg ctactactct tgctcatcaa gcaggggaaa    780

ggaaaaacac ctccttgggt tgatctgaat aatatcaaag cttagatcca tcttaaaaag    840

tcatggagaa ttttaacctg aggatctcat ggctctaaag acatagattt ctgaatttca    900

aggacctatt gtccagagcc aggccttgct cttactcttg gaccattcag cacatttagt    960

gcaagaggat attcaatgta agttaaatgt agggaggggg gtattgcctg tgtgactaat   1020

ttctactctg aaatttttaa tctacttatc ttacagtact ctcaaaaaga agataaatat   1080

gaggaagaaa tcaagattct tactgataaa ctcaaggagg cagagacccg tgctgagttt   1140

gctgagagat cggtagccaa gctggaaaag acaattgatg acctggaaga tgagctctat   1200

gcccagaaac tgaagtacaa ggccattagc gaggagctgg accacgccct caatgacatg   1260

acctctatat aattatcacc gtttctgctc tgttctggat ctgccccctt tactcctcgg   1320

ggaacccaag gccccactct cgctctggat tccatttggg tcagcctggc tggtccccaa   1380

ggcattagga tgggggagca aaaagcaact tatgtatttt cttccacccc caccccaaat   1440

taaaatgtta agctgctgga aacctcatgc caccctgcat ttgtgtcatt gacaaagctg   1500

ttgctgtccc taagaaggag ccttgggggt gtgatgtggg gaagagctat tgtaggctcc   1560

ccctcctctg acttatgtaa tcaaagccac ttttgtgtgt gtctattttt tcttgacatt   1620

taaactcagc tgatctgatt ctaccagagt gatggattta gtacaggtta ctcaggatag   1680

taattttagt tatactcctc aagctgaaca agattaaatt ccttatttcc aggttcttaa   1740

atcatcctgc ctgcagtgtt tccattctct cttcaggtat tcctcctttg gtgtggtgtc   1800

attgagaagc cattgaagtg actctcaata cacattctgt acccttttac cggtggttca   1860

aatggtgcat cctcagaaca cccagtgaac ccaatacatt attgctaaga ttgactaatt   1920

atgtcaactc cagtcacaga aaaatacaca atggatagaa ttctggacgg tttttttact   1980

ttttcttctt taaacctttc ttacatattt gagacttgct accatttgcc tgctagtgtg   2040

tgactagtgg gatataagat aagtgataaa ttattattgg gaaaactaaa atgaccaatc   2100

atgcatattt caaataatgt gcatatgagg ctaatgattt attacataca taaatttctg   2160

ctagtaaaat tttccttggt tcatattgtg gaattaaata tcaacatttt agaaattccc   2220

attataggcc gggcgtggta gctcacgcct ataatcccag cactttggga ggctggggca   2280

ggtggatcac ctgaggtcat gagttcgaga ccagctcggc caacatggtg aaaccccgtc   2340

tctactaaaa atacaaaaat tagctgggca tggtgggtgg gtgcctgtaa tcccagctac   2400

tcgggaggct gaggcaggag aatcgcttgc acctgggagg cggaggttgc agtgagcgga   2460

gatcgcgcca ctgcattcca gcctgggcaa cagagagact ccatctc                 2507


<210>  1047
<211>  46
<212>  PRT
<213>  Homo sapiens

<400>  1047


Met His Ile Ser Asn Asn Val His Met Arg Leu Met Ile Tyr Tyr Ile 
1               5                   10                  15      


His Lys Phe Leu Leu Val Lys Phe Ser Leu Val His Ile Val Glu Leu 
            20                  25                  30          


Asn Ile Asn Ile Leu Glu Ile Pro Ile Ile Gly Arg Ala Trp 
        35                  40                  45      

<210>  1048
<211>  1667
<212>  DNA
<213>  Homo sapiens

<400>  1048
gaactccagg aaatccaact caaagaagct aagcacattg cagaagaggc agataggaag     60

tatgaagagg tggctcgtaa gttggtgatc attgaaggag acttggaacg cacagaggaa    120

cgagctgagc tggcagagtc taagtgttct gagctggagg aggagctgaa gaatgtcacc    180

aacaacctca agtctcttga ggctcaggcg gagaagtact ctcaaaaaga agataaatat    240

gaggaagaaa tcaagattct tactgataaa ctcaaggagg cagagacccg tgctgagttt    300

gctgagagat cggtagccaa gctggaaaag acaattgatg acctggaaga tgagctctat    360

gcccagaaac tgaagtacaa ggccattagc gaggagctgg accacgccct caatgacatg    420

acctctatat aattatcacc gtttctgctc tgttctggat ctgccccctt tactcctcgg    480

ggaacccaag gccccactct cgctctggat tccatttggg tcagcctggc tggtccccaa    540

ggcattagga tgggggagca aaaagcaact tatgtatttt cttccacccc caccccaaat    600

taaaatgtta agctgctgga aacctcatgc caccctgcat ttgtgtcatt gacaaagctg    660

ttgctgtccc taagaaggag ccttgggggt gtgatgtggg gaagagctat tgtaggctcc    720

ccctcctctg acttatgtaa tcaaagccac ttttgtgtgt gtctattttt tcttgacatt    780

taaactcagc tgatctgatt ctaccagagt gatggattta gtacaggtta ctcaggatag    840

taattttagt tatactcctc aagctgaaca agattaaatt ccttatttcc aggttcttaa    900

atcatcctgc ctgcagtgtt tccattctct cttcaggtat tcctcctttg gtgtggtgtc    960

attgagaagc cattgaagtg actctcaata cacattctgt acccttttac cggtggttca   1020

aatggtgcat cctcagaaca cccagtgaac ccaatacatt attgctaaga ttgactaatt   1080

atgtcaactc cagtcacaga aaaatacaca atggatagaa ttctggacgg tttttttact   1140

ttttcttctt taaacctttc ttacatattt gagacttgct accatttgcc tgctagtgtg   1200

tgactagtgg gatataagat aagtgataaa ttattattgg gaaaactaaa atgaccaatc   1260

atgcatattt caaataatgt gcatatgagg ctaatgattt attacataca taaatttctg   1320

ctagtaaaat tttccttggt tcatattgtg gaattaaata tcaacatttt agaaattccc   1380

attataggcc gggcgtggta gctcacgcct ataatcccag cactttggga ggctggggca   1440

ggtggatcac ctgaggtcat gagttcgaga ccagctcggc caacatggtg aaaccccgtc   1500

tctactaaaa atacaaaaat tagctgggca tggtgggtgg gtgcctgtaa tcccagctac   1560

tcgggaggct gaggcaggag aatcgcttgc acctgggagg cggaggttgc agtgagcgga   1620

gatcgcgcca ctgcattcca gcctgggcaa cagagagact ccatctc                 1667


<210>  1049
<211>  47
<212>  PRT
<213>  Homo sapiens

<400>  1049


Met Ser Pro Thr Thr Ser Ser Leu Leu Arg Leu Arg Arg Arg Ser Thr 
1               5                   10                  15      


Leu Lys Lys Lys Ile Asn Met Arg Lys Lys Ser Arg Phe Leu Leu Ile 
            20                  25                  30          


Asn Ser Arg Arg Gln Arg Pro Val Leu Ser Leu Leu Arg Asp Arg 
        35                  40                  45          

<210>  1050
<211>  2051
<212>  DNA
<213>  Homo sapiens

<400>  1050
cactcaggca gcagcccctt ctttcttgcc ccagtctcca gttctccagt gttcacaggt     60

gagcctacca acagccactg ctcatgatgg aggccatcaa gaaaaagatg cagatgctga    120

agttagacaa ggagaatgct ctggatcggg cagagcaagc tgaagctgag cagaagcagg    180

cagaagaaag aagtaaacag ctggaggatg agctggcagc catgcagaag aagctgaaag    240

ggacagagga tgaagctgga ccgtgctcag gagcgcctgg ccactgccct gcaaaagctg    300

gaagaagctg aaaaagctgc tgatgagagt gagagaggta tgaaggttat tgaaaaccgg    360

gccttaaaag atgaagaaaa gatggaactc caggaaatcc aactcaaaga agctaagcac    420

attgcagaag aggcagatag gaagtatgaa gaggtggctc gtaagttggt gatcattgaa    480

ggagacttgg aacgcacaga ggaacgagct gagctggcag agtctaagtg ttctgagctg    540

gaggaggagc tgaagaatgt caccaacaac ctcaagtctc ttgaggctca ggcggagaag    600

tactctcaaa aagaagataa atatgaggaa gaaatcaaga ttcttactga taaactcaag    660

gaggcagaga cccgtgctga gtttgctgag agatcggtag ccaagctgga aaagacaatt    720

gatgacctgg aagatgagct ctatgcccag aaactgaagt acaaggccat tagcgaggag    780

ctggaccacg ccctcaatga catgacctct atataattat caccgtttct gctctgttct    840

ggatctgccc cctttactcc tcggggaacc caaggcccca ctctcgctct ggattccatt    900

tgggtcagcc tggctggtcc ccaaggcatt aggatggggg agcaaaaagc aacttatgta    960

ttttcttcca cccccacccc aaattaaaat gttaagctgc tggaaacctc atgccaccct   1020

gcatttgtgt cattgacaaa gctgttgctg tccctaagaa ggagccttgg gggtgtgatg   1080

tggggaagag ctattgtagg ctccccctcc tctgacttat gtaatcaaag ccacttttgt   1140

gtgtgtctat tttttcttga catttaaact cagctgatct gattctacca gagtgatgga   1200

tttagtacag gttactcagg atagtaattt tagttatact cctcaagctg aacaagatta   1260

aattccttat ttccaggttc ttaaatcatc ctgcctgcag tgtttccatt ctctcttcag   1320

gtattcctcc tttggtgtgg tgtcattgag aagccattga agtgactctc aatacacatt   1380

ctgtaccctt ttaccggtgg ttcaaatggt gcatcctcag aacacccagt gaacccaata   1440

cattattgct aagattgact aattatgtca actccagtca cagaaaaata cacaatggat   1500

agaattctgg acggtttttt tactttttct tctttaaacc tttcttacat atttgagact   1560

tgctaccatt tgcctgctag tgtgtgacta gtgggatata agataagtga taaattatta   1620

ttgggaaaac taaaatgacc aatcatgcat atttcaaata atgtgcatat gaggctaatg   1680

atttattaca tacataaatt tctgctagta aaattttcct tggttcatat tgtggaatta   1740

aatatcaaca ttttagaaat tcccattata ggccgggcgt ggtagctcac gcctataatc   1800

ccagcacttt gggaggctgg ggcaggtgga tcacctgagg tcatgagttc gagaccagct   1860

cggccaacat ggtgaaaccc cgtctctact aaaaatacaa aaattagctg ggcatggtgg   1920

gtgggtgcct gtaatcccag ctactcggga ggctgaggca ggagaatcgc ttgcacctgg   1980

gaggcggagg ttgcagtgag cggagatcgc gccactgcat tccagcctgg gcaacagaga   2040

gactccatct c                                                        2051


<210>  1051
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  1051


Met Lys Leu Asp Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys 
1               5                   10                  15      


Leu Glu Glu Ala Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys 
            20                  25                  30          


Val Ile Glu Asn Arg Ala Leu Lys Asp Glu Glu Lys Met Glu Leu Gln 
        35                  40                  45              


Glu Ile Gln Leu Lys Glu Ala Lys His Ile Ala Glu Glu Ala Asp Arg 
    50                  55                  60                  


Lys Tyr Glu Glu Val Ala Arg Lys Leu Val Ile Ile Glu Gly Asp Leu 
65                  70                  75                  80  


Glu Arg Thr Glu Glu Arg Ala Glu Leu Ala Glu Ser Lys Cys Ser Glu 
                85                  90                  95      


Leu Glu Glu Glu Leu Lys Asn Val Thr Asn Asn Leu Lys Ser Leu Glu 
            100                 105                 110         


Ala Gln Ala Glu Lys Tyr Ser Gln Lys Glu Asp Lys Tyr Glu Glu Glu 
        115                 120                 125             


Ile Lys Ile Leu Thr Asp Lys Leu Lys Glu Ala Glu Thr Arg Ala Glu 
    130                 135                 140                 


Phe Ala Glu Arg Ser Val Ala Lys Leu Glu Lys Thr Ile Asp Asp Leu 
145                 150                 155                 160 


Glu Asp Glu Leu Tyr Ala Gln Lys Leu Lys Tyr Lys Ala Ile Ser Glu 
                165                 170                 175     


Glu Leu Asp His Ala Leu Asn Asp Met Thr Ser Ile 
            180                 185             

<210>  1052
<211>  2001
<212>  DNA
<213>  Homo sapiens

<400>  1052
agataaagac tcaagtctgg ggacctcctg gtcactcagg cagcagcccc ttctttcttg     60

ccccagtctc cagttctcca gtgttcacag gtgagcctac caacagccac tgctcatgat    120

ggaggccatc aagaaaaaga tgcagatgct gaagttagac aaggagaatg ctctggatcg    180

ggcagagcaa gctgaagctg agcagaagca ggcagaagaa agaagtaaac agctggagga    240

tgagctggca gccatgcaga agaagctgaa agggacagag gatgaaggta tgaaggttat    300

tgaaaaccgg gccttaaaag atgaagaaaa gatggaactc caggaaatcc aactcaaaga    360

agctaagcac attgcagaag aggcagatag gaagtatgaa gaggtggctc gtaagttggt    420

gatcattgaa ggagacttgg aacgcacaga ggaacgagct gagctggcag agtctaagtg    480

ttctgagctg gaggaggagc tgaagaatgt caccaacaac ctcaagtctc ttgaggctca    540

ggcggagaag tactctcaaa aagaagataa atatgaggaa gaaatcaaga ttcttactga    600

taaactcaag gaggcagaga cccgtgctga gtttgctgag agatcggtag ccaagctgga    660

aaagacaatt gatgacctgg aagatgagct ctatgcccag aaactgaagt acaaggccat    720

tagcgaggag ctggaccacg ccctcaatga catgacctct atataattat caccgtttct    780

gctctgttct ggatctgccc cctttactcc tcggggaacc caaggcccca ctctcgctct    840

ggattccatt tgggtcagcc tggctggtcc ccaaggcatt aggatggggg agcaaaaagc    900

aacttatgta ttttcttcca cccccacccc aaattaaaat gttaagctgc tggaaacctc    960

atgccaccct gcatttgtgt cattgacaaa gctgttgctg tccctaagaa ggagccttgg   1020

gggtgtgatg tggggaagag ctattgtagg ctccccctcc tctgacttat gtaatcaaag   1080

ccacttttgt gtgtgtctat tttttcttga catttaaact cagctgatct gattctacca   1140

gagtgatgga tttagtacag gttactcagg atagtaattt tagttatact cctcaagctg   1200

aacaagatta aattccttat ttccaggttc ttaaatcatc ctgcctgcag tgtttccatt   1260

ctctcttcag gtattcctcc tttggtgtgg tgtcattgag aagccattga agtgactctc   1320

aatacacatt ctgtaccctt ttaccggtgg ttcaaatggt gcatcctcag aacacccagt   1380

gaacccaata cattattgct aagattgact aattatgtca actccagtca cagaaaaata   1440

cacaatggat agaattctgg acggtttttt tactttttct tctttaaacc tttcttacat   1500

atttgagact tgctaccatt tgcctgctag tgtgtgacta gtgggatata agataagtga   1560

taaattatta ttgggaaaac taaaatgacc aatcatgcat atttcaaata atgtgcatat   1620

gaggctaatg atttattaca tacataaatt tctgctagta aaattttcct tggttcatat   1680

tgtggaatta aatatcaaca ttttagaaat tcccattata ggccgggcgt ggtagctcac   1740

gcctataatc ccagcacttt gggaggctgg ggcaggtgga tcacctgagg tcatgagttc   1800

gagaccagct cggccaacat ggtgaaaccc cgtctctact aaaaatacaa aaattagctg   1860

ggcatggtgg gtgggtgcct gtaatcccag ctactcggga ggctgaggca ggagaatcgc   1920

ttgcacctgg gaggcggagg ttgcagtgag cggagatcgc gccactgcat tccagcctgg   1980

gcaacagaga gactccatct c                                             2001


<210>  1053
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  1053


Met Met Glu Ala Ile Lys Lys Lys Met Gln Met Leu Lys Leu Asp Lys 
1               5                   10                  15      


Glu Asn Ala Leu Asp Arg Ala Glu Gln Ala Glu Ala Glu Gln Lys Gln 
            20                  25                  30          


Ala Glu Glu Arg Ser Lys Gln Leu Glu Asp Glu Leu Ala Ala Met Gln 
        35                  40                  45              


Lys Lys Leu Lys Gly Thr Glu Asp Glu Gly Met Lys Val Ile Glu Asn 
    50                  55                  60                  


Arg Ala Leu Lys Asp Glu Glu Lys Met Glu Leu Gln Glu Ile Gln Leu 
65                  70                  75                  80  


Lys Glu Ala Lys His Ile Ala Glu Glu Ala Asp Arg Lys Tyr Glu Glu 
                85                  90                  95      


Val Ala Arg Lys Leu Val Ile Ile Glu Gly Asp Leu Glu Arg Thr Glu 
            100                 105                 110         


Glu Arg Ala Glu Leu Ala Glu Ser Lys Cys Ser Glu Leu Glu Glu Glu 
        115                 120                 125             


Leu Lys Asn Val Thr Asn Asn Leu Lys Ser Leu Glu Ala Gln Ala Glu 
    130                 135                 140                 


Lys Tyr Ser Gln Lys Glu Asp Lys Tyr Glu Glu Glu Ile Lys Ile Leu 
145                 150                 155                 160 


Thr Asp Lys Leu Lys Glu Ala Glu Thr Arg Ala Glu Phe Ala Glu Arg 
                165                 170                 175     


Ser Val Ala Lys Leu Glu Lys Thr Ile Asp Asp Leu Glu Asp Glu Leu 
            180                 185                 190         


Tyr Ala Gln Lys Leu Lys Tyr Lys Ala Ile Ser Glu Glu Leu Asp His 
        195                 200                 205             


Ala Leu Asn Asp Met Thr Ser Ile 
    210                 215     

<210>  1054
<211>  2286
<212>  DNA
<213>  Homo sapiens

<400>  1054
gttcccccag gagaacaatg atggggtgga gggagctgga aagaccatat taggaacaaa     60

aggtggagct atgagcacag ataaagactc aagtctgggg acctcctggt cactcaggca    120

gcagcccctt ctttcttgcc ccagtctcca gttctccagt gttcacaggt gagcctacca    180

acagccactg ctcatgatgg aggccatcaa gaaaaagatg cagatgctga agttagacaa    240

ggagaatgct ctggatcggg cagagcaagc tgaagctgag cagaagcagg cagaagaaag    300

aagtaaacag ctggaggatg agctggcagc catgcagaag aagctgaaag ggacagagga    360

tgagctggac aagtattctg aagctttgaa ggatgcccag gagaagctgg aactggcaga    420

gaagaaggct gctgatgctg aggctgaggt ggcctccttg aaccgtagga tccagctggt    480

tgaagaagag ctggaccgtg ctcaggagcg cctggccact gccctgcaaa agctggaaga    540

agctgaaaaa gctgctgatg agagtgagag aggtatgaag gttattgaaa accgggcctt    600

aaaagatgaa gaaaagatgg aactccagga aatccaactc aaagaagcta agcacattgc    660

agaagaggca gataggaagt atgaagaggt ggctcgtaag ttggtgatca ttgaaggaga    720

cttggaacgc acagaggaac gagctgagct ggcagagtct aagtgttctg agctggagga    780

ggagctgaag aatgtcacca acaacctcaa gtctcttgag gctcaggcgg agaagtactc    840

tcaaaaagaa gataaatatg aggaagaaat caagattctt actgataaac tcaaggaggc    900

agagacccgt gctgagtttg ctgagagatc ggtagccaag ctggaaaaga caattgatga    960

cctggaagat gagctctatg cccagaaact gaagtacaag gccattagcg aggagctgga   1020

ccacgccctc aatgacatga cctctatata attatcaccg tttctgctct gttctggatc   1080

tgcccccttt actcctcggg gaacccaagg ccccactctc gctctggatt ccatttgggt   1140

cagcctggct ggtccccaag gcattaggat gggggagcaa aaagcaactt atgtattttc   1200

ttccaccccc accccaaatt aaaatgttaa gctgctggaa acctcatgcc accctgcatt   1260

tgtgtcattg acaaagctgt tgctgtccct aagaaggagc cttgggggtg tgatgtgggg   1320

aagagctatt gtaggctccc cctcctctga cttatgtaat caaagccact tttgtgtgtg   1380

tctatttttt cttgacattt aaactcagct gatctgattc taccagagtg atggatttag   1440

tacaggttac tcaggatagt aattttagtt atactcctca agctgaacaa gattaaattc   1500

cttatttcca ggttcttaaa tcatcctgcc tgcagtgttt ccattctctc ttcaggtatt   1560

cctcctttgg tgtggtgtca ttgagaagcc attgaagtga ctctcaatac acattctgta   1620

cccttttacc ggtggttcaa atggtgcatc ctcagaacac ccagtgaacc caatacatta   1680

ttgctaagat tgactaatta tgtcaactcc agtcacagaa aaatacacaa tggatagaat   1740

tctggacggt ttttttactt tttcttcttt aaacctttct tacatatttg agacttgcta   1800

ccatttgcct gctagtgtgt gactagtggg atataagata agtgataaat tattattggg   1860

aaaactaaaa tgaccaatca tgcatatttc aaataatgtg catatgaggc taatgattta   1920

ttacatacat aaatttctgc tagtaaaatt ttccttggtt catattgtgg aattaaatat   1980

caacatttta gaaattccca ttataggccg ggcgtggtag ctcacgccta taatcccagc   2040

actttgggag gctggggcag gtggatcacc tgaggtcatg agttcgagac cagctcggcc   2100

aacatggtga aaccccgtct ctactaaaaa tacaaaaatt agctgggcat ggtgggtggg   2160

tgcctgtaat cccagctact cgggaggctg aggcaggaga atcgcttgca cctgggaggc   2220

ggaggttgca gtgagcggag atcgcgccac tgcattccag cctgggcaac agagagactc   2280

catctc                                                              2286


<210>  1055
<211>  285
<212>  PRT
<213>  Homo sapiens

<400>  1055


Met Met Glu Ala Ile Lys Lys Lys Met Gln Met Leu Lys Leu Asp Lys 
1               5                   10                  15      


Glu Asn Ala Leu Asp Arg Ala Glu Gln Ala Glu Ala Glu Gln Lys Gln 
            20                  25                  30          


Ala Glu Glu Arg Ser Lys Gln Leu Glu Asp Glu Leu Ala Ala Met Gln 
        35                  40                  45              


Lys Lys Leu Lys Gly Thr Glu Asp Glu Leu Asp Lys Tyr Ser Glu Ala 
    50                  55                  60                  


Leu Lys Asp Ala Gln Glu Lys Leu Glu Leu Ala Glu Lys Lys Ala Ala 
65                  70                  75                  80  


Asp Ala Glu Ala Glu Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val 
                85                  90                  95      


Glu Glu Glu Leu Asp Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln 
            100                 105                 110         


Lys Leu Glu Glu Ala Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met 
        115                 120                 125             


Lys Val Ile Glu Asn Arg Ala Leu Lys Asp Glu Glu Lys Met Glu Leu 
    130                 135                 140                 


Gln Glu Ile Gln Leu Lys Glu Ala Lys His Ile Ala Glu Glu Ala Asp 
145                 150                 155                 160 


Arg Lys Tyr Glu Glu Val Ala Arg Lys Leu Val Ile Ile Glu Gly Asp 
                165                 170                 175     


Leu Glu Arg Thr Glu Glu Arg Ala Glu Leu Ala Glu Ser Lys Cys Ser 
            180                 185                 190         


Glu Leu Glu Glu Glu Leu Lys Asn Val Thr Asn Asn Leu Lys Ser Leu 
        195                 200                 205             


Glu Ala Gln Ala Glu Lys Tyr Ser Gln Lys Glu Asp Lys Tyr Glu Glu 
    210                 215                 220                 


Glu Ile Lys Ile Leu Thr Asp Lys Leu Lys Glu Ala Glu Thr Arg Ala 
225                 230                 235                 240 


Glu Phe Ala Glu Arg Ser Val Ala Lys Leu Glu Lys Thr Ile Asp Asp 
                245                 250                 255     


Leu Glu Asp Glu Leu Tyr Ala Gln Lys Leu Lys Tyr Lys Ala Ile Ser 
            260                 265                 270         


Glu Glu Leu Asp His Ala Leu Asn Asp Met Thr Ser Ile 
        275                 280                 285 

<210>  1056
<211>  1466
<212>  DNA
<213>  Homo sapiens

<400>  1056
caggtagcag ttatgacttg ttcctggtag tggatttctc tcaagtgctt tattagtatt     60

caaacatttt tgagcccagg aaggtctagc tcctgacacg ttctatggta gagggaggag    120

ggttgatgct tgctcaggtt acttgggaac atctcttccc cagtatgcct tccaactctc    180

tctacatata ggttcaattc acgtctatgt gtctctctcc ctttttttat tctcttcctt    240

ttcccttttc ctctcctgtg gtatttaaaa tattcacagt aagtgttctg agctggagga    300

ggagctgaag aatgtcacca acaacctcaa gtctcttgag gctcaggcgg agaaggtagg    360

ggctggtttg tgaaagtgac aggctttggg gcctgggccc agccctgccc ttgatgaaag    420

actggagaca cgcattccat atataatcca gtgaggcgtg tcctcttcct acctccttac    480

catgtattca ggttctgggt ttaatgctat tttctgtgca ctttgattgc tttaattaaa    540

ataacttctt ggtctcaggt tactggagtc atgtgctcct taggctgata ctgctgtgct    600

gaaaagcaat aatcaagggc cctaacaggc tttctagcag acagatgggg gcaacagaca    660

gaatcagctc tgagacctaa tgagcaatca agacagatga cttcactttg ccatcatgtg    720

ggtgtgtttc agtcatgtga ccttggggtg ctactactct tgctcatcaa gcaggggaaa    780

ggaaaaacac ctccttgggt tgatctgaat aatatcaaag cttagatcca tcttaaaaag    840

tcatggagaa ttttaacctg aggatctcat ggctctaaag acatagattt ctgaatttca    900

aggacctatt gtccagagcc aggccttgct cttactcttg gaccattcag cacatttagt    960

gcaagaggat attcaatgta agttaaatgt agggaggggg gtattgcctg tgtgactaat   1020

ttctactctg aaatttttaa tctacttatc ttacagtact ctcaaaaaga agataaatat   1080

gaggaagaaa tcaagattct tactgataaa ctcaaggagg cagagacccg tgctgagttt   1140

gctgagagat cggtagccaa gctggaaaag acaattgatg acctggaaga tgagctctat   1200

gcccagaaac tgaagtacaa ggccattagc gaggagctgg accacgccct caatgacatg   1260

acctctatat aattatcacc gtttctgctc tgttctggat ctgccccctt tactcctcgg   1320

ggaacccaag gccccactct cgctctggat tccatttggg tcagcctggc tggtccccaa   1380

ggcattagga tgggggagca aaaagcaact tatgtatttt cttccacccc caccccaaat   1440

taaaatgtta agctgctgga aacctc                                        1466


<210>  1057
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  1057


Met Thr Ser Leu Cys His His Val Gly Val Phe Gln Ser Cys Asp Leu 
1               5                   10                  15      


Gly Val Leu Leu Leu Leu Leu Ile Lys Gln Gly Lys Gly Lys Thr Pro 
            20                  25                  30          


Pro Trp Val Asp Leu Asn Asn Ile Lys Ala 
        35                  40          

<210>  1058
<211>  626
<212>  DNA
<213>  Homo sapiens

<400>  1058
gaactccagg aaatccaact caaagaagct aagcacattg cagaagaggc agataggaag     60

tatgaagagg tggctcgtaa gttggtgatc attgaaggag acttggaacg cacagaggaa    120

cgagctgagc tggcagagtc taagtgttct gagctggagg aggagctgaa gaatgtcacc    180

aacaacctca agtctcttga ggctcaggcg gagaagtact ctcaaaaaga agataaatat    240

gaggaagaaa tcaagattct tactgataaa ctcaaggagg cagagacccg tgctgagttt    300

gctgagagat cggtagccaa gctggaaaag acaattgatg acctggaaga tgagctctat    360

gcccagaaac tgaagtacaa ggccattagc gaggagctgg accacgccct caatgacatg    420

acctctatat aattatcacc gtttctgctc tgttctggat ctgccccctt tactcctcgg    480

ggaacccaag gccccactct cgctctggat tccatttggg tcagcctggc tggtccccaa    540

ggcattagga tgggggagca aaaagcaact tatgtatttt cttccacccc caccccaaat    600

taaaatgtta agctgctgga aacctc                                         626


<210>  1059
<211>  47
<212>  PRT
<213>  Homo sapiens

<400>  1059


Met Ser Pro Thr Thr Ser Ser Leu Leu Arg Leu Arg Arg Arg Ser Thr 
1               5                   10                  15      


Leu Lys Lys Lys Ile Asn Met Arg Lys Lys Ser Arg Phe Leu Leu Ile 
            20                  25                  30          


Asn Ser Arg Arg Gln Arg Pro Val Leu Ser Leu Leu Arg Asp Arg 
        35                  40                  45          

<210>  1060
<211>  1000
<212>  DNA
<213>  Homo sapiens

<400>  1060
actcaggcag cagccccttc tttcttgccc cagtctccag ttctccagtg ttcacaggtg     60

agcctaccaa cagccactgc tcatgatgga ggccatcaag aaaaagatgc agatgctgaa    120

gttagacaag gagaatgctc tggatcgggc agagcaagct gaagctgagc agaagcaggc    180

agaagaaaga agtaaacagc tggaggatga gctggcagcc atgcagaaga agctgaaagg    240

gacagaggat gagctggaca agtattctga agctttgaag gatgcccagg agaaaagctg    300

aaaaagctgc tgatgagagt gagagaggta tgaaggttat tgaaaaccgg gccttaaaag    360

atgaagaaaa gatggaactc caggaaatcc aactcaaaga agctaagcac attgcagaag    420

aggcagatag gaagtatgaa gaggtggctc gtaagttggt gatcattgaa ggagacttgg    480

aacgcacaga ggaacgagct gagctggcag agtctaagtg ttctgagctg gaggaggagc    540

tgaagaatgt caccaacaac ctcaagtctc ttgaggctca ggcggagaag tactctcaaa    600

aagaagataa atatgaggaa gaaatcaaga ttcttactga taaactcaag gaggcagaga    660

cccgtgctga gtttgctgag agatcggtag ccaagctgga aaagacaatt gatgacctgg    720

aagatgagct ctatgcccag aaactgaagt acaaggccat tagcgaggag ctggaccacg    780

ccctcaatga catgacctct atataattat caccgtttct gctctgttct ggatctgccc    840

cctttactcc tcggggaacc caaggcccca ctctcgctct ggattccatt tgggtcagcc    900

tggctggtcc ccaaggcatt aggatggggg agcaaaaagc aacttatgta ttttcttcca    960

cccccacccc aaattaaaat gttaagctgc tggaaacctc                         1000


<210>  1061
<211>  174
<212>  PRT
<213>  Homo sapiens

<400>  1061


Met Pro Arg Arg Lys Ala Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly 
1               5                   10                  15      


Met Lys Val Ile Glu Asn Arg Ala Leu Lys Asp Glu Glu Lys Met Glu 
            20                  25                  30          


Leu Gln Glu Ile Gln Leu Lys Glu Ala Lys His Ile Ala Glu Glu Ala 
        35                  40                  45              


Asp Arg Lys Tyr Glu Glu Val Ala Arg Lys Leu Val Ile Ile Glu Gly 
    50                  55                  60                  


Asp Leu Glu Arg Thr Glu Glu Arg Ala Glu Leu Ala Glu Ser Lys Cys 
65                  70                  75                  80  


Ser Glu Leu Glu Glu Glu Leu Lys Asn Val Thr Asn Asn Leu Lys Ser 
                85                  90                  95      


Leu Glu Ala Gln Ala Glu Lys Tyr Ser Gln Lys Glu Asp Lys Tyr Glu 
            100                 105                 110         


Glu Glu Ile Lys Ile Leu Thr Asp Lys Leu Lys Glu Ala Glu Thr Arg 
        115                 120                 125             


Ala Glu Phe Ala Glu Arg Ser Val Ala Lys Leu Glu Lys Thr Ile Asp 
    130                 135                 140                 


Asp Leu Glu Asp Glu Leu Tyr Ala Gln Lys Leu Lys Tyr Lys Ala Ile 
145                 150                 155                 160 


Ser Glu Glu Leu Asp His Ala Leu Asn Asp Met Thr Ser Ile 
                165                 170                 

<210>  1062
<211>  1245
<212>  DNA
<213>  Homo sapiens

<400>  1062
gttcccccag gagaacaatg atggggtgga gggagctgga aagaccatat taggaacaaa     60

aggtggagct atgagcacag ataaagactc aagtctgggg acctcctggt cactcaggca    120

gcagcccctt ctttcttgcc ccagtctcca gttctccagt gttcacaggt gagcctacca    180

acagccactg ctcatgatgg aggccatcaa gaaaaagatg cagatgctga agttagacaa    240

ggagaatgct ctggatcggg cagagcaagc tgaagctgag cagaagcagg cagaagaaag    300

aagtaaacag ctggaggatg agctggcagc catgcagaag aagctgaaag ggacagagga    360

tgagctggac aagtattctg aagctttgaa ggatgcccag gagaagctgg aactggcaga    420

gaagaaggct gctgatgctg aggctgaggt ggcctccttg aaccgtagga tccagctggt    480

tgaagaagag ctggaccgtg ctcaggagcg cctggccact gccctgcaaa agctggaaga    540

agctgaaaaa gctgctgatg agagtgagag aggtatgaag gttattgaaa accgggcctt    600

aaaagatgaa gaaaagatgg aactccagga aatccaactc aaagaagcta agcacattgc    660

agaagaggca gataggaagt atgaagaggt ggctcgtaag ttggtgatca ttgaaggaga    720

cttggaacgc acagaggaac gagctgagct ggcagagtct aagtgttctg agctggagga    780

ggagctgaag aatgtcacca acaacctcaa gtctcttgag gctcaggcgg agaagtactc    840

tcaaaaagaa gataaatatg aggaagaaat caagattctt actgataaac tcaaggaggc    900

agagacccgt gctgagtttg ctgagagatc ggtagccaag ctggaaaaga caattgatga    960

cctggaagat gagctctatg cccagaaact gaagtacaag gccattagcg aggagctgga   1020

ccacgccctc aatgacatga cctctatata attatcaccg tttctgctct gttctggatc   1080

tgcccccttt actcctcggg gaacccaagg ccccactctc gctctggatt ccatttgggt   1140

cagcctggct ggtccccaag gcattaggat gggggagcaa aaagcaactt atgtattttc   1200

ttccaccccc accccaaatt aaaatgttaa gctgctggaa acctc                   1245


<210>  1063
<211>  285
<212>  PRT
<213>  Homo sapiens

<400>  1063


Met Met Glu Ala Ile Lys Lys Lys Met Gln Met Leu Lys Leu Asp Lys 
1               5                   10                  15      


Glu Asn Ala Leu Asp Arg Ala Glu Gln Ala Glu Ala Glu Gln Lys Gln 
            20                  25                  30          


Ala Glu Glu Arg Ser Lys Gln Leu Glu Asp Glu Leu Ala Ala Met Gln 
        35                  40                  45              


Lys Lys Leu Lys Gly Thr Glu Asp Glu Leu Asp Lys Tyr Ser Glu Ala 
    50                  55                  60                  


Leu Lys Asp Ala Gln Glu Lys Leu Glu Leu Ala Glu Lys Lys Ala Ala 
65                  70                  75                  80  


Asp Ala Glu Ala Glu Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val 
                85                  90                  95      


Glu Glu Glu Leu Asp Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln 
            100                 105                 110         


Lys Leu Glu Glu Ala Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met 
        115                 120                 125             


Lys Val Ile Glu Asn Arg Ala Leu Lys Asp Glu Glu Lys Met Glu Leu 
    130                 135                 140                 


Gln Glu Ile Gln Leu Lys Glu Ala Lys His Ile Ala Glu Glu Ala Asp 
145                 150                 155                 160 


Arg Lys Tyr Glu Glu Val Ala Arg Lys Leu Val Ile Ile Glu Gly Asp 
                165                 170                 175     


Leu Glu Arg Thr Glu Glu Arg Ala Glu Leu Ala Glu Ser Lys Cys Ser 
            180                 185                 190         


Glu Leu Glu Glu Glu Leu Lys Asn Val Thr Asn Asn Leu Lys Ser Leu 
        195                 200                 205             


Glu Ala Gln Ala Glu Lys Tyr Ser Gln Lys Glu Asp Lys Tyr Glu Glu 
    210                 215                 220                 


Glu Ile Lys Ile Leu Thr Asp Lys Leu Lys Glu Ala Glu Thr Arg Ala 
225                 230                 235                 240 


Glu Phe Ala Glu Arg Ser Val Ala Lys Leu Glu Lys Thr Ile Asp Asp 
                245                 250                 255     


Leu Glu Asp Glu Leu Tyr Ala Gln Lys Leu Lys Tyr Lys Ala Ile Ser 
            260                 265                 270         


Glu Glu Leu Asp His Ala Leu Asn Asp Met Thr Ser Ile 
        275                 280                 285 

<210>  1064
<211>  658
<212>  DNA
<213>  Homo sapiens

<400>  1064
agggcgtagc aggcggaagt aagggtgaga ggaggctgca acgccgagcg gaggaggcag     60

gaaccggagc gcgagcagta gctgggtggg caccatggct gggatcacca ccatcgaggc    120

ggtgaagcgc aagatccagg ttctgcagca gcaggcagat gatgcagagg agcgagctga    180

gcgcctccag cgagaagttg agggagaaag gcgggcccgg gaacaggctg aggctgaggt    240

ggcctccttg aaccgtagga tccagctggt tgaagaagag ctggaccgtg ctcaggagcg    300

cctggccact gccctgcaaa agctggaaga agctgaaaaa gctgctgatg agagtgagag    360

aggtatgaag gttattgaaa accgggcctt aaaagatgaa gaaaagatgg aactccagga    420

aatccaactc aaagaagcta agcacattgc agaagaggca gataggaagt atgaagaggt    480

ggctcgtaag ttggtgatca ttgaaggaga cttggaacgc acagaggaac gagctgagct    540

ggcagagtct aagtgttctg agctggagga ggagctgaag aatgtcacca acaacctcaa    600

gtctcttgag gctcaggcgg agaagtactc tcaaaaagaa gataaatatg aggaagaa      658


<210>  1065
<211>  187
<212>  PRT
<213>  Homo sapiens

<400>  1065


Met Ala Gly Ile Thr Thr Ile Glu Ala Val Lys Arg Lys Ile Gln Val 
1               5                   10                  15      


Leu Gln Gln Gln Ala Asp Asp Ala Glu Glu Arg Ala Glu Arg Leu Gln 
            20                  25                  30          


Arg Glu Val Glu Gly Glu Arg Arg Ala Arg Glu Gln Ala Glu Ala Glu 
        35                  40                  45              


Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu Glu Glu Leu Asp 
    50                  55                  60                  


Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys Leu Glu Glu Ala 
65                  70                  75                  80  


Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys Val Ile Glu Asn 
                85                  90                  95      


Arg Ala Leu Lys Asp Glu Glu Lys Met Glu Leu Gln Glu Ile Gln Leu 
            100                 105                 110         


Lys Glu Ala Lys His Ile Ala Glu Glu Ala Asp Arg Lys Tyr Glu Glu 
        115                 120                 125             


Val Ala Arg Lys Leu Val Ile Ile Glu Gly Asp Leu Glu Arg Thr Glu 
    130                 135                 140                 


Glu Arg Ala Glu Leu Ala Glu Ser Lys Cys Ser Glu Leu Glu Glu Glu 
145                 150                 155                 160 


Leu Lys Asn Val Thr Asn Asn Leu Lys Ser Leu Glu Ala Gln Ala Glu 
                165                 170                 175     


Lys Tyr Ser Gln Lys Glu Asp Lys Tyr Glu Glu 
            180                 185         

<210>  1066
<211>  581
<212>  DNA
<213>  Homo sapiens

<400>  1066
agataaagac tcaagtctgg ggacctcctg gtcactcagg cagcagcccc ttctttcttg     60

ccccagtctc cagttctcca gtgttcacag gtgagcctac caacagccac tgctcatgat    120

ggaggccatc aagaaaaaga tgcagatgct gaagttagac aaggagaatg ctctggatcg    180

ggcagagcaa gctgaagctg agcagaagca ggcagaagaa agaagtaaac agctggagga    240

tgagctggca gccatgcaga agaagctgaa agggacagag gatgaaggta tgaaggttat    300

tgaaaaccgg gccttaaaag atgaagaaaa gatggaactc caggaaatcc aactcaaaga    360

agctaagcac attgcagaag aggcagatag gaagtatgaa gaggtggctc gtaagttggt    420

gatcattgaa ggagacttgg aacgcacaga ggaacgagct gagctggcag agtctaagtg    480

ttctgagctg gaggaggagc tgaagaatgt caccaacaac ctcaagtctc ttgaggctca    540

ggcggagaag tactctcaaa aagaagataa atatgaggaa g                        581


<210>  1067
<211>  154
<212>  PRT
<213>  Homo sapiens

<400>  1067


Met Met Glu Ala Ile Lys Lys Lys Met Gln Met Leu Lys Leu Asp Lys 
1               5                   10                  15      


Glu Asn Ala Leu Asp Arg Ala Glu Gln Ala Glu Ala Glu Gln Lys Gln 
            20                  25                  30          


Ala Glu Glu Arg Ser Lys Gln Leu Glu Asp Glu Leu Ala Ala Met Gln 
        35                  40                  45              


Lys Lys Leu Lys Gly Thr Glu Asp Glu Gly Met Lys Val Ile Glu Asn 
    50                  55                  60                  


Arg Ala Leu Lys Asp Glu Glu Lys Met Glu Leu Gln Glu Ile Gln Leu 
65                  70                  75                  80  


Lys Glu Ala Lys His Ile Ala Glu Glu Ala Asp Arg Lys Tyr Glu Glu 
                85                  90                  95      


Val Ala Arg Lys Leu Val Ile Ile Glu Gly Asp Leu Glu Arg Thr Glu 
            100                 105                 110         


Glu Arg Ala Glu Leu Ala Glu Ser Lys Cys Ser Glu Leu Glu Glu Glu 
        115                 120                 125             


Leu Lys Asn Val Thr Asn Asn Leu Lys Ser Leu Glu Ala Gln Ala Glu 
    130                 135                 140                 


Lys Tyr Ser Gln Lys Glu Asp Lys Tyr Glu 
145                 150                 

<210>  1068
<211>  579
<212>  DNA
<213>  Homo sapiens

<400>  1068
agggcgtagc aggcggaagt aagggtgaga ggaggctgca acgccgagcg gaggaggcag     60

gaaccggagc gcgagcagta gctgggtggg caccatggct gggatcacca ccatcgaggc    120

ggtgaagcgc aagatccagg ttctgcagca gcaggcagat gatgcagagg agcgagctga    180

gcgcctccag cgagaagttg agggagaaag gcgggcccgg gaacaggctg aggctgaggt    240

ggcctccttg aaccgtagga tccagctggt tgaagaagag ctggaccgtg ctcaggagcg    300

cctggccact gccctgcaaa agctggaaga agctgaaaaa gctgctgatg agagtgagag    360

aggtatgaag gttattgaaa accgggcctt aaaagatgaa gaaaagatgg aactccagga    420

aatccaactc aaagaagcta agcacattgc agaagaggca gataggaagt atgaagaggt    480

ggctcgtaag ttggtgatca ttgaaggaga cttggaacgc acagaggaac gagctgagct    540

ggcagagtct actctcaaaa agaagataaa tatgaggaa                           579


<210>  1069
<211>  160
<212>  PRT
<213>  Homo sapiens

<400>  1069


Met Ala Gly Ile Thr Thr Ile Glu Ala Val Lys Arg Lys Ile Gln Val 
1               5                   10                  15      


Leu Gln Gln Gln Ala Asp Asp Ala Glu Glu Arg Ala Glu Arg Leu Gln 
            20                  25                  30          


Arg Glu Val Glu Gly Glu Arg Arg Ala Arg Glu Gln Ala Glu Ala Glu 
        35                  40                  45              


Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu Glu Glu Leu Asp 
    50                  55                  60                  


Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys Leu Glu Glu Ala 
65                  70                  75                  80  


Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys Val Ile Glu Asn 
                85                  90                  95      


Arg Ala Leu Lys Asp Glu Glu Lys Met Glu Leu Gln Glu Ile Gln Leu 
            100                 105                 110         


Lys Glu Ala Lys His Ile Ala Glu Glu Ala Asp Arg Lys Tyr Glu Glu 
        115                 120                 125             


Val Ala Arg Lys Leu Val Ile Ile Glu Gly Asp Leu Glu Arg Thr Glu 
    130                 135                 140                 


Glu Arg Ala Glu Leu Ala Glu Ser Thr Leu Lys Lys Lys Ile Asn Met 
145                 150                 155                 160 

<210>  1070
<211>  2766
<212>  DNA
<213>  Homo sapiens

<400>  1070
agggcgtagc aggcggaagt aagggtgaga ggaggctgca acgccgagcg gaggaggcag     60

gaaccggagc gcgagcagta gctgggtggg caccatggct gggatcacca ccatcgaggc    120

ggtgaagcgc aagatccagg ttctgcagca gcaggcagat gatgcagagg agcgagctga    180

gcgcctccag cgagaagttg agggagaaag gcgggcccgg gaacaggctg aggctgaggt    240

ggcctccttg aaccgtagga tccagctggt tgaagaagag ctggaccgtg ctcaggagcg    300

cctggccact gccctgcaaa agctggaaga agctgaaaaa gctgctgatg agagtgagag    360

aggtatgaag gttattgaaa accgggcctt aaaagatgaa gaaaagatgg aactccagga    420

aatccaactc aaagaagcta agcacattgc agaagaggca gataggaagt atgaagaggt    480

ggctcgtaag ttggtgatca ttgaaggaga cttggaacgc acagaggaac gagctgagct    540

ggcagagtcg tgagtatcta gctccccaaa tcttgtcatt accaatttat cccttcccct    600

ttggcttggg cactaatatg aataaattag cattccttca accttgttaa acagggccta    660

gggaatggga gtcatctata gtgctttttt aggcccaaga atggttttag gcttccttat    720

tctcctgact agtgacaagt gacaaaagag gctttcttat tttttgttgg tagggtttac    780

aaattgagag caaataagga ctaatacatg gtgaacagtt aattggaaga tcctactggg    840

tccttccacc tggggtggaa gacatcaaag tggctatcct gatttaagat ctagtgtctg    900

gctgggtgtg gtggctcaaa cctgtagtcc cagctactta gtatgccaag gcaggaaggt    960

tgcttgaacc caggagttgg aggccagcct gggcgtcata gggagaccct gtccctaaaa   1020

caaataaatt taaaaaaaaa atctggtgtc tgttttggcc actttgccaa tctgctaggg   1080

aaccttaggg caagggtaga tattaactgc tctcccgtcg gtaccttctg ggccttgatt   1140

aacaaagtca gtgctgaatg catatgtatt tgtgcttccc tcttacattc ccgtctgcca   1200

gacataacat atcatgacca tggtggtgtt ctcttcccat tttttgaatt tttttttttc   1260

gttttgctgc ttgttttctt gctgtgttcc tttttgacct ttctccctcc ccacaacctg   1320

gcttgtgcca tccccgtgac tatcactaac agccgttgcc gagagatgga tgagcagatt   1380

agactgatgg accagaacct gaagtgtctg agtgctgctg aagaaaaggt actaaccatt   1440

aagcccacag caaggttata tatgtggtgt ggttttgttt tgttttgttt ttgttttgca   1500

gctgcctccc ctccacttga ttttgttgag tgctgtctca tctcttcatg gaatgctcca   1560

ttcttttcca cttacttggc atctttcatc tcttctttcc tagttgcttc actgcctctc   1620

cacagggtct ccttcctttg ggtgatttgg gggactgttt gggttgggca tttgttccca   1680

cctccacccc aggtagcagt tatgacttgt tcctggtagt ggatttctct caagtgcttt   1740

attagtattc aaacattttt gagcccagga aggtctagct cctgacacgt tctatggtag   1800

agggaggagg gttgatgctt gctcaggtta cttgggaaca tctcttcccc agtatgcctt   1860

ccaactctct ctacatatag gttcaattca cgtctatgtg tctctctccc tttttttatt   1920

ctcttccttt tcccttttcc tctcctgtgg tatttaaaat attcacagta agtgttctga   1980

gctggaggag gagctgaaga atgtcaccaa caacctcaag tctcttgagg ctcaggcgga   2040

gaaggtaggg gctggtttgt gaaagtgaca ggctttgggg cctgggccca gccctgccct   2100

tgatgaaaga ctggagacac gcattccata tataatccag tgaggcgtgt cctcttccta   2160

cctccttacc atgtattcag gttctgggtt taatgctatt ttctgtgcac tttgattgct   2220

ttaattaaaa taacttcttg gtctcaggtt actggagtca tgtgctcctt aggctgatac   2280

tgctgtgctg aaaagcaata atcaagggcc ctaacaggct ttctagcaga cagatggggg   2340

caacagacag aatcagctct gagacctaat gagcaatcaa gacagatgac ttcactttgc   2400

catcatgtgg gtgtgtttca gtcatgtgac cttggggtgc tactactctt gctcatcaag   2460

caggggaaag gaaaaacacc tccttgggtt gatctgaata atatcaaagc ttagatccat   2520

cttaaaaagt catggagaat tttaacctga ggatctcatg gctctaaaga catagatttc   2580

tgaatttcaa ggacctattg tccagagcca ggccttgctc ttactcttgg accattcagc   2640

acatttagtg caagaggata ttcaatgtaa gttaaatgta gggagggggg tattgcctgt   2700

gtgactaatt tctactctga aatttttaat ctacttatct tacagtactc tcaaaaagaa   2760

gataaa                                                              2766


<210>  1071
<211>  152
<212>  PRT
<213>  Homo sapiens

<400>  1071


Met Ala Gly Ile Thr Thr Ile Glu Ala Val Lys Arg Lys Ile Gln Val 
1               5                   10                  15      


Leu Gln Gln Gln Ala Asp Asp Ala Glu Glu Arg Ala Glu Arg Leu Gln 
            20                  25                  30          


Arg Glu Val Glu Gly Glu Arg Arg Ala Arg Glu Gln Ala Glu Ala Glu 
        35                  40                  45              


Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu Glu Glu Leu Asp 
    50                  55                  60                  


Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys Leu Glu Glu Ala 
65                  70                  75                  80  


Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met Lys Val Ile Glu Asn 
                85                  90                  95      


Arg Ala Leu Lys Asp Glu Glu Lys Met Glu Leu Gln Glu Ile Gln Leu 
            100                 105                 110         


Lys Glu Ala Lys His Ile Ala Glu Glu Ala Asp Arg Lys Tyr Glu Glu 
        115                 120                 125             


Val Ala Arg Lys Leu Val Ile Ile Glu Gly Asp Leu Glu Arg Thr Glu 
    130                 135                 140                 


Glu Arg Ala Glu Leu Ala Glu Ser 
145                 150         

<210>  1072
<211>  2666
<212>  DNA
<213>  Homo sapiens

<400>  1072
ttcagggcgt agcaggcgga agtaagggtg agaggaggct gcaacgccga gcggaggagg     60

caggaaccgg agcgcgagca gtagctgggt gggcaccatg gctgggatca ccaccatcga    120

ggcggtgaag cgcaagatcc aggttctgca gcagcaggca gatgatgcag aggagcgagc    180

tgagcgcctc cagcgagaag ttgagggaga aaggcgggcc cgggaacagg ctgaggctga    240

ggtggcctcc ttgaaccgta ggatccagct ggttgaagaa gagctggacc gtgctcagga    300

gcgcctggcc actgccctgc aaaagctgga agaaaagcta agcacattgc agaagaggca    360

gataggaagt atgaagaggt ggctcgtaag ttggtgatca ttgaaggaga cttggaacgc    420

acagaggaac gagctgagct ggcagagtcg tgagtatcta gctccccaaa tcttgtcatt    480

accaatttat cccttcccct ttggcttggg cactaatatg aataaattag cattccttca    540

accttgttaa acagggccta gggaatggga gtcatctata gtgctttttt aggcccaaga    600

atggttttag gcttccttat tctcctgact agtgacaagt gacaaaagag gctttcttat    660

tttttgttgg tagggtttac aaattgagag caaataagga ctaatacatg gtgaacagtt    720

aattggaaga tcctactggg tccttccacc tggggtggaa gacatcaaag tggctatcct    780

gatttaagat ctagtgtctg gctgggtgtg gtggctcaaa cctgtagtcc cagctactta    840

gtatgccaag gcaggaaggt tgcttgaacc caggagttgg aggccagcct gggcgtcata    900

gggagaccct gtccctaaaa caaataaatt taaaaaaaaa atctggtgtc tgttttggcc    960

actttgccaa tctgctaggg aaccttaggg caagggtaga tattaactgc tctcccgtcg   1020

gtaccttctg ggccttgatt aacaaagtca gtgctgaatg catatgtatt tgtgcttccc   1080

tcttacattc ccgtctgcca gacataacat atcatgacca tggtggtgtt ctcttcccat   1140

tttttgaatt tttttttttc gttttgctgc ttgttttctt gctgtgttcc tttttgacct   1200

ttctccctcc ccacaacctg gcttgtgcca tccccgtgac tatcactaac agccgttgcc   1260

gagagatgga tgagcagatt agactgatgg accagaacct gaagtgtctg agtgctgctg   1320

aagaaaaggt actaaccatt aagcccacag caaggttata tatgtggtgt ggttttgttt   1380

tgttttgttt ttgttttgca gctgcctccc ctccacttga ttttgttgag tgctgtctca   1440

tctcttcatg gaatgctcca ttcttttcca cttacttggc atctttcatc tcttctttcc   1500

tagttgcttc actgcctctc cacagggtct ccttcctttg ggtgatttgg gggactgttt   1560

gggttgggca tttgttccca cctccacccc aggtagcagt tatgacttgt tcctggtagt   1620

ggatttctct caagtgcttt attagtattc aaacattttt gagcccagga aggtctagct   1680

cctgacacgt tctatggtag agggaggagg gttgatgctt gctcaggtta cttgggaaca   1740

tctcttcccc agtatgcctt ccaactctct ctacatatag gttcaattca cgtctatgtg   1800

tctctctccc tttttttatt ctcttccttt tcccttttcc tctcctgtgg tatttaaaat   1860

attcacagta agtgttctga gctggaggag gagctgaaga atgtcaccaa caacctcaag   1920

tctcttgagg ctcaggcgga gaaggtaggg gctggtttgt gaaagtgaca ggctttgggg   1980

cctgggccca gccctgccct tgatgaaaga ctggagacac gcattccata tataatccag   2040

tgaggcgtgt cctcttccta cctccttacc atgtattcag gttctgggtt taatgctatt   2100

ttctgtgcac tttgattgct ttaattaaaa taacttcttg gtctcaggtt actggagtca   2160

tgtgctcctt aggctgatac tgctgtgctg aaaagcaata atcaagggcc ctaacaggct   2220

ttctagcaga cagatggggg caacagacag aatcagctct gagacctaat gagcaatcaa   2280

gacagatgac ttcactttgc catcatgtgg gtgtgtttca gtcatgtgac cttggggtgc   2340

tactactctt gctcatcaag caggggaaag gaaaaacacc tccttgggtt gatctgaata   2400

atatcaaagc ttagatccat cttaaaaagt catggagaat tttaacctga ggatctcatg   2460

gctctaaaga catagatttc tgaatttcaa ggacctattg tccagagcca ggccttgctc   2520

ttactcttgg accattcagc acatttagtg caagaggata ttcaatgtaa gttaaatgta   2580

gggagggggg tattgcctgt gtgactaatt tctactctga aatttttaat ctacttatct   2640

tacagtactc tcaaaaagaa gataaa                                        2666


<210>  1073
<211>  99
<212>  PRT
<213>  Homo sapiens

<400>  1073


Met Ala Gly Ile Thr Thr Ile Glu Ala Val Lys Arg Lys Ile Gln Val 
1               5                   10                  15      


Leu Gln Gln Gln Ala Asp Asp Ala Glu Glu Arg Ala Glu Arg Leu Gln 
            20                  25                  30          


Arg Glu Val Glu Gly Glu Arg Arg Ala Arg Glu Gln Ala Glu Ala Glu 
        35                  40                  45              


Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val Glu Glu Glu Leu Asp 
    50                  55                  60                  


Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln Lys Leu Glu Glu Lys 
65                  70                  75                  80  


Leu Ser Thr Leu Gln Lys Arg Gln Ile Gly Ser Met Lys Arg Trp Leu 
                85                  90                  95      


Val Ser Trp 
            

<210>  1074
<211>  1897
<212>  DNA
<213>  Homo sapiens

<400>  1074
tttcagggcg tagcaggcgg aagtaagggt gagaggaggc tgcaacgccg agcggaggag     60

gcaggaaccg gagcgcgagc agtagctggg tgggcaccat ggctgggatc accaccatcg    120

aggcggtgaa gcgcaagatc caggttctgc agcagcaggc agatgatgca gaggagcgag    180

ctgagcgcct ccagcgagaa gttgagggag aaaggcgggc ccgggaacag gctgaggctg    240

aggtggcctc cttgaaccgt aggatccagc tggttgaaga agagctggac cgtgctcagg    300

agcgcctggc cactgccctg caaaagctgg aagaaaaaag atggaactcc aggaaatcca    360

actcaaagaa gctaagcaca ttgcagaaga ggcagatagg aagtatgaag aggtggctcg    420

taagttggtg atcattgaag gagacttgga acgcacagag gaacgagctg agctggcaga    480

gtcccgttgc cgagagatgg atgagcagat tagactgatg gaccagaacc tgaagtgtct    540

gagtgctgct gaagaaaagg tactaaccat taagcccaca gcaaggttat atatgtggtg    600

tggttttgtt ttgttttgtt tttgttttgc agctgcctcc cctccacttg attttgttga    660

gtgctgtctc atctcttcat ggaatgctcc attcttttcc acttacttgg catctttcat    720

ctcttctttc ctagttgctt cactgcctct ccacagggtc tccttccttt gggtgatttg    780

ggggactgtt tgggttgggc atttgttccc acctccaccc caggtagcag ttatgacttg    840

ttcctggtag tggatttctc tcaagtgctt tattagtatt caaacatttt tgagcccagg    900

aaggtctagc tcctgacacg ttctatggta gagggaggag ggttgatgct tgctcaggtt    960

acttgggaac atctcttccc cagtatgcct tccaactctc tctacatata ggttcaattc   1020

acgtctatgt gtctctctcc ctttttttat tctcttcctt ttcccttttc ctctcctgtg   1080

gtatttaaaa tattcacagt aagtgttctg agctggagga ggagctgaag aatgtcacca   1140

acaacctcaa gtctcttgag gctcaggcgg agaaggtagg ggctggtttg tgaaagtgac   1200

aggctttggg gcctgggccc agccctgccc ttgatgaaag actggagaca cgcattccat   1260

atataatcca gtgaggcgtg tcctcttcct acctccttac catgtattca ggttctgggt   1320

ttaatgctat tttctgtgca ctttgattgc tttaattaaa ataacttctt ggtctcaggt   1380

tactggagtc atgtgctcct taggctgata ctgctgtgct gaaaagcaat aatcaagggc   1440

cctaacaggc tttctagcag acagatgggg gcaacagaca gaatcagctc tgagacctaa   1500

tgagcaatca agacagatga cttcactttg ccatcatgtg ggtgtgtttc agtcatgtga   1560

ccttggggtg ctactactct tgctcatcaa gcaggggaaa ggaaaaacac ctccttgggt   1620

tgatctgaat aatatcaaag cttagatcca tcttaaaaag tcatggagaa ttttaacctg   1680

aggatctcat ggctctaaag acatagattt ctgaatttca aggacctatt gtccagagcc   1740

aggccttgct cttactcttg gaccattcag cacatttagt gcaagaggat attcaatgta   1800

agttaaatgt agggaggggg gtattgcctg tgtgactaat ttctactctg aaatttttaa   1860

tctacttatc ttacagtact ctcaaaaaga agataaa                            1897


<210>  1075
<211>  169
<212>  PRT
<213>  Homo sapiens

<400>  1075


Met Glu Leu Gln Glu Ile Gln Leu Lys Glu Ala Lys His Ile Ala Glu 
1               5                   10                  15      


Glu Ala Asp Arg Lys Tyr Glu Glu Val Ala Arg Lys Leu Val Ile Ile 
            20                  25                  30          


Glu Gly Asp Leu Glu Arg Thr Glu Glu Arg Ala Glu Leu Ala Glu Ser 
        35                  40                  45              


Arg Cys Arg Glu Met Asp Glu Gln Ile Arg Leu Met Asp Gln Asn Leu 
    50                  55                  60                  


Lys Cys Leu Ser Ala Ala Glu Glu Lys Val Leu Thr Ile Lys Pro Thr 
65                  70                  75                  80  


Ala Arg Leu Tyr Met Trp Cys Gly Phe Val Leu Phe Cys Phe Cys Phe 
                85                  90                  95      


Ala Ala Ala Ser Pro Pro Leu Asp Phe Val Glu Cys Cys Leu Ile Ser 
            100                 105                 110         


Ser Trp Asn Ala Pro Phe Phe Ser Thr Tyr Leu Ala Ser Phe Ile Ser 
        115                 120                 125             


Ser Phe Leu Val Ala Ser Leu Pro Leu His Arg Val Ser Phe Leu Trp 
    130                 135                 140                 


Val Ile Trp Gly Thr Val Trp Val Gly His Leu Phe Pro Pro Pro Pro 
145                 150                 155                 160 


Gln Val Ala Val Met Thr Cys Ser Trp 
                165                 

<210>  1076
<211>  2976
<212>  DNA
<213>  Homo sapiens

<400>  1076
gttcccccag gagaacaatg atggggtgga gggagctgga aagaccatat taggaacaaa     60

aggtggagct atgagcacag ataaagactc aagtctgggg acctcctggt cactcaggca    120

gcagcccctt ctttcttgcc ccagtctcca gttctccagt gttcacaggt gagcctacca    180

acagccactg ctcatgatgg aggccatcaa gaaaaagatg cagatgctga agttagacaa    240

ggagaatgct ctggatcggg cagagcaagc tgaagctgag cagaagcagg cagaagaaag    300

aagtaaacag ctggaggatg agctggcagc catgcagaag aagctgaaag ggacagagga    360

tgagctggac aagtattctg aagctttgaa ggatgcccag gagaagctgg aactggcaga    420

gaagaaggct gctgatgctg aggctgaggt ggcctccttg aaccgtagga tccagctggt    480

tgaagaagag ctggaccgtg ctcaggagcg cctggccact gccctgcaaa agctggaaga    540

agctgaaaaa gctgctgatg agagtgagag aggtatgaag gttattgaaa accgggcctt    600

aaaagatgaa gaaaagatgg aactccagga aatccaactc aaagaagcta agcacattgc    660

agaagaggca gataggaagt atgaagaggt ggctcgtaag ttggtgatca ttgaaggaga    720

cttggaacgc acagaggaac gagctgagct ggcagagtcg tgagtatcta gctccccaaa    780

tcttgtcatt accaatttat cccttcccct ttggcttggg cactaatatg aataaattag    840

cattccttca accttgttaa acagggccta gggaatggga gtcatctata gtgctttttt    900

aggcccaaga atggttttag gcttccttat tctcctgact agtgacaagt gacaaaagag    960

gctttcttat tttttgttgg tagggtttac aaattgagag caaataagga ctaatacatg   1020

gtgaacagtt aattggaaga tcctactggg tccttccacc tggggtggaa gacatcaaag   1080

tggctatcct gatttaagat ctagtgtctg gctgggtgtg gtggctcaaa cctgtagtcc   1140

cagctactta gtatgccaag gcaggaaggt tgcttgaacc caggagttgg aggccagcct   1200

gggcgtcata gggagaccct gtccctaaaa caaataaatt taaaaaaaaa atctggtgtc   1260

tgttttggcc actttgccaa tctgctaggg aaccttaggg caagggtaga tattaactgc   1320

tctcccgtcg gtaccttctg ggccttgatt aacaaagtca gtgctgaatg catatgtatt   1380

tgtgcttccc tcttacattc ccgtctgcca gacataacat atcatgacca tggtggtgtt   1440

ctcttcccat tttttgaatt tttttttttc gttttgctgc ttgttttctt gctgtgttcc   1500

tttttgacct ttctccctcc ccacaacctg gcttgtgcca tccccgtgac tatcactaac   1560

agccgttgcc gagagatgga tgagcagatt agactgatgg accagaacct gaagtgtctg   1620

agtgctgctg aagaaaaggt actaaccatt aagcccacag caaggttata tatgtggtgt   1680

ggttttgttt tgttttgttt ttgttttgca gctgcctccc ctccacttga ttttgttgag   1740

tgctgtctca tctcttcatg gaatgctcca ttcttttcca cttacttggc atctttcatc   1800

tcttctttcc tagttgcttc actgcctctc cacagggtct ccttcctttg ggtgatttgg   1860

gggactgttt gggttgggca tttgttccca cctccacccc aggtagcagt tatgacttgt   1920

tcctggtagt ggatttctct caagtgcttt attagtattc aaacattttt gagcccagga   1980

aggtctagct cctgacacgt tctatggtag agggaggagg gttgatgctt gctcaggtta   2040

cttgggaaca tctcttcccc agtatgcctt ccaactctct ctacatatag gttcaattca   2100

cgtctatgtg tctctctccc tttttttatt ctcttccttt tcccttttcc tctcctgtgg   2160

tatttaaaat attcacagta agtgttctga gctggaggag gagctgaaga atgtcaccaa   2220

caacctcaag tctcttgagg ctcaggcgga gaaggtaggg gctggtttgt gaaagtgaca   2280

ggctttgggg cctgggccca gccctgccct tgatgaaaga ctggagacac gcattccata   2340

tataatccag tgaggcgtgt cctcttccta cctccttacc atgtattcag gttctgggtt   2400

taatgctatt ttctgtgcac tttgattgct ttaattaaaa taacttcttg gtctcaggtt   2460

actggagtca tgtgctcctt aggctgatac tgctgtgctg aaaagcaata atcaagggcc   2520

ctaacaggct ttctagcaga cagatggggg caacagacag aatcagctct gagacctaat   2580

gagcaatcaa gacagatgac ttcactttgc catcatgtgg gtgtgtttca gtcatgtgac   2640

cttggggtgc tactactctt gctcatcaag caggggaaag gaaaaacacc tccttgggtt   2700

gatctgaata atatcaaagc ttagatccat cttaaaaagt catggagaat tttaacctga   2760

ggatctcatg gctctaaaga catagatttc tgaatttcaa ggacctattg tccagagcca   2820

ggccttgctc ttactcttgg accattcagc acatttagtg caagaggata ttcaatgtaa   2880

gttaaatgta gggagggggg tattgcctgt gtgactaatt tctactctga aatttttaat   2940

ctacttatct tacagtactc tcaaaaagaa gataaa                             2976


<210>  1077
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  1077


Met Met Glu Ala Ile Lys Lys Lys Met Gln Met Leu Lys Leu Asp Lys 
1               5                   10                  15      


Glu Asn Ala Leu Asp Arg Ala Glu Gln Ala Glu Ala Glu Gln Lys Gln 
            20                  25                  30          


Ala Glu Glu Arg Ser Lys Gln Leu Glu Asp Glu Leu Ala Ala Met Gln 
        35                  40                  45              


Lys Lys Leu Lys Gly Thr Glu Asp Glu Leu Asp Lys Tyr Ser Glu Ala 
    50                  55                  60                  


Leu Lys Asp Ala Gln Glu Lys Leu Glu Leu Ala Glu Lys Lys Ala Ala 
65                  70                  75                  80  


Asp Ala Glu Ala Glu Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val 
                85                  90                  95      


Glu Glu Glu Leu Asp Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln 
            100                 105                 110         


Lys Leu Glu Glu Ala Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met 
        115                 120                 125             


Lys Val Ile Glu Asn Arg Ala Leu Lys Asp Glu Glu Lys Met Glu Leu 
    130                 135                 140                 


Gln Glu Ile Gln Leu Lys Glu Ala Lys His Ile Ala Glu Glu Ala Asp 
145                 150                 155                 160 


Arg Lys Tyr Glu Glu Val Ala Arg Lys Leu Val Ile Ile Glu Gly Asp 
                165                 170                 175     


Leu Glu Arg Thr Glu Glu Arg Ala Glu Leu Ala Glu Ser 
            180                 185                 

<210>  1078
<211>  519
<212>  DNA
<213>  Homo sapiens

<400>  1078
gtcactcagg cagcagcccc ttctttcttg ccccagtctc cagttctcca gtgttcacag     60

gtgagcctac caacagccac tgctcatgat ggaggccatc aagaaaaaga tgcagatgct    120

gaagttagac aaggagaatg ctctggatcg ggcagagcaa gctgaagctg agcagaagca    180

ggcagaagaa agaagtaaac agctggagga tgagctggca gccatgcaga agaagctgaa    240

agggacagag gatgagctgg acaagtattc tgaagctttg aaggatgccc aggagaagct    300

ggaactggca gagaagaagg ctgctgatgc tgaggctgag gtggcctcct tgaaccgtag    360

gatccagctg gttgaagaag agctggaccg tgctcaggag cgcctggcca ctgccctgca    420

aaagctggaa gaagctgaaa aagctgctga tgagagtgag agaggtatga aggttattga    480

aaaccgggcc ttaaaagatg aagaaaagat ggaactcca                           519


<210>  1079
<211>  143
<212>  PRT
<213>  Homo sapiens

<400>  1079


Met Met Glu Ala Ile Lys Lys Lys Met Gln Met Leu Lys Leu Asp Lys 
1               5                   10                  15      


Glu Asn Ala Leu Asp Arg Ala Glu Gln Ala Glu Ala Glu Gln Lys Gln 
            20                  25                  30          


Ala Glu Glu Arg Ser Lys Gln Leu Glu Asp Glu Leu Ala Ala Met Gln 
        35                  40                  45              


Lys Lys Leu Lys Gly Thr Glu Asp Glu Leu Asp Lys Tyr Ser Glu Ala 
    50                  55                  60                  


Leu Lys Asp Ala Gln Glu Lys Leu Glu Leu Ala Glu Lys Lys Ala Ala 
65                  70                  75                  80  


Asp Ala Glu Ala Glu Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val 
                85                  90                  95      


Glu Glu Glu Leu Asp Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln 
            100                 105                 110         


Lys Leu Glu Glu Ala Glu Lys Ala Ala Asp Glu Ser Glu Arg Gly Met 
        115                 120                 125             


Lys Val Ile Glu Asn Arg Ala Leu Lys Asp Glu Glu Lys Met Glu 
    130                 135                 140             

<210>  1080
<211>  454
<212>  DNA
<213>  Homo sapiens

<400>  1080
actcaggcag cagccccttc tttcttgccc cagtctccag ttctccagtg ttcacaggtg     60

agcctaccaa cagccactgc tcatgatgga ggccatcaag aaaaagatgc agatgctgaa    120

gttagacaag gagaatgctc tggatcgggc agagcaagct gaagctgagc agaagcaggc    180

agaagaaaga agtaaacagc tggaggatga gctggcagcc atgcagaaga agctgaaagg    240

gacagaggat gagctggaca agtattctga agctttgaag gatgcccagg agaagctgga    300

actggcagag aagaaggctg ctgatgctga ggctgaggtg gcctccttga accgtaggat    360

ccagctggtt gaagaagagc tggaccgtgc tcaggagcgc ctggccactg ccctgcaaaa    420

gctggaagaa gctgaaaaag ctgctgatga gagt                                454


<210>  1081
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  1081


Met Met Glu Ala Ile Lys Lys Lys Met Gln Met Leu Lys Leu Asp Lys 
1               5                   10                  15      


Glu Asn Ala Leu Asp Arg Ala Glu Gln Ala Glu Ala Glu Gln Lys Gln 
            20                  25                  30          


Ala Glu Glu Arg Ser Lys Gln Leu Glu Asp Glu Leu Ala Ala Met Gln 
        35                  40                  45              


Lys Lys Leu Lys Gly Thr Glu Asp Glu Leu Asp Lys Tyr Ser Glu Ala 
    50                  55                  60                  


Leu Lys Asp Ala Gln Glu Lys Leu Glu Leu Ala Glu Lys Lys Ala Ala 
65                  70                  75                  80  


Asp Ala Glu Ala Glu Val Ala Ser Leu Asn Arg Arg Ile Gln Leu Val 
                85                  90                  95      


Glu Glu Glu Leu Asp Arg Ala Gln Glu Arg Leu Ala Thr Ala Leu Gln 
            100                 105                 110         


Lys Leu Glu Glu Ala Glu Lys Ala Ala Asp Glu 
        115                 120             

<210>  1082
<211>  463
<212>  DNA
<213>  Homo sapiens

<400>  1082
agcaagctga agctgagcag aagcaggcag aagaaagaag taaacagact gcctttgtga     60

ccttgggaaa gtcagtgagc cacagtatgt ctgctgaatt taagtagaaa tggaccatgt    120

tttggaagaa cccttgactt ctagaggaaa agctggagga tgagctggca gccatgcaga    180

agaagctgaa agggacagag gatgagctgg acaagtattc tgaagctttg aaggatgccc    240

aggagaagct ggaactggca gagaagaagg ctgctgatct ttcccaagtc agaaagtacc    300

ctcagagata tgcataagaa caagaaacag gagagggaag gttgtggcca ggagcaagca    360

agaagaaagg tttctttcct caaagctaga gtcagcaaac taccacctgt gggttaaatc    420

ttgcaacagc ctggttttgt aaataaagtt ttatcggaac aca                      463


<210>  1083
<211>  60
<212>  PRT
<213>  Homo sapiens

<400>  1083


Met Pro Arg Arg Ser Trp Asn Trp Gln Arg Arg Arg Leu Leu Ile Phe 
1               5                   10                  15      


Pro Lys Ser Glu Ser Thr Leu Arg Asp Met His Lys Asn Lys Lys Gln 
            20                  25                  30          


Glu Arg Glu Gly Cys Gly Gln Glu Gln Ala Arg Arg Lys Val Ser Phe 
        35                  40                  45              


Leu Lys Ala Arg Val Ser Lys Leu Pro Pro Val Gly 
    50                  55                  60  

<210>  1084
<211>  203
<212>  DNA
<213>  Homo sapiens

<400>  1084
tagattgaaa agttttttag aagaaaagta ccataggaat cttaccaaca acaacagaaa     60

tgtcccagta ttggtggaaa caagtttctc agtgaactga gttaatagga aaaaaggagc    120

atgtaatatt taaaatcata tttgggccac cccgcccagc caggtttctt tttattgttg    180

ttgttgagat ggagtctcgc tct                                            203


<210>  1085
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  1085


Arg Leu Lys Ser Phe Leu Glu Glu Lys Tyr His Arg Asn Leu Thr Asn 
1               5                   10                  15      


Asn Asn Arg Asn Val Pro Val Leu Val Glu Thr Ser Phe Ser Val Asn 
            20                  25                  30          

<210>  1086
<211>  310
<212>  DNA
<213>  Homo sapiens

<400>  1086
cttctttctt gccccagtct ccagttctcc agtgttcaca ggtgagccta ccaacagcca     60

ctgctcatga tggaggccat caagaaaaag atgcagatgc tgaagttaga caaggagaat    120

gctctggatc gggcagagca agctgaagct gagcagaagc aggcagaaga aagaagtaaa    180

cagctggagg atgagctggc agccatgcag aagaagctga aagggacaga ggatgagctg    240

gacaagtatt ctgaagcttt gaaggatgcc caggagaagc tggaactggc agagaagaag    300

gctgctgatg                                                           310


<210>  1087
<211>  80
<212>  PRT
<213>  Homo sapiens

<400>  1087


Met Met Glu Ala Ile Lys Lys Lys Met Gln Met Leu Lys Leu Asp Lys 
1               5                   10                  15      


Glu Asn Ala Leu Asp Arg Ala Glu Gln Ala Glu Ala Glu Gln Lys Gln 
            20                  25                  30          


Ala Glu Glu Arg Ser Lys Gln Leu Glu Asp Glu Leu Ala Ala Met Gln 
        35                  40                  45              


Lys Lys Leu Lys Gly Thr Glu Asp Glu Leu Asp Lys Tyr Ser Glu Ala 
    50                  55                  60                  


Leu Lys Asp Ala Gln Glu Lys Leu Glu Leu Ala Glu Lys Lys Ala Ala 
65                  70                  75                  80  

<210>  1088
<211>  674
<212>  DNA
<213>  Homo sapiens

<400>  1088
agactgtatc aagcaaatct atagacatgt ctgtggaaaa gatgacaaaa gtagaagaga     60

gttttcaaaa ggccatggga cttaagaaga cggtcgacag gtggcgaaat tcacatactc    120

actgtctgtg gcaaatggca ttgggccaga gaagaaaccc gtatgccacc ctaaggatgc    180

aggacaccat ggtacaggaa ttggcactgg ccaaaaagca actactaatg gtccgtcaag    240

ctgccctgca ccagctgttt gaaaaggagc atcagcagta ccagcaggaa ctaaatcaga    300

tgggcaaagc tttttatgta gagagattct gatggcatcc aaaacactgc tcttccattc    360

tcaacatgcc tgctaaccta gccttctaga acctctacca ccttgaacct ccttcccaaa    420

acatacctgg atcttgctat ctgtcaggga cttaagacag cacttccact ctcacttctc    480

cactctctcg ttaatccttt gccgctattt gggaaacaat ctatgaaaca acagtaacaa    540

caagagtgac gccttgtggt catagtggga tttactatgt tgatgtaagg gggcaggggt    600

ggggaggggt ggacaatgag agttgagaat cctgatttgg tataacaaat aaatttactt    660

cctaaaggct caaa                                                      674


<210>  1089
<211>  101
<212>  PRT
<213>  Homo sapiens

<400>  1089


Met Ser Val Glu Lys Met Thr Lys Val Glu Glu Ser Phe Gln Lys Ala 
1               5                   10                  15      


Met Gly Leu Lys Lys Thr Val Asp Arg Trp Arg Asn Ser His Thr His 
            20                  25                  30          


Cys Leu Trp Gln Met Ala Leu Gly Gln Arg Arg Asn Pro Tyr Ala Thr 
        35                  40                  45              


Leu Arg Met Gln Asp Thr Met Val Gln Glu Leu Ala Leu Ala Lys Lys 
    50                  55                  60                  


Gln Leu Leu Met Val Arg Gln Ala Ala Leu His Gln Leu Phe Glu Lys 
65                  70                  75                  80  


Glu His Gln Gln Tyr Gln Gln Glu Leu Asn Gln Met Gly Lys Ala Phe 
                85                  90                  95      


Tyr Val Glu Arg Phe 
            100     

<210>  1090
<211>  985
<212>  DNA
<213>  Homo sapiens

<400>  1090
tggtttctct gctgctagtt gtttttggta tgagtagggt taaagcacga attgggagct     60

ctcagcgaca tcaccagtca gcagccaaag acctaactca gtcccctgag gtctccccaa    120

caaccatcca ggtgacatac ctcccctcca gtcagaagag taaacgtgcc aagcacttcc    180

ttgaattgaa gagctttaag gataactata acacattgga gagtactctg tgacggagct    240

gaaggactct tgccgtagat taagccagtc agttgcaatg tgcaagacag gctgcttgcc    300

gggccgccct cggaacatct ggcccagcag gcccagactg tatccatcca agttcccgtt    360

gtatccagag ttcttagagc ttgtgtctaa agggtaattc cccaaccctt ccttatgagc    420

atttttagaa cattggctaa gactattttc ccccagtagc gcttttttct ggatttgcat    480

tcaggtgtta ttcttaatgt ttctgtcaaa gcttcttaaa aatcttcact tggtttcagc    540

catagttcac cttccctgtt ccaggtttat ttaattccaa aggtgagagt tggagtgaga    600

tgtcttccat atctatacct ttgtgcacag ttgaatggga actgtttggg tttagggcat    660

cttagagttg attgatggaa aaagcagaca ggaactggtg ggaggtcaag tggggaagtt    720

ggtgaatgtg gaataactta cctttgtgct ccacttaaac cagatgtgtt gcagctttcc    780

tgacatgcaa ggatctactt taattccaca ctctcattaa taaattgaat aaaagggaat    840

gttttggcac ctgatataat ctgccaggct atgtgacagt aggaaggaat ggtttcccct    900

aacaagccca atgcactggt ctgactttat aaattattta ataaaatgaa ctattatcaa    960

ataaaacgta tgaatcagtc cttta                                          985


<210>  1091
<211>  67
<212>  PRT
<213>  Homo sapiens

<400>  1091


Met Ser Arg Val Lys Ala Arg Ile Gly Ser Ser Gln Arg His His Gln 
1               5                   10                  15      


Ser Ala Ala Lys Asp Leu Thr Gln Ser Pro Glu Val Ser Pro Thr Thr 
            20                  25                  30          


Ile Gln Val Thr Tyr Leu Pro Ser Ser Gln Lys Ser Lys Arg Ala Lys 
        35                  40                  45              


His Phe Leu Glu Leu Lys Ser Phe Lys Asp Asn Tyr Asn Thr Leu Glu 
    50                  55                  60                  


Ser Thr Leu 
65          

<210>  1092
<211>  1280
<212>  DNA
<213>  Homo sapiens

<400>  1092
aagatcactg ccactgcact ccagcccggg tgacagagcg agactccatc tcaaaaaaaa     60

agactaaaga atgagaagag atatcattgt gctgttttct ccacagagat cccatttcat    120

tctgaaggcc ggcatccccg ttccttaatg ggcaagaatt tccgctccta cctgctggat    180

ctgcgaaaca ctagtacgcc tttcaagggt gtacgcaaag cactcattga tacccttttg    240

gatggctatg aaacagcccg ctatgggaca ggggtctttg gccagaatga gtacctacgc    300

tatcaggagg ccctgagtga gctggccact gcggttaaag cacgaattgg gagctctcag    360

cgacatcacc agtcagcagc caaagaccta actcagtccc ctgaggtctc cccaacaacc    420

atccaggtga catacctccc ctccagtcag aagagtaaac gtgccaagca cttccttgaa    480

ttgaagagct ttaaggataa ctataacaca ttggagagta ctctgtgacg gagctgaagg    540

actcttgccg tagattaagc cagtcagttg caatgtgcaa gacaggctgc ttgccgggcc    600

gccctcggaa catctggccc agcaggccca gactgtatcc atccaagttc ccgttgtatc    660

cagagttctt agagcttgtg tctaaagggt aattccccaa cccttcctta tgagcatttt    720

tagaacattg gctaagacta ttttccccca gtagcgcttt tttctggatt tgcattcagg    780

tgttattctt aatgtttctg tcaaagcttc ttaaaaatct tcacttggtt tcagccatag    840

ttcaccttcc ctgttccagg tttatttaat tccaaaggtg agagttggag tgagatgtct    900

tccatatcta tacctttgtg cacagttgaa tgggaactgt ttgggtttag ggcatcttag    960

agttgattga tggaaaaagc agacaggaac tggtgggagg tcaagtgggg aagttggtga   1020

atgtggaata acttaccttt gtgctccact taaaccagat gtgttgcagc tttcctgaca   1080

tgcaaggatc tactttaatt ccacactctc attaataaat tgaataaaag ggaatgtttt   1140

ggcacctgat ataatctgcc aggctatgtg acagtaggaa ggaatggttt cccctaacaa   1200

gcccaatgca ctggtctgac tttataaatt atttaataaa atgaactatt atcaaataaa   1260

acgtatgaat cagtccttta                                               1280


<210>  1093
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  1093


Met Gly Lys Asn Phe Arg Ser Tyr Leu Leu Asp Leu Arg Asn Thr Ser 
1               5                   10                  15      


Thr Pro Phe Lys Gly Val Arg Lys Ala Leu Ile Asp Thr Leu Leu Asp 
            20                  25                  30          


Gly Tyr Glu Thr Ala Arg Tyr Gly Thr Gly Val Phe Gly Gln Asn Glu 
        35                  40                  45              


Tyr Leu Arg Tyr Gln Glu Ala Leu Ser Glu Leu Ala Thr Ala Val Lys 
    50                  55                  60                  


Ala Arg Ile Gly Ser Ser Gln Arg His His Gln Ser Ala Ala Lys Asp 
65                  70                  75                  80  


Leu Thr Gln Ser Pro Glu Val Ser Pro Thr Thr Ile Gln Val Thr Tyr 
                85                  90                  95      


Leu Pro Ser Ser Gln Lys Ser Lys Arg Ala Lys His Phe Leu Glu Leu 
            100                 105                 110         


Lys Ser Phe Lys Asp Asn Tyr Asn Thr Leu Glu Ser Thr Leu 
        115                 120                 125     

<210>  1094
<211>  1656
<212>  DNA
<213>  Homo sapiens

<400>  1094
gagtcacgtg tcagggggaa gctggaaggc gtcgttctcc tttcccagct ctcctgcctg     60

tccgccatgt tttcaggccg ggtctggctt ggtcttcccc cgtaaggaaa tggccgggga    120

gctccagggg acccaggcgc cgtcgcttcg gcggagcctg ggctgaccag ccaggacagc    180

ggggtaaacc cgaacaattc tgcgcgaggt gtttgtactg ctatttattt ttgtgaagag    240

gcaaatcatg cgctttgcaa tgaaatctcg aaggggacct catgtccctg tgggacacaa    300

tgcccccaag gacttgaaag aggagattga tattcgactc tccagggttc aggatatcaa    360

gtatgagccc cagctccttg cagatgatga tgctagacta ctacaactgg aaacccaggg    420

aaatcaaagt tgctacaact atctgtatag gatgaaagct ctggatgcca ttcgtacctc    480

tgagatccca tttcattctg aaggccggca tccccgttcc ttaatgggca agaatttccg    540

ctcctacctg ctggatctgc gaaacactag tacgcctttc aagggtgtac gcaaagcact    600

cattgatacc cttttggatg gctatgaaac agcccgctat gggacagggg tctttggcca    660

gaatgagtac ctacgctatc aggaggccct gagtgagctg gccactgcgg ttaaagcacg    720

aattgggagc tctcagcgac atcaccagtc agcagccaaa gacctaactc agtcccctga    780

ggtctcccca acaaccatcc aggtgacata cctcccctcc agtcagaaga gtaaacgtgc    840

caagcacttc cttgaattga agagctttaa ggataactat aacacattgg agagtactct    900

gtgacggagc tgaaggactc ttgccgtaga ttaagccagt cagttgcaat gtgcaagaca    960

ggctgcttgc cgggccgccc tcggaacatc tggcccagca ggcccagact gtatccatcc   1020

aagttcccgt tgtatccaga gttcttagag cttgtgtcta aagggtaatt ccccaaccct   1080

tccttatgag catttttaga acattggcta agactatttt cccccagtag cgcttttttc   1140

tggatttgca ttcaggtgtt attcttaatg tttctgtcaa agcttcttaa aaatcttcac   1200

ttggtttcag ccatagttca ccttccctgt tccaggttta tttaattcca aaggtgagag   1260

ttggagtgag atgtcttcca tatctatacc tttgtgcaca gttgaatggg aactgtttgg   1320

gtttagggca tcttagagtt gattgatgga aaaagcagac aggaactggt gggaggtcaa   1380

gtggggaagt tggtgaatgt ggaataactt acctttgtgc tccacttaaa ccagatgtgt   1440

tgcagctttc ctgacatgca aggatctact ttaattccac actctcatta ataaattgaa   1500

taaaagggaa tgttttggca cctgatataa tctgccaggc tatgtgacag taggaaggaa   1560

tggtttcccc taacaagccc aatgcactgg tctgacttta taaattattt aataaaatga   1620

actattatca aataaaacgt atgaatcagt ccttta                             1656


<210>  1095
<211>  218
<212>  PRT
<213>  Homo sapiens

<400>  1095


Met Arg Phe Ala Met Lys Ser Arg Arg Gly Pro His Val Pro Val Gly 
1               5                   10                  15      


His Asn Ala Pro Lys Asp Leu Lys Glu Glu Ile Asp Ile Arg Leu Ser 
            20                  25                  30          


Arg Val Gln Asp Ile Lys Tyr Glu Pro Gln Leu Leu Ala Asp Asp Asp 
        35                  40                  45              


Ala Arg Leu Leu Gln Leu Glu Thr Gln Gly Asn Gln Ser Cys Tyr Asn 
    50                  55                  60                  


Tyr Leu Tyr Arg Met Lys Ala Leu Asp Ala Ile Arg Thr Ser Glu Ile 
65                  70                  75                  80  


Pro Phe His Ser Glu Gly Arg His Pro Arg Ser Leu Met Gly Lys Asn 
                85                  90                  95      


Phe Arg Ser Tyr Leu Leu Asp Leu Arg Asn Thr Ser Thr Pro Phe Lys 
            100                 105                 110         


Gly Val Arg Lys Ala Leu Ile Asp Thr Leu Leu Asp Gly Tyr Glu Thr 
        115                 120                 125             


Ala Arg Tyr Gly Thr Gly Val Phe Gly Gln Asn Glu Tyr Leu Arg Tyr 
    130                 135                 140                 


Gln Glu Ala Leu Ser Glu Leu Ala Thr Ala Val Lys Ala Arg Ile Gly 
145                 150                 155                 160 


Ser Ser Gln Arg His His Gln Ser Ala Ala Lys Asp Leu Thr Gln Ser 
                165                 170                 175     


Pro Glu Val Ser Pro Thr Thr Ile Gln Val Thr Tyr Leu Pro Ser Ser 
            180                 185                 190         


Gln Lys Ser Lys Arg Ala Lys His Phe Leu Glu Leu Lys Ser Phe Lys 
        195                 200                 205             


Asp Asn Tyr Asn Thr Leu Glu Ser Thr Leu 
    210                 215             

<210>  1096
<211>  1566
<212>  DNA
<213>  Homo sapiens

<400>  1096
cattgcctgc ctgagtcacg tgtcaggggg aagctggaag gcgtcgttct cctttcccag     60

ctctcctgcc tgtccgccat gttttcaggc cgggtctggc ttggtcttcc cccgtaagga    120

aatggccggg gagctccagg ggacccaggc gccgtcgctt cggcggagcc tgggctgacc    180

agccaggaca gcggggtaaa cccgaacaat tctgcgcgag gacttgaaag aggagattga    240

tattcgactc tccagggttc aggatatcaa gtatgagccc cagctccttg cagatgatga    300

tgctagacta ctacaactgg aaacccaggg aaatcaaagt tgctacaact atctgtatag    360

gatgaaagct ctggatgcca ttcgtacctc tgagatccca tttcattctg aaggccggca    420

tccccgttcc ttaatgggca agaatttccg ctcctacctg ctggatctgc gaaacactag    480

tacgcctttc aagggtgtac gcaaagcact cattgatacc cttttggatg gctatgaaac    540

agcccgctat gggacagggg tctttggcca gaatgagtac ctacgctatc aggaggccct    600

gagtgagctg gccactgcgg ttaaagcacg aattgggagc tctcagcgac atcaccagtc    660

agcagccaaa gacctaactc agtcccctga ggtctcccca acaaccatcc aggtgacata    720

cctcccctcc agtcagaaga gtaaacgtgc caagcacttc cttgaattga agagctttaa    780

ggataactat aacacattgg agagtactct gtgacggagc tgaaggactc ttgccgtaga    840

ttaagccagt cagttgcaat gtgcaagaca ggctgcttgc cgggccgccc tcggaacatc    900

tggcccagca ggcccagact gtatccatcc aagttcccgt tgtatccaga gttcttagag    960

cttgtgtcta aagggtaatt ccccaaccct tccttatgag catttttaga acattggcta   1020

agactatttt cccccagtag cgcttttttc tggatttgca ttcaggtgtt attcttaatg   1080

tttctgtcaa agcttcttaa aaatcttcac ttggtttcag ccatagttca ccttccctgt   1140

tccaggttta tttaattcca aaggtgagag ttggagtgag atgtcttcca tatctatacc   1200

tttgtgcaca gttgaatggg aactgtttgg gtttagggca tcttagagtt gattgatgga   1260

aaaagcagac aggaactggt gggaggtcaa gtggggaagt tggtgaatgt ggaataactt   1320

acctttgtgc tccacttaaa ccagatgtgt tgcagctttc ctgacatgca aggatctact   1380

ttaattccac actctcatta ataaattgaa taaaagggaa tgttttggca cctgatataa   1440

tctgccaggc tatgtgacag taggaaggaa tggtttcccc taacaagccc aatgcactgg   1500

tctgacttta taaattattt aataaaatga actattatca aataaaacgt atgaatcagt   1560

ccttta                                                              1566


<210>  1097
<211>  150
<212>  PRT
<213>  Homo sapiens

<400>  1097


Met Lys Ala Leu Asp Ala Ile Arg Thr Ser Glu Ile Pro Phe His Ser 
1               5                   10                  15      


Glu Gly Arg His Pro Arg Ser Leu Met Gly Lys Asn Phe Arg Ser Tyr 
            20                  25                  30          


Leu Leu Asp Leu Arg Asn Thr Ser Thr Pro Phe Lys Gly Val Arg Lys 
        35                  40                  45              


Ala Leu Ile Asp Thr Leu Leu Asp Gly Tyr Glu Thr Ala Arg Tyr Gly 
    50                  55                  60                  


Thr Gly Val Phe Gly Gln Asn Glu Tyr Leu Arg Tyr Gln Glu Ala Leu 
65                  70                  75                  80  


Ser Glu Leu Ala Thr Ala Val Lys Ala Arg Ile Gly Ser Ser Gln Arg 
                85                  90                  95      


His His Gln Ser Ala Ala Lys Asp Leu Thr Gln Ser Pro Glu Val Ser 
            100                 105                 110         


Pro Thr Thr Ile Gln Val Thr Tyr Leu Pro Ser Ser Gln Lys Ser Lys 
        115                 120                 125             


Arg Ala Lys His Phe Leu Glu Leu Lys Ser Phe Lys Asp Asn Tyr Asn 
    130                 135                 140                 


Thr Leu Glu Ser Thr Leu 
145                 150 

<210>  1098
<211>  1673
<212>  DNA
<213>  Homo sapiens

<400>  1098
cttactgtcg tagttccgcg tctgagcgct cgacgctcct gggtgccatt gcctgcctga     60

gtcacgtgtc agggggaagc tggaaggcgt cgttctcctt tcccagctct cctgcctgtc    120

cgccatgttt tcaggccggg tctggcttgg tcttcccccg taaggaaatg gccggggagc    180

tccaggggac ccaggcgccg tcgcttcggc ggagcctggg ctgaccagcc aggacagcgg    240

ggtaaacccg aacaattctg cgcgaggtag ggaggccatg gcgtccggca gtaactggct    300

ctccggggtg aatgtcgtgc tggtgatggc ctacgggagc ctggtgtttg tactgctatt    360

tatttttgtg aagaggcaaa tcatgcgctt tgcaatgaaa tctcgaaggg gacctcatgt    420

ccctgtggga cacaatgccc ccaaggttgc tacaactatc tgtataggat gaaagctctg    480

gatgccattc gtacctctga gatcccattt cattctgaag gccggcatcc ccgttcctta    540

atgggcaaga atttccgctc ctacctgctg gatctgcgaa acactagtac gcctttcaag    600

ggtgtacgca aagcactcat tgataccctt ttggatggct atgaaacagc ccgctatggg    660

acaggggtct ttggccagaa tgagtaccta cgctatcagg aggccctgag tgagctggcc    720

actgcggtta aagcacgaat tgggagctct cagcgacatc accagtcagc agccaaagac    780

ctaactcagt cccctgaggt ctccccaaca accatccagg tgacatacct cccctccagt    840

cagaagagta aacgtgccaa gcacttcctt gaattgaaga gctttaagga taactataac    900

acattggaga gtactctgtg acggagctga aggactcttg ccgtagatta agccagtcag    960

ttgcaatgtg caagacaggc tgcttgccgg gccgccctcg gaacatctgg cccagcaggc   1020

ccagactgta tccatccaag ttcccgttgt atccagagtt cttagagctt gtgtctaaag   1080

ggtaattccc caacccttcc ttatgagcat ttttagaaca ttggctaaga ctattttccc   1140

ccagtagcgc ttttttctgg atttgcattc aggtgttatt cttaatgttt ctgtcaaagc   1200

ttcttaaaaa tcttcacttg gtttcagcca tagttcacct tccctgttcc aggtttattt   1260

aattccaaag gtgagagttg gagtgagatg tcttccatat ctataccttt gtgcacagtt   1320

gaatgggaac tgtttgggtt tagggcatct tagagttgat tgatggaaaa agcagacagg   1380

aactggtggg aggtcaagtg gggaagttgg tgaatgtgga ataacttacc tttgtgctcc   1440

acttaaacca gatgtgttgc agctttcctg acatgcaagg atctacttta attccacact   1500

ctcattaata aattgaataa aagggaatgt tttggcacct gatataatct gccaggctat   1560

gtgacagtag gaaggaatgg tttcccctaa caagcccaat gcactggtct gactttataa   1620

attatttaat aaaatgaact attatcaaat aaaacgtatg aatcagtcct tta          1673


<210>  1099
<211>  150
<212>  PRT
<213>  Homo sapiens

<400>  1099


Met Lys Ala Leu Asp Ala Ile Arg Thr Ser Glu Ile Pro Phe His Ser 
1               5                   10                  15      


Glu Gly Arg His Pro Arg Ser Leu Met Gly Lys Asn Phe Arg Ser Tyr 
            20                  25                  30          


Leu Leu Asp Leu Arg Asn Thr Ser Thr Pro Phe Lys Gly Val Arg Lys 
        35                  40                  45              


Ala Leu Ile Asp Thr Leu Leu Asp Gly Tyr Glu Thr Ala Arg Tyr Gly 
    50                  55                  60                  


Thr Gly Val Phe Gly Gln Asn Glu Tyr Leu Arg Tyr Gln Glu Ala Leu 
65                  70                  75                  80  


Ser Glu Leu Ala Thr Ala Val Lys Ala Arg Ile Gly Ser Ser Gln Arg 
                85                  90                  95      


His His Gln Ser Ala Ala Lys Asp Leu Thr Gln Ser Pro Glu Val Ser 
            100                 105                 110         


Pro Thr Thr Ile Gln Val Thr Tyr Leu Pro Ser Ser Gln Lys Ser Lys 
        115                 120                 125             


Arg Ala Lys His Phe Leu Glu Leu Lys Ser Phe Lys Asp Asn Tyr Asn 
    130                 135                 140                 


Thr Leu Glu Ser Thr Leu 
145                 150 

<210>  1100
<211>  1737
<212>  DNA
<213>  Homo sapiens

<400>  1100
cttactgtcg tagttccgcg tctgagcgct cgacgctcct gggtgccatt gcctgcctga     60

gtcacgtgtc agggggaagc tggaaggcgt cgttctcctt tcccagctct cctgcctgtc    120

cgccatgttt tcaggccggg tctggcttgg tcttcccccg taaggaaatg gccggggagc    180

tccaggggac ccaggcgccg tcgcttcggc ggagcctggg ctgaccagcc aggacagcgg    240

ggtaaacccg aacaattctg cgcgaggtag ggaggccatg gcgtccggca gtaactggct    300

ctccggggtg aatgtcgtgc tggtgatggc ctacgggagc ctggtgtttg tactgctatt    360

tatttttgtg aagaggcaaa tcatgcgctt tgcaatgaaa tctcgaaggg gacctcatgt    420

ccctgtggga cacaatgccc ccaaggactt gaaagaggag attgatattc gactctccag    480

ggttcaggat atcaagtatg agccccagct ccttgcagat gatgatgcta gactactaca    540

actggaaacc cagggaaatc aaaagatccc atttcattct gaaggccggc atccccgttc    600

cttaatgggc aagaatttcc gctcctacct gctggatctg cgaaacacta gtacgccttt    660

caagggtgta cgcaaagcac tcattgatac ccttttggat ggctatgaaa cagcccgcta    720

tgggacaggg gtctttggcc agaatgagta cctacgctat caggaggccc tgagtgagct    780

ggccactgcg gttaaagcac gaattgggag ctctcagcga catcaccagt cagcagccaa    840

agacctaact cagtcccctg aggtctcccc aacaaccatc caggtgacat acctcccctc    900

cagtcagaag agtaaacgtg ccaagcactt ccttgaattg aagagcttta aggataacta    960

taacacattg gagagtactc tgtgacggag ctgaaggact cttgccgtag attaagccag   1020

tcagttgcaa tgtgcaagac aggctgcttg ccgggccgcc ctcggaacat ctggcccagc   1080

aggcccagac tgtatccatc caagttcccg ttgtatccag agttcttaga gcttgtgtct   1140

aaagggtaat tccccaaccc ttccttatga gcatttttag aacattggct aagactattt   1200

tcccccagta gcgctttttt ctggatttgc attcaggtgt tattcttaat gtttctgtca   1260

aagcttctta aaaatcttca cttggtttca gccatagttc accttccctg ttccaggttt   1320

atttaattcc aaaggtgaga gttggagtga gatgtcttcc atatctatac ctttgtgcac   1380

agttgaatgg gaactgtttg ggtttagggc atcttagagt tgattgatgg aaaaagcaga   1440

caggaactgg tgggaggtca agtggggaag ttggtgaatg tggaataact tacctttgtg   1500

ctccacttaa accagatgtg ttgcagcttt cctgacatgc aaggatctac tttaattcca   1560

cactctcatt aataaattga ataaaaggga atgttttggc acctgatata atctgccagg   1620

ctatgtgaca gtaggaagga atggtttccc ctaacaagcc caatgcactg gtctgacttt   1680

ataaattatt taataaaatg aactattatc aaataaaacg tatgaatcag tccttta      1737


<210>  1101
<211>  235
<212>  PRT
<213>  Homo sapiens

<400>  1101


Met Ala Ser Gly Ser Asn Trp Leu Ser Gly Val Asn Val Val Leu Val 
1               5                   10                  15      


Met Ala Tyr Gly Ser Leu Val Phe Val Leu Leu Phe Ile Phe Val Lys 
            20                  25                  30          


Arg Gln Ile Met Arg Phe Ala Met Lys Ser Arg Arg Gly Pro His Val 
        35                  40                  45              


Pro Val Gly His Asn Ala Pro Lys Asp Leu Lys Glu Glu Ile Asp Ile 
    50                  55                  60                  


Arg Leu Ser Arg Val Gln Asp Ile Lys Tyr Glu Pro Gln Leu Leu Ala 
65                  70                  75                  80  


Asp Asp Asp Ala Arg Leu Leu Gln Leu Glu Thr Gln Gly Asn Gln Lys 
                85                  90                  95      


Ile Pro Phe His Ser Glu Gly Arg His Pro Arg Ser Leu Met Gly Lys 
            100                 105                 110         


Asn Phe Arg Ser Tyr Leu Leu Asp Leu Arg Asn Thr Ser Thr Pro Phe 
        115                 120                 125             


Lys Gly Val Arg Lys Ala Leu Ile Asp Thr Leu Leu Asp Gly Tyr Glu 
    130                 135                 140                 


Thr Ala Arg Tyr Gly Thr Gly Val Phe Gly Gln Asn Glu Tyr Leu Arg 
145                 150                 155                 160 


Tyr Gln Glu Ala Leu Ser Glu Leu Ala Thr Ala Val Lys Ala Arg Ile 
                165                 170                 175     


Gly Ser Ser Gln Arg His His Gln Ser Ala Ala Lys Asp Leu Thr Gln 
            180                 185                 190         


Ser Pro Glu Val Ser Pro Thr Thr Ile Gln Val Thr Tyr Leu Pro Ser 
        195                 200                 205             


Ser Gln Lys Ser Lys Arg Ala Lys His Phe Leu Glu Leu Lys Ser Phe 
    210                 215                 220                 


Lys Asp Asn Tyr Asn Thr Leu Glu Ser Thr Leu 
225                 230                 235 

<210>  1102
<211>  1678
<212>  DNA
<213>  Homo sapiens

<400>  1102
cttactgtcg tagttccgcg tctgagcgct cgacgctcct gggtgccatt gcctgcctga     60

gtcacgtgtc agggggaagc tggaaggcgt cgttctcctt tcccagctct cctgcctgtc    120

cgccatgttt tcaggccggg tctggcttgg tcttcccccg taaggaaatg gccggggagc    180

tccaggggac ccaggcgccg tcgcttcggc ggagcctggg ctgaccagcc aggacagcgg    240

ggtaaacccg aacaattctg cgcgaggtag ggaggccatg gcgtccggca gtaactggct    300

ctccggggtg aatgtcgtgc tggtgatggc ctacgggagc ctggtgtttg tactgctatt    360

tatttttgtg aagaggcaaa tcatgcgctt tgcaatgaaa tctcgaaggg gacctcatgt    420

ccctgtggga cacaatgccc ccaaggactt gaaagaggag attgatattc gactctccag    480

ggttcaggat atcaagtatg agccccagct ccttgcagat gatgatgcta gactactaca    540

actggaaacc cagggaaatc aaaagatccc atttcattct gaaggccggc atccccgttc    600

cttaatgggc aagaatttcc gctcctacct gctggatctg cgaaacacta gtacgccttt    660

caagggtgta cgcaaagcac tcattgatac ccttttggat ggctatgaaa cagcccgcta    720

tgggacaggg ggttaaagca cgaattggga gctctcagcg acatcaccag tcagcagcca    780

aagacctaac tcagtcccct gaggtctccc caacaaccat ccaggtgaca tacctcccct    840

ccagtcagaa gagtaaacgt gccaagcact tccttgaatt gaagagcttt aaggataact    900

ataacacatt ggagagtact ctgtgacgga gctgaaggac tcttgccgta gattaagcca    960

gtcagttgca atgtgcaaga caggctgctt gccgggccgc cctcggaaca tctggcccag   1020

caggcccaga ctgtatccat ccaagttccc gttgtatcca gagttcttag agcttgtgtc   1080

taaagggtaa ttccccaacc cttccttatg agcattttta gaacattggc taagactatt   1140

ttcccccagt agcgcttttt tctggatttg cattcaggtg ttattcttaa tgtttctgtc   1200

aaagcttctt aaaaatcttc acttggtttc agccatagtt caccttccct gttccaggtt   1260

tatttaattc caaaggtgag agttggagtg agatgtcttc catatctata cctttgtgca   1320

cagttgaatg ggaactgttt gggtttaggg catcttagag ttgattgatg gaaaaagcag   1380

acaggaactg gtgggaggtc aagtggggaa gttggtgaat gtggaataac ttacctttgt   1440

gctccactta aaccagatgt gttgcagctt tcctgacatg caaggatcta ctttaattcc   1500

acactctcat taataaattg aataaaaggg aatgttttgg cacctgatat aatctgccag   1560

gctatgtgac agtaggaagg aatggtttcc cctaacaagc ccaatgcact ggtctgactt   1620

tataaattat ttaataaaat gaactattat caaataaaac gtatgaatca gtccttta     1678


<210>  1103
<211>  152
<212>  PRT
<213>  Homo sapiens

<400>  1103


Met Ala Ser Gly Ser Asn Trp Leu Ser Gly Val Asn Val Val Leu Val 
1               5                   10                  15      


Met Ala Tyr Gly Ser Leu Val Phe Val Leu Leu Phe Ile Phe Val Lys 
            20                  25                  30          


Arg Gln Ile Met Arg Phe Ala Met Lys Ser Arg Arg Gly Pro His Val 
        35                  40                  45              


Pro Val Gly His Asn Ala Pro Lys Asp Leu Lys Glu Glu Ile Asp Ile 
    50                  55                  60                  


Arg Leu Ser Arg Val Gln Asp Ile Lys Tyr Glu Pro Gln Leu Leu Ala 
65                  70                  75                  80  


Asp Asp Asp Ala Arg Leu Leu Gln Leu Glu Thr Gln Gly Asn Gln Lys 
                85                  90                  95      


Ile Pro Phe His Ser Glu Gly Arg His Pro Arg Ser Leu Met Gly Lys 
            100                 105                 110         


Asn Phe Arg Ser Tyr Leu Leu Asp Leu Arg Asn Thr Ser Thr Pro Phe 
        115                 120                 125             


Lys Gly Val Arg Lys Ala Leu Ile Asp Thr Leu Leu Asp Gly Tyr Glu 
    130                 135                 140                 


Thr Ala Arg Tyr Gly Thr Gly Gly 
145                 150         

<210>  1104
<211>  1517
<212>  DNA
<213>  Homo sapiens

<400>  1104
cttactgtcg tagttccgcg tctgagcgct cgacgctcct gggtgccatt gcctgcctga     60

gtcacgtgtc agggggaagc tggaaggcgt cgttctcctt tcccagctct cctgcctgtc    120

cgccatgttt tcaggccggg tctggcttgg tcttcccccg taaggaaatg gccggggagc    180

tccaggggac ccaggcgccg tcgcttcggc ggagcctggg ctgaccagcc aggacagcgg    240

ggtaaacccg aacaattctg cgcgaggtag ggaggccatg gcgtccggca gtaactggct    300

ctccggggtg aatgtcgtgc tggtgatggc ctacgggagc ctgagatccc atttcattct    360

gaaggccggc atccccgttc cttaatgggc aagaatttcc gctcctacct gctggatctg    420

cgaaacacta gtacgccttt caagggtgta cgcaaagcac tcattgatac ccttttggat    480

ggctatgaaa cagcccgcta tgggacaggg gtctttggcc agaatgagta cctacgctat    540

caggaggccc tgagtgagct ggccactgcg gttaaagcac gaattgggag ctctcagcga    600

catcaccagt cagcagccaa agacctaact cagtcccctg aggtctcccc aacaaccatc    660

caggtgacat acctcccctc cagtcagaag agtaaacgtg ccaagcactt ccttgaattg    720

aagagcttta aggataacta taacacattg gagagtactc tgtgacggag ctgaaggact    780

cttgccgtag attaagccag tcagttgcaa tgtgcaagac aggctgcttg ccgggccgcc    840

ctcggaacat ctggcccagc aggcccagac tgtatccatc caagttcccg ttgtatccag    900

agttcttaga gcttgtgtct aaagggtaat tccccaaccc ttccttatga gcatttttag    960

aacattggct aagactattt tcccccagta gcgctttttt ctggatttgc attcaggtgt   1020

tattcttaat gtttctgtca aagcttctta aaaatcttca cttggtttca gccatagttc   1080

accttccctg ttccaggttt atttaattcc aaaggtgaga gttggagtga gatgtcttcc   1140

atatctatac ctttgtgcac agttgaatgg gaactgtttg ggtttagggc atcttagagt   1200

tgattgatgg aaaaagcaga caggaactgg tgggaggtca agtggggaag ttggtgaatg   1260

tggaataact tacctttgtg ctccacttaa accagatgtg ttgcagcttt cctgacatgc   1320

aaggatctac tttaattcca cactctcatt aataaattga ataaaaggga atgttttggc   1380

acctgatata atctgccagg ctatgtgaca gtaggaagga atggtttccc ctaacaagcc   1440

caatgcactg gtctgacttt ataaattatt taataaaatg aactattatc aaataaaacg   1500

tatgaatcag tccttta                                                  1517


<210>  1105
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  1105


Met Gly Lys Asn Phe Arg Ser Tyr Leu Leu Asp Leu Arg Asn Thr Ser 
1               5                   10                  15      


Thr Pro Phe Lys Gly Val Arg Lys Ala Leu Ile Asp Thr Leu Leu Asp 
            20                  25                  30          


Gly Tyr Glu Thr Ala Arg Tyr Gly Thr Gly Val Phe Gly Gln Asn Glu 
        35                  40                  45              


Tyr Leu Arg Tyr Gln Glu Ala Leu Ser Glu Leu Ala Thr Ala Val Lys 
    50                  55                  60                  


Ala Arg Ile Gly Ser Ser Gln Arg His His Gln Ser Ala Ala Lys Asp 
65                  70                  75                  80  


Leu Thr Gln Ser Pro Glu Val Ser Pro Thr Thr Ile Gln Val Thr Tyr 
                85                  90                  95      


Leu Pro Ser Ser Gln Lys Ser Lys Arg Ala Lys His Phe Leu Glu Leu 
            100                 105                 110         


Lys Ser Phe Lys Asp Asn Tyr Asn Thr Leu Glu Ser Thr Leu 
        115                 120                 125     

<210>  1106
<211>  1571
<212>  DNA
<213>  Homo sapiens

<400>  1106
cttactgtcg tagttccgcg tctgagcgct cgacgctcct gggtgccatt gcctgcctga     60

gtcacgtgtc agggggaagc tggaaggcgt cgttctcctt tcccagctct cctgcctgtc    120

cgccatgttt tcaggccggg tctggcttgg tcttcccccg taaggaaatg gccggggagc    180

tccaggggac ccaggcgccg tcgcttcggc ggagcctggg ctgaccagcc aggacagcgg    240

ggtaaacccg aacaattctg cgcgaggtag ggaggccatg gcgtccggca gtaactggct    300

ctccggggtg aatgtcgtgc tggtgatggc ctacgggagc ctggttgcta caactatctg    360

tataggatga aagctctgga tgccattcgt acctctgaga tcccatttca ttctgaaggc    420

cggcatcccc gttccttaat gggcaagaat ttccgctcct acctgctgga tctgcgaaac    480

actagtacgc ctttcaaggg tgtacgcaaa gcactcattg ataccctttt ggatggctat    540

gaaacagccc gctatgggac aggggtcttt ggccagaatg agtacctacg ctatcaggag    600

gccctgagtg agctggccac tgcggttaaa gcacgaattg ggagctctca gcgacatcac    660

cagtcagcag ccaaagacct aactcagtcc cctgaggtct ccccaacaac catccaggtg    720

acatacctcc cctccagtca gaagagtaaa cgtgccaagc acttccttga attgaagagc    780

tttaaggata actataacac attggagagt actctgtgac ggagctgaag gactcttgcc    840

gtagattaag ccagtcagtt gcaatgtgca agacaggctg cttgccgggc cgccctcgga    900

acatctggcc cagcaggccc agactgtatc catccaagtt cccgttgtat ccagagttct    960

tagagcttgt gtctaaaggg taattcccca acccttcctt atgagcattt ttagaacatt   1020

ggctaagact attttccccc agtagcgctt ttttctggat ttgcattcag gtgttattct   1080

taatgtttct gtcaaagctt cttaaaaatc ttcacttggt ttcagccata gttcaccttc   1140

cctgttccag gtttatttaa ttccaaaggt gagagttgga gtgagatgtc ttccatatct   1200

atacctttgt gcacagttga atgggaactg tttgggttta gggcatctta gagttgattg   1260

atggaaaaag cagacaggaa ctggtgggag gtcaagtggg gaagttggtg aatgtggaat   1320

aacttacctt tgtgctccac ttaaaccaga tgtgttgcag ctttcctgac atgcaaggat   1380

ctactttaat tccacactct cattaataaa ttgaataaaa gggaatgttt tggcacctga   1440

tataatctgc caggctatgt gacagtagga aggaatggtt tcccctaaca agcccaatgc   1500

actggtctga ctttataaat tatttaataa aatgaactat tatcaaataa aacgtatgaa   1560

tcagtccttt a                                                        1571


<210>  1107
<211>  150
<212>  PRT
<213>  Homo sapiens

<400>  1107


Met Lys Ala Leu Asp Ala Ile Arg Thr Ser Glu Ile Pro Phe His Ser 
1               5                   10                  15      


Glu Gly Arg His Pro Arg Ser Leu Met Gly Lys Asn Phe Arg Ser Tyr 
            20                  25                  30          


Leu Leu Asp Leu Arg Asn Thr Ser Thr Pro Phe Lys Gly Val Arg Lys 
        35                  40                  45              


Ala Leu Ile Asp Thr Leu Leu Asp Gly Tyr Glu Thr Ala Arg Tyr Gly 
    50                  55                  60                  


Thr Gly Val Phe Gly Gln Asn Glu Tyr Leu Arg Tyr Gln Glu Ala Leu 
65                  70                  75                  80  


Ser Glu Leu Ala Thr Ala Val Lys Ala Arg Ile Gly Ser Ser Gln Arg 
                85                  90                  95      


His His Gln Ser Ala Ala Lys Asp Leu Thr Gln Ser Pro Glu Val Ser 
            100                 105                 110         


Pro Thr Thr Ile Gln Val Thr Tyr Leu Pro Ser Ser Gln Lys Ser Lys 
        115                 120                 125             


Arg Ala Lys His Phe Leu Glu Leu Lys Ser Phe Lys Asp Asn Tyr Asn 
    130                 135                 140                 


Thr Leu Glu Ser Thr Leu 
145                 150 

<210>  1108
<211>  1825
<212>  DNA
<213>  Homo sapiens

<400>  1108
cttactgtcg tagttccgcg tctgagcgct cgacgctcct gggtgccatt gcctgcctga     60

gtcacgtgtc agggggaagc tggaaggcgt cgttctcctt tcccagctct cctgcctgtc    120

cgccatgttt tcaggccggg tctggcttgg tcttcccccg taaggaaatg gccggggagc    180

tccaggggac ccaggcgccg tcgcttcggc ggagcctggg ctgaccagcc aggacagcgg    240

ggtaaacccg aacaattctg cgcgaggtag ggaggccatg gcgtccggca gtaactggct    300

ctccggggtg aatgtcgtgc tggtgatggc ctacgggagc ctggtgtttg tactgctatt    360

tatttttgtg aagaggcaaa tcatgcgctt tgcaatgaaa tctcgaaggg gacctcatgt    420

ccctgtggga cacaatgccc ccaaggactt gaaagaggag attgatattc gactctccag    480

ggttcaggat atcaagtatg agccccagct ccttgcagat gatgatgcta gactactaca    540

actggaaacc cagggaaatc aaagttgcta caactatctg tataggatga aagctctgga    600

tgccattcgt acctctgaga tcccatttca ttctgaaggc cggcatcccc gttccttaat    660

gggcaagaat ttccgctcct acctgctgga tctgcgaaac actagtacgc ctttcaaggg    720

tgtacgcaaa gcactcattg ataccctttt ggatggctat gaaacagccc gctatgggac    780

aggggtcttt ggccagaatg agtacctacg ctatcaggag gccctgagtg agctggccac    840

tgcgtgagtt tggaggggaa cgtgtcagag ggagctgggt taaagcacga attgggagct    900

ctcagcgaca tcaccagtca gcagccaaag acctaactca gtcccctgag gtctccccaa    960

caaccatcca ggtgacatac ctcccctcca gtcagaagag taaacgtgcc aagcacttcc   1020

ttgaattgaa gagctttaag gataactata acacattgga gagtactctg tgacggagct   1080

gaaggactct tgccgtagat taagccagtc agttgcaatg tgcaagacag gctgcttgcc   1140

gggccgccct cggaacatct ggcccagcag gcccagactg tatccatcca agttcccgtt   1200

gtatccagag ttcttagagc ttgtgtctaa agggtaattc cccaaccctt ccttatgagc   1260

atttttagaa cattggctaa gactattttc ccccagtagc gcttttttct ggatttgcat   1320

tcaggtgtta ttcttaatgt ttctgtcaaa gcttcttaaa aatcttcact tggtttcagc   1380

catagttcac cttccctgtt ccaggtttat ttaattccaa aggtgagagt tggagtgaga   1440

tgtcttccat atctatacct ttgtgcacag ttgaatggga actgtttggg tttagggcat   1500

cttagagttg attgatggaa aaagcagaca ggaactggtg ggaggtcaag tggggaagtt   1560

ggtgaatgtg gaataactta cctttgtgct ccacttaaac cagatgtgtt gcagctttcc   1620

tgacatgcaa ggatctactt taattccaca ctctcattaa taaattgaat aaaagggaat   1680

gttttggcac ctgatataat ctgccaggct atgtgacagt aggaaggaat ggtttcccct   1740

aacaagccca atgcactggt ctgactttat aaattattta ataaaatgaa ctattatcaa   1800

ataaaacgta tgaatcagtc cttta                                         1825


<210>  1109
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  1109


Met Ala Ser Gly Ser Asn Trp Leu Ser Gly Val Asn Val Val Leu Val 
1               5                   10                  15      


Met Ala Tyr Gly Ser Leu Val Phe Val Leu Leu Phe Ile Phe Val Lys 
            20                  25                  30          


Arg Gln Ile Met Arg Phe Ala Met Lys Ser Arg Arg Gly Pro His Val 
        35                  40                  45              


Pro Val Gly His Asn Ala Pro Lys Asp Leu Lys Glu Glu Ile Asp Ile 
    50                  55                  60                  


Arg Leu Ser Arg Val Gln Asp Ile Lys Tyr Glu Pro Gln Leu Leu Ala 
65                  70                  75                  80  


Asp Asp Asp Ala Arg Leu Leu Gln Leu Glu Thr Gln Gly Asn Gln Ser 
                85                  90                  95      


Cys Tyr Asn Tyr Leu Tyr Arg Met Lys Ala Leu Asp Ala Ile Arg Thr 
            100                 105                 110         


Ser Glu Ile Pro Phe His Ser Glu Gly Arg His Pro Arg Ser Leu Met 
        115                 120                 125             


Gly Lys Asn Phe Arg Ser Tyr Leu Leu Asp Leu Arg Asn Thr Ser Thr 
    130                 135                 140                 


Pro Phe Lys Gly Val Arg Lys Ala Leu Ile Asp Thr Leu Leu Asp Gly 
145                 150                 155                 160 


Tyr Glu Thr Ala Arg Tyr Gly Thr Gly Val Phe Gly Gln Asn Glu Tyr 
                165                 170                 175     


Leu Arg Tyr Gln Glu Ala Leu Ser Glu Leu Ala Thr Ala 
            180                 185                 

<210>  1110
<211>  1520
<212>  DNA
<213>  Homo sapiens

<400>  1110
cttactgtcg tagttccgcg tctgagcgct cgacgctcct gggtgccatt gcctgcctga     60

gtcacgtgtc agggggaagc tggaaggcgt cgttctcctt tcccagctct cctgcctgtc    120

cgccatgttt tcaggccggg tctggcttgg tcttcccccg taaggaaatg gccggggagc    180

tccaggggac ccaggcgccg tcgcttcggc ggagcctggg ctgaccagcc aggacagcgg    240

ggtaaacccg aacaattctg cgcgaggtag ggaggccatg gcgtccggca gtaactggct    300

ctccggggtg aatgtcgtgc tggtgatggc ctacgggagc ctggtgtttg tactgctatt    360

tatttttgcc ggcatccccg ttccttaatg ggcaagaatt tccgctccta cctgctggat    420

ctgcgaaaca ctagtacgcc tttcaagggt gtacgcaaag cactcattga tacccttttg    480

gatggctatg aaacagcccg ctatgggaca ggggtctttg gccagaatga gtacctacgc    540

tatcaggagg ccctgagtga gctggccact gcggttaaag cacgaattgg gagctctcag    600

cgacatcacc agtcagcagc caaagaccta actcagtccc ctgaggtctc cccaacaacc    660

atccaggtga catacctccc ctccagtcag aagagtaaac gtgccaagca cttccttgaa    720

ttgaagagct ttaaggataa ctataacaca ttggagagta ctctgtgacg gagctgaagg    780

actcttgccg tagattaagc cagtcagttg caatgtgcaa gacaggctgc ttgccgggcc    840

gccctcggaa catctggccc agcaggccca gactgtatcc atccaagttc ccgttgtatc    900

cagagttctt agagcttgtg tctaaagggt aattccccaa cccttcctta tgagcatttt    960

tagaacattg gctaagacta ttttccccca gtagcgcttt tttctggatt tgcattcagg   1020

tgttattctt aatgtttctg tcaaagcttc ttaaaaatct tcacttggtt tcagccatag   1080

ttcaccttcc ctgttccagg tttatttaat tccaaaggtg agagttggag tgagatgtct   1140

tccatatcta tacctttgtg cacagttgaa tgggaactgt ttgggtttag ggcatcttag   1200

agttgattga tggaaaaagc agacaggaac tggtgggagg tcaagtgggg aagttggtga   1260

atgtggaata acttaccttt gtgctccact taaaccagat gtgttgcagc tttcctgaca   1320

tgcaaggatc tactttaatt ccacactctc attaataaat tgaataaaag ggaatgtttt   1380

ggcacctgat ataatctgcc aggctatgtg acagtaggaa ggaatggttt cccctaacaa   1440

gcccaatgca ctggtctgac tttataaatt atttaataaa atgaactatt atcaaataaa   1500

acgtatgaat cagtccttta                                               1520


<210>  1111
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  1111


Met Gly Lys Asn Phe Arg Ser Tyr Leu Leu Asp Leu Arg Asn Thr Ser 
1               5                   10                  15      


Thr Pro Phe Lys Gly Val Arg Lys Ala Leu Ile Asp Thr Leu Leu Asp 
            20                  25                  30          


Gly Tyr Glu Thr Ala Arg Tyr Gly Thr Gly Val Phe Gly Gln Asn Glu 
        35                  40                  45              


Tyr Leu Arg Tyr Gln Glu Ala Leu Ser Glu Leu Ala Thr Ala Val Lys 
    50                  55                  60                  


Ala Arg Ile Gly Ser Ser Gln Arg His His Gln Ser Ala Ala Lys Asp 
65                  70                  75                  80  


Leu Thr Gln Ser Pro Glu Val Ser Pro Thr Thr Ile Gln Val Thr Tyr 
                85                  90                  95      


Leu Pro Ser Ser Gln Lys Ser Lys Arg Ala Lys His Phe Leu Glu Leu 
            100                 105                 110         


Lys Ser Phe Lys Asp Asn Tyr Asn Thr Leu Glu Ser Thr Leu 
        115                 120                 125     

<210>  1112
<211>  1645
<212>  DNA
<213>  Homo sapiens

<400>  1112
gccgcttcct cttactgtcg tagttccgcg tctgagcgct cgacgctcct gggtgccatt     60

gcctgcctga gtcacgtgtc agggggaagc tggaaggcgt cgttctcctt tcccagctct    120

cctgcctgtc cgccatgttt tcaggccggg tctggcttgg tcttcccccg taaggaaatg    180

gccggggagc tccaggggac ccaggcgccg tcgcttcggc ggagcctggg ctgaccagcc    240

aggacagcgg ggtaaacccg aacaattctg cgcgaggtag ggaggccatg gcgtccggca    300

gtaactggct ctccggggtg aatgtcgtgc tggtgatggc ctacgggagc ctggacttga    360

aagaggagat tgatattcga ctctccaggg ttcaggatat caagtatgag ccccagctcc    420

ttgcagatga tgatgctaga ctactacaac tggaaaccca gggaaatcaa aagatcccat    480

ttcattctga aggccggcat ccccgttcct taatgggcaa gaatttccgc tcctacctgc    540

tggatctgcg aaacactagt acgcctttca agggtgtacg caaagcactc attgataccc    600

ttttggatgg ctatgaaaca gcccgctatg ggacaggggt ctttggccag aatgagtacc    660

tacgctatca ggaggccctg agtgagctgg ccactgcggt taaagcacga attgggagct    720

ctcagcgaca tcaccagtca gcagccaaag acctaactca gtcccctgag gtctccccaa    780

caaccatcca ggtgacatac ctcccctcca gtcagaagag taaacgtgcc aagcacttcc    840

ttgaattgaa gagctttaag gataactata acacattgga gagtactctg tgacggagct    900

gaaggactct tgccgtagat taagccagtc agttgcaatg tgcaagacag gctgcttgcc    960

gggccgccct cggaacatct ggcccagcag gcccagactg tatccatcca agttcccgtt   1020

gtatccagag ttcttagagc ttgtgtctaa agggtaattc cccaaccctt ccttatgagc   1080

atttttagaa cattggctaa gactattttc ccccagtagc gcttttttct ggatttgcat   1140

tcaggtgtta ttcttaatgt ttctgtcaaa gcttcttaaa aatcttcact tggtttcagc   1200

catagttcac cttccctgtt ccaggtttat ttaattccaa aggtgagagt tggagtgaga   1260

tgtcttccat atctatacct ttgtgcacag ttgaatggga actgtttggg tttagggcat   1320

cttagagttg attgatggaa aaagcagaca ggaactggtg ggaggtcaag tggggaagtt   1380

ggtgaatgtg gaataactta cctttgtgct ccacttaaac cagatgtgtt gcagctttcc   1440

tgacatgcaa ggatctactt taattccaca ctctcattaa taaattgaat aaaagggaat   1500

gttttggcac ctgatataat ctgccaggct atgtgacagt aggaaggaat ggtttcccct   1560

aacaagccca atgcactggt ctgactttat aaattattta ataaaatgaa ctattatcaa   1620

ataaaacgta tgaatcagtc cttta                                         1645


<210>  1113
<211>  201
<212>  PRT
<213>  Homo sapiens

<400>  1113


Met Ala Ser Gly Ser Asn Trp Leu Ser Gly Val Asn Val Val Leu Val 
1               5                   10                  15      


Met Ala Tyr Gly Ser Leu Asp Leu Lys Glu Glu Ile Asp Ile Arg Leu 
            20                  25                  30          


Ser Arg Val Gln Asp Ile Lys Tyr Glu Pro Gln Leu Leu Ala Asp Asp 
        35                  40                  45              


Asp Ala Arg Leu Leu Gln Leu Glu Thr Gln Gly Asn Gln Lys Ile Pro 
    50                  55                  60                  


Phe His Ser Glu Gly Arg His Pro Arg Ser Leu Met Gly Lys Asn Phe 
65                  70                  75                  80  


Arg Ser Tyr Leu Leu Asp Leu Arg Asn Thr Ser Thr Pro Phe Lys Gly 
                85                  90                  95      


Val Arg Lys Ala Leu Ile Asp Thr Leu Leu Asp Gly Tyr Glu Thr Ala 
            100                 105                 110         


Arg Tyr Gly Thr Gly Val Phe Gly Gln Asn Glu Tyr Leu Arg Tyr Gln 
        115                 120                 125             


Glu Ala Leu Ser Glu Leu Ala Thr Ala Val Lys Ala Arg Ile Gly Ser 
    130                 135                 140                 


Ser Gln Arg His His Gln Ser Ala Ala Lys Asp Leu Thr Gln Ser Pro 
145                 150                 155                 160 


Glu Val Ser Pro Thr Thr Ile Gln Val Thr Tyr Leu Pro Ser Ser Gln 
                165                 170                 175     


Lys Ser Lys Arg Ala Lys His Phe Leu Glu Leu Lys Ser Phe Lys Asp 
            180                 185                 190         


Asn Tyr Asn Thr Leu Glu Ser Thr Leu 
        195                 200     

<210>  1114
<211>  1699
<212>  DNA
<213>  Homo sapiens

<400>  1114
gccgcttcct cttactgtcg tagttccgcg tctgagcgct cgacgctcct gggtgccatt     60

gcctgcctga gtcacgtgtc agggggaagc tggaaggcgt cgttctcctt tcccagctct    120

cctgcctgtc cgccatgttt tcaggccggg tctggcttgg tcttcccccg taaggaaatg    180

gccggggagc tccaggggac ccaggcgccg tcgcttcggc ggagcctggg ctgaccagcc    240

aggacagcgg ggtaaacccg aacaattctg cgcgaggtag ggaggccatg gcgtccggca    300

gtaactggct ctccggggtg aatgtcgtgc tggtgatggc ctacgggagc ctggacttga    360

aagaggagat tgatattcga ctctccaggg ttcaggatat caagtatgag ccccagctcc    420

ttgcagatga tgatgctaga ctactacaac tggaaaccca gggaaatcaa agttgctaca    480

actatctgta taggatgaaa gctctggatg ccattcgtac ctctgagatc ccatttcatt    540

ctgaaggccg gcatccccgt tccttaatgg gcaagaattt ccgctcctac ctgctggatc    600

tgcgaaacac tagtacgcct ttcaagggtg tacgcaaagc actcattgat acccttttgg    660

atggctatga aacagcccgc tatgggacag gggtctttgg ccagaatgag tacctacgct    720

atcaggaggc cctgagtgag ctggccactg cggttaaagc acgaattggg agctctcagc    780

gacatcacca gtcagcagcc aaagacctaa ctcagtcccc tgaggtctcc ccaacaacca    840

tccaggtgac atacctcccc tccagtcaga agagtaaacg tgccaagcac ttccttgaat    900

tgaagagctt taaggataac tataacacat tggagagtac tctgtgacgg agctgaagga    960

ctcttgccgt agattaagcc agtcagttgc aatgtgcaag acaggctgct tgccgggccg   1020

ccctcggaac atctggccca gcaggcccag actgtatcca tccaagttcc cgttgtatcc   1080

agagttctta gagcttgtgt ctaaagggta attccccaac ccttccttat gagcattttt   1140

agaacattgg ctaagactat tttcccccag tagcgctttt ttctggattt gcattcaggt   1200

gttattctta atgtttctgt caaagcttct taaaaatctt cacttggttt cagccatagt   1260

tcaccttccc tgttccaggt ttatttaatt ccaaaggtga gagttggagt gagatgtctt   1320

ccatatctat acctttgtgc acagttgaat gggaactgtt tgggtttagg gcatcttaga   1380

gttgattgat ggaaaaagca gacaggaact ggtgggaggt caagtgggga agttggtgaa   1440

tgtggaataa cttacctttg tgctccactt aaaccagatg tgttgcagct ttcctgacat   1500

gcaaggatct actttaattc cacactctca ttaataaatt gaataaaagg gaatgttttg   1560

gcacctgata taatctgcca ggctatgtga cagtaggaag gaatggtttc ccctaacaag   1620

cccaatgcac tggtctgact ttataaatta tttaataaaa tgaactatta tcaaataaaa   1680

cgtatgaatc agtccttta                                                1699


<210>  1115
<211>  219
<212>  PRT
<213>  Homo sapiens

<400>  1115


Met Ala Ser Gly Ser Asn Trp Leu Ser Gly Val Asn Val Val Leu Val 
1               5                   10                  15      


Met Ala Tyr Gly Ser Leu Asp Leu Lys Glu Glu Ile Asp Ile Arg Leu 
            20                  25                  30          


Ser Arg Val Gln Asp Ile Lys Tyr Glu Pro Gln Leu Leu Ala Asp Asp 
        35                  40                  45              


Asp Ala Arg Leu Leu Gln Leu Glu Thr Gln Gly Asn Gln Ser Cys Tyr 
    50                  55                  60                  


Asn Tyr Leu Tyr Arg Met Lys Ala Leu Asp Ala Ile Arg Thr Ser Glu 
65                  70                  75                  80  


Ile Pro Phe His Ser Glu Gly Arg His Pro Arg Ser Leu Met Gly Lys 
                85                  90                  95      


Asn Phe Arg Ser Tyr Leu Leu Asp Leu Arg Asn Thr Ser Thr Pro Phe 
            100                 105                 110         


Lys Gly Val Arg Lys Ala Leu Ile Asp Thr Leu Leu Asp Gly Tyr Glu 
        115                 120                 125             


Thr Ala Arg Tyr Gly Thr Gly Val Phe Gly Gln Asn Glu Tyr Leu Arg 
    130                 135                 140                 


Tyr Gln Glu Ala Leu Ser Glu Leu Ala Thr Ala Val Lys Ala Arg Ile 
145                 150                 155                 160 


Gly Ser Ser Gln Arg His His Gln Ser Ala Ala Lys Asp Leu Thr Gln 
                165                 170                 175     


Ser Pro Glu Val Ser Pro Thr Thr Ile Gln Val Thr Tyr Leu Pro Ser 
            180                 185                 190         


Ser Gln Lys Ser Lys Arg Ala Lys His Phe Leu Glu Leu Lys Ser Phe 
        195                 200                 205             


Lys Asp Asn Tyr Asn Thr Leu Glu Ser Thr Leu 
    210                 215                 

<210>  1116
<211>  1826
<212>  DNA
<213>  Homo sapiens

<400>  1116
tccaccacgt gacgcacgga tggccgccgc ttcctcttac tgtcgtagtt ccgcgtctga     60

gcgctcgacg ctcctgggtg ccattgcctg cctgagtcac gtgtcagggg gaagctggaa    120

ggcgtcgttc tcctttccca gctctcctgc ctgtccgcca tgttttcagg ccgggtctgg    180

cttggtcttc ccccgtaagg aaatggccgg ggagctccag gggacccagg cgccgtcgct    240

tcggcggagc ctgggctgac cagccaggac agcggggtaa acccgaacaa ttctgcgcga    300

ggtagggagg ccatggcgtc cggcagtaac tggctctccg gggtgaatgt cgtgctggtg    360

atggcctacg ggagcctggt gtttgtactg ctatttattt ttgtgaagag gcaaatcatg    420

cgctttgcaa tgaaatctcg aaggggacct catgtccctg tgggacacaa tgcccccaag    480

gacttgaaag aggagattga tattcgactc tccagggttc aggatatcaa gtatgagccc    540

cagctccttg cagatgatga tgctagacta ctacaactgg aaacccaggg aaatcaaagt    600

tgctacaact atctgtatag gatgaaagct ctggatgcca ttcgtacctc tgagatccca    660

tttcattctg aaggccggca tccccgttcc ttaatgggca agaatttccg ctcctacctg    720

ctggatctgc gaaacactag tacgcctttc aagggtgtac gcaaagcact cattgatacc    780

cttttggatg gctatgaaac agcccgctat gggacagggg tctttggcca gaatgagtac    840

ctacgctatc aggaggccct gagtgagctg gccactgcgg ttaaagcacg aattgggagc    900

tctcagcgac atcaccagtc agcagccaaa gacctaactc agtcccctga ggtctcccca    960

acaaccatcc aggtgacata cctcccctcc agtcagaaga gtaaacgtgc caagcacttc   1020

cttgaattga agagctttaa ggataactat aacacattgg agagtactct gtgacggagc   1080

tgaaggactc ttgccgtaga ttaagccagt cagttgcaat gtgcaagaca ggctgcttgc   1140

cgggccgccc tcggaacatc tggcccagca ggcccagact gtatccatcc aagttcccgt   1200

tgtatccaga gttcttagag cttgtgtcta aagggtaatt ccccaaccct tccttatgag   1260

catttttaga acattggcta agactatttt cccccagtag cgcttttttc tggatttgca   1320

ttcaggtgtt attcttaatg tttctgtcaa agcttcttaa aaatcttcac ttggtttcag   1380

ccatagttca ccttccctgt tccaggttta tttaattcca aaggtgagag ttggagtgag   1440

atgtcttcca tatctatacc tttgtgcaca gttgaatggg aactgtttgg gtttagggca   1500

tcttagagtt gattgatgga aaaagcagac aggaactggt gggaggtcaa gtggggaagt   1560

tggtgaatgt ggaataactt acctttgtgc tccacttaaa ccagatgtgt tgcagctttc   1620

ctgacatgca aggatctact ttaattccac actctcatta ataaattgaa taaaagggaa   1680

tgttttggca cctgatataa tctgccaggc tatgtgacag taggaaggaa tggtttcccc   1740

taacaagccc aatgcactgg tctgacttta taaattattt aataaaatga actattatca   1800

aataaaacgt atgaatcagt ccttta                                        1826


<210>  1117
<211>  253
<212>  PRT
<213>  Homo sapiens

<400>  1117


Met Ala Ser Gly Ser Asn Trp Leu Ser Gly Val Asn Val Val Leu Val 
1               5                   10                  15      


Met Ala Tyr Gly Ser Leu Val Phe Val Leu Leu Phe Ile Phe Val Lys 
            20                  25                  30          


Arg Gln Ile Met Arg Phe Ala Met Lys Ser Arg Arg Gly Pro His Val 
        35                  40                  45              


Pro Val Gly His Asn Ala Pro Lys Asp Leu Lys Glu Glu Ile Asp Ile 
    50                  55                  60                  


Arg Leu Ser Arg Val Gln Asp Ile Lys Tyr Glu Pro Gln Leu Leu Ala 
65                  70                  75                  80  


Asp Asp Asp Ala Arg Leu Leu Gln Leu Glu Thr Gln Gly Asn Gln Ser 
                85                  90                  95      


Cys Tyr Asn Tyr Leu Tyr Arg Met Lys Ala Leu Asp Ala Ile Arg Thr 
            100                 105                 110         


Ser Glu Ile Pro Phe His Ser Glu Gly Arg His Pro Arg Ser Leu Met 
        115                 120                 125             


Gly Lys Asn Phe Arg Ser Tyr Leu Leu Asp Leu Arg Asn Thr Ser Thr 
    130                 135                 140                 


Pro Phe Lys Gly Val Arg Lys Ala Leu Ile Asp Thr Leu Leu Asp Gly 
145                 150                 155                 160 


Tyr Glu Thr Ala Arg Tyr Gly Thr Gly Val Phe Gly Gln Asn Glu Tyr 
                165                 170                 175     


Leu Arg Tyr Gln Glu Ala Leu Ser Glu Leu Ala Thr Ala Val Lys Ala 
            180                 185                 190         


Arg Ile Gly Ser Ser Gln Arg His His Gln Ser Ala Ala Lys Asp Leu 
        195                 200                 205             


Thr Gln Ser Pro Glu Val Ser Pro Thr Thr Ile Gln Val Thr Tyr Leu 
    210                 215                 220                 


Pro Ser Ser Gln Lys Ser Lys Arg Ala Lys His Phe Leu Glu Leu Lys 
225                 230                 235                 240 


Ser Phe Lys Asp Asn Tyr Asn Thr Leu Glu Ser Thr Leu 
                245                 250             

<210>  1118
<211>  1547
<212>  DNA
<213>  Homo sapiens

<400>  1118
tgcctccacc acgtgacgca cggatggccg ccgcttcctc ttactgtcgt agttccgcgt     60

ctgagcgctc gacgctcctg gaccagccag gacagcgggg taaacccgaa caattctgcg    120

cgaggtaggg aggccatggc gtccggcagt aactggctct ccggggtgaa tgtcgtgctg    180

gtgatggcct acgggagcct ggacttgaaa gaggagattg atattcgact ctccagggtt    240

caggatatca agtatgagcc ccagctcctt gcagatgatg atgctagact actacaactg    300

gaaacccagg gaaatcaaag ttgctacaac tatctgtata ggatgaaagc tctggatgcc    360

attcgtacct ctgagatccc atttcattct gaaggccggc atccccgttc cttaatgggc    420

aagaatttcc gctcctacct gctggatctg cgaaacacta gtacgccttt caagggtgta    480

cgcaaagcac tcattgatac ccttttggat ggctatgaaa cagcccgcta tgggacaggg    540

gtctttggcc agaatgagta cctacgctat caggaggccc tgagtgagct ggccactgcg    600

gttaaagcac gaattgggag ctctcagcga catcaccagt cagcagccaa agacctaact    660

cagtcccctg aggtctcccc aacaaccatc caggtgacat acctcccctc cagtcagaag    720

agtaaacgtg ccaagcactt ccttgaattg aagagcttta aggataacta taacacattg    780

gagagtactc tgtgacggag ctgaaggact cttgccgtag attaagccag tcagttgcaa    840

tgtgcaagac aggctgcttg ccgggccgcc ctcggaacat ctggcccagc aggcccagac    900

tgtatccatc caagttcccg ttgtatccag agttcttaga gcttgtgtct aaagggtaat    960

tccccaaccc ttccttatga gcatttttag aacattggct aagactattt tcccccagta   1020

gcgctttttt ctggatttgc attcaggtgt tattcttaat gtttctgtca aagcttctta   1080

aaaatcttca cttggtttca gccatagttc accttccctg ttccaggttt atttaattcc   1140

aaaggtgaga gttggagtga gatgtcttcc atatctatac ctttgtgcac agttgaatgg   1200

gaactgtttg ggtttagggc atcttagagt tgattgatgg aaaaagcaga caggaactgg   1260

tgggaggtca agtggggaag ttggtgaatg tggaataact tacctttgtg ctccacttaa   1320

accagatgtg ttgcagcttt cctgacatgc aaggatctac tttaattcca cactctcatt   1380

aataaattga ataaaaggga atgttttggc acctgatata atctgccagg ctatgtgaca   1440

gtaggaagga atggtttccc ctaacaagcc caatgcactg gtctgacttt ataaattatt   1500

taataaaatg aactattatc aaataaaacg tatgaatcag tccttta                 1547


<210>  1119
<211>  219
<212>  PRT
<213>  Homo sapiens

<400>  1119


Met Ala Ser Gly Ser Asn Trp Leu Ser Gly Val Asn Val Val Leu Val 
1               5                   10                  15      


Met Ala Tyr Gly Ser Leu Asp Leu Lys Glu Glu Ile Asp Ile Arg Leu 
            20                  25                  30          


Ser Arg Val Gln Asp Ile Lys Tyr Glu Pro Gln Leu Leu Ala Asp Asp 
        35                  40                  45              


Asp Ala Arg Leu Leu Gln Leu Glu Thr Gln Gly Asn Gln Ser Cys Tyr 
    50                  55                  60                  


Asn Tyr Leu Tyr Arg Met Lys Ala Leu Asp Ala Ile Arg Thr Ser Glu 
65                  70                  75                  80  


Ile Pro Phe His Ser Glu Gly Arg His Pro Arg Ser Leu Met Gly Lys 
                85                  90                  95      


Asn Phe Arg Ser Tyr Leu Leu Asp Leu Arg Asn Thr Ser Thr Pro Phe 
            100                 105                 110         


Lys Gly Val Arg Lys Ala Leu Ile Asp Thr Leu Leu Asp Gly Tyr Glu 
        115                 120                 125             


Thr Ala Arg Tyr Gly Thr Gly Val Phe Gly Gln Asn Glu Tyr Leu Arg 
    130                 135                 140                 


Tyr Gln Glu Ala Leu Ser Glu Leu Ala Thr Ala Val Lys Ala Arg Ile 
145                 150                 155                 160 


Gly Ser Ser Gln Arg His His Gln Ser Ala Ala Lys Asp Leu Thr Gln 
                165                 170                 175     


Ser Pro Glu Val Ser Pro Thr Thr Ile Gln Val Thr Tyr Leu Pro Ser 
            180                 185                 190         


Ser Gln Lys Ser Lys Arg Ala Lys His Phe Leu Glu Leu Lys Ser Phe 
        195                 200                 205             


Lys Asp Asn Tyr Asn Thr Leu Glu Ser Thr Leu 
    210                 215                 

<210>  1120
<211>  715
<212>  DNA
<213>  Homo sapiens

<400>  1120
gggttaaagc acgaattggg agctctcagc gacatcacca gtcagcagcc aaagacctaa     60

ctcagtcccc tgaggtctcc ccaacaacca tccaggtgac atacctcccc tccagtcaga    120

agagtaaacg tgccaagcac ttccttgaat tgaagagctt taaggataac tataacacat    180

tggagagtac tctgtgacgg agctgaagga ctcttgccgt agattaagcc agtcagttgc    240

aatgtgcaag acaggctgct tgccgggccg ccctcggaac atctggccca gcaggcccag    300

actgtatcca tccaagttcc cgttgtatcc agagttctta gagcttgtgt ctaaagggta    360

attccccaac ccttccttat gagcattttt agaacattgg ctaagactat tttcccccag    420

tagcgctttt ttctggattt gcattcaggt gttattctta atgtttctgt caaagcttct    480

taaaaatctt cacttggttt cagccatagt tcaccttccc tgttccaggt ttatttaatt    540

ccacactctc attaataaat tgaataaaag ggaatgtttt ggcacctgat ataatctgcc    600

aggctatgtg acagtaggaa ggaatggttt cccctaacaa gcccaatgca ctggtctgac    660

tttataaatt atttaataaa atgaactatt atcaaataaa acgtatgaat cagtc         715


<210>  1121
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  1121


Met Cys Lys Thr Gly Cys Leu Pro Gly Arg Pro Arg Asn Ile Trp Pro 
1               5                   10                  15      


Ser Arg Pro Arg Leu Tyr Pro Ser Lys Phe Pro Leu Tyr Pro Glu Phe 
            20                  25                  30          


Leu Glu Leu Val Ser Lys Gly 
        35                  

<210>  1122
<211>  3411
<212>  DNA
<213>  Homo sapiens

<400>  1122
cccgactaag tgacttaaac tcccacctac tcctggaata aggagtcaaa gcccggatag     60

gcgcagtatt ctaccttgta aatactgtta tttgtatata ctgtaaatga tgacatcggt    120

gggcactaac cgagcccggg gaaactggga acaacctcaa aaccaaaacc agacacagca    180

caagcagcgg ccacaggcca ctgcagaaca aattagactt gcacagatga tttcggacca    240

taatgatgct gactttgagg agaaggtgaa acaattgatt gatattacag gcaagaacca    300

ggatgaatgt gtgattgctt tgcatgactg caatggagat gtcaacagag ctatcaatgt    360

tcttctggaa ggaaacccag acacgcattc ctgggagatg gtcgggaaga agaagggagt    420

ctcaggccag aaggatggtg gccagacgga atccaatgag gaaggcaaag aaaatcgaga    480

ccgggacaga gactatagtc ggcgacgtgg tgggccacca agacggggga gaggtgccag    540

ccgtggacga gagtttcgag gtcaggaaaa tggattggat ggcaccaaga gtggagggcc    600

ttctggaaga ggaacagaaa gaggcagaag gggccgtggc cgaggcagag gtggctctgg    660

taggcgagga ggaaggtttt ctgctcaagg aatgggaacc tttaacccag ctgattatgc    720

agagccagcc aatactgatg ataactatgg caatagcagc ggcaatacgt ggaacaacac    780

tggccacttt gaaccagatg atgggacgag tgcatggagg actgcaacag aggagtgggg    840

gactgaagat tggaatgaag atctttctga gaccaagatc ttcactgcct ctaatgtgtc    900

ttcagtgcct ctgcctgcgg agaatgtgac aatcactgct ggtcagagaa ttgaccttgc    960

tgttctgctg gggaagacac catctacaat ggagaatgat tcatctaatc tggatccgtc   1020

tcaggctcct tctctggccc agcctctggt gttcagtaat tcgaagcaga ctgccatatc   1080

acagcctgct tcagggaaca cattttctca tcacagtatg gtgagcatgt tagggaaagg   1140

atttggtgat gtcggtgaag ctaaaggcgg cagtactaca ggctcccagt tcttggagca   1200

attcaagact gcccaagccc tggctcagtt ggcagctcag cattctcagt ctggaagcac   1260

caccacctcc tcttgggaca tgggctcgac gacacaatcc ccatcactgg tgcagtatga   1320

tttgaagaac ccaagtgatt cagcagtgca cagccccttt acaaagcgcc aggcttttac   1380

cccatcttca accatgatgg aggtgttcct tcaggagaag tcacctgcag tggctacctc   1440

cacagctgca cctccacctc cgtcttctcc tctgccaagc aaatccacat cggctccaca   1500

gatgtcgcct ggatcttcag acaaccagtc ctctagccct cagccggctc agcagaaact   1560

gaaacagcag aagaaaaaag cctccttgac ttctaagatt cctgctctgg ctgtggagat   1620

gcctggctca gcagatatct cagggctaaa cctgcagttt ggggcattgc agtttgggtc   1680

agagcctgtc ctttctgatt atgagtccac ccccaccacg agcgcctctt caagccaggc   1740

tccaagtagc ctgtatacca gcacggccag tgaatcatcc tctacaattt catctaacca   1800

gagtcaggag tctggttatc agagcggccc aattcagtcg acaacctata cctcccaaaa   1860

taatgctcag ggccctcttt atgaacagag atccacacag actcggcggt accccagctc   1920

catctcttca tcaccccaaa aggacctgac tcaggcaaag aatggcttca gttctgtgca   1980

ggccacgcag ttacagacca cacaatctgt tgaaggtgct acaggctctg cagtgaaatc   2040

tgattcacct tccacttcta gcatcccccc tctcaatgaa acggtatctg cagcttcctt   2100

actgacgaca accaatcagc attcatcctc cttgggtggc ttgagccaca gtgaggagat   2160

tccaaatact accaccacac aacacagcag cacgttatct acgcagcaga ataccctttc   2220

atcatcaaca tcttctgggc gcacttcgac atccactctt ttgcacacaa gtgtggagag   2280

tgaggcgaat ctccattctt cctccagcac tttttccacc acatccagca cagtctctgc   2340

acctccccca gtggtcagtg tctcctccag tctcaatagt ggcagtagcc tgggcctcag   2400

cctaggcagc aactccactg tcacagcctc gactcgaagc tcagttgcta cgacttcagg   2460

aaaagctcct cccaacctcc ctcctggggt cccgccgttg ttgcctaatc cgtatattat   2520

ggctccaggg ctgttacatg cctacccgcc acaagtatat ggttatgatg acttgcagat   2580

gcttcagaca agatttccat tggattacta cagcatccca tttcccacac ccactactcc   2640

gctgactggg agggatggta gcctggccag caacccttat tctggtgacc tcacaaagtt   2700

cggccgtggg gatgcctcct ccccagcccc ggccacaacc ttggcccaac cccaacagaa   2760

ccagacgcag actcaccata ccacgcagca gacattcctg aacccggcgc tgcctcctgg   2820

ctacagttac accagcctgc catactatac aggggtcccg ggcctcccca gcaccttcca   2880

gtatgggcct gctgtgttcc ctgtggctcc tacctcttcc aagcagcatg gtgtgaatgt   2940

cagtgtgaat gcatcggcca cccctttcca acagccgagt ggatatgggt ctcatggata   3000

caacactgga agaaaatatc caccccctta caagcatttc tggacggctg agagctaatt   3060

tggcccaagg ctgggggctg tgttttgtgt gtgtgtataa atttgcactg aagtcttgtt   3120

tcagaaacca gaccactgag gagagcctgc tgagctgagg ccatggcctg cgtggcttgg   3180

ggaaatgagt tggtggatac cttctgggct tttgaacttg cccctccccc atttccctct   3240

cccccatgtg tctgaccctg tcttacccat ttcaagttca agcggtgcag caccttcgaa   3300

gcatcaatgc acacacctgc tgttgctttt gatttctgga aggcatgtag tttcaacttg   3360

taacaaaaat atttgtagtc ttcaataaac tgtggtattt ctttagctaa c            3411


<210>  1123
<211>  983
<212>  PRT
<213>  Homo sapiens

<400>  1123


Met Met Thr Ser Val Gly Thr Asn Arg Ala Arg Gly Asn Trp Glu Gln 
1               5                   10                  15      


Pro Gln Asn Gln Asn Gln Thr Gln His Lys Gln Arg Pro Gln Ala Thr 
            20                  25                  30          


Ala Glu Gln Ile Arg Leu Ala Gln Met Ile Ser Asp His Asn Asp Ala 
        35                  40                  45              


Asp Phe Glu Glu Lys Val Lys Gln Leu Ile Asp Ile Thr Gly Lys Asn 
    50                  55                  60                  


Gln Asp Glu Cys Val Ile Ala Leu His Asp Cys Asn Gly Asp Val Asn 
65                  70                  75                  80  


Arg Ala Ile Asn Val Leu Leu Glu Gly Asn Pro Asp Thr His Ser Trp 
                85                  90                  95      


Glu Met Val Gly Lys Lys Lys Gly Val Ser Gly Gln Lys Asp Gly Gly 
            100                 105                 110         


Gln Thr Glu Ser Asn Glu Glu Gly Lys Glu Asn Arg Asp Arg Asp Arg 
        115                 120                 125             


Asp Tyr Ser Arg Arg Arg Gly Gly Pro Pro Arg Arg Gly Arg Gly Ala 
    130                 135                 140                 


Ser Arg Gly Arg Glu Phe Arg Gly Gln Glu Asn Gly Leu Asp Gly Thr 
145                 150                 155                 160 


Lys Ser Gly Gly Pro Ser Gly Arg Gly Thr Glu Arg Gly Arg Arg Gly 
                165                 170                 175     


Arg Gly Arg Gly Arg Gly Gly Ser Gly Arg Arg Gly Gly Arg Phe Ser 
            180                 185                 190         


Ala Gln Gly Met Gly Thr Phe Asn Pro Ala Asp Tyr Ala Glu Pro Ala 
        195                 200                 205             


Asn Thr Asp Asp Asn Tyr Gly Asn Ser Ser Gly Asn Thr Trp Asn Asn 
    210                 215                 220                 


Thr Gly His Phe Glu Pro Asp Asp Gly Thr Ser Ala Trp Arg Thr Ala 
225                 230                 235                 240 


Thr Glu Glu Trp Gly Thr Glu Asp Trp Asn Glu Asp Leu Ser Glu Thr 
                245                 250                 255     


Lys Ile Phe Thr Ala Ser Asn Val Ser Ser Val Pro Leu Pro Ala Glu 
            260                 265                 270         


Asn Val Thr Ile Thr Ala Gly Gln Arg Ile Asp Leu Ala Val Leu Leu 
        275                 280                 285             


Gly Lys Thr Pro Ser Thr Met Glu Asn Asp Ser Ser Asn Leu Asp Pro 
    290                 295                 300                 


Ser Gln Ala Pro Ser Leu Ala Gln Pro Leu Val Phe Ser Asn Ser Lys 
305                 310                 315                 320 


Gln Thr Ala Ile Ser Gln Pro Ala Ser Gly Asn Thr Phe Ser His His 
                325                 330                 335     


Ser Met Val Ser Met Leu Gly Lys Gly Phe Gly Asp Val Gly Glu Ala 
            340                 345                 350         


Lys Gly Gly Ser Thr Thr Gly Ser Gln Phe Leu Glu Gln Phe Lys Thr 
        355                 360                 365             


Ala Gln Ala Leu Ala Gln Leu Ala Ala Gln His Ser Gln Ser Gly Ser 
    370                 375                 380                 


Thr Thr Thr Ser Ser Trp Asp Met Gly Ser Thr Thr Gln Ser Pro Ser 
385                 390                 395                 400 


Leu Val Gln Tyr Asp Leu Lys Asn Pro Ser Asp Ser Ala Val His Ser 
                405                 410                 415     


Pro Phe Thr Lys Arg Gln Ala Phe Thr Pro Ser Ser Thr Met Met Glu 
            420                 425                 430         


Val Phe Leu Gln Glu Lys Ser Pro Ala Val Ala Thr Ser Thr Ala Ala 
        435                 440                 445             


Pro Pro Pro Pro Ser Ser Pro Leu Pro Ser Lys Ser Thr Ser Ala Pro 
    450                 455                 460                 


Gln Met Ser Pro Gly Ser Ser Asp Asn Gln Ser Ser Ser Pro Gln Pro 
465                 470                 475                 480 


Ala Gln Gln Lys Leu Lys Gln Gln Lys Lys Lys Ala Ser Leu Thr Ser 
                485                 490                 495     


Lys Ile Pro Ala Leu Ala Val Glu Met Pro Gly Ser Ala Asp Ile Ser 
            500                 505                 510         


Gly Leu Asn Leu Gln Phe Gly Ala Leu Gln Phe Gly Ser Glu Pro Val 
        515                 520                 525             


Leu Ser Asp Tyr Glu Ser Thr Pro Thr Thr Ser Ala Ser Ser Ser Gln 
    530                 535                 540                 


Ala Pro Ser Ser Leu Tyr Thr Ser Thr Ala Ser Glu Ser Ser Ser Thr 
545                 550                 555                 560 


Ile Ser Ser Asn Gln Ser Gln Glu Ser Gly Tyr Gln Ser Gly Pro Ile 
                565                 570                 575     


Gln Ser Thr Thr Tyr Thr Ser Gln Asn Asn Ala Gln Gly Pro Leu Tyr 
            580                 585                 590         


Glu Gln Arg Ser Thr Gln Thr Arg Arg Tyr Pro Ser Ser Ile Ser Ser 
        595                 600                 605             


Ser Pro Gln Lys Asp Leu Thr Gln Ala Lys Asn Gly Phe Ser Ser Val 
    610                 615                 620                 


Gln Ala Thr Gln Leu Gln Thr Thr Gln Ser Val Glu Gly Ala Thr Gly 
625                 630                 635                 640 


Ser Ala Val Lys Ser Asp Ser Pro Ser Thr Ser Ser Ile Pro Pro Leu 
                645                 650                 655     


Asn Glu Thr Val Ser Ala Ala Ser Leu Leu Thr Thr Thr Asn Gln His 
            660                 665                 670         


Ser Ser Ser Leu Gly Gly Leu Ser His Ser Glu Glu Ile Pro Asn Thr 
        675                 680                 685             


Thr Thr Thr Gln His Ser Ser Thr Leu Ser Thr Gln Gln Asn Thr Leu 
    690                 695                 700                 


Ser Ser Ser Thr Ser Ser Gly Arg Thr Ser Thr Ser Thr Leu Leu His 
705                 710                 715                 720 


Thr Ser Val Glu Ser Glu Ala Asn Leu His Ser Ser Ser Ser Thr Phe 
                725                 730                 735     


Ser Thr Thr Ser Ser Thr Val Ser Ala Pro Pro Pro Val Val Ser Val 
            740                 745                 750         


Ser Ser Ser Leu Asn Ser Gly Ser Ser Leu Gly Leu Ser Leu Gly Ser 
        755                 760                 765             


Asn Ser Thr Val Thr Ala Ser Thr Arg Ser Ser Val Ala Thr Thr Ser 
    770                 775                 780                 


Gly Lys Ala Pro Pro Asn Leu Pro Pro Gly Val Pro Pro Leu Leu Pro 
785                 790                 795                 800 


Asn Pro Tyr Ile Met Ala Pro Gly Leu Leu His Ala Tyr Pro Pro Gln 
                805                 810                 815     


Val Tyr Gly Tyr Asp Asp Leu Gln Met Leu Gln Thr Arg Phe Pro Leu 
            820                 825                 830         


Asp Tyr Tyr Ser Ile Pro Phe Pro Thr Pro Thr Thr Pro Leu Thr Gly 
        835                 840                 845             


Arg Asp Gly Ser Leu Ala Ser Asn Pro Tyr Ser Gly Asp Leu Thr Lys 
    850                 855                 860                 


Phe Gly Arg Gly Asp Ala Ser Ser Pro Ala Pro Ala Thr Thr Leu Ala 
865                 870                 875                 880 


Gln Pro Gln Gln Asn Gln Thr Gln Thr His His Thr Thr Gln Gln Thr 
                885                 890                 895     


Phe Leu Asn Pro Ala Leu Pro Pro Gly Tyr Ser Tyr Thr Ser Leu Pro 
            900                 905                 910         


Tyr Tyr Thr Gly Val Pro Gly Leu Pro Ser Thr Phe Gln Tyr Gly Pro 
        915                 920                 925             


Ala Val Phe Pro Val Ala Pro Thr Ser Ser Lys Gln His Gly Val Asn 
    930                 935                 940                 


Val Ser Val Asn Ala Ser Ala Thr Pro Phe Gln Gln Pro Ser Gly Tyr 
945                 950                 955                 960 


Gly Ser His Gly Tyr Asn Thr Gly Arg Lys Tyr Pro Pro Pro Tyr Lys 
                965                 970                 975     


His Phe Trp Thr Ala Glu Ser 
            980             

<210>  1124
<211>  3987
<212>  DNA
<213>  Homo sapiens

<400>  1124
ggcagggccg ccgtgaagga ggcggggtgg actcgcggag ccggaaagag gtgtctcgtg     60

gcgaggcggc acgcgcacgc ttgcgtgcgc gcccctttta gcgtcacgcg ctgagggacc    120

tttcagtatt ctaccttgta aatactgtta tttgtatata ctgtaaatga tgacatcggt    180

gggcactaac cgagcccggg gaaactggga acaacctcaa aaccaaaacc agacacagca    240

caagcagcgg ccacaggcca ctgcagaaca aattagactt gcacagatga tttcggacca    300

taatgatgct gactttgagg agaaggtgaa acaattgatt gatattacag gcaagaacca    360

ggatgaatgt gtgattgctt tgcatgactg caatggagat gtcaacagag ctatcaatgt    420

tcttctggaa ggaaacccag acacgcattc ctgggagatg gtcgggaaga agaagggagt    480

ctcaggccag aaggatggtg gccagacgga atccaatgag gaaggcaaag aaaatcgaga    540

ccgggacaga gactatagtc ggcgacgtgg tgggccacca agacggggga gaggtgccag    600

ccgtggacga gagtttcgag gtcaggaaaa tggattggat ggcaccaaga gtggagggcc    660

ttctggaaga ggaacagaaa gaggcagaag gggccgtggc cgaggcagag gtggctctgg    720

taggcgagga ggaaggtttt ctgctcaagg aatgggaacc tttaacccag ctgattatgc    780

agagccagcc aatactgatg ataactatgg caatagcagc ggcaatacgt ggaacaacac    840

tggccacttt gaaccagatg atgggacgag tgcatggagg actgcaacag aggagtgggg    900

gactgaagat tggaatgaag atctttctga gaccaagatc ttcactgcct ctaatgtgtc    960

ttcagtgcct ctgcctgcgg agaatgtgac aatcactgct ggtcagagaa ttgaccttgc   1020

tgttctgctg gggaagacac catctacaat ggagaatgat tcatctaatc tggatccgtc   1080

tcaggctcct tctctggccc agcctctggt gttcagtaat tcgaagcaga ctgccatatc   1140

acagcctgct tcagggaaca cattttctca tcacagtatg gtgagcatgt tagggaaagg   1200

atttggtgat gtcggtgaag ctaaaggcgg cagtactaca ggctcccagt tcttggagca   1260

attcaagact gcccaagccc tggctcagtt ggcagctcag cattctcagt ctggaagcac   1320

caccacctcc tcttgggaca tgggctcgac gacacaatcc ccatcactgg tgcagtatga   1380

tttgaagaac ccaagtgatt cagcagtgca cagccccttt acaaagcgcc aggcttttac   1440

cccatcttca accatgatgg aggtgttcct tcaggagaag tcacctgcag tggctacctc   1500

cacagctgca cctccacctc cgtcttctcc tctgccaagc aaatccacat cggctccaca   1560

gatgtcgcct ggatcttcag acaaccagtc ctctagccct cagccggctc agcagaaact   1620

gaaacagcag aagaaaaaag cctccttgac ttctaagatt cctgctctgg ctgtggagat   1680

gcctggctca gcagatatct cagggctaaa cctgcagttt ggggcattgc agtttgggtc   1740

agagcctgtc ctttctgatt atgagtccac ccccaccacg agcgcctctt caagccaggc   1800

tccaagtagc ctgtatacca gcacggccag tgaatcatcc tctacaattt catctaacca   1860

gagtcaggag tctggttatc agagcggccc aattcagtcg acaacctata cctcccaaaa   1920

taatgctcag ggccctcttt atgaacagag atccacacag actcggcggt accccagctc   1980

catctcttca tcaccccaaa aggacctgac tcaggcaaag aatggcttca gttctgtgca   2040

ggccacgcag ttacagacca cacaatctgt tgaaggtgct acaggctctg cagtgaaatc   2100

tgattcacct tccacttcta gcatcccccc tctcaatgaa acggtatctg cagcttcctt   2160

actgacgaca accaatcagc attcatcctc cttgggtggc ttgagccaca gtgaggagat   2220

tccaaatact accaccacac aacacagcag cacgttatct acgcagcaga ataccctttc   2280

atcatcaaca tcttctgggc gcacttcgac atccactctt ttgcacacaa gtgtggagag   2340

tgaggcgaat ctccattctt cctccagcac tttttccacc acatccagca cagtctctgc   2400

acctccccca gtggtcagtg tctcctccag tctcaatagt ggcagtagcc tgggcctcag   2460

cctaggcagc aactccactg tcacagcctc gactcgaagc tcagttgcta cgacttcagg   2520

aaaagctcct cccaacctcc ctcctggggt cccgccgttg ttgcctaatc cgtatattat   2580

ggctccaggg ctgttacatg cctacccgcc acaagtatat ggttatgatg acttgcagat   2640

gcttcagaca agatttccat tggattacta cagcatccca tttcccacac ccactactcc   2700

gctgactggg agggatggta gcctggccag caacccttat tctggtgacc tcacaaagtt   2760

cggccgtggg gatgcctcct ccccagcccc ggccacaacc ttggcccaac cccaacagaa   2820

ccagacgcag actcaccata ccacgcagca gacattcctg aacccggcgc tgcctcctgg   2880

ctacagttac accagcctgc catactatac aggggtcccg ggcctcccca gcaccttcca   2940

gtatgggcct gctgtgttcc ctgtggctcc tacctcttcc aagcagcatg gtgtgaatgt   3000

cagtgtgaat gcatcggcca cccctttcca acagccgagt ggatatgggt ctcatggata   3060

caacactggt gtttcagtca cctccagtaa cacgggcgtg ccagatatct cgggttctgt   3120

gtactccaaa acccagcagt cctttgagaa acaaggtttt cattccggta ctcctgctgc   3180

ttccttcaac ttgccttcag ccctaggaag tgggggcccc atcaatccgg ccacagctgc   3240

tgcctaccca cctgccccct ttatgcacat tctgaccccc catcagcagc cgcattctca   3300

gatccttcac catcacctgc agcaggatgg ccagacgggc agcgggcaac gtagccagac   3360

cagctccatc ccgcagaagc cccagaccaa caagtctgcc tacaacagct acagctgggg   3420

ggccaactga ggccctgacc ctcttctccc ggtcccatct tctgagaggg cttctcagcc   3480

tggaaactat ggaaacagca tcaaagagaa aggaatgtgg ggggtttccg ctgcccccca   3540

cccccagcgg cccaccccat gcctcagctt catgtctgtc ccattcctat accatcccca   3600

ccctgttgta tgtattatag gatttgtatt ttctcctttt ttttccccct tccattcctt   3660

ctcccctctt gcattcaaga ttatgaaact ttgctatggg ccctgcactt cctttgcttc   3720

ctcctgttca ccctggtggt gtacggatga ggcggggagg tgggaccccc aaacatatat   3780

cagcccaaca gccctaagtc tccttcttta ttattaggaa aacaacaaca acaacaaaca   3840

aaaaaatggc gtcatgaata tgaacagcat tgtcagatga attagttgaa gtggtttttt   3900

ttttgttttt tttttttttt tgtactgtgt cctcaaattt aatggattaa tgtgtcttgt   3960

atatataaaa agaaaacctc taccttc                                       3987


<210>  1125
<211>  1087
<212>  PRT
<213>  Homo sapiens

<400>  1125


Met Met Thr Ser Val Gly Thr Asn Arg Ala Arg Gly Asn Trp Glu Gln 
1               5                   10                  15      


Pro Gln Asn Gln Asn Gln Thr Gln His Lys Gln Arg Pro Gln Ala Thr 
            20                  25                  30          


Ala Glu Gln Ile Arg Leu Ala Gln Met Ile Ser Asp His Asn Asp Ala 
        35                  40                  45              


Asp Phe Glu Glu Lys Val Lys Gln Leu Ile Asp Ile Thr Gly Lys Asn 
    50                  55                  60                  


Gln Asp Glu Cys Val Ile Ala Leu His Asp Cys Asn Gly Asp Val Asn 
65                  70                  75                  80  


Arg Ala Ile Asn Val Leu Leu Glu Gly Asn Pro Asp Thr His Ser Trp 
                85                  90                  95      


Glu Met Val Gly Lys Lys Lys Gly Val Ser Gly Gln Lys Asp Gly Gly 
            100                 105                 110         


Gln Thr Glu Ser Asn Glu Glu Gly Lys Glu Asn Arg Asp Arg Asp Arg 
        115                 120                 125             


Asp Tyr Ser Arg Arg Arg Gly Gly Pro Pro Arg Arg Gly Arg Gly Ala 
    130                 135                 140                 


Ser Arg Gly Arg Glu Phe Arg Gly Gln Glu Asn Gly Leu Asp Gly Thr 
145                 150                 155                 160 


Lys Ser Gly Gly Pro Ser Gly Arg Gly Thr Glu Arg Gly Arg Arg Gly 
                165                 170                 175     


Arg Gly Arg Gly Arg Gly Gly Ser Gly Arg Arg Gly Gly Arg Phe Ser 
            180                 185                 190         


Ala Gln Gly Met Gly Thr Phe Asn Pro Ala Asp Tyr Ala Glu Pro Ala 
        195                 200                 205             


Asn Thr Asp Asp Asn Tyr Gly Asn Ser Ser Gly Asn Thr Trp Asn Asn 
    210                 215                 220                 


Thr Gly His Phe Glu Pro Asp Asp Gly Thr Ser Ala Trp Arg Thr Ala 
225                 230                 235                 240 


Thr Glu Glu Trp Gly Thr Glu Asp Trp Asn Glu Asp Leu Ser Glu Thr 
                245                 250                 255     


Lys Ile Phe Thr Ala Ser Asn Val Ser Ser Val Pro Leu Pro Ala Glu 
            260                 265                 270         


Asn Val Thr Ile Thr Ala Gly Gln Arg Ile Asp Leu Ala Val Leu Leu 
        275                 280                 285             


Gly Lys Thr Pro Ser Thr Met Glu Asn Asp Ser Ser Asn Leu Asp Pro 
    290                 295                 300                 


Ser Gln Ala Pro Ser Leu Ala Gln Pro Leu Val Phe Ser Asn Ser Lys 
305                 310                 315                 320 


Gln Thr Ala Ile Ser Gln Pro Ala Ser Gly Asn Thr Phe Ser His His 
                325                 330                 335     


Ser Met Val Ser Met Leu Gly Lys Gly Phe Gly Asp Val Gly Glu Ala 
            340                 345                 350         


Lys Gly Gly Ser Thr Thr Gly Ser Gln Phe Leu Glu Gln Phe Lys Thr 
        355                 360                 365             


Ala Gln Ala Leu Ala Gln Leu Ala Ala Gln His Ser Gln Ser Gly Ser 
    370                 375                 380                 


Thr Thr Thr Ser Ser Trp Asp Met Gly Ser Thr Thr Gln Ser Pro Ser 
385                 390                 395                 400 


Leu Val Gln Tyr Asp Leu Lys Asn Pro Ser Asp Ser Ala Val His Ser 
                405                 410                 415     


Pro Phe Thr Lys Arg Gln Ala Phe Thr Pro Ser Ser Thr Met Met Glu 
            420                 425                 430         


Val Phe Leu Gln Glu Lys Ser Pro Ala Val Ala Thr Ser Thr Ala Ala 
        435                 440                 445             


Pro Pro Pro Pro Ser Ser Pro Leu Pro Ser Lys Ser Thr Ser Ala Pro 
    450                 455                 460                 


Gln Met Ser Pro Gly Ser Ser Asp Asn Gln Ser Ser Ser Pro Gln Pro 
465                 470                 475                 480 


Ala Gln Gln Lys Leu Lys Gln Gln Lys Lys Lys Ala Ser Leu Thr Ser 
                485                 490                 495     


Lys Ile Pro Ala Leu Ala Val Glu Met Pro Gly Ser Ala Asp Ile Ser 
            500                 505                 510         


Gly Leu Asn Leu Gln Phe Gly Ala Leu Gln Phe Gly Ser Glu Pro Val 
        515                 520                 525             


Leu Ser Asp Tyr Glu Ser Thr Pro Thr Thr Ser Ala Ser Ser Ser Gln 
    530                 535                 540                 


Ala Pro Ser Ser Leu Tyr Thr Ser Thr Ala Ser Glu Ser Ser Ser Thr 
545                 550                 555                 560 


Ile Ser Ser Asn Gln Ser Gln Glu Ser Gly Tyr Gln Ser Gly Pro Ile 
                565                 570                 575     


Gln Ser Thr Thr Tyr Thr Ser Gln Asn Asn Ala Gln Gly Pro Leu Tyr 
            580                 585                 590         


Glu Gln Arg Ser Thr Gln Thr Arg Arg Tyr Pro Ser Ser Ile Ser Ser 
        595                 600                 605             


Ser Pro Gln Lys Asp Leu Thr Gln Ala Lys Asn Gly Phe Ser Ser Val 
    610                 615                 620                 


Gln Ala Thr Gln Leu Gln Thr Thr Gln Ser Val Glu Gly Ala Thr Gly 
625                 630                 635                 640 


Ser Ala Val Lys Ser Asp Ser Pro Ser Thr Ser Ser Ile Pro Pro Leu 
                645                 650                 655     


Asn Glu Thr Val Ser Ala Ala Ser Leu Leu Thr Thr Thr Asn Gln His 
            660                 665                 670         


Ser Ser Ser Leu Gly Gly Leu Ser His Ser Glu Glu Ile Pro Asn Thr 
        675                 680                 685             


Thr Thr Thr Gln His Ser Ser Thr Leu Ser Thr Gln Gln Asn Thr Leu 
    690                 695                 700                 


Ser Ser Ser Thr Ser Ser Gly Arg Thr Ser Thr Ser Thr Leu Leu His 
705                 710                 715                 720 


Thr Ser Val Glu Ser Glu Ala Asn Leu His Ser Ser Ser Ser Thr Phe 
                725                 730                 735     


Ser Thr Thr Ser Ser Thr Val Ser Ala Pro Pro Pro Val Val Ser Val 
            740                 745                 750         


Ser Ser Ser Leu Asn Ser Gly Ser Ser Leu Gly Leu Ser Leu Gly Ser 
        755                 760                 765             


Asn Ser Thr Val Thr Ala Ser Thr Arg Ser Ser Val Ala Thr Thr Ser 
    770                 775                 780                 


Gly Lys Ala Pro Pro Asn Leu Pro Pro Gly Val Pro Pro Leu Leu Pro 
785                 790                 795                 800 


Asn Pro Tyr Ile Met Ala Pro Gly Leu Leu His Ala Tyr Pro Pro Gln 
                805                 810                 815     


Val Tyr Gly Tyr Asp Asp Leu Gln Met Leu Gln Thr Arg Phe Pro Leu 
            820                 825                 830         


Asp Tyr Tyr Ser Ile Pro Phe Pro Thr Pro Thr Thr Pro Leu Thr Gly 
        835                 840                 845             


Arg Asp Gly Ser Leu Ala Ser Asn Pro Tyr Ser Gly Asp Leu Thr Lys 
    850                 855                 860                 


Phe Gly Arg Gly Asp Ala Ser Ser Pro Ala Pro Ala Thr Thr Leu Ala 
865                 870                 875                 880 


Gln Pro Gln Gln Asn Gln Thr Gln Thr His His Thr Thr Gln Gln Thr 
                885                 890                 895     


Phe Leu Asn Pro Ala Leu Pro Pro Gly Tyr Ser Tyr Thr Ser Leu Pro 
            900                 905                 910         


Tyr Tyr Thr Gly Val Pro Gly Leu Pro Ser Thr Phe Gln Tyr Gly Pro 
        915                 920                 925             


Ala Val Phe Pro Val Ala Pro Thr Ser Ser Lys Gln His Gly Val Asn 
    930                 935                 940                 


Val Ser Val Asn Ala Ser Ala Thr Pro Phe Gln Gln Pro Ser Gly Tyr 
945                 950                 955                 960 


Gly Ser His Gly Tyr Asn Thr Gly Val Ser Val Thr Ser Ser Asn Thr 
                965                 970                 975     


Gly Val Pro Asp Ile Ser Gly Ser Val Tyr Ser Lys Thr Gln Gln Ser 
            980                 985                 990         


Phe Glu Lys Gln Gly Phe His Ser  Gly Thr Pro Ala Ala  Ser Phe Asn 
        995                 1000                 1005             


Leu Pro  Ser Ala Leu Gly Ser  Gly Gly Pro Ile Asn  Pro Ala Thr 
    1010                 1015                 1020             


Ala Ala  Ala Tyr Pro Pro Ala  Pro Phe Met His Ile  Leu Thr Pro 
    1025                 1030                 1035             


His Gln  Gln Pro His Ser Gln  Ile Leu His His His  Leu Gln Gln 
    1040                 1045                 1050             


Asp Gly  Gln Thr Gly Ser Gly  Gln Arg Ser Gln Thr  Ser Ser Ile 
    1055                 1060                 1065             


Pro Gln  Lys Pro Gln Thr Asn  Lys Ser Ala Tyr Asn  Ser Tyr Ser 
    1070                 1075                 1080             


Trp Gly  Ala Asn 
    1085         

<210>  1126
<211>  1128
<212>  DNA
<213>  Homo sapiens

<400>  1126
atgcggctag agcctgagag gggagagcga gaaagagcgc gagcgagcga ggcctgggcc     60

ttgcctgagt attctacctt gtaaatactg ttatttgtat atactgtaaa tgatgacatc    120

ggtgggcact aaccgagccc ggggaaactg ggaacaacct caaaaccaaa accagacaca    180

gcacaagcag cggccacagg ccactgcaga acaaattaga cttgcacaga tgatttcgga    240

ccataatgat gctgactttg aggagaaggt gaaacaattg attgatatta caggcaagaa    300

ccaggatgaa tgtgtgattg ctttgcatga ctgcaatgga gatgtcaaca gagctatcaa    360

tgttcttctg gaaggaaacc cagacacgca ttcctgggag atggtcggga agaagaaggg    420

agtctcaggc cagaaggatg gtggccagac ggaatccaat gaggaaggca aagaaaatcg    480

agaccgggac agagactata gtcggcgacg tggtgggcca ccaagacggg ggagaggtgc    540

cagccgtgga cgagagtttc gaggtcagga aaatggattg gatggcacca agagtggagg    600

gccttctgga agaggaacag aaagaggcag aaggggccgt ggccgaggca gaggtggctc    660

tggtaggcga ggaggaaggt tttctgctca aggaatggga acctttaacc cagctgatta    720

tgcagagcca gccaatactg atgataacta tggcaatagc agcggcaata cgtggaacaa    780

cactggccac tttgaaccag atgatgggac gagtgagtga ccatttatca ttcatttctt    840

gtctctggga atctaaggaa atagtttttt ctgattatac ttacattaaa acgtggaaga    900

atagtgtttg gttatggaga tagggtgaga aagggctggc agttgtatta ctgtgtgtac    960

tgtttatgta acgtgcatat gggcacatta cacatgttat ttcgcttaat gctgcttgat   1020

attgtatgaa ataatcatta tttatcatca ctttccagat gacaaaacta aggccgaaag   1080

agaggttata aatttgctag tatttgaact cagcattgtt tgaccctg                1128


<210>  1127
<211>  236
<212>  PRT
<213>  Homo sapiens

<400>  1127


Met Met Thr Ser Val Gly Thr Asn Arg Ala Arg Gly Asn Trp Glu Gln 
1               5                   10                  15      


Pro Gln Asn Gln Asn Gln Thr Gln His Lys Gln Arg Pro Gln Ala Thr 
            20                  25                  30          


Ala Glu Gln Ile Arg Leu Ala Gln Met Ile Ser Asp His Asn Asp Ala 
        35                  40                  45              


Asp Phe Glu Glu Lys Val Lys Gln Leu Ile Asp Ile Thr Gly Lys Asn 
    50                  55                  60                  


Gln Asp Glu Cys Val Ile Ala Leu His Asp Cys Asn Gly Asp Val Asn 
65                  70                  75                  80  


Arg Ala Ile Asn Val Leu Leu Glu Gly Asn Pro Asp Thr His Ser Trp 
                85                  90                  95      


Glu Met Val Gly Lys Lys Lys Gly Val Ser Gly Gln Lys Asp Gly Gly 
            100                 105                 110         


Gln Thr Glu Ser Asn Glu Glu Gly Lys Glu Asn Arg Asp Arg Asp Arg 
        115                 120                 125             


Asp Tyr Ser Arg Arg Arg Gly Gly Pro Pro Arg Arg Gly Arg Gly Ala 
    130                 135                 140                 


Ser Arg Gly Arg Glu Phe Arg Gly Gln Glu Asn Gly Leu Asp Gly Thr 
145                 150                 155                 160 


Lys Ser Gly Gly Pro Ser Gly Arg Gly Thr Glu Arg Gly Arg Arg Gly 
                165                 170                 175     


Arg Gly Arg Gly Arg Gly Gly Ser Gly Arg Arg Gly Gly Arg Phe Ser 
            180                 185                 190         


Ala Gln Gly Met Gly Thr Phe Asn Pro Ala Asp Tyr Ala Glu Pro Ala 
        195                 200                 205             


Asn Thr Asp Asp Asn Tyr Gly Asn Ser Ser Gly Asn Thr Trp Asn Asn 
    210                 215                 220                 


Thr Gly His Phe Glu Pro Asp Asp Gly Thr Ser Glu 
225                 230                 235     

<210>  1128
<211>  1731
<212>  DNA
<213>  Homo sapiens

<400>  1128
agcctgagag gggagagcga gaaagagcgc gagcgagcga ggcctgggcc ttgcctgagt     60

attctacctt gtaaatactg ttatttgtat atactgtaaa tgatgacatc ggtgggcact    120

aaccgagccc ggggaaactg ggaacaacct caaaaccaaa accagacaca gcacaagcag    180

cggccacagg ccactgcaga acaaattaga cttgcacaga tgatttcgga ccataatgat    240

gctgactttg aggagaaggt gaaacaattg attgatatta caggcaagaa ccaggatgaa    300

tgtgtgattg ctttgcatga ctgcaatgga gatgtcaaca gagctatcaa tgttcttctg    360

gaaggaaacc cagacacgca ttcctgggag atggtcggga agaagaaggg agtctcaggc    420

cagaaggatg gtggccagac acgggggaga ggtgccagcc gtggacgaga gtttcgaggt    480

caggaaaatg gattggatgg caccaagagt ggagggcctt ctggaagagg aacagaaaga    540

ggcagaaggg gccgtggccg aggcagaggt ggctctggta ggcgaggagg aaggttttct    600

gctcaaggaa tgggaacctt taacccagct gattatgcag agccagccaa tactgatgat    660

aactatggca atagcagcgt gtctcctcca gtctcaatag tggcagtagc ctgggcctca    720

gcctaggcag caactccact gtcacagcct cgactcgaag ctcagttgct acgacttcag    780

gaaaagctcc tcccaacctc cctcctgggg tcccgccgtt gttgcctaat ccgtatatta    840

tggctccagg gctgttacat gcctacccgc cacaagtata tggttatgat gacttgcaga    900

tgcttcagac aagatttcca ttggattact acagcatccc atttcccaca cccactactc    960

cgctgactgg gagggatggt agcctggcca gcaaccctta ttctggtgac ctcacaaagt   1020

tcggccgtgg ggatgcctcc tccccagccc cggccacaac cttggcccaa ccccaacaga   1080

accagacgca gactcaccat accacgcagc agacattcct gaacccggcg ctgcctcctg   1140

gctacagtta caccagcctg ccatactata caggggtccc gggcctcccc agcaccttcc   1200

agtatgggcc tgctgtgttc cctgtggctc ctacctcttc caagcagcat ggtgtgaatg   1260

tcagtgtgaa tgcatcggcc acccctttcc aacagccgag tggatatggg tctcatggat   1320

acaacactgg aagaaaatat ccaccccctt acaagcattt ctggacggct gagagctaat   1380

ttggcccaag gctgggggct gtgttttgtg tgtgtgtata aatttgcact gaagtcttgt   1440

ttcagaaacc agaccactga ggagagcctg ctgagctgag gccatggcct gcgtggcttg   1500

gggaaatgag ttggtggata ccttctgggc ttttgaactt gcccctcccc catttccctc   1560

tcccccatgt gtctgaccct gtcttaccca tttcaagttc aagcggtgca gcaccttcga   1620

agcatcaatg cacacacctg ctgttgcttt tgatttctgg aaggcatgta gtttcaactt   1680

gtaacaaaaa tatttgtagt cttcaataaa ctgtggtatt tctttagcta a            1731


<210>  1129
<211>  208
<212>  PRT
<213>  Homo sapiens

<400>  1129


Met Met Thr Ser Val Gly Thr Asn Arg Ala Arg Gly Asn Trp Glu Gln 
1               5                   10                  15      


Pro Gln Asn Gln Asn Gln Thr Gln His Lys Gln Arg Pro Gln Ala Thr 
            20                  25                  30          


Ala Glu Gln Ile Arg Leu Ala Gln Met Ile Ser Asp His Asn Asp Ala 
        35                  40                  45              


Asp Phe Glu Glu Lys Val Lys Gln Leu Ile Asp Ile Thr Gly Lys Asn 
    50                  55                  60                  


Gln Asp Glu Cys Val Ile Ala Leu His Asp Cys Asn Gly Asp Val Asn 
65                  70                  75                  80  


Arg Ala Ile Asn Val Leu Leu Glu Gly Asn Pro Asp Thr His Ser Trp 
                85                  90                  95      


Glu Met Val Gly Lys Lys Lys Gly Val Ser Gly Gln Lys Asp Gly Gly 
            100                 105                 110         


Gln Thr Arg Gly Arg Gly Ala Ser Arg Gly Arg Glu Phe Arg Gly Gln 
        115                 120                 125             


Glu Asn Gly Leu Asp Gly Thr Lys Ser Gly Gly Pro Ser Gly Arg Gly 
    130                 135                 140                 


Thr Glu Arg Gly Arg Arg Gly Arg Gly Arg Gly Arg Gly Gly Ser Gly 
145                 150                 155                 160 


Arg Arg Gly Gly Arg Phe Ser Ala Gln Gly Met Gly Thr Phe Asn Pro 
                165                 170                 175     


Ala Asp Tyr Ala Glu Pro Ala Asn Thr Asp Asp Asn Tyr Gly Asn Ser 
            180                 185                 190         


Ser Val Ser Pro Pro Val Ser Ile Val Ala Val Ala Trp Ala Ser Ala 
        195                 200                 205             

<210>  1130
<211>  488
<212>  DNA
<213>  Homo sapiens

<400>  1130
agtattctac cttgtaaata ctgttatttg tatatactgt aaatgatgac atcggtgggc     60

actaaccgag cccggggaaa ctgggaacaa cctcaaaacc aaaaccagac acagcacaag    120

cagcggccac aggccactgc agaacaaatt agacttgcac agatgatttc ggaccataat    180

gatgctgact ttgaggagaa ggtgaaacaa ttgattgata ttacaggcaa gaaccaggat    240

gaatgtgtga ttgctttgca tgactgcaat ggagatgtca acagagctat caatgttctt    300

ctggaaggaa acccagacac gcattcctgg gagatggtcg ggaagaagaa gggagtctca    360

ggccagaagg atggtggcca gacggaatcc aatgaggaag gcaaagaaaa tcgagaccgg    420

gacagagact atagtcggcg acgtggtggg ccaccaagac gggggagagg tgccagccgt    480

ggacgaga                                                             488


<210>  1131
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  1131


Met Met Thr Ser Val Gly Thr Asn Arg Ala Arg Gly Asn Trp Glu Gln 
1               5                   10                  15      


Pro Gln Asn Gln Asn Gln Thr Gln His Lys Gln Arg Pro Gln Ala Thr 
            20                  25                  30          


Ala Glu Gln Ile Arg Leu Ala Gln Met Ile Ser Asp His Asn Asp Ala 
        35                  40                  45              


Asp Phe Glu Glu Lys Val Lys Gln Leu Ile Asp Ile Thr Gly Lys Asn 
    50                  55                  60                  


Gln Asp Glu Cys Val Ile Ala Leu His Asp Cys Asn Gly Asp Val Asn 
65                  70                  75                  80  


Arg Ala Ile Asn Val Leu Leu Glu Gly Asn Pro Asp Thr His Ser Trp 
                85                  90                  95      


Glu Met Val Gly Lys Lys Lys Gly Val Ser Gly Gln Lys Asp Gly Gly 
            100                 105                 110         


Gln Thr Glu Ser Asn Glu Glu Gly Lys Glu Asn Arg Asp Arg Asp Arg 
        115                 120                 125             


Asp Tyr Ser Arg Arg Arg Gly Gly Pro Pro Arg Arg Gly Arg Gly Ala 
    130                 135                 140                 


Ser Arg Gly 
145         

<210>  1132
<211>  316
<212>  DNA
<213>  Homo sapiens

<400>  1132
agtattctac cttgtaaata ctgttatttg tatatactgt aaatgatgac atcggtgggc     60

actaaccgag cccggggaaa ctgggaacaa cctcaaaacc aaaaccagac acagcacaag    120

cagcggccac aggccactgc agaacaaatt agacttgcac agatgatttc ggaccataat    180

gatgctgact ttgaggagaa ggtgaaacaa ttgattgata ttacaggcaa atccacatcg    240

gctccacaga tgtcgcctgg atcttcagac aaccagtcct ctagccctca gccggctcag    300

cagaaactga aacagc                                                    316


<210>  1133
<211>  90
<212>  PRT
<213>  Homo sapiens

<400>  1133


Met Met Thr Ser Val Gly Thr Asn Arg Ala Arg Gly Asn Trp Glu Gln 
1               5                   10                  15      


Pro Gln Asn Gln Asn Gln Thr Gln His Lys Gln Arg Pro Gln Ala Thr 
            20                  25                  30          


Ala Glu Gln Ile Arg Leu Ala Gln Met Ile Ser Asp His Asn Asp Ala 
        35                  40                  45              


Asp Phe Glu Glu Lys Val Lys Gln Leu Ile Asp Ile Thr Gly Lys Ser 
    50                  55                  60                  


Thr Ser Ala Pro Gln Met Ser Pro Gly Ser Ser Asp Asn Gln Ser Ser 
65                  70                  75                  80  


Ser Pro Gln Pro Ala Gln Gln Lys Leu Lys 
                85                  90  

<210>  1134
<211>  491
<212>  DNA
<213>  Homo sapiens

<400>  1134
agtattctac cttgtaaata ctgttatttg tatatactgt aaatgatgac atcggtgggc     60

actaaccgag cccggggaaa ctgggaacaa cctcaaaacc aaaaccagac acagcacaag    120

cagcggccac aggccactgc agaacaaatt agacttgcac agtatatggt tatgatgact    180

tgcagatgct tcagacaaga tttccattgg attactacag catcccattt cccacaccca    240

ctactccgct gactgggagg gatggtagcc tggccagcaa cccttattct ggtgacctca    300

caaagttcgg ccgtggggat gcctcctccc cagccccggc cacaaccttg gcccaacccc    360

aacagaacca gacgcagact caccatacca cgcagcagac attcctgaac ccggcgctgc    420

ctcctggcta cagttacacc agcctgccat actatacagg ggtcccgggc ctccccagca    480

ccttccagta t                                                         491


<210>  1135
<211>  101
<212>  PRT
<213>  Homo sapiens

<400>  1135


Met Leu Gln Thr Arg Phe Pro Leu Asp Tyr Tyr Ser Ile Pro Phe Pro 
1               5                   10                  15      


Thr Pro Thr Thr Pro Leu Thr Gly Arg Asp Gly Ser Leu Ala Ser Asn 
            20                  25                  30          


Pro Tyr Ser Gly Asp Leu Thr Lys Phe Gly Arg Gly Asp Ala Ser Ser 
        35                  40                  45              


Pro Ala Pro Ala Thr Thr Leu Ala Gln Pro Gln Gln Asn Gln Thr Gln 
    50                  55                  60                  


Thr His His Thr Thr Gln Gln Thr Phe Leu Asn Pro Ala Leu Pro Pro 
65                  70                  75                  80  


Gly Tyr Ser Tyr Thr Ser Leu Pro Tyr Tyr Thr Gly Val Pro Gly Leu 
                85                  90                  95      


Pro Ser Thr Phe Gln 
            100     

<210>  1136
<211>  444
<212>  DNA
<213>  Homo sapiens

<400>  1136
agtattctac cttgtaaata ctgttatttg tatatactgt aaatgatgac atcggtgggc     60

actaaccgag cccggggaaa ctgggaacaa cctcaaaacc aaaaccagac acagcacaag    120

cagcggccac aggccactgc agaacaaatt agacttgcac agatgatttc ggaccataat    180

gatgtgagct gaggccatgg cctgcgtggc ttggggaaat gagttggtgg ataccttctg    240

ggcttttgaa cttgcccctc ccccatttcc ctctccccca tgtgtctgac cctgtcttac    300

ccatttcaag ttcaagcggt gcagcacctt cgaagcatca atgcacacac ctgctgttgc    360

ttttgatttc tggaaggcat gtagtttcaa cttgtaacaa aaatatttgt agtcttcaat    420

aaactgtggt atttctttag ctaa                                           444


<210>  1137
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  1137


Met Met Thr Ser Val Gly Thr Asn Arg Ala Arg Gly Asn Trp Glu Gln 
1               5                   10                  15      


Pro Gln Asn Gln Asn Gln Thr Gln His Lys Gln Arg Pro Gln Ala Thr 
            20                  25                  30          


Ala Glu Gln Ile Arg Leu Ala Gln Met Ile Ser Asp His Asn Asp Val 
        35                  40                  45              


Ser 
    

<210>  1138
<211>  1066
<212>  DNA
<213>  Homo sapiens

<400>  1138
cccccagtgg tcagtgtctc ctccagtctc aatagtggca gtagcctggg cctcagccta     60

ggcagcaact ccactgtcac agcctcgact cgaagctcag ttgctacgac ttcaggaaaa    120

gctcctccca acctccctcc tggggtcccg ccgttgttgc ctaatccgta tattatggct    180

ccagggctgt tacatgccta cccgccacaa gtatatggtt atgatgactt gcagatgctt    240

cagacaagat ttccattgga ttactacagc atcccatttc ccacacccac tactccgctg    300

actgggaggg atggtagcct ggccagcaac ccttattctg gtgacctcac aaagttcggc    360

cgtggggatg cctcctcccc agccccggcc acaaccttgg cccaacccca acagaaccag    420

acgcagactc accataccac gcagcagaca ttcctgaacc cggcgctgcc tcctggctac    480

agttacacca gcctgccata ctatacaggg gtcccgggcc tccccagcac cttccagtat    540

gggcctgctg tgttccctgt ggctcctacc tcttccaagc agcatggtgt gaatgtcagt    600

gtgaatgcat cggccacccc tttccaacag ccgagtggat atgggtctca tggatacaac    660

actggaagaa aatatccacc cccttacaag catttctgga cggctgagag ctaatttggc    720

ccaaggctgg gggctgtgtt ttgtgtgtgt gtataaattt gcactgaagt cttgtttcag    780

aaaccagacc actgaggaga gcctgctgag ctgaggccat ggcctgcgtg gcttggggaa    840

atgagttggt ggataccttc tgggcttttg aacttgcccc tcccccattt ccctctcccc    900

catgtgtctg accctgtctt acccatttca agttcaagcg gtgcagcacc ttcgaagcat    960

caatgcacac acctgctgtt gcttttgatt tctggaaggc atgtagtttc aacttgtaac   1020

aaaaatattt gtagtcttca ataaactgtg gtatttcttt agctaa                  1066


<210>  1139
<211>  179
<212>  PRT
<213>  Homo sapiens

<400>  1139


Met Ala Pro Gly Leu Leu His Ala Tyr Pro Pro Gln Val Tyr Gly Tyr 
1               5                   10                  15      


Asp Asp Leu Gln Met Leu Gln Thr Arg Phe Pro Leu Asp Tyr Tyr Ser 
            20                  25                  30          


Ile Pro Phe Pro Thr Pro Thr Thr Pro Leu Thr Gly Arg Asp Gly Ser 
        35                  40                  45              


Leu Ala Ser Asn Pro Tyr Ser Gly Asp Leu Thr Lys Phe Gly Arg Gly 
    50                  55                  60                  


Asp Ala Ser Ser Pro Ala Pro Ala Thr Thr Leu Ala Gln Pro Gln Gln 
65                  70                  75                  80  


Asn Gln Thr Gln Thr His His Thr Thr Gln Gln Thr Phe Leu Asn Pro 
                85                  90                  95      


Ala Leu Pro Pro Gly Tyr Ser Tyr Thr Ser Leu Pro Tyr Tyr Thr Gly 
            100                 105                 110         


Val Pro Gly Leu Pro Ser Thr Phe Gln Tyr Gly Pro Ala Val Phe Pro 
        115                 120                 125             


Val Ala Pro Thr Ser Ser Lys Gln His Gly Val Asn Val Ser Val Asn 
    130                 135                 140                 


Ala Ser Ala Thr Pro Phe Gln Gln Pro Ser Gly Tyr Gly Ser His Gly 
145                 150                 155                 160 


Tyr Asn Thr Gly Arg Lys Tyr Pro Pro Pro Tyr Lys His Phe Trp Thr 
                165                 170                 175     


Ala Glu Ser 
            

<210>  1140
<211>  1619
<212>  DNA
<213>  Homo sapiens

<400>  1140
gtctcctcca gtctcaatag tggcagtagc ctgggcctca gcctaggcag caactccact     60

gtcacagcct cgactcgaag ctcagttgct acgacttcag gaaaagctcc tcccaacctc    120

cctcctgggg tcccgccgtt gttgcctaat ccgtatatta tggctccagg gctgttacat    180

gcctacccgc cacaagtata tggttatgat gacttgcaga tgcttcagac aagatttcca    240

ttggattact acagcatccc atttcccaca cccactactc cgctgactgg gagggatggt    300

agcctggcca gcaaccctta ttctggtgac ctcacaaagt tcggccgtgg ggatgcctcc    360

tccccagccc cggccacaac cttggcccaa ccccaacaga accagacgca gactcaccat    420

accacgcagc agacattcct gaacccggcg ctgcctcctg gctacagtta caccagcctg    480

ccatactata caggggtccc gggcctcccc agcaccttcc agtatgggcc tgctgtgttc    540

cctgtggctc ctacctcttc caagcagcat ggtgtgaatg tcagtgtgaa tgcatcggcc    600

acccctttcc aacagccgag tggatatggg tctcatggat acaacactgg tgtttcagtc    660

acctccagta acacgggcgt gccagatatc tcgggttctg tgtactccaa aacccagcag    720

tcctttgaga aacaaggttt tcattccggt actcctgctg cttccttcaa cttgccttca    780

gccctaggaa gtgggggccc catcaatccg gccacagctg ctgcctaccc acctgccccc    840

tttatgcaca ttctgacccc ccatcagcag ccgcattctc agatccttca ccatcacctg    900

cagcaggatg gccagctacc atatttgcag atgattctct gttgccagcg ccagcaggag    960

gagcagacgg gcagcgggca acgtagccag accagctcca tcccgcagaa gccccagacc   1020

aacaagtctg cctacaacag ctacagctgg ggggccaact gaggccctga ccctcttctc   1080

ccggtcccat cttctgagag ggcttctcag cctggaaact atggaaacag catcaaagag   1140

aaaggaatgt ggggggtttc cgctgccccc cacccccagc ggcccacccc atgcctcagc   1200

ttcatgtctg tcccattcct ataccatccc caccctgttg tatgtattat aggatttgta   1260

ttttctcctt ttttttcccc cttccattcc ttctcccctc ttgcattcaa gattatgaaa   1320

ctttgctatg ggccctgcac ttcctttgct tcctcctgtt caccctggtg gtgtacggat   1380

gaggcgggga ggtgggaccc ccaaacatat atcagcccaa cagccctaag tctccttctt   1440

tattattagg aaaacaacaa caacaacaaa caaaaaaatg gcgtcatgaa tatgaacagc   1500

attgtcagat gaattagttg aagtggtttt ttttttgttt tttttttttt tttgtactgt   1560

gtcctcaaat ttaatggatt aatgtgtctt gtatatataa aaagaaaacc tctaccttc    1619


<210>  1141
<211>  300
<212>  PRT
<213>  Homo sapiens

<400>  1141


Met Ala Pro Gly Leu Leu His Ala Tyr Pro Pro Gln Val Tyr Gly Tyr 
1               5                   10                  15      


Asp Asp Leu Gln Met Leu Gln Thr Arg Phe Pro Leu Asp Tyr Tyr Ser 
            20                  25                  30          


Ile Pro Phe Pro Thr Pro Thr Thr Pro Leu Thr Gly Arg Asp Gly Ser 
        35                  40                  45              


Leu Ala Ser Asn Pro Tyr Ser Gly Asp Leu Thr Lys Phe Gly Arg Gly 
    50                  55                  60                  


Asp Ala Ser Ser Pro Ala Pro Ala Thr Thr Leu Ala Gln Pro Gln Gln 
65                  70                  75                  80  


Asn Gln Thr Gln Thr His His Thr Thr Gln Gln Thr Phe Leu Asn Pro 
                85                  90                  95      


Ala Leu Pro Pro Gly Tyr Ser Tyr Thr Ser Leu Pro Tyr Tyr Thr Gly 
            100                 105                 110         


Val Pro Gly Leu Pro Ser Thr Phe Gln Tyr Gly Pro Ala Val Phe Pro 
        115                 120                 125             


Val Ala Pro Thr Ser Ser Lys Gln His Gly Val Asn Val Ser Val Asn 
    130                 135                 140                 


Ala Ser Ala Thr Pro Phe Gln Gln Pro Ser Gly Tyr Gly Ser His Gly 
145                 150                 155                 160 


Tyr Asn Thr Gly Val Ser Val Thr Ser Ser Asn Thr Gly Val Pro Asp 
                165                 170                 175     


Ile Ser Gly Ser Val Tyr Ser Lys Thr Gln Gln Ser Phe Glu Lys Gln 
            180                 185                 190         


Gly Phe His Ser Gly Thr Pro Ala Ala Ser Phe Asn Leu Pro Ser Ala 
        195                 200                 205             


Leu Gly Ser Gly Gly Pro Ile Asn Pro Ala Thr Ala Ala Ala Tyr Pro 
    210                 215                 220                 


Pro Ala Pro Phe Met His Ile Leu Thr Pro His Gln Gln Pro His Ser 
225                 230                 235                 240 


Gln Ile Leu His His His Leu Gln Gln Asp Gly Gln Leu Pro Tyr Leu 
                245                 250                 255     


Gln Met Ile Leu Cys Cys Gln Arg Gln Gln Glu Glu Gln Thr Gly Ser 
            260                 265                 270         


Gly Gln Arg Ser Gln Thr Ser Ser Ile Pro Gln Lys Pro Gln Thr Asn 
        275                 280                 285             


Lys Ser Ala Tyr Asn Ser Tyr Ser Trp Gly Ala Asn 
    290                 295                 300 

<210>  1142
<211>  2276
<212>  DNA
<213>  Homo sapiens

<400>  1142
gtctcctcca gtctcaatag tggcagtagc ctgggcctca gcctaggcag caactccact     60

gtcacagcct cgactcgaag ctcagttgct acgacttcag gaaaagctcc tcccaacctc    120

cctcctgggg tcccgccgtt gttgcctaat ccgtatatta tggctccagg gctgttacat    180

gcctacccgc cacaagtata tggttatgat gacttgcaga tgcttcagac aagatttcca    240

ttggattact acagcatccc atttcccaca cccactactc cgctgactgg gagggatggt    300

agcctggcca gcaaccctta ttctggtgac ctcacaaagt tcggccgtgg ggatgcctcc    360

tccccagccc cggccacaac cttggcccaa ccccaacaga accagacgca gactcaccat    420

accacgcagc agacattcct gaacccggcg ctgcctcctg gctacagtta caccagcctg    480

ccatactata caggggtccc gggcctcccc agcaccttcc agtatgggcc tgctgtgttc    540

cctgtggctc ctacctcttc caagcagcat ggtgtgaatg tcagtgtgaa tgcatcggcc    600

acccctttcc aacagccgag tggatatggg tctcatggat acaacactgg tgtttcagtc    660

acctccagta acacgggcgt gccagatatc tcgggttctg tgtactccaa aacccagcag    720

tcctttgaga aacaaggttt tcattccggt actcctgctg cttccttcaa cttgccttca    780

gccctaggaa gtgggggccc catcaatccg gccacagctg ctgcctaccc acctgccccc    840

tttatgcaca ttctgacccc ccatcagcag ccgcattctc agatccttca ccatcacctg    900

cagcaggatg gccagctacc atatttgcag atgattctct gttgccagcg ccagcaggag    960

gagcagacgg gcagcgggca acgtagccag accagctcca tcccgcagaa gccccagacc   1020

aacaagtctg cctacaacag ctacagctgg ggggccaact gaggccctga ccctcttctc   1080

ccggtcccat cttctgagag ggcttctcag cctggaaact atggaaacag catcaaagag   1140

aaaggaatgt ggggggtttc cgctgccccc cacccccagc ggcccacccc atgcctcagc   1200

ttcatgtctg tcccattcct ataccatccc caccctgttg tatgtattat aggatttgta   1260

ttttctcctt ttttttcccc cttccattcc ttctcccctc ttgcattcaa gattatgaaa   1320

ctttgctatg ggccctgcac ttcctttgct tcctcctgtt caccctggtg gtgtacggat   1380

gaggcgggga ggtgggaccc ccaaacatat atcagcccaa cagccctaag tctccttctt   1440

tattattagg aaaacaacaa caacaacaaa caaaaaaatg gcgtcatgaa tatgaacagc   1500

attgtcagat gaattagttg aagtggtttt ttttttgttt tttttttttt tttgtactgt   1560

gtcctcaaat ttaatggatt aatgtgtctt gtatatataa aaagaaaacc tctaccttca   1620

gcctctgcct attcttgctc cgtctaggac atcctcaatt tcgtcgatga ccagcttggt   1680

gaataagtat tactgtacca actgggcctc ctctagcagg cccctgaagg cagtggaata   1740

aaatgaaatc ttcgcccttt aagaactcct gaccttaatg tggtagtagt atcttgtcct   1800

tgaggggatt tccttcccct cacccctaag actttcacaa cctggtgact ggaaagaacc   1860

accacaaatc ttcatttcct ccagaaactg ctacatctac agccgatttc aggcagtaaa   1920

gggagaggga tagaggagat tgggtggaaa atggagagga tcaagaagga gctgagacca   1980

tttcaaagaa aaaaaatgct ttatagagtt ttaagtatga cttagatggg tccaggcaaa   2040

taaactaaaa agaagtgaag gcaacatgta tcgtctggca gaactaaatc ttggagtggg   2100

gtgagggatg aaagactaca tattgggtac agtgtacact gctcgggtga tgggtgcgct   2160

aaagtcgcag aaatcactaa agaactcatc catgtaacca aacaccacct gtaccccaaa   2220

aacgaaataa aaaaacaaaa ccttggggcc cattccccct aggaatggac tactgt       2276


<210>  1143
<211>  300
<212>  PRT
<213>  Homo sapiens

<400>  1143


Met Ala Pro Gly Leu Leu His Ala Tyr Pro Pro Gln Val Tyr Gly Tyr 
1               5                   10                  15      


Asp Asp Leu Gln Met Leu Gln Thr Arg Phe Pro Leu Asp Tyr Tyr Ser 
            20                  25                  30          


Ile Pro Phe Pro Thr Pro Thr Thr Pro Leu Thr Gly Arg Asp Gly Ser 
        35                  40                  45              


Leu Ala Ser Asn Pro Tyr Ser Gly Asp Leu Thr Lys Phe Gly Arg Gly 
    50                  55                  60                  


Asp Ala Ser Ser Pro Ala Pro Ala Thr Thr Leu Ala Gln Pro Gln Gln 
65                  70                  75                  80  


Asn Gln Thr Gln Thr His His Thr Thr Gln Gln Thr Phe Leu Asn Pro 
                85                  90                  95      


Ala Leu Pro Pro Gly Tyr Ser Tyr Thr Ser Leu Pro Tyr Tyr Thr Gly 
            100                 105                 110         


Val Pro Gly Leu Pro Ser Thr Phe Gln Tyr Gly Pro Ala Val Phe Pro 
        115                 120                 125             


Val Ala Pro Thr Ser Ser Lys Gln His Gly Val Asn Val Ser Val Asn 
    130                 135                 140                 


Ala Ser Ala Thr Pro Phe Gln Gln Pro Ser Gly Tyr Gly Ser His Gly 
145                 150                 155                 160 


Tyr Asn Thr Gly Val Ser Val Thr Ser Ser Asn Thr Gly Val Pro Asp 
                165                 170                 175     


Ile Ser Gly Ser Val Tyr Ser Lys Thr Gln Gln Ser Phe Glu Lys Gln 
            180                 185                 190         


Gly Phe His Ser Gly Thr Pro Ala Ala Ser Phe Asn Leu Pro Ser Ala 
        195                 200                 205             


Leu Gly Ser Gly Gly Pro Ile Asn Pro Ala Thr Ala Ala Ala Tyr Pro 
    210                 215                 220                 


Pro Ala Pro Phe Met His Ile Leu Thr Pro His Gln Gln Pro His Ser 
225                 230                 235                 240 


Gln Ile Leu His His His Leu Gln Gln Asp Gly Gln Leu Pro Tyr Leu 
                245                 250                 255     


Gln Met Ile Leu Cys Cys Gln Arg Gln Gln Glu Glu Gln Thr Gly Ser 
            260                 265                 270         


Gly Gln Arg Ser Gln Thr Ser Ser Ile Pro Gln Lys Pro Gln Thr Asn 
        275                 280                 285             


Lys Ser Ala Tyr Asn Ser Tyr Ser Trp Gly Ala Asn 
    290                 295                 300 

<210>  1144
<211>  601
<212>  DNA
<213>  Homo sapiens

<400>  1144
ctgggcctca gcctaggcag caactccact gtcacagcct cgactcgaag ctcagttgct     60

acgacttcag gaaaagctcc tcccaacctc cctcctgggg tcccgccgtt gttgcctaat    120

ccgtatatta tggctccagg gctgttacat gcctacccgc cacaagtata tggttatgat    180

gacttgcaga tgcttcagac aagatttcca ttggattact acagcatccc atttcccaca    240

cccactactc cgctgactgg gagggatggt agcctggcca gcaaccctta ttctggtgac    300

ctcacaaagt tcggccgtgg ggatgcctcc tccccagccc cggccacaac cttggcccaa    360

ccccaacaga accagacgca gactcaccat accacgcagc agacattcct gaacccggcg    420

ctgcctcctg gctacagtta caccagcctg ccatactata caggggtccc gggcctcccc    480

acaccttcga agcatcaatg cacacacctg ctgttgcttt tgatttctgg aaggcatgta    540

gtttcaactt gtaacaaaaa tatttgtagt cttcaataaa ctgtggtatt tctttagcta    600

a                                                                    601


<210>  1145
<211>  149
<212>  PRT
<213>  Homo sapiens

<400>  1145


Met Ala Pro Gly Leu Leu His Ala Tyr Pro Pro Gln Val Tyr Gly Tyr 
1               5                   10                  15      


Asp Asp Leu Gln Met Leu Gln Thr Arg Phe Pro Leu Asp Tyr Tyr Ser 
            20                  25                  30          


Ile Pro Phe Pro Thr Pro Thr Thr Pro Leu Thr Gly Arg Asp Gly Ser 
        35                  40                  45              


Leu Ala Ser Asn Pro Tyr Ser Gly Asp Leu Thr Lys Phe Gly Arg Gly 
    50                  55                  60                  


Asp Ala Ser Ser Pro Ala Pro Ala Thr Thr Leu Ala Gln Pro Gln Gln 
65                  70                  75                  80  


Asn Gln Thr Gln Thr His His Thr Thr Gln Gln Thr Phe Leu Asn Pro 
                85                  90                  95      


Ala Leu Pro Pro Gly Tyr Ser Tyr Thr Ser Leu Pro Tyr Tyr Thr Gly 
            100                 105                 110         


Val Pro Gly Leu Pro Thr Pro Ser Lys His Gln Cys Thr His Leu Leu 
        115                 120                 125             


Leu Leu Leu Ile Ser Gly Arg His Val Val Ser Thr Cys Asn Lys Asn 
    130                 135                 140                 


Ile Cys Ser Leu Gln 
145                 

<210>  1146
<211>  963
<212>  DNA
<213>  Homo sapiens

<400>  1146
ctgggcctca gcctaggcag caactccact gtcacagcct cgactcgaag ctcagttgct     60

acgacttcag gaaaagctcc tcccaacctc cctcctgggg tcccgccgtt gttgcctaat    120

ccgtatatta tggctccagg gctgttacat gcctacccgc cacaagtata tggttatgat    180

gacttgcaga tgcttcagac aagatttcca ttggattact acagcatccc atttcccaca    240

cccactactc cgctgactgg gagggatggt agcctggcca gcaaccctta ttctggccca    300

accccaacag aaccagacgc agactcacca taccacgcag cagacattcc tgaacccggc    360

gctgcctcct ggctacagtt acaccagcct gccatactat acaggggtcc cgggcctccc    420

cagcaccttc cagtatgggc ctgctgtgtt ccctgtggct cctacctctt ccaagcagca    480

tggtgtgaat gtcagtgtga atgcatcggc cacccctttc caacagccga gtggatatgg    540

gtctcatgga tacaacactg gaagaaaata tccaccccct tacaagcatt tctggacggc    600

tgagagctaa tttggcccaa ggctgggggc tgtgttttgt gtgtgtgtat aaatttgcac    660

tgaagtcttg tttcagaaac cagaccactg aggagagcct gctgagctga ggccatggcc    720

tgcgtggctt ggggaaatga gttggtggat accttctggg cttttgaact tgcccctccc    780

ccatttccct ctcccccatg tgtctgaccc tgtcttaccc atttcaagtt caagcggtgc    840

agcaccttcg aagcatcaat gcacacacct gctgttgctt ttgatttctg gaaggcatgt    900

agtttcaact tgtaacaaaa atatttgtag tcttcaataa actgtggtat ttctttagct    960

aac                                                                  963


<210>  1147
<211>  157
<212>  PRT
<213>  Homo sapiens

<400>  1147


Met Ala Pro Gly Leu Leu His Ala Tyr Pro Pro Gln Val Tyr Gly Tyr 
1               5                   10                  15      


Asp Asp Leu Gln Met Leu Gln Thr Arg Phe Pro Leu Asp Tyr Tyr Ser 
            20                  25                  30          


Ile Pro Phe Pro Thr Pro Thr Thr Pro Leu Thr Gly Arg Asp Gly Ser 
        35                  40                  45              


Leu Ala Ser Asn Pro Tyr Ser Gly Pro Thr Pro Thr Glu Pro Asp Ala 
    50                  55                  60                  


Asp Ser Pro Tyr His Ala Ala Asp Ile Pro Glu Pro Gly Ala Ala Ser 
65                  70                  75                  80  


Trp Leu Gln Leu His Gln Pro Ala Ile Leu Tyr Arg Gly Pro Gly Pro 
                85                  90                  95      


Pro Gln His Leu Pro Val Trp Ala Cys Cys Val Pro Cys Gly Ser Tyr 
            100                 105                 110         


Leu Phe Gln Ala Ala Trp Cys Glu Cys Gln Cys Glu Cys Ile Gly His 
        115                 120                 125             


Pro Phe Pro Thr Ala Glu Trp Ile Trp Val Ser Trp Ile Gln His Trp 
    130                 135                 140                 


Lys Lys Ile Ser Thr Pro Leu Gln Ala Phe Leu Asp Gly 
145                 150                 155         

<210>  1148
<211>  680
<212>  DNA
<213>  Homo sapiens

<400>  1148
tttttaagcc agattttgaa gagtataaga gacagagact tgtagaatag agagtaaaac     60

tggttgttcg tgtatgtttt gtgtctactc tattggtatc aagaagccag cctactagaa    120

tcagtagtat ttagctcaag gaaagcttca agacctttca tgaatcattt aatctctgtg    180

tactttactg ctttttcctt aaataaaatt gaaggaaata atccgtgtcc tgttctaacc    240

cagaatgagg atgaatgttc tgttgaatta gcttgtctct tggctccttg ttttgctaac    300

atcatgacca gttcctgtta ttgctatatg tctgtatctt tcagccacaa gtatatggtt    360

atgatgactt gcagatgctt cagacaagat ttccattgga ttactacagc atcccatttc    420

ccacacccac tactccgctg actgggaggg atggtagcct ggccagcaac ccttattctg    480

gtgacctcac aaagttcggc cgtggggatg cctcctcccc agccccggcc acaaccttgg    540

cccaacccca acagaaccag acgcagactc accataccac gcagcagaca ttcctgaacc    600

cggcgctgcc tcctggctac agttacacca gcctgccata ctatacaggg gtcccgggcc    660

tccccagcac cttccagtat                                                680


<210>  1149
<211>  101
<212>  PRT
<213>  Homo sapiens

<400>  1149


Met Leu Gln Thr Arg Phe Pro Leu Asp Tyr Tyr Ser Ile Pro Phe Pro 
1               5                   10                  15      


Thr Pro Thr Thr Pro Leu Thr Gly Arg Asp Gly Ser Leu Ala Ser Asn 
            20                  25                  30          


Pro Tyr Ser Gly Asp Leu Thr Lys Phe Gly Arg Gly Asp Ala Ser Ser 
        35                  40                  45              


Pro Ala Pro Ala Thr Thr Leu Ala Gln Pro Gln Gln Asn Gln Thr Gln 
    50                  55                  60                  


Thr His His Thr Thr Gln Gln Thr Phe Leu Asn Pro Ala Leu Pro Pro 
65                  70                  75                  80  


Gly Tyr Ser Tyr Thr Ser Leu Pro Tyr Tyr Thr Gly Val Pro Gly Leu 
                85                  90                  95      


Pro Ser Thr Phe Gln 
            100     

<210>  1150
<211>  1406
<212>  DNA
<213>  Homo sapiens

<400>  1150
ttgcagatgc ttcagacaag atttccattg gattactaca gcatcccatt tcccacaccc     60

actactccgc tgactgggag ggatggtagc ctggccagca acccttattc tggtgacctc    120

acaaagttcg gccgtgggga tgcctcctcc ccagccccgg ccacaacctt ggcccaaccc    180

caacagaacc agacgcagac tcaccatacc acgcagcaga cattcctgaa cccggcgctg    240

cctcctggct acagttacac cagcctgcca tactatacag gggtcccggg cctccccagc    300

accttccagt atgggcctgc tgtgttccct gtggctccta cctcttccaa gcagcatggt    360

gtgaatgtca gtgtgaatgc atcggccacc cctttccaac agccgagtgg atatgggtct    420

catggataca acactggtgt ttcagtcacc tccagtaaca cgggcgtgcc agatatctcg    480

ggttctgtgt actccaaaac ccagcagtcc tttgagaaac aaggttttca ttccggtact    540

cctgctgctt ccttcaactt gccttcagcc ctaggaagtg ggggccccat caatccggcc    600

acagctgctg cctacccacc tgcccccttt atgcacattc tgacccccca tcagcagccg    660

cattctcaga tccttcacca tcacctgcag caggatggcc agctaccata tttgcagatg    720

attctctgtt gccagcgcca gcaggaggag cagacgggca gcgggcaacg tagccagacc    780

agctccatcc cgcagaagcc ccagaccaac aagtctgcct acaacagcta cagctggggg    840

gccaactgag gccctgaccc tcttctcccg gtcccatctt ctgagagggc ttctcagcct    900

ggaaactatg gaaacagcat caaagagaaa ggaatgtggg gggtttccgc tgccccccac    960

ccccagcggc ccaccccatg cctcagcttc atgtctgtcc cattcctata ccatccccac   1020

cctgttgtat gtattatagg atttgtattt tctccttttt tttccccctt ccattccttc   1080

tcccctcttg cattcaagat tatgaaactt tgctatgggc cctgcacttc ctttgcttcc   1140

tcctgttcac cctggtggtg tacggatgag gcggggaggt gggaccccca aacatatatc   1200

agcccaacag ccctaagtct ccttctttat tattaggaaa acaacaacaa caacaaacaa   1260

aaaaatggcg tcatgaatat gaacagcatt gtcagatgaa ttagttgaag tggttttttt   1320

tttgtttttt tttttttttt gtactgtgtc ctcaaattta atggattaat gtgtcttgta   1380

tatataaaaa gaaaacctct accttc                                        1406


<210>  1151
<211>  280
<212>  PRT
<213>  Homo sapiens

<400>  1151


Met Leu Gln Thr Arg Phe Pro Leu Asp Tyr Tyr Ser Ile Pro Phe Pro 
1               5                   10                  15      


Thr Pro Thr Thr Pro Leu Thr Gly Arg Asp Gly Ser Leu Ala Ser Asn 
            20                  25                  30          


Pro Tyr Ser Gly Asp Leu Thr Lys Phe Gly Arg Gly Asp Ala Ser Ser 
        35                  40                  45              


Pro Ala Pro Ala Thr Thr Leu Ala Gln Pro Gln Gln Asn Gln Thr Gln 
    50                  55                  60                  


Thr His His Thr Thr Gln Gln Thr Phe Leu Asn Pro Ala Leu Pro Pro 
65                  70                  75                  80  


Gly Tyr Ser Tyr Thr Ser Leu Pro Tyr Tyr Thr Gly Val Pro Gly Leu 
                85                  90                  95      


Pro Ser Thr Phe Gln Tyr Gly Pro Ala Val Phe Pro Val Ala Pro Thr 
            100                 105                 110         


Ser Ser Lys Gln His Gly Val Asn Val Ser Val Asn Ala Ser Ala Thr 
        115                 120                 125             


Pro Phe Gln Gln Pro Ser Gly Tyr Gly Ser His Gly Tyr Asn Thr Gly 
    130                 135                 140                 


Val Ser Val Thr Ser Ser Asn Thr Gly Val Pro Asp Ile Ser Gly Ser 
145                 150                 155                 160 


Val Tyr Ser Lys Thr Gln Gln Ser Phe Glu Lys Gln Gly Phe His Ser 
                165                 170                 175     


Gly Thr Pro Ala Ala Ser Phe Asn Leu Pro Ser Ala Leu Gly Ser Gly 
            180                 185                 190         


Gly Pro Ile Asn Pro Ala Thr Ala Ala Ala Tyr Pro Pro Ala Pro Phe 
        195                 200                 205             


Met His Ile Leu Thr Pro His Gln Gln Pro His Ser Gln Ile Leu His 
    210                 215                 220                 


His His Leu Gln Gln Asp Gly Gln Leu Pro Tyr Leu Gln Met Ile Leu 
225                 230                 235                 240 


Cys Cys Gln Arg Gln Gln Glu Glu Gln Thr Gly Ser Gly Gln Arg Ser 
                245                 250                 255     


Gln Thr Ser Ser Ile Pro Gln Lys Pro Gln Thr Asn Lys Ser Ala Tyr 
            260                 265                 270         


Asn Ser Tyr Ser Trp Gly Ala Asn 
        275                 280 

<210>  1152
<211>  2063
<212>  DNA
<213>  Homo sapiens

<400>  1152
ttgcagatgc ttcagacaag atttccattg gattactaca gcatcccatt tcccacaccc     60

actactccgc tgactgggag ggatggtagc ctggccagca acccttattc tggtgacctc    120

acaaagttcg gccgtgggga tgcctcctcc ccagccccgg ccacaacctt ggcccaaccc    180

caacagaacc agacgcagac tcaccatacc acgcagcaga cattcctgaa cccggcgctg    240

cctcctggct acagttacac cagcctgcca tactatacag gggtcccggg cctccccagc    300

accttccagt atgggcctgc tgtgttccct gtggctccta cctcttccaa gcagcatggt    360

gtgaatgtca gtgtgaatgc atcggccacc cctttccaac agccgagtgg atatgggtct    420

catggataca acactggtgt ttcagtcacc tccagtaaca cgggcgtgcc agatatctcg    480

ggttctgtgt actccaaaac ccagcagtcc tttgagaaac aaggttttca ttccggtact    540

cctgctgctt ccttcaactt gccttcagcc ctaggaagtg ggggccccat caatccggcc    600

acagctgctg cctacccacc tgcccccttt atgcacattc tgacccccca tcagcagccg    660

cattctcaga tccttcacca tcacctgcag caggatggcc agctaccata tttgcagatg    720

attctctgtt gccagcgcca gcaggaggag cagacgggca gcgggcaacg tagccagacc    780

agctccatcc cgcagaagcc ccagaccaac aagtctgcct acaacagcta cagctggggg    840

gccaactgag gccctgaccc tcttctcccg gtcccatctt ctgagagggc ttctcagcct    900

ggaaactatg gaaacagcat caaagagaaa ggaatgtggg gggtttccgc tgccccccac    960

ccccagcggc ccaccccatg cctcagcttc atgtctgtcc cattcctata ccatccccac   1020

cctgttgtat gtattatagg atttgtattt tctccttttt tttccccctt ccattccttc   1080

tcccctcttg cattcaagat tatgaaactt tgctatgggc cctgcacttc ctttgcttcc   1140

tcctgttcac cctggtggtg tacggatgag gcggggaggt gggaccccca aacatatatc   1200

agcccaacag ccctaagtct ccttctttat tattaggaaa acaacaacaa caacaaacaa   1260

aaaaatggcg tcatgaatat gaacagcatt gtcagatgaa ttagttgaag tggttttttt   1320

tttgtttttt tttttttttt gtactgtgtc ctcaaattta atggattaat gtgtcttgta   1380

tatataaaaa gaaaacctct accttcagcc tctgcctatt cttgctccgt ctaggacatc   1440

ctcaatttcg tcgatgacca gcttggtgaa taagtattac tgtaccaact gggcctcctc   1500

tagcaggccc ctgaaggcag tggaataaaa tgaaatcttc gccctttaag aactcctgac   1560

cttaatgtgg tagtagtatc ttgtccttga ggggatttcc ttcccctcac ccctaagact   1620

ttcacaacct ggtgactgga aagaaccacc acaaatcttc atttcctcca gaaactgcta   1680

catctacagc cgatttcagg cagtaaaggg agagggatag aggagattgg gtggaaaatg   1740

gagaggatca agaaggagct gagaccattt caaagaaaaa aaatgcttta tagagtttta   1800

agtatgactt agatgggtcc aggcaaataa actaaaaaga agtgaaggca acatgtatcg   1860

tctggcagaa ctaaatcttg gagtggggtg agggatgaaa gactacatat tgggtacagt   1920

gtacactgct cgggtgatgg gtgcgctaaa gtcgcagaaa tcactaaaga actcatccat   1980

gtaaccaaac accacctgta ccccaaaaac gaaataaaaa aacaaaacct tggggcccat   2040

tccccctagg aatggactac tgt                                           2063


<210>  1153
<211>  280
<212>  PRT
<213>  Homo sapiens

<400>  1153


Met Leu Gln Thr Arg Phe Pro Leu Asp Tyr Tyr Ser Ile Pro Phe Pro 
1               5                   10                  15      


Thr Pro Thr Thr Pro Leu Thr Gly Arg Asp Gly Ser Leu Ala Ser Asn 
            20                  25                  30          


Pro Tyr Ser Gly Asp Leu Thr Lys Phe Gly Arg Gly Asp Ala Ser Ser 
        35                  40                  45              


Pro Ala Pro Ala Thr Thr Leu Ala Gln Pro Gln Gln Asn Gln Thr Gln 
    50                  55                  60                  


Thr His His Thr Thr Gln Gln Thr Phe Leu Asn Pro Ala Leu Pro Pro 
65                  70                  75                  80  


Gly Tyr Ser Tyr Thr Ser Leu Pro Tyr Tyr Thr Gly Val Pro Gly Leu 
                85                  90                  95      


Pro Ser Thr Phe Gln Tyr Gly Pro Ala Val Phe Pro Val Ala Pro Thr 
            100                 105                 110         


Ser Ser Lys Gln His Gly Val Asn Val Ser Val Asn Ala Ser Ala Thr 
        115                 120                 125             


Pro Phe Gln Gln Pro Ser Gly Tyr Gly Ser His Gly Tyr Asn Thr Gly 
    130                 135                 140                 


Val Ser Val Thr Ser Ser Asn Thr Gly Val Pro Asp Ile Ser Gly Ser 
145                 150                 155                 160 


Val Tyr Ser Lys Thr Gln Gln Ser Phe Glu Lys Gln Gly Phe His Ser 
                165                 170                 175     


Gly Thr Pro Ala Ala Ser Phe Asn Leu Pro Ser Ala Leu Gly Ser Gly 
            180                 185                 190         


Gly Pro Ile Asn Pro Ala Thr Ala Ala Ala Tyr Pro Pro Ala Pro Phe 
        195                 200                 205             


Met His Ile Leu Thr Pro His Gln Gln Pro His Ser Gln Ile Leu His 
    210                 215                 220                 


His His Leu Gln Gln Asp Gly Gln Leu Pro Tyr Leu Gln Met Ile Leu 
225                 230                 235                 240 


Cys Cys Gln Arg Gln Gln Glu Glu Gln Thr Gly Ser Gly Gln Arg Ser 
                245                 250                 255     


Gln Thr Ser Ser Ile Pro Gln Lys Pro Gln Thr Asn Lys Ser Ala Tyr 
            260                 265                 270         


Asn Ser Tyr Ser Trp Gly Ala Asn 
        275                 280 

<210>  1154
<211>  1020
<212>  DNA
<213>  Homo sapiens

<400>  1154
cgtagacctt gtctgactgt gctcatggcc aggcaggggg gacagtgtat gcaagagtaa     60

tgtggagttt gtgctaactc tagccagctt aattagtgac tggataaatt gcacaactct    120

cacattcttc tgttttttcc tccgtggaaa tagtactcat gctggggaat gagtgacatt    180

gaatctctgc tcttttttcc cctcttttct aggattacta cagcatccca tttcccacac    240

ccactactcc gctgactggg agggatggta gcctggccag caacccttat tctggtgacc    300

tcacaaagtt cggccgtggg gatgcctcct ccccagcccc ggccacaacc ttggcccaac    360

cccaacagaa ccagacgcag actcaccata ccacgcagca gacattcctg aacccggcgc    420

tgcctcctgg ctacagttac accagcctgc catactatac aggggtcccg ggcctcccca    480

gcaccttcca gtatgggcct gctgtgttcc ctgtggctcc tacctcttcc aagcagcatg    540

gtgtgaatgt cagtgtgaat gcatcggcca cccctttcca acagccgagt ggatatgggt    600

ctcatggata caacactgga agaaaatatc caccccctta caagcatttc tggacggctg    660

agagctaatt tggcccaagg ctgggggctg tgttttgtgt gtgtgtataa atttgcactg    720

aagtcttgtt tcagaaacca gaccactgag gagagcctgc tgagctgagg ccatggcctg    780

cgtggcttgg ggaaatgagt tggtggatac cttctgggct tttgaacttg cccctccccc    840

atttccctct cccccatgtg tctgaccctg tcttacccat ttcaagttca agcggtgcag    900

caccttcgaa gcatcaatgc acacacctgc tgttgctttt gatttctgga aggcatgtag    960

tttcaacttg taacaaaaat atttgtagtc ttcaataaac tgtggtattt ctttagctaa   1020


<210>  1155
<211>  69
<212>  PRT
<213>  Homo sapiens

<400>  1155


Met His Arg Pro Pro Leu Ser Asn Ser Arg Val Asp Met Gly Leu Met 
1               5                   10                  15      


Asp Thr Thr Leu Glu Glu Asn Ile His Pro Leu Thr Ser Ile Ser Gly 
            20                  25                  30          


Arg Leu Arg Ala Asn Leu Ala Gln Gly Trp Gly Leu Cys Phe Val Cys 
        35                  40                  45              


Val Tyr Lys Phe Ala Leu Lys Ser Cys Phe Arg Asn Gln Thr Thr Glu 
    50                  55                  60                  


Glu Ser Leu Leu Ser 
65                  

<210>  1156
<211>  1594
<212>  DNA
<213>  Homo sapiens

<400>  1156
ttgtccttca agtccagcat ggggtattcc ccatggagga gaagagggga gggaagaaga     60

gggaagatga aagagaacac aagtgggcag agaaattgtg caggtgcctt attccaagag    120

cctcctgcca tagcattgca cagttattca acattagtcc ttgacttgca gcaactgtgc    180

taagtgtatg ctgagcaaca ataattggag ccactaagaa atgtaattca aggaattgaa    240

ctttaatagt ctttgaacag gatctcctgg aatcatgtga aatcagaaga ggtaattctg    300

tattggtatt ggggtgaaag aggcaggtac atttagcttc tcctgtcaca ggtgacctca    360

caaagttcgg ccgtggggat gcctcctccc cagccccggc cacaaccttg gcccaacccc    420

aacagaacca gacgcagact caccatacca cgcagcagac attcctgaac ccggcgctgc    480

ctcctggcta cagttacacc agcctgccat actatacagg ggtcccgggc ctccccagca    540

ccttccagta tgggcctgct gtgttccctg tggctcctac ctcttccaag cagcatggtg    600

tgaatgtcag tgtgaatgca tcggccaccc ctttccaaca gccgagtgga tatgggtctc    660

atggatacaa cactggtgtt tcagtcacct ccagtaacac gggcgtgcca gatatctcgg    720

gttctgtgta ctccaaaacc cagcagtcct ttgagaaaca aggttttcat tccggtactc    780

ctgctgcttc cttcaacttg ccttcagccc taggaagtgg gggccccatc aatccggcca    840

cagctgctgc ctacccacct gcccccttta tgcacattct gaccccccat cagcagccgc    900

attctcagat ccttcaccat cacctgcagc aggatggcca gacgggcagc gggcaacgta    960

gccagaccag ctccatcccg cagaagcccc agaccaacaa gtctgcctac aacagctaca   1020

gctggggggc caactgaggc cctgaccctc ttctcccggt cccatcttct gagagggctt   1080

ctcagcctgg aaactatgga aacagcatca aagagaaagg aatgtggggg gtttccgctg   1140

ccccccaccc ccagcggccc accccatgcc tcagcttcat gtctgtccca ttcctatacc   1200

atccccaccc tgttgtatgt attataggat ttgtattttc tccttttttt tcccccttcc   1260

attccttctc ccctcttgca ttcaagatta tgaaactttg ctatgggccc tgcacttcct   1320

ttgcttcctc ctgttcaccc tggtggtgta cggatgaggc ggggaggtgg gacccccaaa   1380

catatatcag cccaacagcc ctaagtctcc ttctttatta ttaggaaaac aacaacaaca   1440

acaaacaaaa aaatggcgtc atgaatatga acagcattgt cagatgaatt agttgaagtg   1500

gttttttttt tgtttttttt ttttttttgt actgtgtcct caaatttaat ggattaatgt   1560

gtcttgtata tataaaaaga aaacctctac cttc                               1594


<210>  1157
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  1157


Met Ala Arg Arg Ala Ala Gly Asn Val Ala Arg Pro Ala Pro Ser Arg 
1               5                   10                  15      


Arg Ser Pro Arg Pro Thr Ser Leu Pro Thr Thr Ala Thr Ala Gly Gly 
            20                  25                  30          


Pro Thr Glu Ala Leu Thr Leu Phe Ser Arg Ser His Leu Leu Arg Gly 
        35                  40                  45              


Leu Leu Ser Leu Glu Thr Met Glu Thr Ala Ser Lys Arg Lys Glu Cys 
    50                  55                  60                  


Gly Gly Phe Pro Leu Pro Pro Thr Pro Ser Gly Pro Pro His Ala Ser 
65                  70                  75                  80  


Ala Ser Cys Leu Ser His Ser Tyr Thr Ile Pro Thr Leu Leu Tyr Val 
                85                  90                  95      


Leu 
    

<210>  1158
<211>  1055
<212>  DNA
<213>  Homo sapiens

<400>  1158
ttgtccttca agtccagcat ggggtattcc ccatggagga gaagagggga gggaagaaga     60

gggaagatga aagagaacac aagtgggcag agaaattgtg caggtgcctt attccaagag    120

cctcctgcca tagcattgca cagttattca acattagtcc ttgacttgca gcaactgtgc    180

taagtgtatg ctgagcaaca ataattggag ccactaagaa atgtaattca aggaattgaa    240

ctttaatagt ctttgaacag gatctcctgg aatcatgtga aatcagaaga ggtaattctg    300

tattggtatt ggggtgaaag aggcaggtac atttagcttc tcctgtcaca ggtgacctca    360

caaagttcgg ccgtggggat gcctcctccc cagccccggc cacaaccttg gcccaacccc    420

aacagaacca gacgcagact caccatacca cgcagcagac attcctgaac ccggcgctgc    480

ctcctggcta cagttacacc agcctgccat actatacagg ggtcccgggc ctccccagca    540

ccttccagta tgggcctgct gtgttccctg tggctcctac ctcttccaag cagcatggtg    600

tgaatgtcag tgtgaatgca tcggccaccc ctttccaaca gccgagtgga tatgggtctc    660

atggatacaa cactggtgtt tcagtcacct ccagtaacac gggcgtgcca gatatctcgg    720

gttctgtgta ctccaaaacc cagcagtcct ttgagaaaca aggttttcat tccggtactc    780

ctgctgcttc cttcaacttg ccttcagccc taggaagtgg gggccccatc aatccggcca    840

cagctgctgc ctacccacct gcccccttta tgcacattct gaccccccat cagcagccgc    900

attctcagat ccttcaccat cacctgcagc aggatggcca ggacatcctc aatttcgtcg    960

atgaccagct tggtgaataa gtattactgt accaactggg cctcctctag caggcccctg   1020

aaggcagtgg aataaaatga aatcttcgcc cttta                              1055


<210>  1159
<211>  65
<212>  PRT
<213>  Homo sapiens

<400>  1159


Met His Arg Pro Pro Leu Ser Asn Ser Arg Val Asp Met Gly Leu Met 
1               5                   10                  15      


Asp Thr Thr Leu Val Phe Gln Ser Pro Pro Val Thr Arg Ala Cys Gln 
            20                  25                  30          


Ile Ser Arg Val Leu Cys Thr Pro Lys Pro Ser Ser Pro Leu Arg Asn 
        35                  40                  45              


Lys Val Phe Ile Pro Val Leu Leu Leu Leu Pro Ser Thr Cys Leu Gln 
    50                  55                  60                  


Pro 
65  

<210>  1160
<211>  1118
<212>  DNA
<213>  Homo sapiens

<400>  1160
ttgtccttca agtccagcat ggggtattcc ccatggagga gaagagggga gggaagaaga     60

gggaagatga aagagaacac aagtgggcag agaaattgtg caggtgcctt attccaagag    120

cctcctgcca tagcattgca cagttattca acattagtcc ttgacttgca gcaactgtgc    180

taagtgtatg ctgagcaaca ataattggag ccactaagaa atgtaattca aggaattgaa    240

ctttaatagt ctttgaacag gatctcctgg aatcatgtga aatcagaaga ggtaattctg    300

tattggtatt ggggtgaaag aggcaggtac atttagcttc tcctgtcaca ggtgacctca    360

caaagttcgg ccgtggggat gcctcctccc cagccccggc cacaaccttg gcccaacccc    420

aacagaacca gacgcagact caccatacca cgcagcagac attcctgaac ccggcgctgc    480

ctcctggcta cagttacacc agcctgccat actatacagg ggtcccgggc ctccccagca    540

ccttccagta tgggcctgct gtgttccctg tggctcctac ctcttccaag cagcatggtg    600

tgaatgtcag tgtgaatgca tcggccaccc ctttccaaca gccgagtgga tatgggtctc    660

atggatacaa cactggtgtt tcagtcacct ccagtaacac gggcgtgcca gatatctcgg    720

gttctgtgta ctccaaaacc cagcagtcct ttgagaaaca aggttttcat tccggtactc    780

ctgctgcttc cttcaacttg ccttcagccc taggaagtgg gggccccatc aatccggcca    840

cagctgctgc ctacccacct gcccccttta tgcacattct gaccccccat cagcagccgc    900

attctcagat ccttcaccat cacctgcagc aggatggcca gctaccatat ttgcagatga    960

ttctctgttg ccagcgccag caggaggagc aggacatcct caatttcgtc gatgaccagc   1020

ttggtgaata agtattactg taccaactgg gcctcctcta gcaggcccct gaaggcagtg   1080

gaataaaatg aaatcttcgc cctttaagaa ctcctgac                           1118


<210>  1161
<211>  65
<212>  PRT
<213>  Homo sapiens

<400>  1161


Met His Arg Pro Pro Leu Ser Asn Ser Arg Val Asp Met Gly Leu Met 
1               5                   10                  15      


Asp Thr Thr Leu Val Phe Gln Ser Pro Pro Val Thr Arg Ala Cys Gln 
            20                  25                  30          


Ile Ser Arg Val Leu Cys Thr Pro Lys Pro Ser Ser Pro Leu Arg Asn 
        35                  40                  45              


Lys Val Phe Ile Pro Val Leu Leu Leu Leu Pro Ser Thr Cys Leu Gln 
    50                  55                  60                  


Pro 
65  

<210>  1162
<211>  2251
<212>  DNA
<213>  Homo sapiens

<400>  1162
ttgtccttca agtccagcat ggggtattcc ccatggagga gaagagggga gggaagaaga     60

gggaagatga aagagaacac aagtgggcag agaaattgtg caggtgcctt attccaagag    120

cctcctgcca tagcattgca cagttattca acattagtcc ttgacttgca gcaactgtgc    180

taagtgtatg ctgagcaaca ataattggag ccactaagaa atgtaattca aggaattgaa    240

ctttaatagt ctttgaacag gatctcctgg aatcatgtga aatcagaaga ggtaattctg    300

tattggtatt ggggtgaaag aggcaggtac atttagcttc tcctgtcaca ggtgacctca    360

caaagttcgg ccgtggggat gcctcctccc cagccccggc cacaaccttg gcccaacccc    420

aacagaacca gacgcagact caccatacca cgcagcagac attcctgaac ccggcgctgc    480

ctcctggcta cagttacacc agcctgccat actatacagg ggtcccgggc ctccccagca    540

ccttccagta tgggcctgct gtgttccctg tggctcctac ctcttccaag cagcatggtg    600

tgaatgtcag tgtgaatgca tcggccaccc ctttccaaca gccgagtgga tatgggtctc    660

atggatacaa cactggtgtt tcagtcacct ccagtaacac gggcgtgcca gatatctcgg    720

gttctgtgta ctccaaaacc cagcagtcct ttgagaaaca aggttttcat tccggtactc    780

ctgctgcttc cttcaacttg ccttcagccc taggaagtgg gggccccatc aatccggcca    840

cagctgctgc ctacccacct gcccccttta tgcacattct gaccccccat cagcagccgc    900

attctcagat ccttcaccat cacctgcagc aggatggcca gacgggcagc gggcaacgta    960

gccagaccag ctccatcccg cagaagcccc agaccaacaa gtctgcctac aacagctaca   1020

gctggggggc caactgaggc cctgaccctc ttctcccggt cccatcttct gagagggctt   1080

ctcagcctgg aaactatgga aacagcatca aagagaaagg aatgtggggg gtttccgctg   1140

ccccccaccc ccagcggccc accccatgcc tcagcttcat gtctgtccca ttcctatacc   1200

atccccaccc tgttgtatgt attataggat ttgtattttc tccttttttt tcccccttcc   1260

attccttctc ccctcttgca ttcaagatta tgaaactttg ctatgggccc tgcacttcct   1320

ttgcttcctc ctgttcaccc tggtggtgta cggatgaggc ggggaggtgg gacccccaaa   1380

catatatcag cccaacagcc ctaagtctcc ttctttatta ttaggaaaac aacaacaaca   1440

acaaacaaaa aaatggcgtc atgaatatga acagcattgt cagatgaatt agttgaagtg   1500

gttttttttt tgtttttttt ttttttttgt actgtgtcct caaatttaat ggattaatgt   1560

gtcttgtata tataaaaaga aaacctctac cttcagcctc tgcctattct tgctccgtct   1620

aggacatcct caatttcgtc gatgaccagc ttggtgaata agtattactg taccaactgg   1680

gcctcctcta gcaggcccct gaaggcagtg gaataaaatg aaatcttcgc cctttaagaa   1740

ctcctgacct taatgtggta gtagtatctt gtccttgagg ggatttcctt cccctcaccc   1800

ctaagacttt cacaacctgg tgactggaaa gaaccaccac aaatcttcat ttcctccaga   1860

aactgctaca tctacagccg atttcaggca gtaaagggag agggatagag gagattgggt   1920

ggaaaatgga gaggatcaag aaggagctga gaccatttca aagaaaaaaa atgctttata   1980

gagttttaag tatgacttag atgggtccag gcaaataaac taaaaagaag tgaaggcaac   2040

atgtatcgtc tggcagaact aaatcttgga gtggggtgag ggatgaaaga ctacatattg   2100

ggtacagtgt acactgctcg ggtgatgggt gcgctaaagt cgcagaaatc actaaagaac   2160

tcatccatgt aaccaaacac cacctgtacc ccaaaaacga aataaaaaaa caaaaccttg   2220

gggcccattc cccctaggaa tggactactg t                                  2251


<210>  1163
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  1163


Met Ala Arg Arg Ala Ala Gly Asn Val Ala Arg Pro Ala Pro Ser Arg 
1               5                   10                  15      


Arg Ser Pro Arg Pro Thr Ser Leu Pro Thr Thr Ala Thr Ala Gly Gly 
            20                  25                  30          


Pro Thr Glu Ala Leu Thr Leu Phe Ser Arg Ser His Leu Leu Arg Gly 
        35                  40                  45              


Leu Leu Ser Leu Glu Thr Met Glu Thr Ala Ser Lys Arg Lys Glu Cys 
    50                  55                  60                  


Gly Gly Phe Pro Leu Pro Pro Thr Pro Ser Gly Pro Pro His Ala Ser 
65                  70                  75                  80  


Ala Ser Cys Leu Ser His Ser Tyr Thr Ile Pro Thr Leu Leu Tyr Val 
                85                  90                  95      


Leu 
    

<210>  1164
<211>  1570
<212>  DNA
<213>  Homo sapiens

<400>  1164
ttgtccttca agtccagcat ggggtattcc ccatggagga gaagagggga gggaagaaga     60

gggaagatga aagagaacac aagtgggcag agaaattgtg caggtgcctt attccaagag    120

cctcctgcca tagcattgca cagttattca acattagtcc ttgacttgca gcaactgtgc    180

taagtgtatg ctgagcaaca ataattggag ccactaagaa atgtaattca aggaattgaa    240

ctttaatagt ctttgaacag gatctcctgg aatcatgtga aatcagaaga ggtaattctg    300

tattggtatt ggggtgaaag aggcaggtac atttagcttc tcctgtcaca ggtgacctca    360

caaagttcgg ccgtggggat gcctcctccc cagccccggc cacaaccttg gcccaacccc    420

aacagaacca gacgcagact caccatacca cgcagcagac attcctgaac ccggcgctgc    480

ctcctggcta cagttacacc agcctgccat actatacagg ggtcccgggc ctccccagca    540

ccttccagta tgggcctgct gtgttccctg tggctcctac ctcttccaag cagcatggtg    600

tgaatgtcag tgtgaatgca tcggccaccc ctttccaaca gccgagtgga tatgggtctc    660

atggatacaa cactggtgtt tcagtcacct ccagtaacac gggcgtgcca gatatctcgg    720

gttctgtgta ctccaaaacc cagcagtcct ttgagaaaca aggttttcat tccggtactc    780

ctgctgcttc cttcaacttg ccttcagccc taggaagtgg gggccccatc aatccggcca    840

cagctgctgc ctacccacct gcccccttta tgcacattct gaccccccat cagcagccgc    900

attctcagat ccttcaccat cacctgcagc aggatggcca ggacatcctc aatttcgtcg    960

atgaccagct tggtgaataa gtattactgt accaactggg cctcctctag caggcccctg   1020

aaggcagtgg aataaaatga aatcttcgcc ctttaagaac tcctgacctt aatgtggtag   1080

tagtatcttg tccttgaggg gatttccttc ccctcacccc taagactttc acaacctggt   1140

gactggaaag aaccaccaca aatcttcatt tcctccagaa actgctacat ctacagccga   1200

tttcaggcag taaagggaga gggatagagg agattgggtg gaaaatggag aggatcaaga   1260

aggagctgag accatttcaa agaaaaaaaa tgctttatag agttttaagt atgacttaga   1320

tgggtccagg caaataaact aaaaagaagt gaaggcaaca tgtatcgtct ggcagaacta   1380

aatcttggag tggggtgagg gatgaaagac tacatattgg gtacagtgta cactgctcgg   1440

gtgatgggtg cgctaaagtc gcagaaatca ctaaagaact catccatgta accaaacacc   1500

acctgtaccc caaaaacgaa ataaaaaaac aaaaccttgg ggcccattcc ccctaggaat   1560

ggactactgt                                                          1570


<210>  1165
<211>  65
<212>  PRT
<213>  Homo sapiens

<400>  1165


Met His Arg Pro Pro Leu Ser Asn Ser Arg Val Asp Met Gly Leu Met 
1               5                   10                  15      


Asp Thr Thr Leu Val Phe Gln Ser Pro Pro Val Thr Arg Ala Cys Gln 
            20                  25                  30          


Ile Ser Arg Val Leu Cys Thr Pro Lys Pro Ser Ser Pro Leu Arg Asn 
        35                  40                  45              


Lys Val Phe Ile Pro Val Leu Leu Leu Leu Pro Ser Thr Cys Leu Gln 
    50                  55                  60                  


Pro 
65  

<210>  1166
<211>  481
<212>  DNA
<213>  Homo sapiens

<400>  1166
ggtgtgaatg tcagtgtgaa tgcatcggcc acccctttcc aacagccgag tggatatggg     60

tctcatggat acaacactgg aagaaaatat ccaccccctt acaagcattt ctggacggct    120

gagagctaat ttggcccaag gctgggggct gtgttttgtg tgtgtgtata aatttgcact    180

gaagtcttgt ttcagaaacc agaccactga ggagagcctg ctgagctgag gccatggcct    240

gcgtggcttg gggaaatgag ttggtggata ccttctgggc ttttgaactt gcccctcccc    300

catttccctc tcccccatgt gtctgaccct gtcttaccca tttcaagttc aagcggtgca    360

gcaccttcga agcatcaatg cacacacctg ctgttgcttt tgatttctgg aaggcatgta    420

gtttcaactt gtaacaaaaa tatttgtagt cttcaataaa ctgtggtatt tctttagcta    480

a                                                                    481


<210>  1167
<211>  69
<212>  PRT
<213>  Homo sapiens

<400>  1167


Met His Arg Pro Pro Leu Ser Asn Ser Arg Val Asp Met Gly Leu Met 
1               5                   10                  15      


Asp Thr Thr Leu Glu Glu Asn Ile His Pro Leu Thr Ser Ile Ser Gly 
            20                  25                  30          


Arg Leu Arg Ala Asn Leu Ala Gln Gly Trp Gly Leu Cys Phe Val Cys 
        35                  40                  45              


Val Tyr Lys Phe Ala Leu Lys Ser Cys Phe Arg Asn Gln Thr Thr Glu 
    50                  55                  60                  


Glu Ser Leu Leu Ser 
65                  

<210>  1168
<211>  989
<212>  DNA
<213>  Homo sapiens

<400>  1168
gtcagtgtga atgcatcggc cacccctttc caacagccga gtggatatgg gtctcatgga     60

tacaacactg gtgtttcagt cacctccagt aacacgggcg tgccagatat ctcgggttct    120

gtgtactcca aaacccagca gtcctttgag aaacaaggtt ttcattccgg tactcctgct    180

gcttccttca acttgccttc agccctagga agtgggggcc ccatcaatcc ggccacagct    240

gctgcctacc cacctgcccc ctttatgcac attctgaccc cccatcagca gccgcattct    300

cagatccttc accatcacct gcagcaggat ggccagacgg gcagcgggca acgtagccag    360

accagctcca tcccgcagaa gccccagacc aacaagtctg cctacaacag ctacagctgg    420

ggggccaact gaggccctga ccctcttctc ccggtcccat cttctgagag ggcttctcag    480

cctggaaact atggaaacag catcaaagag aaaggaatgt ggggggtttc cgctgccccc    540

cacccccagc ggcccacccc atgcctcagc ttcatgtctg tcccattcct ataccatccc    600

caccctgttg tatgtattat aggatttgta ttttctcctt ttttttcccc cttccattcc    660

ttctcccctc ttgcattcaa gattatgaaa ctttgctatg ggccctgcac ttcctttgct    720

tcctcctgtt caccctggtg gtgtacggat gaggcgggga ggtgggaccc ccaaacatat    780

atcagcccaa cagccctaag tctccttctt tattattagg aaaacaacaa caacaacaaa    840

caaaaaaatg gcgtcatgaa tatgaacagc attgtcagat gaattagttg aagtggtttt    900

ttttttgttt tttttttttt tttgtactgt gtcctcaaat ttaatggatt aatgtgtctt    960

gtatatataa aaagaaaacc tctaccttc                                      989


<210>  1169
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  1169


Met Ala Arg Arg Ala Ala Gly Asn Val Ala Arg Pro Ala Pro Ser Arg 
1               5                   10                  15      


Arg Ser Pro Arg Pro Thr Ser Leu Pro Thr Thr Ala Thr Ala Gly Gly 
            20                  25                  30          


Pro Thr Glu Ala Leu Thr Leu Phe Ser Arg Ser His Leu Leu Arg Gly 
        35                  40                  45              


Leu Leu Ser Leu Glu Thr Met Glu Thr Ala Ser Lys Arg Lys Glu Cys 
    50                  55                  60                  


Gly Gly Phe Pro Leu Pro Pro Thr Pro Ser Gly Pro Pro His Ala Ser 
65                  70                  75                  80  


Ala Ser Cys Leu Ser His Ser Tyr Thr Ile Pro Thr Leu Leu Tyr Val 
                85                  90                  95      


Leu 
    

<210>  1170
<211>  1016
<212>  DNA
<213>  Homo sapiens

<400>  1170
gtcagtgtga atgcatcggc cacccctttc caacagccga gtggatatgg gtctcatgga     60

tacaacactg gtgtttcagt cacctccagt aacacgggcg tgccagatat ctcgggttct    120

gtgtactcca aaacccagca gtcctttgag aaacaaggtt ttcattccgg tactcctgct    180

gcttccttca acttgccttc agccctagga agtgggggcc ccatcaatcc ggccacagct    240

gctgcctacc cacctgcccc ctttatgcac attctgaccc cccatcagca gccgcattct    300

cagatccttc accatcacct gcagcaggat ggccagctac catatttgca gatgattctc    360

tgttgccagc gccagcagga ggagcaggac atcctcaatt tcgtcgatga ccagcttggt    420

gaataagtat tactgtacca actgggcctc ctctagcagg cccctgaagg cagtggaata    480

aaatgaaatc ttcgcccttt aagaactcct gaccttaatg tggtagtagt atcttgtcct    540

tgaggggatt tccttcccct cacccctaag actttcacaa cctggtgact ggaaagaacc    600

accacaaatc ttcatttcct ccagaaactg ctacatctac agccgatttc aggcagtaaa    660

gggagaggga tagaggagat tgggtggaaa atggagagga tcaagaagga gctgagacca    720

tttcaaagaa aaaaaatgct ttatagagtt ttaagtatga cttagatggg tccaggcaaa    780

taaactaaaa agaagtgaag gcaacatgta tcgtctggca gaactaaatc ttggagtggg    840

gtgagggatg aaagactaca tattgggtac agtgtacact gctcgggtga tgggtgcgct    900

aaagtcgcag aaatcactaa agaactcatc catgtaacca aacaccacct gtaccccaaa    960

aacgaaataa aaaaacaaaa ccttggggcc cattccccct aggaatggac tactgt       1016


<210>  1171
<211>  65
<212>  PRT
<213>  Homo sapiens

<400>  1171


Met His Arg Pro Pro Leu Ser Asn Ser Arg Val Asp Met Gly Leu Met 
1               5                   10                  15      


Asp Thr Thr Leu Val Phe Gln Ser Pro Pro Val Thr Arg Ala Cys Gln 
            20                  25                  30          


Ile Ser Arg Val Leu Cys Thr Pro Lys Pro Ser Ser Pro Leu Arg Asn 
        35                  40                  45              


Lys Val Phe Ile Pro Val Leu Leu Leu Leu Pro Ser Thr Cys Leu Gln 
    50                  55                  60                  


Pro 
65  

<210>  1172
<211>  965
<212>  DNA
<213>  Homo sapiens

<400>  1172
gtcagtgtga atgcatcggc cacccctttc caacagccga gtggatatgg gtctcatgga     60

tacaacactg gtgtttcagt cacctccagt aacacgggcg tgccagatat ctcgggttct    120

gtgtactcca aaacccagca gtcctttgag aaacaaggtt ttcattccgg tactcctgct    180

gcttccttca acttgccttc agccctagga agtgggggcc ccatcaatcc ggccacagct    240

gctgcctacc cacctgcccc ctttatgcac attctgaccc cccatcagca gccgcattct    300

cagatccttc accatcacct gcagcaggat ggccaggaca tcctcaattt cgtcgatgac    360

cagcttggtg aataagtatt actgtaccaa ctgggcctcc tctagcaggc ccctgaaggc    420

agtggaataa aatgaaatct tcgcccttta agaactcctg accttaatgt ggtagtagta    480

tcttgtcctt gaggggattt ccttcccctc acccctaaga ctttcacaac ctggtgactg    540

gaaagaacca ccacaaatct tcatttcctc cagaaactgc tacatctaca gccgatttca    600

ggcagtaaag ggagagggat agaggagatt gggtggaaaa tggagaggat caagaaggag    660

ctgagaccat ttcaaagaaa aaaaatgctt tatagagttt taagtatgac ttagatgggt    720

ccaggcaaat aaactaaaaa gaagtgaagg caacatgtat cgtctggcag aactaaatct    780

tggagtgggg tgagggatga aagactacat attgggtaca gtgtacactg ctcgggtgat    840

gggtgcgcta aagtcgcaga aatcactaaa gaactcatcc atgtaaccaa acaccacctg    900

taccccaaaa acgaaataaa aaaacaaaac cttggggccc attcccccta ggaatggact    960

actgt                                                                965


<210>  1173
<211>  65
<212>  PRT
<213>  Homo sapiens

<400>  1173


Met His Arg Pro Pro Leu Ser Asn Ser Arg Val Asp Met Gly Leu Met 
1               5                   10                  15      


Asp Thr Thr Leu Val Phe Gln Ser Pro Pro Val Thr Arg Ala Cys Gln 
            20                  25                  30          


Ile Ser Arg Val Leu Cys Thr Pro Lys Pro Ser Ser Pro Leu Arg Asn 
        35                  40                  45              


Lys Val Phe Ile Pro Val Leu Leu Leu Leu Pro Ser Thr Cys Leu Gln 
    50                  55                  60                  


Pro 
65  

<210>  1174
<211>  1646
<212>  DNA
<213>  Homo sapiens

<400>  1174
gtcagtgtga atgcatcggc cacccctttc caacagccga gtggatatgg gtctcatgga     60

tacaacactg gtgtttcagt cacctccagt aacacgggcg tgccagatat ctcgggttct    120

gtgtactcca aaacccagca gtcctttgag aaacaaggtt ttcattccgg tactcctgct    180

gcttccttca acttgccttc agccctagga agtgggggcc ccatcaatcc ggccacagct    240

gctgcctacc cacctgcccc ctttatgcac attctgaccc cccatcagca gccgcattct    300

cagatccttc accatcacct gcagcaggat ggccagacgg gcagcgggca acgtagccag    360

accagctcca tcccgcagaa gccccagacc aacaagtctg cctacaacag ctacagctgg    420

ggggccaact gaggccctga ccctcttctc ccggtcccat cttctgagag ggcttctcag    480

cctggaaact atggaaacag catcaaagag aaaggaatgt ggggggtttc cgctgccccc    540

cacccccagc ggcccacccc atgcctcagc ttcatgtctg tcccattcct ataccatccc    600

caccctgttg tatgtattat aggatttgta ttttctcctt ttttttcccc cttccattcc    660

ttctcccctc ttgcattcaa gattatgaaa ctttgctatg ggccctgcac ttcctttgct    720

tcctcctgtt caccctggtg gtgtacggat gaggcgggga ggtgggaccc ccaaacatat    780

atcagcccaa cagccctaag tctccttctt tattattagg aaaacaacaa caacaacaaa    840

caaaaaaatg gcgtcatgaa tatgaacagc attgtcagat gaattagttg aagtggtttt    900

ttttttgttt tttttttttt tttgtactgt gtcctcaaat ttaatggatt aatgtgtctt    960

gtatatataa aaagaaaacc tctaccttca gcctctgcct attcttgctc cgtctaggac   1020

atcctcaatt tcgtcgatga ccagcttggt gaataagtat tactgtacca actgggcctc   1080

ctctagcagg cccctgaagg cagtggaata aaatgaaatc ttcgcccttt aagaactcct   1140

gaccttaatg tggtagtagt atcttgtcct tgaggggatt tccttcccct cacccctaag   1200

actttcacaa cctggtgact ggaaagaacc accacaaatc ttcatttcct ccagaaactg   1260

ctacatctac agccgatttc aggcagtaaa gggagaggga tagaggagat tgggtggaaa   1320

atggagagga tcaagaagga gctgagacca tttcaaagaa aaaaaatgct ttatagagtt   1380

ttaagtatga cttagatggg tccaggcaaa taaactaaaa agaagtgaag gcaacatgta   1440

tcgtctggca gaactaaatc ttggagtggg gtgagggatg aaagactaca tattgggtac   1500

agtgtacact gctcgggtga tgggtgcgct aaagtcgcag aaatcactaa agaactcatc   1560

catgtaacca aacaccacct gtaccccaaa aacgaaataa aaaaacaaaa ccttggggcc   1620

cattccccct aggaatggac tactgt                                        1646


<210>  1175
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  1175


Met Ala Arg Arg Ala Ala Gly Asn Val Ala Arg Pro Ala Pro Ser Arg 
1               5                   10                  15      


Arg Ser Pro Arg Pro Thr Ser Leu Pro Thr Thr Ala Thr Ala Gly Gly 
            20                  25                  30          


Pro Thr Glu Ala Leu Thr Leu Phe Ser Arg Ser His Leu Leu Arg Gly 
        35                  40                  45              


Leu Leu Ser Leu Glu Thr Met Glu Thr Ala Ser Lys Arg Lys Glu Cys 
    50                  55                  60                  


Gly Gly Phe Pro Leu Pro Pro Thr Pro Ser Gly Pro Pro His Ala Ser 
65                  70                  75                  80  


Ala Ser Cys Leu Ser His Ser Tyr Thr Ile Pro Thr Leu Leu Tyr Val 
                85                  90                  95      


Leu 
    

<210>  1176
<211>  1227
<212>  DNA
<213>  Homo sapiens

<400>  1176
aaagataaag cctttcaaat ttgaggaaga ccttcggtcc cgcctccatt tcacgtccgg     60

cttaccgtcg tttacgacag tgtcaggatc gcgggcttgc tttccggtag cgtgggctga    120

cgcctcgctc aatttctcac agggctgcgc aggtttcccc cgtctgcgaa tggaccactg    180

gaggggttca aaggttcgcg tcccagtacg ggaatgagcc tctttgatct cttccggggc    240

tttttcggct ttcctggacc tcggagccac agagatccct tttttggagg gatgactcga    300

gatgaagatg atgatgagga agaagaagaa gaagggggct catggggccg tgggaaccca    360

aggttccata gtcctcagca cccccctgag gaatttggct tcggcttcag cttcagccca    420

ggaggaggga tacgtttcca cgataacttc ggctttgatg acctagtacg agatttcaat    480

agcatcttca gcgatatggg ggcctggacc ttgccttccc atcctcctga acttccaggt    540

cctgagtcag agacacctgg tgagagacta cgggagggac agacacttcg ggactcaatg    600

cttaagtatc cagatagtca ccagcccagg atctttgggg gggtcttgga gagtgatgca    660

agaagtgaat ccccccaacc agcaccagac tggggctccc agaggccatt tcataggttt    720

gatgatgtat ggcctatgga cccccatcct agaaccagag aggacaatga tcttgattcc    780

caggtttccc aggagggtct tggcccggtt ctacagcccc agcccaaatc ctatttcaag    840

agcatctctg tgaccaagat cactaaacca gatgggatag tggaggagcg ccggactgtg    900

gtggacagtg agggccggac agagactaca gtaacccgac acgaagcaga tagcagtcct    960

aggggtgatc cagaatcacc aagacctcca gccctggatg atgccttttc catcctggac   1020

ttattcctgg gacgttggtt ccggtcccgg tagccttgtt aaccctcaga ggccttcaag   1080

tcctttccac ctctcaccca ttgcccacca ttaataagct tagcttctct tgccacctca   1140

ggggcttgga tatgtggaat agtgaactgg ggccatgtca gtttgtcact cacccaaact   1200

gaccaataaa acctttattt atgctaa                                       1227


<210>  1177
<211>  279
<212>  PRT
<213>  Homo sapiens

<400>  1177


Met Ser Leu Phe Asp Leu Phe Arg Gly Phe Phe Gly Phe Pro Gly Pro 
1               5                   10                  15      


Arg Ser His Arg Asp Pro Phe Phe Gly Gly Met Thr Arg Asp Glu Asp 
            20                  25                  30          


Asp Asp Glu Glu Glu Glu Glu Glu Gly Gly Ser Trp Gly Arg Gly Asn 
        35                  40                  45              


Pro Arg Phe His Ser Pro Gln His Pro Pro Glu Glu Phe Gly Phe Gly 
    50                  55                  60                  


Phe Ser Phe Ser Pro Gly Gly Gly Ile Arg Phe His Asp Asn Phe Gly 
65                  70                  75                  80  


Phe Asp Asp Leu Val Arg Asp Phe Asn Ser Ile Phe Ser Asp Met Gly 
                85                  90                  95      


Ala Trp Thr Leu Pro Ser His Pro Pro Glu Leu Pro Gly Pro Glu Ser 
            100                 105                 110         


Glu Thr Pro Gly Glu Arg Leu Arg Glu Gly Gln Thr Leu Arg Asp Ser 
        115                 120                 125             


Met Leu Lys Tyr Pro Asp Ser His Gln Pro Arg Ile Phe Gly Gly Val 
    130                 135                 140                 


Leu Glu Ser Asp Ala Arg Ser Glu Ser Pro Gln Pro Ala Pro Asp Trp 
145                 150                 155                 160 


Gly Ser Gln Arg Pro Phe His Arg Phe Asp Asp Val Trp Pro Met Asp 
                165                 170                 175     


Pro His Pro Arg Thr Arg Glu Asp Asn Asp Leu Asp Ser Gln Val Ser 
            180                 185                 190         


Gln Glu Gly Leu Gly Pro Val Leu Gln Pro Gln Pro Lys Ser Tyr Phe 
        195                 200                 205             


Lys Ser Ile Ser Val Thr Lys Ile Thr Lys Pro Asp Gly Ile Val Glu 
    210                 215                 220                 


Glu Arg Arg Thr Val Val Asp Ser Glu Gly Arg Thr Glu Thr Thr Val 
225                 230                 235                 240 


Thr Arg His Glu Ala Asp Ser Ser Pro Arg Gly Asp Pro Glu Ser Pro 
                245                 250                 255     


Arg Pro Pro Ala Leu Asp Asp Ala Phe Ser Ile Leu Asp Leu Phe Leu 
            260                 265                 270         


Gly Arg Trp Phe Arg Ser Arg 
        275                 

<210>  1178
<211>  1143
<212>  DNA
<213>  Homo sapiens

<400>  1178
ttgaggaaga ccttcggtcc cgcctccatt tcacgtccgg cttaccgtcg tttacgacag     60

tgtcaggatc gcgggcttgc tttccggtag cgtgggctga cgcctcgctc aatttctcac    120

agggctgcgc aggtttcccc cgtctgcgaa tggaccactg gaggggttca aaggttcgcg    180

tcccagtacg ggaatgagcc tctttgatct cttccggggc tttttcggct ttcctggacc    240

tcggagccac agagatccct tttttggagg gatgactcga gatgaagatg atgatgagga    300

agaagaagaa gaagggggct catggggccg tgggaaccca aggttccata gtcctcagca    360

cccccctgag gaatttggct tcggcttcag cttcagccca ggaggaggga tacgtttcca    420

cgataacttc ggctttgatg acctaaactt ccaggtcctg agtcagagac acctggtgag    480

agactacggg agggacagac acttcgggac tcaatgctta agtatccaga tagtcaccag    540

cccaggatct ttgggggggt cttggagagt gatgcaagaa gtgaatcccc ccaaccagca    600

ccagactggg gctcccagag gccatttcat aggtttgatg atgtatggcc tatggacccc    660

catcctagaa ccagagagga caatgatctt gattcccagg tttcccagga gggtcttggc    720

ccggttctac agccccagcc caaatcctat ttcaagagca tctctgtgac caagatcact    780

aaaccagatg ggatagtgga ggagcgccgg actgtggtgg acagtgaggg ccggacagag    840

actacagtaa cccgacacga agcagatagc agtcctaggg gtgatccaga atcaccaaga    900

cctccagccc tggatgatgc cttttccatc ctggacttat tcctgggacg ttggttccgg    960

tcccggtagc cttgttaacc ctcagaggcc ttcaagtcct ttccacctct cacccattgc   1020

ccaccattaa taagcttagc ttctcttgcc acctcagggg cttggatatg tggaatagtg   1080

aactggggcc atgtcagttt gtcactcacc caaactgacc aataaaacct ttatttatgc   1140

taa                                                                 1143


<210>  1179
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  1179


Met Ser Leu Phe Asp Leu Phe Arg Gly Phe Phe Gly Phe Pro Gly Pro 
1               5                   10                  15      


Arg Ser His Arg Asp Pro Phe Phe Gly Gly Met Thr Arg Asp Glu Asp 
            20                  25                  30          


Asp Asp Glu Glu Glu Glu Glu Glu Gly Gly Ser Trp Gly Arg Gly Asn 
        35                  40                  45              


Pro Arg Phe His Ser Pro Gln His Pro Pro Glu Glu Phe Gly Phe Gly 
    50                  55                  60                  


Phe Ser Phe Ser Pro Gly Gly Gly Ile Arg Phe His Asp Asn Phe Gly 
65                  70                  75                  80  


Phe Asp Asp Leu Asn Phe Gln Val Leu Ser Gln Arg His Leu Val Arg 
                85                  90                  95      


Asp Tyr Gly Arg Asp Arg His Phe Gly Thr Gln Cys Leu Ser Ile Gln 
            100                 105                 110         


Ile Val Thr Ser Pro Gly Ser Leu Gly Gly Ser Trp Arg Val Met Gln 
        115                 120                 125             


Glu Val Asn Pro Pro Asn Gln His Gln Thr Gly Ala Pro Arg Gly His 
    130                 135                 140                 


Phe Ile Gly Leu Met Met Tyr Gly Leu Trp Thr Pro Ile Leu Glu Pro 
145                 150                 155                 160 


Glu Arg Thr Met Ile Leu Ile Pro Arg Phe Pro Arg Arg Val Leu Ala 
                165                 170                 175     


Arg Phe Tyr Ser Pro Ser Pro Asn Pro Ile Ser Arg Ala Ser Leu 
            180                 185                 190     

<210>  1180
<211>  1031
<212>  DNA
<213>  Homo sapiens

<400>  1180
acgtccggct taccgtcgtt tacgacagtg tcaggatcgc gggcttgctt tccggtagcg     60

tgggctgacg cctcgctcaa tttctcacag ggctgcgcag gtttcccccg tctgcgaatg    120

gaccactgga ggggttcaaa ggttcgcgtc ccagtacggg aatgagcctc tttgatctct    180

tccggggctt tttcggcttt cctggacctc ggagcttcag cccaggagga gggatacgtt    240

tccacgataa cttcggcttt gatgacctag tacgagattt caatagcatc ttcagcgata    300

tgggggcctg gaccttgcct tcccatcctc ctgaacttcc aggtcctgag tcagagacac    360

ctggtgagag actacgggag ggacagacac ttcgggactc aatgcttaag tatccagata    420

gtcaccagcc caggatcttt gggggggtct tggagagtga tgcaagaagt gaatcccccc    480

aaccagcacc agactggggc tcccagaggc catttcatag gtttgatgat gtatggccta    540

tggaccccca tcctagaacc agagaggaca atgatcttga ttcccaggtt tcccaggagg    600

gtcttggccc ggttctacag ccccagccca aatcctattt caagagcatc tctgtgacca    660

agatcactaa accagatggg atagtggagg agcgccggac tgtggtggac agtgagggcc    720

ggacagagac tacagtaacc cgacacgaag cagatagcag tcctaggggt gatccagaat    780

caccaagacc tccagccctg gatgatgcct tttccatcct ggacttattc ctgggacgtt    840

ggttccggtc ccggtagcct tgttaaccct cagaggcctt caagtccttt ccacctctca    900

cccattgccc accattaata agcttagctt ctcttgccac ctcaggggct tggatatgtg    960

gaatagtgaa ctggggccat gtcagtttgt cactcaccca aactgaccaa taaaaccttt   1020

atttatgcta a                                                        1031


<210>  1181
<211>  231
<212>  PRT
<213>  Homo sapiens

<400>  1181


Met Ser Leu Phe Asp Leu Phe Arg Gly Phe Phe Gly Phe Pro Gly Pro 
1               5                   10                  15      


Arg Ser Phe Ser Pro Gly Gly Gly Ile Arg Phe His Asp Asn Phe Gly 
            20                  25                  30          


Phe Asp Asp Leu Val Arg Asp Phe Asn Ser Ile Phe Ser Asp Met Gly 
        35                  40                  45              


Ala Trp Thr Leu Pro Ser His Pro Pro Glu Leu Pro Gly Pro Glu Ser 
    50                  55                  60                  


Glu Thr Pro Gly Glu Arg Leu Arg Glu Gly Gln Thr Leu Arg Asp Ser 
65                  70                  75                  80  


Met Leu Lys Tyr Pro Asp Ser His Gln Pro Arg Ile Phe Gly Gly Val 
                85                  90                  95      


Leu Glu Ser Asp Ala Arg Ser Glu Ser Pro Gln Pro Ala Pro Asp Trp 
            100                 105                 110         


Gly Ser Gln Arg Pro Phe His Arg Phe Asp Asp Val Trp Pro Met Asp 
        115                 120                 125             


Pro His Pro Arg Thr Arg Glu Asp Asn Asp Leu Asp Ser Gln Val Ser 
    130                 135                 140                 


Gln Glu Gly Leu Gly Pro Val Leu Gln Pro Gln Pro Lys Ser Tyr Phe 
145                 150                 155                 160 


Lys Ser Ile Ser Val Thr Lys Ile Thr Lys Pro Asp Gly Ile Val Glu 
                165                 170                 175     


Glu Arg Arg Thr Val Val Asp Ser Glu Gly Arg Thr Glu Thr Thr Val 
            180                 185                 190         


Thr Arg His Glu Ala Asp Ser Ser Pro Arg Gly Asp Pro Glu Ser Pro 
        195                 200                 205             


Arg Pro Pro Ala Leu Asp Asp Ala Phe Ser Ile Leu Asp Leu Phe Leu 
    210                 215                 220                 


Gly Arg Trp Phe Arg Ser Arg 
225                 230     

<210>  1182
<211>  627
<212>  DNA
<213>  Homo sapiens

<400>  1182
gtcgtttacg acagtgtcag gatcgcgggc ttgctttccg gtagcgtggg ctgacgcctc     60

gctcaatttc tcacagggct gcgcaggttt cccccgtctg cgaatggacc actggagggg    120

ttcaaaggtt cgcgtcccag tacgggaatg agcctctttg atctcttccg gggctttttc    180

ggctttcctg gacctcggag ccacagagat cccttttttg gagggatgac tcgagatgaa    240

gatgatgatg aggaagaaga agaagaaggg ggctcatggg gccgtgggaa cccaaggttc    300

catagtcctc agcacccccc tgaggaattt ggcttcggct tcagcttcag cccaggagga    360

gggatacgtt tccacgataa cttcggcttt gatgacctag tacgagattt caatagcatc    420

ttcagcgata tgggggcctg gaccttgcct tcccatcctc ctgaacttcc aggtcctgag    480

tcagagacac ctggtgagag actacgggag ggacagacac ttcgggactc aatgcttaag    540

tatccagata gtcaccagcc caggatcttt gggggggtct tggagagtga tgcaagaagt    600

gaatcccccc aaccagcacc agactgg                                        627


<210>  1183
<211>  159
<212>  PRT
<213>  Homo sapiens

<400>  1183


Met Ser Leu Phe Asp Leu Phe Arg Gly Phe Phe Gly Phe Pro Gly Pro 
1               5                   10                  15      


Arg Ser His Arg Asp Pro Phe Phe Gly Gly Met Thr Arg Asp Glu Asp 
            20                  25                  30          


Asp Asp Glu Glu Glu Glu Glu Glu Gly Gly Ser Trp Gly Arg Gly Asn 
        35                  40                  45              


Pro Arg Phe His Ser Pro Gln His Pro Pro Glu Glu Phe Gly Phe Gly 
    50                  55                  60                  


Phe Ser Phe Ser Pro Gly Gly Gly Ile Arg Phe His Asp Asn Phe Gly 
65                  70                  75                  80  


Phe Asp Asp Leu Val Arg Asp Phe Asn Ser Ile Phe Ser Asp Met Gly 
                85                  90                  95      


Ala Trp Thr Leu Pro Ser His Pro Pro Glu Leu Pro Gly Pro Glu Ser 
            100                 105                 110         


Glu Thr Pro Gly Glu Arg Leu Arg Glu Gly Gln Thr Leu Arg Asp Ser 
        115                 120                 125             


Met Leu Lys Tyr Pro Asp Ser His Gln Pro Arg Ile Phe Gly Gly Val 
    130                 135                 140                 


Leu Glu Ser Asp Ala Arg Ser Glu Ser Pro Gln Pro Ala Pro Asp 
145                 150                 155                 

<210>  1184
<211>  720
<212>  DNA
<213>  Homo sapiens

<400>  1184
gacagtgtca ggatcgcggg cttgctttcc ggtagcgtgg gctgacgcct cgctcaattt     60

ctcacagggc tgcgcaggtt tcccccgtct gcgaatggac cactggaggg gttcaaaggt    120

tcgcgtccca gtacgggaat gagcctcttt gatctcttcc ggggcttttt cggctttcct    180

ggacctcgga gccacagaga tccctttttt ggagggatga ctcgagatga agatgatgat    240

gaggaagaag aagaagaagg gggctcatgg ggccgtggga acccaaggtt ccatagtcct    300

cagcaccccc ctgaggaatt tggcttcggc ttcagcttca gcccaggagg agggatacgt    360

ttccacgata acttcggctt tgatgaccta gtacgagatt tcaatagcat cttcagcgat    420

atgggggcct ggaccttgcc ttcccatcct cctggtgtgt ggctttccct aaggggcaac    480

ctgtggtttc tggtgggttg gtgggtgaaa taaagagcct gcagggagta gctgggggat    540

gggaagtgtg agaagactga tgatttcaga gagattaata gagcccaagt cctttcccat    600

cccagcaaac acctgccacc tttctgcaga acttccaggt cctgagtcag agacacctgg    660

tgagagacta cgggagggac agacacttcg ggactcaatg cttaagtatc cagatagtca    720


<210>  1185
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  1185


Met Ser Leu Phe Asp Leu Phe Arg Gly Phe Phe Gly Phe Pro Gly Pro 
1               5                   10                  15      


Arg Ser His Arg Asp Pro Phe Phe Gly Gly Met Thr Arg Asp Glu Asp 
            20                  25                  30          


Asp Asp Glu Glu Glu Glu Glu Glu Gly Gly Ser Trp Gly Arg Gly Asn 
        35                  40                  45              


Pro Arg Phe His Ser Pro Gln His Pro Pro Glu Glu Phe Gly Phe Gly 
    50                  55                  60                  


Phe Ser Phe Ser Pro Gly Gly Gly Ile Arg Phe His Asp Asn Phe Gly 
65                  70                  75                  80  


Phe Asp Asp Leu Val Arg Asp Phe Asn Ser Ile Phe Ser Asp Met Gly 
                85                  90                  95      


Ala Trp Thr Leu Pro Ser His Pro Pro Gly Val Trp Leu Ser Leu Arg 
            100                 105                 110         


Gly Asn Leu Trp Phe Leu Val Gly Trp Trp Val Lys 
        115                 120                 

<210>  1186
<211>  403
<212>  DNA
<213>  Homo sapiens

<400>  1186
gacagtgtca ggatcgcggg cttgctttcc ggtagcgtgg gctgacgcct cgctcaattt     60

ctcacagggc tgcgcaggtt tcccccgtct gcgaatggac cactggaggg gttcaaaggt    120

tcgcgtccca gtacgggaat gagcctcttt gatctcttcc ggggcttttt cggctttcct    180

ggacctcgga gcttcagccc aggaggaggg atacgtttcc acgataactt cggctttgat    240

gacctagtac gagatttcaa tagcatcttc agcgatatgg gggcctggac cttgccttcc    300

catcctcctg aacttccagg tcctgagtca gagacacctg gtgagagact acgggaggga    360

cagacacttc gggactcaat gcttaagtat ccagatagtc acc                      403


<210>  1187
<211>  87
<212>  PRT
<213>  Homo sapiens

<400>  1187


Met Ser Leu Phe Asp Leu Phe Arg Gly Phe Phe Gly Phe Pro Gly Pro 
1               5                   10                  15      


Arg Ser Phe Ser Pro Gly Gly Gly Ile Arg Phe His Asp Asn Phe Gly 
            20                  25                  30          


Phe Asp Asp Leu Val Arg Asp Phe Asn Ser Ile Phe Ser Asp Met Gly 
        35                  40                  45              


Ala Trp Thr Leu Pro Ser His Pro Pro Glu Leu Pro Gly Pro Glu Ser 
    50                  55                  60                  


Glu Thr Pro Gly Glu Arg Leu Arg Glu Gly Gln Thr Leu Arg Asp Ser 
65                  70                  75                  80  


Met Leu Lys Tyr Pro Asp Ser 
                85          

<210>  1188
<211>  601
<212>  DNA
<213>  Homo sapiens

<400>  1188
gacagtgtca ggatcgcggg cttgctttcc ggtagcgtgg gctgacgcct cgctcaattt     60

ctcacagggc tgcgcaggtt tcccccgtct gcgaatggac cactggaggg gttcaaaggt    120

tcgcgtccca gtacgggaat gagcctcttt gatctcttcc ggggcttttt cggctttcct    180

ggacctcgga gccacagaga tccctttttt ggagggatga ctcgagatga agatgatgat    240

gaggaagaag aagaagaagg gggctcatgg ggccgtggga acccaaggtt ccatagtcct    300

cagcaccccc ctgaggaatt tggcttcggc ttcagcttca gcccaggagg agggatacgt    360

ttccacgata acttcggctt tgatgaccta gtacgagatt tcaatagcat cttcagcgat    420

atgggggcct ggaccttgcc ttcccatcct cctgaacttc caggtcctga gtcagagaca    480

cctggtgaga gactacggga gggacagaca cttcgggact caatgcttaa gtatccagat    540

agtcaccagc ccaggtttcc caggagggtc ttggcccggt tctacagccc cagcccaaat    600

c                                                                    601


<210>  1189
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  1189


Met Ser Leu Phe Asp Leu Phe Arg Gly Phe Phe Gly Phe Pro Gly Pro 
1               5                   10                  15      


Arg Ser His Arg Asp Pro Phe Phe Gly Gly Met Thr Arg Asp Glu Asp 
            20                  25                  30          


Asp Asp Glu Glu Glu Glu Glu Glu Gly Gly Ser Trp Gly Arg Gly Asn 
        35                  40                  45              


Pro Arg Phe His Ser Pro Gln His Pro Pro Glu Glu Phe Gly Phe Gly 
    50                  55                  60                  


Phe Ser Phe Ser Pro Gly Gly Gly Ile Arg Phe His Asp Asn Phe Gly 
65                  70                  75                  80  


Phe Asp Asp Leu Val Arg Asp Phe Asn Ser Ile Phe Ser Asp Met Gly 
                85                  90                  95      


Ala Trp Thr Leu Pro Ser His Pro Pro Glu Leu Pro Gly Pro Glu Ser 
            100                 105                 110         


Glu Thr Pro Gly Glu Arg Leu Arg Glu Gly Gln Thr Leu Arg Asp Ser 
        115                 120                 125             


Met Leu Lys Tyr Pro Asp Ser His Gln Pro Arg Phe Pro Arg Arg Val 
    130                 135                 140                 


Leu Ala Arg Phe Tyr Ser Pro Ser Pro 
145                 150             

<210>  1190
<211>  889
<212>  DNA
<213>  Homo sapiens

<400>  1190
gacagtgtca ggatcgcggg cttgctttcc ggtagcgtgg gctgacgcct cgctcaattt     60

ctcacagggc tgcgcaggtt tcccccgtct gcgaatggac cactggaggg gttcaaaggt    120

tcgcgtccca gtacgggaat gagcctcttt gatctcttcc ggggcttttt cggctttcct    180

ggacctcgga gaacttccag gtcctgagtc agagacacct ggtgagagac tacgggaggg    240

acagacactt cgggactcaa tgcttaagta tccagatagt caccagccca ggatctttgg    300

gggggtcttg gagagtgatg caagaagtga atccccccaa ccagcaccag actggggctc    360

ccagaggcca tttcataggt ttgatgatgt atggcctatg gacccccatc ctagaaccag    420

agaggacaat gatcttgatt cccaggtttc ccaggagggt cttggcccgg ttctacagcc    480

ccagcccaaa tcctatttca agagcatctc tgtgaccaag atcactaaac cagatgggat    540

agtggaggag cgccggactg tggtggacag tgagggccgg acagagacta cagtaacccg    600

acacgaagca gatagcagtc ctaggggtga tccagaatca ccaagacctc cagccctgga    660

tgatgccttt tccatcctgg acttattcct gggacgttgg ttccggtccc ggtagccttg    720

ttaaccctca gaggccttca agtcctttcc acctctcacc cattgcccac cattaataag    780

cttagcttct cttgccacct caggggcttg gatatgtgga atagtgaact ggggccatgt    840

cagtttgtca ctcacccaaa ctgaccaata aaacctttat ttatgctaa                889


<210>  1191
<211>  151
<212>  PRT
<213>  Homo sapiens

<400>  1191


Met Leu Lys Tyr Pro Asp Ser His Gln Pro Arg Ile Phe Gly Gly Val 
1               5                   10                  15      


Leu Glu Ser Asp Ala Arg Ser Glu Ser Pro Gln Pro Ala Pro Asp Trp 
            20                  25                  30          


Gly Ser Gln Arg Pro Phe His Arg Phe Asp Asp Val Trp Pro Met Asp 
        35                  40                  45              


Pro His Pro Arg Thr Arg Glu Asp Asn Asp Leu Asp Ser Gln Val Ser 
    50                  55                  60                  


Gln Glu Gly Leu Gly Pro Val Leu Gln Pro Gln Pro Lys Ser Tyr Phe 
65                  70                  75                  80  


Lys Ser Ile Ser Val Thr Lys Ile Thr Lys Pro Asp Gly Ile Val Glu 
                85                  90                  95      


Glu Arg Arg Thr Val Val Asp Ser Glu Gly Arg Thr Glu Thr Thr Val 
            100                 105                 110         


Thr Arg His Glu Ala Asp Ser Ser Pro Arg Gly Asp Pro Glu Ser Pro 
        115                 120                 125             


Arg Pro Pro Ala Leu Asp Asp Ala Phe Ser Ile Leu Asp Leu Phe Leu 
    130                 135                 140                 


Gly Arg Trp Phe Arg Ser Arg 
145                 150     

<210>  1192
<211>  781
<212>  DNA
<213>  Homo sapiens

<400>  1192
agccacagag atcccttttt tggagggatg actcgagatg aagatgatga tgaggaagaa     60

gaagaagaag ggggctcatg gggccgtggg aacccaaggt tccatagtcc tcagcacccc    120

cctgaggaat ttggcttcgg cttcagcttc agcccaggag gagggatacg tttccacgat    180

aacttcggct ttgatgacct agtacgagat ttcaatagca tcttcagcga tatgggggcc    240

tggaccttgc cttcccatcc tcctgaactt ccaggtcctg agtcagagac acctggtgag    300

agactacggg agggacagac acttcgggac tcaatgctta agtatccaga tagtcaccag    360

cccaggatct ttgggggggt cttggagagt gatgcaagaa gtgaatcccc ccaaccagca    420

ccagactggg atagtggagg agcgccggac tgtggtggac agtgagggcc ggacagagac    480

tacagtaacc cgacacgaag cagatagcag tcctaggggt gatccagaat caccaagacc    540

tccagccctg gatgatgcct tttccatcct ggacttattc ctgggacgtt ggttccggtc    600

ccggtagcct tgttaaccct cagaggcctt caagtccttt ccacctctca cccattgccc    660

accattaata agcttagctt ctcttgccac ctcaggggct tggatatgtg gaatagtgaa    720

ctggggccat gtcagtttgt cactcaccca aactgaccaa taaaaccttt atttatgcta    780

a                                                                    781


<210>  1193
<211>  145
<212>  PRT
<213>  Homo sapiens

<400>  1193


Met Thr Arg Asp Glu Asp Asp Asp Glu Glu Glu Glu Glu Glu Gly Gly 
1               5                   10                  15      


Ser Trp Gly Arg Gly Asn Pro Arg Phe His Ser Pro Gln His Pro Pro 
            20                  25                  30          


Glu Glu Phe Gly Phe Gly Phe Ser Phe Ser Pro Gly Gly Gly Ile Arg 
        35                  40                  45              


Phe His Asp Asn Phe Gly Phe Asp Asp Leu Val Arg Asp Phe Asn Ser 
    50                  55                  60                  


Ile Phe Ser Asp Met Gly Ala Trp Thr Leu Pro Ser His Pro Pro Glu 
65                  70                  75                  80  


Leu Pro Gly Pro Glu Ser Glu Thr Pro Gly Glu Arg Leu Arg Glu Gly 
                85                  90                  95      


Gln Thr Leu Arg Asp Ser Met Leu Lys Tyr Pro Asp Ser His Gln Pro 
            100                 105                 110         


Arg Ile Phe Gly Gly Val Leu Glu Ser Asp Ala Arg Ser Glu Ser Pro 
        115                 120                 125             


Gln Pro Ala Pro Asp Trp Asp Ser Gly Gly Ala Pro Asp Cys Gly Gly 
    130                 135                 140                 


Gln 
145 

<210>  1194
<211>  737
<212>  DNA
<213>  Homo sapiens

<400>  1194
atgatgagga agaagaagaa gaagggggct catggggccg tgggaaccca aggttccata     60

gtcctcagca cccccctgag gaatttggct tcggcttcag cttcagccca ggaggaggga    120

tacgtttcca cgataacttc ggctttgatg acctagtacg agatttcaat agcatcttca    180

ccccccaacc agcaccagac tggggctccc agaggccatt tcataggttt gatgatgtat    240

ggcctatgga cccccatcct agaaccagag aggacaatga tcttgattcc caggtttccc    300

aggagggtct tggcccggtt ctacagcccc agcccaaatc ctatttcaag agcatctctg    360

tgaccaagat cactaaacca gatgggatag tggaggagcg ccggactgtg gtggacagtg    420

agggccggac agagactaca gtaacccgac acgaagcaga tagcagtcct aggggtgatc    480

cagaatcacc aagacctcca gccctggatg atgccttttc catcctggac ttattcctgg    540

gacgttggtt ccggtcccgg tagccttgtt aaccctcaga ggccttcaag tcctttccac    600

ctctcaccca ttgcccacca ttaataagct tagcttctct tgccacctca ggggcttgga    660

tatgtggaat agtgaactgg ggccatgtca gtttgtcact cacccaaact gaccaataaa    720

acctttattt atgctaa                                                   737


<210>  1195
<211>  105
<212>  PRT
<213>  Homo sapiens

<400>  1195


Met Asp Pro His Pro Arg Thr Arg Glu Asp Asn Asp Leu Asp Ser Gln 
1               5                   10                  15      


Val Ser Gln Glu Gly Leu Gly Pro Val Leu Gln Pro Gln Pro Lys Ser 
            20                  25                  30          


Tyr Phe Lys Ser Ile Ser Val Thr Lys Ile Thr Lys Pro Asp Gly Ile 
        35                  40                  45              


Val Glu Glu Arg Arg Thr Val Val Asp Ser Glu Gly Arg Thr Glu Thr 
    50                  55                  60                  


Thr Val Thr Arg His Glu Ala Asp Ser Ser Pro Arg Gly Asp Pro Glu 
65                  70                  75                  80  


Ser Pro Arg Pro Pro Ala Leu Asp Asp Ala Phe Ser Ile Leu Asp Leu 
                85                  90                  95      


Phe Leu Gly Arg Trp Phe Arg Ser Arg 
            100                 105 

<210>  1196
<211>  5765
<212>  DNA
<213>  Homo sapiens

<400>  1196
ctcatcaaca gaaccgggag gaagggctct ggtggggctg gcggtcccct gttctccccg     60

ctcaggtgcg gcgctgtggc aggaagccac cccctcggtc ggccggtgcg cggggctgtt    120

gcgccatccg ctccggcttt cgtaaccgca ccctgggacg gcccagagac gctccagcgc    180

gagttcctca aatgttttcc tgcgttgcca ggaccgtccg ccgctctgag tcatgtgcga    240

gtgggaagtc gcactgacac tgagccgggc cagagggaga ggagccgagc gcggcgcggg    300

gccgagggac tcgcagtgtg tgtagagagc cgggctcctg cggatggggg ctgcccccgg    360

ggcctgagcc cgcctgcccg cccaccgccc cgccccgccc ctgccacccc tgccgcccgg    420

ttcccattag cctgtccgcc tctgcgggac catggagtgg tagccgagga ggaagcatgc    480

tggccgtcgg ctgcgcgctg ctggctgccc tgctggccgc gccgggagcg gcgctggccc    540

caaggcgctg ccctgcgcag gaggtggcga gaggcgtgct gaccagtctg ccaggagaca    600

gcgtgactct gacctgcccg ggggtagagc cggaagacaa tgccactgtt cactgggtgc    660

tcaggaagcc ggctgcaggc tcccacccca gcagatgggc tggcatggga aggaggctgc    720

tgctgaggtc ggtgcagctc cacgactctg gaaactattc atgctaccgg gccggccgcc    780

cagctgggac tgtgcacttg ctggtggatg ttccccccga ggagccccag ctctcctgct    840

tccggaagag ccccctcagc aatgttgttt gtgagtgggg tcctcggagc accccatccc    900

tgacgacaaa ggctgtgctc ttggtgagga agtttcagaa cagtccggcc gaagacttcc    960

aggagccgtg ccagtattcc caggagtccc agaagttctc ctgccagtta gcagtcccgg   1020

agggagacag ctctttctac atagtgtcca tgtgcgtcgc cagtagtgtc gggagcaagt   1080

tcagcaaaac tcaaaccttt cagggttgtg gaatcttgca gcctgatccg cctgccaaca   1140

tcacagtcac tgccgtggcc agaaaccccc gctggctcag tgtcacctgg caagaccccc   1200

actcctggaa ctcatctttc tacagactac ggtttgagct cagatatcgg gctgaacggt   1260

caaagacatt cacaacatgg atggtcaagg acctccagca tcactgtgtc atccacgacg   1320

cctggagcgg cctgaggcac gtggtgcagc ttcgtgccca ggaggagttc gggcaaggcg   1380

agtggagcga gtggagcccg gaggccatgg gcacgccttg gacagaatcc aggagtcctc   1440

cagctgagaa cgaggtgtcc acccccatgc aggcacttac tactaataaa gacgatgata   1500

atattctctt cagagattct gcaaatgcga caagcctccc aggttcaaga agacgtggaa   1560

gctgcgggct ctgaaggaag gcaagacaag catgcatccg ccgtactctt tggggcagct   1620

ggtcccggag aggcctcgac ccaccccagt gcttgttcct ctcatctccc caccggtgtc   1680

ccccagcagc ctggggtctg acaatacctc gagccacaac cgaccagatg ccagggaccc   1740

acggagccct tatgacatca gcaatacaga ctacttcttc cccagatagc tggctgggtg   1800

gcaccagcag cctggaccct gtggatgata aaacacaaac gggctcagca aaagatgctt   1860

ctcactgcca tgccagctta tctcaggggt gtgcggcctt tggcttcacg gaagagcctt   1920

gcggaaggtt ctacgccagg ggaaaatcag cctgctccag ctgttcagct ggttgaggtt   1980

tcaaacctcc ctttccaaat gcccagctta aaggggctag agtgaacttg ggccactgtg   2040

aagagaacca tatcaagact ctttggacac tcacacggac actcaaaagc tgggcaggtt   2100

ggtgggggcc tcggtgtgga gaagcggctg gcagcccacc cctcaacacc tctgcacaag   2160

ctgcaccctc aggcaggtgg gatggatttc cagccaaagc ctcctccagc cgccatgctc   2220

ctggcccact gcatcgtttc atcttccaac tcaaactctt aaaacccaag tgccttagca   2280

aattctgttt ttctaggcct ggggacggct tttacttaaa ccgccaaggc tgggggaaga   2340

agctctctcc tccctttctt ccctacagtt gaaaaacagc tgagggtgag tgggtgaata   2400

atacagtatc tcagggcctg gtcgttttca acagaattat aattagttcc tcattagcat   2460

tttgctaaat gtgaatgatg atcctaggca tttgctgaat acagaggcaa ctgcattggc   2520

tttgggttgc aggacctcag gtgagaagca gaggaaggag aggagagggg cacagggtct   2580

ctaccatccc ctgtagagtg ggagctgagt gggggatcac agcctctgaa aaccaatgtt   2640

ctctcttctc cacctcccac aaaggagagc tagcagcagg gagggcttct gccatttctg   2700

agatcaaaac ggttttactg cagctttgtt tgttgtcagc tgaacctggg taactaggga   2760

agataatatt aaggaagaca atgtgaaaag aaaaatgagc ctggcaagaa tgtgtttaaa   2820

cttggttttt aaaaaactgc tgactgtttt ctcttgagag ggtggaatat ccaatattcg   2880

ctgtgtcagc atagaagtaa cttacttagg tgtgggggaa gcaccataac tttgtttagc   2940

ccaaaaccaa gtcaagtgaa aaaggaggaa gagaaaaaat attttcctgc caggcatggt   3000

ggcccacgca cttcgggagg tcgaggcagg aggatcactt gagtccagaa gtttgagatc   3060

agcctgggca atgtgataaa accccatctc tacaaaaagc ataaaaatta gccaagtgtg   3120

gtagagtgtg cctgaagtcc cagatacttg gggggctgag gtgggaggat ctcttgagcc   3180

tgggaggtca aggctgcagt gagccgagat tgcaccactg cactccagcc tgggtgacag   3240

agcaagtgag accctgtctc aaaaaaagaa aaagaaaaag aaaaaatatt ttccctatta   3300

gagaagagat tgtggtttca ttctgtattt tgtttttgtc ttaaaaagtg gaaaaatagc   3360

ctgcctcttc tctactctag ggaaaaacca gcgtgtgact actcccccag gtggttatgg   3420

agagggtgtc cggtccctgt cccagtgccg agaaggaagc ctcccacgac tgcccggcag   3480

ggtcctagaa attccccacc ctgaaagccc tgagctttct gctatcaaag aggttttaaa   3540

aaaatcccat ttaaaaaaaa tcccttacct cggtgccttc ctctttttat ttagttcctt   3600

gagttgattc agctctgcaa gaattgaagc aggactaaat gtctagttgt aacaccatga   3660

ttaaccactt cagctgactt ttctgtccga gctttgaaaa ttcagtggtg ttagtggtta   3720

cccagttagc tctcaagtta tcagggtatt ccagagtggg gatatgattt aaatcagccg   3780

tgtaaccatg gacccaatat ttaccagacc acaaaacttt tctaatactc taccctctta   3840

gaaaaaccac caccatcacc agacaggtgc gaaaggatga aagtgaccat gttttgttta   3900

cggttttcca ggtttaagct gttactgtct tcagtaagcc gtgattttca ttgctgggct   3960

tgtctgtaga ttttagaccc tattgctgct tgaggcaact catcttaggt tggcaaaaag   4020

gcaggatggc cgggcgcggt ggctcacgcc tgtaatccta gcactttggg aggccaaggt   4080

gggaggattg cttgagctca ggagtttgag accaacctgg gtaacatagt gagacaccat   4140

ctctattatg aacaataaca gttaagaaaa aaaaaggcag gcaggcggtt atggtggttc   4200

cctcccatcc caccacataa agtttctgag acttgagaac agcaaaatgc tgttaaaggg   4260

aaatattaag aatgagaatc tgcagtaagg gtgattctgt gcccacagtt cttcaattct   4320

ttataccgtt ttacccacat gtggtgttac caaagccggg cagaaccatg ctagcggaag   4380

atgtgaaatc cagatagctc attattgcca agagctaggc agctttgatc tccaaattgt   4440

tattgctttc atttttattg taatggaatt gctttgtttt gtttttttgt ttttgtattg   4500

aagagggttg ttttcccttt atttttcata agctaatgta aatgaagaaa aaatgtcttc   4560

tctgggctgt aggcctggct cagcgtacac aggtatacat cctaagctct ctatgttctc   4620

taatctgtgg tgactgaaca tgtgtctcaa tgcacggggc atttctacct gtgtttctgc   4680

agcaccccca ctgccttgag tccccagcag tgctgttatt tgcctaacac ctgtagccat   4740

ctgccacgca gccagacgtg aaacgctgag acagagacca tttaggttaa atacgacagc   4800

ttatcctgct gggtggggaa agtaaaaaat atgctggttc aaggcctaaa gtaaaatgat   4860

caataatgtt tgtagcatta atgaaatatt ttcaagaaat gtgtccaggg gtagcactgg   4920

ctatgttgac gaggcctttg gtaactcaga gagctcttgg ccctgatggg gacttgccct   4980

tacgctttct ttatcaggct ctgagttcac acggagcctc tggcacttcc ctgctgtctt   5040

gggagaaagg aaactggttg ccgcggcagg ttgtggaatc tgttgctgga accaggctgg   5100

aagcccacct ggtagtgaac agggcccagt ggggcaggct gggcatgttg tggtctatgg   5160

gtttgtttcc tggagaatgt tcaggaatgt cttcccagct gctttggtgc tgagctctat   5220

tatctcacag cacgtccaga aggctaaccc aggtggggag gatgctgaca ccagctccag   5280

gtggagttgg tggtcttaat ttggagatgc aggggcaacc tgtgaccctt tgaggcaaga   5340

gccctgcacc cagctgtccc gtgcagccgt gggcaggggc tgcacacgga ggggcaggcg   5400

ggccagttca gggtccgtgc caggccctcc tcagtgccct gtgaaggcct cctgtcctcc   5460

gtgcggctgg gcaccagcac cagggagttt ctatggcaac cttagtgatt attaaggaac   5520

actgtcagtt ttatgaacat atgctcaaat gaaattctac tttaggagga aaggattgga   5580

acagcatgtc acaaggctgt taattaacag agagacctta ttggatggag atcacatctg   5640

ttaaatagaa tacctcaact ctacgttgtt ttcttggaga taaataatag tttcaagttt   5700

ttgtttgttt gttttaccta attacctgaa agcaaatacc aaaggctgat gtctgtatat   5760

ggggc                                                               5765


<210>  1197
<211>  365
<212>  PRT
<213>  Homo sapiens

<400>  1197


Met Leu Ala Val Gly Cys Ala Leu Leu Ala Ala Leu Leu Ala Ala Pro 
1               5                   10                  15      


Gly Ala Ala Leu Ala Pro Arg Arg Cys Pro Ala Gln Glu Val Ala Arg 
            20                  25                  30          


Gly Val Leu Thr Ser Leu Pro Gly Asp Ser Val Thr Leu Thr Cys Pro 
        35                  40                  45              


Gly Val Glu Pro Glu Asp Asn Ala Thr Val His Trp Val Leu Arg Lys 
    50                  55                  60                  


Pro Ala Ala Gly Ser His Pro Ser Arg Trp Ala Gly Met Gly Arg Arg 
65                  70                  75                  80  


Leu Leu Leu Arg Ser Val Gln Leu His Asp Ser Gly Asn Tyr Ser Cys 
                85                  90                  95      


Tyr Arg Ala Gly Arg Pro Ala Gly Thr Val His Leu Leu Val Asp Val 
            100                 105                 110         


Pro Pro Glu Glu Pro Gln Leu Ser Cys Phe Arg Lys Ser Pro Leu Ser 
        115                 120                 125             


Asn Val Val Cys Glu Trp Gly Pro Arg Ser Thr Pro Ser Leu Thr Thr 
    130                 135                 140                 


Lys Ala Val Leu Leu Val Arg Lys Phe Gln Asn Ser Pro Ala Glu Asp 
145                 150                 155                 160 


Phe Gln Glu Pro Cys Gln Tyr Ser Gln Glu Ser Gln Lys Phe Ser Cys 
                165                 170                 175     


Gln Leu Ala Val Pro Glu Gly Asp Ser Ser Phe Tyr Ile Val Ser Met 
            180                 185                 190         


Cys Val Ala Ser Ser Val Gly Ser Lys Phe Ser Lys Thr Gln Thr Phe 
        195                 200                 205             


Gln Gly Cys Gly Ile Leu Gln Pro Asp Pro Pro Ala Asn Ile Thr Val 
    210                 215                 220                 


Thr Ala Val Ala Arg Asn Pro Arg Trp Leu Ser Val Thr Trp Gln Asp 
225                 230                 235                 240 


Pro His Ser Trp Asn Ser Ser Phe Tyr Arg Leu Arg Phe Glu Leu Arg 
                245                 250                 255     


Tyr Arg Ala Glu Arg Ser Lys Thr Phe Thr Thr Trp Met Val Lys Asp 
            260                 265                 270         


Leu Gln His His Cys Val Ile His Asp Ala Trp Ser Gly Leu Arg His 
        275                 280                 285             


Val Val Gln Leu Arg Ala Gln Glu Glu Phe Gly Gln Gly Glu Trp Ser 
    290                 295                 300                 


Glu Trp Ser Pro Glu Ala Met Gly Thr Pro Trp Thr Glu Ser Arg Ser 
305                 310                 315                 320 


Pro Pro Ala Glu Asn Glu Val Ser Thr Pro Met Gln Ala Leu Thr Thr 
                325                 330                 335     


Asn Lys Asp Asp Asp Asn Ile Leu Phe Arg Asp Ser Ala Asn Ala Thr 
            340                 345                 350         


Ser Leu Pro Gly Ser Arg Arg Arg Gly Ser Cys Gly Leu 
        355                 360                 365 

<210>  1198
<211>  5859
<212>  DNA
<213>  Homo sapiens

<400>  1198
ctcatcaaca gaaccgggag gaagggctct ggtggggctg gcggtcccct gttctccccg     60

ctcaggtgcg gcgctgtggc aggaagccac cccctcggtc ggccggtgcg cggggctgtt    120

gcgccatccg ctccggcttt cgtaaccgca ccctgggacg gcccagagac gctccagcgc    180

gagttcctca aatgttttcc tgcgttgcca ggaccgtccg ccgctctgag tcatgtgcga    240

gtgggaagtc gcactgacac tgagccgggc cagagggaga ggagccgagc gcggcgcggg    300

gccgagggac tcgcagtgtg tgtagagagc cgggctcctg cggatggggg ctgcccccgg    360

ggcctgagcc cgcctgcccg cccaccgccc cgccccgccc ctgccacccc tgccgcccgg    420

ttcccattag cctgtccgcc tctgcgggac catggagtgg tagccgagga ggaagcatgc    480

tggccgtcgg ctgcgcgctg ctggctgccc tgctggccgc gccgggagcg gcgctggccc    540

caaggcgctg ccctgcgcag gaggtggcga gaggcgtgct gaccagtctg ccaggagaca    600

gcgtgactct gacctgcccg ggggtagagc cggaagacaa tgccactgtt cactgggtgc    660

tcaggaagcc ggctgcaggc tcccacccca gcagatgggc tggcatggga aggaggctgc    720

tgctgaggtc ggtgcagctc cacgactctg gaaactattc atgctaccgg gccggccgcc    780

cagctgggac tgtgcacttg ctggtggatg ttccccccga ggagccccag ctctcctgct    840

tccggaagag ccccctcagc aatgttgttt gtgagtgggg tcctcggagc accccatccc    900

tgacgacaaa ggctgtgctc ttggtgagga agtttcagaa cagtccggcc gaagacttcc    960

aggagccgtg ccagtattcc caggagtccc agaagttctc ctgccagtta gcagtcccgg   1020

agggagacag ctctttctac atagtgtcca tgtgcgtcgc cagtagtgtc gggagcaagt   1080

tcagcaaaac tcaaaccttt cagggttgtg gaatcttgca gcctgatccg cctgccaaca   1140

tcacagtcac tgccgtggcc agaaaccccc gctggctcag tgtcacctgg caagaccccc   1200

actcctggaa ctcatctttc tacagactac ggtttgagct cagatatcgg gctgaacggt   1260

caaagacatt cacaacatgg atggtcaagg acctccagca tcactgtgtc atccacgacg   1320

cctggagcgg cctgaggcac gtggtgcagc ttcgtgccca ggaggagttc gggcaaggcg   1380

agtggagcga gtggagcccg gaggccatgg gcacgccttg gacagaatcc aggagtcctc   1440

cagctgagaa cgaggtgtcc acccccatgc aggcacttac tactaataaa gacgatgata   1500

atattctctt cagagattct gcaaatgcga caagcctccc agtgcaagat tcttcttcag   1560

taccactgcc cacattcctg gttgctggag ggagcctggc cttcggaacg ctcctctgca   1620

ttgccattgt tctgaggttc aagaagacgt ggaagctgcg ggctctgaag gaaggcaaga   1680

caagcatgca tccgccgtac tctttggggc agctggtccc ggagaggcct cgacccaccc   1740

cagtgcttgt tcctctcatc tccccaccgg tgtcccccag cagcctgggg tctgacaata   1800

cctcgagcca caaccgacca gatgccaggg acccacggag cccttatgac atcagcaata   1860

cagactactt cttccccaga tagctggctg ggtggcacca gcagcctgga ccctgtggat   1920

gataaaacac aaacgggctc agcaaaagat gcttctcact gccatgccag cttatctcag   1980

gggtgtgcgg cctttggctt cacggaagag ccttgcggaa ggttctacgc caggggaaaa   2040

tcagcctgct ccagctgttc agctggttga ggtttcaaac ctccctttcc aaatgcccag   2100

cttaaagggg ctagagtgaa cttgggccac tgtgaagaga accatatcaa gactctttgg   2160

acactcacac ggacactcaa aagctgggca ggttggtggg ggcctcggtg tggagaagcg   2220

gctggcagcc cacccctcaa cacctctgca caagctgcac cctcaggcag gtgggatgga   2280

tttccagcca aagcctcctc cagccgccat gctcctggcc cactgcatcg tttcatcttc   2340

caactcaaac tcttaaaacc caagtgcctt agcaaattct gtttttctag gcctggggac   2400

ggcttttact taaaccgcca aggctggggg aagaagctct ctcctccctt tcttccctac   2460

agttgaaaaa cagctgaggg tgagtgggtg aataatacag tatctcaggg cctggtcgtt   2520

ttcaacagaa ttataattag ttcctcatta gcattttgct aaatgtgaat gatgatccta   2580

ggcatttgct gaatacagag gcaactgcat tggctttggg ttgcaggacc tcaggtgaga   2640

agcagaggaa ggagaggaga ggggcacagg gtctctacca tcccctgtag agtgggagct   2700

gagtggggga tcacagcctc tgaaaaccaa tgttctctct tctccacctc ccacaaagga   2760

gagctagcag cagggagggc ttctgccatt tctgagatca aaacggtttt actgcagctt   2820

tgtttgttgt cagctgaacc tgggtaacta gggaagataa tattaaggaa gacaatgtga   2880

aaagaaaaat gagcctggca agaatgtgtt taaacttggt ttttaaaaaa ctgctgactg   2940

ttttctcttg agagggtgga atatccaata ttcgctgtgt cagcatagaa gtaacttact   3000

taggtgtggg ggaagcacca taactttgtt tagcccaaaa ccaagtcaag tgaaaaagga   3060

ggaagagaaa aaatattttc ctgccaggca tggtggccca cgcacttcgg gaggtcgagg   3120

caggaggatc acttgagtcc agaagtttga gatcagcctg ggcaatgtga taaaacccca   3180

tctctacaaa aagcataaaa attagccaag tgtggtagag tgtgcctgaa gtcccagata   3240

cttggggggc tgaggtggga ggatctcttg agcctgggag gtcaaggctg cagtgagccg   3300

agattgcacc actgcactcc agcctgggtg acagagcaag tgagaccctg tctcaaaaaa   3360

agaaaaagaa aaagaaaaaa tattttccct attagagaag agattgtggt ttcattctgt   3420

attttgtttt tgtcttaaaa agtggaaaaa tagcctgcct cttctctact ctagggaaaa   3480

accagcgtgt gactactccc ccaggtggtt atggagaggg tgtccggtcc ctgtcccagt   3540

gccgagaagg aagcctccca cgactgcccg gcagggtcct agaaattccc caccctgaaa   3600

gccctgagct ttctgctatc aaagaggttt taaaaaaatc ccatttaaaa aaaatccctt   3660

acctcggtgc cttcctcttt ttatttagtt ccttgagttg attcagctct gcaagaattg   3720

aagcaggact aaatgtctag ttgtaacacc atgattaacc acttcagctg acttttctgt   3780

ccgagctttg aaaattcagt ggtgttagtg gttacccagt tagctctcaa gttatcaggg   3840

tattccagag tggggatatg atttaaatca gccgtgtaac catggaccca atatttacca   3900

gaccacaaaa cttttctaat actctaccct cttagaaaaa ccaccaccat caccagacag   3960

gtgcgaaagg atgaaagtga ccatgttttg tttacggttt tccaggttta agctgttact   4020

gtcttcagta agccgtgatt ttcattgctg ggcttgtctg tagattttag accctattgc   4080

tgcttgaggc aactcatctt aggttggcaa aaaggcagga tggccgggcg cggtggctca   4140

cgcctgtaat cctagcactt tgggaggcca aggtgggagg attgcttgag ctcaggagtt   4200

tgagaccaac ctgggtaaca tagtgagaca ccatctctat tatgaacaat aacagttaag   4260

aaaaaaaaag gcaggcaggc ggttatggtg gttccctccc atcccaccac ataaagtttc   4320

tgagacttga gaacagcaaa atgctgttaa agggaaatat taagaatgag aatctgcagt   4380

aagggtgatt ctgtgcccac agttcttcaa ttctttatac cgttttaccc acatgtggtg   4440

ttaccaaagc cgggcagaac catgctagcg gaagatgtga aatccagata gctcattatt   4500

gccaagagct aggcagcttt gatctccaaa ttgttattgc tttcattttt attgtaatgg   4560

aattgctttg ttttgttttt ttgtttttgt attgaagagg gttgttttcc ctttattttt   4620

cataagctaa tgtaaatgaa gaaaaaatgt cttctctggg ctgtaggcct ggctcagcgt   4680

acacaggtat acatcctaag ctctctatgt tctctaatct gtggtgactg aacatgtgtc   4740

tcaatgcacg gggcatttct acctgtgttt ctgcagcacc cccactgcct tgagtcccca   4800

gcagtgctgt tatttgccta acacctgtag ccatctgcca cgcagccaga cgtgaaacgc   4860

tgagacagag accatttagg ttaaatacga cagcttatcc tgctgggtgg ggaaagtaaa   4920

aaatatgctg gttcaaggcc taaagtaaaa tgatcaataa tgtttgtagc attaatgaaa   4980

tattttcaag aaatgtgtcc aggggtagca ctggctatgt tgacgaggcc tttggtaact   5040

cagagagctc ttggccctga tggggacttg cccttacgct ttctttatca ggctctgagt   5100

tcacacggag cctctggcac ttccctgctg tcttgggaga aaggaaactg gttgccgcgg   5160

caggttgtgg aatctgttgc tggaaccagg ctggaagccc acctggtagt gaacagggcc   5220

cagtggggca ggctgggcat gttgtggtct atgggtttgt ttcctggaga atgttcagga   5280

atgtcttccc agctgctttg gtgctgagct ctattatctc acagcacgtc cagaaggcta   5340

acccaggtgg ggaggatgct gacaccagct ccaggtggag ttggtggtct taatttggag   5400

atgcaggggc aacctgtgac cctttgaggc aagagccctg cacccagctg tcccgtgcag   5460

ccgtgggcag gggctgcaca cggaggggca ggcgggccag ttcagggtcc gtgccaggcc   5520

ctcctcagtg ccctgtgaag gcctcctgtc ctccgtgcgg ctgggcacca gcaccaggga   5580

gtttctatgg caaccttagt gattattaag gaacactgtc agttttatga acatatgctc   5640

aaatgaaatt ctactttagg aggaaaggat tggaacagca tgtcacaagg ctgttaatta   5700

acagagagac cttattggat ggagatcaca tctgttaaat agaatacctc aactctacgt   5760

tgttttcttg gagataaata atagtttcaa gtttttgttt gtttgtttta cctaattacc   5820

tgaaagcaaa taccaaaggc tgatgtctgt atatggggc                          5859


<210>  1199
<211>  468
<212>  PRT
<213>  Homo sapiens

<400>  1199


Met Leu Ala Val Gly Cys Ala Leu Leu Ala Ala Leu Leu Ala Ala Pro 
1               5                   10                  15      


Gly Ala Ala Leu Ala Pro Arg Arg Cys Pro Ala Gln Glu Val Ala Arg 
            20                  25                  30          


Gly Val Leu Thr Ser Leu Pro Gly Asp Ser Val Thr Leu Thr Cys Pro 
        35                  40                  45              


Gly Val Glu Pro Glu Asp Asn Ala Thr Val His Trp Val Leu Arg Lys 
    50                  55                  60                  


Pro Ala Ala Gly Ser His Pro Ser Arg Trp Ala Gly Met Gly Arg Arg 
65                  70                  75                  80  


Leu Leu Leu Arg Ser Val Gln Leu His Asp Ser Gly Asn Tyr Ser Cys 
                85                  90                  95      


Tyr Arg Ala Gly Arg Pro Ala Gly Thr Val His Leu Leu Val Asp Val 
            100                 105                 110         


Pro Pro Glu Glu Pro Gln Leu Ser Cys Phe Arg Lys Ser Pro Leu Ser 
        115                 120                 125             


Asn Val Val Cys Glu Trp Gly Pro Arg Ser Thr Pro Ser Leu Thr Thr 
    130                 135                 140                 


Lys Ala Val Leu Leu Val Arg Lys Phe Gln Asn Ser Pro Ala Glu Asp 
145                 150                 155                 160 


Phe Gln Glu Pro Cys Gln Tyr Ser Gln Glu Ser Gln Lys Phe Ser Cys 
                165                 170                 175     


Gln Leu Ala Val Pro Glu Gly Asp Ser Ser Phe Tyr Ile Val Ser Met 
            180                 185                 190         


Cys Val Ala Ser Ser Val Gly Ser Lys Phe Ser Lys Thr Gln Thr Phe 
        195                 200                 205             


Gln Gly Cys Gly Ile Leu Gln Pro Asp Pro Pro Ala Asn Ile Thr Val 
    210                 215                 220                 


Thr Ala Val Ala Arg Asn Pro Arg Trp Leu Ser Val Thr Trp Gln Asp 
225                 230                 235                 240 


Pro His Ser Trp Asn Ser Ser Phe Tyr Arg Leu Arg Phe Glu Leu Arg 
                245                 250                 255     


Tyr Arg Ala Glu Arg Ser Lys Thr Phe Thr Thr Trp Met Val Lys Asp 
            260                 265                 270         


Leu Gln His His Cys Val Ile His Asp Ala Trp Ser Gly Leu Arg His 
        275                 280                 285             


Val Val Gln Leu Arg Ala Gln Glu Glu Phe Gly Gln Gly Glu Trp Ser 
    290                 295                 300                 


Glu Trp Ser Pro Glu Ala Met Gly Thr Pro Trp Thr Glu Ser Arg Ser 
305                 310                 315                 320 


Pro Pro Ala Glu Asn Glu Val Ser Thr Pro Met Gln Ala Leu Thr Thr 
                325                 330                 335     


Asn Lys Asp Asp Asp Asn Ile Leu Phe Arg Asp Ser Ala Asn Ala Thr 
            340                 345                 350         


Ser Leu Pro Val Gln Asp Ser Ser Ser Val Pro Leu Pro Thr Phe Leu 
        355                 360                 365             


Val Ala Gly Gly Ser Leu Ala Phe Gly Thr Leu Leu Cys Ile Ala Ile 
    370                 375                 380                 


Val Leu Arg Phe Lys Lys Thr Trp Lys Leu Arg Ala Leu Lys Glu Gly 
385                 390                 395                 400 


Lys Thr Ser Met His Pro Pro Tyr Ser Leu Gly Gln Leu Val Pro Glu 
                405                 410                 415     


Arg Pro Arg Pro Thr Pro Val Leu Val Pro Leu Ile Ser Pro Pro Val 
            420                 425                 430         


Ser Pro Ser Ser Leu Gly Ser Asp Asn Thr Ser Ser His Asn Arg Pro 
        435                 440                 445             


Asp Ala Arg Asp Pro Arg Ser Pro Tyr Asp Ile Ser Asn Thr Asp Tyr 
    450                 455                 460                 


Phe Phe Pro Arg 
465             

<210>  1200
<211>  5854
<212>  DNA
<213>  Homo sapiens

<400>  1200
ctcatcaaca gaaccgggag gaagggctct ggtggggctg gcggtcccct gttctccccg     60

ctcaggtgcg gcgctgtggc aggaagccac cccctcggtc ggccggtgcg cggggctgtt    120

gcgccatccg ctccggcttt cgtaaccgca ccctgggacg gcccagagac gctccagcgc    180

gagttcctca aatgttttcc tgcgttgcca ggaccgtccg ccgctctgag tcatgtgcga    240

gtgggaagtc gcactgacac tgagccgggc cagagggaga ggagccgagc gcggcgcggg    300

gccgagggac tcgcagtgtg tgtagagagc cgggctcctg cggatggggg ctgcccccgg    360

ggcctgagcc cgcctgcccg cccaccgccc cgccccgccc ctgccacccc tgccgcccgg    420

ttcccattag cctgtccgcc tctgcgggac catggagtgg tagccgagga ggaagcatgc    480

tggccgtcgg ctgcgcgctg ctggctgccc tgctggccgc gccgggagcg gcgctggccc    540

caaggcgctg ccctgcgcag gaggtggcga gaggcgtgct gaccagtctg ccaggagaca    600

gcgtgactct gacctgcccg ggggtagagc cggaagacaa tgccactgtt cactgggtgc    660

tcaggaagcc ggctgcaggc tcccacccca gcagatgggc tggcatggga aggaggctgc    720

tgctgaggtc ggtgcagctc cacgactctg gaaactattc atgctaccgg gccggccgcc    780

cagctgggac tgtgcacttg ctggtggatg ttccccccga ggagccccag ctctcctgct    840

tccggaagag ccccctcagc aatgttgttt gtgagtgggg tcctcggagc accccatccc    900

tgacgacaaa ggctgtgctc ttggtgagga agtttcagaa cagtccggcc gaagacttcc    960

aggagccgtg ccagtattcc caggagtccc agaagttctc ctgccagtta gcagtcccgg   1020

agggagacag ctctttctac atagtgtcca tgtgcgtcgc cagtagtgtc gggagcaagt   1080

tcagcaaaac tcaaaccttt cagggttgtg gaatcttgca gcctgatccg cctgccaaca   1140

tcacagtcac tgccgtggcc agaaaccccc gctggctcag tgtcacctgg caagaccccc   1200

actcctggaa ctcatctttc tacagactac ggtttgagct cagatatcgg gctgaacggt   1260

caaagacatt cacaacatgg atggtcaagg acctccagca tcactgtgtc atccacgacg   1320

cctggagcgg cctgaggcac gtggtgcagc ttcgtgccca ggaggagttc gggcaaggcg   1380

agtggagcga gtggagcccg gaggccatgg gcacgccttg gacagaatcc aggagtcctc   1440

cagctgagaa cgaggtgtcc acccccatgc aggcacttac tactaataaa gacgatgata   1500

atattctctt cagagattct gcaaatgcga caagcctccc aggttcaaga agacgtggaa   1560

gctgcgggct ctgaaggaag gcaagacaag catgcatccg ccgtactctt tggggcagct   1620

ggtcccggag aggcctcgac ccaccccagt gcttgttcct ctcatctccc caccggtgtc   1680

ccccagcagc ctggggtctg acaatacctc gagccacaac cgaccagatg ccagggaccc   1740

acggagccct tatgacatca gcaatacaga ctacttcttc cccagatagc tggctgggtg   1800

gcaccagcag cctggaccct gtggatgata aaacacaaac gggctcagca aaagatgctt   1860

ctcactgcca tgccagctta tctcaggggt gtgcggcctt tggcttcacg gaagagcctt   1920

gcggaaggtt ctacgccagg ggaaaatcag cctgctccag ctgttcagct ggttgaggtt   1980

tcaaacctcc ctttccaaat gcccagctta aaggggctag agtgaacttg ggccactgtg   2040

aagagaacca tatcaagact ctttggacac tcacacggac actcaaaagc tgggcaggtt   2100

ggtgggggcc tcggtgtgga gaagcggctg gcagcccacc cctcaacacc tctgcacaag   2160

ctgcaccctc aggcaggtgg gatggatttc cagccaaagc ctcctccagc cgccatgctc   2220

ctggcccact gcatcgtttc atcttccaac tcaaactctt aaaacccaag tgccttagca   2280

aattctgttt ttctaggcct ggggacggct tttacttaaa ccgccaaggc tgggggaaga   2340

agctctctcc tccctttctt ccctacagtt gaaaaacagc tgagggtgag tgggtgaata   2400

atacagtatc tcagggcctg gtcgttttca acagaattat aattagttcc tcattagcat   2460

tttgctaaat gtgaatgatg atcctaggca tttgctgaat acagaggcaa ctgcattggc   2520

tttgggttgc aggacctcag gtgagaagca gaggaaggag aggagagggg cacagggtct   2580

ctaccatccc ctgtagagtg ggagctgagt gggggatcac agcctctgaa aaccaatgtt   2640

ctctcttctc cacctcccac aaaggagagc tagcagcagg gagggcttct gccatttctg   2700

agatcaaaac ggttttactg cagctttgtt tgttgtcagc tgaacctggg taactaggga   2760

agataatatt aaggaagaca atgtgaaaag aaaaatgagc ctggcaagaa tgtgtttaaa   2820

cttggttttt aaaaaactgc tgactgtttt ctcttgagag ggtggaatat ccaatattcg   2880

ctgtgtcagc atagaagtaa cttacttagg tgtgggggaa gcaccataac tttgtttagc   2940

ccaaaaccaa gtcaagtgaa aaaggaggaa gagaaaaaat attttcctgc caggcatggt   3000

ggcccacgca cttcgggagg tcgaggcagg aggatcactt gagtccagaa gtttgagatc   3060

agcctgggca atgtgataaa accccatctc tacaaaaagc ataaaaatta gccaagtgtg   3120

gtagagtgtg cctgaagtcc cagatacttg gggggctgag gtgggaggat ctcttgagcc   3180

tgggaggtca aggctgcagt gagccgagat tgcaccactg cactccagcc tgggtgacag   3240

agcaagtgag accctgtctc aaaaaaagaa aaagaaaaag aaaaaatatt ttccctatta   3300

gagaagagat tgtggtttca ttctgtattt tgtttttgtc ttaaaaagtg gaaaaatagc   3360

ctgcctcttc tctactctag ggaaaaacca gcgtgtgact actcccccag gtggttatgg   3420

agagggtgtc cggtccctgt cccagtgccg agaaggaagc ctcccacgac tgcccggcag   3480

ggtcctagaa attccccacc ctgaaagccc tgagctttct gctatcaaag aggttttaaa   3540

aaaatcccat ttaaaaaaaa tcccttacct cggtgccttc ctctttttat ttagttcctt   3600

gagttgattc agctctgcaa gaattgaagc aggactaaat gtctagttgt aacaccatga   3660

ttaaccactt cagctgactt ttctgtccga gctttgaaaa ttcagtggtg ttagtggtta   3720

cccagttagc tctcaagtta tcagggtatt ccagagtggg gatatgattt aaatcagccg   3780

tgtaaccatg gacccaatat ttaccagacc acaaaacttt tctaatactc taccctctta   3840

gaaaaaccac caccatcacc agacaggtgc gaaaggatga aagtgaccat gttttgttta   3900

cggttttcca ggtttaagct gttactgtct tcagtaagcc gtgattttca ttgctgggct   3960

tgtctgtaga ttttagaccc tattgctgct tgaggcaact catcttaggt tggcaaaaag   4020

gcaggatggc cgggcgcggt ggctcacgcc tgtaatccta gcactttggg aggccaaggt   4080

gggaggattg cttgagctca ggagtttgag accaacctgg gtaacatagt gagacaccat   4140

ctctattatg aacaataaca gttaagaaaa aaaaaggcag gcaggcggtt atggtggttc   4200

cctcccatcc caccacataa agtttctgag acttgagaac agcaaaatgc tgttaaaggg   4260

aaatattaag aatgagaatc tgcagtaagg gtgattctgt gcccacagtt cttcaattct   4320

ttataccgtt ttacccacat gtggtgttac caaagccggg cagaaccatg ctagcggaag   4380

atgtgaaatc cagatagctc attattgcca agagctaggc agctttgatc tccaaattgt   4440

tattgctttc atttttattg taatggaatt gctttgtttt gtttttttgt ttttgtattg   4500

aagagggttg ttttcccttt atttttcata agctaatgta aatgaagaaa aaatgtcttc   4560

tctgggctgt aggcctggct cagcgtacac aggtatacat cctaagctct ctatgttctc   4620

taatctgtgg tgactgaaca tgtgtctcaa tgcacggggc atttctacct gtgtttctgc   4680

agcaccccca ctgccttgag tccccagcag tgctgttatt tgcctaacac ctgtagccat   4740

ctgccacgca gccagacgtg aaacgctgag acagagacca tttaggttaa atacgacagc   4800

ttatcctgct gggtggggaa agtaaaaaat atgctggttc aaggcctaaa gtaaaatgat   4860

caataatgtt tgtagcatta atgaaatatt ttcaagaaat gtgtccaggg gtagcactgg   4920

ctatgttgac gaggcctttg gtaactcaga gagctcttgg ccctgatggg gacttgccct   4980

tacgctttct ttatcaggct ctgagttcac acggagcctc tggcacttcc ctgctgtctt   5040

gggagaaagg aaactggttg ccgcggcagg ttgtggaatc tgttgctgga accaggctgg   5100

aagcccacct ggtagtgaac agggcccagt ggggcaggct gggcatgttg tggtctatgg   5160

gtttgtttcc tggagaatgt tcaggaatgt cttcccagct gctttggtgc tgagctctat   5220

tatctcacag cacgtccaga aggctaaccc aggtggggag gatgctgaca ccagctccag   5280

gtggagttgg tggtcttaat ttggagatgc aggggcaacc tgtgaccctt tgaggcaaga   5340

gccctgcacc cagctgtccc gtgcagccgt gggcaggggc tgcacacgga ggggcaggcg   5400

ggccagttca gggtccgtgc caggccctcc tcagtgccct gtgaaggcct cctgtcctcc   5460

gtgcggctgg gcaccagcac cagggagttt ctatggcaac cttagtgatt attaaggaac   5520

actgtcagtt ttatgaacat atgctcaaat gaaattctac tttaggagga aaggattgga   5580

acagcatgtc acaaggctgt taattaacag agagacctta ttggatggag atcacatctg   5640

ttaaatagaa tacctcaact ctacgttgtt ttcttggaga taaataatag tttcaagttt   5700

ttgtttgttt gttttaccta attacctgaa agcaaatacc aaaggctgat gtctgtatat   5760

ggggcaaagg gtcagtatat ttttcagtgt ttttttttct accagctatt ttgcatttaa   5820

agtgaacatt gtgtttggaa taaatactct taaa                               5854


<210>  1201
<211>  365
<212>  PRT
<213>  Homo sapiens

<400>  1201


Met Leu Ala Val Gly Cys Ala Leu Leu Ala Ala Leu Leu Ala Ala Pro 
1               5                   10                  15      


Gly Ala Ala Leu Ala Pro Arg Arg Cys Pro Ala Gln Glu Val Ala Arg 
            20                  25                  30          


Gly Val Leu Thr Ser Leu Pro Gly Asp Ser Val Thr Leu Thr Cys Pro 
        35                  40                  45              


Gly Val Glu Pro Glu Asp Asn Ala Thr Val His Trp Val Leu Arg Lys 
    50                  55                  60                  


Pro Ala Ala Gly Ser His Pro Ser Arg Trp Ala Gly Met Gly Arg Arg 
65                  70                  75                  80  


Leu Leu Leu Arg Ser Val Gln Leu His Asp Ser Gly Asn Tyr Ser Cys 
                85                  90                  95      


Tyr Arg Ala Gly Arg Pro Ala Gly Thr Val His Leu Leu Val Asp Val 
            100                 105                 110         


Pro Pro Glu Glu Pro Gln Leu Ser Cys Phe Arg Lys Ser Pro Leu Ser 
        115                 120                 125             


Asn Val Val Cys Glu Trp Gly Pro Arg Ser Thr Pro Ser Leu Thr Thr 
    130                 135                 140                 


Lys Ala Val Leu Leu Val Arg Lys Phe Gln Asn Ser Pro Ala Glu Asp 
145                 150                 155                 160 


Phe Gln Glu Pro Cys Gln Tyr Ser Gln Glu Ser Gln Lys Phe Ser Cys 
                165                 170                 175     


Gln Leu Ala Val Pro Glu Gly Asp Ser Ser Phe Tyr Ile Val Ser Met 
            180                 185                 190         


Cys Val Ala Ser Ser Val Gly Ser Lys Phe Ser Lys Thr Gln Thr Phe 
        195                 200                 205             


Gln Gly Cys Gly Ile Leu Gln Pro Asp Pro Pro Ala Asn Ile Thr Val 
    210                 215                 220                 


Thr Ala Val Ala Arg Asn Pro Arg Trp Leu Ser Val Thr Trp Gln Asp 
225                 230                 235                 240 


Pro His Ser Trp Asn Ser Ser Phe Tyr Arg Leu Arg Phe Glu Leu Arg 
                245                 250                 255     


Tyr Arg Ala Glu Arg Ser Lys Thr Phe Thr Thr Trp Met Val Lys Asp 
            260                 265                 270         


Leu Gln His His Cys Val Ile His Asp Ala Trp Ser Gly Leu Arg His 
        275                 280                 285             


Val Val Gln Leu Arg Ala Gln Glu Glu Phe Gly Gln Gly Glu Trp Ser 
    290                 295                 300                 


Glu Trp Ser Pro Glu Ala Met Gly Thr Pro Trp Thr Glu Ser Arg Ser 
305                 310                 315                 320 


Pro Pro Ala Glu Asn Glu Val Ser Thr Pro Met Gln Ala Leu Thr Thr 
                325                 330                 335     


Asn Lys Asp Asp Asp Asn Ile Leu Phe Arg Asp Ser Ala Asn Ala Thr 
            340                 345                 350         


Ser Leu Pro Gly Ser Arg Arg Arg Gly Ser Cys Gly Leu 
        355                 360                 365 

<210>  1202
<211>  5948
<212>  DNA
<213>  Homo sapiens

<400>  1202
ctcatcaaca gaaccgggag gaagggctct ggtggggctg gcggtcccct gttctccccg     60

ctcaggtgcg gcgctgtggc aggaagccac cccctcggtc ggccggtgcg cggggctgtt    120

gcgccatccg ctccggcttt cgtaaccgca ccctgggacg gcccagagac gctccagcgc    180

gagttcctca aatgttttcc tgcgttgcca ggaccgtccg ccgctctgag tcatgtgcga    240

gtgggaagtc gcactgacac tgagccgggc cagagggaga ggagccgagc gcggcgcggg    300

gccgagggac tcgcagtgtg tgtagagagc cgggctcctg cggatggggg ctgcccccgg    360

ggcctgagcc cgcctgcccg cccaccgccc cgccccgccc ctgccacccc tgccgcccgg    420

ttcccattag cctgtccgcc tctgcgggac catggagtgg tagccgagga ggaagcatgc    480

tggccgtcgg ctgcgcgctg ctggctgccc tgctggccgc gccgggagcg gcgctggccc    540

caaggcgctg ccctgcgcag gaggtggcga gaggcgtgct gaccagtctg ccaggagaca    600

gcgtgactct gacctgcccg ggggtagagc cggaagacaa tgccactgtt cactgggtgc    660

tcaggaagcc ggctgcaggc tcccacccca gcagatgggc tggcatggga aggaggctgc    720

tgctgaggtc ggtgcagctc cacgactctg gaaactattc atgctaccgg gccggccgcc    780

cagctgggac tgtgcacttg ctggtggatg ttccccccga ggagccccag ctctcctgct    840

tccggaagag ccccctcagc aatgttgttt gtgagtgggg tcctcggagc accccatccc    900

tgacgacaaa ggctgtgctc ttggtgagga agtttcagaa cagtccggcc gaagacttcc    960

aggagccgtg ccagtattcc caggagtccc agaagttctc ctgccagtta gcagtcccgg   1020

agggagacag ctctttctac atagtgtcca tgtgcgtcgc cagtagtgtc gggagcaagt   1080

tcagcaaaac tcaaaccttt cagggttgtg gaatcttgca gcctgatccg cctgccaaca   1140

tcacagtcac tgccgtggcc agaaaccccc gctggctcag tgtcacctgg caagaccccc   1200

actcctggaa ctcatctttc tacagactac ggtttgagct cagatatcgg gctgaacggt   1260

caaagacatt cacaacatgg atggtcaagg acctccagca tcactgtgtc atccacgacg   1320

cctggagcgg cctgaggcac gtggtgcagc ttcgtgccca ggaggagttc gggcaaggcg   1380

agtggagcga gtggagcccg gaggccatgg gcacgccttg gacagaatcc aggagtcctc   1440

cagctgagaa cgaggtgtcc acccccatgc aggcacttac tactaataaa gacgatgata   1500

atattctctt cagagattct gcaaatgcga caagcctccc agtgcaagat tcttcttcag   1560

taccactgcc cacattcctg gttgctggag ggagcctggc cttcggaacg ctcctctgca   1620

ttgccattgt tctgaggttc aagaagacgt ggaagctgcg ggctctgaag gaaggcaaga   1680

caagcatgca tccgccgtac tctttggggc agctggtccc ggagaggcct cgacccaccc   1740

cagtgcttgt tcctctcatc tccccaccgg tgtcccccag cagcctgggg tctgacaata   1800

cctcgagcca caaccgacca gatgccaggg acccacggag cccttatgac atcagcaata   1860

cagactactt cttccccaga tagctggctg ggtggcacca gcagcctgga ccctgtggat   1920

gataaaacac aaacgggctc agcaaaagat gcttctcact gccatgccag cttatctcag   1980

gggtgtgcgg cctttggctt cacggaagag ccttgcggaa ggttctacgc caggggaaaa   2040

tcagcctgct ccagctgttc agctggttga ggtttcaaac ctccctttcc aaatgcccag   2100

cttaaagggg ctagagtgaa cttgggccac tgtgaagaga accatatcaa gactctttgg   2160

acactcacac ggacactcaa aagctgggca ggttggtggg ggcctcggtg tggagaagcg   2220

gctggcagcc cacccctcaa cacctctgca caagctgcac cctcaggcag gtgggatgga   2280

tttccagcca aagcctcctc cagccgccat gctcctggcc cactgcatcg tttcatcttc   2340

caactcaaac tcttaaaacc caagtgcctt agcaaattct gtttttctag gcctggggac   2400

ggcttttact taaaccgcca aggctggggg aagaagctct ctcctccctt tcttccctac   2460

agttgaaaaa cagctgaggg tgagtgggtg aataatacag tatctcaggg cctggtcgtt   2520

ttcaacagaa ttataattag ttcctcatta gcattttgct aaatgtgaat gatgatccta   2580

ggcatttgct gaatacagag gcaactgcat tggctttggg ttgcaggacc tcaggtgaga   2640

agcagaggaa ggagaggaga ggggcacagg gtctctacca tcccctgtag agtgggagct   2700

gagtggggga tcacagcctc tgaaaaccaa tgttctctct tctccacctc ccacaaagga   2760

gagctagcag cagggagggc ttctgccatt tctgagatca aaacggtttt actgcagctt   2820

tgtttgttgt cagctgaacc tgggtaacta gggaagataa tattaaggaa gacaatgtga   2880

aaagaaaaat gagcctggca agaatgtgtt taaacttggt ttttaaaaaa ctgctgactg   2940

ttttctcttg agagggtgga atatccaata ttcgctgtgt cagcatagaa gtaacttact   3000

taggtgtggg ggaagcacca taactttgtt tagcccaaaa ccaagtcaag tgaaaaagga   3060

ggaagagaaa aaatattttc ctgccaggca tggtggccca cgcacttcgg gaggtcgagg   3120

caggaggatc acttgagtcc agaagtttga gatcagcctg ggcaatgtga taaaacccca   3180

tctctacaaa aagcataaaa attagccaag tgtggtagag tgtgcctgaa gtcccagata   3240

cttggggggc tgaggtggga ggatctcttg agcctgggag gtcaaggctg cagtgagccg   3300

agattgcacc actgcactcc agcctgggtg acagagcaag tgagaccctg tctcaaaaaa   3360

agaaaaagaa aaagaaaaaa tattttccct attagagaag agattgtggt ttcattctgt   3420

attttgtttt tgtcttaaaa agtggaaaaa tagcctgcct cttctctact ctagggaaaa   3480

accagcgtgt gactactccc ccaggtggtt atggagaggg tgtccggtcc ctgtcccagt   3540

gccgagaagg aagcctccca cgactgcccg gcagggtcct agaaattccc caccctgaaa   3600

gccctgagct ttctgctatc aaagaggttt taaaaaaatc ccatttaaaa aaaatccctt   3660

acctcggtgc cttcctcttt ttatttagtt ccttgagttg attcagctct gcaagaattg   3720

aagcaggact aaatgtctag ttgtaacacc atgattaacc acttcagctg acttttctgt   3780

ccgagctttg aaaattcagt ggtgttagtg gttacccagt tagctctcaa gttatcaggg   3840

tattccagag tggggatatg atttaaatca gccgtgtaac catggaccca atatttacca   3900

gaccacaaaa cttttctaat actctaccct cttagaaaaa ccaccaccat caccagacag   3960

gtgcgaaagg atgaaagtga ccatgttttg tttacggttt tccaggttta agctgttact   4020

gtcttcagta agccgtgatt ttcattgctg ggcttgtctg tagattttag accctattgc   4080

tgcttgaggc aactcatctt aggttggcaa aaaggcagga tggccgggcg cggtggctca   4140

cgcctgtaat cctagcactt tgggaggcca aggtgggagg attgcttgag ctcaggagtt   4200

tgagaccaac ctgggtaaca tagtgagaca ccatctctat tatgaacaat aacagttaag   4260

aaaaaaaaag gcaggcaggc ggttatggtg gttccctccc atcccaccac ataaagtttc   4320

tgagacttga gaacagcaaa atgctgttaa agggaaatat taagaatgag aatctgcagt   4380

aagggtgatt ctgtgcccac agttcttcaa ttctttatac cgttttaccc acatgtggtg   4440

ttaccaaagc cgggcagaac catgctagcg gaagatgtga aatccagata gctcattatt   4500

gccaagagct aggcagcttt gatctccaaa ttgttattgc tttcattttt attgtaatgg   4560

aattgctttg ttttgttttt ttgtttttgt attgaagagg gttgttttcc ctttattttt   4620

cataagctaa tgtaaatgaa gaaaaaatgt cttctctggg ctgtaggcct ggctcagcgt   4680

acacaggtat acatcctaag ctctctatgt tctctaatct gtggtgactg aacatgtgtc   4740

tcaatgcacg gggcatttct acctgtgttt ctgcagcacc cccactgcct tgagtcccca   4800

gcagtgctgt tatttgccta acacctgtag ccatctgcca cgcagccaga cgtgaaacgc   4860

tgagacagag accatttagg ttaaatacga cagcttatcc tgctgggtgg ggaaagtaaa   4920

aaatatgctg gttcaaggcc taaagtaaaa tgatcaataa tgtttgtagc attaatgaaa   4980

tattttcaag aaatgtgtcc aggggtagca ctggctatgt tgacgaggcc tttggtaact   5040

cagagagctc ttggccctga tggggacttg cccttacgct ttctttatca ggctctgagt   5100

tcacacggag cctctggcac ttccctgctg tcttgggaga aaggaaactg gttgccgcgg   5160

caggttgtgg aatctgttgc tggaaccagg ctggaagccc acctggtagt gaacagggcc   5220

cagtggggca ggctgggcat gttgtggtct atgggtttgt ttcctggaga atgttcagga   5280

atgtcttccc agctgctttg gtgctgagct ctattatctc acagcacgtc cagaaggcta   5340

acccaggtgg ggaggatgct gacaccagct ccaggtggag ttggtggtct taatttggag   5400

atgcaggggc aacctgtgac cctttgaggc aagagccctg cacccagctg tcccgtgcag   5460

ccgtgggcag gggctgcaca cggaggggca ggcgggccag ttcagggtcc gtgccaggcc   5520

ctcctcagtg ccctgtgaag gcctcctgtc ctccgtgcgg ctgggcacca gcaccaggga   5580

gtttctatgg caaccttagt gattattaag gaacactgtc agttttatga acatatgctc   5640

aaatgaaatt ctactttagg aggaaaggat tggaacagca tgtcacaagg ctgttaatta   5700

acagagagac cttattggat ggagatcaca tctgttaaat agaatacctc aactctacgt   5760

tgttttcttg gagataaata atagtttcaa gtttttgttt gtttgtttta cctaattacc   5820

tgaaagcaaa taccaaaggc tgatgtctgt atatggggca aagggtcagt atatttttca   5880

gtgttttttt ttctaccagc tattttgcat ttaaagtgaa cattgtgttt ggaataaata   5940

ctcttaaa                                                            5948


<210>  1203
<211>  468
<212>  PRT
<213>  Homo sapiens

<400>  1203


Met Leu Ala Val Gly Cys Ala Leu Leu Ala Ala Leu Leu Ala Ala Pro 
1               5                   10                  15      


Gly Ala Ala Leu Ala Pro Arg Arg Cys Pro Ala Gln Glu Val Ala Arg 
            20                  25                  30          


Gly Val Leu Thr Ser Leu Pro Gly Asp Ser Val Thr Leu Thr Cys Pro 
        35                  40                  45              


Gly Val Glu Pro Glu Asp Asn Ala Thr Val His Trp Val Leu Arg Lys 
    50                  55                  60                  


Pro Ala Ala Gly Ser His Pro Ser Arg Trp Ala Gly Met Gly Arg Arg 
65                  70                  75                  80  


Leu Leu Leu Arg Ser Val Gln Leu His Asp Ser Gly Asn Tyr Ser Cys 
                85                  90                  95      


Tyr Arg Ala Gly Arg Pro Ala Gly Thr Val His Leu Leu Val Asp Val 
            100                 105                 110         


Pro Pro Glu Glu Pro Gln Leu Ser Cys Phe Arg Lys Ser Pro Leu Ser 
        115                 120                 125             


Asn Val Val Cys Glu Trp Gly Pro Arg Ser Thr Pro Ser Leu Thr Thr 
    130                 135                 140                 


Lys Ala Val Leu Leu Val Arg Lys Phe Gln Asn Ser Pro Ala Glu Asp 
145                 150                 155                 160 


Phe Gln Glu Pro Cys Gln Tyr Ser Gln Glu Ser Gln Lys Phe Ser Cys 
                165                 170                 175     


Gln Leu Ala Val Pro Glu Gly Asp Ser Ser Phe Tyr Ile Val Ser Met 
            180                 185                 190         


Cys Val Ala Ser Ser Val Gly Ser Lys Phe Ser Lys Thr Gln Thr Phe 
        195                 200                 205             


Gln Gly Cys Gly Ile Leu Gln Pro Asp Pro Pro Ala Asn Ile Thr Val 
    210                 215                 220                 


Thr Ala Val Ala Arg Asn Pro Arg Trp Leu Ser Val Thr Trp Gln Asp 
225                 230                 235                 240 


Pro His Ser Trp Asn Ser Ser Phe Tyr Arg Leu Arg Phe Glu Leu Arg 
                245                 250                 255     


Tyr Arg Ala Glu Arg Ser Lys Thr Phe Thr Thr Trp Met Val Lys Asp 
            260                 265                 270         


Leu Gln His His Cys Val Ile His Asp Ala Trp Ser Gly Leu Arg His 
        275                 280                 285             


Val Val Gln Leu Arg Ala Gln Glu Glu Phe Gly Gln Gly Glu Trp Ser 
    290                 295                 300                 


Glu Trp Ser Pro Glu Ala Met Gly Thr Pro Trp Thr Glu Ser Arg Ser 
305                 310                 315                 320 


Pro Pro Ala Glu Asn Glu Val Ser Thr Pro Met Gln Ala Leu Thr Thr 
                325                 330                 335     


Asn Lys Asp Asp Asp Asn Ile Leu Phe Arg Asp Ser Ala Asn Ala Thr 
            340                 345                 350         


Ser Leu Pro Val Gln Asp Ser Ser Ser Val Pro Leu Pro Thr Phe Leu 
        355                 360                 365             


Val Ala Gly Gly Ser Leu Ala Phe Gly Thr Leu Leu Cys Ile Ala Ile 
    370                 375                 380                 


Val Leu Arg Phe Lys Lys Thr Trp Lys Leu Arg Ala Leu Lys Glu Gly 
385                 390                 395                 400 


Lys Thr Ser Met His Pro Pro Tyr Ser Leu Gly Gln Leu Val Pro Glu 
                405                 410                 415     


Arg Pro Arg Pro Thr Pro Val Leu Val Pro Leu Ile Ser Pro Pro Val 
            420                 425                 430         


Ser Pro Ser Ser Leu Gly Ser Asp Asn Thr Ser Ser His Asn Arg Pro 
        435                 440                 445             


Asp Ala Arg Asp Pro Arg Ser Pro Tyr Asp Ile Ser Asn Thr Asp Tyr 
    450                 455                 460                 


Phe Phe Pro Arg 
465             

<210>  1204
<211>  4735
<212>  DNA
<213>  Homo sapiens

<400>  1204
aaggaactgc catcaaggag gtccccaaag ccttccgttt gttgtaccct ctttgtgcct     60

tgtgggagca ggtggaatgt caccagaaaa gccactctga aagtgagtag gagtctgtgg    120

ctagccacag gcgctcagaa accctgagct tgaggtgtct ctcttgccaa gtggtggaat    180

cctggaatct agagtgggct ttgttaagaa acaaacaaac aaacaaacaa aaaacagtta    240

agcttgtcaa atggcctgtt ggttggcaga gctgtttcat tttctgggag gggggttgga    300

ggggaaggtt cctttgaggc ttttgacagc accagctaag tggttttctt ctcctcctat    360

tcctttttct ccatattctc ctcttcctcc tctatcttca attttttttt taacctagtg    420

caagattctt cttcagtacc actgcccaca ttcctggttg ctggagggag cctggccttc    480

ggaacgctcc tctgcattgc cattgttctg aggttcaaga agacgtggaa gctgcgggct    540

ctgaaggaag gcaagacaag catgcatccg ccgtactctt tggggcagct ggtcccggag    600

aggcctcgac ccaccccagt gcttgttcct ctcatctccc caccggtgtc ccccagcagc    660

ctggggtctg acaatacctc gagccacaac cgaccagatg ccagggaccc acggagccct    720

tatgacatca gcaatacaga ctacttcttc cccagatagc tggctgggtg gcaccagcag    780

cctggaccct gtggatgata aaacacaaac gggctcagca aaagatgctt ctcactgcca    840

tgccagctta tctcaggggt gtgcggcctt tggcttcacg gaagagcctt gcggaaggtt    900

ctacgccagg ggaaaatcag cctgctccag ctgttcagct ggttgaggtt tcaaacctcc    960

ctttccaaat gcccagctta aaggggctag agtgaacttg ggccactgtg aagagaacca   1020

tatcaagact ctttggacac tcacacggac actcaaaagc tgggcaggtt ggtgggggcc   1080

tcggtgtgga gaagcggctg gcagcccacc cctcaacacc tctgcacaag ctgcaccctc   1140

aggcaggtgg gatggatttc cagccaaagc ctcctccagc cgccatgctc ctggcccact   1200

gcatcgtttc atcttccaac tcaaactctt aaaacccaag tgccttagca aattctgttt   1260

ttctaggcct ggggacggct tttacttaaa ccgccaaggc tgggggaaga agctctctcc   1320

tccctttctt ccctacagtt gaaaaacagc tgagggtgag tgggtgaata atacagtatc   1380

tcagggcctg gtcgttttca acagaattat aattagttcc tcattagcat tttgctaaat   1440

gtgaatgatg atcctaggca tttgctgaat acagaggcaa ctgcattggc tttgggttgc   1500

aggacctcag gtgagaagca gaggaaggag aggagagggg cacagggtct ctaccatccc   1560

ctgtagagtg ggagctgagt gggggatcac agcctctgaa aaccaatgtt ctctcttctc   1620

cacctcccac aaaggagagc tagcagcagg gagggcttct gccatttctg agatcaaaac   1680

ggttttactg cagctttgtt tgttgtcagc tgaacctggg taactaggga agataatatt   1740

aaggaagaca atgtgaaaag aaaaatgagc ctggcaagaa tgtgtttaaa cttggttttt   1800

aaaaaactgc tgactgtttt ctcttgagag ggtggaatat ccaatattcg ctgtgtcagc   1860

atagaagtaa cttacttagg tgtgggggaa gcaccataac tttgtttagc ccaaaaccaa   1920

gtcaagtgaa aaaggaggaa gagaaaaaat attttcctgc caggcatggt ggcccacgca   1980

cttcgggagg tcgaggcagg aggatcactt gagtccagaa gtttgagatc agcctgggca   2040

atgtgataaa accccatctc tacaaaaagc ataaaaatta gccaagtgtg gtagagtgtg   2100

cctgaagtcc cagatacttg gggggctgag gtgggaggat ctcttgagcc tgggaggtca   2160

aggctgcagt gagccgagat tgcaccactg cactccagcc tgggtgacag agcaagtgag   2220

accctgtctc aaaaaaagaa aaagaaaaag aaaaaatatt ttccctatta gagaagagat   2280

tgtggtttca ttctgtattt tgtttttgtc ttaaaaagtg gaaaaatagc ctgcctcttc   2340

tctactctag ggaaaaacca gcgtgtgact actcccccag gtggttatgg agagggtgtc   2400

cggtccctgt cccagtgccg agaaggaagc ctcccacgac tgcccggcag ggtcctagaa   2460

attccccacc ctgaaagccc tgagctttct gctatcaaag aggttttaaa aaaatcccat   2520

ttaaaaaaaa tcccttacct cggtgccttc ctctttttat ttagttcctt gagttgattc   2580

agctctgcaa gaattgaagc aggactaaat gtctagttgt aacaccatga ttaaccactt   2640

cagctgactt ttctgtccga gctttgaaaa ttcagtggtg ttagtggtta cccagttagc   2700

tctcaagtta tcagggtatt ccagagtggg gatatgattt aaatcagccg tgtaaccatg   2760

gacccaatat ttaccagacc acaaaacttt tctaatactc taccctctta gaaaaaccac   2820

caccatcacc agacaggtgc gaaaggatga aagtgaccat gttttgttta cggttttcca   2880

ggtttaagct gttactgtct tcagtaagcc gtgattttca ttgctgggct tgtctgtaga   2940

ttttagaccc tattgctgct tgaggcaact catcttaggt tggcaaaaag gcaggatggc   3000

cgggcgcggt ggctcacgcc tgtaatccta gcactttggg aggccaaggt gggaggattg   3060

cttgagctca ggagtttgag accaacctgg gtaacatagt gagacaccat ctctattatg   3120

aacaataaca gttaagaaaa aaaaaggcag gcaggcggtt atggtggttc cctcccatcc   3180

caccacataa agtttctgag acttgagaac agcaaaatgc tgttaaaggg aaatattaag   3240

aatgagaatc tgcagtaagg gtgattctgt gcccacagtt cttcaattct ttataccgtt   3300

ttacccacat gtggtgttac caaagccggg cagaaccatg ctagcggaag atgtgaaatc   3360

cagatagctc attattgcca agagctaggc agctttgatc tccaaattgt tattgctttc   3420

atttttattg taatggaatt gctttgtttt gtttttttgt ttttgtattg aagagggttg   3480

ttttcccttt atttttcata agctaatgta aatgaagaaa aaatgtcttc tctgggctgt   3540

aggcctggct cagcgtacac aggtatacat cctaagctct ctatgttctc taatctgtgg   3600

tgactgaaca tgtgtctcaa tgcacggggc atttctacct gtgtttctgc agcaccccca   3660

ctgccttgag tccccagcag tgctgttatt tgcctaacac ctgtagccat ctgccacgca   3720

gccagacgtg aaacgctgag acagagacca tttaggttaa atacgacagc ttatcctgct   3780

gggtggggaa agtaaaaaat atgctggttc aaggcctaaa gtaaaatgat caataatgtt   3840

tgtagcatta atgaaatatt ttcaagaaat gtgtccaggg gtagcactgg ctatgttgac   3900

gaggcctttg gtaactcaga gagctcttgg ccctgatggg gacttgccct tacgctttct   3960

ttatcaggct ctgagttcac acggagcctc tggcacttcc ctgctgtctt gggagaaagg   4020

aaactggttg ccgcggcagg ttgtggaatc tgttgctgga accaggctgg aagcccacct   4080

ggtagtgaac agggcccagt ggggcaggct gggcatgttg tggtctatgg gtttgtttcc   4140

tggagaatgt tcaggaatgt cttcccagct gctttggtgc tgagctctat tatctcacag   4200

cacgtccaga aggctaaccc aggtggggag gatgctgaca ccagctccag gtggagttgg   4260

tggtcttaat ttggagatgc aggggcaacc tgtgaccctt tgaggcaaga gccctgcacc   4320

cagctgtccc gtgcagccgt gggcaggggc tgcacacgga ggggcaggcg ggccagttca   4380

gggtccgtgc caggccctcc tcagtgccct gtgaaggcct cctgtcctcc gtgcggctgg   4440

gcaccagcac cagggagttt ctatggcaac cttagtgatt attaaggaac actgtcagtt   4500

ttatgaacat atgctcaaat gaaattctac tttaggagga aaggattgga acagcatgtc   4560

acaaggctgt taattaacag agagacctta ttggatggag atcacatctg ttaaatagaa   4620

tacctcaact ctacgttgtt ttcttggaga taaataatag tttcaagttt ttgtttgttt   4680

gttttaccta attacctgaa agcaaatacc aaaggctgat gtctgtatat ggggc        4735


<210>  1205
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  1205


Met Phe Val Ala Leu Met Lys Tyr Phe Gln Glu Met Cys Pro Gly Val 
1               5                   10                  15      


Ala Leu Ala Met Leu Thr Arg Pro Leu Val Thr Gln Arg Ala Leu Gly 
            20                  25                  30          


Pro Asp Gly Asp Leu Pro Leu Arg Phe Leu Tyr Gln Ala Leu Ser Ser 
        35                  40                  45              


His Gly Ala Ser Gly Thr Ser Leu Leu Ser Trp Glu Lys Gly Asn Trp 
    50                  55                  60                  


Leu Pro Arg Gln Val Val Glu Ser Val Ala Gly Thr Arg Leu Glu Ala 
65                  70                  75                  80  


His Leu Val Val Asn Arg Ala Gln Trp Gly Arg Leu Gly Met Leu Trp 
                85                  90                  95      


Ser Met Gly Leu Phe Pro Gly Glu Cys Ser Gly Met Ser Ser Gln Leu 
            100                 105                 110         


Leu Trp Cys 
        115 

<210>  1206
<211>  4824
<212>  DNA
<213>  Homo sapiens

<400>  1206
aaggaactgc catcaaggag gtccccaaag ccttccgttt gttgtaccct ctttgtgcct     60

tgtgggagca ggtggaatgt caccagaaaa gccactctga aagtgagtag gagtctgtgg    120

ctagccacag gcgctcagaa accctgagct tgaggtgtct ctcttgccaa gtggtggaat    180

cctggaatct agagtgggct ttgttaagaa acaaacaaac aaacaaacaa aaaacagtta    240

agcttgtcaa atggcctgtt ggttggcaga gctgtttcat tttctgggag gggggttgga    300

ggggaaggtt cctttgaggc ttttgacagc accagctaag tggttttctt ctcctcctat    360

tcctttttct ccatattctc ctcttcctcc tctatcttca attttttttt taacctagtg    420

caagattctt cttcagtacc actgcccaca ttcctggttg ctggagggag cctggccttc    480

ggaacgctcc tctgcattgc cattgttctg aggttcaaga agacgtggaa gctgcgggct    540

ctgaaggaag gcaagacaag catgcatccg ccgtactctt tggggcagct ggtcccggag    600

aggcctcgac ccaccccagt gcttgttcct ctcatctccc caccggtgtc ccccagcagc    660

ctggggtctg acaatacctc gagccacaac cgaccagatg ccagggaccc acggagccct    720

tatgacatca gcaatacaga ctacttcttc cccagatagc tggctgggtg gcaccagcag    780

cctggaccct gtggatgata aaacacaaac gggctcagca aaagatgctt ctcactgcca    840

tgccagctta tctcaggggt gtgcggcctt tggcttcacg gaagagcctt gcggaaggtt    900

ctacgccagg ggaaaatcag cctgctccag ctgttcagct ggttgaggtt tcaaacctcc    960

ctttccaaat gcccagctta aaggggctag agtgaacttg ggccactgtg aagagaacca   1020

tatcaagact ctttggacac tcacacggac actcaaaagc tgggcaggtt ggtgggggcc   1080

tcggtgtgga gaagcggctg gcagcccacc cctcaacacc tctgcacaag ctgcaccctc   1140

aggcaggtgg gatggatttc cagccaaagc ctcctccagc cgccatgctc ctggcccact   1200

gcatcgtttc atcttccaac tcaaactctt aaaacccaag tgccttagca aattctgttt   1260

ttctaggcct ggggacggct tttacttaaa ccgccaaggc tgggggaaga agctctctcc   1320

tccctttctt ccctacagtt gaaaaacagc tgagggtgag tgggtgaata atacagtatc   1380

tcagggcctg gtcgttttca acagaattat aattagttcc tcattagcat tttgctaaat   1440

gtgaatgatg atcctaggca tttgctgaat acagaggcaa ctgcattggc tttgggttgc   1500

aggacctcag gtgagaagca gaggaaggag aggagagggg cacagggtct ctaccatccc   1560

ctgtagagtg ggagctgagt gggggatcac agcctctgaa aaccaatgtt ctctcttctc   1620

cacctcccac aaaggagagc tagcagcagg gagggcttct gccatttctg agatcaaaac   1680

ggttttactg cagctttgtt tgttgtcagc tgaacctggg taactaggga agataatatt   1740

aaggaagaca atgtgaaaag aaaaatgagc ctggcaagaa tgtgtttaaa cttggttttt   1800

aaaaaactgc tgactgtttt ctcttgagag ggtggaatat ccaatattcg ctgtgtcagc   1860

atagaagtaa cttacttagg tgtgggggaa gcaccataac tttgtttagc ccaaaaccaa   1920

gtcaagtgaa aaaggaggaa gagaaaaaat attttcctgc caggcatggt ggcccacgca   1980

cttcgggagg tcgaggcagg aggatcactt gagtccagaa gtttgagatc agcctgggca   2040

atgtgataaa accccatctc tacaaaaagc ataaaaatta gccaagtgtg gtagagtgtg   2100

cctgaagtcc cagatacttg gggggctgag gtgggaggat ctcttgagcc tgggaggtca   2160

aggctgcagt gagccgagat tgcaccactg cactccagcc tgggtgacag agcaagtgag   2220

accctgtctc aaaaaaagaa aaagaaaaag aaaaaatatt ttccctatta gagaagagat   2280

tgtggtttca ttctgtattt tgtttttgtc ttaaaaagtg gaaaaatagc ctgcctcttc   2340

tctactctag ggaaaaacca gcgtgtgact actcccccag gtggttatgg agagggtgtc   2400

cggtccctgt cccagtgccg agaaggaagc ctcccacgac tgcccggcag ggtcctagaa   2460

attccccacc ctgaaagccc tgagctttct gctatcaaag aggttttaaa aaaatcccat   2520

ttaaaaaaaa tcccttacct cggtgccttc ctctttttat ttagttcctt gagttgattc   2580

agctctgcaa gaattgaagc aggactaaat gtctagttgt aacaccatga ttaaccactt   2640

cagctgactt ttctgtccga gctttgaaaa ttcagtggtg ttagtggtta cccagttagc   2700

tctcaagtta tcagggtatt ccagagtggg gatatgattt aaatcagccg tgtaaccatg   2760

gacccaatat ttaccagacc acaaaacttt tctaatactc taccctctta gaaaaaccac   2820

caccatcacc agacaggtgc gaaaggatga aagtgaccat gttttgttta cggttttcca   2880

ggtttaagct gttactgtct tcagtaagcc gtgattttca ttgctgggct tgtctgtaga   2940

ttttagaccc tattgctgct tgaggcaact catcttaggt tggcaaaaag gcaggatggc   3000

cgggcgcggt ggctcacgcc tgtaatccta gcactttggg aggccaaggt gggaggattg   3060

cttgagctca ggagtttgag accaacctgg gtaacatagt gagacaccat ctctattatg   3120

aacaataaca gttaagaaaa aaaaaggcag gcaggcggtt atggtggttc cctcccatcc   3180

caccacataa agtttctgag acttgagaac agcaaaatgc tgttaaaggg aaatattaag   3240

aatgagaatc tgcagtaagg gtgattctgt gcccacagtt cttcaattct ttataccgtt   3300

ttacccacat gtggtgttac caaagccggg cagaaccatg ctagcggaag atgtgaaatc   3360

cagatagctc attattgcca agagctaggc agctttgatc tccaaattgt tattgctttc   3420

atttttattg taatggaatt gctttgtttt gtttttttgt ttttgtattg aagagggttg   3480

ttttcccttt atttttcata agctaatgta aatgaagaaa aaatgtcttc tctgggctgt   3540

aggcctggct cagcgtacac aggtatacat cctaagctct ctatgttctc taatctgtgg   3600

tgactgaaca tgtgtctcaa tgcacggggc atttctacct gtgtttctgc agcaccccca   3660

ctgccttgag tccccagcag tgctgttatt tgcctaacac ctgtagccat ctgccacgca   3720

gccagacgtg aaacgctgag acagagacca tttaggttaa atacgacagc ttatcctgct   3780

gggtggggaa agtaaaaaat atgctggttc aaggcctaaa gtaaaatgat caataatgtt   3840

tgtagcatta atgaaatatt ttcaagaaat gtgtccaggg gtagcactgg ctatgttgac   3900

gaggcctttg gtaactcaga gagctcttgg ccctgatggg gacttgccct tacgctttct   3960

ttatcaggct ctgagttcac acggagcctc tggcacttcc ctgctgtctt gggagaaagg   4020

aaactggttg ccgcggcagg ttgtggaatc tgttgctgga accaggctgg aagcccacct   4080

ggtagtgaac agggcccagt ggggcaggct gggcatgttg tggtctatgg gtttgtttcc   4140

tggagaatgt tcaggaatgt cttcccagct gctttggtgc tgagctctat tatctcacag   4200

cacgtccaga aggctaaccc aggtggggag gatgctgaca ccagctccag gtggagttgg   4260

tggtcttaat ttggagatgc aggggcaacc tgtgaccctt tgaggcaaga gccctgcacc   4320

cagctgtccc gtgcagccgt gggcaggggc tgcacacgga ggggcaggcg ggccagttca   4380

gggtccgtgc caggccctcc tcagtgccct gtgaaggcct cctgtcctcc gtgcggctgg   4440

gcaccagcac cagggagttt ctatggcaac cttagtgatt attaaggaac actgtcagtt   4500

ttatgaacat atgctcaaat gaaattctac tttaggagga aaggattgga acagcatgtc   4560

acaaggctgt taattaacag agagacctta ttggatggag atcacatctg ttaaatagaa   4620

tacctcaact ctacgttgtt ttcttggaga taaataatag tttcaagttt ttgtttgttt   4680

gttttaccta attacctgaa agcaaatacc aaaggctgat gtctgtatat ggggcaaagg   4740

gtcagtatat ttttcagtgt ttttttttct accagctatt ttgcatttaa agtgaacatt   4800

gtgtttggaa taaatactct taaa                                          4824


<210>  1207
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  1207


Met Phe Val Ala Leu Met Lys Tyr Phe Gln Glu Met Cys Pro Gly Val 
1               5                   10                  15      


Ala Leu Ala Met Leu Thr Arg Pro Leu Val Thr Gln Arg Ala Leu Gly 
            20                  25                  30          


Pro Asp Gly Asp Leu Pro Leu Arg Phe Leu Tyr Gln Ala Leu Ser Ser 
        35                  40                  45              


His Gly Ala Ser Gly Thr Ser Leu Leu Ser Trp Glu Lys Gly Asn Trp 
    50                  55                  60                  


Leu Pro Arg Gln Val Val Glu Ser Val Ala Gly Thr Arg Leu Glu Ala 
65                  70                  75                  80  


His Leu Val Val Asn Arg Ala Gln Trp Gly Arg Leu Gly Met Leu Trp 
                85                  90                  95      


Ser Met Gly Leu Phe Pro Gly Glu Cys Ser Gly Met Ser Ser Gln Leu 
            100                 105                 110         


Leu Trp Cys 
        115 

<210>  1208
<211>  6448
<212>  DNA
<213>  Homo sapiens

<400>  1208
ggcctctccc accgcaggag gaaagagcag ggggaagccc ccggcgcccg ccgcctccga     60

gagccacggt gtcctcgggc cgggcaggcg ttgaagacga gcccgggcgg ggccccccgc    120

gcgtcgtgcc tgtcgcctgc cgtgtccgga gcagaggcta gcgcccgccc gctcggcgcc    180

ccgagccgtg agaaccccac cctgccgggc gtgggcgacg gccggccggg ggcgcacgga    240

gcagccgtcg cggggcctcg ccgcggcctc cagcgcccca gtcacgggga atgcagtggt    300

ccccgacccc tggcgcctct gcgtgtctgg gctgggcttc ctcgctcgcc tgctccacgg    360

ccccgacgct cctgggccga gccggccggg gccccctcat ggcggccaag tggttcaagg    420

agttccccct gaacctgaag accgtgtcgg agcgggccaa gcccgggggc ggcggcggca    480

aattgcgcaa gaactcggag gcgggcggcg ctgggccggg tcctggcaag ggccgcaaga    540

actcggcggc cgagctgggg agcggcaggg ccggcgtcgg ccccaaggac agccggctgt    600

cccgcgacag cctgcagggt ctgattcagg ccgccgcggg caagggccgc aaaaactccc    660

gggccacgga ggaggagccc caccggggtg caaccaagag ctcgggctgc agcacctaca    720

tcaacaggct catcaaggtg gacactcagg agaagaacgg gaagagcaac taccccagca    780

gcagtagctc cagctccagc tcctcttcct ccgcgtcctc ttccccttcc tccctggggc    840

ccgagctgga caagggcaag attattaagc agcaagagac ggtcatcatt ttagaagact    900

atgctgaccc ttatgatgcc aaacggacaa agggtcaaag ggatgcagag agagtcggag    960

agaacgacgg ttacatggaa ccatatgatg cacagcaaat gataacagaa attagacgac   1020

ggggttccaa agatcccctg gtgaaggctc tccagctgct tgacagtccc tgtgaacccg   1080

cagacggtgg cctgaaatca gagaccttgg ccaaaagacg gagttccaag gacctcctgg   1140

ggaagccgcc acagctatac gacactccct acgagcctgc agaagggggg cccagggcag   1200

aggggaaggc gcggccccca gacagccggc tgcccgagaa cgacgagagg cccgcggcag   1260

agtacgagca gccatgggag tggaagaagg agcagatcgt gcgggctctg tcagtccagt   1320

ttgaaggagc tgagcgacct tccttcaggg aggagacagt gaggcagcac caccggcaga   1380

agagctggac ccagaagatc ctgaagccag ccctctcgga ccacagtgag ggagagaaag   1440

tggacccggg cctgcccctg gagaagcagc cctggtatca tggtgccatc agccgtgctg   1500

aggctgagag tcgactacag ccctgcaaag aagctggtta cctggttcga aatagtgagt   1560

cagggaacag caggtactcc attgccctaa agactagtca aggatgtgtc cacatcatag   1620

tggctcagac caaagacaac aaatacacac tgaatcagac aagcgctgtg tttgacagca   1680

tccctgaagt ggtacactat tattccaatg aaaagttgcc tttcaaaggg gcagaacaca   1740

tgactttact ctacccagtg cacagcaagc ttcactaaga ttcagccact gcaagccctg   1800

ggcctctggc accttcaagg gcatcatcag cgcacaacca gcatctcaga ggacaaggct   1860

ggactagcaa ctgctagaaa atgggagtct tccttgaaaa gtcagagagt gatttgtttt   1920

gttttgtttg agacgaagtc tcgctgtgtt gcccaggctg gagtgcaatg gcgcaatctt   1980

ggctcactgc aacatctgac tcctgggttc aagcagttct tccccatcag cctcccaagt   2040

aggtgggact ataggttcgc accaccactc ccagctaatt tttttttttg tatttttagt   2100

agagatgggg tttcgccgtc ttcgtcaggc tggtctcaaa ctcctgacct caaatgatcc   2160

acccacctca gtctccccga gtgcctggat tacaggcatg agccactgca cccggccaag   2220

tctttggtct taaagtgatt ccatgacact ttgtttgtgg cctgtccctt gtttccttgc   2280

taagtagttc tacaataaga aatcatgatt tagctgttgc ctccagctct ggggtagggt   2340

gttcttttta tggtgtgacc ctcaggaagg ttaagtcagg agttcaggag catcagagtt   2400

ctctagaaat gtgcctactt gttacctgga atacctggtc tctaaacaaa ccaacaaaaa   2460

atccacgtgg cttttccaca tgatggtgca gactggaaga ggatgttata ttggactcgt   2520

tattggggaa atgaatgagc gggagaaaat gtgaatgacg ggcaagaagg tggtctttct   2580

ccctcagaag tcctaattca gctctggagt tcatggaaat ccgcaacttc agagtgtggc   2640

ctaaggatta ttttgttggt cagcctttcc aagaaagtgt gtgttctctc aatctctgtg   2700

gattttctca ttttttagca aatcagtgag ataagcataa ataggaagga agatacccca   2760

ggtttaagaa tcaccaatat cattaggcat tggcatcatt attagaattc tgaattatag   2820

aataaaaggt acaacaaaaa tttcatttct gaattttaaa attctggaaa tttgcaaagc   2880

tccacaactg tttttttact gaattaatta catagaactt cgatgtcttt tgtttcatca   2940

tcattgggca ttttagttgc tatggaataa tttttaattt ttgtctctaa aattagattt   3000

gctttgtagt aaatttttta aaaatgcaac cctaagatct gattatatga actgggtctc   3060

taaagcctac aaagattctc tcgttctgta ccaagcagac tgccttgtac tatacagaag   3120

tgtttgaaaa gacctagagg ttttctctta aataccatta cttaagattc atagtattag   3180

gatctttatg atttatcatg agcttatatc accagtttat ttactgtgaa aaaaaccatg   3240

ggaatggcat actgtgagaa gagtactatg gtgaatggct ccagaattaa aattcagcag   3300

atgtgtctgt attctggggt tggtcatttg ggtctcaaaa ctgccccata tgcaaatgta   3360

ctgactgtca tcaatgaaaa gttaaccttt gtagcttata aatacacaca aaatgttgat   3420

ttggttaatt ttttaggaaa gtataccttt gtagttacta gttacatttg actgtaagat   3480

ttagaggtta gtaaattttt gcttctttat tcagataaga tctcagccaa aaggttgtgt   3540

gatctttgat tttaaaaatt taagaggaac ttttcctcac tggaacacaa tgattttatt   3600

aataaagaat gtaggctggg tgcggtggct catgcacgta atcccaacaa tttgggaggc   3660

tgaggcaggc agatcacgtg aggtcaggag tttgagacca gcctggccaa catggtgaaa   3720

ccctgtctgt agtaaaaata caaaaattag ctgggcacgg tggcgggcac ctgtagttcc   3780

agctgcttgg gaggctgagg cacgagaatc acttgagccc aggaggtgga ggttgcagtg   3840

agccaagatt atgtcactgc actccatcct gggtgacaag agcgaaactc catctcaaaa   3900

aaaaaaaaaa aaaaaagcct ggcctggtgg tggatgcctg tggttccagc tattcgggag   3960

gctgaggtag gtggatcacc tctgctcagg tcaaggctgc agcgagccat gatcgcacca   4020

ttgcactcca gcctgagtga cagagtgaga ccctgtctca acaagcaagc aaacaaaaaa   4080

ccaaaaggaa tgtttttttc agatactgat agaatgtttt cagtgtgtat tggttcattt   4140

actatatctt tagtgtaaga ttttaaaagg ttttttcagc atccattcaa caaatattta   4200

ttatctttat acaaattatt cattgtgtta aacttatttt tagtttaaca ttctagaaat   4260

gaaacgtttt tacttaacct tattctacaa agggaataca gcagttattc taattttaat   4320

aaatgctaaa agctttatac aatttttctt tgtgcactaa atgatttttg gcccataccc   4380

agcaactgtg atgaatgtat aatgaaataa catcttgaaa acaggccaga tacattaagt   4440

atttattgag cttctgtcat atgcccagta ttatgcttct tctatactgt ttctctgtga   4500

caagtcatac tatattcttt atagaattaa aagtagagga gaggcagagt ttacatattg   4560

tccagttgct ttacagttgt acaggaggtt ataagaagaa atatagtaaa ttagtgggaa   4620

gtcagaggtg ggggcgttag tgagctattt tcttcttgag gttgtgacac aagctgacaa   4680

aagccaggga gttcacagct gtgtggtggc acaaagttcc atatgttcta aaaacaatta   4740

ggcccagcag ggtgtcccta atggcttcct tgttaaacct ccatggccag ctgatctgaa   4800

gctctgtgac atgttctctg agctctgaat gctctggctt tttgtcattt tgtcttgaga   4860

caagtatttt cctgtagtcc tcattccttc gagttattcc atctcccagg atattctctg   4920

gtgagaagaa tgtctttcag tgaatttgcc ttgaatttag catccataga gctgtgtcag   4980

tgttcttctt gatcacacct tctttaaaaa aaatacttgc ttgcgatgac tggacaagtt   5040

cagttggtta gtttcaggcc tataagaaga gagagtaaag gaccttgcta tttactttga   5100

taccatagtt gtatctcagg atggcctgca aaccactggc cttgtgtgta tttaagctag   5160

gaataaaata atggagaagt gttaatatgt atacaaaaag gtaaatattg atatatctac   5220

tctctgttgg gggcagaagt gtcattttaa gttattcaaa gcactttctt aagcatttta   5280

gaaagccttt attctttgct gttggaagtc tccgtacttt gcagaattgg tatttgtgta   5340

ctagcctctg ccgcaggatg gggaggtggg caggtagctg ataggggcag ccaggagttt   5400

ttgaggcagg tggtgggaaa ttgtcctaat ttgttaattg gattatgtaa ctctgttact   5460

agtctgttat tggctgttgt tactggatgc atcttgatat tcagaagaat aactgtgagg   5520

cattcttcag ttgcgggtta agtggggtta gtttctgttc tgtcagatgc cctttttcag   5580

tcaaaggtta gccccttgtt tctccctcct tccagggttt agggagtgca gtgatgtcga   5640

tttcatttcc cttccccgca ccccttgaca ctcagcagga ttgcactgaa acccttcaca   5700

gatctctcgt tcactagttg tctcctattt ttccataact agcactagtt tggccttatg   5760

acctggttag aatcactctt ctgtattctc atttccaatt tttgtgcccc actaacgtgg   5820

actagagaaa cttggcctgc tgtgcagtgg gccttctgtt caacttaccc tccaccgctg   5880

accctgtgtg aagagagatg gtgcgttact gccatctaat gggaaaagag aaaactgcag   5940

ttgggaaaag cagctgtgca tttaagggta gggctttctg aaggatttct gatacagtcc   6000

agaaaaggga aaatgatgac acagcagttg ccatcttgaa aaatgccctt tcctgcggaa   6060

agggtgtttt gaagtctaat acaactatca tcacaaggtc cctggactaa ggctggatcg   6120

tgtaatttag aatctcaaat tgtattttaa ttaatatgct ggcaacagaa tcattgaaac   6180

aggcgtctca ttttgtcaag ttcttagccg ttcagtttgt caggggcttt aatattttag   6240

atatcaacta atacatagtt tcaactttta aaaatgtttg aagattgtat gtaatatagg   6300

tgtctatcta tagtgcctta gtaatttaaa tcagaaatat tttataaaac ttctggttgt   6360

tttgcagtag ccaatatagg cttcatgccc tcctgaagat agtttcctct gaaatgtaac   6420

tttaaataaa cattattcca agaaaact                                      6448


<210>  1209
<211>  495
<212>  PRT
<213>  Homo sapiens

<400>  1209


Met Gln Trp Ser Pro Thr Pro Gly Ala Ser Ala Cys Leu Gly Trp Ala 
1               5                   10                  15      


Ser Ser Leu Ala Cys Ser Thr Ala Pro Thr Leu Leu Gly Arg Ala Gly 
            20                  25                  30          


Arg Gly Pro Leu Met Ala Ala Lys Trp Phe Lys Glu Phe Pro Leu Asn 
        35                  40                  45              


Leu Lys Thr Val Ser Glu Arg Ala Lys Pro Gly Gly Gly Gly Gly Lys 
    50                  55                  60                  


Leu Arg Lys Asn Ser Glu Ala Gly Gly Ala Gly Pro Gly Pro Gly Lys 
65                  70                  75                  80  


Gly Arg Lys Asn Ser Ala Ala Glu Leu Gly Ser Gly Arg Ala Gly Val 
                85                  90                  95      


Gly Pro Lys Asp Ser Arg Leu Ser Arg Asp Ser Leu Gln Gly Leu Ile 
            100                 105                 110         


Gln Ala Ala Ala Gly Lys Gly Arg Lys Asn Ser Arg Ala Thr Glu Glu 
        115                 120                 125             


Glu Pro His Arg Gly Ala Thr Lys Ser Ser Gly Cys Ser Thr Tyr Ile 
    130                 135                 140                 


Asn Arg Leu Ile Lys Val Asp Thr Gln Glu Lys Asn Gly Lys Ser Asn 
145                 150                 155                 160 


Tyr Pro Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ala Ser 
                165                 170                 175     


Ser Ser Pro Ser Ser Leu Gly Pro Glu Leu Asp Lys Gly Lys Ile Ile 
            180                 185                 190         


Lys Gln Gln Glu Thr Val Ile Ile Leu Glu Asp Tyr Ala Asp Pro Tyr 
        195                 200                 205             


Asp Ala Lys Arg Thr Lys Gly Gln Arg Asp Ala Glu Arg Val Gly Glu 
    210                 215                 220                 


Asn Asp Gly Tyr Met Glu Pro Tyr Asp Ala Gln Gln Met Ile Thr Glu 
225                 230                 235                 240 


Ile Arg Arg Arg Gly Ser Lys Asp Pro Leu Val Lys Ala Leu Gln Leu 
                245                 250                 255     


Leu Asp Ser Pro Cys Glu Pro Ala Asp Gly Gly Leu Lys Ser Glu Thr 
            260                 265                 270         


Leu Ala Lys Arg Arg Ser Ser Lys Asp Leu Leu Gly Lys Pro Pro Gln 
        275                 280                 285             


Leu Tyr Asp Thr Pro Tyr Glu Pro Ala Glu Gly Gly Pro Arg Ala Glu 
    290                 295                 300                 


Gly Lys Ala Arg Pro Pro Asp Ser Arg Leu Pro Glu Asn Asp Glu Arg 
305                 310                 315                 320 


Pro Ala Ala Glu Tyr Glu Gln Pro Trp Glu Trp Lys Lys Glu Gln Ile 
                325                 330                 335     


Val Arg Ala Leu Ser Val Gln Phe Glu Gly Ala Glu Arg Pro Ser Phe 
            340                 345                 350         


Arg Glu Glu Thr Val Arg Gln His His Arg Gln Lys Ser Trp Thr Gln 
        355                 360                 365             


Lys Ile Leu Lys Pro Ala Leu Ser Asp His Ser Glu Gly Glu Lys Val 
    370                 375                 380                 


Asp Pro Gly Leu Pro Leu Glu Lys Gln Pro Trp Tyr His Gly Ala Ile 
385                 390                 395                 400 


Ser Arg Ala Glu Ala Glu Ser Arg Leu Gln Pro Cys Lys Glu Ala Gly 
                405                 410                 415     


Tyr Leu Val Arg Asn Ser Glu Ser Gly Asn Ser Arg Tyr Ser Ile Ala 
            420                 425                 430         


Leu Lys Thr Ser Gln Gly Cys Val His Ile Ile Val Ala Gln Thr Lys 
        435                 440                 445             


Asp Asn Lys Tyr Thr Leu Asn Gln Thr Ser Ala Val Phe Asp Ser Ile 
    450                 455                 460                 


Pro Glu Val Val His Tyr Tyr Ser Asn Glu Lys Leu Pro Phe Lys Gly 
465                 470                 475                 480 


Ala Glu His Met Thr Leu Leu Tyr Pro Val His Ser Lys Leu His 
                485                 490                 495 

<210>  1210
<211>  885
<212>  DNA
<213>  Homo sapiens

<400>  1210
gatccagcct tagtccaggg accttgtgat gatagttgta ttagacttca aaacaccctt     60

tccgcaggaa agggcatttt tcaagatggc aactgctgtg tcatcatttt cccttttctg    120

gactgtatca gaaatccttc agaaagccct acccttaaat gcacagctgc ttttcccaac    180

tgcagttttc tcttttccca ttagatggca gtaacgcacc atctctcttc acacagggtc    240

agcggtggag ggcctgaaac taaccaactg aacttgtcca gtcatcgcaa gcaagtattt    300

tttttaaaga aggtgtgatc aagaagaaca ctgacacagc tctatggatg ctaaattcaa    360

ggcaaattca ctgaaagaca ttcttctcac cagagaatat cctgggagat ggaataactc    420

gaaggaatga ggactacagg aaaatacttg tctcaagaca aaatgacaaa aagccagagc    480

attcagagct cagagaacat gtcacagagc ttcagatcag ctggccatgg aggtttaaca    540

aggaagccat tagggacacc ctgctgggcc taattgtttt tagaacatat ggaactttgt    600

gccaccacac agctgtgaac tccctggctt ttgtcagctt gtgtcacaac ctcaagaaga    660

aaatagctca ctaacgcccc cacctctgac ttcccactaa tttactatat ttcttcttat    720

aacctcctgt acaactgtaa agcaactgga caatatgtaa actctgcctc tcctctactt    780

ttaattctat aaagaatata gtatgacttg tcacagagaa acagtataga agaagcataa    840

tactgggcat atgacagaag ctcaataaat acttaatgta tctgg                    885


<210>  1211
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  1211


Met Ala Val Thr His His Leu Ser Ser His Arg Val Ser Gly Gly Gly 
1               5                   10                  15      


Pro Glu Thr Asn Gln Leu Asn Leu Ser Ser His Arg Lys Gln Val Phe 
            20                  25                  30          


Phe Leu Lys Lys Val 
        35          

<210>  1212
<211>  1145
<212>  DNA
<213>  Homo sapiens

<400>  1212
ggcctctccc accgcaggag gaaagagcag ggggaagccc ccggcgcccg ccgcctccga     60

gagccacggt gtcctcgggc cgggcaggcg ttgaagacga gcccgggcgg ggccccccgc    120

gcgtcgtgcc tgtcgcctgc cgtgtccgga gcagaggcta gcgcccgccc gctcggcgcc    180

ccgagccgtg agaaccccac cctgccgggc gtgggcgacg gccggccggg ggcgcacgga    240

gcagccgtcg cggggcctcg ccgcggcctc cagcgcccca gtcacgggga atgcagtggt    300

ccccgacccc tggcgcctct gcgtgtctgg gctgggcttc ctcgctcgcc tgctccacgg    360

ccccgacgct cctgggccga gccggccggg gccccctcat ggcggccaag tggttcaagg    420

agttccccct gaacctgaag accgtgtcgg agcgggccaa gcccgggggc ggcggcggca    480

aattgcgcaa gaactcggag gcgggcggcg ctgggccggg tcctggcaag ggccgcaaga    540

actcggcggc cgagctgggg agcggcaggg ccggcgtcgg ccccaaggac agccggctgt    600

cccgcgacag cctgcagggt ctgattcagg ccgccgcggg caagggccgc aaaaactccc    660

gggccacgga ggaggagccc caccggggtg caaccaagag ctcgggctgc agcacctaca    720

tcaacaggct catcaaggtg gacactcagg agaagaacgg gaagagcaac taccccagca    780

gcagtagctc cagctccagc tcctcttcct ccgcgtcctc ttccccttcc tccctggggc    840

ccgagctgga caagggcaag attattaagc agcaagagac ggtcatcatt ttagaagact    900

atgctgaccc ttatgatgcc aaacggacaa agggtcaaag ggatgcagag agagtcggag    960

agaacgacgg ttacatggaa ccatatgatg cacagcaaat gataacaggt ttgtaagcag   1020

gctctacaga atagagactg aaatctcaca ctcagtgagt gttgtaatat agtaaccggt   1080

gtctattggg gaagagggat aaagcaattt acccagatcc tgctgacttg aagaaacaga   1140

aatta                                                               1145


<210>  1213
<211>  241
<212>  PRT
<213>  Homo sapiens

<400>  1213


Met Gln Trp Ser Pro Thr Pro Gly Ala Ser Ala Cys Leu Gly Trp Ala 
1               5                   10                  15      


Ser Ser Leu Ala Cys Ser Thr Ala Pro Thr Leu Leu Gly Arg Ala Gly 
            20                  25                  30          


Arg Gly Pro Leu Met Ala Ala Lys Trp Phe Lys Glu Phe Pro Leu Asn 
        35                  40                  45              


Leu Lys Thr Val Ser Glu Arg Ala Lys Pro Gly Gly Gly Gly Gly Lys 
    50                  55                  60                  


Leu Arg Lys Asn Ser Glu Ala Gly Gly Ala Gly Pro Gly Pro Gly Lys 
65                  70                  75                  80  


Gly Arg Lys Asn Ser Ala Ala Glu Leu Gly Ser Gly Arg Ala Gly Val 
                85                  90                  95      


Gly Pro Lys Asp Ser Arg Leu Ser Arg Asp Ser Leu Gln Gly Leu Ile 
            100                 105                 110         


Gln Ala Ala Ala Gly Lys Gly Arg Lys Asn Ser Arg Ala Thr Glu Glu 
        115                 120                 125             


Glu Pro His Arg Gly Ala Thr Lys Ser Ser Gly Cys Ser Thr Tyr Ile 
    130                 135                 140                 


Asn Arg Leu Ile Lys Val Asp Thr Gln Glu Lys Asn Gly Lys Ser Asn 
145                 150                 155                 160 


Tyr Pro Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ala Ser 
                165                 170                 175     


Ser Ser Pro Ser Ser Leu Gly Pro Glu Leu Asp Lys Gly Lys Ile Ile 
            180                 185                 190         


Lys Gln Gln Glu Thr Val Ile Ile Leu Glu Asp Tyr Ala Asp Pro Tyr 
        195                 200                 205             


Asp Ala Lys Arg Thr Lys Gly Gln Arg Asp Ala Glu Arg Val Gly Glu 
    210                 215                 220                 


Asn Asp Gly Tyr Met Glu Pro Tyr Asp Ala Gln Gln Met Ile Thr Gly 
225                 230                 235                 240 


Leu 
    

<210>  1214
<211>  1014
<212>  DNA
<213>  Homo sapiens

<400>  1214
ggcctctccc accgcaggag gaaagagcag ggggaagccc ccggcgcccg ccgcctccga     60

gagccacggt gtcctcgggc cgggcaggcg ttgaagacga gcccgggcgg ggccccccgc    120

gcgtcgtgcc tgtcgcctgc cgtgtccgga gcagaggcta gcgcccgccc gctcggcgcc    180

ccgagccgtg agaaccccac cctgccgggc gtgggcgacg gccggccggg ggcgcacgga    240

gcagccgtcg cggggcctcg ccgcggcctc cagcgcccca gtcacgggga atgcagtggt    300

ccccgacccc tggcgcctct gcgtgtctgg gctgggcttc ctcgctcgcc tgctccacgg    360

ccccgacgct cctgggccga gccggccggg gccccctcat ggcggccaag tggttcaagg    420

agttccccct gaacctgaag accgtgtcgg agcgggccaa gcccgggggc ggcggcggca    480

aattgcgcaa gaactcggag gcgggcggcg ctgggccggg tcctggcaag ggccgcaaga    540

actcggcggc cgagctgggg agcggcaggg ccggcgtcgg ccccaaggac agccggctgt    600

cccgcgacag cctgcagggt ctgattcagg ccgccgcggg caagggccgc aaaaactccc    660

gggccacgga ggaggagccc caccggggtg caaccaagag ctcgggctgc agcacctaca    720

tcaacaggct catcaaggtg gacactcagg agaagaacgg gaagagcaac taccccagca    780

gcagtagctc cagctccagc tcctcttcct ccgcgtcctc ttccccttcc tccctggggc    840

ccgagctgga caagggcaag attattaagc agcaagagac ggtcatcatt ttagaagact    900

atgctgaccc ttatgatgcc aaacggacaa agggtcaaag ggatgcagag agagtcggag    960

agaacgacgg ttacatggaa ccatatgatg cacagcaaat gataacagaa atta         1014


<210>  1215
<211>  240
<212>  PRT
<213>  Homo sapiens

<400>  1215


Met Gln Trp Ser Pro Thr Pro Gly Ala Ser Ala Cys Leu Gly Trp Ala 
1               5                   10                  15      


Ser Ser Leu Ala Cys Ser Thr Ala Pro Thr Leu Leu Gly Arg Ala Gly 
            20                  25                  30          


Arg Gly Pro Leu Met Ala Ala Lys Trp Phe Lys Glu Phe Pro Leu Asn 
        35                  40                  45              


Leu Lys Thr Val Ser Glu Arg Ala Lys Pro Gly Gly Gly Gly Gly Lys 
    50                  55                  60                  


Leu Arg Lys Asn Ser Glu Ala Gly Gly Ala Gly Pro Gly Pro Gly Lys 
65                  70                  75                  80  


Gly Arg Lys Asn Ser Ala Ala Glu Leu Gly Ser Gly Arg Ala Gly Val 
                85                  90                  95      


Gly Pro Lys Asp Ser Arg Leu Ser Arg Asp Ser Leu Gln Gly Leu Ile 
            100                 105                 110         


Gln Ala Ala Ala Gly Lys Gly Arg Lys Asn Ser Arg Ala Thr Glu Glu 
        115                 120                 125             


Glu Pro His Arg Gly Ala Thr Lys Ser Ser Gly Cys Ser Thr Tyr Ile 
    130                 135                 140                 


Asn Arg Leu Ile Lys Val Asp Thr Gln Glu Lys Asn Gly Lys Ser Asn 
145                 150                 155                 160 


Tyr Pro Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ala Ser 
                165                 170                 175     


Ser Ser Pro Ser Ser Leu Gly Pro Glu Leu Asp Lys Gly Lys Ile Ile 
            180                 185                 190         


Lys Gln Gln Glu Thr Val Ile Ile Leu Glu Asp Tyr Ala Asp Pro Tyr 
        195                 200                 205             


Asp Ala Lys Arg Thr Lys Gly Gln Arg Asp Ala Glu Arg Val Gly Glu 
    210                 215                 220                 


Asn Asp Gly Tyr Met Glu Pro Tyr Asp Ala Gln Gln Met Ile Thr Glu 
225                 230                 235                 240 

<210>  1216
<211>  3332
<212>  DNA
<213>  Homo sapiens

<400>  1216
cgagcggagg ggggggcctg tcccggaggt ggcggcggcg ccatcttggc gaagggggga     60

tcaggaagtg cggaccgcgg cggcggcggc ggcggcggcg gcggcggcgg agcccggagc    120

gcaggccgga ggctcccggc ccgccggccc cggagcggag cggagcggag gatgcagcag    180

ccgcagccgc aggggcagca gcagccgggg ccggggcagc agctgggggg ccagggggcg    240

gcgccggggg ccgggggcgg cccagggggg ggcccggggc cggggccctg cctgaggcga    300

gagctgaagc tgctcgagtc catcttccac cgcggccacg agcgcttccg cattgccagc    360

gcctgcctgg acgagctgag ctgcgagttc ctgctggctg gggccggagg ggccggggcg    420

ggggccgcgc ccggaccgca tctcccccca cgggggtcgg tgcctgggga tcctgtccgc    480

atccactgca acatcacgga gtcataccct gctgtgcccc ccatctggtc ggtggagtct    540

gatgacccta acttggctgc tgtcttggag aggctggtgg acataaagaa agggaatact    600

ctgctattgc agcatctgaa gaggatcatc tccgacctgt gtaaactcta taacctccct    660

cagcatccag atgtggagat gctggatcaa cccttgccag cagagcagtg cacacaggaa    720

gacgtgtctt cagaagatga agatgaggag atgcctgagg acacagaaga cttagatcac    780

tatgaaatga aagaggaaga gccagctgag ggcaagaaat ctgaagatga tggcattgga    840

aaagaaaact tggccatcct agagaaaatt aaaaagaacc agaggcaaga ttacttaaat    900

ggtgcagtgt ctggctcggt gcaggccact gaccggctga tgaaggagct cagggatata    960

taccgatcac agagtttcaa aggcggaaac tatgcagtcg aactcgtgaa tgacagtctg   1020

tatgattgga atgtcaaact cctcaaagtt gaccaggaca gcgctttgca caacgatctc   1080

cagatcctca aagagaaaga aggagccgac ttcattctac ttaacttttc ctttaaagat   1140

aactttccct ttgacccacc atttgtcagg gttgtgtctc cagtcctctc tggagggtat   1200

gttctgggcg gaggggccat ctgcatggaa cttctcacca aacagggctg gagcagtgcc   1260

tactccatag agtcagtgat catgcagatc agtgccacac tggtgaaggg gaaagcacga   1320

gtgcagtttg gagccaacaa atctcaatac agtctgacaa gagcacagca gtcctacaag   1380

tccttggtgc agatccacga aaaaaacggc tggtacacac ccccaaaaga agacggctaa   1440

ccctggagta tcacccttcc tccctcccca ggcaccactg gaccaattac ctttgaatgc   1500

tgtatttgga tctcacgctg cctctgtggt tccctccctc atttttcctg gacgtgatag   1560

ctctgcctat tgcaggacaa tgatggctat tctaaacgct aaggaaaaaa aacaaacaca   1620

gaactgtttc aagtactcaa gactgactta cagaccaacc aaccaccttg ctggaaccct   1680

tgctagcagg cattcttata aaagaaactt tcgagcctcc ttatattgct ggaaactcag   1740

ctgtgctcca gactagagcc tccttaccta tgctatggat ttttaattta ttttctctta   1800

tttcatgtac actgcttttt ttggttacag tgtatgatgg atgtgtatga aaaaaatgta   1860

tctttgggaa aacaattaca gtttgttaat ttgaagatgc tggtcttgac tcatctttat   1920

ttttattcgc acatcccacc ccatcccctg aactacttgg gaggtgggga ggggtacgag   1980

tccactgttg ctttggtaga gatgagaggc cgcattttgc tgctaaagca agagaaactt   2040

ggagctgaag cacacacctg gtctgcccct agatttctcc tcaaggcctc tggagcaacc   2100

agcacttgcc cccttggaat gcagagcctg gcctgccaaa ctacaatgtg gtaggctgaa   2160

acgatggtgt taattcttag gactactttt ctagtcacag atgttttcaa atttctaaga   2220

aaaagaaaat gaggctcaag aggctgcttc gtagaattcc ttttgaatga attgagtggg   2280

gatggggaca cagtctccaa gtgtgtatgt ggtcttttct gatctcagct gtgtggctgc   2340

aactcttcgc tgttcattgg ttcctctcct ggaaagtggc ttctaaccag cactggatgg   2400

tgatcattgg taagctttgc tcacctccct ctctcttgct tcatttggct ttatcaaaaa   2460

gaacagacct agctctgaat ttgtttggct tgggaaatta tggattcttt caagccactc   2520

ccacaaggtg ggtcctacta gaaagggtta gcattttaag gggggttgtt ctatacacct   2580

gtgtccttac cccaggctca ggaactgcca gggagggaag atgaggtggg gagtctgtac   2640

tgagatggaa ctgtcagtgc tgtgttgtat gtacttgctg ttgtaaaagt ttgggcatga   2700

ctttgcatct agcgggtgct gcctgcatct ctttgtctgt aagcttgctc tgggactcag   2760

cctcttagga cctacgatgc cagcagctct cattaacagt gaaatgacag aggccaaaga   2820

tggccaagtg aagacccaag tctcagaaaa cccagacttg ggacaactgc ctgggaacta   2880

ggatgctaga gcagttctgt aatgctttga gacacagcaa ttttcacatt ggccattctt   2940

tcccctcccc tacccctttt cttttgaggg acttttaatg tttgctgctt taggtggatg   3000

gagagtccac cagtcccact caatgctgct ctaactctac ccacacccac ctaattaggg   3060

gtgctaataa aacatgctga ggttgagata aagacgggac ataaggggaa aattcattcc   3120

atagagctga aatctggttt tcaaggcctc tgtggctttc ttctgaactt accaccagcc   3180

ctggctggaa tgtagattgt gtttttagta atgtgtactg tgagctgtct tctgtataat   3240

gtattttgta atgtattttt ctcatctacc aaaggatgaa acaaataaaa ttatttaaat   3300

agtttggctc taataaaatt atttgaagaa ac                                 3332


<210>  1217
<211>  422
<212>  PRT
<213>  Homo sapiens

<400>  1217


Met Gln Gln Pro Gln Pro Gln Gly Gln Gln Gln Pro Gly Pro Gly Gln 
1               5                   10                  15      


Gln Leu Gly Gly Gln Gly Ala Ala Pro Gly Ala Gly Gly Gly Pro Gly 
            20                  25                  30          


Gly Gly Pro Gly Pro Gly Pro Cys Leu Arg Arg Glu Leu Lys Leu Leu 
        35                  40                  45              


Glu Ser Ile Phe His Arg Gly His Glu Arg Phe Arg Ile Ala Ser Ala 
    50                  55                  60                  


Cys Leu Asp Glu Leu Ser Cys Glu Phe Leu Leu Ala Gly Ala Gly Gly 
65                  70                  75                  80  


Ala Gly Ala Gly Ala Ala Pro Gly Pro His Leu Pro Pro Arg Gly Ser 
                85                  90                  95      


Val Pro Gly Asp Pro Val Arg Ile His Cys Asn Ile Thr Glu Ser Tyr 
            100                 105                 110         


Pro Ala Val Pro Pro Ile Trp Ser Val Glu Ser Asp Asp Pro Asn Leu 
        115                 120                 125             


Ala Ala Val Leu Glu Arg Leu Val Asp Ile Lys Lys Gly Asn Thr Leu 
    130                 135                 140                 


Leu Leu Gln His Leu Lys Arg Ile Ile Ser Asp Leu Cys Lys Leu Tyr 
145                 150                 155                 160 


Asn Leu Pro Gln His Pro Asp Val Glu Met Leu Asp Gln Pro Leu Pro 
                165                 170                 175     


Ala Glu Gln Cys Thr Gln Glu Asp Val Ser Ser Glu Asp Glu Asp Glu 
            180                 185                 190         


Glu Met Pro Glu Asp Thr Glu Asp Leu Asp His Tyr Glu Met Lys Glu 
        195                 200                 205             


Glu Glu Pro Ala Glu Gly Lys Lys Ser Glu Asp Asp Gly Ile Gly Lys 
    210                 215                 220                 


Glu Asn Leu Ala Ile Leu Glu Lys Ile Lys Lys Asn Gln Arg Gln Asp 
225                 230                 235                 240 


Tyr Leu Asn Gly Ala Val Ser Gly Ser Val Gln Ala Thr Asp Arg Leu 
                245                 250                 255     


Met Lys Glu Leu Arg Asp Ile Tyr Arg Ser Gln Ser Phe Lys Gly Gly 
            260                 265                 270         


Asn Tyr Ala Val Glu Leu Val Asn Asp Ser Leu Tyr Asp Trp Asn Val 
        275                 280                 285             


Lys Leu Leu Lys Val Asp Gln Asp Ser Ala Leu His Asn Asp Leu Gln 
    290                 295                 300                 


Ile Leu Lys Glu Lys Glu Gly Ala Asp Phe Ile Leu Leu Asn Phe Ser 
305                 310                 315                 320 


Phe Lys Asp Asn Phe Pro Phe Asp Pro Pro Phe Val Arg Val Val Ser 
                325                 330                 335     


Pro Val Leu Ser Gly Gly Tyr Val Leu Gly Gly Gly Ala Ile Cys Met 
            340                 345                 350         


Glu Leu Leu Thr Lys Gln Gly Trp Ser Ser Ala Tyr Ser Ile Glu Ser 
        355                 360                 365             


Val Ile Met Gln Ile Ser Ala Thr Leu Val Lys Gly Lys Ala Arg Val 
    370                 375                 380                 


Gln Phe Gly Ala Asn Lys Ser Gln Tyr Ser Leu Thr Arg Ala Gln Gln 
385                 390                 395                 400 


Ser Tyr Lys Ser Leu Val Gln Ile His Glu Lys Asn Gly Trp Tyr Thr 
                405                 410                 415     


Pro Pro Lys Glu Asp Gly 
            420         

<210>  1218
<211>  1030
<212>  DNA
<213>  Homo sapiens

<400>  1218
gtgcctactc catagagtca gtgatcatgc agatcagtgc cacactggtg aaggggaaag     60

cacgagtgca gtttggagcc aacaaagtaa ggatcctggt cctggggctg gtggggctgg    120

gtggagccaa gtacacttgg ggccactagc aggccaaggc tgccttcttt agaggaatga    180

gcataaggcc cccgggctgg tggcattgga tgagagggcc tagggtgccc acaatggaac    240

aactgtgcct tggcccctag gggcacccct aggacttttg ggaggtttcg ggtctggaaa    300

aggaagacta tgggattatg cctccaaggg acctcgaagg tggagggtac ttagtgtttt    360

actagaccac agtgctggga gctgggactc tggggtctct gggtgacagc ctgcagaagg    420

tgaggggcag taaggccaca gctagccatg gcctgatctg gtggcttcct ctccccagtc    480

tcaatacagt ctgacaagag cacagcagtc ctacaagtcc ttggtgcaga tccacgaaaa    540

aaacggctgg tacacacccc caaaagaaga cggctaaccc tggagtatca cccttcctcc    600

ctccccaggc accactggac caattacctt tgaatgctgt atttggatct cacgctgcct    660

ctgtggttcc ctccctcatt tttcctggac gtgatagctc tgcctattgc aggacaatga    720

tggctattct aaacgctaag gaaaaaaaac aaacacagaa ctgtttcaag tactcaagac    780

tgacttacag accaaccaac caccttgctg gaacccttgc tagcaggcat tcttataaaa    840

gaaactttcg agcctcctta tattgctgga aactcagctg tgctccagac tagagcctcc    900

ttacctatgc tatggatttt taatttattt tctcttattt catgtacact gctttttttg    960

gttacagtgt atgatggatg tgtatgaaaa aaatgtatct ttgggaaaac aattacagtt   1020

tgttaatttg                                                          1030


<210>  1219
<211>  58
<212>  PRT
<213>  Homo sapiens

<400>  1219


Met Met Ala Ile Leu Asn Ala Lys Glu Lys Lys Gln Thr Gln Asn Cys 
1               5                   10                  15      


Phe Lys Tyr Ser Arg Leu Thr Tyr Arg Pro Thr Asn His Leu Ala Gly 
            20                  25                  30          


Thr Leu Ala Ser Arg His Ser Tyr Lys Arg Asn Phe Arg Ala Ser Leu 
        35                  40                  45              


Tyr Cys Trp Lys Leu Ser Cys Ala Pro Asp 
    50                  55              

<210>  1220
<211>  1893
<212>  DNA
<213>  Homo sapiens

<400>  1220
cgagcggagg ggggggcctg tcccggaggt ggcggcggcg ccatcttggc gaagggggga     60

tcaggaagtg cggaccgcgg cggcggcggc ggcggcggcg gcggcggcgg agcccggagc    120

gcaggccgga ggctcccggc ccgccggccc cggagcggag cggagcggag gatgcagcag    180

ccgcagccgc aggggcagca gcagccgggg ccggggcagc agctgggggg ccagggggcg    240

gcgccggggg ccgggggcgg cccagggggg ggcccggggc cggggccctg cctgaggcga    300

gagctgaagc tgctcgagtc catcttccac cgcggccacg agcgcttccg cattgccagc    360

gcctgcctgg acgagctgag ctgcgagttc ctgctggctg gggccggagg ggccggggcg    420

ggggccgcgc ccggaccgca tctcccccca cgggggtcgg tgcctgggga tcctgtccgc    480

atccactgca acatcacgga gtcataccct gctgtgcccc ccatctggtc ggtggagtct    540

gatgacccta acttggctgc tgtcttggag aggctggtgg acataaagaa agggaatact    600

ctgctattgc agcatctgaa gaggatcatc tccgacctgt gtaaactcta taacctccct    660

cagcatccag atgtggagat gctggatcaa cccttgccag cagagcagtg cacacaggaa    720

gacgtgtctt cagaagatga agatgaggag atgcctgagg acacagaaga cttagatcac    780

tatgaaatga aagaggaaga gccagctgag ggcaagaaat ctgaagatga tggcattgga    840

aaagaaaact tggccatcct agagaaaatt aaaaagaacc agaggcaaga ttacttaaat    900

ggtgcagtgt ctggctcggt gcaggccact gaccggctga tgaaggagct cagggatata    960

taccgatcac agagtttcaa aggcggaaac tatgcagtcg aactcgtgaa tgacagtctg   1020

tatgattgga atgtcaaact cctcaaagtt gaccaggaca gcgctttgca caacgatctc   1080

cagatcctca aagagaaaga aggagccgac ttcattctac ttaacttttc ctttaaagat   1140

aactttccct ttgacccacc atttgtcagg gttgtgtctc cagtcctctc tggagggtat   1200

gttctgggcg gaggggccat ctgcatggaa cttctcacca aacagggctg gagcagtgcc   1260

tactccatag agtcagtgat catgcagatc agtgccacac tggtgaaggg gaaagcacga   1320

gtgcagtttg gagccaacaa atctcaatac agtctgacaa gagcacagca gtcctacaag   1380

tccttggtgc agatccacga aaaaaacggc tggtacacac ccccaaaaga agacggctaa   1440

ccctggagta tcacccttcc tccctcccca ggcaccactg gaccaattac ctttgaatgc   1500

tgtatttgga tctcacgctg cctctgtggt tccctccctc atttttcctg gacgtgatag   1560

ctctgcctat tgcaggacaa tgatggctat tctaaacgct aaggaaaaaa aacaaacaca   1620

gaactgtttc aagtactcaa gactgactta cagaccaacc aaccaccttg ctggaaccct   1680

tgctagcagg cattcttata aaagaaactt tcgagcctcc ttatattgct ggaaactcag   1740

ctgtgctcca gactagagcc tccttaccta tgctatggat ttttaattta ttttctctta   1800

tttcatgtac actgcttttt ttggttacag tgtatgatgg atgtgtatga aaaaaatgta   1860

tctttgggaa aacaattaca gtttgttaat ttg                                1893


<210>  1221
<211>  422
<212>  PRT
<213>  Homo sapiens

<400>  1221


Met Gln Gln Pro Gln Pro Gln Gly Gln Gln Gln Pro Gly Pro Gly Gln 
1               5                   10                  15      


Gln Leu Gly Gly Gln Gly Ala Ala Pro Gly Ala Gly Gly Gly Pro Gly 
            20                  25                  30          


Gly Gly Pro Gly Pro Gly Pro Cys Leu Arg Arg Glu Leu Lys Leu Leu 
        35                  40                  45              


Glu Ser Ile Phe His Arg Gly His Glu Arg Phe Arg Ile Ala Ser Ala 
    50                  55                  60                  


Cys Leu Asp Glu Leu Ser Cys Glu Phe Leu Leu Ala Gly Ala Gly Gly 
65                  70                  75                  80  


Ala Gly Ala Gly Ala Ala Pro Gly Pro His Leu Pro Pro Arg Gly Ser 
                85                  90                  95      


Val Pro Gly Asp Pro Val Arg Ile His Cys Asn Ile Thr Glu Ser Tyr 
            100                 105                 110         


Pro Ala Val Pro Pro Ile Trp Ser Val Glu Ser Asp Asp Pro Asn Leu 
        115                 120                 125             


Ala Ala Val Leu Glu Arg Leu Val Asp Ile Lys Lys Gly Asn Thr Leu 
    130                 135                 140                 


Leu Leu Gln His Leu Lys Arg Ile Ile Ser Asp Leu Cys Lys Leu Tyr 
145                 150                 155                 160 


Asn Leu Pro Gln His Pro Asp Val Glu Met Leu Asp Gln Pro Leu Pro 
                165                 170                 175     


Ala Glu Gln Cys Thr Gln Glu Asp Val Ser Ser Glu Asp Glu Asp Glu 
            180                 185                 190         


Glu Met Pro Glu Asp Thr Glu Asp Leu Asp His Tyr Glu Met Lys Glu 
        195                 200                 205             


Glu Glu Pro Ala Glu Gly Lys Lys Ser Glu Asp Asp Gly Ile Gly Lys 
    210                 215                 220                 


Glu Asn Leu Ala Ile Leu Glu Lys Ile Lys Lys Asn Gln Arg Gln Asp 
225                 230                 235                 240 


Tyr Leu Asn Gly Ala Val Ser Gly Ser Val Gln Ala Thr Asp Arg Leu 
                245                 250                 255     


Met Lys Glu Leu Arg Asp Ile Tyr Arg Ser Gln Ser Phe Lys Gly Gly 
            260                 265                 270         


Asn Tyr Ala Val Glu Leu Val Asn Asp Ser Leu Tyr Asp Trp Asn Val 
        275                 280                 285             


Lys Leu Leu Lys Val Asp Gln Asp Ser Ala Leu His Asn Asp Leu Gln 
    290                 295                 300                 


Ile Leu Lys Glu Lys Glu Gly Ala Asp Phe Ile Leu Leu Asn Phe Ser 
305                 310                 315                 320 


Phe Lys Asp Asn Phe Pro Phe Asp Pro Pro Phe Val Arg Val Val Ser 
                325                 330                 335     


Pro Val Leu Ser Gly Gly Tyr Val Leu Gly Gly Gly Ala Ile Cys Met 
            340                 345                 350         


Glu Leu Leu Thr Lys Gln Gly Trp Ser Ser Ala Tyr Ser Ile Glu Ser 
        355                 360                 365             


Val Ile Met Gln Ile Ser Ala Thr Leu Val Lys Gly Lys Ala Arg Val 
    370                 375                 380                 


Gln Phe Gly Ala Asn Lys Ser Gln Tyr Ser Leu Thr Arg Ala Gln Gln 
385                 390                 395                 400 


Ser Tyr Lys Ser Leu Val Gln Ile His Glu Lys Asn Gly Trp Tyr Thr 
                405                 410                 415     


Pro Pro Lys Glu Asp Gly 
            420         

<210>  1222
<211>  551
<212>  DNA
<213>  Homo sapiens

<400>  1222
ctctcagtct gggaaagggg tctgcattag agaccactca ccacctggac cattctacta     60

acacctgttt tttccctcct tccaggaaac tatgcagtcg aactcgtgaa tgacagtctg    120

tatgattgga atgtcaaact cctcaagtga gtggggactc tgggattgga gaggaagttg    180

aggaggagtg tgagtggggc tactgtggtg ggatctccag ggcagcccca tccagcattt    240

tcattcaggg tcccggagcg ggtgtgggca gtggtttcgt ggtctgctgc cagccagggc    300

aggggagccc ttatgaagct cctgaggtgg aaccaggcat ctgagcccag gcttgttgct    360

tcttagagtt gaccaggaca gcgctttgca caacgatctc cagatcctca aagagaaaga    420

aggagccgac ttcattctac ttaacttttc ctttaaataa ggatcctggt cctggggctg    480

gtggggctgg gtggagccaa gtacacttgg ggccactagc aggccaaggc tgccttcttt    540

agaggaatga g                                                         551


<210>  1223
<211>  65
<212>  PRT
<213>  Homo sapiens

<400>  1223


Ala Gln Ala Cys Cys Phe Leu Glu Leu Thr Arg Thr Ala Leu Cys Thr 
1               5                   10                  15      


Thr Ile Ser Arg Ser Ser Lys Arg Lys Lys Glu Pro Thr Ser Phe Tyr 
            20                  25                  30          


Leu Thr Phe Pro Leu Asn Lys Asp Pro Gly Pro Gly Ala Gly Gly Ala 
        35                  40                  45              


Gly Trp Ser Gln Val His Leu Gly Pro Leu Ala Gly Gln Gly Cys Leu 
    50                  55                  60                  


Leu 
65  

<210>  1224
<211>  1104
<212>  DNA
<213>  Homo sapiens

<400>  1224
ttcgattggt tctgccgtgg tagggtgtgc gtgaggtgga agaagggctg ttcctccacg     60

gcacggtgga ggagttctga agtcctaaag ttggggcagg acctgcagca tggtcggaga    120

aggggcaaga ggcccggcgg gaagaagcag caagagtaag acaagtcgtg gaattaaggg    180

aagaagcaga aaagttctag aagaggactg gagaagtaga aggactacag accccatgat    240

gcacatggaa atgggcgtaa atctgcacga cttgttccgg ggcatgcgca tgtgtaagcg    300

cacaataatc tcttaagaat taaagaaacc ttgtaacaaa gaaaagtagt gaagaaaagc    360

cttaaggaaa agagaaggaa tgtgtgtagt ccctctgctt aaggaaaaga tagagggtgg    420

gaagatcttc cttcaacaat ttagatcaac atttgttagg tatatgtggt ttgccaggaa    480

actgcatgtg tgttgtggac catatgtgtt gaagatgcag tgatcaaaaa gacttagtcc    540

cagctattaa ggagatcaca gtttggcagc aaattattat agaatgtgat ggctgttcta    600

acagacatat aaaggaagtg ctatggatgg aagcacagag gaagaagagg ttaatagtgt    660

ctaagaacct agaagggatg aagatgaaaa ttgagatttg aaaggtgaga aagtcattaa    720

gacaaggatg acttaaaggt attccaaact cctaagaaat acagggagtt ttggtggatg    780

cagaatgatt gaggaaggct gtgaaagtct tctcttaaca aaaatctctt tctgtaatgg    840

ttgcttgttt atgggatgag aaactagggg gtcatttgct tgcttaaagc ctctggcttc    900

tcctgatgca acttccaggc cagtctacct tctcttctca aatcccccag cttttgcttc    960

aagtttactt ccagcctggc aaggagtgag tcttctgagc acaaccaccc agtgtccaag   1020

cagggcggga acacctcctt cctcatctct cccacacata ctccttccat acccaccaag   1080

aagaaaggca gccaggaaga gtgg                                          1104


<210>  1225
<211>  68
<212>  PRT
<213>  Homo sapiens

<400>  1225


Met Val Gly Glu Gly Ala Arg Gly Pro Ala Gly Arg Ser Ser Lys Ser 
1               5                   10                  15      


Lys Thr Ser Arg Gly Ile Lys Gly Arg Ser Arg Lys Val Leu Glu Glu 
            20                  25                  30          


Asp Trp Arg Ser Arg Arg Thr Thr Asp Pro Met Met His Met Glu Met 
        35                  40                  45              


Gly Val Asn Leu His Asp Leu Phe Arg Gly Met Arg Met Cys Lys Arg 
    50                  55                  60                  


Thr Ile Ile Ser 
65              

<210>  1226
<211>  5866
<212>  DNA
<213>  Homo sapiens

<400>  1226
ctcctccccc tcaccgtccc aattgtattc cctggaagag cagccggaaa agcctccgcc     60

tgctcatacc aggataggca agaagctggt ttctcctcgc agccggctcc ctgaggccca    120

ggaaccaccg cggcggccgg caccacctgg acccagctcc aggcgggcgc ggcttcagca    180

ccacggacag cgccccaccc gcggccctcc ccccggcggc gcgctccagc cggtgtaggc    240

gaggcagcga gctatgcccg cggcatggcc cggcgctgcg gccccgtggc gctgctcctt    300

ggcttcggcc tcctccggct gtgctcaggg gtgtggggta cggatacaga ggagcggctg    360

gtggagcatc tcctggatcc ttcccgctac aacaagctta tccgcccagc caccaatggc    420

tctgagctgg tgacagtaca gcttatggtg tcactggccc agctcatcag tgtgcatgag    480

cgggagcaga tcatgaccac caatgtctgg ctgacccagg agtgggaaga ttatcgcctc    540

acctggaagc ctgaagagtt tgacaacatg aagaaagttc ggctcccttc caaacacatc    600

tggctcccag atgtggtcct gtacaacaat gctgacggca tgtacgaggt gtccttctat    660

tccaatgccg tggtctccta tgatggcagc atcttctggc tgccgcctgc catctacaag    720

agcgcatgca agattgaagt aaagcacttc ccatttgacc agcagaactg caccatgaag    780

ttccgttcgt ggacctacga ccgcacagag atcgacttgg tgctgaagag tgaggtggcc    840

agcctggacg acttcacacc tagtggtgag tgggacatcg tggcgctgcc gggccggcgc    900

aacgagaacc ccgacgactc tacgtacgtg gacatcacgt atgacttcat cattcgccgc    960

aagccgctct tctacaccat caacctcatc atcccctgtg tgctcatcac ctcgctagcc   1020

atccttgtct tctacctgcc atccgactgt ggcgagaaga tgacgttgtg catctcagtg   1080

ctgctggcgc tcacggtctt cctgctgctc atctccaaga tcgtgcctcc cacctccctc   1140

gacgtgccgc tcgtcggcaa gtacctcatg ttcaccatgg tgcttgtcac cttctccatc   1200

gtcaccagcg tgtgcgtgct caacgtgcac caccgctcgc ccaccacgca caccatggcg   1260

ccctgggtga aggtcgtctt cctggagaag ctgcccgcgc tgctcttcat gcagcagcca   1320

cgccatcatt gcgcccgtca gcgcctgcgc ctgcggcgac gccagcgtga gcgcgagggc   1380

gctggagccc tcttcttccg cgaagcccca ggggccgact cctgcacgtg cttcgtcaac   1440

cgcgcgtcgg tgcaggggtt ggccggggcc ttcggggctg agcctgcacc agtggcgggc   1500

cccgggcgct caggggagcc gtgtggctgt ggcctccggg aggcggtgga cggcgtgcgc   1560

ttcatcgcag accacatgcg gagcgaggac gatgaccaga gcgtgagtga ggactggaag   1620

tacgtcgcca tggtgatcga ccgcctcttc ctctggatct ttgtctttgt ctgtgtcttt   1680

ggcaccatcg gcatgttcct gcagcctctc ttccagaact acaccaccac caccttcctc   1740

cactcagacc actcagcccc cagctccaag tgaggccctt cctcatctcc atgctctttc   1800

accctgccac cctctgctgc acagtagtgt tgggtggagg atggacgagt gagctaccag   1860

gaagaggggc gctgccccca cagatccatc cttttgcttc atctggagtc cctcctcccc   1920

cacgcctcca tccacacaca gcagctccaa cctggaggct ggaccaactg ctttgttttg   1980

gctgctctcc atctcttgta ccagcccagg caatagtgtt gaggagggga gcaaggctgc   2040

taagtggaag acagagatgg cagagccatc caccctgagg agtgatgggc aaggggccag   2100

gaaggggaca ggattgtctg ctgcctccaa gtcatgggag aagaggggta taggacaagg   2160

ggtggaaggg caggagctca caccgcaccg ggctggcctg acacaatggt agctctgaag   2220

ggaggggaag agagaggcct gggtgtgacc tgacacctgc cgctgcttga gtggacagca   2280

gctggactgg gtgggcccca cagtggtcag cgattcctgc caagtagggt ttagccgggc   2340

cccatggtca cagacccctg ggggaggctt ccagctcagt cccacagccc cttgcttcta   2400

agggatccag agacctgctc cagatcctct ttccccactg aagaattctg caccctctgg   2460

acttccctct tcttccttcc tttctcaggc tcaaggtgtg gggggcaagg ctgagtatta   2520

ggggagcttc tgagttctga atctttgggt gacctgcttg gagtctcagg tccaaatact   2580

tgaaatctgt gagaagtcca agttcatggg cttttggaac tggaagaact ttgtacagcc   2640

atggattcca acataagcca tgttgcagat gaagaaactg acccacacgg tgagacaagc   2700

acaggtgggt ctgactcttc ctccctgccc tgagatccat ctgtcgagtg ccctgttttt   2760

tccccacttt gaactgactg gttactctaa ggaagtgaac tgaggatgtt agctttaagc   2820

caacccagcc tctttgtcca cagcagagct gaggtgaaca gctggaaccc tgctacatcc   2880

gtgctgctcc agtctgttct gctcatggct ccatccttct ggctgtcact cttcctcttc   2940

cccttcccaa ccaaacctga gcagctttga agcagaactt gggaaggaca gggctgctgc   3000

tgccagcgac acctcagaaa gcatagcctc ggcttcctgc cccatgtgtc cctggaagct   3060

gtaccctgac tctgcttcca gaggccagca gatggtgggt tacagacggg tcagcctgcc   3120

aagtgcacct gagggacctg acctgacaca agccattttg tccctagagc ccagctggga   3180

ctcctgcttc tctaggcagg gcagagggag gagacacagc acaggcacag agcatgggac   3240

agggaccccc gagtctggat tcaagtcctg gccctgctag taactcatgt gagccagctt   3300

gagcaagtcc cttcatcttg ctagagctca gcttccttgc ctataaaacg taggtggcaa   3360

tgccctcttc ctgaggttgc tgggaggata aggcagtgct tgtgaaaaag tctagcgctg   3420

tacctggcac agagtagatg cttcatgaat gttgagtctg acaggcaact ggagctggtg   3480

agaatggggt cccctgactg tcatgccagc ctccctccca ggcccactct tcccccctct   3540

tccctgagga aaccaagtct cccttatcag gaagagctgg gggagctggg aggaacatta   3600

caggaacacc agagggagtc tagcgggtgg gcaggcttct ctctgcagcc ccctcagcag   3660

tttcattcca ttcctgggct gaacccttgc cctggccctg cctcccttct gggtcagcac   3720

ctcctgacac aggtgtgtgc tcagggaccc caggctctag tcctgtactg gctgtggaag   3780

cctatcactg ggacaggaag ccagtggctg caggagacag gcctcagcgc atctcgtctg   3840

tcaggatggg ctcacggaca ccttttcttg gtagcaggga gtgtctctgc actatggaaa   3900

ctttccctct tctagagcgg attgggagtt gcctgtatta tgcctgaacc ctccttgaac   3960

tcatggtcct ggggaaggcg tcttggaacc agaaacagca acaggaaagg agcctccctc   4020

tgaagggtag gatgccggcc tgaggccctc cctcttggct ctcccagggc ctgggctacc   4080

ccgaggcccc agcagctgct gctgtggctg tacttgcttt taatatttcc catacatggc   4140

tgttgtccaa gttaagtcac caaatggtgc tagaggggat ggcagagagc agcttgtcca   4200

gctcctctcc atgacccggt taacacacga gtaaacaggc ctagagcttg tctgctgttt   4260

gacctctttt aagacccggc tgtgctgcat ctacaaaatg aagatgacag agctagccga   4320

ggtcttcagc aaggaagaaa ggggtcagtg tatatgaaag ggttacctgg gcagtgtcat   4380

tccctccatc tctgtacgca gccctttggg aaccatcaca ataaggaaga ggtgagggca   4440

gaggtgaagg atccactgcc caggcaaggt gctaccatgt ggtgggagag tgtgaaccct   4500

caagtgcact gggaagcttt ggggaaccac agtctcttcc acccttgggt cgtgtgtcgt   4560

cctcttctct tgatgtcagg gaagccccta tgcctccttc ccgtggtggg gctatctctg   4620

cagagaatcg ggtgcccagc ttaatgctgg gcaaggactg gaggaagctc cagatctgga   4680

ggtggcagag atactggatg gaaacctgga gcaagggttt gggaggggaa gtgaggaaac   4740

aggttgagac tatctccatc agagatggca aggccacagg tgatctgaga actatttttg   4800

tctgaaaaga aggcatgcac aggctctctg cttttgacag gtggcgttgc agtgggagga   4860

aggcagcttc ctggcgggga gatagaaata ctagaacagc tggtaccaag ttattgaaaa   4920

tttaaaagca aacaagacac agcagccccc aggtggtgtg ttctactgag gaaggctacg   4980

gcagaggaag ggcaagaccg tttcccccaa tggtcttgaa acggaagagg aaacagggag   5040

ggctctttgg atggtttggg gacctggggc tgtttgtatc ccagtattag ctcctgttac   5100

taagggtctg ctctgcgcca ggtcctcagc atgcgttgtc tttattccgc gtgacaatcc   5160

tatgggaagg ggcctccacc tacgtaacag aaatgcggct cagaaagacc aagtgacagc   5220

tagtgagtag tgctgggcct gaaccccaaa gtccacactc ttgctatagc cgctgaggca   5280

ggcagaagag ctccttggga ggaaagtaag gggcattcaa agccttctct gaatcactcc   5340

ccaagccaga gtagacctgg ttccagttgt cccccccttg tttccgggca gagtcaggca   5400

ggtgtcatac catccctccc cgcccaacca gtgctggcca gactcccatt caccgacctt   5460

gactagacag cgaacagcca ccttttagta ttcatcccaa caggtccagg cggtcagtgt   5520

gatagccacg cagttcctaa gggactgtag gtctaggaat cattaggaca ctcactcagc   5580

caccctcgat gcccccatct tccccacact gcccttggcc tccccgctct gcacgcctgg   5640

agtatttgca ctggtctagc ctactccagg tcagactcat taggaactca agattctcgt   5700

aaagaaagtt gtttccaaag ttgtcttgtc actctatttg ggggttggga gagagcccgt   5760

gggggccagc gttggcgaat acaggaaaaa gggagaatgc tggagaaact ggactcgtga   5820

gagcttaaag acatcacaag aatccaaaga aaaagtgagt ggtgac                  5866


<210>  1227
<211>  502
<212>  PRT
<213>  Homo sapiens

<400>  1227


Met Ala Arg Arg Cys Gly Pro Val Ala Leu Leu Leu Gly Phe Gly Leu 
1               5                   10                  15      


Leu Arg Leu Cys Ser Gly Val Trp Gly Thr Asp Thr Glu Glu Arg Leu 
            20                  25                  30          


Val Glu His Leu Leu Asp Pro Ser Arg Tyr Asn Lys Leu Ile Arg Pro 
        35                  40                  45              


Ala Thr Asn Gly Ser Glu Leu Val Thr Val Gln Leu Met Val Ser Leu 
    50                  55                  60                  


Ala Gln Leu Ile Ser Val His Glu Arg Glu Gln Ile Met Thr Thr Asn 
65                  70                  75                  80  


Val Trp Leu Thr Gln Glu Trp Glu Asp Tyr Arg Leu Thr Trp Lys Pro 
                85                  90                  95      


Glu Glu Phe Asp Asn Met Lys Lys Val Arg Leu Pro Ser Lys His Ile 
            100                 105                 110         


Trp Leu Pro Asp Val Val Leu Tyr Asn Asn Ala Asp Gly Met Tyr Glu 
        115                 120                 125             


Val Ser Phe Tyr Ser Asn Ala Val Val Ser Tyr Asp Gly Ser Ile Phe 
    130                 135                 140                 


Trp Leu Pro Pro Ala Ile Tyr Lys Ser Ala Cys Lys Ile Glu Val Lys 
145                 150                 155                 160 


His Phe Pro Phe Asp Gln Gln Asn Cys Thr Met Lys Phe Arg Ser Trp 
                165                 170                 175     


Thr Tyr Asp Arg Thr Glu Ile Asp Leu Val Leu Lys Ser Glu Val Ala 
            180                 185                 190         


Ser Leu Asp Asp Phe Thr Pro Ser Gly Glu Trp Asp Ile Val Ala Leu 
        195                 200                 205             


Pro Gly Arg Arg Asn Glu Asn Pro Asp Asp Ser Thr Tyr Val Asp Ile 
    210                 215                 220                 


Thr Tyr Asp Phe Ile Ile Arg Arg Lys Pro Leu Phe Tyr Thr Ile Asn 
225                 230                 235                 240 


Leu Ile Ile Pro Cys Val Leu Ile Thr Ser Leu Ala Ile Leu Val Phe 
                245                 250                 255     


Tyr Leu Pro Ser Asp Cys Gly Glu Lys Met Thr Leu Cys Ile Ser Val 
            260                 265                 270         


Leu Leu Ala Leu Thr Val Phe Leu Leu Leu Ile Ser Lys Ile Val Pro 
        275                 280                 285             


Pro Thr Ser Leu Asp Val Pro Leu Val Gly Lys Tyr Leu Met Phe Thr 
    290                 295                 300                 


Met Val Leu Val Thr Phe Ser Ile Val Thr Ser Val Cys Val Leu Asn 
305                 310                 315                 320 


Val His His Arg Ser Pro Thr Thr His Thr Met Ala Pro Trp Val Lys 
                325                 330                 335     


Val Val Phe Leu Glu Lys Leu Pro Ala Leu Leu Phe Met Gln Gln Pro 
            340                 345                 350         


Arg His His Cys Ala Arg Gln Arg Leu Arg Leu Arg Arg Arg Gln Arg 
        355                 360                 365             


Glu Arg Glu Gly Ala Gly Ala Leu Phe Phe Arg Glu Ala Pro Gly Ala 
    370                 375                 380                 


Asp Ser Cys Thr Cys Phe Val Asn Arg Ala Ser Val Gln Gly Leu Ala 
385                 390                 395                 400 


Gly Ala Phe Gly Ala Glu Pro Ala Pro Val Ala Gly Pro Gly Arg Ser 
                405                 410                 415     


Gly Glu Pro Cys Gly Cys Gly Leu Arg Glu Ala Val Asp Gly Val Arg 
            420                 425                 430         


Phe Ile Ala Asp His Met Arg Ser Glu Asp Asp Asp Gln Ser Val Ser 
        435                 440                 445             


Glu Asp Trp Lys Tyr Val Ala Met Val Ile Asp Arg Leu Phe Leu Trp 
    450                 455                 460                 


Ile Phe Val Phe Val Cys Val Phe Gly Thr Ile Gly Met Phe Leu Gln 
465                 470                 475                 480 


Pro Leu Phe Gln Asn Tyr Thr Thr Thr Thr Phe Leu His Ser Asp His 
                485                 490                 495     


Ser Ala Pro Ser Ser Lys 
            500         

<210>  1228
<211>  570
<212>  DNA
<213>  Homo sapiens

<400>  1228
cctgttggga tgaatactaa aaggtggctg ttcgctgtct agtcaaggtg gaggcccctt     60

cccataggat tgtcacgcgg aataaagaca acgcatgctg aggacctggc gcagagcaga    120

cccttagtaa caggagctaa tactgggata caaacagccc caggtcccca aaccatccaa    180

agagccctcc ctgtttcctc ttccgtttca agaccattgg gggaaacggt cttgcccttc    240

ctctgccgta gccttcctca gtagaacaca ccacctgggg gctgctgtgt cttgtttgct    300

tttaaatttt caataacttg gtaccagctg ttctagtatt tctatctccc cgccaggaag    360

ctgccttcct cccactgcaa cgccacctgt caaaagcaga gagcctgtgc atgccttctt    420

ttcagacaaa aatagttctc agatcacctg tggccttgcc atctctgatg gagatagtct    480

caacctgttt cctcacttcc cctcccaaac ccttgctcca ggtttccatc cagtatctct    540

gccacctcca gatctggagc ttcctccagt                                     570


<210>  1229
<211>  52
<212>  PRT
<213>  Homo sapiens

<400>  1229


Met Pro Ser Phe Gln Thr Lys Ile Val Leu Arg Ser Pro Val Ala Leu 
1               5                   10                  15      


Pro Ser Leu Met Glu Ile Val Ser Thr Cys Phe Leu Thr Ser Pro Pro 
            20                  25                  30          


Lys Pro Leu Leu Gln Val Ser Ile Gln Tyr Leu Cys His Leu Gln Ile 
        35                  40                  45              


Trp Ser Phe Leu 
    50          

<210>  1230
<211>  1705
<212>  DNA
<213>  Homo sapiens

<400>  1230
atgccttgga atattgccaa gcttccagct gcctcttctc ctaaagcatt cctaggaata     60

ttttccccgc caatgctggg cgtacaccct agccaacggg acaaatccta gagggtataa    120

aatcatctct gctcagataa tcatgactta gcaagaataa gggcaaaaaa tcctgttggc    180

ttaacgtcac tgttccaccc ggtgtaatat ctctcatgac agtgacacca agggaagttg    240

actaagtcac atgtaaatta ggagtgtttt aaagaatgcc atagatgttg attcttaact    300

gctacagata acctgtaatt gagcagattt aaaattcagg catacttttc catttatcca    360

agtgctttca tttttccaga tggcttcaga agtaggctcg tgggcagggc gcagacctga    420

tctttatagg gttgacatag aaagcagtag ttgtgggtga aagggcaggt tgtcttcaaa    480

ctctgtgagg tagaatcctt tgtctatacc tccatgaaca ttgactcgtg tgttcagagc    540

ctttggcctc tctgtggagt ctggctctct ggctcctgtg cattctttga atagtcactc    600

gtaaaaactg tcagtgcttg aaactgtttc ctttactcat gttgaaggga ctttgttggc    660

ttttagagtg ttggtcatga ctccaagagc agagcaggga agagcccaag catagacttg    720

gtgccgtggt gatggctgca gtccagtttt gtgatgctgc ttttacgtgt ccctcgataa    780

cagtcagcta gacacactca ggaggactac tgaggctctg cgaccttcag gagctgagcc    840

tgcctctctc ctttagatga cagaccttca tctgggaacg tgctgagcca gcaccctcag    900

atgatttccc tccaaactgc tgactaggtc atcctctgtc tggtagagac attcacatct    960

ttgcttttat tctatgctct ctgtactttt gaccaaaaat tgaccaaagt aagaaaatgc   1020

aagttctaaa aatagactaa ggatgccttt gcagaacacc aaagcatccc aaggaactgg   1080

tagggaagtg gcgcctgtct cctggagtgg aagaggcctg ctccctggct ctgggtctgc   1140

tgggggcaca gtaaatcagt cttggcaccc acatccaggg cagagaggtc tgtggttctc   1200

agcatcagaa ggcagcgcag cccctctcct cttcaggcta cagggttgtc acctgctgag   1260

tcctcaggtt gtttggcctc tctggtccat cttgggcatt aggttctcca gcagagcttc   1320

tgcccactgt tatcttcact ttctttgtcc agtcttttgt ttttaataag cagtgaccct   1380

ccctactctt ctttttaatg atttttgtag ttgatttgtc tgaactgtgg ctactgtgca   1440

ttccttgaat aatcacttgt aaaaattgtc agtgcttgaa gctgtttcct ttactcacat   1500

tgaagggact tcgttggttt tttggagtct tggttgtgac tccaagagca gagtgaggaa   1560

gacccccaag catagactcg ggtactgtga tgatggctgc agtccagttt tatgattctg   1620

cttttatgtg tcccttgata acagtgactt aacaatatac attcctcata aataaaaaaa   1680

aaacaagaat ctgaattctt agaaa                                         1705


<210>  1231
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  1231


Met Pro Leu Gln Asn Thr Lys Ala Ser Gln Gly Thr Gly Arg Glu Val 
1               5                   10                  15      


Ala Pro Val Ser Trp Ser Gly Arg Gly Leu Leu Pro Gly Ser Gly Ser 
            20                  25                  30          


Ala Gly Gly Thr Val Asn Gln Ser Trp His Pro His Pro Gly Gln Arg 
        35                  40                  45              


Gly Leu Trp Phe Ser Ala Ser Glu Gly Ser Ala Ala Pro Leu Leu Phe 
    50                  55                  60                  


Arg Leu Gln Gly Cys His Leu Leu Ser Pro Gln Val Val Trp Pro Leu 
65                  70                  75                  80  


Trp Ser Ile Leu Gly Ile Arg Phe Ser Ser Arg Ala Ser Ala His Cys 
                85                  90                  95      


Tyr Leu His Phe Leu Cys Pro Val Phe Cys Phe 
            100                 105         

<210>  1232
<211>  2393
<212>  DNA
<213>  Homo sapiens

<400>  1232
attgctaggc aaggtctggc caggcccccc ttttttcccc caagtgaaga ggcagaaacc     60

taagaagtta tcttttcttt ctacccaaag catacatagt cactgagcac ctgcggtcca    120

tttcctctta aaagttttgt tttgatttgt ttccatttcc tttccctttg tgtttgctac    180

actgacctct tgcggtcttg attaggtttc agtcaactct ggatcatgtc agggactgat    240

aatttcattt gtggattacg cagacccctc tacttcccct ctttcccttc tgagattctt    300

tccttgtgat ctgaatgtct ccttttcccc ctcagagggc aaagaggtga acataaagga    360

tttggtgaaa catttgtaag ggtaggagtt gaaaactgca gttcccagtg ccacggaagt    420

gtgattggag cctgcagata atgcccagcc atcctcccat cctgcacttt agccagctgc    480

agggcgggca aggcaaggaa agctgcttcc ctggaagtgt atcactttct ccggcagctg    540

ggaagtctag aaccagccag actgggttaa gggagctgct caagcaatag cagaggtttc    600

acccggcagg atgacacaga ccacttccca gggagcacgg gcatgccttg gaatattgcc    660

aagcttccag ctgcctcttc tcctaaagca ttcctaggaa tattttcccc gccaatgctg    720

ggcgtacacc ctagccaacg ggacaaatcc tagagggtat aaaatcatct ctgctcagat    780

aatcatgact tagcaagaat aagggcaaaa aatcctgttg gcttaacgtc actgttccac    840

ccggtgtaat atctctcatg acagtgacac caagggaagt tgactaagtc acatgtaaat    900

taggagtgtt ttaaagaatg ccatagatgt tgtcttcaaa ctctgtgagg tagaatcctt    960

tgtctatacc tccatgaaca ttgactcgtg tgttcagagc ctttggcctc tctgtggagt   1020

ctggctctct ggctcctgtg cattctttga atagtcactc gtaaaaactg tcagtgcttg   1080

aaactgtttc ctttactcat gttgaaggga ctttgttggc ttttagagtg ttggtcatga   1140

ctccaagagc agagcaggga agagcccaag catagacttg gtgccgtggt gatggctgca   1200

gtccagtttt gtgatgctgc ttttacgtgt ccctcgataa cagtcagcta gacacactca   1260

ggaggactac tgaggctctg cgaccttcag gagctgagcc tgcctctctc ctttagatga   1320

cagaccttca tctgggaacg tgctgagcca gcaccctcag atgatttccc tccaaactgc   1380

tgactaggtc atcctctgtc tggtagagac attcacatct ttgcttttat tctatgctct   1440

ctgtactttt gaccaaaaat tgaccaaagt aagaaaatgc aagttctaaa aatagactaa   1500

ggatgccttt gcagaacacc aaagcatccc aaggaactgg tagggaagtg gcgcctgtct   1560

cctggagtgg aagaggcctg ctccctggct ctgggtctgc tgggggcaca gtaaatcagt   1620

cttggcaccc acatccaggg cagagaggtc tgtggttctc agcatcagaa ggcagcgcag   1680

cccctctcct cttcaggcta cagggttgtc acctgctgag tcctcaggtt gtttggcctc   1740

tctggtccat cttgggcatt aggttctcca gcagagctct ggccagctgc ctcttcttta   1800

actgggaaca caggctctca caagatcaga acccccactc acccccaaga tcttatctag   1860

caagcctgta gtattcagtt tctgttgtag gaagagagcg aggcatccct gaattccacg   1920

catctgctgg aaacgagccg tgtcagatcg cacatccctg cgcccccatg cccctctgag   1980

tcacacagga cagaggaggc agagcttctg cccactgtta tcttcacttt ctttgtccag   2040

tcttttgttt ttaataagca gtgaccctcc ctactcttct ttttaatgat ttttgtagtt   2100

gatttgtctg aactgtggct actgtgcatt ccttgaataa tcacttgtaa aaattgtcag   2160

tgcttgaagc tgtttccttt actcacattg aagggacttc gttggttttt tggagtcttg   2220

gttgtgactc caagagcaga gtgaggaaga cccccaagca tagactcggg tactgtgatg   2280

atggctgcag tccagtttta tgattctgct tttatgtgtc ccttgataac agtgacttaa   2340

caatatacat tcctcataaa taaaaaaaaa acaagaatct gaattcttag aaa          2393


<210>  1233
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  1233


Met Pro Leu Gln Asn Thr Lys Ala Ser Gln Gly Thr Gly Arg Glu Val 
1               5                   10                  15      


Ala Pro Val Ser Trp Ser Gly Arg Gly Leu Leu Pro Gly Ser Gly Ser 
            20                  25                  30          


Ala Gly Gly Thr Val Asn Gln Ser Trp His Pro His Pro Gly Gln Arg 
        35                  40                  45              


Gly Leu Trp Phe Ser Ala Ser Glu Gly Ser Ala Ala Pro Leu Leu Phe 
    50                  55                  60                  


Arg Leu Gln Gly Cys His Leu Leu Ser Pro Gln Val Val Trp Pro Leu 
65                  70                  75                  80  


Trp Ser Ile Leu Gly Ile Arg Phe Ser Ser Arg Ala Leu Ala Ser Cys 
                85                  90                  95      


Leu Phe Phe Asn Trp Glu His Arg Leu Ser Gln Asp Gln Asn Pro His 
            100                 105                 110         


Ser Pro Pro Arg Ser Tyr Leu Ala Ser Leu 
        115                 120         

<210>  1234
<211>  3644
<212>  DNA
<213>  Homo sapiens

<400>  1234
gtactcaggt taccttttca gccaagggca tctgacccgt gctatttgct gtcgtgtgac     60

aagagatggg agtgcatttg aggatggact acgacatccc tttattgtca accaccccaa    120

ggtgctataa cccccttcta ttttccctga cattttcctc cttttcaagc agtcatgtaa    180

acagaggaaa aatgtacact gtgggcaagg ggaacattgc ccacagtggt agcccacaag    240

ggaacattgc ccacagtggc ccaccaccaa cattggttgg tctcccaaga acttaaactt    300

tcttcctttt ggatgccaag ggcttttctt ctcttagtct ggaattaatc tgaatcgagg    360

tggagttagt atgtctagag ggtgctcagt cttagccaaa cagaacccta aatacagggg    420

aaagatcatg accccacact tcctctctcc tatgagtctt gagtccctgc ttcagaatct    480

tattcctgaa aggtttccat ctttctcccg ttgcttctgg gattcctagg ttggcagagt    540

cagcatatat gattccaaaa ggcaatccgg gaagactaag gagacaagcg tcaactggtg    600

tctggctgat ggctatgacc tggagatcct ggacggtacc agaggcactg tggatgggcc    660

acggaatgaa ttgtcccggg tctccaaaaa gaacattttt cttctattta agaagctctg    720

ctccttccgt taccgcaggg atctactgag actctcctat ggtgaggcca agaaagctgc    780

ccgtgactac gagacggcca agaactactt caaaaaaggc ctgaaggata tgggctatgg    840

gaactggatt agcaaacccc aggaggaaaa gaacttttat ctctgcccag tatagtatgc    900

tccagtgaca gatggattag ggtgtgtcat actagggtgt gagagaggta ggtcgtagca    960

ttcctcatca catggtcagg ggattttttt ttctcctttt tttttctttt taagccataa   1020

ttggtgatac tgaaaacttt gggttcccat ttatcctgct ttctttggga ttgctaggca   1080

aggtctggcc aggcccccct tttttccccc aagtgaagag gcagaaacct aagaagttat   1140

cttttctttc tacccaaagc atacatagtc actgagcacc tgcggtccat ttcctcttaa   1200

aagttttgtt ttgatttgtt tccatttcct ttccctttgt gtttgctaca ctgacctctt   1260

gcggtcttga ttaggtttca gtcaactctg gatcatgtca gggactgata atttcatttg   1320

tggattacgc agacccctct acttcccctc tttcccttct gagattcttt ccttgtgatc   1380

tgaatgtctc cttttccccc tcagagggca aagaggtgaa cataaaggat ttggtgaaac   1440

atttgtaagg gtaggagttg aaaactgcag ttcccagtgc cacggaagtg tgattggagc   1500

ctgcagataa tgcccagcca tcctcccatc ctgcacttta gccagctgca gggcgggcaa   1560

ggcaaggaaa gctgcttccc tggaagtgta tcactttctc cggcagctgg gaagtctaga   1620

accagccaga ctgggttaag ggagctgctc aagcaatagc agaggtttca cccggcagga   1680

tgacacagac cacttcccag ggagcacggg catgccttgg aatattgcca agcttccagc   1740

tgcctcttct cctaaagcat tcctaggaat attttccccg ccaatgctgg gcgtacaccc   1800

tagccaacgg gacaaatcct agagggtata aaatcatctc tgctcagata atcatgactt   1860

agcaagaata agggcaaaaa atcctgttgg cttaacgtca ctgttccacc cggtgtaata   1920

tctctcatga cagtgacacc aagggaagtt gactaagtca catgtaaatt aggagtgttt   1980

taaagaatgc catagatgtt gattcttaac tgctacagat aacctgtaat tgagcagatt   2040

taaaattcag gcatactttt ccatttatcc aagtgctttc atttttccag atggcttcag   2100

aagtaggctc gtgggcaggg cgcagacctg atctttatag ggttgacata gaaagcagta   2160

gttgtgggtg aaagggcagg ttgtcttcaa actctgtgag gtagaatcct ttgtctatac   2220

ctccatgaac attgactcgt gtgttcagag cctttggcct ctctgtggag tctggctctc   2280

tggctcctgt gcattctttg aatagtcact cgtaaaaact gtcagtgctt gaaactgttt   2340

cctttactca tgttgaaggg actttgttgg cttttagagt gttggtcatg actccaagag   2400

cagagcaggg aagagcccaa gcatagactt ggtgccgtgg tgatggctgc agtccagttt   2460

tgtgatgctg cttttacgtg tccctcgata acagtcagct agacacactc aggaggacta   2520

ctgaggctct gcgaccttca ggagctgagc ctgcctctct cctttagatg acagaccttc   2580

atctgggaac gtgctgagcc agcaccctca gatgatttcc ctccaaactg ctgactaggt   2640

catcctctgt ctggtagaga cattcacatc tttgctttta ttctatgctc tctgtacttt   2700

tgaccaaaaa ttgaccaaag taagaaaatg caagttctaa aaatagacta aggatgcctt   2760

tgcagaacac caaagcatcc caaggaactg gtagggaagt ggcgcctgtc tcctggagtg   2820

gaagaggcct gctccctggc tctgggtctg ctgggggcac agtaaatcag tcttggcacc   2880

cacatccagg gcagagaggt ctgtggttct cagcatcaga aggcagcgca gcccctctcc   2940

tcttcaggct acagggttgt cacctgctga gtcctcaggt tgtttggcct ctctggtcca   3000

tcttgggcat taggttctcc agcagagctc tggccagctg cctcttcttt aactgggaac   3060

acaggctctc acaagatcag aacccccact cacccccaag atcttatcta gcaagcctgt   3120

agtattcagt ttctgttgta ggaagagagc gaggcatccc tgaattccac gcatctgctg   3180

gaaacgagcc gtgtcagatc gcacatccct gcgcccccat gcccctctga gtcacacagg   3240

acagaggagg cagagcttct gcccactgtt atcttcactt tctttgtcca gtcttttgtt   3300

tttaataagc agtgaccctc cctactcttc tttttaatga tttttgtagt tgatttgtct   3360

gaactgtggc tactgtgcat tccttgaata atcacttgta aaaattgtca gtgcttgaag   3420

ctgtttcctt tactcacatt gaagggactt cgttggtttt ttggagtctt ggttgtgact   3480

ccaagagcag agtgaggaag acccccaagc atagactcgg gtactgtgat gatggctgca   3540

gtccagtttt atgattctgc ttttatgtgt cccttgataa cagtgactta acaatataca   3600

ttcctcataa ataaaaaaaa aacaagaatc tgaattctta gaaa                    3644


<210>  1235
<211>  66
<212>  PRT
<213>  Homo sapiens

<400>  1235


Met Ile Pro Lys Gly Asn Pro Gly Arg Leu Arg Arg Gln Ala Ser Thr 
1               5                   10                  15      


Gly Val Trp Leu Met Ala Met Thr Trp Arg Ser Trp Thr Val Pro Glu 
            20                  25                  30          


Ala Leu Trp Met Gly His Gly Met Asn Cys Pro Gly Ser Pro Lys Arg 
        35                  40                  45              


Thr Phe Phe Phe Tyr Leu Arg Ser Ser Ala Pro Ser Val Thr Ala Gly 
    50                  55                  60                  


Ile Tyr 
65      

<210>  1236
<211>  2617
<212>  DNA
<213>  Homo sapiens

<400>  1236
tactccctgg caaagaaggg caagctacag aaagaggcag gaacaccccc tttgtggaaa     60

atcgcggtct ccactcaggc ttggaaccag cacagcggag tggtaagacc agacggtcat    120

agccaaggag ccccaaactc agacccgagt ttggaaccgg aagacagaaa ctccacatct    180

gtctcagaag atcttcttga gccttttatt gcagtctcag ctcaggcttg gaaccagcac    240

agcggagtgg taagaccaga cagtcatagc caaggatccc caaactcaga cccaggtttg    300

gaacctgaag acagcaactc cacatctgcc ttggaagatc ctcttgagtt tttagacatg    360

gccgagatca aggagaaaat ctgcgactat ctcttcaatg tgtctgactc ctctgccctg    420

aatttggcta aaaatattgg ccttaccaag gcccgagata taaatgctgt gctaattgac    480

atggaaaggc agggggatgt ctatagacaa gggacaaccc ctcccatatg gcatttgaca    540

gacaagaagc gagagaggat gcaaatcaag agaaatacga acagtgttcc tgaaaccgct    600

ccagctgcaa tccctgagac caaaagaaac gcagagttcc tcacctgtaa tatacccaca    660

tcaaatgcct caaataacat ggtaaccaca gaaaaagtgg agaatgggca ggaacctgtc    720

ataaagttag aaaacaggca agaggccaga ccagaaccag caagactgaa accacctgtt    780

cattacaatg gcccctcaaa agcagggtat gttgactttg aaaatggcca gtgggccaca    840

gatgacatcc cagatgactt gaatagtatc cgcgcagcac caggtgagtt tcgagccatc    900

atggagatgc cctccttcta cagtcatggc ttgccacggt gttcacccta caagaaactg    960

acagagtgcc agctgaagaa ccccatcagc gggctgttag aatatgccca gttcgctagt   1020

caaacctgtg agttcaacat gatagagcag agtggaccac cccatgaacc tcgaagtagg   1080

ctcgtgggca gggcgcagac ctgatcttta tagggttgac atagaaagca gtagttgtgg   1140

gtgaaagggc aggttgtctt caaactctgt gaggtagaat cctttgtcta tacctccatg   1200

aacattgact cgtgtgttca gagcctttgg cctctctgtg gagtctggct ctctggctcc   1260

tgtgcattct ttgaatagtc actcgtaaaa actgtcagtg cttgaaactg tttcctttac   1320

tcatgttgaa gggactttgt tggcttttag agtgttggtc atgactccaa gagcagagca   1380

gggaagagcc caagcataga cttggtgccg tggtgatggc tgcagtccag ttttgtgatg   1440

ctgcttttac gtgtccctcg ataacagtca gctagacaca ctcaggagga ctactgaggc   1500

tctgcgacct tcaggagctg agcctgcctc tctcctttag atgacagacc ttcatctggg   1560

aacgtgctga gccagcaccc tcagatgatt tccctccaaa ctgctgacta ggtcatcctc   1620

tgtctggtag agacattcac atctttgctt ttattctatg ctctctgtac ttttgaccaa   1680

aaattgacca aagtaagaaa atgcaagttc taaaaataga ctaaggatgc ctttgcagaa   1740

caccaaagca tcccaaggaa ctggtaggga agtggcgcct gtctcctgga gtggaagagg   1800

cctgctccct ggctctgggt ctgctggggg cacagtaaat cagtcttggc acccacatcc   1860

agggcagaga ggtctgtggt tctcagcatc agaaggcagc gcagcccctc tcctcttcag   1920

gctacagggt tgtcacctgc tgagtcctca ggttgtttgg cctctctggt ccatcttggg   1980

cattaggttc tccagcagag ctctggccag ctgcctcttc tttaactggg aacacaggct   2040

ctcacaagat cagaaccccc actcaccccc aagatcttat ctagcaagcc tgtagtattc   2100

agtttctgtt gtaggaagag agcgaggcat ccctgaattc cacgcatctg ctggaaacga   2160

gccgtgtcag atcgcacatc cctgcgcccc catgcccctc tgagtcacac aggacagagg   2220

aggcagagct tctgcccact gttatcttca ctttctttgt ccagtctttt gtttttaata   2280

agcagtgacc ctccctactc ttctttttaa tgatttttgt agttgatttg tctgaactgt   2340

ggctactgtg cattccttga ataatcactt gtaaaaattg tcagtgcttg aagctgtttc   2400

ctttactcac attgaaggga cttcgttggt tttttggagt cttggttgtg actccaagag   2460

cagagtgagg aagaccccca agcatagact cgggtactgt gatgatggct gcagtccagt   2520

tttatgattc tgcttttatg tgtcccttga taacagtgac ttaacaatat acattcctca   2580

taaataaaaa aaaaacaaga atctgaattc ttagaaa                            2617


<210>  1237
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  1237


Met Ala Glu Ile Lys Glu Lys Ile Cys Asp Tyr Leu Phe Asn Val Ser 
1               5                   10                  15      


Asp Ser Ser Ala Leu Asn Leu Ala Lys Asn Ile Gly Leu Thr Lys Ala 
            20                  25                  30          


Arg Asp Ile Asn Ala Val Leu Ile Asp Met Glu Arg Gln Gly Asp Val 
        35                  40                  45              


Tyr Arg Gln Gly Thr Thr Pro Pro Ile Trp His Leu Thr Asp Lys Lys 
    50                  55                  60                  


Arg Glu Arg Met Gln Ile Lys Arg Asn Thr Asn Ser Val Pro Glu Thr 
65                  70                  75                  80  


Ala Pro Ala Ala Ile Pro Glu Thr Lys Arg Asn Ala Glu Phe Leu Thr 
                85                  90                  95      


Cys Asn Ile Pro Thr Ser Asn Ala Ser Asn Asn Met Val Thr Thr Glu 
            100                 105                 110         


Lys Val Glu Asn Gly Gln Glu Pro Val Ile Lys Leu Glu Asn Arg Gln 
        115                 120                 125             


Glu Ala Arg Pro Glu Pro Ala Arg Leu Lys Pro Pro Val His Tyr Asn 
    130                 135                 140                 


Gly Pro Ser Lys Ala Gly Tyr Val Asp Phe Glu Asn Gly Gln Trp Ala 
145                 150                 155                 160 


Thr Asp Asp Ile Pro Asp Asp Leu Asn Ser Ile Arg Ala Ala Pro Gly 
                165                 170                 175     


Glu Phe Arg Ala Ile Met Glu Met Pro Ser Phe Tyr Ser His Gly Leu 
            180                 185                 190         


Pro Arg Cys Ser Pro Tyr Lys Lys Leu Thr Glu Cys Gln Leu Lys Asn 
        195                 200                 205             


Pro Ile Ser Gly Leu Leu Glu Tyr Ala Gln Phe Ala Ser Gln Thr Cys 
    210                 215                 220                 


Glu Phe Asn Met Ile Glu Gln Ser Gly Pro Pro His Glu Pro Arg Ser 
225                 230                 235                 240 


Arg Leu Val Gly Arg Ala Gln Thr 
                245             

<210>  1238
<211>  6710
<212>  DNA
<213>  Homo sapiens

<400>  1238
cagcactttg ggaggccgag gagggcggat caggagatcg acaccatcct ggccagcatg     60

gtgaaacccc atctctacta aaaatacaaa aattagctgg gtgtggtggc gtgcgcctgt    120

aatcccagct actccggagg ctgaggcagg agaatcactt gaacccggga ggcggagatt    180

gcagtgagct gagatcacac tgcactccag cctgattgca gtgagccgag atcatgccac    240

tgcactccag cttggcaaca gagcgagact ccgtctcaca agaaaaaaaa taaccgggta    300

ttccctcagc ggatactaca cccatccatt tcaaggctat gagcacagac agctcaggta    360

ccagcagcct gggccaggat cttcccccag tagtttcctg cttaagcaaa tagaatttct    420

caaggggcag ctcccagaag caccggtgat tggaaagcag acaccgtcac tgccaccttc    480

cctcccagga ctccggccaa ggtttccagt actacttgcc tccagtacca gaggcaggca    540

agtggacatc aggggtgtcc ccaggggcgt gcatctcaga agtcaggggc tccagagagg    600

gttccagcat ccttcaccac gtggcaggag tctgccacag agaggtgttg attgcctttc    660

ctcacatttc caggaactga gtatctacca agatcaggaa caaaggatct taaagttcct    720

ggaagagctt ggggaaggga aggccaccac agcacatgat ctgtctggga aacttgggac    780

tccgaagaaa gaaatcaatc gagttttata ctccctggca aagaagggca agctacagaa    840

agaggcagga acaccccctt tgtggaaaat cgcggtctcc actcaggctt ggaaccagca    900

cagcggagtg gtaagaccag acggtcatag ccaaggagcc ccaaactcag acccgagttt    960

ggaaccggaa gacagaaact ccacatctgt ctcagaagat cttcttgagc cttttattgc   1020

agtctcagct caggcttgga accagcacag cggagtggta agaccagaca gtcatagcca   1080

aggatcccca aactcagacc caggtttgga acctgaagac agcaactcca catctgcctt   1140

ggaagatcct cttgagtttt tagacatggc cgagatcaag gagaaaatct gcgactatct   1200

cttcaatgtg tctgactcct ctgccctgaa tttggctaaa aatattggcc ttaccaaggc   1260

ccgagatata aatgctgtgc taattgacat ggaaaggcag ggggatgtct atagacaagg   1320

gacaacccct cccatatggc atttgacaga caagaagcga gagaggatgc aaatcaagag   1380

aaatacgaac agtgttcctg aaaccgctcc agctgcaatc cctgagacca aaagaaacgc   1440

agagttcctc acctgtaata tacccacatc aaatgcctca aataacatgg taaccacaga   1500

aaaagtggag aatgggcagg aacctgtcat aaagttagaa aacaggcaag aggccagacc   1560

agaaccagca agactgaaac cacctgttca ttacaatggc ccctcaaaag cagggtatgt   1620

tgactttgaa aatggccagt gggccacaga tgacatccca gatgacttga atagtatccg   1680

cgcagcacca ggtgagtttc gagccatcat ggagatgccc tccttctaca gtcatggctt   1740

gccacggtgt tcaccctaca agaaactgac agagtgccag ctgaagaacc ccatcagcgg   1800

gctgttagaa tatgcccagt tcgctagtca aacctgtgag ttcaacatga tagagcagag   1860

tggaccaccc catgaacctc gatttaaatt ccaggttgtc atcaatggcc gagagtttcc   1920

cccagctgaa gctggaagca agaaagtggc caagcaggat gcagctatga aagccatgac   1980

aattctgcta gaggaagcca aagccaagga cagtggaaaa tcagaagaat catcccacta   2040

ttccacagag aaagaatcag agaagactgc agagtcccag acccccaccc cttcagccac   2100

atccttcttt tctgggaaga gccccgtcac cacactgctt gagtgtatgc acaaattggg   2160

gaactcctgc gaattccgtc tcctgtccaa agaaggccct gcccatgaac ccaagttcca   2220

atactgtgtt gcagtgggag cccaaacttt ccccagtgtg agtgctccca gcaagaaagt   2280

ggcaaagcag atggccgcag aggaagccat gaaggccctg catggggagg cgaccaactc   2340

catggcttct gataaccagc ctgaaggtat gatctcagag tcacttgata acttggaatc   2400

catgatgccc aacaaggtca ggaagattgg cgagctcgtg agatacctga acaccaaccc   2460

tgtgggtggc cttttggagt acgcccgctc ccatggcttt gctgctgaat tcaagttggt   2520

cgaccagtcc ggacctcctc acgagcccaa gttcgtttac caagcaaaag ttgggggtcg   2580

ctggttccca gccgtctgcg cacacagcaa gaagcaaggc aagcaggaag cagcagatgc   2640

ggctctccgt gtcttgattg gggagaacga gaaggcagaa cgcatgggtt tcacagaggt   2700

aaccccagtg acaggggcca gtctcagaag aactatgctc ctcctctcaa ggtccccaga   2760

agcacagcca aagacactcc ctctcactgg cagcaccttc catgaccaga tagccatgct   2820

gagccaccgg tgcttcaaca ctctgactaa cagcttccag ccctccttgc tcggccgcaa   2880

gattctggcc gccatcatta tgaaaaaaga ctctgaggac atgggtgtcg tcgtcagctt   2940

gggaacaggg aatcgctgtg tgaaaggaga ttctctcagc ctaaaaggag aaactgtcaa   3000

tgactgccat gcagaaataa tctcccggag aggcttcatc aggtttctct acagtgagtt   3060

aatgaaatac aactcccaga ctgcgaagga tagtatattt gaacctgcta agggaggaga   3120

aaagctccaa ataaaaaaga ctgtgtcatt ccatctgtat atcagcactg ctccgtgtgg   3180

agatggcgcc ctctttgaca agtcctgcag cgaccgtgct atggaaagca cagaatcccg   3240

ccactaccct gtcttcgaga atcccaaaca aggaaagctc cgcaccaagg tggagaacgg   3300

agaaggcaca atccctgtgg aatccagtga cattgtgcct acgtgggatg gcattcggct   3360

cggggagaga ctccgtacca tgtcctgtag tgacaaaatc ctacgctgga acgtgctggg   3420

cctgcaaggg gcactgttga cccacttcct gcagcccatt tatctcaaat ctgtcacatt   3480

gggttacctt ttcagccaag ggcatctgac ccgtgctatt tgctgtcgtg tgacaagaga   3540

tgggagtgca tttgaggatg gactacgaca tccctttatt gtcaaccacc ccaaggttgg   3600

cagagtcagc atatatgatt ccaaaaggca atccgggaag actaaggaga caagcgtcaa   3660

ctggtgtctg gctgatggct atgacctgga gatcctggac ggtaccagag gcactgtgga   3720

tgggccacgg aatgaattgt cccgggtctc caaaaagaac atttttcttc tatttaagaa   3780

gctctgctcc ttccgttacc gcagggatct actgagactc tcctatggtg aggccaagaa   3840

agctgcccgt gactacgaga cggccaagaa ctacttcaaa aaaggcctga aggatatggg   3900

ctatgggaac tggattagca aaccccagga ggaaaagaac ttttatctct gcccagtata   3960

gtatgctcca gtgacagatg gattagggtg tgtcatacta gggtgtgaga gaggtaggtc   4020

gtagcattcc tcatcacatg gtcaggggat ttttttttct cctttttttt tctttttaag   4080

ccataattgg tgatactgaa aactttgggt tcccatttat cctgctttct ttgggattgc   4140

taggcaaggt ctggccaggc cccccttttt tcccccaagt gaagaggcag aaacctaaga   4200

agttatcttt tctttctacc caaagcatac atagtcactg agcacctgcg gtccatttcc   4260

tcttaaaagt tttgttttga tttgtttcca tttcctttcc ctttgtgttt gctacactga   4320

cctcttgcgg tcttgattag gtttcagtca actctggatc atgtcaggga ctgataattt   4380

catttgtgga ttacgcagac ccctctactt cccctctttc ccttctgaga ttctttcctt   4440

gtgatctgaa tgtctccttt tccccctcag agggcaaaga ggtgaacata aaggatttgg   4500

tgaaacattt gtaagggtag gagttgaaaa ctgcagttcc cagtgccacg gaagtgtgat   4560

tggagcctgc agataatgcc cagccatcct cccatcctgc actttagcca gctgcagggc   4620

gggcaaggca aggaaagctg cttccctgga agtgtatcac tttctccggc agctgggaag   4680

tctagaacca gccagactgg gttaagggag ctgctcaagc aatagcagag gtttcacccg   4740

gcaggatgac acagaccact tcccagggag cacgggcatg ccttggaata ttgccaagct   4800

tccagctgcc tcttctccta aagcattcct aggaatattt tccccgccaa tgctgggcgt   4860

acaccctagc caacgggaca aatcctagag ggtataaaat catctctgct cagataatca   4920

tgacttagca agaataaggg caaaaaatcc tgttggctta acgtcactgt tccacccggt   4980

gtaatatctc tcatgacagt gacaccaagg gaagttgact aagtcacatg taaattagga   5040

gtgttttaaa gaatgccata gatgttgatt cttaactgct acagataacc tgtaattgag   5100

cagatttaaa attcaggcat acttttccat ttatccaagt gctttcattt ttccagatgg   5160

cttcagaagt aggctcgtgg gcagggcgca gacctgatct ttatagggtt gacatagaaa   5220

gcagtagttg tgggtgaaag ggcaggttgt cttcaaactc tgtgaggtag aatcctttgt   5280

ctatacctcc atgaacattg actcgtgtgt tcagagcctt tggcctctct gtggagtctg   5340

gctctctggc tcctgtgcat tctttgaata gtcactcgta aaaactgtca gtgcttgaaa   5400

ctgtttcctt tactcatgtt gaagggactt tgttggcttt tagagtgttg gtcatgactc   5460

caagagcaga gcagggaaga gcccaagcat agacttggtg ccgtggtgat ggctgcagtc   5520

cagttttgtg atgctgcttt tacgtgtccc tcgataacag tcagctagac acactcagga   5580

ggactactga ggctctgcga ccttcaggag ctgagcctgc ctctctcctt tagatgacag   5640

accttcatct gggaacgtgc tgagccagca ccctcagatg atttccctcc aaactgctga   5700

ctaggtcatc ctctgtctgg tagagacatt cacatctttg cttttattct atgctctctg   5760

tacttttgac caaaaattga ccaaagtaag aaaatgcaag ttctaaaaat agactaagga   5820

tgcctttgca gaacaccaaa gcatcccaag gaactggtag ggaagtggcg cctgtctcct   5880

ggagtggaag aggcctgctc cctggctctg ggtctgctgg gggcacagta aatcagtctt   5940

ggcacccaca tccagggcag agaggtctgt ggttctcagc atcagaaggc agcgcagccc   6000

ctctcctctt caggctacag ggttgtcacc tgctgagtcc tcaggttgtt tggcctctct   6060

ggtccatctt gggcattagg ttctccagca gagctctggc cagctgcctc ttctttaact   6120

gggaacacag gctctcacaa gatcagaacc cccactcacc cccaagatct tatctagcaa   6180

gcctgtagta ttcagtttct gttgtaggaa gagagcgagg catccctgaa ttccacgcat   6240

ctgctggaaa cgagccgtgt cagatcgcac atccctgcgc ccccatgccc ctctgagtca   6300

cacaggacag aggaggcaga gcttctgccc actgttatct tcactttctt tgtccagtct   6360

tttgttttta ataagcagtg accctcccta ctcttctttt taatgatttt tgtagttgat   6420

ttgtctgaac tgtggctact gtgcattcct tgaataatca cttgtaaaaa ttgtcagtgc   6480

ttgaagctgt ttcctttact cacattgaag ggacttcgtt ggttttttgg agtcttggtt   6540

gtgactccaa gagcagagtg aggaagaccc ccaagcatag actcgggtac tgtgatgatg   6600

gctgcagtcc agttttatga ttctgctttt atgtgtccct tgataacagt gacttaacaa   6660

tatacattcc tcataaataa aaaaaaaaca agaatctgaa ttcttagaaa              6710


<210>  1239
<211>  931
<212>  PRT
<213>  Homo sapiens

<400>  1239


Met Ala Glu Ile Lys Glu Lys Ile Cys Asp Tyr Leu Phe Asn Val Ser 
1               5                   10                  15      


Asp Ser Ser Ala Leu Asn Leu Ala Lys Asn Ile Gly Leu Thr Lys Ala 
            20                  25                  30          


Arg Asp Ile Asn Ala Val Leu Ile Asp Met Glu Arg Gln Gly Asp Val 
        35                  40                  45              


Tyr Arg Gln Gly Thr Thr Pro Pro Ile Trp His Leu Thr Asp Lys Lys 
    50                  55                  60                  


Arg Glu Arg Met Gln Ile Lys Arg Asn Thr Asn Ser Val Pro Glu Thr 
65                  70                  75                  80  


Ala Pro Ala Ala Ile Pro Glu Thr Lys Arg Asn Ala Glu Phe Leu Thr 
                85                  90                  95      


Cys Asn Ile Pro Thr Ser Asn Ala Ser Asn Asn Met Val Thr Thr Glu 
            100                 105                 110         


Lys Val Glu Asn Gly Gln Glu Pro Val Ile Lys Leu Glu Asn Arg Gln 
        115                 120                 125             


Glu Ala Arg Pro Glu Pro Ala Arg Leu Lys Pro Pro Val His Tyr Asn 
    130                 135                 140                 


Gly Pro Ser Lys Ala Gly Tyr Val Asp Phe Glu Asn Gly Gln Trp Ala 
145                 150                 155                 160 


Thr Asp Asp Ile Pro Asp Asp Leu Asn Ser Ile Arg Ala Ala Pro Gly 
                165                 170                 175     


Glu Phe Arg Ala Ile Met Glu Met Pro Ser Phe Tyr Ser His Gly Leu 
            180                 185                 190         


Pro Arg Cys Ser Pro Tyr Lys Lys Leu Thr Glu Cys Gln Leu Lys Asn 
        195                 200                 205             


Pro Ile Ser Gly Leu Leu Glu Tyr Ala Gln Phe Ala Ser Gln Thr Cys 
    210                 215                 220                 


Glu Phe Asn Met Ile Glu Gln Ser Gly Pro Pro His Glu Pro Arg Phe 
225                 230                 235                 240 


Lys Phe Gln Val Val Ile Asn Gly Arg Glu Phe Pro Pro Ala Glu Ala 
                245                 250                 255     


Gly Ser Lys Lys Val Ala Lys Gln Asp Ala Ala Met Lys Ala Met Thr 
            260                 265                 270         


Ile Leu Leu Glu Glu Ala Lys Ala Lys Asp Ser Gly Lys Ser Glu Glu 
        275                 280                 285             


Ser Ser His Tyr Ser Thr Glu Lys Glu Ser Glu Lys Thr Ala Glu Ser 
    290                 295                 300                 


Gln Thr Pro Thr Pro Ser Ala Thr Ser Phe Phe Ser Gly Lys Ser Pro 
305                 310                 315                 320 


Val Thr Thr Leu Leu Glu Cys Met His Lys Leu Gly Asn Ser Cys Glu 
                325                 330                 335     


Phe Arg Leu Leu Ser Lys Glu Gly Pro Ala His Glu Pro Lys Phe Gln 
            340                 345                 350         


Tyr Cys Val Ala Val Gly Ala Gln Thr Phe Pro Ser Val Ser Ala Pro 
        355                 360                 365             


Ser Lys Lys Val Ala Lys Gln Met Ala Ala Glu Glu Ala Met Lys Ala 
    370                 375                 380                 


Leu His Gly Glu Ala Thr Asn Ser Met Ala Ser Asp Asn Gln Pro Glu 
385                 390                 395                 400 


Gly Met Ile Ser Glu Ser Leu Asp Asn Leu Glu Ser Met Met Pro Asn 
                405                 410                 415     


Lys Val Arg Lys Ile Gly Glu Leu Val Arg Tyr Leu Asn Thr Asn Pro 
            420                 425                 430         


Val Gly Gly Leu Leu Glu Tyr Ala Arg Ser His Gly Phe Ala Ala Glu 
        435                 440                 445             


Phe Lys Leu Val Asp Gln Ser Gly Pro Pro His Glu Pro Lys Phe Val 
    450                 455                 460                 


Tyr Gln Ala Lys Val Gly Gly Arg Trp Phe Pro Ala Val Cys Ala His 
465                 470                 475                 480 


Ser Lys Lys Gln Gly Lys Gln Glu Ala Ala Asp Ala Ala Leu Arg Val 
                485                 490                 495     


Leu Ile Gly Glu Asn Glu Lys Ala Glu Arg Met Gly Phe Thr Glu Val 
            500                 505                 510         


Thr Pro Val Thr Gly Ala Ser Leu Arg Arg Thr Met Leu Leu Leu Ser 
        515                 520                 525             


Arg Ser Pro Glu Ala Gln Pro Lys Thr Leu Pro Leu Thr Gly Ser Thr 
    530                 535                 540                 


Phe His Asp Gln Ile Ala Met Leu Ser His Arg Cys Phe Asn Thr Leu 
545                 550                 555                 560 


Thr Asn Ser Phe Gln Pro Ser Leu Leu Gly Arg Lys Ile Leu Ala Ala 
                565                 570                 575     


Ile Ile Met Lys Lys Asp Ser Glu Asp Met Gly Val Val Val Ser Leu 
            580                 585                 590         


Gly Thr Gly Asn Arg Cys Val Lys Gly Asp Ser Leu Ser Leu Lys Gly 
        595                 600                 605             


Glu Thr Val Asn Asp Cys His Ala Glu Ile Ile Ser Arg Arg Gly Phe 
    610                 615                 620                 


Ile Arg Phe Leu Tyr Ser Glu Leu Met Lys Tyr Asn Ser Gln Thr Ala 
625                 630                 635                 640 


Lys Asp Ser Ile Phe Glu Pro Ala Lys Gly Gly Glu Lys Leu Gln Ile 
                645                 650                 655     


Lys Lys Thr Val Ser Phe His Leu Tyr Ile Ser Thr Ala Pro Cys Gly 
            660                 665                 670         


Asp Gly Ala Leu Phe Asp Lys Ser Cys Ser Asp Arg Ala Met Glu Ser 
        675                 680                 685             


Thr Glu Ser Arg His Tyr Pro Val Phe Glu Asn Pro Lys Gln Gly Lys 
    690                 695                 700                 


Leu Arg Thr Lys Val Glu Asn Gly Glu Gly Thr Ile Pro Val Glu Ser 
705                 710                 715                 720 


Ser Asp Ile Val Pro Thr Trp Asp Gly Ile Arg Leu Gly Glu Arg Leu 
                725                 730                 735     


Arg Thr Met Ser Cys Ser Asp Lys Ile Leu Arg Trp Asn Val Leu Gly 
            740                 745                 750         


Leu Gln Gly Ala Leu Leu Thr His Phe Leu Gln Pro Ile Tyr Leu Lys 
        755                 760                 765             


Ser Val Thr Leu Gly Tyr Leu Phe Ser Gln Gly His Leu Thr Arg Ala 
    770                 775                 780                 


Ile Cys Cys Arg Val Thr Arg Asp Gly Ser Ala Phe Glu Asp Gly Leu 
785                 790                 795                 800 


Arg His Pro Phe Ile Val Asn His Pro Lys Val Gly Arg Val Ser Ile 
                805                 810                 815     


Tyr Asp Ser Lys Arg Gln Ser Gly Lys Thr Lys Glu Thr Ser Val Asn 
            820                 825                 830         


Trp Cys Leu Ala Asp Gly Tyr Asp Leu Glu Ile Leu Asp Gly Thr Arg 
        835                 840                 845             


Gly Thr Val Asp Gly Pro Arg Asn Glu Leu Ser Arg Val Ser Lys Lys 
    850                 855                 860                 


Asn Ile Phe Leu Leu Phe Lys Lys Leu Cys Ser Phe Arg Tyr Arg Arg 
865                 870                 875                 880 


Asp Leu Leu Arg Leu Ser Tyr Gly Glu Ala Lys Lys Ala Ala Arg Asp 
                885                 890                 895     


Tyr Glu Thr Ala Lys Asn Tyr Phe Lys Lys Gly Leu Lys Asp Met Gly 
            900                 905                 910         


Tyr Gly Asn Trp Ile Ser Lys Pro Gln Glu Glu Lys Asn Phe Tyr Leu 
        915                 920                 925             


Cys Pro Val 
    930     

<210>  1240
<211>  6930
<212>  DNA
<213>  Homo sapiens

<400>  1240
ggacgggcgc gggggctgac gcctgtaatc ccaacacttt gggaggccga ggtgggcgga     60

tctcttgaag ccgggagttc gagaccaccc tggctaacgt ggtgaaaccc tgttcttact    120

aaaaatacaa aaaaaaaaaa aaaaaaaaag ccaggagtga tggcgctcgc ctgtaatccc    180

agctactccg taggctgagg caggagaatc gcttgaaccc ggggggcaga ggttgcagtg    240

agccgagatt gcgccattgc actccagcct gggcaaaaag agcgagactc cgcctcaaaa    300

aaaaaaaaaa aagtaccttc cgtagttctc atgcagcgga ggggttcgac ttgtaaccgg    360

cctgaaacca agcgtggcgc aagatttgct caagcccctc ctcttggcca aactttccgg    420

aggggaaggc tttccgagga aacgaaagcg aaattgaacc ggagccatct tgggcccggc    480

gcgcagaccc gcggagtttc ccgtgccgac gccccggggc cacttccagt gcggagtagc    540

ggaggcgtgg gggcctcgag gggctggcgc ggcccagcgg tcgggccagg gtcgtgccgc    600

cggcgggtcg ggccgggcaa tgcctcgcgg gcgcaatgaa tccgcggcag gggtattccc    660

tcagcggata ctacacccat ccatttcaag gctatgagca cagacagctc aggtaccagc    720

agcctgggcc aggatcttcc cccagtagtt tcctgcttaa gcaaatagaa tttctcaagg    780

ggcagctccc agaagcaccg gtgattggaa agcagacacc gtcactgcca ccttccctcc    840

caggactccg gccaaggttt ccagtactac ttgcctccag taccagaggc aggcaagtgg    900

acatcagggg tgtccccagg ggcgtgcatc tcagaagtca ggggctccag agagggttcc    960

agcatccttc accacgtggc aggagtctgc cacagagagg tgttgattgc ctttcctcac   1020

atttccagga actgagtatc taccaagatc aggaacaaag gatcttaaag ttcctggaag   1080

agcttgggga agggaaggcc accacagcac atgatctgtc tgggaaactt gggactccga   1140

agaaagaaat caatcgagtt ttatactccc tggcaaagaa gggcaagcta cagaaagagg   1200

caggaacacc ccctttgtgg aaaatcgcgg tctccactca ggcttggaac cagcacagcg   1260

gagtggtaag accagacggt catagccaag gagccccaaa ctcagacccg agtttggaac   1320

cggaagacag aaactccaca tctgtctcag aagatcttct tgagcctttt attgcagtct   1380

cagctcaggc ttggaaccag cacagcggag tggtaagacc agacagtcat agccaaggat   1440

ccccaaactc agacccaggt ttggaacctg aagacagcaa ctccacatct gccttggaag   1500

atcctcttga gtttttagac atggccgaga tcaaggagaa aatctgcgac tatctcttca   1560

atgtgtctga ctcctctgcc ctgaatttgg ctaaaaatat tggccttacc aaggcccgag   1620

atataaatgc tgtgctaatt gacatggaaa ggcaggggga tgtctataga caagggacaa   1680

cccctcccat atggcatttg acagacaaga agcgagagag gatgcaaatc aagagaaata   1740

cgaacagtgt tcctgaaacc gctccagctg caatccctga gaccaaaaga aacgcagagt   1800

tcctcacctg taatataccc acatcaaatg cctcaaataa catggtaacc acagaaaaag   1860

tggagaatgg gcaggaacct gtcataaagt tagaaaacag gcaagaggcc agaccagaac   1920

cagcaagact gaaaccacct gttcattaca atggcccctc aaaagcaggg tatgttgact   1980

ttgaaaatgg ccagtgggcc acagatgaca tcccagatga cttgaatagt atccgcgcag   2040

caccaggtga gtttcgagcc atcatggaga tgccctcctt ctacagtcat ggcttgccac   2100

ggtgttcacc ctacaagaaa ctgacagagt gccagctgaa gaaccccatc agcgggctgt   2160

tagaatatgc ccagttcgct agtcaaacct gtgagttcaa catgatagag cagagtggac   2220

caccccatga acctcgattt aaattccagg ttgtcatcaa tggccgagag tttcccccag   2280

ctgaagctgg aagcaagaaa gtggccaagc aggatgcagc tatgaaagcc atgacaattc   2340

tgctagagga agccaaagcc aaggacagtg gaaaatcaga agaatcatcc cactattcca   2400

cagagaaaga atcagagaag actgcagagt cccagacccc caccccttca gccacatcct   2460

tcttttctgg gaagagcccc gtcaccacac tgcttgagtg tatgcacaaa ttggggaact   2520

cctgcgaatt ccgtctcctg tccaaagaag gccctgccca tgaacccaag ttccaatact   2580

gtgttgcagt gggagcccaa actttcccca gtgtgagtgc tcccagcaag aaagtggcaa   2640

agcagatggc cgcagaggaa gccatgaagg ccctgcatgg ggaggcgacc aactccatgg   2700

cttctgataa ccaggtcagg aagattggcg agctcgtgag atacctgaac accaaccctg   2760

tgggtggcct tttggagtac gcccgctccc atggctttgc tgctgaattc aagttggtcg   2820

accagtccgg acctcctcac gagcccaagt tcgtttacca agcaaaagtt gggggtcgct   2880

ggttcccagc cgtctgcgca cacagcaaga agcaaggcaa gcaggaagca gcagatgcgg   2940

ctctccgtgt cttgattggg gagaacgaga aggcagaacg catgggtttc acagagctcc   3000

ctctcactgg cagcaccttc catgaccaga tagccatgct gagccaccgg tgcttcaaca   3060

ctctgactaa cagcttccag ccctccttgc tcggccgcaa gattctggcc gccatcatta   3120

tgaaaaaaga ctctgaggac atgggtgtcg tcgtcagctt gggaacaggg aatcgctgtg   3180

tgaaaggaga ttctctcagc ctaaaaggag aaactgtcaa tgactgccat gcagaaataa   3240

tctcccggag aggcttcatc aggtttctct acagtgagtt aatgaaatac aactcccaga   3300

ctgcgaagga tagtatattt gaacctgcta agggaggaga aaagctccaa ataaaaaaga   3360

ctgtgtcatt ccatctgtat atcagcactg ctccgtgtgg agatggcgcc ctctttgaca   3420

agtcctgcag cgaccgtgct atggaaagca cagaatcccg ccactaccct gtcttcgaga   3480

atcccaaaca aggaaagctc cgcaccaagg tggagaacgg agaaggcaca atccctgtgg   3540

aatccagtga cattgtgcct acgtgggatg gcattcggct cggggagaga ctccgtacca   3600

tgtcctgtag tgacaaaatc ctacgctgga acgtgctggg cctgcaaggg gcactgttga   3660

cccacttcct gcagcccatt tatctcaaat ctgtcacatt gggttacctt ttcagccaag   3720

ggcatctgac ccgtgctatt tgctgtcgtg tgacaagaga tgggagtgca tttgaggatg   3780

gactacgaca tccctttatt gtcaaccacc ccaaggttgg cagagtcagc atatatgatt   3840

ccaaaaggca atccgggaag actaaggaga caagcgtcaa ctggtgtctg gctgatggct   3900

atgacctgga gatcctggac ggtaccagag gcactgtgga tgggccacgg aatgaattgt   3960

cccgggtctc caaaaagaac atttttcttc tatttaagaa gctctgctcc ttccgttacc   4020

gcagggatct actgagactc tcctatggtg aggccaagaa agctgcccgt gactacgaga   4080

cggccaagaa ctacttcaaa aaaggcctga aggatatggg ctatgggaac tggattagca   4140

aaccccagga ggaaaagaac ttttatctct gcccagtata gtatgctcca gtgacagatg   4200

gattagggtg tgtcatacta gggtgtgaga gaggtaggtc gtagcattcc tcatcacatg   4260

gtcaggggat ttttttttct cctttttttt tctttttaag ccataattgg tgatactgaa   4320

aactttgggt tcccatttat cctgctttct ttgggattgc taggcaaggt ctggccaggc   4380

cccccttttt tcccccaagt gaagaggcag aaacctaaga agttatcttt tctttctacc   4440

caaagcatac atagtcactg agcacctgcg gtccatttcc tcttaaaagt tttgttttga   4500

tttgtttcca tttcctttcc ctttgtgttt gctacactga cctcttgcgg tcttgattag   4560

gtttcagtca actctggatc atgtcaggga ctgataattt catttgtgga ttacgcagac   4620

ccctctactt cccctctttc ccttctgaga ttctttcctt gtgatctgaa tgtctccttt   4680

tccccctcag agggcaaaga ggtgaacata aaggatttgg tgaaacattt gtaagggtag   4740

gagttgaaaa ctgcagttcc cagtgccacg gaagtgtgat tggagcctgc agataatgcc   4800

cagccatcct cccatcctgc actttagcca gctgcagggc gggcaaggca aggaaagctg   4860

cttccctgga agtgtatcac tttctccggc agctgggaag tctagaacca gccagactgg   4920

gttaagggag ctgctcaagc aatagcagag gtttcacccg gcaggatgac acagaccact   4980

tcccagggag cacgggcatg ccttggaata ttgccaagct tccagctgcc tcttctccta   5040

aagcattcct aggaatattt tccccgccaa tgctgggcgt acaccctagc caacgggaca   5100

aatcctagag ggtataaaat catctctgct cagataatca tgacttagca agaataaggg   5160

caaaaaatcc tgttggctta acgtcactgt tccacccggt gtaatatctc tcatgacagt   5220

gacaccaagg gaagttgact aagtcacatg taaattagga gtgttttaaa gaatgccata   5280

gatgttgatt cttaactgct acagataacc tgtaattgag cagatttaaa attcaggcat   5340

acttttccat ttatccaagt gctttcattt ttccagatgg cttcagaagt aggctcgtgg   5400

gcagggcgca gacctgatct ttatagggtt gacatagaaa gcagtagttg tgggtgaaag   5460

ggcaggttgt cttcaaactc tgtgaggtag aatcctttgt ctatacctcc atgaacattg   5520

actcgtgtgt tcagagcctt tggcctctct gtggagtctg gctctctggc tcctgtgcat   5580

tctttgaata gtcactcgta aaaactgtca gtgcttgaaa ctgtttcctt tactcatgtt   5640

gaagggactt tgttggcttt tagagtgttg gtcatgactc caagagcaga gcagggaaga   5700

gcccaagcat agacttggtg ccgtggtgat ggctgcagtc cagttttgtg atgctgcttt   5760

tacgtgtccc tcgataacag tcagctagac acactcagga ggactactga ggctctgcga   5820

ccttcaggag ctgagcctgc ctctctcctt tagatgacag accttcatct gggaacgtgc   5880

tgagccagca ccctcagatg atttccctcc aaactgctga ctaggtcatc ctctgtctgg   5940

tagagacatt cacatctttg cttttattct atgctctctg tacttttgac caaaaattga   6000

ccaaagtaag aaaatgcaag ttctaaaaat agactaagga tgcctttgca gaacaccaaa   6060

gcatcccaag gaactggtag ggaagtggcg cctgtctcct ggagtggaag aggcctgctc   6120

cctggctctg ggtctgctgg gggcacagta aatcagtctt ggcacccaca tccagggcag   6180

agaggtctgt ggttctcagc atcagaaggc agcgcagccc ctctcctctt caggctacag   6240

ggttgtcacc tgctgagtcc tcaggttgtt tggcctctct ggtccatctt gggcattagg   6300

ttctccagca gagctctggc cagctgcctc ttctttaact gggaacacag gctctcacaa   6360

gatcagaacc cccactcacc cccaagatct tatctagcaa gcctgtagta ttcagtttct   6420

gttgtaggaa gagagcgagg catccctgaa ttccacgcat ctgctggaaa cgagccgtgt   6480

cagatcgcac atccctgcgc ccccatgccc ctctgagtca cacaggacag aggaggcaga   6540

gcttctgccc actgttatct tcactttctt tgtccagtct tttgttttta ataagcagtg   6600

accctcccta ctcttctttt taatgatttt tgtagttgat ttgtctgaac tgtggctact   6660

gtgcattcct tgaataatca cttgtaaaaa ttgtcagtgc ttgaagctgt ttcctttact   6720

cacattgaag ggacttcgtt ggttttttgg agtcttggtt gtgactccaa gagcagagtg   6780

aggaagaccc ccaagcatag actcgggtac tgtgatgatg gctgcagtcc agttttatga   6840

ttctgctttt atgtgtccct tgataacagt gacttaacaa tatacattcc tcataaataa   6900

aaaaaaaaca agaatctgaa ttcttagaaa                                    6930


<210>  1241
<211>  1181
<212>  PRT
<213>  Homo sapiens

<400>  1241


Met Asn Pro Arg Gln Gly Tyr Ser Leu Ser Gly Tyr Tyr Thr His Pro 
1               5                   10                  15      


Phe Gln Gly Tyr Glu His Arg Gln Leu Arg Tyr Gln Gln Pro Gly Pro 
            20                  25                  30          


Gly Ser Ser Pro Ser Ser Phe Leu Leu Lys Gln Ile Glu Phe Leu Lys 
        35                  40                  45              


Gly Gln Leu Pro Glu Ala Pro Val Ile Gly Lys Gln Thr Pro Ser Leu 
    50                  55                  60                  


Pro Pro Ser Leu Pro Gly Leu Arg Pro Arg Phe Pro Val Leu Leu Ala 
65                  70                  75                  80  


Ser Ser Thr Arg Gly Arg Gln Val Asp Ile Arg Gly Val Pro Arg Gly 
                85                  90                  95      


Val His Leu Arg Ser Gln Gly Leu Gln Arg Gly Phe Gln His Pro Ser 
            100                 105                 110         


Pro Arg Gly Arg Ser Leu Pro Gln Arg Gly Val Asp Cys Leu Ser Ser 
        115                 120                 125             


His Phe Gln Glu Leu Ser Ile Tyr Gln Asp Gln Glu Gln Arg Ile Leu 
    130                 135                 140                 


Lys Phe Leu Glu Glu Leu Gly Glu Gly Lys Ala Thr Thr Ala His Asp 
145                 150                 155                 160 


Leu Ser Gly Lys Leu Gly Thr Pro Lys Lys Glu Ile Asn Arg Val Leu 
                165                 170                 175     


Tyr Ser Leu Ala Lys Lys Gly Lys Leu Gln Lys Glu Ala Gly Thr Pro 
            180                 185                 190         


Pro Leu Trp Lys Ile Ala Val Ser Thr Gln Ala Trp Asn Gln His Ser 
        195                 200                 205             


Gly Val Val Arg Pro Asp Gly His Ser Gln Gly Ala Pro Asn Ser Asp 
    210                 215                 220                 


Pro Ser Leu Glu Pro Glu Asp Arg Asn Ser Thr Ser Val Ser Glu Asp 
225                 230                 235                 240 


Leu Leu Glu Pro Phe Ile Ala Val Ser Ala Gln Ala Trp Asn Gln His 
                245                 250                 255     


Ser Gly Val Val Arg Pro Asp Ser His Ser Gln Gly Ser Pro Asn Ser 
            260                 265                 270         


Asp Pro Gly Leu Glu Pro Glu Asp Ser Asn Ser Thr Ser Ala Leu Glu 
        275                 280                 285             


Asp Pro Leu Glu Phe Leu Asp Met Ala Glu Ile Lys Glu Lys Ile Cys 
    290                 295                 300                 


Asp Tyr Leu Phe Asn Val Ser Asp Ser Ser Ala Leu Asn Leu Ala Lys 
305                 310                 315                 320 


Asn Ile Gly Leu Thr Lys Ala Arg Asp Ile Asn Ala Val Leu Ile Asp 
                325                 330                 335     


Met Glu Arg Gln Gly Asp Val Tyr Arg Gln Gly Thr Thr Pro Pro Ile 
            340                 345                 350         


Trp His Leu Thr Asp Lys Lys Arg Glu Arg Met Gln Ile Lys Arg Asn 
        355                 360                 365             


Thr Asn Ser Val Pro Glu Thr Ala Pro Ala Ala Ile Pro Glu Thr Lys 
    370                 375                 380                 


Arg Asn Ala Glu Phe Leu Thr Cys Asn Ile Pro Thr Ser Asn Ala Ser 
385                 390                 395                 400 


Asn Asn Met Val Thr Thr Glu Lys Val Glu Asn Gly Gln Glu Pro Val 
                405                 410                 415     


Ile Lys Leu Glu Asn Arg Gln Glu Ala Arg Pro Glu Pro Ala Arg Leu 
            420                 425                 430         


Lys Pro Pro Val His Tyr Asn Gly Pro Ser Lys Ala Gly Tyr Val Asp 
        435                 440                 445             


Phe Glu Asn Gly Gln Trp Ala Thr Asp Asp Ile Pro Asp Asp Leu Asn 
    450                 455                 460                 


Ser Ile Arg Ala Ala Pro Gly Glu Phe Arg Ala Ile Met Glu Met Pro 
465                 470                 475                 480 


Ser Phe Tyr Ser His Gly Leu Pro Arg Cys Ser Pro Tyr Lys Lys Leu 
                485                 490                 495     


Thr Glu Cys Gln Leu Lys Asn Pro Ile Ser Gly Leu Leu Glu Tyr Ala 
            500                 505                 510         


Gln Phe Ala Ser Gln Thr Cys Glu Phe Asn Met Ile Glu Gln Ser Gly 
        515                 520                 525             


Pro Pro His Glu Pro Arg Phe Lys Phe Gln Val Val Ile Asn Gly Arg 
    530                 535                 540                 


Glu Phe Pro Pro Ala Glu Ala Gly Ser Lys Lys Val Ala Lys Gln Asp 
545                 550                 555                 560 


Ala Ala Met Lys Ala Met Thr Ile Leu Leu Glu Glu Ala Lys Ala Lys 
                565                 570                 575     


Asp Ser Gly Lys Ser Glu Glu Ser Ser His Tyr Ser Thr Glu Lys Glu 
            580                 585                 590         


Ser Glu Lys Thr Ala Glu Ser Gln Thr Pro Thr Pro Ser Ala Thr Ser 
        595                 600                 605             


Phe Phe Ser Gly Lys Ser Pro Val Thr Thr Leu Leu Glu Cys Met His 
    610                 615                 620                 


Lys Leu Gly Asn Ser Cys Glu Phe Arg Leu Leu Ser Lys Glu Gly Pro 
625                 630                 635                 640 


Ala His Glu Pro Lys Phe Gln Tyr Cys Val Ala Val Gly Ala Gln Thr 
                645                 650                 655     


Phe Pro Ser Val Ser Ala Pro Ser Lys Lys Val Ala Lys Gln Met Ala 
            660                 665                 670         


Ala Glu Glu Ala Met Lys Ala Leu His Gly Glu Ala Thr Asn Ser Met 
        675                 680                 685             


Ala Ser Asp Asn Gln Val Arg Lys Ile Gly Glu Leu Val Arg Tyr Leu 
    690                 695                 700                 


Asn Thr Asn Pro Val Gly Gly Leu Leu Glu Tyr Ala Arg Ser His Gly 
705                 710                 715                 720 


Phe Ala Ala Glu Phe Lys Leu Val Asp Gln Ser Gly Pro Pro His Glu 
                725                 730                 735     


Pro Lys Phe Val Tyr Gln Ala Lys Val Gly Gly Arg Trp Phe Pro Ala 
            740                 745                 750         


Val Cys Ala His Ser Lys Lys Gln Gly Lys Gln Glu Ala Ala Asp Ala 
        755                 760                 765             


Ala Leu Arg Val Leu Ile Gly Glu Asn Glu Lys Ala Glu Arg Met Gly 
    770                 775                 780                 


Phe Thr Glu Leu Pro Leu Thr Gly Ser Thr Phe His Asp Gln Ile Ala 
785                 790                 795                 800 


Met Leu Ser His Arg Cys Phe Asn Thr Leu Thr Asn Ser Phe Gln Pro 
                805                 810                 815     


Ser Leu Leu Gly Arg Lys Ile Leu Ala Ala Ile Ile Met Lys Lys Asp 
            820                 825                 830         


Ser Glu Asp Met Gly Val Val Val Ser Leu Gly Thr Gly Asn Arg Cys 
        835                 840                 845             


Val Lys Gly Asp Ser Leu Ser Leu Lys Gly Glu Thr Val Asn Asp Cys 
    850                 855                 860                 


His Ala Glu Ile Ile Ser Arg Arg Gly Phe Ile Arg Phe Leu Tyr Ser 
865                 870                 875                 880 


Glu Leu Met Lys Tyr Asn Ser Gln Thr Ala Lys Asp Ser Ile Phe Glu 
                885                 890                 895     


Pro Ala Lys Gly Gly Glu Lys Leu Gln Ile Lys Lys Thr Val Ser Phe 
            900                 905                 910         


His Leu Tyr Ile Ser Thr Ala Pro Cys Gly Asp Gly Ala Leu Phe Asp 
        915                 920                 925             


Lys Ser Cys Ser Asp Arg Ala Met Glu Ser Thr Glu Ser Arg His Tyr 
    930                 935                 940                 


Pro Val Phe Glu Asn Pro Lys Gln Gly Lys Leu Arg Thr Lys Val Glu 
945                 950                 955                 960 


Asn Gly Glu Gly Thr Ile Pro Val Glu Ser Ser Asp Ile Val Pro Thr 
                965                 970                 975     


Trp Asp Gly Ile Arg Leu Gly Glu Arg Leu Arg Thr Met Ser Cys Ser 
            980                 985                 990         


Asp Lys Ile Leu Arg Trp Asn Val  Leu Gly Leu Gln Gly  Ala Leu Leu 
        995                 1000                 1005             


Thr His  Phe Leu Gln Pro Ile  Tyr Leu Lys Ser Val  Thr Leu Gly 
    1010                 1015                 1020             


Tyr Leu  Phe Ser Gln Gly His  Leu Thr Arg Ala Ile  Cys Cys Arg 
    1025                 1030                 1035             


Val Thr  Arg Asp Gly Ser Ala  Phe Glu Asp Gly Leu  Arg His Pro 
    1040                 1045                 1050             


Phe Ile  Val Asn His Pro Lys  Val Gly Arg Val Ser  Ile Tyr Asp 
    1055                 1060                 1065             


Ser Lys  Arg Gln Ser Gly Lys  Thr Lys Glu Thr Ser  Val Asn Trp 
    1070                 1075                 1080             


Cys Leu  Ala Asp Gly Tyr Asp  Leu Glu Ile Leu Asp  Gly Thr Arg 
    1085                 1090                 1095             


Gly Thr  Val Asp Gly Pro Arg  Asn Glu Leu Ser Arg  Val Ser Lys 
    1100                 1105                 1110             


Lys Asn  Ile Phe Leu Leu Phe  Lys Lys Leu Cys Ser  Phe Arg Tyr 
    1115                 1120                 1125             


Arg Arg  Asp Leu Leu Arg Leu  Ser Tyr Gly Glu Ala  Lys Lys Ala 
    1130                 1135                 1140             


Ala Arg  Asp Tyr Glu Thr Ala  Lys Asn Tyr Phe Lys  Lys Gly Leu 
    1145                 1150                 1155             


Lys Asp  Met Gly Tyr Gly Asn  Trp Ile Ser Lys Pro  Gln Glu Glu 
    1160                 1165                 1170             


Lys Asn  Phe Tyr Leu Cys Pro  Val 
    1175                 1180     

<210>  1242
<211>  6987
<212>  DNA
<213>  Homo sapiens

<400>  1242
ggacgggcgc gggggctgac gcctgtaatc ccaacacttt gggaggccga ggtgggcgga     60

tctcttgaag ccgggagttc gagaccaccc tggctaacgt ggtgaaaccc tgttcttact    120

aaaaatacaa aaaaaaaaaa aaaaaaaaag ccaggagtga tggcgctcgc ctgtaatccc    180

agctactccg taggctgagg caggagaatc gcttgaaccc ggggggcaga ggttgcagtg    240

agccgagatt gcgccattgc actccagcct gggcaaaaag agcgagactc cgcctcaaaa    300

aaaaaaaaaa aagtaccttc cgtagttctc atgcagcgga ggggttcgac ttgtaaccgg    360

cctgaaacca agcgtggcgc aagatttgct caagcccctc ctcttggcca aactttccgg    420

aggggaaggc tttccgagga aacgaaagcg aaattgaacc ggagccatct tgggcccggc    480

gcgcagaccc gcggagtttc ccgtgccgac gccccggggc cacttccagt gcggagtagc    540

ggaggcgtgg gggcctcgag gggctggcgc ggcccagcgg tcgggccagg gtcgtgccgc    600

cggcgggtcg ggccgggcaa tgcctcgcgg gcgcaatgaa tccgcggcag gggtattccc    660

tcagcggata ctacacccat ccatttcaag gctatgagca cagacagctc aggtaccagc    720

agcctgggcc aggatcttcc cccagtagtt tcctgcttaa gcaaatagaa tttctcaagg    780

ggcagctccc agaagcaccg gtgattggaa agcagacacc gtcactgcca ccttccctcc    840

caggactccg gccaaggttt ccagtactac ttgcctccag taccagaggc aggcaagtgg    900

acatcagggg tgtccccagg ggcgtgcatc tcagaagtca ggggctccag agagggttcc    960

agcatccttc accacgtggc aggagtctgc cacagagagg tgttgattgc ctttcctcac   1020

atttccagga actgagtatc taccaagatc aggaacaaag gatcttaaag ttcctggaag   1080

agcttgggga agggaaggcc accacagcac atgatctgtc tgggaaactt gggactccga   1140

agaaagaaat caatcgagtt ttatactccc tggcaaagaa gggcaagcta cagaaagagg   1200

caggaacacc ccctttgtgg aaaatcgcgg tctccactca ggcttggaac cagcacagcg   1260

gagtggtaag accagacggt catagccaag gagccccaaa ctcagacccg agtttggaac   1320

cggaagacag aaactccaca tctgtctcag aagatcttct tgagcctttt attgcagtct   1380

cagctcaggc ttggaaccag cacagcggag tggtaagacc agacagtcat agccaaggat   1440

ccccaaactc agacccaggt ttggaacctg aagacagcaa ctccacatct gccttggaag   1500

atcctcttga gtttttagac atggccgaga tcaaggagaa aatctgcgac tatctcttca   1560

atgtgtctga ctcctctgcc ctgaatttgg ctaaaaatat tggccttacc aaggcccgag   1620

atataaatgc tgtgctaatt gacatggaaa ggcaggggga tgtctataga caagggacaa   1680

cccctcccat atggcatttg acagacaaga agcgagagag gatgcaaatc aagagaaata   1740

cgaacagtgt tcctgaaacc gctccagctg caatccctga gaccaaaaga aacgcagagt   1800

tcctcacctg taatataccc acatcaaatg cctcaaataa catggtaacc acagaaaaag   1860

tggagaatgg gcaggaacct gtcataaagt tagaaaacag gcaagaggcc agaccagaac   1920

cagcaagact gaaaccacct gttcattaca atggcccctc aaaagcaggg tatgttgact   1980

ttgaaaatgg ccagtgggcc acagatgaca tcccagatga cttgaatagt atccgcgcag   2040

caccaggtga gtttcgagcc atcatggaga tgccctcctt ctacagtcat ggcttgccac   2100

ggtgttcacc ctacaagaaa ctgacagagt gccagctgaa gaaccccatc agcgggctgt   2160

tagaatatgc ccagttcgct agtcaaacct gtgagttcaa catgatagag cagagtggac   2220

caccccatga acctcgattt aaattccagg ttgtcatcaa tggccgagag tttcccccag   2280

ctgaagctgg aagcaagaaa gtggccaagc aggatgcagc tatgaaagcc atgacaattc   2340

tgctagagga agccaaagcc aaggacagtg gaaaatcaga agaatcatcc cactattcca   2400

cagagaaaga atcagagaag actgcagagt cccagacccc caccccttca gccacatcct   2460

tcttttctgg gaagagcccc gtcaccacac tgcttgagtg tatgcacaaa ttggggaact   2520

cctgcgaatt ccgtctcctg tccaaagaag gccctgccca tgaacccaag ttccaatact   2580

gtgttgcagt gggagcccaa actttcccca gtgtgagtgc tcccagcaag aaagtggcaa   2640

agcagatggc cgcagaggaa gccatgaagg ccctgcatgg ggaggcgacc aactccatgg   2700

cttctgataa ccagcctgaa ggtatgatct cagagtcact tgataacttg gaatccatga   2760

tgcccaacaa ggtcaggaag attggcgagc tcgtgagata cctgaacacc aaccctgtgg   2820

gtggcctttt ggagtacgcc cgctcccatg gctttgctgc tgaattcaag ttggtcgacc   2880

agtccggacc tcctcacgag cccaagttcg tttaccaagc aaaagttggg ggtcgctggt   2940

tcccagccgt ctgcgcacac agcaagaagc aaggcaagca ggaagcagca gatgcggctc   3000

tccgtgtctt gattggggag aacgagaagg cagaacgcat gggtttcaca gagctccctc   3060

tcactggcag caccttccat gaccagatag ccatgctgag ccaccggtgc ttcaacactc   3120

tgactaacag cttccagccc tccttgctcg gccgcaagat tctggccgcc atcattatga   3180

aaaaagactc tgaggacatg ggtgtcgtcg tcagcttggg aacagggaat cgctgtgtga   3240

aaggagattc tctcagccta aaaggagaaa ctgtcaatga ctgccatgca gaaataatct   3300

cccggagagg cttcatcagg tttctctaca gtgagttaat gaaatacaac tcccagactg   3360

cgaaggatag tatatttgaa cctgctaagg gaggagaaaa gctccaaata aaaaagactg   3420

tgtcattcca tctgtatatc agcactgctc cgtgtggaga tggcgccctc tttgacaagt   3480

cctgcagcga ccgtgctatg gaaagcacag aatcccgcca ctaccctgtc ttcgagaatc   3540

ccaaacaagg aaagctccgc accaaggtgg agaacggaga aggcacaatc cctgtggaat   3600

ccagtgacat tgtgcctacg tgggatggca ttcggctcgg ggagagactc cgtaccatgt   3660

cctgtagtga caaaatccta cgctggaacg tgctgggcct gcaaggggca ctgttgaccc   3720

acttcctgca gcccatttat ctcaaatctg tcacattggg ttaccttttc agccaagggc   3780

atctgacccg tgctatttgc tgtcgtgtga caagagatgg gagtgcattt gaggatggac   3840

tacgacatcc ctttattgtc aaccacccca aggttggcag agtcagcata tatgattcca   3900

aaaggcaatc cgggaagact aaggagacaa gcgtcaactg gtgtctggct gatggctatg   3960

acctggagat cctggacggt accagaggca ctgtggatgg gccacggaat gaattgtccc   4020

gggtctccaa aaagaacatt tttcttctat ttaagaagct ctgctccttc cgttaccgca   4080

gggatctact gagactctcc tatggtgagg ccaagaaagc tgcccgtgac tacgagacgg   4140

ccaagaacta cttcaaaaaa ggcctgaagg atatgggcta tgggaactgg attagcaaac   4200

cccaggagga aaagaacttt tatctctgcc cagtatagta tgctccagtg acagatggat   4260

tagggtgtgt catactaggg tgtgagagag gtaggtcgta gcattcctca tcacatggtc   4320

aggggatttt tttttctcct ttttttttct ttttaagcca taattggtga tactgaaaac   4380

tttgggttcc catttatcct gctttctttg ggattgctag gcaaggtctg gccaggcccc   4440

ccttttttcc cccaagtgaa gaggcagaaa cctaagaagt tatcttttct ttctacccaa   4500

agcatacata gtcactgagc acctgcggtc catttcctct taaaagtttt gttttgattt   4560

gtttccattt cctttccctt tgtgtttgct acactgacct cttgcggtct tgattaggtt   4620

tcagtcaact ctggatcatg tcagggactg ataatttcat ttgtggatta cgcagacccc   4680

tctacttccc ctctttccct tctgagattc tttccttgtg atctgaatgt ctccttttcc   4740

ccctcagagg gcaaagaggt gaacataaag gatttggtga aacatttgta agggtaggag   4800

ttgaaaactg cagttcccag tgccacggaa gtgtgattgg agcctgcaga taatgcccag   4860

ccatcctccc atcctgcact ttagccagct gcagggcggg caaggcaagg aaagctgctt   4920

ccctggaagt gtatcacttt ctccggcagc tgggaagtct agaaccagcc agactgggtt   4980

aagggagctg ctcaagcaat agcagaggtt tcacccggca ggatgacaca gaccacttcc   5040

cagggagcac gggcatgcct tggaatattg ccaagcttcc agctgcctct tctcctaaag   5100

cattcctagg aatattttcc ccgccaatgc tgggcgtaca ccctagccaa cgggacaaat   5160

cctagagggt ataaaatcat ctctgctcag ataatcatga cttagcaaga ataagggcaa   5220

aaaatcctgt tggcttaacg tcactgttcc acccggtgta atatctctca tgacagtgac   5280

accaagggaa gttgactaag tcacatgtaa attaggagtg ttttaaagaa tgccatagat   5340

gttgattctt aactgctaca gataacctgt aattgagcag atttaaaatt caggcatact   5400

tttccattta tccaagtgct ttcatttttc cagatggctt cagaagtagg ctcgtgggca   5460

gggcgcagac ctgatcttta tagggttgac atagaaagca gtagttgtgg gtgaaagggc   5520

aggttgtctt caaactctgt gaggtagaat cctttgtcta tacctccatg aacattgact   5580

cgtgtgttca gagcctttgg cctctctgtg gagtctggct ctctggctcc tgtgcattct   5640

ttgaatagtc actcgtaaaa actgtcagtg cttgaaactg tttcctttac tcatgttgaa   5700

gggactttgt tggcttttag agtgttggtc atgactccaa gagcagagca gggaagagcc   5760

caagcataga cttggtgccg tggtgatggc tgcagtccag ttttgtgatg ctgcttttac   5820

gtgtccctcg ataacagtca gctagacaca ctcaggagga ctactgaggc tctgcgacct   5880

tcaggagctg agcctgcctc tctcctttag atgacagacc ttcatctggg aacgtgctga   5940

gccagcaccc tcagatgatt tccctccaaa ctgctgacta ggtcatcctc tgtctggtag   6000

agacattcac atctttgctt ttattctatg ctctctgtac ttttgaccaa aaattgacca   6060

aagtaagaaa atgcaagttc taaaaataga ctaaggatgc ctttgcagaa caccaaagca   6120

tcccaaggaa ctggtaggga agtggcgcct gtctcctgga gtggaagagg cctgctccct   6180

ggctctgggt ctgctggggg cacagtaaat cagtcttggc acccacatcc agggcagaga   6240

ggtctgtggt tctcagcatc agaaggcagc gcagcccctc tcctcttcag gctacagggt   6300

tgtcacctgc tgagtcctca ggttgtttgg cctctctggt ccatcttggg cattaggttc   6360

tccagcagag ctctggccag ctgcctcttc tttaactggg aacacaggct ctcacaagat   6420

cagaaccccc actcaccccc aagatcttat ctagcaagcc tgtagtattc agtttctgtt   6480

gtaggaagag agcgaggcat ccctgaattc cacgcatctg ctggaaacga gccgtgtcag   6540

atcgcacatc cctgcgcccc catgcccctc tgagtcacac aggacagagg aggcagagct   6600

tctgcccact gttatcttca ctttctttgt ccagtctttt gtttttaata agcagtgacc   6660

ctccctactc ttctttttaa tgatttttgt agttgatttg tctgaactgt ggctactgtg   6720

cattccttga ataatcactt gtaaaaattg tcagtgcttg aagctgtttc ctttactcac   6780

attgaaggga cttcgttggt tttttggagt cttggttgtg actccaagag cagagtgagg   6840

aagaccccca agcatagact cgggtactgt gatgatggct gcagtccagt tttatgattc   6900

tgcttttatg tgtcccttga taacagtgac ttaacaatat acattcctca taaataaaaa   6960

aaaaacaaga atctgaattc ttagaaa                                       6987


<210>  1243
<211>  1200
<212>  PRT
<213>  Homo sapiens

<400>  1243


Met Asn Pro Arg Gln Gly Tyr Ser Leu Ser Gly Tyr Tyr Thr His Pro 
1               5                   10                  15      


Phe Gln Gly Tyr Glu His Arg Gln Leu Arg Tyr Gln Gln Pro Gly Pro 
            20                  25                  30          


Gly Ser Ser Pro Ser Ser Phe Leu Leu Lys Gln Ile Glu Phe Leu Lys 
        35                  40                  45              


Gly Gln Leu Pro Glu Ala Pro Val Ile Gly Lys Gln Thr Pro Ser Leu 
    50                  55                  60                  


Pro Pro Ser Leu Pro Gly Leu Arg Pro Arg Phe Pro Val Leu Leu Ala 
65                  70                  75                  80  


Ser Ser Thr Arg Gly Arg Gln Val Asp Ile Arg Gly Val Pro Arg Gly 
                85                  90                  95      


Val His Leu Arg Ser Gln Gly Leu Gln Arg Gly Phe Gln His Pro Ser 
            100                 105                 110         


Pro Arg Gly Arg Ser Leu Pro Gln Arg Gly Val Asp Cys Leu Ser Ser 
        115                 120                 125             


His Phe Gln Glu Leu Ser Ile Tyr Gln Asp Gln Glu Gln Arg Ile Leu 
    130                 135                 140                 


Lys Phe Leu Glu Glu Leu Gly Glu Gly Lys Ala Thr Thr Ala His Asp 
145                 150                 155                 160 


Leu Ser Gly Lys Leu Gly Thr Pro Lys Lys Glu Ile Asn Arg Val Leu 
                165                 170                 175     


Tyr Ser Leu Ala Lys Lys Gly Lys Leu Gln Lys Glu Ala Gly Thr Pro 
            180                 185                 190         


Pro Leu Trp Lys Ile Ala Val Ser Thr Gln Ala Trp Asn Gln His Ser 
        195                 200                 205             


Gly Val Val Arg Pro Asp Gly His Ser Gln Gly Ala Pro Asn Ser Asp 
    210                 215                 220                 


Pro Ser Leu Glu Pro Glu Asp Arg Asn Ser Thr Ser Val Ser Glu Asp 
225                 230                 235                 240 


Leu Leu Glu Pro Phe Ile Ala Val Ser Ala Gln Ala Trp Asn Gln His 
                245                 250                 255     


Ser Gly Val Val Arg Pro Asp Ser His Ser Gln Gly Ser Pro Asn Ser 
            260                 265                 270         


Asp Pro Gly Leu Glu Pro Glu Asp Ser Asn Ser Thr Ser Ala Leu Glu 
        275                 280                 285             


Asp Pro Leu Glu Phe Leu Asp Met Ala Glu Ile Lys Glu Lys Ile Cys 
    290                 295                 300                 


Asp Tyr Leu Phe Asn Val Ser Asp Ser Ser Ala Leu Asn Leu Ala Lys 
305                 310                 315                 320 


Asn Ile Gly Leu Thr Lys Ala Arg Asp Ile Asn Ala Val Leu Ile Asp 
                325                 330                 335     


Met Glu Arg Gln Gly Asp Val Tyr Arg Gln Gly Thr Thr Pro Pro Ile 
            340                 345                 350         


Trp His Leu Thr Asp Lys Lys Arg Glu Arg Met Gln Ile Lys Arg Asn 
        355                 360                 365             


Thr Asn Ser Val Pro Glu Thr Ala Pro Ala Ala Ile Pro Glu Thr Lys 
    370                 375                 380                 


Arg Asn Ala Glu Phe Leu Thr Cys Asn Ile Pro Thr Ser Asn Ala Ser 
385                 390                 395                 400 


Asn Asn Met Val Thr Thr Glu Lys Val Glu Asn Gly Gln Glu Pro Val 
                405                 410                 415     


Ile Lys Leu Glu Asn Arg Gln Glu Ala Arg Pro Glu Pro Ala Arg Leu 
            420                 425                 430         


Lys Pro Pro Val His Tyr Asn Gly Pro Ser Lys Ala Gly Tyr Val Asp 
        435                 440                 445             


Phe Glu Asn Gly Gln Trp Ala Thr Asp Asp Ile Pro Asp Asp Leu Asn 
    450                 455                 460                 


Ser Ile Arg Ala Ala Pro Gly Glu Phe Arg Ala Ile Met Glu Met Pro 
465                 470                 475                 480 


Ser Phe Tyr Ser His Gly Leu Pro Arg Cys Ser Pro Tyr Lys Lys Leu 
                485                 490                 495     


Thr Glu Cys Gln Leu Lys Asn Pro Ile Ser Gly Leu Leu Glu Tyr Ala 
            500                 505                 510         


Gln Phe Ala Ser Gln Thr Cys Glu Phe Asn Met Ile Glu Gln Ser Gly 
        515                 520                 525             


Pro Pro His Glu Pro Arg Phe Lys Phe Gln Val Val Ile Asn Gly Arg 
    530                 535                 540                 


Glu Phe Pro Pro Ala Glu Ala Gly Ser Lys Lys Val Ala Lys Gln Asp 
545                 550                 555                 560 


Ala Ala Met Lys Ala Met Thr Ile Leu Leu Glu Glu Ala Lys Ala Lys 
                565                 570                 575     


Asp Ser Gly Lys Ser Glu Glu Ser Ser His Tyr Ser Thr Glu Lys Glu 
            580                 585                 590         


Ser Glu Lys Thr Ala Glu Ser Gln Thr Pro Thr Pro Ser Ala Thr Ser 
        595                 600                 605             


Phe Phe Ser Gly Lys Ser Pro Val Thr Thr Leu Leu Glu Cys Met His 
    610                 615                 620                 


Lys Leu Gly Asn Ser Cys Glu Phe Arg Leu Leu Ser Lys Glu Gly Pro 
625                 630                 635                 640 


Ala His Glu Pro Lys Phe Gln Tyr Cys Val Ala Val Gly Ala Gln Thr 
                645                 650                 655     


Phe Pro Ser Val Ser Ala Pro Ser Lys Lys Val Ala Lys Gln Met Ala 
            660                 665                 670         


Ala Glu Glu Ala Met Lys Ala Leu His Gly Glu Ala Thr Asn Ser Met 
        675                 680                 685             


Ala Ser Asp Asn Gln Pro Glu Gly Met Ile Ser Glu Ser Leu Asp Asn 
    690                 695                 700                 


Leu Glu Ser Met Met Pro Asn Lys Val Arg Lys Ile Gly Glu Leu Val 
705                 710                 715                 720 


Arg Tyr Leu Asn Thr Asn Pro Val Gly Gly Leu Leu Glu Tyr Ala Arg 
                725                 730                 735     


Ser His Gly Phe Ala Ala Glu Phe Lys Leu Val Asp Gln Ser Gly Pro 
            740                 745                 750         


Pro His Glu Pro Lys Phe Val Tyr Gln Ala Lys Val Gly Gly Arg Trp 
        755                 760                 765             


Phe Pro Ala Val Cys Ala His Ser Lys Lys Gln Gly Lys Gln Glu Ala 
    770                 775                 780                 


Ala Asp Ala Ala Leu Arg Val Leu Ile Gly Glu Asn Glu Lys Ala Glu 
785                 790                 795                 800 


Arg Met Gly Phe Thr Glu Leu Pro Leu Thr Gly Ser Thr Phe His Asp 
                805                 810                 815     


Gln Ile Ala Met Leu Ser His Arg Cys Phe Asn Thr Leu Thr Asn Ser 
            820                 825                 830         


Phe Gln Pro Ser Leu Leu Gly Arg Lys Ile Leu Ala Ala Ile Ile Met 
        835                 840                 845             


Lys Lys Asp Ser Glu Asp Met Gly Val Val Val Ser Leu Gly Thr Gly 
    850                 855                 860                 


Asn Arg Cys Val Lys Gly Asp Ser Leu Ser Leu Lys Gly Glu Thr Val 
865                 870                 875                 880 


Asn Asp Cys His Ala Glu Ile Ile Ser Arg Arg Gly Phe Ile Arg Phe 
                885                 890                 895     


Leu Tyr Ser Glu Leu Met Lys Tyr Asn Ser Gln Thr Ala Lys Asp Ser 
            900                 905                 910         


Ile Phe Glu Pro Ala Lys Gly Gly Glu Lys Leu Gln Ile Lys Lys Thr 
        915                 920                 925             


Val Ser Phe His Leu Tyr Ile Ser Thr Ala Pro Cys Gly Asp Gly Ala 
    930                 935                 940                 


Leu Phe Asp Lys Ser Cys Ser Asp Arg Ala Met Glu Ser Thr Glu Ser 
945                 950                 955                 960 


Arg His Tyr Pro Val Phe Glu Asn Pro Lys Gln Gly Lys Leu Arg Thr 
                965                 970                 975     


Lys Val Glu Asn Gly Glu Gly Thr Ile Pro Val Glu Ser Ser Asp Ile 
            980                 985                 990         


Val Pro Thr Trp Asp Gly Ile Arg  Leu Gly Glu Arg Leu  Arg Thr Met 
        995                 1000                 1005             


Ser Cys  Ser Asp Lys Ile Leu  Arg Trp Asn Val Leu  Gly Leu Gln 
    1010                 1015                 1020             


Gly Ala  Leu Leu Thr His Phe  Leu Gln Pro Ile Tyr  Leu Lys Ser 
    1025                 1030                 1035             


Val Thr  Leu Gly Tyr Leu Phe  Ser Gln Gly His Leu  Thr Arg Ala 
    1040                 1045                 1050             


Ile Cys  Cys Arg Val Thr Arg  Asp Gly Ser Ala Phe  Glu Asp Gly 
    1055                 1060                 1065             


Leu Arg  His Pro Phe Ile Val  Asn His Pro Lys Val  Gly Arg Val 
    1070                 1075                 1080             


Ser Ile  Tyr Asp Ser Lys Arg  Gln Ser Gly Lys Thr  Lys Glu Thr 
    1085                 1090                 1095             


Ser Val  Asn Trp Cys Leu Ala  Asp Gly Tyr Asp Leu  Glu Ile Leu 
    1100                 1105                 1110             


Asp Gly  Thr Arg Gly Thr Val  Asp Gly Pro Arg Asn  Glu Leu Ser 
    1115                 1120                 1125             


Arg Val  Ser Lys Lys Asn Ile  Phe Leu Leu Phe Lys  Lys Leu Cys 
    1130                 1135                 1140             


Ser Phe  Arg Tyr Arg Arg Asp  Leu Leu Arg Leu Ser  Tyr Gly Glu 
    1145                 1150                 1155             


Ala Lys  Lys Ala Ala Arg Asp  Tyr Glu Thr Ala Lys  Asn Tyr Phe 
    1160                 1165                 1170             


Lys Lys  Gly Leu Lys Asp Met  Gly Tyr Gly Asn Trp  Ile Ser Lys 
    1175                 1180                 1185             


Pro Gln  Glu Glu Lys Asn Phe  Tyr Leu Cys Pro Val  
    1190                 1195                 1200 

<210>  1244
<211>  7065
<212>  DNA
<213>  Homo sapiens

<400>  1244
ggacgggcgc gggggctgac gcctgtaatc ccaacacttt gggaggccga ggtgggcgga     60

tctcttgaag ccgggagttc gagaccaccc tggctaacgt ggtgaaaccc tgttcttact    120

aaaaatacaa aaaaaaaaaa aaaaaaaaag ccaggagtga tggcgctcgc ctgtaatccc    180

agctactccg taggctgagg caggagaatc gcttgaaccc ggggggcaga ggttgcagtg    240

agccgagatt gcgccattgc actccagcct gggcaaaaag agcgagactc cgcctcaaaa    300

aaaaaaaaaa aagtaccttc cgtagttctc atgcagcgga ggggttcgac ttgtaaccgg    360

cctgaaacca agcgtggcgc aagatttgct caagcccctc ctcttggcca aactttccgg    420

aggggaaggc tttccgagga aacgaaagcg aaattgaacc ggagccatct tgggcccggc    480

gcgcagaccc gcggagtttc ccgtgccgac gccccggggc cacttccagt gcggagtagc    540

ggaggcgtgg gggcctcgag gggctggcgc ggcccagcgg tcgggccagg gtcgtgccgc    600

cggcgggtcg ggccgggcaa tgcctcgcgg gcgcaatgaa tccgcggcag gggtattccc    660

tcagcggata ctacacccat ccatttcaag gctatgagca cagacagctc aggtaccagc    720

agcctgggcc aggatcttcc cccagtagtt tcctgcttaa gcaaatagaa tttctcaagg    780

ggcagctccc agaagcaccg gtgattggaa agcagacacc gtcactgcca ccttccctcc    840

caggactccg gccaaggttt ccagtactac ttgcctccag taccagaggc aggcaagtgg    900

acatcagggg tgtccccagg ggcgtgcatc tcagaagtca ggggctccag agagggttcc    960

agcatccttc accacgtggc aggagtctgc cacagagagg tgttgattgc ctttcctcac   1020

atttccagga actgagtatc taccaagatc aggaacaaag gatcttaaag ttcctggaag   1080

agcttgggga agggaaggcc accacagcac atgatctgtc tgggaaactt gggactccga   1140

agaaagaaat caatcgagtt ttatactccc tggcaaagaa gggcaagcta cagaaagagg   1200

caggaacacc ccctttgtgg aaaatcgcgg tctccactca ggcttggaac cagcacagcg   1260

gagtggtaag accagacggt catagccaag gagccccaaa ctcagacccg agtttggaac   1320

cggaagacag aaactccaca tctgtctcag aagatcttct tgagcctttt attgcagtct   1380

cagctcaggc ttggaaccag cacagcggag tggtaagacc agacagtcat agccaaggat   1440

ccccaaactc agacccaggt ttggaacctg aagacagcaa ctccacatct gccttggaag   1500

atcctcttga gtttttagac atggccgaga tcaaggagaa aatctgcgac tatctcttca   1560

atgtgtctga ctcctctgcc ctgaatttgg ctaaaaatat tggccttacc aaggcccgag   1620

atataaatgc tgtgctaatt gacatggaaa ggcaggggga tgtctataga caagggacaa   1680

cccctcccat atggcatttg acagacaaga agcgagagag gatgcaaatc aagagaaata   1740

cgaacagtgt tcctgaaacc gctccagctg caatccctga gaccaaaaga aacgcagagt   1800

tcctcacctg taatataccc acatcaaatg cctcaaataa catggtaacc acagaaaaag   1860

tggagaatgg gcaggaacct gtcataaagt tagaaaacag gcaagaggcc agaccagaac   1920

cagcaagact gaaaccacct gttcattaca atggcccctc aaaagcaggg tatgttgact   1980

ttgaaaatgg ccagtgggcc acagatgaca tcccagatga cttgaatagt atccgcgcag   2040

caccaggtga gtttcgagcc atcatggaga tgccctcctt ctacagtcat ggcttgccac   2100

ggtgttcacc ctacaagaaa ctgacagagt gccagctgaa gaaccccatc agcgggctgt   2160

tagaatatgc ccagttcgct agtcaaacct gtgagttcaa catgatagag cagagtggac   2220

caccccatga acctcgattt aaattccagg ttgtcatcaa tggccgagag tttcccccag   2280

ctgaagctgg aagcaagaaa gtggccaagc aggatgcagc tatgaaagcc atgacaattc   2340

tgctagagga agccaaagcc aaggacagtg gaaaatcaga agaatcatcc cactattcca   2400

cagagaaaga atcagagaag actgcagagt cccagacccc caccccttca gccacatcct   2460

tcttttctgg gaagagcccc gtcaccacac tgcttgagtg tatgcacaaa ttggggaact   2520

cctgcgaatt ccgtctcctg tccaaagaag gccctgccca tgaacccaag ttccaatact   2580

gtgttgcagt gggagcccaa actttcccca gtgtgagtgc tcccagcaag aaagtggcaa   2640

agcagatggc cgcagaggaa gccatgaagg ccctgcatgg ggaggcgacc aactccatgg   2700

cttctgataa ccagcctgaa ggtatgatct cagagtcact tgataacttg gaatccatga   2760

tgcccaacaa ggtcaggaag attggcgagc tcgtgagata cctgaacacc aaccctgtgg   2820

gtggcctttt ggagtacgcc cgctcccatg gctttgctgc tgaattcaag ttggtcgacc   2880

agtccggacc tcctcacgag cccaagttcg tttaccaagc aaaagttggg ggtcgctggt   2940

tcccagccgt ctgcgcacac agcaagaagc aaggcaagca ggaagcagca gatgcggctc   3000

tccgtgtctt gattggggag aacgagaagg cagaacgcat gggtttcaca gaggtaaccc   3060

cagtgacagg ggccagtctc agaagaacta tgctcctcct ctcaaggtcc ccagaagcac   3120

agccaaagac actccctctc actggcagca ccttccatga ccagatagcc atgctgagcc   3180

accggtgctt caacactctg actaacagct tccagccctc cttgctcggc cgcaagattc   3240

tggccgccat cattatgaaa aaagactctg aggacatggg tgtcgtcgtc agcttgggaa   3300

cagggaatcg ctgtgtgaaa ggagattctc tcagcctaaa aggagaaact gtcaatgact   3360

gccatgcaga aataatctcc cggagaggct tcatcaggtt tctctacagt gagttaatga   3420

aatacaactc ccagactgcg aaggatagta tatttgaacc tgctaaggga ggagaaaagc   3480

tccaaataaa aaagactgtg tcattccatc tgtatatcag cactgctccg tgtggagatg   3540

gcgccctctt tgacaagtcc tgcagcgacc gtgctatgga aagcacagaa tcccgccact   3600

accctgtctt cgagaatccc aaacaaggaa agctccgcac caaggtggag aacggagaag   3660

gcacaatccc tgtggaatcc agtgacattg tgcctacgtg ggatggcatt cggctcgggg   3720

agagactccg taccatgtcc tgtagtgaca aaatcctacg ctggaacgtg ctgggcctgc   3780

aaggggcact gttgacccac ttcctgcagc ccatttatct caaatctgtc acattgggtt   3840

accttttcag ccaagggcat ctgacccgtg ctatttgctg tcgtgtgaca agagatggga   3900

gtgcatttga ggatggacta cgacatccct ttattgtcaa ccaccccaag gttggcagag   3960

tcagcatata tgattccaaa aggcaatccg ggaagactaa ggagacaagc gtcaactggt   4020

gtctggctga tggctatgac ctggagatcc tggacggtac cagaggcact gtggatgggc   4080

cacggaatga attgtcccgg gtctccaaaa agaacatttt tcttctattt aagaagctct   4140

gctccttccg ttaccgcagg gatctactga gactctccta tggtgaggcc aagaaagctg   4200

cccgtgacta cgagacggcc aagaactact tcaaaaaagg cctgaaggat atgggctatg   4260

ggaactggat tagcaaaccc caggaggaaa agaactttta tctctgccca gtatagtatg   4320

ctccagtgac agatggatta gggtgtgtca tactagggtg tgagagaggt aggtcgtagc   4380

attcctcatc acatggtcag gggatttttt tttctccttt ttttttcttt ttaagccata   4440

attggtgata ctgaaaactt tgggttccca tttatcctgc tttctttggg attgctaggc   4500

aaggtctggc caggcccccc ttttttcccc caagtgaaga ggcagaaacc taagaagtta   4560

tcttttcttt ctacccaaag catacatagt cactgagcac ctgcggtcca tttcctctta   4620

aaagttttgt tttgatttgt ttccatttcc tttccctttg tgtttgctac actgacctct   4680

tgcggtcttg attaggtttc agtcaactct ggatcatgtc agggactgat aatttcattt   4740

gtggattacg cagacccctc tacttcccct ctttcccttc tgagattctt tccttgtgat   4800

ctgaatgtct ccttttcccc ctcagagggc aaagaggtga acataaagga tttggtgaaa   4860

catttgtaag ggtaggagtt gaaaactgca gttcccagtg ccacggaagt gtgattggag   4920

cctgcagata atgcccagcc atcctcccat cctgcacttt agccagctgc agggcgggca   4980

aggcaaggaa agctgcttcc ctggaagtgt atcactttct ccggcagctg ggaagtctag   5040

aaccagccag actgggttaa gggagctgct caagcaatag cagaggtttc acccggcagg   5100

atgacacaga ccacttccca gggagcacgg gcatgccttg gaatattgcc aagcttccag   5160

ctgcctcttc tcctaaagca ttcctaggaa tattttcccc gccaatgctg ggcgtacacc   5220

ctagccaacg ggacaaatcc tagagggtat aaaatcatct ctgctcagat aatcatgact   5280

tagcaagaat aagggcaaaa aatcctgttg gcttaacgtc actgttccac ccggtgtaat   5340

atctctcatg acagtgacac caagggaagt tgactaagtc acatgtaaat taggagtgtt   5400

ttaaagaatg ccatagatgt tgattcttaa ctgctacaga taacctgtaa ttgagcagat   5460

ttaaaattca ggcatacttt tccatttatc caagtgcttt catttttcca gatggcttca   5520

gaagtaggct cgtgggcagg gcgcagacct gatctttata gggttgacat agaaagcagt   5580

agttgtgggt gaaagggcag gttgtcttca aactctgtga ggtagaatcc tttgtctata   5640

cctccatgaa cattgactcg tgtgttcaga gcctttggcc tctctgtgga gtctggctct   5700

ctggctcctg tgcattcttt gaatagtcac tcgtaaaaac tgtcagtgct tgaaactgtt   5760

tcctttactc atgttgaagg gactttgttg gcttttagag tgttggtcat gactccaaga   5820

gcagagcagg gaagagccca agcatagact tggtgccgtg gtgatggctg cagtccagtt   5880

ttgtgatgct gcttttacgt gtccctcgat aacagtcagc tagacacact caggaggact   5940

actgaggctc tgcgaccttc aggagctgag cctgcctctc tcctttagat gacagacctt   6000

catctgggaa cgtgctgagc cagcaccctc agatgatttc cctccaaact gctgactagg   6060

tcatcctctg tctggtagag acattcacat ctttgctttt attctatgct ctctgtactt   6120

ttgaccaaaa attgaccaaa gtaagaaaat gcaagttcta aaaatagact aaggatgcct   6180

ttgcagaaca ccaaagcatc ccaaggaact ggtagggaag tggcgcctgt ctcctggagt   6240

ggaagaggcc tgctccctgg ctctgggtct gctgggggca cagtaaatca gtcttggcac   6300

ccacatccag ggcagagagg tctgtggttc tcagcatcag aaggcagcgc agcccctctc   6360

ctcttcaggc tacagggttg tcacctgctg agtcctcagg ttgtttggcc tctctggtcc   6420

atcttgggca ttaggttctc cagcagagct ctggccagct gcctcttctt taactgggaa   6480

cacaggctct cacaagatca gaacccccac tcacccccaa gatcttatct agcaagcctg   6540

tagtattcag tttctgttgt aggaagagag cgaggcatcc ctgaattcca cgcatctgct   6600

ggaaacgagc cgtgtcagat cgcacatccc tgcgccccca tgcccctctg agtcacacag   6660

gacagaggag gcagagcttc tgcccactgt tatcttcact ttctttgtcc agtcttttgt   6720

ttttaataag cagtgaccct ccctactctt ctttttaatg atttttgtag ttgatttgtc   6780

tgaactgtgg ctactgtgca ttccttgaat aatcacttgt aaaaattgtc agtgcttgaa   6840

gctgtttcct ttactcacat tgaagggact tcgttggttt tttggagtct tggttgtgac   6900

tccaagagca gagtgaggaa gacccccaag catagactcg ggtactgtga tgatggctgc   6960

agtccagttt tatgattctg cttttatgtg tcccttgata acagtgactt aacaatatac   7020

attcctcata aataaaaaaa aaacaagaat ctgaattctt agaaa                   7065


<210>  1245
<211>  1226
<212>  PRT
<213>  Homo sapiens

<400>  1245


Met Asn Pro Arg Gln Gly Tyr Ser Leu Ser Gly Tyr Tyr Thr His Pro 
1               5                   10                  15      


Phe Gln Gly Tyr Glu His Arg Gln Leu Arg Tyr Gln Gln Pro Gly Pro 
            20                  25                  30          


Gly Ser Ser Pro Ser Ser Phe Leu Leu Lys Gln Ile Glu Phe Leu Lys 
        35                  40                  45              


Gly Gln Leu Pro Glu Ala Pro Val Ile Gly Lys Gln Thr Pro Ser Leu 
    50                  55                  60                  


Pro Pro Ser Leu Pro Gly Leu Arg Pro Arg Phe Pro Val Leu Leu Ala 
65                  70                  75                  80  


Ser Ser Thr Arg Gly Arg Gln Val Asp Ile Arg Gly Val Pro Arg Gly 
                85                  90                  95      


Val His Leu Arg Ser Gln Gly Leu Gln Arg Gly Phe Gln His Pro Ser 
            100                 105                 110         


Pro Arg Gly Arg Ser Leu Pro Gln Arg Gly Val Asp Cys Leu Ser Ser 
        115                 120                 125             


His Phe Gln Glu Leu Ser Ile Tyr Gln Asp Gln Glu Gln Arg Ile Leu 
    130                 135                 140                 


Lys Phe Leu Glu Glu Leu Gly Glu Gly Lys Ala Thr Thr Ala His Asp 
145                 150                 155                 160 


Leu Ser Gly Lys Leu Gly Thr Pro Lys Lys Glu Ile Asn Arg Val Leu 
                165                 170                 175     


Tyr Ser Leu Ala Lys Lys Gly Lys Leu Gln Lys Glu Ala Gly Thr Pro 
            180                 185                 190         


Pro Leu Trp Lys Ile Ala Val Ser Thr Gln Ala Trp Asn Gln His Ser 
        195                 200                 205             


Gly Val Val Arg Pro Asp Gly His Ser Gln Gly Ala Pro Asn Ser Asp 
    210                 215                 220                 


Pro Ser Leu Glu Pro Glu Asp Arg Asn Ser Thr Ser Val Ser Glu Asp 
225                 230                 235                 240 


Leu Leu Glu Pro Phe Ile Ala Val Ser Ala Gln Ala Trp Asn Gln His 
                245                 250                 255     


Ser Gly Val Val Arg Pro Asp Ser His Ser Gln Gly Ser Pro Asn Ser 
            260                 265                 270         


Asp Pro Gly Leu Glu Pro Glu Asp Ser Asn Ser Thr Ser Ala Leu Glu 
        275                 280                 285             


Asp Pro Leu Glu Phe Leu Asp Met Ala Glu Ile Lys Glu Lys Ile Cys 
    290                 295                 300                 


Asp Tyr Leu Phe Asn Val Ser Asp Ser Ser Ala Leu Asn Leu Ala Lys 
305                 310                 315                 320 


Asn Ile Gly Leu Thr Lys Ala Arg Asp Ile Asn Ala Val Leu Ile Asp 
                325                 330                 335     


Met Glu Arg Gln Gly Asp Val Tyr Arg Gln Gly Thr Thr Pro Pro Ile 
            340                 345                 350         


Trp His Leu Thr Asp Lys Lys Arg Glu Arg Met Gln Ile Lys Arg Asn 
        355                 360                 365             


Thr Asn Ser Val Pro Glu Thr Ala Pro Ala Ala Ile Pro Glu Thr Lys 
    370                 375                 380                 


Arg Asn Ala Glu Phe Leu Thr Cys Asn Ile Pro Thr Ser Asn Ala Ser 
385                 390                 395                 400 


Asn Asn Met Val Thr Thr Glu Lys Val Glu Asn Gly Gln Glu Pro Val 
                405                 410                 415     


Ile Lys Leu Glu Asn Arg Gln Glu Ala Arg Pro Glu Pro Ala Arg Leu 
            420                 425                 430         


Lys Pro Pro Val His Tyr Asn Gly Pro Ser Lys Ala Gly Tyr Val Asp 
        435                 440                 445             


Phe Glu Asn Gly Gln Trp Ala Thr Asp Asp Ile Pro Asp Asp Leu Asn 
    450                 455                 460                 


Ser Ile Arg Ala Ala Pro Gly Glu Phe Arg Ala Ile Met Glu Met Pro 
465                 470                 475                 480 


Ser Phe Tyr Ser His Gly Leu Pro Arg Cys Ser Pro Tyr Lys Lys Leu 
                485                 490                 495     


Thr Glu Cys Gln Leu Lys Asn Pro Ile Ser Gly Leu Leu Glu Tyr Ala 
            500                 505                 510         


Gln Phe Ala Ser Gln Thr Cys Glu Phe Asn Met Ile Glu Gln Ser Gly 
        515                 520                 525             


Pro Pro His Glu Pro Arg Phe Lys Phe Gln Val Val Ile Asn Gly Arg 
    530                 535                 540                 


Glu Phe Pro Pro Ala Glu Ala Gly Ser Lys Lys Val Ala Lys Gln Asp 
545                 550                 555                 560 


Ala Ala Met Lys Ala Met Thr Ile Leu Leu Glu Glu Ala Lys Ala Lys 
                565                 570                 575     


Asp Ser Gly Lys Ser Glu Glu Ser Ser His Tyr Ser Thr Glu Lys Glu 
            580                 585                 590         


Ser Glu Lys Thr Ala Glu Ser Gln Thr Pro Thr Pro Ser Ala Thr Ser 
        595                 600                 605             


Phe Phe Ser Gly Lys Ser Pro Val Thr Thr Leu Leu Glu Cys Met His 
    610                 615                 620                 


Lys Leu Gly Asn Ser Cys Glu Phe Arg Leu Leu Ser Lys Glu Gly Pro 
625                 630                 635                 640 


Ala His Glu Pro Lys Phe Gln Tyr Cys Val Ala Val Gly Ala Gln Thr 
                645                 650                 655     


Phe Pro Ser Val Ser Ala Pro Ser Lys Lys Val Ala Lys Gln Met Ala 
            660                 665                 670         


Ala Glu Glu Ala Met Lys Ala Leu His Gly Glu Ala Thr Asn Ser Met 
        675                 680                 685             


Ala Ser Asp Asn Gln Pro Glu Gly Met Ile Ser Glu Ser Leu Asp Asn 
    690                 695                 700                 


Leu Glu Ser Met Met Pro Asn Lys Val Arg Lys Ile Gly Glu Leu Val 
705                 710                 715                 720 


Arg Tyr Leu Asn Thr Asn Pro Val Gly Gly Leu Leu Glu Tyr Ala Arg 
                725                 730                 735     


Ser His Gly Phe Ala Ala Glu Phe Lys Leu Val Asp Gln Ser Gly Pro 
            740                 745                 750         


Pro His Glu Pro Lys Phe Val Tyr Gln Ala Lys Val Gly Gly Arg Trp 
        755                 760                 765             


Phe Pro Ala Val Cys Ala His Ser Lys Lys Gln Gly Lys Gln Glu Ala 
    770                 775                 780                 


Ala Asp Ala Ala Leu Arg Val Leu Ile Gly Glu Asn Glu Lys Ala Glu 
785                 790                 795                 800 


Arg Met Gly Phe Thr Glu Val Thr Pro Val Thr Gly Ala Ser Leu Arg 
                805                 810                 815     


Arg Thr Met Leu Leu Leu Ser Arg Ser Pro Glu Ala Gln Pro Lys Thr 
            820                 825                 830         


Leu Pro Leu Thr Gly Ser Thr Phe His Asp Gln Ile Ala Met Leu Ser 
        835                 840                 845             


His Arg Cys Phe Asn Thr Leu Thr Asn Ser Phe Gln Pro Ser Leu Leu 
    850                 855                 860                 


Gly Arg Lys Ile Leu Ala Ala Ile Ile Met Lys Lys Asp Ser Glu Asp 
865                 870                 875                 880 


Met Gly Val Val Val Ser Leu Gly Thr Gly Asn Arg Cys Val Lys Gly 
                885                 890                 895     


Asp Ser Leu Ser Leu Lys Gly Glu Thr Val Asn Asp Cys His Ala Glu 
            900                 905                 910         


Ile Ile Ser Arg Arg Gly Phe Ile Arg Phe Leu Tyr Ser Glu Leu Met 
        915                 920                 925             


Lys Tyr Asn Ser Gln Thr Ala Lys Asp Ser Ile Phe Glu Pro Ala Lys 
    930                 935                 940                 


Gly Gly Glu Lys Leu Gln Ile Lys Lys Thr Val Ser Phe His Leu Tyr 
945                 950                 955                 960 


Ile Ser Thr Ala Pro Cys Gly Asp Gly Ala Leu Phe Asp Lys Ser Cys 
                965                 970                 975     


Ser Asp Arg Ala Met Glu Ser Thr Glu Ser Arg His Tyr Pro Val Phe 
            980                 985                 990         


Glu Asn Pro Lys Gln Gly Lys Leu  Arg Thr Lys Val Glu  Asn Gly Glu 
        995                 1000                 1005             


Gly Thr  Ile Pro Val Glu Ser  Ser Asp Ile Val Pro  Thr Trp Asp 
    1010                 1015                 1020             


Gly Ile  Arg Leu Gly Glu Arg  Leu Arg Thr Met Ser  Cys Ser Asp 
    1025                 1030                 1035             


Lys Ile  Leu Arg Trp Asn Val  Leu Gly Leu Gln Gly  Ala Leu Leu 
    1040                 1045                 1050             


Thr His  Phe Leu Gln Pro Ile  Tyr Leu Lys Ser Val  Thr Leu Gly 
    1055                 1060                 1065             


Tyr Leu  Phe Ser Gln Gly His  Leu Thr Arg Ala Ile  Cys Cys Arg 
    1070                 1075                 1080             


Val Thr  Arg Asp Gly Ser Ala  Phe Glu Asp Gly Leu  Arg His Pro 
    1085                 1090                 1095             


Phe Ile  Val Asn His Pro Lys  Val Gly Arg Val Ser  Ile Tyr Asp 
    1100                 1105                 1110             


Ser Lys  Arg Gln Ser Gly Lys  Thr Lys Glu Thr Ser  Val Asn Trp 
    1115                 1120                 1125             


Cys Leu  Ala Asp Gly Tyr Asp  Leu Glu Ile Leu Asp  Gly Thr Arg 
    1130                 1135                 1140             


Gly Thr  Val Asp Gly Pro Arg  Asn Glu Leu Ser Arg  Val Ser Lys 
    1145                 1150                 1155             


Lys Asn  Ile Phe Leu Leu Phe  Lys Lys Leu Cys Ser  Phe Arg Tyr 
    1160                 1165                 1170             


Arg Arg  Asp Leu Leu Arg Leu  Ser Tyr Gly Glu Ala  Lys Lys Ala 
    1175                 1180                 1185             


Ala Arg  Asp Tyr Glu Thr Ala  Lys Asn Tyr Phe Lys  Lys Gly Leu 
    1190                 1195                 1200             


Lys Asp  Met Gly Tyr Gly Asn  Trp Ile Ser Lys Pro  Gln Glu Glu 
    1205                 1210                 1215             


Lys Asn  Phe Tyr Leu Cys Pro  Val 
    1220                 1225     

<210>  1246
<211>  6541
<212>  DNA
<213>  Homo sapiens

<400>  1246
gaccagacca ttgattcccg actgaaggta gagaaggcta cgtggtgggg gagggtgggg     60

ggagggtcgc ggccgcactg gcagtctccg ggtgtccggc cgtgtcccga ggaagtgcaa    120

gacccggggt attccctcag cggatactac acccatccat ttcaaggcta tgagcacaga    180

cagctcaggt accagcagcc tgggccagga tcttccccca gtagtttcct gcttaagcaa    240

atagaatttc tcaaggggca gctcccagaa gcaccggtga ttggaaagca gacaccgtca    300

ctgccacctt ccctcccagg actccggcca aggtttccag tactacttgc ctccagtacc    360

agaggcaggc aagtggacat caggggtgtc cccaggggcg tgcatctcag aagtcagggg    420

ctccagagag ggttccagca tccttcacca cgtggcagga gtctgccaca gagaggtgtt    480

gattgccttt cctcacattt ccaggaactg agtatctacc aagatcagga acaaaggatc    540

ttaaagttcc tggaagagct tggggaaggg aaggccacca cagcacatga tctgtctggg    600

aaacttggga ctccgaagaa agaaatcaat cgagttttat actccctggc aaagaagggc    660

aagctacaga aagaggcagg aacaccccct ttgtggaaaa tcgcggtctc cactcaggct    720

tggaaccagc acagcggagt ggtaagacca gacggtcata gccaaggagc cccaaactca    780

gacccgagtt tggaaccgga agacagaaac tccacatctg tctcagaaga tcttcttgag    840

ccttttattg cagtctcagc tcaggcttgg aaccagcaca gcggagtggt aagaccagac    900

agtcatagcc aaggatcccc aaactcagac ccaggtttgg aacctgaaga cagcaactcc    960

acatctgcct tggaagatcc tcttgagttt ttagacatgg ccgagatcaa ggagaaaatc   1020

tgcgactatc tcttcaatgt gtctgactcc tctgccctga atttggctaa aaatattggc   1080

cttaccaagg cccgagatat aaatgctgtg ctaattgaca tggaaaggca gggggatgtc   1140

tatagacaag ggacaacccc tcccatatgg catttgacag acaagaagcg agagaggatg   1200

caaatcaaga gaaatacgaa cagtgttcct gaaaccgctc cagctgcaat ccctgagacc   1260

aaaagaaacg cagagttcct cacctgtaat atacccacat caaatgcctc aaataacatg   1320

gtaaccacag aaaaagtgga gaatgggcag gaacctgtca taaagttaga aaacaggcaa   1380

gaggccagac cagaaccagc aagactgaaa ccacctgttc attacaatgg cccctcaaaa   1440

gcagggtatg ttgactttga aaatggccag tgggccacag atgacatccc agatgacttg   1500

aatagtatcc gcgcagcacc aggtgagttt cgagccatca tggagatgcc ctccttctac   1560

agtcatggct tgccacggtg ttcaccctac aagaaactga cagagtgcca gctgaagaac   1620

cccatcagcg ggctgttaga atatgcccag ttcgctagtc aaacctgtga gttcaacatg   1680

atagagcaga gtggaccacc ccatgaacct cgatttaaat tccaggttgt catcaatggc   1740

cgagagtttc ccccagctga agctggaagc aagaaagtgg ccaagcagga tgcagctatg   1800

aaagccatga caattctgct agaggaagcc aaagccaagg acagtggaaa atcagaagaa   1860

tcatcccact attccacaga gaaagaatca gagaagactg cagagtccca gacccccacc   1920

ccttcagcca catccttctt ttctgggaag agccccgtca ccacactgct tgagtgtatg   1980

cacaaattgg ggaactcctg cgaattccgt ctcctgtcca aagaaggccc tgcccatgaa   2040

cccaagttcc aatactgtgt tgcagtggga gcccaaactt tccccagtgt gagtgctccc   2100

agcaagaaag tggcaaagca gatggccgca gaggaagcca tgaaggccct gcatggggag   2160

gcgaccaact ccatggcttc tgataaccag cctgaaggta tgatctcaga gtcacttgat   2220

aacttggaat ccatgatgcc caacaaggtc aggaagattg gcgagctcgt gagatacctg   2280

aacaccaacc ctgtgggtgg ccttttggag tacgcccgct cccatggctt tgctgctgaa   2340

ttcaagttgg tcgaccagtc cggacctcct cacgagccca agttcgttta ccaagcaaaa   2400

gttgggggtc gctggttccc agccgtctgc gcacacagca agaagcaagg caagcaggaa   2460

gcagcagatg cggctctccg tgtcttgatt ggggagaacg agaaggcaga acgcatgggt   2520

ttcacagagg taaccccagt gacaggggcc agtctcagaa gaactatgct cctcctctca   2580

aggtccccag aagcacagcc aaagacactc cctctcactg gcagcacctt ccatgaccag   2640

atagccatgc tgagccaccg gtgcttcaac actctgacta acagcttcca gccctccttg   2700

ctcggccgca agattctggc cgccatcatt atgaaaaaag actctgagga catgggtgtc   2760

gtcgtcagct tgggaacagg gaatcgctgt gtgaaaggag attctctcag cctaaaagga   2820

gaaactgtca atgactgcca tgcagaaata atctcccgga gaggcttcat caggtttctc   2880

tacagtgagt taatgaaata caactcccag actgcgaagg atagtatatt tgaacctgct   2940

aagggaggag aaaagctcca aataaaaaag actgtgtcat tccatctgta tatcagcact   3000

gctccgtgtg gagatggcgc cctctttgac aagtcctgca gcgaccgtgc tatggaaagc   3060

acagaatccc gccactaccc tgtcttcgag aatcccaaac aaggaaagct ccgcaccaag   3120

gtggagaacg gagaaggcac aatccctgtg gaatccagtg acattgtgcc tacgtgggat   3180

ggcattcggc tcggggagag actccgtacc atgtcctgta gtgacaaaat cctacgctgg   3240

aacgtgctgg gcctgcaagg ggcactgttg acccacttcc tgcagcccat ttatctcaaa   3300

tctgtcacat tgggttacct tttcagccaa gggcatctga cccgtgctat ttgctgtcgt   3360

gtgacaagag atgggagtgc atttgaggat ggactacgac atccctttat tgtcaaccac   3420

cccaaggttg gcagagtcag catatatgat tccaaaaggc aatccgggaa gactaaggag   3480

acaagcgtca actggtgtct ggctgatggc tatgacctgg agatcctgga cggtaccaga   3540

ggcactgtgg atgggccacg gaatgaattg tcccgggtct ccaaaaagaa catttttctt   3600

ctatttaaga agctctgctc cttccgttac cgcagggatc tactgagact ctcctatggt   3660

gaggccaaga aagctgcccg tgactacgag acggccaaga actacttcaa aaaaggcctg   3720

aaggatatgg gctatgggaa ctggattagc aaaccccagg aggaaaagaa cttttatctc   3780

tgcccagtat agtatgctcc agtgacagat ggattagggt gtgtcatact agggtgtgag   3840

agaggtaggt cgtagcattc ctcatcacat ggtcagggga tttttttttc tccttttttt   3900

ttctttttaa gccataattg gtgatactga aaactttggg ttcccattta tcctgctttc   3960

tttgggattg ctaggcaagg tctggccagg cccccctttt ttcccccaag tgaagaggca   4020

gaaacctaag aagttatctt ttctttctac ccaaagcata catagtcact gagcacctgc   4080

ggtccatttc ctcttaaaag ttttgttttg atttgtttcc atttcctttc cctttgtgtt   4140

tgctacactg acctcttgcg gtcttgatta ggtttcagtc aactctggat catgtcaggg   4200

actgataatt tcatttgtgg attacgcaga cccctctact tcccctcttt cccttctgag   4260

attctttcct tgtgatctga atgtctcctt ttccccctca gagggcaaag aggtgaacat   4320

aaaggatttg gtgaaacatt tgtaagggta ggagttgaaa actgcagttc ccagtgccac   4380

ggaagtgtga ttggagcctg cagataatgc ccagccatcc tcccatcctg cactttagcc   4440

agctgcaggg cgggcaaggc aaggaaagct gcttccctgg aagtgtatca ctttctccgg   4500

cagctgggaa gtctagaacc agccagactg ggttaaggga gctgctcaag caatagcaga   4560

ggtttcaccc ggcaggatga cacagaccac ttcccaggga gcacgggcat gccttggaat   4620

attgccaagc ttccagctgc ctcttctcct aaagcattcc taggaatatt ttccccgcca   4680

atgctgggcg tacaccctag ccaacgggac aaatcctaga gggtataaaa tcatctctgc   4740

tcagataatc atgacttagc aagaataagg gcaaaaaatc ctgttggctt aacgtcactg   4800

ttccacccgg tgtaatatct ctcatgacag tgacaccaag ggaagttgac taagtcacat   4860

gtaaattagg agtgttttaa agaatgccat agatgttgat tcttaactgc tacagataac   4920

ctgtaattga gcagatttaa aattcaggca tacttttcca tttatccaag tgctttcatt   4980

tttccagatg gcttcagaag taggctcgtg ggcagggcgc agacctgatc tttatagggt   5040

tgacatagaa agcagtagtt gtgggtgaaa gggcaggttg tcttcaaact ctgtgaggta   5100

gaatcctttg tctatacctc catgaacatt gactcgtgtg ttcagagcct ttggcctctc   5160

tgtggagtct ggctctctgg ctcctgtgca ttctttgaat agtcactcgt aaaaactgtc   5220

agtgcttgaa actgtttcct ttactcatgt tgaagggact ttgttggctt ttagagtgtt   5280

ggtcatgact ccaagagcag agcagggaag agcccaagca tagacttggt gccgtggtga   5340

tggctgcagt ccagttttgt gatgctgctt ttacgtgtcc ctcgataaca gtcagctaga   5400

cacactcagg aggactactg aggctctgcg accttcagga gctgagcctg cctctctcct   5460

ttagatgaca gaccttcatc tgggaacgtg ctgagccagc accctcagat gatttccctc   5520

caaactgctg actaggtcat cctctgtctg gtagagacat tcacatcttt gcttttattc   5580

tatgctctct gtacttttga ccaaaaattg accaaagtaa gaaaatgcaa gttctaaaaa   5640

tagactaagg atgcctttgc agaacaccaa agcatcccaa ggaactggta gggaagtggc   5700

gcctgtctcc tggagtggaa gaggcctgct ccctggctct gggtctgctg ggggcacagt   5760

aaatcagtct tggcacccac atccagggca gagaggtctg tggttctcag catcagaagg   5820

cagcgcagcc cctctcctct tcaggctaca gggttgtcac ctgctgagtc ctcaggttgt   5880

ttggcctctc tggtccatct tgggcattag gttctccagc agagctctgg ccagctgcct   5940

cttctttaac tgggaacaca ggctctcaca agatcagaac ccccactcac ccccaagatc   6000

ttatctagca agcctgtagt attcagtttc tgttgtagga agagagcgag gcatccctga   6060

attccacgca tctgctggaa acgagccgtg tcagatcgca catccctgcg cccccatgcc   6120

cctctgagtc acacaggaca gaggaggcag agcttctgcc cactgttatc ttcactttct   6180

ttgtccagtc ttttgttttt aataagcagt gaccctccct actcttcttt ttaatgattt   6240

ttgtagttga tttgtctgaa ctgtggctac tgtgcattcc ttgaataatc acttgtaaaa   6300

attgtcagtg cttgaagctg tttcctttac tcacattgaa gggacttcgt tggttttttg   6360

gagtcttggt tgtgactcca agagcagagt gaggaagacc cccaagcata gactcgggta   6420

ctgtgatgat ggctgcagtc cagttttatg attctgcttt tatgtgtccc ttgataacag   6480

tgacttaaca atatacattc ctcataaata aaaaaaaaac aagaatctga attcttagaa   6540

a                                                                   6541


<210>  1247
<211>  931
<212>  PRT
<213>  Homo sapiens

<400>  1247


Met Ala Glu Ile Lys Glu Lys Ile Cys Asp Tyr Leu Phe Asn Val Ser 
1               5                   10                  15      


Asp Ser Ser Ala Leu Asn Leu Ala Lys Asn Ile Gly Leu Thr Lys Ala 
            20                  25                  30          


Arg Asp Ile Asn Ala Val Leu Ile Asp Met Glu Arg Gln Gly Asp Val 
        35                  40                  45              


Tyr Arg Gln Gly Thr Thr Pro Pro Ile Trp His Leu Thr Asp Lys Lys 
    50                  55                  60                  


Arg Glu Arg Met Gln Ile Lys Arg Asn Thr Asn Ser Val Pro Glu Thr 
65                  70                  75                  80  


Ala Pro Ala Ala Ile Pro Glu Thr Lys Arg Asn Ala Glu Phe Leu Thr 
                85                  90                  95      


Cys Asn Ile Pro Thr Ser Asn Ala Ser Asn Asn Met Val Thr Thr Glu 
            100                 105                 110         


Lys Val Glu Asn Gly Gln Glu Pro Val Ile Lys Leu Glu Asn Arg Gln 
        115                 120                 125             


Glu Ala Arg Pro Glu Pro Ala Arg Leu Lys Pro Pro Val His Tyr Asn 
    130                 135                 140                 


Gly Pro Ser Lys Ala Gly Tyr Val Asp Phe Glu Asn Gly Gln Trp Ala 
145                 150                 155                 160 


Thr Asp Asp Ile Pro Asp Asp Leu Asn Ser Ile Arg Ala Ala Pro Gly 
                165                 170                 175     


Glu Phe Arg Ala Ile Met Glu Met Pro Ser Phe Tyr Ser His Gly Leu 
            180                 185                 190         


Pro Arg Cys Ser Pro Tyr Lys Lys Leu Thr Glu Cys Gln Leu Lys Asn 
        195                 200                 205             


Pro Ile Ser Gly Leu Leu Glu Tyr Ala Gln Phe Ala Ser Gln Thr Cys 
    210                 215                 220                 


Glu Phe Asn Met Ile Glu Gln Ser Gly Pro Pro His Glu Pro Arg Phe 
225                 230                 235                 240 


Lys Phe Gln Val Val Ile Asn Gly Arg Glu Phe Pro Pro Ala Glu Ala 
                245                 250                 255     


Gly Ser Lys Lys Val Ala Lys Gln Asp Ala Ala Met Lys Ala Met Thr 
            260                 265                 270         


Ile Leu Leu Glu Glu Ala Lys Ala Lys Asp Ser Gly Lys Ser Glu Glu 
        275                 280                 285             


Ser Ser His Tyr Ser Thr Glu Lys Glu Ser Glu Lys Thr Ala Glu Ser 
    290                 295                 300                 


Gln Thr Pro Thr Pro Ser Ala Thr Ser Phe Phe Ser Gly Lys Ser Pro 
305                 310                 315                 320 


Val Thr Thr Leu Leu Glu Cys Met His Lys Leu Gly Asn Ser Cys Glu 
                325                 330                 335     


Phe Arg Leu Leu Ser Lys Glu Gly Pro Ala His Glu Pro Lys Phe Gln 
            340                 345                 350         


Tyr Cys Val Ala Val Gly Ala Gln Thr Phe Pro Ser Val Ser Ala Pro 
        355                 360                 365             


Ser Lys Lys Val Ala Lys Gln Met Ala Ala Glu Glu Ala Met Lys Ala 
    370                 375                 380                 


Leu His Gly Glu Ala Thr Asn Ser Met Ala Ser Asp Asn Gln Pro Glu 
385                 390                 395                 400 


Gly Met Ile Ser Glu Ser Leu Asp Asn Leu Glu Ser Met Met Pro Asn 
                405                 410                 415     


Lys Val Arg Lys Ile Gly Glu Leu Val Arg Tyr Leu Asn Thr Asn Pro 
            420                 425                 430         


Val Gly Gly Leu Leu Glu Tyr Ala Arg Ser His Gly Phe Ala Ala Glu 
        435                 440                 445             


Phe Lys Leu Val Asp Gln Ser Gly Pro Pro His Glu Pro Lys Phe Val 
    450                 455                 460                 


Tyr Gln Ala Lys Val Gly Gly Arg Trp Phe Pro Ala Val Cys Ala His 
465                 470                 475                 480 


Ser Lys Lys Gln Gly Lys Gln Glu Ala Ala Asp Ala Ala Leu Arg Val 
                485                 490                 495     


Leu Ile Gly Glu Asn Glu Lys Ala Glu Arg Met Gly Phe Thr Glu Val 
            500                 505                 510         


Thr Pro Val Thr Gly Ala Ser Leu Arg Arg Thr Met Leu Leu Leu Ser 
        515                 520                 525             


Arg Ser Pro Glu Ala Gln Pro Lys Thr Leu Pro Leu Thr Gly Ser Thr 
    530                 535                 540                 


Phe His Asp Gln Ile Ala Met Leu Ser His Arg Cys Phe Asn Thr Leu 
545                 550                 555                 560 


Thr Asn Ser Phe Gln Pro Ser Leu Leu Gly Arg Lys Ile Leu Ala Ala 
                565                 570                 575     


Ile Ile Met Lys Lys Asp Ser Glu Asp Met Gly Val Val Val Ser Leu 
            580                 585                 590         


Gly Thr Gly Asn Arg Cys Val Lys Gly Asp Ser Leu Ser Leu Lys Gly 
        595                 600                 605             


Glu Thr Val Asn Asp Cys His Ala Glu Ile Ile Ser Arg Arg Gly Phe 
    610                 615                 620                 


Ile Arg Phe Leu Tyr Ser Glu Leu Met Lys Tyr Asn Ser Gln Thr Ala 
625                 630                 635                 640 


Lys Asp Ser Ile Phe Glu Pro Ala Lys Gly Gly Glu Lys Leu Gln Ile 
                645                 650                 655     


Lys Lys Thr Val Ser Phe His Leu Tyr Ile Ser Thr Ala Pro Cys Gly 
            660                 665                 670         


Asp Gly Ala Leu Phe Asp Lys Ser Cys Ser Asp Arg Ala Met Glu Ser 
        675                 680                 685             


Thr Glu Ser Arg His Tyr Pro Val Phe Glu Asn Pro Lys Gln Gly Lys 
    690                 695                 700                 


Leu Arg Thr Lys Val Glu Asn Gly Glu Gly Thr Ile Pro Val Glu Ser 
705                 710                 715                 720 


Ser Asp Ile Val Pro Thr Trp Asp Gly Ile Arg Leu Gly Glu Arg Leu 
                725                 730                 735     


Arg Thr Met Ser Cys Ser Asp Lys Ile Leu Arg Trp Asn Val Leu Gly 
            740                 745                 750         


Leu Gln Gly Ala Leu Leu Thr His Phe Leu Gln Pro Ile Tyr Leu Lys 
        755                 760                 765             


Ser Val Thr Leu Gly Tyr Leu Phe Ser Gln Gly His Leu Thr Arg Ala 
    770                 775                 780                 


Ile Cys Cys Arg Val Thr Arg Asp Gly Ser Ala Phe Glu Asp Gly Leu 
785                 790                 795                 800 


Arg His Pro Phe Ile Val Asn His Pro Lys Val Gly Arg Val Ser Ile 
                805                 810                 815     


Tyr Asp Ser Lys Arg Gln Ser Gly Lys Thr Lys Glu Thr Ser Val Asn 
            820                 825                 830         


Trp Cys Leu Ala Asp Gly Tyr Asp Leu Glu Ile Leu Asp Gly Thr Arg 
        835                 840                 845             


Gly Thr Val Asp Gly Pro Arg Asn Glu Leu Ser Arg Val Ser Lys Lys 
    850                 855                 860                 


Asn Ile Phe Leu Leu Phe Lys Lys Leu Cys Ser Phe Arg Tyr Arg Arg 
865                 870                 875                 880 


Asp Leu Leu Arg Leu Ser Tyr Gly Glu Ala Lys Lys Ala Ala Arg Asp 
                885                 890                 895     


Tyr Glu Thr Ala Lys Asn Tyr Phe Lys Lys Gly Leu Lys Asp Met Gly 
            900                 905                 910         


Tyr Gly Asn Trp Ile Ser Lys Pro Gln Glu Glu Lys Asn Phe Tyr Leu 
        915                 920                 925             


Cys Pro Val 
    930     

<210>  1248
<211>  1488
<212>  DNA
<213>  Homo sapiens

<400>  1248
attgctaggc aaggtctggc caggcccccc ttttttcccc caagtgaaga ggcagaaacc     60

taagaagtta tcttttcttt ctacccaaag catacatagt cactgagcac ctgcggtcca    120

tttcctctta aaagttttgt tttgatttgt ttccatttcc tttccctttg tgtttgctac    180

actgacctct tgcggtcttg attaggtttc agtcaactct ggatcatgtc agggactgat    240

aatttcattt gtggattacg cagacccctc tacttcccct ctttcccttc tgagattctt    300

tccttgtgat ctgaatgtct ccttttcccc ctcagagggc aaagaggtga acataaagga    360

tttggtgaaa catttgtaag ggtaggagtt gaaaactgca gttcccagtg ccacggaagt    420

gtgattggag cctgcagata atgcccagcc atcctcccat cctgcacttt agccagctgc    480

agggcgggca aggcaaggaa agctgcttcc ctggaagtgt atcactttct ccggcagctg    540

ggaagtctag aaccagccag actgggttaa gggagctgct caagcaatag cagaggtttc    600

acccggcagg atgacacaga ccacttccca gggagcacgg gcatgccttg gaatattgcc    660

aagcttccag ctgcctcttc tcctaaagca ttcctaggaa tattttcccc gccaatgctg    720

ggcgtacacc ctagccaacg ggacaaatcc tagagggtat aaaatcatct ctgctcagat    780

aatcatgact tagcaagaat aagggcaaaa aatcctgttg gcttaacgtc actgttccac    840

ccggtgtaat atctctcatg acagtgacac caagggaagt tgactaagtc acatgtaaat    900

taggagtgtt ttaaagaatg ccatagatgt tgattcttaa ctgctacaga taacctgtaa    960

ttgagcagat ttaaaattca ggcatacttt tccatttatc caagtgcttt catttttcca   1020

gatggcttca gaagtaggct cgtgggcagg gcgcagacct gatctttata gggttgacat   1080

agaaagcagt agttgtgggt gaaagggcag gttgtcttca aactctgtga ggtagaatcc   1140

tttgtctata cctccatgaa cattgactcg tgtgttcaga gcctttggcc tctctgtgga   1200

gtctggctct ctggctcctg tgcattcttt gaatagtcac tcgtaaaaac tgtcagtgct   1260

tgaaactctg tttcctttac tcacattgaa gggacttcgt tggttttttg gagtcttggt   1320

tgtgactcca agagcagagt gaggaagacc cccaagcata gactcgggta ctgtgatgat   1380

ggctgcagtc cagttttatg attctgcttt tatgtgtccc ttgataacag tgacttaaca   1440

atatacattc ctcataaata aaaaaaaaac aagaatctga attcttag                1488


<210>  1249
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  1249


Met Pro Ser His Pro Pro Ile Leu His Phe Ser Gln Leu Gln Gly Gly 
1               5                   10                  15      


Gln Gly Lys Glu Ser Cys Phe Pro Gly Ser Val Ser Leu Ser Pro Ala 
            20                  25                  30          


Ala Gly Lys Ser Arg Thr Ser Gln Thr Gly Leu Arg Glu Leu Leu Lys 
        35                  40                  45              


Gln 
    

<210>  1250
<211>  953
<212>  DNA
<213>  Homo sapiens

<400>  1250
aatgaattgt cccgggtctc caaaaagaac atttttcttc tatttaagaa gctctgctcc     60

ttccgttacc gcagggatct actgagactc tcctatggtg aggccaagaa agctgcccgt    120

gactacgaga cggccaagaa ctacttcaaa aaaggcctga aggatatggg ctatgggaac    180

tggattagca aaccccagga ggaaaagaac ttttatctct gcccagtata gtatgctcca    240

gtgacagatg gattagggtg tgtcatacta gggtgtgaga gaggtaggtc gtagcattcc    300

tcatcacatg gtcaggggat ttttttttct cctttttttt tctttttaag ccataattgg    360

tgatactgaa aactttgggt tcccatttat cctgctttct ttgggattgc taggcaaggt    420

ctggccaggc cccccttttt tcccccaagt gaagaggcag aaacctaaga agttatcttt    480

tctttctacc caaagcatac atagtcactg agcacctgcg gtccatttcc tcttaaaagt    540

tttgttttga tttgtttcca tttcctttcc ctttgtgttt gctacactga cctcttgcgg    600

tcttgattag gtttcagtca actctggatc atgtcaggga ctgataattt catttgtgga    660

ttacgcagac ccctctactt cccctctttc ccttctgaga ttctttcttg taaaaattgt    720

cagtgcttga agctgtttcc tttactcaca ttgaagggac ttcgttggtt ttttggagtc    780

ttggttgtga ctccaagagc agagtgagga agacccccaa gcatagactc gggtactgtg    840

atgatggctg cagtccagtt ttatgattct gcttttatgt gtcccttgat aacagtgact    900

taacaatata cattcctcat aaataaaaaa aaaacaagaa tctgaattct tag           953


<210>  1251
<211>  58
<212>  PRT
<213>  Homo sapiens

<400>  1251


Met Ser Gly Thr Asp Asn Phe Ile Cys Gly Leu Arg Arg Pro Leu Tyr 
1               5                   10                  15      


Phe Pro Ser Phe Pro Ser Glu Ile Leu Ser Cys Lys Asn Cys Gln Cys 
            20                  25                  30          


Leu Lys Leu Phe Pro Leu Leu Thr Leu Lys Gly Leu Arg Trp Phe Phe 
        35                  40                  45              


Gly Val Leu Val Val Thr Pro Arg Ala Glu 
    50                  55              

<210>  1252
<211>  2158
<212>  DNA
<213>  Homo sapiens

<400>  1252
attgctaggc aaggtctggc caggcccccc ttttttcccc caagtgaaga ggcagaaacc     60

taagaagtta tcttttcttt ctacccaaag catacatagt cactgagcac ctgcggtcca    120

tttcctctta aaagttttgt tttgatttgt ttccatttcc tttccctttg tgtttgctac    180

actgacctct tgcggtcttg attaggtttc agtcaactct ggatcatgtc agggactgat    240

aatttcattt gtggattacg cagacccctc tacttcccct ctttcccttc tgagattctt    300

tccttgtgat ctgaatgtct ccttttcccc ctcagagggc aaagaggtga acataaagga    360

tttggtgaaa catttgtaag ggtaggagtt gaaaactgca gttcccagtg ccacggaagt    420

gtgattggag cctgcagata atgcccagcc atcctcccat cctgcacttt agccagctgc    480

agggcgggca aggcaaggaa agctgcttcc ctggaagtgt atcactttct ccggcagctg    540

ggaagtctag aaccagccag actgggttaa gggagctgct caagcaatag cagaggtttc    600

acccggcagg atgacacaga ccacttccca gggagcacgg gcatgccttg gaatattgcc    660

aagcttccag ctgcctcttc tcctaaagca ttcctaggaa tattttcccc gccaatgctg    720

ggcgtacacc ctagccaacg ggacaaatcc tagagggtat aaaatcatct ctgctcagat    780

aatcatgact tagcaagaat aagggcaaaa aatcctgttg gcttaacgtc actgttccac    840

ccggtgtaat atctctcatg acagtgacac caagggaagt tgactaagtc acatgtaaat    900

taggagtgtt ttaaagaatg ccatagatgt tgtcttcaaa ctctgtgagg tagaatcctt    960

tgtctatacc tccatgaaca ttgactcgtg tgttcagagc ctttggcctc tctgtggagt   1020

ctggctctct ggctcctgtg cattctttga atagtcactc gtaaaaactg tcagtgcttg   1080

aaactgtttc ctttactcat gttgaaggga ctttgttggc ttttagagtg ttggtcatga   1140

ctccaagagc agagcaggga agagcccaag catagacttg gtgccgtggt gatggctgca   1200

gtccagtttt gtgatgctgc ttttacgtgt ccctcgataa cagtcagcta gacacactca   1260

ggaggactac tgaggctctg cgaccttcag gagctgagcc tgcctctctc ctttagatga   1320

cagaccttca tctgggaacg tgctgagcca gcaccctcag atgatttccc tccaaactgc   1380

tgactaggtc atcctctgtc tggtagagac attcacatct ttgcttttat tctatgctct   1440

ctgtactttt gaccaaaaat tgaccaaagt aagaaaatgc aagttctaaa aatagactaa   1500

ggatgccttt gcagaacacc aaagcatccc aaggaactgg tagggaagtg gcgcctgtct   1560

cctggagtgg aagaggcctg ctccctggct ctgggtctgc tgggggcaca gtaaatcagt   1620

cttggcaccc acatccaggg cagagaggtc tgtggttctc agcatcagaa ggcagcgcag   1680

cccctctcct cttcaggcta cagggttgtc acctgctgag tcctcaggtt gtttggcctc   1740

tctggtccat cttgggcatt aggttctcca gcagagctct ggccagctgc ctcttcttta   1800

actgggaaca caggctctca caagatcaga acccccactc acccccaaga tcttatctag   1860

caagcctgta gtattcagtt tctgttgtag gaagagagcg aggcatccct gaattccacg   1920

catctgctgg aaacgagccg tgtcagatcg cacatccctg cgcccccatg cccctctgag   1980

tcacacagga cagaggaggc agagcttctg cccactgtta tcttcacttt ctttgtccag   2040

tcttttgttt ttaataagca gtgaccctcc ctactcttct ttttaatgat ttttgtagtt   2100

gatttgtctg aactgtggct actgtgcatt ccttgaataa tcacttgtaa aaattgtc     2158


<210>  1253
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  1253


Met Pro Leu Gln Asn Thr Lys Ala Ser Gln Gly Thr Gly Arg Glu Val 
1               5                   10                  15      


Ala Pro Val Ser Trp Ser Gly Arg Gly Leu Leu Pro Gly Ser Gly Ser 
            20                  25                  30          


Ala Gly Gly Thr Val Asn Gln Ser Trp His Pro His Pro Gly Gln Arg 
        35                  40                  45              


Gly Leu Trp Phe Ser Ala Ser Glu Gly Ser Ala Ala Pro Leu Leu Phe 
    50                  55                  60                  


Arg Leu Gln Gly Cys His Leu Leu Ser Pro Gln Val Val Trp Pro Leu 
65                  70                  75                  80  


Trp Ser Ile Leu Gly Ile Arg Phe Ser Ser Arg Ala Leu Ala Ser Cys 
                85                  90                  95      


Leu Phe Phe Asn Trp Glu His Arg Leu Ser Gln Asp Gln Asn Pro His 
            100                 105                 110         


Ser Pro Pro Arg Ser Tyr Leu Ala Ser Leu 
        115                 120         

<210>  1254
<211>  3409
<212>  DNA
<213>  Homo sapiens

<400>  1254
gtactcaggt taccttttca gccaagggca tctgacccgt gctatttgct gtcgtgtgac     60

aagagatggg agtgcatttg aggatggact acgacatccc tttattgtca accaccccaa    120

ggtgctataa cccccttcta ttttccctga cattttcctc cttttcaagc agtcatgtaa    180

acagaggaaa aatgtacact gtgggcaagg ggaacattgc ccacagtggt agcccacaag    240

ggaacattgc ccacagtggc ccaccaccaa cattggttgg tctcccaaga acttaaactt    300

tcttcctttt ggatgccaag ggcttttctt ctcttagtct ggaattaatc tgaatcgagg    360

tggagttagt atgtctagag ggtgctcagt cttagccaaa cagaacccta aatacagggg    420

aaagatcatg accccacact tcctctctcc tatgagtctt gagtccctgc ttcagaatct    480

tattcctgaa aggtttccat ctttctcccg ttgcttctgg gattcctagg ttggcagagt    540

cagcatatat gattccaaaa ggcaatccgg gaagactaag gagacaagcg tcaactggtg    600

tctggctgat ggctatgacc tggagatcct ggacggtacc agaggcactg tggatgggcc    660

acggaatgaa ttgtcccggg tctccaaaaa gaacattttt cttctattta agaagctctg    720

ctccttccgt taccgcaggg atctactgag actctcctat ggtgaggcca agaaagctgc    780

ccgtgactac gagacggcca agaactactt caaaaaaggc ctgaaggata tgggctatgg    840

gaactggatt agcaaacccc aggaggaaaa gaacttttat ctctgcccag tatagtatgc    900

tccagtgaca gatggattag ggtgtgtcat actagggtgt gagagaggta ggtcgtagca    960

ttcctcatca catggtcagg ggattttttt ttctcctttt tttttctttt taagccataa   1020

ttggtgatac tgaaaacttt gggttcccat ttatcctgct ttctttggga ttgctaggca   1080

aggtctggcc aggcccccct tttttccccc aagtgaagag gcagaaacct aagaagttat   1140

cttttctttc tacccaaagc atacatagtc actgagcacc tgcggtccat ttcctcttaa   1200

aagttttgtt ttgatttgtt tccatttcct ttccctttgt gtttgctaca ctgacctctt   1260

gcggtcttga ttaggtttca gtcaactctg gatcatgtca gggactgata atttcatttg   1320

tggattacgc agacccctct acttcccctc tttcccttct gagattcttt ccttgtgatc   1380

tgaatgtctc cttttccccc tcagagggca aagaggtgaa cataaaggat ttggtgaaac   1440

atttgtaagg gtaggagttg aaaactgcag ttcccagtgc cacggaagtg tgattggagc   1500

ctgcagataa tgcccagcca tcctcccatc ctgcacttta gccagctgca gggcgggcaa   1560

ggcaaggaaa gctgcttccc tggaagtgta tcactttctc cggcagctgg gaagtctaga   1620

accagccaga ctgggttaag ggagctgctc aagcaatagc agaggtttca cccggcagga   1680

tgacacagac cacttcccag ggagcacggg catgccttgg aatattgcca agcttccagc   1740

tgcctcttct cctaaagcat tcctaggaat attttccccg ccaatgctgg gcgtacaccc   1800

tagccaacgg gacaaatcct agagggtata aaatcatctc tgctcagata atcatgactt   1860

agcaagaata agggcaaaaa atcctgttgg cttaacgtca ctgttccacc cggtgtaata   1920

tctctcatga cagtgacacc aagggaagtt gactaagtca catgtaaatt aggagtgttt   1980

taaagaatgc catagatgtt gattcttaac tgctacagat aacctgtaat tgagcagatt   2040

taaaattcag gcatactttt ccatttatcc aagtgctttc atttttccag atggcttcag   2100

aagtaggctc gtgggcaggg cgcagacctg atctttatag ggttgacata gaaagcagta   2160

gttgtgggtg aaagggcagg ttgtcttcaa actctgtgag gtagaatcct ttgtctatac   2220

ctccatgaac attgactcgt gtgttcagag cctttggcct ctctgtggag tctggctctc   2280

tggctcctgt gcattctttg aatagtcact cgtaaaaact gtcagtgctt gaaactgttt   2340

cctttactca tgttgaaggg actttgttgg cttttagagt gttggtcatg actccaagag   2400

cagagcaggg aagagcccaa gcatagactt ggtgccgtgg tgatggctgc agtccagttt   2460

tgtgatgctg cttttacgtg tccctcgata acagtcagct agacacactc aggaggacta   2520

ctgaggctct gcgaccttca ggagctgagc ctgcctctct cctttagatg acagaccttc   2580

atctgggaac gtgctgagcc agcaccctca gatgatttcc ctccaaactg ctgactaggt   2640

catcctctgt ctggtagaga cattcacatc tttgctttta ttctatgctc tctgtacttt   2700

tgaccaaaaa ttgaccaaag taagaaaatg caagttctaa aaatagacta aggatgcctt   2760

tgcagaacac caaagcatcc caaggaactg gtagggaagt ggcgcctgtc tcctggagtg   2820

gaagaggcct gctccctggc tctgggtctg ctgggggcac agtaaatcag tcttggcacc   2880

cacatccagg gcagagaggt ctgtggttct cagcatcaga aggcagcgca gcccctctcc   2940

tcttcaggct acagggttgt cacctgctga gtcctcaggt tgtttggcct ctctggtcca   3000

tcttgggcat taggttctcc agcagagctc tggccagctg cctcttcttt aactgggaac   3060

acaggctctc acaagatcag aacccccact cacccccaag atcttatcta gcaagcctgt   3120

agtattcagt ttctgttgta ggaagagagc gaggcatccc tgaattccac gcatctgctg   3180

gaaacgagcc gtgtcagatc gcacatccct gcgcccccat gcccctctga gtcacacagg   3240

acagaggagg cagagcttct gcccactgtt atcttcactt tctttgtcca gtcttttgtt   3300

tttaataagc agtgaccctc cctactcttc tttttaatga tttttgtagt tgatttgtct   3360

gaactgtggc tactgtgcat tccttgaata atcacttgta aaaattgtc               3409


<210>  1255
<211>  66
<212>  PRT
<213>  Homo sapiens

<400>  1255


Met Ile Pro Lys Gly Asn Pro Gly Arg Leu Arg Arg Gln Ala Ser Thr 
1               5                   10                  15      


Gly Val Trp Leu Met Ala Met Thr Trp Arg Ser Trp Thr Val Pro Glu 
            20                  25                  30          


Ala Leu Trp Met Gly His Gly Met Asn Cys Pro Gly Ser Pro Lys Arg 
        35                  40                  45              


Thr Phe Phe Phe Tyr Leu Arg Ser Ser Ala Pro Ser Val Thr Ala Gly 
    50                  55                  60                  


Ile Tyr 
65      

<210>  1256
<211>  2382
<212>  DNA
<213>  Homo sapiens

<400>  1256
tactccctgg caaagaaggg caagctacag aaagaggcag gaacaccccc tttgtggaaa     60

atcgcggtct ccactcaggc ttggaaccag cacagcggag tggtaagacc agacggtcat    120

agccaaggag ccccaaactc agacccgagt ttggaaccgg aagacagaaa ctccacatct    180

gtctcagaag atcttcttga gccttttatt gcagtctcag ctcaggcttg gaaccagcac    240

agcggagtgg taagaccaga cagtcatagc caaggatccc caaactcaga cccaggtttg    300

gaacctgaag acagcaactc cacatctgcc ttggaagatc ctcttgagtt tttagacatg    360

gccgagatca aggagaaaat ctgcgactat ctcttcaatg tgtctgactc ctctgccctg    420

aatttggcta aaaatattgg ccttaccaag gcccgagata taaatgctgt gctaattgac    480

atggaaaggc agggggatgt ctatagacaa gggacaaccc ctcccatatg gcatttgaca    540

gacaagaagc gagagaggat gcaaatcaag agaaatacga acagtgttcc tgaaaccgct    600

ccagctgcaa tccctgagac caaaagaaac gcagagttcc tcacctgtaa tatacccaca    660

tcaaatgcct caaataacat ggtaaccaca gaaaaagtgg agaatgggca ggaacctgtc    720

ataaagttag aaaacaggca agaggccaga ccagaaccag caagactgaa accacctgtt    780

cattacaatg gcccctcaaa agcagggtat gttgactttg aaaatggcca gtgggccaca    840

gatgacatcc cagatgactt gaatagtatc cgcgcagcac caggtgagtt tcgagccatc    900

atggagatgc cctccttcta cagtcatggc ttgccacggt gttcacccta caagaaactg    960

acagagtgcc agctgaagaa ccccatcagc gggctgttag aatatgccca gttcgctagt   1020

caaacctgtg agttcaacat gatagagcag agtggaccac cccatgaacc tcgaagtagg   1080

ctcgtgggca gggcgcagac ctgatcttta tagggttgac atagaaagca gtagttgtgg   1140

gtgaaagggc aggttgtctt caaactctgt gaggtagaat cctttgtcta tacctccatg   1200

aacattgact cgtgtgttca gagcctttgg cctctctgtg gagtctggct ctctggctcc   1260

tgtgcattct ttgaatagtc actcgtaaaa actgtcagtg cttgaaactg tttcctttac   1320

tcatgttgaa gggactttgt tggcttttag agtgttggtc atgactccaa gagcagagca   1380

gggaagagcc caagcataga cttggtgccg tggtgatggc tgcagtccag ttttgtgatg   1440

ctgcttttac gtgtccctcg ataacagtca gctagacaca ctcaggagga ctactgaggc   1500

tctgcgacct tcaggagctg agcctgcctc tctcctttag atgacagacc ttcatctggg   1560

aacgtgctga gccagcaccc tcagatgatt tccctccaaa ctgctgacta ggtcatcctc   1620

tgtctggtag agacattcac atctttgctt ttattctatg ctctctgtac ttttgaccaa   1680

aaattgacca aagtaagaaa atgcaagttc taaaaataga ctaaggatgc ctttgcagaa   1740

caccaaagca tcccaaggaa ctggtaggga agtggcgcct gtctcctgga gtggaagagg   1800

cctgctccct ggctctgggt ctgctggggg cacagtaaat cagtcttggc acccacatcc   1860

agggcagaga ggtctgtggt tctcagcatc agaaggcagc gcagcccctc tcctcttcag   1920

gctacagggt tgtcacctgc tgagtcctca ggttgtttgg cctctctggt ccatcttggg   1980

cattaggttc tccagcagag ctctggccag ctgcctcttc tttaactggg aacacaggct   2040

ctcacaagat cagaaccccc actcaccccc aagatcttat ctagcaagcc tgtagtattc   2100

agtttctgtt gtaggaagag agcgaggcat ccctgaattc cacgcatctg ctggaaacga   2160

gccgtgtcag atcgcacatc cctgcgcccc catgcccctc tgagtcacac aggacagagg   2220

aggcagagct tctgcccact gttatcttca ctttctttgt ccagtctttt gtttttaata   2280

agcagtgacc ctccctactc ttctttttaa tgatttttgt agttgatttg tctgaactgt   2340

ggctactgtg cattccttga ataatcactt gtaaaaattg tc                      2382


<210>  1257
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  1257


Met Ala Glu Ile Lys Glu Lys Ile Cys Asp Tyr Leu Phe Asn Val Ser 
1               5                   10                  15      


Asp Ser Ser Ala Leu Asn Leu Ala Lys Asn Ile Gly Leu Thr Lys Ala 
            20                  25                  30          


Arg Asp Ile Asn Ala Val Leu Ile Asp Met Glu Arg Gln Gly Asp Val 
        35                  40                  45              


Tyr Arg Gln Gly Thr Thr Pro Pro Ile Trp His Leu Thr Asp Lys Lys 
    50                  55                  60                  


Arg Glu Arg Met Gln Ile Lys Arg Asn Thr Asn Ser Val Pro Glu Thr 
65                  70                  75                  80  


Ala Pro Ala Ala Ile Pro Glu Thr Lys Arg Asn Ala Glu Phe Leu Thr 
                85                  90                  95      


Cys Asn Ile Pro Thr Ser Asn Ala Ser Asn Asn Met Val Thr Thr Glu 
            100                 105                 110         


Lys Val Glu Asn Gly Gln Glu Pro Val Ile Lys Leu Glu Asn Arg Gln 
        115                 120                 125             


Glu Ala Arg Pro Glu Pro Ala Arg Leu Lys Pro Pro Val His Tyr Asn 
    130                 135                 140                 


Gly Pro Ser Lys Ala Gly Tyr Val Asp Phe Glu Asn Gly Gln Trp Ala 
145                 150                 155                 160 


Thr Asp Asp Ile Pro Asp Asp Leu Asn Ser Ile Arg Ala Ala Pro Gly 
                165                 170                 175     


Glu Phe Arg Ala Ile Met Glu Met Pro Ser Phe Tyr Ser His Gly Leu 
            180                 185                 190         


Pro Arg Cys Ser Pro Tyr Lys Lys Leu Thr Glu Cys Gln Leu Lys Asn 
        195                 200                 205             


Pro Ile Ser Gly Leu Leu Glu Tyr Ala Gln Phe Ala Ser Gln Thr Cys 
    210                 215                 220                 


Glu Phe Asn Met Ile Glu Gln Ser Gly Pro Pro His Glu Pro Arg Ser 
225                 230                 235                 240 


Arg Leu Val Gly Arg Ala Gln Thr 
                245             

<210>  1258
<211>  6306
<212>  DNA
<213>  Homo sapiens

<400>  1258
gaccagacca ttgattcccg actgaaggta gagaaggcta cgtggtgggg gagggtgggg     60

ggagggtcgc ggccgcactg gcagtctccg ggtgtccggc cgtgtcccga ggaagtgcaa    120

gacccggggt attccctcag cggatactac acccatccat ttcaaggcta tgagcacaga    180

cagctcaggt accagcagcc tgggccagga tcttccccca gtagtttcct gcttaagcaa    240

atagaatttc tcaaggggca gctcccagaa gcaccggtga ttggaaagca gacaccgtca    300

ctgccacctt ccctcccagg actccggcca aggtttccag tactacttgc ctccagtacc    360

agaggcaggc aagtggacat caggggtgtc cccaggggcg tgcatctcag aagtcagggg    420

ctccagagag ggttccagca tccttcacca cgtggcagga gtctgccaca gagaggtgtt    480

gattgccttt cctcacattt ccaggaactg agtatctacc aagatcagga acaaaggatc    540

ttaaagttcc tggaagagct tggggaaggg aaggccacca cagcacatga tctgtctggg    600

aaacttggga ctccgaagaa agaaatcaat cgagttttat actccctggc aaagaagggc    660

aagctacaga aagaggcagg aacaccccct ttgtggaaaa tcgcggtctc cactcaggct    720

tggaaccagc acagcggagt ggtaagacca gacggtcata gccaaggagc cccaaactca    780

gacccgagtt tggaaccgga agacagaaac tccacatctg tctcagaaga tcttcttgag    840

ccttttattg cagtctcagc tcaggcttgg aaccagcaca gcggagtggt aagaccagac    900

agtcatagcc aaggatcccc aaactcagac ccaggtttgg aacctgaaga cagcaactcc    960

acatctgcct tggaagatcc tcttgagttt ttagacatgg ccgagatcaa ggagaaaatc   1020

tgcgactatc tcttcaatgt gtctgactcc tctgccctga atttggctaa aaatattggc   1080

cttaccaagg cccgagatat aaatgctgtg ctaattgaca tggaaaggca gggggatgtc   1140

tatagacaag ggacaacccc tcccatatgg catttgacag acaagaagcg agagaggatg   1200

caaatcaaga gaaatacgaa cagtgttcct gaaaccgctc cagctgcaat ccctgagacc   1260

aaaagaaacg cagagttcct cacctgtaat atacccacat caaatgcctc aaataacatg   1320

gtaaccacag aaaaagtgga gaatgggcag gaacctgtca taaagttaga aaacaggcaa   1380

gaggccagac cagaaccagc aagactgaaa ccacctgttc attacaatgg cccctcaaaa   1440

gcagggtatg ttgactttga aaatggccag tgggccacag atgacatccc agatgacttg   1500

aatagtatcc gcgcagcacc aggtgagttt cgagccatca tggagatgcc ctccttctac   1560

agtcatggct tgccacggtg ttcaccctac aagaaactga cagagtgcca gctgaagaac   1620

cccatcagcg ggctgttaga atatgcccag ttcgctagtc aaacctgtga gttcaacatg   1680

atagagcaga gtggaccacc ccatgaacct cgatttaaat tccaggttgt catcaatggc   1740

cgagagtttc ccccagctga agctggaagc aagaaagtgg ccaagcagga tgcagctatg   1800

aaagccatga caattctgct agaggaagcc aaagccaagg acagtggaaa atcagaagaa   1860

tcatcccact attccacaga gaaagaatca gagaagactg cagagtccca gacccccacc   1920

ccttcagcca catccttctt ttctgggaag agccccgtca ccacactgct tgagtgtatg   1980

cacaaattgg ggaactcctg cgaattccgt ctcctgtcca aagaaggccc tgcccatgaa   2040

cccaagttcc aatactgtgt tgcagtggga gcccaaactt tccccagtgt gagtgctccc   2100

agcaagaaag tggcaaagca gatggccgca gaggaagcca tgaaggccct gcatggggag   2160

gcgaccaact ccatggcttc tgataaccag cctgaaggta tgatctcaga gtcacttgat   2220

aacttggaat ccatgatgcc caacaaggtc aggaagattg gcgagctcgt gagatacctg   2280

aacaccaacc ctgtgggtgg ccttttggag tacgcccgct cccatggctt tgctgctgaa   2340

ttcaagttgg tcgaccagtc cggacctcct cacgagccca agttcgttta ccaagcaaaa   2400

gttgggggtc gctggttccc agccgtctgc gcacacagca agaagcaagg caagcaggaa   2460

gcagcagatg cggctctccg tgtcttgatt ggggagaacg agaaggcaga acgcatgggt   2520

ttcacagagg taaccccagt gacaggggcc agtctcagaa gaactatgct cctcctctca   2580

aggtccccag aagcacagcc aaagacactc cctctcactg gcagcacctt ccatgaccag   2640

atagccatgc tgagccaccg gtgcttcaac actctgacta acagcttcca gccctccttg   2700

ctcggccgca agattctggc cgccatcatt atgaaaaaag actctgagga catgggtgtc   2760

gtcgtcagct tgggaacagg gaatcgctgt gtgaaaggag attctctcag cctaaaagga   2820

gaaactgtca atgactgcca tgcagaaata atctcccgga gaggcttcat caggtttctc   2880

tacagtgagt taatgaaata caactcccag actgcgaagg atagtatatt tgaacctgct   2940

aagggaggag aaaagctcca aataaaaaag actgtgtcat tccatctgta tatcagcact   3000

gctccgtgtg gagatggcgc cctctttgac aagtcctgca gcgaccgtgc tatggaaagc   3060

acagaatccc gccactaccc tgtcttcgag aatcccaaac aaggaaagct ccgcaccaag   3120

gtggagaacg gagaaggcac aatccctgtg gaatccagtg acattgtgcc tacgtgggat   3180

ggcattcggc tcggggagag actccgtacc atgtcctgta gtgacaaaat cctacgctgg   3240

aacgtgctgg gcctgcaagg ggcactgttg acccacttcc tgcagcccat ttatctcaaa   3300

tctgtcacat tgggttacct tttcagccaa gggcatctga cccgtgctat ttgctgtcgt   3360

gtgacaagag atgggagtgc atttgaggat ggactacgac atccctttat tgtcaaccac   3420

cccaaggttg gcagagtcag catatatgat tccaaaaggc aatccgggaa gactaaggag   3480

acaagcgtca actggtgtct ggctgatggc tatgacctgg agatcctgga cggtaccaga   3540

ggcactgtgg atgggccacg gaatgaattg tcccgggtct ccaaaaagaa catttttctt   3600

ctatttaaga agctctgctc cttccgttac cgcagggatc tactgagact ctcctatggt   3660

gaggccaaga aagctgcccg tgactacgag acggccaaga actacttcaa aaaaggcctg   3720

aaggatatgg gctatgggaa ctggattagc aaaccccagg aggaaaagaa cttttatctc   3780

tgcccagtat agtatgctcc agtgacagat ggattagggt gtgtcatact agggtgtgag   3840

agaggtaggt cgtagcattc ctcatcacat ggtcagggga tttttttttc tccttttttt   3900

ttctttttaa gccataattg gtgatactga aaactttggg ttcccattta tcctgctttc   3960

tttgggattg ctaggcaagg tctggccagg cccccctttt ttcccccaag tgaagaggca   4020

gaaacctaag aagttatctt ttctttctac ccaaagcata catagtcact gagcacctgc   4080

ggtccatttc ctcttaaaag ttttgttttg atttgtttcc atttcctttc cctttgtgtt   4140

tgctacactg acctcttgcg gtcttgatta ggtttcagtc aactctggat catgtcaggg   4200

actgataatt tcatttgtgg attacgcaga cccctctact tcccctcttt cccttctgag   4260

attctttcct tgtgatctga atgtctcctt ttccccctca gagggcaaag aggtgaacat   4320

aaaggatttg gtgaaacatt tgtaagggta ggagttgaaa actgcagttc ccagtgccac   4380

ggaagtgtga ttggagcctg cagataatgc ccagccatcc tcccatcctg cactttagcc   4440

agctgcaggg cgggcaaggc aaggaaagct gcttccctgg aagtgtatca ctttctccgg   4500

cagctgggaa gtctagaacc agccagactg ggttaaggga gctgctcaag caatagcaga   4560

ggtttcaccc ggcaggatga cacagaccac ttcccaggga gcacgggcat gccttggaat   4620

attgccaagc ttccagctgc ctcttctcct aaagcattcc taggaatatt ttccccgcca   4680

atgctgggcg tacaccctag ccaacgggac aaatcctaga gggtataaaa tcatctctgc   4740

tcagataatc atgacttagc aagaataagg gcaaaaaatc ctgttggctt aacgtcactg   4800

ttccacccgg tgtaatatct ctcatgacag tgacaccaag ggaagttgac taagtcacat   4860

gtaaattagg agtgttttaa agaatgccat agatgttgat tcttaactgc tacagataac   4920

ctgtaattga gcagatttaa aattcaggca tacttttcca tttatccaag tgctttcatt   4980

tttccagatg gcttcagaag taggctcgtg ggcagggcgc agacctgatc tttatagggt   5040

tgacatagaa agcagtagtt gtgggtgaaa gggcaggttg tcttcaaact ctgtgaggta   5100

gaatcctttg tctatacctc catgaacatt gactcgtgtg ttcagagcct ttggcctctc   5160

tgtggagtct ggctctctgg ctcctgtgca ttctttgaat agtcactcgt aaaaactgtc   5220

agtgcttgaa actgtttcct ttactcatgt tgaagggact ttgttggctt ttagagtgtt   5280

ggtcatgact ccaagagcag agcagggaag agcccaagca tagacttggt gccgtggtga   5340

tggctgcagt ccagttttgt gatgctgctt ttacgtgtcc ctcgataaca gtcagctaga   5400

cacactcagg aggactactg aggctctgcg accttcagga gctgagcctg cctctctcct   5460

ttagatgaca gaccttcatc tgggaacgtg ctgagccagc accctcagat gatttccctc   5520

caaactgctg actaggtcat cctctgtctg gtagagacat tcacatcttt gcttttattc   5580

tatgctctct gtacttttga ccaaaaattg accaaagtaa gaaaatgcaa gttctaaaaa   5640

tagactaagg atgcctttgc agaacaccaa agcatcccaa ggaactggta gggaagtggc   5700

gcctgtctcc tggagtggaa gaggcctgct ccctggctct gggtctgctg ggggcacagt   5760

aaatcagtct tggcacccac atccagggca gagaggtctg tggttctcag catcagaagg   5820

cagcgcagcc cctctcctct tcaggctaca gggttgtcac ctgctgagtc ctcaggttgt   5880

ttggcctctc tggtccatct tgggcattag gttctccagc agagctctgg ccagctgcct   5940

cttctttaac tgggaacaca ggctctcaca agatcagaac ccccactcac ccccaagatc   6000

ttatctagca agcctgtagt attcagtttc tgttgtagga agagagcgag gcatccctga   6060

attccacgca tctgctggaa acgagccgtg tcagatcgca catccctgcg cccccatgcc   6120

cctctgagtc acacaggaca gaggaggcag agcttctgcc cactgttatc ttcactttct   6180

ttgtccagtc ttttgttttt aataagcagt gaccctccct actcttcttt ttaatgattt   6240

ttgtagttga tttgtctgaa ctgtggctac tgtgcattcc ttgaataatc acttgtaaaa   6300

attgtc                                                              6306


<210>  1259
<211>  931
<212>  PRT
<213>  Homo sapiens

<400>  1259


Met Ala Glu Ile Lys Glu Lys Ile Cys Asp Tyr Leu Phe Asn Val Ser 
1               5                   10                  15      


Asp Ser Ser Ala Leu Asn Leu Ala Lys Asn Ile Gly Leu Thr Lys Ala 
            20                  25                  30          


Arg Asp Ile Asn Ala Val Leu Ile Asp Met Glu Arg Gln Gly Asp Val 
        35                  40                  45              


Tyr Arg Gln Gly Thr Thr Pro Pro Ile Trp His Leu Thr Asp Lys Lys 
    50                  55                  60                  


Arg Glu Arg Met Gln Ile Lys Arg Asn Thr Asn Ser Val Pro Glu Thr 
65                  70                  75                  80  


Ala Pro Ala Ala Ile Pro Glu Thr Lys Arg Asn Ala Glu Phe Leu Thr 
                85                  90                  95      


Cys Asn Ile Pro Thr Ser Asn Ala Ser Asn Asn Met Val Thr Thr Glu 
            100                 105                 110         


Lys Val Glu Asn Gly Gln Glu Pro Val Ile Lys Leu Glu Asn Arg Gln 
        115                 120                 125             


Glu Ala Arg Pro Glu Pro Ala Arg Leu Lys Pro Pro Val His Tyr Asn 
    130                 135                 140                 


Gly Pro Ser Lys Ala Gly Tyr Val Asp Phe Glu Asn Gly Gln Trp Ala 
145                 150                 155                 160 


Thr Asp Asp Ile Pro Asp Asp Leu Asn Ser Ile Arg Ala Ala Pro Gly 
                165                 170                 175     


Glu Phe Arg Ala Ile Met Glu Met Pro Ser Phe Tyr Ser His Gly Leu 
            180                 185                 190         


Pro Arg Cys Ser Pro Tyr Lys Lys Leu Thr Glu Cys Gln Leu Lys Asn 
        195                 200                 205             


Pro Ile Ser Gly Leu Leu Glu Tyr Ala Gln Phe Ala Ser Gln Thr Cys 
    210                 215                 220                 


Glu Phe Asn Met Ile Glu Gln Ser Gly Pro Pro His Glu Pro Arg Phe 
225                 230                 235                 240 


Lys Phe Gln Val Val Ile Asn Gly Arg Glu Phe Pro Pro Ala Glu Ala 
                245                 250                 255     


Gly Ser Lys Lys Val Ala Lys Gln Asp Ala Ala Met Lys Ala Met Thr 
            260                 265                 270         


Ile Leu Leu Glu Glu Ala Lys Ala Lys Asp Ser Gly Lys Ser Glu Glu 
        275                 280                 285             


Ser Ser His Tyr Ser Thr Glu Lys Glu Ser Glu Lys Thr Ala Glu Ser 
    290                 295                 300                 


Gln Thr Pro Thr Pro Ser Ala Thr Ser Phe Phe Ser Gly Lys Ser Pro 
305                 310                 315                 320 


Val Thr Thr Leu Leu Glu Cys Met His Lys Leu Gly Asn Ser Cys Glu 
                325                 330                 335     


Phe Arg Leu Leu Ser Lys Glu Gly Pro Ala His Glu Pro Lys Phe Gln 
            340                 345                 350         


Tyr Cys Val Ala Val Gly Ala Gln Thr Phe Pro Ser Val Ser Ala Pro 
        355                 360                 365             


Ser Lys Lys Val Ala Lys Gln Met Ala Ala Glu Glu Ala Met Lys Ala 
    370                 375                 380                 


Leu His Gly Glu Ala Thr Asn Ser Met Ala Ser Asp Asn Gln Pro Glu 
385                 390                 395                 400 


Gly Met Ile Ser Glu Ser Leu Asp Asn Leu Glu Ser Met Met Pro Asn 
                405                 410                 415     


Lys Val Arg Lys Ile Gly Glu Leu Val Arg Tyr Leu Asn Thr Asn Pro 
            420                 425                 430         


Val Gly Gly Leu Leu Glu Tyr Ala Arg Ser His Gly Phe Ala Ala Glu 
        435                 440                 445             


Phe Lys Leu Val Asp Gln Ser Gly Pro Pro His Glu Pro Lys Phe Val 
    450                 455                 460                 


Tyr Gln Ala Lys Val Gly Gly Arg Trp Phe Pro Ala Val Cys Ala His 
465                 470                 475                 480 


Ser Lys Lys Gln Gly Lys Gln Glu Ala Ala Asp Ala Ala Leu Arg Val 
                485                 490                 495     


Leu Ile Gly Glu Asn Glu Lys Ala Glu Arg Met Gly Phe Thr Glu Val 
            500                 505                 510         


Thr Pro Val Thr Gly Ala Ser Leu Arg Arg Thr Met Leu Leu Leu Ser 
        515                 520                 525             


Arg Ser Pro Glu Ala Gln Pro Lys Thr Leu Pro Leu Thr Gly Ser Thr 
    530                 535                 540                 


Phe His Asp Gln Ile Ala Met Leu Ser His Arg Cys Phe Asn Thr Leu 
545                 550                 555                 560 


Thr Asn Ser Phe Gln Pro Ser Leu Leu Gly Arg Lys Ile Leu Ala Ala 
                565                 570                 575     


Ile Ile Met Lys Lys Asp Ser Glu Asp Met Gly Val Val Val Ser Leu 
            580                 585                 590         


Gly Thr Gly Asn Arg Cys Val Lys Gly Asp Ser Leu Ser Leu Lys Gly 
        595                 600                 605             


Glu Thr Val Asn Asp Cys His Ala Glu Ile Ile Ser Arg Arg Gly Phe 
    610                 615                 620                 


Ile Arg Phe Leu Tyr Ser Glu Leu Met Lys Tyr Asn Ser Gln Thr Ala 
625                 630                 635                 640 


Lys Asp Ser Ile Phe Glu Pro Ala Lys Gly Gly Glu Lys Leu Gln Ile 
                645                 650                 655     


Lys Lys Thr Val Ser Phe His Leu Tyr Ile Ser Thr Ala Pro Cys Gly 
            660                 665                 670         


Asp Gly Ala Leu Phe Asp Lys Ser Cys Ser Asp Arg Ala Met Glu Ser 
        675                 680                 685             


Thr Glu Ser Arg His Tyr Pro Val Phe Glu Asn Pro Lys Gln Gly Lys 
    690                 695                 700                 


Leu Arg Thr Lys Val Glu Asn Gly Glu Gly Thr Ile Pro Val Glu Ser 
705                 710                 715                 720 


Ser Asp Ile Val Pro Thr Trp Asp Gly Ile Arg Leu Gly Glu Arg Leu 
                725                 730                 735     


Arg Thr Met Ser Cys Ser Asp Lys Ile Leu Arg Trp Asn Val Leu Gly 
            740                 745                 750         


Leu Gln Gly Ala Leu Leu Thr His Phe Leu Gln Pro Ile Tyr Leu Lys 
        755                 760                 765             


Ser Val Thr Leu Gly Tyr Leu Phe Ser Gln Gly His Leu Thr Arg Ala 
    770                 775                 780                 


Ile Cys Cys Arg Val Thr Arg Asp Gly Ser Ala Phe Glu Asp Gly Leu 
785                 790                 795                 800 


Arg His Pro Phe Ile Val Asn His Pro Lys Val Gly Arg Val Ser Ile 
                805                 810                 815     


Tyr Asp Ser Lys Arg Gln Ser Gly Lys Thr Lys Glu Thr Ser Val Asn 
            820                 825                 830         


Trp Cys Leu Ala Asp Gly Tyr Asp Leu Glu Ile Leu Asp Gly Thr Arg 
        835                 840                 845             


Gly Thr Val Asp Gly Pro Arg Asn Glu Leu Ser Arg Val Ser Lys Lys 
    850                 855                 860                 


Asn Ile Phe Leu Leu Phe Lys Lys Leu Cys Ser Phe Arg Tyr Arg Arg 
865                 870                 875                 880 


Asp Leu Leu Arg Leu Ser Tyr Gly Glu Ala Lys Lys Ala Ala Arg Asp 
                885                 890                 895     


Tyr Glu Thr Ala Lys Asn Tyr Phe Lys Lys Gly Leu Lys Asp Met Gly 
            900                 905                 910         


Tyr Gly Asn Trp Ile Ser Lys Pro Gln Glu Glu Lys Asn Phe Tyr Leu 
        915                 920                 925             


Cys Pro Val 
    930     

<210>  1260
<211>  1858
<212>  DNA
<213>  Homo sapiens

<400>  1260
agcaccggtg attggaaagc agacaccgtc actgccacct tccctcccag gactccggcc     60

aaggtttcca gtactacttg cctccagtac cagaggcagg aactgagtat ctaccaagat    120

caggaacaaa ggatcttaaa gttcctggaa gagcttgggg aagggaaggc caccacagca    180

catgatctgt ctgggaaact tgggactccg aagaaagaaa tcaatcgagt tttatactcc    240

ctggcaaaga agggcaagct acagaaagag gcaggaacac cccctttgtg gaaaatcgcg    300

gtctccactc aggcttggaa ccagcacagc ggagtggtaa gaccagacgg tcatagccaa    360

ggagccccaa actcagaccc gagtttggaa ccggaagaca gaaactccac atctgtctca    420

gaagatcttc ttgagccttt tattgcagtc tcagctcagg cttggaacca gcacagcgga    480

gtggtaagac cagacagtca tagccaagga tccccaaact cagacccagg tttggaacct    540

gaagacagca actccacatc tgccttggaa gatcctcttg agtttttaga catggccgag    600

atcaaggaga aaatctgcga ctatctcttc aatgtgtctg actcctctgc cctgaatttg    660

gctaaaaata ttggccttac caaggcccga gatataaatg ctgtgctaat tgacatggaa    720

aggcaggggg atgtctatag acaagggaca acccctccca tatggcattt gacagacaag    780

aagcgagaga ggatgcaaat caagagaaat acgaacagtg ttcctgaaac cgctccagct    840

gcaatccctg agaccaaaag aaacgcagag ttcctcacct gtaatatacc cacatcaaat    900

gcctcaaata acatggtaac cacagaaaaa gtggagaatg ggcaggaacc tgtcataaag    960

ttagaaaaca ggcaagaggc cagaccagaa ccagcaagac tgaaaccacc tgttcattac   1020

aatggcccct caaaagcagg gtatgttgac tttgaaaatg gccagtgggc cacagatgac   1080

atcccagatg acttgaatag tatccgcgca gcaccaggtg agtttcgagc catcatggag   1140

atgccctcct tctacagtca tggcttgcca cggtgttcac cctacaagaa actgacagag   1200

tgccagctga agaaccccat cagcgggctg ttagaatatg cccagttcgc tagtcaaacc   1260

tgtgagttca acatgataga gcagagtgga ccaccccatg aacctcggta agagaccacc   1320

caggaactgt acctagggtt ggggtcaggt gcttttgctc ctgacgcagt cttggctgat   1380

ttgtgagcag tgctgtttgg tggcgcctat cttttcctcc ttcccttctg ccttttagct   1440

aaattcccct tgattggccc tttctccaga tattgagcag ggaatataga ccttggacca   1500

gccagaatct tggctgaaca agggggaggt tgactctgtt ggctgtaatg aagcttcttt   1560

agaaatgatt ggttttggcc gtacgcggtg gctcatgcct gtaatcccag cactttttga   1620

ggccgaggca ggcatatcac gaggtcagga gtttgagacc agcctggcca acatggtgaa   1680

accctgtctc tactaaaaat acaaaaatta gctgggcgtg gtggcgtgca cctgtagtcc   1740

cagctactca ggaagctgag acaggagaat cacttgaacc caggaggcag aggttgcagt   1800

gaactgagat tgcgccactg cactccagcc tgggccacag agcaagactc catctcaa     1858


<210>  1261
<211>  239
<212>  PRT
<213>  Homo sapiens

<400>  1261


Met Ala Glu Ile Lys Glu Lys Ile Cys Asp Tyr Leu Phe Asn Val Ser 
1               5                   10                  15      


Asp Ser Ser Ala Leu Asn Leu Ala Lys Asn Ile Gly Leu Thr Lys Ala 
            20                  25                  30          


Arg Asp Ile Asn Ala Val Leu Ile Asp Met Glu Arg Gln Gly Asp Val 
        35                  40                  45              


Tyr Arg Gln Gly Thr Thr Pro Pro Ile Trp His Leu Thr Asp Lys Lys 
    50                  55                  60                  


Arg Glu Arg Met Gln Ile Lys Arg Asn Thr Asn Ser Val Pro Glu Thr 
65                  70                  75                  80  


Ala Pro Ala Ala Ile Pro Glu Thr Lys Arg Asn Ala Glu Phe Leu Thr 
                85                  90                  95      


Cys Asn Ile Pro Thr Ser Asn Ala Ser Asn Asn Met Val Thr Thr Glu 
            100                 105                 110         


Lys Val Glu Asn Gly Gln Glu Pro Val Ile Lys Leu Glu Asn Arg Gln 
        115                 120                 125             


Glu Ala Arg Pro Glu Pro Ala Arg Leu Lys Pro Pro Val His Tyr Asn 
    130                 135                 140                 


Gly Pro Ser Lys Ala Gly Tyr Val Asp Phe Glu Asn Gly Gln Trp Ala 
145                 150                 155                 160 


Thr Asp Asp Ile Pro Asp Asp Leu Asn Ser Ile Arg Ala Ala Pro Gly 
                165                 170                 175     


Glu Phe Arg Ala Ile Met Glu Met Pro Ser Phe Tyr Ser His Gly Leu 
            180                 185                 190         


Pro Arg Cys Ser Pro Tyr Lys Lys Leu Thr Glu Cys Gln Leu Lys Asn 
        195                 200                 205             


Pro Ile Ser Gly Leu Leu Glu Tyr Ala Gln Phe Ala Ser Gln Thr Cys 
    210                 215                 220                 


Glu Phe Asn Met Ile Glu Gln Ser Gly Pro Pro His Glu Pro Arg 
225                 230                 235                 

<210>  1262
<211>  972
<212>  DNA
<213>  Homo sapiens

<400>  1262
gcgaagacct ggagaagcag attggcagcc tggagtcgaa gctggagcat ctcaccgcca     60

gcttcaactc cctgccgctg ctcatcgccg acaccctgcg ccagcagcag cagcagctcc    120

tgtctgccat catcgaggcc cggggtgtca gcgtggcagt gggcaccacc cacaccccaa    180

tctccgatag ccccattggg gtgcctctac ttgggagcgg gaagaggaga tgacaggaag    240

cgacgcctct ggcagggccc ttgctgcaga gttggtggag aacagaaatc cacgctcaat    300

ctcaggtgcc aagtgccctg tgacagttgt ttacacacct gaaaaatgta tcctggaagc    360

tgtaatcttg ggcctgggct atgtgttgaa acaagcaaaa gagacacatc gtgaccaacc    420

aagctggtgg aggaaaagca caaaattcaa ctccaacctg cagttaggat cccaaagaga    480

tgttgacatt tatagccaaa aagaaaaagt acatatatat atatatatat atatatatat    540

atatatatat atatatatat ctgaatcaga tcgaagcagc caacgtccag cttcactcaa    600

gaaggacaag gaataaacaa cattctctag ctgtgtcatg ttgtctcagt ttttgaatct    660

caaccaggac tgatccacct tcatcagata cgttttttaa tggcgcaaca actcaatttt    720

ggtcccagac tctccattct gcactggcca cgagaacaac aagagaatga caggatgtta    780

atggaggaaa cattttcatg gcaagctcag aaactgaagt gtttatattc agaatcagat    840

gagctttaat atgaatttgc atcttgcctc tgtactgctt gctatttttt aatgatagga    900

gaaagcataa cagtttattt taaatatgaa atatattgat atattataaa atatattgta    960

actttcaatt aa                                                        972


<210>  1263
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  1263


Met Thr Gly Ser Asp Ala Ser Gly Arg Ala Leu Ala Ala Glu Leu Val 
1               5                   10                  15      


Glu Asn Arg Asn Pro Arg Ser Ile Ser Gly Ala Lys Cys Pro Val Thr 
            20                  25                  30          


Val Val Tyr Thr Pro Glu Lys Cys Ile Leu Glu Ala Val Ile Leu Gly 
        35                  40                  45              


Leu Gly Tyr Val Leu Lys Gln Ala Lys Glu Thr His Arg Asp Gln Pro 
    50                  55                  60                  


Ser Trp Trp Arg Lys Ser Thr Lys Phe Asn Ser Asn Leu Gln Leu Gly 
65                  70                  75                  80  


Ser Gln Arg Asp Val Asp Ile Tyr Ser Gln Lys Glu Lys Val His Ile 
                85                  90                  95      


Tyr Ile Tyr Ile Tyr Ile Tyr Ile Tyr Ile Tyr Ile Tyr Ile Ser Glu 
            100                 105                 110         


Ser Asp Arg Ser Ser Gln Arg Pro Ala Ser Leu Lys Lys Asp Lys Glu 
        115                 120                 125             

<210>  1264
<211>  2893
<212>  DNA
<213>  Homo sapiens

<400>  1264
ctgctcagtg tcaaattaac aggaaagtca gcttaaagga cactccttgc agggactgag     60

ctggcaccta ctccttagag cttgctgata ccaggcctgc cacgcgacat ctgcaaggac    120

agttgtttgg tgttttgctt caggttatag atggagagac ctataaagga ctccatgttt    180

tcgttggccc tgaaatgcct tatcagtctg tccaccatca tccttttggg cttgatcatc    240

gcctaccaca cacgtgaagt ccagctcttc gtgatcgaca atggcgcgga tgactggcgg    300

atagccatga cctacgagcg catcctgtac atcagcctgg agatgctggt gtgcgccatc    360

caccccattc ctggcgagta caagttcttc tggacggcac gcctggcctt ctcctacaca    420

ccctcccggg cggaggccga tgtggacatc atcctgtcta tccccatgtt cctgcgcctg    480

tacctgatcg cccgagtcat gctgctgcac agcaagctct tcaccgatgc ctcgtcccgc    540

agcatcgggg ccctcaacaa gatcaacttc aacacccgct ttgtcatgaa gacgctcatg    600

accatctgcc ctggcactgt gctgctcgtg ttcagcatct ctctgtggat cattgctgcc    660

tggaccgtcc gtgtctgtga aaggtaccat gaccagcagg acgtaactag taactttctg    720

ggtgccatgt ggctcatctc catcacattc ctttccattg gttatgggga catggtgccc    780

cacacatact gtgggaaagg tgtctgtctc ctcactggca tcatgggtgc aggctgcact    840

gcccttgtgg tggccgtggt ggcccgaaag ctggaactca ccaaagcgga gaagcacgtt    900

cataacttca tgatggacac tcagctcacc aagcggatca agaatgctgc agccaatgtc    960

cttcgggaaa catggttaat ctataaacac acaaagctgc taaagaagat tgaccatgcc   1020

aaagtgagga aacaccagag gaagttcctc caagctatcc accagttgag gagcgtcaag   1080

atggaacaga ggaagctgag tgaccaagcc aacactctgg tggacctttc caagatgcag   1140

aatgtcatgt atgacttaat cacagaactc aatgaccgga gcgaagacct ggagaagcag   1200

attggcagcc tggagtcgaa gctggagcat ctcaccgcca gcttcaactc cctgccgctg   1260

ctcatcgccg acaccctgcg ccagcagcag cagcagctcc tgtctgccat catcgaggcc   1320

cggggtgtca gcgtggcagt gggcaccacc cacaccccaa tctccgatag ccccattggg   1380

gtcagctcca cctccttccc gaccccgtac acaagttcaa gcagttgcta aataaatctc   1440

cccactccag aagcattacc cataggtctt aagatgcaaa tcaactctct cctggtcgct   1500

ttgccatcaa gaaacattca gaccagggaa cggaaagaag agagaccgag ctaattaact   1560

aactcatgtt cattcagcgt gcttggtccg acatgccttg aaaccagaaa tctaatctct   1620

gtttaggtgc ctctacttgg gagcgggaag aggagatgac aggaagcgac gcctctggca   1680

gggcccttgc tgcagagttg gtggagaaca gaaatccacg ctcaatctca ggtcttcacg   1740

cggggggtgg gggtcagatg cactgaagta gccaacagcg aagccagtcc agaagagggg   1800

tccgctggga gggagggttg tgtcaggctt gggggatggg ctcttcgcca tgggggtctt   1860

tgaacacacc tctctccttt ccttttgtct acggaagcct ctgggtgaca aaagtaaaag   1920

agagctgccc acaacttgcc aaaacagata tactcgaatc agactgaaaa aaaaaaaaaa   1980

agacacagac aaataaaaag ccagattttc cactcgatat taatacccac ataaacctgt   2040

gtgtttgcaa acgtgtacat gtacacacat acacatccca cgttcgcttc aggtcctttc   2100

ttatttgagc ttaatccaaa taaaaaggga cttgacacct taccctgcat acaataggca   2160

ccccttacat gtgttttgag ttggtctgaa tctgaacatg gggtgctttc agttcaggta   2220

gttagctagt tctggccaca ttctgagttt cactgaagat gtggatccct tcagacataa   2280

tgcacattgc tttgtcctgg atatgcacct tgcttgattt gaaatggatg ccaagccaaa   2340

attgttggca ttcaggaggg ataagcaggc ttctaaaaat aacagcatct gcagagtttt   2400

cttcttccat ccaaacaagt tgtgtttcga tggtccacat gaccaggtgt atgtctgtaa   2460

gtgtggaggg agaggacaag aaattgtgca tgtgtgtgca gacatgcaca aacaggagca   2520

atccaataac accttagtga atagaaatat ggttggggat ttgctgagct gtatttatcc   2580

agcaacaggt ttccagcccc agatgttagt agtgcaaaag ggccaagtgc ctcaattgtg   2640

agcctctgag ctaggaggag aagtgatgaa gagtggccta tgtggtccct tctacctgac   2700

cttaagtcat ctcaaaatga aatattgtga gaatgaaggg aacccttagg gaaccttgtg   2760

ggtaaggtaa gtggacatgg atttgtcagt agcctgttcc tactgtgcca tgttaatctt   2820

ggtgcgaaaa actattccaa tacatctcaa actccaagag acttcagaaa catcaagatt   2880

tagtgtaatg agc                                                      2893


<210>  1265
<211>  426
<212>  PRT
<213>  Homo sapiens

<400>  1265


Met Glu Arg Pro Ile Lys Asp Ser Met Phe Ser Leu Ala Leu Lys Cys 
1               5                   10                  15      


Leu Ile Ser Leu Ser Thr Ile Ile Leu Leu Gly Leu Ile Ile Ala Tyr 
            20                  25                  30          


His Thr Arg Glu Val Gln Leu Phe Val Ile Asp Asn Gly Ala Asp Asp 
        35                  40                  45              


Trp Arg Ile Ala Met Thr Tyr Glu Arg Ile Leu Tyr Ile Ser Leu Glu 
    50                  55                  60                  


Met Leu Val Cys Ala Ile His Pro Ile Pro Gly Glu Tyr Lys Phe Phe 
65                  70                  75                  80  


Trp Thr Ala Arg Leu Ala Phe Ser Tyr Thr Pro Ser Arg Ala Glu Ala 
                85                  90                  95      


Asp Val Asp Ile Ile Leu Ser Ile Pro Met Phe Leu Arg Leu Tyr Leu 
            100                 105                 110         


Ile Ala Arg Val Met Leu Leu His Ser Lys Leu Phe Thr Asp Ala Ser 
        115                 120                 125             


Ser Arg Ser Ile Gly Ala Leu Asn Lys Ile Asn Phe Asn Thr Arg Phe 
    130                 135                 140                 


Val Met Lys Thr Leu Met Thr Ile Cys Pro Gly Thr Val Leu Leu Val 
145                 150                 155                 160 


Phe Ser Ile Ser Leu Trp Ile Ile Ala Ala Trp Thr Val Arg Val Cys 
                165                 170                 175     


Glu Arg Tyr His Asp Gln Gln Asp Val Thr Ser Asn Phe Leu Gly Ala 
            180                 185                 190         


Met Trp Leu Ile Ser Ile Thr Phe Leu Ser Ile Gly Tyr Gly Asp Met 
        195                 200                 205             


Val Pro His Thr Tyr Cys Gly Lys Gly Val Cys Leu Leu Thr Gly Ile 
    210                 215                 220                 


Met Gly Ala Gly Cys Thr Ala Leu Val Val Ala Val Val Ala Arg Lys 
225                 230                 235                 240 


Leu Glu Leu Thr Lys Ala Glu Lys His Val His Asn Phe Met Met Asp 
                245                 250                 255     


Thr Gln Leu Thr Lys Arg Ile Lys Asn Ala Ala Ala Asn Val Leu Arg 
            260                 265                 270         


Glu Thr Trp Leu Ile Tyr Lys His Thr Lys Leu Leu Lys Lys Ile Asp 
        275                 280                 285             


His Ala Lys Val Arg Lys His Gln Arg Lys Phe Leu Gln Ala Ile His 
    290                 295                 300                 


Gln Leu Arg Ser Val Lys Met Glu Gln Arg Lys Leu Ser Asp Gln Ala 
305                 310                 315                 320 


Asn Thr Leu Val Asp Leu Ser Lys Met Gln Asn Val Met Tyr Asp Leu 
                325                 330                 335     


Ile Thr Glu Leu Asn Asp Arg Ser Glu Asp Leu Glu Lys Gln Ile Gly 
            340                 345                 350         


Ser Leu Glu Ser Lys Leu Glu His Leu Thr Ala Ser Phe Asn Ser Leu 
        355                 360                 365             


Pro Leu Leu Ile Ala Asp Thr Leu Arg Gln Gln Gln Gln Gln Leu Leu 
    370                 375                 380                 


Ser Ala Ile Ile Glu Ala Arg Gly Val Ser Val Ala Val Gly Thr Thr 
385                 390                 395                 400 


His Thr Pro Ile Ser Asp Ser Pro Ile Gly Val Ser Ser Thr Ser Phe 
                405                 410                 415     


Pro Thr Pro Tyr Thr Ser Ser Ser Ser Cys 
            420                 425     

<210>  1266
<211>  3096
<212>  DNA
<213>  Homo sapiens

<400>  1266
gaggactcag aataaacctg ctgctgcttc gtaaacatct cctgataaaa atggctacag     60

gtgttacctg ggcagagcag ctgggcgccg ccttggaatc agctggggga gcacctctcc    120

ttgggacggg atgacagggc ttcccaggcg gtccccacaa gcccgcgccc cagctcagcc    180

ccagttctcc cctcccacct caactcctcc ttgggataaa taaagatgag tgtgtgtgtg    240

agtgcgcgcc cggatggaga acagcaggca ctggctttag cggggagctg gccccactgc    300

tccagcctct cagtccagcc ccaagacgga ggagggggtt tccctcccag agggagtgga    360

gatggaggaa ggactccatg ttttcgttgg ccctgaaatg ccttatcagt ctgtccacca    420

tcatcctttt gggcttgatc atcgcctacc acacacgtga agtccagctc ttcgtgatcg    480

acaatggcgc ggatgactgg cggatagcca tgacctacga gcgcatcctg tacatcagcc    540

tggagatgct ggtgtgcgcc atccacccca ttcctggcga gtacaagttc ttctggacgg    600

cacgcctggc cttctcctac acaccctccc gggcggaggc cgatgtggac atcatcctgt    660

ctatccccat gttcctgcgc ctgtacctga tcgcccgagt catgctgctg cacagcaagc    720

tcttcaccga tgcctcgtcc cgcagcatcg gggccctcaa caagatcaac ttcaacaccc    780

gctttgtcat gaagacgctc atgaccatct gccctggcac tgtgctgctc gtgttcagca    840

tctctctgtg gatcattgct gcctggaccg tccgtgtctg tgaaaggtac catgaccagc    900

aggacgtaac tagtaacttt ctgggtgcca tgtggctcat ctccatcaca ttcctttcca    960

ttggttatgg ggacatggtg ccccacacat actgtgggaa aggtgtctgt ctcctcactg   1020

gcatcatggg tgcaggctgc actgcccttg tggtggccgt ggtggcccga aagctggaac   1080

tcaccaaagc ggagaagcac gttcataact tcatgatgga cactcagctc accaagcgga   1140

tcaagaatgc tgcagccaat gtccttcggg aaacatggtt aatctataaa cacacaaagc   1200

tgctaaagaa gattgaccat gccaaagtga ggaaacacca gaggaagttc ctccaagcta   1260

tccaccagtt gaggagcgtc aagatggaac agaggaagct gagtgaccaa gccaacactc   1320

tggtggacct ttccaagatg cagaatgtca tgtatgactt aatcacagaa ctcaatgacc   1380

ggagcgaaga cctggagaag cagattggca gcctggagtc gaagctggag catctcaccg   1440

ccagcttcaa ctccctgccg ctgctcatcg ccgacaccct gcgccagcag cagcagcagc   1500

tcctgtctgc catcatcgag gcccggggtg tcagcgtggc agtgggcacc acccacaccc   1560

caatctccga tagccccatt ggggtcagct ccacctcctt cccgaccccg tacacaagtt   1620

caagcagttg ctaaataaat ctccccactc cagaagcatt acccataggt cttaagatgc   1680

aaatcaactc tctcctggtc gctttgccat caagaaacat tcagaccagg gaacggaaag   1740

aagagagacc gagctaatta actaactcat gttcattcag cgtgcttggt ccgacatgcc   1800

ttgaaaccag aaatctaatc tctgtttagg tgcctctact tgggagcggg aagaggagat   1860

gacaggaagc gacgcctctg gcagggccct tgctgcagag ttggtggaga acagaaatcc   1920

acgctcaatc tcaggtcttc acgcgggggg tgggggtcag atgcactgaa gtagccaaca   1980

gcgaagccag tccagaagag gggtccgctg ggagggaggg ttgtgtcagg cttgggggat   2040

gggctcttcg ccatgggggt ctttgaacac acctctctcc tttccttttg tctacggaag   2100

cctctgggtg acaaaagtaa aagagagctg cccacaactt gccaaaacag atatactcga   2160

atcagactga aaaaaaaaaa aaaagacaca gacaaataaa aagccagatt ttccactcga   2220

tattaatacc cacataaacc tgtgtgtttg caaacgtgta catgtacaca catacacatc   2280

ccacgttcgc ttcaggtcct ttcttatttg agcttaatcc aaataaaaag ggacttgaca   2340

ccttaccctg catacaatag gcacccctta catgtgtttt gagttggtct gaatctgaac   2400

atggggtgct ttcagttcag gtagttagct agttctggcc acattctgag tttcactgaa   2460

gatgtggatc ccttcagaca taatgcacat tgctttgtcc tggatatgca ccttgcttga   2520

tttgaaatgg atgccaagcc aaaattgttg gcattcagga gggataagca ggcttctaaa   2580

aataacagca tctgcagagt tttcttcttc catccaaaca agttgtgttt cgatggtcca   2640

catgaccagg tgtatgtctg taagtgtgga gggagaggac aagaaattgt gcatgtgtgt   2700

gcagacatgc acaaacagga gcaatccaat aacaccttag tgaatagaaa tatggttggg   2760

gatttgctga gctgtattta tccagcaaca ggtttccagc cccagatgtt agtagtgcaa   2820

aagggccaag tgcctcaatt gtgagcctct gagctaggag gagaagtgat gaagagtggc   2880

ctatgtggtc ccttctacct gaccttaagt catctcaaaa tgaaatattg tgagaatgaa   2940

gggaaccctt agggaacctt gtgggtaagg taagtggaca tggatttgtc agtagcctgt   3000

tcctactgtg ccatgttaat cttggtgcga aaaactattc caatacatct caaactccaa   3060

gagacttcag aaacatcaag atttagtgta atgagc                             3096


<210>  1267
<211>  418
<212>  PRT
<213>  Homo sapiens

<400>  1267


Met Phe Ser Leu Ala Leu Lys Cys Leu Ile Ser Leu Ser Thr Ile Ile 
1               5                   10                  15      


Leu Leu Gly Leu Ile Ile Ala Tyr His Thr Arg Glu Val Gln Leu Phe 
            20                  25                  30          


Val Ile Asp Asn Gly Ala Asp Asp Trp Arg Ile Ala Met Thr Tyr Glu 
        35                  40                  45              


Arg Ile Leu Tyr Ile Ser Leu Glu Met Leu Val Cys Ala Ile His Pro 
    50                  55                  60                  


Ile Pro Gly Glu Tyr Lys Phe Phe Trp Thr Ala Arg Leu Ala Phe Ser 
65                  70                  75                  80  


Tyr Thr Pro Ser Arg Ala Glu Ala Asp Val Asp Ile Ile Leu Ser Ile 
                85                  90                  95      


Pro Met Phe Leu Arg Leu Tyr Leu Ile Ala Arg Val Met Leu Leu His 
            100                 105                 110         


Ser Lys Leu Phe Thr Asp Ala Ser Ser Arg Ser Ile Gly Ala Leu Asn 
        115                 120                 125             


Lys Ile Asn Phe Asn Thr Arg Phe Val Met Lys Thr Leu Met Thr Ile 
    130                 135                 140                 


Cys Pro Gly Thr Val Leu Leu Val Phe Ser Ile Ser Leu Trp Ile Ile 
145                 150                 155                 160 


Ala Ala Trp Thr Val Arg Val Cys Glu Arg Tyr His Asp Gln Gln Asp 
                165                 170                 175     


Val Thr Ser Asn Phe Leu Gly Ala Met Trp Leu Ile Ser Ile Thr Phe 
            180                 185                 190         


Leu Ser Ile Gly Tyr Gly Asp Met Val Pro His Thr Tyr Cys Gly Lys 
        195                 200                 205             


Gly Val Cys Leu Leu Thr Gly Ile Met Gly Ala Gly Cys Thr Ala Leu 
    210                 215                 220                 


Val Val Ala Val Val Ala Arg Lys Leu Glu Leu Thr Lys Ala Glu Lys 
225                 230                 235                 240 


His Val His Asn Phe Met Met Asp Thr Gln Leu Thr Lys Arg Ile Lys 
                245                 250                 255     


Asn Ala Ala Ala Asn Val Leu Arg Glu Thr Trp Leu Ile Tyr Lys His 
            260                 265                 270         


Thr Lys Leu Leu Lys Lys Ile Asp His Ala Lys Val Arg Lys His Gln 
        275                 280                 285             


Arg Lys Phe Leu Gln Ala Ile His Gln Leu Arg Ser Val Lys Met Glu 
    290                 295                 300                 


Gln Arg Lys Leu Ser Asp Gln Ala Asn Thr Leu Val Asp Leu Ser Lys 
305                 310                 315                 320 


Met Gln Asn Val Met Tyr Asp Leu Ile Thr Glu Leu Asn Asp Arg Ser 
                325                 330                 335     


Glu Asp Leu Glu Lys Gln Ile Gly Ser Leu Glu Ser Lys Leu Glu His 
            340                 345                 350         


Leu Thr Ala Ser Phe Asn Ser Leu Pro Leu Leu Ile Ala Asp Thr Leu 
        355                 360                 365             


Arg Gln Gln Gln Gln Gln Leu Leu Ser Ala Ile Ile Glu Ala Arg Gly 
    370                 375                 380                 


Val Ser Val Ala Val Gly Thr Thr His Thr Pro Ile Ser Asp Ser Pro 
385                 390                 395                 400 


Ile Gly Val Ser Ser Thr Ser Phe Pro Thr Pro Tyr Thr Ser Ser Ser 
                405                 410                 415     


Ser Cys 
        

<210>  1268
<211>  1660
<212>  DNA
<213>  Homo sapiens

<400>  1268
gaggactcag aataaacctg ctgctgcttc gtaaacatct cctgataaaa atggctacag     60

gtgttacctg ggcagagcag ctgggcgccg ccttggaatc agctggggga gcacctctcc    120

ttgggacggg atgacagggc ttcccaggcg gtccccacaa gcccgcgccc cagctcagcc    180

ccagttctcc cctcccacct caactcctcc ttgggataaa taaagatgag tgtgtgtgtg    240

agtgcgcgcc cggatggaga acagcaggca ctggctttag cggggagctg gccccactgc    300

tccagcctct cagtccagcc ccaagacgga ggagggggtt tccctcccag agggagtgga    360

gatggaggaa ggactccatg ttttcgttgg ccctgaaatg ccttatcagt ctgtccacca    420

tcatcctttt gggcttgatc atcgcctacc acacacgtga agtccagctc ttcgtgatcg    480

acaatggcgc ggatgactgg cggatagcca tgacctacga gcgcatcctg tacatcagcc    540

tggagatgct ggtgtgcgcc atccacccca ttcctggcga gtacaagttc ttctggacgg    600

cacgcctggc cttctcctac acaccctccc gggcggaggc cgatgtggac atcatcctgt    660

ctatccccat gttcctgcgc ctgtacctga tcgcccgagt catgctgctg cacagcaagc    720

tcttcaccga tgcctcgtcc cgcagcatcg gggccctcaa caagatcaac ttcaacaccc    780

gctttgtcat gaagacgctc atgaccatct gccctggcac tgtgctgctc gtgttcagca    840

tctctctgtg gatcattgct gcctggaccg tccgtgtctg tgaaaggtac catgaccagc    900

aggacgtaac tagtaacttt ctgggtgcca tgtggctcat ctccatcaca ttcctttcca    960

ttggttatgg ggacatggtg ccccacacat actgtgggaa aggtgtctgt ctcctcactg   1020

gcatcatggg tgcaggctgc actgcccttg tggtggccgt ggtggcccga aagctggaac   1080

tcaccaaagc ggagaagcac gttcataact tcatgatgga cactcagctc accaagcgga   1140

tcaagaatgc tgcagccaat gtccttcggg aaacatggtt aatctataaa cacacaaagc   1200

tgctaaagaa gattgaccat gccaaagtga ggaaacacca gaggaagttc ctccaagcta   1260

tccaccagtt gaggagcgtc aagatggaac agaggaagct gagtgaccaa gccaacactc   1320

tggtggacct ttccaagatg cagaatgtca tgtatgactt aatcacagaa ctcaatgacc   1380

ggagcgaaga cctggagaag cagattggca gcctggagtc gaagctggag catctcaccg   1440

ccagcttcaa ctccctgccg ctgctcatcg ccgacaccct gcgccagcag cagcagcagc   1500

tcctgtctgc catcatcgag gcccggggtg tcagcgtggc agtgggcacc acccacaccc   1560

caatctccga tagccccatt ggggtcagct ccacctcctt cccgaccccg tacacaagtt   1620

caagcagttg ctaaataaat ctccccactc cagaagcatt                         1660


<210>  1269
<211>  418
<212>  PRT
<213>  Homo sapiens

<400>  1269


Met Phe Ser Leu Ala Leu Lys Cys Leu Ile Ser Leu Ser Thr Ile Ile 
1               5                   10                  15      


Leu Leu Gly Leu Ile Ile Ala Tyr His Thr Arg Glu Val Gln Leu Phe 
            20                  25                  30          


Val Ile Asp Asn Gly Ala Asp Asp Trp Arg Ile Ala Met Thr Tyr Glu 
        35                  40                  45              


Arg Ile Leu Tyr Ile Ser Leu Glu Met Leu Val Cys Ala Ile His Pro 
    50                  55                  60                  


Ile Pro Gly Glu Tyr Lys Phe Phe Trp Thr Ala Arg Leu Ala Phe Ser 
65                  70                  75                  80  


Tyr Thr Pro Ser Arg Ala Glu Ala Asp Val Asp Ile Ile Leu Ser Ile 
                85                  90                  95      


Pro Met Phe Leu Arg Leu Tyr Leu Ile Ala Arg Val Met Leu Leu His 
            100                 105                 110         


Ser Lys Leu Phe Thr Asp Ala Ser Ser Arg Ser Ile Gly Ala Leu Asn 
        115                 120                 125             


Lys Ile Asn Phe Asn Thr Arg Phe Val Met Lys Thr Leu Met Thr Ile 
    130                 135                 140                 


Cys Pro Gly Thr Val Leu Leu Val Phe Ser Ile Ser Leu Trp Ile Ile 
145                 150                 155                 160 


Ala Ala Trp Thr Val Arg Val Cys Glu Arg Tyr His Asp Gln Gln Asp 
                165                 170                 175     


Val Thr Ser Asn Phe Leu Gly Ala Met Trp Leu Ile Ser Ile Thr Phe 
            180                 185                 190         


Leu Ser Ile Gly Tyr Gly Asp Met Val Pro His Thr Tyr Cys Gly Lys 
        195                 200                 205             


Gly Val Cys Leu Leu Thr Gly Ile Met Gly Ala Gly Cys Thr Ala Leu 
    210                 215                 220                 


Val Val Ala Val Val Ala Arg Lys Leu Glu Leu Thr Lys Ala Glu Lys 
225                 230                 235                 240 


His Val His Asn Phe Met Met Asp Thr Gln Leu Thr Lys Arg Ile Lys 
                245                 250                 255     


Asn Ala Ala Ala Asn Val Leu Arg Glu Thr Trp Leu Ile Tyr Lys His 
            260                 265                 270         


Thr Lys Leu Leu Lys Lys Ile Asp His Ala Lys Val Arg Lys His Gln 
        275                 280                 285             


Arg Lys Phe Leu Gln Ala Ile His Gln Leu Arg Ser Val Lys Met Glu 
    290                 295                 300                 


Gln Arg Lys Leu Ser Asp Gln Ala Asn Thr Leu Val Asp Leu Ser Lys 
305                 310                 315                 320 


Met Gln Asn Val Met Tyr Asp Leu Ile Thr Glu Leu Asn Asp Arg Ser 
                325                 330                 335     


Glu Asp Leu Glu Lys Gln Ile Gly Ser Leu Glu Ser Lys Leu Glu His 
            340                 345                 350         


Leu Thr Ala Ser Phe Asn Ser Leu Pro Leu Leu Ile Ala Asp Thr Leu 
        355                 360                 365             


Arg Gln Gln Gln Gln Gln Leu Leu Ser Ala Ile Ile Glu Ala Arg Gly 
    370                 375                 380                 


Val Ser Val Ala Val Gly Thr Thr His Thr Pro Ile Ser Asp Ser Pro 
385                 390                 395                 400 


Ile Gly Val Ser Ser Thr Ser Phe Pro Thr Pro Tyr Thr Ser Ser Ser 
                405                 410                 415     


Ser Cys 
        

<210>  1270
<211>  634
<212>  DNA
<213>  Homo sapiens

<400>  1270
gaccactgaa aagttgttta atctctctgt gcctgggttt ctgcatttgt aaaacagagg     60

tgataataat aaattttagg cagagtttca agaaagtagt tgatacctct gtctctgaag    120

acagttgctg agcaaaaaga agggaaaaaa caagacttgg ggtggaggga tcagagagat    180

gggatcttgc tctgtcacct acactggagt gcagcagtac aatcatagct tactgtagcc    240

tcaaactctt gggctcaagt gatcctcctg cctgagcacc cccagtctct gcgattacag    300

gcatcaactt tcatcctttc aaatttctcc gaatttttca gcaacatagg ctcagggagg    360

agcccagtca aggcaaggag cagctggttg gagcatcatg cgcaacaaac tttaaagcat    420

cagaagaata aagctgaaga ctggacctca tgtacccctt cctgaagaga agaacccagg    480

ccgtgacccc tctcaccaaa ggaaatgatg ctttctaatg gaaagaatag cattcttagc    540

atcaacctct gtccactgag aagtttctta taccaacatg aaaattggta ccaggccaag    600

ccacccatcc caaagacagt cagtgatggc atct                                634


<210>  1271
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  1271


Met Met Leu Ser Asn Gly Lys Asn Ser Ile Leu Ser Ile Asn Leu Cys 
1               5                   10                  15      


Pro Leu Arg Ser Phe Leu Tyr Gln His Glu Asn Trp Tyr Gln Ala Lys 
            20                  25                  30          


Pro Pro Ile Pro Lys Thr Val Ser Asp Gly 
        35                  40          

<210>  1272
<211>  561
<212>  DNA
<213>  Homo sapiens

<400>  1272
actaggtaga gatgatggga tgagaaaaca caggaaaacc tgaaggtcat cttattcata     60

caaaaatcct cccatttggt cactgtccct tccaggccat ggctcttgtt ctgagtgagc    120

tcttcctttt atagatgaac aggctccagg ccagagtaag gatggtgtga caaagtgagg    180

agcaggagaa gatcagagaa atctgctaca aaaccaagga ggatcaaggc catcaagcta    240

cagatggtct tacaaatgga accccaaatg agctcaacta acaacttcta ccaaggaccc    300

ctggactgac ctgctggccc tttcactggc ctaaagagtt cccctctgga ggacactaca    360

attgtagggc cccttcttcg cccctatcca gcaggaagta gctacagtag tcatcgccca    420

attcccaaca gcagttgggg tgtcctgttt agagggggga ttgagaggtg aagccagctg    480

ggcttctggg tcgggtgggg acttggaaaa cttttctgtc tagctaaagg attgtaaatg    540

cacccatcag cactctgtaa a                                              561


<210>  1273
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  1273


Gln Ser Glu Glu Gln Glu Lys Ile Arg Glu Ile Cys Tyr Lys Thr Lys 
1               5                   10                  15      


Glu Asp Gln Gly His Gln Ala Thr Asp Gly Leu Thr Asn Gly Thr Pro 
            20                  25                  30          


Asn Glu Leu Asn 
        35      

<210>  1274
<211>  1619
<212>  DNA
<213>  Homo sapiens

<400>  1274
ggagctcccc tccctcgctc gctcctcgca agctcccgct cgctccctgc ccactcccgg     60

ggggacgttc cgtgccgcgg ccgccgcggc cgctgcttct ttcacacttt agttgggagc    120

tgcgcgccgc gctcagttac tggagagctg gccgcgcgcc gccgcctccc gcacgcttgc    180

acgcgggccc ggcttcgggg ttttgggttc ttactccaag cggcggggag gagggggagc    240

cccggacaca ctgtggggag gaggaggaag aagaggagga gggaggaaga aaaaagacga    300

ggaggacagg ggcggggggc gggaggcttg ccaccttcag cccccccgcg aacgcccaag    360

gtgcacacat cttgaccaac tcagcagcaa ggtggatttt ctttgtgttt aaagaaaaaa    420

aatgtccctg tgtctgtaga gatgatttgc agttcagccc ggctgaagct gaccgaatga    480

gactatgggc tgtgcctccg ccaagcatgt tgccactgtt caaaatgaag aggaagccca    540

gaaagggaaa aactaccaga acggagatgt gtttggcgat gagtatagga tcaaaccagt    600

ggaagaggtc aaatacatga aaaatggggc agaagaagag cagaaaatag cagccaggaa    660

ccaagaaaac ttggaaaaaa gtgccagctc aaatgtaaga cttaaaacta ataaagaggt    720

tccgggatta gttcatcaac ccagagcaaa catgcacatc tctgaaagcc aacaagaatt    780

cttcagaatg ctggatgaaa aaattgaaaa gggtcgggat tactgttcgg aagaagagga    840

tatcacatag caccaatttt accactcaaa ccaggagcta ctactgtgta aataggttac    900

accccagttg aaatctttgc aaaggtcggt tctattcagc gaacagcact atagcaaaag    960

aagatcgttc catattgtac gccccattaa attacagtgt ttcttaatga acttgcaaag   1020

gaatattgct aaaaacaaac aaaaaaaact gttatcgaac tttctttgtt gctgctagtt   1080

aaaacttgtt gcaacttttc acttctcttg tgtccaggta tgcagcaaaa ttctgcaatt   1140

tcaccttaaa gatactgttg gttttacaga tgctctccaa cctattttct ataagatgag   1200

gtagtggtga actcagataa caaacttctc ttctaaactg gttctgcttc taagacaagc   1260

atctcctgcc ctctctcctt cctccccatc tctcgcacgc agtctagaga tggactgagc   1320

cttgcttctc actggcagtg ttgagctttg gagatgggat ggttgctatg ccaagccttg   1380

tttctctgct cagaagaagt agagaagcta ttatcaatta aaagcatgct gtgatgtgac   1440

tcctggaagt gacgtaggag tgagtggcag gttgtttgat ttaataggta tcttaatcaa   1500

gaattaagct tgcaacattg gctttgctca gatgcagatg gaagtgtgat cacaatcatt   1560

ttgaatccct cttcctcact tttttttcta agaaaataaa cattttactg tttttatgg    1619


<210>  1275
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  1275


Met Gly Cys Ala Ser Ala Lys His Val Ala Thr Val Gln Asn Glu Glu 
1               5                   10                  15      


Glu Ala Gln Lys Gly Lys Asn Tyr Gln Asn Gly Asp Val Phe Gly Asp 
            20                  25                  30          


Glu Tyr Arg Ile Lys Pro Val Glu Glu Val Lys Tyr Met Lys Asn Gly 
        35                  40                  45              


Ala Glu Glu Glu Gln Lys Ile Ala Ala Arg Asn Gln Glu Asn Leu Glu 
    50                  55                  60                  


Lys Ser Ala Ser Ser Asn Val Arg Leu Lys Thr Asn Lys Glu Val Pro 
65                  70                  75                  80  


Gly Leu Val His Gln Pro Arg Ala Asn Met His Ile Ser Glu Ser Gln 
                85                  90                  95      


Gln Glu Phe Phe Arg Met Leu Asp Glu Lys Ile Glu Lys Gly Arg Asp 
            100                 105                 110         


Tyr Cys Ser Glu Glu Glu Asp Ile Thr 
        115                 120     

<210>  1276
<211>  3323
<212>  DNA
<213>  Homo sapiens

<400>  1276
ggagctcccc tccctcgctc gctcctcgca agctcccgct cgctccctgc ccactcccgg     60

ggggacgttc cgtgccgcgg ccgccgcggc cgctgcttct ttcacacttt agttgggagc    120

tgcgcgccgc gctcagttac tggagagctg gccgcgcgcc gccgcctccc gcacgcttgc    180

acgcgggccc ggcttcgggg ttttgggttc ttactccaag cggcggggag gagggggagc    240

cccggacaca ctgtggggag gaggaggaag aagaggagga gggaggaaga aaaaagacga    300

ggaggacagg ggcggggggc gggaggcttg ccaccttcag cccccccgcg aacgcccaag    360

gtgcacacat cttgaccaac tcagcagcaa ggtggatttt ctttgtgttt aaagaaaaaa    420

aatgtccctg tgtctgtaga gatgatttgc agttcagccc ggctgaagct gaccgaatga    480

gactatgggc tgtgcctccg ccaagcatgt tgccactgtt caaaatgaag aggaagccca    540

gaaagggaaa aactaccaga acggagatgt gtttggcgat gagtatagga tcaaaccagt    600

ggaagaggtc aaatacatga aaaatggggc agaagaagag cagaaaatag cagccaggaa    660

ccaagaaaac ttggaaaaaa gtgccagctc aaatgtaaga cttaaaacta ataaagaggt    720

tccgggatta gttcatcaac ccagagcaaa catgcacatc tctgaaagcc aacaagaatt    780

cttcagaatg ctggatgaaa aaattgaaaa gggtcgggat tactgttcgg aagaagagga    840

tatcacatag caccaatttt accactcaaa ccaggagcta ctactgtgta aataggttac    900

accccagttg aaatctttgc aaaggtcggt tctattcagc gaacagcact atagcaaaag    960

aagatcgttc catattgtac gccccattaa attacagtgt ttcttaatga acttgcaaag   1020

gaatattgct aaaaacaaac aaaaaaaact gttatcgaac tttctttgtt gctgctagtt   1080

aaaacttgtt gcaacttttc acttctcttg tgtccaggta tgcagcaaaa ttctgcaatt   1140

tcaccttaaa gatactgttg gttttacaga tgctctccaa cctattttct ataagatgag   1200

gtagtggtga actcagataa caaacttctc ttctaaactg gttctgcttc taagacaagc   1260

atctcctgcc ctctctcctt cctccccatc tctcgcacgc agtctagaga tggactgagc   1320

cttgcttctc actggcagtg ttgagctttg gagatgggat ggttgctatg ccaagccttg   1380

tttctctgct cagaagaagt agagaagcta ttatcaatta aaagcatgct gtgatgtgac   1440

tcctggaagt gacgtaggag tgagtggcag gttgtttgat ttaataggta tcttaatcaa   1500

gaattaagct tgcaacattg gctttgctca gatgcagatg gaagtgtgat cacaatcatt   1560

ttgaatccct cttcctcact tttttttcta agaaaataaa cattttactg tttttatgga   1620

tccttgtctt ctcccattca tccagctcag tgttttaaga tgatcctggg tgcagaagtt   1680

gagccctcct ttgcattgac actgataatt agcctatagg gctccctacc cttccattaa   1740

gaatctacca agcattagca aggctgaaag tggtctaaga ggtgagggga catcctatga   1800

ctttttagga aggcctgaaa ccaccttgtt acctttcatt ttgttagcaa ataaaccatc   1860

ctattttgta actctccccc ttcaaaatgc tacatgagcc ttgccacttc ctttttctct   1920

tacttccagc acactagaca tagcaaaagt gtttgcctac tcaaaaacat aatactttta   1980

tgctgatgat ggtatttgga gatgtgaaag ccaaaagccc ctggcagtgg tggggaatgt   2040

tgactgagtg ttcagcagag tttatttttc catactatat gaagagaatg atctcttctc   2100

aaagacagaa gtgatatttt taacaaatat tgtcacaagt aaatagcaat caaaaggaga   2160

aaataacttt tgtatttttt taatgtgttt gatagctttg acgagggttc tctttgttac   2220

tttcagggga gggcatccta ttaaatgcca cgccagcagt ccgggtctgg gtttgtccca   2280

caaaatcaca ggagcactgt atgttcctct cttttggagt tgtgactttg aagggcctca   2340

atattagcca cactgccgcc tgcagaaggt ggagagttaa gatgttctat gtcaatttgc   2400

tcttgccgaa aagatgagcc tcgattttaa aatctatcca catccaactg atggcaccat   2460

tgatgtgcaa ataatgagat tccctatctc cttttagacc tgggacggca aaagggaagg   2520

gaaggaaact tagcagagtg ctattgacta tagattcaca tattagcaac aaaatcccgt   2580

aattcttttg gccaacagca gctattttgg ggagcagctg tggctgttac ataaatagag   2640

atgcagccaa aattttaggc cttttatcct gcttctagca gaaaaatgca gggagagtca   2700

agtagtctag ggtttcaggt tgcctcccct catatggttt ttggccaagt gactaaaaca   2760

gttttccaca actgtaaaca aactgctaag ccccacctca aacttgttca ctggggactt   2820

tgcttaccgt tctgtgggtg accttttccg ggatttcttg ttcttatcaa gcaagaatta   2880

agcacatgct aaacgtcttc catttgactt ctctactcgg tgtctcagac agtgtcttcc   2940

cagaaaacca ccaccctcta cccaaagatg aaacatgctc atgtcatttt tctcatggtc   3000

acatttaaca gttttgacat gttatacttg cgcatagatc caagcgtttc ttgggaacct   3060

gacttttgag tgtttaataa agccggaagt ggtgttgccc tgaaccagca gattttcacc   3120

tgggttctgg ctccggtgtt taacactgga tacatctttg atgtgcgaaa gtgagttcat   3180

cttcagacac atttggtaca tccagaaata gatccaagaa atggggtggt tgagtgggtc   3240

cgcacgaaat gcttgattat gtcagcaaca cccaacactg tctgttttcc atttgttggt   3300

tttaatcata aaattgtcaa gtg                                           3323


<210>  1277
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  1277


Met Gly Cys Ala Ser Ala Lys His Val Ala Thr Val Gln Asn Glu Glu 
1               5                   10                  15      


Glu Ala Gln Lys Gly Lys Asn Tyr Gln Asn Gly Asp Val Phe Gly Asp 
            20                  25                  30          


Glu Tyr Arg Ile Lys Pro Val Glu Glu Val Lys Tyr Met Lys Asn Gly 
        35                  40                  45              


Ala Glu Glu Glu Gln Lys Ile Ala Ala Arg Asn Gln Glu Asn Leu Glu 
    50                  55                  60                  


Lys Ser Ala Ser Ser Asn Val Arg Leu Lys Thr Asn Lys Glu Val Pro 
65                  70                  75                  80  


Gly Leu Val His Gln Pro Arg Ala Asn Met His Ile Ser Glu Ser Gln 
                85                  90                  95      


Gln Glu Phe Phe Arg Met Leu Asp Glu Lys Ile Glu Lys Gly Arg Asp 
            100                 105                 110         


Tyr Cys Ser Glu Glu Glu Asp Ile Thr 
        115                 120     

<210>  1278
<211>  10321
<212>  DNA
<213>  Homo sapiens

<400>  1278
ggagctcccc tccctcgctc gctcctcgca agctcccgct cgctccctgc ccactcccgg     60

ggggacgttc cgtgccgcgg ccgccgcggc cgctgcttct ttcacacttt agttgggagc    120

tgcgcgccgc gctcagttac tggagagctg gccgcgcgcc gccgcctccc gcacgcttgc    180

acgcgggccc ggcttcgggg ttttgggttc ttactccaag cggcggggag gagggggagc    240

cccggacaca ctgtggggag gaggaggaag aagaggagga gggaggaaga aaaaagacga    300

ggaggacagg ggcggggggc gggaggcttg ccaccttcag cccccccgcg aacgcccaag    360

gtgcacacat cttgaccaac tcagcagcaa ggtggatttt ctttgtgttt aaagaaaaaa    420

aatgtccctg tgtctgtaga gatgatttgc agttcagccc ggctgaagct gaccgaatga    480

gactatgggc tgtgcctccg ccaagcatgt tgccactgtt caaaatgaag aggaagccca    540

gaaagggaaa aactaccaga acggagatgt gtttggcgat gagtatagga tcaaaccagt    600

ggaagaggtc aaatacatga aaaatggggc agaagaagag cagaaaatag cagccaggaa    660

ccaagaaaac ttggaaaaaa gtgccagctc aaatgtaaga cttaaaacta ataaagaggt    720

tccgggatta gttcatcaac ccagagcaaa catgcacatc tctgaaagcc aacaagaatt    780

cttcagaatg ctggatgaaa aaattgaaaa gggtcgggat tactgttcgg aagaagagga    840

tatcacatag caccaatttt accactcaaa ccaggagcta ctactgtgta aataggttac    900

accccagttg aaatctttgc aaaggtcggt tctattcagc gaacagcact atagcaaaag    960

aagatcgttc catattgtac gccccattaa attacagtgt ttcttaatga acttgcaaag   1020

gaatattgct aaaaacaaac aaaaaaaact gttatcgaac tttctttgtt gctgctagtt   1080

aaaacttgtt gcaacttttc acttctcttg tgtccaggta tgcagcaaaa ttctgcaatt   1140

tcaccttaaa gatactgttg gttttacaga tgctctccaa cctattttct ataagatgag   1200

gtagtggtga actcagataa caaacttctc ttctaaactg gttctgcttc taagacaagc   1260

atctcctgcc ctctctcctt cctccccatc tctcgcacgc agtctagaga tggactgagc   1320

cttgcttctc actggcagtg ttgagctttg gagatgggat ggttgctatg ccaagccttg   1380

tttctctgct cagaagaagt agagaagcta ttatcaatta aaagcatgct gtgatgtgac   1440

tcctggaagt gacgtaggag tgagtggcag gttgtttgat ttaataggta tcttaatcaa   1500

gaattaagct tgcaacattg gctttgctca gatgcagatg gaagtgtgat cacaatcatt   1560

ttgaatccct cttcctcact tttttttcta agaaaataaa cattttactg tttttatgga   1620

tccttgtctt ctcccattca tccagctcag tgttttaaga tgatcctggg tgcagaagtt   1680

gagccctcct ttgcattgac actgataatt agcctatagg gctccctacc cttccattaa   1740

gaatctacca agcattagca aggctgaaag tggtctaaga ggtgagggga catcctatga   1800

ctttttagga aggcctgaaa ccaccttgtt acctttcatt ttgttagcaa ataaaccatc   1860

ctattttgta actctccccc ttcaaaatgc tacatgagcc ttgccacttc ctttttctct   1920

tacttccagc acactagaca tagcaaaagt gtttgcctac tcaaaaacat aatactttta   1980

tgctgatgat ggtatttgga gatgtgaaag ccaaaagccc ctggcagtgg tggggaatgt   2040

tgactgagtg ttcagcagag tttatttttc catactatat gaagagaatg atctcttctc   2100

aaagacagaa gtgatatttt taacaaatat tgtcacaagt aaatagcaat caaaaggaga   2160

aaataacttt tgtatttttt taatgtgttt gatagctttg acgagggttc tctttgttac   2220

tttcagggga gggcatccta ttaaatgcca cgccagcagt ccgggtctgg gtttgtccca   2280

caaaatcaca ggagcactgt atgttcctct cttttggagt tgtgactttg aagggcctca   2340

atattagcca cactgccgcc tgcagaaggt ggagagttaa gatgttctat gtcaatttgc   2400

tcttgccgaa aagatgagcc tcgattttaa aatctatcca catccaactg atggcaccat   2460

tgatgtgcaa ataatgagat tccctatctc cttttagacc tgggacggca aaagggaagg   2520

gaaggaaact tagcagagtg ctattgacta tagattcaca tattagcaac aaaatcccgt   2580

aattcttttg gccaacagca gctattttgg ggagcagctg tggctgttac ataaatagag   2640

atgcagccaa aattttaggc cttttatcct gcttctagca gaaaaatgca gggagagtca   2700

agtagtctag ggtttcaggt tgcctcccct catatggttt ttggccaagt gactaaaaca   2760

gttttccaca actgtaaaca aactgctaag ccccacctca aacttgttca ctggggactt   2820

tgcttaccgt tctgtgggtg accttttccg ggatttcttg ttcttatcaa gcaagaatta   2880

agcacatgct aaacgtcttc catttgactt ctctactcgg tgtctcagac agtgtcttcc   2940

cagaaaacca ccaccctcta cccaaagatg aaacatgctc atgtcatttt tctcatggtc   3000

acatttaaca gttttgacat gttatacttg cgcatagatc caagcgtttc ttgggaacct   3060

gacttttgag tgtttaataa agccggaagt ggtgttgccc tgaaccagca gattttcacc   3120

tgggttctgg ctccggtgtt taacactgga tacatctttg atgtgcgaaa gtgagttcat   3180

cttcagacac atttggtaca tccagaaata gatccaagaa atggggtggt tgagtgggtc   3240

cgcacgaaat gcttgattat gtcagcaaca cccaacactg tctgttttcc atttgttggt   3300

tttaatcata aaattgtcaa gtgattcgtg tttgtacttt atttttttgt gccttctgaa   3360

aggatctaaa acaaaaatat tttgcctttt tttccccacg tgtatctgaa cattaagcag   3420

attggctcag acacaatgaa aaggataatc caatgtacgt gctggtgcac tctgctagtt   3480

gttatctctg tagggctcag gaagctggaa ggaggaaggg agggtaagtg gcctggtgag   3540

tggaggtaga aaaatgatga gaaatgaact gagagcatta agcagagagg gttgataggc   3600

tggccgtgtc cggggtgaaa ttggaaatcc agctgcctag tggccagtgg gtggggcaag   3660

actgtcaacg agatttacag ctggcttaca catgccttat gtcctctgag ttgtagagtt   3720

gtaaaagttc agcagtgtgt gcacagcttt cttttggttg gcagagattc aggatcatgg   3780

agtactgctc tcataattga agacgtgttt gttattggca gagaacctta aaaaaggcct   3840

ttacctcagc gatgcttcct agccccaggc ttgcagagaa cacagagtgg tgttgtggtc   3900

tatttaggga caaagaaggt ataaagtcca gagatgagaa aactgggtca gccctcagaa   3960

actgcagcag ccacgcacac agaagcctgc tggaagacag gtctctctcc gtccacagtg   4020

cccatcatct gagcctgggc tgggatgact caacttagca aagacggacc caggaggagt   4080

gctggttctt cagtctttgt actggcccca tcctctcctc actgtaatgt gaggaagcac   4140

ctctgtgtca gggctcacct gggcatccaa agcggccacg cccacaatcc gacagccccc   4200

aggagcaggt ccagggatga tgcagccccc ttcttggtcc catgtgatgt catcctgctt   4260

tgttatcttc ttataacttt atcctgctat aactttatcc tcttcccagc ctcatccctg   4320

tttttctgtt agggcaagac tcttccataa gcctgctaaa aaacagagat gatacctctt   4380

acaaacttta cctcatagcc tgtgaagcag gttggcatgt ggattacaag tcctgctttg   4440

acactgggca agaatttaag attgttctat ctctactagt catagaaaag aaacattgtt   4500

aaacatgttg agttttaaag gaagaaatat tttcaaattc ttaatccaag aaaatactga   4560

gttggaatct tagacttcgg gactctgaca cgttctttat gaaaggcaaa ataattggta   4620

tctaaagttc tctccttcct gcctccccta aagaaaaagg atattagatt gcacactata   4680

attttacata agatctgcct tccacacttc cctgctggaa ggcattctca gagctttatg   4740

tcttcgtacc tctcagagat tggacttttt cttgtttaaa accccaacca aaaaaaataa   4800

taaggcatga ttggtgggga gggaatgtgt atttaggggc ataataaaaa ggtggctcga   4860

agcaggaact ttggcctcat ggtgtcatgg gtggatgcct ggactccagt gtgcctgtga   4920

ggggctgggt taggcagtcg gctgtcacac tcacatgtgc ctgcaataaa ccttttggaa   4980

tttcatgaac gaggtctatg aattgccttt tgccaatgaa tggatgtatt tttccaaggg   5040

gggaatagta tccttgactt tggcagtcac ctttttgtat gtctctagaa aggggtcaaa   5100

aaactatggt aaagatgagg cttatgagtg aatacctctg ggacaaacct taggactcac   5160

aagctatgcc atgtttttca ggagactctt gtaccttatc tggaatctaa tcttgggaga   5220

agaggaaaaa ggagctaata tttgtcattt atactcactc tgtgccagat actgtgctag   5280

gcattttata attgttttgt gtcatcctca tgataatcct gtgaagtaga tctattaccc   5340

ccgtgttcta aataatagat cttaagtgtg gaatgcatct atccaacata aatgcccatg   5400

ttgaaagaag gaaagatgtc attcaagtat ttttcaaatt ctttttatta tgactatgcc   5460

cttcgcaaca ctgtgaaaac aacccctggg ggcatctgcc ttccagaatc tctctctggc   5520

ttctcaccag cttggtttcc tcatggggag tgttttattt ggcctcccct atctgagctg   5580

cacacacacc aggggaggcc actggctaac agtaggactt cagtgccctg aggaaaaggc   5640

tttgggaatt taggcacacg tttctctcct tggaatcctt ctagcatctg gaaaaggaac   5700

ctggtatttc tgcagttaga taccagatgc aaccagaaca ggctttcgag tgctgtgatt   5760

tctttcctgg gttcccaagt cttgttgttt catcacaaac tgtatctttt taaggttaaa   5820

agtcttgacc ttcatggggg tctgggacaa tccgatctcc aagcatggag gaaaggcaat   5880

gcctggacca ctgacttgca ttgaaatcct ttcttgtggg ctagggtttg atgtctcttt   5940

ttcatctttg gactggggat ctgcatcttc caggtccatt taagcactga aactagatgc   6000

aaatctcttt cgagacctta catgttttag atagtcatgt aatgacttgg atagacattt   6060

aaataacttg ttccaaggtc ggaagagccc aagaactcct cagagttcct cttcttgctt   6120

cttgaatcac atcctctaaa gatgactcat gtctccatag caactgttaa aggtgctgcc   6180

tagacgggac ccgctcccac ctttacttac tttgctcgaa ggaaccaaaa caatgtcctt   6240

gtgtaaaggg gctgtcatat ccagttttcc tttgaaatct ggcccccaag atcctgcttc   6300

tttctaacct ggcagctgtc atgtcccttc aagatgatgt gggaaatggc ccttacaact   6360

tgggaaccac agaaattgct gtatttcggg aagattcacc tctaaactga aggcttcatt   6420

ctgatagtgt ctgccctctc taccctgatt tcgcccttct ttgcttccat ttttagccca   6480

aggctttgaa tttgattgag taagacttag aggcagtata aagaacacca taaacttagg   6540

cagaggtccc ttagggtctc tagagttgaa aataattcta cagccttagg gggacctctt   6600

ggcattgact ctaaagggag agaatagccc ctgtgtcctg gcatttcagt ctagaccttc   6660

aaggactgtt ctctcttgac aggcaagcaa gcaaagaaag ttttgcaata gatttcaagc   6720

cagtttttcc attcaaacca agatgcaaat tcataaaatt actcttttcc tggaatagat   6780

ccaggcagct gccttattag aactttagat tcggatctat tttcttaaca cacatacaca   6840

tacacgcgca tacatacata tacagagaga tacgtggaga aaggaaattt actctatcat   6900

tgcaatactt caagaaagag ctgtattttg cctttctgta atctccaaga tagtgtctag   6960

gaaagtaata gtataactat agggataccg aaacaggaaa aaccagccat cactcttgag   7020

aaagtttgag ttcgactcac atgggagaat cgaggtctgc tactcgtctt gctttgtgcc   7080

ccatctgtgc ctggatgccc tactacatct gcttgactcg tctgggctgc tagccggggt   7140

gttgtggctg acatcctttc ctggccttac acacataata gacacatccc taacggcgtg   7200

tgcctggtcc agccacatac agccaccaca tgtgtcacac actgtccccc tcatccatgt   7260

ggacttgact ggcatttcag cagctccact gggatgctct aaccccagtg tgtggagttg   7320

gggtcccttc atctaggttg acccaggtat agcattttta gcattgcctt tccagtcttg   7380

atgattcatt cattgaactc atttatttct ggagcccctg gtacactcca ggcactgcgc   7440

taattgccag caaagcacaa ctgaactaaa tccaccttca aggaacctag ccataacgag   7500

ggaggcagca tggaagtacc ctacagggga aagtcctgag tgctgtggga gcatctcacc   7560

gtggcagcca gcccagtttt ggcaatcagg ggcttcctga aagaggtgac atcaaagccc   7620

ggatgtgtca gaggactgag ggagagtgtt actaaaggac tttcaggctg agaggatagc   7680

acaggactca gcccaaagga gggccagtgt ggactgtcca gggccagcct gcagtacaga   7740

ggctggagct tggacttgta gagggagaga gaagagcaag ggacgtggac ggggcagtga   7800

gccaggctag ccacagaggg ttcccggggc tttgctgggg attcagggag cataaataag   7860

agctttaggt ggtgctgtgt cctctgcagc ccactgctga ggtcctccag acaggtaagg   7920

tgtggtcaca atcagggccg gggtttccct gctcactgcg gcagtgcagg ggtgcttgct   7980

gagatgattc atcccagggt gtcctctgtc ccttacccag ccccaactcc tcttcctctg   8040

ccaaaagcta tttgaattca aggactttaa cctgggccgg atctggtttg gagacaaagg   8100

ggacagctct gggtcagcat gaccttcttt agagccacta aggcgaaaaa taccgtttgg   8160

gaccaggctg gcctagaccc agggatgaga atgcacccta aaataaatat acgggaagca   8220

gcagagggct tccctgtcta gtgtgtgatc ctaactaaag gcagctctct tggacagcct   8280

tcccctggat taggtcacat acacctggtg gccaagcctc tgctgggtcc caaatacaca   8340

cccgagtcct gccaaagaaa ggagattttt aaaaagcaca gacaaattgt atgcaagtgg   8400

aaaataccca taggcctaga cagctgtgga gggaagacct cgtgggtacc tggaggctgc   8460

cagagctggg agctctgcag gtatgagtca gggaaggctc agagacaagc agaatctctc   8520

tatggagaca acttgcagtg ccttttaggt tttccaaata acctcggagt tcagagcatt   8580

gggttttttt ctcccctccc cacccccaga aaaataatta gaaaaatgtt taggagaaag   8640

gaaaagaatt agatgcatca gaataccagc tataagccaa cactgtttcc agaaactcaa   8700

gaaaaagctc aaacagaaga cagttcccct gagaggctgg aggcgttggt gctgaaggca   8760

attttcctag ctaaggggca ctgggccttg ctgcaccttg gggctgacct tttttgcaaa   8820

acacccaccc ctgccctcct ggcatactca acagcaacgc cagctttctg gacccttgga   8880

aagatgttag ctcaaacacc cactttttcc agatcttcct cttgctcttc actgaggaat   8940

ttgtaattct gaggctagcg atgcccactc ggatattccg caggcccagg tgtttagatt   9000

agaatttgtc cagcggtaat cctgatgctg gaaaccaaca aacatttggc ctcatattca   9060

cccatttaaa aactagagcc cctggcaggt ccccttaggg ccatgtgttc atggaatata   9120

agccaagttt gccttaggct tgttcatgga atataagcca agtttacctc tccccatttt   9180

ctgccctggc ccacttccca ctcacctcca cctcattgcc aggaagggat caaaatgcct   9240

ccatgccagt tgttaatggc tacatatttg cccttcccaa gggtatttgc attttattta   9300

ggaacatggc cttatattca aggaaaatct agcatcaaga ttacgaggca tcacctctca   9360

atcaggtctg ggaggtatct tggggcattg ctcttctgaa cacctgcaga ggcttcctca   9420

ggtgagtgtg ggagcccgga agggtggcct ccctaaccac tctgcctgca catgaattct   9480

ccaaagcagt gggcccccat ctgtttcaat tacacatgcc tgtcagcaaa aacttcgtga   9540

gatgcactct ctctgtgtgt ttattaattt atttaaagca tatatccctt tacttttgta   9600

ctactatatt aggcacatta taaaaagtat acagcataga aactttaaat gaataagaca   9660

caaaatatta taaacagagg ttctggcatt ttctctctga actcctgagg gggaccttgg   9720

gcacctcctg gtatgtgcac accccacttt gaacaccctt gctttagtgc aaatcagcac   9780

gcctaaatag catcccaaac cactgtgcga catttggcct gcagaataag aaagtcctaa   9840

ggcagaatcc ccaggaactt caaatctggg agatgaggaa agaaaactca ctcacaaaca   9900

acataaatgt aaataattca aaaccctaaa ggagagctgt ccctagacag tagtggctac   9960

aggtgctaag caaaagtcag gtacactgga cagagccatg cgattgattg ttcatcttcc  10020

ctctctgggt ctccagaaaa ggacactggc aatatcccca gctctctcct gattggaatt  10080

ctttgaaccc tcgaagtgct ccagcagtac taccccccac gtagcagtgg gcccatgtcg  10140

cttgaatatt atttttgatt tgaccaccaa gatgtaatga tgattctatt ccattttgaa  10200

aagggtctga gaaagtgtac aggtctaatt atatatacat atttatacat gtgtattttt  10260

gtttattgtt acattttgac attggacttt ctattaaata atttttaaga gttggcctgg  10320

c                                                                  10321


<210>  1279
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  1279


Met Gly Cys Ala Ser Ala Lys His Val Ala Thr Val Gln Asn Glu Glu 
1               5                   10                  15      


Glu Ala Gln Lys Gly Lys Asn Tyr Gln Asn Gly Asp Val Phe Gly Asp 
            20                  25                  30          


Glu Tyr Arg Ile Lys Pro Val Glu Glu Val Lys Tyr Met Lys Asn Gly 
        35                  40                  45              


Ala Glu Glu Glu Gln Lys Ile Ala Ala Arg Asn Gln Glu Asn Leu Glu 
    50                  55                  60                  


Lys Ser Ala Ser Ser Asn Val Arg Leu Lys Thr Asn Lys Glu Val Pro 
65                  70                  75                  80  


Gly Leu Val His Gln Pro Arg Ala Asn Met His Ile Ser Glu Ser Gln 
                85                  90                  95      


Gln Glu Phe Phe Arg Met Leu Asp Glu Lys Ile Glu Lys Gly Arg Asp 
            100                 105                 110         


Tyr Cys Ser Glu Glu Glu Asp Ile Thr 
        115                 120     

<210>  1280
<211>  706
<212>  DNA
<213>  Homo sapiens

<400>  1280
atttgcaaat caaacataaa gcctgaaagg aaacattact tttcattaaa tagacggcca     60

gccgaatgaa cagagaagaa gtccggacag cttttcaatg tgatggattc tgtggcaagg    120

attacatcat tggggggttt tatatttcta taattttaga ttagttattt tagttccctt    180

acccccattt ttaaatattc ctgtcagcta aaacaaggat tttcttagga aatgatgaag    240

ccaggtttaa tttctactta gtgagaagac tgcattacca ccccactgtt aaggtgcagg    300

tattgtcagt agggcaagga tgggttttct tttgtaagga atgcatttga agggatagat    360

tacagactca gggtaatgtg aacctgtttc catgcttggg aatgtcctcc caggtgatgg    420

acatccctta ggggaagcct caggtaggat aagcaaagcc taggttctta tttgcttgtt    480

tcttaaagaa acacaataat aaagacaaaa atggtgtatg gatcaaacag atgaaaccag    540

aagagtgtta atatccagaa atgtattctc taaggctctg cctaattata ttaaaagtaa    600

tttgcaaatc tggccctgag ttttctgtaa ccatatgaaa acaagaaaca ctatcagtca    660

caagattctg ttatagcctg ggcaacatag tgagacccca tctctg                   706


<210>  1281
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  1281


Met Asn Arg Glu Glu Val Arg Thr Ala Phe Gln Cys Asp Gly Phe Cys 
1               5                   10                  15      


Gly Lys Asp Tyr Ile Ile Gly Gly Phe Tyr Ile Ser Ile Ile Leu Asp 
            20                  25                  30          

<210>  1282
<211>  1033
<212>  DNA
<213>  Homo sapiens

<400>  1282
actggcaacc accattctac tttctgtctc catgaatttg actactccag gctgctgtgc     60

attttagaga agttcttatg tgatactgaa aaaagtgcca gctcaaatgt aagacttaaa    120

actaataaag aggttccggg attagttcat caacccagag caaacatgca catctctgaa    180

agccaacaag aattcttcag aatgctggat gaaaaaattg aaaagggtcg ggattactgt    240

tcggaagaag aggatatcac atagcaccaa ttttaccact caaaccagga gctactactg    300

tgtaaatagg ttacacccca gttgaaatct ttgcaaaggt cggttctatt cagcgaacag    360

cactatagca aaagaagatc gttccatatt gtacgcccca ttaaattaca gtgtttctta    420

atgaacttgc aaaggaatat tgctaaaaac aaacaaaaaa aactgttatc gaactttctt    480

tgttgctgct agttaaaact tgttgcaact tttcacttct cttgtgtcca ggtatgcagc    540

aaaattctgc aatttcacct taaagatact gttggtttta cagatgctct ccaacctatt    600

ttctataaga tgaggtagtg gtgaactcag ataacaaact tctcttctaa actggttctg    660

cttctaagac aagcatctcc tgccctctct ccttcctccc catctctcgc acgcagtcta    720

gagatggact gagccttgct tctcactggc agtgttgagc tttggagatg ggatggttgc    780

tatgccaagc cttgtttctc tgctcagaag aagtagagaa gctattatca attaaaagca    840

tgctgtgatg tgactcctgg aagtgacgta ggagtgagtg gcaggttgtt tgatttaata    900

ggtatcttaa tcaagaatta agcttgcaac attggctttg ctcagatgca gatggaagtg    960

tgatcacaat cattttgaat ccctcttcct cacttttttt tctaagaaaa taaacatttt   1020

actgttttta tgg                                                      1033


<210>  1283
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  1283


Met Lys Lys Leu Lys Arg Val Gly Ile Thr Val Arg Lys Lys Arg Ile 
1               5                   10                  15      


Ser His Ser Thr Asn Phe Thr Thr Gln Thr Arg Ser Tyr Tyr Cys Val 
            20                  25                  30          


Asn Arg Leu His Pro Ser 
        35              

<210>  1284
<211>  2737
<212>  DNA
<213>  Homo sapiens

<400>  1284
actggcaacc accattctac tttctgtctc catgaatttg actactccag gctgctgtgc     60

attttagaga agttcttatg tgatactgaa aaaagtgcca gctcaaatgt aagacttaaa    120

actaataaag aggttccggg attagttcat caacccagag caaacatgca catctctgaa    180

agccaacaag aattcttcag aatgctggat gaaaaaattg aaaagggtcg ggattactgt    240

tcggaagaag aggatatcac atagcaccaa ttttaccact caaaccagga gctactactg    300

tgtaaatagg ttacacccca gttgaaatct ttgcaaaggt cggttctatt cagcgaacag    360

cactatagca aaagaagatc gttccatatt gtacgcccca ttaaattaca gtgtttctta    420

atgaacttgc aaaggaatat tgctaaaaac aaacaaaaaa aactgttatc gaactttctt    480

tgttgctgct agttaaaact tgttgcaact tttcacttct cttgtgtcca ggtatgcagc    540

aaaattctgc aatttcacct taaagatact gttggtttta cagatgctct ccaacctatt    600

ttctataaga tgaggtagtg gtgaactcag ataacaaact tctcttctaa actggttctg    660

cttctaagac aagcatctcc tgccctctct ccttcctccc catctctcgc acgcagtcta    720

gagatggact gagccttgct tctcactggc agtgttgagc tttggagatg ggatggttgc    780

tatgccaagc cttgtttctc tgctcagaag aagtagagaa gctattatca attaaaagca    840

tgctgtgatg tgactcctgg aagtgacgta ggagtgagtg gcaggttgtt tgatttaata    900

ggtatcttaa tcaagaatta agcttgcaac attggctttg ctcagatgca gatggaagtg    960

tgatcacaat cattttgaat ccctcttcct cacttttttt tctaagaaaa taaacatttt   1020

actgttttta tggatccttg tcttctccca ttcatccagc tcagtgtttt aagatgatcc   1080

tgggtgcaga agttgagccc tcctttgcat tgacactgat aattagccta tagggctccc   1140

tacccttcca ttaagaatct accaagcatt agcaaggctg aaagtggtct aagaggtgag   1200

gggacatcct atgacttttt aggaaggcct gaaaccacct tgttaccttt cattttgtta   1260

gcaaataaac catcctattt tgtaactctc ccccttcaaa atgctacatg agccttgcca   1320

cttccttttt ctcttacttc cagcacacta gacatagcaa aagtgtttgc ctactcaaaa   1380

acataatact tttatgctga tgatggtatt tggagatgtg aaagccaaaa gcccctggca   1440

gtggtgggga atgttgactg agtgttcagc agagtttatt tttccatact atatgaagag   1500

aatgatctct tctcaaagac agaagtgata tttttaacaa atattgtcac aagtaaatag   1560

caatcaaaag gagaaaataa cttttgtatt tttttaatgt gtttgatagc tttgacgagg   1620

gttctctttg ttactttcag gggagggcat cctattaaat gccacgccag cagtccgggt   1680

ctgggtttgt cccacaaaat cacaggagca ctgtatgttc ctctcttttg gagttgtgac   1740

tttgaagggc ctcaatatta gccacactgc cgcctgcaga aggtggagag ttaagatgtt   1800

ctatgtcaat ttgctcttgc cgaaaagatg agcctcgatt ttaaaatcta tccacatcca   1860

actgatggca ccattgatgt gcaaataatg agattcccta tctcctttta gacctgggac   1920

ggcaaaaggg aagggaagga aacttagcag agtgctattg actatagatt cacatattag   1980

caacaaaatc ccgtaattct tttggccaac agcagctatt ttggggagca gctgtggctg   2040

ttacataaat agagatgcag ccaaaatttt aggcctttta tcctgcttct agcagaaaaa   2100

tgcagggaga gtcaagtagt ctagggtttc aggttgcctc ccctcatatg gtttttggcc   2160

aagtgactaa aacagttttc cacaactgta aacaaactgc taagccccac ctcaaacttg   2220

ttcactgggg actttgctta ccgttctgtg ggtgaccttt tccgggattt cttgttctta   2280

tcaagcaaga attaagcaca tgctaaacgt cttccatttg acttctctac tcggtgtctc   2340

agacagtgtc ttcccagaaa accaccaccc tctacccaaa gatgaaacat gctcatgtca   2400

tttttctcat ggtcacattt aacagttttg acatgttata cttgcgcata gatccaagcg   2460

tttcttggga acctgacttt tgagtgttta ataaagccgg aagtggtgtt gccctgaacc   2520

agcagatttt cacctgggtt ctggctccgg tgtttaacac tggatacatc tttgatgtgc   2580

gaaagtgagt tcatcttcag acacatttgg tacatccaga aatagatcca agaaatgggg   2640

tggttgagtg ggtccgcacg aaatgcttga ttatgtcagc aacacccaac actgtctgtt   2700

ttccatttgt tggttttaat cataaaattg tcaagtg                            2737


<210>  1285
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  1285


Met Lys Lys Leu Lys Arg Val Gly Ile Thr Val Arg Lys Lys Arg Ile 
1               5                   10                  15      


Ser His Ser Thr Asn Phe Thr Thr Gln Thr Arg Ser Tyr Tyr Cys Val 
            20                  25                  30          


Asn Arg Leu His Pro Ser 
        35              

<210>  1286
<211>  7395
<212>  DNA
<213>  Homo sapiens

<400>  1286
actggcaacc accattctac tttctgtctc catgaatttg actactccag gctgctgtgc     60

attttagaga agttcttatg tgatactgaa aaaagtgcca gctcaaatgt aagacttaaa    120

actaataaag aggttccggg attagttcat caacccagag caaacatgca catctctgaa    180

agccaacaag aattcttcag aatgctggat gaaaaaattg aaaagggtcg ggattactgt    240

tcggaagaag aggatatcac atagcaccaa ttttaccact caaaccagga gctactactg    300

tgtaaatagg ttacacccca gttgaaatct ttgcaaaggt cggttctatt cagcgaacag    360

cactatagca aaagaagatc gttccatatt gtacgcccca ttaaattaca gtgtttctta    420

atgaacttgc aaaggaatat tgctaaaaac aaacaaaaaa aactgttatc gaactttctt    480

tgttgctgct agttaaaact tgttgcaact tttcacttct cttgtgtcca ggtatgcagc    540

aaaattctgc aatttcacct taaagatact gttggtttta cagatgctct ccaacctatt    600

ttctataaga tgaggtagtg gtgaactcag ataacaaact tctcttctaa actggttctg    660

cttctaagac aagcatctcc tgccctctct ccttcctccc catctctcgc acgcagtcta    720

gagatggact gagccttgct tctcactggc agtgttgagc tttggagatg ggatggttgc    780

tatgccaagc cttgtttctc tgctcagaag aagtagagaa gctattatca attaaaagca    840

tgctgtgatg tgactcctgg aagtgacgta ggagtgagtg gcaggttgtt tgatttaata    900

ggtatcttaa tcaagaatta agcttgcaac attggctttg ctcagatgca gatggaagtg    960

tgatcacaat cattttgaat ccctcttcct cacttttttt tctaagaaaa taaacatttt   1020

actgttttta tggatccttg tcttctccca ttcatccagc tcagtgtttt aagatgatcc   1080

tgggtgcaga agttgagccc tcctttgcat tgacactgat aattagccta tagggctccc   1140

tacccttcca ttaagaatct accaagcatt agcaaggctg aaagtggtct aagaggtgag   1200

gggacatcct atgacttttt aggaaggcct gaaaccacct tgttaccttt cattttgtta   1260

gcaaataaac catcctattt tgtaactctc ccccttcaaa atgctacatg agccttgcca   1320

cttccttttt ctcttacttc cagcacacta gacatagcaa aagtgtttgc ctactcaaaa   1380

acataatact tttatgctga tgatggtatt tggagatgtg aaagccaaaa gcccctggca   1440

gtggtgggga atgttgactg agtgttcagc agagtttatt tttccatact atatgaagag   1500

aatgatctct tctcaaagac agaagtgata tttttaacaa atattgtcac aagtaaatag   1560

caatcaaaag gagaaaataa cttttgtatt tttttaatgt gtttgatagc tttgacgagg   1620

gttctctttg ttactttcag gggagggcat cctattaaat gccacgccag cagtccgggt   1680

ctgggtttgt cccacaaaat cacaggagca ctgtatgttc ctctcttttg gagttgtgac   1740

tttgaagggc ctcaatatta gccacactgc cgcctgcaga aggtggagag ttaagatgtt   1800

ctatgtcaat ttgctcttgc cgaaaagatg agcctcgatt ttaaaatcta tccacatcca   1860

actgatggca ccattgatgt gcaaataatg agattcccta tctcctttta gacctgggac   1920

ggcaaaaggg aagggaagga aacttagcag agtgctattg actatagatt cacatattag   1980

caacaaaatc ccgtaattct tttggccaac agcagctatt ttggggagca gctgtggctg   2040

ttacataaat agagatgcag ccaaaatttt aggcctttta tcctgcttct agcagaaaaa   2100

tgcagggaga gtcaagtagt ctagggtttc aggttgcctc ccctcatatg gtttttggcc   2160

aagtgactaa aacagttttc cacaactgta aacaaactgc taagccccac ctcaaacttg   2220

ttcactgggg actttgctta ccgttctgtg ggtgaccttt tccgggattt cttgttctta   2280

tcaagcaaga attaagcaca tgctaaacgt cttccatttg acttctctac tcggtgtctc   2340

agacagtgtc ttcccagaaa accaccaccc tctacccaaa gatgaaacat gctcatgtca   2400

tttttctcat ggtcacattt aacagttttg acatgttata cttgcgcata gatccaagcg   2460

tttcttggga acctgacttt tgagtgttta ataaagccgg aagtggtgtt gccctgaacc   2520

agcagatttt cacctgggtt ctggctccgg tgtttaacac tggatacatc tttgatgtgc   2580

gaaagtgagt tcatcttcag acacatttgg tacatccaga aatagatcca agaaatgggg   2640

tggttgagtg ggtccgcacg aaatgcttga ttatgtcagc aacacccaac actgtctgtt   2700

ttccatttgt tggttttaat cataaaattg tcaagtgatt cgtgtttgta ctttattttt   2760

ttgtgccttc tgaaaggatc taaaacaaaa atattttgcc tttttttccc cacgtgtatc   2820

tgaacattaa gcagattggc tcagacacaa tgaaaaggat aatccaatgt acgtgctggt   2880

gcactctgct agttgttatc tctgtagggc tcaggaagct ggaaggagga agggagggta   2940

agtggcctgg tgagtggagg tagaaaaatg atgagaaatg aactgagagc attaagcaga   3000

gagggttgat aggctggccg tgtccggggt gaaattggaa atccagctgc ctagtggcca   3060

gtgggtgggg caagactgtc aacgagattt acagctggct tacacatgcc ttatgtcctc   3120

tgagttgtag agttgtaaaa gttcagcagt gtgtgcacag ctttcttttg gttggcagag   3180

attcaggatc atggagtact gctctcataa ttgaagacgt gtttgttatt ggcagagaac   3240

cttaaaaaag gcctttacct cagcgatgct tcctagcccc aggcttgcag agaacacaga   3300

gtggtgttgt ggtctattta gggacaaaga aggtataaag tccagagatg agaaaactgg   3360

gtcagccctc agaaactgca gcagccacgc acacagaagc ctgctggaag acaggtctct   3420

ctccgtccac agtgcccatc atctgagcct gggctgggat gactcaactt agcaaagacg   3480

gacccaggag gagtgctggt tcttcagtct ttgtactggc cccatcctct cctcactgta   3540

atgtgaggaa gcacctctgt gtcagggctc acctgggcat ccaaagcggc cacgcccaca   3600

atccgacagc ccccaggagc aggtccaggg atgatgcagc ccccttcttg gtcccatgtg   3660

atgtcatcct gctttgttat cttcttataa ctttatcctg ctataacttt atcctcttcc   3720

cagcctcatc cctgtttttc tgttagggca agactcttcc ataagcctgc taaaaaacag   3780

agatgatacc tcttacaaac tttacctcat agcctgtgaa gcaggttggc atgtggatta   3840

caagtcctgc tttgacactg ggcaagaatt taagattgtt ctatctctac tagtcataga   3900

aaagaaacat tgttaaacat gttgagtttt aaaggaagaa atattttcaa attcttaatc   3960

caagaaaata ctgagttgga atcttagact tcgggactct gacacgttct ttatgaaagg   4020

caaaataatt ggtatctaaa gttctctcct tcctgcctcc cctaaagaaa aaggatatta   4080

gattgcacac tataatttta cataagatct gccttccaca cttccctgct ggaaggcatt   4140

ctcagagctt tatgtcttcg tacctctcag agattggact ttttcttgtt taaaacccca   4200

accaaaaaaa ataataaggc atgattggtg gggagggaat gtgtatttag gggcataata   4260

aaaaggtggc tcgaagcagg aactttggcc tcatggtgtc atgggtggat gcctggactc   4320

cagtgtgcct gtgaggggct gggttaggca gtcggctgtc acactcacat gtgcctgcaa   4380

taaacctttt ggaatttcat gaacgaggtc tatgaattgc cttttgccaa tgaatggatg   4440

tatttttcca aggggggaat agtatccttg actttggcag tcaccttttt gtatgtctct   4500

agaaaggggt caaaaaacta tggtaaagat gaggcttatg agtgaatacc tctgggacaa   4560

accttaggac tcacaagcta tgccatgttt ttcaggagac tcttgtacct tatctggaat   4620

ctaatcttgg gagaagagga aaaaggagct aatatttgtc atttatactc actctgtgcc   4680

agatactgtg ctaggcattt tataattgtt ttgtgtcatc ctcatgataa tcctgtgaag   4740

tagatctatt acccccgtgt tctaaataat agatcttaag tgtggaatgc atctatccaa   4800

cataaatgcc catgttgaaa gaaggaaaga tgtcattcaa gtatttttca aattcttttt   4860

attatgacta tgcccttcgc aacactgtga aaacaacccc tgggggcatc tgccttccag   4920

aatctctctc tggcttctca ccagcttggt ttcctcatgg ggagtgtttt atttggcctc   4980

ccctatctga gctgcacaca caccagggga ggccactggc taacagtagg acttcagtgc   5040

cctgaggaaa aggctttggg aatttaggca cacgtttctc tccttggaat ccttctagca   5100

tctggaaaag gaacctggta tttctgcagt tagataccag atgcaaccag aacaggcttt   5160

cgagtgctgt gatttctttc ctgggttccc aagtcttgtt gtttcatcac aaactgtatc   5220

tttttaaggt taaaagtctt gaccttcatg ggggtctggg acaatccgat ctccaagcat   5280

ggaggaaagg caatgcctgg accactgact tgcattgaaa tcctttcttg tgggctaggg   5340

tttgatgtct ctttttcatc tttggactgg ggatctgcat cttccaggtc catttaagca   5400

ctgaaactag atgcaaatct ctttcgagac cttacatgtt ttagatagtc atgtaatgac   5460

ttggatagac atttaaataa cttgttccaa ggtcggaaga gcccaagaac tcctcagagt   5520

tcctcttctt gcttcttgaa tcacatcctc taaagatgac tcatgtctcc atagcaactg   5580

ttaaaggtgc tgcctagacg ggacccgctc ccacctttac ttactttgct cgaaggaacc   5640

aaaacaatgt ccttgtgtaa aggggctgtc atatccagtt ttcctttgaa atctggcccc   5700

caagatcctg cttctttcta acctggcagc tgtcatgtcc cttcaagatg atgtgggaaa   5760

tggcccttac aacttgggaa ccacagaaat tgctgtattt cgggaagatt cacctctaaa   5820

ctgaaggctt cattctgata gtgtctgccc tctctaccct gatttcgccc ttctttgctt   5880

ccatttttag cccaaggctt tgaatttgat tgagtaagac ttagaggcag tataaagaac   5940

accataaact taggcagagg tcccttaggg tctctagagt tgaaaataat tctacagcct   6000

tagggggacc tcttggcatt gactctaaag ggagagaata gcccctgtgt cctggcattt   6060

cagtctagac cttcaaggac tgttctctct tgacaggcaa gcaagcaaag aaagttttgc   6120

aatagatttc aagccagttt ttccattcaa accaagatgc aaattcataa aattactctt   6180

ttcctggaat agatccaggc agctgcctta ttagaacttt agattcggat ctattttctt   6240

aacacacata cacatacacg cgcatacata catatacaga gagatacgtg gagaaaggaa   6300

atttactcta tcattgcaat acttcaagaa agagctgtat tttgcctttc tgtaatctcc   6360

aagatagtgt ctaggaaagt aatagtataa ctatagggat accgaaacag gaaaaaccag   6420

ccatcactct tgagaaagtt tgagttcgac tcacatggga gaatcgaggt ctgctactcg   6480

tcttgctttg tgccccatct gtgcctggat gccctactac atctgcttga ctcgtctggg   6540

ctgctagccg gggtgttgtg gctgacatcc tttcctggcc ttacacacat aatagacaca   6600

tccctaacgg cgtgtgcctg gtccagccac atacagccac cacatgtgtc acacactgtc   6660

cccctcatcc atgtggactt gactggcatt tcagcagctc cactgggatg ctctaacccc   6720

agtgtgtgga gttggggtcc cttcatctag gttgacccag gtatagcatt tttagcattg   6780

cctttccagt cttgatgatt cattcattga actcatttat ttctggagcc cctggtacac   6840

tccaggcact gcgctaattg ccagcaaagc acaactgaac taaatccacc ttcaaggaac   6900

ctagccataa cgagggaggc agcatggaag taccctacag gggaaagtcc tgagtgctgt   6960

gggagcatct caccgtggca gccagcccag ttttggcaat caggggcttc ctgaaagagg   7020

tgacatcaaa gcccggatgt gtcagaggac tgagggagag tgttactaaa ggactttcag   7080

gctgagagga tagcacagga ctcagcccaa aggagggcca gtgtggactg tccagggcca   7140

gcctgcagta cagaggctgg agcttggact tgtagaggga gagagaagag caagggacgt   7200

ggacggggca gtgagccagg ctagccacag agggttcccg gggctttgct ggggattcag   7260

ggagcataaa taagagcttt aggtggtgct gtgtcctctg cagcccactg ctgaggtcct   7320

ccagacaggt aaggtgtggt cacaatcagg gccggggttt ccctgctcac tgcggcagtg   7380

caggggtgct tgctg                                                    7395


<210>  1287
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  1287


Met Lys Lys Leu Lys Arg Val Gly Ile Thr Val Arg Lys Lys Arg Ile 
1               5                   10                  15      


Ser His Ser Thr Asn Phe Thr Thr Gln Thr Arg Ser Tyr Tyr Cys Val 
            20                  25                  30          


Asn Arg Leu His Pro Ser 
        35              

<210>  1288
<211>  1027
<212>  DNA
<213>  Homo sapiens

<400>  1288
acttttcata gcagtgctcc ctgtttggca ggttctacct gttctgtgtg tcatctttgc     60

aaggactttt gcccttgtga ggaaaaaagt gccagctcaa atgtaagact taaaactaat    120

aaagaggttc cgggattagt tcatcaaccc agagcaaaca tgcacatctc tgaaagccaa    180

caagaattct tcagaatgct ggatgaaaaa attgaaaagg gtcgggatta ctgttcggaa    240

gaagaggata tcacatagca ccaattttac cactcaaacc aggagctact actgtgtaaa    300

taggttacac cccagttgaa atctttgcaa aggtcggttc tattcagcga acagcactat    360

agcaaaagaa gatcgttcca tattgtacgc cccattaaat tacagtgttt cttaatgaac    420

ttgcaaagga atattgctaa aaacaaacaa aaaaaactgt tatcgaactt tctttgttgc    480

tgctagttaa aacttgttgc aacttttcac ttctcttgtg tccaggtatg cagcaaaatt    540

ctgcaatttc accttaaaga tactgttggt tttacagatg ctctccaacc tattttctat    600

aagatgaggt agtggtgaac tcagataaca aacttctctt ctaaactggt tctgcttcta    660

agacaagcat ctcctgccct ctctccttcc tccccatctc tcgcacgcag tctagagatg    720

gactgagcct tgcttctcac tggcagtgtt gagctttgga gatgggatgg ttgctatgcc    780

aagccttgtt tctctgctca gaagaagtag agaagctatt atcaattaaa agcatgctgt    840

gatgtgactc ctggaagtga cgtaggagtg agtggcaggt tgtttgattt aataggtatc    900

ttaatcaaga attaagcttg caacattggc tttgctcaga tgcagatgga agtgtgatca    960

caatcatttt gaatccctct tcctcacttt tttttctaag aaaataaaca ttttactgtt   1020

tttatgg                                                             1027


<210>  1289
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  1289


Met Lys Lys Leu Lys Arg Val Gly Ile Thr Val Arg Lys Lys Arg Ile 
1               5                   10                  15      


Ser His Ser Thr Asn Phe Thr Thr Gln Thr Arg Ser Tyr Tyr Cys Val 
            20                  25                  30          


Asn Arg Leu His Pro Ser 
        35              

<210>  1290
<211>  2731
<212>  DNA
<213>  Homo sapiens

<400>  1290
acttttcata gcagtgctcc ctgtttggca ggttctacct gttctgtgtg tcatctttgc     60

aaggactttt gcccttgtga ggaaaaaagt gccagctcaa atgtaagact taaaactaat    120

aaagaggttc cgggattagt tcatcaaccc agagcaaaca tgcacatctc tgaaagccaa    180

caagaattct tcagaatgct ggatgaaaaa attgaaaagg gtcgggatta ctgttcggaa    240

gaagaggata tcacatagca ccaattttac cactcaaacc aggagctact actgtgtaaa    300

taggttacac cccagttgaa atctttgcaa aggtcggttc tattcagcga acagcactat    360

agcaaaagaa gatcgttcca tattgtacgc cccattaaat tacagtgttt cttaatgaac    420

ttgcaaagga atattgctaa aaacaaacaa aaaaaactgt tatcgaactt tctttgttgc    480

tgctagttaa aacttgttgc aacttttcac ttctcttgtg tccaggtatg cagcaaaatt    540

ctgcaatttc accttaaaga tactgttggt tttacagatg ctctccaacc tattttctat    600

aagatgaggt agtggtgaac tcagataaca aacttctctt ctaaactggt tctgcttcta    660

agacaagcat ctcctgccct ctctccttcc tccccatctc tcgcacgcag tctagagatg    720

gactgagcct tgcttctcac tggcagtgtt gagctttgga gatgggatgg ttgctatgcc    780

aagccttgtt tctctgctca gaagaagtag agaagctatt atcaattaaa agcatgctgt    840

gatgtgactc ctggaagtga cgtaggagtg agtggcaggt tgtttgattt aataggtatc    900

ttaatcaaga attaagcttg caacattggc tttgctcaga tgcagatgga agtgtgatca    960

caatcatttt gaatccctct tcctcacttt tttttctaag aaaataaaca ttttactgtt   1020

tttatggatc cttgtcttct cccattcatc cagctcagtg ttttaagatg atcctgggtg   1080

cagaagttga gccctccttt gcattgacac tgataattag cctatagggc tccctaccct   1140

tccattaaga atctaccaag cattagcaag gctgaaagtg gtctaagagg tgaggggaca   1200

tcctatgact ttttaggaag gcctgaaacc accttgttac ctttcatttt gttagcaaat   1260

aaaccatcct attttgtaac tctccccctt caaaatgcta catgagcctt gccacttcct   1320

ttttctctta cttccagcac actagacata gcaaaagtgt ttgcctactc aaaaacataa   1380

tacttttatg ctgatgatgg tatttggaga tgtgaaagcc aaaagcccct ggcagtggtg   1440

gggaatgttg actgagtgtt cagcagagtt tatttttcca tactatatga agagaatgat   1500

ctcttctcaa agacagaagt gatattttta acaaatattg tcacaagtaa atagcaatca   1560

aaaggagaaa ataacttttg tattttttta atgtgtttga tagctttgac gagggttctc   1620

tttgttactt tcaggggagg gcatcctatt aaatgccacg ccagcagtcc gggtctgggt   1680

ttgtcccaca aaatcacagg agcactgtat gttcctctct tttggagttg tgactttgaa   1740

gggcctcaat attagccaca ctgccgcctg cagaaggtgg agagttaaga tgttctatgt   1800

caatttgctc ttgccgaaaa gatgagcctc gattttaaaa tctatccaca tccaactgat   1860

ggcaccattg atgtgcaaat aatgagattc cctatctcct tttagacctg ggacggcaaa   1920

agggaaggga aggaaactta gcagagtgct attgactata gattcacata ttagcaacaa   1980

aatcccgtaa ttcttttggc caacagcagc tattttgggg agcagctgtg gctgttacat   2040

aaatagagat gcagccaaaa ttttaggcct tttatcctgc ttctagcaga aaaatgcagg   2100

gagagtcaag tagtctaggg tttcaggttg cctcccctca tatggttttt ggccaagtga   2160

ctaaaacagt tttccacaac tgtaaacaaa ctgctaagcc ccacctcaaa cttgttcact   2220

ggggactttg cttaccgttc tgtgggtgac cttttccggg atttcttgtt cttatcaagc   2280

aagaattaag cacatgctaa acgtcttcca tttgacttct ctactcggtg tctcagacag   2340

tgtcttccca gaaaaccacc accctctacc caaagatgaa acatgctcat gtcatttttc   2400

tcatggtcac atttaacagt tttgacatgt tatacttgcg catagatcca agcgtttctt   2460

gggaacctga cttttgagtg tttaataaag ccggaagtgg tgttgccctg aaccagcaga   2520

ttttcacctg ggttctggct ccggtgttta acactggata catctttgat gtgcgaaagt   2580

gagttcatct tcagacacat ttggtacatc cagaaataga tccaagaaat ggggtggttg   2640

agtgggtccg cacgaaatgc ttgattatgt cagcaacacc caacactgtc tgttttccat   2700

ttgttggttt taatcataaa attgtcaagt g                                  2731


<210>  1291
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  1291


Met Lys Lys Leu Lys Arg Val Gly Ile Thr Val Arg Lys Lys Arg Ile 
1               5                   10                  15      


Ser His Ser Thr Asn Phe Thr Thr Gln Thr Arg Ser Tyr Tyr Cys Val 
            20                  25                  30          


Asn Arg Leu His Pro Ser 
        35              

<210>  1292
<211>  7389
<212>  DNA
<213>  Homo sapiens

<400>  1292
acttttcata gcagtgctcc ctgtttggca ggttctacct gttctgtgtg tcatctttgc     60

aaggactttt gcccttgtga ggaaaaaagt gccagctcaa atgtaagact taaaactaat    120

aaagaggttc cgggattagt tcatcaaccc agagcaaaca tgcacatctc tgaaagccaa    180

caagaattct tcagaatgct ggatgaaaaa attgaaaagg gtcgggatta ctgttcggaa    240

gaagaggata tcacatagca ccaattttac cactcaaacc aggagctact actgtgtaaa    300

taggttacac cccagttgaa atctttgcaa aggtcggttc tattcagcga acagcactat    360

agcaaaagaa gatcgttcca tattgtacgc cccattaaat tacagtgttt cttaatgaac    420

ttgcaaagga atattgctaa aaacaaacaa aaaaaactgt tatcgaactt tctttgttgc    480

tgctagttaa aacttgttgc aacttttcac ttctcttgtg tccaggtatg cagcaaaatt    540

ctgcaatttc accttaaaga tactgttggt tttacagatg ctctccaacc tattttctat    600

aagatgaggt agtggtgaac tcagataaca aacttctctt ctaaactggt tctgcttcta    660

agacaagcat ctcctgccct ctctccttcc tccccatctc tcgcacgcag tctagagatg    720

gactgagcct tgcttctcac tggcagtgtt gagctttgga gatgggatgg ttgctatgcc    780

aagccttgtt tctctgctca gaagaagtag agaagctatt atcaattaaa agcatgctgt    840

gatgtgactc ctggaagtga cgtaggagtg agtggcaggt tgtttgattt aataggtatc    900

ttaatcaaga attaagcttg caacattggc tttgctcaga tgcagatgga agtgtgatca    960

caatcatttt gaatccctct tcctcacttt tttttctaag aaaataaaca ttttactgtt   1020

tttatggatc cttgtcttct cccattcatc cagctcagtg ttttaagatg atcctgggtg   1080

cagaagttga gccctccttt gcattgacac tgataattag cctatagggc tccctaccct   1140

tccattaaga atctaccaag cattagcaag gctgaaagtg gtctaagagg tgaggggaca   1200

tcctatgact ttttaggaag gcctgaaacc accttgttac ctttcatttt gttagcaaat   1260

aaaccatcct attttgtaac tctccccctt caaaatgcta catgagcctt gccacttcct   1320

ttttctctta cttccagcac actagacata gcaaaagtgt ttgcctactc aaaaacataa   1380

tacttttatg ctgatgatgg tatttggaga tgtgaaagcc aaaagcccct ggcagtggtg   1440

gggaatgttg actgagtgtt cagcagagtt tatttttcca tactatatga agagaatgat   1500

ctcttctcaa agacagaagt gatattttta acaaatattg tcacaagtaa atagcaatca   1560

aaaggagaaa ataacttttg tattttttta atgtgtttga tagctttgac gagggttctc   1620

tttgttactt tcaggggagg gcatcctatt aaatgccacg ccagcagtcc gggtctgggt   1680

ttgtcccaca aaatcacagg agcactgtat gttcctctct tttggagttg tgactttgaa   1740

gggcctcaat attagccaca ctgccgcctg cagaaggtgg agagttaaga tgttctatgt   1800

caatttgctc ttgccgaaaa gatgagcctc gattttaaaa tctatccaca tccaactgat   1860

ggcaccattg atgtgcaaat aatgagattc cctatctcct tttagacctg ggacggcaaa   1920

agggaaggga aggaaactta gcagagtgct attgactata gattcacata ttagcaacaa   1980

aatcccgtaa ttcttttggc caacagcagc tattttgggg agcagctgtg gctgttacat   2040

aaatagagat gcagccaaaa ttttaggcct tttatcctgc ttctagcaga aaaatgcagg   2100

gagagtcaag tagtctaggg tttcaggttg cctcccctca tatggttttt ggccaagtga   2160

ctaaaacagt tttccacaac tgtaaacaaa ctgctaagcc ccacctcaaa cttgttcact   2220

ggggactttg cttaccgttc tgtgggtgac cttttccggg atttcttgtt cttatcaagc   2280

aagaattaag cacatgctaa acgtcttcca tttgacttct ctactcggtg tctcagacag   2340

tgtcttccca gaaaaccacc accctctacc caaagatgaa acatgctcat gtcatttttc   2400

tcatggtcac atttaacagt tttgacatgt tatacttgcg catagatcca agcgtttctt   2460

gggaacctga cttttgagtg tttaataaag ccggaagtgg tgttgccctg aaccagcaga   2520

ttttcacctg ggttctggct ccggtgttta acactggata catctttgat gtgcgaaagt   2580

gagttcatct tcagacacat ttggtacatc cagaaataga tccaagaaat ggggtggttg   2640

agtgggtccg cacgaaatgc ttgattatgt cagcaacacc caacactgtc tgttttccat   2700

ttgttggttt taatcataaa attgtcaagt gattcgtgtt tgtactttat ttttttgtgc   2760

cttctgaaag gatctaaaac aaaaatattt tgcctttttt tccccacgtg tatctgaaca   2820

ttaagcagat tggctcagac acaatgaaaa ggataatcca atgtacgtgc tggtgcactc   2880

tgctagttgt tatctctgta gggctcagga agctggaagg aggaagggag ggtaagtggc   2940

ctggtgagtg gaggtagaaa aatgatgaga aatgaactga gagcattaag cagagagggt   3000

tgataggctg gccgtgtccg gggtgaaatt ggaaatccag ctgcctagtg gccagtgggt   3060

ggggcaagac tgtcaacgag atttacagct ggcttacaca tgccttatgt cctctgagtt   3120

gtagagttgt aaaagttcag cagtgtgtgc acagctttct tttggttggc agagattcag   3180

gatcatggag tactgctctc ataattgaag acgtgtttgt tattggcaga gaaccttaaa   3240

aaaggccttt acctcagcga tgcttcctag ccccaggctt gcagagaaca cagagtggtg   3300

ttgtggtcta tttagggaca aagaaggtat aaagtccaga gatgagaaaa ctgggtcagc   3360

cctcagaaac tgcagcagcc acgcacacag aagcctgctg gaagacaggt ctctctccgt   3420

ccacagtgcc catcatctga gcctgggctg ggatgactca acttagcaaa gacggaccca   3480

ggaggagtgc tggttcttca gtctttgtac tggccccatc ctctcctcac tgtaatgtga   3540

ggaagcacct ctgtgtcagg gctcacctgg gcatccaaag cggccacgcc cacaatccga   3600

cagcccccag gagcaggtcc agggatgatg cagccccctt cttggtccca tgtgatgtca   3660

tcctgctttg ttatcttctt ataactttat cctgctataa ctttatcctc ttcccagcct   3720

catccctgtt tttctgttag ggcaagactc ttccataagc ctgctaaaaa acagagatga   3780

tacctcttac aaactttacc tcatagcctg tgaagcaggt tggcatgtgg attacaagtc   3840

ctgctttgac actgggcaag aatttaagat tgttctatct ctactagtca tagaaaagaa   3900

acattgttaa acatgttgag ttttaaagga agaaatattt tcaaattctt aatccaagaa   3960

aatactgagt tggaatctta gacttcggga ctctgacacg ttctttatga aaggcaaaat   4020

aattggtatc taaagttctc tccttcctgc ctcccctaaa gaaaaaggat attagattgc   4080

acactataat tttacataag atctgccttc cacacttccc tgctggaagg cattctcaga   4140

gctttatgtc ttcgtacctc tcagagattg gactttttct tgtttaaaac cccaaccaaa   4200

aaaaataata aggcatgatt ggtggggagg gaatgtgtat ttaggggcat aataaaaagg   4260

tggctcgaag caggaacttt ggcctcatgg tgtcatgggt ggatgcctgg actccagtgt   4320

gcctgtgagg ggctgggtta ggcagtcggc tgtcacactc acatgtgcct gcaataaacc   4380

ttttggaatt tcatgaacga ggtctatgaa ttgccttttg ccaatgaatg gatgtatttt   4440

tccaaggggg gaatagtatc cttgactttg gcagtcacct ttttgtatgt ctctagaaag   4500

gggtcaaaaa actatggtaa agatgaggct tatgagtgaa tacctctggg acaaacctta   4560

ggactcacaa gctatgccat gtttttcagg agactcttgt accttatctg gaatctaatc   4620

ttgggagaag aggaaaaagg agctaatatt tgtcatttat actcactctg tgccagatac   4680

tgtgctaggc attttataat tgttttgtgt catcctcatg ataatcctgt gaagtagatc   4740

tattaccccc gtgttctaaa taatagatct taagtgtgga atgcatctat ccaacataaa   4800

tgcccatgtt gaaagaagga aagatgtcat tcaagtattt ttcaaattct ttttattatg   4860

actatgccct tcgcaacact gtgaaaacaa cccctggggg catctgcctt ccagaatctc   4920

tctctggctt ctcaccagct tggtttcctc atggggagtg ttttatttgg cctcccctat   4980

ctgagctgca cacacaccag gggaggccac tggctaacag taggacttca gtgccctgag   5040

gaaaaggctt tgggaattta ggcacacgtt tctctccttg gaatccttct agcatctgga   5100

aaaggaacct ggtatttctg cagttagata ccagatgcaa ccagaacagg ctttcgagtg   5160

ctgtgatttc tttcctgggt tcccaagtct tgttgtttca tcacaaactg tatcttttta   5220

aggttaaaag tcttgacctt catgggggtc tgggacaatc cgatctccaa gcatggagga   5280

aaggcaatgc ctggaccact gacttgcatt gaaatccttt cttgtgggct agggtttgat   5340

gtctcttttt catctttgga ctggggatct gcatcttcca ggtccattta agcactgaaa   5400

ctagatgcaa atctctttcg agaccttaca tgttttagat agtcatgtaa tgacttggat   5460

agacatttaa ataacttgtt ccaaggtcgg aagagcccaa gaactcctca gagttcctct   5520

tcttgcttct tgaatcacat cctctaaaga tgactcatgt ctccatagca actgttaaag   5580

gtgctgccta gacgggaccc gctcccacct ttacttactt tgctcgaagg aaccaaaaca   5640

atgtccttgt gtaaaggggc tgtcatatcc agttttcctt tgaaatctgg cccccaagat   5700

cctgcttctt tctaacctgg cagctgtcat gtcccttcaa gatgatgtgg gaaatggccc   5760

ttacaacttg ggaaccacag aaattgctgt atttcgggaa gattcacctc taaactgaag   5820

gcttcattct gatagtgtct gccctctcta ccctgatttc gcccttcttt gcttccattt   5880

ttagcccaag gctttgaatt tgattgagta agacttagag gcagtataaa gaacaccata   5940

aacttaggca gaggtccctt agggtctcta gagttgaaaa taattctaca gccttagggg   6000

gacctcttgg cattgactct aaagggagag aatagcccct gtgtcctggc atttcagtct   6060

agaccttcaa ggactgttct ctcttgacag gcaagcaagc aaagaaagtt ttgcaataga   6120

tttcaagcca gtttttccat tcaaaccaag atgcaaattc ataaaattac tcttttcctg   6180

gaatagatcc aggcagctgc cttattagaa ctttagattc ggatctattt tcttaacaca   6240

catacacata cacgcgcata catacatata cagagagata cgtggagaaa ggaaatttac   6300

tctatcattg caatacttca agaaagagct gtattttgcc tttctgtaat ctccaagata   6360

gtgtctagga aagtaatagt ataactatag ggataccgaa acaggaaaaa ccagccatca   6420

ctcttgagaa agtttgagtt cgactcacat gggagaatcg aggtctgcta ctcgtcttgc   6480

tttgtgcccc atctgtgcct ggatgcccta ctacatctgc ttgactcgtc tgggctgcta   6540

gccggggtgt tgtggctgac atcctttcct ggccttacac acataataga cacatcccta   6600

acggcgtgtg cctggtccag ccacatacag ccaccacatg tgtcacacac tgtccccctc   6660

atccatgtgg acttgactgg catttcagca gctccactgg gatgctctaa ccccagtgtg   6720

tggagttggg gtcccttcat ctaggttgac ccaggtatag catttttagc attgcctttc   6780

cagtcttgat gattcattca ttgaactcat ttatttctgg agcccctggt acactccagg   6840

cactgcgcta attgccagca aagcacaact gaactaaatc caccttcaag gaacctagcc   6900

ataacgaggg aggcagcatg gaagtaccct acaggggaaa gtcctgagtg ctgtgggagc   6960

atctcaccgt ggcagccagc ccagttttgg caatcagggg cttcctgaaa gaggtgacat   7020

caaagcccgg atgtgtcaga ggactgaggg agagtgttac taaaggactt tcaggctgag   7080

aggatagcac aggactcagc ccaaaggagg gccagtgtgg actgtccagg gccagcctgc   7140

agtacagagg ctggagcttg gacttgtaga gggagagaga agagcaaggg acgtggacgg   7200

ggcagtgagc caggctagcc acagagggtt cccggggctt tgctggggat tcagggagca   7260

taaataagag ctttaggtgg tgctgtgtcc tctgcagccc actgctgagg tcctccagac   7320

aggtaaggtg tggtcacaat cagggccggg gtttccctgc tcactgcggc agtgcagggg   7380

tgcttgctg                                                           7389


<210>  1293
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  1293


Met Lys Lys Leu Lys Arg Val Gly Ile Thr Val Arg Lys Lys Arg Ile 
1               5                   10                  15      


Ser His Ser Thr Asn Phe Thr Thr Gln Thr Arg Ser Tyr Tyr Cys Val 
            20                  25                  30          


Asn Arg Leu His Pro Ser 
        35              

<210>  1294
<211>  748
<212>  DNA
<213>  Homo sapiens

<400>  1294
tgagcctcga ttttaaaatc tatccacatc caactgatgg caccattgat gtgcaaataa     60

tgagattccc tatctccttt tagacctggg acggcaaaag ggaagggaag gaaacttagc    120

agagtgctat tgactataga ttcacatatt agcaacaaaa tcccgtaatt cttttggcca    180

acattttcca caactgtaaa caaactgcta agccccacct caaacttgtt cactggggac    240

tttgcttacc gttctgtggg tgaccttttc cgggatttct tgttcttatc aagcaagaat    300

taagcacatg ctaaacgtct tccatttgac ttctctactc ggtgtctcag acagtgtctt    360

cccagaaaac caccaccctc tacccaaaga tgaaacatgc tcatgtcatt tttctcatgg    420

tcacatttaa cagttttgac atgttatact tgcgcataga tccaagcgtt tcttgggaac    480

ctgacttttg agtgtttaat aaagccggaa gtggtgttgc cctgaaccag cagattttca    540

cctgggttct ggctccggtg tttaacactg gatacatctt tgatgtgcga aagtgagttc    600

atcttcagac acatttggta catccagaaa tagatccaag aaatggggtg gttgagtggg    660

tccgcacgaa atgcttgatt atgtcagcaa cacccaacac tgtctgtttt ccatttgttg    720

gttttaatca taaaattgtc aagtgatt                                       748


<210>  1295
<211>  40
<212>  PRT
<213>  Homo sapiens

<400>  1295


Met Leu Asn Val Phe His Leu Thr Ser Leu Leu Gly Val Ser Asp Ser 
1               5                   10                  15      


Val Phe Pro Glu Asn His His Pro Leu Pro Lys Asp Glu Thr Cys Ser 
            20                  25                  30          


Cys His Phe Ser His Gly His Ile 
        35                  40  

<210>  1296
<211>  5403
<212>  DNA
<213>  Homo sapiens

<400>  1296
tgagcctcga ttttaaaatc tatccacatc caactgatgg caccattgat gtgcaaataa     60

tgagattccc tatctccttt tagacctggg acggcaaaag ggaagggaag gaaacttagc    120

agagtgctat tgactataga ttcacatatt agcaacaaaa tcccgtaatt cttttggcca    180

acattttcca caactgtaaa caaactgcta agccccacct caaacttgtt cactggggac    240

tttgcttacc gttctgtggg tgaccttttc cgggatttct tgttcttatc aagcaagaat    300

taagcacatg ctaaacgtct tccatttgac ttctctactc ggtgtctcag acagtgtctt    360

cccagaaaac caccaccctc tacccaaaga tgaaacatgc tcatgtcatt tttctcatgg    420

tcacatttaa cagttttgac atgttatact tgcgcataga tccaagcgtt tcttgggaac    480

ctgacttttg agtgtttaat aaagccggaa gtggtgttgc cctgaaccag cagattttca    540

cctgggttct ggctccggtg tttaacactg gatacatctt tgatgtgcga aagtgagttc    600

atcttcagac acatttggta catccagaaa tagatccaag aaatggggtg gttgagtggg    660

tccgcacgaa atgcttgatt atgtcagcaa cacccaacac tgtctgtttt ccatttgttg    720

gttttaatca taaaattgtc aagtgattcg tgtttgtact ttattttttt gtgccttctg    780

aaaggatcta aaacaaaaat attttgcctt tttttcccca cgtgtatctg aacattaagc    840

agattggctc agacacaatg aaaaggataa tccaatgtac gtgctggtgc actctgctag    900

ttgttatctc tgtagggctc aggaagctgg aaggaggaag ggagggtaag tggcctggtg    960

agtggaggta gaaaaatgat gagaaatgaa ctgagagcat taagcagaga gggttgatag   1020

gctggccgtg tccggggtga aattggaaat ccagctgcct agtggccagt gggtggggca   1080

agactgtcaa cgagatttac agctggctta cacatgcctt atgtcctctg agttgtagag   1140

ttgtaaaagt tcagcagtgt gtgcacagct ttcttttggt tggcagagat tcaggatcat   1200

ggagtactgc tctcataatt gaagacgtgt ttgttattgg cagagaacct taaaaaaggc   1260

ctttacctca gcgatgcttc ctagccccag gcttgcagag aacacagagt ggtgttgtgg   1320

tctatttagg gacaaagaag gtataaagtc cagagatgag aaaactgggt cagccctcag   1380

aaactgcagc agccacgcac acagaagcct gctggaagac aggtctctct ccgtccacag   1440

tgcccatcat ctgagcctgg gctgggatga ctcaacttag caaagacgga cccaggagga   1500

gtgctggttc ttcagtcttt gtactggccc catcctctcc tcactgtaat gtgaggaagc   1560

acctctgtgt cagggctcac ctgggcatcc aaagcggcca cgcccacaat ccgacagccc   1620

ccaggagcag gtccagggat gatgcagccc ccttcttggt cccatgtgat gtcatcctgc   1680

tttgttatct tcttataact ttatcctgct ataactttat cctcttccca gcctcatccc   1740

tgtttttctg ttagggcaag actcttccat aagcctgcta aaaaacagag atgatacctc   1800

ttacaaactt tacctcatag cctgtgaagc aggttggcat gtggattaca agtcctgctt   1860

tgacactggg caagaattta agattgttct atctctacta gtcatagaaa agaaacattg   1920

ttaaacatgt tgagttttaa aggaagaaat attttcaaat tcttaatcca agaaaatact   1980

gagttggaat cttagacttc gggactctga cacgttcttt atgaaaggca aaataattgg   2040

tatctaaagt tctctccttc ctgcctcccc taaagaaaaa ggatattaga ttgcacacta   2100

taattttaca taagatctgc cttccacact tccctgctgg aaggcattct cagagcttta   2160

tgtcttcgta cctctcagag attggacttt ttcttgttta aaaccccaac caaaaaaaat   2220

aataaggcat gattggtggg gagggaatgt gtatttaggg gcataataaa aaggtggctc   2280

gaagcaggaa ctttggcctc atggtgtcat gggtggatgc ctggactcca gtgtgcctgt   2340

gaggggctgg gttaggcagt cggctgtcac actcacatgt gcctgcaata aaccttttgg   2400

aatttcatga acgaggtcta tgaattgcct tttgccaatg aatggatgta tttttccaag   2460

gggggaatag tatccttgac tttggcagtc acctttttgt atgtctctag aaaggggtca   2520

aaaaactatg gtaaagatga ggcttatgag tgaatacctc tgggacaaac cttaggactc   2580

acaagctatg ccatgttttt caggagactc ttgtacctta tctggaatct aatcttggga   2640

gaagaggaaa aaggagctaa tatttgtcat ttatactcac tctgtgccag atactgtgct   2700

aggcatttta taattgtttt gtgtcatcct catgataatc ctgtgaagta gatctattac   2760

ccccgtgttc taaataatag atcttaagtg tggaatgcat ctatccaaca taaatgccca   2820

tgttgaaaga aggaaagatg tcattcaagt atttttcaaa ttctttttat tatgactatg   2880

cccttcgcaa cactgtgaaa acaacccctg ggggcatctg ccttccagaa tctctctctg   2940

gcttctcacc agcttggttt cctcatgggg agtgttttat ttggcctccc ctatctgagc   3000

tgcacacaca ccaggggagg ccactggcta acagtaggac ttcagtgccc tgaggaaaag   3060

gctttgggaa tttaggcaca cgtttctctc cttggaatcc ttctagcatc tggaaaagga   3120

acctggtatt tctgcagtta gataccagat gcaaccagaa caggctttcg agtgctgtga   3180

tttctttcct gggttcccaa gtcttgttgt ttcatcacaa actgtatctt tttaaggtta   3240

aaagtcttga ccttcatggg ggtctgggac aatccgatct ccaagcatgg aggaaaggca   3300

atgcctggac cactgacttg cattgaaatc ctttcttgtg ggctagggtt tgatgtctct   3360

ttttcatctt tggactgggg atctgcatct tccaggtcca tttaagcact gaaactagat   3420

gcaaatctct ttcgagacct tacatgtttt agatagtcat gtaatgactt ggatagacat   3480

ttaaataact tgttccaagg tcggaagagc ccaagaactc ctcagagttc ctcttcttgc   3540

ttcttgaatc acatcctcta aagatgactc atgtctccat agcaactgtt aaaggtgctg   3600

cctagacggg acccgctccc acctttactt actttgctcg aaggaaccaa aacaatgtcc   3660

ttgtgtaaag gggctgtcat atccagtttt cctttgaaat ctggccccca agatcctgct   3720

tctttctaac ctggcagctg tcatgtccct tcaagatgat gtgggaaatg gcccttacaa   3780

cttgggaacc acagaaattg ctgtatttcg ggaagattca cctctaaact gaaggcttca   3840

ttctgatagt gtctgccctc tctaccctga tttcgccctt ctttgcttcc atttttagcc   3900

caaggctttg aatttgattg agtaagactt agaggcagta taaagaacac cataaactta   3960

ggcagaggtc ccttagggtc tctagagttg aaaataattc tacagcctta gggggacctc   4020

ttggcattga ctctaaaggg agagaatagc ccctgtgtcc tggcatttca gtctagacct   4080

tcaaggactg ttctctcttg acaggcaagc aagcaaagaa agttttgcaa tagatttcaa   4140

gccagttttt ccattcaaac caagatgcaa attcataaaa ttactctttt cctggaatag   4200

atccaggcag ctgccttatt agaactttag attcggatct attttcttaa cacacataca   4260

catacacgcg catacataca tatacagaga gatacgtgga gaaaggaaat ttactctatc   4320

attgcaatac ttcaagaaag agctgtattt tgcctttctg taatctccaa gatagtgtct   4380

aggaaagtaa tagtataact atagggatac cgaaacagga aaaaccagcc atcactcttg   4440

agaaagtttg agttcgactc acatgggaga atcgaggtct gctactcgtc ttgctttgtg   4500

ccccatctgt gcctggatgc cctactacat ctgcttgact cgtctgggct gctagccggg   4560

gtgttgtggc tgacatcctt tcctggcctt acacacataa tagacacatc cctaacggcg   4620

tgtgcctggt ccagccacat acagccacca catgtgtcac acactgtccc cctcatccat   4680

gtggacttga ctggcatttc agcagctcca ctgggatgct ctaaccccag tgtgtggagt   4740

tggggtccct tcatctaggt tgacccaggt atagcatttt tagcattgcc tttccagtct   4800

tgatgattca ttcattgaac tcatttattt ctggagcccc tggtacactc caggcactgc   4860

gctaattgcc agcaaagcac aactgaacta aatccacctt caaggaacct agccataacg   4920

agggaggcag catggaagta ccctacaggg gaaagtcctg agtgctgtgg gagcatctca   4980

ccgtggcagc cagcccagtt ttggcaatca ggggcttcct gaaagaggtg acatcaaagc   5040

ccggatgtgt cagaggactg agggagagtg ttactaaagg actttcaggc tgagaggata   5100

gcacaggact cagcccaaag gagggccagt gtggactgtc cagggccagc ctgcagtaca   5160

gaggctggag cttggacttg tagagggaga gagaagagca agggacgtgg acggggcagt   5220

gagccaggct agccacagag ggttcccggg gctttgctgg ggattcaggg agcataaata   5280

agagctttag gtggtgctgt gtcctctgca gcccactgct gaggtcctcc agacaggtaa   5340

ggtgtggtca caatcagggc cggggtttcc ctgctcactg cggcagtgca ggggtgcttg   5400

ctg                                                                 5403


<210>  1297
<211>  95
<212>  PRT
<213>  Homo sapiens

<400>  1297


Met Thr Gln Leu Ser Lys Asp Gly Pro Arg Arg Ser Ala Gly Ser Ser 
1               5                   10                  15      


Val Phe Val Leu Ala Pro Ser Ser Pro His Cys Asn Val Arg Lys His 
            20                  25                  30          


Leu Cys Val Arg Ala His Leu Gly Ile Gln Ser Gly His Ala His Asn 
        35                  40                  45              


Pro Thr Ala Pro Arg Ser Arg Ser Arg Asp Asp Ala Ala Pro Phe Leu 
    50                  55                  60                  


Val Pro Cys Asp Val Ile Leu Leu Cys Tyr Leu Leu Ile Thr Leu Ser 
65                  70                  75                  80  


Cys Tyr Asn Phe Ile Leu Phe Pro Ala Ser Ser Leu Phe Phe Cys 
                85                  90                  95  

<210>  1298
<211>  5231
<212>  DNA
<213>  Homo sapiens

<400>  1298
acagaaattg ctgtatttcg ggaagattca cctctaaact gaaggcttca ttctgatagt     60

gtctgccctc tctaccctga tttcgccctt ctttgcttcc atttttagcc caaggctttg    120

aatttgattg agtaagactt agaggcagta taaagaacac cataaactta ggcagaggtc    180

ccttagggtc tctagagttg aaaataattc tacagcctta gggggacctc ttggcattga    240

ctctaaaggg agagaatagc ccctgtgtcc tggcatttca gtctagacct tcaaggactg    300

ttctctcttg acaggcaagc aagcaaagaa agttttgcaa tagatttcaa gccagttttt    360

ccattcaaac caagatgcaa attcataaaa ttactctttt cctggaatag atccaggcag    420

ctgccttatt agaactttag attcggatct attttcttaa cacacataca catacacgcg    480

catacataca tatacagaga gatacgtgga gaaaggaaat ttactctatc attgcaatac    540

ttcaagaaag agctgtattt tgcctttctg taatctccaa gatagtgtct aggaaagtaa    600

tagtataact atagggatac cgaaacagga aaaaccagcc atcactcttg agaaagtttg    660

agttcgactc acatgggaga atcgaggtct gctactcgtc ttgctttgtg ccccatgtgt    720

gcctggtcca gccacataca gccaccacat gtgtcacaca ctggccaggc tagccacaga    780

gggttcccgg ggctttgctg gggattcagg gagcataaat aagagcttta ggtggtgctg    840

tgtcctctgc agcccactgc tgaggtcctc cagacaggta aggtgtggtc acaatcaggg    900

ccggggtttc cctgctcact gcggcagtgc aggggtgctt gctgagatga ttcatcccag    960

ggtgtcctct gtcccttacc cagccccaac tcctcttcct ctgccaaaag ctatttgaat   1020

tcaaggactt taacctgggc cggatctggt ttggagacaa aggggacagc tctgggtcag   1080

catgaccttc tttagagcca ctaaggcgaa aaataccgtt tgggaccagg ctggcctaga   1140

cccagggatg agaatgcacc ctaaaataaa tatacgggaa gcagcagagg gcttccctgt   1200

ctagtgtgtg atcctaacta aaggcagctc tcttggacag ccttcccctg gattaggtca   1260

catacacctg gtggccaagc ctctgctggg tcccaaatac acacccgagt cctgccaaag   1320

aaaggagatt tttaaaaagc acagacaaat tgtatgcaag tggaaaatac ccataggcct   1380

agacagctgt ggagggaaga cctcgtgggt acctggaggc tgccagagct gggagctctg   1440

caggtatgag tcagggaagg ctcagagaca agcagaatct ctctatggag acaacttgca   1500

gtgcctttta ggttttccaa ataacctcgg agttcagagc attgggtttt tttctcccct   1560

ccccaccccc agaaaaataa ttagaaaaat gtttaggaga aaggaaaaga attagatgca   1620

tcagaatacc agctataagc caacactgtt tccagaaact caagaaaaag ctcaaacaga   1680

agacagttcc cctgagaggc tggaggcgtt ggtgctgaag gcaattttcc tagctaaggg   1740

gcactgggcc ttgctgcacc ttggggctga ccttttttgc aaaacaccca cccctgccct   1800

cctggcatac tcaacagcaa cgccagcttt ctggaccctt ggaaagatgt tagctcaaac   1860

acccactttt tccagatctt cctcttgctc ttcactgagg aatttgtaat tctgaggcta   1920

gcgatgccca ctcggatatt ccgcaggccc aggtgtttag attagaattt gtccagcggt   1980

aatcctgatg ctggaaacca acaaacattt ggcctcatat tcacccattt aaaaactaga   2040

gcccctggca ggtcccctta gggccatgtg ttcatggaat ataagccaag tttgccttag   2100

gcttgttcat ggaatataag ccaagtttac ctctccccat tttctgccct ggcccacttc   2160

ccactcacct ccacctcatt gccaggaagg gatcaaaatg cctccatgcc agttgttaat   2220

ggctacatat ttgcccttcc caagggtatt tgcattttat ttaggaacat ggccttatat   2280

tcaaggaaaa tctagcatca agattacgag gcatcacctc tcaatcaggt ctgggaggta   2340

tcttggggca ttgctcttct gaacacctgc agaggcttcc tcaggtgagt gtgggagccc   2400

ggaagggtgg cctccctaac cactctgcct gcacatgaat tctccaaagc ttgctttagt   2460

gcaaatcagc acgcctaaat agcatcccaa accactgtgc gacatttggc ctgcagaata   2520

agaaagtcct aaggcagaat ccccaggaac ttcaaatctg ggagatgagg aaagaaaact   2580

cactcacaaa caacataaat gtaaataatt caaaacccta aaggagagct gtccctagac   2640

agtagtggct acaggtgcta agcaaaagtc aggtacactg gacagagcca tgcgattgat   2700

tgttcatctt ccctctctgg gtctccagaa aaggacactg gcaatatccc cagctctctc   2760

ctgattggaa ttctttgaac cctcgaagtg ctccagcagt actacccccc acgtagcagt   2820

gggcccatgt cgcttgaata ttatttttga tttgaccacc aagatgtaat gatgattcta   2880

ttccattttg aaaagggtct gagaaagtgt acaggtctaa ttatatatac atatttatac   2940

atgtgtattt ttgtttattg ttacattttg acattggact ttctattaaa taatttttaa   3000

gagttggcct ggctttgttc tcttttatgt ctttcttctt tcctttctca tggaggaggc   3060

cattgtaaat atctgcaaaa gaccctgtta gtgtccttgt ccctcctctc tttttgcctt   3120

ccctatttcg tgtacataag ggcttctctt accattcgta aatgttctgt ttttactgga   3180

tatgtggtac agcaggcacc catatggaag gcccccaacc ttgttgtcac ctcctccaac   3240

tttcagggac agcccacact gtcctatcag cctcagcaaa ttcacaaatt cagacctgat   3300

gaaggtgcaa gaatgggcaa tgcataaaat aacgccatga gccttctctc ctgctcaatc   3360

cccacactaa aaacaatcat tttctcatga gtttgacttg aggagatccc acaggaagtg   3420

cttaatgaac aaccttctgt tacacaatga ctcttttttg tttattcatt ctactcattc   3480

agctgacatt tgttaattgt acagtgtatg ccagggcctg ggtcacccac aaaggggctc   3540

agggatgtgt gaatttaagg aattccccac tccaaggtca aaggccagag tggcagcatg   3600

aagaatgagg ccagtaccat atagtttctc acatacccca ctgtcaacta taactacctg   3660

gcatgtttta gaggctgaaa acatatggat tctcccactg cactggcctt ccaggattta   3720

ccgaacagaa atacgcacac acatggacaa acggtctcag ggcactttgt caaagcatga   3780

agccaaaagc tgtttccctc tgctctgtct tcactgtcgc atgagcctgt tcatttctga   3840

caagcgttgg tcccatcagc ccagccagcc ttccgccctc cagccttgct cttgggaaca   3900

gattgtcttc atgatttcca actggtgtgg tgagaaggag ggagggaggg aggtcaagcc   3960

aaggacaggg gaaggagttg ataactattc ctaggcttct tcctccaagc catggagctg   4020

gaagttcaga tttgctgctg agttttatga gctgtcaaat aaggcaaaag gaaacttggg   4080

acccaaactt gttctttcag taacaacaaa cctgtttctt ccagcagagg cttacttgaa   4140

atcacaaagg ccagccaagc tgaaagagct ccctaactcc acctaccttc ccctgtctct   4200

ctctctcaca cacacacaca cacacacaca cacacacaca cacacacaca cacacacaca   4260

cacaaagctg gtctcccgta cctctgactg gaacttgggg agcttcctta gtctcatgcc   4320

gaagaggagt caagcttagg agacctctgg tctgcttctt ggtgctccct gaatgcttgt   4380

tagtgacgtc agcttccagt ttactggtaa cagctggact gctgccggag gccagtaacc   4440

tggagttctc ttgcttggaa gcaggtgatg ggaagtggga tgtgagtgat ggagggaaaa   4500

ggaagctcaa ctccaccgag cctcaacact tgatggatgg ggcaaagtga ggaaacagac   4560

cacagaagca caggagtaag ccactgtttc tgcccctcaa gggtctccag gccaccatca   4620

tccctgccac tggcactgcc caacctgcca cttccttcta caaagctgaa atgcagtaat   4680

ctgatggagg acacaaacct ttaacttcct cagttcacat cacgttacta atccagcctc   4740

ctactctcca gcagcactca gcttccatct gctggccagc tctttacgtg gtcctctcct   4800

gacactacca cgttcctttg cctatgctgg ctcttgctgt cccttcgcca agaaaactct   4860

cccatttctc cttcccactg ggaaccaagc ctcctctgag ttccagttaa tattgagcac   4920

tcacatgaag tctcctcacc gtatgaccta acatatgccc ttcgttcctg ccaaagaaca   4980

ttccctttag gaggggccgg gtgtgggtgg caaggtgggg taggaatccc tgacaaggat   5040

gatccaggga gaattctggt gagtaagacc tggtcttcaa gtgcaacttg gtcttcaaga   5100

gccaagttgc catgctgagg aagggtgacc ccagagcaga gcctaggcca ggtgaggagc   5160

aggtctgaga gacgcgatga tcacagagag tggaacacct gtgtttaagg acatggctac   5220

agaacataca t                                                        5231


<210>  1299
<211>  89
<212>  PRT
<213>  Homo sapiens

<400>  1299


Met Cys His Thr Leu Ala Arg Leu Ala Thr Glu Gly Ser Arg Gly Phe 
1               5                   10                  15      


Ala Gly Asp Ser Gly Ser Ile Asn Lys Ser Phe Arg Trp Cys Cys Val 
            20                  25                  30          


Leu Cys Ser Pro Leu Leu Arg Ser Ser Arg Gln Val Arg Cys Gly His 
        35                  40                  45              


Asn Gln Gly Arg Gly Phe Pro Ala His Cys Gly Ser Ala Gly Val Leu 
    50                  55                  60                  


Ala Glu Met Ile His Pro Arg Val Ser Ser Val Pro Tyr Pro Ala Pro 
65                  70                  75                  80  


Thr Pro Leu Pro Leu Pro Lys Ala Ile 
                85                  

<210>  1300
<211>  1694
<212>  DNA
<213>  Homo sapiens

<400>  1300
gtgtgaggcc gtgtgggagg ccggaagttg cggcttcatt actcgccatt tcaaaatgct     60

gccgaggccc taggatctgt gactgccacc cctcccccca cccgggctcg gcgggggagc    120

gactcatgga gctgccgtaa gttttaccaa cagactgcag tttcttcact accaaaatga    180

catcattttc cacctctgct cagtgttcaa catctgacag tgcttgcagg atctctcctg    240

gacaaatcaa tcaggtacga ccaaaactgc cgcttttgaa gattttgcat gcagcaggtg    300

cgcaaggtga aatgttcact gttaaagagg tcatgcacta tttaggtcag tacataatgg    360

tgaagcaact ttatgatcag caggagcagc atatggtata ttgtggtgga gatcttttgg    420

gagaactact gggacgtcag agcttctccg tgaaagaccc aagccctctc tatgatatgc    480

taagaaagaa tcttgtcact ttagccactg ctactacaga tgctgctcag actctcgctc    540

tcgcacagga tcacagtatg gatattccaa gtcaagacca actgaagcaa agtgcagagg    600

aaagttccac ttccagaaaa agaactacag aagacgatat ccccacactg cctacctcag    660

agcataaatg catacattct agagaagatg aagacttaat tgaaaattta gcccaagatg    720

aaacatctag gctggacctt ggatttgagg agtgggatgt agctggcctg ccttggtggt    780

ttttaggaaa cttgagaagc aactatacac ctagaagtaa tggctcaact gatttacaga    840

caaatcagga tgtgggtact gccattgttt cagatactac agatgacttg tggtttttga    900

atgagtcagt atcagagcag ttaggtgttg gaataaaagt tgaagctgct gatactgaac    960

aaacaagtga agaagtaggg aaagtaagtg acaaaaaggt gattgaagtg ggaaaaaatg   1020

atgacctgga ggactctaag tccttaagtg atgataccga tgtagaggtt acctctgagg   1080

atgagtggca gtgtactgaa tgcaagaaat ttaactctcc aagcaagagg tactgttttc   1140

gttgttgggc cttgaggaag gattggtatt cagattgttc aaagttaacc cattctctct   1200

ccacgtctga tatcactgcc atacctgaaa aggaaaatga aggaaatgat gtccctgatt   1260

gtcgaagaac catttcggct cctgtcgtta gacctaaaga tgcgtatata aagaaagaaa   1320

actccaaact ttttgatccc tgcaactcag tggaattctt ggatttggct cacagttctg   1380

aaagccaaga gaccatctca agcatgggag aacagttaga taacctttct gaacagagaa   1440

cagatacaga aaacatggag gattgccaga atctcttgaa gccatgtagc ttatgtgaga   1500

aaagaccacg agacgggaac attattcatg gaaggacggg ccatcttgtc acttgttttc   1560

actgtgccag aagactaaag aaggctgggg cttcatgccc tatttgcaag aaagagattc   1620

agctggttat taaggttttt atagcataat ggtagtacga acataaaaat gcatttattc   1680

cgttcactta ccac                                                     1694


<210>  1301
<211>  490
<212>  PRT
<213>  Homo sapiens

<400>  1301


Met Thr Ser Phe Ser Thr Ser Ala Gln Cys Ser Thr Ser Asp Ser Ala 
1               5                   10                  15      


Cys Arg Ile Ser Pro Gly Gln Ile Asn Gln Val Arg Pro Lys Leu Pro 
            20                  25                  30          


Leu Leu Lys Ile Leu His Ala Ala Gly Ala Gln Gly Glu Met Phe Thr 
        35                  40                  45              


Val Lys Glu Val Met His Tyr Leu Gly Gln Tyr Ile Met Val Lys Gln 
    50                  55                  60                  


Leu Tyr Asp Gln Gln Glu Gln His Met Val Tyr Cys Gly Gly Asp Leu 
65                  70                  75                  80  


Leu Gly Glu Leu Leu Gly Arg Gln Ser Phe Ser Val Lys Asp Pro Ser 
                85                  90                  95      


Pro Leu Tyr Asp Met Leu Arg Lys Asn Leu Val Thr Leu Ala Thr Ala 
            100                 105                 110         


Thr Thr Asp Ala Ala Gln Thr Leu Ala Leu Ala Gln Asp His Ser Met 
        115                 120                 125             


Asp Ile Pro Ser Gln Asp Gln Leu Lys Gln Ser Ala Glu Glu Ser Ser 
    130                 135                 140                 


Thr Ser Arg Lys Arg Thr Thr Glu Asp Asp Ile Pro Thr Leu Pro Thr 
145                 150                 155                 160 


Ser Glu His Lys Cys Ile His Ser Arg Glu Asp Glu Asp Leu Ile Glu 
                165                 170                 175     


Asn Leu Ala Gln Asp Glu Thr Ser Arg Leu Asp Leu Gly Phe Glu Glu 
            180                 185                 190         


Trp Asp Val Ala Gly Leu Pro Trp Trp Phe Leu Gly Asn Leu Arg Ser 
        195                 200                 205             


Asn Tyr Thr Pro Arg Ser Asn Gly Ser Thr Asp Leu Gln Thr Asn Gln 
    210                 215                 220                 


Asp Val Gly Thr Ala Ile Val Ser Asp Thr Thr Asp Asp Leu Trp Phe 
225                 230                 235                 240 


Leu Asn Glu Ser Val Ser Glu Gln Leu Gly Val Gly Ile Lys Val Glu 
                245                 250                 255     


Ala Ala Asp Thr Glu Gln Thr Ser Glu Glu Val Gly Lys Val Ser Asp 
            260                 265                 270         


Lys Lys Val Ile Glu Val Gly Lys Asn Asp Asp Leu Glu Asp Ser Lys 
        275                 280                 285             


Ser Leu Ser Asp Asp Thr Asp Val Glu Val Thr Ser Glu Asp Glu Trp 
    290                 295                 300                 


Gln Cys Thr Glu Cys Lys Lys Phe Asn Ser Pro Ser Lys Arg Tyr Cys 
305                 310                 315                 320 


Phe Arg Cys Trp Ala Leu Arg Lys Asp Trp Tyr Ser Asp Cys Ser Lys 
                325                 330                 335     


Leu Thr His Ser Leu Ser Thr Ser Asp Ile Thr Ala Ile Pro Glu Lys 
            340                 345                 350         


Glu Asn Glu Gly Asn Asp Val Pro Asp Cys Arg Arg Thr Ile Ser Ala 
        355                 360                 365             


Pro Val Val Arg Pro Lys Asp Ala Tyr Ile Lys Lys Glu Asn Ser Lys 
    370                 375                 380                 


Leu Phe Asp Pro Cys Asn Ser Val Glu Phe Leu Asp Leu Ala His Ser 
385                 390                 395                 400 


Ser Glu Ser Gln Glu Thr Ile Ser Ser Met Gly Glu Gln Leu Asp Asn 
                405                 410                 415     


Leu Ser Glu Gln Arg Thr Asp Thr Glu Asn Met Glu Asp Cys Gln Asn 
            420                 425                 430         


Leu Leu Lys Pro Cys Ser Leu Cys Glu Lys Arg Pro Arg Asp Gly Asn 
        435                 440                 445             


Ile Ile His Gly Arg Thr Gly His Leu Val Thr Cys Phe His Cys Ala 
    450                 455                 460                 


Arg Arg Leu Lys Lys Ala Gly Ala Ser Cys Pro Ile Cys Lys Lys Glu 
465                 470                 475                 480 


Ile Gln Leu Val Ile Lys Val Phe Ile Ala 
                485                 490 

<210>  1302
<211>  2683
<212>  DNA
<213>  Homo sapiens

<400>  1302
gtgtgaggcc gtgtgggagg ccggaagttg cggcttcatt actcgccatt tcaaaatgct     60

gccgaggccc taggatctgt gactgccacc cctcccccca cccgggctcg gcgggggagc    120

gactcatgga gctgccgtaa gttttaccaa cagactgcag tttcttcact accaaaatga    180

catcattttc cacctctgct cagtgttcaa catctgacag tgcttgcagg atctctcctg    240

gacaaatcaa tcaggtacga ccaaaactgc cgcttttgaa gattttgcat gcagcaggtg    300

cgcaaggtga aatgttcact gttaaagagg tcatgcacta tttaggtcag tacataatgg    360

tgaagcaact ttatgatcag caggagcagc atatggtata ttgtggtgga gatcttttgg    420

gagaactact gggacgtcag agcttctccg tgaaagaccc aagccctctc tatgatatgc    480

taagaaagaa tcttgtcact ttagccactg ctactacaga tgctgctcag actctcgctc    540

tcgcacagga tcacagtatg gatattccaa gtcaagacca actgaagcaa agtgcagagg    600

aaagttccac ttccagaaaa agaactacag aagacgatat ccccacactg cctacctcag    660

agcataaatg catacattct agagaagatg aagacttaat tgaaaattta gcccaagatg    720

aaacatctag gctggacctt ggatttgagg agtgggatgt agctggcctg ccttggtggt    780

ttttaggaaa cttgagaagc aactatacac ctagaagtaa tggctcaact gatttacaga    840

caaatcagga tgtgggtact gccattgttt cagatactac agatgacttg tggtttttga    900

atgagtcagt atcagagcag ttaggtgttg gaataaaagt tgaagctgct gatactgaac    960

aaacaagtga agaagtaggg aaagtaagtg acaaaaaggt gattgaagtg ggaaaaaatg   1020

atgacctgga ggactctaag tccttaagtg atgataccga tgtagaggtt acctctgagg   1080

atgagtggca gtgtactgaa tgcaagaaat ttaactctcc aagcaagagg tactgttttc   1140

gttgttgggc cttgaggaag gattggtatt cagattgttc aaagttaacc cattctctct   1200

ccacgtctga tatcactgcc atacctgaaa aggaaaatga aggaaatgat gtccctgatt   1260

gtcgaagaac catttcggct cctgtcgtta gacctaaaga tgcgtatata aagaaagaaa   1320

actccaaact ttttgatccc tgcaactcag tggaattctt ggatttggct cacagttctg   1380

aaagccaaga gaccatctca agcatgggag aacagttaga taacctttct gaacagagaa   1440

cagatacaga aaacatggag gattgccaga atctcttgaa gccatgtagc ttatgtgaga   1500

aaagaccacg agacgggaac attattcatg gaaggacggg ccatcttgtc acttgttttc   1560

actgtgccag aagactaaag aaggctgggg cttcatgccc tatttgcaag aaagagattc   1620

agctggttat taaggttttt atagcataat ggtagtacga acataaaaat gcatttattc   1680

cgttcactta ccacattatt tgaaaatcaa tcctttattt aattttattt ccaacctgtc   1740

agagaatgtt cttaggcatc aaaatccaag gtagctgtaa gaaaaatact ggagctaaca   1800

atgaagaaca gaagtaatct gattagtcaa attattaagt gccatggatt actttatgca   1860

gcagtcaggt acatagttag gtgaacccaa aagaaaaact cttgaaaaca agagatttct   1920

tccatgcaca tttacaatat tgaggtataa ttaacatgat aaagtgtttc cttctaacga   1980

gttgtagaaa tctgagtaac cacccaaaaa agcaatagaa tgtttctgtc accccaaaac   2040

actcccttct gcccctcttc agacagtcct tcagctattt catggctctc accctagttt   2100

tttttttttt tgcacttttt tttttccggg ggtatagggg aggtgtgggg cgacagggtc   2160

tgtcttgttc tgtctcccag gctgaagtgc agtgcagtgg tatgatcatg gctcactgca   2220

gccttggttt cctgggcata agtggtcttc ccacttcagc ctcctgagta gctgagacta   2280

tagactagca taaccacact ggctaatttt ttgtggagat gaagtctcac tatgttgccc   2340

aggctggtct cgaactcctg ggctcaaaca atcctcccgc ctcagccttc caaattgctg   2400

ggattatagt catgaggcac ctagtctggc ccttttgcaa gactttaatc tgaaatctaa   2460

atttttaaaa tttaagtact tacaaaggat atactatcca acatattgca tattatatat   2520

gtgctttaaa gttttttttt ttttttgaga gacggtctca ctttgtcatc caagctggag   2580

tgcagtggtg caaacacggc ccacctcctg ggctcaagtg atcctccagc ctcagcttcc   2640

ctcacaggca ttcactatca ctcccagcta attaaaataa ttt                     2683


<210>  1303
<211>  490
<212>  PRT
<213>  Homo sapiens

<400>  1303


Met Thr Ser Phe Ser Thr Ser Ala Gln Cys Ser Thr Ser Asp Ser Ala 
1               5                   10                  15      


Cys Arg Ile Ser Pro Gly Gln Ile Asn Gln Val Arg Pro Lys Leu Pro 
            20                  25                  30          


Leu Leu Lys Ile Leu His Ala Ala Gly Ala Gln Gly Glu Met Phe Thr 
        35                  40                  45              


Val Lys Glu Val Met His Tyr Leu Gly Gln Tyr Ile Met Val Lys Gln 
    50                  55                  60                  


Leu Tyr Asp Gln Gln Glu Gln His Met Val Tyr Cys Gly Gly Asp Leu 
65                  70                  75                  80  


Leu Gly Glu Leu Leu Gly Arg Gln Ser Phe Ser Val Lys Asp Pro Ser 
                85                  90                  95      


Pro Leu Tyr Asp Met Leu Arg Lys Asn Leu Val Thr Leu Ala Thr Ala 
            100                 105                 110         


Thr Thr Asp Ala Ala Gln Thr Leu Ala Leu Ala Gln Asp His Ser Met 
        115                 120                 125             


Asp Ile Pro Ser Gln Asp Gln Leu Lys Gln Ser Ala Glu Glu Ser Ser 
    130                 135                 140                 


Thr Ser Arg Lys Arg Thr Thr Glu Asp Asp Ile Pro Thr Leu Pro Thr 
145                 150                 155                 160 


Ser Glu His Lys Cys Ile His Ser Arg Glu Asp Glu Asp Leu Ile Glu 
                165                 170                 175     


Asn Leu Ala Gln Asp Glu Thr Ser Arg Leu Asp Leu Gly Phe Glu Glu 
            180                 185                 190         


Trp Asp Val Ala Gly Leu Pro Trp Trp Phe Leu Gly Asn Leu Arg Ser 
        195                 200                 205             


Asn Tyr Thr Pro Arg Ser Asn Gly Ser Thr Asp Leu Gln Thr Asn Gln 
    210                 215                 220                 


Asp Val Gly Thr Ala Ile Val Ser Asp Thr Thr Asp Asp Leu Trp Phe 
225                 230                 235                 240 


Leu Asn Glu Ser Val Ser Glu Gln Leu Gly Val Gly Ile Lys Val Glu 
                245                 250                 255     


Ala Ala Asp Thr Glu Gln Thr Ser Glu Glu Val Gly Lys Val Ser Asp 
            260                 265                 270         


Lys Lys Val Ile Glu Val Gly Lys Asn Asp Asp Leu Glu Asp Ser Lys 
        275                 280                 285             


Ser Leu Ser Asp Asp Thr Asp Val Glu Val Thr Ser Glu Asp Glu Trp 
    290                 295                 300                 


Gln Cys Thr Glu Cys Lys Lys Phe Asn Ser Pro Ser Lys Arg Tyr Cys 
305                 310                 315                 320 


Phe Arg Cys Trp Ala Leu Arg Lys Asp Trp Tyr Ser Asp Cys Ser Lys 
                325                 330                 335     


Leu Thr His Ser Leu Ser Thr Ser Asp Ile Thr Ala Ile Pro Glu Lys 
            340                 345                 350         


Glu Asn Glu Gly Asn Asp Val Pro Asp Cys Arg Arg Thr Ile Ser Ala 
        355                 360                 365             


Pro Val Val Arg Pro Lys Asp Ala Tyr Ile Lys Lys Glu Asn Ser Lys 
    370                 375                 380                 


Leu Phe Asp Pro Cys Asn Ser Val Glu Phe Leu Asp Leu Ala His Ser 
385                 390                 395                 400 


Ser Glu Ser Gln Glu Thr Ile Ser Ser Met Gly Glu Gln Leu Asp Asn 
                405                 410                 415     


Leu Ser Glu Gln Arg Thr Asp Thr Glu Asn Met Glu Asp Cys Gln Asn 
            420                 425                 430         


Leu Leu Lys Pro Cys Ser Leu Cys Glu Lys Arg Pro Arg Asp Gly Asn 
        435                 440                 445             


Ile Ile His Gly Arg Thr Gly His Leu Val Thr Cys Phe His Cys Ala 
    450                 455                 460                 


Arg Arg Leu Lys Lys Ala Gly Ala Ser Cys Pro Ile Cys Lys Lys Glu 
465                 470                 475                 480 


Ile Gln Leu Val Ile Lys Val Phe Ile Ala 
                485                 490 

<210>  1304
<211>  3624
<212>  DNA
<213>  Homo sapiens

<400>  1304
gtgtgaggcc gtgtgggagg ccggaagttg cggcttcatt actcgccatt tcaaaatgct     60

gccgaggccc taggatctgt gactgccacc cctcccccca cccgggctcg gcgggggagc    120

gactcatgga gctgccgtaa gttttaccaa cagactgcag tttcttcact accaaaatga    180

catcattttc cacctctgct cagtgttcaa catctgacag tgcttgcagg atctctcctg    240

gacaaatcaa tcaggtacga ccaaaactgc cgcttttgaa gattttgcat gcagcaggtg    300

cgcaaggtga aatgttcact gttaaagagg tcatgcacta tttaggtcag tacataatgg    360

tgaagcaact ttatgatcag caggagcagc atatggtata ttgtggtgga gatcttttgg    420

gagaactact gggacgtcag agcttctccg tgaaagaccc aagccctctc tatgatatgc    480

taagaaagaa tcttgtcact ttagccactg ctactacaga tgctgctcag actctcgctc    540

tcgcacagga tcacagtatg gatattccaa gtcaagacca actgaagcaa agtgcagagg    600

aaagttccac ttccagaaaa agaactacag aagacgatat ccccacactg cctacctcag    660

agcataaatg catacattct agagaagatg aagacttaat tgaaaattta gcccaagatg    720

aaacatctag gctggacctt ggatttgagg agtgggatgt agctggcctg ccttggtggt    780

ttttaggaaa cttgagaagc aactatacac ctagaagtaa tggctcaact gatttacaga    840

caaatcagga tgtgggtact gccattgttt cagatactac agatgacttg tggtttttga    900

atgagtcagt atcagagcag ttaggtgttg gaataaaagt tgaagctgct gatactgaac    960

aaacaagtga agaagtaggg aaagtaagtg acaaaaaggt gattgaagtg ggaaaaaatg   1020

atgacctgga ggactctaag tccttaagtg atgataccga tgtagaggtt acctctgagg   1080

atgagtggca gtgtactgaa tgcaagaaat ttaactctcc aagcaagagg tactgttttc   1140

gttgttgggc cttgaggaag gattggtatt cagattgttc aaagttaacc cattctctct   1200

ccacgtctga tatcactgcc atacctgaaa aggaaaatga aggaaatgat gtccctgatt   1260

gtcgaagaac catttcggct cctgtcgtta gacctaaaga tgcgtatata aagaaagaaa   1320

actccaaact ttttgatccc tgcaactcag tggaattctt ggatttggct cacagttctg   1380

aaagccaaga gaccatctca agcatgggag aacagttaga taacctttct gaacagagaa   1440

cagatacaga aaacatggag gattgccaga atctcttgaa gccatgtagc ttatgtgaga   1500

aaagaccacg agacgggaac attattcatg gaaggacggg ccatcttgtc acttgttttc   1560

actgtgccag aagactaaag aaggctgggg cttcatgccc tatttgcaag aaagagattc   1620

agctggttat taaggttttt atagcataat ggtagtacga acataaaaat gcatttattc   1680

cgttcactta ccacattatt tgaaaatcaa tcctttattt aattttattt ccaacctgtc   1740

agagaatgtt cttaggcatc aaaatccaag gtagctgtaa gaaaaatact ggagctaaca   1800

atgaagaaca gaagtaatct gattagtcaa attattaagt gccatggatt actttatgca   1860

gcagtcaggt acatagttag gtgaacccaa aagaaaaact cttgaaaaca agagatttct   1920

tccatgcaca cttcagctat ttcatggctc tcaccctagt tttttttttt tttgcacttt   1980

tttttttccg ggggtatagg ggaggtgtgg ggccttttgc aagactttaa tctgaaatct   2040

aaatttttaa aatttaagta cttacaaagg atatactatc caacatattg ccacacaaac   2100

atacttctct ggcacagcct tcagaagcat cagttaccct ctttgcgtct taggagtcat   2160

ttagattttt tttgaaggcc ctagaattgt caaacttaag gatcataaaa atcatgaggg   2220

ttgcttgtta aaaatgtcca aacgtgcaga gactgatctt tgagatctgg accaggaatt   2280

tgcatttgaa caagtgttcc tggaatctct atgcaagttt tatacagaac atacttttgg   2340

aatccttgcc ctagaaagtt gtaattttta ataaaactta agaagtaaac attttactta   2400

tgtttatagg tatttgatcc taaatttgac acatcattgc ccatgaaaga atcctcttag   2460

gctgctcagc ttcactcttc ctgcttgccc accggggttt ttcactgctt ctgttagcac   2520

taagtactta gacgatccta agatatgtgc ttgagccgaa tttcatcttt acttgtagga   2580

aactttaaac tatttctaaa ctattttctt ggtctgtttt tgattttctt ttttccttgc   2640

cactgcggta cagatttttt ttactcactg ccactaaact aaagcaaggc atagtttata   2700

tgtgaagtgt tcagagttta ctgctataag gaaacttcca aatactgaca tttacctttt   2760

agctgtagtt attgggacca tgtgctctgg ttttctggag actgccaaat tgctcccatt   2820

tttctgcatc ccacctggtt tctttctgca tgtccccttt cactttcaaa cctcttcatt   2880

tggatgttaa attatatggt cacctagtta taggtaagcc ttgttcgagt tgatatcttg   2940

attgtgagga aggatctgtg tcattggagc ttgtttctgc tgcaacgtgc tgtagactat   3000

gaataatgaa atcacaccac attaccatca gatttcttgt tttagttgtc aaattaatat   3060

ttatgattgt tatcttgggc gaaaagttca gagcagagat gacaaatcat tagaacaacg   3120

atgaatttca gtattacggc taaaaagttc ttctgtctga atattaactc actctccttc   3180

cagtgtactt cacagtaatt ggtatgcttt tttatttaat gcttaaatca aactttataa   3240

aaatcttaga ccagatcttt aatatggtat gccatttccc cagtctacca atggaatagt   3300

atgggtttct aatcctaggc ttgtacaatg gattggagtt gagccatgcc agcctccaca   3360

ctgccactaa cttctgtaat gtaagattga gtcactgcca agcatttgaa atatgcagtt   3420

gtgttttaat tataatttat gtatagttag atgtatgtag tgcattgtgt ggtattattt   3480

ggtttgtaag aatttatttt taagggtcaa ggtcatttgt aacattttgt gtgtgtcaat   3540

tcaatgcaat gttggctgcc ttttgaagtc tttgatatat tggtgaatat tcttctgatc   3600

tataatacaa agctatgtaa tgtt                                          3624


<210>  1305
<211>  490
<212>  PRT
<213>  Homo sapiens

<400>  1305


Met Thr Ser Phe Ser Thr Ser Ala Gln Cys Ser Thr Ser Asp Ser Ala 
1               5                   10                  15      


Cys Arg Ile Ser Pro Gly Gln Ile Asn Gln Val Arg Pro Lys Leu Pro 
            20                  25                  30          


Leu Leu Lys Ile Leu His Ala Ala Gly Ala Gln Gly Glu Met Phe Thr 
        35                  40                  45              


Val Lys Glu Val Met His Tyr Leu Gly Gln Tyr Ile Met Val Lys Gln 
    50                  55                  60                  


Leu Tyr Asp Gln Gln Glu Gln His Met Val Tyr Cys Gly Gly Asp Leu 
65                  70                  75                  80  


Leu Gly Glu Leu Leu Gly Arg Gln Ser Phe Ser Val Lys Asp Pro Ser 
                85                  90                  95      


Pro Leu Tyr Asp Met Leu Arg Lys Asn Leu Val Thr Leu Ala Thr Ala 
            100                 105                 110         


Thr Thr Asp Ala Ala Gln Thr Leu Ala Leu Ala Gln Asp His Ser Met 
        115                 120                 125             


Asp Ile Pro Ser Gln Asp Gln Leu Lys Gln Ser Ala Glu Glu Ser Ser 
    130                 135                 140                 


Thr Ser Arg Lys Arg Thr Thr Glu Asp Asp Ile Pro Thr Leu Pro Thr 
145                 150                 155                 160 


Ser Glu His Lys Cys Ile His Ser Arg Glu Asp Glu Asp Leu Ile Glu 
                165                 170                 175     


Asn Leu Ala Gln Asp Glu Thr Ser Arg Leu Asp Leu Gly Phe Glu Glu 
            180                 185                 190         


Trp Asp Val Ala Gly Leu Pro Trp Trp Phe Leu Gly Asn Leu Arg Ser 
        195                 200                 205             


Asn Tyr Thr Pro Arg Ser Asn Gly Ser Thr Asp Leu Gln Thr Asn Gln 
    210                 215                 220                 


Asp Val Gly Thr Ala Ile Val Ser Asp Thr Thr Asp Asp Leu Trp Phe 
225                 230                 235                 240 


Leu Asn Glu Ser Val Ser Glu Gln Leu Gly Val Gly Ile Lys Val Glu 
                245                 250                 255     


Ala Ala Asp Thr Glu Gln Thr Ser Glu Glu Val Gly Lys Val Ser Asp 
            260                 265                 270         


Lys Lys Val Ile Glu Val Gly Lys Asn Asp Asp Leu Glu Asp Ser Lys 
        275                 280                 285             


Ser Leu Ser Asp Asp Thr Asp Val Glu Val Thr Ser Glu Asp Glu Trp 
    290                 295                 300                 


Gln Cys Thr Glu Cys Lys Lys Phe Asn Ser Pro Ser Lys Arg Tyr Cys 
305                 310                 315                 320 


Phe Arg Cys Trp Ala Leu Arg Lys Asp Trp Tyr Ser Asp Cys Ser Lys 
                325                 330                 335     


Leu Thr His Ser Leu Ser Thr Ser Asp Ile Thr Ala Ile Pro Glu Lys 
            340                 345                 350         


Glu Asn Glu Gly Asn Asp Val Pro Asp Cys Arg Arg Thr Ile Ser Ala 
        355                 360                 365             


Pro Val Val Arg Pro Lys Asp Ala Tyr Ile Lys Lys Glu Asn Ser Lys 
    370                 375                 380                 


Leu Phe Asp Pro Cys Asn Ser Val Glu Phe Leu Asp Leu Ala His Ser 
385                 390                 395                 400 


Ser Glu Ser Gln Glu Thr Ile Ser Ser Met Gly Glu Gln Leu Asp Asn 
                405                 410                 415     


Leu Ser Glu Gln Arg Thr Asp Thr Glu Asn Met Glu Asp Cys Gln Asn 
            420                 425                 430         


Leu Leu Lys Pro Cys Ser Leu Cys Glu Lys Arg Pro Arg Asp Gly Asn 
        435                 440                 445             


Ile Ile His Gly Arg Thr Gly His Leu Val Thr Cys Phe His Cys Ala 
    450                 455                 460                 


Arg Arg Leu Lys Lys Ala Gly Ala Ser Cys Pro Ile Cys Lys Lys Glu 
465                 470                 475                 480 


Ile Gln Leu Val Ile Lys Val Phe Ile Ala 
                485                 490 

<210>  1306
<211>  3557
<212>  DNA
<213>  Homo sapiens

<400>  1306
ggaggccgga agttgcggct tcattactcg ccatttcaaa atgctgccga ggccctagga     60

tctgtgactg ccacccctcc ccccacccgg gctcggcggg ggagcgactc atggagctgc    120

cgtaagtttt accaacagac tgcagtttct tcactaccaa aatgacatca ttttccacct    180

ctgctcagtg ttcaacatct gacagtgctt gcaggatctc tcctggacaa atcaatcagg    240

tacgaccaaa actgccgctt ttgaagattt tgcatgcagc aggtgcgcaa ggtgaaatgt    300

tcactgttaa agaggtcatg cactatttag gtcagtacat aatggtgaag caactttatg    360

atcagcagga gcagcatatg gtatattgtg gtggagatct tttgggagaa ctactgggac    420

gtcagagctt ctccgtgaaa gacccaagcc ctctctatga tatgctaaga aagaatcttg    480

tcactttagc cactgctact acagcaaagt gcagaggaaa gttccacttc cagaaaaaga    540

actacagaag acgatatccc cacactgcct acctcagagc ataaatgcat acattctaga    600

gaagatgaag acttaattga aaatttagcc caagatgaaa catctaggct ggaccttgga    660

tttgaggagt gggatgtagc tggcctgcct tggtggtttt taggaaactt gagaagcaac    720

tatacaccta gaagtaatgg ctcaactgat ttacagacaa atcaggatgt gggtactgcc    780

attgtttcag atactacaga tgacttgtgg tttttgaatg agtcagtatc agagcagtta    840

ggtgttggaa taaaagttga agctgctgat actgaacaaa caagtgaaga agtagggaaa    900

gtaagtgaca aaaaggtgat tgaagtggga aaaaatgatg acctggagga ctctaagtcc    960

ttaagtgatg ataccgatgt agaggttacc tctgaggatg agtggcagtg tactgaatgc   1020

aagaaattta actctccaag caagaggtac tgttttcgtt gttgggcctt gaggaaggat   1080

tggtattcag attgttcaaa gttaacccat tctctctcca cgtctgatat cactgccata   1140

cctgaaaagg aaaatgaagg aaatgatgtc cctgattgtc gaagaaccat ttcggctcct   1200

gtcgttagac ctaaagatgc gtatataaag aaagaaaact ccaaactttt tgatccctgc   1260

aactcagtgg aattcttgga tttggctcac agttctgaaa gccaagagac catctcaagc   1320

atgggagaac agttagataa cctttctgaa cagagaacag atacagaaaa catggaggat   1380

tgccagaatc tcttgaagcc atgtagctta tgtgagaaaa gaccacgaga cgggaacatt   1440

attcatggaa ggacgggcca tcttgtcact tgttttcact gtgccagaag actaaagaag   1500

gctggggctt catgccctat ttgcaagaaa gagattcagc tggatgccaa agaagagtga   1560

atggcccaca aagagcctgg tagcacatac gcttttcaaa aggtcatgca cttacagcta   1620

aagccattaa ggcaggaggg ggctgattga aactgaagaa tagtacagta ggaggagagg   1680

accaggagct gaaaagacag gtcgctatgt tgagagagag agagaggaag aaagatctaa   1740

taggacttca aaggctgtgg tagatgtatt actgtcaaaa cctgcgcagc ttttctctac   1800

caggccttgg aaaagattgc acttcctgca ccactggcag cgggcggctt aggcagatac   1860

tccaatattt ctgacacata catacacgga aaaccttgca agagtggaga aaagaaggga   1920

gaggcagcct cggtgtctgg atgcccagcc taaccaagtc agcttcccat ctttggctga   1980

gacaaggaga accctgctgg gctaggggac ccagatagtg accaggttct gcatgtgatt   2040

tccctgtgga attccaacca aggacagaca gttagcctaa aaacaacagc agaagcagca   2100

gcaacaacga tgcaaactgg gcaggggagg cccgagaagg agagggtggc accgtcattc   2160

tcactttcca gctgaggaca cggatggttt ctataacagt gaatttgcaa atagttggaa   2220

cctctgaagt gcttcctctc ctggactgga aaccccttga ggatgtgtac ggcacccgca   2280

tcccctccat ctgcacccgc agccacagcc acagccacag ccagcgctat gtcccgttgc   2340

cattcacatt catacctgca acgtacactc atacatgtgt cggatatttg cgaagaagct   2400

ccctttccca cctaggtaaa tgctagcttc cagaaatttg aaaaaaaatg agtgtaattc   2460

ctactgggtt ggttcccagc aggcctttgt ctttccttct ccctcctcca ggcccctctt   2520

ctttcctttc ctttcctttc cctcctctac ctctttccct tcctattctt ctgctcctcc   2580

tccctcccag ctggttccct atttccctta ccccctcaaa catctcccct ctctccatcc   2640

ccactcccaa tctgccaaac ccacccccac ctaaaaatgt ggaccgtgga gtctctgacc   2700

gaggtttcct ttcccaacat ggggagcccg ggctggctgc gatttgttgg ggacagagga   2760

cagcactgga tttgactcat ccctgcatcc cccgagcacc tcgtgggtgc cgtaaaggca   2820

gctgggttga tgatgactga gtgaaggagc gcctgagtgg atgagccact gagtgaatga   2880

actggagttc atcttccacg tggtcctcag catccactct agaagccaaa gccaagcctg   2940

agggatctaa agccttggga cttctggatc tgcaagtggt ccctgttttg gtagctattg   3000

actgacgagg ggctcttcgt cggccaaaaa gaaggctcct accgtggctg tttgctgatg   3060

gtcttcgcag agcctgctgt ctttgagctt cctgagagag ggacactacc ctcgcttagt   3120

ggctttatgc tcttgcagta ctcatgcttc ctactgtcac agttctgacc acaccgtggg   3180

aaaacgtctc taactagaga cctgtcttgc ctcttgtgcc tgtagtacgg gatgggtgcc   3240

cagtgtgtgt tgattgtatg aatcaatctc tgtgactcca gagttccttt cttcaggaga   3300

ttagacatca cccctgcaat caacaatgca agccactgct gtttcctcca tcctgagcat   3360

gaggaaccta tccagtttct ctctcagatg ccagggccat gaggcaagtc cagccttggc   3420

ctagaaccaa agatggaaac aaaaaggggc cagactgtgt tgccttcttg agcctggtct   3480

gactcctgag tggaagtctg attccaggta tccagggggc tgtgtgccgt ttacacttca   3540

catctgtgct gccaggt                                                  3557


<210>  1307
<211>  140
<212>  PRT
<213>  Homo sapiens

<400>  1307


Met Thr Ser Phe Ser Thr Ser Ala Gln Cys Ser Thr Ser Asp Ser Ala 
1               5                   10                  15      


Cys Arg Ile Ser Pro Gly Gln Ile Asn Gln Val Arg Pro Lys Leu Pro 
            20                  25                  30          


Leu Leu Lys Ile Leu His Ala Ala Gly Ala Gln Gly Glu Met Phe Thr 
        35                  40                  45              


Val Lys Glu Val Met His Tyr Leu Gly Gln Tyr Ile Met Val Lys Gln 
    50                  55                  60                  


Leu Tyr Asp Gln Gln Glu Gln His Met Val Tyr Cys Gly Gly Asp Leu 
65                  70                  75                  80  


Leu Gly Glu Leu Leu Gly Arg Gln Ser Phe Ser Val Lys Asp Pro Ser 
                85                  90                  95      


Pro Leu Tyr Asp Met Leu Arg Lys Asn Leu Val Thr Leu Ala Thr Ala 
            100                 105                 110         


Thr Thr Ala Lys Cys Arg Gly Lys Phe His Phe Gln Lys Lys Asn Tyr 
        115                 120                 125             


Arg Arg Arg Tyr Pro His Thr Ala Tyr Leu Arg Ala 
    130                 135                 140 

<210>  1308
<211>  896
<212>  DNA
<213>  Homo sapiens

<400>  1308
gaggccggaa gttgcggctt cattactcgc catttcaaaa tgctgccgag gccctaggat     60

ctgtgactgc cacccctccc cccacccggg ctcggcgggg gagcgactca tggagctgcc    120

gtaagtttta ccaacagact gcagtttctt cactaccaaa atgacatcat tttccacctc    180

tgctcagtgt tcaacatctg acagtgcttg caggatctct cctggacaaa tcaatcaggt    240

acgaccaaaa ctgccgcttt tgaagatttt gcatgcagca ggtgcgcaag gtgaaatgtt    300

cactgttaaa gaggtcatgc actatttagg tcagtacata atggtgaagc aactttatga    360

tcagcaggag cagcatatgg tatattgtgg tggagatctt ttgggagaac tactgggacg    420

tcagagcttc tccgtgaaag acccaagccc tctctatgat atgctaagaa agaatcttgt    480

cactttagcc actgctacta caggtatgtc acatcatatt tcttcagtct gtatcacagc    540

tttgagttca agggggcaaa tgatgggaaa acaaagaaga tgaaggtgga aatggaatgc    600

tatctttggc atgactggga gaaatacata ctacctgtca cacagaatgt tatgttatta    660

actttttact gaaaaatcaa acatagagta gaaggatttc cactttctag acgtactgtt    720

aacgttttgt catattgctt catctagaca cacttttaaa aatctctagc agataaggac    780

ttttttctcc aaacattcaa tatcattatt acacataaca aatttaacat gtaattccat    840

aatcctattt catagccagt ttatgtatca tttcccccag ttatctcaaa aatacc        896


<210>  1309
<211>  140
<212>  PRT
<213>  Homo sapiens

<400>  1309


Met Thr Ser Phe Ser Thr Ser Ala Gln Cys Ser Thr Ser Asp Ser Ala 
1               5                   10                  15      


Cys Arg Ile Ser Pro Gly Gln Ile Asn Gln Val Arg Pro Lys Leu Pro 
            20                  25                  30          


Leu Leu Lys Ile Leu His Ala Ala Gly Ala Gln Gly Glu Met Phe Thr 
        35                  40                  45              


Val Lys Glu Val Met His Tyr Leu Gly Gln Tyr Ile Met Val Lys Gln 
    50                  55                  60                  


Leu Tyr Asp Gln Gln Glu Gln His Met Val Tyr Cys Gly Gly Asp Leu 
65                  70                  75                  80  


Leu Gly Glu Leu Leu Gly Arg Gln Ser Phe Ser Val Lys Asp Pro Ser 
                85                  90                  95      


Pro Leu Tyr Asp Met Leu Arg Lys Asn Leu Val Thr Leu Ala Thr Ala 
            100                 105                 110         


Thr Thr Gly Met Ser His His Ile Ser Ser Val Cys Ile Thr Ala Leu 
        115                 120                 125             


Ser Ser Arg Gly Gln Met Met Gly Lys Gln Arg Arg 
    130                 135                 140 

<210>  1310
<211>  591
<212>  DNA
<213>  Homo sapiens

<400>  1310
gaggccggaa gttgcggctt cattactcgc catttcaaaa tgctgccgag gccctaggat     60

ctgtgactgc cacccctccc cccacccggg ctcggcgggg gagcgactca tggagctgcc    120

gtaagtttta ccaacagact gcagtttctt cactaccaaa atgacatcat tttccacctc    180

tgctcagtgt tcaacatctg acagtgcttg caggatctct cctggacaaa tcaatcaggt    240

acgaccaaaa ctgccgcttt tgaagatttt gcatgcagca ggtgcgcaag gtgaaatgtt    300

cactgttaaa gaggtcatgc actatttagg tcagtacata atggtgaagc aactttatga    360

tcagcaggag cagcatatgg tatattgtgg tggagatctt ttgggagaac tactgggacg    420

tcagagcttc tccgtgaaag acccaagccc tctctatgat atgctaagaa agaatcttgt    480

cactttagcc actgctacta caggctagag tgcagtggca agatctcggc tcactgcaac    540

ctccgcctcc gtggcacaag cagtcctccc acctcagcct cctcagtagc t             591


<210>  1311
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  1311


Met Thr Ser Phe Ser Thr Ser Ala Gln Cys Ser Thr Ser Asp Ser Ala 
1               5                   10                  15      


Cys Arg Ile Ser Pro Gly Gln Ile Asn Gln Val Arg Pro Lys Leu Pro 
            20                  25                  30          


Leu Leu Lys Ile Leu His Ala Ala Gly Ala Gln Gly Glu Met Phe Thr 
        35                  40                  45              


Val Lys Glu Val Met His Tyr Leu Gly Gln Tyr Ile Met Val Lys Gln 
    50                  55                  60                  


Leu Tyr Asp Gln Gln Glu Gln His Met Val Tyr Cys Gly Gly Asp Leu 
65                  70                  75                  80  


Leu Gly Glu Leu Leu Gly Arg Gln Ser Phe Ser Val Lys Asp Pro Ser 
                85                  90                  95      


Pro Leu Tyr Asp Met Leu Arg Lys Asn Leu Val Thr Leu Ala Thr Ala 
            100                 105                 110         


Thr Thr Gly 
        115 

<210>  1312
<211>  2599
<212>  DNA
<213>  Homo sapiens

<400>  1312
gaggccggaa gttgcggctt cattactcgc catttcaaaa tgctgccgag gccctaggat     60

ctgtgactgc cacccctccc cccacccggg ctcggcgggg gagcgactca tggagctgcc    120

gtaagtttta ccaacagact gcagtttctt cactaccaaa atgacatcat tttccacctc    180

tgctcagtgt tcaacatctg acagtgcttg caggatctct cctggacaaa tcaatcaggt    240

acgaccaaaa ctgccgcttt tgaagatttt gcatgcagca ggtgcgcaag gtgaaatgtt    300

cactgttaaa gaggtcatgc actatttagg tcagtacata atggtgaagc aactttatga    360

tcagcaggag cagcatatgg tatattgtgg tggagatctt ttgggagaac tactgggacg    420

tcagagcttc tccgtgaaag acccaagccc tctctatgat atgctaagaa agaatcttgt    480

cactttagcc actgctacta cagcaaagtg cagaggaaag ttccacttcc agaaaaagaa    540

ctacagaaga cgatatcccc acactgccta cctcagagca taaatgcata cattctagag    600

aagatgaaga cttaattgaa aatttagccc aagatgaaac atctaggctg gaccttggat    660

ttgaggagtg ggatgtagct ggcctgcctt ggtggttttt aggaaacttg agaagcaact    720

atacacctag aagtaatggc tcaactgatt tacagacaaa tcaggatgtg ggtactgcca    780

ttgtttcaga tactacagat gacttgtggt ttttgaatga gtcagtatca gagcagttag    840

gtgttggaat aaaagttgaa gctgctgata ctgaacaaac aagtgaagaa gtagggaaag    900

taagtgacaa aaaggtgatt gaagtgggaa aaaatgatga cctggaggac tctaagtcct    960

taagtgatga taccgatgta gaggttacct ctgaggatga gtggcagtgt actgaatgca   1020

agaaatttaa ctctccaagc aagaggtact gttttcgttg ttgggccttg aggaaggatt   1080

ggtattcaga ttgttcaaag ttaacccatt ctctctccac gtctgatatc actgccatac   1140

ctgaaaagga aaatgaagga aatgatgtcc ctgattgtcg aagaaccatt tcggctcctg   1200

tcgttagacc taaagatgcg tatataaaga aagaaaactc caaacttttt gatccctgca   1260

actcagtgga attcttggat ttggctcaca gttctgaaag ccaagagacc atctcaagca   1320

tgggagaaca gttagataac ctttctgaac agagaacaga tacagaaaac atggaggatt   1380

gccagaatct cttgaagcca tgtagcttat gtgagaaaag accacgagac gggaacatta   1440

ttcatggaag gacgggccat cttgtcactt gttttcactg tgccagaaga ctaaagaagg   1500

ctggggcttc atgccctatt tgcaagaaag agattcagct ggttattaag gtttttatag   1560

cataatggta gtacgaacat aaaaatgcat ttattccgtt cacttaccac attatttgaa   1620

aatcaatcct ttatttaatt ttatttccaa cctgtcagag aatgttctta ggcatcaaaa   1680

tccaaggtag ctgtaagaaa aatactggag ctaacaatga agaacagaag taatctgatt   1740

agtcaaatta ttaagtgcca tggattactt tatgcagcag tcaggtacat agttaggtga   1800

acccaaaaga aaaactcttg aaaacaagag atttcttcca tgcacattta caatattgag   1860

gtataattaa catgataaag tgtttccttc taacgagttg tagaaatctg agtaaccacc   1920

caaaaaagca atagaatgtt tctgtcaccc caaaacactc ccttctgccc ctcttcagac   1980

agtccttcag ctatttcatg gctctcaccc tagttttttt tttttttgca cttttttttt   2040

tccgggggta taggggaggt gtggggcgac agggtctgtc ttgttctgtc tcccaggctg   2100

aagtgcagtg cagtggtatg atcatggctc actgcagcct tggtttcctg ggcataagtg   2160

gtcttcccac ttcagcctcc tgagtagctg agactataga ctagcataac cacactggct   2220

aattttttgt ggagatgaag tctcactatg ttgcccaggc tggtctcgaa ctcctgggct   2280

caaacaatcc tcccgcctca gccttccaaa ttgctgggat tatagtcatg aggcacctag   2340

tctggccctt ttgcaagact ttaatctgaa atctaaattt ttaaaattta agtacttaca   2400

aaggatatac tatccaacat attgcatatt atatatgtgc tttaaagttt tttttttttt   2460

ttgagagacg gtctcacttt gtcatccaag ctggagtgca gtggtgcaaa cacggcccac   2520

ctcctgggct caagtgatcc tccagcctca gcttccctca caggcattca ctatcactcc   2580

cagctaatta aaataattt                                                2599


<210>  1313
<211>  140
<212>  PRT
<213>  Homo sapiens

<400>  1313


Met Thr Ser Phe Ser Thr Ser Ala Gln Cys Ser Thr Ser Asp Ser Ala 
1               5                   10                  15      


Cys Arg Ile Ser Pro Gly Gln Ile Asn Gln Val Arg Pro Lys Leu Pro 
            20                  25                  30          


Leu Leu Lys Ile Leu His Ala Ala Gly Ala Gln Gly Glu Met Phe Thr 
        35                  40                  45              


Val Lys Glu Val Met His Tyr Leu Gly Gln Tyr Ile Met Val Lys Gln 
    50                  55                  60                  


Leu Tyr Asp Gln Gln Glu Gln His Met Val Tyr Cys Gly Gly Asp Leu 
65                  70                  75                  80  


Leu Gly Glu Leu Leu Gly Arg Gln Ser Phe Ser Val Lys Asp Pro Ser 
                85                  90                  95      


Pro Leu Tyr Asp Met Leu Arg Lys Asn Leu Val Thr Leu Ala Thr Ala 
            100                 105                 110         


Thr Thr Ala Lys Cys Arg Gly Lys Phe His Phe Gln Lys Lys Asn Tyr 
        115                 120                 125             


Arg Arg Arg Tyr Pro His Thr Ala Tyr Leu Arg Ala 
    130                 135                 140 

<210>  1314
<211>  901
<212>  DNA
<213>  Homo sapiens

<400>  1314
agttggaggt tggagcgtgc ctgaaactgt tactgtttca gccttcacct gagagaagct     60

tggacgattc ttactcttaa ttaaatcaga actagaaagt agtcagaaga tatgcagaac    120

ctcagcaagg ttttaccaac agactgcagt ttcttcacta ccaaaatgac atcattttcc    180

acctctgctc agtgttcaac atctgacagt gcttgcagga tctctcctgg acaaatcaat    240

caggtacgac caaaactgcc gcttttgaag attttgcatg cagcaggtgc gcaaggtgaa    300

atgttcactg ttaaagaggt catgcactat ttaggtcagt acataatggt gaagcaactt    360

tatgatcagc aggagcagca tatggtatat tgtggtggag atcttttggg agaactactg    420

ggacgtcaga gcttctccgt gaaagaccca agccctctct atgatatgct aagaaagaat    480

cttgtcactt tagccactgc tactacaggt atgtcacatc atatttcttc agtctgtatc    540

acagctttga gttcaagggg gcaaatgatg ggaaaacaaa gaagatgaag gtggaaatgg    600

aatgctatct ttggcatgac tgggagaaat acatactacc tgtcacacag aatgttatgt    660

tattaacttt ttactgaaaa atcaaacata gagtagaagg atttccactt tctagacgta    720

ctgttaacgt tttgtcatat tgcttcatct agacacactt ttaaaaatct ctagcagata    780

aggacttttt tctccaaaca ttcaatatca ttattacaca taacaaattt aacatgtaat    840

tccataatcc tatttcatag ccagtttatg tatcatttcc cccagttatc tcaaaaatac    900

c                                                                    901


<210>  1315
<211>  158
<212>  PRT
<213>  Homo sapiens

<400>  1315


Met Gln Asn Leu Ser Lys Val Leu Pro Thr Asp Cys Ser Phe Phe Thr 
1               5                   10                  15      


Thr Lys Met Thr Ser Phe Ser Thr Ser Ala Gln Cys Ser Thr Ser Asp 
            20                  25                  30          


Ser Ala Cys Arg Ile Ser Pro Gly Gln Ile Asn Gln Val Arg Pro Lys 
        35                  40                  45              


Leu Pro Leu Leu Lys Ile Leu His Ala Ala Gly Ala Gln Gly Glu Met 
    50                  55                  60                  


Phe Thr Val Lys Glu Val Met His Tyr Leu Gly Gln Tyr Ile Met Val 
65                  70                  75                  80  


Lys Gln Leu Tyr Asp Gln Gln Glu Gln His Met Val Tyr Cys Gly Gly 
                85                  90                  95      


Asp Leu Leu Gly Glu Leu Leu Gly Arg Gln Ser Phe Ser Val Lys Asp 
            100                 105                 110         


Pro Ser Pro Leu Tyr Asp Met Leu Arg Lys Asn Leu Val Thr Leu Ala 
        115                 120                 125             


Thr Ala Thr Thr Gly Met Ser His His Ile Ser Ser Val Cys Ile Thr 
    130                 135                 140                 


Ala Leu Ser Ser Arg Gly Gln Met Met Gly Lys Gln Arg Arg 
145                 150                 155             

<210>  1316
<211>  1566
<212>  DNA
<213>  Homo sapiens

<400>  1316
agttttacca acagactgca gtttcttcac taccaaaatg acatcatttt ccacctctgc     60

tcagtgttca acatctgaca gtgcttgcag gatctctcct ggacaaatca atcaggaaaa    120

tgaaggaaat gatgtccctg attgtcgaag aaccatttcg gctcctgtcg ttagacctaa    180

agatgcgtat ataaagaaag aaaactccaa actttttgat ccctgcaact cagtggaatt    240

cttggatttg gctcacagtt ctgaaagcca agagaccatc tcaagcatgg gagaacagtt    300

agataacctt tctgaacaga gaacagatac agaaaacatg gaggattgcc agaatctctt    360

gaagccatgt agcttatgtg agaaaagacc acgagacggg aacattattc atggaaggac    420

gggccatctt gtcacttgtt ttcactgtgc cagaagacta aagaaggctg gggcttcatg    480

ccctatttgc aagaaagaga ttcagctggt tattaaggtt tttatagcat aatggtagta    540

cgaacataaa aatgcattta ttccgttcac ttaccacatt atttgaaaat caatccttta    600

tttaatttta tttccaacct gtcagagaat gttcttaggc atcaaaatcc aaggtagctg    660

taagaaaaat actggagcta acaatgaaga acagaagtaa tctgattagt caaattatta    720

agtgccatgg attactttat gcagcagtca ggtacatagt taggtgaacc caaaagaaaa    780

actcttgaaa acaagagatt tcttccatgc acatttacaa tattgaggta taattaacat    840

gataaagtgt ttccttctaa cgagttgtag aaatctgagt aaccacccaa aaaagcaata    900

gaatgtttct gtcaccccaa aacactccct tctgcccctc ttcagacagt ccttcagcta    960

tttcatggct ctcaccctag tttttttttt ttttgcactt ttttttttcc gggggtatag   1020

gggaggtgtg gggcgacagg gtctgtcttg ttctgtctcc caggctgaag tgcagtgcag   1080

tggtatgatc atggctcact gcagccttgg tttcctgggc ataagtggtc ttcccacttc   1140

agcctcctga gtagctgaga ctatagacta gcataaccac actggctaat tttttgtgga   1200

gatgaagtct cactatgttg cccaggctgg tctcgaactc ctgggctcaa acaatcctcc   1260

cgcctcagcc ttccaaattg ctgggattat agtcatgagg cacctagtct ggcccttttg   1320

caagacttta atctgaaatc taaattttta aaatttaagt acttacaaag gatatactat   1380

ccaacatatt gcatattata tatgtgcttt aaagtttttt tttttttttg agagacggtc   1440

tcactttgtc atccaagctg gagtgcagtg gtgcaaacac ggcccacctc ctgggctcaa   1500

gtgatcctcc agcctcagct tccctcacag gcattcacta tcactcccag ctaattaaaa   1560

taattt                                                              1566


<210>  1317
<211>  164
<212>  PRT
<213>  Homo sapiens

<400>  1317


Met Thr Ser Phe Ser Thr Ser Ala Gln Cys Ser Thr Ser Asp Ser Ala 
1               5                   10                  15      


Cys Arg Ile Ser Pro Gly Gln Ile Asn Gln Glu Asn Glu Gly Asn Asp 
            20                  25                  30          


Val Pro Asp Cys Arg Arg Thr Ile Ser Ala Pro Val Val Arg Pro Lys 
        35                  40                  45              


Asp Ala Tyr Ile Lys Lys Glu Asn Ser Lys Leu Phe Asp Pro Cys Asn 
    50                  55                  60                  


Ser Val Glu Phe Leu Asp Leu Ala His Ser Ser Glu Ser Gln Glu Thr 
65                  70                  75                  80  


Ile Ser Ser Met Gly Glu Gln Leu Asp Asn Leu Ser Glu Gln Arg Thr 
                85                  90                  95      


Asp Thr Glu Asn Met Glu Asp Cys Gln Asn Leu Leu Lys Pro Cys Ser 
            100                 105                 110         


Leu Cys Glu Lys Arg Pro Arg Asp Gly Asn Ile Ile His Gly Arg Thr 
        115                 120                 125             


Gly His Leu Val Thr Cys Phe His Cys Ala Arg Arg Leu Lys Lys Ala 
    130                 135                 140                 


Gly Ala Ser Cys Pro Ile Cys Lys Lys Glu Ile Gln Leu Val Ile Lys 
145                 150                 155                 160 


Val Phe Ile Ala 
                

<210>  1318
<211>  2676
<212>  DNA
<213>  Homo sapiens

<400>  1318
agaccaggga cagagtgaac cttctctgtt ctgcccataa cagagttcca gtctctgaac     60

ctttctttgg gatgtagcac ttctgatctt cagttcttcc agttgcattt ttctttgggt    120

ttgtgtgtac ctgtgtgtgt gtgtttgagg atattgcttt attagatttt aataggcgtg    180

ttgcagttaa gttcatgtca ggccatttcc taaagcttcc ccaaacctgg ggaaacttta    240

tagtcatctt ggtacgtggc gagggtttca tatgttttct gaattatgcc taattttgta    300

gtagactgga gggtttatac agatagcctg tttttaacag tagattttgg cctttgtgca    360

gaggtttttt ttccccccag gtttgggatt cttctagctt tgctcacagt gggttgagga    420

gaggtgttgc ctttatttga tgactgttgt gaacttgagt tctctttctt gtgtgtaacc    480

cattgtgttg cacactaact ggtgagccag aatggaactg ctacatcccc tggtctcagt    540

tatttctact gcactgatgg acacctttcc cttctttcag caaagtgcag aggaaagttc    600

cacttccaga aaaagaacta cagaagacga tatccccaca ctgcctacct cagagcataa    660

atgcatacat tctagagaag atgaagactt aattgaaaat ttagcccaag atgaaacatc    720

taggctggac cttggatttg aggagtggga tgtagctggc ctgccttggt ggtttttagg    780

aaacttgaga agcaactata cacctagaag taatggctca actgatttac agacaaatca    840

ggatgtgggt actgccattg tttcagatac tacagatgac ttgtggtttt tgaatgagtc    900

agtatcagag cagttaggtg ttggaataaa agttgaagct gctgatactg aacaaacaag    960

tgaagaagta gggaaagtaa gtgacaaaaa ggtgattgaa gtgggaaaaa atgatgacct   1020

ggaggactct aagtccttaa gtgatgatac cgatgtagag gttacctctg aggatgagtg   1080

gcagtgtact gaatgcaaga aatttaactc tccaagcaag aggtactgtt ttcgttgttg   1140

ggccttgagg aaggattggt attcagattg ttcaaagtta acccattctc tctccacgtc   1200

tgatatcact gccatacctg aaaaggaaaa tgaaggaaat gatgtccctg attgtcgaag   1260

aaccatttcg gctcctgtcg ttagacctaa agatgcgtat ataaagaaag aaaactccaa   1320

actttttgat ccctgcaact cagtggaatt cttggatttg gctcacagtt ctgaaagcca   1380

agagaccatc tcaagcatgg gagaacagtt agataacctt tctgaacaga gaacagatac   1440

agaaaacatg gaggattgcc agaatctctt gaagccatgt agcttatgtg agaaaagacc   1500

acgagacggg aacattattc atggaaggac gggccatctt gtcacttgtt ttcactgtgc   1560

cagaagacta aagaaggctg gggcttcatg ccctatttgc aagaaagaga ttcagctggt   1620

tattaaggtt tttatagcat aatggtagta cgaacataaa aatgcattta ttccgttcac   1680

ttaccacatt atttgaaaat caatccttta tttaatttta tttccaacct gtcagagaat   1740

gttcttaggc atcaaaatcc aaggtagctg taagaaaaat actggagcta acaatgaaga   1800

acagaagtaa tctgattagt caaattatta agtgccatgg attactttat gcagcagtca   1860

ggtacatagt taggtgaacc caaaagaaaa actcttgaaa acaagagatt tcttccatgc   1920

acatttacaa tattgaggta taattaacat gataaagtgt ttccttctaa cgagttgtag   1980

aaatctgagt aaccacccaa aaaagcaata gaatgtttct gtcaccccaa aacactccct   2040

tctgcccctc ttcagacagt ccttcagcta tttcatggct ctcaccctag tttttttttt   2100

ttttgcactt ttttttttcc gggggtatag gggaggtgtg gggcgacagg gtctgtcttg   2160

ttctgtctcc caggctgaag tgcagtgcag tggtatgatc atggctcact gcagccttgg   2220

tttcctgggc ataagtggtc ttcccacttc agcctcctga gtagctgaga ctatagacta   2280

gcataaccac actggctaat tttttgtgga gatgaagtct cactatgttg cccaggctgg   2340

tctcgaactc ctgggctcaa acaatcctcc cgcctcagcc ttccaaattg ctgggattat   2400

agtcatgagg cacctagtct ggcccttttg caagacttta atctgaaatc taaattttta   2460

aaatttaagt acttacaaag gatatactat ccaacatatt gcatattata tatgtgcttt   2520

aaagtttttt tttttttttg agagacggtc tcactttgtc atccaagctg gagtgcagtg   2580

gtgcaaacac ggcccacctc ctgggctcaa gtgatcctcc agcctcagct tccctcacag   2640

gcattcacta tcactcccag ctaattaaaa taattt                             2676


<210>  1319
<211>  376
<212>  PRT
<213>  Homo sapiens

<400>  1319


Met Glu Leu Leu His Pro Leu Val Ser Val Ile Ser Thr Ala Leu Met 
1               5                   10                  15      


Asp Thr Phe Pro Phe Phe Gln Gln Ser Ala Glu Glu Ser Ser Thr Ser 
            20                  25                  30          


Arg Lys Arg Thr Thr Glu Asp Asp Ile Pro Thr Leu Pro Thr Ser Glu 
        35                  40                  45              


His Lys Cys Ile His Ser Arg Glu Asp Glu Asp Leu Ile Glu Asn Leu 
    50                  55                  60                  


Ala Gln Asp Glu Thr Ser Arg Leu Asp Leu Gly Phe Glu Glu Trp Asp 
65                  70                  75                  80  


Val Ala Gly Leu Pro Trp Trp Phe Leu Gly Asn Leu Arg Ser Asn Tyr 
                85                  90                  95      


Thr Pro Arg Ser Asn Gly Ser Thr Asp Leu Gln Thr Asn Gln Asp Val 
            100                 105                 110         


Gly Thr Ala Ile Val Ser Asp Thr Thr Asp Asp Leu Trp Phe Leu Asn 
        115                 120                 125             


Glu Ser Val Ser Glu Gln Leu Gly Val Gly Ile Lys Val Glu Ala Ala 
    130                 135                 140                 


Asp Thr Glu Gln Thr Ser Glu Glu Val Gly Lys Val Ser Asp Lys Lys 
145                 150                 155                 160 


Val Ile Glu Val Gly Lys Asn Asp Asp Leu Glu Asp Ser Lys Ser Leu 
                165                 170                 175     


Ser Asp Asp Thr Asp Val Glu Val Thr Ser Glu Asp Glu Trp Gln Cys 
            180                 185                 190         


Thr Glu Cys Lys Lys Phe Asn Ser Pro Ser Lys Arg Tyr Cys Phe Arg 
        195                 200                 205             


Cys Trp Ala Leu Arg Lys Asp Trp Tyr Ser Asp Cys Ser Lys Leu Thr 
    210                 215                 220                 


His Ser Leu Ser Thr Ser Asp Ile Thr Ala Ile Pro Glu Lys Glu Asn 
225                 230                 235                 240 


Glu Gly Asn Asp Val Pro Asp Cys Arg Arg Thr Ile Ser Ala Pro Val 
                245                 250                 255     


Val Arg Pro Lys Asp Ala Tyr Ile Lys Lys Glu Asn Ser Lys Leu Phe 
            260                 265                 270         


Asp Pro Cys Asn Ser Val Glu Phe Leu Asp Leu Ala His Ser Ser Glu 
        275                 280                 285             


Ser Gln Glu Thr Ile Ser Ser Met Gly Glu Gln Leu Asp Asn Leu Ser 
    290                 295                 300                 


Glu Gln Arg Thr Asp Thr Glu Asn Met Glu Asp Cys Gln Asn Leu Leu 
305                 310                 315                 320 


Lys Pro Cys Ser Leu Cys Glu Lys Arg Pro Arg Asp Gly Asn Ile Ile 
                325                 330                 335     


His Gly Arg Thr Gly His Leu Val Thr Cys Phe His Cys Ala Arg Arg 
            340                 345                 350         


Leu Lys Lys Ala Gly Ala Ser Cys Pro Ile Cys Lys Lys Glu Ile Gln 
        355                 360                 365             


Leu Val Ile Lys Val Phe Ile Ala 
    370                 375     

<210>  1320
<211>  2219
<212>  DNA
<213>  Homo sapiens

<400>  1320
ggggaaactt tatagtcatc ttggtacgtg gcgagggttt catatgtttt ctgaattatg     60

cctaattttg tagtagactg gagggtttat acagatagcc tgtttttaac agtagatttt    120

ggcctttgtg cagaggaaag ttccacttcc agaaaaagaa ctacagaaga cgatatcccc    180

acactgccta cctcagagca taaatgcata cattctagag aagatgaaga cttaattgaa    240

aatttagccc aagatgaaac atctaggctg gaccttggat ttgaggagtg ggatgtagct    300

ggcctgcctt ggtggttttt aggaaacttg agaagcaact atacacctag aagtaatggc    360

tcaactgatt tacagacaaa tcaggatgtg ggtactgcca ttgtttcaga tactacagat    420

gacttgtggt ttttgaatga gtcagtatca gagcagttag gtgttggaat aaaagttgaa    480

gctgctgata ctgaacaaac aagtgaagaa gtagggaaag taagtgacaa aaaggtgatt    540

gaagtgggaa aaaatgatga cctggaggac tctaagtcct taagtgatga taccgatgta    600

gaggttacct ctgaggatga gtggcagtgt actgaatgca agaaatttaa ctctccaagc    660

aagaggtact gttttcgttg ttgggccttg aggaaggatt ggtattcaga ttgttcaaag    720

ttaacccatt ctctctccac gtctgatatc actgccatac ctgaaaagga aaatgaagga    780

aatgatgtcc ctgattgtcg aagaaccatt tcggctcctg tcgttagacc taaagatgcg    840

tatataaaga aagaaaactc caaacttttt gatccctgca actcagtgga attcttggat    900

ttggctcaca gttctgaaag ccaagagacc atctcaagca tgggagaaca gttagataac    960

ctttctgaac agagaacaga tacagaaaac atggaggatt gccagaatct cttgaagcca   1020

tgtagcttat gtgagaaaag accacgagac gggaacatta ttcatggaag gacgggccat   1080

cttgtcactt gttttcactg tgccagaaga ctaaagaagg ctggggcttc atgccctatt   1140

tgcaagaaag agattcagct ggttattaag gtttttatag cataatggta gtacgaacat   1200

aaaaatgcat ttattccgtt cacttaccac attatttgaa aatcaatcct ttatttaatt   1260

ttatttccaa cctgtcagag aatgttctta ggcatcaaaa tccaaggtag ctgtaagaaa   1320

aatactggag ctaacaatga agaacagaag taatctgatt agtcaaatta ttaagtgcca   1380

tggattactt tatgcagcag tcaggtacat agttaggtga acccaaaaga aaaactcttg   1440

aaaacaagag atttcttcca tgcacattta caatattgag gtataattaa catgataaag   1500

tgtttccttc taacgagttg tagaaatctg agtaaccacc caaaaaagca atagaatgtt   1560

tctgtcaccc caaaacactc ccttctgccc ctcttcagac agtccttcag ctatttcatg   1620

gctctcaccc tagttttttt tttttttgca cttttttttt tccgggggta taggggaggt   1680

gtggggcgac agggtctgtc ttgttctgtc tcccaggctg aagtgcagtg cagtggtatg   1740

atcatggctc actgcagcct tggtttcctg ggcataagtg gtcttcccac ttcagcctcc   1800

tgagtagctg agactataga ctagcataac cacactggct aattttttgt ggagatgaag   1860

tctcactatg ttgcccaggc tggtctcgaa ctcctgggct caaacaatcc tcccgcctca   1920

gccttccaaa ttgctgggat tatagtcatg aggcacctag tctggccctt ttgcaagact   1980

ttaatctgaa atctaaattt ttaaaattta agtacttaca aaggatatac tatccaacat   2040

attgcatatt atatatgtgc tttaaagttt tttttttttt ttgagagacg gtctcacttt   2100

gtcatccaag ctggagtgca gtggtgcaaa cacggcccac ctcctgggct caagtgatcc   2160

tccagcctca gcttccctca caggcattca ctatcactcc cagctaatta aaataattt    2219


<210>  1321
<211>  375
<212>  PRT
<213>  Homo sapiens

<400>  1321


Met Pro Asn Phe Val Val Asp Trp Arg Val Tyr Thr Asp Ser Leu Phe 
1               5                   10                  15      


Leu Thr Val Asp Phe Gly Leu Cys Ala Glu Glu Ser Ser Thr Ser Arg 
            20                  25                  30          


Lys Arg Thr Thr Glu Asp Asp Ile Pro Thr Leu Pro Thr Ser Glu His 
        35                  40                  45              


Lys Cys Ile His Ser Arg Glu Asp Glu Asp Leu Ile Glu Asn Leu Ala 
    50                  55                  60                  


Gln Asp Glu Thr Ser Arg Leu Asp Leu Gly Phe Glu Glu Trp Asp Val 
65                  70                  75                  80  


Ala Gly Leu Pro Trp Trp Phe Leu Gly Asn Leu Arg Ser Asn Tyr Thr 
                85                  90                  95      


Pro Arg Ser Asn Gly Ser Thr Asp Leu Gln Thr Asn Gln Asp Val Gly 
            100                 105                 110         


Thr Ala Ile Val Ser Asp Thr Thr Asp Asp Leu Trp Phe Leu Asn Glu 
        115                 120                 125             


Ser Val Ser Glu Gln Leu Gly Val Gly Ile Lys Val Glu Ala Ala Asp 
    130                 135                 140                 


Thr Glu Gln Thr Ser Glu Glu Val Gly Lys Val Ser Asp Lys Lys Val 
145                 150                 155                 160 


Ile Glu Val Gly Lys Asn Asp Asp Leu Glu Asp Ser Lys Ser Leu Ser 
                165                 170                 175     


Asp Asp Thr Asp Val Glu Val Thr Ser Glu Asp Glu Trp Gln Cys Thr 
            180                 185                 190         


Glu Cys Lys Lys Phe Asn Ser Pro Ser Lys Arg Tyr Cys Phe Arg Cys 
        195                 200                 205             


Trp Ala Leu Arg Lys Asp Trp Tyr Ser Asp Cys Ser Lys Leu Thr His 
    210                 215                 220                 


Ser Leu Ser Thr Ser Asp Ile Thr Ala Ile Pro Glu Lys Glu Asn Glu 
225                 230                 235                 240 


Gly Asn Asp Val Pro Asp Cys Arg Arg Thr Ile Ser Ala Pro Val Val 
                245                 250                 255     


Arg Pro Lys Asp Ala Tyr Ile Lys Lys Glu Asn Ser Lys Leu Phe Asp 
            260                 265                 270         


Pro Cys Asn Ser Val Glu Phe Leu Asp Leu Ala His Ser Ser Glu Ser 
        275                 280                 285             


Gln Glu Thr Ile Ser Ser Met Gly Glu Gln Leu Asp Asn Leu Ser Glu 
    290                 295                 300                 


Gln Arg Thr Asp Thr Glu Asn Met Glu Asp Cys Gln Asn Leu Leu Lys 
305                 310                 315                 320 


Pro Cys Ser Leu Cys Glu Lys Arg Pro Arg Asp Gly Asn Ile Ile His 
                325                 330                 335     


Gly Arg Thr Gly His Leu Val Thr Cys Phe His Cys Ala Arg Arg Leu 
            340                 345                 350         


Lys Lys Ala Gly Ala Ser Cys Pro Ile Cys Lys Lys Glu Ile Gln Leu 
        355                 360                 365             


Val Ile Lys Val Phe Ile Ala 
    370                 375 

<210>  1322
<211>  5617
<212>  DNA
<213>  Homo sapiens

<400>  1322
ggaaagaata tgtcagaact aatggaatgt tttgtagctt cttagagtgt cacctgtaga     60

agggaattta gggaatagat tctatttact tgagcaacta caagtcctta ccttttaaac    120

tcttcagtac tgtttcttag gtgttatacc tgatttagtg ttaaaagaga aaagtccatg    180

cctgacacca ttatatccat ccattagttt atccacagta ggtgtcaagt agatatatgt    240

tgaatgaata catgtccact gaataaaggc aagatgttct ttggcgatgt agtgtgacga    300

cattgagttt tgggttcatt tgtgttgttt caacatctct gataaacctc tgaatacaga    360

aactcatgtt tgtttttttt ctgttaggat gtgggtactg ccattgtttc agatactaca    420

gatgacttgt ggtttttgaa tgagtcagta tcagagcagt taggtgttgg aataaaagtt    480

gaagctgctg atactgaaca aacaagtgaa gaagtaggga aagtaagtga caaaaaggta    540

tgttgtggaa aaattccatg ttgattctgt ttgtgtgctc atagtatcat ctgttgagat    600

ttctttgtat ctgtttttac aacagattgc tcacataatc ccctttttaa ctttaattaa    660

tttttcaatc caattttaag attcacatta agtaatgtta accagggctg ccttaaaagc    720

ccctacttag tcaaaagcag taagctactc ttttttcccc tgattatagc aacaagctac    780

cttttctctc cctttgctaa caaggtaagg tgctaatcaa gcttgtccaa cccacagcct    840

gtggaccaca tgcggcccag aacaactttg aatcaacaca aattcataaa cttttaaaaa    900

acattatgag ttttcttgcg attttttttc tccttttagc tcatcagtta tcattagtgt    960

tagtgtattt tatgtgtggc ccaagacaat tcttccagtg tgacccaggg aagccaaaag   1020

gttggacacc cctgttgtaa atgaacagca gtctgtagga gaaaacttat ttcttggaaa   1080

tcttgatagc ttccataacc atgttgtacc taaatggaaa gataagatta tttctttgta   1140

gctattttag tgttaaaata gtagaaaaga ggggagattg aactctgagt acatacatat   1200

ggtatgtact catgaagtac tcatgtgtat ggtatgtact catgtacaga tgaagagtca   1260

tacaggcaac ttgctcaaga ctcagaagaa attggggagg agatccagtg gccagcatgt   1320

agaagagtgt tggtaaacat ccatcggata aatacagcaa agaaaaaatt gggtcatcct   1380

ttttagttat ttaagggatt ttcataagaa ttttgagttc ctgaaggata ccctagtata   1440

ttcgttgtag tcaaatggta cctgggttct cttagactag ttatatgggt agcattagaa   1500

ggaatgcagg tggcttgaat taagacaaaa gtgacatttg gaaactttta tttatttatt   1560

tttgagatgg gatctcactg ttttgcccaa cctggtctta aacttcttag ctcaagtggt   1620

ccttccactt cagcctccca agtagctggg gtcacaggca tgtgcagcca tacctggcct   1680

aggaaacgtc tatagagaga gatgggactt aaaatacttg gccatttgtg agaaggttgc   1740

tgtacagagg ttcataattg tttcataatt ggttttattc tttttattgg accacaaaac   1800

tagggcttta aatttttaaa ttctaaattt taaaatttag aacactcctt acttttgaaa   1860

cggacttttt ttgtttgttt ctgtttctgt gggcatgttt ttataggaca gccagagtat   1920

cacataacta gtttcacttt tgaaagtgaa aagtaaattt ttaagatact ttgtttcatt   1980

cttcctgtct gcttagataa aaaattgcac gtttaacaat ttggagcttt tctactctga   2040

aattatttat ttatttattt ttaaattgtt ttagagacaa gctcttattc tgtcacccag   2100

gctggagtgc agtggtgaga tcatagctta ctgcaagccg gaactcttgg gctcaagcga   2160

ttctcttgtc tcagccccca agtaactggg actacaggcg tgcaccacca cacctggcta   2220

atttttttta ttttttgcag agacagggtc ttgctctgtt gcctaggcca gtttcaaact   2280

cctgggctca aggtatcctc ctgccttggc ctcccaaagt gctgaaatta taggcacctg   2340

gctgtaaaat agccaccatg cccagctatt ttctttaaag tcataaatat gggcatcttc   2400

tctcttctga atgcaaaatt tatttggtaa ctcttctggg tgcttttctg tcgtttgtgc   2460

tactactgaa atgccaacta gaagtacaga atcatgtgtt tggtcttgca tttaagctgt   2520

ctccttaagt gctagagatg ggagaagaat gtgagtttta aattgaagca gttgtctttt   2580

ttgctttcag ttaattagcc tcatctaaaa caagtaaaca ttactaatga gatgtttttg   2640

ccttcacagg tgattgaagt gggaaaaaat gatgacctgg aggactctaa gtccttaagt   2700

gatgataccg atgtagaggt tacctctgag gatgagtggc agtgtactga atgcaagaaa   2760

tttaactctc caagcaagag gtactgtttt cgttgttggg ccttgaggaa ggattggtat   2820

tcagattgtt caaagttaac ccattctctc tccacgtctg atatcactgc catacctgaa   2880

aaggaaaatg aaggaaatga tgtccctgat tgtcgaagaa ccatttcggc tcctgtcgtt   2940

agacctaaag atgcgtatat aaagaaagaa aactccaaac tttttgatcc ctgcaactca   3000

gtggaattct tggatttggc tcacagttct gaaagccaag agaccatctc aagcatggga   3060

gaacagttag ataacctttc tgaacagaga acagatacag aaaacatgga ggattgccag   3120

aatctcttga agccatgtag cttatgtgag aaaagaccac gagacgggaa cattattcat   3180

ggaaggacgg gccatcttgt cacttgtttt cactgtgcca gaagactaaa gaaggctggg   3240

gcttcatgcc ctatttgcaa gaaagagatt cagctggtta ttaaggtttt tatagcataa   3300

tggtagtacg aacataaaaa tgcatttatt ccgttcactt accacattat ttgaaaatca   3360

atcctttatt taattttatt tccaacctgt cagagaatgt tcttaggcat caaaatccaa   3420

ggtagctgta agaaaaatac tggagctaac aatgaagaac agaagtaatc tgattagtca   3480

aattattaag tgccatggat tactttatgc agcagtcagg tacatagtta ggtgaaccca   3540

aaagaaaaac tcttgaaaac aagagatttc ttccatgcac atttacaata ttgaggtata   3600

attaacatga taaagtgttt ccttctaacg agttgtagaa atctgagtaa ccacccaaaa   3660

aagcaataga atgtttctgt caccccaaaa cactcccttc tgcccctctt cagacagtcc   3720

ttcagctatt tcatggctct caccctagtt tttttttttt ttgcactttt ttttttccgg   3780

gggtataggg gaggtgtggg gcgacagggt ctgtcttgtt ctgtctccca ggctgaagtg   3840

cagtgcagtg gtatgatcat ggctcactgc agccttggtt tcctgggcat aagtggtctt   3900

cccacttcag cctcctgagt agctgagact atagactagc ataaccacac tggctaattt   3960

tttgtggaga tgaagtctca ctatgttgcc caggctggtc tcgaactcct gggctcaaac   4020

aatcctcccg cctcagcctt ccaaattgct gggattatag tcatgaggca cctagtctgg   4080

cccttttgca agactttaat ctgaaatcta aatttttaaa atttaagtac ttacaaagga   4140

tatactatcc aacatattgc atattatata tgtgctttaa agtttttttt tttttttgag   4200

agacggtctc actttgtcat ccaagctgga gtgcagtggt gcaaacacgg cccacctcct   4260

gggctcaagt gatcctccag cctcagcttc cctcacaggc attcactatc actcccagct   4320

aattaaaata atttgtagac ggtgtctcgt tatgttgccc aggctggtct cgaactcctg   4380

ggtttaagtg attcccccgc ctcagcctcc caaagtgttg ggcttacagc cttgagccac   4440

tatgcttggc tcaaagatat ttttatgaaa gccctgggac tatagattta gctgattaaa   4500

tttatagaaa aagtcctgtc atataaactg gcaaagtctg ttcttaattt aattagccaa   4560

atcagactta acttccgtca gaacatgtct tggttttaat tcagataaac acacaaacat   4620

acttctctgg cacagccttc agaagcatca gtttttgttt tgttttgttt tgttttttga   4680

gacagggtct tgctctgtcg cccaggctgg agtgcactgg cacaatcaca gttcactgca   4740

gcctcgacct cccagatcca agcaatcctc ccacctaagc ctcccaagta gctgggtcta   4800

taggcgcgtg ccaccaccat gcccagctga attttgtatt ttttgtacag acagcatttt   4860

gccatgttgc ccaggctggt cccaaacttc tagcctcaag caaccctcct gcctcagcct   4920

ctcaaagtgc taggattgca gtcctgagct actgccccct accctctttg cgtcttagga   4980

gtcatttaga ttttttttga tccttttgtt tagtgcctct ggagctgctt acaccaaggc   5040

aatacgcctt gatatactgg atggttgaga ggcagcctct tttttttttt tttttttttt   5100

ttttttttgg aggataggga gtatggctgt tgtgaaaagg gaggtaaaga gaaatggtag   5160

atctgaagag gcctcatcag agcacatatt ttaggacaac acatatggaa attggacatc   5220

tttaagttgg tttccataga gctatgcatg tatccttacc cccatgggaa aatgttggtg   5280

tgttctcaag ggtatgcatg tgtcattttg aagaccaagg ccctagaatt gtcaaactta   5340

aggatcataa aaatcatgag ggttgcttgt taaaaatgtc caaacgtgca gagactgatc   5400

tttgagatct ggaccaggaa tttgcatttg aacaagtgtt cctggaatct ctatgcaagt   5460

tttatacaga acatactttt ggaatccttg ccctagacag gggtgtccaa tcttttggct   5520

tccctggtcc acaatggaag aagaattgtc ttggaccaca cataaaatac actaacacta   5580

acaatagctg atgagctaaa aaaaaaaaaa aaaaaaa                            5617


<210>  1323
<211>  222
<212>  PRT
<213>  Homo sapiens

<400>  1323


Met Phe Leu Pro Ser Gln Val Ile Glu Val Gly Lys Asn Asp Asp Leu 
1               5                   10                  15      


Glu Asp Ser Lys Ser Leu Ser Asp Asp Thr Asp Val Glu Val Thr Ser 
            20                  25                  30          


Glu Asp Glu Trp Gln Cys Thr Glu Cys Lys Lys Phe Asn Ser Pro Ser 
        35                  40                  45              


Lys Arg Tyr Cys Phe Arg Cys Trp Ala Leu Arg Lys Asp Trp Tyr Ser 
    50                  55                  60                  


Asp Cys Ser Lys Leu Thr His Ser Leu Ser Thr Ser Asp Ile Thr Ala 
65                  70                  75                  80  


Ile Pro Glu Lys Glu Asn Glu Gly Asn Asp Val Pro Asp Cys Arg Arg 
                85                  90                  95      


Thr Ile Ser Ala Pro Val Val Arg Pro Lys Asp Ala Tyr Ile Lys Lys 
            100                 105                 110         


Glu Asn Ser Lys Leu Phe Asp Pro Cys Asn Ser Val Glu Phe Leu Asp 
        115                 120                 125             


Leu Ala His Ser Ser Glu Ser Gln Glu Thr Ile Ser Ser Met Gly Glu 
    130                 135                 140                 


Gln Leu Asp Asn Leu Ser Glu Gln Arg Thr Asp Thr Glu Asn Met Glu 
145                 150                 155                 160 


Asp Cys Gln Asn Leu Leu Lys Pro Cys Ser Leu Cys Glu Lys Arg Pro 
                165                 170                 175     


Arg Asp Gly Asn Ile Ile His Gly Arg Thr Gly His Leu Val Thr Cys 
            180                 185                 190         


Phe His Cys Ala Arg Arg Leu Lys Lys Ala Gly Ala Ser Cys Pro Ile 
        195                 200                 205             


Cys Lys Lys Glu Ile Gln Leu Val Ile Lys Val Phe Ile Ala 
    210                 215                 220         

<210>  1324
<211>  3572
<212>  DNA
<213>  Homo sapiens

<400>  1324
cgccttgata tactggatgg ttgagaggca gcctcttttt tttttttttt tttttttttt     60

ttttggagga tagggagtat ggctgttgtg aaaagggagg taaagagaaa tggtagatct    120

gaagaggcct catcagagca catattttag gacaacacat atggaaattg gacatcttta    180

agttggtttc catagagcta tgcatgtatc cttaccccca tgggaaaatg ttggtgtgtt    240

ctcaagggta tgcatgtgtc attttgaaga ccaaggccct agaattgtca aacttaagga    300

tcataaaaat catgagggtt gcttgttaaa aatgtccaaa cgtgcagaga ctgatctttg    360

agatctggac caggaatttg catttgaaca agtgttcctg gaatctctat gcaagtttta    420

tacagaacat acttttggaa tccttgccct agacaggggt gtccaatctt ttggcttccc    480

tggtccacaa tggaagaaga attgtcttgg accacacata aaatacacta acactaacaa    540

tagctgatga gctaaaaaaa aaaaaaaaaa aaatcgtgga ccgggcgtag tggctcacgc    600

ctgtaatccc aacactttgg gagatcacct aggtcgggag tttgagacca gcctgaccga    660

catggagaaa ccccattttt actaaaaata caaaaaatta gctgggcatg gtggtgcatg    720

cctgtagtcc tcagcctccc agatagctgg gactacaggc acataccacc atgcctggct    780

aatttttgta tttttagtag agatgggggt ttcactgtgt tggccaggct ggtctcgaac    840

tcctgacctc atgatccaca cacctcggcc tcccaaagtc ctgcgattac aggcgtgagc    900

taccgcaccc agccaagttg taatttttaa taaaacttaa gaagtaaaca ttttacttat    960

gtttataggt atttgatcct aaatttgaca catcattgcc catgaaagaa tcctcttagg   1020

ctgctcagct tcactcttcc tgcttgccca ccggggtttt tcactgcttc tgttagcact   1080

aagtacttag acgatcctaa gatatgtgct tgagccgaat ttcatcttta cttgtaggaa   1140

actttaaact atttcttttc ttttcttttt tttttttttt tacttgagat ggagttttgc   1200

tcttgtcgcc caggctggag tgcagtggag tgatctcggc tcactgcaac ctctgcctcc   1260

cgggttcaaa tgattctcct gcctcagcct cccaagtagc tgggattaca ggtgtgcacc   1320

accatgtctg gctaattttg tatttttagt agagatggtt tcaccatgtt ggtcaggctg   1380

gtctcgaact cctgacctca ggtcatccac ccacctcagc ctcgcaaagt gctgagatta   1440

caggcatgag ccacagcgcc cagcttaaac tattttcttg gtctgttttt gattttcttt   1500

tttccttgcc actgcggtac agattttttt tactcactgc cactaaacta aagcaaggca   1560

tagtttatat gtgaagtgtt cagagtttac tgctataagg aaacttccaa atactgacat   1620

ttacctttta gctgtagtta ttgggaccat gtgctctggt tttctggaga ctgccaaatt   1680

gctcccattt ttctgcatcc cacctggttt ctttctgcat gtcccctttc actttcaaac   1740

ctcttcattt ggatgttaaa ttatatggtc acctagttat aggtaagcct tgttcgagtt   1800

gatatcttga ttgtgaggaa ggatctgtgt cattggagct tgtttctgct gcaacgtgct   1860

gtagactatg aataatgaaa tcacaccaca ttaccatcag atttcttgtt ttagttgtca   1920

aattaatatt tatgattgtt atcttgggcg aaaagttcag agcagagatg acaaatcatt   1980

agaacaacga tgaatttcag tattacggct aaaaagttct tctgtctgaa tattaactca   2040

ctctccttcc agtgtacttc acagtaattg gtatgctttt ttatttaatg cttaaatcaa   2100

actttataaa aatcttagac cagatcttta atatggtatg ccatttcccc agtctaccaa   2160

tggaatagta tgggtttcta atcctaggct tgtacaatgg attggagttg agccatgcca   2220

gcctccacac tgccactaac ttctgtaatg taagattgag tcactgccaa gcatttgaaa   2280

tatgcagttg tgttttaatt ataatttatg tatagttaga tgtatgtagt gcattgtgtg   2340

gtattatttg gtttgtaaga atttattttt aagggtcaag gtcatttgta acattttgtg   2400

tgtgtcaatt caatgcaatg ttggctgcct tttgaagtct ttgatatatt ggtgaatatt   2460

cttctgatct ataatacaaa gctatgtaat gttacctctt gactcgcttt tgaaaggaag   2520

acaattgtta actagatatt tgagtttttt cccctcagaa ttatgtgaat ttctgatata   2580

tggctttaga tactgtgaat ctgttttcca tttagtcagt tatctgctta aattgttcag   2640

aactatatcc taacgagcaa ttagttctga tggttctccc agtcatgagt gtgcatgtgt   2700

gcaagcatgt tttgatcctg atgctacctt tgctaaaaat ggccatagat taggaactag   2760

ctatgttttt agaatcaaag atgaaccggt aagctgtctc atgtaccaaa cgtgaaattt   2820

acagtgttta caaatgtctg gaattttgca ctgccatagg gaatgttaag gttacttggc   2880

tggaatttat cagacttgtg agtaaacaag ttgaagttta gcagatgagg gggaatattg   2940

aggcccctaa ggctaaacaa aataatcagt atctgagata gtggctaatg tggctcccca   3000

ggcctaattt gggaacagtt tttcctgatt gctttgagaa gtactttctt ttgacagaaa   3060

ttttcattct gcttgccatt gctatattct ccctttatag gagccattgg atttctttcc   3120

ttttgtggga aatgtcccat tagcattttc agatcttttg atgtgcacta atgccattat   3180

tggtaatgcc gttattggtg aatacagcat agttaaataa actgttacag taaatctaca   3240

cttggatttg ctgcacctct accaatagcc ttttgaatga ctgaaagtgt taacagagaa   3300

agaggcatgt ctgcagaaag agatagctaa tattttttgg tactttatct gaaatccaag   3360

atgctgcttc ccctgcaggt tgttttcctt cttacgatcc tcattgaatc ccctctggga   3420

gcacaggaca gttagtagaa ctctccattt cttttttttt ttttttagac ggagtctctc   3480

tctgtcgccc cggctggagt gcagtggcgc gatctcggct cactgcaacc tccgcctccc   3540

gggttcaccc cattctcctg cctcagcctc cc                                 3572


<210>  1325
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  1325


Met Pro Val Val Leu Ser Leu Pro Asp Ser Trp Asp Tyr Arg His Ile 
1               5                   10                  15      


Pro Pro Cys Leu Ala Asn Phe Cys Ile Phe Ser Arg Asp Gly Gly Phe 
            20                  25                  30          


Thr Val Leu Ala Arg Leu Val Ser Asn Ser 
        35                  40          

<210>  1326
<211>  3259
<212>  DNA
<213>  Homo sapiens

<400>  1326
cgccttgata tactggatgg ttgagaggca gcctcttttt tttttttttt tttttttttt     60

ttttggagga tagggagtat ggctgttgtg aaaagggagg taaagagaaa tggtagatct    120

gaagaggcct catcagagca catattttag gacaacacat atggaaattg gacatcttta    180

agttggtttc catagagcta tgcatgtatc cttaccccca tgggaaaatg ttggtgtgtt    240

ctcaagggta tgcatgtgtc attttgaaga ccaaggccct agaattgtca aacttaagga    300

tcataaaaat catgagggtt gcttgttaaa aatgtccaaa cgtgcagaga ctgatctttg    360

agatctggac caggaatttg catttgaaca agtgttcctg gaatctctat gcaagtttta    420

tacagaacat acttttggaa tccttgccct agacaggggt gtccaatctt ttggcttccc    480

tggtccacaa tggaagaaga attgtcttgg accacacata aaatacacta acactaacaa    540

tagctgatga gctaaaaaaa aaaaaaaaaa aaatcgtgga ccgggcctac cgcacccagc    600

caagttgtaa tttttaataa aacttaagaa gtaaacattt tacttatgtt tataggtatt    660

tgatcctaaa tttgacacat cattgcccat gaaagaatcc tcttaggctg ctcagcttca    720

ctcttcctgc ttgcccaccg gggtttttca ctgcttctgt tagcactaag tacttagacg    780

atcctaagat atgtgcttga gccgaatttc atctttactt gtaggaaact ttaaactatt    840

tcttttcttt tctttttttt ttttttttac ttgagatgga gttttgctct tgtcgcccag    900

gctggagtgc agtggagtga tctcggctca ctgcaacctc tgcctcccgg gttcaaatga    960

ttctcctgcc tcagcctccc aagtagctgg gattacaggt gtgcaccacc atgtctggct   1020

aattttgtat ttttagtaga gatggtttca ccatgttggt caggctggtc tcgaactcct   1080

gacctcaggt catccaccca cctcagcctc gcaaagtgct gagattacag gcatgagcca   1140

cagcgcccag cttaaactat tttcttggtc tgtttttgat tttctttttt ccttgccact   1200

gcggtacaga ttttttttac tcactgccac taaactaaag caaggcatag tttatatgtg   1260

aagtgttcag agtttactgc tataaggaaa cttccaaata ctgacattta ccttttagct   1320

gtagttattg ggaccatgtg ctctggtttt ctggagactg ccaaattgct cccatttttc   1380

tgcatcccac ctggtttctt tctgcatgtc ccctttcact ttcaaacctc ttcatttgga   1440

tgttaaatta tatggtcacc tagttatagg taagccttgt tcgagttgat atcttgattg   1500

tgaggaagga tctgtgtcat tggagcttgt ttctgctgca acgtgctgta gactatgaat   1560

aatgaaatca caccacatta ccatcagatt tcttgtttta gttgtcaaat taatatttat   1620

gattgttatc ttgggcgaaa agttcagagc agagatgaca aatcattaga acaacgatga   1680

atttcagtat tacggctaaa aagttcttct gtctgaatat taactcactc tccttccagt   1740

gtacttcaca gtaattggta tgctttttta tttaatgctt aaatcaaact ttataaaaat   1800

cttagaccag atctttaata tggtatgcca tttccccagt ctaccaatgg aatagtatgg   1860

gtttctaatc ctaggcttgt acaatggatt ggagttgagc catgccagcc tccacactgc   1920

cactaacttc tgtaatgtaa gattgagtca ctgccaagca tttgaaatat gcagttgtgt   1980

tttaattata atttatgtat agttagatgt atgtagtgca ttgtgtggta ttatttggtt   2040

tgtaagaatt tatttttaag ggtcaaggtc atttgtaaca ttttgtgtgt gtcaattcaa   2100

tgcaatgttg gctgcctttt gaagtctttg atatattggt gaatattctt ctgatctata   2160

atacaaagct atgtaatgtt acctcttgac tcgcttttga aaggaagaca attgttaact   2220

agatatttga gttttttccc ctcagaatta tgtgaatttc tgatatatgg ctttagatac   2280

tgtgaatctg ttttccattt agtcagttat ctgcttaaat tgttcagaac tatatcctaa   2340

cgagcaatta gttctgatgg ttctcccagt catgagtgtg catgtgtgca agcatgtttt   2400

gatcctgatg ctacctttgc taaaaatggc catagattag gaactagcta tgtttttaga   2460

atcaaagatg aaccggtaag ctgtctcatg taccaaacgt gaaatttaca gtgtttacaa   2520

atgtctggaa ttttgcactg ccatagggaa tgttaaggtt acttggctgg aatttatcag   2580

acttgtgagt aaacaagttg aagtttagca gatgaggggg aatattgagg cccctaaggc   2640

taaacaaaat aatcagtatc tgagatagtg gctaatgtgg ctccccaggc ctaatttggg   2700

aacagttttt cctgattgct ttgagaagta ctttcttttg acagaaattt tcattctgct   2760

tgccattgct atattctccc tttataggag ccattggatt tctttccttt tgtgggaaat   2820

gtcccattag cattttcaga tcttttgatg tgcactaatg ccattattgg taatgccgtt   2880

attggtgaat acagcatagt taaataaact gttacagtaa atctacactt ggatttgctg   2940

cacctctacc aatagccttt tgaatgactg aaagtgttaa cagagaaaga ggcatgtctg   3000

cagaaagaga tagctaatat tttttggtac tttatctgaa atccaagatg ctgcttcccc   3060

tgcaggttgt tttccttctt acgatcctca ttgaatcccc tctgggagca caggacagtt   3120

agtagaactc tccatttctt tttttttttt tttagacgga gtctctctct gtcgccccgg   3180

ctggagtgca gtggcgcgat ctcggctcac tgcaacctcc gcctcccggg ttcaccccat   3240

tctcctgcct cagcctccc                                                3259


<210>  1327
<211>  54
<212>  PRT
<213>  Homo sapiens

<400>  1327


Met Leu Pro Leu Asp Ser Leu Leu Lys Gly Arg Gln Leu Leu Thr Arg 
1               5                   10                  15      


Tyr Leu Ser Phe Phe Pro Ser Glu Leu Cys Glu Phe Leu Ile Tyr Gly 
            20                  25                  30          


Phe Arg Tyr Cys Glu Ser Val Phe His Leu Val Ser Tyr Leu Leu Lys 
        35                  40                  45              


Leu Phe Arg Thr Ile Ser 
    50                  

<210>  1328
<211>  2352
<212>  DNA
<213>  Homo sapiens

<400>  1328
ggggtttcac cgtcttagcc aggatggtct tgatctcctg acctcgtgat ctgcccactg     60

cgctcccacc tgggtgacag agactctgtc tcaaaaaaaa ggacatttat cattataaca    120

tcttattaga gcccctaatt tcttatctga aggcactgtt ttttttttta aacagttaag    180

tactgatgtc aacagacaaa tatttctgat cagatagtcc cctgtcaaca gtagcaaatg    240

tggtttcata aagtgggaag aaaacagcat tttaaagtaa ctttttggga gactgatttg    300

agtaataata aaactctggt ctcccttaag aaaaaaaaac ccttccacct ttactgtgtc    360

atttatatcc ccttagttcc aaagttaatt atcttatttc tggatattgc ttttatacca    420

aagaccctta tcagcccttg taactacagt atctttagat aagattcctc tttccagtca    480

gtcctgggaa atgtttctgt tgcagagtta ggcggtagat gggaagctgt gatggcagag    540

ctactatcta ataaagtaac aactcgtagt tgaggcttcc tttctgtgtg tgatggggga    600

tagggagtta gctcccctgt tgtctcagca ctaagaaatt gaggtcaggc caggcgcggt    660

ggttcactcc tgttattcca gcactggggt ggccaaagtg ggcagattgc ttgcgctctg    720

gagctcgaga ccagcctggg caacatggtg aaaccctgtc tctaccaaaa atacaaaaaa    780

aaagctgggc atggtgggtg catgcttgtc ccagctactg aggaggctga ggtgggagga    840

tcgcttgagc ctgggaggtg gaggttgcag tgagctgaga tggcaccact gcaatccaag    900

gtgggtgaca gagacgctgt ctcaaagaaa ttgaggtcag gcttccttct tacagaatta    960

tttttttctc tgtagtttgc ctcatttttt cactttcttt tcaatgagaa tcgaagtgtt   1020

tcttttgggt ttttttttcc cccttttaaa atcaacagga aatgtttcaa aggagggatg   1080

aaatgcttct tggcttcctc agcacttggc aaggtagacc tcatagcaac cttgaatatg   1140

actttcttta gtctctagct atgcactatt aagtgcctct tgggtagagg tagagttaag   1200

tattgagtgc cagtcttgac gtccgtatgc ctcagttttt ctcatatata aaaagcagta   1260

tacataccta cccttttcta cctcatcatt tgttgtaggg attaaatccg ggagagcaat   1320

tctgaagcct ataaatttcc ttgaagagat ctaagaacct attatgctct tggtgtacca   1380

agctctgggg tatatattca gaatacctca tgttctggaa gctgagcact agctcccctt   1440

tattgcctgc ctggcagagc ctgtttgatt actgcaggcc cttttaccca tgcttctagt   1500

ttaggtattc tttctttgat atgaggctct tgaccagaaa agagttcttt ctctaggtgt   1560

tctgagagaa gtttgtaaat ttggatagta cattctatcc tgataaaacc accttgctgt   1620

ggtcttgatg tacaaaaaaa aatttttttt ttgagacaga gtcttactct gtcacccagg   1680

ctggaatgca gtggcgcaat cttggttcac tgcaaccccc gcctcctggg ttcaagcgat   1740

cctcctgcct caacctctca agtagctggg actacaggcg tgcaccacca cacctggcta   1800

attttgtatt tttagtagag acagggtttc accatgttgg ccaggctggt cttgaactcc   1860

tgacctcagg cgatctgccc gccttggcct cccaaagtac tgggattaca ggcgtgagca   1920

actgctcctg gcccaaaaca tctctttcta catacacttg agtaggtggc ataaaatgca   1980

ctgtcaatat atagaaaaca tgaaattttc caaatatttc cgatcagaga atcacaagag   2040

cagcaaatgt ggtttcatca agtgggaaga aagcagcaat ttaaaataac tttttgggag   2100

actgaattga gtaataataa aacttcagtc tttcgctaat aataataata ataataataa   2160

taacaacaac ttattgaatg tggccagctc actagatgag gaaagaggaa ggcattttct   2220

gcattcttgc ctagttttcc ttataagcac cactaagtta atagctctgt ctttttggtg   2280

tttgcactat gtaatgcttt taatactttt taattgtgct tttttatgta ttaaatgttt   2340

ttccttttgc ca                                                       2352


<210>  1329
<211>  91
<212>  PRT
<213>  Homo sapiens

<400>  1329


Met Gln Trp Arg Asn Leu Gly Ser Leu Gln Pro Pro Pro Pro Gly Phe 
1               5                   10                  15      


Lys Arg Ser Ser Cys Leu Asn Leu Ser Ser Ser Trp Asp Tyr Arg Arg 
            20                  25                  30          


Ala Pro Pro His Leu Ala Asn Phe Val Phe Leu Val Glu Thr Gly Phe 
        35                  40                  45              


His His Val Gly Gln Ala Gly Leu Glu Leu Leu Thr Ser Gly Asp Leu 
    50                  55                  60                  


Pro Ala Leu Ala Ser Gln Ser Thr Gly Ile Thr Gly Val Ser Asn Cys 
65                  70                  75                  80  


Ser Trp Pro Lys Thr Ser Leu Ser Thr Tyr Thr 
                85                  90      

<210>  1330
<211>  545
<212>  DNA
<213>  Homo sapiens

<400>  1330
ggaactctcc atttcttaag gtaaagaggg tcaaggatac ctaaaaaggg tcaaataatg     60

ctagaagagc aattcctctt tcagagcagt tgctgtaatt tggcaaatgc tttatcgaag    120

attgatcaaa acatctcttt ctacatacac ttgagtaggt ggcataaaat gcactgtcaa    180

tatatagaaa acatgaaatt ttccaaatat ttccgatcag agaatcacaa gagcagcaaa    240

tgtggtttca tcaagtggga agaaagcagc aatttaaaat aactttttgg gagactgaat    300

tgagtaataa taaaacttca gtctttcgct aataataata ataataataa taataacaac    360

aacttattga atgtggccag ctcactagat gaggaaagag gaaggcattt tctgcattct    420

tgcctagttt tccttataag caccactaag ttaatagctc tgtctttttg gtgtttgcac    480

tatgtaatgc ttttaatact ttttaattgt gcttttttat gtattaaatg tttttccttt    540

tgcca                                                                545


<210>  1331
<211>  74
<212>  PRT
<213>  Homo sapiens

<400>  1331


Met Leu Glu Glu Gln Phe Leu Phe Gln Ser Ser Cys Cys Asn Leu Ala 
1               5                   10                  15      


Asn Ala Leu Ser Lys Ile Asp Gln Asn Ile Ser Phe Tyr Ile His Leu 
            20                  25                  30          


Ser Arg Trp His Lys Met His Cys Gln Tyr Ile Glu Asn Met Lys Phe 
        35                  40                  45              


Ser Lys Tyr Phe Arg Ser Glu Asn His Lys Ser Ser Lys Cys Gly Phe 
    50                  55                  60                  


Ile Lys Trp Glu Glu Ser Ser Asn Leu Lys 
65                  70                  

<210>  1332
<211>  1115
<212>  DNA
<213>  Homo sapiens

<400>  1332
agactgcacc actgcgctcc cacctgggtg acagagactc tgtctcaaaa aaaaggacat     60

ttatcattat aacatcttat tagagcccct aatttcttat ctgaaggcac tgtttttttt    120

tttaaacagt taagtactga tgtcaacaga caaatatttc tgatcagata gtcccctgtc    180

aacagtagca aatgtggttt cataaagtgg gaagaaaaca gcattttaaa gtaacttttt    240

gggagactga tttgagtaat aataaaactc tggtctccct taagaaaaaa aaacccttcc    300

acctttactg tgtcatttat atccccttag ttccaaagtt aattatctta tttctggata    360

ttgcttttat accaaagacc cttatcagcc cttgtaacta cagtatcttt agataagatt    420

cctctttcca gtcagtcctg ggaaatgttt ctgttgcaga gttaggcggt agatgggaag    480

ctgtgatggc agagctacta tctaataaag taacaactcg tagttgaggc ttcctttctg    540

tgtgtgatgg gggataggga gttagctccc ctgttgtctc agcactaaga aattgaggtc    600

aggccaggct ggtcttgaac tcctgacctc aggcgatctg cccgccttgg cctcccaaag    660

tactgggatt acaggcgtga gcaactgctc ctggcccaaa acatctcttt ctacatacac    720

ttgagtaggt ggcataaaat gcactgtcaa tatatagaaa acatgaaatt ttccaaatat    780

ttccgatcag agaatcacaa gagcagcaaa tgtggtttca tcaagtggga agaaagcagc    840

aatttaaaat aactttttgg gagactgaat tgagtaataa taaaacttca gtctttcgct    900

aataataata ataataataa taataacaac aacttattga atgtggccag ctcactagat    960

gaggaaagag gaaggcattt tctgcattct tgcctagttt tccttataag caccactaag   1020

ttaatagctc tgtctttttg gtgtttgcac tatgtaatgc ttttaatact ttttaattgt   1080

gcttttttat gtattaaatg tttttccttt tgcca                              1115


<210>  1333
<211>  74
<212>  PRT
<213>  Homo sapiens

<400>  1333


Met Trp Phe His Lys Val Gly Arg Lys Gln His Phe Lys Val Thr Phe 
1               5                   10                  15      


Trp Glu Thr Asp Leu Ser Asn Asn Lys Thr Leu Val Ser Leu Lys Lys 
            20                  25                  30          


Lys Lys Pro Phe His Leu Tyr Cys Val Ile Tyr Ile Pro Leu Val Pro 
        35                  40                  45              


Lys Leu Ile Ile Leu Phe Leu Asp Ile Ala Phe Ile Pro Lys Thr Leu 
    50                  55                  60                  


Ile Ser Pro Cys Asn Tyr Ser Ile Phe Arg 
65                  70                  

<210>  1334
<211>  1177
<212>  DNA
<213>  Homo sapiens

<400>  1334
agactgcacc actgcgctcc cacctgggtg acagagactc tgtctcaaaa aaaaggacat     60

ttatcattat aacatcttat tagagcccct aatttcttat ctgaaggcac tgtttttttt    120

tttaaacagt taagtactga tgtcaacaga caaatatttc tgatcagata gtcccctgtc    180

aacagtagca aatgtggttt cataaagtgg gaagaaaaca gcattttaaa gtaacttttt    240

gggagactga tttgagtaat aataaaactc tggtctccct taagaaaaaa aaacccttcc    300

acctttactg tgtcatttat atccccttag ttccaaagtt aattatctta tttctggata    360

ttgcttttat accaaagacc cttatcagcc cttgtaacta cagtatcttt agataagatt    420

cctctttcca gtcagtcctg ggaaatgttt ctgttgcaga gttaggcggt agatgggaag    480

ctgtgatggc agagctacta tctaataaag taacaactcg tagttgaggc ttcctttctg    540

tgtgtgatgg gggataggga gttagctccc ctgttgtctc agcactaaga aattgaggtc    600

aggccaggcg cggtggttca ctcctgttat tccagcactg gggtggccaa agtgggcaga    660

ttgcttgcgc ttggtcttga actcctgacc tcaggcgatc tgcccgcctt ggcctcccaa    720

agtactggga ttacaggcgt gagcaactgc tcctggccca aaacatctct ttctacatac    780

acttgagtag gtggcataaa atgcactgtc aatatataga aaacatgaaa ttttccaaat    840

atttccgatc agagaatcac aagagcagca aatgtggttt catcaagtgg gaagaaagca    900

gcaatttaaa ataacttttt gggagactga attgagtaat aataaaactt cagtctttcg    960

ctaataataa taataataat aataataaca acaacttatt gaatgtggcc agctcactag   1020

atgaggaaag aggaaggcat tttctgcatt cttgcctagt tttccttata agcaccacta   1080

agttaatagc tctgtctttt tggtgtttgc actatgtaat gcttttaata ctttttaatt   1140

gtgctttttt atgtattaaa tgtttttcct tttgcca                            1177


<210>  1335
<211>  74
<212>  PRT
<213>  Homo sapiens

<400>  1335


Met Trp Phe His Lys Val Gly Arg Lys Gln His Phe Lys Val Thr Phe 
1               5                   10                  15      


Trp Glu Thr Asp Leu Ser Asn Asn Lys Thr Leu Val Ser Leu Lys Lys 
            20                  25                  30          


Lys Lys Pro Phe His Leu Tyr Cys Val Ile Tyr Ile Pro Leu Val Pro 
        35                  40                  45              


Lys Leu Ile Ile Leu Phe Leu Asp Ile Ala Phe Ile Pro Lys Thr Leu 
    50                  55                  60                  


Ile Ser Pro Cys Asn Tyr Ser Ile Phe Arg 
65                  70                  

<210>  1336
<211>  1030
<212>  DNA
<213>  Homo sapiens

<400>  1336
ataaaaagca gtatacatac ctaccctttt ctacctcatc atttgttgta gggattaaat     60

ccgggagagc aattctgaag cctataaatt tccttgaaga gatctaagaa cctattatgc    120

tcttggtgta ccaagctctg gggtatatat tcagaatacc tcatgttctg gaagctgagc    180

actagctccc ctttattgcc tgcctggcag agcctgtttg attactgcag gcccttttac    240

ccatgcttct agtttaggta ttctttcttt gatatgaggc tcttgaccag aaaagagttc    300

tttctctagg tgttctgaga gaagtttgta aatttggata gtacattcta tcctgataaa    360

accaccttgc tgtggtcttg atgtacaaaa aaaaattttt tttttgagac agagtcttac    420

tctgtcaccc aggctggaat gcagtggcgc aatcttggtt cactgcaacc cccgcctcct    480

gggttcaagc gatcctcctg cctcaacctc tcaagtagct gggactacag gcgtgcacca    540

ccacacctgg ctaattttgt atttttagta gagacagggt ttcaccatgt tggccaggct    600

ggtcttgaac tcctgacctc aggcgatctg cccgccttgg cctcccaaag tactgggatt    660

acaggcgtga gcaactgctc ctggcccaaa acatctcttt ctacatacac ttgagtaggt    720

ggcataaaat gcactgtcaa tatatagaaa acatgaaatt ttccaaatat ttccgatcag    780

agaatcacaa gagcagcaaa tgtggtttca tcaagtggga agaaagcagc aatttaaaat    840

aactttttct tattgaatgt ggccagctca ctagatgagg aaagaggaag gcattttctg    900

cattcttgcc tagttttcct tataagcacc actaagttaa tagctctgtc tttttggtgt    960

ttgcactatg taatgctttt aatacttttt aattgtgctt ttttatgtat taaatgtttt   1020

tccttttgcc                                                          1030


<210>  1337
<211>  91
<212>  PRT
<213>  Homo sapiens

<400>  1337


Met Gln Trp Arg Asn Leu Gly Ser Leu Gln Pro Pro Pro Pro Gly Phe 
1               5                   10                  15      


Lys Arg Ser Ser Cys Leu Asn Leu Ser Ser Ser Trp Asp Tyr Arg Arg 
            20                  25                  30          


Ala Pro Pro His Leu Ala Asn Phe Val Phe Leu Val Glu Thr Gly Phe 
        35                  40                  45              


His His Val Gly Gln Ala Gly Leu Glu Leu Leu Thr Ser Gly Asp Leu 
    50                  55                  60                  


Pro Ala Leu Ala Ser Gln Ser Thr Gly Ile Thr Gly Val Ser Asn Cys 
65                  70                  75                  80  


Ser Trp Pro Lys Thr Ser Leu Ser Thr Tyr Thr 
                85                  90      

<210>  1338
<211>  572
<212>  DNA
<213>  Homo sapiens

<400>  1338
acttcctgca ccactggcag cgggctggcc aatgggatgc aagtggaaat gaactgtgct     60

attctgagca gaggcttagg gaccattgtg tggttagcct aaaaacaaca gcagaagcag    120

cagcaacaac gatgctgagt gctgactgcg agcctggctt cctcggaggg agtttaccgt    180

gcgctgcctc cttggaccct catcactgcc ctgcgaagca agcactttcc tcaccccctc    240

tgtctggagg agggcactga ggcaccgaga aaactgggca ggggaggccc gagaaggaga    300

gggtggcacc gtcattctca ctttccagct gaggacacgg atggtttcta taacagtgaa    360

tttgcaaata gttggaacct ctgaagtgct tcctctcctg gactggaaac cccttgagga    420

tgtgtacggc acccgcatcc cctccatctg cacccgcagc cacagccaca gccacagcca    480

gcgctatgtc ccgttgccat tcacattcat acctgcaacg tacactcata catgtgtcgg    540

atatttgcga agaagctccc tttcccacct ag                                  572


<210>  1339
<211>  76
<212>  PRT
<213>  Homo sapiens

<400>  1339


Met Val Ser Ile Thr Val Asn Leu Gln Ile Val Gly Thr Ser Glu Val 
1               5                   10                  15      


Leu Pro Leu Leu Asp Trp Lys Pro Leu Glu Asp Val Tyr Gly Thr Arg 
            20                  25                  30          


Ile Pro Ser Ile Cys Thr Arg Ser His Ser His Ser His Ser Gln Arg 
        35                  40                  45              


Tyr Val Pro Leu Pro Phe Thr Phe Ile Pro Ala Thr Tyr Thr His Thr 
    50                  55                  60                  


Cys Val Gly Tyr Leu Arg Arg Ser Ser Leu Ser His 
65                  70                  75      

<210>  1340
<211>  2756
<212>  DNA
<213>  Homo sapiens

<400>  1340
caaaagagtc taacataaga gaaatggtca gataggaggg cagaatggat cactgttaat     60

tatgaggact ttggaggcaa actgcccaga ttcaaatccc tgttccaccc cttgctagca    120

gtgtgacccc aagcaagtca tttaacttct ctgtacttca tctgtcaaat tcactcatca    180

caatacttaa ctcacagggc tgccgttaat tagttaatgt ccacatgtat ctgattagaa    240

gagcacactg tgtaacacag cccattacga ctgctctaat tccagcccac agggccagct    300

ggccggggcc cctttccaca gcagtggtga gtccagatgg gccacacctg ctgctgctcc    360

agggctgcat ccccttgtgc tgtcctccca aggctacatc tgcaagtgga gaggatttgg    420

ctatcactca ctgggggaga gataagtgtg gaagcaggag ggggaattgg ggaaggaggg    480

aggctgcgtg tgggacacct tcggaagccc ttgtcttctt cgtagtcccc agggaaagga    540

acgcctgcct gctctgtaga gggcaggctg agctctgagt gtgggcttcc tattctcaca    600

gcagctagtt tcatacttaa aagtctgaag ccagatatat tctgccacca gattaatttt    660

tttctgaagc tcccatttgg tctgttggag gaattcacat tcctccggct gtcataactt    720

tgctctgtct ttcaagagct cacacccctg gccttgtttt gcaaatagag cattctttct    780

ctcctgcctg tcctttacct tacaaagctt ccccatactg aacaaaaaca ttttcaactg    840

ctctgtagtg gaaggtaggg aggccggggt ggaagtaaag ggtaattaaa taatttctgc    900

tgcagcacga aaagctgaac agcatgaagt attattaata cgatgtgctc ttcctaatga    960

attaacacag gcaatccctc tctcctgtct ggtgttcagt aaatatttgt tgaatgaatg   1020

aataacagct tatgattctg tctttcctgc tctgatgaat tatgaagtcc atgtagccaa   1080

atcagcatca aacccatttt atatgcagtc tgtgttttga gccccaggtc aaagtgaata   1140

aaatatgtgt gaaaatgaag taataatgtc cattggagac cactggcttc ctgtatttgt   1200

aggggatagg gtctacctgg cttggtattg gtgacttgag agtagccttc cagctgcttt   1260

tctctggttc ccaggtaaac cagggtcagg ctgtcccttc taggtggaac tctgttgaga   1320

ccccacaggc agctctggtg aatgaccagc atgtgcaaac tcattgctct ccagctgacc   1380

ccaaaaccat gcaggaagaa gggcaattcc tgcaggactg agtctgcccc cggctgagcc   1440

ttgctttgct cattgcagat atttaagtct ctccatagtg ctgtgactca cctgtctgtc   1500

cttggttgga attccacagg gaaatcacat gcagaacctg gtcactatct gtacacaaag   1560

cacatggaga gattctaggg acaatcattt ctaagtaaat tacctaaggg cagaagagtc   1620

tgcccgggag ctgggggaga atggagcagg gacaggagat gggaataagt gacttgtaca   1680

ttaatcacaa agcaatcagc agatgacaag gggccttgga accaccacgt ctgtctagct   1740

ggacgaggtg aaagaaaagg tcacccttgt ctgggaactc tcatccatct tcaagacaca   1800

cacttacctg gcttgcatgt gcctgagctt cctgtttttc ccgcccagca gagatgctgc   1860

cctggcctgg ttcattgtcc attatttgcc ctctgggcca tcccagcatc cacctggcct   1920

gccccacctg gcccaggcca cagaggaggg catggctttg gctagttgac ctttaggaag   1980

tcatttactg ggtgtaaccc acctcagttc ctgagacctg taaactcctc tttctctgcc   2040

ctgaatcttc cccagttatc agggcccaag caggagagtg ggcgtgaact ctcagcgctc   2100

ttcccctaac tttttccctt gatcctcccc agcttcttcc ctctcctggc aacccacccc   2160

ctgcccactg tcccctgaac acagaggctc ctgatggatg gagctgtctt cttacttccg   2220

ctggccctcc ctgggctgta cactagccct tggatcaaaa cctgttccca agttcagatc   2280

aatttctttc tgacatattt tcacaaaagt gggttttgtc tcccaggtca tttgaatttg   2340

aactggagca atgtccttgc ccaggtgtaa cccttggcag tggattttgg cagtggtgat   2400

gagtttggag tagaaaaaaa gagtcctgat tagaatggct actccatggc tcagatcaca   2460

gatagagcat gagatttgga tttaggcctt ggatttattt tggacaatgc ctgagcaaca   2520

ttacctgggt cccctagccc agcagggttc tccttgtctc agccaaagat gggaagctga   2580

cttggttagg ctgggcatcc agacaccgag gctgaataga aaagagataa gaaaattaca   2640

acttacagac tgaccctggg gatgccagag ggtggtccag atggagtaaa ccccaaaaat   2700

gaccttctct ggtgttagcc tccacatgca ttctgtctat tgtgctgcat ggcttg       2756


<210>  1341
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  1341


Met Tyr Leu Ile Arg Arg Ala His Cys Val Thr Gln Pro Ile Thr Thr 
1               5                   10                  15      


Ala Leu Ile Pro Ala His Arg Ala Ser Trp Pro Gly Pro Leu Ser Thr 
            20                  25                  30          


Ala Val Val Ser Pro Asp Gly Pro His Leu Leu Leu Leu Gln Gly Cys 
        35                  40                  45              


Ile Pro Leu Cys Cys Pro Pro Lys Ala Thr Ser Ala Ser Gly Glu Asp 
    50                  55                  60                  


Leu Ala Ile Thr His Trp Gly Arg Asp Lys Cys Gly Ser Arg Arg Gly 
65                  70                  75                  80  


Asn Trp Gly Arg Arg Glu Ala Ala Cys Gly Thr Pro Ser Glu Ala Leu 
                85                  90                  95      


Val Phe Phe Val Val Pro Arg Glu Arg Asn Ala Cys Leu Leu Cys Arg 
            100                 105                 110         


Gly Gln Ala Glu Leu 
        115         

<210>  1342
<211>  552
<212>  DNA
<213>  Homo sapiens

<400>  1342
cctaaccaag tcagcttccc atctttggct gagacaagga gaaccctgct gggctagggg     60

acccagatag tgaccaggtt ctgcatgtga tttccctgtg gaattccaac caaggacaga    120

cagggagagg ctacaggaca aatggaacca agaggagacc cagaaggcag aggcccgagc    180

agtgtgtccc tgagatgccc agttagccta aaaacaacag cagaagcagc agcaacaacg    240

atgctgagtg ctgactgcga gcctggcttc ctcggaggga gtttaccgtg cgctgcctcc    300

ttggaccctc atcactgccc tgcgaagcaa gcactttcct caccccctct gtctggagga    360

gggcactgag gcaccgagaa aactgggcag gggaggcccg agaaggagag ggtggcaccg    420

tcattctcac tttccagctg aggacacggg taagtggcat gcgtccgctc ctgtgactta    480

caggagtccc gggactcgca ctcgggcctc tggactccta gcctggtgtt ttcccctgga    540

agtttctgaa cc                                                        552


<210>  1343
<211>  75
<212>  PRT
<213>  Homo sapiens

<400>  1343


Met Glu Pro Arg Gly Asp Pro Glu Gly Arg Gly Pro Ser Ser Val Ser 
1               5                   10                  15      


Leu Arg Cys Pro Val Ser Leu Lys Thr Thr Ala Glu Ala Ala Ala Thr 
            20                  25                  30          


Thr Met Leu Ser Ala Asp Cys Glu Pro Gly Phe Leu Gly Gly Ser Leu 
        35                  40                  45              


Pro Cys Ala Ala Ser Leu Asp Pro His His Cys Pro Ala Lys Gln Ala 
    50                  55                  60                  


Leu Ser Ser Pro Pro Leu Ser Gly Gly Gly His 
65                  70                  75  

<210>  1344
<211>  367
<212>  DNA
<213>  Homo sapiens

<400>  1344
ggatgtcaca tgggggatga aattagaaaa ataagaatga ggtcagtttt ttgacgaagc     60

taaatgattt ccttcaaaag actgtccatt attggagatt atattcttcc tacatttgtg    120

gcattaaaat gtcttttcca tctgggcatg gtggctcacg cctgtaatcc cagcactttg    180

ggaggccgag gcacaagaat cacttgaacc ctagaggcag aggttgcagt gagccgagat    240

cgcaccactg cattccagtc tggacgacaa agtgagactc catctcaaaa aaaaaaaaaa    300

aaaaaaaaaa aaggacaatg cctgagcaac attacctggg tcccctagcc cagcagggtt    360

ctccttg                                                              367


<210>  1345
<211>  47
<212>  PRT
<213>  Homo sapiens

<400>  1345


Met Ile Ser Phe Lys Arg Leu Ser Ile Ile Gly Asp Tyr Ile Leu Pro 
1               5                   10                  15      


Thr Phe Val Ala Leu Lys Cys Leu Phe His Leu Gly Met Val Ala His 
            20                  25                  30          


Ala Cys Asn Pro Ser Thr Leu Gly Gly Arg Gly Thr Arg Ile Thr 
        35                  40                  45          

<210>  1346
<211>  574
<212>  DNA
<213>  Homo sapiens

<400>  1346
acatctatta tctccagtta gcctaaaaac aacagcagaa gcagcagcaa caacgatgct     60

gagtgctgac tgcgagcctg gcttcctcgg agggagttta ccgtgcgctg cctccttgga    120

ccctcatcac tgccctgcga agcaagcact ttcctcaccc cctctgtctg gaggagggca    180

ctgaggcacc gagaaaactg ggcaggggag gcccgagaag gagagggtgg caccgtcatt    240

ctcactttcc agctgaggac acgggatgtg tacggcaccc gcatcccctc catctgcacc    300

cgcagccaca gccacagcca cagccagcgc tatgtcccgt tgccattcac attcatacct    360

gcaacgtaca ctcatacatg tgtcggatat ttgcgaagaa gctccctttc ccacctagag    420

atgggatctt gctctgttgt tcaggtggtg gtttcaaact cctggcctca agtgatcctc    480

ctgccttggc ctcccaaagc gctgggatta caggtgtgag ccgctgtgcc caggccaatc    540

ccagagattt tgatgatttc tcgatacgag tttc                                574


<210>  1347
<211>  64
<212>  PRT
<213>  Homo sapiens

<400>  1347


Met Cys Arg Ile Phe Ala Lys Lys Leu Pro Phe Pro Pro Arg Asp Gly 
1               5                   10                  15      


Ile Leu Leu Cys Cys Ser Gly Gly Gly Phe Lys Leu Leu Ala Ser Ser 
            20                  25                  30          


Asp Pro Pro Ala Leu Ala Ser Gln Ser Ala Gly Ile Thr Gly Val Ser 
        35                  40                  45              


Arg Cys Ala Gln Ala Asn Pro Arg Asp Phe Asp Asp Phe Ser Ile Arg 
    50                  55                  60                  

<210>  1348
<211>  678
<212>  DNA
<213>  Homo sapiens

<400>  1348
tggctgtact gagaagaggt cctgactcag aactggagga catcatggaa ggcttcctgg     60

aggaagtgcc atctaggctg aaacctaaag gatgagtaga actaaccaga tgaaaagcct    120

gagggatcta aagccttggg acttctggat ctgcaagtgg tccctgtttt ggtagctatt    180

gactgacgag gggctcttcg ccccacaggt gactgctgta gccttgagtg aggacctcgg    240

ccaaaaagaa ggctcctacc gtggctgttt gctgatggtc ttcgcagagc ctgctgtctt    300

tgagcttcct gagagaggga cactaccctc gcttaggtga gtgctccagg tccatggggc    360

ctgatgctct gtccctggtc tggcttccgc ccatgtatac atttgcactc ttgatggtgg    420

cttaggatct gcttccaaca agtctgccaa atgtgctctg taacacaggg ggaccctcca    480

aatgtgcatt gctttctgtc agtctcagga aacccattcc cttcccagcc tatctcagaa    540

acggagagtg gtggctcagt ggcctctggc tctggcacag ccccttgatg ggtccacagt    600

ggcccctctg cccttggctc tgttggcttc ccaacagatg ttcctcttca catgtagtcc    660

taagaactca atcagttt                                                  678


<210>  1349
<211>  64
<212>  PRT
<213>  Homo sapiens

<400>  1349


Met Cys Ile Ala Phe Cys Gln Ser Gln Glu Thr His Ser Leu Pro Ser 
1               5                   10                  15      


Leu Ser Gln Lys Arg Arg Val Val Ala Gln Trp Pro Leu Ala Leu Ala 
            20                  25                  30          


Gln Pro Leu Asp Gly Ser Thr Val Ala Pro Leu Pro Leu Ala Leu Leu 
        35                  40                  45              


Ala Ser Gln Gln Met Phe Leu Phe Thr Cys Ser Pro Lys Asn Ser Ile 
    50                  55                  60                  

<210>  1350
<211>  1091
<212>  DNA
<213>  Homo sapiens

<400>  1350
tggaggatgg agaataggct aaattgcaca ggccagctcc agtccattgg cagggctgcc     60

tagaacatgg ctgtgatgat cccaaagctc aatagcagag aaccctgtgg ggtgctagga    120

gtgtctgcca gggtgccgca gggaaagggg agcatgtgtg tagatgtaga aagcatctct    180

gccatcccct cccctaaaga atatataaca tggccatgca gaaaaacact tgtgaaagga    240

gctgctgccc tcaggacagc gtgtcattga aatgggggct gagcaacccg tcagaagagt    300

ggggaggagg gaccatcctc cagccccttc ccagctctct tctggagcca taagccacaa    360

cactgtctat gaaaaagctg aggcctagag cagaaggagt gcaaaatccc agctactgca    420

ggcctacgcc cagtggttct caaagtgttg tcctcagtct agcagcatca gtgtcacctg    480

aaaactggtt agacatccag gttctcagtt gttatccagc tctagcagat gggaaacgct    540

gggggcggga ccagccatct gtgtttaaca agccccacag gtgactgctg tagccttgag    600

tgaggacctc ggccaaaaag aaggctccta ccgtggctgt ttgctgatgg tcttcgcaga    660

gcctgctgtc tttgagcttc ctgagagagg gacactaccc tcgcttagcc tggcagtgtt    720

gcccaggagg aggcagtgga gttaagaagc ctgggtctga gctcctcagc tgtgcagaca    780

actcctactt gttcttcaac gctcaacttt aagttcagtc accacctgca gaagtcttct    840

ccaaaacctc cccacctggc tgactaaggg gctggcttta tgctcttgca gtactcatgc    900

ttcctactgt cacagttctg accacaccgt gggaaaacgt ctctaactag agacctgtct    960

tgcctcttgt gcctgtagta cgggatgggt gcccagtgtg tgttgattgt atgaatcaat   1020

ctctgtgact ccagagttcc tttcttcagg agattagaca tcacccctgc aatcaacaat   1080

gcaagccact g                                                        1091


<210>  1351
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  1351


Met Val Phe Ala Glu Pro Ala Val Phe Glu Leu Pro Glu Arg Gly Thr 
1               5                   10                  15      


Leu Pro Ser Leu Ser Leu Ala Val Leu Pro Arg Arg Arg Gln Trp Ser 
            20                  25                  30          

<210>  1352
<211>  3207
<212>  DNA
<213>  Homo sapiens

<400>  1352
cagcagacgg cagacggtgc ccggcgccca cgggaagctg aagatacagc ggtaaacaaa     60

cctccatgtc tcaagctgac cacacttgta tctggacttg ccagctgatt agctctgttc    120

ccaccaggct cgttcaaaga cccacagctt gagggggcag agggctgccc ctgatggggc    180

ctggcaatga ctgagcaggc ccagccccag aggacaagga agagaaggca tattgaggag    240

ggcaagaagt gacgcccggt gtagaatgac tgccctggga gggtggttcc ttgggccctg    300

gcagggttgc tgacccttac cctgcaaaac acaaagagca ggactccaga ctcttcttgt    360

gaatggtccc ctgccctgca gctccaccat gaggcttctc gtggccccac tcttgctagc    420

ttgggtggct ggtgccactg ccgctgtgcc cgtggtaccc tggcatgttc cctgcccccc    480

tcagtgtgcc tgccagatcc ggccctggta tacgccccgc tcgtcctacc gcgaggctac    540

cactgtggac tgcaatgacc tattcctgac ggcagtcccc ccggcactcc ccgcaggcac    600

acagaccctg ctcctgcaga gcaacagcat tgtccgtgtg gaccagagtg agctgggcta    660

cctggccaat ctcacagagc tggacctgtc ccagaacagc ttttcggatg cccgagactg    720

tgatttccat gccctgcccc agctgctgag cctgcaccta gaggagaacc agctgacccg    780

gctggaggac cacagctttg cagggctggc cagcctacag gaactctatc tcaaccacaa    840

ccagctctac cgcatcgccc ccagggcctt ttctggcctc agcaacttgc tgcggctgca    900

cctcaactcc aacctcctga gggccattga cagccgctgg tttgaaatgc tgcccaactt    960

ggagatactc atgattggcg gcaacaaggt agatgccatc ctggacatga acttccggcc   1020

cctggccaac ctgcgtagcc tggtgctagc aggcatgaac ctgcgggaga tctccgacta   1080

tgccctggag gggctgcaaa gcctggagag cctctccttc tatgacaacc agctggcccg   1140

ggtgcccagg cgggcactgg aacaggtgcc cgggctcaag ttcctagacc tcaacaagaa   1200

cccgctccag cgggtagggc cgggggactt tgccaacatg ctgcacctta aggagctggg   1260

actgaacaac atggaggagc tggtctccat cgacaagttt gccctggtga acctccccga   1320

gctgaccaag ctggacatca ccaataaccc acggctgtcc ttcatccacc cccgcgcctt   1380

ccaccacctg ccccagatgg agaccctcat gctcaacaac aacgctctca gtgccttgca   1440

ccagcagacg gtggagtccc tgcccaacct gcaggaggta ggtctccacg gcaaccccat   1500

ccgctgtgac tgtgtcatcc gctgggccaa tgccacgggc acccgtgtcc gcttcatcga   1560

gccgcaatcc accctgtgtg cggagcctcc ggacctccag cgcctcccgg tccgtgaggt   1620

gcccttccgg gagatgacgg accactgttt gcccctcatc tccccacgaa gcttcccccc   1680

aagcctccag gtagccagtg gagagagcat ggtgctgcat tgccgggcac tggccgaacc   1740

cgaacccgag atctactggg tcactccagc tgggcttcga ctgacacctg cccatgcagg   1800

caggaggtac cgggtgtacc ccgaggggac cctggagctg cggagggtga cagcagaaga   1860

ggcagggcta tacacctgtg tggcccagaa cctggtgggg gctgacacta agacggttag   1920

tgtggttgtg ggccgtgctc tcctccagcc aggcagggac gaaggacagg ggctggagct   1980

ccgggtgcag gagacccacc cctatcacat cctgctatct tgggtcaccc cacccaacac   2040

agtgtccacc aacctcacct ggtccagtgc ctcctccctc cggggccagg gggccacagc   2100

tctggcccgc ctgcctcggg gaacccacag ctacaacatt acccgcctcc ttcaggccac   2160

ggagtactgg gcctgcctgc aagtggcctt tgctgatgcc cacacccagt tggcttgtgt   2220

atgggccagg accaaagagg ccacttcttg ccacagagcc ttaggggacc gtcctgggct   2280

cattgccatc ctggctctcg ctgtccttct cctggcagct gggctagcgg cccaccttgg   2340

cacaggccaa cccaggaagg gtgtgggtgg gaggcggcct ctccctccag cctgggcttt   2400

ctggggctgg agtgcccctt ctgtccgggt tgtgtctgct cccctcgtcc tgccctggaa   2460

tccagggagg aagctgccca gatcctcaga aggggagaca ctgttgccac cattgtctca   2520

aaattcttga agctcagcct gttctcagca gtagagaaat cactaggact actttttacc   2580

aaaagagaag cagtctgggc cagatgccct gccaggaaag ggacatggac ccacgtgctt   2640

gaggcctggc agctgggcca agacagatgg ggctttgtgg ccctgggggt gcttctgcag   2700

cctcgaaaaa gttgccctta cctcctaggg tcacctctgc tgccattctg aggaacatct   2760

ccaaggaaca ggagggactt tggctagagc ctcctgcctc cccatcttct ctctgcccag   2820

aggctcctgg gcctggcttg gctgtcccct acctgtgtcc ccgggctgca ccccttcctc   2880

ttctctttct ctgtacagtc tcagttgctt gctcttgtgc ctcctgggca agggctgaag   2940

gaggccactc catctcacct cggggggctg ccctcaatgt gggagtgacc ccagccagat   3000

ctgaaggaca tttgggagag ggatgcccag gaacgcctca tctcagcagc ctgggctcgg   3060

cattccgaag ctgactttct ataggcaatt ttgtaccttt gtggagaaat gtgtcacctc   3120

ccccaacccg attcactctt ttctcctgtt ttgtaaaaaa taaaaataaa taataacaat   3180

aatacggggg aaaggaacga aaggaaa                                       3207


<210>  1353
<211>  713
<212>  PRT
<213>  Homo sapiens

<400>  1353


Met Arg Leu Leu Val Ala Pro Leu Leu Leu Ala Trp Val Ala Gly Ala 
1               5                   10                  15      


Thr Ala Ala Val Pro Val Val Pro Trp His Val Pro Cys Pro Pro Gln 
            20                  25                  30          


Cys Ala Cys Gln Ile Arg Pro Trp Tyr Thr Pro Arg Ser Ser Tyr Arg 
        35                  40                  45              


Glu Ala Thr Thr Val Asp Cys Asn Asp Leu Phe Leu Thr Ala Val Pro 
    50                  55                  60                  


Pro Ala Leu Pro Ala Gly Thr Gln Thr Leu Leu Leu Gln Ser Asn Ser 
65                  70                  75                  80  


Ile Val Arg Val Asp Gln Ser Glu Leu Gly Tyr Leu Ala Asn Leu Thr 
                85                  90                  95      


Glu Leu Asp Leu Ser Gln Asn Ser Phe Ser Asp Ala Arg Asp Cys Asp 
            100                 105                 110         


Phe His Ala Leu Pro Gln Leu Leu Ser Leu His Leu Glu Glu Asn Gln 
        115                 120                 125             


Leu Thr Arg Leu Glu Asp His Ser Phe Ala Gly Leu Ala Ser Leu Gln 
    130                 135                 140                 


Glu Leu Tyr Leu Asn His Asn Gln Leu Tyr Arg Ile Ala Pro Arg Ala 
145                 150                 155                 160 


Phe Ser Gly Leu Ser Asn Leu Leu Arg Leu His Leu Asn Ser Asn Leu 
                165                 170                 175     


Leu Arg Ala Ile Asp Ser Arg Trp Phe Glu Met Leu Pro Asn Leu Glu 
            180                 185                 190         


Ile Leu Met Ile Gly Gly Asn Lys Val Asp Ala Ile Leu Asp Met Asn 
        195                 200                 205             


Phe Arg Pro Leu Ala Asn Leu Arg Ser Leu Val Leu Ala Gly Met Asn 
    210                 215                 220                 


Leu Arg Glu Ile Ser Asp Tyr Ala Leu Glu Gly Leu Gln Ser Leu Glu 
225                 230                 235                 240 


Ser Leu Ser Phe Tyr Asp Asn Gln Leu Ala Arg Val Pro Arg Arg Ala 
                245                 250                 255     


Leu Glu Gln Val Pro Gly Leu Lys Phe Leu Asp Leu Asn Lys Asn Pro 
            260                 265                 270         


Leu Gln Arg Val Gly Pro Gly Asp Phe Ala Asn Met Leu His Leu Lys 
        275                 280                 285             


Glu Leu Gly Leu Asn Asn Met Glu Glu Leu Val Ser Ile Asp Lys Phe 
    290                 295                 300                 


Ala Leu Val Asn Leu Pro Glu Leu Thr Lys Leu Asp Ile Thr Asn Asn 
305                 310                 315                 320 


Pro Arg Leu Ser Phe Ile His Pro Arg Ala Phe His His Leu Pro Gln 
                325                 330                 335     


Met Glu Thr Leu Met Leu Asn Asn Asn Ala Leu Ser Ala Leu His Gln 
            340                 345                 350         


Gln Thr Val Glu Ser Leu Pro Asn Leu Gln Glu Val Gly Leu His Gly 
        355                 360                 365             


Asn Pro Ile Arg Cys Asp Cys Val Ile Arg Trp Ala Asn Ala Thr Gly 
    370                 375                 380                 


Thr Arg Val Arg Phe Ile Glu Pro Gln Ser Thr Leu Cys Ala Glu Pro 
385                 390                 395                 400 


Pro Asp Leu Gln Arg Leu Pro Val Arg Glu Val Pro Phe Arg Glu Met 
                405                 410                 415     


Thr Asp His Cys Leu Pro Leu Ile Ser Pro Arg Ser Phe Pro Pro Ser 
            420                 425                 430         


Leu Gln Val Ala Ser Gly Glu Ser Met Val Leu His Cys Arg Ala Leu 
        435                 440                 445             


Ala Glu Pro Glu Pro Glu Ile Tyr Trp Val Thr Pro Ala Gly Leu Arg 
    450                 455                 460                 


Leu Thr Pro Ala His Ala Gly Arg Arg Tyr Arg Val Tyr Pro Glu Gly 
465                 470                 475                 480 


Thr Leu Glu Leu Arg Arg Val Thr Ala Glu Glu Ala Gly Leu Tyr Thr 
                485                 490                 495     


Cys Val Ala Gln Asn Leu Val Gly Ala Asp Thr Lys Thr Val Ser Val 
            500                 505                 510         


Val Val Gly Arg Ala Leu Leu Gln Pro Gly Arg Asp Glu Gly Gln Gly 
        515                 520                 525             


Leu Glu Leu Arg Val Gln Glu Thr His Pro Tyr His Ile Leu Leu Ser 
    530                 535                 540                 


Trp Val Thr Pro Pro Asn Thr Val Ser Thr Asn Leu Thr Trp Ser Ser 
545                 550                 555                 560 


Ala Ser Ser Leu Arg Gly Gln Gly Ala Thr Ala Leu Ala Arg Leu Pro 
                565                 570                 575     


Arg Gly Thr His Ser Tyr Asn Ile Thr Arg Leu Leu Gln Ala Thr Glu 
            580                 585                 590         


Tyr Trp Ala Cys Leu Gln Val Ala Phe Ala Asp Ala His Thr Gln Leu 
        595                 600                 605             


Ala Cys Val Trp Ala Arg Thr Lys Glu Ala Thr Ser Cys His Arg Ala 
    610                 615                 620                 


Leu Gly Asp Arg Pro Gly Leu Ile Ala Ile Leu Ala Leu Ala Val Leu 
625                 630                 635                 640 


Leu Leu Ala Ala Gly Leu Ala Ala His Leu Gly Thr Gly Gln Pro Arg 
                645                 650                 655     


Lys Gly Val Gly Gly Arg Arg Pro Leu Pro Pro Ala Trp Ala Phe Trp 
            660                 665                 670         


Gly Trp Ser Ala Pro Ser Val Arg Val Val Ser Ala Pro Leu Val Leu 
        675                 680                 685             


Pro Trp Asn Pro Gly Arg Lys Leu Pro Arg Ser Ser Glu Gly Glu Thr 
    690                 695                 700                 


Leu Leu Pro Pro Leu Ser Gln Asn Ser 
705                 710             

<210>  1354
<211>  3442
<212>  DNA
<213>  Homo sapiens

<400>  1354
gcgagtgagg agggcgagcg cgaagccggg aagaggggcg cgcgtggagg gggtgccggg     60

cgccgcgagg gcctgctccg ggcacctgcg aacgcgcggc gctctcaagg agcgcctggc    120

tctcgcccgc cagcctccgg ccgcgacgcg cccagggcgc ggagaggggg tggggacgga    180

ttgggattct gccatcgccc tcaccggctg ggccctggag ccgctcccag gataactcca    240

cgttggggag ggcgcccgcc gagcctcccc ggcctgtgca gacggcgcgc gcggcgggag    300

ggcgcggacc agcgtcccca gcccggcccc gggcggaagg cgagcggagc gcggccgcgc    360

gggcagcaga cggcagacgg tgcccggcgc ccacgggggc tgcccctgat ggggcctggc    420

aatgactgag caggcccagc cccagaggac aaggaagaga aggcatattg aggagggcaa    480

gaagtgacgc ccggtgtaga atgactgccc tgggagggtg gttccttggg ccctggcagg    540

gttgctgacc cttaccctgc aaaacacaaa gagcaggact ccagactctt cttgtgaatg    600

gtcccctgcc ctgcagctcc accatgaggc ttctcgtggc cccactcttg ctagcttggg    660

tggctggtgc cactgccgct gtgcccgtgg taccctggca tgttccctgc ccccctcagt    720

gtgcctgcca gatccggccc tggtatacgc cccgctcgtc ctaccgcgag gctaccactg    780

tggactgcaa tgacctattc ctgacggcag tccccccggc actccccgca ggcacacaga    840

ccctgctcct gcagagcaac agcattgtcc gtgtggacca gagtgagctg ggctacctgg    900

ccaatctcac agagctggac ctgtcccaga acagcttttc ggatgcccga gactgtgatt    960

tccatgccct gccccagctg ctgagcctgc acctagagga gaaccagctg acccggctgg   1020

aggaccacag ctttgcaggg ctggccagcc tacaggaact ctatctcaac cacaaccagc   1080

tctaccgcat cgcccccagg gccttttctg gcctcagcaa cttgctgcgg ctgcacctca   1140

actccaacct cctgagggcc attgacagcc gctggtttga aatgctgccc aacttggaga   1200

tactcatgat tggcggcaac aaggtagatg ccatcctgga catgaacttc cggcccctgg   1260

ccaacctgcg tagcctggtg ctagcaggca tgaacctgcg ggagatctcc gactatgccc   1320

tggaggggct gcaaagcctg gagagcctct ccttctatga caaccagctg gcccgggtgc   1380

ccaggcgggc actggaacag gtgcccgggc tcaagttcct agacctcaac aagaacccgc   1440

tccagcgggt agggccgggg gactttgcca acatgctgca ccttaaggag ctgggactga   1500

acaacatgga ggagctggtc tccatcgaca agtttgccct ggtgaacctc cccgagctga   1560

ccaagctgga catcaccaat aacccacggc tgtccttcat ccacccccgc gccttccacc   1620

acctgcccca gatggagacc ctcatgctca acaacaacgc tctcagtgcc ttgcaccagc   1680

agacggtgga gtccctgccc aacctgcagg aggtaggtct ccacggcaac cccatccgct   1740

gtgactgtgt catccgctgg gccaatgcca cgggcacccg tgtccgcttc atcgagccgc   1800

aatccaccct gtgtgcggag cctccggacc tccagcgcct cccggtccgt gaggtgccct   1860

tccgggagat gacggaccac tgtttgcccc tcatctcccc acgaagcttc cccccaagcc   1920

tccaggtagc cagtggagag agcatggtgc tgcattgccg ggcactggcc gaacccgaac   1980

ccgagatcta ctgggtcact ccagctgggc ttcgactgac acctgcccat gcaggcagga   2040

ggtaccgggt gtaccccgag gggaccctgg agctgcggag ggtgacagca gaagaggcag   2100

ggctatacac ctgtgtggcc cagaacctgg tgggggctga cactaagacg gttagtgtgg   2160

ttgtgggccg tgctctcctc cagccaggca gggacgaagg acaggggctg gagctccggg   2220

tgcaggagac ccacccctat cacatcctgc tatcttgggt caccccaccc aacacagtgt   2280

ccaccaacct cacctggtcc agtgcctcct ccctccgggg ccagggggcc acagctctgg   2340

cccgcctgcc tcggggaacc cacagctaca acattacccg cctccttcag gccacggagt   2400

actgggcctg cctgcaagtg gcctttgctg atgcccacac ccagttggct tgtgtatggg   2460

ccaggaccaa agaggccact tcttgccaca gagccttagg ggaccgtcct gggctcattg   2520

ccatcctggc tctcgctgtc cttctcctgg cagctgggct agcggcccac cttggcacag   2580

gccaacccag gaagggtgtg ggtgggaggc ggcctctccc tccagcctgg gctttctggg   2640

gctggagtgc cccttctgtc cgggttgtgt ctgctcccct cgtcctgccc tggaatccag   2700

ggaggaagct gcccagatcc tcagaagggg agacactgtt gccaccattg tctcaaaatt   2760

cttgaagctc agcctgttct cagcagtaga gaaatcacta ggactacttt ttaccaaaag   2820

agaagcagtc tgggccagat gccctgccag gaaagggaca tggacccacg tgcttgaggc   2880

ctggcagctg ggccaagaca gatggggctt tgtggccctg ggggtgcttc tgcagcctcg   2940

aaaaagttgc ccttacctcc tagggtcacc tctgctgcca ttctgaggaa catctccaag   3000

gaacaggagg gactttggct agagcctcct gcctccccat cttctctctg cccagaggct   3060

cctgggcctg gcttggctgt cccctacctg tgtccccggg ctgcacccct tcctcttctc   3120

tttctctgta cagtctcagt tgcttgctct tgtgcctcct gggcaagggc tgaaggaggc   3180

cactccatct cacctcgggg ggctgccctc aatgtgggag tgaccccagc cagatctgaa   3240

ggacatttgg gagagggatg cccaggaacg cctcatctca gcagcctggg ctcggcattc   3300

cgaagctgac tttctatagg caattttgta cctttgtgga gaaatgtgtc acctccccca   3360

acccgattca ctcttttctc ctgttttgta aaaaataaaa ataaataata acaataatac   3420

gggggaaagg aacgaaagga aa                                            3442


<210>  1355
<211>  713
<212>  PRT
<213>  Homo sapiens

<400>  1355


Met Arg Leu Leu Val Ala Pro Leu Leu Leu Ala Trp Val Ala Gly Ala 
1               5                   10                  15      


Thr Ala Ala Val Pro Val Val Pro Trp His Val Pro Cys Pro Pro Gln 
            20                  25                  30          


Cys Ala Cys Gln Ile Arg Pro Trp Tyr Thr Pro Arg Ser Ser Tyr Arg 
        35                  40                  45              


Glu Ala Thr Thr Val Asp Cys Asn Asp Leu Phe Leu Thr Ala Val Pro 
    50                  55                  60                  


Pro Ala Leu Pro Ala Gly Thr Gln Thr Leu Leu Leu Gln Ser Asn Ser 
65                  70                  75                  80  


Ile Val Arg Val Asp Gln Ser Glu Leu Gly Tyr Leu Ala Asn Leu Thr 
                85                  90                  95      


Glu Leu Asp Leu Ser Gln Asn Ser Phe Ser Asp Ala Arg Asp Cys Asp 
            100                 105                 110         


Phe His Ala Leu Pro Gln Leu Leu Ser Leu His Leu Glu Glu Asn Gln 
        115                 120                 125             


Leu Thr Arg Leu Glu Asp His Ser Phe Ala Gly Leu Ala Ser Leu Gln 
    130                 135                 140                 


Glu Leu Tyr Leu Asn His Asn Gln Leu Tyr Arg Ile Ala Pro Arg Ala 
145                 150                 155                 160 


Phe Ser Gly Leu Ser Asn Leu Leu Arg Leu His Leu Asn Ser Asn Leu 
                165                 170                 175     


Leu Arg Ala Ile Asp Ser Arg Trp Phe Glu Met Leu Pro Asn Leu Glu 
            180                 185                 190         


Ile Leu Met Ile Gly Gly Asn Lys Val Asp Ala Ile Leu Asp Met Asn 
        195                 200                 205             


Phe Arg Pro Leu Ala Asn Leu Arg Ser Leu Val Leu Ala Gly Met Asn 
    210                 215                 220                 


Leu Arg Glu Ile Ser Asp Tyr Ala Leu Glu Gly Leu Gln Ser Leu Glu 
225                 230                 235                 240 


Ser Leu Ser Phe Tyr Asp Asn Gln Leu Ala Arg Val Pro Arg Arg Ala 
                245                 250                 255     


Leu Glu Gln Val Pro Gly Leu Lys Phe Leu Asp Leu Asn Lys Asn Pro 
            260                 265                 270         


Leu Gln Arg Val Gly Pro Gly Asp Phe Ala Asn Met Leu His Leu Lys 
        275                 280                 285             


Glu Leu Gly Leu Asn Asn Met Glu Glu Leu Val Ser Ile Asp Lys Phe 
    290                 295                 300                 


Ala Leu Val Asn Leu Pro Glu Leu Thr Lys Leu Asp Ile Thr Asn Asn 
305                 310                 315                 320 


Pro Arg Leu Ser Phe Ile His Pro Arg Ala Phe His His Leu Pro Gln 
                325                 330                 335     


Met Glu Thr Leu Met Leu Asn Asn Asn Ala Leu Ser Ala Leu His Gln 
            340                 345                 350         


Gln Thr Val Glu Ser Leu Pro Asn Leu Gln Glu Val Gly Leu His Gly 
        355                 360                 365             


Asn Pro Ile Arg Cys Asp Cys Val Ile Arg Trp Ala Asn Ala Thr Gly 
    370                 375                 380                 


Thr Arg Val Arg Phe Ile Glu Pro Gln Ser Thr Leu Cys Ala Glu Pro 
385                 390                 395                 400 


Pro Asp Leu Gln Arg Leu Pro Val Arg Glu Val Pro Phe Arg Glu Met 
                405                 410                 415     


Thr Asp His Cys Leu Pro Leu Ile Ser Pro Arg Ser Phe Pro Pro Ser 
            420                 425                 430         


Leu Gln Val Ala Ser Gly Glu Ser Met Val Leu His Cys Arg Ala Leu 
        435                 440                 445             


Ala Glu Pro Glu Pro Glu Ile Tyr Trp Val Thr Pro Ala Gly Leu Arg 
    450                 455                 460                 


Leu Thr Pro Ala His Ala Gly Arg Arg Tyr Arg Val Tyr Pro Glu Gly 
465                 470                 475                 480 


Thr Leu Glu Leu Arg Arg Val Thr Ala Glu Glu Ala Gly Leu Tyr Thr 
                485                 490                 495     


Cys Val Ala Gln Asn Leu Val Gly Ala Asp Thr Lys Thr Val Ser Val 
            500                 505                 510         


Val Val Gly Arg Ala Leu Leu Gln Pro Gly Arg Asp Glu Gly Gln Gly 
        515                 520                 525             


Leu Glu Leu Arg Val Gln Glu Thr His Pro Tyr His Ile Leu Leu Ser 
    530                 535                 540                 


Trp Val Thr Pro Pro Asn Thr Val Ser Thr Asn Leu Thr Trp Ser Ser 
545                 550                 555                 560 


Ala Ser Ser Leu Arg Gly Gln Gly Ala Thr Ala Leu Ala Arg Leu Pro 
                565                 570                 575     


Arg Gly Thr His Ser Tyr Asn Ile Thr Arg Leu Leu Gln Ala Thr Glu 
            580                 585                 590         


Tyr Trp Ala Cys Leu Gln Val Ala Phe Ala Asp Ala His Thr Gln Leu 
        595                 600                 605             


Ala Cys Val Trp Ala Arg Thr Lys Glu Ala Thr Ser Cys His Arg Ala 
    610                 615                 620                 


Leu Gly Asp Arg Pro Gly Leu Ile Ala Ile Leu Ala Leu Ala Val Leu 
625                 630                 635                 640 


Leu Leu Ala Ala Gly Leu Ala Ala His Leu Gly Thr Gly Gln Pro Arg 
                645                 650                 655     


Lys Gly Val Gly Gly Arg Arg Pro Leu Pro Pro Ala Trp Ala Phe Trp 
            660                 665                 670         


Gly Trp Ser Ala Pro Ser Val Arg Val Val Ser Ala Pro Leu Val Leu 
        675                 680                 685             


Pro Trp Asn Pro Gly Arg Lys Leu Pro Arg Ser Ser Glu Gly Glu Thr 
    690                 695                 700                 


Leu Leu Pro Pro Leu Ser Gln Asn Ser 
705                 710             

<210>  1356
<211>  3545
<212>  DNA
<213>  Homo sapiens

<400>  1356
gcgagtgagg agggcgagcg cgaagccggg aagaggggcg cgcgtggagg gggtgccggg     60

cgccgcgagg gcctgctccg ggcacctgcg aacgcgcggc gctctcaagg agcgcctggc    120

tctcgcccgc cagcctccgg ccgcgacgcg cccagggcgc ggagaggggg tggggacgga    180

ttgggattct gccatcgccc tcaccggctg ggccctggag ccgctcccag gataactcca    240

cgttggggag ggcgcccgcc gagcctcccc ggcctgtgca gacggcgcgc gcggcgggag    300

ggcgcggacc agcgtcccca gcccggcccc gggcggaagg cgagcggagc gcggccgcgc    360

gggcagcaga cggcagacgg tgcccggcgc ccacgggggg tgatgtctaa tctcctgaag    420

aaaggaactc tggagtcaca gagattgatt catacaatca acacacactg ggcacccatc    480

ccgtactaca ggcacaagag ggctgcccct gatggggcct ggcaatgact gagcaggccc    540

agccccagag gacaaggaag agaaggcata ttgaggaggg caagaagtga cgcccggtgt    600

agaatgactg ccctgggagg gtggttcctt gggccctggc agggttgctg acccttaccc    660

tgcaaaacac aaagagcagg actccagact cttcttgtga atggtcccct gccctgcagc    720

tccaccatga ggcttctcgt ggccccactc ttgctagctt gggtggctgg tgccactgcc    780

gctgtgcccg tggtaccctg gcatgttccc tgcccccctc agtgtgcctg ccagatccgg    840

ccctggtata cgccccgctc gtcctaccgc gaggctacca ctgtggactg caatgaccta    900

ttcctgacgg cagtcccccc ggcactcccc gcaggcacac agaccctgct cctgcagagc    960

aacagcattg tccgtgtgga ccagagtgag ctgggctacc tggccaatct cacagagctg   1020

gacctgtccc agaacagctt ttcggatgcc cgagactgtg atttccatgc cctgccccag   1080

ctgctgagcc tgcacctaga ggagaaccag ctgacccggc tggaggacca cagctttgca   1140

gggctggcca gcctacagga actctatctc aaccacaacc agctctaccg catcgccccc   1200

agggcctttt ctggcctcag caacttgctg cggctgcacc tcaactccaa cctcctgagg   1260

gccattgaca gccgctggtt tgaaatgctg cccaacttgg agatactcat gattggcggc   1320

aacaaggtag atgccatcct ggacatgaac ttccggcccc tggccaacct gcgtagcctg   1380

gtgctagcag gcatgaacct gcgggagatc tccgactatg ccctggaggg gctgcaaagc   1440

ctggagagcc tctccttcta tgacaaccag ctggcccggg tgcccaggcg ggcactggaa   1500

caggtgcccg ggctcaagtt cctagacctc aacaagaacc cgctccagcg ggtagggccg   1560

ggggactttg ccaacatgct gcaccttaag gagctgggac tgaacaacat ggaggagctg   1620

gtctccatcg acaagtttgc cctggtgaac ctccccgagc tgaccaagct ggacatcacc   1680

aataacccac ggctgtcctt catccacccc cgcgccttcc accacctgcc ccagatggag   1740

accctcatgc tcaacaacaa cgctctcagt gccttgcacc agcagacggt ggagtccctg   1800

cccaacctgc aggaggtagg tctccacggc aaccccatcc gctgtgactg tgtcatccgc   1860

tgggccaatg ccacgggcac ccgtgtccgc ttcatcgagc cgcaatccac cctgtgtgcg   1920

gagcctccgg acctccagcg cctcccggtc cgtgaggtgc ccttccggga gatgacggac   1980

cactgtttgc ccctcatctc cccacgaagc ttccccccaa gcctccaggt agccagtgga   2040

gagagcatgg tgctgcattg ccgggcactg gccgaacccg aacccgagat ctactgggtc   2100

actccagctg ggcttcgact gacacctgcc catgcaggca ggaggtaccg ggtgtacccc   2160

gaggggaccc tggagctgcg gagggtgaca gcagaagagg cagggctata cacctgtgtg   2220

gcccagaacc tggtgggggc tgacactaag acggttagtg tggttgtggg ccgtgctctc   2280

ctccagccag gcagggacga aggacagggg ctggagctcc gggtgcagga gacccacccc   2340

tatcacatcc tgctatcttg ggtcacccca cccaacacag tgtccaccaa cctcacctgg   2400

tccagtgcct cctccctccg gggccagggg gccacagctc tggcccgcct gcctcgggga   2460

acccacagct acaacattac ccgcctcctt caggccacgg agtactgggc ctgcctgcaa   2520

gtggcctttg ctgatgccca cacccagttg gcttgtgtat gggccaggac caaagaggcc   2580

acttcttgcc acagagcctt aggggaccgt cctgggctca ttgccatcct ggctctcgct   2640

gtccttctcc tggcagctgg gctagcggcc caccttggca caggccaacc caggaagggt   2700

gtgggtggga ggcggcctct ccctccagcc tgggctttct ggggctggag tgccccttct   2760

gtccgggttg tgtctgctcc cctcgtcctg ccctggaatc cagggaggaa gctgcccaga   2820

tcctcagaag gggagacact gttgccacca ttgtctcaaa attcttgaag ctcagcctgt   2880

tctcagcagt agagaaatca ctaggactac tttttaccaa aagagaagca gtctgggcca   2940

gatgccctgc caggaaaggg acatggaccc acgtgcttga ggcctggcag ctgggccaag   3000

acagatgggg ctttgtggcc ctgggggtgc ttctgcagcc tcgaaaaagt tgcccttacc   3060

tcctagggtc acctctgctg ccattctgag gaacatctcc aaggaacagg agggactttg   3120

gctagagcct cctgcctccc catcttctct ctgcccagag gctcctgggc ctggcttggc   3180

tgtcccctac ctgtgtcccc gggctgcacc ccttcctctt ctctttctct gtacagtctc   3240

agttgcttgc tcttgtgcct cctgggcaag ggctgaagga ggccactcca tctcacctcg   3300

gggggctgcc ctcaatgtgg gagtgacccc agccagatct gaaggacatt tgggagaggg   3360

atgcccagga acgcctcatc tcagcagcct gggctcggca ttccgaagct gactttctat   3420

aggcaatttt gtacctttgt ggagaaatgt gtcacctccc ccaacccgat tcactctttt   3480

ctcctgtttt gtaaaaaata aaaataaata ataacaataa tacgggggaa aggaacgaaa   3540

ggaaa                                                               3545


<210>  1357
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  1357


Met Ser Asn Leu Leu Lys Lys Gly Thr Leu Glu Ser Gln Arg Leu Ile 
1               5                   10                  15      


His Thr Ile Asn Thr His Trp Ala Pro Ile Pro Tyr Tyr Arg His Lys 
            20                  25                  30          


Arg Ala Ala Pro Asp Gly Ala Trp Gln 
        35                  40      

<210>  1358
<211>  3545
<212>  DNA
<213>  Homo sapiens

<400>  1358
gcgagtgagg agggcgagcg cgaagccggg aagaggggcg cgcgtggagg gggtgccggg     60

cgccgcgagg gcctgctccg ggcacctgcg aacgcgcggc gctctcaagg agcgcctggc    120

tctcgcccgc cagcctccgg ccgcgacgcg cccagggcgc ggagaggggg tggggacgga    180

ttgggattct gccatcgccc tcaccggctg ggccctggag ccgctcccag gataactcca    240

cgttggggag ggcgcccgcc gagcctcccc ggcctgtgca gacggcgcgc gcggcgggag    300

ggcgcggacc agcgtcccca gcccggcccc gggcggaagg cgagcggagc gcggccgcgc    360

gggcagcaga cggcagacgg tgcccggcgc ccacgggttc tggaggctgg gaagtccaag    420

acaaggtgcc agcatctggt gaaggctgct gtctgctttc aagatggtgc ctcgaatgct    480

gtttcctcac atggcagaag ggctgcccct gatggggcct ggcaatgact gagcaggccc    540

agccccagag gacaaggaag agaaggcata ttgaggaggg caagaagtga cgcccggtgt    600

agaatgactg ccctgggagg gtggttcctt gggccctggc agggttgctg acccttaccc    660

tgcaaaacac aaagagcagg actccagact cttcttgtga atggtcccct gccctgcagc    720

tccaccatga ggcttctcgt ggccccactc ttgctagctt gggtggctgg tgccactgcc    780

gctgtgcccg tggtaccctg gcatgttccc tgcccccctc agtgtgcctg ccagatccgg    840

ccctggtata cgccccgctc gtcctaccgc gaggctacca ctgtggactg caatgaccta    900

ttcctgacgg cagtcccccc ggcactcccc gcaggcacac agaccctgct cctgcagagc    960

aacagcattg tccgtgtgga ccagagtgag ctgggctacc tggccaatct cacagagctg   1020

gacctgtccc agaacagctt ttcggatgcc cgagactgtg atttccatgc cctgccccag   1080

ctgctgagcc tgcacctaga ggagaaccag ctgacccggc tggaggacca cagctttgca   1140

gggctggcca gcctacagga actctatctc aaccacaacc agctctaccg catcgccccc   1200

agggcctttt ctggcctcag caacttgctg cggctgcacc tcaactccaa cctcctgagg   1260

gccattgaca gccgctggtt tgaaatgctg cccaacttgg agatactcat gattggcggc   1320

aacaaggtag atgccatcct ggacatgaac ttccggcccc tggccaacct gcgtagcctg   1380

gtgctagcag gcatgaacct gcgggagatc tccgactatg ccctggaggg gctgcaaagc   1440

ctggagagcc tctccttcta tgacaaccag ctggcccggg tgcccaggcg ggcactggaa   1500

caggtgcccg ggctcaagtt cctagacctc aacaagaacc cgctccagcg ggtagggccg   1560

ggggactttg ccaacatgct gcaccttaag gagctgggac tgaacaacat ggaggagctg   1620

gtctccatcg acaagtttgc cctggtgaac ctccccgagc tgaccaagct ggacatcacc   1680

aataacccac ggctgtcctt catccacccc cgcgccttcc accacctgcc ccagatggag   1740

accctcatgc tcaacaacaa cgctctcagt gccttgcacc agcagacggt ggagtccctg   1800

cccaacctgc aggaggtagg tctccacggc aaccccatcc gctgtgactg tgtcatccgc   1860

tgggccaatg ccacgggcac ccgtgtccgc ttcatcgagc cgcaatccac cctgtgtgcg   1920

gagcctccgg acctccagcg cctcccggtc cgtgaggtgc ccttccggga gatgacggac   1980

cactgtttgc ccctcatctc cccacgaagc ttccccccaa gcctccaggt agccagtgga   2040

gagagcatgg tgctgcattg ccgggcactg gccgaacccg aacccgagat ctactgggtc   2100

actccagctg ggcttcgact gacacctgcc catgcaggca ggaggtaccg ggtgtacccc   2160

gaggggaccc tggagctgcg gagggtgaca gcagaagagg cagggctata cacctgtgtg   2220

gcccagaacc tggtgggggc tgacactaag acggttagtg tggttgtggg ccgtgctctc   2280

ctccagccag gcagggacga aggacagggg ctggagctcc gggtgcagga gacccacccc   2340

tatcacatcc tgctatcttg ggtcacccca cccaacacag tgtccaccaa cctcacctgg   2400

tccagtgcct cctccctccg gggccagggg gccacagctc tggcccgcct gcctcgggga   2460

acccacagct acaacattac ccgcctcctt caggccacgg agtactgggc ctgcctgcaa   2520

gtggcctttg ctgatgccca cacccagttg gcttgtgtat gggccaggac caaagaggcc   2580

acttcttgcc acagagcctt aggggaccgt cctgggctca ttgccatcct ggctctcgct   2640

gtccttctcc tggcagctgg gctagcggcc caccttggca caggccaacc caggaagggt   2700

gtgggtggga ggcggcctct ccctccagcc tgggctttct ggggctggag tgccccttct   2760

gtccgggttg tgtctgctcc cctcgtcctg ccctggaatc cagggaggaa gctgcccaga   2820

tcctcagaag gggagacact gttgccacca ttgtctcaaa attcttgaag ctcagcctgt   2880

tctcagcagt agagaaatca ctaggactac tttttaccaa aagagaagca gtctgggcca   2940

gatgccctgc caggaaaggg acatggaccc acgtgcttga ggcctggcag ctgggccaag   3000

acagatgggg ctttgtggcc ctgggggtgc ttctgcagcc tcgaaaaagt tgcccttacc   3060

tcctagggtc acctctgctg ccattctgag gaacatctcc aaggaacagg agggactttg   3120

gctagagcct cctgcctccc catcttctct ctgcccagag gctcctgggc ctggcttggc   3180

tgtcccctac ctgtgtcccc gggctgcacc ccttcctctt ctctttctct gtacagtctc   3240

agttgcttgc tcttgtgcct cctgggcaag ggctgaagga ggccactcca tctcacctcg   3300

gggggctgcc ctcaatgtgg gagtgacccc agccagatct gaaggacatt tgggagaggg   3360

atgcccagga acgcctcatc tcagcagcct gggctcggca ttccgaagct gactttctat   3420

aggcaatttt gtacctttgt ggagaaatgt gtcacctccc ccaacccgat tcactctttt   3480

ctcctgtttt gtaaaaaata aaaataaata ataacaataa tacgggggaa aggaacgaaa   3540

ggaaa                                                               3545


<210>  1359
<211>  713
<212>  PRT
<213>  Homo sapiens

<400>  1359


Met Arg Leu Leu Val Ala Pro Leu Leu Leu Ala Trp Val Ala Gly Ala 
1               5                   10                  15      


Thr Ala Ala Val Pro Val Val Pro Trp His Val Pro Cys Pro Pro Gln 
            20                  25                  30          


Cys Ala Cys Gln Ile Arg Pro Trp Tyr Thr Pro Arg Ser Ser Tyr Arg 
        35                  40                  45              


Glu Ala Thr Thr Val Asp Cys Asn Asp Leu Phe Leu Thr Ala Val Pro 
    50                  55                  60                  


Pro Ala Leu Pro Ala Gly Thr Gln Thr Leu Leu Leu Gln Ser Asn Ser 
65                  70                  75                  80  


Ile Val Arg Val Asp Gln Ser Glu Leu Gly Tyr Leu Ala Asn Leu Thr 
                85                  90                  95      


Glu Leu Asp Leu Ser Gln Asn Ser Phe Ser Asp Ala Arg Asp Cys Asp 
            100                 105                 110         


Phe His Ala Leu Pro Gln Leu Leu Ser Leu His Leu Glu Glu Asn Gln 
        115                 120                 125             


Leu Thr Arg Leu Glu Asp His Ser Phe Ala Gly Leu Ala Ser Leu Gln 
    130                 135                 140                 


Glu Leu Tyr Leu Asn His Asn Gln Leu Tyr Arg Ile Ala Pro Arg Ala 
145                 150                 155                 160 


Phe Ser Gly Leu Ser Asn Leu Leu Arg Leu His Leu Asn Ser Asn Leu 
                165                 170                 175     


Leu Arg Ala Ile Asp Ser Arg Trp Phe Glu Met Leu Pro Asn Leu Glu 
            180                 185                 190         


Ile Leu Met Ile Gly Gly Asn Lys Val Asp Ala Ile Leu Asp Met Asn 
        195                 200                 205             


Phe Arg Pro Leu Ala Asn Leu Arg Ser Leu Val Leu Ala Gly Met Asn 
    210                 215                 220                 


Leu Arg Glu Ile Ser Asp Tyr Ala Leu Glu Gly Leu Gln Ser Leu Glu 
225                 230                 235                 240 


Ser Leu Ser Phe Tyr Asp Asn Gln Leu Ala Arg Val Pro Arg Arg Ala 
                245                 250                 255     


Leu Glu Gln Val Pro Gly Leu Lys Phe Leu Asp Leu Asn Lys Asn Pro 
            260                 265                 270         


Leu Gln Arg Val Gly Pro Gly Asp Phe Ala Asn Met Leu His Leu Lys 
        275                 280                 285             


Glu Leu Gly Leu Asn Asn Met Glu Glu Leu Val Ser Ile Asp Lys Phe 
    290                 295                 300                 


Ala Leu Val Asn Leu Pro Glu Leu Thr Lys Leu Asp Ile Thr Asn Asn 
305                 310                 315                 320 


Pro Arg Leu Ser Phe Ile His Pro Arg Ala Phe His His Leu Pro Gln 
                325                 330                 335     


Met Glu Thr Leu Met Leu Asn Asn Asn Ala Leu Ser Ala Leu His Gln 
            340                 345                 350         


Gln Thr Val Glu Ser Leu Pro Asn Leu Gln Glu Val Gly Leu His Gly 
        355                 360                 365             


Asn Pro Ile Arg Cys Asp Cys Val Ile Arg Trp Ala Asn Ala Thr Gly 
    370                 375                 380                 


Thr Arg Val Arg Phe Ile Glu Pro Gln Ser Thr Leu Cys Ala Glu Pro 
385                 390                 395                 400 


Pro Asp Leu Gln Arg Leu Pro Val Arg Glu Val Pro Phe Arg Glu Met 
                405                 410                 415     


Thr Asp His Cys Leu Pro Leu Ile Ser Pro Arg Ser Phe Pro Pro Ser 
            420                 425                 430         


Leu Gln Val Ala Ser Gly Glu Ser Met Val Leu His Cys Arg Ala Leu 
        435                 440                 445             


Ala Glu Pro Glu Pro Glu Ile Tyr Trp Val Thr Pro Ala Gly Leu Arg 
    450                 455                 460                 


Leu Thr Pro Ala His Ala Gly Arg Arg Tyr Arg Val Tyr Pro Glu Gly 
465                 470                 475                 480 


Thr Leu Glu Leu Arg Arg Val Thr Ala Glu Glu Ala Gly Leu Tyr Thr 
                485                 490                 495     


Cys Val Ala Gln Asn Leu Val Gly Ala Asp Thr Lys Thr Val Ser Val 
            500                 505                 510         


Val Val Gly Arg Ala Leu Leu Gln Pro Gly Arg Asp Glu Gly Gln Gly 
        515                 520                 525             


Leu Glu Leu Arg Val Gln Glu Thr His Pro Tyr His Ile Leu Leu Ser 
    530                 535                 540                 


Trp Val Thr Pro Pro Asn Thr Val Ser Thr Asn Leu Thr Trp Ser Ser 
545                 550                 555                 560 


Ala Ser Ser Leu Arg Gly Gln Gly Ala Thr Ala Leu Ala Arg Leu Pro 
                565                 570                 575     


Arg Gly Thr His Ser Tyr Asn Ile Thr Arg Leu Leu Gln Ala Thr Glu 
            580                 585                 590         


Tyr Trp Ala Cys Leu Gln Val Ala Phe Ala Asp Ala His Thr Gln Leu 
        595                 600                 605             


Ala Cys Val Trp Ala Arg Thr Lys Glu Ala Thr Ser Cys His Arg Ala 
    610                 615                 620                 


Leu Gly Asp Arg Pro Gly Leu Ile Ala Ile Leu Ala Leu Ala Val Leu 
625                 630                 635                 640 


Leu Leu Ala Ala Gly Leu Ala Ala His Leu Gly Thr Gly Gln Pro Arg 
                645                 650                 655     


Lys Gly Val Gly Gly Arg Arg Pro Leu Pro Pro Ala Trp Ala Phe Trp 
            660                 665                 670         


Gly Trp Ser Ala Pro Ser Val Arg Val Val Ser Ala Pro Leu Val Leu 
        675                 680                 685             


Pro Trp Asn Pro Gly Arg Lys Leu Pro Arg Ser Ser Glu Gly Glu Thr 
    690                 695                 700                 


Leu Leu Pro Pro Leu Ser Gln Asn Ser 
705                 710             

<210>  1360
<211>  3359
<212>  DNA
<213>  Homo sapiens

<400>  1360
gataattaga ttctctggtg attagggaca gtttccaaac gtggggagag gagatggaaa     60

tccaaccttg aagtggaaaa agaatgtacg gaattgaggc tcactgttgg gaggtgggaa    120

agagggctca cagactgaga gctaattggc tcaaggccga cacctcctgg caagccaacg    180

tttccagctc agatctgcct gtctggacta gtgggggaaa gcactgaaga cccacagatc    240

tacgtcgggg gcatccaggc tctttcccag gccagctgtg tgaccttgta cacctgtaat    300

ctccctgaag ccagggctgc ccctgatggg gcctggcaat gactgagcag gcccagcccc    360

agaggacaag gaagagaagg catattgagg agggcaagaa gtgacgcccg gtgtagaatg    420

actgccctgg gagggtggtt ccttgggccc tggcagggtt gctgaccctt accctgcaaa    480

acacaaagag caggactcca gactcttctt gtgaatggtc ccctgccctg cagctccacc    540

atgaggcttc tcgtggcccc actcttgcta gcttgggtgg ctggtgccac tgccgctgtg    600

cccgtggtac cctggcatgt tccctgcccc cctcagtgtg cctgccagat ccggccctgg    660

tatacgcccc gctcgtccta ccgcgaggct accactgtgg actgcaatga cctattcctg    720

acggcagtcc ccccggcact ccccgcaggc acacagaccc tgctcctgca gagcaacagc    780

attgtccgtg tggaccagag tgagctgggc tacctggcca atctcacaga gctggacctg    840

tcccagaaca gcttttcgga tgcccgagac tgtgatttcc atgccctgcc ccagctgctg    900

agcctgcacc tagaggagaa ccagctgacc cggctggagg accacagctt tgcagggctg    960

gccagcctac aggaactcta tctcaaccac aaccagctct accgcatcgc ccccagggcc   1020

ttttctggcc tcagcaactt gctgcggctg cacctcaact ccaacctcct gagggccatt   1080

gacagccgct ggtttgaaat gctgcccaac ttggagatac tcatgattgg cggcaacaag   1140

gtagatgcca tcctggacat gaacttccgg cccctggcca acctgcgtag cctggtgcta   1200

gcaggcatga acctgcggga gatctccgac tatgccctgg aggggctgca aagcctggag   1260

agcctctcct tctatgacaa ccagctggcc cgggtgccca ggcgggcact ggaacaggtg   1320

cccgggctca agttcctaga cctcaacaag aacccgctcc agcgggtagg gccgggggac   1380

tttgccaaca tgctgcacct taaggagctg ggactgaaca acatggagga gctggtctcc   1440

atcgacaagt ttgccctggt gaacctcccc gagctgacca agctggacat caccaataac   1500

ccacggctgt ccttcatcca cccccgcgcc ttccaccacc tgccccagat ggagaccctc   1560

atgctcaaca acaacgctct cagtgccttg caccagcaga cggtggagtc cctgcccaac   1620

ctgcaggagg taggtctcca cggcaacccc atccgctgtg actgtgtcat ccgctgggcc   1680

aatgccacgg gcacccgtgt ccgcttcatc gagccgcaat ccaccctgtg tgcggagcct   1740

ccggacctcc agcgcctccc ggtccgtgag gtgcccttcc gggagatgac ggaccactgt   1800

ttgcccctca tctccccacg aagcttcccc ccaagcctcc aggtagccag tggagagagc   1860

atggtgctgc attgccgggc actggccgaa cccgaacccg agatctactg ggtcactcca   1920

gctgggcttc gactgacacc tgcccatgca ggcaggaggt accgggtgta ccccgagggg   1980

accctggagc tgcggagggt gacagcagaa gaggcagggc tatacacctg tgtggcccag   2040

aacctggtgg gggctgacac taagacggtt agtgtggttg tgggccgtgc tctcctccag   2100

ccaggcaggg acgaaggaca ggggctggag ctccgggtgc aggagaccca cccctatcac   2160

atcctgctat cttgggtcac cccacccaac acagtgtcca ccaacctcac ctggtccagt   2220

gcctcctccc tccggggcca gggggccaca gctctggccc gcctgcctcg gggaacccac   2280

agctacaaca ttacccgcct ccttcaggcc acggagtact gggcctgcct gcaagtggcc   2340

tttgctgatg cccacaccca gttggcttgt gtatgggcca ggaccaaaga ggccacttct   2400

tgccacagag ccttagggga ccgtcctggg ctcattgcca tcctggctct cgctgtcctt   2460

ctcctggcag ctgggctagc ggcccacctt ggcacaggcc aacccaggaa gggtgtgggt   2520

gggaggcggc ctctccctcc agcctgggct ttctggggct ggagtgcccc ttctgtccgg   2580

gttgtgtctg ctcccctcgt cctgccctgg aatccaggga ggaagctgcc cagatcctca   2640

gaaggggaga cactgttgcc accattgtct caaaattctt gaagctcagc ctgttctcag   2700

cagtagagaa atcactagga ctacttttta ccaaaagaga agcagtctgg gccagatgcc   2760

ctgccaggaa agggacatgg acccacgtgc ttgaggcctg gcagctgggc caagacagat   2820

ggggctttgt ggccctgggg gtgcttctgc agcctcgaaa aagttgccct tacctcctag   2880

ggtcacctct gctgccattc tgaggaacat ctccaaggaa caggagggac tttggctaga   2940

gcctcctgcc tccccatctt ctctctgccc agaggctcct gggcctggct tggctgtccc   3000

ctacctgtgt ccccgggctg caccccttcc tcttctcttt ctctgtacag tctcagttgc   3060

ttgctcttgt gcctcctggg caagggctga aggaggccac tccatctcac ctcggggggc   3120

tgccctcaat gtgggagtga ccccagccag atctgaagga catttgggag agggatgccc   3180

aggaacgcct catctcagca gcctgggctc ggcattccga agctgacttt ctataggcaa   3240

ttttgtacct ttgtggagaa atgtgtcacc tcccccaacc cgattcactc ttttctcctg   3300

ttttgtaaaa aataaaaata aataataaca ataatacggg ggaaaggaac gaaaggaaa    3359


<210>  1361
<211>  713
<212>  PRT
<213>  Homo sapiens

<400>  1361


Met Arg Leu Leu Val Ala Pro Leu Leu Leu Ala Trp Val Ala Gly Ala 
1               5                   10                  15      


Thr Ala Ala Val Pro Val Val Pro Trp His Val Pro Cys Pro Pro Gln 
            20                  25                  30          


Cys Ala Cys Gln Ile Arg Pro Trp Tyr Thr Pro Arg Ser Ser Tyr Arg 
        35                  40                  45              


Glu Ala Thr Thr Val Asp Cys Asn Asp Leu Phe Leu Thr Ala Val Pro 
    50                  55                  60                  


Pro Ala Leu Pro Ala Gly Thr Gln Thr Leu Leu Leu Gln Ser Asn Ser 
65                  70                  75                  80  


Ile Val Arg Val Asp Gln Ser Glu Leu Gly Tyr Leu Ala Asn Leu Thr 
                85                  90                  95      


Glu Leu Asp Leu Ser Gln Asn Ser Phe Ser Asp Ala Arg Asp Cys Asp 
            100                 105                 110         


Phe His Ala Leu Pro Gln Leu Leu Ser Leu His Leu Glu Glu Asn Gln 
        115                 120                 125             


Leu Thr Arg Leu Glu Asp His Ser Phe Ala Gly Leu Ala Ser Leu Gln 
    130                 135                 140                 


Glu Leu Tyr Leu Asn His Asn Gln Leu Tyr Arg Ile Ala Pro Arg Ala 
145                 150                 155                 160 


Phe Ser Gly Leu Ser Asn Leu Leu Arg Leu His Leu Asn Ser Asn Leu 
                165                 170                 175     


Leu Arg Ala Ile Asp Ser Arg Trp Phe Glu Met Leu Pro Asn Leu Glu 
            180                 185                 190         


Ile Leu Met Ile Gly Gly Asn Lys Val Asp Ala Ile Leu Asp Met Asn 
        195                 200                 205             


Phe Arg Pro Leu Ala Asn Leu Arg Ser Leu Val Leu Ala Gly Met Asn 
    210                 215                 220                 


Leu Arg Glu Ile Ser Asp Tyr Ala Leu Glu Gly Leu Gln Ser Leu Glu 
225                 230                 235                 240 


Ser Leu Ser Phe Tyr Asp Asn Gln Leu Ala Arg Val Pro Arg Arg Ala 
                245                 250                 255     


Leu Glu Gln Val Pro Gly Leu Lys Phe Leu Asp Leu Asn Lys Asn Pro 
            260                 265                 270         


Leu Gln Arg Val Gly Pro Gly Asp Phe Ala Asn Met Leu His Leu Lys 
        275                 280                 285             


Glu Leu Gly Leu Asn Asn Met Glu Glu Leu Val Ser Ile Asp Lys Phe 
    290                 295                 300                 


Ala Leu Val Asn Leu Pro Glu Leu Thr Lys Leu Asp Ile Thr Asn Asn 
305                 310                 315                 320 


Pro Arg Leu Ser Phe Ile His Pro Arg Ala Phe His His Leu Pro Gln 
                325                 330                 335     


Met Glu Thr Leu Met Leu Asn Asn Asn Ala Leu Ser Ala Leu His Gln 
            340                 345                 350         


Gln Thr Val Glu Ser Leu Pro Asn Leu Gln Glu Val Gly Leu His Gly 
        355                 360                 365             


Asn Pro Ile Arg Cys Asp Cys Val Ile Arg Trp Ala Asn Ala Thr Gly 
    370                 375                 380                 


Thr Arg Val Arg Phe Ile Glu Pro Gln Ser Thr Leu Cys Ala Glu Pro 
385                 390                 395                 400 


Pro Asp Leu Gln Arg Leu Pro Val Arg Glu Val Pro Phe Arg Glu Met 
                405                 410                 415     


Thr Asp His Cys Leu Pro Leu Ile Ser Pro Arg Ser Phe Pro Pro Ser 
            420                 425                 430         


Leu Gln Val Ala Ser Gly Glu Ser Met Val Leu His Cys Arg Ala Leu 
        435                 440                 445             


Ala Glu Pro Glu Pro Glu Ile Tyr Trp Val Thr Pro Ala Gly Leu Arg 
    450                 455                 460                 


Leu Thr Pro Ala His Ala Gly Arg Arg Tyr Arg Val Tyr Pro Glu Gly 
465                 470                 475                 480 


Thr Leu Glu Leu Arg Arg Val Thr Ala Glu Glu Ala Gly Leu Tyr Thr 
                485                 490                 495     


Cys Val Ala Gln Asn Leu Val Gly Ala Asp Thr Lys Thr Val Ser Val 
            500                 505                 510         


Val Val Gly Arg Ala Leu Leu Gln Pro Gly Arg Asp Glu Gly Gln Gly 
        515                 520                 525             


Leu Glu Leu Arg Val Gln Glu Thr His Pro Tyr His Ile Leu Leu Ser 
    530                 535                 540                 


Trp Val Thr Pro Pro Asn Thr Val Ser Thr Asn Leu Thr Trp Ser Ser 
545                 550                 555                 560 


Ala Ser Ser Leu Arg Gly Gln Gly Ala Thr Ala Leu Ala Arg Leu Pro 
                565                 570                 575     


Arg Gly Thr His Ser Tyr Asn Ile Thr Arg Leu Leu Gln Ala Thr Glu 
            580                 585                 590         


Tyr Trp Ala Cys Leu Gln Val Ala Phe Ala Asp Ala His Thr Gln Leu 
        595                 600                 605             


Ala Cys Val Trp Ala Arg Thr Lys Glu Ala Thr Ser Cys His Arg Ala 
    610                 615                 620                 


Leu Gly Asp Arg Pro Gly Leu Ile Ala Ile Leu Ala Leu Ala Val Leu 
625                 630                 635                 640 


Leu Leu Ala Ala Gly Leu Ala Ala His Leu Gly Thr Gly Gln Pro Arg 
                645                 650                 655     


Lys Gly Val Gly Gly Arg Arg Pro Leu Pro Pro Ala Trp Ala Phe Trp 
            660                 665                 670         


Gly Trp Ser Ala Pro Ser Val Arg Val Val Ser Ala Pro Leu Val Leu 
        675                 680                 685             


Pro Trp Asn Pro Gly Arg Lys Leu Pro Arg Ser Ser Glu Gly Glu Thr 
    690                 695                 700                 


Leu Leu Pro Pro Leu Ser Gln Asn Ser 
705                 710             

<210>  1362
<211>  3154
<212>  DNA
<213>  Homo sapiens

<400>  1362
cagcagacgg cagacggtgc ccggcgccca cgggaagctg aagatacagc ggtaaacaaa     60

cctccatgtc tcaagctgac cacacttgta tctggacttg ccagctgatt agctctgttc    120

ccaccaggct cgttcaaaga cccacagctt gagggggcag agggctgccc ctgatggggc    180

ctggcaatga ctgagcaggc ccagccccag aggacaagga agagaaggca tattgaggag    240

ggcaagaagt gacgcccggt gtagaatgac tgccctggga gggtggttcc ttgggccctg    300

gcagggttgc tgacccttac cctgcaaaac acaaagagca ggactccaga ctcttcttgt    360

gaatggtccc ctgccctgca gctccaccat gaggcttctc gtggccccac tcttgctagc    420

ttgggtggct ggtgccactg ccgctgtgcc cgtggtaccc tggcatgttc cctgcccccc    480

tcagtgtgcc tgccagatcc ggccctggta tacgccccgc tcgtcctacc gcgaggctac    540

cactgtggac tgcaatgacc tattcctgac ggcagtcccc ccggcactcc ccgcaggcac    600

acagaccctg ctcctgcaga gcaacagcat tgtccgtgtg gaccagagtg agctgggcta    660

cctggccaat ctcacagagc tggacctgtc ccagaacagc ttttcggatg cccgagactg    720

tgatttccat gccctgcccc agctgctgag cctgcaccta gaggagaacc agctgacccg    780

gctggaggac cacagctttg cagggctggc cagcctacag gaactctatc tcaaccacaa    840

ccagctctac cgcatcgccc ccagggcctt ttctggcctc agcaacttgc tgcggctgca    900

cctcaactcc aacctcctga gggccattga cagccgctgg tttgaaatgc tgcccaactt    960

ggagatactc atgattggcg gcaacaaggt agatgccatc ctggacatga acttccggcc   1020

cctggccaac ctgcgtagcc tggtgctagc aggcatgaac ctgcgggaga tctccgacta   1080

tgccctggag gggctgcaaa gcctggagag cctctccttc tatgacaacc agctggcccg   1140

ggtgcccagg cgggcactgg aacaggtgcc cgggctcaag ttcctagacc tcaacaagaa   1200

cccgctccag cgggtagggc cgggggactt tgccaacatg ctgcacctta aggagctggg   1260

actgaacaac atggaggagc tggtctccat cgacaagttt gccctggtga acctccccga   1320

gctgaccaag ctggacatca ccaataaccc acggctgtcc ttcatccacc cccgcgcctt   1380

ccaccacctg ccccagatgg agaccctcat gctcaacaac aacgctctca gtgccttgca   1440

ccagcagacg gtggagtccc tgcccaacct gcaggaggta ggtctccacg gcaaccccat   1500

ccgctgtgac tgtgtcatcc gctgggccaa tgccacgggc acccgtgtcc gcttcatcga   1560

gccgcaatcc accctgtgtg cggagcctcc ggacctccag cgcctcccgg tccgtgaggt   1620

gcccttccgg gagatgacgg accactgttt gcccctcatc tccccacgaa gcttcccccc   1680

aagcctccag gtagccagtg gagagagcat ggtgctgcat tgccgggcac tggccgaacc   1740

cgaacccgag atctactggg tcactccagc tgggcttcga ctgacacctg cccatgcagg   1800

caggaggtac cgggtgtacc ccgaggggac cctggagctg cggagggtga cagcagaaga   1860

ggcagggcta tacacctgtg tggcccagaa cctggtgggg gctgacacta agacggttag   1920

tgtggttgtg ggccgtgctc tcctccagcc aggcagggac gaaggacagg ggctggagct   1980

ccgggtgcag gagacccacc cctatcacat cctgctatct tgggtcaccc cacccaacac   2040

agtgtccacc aacctcacct ggtccagtgc ctcctccctc cggggccagg gggccacagc   2100

tctggcccgc ctgcctcggg gaacccacag ctacaacatt acccgcctcc ttcaggccac   2160

ggagtactgg gcctgcctgc aagtggcctt tgctgatgcc cacacccagt tggcttgtgt   2220

atgggccagg accaaagagg ccacttcttg ccacagagcc ttaggggacc gtcctgggct   2280

cattgccatc ctggctctcg ctgtccttct cctggcagct gggctagcgg cccaccttgg   2340

cacaggccaa cccaggaagg gtgtgggtgg gaggcggcct ctccctccag cctgggcttt   2400

ctggggctgg agtgcccctt ctgtccgggt tgtgtctgct cccctcgtcc tgccctggaa   2460

tccagggagg aagctgccca gatcctcaga aggggagaca ctgttgccac cattgtctca   2520

aaattcttga agctcagcct gttctcagca gtagagaaat cactaggact actttttacc   2580

aaaagagaag cagtctgggc cagatgccct gccaggaaag ggacatggac ccacgtgctt   2640

gaggcctggc agctgggcca agacagatgg ggctttgtgg ccctgggggt gcttctgcag   2700

cctcgaaaaa gttgccctta cctcctaggg tcacctctgc tgccattctg aggaacatct   2760

ccaaggaaca ggagggactt tggctagagc ctcctgcctc cccatcttct ctctgcccag   2820

aggctcctgg gcctggcttg gctgtcccct acctgtgtcc ccgggctgca ccccttcctc   2880

ttctctttct ctgtacagtc tcagttgctt gctcttgtgc ctcctgggca agggctgaag   2940

gaggccactc catctcacct cggggggctg ccctcaatgt gggagtgacc ccagccagat   3000

ctgaaggaca tttgggagag ggatgcccag gaacgcctca tctcagcagc ctgggctcgg   3060

cattccgaag ctgactttct ataggcaatt ttgtaccttt gtggagaaat gtgtcacctc   3120

ccccaacccg attcactctt ttctcctgtt ttgt                               3154


<210>  1363
<211>  713
<212>  PRT
<213>  Homo sapiens

<400>  1363


Met Arg Leu Leu Val Ala Pro Leu Leu Leu Ala Trp Val Ala Gly Ala 
1               5                   10                  15      


Thr Ala Ala Val Pro Val Val Pro Trp His Val Pro Cys Pro Pro Gln 
            20                  25                  30          


Cys Ala Cys Gln Ile Arg Pro Trp Tyr Thr Pro Arg Ser Ser Tyr Arg 
        35                  40                  45              


Glu Ala Thr Thr Val Asp Cys Asn Asp Leu Phe Leu Thr Ala Val Pro 
    50                  55                  60                  


Pro Ala Leu Pro Ala Gly Thr Gln Thr Leu Leu Leu Gln Ser Asn Ser 
65                  70                  75                  80  


Ile Val Arg Val Asp Gln Ser Glu Leu Gly Tyr Leu Ala Asn Leu Thr 
                85                  90                  95      


Glu Leu Asp Leu Ser Gln Asn Ser Phe Ser Asp Ala Arg Asp Cys Asp 
            100                 105                 110         


Phe His Ala Leu Pro Gln Leu Leu Ser Leu His Leu Glu Glu Asn Gln 
        115                 120                 125             


Leu Thr Arg Leu Glu Asp His Ser Phe Ala Gly Leu Ala Ser Leu Gln 
    130                 135                 140                 


Glu Leu Tyr Leu Asn His Asn Gln Leu Tyr Arg Ile Ala Pro Arg Ala 
145                 150                 155                 160 


Phe Ser Gly Leu Ser Asn Leu Leu Arg Leu His Leu Asn Ser Asn Leu 
                165                 170                 175     


Leu Arg Ala Ile Asp Ser Arg Trp Phe Glu Met Leu Pro Asn Leu Glu 
            180                 185                 190         


Ile Leu Met Ile Gly Gly Asn Lys Val Asp Ala Ile Leu Asp Met Asn 
        195                 200                 205             


Phe Arg Pro Leu Ala Asn Leu Arg Ser Leu Val Leu Ala Gly Met Asn 
    210                 215                 220                 


Leu Arg Glu Ile Ser Asp Tyr Ala Leu Glu Gly Leu Gln Ser Leu Glu 
225                 230                 235                 240 


Ser Leu Ser Phe Tyr Asp Asn Gln Leu Ala Arg Val Pro Arg Arg Ala 
                245                 250                 255     


Leu Glu Gln Val Pro Gly Leu Lys Phe Leu Asp Leu Asn Lys Asn Pro 
            260                 265                 270         


Leu Gln Arg Val Gly Pro Gly Asp Phe Ala Asn Met Leu His Leu Lys 
        275                 280                 285             


Glu Leu Gly Leu Asn Asn Met Glu Glu Leu Val Ser Ile Asp Lys Phe 
    290                 295                 300                 


Ala Leu Val Asn Leu Pro Glu Leu Thr Lys Leu Asp Ile Thr Asn Asn 
305                 310                 315                 320 


Pro Arg Leu Ser Phe Ile His Pro Arg Ala Phe His His Leu Pro Gln 
                325                 330                 335     


Met Glu Thr Leu Met Leu Asn Asn Asn Ala Leu Ser Ala Leu His Gln 
            340                 345                 350         


Gln Thr Val Glu Ser Leu Pro Asn Leu Gln Glu Val Gly Leu His Gly 
        355                 360                 365             


Asn Pro Ile Arg Cys Asp Cys Val Ile Arg Trp Ala Asn Ala Thr Gly 
    370                 375                 380                 


Thr Arg Val Arg Phe Ile Glu Pro Gln Ser Thr Leu Cys Ala Glu Pro 
385                 390                 395                 400 


Pro Asp Leu Gln Arg Leu Pro Val Arg Glu Val Pro Phe Arg Glu Met 
                405                 410                 415     


Thr Asp His Cys Leu Pro Leu Ile Ser Pro Arg Ser Phe Pro Pro Ser 
            420                 425                 430         


Leu Gln Val Ala Ser Gly Glu Ser Met Val Leu His Cys Arg Ala Leu 
        435                 440                 445             


Ala Glu Pro Glu Pro Glu Ile Tyr Trp Val Thr Pro Ala Gly Leu Arg 
    450                 455                 460                 


Leu Thr Pro Ala His Ala Gly Arg Arg Tyr Arg Val Tyr Pro Glu Gly 
465                 470                 475                 480 


Thr Leu Glu Leu Arg Arg Val Thr Ala Glu Glu Ala Gly Leu Tyr Thr 
                485                 490                 495     


Cys Val Ala Gln Asn Leu Val Gly Ala Asp Thr Lys Thr Val Ser Val 
            500                 505                 510         


Val Val Gly Arg Ala Leu Leu Gln Pro Gly Arg Asp Glu Gly Gln Gly 
        515                 520                 525             


Leu Glu Leu Arg Val Gln Glu Thr His Pro Tyr His Ile Leu Leu Ser 
    530                 535                 540                 


Trp Val Thr Pro Pro Asn Thr Val Ser Thr Asn Leu Thr Trp Ser Ser 
545                 550                 555                 560 


Ala Ser Ser Leu Arg Gly Gln Gly Ala Thr Ala Leu Ala Arg Leu Pro 
                565                 570                 575     


Arg Gly Thr His Ser Tyr Asn Ile Thr Arg Leu Leu Gln Ala Thr Glu 
            580                 585                 590         


Tyr Trp Ala Cys Leu Gln Val Ala Phe Ala Asp Ala His Thr Gln Leu 
        595                 600                 605             


Ala Cys Val Trp Ala Arg Thr Lys Glu Ala Thr Ser Cys His Arg Ala 
    610                 615                 620                 


Leu Gly Asp Arg Pro Gly Leu Ile Ala Ile Leu Ala Leu Ala Val Leu 
625                 630                 635                 640 


Leu Leu Ala Ala Gly Leu Ala Ala His Leu Gly Thr Gly Gln Pro Arg 
                645                 650                 655     


Lys Gly Val Gly Gly Arg Arg Pro Leu Pro Pro Ala Trp Ala Phe Trp 
            660                 665                 670         


Gly Trp Ser Ala Pro Ser Val Arg Val Val Ser Ala Pro Leu Val Leu 
        675                 680                 685             


Pro Trp Asn Pro Gly Arg Lys Leu Pro Arg Ser Ser Glu Gly Glu Thr 
    690                 695                 700                 


Leu Leu Pro Pro Leu Ser Gln Asn Ser 
705                 710             

<210>  1364
<211>  3492
<212>  DNA
<213>  Homo sapiens

<400>  1364
gcgagtgagg agggcgagcg cgaagccggg aagaggggcg cgcgtggagg gggtgccggg     60

cgccgcgagg gcctgctccg ggcacctgcg aacgcgcggc gctctcaagg agcgcctggc    120

tctcgcccgc cagcctccgg ccgcgacgcg cccagggcgc ggagaggggg tggggacgga    180

ttgggattct gccatcgccc tcaccggctg ggccctggag ccgctcccag gataactcca    240

cgttggggag ggcgcccgcc gagcctcccc ggcctgtgca gacggcgcgc gcggcgggag    300

ggcgcggacc agcgtcccca gcccggcccc gggcggaagg cgagcggagc gcggccgcgc    360

gggcagcaga cggcagacgg tgcccggcgc ccacgggttc tggaggctgg gaagtccaag    420

acaaggtgcc agcatctggt gaaggctgct gtctgctttc aagatggtgc ctcgaatgct    480

gtttcctcac atggcagaag ggctgcccct gatggggcct ggcaatgact gagcaggccc    540

agccccagag gacaaggaag agaaggcata ttgaggaggg caagaagtga cgcccggtgt    600

agaatgactg ccctgggagg gtggttcctt gggccctggc agggttgctg acccttaccc    660

tgcaaaacac aaagagcagg actccagact cttcttgtga atggtcccct gccctgcagc    720

tccaccatga ggcttctcgt ggccccactc ttgctagctt gggtggctgg tgccactgcc    780

gctgtgcccg tggtaccctg gcatgttccc tgcccccctc agtgtgcctg ccagatccgg    840

ccctggtata cgccccgctc gtcctaccgc gaggctacca ctgtggactg caatgaccta    900

ttcctgacgg cagtcccccc ggcactcccc gcaggcacac agaccctgct cctgcagagc    960

aacagcattg tccgtgtgga ccagagtgag ctgggctacc tggccaatct cacagagctg   1020

gacctgtccc agaacagctt ttcggatgcc cgagactgtg atttccatgc cctgccccag   1080

ctgctgagcc tgcacctaga ggagaaccag ctgacccggc tggaggacca cagctttgca   1140

gggctggcca gcctacagga actctatctc aaccacaacc agctctaccg catcgccccc   1200

agggcctttt ctggcctcag caacttgctg cggctgcacc tcaactccaa cctcctgagg   1260

gccattgaca gccgctggtt tgaaatgctg cccaacttgg agatactcat gattggcggc   1320

aacaaggtag atgccatcct ggacatgaac ttccggcccc tggccaacct gcgtagcctg   1380

gtgctagcag gcatgaacct gcgggagatc tccgactatg ccctggaggg gctgcaaagc   1440

ctggagagcc tctccttcta tgacaaccag ctggcccggg tgcccaggcg ggcactggaa   1500

caggtgcccg ggctcaagtt cctagacctc aacaagaacc cgctccagcg ggtagggccg   1560

ggggactttg ccaacatgct gcaccttaag gagctgggac tgaacaacat ggaggagctg   1620

gtctccatcg acaagtttgc cctggtgaac ctccccgagc tgaccaagct ggacatcacc   1680

aataacccac ggctgtcctt catccacccc cgcgccttcc accacctgcc ccagatggag   1740

accctcatgc tcaacaacaa cgctctcagt gccttgcacc agcagacggt ggagtccctg   1800

cccaacctgc aggaggtagg tctccacggc aaccccatcc gctgtgactg tgtcatccgc   1860

tgggccaatg ccacgggcac ccgtgtccgc ttcatcgagc cgcaatccac cctgtgtgcg   1920

gagcctccgg acctccagcg cctcccggtc cgtgaggtgc ccttccggga gatgacggac   1980

cactgtttgc ccctcatctc cccacgaagc ttccccccaa gcctccaggt agccagtgga   2040

gagagcatgg tgctgcattg ccgggcactg gccgaacccg aacccgagat ctactgggtc   2100

actccagctg ggcttcgact gacacctgcc catgcaggca ggaggtaccg ggtgtacccc   2160

gaggggaccc tggagctgcg gagggtgaca gcagaagagg cagggctata cacctgtgtg   2220

gcccagaacc tggtgggggc tgacactaag acggttagtg tggttgtggg ccgtgctctc   2280

ctccagccag gcagggacga aggacagggg ctggagctcc gggtgcagga gacccacccc   2340

tatcacatcc tgctatcttg ggtcacccca cccaacacag tgtccaccaa cctcacctgg   2400

tccagtgcct cctccctccg gggccagggg gccacagctc tggcccgcct gcctcgggga   2460

acccacagct acaacattac ccgcctcctt caggccacgg agtactgggc ctgcctgcaa   2520

gtggcctttg ctgatgccca cacccagttg gcttgtgtat gggccaggac caaagaggcc   2580

acttcttgcc acagagcctt aggggaccgt cctgggctca ttgccatcct ggctctcgct   2640

gtccttctcc tggcagctgg gctagcggcc caccttggca caggccaacc caggaagggt   2700

gtgggtggga ggcggcctct ccctccagcc tgggctttct ggggctggag tgccccttct   2760

gtccgggttg tgtctgctcc cctcgtcctg ccctggaatc cagggaggaa gctgcccaga   2820

tcctcagaag gggagacact gttgccacca ttgtctcaaa attcttgaag ctcagcctgt   2880

tctcagcagt agagaaatca ctaggactac tttttaccaa aagagaagca gtctgggcca   2940

gatgccctgc caggaaaggg acatggaccc acgtgcttga ggcctggcag ctgggccaag   3000

acagatgggg ctttgtggcc ctgggggtgc ttctgcagcc tcgaaaaagt tgcccttacc   3060

tcctagggtc acctctgctg ccattctgag gaacatctcc aaggaacagg agggactttg   3120

gctagagcct cctgcctccc catcttctct ctgcccagag gctcctgggc ctggcttggc   3180

tgtcccctac ctgtgtcccc gggctgcacc ccttcctctt ctctttctct gtacagtctc   3240

agttgcttgc tcttgtgcct cctgggcaag ggctgaagga ggccactcca tctcacctcg   3300

gggggctgcc ctcaatgtgg gagtgacccc agccagatct gaaggacatt tgggagaggg   3360

atgcccagga acgcctcatc tcagcagcct gggctcggca ttccgaagct gactttctat   3420

aggcaatttt gtacctttgt ggagaaatgt gtcacctccc ccaacccgat tcactctttt   3480

ctcctgtttt gt                                                       3492


<210>  1365
<211>  713
<212>  PRT
<213>  Homo sapiens

<400>  1365


Met Arg Leu Leu Val Ala Pro Leu Leu Leu Ala Trp Val Ala Gly Ala 
1               5                   10                  15      


Thr Ala Ala Val Pro Val Val Pro Trp His Val Pro Cys Pro Pro Gln 
            20                  25                  30          


Cys Ala Cys Gln Ile Arg Pro Trp Tyr Thr Pro Arg Ser Ser Tyr Arg 
        35                  40                  45              


Glu Ala Thr Thr Val Asp Cys Asn Asp Leu Phe Leu Thr Ala Val Pro 
    50                  55                  60                  


Pro Ala Leu Pro Ala Gly Thr Gln Thr Leu Leu Leu Gln Ser Asn Ser 
65                  70                  75                  80  


Ile Val Arg Val Asp Gln Ser Glu Leu Gly Tyr Leu Ala Asn Leu Thr 
                85                  90                  95      


Glu Leu Asp Leu Ser Gln Asn Ser Phe Ser Asp Ala Arg Asp Cys Asp 
            100                 105                 110         


Phe His Ala Leu Pro Gln Leu Leu Ser Leu His Leu Glu Glu Asn Gln 
        115                 120                 125             


Leu Thr Arg Leu Glu Asp His Ser Phe Ala Gly Leu Ala Ser Leu Gln 
    130                 135                 140                 


Glu Leu Tyr Leu Asn His Asn Gln Leu Tyr Arg Ile Ala Pro Arg Ala 
145                 150                 155                 160 


Phe Ser Gly Leu Ser Asn Leu Leu Arg Leu His Leu Asn Ser Asn Leu 
                165                 170                 175     


Leu Arg Ala Ile Asp Ser Arg Trp Phe Glu Met Leu Pro Asn Leu Glu 
            180                 185                 190         


Ile Leu Met Ile Gly Gly Asn Lys Val Asp Ala Ile Leu Asp Met Asn 
        195                 200                 205             


Phe Arg Pro Leu Ala Asn Leu Arg Ser Leu Val Leu Ala Gly Met Asn 
    210                 215                 220                 


Leu Arg Glu Ile Ser Asp Tyr Ala Leu Glu Gly Leu Gln Ser Leu Glu 
225                 230                 235                 240 


Ser Leu Ser Phe Tyr Asp Asn Gln Leu Ala Arg Val Pro Arg Arg Ala 
                245                 250                 255     


Leu Glu Gln Val Pro Gly Leu Lys Phe Leu Asp Leu Asn Lys Asn Pro 
            260                 265                 270         


Leu Gln Arg Val Gly Pro Gly Asp Phe Ala Asn Met Leu His Leu Lys 
        275                 280                 285             


Glu Leu Gly Leu Asn Asn Met Glu Glu Leu Val Ser Ile Asp Lys Phe 
    290                 295                 300                 


Ala Leu Val Asn Leu Pro Glu Leu Thr Lys Leu Asp Ile Thr Asn Asn 
305                 310                 315                 320 


Pro Arg Leu Ser Phe Ile His Pro Arg Ala Phe His His Leu Pro Gln 
                325                 330                 335     


Met Glu Thr Leu Met Leu Asn Asn Asn Ala Leu Ser Ala Leu His Gln 
            340                 345                 350         


Gln Thr Val Glu Ser Leu Pro Asn Leu Gln Glu Val Gly Leu His Gly 
        355                 360                 365             


Asn Pro Ile Arg Cys Asp Cys Val Ile Arg Trp Ala Asn Ala Thr Gly 
    370                 375                 380                 


Thr Arg Val Arg Phe Ile Glu Pro Gln Ser Thr Leu Cys Ala Glu Pro 
385                 390                 395                 400 


Pro Asp Leu Gln Arg Leu Pro Val Arg Glu Val Pro Phe Arg Glu Met 
                405                 410                 415     


Thr Asp His Cys Leu Pro Leu Ile Ser Pro Arg Ser Phe Pro Pro Ser 
            420                 425                 430         


Leu Gln Val Ala Ser Gly Glu Ser Met Val Leu His Cys Arg Ala Leu 
        435                 440                 445             


Ala Glu Pro Glu Pro Glu Ile Tyr Trp Val Thr Pro Ala Gly Leu Arg 
    450                 455                 460                 


Leu Thr Pro Ala His Ala Gly Arg Arg Tyr Arg Val Tyr Pro Glu Gly 
465                 470                 475                 480 


Thr Leu Glu Leu Arg Arg Val Thr Ala Glu Glu Ala Gly Leu Tyr Thr 
                485                 490                 495     


Cys Val Ala Gln Asn Leu Val Gly Ala Asp Thr Lys Thr Val Ser Val 
            500                 505                 510         


Val Val Gly Arg Ala Leu Leu Gln Pro Gly Arg Asp Glu Gly Gln Gly 
        515                 520                 525             


Leu Glu Leu Arg Val Gln Glu Thr His Pro Tyr His Ile Leu Leu Ser 
    530                 535                 540                 


Trp Val Thr Pro Pro Asn Thr Val Ser Thr Asn Leu Thr Trp Ser Ser 
545                 550                 555                 560 


Ala Ser Ser Leu Arg Gly Gln Gly Ala Thr Ala Leu Ala Arg Leu Pro 
                565                 570                 575     


Arg Gly Thr His Ser Tyr Asn Ile Thr Arg Leu Leu Gln Ala Thr Glu 
            580                 585                 590         


Tyr Trp Ala Cys Leu Gln Val Ala Phe Ala Asp Ala His Thr Gln Leu 
        595                 600                 605             


Ala Cys Val Trp Ala Arg Thr Lys Glu Ala Thr Ser Cys His Arg Ala 
    610                 615                 620                 


Leu Gly Asp Arg Pro Gly Leu Ile Ala Ile Leu Ala Leu Ala Val Leu 
625                 630                 635                 640 


Leu Leu Ala Ala Gly Leu Ala Ala His Leu Gly Thr Gly Gln Pro Arg 
                645                 650                 655     


Lys Gly Val Gly Gly Arg Arg Pro Leu Pro Pro Ala Trp Ala Phe Trp 
            660                 665                 670         


Gly Trp Ser Ala Pro Ser Val Arg Val Val Ser Ala Pro Leu Val Leu 
        675                 680                 685             


Pro Trp Asn Pro Gly Arg Lys Leu Pro Arg Ser Ser Glu Gly Glu Thr 
    690                 695                 700                 


Leu Leu Pro Pro Leu Ser Gln Asn Ser 
705                 710             

<210>  1366
<211>  3389
<212>  DNA
<213>  Homo sapiens

<400>  1366
gcgagtgagg agggcgagcg cgaagccggg aagaggggcg cgcgtggagg gggtgccggg     60

cgccgcgagg gcctgctccg ggcacctgcg aacgcgcggc gctctcaagg agcgcctggc    120

tctcgcccgc cagcctccgg ccgcgacgcg cccagggcgc ggagaggggg tggggacgga    180

ttgggattct gccatcgccc tcaccggctg ggccctggag ccgctcccag gataactcca    240

cgttggggag ggcgcccgcc gagcctcccc ggcctgtgca gacggcgcgc gcggcgggag    300

ggcgcggacc agcgtcccca gcccggcccc gggcggaagg cgagcggagc gcggccgcgc    360

gggcagcaga cggcagacgg tgcccggcgc ccacgggggc tgcccctgat ggggcctggc    420

aatgactgag caggcccagc cccagaggac aaggaagaga aggcatattg aggagggcaa    480

gaagtgacgc ccggtgtaga atgactgccc tgggagggtg gttccttggg ccctggcagg    540

gttgctgacc cttaccctgc aaaacacaaa gagcaggact ccagactctt cttgtgaatg    600

gtcccctgcc ctgcagctcc accatgaggc ttctcgtggc cccactcttg ctagcttggg    660

tggctggtgc cactgccgct gtgcccgtgg taccctggca tgttccctgc ccccctcagt    720

gtgcctgcca gatccggccc tggtatacgc cccgctcgtc ctaccgcgag gctaccactg    780

tggactgcaa tgacctattc ctgacggcag tccccccggc actccccgca ggcacacaga    840

ccctgctcct gcagagcaac agcattgtcc gtgtggacca gagtgagctg ggctacctgg    900

ccaatctcac agagctggac ctgtcccaga acagcttttc ggatgcccga gactgtgatt    960

tccatgccct gccccagctg ctgagcctgc acctagagga gaaccagctg acccggctgg   1020

aggaccacag ctttgcaggg ctggccagcc tacaggaact ctatctcaac cacaaccagc   1080

tctaccgcat cgcccccagg gccttttctg gcctcagcaa cttgctgcgg ctgcacctca   1140

actccaacct cctgagggcc attgacagcc gctggtttga aatgctgccc aacttggaga   1200

tactcatgat tggcggcaac aaggtagatg ccatcctgga catgaacttc cggcccctgg   1260

ccaacctgcg tagcctggtg ctagcaggca tgaacctgcg ggagatctcc gactatgccc   1320

tggaggggct gcaaagcctg gagagcctct ccttctatga caaccagctg gcccgggtgc   1380

ccaggcgggc actggaacag gtgcccgggc tcaagttcct agacctcaac aagaacccgc   1440

tccagcgggt agggccgggg gactttgcca acatgctgca ccttaaggag ctgggactga   1500

acaacatgga ggagctggtc tccatcgaca agtttgccct ggtgaacctc cccgagctga   1560

ccaagctgga catcaccaat aacccacggc tgtccttcat ccacccccgc gccttccacc   1620

acctgcccca gatggagacc ctcatgctca acaacaacgc tctcagtgcc ttgcaccagc   1680

agacggtgga gtccctgccc aacctgcagg aggtaggtct ccacggcaac cccatccgct   1740

gtgactgtgt catccgctgg gccaatgcca cgggcacccg tgtccgcttc atcgagccgc   1800

aatccaccct gtgtgcggag cctccggacc tccagcgcct cccggtccgt gaggtgccct   1860

tccgggagat gacggaccac tgtttgcccc tcatctcccc acgaagcttc cccccaagcc   1920

tccaggtagc cagtggagag agcatggtgc tgcattgccg ggcactggcc gaacccgaac   1980

ccgagatcta ctgggtcact ccagctgggc ttcgactgac acctgcccat gcaggcagga   2040

ggtaccgggt gtaccccgag gggaccctgg agctgcggag ggtgacagca gaagaggcag   2100

ggctatacac ctgtgtggcc cagaacctgg tgggggctga cactaagacg gttagtgtgg   2160

ttgtgggccg tgctctcctc cagccaggca gggacgaagg acaggggctg gagctccggg   2220

tgcaggagac ccacccctat cacatcctgc tatcttgggt caccccaccc aacacagtgt   2280

ccaccaacct cacctggtcc agtgcctcct ccctccgggg ccagggggcc acagctctgg   2340

cccgcctgcc tcggggaacc cacagctaca acattacccg cctccttcag gccacggagt   2400

actgggcctg cctgcaagtg gcctttgctg atgcccacac ccagttggct tgtgtatggg   2460

ccaggaccaa agaggccact tcttgccaca gagccttagg ggaccgtcct gggctcattg   2520

ccatcctggc tctcgctgtc cttctcctgg cagctgggct agcggcccac cttggcacag   2580

gccaacccag gaagggtgtg ggtgggaggc ggcctctccc tccagcctgg gctttctggg   2640

gctggagtgc cccttctgtc cgggttgtgt ctgctcccct cgtcctgccc tggaatccag   2700

ggaggaagct gcccagatcc tcagaagggg agacactgtt gccaccattg tctcaaaatt   2760

cttgaagctc agcctgttct cagcagtaga gaaatcacta ggactacttt ttaccaaaag   2820

agaagcagtc tgggccagat gccctgccag gaaagggaca tggacccacg tgcttgaggc   2880

ctggcagctg ggccaagaca gatggggctt tgtggccctg ggggtgcttc tgcagcctcg   2940

aaaaagttgc ccttacctcc tagggtcacc tctgctgcca ttctgaggaa catctccaag   3000

gaacaggagg gactttggct agagcctcct gcctccccat cttctctctg cccagaggct   3060

cctgggcctg gcttggctgt cccctacctg tgtccccggg ctgcacccct tcctcttctc   3120

tttctctgta cagtctcagt tgcttgctct tgtgcctcct gggcaagggc tgaaggaggc   3180

cactccatct cacctcgggg ggctgccctc aatgtgggag tgaccccagc cagatctgaa   3240

ggacatttgg gagagggatg cccaggaacg cctcatctca gcagcctggg ctcggcattc   3300

cgaagctgac tttctatagg caattttgta cctttgtgga gaaatgtgtc acctccccca   3360

acccgattca ctcttttctc ctgttttgt                                     3389


<210>  1367
<211>  713
<212>  PRT
<213>  Homo sapiens

<400>  1367


Met Arg Leu Leu Val Ala Pro Leu Leu Leu Ala Trp Val Ala Gly Ala 
1               5                   10                  15      


Thr Ala Ala Val Pro Val Val Pro Trp His Val Pro Cys Pro Pro Gln 
            20                  25                  30          


Cys Ala Cys Gln Ile Arg Pro Trp Tyr Thr Pro Arg Ser Ser Tyr Arg 
        35                  40                  45              


Glu Ala Thr Thr Val Asp Cys Asn Asp Leu Phe Leu Thr Ala Val Pro 
    50                  55                  60                  


Pro Ala Leu Pro Ala Gly Thr Gln Thr Leu Leu Leu Gln Ser Asn Ser 
65                  70                  75                  80  


Ile Val Arg Val Asp Gln Ser Glu Leu Gly Tyr Leu Ala Asn Leu Thr 
                85                  90                  95      


Glu Leu Asp Leu Ser Gln Asn Ser Phe Ser Asp Ala Arg Asp Cys Asp 
            100                 105                 110         


Phe His Ala Leu Pro Gln Leu Leu Ser Leu His Leu Glu Glu Asn Gln 
        115                 120                 125             


Leu Thr Arg Leu Glu Asp His Ser Phe Ala Gly Leu Ala Ser Leu Gln 
    130                 135                 140                 


Glu Leu Tyr Leu Asn His Asn Gln Leu Tyr Arg Ile Ala Pro Arg Ala 
145                 150                 155                 160 


Phe Ser Gly Leu Ser Asn Leu Leu Arg Leu His Leu Asn Ser Asn Leu 
                165                 170                 175     


Leu Arg Ala Ile Asp Ser Arg Trp Phe Glu Met Leu Pro Asn Leu Glu 
            180                 185                 190         


Ile Leu Met Ile Gly Gly Asn Lys Val Asp Ala Ile Leu Asp Met Asn 
        195                 200                 205             


Phe Arg Pro Leu Ala Asn Leu Arg Ser Leu Val Leu Ala Gly Met Asn 
    210                 215                 220                 


Leu Arg Glu Ile Ser Asp Tyr Ala Leu Glu Gly Leu Gln Ser Leu Glu 
225                 230                 235                 240 


Ser Leu Ser Phe Tyr Asp Asn Gln Leu Ala Arg Val Pro Arg Arg Ala 
                245                 250                 255     


Leu Glu Gln Val Pro Gly Leu Lys Phe Leu Asp Leu Asn Lys Asn Pro 
            260                 265                 270         


Leu Gln Arg Val Gly Pro Gly Asp Phe Ala Asn Met Leu His Leu Lys 
        275                 280                 285             


Glu Leu Gly Leu Asn Asn Met Glu Glu Leu Val Ser Ile Asp Lys Phe 
    290                 295                 300                 


Ala Leu Val Asn Leu Pro Glu Leu Thr Lys Leu Asp Ile Thr Asn Asn 
305                 310                 315                 320 


Pro Arg Leu Ser Phe Ile His Pro Arg Ala Phe His His Leu Pro Gln 
                325                 330                 335     


Met Glu Thr Leu Met Leu Asn Asn Asn Ala Leu Ser Ala Leu His Gln 
            340                 345                 350         


Gln Thr Val Glu Ser Leu Pro Asn Leu Gln Glu Val Gly Leu His Gly 
        355                 360                 365             


Asn Pro Ile Arg Cys Asp Cys Val Ile Arg Trp Ala Asn Ala Thr Gly 
    370                 375                 380                 


Thr Arg Val Arg Phe Ile Glu Pro Gln Ser Thr Leu Cys Ala Glu Pro 
385                 390                 395                 400 


Pro Asp Leu Gln Arg Leu Pro Val Arg Glu Val Pro Phe Arg Glu Met 
                405                 410                 415     


Thr Asp His Cys Leu Pro Leu Ile Ser Pro Arg Ser Phe Pro Pro Ser 
            420                 425                 430         


Leu Gln Val Ala Ser Gly Glu Ser Met Val Leu His Cys Arg Ala Leu 
        435                 440                 445             


Ala Glu Pro Glu Pro Glu Ile Tyr Trp Val Thr Pro Ala Gly Leu Arg 
    450                 455                 460                 


Leu Thr Pro Ala His Ala Gly Arg Arg Tyr Arg Val Tyr Pro Glu Gly 
465                 470                 475                 480 


Thr Leu Glu Leu Arg Arg Val Thr Ala Glu Glu Ala Gly Leu Tyr Thr 
                485                 490                 495     


Cys Val Ala Gln Asn Leu Val Gly Ala Asp Thr Lys Thr Val Ser Val 
            500                 505                 510         


Val Val Gly Arg Ala Leu Leu Gln Pro Gly Arg Asp Glu Gly Gln Gly 
        515                 520                 525             


Leu Glu Leu Arg Val Gln Glu Thr His Pro Tyr His Ile Leu Leu Ser 
    530                 535                 540                 


Trp Val Thr Pro Pro Asn Thr Val Ser Thr Asn Leu Thr Trp Ser Ser 
545                 550                 555                 560 


Ala Ser Ser Leu Arg Gly Gln Gly Ala Thr Ala Leu Ala Arg Leu Pro 
                565                 570                 575     


Arg Gly Thr His Ser Tyr Asn Ile Thr Arg Leu Leu Gln Ala Thr Glu 
            580                 585                 590         


Tyr Trp Ala Cys Leu Gln Val Ala Phe Ala Asp Ala His Thr Gln Leu 
        595                 600                 605             


Ala Cys Val Trp Ala Arg Thr Lys Glu Ala Thr Ser Cys His Arg Ala 
    610                 615                 620                 


Leu Gly Asp Arg Pro Gly Leu Ile Ala Ile Leu Ala Leu Ala Val Leu 
625                 630                 635                 640 


Leu Leu Ala Ala Gly Leu Ala Ala His Leu Gly Thr Gly Gln Pro Arg 
                645                 650                 655     


Lys Gly Val Gly Gly Arg Arg Pro Leu Pro Pro Ala Trp Ala Phe Trp 
            660                 665                 670         


Gly Trp Ser Ala Pro Ser Val Arg Val Val Ser Ala Pro Leu Val Leu 
        675                 680                 685             


Pro Trp Asn Pro Gly Arg Lys Leu Pro Arg Ser Ser Glu Gly Glu Thr 
    690                 695                 700                 


Leu Leu Pro Pro Leu Ser Gln Asn Ser 
705                 710             

<210>  1368
<211>  3492
<212>  DNA
<213>  Homo sapiens

<400>  1368
gcgagtgagg agggcgagcg cgaagccggg aagaggggcg cgcgtggagg gggtgccggg     60

cgccgcgagg gcctgctccg ggcacctgcg aacgcgcggc gctctcaagg agcgcctggc    120

tctcgcccgc cagcctccgg ccgcgacgcg cccagggcgc ggagaggggg tggggacgga    180

ttgggattct gccatcgccc tcaccggctg ggccctggag ccgctcccag gataactcca    240

cgttggggag ggcgcccgcc gagcctcccc ggcctgtgca gacggcgcgc gcggcgggag    300

ggcgcggacc agcgtcccca gcccggcccc gggcggaagg cgagcggagc gcggccgcgc    360

gggcagcaga cggcagacgg tgcccggcgc ccacgggggg tgatgtctaa tctcctgaag    420

aaaggaactc tggagtcaca gagattgatt catacaatca acacacactg ggcacccatc    480

ccgtactaca ggcacaagag ggctgcccct gatggggcct ggcaatgact gagcaggccc    540

agccccagag gacaaggaag agaaggcata ttgaggaggg caagaagtga cgcccggtgt    600

agaatgactg ccctgggagg gtggttcctt gggccctggc agggttgctg acccttaccc    660

tgcaaaacac aaagagcagg actccagact cttcttgtga atggtcccct gccctgcagc    720

tccaccatga ggcttctcgt ggccccactc ttgctagctt gggtggctgg tgccactgcc    780

gctgtgcccg tggtaccctg gcatgttccc tgcccccctc agtgtgcctg ccagatccgg    840

ccctggtata cgccccgctc gtcctaccgc gaggctacca ctgtggactg caatgaccta    900

ttcctgacgg cagtcccccc ggcactcccc gcaggcacac agaccctgct cctgcagagc    960

aacagcattg tccgtgtgga ccagagtgag ctgggctacc tggccaatct cacagagctg   1020

gacctgtccc agaacagctt ttcggatgcc cgagactgtg atttccatgc cctgccccag   1080

ctgctgagcc tgcacctaga ggagaaccag ctgacccggc tggaggacca cagctttgca   1140

gggctggcca gcctacagga actctatctc aaccacaacc agctctaccg catcgccccc   1200

agggcctttt ctggcctcag caacttgctg cggctgcacc tcaactccaa cctcctgagg   1260

gccattgaca gccgctggtt tgaaatgctg cccaacttgg agatactcat gattggcggc   1320

aacaaggtag atgccatcct ggacatgaac ttccggcccc tggccaacct gcgtagcctg   1380

gtgctagcag gcatgaacct gcgggagatc tccgactatg ccctggaggg gctgcaaagc   1440

ctggagagcc tctccttcta tgacaaccag ctggcccggg tgcccaggcg ggcactggaa   1500

caggtgcccg ggctcaagtt cctagacctc aacaagaacc cgctccagcg ggtagggccg   1560

ggggactttg ccaacatgct gcaccttaag gagctgggac tgaacaacat ggaggagctg   1620

gtctccatcg acaagtttgc cctggtgaac ctccccgagc tgaccaagct ggacatcacc   1680

aataacccac ggctgtcctt catccacccc cgcgccttcc accacctgcc ccagatggag   1740

accctcatgc tcaacaacaa cgctctcagt gccttgcacc agcagacggt ggagtccctg   1800

cccaacctgc aggaggtagg tctccacggc aaccccatcc gctgtgactg tgtcatccgc   1860

tgggccaatg ccacgggcac ccgtgtccgc ttcatcgagc cgcaatccac cctgtgtgcg   1920

gagcctccgg acctccagcg cctcccggtc cgtgaggtgc ccttccggga gatgacggac   1980

cactgtttgc ccctcatctc cccacgaagc ttccccccaa gcctccaggt agccagtgga   2040

gagagcatgg tgctgcattg ccgggcactg gccgaacccg aacccgagat ctactgggtc   2100

actccagctg ggcttcgact gacacctgcc catgcaggca ggaggtaccg ggtgtacccc   2160

gaggggaccc tggagctgcg gagggtgaca gcagaagagg cagggctata cacctgtgtg   2220

gcccagaacc tggtgggggc tgacactaag acggttagtg tggttgtggg ccgtgctctc   2280

ctccagccag gcagggacga aggacagggg ctggagctcc gggtgcagga gacccacccc   2340

tatcacatcc tgctatcttg ggtcacccca cccaacacag tgtccaccaa cctcacctgg   2400

tccagtgcct cctccctccg gggccagggg gccacagctc tggcccgcct gcctcgggga   2460

acccacagct acaacattac ccgcctcctt caggccacgg agtactgggc ctgcctgcaa   2520

gtggcctttg ctgatgccca cacccagttg gcttgtgtat gggccaggac caaagaggcc   2580

acttcttgcc acagagcctt aggggaccgt cctgggctca ttgccatcct ggctctcgct   2640

gtccttctcc tggcagctgg gctagcggcc caccttggca caggccaacc caggaagggt   2700

gtgggtggga ggcggcctct ccctccagcc tgggctttct ggggctggag tgccccttct   2760

gtccgggttg tgtctgctcc cctcgtcctg ccctggaatc cagggaggaa gctgcccaga   2820

tcctcagaag gggagacact gttgccacca ttgtctcaaa attcttgaag ctcagcctgt   2880

tctcagcagt agagaaatca ctaggactac tttttaccaa aagagaagca gtctgggcca   2940

gatgccctgc caggaaaggg acatggaccc acgtgcttga ggcctggcag ctgggccaag   3000

acagatgggg ctttgtggcc ctgggggtgc ttctgcagcc tcgaaaaagt tgcccttacc   3060

tcctagggtc acctctgctg ccattctgag gaacatctcc aaggaacagg agggactttg   3120

gctagagcct cctgcctccc catcttctct ctgcccagag gctcctgggc ctggcttggc   3180

tgtcccctac ctgtgtcccc gggctgcacc ccttcctctt ctctttctct gtacagtctc   3240

agttgcttgc tcttgtgcct cctgggcaag ggctgaagga ggccactcca tctcacctcg   3300

gggggctgcc ctcaatgtgg gagtgacccc agccagatct gaaggacatt tgggagaggg   3360

atgcccagga acgcctcatc tcagcagcct gggctcggca ttccgaagct gactttctat   3420

aggcaatttt gtacctttgt ggagaaatgt gtcacctccc ccaacccgat tcactctttt   3480

ctcctgtttt gt                                                       3492


<210>  1369
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  1369


Met Ser Asn Leu Leu Lys Lys Gly Thr Leu Glu Ser Gln Arg Leu Ile 
1               5                   10                  15      


His Thr Ile Asn Thr His Trp Ala Pro Ile Pro Tyr Tyr Arg His Lys 
            20                  25                  30          


Arg Ala Ala Pro Asp Gly Ala Trp Gln 
        35                  40      

<210>  1370
<211>  3306
<212>  DNA
<213>  Homo sapiens

<400>  1370
gataattaga ttctctggtg attagggaca gtttccaaac gtggggagag gagatggaaa     60

tccaaccttg aagtggaaaa agaatgtacg gaattgaggc tcactgttgg gaggtgggaa    120

agagggctca cagactgaga gctaattggc tcaaggccga cacctcctgg caagccaacg    180

tttccagctc agatctgcct gtctggacta gtgggggaaa gcactgaaga cccacagatc    240

tacgtcgggg gcatccaggc tctttcccag gccagctgtg tgaccttgta cacctgtaat    300

ctccctgaag ccagggctgc ccctgatggg gcctggcaat gactgagcag gcccagcccc    360

agaggacaag gaagagaagg catattgagg agggcaagaa gtgacgcccg gtgtagaatg    420

actgccctgg gagggtggtt ccttgggccc tggcagggtt gctgaccctt accctgcaaa    480

acacaaagag caggactcca gactcttctt gtgaatggtc ccctgccctg cagctccacc    540

atgaggcttc tcgtggcccc actcttgcta gcttgggtgg ctggtgccac tgccgctgtg    600

cccgtggtac cctggcatgt tccctgcccc cctcagtgtg cctgccagat ccggccctgg    660

tatacgcccc gctcgtccta ccgcgaggct accactgtgg actgcaatga cctattcctg    720

acggcagtcc ccccggcact ccccgcaggc acacagaccc tgctcctgca gagcaacagc    780

attgtccgtg tggaccagag tgagctgggc tacctggcca atctcacaga gctggacctg    840

tcccagaaca gcttttcgga tgcccgagac tgtgatttcc atgccctgcc ccagctgctg    900

agcctgcacc tagaggagaa ccagctgacc cggctggagg accacagctt tgcagggctg    960

gccagcctac aggaactcta tctcaaccac aaccagctct accgcatcgc ccccagggcc   1020

ttttctggcc tcagcaactt gctgcggctg cacctcaact ccaacctcct gagggccatt   1080

gacagccgct ggtttgaaat gctgcccaac ttggagatac tcatgattgg cggcaacaag   1140

gtagatgcca tcctggacat gaacttccgg cccctggcca acctgcgtag cctggtgcta   1200

gcaggcatga acctgcggga gatctccgac tatgccctgg aggggctgca aagcctggag   1260

agcctctcct tctatgacaa ccagctggcc cgggtgccca ggcgggcact ggaacaggtg   1320

cccgggctca agttcctaga cctcaacaag aacccgctcc agcgggtagg gccgggggac   1380

tttgccaaca tgctgcacct taaggagctg ggactgaaca acatggagga gctggtctcc   1440

atcgacaagt ttgccctggt gaacctcccc gagctgacca agctggacat caccaataac   1500

ccacggctgt ccttcatcca cccccgcgcc ttccaccacc tgccccagat ggagaccctc   1560

atgctcaaca acaacgctct cagtgccttg caccagcaga cggtggagtc cctgcccaac   1620

ctgcaggagg taggtctcca cggcaacccc atccgctgtg actgtgtcat ccgctgggcc   1680

aatgccacgg gcacccgtgt ccgcttcatc gagccgcaat ccaccctgtg tgcggagcct   1740

ccggacctcc agcgcctccc ggtccgtgag gtgcccttcc gggagatgac ggaccactgt   1800

ttgcccctca tctccccacg aagcttcccc ccaagcctcc aggtagccag tggagagagc   1860

atggtgctgc attgccgggc actggccgaa cccgaacccg agatctactg ggtcactcca   1920

gctgggcttc gactgacacc tgcccatgca ggcaggaggt accgggtgta ccccgagggg   1980

accctggagc tgcggagggt gacagcagaa gaggcagggc tatacacctg tgtggcccag   2040

aacctggtgg gggctgacac taagacggtt agtgtggttg tgggccgtgc tctcctccag   2100

ccaggcaggg acgaaggaca ggggctggag ctccgggtgc aggagaccca cccctatcac   2160

atcctgctat cttgggtcac cccacccaac acagtgtcca ccaacctcac ctggtccagt   2220

gcctcctccc tccggggcca gggggccaca gctctggccc gcctgcctcg gggaacccac   2280

agctacaaca ttacccgcct ccttcaggcc acggagtact gggcctgcct gcaagtggcc   2340

tttgctgatg cccacaccca gttggcttgt gtatgggcca ggaccaaaga ggccacttct   2400

tgccacagag ccttagggga ccgtcctggg ctcattgcca tcctggctct cgctgtcctt   2460

ctcctggcag ctgggctagc ggcccacctt ggcacaggcc aacccaggaa gggtgtgggt   2520

gggaggcggc ctctccctcc agcctgggct ttctggggct ggagtgcccc ttctgtccgg   2580

gttgtgtctg ctcccctcgt cctgccctgg aatccaggga ggaagctgcc cagatcctca   2640

gaaggggaga cactgttgcc accattgtct caaaattctt gaagctcagc ctgttctcag   2700

cagtagagaa atcactagga ctacttttta ccaaaagaga agcagtctgg gccagatgcc   2760

ctgccaggaa agggacatgg acccacgtgc ttgaggcctg gcagctgggc caagacagat   2820

ggggctttgt ggccctgggg gtgcttctgc agcctcgaaa aagttgccct tacctcctag   2880

ggtcacctct gctgccattc tgaggaacat ctccaaggaa caggagggac tttggctaga   2940

gcctcctgcc tccccatctt ctctctgccc agaggctcct gggcctggct tggctgtccc   3000

ctacctgtgt ccccgggctg caccccttcc tcttctcttt ctctgtacag tctcagttgc   3060

ttgctcttgt gcctcctggg caagggctga aggaggccac tccatctcac ctcggggggc   3120

tgccctcaat gtgggagtga ccccagccag atctgaagga catttgggag agggatgccc   3180

aggaacgcct catctcagca gcctgggctc ggcattccga agctgacttt ctataggcaa   3240

ttttgtacct ttgtggagaa atgtgtcacc tcccccaacc cgattcactc ttttctcctg   3300

ttttgt                                                              3306


<210>  1371
<211>  713
<212>  PRT
<213>  Homo sapiens

<400>  1371


Met Arg Leu Leu Val Ala Pro Leu Leu Leu Ala Trp Val Ala Gly Ala 
1               5                   10                  15      


Thr Ala Ala Val Pro Val Val Pro Trp His Val Pro Cys Pro Pro Gln 
            20                  25                  30          


Cys Ala Cys Gln Ile Arg Pro Trp Tyr Thr Pro Arg Ser Ser Tyr Arg 
        35                  40                  45              


Glu Ala Thr Thr Val Asp Cys Asn Asp Leu Phe Leu Thr Ala Val Pro 
    50                  55                  60                  


Pro Ala Leu Pro Ala Gly Thr Gln Thr Leu Leu Leu Gln Ser Asn Ser 
65                  70                  75                  80  


Ile Val Arg Val Asp Gln Ser Glu Leu Gly Tyr Leu Ala Asn Leu Thr 
                85                  90                  95      


Glu Leu Asp Leu Ser Gln Asn Ser Phe Ser Asp Ala Arg Asp Cys Asp 
            100                 105                 110         


Phe His Ala Leu Pro Gln Leu Leu Ser Leu His Leu Glu Glu Asn Gln 
        115                 120                 125             


Leu Thr Arg Leu Glu Asp His Ser Phe Ala Gly Leu Ala Ser Leu Gln 
    130                 135                 140                 


Glu Leu Tyr Leu Asn His Asn Gln Leu Tyr Arg Ile Ala Pro Arg Ala 
145                 150                 155                 160 


Phe Ser Gly Leu Ser Asn Leu Leu Arg Leu His Leu Asn Ser Asn Leu 
                165                 170                 175     


Leu Arg Ala Ile Asp Ser Arg Trp Phe Glu Met Leu Pro Asn Leu Glu 
            180                 185                 190         


Ile Leu Met Ile Gly Gly Asn Lys Val Asp Ala Ile Leu Asp Met Asn 
        195                 200                 205             


Phe Arg Pro Leu Ala Asn Leu Arg Ser Leu Val Leu Ala Gly Met Asn 
    210                 215                 220                 


Leu Arg Glu Ile Ser Asp Tyr Ala Leu Glu Gly Leu Gln Ser Leu Glu 
225                 230                 235                 240 


Ser Leu Ser Phe Tyr Asp Asn Gln Leu Ala Arg Val Pro Arg Arg Ala 
                245                 250                 255     


Leu Glu Gln Val Pro Gly Leu Lys Phe Leu Asp Leu Asn Lys Asn Pro 
            260                 265                 270         


Leu Gln Arg Val Gly Pro Gly Asp Phe Ala Asn Met Leu His Leu Lys 
        275                 280                 285             


Glu Leu Gly Leu Asn Asn Met Glu Glu Leu Val Ser Ile Asp Lys Phe 
    290                 295                 300                 


Ala Leu Val Asn Leu Pro Glu Leu Thr Lys Leu Asp Ile Thr Asn Asn 
305                 310                 315                 320 


Pro Arg Leu Ser Phe Ile His Pro Arg Ala Phe His His Leu Pro Gln 
                325                 330                 335     


Met Glu Thr Leu Met Leu Asn Asn Asn Ala Leu Ser Ala Leu His Gln 
            340                 345                 350         


Gln Thr Val Glu Ser Leu Pro Asn Leu Gln Glu Val Gly Leu His Gly 
        355                 360                 365             


Asn Pro Ile Arg Cys Asp Cys Val Ile Arg Trp Ala Asn Ala Thr Gly 
    370                 375                 380                 


Thr Arg Val Arg Phe Ile Glu Pro Gln Ser Thr Leu Cys Ala Glu Pro 
385                 390                 395                 400 


Pro Asp Leu Gln Arg Leu Pro Val Arg Glu Val Pro Phe Arg Glu Met 
                405                 410                 415     


Thr Asp His Cys Leu Pro Leu Ile Ser Pro Arg Ser Phe Pro Pro Ser 
            420                 425                 430         


Leu Gln Val Ala Ser Gly Glu Ser Met Val Leu His Cys Arg Ala Leu 
        435                 440                 445             


Ala Glu Pro Glu Pro Glu Ile Tyr Trp Val Thr Pro Ala Gly Leu Arg 
    450                 455                 460                 


Leu Thr Pro Ala His Ala Gly Arg Arg Tyr Arg Val Tyr Pro Glu Gly 
465                 470                 475                 480 


Thr Leu Glu Leu Arg Arg Val Thr Ala Glu Glu Ala Gly Leu Tyr Thr 
                485                 490                 495     


Cys Val Ala Gln Asn Leu Val Gly Ala Asp Thr Lys Thr Val Ser Val 
            500                 505                 510         


Val Val Gly Arg Ala Leu Leu Gln Pro Gly Arg Asp Glu Gly Gln Gly 
        515                 520                 525             


Leu Glu Leu Arg Val Gln Glu Thr His Pro Tyr His Ile Leu Leu Ser 
    530                 535                 540                 


Trp Val Thr Pro Pro Asn Thr Val Ser Thr Asn Leu Thr Trp Ser Ser 
545                 550                 555                 560 


Ala Ser Ser Leu Arg Gly Gln Gly Ala Thr Ala Leu Ala Arg Leu Pro 
                565                 570                 575     


Arg Gly Thr His Ser Tyr Asn Ile Thr Arg Leu Leu Gln Ala Thr Glu 
            580                 585                 590         


Tyr Trp Ala Cys Leu Gln Val Ala Phe Ala Asp Ala His Thr Gln Leu 
        595                 600                 605             


Ala Cys Val Trp Ala Arg Thr Lys Glu Ala Thr Ser Cys His Arg Ala 
    610                 615                 620                 


Leu Gly Asp Arg Pro Gly Leu Ile Ala Ile Leu Ala Leu Ala Val Leu 
625                 630                 635                 640 


Leu Leu Ala Ala Gly Leu Ala Ala His Leu Gly Thr Gly Gln Pro Arg 
                645                 650                 655     


Lys Gly Val Gly Gly Arg Arg Pro Leu Pro Pro Ala Trp Ala Phe Trp 
            660                 665                 670         


Gly Trp Ser Ala Pro Ser Val Arg Val Val Ser Ala Pro Leu Val Leu 
        675                 680                 685             


Pro Trp Asn Pro Gly Arg Lys Leu Pro Arg Ser Ser Glu Gly Glu Thr 
    690                 695                 700                 


Leu Leu Pro Pro Leu Ser Gln Asn Ser 
705                 710             

<210>  1372
<211>  591
<212>  DNA
<213>  Homo sapiens

<400>  1372
tgtccttaag gctttagtgt ccttttctat gacctgctca cagagtgagt gactgtgagt     60

cttcagtgaa ggagaggaag gtgtatgtgt gtgtatgtgt gtgtgtacat gcacatgtgt    120

gtttgggagg gaaggagagt ggatgggctg aaattattgt tatcttcaga gtccttctga    180

gcccagagag atgtgaggta ggttctctaa cctttcttac ctctttcctc ccagcctcct    240

tggctcactg ggtaaatgga agataaaatg ataagtttcc agaagttcct ctggcagtgt    300

aggtgggagg tgggtgaggg ttggtggaaa taagtacagc ttctaaaatc tgggatgggc    360

tccccaggac cctagaggtg aaaggcagca gacctgacac atccaggcag gctggggtgt    420

tctgctgccc aggatcttct gggtggggat attgctttgg tgtttgccaa cttccccacc    480

ctggaggcag gagtgtttct cctttcccaa cagcctggca gtgttgccca ggaggaggca    540

gtggagttaa gaagcctggg tctgagctcc tcagctgtgc agacaactcc t             591


<210>  1373
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  1373


Met Cys Val Tyr Val Cys Val Tyr Met His Met Cys Val Trp Glu Gly 
1               5                   10                  15      


Arg Arg Val Asp Gly Leu Lys Leu Leu Leu Ser Ser Glu Ser Phe 
            20                  25                  30      

<210>  1374
<211>  553
<212>  DNA
<213>  Homo sapiens

<400>  1374
tttaagttca gtcaccacct gcagaagtct tctccaaaac ctccccacct ggctgactaa     60

ggggctggct ttatgctctt gcagtactca tgcttcctac tgtcacagtt ctgaccacac    120

cgtgggaaaa cgtctctaac tagagacctg tcttgcctct tgtgcctgta gtacgggatg    180

ggtgcccagt gtgtgttgat tgtatgaatc aatctctgtg actccagagt tcctttcttc    240

aggagattag acatcacccc tgcaatcaac aatgcaagcc actgctgttt cctccatcct    300

gagcatgagg aacctatcca gtttctctct cagatgccag ggccatgagg caagtccagc    360

cttggcctag aaccaaagat ggaaacaaaa aggggccaga ctgtgttgcc ttcttgagcc    420

tggtctgact cctgagtgga agtctgattc caggtacatg agataagcac taatacctcc    480

agtttgcaga ttaagagact gaggtcctga agaggttaaa gaacttggct caagtcacat    540

agctggtgag cag                                                       553


<210>  1375
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  1375


Met Gln Ala Thr Ala Val Ser Ser Ile Leu Ser Met Arg Asn Leu Ser 
1               5                   10                  15      


Ser Phe Ser Leu Arg Cys Gln Gly His Glu Ala Ser Pro Ala Leu Ala 
            20                  25                  30          

<210>  1376
<211>  594
<212>  DNA
<213>  Homo sapiens

<400>  1376
aatacctcca gtttgcagat taagagactg aggtcctgaa gaggttaaag aacttggctc     60

aagtcacata gctgggctgt agctataaaa gcttgaaaac cattactctg agaatctctc    120

tgttgggaaa atgagtccct tcaactctag ttgttgccac tgggatgcta acagaaagca    180

aagtctcaga ggaaagatgt ggcattcctg agtgtcttcc atgtaccagg acttctattt    240

gctagccact ttatgttcct catcccatcc ttctgtgagg gacatacttt tcagatgaga    300

aacgtaagct ccgcgaagct aaggggccgg actgaggtcc cacagcgaga gtgtggagga    360

gccaggatcc gaaccccatc gccagccctt gccagttcca tgattccggt gccagcgctc    420

gcctgacctc cagggctgtc atggtgggaa gggactggag ggcatctgct gggcaaagga    480

aagagacaaa catcatccca gagcctgtct tccctgggca atacccgggc cactccagac    540

atggcgtctt tagcccttcc ttggtcactg gcccccaggt gaagagagca tttt          594


<210>  1377
<211>  50
<212>  PRT
<213>  Homo sapiens

<400>  1377


Met Val Gly Arg Asp Trp Arg Ala Ser Ala Gly Gln Arg Lys Glu Thr 
1               5                   10                  15      


Asn Ile Ile Pro Glu Pro Val Phe Pro Gly Gln Tyr Pro Gly His Ser 
            20                  25                  30          


Arg His Gly Val Phe Ser Pro Ser Leu Val Thr Gly Pro Gln Val Lys 
        35                  40                  45              


Arg Ala 
    50  

<210>  1378
<211>  1198
<212>  DNA
<213>  Homo sapiens

<400>  1378
caacttttga tttggttctt gccaattgtt ttatgtccct aaacctcatt tggatccttg     60

gggtatagtt ttatctttct gcttcagtga tttactgtaa cttttcaaat attggttctt    120

tctgtaccat ttaagtatag ttgatatatg tgaggcaaaa aaaggtttca gcatggtggt    180

gagggaaaaa ggagcttaga aatcccagtt ggcacagcct gggcaagcgc cagctcccct    240

cagggctaac ggcactgttc acacagggat cctcagaatc agcggccacc tgcctccacc    300

ttctgcctgg agggcatggg gctgttgtag aacctatggt agcaaatgta tatgtatgag    360

tttgtattct gtagtgttgg tgtagcacag aagaaagacc tgtgtcctag agagtaggcc    420

aaggtgatct gcctcttcta ttgggagaaa ttctaatttc tttcccactt tctcaacaag    480

cccaatattc cctccaagtt cttcttggtg ctgagggctg taggaattat tgaaagcttc    540

tgcctcactt agtatcgtct ggggcccagc acccagcaat aactctaata atgtttctta    600

atggtatagc ctcctgagat taaatgtaaa atcaaaaatt aggaaatctt ggagggagtc    660

ctcaagttgt attgctttgc tgtgcttttg gaagaaggga cgacctggag gacacaggct    720

cctgtgtggg tcttcatcct gcctgaccgg cagatcttcc tctacacctt gggcaaagtc    780

tatgcgaaga tggtttctta gctctccatt tgccatgatt ttcctcccat tcatcatgag    840

ggagtttctc aaaccaggag tttatattta ttttttagaa aatacacact tttcaggaga    900

aacctgagca tgattttgga ttctccacct ccccccagtc tctgcacctg ggattcagct    960

caaggattca gtgtcttcat ttttacaaaa gttcccccaa gaaatcagca accagcctct   1020

gtttcatctg ggagcccctc ccttggcccc ctgtgtggat ttcaggaaga gcctcccttt   1080

ctttgcgtct ccctttcttt aattaacatt ttcaaaagta ataaattctt actgacgact   1140

tgtaacttag tcatatttta tacttgtagc ctttaataaa gccatttaaa aaatgcta     1198


<210>  1379
<211>  88
<212>  PRT
<213>  Homo sapiens

<400>  1379


Met Ile Leu Asp Ser Pro Pro Pro Pro Ser Leu Cys Thr Trp Asp Ser 
1               5                   10                  15      


Ala Gln Gly Phe Ser Val Phe Ile Phe Thr Lys Val Pro Pro Arg Asn 
            20                  25                  30          


Gln Gln Pro Ala Ser Val Ser Ser Gly Ser Pro Ser Leu Gly Pro Leu 
        35                  40                  45              


Cys Gly Phe Gln Glu Glu Pro Pro Phe Leu Cys Val Ser Leu Ser Leu 
    50                  55                  60                  


Ile Asn Ile Phe Lys Ser Asn Lys Phe Leu Leu Thr Thr Cys Asn Leu 
65                  70                  75                  80  


Val Ile Phe Tyr Thr Cys Ser Leu 
                85              

<210>  1380
<211>  3931
<212>  DNA
<213>  Homo sapiens

<400>  1380
cggggggggg cccggaggga ggagctcccg gggagggggc cacggagggc cggggtcccg     60

gggcttgggg agctgggttg gcttggagac ccgggtacgc ggcggtgcag ggcggggttc    120

ccggaggggg cggggctccg ggtggcgcgg ggcggggcga gggcgggcac agcgaggggc    180

ggggcgcggg ccgggagcgg cgggcaggcc gggcatggcg tccatggcgg cggcgatcgc    240

ggcttcgcgc tcggcggtca tgagcgggaa ccggcctctg gacgaccggg agcgaaagcg    300

cttcacttac ttctcgtcgc tgagccccat ggccaggaag atcatgcagg acaaggagaa    360

gatccgcgag aagtacgggc ccgagtgggc gcggctgccg cccgcgcagc aggacgagat    420

catcgaccgg tgcctggtgg ggccgcgcgc cccggcgccc cgagaccccg gggactcgga    480

ggagctcacg cgcttccccg gcttgcgcgg gcccacgggc cagaaggtgg tgcgcttcgg    540

ggacgaggat ctaacttggc aagatgagca ctctgcccct ttctcctggg aaacaaagag    600

tcagatggag ttcagtatct ccgccctatc catccaggag ccgagcaacg gcaccgccgc    660

cagcgagccc agaccactgt ccaaagcttc ccagggctcc caggccctca agtcctccca    720

aggcagcagg tcctccagcc tggacgccct gggccccacc aggaaggagg aggaagcgtc    780

attctggaag atcaatgctg agcggtcccg aggggagggg cctgaggccg agttccagtc    840

gctgacccct agccagatca agtccatgga gaagggggaa aaggtcttgc ctccctgcta    900

ccggcaggaa cctgccccga aggacaggga ggccaaggtg gaaaggccca gcaccctccg    960

tcaggagcag cgtcctcttc ccaacgtgag caccgaacgt gagagacccc agcctgtcca   1020

ggccttcagc agtgcactgc acgaggctgc cccctcccag ctcgagggga agctgccatc   1080

tcctgatgtc aggcaggacg atggggaaga caccctgttc tcggaaccca agtttgcaca   1140

ggtcagctca agtaatgtcg tcttgaagac gggatttgat tttctggaca attggtaaaa   1200

tgtattagaa aaatacaatg aagaacccta aaatgttttc caaagtggtg tggtggagga   1260

ggataaaaag ggccaccttt tcctatgtat tttactggtt tcttgacact cttttcttaa   1320

tcatttggaa actggtcaat attgccagat ttttttcttt tttggtagaa ccagatatat   1380

atgctatttt cagtgatttg ataacagaag ttttccattt ggaattttta aggtctgtta   1440

ataattcagg agatcttgta aataaaactt ctgttcccag ctccacccaa ctttccccct   1500

cctcaaagga tgtgtttcaa ccatgtcaca aaaatcatat aagtgatttc catctccttc   1560

tccattattc cccctccccc ctccgctttt taccgtatgg gttccttttg gtgggtgatt   1620

gagggtgatg ttatcagcca tgacatcagc atgctggctg tgaccccgga aagactggcc   1680

cccagcgacg ttctcagcca gcgctcgcag ctgtccgggg cttctctggc agaagccatg   1740

tctctcacat catgtgccag cctccaccct cacgccattt ccagggaaca gactgcgggt   1800

atgtagcagt gtagtcttta acctgctctg atacatattc agagtatgga ttgttgttta   1860

aaaagagttg catgtttaaa gagttttgta ctagcttttc attattttgt atctagatta   1920

tcaacaatgg ggctaccact ttccttggtt ttatatccat ttcctcttgg aagttcttgt   1980

tgcttatgtg acctgttggt tgttccccgg actgggcacc tacaggagtc agggcagacg   2040

gcagatgtgg ctggaggtca gggctcttct gcttagttgt gttagagtct tccagcatgg   2100

gactgatggg agcagtgggc attctttatc ccaagggcta gccaggttgc gtcatgacgg   2160

accttcccca gccctgacca ccaccagaag tggaagagtg gagtttgcgg tcaactcagc   2220

agtgcccatg gagacctgcg tggtgtcaga gcagcagtat ctcttggagc tggtgcagac   2280

accaaggctg cccagtggta caacgtggtc cacctcccct agggaagctg ctgcactcag   2340

aggctgtcct gcccagtggc ccctgagccg tgtgagcctg caggaggcgt ctgagcagag   2400

cctcaagccc ggtatggcgc catctccatg ttgccatcac tgcgttctca cctgaagcct   2460

taatctttgc gacacctgcc agtgagcgct cggtttcaat accaaagtgt gtcttcttct   2520

tttttttttt tttttaaatg cctgtttcat aggaccttct gaaatgattt ccagaatatt   2580

ttatctggct ccaaaataaa gcacatagca actcacctca acccctcatc atctccagga   2640

aagtttctgc caaagctgtg gcatagccaa cttttgattt ggttcttgcc aattgtttta   2700

tgtccctaaa cctcatttgg atccttgggg tatagtttta tctttctgct tcagtgattt   2760

actgtaactt ttcaaatatt ggttctttct gtaccattta agtatagttg atatatgtga   2820

ggcaaaaaaa ggtttcagca tggtggtgag ggaaaaagga gcttagaaat cccagttggc   2880

acagcctggg caagcgccag ctcccctcag ggctaacggc actgttcaca cagggatcct   2940

cagaatcagc ggccacctgc ctccaccttc tgcctggagg gcatggggct gttgtagaac   3000

ctatggtagc aaatgtatat gtatgagttt gtattctgta gtgttggtgt agcacagaag   3060

aaagacctgt gtcctagaga gtaggccaag gtgatctgcc tcttctattg ggagaaattc   3120

taatttcttt cccactttct caacaagccc aatattccct ccaagttctt cttggtgctg   3180

agggctgtag gaattattga aagcttctgc ctcacttagt atcgtctggg gcccagcacc   3240

cagcaataac tctaataatg tttcttaatg gtatagcctc ctgagattaa atgtaaaatc   3300

aaaaattagg aaatcttgga gggagtcctc aagttgtatt gctttgctgt gcttttggaa   3360

gaagggacga cctggaggac acaggctcct gtgtgggtct tcatcctgcc tgaccggcag   3420

atcttcctct acaccttggg caaagtctat gcgaagatgg tttcttagct ctccatttgc   3480

catgattttc ctcccattca tcatgaggga gtttctcaaa ccaggagttt atatttattt   3540

tttagaaaat acacactttt caggagaaac ctgagcatga ttttggattc tccacctccc   3600

cccagtctct gcacctggga ttcagctcaa ggattcagtg tcttcatttt tacaaaagtt   3660

cccccaagaa atcagcaacc agcctctgtt tcatctggga gcccctccct tggccccctg   3720

ggtttggggg tgctgcccta ctgggaacag cgggggtctg tcacccgtct gagccgcacc   3780

cccctgtgtg gatttcagga agagcctccc tttctttgcg tctccctttc tttaattaac   3840

attttcaaaa gtaataaatt cttactgacg acttgtaact tagtcatatt ttatacttgt   3900

agcctttaat aaagccattt aaaaaatgct a                                  3931


<210>  1381
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  1381


Met Ala Ser Met Ala Ala Ala Ile Ala Ala Ser Arg Ser Ala Val Met 
1               5                   10                  15      


Ser Gly Asn Arg Pro Leu Asp Asp Arg Glu Arg Lys Arg Phe Thr Tyr 
            20                  25                  30          


Phe Ser Ser Leu Ser Pro Met Ala Arg Lys Ile Met Gln Asp Lys Glu 
        35                  40                  45              


Lys Ile Arg Glu Lys Tyr Gly Pro Glu Trp Ala Arg Leu Pro Pro Ala 
    50                  55                  60                  


Gln Gln Asp Glu Ile Ile Asp Arg Cys Leu Val Gly Pro Arg Ala Pro 
65                  70                  75                  80  


Ala Pro Arg Asp Pro Gly Asp Ser Glu Glu Leu Thr Arg Phe Pro Gly 
                85                  90                  95      


Leu Arg Gly Pro Thr Gly Gln Lys Val Val Arg Phe Gly Asp Glu Asp 
            100                 105                 110         


Leu Thr Trp Gln Asp Glu His Ser Ala Pro Phe Ser Trp Glu Thr Lys 
        115                 120                 125             


Ser Gln Met Glu Phe Ser Ile Ser Ala Leu Ser Ile Gln Glu Pro Ser 
    130                 135                 140                 


Asn Gly Thr Ala Ala Ser Glu Pro Arg Pro Leu Ser Lys Ala Ser Gln 
145                 150                 155                 160 


Gly Ser Gln Ala Leu Lys Ser Ser Gln Gly Ser Arg Ser Ser Ser Leu 
                165                 170                 175     


Asp Ala Leu Gly Pro Thr Arg Lys Glu Glu Glu Ala Ser Phe Trp Lys 
            180                 185                 190         


Ile Asn Ala Glu Arg Ser Arg Gly Glu Gly Pro Glu Ala Glu Phe Gln 
        195                 200                 205             


Ser Leu Thr Pro Ser Gln Ile Lys Ser Met Glu Lys Gly Glu Lys Val 
    210                 215                 220                 


Leu Pro Pro Cys Tyr Arg Gln Glu Pro Ala Pro Lys Asp Arg Glu Ala 
225                 230                 235                 240 


Lys Val Glu Arg Pro Ser Thr Leu Arg Gln Glu Gln Arg Pro Leu Pro 
                245                 250                 255     


Asn Val Ser Thr Glu Arg Glu Arg Pro Gln Pro Val Gln Ala Phe Ser 
            260                 265                 270         


Ser Ala Leu His Glu Ala Ala Pro Ser Gln Leu Glu Gly Lys Leu Pro 
        275                 280                 285             


Ser Pro Asp Val Arg Gln Asp Asp Gly Glu Asp Thr Leu Phe Ser Glu 
    290                 295                 300                 


Pro Lys Phe Ala Gln Val Ser Ser Ser Asn Val Val Leu Lys Thr Gly 
305                 310                 315                 320 


Phe Asp Phe Leu Asp Asn Trp 
                325         

<210>  1382
<211>  3815
<212>  DNA
<213>  Homo sapiens

<400>  1382
gtgttcagaa ctatccaggc aaagaccctg gataacagct gaaatgctgg tttttgtttt     60

tgttttttta ttttacgagt ggacacaatt ctcacctgag tccttggcca cgtggcgcta    120

tggcggtcac taccgggaat taaccacggc caccctctca gagcgccggg cgcggactca    180

gggacacgcc ggctaccacc tgagccggcc ccatggccag gaagatcatg caggacaagg    240

agaagatccg cgagaagtac gggcccgagt gggcgcggct gccgcccgcg cagcaggacg    300

agatcatcga ccggtgcctg gtggggccgc gcgccccggc gccccgagac cccggggact    360

cggaggagct cacgcgcttc cccggcttgc gcgggcccac gggccagaag gtggtgcgct    420

tcggggacga ggatctaact tggcaagatg agcactctgc ccctttctcc tgggaaacaa    480

agagtcagat ggagttcagt atctccgccc tatccatcca ggagccgagc aacggcaccg    540

ccgccagcga gcccagacca ctgtccaaag cttcccaggg ctcccaggcc ctcaagtcct    600

cccaaggcag caggtcctcc agcctggacg ccctgggccc caccaggaag gaggaggaag    660

cgtcattctg gaagatcaat gctgagcggt cccgagggga ggggcctgag gccgagttcc    720

agtcgctgac ccctagccag atcaagtcca tggagaaggg ggaaaaggtc ttgcctccct    780

gctaccggca ggaacctgcc ccgaaggaca gggaggccaa ggtggaaagg cccagcaccc    840

tccgtcagga gcagcgtcct cttcccaacg tgagcaccga acgtgagaga ccccagcctg    900

tccaggcctt cagcagtgca ctgcacgagg ctgccccctc ccagctcgag gggaagctgc    960

catctcctga tgtcaggcag gacgatgggg aagacaccct gttctcggaa cccaagtttg   1020

cacaggtcag ctcaagtaat gtcgtcttga agacgggatt tgattttctg gacaattggt   1080

aaaatgtatt agaaaaatac aatgaagaac cctaaaatgt tttccaaagt ggtgtggtgg   1140

aggaggataa aaagggccac cttttcctat gtattttact ggtttcttga cactcttttc   1200

ttaatcattt ggaaactggt caatattgcc agattttttt cttttttggt agaaccagat   1260

atatatgcta ttttcagtga tttgataaca gaagttttcc atttggaatt tttaaggtct   1320

gttaataatt caggagatct tgtaaataaa acttctgttc ccagctccac ccaactttcc   1380

ccctcctcaa aggatgtgtt tcaaccatgt cacaaaaatc atataagtga tttccatctc   1440

cttctccatt attccccctc ccccctccgc tttttaccgt atgggttcct tttggtgggt   1500

gattgagggt gatgttatca gccatgacat cagcatgctg gctgtgaccc cggaaagact   1560

ggcccccagc gacgttctca gccagcgctc gcagctgtcc ggggcttctc tggcagaagc   1620

catgtctctc acatcatgtg ccagcctcca ccctcacgcc atttccaggg aacagactgc   1680

gggtatgtag cagtgtagtc tttaacctgc tctgatacat attcagagta tggattgttg   1740

tttaaaaaga gttgcatgtt taaagagttt tgtactagct tttcattatt ttgtatctag   1800

attatcaaca atggggctac cactttcctt ggttttatat ccatttcctc ttggaagttc   1860

ttgttgctta tgtgacctgt tggttgttcc ccggactggg cacctacagg agtcagggca   1920

gacggcagat gtggctggag gtcagggctc ttctgcttag ttgtgttaga gtcttccagc   1980

atgggactga tgggagcagt gggcattctt tatcccaagg gctagccagg ttgcgtcatg   2040

acggaccttc cccagccctg accaccacca gaagtggaag agtggagttt gcggtcaact   2100

cagcagtgcc catggagacc tgcgtggtgt cagagcagca gtatctcttg gagctggtgc   2160

agacaccaag gctgcccagt ggtacaacgt ggtccacctc ccctagggaa gctgctgcac   2220

tcagaggctg tcctgcccag tggcccctga gccgtgtgag cctgcaggag gcgtctgagc   2280

agagcctcaa gcccggtatg gcgccatctc catgttgcca tcactgcgtt ctcacctgaa   2340

gccttaatct ttgcgacacc tgccagtgag cgctcggttt caataccaaa gtgtgtcttc   2400

ttcttttttt ttttttttta aatgcctgtt tcataggacc ttctgaaatg atttccagaa   2460

tattttatct ggctccaaaa taaagcacat agcaactcac ctcaacccct catcatctcc   2520

aggaaagttt ctgccaaagc tgtggcatag ccaacttttg atttggttct tgccaattgt   2580

tttatgtccc taaacctcat ttggatcctt ggggtatagt tttatctttc tgcttcagtg   2640

atttactgta acttttcaaa tattggttct ttctgtacca tttaagtata gttgatatat   2700

gtgaggcaaa aaaaggtttc agcatggtgg tgagggaaaa aggagcttag aaatcccagt   2760

tggcacagcc tgggcaagcg ccagctcccc tcagggctaa cggcactgtt cacacaggga   2820

tcctcagaat cagcggccac ctgcctccac cttctgcctg gagggcatgg ggctgttgta   2880

gaacctatgg tagcaaatgt atatgtatga gtttgtattc tgtagtgttg gtgtagcaca   2940

gaagaaagac ctgtgtccta gagagtaggc caaggtgatc tgcctcttct attgggagaa   3000

attctaattt ctttcccact ttctcaacaa gcccaatatt ccctccaagt tcttcttggt   3060

gctgagggct gtaggaatta ttgaaagctt ctgcctcact tagtatcgtc tggggcccag   3120

cacccagcaa taactctaat aatgtttctt aatggtatag cctcctgaga ttaaatgtaa   3180

aatcaaaaat taggaaatct tggagggagt cctcaagttg tattgctttg ctgtgctttt   3240

ggaagaaggg acgacctgga ggacacaggc tcctgtgtgg gtcttcatcc tgcctgaccg   3300

gcagatcttc ctctacacct tgggcaaagt ctatgcgaag atggtttctt agctctccat   3360

ttgccatgat tttcctccca ttcatcatga gggagtttct caaaccagga gtttatattt   3420

attttttaga aaatacacac ttttcaggag aaacctgagc atgattttgg attctccacc   3480

tccccccagt ctctgcacct gggattcagc tcaaggattc agtgtcttca tttttacaaa   3540

agttccccca agaaatcagc aaccagcctc tgtttcatct gggagcccct cccttggccc   3600

cctgggtttg ggggtgctgc cctactggga acagcggggg tctgtcaccc gtctgagccg   3660

cacccccctg tgtggatttc aggaagagcc tccctttctt tgcgtctccc tttctttaat   3720

taacattttc aaaagtaata aattcttact gacgacttgt aacttagtca tattttatac   3780

ttgtagcctt taataaagcc atttaaaaaa tgcta                              3815


<210>  1383
<211>  289
<212>  PRT
<213>  Homo sapiens

<400>  1383


Met Ala Arg Lys Ile Met Gln Asp Lys Glu Lys Ile Arg Glu Lys Tyr 
1               5                   10                  15      


Gly Pro Glu Trp Ala Arg Leu Pro Pro Ala Gln Gln Asp Glu Ile Ile 
            20                  25                  30          


Asp Arg Cys Leu Val Gly Pro Arg Ala Pro Ala Pro Arg Asp Pro Gly 
        35                  40                  45              


Asp Ser Glu Glu Leu Thr Arg Phe Pro Gly Leu Arg Gly Pro Thr Gly 
    50                  55                  60                  


Gln Lys Val Val Arg Phe Gly Asp Glu Asp Leu Thr Trp Gln Asp Glu 
65                  70                  75                  80  


His Ser Ala Pro Phe Ser Trp Glu Thr Lys Ser Gln Met Glu Phe Ser 
                85                  90                  95      


Ile Ser Ala Leu Ser Ile Gln Glu Pro Ser Asn Gly Thr Ala Ala Ser 
            100                 105                 110         


Glu Pro Arg Pro Leu Ser Lys Ala Ser Gln Gly Ser Gln Ala Leu Lys 
        115                 120                 125             


Ser Ser Gln Gly Ser Arg Ser Ser Ser Leu Asp Ala Leu Gly Pro Thr 
    130                 135                 140                 


Arg Lys Glu Glu Glu Ala Ser Phe Trp Lys Ile Asn Ala Glu Arg Ser 
145                 150                 155                 160 


Arg Gly Glu Gly Pro Glu Ala Glu Phe Gln Ser Leu Thr Pro Ser Gln 
                165                 170                 175     


Ile Lys Ser Met Glu Lys Gly Glu Lys Val Leu Pro Pro Cys Tyr Arg 
            180                 185                 190         


Gln Glu Pro Ala Pro Lys Asp Arg Glu Ala Lys Val Glu Arg Pro Ser 
        195                 200                 205             


Thr Leu Arg Gln Glu Gln Arg Pro Leu Pro Asn Val Ser Thr Glu Arg 
    210                 215                 220                 


Glu Arg Pro Gln Pro Val Gln Ala Phe Ser Ser Ala Leu His Glu Ala 
225                 230                 235                 240 


Ala Pro Ser Gln Leu Glu Gly Lys Leu Pro Ser Pro Asp Val Arg Gln 
                245                 250                 255     


Asp Asp Gly Glu Asp Thr Leu Phe Ser Glu Pro Lys Phe Ala Gln Val 
            260                 265                 270         


Ser Ser Ser Asn Val Val Leu Lys Thr Gly Phe Asp Phe Leu Asp Asn 
        275                 280                 285             


Trp 
    

<210>  1384
<211>  3942
<212>  DNA
<213>  Homo sapiens

<400>  1384
acttttgtgt tcagaactat ccaggcaaag accctggata acagctgaaa tgctggtttt     60

tgtttttgtt tttttatttt acgagtggac acaattctca cctgagtcct gttagtcttg    120

ttaaaatcag tcagatggag agaggggctt gggggaagtg ggggctcgct ataattttaa    180

ttttgtggtc tgtctgggac acacctcaaa attacaaacc ctggccccct acctgttggg    240

atgtcgcctc tgagtctgaa aactttctgc tcctctttgg tttgtttgca aacgtcgaac    300

tgccaagagt tctgagctcc ttgggttggg gaaaggcacc tgggccaccg ggtacttcat    360

gcacccacct ggccccgagg ggcggcggga gctgactttc cttgagcacc agatgccccg    420

aaccggtcca gccttccagg tcgccctcca gcctccgggc tgccctgcgc ccccggctat    480

ctgcagctca ccgcgccagg ccccgggccc agcgtcctgg acgggcccag agaaagcaga    540

gaagtggcca cgtggcgcta tggcggtcac taccgggaat taaccacggc caccctctca    600

gagcgccggg cgcggactca gggacacgcc ggctaccacc tgagccggga gccgagcaac    660

ggcaccgccg ccagcgagcc cagaccactg tccaaagctt cccagggctc ccaggccctc    720

aagtcctccc aaggcagcag gtcctccagc ctggacgccc tgggccccac caggaaggag    780

gaggaagcgt cattctggaa gatcaatgct gagcggtccc gaggggaggg gcctgaggcc    840

gagttccagt cgctgacccc tagccagatc aagtccatgg agaaggggga aaaggtcttg    900

cctccctgct accggcagga acctgccccg aaggacaggg aggccaaggt ggaaaggccc    960

agcaccctcc gtcaggagca gcgtcctctt cccaacgtga gcaccgaacg tgagagaccc   1020

cagcctgtcc aggccttcag cagtgcactg cacgaggctg ccccctccca gctcgagggg   1080

aagctgccat ctcctgatgt caggcaggac gatggggaag acaccctgtt ctcggaaccc   1140

aagtttgcac aggtcagctc aagtaatgtc gtcttgaaga cgggatttga ttttctggac   1200

aattggtaaa atgtattaga aaaatacaat gaagaaccct aaaatgtttt ccaaagtggt   1260

gtggtggagg aggataaaaa gggccacctt ttcctatgta ttttactggt ttcttgacac   1320

tcttttctta atcatttgga aactggtcaa tattgccaga tttttttctt ttttggtaga   1380

accagatata tatgctattt tcagtgattt gataacagaa gttttccatt tggaattttt   1440

aaggtctgtt aataattcag gagatcttgt aaataaaact tctgttccca gctccaccca   1500

actttccccc tcctcaaagg atgtgtttca accatgtcac aaaaatcata taagtgattt   1560

ccatctcctt ctccattatt ccccctcccc cctccgcttt ttaccgtatg ggttcctttt   1620

ggtgggtgat tgagggtgat gttatcagcc atgacatcag catgctggct gtgaccccgg   1680

aaagactggc ccccagcgac gttctcagcc agcgctcgca gctgtccggg gcttctctgg   1740

cagaagccat gtctctcaca tcatgtgcca gcctccaccc tcacgccatt tccagggaac   1800

agactgcggg tatgtagcag tgtagtcttt aacctgctct gatacatatt cagagtatgg   1860

attgttgttt aaaaagagtt gcatgtttaa agagttttgt actagctttt cattattttg   1920

tatctagatt atcaacaatg gggctaccac tttccttggt tttatatcca tttcctcttg   1980

gaagttcttg ttgcttatgt gacctgttgg ttgttccccg gactgggcac ctacaggagt   2040

cagggcagac ggcagatgtg gctggaggtc agggctcttc tgcttagttg tgttagagtc   2100

ttccagcatg ggactgatgg gagcagtggg cattctttat cccaagggct agccaggttg   2160

cgtcatgacg gaccttcccc agccctgacc accaccagaa gtggaagagt ggagtttgcg   2220

gtcaactcag cagtgcccat ggagacctgc gtggtgtcag agcagcagta tctcttggag   2280

ctggtgcaga caccaaggct gcccagtggt acaacgtggt ccacctcccc tagggaagct   2340

gctgcactca gaggctgtcc tgcccagtgg cccctgagcc gtgtgagcct gcaggaggcg   2400

tctgagcaga gcctcaagcc cggtatggcg ccatctccat gttgccatca ctgcgttctc   2460

acctgaagcc ttaatctttg cgacacctgc cagtgagcgc tcggtttcaa taccaaagtg   2520

tgtcttcttc tttttttttt ttttttaaat gcctgtttca taggaccttc tgaaatgatt   2580

tccagaatat tttatctggc tccaaaataa agcacatagc aactcacctc aacccctcat   2640

catctccagg aaagtttctg ccaaagctgt ggcatagcca acttttgatt tggttcttgc   2700

caattgtttt atgtccctaa acctcatttg gatccttggg gtatagtttt atctttctgc   2760

ttcagtgatt tactgtaact tttcaaatat tggttctttc tgtaccattt aagtatagtt   2820

gatatatgtg aggcaaaaaa aggtttcagc atggtggtga gggaaaaagg agcttagaaa   2880

tcccagttgg cacagcctgg gcaagcgcca gctcccctca gggctaacgg cactgttcac   2940

acagggatcc tcagaatcag cggccacctg cctccacctt ctgcctggag ggcatggggc   3000

tgttgtagaa cctatggtag caaatgtata tgtatgagtt tgtattctgt agtgttggtg   3060

tagcacagaa gaaagacctg tgtcctagag agtaggccaa ggtgatctgc ctcttctatt   3120

gggagaaatt ctaatttctt tcccactttc tcaacaagcc caatattccc tccaagttct   3180

tcttggtgct gagggctgta ggaattattg aaagcttctg cctcacttag tatcgtctgg   3240

ggcccagcac ccagcaataa ctctaataat gtttcttaat ggtatagcct cctgagatta   3300

aatgtaaaat caaaaattag gaaatcttgg agggagtcct caagttgtat tgctttgctg   3360

tgcttttgga agaagggacg acctggagga cacaggctcc tgtgtgggtc ttcatcctgc   3420

ctgaccggca gatcttcctc tacaccttgg gcaaagtcta tgcgaagatg gtttcttagc   3480

tctccatttg ccatgatttt cctcccattc atcatgaggg agtttctcaa accaggagtt   3540

tatatttatt ttttagaaaa tacacacttt tcaggagaaa cctgagcatg attttggatt   3600

ctccacctcc ccccagtctc tgcacctggg attcagctca aggattcagt gtcttcattt   3660

ttacaaaagt tcccccaaga aatcagcaac cagcctctgt ttcatctggg agcccctccc   3720

ttggccccct gggtttgggg gtgctgccct actgggaaca gcgggggtct gtcacccgtc   3780

tgagccgcac ccccctgtgt ggatttcagg aagagcctcc ctttctttgc gtctcccttt   3840

ctttaattaa cattttcaaa agtaataaat tcttactgac gacttgtaac ttagtcatat   3900

tttatacttg tagcctttaa taaagccatt taaaaaatgc ta                      3942


<210>  1385
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  1385


Met Glu Lys Gly Glu Lys Val Leu Pro Pro Cys Tyr Arg Gln Glu Pro 
1               5                   10                  15      


Ala Pro Lys Asp Arg Glu Ala Lys Val Glu Arg Pro Ser Thr Leu Arg 
            20                  25                  30          


Gln Glu Gln Arg Pro Leu Pro Asn Val Ser Thr Glu Arg Glu Arg Pro 
        35                  40                  45              


Gln Pro Val Gln Ala Phe Ser Ser Ala Leu His Glu Ala Ala Pro Ser 
    50                  55                  60                  


Gln Leu Glu Gly Lys Leu Pro Ser Pro Asp Val Arg Gln Asp Asp Gly 
65                  70                  75                  80  


Glu Asp Thr Leu Phe Ser Glu Pro Lys Phe Ala Gln Val Ser Ser Ser 
                85                  90                  95      


Asn Val Val Leu Lys Thr Gly Phe Asp Phe Leu Asp Asn Trp 
            100                 105                 110 

<210>  1386
<211>  1219
<212>  DNA
<213>  Homo sapiens

<400>  1386
tgtcgtcttg aagacgggat ttgattttct ggacaattgg taaaatgtat tagaaaaata     60

caatgaagaa ccctaaaatg ttttccaaag tggtgtggtg gaggaggata aaaagggcca    120

ccttttccta tgtattttac tggtttcttg acactctttt cttaatcatt tggaaactgg    180

tcaatattgc cagatttttt tcttttttgg tagaaccaga tatatatgct attttcagtg    240

atttgataac agaagttttc catttggaat ttttaaggtc tgttaataat tcaggagatc    300

ttgtaaataa aacttctgtt cccagctcca cccaactttc cccctcctca aaggatgtgt    360

ttcaaccatg tcacaaaaat catataagtg atttccatct ccttctccat tattccccct    420

cccccctccg ctttttaccg tatgggttcc ttttggtggg tgattgaggg tgatgttatc    480

agccatgaca tcagcatgct ggctgtgacc ccggaaagac tggcccccag cgacgttctc    540

agccagcgct cgcagctgtc cggggcttct ctggcagaag ccatgtctct cacatcatgt    600

gccagcctcc accctcacgc catttccagg gaacagactg cgggtatgta gcagtgtagt    660

ctttaacctg ctctgataca tattcagagt atggattgtt gtttaaaaag agttgcatgt    720

ttaaagagtt ttgtactagc ttttcattat tttgtatcta gattatcaac aatggggcta    780

ccactttcct tggttttata tccatttcct cttggaagtt cttgttgctt atgtgacctg    840

ttggttgttc cccggactgg gcacctacag gagtcagggc agacggcaga tgtggctgga    900

ggtcagggct cttctgctta gttgtgttag agtcttccag catgggactg atgggagcag    960

tgggcattct ttatcccaag ggctagccag gttgcgtcat gacggacctt ccccagccct   1020

gaccaccacc agaagtggaa gagtggagtt tgcggtcaac tcagcagtgc ccatggagac   1080

ctgcgtggtg tcagagcagc agtatctctt ggagctggtg cagacaccaa ggctgcccag   1140

tggtacaacg tggtccacct cccctaggga agctgcttaa tctttgcgac acctgccagt   1200

gagcgctcgg tttcaatac                                                1219


<210>  1387
<211>  96
<212>  PRT
<213>  Homo sapiens

<400>  1387


Met Trp Leu Glu Val Arg Ala Leu Leu Leu Ser Cys Val Arg Val Phe 
1               5                   10                  15      


Gln His Gly Thr Asp Gly Ser Ser Gly His Ser Leu Ser Gln Gly Leu 
            20                  25                  30          


Ala Arg Leu Arg His Asp Gly Pro Ser Pro Ala Leu Thr Thr Thr Arg 
        35                  40                  45              


Ser Gly Arg Val Glu Phe Ala Val Asn Ser Ala Val Pro Met Glu Thr 
    50                  55                  60                  


Cys Val Val Ser Glu Gln Gln Tyr Leu Leu Glu Leu Val Gln Thr Pro 
65                  70                  75                  80  


Arg Leu Pro Ser Gly Thr Thr Trp Ser Thr Ser Pro Arg Glu Ala Ala 
                85                  90                  95      

<210>  1388
<211>  1281
<212>  DNA
<213>  Homo sapiens

<400>  1388
acttttgtgt tcagaactat ccaggcaaag accctggata acagctgaaa tgctggtttt     60

tgtttttgtt tttttatttt acgagtggac acaattctca cctgagtcct gttagtcttg    120

ttaaaatcag tcagatggag agaggggctt gggggaagtg ggggctcgct ataattttaa    180

ttttgtggtc tgtctgggac acacctcaaa attacaaacc ctggccccct acctgttggg    240

atgtcgcctc tgagtctgaa aactttctgc tcctctttgg tttgtttgca aacgtcgaac    300

tgccaagagt tctgagctcc ttgggttggg gaaaggcacc tgggccaccg ggtacttcat    360

gcacccacct ggccccgagg ggcggcggga gctgactttc cttgagcacc agatgccccg    420

aaccggtcca gccttccagg tcgccctcca gcctccgggc tgccctgcgc ccccggctat    480

ctgcagctca ccgcgccagg ccccgggccc agcgtcctgg acgggcccag agaaagcaga    540

gaagtggcca cgtggcgcta tggcggtcac taccgggaat taaccacggc caccctctca    600

gagcgccggg cgcggactca gggacacgcc ggctaccacc tgagccgggt aaggggagcc    660

cgaaacctgc gggcaccgcg gtaatccact atggaggcgt aaagggggac tcgtggggtc    720

cgcgaggggg tggcgggggg gggcccggag ggaggagctc ccggggaggg ggccacggag    780

ggccggggtc ccggggcttg gggagctggg ttggcttgga gacccgggta cgcggcggtg    840

cagggcgggg ttcccggagg gggcggggct ccgggtggcg cggggcgggg cgagggcggg    900

cacagcgagg ggcggggcgc gggccgggag cggcgggcag gccgggcatg gcgtccatgg    960

cggcggcgat cgcggcttcg cgctcggcgg tcatgagcgg gaaccggcct ctggacgacc   1020

gggagcgaaa gcgcttcact tacttctcgt cgctgagccc catggccagg aagatcatgc   1080

aggacaagga gaagatccgc gagaagtacg ggcccgagtg ggcgcggctg ccgcccgcgc   1140

agcaggacga gatcatcgac cggtgcctgg tggggccgcg cgccccggcg ccccgagacc   1200

ccggggactc ggaggagctc acgcgcttcc ccggcttgcg cgggcccacg ggccagaagg   1260

tggtgcgctt cggggacgag g                                             1281


<210>  1389
<211>  74
<212>  PRT
<213>  Homo sapiens

<400>  1389


Met His Pro Pro Gly Pro Glu Gly Arg Arg Glu Leu Thr Phe Leu Glu 
1               5                   10                  15      


His Gln Met Pro Arg Thr Gly Pro Ala Phe Gln Val Ala Leu Gln Pro 
            20                  25                  30          


Pro Gly Cys Pro Ala Pro Pro Ala Ile Cys Ser Ser Pro Arg Gln Ala 
        35                  40                  45              


Pro Gly Pro Ala Ser Trp Thr Gly Pro Glu Lys Ala Glu Lys Trp Pro 
    50                  55                  60                  


Arg Gly Ala Met Ala Val Thr Thr Gly Asn 
65                  70                  

<210>  1390
<211>  809
<212>  DNA
<213>  Homo sapiens

<400>  1390
aacccagctc cccaagcccc gggaccccgg ccctccgtgg ccccctcccc gggagctcct     60

ccctccgggc ccccccccgc caccccctcg cggaccccac gagtccccct ttacgcctcc    120

atagtggatt accgcggtgc ccgcaggttt cgggctcccc ttacccggct caggtggtag    180

ccggcgtgtc cctgagtccg cgcccggcgc tctgagaggg tggccgtggt taattcccgg    240

tagtgaccgc catagcgcca cgtggccact gcttgacaaa ggaaactttt ttcaacctcc    300

agtgagccta agaaagcccc agcatttcag gccaagccgc tggctgcctg gcttctgttt    360

ttactccttt ccttctgtcc ctttctggga cgagccacac cttctctgct ttctctgggc    420

ccgtccagga cgctgggccc ggggcctggc gcggtgagct gcagatagcc gggggcgcag    480

ggcagcccgg aggctggagg gcgacctgga aggctggacc ggttcggggc atctggtgct    540

caaggaaagt cagctcccgc cgcccctcgg ggccagcttg gcttgaagga gtactttagg    600

actcagaaca acaggatgaa gacagcagct aaaatagaac acaccagcag agacgttcag    660

ctccttgagc tgtgcttccg aagctcaagc atggcagagt ggccttgtta aatcagagtt    720

cagggtgcca ccctgacagt ttctgattcc gtaggtgccc agtagggacc aagaatcctt    780

tttttttttc ctttttcttt ttaatagag                                      809


<210>  1391
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  1391


Met Lys Thr Ala Ala Lys Ile Glu His Thr Ser Arg Asp Val Gln Leu 
1               5                   10                  15      


Leu Glu Leu Cys Phe Arg Ser Ser Ser Met Ala Glu Trp Pro Cys 
            20                  25                  30      

<210>  1392
<211>  963
<212>  DNA
<213>  Homo sapiens

<400>  1392
aacccagctc cccaagcccc gggaccccgg ccctccgtgg ccccctcccc gggagctcct     60

ccctccgggc ccccccccgc caccccctcg cggaccccac gagtccccct ttacgcctcc    120

atagtggatt accgcggtgc ccgcaggttt cgggctcccc ttacccggct caggtggtag    180

ccggcgtgtc cctgagtccg cgcccggcgc tctgagaggg tggccgtggt taattcccgg    240

tagtgaccgc catagcgcca cgtggccact gcttgacaaa ggaaactttt ttcaacctcc    300

agtgagccta agaaagcccc agcatttcag gccaagccgc tggctgcctg gcttctgttt    360

ttactccttt ccttctgtcc ctttctggga cgagccacac cttctctgct ttctctgggc    420

ccgtccagga cgctgggccc ggggcctggc gcggtgagct gcagatagcc gggggcgcag    480

ggcagcccgg aggctggagg gcgacctgga aggctggacc ggttcggggc atctggtgct    540

caaggaaagt cagctcccgc cgcccctcgg ggccaggtgg gtgcatgaag tacccggtgg    600

cccaggtgcc tttccccaac ccaaggagct cagaactctt ggcagttcga cgtttgcaaa    660

caaaccaaag aggagcagaa agttttcaga ctcagaggcg acatcccaac agcttggctt    720

gaaggagtac tttaggactc agaacaacag gatgaagaca gcagctaaaa tagaacacac    780

cagcagagac gttcagctcc ttgagctgtg cttccgaagc tcaagcatgg cagagtggcc    840

ttgttaaatc agagttcagg gtgccaccct gacagtttct gattccgtag gtgcccagta    900

gggaccaaga atcctttttt tttttccttt ttctttttaa tagagtcagg gtcttgctat    960

gtt                                                                  963


<210>  1393
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  1393


Met Lys Tyr Pro Val Ala Gln Val Pro Phe Pro Asn Pro Arg Ser Ser 
1               5                   10                  15      


Glu Leu Leu Ala Val Arg Arg Leu Gln Thr Asn Gln Arg Gly Ala Glu 
            20                  25                  30          


Ser Phe Gln Thr Gln Arg Arg His Pro Asn Ser Leu Ala 
        35                  40                  45  

<210>  1394
<211>  794
<212>  DNA
<213>  Homo sapiens

<400>  1394
ctggaattcc aggcataagc caccgtgcct ggccaagaac gttttttttt ttaacaagtt     60

tctaaatgat gctggtctat tggtcctggg accacacttt gaaattggtg ggataggagg    120

ctgggatctt tatccattca ctcaactccc attccccatg gttgaaagtt tccctggggc    180

atccctggga ggcctggggg ctgacaagat tcaaacgttt tggtgaaaag ccccaagaca    240

gtgaagtggg gtgtgcttga agtggggcac cgtcatcacc cacctaccca ccacagaggt    300

gagctaaaag gttaccagac cggagcctcc agcaatccag gagcacaaac aaggatgcct    360

taaaacaaaa cttgtgtcag ggtacccttc gctgcctcag aggaaatcag aatgacctgg    420

tggacaactg ttcataagga caagagccag tatcactgcc tttgagtccc agcctcctca    480

aatccatttt ctgccctgca ccacctcatc atatcccgga tattgttagt gtcgtgtcat    540

ttcatgactc aggagctgcg ggtgactttg gctgccctga catttgttaa attggctcct    600

gggtcctggt ttgcaaatgt tgccactttg agatccgtag atggtcatcc ctggctccct    660

tggggagtgt cctggaatcc accagctcca tctgctcgac aagagacttg agtttgttct    720

gttacctctt tcatcattag ccaaagctcc gggacttggt taaaacttta ggcaattaaa    780

aagactgact tatg                                                      794


<210>  1395
<211>  55
<212>  PRT
<213>  Homo sapiens

<400>  1395


Met Thr Gln Glu Leu Arg Val Thr Leu Ala Ala Leu Thr Phe Val Lys 
1               5                   10                  15      


Leu Ala Pro Gly Ser Trp Phe Ala Asn Val Ala Thr Leu Arg Ser Val 
            20                  25                  30          


Asp Gly His Pro Trp Leu Pro Trp Gly Val Ser Trp Asn Pro Pro Ala 
        35                  40                  45              


Pro Ser Ala Arg Gln Glu Thr 
    50                  55  

<210>  1396
<211>  16235
<212>  DNA
<213>  Homo sapiens

<400>  1396
gcgcggcccc ctccagcccc cggctcccgg cagcagaagc agaaggcagc gccaggggcc     60

gccgccgccg ccgagctccg cggggctcgg gagccggccc cggcgaggag gcgcggaacc    120

atggccgatg ggggcgaggg cgaagacgag atccagttcc tgcgaactga gaatgtgccc    180

ccagacctct ccatctgcac ctttgtgctg gagcagtccc tctctgtccg ggcgctgcag    240

gagatgctgg ctaacaccgt ggagaaatca gaaggggcaa ttgatgtgga aaaatggact    300

gctcaaggtg gtggtcatcg aacactcctc tacggacatg ccatattgct gcgccattcc    360

tatagtggca tgtatctgtg ctgcctgtcc acctcccggt cttcaactga taagctggct    420

tttgatgttg gcttgcaaga ggacaccaca ggggaggctt gttggtggac catacaccct    480

gcctctaagc agcgatcaga aggagaaaaa gtacgagttg gagatgacct catcttagtt    540

agcgtgtcct ctgaaaggta cttgcacttg tcttatggca acggcagctt acacgtggat    600

gccgctttcc agcagactct ctggagcgtg gccccaatca gctcaggaag tgaggcagcc    660

caagggtatc tcattggtgg tgatgtcctc aggttgctgc atggacacat ggacgagtgt    720

ctcactgtcc cttcaggaga acatggtgaa gagcagcgga gaactgttca ttatgaaggt    780

ggcgctgtgt ctgttcatgc acgttccctt tggagactag agacgctaag agttgcgtgg    840

agtggaagcc acataagatg gggacagcca ttccgactac gccatgtcac aacaggaaaa    900

tacttgagtc tcatggaaga caaaaacctt ctactcatgg acaaagagaa agctgatgta    960

aaatcaacag catttacctt ccggtcttcc aaggaaaaat tggatgtagg ggtgagaaaa   1020

gaagtagatg gcatgggaac atctgaaata aaatacggtg actcagtatg ctatatacaa   1080

catgtagaca caggcctatg gcttacttac cagtctgtgg acgtgaaatc cgtgagaatg   1140

ggatctatac aacgtaaggc tattatgcat catgaaggcc acatggatga tggcataagt   1200

ttgtcgagat cccagcatga agaatcacgc acagcccgag ttatccggag cacagtcttc   1260

cttttcaata gatttataag gggccttgat gctctcagca agaaagcgaa ggcttccaca   1320

gtcgatttgc ctatagagtc cgtaagccta agtctgcagg atctcattgg ctacttccac   1380

cccccagatg agcatttaga gcatgaagac aaacagaaca gactacgagc cctgaagaat   1440

cggcaaaatc tcttccagga agagggaatg atcaacctcg tgcttgagtg catagaccgt   1500

ttgcacgtct acagcagtgc agcacacttt gctgatgttg ctgggcgaga agcaggagag   1560

tcttggaaat ccattctgaa ttctctgtat gagttgctgg cggctctaat tagaggaaat   1620

cgtaaaaact gtgctcaatt ttctggctcc ctcgactggt tgatcagcag attggaaaga   1680

ctggaagctt cttcaggcat tctggaagtt ttacactgtg ttttagtaga aagtccagaa   1740

gctctaaata ttattaaaga aggacatatt aaatctatta tctcactttt agacaaacat   1800

ggaagaaatc acaaggttct ggatgtcttg tgctcactct gtgtttgcca cggggttgca   1860

gtccgttcta accagcatct catctgtgac aatctcctac caggaagaga cttgttattg   1920

cagacacgtc ttgtgaacca tgtcagcagc atgagaccca atatttttct gggcgtcagt   1980

gaaggttctg ctcagtataa gaaatggtac tatgaattga tggtggacca cacagagccc   2040

tttgtgacag ctgaagcaac tcacctgcga gtgggctggg cttccactga aggatattct   2100

ccctaccctg gagggggcga agagtggggt ggaaatggtg ttggagatga tctcttctcc   2160

tatggatttg atggccttca tctctggtca ggttgtattg ctcgtactgt aagctcacca   2220

aaccaacatc tgttaagaac tgatgatgtc atcagttgct gtttagatct gagtgcccca   2280

agcatctcgt tccgaattaa tggacaacct gttcaaggaa tgtttgagaa tttcaacatc   2340

gatggcctct tctttccagt cgttagtttc tctgcaggaa taaaagtacg ctttctgctt   2400

ggagggcgac atggagaatt caaatttctt cctccacctg ggtatgctcc ttgttatgaa   2460

gctgttctgc caaaagaaaa gttgaaagtg gaacacagcc gagagtacaa gcaagaaaga   2520

acttacacac gcgacctgct gggccccaca gtttccctga cgcaagctgc cttcacaccc   2580

atccctgtgg ataccagcca gatcgtgttg cctcctcatc tagaaagaat aagagaaaaa   2640

ctggcagaga atatccatga actctgggtt atgaataaaa ttgagcttgg ctggcagtat   2700

ggtccggtta gagatgacaa caagagacaa cacccatgcc tggtggagtt ctccaagctg   2760

cctgaacagg agcgcaatta caacttacaa atgtcgcttg agaccctgaa gactttgttg   2820

gcattaggat gtcatgtggg tatatcagat gaacatgctg aagacaaggt gaaaaaaatg   2880

aagctaccca agaattacca gctgacaagt ggatacaagc ctgcccctat ggacctgagc   2940

tttatcaaac tcaccccatc acaagaagca atggtggaca agttggcaga aaatgcacat   3000

aatgtgtggg cgcgggatcg aatccggcag ggctggactt atggcatcca acaggacgta   3060

aagaacagaa gaaatcctcg ccttgttccc tacactcttc tggatgaccg aaccaagaaa   3120

tccaacaagg acagcctccg cgaggctgtg cgcacgctgc tggggtacgg ctacaacttg   3180

gaagcaccag atcaagatca tgcagccaga gccgaagtgt gcagcggcac cggggaaagg   3240

ttccgaatct tccgtgccga gaagacctat gcagtgaagg ccggacggtg gtattttgaa   3300

tttgagacgg tcactgctgg agacatgagg gttggttgga gtcgtcctgg ttgtcaaccg   3360

gatcaggagc ttggctcaga tgaacgtgcc tttgcctttg atggcttcaa ggcccagcgg   3420

tggcatcagg gcaatgaaca ctatgggcgc tcttggcaag caggcgatgt cgtggggtgt   3480

atggttgaca tgaacgaaca caccatgatg ttcacactga atggtgaaat ccttcttgat   3540

gattcaggct cagaactggc tttcaaggac tttgatgttg gcgatggatt catacctgtg   3600

tgtagccttg gagtggctca agtgggtagg atgaactttg gaaaggatgt cagcaccttg   3660

aaatatttca ccatctgtgg cttacaagag ggctatgaac catttgccgt taatacaaac   3720

agggatatta ccatgtggct gagcaagagg cttcctcagt ttcttcaagt tccatcaaac   3780

catgaacata tagaggtgac cagaatagac ggcaccatag acagttcccc atgtttaaag   3840

gtcactcaga agtcttttgg ttctcagaac agcaacactg atatcatgtt ttatcgcctg   3900

agcatgccga tcgagtgcgc ggaggtcttc tccaagacgg tggctggagg gctccctggg   3960

gctggccttt ttgggcccaa gaatgacttg gaagattatg atgctgattc tgactttgag   4020

gttctgatga agacagctca tggccatcta gtgcccgatc gtgttgacaa agacaaagaa   4080

gctactaaac cagagtttaa caaccacaaa gattatgccc aggaaaagcc ctctcgtctg   4140

aaacaaagat ttttgcttag aagaacaaag ccagattaca gcacaagcca ttctgcaaga   4200

ctcaccgaag atgtccttgc tgatgatcgg gatgactatg atttcttgat gcaaacgtcc   4260

acgtactatt actcagtgag aatctttcct ggacaagaac ctgctaatgt ctgggtgggc   4320

tggattacat cagatttcca tcagtatgac acaggctttg acttggacag agttcgcaca   4380

gtaacagtta ctctaggaga tgaaaaagga aaagtgcatg aaagcatcaa acgcagcaac   4440

tgctatatgg tatgtgcggg tgagagcatg agccccgggc aaggacgcaa caataatgga   4500

ctggagattg gctgtgtggt ggatgctgcc agcgggctgc tcacattcat tgccaatggc   4560

aaggaactga gcacatacta tcaggtggaa ccgagtacaa aattatttcc tgcggttttt   4620

gcacaagcta caagtcccaa tgttttccag tttgagttgg gaagaataaa gaatgtgatg   4680

cctctctcgg cgggattatt caagagtgag cacaagaacc ccgtgccgca gtgccccccg   4740

cgcctccacg tgcagttcct gtcacacgtc ctgtggagca gaatgcccaa ccagtttttg   4800

aaggtagatg tgtctcgaat aagtgaacgc caaggctggt tggtgcagtg tttggatcct   4860

ctgcagttca tgtctcttca tatccctgag gaaaacagat ctgttgacat cttagagttg   4920

acagagcagg aggaattgct gaaatttcac tatcacactc tccggctcta ctcagccgtc   4980

tgtgctcttg ggaaccaccg ggtggcccat gccctgtgca gccatgtgga tgaacctcag   5040

ctcctctatg ccattgagaa caagtacatg cctggtttgc tgcgtgctgg ctactatgac   5100

ctgctgattg acatccacct gagctcctat gccactgcca ggctcatgat gaacaacgag   5160

tacattgtcc ccatgacgga ggagacgaag agcatcaccc tgttccctga tgagaacaaa   5220

aaacacggcc ttccagggat cggcctcagc acctccctca ggccacggat gcagttttcc   5280

tcccccagtt ttgtaagcat tagtaatgaa tgttaccagt acagtccaga gttcccactg   5340

gacatcctca agtccaaaac catacagatg ctgacagaag ctgttaaaga gggcagtctt   5400

catgcccggg acccagttgg agggactact gaattcctct ttgtacctct catcaagctt   5460

ttctataccc tgctgatcat gggcatcttt cacaacgagg acttgaagca catcttgcag   5520

ttgattgagc ccagtgtgtt taaagaagct gccactccgg aggaggagag tgacacgctg   5580

gagaaagagc tcagtgtgga cgatgcaaag ctgcaaggag ctggtgagga agaagccaag   5640

gggggcaagc ggcccaagga aggcctgctc caaatgaaac tgccagagcc agttaaattg   5700

cagatgtgcc tactgcttca gtacctctgt gactgccagg tccggcaccg gatagaagcc   5760

attgtagcct tttcagatga ttttgtggct aagctccaag acaatcaacg tttccgatac   5820

aacgaagtca tgcaagcctt aaacatgtca gctgcactca cagccaggaa gacaaaggaa   5880

tttagatcac cacctcaaga acagatcaat atgcttctca attttaagga tgacaaaagt   5940

gaatgtccat gtccagaaga aattcgtgac caactattgg atttccatga agatttgatg   6000

acacattgtg gaattgagct ggatgaagat gggtctctgg atggaaacag tgatttaaca   6060

attagagggc gtctgctatc cctggtagaa aaggtgacat atctgaagaa gaagcaagca   6120

gaaaaaccag ttgagagtga ctccaaaaag tcctccactc tgcagcagct gatttctgag   6180

accatggtcc gatgggctca ggagtctgtc attgaagacc ccgagctggt gagggccatg   6240

tttgtgttgc tccatcggca gtatgacggc attgggggtc ttgttcgggc cctgccaaag   6300

acctacacga taaatggtgt gtccgtggag gacaccatca acctgctggc atcccttggt   6360

cagattcggt ccctgctgag tgtgagaatg ggcaaagaag aagagaagct catgattcgt   6420

ggattagggg atattatgaa taacaaagtg ttttaccagc accctaatct catgagggca   6480

ctggggatgc acgagactgt gatggaggtc atggtgaacg tccttggagg tggagagtcc   6540

aaggaaatca cctttcccaa gatggtggcc aactgttgcc gttttctctg ttacttctgt   6600

cgtataagta ggcagaatca aaaagctatg tttgatcatc tcagttattt actggaaaac   6660

agcagtgttg gtcttgcctc cccagctatg agaggttcaa caccactgga tgtggctgca   6720

gcttcggtga tggataataa tgaactagca ttagctctgc gtgagccgga tctagaaaag   6780

gtagttcgtt atttggctgg ttgtggactg caaagttgcc agatgctggt gtctaagggc   6840

tatccagaca ttgggtggaa cccagttgaa ggagagagat atcttgactt tcttagattt   6900

gctgtcttct gtaatgggga gagtgtggag gaaaatgcaa atgtcgtggt gagattgctc   6960

attcggaggc ctgagtgttt tggtcctgct ttgagaggag aaggtgggaa tgggcttctt   7020

gcagcaatgg aagaagccat caaaatcgcc gaggatcctt cccgagatgg tccctcacca   7080

aatagcggat ccagtaaaac acttgacaca gaggaggagg aagatgacac tatccacatg   7140

gggaacgcga tcatgacctt ctattcagct ttgattgacc tcttgggacg ctgtgctcct   7200

gagatgcatt tgattcatgc cgggaaggga gaagccatca gaattaggtc cattttgaga   7260

tccctcattc ccctgggaga tttggtgggc gttatcagca tcgcttttca gatgccaaca   7320

atagccaaag atgggaatgt ggtggaacct gacatgtctg cggggttttg cccagatcac   7380

aaggcagcca tggttttatt ccttgacagg gtctatggga ttgaggttca agacttcctc   7440

ctccatcttc ttgaggttgg ctttctgcca gatctccggg cggctgcttc tttagatacg   7500

gcagctttga gtgctacaga catggccttg gccctcaatc ggtacctttg cacagccgtc   7560

ttgccattgt taacaagatg tgctcctctc tttgctggca cagagcacca cgcttctctc   7620

attgactcat tacttcatac tgtgtataga ctttctaagg gctgttcact taccaaagct   7680

cagcgggatt ccatagaagt ttgtttactc tctatttgtg gacaactgag accttctatg   7740

atgcagcact tactcagaag attagtattt gatgttccat tattaaatga acacgcaaag   7800

atgcctctta aactgctgac aaatcattat gaaagatgct ggaaatatta ctgcctgcct   7860

ggagggtggg gaaactttgg tgctgcctca gaagaagaac ttcatttatc aagaaagttg   7920

ttctggggca tttttgatgc cctgtctcaa aagaaatatg aacaagaact tttcaaactg   7980

gcactgcctt gcctgagtgc agttgcggga gctttgcctc cagactacat ggagtcaaat   8040

tatgtcagta tgatggaaaa acagtcatca atggattctg aagggaactt taacccacaa   8100

cctgttgata cctcaaatat tacaattcct gagaaattgg aatacttcat taacaaatat   8160

gcagaacact cccatgacaa atggtcaatg gacaagttgg caaatggatg gatttatgga   8220

gaaatatatt cagactcttc taaggttcag ccattaatga agccatataa gctattgtct   8280

gaaaaggaaa aagaaattta tcgctggcca atcaaagaat ctttaaaaac tatgctggct   8340

tggggctgga gaattgaaag aactcgggag ggagacagca tggcccttta caaccggact   8400

cgtcgtattt ctcagacaag ccaggtttct gtggacgctg cccatggtta cagtccccgg   8460

gccattgaca tgagcaatgt tacactatct agagacctgc atgctatggc agaaatgatg   8520

gctgaaaact accataatat atgggcaaag aaaaagaaaa tggagttgga gtccaaagga   8580

ggaggaaacc atcctctgct ggtgccctat gatacactga cagccaaaga gaaagccaag   8640

gatagagaaa aagcacagga catcctcaag ttcttgcaga tcaatggata tgctgtatcc   8700

agaggattta aggacctgga actggacacg ccttctattg agaaacgatt tgcctatagt   8760

ttcctccaac aactcattcg ctatgtggat gaagcccatc agtatatcct ggagtttgat   8820

ggtggcagca gaggcaaagg agaacatttc ccttatgaac aagaaatcaa gttctttgca   8880

aaagtcgttc ttcctttaat tgatcagtat ttcaaaaacc atcgtttata cttcttatct   8940

gcagcaagca gacctctctg ctctggagga catgcttcca acaaagagaa agaaatggtg   9000

actagcctat tctgcaaact tggagttctt gtcaggcata ggatttcact atttggcaat   9060

gatgcaacat caattgtcaa ctgtcttcat attttgggtc agactttgga tgcaaggaca   9120

gtgatgaaga ctggcctgga gagtgttaaa agtgcactca gagcttttct ggacaacgct   9180

gcagaggatc tggagaagac catggaaaac ctcaagcagg gccagttcac tcacacccga   9240

aaccagccca aaggggttac tcagattatc aattacacca cagtggccct gctgccaatg   9300

ctgtcttcat tatttgaaca tattggccag catcagttcg gagaagacct aatattggaa   9360

gatgtccagg tgtcttgtta tagaattctg actagcttat atgctttggg aaccagcaag   9420

agtatttacg tggagaggca acgttctgca ttaggagaat gtctagctgc ctttgctggt   9480

gcttttcctg tagcattttt ggaaactcat ctggacaaac ataatattta ctccatctac   9540

aataccaagt cttcacgaga aagagcagct ctcagtttgc caactaatgt ggaagatgtt   9600

tgtccaaaca taccgtcttt ggagaaactc atggaagaaa tcgtggaatt agccgagtcc   9660

ggcattcgct acactcaaat gccacatgtc atggaagtca tactgcccat gctttgcagc   9720

tacatgtctc gttggtggga gcatggacct gagaacaatc cagaacgggc cgagatgtgc   9780

tgcacagccc tgaactcaga gcacatgaac acacttctag ggaacatatt gaaaatcata   9840

tataataact tggggattga tgagggagcc tggatgaaga ggctagcagt gttttcccag   9900

cctataataa ataaagtgaa acctcagctc ttgaaaactc atttcttgcc gttaatggag   9960

aaactcaaga aaaaggcagc tacggtggtg tctgaggaag accacctgaa agctgaggcc  10020

aggggggaca tgtcggaggc agaactcctc atcctagatg agttcaccac actggccaga  10080

gatctctatg ccttctaccc tctcttgatt agatttgtgg actataacag ggcaaagtgg  10140

ctaaaggagc ctaacccaga agcagaggag ctcttccgca tggtggctga agtgtttatc  10200

tactggtcga agtcccataa tttcaaaaga gaagagcaga acttcgttgt acagaatgaa  10260

atcaacaata tgtctttcct tattactgat accaagtcaa agatgtcaaa ggcagctgtt  10320

tctgatcagg aaaggaagaa aatgaagcgc aaaggagatc ggtattccat gcagacctct  10380

ctgattgtag cagctctgaa gcggttactg cccattgggt tgaacatctg tgcccctggg  10440

gaccaggagc tcattgctct ggccaaaaat cgatttagcc tgaaagatac cgaggatgaa  10500

gtacgagata taatccgcag caatattcat ttacaaggca agttggagga tcctgctatt  10560

agatggcaaa tggctcttta caaagactta ccaaacagga ctgatgatac ctcagatcca  10620

gagaagacgg tagaaagagt attggatata gcaaatgtgc tttttcatct tgaacagaag  10680

tctaaacgtg tgggtcggag acattactgt ctcaggtgga acatcctcag agatctaaaa  10740

aggctgtatg gcataaacta ctgtccaagc agaggaaaag ggctgttgta gcctgcttcc  10800

ggatggcccc cttatataat ctgccaaggc atcgggctgt caatctcttt cttcagggat  10860

atgaaaagtc ttggattgaa acagaagaac attactttga agataaactg atagaagatt  10920

tagcaaaacc tggggctgaa cctccagaag aagatgaagg cactaagaga gttgatcctc  10980

tacatcagct gatccttctg tttagtcgga cagctttaac agagaaatgc aaactggagg  11040

aagatttttt atatatggcc tatgcagata ttatggcaaa gagttgtcat gatgaggaag  11100

atgacgatgg tgaagaggaa gtgaagagtt ttgaagaaaa agaaatggaa aagcaaaagc  11160

ttctatacca gcaagcccga ctccacgatc gtggcgcggc tgagatggtg ctacagacaa  11220

tcagtgccag caaaggtgaa actggaccaa tggtagcagc tactctgaaa cttggaattg  11280

ctattttaaa tggtgggaac tccacagtac agcagaaaat gcttgactac ctcaaggaga  11340

aaaaggatgt gggcttcttt cagagcctgg ccggcctgat gcagtcatgt agtgtccttg  11400

acctaaatgc atttgagcga caaaacaaag ctgaaggtct tgggatggtg acagaggaag  11460

gatcaggaga aaaggttctg caggacgatg agttcacctg tgacctcttc cgattcctgc  11520

aactactctg tgagggacac aactcagatt ttcagaatta tctgagaact cagactggca  11580

ataatacaac tgtcaacata attatctcca ctgtagacta cctactgaga gttcaggaat  11640

caattagtga cttttattgg tattactctg ggaaagatgt tattgatgaa caaggacaac  11700

ggaatttctc caaagctatc caagtggcaa aacaagtctt taacactctt acagagtata  11760

ttcagggtcc ttgcactggg aatcaacaga gtttggcaca cagcaggctg tgggatgctg  11820

tggtcggctt tcttcatgtg tttgcccata tgcagatgaa gctgtcgcag gattccagtc  11880

aaattgagct attaaaagaa ttaatggatc tgcagaagga tatggtggtc atgttgctgt  11940

ccatgttaga aggtaatgtt gttaatggaa cgattggcaa acagatggtg gatatgcttg  12000

tggaatcttc caacaacgtg gagatgattc tcaaattttt tgacatgttc ttaaaactaa  12060

aggatttgac gtcgtctgat acttttaaag aatatgaccc cgatggcaag ggagtcattt  12120

ccaagaggga cttccacaaa gcgatggaga gccataagca ctacacgcag tcagaaacgg  12180

aatttctttt gtcttgtgcg gagacggatg agaatgaaac cctcgactac gaagagttcg  12240

tcaaacgctt ccacgaacct gcgaaggaca tcggcttcaa cgtcgccgtc cttctgacaa  12300

acctctctga gcacatgccc aacgataccc gacttcagac ttttctggaa ttagcagaga  12360

gcgtcctgaa ttatttccag ccctttctgg gccgcatcga aatcatggga agcgccaaac  12420

gcatcgagag ggtctatttt gaaatcagtg agtccagccg aacccagtgg gagaagcccc  12480

aggtcaagga gtccaaaaga cagttcatat ttgacgtggt caacgaaggc ggagagaaag  12540

agaagatgga actctttgtg aacttctgcg aggacaccat ctttgaaatg cagctggcgg  12600

ctcagatctc ggagtcggac ttgaacgaga ggtcagcgaa taaggaagaa agcgagaagg  12660

agaggccgga agagcagggg ccgaggatgg ctttcttctc cattctgacg gtcaggtcgg  12720

ccctgtttgc gctcaggtac aatatcttga cccttatgcg aatgctcagt ctgaagagcc  12780

tgaagaagca gatgaaaaaa gtaaaaaaga tgaccgtgaa ggacatggtc acggccttct  12840

tttcatccta ctggagtatt ttcatgaccc tcttgcactt cgtggccagc gttttcagag  12900

gctttttccg catcatttgc agcctgctgc ttgggggaag cctcgtcgaa ggtgctaaaa  12960

agatcaaagt tgcagaactg ttagccaaca tgccagaccc cactcaggat gaggttagag  13020

gagatgggga ggagggagag aggaaacccc tggaagccgc cctgccctcc gaggatctga  13080

ccgacttaaa ggagctgaca gaggaaagtg accttctttc ggacatcttt ggcctggatc  13140

tgaagagaga aggaggacag tacaaactga ttcctcataa tccaaatgct gggctcagtg  13200

acctcatgag caacccagtc cccatgcctg aggtgcagga aaaatttcag gaacagaagg  13260

caaaagaaga agaaaaggaa gaaaaagaag aaaccaaatc tgaacctgaa aaagccgagg  13320

gagaagatgg agaaaaagaa gagaaagcca aggaagacaa gggcaaacaa aagttgaggc  13380

agcttcacac acacagatac ggagaaccag aagtgccaga gtcagcattc tggaagaaaa  13440

tcatagcata tcaacagaaa cttctaaact attttgctcg caacttttac aacatgagaa  13500

tgttagcctt atttgtcgca tttgctatca atttcatctt gctcttttat aaggtctcca  13560

cttcttctgt ggttgaagga aaggagctcc ccacgagaag ttcaagtgaa aatgccaaag  13620

tgacaagcct ggacagcagc tcccatagaa tcatcgcagt tcactatgta ctagaggaga  13680

gcagcggcta catggagccc acgttgcgta tcttagctat tctgcacacg gtcatttctt  13740

tcttctgcat cattggatac tactgcttga aagtcccatt ggttattttt aagcgagaaa  13800

aggaagtggc acggaaattg gaatttgatg ggctttatat tacagaacag ccttcagaag  13860

atgatattaa aggccagtgg gatagactcg taatcaacac acagtcattt cccaacaact  13920

actgggacaa atttgttaaa agaaaggtta tggataaata tggagagttc tacggccgag  13980

acagaatcag tgaattactt ggcatggaca aggcagctct ggacttcagt gatgccagag  14040

aaaagaagaa gccaaagaaa gacagctcct tatcagctgt actgaactcc attgatgtga  14100

agtatcagat gtggaaacta ggagtcgttt tcactgacaa ctccttcctc tacctagcct  14160

ggtatatgac tatgtctgtt cttggacact ataacaactt tttttttgcc gctcaccttc  14220

tcgacattgc tatgggattc aagacattaa gaaccatctt gtcctcagta actcacaatg  14280

gcaaacagct cgtattaacc gttggcttat tagctgttgt tgtataccta tacactgtgg  14340

tggcattcaa ttttttccga aaattctaca ataaaagtga agatggtgat acaccagata  14400

tgaaatgtga cgatatgcta acatgctata tgttccacat gtatgttgga gttcgtgctg  14460

gaggagggat cggggatgaa atcgaagacc cagcaggaga tgaatatgag atctatcgaa  14520

tcatctttga catcactttc ttcttctttg ttattgtcat tctcttggcc ataatacaag  14580

gtctaattat tgatgctttt ggagaactaa gagaccaaca ggaacaagtc aaagaagaca  14640

tggagaccaa atgcttcatc tgtgggatag gcaatgatta cttcgacaca gtgccacatg  14700

gctttgaaac ccacacttta caggagcaca acttggctaa ttacttgttt tttctgatgt  14760

atcttataaa caaagatgaa acagaacaca caggacagga atcttatgtc tggaagatgt  14820

atcaagaaag gtgttgggaa tttttcccag caggggattg cttccggaaa cagtatgaag  14880

accagctaaa ttaaactcag acccaatcac ctctaaaaac caaaacccta cccctctctc  14940

tccctctctc aatttctctg ctctcttgga aacattttgc tgattttgtg aattgccagc  15000

gttgtgtgtt ttctgggagc atcgaagctc tgtttcggaa gagctgtttc ctccccccac  15060

cttttgtatt tactttgaga ctaaagactg aagaataatc taaattcata ctcagacaaa  15120

aaaaggaatt ctggaaagaa aaccattctg gacactgtca taacacacat agatagattt  15180

tcttctgaga ctcccggagt cttctcgagc tacgagacct tcacagagac acgtggcagc  15240

cacactcacc cagcctcttt atttcaccat cctggaagga aactgtctgt ctaatggtca  15300

cagagcactg tagcacttaa cagattgcca tggacaccag ttgcgaaggg aaatagtgcc  15360

ttactatatg tgggttgagc tatgcagaag atacgtgcat gaaaaaacat ctttattttc  15420

tttatgtcga cctttctttt cttagattga ttttgtgagg tttttttttt ttcctttagt  15480

cttttcttta gtgggggagg gtaagaaaag cagtttgcac ttaaaaagaa aaaaaaaaaa  15540

cgggtggtgt gtctcaggac aaaaggaggc tcttctcatt cagctaaatt cacatttgcc  15600

cccccccccc gcccccgccc ccatatgctc ctgctattat tttggtaatg ctctgatgca  15660

acattgcaac tttatgaaat ctttgtatga aaacaaaaag actgcaaaaa atacactttc  15720

aaaagaaacc attcattgca tgtttattat gcaagtttaa atgaacaaag aaaaccttca  15780

gaaacaagtt gatcaacgtg agagaaattt catgataatt attcatagta ataaagtgtc  15840

gtgggcttaa ttgtatatct ggagccagtg tcatccacca acaatgtgat acaatatgaa  15900

cttgacagta gttttgggtt ttgctcattc tttcagccac ctgtgatcag ttttgttgat  15960

taaggacttc ttgtcaggcc attttttaat atcaaagctg aagcaatatc cattcaggga  16020

tttcatcagt tgcatcacaa aacacggatg ataatataca tcactccatt ttttccattt  16080

tgagtccttt taaatgtaat gctaaccttt acaattaaaa agtcagattc agaatggaaa  16140

caaggtcatt ttgcaaacat tggagctctt ttattacaag tctgcttgtt aattttagaa  16200

ctgtaaaacc gctctgatta aactatttaa ctaac                             16235


<210>  1397
<211>  3556
<212>  PRT
<213>  Homo sapiens

<400>  1397


Met Ala Asp Gly Gly Glu Gly Glu Asp Glu Ile Gln Phe Leu Arg Thr 
1               5                   10                  15      


Glu Asn Val Pro Pro Asp Leu Ser Ile Cys Thr Phe Val Leu Glu Gln 
            20                  25                  30          


Ser Leu Ser Val Arg Ala Leu Gln Glu Met Leu Ala Asn Thr Val Glu 
        35                  40                  45              


Lys Ser Glu Gly Ala Ile Asp Val Glu Lys Trp Thr Ala Gln Gly Gly 
    50                  55                  60                  


Gly His Arg Thr Leu Leu Tyr Gly His Ala Ile Leu Leu Arg His Ser 
65                  70                  75                  80  


Tyr Ser Gly Met Tyr Leu Cys Cys Leu Ser Thr Ser Arg Ser Ser Thr 
                85                  90                  95      


Asp Lys Leu Ala Phe Asp Val Gly Leu Gln Glu Asp Thr Thr Gly Glu 
            100                 105                 110         


Ala Cys Trp Trp Thr Ile His Pro Ala Ser Lys Gln Arg Ser Glu Gly 
        115                 120                 125             


Glu Lys Val Arg Val Gly Asp Asp Leu Ile Leu Val Ser Val Ser Ser 
    130                 135                 140                 


Glu Arg Tyr Leu His Leu Ser Tyr Gly Asn Gly Ser Leu His Val Asp 
145                 150                 155                 160 


Ala Ala Phe Gln Gln Thr Leu Trp Ser Val Ala Pro Ile Ser Ser Gly 
                165                 170                 175     


Ser Glu Ala Ala Gln Gly Tyr Leu Ile Gly Gly Asp Val Leu Arg Leu 
            180                 185                 190         


Leu His Gly His Met Asp Glu Cys Leu Thr Val Pro Ser Gly Glu His 
        195                 200                 205             


Gly Glu Glu Gln Arg Arg Thr Val His Tyr Glu Gly Gly Ala Val Ser 
    210                 215                 220                 


Val His Ala Arg Ser Leu Trp Arg Leu Glu Thr Leu Arg Val Ala Trp 
225                 230                 235                 240 


Ser Gly Ser His Ile Arg Trp Gly Gln Pro Phe Arg Leu Arg His Val 
                245                 250                 255     


Thr Thr Gly Lys Tyr Leu Ser Leu Met Glu Asp Lys Asn Leu Leu Leu 
            260                 265                 270         


Met Asp Lys Glu Lys Ala Asp Val Lys Ser Thr Ala Phe Thr Phe Arg 
        275                 280                 285             


Ser Ser Lys Glu Lys Leu Asp Val Gly Val Arg Lys Glu Val Asp Gly 
    290                 295                 300                 


Met Gly Thr Ser Glu Ile Lys Tyr Gly Asp Ser Val Cys Tyr Ile Gln 
305                 310                 315                 320 


His Val Asp Thr Gly Leu Trp Leu Thr Tyr Gln Ser Val Asp Val Lys 
                325                 330                 335     


Ser Val Arg Met Gly Ser Ile Gln Arg Lys Ala Ile Met His His Glu 
            340                 345                 350         


Gly His Met Asp Asp Gly Ile Ser Leu Ser Arg Ser Gln His Glu Glu 
        355                 360                 365             


Ser Arg Thr Ala Arg Val Ile Arg Ser Thr Val Phe Leu Phe Asn Arg 
    370                 375                 380                 


Phe Ile Arg Gly Leu Asp Ala Leu Ser Lys Lys Ala Lys Ala Ser Thr 
385                 390                 395                 400 


Val Asp Leu Pro Ile Glu Ser Val Ser Leu Ser Leu Gln Asp Leu Ile 
                405                 410                 415     


Gly Tyr Phe His Pro Pro Asp Glu His Leu Glu His Glu Asp Lys Gln 
            420                 425                 430         


Asn Arg Leu Arg Ala Leu Lys Asn Arg Gln Asn Leu Phe Gln Glu Glu 
        435                 440                 445             


Gly Met Ile Asn Leu Val Leu Glu Cys Ile Asp Arg Leu His Val Tyr 
    450                 455                 460                 


Ser Ser Ala Ala His Phe Ala Asp Val Ala Gly Arg Glu Ala Gly Glu 
465                 470                 475                 480 


Ser Trp Lys Ser Ile Leu Asn Ser Leu Tyr Glu Leu Leu Ala Ala Leu 
                485                 490                 495     


Ile Arg Gly Asn Arg Lys Asn Cys Ala Gln Phe Ser Gly Ser Leu Asp 
            500                 505                 510         


Trp Leu Ile Ser Arg Leu Glu Arg Leu Glu Ala Ser Ser Gly Ile Leu 
        515                 520                 525             


Glu Val Leu His Cys Val Leu Val Glu Ser Pro Glu Ala Leu Asn Ile 
    530                 535                 540                 


Ile Lys Glu Gly His Ile Lys Ser Ile Ile Ser Leu Leu Asp Lys His 
545                 550                 555                 560 


Gly Arg Asn His Lys Val Leu Asp Val Leu Cys Ser Leu Cys Val Cys 
                565                 570                 575     


His Gly Val Ala Val Arg Ser Asn Gln His Leu Ile Cys Asp Asn Leu 
            580                 585                 590         


Leu Pro Gly Arg Asp Leu Leu Leu Gln Thr Arg Leu Val Asn His Val 
        595                 600                 605             


Ser Ser Met Arg Pro Asn Ile Phe Leu Gly Val Ser Glu Gly Ser Ala 
    610                 615                 620                 


Gln Tyr Lys Lys Trp Tyr Tyr Glu Leu Met Val Asp His Thr Glu Pro 
625                 630                 635                 640 


Phe Val Thr Ala Glu Ala Thr His Leu Arg Val Gly Trp Ala Ser Thr 
                645                 650                 655     


Glu Gly Tyr Ser Pro Tyr Pro Gly Gly Gly Glu Glu Trp Gly Gly Asn 
            660                 665                 670         


Gly Val Gly Asp Asp Leu Phe Ser Tyr Gly Phe Asp Gly Leu His Leu 
        675                 680                 685             


Trp Ser Gly Cys Ile Ala Arg Thr Val Ser Ser Pro Asn Gln His Leu 
    690                 695                 700                 


Leu Arg Thr Asp Asp Val Ile Ser Cys Cys Leu Asp Leu Ser Ala Pro 
705                 710                 715                 720 


Ser Ile Ser Phe Arg Ile Asn Gly Gln Pro Val Gln Gly Met Phe Glu 
                725                 730                 735     


Asn Phe Asn Ile Asp Gly Leu Phe Phe Pro Val Val Ser Phe Ser Ala 
            740                 745                 750         


Gly Ile Lys Val Arg Phe Leu Leu Gly Gly Arg His Gly Glu Phe Lys 
        755                 760                 765             


Phe Leu Pro Pro Pro Gly Tyr Ala Pro Cys Tyr Glu Ala Val Leu Pro 
    770                 775                 780                 


Lys Glu Lys Leu Lys Val Glu His Ser Arg Glu Tyr Lys Gln Glu Arg 
785                 790                 795                 800 


Thr Tyr Thr Arg Asp Leu Leu Gly Pro Thr Val Ser Leu Thr Gln Ala 
                805                 810                 815     


Ala Phe Thr Pro Ile Pro Val Asp Thr Ser Gln Ile Val Leu Pro Pro 
            820                 825                 830         


His Leu Glu Arg Ile Arg Glu Lys Leu Ala Glu Asn Ile His Glu Leu 
        835                 840                 845             


Trp Val Met Asn Lys Ile Glu Leu Gly Trp Gln Tyr Gly Pro Val Arg 
    850                 855                 860                 


Asp Asp Asn Lys Arg Gln His Pro Cys Leu Val Glu Phe Ser Lys Leu 
865                 870                 875                 880 


Pro Glu Gln Glu Arg Asn Tyr Asn Leu Gln Met Ser Leu Glu Thr Leu 
                885                 890                 895     


Lys Thr Leu Leu Ala Leu Gly Cys His Val Gly Ile Ser Asp Glu His 
            900                 905                 910         


Ala Glu Asp Lys Val Lys Lys Met Lys Leu Pro Lys Asn Tyr Gln Leu 
        915                 920                 925             


Thr Ser Gly Tyr Lys Pro Ala Pro Met Asp Leu Ser Phe Ile Lys Leu 
    930                 935                 940                 


Thr Pro Ser Gln Glu Ala Met Val Asp Lys Leu Ala Glu Asn Ala His 
945                 950                 955                 960 


Asn Val Trp Ala Arg Asp Arg Ile Arg Gln Gly Trp Thr Tyr Gly Ile 
                965                 970                 975     


Gln Gln Asp Val Lys Asn Arg Arg Asn Pro Arg Leu Val Pro Tyr Thr 
            980                 985                 990         


Leu Leu Asp Asp Arg Thr Lys Lys  Ser Asn Lys Asp Ser  Leu Arg Glu 
        995                 1000                 1005             


Ala Val  Arg Thr Leu Leu Gly  Tyr Gly Tyr Asn Leu  Glu Ala Pro 
    1010                 1015                 1020             


Asp Gln  Asp His Ala Ala Arg  Ala Glu Val Cys Ser  Gly Thr Gly 
    1025                 1030                 1035             


Glu Arg  Phe Arg Ile Phe Arg  Ala Glu Lys Thr Tyr  Ala Val Lys 
    1040                 1045                 1050             


Ala Gly  Arg Trp Tyr Phe Glu  Phe Glu Thr Val Thr  Ala Gly Asp 
    1055                 1060                 1065             


Met Arg  Val Gly Trp Ser Arg  Pro Gly Cys Gln Pro  Asp Gln Glu 
    1070                 1075                 1080             


Leu Gly  Ser Asp Glu Arg Ala  Phe Ala Phe Asp Gly  Phe Lys Ala 
    1085                 1090                 1095             


Gln Arg  Trp His Gln Gly Asn  Glu His Tyr Gly Arg  Ser Trp Gln 
    1100                 1105                 1110             


Ala Gly  Asp Val Val Gly Cys  Met Val Asp Met Asn  Glu His Thr 
    1115                 1120                 1125             


Met Met  Phe Thr Leu Asn Gly  Glu Ile Leu Leu Asp  Asp Ser Gly 
    1130                 1135                 1140             


Ser Glu  Leu Ala Phe Lys Asp  Phe Asp Val Gly Asp  Gly Phe Ile 
    1145                 1150                 1155             


Pro Val  Cys Ser Leu Gly Val  Ala Gln Val Gly Arg  Met Asn Phe 
    1160                 1165                 1170             


Gly Lys  Asp Val Ser Thr Leu  Lys Tyr Phe Thr Ile  Cys Gly Leu 
    1175                 1180                 1185             


Gln Glu  Gly Tyr Glu Pro Phe  Ala Val Asn Thr Asn  Arg Asp Ile 
    1190                 1195                 1200             


Thr Met  Trp Leu Ser Lys Arg  Leu Pro Gln Phe Leu  Gln Val Pro 
    1205                 1210                 1215             


Ser Asn  His Glu His Ile Glu  Val Thr Arg Ile Asp  Gly Thr Ile 
    1220                 1225                 1230             


Asp Ser  Ser Pro Cys Leu Lys  Val Thr Gln Lys Ser  Phe Gly Ser 
    1235                 1240                 1245             


Gln Asn  Ser Asn Thr Asp Ile  Met Phe Tyr Arg Leu  Ser Met Pro 
    1250                 1255                 1260             


Ile Glu  Cys Ala Glu Val Phe  Ser Lys Thr Val Ala  Gly Gly Leu 
    1265                 1270                 1275             


Pro Gly  Ala Gly Leu Phe Gly  Pro Lys Asn Asp Leu  Glu Asp Tyr 
    1280                 1285                 1290             


Asp Ala  Asp Ser Asp Phe Glu  Val Leu Met Lys Thr  Ala His Gly 
    1295                 1300                 1305             


His Leu  Val Pro Asp Arg Val  Asp Lys Asp Lys Glu  Ala Thr Lys 
    1310                 1315                 1320             


Pro Glu  Phe Asn Asn His Lys  Asp Tyr Ala Gln Glu  Lys Pro Ser 
    1325                 1330                 1335             


Arg Leu  Lys Gln Arg Phe Leu  Leu Arg Arg Thr Lys  Pro Asp Tyr 
    1340                 1345                 1350             


Ser Thr  Ser His Ser Ala Arg  Leu Thr Glu Asp Val  Leu Ala Asp 
    1355                 1360                 1365             


Asp Arg  Asp Asp Tyr Asp Phe  Leu Met Gln Thr Ser  Thr Tyr Tyr 
    1370                 1375                 1380             


Tyr Ser  Val Arg Ile Phe Pro  Gly Gln Glu Pro Ala  Asn Val Trp 
    1385                 1390                 1395             


Val Gly  Trp Ile Thr Ser Asp  Phe His Gln Tyr Asp  Thr Gly Phe 
    1400                 1405                 1410             


Asp Leu  Asp Arg Val Arg Thr  Val Thr Val Thr Leu  Gly Asp Glu 
    1415                 1420                 1425             


Lys Gly  Lys Val His Glu Ser  Ile Lys Arg Ser Asn  Cys Tyr Met 
    1430                 1435                 1440             


Val Cys  Ala Gly Glu Ser Met  Ser Pro Gly Gln Gly  Arg Asn Asn 
    1445                 1450                 1455             


Asn Gly  Leu Glu Ile Gly Cys  Val Val Asp Ala Ala  Ser Gly Leu 
    1460                 1465                 1470             


Leu Thr  Phe Ile Ala Asn Gly  Lys Glu Leu Ser Thr  Tyr Tyr Gln 
    1475                 1480                 1485             


Val Glu  Pro Ser Thr Lys Leu  Phe Pro Ala Val Phe  Ala Gln Ala 
    1490                 1495                 1500             


Thr Ser  Pro Asn Val Phe Gln  Phe Glu Leu Gly Arg  Ile Lys Asn 
    1505                 1510                 1515             


Val Met  Pro Leu Ser Ala Gly  Leu Phe Lys Ser Glu  His Lys Asn 
    1520                 1525                 1530             


Pro Val  Pro Gln Cys Pro Pro  Arg Leu His Val Gln  Phe Leu Ser 
    1535                 1540                 1545             


His Val  Leu Trp Ser Arg Met  Pro Asn Gln Phe Leu  Lys Val Asp 
    1550                 1555                 1560             


Val Ser  Arg Ile Ser Glu Arg  Gln Gly Trp Leu Val  Gln Cys Leu 
    1565                 1570                 1575             


Asp Pro  Leu Gln Phe Met Ser  Leu His Ile Pro Glu  Glu Asn Arg 
    1580                 1585                 1590             


Ser Val  Asp Ile Leu Glu Leu  Thr Glu Gln Glu Glu  Leu Leu Lys 
    1595                 1600                 1605             


Phe His  Tyr His Thr Leu Arg  Leu Tyr Ser Ala Val  Cys Ala Leu 
    1610                 1615                 1620             


Gly Asn  His Arg Val Ala His  Ala Leu Cys Ser His  Val Asp Glu 
    1625                 1630                 1635             


Pro Gln  Leu Leu Tyr Ala Ile  Glu Asn Lys Tyr Met  Pro Gly Leu 
    1640                 1645                 1650             


Leu Arg  Ala Gly Tyr Tyr Asp  Leu Leu Ile Asp Ile  His Leu Ser 
    1655                 1660                 1665             


Ser Tyr  Ala Thr Ala Arg Leu  Met Met Asn Asn Glu  Tyr Ile Val 
    1670                 1675                 1680             


Pro Met  Thr Glu Glu Thr Lys  Ser Ile Thr Leu Phe  Pro Asp Glu 
    1685                 1690                 1695             


Asn Lys  Lys His Gly Leu Pro  Gly Ile Gly Leu Ser  Thr Ser Leu 
    1700                 1705                 1710             


Arg Pro  Arg Met Gln Phe Ser  Ser Pro Ser Phe Val  Ser Ile Ser 
    1715                 1720                 1725             


Asn Glu  Cys Tyr Gln Tyr Ser  Pro Glu Phe Pro Leu  Asp Ile Leu 
    1730                 1735                 1740             


Lys Ser  Lys Thr Ile Gln Met  Leu Thr Glu Ala Val  Lys Glu Gly 
    1745                 1750                 1755             


Ser Leu  His Ala Arg Asp Pro  Val Gly Gly Thr Thr  Glu Phe Leu 
    1760                 1765                 1770             


Phe Val  Pro Leu Ile Lys Leu  Phe Tyr Thr Leu Leu  Ile Met Gly 
    1775                 1780                 1785             


Ile Phe  His Asn Glu Asp Leu  Lys His Ile Leu Gln  Leu Ile Glu 
    1790                 1795                 1800             


Pro Ser  Val Phe Lys Glu Ala  Ala Thr Pro Glu Glu  Glu Ser Asp 
    1805                 1810                 1815             


Thr Leu  Glu Lys Glu Leu Ser  Val Asp Asp Ala Lys  Leu Gln Gly 
    1820                 1825                 1830             


Ala Gly  Glu Glu Glu Ala Lys  Gly Gly Lys Arg Pro  Lys Glu Gly 
    1835                 1840                 1845             


Leu Leu  Gln Met Lys Leu Pro  Glu Pro Val Lys Leu  Gln Met Cys 
    1850                 1855                 1860             


Leu Leu  Leu Gln Tyr Leu Cys  Asp Cys Gln Val Arg  His Arg Ile 
    1865                 1870                 1875             


Glu Ala  Ile Val Ala Phe Ser  Asp Asp Phe Val Ala  Lys Leu Gln 
    1880                 1885                 1890             


Asp Asn  Gln Arg Phe Arg Tyr  Asn Glu Val Met Gln  Ala Leu Asn 
    1895                 1900                 1905             


Met Ser  Ala Ala Leu Thr Ala  Arg Lys Thr Lys Glu  Phe Arg Ser 
    1910                 1915                 1920             


Pro Pro  Gln Glu Gln Ile Asn  Met Leu Leu Asn Phe  Lys Asp Asp 
    1925                 1930                 1935             


Lys Ser  Glu Cys Pro Cys Pro  Glu Glu Ile Arg Asp  Gln Leu Leu 
    1940                 1945                 1950             


Asp Phe  His Glu Asp Leu Met  Thr His Cys Gly Ile  Glu Leu Asp 
    1955                 1960                 1965             


Glu Asp  Gly Ser Leu Asp Gly  Asn Ser Asp Leu Thr  Ile Arg Gly 
    1970                 1975                 1980             


Arg Leu  Leu Ser Leu Val Glu  Lys Val Thr Tyr Leu  Lys Lys Lys 
    1985                 1990                 1995             


Gln Ala  Glu Lys Pro Val Glu  Ser Asp Ser Lys Lys  Ser Ser Thr 
    2000                 2005                 2010             


Leu Gln  Gln Leu Ile Ser Glu  Thr Met Val Arg Trp  Ala Gln Glu 
    2015                 2020                 2025             


Ser Val  Ile Glu Asp Pro Glu  Leu Val Arg Ala Met  Phe Val Leu 
    2030                 2035                 2040             


Leu His  Arg Gln Tyr Asp Gly  Ile Gly Gly Leu Val  Arg Ala Leu 
    2045                 2050                 2055             


Pro Lys  Thr Tyr Thr Ile Asn  Gly Val Ser Val Glu  Asp Thr Ile 
    2060                 2065                 2070             


Asn Leu  Leu Ala Ser Leu Gly  Gln Ile Arg Ser Leu  Leu Ser Val 
    2075                 2080                 2085             


Arg Met  Gly Lys Glu Glu Glu  Lys Leu Met Ile Arg  Gly Leu Gly 
    2090                 2095                 2100             


Asp Ile  Met Asn Asn Lys Val  Phe Tyr Gln His Pro  Asn Leu Met 
    2105                 2110                 2115             


Arg Ala  Leu Gly Met His Glu  Thr Val Met Glu Val  Met Val Asn 
    2120                 2125                 2130             


Val Leu  Gly Gly Gly Glu Ser  Lys Glu Ile Thr Phe  Pro Lys Met 
    2135                 2140                 2145             


Val Ala  Asn Cys Cys Arg Phe  Leu Cys Tyr Phe Cys  Arg Ile Ser 
    2150                 2155                 2160             


Arg Gln  Asn Gln Lys Ala Met  Phe Asp His Leu Ser  Tyr Leu Leu 
    2165                 2170                 2175             


Glu Asn  Ser Ser Val Gly Leu  Ala Ser Pro Ala Met  Arg Gly Ser 
    2180                 2185                 2190             


Thr Pro  Leu Asp Val Ala Ala  Ala Ser Val Met Asp  Asn Asn Glu 
    2195                 2200                 2205             


Leu Ala  Leu Ala Leu Arg Glu  Pro Asp Leu Glu Lys  Val Val Arg 
    2210                 2215                 2220             


Tyr Leu  Ala Gly Cys Gly Leu  Gln Ser Cys Gln Met  Leu Val Ser 
    2225                 2230                 2235             


Lys Gly  Tyr Pro Asp Ile Gly  Trp Asn Pro Val Glu  Gly Glu Arg 
    2240                 2245                 2250             


Tyr Leu  Asp Phe Leu Arg Phe  Ala Val Phe Cys Asn  Gly Glu Ser 
    2255                 2260                 2265             


Val Glu  Glu Asn Ala Asn Val  Val Val Arg Leu Leu  Ile Arg Arg 
    2270                 2275                 2280             


Pro Glu  Cys Phe Gly Pro Ala  Leu Arg Gly Glu Gly  Gly Asn Gly 
    2285                 2290                 2295             


Leu Leu  Ala Ala Met Glu Glu  Ala Ile Lys Ile Ala  Glu Asp Pro 
    2300                 2305                 2310             


Ser Arg  Asp Gly Pro Ser Pro  Asn Ser Gly Ser Ser  Lys Thr Leu 
    2315                 2320                 2325             


Asp Thr  Glu Glu Glu Glu Asp  Asp Thr Ile His Met  Gly Asn Ala 
    2330                 2335                 2340             


Ile Met  Thr Phe Tyr Ser Ala  Leu Ile Asp Leu Leu  Gly Arg Cys 
    2345                 2350                 2355             


Ala Pro  Glu Met His Leu Ile  His Ala Gly Lys Gly  Glu Ala Ile 
    2360                 2365                 2370             


Arg Ile  Arg Ser Ile Leu Arg  Ser Leu Ile Pro Leu  Gly Asp Leu 
    2375                 2380                 2385             


Val Gly  Val Ile Ser Ile Ala  Phe Gln Met Pro Thr  Ile Ala Lys 
    2390                 2395                 2400             


Asp Gly  Asn Val Val Glu Pro  Asp Met Ser Ala Gly  Phe Cys Pro 
    2405                 2410                 2415             


Asp His  Lys Ala Ala Met Val  Leu Phe Leu Asp Arg  Val Tyr Gly 
    2420                 2425                 2430             


Ile Glu  Val Gln Asp Phe Leu  Leu His Leu Leu Glu  Val Gly Phe 
    2435                 2440                 2445             


Leu Pro  Asp Leu Arg Ala Ala  Ala Ser Leu Asp Thr  Ala Ala Leu 
    2450                 2455                 2460             


Ser Ala  Thr Asp Met Ala Leu  Ala Leu Asn Arg Tyr  Leu Cys Thr 
    2465                 2470                 2475             


Ala Val  Leu Pro Leu Leu Thr  Arg Cys Ala Pro Leu  Phe Ala Gly 
    2480                 2485                 2490             


Thr Glu  His His Ala Ser Leu  Ile Asp Ser Leu Leu  His Thr Val 
    2495                 2500                 2505             


Tyr Arg  Leu Ser Lys Gly Cys  Ser Leu Thr Lys Ala  Gln Arg Asp 
    2510                 2515                 2520             


Ser Ile  Glu Val Cys Leu Leu  Ser Ile Cys Gly Gln  Leu Arg Pro 
    2525                 2530                 2535             


Ser Met  Met Gln His Leu Leu  Arg Arg Leu Val Phe  Asp Val Pro 
    2540                 2545                 2550             


Leu Leu  Asn Glu His Ala Lys  Met Pro Leu Lys Leu  Leu Thr Asn 
    2555                 2560                 2565             


His Tyr  Glu Arg Cys Trp Lys  Tyr Tyr Cys Leu Pro  Gly Gly Trp 
    2570                 2575                 2580             


Gly Asn  Phe Gly Ala Ala Ser  Glu Glu Glu Leu His  Leu Ser Arg 
    2585                 2590                 2595             


Lys Leu  Phe Trp Gly Ile Phe  Asp Ala Leu Ser Gln  Lys Lys Tyr 
    2600                 2605                 2610             


Glu Gln  Glu Leu Phe Lys Leu  Ala Leu Pro Cys Leu  Ser Ala Val 
    2615                 2620                 2625             


Ala Gly  Ala Leu Pro Pro Asp  Tyr Met Glu Ser Asn  Tyr Val Ser 
    2630                 2635                 2640             


Met Met  Glu Lys Gln Ser Ser  Met Asp Ser Glu Gly  Asn Phe Asn 
    2645                 2650                 2655             


Pro Gln  Pro Val Asp Thr Ser  Asn Ile Thr Ile Pro  Glu Lys Leu 
    2660                 2665                 2670             


Glu Tyr  Phe Ile Asn Lys Tyr  Ala Glu His Ser His  Asp Lys Trp 
    2675                 2680                 2685             


Ser Met  Asp Lys Leu Ala Asn  Gly Trp Ile Tyr Gly  Glu Ile Tyr 
    2690                 2695                 2700             


Ser Asp  Ser Ser Lys Val Gln  Pro Leu Met Lys Pro  Tyr Lys Leu 
    2705                 2710                 2715             


Leu Ser  Glu Lys Glu Lys Glu  Ile Tyr Arg Trp Pro  Ile Lys Glu 
    2720                 2725                 2730             


Ser Leu  Lys Thr Met Leu Ala  Trp Gly Trp Arg Ile  Glu Arg Thr 
    2735                 2740                 2745             


Arg Glu  Gly Asp Ser Met Ala  Leu Tyr Asn Arg Thr  Arg Arg Ile 
    2750                 2755                 2760             


Ser Gln  Thr Ser Gln Val Ser  Val Asp Ala Ala His  Gly Tyr Ser 
    2765                 2770                 2775             


Pro Arg  Ala Ile Asp Met Ser  Asn Val Thr Leu Ser  Arg Asp Leu 
    2780                 2785                 2790             


His Ala  Met Ala Glu Met Met  Ala Glu Asn Tyr His  Asn Ile Trp 
    2795                 2800                 2805             


Ala Lys  Lys Lys Lys Met Glu  Leu Glu Ser Lys Gly  Gly Gly Asn 
    2810                 2815                 2820             


His Pro  Leu Leu Val Pro Tyr  Asp Thr Leu Thr Ala  Lys Glu Lys 
    2825                 2830                 2835             


Ala Lys  Asp Arg Glu Lys Ala  Gln Asp Ile Leu Lys  Phe Leu Gln 
    2840                 2845                 2850             


Ile Asn  Gly Tyr Ala Val Ser  Arg Gly Phe Lys Asp  Leu Glu Leu 
    2855                 2860                 2865             


Asp Thr  Pro Ser Ile Glu Lys  Arg Phe Ala Tyr Ser  Phe Leu Gln 
    2870                 2875                 2880             


Gln Leu  Ile Arg Tyr Val Asp  Glu Ala His Gln Tyr  Ile Leu Glu 
    2885                 2890                 2895             


Phe Asp  Gly Gly Ser Arg Gly  Lys Gly Glu His Phe  Pro Tyr Glu 
    2900                 2905                 2910             


Gln Glu  Ile Lys Phe Phe Ala  Lys Val Val Leu Pro  Leu Ile Asp 
    2915                 2920                 2925             


Gln Tyr  Phe Lys Asn His Arg  Leu Tyr Phe Leu Ser  Ala Ala Ser 
    2930                 2935                 2940             


Arg Pro  Leu Cys Ser Gly Gly  His Ala Ser Asn Lys  Glu Lys Glu 
    2945                 2950                 2955             


Met Val  Thr Ser Leu Phe Cys  Lys Leu Gly Val Leu  Val Arg His 
    2960                 2965                 2970             


Arg Ile  Ser Leu Phe Gly Asn  Asp Ala Thr Ser Ile  Val Asn Cys 
    2975                 2980                 2985             


Leu His  Ile Leu Gly Gln Thr  Leu Asp Ala Arg Thr  Val Met Lys 
    2990                 2995                 3000             


Thr Gly  Leu Glu Ser Val Lys  Ser Ala Leu Arg Ala  Phe Leu Asp 
    3005                 3010                 3015             


Asn Ala  Ala Glu Asp Leu Glu  Lys Thr Met Glu Asn  Leu Lys Gln 
    3020                 3025                 3030             


Gly Gln  Phe Thr His Thr Arg  Asn Gln Pro Lys Gly  Val Thr Gln 
    3035                 3040                 3045             


Ile Ile  Asn Tyr Thr Thr Val  Ala Leu Leu Pro Met  Leu Ser Ser 
    3050                 3055                 3060             


Leu Phe  Glu His Ile Gly Gln  His Gln Phe Gly Glu  Asp Leu Ile 
    3065                 3070                 3075             


Leu Glu  Asp Val Gln Val Ser  Cys Tyr Arg Ile Leu  Thr Ser Leu 
    3080                 3085                 3090             


Tyr Ala  Leu Gly Thr Ser Lys  Ser Ile Tyr Val Glu  Arg Gln Arg 
    3095                 3100                 3105             


Ser Ala  Leu Gly Glu Cys Leu  Ala Ala Phe Ala Gly  Ala Phe Pro 
    3110                 3115                 3120             


Val Ala  Phe Leu Glu Thr His  Leu Asp Lys His Asn  Ile Tyr Ser 
    3125                 3130                 3135             


Ile Tyr  Asn Thr Lys Ser Ser  Arg Glu Arg Ala Ala  Leu Ser Leu 
    3140                 3145                 3150             


Pro Thr  Asn Val Glu Asp Val  Cys Pro Asn Ile Pro  Ser Leu Glu 
    3155                 3160                 3165             


Lys Leu  Met Glu Glu Ile Val  Glu Leu Ala Glu Ser  Gly Ile Arg 
    3170                 3175                 3180             


Tyr Thr  Gln Met Pro His Val  Met Glu Val Ile Leu  Pro Met Leu 
    3185                 3190                 3195             


Cys Ser  Tyr Met Ser Arg Trp  Trp Glu His Gly Pro  Glu Asn Asn 
    3200                 3205                 3210             


Pro Glu  Arg Ala Glu Met Cys  Cys Thr Ala Leu Asn  Ser Glu His 
    3215                 3220                 3225             


Met Asn  Thr Leu Leu Gly Asn  Ile Leu Lys Ile Ile  Tyr Asn Asn 
    3230                 3235                 3240             


Leu Gly  Ile Asp Glu Gly Ala  Trp Met Lys Arg Leu  Ala Val Phe 
    3245                 3250                 3255             


Ser Gln  Pro Ile Ile Asn Lys  Val Lys Pro Gln Leu  Leu Lys Thr 
    3260                 3265                 3270             


His Phe  Leu Pro Leu Met Glu  Lys Leu Lys Lys Lys  Ala Ala Thr 
    3275                 3280                 3285             


Val Val  Ser Glu Glu Asp His  Leu Lys Ala Glu Ala  Arg Gly Asp 
    3290                 3295                 3300             


Met Ser  Glu Ala Glu Leu Leu  Ile Leu Asp Glu Phe  Thr Thr Leu 
    3305                 3310                 3315             


Ala Arg  Asp Leu Tyr Ala Phe  Tyr Pro Leu Leu Ile  Arg Phe Val 
    3320                 3325                 3330             


Asp Tyr  Asn Arg Ala Lys Trp  Leu Lys Glu Pro Asn  Pro Glu Ala 
    3335                 3340                 3345             


Glu Glu  Leu Phe Arg Met Val  Ala Glu Val Phe Ile  Tyr Trp Ser 
    3350                 3355                 3360             


Lys Ser  His Asn Phe Lys Arg  Glu Glu Gln Asn Phe  Val Val Gln 
    3365                 3370                 3375             


Asn Glu  Ile Asn Asn Met Ser  Phe Leu Ile Thr Asp  Thr Lys Ser 
    3380                 3385                 3390             


Lys Met  Ser Lys Ala Ala Val  Ser Asp Gln Glu Arg  Lys Lys Met 
    3395                 3400                 3405             


Lys Arg  Lys Gly Asp Arg Tyr  Ser Met Gln Thr Ser  Leu Ile Val 
    3410                 3415                 3420             


Ala Ala  Leu Lys Arg Leu Leu  Pro Ile Gly Leu Asn  Ile Cys Ala 
    3425                 3430                 3435             


Pro Gly  Asp Gln Glu Leu Ile  Ala Leu Ala Lys Asn  Arg Phe Ser 
    3440                 3445                 3450             


Leu Lys  Asp Thr Glu Asp Glu  Val Arg Asp Ile Ile  Arg Ser Asn 
    3455                 3460                 3465             


Ile His  Leu Gln Gly Lys Leu  Glu Asp Pro Ala Ile  Arg Trp Gln 
    3470                 3475                 3480             


Met Ala  Leu Tyr Lys Asp Leu  Pro Asn Arg Thr Asp  Asp Thr Ser 
    3485                 3490                 3495             


Asp Pro  Glu Lys Thr Val Glu  Arg Val Leu Asp Ile  Ala Asn Val 
    3500                 3505                 3510             


Leu Phe  His Leu Glu Gln Lys  Ser Lys Arg Val Gly  Arg Arg His 
    3515                 3520                 3525             


Tyr Cys  Leu Arg Trp Asn Ile  Leu Arg Asp Leu Lys  Arg Leu Tyr 
    3530                 3535                 3540             


Gly Ile  Asn Tyr Cys Pro Ser  Arg Gly Lys Gly Leu  Leu 
    3545                 3550                 3555     

<210>  1398
<211>  16539
<212>  DNA
<213>  Homo sapiens

<400>  1398
gcgcggcccc ctccagcccc cggctcccgg cagcagaagc agaaggcagc gccaggggcc     60

gccgccgccg ccgagctccg cggggctcgg gagccggccc cggcgaggag gcgcggaacc    120

atggccgatg ggggcgaggg cgaagacgag atccagttcc tgcgaactga gaatgtgccc    180

ccagacctct ccatctgcac ctttgtgctg gagcagtccc tctctgtccg ggcgctgcag    240

gagatgctgg ctaacaccgt ggagaaatca gaaggggcaa ttgatgtgga aaaatggact    300

gctcaaggtg gtggtcatcg aacactcctc tacggacatg ccatattgct gcgccattcc    360

tatagtggca tgtatctgtg ctgcctgtcc acctcccggt cttcaactga taagctggct    420

tttgatgttg gcttgcaaga ggacaccaca ggggaggctt gttggtggac catacaccct    480

gcctctaagc agcgatcaga aggagaaaaa gtacgagttg gagatgacct catcttagtt    540

agcgtgtcct ctgaaaggta cttgcacttg tcttatggca acggcagctt acacgtggat    600

gccgctttcc agcagactct ctggagcgtg gccccaatca gctcaggaag tgaggcagcc    660

caagggtatc tcattggtgg tgatgtcctc aggttgctgc atggacacat ggacgagtgt    720

ctcactgtcc cttcaggaga acatggtgaa gagcagcgga gaactgttca ttatgaaggt    780

ggcgctgtgt ctgttcatgc acgttccctt tggagactag agacgctaag agttgcgtgg    840

agtggaagcc acataagatg gggacagcca ttccgactac gccatgtcac aacaggaaaa    900

tacttgagtc tcatggaaga caaaaacctt ctactcatgg acaaagagaa agctgatgta    960

aaatcaacag catttacctt ccggtcttcc aaggaaaaat tggatgtagg ggtgagaaaa   1020

gaagtagatg gcatgggaac atctgaaata aaatacggtg actcagtatg ctatatacaa   1080

catgtagaca caggcctatg gcttacttac cagtctgtgg acgtgaaatc cgtgagaatg   1140

ggatctatac aacgtaaggc tattatgcat catgaaggcc acatggatga tggcataagt   1200

ttgtcgagat cccagcatga agaatcacgc acagcccgag ttatccggag cacagtcttc   1260

cttttcaata gatttataag gggccttgat gctctcagca agaaagcgaa ggcttccaca   1320

gtcgatttgc ctatagagtc cgtaagccta agtctgcagg atctcattgg ctacttccac   1380

cccccagatg agcatttaga gcatgaagac aaacagaaca gactacgagc cctgaagaat   1440

cggcaaaatc tcttccagga agagggaatg atcaacctcg tgcttgagtg catagaccgt   1500

ttgcacgtct acagcagtgc agcacacttt gctgatgttg ctgggcgaga agcaggagag   1560

tcttggaaat ccattctgaa ttctctgtat gagttgctgg cggctctaat tagaggaaat   1620

cgtaaaaact gtgctcaatt ttctggctcc ctcgactggt tgatcagcag attggaaaga   1680

ctggaagctt cttcaggcat tctggaagtt ttacactgtg ttttagtaga aagtccagaa   1740

gctctaaata ttattaaaga aggacatatt aaatctatta tctcactttt agacaaacat   1800

ggaagaaatc acaaggttct ggatgtcttg tgctcactct gtgtttgcca cggggttgca   1860

gtccgttcta accagcatct catctgtgac aatctcctac caggaagaga cttgttattg   1920

cagacacgtc ttgtgaacca tgtcagcagc atgagaccca atatttttct gggcgtcagt   1980

gaaggttctg ctcagtataa gaaatggtac tatgaattga tggtggacca cacagagccc   2040

tttgtgacag ctgaagcaac tcacctgcga gtgggctggg cttccactga aggatattct   2100

ccctaccctg gagggggcga agagtggggt ggaaatggtg ttggagatga tctcttctcc   2160

tatggatttg atggccttca tctctggtca ggttgtattg ctcgtactgt aagctcacca   2220

aaccaacatc tgttaagaac tgatgatgtc atcagttgct gtttagatct gagtgcccca   2280

agcatctcgt tccgaattaa tggacaacct gttcaaggaa tgtttgagaa tttcaacatc   2340

gatggcctct tctttccagt cgttagtttc tctgcaggaa taaaagtacg ctttctgctt   2400

ggagggcgac atggagaatt caaatttctt cctccacctg ggtatgctcc ttgttatgaa   2460

gctgttctgc caaaagaaaa gttgaaagtg gaacacagcc gagagtacaa gcaagaaaga   2520

acttacacac gcgacctgct gggccccaca gtttccctga cgcaagctgc cttcacaccc   2580

atccctgtgg ataccagcca gatcgtgttg cctcctcatc tagaaagaat aagagaaaaa   2640

ctggcagaga atatccatga actctgggtt atgaataaaa ttgagcttgg ctggcagtat   2700

ggtccggtta gagatgacaa caagagacaa cacccatgcc tggtggagtt ctccaagctg   2760

cctgaacagg agcgcaatta caacttacaa atgtcgcttg agaccctgaa gactttgttg   2820

gcattaggat gtcatgtggg tatatcagat gaacatgctg aagacaaggt gaaaaaaatg   2880

aagctaccca agaattacca gctgacaagt ggatacaagc ctgcccctat ggacctgagc   2940

tttatcaaac tcaccccatc acaagaagca atggtggaca agttggcaga aaatgcacat   3000

aatgtgtggg cgcgggatcg aatccggcag ggctggactt atggcatcca acaggacgta   3060

aagaacagaa gaaatcctcg ccttgttccc tacactcttc tggatgaccg aaccaagaaa   3120

tccaacaagg acagcctccg cgaggctgtg cgcacgctgc tggggtacgg ctacaacttg   3180

gaagcaccag atcaagatca tgcagccaga gccgaagtgt gcagcggcac cggggaaagg   3240

ttccgaatct tccgtgccga gaagacctat gcagtgaagg ccggacggtg gtattttgaa   3300

tttgagacgg tcactgctgg agacatgagg gttggttgga gtcgtcctgg ttgtcaaccg   3360

gatcaggagc ttggctcaga tgaacgtgcc tttgcctttg atggcttcaa ggcccagcgg   3420

tggcatcagg gcaatgaaca ctatgggcgc tcttggcaag caggcgatgt cgtggggtgt   3480

atggttgaca tgaacgaaca caccatgatg ttcacactga atggtgaaat ccttcttgat   3540

gattcaggct cagaactggc tttcaaggac tttgatgttg gcgatggatt catacctgtg   3600

tgtagccttg gagtggctca agtgggtagg atgaactttg gaaaggatgt cagcaccttg   3660

aaatatttca ccatctgtgg cttacaagag ggctatgaac catttgccgt taatacaaac   3720

agggatatta ccatgtggct gagcaagagg cttcctcagt ttcttcaagt tccatcaaac   3780

catgaacata tagaggtgac cagaatagac ggcaccatag acagttcccc atgtttaaag   3840

gtcactcaga agtcttttgg ttctcagaac agcaacactg atatcatgtt ttatcgcctg   3900

agcatgccga tcgagtgcgc ggaggtcttc tccaagacgg tggctggagg gctccctggg   3960

gctggccttt ttgggcccaa gaatgacttg gaagattatg atgctgattc tgactttgag   4020

gttctgatga agacagctca tggccatcta gtgcccgatc gtgttgacaa agacaaagaa   4080

gctactaaac cagagtttaa caaccacaaa gattatgccc aggaaaagcc ctctcgtctg   4140

aaacaaagat ttttgcttag aagaacaaag ccagattaca gcacaagcca ttctgcaaga   4200

ctcaccgaag atgtccttgc tgatgatcgg gatgactatg atttcttgat gcaaacgtcc   4260

acgtactatt actcagtgag aatctttcct ggacaagaac ctgctaatgt ctgggtgggc   4320

tggattacat cagatttcca tcagtatgac acaggctttg acttggacag agttcgcaca   4380

gtaacagtta ctctaggaga tgaaaaagga aaagtgcatg aaagcatcaa acgcagcaac   4440

tgctatatgg tatgtgcggg tgagagcatg agccccgggc aaggacgcaa caataatgga   4500

ctggagattg gctgtgtggt ggatgctgcc agcgggctgc tcacattcat tgccaatggc   4560

aaggaactga gcacatacta tcaggtggaa ccgagtacaa aattatttcc tgcggttttt   4620

gcacaagcta caagtcccaa tgttttccag tttgagttgg gaagaataaa gaatgtgatg   4680

cctctctcgg cgggattatt caagagtgag cacaagaacc ccgtgccgca gtgccccccg   4740

cgcctccacg tgcagttcct gtcacacgtc ctgtggagca gaatgcccaa ccagtttttg   4800

aaggtagatg tgtctcgaat aagtgaacgc caaggctggt tggtgcagtg tttggatcct   4860

ctgcagttca tgtctcttca tatccctgag gaaaacagat ctgttgacat cttagagttg   4920

acagagcagg aggaattgct gaaatttcac tatcacactc tccggctcta ctcagccgtc   4980

tgtgctcttg ggaaccaccg ggtggcccat gccctgtgca gccatgtgga tgaacctcag   5040

ctcctctatg ccattgagaa caagtacatg cctggtttgc tgcgtgctgg ctactatgac   5100

ctgctgattg acatccacct gagctcctat gccactgcca ggctcatgat gaacaacgag   5160

tacattgtcc ccatgacgga ggagacgaag agcatcaccc tgttccctga tgagaacaaa   5220

aaacacggcc ttccagggat cggcctcagc acctccctca ggccacggat gcagttttcc   5280

tcccccagtt ttgtaagcat tagtaatgaa tgttaccagt acagtccaga gttcccactg   5340

gacatcctca agtccaaaac catacagatg ctgacagaag ctgttaaaga gggcagtctt   5400

catgcccggg acccagttgg agggactact gaattcctct ttgtacctct catcaagctt   5460

ttctataccc tgctgatcat gggcatcttt cacaacgagg acttgaagca catcttgcag   5520

ttgattgagc ccagtgtgtt taaagaagct gccactccgg aggaggagag tgacacgctg   5580

gagaaagagc tcagtgtgga cgatgcaaag ctgcaaggag ctggtgagga agaagccaag   5640

gggggcaagc ggcccaagga aggcctgctc caaatgaaac tgccagagcc agttaaattg   5700

cagatgtgcc tactgcttca gtacctctgt gactgccagg tccggcaccg gatagaagcc   5760

attgtagcct tttcagatga ttttgtggct aagctccaag acaatcaacg tttccgatac   5820

aacgaagtca tgcaagcctt aaacatgtca gctgcactca cagccaggaa gacaaaggaa   5880

tttagatcac cacctcaaga acagatcaat atgcttctca attttaagga tgacaaaagt   5940

gaatgtccat gtccagaaga aattcgtgac caactattgg atttccatga agatttgatg   6000

acacattgtg gaattgagct ggatgaagat gggtctctgg atggaaacag tgatttaaca   6060

attagagggc gtctgctatc cctggtagaa aaggtgacat atctgaagaa gaagcaagca   6120

gaaaaaccag ttgagagtga ctccaaaaag tcctccactc tgcagcagct gatttctgag   6180

accatggtcc gatgggctca ggagtctgtc attgaagacc ccgagctggt gagggccatg   6240

tttgtgttgc tccatcggca gtatgacggc attgggggtc ttgttcgggc cctgccaaag   6300

acctacacga taaatggtgt gtccgtggag gacaccatca acctgctggc atcccttggt   6360

cagattcggt ccctgctgag tgtgagaatg ggcaaagaag aagagaagct catgattcgt   6420

ggattagggg atattatgaa taacaaagtg ttttaccagc accctaatct catgagggca   6480

ctggggatgc acgagactgt gatggaggtc atggtgaacg tccttggagg tggagagtcc   6540

aaggaaatca cctttcccaa gatggtggcc aactgttgcc gttttctctg ttacttctgt   6600

cgtataagta ggcagaatca aaaagctatg tttgatcatc tcagttattt actggaaaac   6660

agcagtgttg gtcttgcctc cccagctatg agaggttcaa caccactgga tgtggctgca   6720

gcttcggtga tggataataa tgaactagca ttagctctgc gtgagccgga tctagaaaag   6780

gtagttcgtt atttggctgg ttgtggactg caaagttgcc agatgctggt gtctaagggc   6840

tatccagaca ttgggtggaa cccagttgaa ggagagagat atcttgactt tcttagattt   6900

gctgtcttct gtaatgggga gagtgtggag gaaaatgcaa atgtcgtggt gagattgctc   6960

attcggaggc ctgagtgttt tggtcctgct ttgagaggag aaggtgggaa tgggcttctt   7020

gcagcaatgg aagaagccat caaaatcgcc gaggatcctt cccgagatgg tccctcacca   7080

aatagcggat ccagtaaaac acttgacaca gaggaggagg aagatgacac tatccacatg   7140

gggaacgcga tcatgacctt ctattcagct ttgattgacc tcttgggacg ctgtgctcct   7200

gagatgcatt tgattcatgc cgggaaggga gaagccatca gaattaggtc cattttgaga   7260

tccctcattc ccctgggaga tttggtgggc gttatcagca tcgcttttca gatgccaaca   7320

atagccaaag atgggaatgt ggtggaacct gacatgtctg cggggttttg cccagatcac   7380

aaggcagcca tggttttatt ccttgacagg gtctatggga ttgaggttca agacttcctc   7440

ctccatcttc ttgaggttgg ctttctgcca gatctccggg cggctgcttc tttagatacg   7500

gcagctttga gtgctacaga catggccttg gccctcaatc ggtacctttg cacagccgtc   7560

ttgccattgt taacaagatg tgctcctctc tttgctggca cagagcacca cgcttctctc   7620

attgactcat tacttcatac tgtgtataga ctttctaagg gctgttcact taccaaagct   7680

cagcgggatt ccatagaagt ttgtttactc tctatttgtg gacaactgag accttctatg   7740

atgcagcact tactcagaag attagtattt gatgttccat tattaaatga acacgcaaag   7800

atgcctctta aactgctgac aaatcattat gaaagatgct ggaaatatta ctgcctgcct   7860

ggagggtggg gaaactttgg tgctgcctca gaagaagaac ttcatttatc aagaaagttg   7920

ttctggggca tttttgatgc cctgtctcaa aagaaatatg aacaagaact tttcaaactg   7980

gcactgcctt gcctgagtgc agttgcggga gctttgcctc cagactacat ggagtcaaat   8040

tatgtcagta tgatggaaaa acagtcatca atggattctg aagggaactt taacccacaa   8100

cctgttgata cctcaaatat tacaattcct gagaaattgg aatacttcat taacaaatat   8160

gcagaacact cccatgacaa atggtcaatg gacaagttgg caaatggatg gatttatgga   8220

gaaatatatt cagactcttc taaggttcag ccattaatga agccatataa gctattgtct   8280

gaaaaggaaa aagaaattta tcgctggcca atcaaagaat ctttaaaaac tatgctggct   8340

tggggctgga gaattgaaag aactcgggag ggagacagca tggcccttta caaccggact   8400

cgtcgtattt ctcagacaag ccaggtttct gtggacgctg cccatggtta cagtccccgg   8460

gccattgaca tgagcaatgt tacactatct agagacctgc atgctatggc agaaatgatg   8520

gctgaaaact accataatat atgggcaaag aaaaagaaaa tggagttgga gtccaaagga   8580

ggaggaaacc atcctctgct ggtgccctat gatacactga cagccaaaga gaaagccaag   8640

gatagagaaa aagcacagga catcctcaag ttcttgcaga tcaatggata tgctgtatcc   8700

agaggattta aggacctgga actggacacg ccttctattg agaaacgatt tgcctatagt   8760

ttcctccaac aactcattcg ctatgtggat gaagcccatc agtatatcct ggagtttgat   8820

ggtggcagca gaggcaaagg agaacatttc ccttatgaac aagaaatcaa gttctttgca   8880

aaagtcgttc ttcctttaat tgatcagtat ttcaaaaacc atcgtttata cttcttatct   8940

gcagcaagca gacctctctg ctctggagga catgcttcca acaaagagaa agaaatggtg   9000

actagcctat tctgcaaact tggagttctt gtcaggcata ggatttcact atttggcaat   9060

gatgcaacat caattgtcaa ctgtcttcat attttgggtc agactttgga tgcaaggaca   9120

gtgatgaaga ctggcctgga gagtgttaaa agtgcactca gagcttttct ggacaacgct   9180

gcagaggatc tggagaagac catggaaaac ctcaagcagg gccagttcac tcacacccga   9240

aaccagccca aaggggttac tcagattatc aattacacca cagtggccct gctgccaatg   9300

ctgtcttcat tatttgaaca tattggccag catcagttcg gagaagacct aatattggaa   9360

gatgtccagg tgtcttgtta tagaattctg actagcttat atgctttggg aaccagcaag   9420

agtatttacg tggagaggca acgttctgca ttaggagaat gtctagctgc ctttgctggt   9480

gcttttcctg tagcattttt ggaaactcat ctggacaaac ataatattta ctccatctac   9540

aataccaagt cttcacgaga aagagcagct ctcagtttgc caactaatgt ggaagatgtt   9600

tgtccaaaca taccgtcttt ggagaaactc atggaagaaa tcgtggaatt agccgagtcc   9660

ggcattcgct acactcaaat gccacatgtc atggaagtca tactgcccat gctttgcagc   9720

tacatgtctc gttggtggga gcatggacct gagaacaatc cagaacgggc cgagatgtgc   9780

tgcacagccc tgaactcaga gcacatgaac acacttctag ggaacatatt gaaaatcata   9840

tataataact tggggattga tgagggagcc tggatgaaga ggctagcagt gttttcccag   9900

cctataataa ataaagtgaa acctcagctc ttgaaaactc atttcttgcc gttaatggag   9960

aaactcaaga aaaaggcagc tacggtggtg tctgaggaag accacctgaa agctgaggcc  10020

aggggggaca tgtcggaggc agaactcctc atcctagatg agttcaccac actggccaga  10080

gatctctatg ccttctaccc tctcttgatt agatttgtgg actataacag ggcaaagtgg  10140

ctaaaggagc ctaacccaga agcagaggag ctcttccgca tggtggctga agtgtttatc  10200

tactggtcga agtcccataa tttcaaaaga gaagagcaga acttcgttgt acagaatgaa  10260

atcaacaata tgtctttcct tattactgat accaagtcaa agatgtcaaa ggcagctgtt  10320

tctgatcagg aaaggaagaa aatgaagcgc aaaggagatc ggtattccat gcagacctct  10380

ctgattgtag cagctctgaa gcggttactg cccattgggt tgaacatctg tgcccctggg  10440

gaccaggagc tcattgctct ggccaaaaat cgatttagcc tgaaagatac cgaggatgaa  10500

gtacgagata taatccgcag caatattcat ttacaaggca agttggagga tcctgctatt  10560

agatggcaaa tggctcttta caaagactta ccaaacagga ctgatgatac ctcagatcca  10620

gagaagacgg tagaaagagt attggatata gcaaatgtgc tttttcatct tgaacagaag  10680

tctaaacgtg tgggtcggag acattactgt ctcaggtgga acatcctcag agatctaaaa  10740

aggctgtatg gcataaacta ctgtccaagc agaggaaaag ggctgttgta gcctgcttcc  10800

ggatggcccc cttatataat ctgccaaggc atcgggctgt caatctcttt cttcagggat  10860

atgaaaagtc ttggattgaa acagaagaac attactttga agataaactg atagaagatt  10920

tagcaaaacc tggggctgaa cctccagaag aagatgaagg cactaagaga gttgatcctc  10980

tacatcagct gatccttctg tttagtcgga cagctttaac agagaaatgc aaactggagg  11040

aagatttttt atatatggcc tatgcagata ttatggcaaa gagttgtcat gatgaggaag  11100

atgacgatgg tgaagaggaa gtgaagagtt ttgaagaaaa agaaatggaa aagcaaaagc  11160

ttctatacca gcaagcccga ctccacgatc gtggcgcggc tgagatggtg ctacagacaa  11220

tcagtgccag caaaggtgaa actggaccaa tggtagcagc tactctgaaa cttggaattg  11280

ctattttaaa tggtgggaac tccacagtac agcagaaaat gcttgactac ctcaaggaga  11340

aaaaggatgt gggcttcttt cagagcctgg ccggcctgat gcagtcatgt agtgtccttg  11400

acctaaatgc atttgagcga caaaacaaag ctgaaggtct tgggatggtg acagaggaag  11460

gatcaggaga aaaggttctg caggacgatg agttcacctg tgacctcttc cgattcctgc  11520

aactactctg tgagggacac aactcagatt ttcagaatta tctgagaact cagactggca  11580

ataatacaac tgtcaacata attatctcca ctgtagacta cctactgaga gttcaggaat  11640

caattagtga cttttattgg tattactctg ggaaagatgt tattgatgaa caaggacaac  11700

ggaatttctc caaagctatc caagtggcaa aacaagtctt taacactctt acagagtata  11760

ttcagggtcc ttgcactggg aatcaacaga gtttggcaca cagcaggctg tgggatgctg  11820

tggtcggctt tcttcatgtg tttgcccata tgcagatgaa gctgtcgcag gattccagtc  11880

aaattgagct attaaaagaa ttaatggatc tgcagaagga tatggtggtc atgttgctgt  11940

ccatgttaga aggtaatgtt gttaatggaa cgattggcaa acagatggtg gatatgcttg  12000

tggaatcttc caacaacgtg gagatgattc tcaaattttt tgacatgttc ttaaaactaa  12060

aggatttgac gtcgtctgat acttttaaag aatatgaccc cgatggcaag ggagtcattt  12120

ccaagaggga cttccacaaa gcgatggaga gccataagca ctacacgcag tcagaaacgg  12180

aatttctttt gtcttgtgcg gagacggatg agaatgaaac cctcgactac gaagagttcg  12240

tcaaacgctt ccacgaacct gcgaaggaca tcggcttcaa cgtcgccgtc cttctgacaa  12300

acctctctga gcacatgccc aacgataccc gacttcagac ttttctggaa ttagcagaga  12360

gcgtcctgaa ttatttccag ccctttctgg gccgcatcga aatcatggga agcgccaaac  12420

gcatcgagag ggtctatttt gaaatcagtg agtccagccg aacccagtgg gagaagcccc  12480

aggtcaagga gtccaaaaga cagttcatat ttgacgtggt caacgaaggc ggagagaaag  12540

agaagatgga actctttgtg aacttctgcg aggacaccat ctttgaaatg cagctggcgg  12600

ctcagatctc ggagtcggac ttgaacgaga ggtcagcgaa taaggaagaa agcgagaagg  12660

agaggccgga agagcagggg ccgaggatgg ctttcttctc cattctgacg gtcaggtcgg  12720

ccctgtttgc gctcaggtac aatatcttga cccttatgcg aatgctcagt ctgaagagcc  12780

tgaagaagca gatgaaaaaa gtaaaaaaga tgaccgtgaa ggacatggtc acggccttct  12840

tttcatccta ctggagtatt ttcatgaccc tcttgcactt cgtggccagc gttttcagag  12900

gctttttccg catcatttgc agcctgctgc ttgggggaag cctcgtcgaa ggtgctaaaa  12960

agatcaaagt tgcagaactg ttagccaaca tgccagaccc cactcaggat gaggttagag  13020

gagatgggga ggagggagag aggaaacccc tggaagccgc cctgccctcc gaggatctga  13080

ccgacttaaa ggagctgaca gaggaaagtg accttctttc ggacatcttt ggcctggatc  13140

tgaagagaga aggaggacag tacaaactga ttcctcataa tccaaatgct gggctcagtg  13200

acctcatgag caacccagtc cccatgcctg aggtgcagga aaaatttcag gaacagaagg  13260

caaaagaaga agaaaaggaa gaaaaagaag aaaccaaatc tgaacctgaa aaagccgagg  13320

gagaagatgg agaaaaagaa gagaaagcca aggaagacaa gggcaaacaa aagttgaggc  13380

agcttcacac acacagatac ggagaaccag aagtgccaga gtcagcattc tggaagaaaa  13440

tcatagcata tcaacagaaa cttctaaact attttgctcg caacttttac aacatgagaa  13500

tgttagcctt atttgtcgca tttgctatca atttcatctt gctcttttat aaggtctcca  13560

cttcttctgt ggttgaagga aaggagctcc ccacgagaag ttcaagtgaa aatgccaaag  13620

tgacaagcct ggacagcagc tcccatagaa tcatcgcagt tcactatgta ctagaggaga  13680

gcagcggcta catggagccc acgttgcgta tcttagctat tctgcacacg gtcatttctt  13740

tcttctgcat cattggatac tactgcttga aagtcccatt ggttattttt aagcgagaaa  13800

aggaagtggc acggaaattg gaatttgatg ggctttatat tacagaacag ccttcagaag  13860

atgatattaa aggccagtgg gatagactcg taatcaacac acagtcattt cccaacaact  13920

actgggacaa atttgttaaa agaaaggtta tggataaata tggagagttc tacggccgag  13980

acagaatcag tgaattactt ggcatggaca aggcagctct ggacttcagt gatgccagag  14040

aaaagaagaa gccaaagaaa gacagctcct tatcagctgt actgaactcc attgatgtga  14100

agtatcagat gtggaaacta ggagtcgttt tcactgacaa ctccttcctc tacctagcct  14160

ggtatatgac tatgtctgtt cttggacact ataacaactt tttttttgcc gctcaccttc  14220

tcgacattgc tatgggattc aagacattaa gaaccatctt gtcctcagta actcacaatg  14280

gcaaacagct cgtattaacc gttggcttat tagctgttgt tgtataccta tacactgtgg  14340

tggcattcaa ttttttccga aaattctaca ataaaagtga agatggtgat acaccagata  14400

tgaaatgtga cgatatgcta acatgctata tgttccacat gtatgttgga gttcgtgctg  14460

gaggagggat cggggatgaa atcgaagacc cagcaggaga tgaatatgag atctatcgaa  14520

tcatctttga catcactttc ttcttctttg ttattgtcat tctcttggcc ataatacaag  14580

gtctaattat tgatgctttt ggagaactaa gagaccaaca ggaacaagtc aaagaagaca  14640

tggagaccaa atgcttcatc tgtgggatag gcaatgatta cttcgacaca gtgccacatg  14700

gctttgaaac ccacacttta caggagcaca acttggctaa ttacttgttt tttctgatgt  14760

atcttataaa caaagatgaa acagaacaca caggacagga atcttatgtc tggaagatgt  14820

atcaagaaag gtgttgggaa tttttcccag caggggattg cttccggaaa cagtatgaag  14880

accagctaaa ttaaactcag acccaatcac ctctaaaaac caaaacccta cccctctctc  14940

tccctctctc aatttctctg ctctcttgga aacattttgc tgattttgtg aattgccagc  15000

gttgtgtgtt ttctgggagc atcgaagctc tgtttcggaa gagctgtttc ctccccccac  15060

cttttgtatt tactttgaga ctaaagactg aagaataatc taaattcata ctcagacaaa  15120

aaaaggaatt ctggaaagaa aaccattctg gacactgtca taacacacat agatagattt  15180

tcttctgaga ctcccggagt cttctcgagc tacgagacct tcacagagac acgtggcagc  15240

cacactcacc cagcctcttt atttcaccat cctggaagga aactgtctgt ctaatggtca  15300

cagagcactg tagcacttaa cagattgcca tggacaccag ttgcgaaggg aaatagtgcc  15360

ttactatatg tgggttgagc tatgcagaag atacgtgcat gaaaaaacat ctttattttc  15420

tttatgtcga cctttctttt cttagattga ttttgtgagg tttttttttt ttcctttagt  15480

cttttcttta gtgggggagg gtaagaaaag cagtttgcac ttaaaaagaa aaaaaaaaaa  15540

cgggtggtgt gtctcaggac aaaaggaggc tcttctcatt cagctaaatt cacatttgcc  15600

cccccccccc gcccccgccc ccatatgctc ctgctattat tttggtaatg ctctgatgca  15660

acattgcaac tttatgaaat ctttgtatga aaacaaaaag actgcaaaaa atacactttc  15720

aaaagaaacc attcattgca tgtttattat gcaagtttaa atgaacaaag aaaaccttca  15780

gaaacaagtt gatcaacgtg agagaaattt catgataatt attcatagta ataaagtgtc  15840

gtgggcttaa ttgtatatct ggagccagtg tcatccacca acaatgtgat acaatatgaa  15900

cttgacagta gttttgggtt ttgctcattc tttcagccac ctgtgatcag ttttgttgat  15960

taaggacttc ttgtcaggcc attttttaat atcaaagctg aagcaatatc cattcaggga  16020

tttcatcagt tgcatcacaa aacacggatg ataatataca tcactccatt ttttccattt  16080

tgagtccttt taaatgtaat gctaaccttt acaattaaaa agtcagattc agaatggaaa  16140

caaggtcatt ttgcaaacat tggagctctt ttattacaag tctgcttgtt aattttagaa  16200

ctgtaaaacc gctctgatta aactatttaa ctaactttct catcctcttc tttctccatt  16260

taaaacttat aactgggact cataaaatct tgagcttcta acttgaggtg gatataggac  16320

aatcctaaac actgcactga gacctttaac gctgtcagat ttcctggtac ctctaagact  16380

gttgtgtata taattgtggg gcctcagagt caccaggcac ctggcccacc cctgtcattt  16440

ccctgttata tgggtcagcc agacctcttg aaaacctcca atgacagaaa aaaaagatcg  16500

ctatctccca gattatttaa tttttatata gctctcatt                         16539


<210>  1399
<211>  3556
<212>  PRT
<213>  Homo sapiens

<400>  1399


Met Ala Asp Gly Gly Glu Gly Glu Asp Glu Ile Gln Phe Leu Arg Thr 
1               5                   10                  15      


Glu Asn Val Pro Pro Asp Leu Ser Ile Cys Thr Phe Val Leu Glu Gln 
            20                  25                  30          


Ser Leu Ser Val Arg Ala Leu Gln Glu Met Leu Ala Asn Thr Val Glu 
        35                  40                  45              


Lys Ser Glu Gly Ala Ile Asp Val Glu Lys Trp Thr Ala Gln Gly Gly 
    50                  55                  60                  


Gly His Arg Thr Leu Leu Tyr Gly His Ala Ile Leu Leu Arg His Ser 
65                  70                  75                  80  


Tyr Ser Gly Met Tyr Leu Cys Cys Leu Ser Thr Ser Arg Ser Ser Thr 
                85                  90                  95      


Asp Lys Leu Ala Phe Asp Val Gly Leu Gln Glu Asp Thr Thr Gly Glu 
            100                 105                 110         


Ala Cys Trp Trp Thr Ile His Pro Ala Ser Lys Gln Arg Ser Glu Gly 
        115                 120                 125             


Glu Lys Val Arg Val Gly Asp Asp Leu Ile Leu Val Ser Val Ser Ser 
    130                 135                 140                 


Glu Arg Tyr Leu His Leu Ser Tyr Gly Asn Gly Ser Leu His Val Asp 
145                 150                 155                 160 


Ala Ala Phe Gln Gln Thr Leu Trp Ser Val Ala Pro Ile Ser Ser Gly 
                165                 170                 175     


Ser Glu Ala Ala Gln Gly Tyr Leu Ile Gly Gly Asp Val Leu Arg Leu 
            180                 185                 190         


Leu His Gly His Met Asp Glu Cys Leu Thr Val Pro Ser Gly Glu His 
        195                 200                 205             


Gly Glu Glu Gln Arg Arg Thr Val His Tyr Glu Gly Gly Ala Val Ser 
    210                 215                 220                 


Val His Ala Arg Ser Leu Trp Arg Leu Glu Thr Leu Arg Val Ala Trp 
225                 230                 235                 240 


Ser Gly Ser His Ile Arg Trp Gly Gln Pro Phe Arg Leu Arg His Val 
                245                 250                 255     


Thr Thr Gly Lys Tyr Leu Ser Leu Met Glu Asp Lys Asn Leu Leu Leu 
            260                 265                 270         


Met Asp Lys Glu Lys Ala Asp Val Lys Ser Thr Ala Phe Thr Phe Arg 
        275                 280                 285             


Ser Ser Lys Glu Lys Leu Asp Val Gly Val Arg Lys Glu Val Asp Gly 
    290                 295                 300                 


Met Gly Thr Ser Glu Ile Lys Tyr Gly Asp Ser Val Cys Tyr Ile Gln 
305                 310                 315                 320 


His Val Asp Thr Gly Leu Trp Leu Thr Tyr Gln Ser Val Asp Val Lys 
                325                 330                 335     


Ser Val Arg Met Gly Ser Ile Gln Arg Lys Ala Ile Met His His Glu 
            340                 345                 350         


Gly His Met Asp Asp Gly Ile Ser Leu Ser Arg Ser Gln His Glu Glu 
        355                 360                 365             


Ser Arg Thr Ala Arg Val Ile Arg Ser Thr Val Phe Leu Phe Asn Arg 
    370                 375                 380                 


Phe Ile Arg Gly Leu Asp Ala Leu Ser Lys Lys Ala Lys Ala Ser Thr 
385                 390                 395                 400 


Val Asp Leu Pro Ile Glu Ser Val Ser Leu Ser Leu Gln Asp Leu Ile 
                405                 410                 415     


Gly Tyr Phe His Pro Pro Asp Glu His Leu Glu His Glu Asp Lys Gln 
            420                 425                 430         


Asn Arg Leu Arg Ala Leu Lys Asn Arg Gln Asn Leu Phe Gln Glu Glu 
        435                 440                 445             


Gly Met Ile Asn Leu Val Leu Glu Cys Ile Asp Arg Leu His Val Tyr 
    450                 455                 460                 


Ser Ser Ala Ala His Phe Ala Asp Val Ala Gly Arg Glu Ala Gly Glu 
465                 470                 475                 480 


Ser Trp Lys Ser Ile Leu Asn Ser Leu Tyr Glu Leu Leu Ala Ala Leu 
                485                 490                 495     


Ile Arg Gly Asn Arg Lys Asn Cys Ala Gln Phe Ser Gly Ser Leu Asp 
            500                 505                 510         


Trp Leu Ile Ser Arg Leu Glu Arg Leu Glu Ala Ser Ser Gly Ile Leu 
        515                 520                 525             


Glu Val Leu His Cys Val Leu Val Glu Ser Pro Glu Ala Leu Asn Ile 
    530                 535                 540                 


Ile Lys Glu Gly His Ile Lys Ser Ile Ile Ser Leu Leu Asp Lys His 
545                 550                 555                 560 


Gly Arg Asn His Lys Val Leu Asp Val Leu Cys Ser Leu Cys Val Cys 
                565                 570                 575     


His Gly Val Ala Val Arg Ser Asn Gln His Leu Ile Cys Asp Asn Leu 
            580                 585                 590         


Leu Pro Gly Arg Asp Leu Leu Leu Gln Thr Arg Leu Val Asn His Val 
        595                 600                 605             


Ser Ser Met Arg Pro Asn Ile Phe Leu Gly Val Ser Glu Gly Ser Ala 
    610                 615                 620                 


Gln Tyr Lys Lys Trp Tyr Tyr Glu Leu Met Val Asp His Thr Glu Pro 
625                 630                 635                 640 


Phe Val Thr Ala Glu Ala Thr His Leu Arg Val Gly Trp Ala Ser Thr 
                645                 650                 655     


Glu Gly Tyr Ser Pro Tyr Pro Gly Gly Gly Glu Glu Trp Gly Gly Asn 
            660                 665                 670         


Gly Val Gly Asp Asp Leu Phe Ser Tyr Gly Phe Asp Gly Leu His Leu 
        675                 680                 685             


Trp Ser Gly Cys Ile Ala Arg Thr Val Ser Ser Pro Asn Gln His Leu 
    690                 695                 700                 


Leu Arg Thr Asp Asp Val Ile Ser Cys Cys Leu Asp Leu Ser Ala Pro 
705                 710                 715                 720 


Ser Ile Ser Phe Arg Ile Asn Gly Gln Pro Val Gln Gly Met Phe Glu 
                725                 730                 735     


Asn Phe Asn Ile Asp Gly Leu Phe Phe Pro Val Val Ser Phe Ser Ala 
            740                 745                 750         


Gly Ile Lys Val Arg Phe Leu Leu Gly Gly Arg His Gly Glu Phe Lys 
        755                 760                 765             


Phe Leu Pro Pro Pro Gly Tyr Ala Pro Cys Tyr Glu Ala Val Leu Pro 
    770                 775                 780                 


Lys Glu Lys Leu Lys Val Glu His Ser Arg Glu Tyr Lys Gln Glu Arg 
785                 790                 795                 800 


Thr Tyr Thr Arg Asp Leu Leu Gly Pro Thr Val Ser Leu Thr Gln Ala 
                805                 810                 815     


Ala Phe Thr Pro Ile Pro Val Asp Thr Ser Gln Ile Val Leu Pro Pro 
            820                 825                 830         


His Leu Glu Arg Ile Arg Glu Lys Leu Ala Glu Asn Ile His Glu Leu 
        835                 840                 845             


Trp Val Met Asn Lys Ile Glu Leu Gly Trp Gln Tyr Gly Pro Val Arg 
    850                 855                 860                 


Asp Asp Asn Lys Arg Gln His Pro Cys Leu Val Glu Phe Ser Lys Leu 
865                 870                 875                 880 


Pro Glu Gln Glu Arg Asn Tyr Asn Leu Gln Met Ser Leu Glu Thr Leu 
                885                 890                 895     


Lys Thr Leu Leu Ala Leu Gly Cys His Val Gly Ile Ser Asp Glu His 
            900                 905                 910         


Ala Glu Asp Lys Val Lys Lys Met Lys Leu Pro Lys Asn Tyr Gln Leu 
        915                 920                 925             


Thr Ser Gly Tyr Lys Pro Ala Pro Met Asp Leu Ser Phe Ile Lys Leu 
    930                 935                 940                 


Thr Pro Ser Gln Glu Ala Met Val Asp Lys Leu Ala Glu Asn Ala His 
945                 950                 955                 960 


Asn Val Trp Ala Arg Asp Arg Ile Arg Gln Gly Trp Thr Tyr Gly Ile 
                965                 970                 975     


Gln Gln Asp Val Lys Asn Arg Arg Asn Pro Arg Leu Val Pro Tyr Thr 
            980                 985                 990         


Leu Leu Asp Asp Arg Thr Lys Lys  Ser Asn Lys Asp Ser  Leu Arg Glu 
        995                 1000                 1005             


Ala Val  Arg Thr Leu Leu Gly  Tyr Gly Tyr Asn Leu  Glu Ala Pro 
    1010                 1015                 1020             


Asp Gln  Asp His Ala Ala Arg  Ala Glu Val Cys Ser  Gly Thr Gly 
    1025                 1030                 1035             


Glu Arg  Phe Arg Ile Phe Arg  Ala Glu Lys Thr Tyr  Ala Val Lys 
    1040                 1045                 1050             


Ala Gly  Arg Trp Tyr Phe Glu  Phe Glu Thr Val Thr  Ala Gly Asp 
    1055                 1060                 1065             


Met Arg  Val Gly Trp Ser Arg  Pro Gly Cys Gln Pro  Asp Gln Glu 
    1070                 1075                 1080             


Leu Gly  Ser Asp Glu Arg Ala  Phe Ala Phe Asp Gly  Phe Lys Ala 
    1085                 1090                 1095             


Gln Arg  Trp His Gln Gly Asn  Glu His Tyr Gly Arg  Ser Trp Gln 
    1100                 1105                 1110             


Ala Gly  Asp Val Val Gly Cys  Met Val Asp Met Asn  Glu His Thr 
    1115                 1120                 1125             


Met Met  Phe Thr Leu Asn Gly  Glu Ile Leu Leu Asp  Asp Ser Gly 
    1130                 1135                 1140             


Ser Glu  Leu Ala Phe Lys Asp  Phe Asp Val Gly Asp  Gly Phe Ile 
    1145                 1150                 1155             


Pro Val  Cys Ser Leu Gly Val  Ala Gln Val Gly Arg  Met Asn Phe 
    1160                 1165                 1170             


Gly Lys  Asp Val Ser Thr Leu  Lys Tyr Phe Thr Ile  Cys Gly Leu 
    1175                 1180                 1185             


Gln Glu  Gly Tyr Glu Pro Phe  Ala Val Asn Thr Asn  Arg Asp Ile 
    1190                 1195                 1200             


Thr Met  Trp Leu Ser Lys Arg  Leu Pro Gln Phe Leu  Gln Val Pro 
    1205                 1210                 1215             


Ser Asn  His Glu His Ile Glu  Val Thr Arg Ile Asp  Gly Thr Ile 
    1220                 1225                 1230             


Asp Ser  Ser Pro Cys Leu Lys  Val Thr Gln Lys Ser  Phe Gly Ser 
    1235                 1240                 1245             


Gln Asn  Ser Asn Thr Asp Ile  Met Phe Tyr Arg Leu  Ser Met Pro 
    1250                 1255                 1260             


Ile Glu  Cys Ala Glu Val Phe  Ser Lys Thr Val Ala  Gly Gly Leu 
    1265                 1270                 1275             


Pro Gly  Ala Gly Leu Phe Gly  Pro Lys Asn Asp Leu  Glu Asp Tyr 
    1280                 1285                 1290             


Asp Ala  Asp Ser Asp Phe Glu  Val Leu Met Lys Thr  Ala His Gly 
    1295                 1300                 1305             


His Leu  Val Pro Asp Arg Val  Asp Lys Asp Lys Glu  Ala Thr Lys 
    1310                 1315                 1320             


Pro Glu  Phe Asn Asn His Lys  Asp Tyr Ala Gln Glu  Lys Pro Ser 
    1325                 1330                 1335             


Arg Leu  Lys Gln Arg Phe Leu  Leu Arg Arg Thr Lys  Pro Asp Tyr 
    1340                 1345                 1350             


Ser Thr  Ser His Ser Ala Arg  Leu Thr Glu Asp Val  Leu Ala Asp 
    1355                 1360                 1365             


Asp Arg  Asp Asp Tyr Asp Phe  Leu Met Gln Thr Ser  Thr Tyr Tyr 
    1370                 1375                 1380             


Tyr Ser  Val Arg Ile Phe Pro  Gly Gln Glu Pro Ala  Asn Val Trp 
    1385                 1390                 1395             


Val Gly  Trp Ile Thr Ser Asp  Phe His Gln Tyr Asp  Thr Gly Phe 
    1400                 1405                 1410             


Asp Leu  Asp Arg Val Arg Thr  Val Thr Val Thr Leu  Gly Asp Glu 
    1415                 1420                 1425             


Lys Gly  Lys Val His Glu Ser  Ile Lys Arg Ser Asn  Cys Tyr Met 
    1430                 1435                 1440             


Val Cys  Ala Gly Glu Ser Met  Ser Pro Gly Gln Gly  Arg Asn Asn 
    1445                 1450                 1455             


Asn Gly  Leu Glu Ile Gly Cys  Val Val Asp Ala Ala  Ser Gly Leu 
    1460                 1465                 1470             


Leu Thr  Phe Ile Ala Asn Gly  Lys Glu Leu Ser Thr  Tyr Tyr Gln 
    1475                 1480                 1485             


Val Glu  Pro Ser Thr Lys Leu  Phe Pro Ala Val Phe  Ala Gln Ala 
    1490                 1495                 1500             


Thr Ser  Pro Asn Val Phe Gln  Phe Glu Leu Gly Arg  Ile Lys Asn 
    1505                 1510                 1515             


Val Met  Pro Leu Ser Ala Gly  Leu Phe Lys Ser Glu  His Lys Asn 
    1520                 1525                 1530             


Pro Val  Pro Gln Cys Pro Pro  Arg Leu His Val Gln  Phe Leu Ser 
    1535                 1540                 1545             


His Val  Leu Trp Ser Arg Met  Pro Asn Gln Phe Leu  Lys Val Asp 
    1550                 1555                 1560             


Val Ser  Arg Ile Ser Glu Arg  Gln Gly Trp Leu Val  Gln Cys Leu 
    1565                 1570                 1575             


Asp Pro  Leu Gln Phe Met Ser  Leu His Ile Pro Glu  Glu Asn Arg 
    1580                 1585                 1590             


Ser Val  Asp Ile Leu Glu Leu  Thr Glu Gln Glu Glu  Leu Leu Lys 
    1595                 1600                 1605             


Phe His  Tyr His Thr Leu Arg  Leu Tyr Ser Ala Val  Cys Ala Leu 
    1610                 1615                 1620             


Gly Asn  His Arg Val Ala His  Ala Leu Cys Ser His  Val Asp Glu 
    1625                 1630                 1635             


Pro Gln  Leu Leu Tyr Ala Ile  Glu Asn Lys Tyr Met  Pro Gly Leu 
    1640                 1645                 1650             


Leu Arg  Ala Gly Tyr Tyr Asp  Leu Leu Ile Asp Ile  His Leu Ser 
    1655                 1660                 1665             


Ser Tyr  Ala Thr Ala Arg Leu  Met Met Asn Asn Glu  Tyr Ile Val 
    1670                 1675                 1680             


Pro Met  Thr Glu Glu Thr Lys  Ser Ile Thr Leu Phe  Pro Asp Glu 
    1685                 1690                 1695             


Asn Lys  Lys His Gly Leu Pro  Gly Ile Gly Leu Ser  Thr Ser Leu 
    1700                 1705                 1710             


Arg Pro  Arg Met Gln Phe Ser  Ser Pro Ser Phe Val  Ser Ile Ser 
    1715                 1720                 1725             


Asn Glu  Cys Tyr Gln Tyr Ser  Pro Glu Phe Pro Leu  Asp Ile Leu 
    1730                 1735                 1740             


Lys Ser  Lys Thr Ile Gln Met  Leu Thr Glu Ala Val  Lys Glu Gly 
    1745                 1750                 1755             


Ser Leu  His Ala Arg Asp Pro  Val Gly Gly Thr Thr  Glu Phe Leu 
    1760                 1765                 1770             


Phe Val  Pro Leu Ile Lys Leu  Phe Tyr Thr Leu Leu  Ile Met Gly 
    1775                 1780                 1785             


Ile Phe  His Asn Glu Asp Leu  Lys His Ile Leu Gln  Leu Ile Glu 
    1790                 1795                 1800             


Pro Ser  Val Phe Lys Glu Ala  Ala Thr Pro Glu Glu  Glu Ser Asp 
    1805                 1810                 1815             


Thr Leu  Glu Lys Glu Leu Ser  Val Asp Asp Ala Lys  Leu Gln Gly 
    1820                 1825                 1830             


Ala Gly  Glu Glu Glu Ala Lys  Gly Gly Lys Arg Pro  Lys Glu Gly 
    1835                 1840                 1845             


Leu Leu  Gln Met Lys Leu Pro  Glu Pro Val Lys Leu  Gln Met Cys 
    1850                 1855                 1860             


Leu Leu  Leu Gln Tyr Leu Cys  Asp Cys Gln Val Arg  His Arg Ile 
    1865                 1870                 1875             


Glu Ala  Ile Val Ala Phe Ser  Asp Asp Phe Val Ala  Lys Leu Gln 
    1880                 1885                 1890             


Asp Asn  Gln Arg Phe Arg Tyr  Asn Glu Val Met Gln  Ala Leu Asn 
    1895                 1900                 1905             


Met Ser  Ala Ala Leu Thr Ala  Arg Lys Thr Lys Glu  Phe Arg Ser 
    1910                 1915                 1920             


Pro Pro  Gln Glu Gln Ile Asn  Met Leu Leu Asn Phe  Lys Asp Asp 
    1925                 1930                 1935             


Lys Ser  Glu Cys Pro Cys Pro  Glu Glu Ile Arg Asp  Gln Leu Leu 
    1940                 1945                 1950             


Asp Phe  His Glu Asp Leu Met  Thr His Cys Gly Ile  Glu Leu Asp 
    1955                 1960                 1965             


Glu Asp  Gly Ser Leu Asp Gly  Asn Ser Asp Leu Thr  Ile Arg Gly 
    1970                 1975                 1980             


Arg Leu  Leu Ser Leu Val Glu  Lys Val Thr Tyr Leu  Lys Lys Lys 
    1985                 1990                 1995             


Gln Ala  Glu Lys Pro Val Glu  Ser Asp Ser Lys Lys  Ser Ser Thr 
    2000                 2005                 2010             


Leu Gln  Gln Leu Ile Ser Glu  Thr Met Val Arg Trp  Ala Gln Glu 
    2015                 2020                 2025             


Ser Val  Ile Glu Asp Pro Glu  Leu Val Arg Ala Met  Phe Val Leu 
    2030                 2035                 2040             


Leu His  Arg Gln Tyr Asp Gly  Ile Gly Gly Leu Val  Arg Ala Leu 
    2045                 2050                 2055             


Pro Lys  Thr Tyr Thr Ile Asn  Gly Val Ser Val Glu  Asp Thr Ile 
    2060                 2065                 2070             


Asn Leu  Leu Ala Ser Leu Gly  Gln Ile Arg Ser Leu  Leu Ser Val 
    2075                 2080                 2085             


Arg Met  Gly Lys Glu Glu Glu  Lys Leu Met Ile Arg  Gly Leu Gly 
    2090                 2095                 2100             


Asp Ile  Met Asn Asn Lys Val  Phe Tyr Gln His Pro  Asn Leu Met 
    2105                 2110                 2115             


Arg Ala  Leu Gly Met His Glu  Thr Val Met Glu Val  Met Val Asn 
    2120                 2125                 2130             


Val Leu  Gly Gly Gly Glu Ser  Lys Glu Ile Thr Phe  Pro Lys Met 
    2135                 2140                 2145             


Val Ala  Asn Cys Cys Arg Phe  Leu Cys Tyr Phe Cys  Arg Ile Ser 
    2150                 2155                 2160             


Arg Gln  Asn Gln Lys Ala Met  Phe Asp His Leu Ser  Tyr Leu Leu 
    2165                 2170                 2175             


Glu Asn  Ser Ser Val Gly Leu  Ala Ser Pro Ala Met  Arg Gly Ser 
    2180                 2185                 2190             


Thr Pro  Leu Asp Val Ala Ala  Ala Ser Val Met Asp  Asn Asn Glu 
    2195                 2200                 2205             


Leu Ala  Leu Ala Leu Arg Glu  Pro Asp Leu Glu Lys  Val Val Arg 
    2210                 2215                 2220             


Tyr Leu  Ala Gly Cys Gly Leu  Gln Ser Cys Gln Met  Leu Val Ser 
    2225                 2230                 2235             


Lys Gly  Tyr Pro Asp Ile Gly  Trp Asn Pro Val Glu  Gly Glu Arg 
    2240                 2245                 2250             


Tyr Leu  Asp Phe Leu Arg Phe  Ala Val Phe Cys Asn  Gly Glu Ser 
    2255                 2260                 2265             


Val Glu  Glu Asn Ala Asn Val  Val Val Arg Leu Leu  Ile Arg Arg 
    2270                 2275                 2280             


Pro Glu  Cys Phe Gly Pro Ala  Leu Arg Gly Glu Gly  Gly Asn Gly 
    2285                 2290                 2295             


Leu Leu  Ala Ala Met Glu Glu  Ala Ile Lys Ile Ala  Glu Asp Pro 
    2300                 2305                 2310             


Ser Arg  Asp Gly Pro Ser Pro  Asn Ser Gly Ser Ser  Lys Thr Leu 
    2315                 2320                 2325             


Asp Thr  Glu Glu Glu Glu Asp  Asp Thr Ile His Met  Gly Asn Ala 
    2330                 2335                 2340             


Ile Met  Thr Phe Tyr Ser Ala  Leu Ile Asp Leu Leu  Gly Arg Cys 
    2345                 2350                 2355             


Ala Pro  Glu Met His Leu Ile  His Ala Gly Lys Gly  Glu Ala Ile 
    2360                 2365                 2370             


Arg Ile  Arg Ser Ile Leu Arg  Ser Leu Ile Pro Leu  Gly Asp Leu 
    2375                 2380                 2385             


Val Gly  Val Ile Ser Ile Ala  Phe Gln Met Pro Thr  Ile Ala Lys 
    2390                 2395                 2400             


Asp Gly  Asn Val Val Glu Pro  Asp Met Ser Ala Gly  Phe Cys Pro 
    2405                 2410                 2415             


Asp His  Lys Ala Ala Met Val  Leu Phe Leu Asp Arg  Val Tyr Gly 
    2420                 2425                 2430             


Ile Glu  Val Gln Asp Phe Leu  Leu His Leu Leu Glu  Val Gly Phe 
    2435                 2440                 2445             


Leu Pro  Asp Leu Arg Ala Ala  Ala Ser Leu Asp Thr  Ala Ala Leu 
    2450                 2455                 2460             


Ser Ala  Thr Asp Met Ala Leu  Ala Leu Asn Arg Tyr  Leu Cys Thr 
    2465                 2470                 2475             


Ala Val  Leu Pro Leu Leu Thr  Arg Cys Ala Pro Leu  Phe Ala Gly 
    2480                 2485                 2490             


Thr Glu  His His Ala Ser Leu  Ile Asp Ser Leu Leu  His Thr Val 
    2495                 2500                 2505             


Tyr Arg  Leu Ser Lys Gly Cys  Ser Leu Thr Lys Ala  Gln Arg Asp 
    2510                 2515                 2520             


Ser Ile  Glu Val Cys Leu Leu  Ser Ile Cys Gly Gln  Leu Arg Pro 
    2525                 2530                 2535             


Ser Met  Met Gln His Leu Leu  Arg Arg Leu Val Phe  Asp Val Pro 
    2540                 2545                 2550             


Leu Leu  Asn Glu His Ala Lys  Met Pro Leu Lys Leu  Leu Thr Asn 
    2555                 2560                 2565             


His Tyr  Glu Arg Cys Trp Lys  Tyr Tyr Cys Leu Pro  Gly Gly Trp 
    2570                 2575                 2580             


Gly Asn  Phe Gly Ala Ala Ser  Glu Glu Glu Leu His  Leu Ser Arg 
    2585                 2590                 2595             


Lys Leu  Phe Trp Gly Ile Phe  Asp Ala Leu Ser Gln  Lys Lys Tyr 
    2600                 2605                 2610             


Glu Gln  Glu Leu Phe Lys Leu  Ala Leu Pro Cys Leu  Ser Ala Val 
    2615                 2620                 2625             


Ala Gly  Ala Leu Pro Pro Asp  Tyr Met Glu Ser Asn  Tyr Val Ser 
    2630                 2635                 2640             


Met Met  Glu Lys Gln Ser Ser  Met Asp Ser Glu Gly  Asn Phe Asn 
    2645                 2650                 2655             


Pro Gln  Pro Val Asp Thr Ser  Asn Ile Thr Ile Pro  Glu Lys Leu 
    2660                 2665                 2670             


Glu Tyr  Phe Ile Asn Lys Tyr  Ala Glu His Ser His  Asp Lys Trp 
    2675                 2680                 2685             


Ser Met  Asp Lys Leu Ala Asn  Gly Trp Ile Tyr Gly  Glu Ile Tyr 
    2690                 2695                 2700             


Ser Asp  Ser Ser Lys Val Gln  Pro Leu Met Lys Pro  Tyr Lys Leu 
    2705                 2710                 2715             


Leu Ser  Glu Lys Glu Lys Glu  Ile Tyr Arg Trp Pro  Ile Lys Glu 
    2720                 2725                 2730             


Ser Leu  Lys Thr Met Leu Ala  Trp Gly Trp Arg Ile  Glu Arg Thr 
    2735                 2740                 2745             


Arg Glu  Gly Asp Ser Met Ala  Leu Tyr Asn Arg Thr  Arg Arg Ile 
    2750                 2755                 2760             


Ser Gln  Thr Ser Gln Val Ser  Val Asp Ala Ala His  Gly Tyr Ser 
    2765                 2770                 2775             


Pro Arg  Ala Ile Asp Met Ser  Asn Val Thr Leu Ser  Arg Asp Leu 
    2780                 2785                 2790             


His Ala  Met Ala Glu Met Met  Ala Glu Asn Tyr His  Asn Ile Trp 
    2795                 2800                 2805             


Ala Lys  Lys Lys Lys Met Glu  Leu Glu Ser Lys Gly  Gly Gly Asn 
    2810                 2815                 2820             


His Pro  Leu Leu Val Pro Tyr  Asp Thr Leu Thr Ala  Lys Glu Lys 
    2825                 2830                 2835             


Ala Lys  Asp Arg Glu Lys Ala  Gln Asp Ile Leu Lys  Phe Leu Gln 
    2840                 2845                 2850             


Ile Asn  Gly Tyr Ala Val Ser  Arg Gly Phe Lys Asp  Leu Glu Leu 
    2855                 2860                 2865             


Asp Thr  Pro Ser Ile Glu Lys  Arg Phe Ala Tyr Ser  Phe Leu Gln 
    2870                 2875                 2880             


Gln Leu  Ile Arg Tyr Val Asp  Glu Ala His Gln Tyr  Ile Leu Glu 
    2885                 2890                 2895             


Phe Asp  Gly Gly Ser Arg Gly  Lys Gly Glu His Phe  Pro Tyr Glu 
    2900                 2905                 2910             


Gln Glu  Ile Lys Phe Phe Ala  Lys Val Val Leu Pro  Leu Ile Asp 
    2915                 2920                 2925             


Gln Tyr  Phe Lys Asn His Arg  Leu Tyr Phe Leu Ser  Ala Ala Ser 
    2930                 2935                 2940             


Arg Pro  Leu Cys Ser Gly Gly  His Ala Ser Asn Lys  Glu Lys Glu 
    2945                 2950                 2955             


Met Val  Thr Ser Leu Phe Cys  Lys Leu Gly Val Leu  Val Arg His 
    2960                 2965                 2970             


Arg Ile  Ser Leu Phe Gly Asn  Asp Ala Thr Ser Ile  Val Asn Cys 
    2975                 2980                 2985             


Leu His  Ile Leu Gly Gln Thr  Leu Asp Ala Arg Thr  Val Met Lys 
    2990                 2995                 3000             


Thr Gly  Leu Glu Ser Val Lys  Ser Ala Leu Arg Ala  Phe Leu Asp 
    3005                 3010                 3015             


Asn Ala  Ala Glu Asp Leu Glu  Lys Thr Met Glu Asn  Leu Lys Gln 
    3020                 3025                 3030             


Gly Gln  Phe Thr His Thr Arg  Asn Gln Pro Lys Gly  Val Thr Gln 
    3035                 3040                 3045             


Ile Ile  Asn Tyr Thr Thr Val  Ala Leu Leu Pro Met  Leu Ser Ser 
    3050                 3055                 3060             


Leu Phe  Glu His Ile Gly Gln  His Gln Phe Gly Glu  Asp Leu Ile 
    3065                 3070                 3075             


Leu Glu  Asp Val Gln Val Ser  Cys Tyr Arg Ile Leu  Thr Ser Leu 
    3080                 3085                 3090             


Tyr Ala  Leu Gly Thr Ser Lys  Ser Ile Tyr Val Glu  Arg Gln Arg 
    3095                 3100                 3105             


Ser Ala  Leu Gly Glu Cys Leu  Ala Ala Phe Ala Gly  Ala Phe Pro 
    3110                 3115                 3120             


Val Ala  Phe Leu Glu Thr His  Leu Asp Lys His Asn  Ile Tyr Ser 
    3125                 3130                 3135             


Ile Tyr  Asn Thr Lys Ser Ser  Arg Glu Arg Ala Ala  Leu Ser Leu 
    3140                 3145                 3150             


Pro Thr  Asn Val Glu Asp Val  Cys Pro Asn Ile Pro  Ser Leu Glu 
    3155                 3160                 3165             


Lys Leu  Met Glu Glu Ile Val  Glu Leu Ala Glu Ser  Gly Ile Arg 
    3170                 3175                 3180             


Tyr Thr  Gln Met Pro His Val  Met Glu Val Ile Leu  Pro Met Leu 
    3185                 3190                 3195             


Cys Ser  Tyr Met Ser Arg Trp  Trp Glu His Gly Pro  Glu Asn Asn 
    3200                 3205                 3210             


Pro Glu  Arg Ala Glu Met Cys  Cys Thr Ala Leu Asn  Ser Glu His 
    3215                 3220                 3225             


Met Asn  Thr Leu Leu Gly Asn  Ile Leu Lys Ile Ile  Tyr Asn Asn 
    3230                 3235                 3240             


Leu Gly  Ile Asp Glu Gly Ala  Trp Met Lys Arg Leu  Ala Val Phe 
    3245                 3250                 3255             


Ser Gln  Pro Ile Ile Asn Lys  Val Lys Pro Gln Leu  Leu Lys Thr 
    3260                 3265                 3270             


His Phe  Leu Pro Leu Met Glu  Lys Leu Lys Lys Lys  Ala Ala Thr 
    3275                 3280                 3285             


Val Val  Ser Glu Glu Asp His  Leu Lys Ala Glu Ala  Arg Gly Asp 
    3290                 3295                 3300             


Met Ser  Glu Ala Glu Leu Leu  Ile Leu Asp Glu Phe  Thr Thr Leu 
    3305                 3310                 3315             


Ala Arg  Asp Leu Tyr Ala Phe  Tyr Pro Leu Leu Ile  Arg Phe Val 
    3320                 3325                 3330             


Asp Tyr  Asn Arg Ala Lys Trp  Leu Lys Glu Pro Asn  Pro Glu Ala 
    3335                 3340                 3345             


Glu Glu  Leu Phe Arg Met Val  Ala Glu Val Phe Ile  Tyr Trp Ser 
    3350                 3355                 3360             


Lys Ser  His Asn Phe Lys Arg  Glu Glu Gln Asn Phe  Val Val Gln 
    3365                 3370                 3375             


Asn Glu  Ile Asn Asn Met Ser  Phe Leu Ile Thr Asp  Thr Lys Ser 
    3380                 3385                 3390             


Lys Met  Ser Lys Ala Ala Val  Ser Asp Gln Glu Arg  Lys Lys Met 
    3395                 3400                 3405             


Lys Arg  Lys Gly Asp Arg Tyr  Ser Met Gln Thr Ser  Leu Ile Val 
    3410                 3415                 3420             


Ala Ala  Leu Lys Arg Leu Leu  Pro Ile Gly Leu Asn  Ile Cys Ala 
    3425                 3430                 3435             


Pro Gly  Asp Gln Glu Leu Ile  Ala Leu Ala Lys Asn  Arg Phe Ser 
    3440                 3445                 3450             


Leu Lys  Asp Thr Glu Asp Glu  Val Arg Asp Ile Ile  Arg Ser Asn 
    3455                 3460                 3465             


Ile His  Leu Gln Gly Lys Leu  Glu Asp Pro Ala Ile  Arg Trp Gln 
    3470                 3475                 3480             


Met Ala  Leu Tyr Lys Asp Leu  Pro Asn Arg Thr Asp  Asp Thr Ser 
    3485                 3490                 3495             


Asp Pro  Glu Lys Thr Val Glu  Arg Val Leu Asp Ile  Ala Asn Val 
    3500                 3505                 3510             


Leu Phe  His Leu Glu Gln Lys  Ser Lys Arg Val Gly  Arg Arg His 
    3515                 3520                 3525             


Tyr Cys  Leu Arg Trp Asn Ile  Leu Arg Asp Leu Lys  Arg Leu Tyr 
    3530                 3535                 3540             


Gly Ile  Asn Tyr Cys Pro Ser  Arg Gly Lys Gly Leu  Leu 
    3545                 3550                 3555     

<210>  1400
<211>  598
<212>  DNA
<213>  Homo sapiens

<400>  1400
atcttatgca aacaggcttt ccacttggca ggtgccatgt tgcctgctcc ttactgtaca     60

cgtggctggc aaggagacgg gaacatggag ccgccatttt gaacatgcct agtcccaggt    120

ggtcttttcc tattggcaca actgctggca ttcacccgtg gaagcttcca acttgcttct    180

ctatgtctgc agctcgattt tgcaggctgc tctttgttag aaaagaacat gattttggga    240

ctgctcttca ttaaaaggca ttctggaagt tttacactgt gttttagtag aaagtccaga    300

agctctaaat attattaaag aaggacatat taaatctatt atctcacttt tagacaaaca    360

tggaagaaat cacaaggttc tggatgtctt gtgctcactc tgtgtttgcc acggggttgc    420

agtccgttct aaccagcatc tcatctgtga caatctccta ccaggaagag acttgttatt    480

gcagacacgt cttgtgaacc atgtcagcag catgagaccc aatatttttc tgggcgtcag    540

tgaaggttct gctcagtata agaaatggta ctatgaattg atggtggacc acacagag      598


<210>  1401
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  1401


Met Glu Glu Ile Thr Arg Phe Trp Met Ser Cys Ala His Ser Val Phe 
1               5                   10                  15      


Ala Thr Gly Leu Gln Ser Val Leu Thr Ser Ile Ser Ser Val Thr Ile 
            20                  25                  30          


Ser Tyr Gln Glu Glu Thr Cys Tyr Cys Arg His Val Leu 
        35                  40                  45  

<210>  1402
<211>  541
<212>  DNA
<213>  Homo sapiens

<400>  1402
ctttaatgta caccagagat aaaattgact ctaacgtgca tcctctttag agtacgcttt     60

ctgcttggag ggcgacatgg agaattcaaa tttcttcctc cacctgggta tgctccttgt    120

tatgaagctg ttctgccaaa agaaaagttg aaagtggaac acagccgaga gtacaagcaa    180

gaaagaactt acacacgcga cctgctgggc cccacagttt ccctgacgca agctgccttc    240

acacccatcc ctgtggatac cagccagatc gtgttgcctc ctcatctaga aagaataaga    300

gaaaaactgg cagagaatat ccatgaactc tgggttatga ataaaattga gcttggctgg    360

cagtatggtc cggttagaga tgacaacaag agacaacacc catgcctggt ggagttctcc    420

aagctgcctg aacaggagcg caattacaac ttacaaatgt cgcttgagac cctgaagtga    480

gtttcttaac tttttctatt ttccaacctg ccttccctga aaaaaaaaaa aaaaaaaaaa    540

a                                                                    541


<210>  1403
<211>  47
<212>  PRT
<213>  Homo sapiens

<400>  1403


Met Asn Lys Ile Glu Leu Gly Trp Gln Tyr Gly Pro Val Arg Asp Asp 
1               5                   10                  15      


Asn Lys Arg Gln His Pro Cys Leu Val Glu Phe Ser Lys Leu Pro Glu 
            20                  25                  30          


Gln Glu Arg Asn Tyr Asn Leu Gln Met Ser Leu Glu Thr Leu Lys 
        35                  40                  45          

<210>  1404
<211>  1573
<212>  DNA
<213>  Homo sapiens

<400>  1404
gagtcaggga aagccagaga cctctagaaa tgacaggaaa gtcaggaagt gggttcactg     60

cagggcctcc agaaggaact cagccctgtt gagcaatagg ttggtagata cttaagagta    120

tttttaaaag aaccaactaa ataaataaaa acaggtgatg atgagagtgt gtcacaaaca    180

aaagtttatc agtaatccac ggtccacttc tgtgtatttt gaaattcttc ttttgagaca    240

gagtcttact ctgtcaccca ggctggagtg cagtggcacg atctcagctc actgcaacct    300

ctacctcccg ggttcaagca attctcctcc ctcaacctcc caagtaactt ggattccagg    360

cacatgccac catgcctggc taatttttgt atttttaata gagacggggt ttcaccatgt    420

tagccaggct ggtggctggt cttgagctcc tgacctaagg tgatctgcct gctgtggcct    480

cccaaaagta gctgggatta caggcatgcg ccaccatgcc cggctaattt tgtattttta    540

gtacagacag ggtttcacca tttggtgagg ctggtctcga actcctgacc tcaggtgatc    600

cacctgcctc ggcctcccaa agtgctggga ttacaggcgt gagctgctgc actgggggaa    660

aatttacttc ttaaagcaca ctcatagggc aaatttccat gggtcaaaaa actattatta    720

atttaatagg aaaaaagtgc attcttgagc tcctatatta aacctaattt gtattaaaat    780

tatactaaat ctccctaaaa tgaagtcagt aattaattaa catgtcatat gctcacctaa    840

atgtattccc ttcttcactt gttcttcagt ttggttgtta acctgttcta ccaaagcttg    900

ttcttaacta tcacatagta taaactccag attcccttac agaatatatc ataccgaata    960

tgtacataat tcaaacttca gtgtaaggaa agcaaaacaa aaccagcaac aataaagttg   1020

gaaaaaaaca ataaagacaa aggaatgtca gtgaagaaac gcagatgata tctgatttac   1080

ccagcatatt gacggcatag ggaaaaccat gcacagagtc ttctctgatg tgaagcgtgt   1140

gcttgtctgc tgaaagaact taggcgctat gggctaattc ttacgactgt gaggaagact   1200

gcacatctca ctctgcttct gcttggctcc tccagagcca cgtgaaatca caacaattct   1260

tttttttttt ttttttgaga cggagttttg ctctcgttgc ccaggcttga gtgcaatggt   1320

gtgatcgcag ctcactggaa cctccacctc ccaggttcaa gggattctcc tgcttcaacc   1380

tcctgagtag ctgggattac aggcacacac cacgacgcct ggctaatttt ttgtattttt   1440

tgtagagatg gggttttacc atgttggcca ggctggtctc aaactcctga cctcagatga   1500

tccgcctgcc tcagcctcca aaggtgttgg gattacaggc gtgagccact gcgccaggcc   1560

ccaacaatgc ttt                                                      1573


<210>  1405
<211>  95
<212>  PRT
<213>  Homo sapiens

<400>  1405


Met Met Arg Val Cys His Lys Gln Lys Phe Ile Ser Asn Pro Arg Ser 
1               5                   10                  15      


Thr Ser Val Tyr Phe Glu Ile Leu Leu Leu Arg Gln Ser Leu Thr Leu 
            20                  25                  30          


Ser Pro Arg Leu Glu Cys Ser Gly Thr Ile Ser Ala His Cys Asn Leu 
        35                  40                  45              


Tyr Leu Pro Gly Ser Ser Asn Ser Pro Pro Ser Thr Ser Gln Val Thr 
    50                  55                  60                  


Trp Ile Pro Gly Thr Cys His His Ala Trp Leu Ile Phe Val Phe Leu 
65                  70                  75                  80  


Ile Glu Thr Gly Phe His His Val Ser Gln Ala Gly Gly Trp Ser 
                85                  90                  95  

<210>  1406
<211>  8541
<212>  DNA
<213>  Homo sapiens

<400>  1406
agttaccaag ctcggtgaag gagacaagtt cccacagctg actcggctcg gctctcccac     60

cttcccggca gcggccgcga gccctgattg tatccctcgc tttcctcgtg ggggagcacg    120

gactgacttg gctgaagaaa atgccagttc tgtggatgtg gccgtgacaa gaggacgtgc    180

ggctggaaga ggcagaaggg gacgaggaaa agcatgcttt gaagagaaga ataaaccagc    240

gaccccaacc ctttctgcaa attggtgcta ttacttgtgg gatccatttg ctttcattcc    300

ctcccacccc accgctgaag aaaccttgcc ctgagggctg agagccagcc ccctgcagcc    360

gggggacgct tctgggttgg aggaccttct ggatgtagcg tcggtggaac ctttagatac    420

tctcctctgg aaaagccacc atgaattcgg tagctgggaa taaagagagg cttgcggtct    480

ccaccagggg caagaaatac ggggtgaatg aagtctgctc gcccaccaag cccgcagcgc    540

ccttctcccc ggaaagctgg taccggaaag catacgagga gtcgcgcgcc ggcagccggc    600

ccactcctga gggcgcgggc tcagcgctcg gctcctcggg gaccccgtct cccggctcgg    660

gcacctcgtc cccgagctcg ttcaccggct ccccgggacc cgcctccccc ggcatcggca    720

ctagttcgcc gggctccttg ggcggctctc cgggcttcgg cacaggctcc ccgggctccg    780

gcagcggcgg cggctcctcc cccggctcgg accgcggcgt ctggtgcgag aactgcaacg    840

cccgcctggt ggagctcaag aggcaggccc tgaggttgct cctcccgggg cccttcccgg    900

gcaaggaccc tgctttctcg gctgtgattc acgacaaact ccaggtcccc aacaccatcc    960

ggaaggcatg gaacgaccgg gacaaccgct gtgacatttg cgccactcac ctgaaccagt   1020

tgaagcagga ggccatccag atggtgctga cgttggagca ggcagccggc agtgagcact   1080

acgacgcctc gccctgctcc ccgccaccgc tctccaacat ccccaccctg gtggggtccc   1140

ggcacgtggg tgggctccag cagcccagag actgggcctt tgtgcccgcc ccctgtgcca   1200

cctccaacta cacaggcttc gccaacaagc acggcagcaa acccagcagc cttggggtca   1260

gcaatggggc ggaaaagaag agcgggtccc caacccacca ggccaaggtc agcctccaga   1320

tggccaccag tccaagcaat gggaacatcc tcaattcggt ggccatccag gctcaccagt   1380

acctggatgg cacctggtcc ctgtcgagaa ccaacggggt caccctgtac ccataccaga   1440

tctcccagct gatgacagag agtagccggg agggactaac agaagcagtg ctgaaccgct   1500

acaatgcaga caagccttcc gcctgcagtg tcccagcctc gcagggctcc tgcgtggcca   1560

gcgagacttc cacaggcaca tcggtggccg cctccttctt tgcacgagct gcccagaagt   1620

taaatctgtc ttctaaaaag aagaaacatc ggccttccac ttcttccgct gccgaaccac   1680

cgctctttgc aaccagcttc agtgggattc tgcagacctc ccctccccca gccccaccct   1740

gcctgctgag ggctgtcaac aaggtgaagg acaccccggg gctgggcaag gtgaaagtca   1800

tgcttcgcat ctgttccacc ttggctcgag atacttcaga atccagctct ttcttaaagg   1860

tggacccacg gaagaagcag atcaccttgt acgatcccct gacttgtgga ggtcaaaatg   1920

ccttccaaaa gagaggcaac caggttcctc caaagatgtt tgccttcgat gcagtttttc   1980

cacaagacgc ttctcaggct gaagtgtgtg caggcaccgt ggcagaggtg atccagtctg   2040

tggtcaacgg ggcagatggc tgcgtgttct gtttcggcca cgccaaactg ggaaaatcct   2100

acaccatgat cggaaaggat gattccatgc agaacctggg catcattccc tgtgccatct   2160

cttggctctt caagctcata aacgaacgca aggaaaagac cggcgcccgt ttctcagtcc   2220

gggtttccgc cgtggaagtg tgggggaagg aggagaacct gcgggacctg ctgtcggagg   2280

tggccacggg cagcctgcag gacggccagt ccccgggcgt gtacctctgt gaggacccca   2340

tctgcggcac gcagctgcag aaccagagcg agctgcgggc ccccaccgca gagaaggctg   2400

cctttttcct ggatgccgcc attgcctccc gcaggagcca ccaacaggac tgtgatgagg   2460

acgaccaccg caactcacac gtgttcttca cactgcacat ctaccagtac cggatggaga   2520

agagcgggaa agggggaatg tctggaggtc gcagccgcct gcatctcatt gatctcggca   2580

gctgtgtgaa agctcttagc aaaaatcgag aaggaggctc agggctgtgt ctctcgctgt   2640

ctgctctggg caatgtcatc ctggctctcg tcaatggcag caaacacatt ccatacaaag   2700

agagcaagct cgccatgttg ctgcgggagt ctctggggaa catgaactgc cgtaccacca   2760

tgatcgcgca catctcggcc gcggtcggga gctacgcgga gaccctgtcc accatccaga   2820

ttgcatcgag agtcttgagg atgaagaaaa agaagacgaa gtacacatcc agctcgtccg   2880

gcggggagag ctcctgcgaa gaaggccgca tgcgcaggcc cacccagctg agacccttcc   2940

acaccagggc cacggtggac cctgacttcc ccatcgctca cctgtccagc gaccccgact   3000

actcctccag cagcgagcag tcctgcgaca ccgtcatcta catcgggccc aacggcacgg   3060

ccctctctga caaggagctc accgacaacg agggcccccc agactttgtc cctatcgtgc   3120

cagccctgca gaagacccgg ggcgacagcc ggcccgcaga ggcaggagag gctgcagccg   3180

gcaagtcaga aagggactgc ctgaagtgca acacgtttgc cgagctgcag gagaggctgg   3240

actgcatcga cggcagcgag gagcccagca gctttccttt cgaagaactg cctgctcagt   3300

ttgggccaga gcaggcaagc agaggccccc ggttaagcca agcagcgggg gcaagcccac   3360

tctctgagtc tgataaggaa gataatgggt ccgaaggtca gctgaccaac agagaaggcc   3420

ctgaactccc agcctccaag atgcagagga gtcactcacc tgtgcccgcc gcggcacccg   3480

cccacagccc cagcccggcc tcacccagga gcgtcccggg cagcagtagc cagcacagcg   3540

cctccccact cgtgcagagc cccagcctcc agagcagccg ggagagcctc aactcctgcg   3600

gcttcgtgga aggcaagccc aggcccatgg gctccccccg gctgggcatc gccagcctgt   3660

ccaagacctc ggagtacaag ccacccagct ctccttccca gagatgcaaa gtctacaccc   3720

agaagggggt cctgccgtct cccgccccac tgcctccctc gagcaaggat tccggcgtgg   3780

cgtctaggga gtccttgctg cagcccgagg tgcgtacgcc cccggttgga atgagccccc   3840

aggttttgaa aaaatccatg tctgctggga gcgaagggtt cccggaaact cctgtcgatg   3900

atgagcagca ggcagctact ccttcagagt ccaagaagga gatcctgagc accacgatgg   3960

tgacggtgca gcagccactg gagctgaacg gtgaggacga gctggtgttc acgctggtgg   4020

aggagctgac catcagcggg gtcctggaca gcggccgccc caccagcatc atcagcttca   4080

acagcgactg ctctgcacgg gccctggcct cgggctcgcg gcccgtcagc atcatcagca   4140

gcatcagcga ggacctggag tgctactcca gcacggcccc cgtctccgag gtcagcatca   4200

cacagttctt gcccctcccg aagatgagcc tggatgagaa ggcccaggac gcagggagca   4260

gacgctcttc catcagctcc tggctgagcg agatgagcgc gggcagtgag ggtgagcagt   4320

cgtgccacag tttcatagcc cagacgtgtt ttgggcacgg ggaggcaatg gcagaacctg   4380

tggcctcgga gtttgtcagc agcctccaga acaccgctgt ggtgtgcaga gagaagccca   4440

aggccagccc cgacaacttg ctcatcctgt ctgagatggg agatgactct ttcaacaaag   4500

cagcccccat caaaggctgc aaaatatcca cagtgagcaa ggccatggtc accatctcca   4560

acacggccaa tctgagcagc tgcgaggggt acatccccat gaagaccaat atcacagttt   4620

acccctgcat tgccatgagc ccccggaaca tccaagagcc ggaggccccc accgccaccc   4680

ccaaagcagg ccccacatta gcccagtccc gggagagtaa ggaaaacagt gcaaagaaag   4740

agatgaaatt tgaggacccg tggctgaaac gagaagagga agtgaaaaaa gagacggctc   4800

atcccaatga agaagggatg atgaggtgtg agactgccac gggcccctcg aatgctgaga   4860

ccagagcaga gcaggagcag gacggaaagc ccagtccggg agacaggctc agcagcagca   4920

gcggagaggt gtcggcctcc ccggtcactg acaacttcag gagggtcgtg gatgggtgtg   4980

agatggccct gcccggtttg gccacccaga gccccgtgca tcccaacaaa agcgtcaagt   5040

ccagcagcct tcccagggcc tttcagaagg ccagccggca ggaggagccg gacagcctct   5100

cctattactg cgctgctgag accaacgggg tgggtgcagc ctcgggcacc ccgccctcca   5160

aggctaccct ggaggggaag gtggcttccc ccaagcactg tgttctggct cggcccaaag   5220

ggactccccc tctgccccct gtccgaaagt ccagcctgga ccagaagaac cgggccagcc   5280

ctcagcacag tgccagcggc agcggcacca gcagccccct gaaccaacca gccgccttcc   5340

cggcgggcct cccagacgag cctagcggca agacgaagga cgccagcagc agcagcaagc   5400

tcttcagtgc caagctggag cagctggcca gcagaagcaa ctcgctgggc agggcgacag   5460

tcagccacta cgaatgcctc tccctggagc gggccgagag cctgtcctcc gtgagctccc   5520

ggctgcacgc gggcaaggac ggcaccatgc cccgcgcggg gaggagcctg ggccgcagcg   5580

ccgggacctc gccccccagc tccggggcct cgcccaaggc cggccagtcc aagatctccg   5640

ccgtgagcag actcctcctg gccagcccca gagcgcgcgg cccgtccgcc tccaccacca   5700

aaaccctcag cttctccacc aagtccctgc cgcaggcggt gggccagggc tccagctcgc   5760

cccccggtgg gaagcacacg ccctggtcca cgcagtccct cagcaggaac aggagctcgg   5820

gcctggcctc caagcttccc ctgcgggccg tcagcgggcg catctcggag ctgctgcagg   5880

gtggcgcggg cgcccggggc ttgcagctgc gggccgggcc cgaggcggag gcgcgcgggg   5940

gggccctggc cgaggacgag cccgcggccg cgcacctgct cccgtcgccc tacagcaaga   6000

tcacgccccc gcggaggccc caccgctgca gcagcggcca cggcagcgac aacagcagcg   6060

tgctgagcgg ggagctcccg ccggccatgg ggaagacggc cctgttctac cacagcggcg   6120

gcagcagcgg ctacgagagc gtgatgcggg acagcgaggc caccggcagc gcgtcctcgg   6180

cgcaggactc cacgagcgag aacagcagct ccgtgggcgg caggtgccgg agcctcaaga   6240

ccccgaagaa acgctccaat ccaggttctc agagacggag gcttatccca gcactatccc   6300

tggacacctc ttcccctgtg agaaaacccc ccaacagcac aggcgtccgc tgggtggatg   6360

gccccttgcg gagcagcccg aggggccttg gggaaccctt tgagattaaa gtctatgaaa   6420

tcgatgacgt ggagcgcctg cagcggcgac gagggggtgc cagcaaggag gccatgtgct   6480

tcaatgcaaa gctgaagatt ctggaacacc gccagcagag gatcgccgag gtccgcgcga   6540

agtacgagtg gctgatgaag gagctggagg cgaccaaaca gtatctgatg ctggatccca   6600

acaagtggct cagtgaattt gacttggagc aggtttggga gctggattcc ctggagtacc   6660

tggaggcact ggagtgtgtg acggagcgcc tggagagccg tgtcaacttc tgcaaggccc   6720

atctcatgat gatcacctgc ttcgacatca cctccaggcg ccggtagatg agccagaccc   6780

ttgtcctagt ggtcccccgc tccccaggac ttcagagatg ttgcacgccc ctaggccctc   6840

tgtgctgggg catcaaagac aatgaatgag gatgaaggtt ggtggcaagt ctggagcggg   6900

cgttgagcgg aaggcgagtt ttcttttgtt ttctgtagga aaggtgcaaa cgtcaaacac   6960

cgtggaagga gaaaaggatg ggaagcccga ggggtgtcca agccctgtga gactgaaaaa   7020

gcactttgag gaaccttaaa gaccttgttt gtacataaga actgctagca aaagagacct   7080

cactcttctc ttgctttcgt gagaaaggag gggcgtggat gtaggattgc tgtggaaagc   7140

gaacacaaaa caacccagaa tgactgatta agtgccttgc aaatctttat tattatccaa   7200

acatttatgt tcatactttc ttgtgtacag atggtgctag tcaagatgaa aacaacaaaa   7260

caaacaagaa aaacattttg gaaatgtatt cacagctctt tttctcttgg tgttttatcc   7320

tatttctgac ttgctgtttc taagtaagtt gtgtttgtag agctatttct taatcagtat   7380

tgcttatgaa taaatattac ctgtctttta tggttattct ggtgaggcca ctcaaacaga   7440

gagacttccc tcggcacgag ccagtgtgtg tgtttccaaa gtaggtttgg agcagcaggt   7500

gacctcgatg ccacatccca acaagcagcg tggtcaggta gacccagaag gttgattgtg   7560

gggcaggtgc tttagagaac aggtgaggag acggcacctg cagcacaggg gaggaggagt   7620

cctttgcgac ctgggccctc cctgctcctg ggaggtgggc cgtatgttct gtagaccgtt   7680

tgcccccctc aagtcctcca cacatgtggt tccttgaccc acaaatccac agtttgcgtg   7740

gccctcaaaa ttcatattca tttttattcc aaaaagtctt gaacgaaagc tggaaccaat   7800

tcaccagagc catatttctt tctttagtat tttctagtgt tgtgttgtag attgattaaa   7860

gtgggttttt ccccagctga gagaccttct caggcttgtt cagagacttc aactgtattg   7920

gattagaaga aggattcttg agactgtaca tcttgtctgt tgtccagagt acaaggattt   7980

cagctctcct gtgtcccaaa gcctctatgc caagaaggga caggcttgtc ctctcagtct   8040

ttgctcctgc ccaaaggcag agagagcttc ccctccataa ctcacacgac cctggatagg   8100

cagaacatag ctgaagacta tggatgtcca ggtcttggct cccaacaact caggacctca   8160

aattcagatg ttcctcccta taacaattcc cttaggaatt atgataccca ttttagtgat   8220

tgatagaaac ctggggtaca gagtggtcaa gggatttccc tgataaaagc tgtggtgctg   8280

atgatagtgc agcccagaat ctaagagtcc ctgcagcctt cgcatcgagg atggtactta   8340

ggcgtgtgca gagcacgctt cccttttgcc ctcaaatgca gcatatcttc atgagcctat   8400

ttatttccaa gctaggctgt ctttattaac caacaactca gccccagcca ctccccaagc   8460

ggggaaaaaa acactacgtt tcttggtcag tgtacctctg gacactgcag cccacacagc   8520

tggctgaact cggtaaatgg g                                             8541


<210>  1407
<211>  2108
<212>  PRT
<213>  Homo sapiens

<400>  1407


Met Asn Ser Val Ala Gly Asn Lys Glu Arg Leu Ala Val Ser Thr Arg 
1               5                   10                  15      


Gly Lys Lys Tyr Gly Val Asn Glu Val Cys Ser Pro Thr Lys Pro Ala 
            20                  25                  30          


Ala Pro Phe Ser Pro Glu Ser Trp Tyr Arg Lys Ala Tyr Glu Glu Ser 
        35                  40                  45              


Arg Ala Gly Ser Arg Pro Thr Pro Glu Gly Ala Gly Ser Ala Leu Gly 
    50                  55                  60                  


Ser Ser Gly Thr Pro Ser Pro Gly Ser Gly Thr Ser Ser Pro Ser Ser 
65                  70                  75                  80  


Phe Thr Gly Ser Pro Gly Pro Ala Ser Pro Gly Ile Gly Thr Ser Ser 
                85                  90                  95      


Pro Gly Ser Leu Gly Gly Ser Pro Gly Phe Gly Thr Gly Ser Pro Gly 
            100                 105                 110         


Ser Gly Ser Gly Gly Gly Ser Ser Pro Gly Ser Asp Arg Gly Val Trp 
        115                 120                 125             


Cys Glu Asn Cys Asn Ala Arg Leu Val Glu Leu Lys Arg Gln Ala Leu 
    130                 135                 140                 


Arg Leu Leu Leu Pro Gly Pro Phe Pro Gly Lys Asp Pro Ala Phe Ser 
145                 150                 155                 160 


Ala Val Ile His Asp Lys Leu Gln Val Pro Asn Thr Ile Arg Lys Ala 
                165                 170                 175     


Trp Asn Asp Arg Asp Asn Arg Cys Asp Ile Cys Ala Thr His Leu Asn 
            180                 185                 190         


Gln Leu Lys Gln Glu Ala Ile Gln Met Val Leu Thr Leu Glu Gln Ala 
        195                 200                 205             


Ala Gly Ser Glu His Tyr Asp Ala Ser Pro Cys Ser Pro Pro Pro Leu 
    210                 215                 220                 


Ser Asn Ile Pro Thr Leu Val Gly Ser Arg His Val Gly Gly Leu Gln 
225                 230                 235                 240 


Gln Pro Arg Asp Trp Ala Phe Val Pro Ala Pro Cys Ala Thr Ser Asn 
                245                 250                 255     


Tyr Thr Gly Phe Ala Asn Lys His Gly Ser Lys Pro Ser Ser Leu Gly 
            260                 265                 270         


Val Ser Asn Gly Ala Glu Lys Lys Ser Gly Ser Pro Thr His Gln Ala 
        275                 280                 285             


Lys Val Ser Leu Gln Met Ala Thr Ser Pro Ser Asn Gly Asn Ile Leu 
    290                 295                 300                 


Asn Ser Val Ala Ile Gln Ala His Gln Tyr Leu Asp Gly Thr Trp Ser 
305                 310                 315                 320 


Leu Ser Arg Thr Asn Gly Val Thr Leu Tyr Pro Tyr Gln Ile Ser Gln 
                325                 330                 335     


Leu Met Thr Glu Ser Ser Arg Glu Gly Leu Thr Glu Ala Val Leu Asn 
            340                 345                 350         


Arg Tyr Asn Ala Asp Lys Pro Ser Ala Cys Ser Val Pro Ala Ser Gln 
        355                 360                 365             


Gly Ser Cys Val Ala Ser Glu Thr Ser Thr Gly Thr Ser Val Ala Ala 
    370                 375                 380                 


Ser Phe Phe Ala Arg Ala Ala Gln Lys Leu Asn Leu Ser Ser Lys Lys 
385                 390                 395                 400 


Lys Lys His Arg Pro Ser Thr Ser Ser Ala Ala Glu Pro Pro Leu Phe 
                405                 410                 415     


Ala Thr Ser Phe Ser Gly Ile Leu Gln Thr Ser Pro Pro Pro Ala Pro 
            420                 425                 430         


Pro Cys Leu Leu Arg Ala Val Asn Lys Val Lys Asp Thr Pro Gly Leu 
        435                 440                 445             


Gly Lys Val Lys Val Met Leu Arg Ile Cys Ser Thr Leu Ala Arg Asp 
    450                 455                 460                 


Thr Ser Glu Ser Ser Ser Phe Leu Lys Val Asp Pro Arg Lys Lys Gln 
465                 470                 475                 480 


Ile Thr Leu Tyr Asp Pro Leu Thr Cys Gly Gly Gln Asn Ala Phe Gln 
                485                 490                 495     


Lys Arg Gly Asn Gln Val Pro Pro Lys Met Phe Ala Phe Asp Ala Val 
            500                 505                 510         


Phe Pro Gln Asp Ala Ser Gln Ala Glu Val Cys Ala Gly Thr Val Ala 
        515                 520                 525             


Glu Val Ile Gln Ser Val Val Asn Gly Ala Asp Gly Cys Val Phe Cys 
    530                 535                 540                 


Phe Gly His Ala Lys Leu Gly Lys Ser Tyr Thr Met Ile Gly Lys Asp 
545                 550                 555                 560 


Asp Ser Met Gln Asn Leu Gly Ile Ile Pro Cys Ala Ile Ser Trp Leu 
                565                 570                 575     


Phe Lys Leu Ile Asn Glu Arg Lys Glu Lys Thr Gly Ala Arg Phe Ser 
            580                 585                 590         


Val Arg Val Ser Ala Val Glu Val Trp Gly Lys Glu Glu Asn Leu Arg 
        595                 600                 605             


Asp Leu Leu Ser Glu Val Ala Thr Gly Ser Leu Gln Asp Gly Gln Ser 
    610                 615                 620                 


Pro Gly Val Tyr Leu Cys Glu Asp Pro Ile Cys Gly Thr Gln Leu Gln 
625                 630                 635                 640 


Asn Gln Ser Glu Leu Arg Ala Pro Thr Ala Glu Lys Ala Ala Phe Phe 
                645                 650                 655     


Leu Asp Ala Ala Ile Ala Ser Arg Arg Ser His Gln Gln Asp Cys Asp 
            660                 665                 670         


Glu Asp Asp His Arg Asn Ser His Val Phe Phe Thr Leu His Ile Tyr 
        675                 680                 685             


Gln Tyr Arg Met Glu Lys Ser Gly Lys Gly Gly Met Ser Gly Gly Arg 
    690                 695                 700                 


Ser Arg Leu His Leu Ile Asp Leu Gly Ser Cys Val Lys Ala Leu Ser 
705                 710                 715                 720 


Lys Asn Arg Glu Gly Gly Ser Gly Leu Cys Leu Ser Leu Ser Ala Leu 
                725                 730                 735     


Gly Asn Val Ile Leu Ala Leu Val Asn Gly Ser Lys His Ile Pro Tyr 
            740                 745                 750         


Lys Glu Ser Lys Leu Ala Met Leu Leu Arg Glu Ser Leu Gly Asn Met 
        755                 760                 765             


Asn Cys Arg Thr Thr Met Ile Ala His Ile Ser Ala Ala Val Gly Ser 
    770                 775                 780                 


Tyr Ala Glu Thr Leu Ser Thr Ile Gln Ile Ala Ser Arg Val Leu Arg 
785                 790                 795                 800 


Met Lys Lys Lys Lys Thr Lys Tyr Thr Ser Ser Ser Ser Gly Gly Glu 
                805                 810                 815     


Ser Ser Cys Glu Glu Gly Arg Met Arg Arg Pro Thr Gln Leu Arg Pro 
            820                 825                 830         


Phe His Thr Arg Ala Thr Val Asp Pro Asp Phe Pro Ile Ala His Leu 
        835                 840                 845             


Ser Ser Asp Pro Asp Tyr Ser Ser Ser Ser Glu Gln Ser Cys Asp Thr 
    850                 855                 860                 


Val Ile Tyr Ile Gly Pro Asn Gly Thr Ala Leu Ser Asp Lys Glu Leu 
865                 870                 875                 880 


Thr Asp Asn Glu Gly Pro Pro Asp Phe Val Pro Ile Val Pro Ala Leu 
                885                 890                 895     


Gln Lys Thr Arg Gly Asp Ser Arg Pro Ala Glu Ala Gly Glu Ala Ala 
            900                 905                 910         


Ala Gly Lys Ser Glu Arg Asp Cys Leu Lys Cys Asn Thr Phe Ala Glu 
        915                 920                 925             


Leu Gln Glu Arg Leu Asp Cys Ile Asp Gly Ser Glu Glu Pro Ser Ser 
    930                 935                 940                 


Phe Pro Phe Glu Glu Leu Pro Ala Gln Phe Gly Pro Glu Gln Ala Ser 
945                 950                 955                 960 


Arg Gly Pro Arg Leu Ser Gln Ala Ala Gly Ala Ser Pro Leu Ser Glu 
                965                 970                 975     


Ser Asp Lys Glu Asp Asn Gly Ser Glu Gly Gln Leu Thr Asn Arg Glu 
            980                 985                 990         


Gly Pro Glu Leu Pro Ala Ser Lys  Met Gln Arg Ser His  Ser Pro Val 
        995                 1000                 1005             


Pro Ala  Ala Ala Pro Ala His  Ser Pro Ser Pro Ala  Ser Pro Arg 
    1010                 1015                 1020             


Ser Val  Pro Gly Ser Ser Ser  Gln His Ser Ala Ser  Pro Leu Val 
    1025                 1030                 1035             


Gln Ser  Pro Ser Leu Gln Ser  Ser Arg Glu Ser Leu  Asn Ser Cys 
    1040                 1045                 1050             


Gly Phe  Val Glu Gly Lys Pro  Arg Pro Met Gly Ser  Pro Arg Leu 
    1055                 1060                 1065             


Gly Ile  Ala Ser Leu Ser Lys  Thr Ser Glu Tyr Lys  Pro Pro Ser 
    1070                 1075                 1080             


Ser Pro  Ser Gln Arg Cys Lys  Val Tyr Thr Gln Lys  Gly Val Leu 
    1085                 1090                 1095             


Pro Ser  Pro Ala Pro Leu Pro  Pro Ser Ser Lys Asp  Ser Gly Val 
    1100                 1105                 1110             


Ala Ser  Arg Glu Ser Leu Leu  Gln Pro Glu Val Arg  Thr Pro Pro 
    1115                 1120                 1125             


Val Gly  Met Ser Pro Gln Val  Leu Lys Lys Ser Met  Ser Ala Gly 
    1130                 1135                 1140             


Ser Glu  Gly Phe Pro Glu Thr  Pro Val Asp Asp Glu  Gln Gln Ala 
    1145                 1150                 1155             


Ala Thr  Pro Ser Glu Ser Lys  Lys Glu Ile Leu Ser  Thr Thr Met 
    1160                 1165                 1170             


Val Thr  Val Gln Gln Pro Leu  Glu Leu Asn Gly Glu  Asp Glu Leu 
    1175                 1180                 1185             


Val Phe  Thr Leu Val Glu Glu  Leu Thr Ile Ser Gly  Val Leu Asp 
    1190                 1195                 1200             


Ser Gly  Arg Pro Thr Ser Ile  Ile Ser Phe Asn Ser  Asp Cys Ser 
    1205                 1210                 1215             


Ala Arg  Ala Leu Ala Ser Gly  Ser Arg Pro Val Ser  Ile Ile Ser 
    1220                 1225                 1230             


Ser Ile  Ser Glu Asp Leu Glu  Cys Tyr Ser Ser Thr  Ala Pro Val 
    1235                 1240                 1245             


Ser Glu  Val Ser Ile Thr Gln  Phe Leu Pro Leu Pro  Lys Met Ser 
    1250                 1255                 1260             


Leu Asp  Glu Lys Ala Gln Asp  Ala Gly Ser Arg Arg  Ser Ser Ile 
    1265                 1270                 1275             


Ser Ser  Trp Leu Ser Glu Met  Ser Ala Gly Ser Glu  Gly Glu Gln 
    1280                 1285                 1290             


Ser Cys  His Ser Phe Ile Ala  Gln Thr Cys Phe Gly  His Gly Glu 
    1295                 1300                 1305             


Ala Met  Ala Glu Pro Val Ala  Ser Glu Phe Val Ser  Ser Leu Gln 
    1310                 1315                 1320             


Asn Thr  Ala Val Val Cys Arg  Glu Lys Pro Lys Ala  Ser Pro Asp 
    1325                 1330                 1335             


Asn Leu  Leu Ile Leu Ser Glu  Met Gly Asp Asp Ser  Phe Asn Lys 
    1340                 1345                 1350             


Ala Ala  Pro Ile Lys Gly Cys  Lys Ile Ser Thr Val  Ser Lys Ala 
    1355                 1360                 1365             


Met Val  Thr Ile Ser Asn Thr  Ala Asn Leu Ser Ser  Cys Glu Gly 
    1370                 1375                 1380             


Tyr Ile  Pro Met Lys Thr Asn  Ile Thr Val Tyr Pro  Cys Ile Ala 
    1385                 1390                 1395             


Met Ser  Pro Arg Asn Ile Gln  Glu Pro Glu Ala Pro  Thr Ala Thr 
    1400                 1405                 1410             


Pro Lys  Ala Gly Pro Thr Leu  Ala Gln Ser Arg Glu  Ser Lys Glu 
    1415                 1420                 1425             


Asn Ser  Ala Lys Lys Glu Met  Lys Phe Glu Asp Pro  Trp Leu Lys 
    1430                 1435                 1440             


Arg Glu  Glu Glu Val Lys Lys  Glu Thr Ala His Pro  Asn Glu Glu 
    1445                 1450                 1455             


Gly Met  Met Arg Cys Glu Thr  Ala Thr Gly Pro Ser  Asn Ala Glu 
    1460                 1465                 1470             


Thr Arg  Ala Glu Gln Glu Gln  Asp Gly Lys Pro Ser  Pro Gly Asp 
    1475                 1480                 1485             


Arg Leu  Ser Ser Ser Ser Gly  Glu Val Ser Ala Ser  Pro Val Thr 
    1490                 1495                 1500             


Asp Asn  Phe Arg Arg Val Val  Asp Gly Cys Glu Met  Ala Leu Pro 
    1505                 1510                 1515             


Gly Leu  Ala Thr Gln Ser Pro  Val His Pro Asn Lys  Ser Val Lys 
    1520                 1525                 1530             


Ser Ser  Ser Leu Pro Arg Ala  Phe Gln Lys Ala Ser  Arg Gln Glu 
    1535                 1540                 1545             


Glu Pro  Asp Ser Leu Ser Tyr  Tyr Cys Ala Ala Glu  Thr Asn Gly 
    1550                 1555                 1560             


Val Gly  Ala Ala Ser Gly Thr  Pro Pro Ser Lys Ala  Thr Leu Glu 
    1565                 1570                 1575             


Gly Lys  Val Ala Ser Pro Lys  His Cys Val Leu Ala  Arg Pro Lys 
    1580                 1585                 1590             


Gly Thr  Pro Pro Leu Pro Pro  Val Arg Lys Ser Ser  Leu Asp Gln 
    1595                 1600                 1605             


Lys Asn  Arg Ala Ser Pro Gln  His Ser Ala Ser Gly  Ser Gly Thr 
    1610                 1615                 1620             


Ser Ser  Pro Leu Asn Gln Pro  Ala Ala Phe Pro Ala  Gly Leu Pro 
    1625                 1630                 1635             


Asp Glu  Pro Ser Gly Lys Thr  Lys Asp Ala Ser Ser  Ser Ser Lys 
    1640                 1645                 1650             


Leu Phe  Ser Ala Lys Leu Glu  Gln Leu Ala Ser Arg  Ser Asn Ser 
    1655                 1660                 1665             


Leu Gly  Arg Ala Thr Val Ser  His Tyr Glu Cys Leu  Ser Leu Glu 
    1670                 1675                 1680             


Arg Ala  Glu Ser Leu Ser Ser  Val Ser Ser Arg Leu  His Ala Gly 
    1685                 1690                 1695             


Lys Asp  Gly Thr Met Pro Arg  Ala Gly Arg Ser Leu  Gly Arg Ser 
    1700                 1705                 1710             


Ala Gly  Thr Ser Pro Pro Ser  Ser Gly Ala Ser Pro  Lys Ala Gly 
    1715                 1720                 1725             


Gln Ser  Lys Ile Ser Ala Val  Ser Arg Leu Leu Leu  Ala Ser Pro 
    1730                 1735                 1740             


Arg Ala  Arg Gly Pro Ser Ala  Ser Thr Thr Lys Thr  Leu Ser Phe 
    1745                 1750                 1755             


Ser Thr  Lys Ser Leu Pro Gln  Ala Val Gly Gln Gly  Ser Ser Ser 
    1760                 1765                 1770             


Pro Pro  Gly Gly Lys His Thr  Pro Trp Ser Thr Gln  Ser Leu Ser 
    1775                 1780                 1785             


Arg Asn  Arg Ser Ser Gly Leu  Ala Ser Lys Leu Pro  Leu Arg Ala 
    1790                 1795                 1800             


Val Ser  Gly Arg Ile Ser Glu  Leu Leu Gln Gly Gly  Ala Gly Ala 
    1805                 1810                 1815             


Arg Gly  Leu Gln Leu Arg Ala  Gly Pro Glu Ala Glu  Ala Arg Gly 
    1820                 1825                 1830             


Gly Ala  Leu Ala Glu Asp Glu  Pro Ala Ala Ala His  Leu Leu Pro 
    1835                 1840                 1845             


Ser Pro  Tyr Ser Lys Ile Thr  Pro Pro Arg Arg Pro  His Arg Cys 
    1850                 1855                 1860             


Ser Ser  Gly His Gly Ser Asp  Asn Ser Ser Val Leu  Ser Gly Glu 
    1865                 1870                 1875             


Leu Pro  Pro Ala Met Gly Lys  Thr Ala Leu Phe Tyr  His Ser Gly 
    1880                 1885                 1890             


Gly Ser  Ser Gly Tyr Glu Ser  Val Met Arg Asp Ser  Glu Ala Thr 
    1895                 1900                 1905             


Gly Ser  Ala Ser Ser Ala Gln  Asp Ser Thr Ser Glu  Asn Ser Ser 
    1910                 1915                 1920             


Ser Val  Gly Gly Arg Cys Arg  Ser Leu Lys Thr Pro  Lys Lys Arg 
    1925                 1930                 1935             


Ser Asn  Pro Gly Ser Gln Arg  Arg Arg Leu Ile Pro  Ala Leu Ser 
    1940                 1945                 1950             


Leu Asp  Thr Ser Ser Pro Val  Arg Lys Pro Pro Asn  Ser Thr Gly 
    1955                 1960                 1965             


Val Arg  Trp Val Asp Gly Pro  Leu Arg Ser Ser Pro  Arg Gly Leu 
    1970                 1975                 1980             


Gly Glu  Pro Phe Glu Ile Lys  Val Tyr Glu Ile Asp  Asp Val Glu 
    1985                 1990                 1995             


Arg Leu  Gln Arg Arg Arg Gly  Gly Ala Ser Lys Glu  Ala Met Cys 
    2000                 2005                 2010             


Phe Asn  Ala Lys Leu Lys Ile  Leu Glu His Arg Gln  Gln Arg Ile 
    2015                 2020                 2025             


Ala Glu  Val Arg Ala Lys Tyr  Glu Trp Leu Met Lys  Glu Leu Glu 
    2030                 2035                 2040             


Ala Thr  Lys Gln Tyr Leu Met  Leu Asp Pro Asn Lys  Trp Leu Ser 
    2045                 2050                 2055             


Glu Phe  Asp Leu Glu Gln Val  Trp Glu Leu Asp Ser  Leu Glu Tyr 
    2060                 2065                 2070             


Leu Glu  Ala Leu Glu Cys Val  Thr Glu Arg Leu Glu  Ser Arg Val 
    2075                 2080                 2085             


Asn Phe  Cys Lys Ala His Leu  Met Met Ile Thr Cys  Phe Asp Ile 
    2090                 2095                 2100             


Thr Ser  Arg Arg Arg 
    2105             

<210>  1408
<211>  3994
<212>  DNA
<213>  Homo sapiens

<400>  1408
agttaccaag ctcggtgaag gagacaagtt cccacagctg actcggctcg gctctcccac     60

cttcccggca gcggccgcga gccctgattg tatccctcgc tttcctcgtg ggggagcacg    120

gactgacttg gctgaagaaa atgccagttc tgtggatgtg gccgtgacaa gaggacgtgc    180

ggctggaaga ggcagaaggg gacgaggaaa agcatgcttt gaagagaaga ataaaccagc    240

gaccccaacc ctttctgcaa attggtgcta ttacttgtgg gatccatttg ctttcattcc    300

ctcccacccc accgctgaag aaaccttgcc ctgagggctg agagccagcc ccctgcagcc    360

gggggacgct tctgggttgg aggaccttct ggatgtagcg tcggtggaac ctttagatac    420

tctcctctgg aaaagccacc atgaattcgg tagctgggaa taaagagagg cttgcggtct    480

ccaccagggg caagaaatac ggggtgaatg aagtctgctc gcccaccaag cccgcagcgc    540

ccttctcccc ggaaagctgg taccggaaag catacgagga gtcgcgcgcc ggcagccggc    600

ccactcctga gggcgcgggc tcagcgctcg gctcctcggg gaccccgtct cccggctcgg    660

gcacctcgtc cccgagctcg ttcaccggct ccccgggacc cgcctccccc ggcatcggca    720

ctagttcgcc gggctccttg ggcggctctc cgggcttcgg cacaggctcc ccgggctccg    780

gcagcggcgg cggctcctcc cccggctcgg accgcggcgt ctggtgcgag aactgcaacg    840

cccgcctggt ggagctcaag aggcaggccc tgaggttgct cctcccgggg cccttcccgg    900

gcaaggaccc tgctttctcg gctgtgattc acgacaaact ccaggtcccc aacaccatcc    960

ggaaggcatg gaacgaccgg gacaaccgct gtgacatttg cgccactcac ctgaaccagt   1020

tgaagcagga ggccatccag atggtgctga cgttggagca ggcagccggc agtgagcact   1080

acgacgcctc gccctgctcc ccgccaccgc tctccaacat ccccaccctg gtggggtccc   1140

ggcacgtggg tgggctccag cagcccagag actgggcctt tgtgcccgcc ccctgtgcca   1200

cctccaacta cacaggcttc gccaacaagc acggcagcaa acccagcagc cttggggtca   1260

gcaatggggc ggaaaagaag agcgggtccc caacccacca ggccaaggtc agcctccaga   1320

tggccaccag tccaagcaat gggaacatcc tcaattcggt ggccatccag gctcaccagt   1380

acctggatgg cacctggtcc ctgtcgagaa ccaacggggt caccctgtac ccataccaga   1440

tctcccagct gatgacagag agtagccggg agggactaac agaagcacgg ccacggcagc   1500

gacaacagca gcgtgctgag cggggagctc ccgccggcca tggggaagac ggccctgttc   1560

taccacagcg gcggcagcag cggctacgag agcgtgatgc gggacagcga ggccaccggc   1620

agcgcgtcct cggcgcagga ctccacgagc gagaacagca gctccgtggg cggcaggtgc   1680

cggagcctca agaccccgaa gaaacgctcc aatccaggtt ctcagagacg gaggcttatc   1740

ccagcactat ccctggacac ctcttcccct gtgagaaaac cccccaacag cacaggcgtc   1800

cgctgggtgg atggcccctt gcggagcagc ccgaggggcc ttggggaacc ctttgagatt   1860

aaagtctatg aaatcgatga cgtggagcgc ctgcagcggc gacgaggggg tgccagcaag   1920

gaggccatgt gcttcaatgc aaagctgaag attctggaac accgccagca gaggatcgcc   1980

gaggtccgcg cgaagtacga gtggctgatg aaggagctgg aggcgaccaa acagtatctg   2040

atgctggatc ccaacaagtg gctcagtgaa tttgacttgg agcaggtttg ggagctggat   2100

tccctggagt acctggaggc actggagtgt gtgacggagc gcctggagag ccgtgtcaac   2160

ttctgcaagg cccatctcat gatgatcacc tgcttcgaca tcacctccag gcgccggtag   2220

atgagccaga cccttgtcct agtggtcccc cgctccccag gacttcagag atgttgcacg   2280

cccctaggcc ctctgtgctg gggcatcaaa gacaatgaat gaggatgaag gttggtggca   2340

agtctggagc gggcgttgag cggaaggcga gttttctttt gttttctgta ggaaaggtgc   2400

aaacgtcaaa caccgtggaa ggagaaaagg atgggaagcc cgaggggtgt ccaagccctg   2460

tgagactgaa aaagcacttt gaggaacctt aaagaccttg tttgtacata agaactgcta   2520

gcaaaagaga cctcactctt ctcttgcttt cgtgagaaag gaggggcgtg gatgtaggat   2580

tgctgtggaa agcgaacaca aaacaaccca gaatgactga ttaagtgcct tgcaaatctt   2640

tattattatc caaacattta tgttcatact ttcttgtgta cagatggtgc tagtcaagat   2700

gaaaacaaca aaacaaacaa gaaaaacatt ttggaaatgt attcacagct ctttttctct   2760

tggtgtttta tcctatttct gacttgctgt ttctaagtaa gttgtgtttg tagagctatt   2820

tcttaatcag tattgcttat gaataaatat tacctgtctt ttatggttat tctggtgagg   2880

ccactcaaac agagagactt ccctcggcac gagccagtgt gtgtgtttcc aaagtaggtt   2940

tggagcagca ggtgacctcg atgccacatc ccaacaagca gcgtggtcag gtagacccag   3000

aaggttgatt gtggggcagg tgctttagag aacaggtgag gagacggcac ctgcagcaca   3060

ggggaggagg agtcctttgc gacctgggcc ctccctgctc ctgggaggtg ggccgtatgt   3120

tctgtagacc gtttgccccc ctcaagtcct ccacacatgt ggttccttga cccacaaatc   3180

cacagtttgc gtggccctca aaattcatat tcatttttat tccaaaaagt cttgaacgaa   3240

agctggaacc aattcaccag agccatattt ctttctttag tattttctag tgttgtgttg   3300

tagattgatt aaagtgggtt tttccccagc tgagagacct tctcaggctt gttcagagac   3360

ttcaactgta ttggattaga agaaggattc ttgagactgt acatcttgtc tgttgtccag   3420

agtacaagga tttcagctct cctgtgtccc aaagcctcta tgccaagaag ggacaggctt   3480

gtcctctcag tctttgctcc tgcccaaagg cagagagagc ttcccctcca taactcacac   3540

gaccctggat aggcagaaca tagctgaaga ctatggatgt ccaggtcttg gctcccaaca   3600

actcaggacc tcaaattcag atgttcctcc ctataacaat tcccttagga attatgatac   3660

ccattttagt gattgataga aacctggggt acagagtggt caagggattt ccctgataaa   3720

agctgtggtg ctgatgatag tgcagcccag aatctaagag tccctgcagc cttcgcatcg   3780

aggatggtac ttaggcgtgt gcagagcacg cttccctttt gccctcaaat gcagcatatc   3840

ttcatgagcc tatttatttc caagctaggc tgtctttatt aaccaacaac tcagccccag   3900

ccactcccca agcggggaaa aaaacactac gtttcttggt cagtgtacct ctggacactg   3960

cagcccacac agctggctga actcggtaaa tggg                               3994


<210>  1409
<211>  471
<212>  PRT
<213>  Homo sapiens

<400>  1409


Met Asn Ser Val Ala Gly Asn Lys Glu Arg Leu Ala Val Ser Thr Arg 
1               5                   10                  15      


Gly Lys Lys Tyr Gly Val Asn Glu Val Cys Ser Pro Thr Lys Pro Ala 
            20                  25                  30          


Ala Pro Phe Ser Pro Glu Ser Trp Tyr Arg Lys Ala Tyr Glu Glu Ser 
        35                  40                  45              


Arg Ala Gly Ser Arg Pro Thr Pro Glu Gly Ala Gly Ser Ala Leu Gly 
    50                  55                  60                  


Ser Ser Gly Thr Pro Ser Pro Gly Ser Gly Thr Ser Ser Pro Ser Ser 
65                  70                  75                  80  


Phe Thr Gly Ser Pro Gly Pro Ala Ser Pro Gly Ile Gly Thr Ser Ser 
                85                  90                  95      


Pro Gly Ser Leu Gly Gly Ser Pro Gly Phe Gly Thr Gly Ser Pro Gly 
            100                 105                 110         


Ser Gly Ser Gly Gly Gly Ser Ser Pro Gly Ser Asp Arg Gly Val Trp 
        115                 120                 125             


Cys Glu Asn Cys Asn Ala Arg Leu Val Glu Leu Lys Arg Gln Ala Leu 
    130                 135                 140                 


Arg Leu Leu Leu Pro Gly Pro Phe Pro Gly Lys Asp Pro Ala Phe Ser 
145                 150                 155                 160 


Ala Val Ile His Asp Lys Leu Gln Val Pro Asn Thr Ile Arg Lys Ala 
                165                 170                 175     


Trp Asn Asp Arg Asp Asn Arg Cys Asp Ile Cys Ala Thr His Leu Asn 
            180                 185                 190         


Gln Leu Lys Gln Glu Ala Ile Gln Met Val Leu Thr Leu Glu Gln Ala 
        195                 200                 205             


Ala Gly Ser Glu His Tyr Asp Ala Ser Pro Cys Ser Pro Pro Pro Leu 
    210                 215                 220                 


Ser Asn Ile Pro Thr Leu Val Gly Ser Arg His Val Gly Gly Leu Gln 
225                 230                 235                 240 


Gln Pro Arg Asp Trp Ala Phe Val Pro Ala Pro Cys Ala Thr Ser Asn 
                245                 250                 255     


Tyr Thr Gly Phe Ala Asn Lys His Gly Ser Lys Pro Ser Ser Leu Gly 
            260                 265                 270         


Val Ser Asn Gly Ala Glu Lys Lys Ser Gly Ser Pro Thr His Gln Ala 
        275                 280                 285             


Lys Val Ser Leu Gln Met Ala Thr Ser Pro Ser Asn Gly Asn Ile Leu 
    290                 295                 300                 


Asn Ser Val Ala Ile Gln Ala His Gln Tyr Leu Asp Gly Thr Trp Ser 
305                 310                 315                 320 


Leu Ser Arg Thr Asn Gly Val Thr Leu Tyr Pro Tyr Gln Ile Ser Gln 
                325                 330                 335     


Leu Met Thr Glu Ser Ser Arg Glu Gly Leu Thr Glu Ala Arg Pro Arg 
            340                 345                 350         


Gln Arg Gln Gln Gln Arg Ala Glu Arg Gly Ala Pro Ala Gly His Gly 
        355                 360                 365             


Glu Asp Gly Pro Val Leu Pro Gln Arg Arg Gln Gln Arg Leu Arg Glu 
    370                 375                 380                 


Arg Asp Ala Gly Gln Arg Gly His Arg Gln Arg Val Leu Gly Ala Gly 
385                 390                 395                 400 


Leu His Glu Arg Glu Gln Gln Leu Arg Gly Arg Gln Val Pro Glu Pro 
                405                 410                 415     


Gln Asp Pro Glu Glu Thr Leu Gln Ser Arg Phe Ser Glu Thr Glu Ala 
            420                 425                 430         


Tyr Pro Ser Thr Ile Pro Gly His Leu Phe Pro Cys Glu Lys Thr Pro 
        435                 440                 445             


Gln Gln His Arg Arg Pro Leu Gly Gly Trp Pro Leu Ala Glu Gln Pro 
    450                 455                 460                 


Glu Gly Pro Trp Gly Thr Leu 
465                 470     

<210>  1410
<211>  1693
<212>  DNA
<213>  Homo sapiens

<400>  1410
acggagggcg caggacccag ggcgctgaac tctcacaacc aatcaggcga cccccccaga     60

gggaaactac aagtcccagc atgccccacg cgcaccgtca ggggccgacc cgccgcgccc    120

cagcgttctc cgcgtacagg tggtctcttg ggttccggta aggcggcggc tgcggaactc    180

ccgtggaggg gccggtgggc cctcgggcct gacgatggca gtggccactg cggcggcagt    240

actggccgct ctgggcgggg cgctgtggct ggcggcccgc cggttcgtgg ggcccagggt    300

ccagcggctg cgcagaggcg gggaccccgg cctcatgcac gggaagactg tgctgatcac    360

cggggcgaac agcggcctgg gccgcgccac ggccgccgag ctactgcgcc tgggagcgcg    420

ggtgatcatg ggctgccggg accgcgcgcg cgccgaggag gcggcgggtc agctccgccg    480

cgagctccgc caggccgcgg agtgcggccc agagcctggc gtcagcgggg tgggcgagct    540

catagtccgg gagctggacc tcgcctcgct gcgctcggtg cgcgccttct gccaggaaat    600

gctccaggaa gagcctaggc tggatgtctt gatcaataac gcagggatct tccagtgccc    660

ttacatgaag actgaagatg ggtttgagat gcagttcgga gtgaaccatc tggggcactt    720

tctactcacc aatcttctcc ttggactcct caaaagttca gctcccagca ggattgtggt    780

agtttcttcc aaactttata aatacggaga catcaatttt gatgacttga acagtgaaca    840

aagctataat aaaagctttt gttatagccg gagcaaactg gctaacattc tttttaccag    900

ggaactagcc cgccgcttag aaggcacaaa tgtcaccgtc aatgtgttgc atcctggtat    960

tgtacggaca aatctgggga ggcacataca cattccactg ttggtcaaac cactcttcaa   1020

tttggtgtca tgggcttttt tcaaaactcc agtagaaggt gcccagactt ccatttattt   1080

ggcctcttca cctgaggtag aaggagtgtc aggaagatac tttggggatt gtaaagagga   1140

agaactgttg cccaaagcta tggatgaatc tgttgcaaga aaactctggg atatcagtga   1200

agtgatggtt ggcctgctaa aataggaaca aggagtaaaa gagctgttta taaaactgca   1260

tatcagttat atctgtgatc aggaatggtg tggattgaga acttgttact tgaagaaaaa   1320

gaattttgat attggaatag cctgctaaga ggtacatgtg ggtattttgg agttactgaa   1380

aaattatttt tgggataaga gaatttcagc aaagatgttt taaatatata tagtaagtat   1440

aatgaataat aagtacaatg aaaaatacaa ttatattgta aaattataac tgggcaagca   1500

tggatgacat attaatattt gtcagaatta agtgactcaa agtgctatcg agaggttttt   1560

caagtatctt tgagtttcat ggccaaagtg ttaactagtt ttactacaat gtttggtgtt   1620

tgtgtggaaa ttatctgcct ggtgtgtgca cacaagtctt acttggaata aatttactgg   1680

tacaaattct taa                                                      1693


<210>  1411
<211>  336
<212>  PRT
<213>  Homo sapiens

<400>  1411


Met Ala Val Ala Thr Ala Ala Ala Val Leu Ala Ala Leu Gly Gly Ala 
1               5                   10                  15      


Leu Trp Leu Ala Ala Arg Arg Phe Val Gly Pro Arg Val Gln Arg Leu 
            20                  25                  30          


Arg Arg Gly Gly Asp Pro Gly Leu Met His Gly Lys Thr Val Leu Ile 
        35                  40                  45              


Thr Gly Ala Asn Ser Gly Leu Gly Arg Ala Thr Ala Ala Glu Leu Leu 
    50                  55                  60                  


Arg Leu Gly Ala Arg Val Ile Met Gly Cys Arg Asp Arg Ala Arg Ala 
65                  70                  75                  80  


Glu Glu Ala Ala Gly Gln Leu Arg Arg Glu Leu Arg Gln Ala Ala Glu 
                85                  90                  95      


Cys Gly Pro Glu Pro Gly Val Ser Gly Val Gly Glu Leu Ile Val Arg 
            100                 105                 110         


Glu Leu Asp Leu Ala Ser Leu Arg Ser Val Arg Ala Phe Cys Gln Glu 
        115                 120                 125             


Met Leu Gln Glu Glu Pro Arg Leu Asp Val Leu Ile Asn Asn Ala Gly 
    130                 135                 140                 


Ile Phe Gln Cys Pro Tyr Met Lys Thr Glu Asp Gly Phe Glu Met Gln 
145                 150                 155                 160 


Phe Gly Val Asn His Leu Gly His Phe Leu Leu Thr Asn Leu Leu Leu 
                165                 170                 175     


Gly Leu Leu Lys Ser Ser Ala Pro Ser Arg Ile Val Val Val Ser Ser 
            180                 185                 190         


Lys Leu Tyr Lys Tyr Gly Asp Ile Asn Phe Asp Asp Leu Asn Ser Glu 
        195                 200                 205             


Gln Ser Tyr Asn Lys Ser Phe Cys Tyr Ser Arg Ser Lys Leu Ala Asn 
    210                 215                 220                 


Ile Leu Phe Thr Arg Glu Leu Ala Arg Arg Leu Glu Gly Thr Asn Val 
225                 230                 235                 240 


Thr Val Asn Val Leu His Pro Gly Ile Val Arg Thr Asn Leu Gly Arg 
                245                 250                 255     


His Ile His Ile Pro Leu Leu Val Lys Pro Leu Phe Asn Leu Val Ser 
            260                 265                 270         


Trp Ala Phe Phe Lys Thr Pro Val Glu Gly Ala Gln Thr Ser Ile Tyr 
        275                 280                 285             


Leu Ala Ser Ser Pro Glu Val Glu Gly Val Ser Gly Arg Tyr Phe Gly 
    290                 295                 300                 


Asp Cys Lys Glu Glu Glu Leu Leu Pro Lys Ala Met Asp Glu Ser Val 
305                 310                 315                 320 


Ala Arg Lys Leu Trp Asp Ile Ser Glu Val Met Val Gly Leu Leu Lys 
                325                 330                 335     

<210>  1412
<211>  1243
<212>  DNA
<213>  Homo sapiens

<400>  1412
acggagggcg caggacccag ggcgctgaac tctcacaacc aatcaggcga cccccccaga     60

gggaaactac aagtcccagc atgccccacg cgcaccgtca ggggccgacc cgccgcgccc    120

cagcgttctc cgcgtacagg tggtctcttg ggttccggaa gagcctaggc tggatgtctt    180

gatcaataac gcagggatct tccagtgccc ttacatgaag actgaagatg ggtttgagat    240

gcagttcgga gtgaaccatc tggggcactt tctactcacc aatcttctcc ttggactcct    300

caaaagttca gctcccagca ggattgtggt agtttcttcc aaactttata aatacggaga    360

catcaatttt gatgacttga acagtgaaca aagctataat aaaagctttt gttatagccg    420

gagcaaactg gctaacattc tttttaccag ggaactagcc cgccgcttag aaggcacaaa    480

tgtcaccgtc aatgtgttgc atcctggtat tgtacggaca aatctgggga ggcacataca    540

cattccactg ttggtcaaac cactcttcaa tttggtgtca tgggcttttt tcaaaactcc    600

agtagaaggt gcccagactt ccatttattt ggcctcttca cctgaggtag aaggagtgtc    660

aggaagatac tttggggatt gtaaagagga agaactgttg cccaaagcta tggatgaatc    720

tgttgcaaga aaactctggg atatcagtga agtgatggtt ggcctgctaa aataggaaca    780

aggagtaaaa gagctgttta taaaactgca tatcagttat atctgtgatc aggaatggtg    840

tggattgaga acttgttact tgaagaaaaa gaattttgat attggaatag cctgctaaga    900

ggtacatgtg ggtattttgg agttactgaa aaattatttt tgggataaga gaatttcagc    960

aaagatgttt taaatatata tagtaagtat aatgaataat aagtacaatg aaaaatacaa   1020

ttatattgta aaattataac tgggcaagca tggatgacat attaatattt gtcagaatta   1080

agtgactcaa agtgctatcg agaggttttt caagtatctt tgagtttcat ggccaaagtg   1140

ttaactagtt ttactacaat gtttggtgtt tgtgtggaaa ttatctgcct ggtgtgtgca   1200

cacaagtctt acttggaata aatttactgg tacaaattct taa                     1243


<210>  1413
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  1413


Met Pro His Ala His Arg Gln Gly Pro Thr Arg Arg Ala Pro Ala Phe 
1               5                   10                  15      


Ser Ala Tyr Arg Trp Ser Leu Gly Phe Arg Lys Ser Leu Gly Trp Met 
            20                  25                  30          


Ser 
    

<210>  1414
<211>  3495
<212>  DNA
<213>  Homo sapiens

<400>  1414
attctacact gagtctagcc atggggaagg ggctttgaca gtgtcttcct caacaggttt     60

tgccattgaa agaaacatga gacattaaag ctaaactcaa actcaagtct aaactccatg    120

tctggaacaa aatcccagct gtcaaaaata gtctctagat ctgagaaaag ccctccaaag    180

tctgtctggc agaatgaaca tggataaatg attggatcca caaatgactt tgccattcat    240

tttggcagta ccaggaaaca gacagtcaca aatgggatta atataatgaa tggcagagaa    300

atgcttaaaa agatttaaaa aggaagtggt aatattgata ttgctacata ttgaacattt    360

gaacaatgtt tagacatcaa tttctgaaaa caaagacaat ggctatgagc agatacactc    420

aaaatgaaga aacatttatt ttttgttttt taagaaaagg ttaatcacat attcatagag    480

tcagtttgtt actatggaat cacatatgat gtcataaatt tgacattcta aatgcaaagc    540

tagactgagc aagggaagtg acaggaaatg gagctgggga gacaaaaatg tggataacaa    600

caaaagaatt tcaacaggta aaaaaatgag tcaaacatct ctcaaacaga aaaagaatga    660

gcctggaatg aggtcctcaa aagagagtct agaagcagaa aaaagaaagg aatctgacaa    720

aacaggagtt cgtctgagca atcagatgag gcgtgcagtc aatccgaatc actcgctgag    780

atgttgcccc ttccagggtc actcgtcgtg tagacgctgc ctttgtgcag ctgagggaac    840

agcccttggc ccctgccaca caatacgtat ttatattcac atgtgcctgt tgtgggagca    900

gggccagcag atcaccatga tgaggggatc acaagaatca tcactgcgga agacagactc    960

tcgagggtac cttgtgcgca gtcaatggtc tagaatatcc cggagcccat ccaccaaggc   1020

tccatccata gatgagccta gaagcaggaa caccagtgct aagctcccca gcagctccac   1080

gagctcccgg actccatcca cctccccaag cctgcatgac tcctcaccgc cgccgctgtc   1140

cgggcagccc tcgctccagc cacccgcgtc gccccagctg ccccggtcgc tggactcgcg   1200

gcctcccacg cccccagagc ccgatcctgg ctcccggcgc agcaccaaaa tgcaagagaa   1260

tccggaggcc tgggcccaag gcatcgtgcg ggaaatccgc cagacccggg actcgcagcc   1320

gctggaatat tcgcgcacgt cccccaccga gtggaagtcc tccagccagc gcagggggat   1380

ctaccccgcc tccacccagc tggaccgcaa ctctctgtcc gagcagcagc agcagcagcg   1440

ggaggacgag gacgactacg aggctgccta ctgggcatcc atgaggtcgt tctacgagaa   1500

gaacccgagc tgctcgcgcc cctggccgcc caaacccaag aacgccatca ccattgctct   1560

ctcatcctgc gcgctcttca acatggtgga cggcaggaaa atctacgagc aagagggtct   1620

ggaaaagtac atggagtatc agctcaccaa tgagaacgtc atcctgaccc cgggcccggc   1680

gttccgcttc gtcaaggcac tacagtatgt caatgctaga ctccgtgatc tatatcctga   1740

tgaacaggac ttatttgata ttgtactgat gactaataac catgcccaag tgggagtgcg   1800

gcttataaac agcgtcaatc actacggctt actgattgac cgcttctgtc tgaccggggg   1860

aaaagacccc attggctatt tgaaggcata tcttaccaac ttgtatattg ctgcagattc   1920

tgaaaaagtg caagaggcaa tacaagaagg tattgcctct gcgacaatgt ttgatggagc   1980

caaagacatg gcttactgtg acactcagct ccgtgtagcc tttgatgggg atgctgtcct   2040

cttctctgat gagtctgaac attttaccaa ggagcatggg ctcgacaaat tcttccagta   2100

tgatacatta tgtgaaagta agcctcttgc tcagggtccc ctaaaaggct ttctggaaga   2160

tttaggcaga ctgcaaaaga agttctatgc caaaaatgaa cggttacttt gtcctatcag   2220

gacctacctg gttacagcta ggagtgcagc cagttcaggc gcccgtgtgc tgaagaccct   2280

tcgacgctgg ggtctagaga tagacgaagc tcttttcctt gctggagccc ccaaaagtcc   2340

catcttggtg aagatccggc cccacatctt ctttgatgac cacatgttcc acattgaagg   2400

ggcacagagg aagagcctag gctggatgtc ttgatcaata acgcagggat cttccagtgc   2460

ccttacatga agactgaaga tgggtttgag atgcagttcg gagtgaacca tctggggcac   2520

tttctactca ccaatcttct ccttggactc ctcaaaagtt cagctcccag caggattgtg   2580

gtagtttctt ccaaacttta taaatacgga gacatcaatt ttgatgactt gaacagtgaa   2640

caaagctata ataaaagctt ttgttatagc cggagcaaac tggctaacat tctttttacc   2700

agggaactag cccgccgctt agaaggcaca aatgtcaccg tcaatgtgtt gcatcctggt   2760

attgtacgga caaatctggg gaggcacata cacattccac tgttggtcaa accactcttc   2820

aatttggtgt catgggcttt tttcaaaact ccagtagaag gtgcccagac ttccatttat   2880

ttggcctctt cacctgaggt agaaggagtg tcaggaagat actttgggga ttgtaaagag   2940

gaagaactgt tgcccaaagc tatggatgaa tctgttgcaa gaaaactctg ggatatcagt   3000

gaagtgatgg ttggcctgct aaaataggaa caaggagtaa aagagctgtt tataaaactg   3060

catatcagtt atatctgtga tcaggaatgg tgtggattga gaacttgtta cttgaagaaa   3120

aagaattttg atattggaat agcctgctaa gaggtacatg tgggtatttt ggagttactg   3180

aaaaattatt tttgggataa gagaatttca gcaaagatgt tttaaatata tatagtaagt   3240

ataatgaata ataagtacaa tgaaaaatac aattatattg taaaattata actgggcaag   3300

catggatgac atattaatat ttgtcagaat taagtgactc aaagtgctat cgagaggttt   3360

ttcaagtatc tttgagtttc atggccaaag tgttaactag ttttactaca atgtttggtg   3420

tttgtgtgga aattatctgc ctggtgtgtg cacacaagtc ttacttggaa taaatttact   3480

ggtacaaatt cttaa                                                    3495


<210>  1415
<211>  602
<212>  PRT
<213>  Homo sapiens

<400>  1415


Met Ser Gln Thr Ser Leu Lys Gln Lys Lys Asn Glu Pro Gly Met Arg 
1               5                   10                  15      


Ser Ser Lys Glu Ser Leu Glu Ala Glu Lys Arg Lys Glu Ser Asp Lys 
            20                  25                  30          


Thr Gly Val Arg Leu Ser Asn Gln Met Arg Arg Ala Val Asn Pro Asn 
        35                  40                  45              


His Ser Leu Arg Cys Cys Pro Phe Gln Gly His Ser Ser Cys Arg Arg 
    50                  55                  60                  


Cys Leu Cys Ala Ala Glu Gly Thr Ala Leu Gly Pro Cys His Thr Ile 
65                  70                  75                  80  


Arg Ile Tyr Ile His Met Cys Leu Leu Trp Glu Gln Gly Gln Gln Ile 
                85                  90                  95      


Thr Met Met Arg Gly Ser Gln Glu Ser Ser Leu Arg Lys Thr Asp Ser 
            100                 105                 110         


Arg Gly Tyr Leu Val Arg Ser Gln Trp Ser Arg Ile Ser Arg Ser Pro 
        115                 120                 125             


Ser Thr Lys Ala Pro Ser Ile Asp Glu Pro Arg Ser Arg Asn Thr Ser 
    130                 135                 140                 


Ala Lys Leu Pro Ser Ser Ser Thr Ser Ser Arg Thr Pro Ser Thr Ser 
145                 150                 155                 160 


Pro Ser Leu His Asp Ser Ser Pro Pro Pro Leu Ser Gly Gln Pro Ser 
                165                 170                 175     


Leu Gln Pro Pro Ala Ser Pro Gln Leu Pro Arg Ser Leu Asp Ser Arg 
            180                 185                 190         


Pro Pro Thr Pro Pro Glu Pro Asp Pro Gly Ser Arg Arg Ser Thr Lys 
        195                 200                 205             


Met Gln Glu Asn Pro Glu Ala Trp Ala Gln Gly Ile Val Arg Glu Ile 
    210                 215                 220                 


Arg Gln Thr Arg Asp Ser Gln Pro Leu Glu Tyr Ser Arg Thr Ser Pro 
225                 230                 235                 240 


Thr Glu Trp Lys Ser Ser Ser Gln Arg Arg Gly Ile Tyr Pro Ala Ser 
                245                 250                 255     


Thr Gln Leu Asp Arg Asn Ser Leu Ser Glu Gln Gln Gln Gln Gln Arg 
            260                 265                 270         


Glu Asp Glu Asp Asp Tyr Glu Ala Ala Tyr Trp Ala Ser Met Arg Ser 
        275                 280                 285             


Phe Tyr Glu Lys Asn Pro Ser Cys Ser Arg Pro Trp Pro Pro Lys Pro 
    290                 295                 300                 


Lys Asn Ala Ile Thr Ile Ala Leu Ser Ser Cys Ala Leu Phe Asn Met 
305                 310                 315                 320 


Val Asp Gly Arg Lys Ile Tyr Glu Gln Glu Gly Leu Glu Lys Tyr Met 
                325                 330                 335     


Glu Tyr Gln Leu Thr Asn Glu Asn Val Ile Leu Thr Pro Gly Pro Ala 
            340                 345                 350         


Phe Arg Phe Val Lys Ala Leu Gln Tyr Val Asn Ala Arg Leu Arg Asp 
        355                 360                 365             


Leu Tyr Pro Asp Glu Gln Asp Leu Phe Asp Ile Val Leu Met Thr Asn 
    370                 375                 380                 


Asn His Ala Gln Val Gly Val Arg Leu Ile Asn Ser Val Asn His Tyr 
385                 390                 395                 400 


Gly Leu Leu Ile Asp Arg Phe Cys Leu Thr Gly Gly Lys Asp Pro Ile 
                405                 410                 415     


Gly Tyr Leu Lys Ala Tyr Leu Thr Asn Leu Tyr Ile Ala Ala Asp Ser 
            420                 425                 430         


Glu Lys Val Gln Glu Ala Ile Gln Glu Gly Ile Ala Ser Ala Thr Met 
        435                 440                 445             


Phe Asp Gly Ala Lys Asp Met Ala Tyr Cys Asp Thr Gln Leu Arg Val 
    450                 455                 460                 


Ala Phe Asp Gly Asp Ala Val Leu Phe Ser Asp Glu Ser Glu His Phe 
465                 470                 475                 480 


Thr Lys Glu His Gly Leu Asp Lys Phe Phe Gln Tyr Asp Thr Leu Cys 
                485                 490                 495     


Glu Ser Lys Pro Leu Ala Gln Gly Pro Leu Lys Gly Phe Leu Glu Asp 
            500                 505                 510         


Leu Gly Arg Leu Gln Lys Lys Phe Tyr Ala Lys Asn Glu Arg Leu Leu 
        515                 520                 525             


Cys Pro Ile Arg Thr Tyr Leu Val Thr Ala Arg Ser Ala Ala Ser Ser 
    530                 535                 540                 


Gly Ala Arg Val Leu Lys Thr Leu Arg Arg Trp Gly Leu Glu Ile Asp 
545                 550                 555                 560 


Glu Ala Leu Phe Leu Ala Gly Ala Pro Lys Ser Pro Ile Leu Val Lys 
                565                 570                 575     


Ile Arg Pro His Ile Phe Phe Asp Asp His Met Phe His Ile Glu Gly 
            580                 585                 590         


Ala Gln Arg Lys Ser Leu Gly Trp Met Ser 
        595                 600         

<210>  1416
<211>  1312
<212>  DNA
<213>  Homo sapiens

<400>  1416
acggagggcg caggacccag ggcgctgaac tctcacaacc aatcaggcga cccccccaga     60

gggaaactac aagtcccagc atgccccacg cgcaccgtca ggggccgacc cgccgcgccc    120

cagcgttctc cgcgtacagg tggtctcttg ggttccggta aggcggcggc tgcggaactc    180

ccgtggaggg gccggtgggc cctcgggcct gacgatggca gtggccactg cggcggcagt    240

actggccgct ctgggcgggg cgctgtggct ggcggcccgc cggttcgtgg ggcccagggt    300

ccagcggctg cgcagaggcg gggaccccgg cctcatgcac gggaagactg tgctgatcac    360

cggggcgaac agcggcctgg gccgcgccac ggccgccgag ctactgcgcc tgggagcgcg    420

ggtgatcatg ggctgccggg accgcgcgcg cgccgaggag gcggcgggtc agctccgccg    480

cgagctccgc caggccgcgg agtgcggccc agagcctggc gtcagcgggg tgggcgagct    540

catagtccgg gagctggacc tcgcctcgct gcgctcggtg cgcgccttct gccaggaaat    600

gctccaggaa gagcctaggc tggatgtctt gatcaataac gcagggatct tccagtgccc    660

ttacatgaag actgaagatg ggtttgagat gcagttcgga gtgaaccatc tggggcactt    720

tctactcacc aatcttctcc ttggactcct caaaagttca gctcccagca ggattgtggt    780

agtttcttcc aaactttata aatacggaga catcaatttt gatgacttga acagtgaaca    840

aagctataat aaaagctttt gttatagccg gagcaaactg gctaacattc tttttaccag    900

ggaactagcc cgccgcttag aaggcacaaa tgtcaccgtc aatgtgttgc atcctggtat    960

tgtacggaca aatctgggga ggcacataca cattccactg ttggtcaaac cactcttcaa   1020

tttggtgtca tgggcttttt tcaaaactcc agtagaaggt gcccagactt ccatttattt   1080

ggcctcttca cctgaggtag aaggagtgtc aggaagatac tttggggatt gtaaagagga   1140

agaactgttg cccaaagcta tggatgaatc tgttgcaaga aaactctggg atatcagtga   1200

agtgatggtt ggcctgctaa aataggaaca aggagtaaaa gagctgttta taaaactgca   1260

tatcagttat atctgtgatc aggaatggtg tggattgaga acttgttact tg           1312


<210>  1417
<211>  336
<212>  PRT
<213>  Homo sapiens

<400>  1417


Met Ala Val Ala Thr Ala Ala Ala Val Leu Ala Ala Leu Gly Gly Ala 
1               5                   10                  15      


Leu Trp Leu Ala Ala Arg Arg Phe Val Gly Pro Arg Val Gln Arg Leu 
            20                  25                  30          


Arg Arg Gly Gly Asp Pro Gly Leu Met His Gly Lys Thr Val Leu Ile 
        35                  40                  45              


Thr Gly Ala Asn Ser Gly Leu Gly Arg Ala Thr Ala Ala Glu Leu Leu 
    50                  55                  60                  


Arg Leu Gly Ala Arg Val Ile Met Gly Cys Arg Asp Arg Ala Arg Ala 
65                  70                  75                  80  


Glu Glu Ala Ala Gly Gln Leu Arg Arg Glu Leu Arg Gln Ala Ala Glu 
                85                  90                  95      


Cys Gly Pro Glu Pro Gly Val Ser Gly Val Gly Glu Leu Ile Val Arg 
            100                 105                 110         


Glu Leu Asp Leu Ala Ser Leu Arg Ser Val Arg Ala Phe Cys Gln Glu 
        115                 120                 125             


Met Leu Gln Glu Glu Pro Arg Leu Asp Val Leu Ile Asn Asn Ala Gly 
    130                 135                 140                 


Ile Phe Gln Cys Pro Tyr Met Lys Thr Glu Asp Gly Phe Glu Met Gln 
145                 150                 155                 160 


Phe Gly Val Asn His Leu Gly His Phe Leu Leu Thr Asn Leu Leu Leu 
                165                 170                 175     


Gly Leu Leu Lys Ser Ser Ala Pro Ser Arg Ile Val Val Val Ser Ser 
            180                 185                 190         


Lys Leu Tyr Lys Tyr Gly Asp Ile Asn Phe Asp Asp Leu Asn Ser Glu 
        195                 200                 205             


Gln Ser Tyr Asn Lys Ser Phe Cys Tyr Ser Arg Ser Lys Leu Ala Asn 
    210                 215                 220                 


Ile Leu Phe Thr Arg Glu Leu Ala Arg Arg Leu Glu Gly Thr Asn Val 
225                 230                 235                 240 


Thr Val Asn Val Leu His Pro Gly Ile Val Arg Thr Asn Leu Gly Arg 
                245                 250                 255     


His Ile His Ile Pro Leu Leu Val Lys Pro Leu Phe Asn Leu Val Ser 
            260                 265                 270         


Trp Ala Phe Phe Lys Thr Pro Val Glu Gly Ala Gln Thr Ser Ile Tyr 
        275                 280                 285             


Leu Ala Ser Ser Pro Glu Val Glu Gly Val Ser Gly Arg Tyr Phe Gly 
    290                 295                 300                 


Asp Cys Lys Glu Glu Glu Leu Leu Pro Lys Ala Met Asp Glu Ser Val 
305                 310                 315                 320 


Ala Arg Lys Leu Trp Asp Ile Ser Glu Val Met Val Gly Leu Leu Lys 
                325                 330                 335     

<210>  1418
<211>  1721
<212>  DNA
<213>  Homo sapiens

<400>  1418
gaggaaggga ctccagccca cagccctaga tttggcacta cagtatgtca atgctagact     60

ccgtgatcta tatcctgatg aacaggactt atttgatatt gtactgatga ctaataacca    120

tgcccaagtg ggagtgcggc ttataaacag cgtcaatcac tacggcttac tgattgaccg    180

cttctgtctg accgggggaa aagaccccat tggctatttg aaggcatatc ttaccaactt    240

gtatattgct gcagattctg aaaaagtgca agaggcaata caagaaggta ttgcctctgc    300

gacaatgttt gatggagcca aagacatggc ttactgtgac actcagctcc gtgtagcctt    360

tgatggggat gctgtcctct tctctgatga gtctgaacat tttaccaagg agcatgggct    420

cgacaaattc ttccagtatg atacattatg tgaaagtaag cctcttgctc agggtcccct    480

aaaaggcttt ctggaagatt taggcagact gcaaaagaag ttctatgcca aaaatgaacg    540

gttactttgt cctatcagga cctacctggt tacagctagg agtgcagcca gttcaggcgc    600

ccgtgtgctg aagacccttc gacgctgggg tctagagata gacgaagctc ttttccttgc    660

tggagccccc aaaagtccca tcttggtgaa gatccggccc cacatcttct ttgatgacca    720

catgttccac attgaagggg cacagaggtt aggttccatc gcagcttatg gctttaataa    780

aaaattcagt agttaggggc agggaggaga aataaagtgg tgatagtctg gtgttacaga    840

agccacttct tttggctctc taggataatt agataggtat ttcagaaaat tggaccttaa    900

aactttgctt ctttggaaag gttttctcct gattttttgg aaaacctttt gaaccctcaa    960

gttaccatca aactacttct ctttgaacta ccaatactgt tgaatgccat tacacctatc   1020

tctgtgtaag tcataatgat gactctttag gataagttta gaacttgaat atttgcatgc   1080

ttaaggcact gttttagaag cttacttagt tttataaaca ctgctcattt ttggatgttt   1140

gtagataaca atgaattgtt acccatcagc attgtagaat agtgtcttca aaggtagaag   1200

gagtatggtt aagcacactc ttgaaaactg gagctttgta ttctgtgact gctatggcta   1260

gctttgtaac caaagcaaaa tgagaatttc actctacctg catgagtata acaattttga   1320

tactgctcat ttagaaataa atcatctggt tgttcctcca gggtactttc taagataagc   1380

cttaaacaga aacccctaag aaaggttctc tgaaaattat ttggtgggtt aaatgcctct   1440

gatccacaga gtttcatatt tgaagtctcc ggctttgggc ctggcaggct ggcacatcca   1500

tatttgtatg gaaaaaaaaa aaaaagaccc tacgctacca cttcaaaaag tgacatgaag   1560

tgtagtatcc tggcccttca ttgtcattct ctcatgattt ttgttttgtt ttcaacaaaa   1620

attggttggt cattaaatat atcatatgtt aggcacagtg acctggttat tttcacatgt   1680

tacttcattt tcttatcaaa ttaaatgttt gtgacatagt a                       1721


<210>  1419
<211>  229
<212>  PRT
<213>  Homo sapiens

<400>  1419


Met Thr Asn Asn His Ala Gln Val Gly Val Arg Leu Ile Asn Ser Val 
1               5                   10                  15      


Asn His Tyr Gly Leu Leu Ile Asp Arg Phe Cys Leu Thr Gly Gly Lys 
            20                  25                  30          


Asp Pro Ile Gly Tyr Leu Lys Ala Tyr Leu Thr Asn Leu Tyr Ile Ala 
        35                  40                  45              


Ala Asp Ser Glu Lys Val Gln Glu Ala Ile Gln Glu Gly Ile Ala Ser 
    50                  55                  60                  


Ala Thr Met Phe Asp Gly Ala Lys Asp Met Ala Tyr Cys Asp Thr Gln 
65                  70                  75                  80  


Leu Arg Val Ala Phe Asp Gly Asp Ala Val Leu Phe Ser Asp Glu Ser 
                85                  90                  95      


Glu His Phe Thr Lys Glu His Gly Leu Asp Lys Phe Phe Gln Tyr Asp 
            100                 105                 110         


Thr Leu Cys Glu Ser Lys Pro Leu Ala Gln Gly Pro Leu Lys Gly Phe 
        115                 120                 125             


Leu Glu Asp Leu Gly Arg Leu Gln Lys Lys Phe Tyr Ala Lys Asn Glu 
    130                 135                 140                 


Arg Leu Leu Cys Pro Ile Arg Thr Tyr Leu Val Thr Ala Arg Ser Ala 
145                 150                 155                 160 


Ala Ser Ser Gly Ala Arg Val Leu Lys Thr Leu Arg Arg Trp Gly Leu 
                165                 170                 175     


Glu Ile Asp Glu Ala Leu Phe Leu Ala Gly Ala Pro Lys Ser Pro Ile 
            180                 185                 190         


Leu Val Lys Ile Arg Pro His Ile Phe Phe Asp Asp His Met Phe His 
        195                 200                 205             


Ile Glu Gly Ala Gln Arg Leu Gly Ser Ile Ala Ala Tyr Gly Phe Asn 
    210                 215                 220                 


Lys Lys Phe Ser Ser 
225                 

<210>  1420
<211>  3137
<212>  DNA
<213>  Homo sapiens

<400>  1420
attctacact gagtctagcc atggggaagg ggctttgaca gtgtcttcct caacaggttt     60

tgccattgaa agaaacatga gacattaaag ctaaactcaa actcaagtct aaactccatg    120

tctggaacaa aatcccagct gtcaaaaata gtctctagat ctgagaaaag ccctccaaag    180

tctgtctggc agaatgaaca tggataaatg attggatcca caaatgactt tgccattcat    240

tttggcagta ccaggaaaca gacagtcaca aatgggatta atataatgaa tggcagagaa    300

atgcttaaaa agatttaaaa aggaagtggt aatattgata ttgctacata ttgaacattt    360

gaacaatgtt tagacatcaa tttctgaaaa caaagacaat ggctatgagc agatacactc    420

aaaatgaaga aacatttatt ttttgttttt taagaaaagg ttaatcacat attcatagag    480

tcagtttgtt actatggaat cacatatgat gtcataaatt tgacattcta aatgcaaagc    540

tagactgagc aagggaagtg acaggaaatg gagctgggga gacaaaaatg tggataacaa    600

caaaagaatt tcaacaggta aaaaaatgag tcaaacatct ctcaaacaga aaaagaatga    660

gcctggaatg aggtcctcaa aagagagtct agaagcagaa aaaagaaagg aatctgacaa    720

aacaggagtt cgtctgagca atcagggatc acaagaatca tcactgcgga agacagactc    780

tcgagggtac cttgtgcgca gtcaatggtc tagaatatcc cggagcccat ccaccaaggc    840

tccatccata gatgagccta gaagcaggaa caccagtgct aaggtagagc tgtccgggca    900

gccctcgctc cagccacccg cgtcgcccca gctgccccgg tcgctggact cgcggcctcc    960

cacgccccca gagcccgatc ctggctcccg gcgcagcacc aaaatgcaag agaatccgga   1020

ggcctgggcc caaggcatcg tgcgggaaat ccgccagacc cgggactcgc agccgctgga   1080

atattcgcgc acgtccccca ccgagtggaa gtcctccagc cagcgcaggg ggatctaccc   1140

cgcctccacc cagctggacc gcaactctct gtccgagcag cagcagcagc agcgggagga   1200

cgaggacgac tacgaggctg cctactgggc atccatgagg tcgttctacg agaagaaccc   1260

gagctgctcg cgcccctggc cgcccaaacc caagaacgcc atcaccattg ctctctcatc   1320

ctgcgcgctc ttcaacatgg tggacggcag gaaaatctac gagcaagagg gtctggaaaa   1380

gtacatggag tatcagctca ccaatgagaa cgtcatcctg accccgggcc cggcgttccg   1440

cttcgtcaag gcactacagt atgtcaatgc tagactccgt gatctatatc ctgatgaaca   1500

ggacttattt gatattgtac tgatgactaa taaccatgcc caagtgggag tgcggcttat   1560

aaacagcgtc aatcactacg gcttactgat tgaccgcttc tgtctgaccg ggggaaaaga   1620

ccccattggc tatttgaagg catatcttac caacttgtat attgctgcag attctgaaaa   1680

agtgcaagag gcaatacaag aaggtattgc ctctgcgaca atgtttgatg gagccaaaga   1740

catggcttac tgtgacactc agctccgtgt agcctttgat ggggatgctg tcctcttctc   1800

tgatgagtct gaacatttta ccaaggagca tgggctcgac aaattcttcc agtatgatac   1860

attatgtgaa agtaagcctc ttgctcaggg tcccctaaaa ggctttctgg aagatttagg   1920

cagactgcaa aagaagttct atgccaaaaa tgaacggtta ctttgtccta tcaggaccta   1980

cctggttaca gctaggagtg cagccagttc aggcgcccgt gtgctgaaga cccttcgacg   2040

ctggggtcta gagatagacg aagctctttt ccttgctgga gcccccaaaa gtcccatctt   2100

ggtgaagatc cggccccaca tcttctttga tgaccacatg ttccacattg aaggggcaca   2160

gaggttaggt tccatcgcag cttatggctt taataaaaaa ttcagtagtt aggggcaggg   2220

aggagaaata aagtggtgat agtctggtgt tacagaagcc acttcttttg gctctctagg   2280

ataattagat aggtatttca gaaaattgga ccttaaaact ttgcttcttt ggaaaggttt   2340

tctcctgatt ttttggaaaa ccttttgaac cctcaagtta ccatcaaact acttctcttt   2400

gaactaccaa tactgttgaa tgccattaca cctatctctg tgtaagtcat aatgatgact   2460

ctttaggata agtttagaac ttgaatattt gcatgcttaa ggcactgttt tagaagctta   2520

cttagtttta taaacactgc tcatttttgg atgtttgtag ataacaatga attgttaccc   2580

atcagcattg tagaatagtg tcttcaaagg tagaaggagt atggttaagc acactcttga   2640

aaactggagc tttgtattct gtgactgcta tggctagctt tgtaaccaaa gcaaaatgag   2700

aatttcactc tacctgcatg agtataacaa ttttgatact gctcatttag aaataaatca   2760

tctggttgtt cctccagggt actttctaag ataagcctta aacagaaacc cctaagaaag   2820

gttctctgaa aattatttgg tgggttaaat gcctctgatc cacagagttt catatttgaa   2880

gtctccggct ttgggcctgg caggctggca catccatatt tgtatggaaa aaaaaaaaaa   2940

agaccctacg ctaccacttc aaaaagtgac atgaagtgta gtatcctggc ccttcattgt   3000

cattctctca tgatttttgt tttgttttca acaaaaattg gttggtcatt aaatatatca   3060

tatgttaggc acagtgacct ggttattttc acatgttact tcattttctt atcaaattaa   3120

atgtttgtga catagta                                                  3137


<210>  1421
<211>  528
<212>  PRT
<213>  Homo sapiens

<400>  1421


Met Ser Gln Thr Ser Leu Lys Gln Lys Lys Asn Glu Pro Gly Met Arg 
1               5                   10                  15      


Ser Ser Lys Glu Ser Leu Glu Ala Glu Lys Arg Lys Glu Ser Asp Lys 
            20                  25                  30          


Thr Gly Val Arg Leu Ser Asn Gln Gly Ser Gln Glu Ser Ser Leu Arg 
        35                  40                  45              


Lys Thr Asp Ser Arg Gly Tyr Leu Val Arg Ser Gln Trp Ser Arg Ile 
    50                  55                  60                  


Ser Arg Ser Pro Ser Thr Lys Ala Pro Ser Ile Asp Glu Pro Arg Ser 
65                  70                  75                  80  


Arg Asn Thr Ser Ala Lys Val Glu Leu Ser Gly Gln Pro Ser Leu Gln 
                85                  90                  95      


Pro Pro Ala Ser Pro Gln Leu Pro Arg Ser Leu Asp Ser Arg Pro Pro 
            100                 105                 110         


Thr Pro Pro Glu Pro Asp Pro Gly Ser Arg Arg Ser Thr Lys Met Gln 
        115                 120                 125             


Glu Asn Pro Glu Ala Trp Ala Gln Gly Ile Val Arg Glu Ile Arg Gln 
    130                 135                 140                 


Thr Arg Asp Ser Gln Pro Leu Glu Tyr Ser Arg Thr Ser Pro Thr Glu 
145                 150                 155                 160 


Trp Lys Ser Ser Ser Gln Arg Arg Gly Ile Tyr Pro Ala Ser Thr Gln 
                165                 170                 175     


Leu Asp Arg Asn Ser Leu Ser Glu Gln Gln Gln Gln Gln Arg Glu Asp 
            180                 185                 190         


Glu Asp Asp Tyr Glu Ala Ala Tyr Trp Ala Ser Met Arg Ser Phe Tyr 
        195                 200                 205             


Glu Lys Asn Pro Ser Cys Ser Arg Pro Trp Pro Pro Lys Pro Lys Asn 
    210                 215                 220                 


Ala Ile Thr Ile Ala Leu Ser Ser Cys Ala Leu Phe Asn Met Val Asp 
225                 230                 235                 240 


Gly Arg Lys Ile Tyr Glu Gln Glu Gly Leu Glu Lys Tyr Met Glu Tyr 
                245                 250                 255     


Gln Leu Thr Asn Glu Asn Val Ile Leu Thr Pro Gly Pro Ala Phe Arg 
            260                 265                 270         


Phe Val Lys Ala Leu Gln Tyr Val Asn Ala Arg Leu Arg Asp Leu Tyr 
        275                 280                 285             


Pro Asp Glu Gln Asp Leu Phe Asp Ile Val Leu Met Thr Asn Asn His 
    290                 295                 300                 


Ala Gln Val Gly Val Arg Leu Ile Asn Ser Val Asn His Tyr Gly Leu 
305                 310                 315                 320 


Leu Ile Asp Arg Phe Cys Leu Thr Gly Gly Lys Asp Pro Ile Gly Tyr 
                325                 330                 335     


Leu Lys Ala Tyr Leu Thr Asn Leu Tyr Ile Ala Ala Asp Ser Glu Lys 
            340                 345                 350         


Val Gln Glu Ala Ile Gln Glu Gly Ile Ala Ser Ala Thr Met Phe Asp 
        355                 360                 365             


Gly Ala Lys Asp Met Ala Tyr Cys Asp Thr Gln Leu Arg Val Ala Phe 
    370                 375                 380                 


Asp Gly Asp Ala Val Leu Phe Ser Asp Glu Ser Glu His Phe Thr Lys 
385                 390                 395                 400 


Glu His Gly Leu Asp Lys Phe Phe Gln Tyr Asp Thr Leu Cys Glu Ser 
                405                 410                 415     


Lys Pro Leu Ala Gln Gly Pro Leu Lys Gly Phe Leu Glu Asp Leu Gly 
            420                 425                 430         


Arg Leu Gln Lys Lys Phe Tyr Ala Lys Asn Glu Arg Leu Leu Cys Pro 
        435                 440                 445             


Ile Arg Thr Tyr Leu Val Thr Ala Arg Ser Ala Ala Ser Ser Gly Ala 
    450                 455                 460                 


Arg Val Leu Lys Thr Leu Arg Arg Trp Gly Leu Glu Ile Asp Glu Ala 
465                 470                 475                 480 


Leu Phe Leu Ala Gly Ala Pro Lys Ser Pro Ile Leu Val Lys Ile Arg 
                485                 490                 495     


Pro His Ile Phe Phe Asp Asp His Met Phe His Ile Glu Gly Ala Gln 
            500                 505                 510         


Arg Leu Gly Ser Ile Ala Ala Tyr Gly Phe Asn Lys Lys Phe Ser Ser 
        515                 520                 525             

<210>  1422
<211>  3203
<212>  DNA
<213>  Homo sapiens

<400>  1422
attctacact gagtctagcc atggggaagg ggctttgaca gtgtcttcct caacaggttt     60

tgccattgaa agaaacatga gacattaaag ctaaactcaa actcaagtct aaactccatg    120

tctggaacaa aatcccagct gtcaaaaata gtctctagat ctgagaaaag ccctccaaag    180

tctgtctggc agaatgaaca tggataaatg attggatcca caaatgactt tgccattcat    240

tttggcagta ccaggaaaca gacagtcaca aatgggatta atataatgaa tggcagagaa    300

atgcttaaaa agatttaaaa aggaagtggt aatattgata ttgctacata ttgaacattt    360

gaacaatgtt tagacatcaa tttctgaaaa caaagacaat ggctatgagc agatacactc    420

aaaatgaaga aacatttatt ttttgttttt taagaaaagg ttaatcacat attcatagag    480

tcagtttgtt actatggaat cacatatgat gtcataaatt tgacattcta aatgcaaagc    540

tagactgagc aagggaagtg acaggaaatg gagctgggga gacaaaaatg tggataacaa    600

caaaagaatt tcaacaggta aaaaaatgag tcaaacatct ctcaaacaga aaaagaatga    660

gcctggaatg aggtcctcaa aagagagtct agaagcagaa aaaagaaagg aatctgacaa    720

aacaggagtt cgtctgagca atcagggatc acaagaatca tcactgcgga agacagactc    780

tcgagggtac cttgtgcgca gtcaatggtc tagaatatcc cggagcccat ccaccaaggc    840

tccatccata gatgagccta gaagcaggaa caccagtgct aagctcccca gcagctccac    900

gagctcccgg actccatcca cctccccaag cctgcatgac tcctcaccgc cgccgctgtc    960

cgggcagccc tcgctccagc cacccgcgtc gccccagctg ccccggtcgc tggactcgcg   1020

gcctcccacg cccccagagc ccgatcctgg ctcccggcgc agcaccaaaa tgcaagagaa   1080

tccggaggcc tgggcccaag gcatcgtgcg ggaaatccgc cagacccggg actcgcagcc   1140

gctggaatat tcgcgcacgt cccccaccga gtggaagtcc tccagccagc gcagggggat   1200

ctaccccgcc tccacccagc tggaccgcaa ctctctgtcc gagcagcagc agcagcagcg   1260

ggaggacgag gacgactacg aggctgccta ctgggcatcc atgaggtcgt tctacgagaa   1320

gaacccgagc tgctcgcgcc cctggccgcc caaacccaag aacgccatca ccattgctct   1380

ctcatcctgc gcgctcttca acatggtgga cggcaggaaa atctacgagc aagagggtct   1440

ggaaaagtac atggagtatc agctcaccaa tgagaacgtc atcctgaccc cgggcccggc   1500

gttccgcttc gtcaaggcac tacagtatgt caatgctaga ctccgtgatc tatatcctga   1560

tgaacaggac ttatttgata ttgtactgat gactaataac catgcccaag tgggagtgcg   1620

gcttataaac agcgtcaatc actacggctt actgattgac cgcttctgtc tgaccggggg   1680

aaaagacccc attggctatt tgaaggcata tcttaccaac ttgtatattg ctgcagattc   1740

tgaaaaagtg caagaggcaa tacaagaagg tattgcctct gcgacaatgt ttgatggagc   1800

caaagacatg gcttactgtg acactcagct ccgtgtagcc tttgatgggg atgctgtcct   1860

cttctctgat gagtctgaac attttaccaa ggagcatggg ctcgacaaat tcttccagta   1920

tgatacatta tgtgaaagta agcctcttgc tcagggtccc ctaaaaggct ttctggaaga   1980

tttaggcaga ctgcaaaaga agttctatgc caaaaatgaa cggttacttt gtcctatcag   2040

gacctacctg gttacagcta ggagtgcagc cagttcaggc gcccgtgtgc tgaagaccct   2100

tcgacgctgg ggtctagaga tagacgaagc tcttttcctt gctggagccc ccaaaagtcc   2160

catcttggtg aagatccggc cccacatctt ctttgatgac cacatgttcc acattgaagg   2220

ggcacagagg ttaggttcca tcgcagctta tggctttaat aaaaaattca gtagttaggg   2280

gcagggagga gaaataaagt ggtgatagtc tggtgttaca gaagccactt cttttggctc   2340

tctaggataa ttagataggt atttcagaaa attggacctt aaaactttgc ttctttggaa   2400

aggttttctc ctgatttttt ggaaaacctt ttgaaccctc aagttaccat caaactactt   2460

ctctttgaac taccaatact gttgaatgcc attacaccta tctctgtgta agtcataatg   2520

atgactcttt aggataagtt tagaacttga atatttgcat gcttaaggca ctgttttaga   2580

agcttactta gttttataaa cactgctcat ttttggatgt ttgtagataa caatgaattg   2640

ttacccatca gcattgtaga atagtgtctt caaaggtaga aggagtatgg ttaagcacac   2700

tcttgaaaac tggagctttg tattctgtga ctgctatggc tagctttgta accaaagcaa   2760

aatgagaatt tcactctacc tgcatgagta taacaatttt gatactgctc atttagaaat   2820

aaatcatctg gttgttcctc cagggtactt tctaagataa gccttaaaca gaaaccccta   2880

agaaaggttc tctgaaaatt atttggtggg ttaaatgcct ctgatccaca gagtttcata   2940

tttgaagtct ccggctttgg gcctggcagg ctggcacatc catatttgta tggaaaaaaa   3000

aaaaaaagac cctacgctac cacttcaaaa agtgacatga agtgtagtat cctggccctt   3060

cattgtcatt ctctcatgat ttttgttttg ttttcaacaa aaattggttg gtcattaaat   3120

atatcatatg ttaggcacag tgacctggtt attttcacat gttacttcat tttcttatca   3180

aattaaatgt ttgtgacata gta                                           3203


<210>  1423
<211>  550
<212>  PRT
<213>  Homo sapiens

<400>  1423


Met Ser Gln Thr Ser Leu Lys Gln Lys Lys Asn Glu Pro Gly Met Arg 
1               5                   10                  15      


Ser Ser Lys Glu Ser Leu Glu Ala Glu Lys Arg Lys Glu Ser Asp Lys 
            20                  25                  30          


Thr Gly Val Arg Leu Ser Asn Gln Gly Ser Gln Glu Ser Ser Leu Arg 
        35                  40                  45              


Lys Thr Asp Ser Arg Gly Tyr Leu Val Arg Ser Gln Trp Ser Arg Ile 
    50                  55                  60                  


Ser Arg Ser Pro Ser Thr Lys Ala Pro Ser Ile Asp Glu Pro Arg Ser 
65                  70                  75                  80  


Arg Asn Thr Ser Ala Lys Leu Pro Ser Ser Ser Thr Ser Ser Arg Thr 
                85                  90                  95      


Pro Ser Thr Ser Pro Ser Leu His Asp Ser Ser Pro Pro Pro Leu Ser 
            100                 105                 110         


Gly Gln Pro Ser Leu Gln Pro Pro Ala Ser Pro Gln Leu Pro Arg Ser 
        115                 120                 125             


Leu Asp Ser Arg Pro Pro Thr Pro Pro Glu Pro Asp Pro Gly Ser Arg 
    130                 135                 140                 


Arg Ser Thr Lys Met Gln Glu Asn Pro Glu Ala Trp Ala Gln Gly Ile 
145                 150                 155                 160 


Val Arg Glu Ile Arg Gln Thr Arg Asp Ser Gln Pro Leu Glu Tyr Ser 
                165                 170                 175     


Arg Thr Ser Pro Thr Glu Trp Lys Ser Ser Ser Gln Arg Arg Gly Ile 
            180                 185                 190         


Tyr Pro Ala Ser Thr Gln Leu Asp Arg Asn Ser Leu Ser Glu Gln Gln 
        195                 200                 205             


Gln Gln Gln Arg Glu Asp Glu Asp Asp Tyr Glu Ala Ala Tyr Trp Ala 
    210                 215                 220                 


Ser Met Arg Ser Phe Tyr Glu Lys Asn Pro Ser Cys Ser Arg Pro Trp 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asn Ala Ile Thr Ile Ala Leu Ser Ser Cys Ala 
                245                 250                 255     


Leu Phe Asn Met Val Asp Gly Arg Lys Ile Tyr Glu Gln Glu Gly Leu 
            260                 265                 270         


Glu Lys Tyr Met Glu Tyr Gln Leu Thr Asn Glu Asn Val Ile Leu Thr 
        275                 280                 285             


Pro Gly Pro Ala Phe Arg Phe Val Lys Ala Leu Gln Tyr Val Asn Ala 
    290                 295                 300                 


Arg Leu Arg Asp Leu Tyr Pro Asp Glu Gln Asp Leu Phe Asp Ile Val 
305                 310                 315                 320 


Leu Met Thr Asn Asn His Ala Gln Val Gly Val Arg Leu Ile Asn Ser 
                325                 330                 335     


Val Asn His Tyr Gly Leu Leu Ile Asp Arg Phe Cys Leu Thr Gly Gly 
            340                 345                 350         


Lys Asp Pro Ile Gly Tyr Leu Lys Ala Tyr Leu Thr Asn Leu Tyr Ile 
        355                 360                 365             


Ala Ala Asp Ser Glu Lys Val Gln Glu Ala Ile Gln Glu Gly Ile Ala 
    370                 375                 380                 


Ser Ala Thr Met Phe Asp Gly Ala Lys Asp Met Ala Tyr Cys Asp Thr 
385                 390                 395                 400 


Gln Leu Arg Val Ala Phe Asp Gly Asp Ala Val Leu Phe Ser Asp Glu 
                405                 410                 415     


Ser Glu His Phe Thr Lys Glu His Gly Leu Asp Lys Phe Phe Gln Tyr 
            420                 425                 430         


Asp Thr Leu Cys Glu Ser Lys Pro Leu Ala Gln Gly Pro Leu Lys Gly 
        435                 440                 445             


Phe Leu Glu Asp Leu Gly Arg Leu Gln Lys Lys Phe Tyr Ala Lys Asn 
    450                 455                 460                 


Glu Arg Leu Leu Cys Pro Ile Arg Thr Tyr Leu Val Thr Ala Arg Ser 
465                 470                 475                 480 


Ala Ala Ser Ser Gly Ala Arg Val Leu Lys Thr Leu Arg Arg Trp Gly 
                485                 490                 495     


Leu Glu Ile Asp Glu Ala Leu Phe Leu Ala Gly Ala Pro Lys Ser Pro 
            500                 505                 510         


Ile Leu Val Lys Ile Arg Pro His Ile Phe Phe Asp Asp His Met Phe 
        515                 520                 525             


His Ile Glu Gly Ala Gln Arg Leu Gly Ser Ile Ala Ala Tyr Gly Phe 
    530                 535                 540                 


Asn Lys Lys Phe Ser Ser 
545                 550 

<210>  1424
<211>  3383
<212>  DNA
<213>  Homo sapiens

<400>  1424
attctacact gagtctagcc atggggaagg ggctttgaca gtgtcttcct caacaggttt     60

tgccattgaa agaaacatga gacattaaag ctaaactcaa actcaagtct aaactccatg    120

tctggaacaa aatcccagct gtcaaaaata gtctctagat ctgagaaaag ccctccaaag    180

tctgtctggc agaatgaaca tggataaatg attggatcca caaatgactt tgccattcat    240

tttggcagta ccaggaaaca gacagtcaca aatgggatta atataatgaa tggcagagaa    300

atgcttaaaa agatttaaaa aggaagtggt aatattgata ttgctacata ttgaacattt    360

gaacaatgtt tagacatcaa tttctgaaaa caaagacaat ggctatgagc agatacactc    420

aaaatgaaga aacatttatt ttttgttttt taagaaaagg ttaatcacat attcatagag    480

tcagtttgtt actatggaat cacatatgat gtcataaatt tgacattcta aatgcaaagc    540

tagactgagc aagggaagtg acaggaaatg gagctgggga gacaaaaatg tggataacaa    600

caaaagaatt tcaacaggta aaaaaatgag tcaaacatct ctcaaacaga aaaagaatga    660

gcctggaatg aggtcctcaa aagagagtct agaagcagaa aaaagaaagg aatctgacaa    720

aacaggagtt cgtctgagca atcagatgag gcgtgcagtc aatccgaatc actcgctgag    780

atgttgcccc ttccagggtc actcgtcgtg tagacgctgc ctttgtgcag ctgagggaac    840

agcccttggc ccctgccaca caatacgtat ttatattcac atgtgcctgt tgtgggagca    900

gggccagcag atcaccatga tgaggggatc acaagaatca tcactgcgga agacagactc    960

tcgagggtac cttgtgcgca gtcaatggtc tagaatatcc cggagcccat ccaccaaggc   1020

tccatccata gatgagccta gaagcaggaa caccagtgct aagctcccca gcagctccac   1080

gagctcccgg actccatcca cctccccaag cctgcatgac tcctcaccgc cgccgctgtc   1140

cgggcagccc tcgctccagc cacccgcgtc gccccagctg ccccggtcgc tggactcgcg   1200

gcctcccacg cccccagagc ccgatcctgg ctcccggcgc agcaccaaaa tgcaagagaa   1260

tccggaggcc tgggcccaag gcatcgtgcg ggaaatccgc cagacccggg actcgcagcc   1320

gctggaatat tcgcgcacgt cccccaccga gtggaagtcc tccagccagc gcagggggat   1380

ctaccccgcc tccacccagc tggaccgcaa ctctctgtcc gagcagcagc agcagcagcg   1440

ggaggacgag gacgactacg aggctgccta ctgggcatcc atgaggtcgt tctacgagaa   1500

gaacccgagc tgctcgcgcc cctggccgcc caaacccaag aacgccatca ccattgctct   1560

ctcatcctgc gcgctcttca acatggtgga cggcaggaaa atctacgagc aagagggtct   1620

ggaaaagtac atggagtatc agctcaccaa tgagaacgtc atcctgaccc cgggcccggc   1680

gttccgcttc gtcaaggcac tacagtatgt caatgctaga ctccgtgatc tatatcctga   1740

tgaacaggac ttatttgata ttgtactgat gactaataac catgcccaag tgggagtgcg   1800

gcttataaac agcgtcaatc actacggctt actgattgac cgcttctgtc tgaccggggg   1860

aaaagacccc attggctatt tgaaggcata tcttaccaac ttgtatattg ctgcagattc   1920

tgaaaaagtg caagaggcaa tacaagaagg tattgcctct gcgacaatgt ttgatggagc   1980

caaagacatg gcttactgtg acactcagct ccgtgtagcc tttgatgggg atgctgtcct   2040

cttctctgat gagtctgaac attttaccaa ggagcatggg ctcgacaaat tcttccagta   2100

tgatacatta tgtgaaagta agcctcttgc tcagggtccc ctaaaaggct ttctggaaga   2160

tttaggcaga ctgcaaaaga agttctatgc caaaaatgaa cggttacttt gtcctatcag   2220

gacctacctg gttacagcta ggagtgcagc cagttcaggc gcccgtgtgc tgaagaccct   2280

tcgacgctgg ggtctagaga tagacgaagc tcttttcctt gctggagccc ccaaaagtcc   2340

catcttggtg aagatccggc cccacatctt ctttgatgac cacatgttcc acattgaagg   2400

ggcacagagg ttaggttcca tcgcagctta tggctttaat aaaaaattca gtagttaggg   2460

gcagggagga gaaataaagt ggtgatagtc tggtgttaca gaagccactt cttttggctc   2520

tctaggataa ttagataggt atttcagaaa attggacctt aaaactttgc ttctttggaa   2580

aggttttctc ctgatttttt ggaaaacctt ttgaaccctc aagttaccat caaactactt   2640

ctctttgaac taccaatact gttgaatgcc attacaccta tctctgtgta agtcataatg   2700

atgactcttt aggataagtt tagaacttga atatttgcat gcttaaggca ctgttttaga   2760

agcttactta gttttataaa cactgctcat ttttggatgt ttgtagataa caatgaattg   2820

ttacccatca gcattgtaga atagtgtctt caaaggtaga aggagtatgg ttaagcacac   2880

tcttgaaaac tggagctttg tattctgtga ctgctatggc tagctttgta accaaagcaa   2940

aatgagaatt tcactctacc tgcatgagta taacaatttt gatactgctc atttagaaat   3000

aaatcatctg gttgttcctc cagggtactt tctaagataa gccttaaaca gaaaccccta   3060

agaaaggttc tctgaaaatt atttggtggg ttaaatgcct ctgatccaca gagtttcata   3120

tttgaagtct ccggctttgg gcctggcagg ctggcacatc catatttgta tggaaaaaaa   3180

aaaaaaagac cctacgctac cacttcaaaa agtgacatga agtgtagtat cctggccctt   3240

cattgtcatt ctctcatgat ttttgttttg ttttcaacaa aaattggttg gtcattaaat   3300

atatcatatg ttaggcacag tgacctggtt attttcacat gttacttcat tttcttatca   3360

aattaaatgt ttgtgacata gta                                           3383


<210>  1425
<211>  610
<212>  PRT
<213>  Homo sapiens

<400>  1425


Met Ser Gln Thr Ser Leu Lys Gln Lys Lys Asn Glu Pro Gly Met Arg 
1               5                   10                  15      


Ser Ser Lys Glu Ser Leu Glu Ala Glu Lys Arg Lys Glu Ser Asp Lys 
            20                  25                  30          


Thr Gly Val Arg Leu Ser Asn Gln Met Arg Arg Ala Val Asn Pro Asn 
        35                  40                  45              


His Ser Leu Arg Cys Cys Pro Phe Gln Gly His Ser Ser Cys Arg Arg 
    50                  55                  60                  


Cys Leu Cys Ala Ala Glu Gly Thr Ala Leu Gly Pro Cys His Thr Ile 
65                  70                  75                  80  


Arg Ile Tyr Ile His Met Cys Leu Leu Trp Glu Gln Gly Gln Gln Ile 
                85                  90                  95      


Thr Met Met Arg Gly Ser Gln Glu Ser Ser Leu Arg Lys Thr Asp Ser 
            100                 105                 110         


Arg Gly Tyr Leu Val Arg Ser Gln Trp Ser Arg Ile Ser Arg Ser Pro 
        115                 120                 125             


Ser Thr Lys Ala Pro Ser Ile Asp Glu Pro Arg Ser Arg Asn Thr Ser 
    130                 135                 140                 


Ala Lys Leu Pro Ser Ser Ser Thr Ser Ser Arg Thr Pro Ser Thr Ser 
145                 150                 155                 160 


Pro Ser Leu His Asp Ser Ser Pro Pro Pro Leu Ser Gly Gln Pro Ser 
                165                 170                 175     


Leu Gln Pro Pro Ala Ser Pro Gln Leu Pro Arg Ser Leu Asp Ser Arg 
            180                 185                 190         


Pro Pro Thr Pro Pro Glu Pro Asp Pro Gly Ser Arg Arg Ser Thr Lys 
        195                 200                 205             


Met Gln Glu Asn Pro Glu Ala Trp Ala Gln Gly Ile Val Arg Glu Ile 
    210                 215                 220                 


Arg Gln Thr Arg Asp Ser Gln Pro Leu Glu Tyr Ser Arg Thr Ser Pro 
225                 230                 235                 240 


Thr Glu Trp Lys Ser Ser Ser Gln Arg Arg Gly Ile Tyr Pro Ala Ser 
                245                 250                 255     


Thr Gln Leu Asp Arg Asn Ser Leu Ser Glu Gln Gln Gln Gln Gln Arg 
            260                 265                 270         


Glu Asp Glu Asp Asp Tyr Glu Ala Ala Tyr Trp Ala Ser Met Arg Ser 
        275                 280                 285             


Phe Tyr Glu Lys Asn Pro Ser Cys Ser Arg Pro Trp Pro Pro Lys Pro 
    290                 295                 300                 


Lys Asn Ala Ile Thr Ile Ala Leu Ser Ser Cys Ala Leu Phe Asn Met 
305                 310                 315                 320 


Val Asp Gly Arg Lys Ile Tyr Glu Gln Glu Gly Leu Glu Lys Tyr Met 
                325                 330                 335     


Glu Tyr Gln Leu Thr Asn Glu Asn Val Ile Leu Thr Pro Gly Pro Ala 
            340                 345                 350         


Phe Arg Phe Val Lys Ala Leu Gln Tyr Val Asn Ala Arg Leu Arg Asp 
        355                 360                 365             


Leu Tyr Pro Asp Glu Gln Asp Leu Phe Asp Ile Val Leu Met Thr Asn 
    370                 375                 380                 


Asn His Ala Gln Val Gly Val Arg Leu Ile Asn Ser Val Asn His Tyr 
385                 390                 395                 400 


Gly Leu Leu Ile Asp Arg Phe Cys Leu Thr Gly Gly Lys Asp Pro Ile 
                405                 410                 415     


Gly Tyr Leu Lys Ala Tyr Leu Thr Asn Leu Tyr Ile Ala Ala Asp Ser 
            420                 425                 430         


Glu Lys Val Gln Glu Ala Ile Gln Glu Gly Ile Ala Ser Ala Thr Met 
        435                 440                 445             


Phe Asp Gly Ala Lys Asp Met Ala Tyr Cys Asp Thr Gln Leu Arg Val 
    450                 455                 460                 


Ala Phe Asp Gly Asp Ala Val Leu Phe Ser Asp Glu Ser Glu His Phe 
465                 470                 475                 480 


Thr Lys Glu His Gly Leu Asp Lys Phe Phe Gln Tyr Asp Thr Leu Cys 
                485                 490                 495     


Glu Ser Lys Pro Leu Ala Gln Gly Pro Leu Lys Gly Phe Leu Glu Asp 
            500                 505                 510         


Leu Gly Arg Leu Gln Lys Lys Phe Tyr Ala Lys Asn Glu Arg Leu Leu 
        515                 520                 525             


Cys Pro Ile Arg Thr Tyr Leu Val Thr Ala Arg Ser Ala Ala Ser Ser 
    530                 535                 540                 


Gly Ala Arg Val Leu Lys Thr Leu Arg Arg Trp Gly Leu Glu Ile Asp 
545                 550                 555                 560 


Glu Ala Leu Phe Leu Ala Gly Ala Pro Lys Ser Pro Ile Leu Val Lys 
                565                 570                 575     


Ile Arg Pro His Ile Phe Phe Asp Asp His Met Phe His Ile Glu Gly 
            580                 585                 590         


Ala Gln Arg Leu Gly Ser Ile Ala Ala Tyr Gly Phe Asn Lys Lys Phe 
        595                 600                 605             


Ser Ser 
    610 

<210>  1426
<211>  3021
<212>  DNA
<213>  Homo sapiens

<400>  1426
attctacact gagtctagcc atggggaagg ggctttgaca gtgtcttcct caacaggttt     60

tgccattgaa agaaacatga gacattaaag ctaaactcaa actcaagtct aaactccatg    120

tctggaacaa aatcccagct gtcaaaaata gtctctagat ctgagaaaag ccctccaaag    180

tctgtctggc agaatgaaca tggataaatg attggatcca caaatgactt tgccattcat    240

tttggcagta ccaggaaaca gacagtcaca aatgggatta atataatgaa tggcagagaa    300

atgcttaaaa agatttaaaa aggaagtggt aatattgata ttgctacata ttgaacattt    360

gaacaatgtt tagacatcaa tttctgaaaa caaagacaat ggctatgagc agatacactc    420

aaaatgaaga aacatttatt ttttgttttt taagaaaagg ttaatcacat attcatagag    480

tcagtttgtt actatggaat cacatatgat gtcataaatt tgacattcta aatgcaaagc    540

tagactgagc aagggaagtg acaggaaatg gagctgggga gacaaaaatg tggataacaa    600

caaaagaatt tcaacaggta aaaaaatgag tcaaacatct ctcaaacaga aaaagaatga    660

gcctggaatg aggtcctcaa aagagagtct agaagcagaa aaaagaaagg aatctgacaa    720

aacaggagtt cgtctgagca atcagatgag gcgtgcagtc aatccgaatc actcgctgag    780

atgttgcccc ttccagggtc actcgtcgtg tagacgctgc ctttgtgcag ctgagggaac    840

agcccttggc ccctgccaca caatacgtat ttatattcac atgtgcctgt tgtgggagca    900

gggccagcag atcaccatga tgaggggatc acaagaatca tcactgcgga agacagactc    960

tcgagggtac cttgtgcgca gtcaatggtc tagaatatcc cggagcccat ccaccaaggc   1020

tccatccata gatgagccta gaagcaggaa caccagtgct aagctcccca gcagctccac   1080

gagctcccgg actccatcca cctccccaag cctgcatgac tcctcaccgc cgccgctgtc   1140

cgggcagccc tcgctccagc cacccgcgtc gccccagctg ccccggtcgc tggactcgcg   1200

gcctcccacg cccccagagc ccgatcctgg ctcccggcgc agcaccaaaa tgcaagagaa   1260

tccggaggcc tgggcccaag gcatcgtgcg ggaaatccgc cagacccggg actcgcagcc   1320

gctggaatat tcgcgcacgt cccccaccga gtggaagtcc tccagccagc gcagggggat   1380

ctaccccgcc tccacccagc tggaccgcaa ctctctgtcc gagcagcagc agcagcagcg   1440

ggaggacgag gacgactacg aggctgccta ctgggcatcc atgaggtcgt tctacgagaa   1500

gaacccgagc tgctcgcgcc cctggccgcc caaacccaag aacgccatca ccattgctct   1560

ctcatcctgc gcgctcttca acatggtgga cggcaggaaa atctacgagc aagagggtct   1620

ggaaaagtac atggagtatc agctcaccaa tgagaacgtc atcctgaccc cgggcccggc   1680

gttccgcttc gtcaaggcac tacagtatgt caatgctaga ctccgtgatc tatatcctga   1740

tgaacaggac ttatttgata ttgtactgat gactaataac catgcccaag tgggagtgcg   1800

gcttataaac agcgtcaatc actacggctt actgattgac cgcttctgtc tgaccggggg   1860

aaaagacccc attggctatt tgaaggcata tcttaccaac ttgtatattg ctgcagattc   1920

tgaaaaagtg caagaggcaa tacaagaagg tattgcctct gcgacaatgt ttgatggagc   1980

caaagacatg gcttactgtg acactcagct ccgtgtagcc tttgatgggg atgctgtcct   2040

cttctctgat gagtctgaac attttaccaa ggagcatggg ctcgacaaat tcttccagta   2100

tgatacatta tgtgaaagta agcctcttgc tcagggtccc ctaaaaggct ttctggaaga   2160

tttaggcaga ctgcaaaaga agttctatgc caaaaatgaa cggttacttt gtcctatcag   2220

gacctacctg gttacagcta ggagtgcagc cagttcaggc gcccgtgtgc tgaagaccct   2280

tcgacgctgg ggtctagaga tagacgaagc tcttttcctt gctggagccc ccaaaagtcc   2340

catcttggtg aagatccggc cccacatctt ctttgatgac cacatgttcc acattgaagg   2400

ggcacagagg ttaggttcca tcgcagctta tggctttaat aaaaaattca gtagttaggg   2460

gcagggagga gaaataaagt ggtgatagtc tggtgttaca gaagccactt cttttggctc   2520

tctaggataa ttagataggt atttcagaaa attggacctt aaaactttgc ttctttggaa   2580

aggttttctc ctgatttttt ggaaaacctt ttgaaccctc aagttaccat caaactactt   2640

ctctttgaac taccaatact gttgaatgcc attacaccta tctctgtgta agtcataatg   2700

atgactcttt aggataagtt tagaacttga atatttgcat gcttaaggca ctgttttaga   2760

agcttactta gttttataaa cactgctcat ttttggatgt ttgtagataa caatgaattg   2820

ttacccatca gcattgtaga atagtgtctt caaaggtaga aggagtatgg ttaagcacac   2880

tcttgaaaac tggagctttg tattctgtga ctgctatggc tagctttgta accaaagcaa   2940

aatgagaatt tcactctacc tgcatgagta taacaatttt gatactgctc atttagaaat   3000

aaatcatctg gttgttcctc c                                             3021


<210>  1427
<211>  610
<212>  PRT
<213>  Homo sapiens

<400>  1427


Met Ser Gln Thr Ser Leu Lys Gln Lys Lys Asn Glu Pro Gly Met Arg 
1               5                   10                  15      


Ser Ser Lys Glu Ser Leu Glu Ala Glu Lys Arg Lys Glu Ser Asp Lys 
            20                  25                  30          


Thr Gly Val Arg Leu Ser Asn Gln Met Arg Arg Ala Val Asn Pro Asn 
        35                  40                  45              


His Ser Leu Arg Cys Cys Pro Phe Gln Gly His Ser Ser Cys Arg Arg 
    50                  55                  60                  


Cys Leu Cys Ala Ala Glu Gly Thr Ala Leu Gly Pro Cys His Thr Ile 
65                  70                  75                  80  


Arg Ile Tyr Ile His Met Cys Leu Leu Trp Glu Gln Gly Gln Gln Ile 
                85                  90                  95      


Thr Met Met Arg Gly Ser Gln Glu Ser Ser Leu Arg Lys Thr Asp Ser 
            100                 105                 110         


Arg Gly Tyr Leu Val Arg Ser Gln Trp Ser Arg Ile Ser Arg Ser Pro 
        115                 120                 125             


Ser Thr Lys Ala Pro Ser Ile Asp Glu Pro Arg Ser Arg Asn Thr Ser 
    130                 135                 140                 


Ala Lys Leu Pro Ser Ser Ser Thr Ser Ser Arg Thr Pro Ser Thr Ser 
145                 150                 155                 160 


Pro Ser Leu His Asp Ser Ser Pro Pro Pro Leu Ser Gly Gln Pro Ser 
                165                 170                 175     


Leu Gln Pro Pro Ala Ser Pro Gln Leu Pro Arg Ser Leu Asp Ser Arg 
            180                 185                 190         


Pro Pro Thr Pro Pro Glu Pro Asp Pro Gly Ser Arg Arg Ser Thr Lys 
        195                 200                 205             


Met Gln Glu Asn Pro Glu Ala Trp Ala Gln Gly Ile Val Arg Glu Ile 
    210                 215                 220                 


Arg Gln Thr Arg Asp Ser Gln Pro Leu Glu Tyr Ser Arg Thr Ser Pro 
225                 230                 235                 240 


Thr Glu Trp Lys Ser Ser Ser Gln Arg Arg Gly Ile Tyr Pro Ala Ser 
                245                 250                 255     


Thr Gln Leu Asp Arg Asn Ser Leu Ser Glu Gln Gln Gln Gln Gln Arg 
            260                 265                 270         


Glu Asp Glu Asp Asp Tyr Glu Ala Ala Tyr Trp Ala Ser Met Arg Ser 
        275                 280                 285             


Phe Tyr Glu Lys Asn Pro Ser Cys Ser Arg Pro Trp Pro Pro Lys Pro 
    290                 295                 300                 


Lys Asn Ala Ile Thr Ile Ala Leu Ser Ser Cys Ala Leu Phe Asn Met 
305                 310                 315                 320 


Val Asp Gly Arg Lys Ile Tyr Glu Gln Glu Gly Leu Glu Lys Tyr Met 
                325                 330                 335     


Glu Tyr Gln Leu Thr Asn Glu Asn Val Ile Leu Thr Pro Gly Pro Ala 
            340                 345                 350         


Phe Arg Phe Val Lys Ala Leu Gln Tyr Val Asn Ala Arg Leu Arg Asp 
        355                 360                 365             


Leu Tyr Pro Asp Glu Gln Asp Leu Phe Asp Ile Val Leu Met Thr Asn 
    370                 375                 380                 


Asn His Ala Gln Val Gly Val Arg Leu Ile Asn Ser Val Asn His Tyr 
385                 390                 395                 400 


Gly Leu Leu Ile Asp Arg Phe Cys Leu Thr Gly Gly Lys Asp Pro Ile 
                405                 410                 415     


Gly Tyr Leu Lys Ala Tyr Leu Thr Asn Leu Tyr Ile Ala Ala Asp Ser 
            420                 425                 430         


Glu Lys Val Gln Glu Ala Ile Gln Glu Gly Ile Ala Ser Ala Thr Met 
        435                 440                 445             


Phe Asp Gly Ala Lys Asp Met Ala Tyr Cys Asp Thr Gln Leu Arg Val 
    450                 455                 460                 


Ala Phe Asp Gly Asp Ala Val Leu Phe Ser Asp Glu Ser Glu His Phe 
465                 470                 475                 480 


Thr Lys Glu His Gly Leu Asp Lys Phe Phe Gln Tyr Asp Thr Leu Cys 
                485                 490                 495     


Glu Ser Lys Pro Leu Ala Gln Gly Pro Leu Lys Gly Phe Leu Glu Asp 
            500                 505                 510         


Leu Gly Arg Leu Gln Lys Lys Phe Tyr Ala Lys Asn Glu Arg Leu Leu 
        515                 520                 525             


Cys Pro Ile Arg Thr Tyr Leu Val Thr Ala Arg Ser Ala Ala Ser Ser 
    530                 535                 540                 


Gly Ala Arg Val Leu Lys Thr Leu Arg Arg Trp Gly Leu Glu Ile Asp 
545                 550                 555                 560 


Glu Ala Leu Phe Leu Ala Gly Ala Pro Lys Ser Pro Ile Leu Val Lys 
                565                 570                 575     


Ile Arg Pro His Ile Phe Phe Asp Asp His Met Phe His Ile Glu Gly 
            580                 585                 590         


Ala Gln Arg Leu Gly Ser Ile Ala Ala Tyr Gly Phe Asn Lys Lys Phe 
        595                 600                 605             


Ser Ser 
    610 

<210>  1428
<211>  2841
<212>  DNA
<213>  Homo sapiens

<400>  1428
attctacact gagtctagcc atggggaagg ggctttgaca gtgtcttcct caacaggttt     60

tgccattgaa agaaacatga gacattaaag ctaaactcaa actcaagtct aaactccatg    120

tctggaacaa aatcccagct gtcaaaaata gtctctagat ctgagaaaag ccctccaaag    180

tctgtctggc agaatgaaca tggataaatg attggatcca caaatgactt tgccattcat    240

tttggcagta ccaggaaaca gacagtcaca aatgggatta atataatgaa tggcagagaa    300

atgcttaaaa agatttaaaa aggaagtggt aatattgata ttgctacata ttgaacattt    360

gaacaatgtt tagacatcaa tttctgaaaa caaagacaat ggctatgagc agatacactc    420

aaaatgaaga aacatttatt ttttgttttt taagaaaagg ttaatcacat attcatagag    480

tcagtttgtt actatggaat cacatatgat gtcataaatt tgacattcta aatgcaaagc    540

tagactgagc aagggaagtg acaggaaatg gagctgggga gacaaaaatg tggataacaa    600

caaaagaatt tcaacaggta aaaaaatgag tcaaacatct ctcaaacaga aaaagaatga    660

gcctggaatg aggtcctcaa aagagagtct agaagcagaa aaaagaaagg aatctgacaa    720

aacaggagtt cgtctgagca atcagggatc acaagaatca tcactgcgga agacagactc    780

tcgagggtac cttgtgcgca gtcaatggtc tagaatatcc cggagcccat ccaccaaggc    840

tccatccata gatgagccta gaagcaggaa caccagtgct aagctcccca gcagctccac    900

gagctcccgg actccatcca cctccccaag cctgcatgac tcctcaccgc cgccgctgtc    960

cgggcagccc tcgctccagc cacccgcgtc gccccagctg ccccggtcgc tggactcgcg   1020

gcctcccacg cccccagagc ccgatcctgg ctcccggcgc agcaccaaaa tgcaagagaa   1080

tccggaggcc tgggcccaag gcatcgtgcg ggaaatccgc cagacccggg actcgcagcc   1140

gctggaatat tcgcgcacgt cccccaccga gtggaagtcc tccagccagc gcagggggat   1200

ctaccccgcc tccacccagc tggaccgcaa ctctctgtcc gagcagcagc agcagcagcg   1260

ggaggacgag gacgactacg aggctgccta ctgggcatcc atgaggtcgt tctacgagaa   1320

gaacccgagc tgctcgcgcc cctggccgcc caaacccaag aacgccatca ccattgctct   1380

ctcatcctgc gcgctcttca acatggtgga cggcaggaaa atctacgagc aagagggtct   1440

ggaaaagtac atggagtatc agctcaccaa tgagaacgtc atcctgaccc cgggcccggc   1500

gttccgcttc gtcaaggcac tacagtatgt caatgctaga ctccgtgatc tatatcctga   1560

tgaacaggac ttatttgata ttgtactgat gactaataac catgcccaag tgggagtgcg   1620

gcttataaac agcgtcaatc actacggctt actgattgac cgcttctgtc tgaccggggg   1680

aaaagacccc attggctatt tgaaggcata tcttaccaac ttgtatattg ctgcagattc   1740

tgaaaaagtg caagaggcaa tacaagaagg tattgcctct gcgacaatgt ttgatggagc   1800

caaagacatg gcttactgtg acactcagct ccgtgtagcc tttgatgggg atgctgtcct   1860

cttctctgat gagtctgaac attttaccaa ggagcatggg ctcgacaaat tcttccagta   1920

tgatacatta tgtgaaagta agcctcttgc tcagggtccc ctaaaaggct ttctggaaga   1980

tttaggcaga ctgcaaaaga agttctatgc caaaaatgaa cggttacttt gtcctatcag   2040

gacctacctg gttacagcta ggagtgcagc cagttcaggc gcccgtgtgc tgaagaccct   2100

tcgacgctgg ggtctagaga tagacgaagc tcttttcctt gctggagccc ccaaaagtcc   2160

catcttggtg aagatccggc cccacatctt ctttgatgac cacatgttcc acattgaagg   2220

ggcacagagg ttaggttcca tcgcagctta tggctttaat aaaaaattca gtagttaggg   2280

gcagggagga gaaataaagt ggtgatagtc tggtgttaca gaagccactt cttttggctc   2340

tctaggataa ttagataggt atttcagaaa attggacctt aaaactttgc ttctttggaa   2400

aggttttctc ctgatttttt ggaaaacctt ttgaaccctc aagttaccat caaactactt   2460

ctctttgaac taccaatact gttgaatgcc attacaccta tctctgtgta agtcataatg   2520

atgactcttt aggataagtt tagaacttga atatttgcat gcttaaggca ctgttttaga   2580

agcttactta gttttataaa cactgctcat ttttggatgt ttgtagataa caatgaattg   2640

ttacccatca gcattgtaga atagtgtctt caaaggtaga aggagtatgg ttaagcacac   2700

tcttgaaaac tggagctttg tattctgtga ctgctatggc tagctttgta accaaagcaa   2760

aatgagaatt tcactctacc tgcatgagta taacaatttt gatactgctc atttagaaat   2820

aaatcatctg gttgttcctc c                                             2841


<210>  1429
<211>  550
<212>  PRT
<213>  Homo sapiens

<400>  1429


Met Ser Gln Thr Ser Leu Lys Gln Lys Lys Asn Glu Pro Gly Met Arg 
1               5                   10                  15      


Ser Ser Lys Glu Ser Leu Glu Ala Glu Lys Arg Lys Glu Ser Asp Lys 
            20                  25                  30          


Thr Gly Val Arg Leu Ser Asn Gln Gly Ser Gln Glu Ser Ser Leu Arg 
        35                  40                  45              


Lys Thr Asp Ser Arg Gly Tyr Leu Val Arg Ser Gln Trp Ser Arg Ile 
    50                  55                  60                  


Ser Arg Ser Pro Ser Thr Lys Ala Pro Ser Ile Asp Glu Pro Arg Ser 
65                  70                  75                  80  


Arg Asn Thr Ser Ala Lys Leu Pro Ser Ser Ser Thr Ser Ser Arg Thr 
                85                  90                  95      


Pro Ser Thr Ser Pro Ser Leu His Asp Ser Ser Pro Pro Pro Leu Ser 
            100                 105                 110         


Gly Gln Pro Ser Leu Gln Pro Pro Ala Ser Pro Gln Leu Pro Arg Ser 
        115                 120                 125             


Leu Asp Ser Arg Pro Pro Thr Pro Pro Glu Pro Asp Pro Gly Ser Arg 
    130                 135                 140                 


Arg Ser Thr Lys Met Gln Glu Asn Pro Glu Ala Trp Ala Gln Gly Ile 
145                 150                 155                 160 


Val Arg Glu Ile Arg Gln Thr Arg Asp Ser Gln Pro Leu Glu Tyr Ser 
                165                 170                 175     


Arg Thr Ser Pro Thr Glu Trp Lys Ser Ser Ser Gln Arg Arg Gly Ile 
            180                 185                 190         


Tyr Pro Ala Ser Thr Gln Leu Asp Arg Asn Ser Leu Ser Glu Gln Gln 
        195                 200                 205             


Gln Gln Gln Arg Glu Asp Glu Asp Asp Tyr Glu Ala Ala Tyr Trp Ala 
    210                 215                 220                 


Ser Met Arg Ser Phe Tyr Glu Lys Asn Pro Ser Cys Ser Arg Pro Trp 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asn Ala Ile Thr Ile Ala Leu Ser Ser Cys Ala 
                245                 250                 255     


Leu Phe Asn Met Val Asp Gly Arg Lys Ile Tyr Glu Gln Glu Gly Leu 
            260                 265                 270         


Glu Lys Tyr Met Glu Tyr Gln Leu Thr Asn Glu Asn Val Ile Leu Thr 
        275                 280                 285             


Pro Gly Pro Ala Phe Arg Phe Val Lys Ala Leu Gln Tyr Val Asn Ala 
    290                 295                 300                 


Arg Leu Arg Asp Leu Tyr Pro Asp Glu Gln Asp Leu Phe Asp Ile Val 
305                 310                 315                 320 


Leu Met Thr Asn Asn His Ala Gln Val Gly Val Arg Leu Ile Asn Ser 
                325                 330                 335     


Val Asn His Tyr Gly Leu Leu Ile Asp Arg Phe Cys Leu Thr Gly Gly 
            340                 345                 350         


Lys Asp Pro Ile Gly Tyr Leu Lys Ala Tyr Leu Thr Asn Leu Tyr Ile 
        355                 360                 365             


Ala Ala Asp Ser Glu Lys Val Gln Glu Ala Ile Gln Glu Gly Ile Ala 
    370                 375                 380                 


Ser Ala Thr Met Phe Asp Gly Ala Lys Asp Met Ala Tyr Cys Asp Thr 
385                 390                 395                 400 


Gln Leu Arg Val Ala Phe Asp Gly Asp Ala Val Leu Phe Ser Asp Glu 
                405                 410                 415     


Ser Glu His Phe Thr Lys Glu His Gly Leu Asp Lys Phe Phe Gln Tyr 
            420                 425                 430         


Asp Thr Leu Cys Glu Ser Lys Pro Leu Ala Gln Gly Pro Leu Lys Gly 
        435                 440                 445             


Phe Leu Glu Asp Leu Gly Arg Leu Gln Lys Lys Phe Tyr Ala Lys Asn 
    450                 455                 460                 


Glu Arg Leu Leu Cys Pro Ile Arg Thr Tyr Leu Val Thr Ala Arg Ser 
465                 470                 475                 480 


Ala Ala Ser Ser Gly Ala Arg Val Leu Lys Thr Leu Arg Arg Trp Gly 
                485                 490                 495     


Leu Glu Ile Asp Glu Ala Leu Phe Leu Ala Gly Ala Pro Lys Ser Pro 
            500                 505                 510         


Ile Leu Val Lys Ile Arg Pro His Ile Phe Phe Asp Asp His Met Phe 
        515                 520                 525             


His Ile Glu Gly Ala Gln Arg Leu Gly Ser Ile Ala Ala Tyr Gly Phe 
    530                 535                 540                 


Asn Lys Lys Phe Ser Ser 
545                 550 

<210>  1430
<211>  3267
<212>  DNA
<213>  Homo sapiens

<400>  1430
agactccaaa atggcagccg cgcagagcgc gcacccaagc ggccggacct ccccgactcc     60

cgggccgccc ccgtctcgcg ccctgcctcc ctccttcggc cttcacctac ccgcctccgg    120

attggccgct aggaatcccg cccctctaaa gccctgcctg ctattggtca cgattttata    180

atcaatggat aaagtgggaa aaatgtggaa taacttcaaa tacaggtgtc agaatctctt    240

cggtcatgag ggaggaagcc gtagtgaaaa tgtggacatg aactccaaca gatgtttgtc    300

tgtcaaagag aaaaacatca gcataggaga ctcaactcct cagcaacaaa gcagtccctt    360

aagagaaaat attgccttac aactgggatt aagcccttcg aagaattctt caaggagaaa    420

tcaaaattgt gccacagaaa tccctcaaat tgttgaaata agcatcgaaa aggataatga    480

ttcttgtgtt accccaggaa caagacttgc acgaagagat tcctactctc gacatgctcc    540

atggggtggg aagaaaaaac attcctgttc tacaaagacc cagagttcat tggatgctga    600

taaaaagttt ggtagaactc gaagtggact tcaaaggaga gagaggcgct acggcgtaag    660

ttctgtacac gacatggaca gtgtttccag cagaactgta ggaagtcgct ctctaagaca    720

gaggttgcag gatactgtgg gcttgtgttt tcccatgaga acttacagca agcagtcaaa    780

gcctctcttt tccaataaaa gaaaaatcca tctctctgaa ttaatgcttg agaaatgccc    840

ttttcctgct ggctcagatt tagcccaaaa atggcatttg attaaacagc atacagctcc    900

tgtgagccca cattcaacat tttttgatac atttgatcca tctttggttt ctacagaaga    960

tgaagaagat aggcttagag agagaaggcg gcttagtatt gaagaagggg ttgatccccc   1020

tcccaatgca caaatacata catttgaagc tactgcacag gttaatccat tatataaact   1080

gggaccaaaa ttagctcctg gaatgactga aataagtggg gacagttctg caattccaca   1140

agctaattgt gactcggaag aggatacaac caccctgtgt ttgcagtcac ggaggcagaa   1200

gcagcgtcag atatctggag acagccatac ccatgttagc agacagggag cttggaaagt   1260

ccacacacag attgattaca tacactgcct cgtgcctgat ttgcttcaaa ttacagggaa   1320

tccctgttac tggggagtga tggaccgtta tgaagcagaa gcccttctcg aagggaaacc   1380

tgaaggcacg tttttgctca gggactctgc gcaagaggac tacctcttct ctgtgagctt   1440

ccgccgctac aacagatccc tgcatgcccg aattgagcag tggaatcaca actttagttt   1500

cgacgcccat gacccgtgtg tatttcactc ctccactgta acgggacttt tagaacatta   1560

taaagatccc agttcgtgca tgttttttga accattgctt actatatcac taaataggac   1620

tttccctttt agcctgcagt atatctgtcg cgcggtaatc tgcaggtgca ctacgtatga   1680

tggaattgat gggctccctc taccctcaat gttacaggat tttttaaaag agtatcatta   1740

taaacaaaaa gttagagttc gctggttgga acgagaacca gtcaaggcaa agtaaactct   1800

ccggtcccca aaggttgtta actaggtccg ctttcatgtg catcagacag tacacctata   1860

gcaagcacac gtagcagtgt taggcttttt catacagtat gtaagcttag tgttagtatc   1920

tgtcagatgc tacctgctgt tacttattca gataaacatg gtgcctattg gaacaatagc   1980

ggatagagct acaggtgttc agtaagacta caaaaacatt ttgcctattt cgctaacagt   2040

ttggttttta atggctgtgg tatttgagtg aggcaactct ggggcatttg ttatgaagaa   2100

ttctatttct tactgaagaa caaattatta atattggatg agtatttcaa cagtgtgact   2160

aatgtttgaa attatttttt ctaagagttt ttctataacc ttccaaaagt cgtgatgttt   2220

gtagttacta taaatcaagc tttggaagtc caaaaagaat aaaagactgc cttcctttta   2280

gaaaaaaatg caattttctg gccacaaggg catagtgcag ttcacttacg tgttgatgta   2340

gtttataatc agacgccttt tctcttctgc aaaaggtact gttaagtaaa ccagattttc   2400

taaataggca ttcttaaaat ttcagactta caaagctagt agtagaattt tattgaaagg   2460

cctaggtatt aattttttaa atgagtgctt taacttaaaa caggcgtttg gaatagctgc   2520

tgcaatgtag tcttgtgtgt gatttttttt taagttgatg tgcagtctaa ttgttgtttc   2580

ataaaagttg gatctgttcc tatgcccagg atgattttgt gaaccgtgaa gtacgtgaga   2640

ctagaagacg cccaaacaag tcagataata gtaactacaa tggttgctga tgttgagatt   2700

attgttgaac tataattaat aatttggatg gcagaattta tctctttttt gtaaactctc   2760

ataactgaat tgcttaagta taatttatag aatttcagtg cagttcattc ttaatggaaa   2820

atctgaaacc taaattgcag atttaaaagg tactgtacaa ccattatatc tgtaaataac   2880

ttagcacctt tttgtcactt agaataatat gtactactac ttgagtgagc gcttttggaa   2940

gttatatcaa gttctagtgt ttgcttctta gtaactgaac tgaatttaca gttctgtcct   3000

agacattttg cactaaagta gccgaatcca ctctcatgtc ttttcgttaa tgtgctctgt   3060

accactggtg agtgctccat agtttcctta cctgctgcta cagaatgtta ttttacatcc   3120

ctatggctat tgccaaggct acaaaaaagg aaagctatat ttgtatgcaa cactaacctt   3180

ttgactgcta atgtatgttt ctgcttgctg tgccttgtta tggctgcttt ttttgtgcta   3240

ataaagtatg tttggtgttc tccttgt                                       3267


<210>  1431
<211>  56
<212>  PRT
<213>  Homo sapiens

<400>  1431


Met Ala Ala Ala Gln Ser Ala His Pro Ser Gly Arg Thr Ser Pro Thr 
1               5                   10                  15      


Pro Gly Pro Pro Pro Ser Arg Ala Leu Pro Pro Ser Phe Gly Leu His 
            20                  25                  30          


Leu Pro Ala Ser Gly Leu Ala Ala Arg Asn Pro Ala Pro Leu Lys Pro 
        35                  40                  45              


Cys Leu Leu Leu Val Thr Ile Leu 
    50                  55      

<210>  1432
<211>  3957
<212>  DNA
<213>  Homo sapiens

<400>  1432
agactccaaa atggcagccg cgcagagcgc gcacccaagc ggccggacct ccccgactcc     60

cgggccgccc ccgtctcgcg ccctgcctcc ctccttcggc cttcacctac ccgcctccgg    120

attggccgct aggaatcccg cccctctaaa gccctgcctg ctattggtca cgattttata    180

atcaatggat aaagtgggaa aaatgtggaa taacttcaaa tacaggtgtc agaatctctt    240

cggtcatgag ggaggaagcc gtagtgaaaa tgtggacatg aactccaaca gatgtttgtc    300

tgtcaaagag aaaaacatca gcataggaga ctcaactcct cagcaacaaa gcagtccctt    360

aagagaaaat attgccttac aactgggatt aagcccttcg aagaattctt caaggagaaa    420

tcaaaattgt gccacagaaa tccctcaaat tgttgaaata agcatcgaaa aggataatga    480

ttcttgtgtt accccaggaa caagacttgc acgaagagat tcctactctc gacatgctcc    540

atggggtggg aagaaaaaac attcctgttc tacaaagacc cagagttcat tggatgctga    600

taaaaagttt ggtagaactc gaagtggact tcaaaggaga gagaggcgct acggcgtaag    660

ttctgtacac gacatggaca gtgtttccag cagaactgta ggaagtcgct ctctaagaca    720

gaggttgcag gatactgtgg gcttgtgttt tcccatgaga acttacagca agcagtcaaa    780

gcctctcttt tccaataaaa gaaaaatcca tctctctgaa ttaatgcttg agaaatgccc    840

ttttcctgct ggctcagatt tagcccaaaa atggcatttg attaaacagc atacagctcc    900

tgtgagccca cattcaacat tttttgatac atttgatcca tctttggttt ctacagaaga    960

tgaagaagat aggcttagag agagaaggcg gcttagtatt gaagaagggg ttgatccccc   1020

tcccaatgca caaatacata catttgaagc tactgcacag gttaatccat tatataaact   1080

gggaccaaaa ttagctcctg gaatgactga aataagtggg gacagttctg caattccaca   1140

agctaattgt gactcggaag aggatacaac caccctgtgt ttgcagtcac ggaggcagaa   1200

gcagcgtcag atatctggag acagccatac ccatgttagc agacagggag cttggaaagt   1260

ccacacacag attgattaca tacactgcct cgtgcctgat ttgcttcaaa ttacagggaa   1320

tccctgttac tggggagtga tggaccgtta tgaagcagaa gcccttctcg aagggaaacc   1380

tgaaggcacg tttttgctca gggactctgc gcaagaggac tacctcttct ctgtgagctt   1440

ccgccgctac aacagatccc tgcatgcccg aattgagcag tggaatcaca actttagttt   1500

cgacgcccat gacccgtgtg tatttcactc ctccactgta acgggacttt tagaacatta   1560

taaagatccc agttcgtgca tgttttttga accattgctt actatatcac taaataggac   1620

tttccctttt agcctgcagt atatctgtcg cgcggtaatc tgcaggtgca ctacgtatga   1680

tggaattgat gggctccctc taccctcaat gttacaggat tttttaaaag agtatcatta   1740

taaacaaaaa gttagagttc gctggttgga acgagaacca gtcaaggcaa agtaaactct   1800

ccggtcccca aaggttgtta actaggtccg ctttcatgtg catcagacag tacacctata   1860

gcaagcacac gtagcagtgt taggcttttt catacagtat gtaagcttag tgttagtatc   1920

tgtcagatgc tacctgctgt tacttattca gataaacatg gtgcctattg gaacaatagc   1980

ggatagagct acaggtgttc agtaagacta caaaaacatt ttgcctattt cgctaacagt   2040

ttggttttta atggctgtgg tatttgagtg aggcaactct ggggcatttg ttatgaagaa   2100

ttctatttct tactgaagaa caaattatta atattggatg agtatttcaa cagtgtgact   2160

aatgtttgaa attatttttt ctaagagttt ttctataacc ttccaaaagt cgtgatgttt   2220

gtagttacta taaatcaagc tttggaagtc caaaaagaat aaaagactgc cttcctttta   2280

gaaaaaaatg caattttctg gccacaaggg catagtgcag ttcacttacg tgttgatgta   2340

gtttataatc agacgccttt tctcttctgc aaaaggtact gttaagtaaa ccagattttc   2400

taaataggca ttcttaaaat ttcagactta caaagctagt agtagaattt tattgaaagg   2460

cctaggtatt aattttttaa atgagtgctt taacttaaaa caggcgtttg gaatagctgc   2520

tgcaatgtag tcttgtgtgt gatttttttt taagttgatg tgcagtctaa ttgttgtttc   2580

ataaaagttg gatctgttcc tatgcccagg atgattttgt gaaccgtgaa gtacgtgaga   2640

ctagaagacg cccaaacaag tcagataata gtaactacaa tggttgctga tgttgagatt   2700

attgttgaac tataattaat aatttggatg gcagaattta tctctttttt gtaaactctc   2760

ataactgaat tgcttaagta taatttatag aatttcagtg cagttcattc ttaatggaaa   2820

atctgaaacc taaattgcag atttaaaagg tactgtacaa ccattatatc tgtaaataac   2880

ttagcacctt tttgtcactt agaataatat gtactactac ttgagtgagc gcttttggaa   2940

gttatatcaa gttctagtgt ttgcttctta gtaactgaac tgaatttaca gttctgtcct   3000

agacattttg cactaaagta gccgaatcca ctctcatgtc ttttcgttaa tgtgctctgt   3060

accactggtg agtgctccat agtttcctta cctgctgcta cagaatgtta ttttacatcc   3120

ctatggctat tgccaaggct acaaaaaagg aaagctatat ttgtatgcaa cactaacctt   3180

ttgactgcta atgtatgttt ctgcttgctg tgccttgtta tggctgcttt ttttgtgcta   3240

ataaagtatg tttggtgttc tccttgtata tctgctgttt tatacatttg caacaatttc   3300

tcttgtaaat ggaatggttt ggggttttta aataagcatt aactaacaac ctttctatag   3360

ttaatgcaga gttaatgaac agtctaatat tgacttatca gaataagcta actctaaatt   3420

taatgctcta catcttatca gtcataatta tatatactgt ggaacagtat ctgtagttac   3480

tgcaaattac tgtacagttt aggttataac agaaaactga cagagaagta ataaacctat   3540

tgatttctct gcttataaat gaaagattga aactatccaa tgacatatta tagtaaatga   3600

gtatctgtaa cctcccactg catcagaagc aggttaaatg aagtcttgtg aatttgtaat   3660

agatcagtac catttattgg tttggggacc atcttaatta aaaataaatg cccaaaatgt   3720

agaactttaa ccaaagactt gtccctttta aagcaaaatg gggattgaag ggacttataa   3780

tttctgttgt ttctaattaa agtccctgaa gatcatatac caaagtgttt gagaacttca   3840

tccaaaccta ctttaaagca ttatgtgcaa ttaagttgtt atgacataat tatattgcct   3900

aattgttggg tcttttttct tgagcttata atgtacctgg aaaataaacc tcttgag      3957


<210>  1433
<211>  56
<212>  PRT
<213>  Homo sapiens

<400>  1433


Met Ala Ala Ala Gln Ser Ala His Pro Ser Gly Arg Thr Ser Pro Thr 
1               5                   10                  15      


Pro Gly Pro Pro Pro Ser Arg Ala Leu Pro Pro Ser Phe Gly Leu His 
            20                  25                  30          


Leu Pro Ala Ser Gly Leu Ala Ala Arg Asn Pro Ala Pro Leu Lys Pro 
        35                  40                  45              


Cys Leu Leu Leu Val Thr Ile Leu 
    50                  55      

<210>  1434
<211>  4319
<212>  DNA
<213>  Homo sapiens

<400>  1434
agactccaaa atggcagccg cgcagagcgc gcacccaagc ggccggacct ccccgactcc     60

cgggccgccc ccgtctcgcg ccctgcctcc ctccttcggc cttcacctac ccgcctccgg    120

attggccgct aggaatcccg cccctctaaa gccctgcctg ctattggtca cgattttata    180

atcaatggat aaagtgggaa aaatgtggaa taacttcaaa tacaggtgtc agaatctctt    240

cggtcatgag ggaggaagcc gtagtgaaaa tgtggacatg aactccaaca gatgtttgtc    300

tgtcaaagag aaaaacatca gcataggaga ctcaactcct cagcaacaaa gcagtccctt    360

aagagaaaat attgccttac aactgggatt aagcccttcg aagaattctt caaggagaaa    420

tcaaaattgt gccacagaaa tccctcaaat tgttgaaata agcatcgaaa aggataatga    480

ttcttgtgtt accccaggaa caagacttgc acgaagagat tcctactctc gacatgctcc    540

atggggtggg aagaaaaaac attcctgttc tacaaagacc cagagttcat tggatgctga    600

taaaaagttt ggtagaactc gaagtggact tcaaaggaga gagaggcgct acggcgtaag    660

ttctgtacac gacatggaca gtgtttccag cagaactgta ggaagtcgct ctctaagaca    720

gaggttgcag gatactgtgg gcttgtgttt tcccatgaga acttacagca agcagtcaaa    780

gcctctcttt tccaataaaa gaaaaatcca tctctctgaa ttaatgcttg agaaatgccc    840

ttttcctgct ggctcagatt tagcccaaaa atggcatttg attaaacagc atacagctcc    900

tgtgagccca cattcaacat tttttgatac atttgatcca tctttggttt ctacagaaga    960

tgaagaagat aggcttagag agagaaggcg gcttagtatt gaagaagggg ttgatccccc   1020

tcccaatgca caaatacata catttgaagc tactgcacag gttaatccat tatataaact   1080

gggaccaaaa ttagctcctg gaatgactga aataagtggg gacagttctg caattccaca   1140

agctaattgt gactcggaag aggatacaac caccctgtgt ttgcagtcac ggaggcagaa   1200

gcagcgtcag atatctggag acagccatac ccatgttagc agacagggag cttggaaagt   1260

ccacacacag attgattaca tacactgcct cgtgcctgat ttgcttcaaa ttacagggaa   1320

tccctgttac tggggagtga tggaccgtta tgaagcagaa gcccttctcg aagggaaacc   1380

tgaaggcacg tttttgctca gggactctgc gcaagaggac tacctcttct ctgtgagctt   1440

ccgccgctac aacagatccc tgcatgcccg aattgagcag tggaatcaca actttagttt   1500

cgacgcccat gacccgtgtg tatttcactc ctccactgta acgggacttt tagaacatta   1560

taaagatccc agttcgtgca tgttttttga accattgctt actatatcac taaataggac   1620

tttccctttt agcctgcagt atatctgtcg cgcggtaatc tgcaggtgca ctacgtatga   1680

tggaattgat gggctccctc taccctcaat gttacaggat tttttaaaag agtatcatta   1740

taaacaaaaa gttagagttc gctggttgga acgagaacca gtcaaggcaa agtaaactct   1800

ccggtcccca aaggttgtta actaggtccg ctttcatgtg catcagacag tacacctata   1860

gcaagcacac gtagcagtgt taggcttttt catacagtat gtaagcttag tgttagtatc   1920

tgtcagatgc tacctgctgt tacttattca gataaacatg gtgcctattg gaacaatagc   1980

ggatagagct acaggtgttc agtaagacta caaaaacatt ttgcctattt cgctaacagt   2040

ttggttttta atggctgtgg tatttgagtg aggcaactct ggggcatttg ttatgaagaa   2100

ttctatttct tactgaagaa caaattatta atattggatg agtatttcaa cagtgtgact   2160

aatgtttgaa attatttttt ctaagagttt ttctataacc ttccaaaagt cgtgatgttt   2220

gtagttacta taaatcaagc tttggaagtc caaaaagaat aaaagactgc cttcctttta   2280

gaaaaaaatg caattttctg gccacaaggg catagtgcag ttcacttacg tgttgatgta   2340

gtttataatc agacgccttt tctcttctgc aaaaggtact gttaagtaaa ccagattttc   2400

taaataggca ttcttaaaat ttcagactta caaagctagt agtagaattt tattgaaagg   2460

cctaggtatt aattttttaa atgagtgctt taacttaaaa caggcgtttg gaatagctgc   2520

tgcaatgtag tcttgtgtgt gatttttttt taagttgatg tgcagtctaa ttgttgtttc   2580

ataaaagttg gatctgttcc tatgcccagg atgattttgt gaaccgtgaa gtacgtgaga   2640

ctagaagacg cccaaacaag tcagataata gtaactacaa tggttgctga tgttgagatt   2700

attgttgaac tataattaat aatttggatg gcagaattta tctctttttt gtaaactctc   2760

ataactgaat tgcttaagta taatttatag aatttcagtg cagttcattc ttaatggaaa   2820

atctgaaacc taaattgcag atttaaaagg tactgtacaa ccattatatc tgtaaataac   2880

ttagcacctt tttgtcactt agaataatat gtactactac ttgagtgagc gcttttggaa   2940

gttatatcaa gttctagtgt ttgcttctta gtaactgaac tgaatttaca gttctgtcct   3000

agacattttg cactaaagta gccgaatcca ctctcatgtc ttttcgttaa tgtgctctgt   3060

accactggtg agtgctccat agtttcctta cctgctgcta cagaatgtta ttttacatcc   3120

ctatggctat tgccaaggct acaaaaaagg aaagctatat ttgtatgcaa cactaacctt   3180

ttgactgcta atgtatgttt ctgcttgctg tgccttgtta tggctgcttt ttttgtgcta   3240

ataaagtatg tttggtgttc tccttgtata tctgctgttt tatacatttg caacaatttc   3300

tcttgtaaat ggaatggttt ggggttttta aataagcatt aactaacaac ctttctatag   3360

ttaatgcaga gttaatgaac agtctaatat tgacttatca gaataagcta actctaaatt   3420

taatgctcta catcttatca gtcataatta tatatactgt ggaacagtat ctgtagttac   3480

tgcaaattac tgtacagttt aggttataac agaaaactga cagagaagta ataaacctat   3540

tgatttctct gcttataaat gaaagattga aactatccaa tgacatatta tagtaaatga   3600

gtatctgtaa cctcccactg catcagaagc aggttaaatg aagtcttgtg aatttgtaat   3660

agatcagtac catttattgg tttggggacc atcttaatta aaaataaatg cccaaaatgt   3720

agaactttaa ccaaagactt gtccctttta aagcaaaatg gggattgaag ggacttataa   3780

tttctgttgt ttctaattaa agtccctgaa gatcatatac caaagtgttt gagaacttca   3840

tccaaaccta ctttaaagca ttatgtgcaa ttaagttgtt atgacataat tatattgcct   3900

aattgttggg tcttttttct tgagcttata atgtacctgg aaaataaacc tcttgagaaa   3960

aagaaaagtt catactgatt attggaaaag gactatatat gtgagcaaga ttgtgtttta   4020

gagaggaaac ttgaaactcc aagaaagcac ttgatgtttt tatatgcttg tagcaaattg   4080

atgttctaac tgtagtttta tagaaagtat taatgctttt atgtatttca aaactttcat   4140

atgttaaatg gaaattgttt taaatgtgtt tgagtttatg taagcatgta tacactgtgc   4200

taaaagtcac atgtttcagt ttgtgtataa tattaatatg caatttttgg tttaaatttt   4260

tgtcttaaaa tattagtggc ttacatttta aaaaagaaaa atcaccagca tgaacttgc    4319


<210>  1435
<211>  56
<212>  PRT
<213>  Homo sapiens

<400>  1435


Met Ala Ala Ala Gln Ser Ala His Pro Ser Gly Arg Thr Ser Pro Thr 
1               5                   10                  15      


Pro Gly Pro Pro Pro Ser Arg Ala Leu Pro Pro Ser Phe Gly Leu His 
            20                  25                  30          


Leu Pro Ala Ser Gly Leu Ala Ala Arg Asn Pro Ala Pro Leu Lys Pro 
        35                  40                  45              


Cys Leu Leu Leu Val Thr Ile Leu 
    50                  55      

<210>  1436
<211>  5226
<212>  DNA
<213>  Homo sapiens

<400>  1436
agactccaaa atggcagccg cgcagagcgc gcacccaagc ggccggacct ccccgactcc     60

cgggccgccc ccgtctcgcg ccctgcctcc ctccttcggc cttcacctac ccgcctccgg    120

attggccgct aggaatcccg cccctctaaa gccctgcctg ctattggtca cgattttata    180

atcaatggat aaagtgggaa aaatgtggaa taacttcaaa tacaggtgtc agaatctctt    240

cggtcatgag ggaggaagcc gtagtgaaaa tgtggacatg aactccaaca gatgtttgtc    300

tgtcaaagag aaaaacatca gcataggaga ctcaactcct cagcaacaaa gcagtccctt    360

aagagaaaat attgccttac aactgggatt aagcccttcg aagaattctt caaggagaaa    420

tcaaaattgt gccacagaaa tccctcaaat tgttgaaata agcatcgaaa aggataatga    480

ttcttgtgtt accccaggaa caagacttgc acgaagagat tcctactctc gacatgctcc    540

atggggtggg aagaaaaaac attcctgttc tacaaagacc cagagttcat tggatgctga    600

taaaaagttt ggtagaactc gaagtggact tcaaaggaga gagaggcgct acggcgtaag    660

ttctgtacac gacatggaca gtgtttccag cagaactgta ggaagtcgct ctctaagaca    720

gaggttgcag gatactgtgg gcttgtgttt tcccatgaga acttacagca agcagtcaaa    780

gcctctcttt tccaataaaa gaaaaatcca tctctctgaa ttaatgcttg agaaatgccc    840

ttttcctgct ggctcagatt tagcccaaaa atggcatttg attaaacagc atacagctcc    900

tgtgagccca cattcaacat tttttgatac atttgatcca tctttggttt ctacagaaga    960

tgaagaagat aggcttagag agagaaggcg gcttagtatt gaagaagggg ttgatccccc   1020

tcccaatgca caaatacata catttgaagc tactgcacag gttaatccat tatataaact   1080

gggaccaaaa ttagctcctg gaatgactga aataagtggg gacagttctg caattccaca   1140

agctaattgt gactcggaag aggatacaac caccctgtgt ttgcagtcac ggaggcagaa   1200

gcagcgtcag atatctggag acagccatac ccatgttagc agacagggag cttggaaagt   1260

ccacacacag attgattaca tacactgcct cgtgcctgat ttgcttcaaa ttacagggaa   1320

tccctgttac tggggagtga tggaccgtta tgaagcagaa gcccttctcg aagggaaacc   1380

tgaaggcacg tttttgctca gggactctgc gcaagaggac tacctcttct ctgtgagctt   1440

ccgccgctac aacagatccc tgcatgcccg aattgagcag tggaatcaca actttagttt   1500

cgacgcccat gacccgtgtg tatttcactc ctccactgta acgggacttt tagaacatta   1560

taaagatccc agttcgtgca tgttttttga accattgctt actatatcac taaataggac   1620

tttccctttt agcctgcagt atatctgtcg cgcggtaatc tgcaggtgca ctacgtatga   1680

tggaattgat gggctccctc taccctcaat gttacaggat tttttaaaag agtatcatta   1740

taaacaaaaa gttagagttc gctggttgga acgagaacca gtcaaggcaa agtaaactct   1800

ccggtcccca aaggttgtta actaggtccg ctttcatgtg catcagacag tacacctata   1860

gcaagcacac gtagcagtgt taggcttttt catacagtat gtaagcttag tgttagtatc   1920

tgtcagatgc tacctgctgt tacttattca gataaacatg gtgcctattg gaacaatagc   1980

ggatagagct acaggtgttc agtaagacta caaaaacatt ttgcctattt cgctaacagt   2040

ttggttttta atggctgtgg tatttgagtg aggcaactct ggggcatttg ttatgaagaa   2100

ttctatttct tactgaagaa caaattatta atattggatg agtatttcaa cagtgtgact   2160

aatgtttgaa attatttttt ctaagagttt ttctataacc ttccaaaagt cgtgatgttt   2220

gtagttacta taaatcaagc tttggaagtc caaaaagaat aaaagactgc cttcctttta   2280

gaaaaaaatg caattttctg gccacaaggg catagtgcag ttcacttacg tgttgatgta   2340

gtttataatc agacgccttt tctcttctgc aaaaggtact gttaagtaaa ccagattttc   2400

taaataggca ttcttaaaat ttcagactta caaagctagt agtagaattt tattgaaagg   2460

cctaggtatt aattttttaa atgagtgctt taacttaaaa caggcgtttg gaatagctgc   2520

tgcaatgtag tcttgtgtgt gatttttttt taagttgatg tgcagtctaa ttgttgtttc   2580

ataaaagttg gatctgttcc tatgcccagg atgattttgt gaaccgtgaa gtacgtgaga   2640

ctagaagacg cccaaacaag tcagataata gtaactacaa tggttgctga tgttgagatt   2700

attgttgaac tataattaat aatttggatg gcagaattta tctctttttt gtaaactctc   2760

ataactgaat tgcttaagta taatttatag aatttcagtg cagttcattc ttaatggaaa   2820

atctgaaacc taaattgcag atttaaaagg tactgtacaa ccattatatc tgtaaataac   2880

ttagcacctt tttgtcactt agaataatat gtactactac ttgagtgagc gcttttggaa   2940

gttatatcaa gttctagtgt ttgcttctta gtaactgaac tgaatttaca gttctgtcct   3000

agacattttg cactaaagta gccgaatcca ctctcatgtc ttttcgttaa tgtgctctgt   3060

accactggtg agtgctccat agtttcctta cctgctgcta cagaatgtta ttttacatcc   3120

ctatggctat tgccaaggct acaaaaaagg aaagctatat ttgtatgcaa cactaacctt   3180

ttgactgcta atgtatgttt ctgcttgctg tgccttgtta tggctgcttt ttttgtgcta   3240

ataaagtatg tttggtgttc tccttgtata tctgctgttt tatacatttg caacaatttc   3300

tcttgtaaat ggaatggttt ggggttttta aataagcatt aactaacaac ctttctatag   3360

ttaatgcaga gttaatgaac agtctaatat tgacttatca gaataagcta actctaaatt   3420

taatgctcta catcttatca gtcataatta tatatactgt ggaacagtat ctgtagttac   3480

tgcaaattac tgtacagttt aggttataac agaaaactga cagagaagta ataaacctat   3540

tgatttctct gcttataaat gaaagattga aactatccaa tgacatatta tagtaaatga   3600

gtatctgtaa cctcccactg catcagaagc aggttaaatg aagtcttgtg aatttgtaat   3660

agatcagtac catttattgg tttggggacc atcttaatta aaaataaatg cccaaaatgt   3720

agaactttaa ccaaagactt gtccctttta aagcaaaatg gggattgaag ggacttataa   3780

tttctgttgt ttctaattaa agtccctgaa gatcatatac caaagtgttt gagaacttca   3840

tccaaaccta ctttaaagca ttatgtgcaa ttaagttgtt atgacataat tatattgcct   3900

aattgttggg tcttttttct tgagcttata atgtacctgg aaaataaacc tcttgagaaa   3960

aagaaaagtt catactgatt attggaaaag gactatatat gtgagcaaga ttgtgtttta   4020

gagaggaaac ttgaaactcc aagaaagcac ttgatgtttt tatatgcttg tagcaaattg   4080

atgttctaac tgtagtttta tagaaagtat taatgctttt atgtatttca aaactttcat   4140

atgttaaatg gaaattgttt taaatgtgtt tgagtttatg taagcatgta tacactgtgc   4200

taaaagtcac atgtttcagt ttgtgtataa tattaatatg caatttttgg tttaaatttt   4260

tgtcttaaaa tattagtggc ttacatttta aaaaagaaaa atcaccagca tgaacttgca   4320

cctaagtcta tattcactgt gtccttttct gaatcccatt gtagcctgtc aactaaattt   4380

gagtgttaac ggtcttttta aagtgcattt aaatacaaac caggaatttc tttagaagtt   4440

gagatacatc tttatagttg aaataattaa cccaagaaaa ggttgctttg atttgtaccc   4500

attctcattc attttcttca ttcccttaca cacacacaca cacctctccc ttccgcatac   4560

atataagtgt gtattatata tttatgtatg cacatatata catttatgtt gttaatatta   4620

ctttagatgg catttccacc tgatacaaaa acatttagag atcttattct atagatatta   4680

cctaaagagt attcttgtac tattcgaatt ttattatctg cactaaaagt ttagccttgc   4740

tactttagcc ttgtttataa tacagtcacc ttacaaagag aaagagttca tctgtatttt   4800

gttttctggc taaacacagt acaaaatatt tgaagaaaaa cagcttggat taaatagtta   4860

ctaagagtta taattaaatt tatgtttctt agacaaaact tgagcccaaa taatcattct   4920

ccacacacca ggctgttttt agctcttatg tttacgtaag atttataatg gctagaaccg   4980

taagaactga tacttgaatt ttaagcttca tttgacaaaa tcgaaagctt aagaattttt   5040

ttatttcaca ttttgatctg gttgctattt atgtttattt caaagcttgc ttttctctct   5100

ggcactgaac actaatttgg tgagttttat tgagactggt cttagatctc ttatttttat   5160

agcaaatact gctttttggt agagccaaag agcctgtgag tgaatcagga ccctcctttt   5220

tttttg                                                              5226


<210>  1437
<211>  56
<212>  PRT
<213>  Homo sapiens

<400>  1437


Met Ala Ala Ala Gln Ser Ala His Pro Ser Gly Arg Thr Ser Pro Thr 
1               5                   10                  15      


Pro Gly Pro Pro Pro Ser Arg Ala Leu Pro Pro Ser Phe Gly Leu His 
            20                  25                  30          


Leu Pro Ala Ser Gly Leu Ala Ala Arg Asn Pro Ala Pro Leu Lys Pro 
        35                  40                  45              


Cys Leu Leu Leu Val Thr Ile Leu 
    50                  55      

<210>  1438
<211>  3366
<212>  DNA
<213>  Homo sapiens

<400>  1438
attctggtgg gggttggggg gaggggggag gggaaacggg tgaagaaggg gaggcggcag     60

ggaagggggt gggggcctgg cgggggcatc cggcggagct ggggtccccg ggctccgtcc    120

ggaggaagcg acgctgcgct cgctgggcag tcggagggga cgggacgcac cggagggcag    180

gcggactcgc cctgtcggtg actgcgccgt ccgggcccgt cctgcctggc cgcaggtgcc    240

ctggatgagg ccgccccgcg cgccccaaac gattttataa tcaatggata aagtgggaaa    300

aatgtggaat aacttcaaat acaggtgtca gaatctcttc ggtcatgagg gaggaagccg    360

tagtgaaaat gtggacatga actccaacag atgtttgtct gtcaaagaga aaaacatcag    420

cataggagac tcaactcctc agcaacaaag cagtccctta agagaaaata ttgccttaca    480

actgggatta agcccttcga agaattcttc aaggagaaat caaaattgtg ccacagaaat    540

ccctcaaatt gttgaaataa gcatcgaaaa ggataatgat tcttgtgtta ccccaggaac    600

aagacttgca cgaagagatt cctactctcg acatgctcca tggggtggga agaaaaaaca    660

ttcctgttct acaaagaccc agagttcatt ggatgctgat aaaaagtttg gtagaactcg    720

aagtggactt caaaggagag agaggcgcta cggcgtaagt tctgtacacg acatggacag    780

tgtttccagc agaactgtag gaagtcgctc tctaagacag aggttgcagg atactgtggg    840

cttgtgtttt cccatgagaa cttacagcaa gcagtcaaag cctctctttt ccaataaaag    900

aaaaatccat ctctctgaat taatgcttga gaaatgccct tttcctgctg gctcagattt    960

agcccaaaaa tggcatttga ttaaacagca tacagctcct gtgagcccac attcaacatt   1020

ttttgataca tttgatccat ctttggtttc tacagaagat gaagaagata ggcttagaga   1080

gagaaggcgg cttagtattg aagaaggggt tgatccccct cccaatgcac aaatacatac   1140

atttgaagct actgcacagg ttaatccatt atataaactg ggaccaaaat tagctcctgg   1200

aatgactgaa ataagtgggg acagttctgc aattccacaa gctaattgtg actcggaaga   1260

ggatacaacc accctgtgtt tgcagtcacg gaggcagaag cagcgtcaga tatctggaga   1320

cagccatacc catgttagca gacagggagc ttggaaagtc cacacacaga ttgattacat   1380

acactgcctc gtgcctgatt tgcttcaaat tacagggaat ccctgttact ggggagtgat   1440

ggaccgttat gaagcagaag cccttctcga agggaaacct gaaggcacgt ttttgctcag   1500

ggactctgcg caagaggact acctcttctc tgtgagcttc cgccgctaca acagatccct   1560

gcatgcccga attgagcagt ggaatcacaa ctttagtttc gacgcccatg acccgtgtgt   1620

atttcactcc tccactgtaa cgggactttt agaacattat aaagatccca gttcgtgcat   1680

gttttttgaa ccattgctta ctatatcact aaataggact ttccctttta gcctgcagta   1740

tatctgtcgc gcggtaatct gcaggtgcac tacgtatgat ggaattgatg ggctccctct   1800

accctcaatg ttacaggatt ttttaaaaga gtatcattat aaacaaaaag ttagagttcg   1860

ctggttggaa cgagaaccag tcaaggcaaa gtaaactctc cggtccccaa aggttgttaa   1920

ctaggtccgc tttcatgtgc atcagacagt acacctatag caagcacacg tagcagtgtt   1980

aggctttttc atacagtatg taagcttagt gttagtatct gtcagatgct acctgctgtt   2040

acttattcag ataaacatgg tgcctattgg aacaatagcg gatagagcta caggtgttca   2100

gtaagactac aaaaacattt tgcctatttc gctaacagtt tggtttttaa tggctgtggt   2160

atttgagtga ggcaactctg gggcatttgt tatgaagaat tctatttctt actgaagaac   2220

aaattattaa tattggatga gtatttcaac agtgtgacta atgtttgaaa ttattttttc   2280

taagagtttt tctataacct tccaaaagtc gtgatgtttg tagttactat aaatcaagct   2340

ttggaagtcc aaaaagaata aaagactgcc ttccttttag aaaaaaatgc aattttctgg   2400

ccacaagggc atagtgcagt tcacttacgt gttgatgtag tttataatca gacgcctttt   2460

ctcttctgca aaaggtactg ttaagtaaac cagattttct aaataggcat tcttaaaatt   2520

tcagacttac aaagctagta gtagaatttt attgaaaggc ctaggtatta attttttaaa   2580

tgagtgcttt aacttaaaac aggcgtttgg aatagctgct gcaatgtagt cttgtgtgtg   2640

attttttttt aagttgatgt gcagtctaat tgttgtttca taaaagttgg atctgttcct   2700

atgcccagga tgattttgtg aaccgtgaag tacgtgagac tagaagacgc ccaaacaagt   2760

cagataatag taactacaat ggttgctgat gttgagatta ttgttgaact ataattaata   2820

atttggatgg cagaatttat ctcttttttg taaactctca taactgaatt gcttaagtat   2880

aatttataga atttcagtgc agttcattct taatggaaaa tctgaaacct aaattgcaga   2940

tttaaaaggt actgtacaac cattatatct gtaaataact tagcaccttt ttgtcactta   3000

gaataatatg tactactact tgagtgagcg cttttggaag ttatatcaag ttctagtgtt   3060

tgcttcttag taactgaact gaatttacag ttctgtccta gacattttgc actaaagtag   3120

ccgaatccac tctcatgtct tttcgttaat gtgctctgta ccactggtga gtgctccata   3180

gtttccttac ctgctgctac agaatgttat tttacatccc tatggctatt gccaaggcta   3240

caaaaaagga aagctatatt tgtatgcaac actaaccttt tgactgctaa tgtatgtttc   3300

tgcttgctgt gccttgttat ggctgctttt tttgtgctaa taaagtatgt ttggtgttct   3360

ccttgt                                                              3366


<210>  1439
<211>  536
<212>  PRT
<213>  Homo sapiens

<400>  1439


Met Asp Lys Val Gly Lys Met Trp Asn Asn Phe Lys Tyr Arg Cys Gln 
1               5                   10                  15      


Asn Leu Phe Gly His Glu Gly Gly Ser Arg Ser Glu Asn Val Asp Met 
            20                  25                  30          


Asn Ser Asn Arg Cys Leu Ser Val Lys Glu Lys Asn Ile Ser Ile Gly 
        35                  40                  45              


Asp Ser Thr Pro Gln Gln Gln Ser Ser Pro Leu Arg Glu Asn Ile Ala 
    50                  55                  60                  


Leu Gln Leu Gly Leu Ser Pro Ser Lys Asn Ser Ser Arg Arg Asn Gln 
65                  70                  75                  80  


Asn Cys Ala Thr Glu Ile Pro Gln Ile Val Glu Ile Ser Ile Glu Lys 
                85                  90                  95      


Asp Asn Asp Ser Cys Val Thr Pro Gly Thr Arg Leu Ala Arg Arg Asp 
            100                 105                 110         


Ser Tyr Ser Arg His Ala Pro Trp Gly Gly Lys Lys Lys His Ser Cys 
        115                 120                 125             


Ser Thr Lys Thr Gln Ser Ser Leu Asp Ala Asp Lys Lys Phe Gly Arg 
    130                 135                 140                 


Thr Arg Ser Gly Leu Gln Arg Arg Glu Arg Arg Tyr Gly Val Ser Ser 
145                 150                 155                 160 


Val His Asp Met Asp Ser Val Ser Ser Arg Thr Val Gly Ser Arg Ser 
                165                 170                 175     


Leu Arg Gln Arg Leu Gln Asp Thr Val Gly Leu Cys Phe Pro Met Arg 
            180                 185                 190         


Thr Tyr Ser Lys Gln Ser Lys Pro Leu Phe Ser Asn Lys Arg Lys Ile 
        195                 200                 205             


His Leu Ser Glu Leu Met Leu Glu Lys Cys Pro Phe Pro Ala Gly Ser 
    210                 215                 220                 


Asp Leu Ala Gln Lys Trp His Leu Ile Lys Gln His Thr Ala Pro Val 
225                 230                 235                 240 


Ser Pro His Ser Thr Phe Phe Asp Thr Phe Asp Pro Ser Leu Val Ser 
                245                 250                 255     


Thr Glu Asp Glu Glu Asp Arg Leu Arg Glu Arg Arg Arg Leu Ser Ile 
            260                 265                 270         


Glu Glu Gly Val Asp Pro Pro Pro Asn Ala Gln Ile His Thr Phe Glu 
        275                 280                 285             


Ala Thr Ala Gln Val Asn Pro Leu Tyr Lys Leu Gly Pro Lys Leu Ala 
    290                 295                 300                 


Pro Gly Met Thr Glu Ile Ser Gly Asp Ser Ser Ala Ile Pro Gln Ala 
305                 310                 315                 320 


Asn Cys Asp Ser Glu Glu Asp Thr Thr Thr Leu Cys Leu Gln Ser Arg 
                325                 330                 335     


Arg Gln Lys Gln Arg Gln Ile Ser Gly Asp Ser His Thr His Val Ser 
            340                 345                 350         


Arg Gln Gly Ala Trp Lys Val His Thr Gln Ile Asp Tyr Ile His Cys 
        355                 360                 365             


Leu Val Pro Asp Leu Leu Gln Ile Thr Gly Asn Pro Cys Tyr Trp Gly 
    370                 375                 380                 


Val Met Asp Arg Tyr Glu Ala Glu Ala Leu Leu Glu Gly Lys Pro Glu 
385                 390                 395                 400 


Gly Thr Phe Leu Leu Arg Asp Ser Ala Gln Glu Asp Tyr Leu Phe Ser 
                405                 410                 415     


Val Ser Phe Arg Arg Tyr Asn Arg Ser Leu His Ala Arg Ile Glu Gln 
            420                 425                 430         


Trp Asn His Asn Phe Ser Phe Asp Ala His Asp Pro Cys Val Phe His 
        435                 440                 445             


Ser Ser Thr Val Thr Gly Leu Leu Glu His Tyr Lys Asp Pro Ser Ser 
    450                 455                 460                 


Cys Met Phe Phe Glu Pro Leu Leu Thr Ile Ser Leu Asn Arg Thr Phe 
465                 470                 475                 480 


Pro Phe Ser Leu Gln Tyr Ile Cys Arg Ala Val Ile Cys Arg Cys Thr 
                485                 490                 495     


Thr Tyr Asp Gly Ile Asp Gly Leu Pro Leu Pro Ser Met Leu Gln Asp 
            500                 505                 510         


Phe Leu Lys Glu Tyr His Tyr Lys Gln Lys Val Arg Val Arg Trp Leu 
        515                 520                 525             


Glu Arg Glu Pro Val Lys Ala Lys 
    530                 535     

<210>  1440
<211>  4056
<212>  DNA
<213>  Homo sapiens

<400>  1440
attctggtgg gggttggggg gaggggggag gggaaacggg tgaagaaggg gaggcggcag     60

ggaagggggt gggggcctgg cgggggcatc cggcggagct ggggtccccg ggctccgtcc    120

ggaggaagcg acgctgcgct cgctgggcag tcggagggga cgggacgcac cggagggcag    180

gcggactcgc cctgtcggtg actgcgccgt ccgggcccgt cctgcctggc cgcaggtgcc    240

ctggatgagg ccgccccgcg cgccccaaac gattttataa tcaatggata aagtgggaaa    300

aatgtggaat aacttcaaat acaggtgtca gaatctcttc ggtcatgagg gaggaagccg    360

tagtgaaaat gtggacatga actccaacag atgtttgtct gtcaaagaga aaaacatcag    420

cataggagac tcaactcctc agcaacaaag cagtccctta agagaaaata ttgccttaca    480

actgggatta agcccttcga agaattcttc aaggagaaat caaaattgtg ccacagaaat    540

ccctcaaatt gttgaaataa gcatcgaaaa ggataatgat tcttgtgtta ccccaggaac    600

aagacttgca cgaagagatt cctactctcg acatgctcca tggggtggga agaaaaaaca    660

ttcctgttct acaaagaccc agagttcatt ggatgctgat aaaaagtttg gtagaactcg    720

aagtggactt caaaggagag agaggcgcta cggcgtaagt tctgtacacg acatggacag    780

tgtttccagc agaactgtag gaagtcgctc tctaagacag aggttgcagg atactgtggg    840

cttgtgtttt cccatgagaa cttacagcaa gcagtcaaag cctctctttt ccaataaaag    900

aaaaatccat ctctctgaat taatgcttga gaaatgccct tttcctgctg gctcagattt    960

agcccaaaaa tggcatttga ttaaacagca tacagctcct gtgagcccac attcaacatt   1020

ttttgataca tttgatccat ctttggtttc tacagaagat gaagaagata ggcttagaga   1080

gagaaggcgg cttagtattg aagaaggggt tgatccccct cccaatgcac aaatacatac   1140

atttgaagct actgcacagg ttaatccatt atataaactg ggaccaaaat tagctcctgg   1200

aatgactgaa ataagtgggg acagttctgc aattccacaa gctaattgtg actcggaaga   1260

ggatacaacc accctgtgtt tgcagtcacg gaggcagaag cagcgtcaga tatctggaga   1320

cagccatacc catgttagca gacagggagc ttggaaagtc cacacacaga ttgattacat   1380

acactgcctc gtgcctgatt tgcttcaaat tacagggaat ccctgttact ggggagtgat   1440

ggaccgttat gaagcagaag cccttctcga agggaaacct gaaggcacgt ttttgctcag   1500

ggactctgcg caagaggact acctcttctc tgtgagcttc cgccgctaca acagatccct   1560

gcatgcccga attgagcagt ggaatcacaa ctttagtttc gacgcccatg acccgtgtgt   1620

atttcactcc tccactgtaa cgggactttt agaacattat aaagatccca gttcgtgcat   1680

gttttttgaa ccattgctta ctatatcact aaataggact ttccctttta gcctgcagta   1740

tatctgtcgc gcggtaatct gcaggtgcac tacgtatgat ggaattgatg ggctccctct   1800

accctcaatg ttacaggatt ttttaaaaga gtatcattat aaacaaaaag ttagagttcg   1860

ctggttggaa cgagaaccag tcaaggcaaa gtaaactctc cggtccccaa aggttgttaa   1920

ctaggtccgc tttcatgtgc atcagacagt acacctatag caagcacacg tagcagtgtt   1980

aggctttttc atacagtatg taagcttagt gttagtatct gtcagatgct acctgctgtt   2040

acttattcag ataaacatgg tgcctattgg aacaatagcg gatagagcta caggtgttca   2100

gtaagactac aaaaacattt tgcctatttc gctaacagtt tggtttttaa tggctgtggt   2160

atttgagtga ggcaactctg gggcatttgt tatgaagaat tctatttctt actgaagaac   2220

aaattattaa tattggatga gtatttcaac agtgtgacta atgtttgaaa ttattttttc   2280

taagagtttt tctataacct tccaaaagtc gtgatgtttg tagttactat aaatcaagct   2340

ttggaagtcc aaaaagaata aaagactgcc ttccttttag aaaaaaatgc aattttctgg   2400

ccacaagggc atagtgcagt tcacttacgt gttgatgtag tttataatca gacgcctttt   2460

ctcttctgca aaaggtactg ttaagtaaac cagattttct aaataggcat tcttaaaatt   2520

tcagacttac aaagctagta gtagaatttt attgaaaggc ctaggtatta attttttaaa   2580

tgagtgcttt aacttaaaac aggcgtttgg aatagctgct gcaatgtagt cttgtgtgtg   2640

attttttttt aagttgatgt gcagtctaat tgttgtttca taaaagttgg atctgttcct   2700

atgcccagga tgattttgtg aaccgtgaag tacgtgagac tagaagacgc ccaaacaagt   2760

cagataatag taactacaat ggttgctgat gttgagatta ttgttgaact ataattaata   2820

atttggatgg cagaatttat ctcttttttg taaactctca taactgaatt gcttaagtat   2880

aatttataga atttcagtgc agttcattct taatggaaaa tctgaaacct aaattgcaga   2940

tttaaaaggt actgtacaac cattatatct gtaaataact tagcaccttt ttgtcactta   3000

gaataatatg tactactact tgagtgagcg cttttggaag ttatatcaag ttctagtgtt   3060

tgcttcttag taactgaact gaatttacag ttctgtccta gacattttgc actaaagtag   3120

ccgaatccac tctcatgtct tttcgttaat gtgctctgta ccactggtga gtgctccata   3180

gtttccttac ctgctgctac agaatgttat tttacatccc tatggctatt gccaaggcta   3240

caaaaaagga aagctatatt tgtatgcaac actaaccttt tgactgctaa tgtatgtttc   3300

tgcttgctgt gccttgttat ggctgctttt tttgtgctaa taaagtatgt ttggtgttct   3360

ccttgtatat ctgctgtttt atacatttgc aacaatttct cttgtaaatg gaatggtttg   3420

gggtttttaa ataagcatta actaacaacc tttctatagt taatgcagag ttaatgaaca   3480

gtctaatatt gacttatcag aataagctaa ctctaaattt aatgctctac atcttatcag   3540

tcataattat atatactgtg gaacagtatc tgtagttact gcaaattact gtacagttta   3600

ggttataaca gaaaactgac agagaagtaa taaacctatt gatttctctg cttataaatg   3660

aaagattgaa actatccaat gacatattat agtaaatgag tatctgtaac ctcccactgc   3720

atcagaagca ggttaaatga agtcttgtga atttgtaata gatcagtacc atttattggt   3780

ttggggacca tcttaattaa aaataaatgc ccaaaatgta gaactttaac caaagacttg   3840

tcccttttaa agcaaaatgg ggattgaagg gacttataat ttctgttgtt tctaattaaa   3900

gtccctgaag atcatatacc aaagtgtttg agaacttcat ccaaacctac tttaaagcat   3960

tatgtgcaat taagttgtta tgacataatt atattgccta attgttgggt cttttttctt   4020

gagcttataa tgtacctgga aaataaacct cttgag                             4056


<210>  1441
<211>  536
<212>  PRT
<213>  Homo sapiens

<400>  1441


Met Asp Lys Val Gly Lys Met Trp Asn Asn Phe Lys Tyr Arg Cys Gln 
1               5                   10                  15      


Asn Leu Phe Gly His Glu Gly Gly Ser Arg Ser Glu Asn Val Asp Met 
            20                  25                  30          


Asn Ser Asn Arg Cys Leu Ser Val Lys Glu Lys Asn Ile Ser Ile Gly 
        35                  40                  45              


Asp Ser Thr Pro Gln Gln Gln Ser Ser Pro Leu Arg Glu Asn Ile Ala 
    50                  55                  60                  


Leu Gln Leu Gly Leu Ser Pro Ser Lys Asn Ser Ser Arg Arg Asn Gln 
65                  70                  75                  80  


Asn Cys Ala Thr Glu Ile Pro Gln Ile Val Glu Ile Ser Ile Glu Lys 
                85                  90                  95      


Asp Asn Asp Ser Cys Val Thr Pro Gly Thr Arg Leu Ala Arg Arg Asp 
            100                 105                 110         


Ser Tyr Ser Arg His Ala Pro Trp Gly Gly Lys Lys Lys His Ser Cys 
        115                 120                 125             


Ser Thr Lys Thr Gln Ser Ser Leu Asp Ala Asp Lys Lys Phe Gly Arg 
    130                 135                 140                 


Thr Arg Ser Gly Leu Gln Arg Arg Glu Arg Arg Tyr Gly Val Ser Ser 
145                 150                 155                 160 


Val His Asp Met Asp Ser Val Ser Ser Arg Thr Val Gly Ser Arg Ser 
                165                 170                 175     


Leu Arg Gln Arg Leu Gln Asp Thr Val Gly Leu Cys Phe Pro Met Arg 
            180                 185                 190         


Thr Tyr Ser Lys Gln Ser Lys Pro Leu Phe Ser Asn Lys Arg Lys Ile 
        195                 200                 205             


His Leu Ser Glu Leu Met Leu Glu Lys Cys Pro Phe Pro Ala Gly Ser 
    210                 215                 220                 


Asp Leu Ala Gln Lys Trp His Leu Ile Lys Gln His Thr Ala Pro Val 
225                 230                 235                 240 


Ser Pro His Ser Thr Phe Phe Asp Thr Phe Asp Pro Ser Leu Val Ser 
                245                 250                 255     


Thr Glu Asp Glu Glu Asp Arg Leu Arg Glu Arg Arg Arg Leu Ser Ile 
            260                 265                 270         


Glu Glu Gly Val Asp Pro Pro Pro Asn Ala Gln Ile His Thr Phe Glu 
        275                 280                 285             


Ala Thr Ala Gln Val Asn Pro Leu Tyr Lys Leu Gly Pro Lys Leu Ala 
    290                 295                 300                 


Pro Gly Met Thr Glu Ile Ser Gly Asp Ser Ser Ala Ile Pro Gln Ala 
305                 310                 315                 320 


Asn Cys Asp Ser Glu Glu Asp Thr Thr Thr Leu Cys Leu Gln Ser Arg 
                325                 330                 335     


Arg Gln Lys Gln Arg Gln Ile Ser Gly Asp Ser His Thr His Val Ser 
            340                 345                 350         


Arg Gln Gly Ala Trp Lys Val His Thr Gln Ile Asp Tyr Ile His Cys 
        355                 360                 365             


Leu Val Pro Asp Leu Leu Gln Ile Thr Gly Asn Pro Cys Tyr Trp Gly 
    370                 375                 380                 


Val Met Asp Arg Tyr Glu Ala Glu Ala Leu Leu Glu Gly Lys Pro Glu 
385                 390                 395                 400 


Gly Thr Phe Leu Leu Arg Asp Ser Ala Gln Glu Asp Tyr Leu Phe Ser 
                405                 410                 415     


Val Ser Phe Arg Arg Tyr Asn Arg Ser Leu His Ala Arg Ile Glu Gln 
            420                 425                 430         


Trp Asn His Asn Phe Ser Phe Asp Ala His Asp Pro Cys Val Phe His 
        435                 440                 445             


Ser Ser Thr Val Thr Gly Leu Leu Glu His Tyr Lys Asp Pro Ser Ser 
    450                 455                 460                 


Cys Met Phe Phe Glu Pro Leu Leu Thr Ile Ser Leu Asn Arg Thr Phe 
465                 470                 475                 480 


Pro Phe Ser Leu Gln Tyr Ile Cys Arg Ala Val Ile Cys Arg Cys Thr 
                485                 490                 495     


Thr Tyr Asp Gly Ile Asp Gly Leu Pro Leu Pro Ser Met Leu Gln Asp 
            500                 505                 510         


Phe Leu Lys Glu Tyr His Tyr Lys Gln Lys Val Arg Val Arg Trp Leu 
        515                 520                 525             


Glu Arg Glu Pro Val Lys Ala Lys 
    530                 535     

<210>  1442
<211>  4418
<212>  DNA
<213>  Homo sapiens

<400>  1442
attctggtgg gggttggggg gaggggggag gggaaacggg tgaagaaggg gaggcggcag     60

ggaagggggt gggggcctgg cgggggcatc cggcggagct ggggtccccg ggctccgtcc    120

ggaggaagcg acgctgcgct cgctgggcag tcggagggga cgggacgcac cggagggcag    180

gcggactcgc cctgtcggtg actgcgccgt ccgggcccgt cctgcctggc cgcaggtgcc    240

ctggatgagg ccgccccgcg cgccccaaac gattttataa tcaatggata aagtgggaaa    300

aatgtggaat aacttcaaat acaggtgtca gaatctcttc ggtcatgagg gaggaagccg    360

tagtgaaaat gtggacatga actccaacag atgtttgtct gtcaaagaga aaaacatcag    420

cataggagac tcaactcctc agcaacaaag cagtccctta agagaaaata ttgccttaca    480

actgggatta agcccttcga agaattcttc aaggagaaat caaaattgtg ccacagaaat    540

ccctcaaatt gttgaaataa gcatcgaaaa ggataatgat tcttgtgtta ccccaggaac    600

aagacttgca cgaagagatt cctactctcg acatgctcca tggggtggga agaaaaaaca    660

ttcctgttct acaaagaccc agagttcatt ggatgctgat aaaaagtttg gtagaactcg    720

aagtggactt caaaggagag agaggcgcta cggcgtaagt tctgtacacg acatggacag    780

tgtttccagc agaactgtag gaagtcgctc tctaagacag aggttgcagg atactgtggg    840

cttgtgtttt cccatgagaa cttacagcaa gcagtcaaag cctctctttt ccaataaaag    900

aaaaatccat ctctctgaat taatgcttga gaaatgccct tttcctgctg gctcagattt    960

agcccaaaaa tggcatttga ttaaacagca tacagctcct gtgagcccac attcaacatt   1020

ttttgataca tttgatccat ctttggtttc tacagaagat gaagaagata ggcttagaga   1080

gagaaggcgg cttagtattg aagaaggggt tgatccccct cccaatgcac aaatacatac   1140

atttgaagct actgcacagg ttaatccatt atataaactg ggaccaaaat tagctcctgg   1200

aatgactgaa ataagtgggg acagttctgc aattccacaa gctaattgtg actcggaaga   1260

ggatacaacc accctgtgtt tgcagtcacg gaggcagaag cagcgtcaga tatctggaga   1320

cagccatacc catgttagca gacagggagc ttggaaagtc cacacacaga ttgattacat   1380

acactgcctc gtgcctgatt tgcttcaaat tacagggaat ccctgttact ggggagtgat   1440

ggaccgttat gaagcagaag cccttctcga agggaaacct gaaggcacgt ttttgctcag   1500

ggactctgcg caagaggact acctcttctc tgtgagcttc cgccgctaca acagatccct   1560

gcatgcccga attgagcagt ggaatcacaa ctttagtttc gacgcccatg acccgtgtgt   1620

atttcactcc tccactgtaa cgggactttt agaacattat aaagatccca gttcgtgcat   1680

gttttttgaa ccattgctta ctatatcact aaataggact ttccctttta gcctgcagta   1740

tatctgtcgc gcggtaatct gcaggtgcac tacgtatgat ggaattgatg ggctccctct   1800

accctcaatg ttacaggatt ttttaaaaga gtatcattat aaacaaaaag ttagagttcg   1860

ctggttggaa cgagaaccag tcaaggcaaa gtaaactctc cggtccccaa aggttgttaa   1920

ctaggtccgc tttcatgtgc atcagacagt acacctatag caagcacacg tagcagtgtt   1980

aggctttttc atacagtatg taagcttagt gttagtatct gtcagatgct acctgctgtt   2040

acttattcag ataaacatgg tgcctattgg aacaatagcg gatagagcta caggtgttca   2100

gtaagactac aaaaacattt tgcctatttc gctaacagtt tggtttttaa tggctgtggt   2160

atttgagtga ggcaactctg gggcatttgt tatgaagaat tctatttctt actgaagaac   2220

aaattattaa tattggatga gtatttcaac agtgtgacta atgtttgaaa ttattttttc   2280

taagagtttt tctataacct tccaaaagtc gtgatgtttg tagttactat aaatcaagct   2340

ttggaagtcc aaaaagaata aaagactgcc ttccttttag aaaaaaatgc aattttctgg   2400

ccacaagggc atagtgcagt tcacttacgt gttgatgtag tttataatca gacgcctttt   2460

ctcttctgca aaaggtactg ttaagtaaac cagattttct aaataggcat tcttaaaatt   2520

tcagacttac aaagctagta gtagaatttt attgaaaggc ctaggtatta attttttaaa   2580

tgagtgcttt aacttaaaac aggcgtttgg aatagctgct gcaatgtagt cttgtgtgtg   2640

attttttttt aagttgatgt gcagtctaat tgttgtttca taaaagttgg atctgttcct   2700

atgcccagga tgattttgtg aaccgtgaag tacgtgagac tagaagacgc ccaaacaagt   2760

cagataatag taactacaat ggttgctgat gttgagatta ttgttgaact ataattaata   2820

atttggatgg cagaatttat ctcttttttg taaactctca taactgaatt gcttaagtat   2880

aatttataga atttcagtgc agttcattct taatggaaaa tctgaaacct aaattgcaga   2940

tttaaaaggt actgtacaac cattatatct gtaaataact tagcaccttt ttgtcactta   3000

gaataatatg tactactact tgagtgagcg cttttggaag ttatatcaag ttctagtgtt   3060

tgcttcttag taactgaact gaatttacag ttctgtccta gacattttgc actaaagtag   3120

ccgaatccac tctcatgtct tttcgttaat gtgctctgta ccactggtga gtgctccata   3180

gtttccttac ctgctgctac agaatgttat tttacatccc tatggctatt gccaaggcta   3240

caaaaaagga aagctatatt tgtatgcaac actaaccttt tgactgctaa tgtatgtttc   3300

tgcttgctgt gccttgttat ggctgctttt tttgtgctaa taaagtatgt ttggtgttct   3360

ccttgtatat ctgctgtttt atacatttgc aacaatttct cttgtaaatg gaatggtttg   3420

gggtttttaa ataagcatta actaacaacc tttctatagt taatgcagag ttaatgaaca   3480

gtctaatatt gacttatcag aataagctaa ctctaaattt aatgctctac atcttatcag   3540

tcataattat atatactgtg gaacagtatc tgtagttact gcaaattact gtacagttta   3600

ggttataaca gaaaactgac agagaagtaa taaacctatt gatttctctg cttataaatg   3660

aaagattgaa actatccaat gacatattat agtaaatgag tatctgtaac ctcccactgc   3720

atcagaagca ggttaaatga agtcttgtga atttgtaata gatcagtacc atttattggt   3780

ttggggacca tcttaattaa aaataaatgc ccaaaatgta gaactttaac caaagacttg   3840

tcccttttaa agcaaaatgg ggattgaagg gacttataat ttctgttgtt tctaattaaa   3900

gtccctgaag atcatatacc aaagtgtttg agaacttcat ccaaacctac tttaaagcat   3960

tatgtgcaat taagttgtta tgacataatt atattgccta attgttgggt cttttttctt   4020

gagcttataa tgtacctgga aaataaacct cttgagaaaa agaaaagttc atactgatta   4080

ttggaaaagg actatatatg tgagcaagat tgtgttttag agaggaaact tgaaactcca   4140

agaaagcact tgatgttttt atatgcttgt agcaaattga tgttctaact gtagttttat   4200

agaaagtatt aatgctttta tgtatttcaa aactttcata tgttaaatgg aaattgtttt   4260

aaatgtgttt gagtttatgt aagcatgtat acactgtgct aaaagtcaca tgtttcagtt   4320

tgtgtataat attaatatgc aatttttggt ttaaattttt gtcttaaaat attagtggct   4380

tacattttaa aaaagaaaaa tcaccagcat gaacttgc                           4418


<210>  1443
<211>  536
<212>  PRT
<213>  Homo sapiens

<400>  1443


Met Asp Lys Val Gly Lys Met Trp Asn Asn Phe Lys Tyr Arg Cys Gln 
1               5                   10                  15      


Asn Leu Phe Gly His Glu Gly Gly Ser Arg Ser Glu Asn Val Asp Met 
            20                  25                  30          


Asn Ser Asn Arg Cys Leu Ser Val Lys Glu Lys Asn Ile Ser Ile Gly 
        35                  40                  45              


Asp Ser Thr Pro Gln Gln Gln Ser Ser Pro Leu Arg Glu Asn Ile Ala 
    50                  55                  60                  


Leu Gln Leu Gly Leu Ser Pro Ser Lys Asn Ser Ser Arg Arg Asn Gln 
65                  70                  75                  80  


Asn Cys Ala Thr Glu Ile Pro Gln Ile Val Glu Ile Ser Ile Glu Lys 
                85                  90                  95      


Asp Asn Asp Ser Cys Val Thr Pro Gly Thr Arg Leu Ala Arg Arg Asp 
            100                 105                 110         


Ser Tyr Ser Arg His Ala Pro Trp Gly Gly Lys Lys Lys His Ser Cys 
        115                 120                 125             


Ser Thr Lys Thr Gln Ser Ser Leu Asp Ala Asp Lys Lys Phe Gly Arg 
    130                 135                 140                 


Thr Arg Ser Gly Leu Gln Arg Arg Glu Arg Arg Tyr Gly Val Ser Ser 
145                 150                 155                 160 


Val His Asp Met Asp Ser Val Ser Ser Arg Thr Val Gly Ser Arg Ser 
                165                 170                 175     


Leu Arg Gln Arg Leu Gln Asp Thr Val Gly Leu Cys Phe Pro Met Arg 
            180                 185                 190         


Thr Tyr Ser Lys Gln Ser Lys Pro Leu Phe Ser Asn Lys Arg Lys Ile 
        195                 200                 205             


His Leu Ser Glu Leu Met Leu Glu Lys Cys Pro Phe Pro Ala Gly Ser 
    210                 215                 220                 


Asp Leu Ala Gln Lys Trp His Leu Ile Lys Gln His Thr Ala Pro Val 
225                 230                 235                 240 


Ser Pro His Ser Thr Phe Phe Asp Thr Phe Asp Pro Ser Leu Val Ser 
                245                 250                 255     


Thr Glu Asp Glu Glu Asp Arg Leu Arg Glu Arg Arg Arg Leu Ser Ile 
            260                 265                 270         


Glu Glu Gly Val Asp Pro Pro Pro Asn Ala Gln Ile His Thr Phe Glu 
        275                 280                 285             


Ala Thr Ala Gln Val Asn Pro Leu Tyr Lys Leu Gly Pro Lys Leu Ala 
    290                 295                 300                 


Pro Gly Met Thr Glu Ile Ser Gly Asp Ser Ser Ala Ile Pro Gln Ala 
305                 310                 315                 320 


Asn Cys Asp Ser Glu Glu Asp Thr Thr Thr Leu Cys Leu Gln Ser Arg 
                325                 330                 335     


Arg Gln Lys Gln Arg Gln Ile Ser Gly Asp Ser His Thr His Val Ser 
            340                 345                 350         


Arg Gln Gly Ala Trp Lys Val His Thr Gln Ile Asp Tyr Ile His Cys 
        355                 360                 365             


Leu Val Pro Asp Leu Leu Gln Ile Thr Gly Asn Pro Cys Tyr Trp Gly 
    370                 375                 380                 


Val Met Asp Arg Tyr Glu Ala Glu Ala Leu Leu Glu Gly Lys Pro Glu 
385                 390                 395                 400 


Gly Thr Phe Leu Leu Arg Asp Ser Ala Gln Glu Asp Tyr Leu Phe Ser 
                405                 410                 415     


Val Ser Phe Arg Arg Tyr Asn Arg Ser Leu His Ala Arg Ile Glu Gln 
            420                 425                 430         


Trp Asn His Asn Phe Ser Phe Asp Ala His Asp Pro Cys Val Phe His 
        435                 440                 445             


Ser Ser Thr Val Thr Gly Leu Leu Glu His Tyr Lys Asp Pro Ser Ser 
    450                 455                 460                 


Cys Met Phe Phe Glu Pro Leu Leu Thr Ile Ser Leu Asn Arg Thr Phe 
465                 470                 475                 480 


Pro Phe Ser Leu Gln Tyr Ile Cys Arg Ala Val Ile Cys Arg Cys Thr 
                485                 490                 495     


Thr Tyr Asp Gly Ile Asp Gly Leu Pro Leu Pro Ser Met Leu Gln Asp 
            500                 505                 510         


Phe Leu Lys Glu Tyr His Tyr Lys Gln Lys Val Arg Val Arg Trp Leu 
        515                 520                 525             


Glu Arg Glu Pro Val Lys Ala Lys 
    530                 535     

<210>  1444
<211>  5325
<212>  DNA
<213>  Homo sapiens

<400>  1444
attctggtgg gggttggggg gaggggggag gggaaacggg tgaagaaggg gaggcggcag     60

ggaagggggt gggggcctgg cgggggcatc cggcggagct ggggtccccg ggctccgtcc    120

ggaggaagcg acgctgcgct cgctgggcag tcggagggga cgggacgcac cggagggcag    180

gcggactcgc cctgtcggtg actgcgccgt ccgggcccgt cctgcctggc cgcaggtgcc    240

ctggatgagg ccgccccgcg cgccccaaac gattttataa tcaatggata aagtgggaaa    300

aatgtggaat aacttcaaat acaggtgtca gaatctcttc ggtcatgagg gaggaagccg    360

tagtgaaaat gtggacatga actccaacag atgtttgtct gtcaaagaga aaaacatcag    420

cataggagac tcaactcctc agcaacaaag cagtccctta agagaaaata ttgccttaca    480

actgggatta agcccttcga agaattcttc aaggagaaat caaaattgtg ccacagaaat    540

ccctcaaatt gttgaaataa gcatcgaaaa ggataatgat tcttgtgtta ccccaggaac    600

aagacttgca cgaagagatt cctactctcg acatgctcca tggggtggga agaaaaaaca    660

ttcctgttct acaaagaccc agagttcatt ggatgctgat aaaaagtttg gtagaactcg    720

aagtggactt caaaggagag agaggcgcta cggcgtaagt tctgtacacg acatggacag    780

tgtttccagc agaactgtag gaagtcgctc tctaagacag aggttgcagg atactgtggg    840

cttgtgtttt cccatgagaa cttacagcaa gcagtcaaag cctctctttt ccaataaaag    900

aaaaatccat ctctctgaat taatgcttga gaaatgccct tttcctgctg gctcagattt    960

agcccaaaaa tggcatttga ttaaacagca tacagctcct gtgagcccac attcaacatt   1020

ttttgataca tttgatccat ctttggtttc tacagaagat gaagaagata ggcttagaga   1080

gagaaggcgg cttagtattg aagaaggggt tgatccccct cccaatgcac aaatacatac   1140

atttgaagct actgcacagg ttaatccatt atataaactg ggaccaaaat tagctcctgg   1200

aatgactgaa ataagtgggg acagttctgc aattccacaa gctaattgtg actcggaaga   1260

ggatacaacc accctgtgtt tgcagtcacg gaggcagaag cagcgtcaga tatctggaga   1320

cagccatacc catgttagca gacagggagc ttggaaagtc cacacacaga ttgattacat   1380

acactgcctc gtgcctgatt tgcttcaaat tacagggaat ccctgttact ggggagtgat   1440

ggaccgttat gaagcagaag cccttctcga agggaaacct gaaggcacgt ttttgctcag   1500

ggactctgcg caagaggact acctcttctc tgtgagcttc cgccgctaca acagatccct   1560

gcatgcccga attgagcagt ggaatcacaa ctttagtttc gacgcccatg acccgtgtgt   1620

atttcactcc tccactgtaa cgggactttt agaacattat aaagatccca gttcgtgcat   1680

gttttttgaa ccattgctta ctatatcact aaataggact ttccctttta gcctgcagta   1740

tatctgtcgc gcggtaatct gcaggtgcac tacgtatgat ggaattgatg ggctccctct   1800

accctcaatg ttacaggatt ttttaaaaga gtatcattat aaacaaaaag ttagagttcg   1860

ctggttggaa cgagaaccag tcaaggcaaa gtaaactctc cggtccccaa aggttgttaa   1920

ctaggtccgc tttcatgtgc atcagacagt acacctatag caagcacacg tagcagtgtt   1980

aggctttttc atacagtatg taagcttagt gttagtatct gtcagatgct acctgctgtt   2040

acttattcag ataaacatgg tgcctattgg aacaatagcg gatagagcta caggtgttca   2100

gtaagactac aaaaacattt tgcctatttc gctaacagtt tggtttttaa tggctgtggt   2160

atttgagtga ggcaactctg gggcatttgt tatgaagaat tctatttctt actgaagaac   2220

aaattattaa tattggatga gtatttcaac agtgtgacta atgtttgaaa ttattttttc   2280

taagagtttt tctataacct tccaaaagtc gtgatgtttg tagttactat aaatcaagct   2340

ttggaagtcc aaaaagaata aaagactgcc ttccttttag aaaaaaatgc aattttctgg   2400

ccacaagggc atagtgcagt tcacttacgt gttgatgtag tttataatca gacgcctttt   2460

ctcttctgca aaaggtactg ttaagtaaac cagattttct aaataggcat tcttaaaatt   2520

tcagacttac aaagctagta gtagaatttt attgaaaggc ctaggtatta attttttaaa   2580

tgagtgcttt aacttaaaac aggcgtttgg aatagctgct gcaatgtagt cttgtgtgtg   2640

attttttttt aagttgatgt gcagtctaat tgttgtttca taaaagttgg atctgttcct   2700

atgcccagga tgattttgtg aaccgtgaag tacgtgagac tagaagacgc ccaaacaagt   2760

cagataatag taactacaat ggttgctgat gttgagatta ttgttgaact ataattaata   2820

atttggatgg cagaatttat ctcttttttg taaactctca taactgaatt gcttaagtat   2880

aatttataga atttcagtgc agttcattct taatggaaaa tctgaaacct aaattgcaga   2940

tttaaaaggt actgtacaac cattatatct gtaaataact tagcaccttt ttgtcactta   3000

gaataatatg tactactact tgagtgagcg cttttggaag ttatatcaag ttctagtgtt   3060

tgcttcttag taactgaact gaatttacag ttctgtccta gacattttgc actaaagtag   3120

ccgaatccac tctcatgtct tttcgttaat gtgctctgta ccactggtga gtgctccata   3180

gtttccttac ctgctgctac agaatgttat tttacatccc tatggctatt gccaaggcta   3240

caaaaaagga aagctatatt tgtatgcaac actaaccttt tgactgctaa tgtatgtttc   3300

tgcttgctgt gccttgttat ggctgctttt tttgtgctaa taaagtatgt ttggtgttct   3360

ccttgtatat ctgctgtttt atacatttgc aacaatttct cttgtaaatg gaatggtttg   3420

gggtttttaa ataagcatta actaacaacc tttctatagt taatgcagag ttaatgaaca   3480

gtctaatatt gacttatcag aataagctaa ctctaaattt aatgctctac atcttatcag   3540

tcataattat atatactgtg gaacagtatc tgtagttact gcaaattact gtacagttta   3600

ggttataaca gaaaactgac agagaagtaa taaacctatt gatttctctg cttataaatg   3660

aaagattgaa actatccaat gacatattat agtaaatgag tatctgtaac ctcccactgc   3720

atcagaagca ggttaaatga agtcttgtga atttgtaata gatcagtacc atttattggt   3780

ttggggacca tcttaattaa aaataaatgc ccaaaatgta gaactttaac caaagacttg   3840

tcccttttaa agcaaaatgg ggattgaagg gacttataat ttctgttgtt tctaattaaa   3900

gtccctgaag atcatatacc aaagtgtttg agaacttcat ccaaacctac tttaaagcat   3960

tatgtgcaat taagttgtta tgacataatt atattgccta attgttgggt cttttttctt   4020

gagcttataa tgtacctgga aaataaacct cttgagaaaa agaaaagttc atactgatta   4080

ttggaaaagg actatatatg tgagcaagat tgtgttttag agaggaaact tgaaactcca   4140

agaaagcact tgatgttttt atatgcttgt agcaaattga tgttctaact gtagttttat   4200

agaaagtatt aatgctttta tgtatttcaa aactttcata tgttaaatgg aaattgtttt   4260

aaatgtgttt gagtttatgt aagcatgtat acactgtgct aaaagtcaca tgtttcagtt   4320

tgtgtataat attaatatgc aatttttggt ttaaattttt gtcttaaaat attagtggct   4380

tacattttaa aaaagaaaaa tcaccagcat gaacttgcac ctaagtctat attcactgtg   4440

tccttttctg aatcccattg tagcctgtca actaaatttg agtgttaacg gtctttttaa   4500

agtgcattta aatacaaacc aggaatttct ttagaagttg agatacatct ttatagttga   4560

aataattaac ccaagaaaag gttgctttga tttgtaccca ttctcattca ttttcttcat   4620

tcccttacac acacacacac acctctccct tccgcataca tataagtgtg tattatatat   4680

ttatgtatgc acatatatac atttatgttg ttaatattac tttagatggc atttccacct   4740

gatacaaaaa catttagaga tcttattcta tagatattac ctaaagagta ttcttgtact   4800

attcgaattt tattatctgc actaaaagtt tagccttgct actttagcct tgtttataat   4860

acagtcacct tacaaagaga aagagttcat ctgtattttg ttttctggct aaacacagta   4920

caaaatattt gaagaaaaac agcttggatt aaatagttac taagagttat aattaaattt   4980

atgtttctta gacaaaactt gagcccaaat aatcattctc cacacaccag gctgttttta   5040

gctcttatgt ttacgtaaga tttataatgg ctagaaccgt aagaactgat acttgaattt   5100

taagcttcat ttgacaaaat cgaaagctta agaatttttt tatttcacat tttgatctgg   5160

ttgctattta tgtttatttc aaagcttgct tttctctctg gcactgaaca ctaatttggt   5220

gagttttatt gagactggtc ttagatctct tatttttata gcaaatactg ctttttggta   5280

gagccaaaga gcctgtgagt gaatcaggac cctccttttt ttttg                   5325


<210>  1445
<211>  536
<212>  PRT
<213>  Homo sapiens

<400>  1445


Met Asp Lys Val Gly Lys Met Trp Asn Asn Phe Lys Tyr Arg Cys Gln 
1               5                   10                  15      


Asn Leu Phe Gly His Glu Gly Gly Ser Arg Ser Glu Asn Val Asp Met 
            20                  25                  30          


Asn Ser Asn Arg Cys Leu Ser Val Lys Glu Lys Asn Ile Ser Ile Gly 
        35                  40                  45              


Asp Ser Thr Pro Gln Gln Gln Ser Ser Pro Leu Arg Glu Asn Ile Ala 
    50                  55                  60                  


Leu Gln Leu Gly Leu Ser Pro Ser Lys Asn Ser Ser Arg Arg Asn Gln 
65                  70                  75                  80  


Asn Cys Ala Thr Glu Ile Pro Gln Ile Val Glu Ile Ser Ile Glu Lys 
                85                  90                  95      


Asp Asn Asp Ser Cys Val Thr Pro Gly Thr Arg Leu Ala Arg Arg Asp 
            100                 105                 110         


Ser Tyr Ser Arg His Ala Pro Trp Gly Gly Lys Lys Lys His Ser Cys 
        115                 120                 125             


Ser Thr Lys Thr Gln Ser Ser Leu Asp Ala Asp Lys Lys Phe Gly Arg 
    130                 135                 140                 


Thr Arg Ser Gly Leu Gln Arg Arg Glu Arg Arg Tyr Gly Val Ser Ser 
145                 150                 155                 160 


Val His Asp Met Asp Ser Val Ser Ser Arg Thr Val Gly Ser Arg Ser 
                165                 170                 175     


Leu Arg Gln Arg Leu Gln Asp Thr Val Gly Leu Cys Phe Pro Met Arg 
            180                 185                 190         


Thr Tyr Ser Lys Gln Ser Lys Pro Leu Phe Ser Asn Lys Arg Lys Ile 
        195                 200                 205             


His Leu Ser Glu Leu Met Leu Glu Lys Cys Pro Phe Pro Ala Gly Ser 
    210                 215                 220                 


Asp Leu Ala Gln Lys Trp His Leu Ile Lys Gln His Thr Ala Pro Val 
225                 230                 235                 240 


Ser Pro His Ser Thr Phe Phe Asp Thr Phe Asp Pro Ser Leu Val Ser 
                245                 250                 255     


Thr Glu Asp Glu Glu Asp Arg Leu Arg Glu Arg Arg Arg Leu Ser Ile 
            260                 265                 270         


Glu Glu Gly Val Asp Pro Pro Pro Asn Ala Gln Ile His Thr Phe Glu 
        275                 280                 285             


Ala Thr Ala Gln Val Asn Pro Leu Tyr Lys Leu Gly Pro Lys Leu Ala 
    290                 295                 300                 


Pro Gly Met Thr Glu Ile Ser Gly Asp Ser Ser Ala Ile Pro Gln Ala 
305                 310                 315                 320 


Asn Cys Asp Ser Glu Glu Asp Thr Thr Thr Leu Cys Leu Gln Ser Arg 
                325                 330                 335     


Arg Gln Lys Gln Arg Gln Ile Ser Gly Asp Ser His Thr His Val Ser 
            340                 345                 350         


Arg Gln Gly Ala Trp Lys Val His Thr Gln Ile Asp Tyr Ile His Cys 
        355                 360                 365             


Leu Val Pro Asp Leu Leu Gln Ile Thr Gly Asn Pro Cys Tyr Trp Gly 
    370                 375                 380                 


Val Met Asp Arg Tyr Glu Ala Glu Ala Leu Leu Glu Gly Lys Pro Glu 
385                 390                 395                 400 


Gly Thr Phe Leu Leu Arg Asp Ser Ala Gln Glu Asp Tyr Leu Phe Ser 
                405                 410                 415     


Val Ser Phe Arg Arg Tyr Asn Arg Ser Leu His Ala Arg Ile Glu Gln 
            420                 425                 430         


Trp Asn His Asn Phe Ser Phe Asp Ala His Asp Pro Cys Val Phe His 
        435                 440                 445             


Ser Ser Thr Val Thr Gly Leu Leu Glu His Tyr Lys Asp Pro Ser Ser 
    450                 455                 460                 


Cys Met Phe Phe Glu Pro Leu Leu Thr Ile Ser Leu Asn Arg Thr Phe 
465                 470                 475                 480 


Pro Phe Ser Leu Gln Tyr Ile Cys Arg Ala Val Ile Cys Arg Cys Thr 
                485                 490                 495     


Thr Tyr Asp Gly Ile Asp Gly Leu Pro Leu Pro Ser Met Leu Gln Asp 
            500                 505                 510         


Phe Leu Lys Glu Tyr His Tyr Lys Gln Lys Val Arg Val Arg Trp Leu 
        515                 520                 525             


Glu Arg Glu Pro Val Lys Ala Lys 
    530                 535     

<210>  1446
<211>  278
<212>  DNA
<213>  Homo sapiens

<400>  1446
tgtagcttgt atgcacacgg gccaagcagc attgccctct ttcgaaactt tctcaccctt     60

gagtcagccc ttgctatgca tttctatcta atttcatcaa agtaaaactg tatgtgctgg    120

gaggaaaggt gtctttaaac ttcccaattc tttaatcctg gaagagttgg gaaactgtaa    180

taaagtaata gagaaaggct atgatactgt agtactcgca aaaacaaaaa ccaaaaacat    240

acaatttggc atctttattc ttgttcctta aaaaaaaa                            278


<210>  1447
<211>  59
<212>  PRT
<213>  Homo sapiens

<400>  1447


Phe His Gln Ser Lys Thr Val Cys Ala Gly Arg Lys Gly Val Phe Lys 
1               5                   10                  15      


Leu Pro Asn Ser Leu Ile Leu Glu Glu Leu Gly Asn Cys Asn Lys Val 
            20                  25                  30          


Ile Glu Lys Gly Tyr Asp Thr Val Val Leu Ala Lys Thr Lys Thr Lys 
        35                  40                  45              


Asn Ile Gln Phe Gly Ile Phe Ile Leu Val Pro 
    50                  55                  

<210>  1448
<211>  765
<212>  DNA
<213>  Homo sapiens

<400>  1448
ggaacagggg atcctctggt cagtctaggt cccctaccca tctctatgtg cggtgtgagg     60

tgctctgccc tacccacact gagggagtga ccttagttaa acagagacta gggaaagaat    120

gccaggaagc gggacaacac ctacctacta cctggactgc aaaaagaggg tgctcatgct    180

atcttaagtg aaaggaatct ccaggacaga ggcatgaaaa tgtgtccgga attggtgggt    240

tcttggtctc actgacttca agaatgaagc cgtggacact cgcagtgagt gttacagctc    300

ttaaggtggc gcgtctggag tttgttcctt ctgatgttcg gatatgttcg gagtttcttc    360

cttgtcgtgg gttcgtggtc tcgctggctc aggagtgaag ctgcatacct tcgcggggca    420

tttggggaga gaagaagctg ggtcacatgc caggaatgct tcagtaactg catcccagga    480

attaccaaat tagccaaagc tcatgcagag ccatctcccc actactgctg gggtgcctga    540

cagggagagg ttctggagag cctggagctc cctcaccaag aagaaagcat gaggagggga    600

ggggctgggg aaggggaggg accaggaaac tcctcctctc cagagtctgc ccctgggaga    660

agagggcaga gtgccaccca gacacctcgc ttgtccactc atgcttgagg gtgtcaagtt    720

gtctcttgca gtgcagacaa gctgcaccaa agtgtccaca ctctc                    765


<210>  1449
<211>  68
<212>  PRT
<213>  Homo sapiens

<400>  1449


Met Phe Gly Tyr Val Arg Ser Phe Phe Leu Val Val Gly Ser Trp Ser 
1               5                   10                  15      


Arg Trp Leu Arg Ser Glu Ala Ala Tyr Leu Arg Gly Ala Phe Gly Glu 
            20                  25                  30          


Arg Arg Ser Trp Val Thr Cys Gln Glu Cys Phe Ser Asn Cys Ile Pro 
        35                  40                  45              


Gly Ile Thr Lys Leu Ala Lys Ala His Ala Glu Pro Ser Pro His Tyr 
    50                  55                  60                  


Cys Trp Gly Ala 
65              

<210>  1450
<211>  1150
<212>  DNA
<213>  Homo sapiens

<400>  1450
ggaacagggg atcctctggt cagtctaggt cccctaccca tctctatgtg cggtgtgagg     60

tgctctgccc tacccacact gagggagtga ccttagttaa acagagacta gggaaagaat    120

gccaggaagc gggacaacac ctacctacta cctggactgc aaaaagaggg tgctcatgct    180

atcttaagtg aaaggaatct ccaggacaga ggcatgaaaa tgtgtccgga attggtgggt    240

tcttggtctc actgacttca agaatgaagc cgtggacact cgcagtgagt gttacagctc    300

ttaaggtggc gcgtctggag tttgttcctt ctgatgttcg gatatgttcg gagtttcttc    360

cttgtcgtgg gttcgtggtc tcgctggctc aggagtgaag ctgcatacct tcgcgggaat    420

gtgacctcag gcagcactgg cgaggggtga acagaaagct cacaataaaa tcatctcatc    480

agaggtcaca gagccaagac gctcctattg aactttcctg ccaagcagaa gcaagattcc    540

atgtcctctc atggcctaga cccctctaag ccacctgcca cagctccgga aatgaacaca    600

gagaaagaag cctagagctg gtggtgcgtc ctggaccctg agacatgggg cataagcagc    660

agaggccact ggccccagga acccggtacc ctgctgtttg tgcactgagc cccacccagt    720

gtcagggcac ctccaaaatg ccaggcactg agtgtcattc ctcagctgct cggcacatcc    780

ttcctccttc aagtcagaaa acagatgctg aaccggcatg gcggtaggtc agggcctccc    840

cggagcctgc caccacagag cctctgcccc aacgggcaca gattacccaa ggtatctccc    900

tcgtccctca gctcattctc ccccgcaaag caggctgccc tccccgtagc taaggtcagg    960

ctgggccttg cactgtgtgc actcttgtcc tgtccacaag gcagctaggg tctgtgacct   1020

tggccagctt cccctgtgga ctcagagagg acggagtggc tttactgcaa tgagtctttg   1080

gggcttggca ccaggtttcc actccccccc gagaaccaag agcatctgaa catggcccgg   1140

cagctatgct                                                          1150


<210>  1451
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  1451


Met Phe Gly Tyr Val Arg Ser Phe Phe Leu Val Val Gly Ser Trp Ser 
1               5                   10                  15      


Arg Trp Leu Arg Ser Glu Ala Ala Tyr Leu Arg Gly Asn Val Thr Ser 
            20                  25                  30          


Gly Ser Thr Gly Glu Gly 
        35              

<210>  1452
<211>  3939
<212>  DNA
<213>  Homo sapiens

<400>  1452
aggcccctgc tagacccatg gaaagctgta tggagattcc acttctccgg ggtttggtag     60

tgattgggcg gggatacctg agagggtgcc aggaaagggt ccagcagtca aagagaaggg    120

gccaaggagt cgataattat gatgagctct ggctttactt gtgcaccttg gtctcctgct    180

cggaaccctt gaaaagaagc tgcagctttt cgaggaatgc aggggcaagc aagactcaca    240

caggcactgg cattcttcta gatccgatgt cccttgcccc accccttact gtggctctgc    300

cttgggtaat cacaacaaat cttcatgact tgcctaggct gtgccaaaaa gatgtaaaag    360

gaacccacca gggtaagatg ccaacttgca gacgacgatc aactgtgtct gacaaggttg    420

ttctggaatc atagttgaag aaacagttgg ctagactcta acagctgttc acaatttctc    480

gtatctctcc tgatggagga cagtgttttt aaagtggcta ctccaaaaat aatcacacaa    540

ggcaggattt catctatccc taatattctc agaaggttca tcagtggcat gatgacagaa    600

aaagtgctac aaaagccatg tgaagaagta catgtttgct tccccttctg tcatgattgt    660

aagtttcctg aggcctccag agccatgctg aactaaacct tgtgattaca ttgagcctac    720

ctgaatgatc caggataatc gtcccatatc aaggagagca aagtgaatag tgtgatttgc    780

ttagaggaca atgctgctac aaaaacctgt tccactccaa ggccaactgc agttttgaga    840

tgtttgagtt gctcccagtt ttatgctacc atgaatgaga ggacggatcc aacattcaaa    900

tggtcttggg tctgcatctt agctcggcca ctggatagct gtacaactac ggagtcttgc    960

tctgttgccc aggctggagt gcagtggcgc gatctcgact cactacaact tccgcctccc   1020

ggattcaagc gattctcctg ccttagcctc ccgagcagct ggaactacag gcacgtgcca   1080

ccacgcccag ctaatttttt tgtattttta gtagagacgg ggtttcacca tgttagccag   1140

gatggtctca attgttctgg agtctttctc taatacacta catacaatcc ataggcaaat   1200

tctgttggcg tcaccttcga aatctacccc aaatcttact atttttacag cacttcaacc   1260

accagtacct tatcaaaaac cacttctata tttcttgtaa attattggaa cagcccttta   1320

cctggtcttc ctgtttctgc cttttgcatc ccttcttcct tcctctcctc cacacatacc   1380

actaaaatcg cagcattgca actacagtaa taaatacatc acttctctgc acaaaagctt   1440

ctggtggctt cccccctcac tcaggaagtc tttatagtac tccagaagat cactttctgg   1500

ccttccctgt tgggctcatt ttctatttct accttgccca ctctgttgca gccacactgt   1560

cctccctgct gattcgtgaa cacactgacc atgctcttgc ttcaagaaca cttacattgc   1620

tgttccctct gccaggacag ttcctctagt atccactcac ctcattcagt ttctgcacaa   1680

atgtcacttt tacaataaag tcatccctaa agaactaatt taaaattgta ccctactaaa   1740

tagaaatccc cttacctcac ttagaacact ctaaaagtgc tctaaaggac taaattagca   1800

atttagccct ttagtacccc actgattagc aatcccctta ccccacttag agagtgctct   1860

actagtactt taggtagtac catctaaaca gtgatgccac tgtcagacta aaaatcacca   1920

tcataggtag atacattaat ttaaatcaga taaacgtaat catctaattt gaacattata   1980

tttcatctac aatatccact tattcaacag gtatttattg accatgctgt acaattttct   2040

aggtgcagaa gatacatcac ttaacaaaga agatcactac acttggttac ttggagttta   2100

tatttgaatt ggtaaaatat atggcagaaa ctgaaagtgc tgagaaggac caaattagta   2160

atgagtaatt tagcccttta gtgccctact gattagcaat cctcttaccc cacttataga   2220

gtgctcttct agtactttag atagcagcat ctaaacagta gcatctaaac cccttgggat   2280

tgctaattac cctactttag gaggtaatta catgaggatg gtgaagcctt tatggaagga   2340

attagggtcc ttataaaagc acttgaggca gtgggtccac tctcttttgc tcttccacca   2400

tgtgaggaca cagcattcaa agcaccacct tggaagcaga gataaggctc tcaccagaca   2460

ccaaacctgc ctgccccttg attttggaca tccagccttc agaactgtga gaagtacatt   2520

tctattattt atgaattacc cagtctggta ttttattata gcagcataaa gagactgtga   2580

tagaaggtat gaatttttgt tctaaacgag gactgggggt ggtaggaact tgaaaacaac   2640

gctaatataa caaatcaatt agattgcttc tagctatttt atttttcttt cattaattag   2700

taattccaat ccagttctgg gtgtgaagtt ctacaggtaa aacatgttcc ttttagatat   2760

tttcctctga aaagaattgg ggaaatattg caaaggaaaa ggaaaaggga aaggagtgat   2820

tctgacattt atgaatttgt gatattatgt actgaaatta tgacctgatt gtatatttct   2880

ccctagtctg catataggga ggttattcag cccttccacc ttctgccatg ggatggcaca   2940

gcaagaaggc cctcatcaga tacaggccct tcagccttgg ttttccagtc attagaactc   3000

attgccatct atattttcac tcctgagaag tttgaaaatt aaaaaaaaaa aaaaagatca   3060

tcaagaataa gggatgaacc acaaaaagaa agaaaggctg gaaaaaggtt ttacagattt   3120

ttaagaaata taactcattt gcctgagcat tctttcaaca tcctcatttt aaggttactt   3180

ctaaaaagaa gaaatgattt ttaatatttc cttcatctgg agaaataact gtcgctgttc   3240

ggtattcaca gacttcctgc tgaggactgc tatcgcaata aactctggtc tcacgatagg   3300

cagccatgat gagaaacggc ccctgcatag agatggtttg aactgtgtgg ctccctcctg   3360

ccccatataa ccatcgcgag aagaatgtaa cagcggccct ccattagtga accttttacc   3420

gtgattcccg agtcataacc ccgacccacc ttgaaatcta ctgctggcat tttctcgtca   3480

ttggtttgac acatgaatta gcagtttaag actttgcctc cctactaaca ccaacatctt   3540

atttgtatgg ctctggcact agttcctgcc tccttgtcct ctaactctaa tcccagttat   3600

cacccttaat tcagtatgct cttggatctc tggttaaatc tcttagaact ttccattcaa   3660

aataacatac tttatacttc agagccaccc ttaggtttgg tacttctact atgtccatga   3720

attgaatttt tgcatctgtt tctctatata tgtatttttc atttaaaata tttgttctta   3780

agtcgtataa tttacctggt gaaagaccat acaacagtac ttgcatgtag tctccctata   3840

actgatgaac gtgcatgttt cttttctccg ataaatttta tgtcaatttt actacattat   3900

tgaaattccc ccagcgtaat gtgataaaat ttatcaact                          3939


<210>  1453
<211>  138
<212>  PRT
<213>  Homo sapiens

<400>  1453


Met Glu Ser Cys Met Glu Ile Pro Leu Leu Arg Gly Leu Val Val Ile 
1               5                   10                  15      


Gly Arg Gly Tyr Leu Arg Gly Cys Gln Glu Arg Val Gln Gln Ser Lys 
            20                  25                  30          


Arg Arg Gly Gln Gly Val Asp Asn Tyr Asp Glu Leu Trp Leu Tyr Leu 
        35                  40                  45              


Cys Thr Leu Val Ser Cys Ser Glu Pro Leu Lys Arg Ser Cys Ser Phe 
    50                  55                  60                  


Ser Arg Asn Ala Gly Ala Ser Lys Thr His Thr Gly Thr Gly Ile Leu 
65                  70                  75                  80  


Leu Asp Pro Met Ser Leu Ala Pro Pro Leu Thr Val Ala Leu Pro Trp 
                85                  90                  95      


Val Ile Thr Thr Asn Leu His Asp Leu Pro Arg Leu Cys Gln Lys Asp 
            100                 105                 110         


Val Lys Gly Thr His Gln Gly Lys Met Pro Thr Cys Arg Arg Arg Ser 
        115                 120                 125             


Thr Val Ser Asp Lys Val Val Leu Glu Ser 
    130                 135             

<210>  1454
<211>  622
<212>  DNA
<213>  Homo sapiens

<400>  1454
agctttgcat gttagcagac tttgttattt cacttatctt tagagacaca tttatatcag     60

aaaatttaac ttgatgatta aaaaaattgg tgaaatacgt gtagactttt gtaactggat    120

tatagtttca tctaagaact cactaaaaat atattgaact tcaggaagag atttttaaat    180

ggctttggta agccatttaa aagccttatt ttcccaaacg aattagtgtt ggtgtgtgga    240

tgaggaactt tgctgttatt ctgtgagcat tacctgataa gaactaatca gatgacagat    300

ggaatctgaa gcttgttctg atgaattttt gaggctggaa tgcaatggcg tgattatagc    360

tcaatgcatc ttcatctccc tgggctcaag caatcttcca agctcagcct cccaagtagc    420

tggaactaca ggaaaggaga atggtttgaa aatggtaatg aggagaaaga atgacactga    480

caccagctcc aggtcccgtg gaatgaaatc tatgacagtt tcttgctctg tcacccaggc    540

tggagtgtaa tggtgtgatc ctagctcacg gcagccttga attcccagga tcaagtgatt    600

ctcccacctc agcttctgga gt                                             622


<210>  1455
<211>  83
<212>  PRT
<213>  Homo sapiens

<400>  1455


Met Glu Ser Glu Ala Cys Ser Asp Glu Phe Leu Arg Leu Glu Cys Asn 
1               5                   10                  15      


Gly Val Ile Ile Ala Gln Cys Ile Phe Ile Ser Leu Gly Ser Ser Asn 
            20                  25                  30          


Leu Pro Ser Ser Ala Ser Gln Val Ala Gly Thr Thr Gly Lys Glu Asn 
        35                  40                  45              


Gly Leu Lys Met Val Met Arg Arg Lys Asn Asp Thr Asp Thr Ser Ser 
    50                  55                  60                  


Arg Ser Arg Gly Met Lys Ser Met Thr Val Ser Cys Ser Val Thr Gln 
65                  70                  75                  80  


Ala Gly Val 
            

<210>  1456
<211>  2137
<212>  DNA
<213>  Homo sapiens

<400>  1456
agctcccatg cagcccacag ccctaaaggc cggtttcact cccaccatgc cccaccaaca     60

gcaatgagtt tacttccagg aagctggtga gcagggctga gaacttgctc caggctacaa    120

gcctcccagc tgagaaaacg agcgaactca cagttcctcg actgtcccat ggagcctgca    180

gtggcaatcc gcctccttca aagggtctgt ggactttctc ggctttcctg gaattagcag    240

ttcacaaagc acattcgcat ataagggctt gttttgaatt gatcttggca gcaattctat    300

gagacaagta aaagcacaag aggaatagga actgcacctc ttccttcagt ttcagcttga    360

ataatatcag gaagattcgt atcggtctga gttgggtcac gtacccgacg tgctatagct    420

gaggatgggc tgacttgtat gaagaaggag gtggaggagg aggagaaggt gaagacaatg    480

ctgactcaaa ggggggatta taaaactaat catcaaagcc aagaaggcaa gagcaagcat    540

gtaccgctga aaacacaaga taactgcata agtaatgact ttcagtgcag attcatagct    600

aacccataaa ctgctggggc aaaaatcatc ttggaaggct ctgaacctca gaaaggattc    660

acaagacgat ctgccgaccc tctgggagaa aatccagcaa gatgcaagcc ttcagaatct    720

gggatgttaa ccagaagacc ttctatctga ggaacaacca actagttgct ggatacttgc    780

aaggaccaaa tgtcaattta gaagaaaaga tagatgtggt acccattgag cctcatgctc    840

tgttcttggg aatccatgga gggaagatgt gcctgtcctg tgtcaagtct ggtgatgaga    900

ccagactcca gctggaggca gttaacatca ctgacctgag cgagaacaga aagcaggaca    960

agcgcttcgc cttcatccgc tcagacagtg gccccaccac cagttttgag tctgccgcct   1020

gccccggttg gttcctctgc acagcgatgg aagctgacca gcccgtcagc ctcaccaata   1080

tgcctgacga aggcgtcatg gtcaccaaat tctacttcca ggaggacgag tagtactgcc   1140

caggcctgcc tgttcccatt cttgcatggc aaggactgca gggactgcca gtccccctgc   1200

cccagggctc ccggctatgg gggcactgag gaccagccat tgaggggtgg accctcagaa   1260

ggcgtcacaa caacctggtc acaggactct gcctcctctt caactgacca gcctccatgc   1320

tgcctccaga atggtctttc taatgtgtga atcagagcac agcagcccct gcacaaagcc   1380

cttccatgtc gcctctgcat tcaggatcaa accccgacca cctgcccaac ctgctctcct   1440

cttgccactg cctcttcctc cctcattcca ccttcccatg ccctggatcc atcaggccac   1500

ttgatgaccc ccaaccaagt ggctcccaca ccctgtttta caaaaaagaa aagaccagtc   1560

catgagggag gtttttaagg gtttgtggaa aatgaaaatt aggatttcat gatttttttt   1620

tttcagtccc cgtgaaggag agcccttcat ttggagatta tgttctttcg gggagaggct   1680

gaggacttaa aatattcctg catttgtgaa atgatggtga aagcactgct gcccagcctc   1740

caagctccat ctccactcca gattttttac agctgcctgc agtactttac ctcctatcag   1800

aagtttctca gctcccaagg ctctgagcaa atgtggctcc tgggggttct ttcttcctct   1860

gctgaaggaa taaattgctc cttgacattg tagagcttct ggcacttgga gacttgtatg   1920

aaagatggct gtgcctctgc ctgtctcccc caccgggctg ggagctctgc agagcaggaa   1980

acatgactcg tatatgtctc aggtccctgc agggccaagc acctagcctc gctcttggca   2040

ggtactcagc gaatgaatgc tgtatatgtt gggtgcaaag ttccctactt cctgtgactt   2100

cagctctgtt ttacaataaa atcttgaaaa tgcctat                            2137


<210>  1457
<211>  143
<212>  PRT
<213>  Homo sapiens

<400>  1457


Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu 
1               5                   10                  15      


Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn 
            20                  25                  30          


Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala Leu Phe 
        35                  40                  45              


Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val Lys Ser Gly 
    50                  55                  60                  


Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp Leu Ser 
65                  70                  75                  80  


Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser 
                85                  90                  95      


Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp Phe Leu 
            100                 105                 110         


Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn Met Pro 
        115                 120                 125             


Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
    130                 135                 140             

<210>  1458
<211>  1753
<212>  DNA
<213>  Homo sapiens

<400>  1458
gggcagctcc accctgggag ggactgtggc ccaggtactg cccgggtgct actttatggg     60

cagcagctca gttgagttag agtctggaag acctcagaag acctcctgtc ctatgaggcc    120

ctccccatgg ctttagagac gatctgccga ccctctggga gaaaatccag caagatgcaa    180

gccttcagaa tctgggatgt taaccagaag accttctatc tgaggaacaa ccaactagtt    240

gctggatact tgcaaggacc aaatgtcaat ttagaagaaa agatagatgt ggtacccatt    300

gagcctcatg ctctgttctt gggaatccat ggagggaaga tgtgcctgtc ctgtgtcaag    360

tctggtgatg agaccagact ccagctggag gcagttaaca tcactgacct gagcgagaac    420

agaaagcagg acaagcgctt cgccttcatc cgctcagaca gtggccccac caccagtttt    480

gagtctgccg cctgccccgg ttggttcctc tgcacagcga tggaagctga ccagcccgtc    540

agcctcacca atatgcctga cgaaggcgtc atggtcacca aattctactt ccaggaggac    600

gagtagtact gcccaggcct gcctgttccc attcttgcat ggcaaggact gcagggactg    660

ccagtccccc tgccccaggg ctcccggcta tgggggcact gaggaccagc cattgagggg    720

tggaccctca gaaggcgtca caacaacctg gtcacaggac tctgcctcct cttcaactga    780

ccagcctcca tgctgcctcc agaatggtct ttctaatgtg tgaatcagag cacagcagcc    840

cctgcacaaa gcccttccat gtcgcctctg cattcaggat caaaccccga ccacctgccc    900

aacctgctct cctcttgcca ctgcctcttc ctccctcatt ccaccttccc atgccctgga    960

tccatcaggc cacttgatga cccccaacca agtggctccc acaccctgtt ttacaaaaaa   1020

gaaaagacca gtccatgagg gaggttttta agggtttgtg gaaaatgaaa attaggattt   1080

catgattttt ttttttcagt ccccgtgaag gagagccctt catttggaga ttatgttctt   1140

tcggggagag gctgaggact taaaatattc ctgcatttgt gaaatgatgg tgaaagtaag   1200

tggtagcttt tcccttcttt ttcttctttt tttgtgatgt cccaacttgt aaaaattaaa   1260

agttatggta ctatgttagc cccataattt tttttttcct tttaaaacac ttccataatc   1320

tggactcctc tgtccaggca ctgctgccca gcctccaagc tccatctcca ctccagattt   1380

tttacagctg cctgcagtac tttacctcct atcagaagtt tctcagctcc caaggctctg   1440

agcaaatgtg gctcctgggg gttctttctt cctctgctga aggaataaat tgctccttga   1500

cattgtagag cttctggcac ttggagactt gtatgaaaga tggctgtgcc tctgcctgtc   1560

tcccccaccg ggctgggagc tctgcagagc aggaaacatg actcgtatat gtctcaggtc   1620

cctgcagggc caagcaccta gcctcgctct tggcaggtac tcagcgaatg aatgctgtat   1680

atgttgggtg caaagttccc tacttcctgt gacttcagct ctgttttaca ataaaatctt   1740

gaaaatgcct ata                                                      1753


<210>  1459
<211>  159
<212>  PRT
<213>  Homo sapiens

<400>  1459


Met Ala Leu Glu Thr Ile Cys Arg Pro Ser Gly Arg Lys Ser Ser Lys 
1               5                   10                  15      


Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu 
            20                  25                  30          


Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn 
        35                  40                  45              


Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala Leu Phe 
    50                  55                  60                  


Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val Lys Ser Gly 
65                  70                  75                  80  


Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp Leu Ser 
                85                  90                  95      


Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser 
            100                 105                 110         


Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp Phe Leu 
        115                 120                 125             


Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn Met Pro 
    130                 135                 140                 


Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
145                 150                 155                 

<210>  1460
<211>  1816
<212>  DNA
<213>  Homo sapiens

<400>  1460
gggcagctcc accctgggag ggactgtggc ccaggtactg cccgggtgct actttatggg     60

cagcagctca gttgagttag agtctggaag acctcagaag acctcctgtc ctatgaggcc    120

ctccccatgg ctttagctga cttgtatgaa gaaggaggtg gaggaggagg agaaggtgaa    180

gacaatgctg actcaaagga gacgatctgc cgaccctctg ggagaaaatc cagcaagatg    240

caagccttca gaatctggga tgttaaccag aagaccttct atctgaggaa caaccaacta    300

gttgctggat acttgcaagg accaaatgtc aatttagaag aaaagataga tgtggtaccc    360

attgagcctc atgctctgtt cttgggaatc catggaggga agatgtgcct gtcctgtgtc    420

aagtctggtg atgagaccag actccagctg gaggcagtta acatcactga cctgagcgag    480

aacagaaagc aggacaagcg cttcgccttc atccgctcag acagtggccc caccaccagt    540

tttgagtctg ccgcctgccc cggttggttc ctctgcacag cgatggaagc tgaccagccc    600

gtcagcctca ccaatatgcc tgacgaaggc gtcatggtca ccaaattcta cttccaggag    660

gacgagtagt actgcccagg cctgcctgtt cccattcttg catggcaagg actgcaggga    720

ctgccagtcc ccctgcccca gggctcccgg ctatgggggc actgaggacc agccattgag    780

gggtggaccc tcagaaggcg tcacaacaac ctggtcacag gactctgcct cctcttcaac    840

tgaccagcct ccatgctgcc tccagaatgg tctttctaat gtgtgaatca gagcacagca    900

gcccctgcac aaagcccttc catgtcgcct ctgcattcag gatcaaaccc cgaccacctg    960

cccaacctgc tctcctcttg ccactgcctc ttcctccctc attccacctt cccatgccct   1020

ggatccatca ggccacttga tgacccccaa ccaagtggct cccacaccct gttttacaaa   1080

aaagaaaaga ccagtccatg agggaggttt ttaagggttt gtggaaaatg aaaattagga   1140

tttcatgatt tttttttttc agtccccgtg aaggagagcc cttcatttgg agattatgtt   1200

ctttcgggga gaggctgagg acttaaaata ttcctgcatt tgtgaaatga tggtgaaagt   1260

aagtggtagc ttttcccttc tttttcttct ttttttgtga tgtcccaact tgtaaaaatt   1320

aaaagttatg gtactatgtt agccccataa tttttttttt ccttttaaaa cacttccata   1380

atctggactc ctctgtccag gcactgctgc ccagcctcca agctccatct ccactccaga   1440

ttttttacag ctgcctgcag tactttacct cctatcagaa gtttctcagc tcccaaggct   1500

ctgagcaaat gtggctcctg ggggttcttt cttcctctgc tgaaggaata aattgctcct   1560

tgacattgta gagcttctgg cacttggaga cttgtatgaa agatggctgt gcctctgcct   1620

gtctccccca ccgggctggg agctctgcag agcaggaaac atgactcgta tatgtctcag   1680

gtccctgcag ggccaagcac ctagcctcgc tcttggcagg tactcagcga atgaatgctg   1740

tatatgttgg gtgcaaagtt ccctacttcc tgtgacttca gctctgtttt acaataaaat   1800

cttgaaaatg cctata                                                   1816


<210>  1461
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  1461


Met Ala Leu Ala Asp Leu Tyr Glu Glu Gly Gly Gly Gly Gly Gly Glu 
1               5                   10                  15      


Gly Glu Asp Asn Ala Asp Ser Lys Glu Thr Ile Cys Arg Pro Ser Gly 
            20                  25                  30          


Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln 
        35                  40                  45              


Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln 
    50                  55                  60                  


Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu 
65                  70                  75                  80  


Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser 
                85                  90                  95      


Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn 
            100                 105                 110         


Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe 
        115                 120                 125             


Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys 
    130                 135                 140                 


Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser 
145                 150                 155                 160 


Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe 
                165                 170                 175     


Gln Glu Asp Glu 
            180 

<210>  1462
<211>  1924
<212>  DNA
<213>  Homo sapiens

<400>  1462
gggcagctcc accctgggag ggactgtggc ccaggtactg cccgggtgct actttatggg     60

cagcagctca gttgagttag agtctggaag acctcagaag acctcctgtc ctatgaggcc    120

ctccccatgg ctttaggggg attataaaac taatcatcaa agccaagaag gcaagagcaa    180

gcatgtaccg ctgaaaacac aagataactg cataagtaat gactttcagt gcagattcat    240

agctaaccca taaactgctg gggcaaaaat catcttggaa ggctctgaac ctcagaaagg    300

attcacaaga cgatctgccg accctctggg agaaaatcca gcaagatgca agccttcaga    360

atctgggatg ttaaccagaa gaccttctat ctgaggaaca accaactagt tgctggatac    420

ttgcaaggac caaatgtcaa tttagaagaa aagatagatg tggtacccat tgagcctcat    480

gctctgttct tgggaatcca tggagggaag atgtgcctgt cctgtgtcaa gtctggtgat    540

gagaccagac tccagctgga ggcagttaac atcactgacc tgagcgagaa cagaaagcag    600

gacaagcgct tcgccttcat ccgctcagac agtggcccca ccaccagttt tgagtctgcc    660

gcctgccccg gttggttcct ctgcacagcg atggaagctg accagcccgt cagcctcacc    720

aatatgcctg acgaaggcgt catggtcacc aaattctact tccaggagga cgagtagtac    780

tgcccaggcc tgcctgttcc cattcttgca tggcaaggac tgcagggact gccagtcccc    840

ctgccccagg gctcccggct atgggggcac tgaggaccag ccattgaggg gtggaccctc    900

agaaggcgtc acaacaacct ggtcacagga ctctgcctcc tcttcaactg accagcctcc    960

atgctgcctc cagaatggtc tttctaatgt gtgaatcaga gcacagcagc ccctgcacaa   1020

agcccttcca tgtcgcctct gcattcagga tcaaaccccg accacctgcc caacctgctc   1080

tcctcttgcc actgcctctt cctccctcat tccaccttcc catgccctgg atccatcagg   1140

ccacttgatg acccccaacc aagtggctcc cacaccctgt tttacaaaaa agaaaagacc   1200

agtccatgag ggaggttttt aagggtttgt ggaaaatgaa aattaggatt tcatgatttt   1260

tttttttcag tccccgtgaa ggagagccct tcatttggag attatgttct ttcggggaga   1320

ggctgaggac ttaaaatatt cctgcatttg tgaaatgatg gtgaaagtaa gtggtagctt   1380

ttcccttctt tttcttcttt ttttgtgatg tcccaacttg taaaaattaa aagttatggt   1440

actatgttag ccccataatt ttttttttcc ttttaaaaca cttccataat ctggactcct   1500

ctgtccaggc actgctgccc agcctccaag ctccatctcc actccagatt ttttacagct   1560

gcctgcagta ctttacctcc tatcagaagt ttctcagctc ccaaggctct gagcaaatgt   1620

ggctcctggg ggttctttct tcctctgctg aaggaataaa ttgctccttg acattgtaga   1680

gcttctggca cttggagact tgtatgaaag atggctgtgc ctctgcctgt ctcccccacc   1740

gggctgggag ctctgcagag caggaaacat gactcgtata tgtctcaggt ccctgcaggg   1800

ccaagcacct agcctcgctc ttggcaggta ctcagcgaat gaatgctgta tatgttgggt   1860

gcaaagttcc ctacttcctg tgacttcagc tctgttttac aataaaatct tgaaaatgcc   1920

tata                                                                1924


<210>  1463
<211>  143
<212>  PRT
<213>  Homo sapiens

<400>  1463


Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu 
1               5                   10                  15      


Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn 
            20                  25                  30          


Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala Leu Phe 
        35                  40                  45              


Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val Lys Ser Gly 
    50                  55                  60                  


Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp Leu Ser 
65                  70                  75                  80  


Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser 
                85                  90                  95      


Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp Phe Leu 
            100                 105                 110         


Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn Met Pro 
        115                 120                 125             


Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
    130                 135                 140             

<210>  1464
<211>  950
<212>  DNA
<213>  Homo sapiens

<400>  1464
agctcagttg agttagagtc tggaagacct cagaagacct cctgtcctat gaggccctcc     60

ccatggcttt agagacgatc tgccgaccct ctgggagaaa atccagcaag atgcaagcct    120

tcagaatctg ggatgttaac cagaagacct tctatctgag gaacaaccaa ctagttgctg    180

gatacttgca aggaccaaat gtcaatttag aagaaaagat agatgtggta cccattgagc    240

ctcatgctct gttcttggga atccatggag ggaagatgtg cctgtcctgt gtcaagtctg    300

gtgatgagac cagactccag ctggaggcag ttaacatcac tgacctgagc gagaacagaa    360

agcaggacaa gcgcttcgcc ttcatccgct cagacagtgg ccccaccacc agttttgagt    420

ctgccgcctg ccccggttgg ttcctctgca cagcgatgga agctgaccag cccgtcagcc    480

tcaccaatat gcctgacgaa ggcgtcatgg tcaccaaatt ctacttccag gaggacgagt    540

agtactgccc aggcctgcct gttcccattc ttgcatggca aggactgcag ggactgccag    600

tccccctgcc ccagggctcc cggctatggg ggcactgagg accagccatt gaggggtgga    660

ccctcagaag gcgtcacaac aacctggtca caggactctg cctcctcttc aactgaccag    720

cctccatgct gcctccagaa tggtctttct aatgtgtgaa tcagagcaca gcagcccctg    780

cacaaagccc ttccatgtcg cctctgcatt caggatcaaa ccccgaccac ctgcccaacc    840

tgctctcctc ttgccactgc ctcttcctcc ctcattccac cttcccatgc cctggatcca    900

tcaggccact tgatgacccc caaccaagtg gctcccacac cctgttttac               950


<210>  1465
<211>  159
<212>  PRT
<213>  Homo sapiens

<400>  1465


Met Ala Leu Glu Thr Ile Cys Arg Pro Ser Gly Arg Lys Ser Ser Lys 
1               5                   10                  15      


Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu 
            20                  25                  30          


Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn 
        35                  40                  45              


Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala Leu Phe 
    50                  55                  60                  


Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val Lys Ser Gly 
65                  70                  75                  80  


Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp Leu Ser 
                85                  90                  95      


Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser 
            100                 105                 110         


Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp Phe Leu 
        115                 120                 125             


Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn Met Pro 
    130                 135                 140                 


Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
145                 150                 155                 

<210>  1466
<211>  1226
<212>  DNA
<213>  Homo sapiens

<400>  1466
agctcagttg agttagagtc tggaagacct cagaagacct cctgtcctat gaggccctcc     60

ccatggcttt agagacgatc tgccgaccct ctgggagaaa atccagcaag atgcaagcct    120

tcagaatctg ggatgttaac cagaagacct tctatctgag gaacaaccaa ctagttgctg    180

gatacttgca aggaccaaat gtcaatttag aagaaaagat agatgtggta cccattgagc    240

ctcatgctct gttcttggga atccatggag ggaagatgtg cctgtcctgt gtcaagtctg    300

gtgatgagac cagactccag ctggaggcag ttaacatcac tgacctgagc gagaacagaa    360

agcaggacaa gcgcttcgcc ttcatccgct cagacagtgg ccccaccacc agttttgagt    420

ctgccgccct ggatccatca ggccacttga tgacccccaa ccaagtggct cccacaccct    480

gttttacaaa aaagaaaaga ccagtccatg agggaggttt ttaagggttt gtggaaaatg    540

aaaattagga tttcatgatt tttttttttc agtccccgtg aaggagagcc cttcatttgg    600

agattatgtt ctttcgggga gaggctgagg acttaaaata ttcctgcatt tgtgaaatga    660

tggtgaaagt aagtggtagc ttttcccttc tttttcttct ttttttgtga tgtcccaact    720

tgtaaaaatt aaaagttatg gtactatgtt agccccataa tttttttttt ccttttaaaa    780

cacttccata atctggactc ctctgtccag gcactgctgc ccagcctcca agctccatct    840

ccactccaga ttttttacag ctgcctgcag tactttacct cctatcagaa gtttctcagc    900

tcccaaggct ctgagcaaat gtggctcctg ggggttcttt cttcctctgc tgaaggaata    960

aattgctcct tgacattgta gagcttctgg cacttggaga cttgtatgaa agatggctgt   1020

gcctctgcct gtctccccca ccgggctggg agctctgcag agcaggaaac atgactcgta   1080

tatgtctcag gtccctgcag ggccaagcac ctagcctcgc tcttggcagg tactcagcga   1140

atgaatgctg tatatgttgg gtgcaaagtt ccctacttcc tgtgacttca gctctgtttt   1200

acaataaaat cttgaaaatg cctata                                        1226


<210>  1467
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  1467


Met Ala Leu Glu Thr Ile Cys Arg Pro Ser Gly Arg Lys Ser Ser Lys 
1               5                   10                  15      


Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu 
            20                  25                  30          


Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn 
        35                  40                  45              


Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala Leu Phe 
    50                  55                  60                  


Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val Lys Ser Gly 
65                  70                  75                  80  


Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp Leu Ser 
                85                  90                  95      


Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser 
            100                 105                 110         


Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Leu Asp Pro Ser Gly His 
        115                 120                 125             


Leu Met Thr Pro Asn Gln Val Ala Pro Thr Pro Cys Phe Thr Lys Lys 
    130                 135                 140                 


Lys Arg Pro Val His Glu Gly Gly Phe 
145                 150             

<210>  1468
<211>  1613
<212>  DNA
<213>  Homo sapiens

<400>  1468
agctcagttg agttagagtc tggaagacct cagaagacct cctgtcctat gaggccctcc     60

ccatggcttt agagacgatc tgccgaccct ctgggagaaa atccagcaag atgcaagcct    120

tcagaatctg ggatgttaac cagaagacct tctatctgag gaacaaccaa ctagttgctg    180

gatacttgca aggaccaaat gtcaatttag aagaaaagat agatgtggta cccattgagc    240

ctcatgctct gttcttggga atccatggag ggaagatgtg cctgtcctgt gtcaagtctg    300

gtgatgagac cagactccag ctggaggcag ttaacatcac tgacctgagc gagaacagaa    360

agcaggacaa gcgcttcgcc ttcatccgct cagacagtgg ccccaccacc atatgcctga    420

cgaaggcgtc atggtcacca aattctactt ccaggaggac gagtagtact gcccaggcct    480

gcctgttccc attcttgcat ggcaaggact gcagggactg ccagtccccc tgccccaggg    540

ctcccggcta tgggggcact gaggaccagc cattgagggg tggaccctca gaaggcgtca    600

caacaacctg gtcacaggac tctgcctcct cttcaactga ccagcctcca tgctgcctcc    660

agaatggtct ttctaatgtg tgaatcagag cacagcagcc cctgcacaaa gcccttccat    720

gtcgcctctg cattcaggat caaaccccga ccacctgccc aacctgctct cctcttgcca    780

ctgcctcttc ctccctcatt ccaccttccc atgccctgga tccatcaggc cacttgatga    840

cccccaacca agtggctccc acaccctgtt ttacaaaaaa gaaaagacca gtccatgagg    900

gaggttttta agggtttgtg gaaaatgaaa attaggattt catgattttt ttttttcagt    960

ccccgtgaag gagagccctt catttggaga ttatgttctt tcggggagag gctgaggact   1020

taaaatattc ctgcatttgt gaaatgatgg tgaaagtaag tggtagcttt tcccttcttt   1080

ttcttctttt tttgtgatgt cccaacttgt aaaaattaaa agttatggta ctatgttagc   1140

cccataattt tttttttcct tttaaaacac ttccataatc tggactcctc tgtccaggca   1200

ctgctgccca gcctccaagc tccatctcca ctccagattt tttacagctg cctgcagtac   1260

tttacctcct atcagaagtt tctcagctcc caaggctctg agcaaatgtg gctcctgggg   1320

gttctttctt cctctgctga aggaataaat tgctccttga cattgtagag cttctggcac   1380

ttggagactt gtatgaaaga tggctgtgcc tctgcctgtc tcccccaccg ggctgggagc   1440

tctgcagagc aggaaacatg actcgtatat gtctcaggtc cctgcagggc caagcaccta   1500

gcctcgctct tggcaggtac tcagcgaatg aatgctgtat atgttgggtg caaagttccc   1560

tacttcctgt gacttcagct ctgttttaca ataaaatctt gaaaatgcct ata          1613


<210>  1469
<211>  206
<212>  PRT
<213>  Homo sapiens

<400>  1469


Met Ala Leu Glu Thr Ile Cys Arg Pro Ser Gly Arg Lys Ser Ser Lys 
1               5                   10                  15      


Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu 
            20                  25                  30          


Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn 
        35                  40                  45              


Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala Leu Phe 
    50                  55                  60                  


Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val Lys Ser Gly 
65                  70                  75                  80  


Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp Leu Ser 
                85                  90                  95      


Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser 
            100                 105                 110         


Gly Pro Thr Thr Ile Cys Leu Thr Lys Ala Ser Trp Ser Pro Asn Ser 
        115                 120                 125             


Thr Ser Arg Arg Thr Ser Ser Thr Ala Gln Ala Cys Leu Phe Pro Phe 
    130                 135                 140                 


Leu His Gly Lys Asp Cys Arg Asp Cys Gln Ser Pro Cys Pro Arg Ala 
145                 150                 155                 160 


Pro Gly Tyr Gly Gly Thr Glu Asp Gln Pro Leu Arg Gly Gly Pro Ser 
                165                 170                 175     


Glu Gly Val Thr Thr Thr Trp Ser Gln Asp Ser Ala Ser Ser Ser Thr 
            180                 185                 190         


Asp Gln Pro Pro Cys Cys Leu Gln Asn Gly Leu Ser Asn Val 
        195                 200                 205     

<210>  1470
<211>  1904
<212>  DNA
<213>  Homo sapiens

<400>  1470
ctggaagacc tcagaagacc tcctgtccta tgaggccctc cccatggctt tagctgactt     60

gtatgaagaa ggaggtggag gaggaggaga aggtgaagac aatgctgact caaagggggg    120

attataaaac taatcatcaa agccaagaag gcaagagcaa gcatgtaccg ctgaaaacac    180

aagataactg cataagtaat gactttcagt gcagattcat agctaaccca taaactgctg    240

gggcaaaaat catcttggaa ggctctgaac ctcagaaagg attcacaaga cgatctgccg    300

accctctggg agaaaatcca gcaagatgca agccttcaga atctgggatg ttaaccagaa    360

gaccttctat ctgaggaaca accaactagt tgctggatac ttgcaaggac caaatgtcaa    420

tttagaagaa aagatagatg tggtacccat tgagcctcat gctctgttct tgggaatcca    480

tggagggaag atgtgcctgt cctgtgtcaa gtctggtgat gagaccagac tccagctgga    540

ggcagttaac atcactgacc tgagcgagaa cagaaagcag gacaagcgct tcgccttcat    600

ccgctcagac agtggcccca ccaccagttt tgagtctgcc gcctgccccg gttggttcct    660

ctgcacagcg atggaagctg accagcccgt cagcctcacc aatatgcctg acgaaggcgt    720

catggtcacc aaattctact tccaggagga cgagtagtac tgcccaggcc tgcctgttcc    780

cattcttgca tggcaaggac tgcagggact gccagtcccc ctgccccagg gctcccggct    840

atgggggcac tgaggaccag ccattgaggg gtggaccctc agaaggcgtc acaacaacct    900

ggtcacagga ctctgcctcc tcttcaactg accagcctcc atgctgcctc cagaatggtc    960

tttctaatgt gtgaatcaga gcacagcagc ccctgcacaa agcccttcca tgtcgcctct   1020

gcattcagga tcaaaccccg accacctgcc caacctgctc tcctcttgcc actgcctctt   1080

cctccctcat tccaccttcc catgccctgg atccatcagg ccacttgatg acccccaacc   1140

aagtggctcc cacaccctgt tttacaaaaa agaaaagacc agtccatgag ggaggttttt   1200

aagggtttgt ggaaaatgaa aattaggatt tcatgatttt tttttttcag tccccgtgaa   1260

ggagagccct tcatttggag attatgttct ttcggggaga ggctgaggac ttaaaatatt   1320

cctgcatttg tgaaatgatg gtgaaagtaa gtggtagctt ttcccttctt tttcttcttt   1380

ttttgtgatg tcccaacttg taaaaattaa aagttatggt actatgttag ccccataatt   1440

ttttttttcc ttttaaaaca cttccataat ctggactcct ctgtccaggc actgctgccc   1500

agcctccaag ctccatctcc actccagatt ttttacagct gcctgcagta ctttacctcc   1560

tatcagaagt ttctcagctc ccaaggctct gagcaaatgt ggctcctggg ggttctttct   1620

tcctctgctg aaggaataaa ttgctccttg acattgtaga gcttctggca cttggagact   1680

tgtatgaaag atggctgtgc ctctgcctgt ctcccccacc gggctgggag ctctgcagag   1740

caggaaacat gactcgtata tgtctcaggt ccctgcaggg ccaagcacct agcctcgctc   1800

ttggcaggta ctcagcgaat gaatgctgta tatgttgggt gcaaagttcc ctacttcctg   1860

tgacttcagc tctgttttac aataaaatct tgaaaatgcc tata                    1904


<210>  1471
<211>  143
<212>  PRT
<213>  Homo sapiens

<400>  1471


Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu 
1               5                   10                  15      


Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn 
            20                  25                  30          


Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala Leu Phe 
        35                  40                  45              


Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val Lys Ser Gly 
    50                  55                  60                  


Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp Leu Ser 
65                  70                  75                  80  


Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser 
                85                  90                  95      


Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp Phe Leu 
            100                 105                 110         


Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn Met Pro 
        115                 120                 125             


Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
    130                 135                 140             

<210>  1472
<211>  1054
<212>  DNA
<213>  Homo sapiens

<400>  1472
agacctcaga agacctcctg tcctatgagg ccctccccat ggctttagag acgatctgcc     60

gaccctctgg gagaaaatcc agcaagatgc aagccttcag aatctgggat gttaaccaga    120

agaccttcta tctgaggaac aaccaactag ttgctggata cttgcaagga ccaaatgtca    180

atttagaagg tgagtggttg ccaggaaagc caatgtatgt gggcatcacg tcactttgcc    240

cgtctgtctg cagcagcatg gcctgcctgc acaaacccta ggtgcaatgt cctaatcctt    300

gttgggtctt tgtattcaag tttgaagctg ggagggcctg gctactgaag ggcacatatg    360

agggcagcct gaagagggtg tggagaggta gagtctaggt cagaggtcag tgcctatagg    420

cacagtggtc ccagggccac agctgggaag ggcaaatacc agaaggcaag gttgaccatt    480

cccttcctca agtgcctatt aaggctccat gttcctatgt tgttcaaacc ctaactcaat    540

cccaaattaa tccaccatgt ataaggttga gctatgtctc ttattcctgg acaccatact    600

cagccatatt ctggtccaca cattaaacaa gctggatgac cttgaagaag cttcacccac    660

tctgttcctc agctttccct tcagtgggat gatatcaact ggacaacagg atgtgcgatt    720

cttttagttc cagccttcca ggatgttttc actcccctgt ttgttgttgt aggatggtat    780

tacctccacc ttcccacctt ccctatgccc tggttctgtc tcctgtgcct cgctctgaaa    840

gtggatgaga cctacaattc ctgtcctggt agttctccta atgaacacac tgaagcacga    900

ggaagctgag atttttgttg ctacatgaga gcatggaggc ctcttaggga gagaggaggt    960

tcagagactc ctaggctcct gtggagcccc actcatggcc ttgttcattt tccctgcccc   1020

tcagcaacac tcctattgac ctggagcaca ggta                               1054


<210>  1473
<211>  80
<212>  PRT
<213>  Homo sapiens

<400>  1473


Met Ala Leu Glu Thr Ile Cys Arg Pro Ser Gly Arg Lys Ser Ser Lys 
1               5                   10                  15      


Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu 
            20                  25                  30          


Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn 
        35                  40                  45              


Leu Glu Gly Glu Trp Leu Pro Gly Lys Pro Met Tyr Val Gly Ile Thr 
    50                  55                  60                  


Ser Leu Cys Pro Ser Val Cys Ser Ser Met Ala Cys Leu His Lys Pro 
65                  70                  75                  80  

<210>  1474
<211>  1745
<212>  DNA
<213>  Homo sapiens

<400>  1474
atttctttat aaaccacaac tctgggcccg caatggcagt ccactgcctt gctgcagtca     60

cagaatggaa atctgcagag gcctccgcag tcacctaatc actctcctcc tcttcctgtt    120

ccattcagag acgatctgcc gaccctctgg gagaaaatcc agcaagatgc aagccttcag    180

aatctgggat gttaaccaga agaccttcta tctgaggaac aaccaactag ttgctggata    240

cttgcaagga ccaaatgtca atttagaaga aaagatagat gtggtaccca ttgagcctca    300

tgctctgttc ttgggaatcc atggagggaa gatgtgcctg tcctgtgtca agtctggtga    360

tgagaccaga ctccagctgg aggcagttaa catcactgac ctgagcgaga acagaaagca    420

ggacaagcgc ttcgccttca tccgctcaga cagtggcccc accaccagtt ttgagtctgc    480

cgcctgcccc ggttggttcc tctgcacagc gatggaagct gaccagcccg tcagcctcac    540

caatatgcct gacgaaggcg tcatggtcac caaattctac ttccaggagg acgagtagta    600

ctgcccaggc ctgcctgttc ccattcttgc atggcaagga ctgcagggac tgccagtccc    660

cctgccccag ggctcccggc tatgggggca ctgaggacca gccattgagg ggtggaccct    720

cagaaggcgt cacaacaacc tggtcacagg actctgcctc ctcttcaact gaccagcctc    780

catgctgcct ccagaatggt ctttctaatg tgtgaatcag agcacagcag cccctgcaca    840

aagcccttcc atgtcgcctc tgcattcagg atcaaacccc gaccacctgc ccaacctgct    900

ctcctcttgc cactgcctct tcctccctca ttccaccttc ccatgccctg gatccatcag    960

gccacttgat gacccccaac caagtggctc ccacaccctg ttttacaaaa aagaaaagac   1020

cagtccatga gggaggtttt taagggtttg tggaaaatga aaattaggat ttcatgattt   1080

ttttttttca gtccccgtga aggagagccc ttcatttgga gattatgttc tttcggggag   1140

aggctgagga cttaaaatat tcctgcattt gtgaaatgat ggtgaaagta agtggtagct   1200

tttcccttct ttttcttctt tttttgtgat gtcccaactt gtaaaaatta aaagttatgg   1260

tactatgtta gccccataat tttttttttc cttttaaaac acttccataa tctggactcc   1320

tctgtccagg cactgctgcc cagcctccaa gctccatctc cactccagat tttttacagc   1380

tgcctgcagt actttacctc ctatcagaag tttctcagct cccaaggctc tgagcaaatg   1440

tggctcctgg gggttctttc ttcctctgct gaaggaataa attgctcctt gacattgtag   1500

agcttctggc acttggagac ttgtatgaaa gatggctgtg cctctgcctg tctcccccac   1560

cgggctggga gctctgcaga gcaggaaaca tgactcgtat atgtctcagg tccctgcagg   1620

gccaagcacc tagcctcgct cttggcaggt actcagcgaa tgaatgctgt atatgttggg   1680

tgcaaagttc cctacttcct gtgacttcag ctctgtttta caataaaatc ttgaaaatgc   1740

ctata                                                               1745


<210>  1475
<211>  177
<212>  PRT
<213>  Homo sapiens

<400>  1475


Met Glu Ile Cys Arg Gly Leu Arg Ser His Leu Ile Thr Leu Leu Leu 
1               5                   10                  15      


Phe Leu Phe His Ser Glu Thr Ile Cys Arg Pro Ser Gly Arg Lys Ser 
            20                  25                  30          


Ser Lys Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe 
        35                  40                  45              


Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn 
    50                  55                  60                  


Val Asn Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala 
65                  70                  75                  80  


Leu Phe Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val Lys 
                85                  90                  95      


Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp 
            100                 105                 110         


Leu Ser Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser 
        115                 120                 125             


Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp 
    130                 135                 140                 


Phe Leu Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn 
145                 150                 155                 160 


Met Pro Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp 
                165                 170                 175     


Glu 
    

<210>  1476
<211>  1119
<212>  DNA
<213>  Homo sapiens

<400>  1476
acaactctgg gcccgcaatg gcagtccact gccttgctgc agtcacagaa tggaaatctg     60

cagaggcctc cgcagtcacc taatcactct cctcctcttc ctgttccatt cagagacgat    120

ctgccgaccc tctgggagaa aatccagcaa gatgcaagcc ttcagaatct gggatgttaa    180

ccagaagacc ttctatctga ggaacaacca actagttgct ggatacttgc aaggaccaaa    240

tgtcaattta gaaggtgagt ggttgccagg aaagccaatg tatgtgggca tcacgtcact    300

ttgcccgtct gtctgcagca gcatggcctg cctgcacaaa ccctaggtgc aatgtcctaa    360

tccttgttgg gtctttgtat tcaagtttga agctgggagg gcctggctac tgaagggcac    420

atatgagggc agcctgaaga gggtgtggag aggtagagtc taggtcagag gtcagtgcct    480

ataggcacag tggtcccagg gccacagctg ggaagggcaa ataccagaag gcaaggttga    540

ccattccctt cctcaagtgc ctattaaggc tccatgttcc tatgttgttc aaaccctaac    600

tcaatcccaa attaatccac catgtataag gttgagctat gtctcttatt cctggacacc    660

atactcagcc atattctggt ccacacatta aacaagctgg atgaccttga agaagcttca    720

cccactctgt tcctcagctt tcccttcagt gggatgatat caactggaca acaggatgtg    780

cgattctttt agttccagcc ttccaggatg ttttcactcc cctgtttgtt gttgtaggat    840

ggtattacct ccaccttccc accttcccta tgccctggtt ctgtctcctg tgcctcgctc    900

tgaaagtgga tgagacctac aattcctgtc ctggtagttc tcctaatgaa cacactgaag    960

cacgaggaag ctgagatttt tgttgctaca tgagagcatg gaggcctctt agggagagag   1020

gaggttcaga gactcctagg ctcctgtgga gccccactca tggccttgtt cattttccct   1080

gcccctcagc aacactccta ttgacctgga gcacaggta                          1119


<210>  1477
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  1477


Met Glu Ile Cys Arg Gly Leu Arg Ser His Leu Ile Thr Leu Leu Leu 
1               5                   10                  15      


Phe Leu Phe His Ser Glu Thr Ile Cys Arg Pro Ser Gly Arg Lys Ser 
            20                  25                  30          


Ser Lys Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe 
        35                  40                  45              


Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn 
    50                  55                  60                  


Val Asn Leu Glu Gly Glu Trp Leu Pro Gly Lys Pro Met Tyr Val Gly 
65                  70                  75                  80  


Ile Thr Ser Leu Cys Pro Ser Val Cys Ser Ser Met Ala Cys Leu His 
                85                  90                  95      


Lys Pro 
        

<210>  1478
<211>  976
<212>  DNA
<213>  Homo sapiens

<400>  1478
caatggcagt ccactgcctt gctgcagtca cagaatggaa atctgcagag gcctccgcag     60

tcacctaatc actctcctcc tcttcctgtt ccattcagag acgatctgcc gaccctctgg    120

gagaaaatcc agcaagatgc aagccttcag aatctgggat gttaaccaga agaccttcta    180

tctgaggaac aaccaactag ttgctggata cttgcaagga ccaaatgtca atttagaaga    240

aaagatagat gtggtaccca ttgagcctca tgctctgttc ttgggaatcc atggagggaa    300

gatgtgcctg tcctgtgtca agtctggtga tgagaccaga ctccagctgg aggcagttaa    360

catcactgac ctgagcgaga acagaaagca ggacaagcgc ttcgccttca tccgctcaga    420

cagtggcccc accaccagtt ttgagtctgc cgcctgcccc ggttggttcc tctgcacagc    480

gatggaagct gaccagcccg tcagcctcac caatatgcct gacgaaggcg tcatggtcac    540

caaattctac ttccaggagg acgagtagta ctgcccaggc ctgcctgttc ccattcttgc    600

atggcaagga ctgcagggac tgccagtccc cctgccccag ggctcccggc tatgggggca    660

ctgaggacca gccattgagg ggtggaccct cagaaggcgt cacaacaacc tggtcacagg    720

actctgcctc ctcttcaact gaccagcctc catgctgcct ccagaatggt ctttctaatg    780

tgtgaatcag agcacagcag cccctgcaca aagcccttcc atgtcgcctc tgcattcagg    840

atcaaacccc gaccacctgc ccaacctgct ctcctcttgc cactgcctct tcctccctca    900

ttccaccttc ccatgccctg gatccatcag gccacttgat gacccccaac caagtggctc    960

ccacaccctg ttttac                                                    976


<210>  1479
<211>  177
<212>  PRT
<213>  Homo sapiens

<400>  1479


Met Glu Ile Cys Arg Gly Leu Arg Ser His Leu Ile Thr Leu Leu Leu 
1               5                   10                  15      


Phe Leu Phe His Ser Glu Thr Ile Cys Arg Pro Ser Gly Arg Lys Ser 
            20                  25                  30          


Ser Lys Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe 
        35                  40                  45              


Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn 
    50                  55                  60                  


Val Asn Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala 
65                  70                  75                  80  


Leu Phe Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val Lys 
                85                  90                  95      


Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp 
            100                 105                 110         


Leu Ser Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser 
        115                 120                 125             


Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp 
    130                 135                 140                 


Phe Leu Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn 
145                 150                 155                 160 


Met Pro Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp 
                165                 170                 175     


Glu 
    

<210>  1480
<211>  1825
<212>  DNA
<213>  Homo sapiens

<400>  1480
tgtgcatcct ggggaaagtg agggaaatat ggacatcaca tggaacaaca tccaggagac     60

tcaggcctct aggagtaact gggtagtgtg catcctgggg aaagtgaggg aaatatggac    120

atcacatgga acaacatcca ggagactcag gcctctagga gtaactgggt agtgtgcttg    180

gtttaatctt ctatttacct gcagaccagg aagatgagac ctctctgccc ttctgacctc    240

gggattttag ttttgtgggg accaggggag atagaaaaat acccggggtc tcttcattat    300

tgctgcttcc tcttctatta acctgaccct cccctctgtt cttccccaga aaagatagat    360

gtggtaccca ttgagcctca tgctctgttc ttgggaatcc atggagggaa gatgtgcctg    420

tcctgtgtca agtctggtga tgagaccaga ctccagctgg aggcagttaa catcactgac    480

ctgagcgaga acagaaagca ggacaagcgc ttcgccttca tccgctcaga cagtggcccc    540

accaccagtt ttgagtctgc cgcctgcccc ggttggttcc tctgcacagc gatggaagct    600

gaccagcccg tcagcctcac caatatgcct gacgaaggcg tcatggtcac caaattctac    660

ttccaggagg acgagtagta ctgcccaggc ctgcctgttc ccattcttgc atggcaagga    720

ctgcagggac tgccagtccc cctgccccag ggctcccggc tatgggggca ctgaggacca    780

gccattgagg ggtggaccct cagaaggcgt cacaacaacc tggtcacagg actctgcctc    840

ctcttcaact gaccagcctc catgctgcct ccagaatggt ctttctaatg tgtgaatcag    900

agcacagcag cccctgcaca aagcccttcc atgtcgcctc tgcattcagg atcaaacccc    960

gaccacctgc ccaacctgct ctcctcttgc cactgcctct tcctccctca ttccaccttc   1020

ccatgccctg gatccatcag gccacttgat gacccccaac caagtggctc ccacaccctg   1080

ttttacaaaa aagaaaagac cagtccatga gggaggtttt taagggtttg tggaaaatga   1140

aaattaggat ttcatgattt ttttttttca gtccccgtga aggagagccc ttcatttgga   1200

gattatgttc tttcggggag aggctgagga cttaaaatat tcctgcattt gtgaaatgat   1260

ggtgaaagta agtggtagct tttcccttct ttttcttctt tttttgtgat gtcccaactt   1320

gtaaaaatta aaagttatgg tactatgtta gccccataat tttttttttc cttttaaaac   1380

acttccataa tctggactcc tctgtccagg cactgctgcc cagcctccaa gctccatctc   1440

cactccagat tttttacagc tgcctgcagt actttacctc ctatcagaag tttctcagct   1500

cccaaggctc tgagcaaatg tggctcctgg gggttctttc ttcctctgct gaaggaataa   1560

attgctcctt gacattgtag agcttctggc acttggagac ttgtatgaaa gatggctgtg   1620

cctctgcctg tctcccccac cgggctggga gctctgcaga gcaggaaaca tgactcgtat   1680

atgtctcagg tccctgcagg gccaagcacc tagcctcgct cttggcaggt actcagcgaa   1740

tgaatgctgt atatgttggg tgcaaagttc cctacttcct gtgacttcag ctctgtttta   1800

caataaaatc ttgaaaatgc ctata                                         1825


<210>  1481
<211>  88
<212>  PRT
<213>  Homo sapiens

<400>  1481


Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu 
1               5                   10                  15      


Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys 
            20                  25                  30          


Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu 
        35                  40                  45              


Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp 
    50                  55                  60                  


Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr 
65                  70                  75                  80  


Lys Phe Tyr Phe Gln Glu Asp Glu 
                85              

<210>  1482
<211>  1033
<212>  DNA
<213>  Homo sapiens

<400>  1482
cgtcatggtc accaaattct acttccagga ggacgagtag tactgcccag gcctgcctgt     60

tcccattctt gcatggcaag gactgcaggg actgccagtc cccctgcccc agggctcccg    120

gctatggggg cactgaggac cagccattga ggggtggacc ctcagaaggc gtcacaacaa    180

cctggtcaca ggactctgcc tcctcttcaa ctgaccagcc tccatgctgc ctccagaatg    240

gtctttctaa tgtgtgaatc agagcacagc agcccctgca caaagccctt ccatgtcgcc    300

tctgcattca ggatcaaacc ccgaccacct gcccaacctg ctctcctctt gccactgcct    360

cttcctccct cattccacct tcccatgccc tggatccatc aggccacttg atgaccccca    420

accaagtggc tcccacaccc tgttttacaa aaaagaaaag accagtccat gagggaggtt    480

tttaagggtt tgtggaaaat gaaaattagg atttcatgat tttttttttt cagtccccgt    540

gaaggagagc ccttcatttg gagattatgt tctttcgggg agaggctgag gacttaaaat    600

attcctgcat ttgtgaaatg atggtgaaag taagtggtag cttttccctt ctttttcttc    660

tttttttgtg atgtcccaac ttgtaaaaat taaaagttat ggtactatgt tagccccata    720

attttttttt tccttttaaa acacttccat aatctggact cctctgtcca ggcactgctg    780

cccagcctcc aagctccatc tccactccag attttttaca gctgcctgca gtactttacc    840

tcctatcaga agtttctcag ctcccaaggc tctgagcaaa tgtggctcct gggggttctt    900

tcttcctctg ctgaaggaat aaattgctcc ttgacattgt agagcttctg gcacttggag    960

acttgtatga aagaatgttg ggtgcaaagt tccctacttc ctgtgacttc agctctgttt   1020

tacaataaaa tct                                                      1033


<210>  1483
<211>  59
<212>  PRT
<213>  Homo sapiens

<400>  1483


Met Ser Pro Leu His Ser Gly Ser Asn Pro Asp His Leu Pro Asn Leu 
1               5                   10                  15      


Leu Ser Ser Cys His Cys Leu Phe Leu Pro His Ser Thr Phe Pro Cys 
            20                  25                  30          


Pro Gly Ser Ile Arg Pro Leu Asp Asp Pro Gln Pro Ser Gly Ser His 
        35                  40                  45              


Thr Leu Phe Tyr Lys Lys Glu Lys Thr Ser Pro 
    50                  55                  

<210>  1484
<211>  577
<212>  DNA
<213>  Homo sapiens

<400>  1484
agtgctactg aaggcctgtg gtgaggccag cagaggctca ggaagggagc agaggatggc     60

ggtctgaggt tttacaactc tctctctcca tcaagctggg taagtcagaa acctgaagtc    120

accaagacct aaatgcaaac cctccactct gggccccagc cgctaggggt gtctccggaa    180

catggccaag gctcaaagtc agcacctgct ctgtgcaggc tctatgctac aagccgctga    240

cctatcagga ataaaacaca tgacccctgt ggaagctgaa gcaactccat cttggaagct    300

aacctgccac attgacttaa ctgagtgacc ccagttccaa ggcagggcct ctacaatttc    360

cagtttatct attgtttcct gtgtaagagc agatacttac tgtaagtccg taagtgctac    420

tcgtaggtca aacaaccttg atgatatcac acttcaattg tcttataaat cccatctgaa    480

ccactcctac cctatggtat atgagccctg ggtttgggtg ctaatgcggg gatccaccat    540

ctcatctcat tgccgcctga gacacctaca tggcttc                             577


<210>  1485
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  1485


Met Ala Lys Ala Gln Ser Gln His Leu Leu Cys Ala Gly Ser Met Leu 
1               5                   10                  15      


Gln Ala Ala Asp Leu Ser Gly Ile Lys His Met Thr Pro Val Glu Ala 
            20                  25                  30          


Glu Ala Thr Pro Ser Trp Lys Leu Thr Cys His Ile Asp Leu Thr Glu 
        35                  40                  45              

<210>  1486
<211>  583
<212>  DNA
<213>  Homo sapiens

<400>  1486
agagagagag agagagagaa gacagtgcta ctgaaggcct gtggtgaggc cagcagaggc     60

tcaggaaggg agcagaggat ggcggtctga ggttccacca gccccaacct aggcagaccc    120

acttagctca cctccaaagg acccaagaat ggatggcttg gcctgggctc cccaagagca    180

cttcctggct cacagtcggc ttgcccagtg aatgtggctg tgacggctgg agcttccgac    240

ttccgctcct cctcaccaca acacacaccc ctcctgctcc ccgccgcctc cccagggttc    300

cctagctgct caacacctca cacttcctgc ccacaagata agagcctctc ttcctaggcc    360

cagcgcctgc agcccctttc cccatgcccc tgctccttgg aggcccccac cctgcacacc    420

agcctagaaa gaacctgcca tggtggaact ggcctctccc tgccatgcag gggcctggga    480

ttgaaagggg aaggggccga ggcctggttg gtaagcaggc cccacctcct tcctccctgc    540

gcttctgccc caggttctca gtcttgctct ggctcttggt ccc                      583


<210>  1487
<211>  65
<212>  PRT
<213>  Homo sapiens

<400>  1487


Met Pro Leu Leu Leu Gly Gly Pro His Pro Ala His Gln Pro Arg Lys 
1               5                   10                  15      


Asn Leu Pro Trp Trp Asn Trp Pro Leu Pro Ala Met Gln Gly Pro Gly 
            20                  25                  30          


Ile Glu Arg Gly Arg Gly Arg Gly Leu Val Gly Lys Gln Ala Pro Pro 
        35                  40                  45              


Pro Ser Ser Leu Arg Phe Cys Pro Arg Phe Ser Val Leu Leu Trp Leu 
    50                  55                  60                  


Leu 
65  

<210>  1488
<211>  4628
<212>  DNA
<213>  Homo sapiens

<400>  1488
acattcactg ggcaagccga ctgtgagcca ggaagtgctc ttggggagcc caggccaagc     60

catccattct tgggtccttt ggagggtaga tatggattcc cagtttctcc agcggccagt    120

gctcccccta gtccacacag tgagaccgtg aaagcagatg ctccggggca ctcctgggca    180

gcttttgctc agtggatgat gggtgactac agactccctg accaccccca gcccatggaa    240

attctcaacc tgtacttggg agacagcctg gagccccacc caggagagtg cccaagggaa    300

acgtgcagcc atgaggatcc accggagcct ttcgaggagc aaacctgggc cactgaccct    360

cctgaaccta ccagacaaaa tgttcctccc tggggctccg gtgtggagct cacacacctg    420

gggagctggg tccatcagga cgggctggag ccttgccagg agcaaacccg ggccactgac    480

cctcctgaat ctaccagaca agatgctcct ccctggggct ccggtgtgga gctcacacac    540

ctggggagcc cctctgccca gagggagcac aggcagaaca cagcatcacc agggtcacca    600

gtgaacagcc atctaccggg gagcccaaag cagaaccgga gcacgtccac acaggtagtg    660

ttctgggcag gcatcctgca ggcccagatg tgtgtcctag acctggagga ggagctggag    720

aagacggaag ggctcaaggc tgggctgaaa tgctgtctcc ccacgccccc tgtggacctc    780

cccggggaca cgggcctgca ctccagccca cctgagaatg aagactcagg ggaagacagc    840

agtgagcctg agggagaggg ccaggcatgg ctgagagagg gaaccccaga ctcttcccca    900

cagtggggag ctgaggagga gagcatgttc ttcagcaacc ccctcttcct ggcgagtcct    960

tgctcagaga acagtgcttc tggagagtgc ttttcctggg gggcttcaga ctcccatgca   1020

ggtgtgagga ctggacctga gagcccagcg actctggagc ctcccctccc agaagacaca   1080

gtgctgtggg agctggaaag tgagccagat ttgggggacg gcgctgctat cagtgggcat   1140

tgtacccctc cattccctgt gcccatctat aaaccacact ccatctgctg ggcctcagtg   1200

gctgccgctg agggggctcc tgcagcacct cctggtcacg gggagagtga gggagatagg   1260

cttggtcctg ctccatctgc agcaccgggc ctctctcagc cctgagggct ggcagagagg   1320

aggtcctttt tggccccagg tgactcttaa ctcccaggac agagagccta gcagcccaga   1380

atctgagagc agaggccctg gtcccaggcc cagccctgca tcgtcccagg agggcagccc   1440

gcagcttcaa caccacagct caggcatttt gcccaagtgg acactagatg cttcacagtc   1500

ttcactcttg gagacggatg gggaacagcc aagttccttg aagaaaaagg aggcagggga   1560

ggccccaaaa ccaggcgagg aagtaaagag tgaaggaaca gccaggcctg cagagactgg   1620

agacgtccag cctgacattc acctgacttc tgcagaacat gagaatctga ggacaccgat   1680

gaactcttct tggcttcctg ggagccctat gccccaagca cagtccccag aggaaggcca   1740

gagaccacca gctggagaca agctagctaa tggcgtcagg aacaacaagg tagcctggaa   1800

cttggcctca cgcctctatc gcctggaggg cttccggaag tctgaagtgg ctgcctacct   1860

gcagaagaac aatgacttta gcagggctgt ggctgaggag tacctgtcct tcttccagtt   1920

tggaggccag agtctggacc gagccctccg gagcttcctc caggccttgg tgctcagtgg   1980

ggagactcag gaacgggagc gaatcctcta ccagttctcc agacgcttcc accattgcaa   2040

tccggggatc ttcccctcag tagattctgt acacaccttg acatgtgcaa tcatgctgct   2100

taacacggac ctgcatggac agaacattgg gaagagcatg agctgccagg aattcataac   2160

caacctgaat gggctgaggg atggcgggaa cttccccaag gagctgctga aggccctcta   2220

ctggtctatc cgcagcgaga agctcgagtg ggccgtggat gaagaagaca cagccagacc   2280

tgagaaggcc cagccgtccc tgccagctgg caagatgagc aagcccttcc ttcagctggc   2340

tcaggatccc acagtgccca cctacaagca gggcatcctg gctcggaaaa tgcatcaaga   2400

tgcagacggc aagaagacgc catggggcaa gcgtggctgg aagatgttcc acaccttact   2460

gcgagggatg gttctctact tcctgaagca gggagaagac cactgtctgg agggggagag   2520

cttggtgggg cagatggtgg atgagcccgt gggggtgcac cactcgctgg ccacccccgc   2580

cacgcattac accaagaagc cgcacgtctt ccagctgcgc acggctgact ggcgcctcta   2640

cctcttccag gcacccactg ccaaggagat gagctcctgg atcgcgcgca tcaacttggc   2700

tgcggccacg cactccgcgc cgcccttccc cgccgctgtg ggctcccagc gcagattcgt   2760

gcggcccatc ctgcccgtgg gccccgccca gagctccctg gaggagcagc atcgatccca   2820

cgagaactgc ctggacgctg ccgcggacga cctgctggat ctacagagga acctgccgga   2880

gcggcggggc cgtggccgcg agctggagga gcaccgcctg cggaaggagt acctggagta   2940

cgagaaaacc cgctacgaga cctacgtgca gctgctggtg gcccgcctgc actgcccctc   3000

tgatgctctg gacctgtggg aggagcagct ggggagggaa gctggaggca ctcgggagcc   3060

caagctcagc ctgaagaagt cccactcgag cccgtccctg caccaggatg aggctcccac   3120

cacggccaag gtgaagcgca acatctcaga gcgcagaacc taccggaaga tcatccctaa   3180

gcggaaccgc aatcagctgt gaagccagca ccacctcaga gacactgttc cctgctccag   3240

ggtagacctg agatgaacct ccctggagga gacttatttc aatgagtcca ccatgacgga   3300

tgaggcacct cctttccctg ctgaaggaca aaccttgttt ccctgtggcc ctcattcttg   3360

tgctccctga agctttccta atattgctgt gctccccacc acccccatgg cagtccctcc   3420

gcagccccag tccctggcca cgcccaaggg aagagggagg tgaggacttg actttcctcc   3480

cagagctcag cccatgtcac cctccaggcc ccagaatcca gagtggcctc atttcctaga   3540

cttgctgaga actcagcact tgtttgagaa ccagtgctta tgtggtgtgc ccttggcttc   3600

tgggggagag cttggggcag cagaggcccc tgggcagccc agccagggga gccacagccc   3660

caaggatggt cttgctctgg gaattaggtg accttcctgg ggaggcccca ggagagtgaa   3720

tcagggactc ttgagaaatt cctaaccagc ctcctgtgac ccagggagca gggtcgctaa   3780

ggtcctgccc actgagggga cagccttctg ggcagggacc tcggggggct tcaagggctc   3840

tgcacggctg tggggccctg tgcctttgtc tccttgtgtc tcctttcccc cgaagtagat   3900

gaaacagtct cacataccca actgctcatc aacagagcag agctgatggc atgagtgagg   3960

gctgggcggg gtggggcctc cagagctttg cagggaaccc tggaacccta ggaacaagga   4020

gcctttgttc caacagagca gagaaggagg ttctctatgt tcagaccact ggagaggata   4080

gagaggtaaa aggtggcgac agtttccctt aggggtctgc ctggcaggag ccacagctca   4140

ggagagttgt gagggatggg acggaggctg gcgaccaggc gaggcctagg ccaggctcgg   4200

gagacttttc tgtgctcctt tctacacatg ccttaaacct tccttcctgt ggggtgcctg   4260

gaccccttcc ccatctctgg cagctcagag ggtctctgct gctctcccct gggaaatccc   4320

ctcatcctgc cctctggctg cctcccagct gggcttgttc tctgagggag gttccggaga   4380

ctcatggact tggggctctg cctgtaggaa ggaggctggg ccggagggac cagccaccat   4440

tgtctctgtt cagccaagtg tgcaagtagg ctgcccgcca agagggggcc tctgctaccc   4500

gctgctgcct gccggctgac acactgcctc cccagccttc ctgctaggcc accctcctcc   4560

cttcccatgc ttgtaaccag ctctggggct tgcacctcca caaagtaagg ttggcccttg   4620

gaggccat                                                            4628


<210>  1489
<211>  507
<212>  PRT
<213>  Homo sapiens

<400>  1489


Met Asn Ser Ser Trp Leu Pro Gly Ser Pro Met Pro Gln Ala Gln Ser 
1               5                   10                  15      


Pro Glu Glu Gly Gln Arg Pro Pro Ala Gly Asp Lys Leu Ala Asn Gly 
            20                  25                  30          


Val Arg Asn Asn Lys Val Ala Trp Asn Leu Ala Ser Arg Leu Tyr Arg 
        35                  40                  45              


Leu Glu Gly Phe Arg Lys Ser Glu Val Ala Ala Tyr Leu Gln Lys Asn 
    50                  55                  60                  


Asn Asp Phe Ser Arg Ala Val Ala Glu Glu Tyr Leu Ser Phe Phe Gln 
65                  70                  75                  80  


Phe Gly Gly Gln Ser Leu Asp Arg Ala Leu Arg Ser Phe Leu Gln Ala 
                85                  90                  95      


Leu Val Leu Ser Gly Glu Thr Gln Glu Arg Glu Arg Ile Leu Tyr Gln 
            100                 105                 110         


Phe Ser Arg Arg Phe His His Cys Asn Pro Gly Ile Phe Pro Ser Val 
        115                 120                 125             


Asp Ser Val His Thr Leu Thr Cys Ala Ile Met Leu Leu Asn Thr Asp 
    130                 135                 140                 


Leu His Gly Gln Asn Ile Gly Lys Ser Met Ser Cys Gln Glu Phe Ile 
145                 150                 155                 160 


Thr Asn Leu Asn Gly Leu Arg Asp Gly Gly Asn Phe Pro Lys Glu Leu 
                165                 170                 175     


Leu Lys Ala Leu Tyr Trp Ser Ile Arg Ser Glu Lys Leu Glu Trp Ala 
            180                 185                 190         


Val Asp Glu Glu Asp Thr Ala Arg Pro Glu Lys Ala Gln Pro Ser Leu 
        195                 200                 205             


Pro Ala Gly Lys Met Ser Lys Pro Phe Leu Gln Leu Ala Gln Asp Pro 
    210                 215                 220                 


Thr Val Pro Thr Tyr Lys Gln Gly Ile Leu Ala Arg Lys Met His Gln 
225                 230                 235                 240 


Asp Ala Asp Gly Lys Lys Thr Pro Trp Gly Lys Arg Gly Trp Lys Met 
                245                 250                 255     


Phe His Thr Leu Leu Arg Gly Met Val Leu Tyr Phe Leu Lys Gln Gly 
            260                 265                 270         


Glu Asp His Cys Leu Glu Gly Glu Ser Leu Val Gly Gln Met Val Asp 
        275                 280                 285             


Glu Pro Val Gly Val His His Ser Leu Ala Thr Pro Ala Thr His Tyr 
    290                 295                 300                 


Thr Lys Lys Pro His Val Phe Gln Leu Arg Thr Ala Asp Trp Arg Leu 
305                 310                 315                 320 


Tyr Leu Phe Gln Ala Pro Thr Ala Lys Glu Met Ser Ser Trp Ile Ala 
                325                 330                 335     


Arg Ile Asn Leu Ala Ala Ala Thr His Ser Ala Pro Pro Phe Pro Ala 
            340                 345                 350         


Ala Val Gly Ser Gln Arg Arg Phe Val Arg Pro Ile Leu Pro Val Gly 
        355                 360                 365             


Pro Ala Gln Ser Ser Leu Glu Glu Gln His Arg Ser His Glu Asn Cys 
    370                 375                 380                 


Leu Asp Ala Ala Ala Asp Asp Leu Leu Asp Leu Gln Arg Asn Leu Pro 
385                 390                 395                 400 


Glu Arg Arg Gly Arg Gly Arg Glu Leu Glu Glu His Arg Leu Arg Lys 
                405                 410                 415     


Glu Tyr Leu Glu Tyr Glu Lys Thr Arg Tyr Glu Thr Tyr Val Gln Leu 
            420                 425                 430         


Leu Val Ala Arg Leu His Cys Pro Ser Asp Ala Leu Asp Leu Trp Glu 
        435                 440                 445             


Glu Gln Leu Gly Arg Glu Ala Gly Gly Thr Arg Glu Pro Lys Leu Ser 
    450                 455                 460                 


Leu Lys Lys Ser His Ser Ser Pro Ser Leu His Gln Asp Glu Ala Pro 
465                 470                 475                 480 


Thr Thr Ala Lys Val Lys Arg Asn Ile Ser Glu Arg Arg Thr Tyr Arg 
                485                 490                 495     


Lys Ile Ile Pro Lys Arg Asn Arg Asn Gln Leu 
            500                 505         

<210>  1490
<211>  4712
<212>  DNA
<213>  Homo sapiens

<400>  1490
acattcactg ggcaagccga ctgtgagcca ggaagtgctc ttggggagcc caggccaagc     60

catccattct tgggtccttt ggagggtaga tatggattcc cagtttctcc agcggccagt    120

gctcccccta gtccacacag tgagaccgtg aaagcagatg ctccggggca ctcctgggca    180

gcttttgctc agtggatgat gggtgactac agactccctg accaccccca gcccatggaa    240

attctcaacc tgtacttggg agacagcctg gagccccacc caggagagtg cccaagggaa    300

acgtgcagcc atgaggatcc accggagcct ttcgaggagc aaacctgggc cactgaccct    360

cctgaaccta ccagacaaaa tgttcctccc tggggctccg gtgtggagct cacacacctg    420

gggagctggg tccatcagga cgggctggag ccttgccagg agcaaacccg ggccactgac    480

cctcctgaat ctaccagaca agatgctcct ccctggggct ccggtgtgga gctcacacac    540

ctggggagcc cctctgccca gagggagcac aggcagaaca cagcatcacc agggtcacca    600

gtgaacagcc atctaccggg gagcccaaag cagaaccgga gcacgtccac acaggtagtg    660

ttctgggcag gcatcctgca ggcccagatg tgtgtcctag acctggagga ggagctggag    720

aagacggaag ggctcaaggc tgggctgaaa tgctgtctcc ccacgccccc tgtggacctc    780

cccggggaca cgggcctgca ctccagccca cctgagaatg aagactcagg ggaagacagc    840

agtgagcctg agggagaggg ccaggcatgg ctgagagagg gaaccccaga ctcttcccca    900

cagtggggag ctgaggagga gagcatgttc ttcagcaacc ccctcttcct ggcgagtcct    960

tgctcagaga acagtgcttc tggagagtgc ttttcctggg gggcttcaga ctcccatgca   1020

ggtgtgagga ctggacctga gagcccagcg actctggagc ctcccctccc agaagacaca   1080

gtgctgtggg agctggaaag tgagccagat ttgggggacg gcgctgctat cagtgggcat   1140

tgtacccctc cattccctgt gcccatctat aaaccacact ccatctgctg ggcctcagtg   1200

gctgccgctg agggggctcc tgcagcacct cctggtcacg gggagagtga gggagatagg   1260

cttggtcctg ctccatctgc agcaccgggc ctctctcagc cctgagggct ggcagagagg   1320

aggtcctttt tggccccagg tgactcttaa ctcccaggac agagatgaga gggagggtgg   1380

acacccccag gaatctcttc cctgcacctt ggccccctgc ccctggagga gcccagcttc   1440

ttctccagag cctagcagcc cagaatctga gagcagaggc cctggtccca ggcccagccc   1500

tgcatcgtcc caggagggca gcccgcagct tcaacaccac agctcaggca ttttgcccaa   1560

gtggacacta gatgcttcac agtcttcact cttggagacg gatggggaac agccaagttc   1620

cttgaagaaa aaggaggcag gggaggcccc aaaaccaggc gaggaagtaa agagtgaagg   1680

aacagccagg cctgcagaga ctggagacgt ccagcctgac attcacctga cttctgcaga   1740

acatgagaat ctgaggacac cgatgaactc ttcttggctt cctgggagcc ctatgcccca   1800

agcacagtcc ccagaggaag gccagagacc accagctgga gacaagctag ctaatggcgt   1860

caggaacaac aaggtagcct ggaacttggc ctcacgcctc tatcgcctgg agggcttccg   1920

gaagtctgaa gtggctgcct acctgcagaa gaacaatgac tttagcaggg ctgtggctga   1980

ggagtacctg tccttcttcc agtttggagg ccagagtctg gaccgagccc tccggagctt   2040

cctccaggcc ttggtgctca gtggggagac tcaggaacgg gagcgaatcc tctaccagtt   2100

ctccagacgc ttccaccatt gcaatccggg gatcttcccc tcagtagatt ctgtacacac   2160

cttgacatgt gcaatcatgc tgcttaacac ggacctgcat ggacagaaca ttgggaagag   2220

catgagctgc caggaattca taaccaacct gaatgggctg agggatggcg ggaacttccc   2280

caaggagctg ctgaaggccc tctactggtc tatccgcagc gagaagctcg agtgggccgt   2340

ggatgaagaa gacacagcca gacctgagaa ggcccagccg tccctgccag ctggcaagat   2400

gagcaagccc ttccttcagc tggctcagga tcccacagtg cccacctaca agcagggcat   2460

cctggctcgg aaaatgcatc aagatgcaga cggcaagaag acgccatggg gcaagcgtgg   2520

ctggaagatg ttccacacct tactgcgagg gatggttctc tacttcctga agcagggaga   2580

agaccactgt ctggaggggg agagcttggt ggggcagatg gtggatgagc ccgtgggggt   2640

gcaccactcg ctggccaccc ccgccacgca ttacaccaag aagccgcacg tcttccagct   2700

gcgcacggct gactggcgcc tctacctctt ccaggcaccc actgccaagg agatgagctc   2760

ctggatcgcg cgcatcaact tggctgcggc cacgcactcc gcgccgccct tccccgccgc   2820

tgtgggctcc cagcgcagat tcgtgcggcc catcctgccc gtgggccccg cccagagctc   2880

cctggaggag cagcatcgat cccacgagaa ctgcctggac gctgccgcgg acgacctgct   2940

ggatctacag aggaacctgc cggagcggcg gggccgtggc cgcgagctgg aggagcaccg   3000

cctgcggaag gagtacctgg agtacgagaa aacccgctac gagacctacg tgcagctgct   3060

ggtggcccgc ctgcactgcc cctctgatgc tctggacctg tgggaggagc agctggggag   3120

ggaagctgga ggcactcggg agcccaagct cagcctgaag aagtcccact cgagcccgtc   3180

cctgcaccag gatgaggctc ccaccacggc caaggtgaag cgcaacatct cagagcgcag   3240

aacctaccgg aagatcatcc ctaagcggaa ccgcaatcag ctgtgaagcc agcaccacct   3300

cagagacact gttccctgct ccagggtaga cctgagatga acctccctgg aggagactta   3360

tttcaatgag tccaccatga cggatgaggc acctcctttc cctgctgaag gacaaacctt   3420

gtttccctgt ggccctcatt cttgtgctcc ctgaagcttt cctaatattg ctgtgctccc   3480

caccaccccc atggcagtcc ctccgcagcc ccagtccctg gccacgccca agggaagagg   3540

gaggtgagga cttgactttc ctcccagagc tcagcccatg tcaccctcca ggccccagaa   3600

tccagagtgg cctcatttcc tagacttgct gagaactcag cacttgtttg agaaccagtg   3660

cttatgtggt gtgcccttgg cttctggggg agagcttggg gcagcagagg cccctgggca   3720

gcccagccag gggagccaca gccccaagga tggtcttgct ctgggaatta ggtgaccttc   3780

ctggggaggc cccaggagag tgaatcaggg actcttgaga aattcctaac cagcctcctg   3840

tgacccaggg agcagggtcg ctaaggtcct gcccactgag gggacagcct tctgggcagg   3900

gacctcgggg ggcttcaagg gctctgcacg gctgtggggc cctgtgcctt tgtctccttg   3960

tgtctccttt cccccgaagt agatgaaaca gtctcacata cccaactgct catcaacaga   4020

gcagagctga tggcatgagt gagggctggg cggggtgggg cctccagagc tttgcaggga   4080

accctggaac cctaggaaca aggagccttt gttccaacag agcagagaag gaggttctct   4140

atgttcagac cactggagag gatagagagg taaaaggtgg cgacagtttc ccttaggggt   4200

ctgcctggca ggagccacag ctcaggagag ttgtgaggga tgggacggag gctggcgacc   4260

aggcgaggcc taggccaggc tcgggagact tttctgtgct cctttctaca catgccttaa   4320

accttccttc ctgtggggtg cctggacccc ttccccatct ctggcagctc agagggtctc   4380

tgctgctctc ccctgggaaa tcccctcatc ctgccctctg gctgcctccc agctgggctt   4440

gttctctgag ggaggttccg gagactcatg gacttggggc tctgcctgta ggaaggaggc   4500

tgggccggag ggaccagcca ccattgtctc tgttcagcca agtgtgcaag taggctgccc   4560

gccaagaggg ggcctctgct acccgctgct gcctgccggc tgacacactg cctccccagc   4620

cttcctgcta ggccaccctc ctcccttccc atgcttgtaa ccagctctgg ggcttgcacc   4680

tccacaaagt aaggttggcc cttggaggcc at                                 4712


<210>  1491
<211>  507
<212>  PRT
<213>  Homo sapiens

<400>  1491


Met Asn Ser Ser Trp Leu Pro Gly Ser Pro Met Pro Gln Ala Gln Ser 
1               5                   10                  15      


Pro Glu Glu Gly Gln Arg Pro Pro Ala Gly Asp Lys Leu Ala Asn Gly 
            20                  25                  30          


Val Arg Asn Asn Lys Val Ala Trp Asn Leu Ala Ser Arg Leu Tyr Arg 
        35                  40                  45              


Leu Glu Gly Phe Arg Lys Ser Glu Val Ala Ala Tyr Leu Gln Lys Asn 
    50                  55                  60                  


Asn Asp Phe Ser Arg Ala Val Ala Glu Glu Tyr Leu Ser Phe Phe Gln 
65                  70                  75                  80  


Phe Gly Gly Gln Ser Leu Asp Arg Ala Leu Arg Ser Phe Leu Gln Ala 
                85                  90                  95      


Leu Val Leu Ser Gly Glu Thr Gln Glu Arg Glu Arg Ile Leu Tyr Gln 
            100                 105                 110         


Phe Ser Arg Arg Phe His His Cys Asn Pro Gly Ile Phe Pro Ser Val 
        115                 120                 125             


Asp Ser Val His Thr Leu Thr Cys Ala Ile Met Leu Leu Asn Thr Asp 
    130                 135                 140                 


Leu His Gly Gln Asn Ile Gly Lys Ser Met Ser Cys Gln Glu Phe Ile 
145                 150                 155                 160 


Thr Asn Leu Asn Gly Leu Arg Asp Gly Gly Asn Phe Pro Lys Glu Leu 
                165                 170                 175     


Leu Lys Ala Leu Tyr Trp Ser Ile Arg Ser Glu Lys Leu Glu Trp Ala 
            180                 185                 190         


Val Asp Glu Glu Asp Thr Ala Arg Pro Glu Lys Ala Gln Pro Ser Leu 
        195                 200                 205             


Pro Ala Gly Lys Met Ser Lys Pro Phe Leu Gln Leu Ala Gln Asp Pro 
    210                 215                 220                 


Thr Val Pro Thr Tyr Lys Gln Gly Ile Leu Ala Arg Lys Met His Gln 
225                 230                 235                 240 


Asp Ala Asp Gly Lys Lys Thr Pro Trp Gly Lys Arg Gly Trp Lys Met 
                245                 250                 255     


Phe His Thr Leu Leu Arg Gly Met Val Leu Tyr Phe Leu Lys Gln Gly 
            260                 265                 270         


Glu Asp His Cys Leu Glu Gly Glu Ser Leu Val Gly Gln Met Val Asp 
        275                 280                 285             


Glu Pro Val Gly Val His His Ser Leu Ala Thr Pro Ala Thr His Tyr 
    290                 295                 300                 


Thr Lys Lys Pro His Val Phe Gln Leu Arg Thr Ala Asp Trp Arg Leu 
305                 310                 315                 320 


Tyr Leu Phe Gln Ala Pro Thr Ala Lys Glu Met Ser Ser Trp Ile Ala 
                325                 330                 335     


Arg Ile Asn Leu Ala Ala Ala Thr His Ser Ala Pro Pro Phe Pro Ala 
            340                 345                 350         


Ala Val Gly Ser Gln Arg Arg Phe Val Arg Pro Ile Leu Pro Val Gly 
        355                 360                 365             


Pro Ala Gln Ser Ser Leu Glu Glu Gln His Arg Ser His Glu Asn Cys 
    370                 375                 380                 


Leu Asp Ala Ala Ala Asp Asp Leu Leu Asp Leu Gln Arg Asn Leu Pro 
385                 390                 395                 400 


Glu Arg Arg Gly Arg Gly Arg Glu Leu Glu Glu His Arg Leu Arg Lys 
                405                 410                 415     


Glu Tyr Leu Glu Tyr Glu Lys Thr Arg Tyr Glu Thr Tyr Val Gln Leu 
            420                 425                 430         


Leu Val Ala Arg Leu His Cys Pro Ser Asp Ala Leu Asp Leu Trp Glu 
        435                 440                 445             


Glu Gln Leu Gly Arg Glu Ala Gly Gly Thr Arg Glu Pro Lys Leu Ser 
    450                 455                 460                 


Leu Lys Lys Ser His Ser Ser Pro Ser Leu His Gln Asp Glu Ala Pro 
465                 470                 475                 480 


Thr Thr Ala Lys Val Lys Arg Asn Ile Ser Glu Arg Arg Thr Tyr Arg 
                485                 490                 495     


Lys Ile Ile Pro Lys Arg Asn Arg Asn Gln Leu 
            500                 505         

<210>  1492
<211>  5543
<212>  DNA
<213>  Homo sapiens

<400>  1492
acattcactg ggcaagccga ctgtgagcca ggaagtgctc ttggggagcc caggccaagc     60

catccattct tgggtccttt ggagggtaga tatggattcc cagtttctcc agcggccagt    120

gctcccccta gtccacacag tgagaccgtg aaagcagatg ctccggggca ctcctgggca    180

gcttttgctc agtggatgat gggtgactac agactccctg accaccccca gcccatggaa    240

attctcaacc tgtacttggg agacagcctg gagccccacc caggagagtg cccaagggaa    300

acgtgcagcc atgaggatcc accggagcct ttcgaggagc aaacctgggc cactgaccct    360

cctgaaccta ccagacaaaa tgttcctccc tggggctccg gtgtggagct cacacacctg    420

gggagctggg tccatcagga cgggctggag ccttgccagg agcaaacccg ggccactgac    480

cctcctgaat ctaccagaca agatgctcct ccctggggct ccggtgtgga gctcacacac    540

ctggggagcc cctctgccca gagggagcac aggcagaaca cagcatcacc agggtcacca    600

gtgaacagcc atctaccggg gagcccaaag cagaaccgga gcacgtccac acaggtagtg    660

ttctgggcag gcatcctgca ggcccagatg tgtgtcctag acctggagga ggagctggag    720

aagacggaag ggctcaaggc tgggctgaaa tgctgtctcc ccacgccccc tgtggacctc    780

cccggggaca cgggcctgca ctccagccca cctgagaatg aagactcagg ggaagacagc    840

agtgagcctg agggagaggg ccaggcatgg ctgagagagg gaaccccaga ctcttcccca    900

cagtggggag ctgaggagga gagcatgttc ttcagcaacc ccctcttcct ggcgagtcct    960

tgctcagaga acagtgcttc tggagagtgc ttttcctggg gggcttcaga ctcccatgca   1020

ggtgtgagga ctggacctga gagcccagcg actctggagc ctcccctccc agaagacaca   1080

gtgctgtggg agctggaaag tgagccagat ttgggggacg gcgctgctat cagtgggcat   1140

tgtacccctc cattccctgt gcccatctat aaaccacact ccatctgctg ggcctcagtg   1200

gctgccgctg agggggctcc tgcagcacct cctggtcacg gggagagtga gggagatagg   1260

cttggtcctg ctccatctgc agcaccgggc ctctctcagc cctgagggct ggcagagagg   1320

aggtcctttt tggccccagg tgactcttaa ctcccaggac agaggtgagc cctaataagg   1380

gggtttggga aattgggtcc tgggaggatt tggaatttgg agtggggaca aagatcattc   1440

ttggatccat ggttgccatt aatgggtccc attatattgt gtttaagcca gacagacttg   1500

gggttaaatc ctgcctcttt aaaattaaat gaaggaaacg tacaaaagga ccagcatttc   1560

ttaccgctgg gtcttaatgg tttagcaaag gtcctgagcc cttagttgcc tggaggcttg   1620

agtcctggga gcccgctgtc tgctgcctct gcaagtggga gaggtcactg cccgagggag   1680

gacagggcat gctgccaggc tccaggggag gagccccagg gagggagcct ctggaggtgg   1740

tgcccaggcc gttctcctgc ctcctgccct gtgcccgcct cacttcatgt tcttcctcag   1800

atgagaggga gggtggacac ccccaggaat ctcttccctg caccttggcc ccctgcccct   1860

ggaggagccc agcttcttct ccagagccta gcagcccaga atctgagagc agaggccctg   1920

gtcccaggcc cagccctgca tcgtcccagg agggcagccc gcagcttcaa caccacagct   1980

caggcatttt gcccaagtgg acactagatg cttcacagtc ttcactcttg gagacggatg   2040

gggaacagcc aagttccttg aagaaaaagg aggcagggga ggccccaaaa ccaggcgagg   2100

aagtaaagag tgaaggaaca gccaggcctg cagagactgg agacgtccag cctgacattc   2160

acctgacttc tgcagaacat gagaatctga ggacaccgat gaactcttct tggcttcctg   2220

ggagccctat gccccaagca cagtccccag aggaaggcca gagaccacca gctggagaca   2280

agctagctaa tggcgtcagg aacaacaagg tagcctggaa cttggcctca cgcctctatc   2340

gcctggaggg cttccggaag tctgaagtgg ctgcctacct gcagaagaac aatgacttta   2400

gcagggctgt ggctgaggag tacctgtcct tcttccagtt tggaggccag agtctggacc   2460

gagccctccg gagcttcctc caggccttgg tgctcagtgg ggagactcag gaacgggagc   2520

gaatcctcta ccagttctcc agacgcttcc accattgcaa tccggggatc ttcccctcag   2580

tagattctgt acacaccttg acatgtgcaa tcatgctgct taacacggac ctgcatggac   2640

agaacattgg gaagagcatg agctgccagg aattcataac caacctgaat gggctgaggg   2700

atggcgggaa cttccccaag gagctgctga aggccctcta ctggtctatc cgcagcgaga   2760

agctcgagtg ggccgtggat gaagaagaca cagccagacc tgagaaggcc cagccgtccc   2820

tgccagctgg caagatgagc aagcccttcc ttcagctggc tcaggatccc acagtgccca   2880

cctacaagca gggcatcctg gctcggaaaa tgcatcaaga tgcagacggc aagaagacgc   2940

catggggcaa gcgtggctgg aagatgttcc acaccttact gcgagggatg gttctctact   3000

tcctgaagca gggagaagac cactgtctgg agggggagag cttggtgggg cagatggtgg   3060

atgagcccgt gggggtgcac cactcgctgg ccacccccgc cacgcattac accaagaagc   3120

cgcacgtctt ccagctgcgc acggctgact ggcgcctcta cctcttccag gcacccactg   3180

ccaaggagat gagctcctgg atcgcgcgca tcaacttggc tgcggccacg cactccgcgc   3240

cgcccttccc cgccgctgtg ggctcccagc gcagattcgt gcggcccatc ctgcccgtgg   3300

gccccgccca gagctccctg gaggagcagc atcgatccca cgagaactgc ctggacgctg   3360

ccgcggacga cctgctggat ctacagagga acctgccgga gcggcggggc cgtggccgcg   3420

agctggagga gcaccgcctg cggaaggagt acctggagta cgagaaaacc cgctacgaga   3480

cctacgtgca gctgctggtg gcccgcctgc actgcccctc tgatgctctg gacctgtggg   3540

aggagcagct ggggagggaa gctggaggca ctcgggagcc caagctcagc ctgaagaagt   3600

cccactcgag cccgtccctg caccaggatg aggctcccac cacggccaag gtgaagcgca   3660

acatctcaga gcgcagaacc taccggaaga tcatccctaa gcggaaccgc aatcagctgt   3720

gaagccagca ccacctcaga gacactgttc cctgctccag ggtagacctg agatgaacct   3780

ccctggagga gacttatttc aatgagtcca ccatgacgga tgaggcacct cctttccctg   3840

ctgaaggaca aaccttgttt ccctgtggcc ctcattcttg tgctccctga agctttccta   3900

atattgctgt gctccccacc acccccatgg cagtccctcc gcagccccag tccctggcca   3960

cgcccaaggg aagagggagg tgaggacttg actttcctcc cagagctcag cccatgtcac   4020

cctccaggcc ccagaatcca gagtggcctc atttcctaga cttgctgaga actcagcact   4080

tgtttgagaa ccagtgctta tgtggtgtgc ccttggcttc tgggggagag cttggggcag   4140

cagaggcccc tgggcagccc agccagggga gccacagccc caaggatggt cttgctctgg   4200

gaattaggtg accttcctgg ggaggcccca ggagagtgaa tcagggactc ttgagaaatt   4260

cctaaccagc ctcctgtgac ccagggagca gggtcgctaa ggtcctgccc actgagggga   4320

cagccttctg ggcagggacc tcggggggct tcaagggctc tgcacggctg tggggccctg   4380

tgcctttgtc tccttgtgtc tcctttcccc cgaagtagat gaaacagtct cacataccca   4440

actgctcatc aacagagcag agctgatggc atgagtgagg gctgggcggg gtggggcctc   4500

cagagctttg cagggaaccc tggaacccta ggaacaagga gcctttgttc caacagagca   4560

gagaaggagg ttctctatgt tcagaccact ggagaggata gagaggtaaa aggtggcgac   4620

agtttccctt aggggtctgc ctggcaggag ccacagctca ggagagttgt gagggatggg   4680

acggaggctg gcgaccaggc gaggcctagg ccaggctcgg gagacttttc tgtgctcctt   4740

tctacacatg ccttaaacct tccttcctgt ggggtgcctg gaccccttcc ccatctctgg   4800

cagctcagag ggtctctgct gctctcccct gggaaatccc ctcatcctgc cctctggctg   4860

cctcccagct gggcttgttc tctgagggag gttccggaga ctcatggact tggggctctg   4920

cctgtaggaa ggaggctggg ccggagggac cagccaccat tgtctctgtt cagccaagtg   4980

tgcaagtagg ctgcccgcca agagggggcc tctgctaccc gctgctgcct gccggctgac   5040

acactgcctc cccagccttc ctgctaggcc accctcctcc cttcccatgc ttgtaaccag   5100

ctctggggct tgcacctcca caaagtaagg ttggcccttg gaggccatgt ttgggtctcc   5160

ggccagggcc tagggctagg ccatgcaccc aatgggtgca caataaataa caggtcaaca   5220

aagagggagg tgtgtcagtg tgtgaggaag ggaggtcagg cagctaggac cacctgcagt   5280

gtggcaggct tcatccctct ttgctccaag tgtgtatgtg tgtctgtgca tgtgtgtagt   5340

gtctgtgtct gtgtgttcat gcatatgcag gagtcacacg gtcataggcc atcaaagctg   5400

gaggagacct cagaatcatt cattcaccta cttgctcatt tattcattca ttcattttgc   5460

agataatatg ggacgctttc tatgtgccag taccagggga ttcacaaatg aattaaacat   5520

gtccctgact ccatgagttg aca                                           5543


<210>  1493
<211>  677
<212>  PRT
<213>  Homo sapiens

<400>  1493


Met Leu Pro Gly Ser Arg Gly Gly Ala Pro Gly Arg Glu Pro Leu Glu 
1               5                   10                  15      


Val Val Pro Arg Pro Phe Ser Cys Leu Leu Pro Cys Ala Arg Leu Thr 
            20                  25                  30          


Ser Cys Ser Ser Ser Asp Glu Arg Glu Gly Gly His Pro Gln Glu Ser 
        35                  40                  45              


Leu Pro Cys Thr Leu Ala Pro Cys Pro Trp Arg Ser Pro Ala Ser Ser 
    50                  55                  60                  


Pro Glu Pro Ser Ser Pro Glu Ser Glu Ser Arg Gly Pro Gly Pro Arg 
65                  70                  75                  80  


Pro Ser Pro Ala Ser Ser Gln Glu Gly Ser Pro Gln Leu Gln His His 
                85                  90                  95      


Ser Ser Gly Ile Leu Pro Lys Trp Thr Leu Asp Ala Ser Gln Ser Ser 
            100                 105                 110         


Leu Leu Glu Thr Asp Gly Glu Gln Pro Ser Ser Leu Lys Lys Lys Glu 
        115                 120                 125             


Ala Gly Glu Ala Pro Lys Pro Gly Glu Glu Val Lys Ser Glu Gly Thr 
    130                 135                 140                 


Ala Arg Pro Ala Glu Thr Gly Asp Val Gln Pro Asp Ile His Leu Thr 
145                 150                 155                 160 


Ser Ala Glu His Glu Asn Leu Arg Thr Pro Met Asn Ser Ser Trp Leu 
                165                 170                 175     


Pro Gly Ser Pro Met Pro Gln Ala Gln Ser Pro Glu Glu Gly Gln Arg 
            180                 185                 190         


Pro Pro Ala Gly Asp Lys Leu Ala Asn Gly Val Arg Asn Asn Lys Val 
        195                 200                 205             


Ala Trp Asn Leu Ala Ser Arg Leu Tyr Arg Leu Glu Gly Phe Arg Lys 
    210                 215                 220                 


Ser Glu Val Ala Ala Tyr Leu Gln Lys Asn Asn Asp Phe Ser Arg Ala 
225                 230                 235                 240 


Val Ala Glu Glu Tyr Leu Ser Phe Phe Gln Phe Gly Gly Gln Ser Leu 
                245                 250                 255     


Asp Arg Ala Leu Arg Ser Phe Leu Gln Ala Leu Val Leu Ser Gly Glu 
            260                 265                 270         


Thr Gln Glu Arg Glu Arg Ile Leu Tyr Gln Phe Ser Arg Arg Phe His 
        275                 280                 285             


His Cys Asn Pro Gly Ile Phe Pro Ser Val Asp Ser Val His Thr Leu 
    290                 295                 300                 


Thr Cys Ala Ile Met Leu Leu Asn Thr Asp Leu His Gly Gln Asn Ile 
305                 310                 315                 320 


Gly Lys Ser Met Ser Cys Gln Glu Phe Ile Thr Asn Leu Asn Gly Leu 
                325                 330                 335     


Arg Asp Gly Gly Asn Phe Pro Lys Glu Leu Leu Lys Ala Leu Tyr Trp 
            340                 345                 350         


Ser Ile Arg Ser Glu Lys Leu Glu Trp Ala Val Asp Glu Glu Asp Thr 
        355                 360                 365             


Ala Arg Pro Glu Lys Ala Gln Pro Ser Leu Pro Ala Gly Lys Met Ser 
    370                 375                 380                 


Lys Pro Phe Leu Gln Leu Ala Gln Asp Pro Thr Val Pro Thr Tyr Lys 
385                 390                 395                 400 


Gln Gly Ile Leu Ala Arg Lys Met His Gln Asp Ala Asp Gly Lys Lys 
                405                 410                 415     


Thr Pro Trp Gly Lys Arg Gly Trp Lys Met Phe His Thr Leu Leu Arg 
            420                 425                 430         


Gly Met Val Leu Tyr Phe Leu Lys Gln Gly Glu Asp His Cys Leu Glu 
        435                 440                 445             


Gly Glu Ser Leu Val Gly Gln Met Val Asp Glu Pro Val Gly Val His 
    450                 455                 460                 


His Ser Leu Ala Thr Pro Ala Thr His Tyr Thr Lys Lys Pro His Val 
465                 470                 475                 480 


Phe Gln Leu Arg Thr Ala Asp Trp Arg Leu Tyr Leu Phe Gln Ala Pro 
                485                 490                 495     


Thr Ala Lys Glu Met Ser Ser Trp Ile Ala Arg Ile Asn Leu Ala Ala 
            500                 505                 510         


Ala Thr His Ser Ala Pro Pro Phe Pro Ala Ala Val Gly Ser Gln Arg 
        515                 520                 525             


Arg Phe Val Arg Pro Ile Leu Pro Val Gly Pro Ala Gln Ser Ser Leu 
    530                 535                 540                 


Glu Glu Gln His Arg Ser His Glu Asn Cys Leu Asp Ala Ala Ala Asp 
545                 550                 555                 560 


Asp Leu Leu Asp Leu Gln Arg Asn Leu Pro Glu Arg Arg Gly Arg Gly 
                565                 570                 575     


Arg Glu Leu Glu Glu His Arg Leu Arg Lys Glu Tyr Leu Glu Tyr Glu 
            580                 585                 590         


Lys Thr Arg Tyr Glu Thr Tyr Val Gln Leu Leu Val Ala Arg Leu His 
        595                 600                 605             


Cys Pro Ser Asp Ala Leu Asp Leu Trp Glu Glu Gln Leu Gly Arg Glu 
    610                 615                 620                 


Ala Gly Gly Thr Arg Glu Pro Lys Leu Ser Leu Lys Lys Ser His Ser 
625                 630                 635                 640 


Ser Pro Ser Leu His Gln Asp Glu Ala Pro Thr Thr Ala Lys Val Lys 
                645                 650                 655     


Arg Asn Ile Ser Glu Arg Arg Thr Tyr Arg Lys Ile Ile Pro Lys Arg 
            660                 665                 670         


Asn Arg Asn Gln Leu 
        675         

<210>  1494
<211>  5107
<212>  DNA
<213>  Homo sapiens

<400>  1494
acattcactg ggcaagccga ctgtgagcca ggaagtgctc ttggggagcc caggccaagc     60

catccattct tgggtccttt ggagggtaga tatggattcc cagtttctcc agcggccagt    120

gctcccccta gtccacacag tgagaccgtg aaagcagatg ctccggggca ctcctgggca    180

gcttttgctc agtggatgat gggtgactac agactccctg accaccccca gcccatggaa    240

attctcaacc tgtacttggg agacagcctg gagccccacc caggagagtg cccaagggaa    300

acgtgcagcc atgaggatcc accggagcct ttcgaggagc aaacctgggc cactgaccct    360

cctgaaccta ccagacaaaa tgttcctccc tggggctccg gtgtggagct cacacacctg    420

gggagctggg tccatcagga cgggctggag ccttgccagg agcaaacccg ggccactgac    480

cctcctgaat ctaccagaca agatgctcct ccctggggct ccggtgtgga gctcacacac    540

ctggggagcc cctctgccca gagggagcac aggcagaaca cagcatcacc agggtcacca    600

gtgaacagcc atctaccggg gagcccaaag cagaaccgga gcacgtccac acaggtagtg    660

ttctgggcag gcatcctgca ggcccagatg tgtgtcctag acctggagga ggagctggag    720

aagacggaag ggctcaaggc tgggctgaaa tgctgtctcc ccacgccccc tgtggacctc    780

cccggggaca cgggcctgca ctccagccca cctgagaatg aagactcagg ggaagacagc    840

agtgagcctg agggagaggg ccaggcatgg ctgagagagg gaaccccaga ctcttcccca    900

cagtggggag ctgaggagga gagcatgttc ttcagcaacc ccctcttcct ggcgagtcct    960

tgctcagaga acagtgcttc tggagagtgc ttttcctggg gggcttcaga ctcccatgca   1020

ggtgtgagga ctggacctga gagcccagcg actctggagc ctcccctccc agaagacaca   1080

gtgctgtggg agctggaaag tgagccagat ttgggggacg gcgctgctat cagtgggcat   1140

tgtacccctc cattccctgt gcccatctat aaaccacact ccatctgctg ggcctcagtg   1200

gctgccgctg agggggctcc tgcagcacct cctggtcacg gggagagtga gggagatagg   1260

cttggtcctg ctccatctgc agcaccgggc ctctctcagc cctgagggct ggcagagagg   1320

aggtcctttt tggccccagg tgactcttaa ctcccaggac agagatgaga gggagggtgg   1380

acacccccag gaatctcttc cctgcacctt ggccccctgc ccctggagga gcccagcttc   1440

ttctccagag cctagcagcc cagaatctga gagcagaggc cctggtccca ggcccagccc   1500

tgcatcgtcc caggagggca gcccgcagct tcaacaccac agctcaggca ttttgcccaa   1560

gtggacacta gatgcttcac agtcttcact cttggagacg gatggggaac agccaagttc   1620

cttgaagaaa aaggaggcag gggaggcccc aaaaccaggc gaggaagtaa agagtgaagg   1680

aacagccagg cctgcagaga ctggagacgt ccagcctgac attcacctga cttctgcaga   1740

acatgagaat ctgaggacac cgatgaactc ttcttggctt cctgggagcc ctatgcccca   1800

agcacagtcc ccagaggaag gccagagacc accagctgga gacaagctag ctaatggcgt   1860

caggaacaac aaggtagcct ggaacttggc ctcacgcctc tatcgcctgg agggcttccg   1920

gaagtctgaa gtggctgcct acctgcagaa gaacaatgac tttagcaggg ctgtggctga   1980

ggagtacctg tccttcttcc agtttggagg ccagagtctg gaccgagccc tccggagctt   2040

cctccaggcc ttggtgctca gtggggagac tcaggaacgg gagcgaatcc tctaccagtt   2100

ctccagacgc ttccaccatt gcaatccggg gatcttcccc tcagtagatt ctgtacacac   2160

cttgacatgt gcaatcatgc tgcttaacac ggacctgcat ggacagaaca ttgggaagag   2220

catgagctgc caggaattca taaccaacct gaatgggctg agggatggcg ggaacttccc   2280

caaggagctg ctgaaggccc tctactggtc tatccgcagc gagaagctcg agtgggccgt   2340

ggatgaagaa gacacagcca gacctgagaa ggcccagccg tccctgccag ctggcaagat   2400

gagcaagccc ttccttcagc tggctcagga tcccacagtg cccacctaca agcagggcat   2460

cctggctcgg aaaatgcatc aagatgcaga cggcaagaag acgccatggg gcaagcgtgg   2520

ctggaagatg ttccacacct tactgcgagg gatggttctc tacttcctga agcagggaga   2580

agaccactgt ctggaggggg agagcttggt ggggcagatg gtggatgagc ccgtgggggt   2640

gcaccactcg ctggccaccc ccgccacgca ttacaccaag aagccgcacg tcttccagct   2700

gcgcacggct gactggcgcc tctacctctt ccaggcaccc actgccaagg agatgagctc   2760

ctggatcgcg cgcatcaact tggctgcggc cacgcactcc gcgccgccct tccccgccgc   2820

tgtgggctcc cagcgcagat tcgtgcggcc catcctgccc gtgggccccg cccagagctc   2880

cctggaggag cagcatcgat cccacgagaa ctgcctggac gctgccgcgg acgacctgct   2940

ggatctacag aggaacctgc cggagcggcg gggccgtggc cgcgagctgg aggagcaccg   3000

cctgcggaag gagtacctgg agtacgagaa aacccgctac gagacctacg tgcagctgct   3060

ggtggcccgc ctgcactgcc cctctgatgc tctggacctg tgggaggagc agctggggag   3120

ggaagctgga ggcactcggg agcccaagct cagcctgaag aagtcccact cgagcccgtc   3180

cctgcaccag gatgaggctc ccaccacggc caaggtgaag cgcaacatct cagagcgcag   3240

aacctaccgg aagatcatcc ctaagcggaa ccgcaatcag ctgtgaagcc agcaccacct   3300

cagagacact gttccctgct ccagggtaga cctgagatga acctccctgg aggagactta   3360

tttcaatgag tccaccatga cggatgaggc acctcctttc cctgctgaag gacaaacctt   3420

gtttccctgt ggccctcatt cttgtgctcc ctgaagcttt cctaatattg ctgtgctccc   3480

caccaccccc atggcagtcc ctccgcagcc ccagtccctg gccacgccca agggaagagg   3540

gaggtgagga cttgactttc ctcccagagc tcagcccatg tcaccctcca ggccccagaa   3600

tccagagtgg cctcatttcc tagacttgct gagaactcag cacttgtttg agaaccagtg   3660

cttatgtggt gtgcccttgg cttctggggg agagcttggg gcagcagagg cccctgggca   3720

gcccagccag gggagccaca gccccaagga tggtcttgct ctgggaatta ggtgaccttc   3780

ctggggaggc cccaggagag tgaatcaggg actcttgaga aattcctaac cagcctcctg   3840

tgacccaggg agcagggtcg ctaaggtcct gcccactgag gggacagcct tctgggcagg   3900

gacctcgggg ggcttcaagg gctctgcacg gctgtggggc cctgtgcctt tgtctccttg   3960

tgtctccttt cccccgaagt agatgaaaca gtctcacata cccaactgct catcaacaga   4020

gcagagctga tggcatgagt gagggctggg cggggtgggg cctccagagc tttgcaggga   4080

accctggaac cctaggaaca aggagccttt gttccaacag agcagagaag gaggttctct   4140

atgttcagac cactggagag gatagagagg taaaaggtgg cgacagtttc ccttaggggt   4200

ctgcctggca ggagccacag ctcaggagag ttgtgaggga tgggacggag gctggcgacc   4260

aggcgaggcc taggccaggc tcgggagact tttctgtgct cctttctaca catgccttaa   4320

accttccttc ctgtggggtg cctggacccc ttccccatct ctggcagctc agagggtctc   4380

tgctgctctc ccctgggaaa tcccctcatc ctgccctctg gctgcctccc agctgggctt   4440

gttctctgag ggaggttccg gagactcatg gacttggggc tctgcctgta ggaaggaggc   4500

tgggccggag ggaccagcca ccattgtctc tgttcagcca agtgtgcaag taggctgccc   4560

gccaagaggg ggcctctgct acccgctgct gcctgccggc tgacacactg cctccccagc   4620

cttcctgcta ggccaccctc ctcccttccc atgcttgtaa ccagctctgg ggcttgcacc   4680

tccacaaagt aaggttggcc cttggaggcc atgtttgggt ctccggccag ggcctagggc   4740

taggccatgc acccaatggg tgcacaataa ataacaggtc aacaaagagg gaggtgtgtc   4800

agtgtgtgag gaagggaggt caggcagcta ggaccacctg cagtgtggca ggcttcatcc   4860

ctctttgctc caagtgtgta tgtgtgtctg tgcatgtgtg tagtgtctgt gtctgtgtgt   4920

tcatgcatat gcaggagtca cacggtcata ggccatcaaa gctggaggag acctcagaat   4980

cattcattca cctacttgct catttattca ttcattcatt ttgcagataa tatgggacgc   5040

tttctatgtg ccagtaccag gggattcaca aatgaattaa acatgtccct gactccatga   5100

gttgaca                                                             5107


<210>  1495
<211>  507
<212>  PRT
<213>  Homo sapiens

<400>  1495


Met Asn Ser Ser Trp Leu Pro Gly Ser Pro Met Pro Gln Ala Gln Ser 
1               5                   10                  15      


Pro Glu Glu Gly Gln Arg Pro Pro Ala Gly Asp Lys Leu Ala Asn Gly 
            20                  25                  30          


Val Arg Asn Asn Lys Val Ala Trp Asn Leu Ala Ser Arg Leu Tyr Arg 
        35                  40                  45              


Leu Glu Gly Phe Arg Lys Ser Glu Val Ala Ala Tyr Leu Gln Lys Asn 
    50                  55                  60                  


Asn Asp Phe Ser Arg Ala Val Ala Glu Glu Tyr Leu Ser Phe Phe Gln 
65                  70                  75                  80  


Phe Gly Gly Gln Ser Leu Asp Arg Ala Leu Arg Ser Phe Leu Gln Ala 
                85                  90                  95      


Leu Val Leu Ser Gly Glu Thr Gln Glu Arg Glu Arg Ile Leu Tyr Gln 
            100                 105                 110         


Phe Ser Arg Arg Phe His His Cys Asn Pro Gly Ile Phe Pro Ser Val 
        115                 120                 125             


Asp Ser Val His Thr Leu Thr Cys Ala Ile Met Leu Leu Asn Thr Asp 
    130                 135                 140                 


Leu His Gly Gln Asn Ile Gly Lys Ser Met Ser Cys Gln Glu Phe Ile 
145                 150                 155                 160 


Thr Asn Leu Asn Gly Leu Arg Asp Gly Gly Asn Phe Pro Lys Glu Leu 
                165                 170                 175     


Leu Lys Ala Leu Tyr Trp Ser Ile Arg Ser Glu Lys Leu Glu Trp Ala 
            180                 185                 190         


Val Asp Glu Glu Asp Thr Ala Arg Pro Glu Lys Ala Gln Pro Ser Leu 
        195                 200                 205             


Pro Ala Gly Lys Met Ser Lys Pro Phe Leu Gln Leu Ala Gln Asp Pro 
    210                 215                 220                 


Thr Val Pro Thr Tyr Lys Gln Gly Ile Leu Ala Arg Lys Met His Gln 
225                 230                 235                 240 


Asp Ala Asp Gly Lys Lys Thr Pro Trp Gly Lys Arg Gly Trp Lys Met 
                245                 250                 255     


Phe His Thr Leu Leu Arg Gly Met Val Leu Tyr Phe Leu Lys Gln Gly 
            260                 265                 270         


Glu Asp His Cys Leu Glu Gly Glu Ser Leu Val Gly Gln Met Val Asp 
        275                 280                 285             


Glu Pro Val Gly Val His His Ser Leu Ala Thr Pro Ala Thr His Tyr 
    290                 295                 300                 


Thr Lys Lys Pro His Val Phe Gln Leu Arg Thr Ala Asp Trp Arg Leu 
305                 310                 315                 320 


Tyr Leu Phe Gln Ala Pro Thr Ala Lys Glu Met Ser Ser Trp Ile Ala 
                325                 330                 335     


Arg Ile Asn Leu Ala Ala Ala Thr His Ser Ala Pro Pro Phe Pro Ala 
            340                 345                 350         


Ala Val Gly Ser Gln Arg Arg Phe Val Arg Pro Ile Leu Pro Val Gly 
        355                 360                 365             


Pro Ala Gln Ser Ser Leu Glu Glu Gln His Arg Ser His Glu Asn Cys 
    370                 375                 380                 


Leu Asp Ala Ala Ala Asp Asp Leu Leu Asp Leu Gln Arg Asn Leu Pro 
385                 390                 395                 400 


Glu Arg Arg Gly Arg Gly Arg Glu Leu Glu Glu His Arg Leu Arg Lys 
                405                 410                 415     


Glu Tyr Leu Glu Tyr Glu Lys Thr Arg Tyr Glu Thr Tyr Val Gln Leu 
            420                 425                 430         


Leu Val Ala Arg Leu His Cys Pro Ser Asp Ala Leu Asp Leu Trp Glu 
        435                 440                 445             


Glu Gln Leu Gly Arg Glu Ala Gly Gly Thr Arg Glu Pro Lys Leu Ser 
    450                 455                 460                 


Leu Lys Lys Ser His Ser Ser Pro Ser Leu His Gln Asp Glu Ala Pro 
465                 470                 475                 480 


Thr Thr Ala Lys Val Lys Arg Asn Ile Ser Glu Arg Arg Thr Tyr Arg 
                485                 490                 495     


Lys Ile Ile Pro Lys Arg Asn Arg Asn Gln Leu 
            500                 505         

<210>  1496
<211>  714
<212>  DNA
<213>  Homo sapiens

<400>  1496
ggatagatag taggagagag gcctggaaca gatccttccc tagcatcttc agagggagca     60

tggacctacc tacaccttga tctcataatc cagtctccaa aatggaagga cacttctata    120

aaagacggag ttggttgtac ttcccatgaa accattattg aagacacaca tttgcataac    180

agcaatgaga gaaaaattgc cgtggccaaa atcatctgaa gaaattagaa gcatgagact    240

aggacaaaga aggaagagca ggactgggaa gcaagattca gcccagggtc agaaatccag    300

gctcctttgc ccatctaata agaaagaatg aaagttgaaa gccgctctca gaaatggaca    360

tgtaagaaga catacacagg tatcaattca tatatccata caggaaagaa ggaaggaagg    420

aaggaaggaa ggaaggaagg aaggaaggaa ggaaggaagg aaggaaggag gataccccaa    480

gtataaatgg attcaagcta cttggaattt ggtaagtgtg attctcactt gagggtgagg    540

tggtctagac ctatgtatgc cacaggggag aagcagtcaa acttaagtct gataaagaat    600

catcacaggt catgttaaaa gtagattcca gtattctcct caaagattct gattcatttg    660

gtctggaaaa ggatcctgta acctctccag attaatctaa aatatagggt cgag          714


<210>  1497
<211>  61
<212>  PRT
<213>  Homo sapiens

<400>  1497


Met Lys Pro Leu Leu Lys Thr His Ile Cys Ile Thr Ala Met Arg Glu 
1               5                   10                  15      


Lys Leu Pro Trp Pro Lys Ser Ser Glu Glu Ile Arg Ser Met Arg Leu 
            20                  25                  30          


Gly Gln Arg Arg Lys Ser Arg Thr Gly Lys Gln Asp Ser Ala Gln Gly 
        35                  40                  45              


Gln Lys Ser Arg Leu Leu Cys Pro Ser Asn Lys Lys Glu 
    50                  55                  60      

<210>  1498
<211>  7361
<212>  DNA
<213>  Homo sapiens

<400>  1498
atttgagcat cagttgaggg agaggacgct tcatttcctt tttggttggg aatgtgccgt     60

gaacatcctc tgctggagct tggggcctgg agcaaactgg ggctgcagat ttagacgtag    120

acgtttccga ggacgcgaga ctgcagagct ttgtaggcag ccaatcccag agaagcagac    180

gggatggcta gttcagcccg ggagcacctg ctttttgtga ggcgtcgaaa tccccagatg    240

cggtacacat tgagcccaga gaacctccag agccttgccg cccagagctc catgccagag    300

aacatgaccc tgcagcgggc caacagcgac accgacctgg tgacttctga gagccgctcc    360

agcttaactg ccagcatgta cgagtacacg ctggggcaag cccagaacct cattatcttc    420

tgggacatta aagaggaggt ggaccccagt gattggattg gactttatca tatagatgag    480

aattctccag ccaacttctg ggattctaag aacaggggtg tgactggaac acaaaaaggg    540

caaattgtat ggagaattga gcctgggccc tatttcatgg aaccggagat aaaaatctgt    600

tttaaatatt accacggcat tagtggagcc ctgcgagcca cgaccccctg catcaccgtg    660

aagaacccag ctgtgatgat gggggcagaa ggcatggagg gaggtgcttc aggaaacctg    720

cattctcgaa aacttgttag ctttacattg tcagatctta gggcagttgg gctaaagaaa    780

gggatgttct tcaatcctga cccttatctt aagatgtcaa ttcagccagg aaagaagagc    840

agtttcccca cctgtgccca ccacgggcag gagagacggt ctactatcat cagtaacacc    900

accaatccaa tttggcaccg agagaaatat tccttttttg cacttcttac tgatgtctta    960

gaaattgaaa ttaaagacaa atttgccaag agccgtccca tcatcaagcg ttttctgggg   1020

aaactaacca ttccagtcca gaggctgctg gagcgacaag ccatcggtga tcaaatgctc   1080

agctacaacc ttggcagaag gctcccagct gaccacgtga gtgggtacct ccagtttaaa   1140

gtggaggtta cgtcttctgt tcatgaagat gcctctccag aagctgttgg cacaatactt   1200

ggagtcaatt ctgtgaatgg agacttaggt agcccttccg atgacgagga catgccaggg   1260

agccatcacg acagccaggt gtgctctaat gggccagttt ctgaggacag tgctgccgat   1320

ggaaccccca agcattcatt caggactagc tccactctgg aaatagacac agaggaatta   1380

acctctacgt cttcaaggac ctcacctccc agaggacgtc aggattcact caatgattac   1440

ttagatgcta tcgaacacaa tggccactcc aggccgggga cagcgacctg ctctgagagg   1500

tccatgggtg cctctccgaa actgaggagt agttttccca ctgacacaag actcaatgcc   1560

atgcttcata ttgattcaga tgaagaagat cacgagttcc agcaagacct gggttaccca   1620

tcttccttgg aggaggaggg aggcctgatc atgtttagca gggcatccag agctgatgat   1680

ggaagcctga catctcagac aaagctggag gacaaccctg ttgagaatga ggaagcctcc   1740

acacacgaag ctgcttcctt tgaggataag ccagaaaatc ttccagagct tgcagagagc   1800

tccttacctg caggcccagc cccagaggaa ggtgaaggcg gcccagagcc tcaacccagt   1860

gctgaccagg gcagtgctga actgtgtggc tctcaagagg tagatcagcc cacaagtggc   1920

gcagacacag ggacttccga tgcatcagga ggaagccgaa gagccgtcag tgagaccgag   1980

tctctcgatc agggctctga gccttcccag gtgtcctctg aaacagaacc cagtgatcct   2040

gccaggacag agagtgtgag cgaagccagc accaggcctg agggagagag tgacctggaa   2100

tgcgctgaca gctcctgcaa tgagagtgtg accacgcagc tgtcctctgt ggacacacgg   2160

tgctcctctc ttgagagcgc acggtttcct gaaaccccag ccttttcttc tcaggaggag   2220

gaagacggag cctgtgcagc agagcccacc agcagtggcc ctgccgaagg gtcgcaggaa   2280

tccgtgtgca ctgctggttc tttacctgtg gtacaggtgc ccagtgggga ggatgaaggg   2340

ccaggggcag aatcggccac tgtacctgac caggaggagc tgggggaggt ctggcagcgg   2400

agggggagcc tggagggagc tgcagctgct gccgagagcc caccgcaaga agaaggcagt   2460

gctggggagg cccaaggcac ctgtgaaggg gcaactgccc aggaggaggg cgctactgga   2520

ggttctcaag ccaacggcca ccagccactg cgatcactac cttcagtgcg ccaggatgtt   2580

agccggtacc agagggtgga cgaggctctc ccaccaaact gggaggcacg cattgacagc   2640

cacggcagga tcttctacgt ggatcacgta aacagaacca cgacgtggca gcgaccgaca   2700

gctcccccag ccccgcaggt gctgcagaga tctaactcca tacagcaaat ggagcagctg   2760

aaccggcgat atcagagtat ccgcagaacc atgaccaatg agaggcctga ggaaaatacc   2820

aatgctattg atggggcagg ggaggaagct gactttcacc aagccagtgc agatttccga   2880

cgggagaaca tcctgcctca ctctacctcc agatccagga tcacgttgct gttacagtct   2940

ccccccgtga agttcctcat cagcccagag ttcttcaccg tgctgcattc taaccctagt   3000

gcctaccgca tgtttacaaa caacacgtgt ttgaagcaca tgatcaccaa agtccggagg   3060

gacacccacc actttgaacg ctaccagcat aaccgcgacc ttgtgggatt cctcaacatg   3120

ttcgcgaaca aacagctaga gctgccgcgg ggatgggaaa tgaaacatga tcaccagggc   3180

aaggcattct ttgtggacca caactcccgc accaccactt tcattgatcc ccggctccca   3240

cttcagagca gtagacccac aagtgcgctg gttcatcggc aacacctgac aaggcaacgc   3300

agccacagtg cgggtgaggt aggagaagat tctcgacatg caggaccacc agttcttccc   3360

aggccatcca gtacattcaa tacagtcagt aggccacagt accaggacat ggttccagtg   3420

gcttacaatg acaagattgt tgcatttcta cgtcaaccca atatctttga aattctacag   3480

gagcgtcaac ctgatcttac caggaatcac tcactcaggg agaagatcca atttatccga   3540

actgaaggga ctccaggatt ggtgcgcctt tcaagcgatg cagaccttgt tatgttgctg   3600

agcttatttg aagaagagat aatgtcgtat gtgcctccac atgccttact ccaccccagc   3660

tactgtcagt ccccacgtgg ctctcccgtg tcatctcctc agaactcgcc aggtacccag   3720

cgtgccaatg cccgggctcc agccccttac aagcgggatt tcgaagccaa actgaggaac   3780

ttttacagga agttagagac taaaggatat ggacaaggcc cagggaagtt aaagttaatt   3840

atccgaagag atcacttact agaagatgct tttaatcaga ttatgggcta ctccagaaaa   3900

gacctgcaga gaaataagct atatgtcacc ttcgttgggg aggaagggct ggattacagt   3960

gggccttcta gagagttttt cttcctggta tccagagaac tctttaaccc atattatggc   4020

ttatttgaat attcagccaa tgacacatac acagtacaaa taagtcctat gtctgctttt   4080

gtagacaatc accatgaatg gttccgattc agtggtagga tccttggtct tgcactaata   4140

caccagtatt tgttggatgc cttcttcaca cggccctttt ataaggctct tctcagaatt   4200

ctatgtgacc tgagtgacct agaatacctt gatgaagagt tccatcagag cctgcagtgg   4260

atgaaagaca atgatatcca tgacatccta gacctcacgt tcactgtgaa cgaagaagta   4320

tttgggcaga taactgaacg agaattaaag ccagggggtg ccaatatccc agttacagag   4380

aagaacaaga aggagtacat cgagaggatg gtgaagtgga ggattgagag gggtgttgta   4440

cagcaaacag agagcttagt gcgtggcttc tatgaggtgg tggatgccag gctggtatct   4500

gtttttgatg caagagaact ggaattggtc atcgcaggca cagctgaaat agacctaagt   4560

gattggagaa acaacacaga atatagagga ggataccatg acaatcatat tgtaattcgg   4620

tggttctggg ctgcagtgga aagattcaac aatgaacaac gactaaggtt gttacagttt   4680

gttacaggca catccagcat tccctatgaa ggatttgctt cactccgagg gagtaacggc   4740

ccaagaagat tctgtgtgga gaaatggggg aaaatcactg ctcttcccag agcgcataca   4800

tgttttaacc gtctggatct gcctccctac ccatcctttt ccatgcttta tgaaaaactg   4860

ttgacagcag ttgaagaaac cagtactttt ggacttgagt gacctggaag ctgaatgccc   4920

atctctgtgg acaggcaggt tcagaagctg ccttctagaa gaatgattga acattggaag   4980

tttcaagagg atgcttcctt taggataaag ctatgtgctg ttgttttcca ggaacaagtg   5040

ctctgtcaca tttggggact ggagatgagt cctcttggaa ggatttgggt gagcttgatg   5100

cccagggaac aacccaaccg tctttcaatc aacagttctt gactgccaaa ctttttccat   5160

ttgttatgtt ccaagacaaa gatgaaccca tacatgatca gctccacggt aatttttagg   5220

gactcaggag aatcttgaaa cttacccttg aacgtggttc aagccaaact ggcagcattt   5280

ggcccaatct ccaaattaga gcaagttaaa taatataata aaagtaaata tatttcctga   5340

aagtacattc atttaagccc taagttataa cagaatattc atttcttgct tatgagtgcc   5400

tgcatggtgt gcaccatagg tttccgcttt catgggacat gagtgaaaat gaaaccaagt   5460

caatatgagg tacctttaca gatttgcaat aagatggtct gtgacaatgt atatgcaagt   5520

ggtatgtgtg taattatggc taaagacaaa ccattattca gtgaattact aatgacagat   5580

tttatgcttt ataatgcatg aaaacaattt taaaataact agcaattaat cacagcatat   5640

caggaaaaag tacacagtga gttctgttta ttttttgtag gttcattatg tttatgttct   5700

ttaagatgta tataagaacc tacctatcat gctgtatgta tcactcattc cattttcatg   5760

ttccatgcat actcgggcat catgctaata tgtatccttt taagcactct caaggaaaca   5820

aaagggcctt ttatttttat aaaggtaaaa aaaattcccc aaatattttg cactgaatgt   5880

accaaaggtg aagggacatt acaatatgac taacagcaac tccatcactt gagaagtata   5940

atagaaaata gcttctaaat caaacttcct tcacagtgcc gtgtctacca ctacaaggac   6000

tgtgcatcta agtaataatt ttttaagatt cactatatgt gatagtatga tatgcattta   6060

tttaaaatgc attagactct cttccatcca tcaaatactt tacaggatgg catttaatac   6120

agatatttcg tatttccccc actgcttttt atttgtacag catcattaaa cactaagctc   6180

agttaaggag ccatcagcaa cactgaagag atcagtagta agaattccat tttccctcat   6240

cagtgaagac accacaaatt gaaactcaga actatatttc taagcctgca ttttcactga   6300

tgcataattt tcttattaat attaagagac agtttttcta tggcatctcc aaaactgcat   6360

gacatcacta gtcttacttc tgcttaattt tatgagaagg tattcttcat tttaattgct   6420

tttgggatta ctccacatct ttgtttattt cttgactaat cagattttca atagagtgaa   6480

gttaaattgg gggtcataaa agcattggat tgacatatgg tttgccagcc tatgggttta   6540

caggcattgc ccaaacattt ctttgagatc tatatttata agcagccatg gaattcctat   6600

tatgggatgt tggcaatctt acattttata gaggtcatat gcatagtttt cataggtgtt   6660

ttgtaagaac tgattgctct cctgtgagtt aagctatgtt tactactggg accctcaaga   6720

ggaataccac ttatgttaca ctcctgcact aaaggcacgt actgcagtgt gaagaaatgt   6780

tctgaaaaag ggttatagaa atctggaaat aagaaaggaa gagctctctg tattctataa   6840

ttggaagaga aaaaaagaaa aacttttaac tggaaatgtt agtttgtact tattgatcat   6900

gaatacaagt atatatttaa ttttgcaaac ttttcacttg tttgtattct tttcattata   6960

aggaaaagta gtataacaca ctttttttta agtcacatat ttgatggtat acaagatgtt   7020

tcagggctgg cattctccaa gcagcagata aaggttgcat ttctttcaaa aatacattca   7080

aagaccatgt tatccttcat tttggtttga gacatttagt tatggtattt catattatta   7140

ggtaaaagat atttgaaata aaatgtatct ctttaattat ttctaacaaa tatatttctt   7200

tattaaggca tccaactttt tcccaaataa cagtacactt taatgtatgt agacattctt   7260

aattagtata atcatctagt tgatactgtt ctcagattgg gaattatcaa agatgtactt   7320

atcatatcag aacaccatgc taacttatct attattcttt c                       7361


<210>  1499
<211>  1572
<212>  PRT
<213>  Homo sapiens

<400>  1499


Met Ala Ser Ser Ala Arg Glu His Leu Leu Phe Val Arg Arg Arg Asn 
1               5                   10                  15      


Pro Gln Met Arg Tyr Thr Leu Ser Pro Glu Asn Leu Gln Ser Leu Ala 
            20                  25                  30          


Ala Gln Ser Ser Met Pro Glu Asn Met Thr Leu Gln Arg Ala Asn Ser 
        35                  40                  45              


Asp Thr Asp Leu Val Thr Ser Glu Ser Arg Ser Ser Leu Thr Ala Ser 
    50                  55                  60                  


Met Tyr Glu Tyr Thr Leu Gly Gln Ala Gln Asn Leu Ile Ile Phe Trp 
65                  70                  75                  80  


Asp Ile Lys Glu Glu Val Asp Pro Ser Asp Trp Ile Gly Leu Tyr His 
                85                  90                  95      


Ile Asp Glu Asn Ser Pro Ala Asn Phe Trp Asp Ser Lys Asn Arg Gly 
            100                 105                 110         


Val Thr Gly Thr Gln Lys Gly Gln Ile Val Trp Arg Ile Glu Pro Gly 
        115                 120                 125             


Pro Tyr Phe Met Glu Pro Glu Ile Lys Ile Cys Phe Lys Tyr Tyr His 
    130                 135                 140                 


Gly Ile Ser Gly Ala Leu Arg Ala Thr Thr Pro Cys Ile Thr Val Lys 
145                 150                 155                 160 


Asn Pro Ala Val Met Met Gly Ala Glu Gly Met Glu Gly Gly Ala Ser 
                165                 170                 175     


Gly Asn Leu His Ser Arg Lys Leu Val Ser Phe Thr Leu Ser Asp Leu 
            180                 185                 190         


Arg Ala Val Gly Leu Lys Lys Gly Met Phe Phe Asn Pro Asp Pro Tyr 
        195                 200                 205             


Leu Lys Met Ser Ile Gln Pro Gly Lys Lys Ser Ser Phe Pro Thr Cys 
    210                 215                 220                 


Ala His His Gly Gln Glu Arg Arg Ser Thr Ile Ile Ser Asn Thr Thr 
225                 230                 235                 240 


Asn Pro Ile Trp His Arg Glu Lys Tyr Ser Phe Phe Ala Leu Leu Thr 
                245                 250                 255     


Asp Val Leu Glu Ile Glu Ile Lys Asp Lys Phe Ala Lys Ser Arg Pro 
            260                 265                 270         


Ile Ile Lys Arg Phe Leu Gly Lys Leu Thr Ile Pro Val Gln Arg Leu 
        275                 280                 285             


Leu Glu Arg Gln Ala Ile Gly Asp Gln Met Leu Ser Tyr Asn Leu Gly 
    290                 295                 300                 


Arg Arg Leu Pro Ala Asp His Val Ser Gly Tyr Leu Gln Phe Lys Val 
305                 310                 315                 320 


Glu Val Thr Ser Ser Val His Glu Asp Ala Ser Pro Glu Ala Val Gly 
                325                 330                 335     


Thr Ile Leu Gly Val Asn Ser Val Asn Gly Asp Leu Gly Ser Pro Ser 
            340                 345                 350         


Asp Asp Glu Asp Met Pro Gly Ser His His Asp Ser Gln Val Cys Ser 
        355                 360                 365             


Asn Gly Pro Val Ser Glu Asp Ser Ala Ala Asp Gly Thr Pro Lys His 
    370                 375                 380                 


Ser Phe Arg Thr Ser Ser Thr Leu Glu Ile Asp Thr Glu Glu Leu Thr 
385                 390                 395                 400 


Ser Thr Ser Ser Arg Thr Ser Pro Pro Arg Gly Arg Gln Asp Ser Leu 
                405                 410                 415     


Asn Asp Tyr Leu Asp Ala Ile Glu His Asn Gly His Ser Arg Pro Gly 
            420                 425                 430         


Thr Ala Thr Cys Ser Glu Arg Ser Met Gly Ala Ser Pro Lys Leu Arg 
        435                 440                 445             


Ser Ser Phe Pro Thr Asp Thr Arg Leu Asn Ala Met Leu His Ile Asp 
    450                 455                 460                 


Ser Asp Glu Glu Asp His Glu Phe Gln Gln Asp Leu Gly Tyr Pro Ser 
465                 470                 475                 480 


Ser Leu Glu Glu Glu Gly Gly Leu Ile Met Phe Ser Arg Ala Ser Arg 
                485                 490                 495     


Ala Asp Asp Gly Ser Leu Thr Ser Gln Thr Lys Leu Glu Asp Asn Pro 
            500                 505                 510         


Val Glu Asn Glu Glu Ala Ser Thr His Glu Ala Ala Ser Phe Glu Asp 
        515                 520                 525             


Lys Pro Glu Asn Leu Pro Glu Leu Ala Glu Ser Ser Leu Pro Ala Gly 
    530                 535                 540                 


Pro Ala Pro Glu Glu Gly Glu Gly Gly Pro Glu Pro Gln Pro Ser Ala 
545                 550                 555                 560 


Asp Gln Gly Ser Ala Glu Leu Cys Gly Ser Gln Glu Val Asp Gln Pro 
                565                 570                 575     


Thr Ser Gly Ala Asp Thr Gly Thr Ser Asp Ala Ser Gly Gly Ser Arg 
            580                 585                 590         


Arg Ala Val Ser Glu Thr Glu Ser Leu Asp Gln Gly Ser Glu Pro Ser 
        595                 600                 605             


Gln Val Ser Ser Glu Thr Glu Pro Ser Asp Pro Ala Arg Thr Glu Ser 
    610                 615                 620                 


Val Ser Glu Ala Ser Thr Arg Pro Glu Gly Glu Ser Asp Leu Glu Cys 
625                 630                 635                 640 


Ala Asp Ser Ser Cys Asn Glu Ser Val Thr Thr Gln Leu Ser Ser Val 
                645                 650                 655     


Asp Thr Arg Cys Ser Ser Leu Glu Ser Ala Arg Phe Pro Glu Thr Pro 
            660                 665                 670         


Ala Phe Ser Ser Gln Glu Glu Glu Asp Gly Ala Cys Ala Ala Glu Pro 
        675                 680                 685             


Thr Ser Ser Gly Pro Ala Glu Gly Ser Gln Glu Ser Val Cys Thr Ala 
    690                 695                 700                 


Gly Ser Leu Pro Val Val Gln Val Pro Ser Gly Glu Asp Glu Gly Pro 
705                 710                 715                 720 


Gly Ala Glu Ser Ala Thr Val Pro Asp Gln Glu Glu Leu Gly Glu Val 
                725                 730                 735     


Trp Gln Arg Arg Gly Ser Leu Glu Gly Ala Ala Ala Ala Ala Glu Ser 
            740                 745                 750         


Pro Pro Gln Glu Glu Gly Ser Ala Gly Glu Ala Gln Gly Thr Cys Glu 
        755                 760                 765             


Gly Ala Thr Ala Gln Glu Glu Gly Ala Thr Gly Gly Ser Gln Ala Asn 
    770                 775                 780                 


Gly His Gln Pro Leu Arg Ser Leu Pro Ser Val Arg Gln Asp Val Ser 
785                 790                 795                 800 


Arg Tyr Gln Arg Val Asp Glu Ala Leu Pro Pro Asn Trp Glu Ala Arg 
                805                 810                 815     


Ile Asp Ser His Gly Arg Ile Phe Tyr Val Asp His Val Asn Arg Thr 
            820                 825                 830         


Thr Thr Trp Gln Arg Pro Thr Ala Pro Pro Ala Pro Gln Val Leu Gln 
        835                 840                 845             


Arg Ser Asn Ser Ile Gln Gln Met Glu Gln Leu Asn Arg Arg Tyr Gln 
    850                 855                 860                 


Ser Ile Arg Arg Thr Met Thr Asn Glu Arg Pro Glu Glu Asn Thr Asn 
865                 870                 875                 880 


Ala Ile Asp Gly Ala Gly Glu Glu Ala Asp Phe His Gln Ala Ser Ala 
                885                 890                 895     


Asp Phe Arg Arg Glu Asn Ile Leu Pro His Ser Thr Ser Arg Ser Arg 
            900                 905                 910         


Ile Thr Leu Leu Leu Gln Ser Pro Pro Val Lys Phe Leu Ile Ser Pro 
        915                 920                 925             


Glu Phe Phe Thr Val Leu His Ser Asn Pro Ser Ala Tyr Arg Met Phe 
    930                 935                 940                 


Thr Asn Asn Thr Cys Leu Lys His Met Ile Thr Lys Val Arg Arg Asp 
945                 950                 955                 960 


Thr His His Phe Glu Arg Tyr Gln His Asn Arg Asp Leu Val Gly Phe 
                965                 970                 975     


Leu Asn Met Phe Ala Asn Lys Gln Leu Glu Leu Pro Arg Gly Trp Glu 
            980                 985                 990         


Met Lys His Asp His Gln Gly Lys  Ala Phe Phe Val Asp  His Asn Ser 
        995                 1000                 1005             


Arg Thr  Thr Thr Phe Ile Asp  Pro Arg Leu Pro Leu  Gln Ser Ser 
    1010                 1015                 1020             


Arg Pro  Thr Ser Ala Leu Val  His Arg Gln His Leu  Thr Arg Gln 
    1025                 1030                 1035             


Arg Ser  His Ser Ala Gly Glu  Val Gly Glu Asp Ser  Arg His Ala 
    1040                 1045                 1050             


Gly Pro  Pro Val Leu Pro Arg  Pro Ser Ser Thr Phe  Asn Thr Val 
    1055                 1060                 1065             


Ser Arg  Pro Gln Tyr Gln Asp  Met Val Pro Val Ala  Tyr Asn Asp 
    1070                 1075                 1080             


Lys Ile  Val Ala Phe Leu Arg  Gln Pro Asn Ile Phe  Glu Ile Leu 
    1085                 1090                 1095             


Gln Glu  Arg Gln Pro Asp Leu  Thr Arg Asn His Ser  Leu Arg Glu 
    1100                 1105                 1110             


Lys Ile  Gln Phe Ile Arg Thr  Glu Gly Thr Pro Gly  Leu Val Arg 
    1115                 1120                 1125             


Leu Ser  Ser Asp Ala Asp Leu  Val Met Leu Leu Ser  Leu Phe Glu 
    1130                 1135                 1140             


Glu Glu  Ile Met Ser Tyr Val  Pro Pro His Ala Leu  Leu His Pro 
    1145                 1150                 1155             


Ser Tyr  Cys Gln Ser Pro Arg  Gly Ser Pro Val Ser  Ser Pro Gln 
    1160                 1165                 1170             


Asn Ser  Pro Gly Thr Gln Arg  Ala Asn Ala Arg Ala  Pro Ala Pro 
    1175                 1180                 1185             


Tyr Lys  Arg Asp Phe Glu Ala  Lys Leu Arg Asn Phe  Tyr Arg Lys 
    1190                 1195                 1200             


Leu Glu  Thr Lys Gly Tyr Gly  Gln Gly Pro Gly Lys  Leu Lys Leu 
    1205                 1210                 1215             


Ile Ile  Arg Arg Asp His Leu  Leu Glu Asp Ala Phe  Asn Gln Ile 
    1220                 1225                 1230             


Met Gly  Tyr Ser Arg Lys Asp  Leu Gln Arg Asn Lys  Leu Tyr Val 
    1235                 1240                 1245             


Thr Phe  Val Gly Glu Glu Gly  Leu Asp Tyr Ser Gly  Pro Ser Arg 
    1250                 1255                 1260             


Glu Phe  Phe Phe Leu Val Ser  Arg Glu Leu Phe Asn  Pro Tyr Tyr 
    1265                 1270                 1275             


Gly Leu  Phe Glu Tyr Ser Ala  Asn Asp Thr Tyr Thr  Val Gln Ile 
    1280                 1285                 1290             


Ser Pro  Met Ser Ala Phe Val  Asp Asn His His Glu  Trp Phe Arg 
    1295                 1300                 1305             


Phe Ser  Gly Arg Ile Leu Gly  Leu Ala Leu Ile His  Gln Tyr Leu 
    1310                 1315                 1320             


Leu Asp  Ala Phe Phe Thr Arg  Pro Phe Tyr Lys Ala  Leu Leu Arg 
    1325                 1330                 1335             


Ile Leu  Cys Asp Leu Ser Asp  Leu Glu Tyr Leu Asp  Glu Glu Phe 
    1340                 1345                 1350             


His Gln  Ser Leu Gln Trp Met  Lys Asp Asn Asp Ile  His Asp Ile 
    1355                 1360                 1365             


Leu Asp  Leu Thr Phe Thr Val  Asn Glu Glu Val Phe  Gly Gln Ile 
    1370                 1375                 1380             


Thr Glu  Arg Glu Leu Lys Pro  Gly Gly Ala Asn Ile  Pro Val Thr 
    1385                 1390                 1395             


Glu Lys  Asn Lys Lys Glu Tyr  Ile Glu Arg Met Val  Lys Trp Arg 
    1400                 1405                 1410             


Ile Glu  Arg Gly Val Val Gln  Gln Thr Glu Ser Leu  Val Arg Gly 
    1415                 1420                 1425             


Phe Tyr  Glu Val Val Asp Ala  Arg Leu Val Ser Val  Phe Asp Ala 
    1430                 1435                 1440             


Arg Glu  Leu Glu Leu Val Ile  Ala Gly Thr Ala Glu  Ile Asp Leu 
    1445                 1450                 1455             


Ser Asp  Trp Arg Asn Asn Thr  Glu Tyr Arg Gly Gly  Tyr His Asp 
    1460                 1465                 1470             


Asn His  Ile Val Ile Arg Trp  Phe Trp Ala Ala Val  Glu Arg Phe 
    1475                 1480                 1485             


Asn Asn  Glu Gln Arg Leu Arg  Leu Leu Gln Phe Val  Thr Gly Thr 
    1490                 1495                 1500             


Ser Ser  Ile Pro Tyr Glu Gly  Phe Ala Ser Leu Arg  Gly Ser Asn 
    1505                 1510                 1515             


Gly Pro  Arg Arg Phe Cys Val  Glu Lys Trp Gly Lys  Ile Thr Ala 
    1520                 1525                 1530             


Leu Pro  Arg Ala His Thr Cys  Phe Asn Arg Leu Asp  Leu Pro Pro 
    1535                 1540                 1545             


Tyr Pro  Ser Phe Ser Met Leu  Tyr Glu Lys Leu Leu  Thr Ala Val 
    1550                 1555                 1560             


Glu Glu  Thr Ser Thr Phe Gly  Leu Glu 
    1565                 1570         

<210>  1500
<211>  6926
<212>  DNA
<213>  Homo sapiens

<400>  1500
atttgagcat cagttgaggg agaggacgct tcatttcctt tttggttggg aatgtgccgt     60

gaacatcctc tgctggagct tggggcctgg agcaaactgg ggctgcagat ttagacgtag    120

acgtttccga ggacgcgaga ctgcagagct ttgtaggcag ccaatcccag agaagcagac    180

gggatggcta gttcagcccg ggagcacctg ctttttgtga ggcgtcgaaa tccccagatg    240

cggtacacat tgagcccaga gaacctccag agccttgccg cccagagctc catgccagag    300

aacatgaccc tgcagcgggc caacagcgac accgacctgg tgacttctga gagccgctcc    360

agcttaactg ccagcatgta cgagtacacg ctggggcaag cccagaacct cattatcttc    420

tgggacatta aagaggaggt ggaccccagt gattggattg gactttatca tatagatgag    480

aattctccag ccaacttctg ggattctaag aacaggggtg tgactggaac acaaaaaggg    540

caaattgtat ggagaattga gcctgggccc tatttcatgg aaccggagat aaaaatctgt    600

tttaaatatt accacggcat tagtggagcc ctgcgagcca cgaccccctg catcaccgtg    660

aagaacccag ctgtgatgat gggggcagaa ggcatggagg gaggtgcttc aggaaacctg    720

cattctcgaa aacttgttag ctttacattg tcagatctta gggcagttgg gctaaagaaa    780

gggatgttct tcaatcctga cccttatctt aagatgtcaa ttcagccagg aaagaagagc    840

agtttcccca cctgtgccca ccacgggcag gagagacggt ctactatcat cagtaacacc    900

accaatccaa tttggcaccg agagaaatat tccttttttg cacttcttac tgatgtctta    960

gaaattgaaa ttaaagacaa atttgccaag agccgtccca tcatcaagcg ttttctgggg   1020

aaactaacca ttccagtcca gaggctgctg gagcgacaag ccatcggtga tcaaatgctc   1080

agctacaacc ttggcagaag gctcccagct gaccacgtga gtgggtacct ccagtttaaa   1140

gtggaggtta cgtcttctgt tcatgaagat gcctctccag aagctgttgg cacaatactt   1200

ggagtcaatt ctgtgaatgg agacttaggt agcccttccg atgacgagga catgccaggg   1260

agccatcacg acagccaggt gtgctctaat gggccagttt ctgaggacag tgctgccgat   1320

ggaaccccca agcattcatt caggactagc tccactctgg aaatagacac agaggaatta   1380

acctctacgt cttcaaggac ctcacctccc agaggacgtc aggattcact caatgattac   1440

ttagatgcta tcgaacacaa tggccactcc aggccgggga cagcgacctg ctctgagagg   1500

tccatgggtg cctctccgaa actgaggagt agttttccca ctgacacaag actcaatgcc   1560

atgcttcata ttgattcaga tgaagaagat cacgagttcc agcaagacct gggttaccca   1620

tcttccttgg aggaggaggg aggcctgatc atgtttagca gggcatccag agctgatgat   1680

ggaagcctga catctcagac aaagctggag gacaaccctg ttgagaatga ggaagcctcc   1740

acacacgaag ctgcttcctt tgaggataag ccagaaaatc ttccagagct tgcagagagc   1800

tccttacctg caggcccagc cccagaggaa ggtgaaggcg gcccagagcc tcaacccagt   1860

gctgaccagg gcagtgctga actgtgtggc tctcaagagg tagatcagcc cacaagtggc   1920

gcagacacag ggacttccga tgcatcagga ggaagccgaa gagccgtcag tgagaccgag   1980

tctctcgatc agggctctga gccttcccag gtgtcctctg aaacagaacc cagtgatcct   2040

gccaggacag agagtgtgag cgaagccagc accaggcctg agggagagag tgacctggaa   2100

tgcgctgaca gctcctgcaa tgagagtgtg accacgcagc tgtcctctgt ggacacacgg   2160

tgctcctctc ttgagagcgc acggtttcct gaaaccccag ccttttcttc tcaggaggag   2220

gaagacggag cctgtgcagc agagcccacc agcagtggcc ctgccgaagg gtcgcaggaa   2280

tccgtgtgca ctgctggttc tttacctgtg gtacaggtgc ccagtgggga ggatgaaggg   2340

ccaggggcag aatcggccac tgtacctgac caggaggagc tgggggaggt ctggcagcgg   2400

agggggagcc tggagggagc tgcagctgct gccgagagcc caccgcaaga agaaggcagt   2460

gctggggagg cccaaggcac ctgtgaaggg gcaactgccc aggaggaggg cgctactgga   2520

ggttctcaag ccaacggcca ccagccactg cgatcactac cttcagtgcg ccaggatgtt   2580

agccggtacc agagggtgga cgaggctctc ccaccaaact gggaggcacg cattgacagc   2640

cacggcagga tcttctacgt ggatcacgta aacagaacca cgacgtggca gcgaccgaca   2700

gctcccccag ccccgcaggt gctgcagaga tctaactcca tacagcaaat ggagcagctg   2760

aaccggcgat atcagagtat ccgcagaacc atgaccaatg agaggcctga ggaaaatacc   2820

aatgctattg atggggcagg ggaggaagct gactttcacc aagccagtgc agatttccga   2880

cgggagaaca tcctgcctca ctctacctcc agatccagga tcacgttgct gttacagtct   2940

ccccccgtga agttcctcat cagcccagag ttcttcaccg tgctgcattc taaccctagt   3000

gcctaccgca tgtttacaaa caacacgtgt ttgaagcaca tgatcaccaa agtccggagg   3060

gacacccacc actttgaacg ctaccagcat aaccgcgacc ttgtgggatt cctcaacatg   3120

ttcgcgaaca aacagctaga gctgccgcgg ggatgggaaa tgaaacatga tcaccagggc   3180

aaggcattct ttgtggacca caactcccgc accaccactt tcattgatcc ccggctccca   3240

cttcagagca gtagacccac aagtgcgctg gttcatcggc aacacctgac aaggcaacgc   3300

agccacagtg cgggtgaggt aggagaagat tctcgacatg caggaccacc agttcttccc   3360

aggccatcca gtacattcaa tacagtcagt aggccacagt accaggacat ggttccagtg   3420

gcttacaatg acaagattgt tgcatttcta cgtcaaccca atatctttga aattctacag   3480

gagcgtcaac ctgatcttac caggaatcac tcactcaggg agaagatcca atttatccga   3540

actgaaggga ctccaggatt ggtgcgcctt tcaagcgatg cagaccttgt tatgttgctg   3600

agcttatttg aagaagagat aatgtcgtat gtgcctccac atgccttact ccaccccagc   3660

tactgtcagt ccccacgtgg ctctcccgtg tcatctcctc agaactcgcc aggtacccag   3720

cgtgccaatg cccgggctcc agccccttac aagcgggatt tcgaagccaa actgaggaac   3780

ttttacagga agttagagac taaaggatat ggacaaggcc cagggaagtt aaagttaatt   3840

atccgaagag atcacttact agaagatgct tttaatcaga ttatgggcta ctccagaaaa   3900

gacctgcaga gaaataagct atatgtcacc ttcgttgggg aggaagggct ggattacagt   3960

gggccttcta gagagttttt cttcctggta tccagagaac tctttaaccc atattatggc   4020

ttatttgaat attcagccaa tgacacatac acagtacaaa taagtcctat gtctgctttt   4080

gtagacaatc accatgaatg gttccgattc agtggtagga tccttggtct tgcactaata   4140

caccagtatt tgttggatgc cttcttcaca cggccctttt ataaggctct tctcagaatt   4200

ctatgtgacc tgagtgacct agaatacctt gatgaagagt tccatcagag cctgcagtgg   4260

atgaaagaca atgatatcca tgacatccta gacctcacgt tcactgtgaa cgaagaagta   4320

tttgggcaga taactgaacg agaattaaag ccagggggtg ccaatatccc agttacagag   4380

aagaacaaga aggagtacat cgagaggatg gtgaagtgga ggattgagag gggtgttgta   4440

cagcaaacag agagcttagt gcgtggcttc tatgaggtgg tggatgccag gctggtatct   4500

gtttttgatg caagagaact ggaattggtc atcgcaggca cagctgaaat agacctaagt   4560

gattggagaa acaacacaga atatagagga ggataccatg acaatcatat tgtaattcgg   4620

tggttctggg ctgcagtgga aagattcaac aatgaacaac gactaaggtt gttacagttt   4680

gttacaggca catccagcat tccctatgaa ggatttgctt cactccgagg gagtaacggc   4740

ccaagaagat tctgtgtgga gaaatggggg aaaatcactg ctcttcccag agcgcataca   4800

tgttttaacc gtctggatct gcctccctac ccatcctttt ccatgcttta tgaaaaactg   4860

ttgacagcag ttgaagaaac cagtactttt ggacttgagt gacctggaag ctgaatgccc   4920

atctctgtgg acaggcaggt tcagaagctg ccttctagaa gaatgattga acattggaag   4980

tttcaagagg atgcttcctt taggataaag ctatgtgctg ttgttttcca ggaacaagtg   5040

ctctgtcaca tttggggact ggagatgagt cctcttggaa ggatttgggt gagcttgatg   5100

cccagggaac aacccaaccg tctttcaatc aacagttctt gactgccaaa ctttttccat   5160

ttgttatgtt ccaagacaaa gatgaaccca tacatgatca gctccacggt aatttttagg   5220

gactcaggag aatcttgaaa cttacccttg aacgtggttc aagccaaact ggcagcattt   5280

ggcccaatct ccaaattaga gcaagttaaa taatataata aaagtaaata tatttcctga   5340

aagtacattc atttaagccc taagttataa cagaatattc atttcttgct tatgagtgcc   5400

tgcatggtgt gcaccatagg tttccgcttt catgggacat gagtgaaaat gaaaccaagt   5460

caatatgagg tacctttaca gatttgcaat aagatggtct gtgacaatgt atatgcaagt   5520

ggtatgtgtg taattatggc taaagacaaa ccattattca gtgaattact aatgacagat   5580

tttatgcttt ataatgcatg aaaacaattt taaaataact agcaattaat cacagcatat   5640

caggaaaaag tacacagtga gttctgttta ttttttgtag gttcattatg tttatgttct   5700

ttaagatgta tataagaacc tacctatcat gctgtatgta tcactcattc cattttcatg   5760

ttccatgcat actcgggcat catgctaata tgtatccttt taagcactct caaggaaaca   5820

aaagggcctt ttatttttat aaaggtaaaa aaaattcccc aaatattttg cactgaatgt   5880

accaaaggtg aagggacatt acaatatgac taacagcaac tccatcactt gagaagtata   5940

atagaaaata gcttctaaat caaacttcct tcacagtgcc gtgtctacca ctacaaggac   6000

tgtgcatcta agtaataatt ttttaagatt cactatatgt gatagtatga tatgcattta   6060

tttaaaatgc attagactct cttccatcca tcaaatactt tacaggatgg catttaatac   6120

agatatttcg tatttccccc actgcttttt atttgtacag catcattaaa cactaagctc   6180

agttaaggag ccatcagcaa cactgaagag atcagtagta agaattccat tttccctcat   6240

cagtgaagac accacaaatt gaaactcaga actatatttc taagcctgca ttttcactga   6300

tgcataattt tcttattaat attaagagac agtttttcta tggcatctcc aaaactgcat   6360

gacatcacta gtcttacttc tgcttaattt tatgagaagg tattcttcat tttaattgct   6420

tttgggatta ctccacatct ttgtttattt cttgactaat cagattttca atagagtgaa   6480

gttaaattgg gggtcataaa agcattggat tgacatatgg tttgccagcc tatgggttta   6540

caggcattgc ccaaacattt ctttgagatc tatatttata agcagccatg gaattcctat   6600

tatgggatgt tggcaatctt acattttata gaggtcatat gcatagtttt cataggtgtt   6660

ttgtaagaac tgattgctct cctgtgagtt aagctatgtt tactactggg accctcaaga   6720

ggaataccac ttatgttaca ctcctgcact aaaggcacgt actgcagtgt gaagaaatgt   6780

tctgaaaaag ggttatagaa atctggaaat aagaaaggaa gagctctctg tattctataa   6840

ttggaagaga aaaaaagaaa aacttttaac tggaaatgtt agtttgtact tattgatcat   6900

gaatacaagt atatatttaa ttttgc                                        6926


<210>  1501
<211>  1572
<212>  PRT
<213>  Homo sapiens

<400>  1501


Met Ala Ser Ser Ala Arg Glu His Leu Leu Phe Val Arg Arg Arg Asn 
1               5                   10                  15      


Pro Gln Met Arg Tyr Thr Leu Ser Pro Glu Asn Leu Gln Ser Leu Ala 
            20                  25                  30          


Ala Gln Ser Ser Met Pro Glu Asn Met Thr Leu Gln Arg Ala Asn Ser 
        35                  40                  45              


Asp Thr Asp Leu Val Thr Ser Glu Ser Arg Ser Ser Leu Thr Ala Ser 
    50                  55                  60                  


Met Tyr Glu Tyr Thr Leu Gly Gln Ala Gln Asn Leu Ile Ile Phe Trp 
65                  70                  75                  80  


Asp Ile Lys Glu Glu Val Asp Pro Ser Asp Trp Ile Gly Leu Tyr His 
                85                  90                  95      


Ile Asp Glu Asn Ser Pro Ala Asn Phe Trp Asp Ser Lys Asn Arg Gly 
            100                 105                 110         


Val Thr Gly Thr Gln Lys Gly Gln Ile Val Trp Arg Ile Glu Pro Gly 
        115                 120                 125             


Pro Tyr Phe Met Glu Pro Glu Ile Lys Ile Cys Phe Lys Tyr Tyr His 
    130                 135                 140                 


Gly Ile Ser Gly Ala Leu Arg Ala Thr Thr Pro Cys Ile Thr Val Lys 
145                 150                 155                 160 


Asn Pro Ala Val Met Met Gly Ala Glu Gly Met Glu Gly Gly Ala Ser 
                165                 170                 175     


Gly Asn Leu His Ser Arg Lys Leu Val Ser Phe Thr Leu Ser Asp Leu 
            180                 185                 190         


Arg Ala Val Gly Leu Lys Lys Gly Met Phe Phe Asn Pro Asp Pro Tyr 
        195                 200                 205             


Leu Lys Met Ser Ile Gln Pro Gly Lys Lys Ser Ser Phe Pro Thr Cys 
    210                 215                 220                 


Ala His His Gly Gln Glu Arg Arg Ser Thr Ile Ile Ser Asn Thr Thr 
225                 230                 235                 240 


Asn Pro Ile Trp His Arg Glu Lys Tyr Ser Phe Phe Ala Leu Leu Thr 
                245                 250                 255     


Asp Val Leu Glu Ile Glu Ile Lys Asp Lys Phe Ala Lys Ser Arg Pro 
            260                 265                 270         


Ile Ile Lys Arg Phe Leu Gly Lys Leu Thr Ile Pro Val Gln Arg Leu 
        275                 280                 285             


Leu Glu Arg Gln Ala Ile Gly Asp Gln Met Leu Ser Tyr Asn Leu Gly 
    290                 295                 300                 


Arg Arg Leu Pro Ala Asp His Val Ser Gly Tyr Leu Gln Phe Lys Val 
305                 310                 315                 320 


Glu Val Thr Ser Ser Val His Glu Asp Ala Ser Pro Glu Ala Val Gly 
                325                 330                 335     


Thr Ile Leu Gly Val Asn Ser Val Asn Gly Asp Leu Gly Ser Pro Ser 
            340                 345                 350         


Asp Asp Glu Asp Met Pro Gly Ser His His Asp Ser Gln Val Cys Ser 
        355                 360                 365             


Asn Gly Pro Val Ser Glu Asp Ser Ala Ala Asp Gly Thr Pro Lys His 
    370                 375                 380                 


Ser Phe Arg Thr Ser Ser Thr Leu Glu Ile Asp Thr Glu Glu Leu Thr 
385                 390                 395                 400 


Ser Thr Ser Ser Arg Thr Ser Pro Pro Arg Gly Arg Gln Asp Ser Leu 
                405                 410                 415     


Asn Asp Tyr Leu Asp Ala Ile Glu His Asn Gly His Ser Arg Pro Gly 
            420                 425                 430         


Thr Ala Thr Cys Ser Glu Arg Ser Met Gly Ala Ser Pro Lys Leu Arg 
        435                 440                 445             


Ser Ser Phe Pro Thr Asp Thr Arg Leu Asn Ala Met Leu His Ile Asp 
    450                 455                 460                 


Ser Asp Glu Glu Asp His Glu Phe Gln Gln Asp Leu Gly Tyr Pro Ser 
465                 470                 475                 480 


Ser Leu Glu Glu Glu Gly Gly Leu Ile Met Phe Ser Arg Ala Ser Arg 
                485                 490                 495     


Ala Asp Asp Gly Ser Leu Thr Ser Gln Thr Lys Leu Glu Asp Asn Pro 
            500                 505                 510         


Val Glu Asn Glu Glu Ala Ser Thr His Glu Ala Ala Ser Phe Glu Asp 
        515                 520                 525             


Lys Pro Glu Asn Leu Pro Glu Leu Ala Glu Ser Ser Leu Pro Ala Gly 
    530                 535                 540                 


Pro Ala Pro Glu Glu Gly Glu Gly Gly Pro Glu Pro Gln Pro Ser Ala 
545                 550                 555                 560 


Asp Gln Gly Ser Ala Glu Leu Cys Gly Ser Gln Glu Val Asp Gln Pro 
                565                 570                 575     


Thr Ser Gly Ala Asp Thr Gly Thr Ser Asp Ala Ser Gly Gly Ser Arg 
            580                 585                 590         


Arg Ala Val Ser Glu Thr Glu Ser Leu Asp Gln Gly Ser Glu Pro Ser 
        595                 600                 605             


Gln Val Ser Ser Glu Thr Glu Pro Ser Asp Pro Ala Arg Thr Glu Ser 
    610                 615                 620                 


Val Ser Glu Ala Ser Thr Arg Pro Glu Gly Glu Ser Asp Leu Glu Cys 
625                 630                 635                 640 


Ala Asp Ser Ser Cys Asn Glu Ser Val Thr Thr Gln Leu Ser Ser Val 
                645                 650                 655     


Asp Thr Arg Cys Ser Ser Leu Glu Ser Ala Arg Phe Pro Glu Thr Pro 
            660                 665                 670         


Ala Phe Ser Ser Gln Glu Glu Glu Asp Gly Ala Cys Ala Ala Glu Pro 
        675                 680                 685             


Thr Ser Ser Gly Pro Ala Glu Gly Ser Gln Glu Ser Val Cys Thr Ala 
    690                 695                 700                 


Gly Ser Leu Pro Val Val Gln Val Pro Ser Gly Glu Asp Glu Gly Pro 
705                 710                 715                 720 


Gly Ala Glu Ser Ala Thr Val Pro Asp Gln Glu Glu Leu Gly Glu Val 
                725                 730                 735     


Trp Gln Arg Arg Gly Ser Leu Glu Gly Ala Ala Ala Ala Ala Glu Ser 
            740                 745                 750         


Pro Pro Gln Glu Glu Gly Ser Ala Gly Glu Ala Gln Gly Thr Cys Glu 
        755                 760                 765             


Gly Ala Thr Ala Gln Glu Glu Gly Ala Thr Gly Gly Ser Gln Ala Asn 
    770                 775                 780                 


Gly His Gln Pro Leu Arg Ser Leu Pro Ser Val Arg Gln Asp Val Ser 
785                 790                 795                 800 


Arg Tyr Gln Arg Val Asp Glu Ala Leu Pro Pro Asn Trp Glu Ala Arg 
                805                 810                 815     


Ile Asp Ser His Gly Arg Ile Phe Tyr Val Asp His Val Asn Arg Thr 
            820                 825                 830         


Thr Thr Trp Gln Arg Pro Thr Ala Pro Pro Ala Pro Gln Val Leu Gln 
        835                 840                 845             


Arg Ser Asn Ser Ile Gln Gln Met Glu Gln Leu Asn Arg Arg Tyr Gln 
    850                 855                 860                 


Ser Ile Arg Arg Thr Met Thr Asn Glu Arg Pro Glu Glu Asn Thr Asn 
865                 870                 875                 880 


Ala Ile Asp Gly Ala Gly Glu Glu Ala Asp Phe His Gln Ala Ser Ala 
                885                 890                 895     


Asp Phe Arg Arg Glu Asn Ile Leu Pro His Ser Thr Ser Arg Ser Arg 
            900                 905                 910         


Ile Thr Leu Leu Leu Gln Ser Pro Pro Val Lys Phe Leu Ile Ser Pro 
        915                 920                 925             


Glu Phe Phe Thr Val Leu His Ser Asn Pro Ser Ala Tyr Arg Met Phe 
    930                 935                 940                 


Thr Asn Asn Thr Cys Leu Lys His Met Ile Thr Lys Val Arg Arg Asp 
945                 950                 955                 960 


Thr His His Phe Glu Arg Tyr Gln His Asn Arg Asp Leu Val Gly Phe 
                965                 970                 975     


Leu Asn Met Phe Ala Asn Lys Gln Leu Glu Leu Pro Arg Gly Trp Glu 
            980                 985                 990         


Met Lys His Asp His Gln Gly Lys  Ala Phe Phe Val Asp  His Asn Ser 
        995                 1000                 1005             


Arg Thr  Thr Thr Phe Ile Asp  Pro Arg Leu Pro Leu  Gln Ser Ser 
    1010                 1015                 1020             


Arg Pro  Thr Ser Ala Leu Val  His Arg Gln His Leu  Thr Arg Gln 
    1025                 1030                 1035             


Arg Ser  His Ser Ala Gly Glu  Val Gly Glu Asp Ser  Arg His Ala 
    1040                 1045                 1050             


Gly Pro  Pro Val Leu Pro Arg  Pro Ser Ser Thr Phe  Asn Thr Val 
    1055                 1060                 1065             


Ser Arg  Pro Gln Tyr Gln Asp  Met Val Pro Val Ala  Tyr Asn Asp 
    1070                 1075                 1080             


Lys Ile  Val Ala Phe Leu Arg  Gln Pro Asn Ile Phe  Glu Ile Leu 
    1085                 1090                 1095             


Gln Glu  Arg Gln Pro Asp Leu  Thr Arg Asn His Ser  Leu Arg Glu 
    1100                 1105                 1110             


Lys Ile  Gln Phe Ile Arg Thr  Glu Gly Thr Pro Gly  Leu Val Arg 
    1115                 1120                 1125             


Leu Ser  Ser Asp Ala Asp Leu  Val Met Leu Leu Ser  Leu Phe Glu 
    1130                 1135                 1140             


Glu Glu  Ile Met Ser Tyr Val  Pro Pro His Ala Leu  Leu His Pro 
    1145                 1150                 1155             


Ser Tyr  Cys Gln Ser Pro Arg  Gly Ser Pro Val Ser  Ser Pro Gln 
    1160                 1165                 1170             


Asn Ser  Pro Gly Thr Gln Arg  Ala Asn Ala Arg Ala  Pro Ala Pro 
    1175                 1180                 1185             


Tyr Lys  Arg Asp Phe Glu Ala  Lys Leu Arg Asn Phe  Tyr Arg Lys 
    1190                 1195                 1200             


Leu Glu  Thr Lys Gly Tyr Gly  Gln Gly Pro Gly Lys  Leu Lys Leu 
    1205                 1210                 1215             


Ile Ile  Arg Arg Asp His Leu  Leu Glu Asp Ala Phe  Asn Gln Ile 
    1220                 1225                 1230             


Met Gly  Tyr Ser Arg Lys Asp  Leu Gln Arg Asn Lys  Leu Tyr Val 
    1235                 1240                 1245             


Thr Phe  Val Gly Glu Glu Gly  Leu Asp Tyr Ser Gly  Pro Ser Arg 
    1250                 1255                 1260             


Glu Phe  Phe Phe Leu Val Ser  Arg Glu Leu Phe Asn  Pro Tyr Tyr 
    1265                 1270                 1275             


Gly Leu  Phe Glu Tyr Ser Ala  Asn Asp Thr Tyr Thr  Val Gln Ile 
    1280                 1285                 1290             


Ser Pro  Met Ser Ala Phe Val  Asp Asn His His Glu  Trp Phe Arg 
    1295                 1300                 1305             


Phe Ser  Gly Arg Ile Leu Gly  Leu Ala Leu Ile His  Gln Tyr Leu 
    1310                 1315                 1320             


Leu Asp  Ala Phe Phe Thr Arg  Pro Phe Tyr Lys Ala  Leu Leu Arg 
    1325                 1330                 1335             


Ile Leu  Cys Asp Leu Ser Asp  Leu Glu Tyr Leu Asp  Glu Glu Phe 
    1340                 1345                 1350             


His Gln  Ser Leu Gln Trp Met  Lys Asp Asn Asp Ile  His Asp Ile 
    1355                 1360                 1365             


Leu Asp  Leu Thr Phe Thr Val  Asn Glu Glu Val Phe  Gly Gln Ile 
    1370                 1375                 1380             


Thr Glu  Arg Glu Leu Lys Pro  Gly Gly Ala Asn Ile  Pro Val Thr 
    1385                 1390                 1395             


Glu Lys  Asn Lys Lys Glu Tyr  Ile Glu Arg Met Val  Lys Trp Arg 
    1400                 1405                 1410             


Ile Glu  Arg Gly Val Val Gln  Gln Thr Glu Ser Leu  Val Arg Gly 
    1415                 1420                 1425             


Phe Tyr  Glu Val Val Asp Ala  Arg Leu Val Ser Val  Phe Asp Ala 
    1430                 1435                 1440             


Arg Glu  Leu Glu Leu Val Ile  Ala Gly Thr Ala Glu  Ile Asp Leu 
    1445                 1450                 1455             


Ser Asp  Trp Arg Asn Asn Thr  Glu Tyr Arg Gly Gly  Tyr His Asp 
    1460                 1465                 1470             


Asn His  Ile Val Ile Arg Trp  Phe Trp Ala Ala Val  Glu Arg Phe 
    1475                 1480                 1485             


Asn Asn  Glu Gln Arg Leu Arg  Leu Leu Gln Phe Val  Thr Gly Thr 
    1490                 1495                 1500             


Ser Ser  Ile Pro Tyr Glu Gly  Phe Ala Ser Leu Arg  Gly Ser Asn 
    1505                 1510                 1515             


Gly Pro  Arg Arg Phe Cys Val  Glu Lys Trp Gly Lys  Ile Thr Ala 
    1520                 1525                 1530             


Leu Pro  Arg Ala His Thr Cys  Phe Asn Arg Leu Asp  Leu Pro Pro 
    1535                 1540                 1545             


Tyr Pro  Ser Phe Ser Met Leu  Tyr Glu Lys Leu Leu  Thr Ala Val 
    1550                 1555                 1560             


Glu Glu  Thr Ser Thr Phe Gly  Leu Glu 
    1565                 1570         

<210>  1502
<211>  620
<212>  DNA
<213>  Homo sapiens

<400>  1502
gttcttccgc accttcctca gggaggtccc gctggccaag gtctggctgt ccctcctgtc     60

ctctgccccc gcctcccttc caccggtccc cgacgtgccg ccagctccca gcccagcgtc    120

ccgcagggcg gtgcgggcag atgccgccga agcgtctagc gggaagggcg ccggcgcggc    180

tggagctttg taggcagcca atcccagaga agcagacggg atggctagtt cagcccggga    240

gcacctgctt tttgtgaggc gtcgaaatcc ccagatgcgg tacacattga gcccagagaa    300

cctccagagc cttgccgccc agagctccat gccagagaac atgaccctgc agcgggccaa    360

cagcgacacc gacctggtga cttctgagag ccgctccagc ttaactgcca gcatgtacga    420

gtacacgctg gggcaagccc agaacctcat tatcttctgg gacattaaag aggaggtgga    480

ccccagtgat tggattggac tttatcatat agatgagaat tctccagcca acttctggga    540

ttctaagaac aggggtgtga ctggaacaca aaaagggcaa attgtatgga gaattgagcc    600

tgggccctat ttcatggaac                                                620


<210>  1503
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  1503


Met Ala Ser Ser Ala Arg Glu His Leu Leu Phe Val Arg Arg Arg Asn 
1               5                   10                  15      


Pro Gln Met Arg Tyr Thr Leu Ser Pro Glu Asn Leu Gln Ser Leu Ala 
            20                  25                  30          


Ala Gln Ser Ser Met Pro Glu Asn Met Thr Leu Gln Arg Ala Asn Ser 
        35                  40                  45              


Asp Thr Asp Leu Val Thr Ser Glu Ser Arg Ser Ser Leu Thr Ala Ser 
    50                  55                  60                  


Met Tyr Glu Tyr Thr Leu Gly Gln Ala Gln Asn Leu Ile Ile Phe Trp 
65                  70                  75                  80  


Asp Ile Lys Glu Glu Val Asp Pro Ser Asp Trp Ile Gly Leu Tyr His 
                85                  90                  95      


Ile Asp Glu Asn Ser Pro Ala Asn Phe Trp Asp Ser Lys Asn Arg Gly 
            100                 105                 110         


Val Thr Gly Thr Gln Lys Gly Gln Ile Val Trp Arg Ile Glu Pro Gly 
        115                 120                 125             


Pro Tyr Phe Met 
    130         

<210>  1504
<211>  574
<212>  DNA
<213>  Homo sapiens

<400>  1504
agatgccgcc gaagcgtcta gcgggaaggg cgccggcgcg gctggagggt ctcagtacag     60

ggtctctgag cctgttgccc aatctggagt gcgatggtgc agtcacatct cactgcagcc    120

ttgagctcct ggactcaagt gattctccac ctcagccttc ctcatagcta ggactacagc    180

tttgtaggca gccaatccca gagaagcaga cgggatggct agttcagccc gggagcacct    240

gctttttgtg aggcgtcgaa atccccagat gcggtacaca ttgagcccag agaacctcca    300

gagccttgcc gcccagagct ccatgccaga gaacatgacc ctgcagcggg ccaacagcga    360

caccgacctg gtgacttctg agagccgctc cagcttaact gccagcatgt acgagtacac    420

gctggggcaa gcccagaacc tcattatctt ctgggacatt aaagaggagg tggaccccag    480

tgattggatt ggactttatc atatagatga gaattctcca gccaacttct gggattctaa    540

gaacaggggt gtgactggaa cacaaaaagg gcaa                                574


<210>  1505
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  1505


Met Ala Ser Ser Ala Arg Glu His Leu Leu Phe Val Arg Arg Arg Asn 
1               5                   10                  15      


Pro Gln Met Arg Tyr Thr Leu Ser Pro Glu Asn Leu Gln Ser Leu Ala 
            20                  25                  30          


Ala Gln Ser Ser Met Pro Glu Asn Met Thr Leu Gln Arg Ala Asn Ser 
        35                  40                  45              


Asp Thr Asp Leu Val Thr Ser Glu Ser Arg Ser Ser Leu Thr Ala Ser 
    50                  55                  60                  


Met Tyr Glu Tyr Thr Leu Gly Gln Ala Gln Asn Leu Ile Ile Phe Trp 
65                  70                  75                  80  


Asp Ile Lys Glu Glu Val Asp Pro Ser Asp Trp Ile Gly Leu Tyr His 
                85                  90                  95      


Ile Asp Glu Asn Ser Pro Ala Asn Phe Trp Asp Ser Lys Asn Arg Gly 
            100                 105                 110         


Val Thr Gly Thr Gln Lys Gly 
        115                 

<210>  1506
<211>  3339
<212>  DNA
<213>  Homo sapiens

<400>  1506
gcggccgccc ctccccgatt cccgccacct gccgcctggc caggtggaag gggcgctgcc     60

gcgagcctcc gggcctcagg gtgttccggg gagcggcgcc ccgggtctct gggcccaccc    120

gccccgggcg tcctccgaga gtgggggctg cgcccgcggg gtcagacacc tgttcggccc    180

ggcccggcgt ggtcgccggg ggccaggatg aaagtgaccg tgtgcttcgg caggacgggc    240

atcgtggtgc cctgcaagga gggccagctg cgcgtcggcg agctcaccca gcaggcgctg    300

cagcggtacc tgaagacccg ggagaagggt cctggttact gggtgaagat tcatcactta    360

gaatatacag atggaggaat cctggatcca gatgatgtct tggcagatgt tgttgaagat    420

aaagacaagc tgattgctgt gtttgaagaa caagaaccac tccacaagat tgagagcccc    480

agtggaaacc ctgcagatcg gcagagccca gatgcttttg agacagaagt ggccgcccaa    540

ctggccgcat ttaagccaat tggtggggag attgaagtaa ccccttctgc tctaaaacta    600

ggcactccac tgctggtgag gagaagcagt gacccagtgc caggcccacc tgctgatacc    660

cagccaagcg cttcacaccc tggtggccag agtctgaaac tggttgttcc agattccacg    720

cagaacttgg aagacagaga agttttgaat ggtgtacaga cagaactact aacttcgcca    780

agaactaagg acacattgag tgatatgaca agaacagtgg agatttctgg ggaaggaggc    840

ccattgggaa tacatgtagt gcccttcttt tcatctctga gtggaaggat tctaggactc    900

ttcatccgag gcattgaaga caacagcagg tccaagcggg agggactatt tcacgaaaat    960

gaatgtattg taaaaatcaa caatgtggat ctcgtagaca aaacctttgc tcaggctcaa   1020

gatgtcttcc gccaggcaat gaaatctcca agtgtgctcc tccacgtgct tcctccacaa   1080

aaccgtgaac agtatgaaaa gtcagtcatt ggctctctta acatttttgg taataatgat   1140

ggcgttttga aaaccaaagt gccgcctcct gtccatggaa aatcgggact aaagacagca   1200

aatctcacag gaaccgatag tcctgaaaca gatgcatcag cttccctgca acaaaacaag   1260

agtccccgag taccaaggct gggaggaaaa ccatcctctc cctcactctc gcctctcatg   1320

ggatttggca gcaataaaaa tgcaaagaaa attaagattg acctaaagaa aggccctgaa   1380

ggacttggtt tcactgtggt taccagagac tcttccatac atggtcccgg tcccattttt   1440

gtaaaaaaca ttttaccaaa gggagcagca ataaaagatg gccgcctaca atcaggggac   1500

agaattttgg aggtaaatgg gagagatgtc accggacgaa cccaggaaga gcttgtggcc   1560

atgctcagga gcaccaagca gggggagaca gcatcgctgg tcattgcccg ccaagaagga   1620

cattttctgc cccgagagtt gaaaggagaa cctgactgct gtgcactctc tctggagaca   1680

agcgagcagc tcacctttga gatccccctg aatgattcag gttctgctgg cctcggggtg   1740

agcttaaaag ggaacaaatc cagagaaact ggaacagact tggggatttt tatcaaatcc   1800

atcattcatg gaggcgctgc ttttaaggat ggtcgtctgc gaatgaatga ccagctgatt   1860

gcagttaatg gggaatctct tttgggaaag tccaaccacg aagctatgga aacacttagg   1920

cggtcaatgt ccatggaggg aaacatccga gggatgatcc agttggtgat tctgaggagg   1980

ccagagagac caatggagga tcctgcagag tgtggggcat tttccaagcc atgctttgag   2040

aactgtcaaa atgctgtaac cacctctagg cgaaatgata atagtatcct gcatccactt   2100

ggcacttgca gtccacaaga caaacagaaa ggtctattgc tgcccaatga cggatgggcc   2160

gagagtgaag ttccaccttc tccaacacca cattctgctc tgggattggg cctcgaagat   2220

tacagccaca gctctggggt ggattcagca gtatattttc cagatcagca catcaacttc   2280

agatctgtga caccggccag gcagcctgaa tcaattaatt tgaaagcctc gaagagcatg   2340

gaccttgtgc cagatgaaag caaggttcac tcattggctg gacaaaaatc ggaatctcca   2400

agcaaagatt ttggtccaac tctgggtttg aaaaagtcca gctccttgga gagtctgcag   2460

actgcagtgg ccgaggtcag gaagaatgac cttccctttc acaggccccg gccgcacatg   2520

gttcgaggcc gaggctgcaa tgagagcttt agagcagcca ttgacaaatc ctacgatgga   2580

cctgaagaaa tagaagctga cggtctgtct gataagagct ctcactctgg ccaaggagct   2640

ctgaattgtg agtctgcccc tcaggggaat tcggagctag aggacatgga aaataaagcc   2700

aggaaagtca aaaaaacgaa agagaaggag aagaaaaagg aaaagggcaa attgaaagtc   2760

aaggagaaaa agcgcaaaga ggagaatgaa gatccagaaa ggaaaataaa gaagaagggc   2820

ttcggcgcca tgctgagagt ggccgtccta cgggtggaag cactgaccgt atccagaagt   2880

tgcggaaaga gtattatcag gctcggaggg aaggtttccc tttatatgaa gacgacgaag   2940

gaagagcaag gccatctgag tatgacctac tctgggtcca ggggaggacc cgcagatcct   3000

gtagactatc tgccagcagc acctcggggg ctctacaagg aaagggagct tccctattat   3060

ccaggggctc atcctatgca ccctcccaaa gggagctatc cccgccccac agagctcagg   3120

gtggcagatc tccggtatcc tcagcactac ccacccccgc cagctcccca gcacaaagga   3180

ccctttcgac aagacgttcc gccttcccct ccccagcacc aaagaatgcc agcctatcag   3240

gaaacaggca gaccagggcc ccgtgggggc agcccagacc agtaccctta ccgaacccag   3300

gattcccggc agaagaaccc catgactgca gccgtatag                          3339


<210>  1507
<211>  1043
<212>  PRT
<213>  Homo sapiens

<400>  1507


Met Lys Val Thr Val Cys Phe Gly Arg Thr Gly Ile Val Val Pro Cys 
1               5                   10                  15      


Lys Glu Gly Gln Leu Arg Val Gly Glu Leu Thr Gln Gln Ala Leu Gln 
            20                  25                  30          


Arg Tyr Leu Lys Thr Arg Glu Lys Gly Pro Gly Tyr Trp Val Lys Ile 
        35                  40                  45              


His His Leu Glu Tyr Thr Asp Gly Gly Ile Leu Asp Pro Asp Asp Val 
    50                  55                  60                  


Leu Ala Asp Val Val Glu Asp Lys Asp Lys Leu Ile Ala Val Phe Glu 
65                  70                  75                  80  


Glu Gln Glu Pro Leu His Lys Ile Glu Ser Pro Ser Gly Asn Pro Ala 
                85                  90                  95      


Asp Arg Gln Ser Pro Asp Ala Phe Glu Thr Glu Val Ala Ala Gln Leu 
            100                 105                 110         


Ala Ala Phe Lys Pro Ile Gly Gly Glu Ile Glu Val Thr Pro Ser Ala 
        115                 120                 125             


Leu Lys Leu Gly Thr Pro Leu Leu Val Arg Arg Ser Ser Asp Pro Val 
    130                 135                 140                 


Pro Gly Pro Pro Ala Asp Thr Gln Pro Ser Ala Ser His Pro Gly Gly 
145                 150                 155                 160 


Gln Ser Leu Lys Leu Val Val Pro Asp Ser Thr Gln Asn Leu Glu Asp 
                165                 170                 175     


Arg Glu Val Leu Asn Gly Val Gln Thr Glu Leu Leu Thr Ser Pro Arg 
            180                 185                 190         


Thr Lys Asp Thr Leu Ser Asp Met Thr Arg Thr Val Glu Ile Ser Gly 
        195                 200                 205             


Glu Gly Gly Pro Leu Gly Ile His Val Val Pro Phe Phe Ser Ser Leu 
    210                 215                 220                 


Ser Gly Arg Ile Leu Gly Leu Phe Ile Arg Gly Ile Glu Asp Asn Ser 
225                 230                 235                 240 


Arg Ser Lys Arg Glu Gly Leu Phe His Glu Asn Glu Cys Ile Val Lys 
                245                 250                 255     


Ile Asn Asn Val Asp Leu Val Asp Lys Thr Phe Ala Gln Ala Gln Asp 
            260                 265                 270         


Val Phe Arg Gln Ala Met Lys Ser Pro Ser Val Leu Leu His Val Leu 
        275                 280                 285             


Pro Pro Gln Asn Arg Glu Gln Tyr Glu Lys Ser Val Ile Gly Ser Leu 
    290                 295                 300                 


Asn Ile Phe Gly Asn Asn Asp Gly Val Leu Lys Thr Lys Val Pro Pro 
305                 310                 315                 320 


Pro Val His Gly Lys Ser Gly Leu Lys Thr Ala Asn Leu Thr Gly Thr 
                325                 330                 335     


Asp Ser Pro Glu Thr Asp Ala Ser Ala Ser Leu Gln Gln Asn Lys Ser 
            340                 345                 350         


Pro Arg Val Pro Arg Leu Gly Gly Lys Pro Ser Ser Pro Ser Leu Ser 
        355                 360                 365             


Pro Leu Met Gly Phe Gly Ser Asn Lys Asn Ala Lys Lys Ile Lys Ile 
    370                 375                 380                 


Asp Leu Lys Lys Gly Pro Glu Gly Leu Gly Phe Thr Val Val Thr Arg 
385                 390                 395                 400 


Asp Ser Ser Ile His Gly Pro Gly Pro Ile Phe Val Lys Asn Ile Leu 
                405                 410                 415     


Pro Lys Gly Ala Ala Ile Lys Asp Gly Arg Leu Gln Ser Gly Asp Arg 
            420                 425                 430         


Ile Leu Glu Val Asn Gly Arg Asp Val Thr Gly Arg Thr Gln Glu Glu 
        435                 440                 445             


Leu Val Ala Met Leu Arg Ser Thr Lys Gln Gly Glu Thr Ala Ser Leu 
    450                 455                 460                 


Val Ile Ala Arg Gln Glu Gly His Phe Leu Pro Arg Glu Leu Lys Gly 
465                 470                 475                 480 


Glu Pro Asp Cys Cys Ala Leu Ser Leu Glu Thr Ser Glu Gln Leu Thr 
                485                 490                 495     


Phe Glu Ile Pro Leu Asn Asp Ser Gly Ser Ala Gly Leu Gly Val Ser 
            500                 505                 510         


Leu Lys Gly Asn Lys Ser Arg Glu Thr Gly Thr Asp Leu Gly Ile Phe 
        515                 520                 525             


Ile Lys Ser Ile Ile His Gly Gly Ala Ala Phe Lys Asp Gly Arg Leu 
    530                 535                 540                 


Arg Met Asn Asp Gln Leu Ile Ala Val Asn Gly Glu Ser Leu Leu Gly 
545                 550                 555                 560 


Lys Ser Asn His Glu Ala Met Glu Thr Leu Arg Arg Ser Met Ser Met 
                565                 570                 575     


Glu Gly Asn Ile Arg Gly Met Ile Gln Leu Val Ile Leu Arg Arg Pro 
            580                 585                 590         


Glu Arg Pro Met Glu Asp Pro Ala Glu Cys Gly Ala Phe Ser Lys Pro 
        595                 600                 605             


Cys Phe Glu Asn Cys Gln Asn Ala Val Thr Thr Ser Arg Arg Asn Asp 
    610                 615                 620                 


Asn Ser Ile Leu His Pro Leu Gly Thr Cys Ser Pro Gln Asp Lys Gln 
625                 630                 635                 640 


Lys Gly Leu Leu Leu Pro Asn Asp Gly Trp Ala Glu Ser Glu Val Pro 
                645                 650                 655     


Pro Ser Pro Thr Pro His Ser Ala Leu Gly Leu Gly Leu Glu Asp Tyr 
            660                 665                 670         


Ser His Ser Ser Gly Val Asp Ser Ala Val Tyr Phe Pro Asp Gln His 
        675                 680                 685             


Ile Asn Phe Arg Ser Val Thr Pro Ala Arg Gln Pro Glu Ser Ile Asn 
    690                 695                 700                 


Leu Lys Ala Ser Lys Ser Met Asp Leu Val Pro Asp Glu Ser Lys Val 
705                 710                 715                 720 


His Ser Leu Ala Gly Gln Lys Ser Glu Ser Pro Ser Lys Asp Phe Gly 
                725                 730                 735     


Pro Thr Leu Gly Leu Lys Lys Ser Ser Ser Leu Glu Ser Leu Gln Thr 
            740                 745                 750         


Ala Val Ala Glu Val Arg Lys Asn Asp Leu Pro Phe His Arg Pro Arg 
        755                 760                 765             


Pro His Met Val Arg Gly Arg Gly Cys Asn Glu Ser Phe Arg Ala Ala 
    770                 775                 780                 


Ile Asp Lys Ser Tyr Asp Gly Pro Glu Glu Ile Glu Ala Asp Gly Leu 
785                 790                 795                 800 


Ser Asp Lys Ser Ser His Ser Gly Gln Gly Ala Leu Asn Cys Glu Ser 
                805                 810                 815     


Ala Pro Gln Gly Asn Ser Glu Leu Glu Asp Met Glu Asn Lys Ala Arg 
            820                 825                 830         


Lys Val Lys Lys Thr Lys Glu Lys Glu Lys Lys Lys Glu Lys Gly Lys 
        835                 840                 845             


Leu Lys Val Lys Glu Lys Lys Arg Lys Glu Glu Asn Glu Asp Pro Glu 
    850                 855                 860                 


Arg Lys Ile Lys Lys Lys Gly Phe Gly Ala Met Leu Arg Val Ala Val 
865                 870                 875                 880 


Leu Arg Val Glu Ala Leu Thr Val Ser Arg Ser Cys Gly Lys Ser Ile 
                885                 890                 895     


Ile Arg Leu Gly Gly Lys Val Ser Leu Tyr Met Lys Thr Thr Lys Glu 
            900                 905                 910         


Glu Gln Gly His Leu Ser Met Thr Tyr Ser Gly Ser Arg Gly Gly Pro 
        915                 920                 925             


Ala Asp Pro Val Asp Tyr Leu Pro Ala Ala Pro Arg Gly Leu Tyr Lys 
    930                 935                 940                 


Glu Arg Glu Leu Pro Tyr Tyr Pro Gly Ala His Pro Met His Pro Pro 
945                 950                 955                 960 


Lys Gly Ser Tyr Pro Arg Pro Thr Glu Leu Arg Val Ala Asp Leu Arg 
                965                 970                 975     


Tyr Pro Gln His Tyr Pro Pro Pro Pro Ala Pro Gln His Lys Gly Pro 
            980                 985                 990         


Phe Arg Gln Asp Val Pro Pro Ser  Pro Pro Gln His Gln  Arg Met Pro 
        995                 1000                 1005             


Ala Tyr  Gln Glu Thr Gly Arg  Pro Gly Pro Arg Gly  Gly Ser Pro 
    1010                 1015                 1020             


Asp Gln  Tyr Pro Tyr Arg Thr  Gln Asp Ser Arg Gln  Lys Asn Pro 
    1025                 1030                 1035             


Met Thr  Ala Ala Val 
    1040             

<210>  1508
<211>  3618
<212>  DNA
<213>  Homo sapiens

<400>  1508
gcggccgccc ctccccgatt cccgccacct gccgcctggc caggtggaag gggcgctgcc     60

gcgagcctcc gggcctcagg gtgttccggg gagcggcgcc ccgggtctct gggcccaccc    120

gccccgggcg tcctccgaga gtgggggctg cgcccgcggg gtcagacacc tgttcggccc    180

ggcccggcgt ggtcgccggg ggccaggatg aaagtgaccg tgtgcttcgg caggacgggc    240

atcgtggtgc cctgcaagga gggccagctg cgcgtcggcg agctcaccca gcaggcgctg    300

cagcggtacc tgaagacccg ggagaagggt cctggttact gggtgaagat tcatcactta    360

gaatatacag atggaggaat cctggatcca gatgatgtct tggcagatgt tgttgaagat    420

aaagacaagc tgattgctgt gtttgaagaa caagaaccac tccacaagat tgagagcccc    480

agtggaaacc ctgcagatcg gcagagccca gatgcttttg agacagaagt ggccgcccaa    540

ctggccgcat ttaagccaat tggtggggag attgaagtaa ccccttctgc tctaaaacta    600

ggcactccac tgctggtgag gagaagcagt gacccagtgc caggcccacc tgctgatacc    660

cagccaagcg cttcacaccc tggtggccag agtctgaaac tggttgttcc agattccacg    720

cagaacttgg aagacagaga agttttgaat ggtgtacaga cagaactact aacttcgcca    780

agaactaagg acacattgag tgatatgaca agaacagtgg agatttctgg ggaaggaggc    840

ccattgggaa tacatgtagt gcccttcttt tcatctctga gtggaaggat tctaggactc    900

ttcatccgag gcattgaaga caacagcagg tccaagcggg agggactatt tcacgaaaat    960

gaatgtattg taaaaatcaa caatgtggat ctcgtagaca aaacctttgc tcaggctcaa   1020

gatgtcttcc gccaggcaat gaaatctcca agtgtgctcc tccacgtgct tcctccacaa   1080

aaccgtgaac agtatgaaaa gtcagtcatt ggctctctta acatttttgg taataatgat   1140

ggcgttttga aaaccaaagt gccgcctcct gtccatggaa aatcgggact aaagacagca   1200

aatctcacag gaaccgatag tcctgaaaca gatgcatcag cttccctgca acaaaacaag   1260

agtccccgag taccaaggct gggaggaaaa ccatcctctc cctcactctc gcctctcatg   1320

ggatttggca gcaataaaaa tgcaaagaaa attaagattg acctaaagaa aggccctgaa   1380

ggacttggtt tcactgtggt taccagagac tcttccatac atggtcccgg tcccattttt   1440

gtaaaaaaca ttttaccaaa gggagcagca ataaaagatg gccgcctaca atcaggggac   1500

agaattttgg aggtaaatgg gagagatgtc accggacgaa cccaggaaga gcttgtggcc   1560

atgctcagga gcaccaagca gggggagaca gcatcgctgg tcattgcccg ccaagaagga   1620

cattttctgc cccgagagtt gaaaggagaa cctgactgct gtgcactctc tctggagaca   1680

agcgagcagc tcacctttga gatccccctg aatgattcag gttctgctgg cctcggggtg   1740

agcttaaaag ggaacaaatc cagagaaact ggaacagact tggggatttt tatcaaatcc   1800

atcattcatg gaggcgctgc ttttaaggat ggtcgtctgc gaatgaatga ccagctgatt   1860

gcagttaatg gggaatctct tttgggaaag tccaaccacg aagctatgga aacacttagg   1920

cggtcaatgt ccatggaggg aaacatccga gggatgatcc agttggtgat tctgaggagg   1980

ccagagagac caatggagga tcctgcagag tgtggggcat tttccaagcc atgctttgag   2040

aactgtcaaa atgctgtaac cacctctagg cgaaatgata atagtatcct gcatccactt   2100

ggcacttgca gtccacaaga caaacagaaa ggtctattgc tgcccaatga cggatgggcc   2160

gagagtgaag ttccaccttc tccaacacca cattctgctc tgggattggg cctcgaagat   2220

tacagccaca gctctggggt ggattcagca gtatattttc cagatcagca catcaacttc   2280

agatctgtga caccggccag gcagcctgaa tcaattaatt tgaaagcctc gaagagcatg   2340

gaccttgtgc cagatgaaag caaggttcac tcattggctg gacaaaaatc ggacggtctg   2400

tctgataaga gctctcactc tggccaagga gctctgaatt gtgagtctgc ccctcagggg   2460

aattcggagc tagaggacat ggaaaataaa gccaggaaag tcaaaaaaac gaaagagaag   2520

gagaagaaaa aggaaaaggg caaattgaaa gtcaaggaga aaaagcgcaa agaggagaat   2580

gaagatccag aaaggaaaat aaagaagaag ggcttcggcg ccatgctgag atttggaaag   2640

aagaaagagg ataagggtgg aaaggctgag cagaaaggta ctctgaaaca tggtggcctg   2700

agagaagaag agctggagaa aatgaaagaa gagcgtgaaa ggattggagc aaaacatcag   2760

gagctaaggg aaaagcaggc aagaggtctt cttgattatg ctactggtgc aattggatca   2820

gtgtatgata tggatgatga tgaaatggac cccaattatg ccagagtgaa ccactttcgg   2880

gaaccatgca catcagcaaa tgtctttaga tctccatctc cccctcgagc tggaccattt   2940

ggttaccctc gggatggcca tccactgtct ccagaaagag accacttaga gggtctctat   3000

gccaaggtca acaagccata ccatccactg gttccagctg acagtggccg tcctacgggt   3060

ggaagcactg accgtatcca gaagttgcgg aaagagtatt atcaggctcg gagggaaggt   3120

ttccctttat atgaagacga cgaaggaaga gcaaggccat ctgagtatga cctactctgg   3180

gtgcctggaa ggggtccaga tgggaatgca cacaacctcc gctttgaagg gatggagagg   3240

cagtacgcat ccttacccag gggaggaccc gcagatcctg tagactatct gccagcagca   3300

cctcgggggc tctacaagga aagggagctt ccctattatc caggggctca tcctatgcac   3360

cctcccaaag ggagctatcc ccgccccaca gagctcaggg tggcagatct ccggtatcct   3420

cagcactacc cacccccgcc agctccccag cacaaaggac cctttcgaca agacgttccg   3480

ccttcccctc cccagcacca aagaatgcca gcctatcagg aaacaggcag accagggccc   3540

cgtgggggca gcccagacca gtacccttac cgaacccagg attcccggca gaagaacccc   3600

atgactgcag ccgtatag                                                 3618


<210>  1509
<211>  1136
<212>  PRT
<213>  Homo sapiens

<400>  1509


Met Lys Val Thr Val Cys Phe Gly Arg Thr Gly Ile Val Val Pro Cys 
1               5                   10                  15      


Lys Glu Gly Gln Leu Arg Val Gly Glu Leu Thr Gln Gln Ala Leu Gln 
            20                  25                  30          


Arg Tyr Leu Lys Thr Arg Glu Lys Gly Pro Gly Tyr Trp Val Lys Ile 
        35                  40                  45              


His His Leu Glu Tyr Thr Asp Gly Gly Ile Leu Asp Pro Asp Asp Val 
    50                  55                  60                  


Leu Ala Asp Val Val Glu Asp Lys Asp Lys Leu Ile Ala Val Phe Glu 
65                  70                  75                  80  


Glu Gln Glu Pro Leu His Lys Ile Glu Ser Pro Ser Gly Asn Pro Ala 
                85                  90                  95      


Asp Arg Gln Ser Pro Asp Ala Phe Glu Thr Glu Val Ala Ala Gln Leu 
            100                 105                 110         


Ala Ala Phe Lys Pro Ile Gly Gly Glu Ile Glu Val Thr Pro Ser Ala 
        115                 120                 125             


Leu Lys Leu Gly Thr Pro Leu Leu Val Arg Arg Ser Ser Asp Pro Val 
    130                 135                 140                 


Pro Gly Pro Pro Ala Asp Thr Gln Pro Ser Ala Ser His Pro Gly Gly 
145                 150                 155                 160 


Gln Ser Leu Lys Leu Val Val Pro Asp Ser Thr Gln Asn Leu Glu Asp 
                165                 170                 175     


Arg Glu Val Leu Asn Gly Val Gln Thr Glu Leu Leu Thr Ser Pro Arg 
            180                 185                 190         


Thr Lys Asp Thr Leu Ser Asp Met Thr Arg Thr Val Glu Ile Ser Gly 
        195                 200                 205             


Glu Gly Gly Pro Leu Gly Ile His Val Val Pro Phe Phe Ser Ser Leu 
    210                 215                 220                 


Ser Gly Arg Ile Leu Gly Leu Phe Ile Arg Gly Ile Glu Asp Asn Ser 
225                 230                 235                 240 


Arg Ser Lys Arg Glu Gly Leu Phe His Glu Asn Glu Cys Ile Val Lys 
                245                 250                 255     


Ile Asn Asn Val Asp Leu Val Asp Lys Thr Phe Ala Gln Ala Gln Asp 
            260                 265                 270         


Val Phe Arg Gln Ala Met Lys Ser Pro Ser Val Leu Leu His Val Leu 
        275                 280                 285             


Pro Pro Gln Asn Arg Glu Gln Tyr Glu Lys Ser Val Ile Gly Ser Leu 
    290                 295                 300                 


Asn Ile Phe Gly Asn Asn Asp Gly Val Leu Lys Thr Lys Val Pro Pro 
305                 310                 315                 320 


Pro Val His Gly Lys Ser Gly Leu Lys Thr Ala Asn Leu Thr Gly Thr 
                325                 330                 335     


Asp Ser Pro Glu Thr Asp Ala Ser Ala Ser Leu Gln Gln Asn Lys Ser 
            340                 345                 350         


Pro Arg Val Pro Arg Leu Gly Gly Lys Pro Ser Ser Pro Ser Leu Ser 
        355                 360                 365             


Pro Leu Met Gly Phe Gly Ser Asn Lys Asn Ala Lys Lys Ile Lys Ile 
    370                 375                 380                 


Asp Leu Lys Lys Gly Pro Glu Gly Leu Gly Phe Thr Val Val Thr Arg 
385                 390                 395                 400 


Asp Ser Ser Ile His Gly Pro Gly Pro Ile Phe Val Lys Asn Ile Leu 
                405                 410                 415     


Pro Lys Gly Ala Ala Ile Lys Asp Gly Arg Leu Gln Ser Gly Asp Arg 
            420                 425                 430         


Ile Leu Glu Val Asn Gly Arg Asp Val Thr Gly Arg Thr Gln Glu Glu 
        435                 440                 445             


Leu Val Ala Met Leu Arg Ser Thr Lys Gln Gly Glu Thr Ala Ser Leu 
    450                 455                 460                 


Val Ile Ala Arg Gln Glu Gly His Phe Leu Pro Arg Glu Leu Lys Gly 
465                 470                 475                 480 


Glu Pro Asp Cys Cys Ala Leu Ser Leu Glu Thr Ser Glu Gln Leu Thr 
                485                 490                 495     


Phe Glu Ile Pro Leu Asn Asp Ser Gly Ser Ala Gly Leu Gly Val Ser 
            500                 505                 510         


Leu Lys Gly Asn Lys Ser Arg Glu Thr Gly Thr Asp Leu Gly Ile Phe 
        515                 520                 525             


Ile Lys Ser Ile Ile His Gly Gly Ala Ala Phe Lys Asp Gly Arg Leu 
    530                 535                 540                 


Arg Met Asn Asp Gln Leu Ile Ala Val Asn Gly Glu Ser Leu Leu Gly 
545                 550                 555                 560 


Lys Ser Asn His Glu Ala Met Glu Thr Leu Arg Arg Ser Met Ser Met 
                565                 570                 575     


Glu Gly Asn Ile Arg Gly Met Ile Gln Leu Val Ile Leu Arg Arg Pro 
            580                 585                 590         


Glu Arg Pro Met Glu Asp Pro Ala Glu Cys Gly Ala Phe Ser Lys Pro 
        595                 600                 605             


Cys Phe Glu Asn Cys Gln Asn Ala Val Thr Thr Ser Arg Arg Asn Asp 
    610                 615                 620                 


Asn Ser Ile Leu His Pro Leu Gly Thr Cys Ser Pro Gln Asp Lys Gln 
625                 630                 635                 640 


Lys Gly Leu Leu Leu Pro Asn Asp Gly Trp Ala Glu Ser Glu Val Pro 
                645                 650                 655     


Pro Ser Pro Thr Pro His Ser Ala Leu Gly Leu Gly Leu Glu Asp Tyr 
            660                 665                 670         


Ser His Ser Ser Gly Val Asp Ser Ala Val Tyr Phe Pro Asp Gln His 
        675                 680                 685             


Ile Asn Phe Arg Ser Val Thr Pro Ala Arg Gln Pro Glu Ser Ile Asn 
    690                 695                 700                 


Leu Lys Ala Ser Lys Ser Met Asp Leu Val Pro Asp Glu Ser Lys Val 
705                 710                 715                 720 


His Ser Leu Ala Gly Gln Lys Ser Asp Gly Leu Ser Asp Lys Ser Ser 
                725                 730                 735     


His Ser Gly Gln Gly Ala Leu Asn Cys Glu Ser Ala Pro Gln Gly Asn 
            740                 745                 750         


Ser Glu Leu Glu Asp Met Glu Asn Lys Ala Arg Lys Val Lys Lys Thr 
        755                 760                 765             


Lys Glu Lys Glu Lys Lys Lys Glu Lys Gly Lys Leu Lys Val Lys Glu 
    770                 775                 780                 


Lys Lys Arg Lys Glu Glu Asn Glu Asp Pro Glu Arg Lys Ile Lys Lys 
785                 790                 795                 800 


Lys Gly Phe Gly Ala Met Leu Arg Phe Gly Lys Lys Lys Glu Asp Lys 
                805                 810                 815     


Gly Gly Lys Ala Glu Gln Lys Gly Thr Leu Lys His Gly Gly Leu Arg 
            820                 825                 830         


Glu Glu Glu Leu Glu Lys Met Lys Glu Glu Arg Glu Arg Ile Gly Ala 
        835                 840                 845             


Lys His Gln Glu Leu Arg Glu Lys Gln Ala Arg Gly Leu Leu Asp Tyr 
    850                 855                 860                 


Ala Thr Gly Ala Ile Gly Ser Val Tyr Asp Met Asp Asp Asp Glu Met 
865                 870                 875                 880 


Asp Pro Asn Tyr Ala Arg Val Asn His Phe Arg Glu Pro Cys Thr Ser 
                885                 890                 895     


Ala Asn Val Phe Arg Ser Pro Ser Pro Pro Arg Ala Gly Pro Phe Gly 
            900                 905                 910         


Tyr Pro Arg Asp Gly His Pro Leu Ser Pro Glu Arg Asp His Leu Glu 
        915                 920                 925             


Gly Leu Tyr Ala Lys Val Asn Lys Pro Tyr His Pro Leu Val Pro Ala 
    930                 935                 940                 


Asp Ser Gly Arg Pro Thr Gly Gly Ser Thr Asp Arg Ile Gln Lys Leu 
945                 950                 955                 960 


Arg Lys Glu Tyr Tyr Gln Ala Arg Arg Glu Gly Phe Pro Leu Tyr Glu 
                965                 970                 975     


Asp Asp Glu Gly Arg Ala Arg Pro Ser Glu Tyr Asp Leu Leu Trp Val 
            980                 985                 990         


Pro Gly Arg Gly Pro Asp Gly Asn  Ala His Asn Leu Arg  Phe Glu Gly 
        995                 1000                 1005             


Met Glu  Arg Gln Tyr Ala Ser  Leu Pro Arg Gly Gly  Pro Ala Asp 
    1010                 1015                 1020             


Pro Val  Asp Tyr Leu Pro Ala  Ala Pro Arg Gly Leu  Tyr Lys Glu 
    1025                 1030                 1035             


Arg Glu  Leu Pro Tyr Tyr Pro  Gly Ala His Pro Met  His Pro Pro 
    1040                 1045                 1050             


Lys Gly  Ser Tyr Pro Arg Pro  Thr Glu Leu Arg Val  Ala Asp Leu 
    1055                 1060                 1065             


Arg Tyr  Pro Gln His Tyr Pro  Pro Pro Pro Ala Pro  Gln His Lys 
    1070                 1075                 1080             


Gly Pro  Phe Arg Gln Asp Val  Pro Pro Ser Pro Pro  Gln His Gln 
    1085                 1090                 1095             


Arg Met  Pro Ala Tyr Gln Glu  Thr Gly Arg Pro Gly  Pro Arg Gly 
    1100                 1105                 1110             


Gly Ser  Pro Asp Gln Tyr Pro  Tyr Arg Thr Gln Asp  Ser Arg Gln 
    1115                 1120                 1125             


Lys Asn  Pro Met Thr Ala Ala  Val 
    1130                 1135     

<210>  1510
<211>  3639
<212>  DNA
<213>  Homo sapiens

<400>  1510
gcggccgccc ctccccgatt cccgccacct gccgcctggc caggtggaag gggcgctgcc     60

gcgagcctcc gggcctcagg gtgttccggg gagcggcgcc ccgggtctct gggcccaccc    120

gccccgggcg tcctccgaga gtgggggctg cgcccgcggg gtcagacacc tgttcggccc    180

ggcccggcgt ggtcgccggg ggccaggatg aaagtgaccg tgtgcttcgg caggacgggc    240

atcgtggtgc cctgcaagga gggccagctg cgcgtcggcg agctcaccca gcaggcgctg    300

cagcggtacc tgaagacccg ggagaagggt cctggttact gggtgaagat tcatcactta    360

gaatatacag atggaggaat cctggatcca gatgatgtct tggcagatgt tgttgaagat    420

aaagacaagc tgattgctgt gtttgaagaa caagaaccac tccacaagat tgagagcccc    480

agtggaaacc ctgcagatcg gcagagccca gatgcttttg agacagaagt ggccgcccaa    540

ctggccgcat ttaagccaat tggtggggag attgaagtaa ccccttctgc tctaaaacta    600

ggcactccac tgctggtgag gagaagcagt gacccagtgc caggcccacc tgctgatacc    660

cagccaagcg cttcacaccc tggtggccag agtctgaaac tggttgttcc agattccacg    720

cagaacttgg aagacagaga agttttgaat ggtgtacaga cagaactact aacttcgcca    780

agaactaagg acacattgag tgatatgaca agaacagtgg agatttctgg ggaaggaggc    840

ccattgggaa tacatgtagt gcccttcttt tcatctctga gtggaaggat tctaggactc    900

ttcatccgag gcattgaaga caacagcagg tccaagcggg agggactatt tcacgaaaat    960

gaatgtattg taaaaatcaa caatgtggat ctcgtagaca aaacctttgc tcaggctcaa   1020

gatgtcttcc gccaggcaat gaaatctcca agtgtgctcc tccacgtgct tcctccacaa   1080

aaccgtgaac agtatgaaaa gtcagtcatt ggctctctta acatttttgg taataatgat   1140

ggcgttttga aaaccaaagt gccgcctcct gtccatggaa aatcgggact aaagacagca   1200

aatctcacag gaaccgatag tcctgaaaca gatgcatcag cttccctgca acaaaacaag   1260

agtccccgag taccaaggct gggaggaaaa ccatcctctc cctcactctc gcctctcatg   1320

ggatttggca gcaataaaaa tgcaaagaaa attaagattg acctaaagaa aggccctgaa   1380

ggacttggtt tcactgtggt taccagagac tcttccatac atggtcccgg tcccattttt   1440

gtaaaaaaca ttttaccaaa gggagcagca ataaaagatg gccgcctaca atcaggggac   1500

agaattttgg aggtaaatgg gagagatgtc accggacgaa cccaggaaga gcttgtggcc   1560

atgctcagga gcaccaagca gggggagaca gcatcgctgg tcattgcccg ccaagaagga   1620

cattttctgc cccgagagtt ggatggtcgt ctgcgaatga atgaccagct gattgcagtt   1680

aatggggaat ctcttttggg aaagtccaac cacgaagcta tggaaacact taggcggtca   1740

atgtccatgg agggaaacat ccgagggatg atccagttgg tgattctgag gaggccagag   1800

agaccaatgg aggatcctgc agagtgtggg gcattttcca agccatgctt tgagaactgt   1860

caaaatgctg taaccacctc taggcgaaat gataatagta tcctgcatcc acttggcact   1920

tgcagtccac aagacaaaca gaaaggtcta ttgctgccca atgacggatg ggccgagagt   1980

gaagttccac cttctccaac accacattct gctctgggat tgggcctcga agattacagc   2040

cacagctctg gggtggattc agcagtatat tttccagatc agcacatcaa cttcagatct   2100

gtgacaccgg ccaggcagcc tgaatcaatt aatttgaaag cctcgaagag catggacctt   2160

gtgccagatg aaagcaaggt tcactcattg gctggacaaa aatcggaatc tccaagcaaa   2220

gattttggtc caactctggg tttgaaaaag tccagctcct tggagagtct gcagactgca   2280

gtggccgagg tcaggaagaa tgaccttccc tttcacaggc cccggccgca catggttcga   2340

ggccgaggct gcaatgagag ctttagagca gccattgaca aatcctacga tggacctgaa   2400

gaaatagaag ctgacggtct gtctgataag agctctcact ctggccaagg agctctgaat   2460

tgtgagtctg cccctcaggg gaattcggag ctagaggaca tggaaaataa agccaggaaa   2520

gtcaaaaaaa cgaaagagaa ggagaagaaa aaggaaaagg gcaaattgaa agtcaaggag   2580

aaaaagcgca aagaggagaa tgaagatcca gaaaggaaaa taaagaagaa gggcttcggc   2640

gccatgctga gatttggaaa gaagaaagag gataagggtg gaaaggctga gcagaaaggt   2700

actctgaaac atggtggcct gagagaagaa gagctggaga aaatgaaaga agagcgtgaa   2760

aggattggag caaaacatca ggagctaagg gaaaagcagg caagaggtct tcttgattat   2820

gctactggtg caattggatc agtgtatgat atggatgatg atgaaatgga ccccaattat   2880

gccagagtga accactttcg ggaaccatgc acatcagcaa atgtctttag atctccatct   2940

ccccctcgag ctggaccatt tggttaccct cgggatggcc atccactgtc tccagaaaga   3000

gaccacttag agggtctcta tgccaaggtc aacaagccat accatccact ggttccagct   3060

gacagtggcc gtcctacggg tggaagcact gaccgtatcc agaagttgcg gaaagagtat   3120

tatcaggctc ggagggaagg tttcccttta tatgaagacg acgaaggaag agcaaggcca   3180

tctgagtatg acctactctg ggtgcctgga aggggtccag atgggaatgc acacaacctc   3240

cgctttgaag ggatggagag gcagtacgca tccttaccca ggggaggacc cgcagatcct   3300

gtagactatc tgccagcagc acctcggggg ctctacaagg aaagggagct tccctattat   3360

ccaggggctc atcctatgca ccctcccaaa gggagctatc cccgccccac agagctcagg   3420

gtggcagatc tccggtatcc tcagcactac ccacccccgc cagctcccca gcacaaagga   3480

ccctttcgac aagacgttcc gccttcccct ccccagcacc aaagaatgcc agcctatcag   3540

gaaacaggca gaccagggcc ccgtgggggc agcccagacc agtaccctta ccgaacccag   3600

gattcccggc agaagaaccc catgactgca gccgtatag                          3639


<210>  1511
<211>  1143
<212>  PRT
<213>  Homo sapiens

<400>  1511


Met Lys Val Thr Val Cys Phe Gly Arg Thr Gly Ile Val Val Pro Cys 
1               5                   10                  15      


Lys Glu Gly Gln Leu Arg Val Gly Glu Leu Thr Gln Gln Ala Leu Gln 
            20                  25                  30          


Arg Tyr Leu Lys Thr Arg Glu Lys Gly Pro Gly Tyr Trp Val Lys Ile 
        35                  40                  45              


His His Leu Glu Tyr Thr Asp Gly Gly Ile Leu Asp Pro Asp Asp Val 
    50                  55                  60                  


Leu Ala Asp Val Val Glu Asp Lys Asp Lys Leu Ile Ala Val Phe Glu 
65                  70                  75                  80  


Glu Gln Glu Pro Leu His Lys Ile Glu Ser Pro Ser Gly Asn Pro Ala 
                85                  90                  95      


Asp Arg Gln Ser Pro Asp Ala Phe Glu Thr Glu Val Ala Ala Gln Leu 
            100                 105                 110         


Ala Ala Phe Lys Pro Ile Gly Gly Glu Ile Glu Val Thr Pro Ser Ala 
        115                 120                 125             


Leu Lys Leu Gly Thr Pro Leu Leu Val Arg Arg Ser Ser Asp Pro Val 
    130                 135                 140                 


Pro Gly Pro Pro Ala Asp Thr Gln Pro Ser Ala Ser His Pro Gly Gly 
145                 150                 155                 160 


Gln Ser Leu Lys Leu Val Val Pro Asp Ser Thr Gln Asn Leu Glu Asp 
                165                 170                 175     


Arg Glu Val Leu Asn Gly Val Gln Thr Glu Leu Leu Thr Ser Pro Arg 
            180                 185                 190         


Thr Lys Asp Thr Leu Ser Asp Met Thr Arg Thr Val Glu Ile Ser Gly 
        195                 200                 205             


Glu Gly Gly Pro Leu Gly Ile His Val Val Pro Phe Phe Ser Ser Leu 
    210                 215                 220                 


Ser Gly Arg Ile Leu Gly Leu Phe Ile Arg Gly Ile Glu Asp Asn Ser 
225                 230                 235                 240 


Arg Ser Lys Arg Glu Gly Leu Phe His Glu Asn Glu Cys Ile Val Lys 
                245                 250                 255     


Ile Asn Asn Val Asp Leu Val Asp Lys Thr Phe Ala Gln Ala Gln Asp 
            260                 265                 270         


Val Phe Arg Gln Ala Met Lys Ser Pro Ser Val Leu Leu His Val Leu 
        275                 280                 285             


Pro Pro Gln Asn Arg Glu Gln Tyr Glu Lys Ser Val Ile Gly Ser Leu 
    290                 295                 300                 


Asn Ile Phe Gly Asn Asn Asp Gly Val Leu Lys Thr Lys Val Pro Pro 
305                 310                 315                 320 


Pro Val His Gly Lys Ser Gly Leu Lys Thr Ala Asn Leu Thr Gly Thr 
                325                 330                 335     


Asp Ser Pro Glu Thr Asp Ala Ser Ala Ser Leu Gln Gln Asn Lys Ser 
            340                 345                 350         


Pro Arg Val Pro Arg Leu Gly Gly Lys Pro Ser Ser Pro Ser Leu Ser 
        355                 360                 365             


Pro Leu Met Gly Phe Gly Ser Asn Lys Asn Ala Lys Lys Ile Lys Ile 
    370                 375                 380                 


Asp Leu Lys Lys Gly Pro Glu Gly Leu Gly Phe Thr Val Val Thr Arg 
385                 390                 395                 400 


Asp Ser Ser Ile His Gly Pro Gly Pro Ile Phe Val Lys Asn Ile Leu 
                405                 410                 415     


Pro Lys Gly Ala Ala Ile Lys Asp Gly Arg Leu Gln Ser Gly Asp Arg 
            420                 425                 430         


Ile Leu Glu Val Asn Gly Arg Asp Val Thr Gly Arg Thr Gln Glu Glu 
        435                 440                 445             


Leu Val Ala Met Leu Arg Ser Thr Lys Gln Gly Glu Thr Ala Ser Leu 
    450                 455                 460                 


Val Ile Ala Arg Gln Glu Gly His Phe Leu Pro Arg Glu Leu Asp Gly 
465                 470                 475                 480 


Arg Leu Arg Met Asn Asp Gln Leu Ile Ala Val Asn Gly Glu Ser Leu 
                485                 490                 495     


Leu Gly Lys Ser Asn His Glu Ala Met Glu Thr Leu Arg Arg Ser Met 
            500                 505                 510         


Ser Met Glu Gly Asn Ile Arg Gly Met Ile Gln Leu Val Ile Leu Arg 
        515                 520                 525             


Arg Pro Glu Arg Pro Met Glu Asp Pro Ala Glu Cys Gly Ala Phe Ser 
    530                 535                 540                 


Lys Pro Cys Phe Glu Asn Cys Gln Asn Ala Val Thr Thr Ser Arg Arg 
545                 550                 555                 560 


Asn Asp Asn Ser Ile Leu His Pro Leu Gly Thr Cys Ser Pro Gln Asp 
                565                 570                 575     


Lys Gln Lys Gly Leu Leu Leu Pro Asn Asp Gly Trp Ala Glu Ser Glu 
            580                 585                 590         


Val Pro Pro Ser Pro Thr Pro His Ser Ala Leu Gly Leu Gly Leu Glu 
        595                 600                 605             


Asp Tyr Ser His Ser Ser Gly Val Asp Ser Ala Val Tyr Phe Pro Asp 
    610                 615                 620                 


Gln His Ile Asn Phe Arg Ser Val Thr Pro Ala Arg Gln Pro Glu Ser 
625                 630                 635                 640 


Ile Asn Leu Lys Ala Ser Lys Ser Met Asp Leu Val Pro Asp Glu Ser 
                645                 650                 655     


Lys Val His Ser Leu Ala Gly Gln Lys Ser Glu Ser Pro Ser Lys Asp 
            660                 665                 670         


Phe Gly Pro Thr Leu Gly Leu Lys Lys Ser Ser Ser Leu Glu Ser Leu 
        675                 680                 685             


Gln Thr Ala Val Ala Glu Val Arg Lys Asn Asp Leu Pro Phe His Arg 
    690                 695                 700                 


Pro Arg Pro His Met Val Arg Gly Arg Gly Cys Asn Glu Ser Phe Arg 
705                 710                 715                 720 


Ala Ala Ile Asp Lys Ser Tyr Asp Gly Pro Glu Glu Ile Glu Ala Asp 
                725                 730                 735     


Gly Leu Ser Asp Lys Ser Ser His Ser Gly Gln Gly Ala Leu Asn Cys 
            740                 745                 750         


Glu Ser Ala Pro Gln Gly Asn Ser Glu Leu Glu Asp Met Glu Asn Lys 
        755                 760                 765             


Ala Arg Lys Val Lys Lys Thr Lys Glu Lys Glu Lys Lys Lys Glu Lys 
    770                 775                 780                 


Gly Lys Leu Lys Val Lys Glu Lys Lys Arg Lys Glu Glu Asn Glu Asp 
785                 790                 795                 800 


Pro Glu Arg Lys Ile Lys Lys Lys Gly Phe Gly Ala Met Leu Arg Phe 
                805                 810                 815     


Gly Lys Lys Lys Glu Asp Lys Gly Gly Lys Ala Glu Gln Lys Gly Thr 
            820                 825                 830         


Leu Lys His Gly Gly Leu Arg Glu Glu Glu Leu Glu Lys Met Lys Glu 
        835                 840                 845             


Glu Arg Glu Arg Ile Gly Ala Lys His Gln Glu Leu Arg Glu Lys Gln 
    850                 855                 860                 


Ala Arg Gly Leu Leu Asp Tyr Ala Thr Gly Ala Ile Gly Ser Val Tyr 
865                 870                 875                 880 


Asp Met Asp Asp Asp Glu Met Asp Pro Asn Tyr Ala Arg Val Asn His 
                885                 890                 895     


Phe Arg Glu Pro Cys Thr Ser Ala Asn Val Phe Arg Ser Pro Ser Pro 
            900                 905                 910         


Pro Arg Ala Gly Pro Phe Gly Tyr Pro Arg Asp Gly His Pro Leu Ser 
        915                 920                 925             


Pro Glu Arg Asp His Leu Glu Gly Leu Tyr Ala Lys Val Asn Lys Pro 
    930                 935                 940                 


Tyr His Pro Leu Val Pro Ala Asp Ser Gly Arg Pro Thr Gly Gly Ser 
945                 950                 955                 960 


Thr Asp Arg Ile Gln Lys Leu Arg Lys Glu Tyr Tyr Gln Ala Arg Arg 
                965                 970                 975     


Glu Gly Phe Pro Leu Tyr Glu Asp Asp Glu Gly Arg Ala Arg Pro Ser 
            980                 985                 990         


Glu Tyr Asp Leu Leu Trp Val Pro  Gly Arg Gly Pro Asp  Gly Asn Ala 
        995                 1000                 1005             


His Asn  Leu Arg Phe Glu Gly  Met Glu Arg Gln Tyr  Ala Ser Leu 
    1010                 1015                 1020             


Pro Arg  Gly Gly Pro Ala Asp  Pro Val Asp Tyr Leu  Pro Ala Ala 
    1025                 1030                 1035             


Pro Arg  Gly Leu Tyr Lys Glu  Arg Glu Leu Pro Tyr  Tyr Pro Gly 
    1040                 1045                 1050             


Ala His  Pro Met His Pro Pro  Lys Gly Ser Tyr Pro  Arg Pro Thr 
    1055                 1060                 1065             


Glu Leu  Arg Val Ala Asp Leu  Arg Tyr Pro Gln His  Tyr Pro Pro 
    1070                 1075                 1080             


Pro Pro  Ala Pro Gln His Lys  Gly Pro Phe Arg Gln  Asp Val Pro 
    1085                 1090                 1095             


Pro Ser  Pro Pro Gln His Gln  Arg Met Pro Ala Tyr  Gln Glu Thr 
    1100                 1105                 1110             


Gly Arg  Pro Gly Pro Arg Gly  Gly Ser Pro Asp Gln  Tyr Pro Tyr 
    1115                 1120                 1125             


Arg Thr  Gln Asp Ser Arg Gln  Lys Asn Pro Met Thr  Ala Ala Val 
    1130                 1135                 1140             

<210>  1512
<211>  3312
<212>  DNA
<213>  Homo sapiens

<400>  1512
atgaaagtga ccgtgtgctt cggcaggacg ggcatcgtgg tgccctgcaa ggagggccag     60

ctgcgcgtcg gcgagctcac ccagcaggcg ctgcagcggt acctgaagac ccgggagaag    120

gagctgattg ctgtgtttga agaacaagaa ccactccaca agattgagag ccccagtgga    180

aaccctgcag atcggcagag cccagatgct tttgagacag aagtggccgc ccaactggcc    240

gcatttaagc caattggtgg ggagattgaa gtaacccctt ctgctctaaa actaggcact    300

ccactgctgg tgaggagaag cagtgaccca gtgccaggcc cacctgctga tacccagcca    360

agcgcttcac accctggtgg ccagagtctg aaactggttg ttccagattc cacgcagaac    420

ttggaagaca gagaagtttt gaatggtgta cagacagaac tactaacttc gccaagaact    480

aaggacacat tgagtgatat gacaagaaca gtggagattt ctggggaagg aggcccattg    540

ggaatacatg tagtgccctt cttttcatct ctgagtggaa ggattctagg actcttcatc    600

cgaggcattg aagacaacag caggtccaag cgggagggac tatttcacga aaatgaatgt    660

attgtaaaaa tcaacaatgt ggatctcgta gacaaaacct ttgctcaggc tcaagatgtc    720

ttccgccagg caatgaaatc tccaagtgtg ctcctccacg tgcttcctcc acaaaaccgt    780

gaacagtatg aaaagtcagt cattggctct cttaacattt ttggtaataa tgatggcgtt    840

ttgaaaacca aagtgccgcc tcctgtccat ggaaaatcgg gactaaagac agcaaatctc    900

acaggaaccg atagtcctga aacagatgca tcagcttccc tgcaacaaaa caagagtccc    960

cgagtaccaa ggctgggagg aaaaccatcc tctccctcac tctcgcctct catgggattt   1020

ggcagcaata aaaatgcaaa gaaaattaag attgacctaa agaaaggccc tgaaggactt   1080

ggtttcactg tggttaccag agactcttcc atacatggtc ccggtcccat ttttgtaaaa   1140

aacattttac caaagggagc agcaataaaa gatggccgcc tacaatcagg ggacagaatt   1200

ttggaggtaa atgggagaga tgtcaccgga cgaacccagg aagagcttgt ggccatgctc   1260

aggagcacca agcaggggga gacagcatcg ctggtcattg cccgccaaga aggacatttt   1320

ctgccccgag agttgaaagg agaacctgac tgctgtgcac tctctctgga gacaagcgag   1380

cagctcacct ttgagatccc cctgaatgat tcaggttctg ctggcctcgg ggtgagctta   1440

aaagggaaca aatccagaga aactggaaca gacttgggga tttttatcaa atccatcatt   1500

catggaggcg ctgcttttaa ggatggtcgt ctgcgaatga atgaccagct gattgcagtt   1560

aatggggaat ctcttttggg aaagtccaac cacgaagcta tggaaacact taggcggtca   1620

atgtccatgg agggaaacat ccgagggatg atccagttgg tgattctgag gaggccagag   1680

agaccaatgg aggatcctgc agagtgtggg gcattttcca agccatgctt tgagaactgt   1740

caaaatgctg taaccacctc taggcgaaat gataatagta tcctgcatcc acttggcact   1800

tgcagtccac aagacaaaca gaaaggtcta ttgctgccca atgacggatg ggccgagagt   1860

gaagttccac cttctccaac accacattct gctctgggat tgggcctcga agattacagc   1920

cacagctctg gggtggattc agcagtatat tttccagatc agcacatcaa cttcagatct   1980

gtgacaccgg ccaggcagcc tgaatcaatt aatttgaaag cctcgaagag catggacctt   2040

gtgccagatg aaagcaaggt tcactcattg gctggacaaa aatcggacgg tctgtctgat   2100

aagagctctc actctggcca aggagctctg aattgtgagt ctgcccctca ggggaattcg   2160

gagctagagg acatggaaaa taaagccagg aaagtcaaaa aaacgaaaga gaaggagaag   2220

aaaaaggaaa agggcaaatt gaaagtcaag gagaaaaagc gcaaagagga gaatgaagat   2280

ccagaaagga aaataaagaa gaagggcttc ggcgccatgc tgagatttgg aaagaagaaa   2340

gaggataagg gtggaaaggc tgagcagaaa ggtactctga aacatggtgg cctgagagaa   2400

gaagagctgg agaaaatgaa agaagagcgt gaaaggattg gagcaaaaca tcaggagcta   2460

agggaaaagc aggcaagagg tcttcttgat tatgctactg gtgcaattgg atcagtgtat   2520

gatatggatg atgatgaaat ggaccccaat tatgccagag tgaaccactt tcgggaacca   2580

tgcacatcag caaatgtctt tagatctcca tctccccctc gagctggacc atttggttac   2640

cctcgggatg gccatccact gtctccagaa agagaccact tagagggtct ctatgccaag   2700

gtcaacaagc cataccatcc actggttcca gctgacagtg gccgtcctac gggtggaagc   2760

actgaccgta tccagaagtt gcggaaagag tattatcagg ctcggaggga aggtttccct   2820

ttatatgaag acgacgaagg aagagcaagg ccatctgagt atgacctact ctgggtgcct   2880

ggaaggggtc cagatgggaa tgcacacaac ctccgctttg aagggatgga gaggcagtac   2940

gcatccttac ccaggggagg acccgcagat cctgtagact atctgccagc agcacctcgg   3000

gggctctaca aggaaaggga gcttccctat tatccagggg ctcatcctat gcaccctccc   3060

aaagggagct atccccgccc cacagagctc agggtggcag atctccggta tcctcagcac   3120

tacccacccc cgccagctcc ccagcacaaa ggaccctttc gacaagacgt tccgccttcc   3180

cctccccagc accaaagaat gccagcctat caggaaacag gcagaccagg gccccgtggg   3240

ggcagcccag accagtaccc ttaccgaacc caggattccc ggcagaagaa ccccatgact   3300

gcagccgtat ag                                                       3312


<210>  1513
<211>  1103
<212>  PRT
<213>  Homo sapiens

<400>  1513


Met Lys Val Thr Val Cys Phe Gly Arg Thr Gly Ile Val Val Pro Cys 
1               5                   10                  15      


Lys Glu Gly Gln Leu Arg Val Gly Glu Leu Thr Gln Gln Ala Leu Gln 
            20                  25                  30          


Arg Tyr Leu Lys Thr Arg Glu Lys Glu Leu Ile Ala Val Phe Glu Glu 
        35                  40                  45              


Gln Glu Pro Leu His Lys Ile Glu Ser Pro Ser Gly Asn Pro Ala Asp 
    50                  55                  60                  


Arg Gln Ser Pro Asp Ala Phe Glu Thr Glu Val Ala Ala Gln Leu Ala 
65                  70                  75                  80  


Ala Phe Lys Pro Ile Gly Gly Glu Ile Glu Val Thr Pro Ser Ala Leu 
                85                  90                  95      


Lys Leu Gly Thr Pro Leu Leu Val Arg Arg Ser Ser Asp Pro Val Pro 
            100                 105                 110         


Gly Pro Pro Ala Asp Thr Gln Pro Ser Ala Ser His Pro Gly Gly Gln 
        115                 120                 125             


Ser Leu Lys Leu Val Val Pro Asp Ser Thr Gln Asn Leu Glu Asp Arg 
    130                 135                 140                 


Glu Val Leu Asn Gly Val Gln Thr Glu Leu Leu Thr Ser Pro Arg Thr 
145                 150                 155                 160 


Lys Asp Thr Leu Ser Asp Met Thr Arg Thr Val Glu Ile Ser Gly Glu 
                165                 170                 175     


Gly Gly Pro Leu Gly Ile His Val Val Pro Phe Phe Ser Ser Leu Ser 
            180                 185                 190         


Gly Arg Ile Leu Gly Leu Phe Ile Arg Gly Ile Glu Asp Asn Ser Arg 
        195                 200                 205             


Ser Lys Arg Glu Gly Leu Phe His Glu Asn Glu Cys Ile Val Lys Ile 
    210                 215                 220                 


Asn Asn Val Asp Leu Val Asp Lys Thr Phe Ala Gln Ala Gln Asp Val 
225                 230                 235                 240 


Phe Arg Gln Ala Met Lys Ser Pro Ser Val Leu Leu His Val Leu Pro 
                245                 250                 255     


Pro Gln Asn Arg Glu Gln Tyr Glu Lys Ser Val Ile Gly Ser Leu Asn 
            260                 265                 270         


Ile Phe Gly Asn Asn Asp Gly Val Leu Lys Thr Lys Val Pro Pro Pro 
        275                 280                 285             


Val His Gly Lys Ser Gly Leu Lys Thr Ala Asn Leu Thr Gly Thr Asp 
    290                 295                 300                 


Ser Pro Glu Thr Asp Ala Ser Ala Ser Leu Gln Gln Asn Lys Ser Pro 
305                 310                 315                 320 


Arg Val Pro Arg Leu Gly Gly Lys Pro Ser Ser Pro Ser Leu Ser Pro 
                325                 330                 335     


Leu Met Gly Phe Gly Ser Asn Lys Asn Ala Lys Lys Ile Lys Ile Asp 
            340                 345                 350         


Leu Lys Lys Gly Pro Glu Gly Leu Gly Phe Thr Val Val Thr Arg Asp 
        355                 360                 365             


Ser Ser Ile His Gly Pro Gly Pro Ile Phe Val Lys Asn Ile Leu Pro 
    370                 375                 380                 


Lys Gly Ala Ala Ile Lys Asp Gly Arg Leu Gln Ser Gly Asp Arg Ile 
385                 390                 395                 400 


Leu Glu Val Asn Gly Arg Asp Val Thr Gly Arg Thr Gln Glu Glu Leu 
                405                 410                 415     


Val Ala Met Leu Arg Ser Thr Lys Gln Gly Glu Thr Ala Ser Leu Val 
            420                 425                 430         


Ile Ala Arg Gln Glu Gly His Phe Leu Pro Arg Glu Leu Lys Gly Glu 
        435                 440                 445             


Pro Asp Cys Cys Ala Leu Ser Leu Glu Thr Ser Glu Gln Leu Thr Phe 
    450                 455                 460                 


Glu Ile Pro Leu Asn Asp Ser Gly Ser Ala Gly Leu Gly Val Ser Leu 
465                 470                 475                 480 


Lys Gly Asn Lys Ser Arg Glu Thr Gly Thr Asp Leu Gly Ile Phe Ile 
                485                 490                 495     


Lys Ser Ile Ile His Gly Gly Ala Ala Phe Lys Asp Gly Arg Leu Arg 
            500                 505                 510         


Met Asn Asp Gln Leu Ile Ala Val Asn Gly Glu Ser Leu Leu Gly Lys 
        515                 520                 525             


Ser Asn His Glu Ala Met Glu Thr Leu Arg Arg Ser Met Ser Met Glu 
    530                 535                 540                 


Gly Asn Ile Arg Gly Met Ile Gln Leu Val Ile Leu Arg Arg Pro Glu 
545                 550                 555                 560 


Arg Pro Met Glu Asp Pro Ala Glu Cys Gly Ala Phe Ser Lys Pro Cys 
                565                 570                 575     


Phe Glu Asn Cys Gln Asn Ala Val Thr Thr Ser Arg Arg Asn Asp Asn 
            580                 585                 590         


Ser Ile Leu His Pro Leu Gly Thr Cys Ser Pro Gln Asp Lys Gln Lys 
        595                 600                 605             


Gly Leu Leu Leu Pro Asn Asp Gly Trp Ala Glu Ser Glu Val Pro Pro 
    610                 615                 620                 


Ser Pro Thr Pro His Ser Ala Leu Gly Leu Gly Leu Glu Asp Tyr Ser 
625                 630                 635                 640 


His Ser Ser Gly Val Asp Ser Ala Val Tyr Phe Pro Asp Gln His Ile 
                645                 650                 655     


Asn Phe Arg Ser Val Thr Pro Ala Arg Gln Pro Glu Ser Ile Asn Leu 
            660                 665                 670         


Lys Ala Ser Lys Ser Met Asp Leu Val Pro Asp Glu Ser Lys Val His 
        675                 680                 685             


Ser Leu Ala Gly Gln Lys Ser Asp Gly Leu Ser Asp Lys Ser Ser His 
    690                 695                 700                 


Ser Gly Gln Gly Ala Leu Asn Cys Glu Ser Ala Pro Gln Gly Asn Ser 
705                 710                 715                 720 


Glu Leu Glu Asp Met Glu Asn Lys Ala Arg Lys Val Lys Lys Thr Lys 
                725                 730                 735     


Glu Lys Glu Lys Lys Lys Glu Lys Gly Lys Leu Lys Val Lys Glu Lys 
            740                 745                 750         


Lys Arg Lys Glu Glu Asn Glu Asp Pro Glu Arg Lys Ile Lys Lys Lys 
        755                 760                 765             


Gly Phe Gly Ala Met Leu Arg Phe Gly Lys Lys Lys Glu Asp Lys Gly 
    770                 775                 780                 


Gly Lys Ala Glu Gln Lys Gly Thr Leu Lys His Gly Gly Leu Arg Glu 
785                 790                 795                 800 


Glu Glu Leu Glu Lys Met Lys Glu Glu Arg Glu Arg Ile Gly Ala Lys 
                805                 810                 815     


His Gln Glu Leu Arg Glu Lys Gln Ala Arg Gly Leu Leu Asp Tyr Ala 
            820                 825                 830         


Thr Gly Ala Ile Gly Ser Val Tyr Asp Met Asp Asp Asp Glu Met Asp 
        835                 840                 845             


Pro Asn Tyr Ala Arg Val Asn His Phe Arg Glu Pro Cys Thr Ser Ala 
    850                 855                 860                 


Asn Val Phe Arg Ser Pro Ser Pro Pro Arg Ala Gly Pro Phe Gly Tyr 
865                 870                 875                 880 


Pro Arg Asp Gly His Pro Leu Ser Pro Glu Arg Asp His Leu Glu Gly 
                885                 890                 895     


Leu Tyr Ala Lys Val Asn Lys Pro Tyr His Pro Leu Val Pro Ala Asp 
            900                 905                 910         


Ser Gly Arg Pro Thr Gly Gly Ser Thr Asp Arg Ile Gln Lys Leu Arg 
        915                 920                 925             


Lys Glu Tyr Tyr Gln Ala Arg Arg Glu Gly Phe Pro Leu Tyr Glu Asp 
    930                 935                 940                 


Asp Glu Gly Arg Ala Arg Pro Ser Glu Tyr Asp Leu Leu Trp Val Pro 
945                 950                 955                 960 


Gly Arg Gly Pro Asp Gly Asn Ala His Asn Leu Arg Phe Glu Gly Met 
                965                 970                 975     


Glu Arg Gln Tyr Ala Ser Leu Pro Arg Gly Gly Pro Ala Asp Pro Val 
            980                 985                 990         


Asp Tyr Leu Pro Ala Ala Pro Arg  Gly Leu Tyr Lys Glu  Arg Glu Leu 
        995                 1000                 1005             


Pro Tyr  Tyr Pro Gly Ala His  Pro Met His Pro Pro  Lys Gly Ser 
    1010                 1015                 1020             


Tyr Pro  Arg Pro Thr Glu Leu  Arg Val Ala Asp Leu  Arg Tyr Pro 
    1025                 1030                 1035             


Gln His  Tyr Pro Pro Pro Pro  Ala Pro Gln His Lys  Gly Pro Phe 
    1040                 1045                 1050             


Arg Gln  Asp Val Pro Pro Ser  Pro Pro Gln His Gln  Arg Met Pro 
    1055                 1060                 1065             


Ala Tyr  Gln Glu Thr Gly Arg  Pro Gly Pro Arg Gly  Gly Ser Pro 
    1070                 1075                 1080             


Asp Gln  Tyr Pro Tyr Arg Thr  Gln Asp Ser Arg Gln  Lys Asn Pro 
    1085                 1090                 1095             


Met Thr  Ala Ala Val 
    1100             

<210>  1514
<211>  2362
<212>  DNA
<213>  Homo sapiens

<400>  1514
gccggaatct cgcgagagct cccgggggcc gttgggtagc gtcttcgctg ttgcccttag     60

ggacggctgt gggcctgctg ggggtggggg cccgaagcgc cagagatggc tgctcagcga    120

gggatgccca gctccgccgt gagggtcctg gaagaggcgt tgggcatggg tttgacggca    180

gccggggacg cgagggacac ggcggacgcg gtggcggctg agggcgccta ctacctggaa    240

ccttatctat atccagtgcc cttgctactg aatgattaaa acttgacaag atattcagag    300

gtcaccataa ctgaagcatc tgaagatgac tatgaatatg aagagataaa agcagttgcc    360

cacaaactaa tcctgaattt attagaagtg acgtttattg acatttacaa ggaagtcaga    420

agaaagcagt tattcatttt tcatggatct tcagaatgac atgataccag atgacaattt    480

tagcatccca gaaggtgaag aagatctggc aaaagcaatt cagatggccc aagaacaggc    540

tacagatact gaaattttgg aacggaaaac agttcttcct tcaaagcatg cagtacctga    600

agtaatagaa gactttctct gcaatttctt gatcaaaatg ggaatgacca gaactcttga    660

ttgctttcag tctgaatggt atgagttaat acagaaagga gtgactgaac ttagaactgt    720

tgggaatgtt ccagatgtct acacccagat tatgcttttg gaaaatgaga acaaaaattt    780

aaagaaagat ttgaagcact acaaacaagc agctgacaaa gctagagaag atttgctgaa    840

aattcagaaa gaacgtgatt ttcatcgaat gcatcataag cgaatagtcc aggaaaaaaa    900

caaattaatt aatgacctca aagggttgaa gttacattat gcatcttatg aaccgactat    960

aagggtgtta catgagaaac accacacttt actgaaggag aaaatgctga cctccttgga   1020

aagagacaaa gtagttgggc agatttctgg acttcaagaa acattgaaga aactgcaaag   1080

aggacatagt taccatggtc ctcaaattaa agttgatcat agtcgtgaaa aagaaaatgc   1140

accagaaggt cctactcaga aaggtcttcg tgaagccagg gaacaaaaca aatgtaaaac   1200

aaagatgaaa ggcaatacaa aggattcaga atttcccata gatatgcaac caaatccaaa   1260

cctgaatgtt tctaaagaaa gtctttctcc agcaaaattt gactacaagc tgaaaaacat   1320

ttttagactc catgaacttc cagtgagctg tgtctccatg caaccccaca aagacatcct   1380

agtctcctgt ggcgaggacc gactctggaa ggtgttgggc cttccaaaat gcaatgtgct   1440

tctcacggga tttggccaca ctgactggct ttcagactgc tgcttccatc ccagtggcga   1500

caaattggct acttcaagtg gtgacactac agttaaatta tgggatctat gtaaaggcga   1560

ttgcattttg acctttgaag gacacagccg cgcagtgtgg tcctgcacat ggcactcctg   1620

cggcaatttt gtggcttcct cctcactgga taaaactagc aaaatttggg atgttaatag   1680

tgaaagatgc agatgtactt tgtatggaca tacagattct gtgaacagca ttgagttttt   1740

tcctttctcc aatactcttc tcacaagctc tgcagacaag accctgtcta tatgggatgc   1800

aagaacaggt atatgtgagc agtcacttta tggtcacatg cattctatca atgatgccat   1860

ttttgatccc aggggtcaca tgatagcatc ctgtgatgcc tgtggggtta caaagctgtg   1920

ggactttcgg aagctgttac caattgtgtc catcgatata ggtccaagtc ctggcaatga   1980

ggtgaatttt gattcatcag gtcgagtttt agctcaggca agtggcaatg gtgttatcca   2040

tttgctagat cttaaatctg gggagattca caaattgatg ggccacgaaa acgaggcaca   2100

cacggttgtg ttttctcacg acggggagat tctcttttct ggaggctctg acggcacagt   2160

tcgaacgtgg tcttgaccgt cagcacatcc cgctgcagag ggcattccct ttaaggcttg   2220

aaaatgcctc ctgtagtccc aaaccagcaa agaactggtt aaatgtgcca gcaggtaaca   2280

tttacagtct gctttaaaac atgctttgga catatatttt agtgctcata ctgttactaa   2340

taaaaaaata actttatgct ca                                            2362


<210>  1515
<211>  577
<212>  PRT
<213>  Homo sapiens

<400>  1515


Met Asp Leu Gln Asn Asp Met Ile Pro Asp Asp Asn Phe Ser Ile Pro 
1               5                   10                  15      


Glu Gly Glu Glu Asp Leu Ala Lys Ala Ile Gln Met Ala Gln Glu Gln 
            20                  25                  30          


Ala Thr Asp Thr Glu Ile Leu Glu Arg Lys Thr Val Leu Pro Ser Lys 
        35                  40                  45              


His Ala Val Pro Glu Val Ile Glu Asp Phe Leu Cys Asn Phe Leu Ile 
    50                  55                  60                  


Lys Met Gly Met Thr Arg Thr Leu Asp Cys Phe Gln Ser Glu Trp Tyr 
65                  70                  75                  80  


Glu Leu Ile Gln Lys Gly Val Thr Glu Leu Arg Thr Val Gly Asn Val 
                85                  90                  95      


Pro Asp Val Tyr Thr Gln Ile Met Leu Leu Glu Asn Glu Asn Lys Asn 
            100                 105                 110         


Leu Lys Lys Asp Leu Lys His Tyr Lys Gln Ala Ala Asp Lys Ala Arg 
        115                 120                 125             


Glu Asp Leu Leu Lys Ile Gln Lys Glu Arg Asp Phe His Arg Met His 
    130                 135                 140                 


His Lys Arg Ile Val Gln Glu Lys Asn Lys Leu Ile Asn Asp Leu Lys 
145                 150                 155                 160 


Gly Leu Lys Leu His Tyr Ala Ser Tyr Glu Pro Thr Ile Arg Val Leu 
                165                 170                 175     


His Glu Lys His His Thr Leu Leu Lys Glu Lys Met Leu Thr Ser Leu 
            180                 185                 190         


Glu Arg Asp Lys Val Val Gly Gln Ile Ser Gly Leu Gln Glu Thr Leu 
        195                 200                 205             


Lys Lys Leu Gln Arg Gly His Ser Tyr His Gly Pro Gln Ile Lys Val 
    210                 215                 220                 


Asp His Ser Arg Glu Lys Glu Asn Ala Pro Glu Gly Pro Thr Gln Lys 
225                 230                 235                 240 


Gly Leu Arg Glu Ala Arg Glu Gln Asn Lys Cys Lys Thr Lys Met Lys 
                245                 250                 255     


Gly Asn Thr Lys Asp Ser Glu Phe Pro Ile Asp Met Gln Pro Asn Pro 
            260                 265                 270         


Asn Leu Asn Val Ser Lys Glu Ser Leu Ser Pro Ala Lys Phe Asp Tyr 
        275                 280                 285             


Lys Leu Lys Asn Ile Phe Arg Leu His Glu Leu Pro Val Ser Cys Val 
    290                 295                 300                 


Ser Met Gln Pro His Lys Asp Ile Leu Val Ser Cys Gly Glu Asp Arg 
305                 310                 315                 320 


Leu Trp Lys Val Leu Gly Leu Pro Lys Cys Asn Val Leu Leu Thr Gly 
                325                 330                 335     


Phe Gly His Thr Asp Trp Leu Ser Asp Cys Cys Phe His Pro Ser Gly 
            340                 345                 350         


Asp Lys Leu Ala Thr Ser Ser Gly Asp Thr Thr Val Lys Leu Trp Asp 
        355                 360                 365             


Leu Cys Lys Gly Asp Cys Ile Leu Thr Phe Glu Gly His Ser Arg Ala 
    370                 375                 380                 


Val Trp Ser Cys Thr Trp His Ser Cys Gly Asn Phe Val Ala Ser Ser 
385                 390                 395                 400 


Ser Leu Asp Lys Thr Ser Lys Ile Trp Asp Val Asn Ser Glu Arg Cys 
                405                 410                 415     


Arg Cys Thr Leu Tyr Gly His Thr Asp Ser Val Asn Ser Ile Glu Phe 
            420                 425                 430         


Phe Pro Phe Ser Asn Thr Leu Leu Thr Ser Ser Ala Asp Lys Thr Leu 
        435                 440                 445             


Ser Ile Trp Asp Ala Arg Thr Gly Ile Cys Glu Gln Ser Leu Tyr Gly 
    450                 455                 460                 


His Met His Ser Ile Asn Asp Ala Ile Phe Asp Pro Arg Gly His Met 
465                 470                 475                 480 


Ile Ala Ser Cys Asp Ala Cys Gly Val Thr Lys Leu Trp Asp Phe Arg 
                485                 490                 495     


Lys Leu Leu Pro Ile Val Ser Ile Asp Ile Gly Pro Ser Pro Gly Asn 
            500                 505                 510         


Glu Val Asn Phe Asp Ser Ser Gly Arg Val Leu Ala Gln Ala Ser Gly 
        515                 520                 525             


Asn Gly Val Ile His Leu Leu Asp Leu Lys Ser Gly Glu Ile His Lys 
    530                 535                 540                 


Leu Met Gly His Glu Asn Glu Ala His Thr Val Val Phe Ser His Asp 
545                 550                 555                 560 


Gly Glu Ile Leu Phe Ser Gly Gly Ser Asp Gly Thr Val Arg Thr Trp 
                565                 570                 575     


Ser 
    

<210>  1516
<211>  2174
<212>  DNA
<213>  Homo sapiens

<400>  1516
gagagctccc gggggccgtt gggtagcgtc ttcgctgttg cccttaggga cggctgtggg     60

cctgctgggg gtgggggccc gaagcgccag agatggctgc tcagcgaggg atgcccagct    120

ccgccgtgag ggtcctggaa gaggcgttgg gcatgggttt gacggcagcc ggggacgcga    180

gggacacggc ggacgcggtg gcggctgagg gcgcctacta cctggaacag gtcaccataa    240

ctgaagcatc tgaagatgac tatgaatatg aagagatacc agatgacaat tttagcatcc    300

cagaaggtga agaagatctg gcaaaagcaa ttcagatggc ccaagaacag gctacagata    360

ctgaaatttt ggaacggaaa acagttcttc cttcaaagca tgcagtacct gaagtaatag    420

aagactttct ctgcaatttc ttgatcaaaa tgggaatgac cagaactctt gattgctttc    480

agtctgaatg gtatgagtta atacagaaag gagtgactga acttagaact gttgggaatg    540

ttccagatgt ctacacccag attatgcttt tggaaaatga gaacaaaaat ttaaagaaag    600

atttgaagca ctacaaacaa gcagctgaca aagctagaga agatttgctg aaaattcaga    660

aagaacgtga ttttcatcga atgcatcata agcgaatagt ccaggaaaaa aacaaattaa    720

ttaatgacct caaagggttg aagttacatt atgcatctta tgaaccgact ataagggtgt    780

tacatgagaa acaccacact ttactgaagg agaaaatgct gacctccttg gaaagagaca    840

aagtagttgg gcagatttct ggacttcaag aaacattgaa gaaactgcaa agaggacata    900

gttaccatgg tcctcaaatt aaagttgatc atagtcgtga aaaagaaaat gcaccagaag    960

gtcctactca gaaaggtctt cgtgaagcca gggaacaaaa caaatgtaaa acaaagatga   1020

aaggcaatac aaaggattca gaatttccca tagatatgca accaaatcca aacctgaatg   1080

tttctaaaga aagtctttct ccagcaaaat ttgactacaa gctgaaaaac atttttagac   1140

tccatgaact tccagtgagc tgtgtctcca tgcaacccca caaagacatc ctagtctcct   1200

gtggcgagga ccgactctgg aaggtgttgg gccttccaaa atgcaatgtg cttctcacgg   1260

gatttggcca cactgactgg ctttcagact gctgcttcca tcccagtggc gacaaattgg   1320

ctacttcaag tggtgacact acagttaaat tatgggatct atgtaaaggc gattgcattt   1380

tgacctttga aggacacagc cgcgcagtgt ggtcctgcac atggcactcc tgcggcaatt   1440

ttgtggcttc ctcctcactg gataaaacta gcaaaatttg ggatgttaat agtgaaagat   1500

gcagatgtac tttgtatgga catacagatt ctgtgaacag cattgagttt tttcctttct   1560

ccaatactct tctcacaagc tctgcagaca agaccctgtc tatatgggat gcaagaacag   1620

gtatatgtga gcagtcactt tatggtcaca tgcattctat caatgatgcc atttttgatc   1680

ccaggggtca catgatagca tcctgtgatg cctgtggggt tacaaagctg tgggactttc   1740

ggaagctgtt accaattgtg tccatcgata taggtccaag tcctggcaat gaggtgaatt   1800

ttgattcatc aggtcgagtt ttagctcagg caagtggcaa tggtgttatc catttgctag   1860

atcttaaatc tggggagatt cacaaattga tgggccacga aaacgaggca cacacggttg   1920

tgttttctca cgacggggag attctctttt ctggaggctc tgacggcaca gttcgaacgt   1980

ggtcttgacc gtcagcacat cccgctgcag agggcattcc ctttaaggct tgaaaatgcc   2040

tcctgtagtc ccaaaccagc aaagaactgg ttaaatgtgc cagcaggtaa catttacagt   2100

ctgctttaaa acatgctttg gacatatatt ttagtgctca tactgttact aataaaaaaa   2160

taactttatg ctca                                                     2174


<210>  1517
<211>  631
<212>  PRT
<213>  Homo sapiens

<400>  1517


Met Ala Ala Gln Arg Gly Met Pro Ser Ser Ala Val Arg Val Leu Glu 
1               5                   10                  15      


Glu Ala Leu Gly Met Gly Leu Thr Ala Ala Gly Asp Ala Arg Asp Thr 
            20                  25                  30          


Ala Asp Ala Val Ala Ala Glu Gly Ala Tyr Tyr Leu Glu Gln Val Thr 
        35                  40                  45              


Ile Thr Glu Ala Ser Glu Asp Asp Tyr Glu Tyr Glu Glu Ile Pro Asp 
    50                  55                  60                  


Asp Asn Phe Ser Ile Pro Glu Gly Glu Glu Asp Leu Ala Lys Ala Ile 
65                  70                  75                  80  


Gln Met Ala Gln Glu Gln Ala Thr Asp Thr Glu Ile Leu Glu Arg Lys 
                85                  90                  95      


Thr Val Leu Pro Ser Lys His Ala Val Pro Glu Val Ile Glu Asp Phe 
            100                 105                 110         


Leu Cys Asn Phe Leu Ile Lys Met Gly Met Thr Arg Thr Leu Asp Cys 
        115                 120                 125             


Phe Gln Ser Glu Trp Tyr Glu Leu Ile Gln Lys Gly Val Thr Glu Leu 
    130                 135                 140                 


Arg Thr Val Gly Asn Val Pro Asp Val Tyr Thr Gln Ile Met Leu Leu 
145                 150                 155                 160 


Glu Asn Glu Asn Lys Asn Leu Lys Lys Asp Leu Lys His Tyr Lys Gln 
                165                 170                 175     


Ala Ala Asp Lys Ala Arg Glu Asp Leu Leu Lys Ile Gln Lys Glu Arg 
            180                 185                 190         


Asp Phe His Arg Met His His Lys Arg Ile Val Gln Glu Lys Asn Lys 
        195                 200                 205             


Leu Ile Asn Asp Leu Lys Gly Leu Lys Leu His Tyr Ala Ser Tyr Glu 
    210                 215                 220                 


Pro Thr Ile Arg Val Leu His Glu Lys His His Thr Leu Leu Lys Glu 
225                 230                 235                 240 


Lys Met Leu Thr Ser Leu Glu Arg Asp Lys Val Val Gly Gln Ile Ser 
                245                 250                 255     


Gly Leu Gln Glu Thr Leu Lys Lys Leu Gln Arg Gly His Ser Tyr His 
            260                 265                 270         


Gly Pro Gln Ile Lys Val Asp His Ser Arg Glu Lys Glu Asn Ala Pro 
        275                 280                 285             


Glu Gly Pro Thr Gln Lys Gly Leu Arg Glu Ala Arg Glu Gln Asn Lys 
    290                 295                 300                 


Cys Lys Thr Lys Met Lys Gly Asn Thr Lys Asp Ser Glu Phe Pro Ile 
305                 310                 315                 320 


Asp Met Gln Pro Asn Pro Asn Leu Asn Val Ser Lys Glu Ser Leu Ser 
                325                 330                 335     


Pro Ala Lys Phe Asp Tyr Lys Leu Lys Asn Ile Phe Arg Leu His Glu 
            340                 345                 350         


Leu Pro Val Ser Cys Val Ser Met Gln Pro His Lys Asp Ile Leu Val 
        355                 360                 365             


Ser Cys Gly Glu Asp Arg Leu Trp Lys Val Leu Gly Leu Pro Lys Cys 
    370                 375                 380                 


Asn Val Leu Leu Thr Gly Phe Gly His Thr Asp Trp Leu Ser Asp Cys 
385                 390                 395                 400 


Cys Phe His Pro Ser Gly Asp Lys Leu Ala Thr Ser Ser Gly Asp Thr 
                405                 410                 415     


Thr Val Lys Leu Trp Asp Leu Cys Lys Gly Asp Cys Ile Leu Thr Phe 
            420                 425                 430         


Glu Gly His Ser Arg Ala Val Trp Ser Cys Thr Trp His Ser Cys Gly 
        435                 440                 445             


Asn Phe Val Ala Ser Ser Ser Leu Asp Lys Thr Ser Lys Ile Trp Asp 
    450                 455                 460                 


Val Asn Ser Glu Arg Cys Arg Cys Thr Leu Tyr Gly His Thr Asp Ser 
465                 470                 475                 480 


Val Asn Ser Ile Glu Phe Phe Pro Phe Ser Asn Thr Leu Leu Thr Ser 
                485                 490                 495     


Ser Ala Asp Lys Thr Leu Ser Ile Trp Asp Ala Arg Thr Gly Ile Cys 
            500                 505                 510         


Glu Gln Ser Leu Tyr Gly His Met His Ser Ile Asn Asp Ala Ile Phe 
        515                 520                 525             


Asp Pro Arg Gly His Met Ile Ala Ser Cys Asp Ala Cys Gly Val Thr 
    530                 535                 540                 


Lys Leu Trp Asp Phe Arg Lys Leu Leu Pro Ile Val Ser Ile Asp Ile 
545                 550                 555                 560 


Gly Pro Ser Pro Gly Asn Glu Val Asn Phe Asp Ser Ser Gly Arg Val 
                565                 570                 575     


Leu Ala Gln Ala Ser Gly Asn Gly Val Ile His Leu Leu Asp Leu Lys 
            580                 585                 590         


Ser Gly Glu Ile His Lys Leu Met Gly His Glu Asn Glu Ala His Thr 
        595                 600                 605             


Val Val Phe Ser His Asp Gly Glu Ile Leu Phe Ser Gly Gly Ser Asp 
    610                 615                 620                 


Gly Thr Val Arg Thr Trp Ser 
625                 630     

<210>  1518
<211>  5290
<212>  DNA
<213>  Homo sapiens

<400>  1518
gggtagcgtc ttcgctgttg cccttaggga cggctgtggg cctgctgggg gtgggggccc     60

gaagcgccag agatggctgc tcagcgaggg atgcccagct ccgccgtgag ggtcctggaa    120

gaggcgttgg gcatgggttt gacggcagcc ggggacgcga gggacacggc ggacgcggtg    180

gcggctgagg gcgcctacta cctggaacag gtcaccataa ctgaagcatc tgaagatgac    240

tatgaatatg aagagatacc agatgacaat tttagcatcc cagaaggtga agaagatctg    300

gcaaaagcaa ttcagatggc ccaagaacag gctacagata ctgaaatttt gcaaagctag    360

agaagatttg ctgaaaattc agaaagaacg tgattttcat cgaatgcatc ataagcgaat    420

agtccaggaa aaaaacaaat taattaatga cctcaaaggg ttgaagttac attatgcatc    480

ttatgaaccg actataaggg tgttacatga gaaacaccac actttactga aggagaaaat    540

gctgacctcc ttggaaagag acaaagtagt tgggcagatt tctggacttc aagaaacatt    600

gaagaaactg caaagaggac atagttacca tggtcctcaa attaaagttg atcatagtcg    660

tgaaaaagaa aatgcaccag aaggtcctac tcagaaaggt cttcgtgaag ccagggaaca    720

aaacaaatgt aaaacaaaga tgaaaggcaa tacaaaggat tcagaatttc ccatagatat    780

gcaaccaaat ccaaacctga atgtttctaa agaaagtctt tctccagcaa aatttgacta    840

caagctgaaa aacattttta gactccatga acttccagtg agctgtgtct ccatgcaacc    900

ccacaaagac atcctagtct cctgtggcga ggaccgactc tggaaggtgt tgggccttcc    960

aaaatgcaat gtgcttctca cgggatttgg ccacactgac tggctttcag actgctgctt   1020

ccatcccagt ggcgacaaat tggctacttc aagtggtgac actacagtta aattatggga   1080

tctatgtaaa ggcgattgca ttttgacctt tgaaggacac agccgcgcag tgtggtcctg   1140

cacatggcac tcctgcggca attttgtggc ttcctcctca ctggataaaa ctagcaaaat   1200

ttgggatgtt aatagtgaaa gatgcagatg tactttgtat ggacatacag attctgtgaa   1260

cagcattgag ttttttcctt tctccaatac tcttctcaca agctctgcag acaagaccct   1320

gtctatatgg gatgcaagaa caggtatatg tgagcagtca ctttatggtc acatgcattc   1380

tatcaatgat gccatttttg atcccagggg tcacatgata gcatcctgtg atgcctgtgg   1440

ggttacaaag ctgtgggact ttcggaagct gttaccaatt gtgtccatcg atataggtcc   1500

aagtcctggc aatgaggtga attttgattc atcagaaaat accacgtatc tttatagact   1560

aggagctcag atatattatt tccagctttc ttgatgttac ctcatattga agttgccaat   1620

ggtaggactg cacaatctga atacatatga tgagatattt tatgcctcgt tttccatctg   1680

cttgagttag caccctttca ccattggcca tttcatacta cccaatttcc atgtaatttg   1740

tctctctaat cttgtcagcc ccttgaaatg aaggtgcact ttattcaggg attattttca   1800

tgctcaagat cattttgtga attattttat atcattataa ataatcctac tgttaccttt   1860

tcaatacaag aatttgattt cccagcatta atgggttcat tcaatagtag tgccaagttc   1920

atacagcaac actgtaattg cattttaatc agaaactagt aatatatgct gaagatactt   1980

tgttaaatta acattattgc tgtgattaac aaagcacact gttaagtgaa tattgcatga   2040

attaaattac atactagatc acttacatag tttaggattt catgtgctat ctagctacct   2100

cttcccacaa aatctacatc cttatctgtt ttactcataa aaatgtaatt cttgaagctc   2160

ataagcatag ctacttaaat gattcctttg cttaatagaa acatctttgt tcactacaac   2220

aagcttatct gcactacatt ttttaggaat aaaggatatg tgatatgtat tatttgaaaa   2280

ctggcattca attgccacac ttggctgttc accataaaac tcctatttga aatctaactt   2340

tgaggacttc tttgaggata ctagagttat agttctgaaa tagttacttg cagaaatgct   2400

atctattaat ttaaattttg gtttaaaaaa ctcataatat ttttttttga gacaaggatt   2460

cactctgttg cccaggctgg agtgcaatag cacagtcaga gcatattgca gccccaaact   2520

tgtggcctca agtaattctc ctcctttagc ctccagaata gctaagacta caggcaagca   2580

ccaccatgcc tggctaaatt tttttttgaa tgttgtagaa atggagtgcc actatgttgc   2640

ccaggctggt cacaaattcc tgtcctcaag caatcctccc aaagtgctag gattactggc   2700

atgagccact gcacccagcc ttaatcattt ttagtgcaca gtttagtggt attaattata   2760

gtcatgttgt tgtaccacag atctctagaa ctttttcatt ttgcaaaact gacactctgt   2820

acccattaaa caataaatcc tcattttcaa aatgagatag cttctctaga tttagtaaag   2880

ctctcttctt tttcattatt ttgcttttct gtgaaagggg acttcaaatt tattttgagg   2940

aaacaaatgt aaacactcat cttaaagtat gtatattaag actattttaa taatcagagc   3000

aaactttcat ttatttagct attttcagtt tgcagcctac catgccaaac attactttat   3060

tgctgttccc tgcagtcctt ttgacaagga tggagcactg tcagagctgc actggagctg   3120

gagacaggga tagaggacac tcaggatgac agcccccacc cagaatcctg gagaggaaag   3180

ttgctattgt tgaaaacata atggatctgg ttgttattaa agtacctgaa gtcagctgca   3240

taaattggga agcatatgca cgcttctgct ttactgtggc aatttaaaac aatataaatt   3300

tcataaaatt ctcattgaaa aaaaatgacc aagaaaagcc ctaaaaatag taggaaatgt   3360

tacccatcat tacatcctcc accatcaagg ccaagtagtc aatacccacg ccagataagc   3420

actgtgtgcc tatgtgaggt ggtcattaaa gaatgatgag gaaaggacca cagaaatcaa   3480

ctggtgtctt cccaaagtcc tggggacgct gaggaacaca catgggtctc ataatgtcca   3540

tgtccttccc ttatacctca atgctctttc caccttgccc tggtggaaag tcttgtccat   3600

atcacctcta atccagcatt ctcaaagcag cacaaaactg tcttcagaag actgaatgtt   3660

tctacattcc ttcatattaa ttccaggaaa agaattccca agtcaaataa ttcaaatgct   3720

aagtgtattt tttaaaattg tttttaggca ctttctctta ggaatgtaaa ctctttgagg   3780

gcagggtcta tgtcctttca tcattgtgtt catcaggctt tatcattgtc tagcatatgg   3840

tggatggata aacaaccatc tccgtaaaga tatctgattt ctattccaac tacacaagct   3900

ccttttctag tatacacagc caccaaaata atgcttaaaa catatgtctc agaatgacaa   3960

tcaagataga agtcttaaag caagaaagat gttttccttg tttgttcttc tataaattct   4020

ctaaagattc ataaaattta gctatacaat ctacttcaga taatggcttc tagatgctat   4080

gtagaaattg gcccattatg caagataaaa atcatctaag attataatgc aaatcagtca   4140

tcataaaaaa tataaagatc tagaatttat agaaattcta ctgagcattt attttatgtg   4200

aaagaaaaat acatccacag tacatacata attaaatgta aatgtatgct gaaaaagttc   4260

ataatcatga aaaatacata tcttgatgga ctacttttat ttggcaacct ttaccttcca   4320

atatctgtca taatattaga gtagattaga aattatatct acagtctcaa ctcattttat   4380

gaaatatgag taacggtagg tatagataat ttattttccc tcagctgtac ataaagatgg   4440

ataattacat ctttctaaaa aaatgaagct gaccaggcgc ggtggctcac gcctgtaatc   4500

ctagcacttt gggaggccga ggtgggtgga ttgcttgagc tcaggagttc aaaaccagca   4560

tgggcaacac agtgaaactc tgtctctact aaaaatacaa aaaaaaatta gccgggtgtg   4620

gcgatgtgcg actgtagttc ccagttattc gaaaagctga ggcaggagaa ttgcttgaac   4680

ctgagaggcg gagcttgcag tgagcggaga tcacgccact gcactccagc ctgggcgaca   4740

gagcaagact ccgttgccaa aaaaaaaaaa aaaaaagagg aagaagccat taggtctctt   4800

ctaaccttta cctttgcaga ctttaatgtt gtcagctagt ccaacatcat tatgcactat   4860

tatttgaagg tgctcatcca ttttcccagc atcttttgtg ttgtcataac ccttacatgc   4920

agtatcagta aatatggctt tattgtttga caacataaat tccttagtga cgttttcaaa   4980

agaataagag tttttaacca tttagttaaa tagaaataaa ttgatgatgg gaaatgtctg   5040

cattctatgt ttaatttttc tatcaatcta aaactgctct aagaaataga attcattaac   5100

taaagtaatg atgtaggaaa agtttaaact aatttactgt ttacttaaac tgcaatagca   5160

aaggcaggag aataacttaa caaccttaca gttaattatt ttacaggata tgttacctgc   5220

ctttcatctt ccctgagtat aagacaagga agcagactta aactctcatg agagaaatgt   5280

aagttgtata                                                          5290


<210>  1519
<211>  452
<212>  PRT
<213>  Homo sapiens

<400>  1519


Met Thr Met Asn Met Lys Arg Tyr Gln Met Thr Ile Leu Ala Ser Gln 
1               5                   10                  15      


Lys Val Lys Lys Ile Trp Gln Lys Gln Phe Arg Trp Pro Lys Asn Arg 
            20                  25                  30          


Leu Gln Ile Leu Lys Phe Cys Lys Ala Arg Glu Asp Leu Leu Lys Ile 
        35                  40                  45              


Gln Lys Glu Arg Asp Phe His Arg Met His His Lys Arg Ile Val Gln 
    50                  55                  60                  


Glu Lys Asn Lys Leu Ile Asn Asp Leu Lys Gly Leu Lys Leu His Tyr 
65                  70                  75                  80  


Ala Ser Tyr Glu Pro Thr Ile Arg Val Leu His Glu Lys His His Thr 
                85                  90                  95      


Leu Leu Lys Glu Lys Met Leu Thr Ser Leu Glu Arg Asp Lys Val Val 
            100                 105                 110         


Gly Gln Ile Ser Gly Leu Gln Glu Thr Leu Lys Lys Leu Gln Arg Gly 
        115                 120                 125             


His Ser Tyr His Gly Pro Gln Ile Lys Val Asp His Ser Arg Glu Lys 
    130                 135                 140                 


Glu Asn Ala Pro Glu Gly Pro Thr Gln Lys Gly Leu Arg Glu Ala Arg 
145                 150                 155                 160 


Glu Gln Asn Lys Cys Lys Thr Lys Met Lys Gly Asn Thr Lys Asp Ser 
                165                 170                 175     


Glu Phe Pro Ile Asp Met Gln Pro Asn Pro Asn Leu Asn Val Ser Lys 
            180                 185                 190         


Glu Ser Leu Ser Pro Ala Lys Phe Asp Tyr Lys Leu Lys Asn Ile Phe 
        195                 200                 205             


Arg Leu His Glu Leu Pro Val Ser Cys Val Ser Met Gln Pro His Lys 
    210                 215                 220                 


Asp Ile Leu Val Ser Cys Gly Glu Asp Arg Leu Trp Lys Val Leu Gly 
225                 230                 235                 240 


Leu Pro Lys Cys Asn Val Leu Leu Thr Gly Phe Gly His Thr Asp Trp 
                245                 250                 255     


Leu Ser Asp Cys Cys Phe His Pro Ser Gly Asp Lys Leu Ala Thr Ser 
            260                 265                 270         


Ser Gly Asp Thr Thr Val Lys Leu Trp Asp Leu Cys Lys Gly Asp Cys 
        275                 280                 285             


Ile Leu Thr Phe Glu Gly His Ser Arg Ala Val Trp Ser Cys Thr Trp 
    290                 295                 300                 


His Ser Cys Gly Asn Phe Val Ala Ser Ser Ser Leu Asp Lys Thr Ser 
305                 310                 315                 320 


Lys Ile Trp Asp Val Asn Ser Glu Arg Cys Arg Cys Thr Leu Tyr Gly 
                325                 330                 335     


His Thr Asp Ser Val Asn Ser Ile Glu Phe Phe Pro Phe Ser Asn Thr 
            340                 345                 350         


Leu Leu Thr Ser Ser Ala Asp Lys Thr Leu Ser Ile Trp Asp Ala Arg 
        355                 360                 365             


Thr Gly Ile Cys Glu Gln Ser Leu Tyr Gly His Met His Ser Ile Asn 
    370                 375                 380                 


Asp Ala Ile Phe Asp Pro Arg Gly His Met Ile Ala Ser Cys Asp Ala 
385                 390                 395                 400 


Cys Gly Val Thr Lys Leu Trp Asp Phe Arg Lys Leu Leu Pro Ile Val 
                405                 410                 415     


Ser Ile Asp Ile Gly Pro Ser Pro Gly Asn Glu Val Asn Phe Asp Ser 
            420                 425                 430         


Ser Glu Asn Thr Thr Tyr Leu Tyr Arg Leu Gly Ala Gln Ile Tyr Tyr 
        435                 440                 445             


Phe Gln Leu Ser 
    450         

<210>  1520
<211>  817
<212>  DNA
<213>  Homo sapiens

<400>  1520
cacctggctg tccatggcaa aagtgggtgg ggtcatgtgc agcctcctgc cacctgagtg     60

tttcccggga catcaggagg ctgtatcctg cagctgaatt tacacagaag tggaacaact    120

gggctggaag ctctatgaaa gatgcagatg tactttgtat ggacatacag attctgtgaa    180

cagcattgag ttttttcctt tctccaatac tcttctcaca agctctgcag acaagaccct    240

gtctatatgg gatgcaagaa caggtatatg tgagcagtca ctttatggtc acatgcattc    300

tatcaatgat gccatttttg atcccagggg tcacatgata gcatcctgtg atgcctgtgg    360

ggttacaaag ctgtgggact ttcggaagct gttaccaatt gtgtccatcg atataggtcc    420

aagtcctggc aatgaggtga attttgattc atcaggtcga gttttagctc aggcaagtgg    480

caatggtgtt atccatttgc tagatcttaa atctggggag attcacaaat tgatgggcca    540

cgaaaacgag gcacacacgg ttgtgttttc tcacgacggg gagattctct tttctggagg    600

ctctgacggc acagttcgaa cgtggtcttg accgtcagca catcccgctg cagagggcat    660

tccctttaag gcttgaaaat gcctcctgta gtcccaaacc agcaaagaac tggttaaatg    720

tgccagcagg taacatttac agtctgcttt aaaacatgct ttggacatat attttagtgc    780

tcatactgtt actaataaaa aaataacttt atgctca                             817


<210>  1521
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  1521


Met His Ser Ile Asn Asp Ala Ile Phe Asp Pro Arg Gly His Met Ile 
1               5                   10                  15      


Ala Ser Cys Asp Ala Cys Gly Val Thr Lys Leu Trp Asp Phe Arg Lys 
            20                  25                  30          


Leu Leu Pro Ile Val Ser Ile Asp Ile Gly Pro Ser Pro Gly Asn Glu 
        35                  40                  45              


Val Asn Phe Asp Ser Ser Gly Arg Val Leu Ala Gln Ala Ser Gly Asn 
    50                  55                  60                  


Gly Val Ile His Leu Leu Asp Leu Lys Ser Gly Glu Ile His Lys Leu 
65                  70                  75                  80  


Met Gly His Glu Asn Glu Ala His Thr Val Val Phe Ser His Asp Gly 
                85                  90                  95      


Glu Ile Leu Phe Ser Gly Gly Ser Asp Gly Thr Val Arg Thr Trp Ser 
            100                 105                 110         

<210>  1522
<211>  532
<212>  DNA
<213>  Homo sapiens

<400>  1522
ggacagaggc ataaccttgc gtggcagctg cacgggaatt ggatttggct caggtgtttc     60

agatgactaa gttgggagca tttgacaatt ttagatgtgg gatgaaaatt gccttatcta    120

agacataggg cacctgcaga agtaaagaga aacagaacaa aggggaccac tcttggtata    180

gaagttcatc tcgtcgggag catctgtggt tcttttataa gcaatgtaca ttctacaata    240

gaggcagacc cagaaataat tcagatattg gagttagaag atcaggattc taaaaaaacc    300

aaaagatcct gccttactat gcacctatgg cccttcaaag gcgagagtag aatctgctat    360

gatttagaag caagcaataa aaagtacaca tcaggcaatg gaaataatga acaaaattct    420

ctcaagcaag attggcccta tgaacaagtg aagatggtgg gcgatttcag ctgcttcaga    480

atcactctac ctgtctcaag gacaaaggga agaaacccac aatactagat gt            532


<210>  1523
<211>  69
<212>  PRT
<213>  Homo sapiens

<400>  1523


Met His Leu Trp Pro Phe Lys Gly Glu Ser Arg Ile Cys Tyr Asp Leu 
1               5                   10                  15      


Glu Ala Ser Asn Lys Lys Tyr Thr Ser Gly Asn Gly Asn Asn Glu Gln 
            20                  25                  30          


Asn Ser Leu Lys Gln Asp Trp Pro Tyr Glu Gln Val Lys Met Val Gly 
        35                  40                  45              


Asp Phe Ser Cys Phe Arg Ile Thr Leu Pro Val Ser Arg Thr Lys Gly 
    50                  55                  60                  


Arg Asn Pro Gln Tyr 
65                  

<210>  1524
<211>  1033
<212>  DNA
<213>  Homo sapiens

<400>  1524
taaggatact gaggaccttt ggaggtcctc atccaaaggt cttgctgtat tcctcattgg     60

aagatgtaag tgagacagag aaaggacaga ggcagggagc catgacaagg caacttcagg    120

gccaagaaga aactgtcatg aaaagagtga taggatggag aatattggag gatgagctac    180

agttcccaaa aattaagaat gttcccaaag aatgatggag acatttcaaa aggatacgga    240

agccagattg tgggcgcttc tactggccaa ctctgggaca tcgtggacat caaaataaat    300

ttgtaataat aaaggattat agcctattag ttaaatcaga aaaatctgat ttaactaaat    360

gagtaggagg aaaagaaagc tcttccttat attagaaagt caattaataa atgcagaaag    420

gaatgaaaaa attagaaaag ccaccatttg gcaaccatgg caggcagaat ggggagtatg    480

cctccagaca gtaattcctt tcaaactggt ttataggaac tcactgagct tgctgatcga    540

cctctgagag gcaaagtttc tgaattatga agtactgatt atataaactt agacagagac    600

atgcttcatt atttaatagg actgtgtcaa aagcctacta ttaggatgat gtgttgggtg    660

tggaacaggg tctcttcctg ccaggaacac tggtgatttc actccgtgtt caggctgatc    720

tttgaagttg aagacaagca gaagaatcct tctaaaattt agccatgccc ataggctggg    780

agggacactg ctccattcag aggcagcaaa gcacattact gtatctccta tagagctttg    840

agcagtccag tgtacatgga gaaacttagt aaatgttgtt gaattagtga atgaacaaat    900

caatggacca agtcaggggt aagtcttaca tttgtcatct aggtgattaa gaaaggaaaa    960

agtatctgtt tcaagaggat tacaatctaa ctgtactcca atagtaaaat ttactctttt   1020

ggaatctgaa gac                                                      1033


<210>  1525
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  1525


Met Ser Tyr Ser Ser Gln Lys Leu Arg Met Phe Pro Lys Asn Asp Gly 
1               5                   10                  15      


Asp Ile Ser Lys Gly Tyr Gly Ser Gln Ile Val Gly Ala Ser Thr Gly 
            20                  25                  30          


Gln Leu Trp Asp Ile Val Asp Ile Lys Ile Asn Leu 
        35                  40                  

<210>  1526
<211>  993
<212>  DNA
<213>  Homo sapiens

<400>  1526
caagtggcag gaaagtggga gccacctcta ggacctgagg attaaagtca gtaagagctg     60

ggacctcact catgcagact cgaggacatg aattcgacca acaacttgaa tgagcttgga    120

agtggattct tccctagtcc agtcttcaga aattaagaat gttcccaaag aatgatggag    180

acatttcaaa aggatacgga agccagattg tgggcgcttc tactggccaa ctctgggaca    240

tcgtggacat caaaataaat ttgtaataat aaaggattat agcctattag ttaaatcaga    300

aaaatctgat ttaactaaat gagtaggagg aaaagaaagc tcttccttat attagaaagt    360

caattaataa atgcagaaag gaatgaaaaa attagaaaag ccaccatttg gcaaccatgg    420

caggcagaat ggggagtatg cctccagaca gtaattcctt tcaaactggt ttataggaac    480

tcactgagct tgctgatcga cctctgagag gcaaagtttc tgaattatga agtactgatt    540

atataaactt agacagagac atgcttcatt atttaatagg actgtgtcaa aagcctacta    600

ttaggatgat gtgttgggtg tggaacaggg tctcttcctg ccaggaacac tggtgatttc    660

actccgtgtt caggctgatc tttgaagttg aagacaagca gaagaatcct tctaaaattt    720

agccatgccc ataggctggg agggacactg ctccattcag aggcagcaaa gcacattact    780

gtatctccta tagagctttg agcagtccag tgtacatgga gaaacttagt aaatgttgtt    840

gaattagtga atgaacaaat caatggacca agtcaggggt aagtcttaca tttgtcatct    900

aggtgattaa gaaaggaaaa agtatctgtt tcaagaggat tacaatctaa ctgtactcca    960

atagtaaaat ttactctttt ggaatctgaa gac                                 993


<210>  1527
<211>  62
<212>  PRT
<213>  Homo sapiens

<400>  1527


Met Ser Arg Arg Lys Arg Lys Leu Phe Leu Ile Leu Glu Ser Gln Leu 
1               5                   10                  15      


Ile Asn Ala Glu Arg Asn Glu Lys Ile Arg Lys Ala Thr Ile Trp Gln 
            20                  25                  30          


Pro Trp Gln Ala Glu Trp Gly Val Cys Leu Gln Thr Val Ile Pro Phe 
        35                  40                  45              


Lys Leu Val Tyr Arg Asn Ser Leu Ser Leu Leu Ile Asp Leu 
    50                  55                  60          

<210>  1528
<211>  1706
<212>  DNA
<213>  Homo sapiens

<400>  1528
cttcatggac acccacacag attcactgga gagcaaagcc taccagagtc cctgtcagca     60

gcactgtttc tagaagcttc cacatgagca gacagcatgg agtcctgggg gctaatgaag    120

cagcaatgtc agcatgagca caggcaggga gaggcaagag gagcagagta aaggggaacg    180

ttctcttcat tcttccacct gcctgtcccc cagccgacac gtcccttccg ttccctgcaa    240

ggccatttcc agggaggctt acgaagacag cagatgatgg tgatggaagg agtctgggtg    300

ctgagctgtg ccatggacct ggaagaagac attcctcaca caagacctca caatcatatc    360

catggaatta tagcactggg ctctccagat ggtgctacag gaagacctcc agaaatttga    420

caatcctcta ttcaaggccc taccacagag acacacagga acggaactca gaatcacaaa    480

caaagaaact ttgatccaag aaagaaaatg atctttaaaa agaccctcgt ttcatgctgg    540

ccgatgctga gaaaatctgc tctgaaggat atttggagac actgattaaa aggtagtacc    600

atcaccacat atttaacttc cccctctttt tcctctgctt ctaggagtag agaaaccaac    660

aaaaccaacc ggagagagat ggtttcaaac aatctgtccc ccaccccacc actattcaca    720

cctttcacaa gggcccagcc acaaagccag tgcaacatga catcaatcat cagcaaagtg    780

gagatggttg tcccagtgga gggggattct tcgtgttacg tagataggaa gcacgatgca    840

aaagtgttga agcaggagtg taaagaataa ttaaaacacc tgcccaagac ccaagcaagg    900

ataggatttc ccagacattc gtgagggaga aaatgccatg tcctttcctt ctggtgtcac    960

atcagaatct gaaggctgct agagaaggga gagaaacatg aaagtgagtc ccatgctgat   1020

tgttgttgaa atacctggaa agaaactggc aaagactatc caagggatgc taagacatgt   1080

ccgaacttac aaaacagtag aacctgaata ggaatttgaa gttgtctata ctctcctcag   1140

ccacaccctg ccattttaca gctagtttgt atgcctggaa gagctgctat atgggatcag   1200

aaagaaaaat aaggtggcag gcagaatggg gagtatgcct ccagacagta attcctttca   1260

aactggttta taggaactca ctgagcttgc tgatcgacct ctgagaggca aagtttctga   1320

attatgaagt actgattata taaacttaga cagagacatg cttcattatt taataggact   1380

gtgtcaaaag cctactatta ggatgatgtg ttgggtgtgg aacagggtct cttcctgcca   1440

ggaacactgg tgatttcact ccgtgttcag gctgatcttt gaagttgaag acaagcagaa   1500

gaatccttct aaaatttagc catgcccata ggctgggagg gacactgctc cattcagagg   1560

cagcaaagca gaacaaatca atggaccaag tcaggggtaa gtcttacatt tgtcatctag   1620

gtgattaaga aaggaaaaag tatctgtttc aagaggatta caatctaact gtactccaat   1680

agtaaaattt actcttttgg aatctg                                        1706


<210>  1529
<211>  63
<212>  PRT
<213>  Homo sapiens

<400>  1529


Met Val Ser Asn Asn Leu Ser Pro Thr Pro Pro Leu Phe Thr Pro Phe 
1               5                   10                  15      


Thr Arg Ala Gln Pro Gln Ser Gln Cys Asn Met Thr Ser Ile Ile Ser 
            20                  25                  30          


Lys Val Glu Met Val Val Pro Val Glu Gly Asp Ser Ser Cys Tyr Val 
        35                  40                  45              


Asp Arg Lys His Asp Ala Lys Val Leu Lys Gln Glu Cys Lys Glu 
    50                  55                  60              

<210>  1530
<211>  1515
<212>  DNA
<213>  Homo sapiens

<400>  1530
agtgtaggat gttagaaata catgagtgtt tcctcgaact ggaaaaaacc ccacttaatt     60

tattatttta tgaaaagatt caccttgggg cccattaaag agctcctttt gtatatttaa    120

aatagatttt gaattaccaa aaccttaaga attactctgt ctctttaagg gatctgcttt    180

agggctaagg catattggga tttatgactc taagagtggt attaaaatat tcaactgaat    240

gttagctgat atgtttcctt ccccacccca ggctgcaact ttcccagggg atctgaagcc    300

tgtagcacat tgggctgtag agattttaac ttcccagttc taataggttt ccagatggaa    360

aattatattt ctttctggga gagattaatg agcgaacaac aatggtgtca tggttaattt    420

tatgtgtcaa cttggttagg ttatgatgcc tagttgtttg gtcaaacccc actgtggatg    480

tggctatgaa tgtatttgtg ggtgtgatta acatttaaat cagtagactt tgactaaagc    540

agattccttt actcaaataa tgcaggttaa tgtgggtaag tctcatccaa tcctttgaag    600

gcctgaagaa caaagagtga ggtttctgga agaagaaaat tttacctcaa gcctgcaatg    660

tagaaattct gcttgagttt cccgcctgct ggcctgccct gtggaattcg gagtcaagaa    720

ggagtcttgt aagcattaac tgagatagta tatgaagagt gcttttgcac cgagtgaacc    780

ttcaatcaac tgtactagtt tgtatgcctg gaagagctgc tatatgggat cagaaagaaa    840

aataaggtat ggtgattgct cattaggtga aaagtacagc ctggtcaggg ggcactcagt    900

gatcacctgt gggtgtcatt gtatggactt gcctcctatg tccaacacag tgaggatgcg    960

tcatctctag aaaagggaga tttagtcagg tgagagccac atcagtacag taatatttta   1020

aagggctgag gaaaaaggta gaacatgtag aaaataattc ctttttccat tcctatcacc   1080

agcagcacac ccacattccc gtattctaat gatactcaaa aatccagagt gggagatttg   1140

cttagtaata gagtcaacat ggtgttgtta tggaaaaata ttttgttcaa tcagcaaaaa   1200

tcacttgtca gttaagcctc tggaaccatg atccggttac tgattgacac tgagtaatgt   1260

ttctcttggg cttctggaca agatctgagc tgcagagtag ggcagtcatg taaatgtgcc   1320

taattggtca gggtgaaaag ctgtgagcac tcaatctgtc ctggggttta ggcttgccca   1380

agggcaatta taggcaaatt aaaggacaat tttgtagata aatgacatca ggagtacata   1440

acacttgtct ggtaacactt gtctggtaac acttgactaa taacacctac tctgtatcaa   1500

agcacaagat ggata                                                    1515


<210>  1531
<211>  72
<212>  PRT
<213>  Homo sapiens

<400>  1531


Met Lys Ser Ala Phe Ala Pro Ser Glu Pro Ser Ile Asn Cys Thr Ser 
1               5                   10                  15      


Leu Tyr Ala Trp Lys Ser Cys Tyr Met Gly Ser Glu Arg Lys Ile Arg 
            20                  25                  30          


Tyr Gly Asp Cys Ser Leu Gly Glu Lys Tyr Ser Leu Val Arg Gly His 
        35                  40                  45              


Ser Val Ile Thr Cys Gly Cys His Cys Met Asp Leu Pro Pro Met Ser 
    50                  55                  60                  


Asn Thr Val Arg Met Arg His Leu 
65                  70          

<210>  1532
<211>  3240
<212>  DNA
<213>  Homo sapiens

<400>  1532
agagcccagc gtgcgcggcc ttgcgtgcgt gcacacgcat atgtgtccag gtgcctacgc     60

aggtgcctga ccctgggcaa gtcgctccgt catgcggacc tcagttttct catctgtccg    120

acgaagcatg attttctggt cagactgcat cagctccctc ttctccacca ggacagtagg    180

gatctacagc ccaagaacca aagactttgg acattttgtt ctacttggga agtttgtaat    240

gttatcttct gctgtggagc atagtgcaaa gaaatagggg gaagaaaggt gggtttcttc    300

tgtctccacc ccaaagacca aggatacttt cttccctgag ggttgcctct gcattgcaag    360

ttttttctga cccttcacta cacagatgga caactcaggt ggccagagga cttcaactga    420

atggaattac acaatgattt gttgaacatg tattgtgcac cagggagtat gtgaggctat    480

gtggtaggca tgagatgaac aatggaagat tcttgcccca tggaaggtga ccactggaat    540

tagaaatcct agcatcacct aaggaaaggc tcagatcttc cctggtggag gttggggatc    600

ttcccgaagg gaccttttgg acccagagct cttgtatcat tgcctcttgg caagaggttt    660

agagactccc ttcatcatga agtttcacag actccttcag cctttatctt tcctgagttc    720

tatggggaaa agctaggtta gatatgtgga gtgactcacc gagacctgag aaggcatctg    780

catgaggctg cgggggtgtc cttagagaaa agggaagctg cagtgtggag gctgggggat    840

gcacaagatg atctccagag tctctcagcc ttcagaagcg caggctctct gaggccacat    900

tccttcctgg tctggctcag tggaggctgt gtttccccac tgttgctttt tgcatggatt    960

tgttcagcag ttgaatgggc agagaaggag gagtctctcc cttcctgttc tcacacagct   1020

ctgcttcatg gacacccaca cagattcact ggagagcaaa gcctaccaga gtccctgtca   1080

gcagcactgt ttctagaagc ttccacatga gcagacagca tggagtcctg ggggctaatg   1140

aagcagcaat gtcagcatga gcacaggcag ggagaggcaa gaggagcaga gtaaagggga   1200

acgttctctt cattcttcca cctgcctgtc ccccagccga cacgtccctt ccgttccctg   1260

caaggccatt tccagggagg cttacgaaga cagcagatga tggtgatgga aggagtctgg   1320

gtgctgagct gtgccatgga cctggagaga aactgagtcc gagggatgtc aacatgccaa   1380

gtccatggaa atatcagtgg gctggaattc tagctgcctg aaagaagaca ttcctcacac   1440

aagacctcac aatcatatcc atggaattat agcactgggc tctccagatg gtgctacagg   1500

aagacctcca gaaatttgac aatcctctat tcaaggccct accacagaga cacacaggaa   1560

cggaactcag aatcacaaac aaagaaactt tgatccaaga aagaaaatga tctttaaaaa   1620

gaccctcgtt tcatgctggc cgatgctgag aaaatctgct ctgaaggata tttggagaca   1680

ctgattaaaa gatggttgtc ccagtggagg gggattcttc gtgttacgta gataggaagc   1740

acgatgcaaa agtgttgaag caggagtgta aagaataatt aaaacacctg cccaagaccc   1800

aagcaaggat aggatttccc agacattcgt gagggagaaa atgccatgtc ctttccttct   1860

ggtgtcacat cagaatctga aggctgctag agaagggaga gaaacatgaa agtgagtccc   1920

atgctgattg ttgttgaaat acctggaaag aaactggcaa agactatcca agggatgcta   1980

agacatgtcc gaacttacaa aacagtagaa cctgaatagg aatttgaagt tgtctatact   2040

ctcctcagcc acaccctgcc attttacaga ttgtcttctc tggggaagtt agctgtcatg   2100

ttgtgaggat actcaagcag tttataaaga ggttcatgtc gcaaggaatg gaggcctcct   2160

gccaacagcc atgtaaagga gccatctagg aaatagattc tccagcccca gtcagacctt   2220

cagatgatta cagcccctac caaccttctg actgcggtgg aaggaaggtt ccggaaccag   2280

aaccacccag gttaatgtgg gtaagtctca tccaatcctt tgaaggcctg aagaacaaag   2340

agtgaggttt ctggaagaag aaaattttac ctcaagcctg caatgtagaa attctgcttg   2400

agtttcccgc ctgctggcct gccctgtgga attcggagtc aagaaggagt cttgtaagca   2460

ttaactgaga tagtatatga agagtgcttt tgcaccgagt gaaccttcaa tcaactgtac   2520

tagtttgtat gcctggaaga gctgctatat gggatcagaa agaaaaataa ggtatggtga   2580

ttgctcatta ggtgaaaagt acagcctggt cagggggcac tcagtgatca cctgtgggtg   2640

tcattgtatg gacttgcctc ctatgtccaa cacagtgagg atgcgtcatc tctagaaaag   2700

ggagatttag tcaggtgaga gccacatcag tacagtaata ttttaaaggg ctgaggaaaa   2760

aggtagaaca tgtagaaaat aattcctttt tccattccta tcaccagcag cacacccaca   2820

ttcccgtatt ctaatgatac tcaaaaatcc agagtgggag atttgcttag taatagagtc   2880

aacatggtgt tgttatggaa aaatattttg ttcaatcagc aaaaatcact tgtcagttaa   2940

gcctctggaa ccatgatccg gttactgatt gacactgagt aatgtttctc ttgggcttct   3000

ggacaagatc tgagctgcag agtagggcag tcatgtaaat gtgcctaatt ggtcagggtg   3060

aaaagctgtg agcactcaat ctgtcctggg gtttaggctt gcccaagggc aattataggc   3120

aaattaaagg acaattttgt agataaatga catcaggagt acataacact tgtctggtaa   3180

cacttgtctg gtaacacttg actaataaca cctactctgt atcaaagcac aagatggata   3240


<210>  1533
<211>  61
<212>  PRT
<213>  Homo sapiens

<400>  1533


Met Arg Thr Ser Val Phe Ser Ser Val Arg Arg Ser Met Ile Phe Trp 
1               5                   10                  15      


Ser Asp Cys Ile Ser Ser Leu Phe Ser Thr Arg Thr Val Gly Ile Tyr 
            20                  25                  30          


Ser Pro Arg Thr Lys Asp Phe Gly His Phe Val Leu Leu Gly Lys Phe 
        35                  40                  45              


Val Met Leu Ser Ser Ala Val Glu His Ser Ala Lys Lys 
    50                  55                  60      

<210>  1534
<211>  666
<212>  DNA
<213>  Homo sapiens

<400>  1534
agctccatcc acctctctcc accatccatg gcttcacata gcctcatcaa acttctcgga     60

aagctcaaat ggagagggat ggtgagcagt ggctgaggag tagcagctcc caggaagagc    120

actcttggtg ttgcgatctt tgaatgacgt cttgggctcc atggcgcagc tggacagaca    180

gatgtgtaca gatggacggc cgcagcggtg cagctgcaat gcccagcgga agcagcaatg    240

ttcagcactt cagaagtagc actgccttac ctgggtggca ctggtggcct ctggggcgaa    300

gccgctgggc ctcctgcaac agtgataaag tctccagcaa cctgtgggga aaggccttgc    360

agaagacact ctggaaacag aacaattcag gaggccggcc agcagtgaga ggtcccgcat    420

ccactgaggt gaacaacagt gccgtgggat gtaagttgtt tcaagtatca gatccacaga    480

cattatgtac tgagccacac cacttttgga ctctagaaaa tatataatac atctagtatt    540

gtgggtttct tccctttgtc cttgagacag gtagagtgat tctgaagcag ctgaaatcgc    600

ccaccatctt cacttgttca tagggccaat cttgcttgag agaattttgt tcattatttc    660

cattgc                                                               666


<210>  1535
<211>  127
<212>  PRT
<213>  Homo sapiens

<400>  1535


Met Thr Ser Trp Ala Pro Trp Arg Ser Trp Thr Asp Arg Cys Val Gln 
1               5                   10                  15      


Met Asp Gly Arg Ser Gly Ala Ala Ala Met Pro Ser Gly Ser Ser Asn 
            20                  25                  30          


Val Gln His Phe Arg Ser Ser Thr Ala Leu Pro Gly Trp His Trp Trp 
        35                  40                  45              


Pro Leu Gly Arg Ser Arg Trp Ala Ser Cys Asn Ser Asp Lys Val Ser 
    50                  55                  60                  


Ser Asn Leu Trp Gly Lys Ala Leu Gln Lys Thr Leu Trp Lys Gln Asn 
65                  70                  75                  80  


Asn Ser Gly Gly Arg Pro Ala Val Arg Gly Pro Ala Ser Thr Glu Val 
                85                  90                  95      


Asn Asn Ser Ala Val Gly Cys Lys Leu Phe Gln Val Ser Asp Pro Gln 
            100                 105                 110         


Thr Leu Cys Thr Glu Pro His His Phe Trp Thr Leu Glu Asn Ile 
        115                 120                 125         

<210>  1536
<211>  500
<212>  DNA
<213>  Homo sapiens

<400>  1536
gacacaaacg cccagctgcc cccagttcag tgccacagag aaaagccttg cagaacaggt     60

tgagtttgtg gatgggcatg gggtagaagg tatcatctct tctctatcaa tgacttgggt    120

gatacttctg gcaacaaaac agacagttct cggcctctgt gttttcattg tccaactgaa    180

gattagacaa gaggcagcat ggggtggtgg ataaatcgtg gaccaggatt gaagcgaaga    240

tctgctcatc tgggacactc accagacgga gtcttgctct gtcgcccagg ctggagtaca    300

gaagtacagt ggcgcgatct gcaacctccg tttcctgggt tcaagcaatt cccctgtctc    360

agcctcccga gtagctggga ctacagaccc atgccatcat acccagataa tttttgtatt    420

tttagtagag acaaggtttc accatatcag tcaggctggt ctcgaactcc tgacctcagg    480

tgatccccct gccttggcct                                                500


<210>  1537
<211>  94
<212>  PRT
<213>  Homo sapiens

<400>  1537


Met Gly Trp Trp Ile Asn Arg Gly Pro Gly Leu Lys Arg Arg Ser Ala 
1               5                   10                  15      


His Leu Gly His Ser Pro Asp Gly Val Leu Leu Cys Arg Pro Gly Trp 
            20                  25                  30          


Ser Thr Glu Val Gln Trp Arg Asp Leu Gln Pro Pro Phe Pro Gly Phe 
        35                  40                  45              


Lys Gln Phe Pro Cys Leu Ser Leu Pro Ser Ser Trp Asp Tyr Arg Pro 
    50                  55                  60                  


Met Pro Ser Tyr Pro Asp Asn Phe Cys Ile Phe Ser Arg Asp Lys Val 
65                  70                  75                  80  


Ser Pro Tyr Gln Ser Gly Trp Ser Arg Thr Pro Asp Leu Arg 
                85                  90                  

<210>  1538
<211>  6120
<212>  DNA
<213>  Homo sapiens

<400>  1538
tcggtctccg gctccggcgc cggctcctgc tcctcctggc cgcccggggc caaggcgacg     60

agaggttgta aaaatccatg tgggacggcc ccggggcgag catcggaaag atctctgagt    120

ggagttattt tctggtacgg actgtgaaaa gaatgcggtg aaaattctgg acaatcgtgg    180

aaatattagc tcaaacccca acttaatata gcatttcttc tcttcagtaa cacctcataa    240

tacaagaaaa atgtatggaa gtgcaagaac aatcaccaat ctggaaggta gcccttccag    300

atcccctcgt ttgccaaggt ctcctcgttt gggccaccga agaacaagta gtgggggagg    360

tggaggaaca ggcaagactc tgtctatgga gaatatccag tccctcaatg cagcctatgc    420

tacgtctgga cccatgtatc tgagtgatca tgaaggggtg gcttcaacaa cctacccaaa    480

gggcactatg actctgggaa gggctacaaa tcgagctgta tatggaggcc gtgtcacagc    540

catggggagt agtcccaata ttgcttctgc tggactttcc cacacagatg tcctttcata    600

cacagatcaa catggtgggc tgactggctc atcccatcat caccaccacc aggtcccctc    660

catgttgagg caggtaagag acagcacaat gttagatctt caggcccagc tgaaagaact    720

gcagagagag aatgacctcc tccggaaaga gctagacatc aaggacagca aattgggatc    780

ttccatgaac agtattaaga ctttctggag tcctgagctt aagaaggaga gagtcttgag    840

gaaagaagag gcagcgcgga tgtctgtcct caaggagcag atgagggttt cccatgaaga    900

aaatcagcac ctacagttga caatccaggc ccttcaagat gagctgcgaa cccagagaga    960

cctcaaccac ctcctccagc aagagagtgg caaccgagga gcggagcact tcaccatcga   1020

gctgaccgag gagaacttta ggcggctcca agccgagcat gacaggcagg ctaaggagct   1080

gttccttttg aggaagacat tagaggaaat ggagctgaga attgaaacgc agaaacaaac   1140

cctcaatgcc cgagatgagt caattaaaaa acttcttgag atgttgcaaa gtaaaggctt   1200

gccatccaaa agcctggagg atgacaatga gcgaacgcgg cggatggcag aggctgagtc   1260

tcaggtcagc cacttggaag tgattttaga tcagaaagag aaggaaaaca tacatcttag   1320

agaggaattg caccgaagaa gccaacttca gccggagcca gccaagacga aggctctcca   1380

gactgtcatc gaaatgaagg acacaaaaat cgcttcattg gaacgaaaca taagggatct   1440

tgaggatgag atccagatgt taaaagccaa tggtgtgctg aacactgagg accgcgaaga   1500

agagatcaaa caaattgagg tttacaaaag tcactccaag tttatgaaga ccaagattga   1560

tcagctgaag caggaacttt caaagaaaga gtcggaactt cttgccttac aaacaaagct   1620

tgaaaccctc agcaatcaaa attcagattg caagcaacac attgaagtgc tcaaagagtc   1680

acttactgcc aaagaacaga gggctgccat ccttcagact gaggtagatg cgctgagatt   1740

acgactggaa gaaaaagaat ctttcctcaa taaaaaaaca aaacagctac aggacctcac   1800

agaagagaag gggacactgg ccggtgaaat tcgtgacatg aaagatatgt tagaagtgaa   1860

ggaaagaaaa atcaatgttc ttcagaaaaa gattgaaaac ttgcaagaac aacttaggga   1920

taaagacaag caactgacca acctgaaaga cagagtgaag tccttgcaga cggattccag   1980

taatacagat actgcactgg cgacgctaga ggaagctctg tcagagaagg agagaataat   2040

tgagcgcttg aaagaacagc gagaaagaga tgatcgggaa agactagaag agatagaatc   2100

cttccgaaaa gagaacaaag acctgaaaga gaaggtcaat gctttacagg ctgaactgac   2160

tgagaaagag tctagtttaa ttgacctcaa agaacatgca tcttcattag cctctgcggg   2220

gctgaaaagg gattccaaat taaaatctct agaaatagcc attgaacaaa agaaagagga   2280

atgtagcaaa ttggaagcac agttaaaaaa ggcacataat attgaagatg actccaggat   2340

gaaccctgag tttgcagacc aaataaaaca gctcgataaa gaggcgtctt actaccgcga   2400

cgagtgtggc aaggcccaag cggaagtgga ccggttgctg gagatcctca aggaggtgga   2460

gaatgagaag aatgacaagg acaagaagat cgcagaactg gagaggcata tgaaagatca   2520

gaataagaag gtggccaacc tcaagcacaa tcaacagttg gaaaagaaga aaaatgctca   2580

gttactagaa gaagtgcgca ggcgagaaga cagcatggct gacaactcac agcatttgca   2640

gatagaggaa ctgatgaatg cactggagaa gaccagacag gaactggatg ccaccaaagc   2700

acgcctcgcc tccacacaac agtccctggc cgaaaaagaa gcgcacttgg ccaacctccg   2760

gattgagagg aggaaacagc tggaggagat cctggagatg aaacaggaag cactacttgc   2820

agccatcagt gaaaaagatg caaacattgc cttgctggaa ttgtctgcct ccaaaaagaa   2880

aaagacgcag gaagaagtca tggccctcaa gcgggaaaaa gaccgactag tacatcaatt   2940

aaagcagcag acccagaaca gaatgaagtt gatggcagac aactatgatg atgaccatca   3000

ccattaccac caccaccacc atcaccacca ccatcgatct cctgggaggt cgcaacattc   3060

caatcacagg ccctctccgg accaggatga cgaggagggc atatgggcat agccgggcct   3120

gtaaaccaaa gttccagttt tgttttgagg gctattagaa gggctgaata aagggaacat   3180

gcagctctgc agcaatattc tgataatgta ttgcagtgcg gctcacatca ctgtccacca   3240

ccacctggag cggctcatca gaactgaagg ggagttttca cttaccttat tgagcgtgat   3300

tctgttctac ttgatatttc cttcaccacc tcatgtcatt tctcatggat ttggttatga   3360

tggaaaggaa gaatgcagag gaggagaaaa gtgacagatc ctccattttt gttgggatgc   3420

gggcattttg aatgtgatca tctttgctga atgtcattat ttgataacat tttgtttatg   3480

ttacttaaac atcattggat aaatttgaac tccatgggat tttatctgtg gattcagctt   3540

ctgttggaca actagcctca tctccagtat cctgctggtt cactctaatt ggtcattcct   3600

aatgcattag attatcaaaa agtataaatt cgctgtgagt gagtggtgtt ggcagtgttt   3660

gtataccatg atgcatggag tgtttgacga agaaacaaaa aacaccaaaa attgcgagcc   3720

tttaccctcc tctatttctt taatctgttg tttgaagaac cgcattttga gggtgtaacc   3780

agtagtcacc tctgggccag gttggaaaag aaatcaattt tttaaaccac taatgcttgc   3840

caagaaatcg ccttatgaga acatggtgtg tgtctctgac aatgcgtggc acatctaaat   3900

tgatcattca taattttatc tacccagtca tgtactggag agtggcaaaa gtctgaggca   3960

cctgcatatc tctagtccct gtgttctgca catccccacg gtggggacgc caccaagcct   4020

cagactctta ccatcccggt gcatgcaggt ctccatgaag aagctgggac tcattcacat   4080

ttcaagatcc aaatgctgtg caaacagtgt aagcttagat tttctgtaaa tgaagggtca   4140

tttctctttt tttttttttt taaagaaaat gtgtctgcaa catggattcc aaagcatttt   4200

cagcatcaaa catgaaaaca ttgatgaatg aggaacaatc acaaaagctg tgtctctgta   4260

tatagctcta cacaacatgt atgtggatac agtcattatt taaagcacat gccagggaaa   4320

aagaccaaat tttgaggtct tttacataca gtgatatggt actaaggaga attaaactcc   4380

tactgcttcc tctgaatatt aagaaacaat ttaaattgtt ataacttcat aaaactcatg   4440

actgagtctg gcaaacatgt gcaactcttg tattgctcca ttttcttgtc aatggaagaa   4500

acccttccac gtgtatgcaa gtgggagatg aaaacctgca tttttaaagg acaaacagtg   4560

aatttaagca tgagtggcct taataaatat agttgtcttt ctttgctgct gtggaaagga   4620

ttctaaacag atgtccctga agtcttgcat tgaatttagt cattattatt actttttaaa   4680

atgttggtgc aattaactct ggacctctct tgtgagccat agagatattt aaaagacaaa   4740

caccttattt gtcggggaag atgaaaccgt ccctgagttg caccattctt tcttggtgca   4800

ttcgcggtta agatactcaa gcaggtttct tgcttctggc tttgttcttg tcatcagtaa   4860

gtataacaaa ctatgtaatg cttatgtgtt gcataaacaa tccaaatgca ttcatgtttt   4920

aaaagtttgt cctttaacta tcagagggat ctaggtcttg gttagagaag taagcagagt   4980

tctttgcaag cttatttagc acattttgac acaatgttgc actgaaaacc caggccacaa   5040

atgtgtccca gtgaacagtt tggatgtcct caaagaagtg gttctcactg cctcctacaa   5100

ccaggtcttg acctgaactc tgcaactgaa tacttgaagt aggaagtagg aaatccagta   5160

gggaaaatag ggtccttgaa acagaaaaaa aaaaccaacc catgtatagc tagctatttc   5220

tatgtatgtg ccaattttgt cacagctctt gtttggaggg atcattttct gcccaacttt   5280

cattggttaa aatattactg atcttacctt tatgaggtcg tataatttag tcccttaaaa   5340

attaaattct ctctaacata acaacctttc ccatttcgtg taatattctc tgatgtttgg   5400

gggttaccaa aaatatccct ttttcacata ttaagaatag tctctgggtt tacaacaaac   5460

actgtgatgt tgggaagcta tttcctttgc gcaaacttta acaggttttc ttctaatcat   5520

aacatagttg aaaaaagaag tttgggctaa catttaggag aagttggtct tactttgtgc   5580

aaaagcaggc ttgtgcttta taccccattt gatttcgatg tacagtctca attttgtatt   5640

taatgatttt tgtgtatcca gtatgcacgt taacagcgtg tcaactttca tttgaaagtg   5700

ggtttcaatt tactttttaa acagtgttta tgacgagacc tcagatgtgt tgacgtaagc   5760

tctatctgca atgtttttgt gtagagtggc gattgaatgc tgcccagggt cagtgtatct   5820

aattccccga gaccctcgtt tgatagtgct tcttgtaata tttcttcaag tgagtggcat   5880

gtgggttgtg atattgacca tgtgattatg gacatcgata tgaaaaataa ataaataaaa   5940

ctaaggaacc ctggaaacta ccagtgggca tgtattagcc agtcattgta acctcgtgtc   6000

tagtagaaca atgtacaagg tatgtacagt tcataaattt gttgtcatgt gtatgagaag   6060

tactttgtgc tgatcgcctt atttatattc atcaaataaa ccttgtttct ttctgaagtg   6120


<210>  1539
<211>  953
<212>  PRT
<213>  Homo sapiens

<400>  1539


Met Tyr Gly Ser Ala Arg Thr Ile Thr Asn Leu Glu Gly Ser Pro Ser 
1               5                   10                  15      


Arg Ser Pro Arg Leu Pro Arg Ser Pro Arg Leu Gly His Arg Arg Thr 
            20                  25                  30          


Ser Ser Gly Gly Gly Gly Gly Thr Gly Lys Thr Leu Ser Met Glu Asn 
        35                  40                  45              


Ile Gln Ser Leu Asn Ala Ala Tyr Ala Thr Ser Gly Pro Met Tyr Leu 
    50                  55                  60                  


Ser Asp His Glu Gly Val Ala Ser Thr Thr Tyr Pro Lys Gly Thr Met 
65                  70                  75                  80  


Thr Leu Gly Arg Ala Thr Asn Arg Ala Val Tyr Gly Gly Arg Val Thr 
                85                  90                  95      


Ala Met Gly Ser Ser Pro Asn Ile Ala Ser Ala Gly Leu Ser His Thr 
            100                 105                 110         


Asp Val Leu Ser Tyr Thr Asp Gln His Gly Gly Leu Thr Gly Ser Ser 
        115                 120                 125             


His His His His His Gln Val Pro Ser Met Leu Arg Gln Val Arg Asp 
    130                 135                 140                 


Ser Thr Met Leu Asp Leu Gln Ala Gln Leu Lys Glu Leu Gln Arg Glu 
145                 150                 155                 160 


Asn Asp Leu Leu Arg Lys Glu Leu Asp Ile Lys Asp Ser Lys Leu Gly 
                165                 170                 175     


Ser Ser Met Asn Ser Ile Lys Thr Phe Trp Ser Pro Glu Leu Lys Lys 
            180                 185                 190         


Glu Arg Val Leu Arg Lys Glu Glu Ala Ala Arg Met Ser Val Leu Lys 
        195                 200                 205             


Glu Gln Met Arg Val Ser His Glu Glu Asn Gln His Leu Gln Leu Thr 
    210                 215                 220                 


Ile Gln Ala Leu Gln Asp Glu Leu Arg Thr Gln Arg Asp Leu Asn His 
225                 230                 235                 240 


Leu Leu Gln Gln Glu Ser Gly Asn Arg Gly Ala Glu His Phe Thr Ile 
                245                 250                 255     


Glu Leu Thr Glu Glu Asn Phe Arg Arg Leu Gln Ala Glu His Asp Arg 
            260                 265                 270         


Gln Ala Lys Glu Leu Phe Leu Leu Arg Lys Thr Leu Glu Glu Met Glu 
        275                 280                 285             


Leu Arg Ile Glu Thr Gln Lys Gln Thr Leu Asn Ala Arg Asp Glu Ser 
    290                 295                 300                 


Ile Lys Lys Leu Leu Glu Met Leu Gln Ser Lys Gly Leu Pro Ser Lys 
305                 310                 315                 320 


Ser Leu Glu Asp Asp Asn Glu Arg Thr Arg Arg Met Ala Glu Ala Glu 
                325                 330                 335     


Ser Gln Val Ser His Leu Glu Val Ile Leu Asp Gln Lys Glu Lys Glu 
            340                 345                 350         


Asn Ile His Leu Arg Glu Glu Leu His Arg Arg Ser Gln Leu Gln Pro 
        355                 360                 365             


Glu Pro Ala Lys Thr Lys Ala Leu Gln Thr Val Ile Glu Met Lys Asp 
    370                 375                 380                 


Thr Lys Ile Ala Ser Leu Glu Arg Asn Ile Arg Asp Leu Glu Asp Glu 
385                 390                 395                 400 


Ile Gln Met Leu Lys Ala Asn Gly Val Leu Asn Thr Glu Asp Arg Glu 
                405                 410                 415     


Glu Glu Ile Lys Gln Ile Glu Val Tyr Lys Ser His Ser Lys Phe Met 
            420                 425                 430         


Lys Thr Lys Ile Asp Gln Leu Lys Gln Glu Leu Ser Lys Lys Glu Ser 
        435                 440                 445             


Glu Leu Leu Ala Leu Gln Thr Lys Leu Glu Thr Leu Ser Asn Gln Asn 
    450                 455                 460                 


Ser Asp Cys Lys Gln His Ile Glu Val Leu Lys Glu Ser Leu Thr Ala 
465                 470                 475                 480 


Lys Glu Gln Arg Ala Ala Ile Leu Gln Thr Glu Val Asp Ala Leu Arg 
                485                 490                 495     


Leu Arg Leu Glu Glu Lys Glu Ser Phe Leu Asn Lys Lys Thr Lys Gln 
            500                 505                 510         


Leu Gln Asp Leu Thr Glu Glu Lys Gly Thr Leu Ala Gly Glu Ile Arg 
        515                 520                 525             


Asp Met Lys Asp Met Leu Glu Val Lys Glu Arg Lys Ile Asn Val Leu 
    530                 535                 540                 


Gln Lys Lys Ile Glu Asn Leu Gln Glu Gln Leu Arg Asp Lys Asp Lys 
545                 550                 555                 560 


Gln Leu Thr Asn Leu Lys Asp Arg Val Lys Ser Leu Gln Thr Asp Ser 
                565                 570                 575     


Ser Asn Thr Asp Thr Ala Leu Ala Thr Leu Glu Glu Ala Leu Ser Glu 
            580                 585                 590         


Lys Glu Arg Ile Ile Glu Arg Leu Lys Glu Gln Arg Glu Arg Asp Asp 
        595                 600                 605             


Arg Glu Arg Leu Glu Glu Ile Glu Ser Phe Arg Lys Glu Asn Lys Asp 
    610                 615                 620                 


Leu Lys Glu Lys Val Asn Ala Leu Gln Ala Glu Leu Thr Glu Lys Glu 
625                 630                 635                 640 


Ser Ser Leu Ile Asp Leu Lys Glu His Ala Ser Ser Leu Ala Ser Ala 
                645                 650                 655     


Gly Leu Lys Arg Asp Ser Lys Leu Lys Ser Leu Glu Ile Ala Ile Glu 
            660                 665                 670         


Gln Lys Lys Glu Glu Cys Ser Lys Leu Glu Ala Gln Leu Lys Lys Ala 
        675                 680                 685             


His Asn Ile Glu Asp Asp Ser Arg Met Asn Pro Glu Phe Ala Asp Gln 
    690                 695                 700                 


Ile Lys Gln Leu Asp Lys Glu Ala Ser Tyr Tyr Arg Asp Glu Cys Gly 
705                 710                 715                 720 


Lys Ala Gln Ala Glu Val Asp Arg Leu Leu Glu Ile Leu Lys Glu Val 
                725                 730                 735     


Glu Asn Glu Lys Asn Asp Lys Asp Lys Lys Ile Ala Glu Leu Glu Arg 
            740                 745                 750         


His Met Lys Asp Gln Asn Lys Lys Val Ala Asn Leu Lys His Asn Gln 
        755                 760                 765             


Gln Leu Glu Lys Lys Lys Asn Ala Gln Leu Leu Glu Glu Val Arg Arg 
    770                 775                 780                 


Arg Glu Asp Ser Met Ala Asp Asn Ser Gln His Leu Gln Ile Glu Glu 
785                 790                 795                 800 


Leu Met Asn Ala Leu Glu Lys Thr Arg Gln Glu Leu Asp Ala Thr Lys 
                805                 810                 815     


Ala Arg Leu Ala Ser Thr Gln Gln Ser Leu Ala Glu Lys Glu Ala His 
            820                 825                 830         


Leu Ala Asn Leu Arg Ile Glu Arg Arg Lys Gln Leu Glu Glu Ile Leu 
        835                 840                 845             


Glu Met Lys Gln Glu Ala Leu Leu Ala Ala Ile Ser Glu Lys Asp Ala 
    850                 855                 860                 


Asn Ile Ala Leu Leu Glu Leu Ser Ala Ser Lys Lys Lys Lys Thr Gln 
865                 870                 875                 880 


Glu Glu Val Met Ala Leu Lys Arg Glu Lys Asp Arg Leu Val His Gln 
                885                 890                 895     


Leu Lys Gln Gln Thr Gln Asn Arg Met Lys Leu Met Ala Asp Asn Tyr 
            900                 905                 910         


Asp Asp Asp His His His Tyr His His His His His His His His His 
        915                 920                 925             


Arg Ser Pro Gly Arg Ser Gln His Ser Asn His Arg Pro Ser Pro Asp 
    930                 935                 940                 


Gln Asp Asp Glu Glu Gly Ile Trp Ala 
945                 950             

<210>  1540
<211>  6336
<212>  DNA
<213>  Homo sapiens

<400>  1540
tcggtctccg gctccggcgc cggctcctgc tcctcctggc cgcccggggc caaggcgacg     60

agaggttgta aaaatccatg tgggacggcc ccggggcgag catcggaaag atctctgagt    120

ggagttattt tctggtacgg actgtgaaaa gaatgcggtg aaaattctgg acaatcgtgg    180

aaatattagc tcaaacccca acttaatata gcatttcttc tcttcagtaa cacctcataa    240

tacaagaaaa atgtatggaa gtgcaagaac aatcaccaat ctggaaggta gcccttccag    300

atcccctcgt ttgccaaggt ctcctcgttt gggccaccga agaacaagta gtgggggagg    360

tggaggaaca ggcaagactc tgtctatgga gaatatccag tccctcaatg cagcctatgc    420

tacgtctgga cccatgtatc tgagtgatca tgaaggggtg gcttcaacaa cctacccaaa    480

gggcactatg actctgggaa gggctacaaa tcgagctgta tatggaggcc gtgtcacagc    540

catggggagt agtcccaata ttgcttctgc tggactttcc cacacagatg tcctttcata    600

cacagatcaa catggtgggc tgactggctc atcccatcat caccaccacc aggtcccctc    660

catgttgagg caggtaagag acagcacaat gttagatctt caggcccagc tgaaagaact    720

gcagagagag aatgacctcc tccggaaaga gctagacatc aaggacagca aattgggatc    780

ttccatgaac agtattaaga ctttctggag tcctgagctt aagaaggaga gagtcttgag    840

gaaagaagag gcagcgcgga tgtctgtcct caaggagcag atgagggttt cccatgaaga    900

aaatcagcac ctacagttga caatccaggc ccttcaagat gagctgcgaa cccagagaga    960

cctcaaccac ctcctccagc aagagagtgg caaccgagga gcggagcact tcaccatcga   1020

gctgaccgag gagaacttta ggcggctcca agccgagcat gacaggcagg ctaaggagct   1080

gttccttttg aggaagacat tagaggaaat ggagctgaga attgaaacgc agaaacaaac   1140

cctcaatgcc cgagatgagt caattaaaaa acttcttgag atgttgcaaa gtaaaggctt   1200

gccatccaaa agcctggagg atgacaatga gcgaacgcgg cggatggcag aggctgagtc   1260

tcaggtcagc cacttggaag tgattttaga tcagaaagag aaggaaaaca tacatcttag   1320

agaggaattg caccgaagaa gccaacttca gccggagcca gccaagacga aggctctcca   1380

gactgtcatc gaaatgaagg acacaaaaat cgcttcattg gaacgaaaca taagggatct   1440

tgaggatgag atccagatgt taaaagccaa tggtgtgctg aacactgagg accgcgaaga   1500

agagatcaaa caaattgagg tttacaaaag tcactccaag tttatgaaga ccaagattga   1560

tcagctgaag caggaacttt caaagaaaga gtcggaactt cttgccttac aaacaaagct   1620

tgaaaccctc agcaatcaaa attcagattg caagcaacac attgaagtgc tcaaagagtc   1680

acttactgcc aaagaacaga gggctgccat ccttcagact gaggtagatg cgctgagatt   1740

acgactggaa gaaaaagaat ctttcctcaa taaaaaaaca aaacagctac aggacctcac   1800

agaagagaag gggacactgg ccggtgaaat tcgtgacatg aaagatatgt tagaagtgaa   1860

ggaaagaaaa atcaatgttc ttcagaaaaa gattgaaaac ttgcaagaac aacttaggga   1920

taaagacaag caactgacca acctgaaaga cagagtgaag tccttgcaga cggattccag   1980

taatacagat actgcactgg cgacgctaga ggaagctctg tcagagaagg agagaataat   2040

tgagcgcttg aaagaacagc gagaaagaga tgatcgggaa agactagaag agatagaatc   2100

cttccgaaaa gagaacaaag acctgaaaga gaaggtcaat gctttacagg ctgaactgac   2160

tgagaaagag tctagtttaa ttgacctcaa agaacatgca tcttcattag cctctgcggg   2220

gctgaaaagg gattccaaat taaaatctct agaaatagcc attgaacaaa agaaagagga   2280

atgtagcaaa ttggaagcac agttaaaaaa ggcacataat attgaagatg actccaggat   2340

gaaccctgag tttgcagacc aaataaaaca gctcgataaa gaggcgtctt actaccgcga   2400

cgagtgtggc aaggcccaag cggaagtgga ccggttgctg gagatcctca aggaggtgga   2460

gaatgagaag aatgacaagg acaagaagat cgcagaactg gagaggcata tgaaagatca   2520

gaataagaag gtggccaacc tcaagcacaa tcaacagttg gaaaagaaga aaaatgctca   2580

gttactagaa gaagtgcgca ggcgagaaga cagcatggct gacaactcac agcatttgca   2640

gatagaggaa ctgatgaatg cactggagaa gaccagacag gaactggatg ccaccaaagc   2700

acgcctcgcc tccacacaac agtccctggc cgaaaaagaa gcgcacttgg ccaacctccg   2760

gattgagagg aggaaacagc tggaggagat cctggagatg aaacaggaag cactacttgc   2820

agccatcagt gaaaaagatg caaacattgc cttgctggaa ttgtctgcct ccaaaaagaa   2880

aaagacgcag gaagaagtca tggccctcaa gcgggaaaaa gaccgactag tacatcaatt   2940

aaagcagcag acccagaaca gaatgaagtt gatggcagac aactatgatg atgaccatca   3000

ccattaccac caccaccacc atcaccacca ccatcgatct cctgggaggt cgcaacattc   3060

caatcacagg ccctctccgg accaggatga cgaggagggc atatgggcat agccgggcct   3120

gtaaaccaaa gttccagttt tgttttgagg gatgatccag ctctgtcgga ggcacgtagg   3180

cacagccaaa tctcatgctg tacattgatc acctgtccaa cctttgccta gagtgggagc   3240

ccccagttcc ttcgagatcc aacattacct gtctgtaaag aagaagagga ggagggagac   3300

agcggggagg atccggtggc agtttaacac cagagcaggt ccaatgttta cttttaccct   3360

tttggagcta ttagaagggc tgaataaagg gaacatgcag ctctgcagca atattctgat   3420

aatgtattgc agtgcggctc acatcactgt ccaccaccac ctggagcggc tcatcagaac   3480

tgaaggggag ttttcactta ccttattgag cgtgattctg ttctacttga tatttccttc   3540

accacctcat gtcatttctc atggatttgg ttatgatgga aaggaagaat gcagaggagg   3600

agaaaagtga cagatcctcc atttttgttg ggatgcgggc attttgaatg tgatcatctt   3660

tgctgaatgt cattatttga taacattttg tttatgttac ttaaacatca ttggataaat   3720

ttgaactcca tgggatttta tctgtggatt cagcttctgt tggacaacta gcctcatctc   3780

cagtatcctg ctggttcact ctaattggtc attcctaatg cattagatta tcaaaaagta   3840

taaattcgct gtgagtgagt ggtgttggca gtgtttgtat accatgatgc atggagtgtt   3900

tgacgaagaa acaaaaaaca ccaaaaattg cgagccttta ccctcctcta tttctttaat   3960

ctgttgtttg aagaaccgca ttttgagggt gtaaccagta gtcacctctg ggccaggttg   4020

gaaaagaaat caatttttta aaccactaat gcttgccaag aaatcgcctt atgagaacat   4080

ggtgtgtgtc tctgacaatg cgtggcacat ctaaattgat cattcataat tttatctacc   4140

cagtcatgta ctggagagtg gcaaaagtct gaggcacctg catatctcta gtccctgtgt   4200

tctgcacatc cccacggtgg ggacgccacc aagcctcaga ctcttaccat cccggtgcat   4260

gcaggtctcc atgaagaagc tgggactcat tcacatttca agatccaaat gctgtgcaaa   4320

cagtgtaagc ttagattttc tgtaaatgaa gggtcatttc tctttttttt tttttttaaa   4380

gaaaatgtgt ctgcaacatg gattccaaag cattttcagc atcaaacatg aaaacattga   4440

tgaatgagga acaatcacaa aagctgtgtc tctgtatata gctctacaca acatgtatgt   4500

ggatacagtc attatttaaa gcacatgcca gggaaaaaga ccaaattttg aggtctttta   4560

catacagtga tatggtacta aggagaatta aactcctact gcttcctctg aatattaaga   4620

aacaatttaa attgttataa cttcataaaa ctcatgactg agtctggcaa acatgtgcaa   4680

ctcttgtatt gctccatttt cttgtcaatg gaagaaaccc ttccacgtgt atgcaagtgg   4740

gagatgaaaa cctgcatttt taaaggacaa acagtgaatt taagcatgag tggccttaat   4800

aaatatagtt gtctttcttt gctgctgtgg aaaggattct aaacagatgt ccctgaagtc   4860

ttgcattgaa tttagtcatt attattactt tttaaaatgt tggtgcaatt aactctggac   4920

ctctcttgtg agccatagag atatttaaaa gacaaacacc ttatttgtcg gggaagatga   4980

aaccgtccct gagttgcacc attctttctt ggtgcattcg cggttaagat actcaagcag   5040

gtttcttgct tctggctttg ttcttgtcat cagtaagtat aacaaactat gtaatgctta   5100

tgtgttgcat aaacaatcca aatgcattca tgttttaaaa gtttgtcctt taactatcag   5160

agggatctag gtcttggtta gagaagtaag cagagttctt tgcaagctta tttagcacat   5220

tttgacacaa tgttgcactg aaaacccagg ccacaaatgt gtcccagtga acagtttgga   5280

tgtcctcaaa gaagtggttc tcactgcctc ctacaaccag gtcttgacct gaactctgca   5340

actgaatact tgaagtagga agtaggaaat ccagtaggga aaatagggtc cttgaaacag   5400

aaaaaaaaaa ccaacccatg tatagctagc tatttctatg tatgtgccaa ttttgtcaca   5460

gctcttgttt ggagggatca ttttctgccc aactttcatt ggttaaaata ttactgatct   5520

tacctttatg aggtcgtata atttagtccc ttaaaaatta aattctctct aacataacaa   5580

cctttcccat ttcgtgtaat attctctgat gtttgggggt taccaaaaat atcccttttt   5640

cacatattaa gaatagtctc tgggtttaca acaaacactg tgatgttggg aagctatttc   5700

ctttgcgcaa actttaacag gttttcttct aatcataaca tagttgaaaa aagaagtttg   5760

ggctaacatt taggagaagt tggtcttact ttgtgcaaaa gcaggcttgt gctttatacc   5820

ccatttgatt tcgatgtaca gtctcaattt tgtatttaat gatttttgtg tatccagtat   5880

gcacgttaac agcgtgtcaa ctttcatttg aaagtgggtt tcaatttact ttttaaacag   5940

tgtttatgac gagacctcag atgtgttgac gtaagctcta tctgcaatgt ttttgtgtag   6000

agtggcgatt gaatgctgcc cagggtcagt gtatctaatt ccccgagacc ctcgtttgat   6060

agtgcttctt gtaatatttc ttcaagtgag tggcatgtgg gttgtgatat tgaccatgtg   6120

attatggaca tcgatatgaa aaataaataa ataaaactaa ggaaccctgg aaactaccag   6180

tgggcatgta ttagccagtc attgtaacct cgtgtctagt agaacaatgt acaaggtatg   6240

tacagttcat aaatttgttg tcatgtgtat gagaagtact ttgtgctgat cgccttattt   6300

atattcatca aataaacctt gtttctttct gaagtg                             6336


<210>  1541
<211>  953
<212>  PRT
<213>  Homo sapiens

<400>  1541


Met Tyr Gly Ser Ala Arg Thr Ile Thr Asn Leu Glu Gly Ser Pro Ser 
1               5                   10                  15      


Arg Ser Pro Arg Leu Pro Arg Ser Pro Arg Leu Gly His Arg Arg Thr 
            20                  25                  30          


Ser Ser Gly Gly Gly Gly Gly Thr Gly Lys Thr Leu Ser Met Glu Asn 
        35                  40                  45              


Ile Gln Ser Leu Asn Ala Ala Tyr Ala Thr Ser Gly Pro Met Tyr Leu 
    50                  55                  60                  


Ser Asp His Glu Gly Val Ala Ser Thr Thr Tyr Pro Lys Gly Thr Met 
65                  70                  75                  80  


Thr Leu Gly Arg Ala Thr Asn Arg Ala Val Tyr Gly Gly Arg Val Thr 
                85                  90                  95      


Ala Met Gly Ser Ser Pro Asn Ile Ala Ser Ala Gly Leu Ser His Thr 
            100                 105                 110         


Asp Val Leu Ser Tyr Thr Asp Gln His Gly Gly Leu Thr Gly Ser Ser 
        115                 120                 125             


His His His His His Gln Val Pro Ser Met Leu Arg Gln Val Arg Asp 
    130                 135                 140                 


Ser Thr Met Leu Asp Leu Gln Ala Gln Leu Lys Glu Leu Gln Arg Glu 
145                 150                 155                 160 


Asn Asp Leu Leu Arg Lys Glu Leu Asp Ile Lys Asp Ser Lys Leu Gly 
                165                 170                 175     


Ser Ser Met Asn Ser Ile Lys Thr Phe Trp Ser Pro Glu Leu Lys Lys 
            180                 185                 190         


Glu Arg Val Leu Arg Lys Glu Glu Ala Ala Arg Met Ser Val Leu Lys 
        195                 200                 205             


Glu Gln Met Arg Val Ser His Glu Glu Asn Gln His Leu Gln Leu Thr 
    210                 215                 220                 


Ile Gln Ala Leu Gln Asp Glu Leu Arg Thr Gln Arg Asp Leu Asn His 
225                 230                 235                 240 


Leu Leu Gln Gln Glu Ser Gly Asn Arg Gly Ala Glu His Phe Thr Ile 
                245                 250                 255     


Glu Leu Thr Glu Glu Asn Phe Arg Arg Leu Gln Ala Glu His Asp Arg 
            260                 265                 270         


Gln Ala Lys Glu Leu Phe Leu Leu Arg Lys Thr Leu Glu Glu Met Glu 
        275                 280                 285             


Leu Arg Ile Glu Thr Gln Lys Gln Thr Leu Asn Ala Arg Asp Glu Ser 
    290                 295                 300                 


Ile Lys Lys Leu Leu Glu Met Leu Gln Ser Lys Gly Leu Pro Ser Lys 
305                 310                 315                 320 


Ser Leu Glu Asp Asp Asn Glu Arg Thr Arg Arg Met Ala Glu Ala Glu 
                325                 330                 335     


Ser Gln Val Ser His Leu Glu Val Ile Leu Asp Gln Lys Glu Lys Glu 
            340                 345                 350         


Asn Ile His Leu Arg Glu Glu Leu His Arg Arg Ser Gln Leu Gln Pro 
        355                 360                 365             


Glu Pro Ala Lys Thr Lys Ala Leu Gln Thr Val Ile Glu Met Lys Asp 
    370                 375                 380                 


Thr Lys Ile Ala Ser Leu Glu Arg Asn Ile Arg Asp Leu Glu Asp Glu 
385                 390                 395                 400 


Ile Gln Met Leu Lys Ala Asn Gly Val Leu Asn Thr Glu Asp Arg Glu 
                405                 410                 415     


Glu Glu Ile Lys Gln Ile Glu Val Tyr Lys Ser His Ser Lys Phe Met 
            420                 425                 430         


Lys Thr Lys Ile Asp Gln Leu Lys Gln Glu Leu Ser Lys Lys Glu Ser 
        435                 440                 445             


Glu Leu Leu Ala Leu Gln Thr Lys Leu Glu Thr Leu Ser Asn Gln Asn 
    450                 455                 460                 


Ser Asp Cys Lys Gln His Ile Glu Val Leu Lys Glu Ser Leu Thr Ala 
465                 470                 475                 480 


Lys Glu Gln Arg Ala Ala Ile Leu Gln Thr Glu Val Asp Ala Leu Arg 
                485                 490                 495     


Leu Arg Leu Glu Glu Lys Glu Ser Phe Leu Asn Lys Lys Thr Lys Gln 
            500                 505                 510         


Leu Gln Asp Leu Thr Glu Glu Lys Gly Thr Leu Ala Gly Glu Ile Arg 
        515                 520                 525             


Asp Met Lys Asp Met Leu Glu Val Lys Glu Arg Lys Ile Asn Val Leu 
    530                 535                 540                 


Gln Lys Lys Ile Glu Asn Leu Gln Glu Gln Leu Arg Asp Lys Asp Lys 
545                 550                 555                 560 


Gln Leu Thr Asn Leu Lys Asp Arg Val Lys Ser Leu Gln Thr Asp Ser 
                565                 570                 575     


Ser Asn Thr Asp Thr Ala Leu Ala Thr Leu Glu Glu Ala Leu Ser Glu 
            580                 585                 590         


Lys Glu Arg Ile Ile Glu Arg Leu Lys Glu Gln Arg Glu Arg Asp Asp 
        595                 600                 605             


Arg Glu Arg Leu Glu Glu Ile Glu Ser Phe Arg Lys Glu Asn Lys Asp 
    610                 615                 620                 


Leu Lys Glu Lys Val Asn Ala Leu Gln Ala Glu Leu Thr Glu Lys Glu 
625                 630                 635                 640 


Ser Ser Leu Ile Asp Leu Lys Glu His Ala Ser Ser Leu Ala Ser Ala 
                645                 650                 655     


Gly Leu Lys Arg Asp Ser Lys Leu Lys Ser Leu Glu Ile Ala Ile Glu 
            660                 665                 670         


Gln Lys Lys Glu Glu Cys Ser Lys Leu Glu Ala Gln Leu Lys Lys Ala 
        675                 680                 685             


His Asn Ile Glu Asp Asp Ser Arg Met Asn Pro Glu Phe Ala Asp Gln 
    690                 695                 700                 


Ile Lys Gln Leu Asp Lys Glu Ala Ser Tyr Tyr Arg Asp Glu Cys Gly 
705                 710                 715                 720 


Lys Ala Gln Ala Glu Val Asp Arg Leu Leu Glu Ile Leu Lys Glu Val 
                725                 730                 735     


Glu Asn Glu Lys Asn Asp Lys Asp Lys Lys Ile Ala Glu Leu Glu Arg 
            740                 745                 750         


His Met Lys Asp Gln Asn Lys Lys Val Ala Asn Leu Lys His Asn Gln 
        755                 760                 765             


Gln Leu Glu Lys Lys Lys Asn Ala Gln Leu Leu Glu Glu Val Arg Arg 
    770                 775                 780                 


Arg Glu Asp Ser Met Ala Asp Asn Ser Gln His Leu Gln Ile Glu Glu 
785                 790                 795                 800 


Leu Met Asn Ala Leu Glu Lys Thr Arg Gln Glu Leu Asp Ala Thr Lys 
                805                 810                 815     


Ala Arg Leu Ala Ser Thr Gln Gln Ser Leu Ala Glu Lys Glu Ala His 
            820                 825                 830         


Leu Ala Asn Leu Arg Ile Glu Arg Arg Lys Gln Leu Glu Glu Ile Leu 
        835                 840                 845             


Glu Met Lys Gln Glu Ala Leu Leu Ala Ala Ile Ser Glu Lys Asp Ala 
    850                 855                 860                 


Asn Ile Ala Leu Leu Glu Leu Ser Ala Ser Lys Lys Lys Lys Thr Gln 
865                 870                 875                 880 


Glu Glu Val Met Ala Leu Lys Arg Glu Lys Asp Arg Leu Val His Gln 
                885                 890                 895     


Leu Lys Gln Gln Thr Gln Asn Arg Met Lys Leu Met Ala Asp Asn Tyr 
            900                 905                 910         


Asp Asp Asp His His His Tyr His His His His His His His His His 
        915                 920                 925             


Arg Ser Pro Gly Arg Ser Gln His Ser Asn His Arg Pro Ser Pro Asp 
    930                 935                 940                 


Gln Asp Asp Glu Glu Gly Ile Trp Ala 
945                 950             

<210>  1542
<211>  3074
<212>  DNA
<213>  Homo sapiens

<400>  1542
aattggcgta gcgcttgctg agcggcggcg gcaaccgacg tacacaaggg gcttgagcgt     60

tctgtggaga gagtgcgagg tcaggccatg aacttgggag atggtttaaa gcttgaaact    120

gaattactgg atggaaaaac caagctaata ttgtctccat atgaacataa atcaaaaatt    180

tctgtgaaga tgggaaataa ggccaagatt gcaaaatgtc ctttaagaac aaaaactggg    240

cacattctaa aatcaacaca agatacttgt attgggagtg aaaaactttt gcaaaagaag    300

ccagttggtt cagaaacatc acaggcaaaa ggtgaaaaaa atggaatgac tttttcatcc    360

actaaggatt tatgtaaaca atgtatagat aaagactgtc ttcatatcca gaaagagatt    420

tcacctgcaa cccctaatat gcagaagact agaaacaccg taaatacatc tctagtaggt    480

aaacagaagc ctcacaaaaa acacatcaca gctgaaaaca tgaagagcag tttggtgtgt    540

ctaacacaag accaactaca acagattttg atgactgtaa accaaggaaa tagatctctt    600

tccctgactg agaatggaaa ggaggcaaaa agtcaatata gtctatattt aaacagtatt    660

tctaatcagc caaaggatga gaacattatg ggattattca aaaaaactga aatggtttca    720

tctgtcccag ctgaaaataa atctgtctta aatgaacatc aggagacatc taaacagtgt    780

gagcaaaaaa ttgccataga gaatgaatgg aaaccagctg atatattcag tactctgggg    840

gaaagggaat gtgatagaag ttcgttggaa gcaaaaaaag cccagtggag gaaagagcta    900

gatgaacagg ttgctttaaa gaagaaagaa aaagaagttt ctgaaaaatg gaatgatcct    960

tggaaaaaat ctgaaagtga taaaataata tgggaaaaac atcaaattct tgaccaatct   1020

agggaaacag tactgctgga gcaccctttc agtgctgtga aacaagaact gcaaagaaaa   1080

tggattgaag agttgaataa gcaaatagaa gatgaccgtc aaagaaaaat agaggaaaaa   1140

attatatatt caaagggtga ggaacatgac agatgggcaa tgcactttga ttcattaaag   1200

agttatcctg gttctcaatc tcagctgttc tctcagtcaa cacacaaaca acctgagtac   1260

ttctgtgtct ctcctgacac tcaggagctg gctgatgtca gcagtgtttg tacacctaca   1320

accggaagcc aggttgaacc ttcagaggag gagcatatag caaaacctat taaggatgtg   1380

gttatggcaa acagtaagaa aacaaacttt ctccgttcta tgactgctct cttggaccca   1440

gctcagattg aggaacgaga cagacgacga caaaaacaat tagagcatca gaaagccatc   1500

actgcccagg tagaagagaa gcgcaggaag aaacaactgg aggaagagca aagaaagaag   1560

gaagaacaag aagaggagct tcgcttagca caggaacgtg aagagatgca gaaacagtat   1620

gaagaagaca tacttaagca aaaacaaaag gaagaaatca tgactctcaa gacaaatgag   1680

ctattccaga caatgcagcg agcacaggaa ctggcacaga gactaaaaca agaacaaaga   1740

atccgagaat tggcgcaaaa gggacatgac acttctagac tgattaaaaa tcttggtgtt   1800

gatacaatac aaatggaata taatgcatct aacatttcaa attcaagaca tgattctgat   1860

gaaatcagtg gtaaaatgaa tacatatatg aattctacga cttctaagaa ggatactggt   1920

gtgcaaacag atgacttaaa tataggaata ttcaccaatg cagaatcaca ttgtggatca   1980

ttaatggaga gggacatcac aaattgttca tctcctgaga tttcggcaga acttattgga   2040

cagtttagca ccaagaaaaa caagcaagaa ctaactcagg ataaaggagc cagcttagaa   2100

aaagaaaaca atcggtgtaa tgaccagtgt aatcagttca caagaataga gaaacaaaca   2160

aaacacatga agaaatatcc taaaaggcct gattggaata taaataagcc acctaaaagg   2220

tatattccag catcagaaaa gtaccctaaa cagcttcaaa agcagagaga agaaaaaaaa   2280

gtaaggaggc agatggaatt gcttcatttg gtagaaaaaa ataatcctgg gcacctctct   2340

caaaacagag gcatttcacc agaaattttt cattcatctc atcaagaaac ggagtcaaag   2400

ttgaggtggc atctagtcaa aaaggaagaa gagcctctga atattcattc attcagcaag   2460

gaaaggtctc catcatcacc agttccagta gtgaaaaaca gaacccaaca aactcaaaat   2520

acattacatt taccactaaa aaacagtagc tatgagagag agaatttgat ctcaggaagt   2580

aatcaaacag aattatcatc tgggatttct gaatcatccc attttattcc gtatgttcga   2640

acaaatgaga tctattacct tgatcccgat gcaccattgt ctgggccttc aacccaggac   2700

cctcagtacc aaaattcaca agactgtggc caaaaacgac agctatttga ttctgactgt   2760

gtcagggatc cacttcttaa tcctaacatg gtgaaaaata gggatcgaca gcaagcaatc   2820

cttaagggac tttcagaact gagacagggc cttctccaga agcaaaagga gttggaaagt   2880

agtctcctgc ctttagctga aaatcaagaa gagagttttg gttcttcatt ttaaatgtag   2940

aaaatcaaat ccttcacatt tgatttgtgt cttccaaatt ataaaatgtg ctcactggct   3000

caactgtatt tttcaaatag cctagattta cttatttttt taaatgctca ttaaaaactt   3060

gtatactatg tagt                                                     3074


<210>  1543
<211>  948
<212>  PRT
<213>  Homo sapiens

<400>  1543


Met Asn Leu Gly Asp Gly Leu Lys Leu Glu Thr Glu Leu Leu Asp Gly 
1               5                   10                  15      


Lys Thr Lys Leu Ile Leu Ser Pro Tyr Glu His Lys Ser Lys Ile Ser 
            20                  25                  30          


Val Lys Met Gly Asn Lys Ala Lys Ile Ala Lys Cys Pro Leu Arg Thr 
        35                  40                  45              


Lys Thr Gly His Ile Leu Lys Ser Thr Gln Asp Thr Cys Ile Gly Ser 
    50                  55                  60                  


Glu Lys Leu Leu Gln Lys Lys Pro Val Gly Ser Glu Thr Ser Gln Ala 
65                  70                  75                  80  


Lys Gly Glu Lys Asn Gly Met Thr Phe Ser Ser Thr Lys Asp Leu Cys 
                85                  90                  95      


Lys Gln Cys Ile Asp Lys Asp Cys Leu His Ile Gln Lys Glu Ile Ser 
            100                 105                 110         


Pro Ala Thr Pro Asn Met Gln Lys Thr Arg Asn Thr Val Asn Thr Ser 
        115                 120                 125             


Leu Val Gly Lys Gln Lys Pro His Lys Lys His Ile Thr Ala Glu Asn 
    130                 135                 140                 


Met Lys Ser Ser Leu Val Cys Leu Thr Gln Asp Gln Leu Gln Gln Ile 
145                 150                 155                 160 


Leu Met Thr Val Asn Gln Gly Asn Arg Ser Leu Ser Leu Thr Glu Asn 
                165                 170                 175     


Gly Lys Glu Ala Lys Ser Gln Tyr Ser Leu Tyr Leu Asn Ser Ile Ser 
            180                 185                 190         


Asn Gln Pro Lys Asp Glu Asn Ile Met Gly Leu Phe Lys Lys Thr Glu 
        195                 200                 205             


Met Val Ser Ser Val Pro Ala Glu Asn Lys Ser Val Leu Asn Glu His 
    210                 215                 220                 


Gln Glu Thr Ser Lys Gln Cys Glu Gln Lys Ile Ala Ile Glu Asn Glu 
225                 230                 235                 240 


Trp Lys Pro Ala Asp Ile Phe Ser Thr Leu Gly Glu Arg Glu Cys Asp 
                245                 250                 255     


Arg Ser Ser Leu Glu Ala Lys Lys Ala Gln Trp Arg Lys Glu Leu Asp 
            260                 265                 270         


Glu Gln Val Ala Leu Lys Lys Lys Glu Lys Glu Val Ser Glu Lys Trp 
        275                 280                 285             


Asn Asp Pro Trp Lys Lys Ser Glu Ser Asp Lys Ile Ile Trp Glu Lys 
    290                 295                 300                 


His Gln Ile Leu Asp Gln Ser Arg Glu Thr Val Leu Leu Glu His Pro 
305                 310                 315                 320 


Phe Ser Ala Val Lys Gln Glu Leu Gln Arg Lys Trp Ile Glu Glu Leu 
                325                 330                 335     


Asn Lys Gln Ile Glu Asp Asp Arg Gln Arg Lys Ile Glu Glu Lys Ile 
            340                 345                 350         


Ile Tyr Ser Lys Gly Glu Glu His Asp Arg Trp Ala Met His Phe Asp 
        355                 360                 365             


Ser Leu Lys Ser Tyr Pro Gly Ser Gln Ser Gln Leu Phe Ser Gln Ser 
    370                 375                 380                 


Thr His Lys Gln Pro Glu Tyr Phe Cys Val Ser Pro Asp Thr Gln Glu 
385                 390                 395                 400 


Leu Ala Asp Val Ser Ser Val Cys Thr Pro Thr Thr Gly Ser Gln Val 
                405                 410                 415     


Glu Pro Ser Glu Glu Glu His Ile Ala Lys Pro Ile Lys Asp Val Val 
            420                 425                 430         


Met Ala Asn Ser Lys Lys Thr Asn Phe Leu Arg Ser Met Thr Ala Leu 
        435                 440                 445             


Leu Asp Pro Ala Gln Ile Glu Glu Arg Asp Arg Arg Arg Gln Lys Gln 
    450                 455                 460                 


Leu Glu His Gln Lys Ala Ile Thr Ala Gln Val Glu Glu Lys Arg Arg 
465                 470                 475                 480 


Lys Lys Gln Leu Glu Glu Glu Gln Arg Lys Lys Glu Glu Gln Glu Glu 
                485                 490                 495     


Glu Leu Arg Leu Ala Gln Glu Arg Glu Glu Met Gln Lys Gln Tyr Glu 
            500                 505                 510         


Glu Asp Ile Leu Lys Gln Lys Gln Lys Glu Glu Ile Met Thr Leu Lys 
        515                 520                 525             


Thr Asn Glu Leu Phe Gln Thr Met Gln Arg Ala Gln Glu Leu Ala Gln 
    530                 535                 540                 


Arg Leu Lys Gln Glu Gln Arg Ile Arg Glu Leu Ala Gln Lys Gly His 
545                 550                 555                 560 


Asp Thr Ser Arg Leu Ile Lys Asn Leu Gly Val Asp Thr Ile Gln Met 
                565                 570                 575     


Glu Tyr Asn Ala Ser Asn Ile Ser Asn Ser Arg His Asp Ser Asp Glu 
            580                 585                 590         


Ile Ser Gly Lys Met Asn Thr Tyr Met Asn Ser Thr Thr Ser Lys Lys 
        595                 600                 605             


Asp Thr Gly Val Gln Thr Asp Asp Leu Asn Ile Gly Ile Phe Thr Asn 
    610                 615                 620                 


Ala Glu Ser His Cys Gly Ser Leu Met Glu Arg Asp Ile Thr Asn Cys 
625                 630                 635                 640 


Ser Ser Pro Glu Ile Ser Ala Glu Leu Ile Gly Gln Phe Ser Thr Lys 
                645                 650                 655     


Lys Asn Lys Gln Glu Leu Thr Gln Asp Lys Gly Ala Ser Leu Glu Lys 
            660                 665                 670         


Glu Asn Asn Arg Cys Asn Asp Gln Cys Asn Gln Phe Thr Arg Ile Glu 
        675                 680                 685             


Lys Gln Thr Lys His Met Lys Lys Tyr Pro Lys Arg Pro Asp Trp Asn 
    690                 695                 700                 


Ile Asn Lys Pro Pro Lys Arg Tyr Ile Pro Ala Ser Glu Lys Tyr Pro 
705                 710                 715                 720 


Lys Gln Leu Gln Lys Gln Arg Glu Glu Lys Lys Val Arg Arg Gln Met 
                725                 730                 735     


Glu Leu Leu His Leu Val Glu Lys Asn Asn Pro Gly His Leu Ser Gln 
            740                 745                 750         


Asn Arg Gly Ile Ser Pro Glu Ile Phe His Ser Ser His Gln Glu Thr 
        755                 760                 765             


Glu Ser Lys Leu Arg Trp His Leu Val Lys Lys Glu Glu Glu Pro Leu 
    770                 775                 780                 


Asn Ile His Ser Phe Ser Lys Glu Arg Ser Pro Ser Ser Pro Val Pro 
785                 790                 795                 800 


Val Val Lys Asn Arg Thr Gln Gln Thr Gln Asn Thr Leu His Leu Pro 
                805                 810                 815     


Leu Lys Asn Ser Ser Tyr Glu Arg Glu Asn Leu Ile Ser Gly Ser Asn 
            820                 825                 830         


Gln Thr Glu Leu Ser Ser Gly Ile Ser Glu Ser Ser His Phe Ile Pro 
        835                 840                 845             


Tyr Val Arg Thr Asn Glu Ile Tyr Tyr Leu Asp Pro Asp Ala Pro Leu 
    850                 855                 860                 


Ser Gly Pro Ser Thr Gln Asp Pro Gln Tyr Gln Asn Ser Gln Asp Cys 
865                 870                 875                 880 


Gly Gln Lys Arg Gln Leu Phe Asp Ser Asp Cys Val Arg Asp Pro Leu 
                885                 890                 895     


Leu Asn Pro Asn Met Val Lys Asn Arg Asp Arg Gln Gln Ala Ile Leu 
            900                 905                 910         


Lys Gly Leu Ser Glu Leu Arg Gln Gly Leu Leu Gln Lys Gln Lys Glu 
        915                 920                 925             


Leu Glu Ser Ser Leu Leu Pro Leu Ala Glu Asn Gln Glu Glu Ser Phe 
    930                 935                 940                 


Gly Ser Ser Phe 
945             

<210>  1544
<211>  3226
<212>  DNA
<213>  Homo sapiens

<400>  1544
aattggcgta gcgcttgctg agcggcggcg gcaaccgacg tacacaaggg gcttgagcgt     60

tctgtggaga gagtgcgagg tcaggccatg aacttgggag atggtttaaa gcttgaaact    120

gaattactgg atggaaaaac caagctaata ttgtctccat atgaacataa atcaaaaatt    180

tctgtgaaga tgggaaataa ggccaagatt gcaaaatgtc ctttaagaac aaaaactggg    240

cacattctaa aatcaacaca agatacttgt attgggagtg aaaaactttt gcaaaagaag    300

ccagttggtt cagaaacatc acaggcaaaa ggtgaaaaaa atggaatgac tttttcatcc    360

actaaggatt tatgtaaaca atgtatagat aaagactgtc ttcatatcca gaaagagatt    420

tcacctgcaa cccctaatat gcagaagact agaaacaccg taaatacatc tctagtaggt    480

aaacagaagc ctcacaaaaa acacatcaca gctgaaaaca tgaagagcag tttggtgtgt    540

ctaacacaag accaactaca acagattttg atgactgtaa accaaggaaa tagatctctt    600

tccctgactg agaatggaaa ggaggcaaaa agtcaatata gtctatattt aaacagtatt    660

tctaatcagc caaaggatga gaacattatg ggattattca aaaaaactga aatggtttca    720

tctgtcccag ctgaaaataa atctgtctta aatgaacatc aggagacatc taaacagtgt    780

gagcaaaaaa ttgccataga gaatgaatgg aaaccagctg atatattcag tactctgggg    840

gaaagggaat gtgatagaag ttcgttggaa gcaaaaaaag cccagtggag gaaagagcta    900

gatgaacagg ttgctttaaa gaagaaagaa aaagaagttt ctgaaaaatg gaatgatcct    960

tggaaaaaat ctgaaagtga taaaataata tgggaaaaac atcaaattct tgaccaatct   1020

aggctcttca agcattctat cacagtctcg tagccaggtt atggtggtcc aagctgatgg   1080

ggcattcaca acttagagct agtcagactt tagaggaaac agtactgctg gagcaccctt   1140

tcagtgctgt gaaacaagaa ctgcaaagaa aatggattga agagttgaat aagcaaatag   1200

aagatgaccg tcaaagaaaa atagaggaaa aaattatata ttcaaagggt gaggaacatg   1260

acagatgggc aatgcacttt gattcattaa agagttatcc tggttctcaa tctcagctgt   1320

tctctcagtc aacacacaaa caacctgagt acttctgtgt ctctcctgac actcaggagc   1380

tggctgatgt cagcagtgtt tgtacaccta caaccggaag ccaggttgaa ccttcagagg   1440

aggagcatat agcaaaacct attaaggatg tggttatggc aaacagtaag aaaacaaact   1500

ttctccgttc tatgactgct ctcttggacc cagctcagat tgaggaacga gacagacgac   1560

gacaaaaaca attagagcat cagaaagcca tcactgccca ggtagaagag aagcgcagga   1620

agaaacaact ggaggaagag caaagaaaga aggaagaaca agaagaggag cttcgcttag   1680

cacaggaacg tgaagagatg cagaaacagt atgaagaaga catacttaag caaaaacaaa   1740

aggaagaaat catgactctc aagacaaatg agctattcca gacaatgcag cgagcacagg   1800

aactggcaca gagactaaaa caagaacaaa gaatccgaga attggcgcaa aagggacatg   1860

acacttctag actgattaaa aatcttggtg ttgatacaat acaaatggaa tataatgcat   1920

ctaacatttc aaattcaaga catgattctg atgaaatcag tggtaaaatg aatacatata   1980

tgaattctac gacttctaag aaggatactg gtgtgcaaac agatgactta aatataggaa   2040

tattcaccaa tgcagaatca cattgtggat cattaatgga gagggacatc acaaattgtt   2100

catctcctga gatttcggca gaacttattg gacagtttag caccaagaaa aacaagcaag   2160

aactaactca ggataaagga gccagcttag aaaaagaaaa caatcggtgt aatgaccagt   2220

gtaatcagtt cacaagaata gagaaacaaa caaaacacat gaagaaatat cctaaaaggc   2280

ctgattggaa tataaataag ccacctaaaa ggtatattcc agcatcagaa aagtacccta   2340

aacagcttca aaagcagaga gaagaaaaaa aagtaaggag gcagatggaa ttgcttcatt   2400

tggtagaaaa aaataatcct gggcacctct ctcaaaacag aggcatttca ccagaaattt   2460

ttcattcatc tcatcaagaa acggagtcaa agttgaggtg gcatctagtc aaaaaggaag   2520

aagagcctct gaatattcat tcattcagca aggaaaggtc tccatcatca ccagttccag   2580

tagtgaaaaa cagaacccaa caaactcaaa atacattaca tttaccacta aaaaacagta   2640

gctatgagag agagaatttg atctcaggaa gtaatcaaac agaattatca tctgggattt   2700

ctgaatcatc ccattttatt ccgtatgttc gaacaaatga gatctattac cttgatcccg   2760

atgcaccatt gtctgggcct tcaacccagg accctcagta ccaaaattca caagactgtg   2820

gccaaaaacg acagctattt gattctgact gtgtcaggga tccacttctt aatcctaaca   2880

tggtgaaaaa tagggatcga cagcaagcaa tccttaaggg actttcagaa ctgagacagg   2940

gccttctcca gaagcaaaag gagttggaaa gtagtctcct gcctttagct gaaaatcaag   3000

aagagagttt tggttcttca ttttaaatgt agaaaatcaa atccttcaca tttgatttgt   3060

gtcttccaaa ttataaaatg tgctcactgg ctcaactgta tttttcaaat agcctagatt   3120

tacttatttt tttaaatgct cattaaaaac ttgtatacta tgtagtaaaa tgctgtactt   3180

gttctataca ataaaacaga tacttctttt gtaaaagctt agtagt                  3226


<210>  1545
<211>  649
<212>  PRT
<213>  Homo sapiens

<400>  1545


Met Gly His Ser Gln Leu Arg Ala Ser Gln Thr Leu Glu Glu Thr Val 
1               5                   10                  15      


Leu Leu Glu His Pro Phe Ser Ala Val Lys Gln Glu Leu Gln Arg Lys 
            20                  25                  30          


Trp Ile Glu Glu Leu Asn Lys Gln Ile Glu Asp Asp Arg Gln Arg Lys 
        35                  40                  45              


Ile Glu Glu Lys Ile Ile Tyr Ser Lys Gly Glu Glu His Asp Arg Trp 
    50                  55                  60                  


Ala Met His Phe Asp Ser Leu Lys Ser Tyr Pro Gly Ser Gln Ser Gln 
65                  70                  75                  80  


Leu Phe Ser Gln Ser Thr His Lys Gln Pro Glu Tyr Phe Cys Val Ser 
                85                  90                  95      


Pro Asp Thr Gln Glu Leu Ala Asp Val Ser Ser Val Cys Thr Pro Thr 
            100                 105                 110         


Thr Gly Ser Gln Val Glu Pro Ser Glu Glu Glu His Ile Ala Lys Pro 
        115                 120                 125             


Ile Lys Asp Val Val Met Ala Asn Ser Lys Lys Thr Asn Phe Leu Arg 
    130                 135                 140                 


Ser Met Thr Ala Leu Leu Asp Pro Ala Gln Ile Glu Glu Arg Asp Arg 
145                 150                 155                 160 


Arg Arg Gln Lys Gln Leu Glu His Gln Lys Ala Ile Thr Ala Gln Val 
                165                 170                 175     


Glu Glu Lys Arg Arg Lys Lys Gln Leu Glu Glu Glu Gln Arg Lys Lys 
            180                 185                 190         


Glu Glu Gln Glu Glu Glu Leu Arg Leu Ala Gln Glu Arg Glu Glu Met 
        195                 200                 205             


Gln Lys Gln Tyr Glu Glu Asp Ile Leu Lys Gln Lys Gln Lys Glu Glu 
    210                 215                 220                 


Ile Met Thr Leu Lys Thr Asn Glu Leu Phe Gln Thr Met Gln Arg Ala 
225                 230                 235                 240 


Gln Glu Leu Ala Gln Arg Leu Lys Gln Glu Gln Arg Ile Arg Glu Leu 
                245                 250                 255     


Ala Gln Lys Gly His Asp Thr Ser Arg Leu Ile Lys Asn Leu Gly Val 
            260                 265                 270         


Asp Thr Ile Gln Met Glu Tyr Asn Ala Ser Asn Ile Ser Asn Ser Arg 
        275                 280                 285             


His Asp Ser Asp Glu Ile Ser Gly Lys Met Asn Thr Tyr Met Asn Ser 
    290                 295                 300                 


Thr Thr Ser Lys Lys Asp Thr Gly Val Gln Thr Asp Asp Leu Asn Ile 
305                 310                 315                 320 


Gly Ile Phe Thr Asn Ala Glu Ser His Cys Gly Ser Leu Met Glu Arg 
                325                 330                 335     


Asp Ile Thr Asn Cys Ser Ser Pro Glu Ile Ser Ala Glu Leu Ile Gly 
            340                 345                 350         


Gln Phe Ser Thr Lys Lys Asn Lys Gln Glu Leu Thr Gln Asp Lys Gly 
        355                 360                 365             


Ala Ser Leu Glu Lys Glu Asn Asn Arg Cys Asn Asp Gln Cys Asn Gln 
    370                 375                 380                 


Phe Thr Arg Ile Glu Lys Gln Thr Lys His Met Lys Lys Tyr Pro Lys 
385                 390                 395                 400 


Arg Pro Asp Trp Asn Ile Asn Lys Pro Pro Lys Arg Tyr Ile Pro Ala 
                405                 410                 415     


Ser Glu Lys Tyr Pro Lys Gln Leu Gln Lys Gln Arg Glu Glu Lys Lys 
            420                 425                 430         


Val Arg Arg Gln Met Glu Leu Leu His Leu Val Glu Lys Asn Asn Pro 
        435                 440                 445             


Gly His Leu Ser Gln Asn Arg Gly Ile Ser Pro Glu Ile Phe His Ser 
    450                 455                 460                 


Ser His Gln Glu Thr Glu Ser Lys Leu Arg Trp His Leu Val Lys Lys 
465                 470                 475                 480 


Glu Glu Glu Pro Leu Asn Ile His Ser Phe Ser Lys Glu Arg Ser Pro 
                485                 490                 495     


Ser Ser Pro Val Pro Val Val Lys Asn Arg Thr Gln Gln Thr Gln Asn 
            500                 505                 510         


Thr Leu His Leu Pro Leu Lys Asn Ser Ser Tyr Glu Arg Glu Asn Leu 
        515                 520                 525             


Ile Ser Gly Ser Asn Gln Thr Glu Leu Ser Ser Gly Ile Ser Glu Ser 
    530                 535                 540                 


Ser His Phe Ile Pro Tyr Val Arg Thr Asn Glu Ile Tyr Tyr Leu Asp 
545                 550                 555                 560 


Pro Asp Ala Pro Leu Ser Gly Pro Ser Thr Gln Asp Pro Gln Tyr Gln 
                565                 570                 575     


Asn Ser Gln Asp Cys Gly Gln Lys Arg Gln Leu Phe Asp Ser Asp Cys 
            580                 585                 590         


Val Arg Asp Pro Leu Leu Asn Pro Asn Met Val Lys Asn Arg Asp Arg 
        595                 600                 605             


Gln Gln Ala Ile Leu Lys Gly Leu Ser Glu Leu Arg Gln Gly Leu Leu 
    610                 615                 620                 


Gln Lys Gln Lys Glu Leu Glu Ser Ser Leu Leu Pro Leu Ala Glu Asn 
625                 630                 635                 640 


Gln Glu Glu Ser Phe Gly Ser Ser Phe 
                645                 

<210>  1546
<211>  3134
<212>  DNA
<213>  Homo sapiens

<400>  1546
aattggcgta gcgcttgctg agcggcggcg gcaaccgacg tacacaaggg gcttgagcgt     60

tctgtggaga gagtgcgagg tcaggccatg aacttgggag atggtttaaa gcttgaaact    120

gaattactgg atggaaaaac caagctaata ttgtctccat atgaacataa atcaaaaatt    180

tctgtgaaga tgggaaataa ggccaagatt gcaaaatgtc ctttaagaac aaaaactggg    240

cacattctaa aatcaacaca agatacttgt attgggagtg aaaaactttt gcaaaagaag    300

ccagttggtt cagaaacatc acaggcaaaa ggtgaaaaaa atggaatgac tttttcatcc    360

actaaggatt tatgtaaaca atgtatagat aaagactgtc ttcatatcca gaaagagatt    420

tcacctgcaa cccctaatat gcagaagact agaaacaccg taaatacatc tctagtaggt    480

aaacagaagc ctcacaaaaa acacatcaca gctgaaaaca tgaagagcag tttggtgtgt    540

ctaacacaag accaactaca acagattttg atgactgtaa accaaggaaa tagatctctt    600

tccctgactg agaatggaaa ggaggcaaaa agtcaatata gtctatattt aaacagtatt    660

tctaatcagc caaaggatga gaacattatg ggattattca aaaaaactga aatggtttca    720

tctgtcccag ctgaaaataa atctgtctta aatgaacatc aggagacatc taaacagtgt    780

gagcaaaaaa ttgccataga gaatgaatgg aaaccagctg atatattcag tactctgggg    840

gaaagggaat gtgatagaag ttcgttggaa gcaaaaaaag cccagtggag gaaagagcta    900

gatgaacagg ttgctttaaa gaagaaagaa aaagaagttt ctgaaaaatg gaatgatcct    960

tggaaaaaat ctgaaagtga taaaataata tgggaaaaac atcaaattct tgaccaatct   1020

agggaaacag tactgctgga gcaccctttc agtgctgtga aacaagaact gcaaagaaaa   1080

tggattgaag agttgaataa gcaaatagaa gatgaccgtc aaagaaaaat agaggaaaaa   1140

attatatatt caaagggtga ggaacatgac agatgggcaa tgcactttga ttcattaaag   1200

agttatcctg gttctcaatc tcagctgttc tctcagtcaa cacacaaaca acctgagtac   1260

ttctgtgtct ctcctgacac tcaggagctg gctgatgtca gcagtgtttg tacacctaca   1320

accggaagcc aggttgaacc ttcagaggag gagcatatag caaaacctat taaggatgtg   1380

gttatggcaa acagtaagaa aacaaacttt ctccgttcta tgactgctct cttggaccca   1440

gctcagattg aggaacgaga cagacgacga caaaaacaat tagagcatca gaaagccatc   1500

actgcccagg tagaagagaa gcgcaggaag aaacaactgg aggaagagca aagaaagaag   1560

gaagaacaag aagaggagct tcgcttagca caggaacgtg aagagatgca gaaacagtat   1620

gaagaagaca tacttaagca aaaacaaaag gaagaaatca tgactctcaa gacaaatgag   1680

ctattccaga caatgcagcg agcacaggaa ctggcacaga gactaaaaca agaacaaaga   1740

atccgagaat tggcgcaaaa gggacatgac acttctagac tgattaaaaa tcttggtgtt   1800

gatacaatac aaatggaata taatgcatct aacatttcaa attcaagaca tgattctgat   1860

gaaatcagtg gtaaaatgaa tacatatatg aattctacga cttctaagaa ggatactggt   1920

gtgcaaacag atgacttaaa tataggaata ttcaccaatg cagaatcaca ttgtggatca   1980

ttaatggaga gggacatcac aaattgttca tctcctgaga tttcggcaga acttattgga   2040

cagtttagca ccaagaaaaa caagcaagaa ctaactcagg ataaaggagc cagcttagaa   2100

aaagaaaaca atcggtgtaa tgaccagtgt aatcagttca caagaataga gaaacaaaca   2160

aaacacatga agaaatatcc taaaaggcct gattggaata taaataagcc acctaaaagg   2220

tatattccag catcagaaaa gtaccctaaa cagcttcaaa agcagagaga agaaaaaaaa   2280

gtaaggaggc agatggaatt gcttcatttg gtagaaaaaa ataatcctgg gcacctctct   2340

caaaacagag gcatttcacc agaaattttt cattcatctc atcaagaaac ggagtcaaag   2400

ttgaggtggc atctagtcaa aaaggaagaa gagcctctga atattcattc attcagcaag   2460

gaaaggtctc catcatcacc agttccagta gtgaaaaaca gaacccaaca aactcaaaat   2520

acattacatt taccactaaa aaacagtagc tatgagagag agaatttgat ctcaggaagt   2580

aatcaaacag aattatcatc tgggatttct gaatcatccc attttattcc gtatgttcga   2640

acaaatgaga tctattacct tgatcccgat gcaccattgt ctgggccttc aacccaggac   2700

cctcagtacc aaaattcaca agactgtggc caaaaacgac agctatttga ttctgactgt   2760

gtcagggatc cacttcttaa tcctaacatg gtgaaaaata gggatcgaca gcaagcaatc   2820

cttaagggac tttcagaact gagacagggc cttctccaga agcaaaagga gttggaaagt   2880

agtctcctgc ctttagctga aaatcaagaa gagagttttg gttcttcatt ttaaatgtag   2940

aaaatcaaat ccttcacatt tgatttgtgt cttccaaatt ataaaatgtg ctcactggct   3000

caactgtatt tttcaaatag cctagattta cttatttttt taaatgctca ttaaaaactt   3060

gtatactatg tagtaaaatg ctgtacttgt tctatacaat aaaacagata cttcttttgt   3120

aaaagcttag tagt                                                     3134


<210>  1547
<211>  948
<212>  PRT
<213>  Homo sapiens

<400>  1547


Met Asn Leu Gly Asp Gly Leu Lys Leu Glu Thr Glu Leu Leu Asp Gly 
1               5                   10                  15      


Lys Thr Lys Leu Ile Leu Ser Pro Tyr Glu His Lys Ser Lys Ile Ser 
            20                  25                  30          


Val Lys Met Gly Asn Lys Ala Lys Ile Ala Lys Cys Pro Leu Arg Thr 
        35                  40                  45              


Lys Thr Gly His Ile Leu Lys Ser Thr Gln Asp Thr Cys Ile Gly Ser 
    50                  55                  60                  


Glu Lys Leu Leu Gln Lys Lys Pro Val Gly Ser Glu Thr Ser Gln Ala 
65                  70                  75                  80  


Lys Gly Glu Lys Asn Gly Met Thr Phe Ser Ser Thr Lys Asp Leu Cys 
                85                  90                  95      


Lys Gln Cys Ile Asp Lys Asp Cys Leu His Ile Gln Lys Glu Ile Ser 
            100                 105                 110         


Pro Ala Thr Pro Asn Met Gln Lys Thr Arg Asn Thr Val Asn Thr Ser 
        115                 120                 125             


Leu Val Gly Lys Gln Lys Pro His Lys Lys His Ile Thr Ala Glu Asn 
    130                 135                 140                 


Met Lys Ser Ser Leu Val Cys Leu Thr Gln Asp Gln Leu Gln Gln Ile 
145                 150                 155                 160 


Leu Met Thr Val Asn Gln Gly Asn Arg Ser Leu Ser Leu Thr Glu Asn 
                165                 170                 175     


Gly Lys Glu Ala Lys Ser Gln Tyr Ser Leu Tyr Leu Asn Ser Ile Ser 
            180                 185                 190         


Asn Gln Pro Lys Asp Glu Asn Ile Met Gly Leu Phe Lys Lys Thr Glu 
        195                 200                 205             


Met Val Ser Ser Val Pro Ala Glu Asn Lys Ser Val Leu Asn Glu His 
    210                 215                 220                 


Gln Glu Thr Ser Lys Gln Cys Glu Gln Lys Ile Ala Ile Glu Asn Glu 
225                 230                 235                 240 


Trp Lys Pro Ala Asp Ile Phe Ser Thr Leu Gly Glu Arg Glu Cys Asp 
                245                 250                 255     


Arg Ser Ser Leu Glu Ala Lys Lys Ala Gln Trp Arg Lys Glu Leu Asp 
            260                 265                 270         


Glu Gln Val Ala Leu Lys Lys Lys Glu Lys Glu Val Ser Glu Lys Trp 
        275                 280                 285             


Asn Asp Pro Trp Lys Lys Ser Glu Ser Asp Lys Ile Ile Trp Glu Lys 
    290                 295                 300                 


His Gln Ile Leu Asp Gln Ser Arg Glu Thr Val Leu Leu Glu His Pro 
305                 310                 315                 320 


Phe Ser Ala Val Lys Gln Glu Leu Gln Arg Lys Trp Ile Glu Glu Leu 
                325                 330                 335     


Asn Lys Gln Ile Glu Asp Asp Arg Gln Arg Lys Ile Glu Glu Lys Ile 
            340                 345                 350         


Ile Tyr Ser Lys Gly Glu Glu His Asp Arg Trp Ala Met His Phe Asp 
        355                 360                 365             


Ser Leu Lys Ser Tyr Pro Gly Ser Gln Ser Gln Leu Phe Ser Gln Ser 
    370                 375                 380                 


Thr His Lys Gln Pro Glu Tyr Phe Cys Val Ser Pro Asp Thr Gln Glu 
385                 390                 395                 400 


Leu Ala Asp Val Ser Ser Val Cys Thr Pro Thr Thr Gly Ser Gln Val 
                405                 410                 415     


Glu Pro Ser Glu Glu Glu His Ile Ala Lys Pro Ile Lys Asp Val Val 
            420                 425                 430         


Met Ala Asn Ser Lys Lys Thr Asn Phe Leu Arg Ser Met Thr Ala Leu 
        435                 440                 445             


Leu Asp Pro Ala Gln Ile Glu Glu Arg Asp Arg Arg Arg Gln Lys Gln 
    450                 455                 460                 


Leu Glu His Gln Lys Ala Ile Thr Ala Gln Val Glu Glu Lys Arg Arg 
465                 470                 475                 480 


Lys Lys Gln Leu Glu Glu Glu Gln Arg Lys Lys Glu Glu Gln Glu Glu 
                485                 490                 495     


Glu Leu Arg Leu Ala Gln Glu Arg Glu Glu Met Gln Lys Gln Tyr Glu 
            500                 505                 510         


Glu Asp Ile Leu Lys Gln Lys Gln Lys Glu Glu Ile Met Thr Leu Lys 
        515                 520                 525             


Thr Asn Glu Leu Phe Gln Thr Met Gln Arg Ala Gln Glu Leu Ala Gln 
    530                 535                 540                 


Arg Leu Lys Gln Glu Gln Arg Ile Arg Glu Leu Ala Gln Lys Gly His 
545                 550                 555                 560 


Asp Thr Ser Arg Leu Ile Lys Asn Leu Gly Val Asp Thr Ile Gln Met 
                565                 570                 575     


Glu Tyr Asn Ala Ser Asn Ile Ser Asn Ser Arg His Asp Ser Asp Glu 
            580                 585                 590         


Ile Ser Gly Lys Met Asn Thr Tyr Met Asn Ser Thr Thr Ser Lys Lys 
        595                 600                 605             


Asp Thr Gly Val Gln Thr Asp Asp Leu Asn Ile Gly Ile Phe Thr Asn 
    610                 615                 620                 


Ala Glu Ser His Cys Gly Ser Leu Met Glu Arg Asp Ile Thr Asn Cys 
625                 630                 635                 640 


Ser Ser Pro Glu Ile Ser Ala Glu Leu Ile Gly Gln Phe Ser Thr Lys 
                645                 650                 655     


Lys Asn Lys Gln Glu Leu Thr Gln Asp Lys Gly Ala Ser Leu Glu Lys 
            660                 665                 670         


Glu Asn Asn Arg Cys Asn Asp Gln Cys Asn Gln Phe Thr Arg Ile Glu 
        675                 680                 685             


Lys Gln Thr Lys His Met Lys Lys Tyr Pro Lys Arg Pro Asp Trp Asn 
    690                 695                 700                 


Ile Asn Lys Pro Pro Lys Arg Tyr Ile Pro Ala Ser Glu Lys Tyr Pro 
705                 710                 715                 720 


Lys Gln Leu Gln Lys Gln Arg Glu Glu Lys Lys Val Arg Arg Gln Met 
                725                 730                 735     


Glu Leu Leu His Leu Val Glu Lys Asn Asn Pro Gly His Leu Ser Gln 
            740                 745                 750         


Asn Arg Gly Ile Ser Pro Glu Ile Phe His Ser Ser His Gln Glu Thr 
        755                 760                 765             


Glu Ser Lys Leu Arg Trp His Leu Val Lys Lys Glu Glu Glu Pro Leu 
    770                 775                 780                 


Asn Ile His Ser Phe Ser Lys Glu Arg Ser Pro Ser Ser Pro Val Pro 
785                 790                 795                 800 


Val Val Lys Asn Arg Thr Gln Gln Thr Gln Asn Thr Leu His Leu Pro 
                805                 810                 815     


Leu Lys Asn Ser Ser Tyr Glu Arg Glu Asn Leu Ile Ser Gly Ser Asn 
            820                 825                 830         


Gln Thr Glu Leu Ser Ser Gly Ile Ser Glu Ser Ser His Phe Ile Pro 
        835                 840                 845             


Tyr Val Arg Thr Asn Glu Ile Tyr Tyr Leu Asp Pro Asp Ala Pro Leu 
    850                 855                 860                 


Ser Gly Pro Ser Thr Gln Asp Pro Gln Tyr Gln Asn Ser Gln Asp Cys 
865                 870                 875                 880 


Gly Gln Lys Arg Gln Leu Phe Asp Ser Asp Cys Val Arg Asp Pro Leu 
                885                 890                 895     


Leu Asn Pro Asn Met Val Lys Asn Arg Asp Arg Gln Gln Ala Ile Leu 
            900                 905                 910         


Lys Gly Leu Ser Glu Leu Arg Gln Gly Leu Leu Gln Lys Gln Lys Glu 
        915                 920                 925             


Leu Glu Ser Ser Leu Leu Pro Leu Ala Glu Asn Gln Glu Glu Ser Phe 
    930                 935                 940                 


Gly Ser Ser Phe 
945             

<210>  1548
<211>  4065
<212>  DNA
<213>  Homo sapiens

<400>  1548
aattggcgta gcgcttgctg agcggcggcg gcaaccgacg tacacaaggg gcttgagcgt     60

tctgtggaga gagtgcgagg tcaggccatg aacttgggag atggtttaaa gcttgaaact    120

gaattactgg atggaaaaac caagctaata ttgtctccat atgaacataa atcaaaaatt    180

tctgtgaaga tgggaaataa ggccaagatt gcaaaatgtc ctttaagaac aaaaactggg    240

cacattctaa aatcaacaca agatacttgt attgggagtg aaaaactttt gcaaaagaag    300

ccagttggtt cagaaacatc acaggcaaaa ggtgaaaaaa atggaatgac tttttcatcc    360

actaaggatt tatgtaaaca atgtatagat aaagactgtc ttcatatcca gaaagagatt    420

tcacctgcaa cccctaatat gcagaagact agaaacaccg taaatacatc tctagtaggt    480

aaacagaagc ctcacaaaaa acacatcaca gctgaaaaca tgaagagcag tttggtgtgt    540

ctaacacaag accaactaca acagattttg atgactgtaa accaaggaaa tagatctctt    600

tccctgactg agaatggaaa ggaggcaaaa agtcaatata gtctatattt aaacagtatt    660

tctaatcagc caaaggatga gaacattatg ggattattca aaaaaactga aatggtttca    720

tctgtcccag ctgaaaataa atctgtctta aatgaacatc aggagacatc taaacagtgt    780

gagcaaaaaa ttgccataga gaatgaatgg aaaccagctg atatattcag tactctgggg    840

gaaagggaat gtgatagaag ttcgttggaa gcaaaaaaag cccagtggag gaaagagcta    900

gatgaacagg ttgctttaaa gaagaaagaa aaagaagttt ctgaaaaatg gaatgatcct    960

tggaaaaaat ctgaaagtga taaaataata tgggaaaaac atcaaattct tgaccaatct   1020

agggaaacag tactgctgga gcaccctttc agtgctgtga aacaagaact gcaaagaaaa   1080

tggattgaag agttgaataa gcaaatagaa gatgaccgtc aaagaaaaat agaggaaaaa   1140

attatatatt caaagggtga ggaacatgac agatgggcaa tgcactttga ttcattaaag   1200

agttatcctg gttctcaatc tcagctgttc tctcagtcaa cacacaaaca acctgagtac   1260

ttctgtgtct ctcctgacac tcaggagctg gctgatgtca gcagtgtttg tacacctaca   1320

accggaagcc aggttgaacc ttcagaggag gagcatatag caaaacctat taaggatgtg   1380

gttatggcaa acagtaagaa aacaaacttt ctccgttcta tgactgctct cttggaccca   1440

gctcagattg aggaacgaga cagacgacga caaaaacaat tagagcatca gaaagccatc   1500

actgcccagg tagaagagaa gcgcaggaag aaacaactgg aggaagagca aagaaagaag   1560

gaagaacaag aagaggagct tcgcttagca caggaacgtg aagagatgca gaaacagtat   1620

gaagaagaca tacttaagca aaaacaaaag gaagaaatca tgactctcaa gacaaatgag   1680

ctattccaga caatgcagcg agcacaggaa ctggcacaga gactaaaaca agaacaaaga   1740

atccgagaat tggcgcaaaa gggacatgac acttctagac tgattaaaaa tcttggtgtt   1800

gatacaatac aaatggaata taatgcatct aacatttcaa attcaagaca tgattctgat   1860

gaaatcagtg gtaaaatgaa tacatatatg aattctacga cttctaagaa ggatactggt   1920

gtgcaaacag atgacttaaa tataggaata ttcaccaatg cagaatcaca ttgtggatca   1980

ttaatggaga gggacatcac aaattgttca tctcctgaga tttcggcaga acttattgga   2040

cagtttagca ccaagaaaaa caagcaagaa ctaactcagg ataaaggagc cagcttagaa   2100

aaagaaaaca atcggtgtaa tgaccagtgt aatcagttca caagaataga gaaacaaaca   2160

aaacacatga agaaatatcc taaaaggcct gattggaata taaataagcc acctaaaagg   2220

tatattccag catcagaaaa gtaccctaaa cagcttcaaa agcagagaga agaaaaaaaa   2280

gtaaggaggc agatggaatt gcttcatttg gtagaaaaaa ataatcctgg gcacctctct   2340

caaaacagag gcatttcacc agaaattttt cattcatctc atcaagaaac ggagtcaaag   2400

ttgaggtggc atctagtcaa aaaggaagaa gagcctctga atattcattc attcagcaag   2460

gaaaggtctc catcatcacc agttccagta gtgaaaaaca gaacccaaca aactcaaaat   2520

acattacatt taccactaaa aaacagtagc tatgagagag agaatttgat ctcaggaagt   2580

aatcaaacag aattatcatc tgggatttct gaatcatccc attttattcc gtatgttcga   2640

acaaatgaga tctattacct tgatcccgat gcaccattgt ctgggccttc aacccaggac   2700

cctcagtacc aaaattcaca agactgtggc caaaaacgac agctatttga ttctgactgt   2760

gtcagggatc cacttcttaa tcctaacatg gtgaaaaata gggatcgaca gcaagcaatc   2820

cttaagggac tttcagaact gagacagggc cttctccaga agcaaaagga gttggaaagt   2880

agtctcctgc ctttagctga aaatcaagaa gagagttttg gttcttcatt ttaaatgtag   2940

aaaatcaaat ccttcacatt tgatttgtgt cttccaaatt ataaaatgtg ctcactggct   3000

caactgtatt tttcaaatag cctagattta cttatttttt taaatgctca ttaaaaactt   3060

gtatactatg tagtaaaatg ctgtacttgt tctatacaat aaaacagata cttcttttgt   3120

aaaagcttag tagtaaaaaa aaaaaaaaaa aaaccggttc ttctgctctg tcaccacctg   3180

ggtattgaag ccctataaaa acactttcta cttaccttaa tatagtctgg cgttgctggg   3240

acctcacagt gttctttcac actttttatg taacttagga actgaaatac cactcatgca   3300

tttgttctaa agtgccaaag ttctgtctaa cttattaaca cgtctagacc cataactcca   3360

taacttttac tgaaataaca caaattcagt ttaggctcct tctctaaatc ctgacattta   3420

tttgcactat gacatttatt tgtagaaatt gcaattttca aaaacatttt taaaagttag   3480

cattagtaac aagttagtaa ttagtattag aggcagtagt taggaataga tacgggtttg   3540

aaagctatct ccactgtatc tgtctagtat agcattaatg tgttcaacaa atggtaatta   3600

ctactaagac cacctcaaaa atatattccc attatacttc cattttgcta aaactaattt   3660

aaaaatcaaa ttgttcaacg cctttgataa acagaagcct atcttttgaa ataaaaaatt   3720

taatttcatt aaatcaagga ttgcgcaggt actgaaaatt atccaatact ctcaaaaagt   3780

taccagaatt ttagcaatag gcagttttta catgactaag cctagagata aaaaatgtgt   3840

cctatgtaca tagtttatta tctaaatgaa actgcactgt tagataaatc ttgaggtatc   3900

gagccaaaat cctgtaaata ttaacactgc tattactgac ttatacctgt gtaaacacag   3960

tatacaaaag cctacatcaa aataattcac ttcaacaaaa gtactttata tcaggtgaca   4020

ttagagaaaa agaagtaaag cctttgctgt ttaccgtcct cctgc                   4065


<210>  1549
<211>  948
<212>  PRT
<213>  Homo sapiens

<400>  1549


Met Asn Leu Gly Asp Gly Leu Lys Leu Glu Thr Glu Leu Leu Asp Gly 
1               5                   10                  15      


Lys Thr Lys Leu Ile Leu Ser Pro Tyr Glu His Lys Ser Lys Ile Ser 
            20                  25                  30          


Val Lys Met Gly Asn Lys Ala Lys Ile Ala Lys Cys Pro Leu Arg Thr 
        35                  40                  45              


Lys Thr Gly His Ile Leu Lys Ser Thr Gln Asp Thr Cys Ile Gly Ser 
    50                  55                  60                  


Glu Lys Leu Leu Gln Lys Lys Pro Val Gly Ser Glu Thr Ser Gln Ala 
65                  70                  75                  80  


Lys Gly Glu Lys Asn Gly Met Thr Phe Ser Ser Thr Lys Asp Leu Cys 
                85                  90                  95      


Lys Gln Cys Ile Asp Lys Asp Cys Leu His Ile Gln Lys Glu Ile Ser 
            100                 105                 110         


Pro Ala Thr Pro Asn Met Gln Lys Thr Arg Asn Thr Val Asn Thr Ser 
        115                 120                 125             


Leu Val Gly Lys Gln Lys Pro His Lys Lys His Ile Thr Ala Glu Asn 
    130                 135                 140                 


Met Lys Ser Ser Leu Val Cys Leu Thr Gln Asp Gln Leu Gln Gln Ile 
145                 150                 155                 160 


Leu Met Thr Val Asn Gln Gly Asn Arg Ser Leu Ser Leu Thr Glu Asn 
                165                 170                 175     


Gly Lys Glu Ala Lys Ser Gln Tyr Ser Leu Tyr Leu Asn Ser Ile Ser 
            180                 185                 190         


Asn Gln Pro Lys Asp Glu Asn Ile Met Gly Leu Phe Lys Lys Thr Glu 
        195                 200                 205             


Met Val Ser Ser Val Pro Ala Glu Asn Lys Ser Val Leu Asn Glu His 
    210                 215                 220                 


Gln Glu Thr Ser Lys Gln Cys Glu Gln Lys Ile Ala Ile Glu Asn Glu 
225                 230                 235                 240 


Trp Lys Pro Ala Asp Ile Phe Ser Thr Leu Gly Glu Arg Glu Cys Asp 
                245                 250                 255     


Arg Ser Ser Leu Glu Ala Lys Lys Ala Gln Trp Arg Lys Glu Leu Asp 
            260                 265                 270         


Glu Gln Val Ala Leu Lys Lys Lys Glu Lys Glu Val Ser Glu Lys Trp 
        275                 280                 285             


Asn Asp Pro Trp Lys Lys Ser Glu Ser Asp Lys Ile Ile Trp Glu Lys 
    290                 295                 300                 


His Gln Ile Leu Asp Gln Ser Arg Glu Thr Val Leu Leu Glu His Pro 
305                 310                 315                 320 


Phe Ser Ala Val Lys Gln Glu Leu Gln Arg Lys Trp Ile Glu Glu Leu 
                325                 330                 335     


Asn Lys Gln Ile Glu Asp Asp Arg Gln Arg Lys Ile Glu Glu Lys Ile 
            340                 345                 350         


Ile Tyr Ser Lys Gly Glu Glu His Asp Arg Trp Ala Met His Phe Asp 
        355                 360                 365             


Ser Leu Lys Ser Tyr Pro Gly Ser Gln Ser Gln Leu Phe Ser Gln Ser 
    370                 375                 380                 


Thr His Lys Gln Pro Glu Tyr Phe Cys Val Ser Pro Asp Thr Gln Glu 
385                 390                 395                 400 


Leu Ala Asp Val Ser Ser Val Cys Thr Pro Thr Thr Gly Ser Gln Val 
                405                 410                 415     


Glu Pro Ser Glu Glu Glu His Ile Ala Lys Pro Ile Lys Asp Val Val 
            420                 425                 430         


Met Ala Asn Ser Lys Lys Thr Asn Phe Leu Arg Ser Met Thr Ala Leu 
        435                 440                 445             


Leu Asp Pro Ala Gln Ile Glu Glu Arg Asp Arg Arg Arg Gln Lys Gln 
    450                 455                 460                 


Leu Glu His Gln Lys Ala Ile Thr Ala Gln Val Glu Glu Lys Arg Arg 
465                 470                 475                 480 


Lys Lys Gln Leu Glu Glu Glu Gln Arg Lys Lys Glu Glu Gln Glu Glu 
                485                 490                 495     


Glu Leu Arg Leu Ala Gln Glu Arg Glu Glu Met Gln Lys Gln Tyr Glu 
            500                 505                 510         


Glu Asp Ile Leu Lys Gln Lys Gln Lys Glu Glu Ile Met Thr Leu Lys 
        515                 520                 525             


Thr Asn Glu Leu Phe Gln Thr Met Gln Arg Ala Gln Glu Leu Ala Gln 
    530                 535                 540                 


Arg Leu Lys Gln Glu Gln Arg Ile Arg Glu Leu Ala Gln Lys Gly His 
545                 550                 555                 560 


Asp Thr Ser Arg Leu Ile Lys Asn Leu Gly Val Asp Thr Ile Gln Met 
                565                 570                 575     


Glu Tyr Asn Ala Ser Asn Ile Ser Asn Ser Arg His Asp Ser Asp Glu 
            580                 585                 590         


Ile Ser Gly Lys Met Asn Thr Tyr Met Asn Ser Thr Thr Ser Lys Lys 
        595                 600                 605             


Asp Thr Gly Val Gln Thr Asp Asp Leu Asn Ile Gly Ile Phe Thr Asn 
    610                 615                 620                 


Ala Glu Ser His Cys Gly Ser Leu Met Glu Arg Asp Ile Thr Asn Cys 
625                 630                 635                 640 


Ser Ser Pro Glu Ile Ser Ala Glu Leu Ile Gly Gln Phe Ser Thr Lys 
                645                 650                 655     


Lys Asn Lys Gln Glu Leu Thr Gln Asp Lys Gly Ala Ser Leu Glu Lys 
            660                 665                 670         


Glu Asn Asn Arg Cys Asn Asp Gln Cys Asn Gln Phe Thr Arg Ile Glu 
        675                 680                 685             


Lys Gln Thr Lys His Met Lys Lys Tyr Pro Lys Arg Pro Asp Trp Asn 
    690                 695                 700                 


Ile Asn Lys Pro Pro Lys Arg Tyr Ile Pro Ala Ser Glu Lys Tyr Pro 
705                 710                 715                 720 


Lys Gln Leu Gln Lys Gln Arg Glu Glu Lys Lys Val Arg Arg Gln Met 
                725                 730                 735     


Glu Leu Leu His Leu Val Glu Lys Asn Asn Pro Gly His Leu Ser Gln 
            740                 745                 750         


Asn Arg Gly Ile Ser Pro Glu Ile Phe His Ser Ser His Gln Glu Thr 
        755                 760                 765             


Glu Ser Lys Leu Arg Trp His Leu Val Lys Lys Glu Glu Glu Pro Leu 
    770                 775                 780                 


Asn Ile His Ser Phe Ser Lys Glu Arg Ser Pro Ser Ser Pro Val Pro 
785                 790                 795                 800 


Val Val Lys Asn Arg Thr Gln Gln Thr Gln Asn Thr Leu His Leu Pro 
                805                 810                 815     


Leu Lys Asn Ser Ser Tyr Glu Arg Glu Asn Leu Ile Ser Gly Ser Asn 
            820                 825                 830         


Gln Thr Glu Leu Ser Ser Gly Ile Ser Glu Ser Ser His Phe Ile Pro 
        835                 840                 845             


Tyr Val Arg Thr Asn Glu Ile Tyr Tyr Leu Asp Pro Asp Ala Pro Leu 
    850                 855                 860                 


Ser Gly Pro Ser Thr Gln Asp Pro Gln Tyr Gln Asn Ser Gln Asp Cys 
865                 870                 875                 880 


Gly Gln Lys Arg Gln Leu Phe Asp Ser Asp Cys Val Arg Asp Pro Leu 
                885                 890                 895     


Leu Asn Pro Asn Met Val Lys Asn Arg Asp Arg Gln Gln Ala Ile Leu 
            900                 905                 910         


Lys Gly Leu Ser Glu Leu Arg Gln Gly Leu Leu Gln Lys Gln Lys Glu 
        915                 920                 925             


Leu Glu Ser Ser Leu Leu Pro Leu Ala Glu Asn Gln Glu Glu Ser Phe 
    930                 935                 940                 


Gly Ser Ser Phe 
945             

<210>  1550
<211>  1009
<212>  DNA
<213>  Homo sapiens

<400>  1550
gtagcgcttg ctgagcggcg gcggcaaccg acgtacacaa ggggcttgag cgttctgtgg     60

agagagtgcg aggtcaggcc atgaacttgg gagatggttt aaagcttgaa actgaattac    120

tggatggaaa aaccaagcta atattgtctc catatgaaca taaatcaaaa atttctgtga    180

agtgtcttaa agtctttgct tgtctgtgga tagaacccag tttggatgat gtaccacttt    240

atccttcaac tctaagccct tgatggcttt acttgcaggt ttaattaagg tgaagaagtt    300

gctggagtac ccgaaatatc actcaataaa tagatgggaa ataaggccaa gattgcaaaa    360

tgtcctttaa gaacaaaaac tgggcacatt ctaaaatcaa cacaagatac ttgtattggg    420

agtgaaaaac ttttgcaaaa gaagccagtt ggttcagaaa catcacaggc aaaagaaaga    480

gatttcacct gcaaccccta atatgcagaa gactagaaac accgtaaata catctctagt    540

aggtaaacag aagcctcaca aaaaacacat cacagctgaa aacatgaaga gcagtttggt    600

gtgtctaaca caagaccaac tacaacagat tttgatgact gtaaaccaag gaaatagatc    660

tctttccctg actgagaatg gaaaggaggc aaaaagtaag atttttctaa agttttcatg    720

aattttgatt ttttcaatat gtgttttaga atatcagatt cattgggttt tatgtaactg    780

tgactcttaa actctaattt aacctgtcaa tctattaaaa taattgttct tttagaggac    840

tttctctaat atgcaaaatt atttttatag ttgtgccata ttttaaggtt agtgttcaga    900

atattaagaa acctagtttc tgtggatttt agaaaaaatg ttagtacaaa aaactattat    960

tatacttatt ttagaatata ggaggcttta ctcatattta aaatagtta               1009


<210>  1551
<211>  60
<212>  PRT
<213>  Homo sapiens

<400>  1551


Met Asn Leu Gly Asp Gly Leu Lys Leu Glu Thr Glu Leu Leu Asp Gly 
1               5                   10                  15      


Lys Thr Lys Leu Ile Leu Ser Pro Tyr Glu His Lys Ser Lys Ile Ser 
            20                  25                  30          


Val Lys Cys Leu Lys Val Phe Ala Cys Leu Trp Ile Glu Pro Ser Leu 
        35                  40                  45              


Asp Asp Val Pro Leu Tyr Pro Ser Thr Leu Ser Pro 
    50                  55                  60  

<210>  1552
<211>  836
<212>  DNA
<213>  Homo sapiens

<400>  1552
ggcaaccgac gtacacaagg ggcttgagcg ttctgtggag agagtgcgag gtcaggccat     60

gaacttggga gatggtttaa agcttgaaac tgaattactg gatggaaaaa ccaagctaat    120

attgtctcca tatgaacata aatcaaaaat ttctgtgaag atgggaaata aggccaagat    180

tgcaaaatgt cctttaagaa caaaaactgg gcacattcta aaatcaacac aagatacttg    240

tattgggagt gaaaaacttt tgcaaaagaa gccagttggt tcagaaacat cacaggcaaa    300

agaaagagat ttcacctgca acccctaata tgcagaagac tagaaacacc gtaaatacat    360

ctctagtagg taaacagaag cctcacaaaa aacacatcac agctgaaaac atgaagagca    420

gtttggtgtg tctaacacaa gaccaactac aacagatttt gatgactgta aaccaaggaa    480

atagatctct ttccctgact gagaatggaa aggaggcaaa aagtaagatt tttctaaagt    540

tttcatgaat tttgattttt tcaatatgtg ttttagaata tcagattcat tgggttttat    600

gtaactgtga ctcttaaact ctaatttaac ctgtcaatct attaaaataa ttgttctttt    660

agaggacttt ctctaatatg caaaattatt tttatagttg tgccatattt taaggttagt    720

gttcagaata ttaagaaacc tagtttctgt ggattttaga aaaaatgtta gtacaaaaaa    780

ctattattat acttatttta gaatatagga ggctttactc atatttaaaa tagtta        836


<210>  1553
<211>  89
<212>  PRT
<213>  Homo sapiens

<400>  1553


Met Asn Leu Gly Asp Gly Leu Lys Leu Glu Thr Glu Leu Leu Asp Gly 
1               5                   10                  15      


Lys Thr Lys Leu Ile Leu Ser Pro Tyr Glu His Lys Ser Lys Ile Ser 
            20                  25                  30          


Val Lys Met Gly Asn Lys Ala Lys Ile Ala Lys Cys Pro Leu Arg Thr 
        35                  40                  45              


Lys Thr Gly His Ile Leu Lys Ser Thr Gln Asp Thr Cys Ile Gly Ser 
    50                  55                  60                  


Glu Lys Leu Leu Gln Lys Lys Pro Val Gly Ser Glu Thr Ser Gln Ala 
65                  70                  75                  80  


Lys Glu Arg Asp Phe Thr Cys Asn Pro 
                85                  

<210>  1554
<211>  439
<212>  DNA
<213>  Homo sapiens

<400>  1554
aaagcttgaa actgaattac tggatggaaa aaccaagcta atattgtctc catatgaaca     60

taaatcaaaa atttctgtga agtgtcttaa agtctttgct tgtctgtgga tagaacccag    120

tttggatgat gtaccacttt atccttcaac tctaagccct tgatggcttt acttgcaggt    180

ttaattaagg tgaagaagtt gctggagtac ccgaaatatc actcaataaa taggtgaaga    240

tgatcagaac aattccacaa actacatata aaaattgttt ctctttctct atcatatagt    300

tatataccat gtatgctccc caatcacaga ctacagattg tatgttattc ctaccccttt    360

ccctattaaa aattgcaact aactgctgtt atttgaaaca cattcacaaa tacagtggcc    420

tttatcaagt tcctagatg                                                 439


<210>  1555
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  1555


Met Tyr Ala Pro Gln Ser Gln Thr Thr Asp Cys Met Leu Phe Leu Pro 
1               5                   10                  15      


Leu Ser Leu Leu Lys Ile Ala Thr Asn Cys Cys Tyr Leu Lys His Ile 
            20                  25                  30          


His Lys Tyr Ser Gly Leu Tyr Gln Val Pro 
        35                  40          

<210>  1556
<211>  745
<212>  DNA
<213>  Homo sapiens

<400>  1556
ataatctaat gacataagat tcaaagctgg agtatagtgg agatgtccta taacaactat     60

aataaaagtt cctgaagtaa gataatttct agttgttgat gaagatttgc aagtattaag    120

agttagtttc ttatggttat attacctaaa tagcaaaatg gaaaaaagtt tagaggactg    180

atttatcaca gatcatataa agataattgg tgatttttct tggacagtta taaagaataa    240

gcttctggtg ttttaacaga tgggaaataa ggccaagatt gcaaaatgtc ctttaagaac    300

aaaaactggg cacattctaa aatcaacaca agatacttgt attgggagtg aaaaactttt    360

gcaaaagaag ccagttggtt cagaaacatc acaggcaaaa ggtgaaaaaa atggaatgac    420

tttttcatcc actaaggatt tatgtaaaca atgtatagat aaagactgtc ttcatatcca    480

gaaagagatt tcacctgcaa cccctaatat gcagaagact agaaacaccg taaatacatc    540

tctagtaggt aaacagaagc ctcacaaaaa acacatcaca gctgaaaaca tgaagagcag    600

tttggtgtgt ctaacacaag accaactaca acagattttg atgactgtaa accaaggaaa    660

tagatctctt tccctgactg agaatggaaa ggaggcaaaa actgggcata gagacaattc    720

atgaaaaggt tttccactga tttca                                          745


<210>  1557
<211>  154
<212>  PRT
<213>  Homo sapiens

<400>  1557


Met Gly Asn Lys Ala Lys Ile Ala Lys Cys Pro Leu Arg Thr Lys Thr 
1               5                   10                  15      


Gly His Ile Leu Lys Ser Thr Gln Asp Thr Cys Ile Gly Ser Glu Lys 
            20                  25                  30          


Leu Leu Gln Lys Lys Pro Val Gly Ser Glu Thr Ser Gln Ala Lys Gly 
        35                  40                  45              


Glu Lys Asn Gly Met Thr Phe Ser Ser Thr Lys Asp Leu Cys Lys Gln 
    50                  55                  60                  


Cys Ile Asp Lys Asp Cys Leu His Ile Gln Lys Glu Ile Ser Pro Ala 
65                  70                  75                  80  


Thr Pro Asn Met Gln Lys Thr Arg Asn Thr Val Asn Thr Ser Leu Val 
                85                  90                  95      


Gly Lys Gln Lys Pro His Lys Lys His Ile Thr Ala Glu Asn Met Lys 
            100                 105                 110         


Ser Ser Leu Val Cys Leu Thr Gln Asp Gln Leu Gln Gln Ile Leu Met 
        115                 120                 125             


Thr Val Asn Gln Gly Asn Arg Ser Leu Ser Leu Thr Glu Asn Gly Lys 
    130                 135                 140                 


Glu Ala Lys Thr Gly His Arg Asp Asn Ser 
145                 150                 

<210>  1558
<211>  3006
<212>  DNA
<213>  Homo sapiens

<400>  1558
agaagatgat tttaaataat tcctttttat ctttgtttgg agacaaggac tcattctgtt     60

gcacaggcta gagtgcagtg gtgccatcac agctcactgc aacctcatat tttttgtaga    120

catggaatct cgctttgttg cccaggctgg tcttgctgcc ttcagatgac tctcccacct    180

tggcctccca aagtgttggg attacaggtg tgagtcactg cacccagcct aaatgattgc    240

ctatttttaa taccttcaat atacctacta ttcttgtagg aatatcagac tttaaactag    300

tataatttta taaataggaa tgcttaattt atgtggaaaa ttgcaataaa agcagaacta    360

aaggttaaaa tgtgttaatg ttaaaataat aggtaaaatg tgtacttttt gtgtctattt    420

ttaccgagaa caattattaa atgatctccc taaattcagt aactgatagg aatgtgggta    480

ctttttgtaa gaaaattttt attgcagtgt tcattctgat taagtgaaaa ttattgtatt    540

tagttgctgc tatacataat ttttattaat attccttaag tgttgtttta tcaggtgatt    600

tctctttgcc agttgataca atacaaatgg aatataatgc atctaacatt tcaaattcaa    660

gacatgattc tgatgaaatc agtggtaaaa tgaatacata tatgaattct acgacttcta    720

agaaggatac tggtgtgcaa acaggtattt gtgtggaaat tgtggtttgg tttaaaattt    780

acttaaagtc ataattaaag cagttagaat taagttcaat ttaaaagttc aaaaattaac    840

aaaacttgag gttttcagta agagttacaa aataaaggga taacagcttt gttgaaacat    900

gtcatgtacc acaaaattta tcctacagtt tagtcttttt tggtattcag tggtgcaacc    960

attaccacaa tcaattctaa aacattttga tcactctaga aacactgtac ccattacttg   1020

ccactttcta tttctctttt ctcctccagt taacattctg tctctgaata tttttgcctg   1080

ttgtggacat ttcacgtaac tggaattaga ccacataacg gtcttctctg gcttctttct   1140

ctcttagcat gttttaaggt tcatccatgt tgtagcatgt gtcagtactt cattcctgtt   1200

tgtcactgaa taaatattac atttataata ccacattttt attcatgagt tgatgaacat   1260

ttgggttatc tccacttttt ggctatgaat atgctgctgt gaacattcat atatagattt   1320

ttgtggatgt acatttttag ttcgagagaa gagtagaatt gctgagtcat gagtaacagg   1380

tactgtatgt ttagcatttt gaggaaccac caaactcttc tccaaagcag tggtaccatt   1440

ttacattccc accatcagtg catgtgggtt ctgattctct atatccttgc cagcccttgt   1500

tattctactg gttgtgaagt ggtatctcag gtggttttgg tttgcatttc ccccccagtg   1560

actgatgatg ttgagcatct tttcatgatt atcagttcat agaaatggaa attagagtgg   1620

tggctgccag tggttgggag tatgtggttg ttctttaatg agtatagagg ttcggttttg   1680

ttgaaaatta atgaaagaaa aaagtcttag agggcaataa ttgtttaatg ttttggggaa   1740

aattatttaa tattgaaaat tttgtttaca atttttaaaa atcatttgca actttttttt   1800

agatgactta aatataggaa tattcaccaa tgcagaatca cattgtggat cattaatgga   1860

gagggacatc acaaattgtt catctcctga gatttcggca gaacttattg gacagtttag   1920

caccaagaaa aacaagcaag aactaactca ggataaagga gccagcttag aaaaagaaaa   1980

caatcggtgt aatgaccagt gtaatcagtt cacaagaata gagaaacaaa caaaacacat   2040

gaagaaatat cctaaaaggc ctgattggaa tataaataag ccacctaaaa ggtatattcc   2100

agcatcagaa aagtacccta aacagcttca aaagcagaga gaagaaaaaa aagtaaggag   2160

gcagatggaa ttgcttcatt tggtagaaaa aaataatcct gggcacctct ctcaaaacag   2220

aggcatttca ccagaaattt ttcattcatc tcatcaagaa acggagtcaa agttgaggtg   2280

gcatctagtc aaaaaggaag aagagcctct gaatattcat tcattcagca aggaaaggtc   2340

tccatcatca ccagttccag tagtgaaaaa cagaacccaa caaactcaaa atacattaca   2400

tttaccacta aaaaacagta gctatgagag agagaatttg atctcaggaa gtaatcaaac   2460

agaattatca tctgggattt ctgaatcatc ccattttatt ccgtatgttc gaacaaatga   2520

gatctattac cttgatcccg atgcaccatt gtctgggcct tcaacccagg accctcagta   2580

ccaaaattca caagactgtg gccaaaaacg acagctattt gattctgact gtgtcaggga   2640

tccacttctt aatcctaaca tggtgaaaaa tagggatcga cagcaagcaa tccttaaggg   2700

actttcagaa ctgagacagg gccttctcca gaagcaaaag gagttggaaa gtagtctcct   2760

gcctttagct gaaaatcaag aagagagttt tggttcttca ttttaaatgt agaaaatcaa   2820

atccttcaca tttgatttgt gtcttccaaa ttataaaatg tgctcactgg ctcaactgta   2880

tttttcaaat agcctagatt tacttatttt tttaaatgct cattaaaaac ttgtatacta   2940

tgtagtaaaa tgctgtactt gttctataca ataaaacaga tacttctttt gtaaaagctt   3000

agtagt                                                              3006


<210>  1559
<211>  316
<212>  PRT
<213>  Homo sapiens

<400>  1559


Met Glu Arg Asp Ile Thr Asn Cys Ser Ser Pro Glu Ile Ser Ala Glu 
1               5                   10                  15      


Leu Ile Gly Gln Phe Ser Thr Lys Lys Asn Lys Gln Glu Leu Thr Gln 
            20                  25                  30          


Asp Lys Gly Ala Ser Leu Glu Lys Glu Asn Asn Arg Cys Asn Asp Gln 
        35                  40                  45              


Cys Asn Gln Phe Thr Arg Ile Glu Lys Gln Thr Lys His Met Lys Lys 
    50                  55                  60                  


Tyr Pro Lys Arg Pro Asp Trp Asn Ile Asn Lys Pro Pro Lys Arg Tyr 
65                  70                  75                  80  


Ile Pro Ala Ser Glu Lys Tyr Pro Lys Gln Leu Gln Lys Gln Arg Glu 
                85                  90                  95      


Glu Lys Lys Val Arg Arg Gln Met Glu Leu Leu His Leu Val Glu Lys 
            100                 105                 110         


Asn Asn Pro Gly His Leu Ser Gln Asn Arg Gly Ile Ser Pro Glu Ile 
        115                 120                 125             


Phe His Ser Ser His Gln Glu Thr Glu Ser Lys Leu Arg Trp His Leu 
    130                 135                 140                 


Val Lys Lys Glu Glu Glu Pro Leu Asn Ile His Ser Phe Ser Lys Glu 
145                 150                 155                 160 


Arg Ser Pro Ser Ser Pro Val Pro Val Val Lys Asn Arg Thr Gln Gln 
                165                 170                 175     


Thr Gln Asn Thr Leu His Leu Pro Leu Lys Asn Ser Ser Tyr Glu Arg 
            180                 185                 190         


Glu Asn Leu Ile Ser Gly Ser Asn Gln Thr Glu Leu Ser Ser Gly Ile 
        195                 200                 205             


Ser Glu Ser Ser His Phe Ile Pro Tyr Val Arg Thr Asn Glu Ile Tyr 
    210                 215                 220                 


Tyr Leu Asp Pro Asp Ala Pro Leu Ser Gly Pro Ser Thr Gln Asp Pro 
225                 230                 235                 240 


Gln Tyr Gln Asn Ser Gln Asp Cys Gly Gln Lys Arg Gln Leu Phe Asp 
                245                 250                 255     


Ser Asp Cys Val Arg Asp Pro Leu Leu Asn Pro Asn Met Val Lys Asn 
            260                 265                 270         


Arg Asp Arg Gln Gln Ala Ile Leu Lys Gly Leu Ser Glu Leu Arg Gln 
        275                 280                 285             


Gly Leu Leu Gln Lys Gln Lys Glu Leu Glu Ser Ser Leu Leu Pro Leu 
    290                 295                 300                 


Ala Glu Asn Gln Glu Glu Ser Phe Gly Ser Ser Phe 
305                 310                 315     

<210>  1560
<211>  3937
<212>  DNA
<213>  Homo sapiens

<400>  1560
agaagatgat tttaaataat tcctttttat ctttgtttgg agacaaggac tcattctgtt     60

gcacaggcta gagtgcagtg gtgccatcac agctcactgc aacctcatat tttttgtaga    120

catggaatct cgctttgttg cccaggctgg tcttgctgcc ttcagatgac tctcccacct    180

tggcctccca aagtgttggg attacaggtg tgagtcactg cacccagcct aaatgattgc    240

ctatttttaa taccttcaat atacctacta ttcttgtagg aatatcagac tttaaactag    300

tataatttta taaataggaa tgcttaattt atgtggaaaa ttgcaataaa agcagaacta    360

aaggttaaaa tgtgttaatg ttaaaataat aggtaaaatg tgtacttttt gtgtctattt    420

ttaccgagaa caattattaa atgatctccc taaattcagt aactgatagg aatgtgggta    480

ctttttgtaa gaaaattttt attgcagtgt tcattctgat taagtgaaaa ttattgtatt    540

tagttgctgc tatacataat ttttattaat attccttaag tgttgtttta tcaggtgatt    600

tctctttgcc agttgataca atacaaatgg aatataatgc atctaacatt tcaaattcaa    660

gacatgattc tgatgaaatc agtggtaaaa tgaatacata tatgaattct acgacttcta    720

agaaggatac tggtgtgcaa acaggtattt gtgtggaaat tgtggtttgg tttaaaattt    780

acttaaagtc ataattaaag cagttagaat taagttcaat ttaaaagttc aaaaattaac    840

aaaacttgag gttttcagta agagttacaa aataaaggga taacagcttt gttgaaacat    900

gtcatgtacc acaaaattta tcctacagtt tagtcttttt tggtattcag tggtgcaacc    960

attaccacaa tcaattctaa aacattttga tcactctaga aacactgtac ccattacttg   1020

ccactttcta tttctctttt ctcctccagt taacattctg tctctgaata tttttgcctg   1080

ttgtggacat ttcacgtaac tggaattaga ccacataacg gtcttctctg gcttctttct   1140

ctcttagcat gttttaaggt tcatccatgt tgtagcatgt gtcagtactt cattcctgtt   1200

tgtcactgaa taaatattac atttataata ccacattttt attcatgagt tgatgaacat   1260

ttgggttatc tccacttttt ggctatgaat atgctgctgt gaacattcat atatagattt   1320

ttgtggatgt acatttttag ttcgagagaa gagtagaatt gctgagtcat gagtaacagg   1380

tactgtatgt ttagcatttt gaggaaccac caaactcttc tccaaagcag tggtaccatt   1440

ttacattccc accatcagtg catgtgggtt ctgattctct atatccttgc cagcccttgt   1500

tattctactg gttgtgaagt ggtatctcag gtggttttgg tttgcatttc ccccccagtg   1560

actgatgatg ttgagcatct tttcatgatt atcagttcat agaaatggaa attagagtgg   1620

tggctgccag tggttgggag tatgtggttg ttctttaatg agtatagagg ttcggttttg   1680

ttgaaaatta atgaaagaaa aaagtcttag agggcaataa ttgtttaatg ttttggggaa   1740

aattatttaa tattgaaaat tttgtttaca atttttaaaa atcatttgca actttttttt   1800

agatgactta aatataggaa tattcaccaa tgcagaatca cattgtggat cattaatgga   1860

gagggacatc acaaattgtt catctcctga gatttcggca gaacttattg gacagtttag   1920

caccaagaaa aacaagcaag aactaactca ggataaagga gccagcttag aaaaagaaaa   1980

caatcggtgt aatgaccagt gtaatcagtt cacaagaata gagaaacaaa caaaacacat   2040

gaagaaatat cctaaaaggc ctgattggaa tataaataag ccacctaaaa ggtatattcc   2100

agcatcagaa aagtacccta aacagcttca aaagcagaga gaagaaaaaa aagtaaggag   2160

gcagatggaa ttgcttcatt tggtagaaaa aaataatcct gggcacctct ctcaaaacag   2220

aggcatttca ccagaaattt ttcattcatc tcatcaagaa acggagtcaa agttgaggtg   2280

gcatctagtc aaaaaggaag aagagcctct gaatattcat tcattcagca aggaaaggtc   2340

tccatcatca ccagttccag tagtgaaaaa cagaacccaa caaactcaaa atacattaca   2400

tttaccacta aaaaacagta gctatgagag agagaatttg atctcaggaa gtaatcaaac   2460

agaattatca tctgggattt ctgaatcatc ccattttatt ccgtatgttc gaacaaatga   2520

gatctattac cttgatcccg atgcaccatt gtctgggcct tcaacccagg accctcagta   2580

ccaaaattca caagactgtg gccaaaaacg acagctattt gattctgact gtgtcaggga   2640

tccacttctt aatcctaaca tggtgaaaaa tagggatcga cagcaagcaa tccttaaggg   2700

actttcagaa ctgagacagg gccttctcca gaagcaaaag gagttggaaa gtagtctcct   2760

gcctttagct gaaaatcaag aagagagttt tggttcttca ttttaaatgt agaaaatcaa   2820

atccttcaca tttgatttgt gtcttccaaa ttataaaatg tgctcactgg ctcaactgta   2880

tttttcaaat agcctagatt tacttatttt tttaaatgct cattaaaaac ttgtatacta   2940

tgtagtaaaa tgctgtactt gttctataca ataaaacaga tacttctttt gtaaaagctt   3000

agtagtaaaa aaaaaaaaaa aaaaaccggt tcttctgctc tgtcaccacc tgggtattga   3060

agccctataa aaacactttc tacttacctt aatatagtct ggcgttgctg ggacctcaca   3120

gtgttctttc acacttttta tgtaacttag gaactgaaat accactcatg catttgttct   3180

aaagtgccaa agttctgtct aacttattaa cacgtctaga cccataactc cataactttt   3240

actgaaataa cacaaattca gtttaggctc cttctctaaa tcctgacatt tatttgcact   3300

atgacattta tttgtagaaa ttgcaatttt caaaaacatt tttaaaagtt agcattagta   3360

acaagttagt aattagtatt agaggcagta gttaggaata gatacgggtt tgaaagctat   3420

ctccactgta tctgtctagt atagcattaa tgtgttcaac aaatggtaat tactactaag   3480

accacctcaa aaatatattc ccattatact tccattttgc taaaactaat ttaaaaatca   3540

aattgttcaa cgcctttgat aaacagaagc ctatcttttg aaataaaaaa tttaatttca   3600

ttaaatcaag gattgcgcag gtactgaaaa ttatccaata ctctcaaaaa gttaccagaa   3660

ttttagcaat aggcagtttt tacatgacta agcctagaga taaaaaatgt gtcctatgta   3720

catagtttat tatctaaatg aaactgcact gttagataaa tcttgaggta tcgagccaaa   3780

atcctgtaaa tattaacact gctattactg acttatacct gtgtaaacac agtatacaaa   3840

agcctacatc aaaataattc acttcaacaa aagtacttta tatcaggtga cattagagaa   3900

aaagaagtaa agcctttgct gtttaccgtc ctcctgc                            3937


<210>  1561
<211>  316
<212>  PRT
<213>  Homo sapiens

<400>  1561


Met Glu Arg Asp Ile Thr Asn Cys Ser Ser Pro Glu Ile Ser Ala Glu 
1               5                   10                  15      


Leu Ile Gly Gln Phe Ser Thr Lys Lys Asn Lys Gln Glu Leu Thr Gln 
            20                  25                  30          


Asp Lys Gly Ala Ser Leu Glu Lys Glu Asn Asn Arg Cys Asn Asp Gln 
        35                  40                  45              


Cys Asn Gln Phe Thr Arg Ile Glu Lys Gln Thr Lys His Met Lys Lys 
    50                  55                  60                  


Tyr Pro Lys Arg Pro Asp Trp Asn Ile Asn Lys Pro Pro Lys Arg Tyr 
65                  70                  75                  80  


Ile Pro Ala Ser Glu Lys Tyr Pro Lys Gln Leu Gln Lys Gln Arg Glu 
                85                  90                  95      


Glu Lys Lys Val Arg Arg Gln Met Glu Leu Leu His Leu Val Glu Lys 
            100                 105                 110         


Asn Asn Pro Gly His Leu Ser Gln Asn Arg Gly Ile Ser Pro Glu Ile 
        115                 120                 125             


Phe His Ser Ser His Gln Glu Thr Glu Ser Lys Leu Arg Trp His Leu 
    130                 135                 140                 


Val Lys Lys Glu Glu Glu Pro Leu Asn Ile His Ser Phe Ser Lys Glu 
145                 150                 155                 160 


Arg Ser Pro Ser Ser Pro Val Pro Val Val Lys Asn Arg Thr Gln Gln 
                165                 170                 175     


Thr Gln Asn Thr Leu His Leu Pro Leu Lys Asn Ser Ser Tyr Glu Arg 
            180                 185                 190         


Glu Asn Leu Ile Ser Gly Ser Asn Gln Thr Glu Leu Ser Ser Gly Ile 
        195                 200                 205             


Ser Glu Ser Ser His Phe Ile Pro Tyr Val Arg Thr Asn Glu Ile Tyr 
    210                 215                 220                 


Tyr Leu Asp Pro Asp Ala Pro Leu Ser Gly Pro Ser Thr Gln Asp Pro 
225                 230                 235                 240 


Gln Tyr Gln Asn Ser Gln Asp Cys Gly Gln Lys Arg Gln Leu Phe Asp 
                245                 250                 255     


Ser Asp Cys Val Arg Asp Pro Leu Leu Asn Pro Asn Met Val Lys Asn 
            260                 265                 270         


Arg Asp Arg Gln Gln Ala Ile Leu Lys Gly Leu Ser Glu Leu Arg Gln 
        275                 280                 285             


Gly Leu Leu Gln Lys Gln Lys Glu Leu Glu Ser Ser Leu Leu Pro Leu 
    290                 295                 300                 


Ala Glu Asn Gln Glu Glu Ser Phe Gly Ser Ser Phe 
305                 310                 315     

<210>  1562
<211>  2779
<212>  DNA
<213>  Homo sapiens

<400>  1562
ctttttttta gatgacttaa atataggaat attcaccaat gcagaatcac attgtggatc     60

attaatggag agggacatca caaattgttc atctcctgag atttcggcag aacttattgg    120

acagtttagc accaagaaaa acaagcaaga actaactcag gataaaggag ccagcttaga    180

aaaagaaaac aatcggtgta atgaccagtg taatcagttc acaagaatag agaaacaaac    240

aaaacacatg aagaaatatc ctaaaaggcc tgattggaat ataaataagc cacctaaaag    300

gtatattcca gcatcagaaa agtaccctaa acagcttcaa aagcagagag aagaaaaaaa    360

agtaaggagg cagatggaat tgcttcattt ggtagaaaaa aataatcctg ggcacctctc    420

tcaaaacaga ggcatttcac cagaaatttt tcattcatct catcaagaaa cggagtcaaa    480

gttgaggtgg catctagtca aaaaggtaaa gctcttccat cttagatgat gtgttgacgt    540

ttctggattc aaaacacagt ttctcatacg tatgctttgg taaggctgtt ctgatctgtt    600

tcagtttaca ttagggatca gcaaactata tcccatgggc aaatccaggc tgctgcctgt    660

ttttggaaag ttttatacga acatagtcaa ctcattcttt tatgaattgt ctgtggctga    720

cttcacacac cagactagca acagaaacaa tatggcccac aaagctgaaa aggtttcctt    780

atgcttatcg agtcctttac acttacacaa cttctgtaga tggatgctgt gtattcaaat    840

acccctttaa aacccttgtt tatagtccac atagacagag gtttgggaga ttaggaactc    900

ccaaggatta gttttgactc tggaaaaaac tatatctatt ccattgctca gtcagtacct    960

gttattcaaa tattaccctc agactatttc aacaagtagc cctaaaaata tttgtgggga   1020

catgtgaaga tgctatatat tcctttctgc atttatctat ccatatttta ggaagaagag   1080

cctctgaata ttcattcatt cagcaaggaa aggtaagtat gcatcagatt aattccgcag   1140

ctacttaatg ctttctatgt gggacaaaaa agggattcaa gatctggaca gcatcatatg   1200

gtatatgtag agaacaatca gaaagggtgt ggcttccagg tgagggttag aggtttaagg   1260

gatagtgtgg cactttagca ggagcttgaa ggcccaagtt ggactgggcc taggcaggaa   1320

tgtagataac atttactttt atctctagac ttaactaagt gattttgata ttccaggtat   1380

gtcattagca gaataggcat tctgctttgg gaggagggat ggctgggggc tgtgaatggg   1440

aagaaatgac tgataaggac aatgagaaat tcagtcagtt aatgagagat ttagaaccat   1500

tagaattttt attctttgtg catgaaccag ctggtttagt tgtctcagaa tggggctcta   1560

aaaacaagtt tcattcaaat ggtgagtaca ttattgtatg gtgaattatc taaggagaaa   1620

cagtaggctc agattaacca agccagcact gttcctcagg atctaggaat taaatttctc   1680

ccttgtgcta cagtacacat accatagcta gtgctagtaa aaacataaat gaataccatt   1740

ctcttccccg gttttatgga acaatattat agagttcagg cttctatgca tacattccca   1800

aaggtgttac aggtacattt agaataaagt gaaatgggcc aggcatgtgg ctcacgcctg   1860

taatcccagc actttgggag gccgaggcag gtggatccac ctgaggtcag gagttcaaga   1920

ccagcctggc caacttggtg aaccccgtct ctactaaaaa tacagaaact agctgggcac   1980

tgtggcgtgc gcctgtaatc ccagctactt gggaggctga agcaggagag ttgcagtgag   2040

ctgagatcgc gccactgcac tccagcctgg gcaacagagc gagacttcat ctcataaata   2100

aagtgaaatg tgattaaaga gatatactta atctaaatac acaatttttt actatttttt   2160

ttttaaatag gtctccatca tcaccagttc cagtagtgaa aaacagaacc caacaaactc   2220

aaaatacatt acatttacca ctaaaaaaca gtagctatga gagagagaat ttgatctcag   2280

gaagtaatca aacagaatta tcatctggga tttctgaatc atcccatttt attccgtatg   2340

ttcgaacaaa tgagatctat taccttgatc ccgatgcacc attgtctggg ccttcaaccc   2400

aggaccctca gtaccaaaat tcacaagact gtggccaaaa acgacagcta tttgattctg   2460

actgtgtcag ggatccactt cttaatccta acatggtgaa aaatagggat cgacagcaag   2520

caatccttaa gggactttca gaactgagac agggccttct ccagaagcaa aaggagttgg   2580

aaagtagtct cctgccttta gctgaaaatc aagaagagag ttttggttct tcattttaaa   2640

tgtagaaaat caaatccttc acatttgatt tgtgtcttcc aaattataaa atgtgctcac   2700

tggctcaact gtatttttca aatagcctag atttacttat ttttttaaat gctcattaaa   2760

aacttgtata ctatgtagt                                                2779


<210>  1563
<211>  53
<212>  PRT
<213>  Homo sapiens

<400>  1563


Met Phe Glu Gln Met Arg Ser Ile Thr Leu Ile Pro Met His His Cys 
1               5                   10                  15      


Leu Gly Leu Gln Pro Arg Thr Leu Ser Thr Lys Ile His Lys Thr Val 
            20                  25                  30          


Ala Lys Asn Asp Ser Tyr Leu Ile Leu Thr Val Ser Gly Ile His Phe 
        35                  40                  45              


Leu Ile Leu Thr Trp 
    50              

<210>  1564
<211>  7535
<212>  DNA
<213>  Homo sapiens

<400>  1564
aatgactgtt aatttctttg cctcctcttt gattccatct cttgacctct atatcatttc     60

aaaggagcat tgagtgaaca tccatccttg taccttgaat attccatgaa tgctcctgct    120

tcagggcctc tgcatttgct gttctctcac tttccccagt aagctgcata attcattcta    180

catttcttca cgtatttcct tatgattgag gtttctctgt tttttttttt tacctctata    240

ctcttatgtc tctttttata gcactgaaaa ccatcatgat ctgttatata tcattgtttt    300

ctgtcttcct cattagattt atgtaggttg gaactttgtt ctgtttatct ctataatcct    360

attacctaga actgtgcctg gtaaataaga gcttagtatg tatttactga atgatgaatt    420

aatatattta tatattgagg ctgtgtcttc taatgtcagc aaaataattg acaagagact    480

ttggtggaca ctgttctctc ttggttaata tttttggaaa aaacaactcc cttaaatttg    540

ggtaaatgtg gtaatttgag cgaagtaagt acttctgttt tctctaagta gacttggatt    600

tactagactt tgtaatgagt aatttctttg ttcttcctac ctggaggaag gacttaactg    660

tagtatgcca ttaaaaattg cacttatatc atcttacatg ttaattttta tgattatact    720

aatgagtaat gtttttcttt tcttttaaaa aatttgtaga tctaacagct ttaatacaga    780

tagaaacata gataaatata actatacctt gtggaaagga cagcttttaa ataaaggaaa    840

acttttgtgt tatatttctc tgaggtcagc cactcgtgct tttttgccta tcaaactacc    900

tgagaaatta gatgttgaaa cagttatgag tattgatcat ctgaaacaga aaatccctcc    960

agcactgttt tataaggaaa catacttagg tccaaatgaa gttttgaaga atggaatgta   1020

ttgcagcctt tatgaagttg tggaaaagac aagaattgga agtaacatgg agagtttact   1080

gcaaaaacta gacagagaaa aacttgttct tgttaaacct ttgggagacc gaggatacct   1140

ttttcttctc tccccttatc agatggttcc tccatatgaa tatcagactg ccaagtctcg   1200

agtcctacat gctttgtttc tatttcaaga acctagaagc atagttactt cacaaaaagg   1260

ttcaaccaat gcagcaccac aggagaggca tgagagcatg ccagatgtat taaaaatagc   1320

tcagttttta caattttctt tgattcagtg tcgaaaggaa ttcaaaaata taagcgccat   1380

aaattttcat tctgttgttg aaaagtatgt aagtgaattt tttaagcgag gttttggttc   1440

aggtaaacga gagtttatta tgtttccata tgattcacga ttagatgata aaaaattctt   1500

atactcagct cccagaaata aatcccatat tgatacttgt ttgcatgcct atatttttcg   1560

gcctgaagtg tatcagttac ctatttgtaa attaaaagaa ctatttgaag aaaatagaaa   1620

acttcagcag tttagtccac tttcagatta tgaaggtcaa gaagaagaaa tgaatggtac   1680

aaaaatgaaa tttggaaaac gaaataactc aagaggtgaa gccattatat ctggaaagca   1740

aagatcatct cattctttgg attatgataa ggatagagtc aaagaattga ttaatttaat   1800

tcagtgtagg aaaaagagtg tgggtgggga ctcagacaca gaagatatga gaagcaaaac   1860

tgtcttgaag aggaagcttg aggatctacc tgaaaatatg agaaagctcg ccaaaaccag   1920

taatttatct gaaaattgcc atctgtatga agagtctcca cagcctattg gctcacttgg   1980

acatgatgct gacttgaggc ggcagcagca ggatacctgt aactccggca ttgctgacat   2040

ccataggctg tttaattggt tatcagaaac actagcaaat gcgcgccatt ctgatgcatc   2100

tctgacagac acagtcaaca aagccttagg attgagcact gatgatgcct atgaagagct   2160

gaggcaaaaa catgagtatg agttgaactc taccccagat aagaaagact atgagcagcc   2220

tacttgtgca aaagttgaaa atgcacagtt taagggtact cagagcttat tactagaagt   2280

tgatgcaaca tctaagtatt ctgttgctat ttctaccagc gaagtgggca ctgaccataa   2340

gctacatttg aaagaagatc caaatttaat tagcgtgaat aattttgaag attgcagttt   2400

gtgtcccagt gttcccattg aacatggatt tcgtagacaa cagtctaagt caaataatgt   2460

tgaagagact gaaatacatt ggaaactgat tccaattaca ggagggaatg caagaagccc   2520

agaagaccag ctggggaaac atggtgagaa acaaacacca gacacactaa agggcaccac   2580

tgaggatgac gtgttgacag gtcaggtgga ggagcagtgt gtgccagcag cagaggcaga   2640

gccgcctgca gtgagcgaaa ccacagagag gacagtgtta ggagagtaca atctcttttc   2700

taggaagata gaagagattt tgaagcaaaa gaatgtttca tatgtcagta cagtttccac   2760

acctatcttt tcaacacaag agaagatgaa acggctttcc gagttcatat attctaagac   2820

ttccaaagct ggtgtgcagg agtttgtaga tggtttgcat gagaagctaa atactattat   2880

tattaaagca tcagccaagg gtgggaattt gccaccagtc agtcctaacg attctggtgc   2940

taagatagca tcgaatcctc tggaaaggca tgtcatacca gtttcctcaa gtgacttcaa   3000

caataaacat ctccttgagc cactgtgtag tgatcctttg aaagatacca actctgatga   3060

gcagcattcc acttcggctt taactgaagt agaaatgaac cagcctcaac atgccacaga   3120

gttaatggtg acttctgatc atattgtacc tggtgatatg gcccgggaac cagtagaaga   3180

aacaacaaaa tcccccagtg atgtaaacat ttctgctcaa ccagctcttt caaattttat   3240

aagccagtta gaacctgaag tatttaatag tttggttaaa atcatgaaag acgtccagaa   3300

aaatactgtg aaattttata ttcatgaaga agaagagagt gtgctctgta aagaaataaa   3360

ggaatatctt atcaaattag gcaatacaga atgtcatcct gaacagtttt tggaaagaag   3420

atcaaaatta gataaactat tgattattat tcaaaatgaa gacattgcag gtttcattca   3480

caagatacct ggcttggtga ctttaaagaa gctcccctgt gttagttttg ctggtgttga   3540

tagcctggat gatgttaaaa atcatacata caatgaatta tttgtatctg gaggttttat   3600

cgtatctgat gaatcaattc taaacccaga ggttgtcaca gttgagaacc ttaaaaattt   3660

tttgacattc cttgaggaac ttagtactcc agaaggaaaa tggcaatgga aagtccactg   3720

taaatttcag aagaaactaa aggaactagg cagattgaat gctaaagctc taagtctgtt   3780

gacgcttctg aatgtctatc agaagaaaca tctggttgaa attttgtcat accacaattg   3840

tgattcacaa actcgaaatg ctccagaatt ggattgcctt atcagacttc aggctcagaa   3900

catacagcaa cgacacatag tctttttaac agagaagaac atcaagatgc tttccagtta   3960

tacagataat ggaatagtgg ttgcaactgc tgaagacttc atgcaaaact ttaaaaatct   4020

tgtgggctat cacaattcaa tcacagaaga aaaccttcca cagcttggtg ctaatgagaa   4080

tcttgagtcg cagtcagctc ttttagaaaa cgatgaaaag gatgaagagg atatgtctct   4140

ggattcaggg gatgaaatct cacatataga agtatgcagc aattttcatt cagaaatatg   4200

ggagaaagag accaaaggat cacgtggaac agatcaaaaa aagaatactc aaattgagtt   4260

gcaatcgtct cctgatgtgc aaaacagttt attagaagat aagacttacc ttgattctga   4320

agagagaact tctattgata tagtatgctc tgaaggagag aacagcaatt caacagaaca   4380

agattcatat agtaactttc aggtttatca tagtcaatta aatatgtccc atcagtttag   4440

tcattttaat gttctcactc atcagacatt tttggggaca ccatatgccc tttcatcaag   4500

tcagtctcaa gaaaatgaga attacttctt atctgcttat actgaaagct tggatagaga   4560

taaatctcca cctcccttaa gttgggggaa aagtgattct tccaggccat attcacaaga   4620

gaaataactg tagtaacttt ttttttaaga gattgttgtg gactttgttt attaacaatt   4680

tatatttcat tctctaaaca aaaggttctt gttctttctc aaatgttttt tcttttattt   4740

aaatcatgat ggcctgtaac agttgaagca tctaaaaatt gaaataaata tatattttta   4800

acatatattg tacttgaatt atctcatgtt ggcacttcta agttttactt tttgtatgtt   4860

acctgtactt aggcttcaaa ttgaagcctg ttttatgtgt aaaatcagat gcttgcagga   4920

ggacggtaaa cagcaaaggc tttacttctt tttctctaat gtcacctgat ataaagtact   4980

tttgttgaag tgaattattt tgatgtaggc ttttgtatac tgtgtttaca caggtataag   5040

tcagtaatag cagtgttaat atttacagga ttttggctcg atacctcaag atttatctaa   5100

cagtgcagtt tcatttagat aataaactat gtacatagga cacatttttt atctctaggc   5160

ttagtcatgt aaaaactgcc tattgctaaa attctggtaa ctttttgaga gtattggata   5220

attttcagta cctgcgcaat ccttgattta atgaaattaa attttttatt tcaaaagata   5280

ggcttctgtt tatcaaaggc gttgaacaat ttgattttta aattagtttt agcaaaatgg   5340

aagtataatg ggaatatatt tttgaggtgg tcttagtagt aattaccatt tgttgaacac   5400

attaatgcta tactagacag atacagtgga gatagctttc aaacccgtat ctattcctaa   5460

ctactgcctc taatactaat tactaacttg ttactaatgc taacttttaa aaatgttttt   5520

gaaaattgca atttctacaa ataaatgtca tagtgcaaat aaatgtcagg atttagagaa   5580

ggagcctaaa ctgaatttgt gttatttcag taaaagttat ggagttatgg gtctagacgt   5640

gttaataagt tagacagaac tttggcactt tagaacaaat gcatgagtgg tatttcagtt   5700

cctaagttac ataaaaagtg tgaaagaaca ctgtgaggtc ccagcaacgc cagactatat   5760

taaggtaagt agaaagtgtt tttatagggc ttcaataccc aggtggtgac agagcagaag   5820

aaccggtttt tttttttttt tttttactac taagctttta caaaagaagt atctgtttta   5880

ttgtatagaa caagtacagc attttactac atagtataca agtttttaat gagcatttaa   5940

aaaaataagt aaatctaggc tatttgaaaa atacagttga gccagtgagc acattttata   6000

atttggaaga cacaaatcaa atgtgaagga tttgattttc tacatttaaa atgaagaacc   6060

aaaactctct tcttgatttt cagctaaagg caggagacta ctttccaact ccttttgctt   6120

ctggagaagg ccctgaaatc acattgatat atgtttgtta gtaaaatgtg cacacctgac   6180

ttgcaatgtt gtgttaaact agaattatat tcacttggaa aacatatcgc ttaggataaa   6240

attttgtcat tcaaaaattt tttcagaaat gcttgtacta gaccacctca tttggatata   6300

tagctatcac atttgtaaga ttctgttttt agcataaaaa tcaataggga tgaaaatttt   6360

cttagaactc aagactccat aactatgggg gtaaatgaag tcatcccttc tcccccagtc   6420

cacccccaag tgctcttaga tactgaagga gtctccctta acatacagtg tttttttttt   6480

gttgttgttg ttttgttttt ttttggagat ggagtctcgc tctgtcgccc aagctggagt   6540

acagtggtgc aatctcactg caagctctgc ctcccaggtt cacaccattc tcctgcctca   6600

acctcccgaa tggctgggac tacaggcacc caccaccacg cctggctaac taactaacta   6660

actttttgta tttttagtag agacagggtt tcactgtgtt agccaggatg gtcttgatct   6720

cctgacctca tgatctgcct gcctcagcct cccaaagtgc tgggattaca ggcttgagcc   6780

actgctcctg gccaacatcc agtattttat cttgactgtc ctaaccttac cttagatgct   6840

aacagaaggg tcctgctgaa ataacactgg gtgctatatt gatgggtaaa tgtgtacatc   6900

ctattccttc ctctttatct cacaattttt gtctccacta agcaagaagt aaactaacac   6960

ttcgtcactc taaagaaata acttatgtaa aactcttagt aaccctgttt gtcttcaaat   7020

gagtaaatag accaaagtgg ggggacaatt ttctagttct gtagagggaa aaacatctga   7080

gtcaacattt tgaaatgcag agggtattgg tacatgacga catggaaaag ggcactttta   7140

aacacagctt actcttcctc aagtacagag agtatatagt gaatcaaaac taactacagc   7200

cattcttttt aaagcccaag ggatggagca aaggtgtaag gatgttacct gtttgtttta   7260

atcagagagc aaaaagaagt cacaatagtt tgggagaaaa agtagtatgg tgagtaaggt   7320

tatgcgtata atttcatact gaatttatta ctatttggga tgtacgtcaa tgttctaaca   7380

aacactgcca acacgtcaat tttttaaaaa gcgtgggcca cattgctaag aatttgttaa   7440

agcataactg tattttttgt tttagggcct tattgatgtt ttgccgttcc aatgtatgca   7500

tttttttact caataaactt gtcttaattt tagaa                              7535


<210>  1565
<211>  1233
<212>  PRT
<213>  Homo sapiens

<400>  1565


Met Ser Ile Asp His Leu Lys Gln Lys Ile Pro Pro Ala Leu Phe Tyr 
1               5                   10                  15      


Lys Glu Thr Tyr Leu Gly Pro Asn Glu Val Leu Lys Asn Gly Met Tyr 
            20                  25                  30          


Cys Ser Leu Tyr Glu Val Val Glu Lys Thr Arg Ile Gly Ser Asn Met 
        35                  40                  45              


Glu Ser Leu Leu Gln Lys Leu Asp Arg Glu Lys Leu Val Leu Val Lys 
    50                  55                  60                  


Pro Leu Gly Asp Arg Gly Tyr Leu Phe Leu Leu Ser Pro Tyr Gln Met 
65                  70                  75                  80  


Val Pro Pro Tyr Glu Tyr Gln Thr Ala Lys Ser Arg Val Leu His Ala 
                85                  90                  95      


Leu Phe Leu Phe Gln Glu Pro Arg Ser Ile Val Thr Ser Gln Lys Gly 
            100                 105                 110         


Ser Thr Asn Ala Ala Pro Gln Glu Arg His Glu Ser Met Pro Asp Val 
        115                 120                 125             


Leu Lys Ile Ala Gln Phe Leu Gln Phe Ser Leu Ile Gln Cys Arg Lys 
    130                 135                 140                 


Glu Phe Lys Asn Ile Ser Ala Ile Asn Phe His Ser Val Val Glu Lys 
145                 150                 155                 160 


Tyr Val Ser Glu Phe Phe Lys Arg Gly Phe Gly Ser Gly Lys Arg Glu 
                165                 170                 175     


Phe Ile Met Phe Pro Tyr Asp Ser Arg Leu Asp Asp Lys Lys Phe Leu 
            180                 185                 190         


Tyr Ser Ala Pro Arg Asn Lys Ser His Ile Asp Thr Cys Leu His Ala 
        195                 200                 205             


Tyr Ile Phe Arg Pro Glu Val Tyr Gln Leu Pro Ile Cys Lys Leu Lys 
    210                 215                 220                 


Glu Leu Phe Glu Glu Asn Arg Lys Leu Gln Gln Phe Ser Pro Leu Ser 
225                 230                 235                 240 


Asp Tyr Glu Gly Gln Glu Glu Glu Met Asn Gly Thr Lys Met Lys Phe 
                245                 250                 255     


Gly Lys Arg Asn Asn Ser Arg Gly Glu Ala Ile Ile Ser Gly Lys Gln 
            260                 265                 270         


Arg Ser Ser His Ser Leu Asp Tyr Asp Lys Asp Arg Val Lys Glu Leu 
        275                 280                 285             


Ile Asn Leu Ile Gln Cys Arg Lys Lys Ser Val Gly Gly Asp Ser Asp 
    290                 295                 300                 


Thr Glu Asp Met Arg Ser Lys Thr Val Leu Lys Arg Lys Leu Glu Asp 
305                 310                 315                 320 


Leu Pro Glu Asn Met Arg Lys Leu Ala Lys Thr Ser Asn Leu Ser Glu 
                325                 330                 335     


Asn Cys His Leu Tyr Glu Glu Ser Pro Gln Pro Ile Gly Ser Leu Gly 
            340                 345                 350         


His Asp Ala Asp Leu Arg Arg Gln Gln Gln Asp Thr Cys Asn Ser Gly 
        355                 360                 365             


Ile Ala Asp Ile His Arg Leu Phe Asn Trp Leu Ser Glu Thr Leu Ala 
    370                 375                 380                 


Asn Ala Arg His Ser Asp Ala Ser Leu Thr Asp Thr Val Asn Lys Ala 
385                 390                 395                 400 


Leu Gly Leu Ser Thr Asp Asp Ala Tyr Glu Glu Leu Arg Gln Lys His 
                405                 410                 415     


Glu Tyr Glu Leu Asn Ser Thr Pro Asp Lys Lys Asp Tyr Glu Gln Pro 
            420                 425                 430         


Thr Cys Ala Lys Val Glu Asn Ala Gln Phe Lys Gly Thr Gln Ser Leu 
        435                 440                 445             


Leu Leu Glu Val Asp Ala Thr Ser Lys Tyr Ser Val Ala Ile Ser Thr 
    450                 455                 460                 


Ser Glu Val Gly Thr Asp His Lys Leu His Leu Lys Glu Asp Pro Asn 
465                 470                 475                 480 


Leu Ile Ser Val Asn Asn Phe Glu Asp Cys Ser Leu Cys Pro Ser Val 
                485                 490                 495     


Pro Ile Glu His Gly Phe Arg Arg Gln Gln Ser Lys Ser Asn Asn Val 
            500                 505                 510         


Glu Glu Thr Glu Ile His Trp Lys Leu Ile Pro Ile Thr Gly Gly Asn 
        515                 520                 525             


Ala Arg Ser Pro Glu Asp Gln Leu Gly Lys His Gly Glu Lys Gln Thr 
    530                 535                 540                 


Pro Asp Thr Leu Lys Gly Thr Thr Glu Asp Asp Val Leu Thr Gly Gln 
545                 550                 555                 560 


Val Glu Glu Gln Cys Val Pro Ala Ala Glu Ala Glu Pro Pro Ala Val 
                565                 570                 575     


Ser Glu Thr Thr Glu Arg Thr Val Leu Gly Glu Tyr Asn Leu Phe Ser 
            580                 585                 590         


Arg Lys Ile Glu Glu Ile Leu Lys Gln Lys Asn Val Ser Tyr Val Ser 
        595                 600                 605             


Thr Val Ser Thr Pro Ile Phe Ser Thr Gln Glu Lys Met Lys Arg Leu 
    610                 615                 620                 


Ser Glu Phe Ile Tyr Ser Lys Thr Ser Lys Ala Gly Val Gln Glu Phe 
625                 630                 635                 640 


Val Asp Gly Leu His Glu Lys Leu Asn Thr Ile Ile Ile Lys Ala Ser 
                645                 650                 655     


Ala Lys Gly Gly Asn Leu Pro Pro Val Ser Pro Asn Asp Ser Gly Ala 
            660                 665                 670         


Lys Ile Ala Ser Asn Pro Leu Glu Arg His Val Ile Pro Val Ser Ser 
        675                 680                 685             


Ser Asp Phe Asn Asn Lys His Leu Leu Glu Pro Leu Cys Ser Asp Pro 
    690                 695                 700                 


Leu Lys Asp Thr Asn Ser Asp Glu Gln His Ser Thr Ser Ala Leu Thr 
705                 710                 715                 720 


Glu Val Glu Met Asn Gln Pro Gln His Ala Thr Glu Leu Met Val Thr 
                725                 730                 735     


Ser Asp His Ile Val Pro Gly Asp Met Ala Arg Glu Pro Val Glu Glu 
            740                 745                 750         


Thr Thr Lys Ser Pro Ser Asp Val Asn Ile Ser Ala Gln Pro Ala Leu 
        755                 760                 765             


Ser Asn Phe Ile Ser Gln Leu Glu Pro Glu Val Phe Asn Ser Leu Val 
    770                 775                 780                 


Lys Ile Met Lys Asp Val Gln Lys Asn Thr Val Lys Phe Tyr Ile His 
785                 790                 795                 800 


Glu Glu Glu Glu Ser Val Leu Cys Lys Glu Ile Lys Glu Tyr Leu Ile 
                805                 810                 815     


Lys Leu Gly Asn Thr Glu Cys His Pro Glu Gln Phe Leu Glu Arg Arg 
            820                 825                 830         


Ser Lys Leu Asp Lys Leu Leu Ile Ile Ile Gln Asn Glu Asp Ile Ala 
        835                 840                 845             


Gly Phe Ile His Lys Ile Pro Gly Leu Val Thr Leu Lys Lys Leu Pro 
    850                 855                 860                 


Cys Val Ser Phe Ala Gly Val Asp Ser Leu Asp Asp Val Lys Asn His 
865                 870                 875                 880 


Thr Tyr Asn Glu Leu Phe Val Ser Gly Gly Phe Ile Val Ser Asp Glu 
                885                 890                 895     


Ser Ile Leu Asn Pro Glu Val Val Thr Val Glu Asn Leu Lys Asn Phe 
            900                 905                 910         


Leu Thr Phe Leu Glu Glu Leu Ser Thr Pro Glu Gly Lys Trp Gln Trp 
        915                 920                 925             


Lys Val His Cys Lys Phe Gln Lys Lys Leu Lys Glu Leu Gly Arg Leu 
    930                 935                 940                 


Asn Ala Lys Ala Leu Ser Leu Leu Thr Leu Leu Asn Val Tyr Gln Lys 
945                 950                 955                 960 


Lys His Leu Val Glu Ile Leu Ser Tyr His Asn Cys Asp Ser Gln Thr 
                965                 970                 975     


Arg Asn Ala Pro Glu Leu Asp Cys Leu Ile Arg Leu Gln Ala Gln Asn 
            980                 985                 990         


Ile Gln Gln Arg His Ile Val Phe  Leu Thr Glu Lys Asn  Ile Lys Met 
        995                 1000                 1005             


Leu Ser  Ser Tyr Thr Asp Asn  Gly Ile Val Val Ala  Thr Ala Glu 
    1010                 1015                 1020             


Asp Phe  Met Gln Asn Phe Lys  Asn Leu Val Gly Tyr  His Asn Ser 
    1025                 1030                 1035             


Ile Thr  Glu Glu Asn Leu Pro  Gln Leu Gly Ala Asn  Glu Asn Leu 
    1040                 1045                 1050             


Glu Ser  Gln Ser Ala Leu Leu  Glu Asn Asp Glu Lys  Asp Glu Glu 
    1055                 1060                 1065             


Asp Met  Ser Leu Asp Ser Gly  Asp Glu Ile Ser His  Ile Glu Val 
    1070                 1075                 1080             


Cys Ser  Asn Phe His Ser Glu  Ile Trp Glu Lys Glu  Thr Lys Gly 
    1085                 1090                 1095             


Ser Arg  Gly Thr Asp Gln Lys  Lys Asn Thr Gln Ile  Glu Leu Gln 
    1100                 1105                 1110             


Ser Ser  Pro Asp Val Gln Asn  Ser Leu Leu Glu Asp  Lys Thr Tyr 
    1115                 1120                 1125             


Leu Asp  Ser Glu Glu Arg Thr  Ser Ile Asp Ile Val  Cys Ser Glu 
    1130                 1135                 1140             


Gly Glu  Asn Ser Asn Ser Thr  Glu Gln Asp Ser Tyr  Ser Asn Phe 
    1145                 1150                 1155             


Gln Val  Tyr His Ser Gln Leu  Asn Met Ser His Gln  Phe Ser His 
    1160                 1165                 1170             


Phe Asn  Val Leu Thr His Gln  Thr Phe Leu Gly Thr  Pro Tyr Ala 
    1175                 1180                 1185             


Leu Ser  Ser Ser Gln Ser Gln  Glu Asn Glu Asn Tyr  Phe Leu Ser 
    1190                 1195                 1200             


Ala Tyr  Thr Glu Ser Leu Asp  Arg Asp Lys Ser Pro  Pro Pro Leu 
    1205                 1210                 1215             


Ser Trp  Gly Lys Ser Asp Ser  Ser Arg Pro Tyr Ser  Gln Glu Lys 
    1220                 1225                 1230             

<210>  1566
<211>  5183
<212>  DNA
<213>  Homo sapiens

<400>  1566
gacgcgcgca cgttgagtgg cgggggaagg cagaagaact gcccgaggga ggagcggctc     60

cgaggaccgg gcagcgcatt tggggtgccc gctacagggc cccccaagag gctgccaggt    120

cgggagcgca gcctgaggcc acggggggaa gggggtgggt gggctgagag cagctcggcg    180

gcgagactgg cccgccgccc cttcccccca cacccgtcga ccttgtgggc agaagcttcc    240

cagagctcct taggccggcg cgatggcgac tgctgtggag acggaggcct gtcagccgac    300

ggatgcgagt tgggaaagtg gcggcggcgg agacgacgag atgaagcagg cgcttccgga    360

gcttgagtcc tcccaacaaa atggcggcgg cggcggcctc aacatcgctg agcccagcgg    420

cggcgctggg cgtgaggaga acgcgggggc cgaggccgcc cagagcctca gccacgagca    480

gcctcaggac tcctctgagg cgggcgcggc cgccctgccc agaggccccg aagagcccga    540

aaggcctgtt aggaggagtt ttcagatccc caggaagagc agagaaaaga aagcactttt    600

ccagccatta actccaggct ctcgagaatt tgaagatgtt gtaaatattc tccattcttc    660

ttaccttgaa ccaacctcag taacaaattt taactacaga cgtgcttgct tggtacacaa    720

tgagcttttg gaaaaggagt ttacagaaaa gcgaagagaa ctgaagtttg atggtcgttt    780

agataaggaa ctttcagaat cctatgcatt tctgatggtt gatcgatacc aggttcaaac    840

catatgtgaa aaaggattac atgtgggtca gtccaaaata acaattcttg gcagtccttc    900

catgggtgtc tatctttcta ggtatgctga tttattacaa gcgaatcctt tggacacggg    960

ggcaatgggt gatgttgtta tttttaaaat aatgaagggt aaaataaaga gtatatatga   1020

ccccatgggt gtaaaaagtt tggaatctat gttaaataag agtgctttgg accccacacc   1080

aaagcatgaa tgtcacgtgt caaagaatgc caatcgaatt acatcacttt tggcttacag   1140

agcctatgag cttactcagt attattttta tgagtatggc tttgatgagc taaggcgaag   1200

accaagacac gtttgtccat atgcagttgt gtcttttact tacaaagatg atatacaaac   1260

tccgaagttt gtaccttcat caagatctaa cagctttaat acagatagaa acatagataa   1320

atataactat accttgtgga aaggacagct tttaaataaa ggaaaacttt tgtgttatat   1380

ttctctgagg tcagccactc gtgctttttt gcctatcaaa ctacctgaga aattagatgt   1440

tgaaacagtt atgagtattg atcatctgaa acagaaaatc cctccagcac tgttttataa   1500

ggaaacatac ttaggtccaa atgaagtttt gaagaatgga atgtattgca gcctttatga   1560

agttgtggaa aagacaagaa ttggaagtaa catggagagt ttactgcaaa aactagacag   1620

agaaaaactt gttcttgtta aacctttggg agaccgagga tacctttttc ttctctcccc   1680

ttatcagatg gttcctccat atgaatatca gactgccaag tctcgagtcc tacatgcttt   1740

gtttctattt caagaaccta gaagcatagt tacttcacaa aaaggttcaa ccaatgcagc   1800

accacaggag aggcatgaga gcatgccaga tgtattaaaa atagctcagt ttttacaatt   1860

ttctttgatt cagtgtcgaa aggaattcaa aaatataagc gccataaatt ttcattctgt   1920

tgttgaaaag tatgtaagtg aattttttaa gcgaggtttt ggttcaggta aacgagagtt   1980

tattatgttt ccatatgatt cacgattaga tgataaaaaa ttcttatact cagctcccag   2040

aaataaatcc catattgata cttgtttgca tgcctatatt tttcggcctg aagtgtatca   2100

gttacctatt tgtaaattaa aagaactatt tgaagaaaat agaaaacttc agcagtttag   2160

tccactttca gattatgaag gtcaagaaga agaaatgaat ggtacaaaaa tgaaatttgg   2220

aaaacgaaat aactcaagag gtgaagccat tatatctgga aagcaaagat catctcattc   2280

tttggattat gataaggata gagtcaaaga attgattaat ttaattcagt gtaggaaaaa   2340

gagtgtgggt ggggactcag acacagaaga tatgagaagc aaaactgtct tgaagaggaa   2400

gcttgaggat ctacctgaaa atatgagaaa gctcgccaaa accagtaatt tatctgaaaa   2460

ttgccatctg tatgaagagt ctccacagcc tattggctca cttggacatg atgctgactt   2520

gaggcggcag cagcaggata cctgtaactc cggcattgct gacatccata ggctgtttaa   2580

ttggttatca gaaacactag caaatgcgcg ccattctgat gcatctctga cagacacagt   2640

caacaaagcc ttaggattga gcactgatga tgcctatgaa gagctgaggc aaaaacatga   2700

gtatgagttg aactctaccc cagataagaa agactatgag cagcctactt gtgcaaaagt   2760

tgaaaatgca cagtttaagg gtactcagag cttattacta gaagttgatg caacatctaa   2820

gtattctgtt gctatttcta ccagcgaagt gggcactgac cataagctac atttgaaaga   2880

agatccaaat ttaattagcg tgaataattt tgaagattgc agtttgtgtc ccagtgttcc   2940

cattgaacat ggatttcgta gacaacagtc taagtcaaat aatgttgaag agactgaaat   3000

acattggaaa ctgattccaa ttacagacac actaaagggc accactgagg atgacgtgtt   3060

gacaggtcag gtggaggagc agtgtgtgcc agcagcagag gcagagccgc ctgcagtgag   3120

cgaaaccaca gagaggacag tgttaggaga gtacaatctc ttttctagga agatagaaga   3180

gattttgaag caaaagaatg tttcatatgt cagtacagtt tccacaccta tcttttcaac   3240

acaagagaag atgaaacggc tttccgagtt catatattct aagacttcca aagctggtgt   3300

gcaggagttt gtagatggtt tgcatgagaa gctaaatact attattatta aagcatcagc   3360

caagggtggg aatttgccac cagtcagtcc taacgattct ggtgctaaga tagcatcgaa   3420

tcctctggaa aggcatgtca taccagtttc ctcaagtgac ttcaacaata aacatctcct   3480

tgagccactg tgtagtgatc ctttgaaaga taccaactct gatgagcagc attccacttc   3540

ggctttaact gaagtagaaa tgaaccagcc tcaacatgcc acagagttaa tggtgacttc   3600

tgatcatatt gtacctggtg atatggcccg ggaaccagta gaagaaacaa caaaatcccc   3660

cagtgatgta aacatttctg ctcaaccagc tctttcaaat tttataagcc agttagaacc   3720

tgaagtattt aatagtttgg ttaaaatcat gaaagacgtc cagaaaaata ctgtgaaatt   3780

ttatattcat gaagaagaag agagtgtgct ctgtaaagaa ataaaggaat atcttatcaa   3840

attaggcaat acagaatgtc atcctgaaca gtttttggaa agaagatcaa aattagataa   3900

actattgatt attattcaaa atgaagacat tgcaggtttc attcacaaga tacctggctt   3960

ggtgacttta aagaagctcc cctgtgttag ttttgctggt gttgatagcc tggatgatgt   4020

taaaaatcat acatacaatg aattatttgt atctggaggt tttatcgtat ctgatgaatc   4080

aattctaaac ccagaggttg tcacagttga gaaccttaaa aattttttga cattccttga   4140

ggaacttagt actccagaag gaaaatggca atggaaagtc cactgtaaat ttcagaagaa   4200

actaaaggaa ctaggcagat tgaatgctaa agctctaagt ctgttgacgc ttctgaatgt   4260

ctatcagaag aaacatctgg ttgaaatttt gtcataccac aattgtgatt cacaaactcg   4320

aaatgctcca gaattggatt gccttatcag acttcaggct cagaacatac agcaacgaca   4380

catagtcttt ttaacagaga agaacatcaa gatgctttcc agttatacag ataatggaat   4440

agtggttgca actgctgaag acttcatgca aaactttaaa aatcttgtgg gctatcacaa   4500

ttcaatcaca gaagaaaacc ttccacagct tggtgctaat gagaatcttg agtcgcagtc   4560

agctctttta gaaaacgatg aaaaggatga agaggatatg tctctggatt caggggatga   4620

aatctcacat atagaagtat gcagcaattt tcattcagaa atatgggaga aagagaccaa   4680

aggatcacgt ggaacagatc aaaaaaagaa tactcaaatt gagttgcaat cgtctcctga   4740

tgtgcaaaac agtttattag aagataagac ttaccttgat tctgaagaga gaacttctat   4800

tgatatagta tgctctgaag gagagaacag caattcaaca gaacaagatt catatagtaa   4860

ctttcaggtt tatcatagtc aattaaatat gtcccatcag tttagtcatt ttaatgttct   4920

cactcatcag acatttttgg ggacaccata tgccctttca tcaagtcagt ctcaagaaaa   4980

tgagaattac ttcttatctg cttatactga aagcttggat agagataaat ctccacctcc   5040

cttaagttgg gggaaaagtg attcttccag gccatattca caagagaaat aactgtagta   5100

actttttttt taagagattg ttgtggactt tgtttattaa caatttatat ttcattctct   5160

aaacaaaagg ttcttgttct ttc                                           5183


<210>  1567
<211>  1609
<212>  PRT
<213>  Homo sapiens

<400>  1567


Met Ala Thr Ala Val Glu Thr Glu Ala Cys Gln Pro Thr Asp Ala Ser 
1               5                   10                  15      


Trp Glu Ser Gly Gly Gly Gly Asp Asp Glu Met Lys Gln Ala Leu Pro 
            20                  25                  30          


Glu Leu Glu Ser Ser Gln Gln Asn Gly Gly Gly Gly Gly Leu Asn Ile 
        35                  40                  45              


Ala Glu Pro Ser Gly Gly Ala Gly Arg Glu Glu Asn Ala Gly Ala Glu 
    50                  55                  60                  


Ala Ala Gln Ser Leu Ser His Glu Gln Pro Gln Asp Ser Ser Glu Ala 
65                  70                  75                  80  


Gly Ala Ala Ala Leu Pro Arg Gly Pro Glu Glu Pro Glu Arg Pro Val 
                85                  90                  95      


Arg Arg Ser Phe Gln Ile Pro Arg Lys Ser Arg Glu Lys Lys Ala Leu 
            100                 105                 110         


Phe Gln Pro Leu Thr Pro Gly Ser Arg Glu Phe Glu Asp Val Val Asn 
        115                 120                 125             


Ile Leu His Ser Ser Tyr Leu Glu Pro Thr Ser Val Thr Asn Phe Asn 
    130                 135                 140                 


Tyr Arg Arg Ala Cys Leu Val His Asn Glu Leu Leu Glu Lys Glu Phe 
145                 150                 155                 160 


Thr Glu Lys Arg Arg Glu Leu Lys Phe Asp Gly Arg Leu Asp Lys Glu 
                165                 170                 175     


Leu Ser Glu Ser Tyr Ala Phe Leu Met Val Asp Arg Tyr Gln Val Gln 
            180                 185                 190         


Thr Ile Cys Glu Lys Gly Leu His Val Gly Gln Ser Lys Ile Thr Ile 
        195                 200                 205             


Leu Gly Ser Pro Ser Met Gly Val Tyr Leu Ser Arg Tyr Ala Asp Leu 
    210                 215                 220                 


Leu Gln Ala Asn Pro Leu Asp Thr Gly Ala Met Gly Asp Val Val Ile 
225                 230                 235                 240 


Phe Lys Ile Met Lys Gly Lys Ile Lys Ser Ile Tyr Asp Pro Met Gly 
                245                 250                 255     


Val Lys Ser Leu Glu Ser Met Leu Asn Lys Ser Ala Leu Asp Pro Thr 
            260                 265                 270         


Pro Lys His Glu Cys His Val Ser Lys Asn Ala Asn Arg Ile Thr Ser 
        275                 280                 285             


Leu Leu Ala Tyr Arg Ala Tyr Glu Leu Thr Gln Tyr Tyr Phe Tyr Glu 
    290                 295                 300                 


Tyr Gly Phe Asp Glu Leu Arg Arg Arg Pro Arg His Val Cys Pro Tyr 
305                 310                 315                 320 


Ala Val Val Ser Phe Thr Tyr Lys Asp Asp Ile Gln Thr Pro Lys Phe 
                325                 330                 335     


Val Pro Ser Ser Arg Ser Asn Ser Phe Asn Thr Asp Arg Asn Ile Asp 
            340                 345                 350         


Lys Tyr Asn Tyr Thr Leu Trp Lys Gly Gln Leu Leu Asn Lys Gly Lys 
        355                 360                 365             


Leu Leu Cys Tyr Ile Ser Leu Arg Ser Ala Thr Arg Ala Phe Leu Pro 
    370                 375                 380                 


Ile Lys Leu Pro Glu Lys Leu Asp Val Glu Thr Val Met Ser Ile Asp 
385                 390                 395                 400 


His Leu Lys Gln Lys Ile Pro Pro Ala Leu Phe Tyr Lys Glu Thr Tyr 
                405                 410                 415     


Leu Gly Pro Asn Glu Val Leu Lys Asn Gly Met Tyr Cys Ser Leu Tyr 
            420                 425                 430         


Glu Val Val Glu Lys Thr Arg Ile Gly Ser Asn Met Glu Ser Leu Leu 
        435                 440                 445             


Gln Lys Leu Asp Arg Glu Lys Leu Val Leu Val Lys Pro Leu Gly Asp 
    450                 455                 460                 


Arg Gly Tyr Leu Phe Leu Leu Ser Pro Tyr Gln Met Val Pro Pro Tyr 
465                 470                 475                 480 


Glu Tyr Gln Thr Ala Lys Ser Arg Val Leu His Ala Leu Phe Leu Phe 
                485                 490                 495     


Gln Glu Pro Arg Ser Ile Val Thr Ser Gln Lys Gly Ser Thr Asn Ala 
            500                 505                 510         


Ala Pro Gln Glu Arg His Glu Ser Met Pro Asp Val Leu Lys Ile Ala 
        515                 520                 525             


Gln Phe Leu Gln Phe Ser Leu Ile Gln Cys Arg Lys Glu Phe Lys Asn 
    530                 535                 540                 


Ile Ser Ala Ile Asn Phe His Ser Val Val Glu Lys Tyr Val Ser Glu 
545                 550                 555                 560 


Phe Phe Lys Arg Gly Phe Gly Ser Gly Lys Arg Glu Phe Ile Met Phe 
                565                 570                 575     


Pro Tyr Asp Ser Arg Leu Asp Asp Lys Lys Phe Leu Tyr Ser Ala Pro 
            580                 585                 590         


Arg Asn Lys Ser His Ile Asp Thr Cys Leu His Ala Tyr Ile Phe Arg 
        595                 600                 605             


Pro Glu Val Tyr Gln Leu Pro Ile Cys Lys Leu Lys Glu Leu Phe Glu 
    610                 615                 620                 


Glu Asn Arg Lys Leu Gln Gln Phe Ser Pro Leu Ser Asp Tyr Glu Gly 
625                 630                 635                 640 


Gln Glu Glu Glu Met Asn Gly Thr Lys Met Lys Phe Gly Lys Arg Asn 
                645                 650                 655     


Asn Ser Arg Gly Glu Ala Ile Ile Ser Gly Lys Gln Arg Ser Ser His 
            660                 665                 670         


Ser Leu Asp Tyr Asp Lys Asp Arg Val Lys Glu Leu Ile Asn Leu Ile 
        675                 680                 685             


Gln Cys Arg Lys Lys Ser Val Gly Gly Asp Ser Asp Thr Glu Asp Met 
    690                 695                 700                 


Arg Ser Lys Thr Val Leu Lys Arg Lys Leu Glu Asp Leu Pro Glu Asn 
705                 710                 715                 720 


Met Arg Lys Leu Ala Lys Thr Ser Asn Leu Ser Glu Asn Cys His Leu 
                725                 730                 735     


Tyr Glu Glu Ser Pro Gln Pro Ile Gly Ser Leu Gly His Asp Ala Asp 
            740                 745                 750         


Leu Arg Arg Gln Gln Gln Asp Thr Cys Asn Ser Gly Ile Ala Asp Ile 
        755                 760                 765             


His Arg Leu Phe Asn Trp Leu Ser Glu Thr Leu Ala Asn Ala Arg His 
    770                 775                 780                 


Ser Asp Ala Ser Leu Thr Asp Thr Val Asn Lys Ala Leu Gly Leu Ser 
785                 790                 795                 800 


Thr Asp Asp Ala Tyr Glu Glu Leu Arg Gln Lys His Glu Tyr Glu Leu 
                805                 810                 815     


Asn Ser Thr Pro Asp Lys Lys Asp Tyr Glu Gln Pro Thr Cys Ala Lys 
            820                 825                 830         


Val Glu Asn Ala Gln Phe Lys Gly Thr Gln Ser Leu Leu Leu Glu Val 
        835                 840                 845             


Asp Ala Thr Ser Lys Tyr Ser Val Ala Ile Ser Thr Ser Glu Val Gly 
    850                 855                 860                 


Thr Asp His Lys Leu His Leu Lys Glu Asp Pro Asn Leu Ile Ser Val 
865                 870                 875                 880 


Asn Asn Phe Glu Asp Cys Ser Leu Cys Pro Ser Val Pro Ile Glu His 
                885                 890                 895     


Gly Phe Arg Arg Gln Gln Ser Lys Ser Asn Asn Val Glu Glu Thr Glu 
            900                 905                 910         


Ile His Trp Lys Leu Ile Pro Ile Thr Asp Thr Leu Lys Gly Thr Thr 
        915                 920                 925             


Glu Asp Asp Val Leu Thr Gly Gln Val Glu Glu Gln Cys Val Pro Ala 
    930                 935                 940                 


Ala Glu Ala Glu Pro Pro Ala Val Ser Glu Thr Thr Glu Arg Thr Val 
945                 950                 955                 960 


Leu Gly Glu Tyr Asn Leu Phe Ser Arg Lys Ile Glu Glu Ile Leu Lys 
                965                 970                 975     


Gln Lys Asn Val Ser Tyr Val Ser Thr Val Ser Thr Pro Ile Phe Ser 
            980                 985                 990         


Thr Gln Glu Lys Met Lys Arg Leu  Ser Glu Phe Ile Tyr  Ser Lys Thr 
        995                 1000                 1005             


Ser Lys  Ala Gly Val Gln Glu  Phe Val Asp Gly Leu  His Glu Lys 
    1010                 1015                 1020             


Leu Asn  Thr Ile Ile Ile Lys  Ala Ser Ala Lys Gly  Gly Asn Leu 
    1025                 1030                 1035             


Pro Pro  Val Ser Pro Asn Asp  Ser Gly Ala Lys Ile  Ala Ser Asn 
    1040                 1045                 1050             


Pro Leu  Glu Arg His Val Ile  Pro Val Ser Ser Ser  Asp Phe Asn 
    1055                 1060                 1065             


Asn Lys  His Leu Leu Glu Pro  Leu Cys Ser Asp Pro  Leu Lys Asp 
    1070                 1075                 1080             


Thr Asn  Ser Asp Glu Gln His  Ser Thr Ser Ala Leu  Thr Glu Val 
    1085                 1090                 1095             


Glu Met  Asn Gln Pro Gln His  Ala Thr Glu Leu Met  Val Thr Ser 
    1100                 1105                 1110             


Asp His  Ile Val Pro Gly Asp  Met Ala Arg Glu Pro  Val Glu Glu 
    1115                 1120                 1125             


Thr Thr  Lys Ser Pro Ser Asp  Val Asn Ile Ser Ala  Gln Pro Ala 
    1130                 1135                 1140             


Leu Ser  Asn Phe Ile Ser Gln  Leu Glu Pro Glu Val  Phe Asn Ser 
    1145                 1150                 1155             


Leu Val  Lys Ile Met Lys Asp  Val Gln Lys Asn Thr  Val Lys Phe 
    1160                 1165                 1170             


Tyr Ile  His Glu Glu Glu Glu  Ser Val Leu Cys Lys  Glu Ile Lys 
    1175                 1180                 1185             


Glu Tyr  Leu Ile Lys Leu Gly  Asn Thr Glu Cys His  Pro Glu Gln 
    1190                 1195                 1200             


Phe Leu  Glu Arg Arg Ser Lys  Leu Asp Lys Leu Leu  Ile Ile Ile 
    1205                 1210                 1215             


Gln Asn  Glu Asp Ile Ala Gly  Phe Ile His Lys Ile  Pro Gly Leu 
    1220                 1225                 1230             


Val Thr  Leu Lys Lys Leu Pro  Cys Val Ser Phe Ala  Gly Val Asp 
    1235                 1240                 1245             


Ser Leu  Asp Asp Val Lys Asn  His Thr Tyr Asn Glu  Leu Phe Val 
    1250                 1255                 1260             


Ser Gly  Gly Phe Ile Val Ser  Asp Glu Ser Ile Leu  Asn Pro Glu 
    1265                 1270                 1275             


Val Val  Thr Val Glu Asn Leu  Lys Asn Phe Leu Thr  Phe Leu Glu 
    1280                 1285                 1290             


Glu Leu  Ser Thr Pro Glu Gly  Lys Trp Gln Trp Lys  Val His Cys 
    1295                 1300                 1305             


Lys Phe  Gln Lys Lys Leu Lys  Glu Leu Gly Arg Leu  Asn Ala Lys 
    1310                 1315                 1320             


Ala Leu  Ser Leu Leu Thr Leu  Leu Asn Val Tyr Gln  Lys Lys His 
    1325                 1330                 1335             


Leu Val  Glu Ile Leu Ser Tyr  His Asn Cys Asp Ser  Gln Thr Arg 
    1340                 1345                 1350             


Asn Ala  Pro Glu Leu Asp Cys  Leu Ile Arg Leu Gln  Ala Gln Asn 
    1355                 1360                 1365             


Ile Gln  Gln Arg His Ile Val  Phe Leu Thr Glu Lys  Asn Ile Lys 
    1370                 1375                 1380             


Met Leu  Ser Ser Tyr Thr Asp  Asn Gly Ile Val Val  Ala Thr Ala 
    1385                 1390                 1395             


Glu Asp  Phe Met Gln Asn Phe  Lys Asn Leu Val Gly  Tyr His Asn 
    1400                 1405                 1410             


Ser Ile  Thr Glu Glu Asn Leu  Pro Gln Leu Gly Ala  Asn Glu Asn 
    1415                 1420                 1425             


Leu Glu  Ser Gln Ser Ala Leu  Leu Glu Asn Asp Glu  Lys Asp Glu 
    1430                 1435                 1440             


Glu Asp  Met Ser Leu Asp Ser  Gly Asp Glu Ile Ser  His Ile Glu 
    1445                 1450                 1455             


Val Cys  Ser Asn Phe His Ser  Glu Ile Trp Glu Lys  Glu Thr Lys 
    1460                 1465                 1470             


Gly Ser  Arg Gly Thr Asp Gln  Lys Lys Asn Thr Gln  Ile Glu Leu 
    1475                 1480                 1485             


Gln Ser  Ser Pro Asp Val Gln  Asn Ser Leu Leu Glu  Asp Lys Thr 
    1490                 1495                 1500             


Tyr Leu  Asp Ser Glu Glu Arg  Thr Ser Ile Asp Ile  Val Cys Ser 
    1505                 1510                 1515             


Glu Gly  Glu Asn Ser Asn Ser  Thr Glu Gln Asp Ser  Tyr Ser Asn 
    1520                 1525                 1530             


Phe Gln  Val Tyr His Ser Gln  Leu Asn Met Ser His  Gln Phe Ser 
    1535                 1540                 1545             


His Phe  Asn Val Leu Thr His  Gln Thr Phe Leu Gly  Thr Pro Tyr 
    1550                 1555                 1560             


Ala Leu  Ser Ser Ser Gln Ser  Gln Glu Asn Glu Asn  Tyr Phe Leu 
    1565                 1570                 1575             


Ser Ala  Tyr Thr Glu Ser Leu  Asp Arg Asp Lys Ser  Pro Pro Pro 
    1580                 1585                 1590             


Leu Ser  Trp Gly Lys Ser Asp  Ser Ser Arg Pro Tyr  Ser Gln Glu 
    1595                 1600                 1605             


Lys 
    

<210>  1568
<211>  1262
<212>  DNA
<213>  Homo sapiens

<400>  1568
agttctgatt accagtttcc atcctctcca tttacagaca cactaaaggg caccactgag     60

gatgacgtgt tgacaggtca ggtggaggag cagtgtgtgc cagcagcaga ggcagagccg    120

cctgcagtga gcgaaaccac agagaggaca gtgttaggag agtacaatct cttttctagg    180

aagatagaag agattttgaa gcaaaagaat gtttcatatg tcagtacagt ttccacacct    240

atcttttcaa cacaagagaa gatgaaacgg ctttccgagt tcatatattc taagacttcc    300

aaagctggtg tgcaggagtt tgtagatggt ttgcatgaga agctaaatac tattattatt    360

aaagcatcag ccaagggtgg gaatttgcca ccagtcagtc ctaacgattc tggtgctaag    420

atagcatcga atcctctgga aaggcatgtc ataccagttt cctcaagtga cttcaacaat    480

aaacatctcc ttgagccact gtgtagtgat cctttgaaag ataccaactc tgatgagcag    540

cattccactt cggctttaac tgaagtagaa atgaaccagc ctcaacatgc cacagagtta    600

atggtgactt ctgatcatat tgtacctggt gatatggccc gggaaccagt agaagaaaca    660

acaaaatccc ccagtgatgt aaacatttct gctcaaccag ctctttcaaa ttttataagc    720

cagttagaac ctgaagtatt taatagtttg gttaaaatca tgaaagacgt ccagaaaaat    780

actgtgaaat tttatattca tgaagaagaa gagagtgtgc tctgtaaaga aataaaggta    840

actaaaccag aaggtaatag taatgctgta caaacttctc ttgttggtgt gacctctata    900

aaatggaagt tttttgtatt taaatgtttt gtgtttaaat gttagtgagc cgagatcacg    960

ccagtgcact ccagcctggg cgacagagca agactccatc tcaaaaaaaa aaaaaaaaac   1020

aaaaaaacac agacacacac acacacgcct ttctgtgtgt ctgtatgttt agacatagat   1080

acgtaagttt gttaccagta ggtaggtaaa tggtaacaca ttggagcaat tacattagtg   1140

gtataatagt aaaattaatc ataaattatg ggattttaat tcctcaaggg aatgcctagg   1200

attttgaaat aaatgcctgc tctcatttat ggagtttact taccatgact ggaatttcat   1260

ta                                                                  1262


<210>  1569
<211>  56
<212>  PRT
<213>  Homo sapiens

<400>  1569


Met Leu Val Ser Arg Asp His Ala Ser Ala Leu Gln Pro Gly Arg Gln 
1               5                   10                  15      


Ser Lys Thr Pro Ser Gln Lys Lys Lys Lys Lys Gln Lys Asn Thr Asp 
            20                  25                  30          


Thr His Thr His Ala Phe Leu Cys Val Cys Met Phe Arg His Arg Tyr 
        35                  40                  45              


Val Ser Leu Leu Pro Val Gly Arg 
    50                  55      

<210>  1570
<211>  403
<212>  DNA
<213>  Homo sapiens

<400>  1570
gggaaaacaa gttttaaatg acatctcttt tttccaccag atgttgctgt agcattacat     60

ttatctgctg tgttaaattg ttactaatat gcaattatgt aaaataactt tttaactgaa    120

aatcttaagt gtagagatag cttactagct aatggttcaa ttgtaaattc tatttgccat    180

ctttgagcta agctaaccgt acttaagagt ttgttttcct ttccaaagaa aggaatgtag    240

agagtaatat gttggtaata tgatttatat tagtgaagag tattatgaat ggagtttcta    300

tttacttgtt attaaacaag ttcaaatgat tttttttttt tcttttagtg attagctttt    360

tcttactgct tcaaatttgg taaaagtgtt ctatgagata tta                      403


<210>  1571
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  1571


Met Ile Tyr Ile Ser Glu Glu Tyr Tyr Glu Trp Ser Phe Tyr Leu Leu 
1               5                   10                  15      


Val Ile Lys Gln Val Gln Met Ile Phe Phe Phe Ser Phe Ser Asp 
            20                  25                  30      

<210>  1572
<211>  226
<212>  DNA
<213>  Homo sapiens

<400>  1572
agacactatt taataagggt caagaatgta acagtcaaaa caggtcacta ctgaaaacat     60

aatgttccac ttgtacatac tcctaaaggt aacagatgca gcgaaccgtt atctttttta    120

tacatgatta ttagacttta aaagacatgt caaatgacag agccattcat ccattcattt    180

gttcttcaca gtaagatctt tttttaaaat cacttttctt cattct                   226


<210>  1573
<211>  4144
<212>  DNA
<213>  Homo sapiens

<400>  1573
gtgcttgcgc gtgtgtgtgt gtgtgtattc agtacgctag tggtgcagct ctgacgtaaa     60

aaaatgtttt aaaccctcct ctgagcacaa atgctcaaga gcctggcact ggacagggag    120

catcctgaag ggcattgtca cctgaagcag aagagctgtc agatctttcc cttcagcact    180

taaatcattg tcacgcaatg gctttcatct tgggagattc atcctctgca ttttggaact    240

gagccttcct agtgttctga gagttttctg ctgtctgttc agcttagcac gctaagaagc    300

tggagaggta cccagcagcc tggttgcatt ctccgtcttg gaaaagtatt taactgcttt    360

gagaaatcat ggaatcgttt ctggccacat tgtgagattg tattgaattt tctttttaag    420

tttttaaatt tttatatgca aatgctggaa agcttggaga cagtctattt caaagaaggc    480

tgttgatttc tgagactggc aggggcataa aatgacatga gagtgtctca gcaggattcc    540

aaattcacga aagatttttc caggcaccta ctatgttcag aacggggatg cagaaatatc    600

ctggagaatc tgaagttctg ccttaaccct cgaaactttg aaagcaatgg ctgaaaagga    660

aagatgaata cctagaggct ccctctggaa atgattgagg tttgccacca caattggcta    720

ctttggcttt gcccatcaaa atttggtatc ttcatgtgct gtctagcatc tactacaggt    780

cagatggagc ttaggaggac aagggagcct agtaataaac gggtcaaacc cctttcccga    840

gtcacgtcgc tagcaaacct catcccgccc gtgaaggcca cgccattaaa gcgcttcagt    900

caaaccctgc agcgctccat tagcttccgc agtgagagcc gccctgacat cctcgccccc    960

cgaccctggt ccagaaatgc cgccccctcg agcacgaaac ggagagatag caagctgtgg   1020

agtgagacct tcgatgtgtg cgtcaatcag atgcttacat ccaaggaaat caaacgtcag   1080

gaggcgatct ttgagctttc ccaaggagaa gaagacttga tagaagactt gaaattagca   1140

aaaaaggcct atcatgaccc catgctgaaa ctctccataa tgacagaaca agagttgaat   1200

caaatttttg gaacactgga ctctctaatt cctctacatg aagagctcct tagtcagctt   1260

cgagatgtta ggaagcctga tggctcgact gaacatgttg gtcccatcct cgtgggctgg   1320

ctcccttgcc tcagctccta tgatagctac tgcagcaatc aagtagccgc caaagctctg   1380

ctggaccaca aaaagcaaga tcaccgagtc caggatttcc tacagcgatg tttagaatcc   1440

ccctttagcc gcaaactaga tctctggaat ttcctcgata ttccaagaag ccgcctggta   1500

aaataccctc tgcttctccg agaaatcttg aggcacacac caaatgataa tccagatcag   1560

cagcacttgg aagaagctat aaatatcatt cagggaattg tggcagaaat caacaccaag   1620

actggtgaat ctgaatgccg ctattataaa gagcggcttc tttacttgga agaaggccag   1680

aaagactccc tgatcgacag ctctcgagtc ttgtgttgtc atggtgaact gaagaacaat   1740

cggggcgtga aactgcatgt tttcctgttc caagaagtgc ttgtgatcac tcgagccgtc   1800

acccacaatg agcagctttg ctaccagctg taccgtcagc caatccccgt gaaagacctc   1860

ctgctggaag acctccagga tggagaagtg aggctgggtg gctccctgcg aggggcattc   1920

agcaacaatg agagaattaa aaacttcttc agagtcagtt tcaaaaatgg atcccaaagt   1980

cagacccact cgctacaagc caatgacact ttcaacaaac agcagtggct taactgtatt   2040

cgtcaagcca aagaaacagt tttgtgtgct gccgggcaag ctggggtgct tgactccgag   2100

ggatcgttcc taaatcccac caccgggagc agagagctac agggagaaac aaaacttgag   2160

cagatggacc aatcggacag tgagtcagac tgtagtatgg acacgagtga ggtcagcctc   2220

gactgtgagc gcatggaaca gacagactct tcctgtggaa acagcaggca cggtgaaagt   2280

aacgtctgac agaagcatgt gcacttcggg aagcaggcct gcatcttacc tgtacagtat   2340

ttgcattcca cagatggaac ggtttggaga agcacttttt catacttttg tgaaagtata   2400

catgttggcc cagtctctcg tatctgtacc tttgtcccta gtactgtaac tgccaatctg   2460

tctgtgtaag ctggaatctg tggcaactat taccctgtgt tgtatttccc aagtgtctgg   2520

atggatggag aggtactcaa acaagttact ttcagttgtc ctgctggatt ttaaaaaaat   2580

agaaaaagaa tctcaaaact actgttttac atagattgtt tgaagagtcc ttcctcttgt   2640

gcttctgtac cactttccca gctcttagat gtggtagcta aaggcacgga atttagacgg   2700

ccttgtaaat agggcatgag gaactcatct gtgtattggg atggtattag agagagaatc   2760

aggaaagacc aactcatgaa gtgaacttgg tttgatctta ctcaactaga aagcttgaaa   2820

acatccctgg ggattctgaa ggcttaattt tgcaaaggag gatgcattgt ctgaactttg   2880

caacttcatc cagtgcaagt ttgatgcaag aatgtattag gacataaaat agaggctgac   2940

cttaaaaggg ccaggacaga agcggctgcc agctctgaat ctttaactga aatgcacatg   3000

gcaccaggag gtgtctctca tagttggttg ctagcctaaa acatcagaat agaacccaaa   3060

gggcttagga aggcctgcca ggataacaag aaggccctgt attcattgtg tttcatctgc   3120

ctaggcctac tcattatttt agagaatgaa tgaagcaaca aggaagagag accatgactc   3180

tatcgatgac actgtttata gaaacacagg agaggaagaa tttggaatga aaagcacttc   3240

gtcagaacct tctgtgggag ccattgagag aaaagcatgg tccagtgcct tctgagaaag   3300

gccagagctt tgggctttcc tgctctgctt ttgggtcgtc aatttgccat ctctggttct   3360

gtgctataat cagaattgta attatgttct ccagaggcca atttcattaa ctctgattaa   3420

ttagaatcag ctagccagat tagtaacctc tttgtccagc cttgatttac agtgcagggt   3480

aaagtgcaga ccttaaaaac agctaagtac ctagaagagc tccctgcaag tgtaaatatt   3540

aaggatgacc tgtgcaaaat tatacccaca ccagcactag tggtaattat tctaaattat   3600

tgccaaaaag ttttttttaa tctgtctttc aagtttacag aaaagaaagc agtaaatgca   3660

ttgatgtcat tttattatgt acatatatca tgtgcattca agctgtgtga caagatatat   3720

caatataaaa acaaggtata tactttatta ttttttgaaa acaaggatat tgtgatcaat   3780

tttaccctgt aaaacatatt tctgtattta taggtcttaa acatgatgaa ttttttctat   3840

tacaagttta tttaaaactg ctttctcaag tcgttattga tacagcaagt gaacctgctg   3900

cagacagaag cagaggaaag ccaagaacag cctttattgg tgaagaaaag aatgaatgat   3960

tctttgtagg cgccatcagc cacttttaga agccatcagc cagtgtgttg ggaaaagagg   4020

tttgtcaagt gttggcctat gggaaggtgg tcaatgaatg ttttgatgaa atgaatgttt   4080

ttgtataatg gccttaaact tttctggaag tatttcaaat aaattacatt attaagtcat   4140

cctc                                                                4144


<210>  1574
<211>  532
<212>  PRT
<213>  Homo sapiens

<400>  1574


Met Ile Glu Val Cys His His Asn Trp Leu Leu Trp Leu Cys Pro Ser 
1               5                   10                  15      


Lys Phe Gly Ile Phe Met Cys Cys Leu Ala Ser Thr Thr Gly Gln Met 
            20                  25                  30          


Glu Leu Arg Arg Thr Arg Glu Pro Ser Asn Lys Arg Val Lys Pro Leu 
        35                  40                  45              


Ser Arg Val Thr Ser Leu Ala Asn Leu Ile Pro Pro Val Lys Ala Thr 
    50                  55                  60                  


Pro Leu Lys Arg Phe Ser Gln Thr Leu Gln Arg Ser Ile Ser Phe Arg 
65                  70                  75                  80  


Ser Glu Ser Arg Pro Asp Ile Leu Ala Pro Arg Pro Trp Ser Arg Asn 
                85                  90                  95      


Ala Ala Pro Ser Ser Thr Lys Arg Arg Asp Ser Lys Leu Trp Ser Glu 
            100                 105                 110         


Thr Phe Asp Val Cys Val Asn Gln Met Leu Thr Ser Lys Glu Ile Lys 
        115                 120                 125             


Arg Gln Glu Ala Ile Phe Glu Leu Ser Gln Gly Glu Glu Asp Leu Ile 
    130                 135                 140                 


Glu Asp Leu Lys Leu Ala Lys Lys Ala Tyr His Asp Pro Met Leu Lys 
145                 150                 155                 160 


Leu Ser Ile Met Thr Glu Gln Glu Leu Asn Gln Ile Phe Gly Thr Leu 
                165                 170                 175     


Asp Ser Leu Ile Pro Leu His Glu Glu Leu Leu Ser Gln Leu Arg Asp 
            180                 185                 190         


Val Arg Lys Pro Asp Gly Ser Thr Glu His Val Gly Pro Ile Leu Val 
        195                 200                 205             


Gly Trp Leu Pro Cys Leu Ser Ser Tyr Asp Ser Tyr Cys Ser Asn Gln 
    210                 215                 220                 


Val Ala Ala Lys Ala Leu Leu Asp His Lys Lys Gln Asp His Arg Val 
225                 230                 235                 240 


Gln Asp Phe Leu Gln Arg Cys Leu Glu Ser Pro Phe Ser Arg Lys Leu 
                245                 250                 255     


Asp Leu Trp Asn Phe Leu Asp Ile Pro Arg Ser Arg Leu Val Lys Tyr 
            260                 265                 270         


Pro Leu Leu Leu Arg Glu Ile Leu Arg His Thr Pro Asn Asp Asn Pro 
        275                 280                 285             


Asp Gln Gln His Leu Glu Glu Ala Ile Asn Ile Ile Gln Gly Ile Val 
    290                 295                 300                 


Ala Glu Ile Asn Thr Lys Thr Gly Glu Ser Glu Cys Arg Tyr Tyr Lys 
305                 310                 315                 320 


Glu Arg Leu Leu Tyr Leu Glu Glu Gly Gln Lys Asp Ser Leu Ile Asp 
                325                 330                 335     


Ser Ser Arg Val Leu Cys Cys His Gly Glu Leu Lys Asn Asn Arg Gly 
            340                 345                 350         


Val Lys Leu His Val Phe Leu Phe Gln Glu Val Leu Val Ile Thr Arg 
        355                 360                 365             


Ala Val Thr His Asn Glu Gln Leu Cys Tyr Gln Leu Tyr Arg Gln Pro 
    370                 375                 380                 


Ile Pro Val Lys Asp Leu Leu Leu Glu Asp Leu Gln Asp Gly Glu Val 
385                 390                 395                 400 


Arg Leu Gly Gly Ser Leu Arg Gly Ala Phe Ser Asn Asn Glu Arg Ile 
                405                 410                 415     


Lys Asn Phe Phe Arg Val Ser Phe Lys Asn Gly Ser Gln Ser Gln Thr 
            420                 425                 430         


His Ser Leu Gln Ala Asn Asp Thr Phe Asn Lys Gln Gln Trp Leu Asn 
        435                 440                 445             


Cys Ile Arg Gln Ala Lys Glu Thr Val Leu Cys Ala Ala Gly Gln Ala 
    450                 455                 460                 


Gly Val Leu Asp Ser Glu Gly Ser Phe Leu Asn Pro Thr Thr Gly Ser 
465                 470                 475                 480 


Arg Glu Leu Gln Gly Glu Thr Lys Leu Glu Gln Met Asp Gln Ser Asp 
                485                 490                 495     


Ser Glu Ser Asp Cys Ser Met Asp Thr Ser Glu Val Ser Leu Asp Cys 
            500                 505                 510         


Glu Arg Met Glu Gln Thr Asp Ser Ser Cys Gly Asn Ser Arg His Gly 
        515                 520                 525             


Glu Ser Asn Val 
    530         

<210>  1575
<211>  2611
<212>  DNA
<213>  Homo sapiens

<400>  1575
cccagtcgag tcctgcccgg ctagaagccg gctgtcggtc tccgtgtcgc cgccgccgcc     60

cggcatcgtg gagctggggc ccccttttgc ctgggagttt tgtagtcgcc tagggtcagc    120

ggtgacatcc caaagggcag gcccggcagc cgccatggtg gccaaggatt accccttcta    180

cctcacggtc aagagagcga actgcagcct ggagctaccc ccggccagcg gtccggccaa    240

ggacgctgag gagcctagta ataaacgggt caaacccctt tcccgagtca cgtcgctagc    300

aaacctcatc ccgccctgaa agacctcctg ctggaagacc tccaggatgg agaagtgagg    360

ctgggtggct ccctgcgagg ggcattcagc aacaatgaga gaattaaaaa cttcttcaga    420

gtcagtttca aaaatggatc ccaaagtcag acccactcgc tacaagccaa tgacactttc    480

aacaaacagc agtggcttaa ctgtattcgt caagccaaag aaacagtttt gtgtgctgcc    540

gggcaagctg gggtgcttga ctccgaggga tcgttcctaa atcccaccac cgggagcaga    600

gagctacagg gagaaacaaa acttgagcag atggaccaat cggacagtga gtcagactgt    660

agtatggaca cgagtgaggt cagcctcgac tgtgagcgca tggaacagac agactcttcc    720

tgtggaaaca gcaggcacgg tgaaagtaac gtctgacaga agcatgtgca cttcgggaag    780

caggcctgca tcttacctgt acagtatttg cattccacag atggaacggt ttggagaagc    840

actttttcat acttttgtga aagtatacat gttggcccag tctctcgtat ctgtaccttt    900

gtccctagta ctgtaactgc caatctgtct gtgtaagctg gaatctgtgg caactattac    960

cctgtgttgt atttcccaag tgtctggatg gatggagagg tactcaaaca agttactttc   1020

agttgtcctg ctggatttta aaaaaataga aaaagaatct caaaactact gttttacata   1080

gattgtttga agagtccttc ctcttgtgct tctgtaccac tttcccagct cttagatgtg   1140

gtagctaaag gcacggaatt tagacggcct tgtaaatagg gcatgaggaa ctcatctgtg   1200

tattgggatg gtattagaga gagaatcagg aaagaccaac tcatgaagtg aacttggttt   1260

gatcttactc aactagaaag cttgaaaaca tccctgggga ttctgaaggc ttaattttgc   1320

aaaggaggat gcattgtctg aactttgcaa cttcatccag tgcaagtttg atgcaagaat   1380

gtattaggac ataaaataga ggctgacctt aaaagggcca ggacagaagc ggctgccagc   1440

tctgaatctt taactgaaat gcacatggca ccaggaggtg tctctcatag ttggttgcta   1500

gcctaaaaca tcagaataga acccaaaggg cttaggaagg cctgccagga taacaagaag   1560

gccctgtatt cattgtgttt catctgccta ggcctactca ttattttaga gaatgaatga   1620

agcaacaagg aagagagacc atgactctat cgatgacact gtttatagaa acacaggaga   1680

ggaagaattt ggaatgaaaa gcacttcgtc agaaccttct gtgggagcca ttgagagaaa   1740

agcatggtcc agtgccttct gagaaaggcc agagctttgg gctttcctgc tctgcttttg   1800

ggtcgtcaat ttgccatctc tggttctgtg ctataatcag aattgtaatt atgttctcca   1860

gaggccaatt tcattaactc tgattaatta gaatcagcta gccagattag taacctcttt   1920

gtccagcctt gatttacagt gcagggtaaa gtgcagacct taaaaacagc taagtaccta   1980

gaagagctcc ctgcaagtgt aaatattaag gatgacctgt gcaaaattat acccacacca   2040

gcactagtgg taattattct aaattattgc caaaaagttt tttttaatct gtctttcaag   2100

tttacagaaa agaaagcagt aaatgcattg atgtcatttt attatgtaca tatatcatgt   2160

gcattcaagc tgtgtgacaa gatatatcaa tataaaaaca aggtatatac tttattattt   2220

tttgaaaaca aggatattgt gatcaatttt accctgtaaa acatatttct gtatttatag   2280

gtcttaaaca tgatgaattt tttctattac aagtttattt aaaactgctt tctcaagtcg   2340

ttattgatac agcaagtgaa cctgctgcag acagaagcag aggaaagcca agaacagcct   2400

ttattggtga agaaaagaat gaatgattct ttgtaggcgc catcagccac ttttagaagc   2460

catcagccag tgtgttggga aaagaggttt gtcaagtgtt ggcctatggg aaggtggtca   2520

atgaatgttt tgatgaaatg aatgtttttg tataatggcc ttaaactttt ctggaagtat   2580

ttcaaataaa ttacattatt aagtcatcct c                                  2611


<210>  1576
<211>  61
<212>  PRT
<213>  Homo sapiens

<400>  1576


Met Arg Glu Leu Lys Thr Ser Ser Glu Ser Val Ser Lys Met Asp Pro 
1               5                   10                  15      


Lys Val Arg Pro Thr Arg Tyr Lys Pro Met Thr Leu Ser Thr Asn Ser 
            20                  25                  30          


Ser Gly Leu Thr Val Phe Val Lys Pro Lys Lys Gln Phe Cys Val Leu 
        35                  40                  45              


Pro Gly Lys Leu Gly Cys Leu Thr Pro Arg Asp Arg Ser 
    50                  55                  60      

<210>  1577
<211>  3528
<212>  DNA
<213>  Homo sapiens

<400>  1577
cactcggctc cggagcccag tcgagtcctg cccggctaga agccggctgt cggtctccgt     60

gtcgccgccg ccgcccggca tcgtggagct ggggccccct tttgcctggg agttttgtag    120

tcgcctaggg tcagcggtga catcccaaag ggcaggcccg gcagccgcca tggtggccaa    180

ggattacccc ttctacctca cggtcaagag agcgaactgc agcctggagc tacccccggc    240

cagcggtccg gccaaggacg ctgaggagcc tagtaataaa cgggtcaaac ccctttcccg    300

agtcacgtcg ctagcaaacc tcatcccgcc cgtgaaggcc acgccattaa agcgcttcag    360

tcaaaccctg cagcgctcca ttagcttccg cagtgagagc cgccctgaca tcctcgcccc    420

ccgaccctgg tccagaaatg ccgccccctc gagcacgaaa cggagagata gcaagctgtg    480

gagtgagacc ttcgatgtgt gcgtcaatca gatgcttaca tccaaggaaa tcaaacgtca    540

ggaggcgatc tttgagcttt cccaaggaga agaagacttg atagaagact tgaaattagc    600

aaaaaaggcc tatcatgacc ccatgctgaa actctccata atgacagaac aagagttgaa    660

tcaaattttt ggaacactgg actctctaat tcctctacat gaagctccct tgcctcagct    720

cctatgatag ctactgcagc aatcaagtag ccgccaaagc tctgctggac cacaaaaagc    780

aagatcaccg agtccaggat ttcctacagc gatgtttaga atcccccttt agccgcaaac    840

tagatctctg gaatttcctc gatattccaa gaagccgcct ggtaaaatac cctctgcttc    900

tccgagaaat cttgaggcac acaccaaatg ataatccaga tcagcagcac ttggaagaag    960

ctataaatat cattcaggga attgtggcag aaatcaacac caagactggt gaatctgaat   1020

gccgctatta taaagagcgg cttctttact tggaagaagg ccagaaagac tccctgatcg   1080

acagctctcg agtcttgtgt tgtcatggtg aactgaagaa caatcggggc gtgaaactgc   1140

atgttttcct gttccaagaa gtgcttgtga tcactcgagc cgtcacccac aatgagcagc   1200

tttgctacca gctgtaccgt cagccaatcc ccgtgaaaga cctcctgctg gaagacctcc   1260

aggatggaga agtgaggctg ggtggctccc tgcgaggggc attcagcaac aatgagagaa   1320

ttaaaaactt cttcagagtc agtttcaaaa atggatccca aagtcagacc cactcgctac   1380

aagccaatga cactttcaac aaacagcagt ggcttaactg tattcgtcaa gccaaagaaa   1440

cagttttgtg tgctgccggg caagctgggg tgcttgactc cgagggatcg ttcctaaatc   1500

ccaccaccgg gagcagagag ctacagggag aaacaaaact tgagcagatg gaccaatcgg   1560

acagtgagtc agactgtagt atggacacga gtgaggtcag cctcgactgt gagcgcatgg   1620

aacagacaga ctcttcctgt ggaaacagca ggcacggtga aagtaacgtc tgacagaagc   1680

atgtgcactt cgggaagcag gcctgcatct tacctgtaca gtatttgcat tccacagatg   1740

gaacggtttg gagaagcact ttttcatact tttgtgaaag tatacatgtt ggcccagtct   1800

ctcgtatctg tacctttgtc cctagtactg taactgccaa tctgtctgtg taagctggaa   1860

tctgtggcaa ctattaccct gtgttgtatt tcccaagtgt ctggatggat ggagaggtac   1920

tcaaacaagt tactttcagt tgtcctgctg gattttaaaa aaatagaaaa agaatctcaa   1980

aactactgtt ttacatagat tgtttgaaga gtccttcctc ttgtgcttct gtaccacttt   2040

cccagctctt agatgtggta gctaaaggca cggaatttag acggccttgt aaatagggca   2100

tgaggaactc atctgtgtat tgggatggta ttagagagag aatcaggaaa gaccaactca   2160

tgaagtgaac ttggtttgat cttactcaac tagaaagctt gaaaacatcc ctggggattc   2220

tgaaggctta attttgcaaa ggaggatgca ttgtctgaac tttgcaactt catccagtgc   2280

aagtttgatg caagaatgta ttaggacata aaatagaggc tgaccttaaa agggccagga   2340

cagaagcggc tgccagctct gaatctttaa ctgaaatgca catggcacca ggaggtgtct   2400

ctcatagttg gttgctagcc taaaacatca gaatagaacc caaagggctt aggaaggcct   2460

gccaggataa caagaaggcc ctgtattcat tgtgtttcat ctgcctaggc ctactcatta   2520

ttttagagaa tgaatgaagc aacaaggaag agagaccatg actctatcga tgacactgtt   2580

tatagaaaca caggagagga agaatttgga atgaaaagca cttcgtcaga accttctgtg   2640

ggagccattg agagaaaagc atggtccagt gccttctgag aaaggccaga gctttgggct   2700

ttcctgctct gcttttgggt cgtcaatttg ccatctctgg ttctgtgcta taatcagaat   2760

tgtaattatg ttctccagag gccaatttca ttaactctga ttaattagaa tcagctagcc   2820

agattagtaa cctctttgtc cagccttgat ttacagtgca gggtaaagtg cagaccttaa   2880

aaacagctaa gtacctagaa gagctccctg caagtgtaaa tattaaggat gacctgtgca   2940

aaattatacc cacaccagca ctagtggtaa ttattctaaa ttattgccaa aaagtttttt   3000

ttaatctgtc tttcaagttt acagaaaaga aagcagtaaa tgcattgatg tcattttatt   3060

atgtacatat atcatgtgca ttcaagctgt gtgacaagat atatcaatat aaaaacaagg   3120

tatatacttt attatttttt gaaaacaagg atattgtgat caattttacc ctgtaaaaca   3180

tatttctgta tttataggtc ttaaacatga tgaatttttt ctattacaag tttatttaaa   3240

actgctttct caagtcgtta ttgatacagc aagtgaacct gctgcagaca gaagcagagg   3300

aaagccaaga acagccttta ttggtgaaga aaagaatgaa tgattctttg taggcgccat   3360

cagccacttt tagaagccat cagccagtgt gttgggaaaa gaggtttgtc aagtgttggc   3420

ctatgggaag gtggtcaatg aatgttttga tgaaatgaat gtttttgtat aatggcctta   3480

aacttttctg gaagtatttc aaataaatta cattattaag tcatcctc                3528


<210>  1578
<211>  324
<212>  PRT
<213>  Homo sapiens

<400>  1578


Met Lys Leu Pro Cys Leu Ser Ser Tyr Asp Ser Tyr Cys Ser Asn Gln 
1               5                   10                  15      


Val Ala Ala Lys Ala Leu Leu Asp His Lys Lys Gln Asp His Arg Val 
            20                  25                  30          


Gln Asp Phe Leu Gln Arg Cys Leu Glu Ser Pro Phe Ser Arg Lys Leu 
        35                  40                  45              


Asp Leu Trp Asn Phe Leu Asp Ile Pro Arg Ser Arg Leu Val Lys Tyr 
    50                  55                  60                  


Pro Leu Leu Leu Arg Glu Ile Leu Arg His Thr Pro Asn Asp Asn Pro 
65                  70                  75                  80  


Asp Gln Gln His Leu Glu Glu Ala Ile Asn Ile Ile Gln Gly Ile Val 
                85                  90                  95      


Ala Glu Ile Asn Thr Lys Thr Gly Glu Ser Glu Cys Arg Tyr Tyr Lys 
            100                 105                 110         


Glu Arg Leu Leu Tyr Leu Glu Glu Gly Gln Lys Asp Ser Leu Ile Asp 
        115                 120                 125             


Ser Ser Arg Val Leu Cys Cys His Gly Glu Leu Lys Asn Asn Arg Gly 
    130                 135                 140                 


Val Lys Leu His Val Phe Leu Phe Gln Glu Val Leu Val Ile Thr Arg 
145                 150                 155                 160 


Ala Val Thr His Asn Glu Gln Leu Cys Tyr Gln Leu Tyr Arg Gln Pro 
                165                 170                 175     


Ile Pro Val Lys Asp Leu Leu Leu Glu Asp Leu Gln Asp Gly Glu Val 
            180                 185                 190         


Arg Leu Gly Gly Ser Leu Arg Gly Ala Phe Ser Asn Asn Glu Arg Ile 
        195                 200                 205             


Lys Asn Phe Phe Arg Val Ser Phe Lys Asn Gly Ser Gln Ser Gln Thr 
    210                 215                 220                 


His Ser Leu Gln Ala Asn Asp Thr Phe Asn Lys Gln Gln Trp Leu Asn 
225                 230                 235                 240 


Cys Ile Arg Gln Ala Lys Glu Thr Val Leu Cys Ala Ala Gly Gln Ala 
                245                 250                 255     


Gly Val Leu Asp Ser Glu Gly Ser Phe Leu Asn Pro Thr Thr Gly Ser 
            260                 265                 270         


Arg Glu Leu Gln Gly Glu Thr Lys Leu Glu Gln Met Asp Gln Ser Asp 
        275                 280                 285             


Ser Glu Ser Asp Cys Ser Met Asp Thr Ser Glu Val Ser Leu Asp Cys 
    290                 295                 300                 


Glu Arg Met Glu Gln Thr Asp Ser Ser Cys Gly Asn Ser Arg His Gly 
305                 310                 315                 320 


Glu Ser Asn Val 
                

<210>  1579
<211>  3605
<212>  DNA
<213>  Homo sapiens

<400>  1579
cactcggctc cggagcccag tcgagtcctg cccggctaga agccggctgt cggtctccgt     60

gtcgccgccg ccgcccggca tcgtggagct ggggccccct tttgcctggg agttttgtag    120

tcgcctaggg tcagcggtga catcccaaag ggcaggcccg gcagccgcca tggtggccaa    180

ggattacccc ttctacctca cggtcaagag agcgaactgc agcctggagc tacccccggc    240

cagcggtccg gccaaggacg ctgaggagcc tagtaataaa cgggtcaaac ccctttcccg    300

agtcacgtcg ctagcaaacc tcatcccgcc cgtgaaggcc acgccattaa agcgcttcag    360

tcaaaccctg cagcgctcca ttagcttccg cagtgagagc cgccctgaca tcctcgcccc    420

ccgaccctgg tccagaaatg ccgccccctc gagcacgaaa cggagagata gcaagctgtg    480

gagtgagacc ttcgatgtgt gcgtcaatca gatgcttaca tccaaggaaa tcaaacgtca    540

ggaggcgatc tttgagcttt cccaaggaga agaagacttg atagaagact tgaaattagc    600

aaaaaaggcc tatcatgacc ccatgctgaa actctccata atgacagaac aagagttgaa    660

tcaaattttt ggaacactgg actctctaat tcctctacat gaagagctcc ttagtcagct    720

tcgagatgtt aggaagcctg atggctcgac tgaacatgtt ggtcccatcc tcgtgggctg    780

gctcccttgc ctcagctcct atgatagcta ctgcagcaat caagtagccg ccaaagctct    840

gctggaccac aaaaagcaag atcaccgagt ccaggatttc ctacagcgat gtttagaatc    900

cccctttagc cgcaaactag atctctggaa tttcctcgat attccaagaa gccgcctggt    960

aaaataccct ctgcttctcc gagaaatctt gaggcacaca ccaaatgata atccagatca   1020

gcagcacttg gaagaagcta taaatatcat tcagggaatt gtggcagaaa tcaacaccaa   1080

gactggtgaa tctgaatgcc gctattataa agagcggctt ctttacttgg aagaaggcca   1140

gaaagactcc ctgatcgaca gctctcgagt cttgtgttgt catggtgaac tgaagaacaa   1200

tcggggcgtg aaactgcatg ttttcctgtt ccaagaagtg cttgtgatca ctcgagccgt   1260

cacccacaat gagcagcttt gctaccagct gtaccgtcag ccaatccccg tgaaagacct   1320

cctgctggaa gacctccagg atggagaagt gaggctgggt ggctccctgc gaggggcatt   1380

cagcaacaat gagagaatta aaaacttctt cagagtcagt ttcaaaaatg gatcccaaag   1440

tcagacccac tcgctacaag ccaatgacac tttcaacaaa cagcagtggc ttaactgtat   1500

tcgtcaagcc aaagaaacag ttttgtgtgc tgccgggcaa gctggggtgc ttgactccga   1560

gggatcgttc ctaaatccca ccaccgggag cagagagcta cagggagaaa caaaacttga   1620

gcagatggac caatcggaca gtgagtcaga ctgtagtatg gacacgagtg aggtcagcct   1680

cgactgtgag cgcatggaac agacagactc ttcctgtgga aacagcaggc acggtgaaag   1740

taacgtctga cagaagcatg tgcacttcgg gaagcaggcc tgcatcttac ctgtacagta   1800

tttgcattcc acagatggaa cggtttggag aagcactttt tcatactttt gtgaaagtat   1860

acatgttggc ccagtctctc gtatctgtac ctttgtccct agtactgtaa ctgccaatct   1920

gtctgtgtaa gctggaatct gtggcaacta ttaccctgtg ttgtatttcc caagtgtctg   1980

gatggatgga gaggtactca aacaagttac tttcagttgt cctgctggat tttaaaaaaa   2040

tagaaaaaga atctcaaaac tactgtttta catagattgt ttgaagagtc cttcctcttg   2100

tgcttctgta ccactttccc agctcttaga tgtggtagct aaaggcacgg aatttagacg   2160

gccttgtaaa tagggcatga ggaactcatc tgtgtattgg gatggtatta gagagagaat   2220

caggaaagac caactcatga agtgaacttg gtttgatctt actcaactag aaagcttgaa   2280

aacatccctg gggattctga aggcttaatt ttgcaaagga ggatgcattg tctgaacttt   2340

gcaacttcat ccagtgcaag tttgatgcaa gaatgtatta ggacataaaa tagaggctga   2400

ccttaaaagg gccaggacag aagcggctgc cagctctgaa tctttaactg aaatgcacat   2460

ggcaccagga ggtgtctctc atagttggtt gctagcctaa aacatcagaa tagaacccaa   2520

agggcttagg aaggcctgcc aggataacaa gaaggccctg tattcattgt gtttcatctg   2580

cctaggccta ctcattattt tagagaatga atgaagcaac aaggaagaga gaccatgact   2640

ctatcgatga cactgtttat agaaacacag gagaggaaga atttggaatg aaaagcactt   2700

cgtcagaacc ttctgtggga gccattgaga gaaaagcatg gtccagtgcc ttctgagaaa   2760

ggccagagct ttgggctttc ctgctctgct tttgggtcgt caatttgcca tctctggttc   2820

tgtgctataa tcagaattgt aattatgttc tccagaggcc aatttcatta actctgatta   2880

attagaatca gctagccaga ttagtaacct ctttgtccag ccttgattta cagtgcaggg   2940

taaagtgcag accttaaaaa cagctaagta cctagaagag ctccctgcaa gtgtaaatat   3000

taaggatgac ctgtgcaaaa ttatacccac accagcacta gtggtaatta ttctaaatta   3060

ttgccaaaaa gtttttttta atctgtcttt caagtttaca gaaaagaaag cagtaaatgc   3120

attgatgtca ttttattatg tacatatatc atgtgcattc aagctgtgtg acaagatata   3180

tcaatataaa aacaaggtat atactttatt attttttgaa aacaaggata ttgtgatcaa   3240

ttttaccctg taaaacatat ttctgtattt ataggtctta aacatgatga attttttcta   3300

ttacaagttt atttaaaact gctttctcaa gtcgttattg atacagcaag tgaacctgct   3360

gcagacagaa gcagaggaaa gccaagaaca gcctttattg gtgaagaaaa gaatgaatga   3420

ttctttgtag gcgccatcag ccacttttag aagccatcag ccagtgtgtt gggaaaagag   3480

gtttgtcaag tgttggccta tgggaaggtg gtcaatgaat gttttgatga aatgaatgtt   3540

tttgtataat ggccttaaac ttttctggaa gtatttcaaa taaattacat tattaagtca   3600

tcctc                                                               3605


<210>  1580
<211>  526
<212>  PRT
<213>  Homo sapiens

<400>  1580


Met Val Ala Lys Asp Tyr Pro Phe Tyr Leu Thr Val Lys Arg Ala Asn 
1               5                   10                  15      


Cys Ser Leu Glu Leu Pro Pro Ala Ser Gly Pro Ala Lys Asp Ala Glu 
            20                  25                  30          


Glu Pro Ser Asn Lys Arg Val Lys Pro Leu Ser Arg Val Thr Ser Leu 
        35                  40                  45              


Ala Asn Leu Ile Pro Pro Val Lys Ala Thr Pro Leu Lys Arg Phe Ser 
    50                  55                  60                  


Gln Thr Leu Gln Arg Ser Ile Ser Phe Arg Ser Glu Ser Arg Pro Asp 
65                  70                  75                  80  


Ile Leu Ala Pro Arg Pro Trp Ser Arg Asn Ala Ala Pro Ser Ser Thr 
                85                  90                  95      


Lys Arg Arg Asp Ser Lys Leu Trp Ser Glu Thr Phe Asp Val Cys Val 
            100                 105                 110         


Asn Gln Met Leu Thr Ser Lys Glu Ile Lys Arg Gln Glu Ala Ile Phe 
        115                 120                 125             


Glu Leu Ser Gln Gly Glu Glu Asp Leu Ile Glu Asp Leu Lys Leu Ala 
    130                 135                 140                 


Lys Lys Ala Tyr His Asp Pro Met Leu Lys Leu Ser Ile Met Thr Glu 
145                 150                 155                 160 


Gln Glu Leu Asn Gln Ile Phe Gly Thr Leu Asp Ser Leu Ile Pro Leu 
                165                 170                 175     


His Glu Glu Leu Leu Ser Gln Leu Arg Asp Val Arg Lys Pro Asp Gly 
            180                 185                 190         


Ser Thr Glu His Val Gly Pro Ile Leu Val Gly Trp Leu Pro Cys Leu 
        195                 200                 205             


Ser Ser Tyr Asp Ser Tyr Cys Ser Asn Gln Val Ala Ala Lys Ala Leu 
    210                 215                 220                 


Leu Asp His Lys Lys Gln Asp His Arg Val Gln Asp Phe Leu Gln Arg 
225                 230                 235                 240 


Cys Leu Glu Ser Pro Phe Ser Arg Lys Leu Asp Leu Trp Asn Phe Leu 
                245                 250                 255     


Asp Ile Pro Arg Ser Arg Leu Val Lys Tyr Pro Leu Leu Leu Arg Glu 
            260                 265                 270         


Ile Leu Arg His Thr Pro Asn Asp Asn Pro Asp Gln Gln His Leu Glu 
        275                 280                 285             


Glu Ala Ile Asn Ile Ile Gln Gly Ile Val Ala Glu Ile Asn Thr Lys 
    290                 295                 300                 


Thr Gly Glu Ser Glu Cys Arg Tyr Tyr Lys Glu Arg Leu Leu Tyr Leu 
305                 310                 315                 320 


Glu Glu Gly Gln Lys Asp Ser Leu Ile Asp Ser Ser Arg Val Leu Cys 
                325                 330                 335     


Cys His Gly Glu Leu Lys Asn Asn Arg Gly Val Lys Leu His Val Phe 
            340                 345                 350         


Leu Phe Gln Glu Val Leu Val Ile Thr Arg Ala Val Thr His Asn Glu 
        355                 360                 365             


Gln Leu Cys Tyr Gln Leu Tyr Arg Gln Pro Ile Pro Val Lys Asp Leu 
    370                 375                 380                 


Leu Leu Glu Asp Leu Gln Asp Gly Glu Val Arg Leu Gly Gly Ser Leu 
385                 390                 395                 400 


Arg Gly Ala Phe Ser Asn Asn Glu Arg Ile Lys Asn Phe Phe Arg Val 
                405                 410                 415     


Ser Phe Lys Asn Gly Ser Gln Ser Gln Thr His Ser Leu Gln Ala Asn 
            420                 425                 430         


Asp Thr Phe Asn Lys Gln Gln Trp Leu Asn Cys Ile Arg Gln Ala Lys 
        435                 440                 445             


Glu Thr Val Leu Cys Ala Ala Gly Gln Ala Gly Val Leu Asp Ser Glu 
    450                 455                 460                 


Gly Ser Phe Leu Asn Pro Thr Thr Gly Ser Arg Glu Leu Gln Gly Glu 
465                 470                 475                 480 


Thr Lys Leu Glu Gln Met Asp Gln Ser Asp Ser Glu Ser Asp Cys Ser 
                485                 490                 495     


Met Asp Thr Ser Glu Val Ser Leu Asp Cys Glu Arg Met Glu Gln Thr 
            500                 505                 510         


Asp Ser Ser Cys Gly Asn Ser Arg His Gly Glu Ser Asn Val 
        515                 520                 525     

<210>  1581
<211>  3628
<212>  DNA
<213>  Homo sapiens

<400>  1581
gccgccgcag ccgccgccgc cgcggtgagt tttccagcct ggagaggccg aaccagcgcg     60

ggggtcgagg agacctgagc ctgccatact gagtctatgg acagttccac agcaatgaat    120

caatgcagct gtagaggaat ggaagaaaac aaggaaaggc ctaaacggca gcggcaaaac    180

aactttccca tgtttccctc tcctaaagcc tggaatttca gagggcgaaa acggaaacag    240

agcacccaag atgaagatgc tgttagcctt tgcagtctcg acataagtga gcctagtaat    300

aaacgggtca aacccctttc ccgagtcacg tcgctagcaa acctcatccc gcccgtgaag    360

gccacgccat taaagcgctt cagtcaaacc ctgcagcgct ccattagctt ccgcagtgag    420

agccgccctg acatcctcgc cccccgaccc tggtccagaa atgccgcccc ctcgagcacg    480

aaacggagag atagcaagct gtggagtgag accttcgatg tgtgcgtcaa tcagatgctt    540

acatccaagg aaatcaaacg tcaggaggcg atctttgagc tttcccaagg agaagaagac    600

ttgatagaag acttgaaatt agcaaaaaag gcctatcatg accccatgct gaaactctcc    660

ataatgacag aacaagagtt gaatcaaatt tttggaacac tggactctct aattcctcta    720

catgaagagc tccttagtca gcttcgagat gttaggaagc ctgatggctc gactgaacat    780

gttggtccca tcctcgtggg ctggctccct tgcctcagct cctatgatag ctactgcagc    840

aatcaagtag ccgccaaagc tctgctggac cacaaaaagc aagatcaccg agtccaggat    900

ttcctacagc gatgtttaga atcccccttt agccgcaaac tagatctctg gaatttcctc    960

gatattccaa gaagccgcct ggtaaaatac cctctgcttc tccgagaaat cttgaggcac   1020

acaccaaatg ataatccaga tcagcagcac ttggaagaag ctataaatat cattcaggga   1080

attgtggcag aaatcaacac caagactggt gaatctgaat gccgctatta taaagagcgg   1140

cttctttact tggaagaagg ccagaaagac tccctgatcg acagctctcg agtcttgtgt   1200

tgtcatggtg aactgaagaa caatcggggc gtgaaactgc atgttttcct gttccaagaa   1260

gtgcttgtga tcactcgagc cgtcacccac aatgagcagc tttgctacca gctgtaccgt   1320

cagccaatcc ccgtgaaaga cctcctgctg gaagacctcc aggatggaga agtgaggctg   1380

ggtggctccc tgcgaggggc attcagcaac aatgagagaa ttaaaaactt cttcagagtc   1440

agtttcaaaa atggatccca aagtcagacc cactcgctac aagccaatga cactttcaac   1500

aaacagcagt ggcttaactg tattcgtcaa gccaaagaaa cagttttgtg tgctgccggg   1560

caagctgggg tgcttgactc cgagggatcg ttcctaaatc ccaccaccgg gagcagagag   1620

ctacagggag aaacaaaact tgagcagatg gaccaatcgg acagtgagtc agactgtagt   1680

atggacacga gtgaggtcag cctcgactgt gagcgcatgg aacagacaga ctcttcctgt   1740

ggaaacagca ggcacggtga aagtaacgtc tgacagaagc atgtgcactt cgggaagcag   1800

gcctgcatct tacctgtaca gtatttgcat tccacagatg gaacggtttg gagaagcact   1860

ttttcatact tttgtgaaag tatacatgtt ggcccagtct ctcgtatctg tacctttgtc   1920

cctagtactg taactgccaa tctgtctgtg taagctggaa tctgtggcaa ctattaccct   1980

gtgttgtatt tcccaagtgt ctggatggat ggagaggtac tcaaacaagt tactttcagt   2040

tgtcctgctg gattttaaaa aaatagaaaa agaatctcaa aactactgtt ttacatagat   2100

tgtttgaaga gtccttcctc ttgtgcttct gtaccacttt cccagctctt agatgtggta   2160

gctaaaggca cggaatttag acggccttgt aaatagggca tgaggaactc atctgtgtat   2220

tgggatggta ttagagagag aatcaggaaa gaccaactca tgaagtgaac ttggtttgat   2280

cttactcaac tagaaagctt gaaaacatcc ctggggattc tgaaggctta attttgcaaa   2340

ggaggatgca ttgtctgaac tttgcaactt catccagtgc aagtttgatg caagaatgta   2400

ttaggacata aaatagaggc tgaccttaaa agggccagga cagaagcggc tgccagctct   2460

gaatctttaa ctgaaatgca catggcacca ggaggtgtct ctcatagttg gttgctagcc   2520

taaaacatca gaatagaacc caaagggctt aggaaggcct gccaggataa caagaaggcc   2580

ctgtattcat tgtgtttcat ctgcctaggc ctactcatta ttttagagaa tgaatgaagc   2640

aacaaggaag agagaccatg actctatcga tgacactgtt tatagaaaca caggagagga   2700

agaatttgga atgaaaagca cttcgtcaga accttctgtg ggagccattg agagaaaagc   2760

atggtccagt gccttctgag aaaggccaga gctttgggct ttcctgctct gcttttgggt   2820

cgtcaatttg ccatctctgg ttctgtgcta taatcagaat tgtaattatg ttctccagag   2880

gccaatttca ttaactctga ttaattagaa tcagctagcc agattagtaa cctctttgtc   2940

cagccttgat ttacagtgca gggtaaagtg cagaccttaa aaacagctaa gtacctagaa   3000

gagctccctg caagtgtaaa tattaaggat gacctgtgca aaattatacc cacaccagca   3060

ctagtggtaa ttattctaaa ttattgccaa aaagtttttt ttaatctgtc tttcaagttt   3120

acagaaaaga aagcagtaaa tgcattgatg tcattttatt atgtacatat atcatgtgca   3180

ttcaagctgt gtgacaagat atatcaatat aaaaacaagg tatatacttt attatttttt   3240

gaaaacaagg atattgtgat caattttacc ctgtaaaaca tatttctgta tttataggtc   3300

ttaaacatga tgaatttttt ctattacaag tttatttaaa actgctttct caagtcgtta   3360

ttgatacagc aagtgaacct gctgcagaca gaagcagagg aaagccaaga acagccttta   3420

ttggtgaaga aaagaatgaa tgattctttg taggcgccat cagccacttt tagaagccat   3480

cagccagtgt gttgggaaaa gaggtttgtc aagtgttggc ctatgggaag gtggtcaatg   3540

aatgttttga tgaaatgaat gtttttgtat aatggcctta aacttttctg gaagtatttc   3600

aaataaatta cattattaag tcatcctc                                      3628


<210>  1582
<211>  558
<212>  PRT
<213>  Homo sapiens

<400>  1582


Met Asp Ser Ser Thr Ala Met Asn Gln Cys Ser Cys Arg Gly Met Glu 
1               5                   10                  15      


Glu Asn Lys Glu Arg Pro Lys Arg Gln Arg Gln Asn Asn Phe Pro Met 
            20                  25                  30          


Phe Pro Ser Pro Lys Ala Trp Asn Phe Arg Gly Arg Lys Arg Lys Gln 
        35                  40                  45              


Ser Thr Gln Asp Glu Asp Ala Val Ser Leu Cys Ser Leu Asp Ile Ser 
    50                  55                  60                  


Glu Pro Ser Asn Lys Arg Val Lys Pro Leu Ser Arg Val Thr Ser Leu 
65                  70                  75                  80  


Ala Asn Leu Ile Pro Pro Val Lys Ala Thr Pro Leu Lys Arg Phe Ser 
                85                  90                  95      


Gln Thr Leu Gln Arg Ser Ile Ser Phe Arg Ser Glu Ser Arg Pro Asp 
            100                 105                 110         


Ile Leu Ala Pro Arg Pro Trp Ser Arg Asn Ala Ala Pro Ser Ser Thr 
        115                 120                 125             


Lys Arg Arg Asp Ser Lys Leu Trp Ser Glu Thr Phe Asp Val Cys Val 
    130                 135                 140                 


Asn Gln Met Leu Thr Ser Lys Glu Ile Lys Arg Gln Glu Ala Ile Phe 
145                 150                 155                 160 


Glu Leu Ser Gln Gly Glu Glu Asp Leu Ile Glu Asp Leu Lys Leu Ala 
                165                 170                 175     


Lys Lys Ala Tyr His Asp Pro Met Leu Lys Leu Ser Ile Met Thr Glu 
            180                 185                 190         


Gln Glu Leu Asn Gln Ile Phe Gly Thr Leu Asp Ser Leu Ile Pro Leu 
        195                 200                 205             


His Glu Glu Leu Leu Ser Gln Leu Arg Asp Val Arg Lys Pro Asp Gly 
    210                 215                 220                 


Ser Thr Glu His Val Gly Pro Ile Leu Val Gly Trp Leu Pro Cys Leu 
225                 230                 235                 240 


Ser Ser Tyr Asp Ser Tyr Cys Ser Asn Gln Val Ala Ala Lys Ala Leu 
                245                 250                 255     


Leu Asp His Lys Lys Gln Asp His Arg Val Gln Asp Phe Leu Gln Arg 
            260                 265                 270         


Cys Leu Glu Ser Pro Phe Ser Arg Lys Leu Asp Leu Trp Asn Phe Leu 
        275                 280                 285             


Asp Ile Pro Arg Ser Arg Leu Val Lys Tyr Pro Leu Leu Leu Arg Glu 
    290                 295                 300                 


Ile Leu Arg His Thr Pro Asn Asp Asn Pro Asp Gln Gln His Leu Glu 
305                 310                 315                 320 


Glu Ala Ile Asn Ile Ile Gln Gly Ile Val Ala Glu Ile Asn Thr Lys 
                325                 330                 335     


Thr Gly Glu Ser Glu Cys Arg Tyr Tyr Lys Glu Arg Leu Leu Tyr Leu 
            340                 345                 350         


Glu Glu Gly Gln Lys Asp Ser Leu Ile Asp Ser Ser Arg Val Leu Cys 
        355                 360                 365             


Cys His Gly Glu Leu Lys Asn Asn Arg Gly Val Lys Leu His Val Phe 
    370                 375                 380                 


Leu Phe Gln Glu Val Leu Val Ile Thr Arg Ala Val Thr His Asn Glu 
385                 390                 395                 400 


Gln Leu Cys Tyr Gln Leu Tyr Arg Gln Pro Ile Pro Val Lys Asp Leu 
                405                 410                 415     


Leu Leu Glu Asp Leu Gln Asp Gly Glu Val Arg Leu Gly Gly Ser Leu 
            420                 425                 430         


Arg Gly Ala Phe Ser Asn Asn Glu Arg Ile Lys Asn Phe Phe Arg Val 
        435                 440                 445             


Ser Phe Lys Asn Gly Ser Gln Ser Gln Thr His Ser Leu Gln Ala Asn 
    450                 455                 460                 


Asp Thr Phe Asn Lys Gln Gln Trp Leu Asn Cys Ile Arg Gln Ala Lys 
465                 470                 475                 480 


Glu Thr Val Leu Cys Ala Ala Gly Gln Ala Gly Val Leu Asp Ser Glu 
                485                 490                 495     


Gly Ser Phe Leu Asn Pro Thr Thr Gly Ser Arg Glu Leu Gln Gly Glu 
            500                 505                 510         


Thr Lys Leu Glu Gln Met Asp Gln Ser Asp Ser Glu Ser Asp Cys Ser 
        515                 520                 525             


Met Asp Thr Ser Glu Val Ser Leu Asp Cys Glu Arg Met Glu Gln Thr 
    530                 535                 540                 


Asp Ser Ser Cys Gly Asn Ser Arg His Gly Glu Ser Asn Val 
545                 550                 555             

<210>  1583
<211>  9467
<212>  DNA
<213>  Homo sapiens

<400>  1583
gcggccaggg gcgggcggcc gcagagcagc accggccgtg gctccggtag cagcaagttc     60

gaaccccgct cccgctccgc ttcggttctc gctccttcgg cccttgggcc tccaaacacc    120

agtccccggc agctcgttgc gcattgcgct ctccccgcca ccaggatgcc ggtaaccgag    180

aaggatctag ctgaggacgc gccttggaag aagatccagc agaacacgtt cacacgctgg    240

tgcaacgagc acctcaagtg cgtgaacaaa cgcatcggca acctgcagac cgacctgagc    300

gacgggctgc ggctcatcgc gctgctcgag gtgctcagcc agaagcgcat gtaccgcaag    360

taccatcagc ggcccacctt tcgccagatg cagctcgaga atgtgtccgt ggcgctcgag    420

ttcctggacc gtgagagcat caagctcgtg tccatcgata gcaaagccat tgtggatggg    480

aacctgaagc tcatcttggg tctggtgtgg acgctgatcc tccactactc catctccatg    540

cccgtgtggg aggatgaagg ggatgatgat gccaagaagc agacgccaaa gcagaggctg    600

ctggggtgga ttcagaacaa gatcccctac ttgcccatca ccaactttaa ccagaactgg    660

caagacggca aagccctggg agccctggta gacagctgtg ctccaggtct gtgcccagac    720

tgggaatcct gggacccgca gaagcctgtg gataatgcac gagaagccat gcagcaggca    780

gatgactggc tgggtgtccc acaggtcatc actcctgaag aaatcattca cccggatgtg    840

gacgagcact cagttatgac ttacctgtcc cagttcccca aagccaagct caagccgggg    900

gctcctctca aacccaaact caacccgaag aaagccaggg cctatggcag aggaatcgag    960

cccactggaa acatggtgaa gcagccagcc aagttcactg tggacaccat cagcgccggg   1020

caaggagacg tgatggtgtt tgttgaggac ccagaaggga acaaagagga ggcacaagtg   1080

acccctgaca gtgacaagaa caagacatac tctgtggagt atctgcccaa ggtcaccggg   1140

ctacacaaag tcacagtcct ctttgcagga cagcacatct ccaagagccc atttgaagtg   1200

agtgttgaca aggcccaggg agatgccagt aaagtcactg caaaaggtcc agggttggaa   1260

gctgtaggga acatcgccaa taagcccacc tactttgaca tctatacggc aggagctggt   1320

gtgggtgaca ttggtgtgga ggtggaagat ccccagggga agaacaccgt ggagttgctc   1380

gtggaagaca aaggaaacca ggtgtatcga tgtgtgtaca aacccatgca gcctggccct   1440

cacgtggtca agatcttctt tgctggggac actattccta agagtccctt cgttgtgcag   1500

gttggggaag cctgcaatcc aaatgcctgc cgggccagtg gccgaggcct acaacccaaa   1560

ggcgtccgta tccgggagac cacagatttc aaggttgaca ccaaagctgc aggaagtggg   1620

gagctcggtg taaccatgaa gggtcctaag ggtctggagg agctggtgaa gcagaaagac   1680

tttctggatg gggtctacgc attcgagtat taccccagca ccccggggag atacagcatt   1740

gccatcacat gggggggaca ccacattcca aagagcccct ttgaagttca agttggccct   1800

gaagcgggta tgcagaaagt ccgtgcttgg ggccctgggc tccatggtgg gattgtcggg   1860

cggtcagcgg acttcgtggt agaatccatt ggctctgaag tggggtctct ggggtttgcc   1920

attgaaggcc cctctcaggc aaagattgag tacaacgacc agaatgatgg atcgtgtgat   1980

gtcaaatact ggcccaagga gcctggcgaa tatgctgttc acatcatgtg tgacgacgaa   2040

gacatcaagg acagcccgta catggccttc atccacccag ccacgggagg ctacaaccct   2100

gatctggttc gagcatacgg gccaggtttg gagaaatctg gatgcattgt caacaacctg   2160

gccgagttca ctgtggatcc taaggatgct ggaaaagctc ccttaaagat atttgctcag   2220

gatggggaag gccaacgcat tgacatccag atgaagaacc ggatggacgg cacatatgca   2280

tgctcataca ccccggtgaa ggccatcaag cacaccattg ctgtggtctg gggaggcgtg   2340

aacatcccgc acagccccta cagggtcaac atcgggcaag gtagccatcc tcagaaggtc   2400

aaagtgtttg ggccaggtgt ggagagaagt ggtctgaagg caaatgaacc tacacacttc   2460

acggtggact gtactgaggc tggggaaggt gatgtcagtg ttggcattaa gtgtgatgcc   2520

cgggtgttaa gtgaagatga ggaagacgtg gattttgaca ttattcacaa tgccaatgat   2580

acgttcacag tcaaatatgt gcctcctgct gctgggcgat acactatcaa agttctcttt   2640

gcatctcagg aaatccccgc cagccctttc agagtcaaag ttgacccttc ccacgatgcc   2700

agcaaagtga aggcagaagg cccagggctc agcaaagcag gtgtggaaaa tgggaaaccg   2760

acccacttca ctgtctacac caagggggct gggaaagccc cgctcaacgt gcagttcaac   2820

agccctcttc ctggcgatgc agtgaaggat ttggatatca tcgataatta tgactactct   2880

cacacggtta aatatacacc cacccaacag ggcaacatgc aggttctggt gacttacggt   2940

ggcgatccca tccctaaaag ccctttcact gtgggtgttg ctgcaccgct ggatctgagc   3000

aagataaaac tcaatgggct ggaaaacagg gtggaagttg ggaaggatca ggagttcacc   3060

gttgatacca ggggggcagg aggccagggg aagctggacg tgacaatcct cagcccctct   3120

cggaaggtcg tgccatgcct agtgacacct gtgacaggcc gggagaacag cacggccaag   3180

ttcatccctc gggaggaggg gctgtatgct gtagacgtga cctacgatgg acaccctgtg   3240

cccgggagcc cctacacagt ggaggcctcg ctgccaccag atcccagcaa ggtgaaggcc   3300

cacggtcccg gcctcgaagg tggtctcgtg ggcaagcctg ccgagttcac catcgatacc   3360

aaaggagctg gtactggagg tctgggctta acggtggaag gtccgtgcga ggccaaaatc   3420

gagtgctccg acaatggtga tgggacctgc tccgtctctt accttcccac aaaacccggg   3480

gagtacttcg tcaacatcct ctttgaagaa gtccacatac ctgggtctcc cttcaaagct   3540

gacattgaaa tgccctttga cccctctaaa gtcgtggcat cggggccagg tctcgagcac   3600

gggaaggtgg gtgaagctgg cctccttagc gtcgactgct cggaagcggg accgggggcc   3660

ctgggcctgg aagctgtctc ggactcggga acaaaagccg aagtcagtat tcagaacaac   3720

aaagatggca cctacgcggt gacctacgtg cccctgacgg ccggcatgta cacgttgacc   3780

atgaagtatg gtggcgaact cgtgccacac ttccccgccc gggtcaaggt ggagcccgcc   3840

gtggacacca gcaggatcaa agtctttgga ccaggaatag aagggaaaga tgtgttccgg   3900

gaagctacca ccgactttac agttgactct cggccgctga cccaggttgg gggtgaccac   3960

atcaaggccc acattgccaa cccctcaggg gcctccaccg agtgctttgt cacagacaat   4020

gcggatggga cctaccaggt ggaatacaca ccctttgaga aaggtctcca tgtagtggag   4080

gtgacatatg atgacgtgcc tatcccaaac agtcccttca aggtggctgt cactgaaggc   4140

tgccagccat ctagggtgca agcccaagga cctggattga aagaggcctt taccaacaag   4200

cccaatgtct tcaccgtggt taccagaggc gcaggaattg gtgggcttgg cataactgtt   4260

gagggaccat cagagtcgaa gataaattgc agagacaaca aggatggcag ctgcagtgct   4320

gagtacattc ctttcgcacc gggggattac gatgttaata tcacatatgg aggagcccac   4380

atccccggca gccccttcag ggttcctgtg aaggatgttg tggaccccag caaggtcaag   4440

attgccggcc ccgggctggg ctcaggcgtc cgagcccgtg tcctgcagtc cttcacggtg   4500

gacagcagca aggctggcct ggctccgctg gaagtgaggg ttctgggccc acgaggcttg   4560

gtggagccag tgaacgtggt ggacaatgga gatggcacac acacagtaac ctacacccca   4620

tctcaggagg gaccttacat ggtctcagtt aaatatgctg atgaagagat tcctcgcagt   4680

cccttcaagg tcaaggtcct tcccacatat gatgccagca aagtgactgc cagtggcccc   4740

ggccttagtt cctatggtgt gcctgccagt ctacctgtgg actttgcaat tgatgcccga   4800

gatgccgggg aaggcctgct tgctgttcaa ataacggacc aagaaggaaa acccaaaaga   4860

gccattgtcc atgacaataa agatggcacg tatgctgtca cctacatccc cgacaagact   4920

gggcgctata tgattggagt cacctacggg ggtgacgaca tcccactttc tccttatcgc   4980

atccgagcca cacagacggg tgatgccagc aagtgcctgg ccacgggtcc tggaatcgcc   5040

tccactgtga aaactggcga agaagtaggc tttgtggttg atgccaagac tgccgggaag   5100

ggtaaagtga cctgcacggt tctgacccca gatggcactg aggccgaggc cgatgtcatt   5160

gagaatgaag atggaaccta tgacatcttc tacacagctg ccaagccggg cacatatgtg   5220

atctatgtgc gcttcggtgg tgttgatatt cctaacagcc ccttcactgt catggccaca   5280

gatggggaag tcacagccgt ggaggaggca ccggtaaatg catgtccccc tggattcagg   5340

ccctgggtga ccgaagaggc ctatgtccca gtgagtgaca tgaacggcct gggatttaag   5400

ccttttgacc tggtcattcc gtttgctgtc aggaaaggag aaatcactgg agaggtccac   5460

atgccttctg ggaagacagc cacacctgag attgtggaca acaaggacgg cacggtcact   5520

gttagatatg cccccactga ggtcgggctc catgagatgc acatcaaata catgggcagc   5580

cacatccctg agagcccact ccagttctac gtgaactacc ccaacagtgg aagtgtttct   5640

gcatacggtc caggcctcgt gtatggagtg gccaacaaaa ctgccacctt caccatcgtc   5700

acagaggatg caggagaagg tggtctggac ttggctattg agggcccctc aaaagcagaa   5760

atcagctgca ttgacaataa agatgggaca tgcacagtga cctacctgcc gactctgcca   5820

ggcgactaca gcattctggt caagtacaat gacaagcaca tccctggcag ccccttcaca   5880

gccaagatca cagatgacag caggcggtgc tcccaggtga agttgggctc agccgctgac   5940

ttcctgctcg acatcagtga gactgacctc agcagcctga cggccagcat taaggcccca   6000

tctggccgag acgagccctg tctcctgaag aggctgccca acaaccacat tggcatctcc   6060

ttcatccccc gggaagtggg cgaacatctg gtcagcatca agaaaaatgg caaccatgtg   6120

gccaacagcc ccgtgtctat catggtggtc cagtcggaga ttggtgacgc ccgccgagcc   6180

aaagtctatg gccgcggcct gtcagaaggc cggactttcg agatgtctga cttcatcgtg   6240

gacacaaggg atgcaggtta tggtggcata tccttggcgg tggaaggccc cagcaaagtg   6300

gacatccaga cggaggacct ggaagatggc acctgcaaag tctcctactt ccctaccgtg   6360

cctggggttt atatcgtctc caccaaattc gctgacgagc acgtgcctgg gagcccattt   6420

accgtgaaga tcagtgggga gggaagagtc aaagagagca tcacccgcac cagtcgggcc   6480

ccgtccgtgg ccactgtcgg gagcatttgt gacctgaacc tgaaaatccc agaaatcaac   6540

agcagtgata tgtcggccca cgtcaccagc ccctctggcc gtgtgactga ggcagagatt   6600

gtgcccatgg ggaagaactc acactgcgtc cggtttgtgc cccaggagat gggcgtgcac   6660

acggtcagcg tcaagtaccg tgggcagcac gtcaccggca gccccttcca gttcaccgtg   6720

gggccacttg gtgaaggagg cgcccacaag gtgcgggcag gaggccctgg cctggagaga   6780

ggagaagcgg gagtcccagc tgagttcagc atttggaccc gggaagcagg cgctggaggc   6840

ctctccatcg ctgttgaggg ccccagtaag gccgagatta cattcgatga ccataaaaat   6900

gggtcgtgcg gtgtatctta tattgcccaa gagcctggta actacgaggt gtccatcaag   6960

ttcaatgatg agcacatccc ggaaagcccc tacctggtgc cggtcatcgc accctccgac   7020

gacgcccgcc gcctcactgt tatgagcctt caggaatcgg gattaaaagt taaccagcca   7080

gcatcctttg ctataaggtt gaatggcgca aaaggcaaga ttgatgcaaa ggtgcacagc   7140

ccctctggag ccgtggagga gtgccacgtg tctgagctgg agccagataa gtatgctgtt   7200

cgcttcatcc ctcatgagaa tggtgtccac accatcgatg tcaagttcaa tgggagccac   7260

gtggttggaa gccccttcaa agtgcgcgtt ggggagcctg gacaagcggg gaaccctgcc   7320

ctggtgtccg cctatggcac gggactcgaa gggggcacca caggtatcca gtcggaattc   7380

tttattaaca ccacccgagc aggtccaggg acattatccg tcaccatcga aggcccatcc   7440

aaggttaaaa tggattgcca ggaaacacct gaagggtaca aagtcatgta cacccccatg   7500

gctcctggta actacctgat cagcgtcaaa tacggtgggc ccaaccacat cgtgggcagt   7560

cccttcaagg ccaaggtgac aggccagcgt ctagttagcc ctggctcagc caacgagacc   7620

tcatccatcc tggtggagtc agtgaccagg tcgtctacag agacctgcta tagcgccatt   7680

cccaaggcat cctcggacgc cagcaaggtg acctctaagg gggcagggct ctcaaaggcc   7740

tttgtgggcc agaagagttc cttcctggtg gactgcagca aagctggctc caacatgctg   7800

ctgatcgggg tccatgggcc caccaccccc tgcgaggagg tctccatgaa gcatgtaggc   7860

aaccagcaat acaacgtcac atacgtcgtc aaggagaggg gcgattatgt gctggctgtg   7920

aagtgggggg aggaacacat ccctggcagc ccttttcatg tcacagtgcc ttaaaacagt   7980

tttctcaaat cctggagaga gttcttgtgg ttgcttttgt tgcttgtttg taattcattt   8040

tatacaaagc cctccagcct gtttgtgggg ctgaaacccc atccctaaaa tattgctgtt   8100

gtaaaatgcc ttcagaaata agtcctagac tggactcttg agggacatat tggagaatct   8160

taagaaatgc aagcttgttc agggggctga gaagatcctg agtacactag gtgcaaacca   8220

gaactcttgg tggaacagac cagccactgc agcagacaga ccaggaacac aatgagactg   8280

acatttcaaa aaaacaaaac tggctagcct gagctgctgg ttcactcttc agcatttatg   8340

aaacaaggct aggggaagat gggcagagaa aaaggggaca cctagtttgg ttgtcatttg   8400

gcaaaggaga tgacttaaaa tccgcttaat ctcttccagt gtccgtgtta atgtatttgg   8460

ctattagatc actagcactg ctttaccgct cctcatcgcc aacaccccca tgctctgtgg   8520

ccttcttaca cttctcagag ggcagagtgg cagccgggca ccctacagaa actcagaggg   8580

cagagtggca gccaggccca catgtctctc aagtacctgt cccctcgctc tggtgattat   8640

ttcttgcaga atcaccacac gagaccatcc cggcagtcat ggttttgctt tagttttcca   8700

agtccgtttc agtcccttcc ttggtctgaa gaaattctgc agtggcgagc agtttcccac   8760

ttgccaaaga tcccttttaa ccaacactag cccttgtttt taacacacgc tccagccctt   8820

catcagcctg ggcagtctta ccaaaatgtt taaagtgatc tcagaggggc ccatggatta   8880

acgccctcat cccaaggtcc gtcccatgac ataacactcc acacccgccc cagccaactt   8940

catgggtcac tttttctgga aaataatgat ctgtacagac aggacagaat gaaactcctg   9000

cgggtctttg gcctgaaagt tgggaatggt tgggggagag aagggcagca gcttattggt   9060

ggtcttttca ccattggcag aaacagtgag agctgtgtgg tgcagaaatc cagaaatgag   9120

gtgtagggaa ttttgcctgc cttcctgcag acctgagctg gctttggaat gaggttaaag   9180

tgtcagggac gttgcctgag cccaaatgtg tagtgtggtc tgggcaggca gacctttagg   9240

ttttgctgct tagtcctgag gaagtggcca ctcttgtggc aggtgtagta tctggggcga   9300

gtgttggggg taaaagccca ccctacagaa agtggaacag cccggagcct gatgtgaaag   9360

gaccacgggt gttgtaagct gggacacgga agccaaactg gaatcaaacg ccgactgtaa   9420

attgtatctt ataacttatt aaataaaaca tttgctccgt aaagttg                 9467


<210>  1584
<211>  2602
<212>  PRT
<213>  Homo sapiens

<400>  1584


Met Pro Val Thr Glu Lys Asp Leu Ala Glu Asp Ala Pro Trp Lys Lys 
1               5                   10                  15      


Ile Gln Gln Asn Thr Phe Thr Arg Trp Cys Asn Glu His Leu Lys Cys 
            20                  25                  30          


Val Asn Lys Arg Ile Gly Asn Leu Gln Thr Asp Leu Ser Asp Gly Leu 
        35                  40                  45              


Arg Leu Ile Ala Leu Leu Glu Val Leu Ser Gln Lys Arg Met Tyr Arg 
    50                  55                  60                  


Lys Tyr His Gln Arg Pro Thr Phe Arg Gln Met Gln Leu Glu Asn Val 
65                  70                  75                  80  


Ser Val Ala Leu Glu Phe Leu Asp Arg Glu Ser Ile Lys Leu Val Ser 
                85                  90                  95      


Ile Asp Ser Lys Ala Ile Val Asp Gly Asn Leu Lys Leu Ile Leu Gly 
            100                 105                 110         


Leu Val Trp Thr Leu Ile Leu His Tyr Ser Ile Ser Met Pro Val Trp 
        115                 120                 125             


Glu Asp Glu Gly Asp Asp Asp Ala Lys Lys Gln Thr Pro Lys Gln Arg 
    130                 135                 140                 


Leu Leu Gly Trp Ile Gln Asn Lys Ile Pro Tyr Leu Pro Ile Thr Asn 
145                 150                 155                 160 


Phe Asn Gln Asn Trp Gln Asp Gly Lys Ala Leu Gly Ala Leu Val Asp 
                165                 170                 175     


Ser Cys Ala Pro Gly Leu Cys Pro Asp Trp Glu Ser Trp Asp Pro Gln 
            180                 185                 190         


Lys Pro Val Asp Asn Ala Arg Glu Ala Met Gln Gln Ala Asp Asp Trp 
        195                 200                 205             


Leu Gly Val Pro Gln Val Ile Thr Pro Glu Glu Ile Ile His Pro Asp 
    210                 215                 220                 


Val Asp Glu His Ser Val Met Thr Tyr Leu Ser Gln Phe Pro Lys Ala 
225                 230                 235                 240 


Lys Leu Lys Pro Gly Ala Pro Leu Lys Pro Lys Leu Asn Pro Lys Lys 
                245                 250                 255     


Ala Arg Ala Tyr Gly Arg Gly Ile Glu Pro Thr Gly Asn Met Val Lys 
            260                 265                 270         


Gln Pro Ala Lys Phe Thr Val Asp Thr Ile Ser Ala Gly Gln Gly Asp 
        275                 280                 285             


Val Met Val Phe Val Glu Asp Pro Glu Gly Asn Lys Glu Glu Ala Gln 
    290                 295                 300                 


Val Thr Pro Asp Ser Asp Lys Asn Lys Thr Tyr Ser Val Glu Tyr Leu 
305                 310                 315                 320 


Pro Lys Val Thr Gly Leu His Lys Val Thr Val Leu Phe Ala Gly Gln 
                325                 330                 335     


His Ile Ser Lys Ser Pro Phe Glu Val Ser Val Asp Lys Ala Gln Gly 
            340                 345                 350         


Asp Ala Ser Lys Val Thr Ala Lys Gly Pro Gly Leu Glu Ala Val Gly 
        355                 360                 365             


Asn Ile Ala Asn Lys Pro Thr Tyr Phe Asp Ile Tyr Thr Ala Gly Ala 
    370                 375                 380                 


Gly Val Gly Asp Ile Gly Val Glu Val Glu Asp Pro Gln Gly Lys Asn 
385                 390                 395                 400 


Thr Val Glu Leu Leu Val Glu Asp Lys Gly Asn Gln Val Tyr Arg Cys 
                405                 410                 415     


Val Tyr Lys Pro Met Gln Pro Gly Pro His Val Val Lys Ile Phe Phe 
            420                 425                 430         


Ala Gly Asp Thr Ile Pro Lys Ser Pro Phe Val Val Gln Val Gly Glu 
        435                 440                 445             


Ala Cys Asn Pro Asn Ala Cys Arg Ala Ser Gly Arg Gly Leu Gln Pro 
    450                 455                 460                 


Lys Gly Val Arg Ile Arg Glu Thr Thr Asp Phe Lys Val Asp Thr Lys 
465                 470                 475                 480 


Ala Ala Gly Ser Gly Glu Leu Gly Val Thr Met Lys Gly Pro Lys Gly 
                485                 490                 495     


Leu Glu Glu Leu Val Lys Gln Lys Asp Phe Leu Asp Gly Val Tyr Ala 
            500                 505                 510         


Phe Glu Tyr Tyr Pro Ser Thr Pro Gly Arg Tyr Ser Ile Ala Ile Thr 
        515                 520                 525             


Trp Gly Gly His His Ile Pro Lys Ser Pro Phe Glu Val Gln Val Gly 
    530                 535                 540                 


Pro Glu Ala Gly Met Gln Lys Val Arg Ala Trp Gly Pro Gly Leu His 
545                 550                 555                 560 


Gly Gly Ile Val Gly Arg Ser Ala Asp Phe Val Val Glu Ser Ile Gly 
                565                 570                 575     


Ser Glu Val Gly Ser Leu Gly Phe Ala Ile Glu Gly Pro Ser Gln Ala 
            580                 585                 590         


Lys Ile Glu Tyr Asn Asp Gln Asn Asp Gly Ser Cys Asp Val Lys Tyr 
        595                 600                 605             


Trp Pro Lys Glu Pro Gly Glu Tyr Ala Val His Ile Met Cys Asp Asp 
    610                 615                 620                 


Glu Asp Ile Lys Asp Ser Pro Tyr Met Ala Phe Ile His Pro Ala Thr 
625                 630                 635                 640 


Gly Gly Tyr Asn Pro Asp Leu Val Arg Ala Tyr Gly Pro Gly Leu Glu 
                645                 650                 655     


Lys Ser Gly Cys Ile Val Asn Asn Leu Ala Glu Phe Thr Val Asp Pro 
            660                 665                 670         


Lys Asp Ala Gly Lys Ala Pro Leu Lys Ile Phe Ala Gln Asp Gly Glu 
        675                 680                 685             


Gly Gln Arg Ile Asp Ile Gln Met Lys Asn Arg Met Asp Gly Thr Tyr 
    690                 695                 700                 


Ala Cys Ser Tyr Thr Pro Val Lys Ala Ile Lys His Thr Ile Ala Val 
705                 710                 715                 720 


Val Trp Gly Gly Val Asn Ile Pro His Ser Pro Tyr Arg Val Asn Ile 
                725                 730                 735     


Gly Gln Gly Ser His Pro Gln Lys Val Lys Val Phe Gly Pro Gly Val 
            740                 745                 750         


Glu Arg Ser Gly Leu Lys Ala Asn Glu Pro Thr His Phe Thr Val Asp 
        755                 760                 765             


Cys Thr Glu Ala Gly Glu Gly Asp Val Ser Val Gly Ile Lys Cys Asp 
    770                 775                 780                 


Ala Arg Val Leu Ser Glu Asp Glu Glu Asp Val Asp Phe Asp Ile Ile 
785                 790                 795                 800 


His Asn Ala Asn Asp Thr Phe Thr Val Lys Tyr Val Pro Pro Ala Ala 
                805                 810                 815     


Gly Arg Tyr Thr Ile Lys Val Leu Phe Ala Ser Gln Glu Ile Pro Ala 
            820                 825                 830         


Ser Pro Phe Arg Val Lys Val Asp Pro Ser His Asp Ala Ser Lys Val 
        835                 840                 845             


Lys Ala Glu Gly Pro Gly Leu Ser Lys Ala Gly Val Glu Asn Gly Lys 
    850                 855                 860                 


Pro Thr His Phe Thr Val Tyr Thr Lys Gly Ala Gly Lys Ala Pro Leu 
865                 870                 875                 880 


Asn Val Gln Phe Asn Ser Pro Leu Pro Gly Asp Ala Val Lys Asp Leu 
                885                 890                 895     


Asp Ile Ile Asp Asn Tyr Asp Tyr Ser His Thr Val Lys Tyr Thr Pro 
            900                 905                 910         


Thr Gln Gln Gly Asn Met Gln Val Leu Val Thr Tyr Gly Gly Asp Pro 
        915                 920                 925             


Ile Pro Lys Ser Pro Phe Thr Val Gly Val Ala Ala Pro Leu Asp Leu 
    930                 935                 940                 


Ser Lys Ile Lys Leu Asn Gly Leu Glu Asn Arg Val Glu Val Gly Lys 
945                 950                 955                 960 


Asp Gln Glu Phe Thr Val Asp Thr Arg Gly Ala Gly Gly Gln Gly Lys 
                965                 970                 975     


Leu Asp Val Thr Ile Leu Ser Pro Ser Arg Lys Val Val Pro Cys Leu 
            980                 985                 990         


Val Thr Pro Val Thr Gly Arg Glu  Asn Ser Thr Ala Lys  Phe Ile Pro 
        995                 1000                 1005             


Arg Glu  Glu Gly Leu Tyr Ala  Val Asp Val Thr Tyr  Asp Gly His 
    1010                 1015                 1020             


Pro Val  Pro Gly Ser Pro Tyr  Thr Val Glu Ala Ser  Leu Pro Pro 
    1025                 1030                 1035             


Asp Pro  Ser Lys Val Lys Ala  His Gly Pro Gly Leu  Glu Gly Gly 
    1040                 1045                 1050             


Leu Val  Gly Lys Pro Ala Glu  Phe Thr Ile Asp Thr  Lys Gly Ala 
    1055                 1060                 1065             


Gly Thr  Gly Gly Leu Gly Leu  Thr Val Glu Gly Pro  Cys Glu Ala 
    1070                 1075                 1080             


Lys Ile  Glu Cys Ser Asp Asn  Gly Asp Gly Thr Cys  Ser Val Ser 
    1085                 1090                 1095             


Tyr Leu  Pro Thr Lys Pro Gly  Glu Tyr Phe Val Asn  Ile Leu Phe 
    1100                 1105                 1110             


Glu Glu  Val His Ile Pro Gly  Ser Pro Phe Lys Ala  Asp Ile Glu 
    1115                 1120                 1125             


Met Pro  Phe Asp Pro Ser Lys  Val Val Ala Ser Gly  Pro Gly Leu 
    1130                 1135                 1140             


Glu His  Gly Lys Val Gly Glu  Ala Gly Leu Leu Ser  Val Asp Cys 
    1145                 1150                 1155             


Ser Glu  Ala Gly Pro Gly Ala  Leu Gly Leu Glu Ala  Val Ser Asp 
    1160                 1165                 1170             


Ser Gly  Thr Lys Ala Glu Val  Ser Ile Gln Asn Asn  Lys Asp Gly 
    1175                 1180                 1185             


Thr Tyr  Ala Val Thr Tyr Val  Pro Leu Thr Ala Gly  Met Tyr Thr 
    1190                 1195                 1200             


Leu Thr  Met Lys Tyr Gly Gly  Glu Leu Val Pro His  Phe Pro Ala 
    1205                 1210                 1215             


Arg Val  Lys Val Glu Pro Ala  Val Asp Thr Ser Arg  Ile Lys Val 
    1220                 1225                 1230             


Phe Gly  Pro Gly Ile Glu Gly  Lys Asp Val Phe Arg  Glu Ala Thr 
    1235                 1240                 1245             


Thr Asp  Phe Thr Val Asp Ser  Arg Pro Leu Thr Gln  Val Gly Gly 
    1250                 1255                 1260             


Asp His  Ile Lys Ala His Ile  Ala Asn Pro Ser Gly  Ala Ser Thr 
    1265                 1270                 1275             


Glu Cys  Phe Val Thr Asp Asn  Ala Asp Gly Thr Tyr  Gln Val Glu 
    1280                 1285                 1290             


Tyr Thr  Pro Phe Glu Lys Gly  Leu His Val Val Glu  Val Thr Tyr 
    1295                 1300                 1305             


Asp Asp  Val Pro Ile Pro Asn  Ser Pro Phe Lys Val  Ala Val Thr 
    1310                 1315                 1320             


Glu Gly  Cys Gln Pro Ser Arg  Val Gln Ala Gln Gly  Pro Gly Leu 
    1325                 1330                 1335             


Lys Glu  Ala Phe Thr Asn Lys  Pro Asn Val Phe Thr  Val Val Thr 
    1340                 1345                 1350             


Arg Gly  Ala Gly Ile Gly Gly  Leu Gly Ile Thr Val  Glu Gly Pro 
    1355                 1360                 1365             


Ser Glu  Ser Lys Ile Asn Cys  Arg Asp Asn Lys Asp  Gly Ser Cys 
    1370                 1375                 1380             


Ser Ala  Glu Tyr Ile Pro Phe  Ala Pro Gly Asp Tyr  Asp Val Asn 
    1385                 1390                 1395             


Ile Thr  Tyr Gly Gly Ala His  Ile Pro Gly Ser Pro  Phe Arg Val 
    1400                 1405                 1410             


Pro Val  Lys Asp Val Val Asp  Pro Ser Lys Val Lys  Ile Ala Gly 
    1415                 1420                 1425             


Pro Gly  Leu Gly Ser Gly Val  Arg Ala Arg Val Leu  Gln Ser Phe 
    1430                 1435                 1440             


Thr Val  Asp Ser Ser Lys Ala  Gly Leu Ala Pro Leu  Glu Val Arg 
    1445                 1450                 1455             


Val Leu  Gly Pro Arg Gly Leu  Val Glu Pro Val Asn  Val Val Asp 
    1460                 1465                 1470             


Asn Gly  Asp Gly Thr His Thr  Val Thr Tyr Thr Pro  Ser Gln Glu 
    1475                 1480                 1485             


Gly Pro  Tyr Met Val Ser Val  Lys Tyr Ala Asp Glu  Glu Ile Pro 
    1490                 1495                 1500             


Arg Ser  Pro Phe Lys Val Lys  Val Leu Pro Thr Tyr  Asp Ala Ser 
    1505                 1510                 1515             


Lys Val  Thr Ala Ser Gly Pro  Gly Leu Ser Ser Tyr  Gly Val Pro 
    1520                 1525                 1530             


Ala Ser  Leu Pro Val Asp Phe  Ala Ile Asp Ala Arg  Asp Ala Gly 
    1535                 1540                 1545             


Glu Gly  Leu Leu Ala Val Gln  Ile Thr Asp Gln Glu  Gly Lys Pro 
    1550                 1555                 1560             


Lys Arg  Ala Ile Val His Asp  Asn Lys Asp Gly Thr  Tyr Ala Val 
    1565                 1570                 1575             


Thr Tyr  Ile Pro Asp Lys Thr  Gly Arg Tyr Met Ile  Gly Val Thr 
    1580                 1585                 1590             


Tyr Gly  Gly Asp Asp Ile Pro  Leu Ser Pro Tyr Arg  Ile Arg Ala 
    1595                 1600                 1605             


Thr Gln  Thr Gly Asp Ala Ser  Lys Cys Leu Ala Thr  Gly Pro Gly 
    1610                 1615                 1620             


Ile Ala  Ser Thr Val Lys Thr  Gly Glu Glu Val Gly  Phe Val Val 
    1625                 1630                 1635             


Asp Ala  Lys Thr Ala Gly Lys  Gly Lys Val Thr Cys  Thr Val Leu 
    1640                 1645                 1650             


Thr Pro  Asp Gly Thr Glu Ala  Glu Ala Asp Val Ile  Glu Asn Glu 
    1655                 1660                 1665             


Asp Gly  Thr Tyr Asp Ile Phe  Tyr Thr Ala Ala Lys  Pro Gly Thr 
    1670                 1675                 1680             


Tyr Val  Ile Tyr Val Arg Phe  Gly Gly Val Asp Ile  Pro Asn Ser 
    1685                 1690                 1695             


Pro Phe  Thr Val Met Ala Thr  Asp Gly Glu Val Thr  Ala Val Glu 
    1700                 1705                 1710             


Glu Ala  Pro Val Asn Ala Cys  Pro Pro Gly Phe Arg  Pro Trp Val 
    1715                 1720                 1725             


Thr Glu  Glu Ala Tyr Val Pro  Val Ser Asp Met Asn  Gly Leu Gly 
    1730                 1735                 1740             


Phe Lys  Pro Phe Asp Leu Val  Ile Pro Phe Ala Val  Arg Lys Gly 
    1745                 1750                 1755             


Glu Ile  Thr Gly Glu Val His  Met Pro Ser Gly Lys  Thr Ala Thr 
    1760                 1765                 1770             


Pro Glu  Ile Val Asp Asn Lys  Asp Gly Thr Val Thr  Val Arg Tyr 
    1775                 1780                 1785             


Ala Pro  Thr Glu Val Gly Leu  His Glu Met His Ile  Lys Tyr Met 
    1790                 1795                 1800             


Gly Ser  His Ile Pro Glu Ser  Pro Leu Gln Phe Tyr  Val Asn Tyr 
    1805                 1810                 1815             


Pro Asn  Ser Gly Ser Val Ser  Ala Tyr Gly Pro Gly  Leu Val Tyr 
    1820                 1825                 1830             


Gly Val  Ala Asn Lys Thr Ala  Thr Phe Thr Ile Val  Thr Glu Asp 
    1835                 1840                 1845             


Ala Gly  Glu Gly Gly Leu Asp  Leu Ala Ile Glu Gly  Pro Ser Lys 
    1850                 1855                 1860             


Ala Glu  Ile Ser Cys Ile Asp  Asn Lys Asp Gly Thr  Cys Thr Val 
    1865                 1870                 1875             


Thr Tyr  Leu Pro Thr Leu Pro  Gly Asp Tyr Ser Ile  Leu Val Lys 
    1880                 1885                 1890             


Tyr Asn  Asp Lys His Ile Pro  Gly Ser Pro Phe Thr  Ala Lys Ile 
    1895                 1900                 1905             


Thr Asp  Asp Ser Arg Arg Cys  Ser Gln Val Lys Leu  Gly Ser Ala 
    1910                 1915                 1920             


Ala Asp  Phe Leu Leu Asp Ile  Ser Glu Thr Asp Leu  Ser Ser Leu 
    1925                 1930                 1935             


Thr Ala  Ser Ile Lys Ala Pro  Ser Gly Arg Asp Glu  Pro Cys Leu 
    1940                 1945                 1950             


Leu Lys  Arg Leu Pro Asn Asn  His Ile Gly Ile Ser  Phe Ile Pro 
    1955                 1960                 1965             


Arg Glu  Val Gly Glu His Leu  Val Ser Ile Lys Lys  Asn Gly Asn 
    1970                 1975                 1980             


His Val  Ala Asn Ser Pro Val  Ser Ile Met Val Val  Gln Ser Glu 
    1985                 1990                 1995             


Ile Gly  Asp Ala Arg Arg Ala  Lys Val Tyr Gly Arg  Gly Leu Ser 
    2000                 2005                 2010             


Glu Gly  Arg Thr Phe Glu Met  Ser Asp Phe Ile Val  Asp Thr Arg 
    2015                 2020                 2025             


Asp Ala  Gly Tyr Gly Gly Ile  Ser Leu Ala Val Glu  Gly Pro Ser 
    2030                 2035                 2040             


Lys Val  Asp Ile Gln Thr Glu  Asp Leu Glu Asp Gly  Thr Cys Lys 
    2045                 2050                 2055             


Val Ser  Tyr Phe Pro Thr Val  Pro Gly Val Tyr Ile  Val Ser Thr 
    2060                 2065                 2070             


Lys Phe  Ala Asp Glu His Val  Pro Gly Ser Pro Phe  Thr Val Lys 
    2075                 2080                 2085             


Ile Ser  Gly Glu Gly Arg Val  Lys Glu Ser Ile Thr  Arg Thr Ser 
    2090                 2095                 2100             


Arg Ala  Pro Ser Val Ala Thr  Val Gly Ser Ile Cys  Asp Leu Asn 
    2105                 2110                 2115             


Leu Lys  Ile Pro Glu Ile Asn  Ser Ser Asp Met Ser  Ala His Val 
    2120                 2125                 2130             


Thr Ser  Pro Ser Gly Arg Val  Thr Glu Ala Glu Ile  Val Pro Met 
    2135                 2140                 2145             


Gly Lys  Asn Ser His Cys Val  Arg Phe Val Pro Gln  Glu Met Gly 
    2150                 2155                 2160             


Val His  Thr Val Ser Val Lys  Tyr Arg Gly Gln His  Val Thr Gly 
    2165                 2170                 2175             


Ser Pro  Phe Gln Phe Thr Val  Gly Pro Leu Gly Glu  Gly Gly Ala 
    2180                 2185                 2190             


His Lys  Val Arg Ala Gly Gly  Pro Gly Leu Glu Arg  Gly Glu Ala 
    2195                 2200                 2205             


Gly Val  Pro Ala Glu Phe Ser  Ile Trp Thr Arg Glu  Ala Gly Ala 
    2210                 2215                 2220             


Gly Gly  Leu Ser Ile Ala Val  Glu Gly Pro Ser Lys  Ala Glu Ile 
    2225                 2230                 2235             


Thr Phe  Asp Asp His Lys Asn  Gly Ser Cys Gly Val  Ser Tyr Ile 
    2240                 2245                 2250             


Ala Gln  Glu Pro Gly Asn Tyr  Glu Val Ser Ile Lys  Phe Asn Asp 
    2255                 2260                 2265             


Glu His  Ile Pro Glu Ser Pro  Tyr Leu Val Pro Val  Ile Ala Pro 
    2270                 2275                 2280             


Ser Asp  Asp Ala Arg Arg Leu  Thr Val Met Ser Leu  Gln Glu Ser 
    2285                 2290                 2295             


Gly Leu  Lys Val Asn Gln Pro  Ala Ser Phe Ala Ile  Arg Leu Asn 
    2300                 2305                 2310             


Gly Ala  Lys Gly Lys Ile Asp  Ala Lys Val His Ser  Pro Ser Gly 
    2315                 2320                 2325             


Ala Val  Glu Glu Cys His Val  Ser Glu Leu Glu Pro  Asp Lys Tyr 
    2330                 2335                 2340             


Ala Val  Arg Phe Ile Pro His  Glu Asn Gly Val His  Thr Ile Asp 
    2345                 2350                 2355             


Val Lys  Phe Asn Gly Ser His  Val Val Gly Ser Pro  Phe Lys Val 
    2360                 2365                 2370             


Arg Val  Gly Glu Pro Gly Gln  Ala Gly Asn Pro Ala  Leu Val Ser 
    2375                 2380                 2385             


Ala Tyr  Gly Thr Gly Leu Glu  Gly Gly Thr Thr Gly  Ile Gln Ser 
    2390                 2395                 2400             


Glu Phe  Phe Ile Asn Thr Thr  Arg Ala Gly Pro Gly  Thr Leu Ser 
    2405                 2410                 2415             


Val Thr  Ile Glu Gly Pro Ser  Lys Val Lys Met Asp  Cys Gln Glu 
    2420                 2425                 2430             


Thr Pro  Glu Gly Tyr Lys Val  Met Tyr Thr Pro Met  Ala Pro Gly 
    2435                 2440                 2445             


Asn Tyr  Leu Ile Ser Val Lys  Tyr Gly Gly Pro Asn  His Ile Val 
    2450                 2455                 2460             


Gly Ser  Pro Phe Lys Ala Lys  Val Thr Gly Gln Arg  Leu Val Ser 
    2465                 2470                 2475             


Pro Gly  Ser Ala Asn Glu Thr  Ser Ser Ile Leu Val  Glu Ser Val 
    2480                 2485                 2490             


Thr Arg  Ser Ser Thr Glu Thr  Cys Tyr Ser Ala Ile  Pro Lys Ala 
    2495                 2500                 2505             


Ser Ser  Asp Ala Ser Lys Val  Thr Ser Lys Gly Ala  Gly Leu Ser 
    2510                 2515                 2520             


Lys Ala  Phe Val Gly Gln Lys  Ser Ser Phe Leu Val  Asp Cys Ser 
    2525                 2530                 2535             


Lys Ala  Gly Ser Asn Met Leu  Leu Ile Gly Val His  Gly Pro Thr 
    2540                 2545                 2550             


Thr Pro  Cys Glu Glu Val Ser  Met Lys His Val Gly  Asn Gln Gln 
    2555                 2560                 2565             


Tyr Asn  Val Thr Tyr Val Val  Lys Glu Arg Gly Asp  Tyr Val Leu 
    2570                 2575                 2580             


Ala Val  Lys Trp Gly Glu Glu  His Ile Pro Gly Ser  Pro Phe His 
    2585                 2590                 2595             


Val Thr  Val Pro 
    2600         

<210>  1585
<211>  9416
<212>  DNA
<213>  Homo sapiens

<400>  1585
ccgcagagca gcaccggccg tggctccggt agcagcaagt tcgaaccccg ctcccgctcc     60

gcttcggttc tcgctccttc ggcccttggg cctccaaaca ccagtccccg gcagctcgtt    120

gcgcattgcg ctctccccgc caccaggatg ccggtaaccg agaaggatct agctgaggac    180

gcgccttgga agaagatcca gcagaacacg ttcacacgct ggtgcaacga gcacctcaag    240

tgcgtgaaca aacgcatcgg caacctgcag accgacctga gcgacgggct gcggctcatc    300

gcgctgctcg aggtgctcag ccagaagcgc atgtaccgca agtaccatca gcggcccacc    360

tttcgccaga tgcagctcga gaatgtgtcc gtggcgctcg agttcctgga ccgtgagagc    420

atcaagctcg tgtccatcga tagcaaagcc attgtggatg ggaacctgaa gctcatcttg    480

ggtctggtgt ggacgctgat cctccactac tccatctcca tgcccgtgtg ggaggatgaa    540

ggggatgatg atgccaagaa gcagacgcca aagcagaggc tgctggggtg gattcagaac    600

aagatcccct acttgcccat caccaacttt aaccagaact ggcaagacgg caaagccctg    660

ggagccctgg tagacagctg tgctccaggt ctgtgcccag actgggaatc ctgggacccg    720

cagaagcctg tggataatgc acgagaagcc atgcagcagg cagatgactg gctgggtgtc    780

ccacaggtca tcactcctga agaaatcatt cacccggatg tggacgagca ctcagttatg    840

acttacctgt cccagttccc caaagccaag ctcaagccgg gggctcctct caaacccaaa    900

ctcaacccga agaaagccag ggcctatggc agaggaatcg agcccactgg aaacatggtg    960

aagcagccag ccaagttcac tgtggacacc atcagcgccg ggcaaggaga cgtgatggtg   1020

tttgttgagg acccagaagg gaacaaagag gaggcacaag tgacccctga cagtgacaag   1080

aacaagacat actctgtgga gtatctgccc aaggtcaccg ggctacacaa agtcacagtc   1140

ctctttgcag gacagcacat ctccaagagc ccatttgaag tgagtgttga caaggcccag   1200

ggagatgcca gtaaagtcac tgcaaaaggt ccagggttgg aagctgtagg gaacatcgcc   1260

aataagccca cctactttga catctatacg gcaggagctg gtgtgggtga cattggtgtg   1320

gaggtggaag atccccaggg gaagaacacc gtggagttgc tcgtggaaga caaaggaaac   1380

caggtgtatc gatgtgtgta caaacccatg cagcctggcc ctcacgtggt caagatcttc   1440

tttgctgggg acactattcc taagagtccc ttcgttgtgc aggttgggga agcctgcaat   1500

ccaaatgcct gccgggccag tggccgaggc ctacaaccca aaggcgtccg tatccgggag   1560

accacagatt tcaaggttga caccaaagct gcaggaagtg gggagctcgg tgtaaccatg   1620

aagggtccta agggtctgga ggagctggtg aagcagaaag actttctgga tggggtctac   1680

gcattcgagt attaccccag caccccgggg agatacagca ttgccatcac atggggggga   1740

caccacattc caaagagccc ctttgaagtt caagttggcc ctgaagcggg tatgcagaaa   1800

gtccgtgctt ggggccctgg gctccatggt gggattgtcg ggcggtcagc ggacttcgtg   1860

gtagaatcca ttggctctga agtggggtct ctggggtttg ccattgaagg cccctctcag   1920

gcaaagattg agtacaacga ccagaatgat ggatcgtgtg atgtcaaata ctggcccaag   1980

gagcctggcg aatatgctgt tcacatcatg tgtgacgacg aagacatcaa ggacagcccg   2040

tacatggcct tcatccaccc agccacggga ggctacaacc ctgatctggt tcgagcatac   2100

gggccaggtt tggagaaatc tggatgcatt gtcaacaacc tggccgagtt cactgtggat   2160

cctaaggatg ctggaaaagc tcccttaaag atatttgctc aggatgggga aggccaacgc   2220

attgacatcc agatgaagaa ccggatggac ggcacatatg catgctcata caccccggtg   2280

aaggccatca agcacaccat tgctgtggtc tggggaggcg tgaacatccc gcacagcccc   2340

tacagggtca acatcgggca aggtagccat cctcagaagg tcaaagtgtt tgggccaggt   2400

gtggagagaa gtggtctgaa ggcaaatgaa cctacacact tcacggtgga ctgtactgag   2460

gctggggaag gtgatgtcag tgttggcatt aagtgtgatg cccgggtgtt aagtgaagat   2520

gaggaagacg tggattttga cattattcac aatgccaatg atacgttcac agtcaaatat   2580

gtgcctcctg ctgctgggcg atacactatc aaagttctct ttgcatctca ggaaatcccc   2640

gccagccctt tcagagtcaa agttgaccct tcccacgatg ccagcaaagt gaaggcagaa   2700

ggcccagggc tcagcaaagc aggtgtggaa aatgggaaac cgacccactt cactgtctac   2760

accaaggggg ctgggaaagc cccgctcaac gtgcagttca acagccctct tcctggcgat   2820

gcagtgaagg atttggatat catcgataat tatgactact ctcacacggt taaatataca   2880

cccacccaac agggcaacat gcaggttctg gtgacttacg gtggcgatcc catccctaaa   2940

agccctttca ctgtgggtgt tgctgcaccg ctggatctga gcaagataaa actcaatggg   3000

ctggaaaaca gggtggaagt tgggaaggat caggagttca ccgttgatac caggggggca   3060

ggaggccagg ggaagctgga cgtgacaatc ctcagcccct ctcggaaggt cgtgccatgc   3120

ctagtgacac ctgtgacagg ccgggagaac agcacggcca agttcatccc tcgggaggag   3180

gggctgtatg ctgtagacgt gacctacgat ggacaccctg tgcccgggag cccctacaca   3240

gtggaggcct cgctgccacc agatcccagc aaggtgaagg cccacggtcc cggcctcgaa   3300

ggtggtctcg tgggcaagcc tgccgagttc accatcgata ccaaaggagc tggtactgga   3360

ggtctgggct taacggtgga aggtccgtgc gaggccaaaa tcgagtgctc cgacaatggt   3420

gatgggacct gctccgtctc ttaccttccc acaaaacccg gggagtactt cgtcaacatc   3480

ctctttgaag aagtccacat acctgggtct cccttcaaag ctgacattga aatgcccttt   3540

gacccctcta aagtcgtggc atcggggcca ggtctcgagc acgggaaggt gggtgaagct   3600

ggcctcctta gcgtcgactg ctcggaagcg ggaccggggg ccctgggcct ggaagctgtc   3660

tcggactcgg gaacaaaagc cgaagtcagt attcagaaca acaaagatgg cacctacgcg   3720

gtgacctacg tgcccctgac ggccggcatg tacacgttga ccatgaagta tggtggcgaa   3780

ctcgtgccac acttccccgc ccgggtcaag gtggagcccg ccgtggacac cagcaggatc   3840

aaagtctttg gaccaggaat agaagggaaa gatgtgttcc gggaagctac caccgacttt   3900

acagttgact ctcggccgct gacccaggtt gggggtgacc acatcaaggc ccacattgcc   3960

aacccctcag gggcctccac cgagtgcttt gtcacagaca atgcggatgg gacctaccag   4020

gtggaataca caccctttga gaaaggtctc catgtagtgg aggtgacata tgatgacgtg   4080

cctatcccaa acagtccctt caaggtggct gtcactgaag gctgccagcc atctagggtg   4140

caagcccaag gacctggatt gaaagaggcc tttaccaaca agcccaatgt cttcaccgtg   4200

gttaccagag gcgcaggaat tggtgggctt ggcataactg ttgagggacc atcagagtcg   4260

aagataaatt gcagagacaa caaggatggc agctgcagtg ctgagtacat tcctttcgca   4320

ccgggggatt acgatgttaa tatcacatat ggaggagccc acatccccgg cagccccttc   4380

agggttcctg tgaaggatgt tgtggacccc agcaaggtca agattgccgg ccccgggctg   4440

ggctcaggcg tccgagcccg tgtcctgcag tccttcacgg tggacagcag caaggctggc   4500

ctggctccgc tggaagtgag ggttctgggc ccacgaggct tggtggagcc agtgaacgtg   4560

gtggacaatg gagatggcac acacacagta acctacaccc catctcagga gggaccttac   4620

atggtctcag ttaaatatgc tgatgaagag attcctcgca gtcccttcaa ggtcaaggtc   4680

cttcccacat atgatgccag caaagtgact gccagtggcc ccggccttag ttcctatggt   4740

gtgcctgcca gtctacctgt ggactttgca attgatgccc gagatgccgg ggaaggcctg   4800

cttgctgttc aaataacgga ccaagaagga aaacccaaaa gagccattgt ccatgacaat   4860

aaagatggca cgtatgctgt cacctacatc cccgacaaga ctgggcgcta tatgattgga   4920

gtcacctacg ggggtgacga catcccactt tctccttatc gcatccgagc cacacagacg   4980

ggtgatgcca gcaagtgcct ggccacgggt cctggaatcg cctccactgt gaaaactggc   5040

gaagaagtag gctttgtggt tgatgccaag actgccggga agggtaaagt gacctgcacg   5100

gttctgaccc cagatggcac tgaggccgag gccgatgtca ttgagaatga agatggaacc   5160

tatgacatct tctacacagc tgccaagccg ggcacatatg tgatctatgt gcgcttcggt   5220

ggtgttgata ttcctaacag ccccttcact gtcatggcca cagatgggga agtcacagcc   5280

gtggaggagg caccggtgac cgaagaggcc tatgtcccag tgagtgacat gaacggcctg   5340

ggatttaagc cttttgacct ggtcattccg tttgctgtca ggaaaggaga aatcactgga   5400

gaggtccaca tgccttctgg gaagacagcc acacctgaga ttgtggacaa caaggacggc   5460

acggtcactg ttagatatgc ccccactgag gtcgggctcc atgagatgca catcaaatac   5520

atgggcagcc acatccctga gagcccactc cagttctacg tgaactaccc caacagtgga   5580

agtgtttctg catacggtcc aggcctcgtg tatggagtgg ccaacaaaac tgccaccttc   5640

accatcgtca cagaggatgc aggagaaggt ggtctggact tggctattga gggcccctca   5700

aaagcagaaa tcagctgcat tgacaataaa gatgggacat gcacagtgac ctacctgccg   5760

actctgccag gcgactacag cattctggtc aagtacaatg acaagcacat ccctggcagc   5820

cccttcacag ccaagatcac agatgacagc aggcggtgct cccaggtgaa gttgggctca   5880

gccgctgact tcctgctcga catcagtgag actgacctca gcagcctgac ggccagcatt   5940

aaggccccat ctggccgaga cgagccctgt ctcctgaaga ggctgcccaa caaccacatt   6000

ggcatctcct tcatcccccg ggaagtgggc gaacatctgg tcagcatcaa gaaaaatggc   6060

aaccatgtgg ccaacagccc cgtgtctatc atggtggtcc agtcggagat tggtgacgcc   6120

cgccgagcca aagtctatgg ccgcggcctg tcagaaggcc ggactttcga gatgtctgac   6180

ttcatcgtgg acacaaggga tgcaggttat ggtggcatat ccttggcggt ggaaggcccc   6240

agcaaagtgg acatccagac ggaggacctg gaagatggca cctgcaaagt ctcctacttc   6300

cctaccgtgc ctggggttta tatcgtctcc accaaattcg ctgacgagca cgtgcctggg   6360

agcccattta ccgtgaagat cagtggggag ggaagagtca aagagagcat cacccgcacc   6420

agtcgggccc cgtccgtggc cactgtcggg agcatttgtg acctgaacct gaaaatccca   6480

gaaatcaaca gcagtgatat gtcggcccac gtcaccagcc cctctggccg tgtgactgag   6540

gcagagattg tgcccatggg gaagaactca cactgcgtcc ggtttgtgcc ccaggagatg   6600

ggcgtgcaca cggtcagcgt caagtaccgt gggcagcacg tcaccggcag ccccttccag   6660

ttcaccgtgg ggccacttgg tgaaggaggc gcccacaagg tgcgggcagg aggccctggc   6720

ctggagagag gagaagcggg agtcccagct gagttcagca tttggacccg ggaagcaggc   6780

gctggaggcc tctccatcgc tgttgagggc cccagtaagg ccgagattac attcgatgac   6840

cataaaaatg ggtcgtgcgg tgtatcttat attgcccaag agcctggtaa ctacgaggtg   6900

tccatcaagt tcaatgatga gcacatcccg gaaagcccct acctggtgcc ggtcatcgca   6960

ccctccgacg acgcccgccg cctcactgtt atgagccttc aggaatcggg attaaaagtt   7020

aaccagccag catcctttgc tataaggttg aatggcgcaa aaggcaagat tgatgcaaag   7080

gtgcacagcc cctctggagc cgtggaggag tgccacgtgt ctgagctgga gccagataag   7140

tatgctgttc gcttcatccc tcatgagaat ggtgtccaca ccatcgatgt caagttcaat   7200

gggagccacg tggttggaag ccccttcaaa gtgcgcgttg gggagcctgg acaagcgggg   7260

aaccctgccc tggtgtccgc ctatggcacg ggactcgaag ggggcaccac aggtatccag   7320

tcggaattct ttattaacac cacccgagca ggtccaggga cattatccgt caccatcgaa   7380

ggcccatcca aggttaaaat ggattgccag gaaacacctg aagggtacaa agtcatgtac   7440

acccccatgg ctcctggtaa ctacctgatc agcgtcaaat acggtgggcc caaccacatc   7500

gtgggcagtc ccttcaaggc caaggtgaca ggccagcgtc tagttagccc tggctcagcc   7560

aacgagacct catccatcct ggtggagtca gtgaccaggt cgtctacaga gacctgctat   7620

agcgccattc ccaaggcatc ctcggacgcc agcaaggtga cctctaaggg ggcagggctc   7680

tcaaaggcct ttgtgggcca gaagagttcc ttcctggtgg actgcagcaa agctggctcc   7740

aacatgctgc tgatcggggt ccatgggccc accaccccct gcgaggaggt ctccatgaag   7800

catgtaggca accagcaata caacgtcaca tacgtcgtca aggagagggg cgattatgtg   7860

ctggctgtga agtgggggga ggaacacatc cctggcagcc cttttcatgt cacagtgcct   7920

taaaacagtt ttctcaaatc ctggagagag ttcttgtggt tgcttttgtt gcttgtttgt   7980

aattcatttt atacaaagcc ctccagcctg tttgtggggc tgaaacccca tccctaaaat   8040

attgctgttg taaaatgcct tcagaaataa gtcctagact ggactcttga gggacatatt   8100

ggagaatctt aagaaatgca agcttgttca gggggctgag aagatcctga gtacactagg   8160

tgcaaaccag aactcttggt ggaacagacc agccactgca gcagacagac caggaacaca   8220

atgagactga catttcaaaa aaacaaaact ggctagcctg agctgctggt tcactcttca   8280

gcatttatga aacaaggcta ggggaagatg ggcagagaaa aaggggacac ctagtttggt   8340

tgtcatttgg caaaggagat gacttaaaat ccgcttaatc tcttccagtg tccgtgttaa   8400

tgtatttggc tattagatca ctagcactgc tttaccgctc ctcatcgcca acacccccat   8460

gctctgtggc cttcttacac ttctcagagg gcagagtggc agccgggcac cctacagaaa   8520

ctcagagggc agagtggcag ccaggcccac atgtctctca agtacctgtc ccctcgctct   8580

ggtgattatt tcttgcagaa tcaccacacg agaccatccc ggcagtcatg gttttgcttt   8640

agttttccaa gtccgtttca gtcccttcct tggtctgaag aaattctgca gtggcgagca   8700

gtttcccact tgccaaagat cccttttaac caacactagc ccttgttttt aacacacgct   8760

ccagcccttc atcagcctgg gcagtcttac caaaatgttt aaagtgatct cagaggggcc   8820

catggattaa cgccctcatc ccaaggtccg tcccatgaca taacactcca cacccgcccc   8880

agccaacttc atgggtcact ttttctggaa aataatgatc tgtacagaca ggacagaatg   8940

aaactcctgc gggtctttgg cctgaaagtt gggaatggtt gggggagaga agggcagcag   9000

cttattggtg gtcttttcac cattggcaga aacagtgaga gctgtgtggt gcagaaatcc   9060

agaaatgagg tgtagggaat tttgcctgcc ttcctgcaga cctgagctgg ctttggaatg   9120

aggttaaagt gtcagggacg ttgcctgagc ccaaatgtgt agtgtggtct gggcaggcag   9180

acctttaggt tttgctgctt agtcctgagg aagtggccac tcttgtggca ggtgtagtat   9240

ctggggcgag tgttgggggt aaaagcccac cctacagaaa gtggaacagc ccggagcctg   9300

atgtgaaagg accacgggtg ttgtaagctg ggacacggaa gccaaactgg aatcaaacgc   9360

cgactgtaaa ttgtatctta taacttatta aataaaacat ttgctccgta aagttg       9416


<210>  1586
<211>  2591
<212>  PRT
<213>  Homo sapiens

<400>  1586


Met Pro Val Thr Glu Lys Asp Leu Ala Glu Asp Ala Pro Trp Lys Lys 
1               5                   10                  15      


Ile Gln Gln Asn Thr Phe Thr Arg Trp Cys Asn Glu His Leu Lys Cys 
            20                  25                  30          


Val Asn Lys Arg Ile Gly Asn Leu Gln Thr Asp Leu Ser Asp Gly Leu 
        35                  40                  45              


Arg Leu Ile Ala Leu Leu Glu Val Leu Ser Gln Lys Arg Met Tyr Arg 
    50                  55                  60                  


Lys Tyr His Gln Arg Pro Thr Phe Arg Gln Met Gln Leu Glu Asn Val 
65                  70                  75                  80  


Ser Val Ala Leu Glu Phe Leu Asp Arg Glu Ser Ile Lys Leu Val Ser 
                85                  90                  95      


Ile Asp Ser Lys Ala Ile Val Asp Gly Asn Leu Lys Leu Ile Leu Gly 
            100                 105                 110         


Leu Val Trp Thr Leu Ile Leu His Tyr Ser Ile Ser Met Pro Val Trp 
        115                 120                 125             


Glu Asp Glu Gly Asp Asp Asp Ala Lys Lys Gln Thr Pro Lys Gln Arg 
    130                 135                 140                 


Leu Leu Gly Trp Ile Gln Asn Lys Ile Pro Tyr Leu Pro Ile Thr Asn 
145                 150                 155                 160 


Phe Asn Gln Asn Trp Gln Asp Gly Lys Ala Leu Gly Ala Leu Val Asp 
                165                 170                 175     


Ser Cys Ala Pro Gly Leu Cys Pro Asp Trp Glu Ser Trp Asp Pro Gln 
            180                 185                 190         


Lys Pro Val Asp Asn Ala Arg Glu Ala Met Gln Gln Ala Asp Asp Trp 
        195                 200                 205             


Leu Gly Val Pro Gln Val Ile Thr Pro Glu Glu Ile Ile His Pro Asp 
    210                 215                 220                 


Val Asp Glu His Ser Val Met Thr Tyr Leu Ser Gln Phe Pro Lys Ala 
225                 230                 235                 240 


Lys Leu Lys Pro Gly Ala Pro Leu Lys Pro Lys Leu Asn Pro Lys Lys 
                245                 250                 255     


Ala Arg Ala Tyr Gly Arg Gly Ile Glu Pro Thr Gly Asn Met Val Lys 
            260                 265                 270         


Gln Pro Ala Lys Phe Thr Val Asp Thr Ile Ser Ala Gly Gln Gly Asp 
        275                 280                 285             


Val Met Val Phe Val Glu Asp Pro Glu Gly Asn Lys Glu Glu Ala Gln 
    290                 295                 300                 


Val Thr Pro Asp Ser Asp Lys Asn Lys Thr Tyr Ser Val Glu Tyr Leu 
305                 310                 315                 320 


Pro Lys Val Thr Gly Leu His Lys Val Thr Val Leu Phe Ala Gly Gln 
                325                 330                 335     


His Ile Ser Lys Ser Pro Phe Glu Val Ser Val Asp Lys Ala Gln Gly 
            340                 345                 350         


Asp Ala Ser Lys Val Thr Ala Lys Gly Pro Gly Leu Glu Ala Val Gly 
        355                 360                 365             


Asn Ile Ala Asn Lys Pro Thr Tyr Phe Asp Ile Tyr Thr Ala Gly Ala 
    370                 375                 380                 


Gly Val Gly Asp Ile Gly Val Glu Val Glu Asp Pro Gln Gly Lys Asn 
385                 390                 395                 400 


Thr Val Glu Leu Leu Val Glu Asp Lys Gly Asn Gln Val Tyr Arg Cys 
                405                 410                 415     


Val Tyr Lys Pro Met Gln Pro Gly Pro His Val Val Lys Ile Phe Phe 
            420                 425                 430         


Ala Gly Asp Thr Ile Pro Lys Ser Pro Phe Val Val Gln Val Gly Glu 
        435                 440                 445             


Ala Cys Asn Pro Asn Ala Cys Arg Ala Ser Gly Arg Gly Leu Gln Pro 
    450                 455                 460                 


Lys Gly Val Arg Ile Arg Glu Thr Thr Asp Phe Lys Val Asp Thr Lys 
465                 470                 475                 480 


Ala Ala Gly Ser Gly Glu Leu Gly Val Thr Met Lys Gly Pro Lys Gly 
                485                 490                 495     


Leu Glu Glu Leu Val Lys Gln Lys Asp Phe Leu Asp Gly Val Tyr Ala 
            500                 505                 510         


Phe Glu Tyr Tyr Pro Ser Thr Pro Gly Arg Tyr Ser Ile Ala Ile Thr 
        515                 520                 525             


Trp Gly Gly His His Ile Pro Lys Ser Pro Phe Glu Val Gln Val Gly 
    530                 535                 540                 


Pro Glu Ala Gly Met Gln Lys Val Arg Ala Trp Gly Pro Gly Leu His 
545                 550                 555                 560 


Gly Gly Ile Val Gly Arg Ser Ala Asp Phe Val Val Glu Ser Ile Gly 
                565                 570                 575     


Ser Glu Val Gly Ser Leu Gly Phe Ala Ile Glu Gly Pro Ser Gln Ala 
            580                 585                 590         


Lys Ile Glu Tyr Asn Asp Gln Asn Asp Gly Ser Cys Asp Val Lys Tyr 
        595                 600                 605             


Trp Pro Lys Glu Pro Gly Glu Tyr Ala Val His Ile Met Cys Asp Asp 
    610                 615                 620                 


Glu Asp Ile Lys Asp Ser Pro Tyr Met Ala Phe Ile His Pro Ala Thr 
625                 630                 635                 640 


Gly Gly Tyr Asn Pro Asp Leu Val Arg Ala Tyr Gly Pro Gly Leu Glu 
                645                 650                 655     


Lys Ser Gly Cys Ile Val Asn Asn Leu Ala Glu Phe Thr Val Asp Pro 
            660                 665                 670         


Lys Asp Ala Gly Lys Ala Pro Leu Lys Ile Phe Ala Gln Asp Gly Glu 
        675                 680                 685             


Gly Gln Arg Ile Asp Ile Gln Met Lys Asn Arg Met Asp Gly Thr Tyr 
    690                 695                 700                 


Ala Cys Ser Tyr Thr Pro Val Lys Ala Ile Lys His Thr Ile Ala Val 
705                 710                 715                 720 


Val Trp Gly Gly Val Asn Ile Pro His Ser Pro Tyr Arg Val Asn Ile 
                725                 730                 735     


Gly Gln Gly Ser His Pro Gln Lys Val Lys Val Phe Gly Pro Gly Val 
            740                 745                 750         


Glu Arg Ser Gly Leu Lys Ala Asn Glu Pro Thr His Phe Thr Val Asp 
        755                 760                 765             


Cys Thr Glu Ala Gly Glu Gly Asp Val Ser Val Gly Ile Lys Cys Asp 
    770                 775                 780                 


Ala Arg Val Leu Ser Glu Asp Glu Glu Asp Val Asp Phe Asp Ile Ile 
785                 790                 795                 800 


His Asn Ala Asn Asp Thr Phe Thr Val Lys Tyr Val Pro Pro Ala Ala 
                805                 810                 815     


Gly Arg Tyr Thr Ile Lys Val Leu Phe Ala Ser Gln Glu Ile Pro Ala 
            820                 825                 830         


Ser Pro Phe Arg Val Lys Val Asp Pro Ser His Asp Ala Ser Lys Val 
        835                 840                 845             


Lys Ala Glu Gly Pro Gly Leu Ser Lys Ala Gly Val Glu Asn Gly Lys 
    850                 855                 860                 


Pro Thr His Phe Thr Val Tyr Thr Lys Gly Ala Gly Lys Ala Pro Leu 
865                 870                 875                 880 


Asn Val Gln Phe Asn Ser Pro Leu Pro Gly Asp Ala Val Lys Asp Leu 
                885                 890                 895     


Asp Ile Ile Asp Asn Tyr Asp Tyr Ser His Thr Val Lys Tyr Thr Pro 
            900                 905                 910         


Thr Gln Gln Gly Asn Met Gln Val Leu Val Thr Tyr Gly Gly Asp Pro 
        915                 920                 925             


Ile Pro Lys Ser Pro Phe Thr Val Gly Val Ala Ala Pro Leu Asp Leu 
    930                 935                 940                 


Ser Lys Ile Lys Leu Asn Gly Leu Glu Asn Arg Val Glu Val Gly Lys 
945                 950                 955                 960 


Asp Gln Glu Phe Thr Val Asp Thr Arg Gly Ala Gly Gly Gln Gly Lys 
                965                 970                 975     


Leu Asp Val Thr Ile Leu Ser Pro Ser Arg Lys Val Val Pro Cys Leu 
            980                 985                 990         


Val Thr Pro Val Thr Gly Arg Glu  Asn Ser Thr Ala Lys  Phe Ile Pro 
        995                 1000                 1005             


Arg Glu  Glu Gly Leu Tyr Ala  Val Asp Val Thr Tyr  Asp Gly His 
    1010                 1015                 1020             


Pro Val  Pro Gly Ser Pro Tyr  Thr Val Glu Ala Ser  Leu Pro Pro 
    1025                 1030                 1035             


Asp Pro  Ser Lys Val Lys Ala  His Gly Pro Gly Leu  Glu Gly Gly 
    1040                 1045                 1050             


Leu Val  Gly Lys Pro Ala Glu  Phe Thr Ile Asp Thr  Lys Gly Ala 
    1055                 1060                 1065             


Gly Thr  Gly Gly Leu Gly Leu  Thr Val Glu Gly Pro  Cys Glu Ala 
    1070                 1075                 1080             


Lys Ile  Glu Cys Ser Asp Asn  Gly Asp Gly Thr Cys  Ser Val Ser 
    1085                 1090                 1095             


Tyr Leu  Pro Thr Lys Pro Gly  Glu Tyr Phe Val Asn  Ile Leu Phe 
    1100                 1105                 1110             


Glu Glu  Val His Ile Pro Gly  Ser Pro Phe Lys Ala  Asp Ile Glu 
    1115                 1120                 1125             


Met Pro  Phe Asp Pro Ser Lys  Val Val Ala Ser Gly  Pro Gly Leu 
    1130                 1135                 1140             


Glu His  Gly Lys Val Gly Glu  Ala Gly Leu Leu Ser  Val Asp Cys 
    1145                 1150                 1155             


Ser Glu  Ala Gly Pro Gly Ala  Leu Gly Leu Glu Ala  Val Ser Asp 
    1160                 1165                 1170             


Ser Gly  Thr Lys Ala Glu Val  Ser Ile Gln Asn Asn  Lys Asp Gly 
    1175                 1180                 1185             


Thr Tyr  Ala Val Thr Tyr Val  Pro Leu Thr Ala Gly  Met Tyr Thr 
    1190                 1195                 1200             


Leu Thr  Met Lys Tyr Gly Gly  Glu Leu Val Pro His  Phe Pro Ala 
    1205                 1210                 1215             


Arg Val  Lys Val Glu Pro Ala  Val Asp Thr Ser Arg  Ile Lys Val 
    1220                 1225                 1230             


Phe Gly  Pro Gly Ile Glu Gly  Lys Asp Val Phe Arg  Glu Ala Thr 
    1235                 1240                 1245             


Thr Asp  Phe Thr Val Asp Ser  Arg Pro Leu Thr Gln  Val Gly Gly 
    1250                 1255                 1260             


Asp His  Ile Lys Ala His Ile  Ala Asn Pro Ser Gly  Ala Ser Thr 
    1265                 1270                 1275             


Glu Cys  Phe Val Thr Asp Asn  Ala Asp Gly Thr Tyr  Gln Val Glu 
    1280                 1285                 1290             


Tyr Thr  Pro Phe Glu Lys Gly  Leu His Val Val Glu  Val Thr Tyr 
    1295                 1300                 1305             


Asp Asp  Val Pro Ile Pro Asn  Ser Pro Phe Lys Val  Ala Val Thr 
    1310                 1315                 1320             


Glu Gly  Cys Gln Pro Ser Arg  Val Gln Ala Gln Gly  Pro Gly Leu 
    1325                 1330                 1335             


Lys Glu  Ala Phe Thr Asn Lys  Pro Asn Val Phe Thr  Val Val Thr 
    1340                 1345                 1350             


Arg Gly  Ala Gly Ile Gly Gly  Leu Gly Ile Thr Val  Glu Gly Pro 
    1355                 1360                 1365             


Ser Glu  Ser Lys Ile Asn Cys  Arg Asp Asn Lys Asp  Gly Ser Cys 
    1370                 1375                 1380             


Ser Ala  Glu Tyr Ile Pro Phe  Ala Pro Gly Asp Tyr  Asp Val Asn 
    1385                 1390                 1395             


Ile Thr  Tyr Gly Gly Ala His  Ile Pro Gly Ser Pro  Phe Arg Val 
    1400                 1405                 1410             


Pro Val  Lys Asp Val Val Asp  Pro Ser Lys Val Lys  Ile Ala Gly 
    1415                 1420                 1425             


Pro Gly  Leu Gly Ser Gly Val  Arg Ala Arg Val Leu  Gln Ser Phe 
    1430                 1435                 1440             


Thr Val  Asp Ser Ser Lys Ala  Gly Leu Ala Pro Leu  Glu Val Arg 
    1445                 1450                 1455             


Val Leu  Gly Pro Arg Gly Leu  Val Glu Pro Val Asn  Val Val Asp 
    1460                 1465                 1470             


Asn Gly  Asp Gly Thr His Thr  Val Thr Tyr Thr Pro  Ser Gln Glu 
    1475                 1480                 1485             


Gly Pro  Tyr Met Val Ser Val  Lys Tyr Ala Asp Glu  Glu Ile Pro 
    1490                 1495                 1500             


Arg Ser  Pro Phe Lys Val Lys  Val Leu Pro Thr Tyr  Asp Ala Ser 
    1505                 1510                 1515             


Lys Val  Thr Ala Ser Gly Pro  Gly Leu Ser Ser Tyr  Gly Val Pro 
    1520                 1525                 1530             


Ala Ser  Leu Pro Val Asp Phe  Ala Ile Asp Ala Arg  Asp Ala Gly 
    1535                 1540                 1545             


Glu Gly  Leu Leu Ala Val Gln  Ile Thr Asp Gln Glu  Gly Lys Pro 
    1550                 1555                 1560             


Lys Arg  Ala Ile Val His Asp  Asn Lys Asp Gly Thr  Tyr Ala Val 
    1565                 1570                 1575             


Thr Tyr  Ile Pro Asp Lys Thr  Gly Arg Tyr Met Ile  Gly Val Thr 
    1580                 1585                 1590             


Tyr Gly  Gly Asp Asp Ile Pro  Leu Ser Pro Tyr Arg  Ile Arg Ala 
    1595                 1600                 1605             


Thr Gln  Thr Gly Asp Ala Ser  Lys Cys Leu Ala Thr  Gly Pro Gly 
    1610                 1615                 1620             


Ile Ala  Ser Thr Val Lys Thr  Gly Glu Glu Val Gly  Phe Val Val 
    1625                 1630                 1635             


Asp Ala  Lys Thr Ala Gly Lys  Gly Lys Val Thr Cys  Thr Val Leu 
    1640                 1645                 1650             


Thr Pro  Asp Gly Thr Glu Ala  Glu Ala Asp Val Ile  Glu Asn Glu 
    1655                 1660                 1665             


Asp Gly  Thr Tyr Asp Ile Phe  Tyr Thr Ala Ala Lys  Pro Gly Thr 
    1670                 1675                 1680             


Tyr Val  Ile Tyr Val Arg Phe  Gly Gly Val Asp Ile  Pro Asn Ser 
    1685                 1690                 1695             


Pro Phe  Thr Val Met Ala Thr  Asp Gly Glu Val Thr  Ala Val Glu 
    1700                 1705                 1710             


Glu Ala  Pro Val Thr Glu Glu  Ala Tyr Val Pro Val  Ser Asp Met 
    1715                 1720                 1725             


Asn Gly  Leu Gly Phe Lys Pro  Phe Asp Leu Val Ile  Pro Phe Ala 
    1730                 1735                 1740             


Val Arg  Lys Gly Glu Ile Thr  Gly Glu Val His Met  Pro Ser Gly 
    1745                 1750                 1755             


Lys Thr  Ala Thr Pro Glu Ile  Val Asp Asn Lys Asp  Gly Thr Val 
    1760                 1765                 1770             


Thr Val  Arg Tyr Ala Pro Thr  Glu Val Gly Leu His  Glu Met His 
    1775                 1780                 1785             


Ile Lys  Tyr Met Gly Ser His  Ile Pro Glu Ser Pro  Leu Gln Phe 
    1790                 1795                 1800             


Tyr Val  Asn Tyr Pro Asn Ser  Gly Ser Val Ser Ala  Tyr Gly Pro 
    1805                 1810                 1815             


Gly Leu  Val Tyr Gly Val Ala  Asn Lys Thr Ala Thr  Phe Thr Ile 
    1820                 1825                 1830             


Val Thr  Glu Asp Ala Gly Glu  Gly Gly Leu Asp Leu  Ala Ile Glu 
    1835                 1840                 1845             


Gly Pro  Ser Lys Ala Glu Ile  Ser Cys Ile Asp Asn  Lys Asp Gly 
    1850                 1855                 1860             


Thr Cys  Thr Val Thr Tyr Leu  Pro Thr Leu Pro Gly  Asp Tyr Ser 
    1865                 1870                 1875             


Ile Leu  Val Lys Tyr Asn Asp  Lys His Ile Pro Gly  Ser Pro Phe 
    1880                 1885                 1890             


Thr Ala  Lys Ile Thr Asp Asp  Ser Arg Arg Cys Ser  Gln Val Lys 
    1895                 1900                 1905             


Leu Gly  Ser Ala Ala Asp Phe  Leu Leu Asp Ile Ser  Glu Thr Asp 
    1910                 1915                 1920             


Leu Ser  Ser Leu Thr Ala Ser  Ile Lys Ala Pro Ser  Gly Arg Asp 
    1925                 1930                 1935             


Glu Pro  Cys Leu Leu Lys Arg  Leu Pro Asn Asn His  Ile Gly Ile 
    1940                 1945                 1950             


Ser Phe  Ile Pro Arg Glu Val  Gly Glu His Leu Val  Ser Ile Lys 
    1955                 1960                 1965             


Lys Asn  Gly Asn His Val Ala  Asn Ser Pro Val Ser  Ile Met Val 
    1970                 1975                 1980             


Val Gln  Ser Glu Ile Gly Asp  Ala Arg Arg Ala Lys  Val Tyr Gly 
    1985                 1990                 1995             


Arg Gly  Leu Ser Glu Gly Arg  Thr Phe Glu Met Ser  Asp Phe Ile 
    2000                 2005                 2010             


Val Asp  Thr Arg Asp Ala Gly  Tyr Gly Gly Ile Ser  Leu Ala Val 
    2015                 2020                 2025             


Glu Gly  Pro Ser Lys Val Asp  Ile Gln Thr Glu Asp  Leu Glu Asp 
    2030                 2035                 2040             


Gly Thr  Cys Lys Val Ser Tyr  Phe Pro Thr Val Pro  Gly Val Tyr 
    2045                 2050                 2055             


Ile Val  Ser Thr Lys Phe Ala  Asp Glu His Val Pro  Gly Ser Pro 
    2060                 2065                 2070             


Phe Thr  Val Lys Ile Ser Gly  Glu Gly Arg Val Lys  Glu Ser Ile 
    2075                 2080                 2085             


Thr Arg  Thr Ser Arg Ala Pro  Ser Val Ala Thr Val  Gly Ser Ile 
    2090                 2095                 2100             


Cys Asp  Leu Asn Leu Lys Ile  Pro Glu Ile Asn Ser  Ser Asp Met 
    2105                 2110                 2115             


Ser Ala  His Val Thr Ser Pro  Ser Gly Arg Val Thr  Glu Ala Glu 
    2120                 2125                 2130             


Ile Val  Pro Met Gly Lys Asn  Ser His Cys Val Arg  Phe Val Pro 
    2135                 2140                 2145             


Gln Glu  Met Gly Val His Thr  Val Ser Val Lys Tyr  Arg Gly Gln 
    2150                 2155                 2160             


His Val  Thr Gly Ser Pro Phe  Gln Phe Thr Val Gly  Pro Leu Gly 
    2165                 2170                 2175             


Glu Gly  Gly Ala His Lys Val  Arg Ala Gly Gly Pro  Gly Leu Glu 
    2180                 2185                 2190             


Arg Gly  Glu Ala Gly Val Pro  Ala Glu Phe Ser Ile  Trp Thr Arg 
    2195                 2200                 2205             


Glu Ala  Gly Ala Gly Gly Leu  Ser Ile Ala Val Glu  Gly Pro Ser 
    2210                 2215                 2220             


Lys Ala  Glu Ile Thr Phe Asp  Asp His Lys Asn Gly  Ser Cys Gly 
    2225                 2230                 2235             


Val Ser  Tyr Ile Ala Gln Glu  Pro Gly Asn Tyr Glu  Val Ser Ile 
    2240                 2245                 2250             


Lys Phe  Asn Asp Glu His Ile  Pro Glu Ser Pro Tyr  Leu Val Pro 
    2255                 2260                 2265             


Val Ile  Ala Pro Ser Asp Asp  Ala Arg Arg Leu Thr  Val Met Ser 
    2270                 2275                 2280             


Leu Gln  Glu Ser Gly Leu Lys  Val Asn Gln Pro Ala  Ser Phe Ala 
    2285                 2290                 2295             


Ile Arg  Leu Asn Gly Ala Lys  Gly Lys Ile Asp Ala  Lys Val His 
    2300                 2305                 2310             


Ser Pro  Ser Gly Ala Val Glu  Glu Cys His Val Ser  Glu Leu Glu 
    2315                 2320                 2325             


Pro Asp  Lys Tyr Ala Val Arg  Phe Ile Pro His Glu  Asn Gly Val 
    2330                 2335                 2340             


His Thr  Ile Asp Val Lys Phe  Asn Gly Ser His Val  Val Gly Ser 
    2345                 2350                 2355             


Pro Phe  Lys Val Arg Val Gly  Glu Pro Gly Gln Ala  Gly Asn Pro 
    2360                 2365                 2370             


Ala Leu  Val Ser Ala Tyr Gly  Thr Gly Leu Glu Gly  Gly Thr Thr 
    2375                 2380                 2385             


Gly Ile  Gln Ser Glu Phe Phe  Ile Asn Thr Thr Arg  Ala Gly Pro 
    2390                 2395                 2400             


Gly Thr  Leu Ser Val Thr Ile  Glu Gly Pro Ser Lys  Val Lys Met 
    2405                 2410                 2415             


Asp Cys  Gln Glu Thr Pro Glu  Gly Tyr Lys Val Met  Tyr Thr Pro 
    2420                 2425                 2430             


Met Ala  Pro Gly Asn Tyr Leu  Ile Ser Val Lys Tyr  Gly Gly Pro 
    2435                 2440                 2445             


Asn His  Ile Val Gly Ser Pro  Phe Lys Ala Lys Val  Thr Gly Gln 
    2450                 2455                 2460             


Arg Leu  Val Ser Pro Gly Ser  Ala Asn Glu Thr Ser  Ser Ile Leu 
    2465                 2470                 2475             


Val Glu  Ser Val Thr Arg Ser  Ser Thr Glu Thr Cys  Tyr Ser Ala 
    2480                 2485                 2490             


Ile Pro  Lys Ala Ser Ser Asp  Ala Ser Lys Val Thr  Ser Lys Gly 
    2495                 2500                 2505             


Ala Gly  Leu Ser Lys Ala Phe  Val Gly Gln Lys Ser  Ser Phe Leu 
    2510                 2515                 2520             


Val Asp  Cys Ser Lys Ala Gly  Ser Asn Met Leu Leu  Ile Gly Val 
    2525                 2530                 2535             


His Gly  Pro Thr Thr Pro Cys  Glu Glu Val Ser Met  Lys His Val 
    2540                 2545                 2550             


Gly Asn  Gln Gln Tyr Asn Val  Thr Tyr Val Val Lys  Glu Arg Gly 
    2555                 2560                 2565             


Asp Tyr  Val Leu Ala Val Lys  Trp Gly Glu Glu His  Ile Pro Gly 
    2570                 2575                 2580             


Ser Pro  Phe His Val Thr Val  Pro 
    2585                 2590     

<210>  1587
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  1587
cccaggagag ggggctggaa gagagcgagc tgccattgta ttttggttgc tgtggatcta     60

aggagaagag atgtttagga gtctttccct ggcatggttc ctcctgcctt cacccatcac    120

tcttttcctc gagggattcc ctgtggggtg cacagcccca gggtgggcca gactgagctc    180

acaggagcat gggctgtgtt tcagatgtgg cctcagaatc cttctcaaca cagtgtacta    240

gcaccacttg gtgctcctga tctactgtat catctcttga aaaactacta acatgaaaag    300

acctgccaag tcaactttat attaactgaa cccttgacac agtgatggat aaaaattaat    360

tcaaacagc                                                            369


<210>  1588
<211>  65
<212>  PRT
<213>  Homo sapiens

<400>  1588


Met Val Pro Pro Ala Phe Thr His His Ser Phe Pro Arg Gly Ile Pro 
1               5                   10                  15      


Cys Gly Val His Ser Pro Arg Val Gly Gln Thr Glu Leu Thr Gly Ala 
            20                  25                  30          


Trp Ala Val Phe Gln Met Trp Pro Gln Asn Pro Ser Gln His Ser Val 
        35                  40                  45              


Leu Ala Pro Leu Gly Ala Pro Asp Leu Leu Tyr His Leu Leu Lys Asn 
    50                  55                  60                  


Tyr 
65  

<210>  1589
<211>  8992
<212>  DNA
<213>  Homo sapiens

<400>  1589
actctagtcc tttacctcat gtgcttacaa aggcttttaa gataattcta ggtttgtgcc     60

tttgagcaag tggatttttg aatcacacag gatgctattc tagacttttt agatatatcc    120

aggaatagag taaaaaataa aatccctcct gcataaaggc accaggcttt ttccaagctt    180

tgtttatttt ttaacaccac ttcttcaagg aatggataat ccccatcttc atgcaagaac    240

atagcacccg gaggagaagt ctcagtctgt gcccagactg ggaatcctgg gacccgcaga    300

agcctgtgga taatgcacga gaagccatgc agcaggcaga tgactggctg ggtgtcccac    360

aggtcatcac tcctgaagaa atcattcacc cggatgtgga cgagcactca gttatgactt    420

acctgtccca gttccccaaa gccaagctca agccgggggc tcctctcaaa cccaaactca    480

acccgaagaa agccagggcc tatggcagag gaatcgagcc cactggaaac atggtgaagc    540

agccagccaa gttcactgtg gacaccatca gcgccgggca aggagacgtg atggtgtttg    600

ttgaggaccc agaagggaac aaagaggagg cacaagtgac ccctgacagt gacaagaaca    660

agacatactc tgtggagtat ctgcccaagg tcaccgggct acacaaagtc acagtcctct    720

ttgcaggaca gcacatctcc aagagcccat ttgaagtgag tgttgacaag gcccagggag    780

atgccagtaa agtcactgca aaaggtccag ggttggaagc tgtagggaac atcgccaata    840

agcccaccta ctttgacatc tatacggcag gagctggtgt gggtgacatt ggtgtggagg    900

tggaagatcc ccaggggaag aacaccgtgg agttgctcgt ggaagacaaa ggaaaccagg    960

tgtatcgatg tgtgtacaaa cccatgcagc ctggccctca cgtggtcaag atcttctttg   1020

ctggggacac tattcctaag agtcccttcg ttgtgcaggt tggggaagcc tgcaatccaa   1080

atgcctgccg ggccagtggc cgaggcctac aacccaaagg cgtccgtatc cgggagacca   1140

cagatttcaa ggttgacacc aaagctgcag gaagtgggga gctcggtgta accatgaagg   1200

gtcctaaggg tctggaggag ctggtgaagc agaaagactt tctggatggg gtctacgcat   1260

tcgagtatta ccccagcacc ccggggagat acagcattgc catcacatgg gggggacacc   1320

acattccaaa gagccccttt gaagttcaag ttggccctga agcgggtatg cagaaagtcc   1380

gtgcttgggg ccctgggctc catggtggga ttgtcgggcg gtcagcggac ttcgtggtag   1440

aatccattgg ctctgaagtg gggtctctgg ggtttgccat tgaaggcccc tctcaggcaa   1500

agattgagta caacgaccag aatgatggat cgtgtgatgt caaatactgg cccaaggagc   1560

ctggcgaata tgctgttcac atcatgtgtg acgacgaaga catcaaggac agcccgtaca   1620

tggccttcat ccacccagcc acgggaggct acaaccctga tctggttcga gcatacgggc   1680

caggtttgga gaaatctgga tgcattgtca acaacctggc cgagttcact gtggatccta   1740

aggatgctgg aaaagctccc ttaaagatat ttgctcagga tggggaaggc caacgcattg   1800

acatccagat gaagaaccgg atggacggca catatgcatg ctcatacacc ccggtgaagg   1860

ccatcaagca caccattgct gtggtctggg gaggcgtgaa catcccgcac agcccctaca   1920

gggtcaacat cgggcaaggt agccatcctc agaaggtcaa agtgtttggg ccaggtgtgg   1980

agagaagtgg tctgaaggca aatgaaccta cacacttcac ggtggactgt actgaggctg   2040

gggaaggtga tgtcagtgtt ggcattaagt gtgatgcccg ggtgttaagt gaagatgagg   2100

aagacgtgga ttttgacatt attcacaatg ccaatgatac gttcacagtc aaatatgtgc   2160

ctcctgctgc tgggcgatac actatcaaag ttctctttgc atctcaggaa atccccgcca   2220

gccctttcag agtcaaagtt gacccttccc acgatgccag caaagtgaag gcagaaggcc   2280

cagggctcag caaagcaggt gtggaaaatg ggaaaccgac ccacttcact gtctacacca   2340

agggggctgg gaaagccccg ctcaacgtgc agttcaacag ccctcttcct ggcgatgcag   2400

tgaaggattt ggatatcatc gataattatg actactctca cacggttaaa tatacaccca   2460

cccaacaggg caacatgcag gttctggtga cttacggtgg cgatcccatc cctaaaagcc   2520

ctttcactgt gggtgttgct gcaccgctgg atctgagcaa gataaaactc aatgggctgg   2580

aaaacagggt ggaagttggg aaggatcagg agttcaccgt tgataccagg ggggcaggag   2640

gccaggggaa gctggacgtg acaatcctca gcccctctcg gaaggtcgtg ccatgcctag   2700

tgacacctgt gacaggccgg gagaacagca cggccaagtt catccctcgg gaggaggggc   2760

tgtatgctgt agacgtgacc tacgatggac accctgtgcc cgggagcccc tacacagtgg   2820

aggcctcgct gccaccagat cccagcaagg tgaaggccca cggtcccggc ctcgaaggtg   2880

gtctcgtggg caagcctgcc gagttcacca tcgataccaa aggagctggt actggaggtc   2940

tgggcttaac ggtggaaggt ccgtgcgagg ccaaaatcga gtgctccgac aatggtgatg   3000

ggacctgctc cgtctcttac cttcccacaa aacccgggga gtacttcgtc aacatcctct   3060

ttgaagaagt ccacatacct gggtctccct tcaaagctga cattgaaatg ccctttgacc   3120

cctctaaagt cgtggcatcg gggccaggtc tcgagcacgg gaaggtgggt gaagctggcc   3180

tccttagcgt cgactgctcg gaagcgggac cgggggccct gggcctggaa gctgtctcgg   3240

actcgggaac aaaagccgaa gtcagtattc agaacaacaa agatggcacc tacgcggtga   3300

cctacgtgcc cctgacggcc ggcatgtaca cgttgaccat gaagtatggt ggcgaactcg   3360

tgccacactt ccccgcccgg gtcaaggtgg agcccgccgt ggacaccagc aggatcaaag   3420

tctttggacc aggaatagaa gggaaagatg tgttccggga agctaccacc gactttacag   3480

ttgactctcg gccgctgacc caggttgggg gtgaccacat caaggcccac attgccaacc   3540

cctcaggggc ctccaccgag tgctttgtca cagacaatgc ggatgggacc taccaggtgg   3600

aatacacacc ctttgagaaa ggtctccatg tagtggaggt gacatatgat gacgtgccta   3660

tcccaaacag tcccttcaag gtggctgtca ctgaaggctg ccagccatct agggtgcaag   3720

cccaaggacc tggattgaaa gaggccttta ccaacaagcc caatgtcttc accgtggtta   3780

ccagaggcgc aggaattggt gggcttggca taactgttga gggaccatca gagtcgaaga   3840

taaattgcag agacaacaag gatggcagct gcagtgctga gtacattcct ttcgcaccgg   3900

gggattacga tgttaatatc acatatggag gagcccacat ccccggcagc cccttcaggg   3960

ttcctgtgaa ggatgttgtg gaccccagca aggtcaagat tgccggcccc gggctgggct   4020

caggcgtccg agcccgtgtc ctgcagtcct tcacggtgga cagcagcaag gctggcctgg   4080

ctccgctgga agtgagggtt ctgggcccac gaggcttggt ggagccagtg aacgtggtgg   4140

acaatggaga tggcacacac acagtaacct acaccccatc tcaggaggga ccttacatgg   4200

tctcagttaa atatgctgat gaagagattc ctcgcagtcc cttcaaggtc aaggtccttc   4260

ccacatatga tgccagcaaa gtgactgcca gtggccccgg ccttagttcc tatggtgtgc   4320

ctgccagtct acctgtggac tttgcaattg atgcccgaga tgccggggaa ggcctgcttg   4380

ctgttcaaat aacggaccaa gaaggaaaac ccaaaagagc cattgtccat gacaataaag   4440

atggcacgta tgctgtcacc tacatccccg acaagactgg gcgctatatg attggagtca   4500

cctacggggg tgacgacatc ccactttctc cttatcgcat ccgagccaca cagacgggtg   4560

atgccagcaa gtgcctggcc acgggtcctg gaatcgcctc cactgtgaaa actggcgaag   4620

aagtaggctt tgtggttgat gccaagactg ccgggaaggg taaagtgacc tgcacggttc   4680

tgaccccaga tggcactgag gccgaggccg atgtcattga gaatgaagat ggaacctatg   4740

acatcttcta cacagctgcc aagccgggca catatgtgat ctatgtgcgc ttcggtggtg   4800

ttgatattcc taacagcccc ttcactgtca tggccacaga tggggaagtc acagccgtgg   4860

aggaggcacc ggtgaccgaa gaggcctatg tcccagtgag tgacatgaac ggcctgggat   4920

ttaagccttt tgacctggtc attccgtttg ctgtcaggaa aggagaaatc actggagagg   4980

tccacatgcc ttctgggaag acagccacac ctgagattgt ggacaacaag gacggcacgg   5040

tcactgttag atatgccccc actgaggtcg ggctccatga gatgcacatc aaatacatgg   5100

gcagccacat ccctgagagc ccactccagt tctacgtgaa ctaccccaac agtggaagtg   5160

tttctgcata cggtccaggc ctcgtgtatg gagtggccaa caaaactgcc accttcacca   5220

tcgtcacaga ggatgcagga gaaggtggtc tggacttggc tattgagggc ccctcaaaag   5280

cagaaatcag ctgcattgac aataaagatg ggacatgcac agtgacctac ctgccgactc   5340

tgccaggcga ctacagcatt ctggtcaagt acaatgacaa gcacatccct ggcagcccct   5400

tcacagccaa gatcacagat gacagcaggc ggtgctccca ggtgaagttg ggctcagccg   5460

ctgacttcct gctcgacatc agtgagactg acctcagcag cctgacggcc agcattaagg   5520

ccccatctgg ccgagacgag ccctgtctcc tgaagaggct gcccaacaac cacattggca   5580

tctccttcat cccccgggaa gtgggcgaac atctggtcag catcaagaaa aatggcaacc   5640

atgtggccaa cagccccgtg tctatcatgg tggtccagtc ggagattggt gacgcccgcc   5700

gagccaaagt ctatggccgc ggcctgtcag aaggccggac tttcgagatg tctgacttca   5760

tcgtggacac aagggatgca ggttatggtg gcatatcctt ggcggtggaa ggccccagca   5820

aagtggacat ccagacggag gacctggaag atggcacctg caaagtctcc tacttcccta   5880

ccgtgcctgg ggtttatatc gtctccacca aattcgctga cgagcacgtg cctgggagcc   5940

catttaccgt gaagatcagt ggggagggaa gagtcaaaga gagcatcacc cgcaccagtc   6000

gggccccgtc cgtggccact gtcgggagca tttgtgacct gaacctgaaa atcccagaaa   6060

tcaacagcag tgatatgtcg gcccacgtca ccagcccctc tggccgtgtg actgaggcag   6120

agattgtgcc catggggaag aactcacact gcgtccggtt tgtgccccag gagatgggcg   6180

tgcacacggt cagcgtcaag taccgtgggc agcacgtcac cggcagcccc ttccagttca   6240

ccgtggggcc acttggtgaa ggaggcgccc acaaggtgcg ggcaggaggc cctggcctgg   6300

agagaggaga agcgggagtc ccagctgagt tcagcatttg gacccgggaa gcaggcgctg   6360

gaggcctctc catcgctgtt gagggcccca gtaaggccga gattacattc gatgaccata   6420

aaaatgggtc gtgcggtgta tcttatattg cccaagagcc tggtaactac gaggtgtcca   6480

tcaagttcaa tgatgagcac atcccggaaa gcccctacct ggtgccggtc atcgcaccct   6540

ccgacgacgc ccgccgcctc actgttatga gccttcagga atcgggatta aaagttaacc   6600

agccagcatc ctttgctata aggttgaatg gcgcaaaagg caagattgat gcaaaggtgc   6660

acagcccctc tggagccgtg gaggagtgcc acgtgtctga gctggagcca gataagtatg   6720

ctgttcgctt catccctcat gagaatggtg tccacaccat cgatgtcaag ttcaatggga   6780

gccacgtggt tggaagcccc ttcaaagtgc gcgttgggga gcctggacaa gcggggaacc   6840

ctgccctggt gtccgcctat ggcacgggac tcgaaggggg caccacaggt atccagtcgg   6900

aattctttat taacaccacc cgagcaggtc cagggacatt atccgtcacc atcgaaggcc   6960

catccaaggt taaaatggat tgccaggaaa cacctgaagg gtacaaagtc atgtacaccc   7020

ccatggctcc tggtaactac ctgatcagcg tcaaatacgg tgggcccaac cacatcgtgg   7080

gcagtccctt caaggccaag gtgacaggcc agcgtctagt tagccctggc tcagccaacg   7140

agacctcatc catcctggtg gagtcagtga ccaggtcgtc tacagagacc tgctatagcg   7200

ccattcccaa ggcatcctcg gacgccagca aggtgacctc taagggggca gggctctcaa   7260

aggcctttgt gggccagaag agttccttcc tggtggactg cagcaaagct ggctccaaca   7320

tgctgctgat cggggtccat gggcccacca ccccctgcga ggaggtctcc atgaagcatg   7380

taggcaacca gcaatacaac gtcacatacg tcgtcaagga gaggggcgat tatgtgctgg   7440

ctgtgaagtg gggggaggaa cacatccctg gcagcccttt tcatgtcaca gtgccttaaa   7500

acagttttct caaatcctgg agagagttct tgtggttgct tttgttgctt gtttgtaatt   7560

cattttatac aaagccctcc agcctgtttg tggggctgaa accccatccc taaaatattg   7620

ctgttgtaaa atgccttcag aaataagtcc tagactggac tcttgaggga catattggag   7680

aatcttaaga aatgcaagct tgttcagggg gctgagaaga tcctgagtac actaggtgca   7740

aaccagaact cttggtggaa cagaccagcc actgcagcag acagaccagg aacacaatga   7800

gactgacatt tcaaaaaaac aaaactggct agcctgagct gctggttcac tcttcagcat   7860

ttatgaaaca aggctagggg aagatgggca gagaaaaagg ggacacctag tttggttgtc   7920

atttggcaaa ggagatgact taaaatccgc ttaatctctt ccagtgtccg tgttaatgta   7980

tttggctatt agatcactag cactgcttta ccgctcctca tcgccaacac ccccatgctc   8040

tgtggccttc ttacacttct cagagggcag agtggcagcc gggcacccta cagaaactca   8100

gagggcagag tggcagccag gcccacatgt ctctcaagta cctgtcccct cgctctggtg   8160

attatttctt gcagaatcac cacacgagac catcccggca gtcatggttt tgctttagtt   8220

ttccaagtcc gtttcagtcc cttccttggt ctgaagaaat tctgcagtgg cgagcagttt   8280

cccacttgcc aaagatccct tttaaccaac actagccctt gtttttaaca cacgctccag   8340

cccttcatca gcctgggcag tcttaccaaa atgtttaaag tgatctcaga ggggcccatg   8400

gattaacgcc ctcatcccaa ggtccgtccc atgacataac actccacacc cgccccagcc   8460

aacttcatgg gtcacttttt ctggaaaata atgatctgta cagacaggac agaatgaaac   8520

tcctgcgggt ctttggcctg aaagttggga atggttgggg gagagaaggg cagcagctta   8580

ttggtggtct tttcaccatt ggcagaaaca gtgagagctg tgtggtgcag aaatccagaa   8640

atgaggtgta gggaattttg cctgccttcc tgcagacctg agctggcttt ggaatgaggt   8700

taaagtgtca gggacgttgc ctgagcccaa atgtgtagtg tggtctgggc aggcagacct   8760

ttaggttttg ctgcttagtc ctgaggaagt ggccactctt gtggcaggtg tagtatctgg   8820

ggcgagtgtt gggggtaaaa gcccacccta cagaaagtgg aacagcccgg agcctgatgt   8880

gaaaggacca cgggtgttgt aagctgggac acggaagcca aactggaatc aaacgccgac   8940

tgtaaattgt atcttataac ttattaaata aaacatttgc tccgtaaagt tg           8992


<210>  1590
<211>  2422
<212>  PRT
<213>  Homo sapiens

<400>  1590


Met Gln Glu His Ser Thr Arg Arg Arg Ser Leu Ser Leu Cys Pro Asp 
1               5                   10                  15      


Trp Glu Ser Trp Asp Pro Gln Lys Pro Val Asp Asn Ala Arg Glu Ala 
            20                  25                  30          


Met Gln Gln Ala Asp Asp Trp Leu Gly Val Pro Gln Val Ile Thr Pro 
        35                  40                  45              


Glu Glu Ile Ile His Pro Asp Val Asp Glu His Ser Val Met Thr Tyr 
    50                  55                  60                  


Leu Ser Gln Phe Pro Lys Ala Lys Leu Lys Pro Gly Ala Pro Leu Lys 
65                  70                  75                  80  


Pro Lys Leu Asn Pro Lys Lys Ala Arg Ala Tyr Gly Arg Gly Ile Glu 
                85                  90                  95      


Pro Thr Gly Asn Met Val Lys Gln Pro Ala Lys Phe Thr Val Asp Thr 
            100                 105                 110         


Ile Ser Ala Gly Gln Gly Asp Val Met Val Phe Val Glu Asp Pro Glu 
        115                 120                 125             


Gly Asn Lys Glu Glu Ala Gln Val Thr Pro Asp Ser Asp Lys Asn Lys 
    130                 135                 140                 


Thr Tyr Ser Val Glu Tyr Leu Pro Lys Val Thr Gly Leu His Lys Val 
145                 150                 155                 160 


Thr Val Leu Phe Ala Gly Gln His Ile Ser Lys Ser Pro Phe Glu Val 
                165                 170                 175     


Ser Val Asp Lys Ala Gln Gly Asp Ala Ser Lys Val Thr Ala Lys Gly 
            180                 185                 190         


Pro Gly Leu Glu Ala Val Gly Asn Ile Ala Asn Lys Pro Thr Tyr Phe 
        195                 200                 205             


Asp Ile Tyr Thr Ala Gly Ala Gly Val Gly Asp Ile Gly Val Glu Val 
    210                 215                 220                 


Glu Asp Pro Gln Gly Lys Asn Thr Val Glu Leu Leu Val Glu Asp Lys 
225                 230                 235                 240 


Gly Asn Gln Val Tyr Arg Cys Val Tyr Lys Pro Met Gln Pro Gly Pro 
                245                 250                 255     


His Val Val Lys Ile Phe Phe Ala Gly Asp Thr Ile Pro Lys Ser Pro 
            260                 265                 270         


Phe Val Val Gln Val Gly Glu Ala Cys Asn Pro Asn Ala Cys Arg Ala 
        275                 280                 285             


Ser Gly Arg Gly Leu Gln Pro Lys Gly Val Arg Ile Arg Glu Thr Thr 
    290                 295                 300                 


Asp Phe Lys Val Asp Thr Lys Ala Ala Gly Ser Gly Glu Leu Gly Val 
305                 310                 315                 320 


Thr Met Lys Gly Pro Lys Gly Leu Glu Glu Leu Val Lys Gln Lys Asp 
                325                 330                 335     


Phe Leu Asp Gly Val Tyr Ala Phe Glu Tyr Tyr Pro Ser Thr Pro Gly 
            340                 345                 350         


Arg Tyr Ser Ile Ala Ile Thr Trp Gly Gly His His Ile Pro Lys Ser 
        355                 360                 365             


Pro Phe Glu Val Gln Val Gly Pro Glu Ala Gly Met Gln Lys Val Arg 
    370                 375                 380                 


Ala Trp Gly Pro Gly Leu His Gly Gly Ile Val Gly Arg Ser Ala Asp 
385                 390                 395                 400 


Phe Val Val Glu Ser Ile Gly Ser Glu Val Gly Ser Leu Gly Phe Ala 
                405                 410                 415     


Ile Glu Gly Pro Ser Gln Ala Lys Ile Glu Tyr Asn Asp Gln Asn Asp 
            420                 425                 430         


Gly Ser Cys Asp Val Lys Tyr Trp Pro Lys Glu Pro Gly Glu Tyr Ala 
        435                 440                 445             


Val His Ile Met Cys Asp Asp Glu Asp Ile Lys Asp Ser Pro Tyr Met 
    450                 455                 460                 


Ala Phe Ile His Pro Ala Thr Gly Gly Tyr Asn Pro Asp Leu Val Arg 
465                 470                 475                 480 


Ala Tyr Gly Pro Gly Leu Glu Lys Ser Gly Cys Ile Val Asn Asn Leu 
                485                 490                 495     


Ala Glu Phe Thr Val Asp Pro Lys Asp Ala Gly Lys Ala Pro Leu Lys 
            500                 505                 510         


Ile Phe Ala Gln Asp Gly Glu Gly Gln Arg Ile Asp Ile Gln Met Lys 
        515                 520                 525             


Asn Arg Met Asp Gly Thr Tyr Ala Cys Ser Tyr Thr Pro Val Lys Ala 
    530                 535                 540                 


Ile Lys His Thr Ile Ala Val Val Trp Gly Gly Val Asn Ile Pro His 
545                 550                 555                 560 


Ser Pro Tyr Arg Val Asn Ile Gly Gln Gly Ser His Pro Gln Lys Val 
                565                 570                 575     


Lys Val Phe Gly Pro Gly Val Glu Arg Ser Gly Leu Lys Ala Asn Glu 
            580                 585                 590         


Pro Thr His Phe Thr Val Asp Cys Thr Glu Ala Gly Glu Gly Asp Val 
        595                 600                 605             


Ser Val Gly Ile Lys Cys Asp Ala Arg Val Leu Ser Glu Asp Glu Glu 
    610                 615                 620                 


Asp Val Asp Phe Asp Ile Ile His Asn Ala Asn Asp Thr Phe Thr Val 
625                 630                 635                 640 


Lys Tyr Val Pro Pro Ala Ala Gly Arg Tyr Thr Ile Lys Val Leu Phe 
                645                 650                 655     


Ala Ser Gln Glu Ile Pro Ala Ser Pro Phe Arg Val Lys Val Asp Pro 
            660                 665                 670         


Ser His Asp Ala Ser Lys Val Lys Ala Glu Gly Pro Gly Leu Ser Lys 
        675                 680                 685             


Ala Gly Val Glu Asn Gly Lys Pro Thr His Phe Thr Val Tyr Thr Lys 
    690                 695                 700                 


Gly Ala Gly Lys Ala Pro Leu Asn Val Gln Phe Asn Ser Pro Leu Pro 
705                 710                 715                 720 


Gly Asp Ala Val Lys Asp Leu Asp Ile Ile Asp Asn Tyr Asp Tyr Ser 
                725                 730                 735     


His Thr Val Lys Tyr Thr Pro Thr Gln Gln Gly Asn Met Gln Val Leu 
            740                 745                 750         


Val Thr Tyr Gly Gly Asp Pro Ile Pro Lys Ser Pro Phe Thr Val Gly 
        755                 760                 765             


Val Ala Ala Pro Leu Asp Leu Ser Lys Ile Lys Leu Asn Gly Leu Glu 
    770                 775                 780                 


Asn Arg Val Glu Val Gly Lys Asp Gln Glu Phe Thr Val Asp Thr Arg 
785                 790                 795                 800 


Gly Ala Gly Gly Gln Gly Lys Leu Asp Val Thr Ile Leu Ser Pro Ser 
                805                 810                 815     


Arg Lys Val Val Pro Cys Leu Val Thr Pro Val Thr Gly Arg Glu Asn 
            820                 825                 830         


Ser Thr Ala Lys Phe Ile Pro Arg Glu Glu Gly Leu Tyr Ala Val Asp 
        835                 840                 845             


Val Thr Tyr Asp Gly His Pro Val Pro Gly Ser Pro Tyr Thr Val Glu 
    850                 855                 860                 


Ala Ser Leu Pro Pro Asp Pro Ser Lys Val Lys Ala His Gly Pro Gly 
865                 870                 875                 880 


Leu Glu Gly Gly Leu Val Gly Lys Pro Ala Glu Phe Thr Ile Asp Thr 
                885                 890                 895     


Lys Gly Ala Gly Thr Gly Gly Leu Gly Leu Thr Val Glu Gly Pro Cys 
            900                 905                 910         


Glu Ala Lys Ile Glu Cys Ser Asp Asn Gly Asp Gly Thr Cys Ser Val 
        915                 920                 925             


Ser Tyr Leu Pro Thr Lys Pro Gly Glu Tyr Phe Val Asn Ile Leu Phe 
    930                 935                 940                 


Glu Glu Val His Ile Pro Gly Ser Pro Phe Lys Ala Asp Ile Glu Met 
945                 950                 955                 960 


Pro Phe Asp Pro Ser Lys Val Val Ala Ser Gly Pro Gly Leu Glu His 
                965                 970                 975     


Gly Lys Val Gly Glu Ala Gly Leu Leu Ser Val Asp Cys Ser Glu Ala 
            980                 985                 990         


Gly Pro Gly Ala Leu Gly Leu Glu  Ala Val Ser Asp Ser  Gly Thr Lys 
        995                 1000                 1005             


Ala Glu  Val Ser Ile Gln Asn  Asn Lys Asp Gly Thr  Tyr Ala Val 
    1010                 1015                 1020             


Thr Tyr  Val Pro Leu Thr Ala  Gly Met Tyr Thr Leu  Thr Met Lys 
    1025                 1030                 1035             


Tyr Gly  Gly Glu Leu Val Pro  His Phe Pro Ala Arg  Val Lys Val 
    1040                 1045                 1050             


Glu Pro  Ala Val Asp Thr Ser  Arg Ile Lys Val Phe  Gly Pro Gly 
    1055                 1060                 1065             


Ile Glu  Gly Lys Asp Val Phe  Arg Glu Ala Thr Thr  Asp Phe Thr 
    1070                 1075                 1080             


Val Asp  Ser Arg Pro Leu Thr  Gln Val Gly Gly Asp  His Ile Lys 
    1085                 1090                 1095             


Ala His  Ile Ala Asn Pro Ser  Gly Ala Ser Thr Glu  Cys Phe Val 
    1100                 1105                 1110             


Thr Asp  Asn Ala Asp Gly Thr  Tyr Gln Val Glu Tyr  Thr Pro Phe 
    1115                 1120                 1125             


Glu Lys  Gly Leu His Val Val  Glu Val Thr Tyr Asp  Asp Val Pro 
    1130                 1135                 1140             


Ile Pro  Asn Ser Pro Phe Lys  Val Ala Val Thr Glu  Gly Cys Gln 
    1145                 1150                 1155             


Pro Ser  Arg Val Gln Ala Gln  Gly Pro Gly Leu Lys  Glu Ala Phe 
    1160                 1165                 1170             


Thr Asn  Lys Pro Asn Val Phe  Thr Val Val Thr Arg  Gly Ala Gly 
    1175                 1180                 1185             


Ile Gly  Gly Leu Gly Ile Thr  Val Glu Gly Pro Ser  Glu Ser Lys 
    1190                 1195                 1200             


Ile Asn  Cys Arg Asp Asn Lys  Asp Gly Ser Cys Ser  Ala Glu Tyr 
    1205                 1210                 1215             


Ile Pro  Phe Ala Pro Gly Asp  Tyr Asp Val Asn Ile  Thr Tyr Gly 
    1220                 1225                 1230             


Gly Ala  His Ile Pro Gly Ser  Pro Phe Arg Val Pro  Val Lys Asp 
    1235                 1240                 1245             


Val Val  Asp Pro Ser Lys Val  Lys Ile Ala Gly Pro  Gly Leu Gly 
    1250                 1255                 1260             


Ser Gly  Val Arg Ala Arg Val  Leu Gln Ser Phe Thr  Val Asp Ser 
    1265                 1270                 1275             


Ser Lys  Ala Gly Leu Ala Pro  Leu Glu Val Arg Val  Leu Gly Pro 
    1280                 1285                 1290             


Arg Gly  Leu Val Glu Pro Val  Asn Val Val Asp Asn  Gly Asp Gly 
    1295                 1300                 1305             


Thr His  Thr Val Thr Tyr Thr  Pro Ser Gln Glu Gly  Pro Tyr Met 
    1310                 1315                 1320             


Val Ser  Val Lys Tyr Ala Asp  Glu Glu Ile Pro Arg  Ser Pro Phe 
    1325                 1330                 1335             


Lys Val  Lys Val Leu Pro Thr  Tyr Asp Ala Ser Lys  Val Thr Ala 
    1340                 1345                 1350             


Ser Gly  Pro Gly Leu Ser Ser  Tyr Gly Val Pro Ala  Ser Leu Pro 
    1355                 1360                 1365             


Val Asp  Phe Ala Ile Asp Ala  Arg Asp Ala Gly Glu  Gly Leu Leu 
    1370                 1375                 1380             


Ala Val  Gln Ile Thr Asp Gln  Glu Gly Lys Pro Lys  Arg Ala Ile 
    1385                 1390                 1395             


Val His  Asp Asn Lys Asp Gly  Thr Tyr Ala Val Thr  Tyr Ile Pro 
    1400                 1405                 1410             


Asp Lys  Thr Gly Arg Tyr Met  Ile Gly Val Thr Tyr  Gly Gly Asp 
    1415                 1420                 1425             


Asp Ile  Pro Leu Ser Pro Tyr  Arg Ile Arg Ala Thr  Gln Thr Gly 
    1430                 1435                 1440             


Asp Ala  Ser Lys Cys Leu Ala  Thr Gly Pro Gly Ile  Ala Ser Thr 
    1445                 1450                 1455             


Val Lys  Thr Gly Glu Glu Val  Gly Phe Val Val Asp  Ala Lys Thr 
    1460                 1465                 1470             


Ala Gly  Lys Gly Lys Val Thr  Cys Thr Val Leu Thr  Pro Asp Gly 
    1475                 1480                 1485             


Thr Glu  Ala Glu Ala Asp Val  Ile Glu Asn Glu Asp  Gly Thr Tyr 
    1490                 1495                 1500             


Asp Ile  Phe Tyr Thr Ala Ala  Lys Pro Gly Thr Tyr  Val Ile Tyr 
    1505                 1510                 1515             


Val Arg  Phe Gly Gly Val Asp  Ile Pro Asn Ser Pro  Phe Thr Val 
    1520                 1525                 1530             


Met Ala  Thr Asp Gly Glu Val  Thr Ala Val Glu Glu  Ala Pro Val 
    1535                 1540                 1545             


Thr Glu  Glu Ala Tyr Val Pro  Val Ser Asp Met Asn  Gly Leu Gly 
    1550                 1555                 1560             


Phe Lys  Pro Phe Asp Leu Val  Ile Pro Phe Ala Val  Arg Lys Gly 
    1565                 1570                 1575             


Glu Ile  Thr Gly Glu Val His  Met Pro Ser Gly Lys  Thr Ala Thr 
    1580                 1585                 1590             


Pro Glu  Ile Val Asp Asn Lys  Asp Gly Thr Val Thr  Val Arg Tyr 
    1595                 1600                 1605             


Ala Pro  Thr Glu Val Gly Leu  His Glu Met His Ile  Lys Tyr Met 
    1610                 1615                 1620             


Gly Ser  His Ile Pro Glu Ser  Pro Leu Gln Phe Tyr  Val Asn Tyr 
    1625                 1630                 1635             


Pro Asn  Ser Gly Ser Val Ser  Ala Tyr Gly Pro Gly  Leu Val Tyr 
    1640                 1645                 1650             


Gly Val  Ala Asn Lys Thr Ala  Thr Phe Thr Ile Val  Thr Glu Asp 
    1655                 1660                 1665             


Ala Gly  Glu Gly Gly Leu Asp  Leu Ala Ile Glu Gly  Pro Ser Lys 
    1670                 1675                 1680             


Ala Glu  Ile Ser Cys Ile Asp  Asn Lys Asp Gly Thr  Cys Thr Val 
    1685                 1690                 1695             


Thr Tyr  Leu Pro Thr Leu Pro  Gly Asp Tyr Ser Ile  Leu Val Lys 
    1700                 1705                 1710             


Tyr Asn  Asp Lys His Ile Pro  Gly Ser Pro Phe Thr  Ala Lys Ile 
    1715                 1720                 1725             


Thr Asp  Asp Ser Arg Arg Cys  Ser Gln Val Lys Leu  Gly Ser Ala 
    1730                 1735                 1740             


Ala Asp  Phe Leu Leu Asp Ile  Ser Glu Thr Asp Leu  Ser Ser Leu 
    1745                 1750                 1755             


Thr Ala  Ser Ile Lys Ala Pro  Ser Gly Arg Asp Glu  Pro Cys Leu 
    1760                 1765                 1770             


Leu Lys  Arg Leu Pro Asn Asn  His Ile Gly Ile Ser  Phe Ile Pro 
    1775                 1780                 1785             


Arg Glu  Val Gly Glu His Leu  Val Ser Ile Lys Lys  Asn Gly Asn 
    1790                 1795                 1800             


His Val  Ala Asn Ser Pro Val  Ser Ile Met Val Val  Gln Ser Glu 
    1805                 1810                 1815             


Ile Gly  Asp Ala Arg Arg Ala  Lys Val Tyr Gly Arg  Gly Leu Ser 
    1820                 1825                 1830             


Glu Gly  Arg Thr Phe Glu Met  Ser Asp Phe Ile Val  Asp Thr Arg 
    1835                 1840                 1845             


Asp Ala  Gly Tyr Gly Gly Ile  Ser Leu Ala Val Glu  Gly Pro Ser 
    1850                 1855                 1860             


Lys Val  Asp Ile Gln Thr Glu  Asp Leu Glu Asp Gly  Thr Cys Lys 
    1865                 1870                 1875             


Val Ser  Tyr Phe Pro Thr Val  Pro Gly Val Tyr Ile  Val Ser Thr 
    1880                 1885                 1890             


Lys Phe  Ala Asp Glu His Val  Pro Gly Ser Pro Phe  Thr Val Lys 
    1895                 1900                 1905             


Ile Ser  Gly Glu Gly Arg Val  Lys Glu Ser Ile Thr  Arg Thr Ser 
    1910                 1915                 1920             


Arg Ala  Pro Ser Val Ala Thr  Val Gly Ser Ile Cys  Asp Leu Asn 
    1925                 1930                 1935             


Leu Lys  Ile Pro Glu Ile Asn  Ser Ser Asp Met Ser  Ala His Val 
    1940                 1945                 1950             


Thr Ser  Pro Ser Gly Arg Val  Thr Glu Ala Glu Ile  Val Pro Met 
    1955                 1960                 1965             


Gly Lys  Asn Ser His Cys Val  Arg Phe Val Pro Gln  Glu Met Gly 
    1970                 1975                 1980             


Val His  Thr Val Ser Val Lys  Tyr Arg Gly Gln His  Val Thr Gly 
    1985                 1990                 1995             


Ser Pro  Phe Gln Phe Thr Val  Gly Pro Leu Gly Glu  Gly Gly Ala 
    2000                 2005                 2010             


His Lys  Val Arg Ala Gly Gly  Pro Gly Leu Glu Arg  Gly Glu Ala 
    2015                 2020                 2025             


Gly Val  Pro Ala Glu Phe Ser  Ile Trp Thr Arg Glu  Ala Gly Ala 
    2030                 2035                 2040             


Gly Gly  Leu Ser Ile Ala Val  Glu Gly Pro Ser Lys  Ala Glu Ile 
    2045                 2050                 2055             


Thr Phe  Asp Asp His Lys Asn  Gly Ser Cys Gly Val  Ser Tyr Ile 
    2060                 2065                 2070             


Ala Gln  Glu Pro Gly Asn Tyr  Glu Val Ser Ile Lys  Phe Asn Asp 
    2075                 2080                 2085             


Glu His  Ile Pro Glu Ser Pro  Tyr Leu Val Pro Val  Ile Ala Pro 
    2090                 2095                 2100             


Ser Asp  Asp Ala Arg Arg Leu  Thr Val Met Ser Leu  Gln Glu Ser 
    2105                 2110                 2115             


Gly Leu  Lys Val Asn Gln Pro  Ala Ser Phe Ala Ile  Arg Leu Asn 
    2120                 2125                 2130             


Gly Ala  Lys Gly Lys Ile Asp  Ala Lys Val His Ser  Pro Ser Gly 
    2135                 2140                 2145             


Ala Val  Glu Glu Cys His Val  Ser Glu Leu Glu Pro  Asp Lys Tyr 
    2150                 2155                 2160             


Ala Val  Arg Phe Ile Pro His  Glu Asn Gly Val His  Thr Ile Asp 
    2165                 2170                 2175             


Val Lys  Phe Asn Gly Ser His  Val Val Gly Ser Pro  Phe Lys Val 
    2180                 2185                 2190             


Arg Val  Gly Glu Pro Gly Gln  Ala Gly Asn Pro Ala  Leu Val Ser 
    2195                 2200                 2205             


Ala Tyr  Gly Thr Gly Leu Glu  Gly Gly Thr Thr Gly  Ile Gln Ser 
    2210                 2215                 2220             


Glu Phe  Phe Ile Asn Thr Thr  Arg Ala Gly Pro Gly  Thr Leu Ser 
    2225                 2230                 2235             


Val Thr  Ile Glu Gly Pro Ser  Lys Val Lys Met Asp  Cys Gln Glu 
    2240                 2245                 2250             


Thr Pro  Glu Gly Tyr Lys Val  Met Tyr Thr Pro Met  Ala Pro Gly 
    2255                 2260                 2265             


Asn Tyr  Leu Ile Ser Val Lys  Tyr Gly Gly Pro Asn  His Ile Val 
    2270                 2275                 2280             


Gly Ser  Pro Phe Lys Ala Lys  Val Thr Gly Gln Arg  Leu Val Ser 
    2285                 2290                 2295             


Pro Gly  Ser Ala Asn Glu Thr  Ser Ser Ile Leu Val  Glu Ser Val 
    2300                 2305                 2310             


Thr Arg  Ser Ser Thr Glu Thr  Cys Tyr Ser Ala Ile  Pro Lys Ala 
    2315                 2320                 2325             


Ser Ser  Asp Ala Ser Lys Val  Thr Ser Lys Gly Ala  Gly Leu Ser 
    2330                 2335                 2340             


Lys Ala  Phe Val Gly Gln Lys  Ser Ser Phe Leu Val  Asp Cys Ser 
    2345                 2350                 2355             


Lys Ala  Gly Ser Asn Met Leu  Leu Ile Gly Val His  Gly Pro Thr 
    2360                 2365                 2370             


Thr Pro  Cys Glu Glu Val Ser  Met Lys His Val Gly  Asn Gln Gln 
    2375                 2380                 2385             


Tyr Asn  Val Thr Tyr Val Val  Lys Glu Arg Gly Asp  Tyr Val Leu 
    2390                 2395                 2400             


Ala Val  Lys Trp Gly Glu Glu  His Ile Pro Gly Ser  Pro Phe His 
    2405                 2410                 2415             


Val Thr  Val Pro 
    2420         

<210>  1591
<211>  7408
<212>  DNA
<213>  Homo sapiens

<400>  1591
atttttgaat cacacaggat gctattctag actttttaga tatatccagg aatagagtaa     60

aaaataaaat ccctcctgca taaaggcacc aggctttttc caagctttgt ttatttttta    120

acaccacttc ttcaaggaat ggataatccc catcttcatg caagaacata gcacccggag    180

gagaagtctc agtctgtgcc cagactggga atcctgggac ccgcagaagc ctgtggataa    240

tgcacgagaa gccatgcagc aggcagatga ctggctgggt gtcccacagg tcatcactcc    300

tgaagaaatc attcacccgg atgtggacga gcactcagtt atgacttacc tgtcccagtt    360

ccccaaagcc aagctcaagc cgggggctcc tctcaaaccc aaactcaacc cgaagaaagc    420

cagggcctat ggcagaggaa tcgagcccac tggaaacatg gtgaagcagc cagccaagtt    480

cactgtggac accatcagcg ccgggcaagg agacgtgatg gtgtttgttg aggacccaga    540

agggaacaaa gaggaggcac aagtgacccc tgacagtgac aagaacaaga catactctgt    600

ggagtatctg cccaaggtca ccgggctaca caaagtcaca gtcctctttg caggacagca    660

catctccaag agcccatttg aagtgagtgt tgacaaggcc cagggagatg ccagtaaagt    720

cactgcaaaa ggtccagggt tggaagctgt agggaacatc gccaataagc ccacctactt    780

tgacatctat acggcaggag ctggtgtggg tgacattggt gtggaggtgg aagatcccca    840

ggggaagaac accgtggagt tgctcgtgga agacaaagga aaccaggtgt atcgatgtgt    900

gtacaaaccc atgcagcctg gccctcacgt ggtcaagatc ttctttgctg gggacactat    960

tcctaagagt cccttcgttg tgcaggttgg ggaagcctgc aatccaaatg cctgccgggc   1020

cagtggccga ggcctacaac ccaaaggcgt ccgtatccgg gagaccacag atttcaaggt   1080

tgacaccaaa gctgcaggaa gtggggagct cggtgtaacc atgaagggtc ctaagggtct   1140

ggaggagctg gtgaagcaga aagactttct ggatggggtc tacgcattcg agtattaccc   1200

cagcaccccg gggagataca gcattgccat cacatggggg ggacaccaca ttccaaagag   1260

cccctttgaa gttcaagttg gccctgaagc gggtatgcag aaagtccgtg cttggggccc   1320

tgggctccat ggtgggattg tcgggcggtc agcggacttc gtggtagaat ccattggctc   1380

tgaagtgggg tctctggggt ttgccattga aggcccctct caggcaaaga ttgagtacaa   1440

cgaccagaat gatggatcgt gtgatgtcaa atactggccc aaggagcctg gcgaatatgc   1500

tgttcacatc atgtgtgacg acgaagacat caaggacagc ccgtacatgg ccttcatcca   1560

cccagccacg ggaggctaca accctgatct ggttcgagca tacgggccag gtttggagaa   1620

atctggatgc attgtcaaca acctggccga gttcactgtg gatcctaagg atgctggaaa   1680

agctccctta aagatatttg ctcaggatgg ggaaggccaa cgcattgaca tccagatgaa   1740

gaaccggatg gacggcacat atgcatgctc atacaccccg gtgaaggcca tcaagcacac   1800

cattgctgtg gtctggggag gcgtgaacat cccgcacagc ccctacaggg tcaacatcgg   1860

gcaaggtagc catcctcaga aggtcaaagt gtttgggcca ggtgtggaga gaagtggtct   1920

gaaggcaaat gaacctacac acttcacggt ggactgtact gaggctgggg aaggtgatgt   1980

cagtgttggc attaagtgtg atgcccgggt gttaagtgaa gatgaggaag acgtggattt   2040

tgacattatt cacaatgcca atgatacgtt cacagtcaaa tatgtgcctc ctgctgctgg   2100

gcgatacact atcaaagttc tctttgcatc tcaggaaatc cccgccagcc ctttcagagt   2160

caaagttgac ccttcccacg atgccagcaa agtgaaggca gaaggcccag ggctcagcaa   2220

agcaggtgtg gaaaatggga aaccgaccca cttcactgtc tacaccaagg gggctgggaa   2280

agccccgctc aacgtgcagt tcaacagccc tcttcctggc gatgcagtga aggatttgga   2340

tatcatcgat aattatgact actctcacac ggttaaatat acacccaccc aacagggcaa   2400

catgcaggtt ctggtgactt acggtggcga tcccatccct aaaagccctt tcactgtggg   2460

tgttgctgca ccgctggatc tgagcaagat aaaactcaat gggctggaaa acagggtgga   2520

agttgggaag gatcaggagt tcaccgttga taccaggggg gcaggaggcc aggggaagct   2580

ggacgtgaca atcctcagcc cctctcggaa ggtcgtgcca tgcctagtga cacctgtgac   2640

aggccgggag aacagcacgg ccaagttcat ccctcgggag gaggggctgt atgctgtaga   2700

cgtgacctac gatggacacc ctgtgcccgg gagcccctac acagtggagg cctcgctgcc   2760

accagatccc agcaaggtga aggcccacgg tcccggcctc gaaggtggtc tcgtgggcaa   2820

gcctgccgag ttcaccatcg ataccaaagg agctggtact ggaggtctgg gcttaacggt   2880

ggaaggtccg tgcgaggcca aaatcgagtg ctccgacaat ggtgatggga cctgctccgt   2940

ctcttacctt cccacaaaac ccggggagta cttcgtcaac atcctctttg aagaagtcca   3000

catacctggg tctcccttca aagctgacat tgaaatgccc tttgacccct ctaaagtcgt   3060

ggcatcgggg ccaggtctcg agcacgggaa ggtgggtgaa gctggcctcc ttagcgtcga   3120

ctgctcggaa gcgggaccgg gggccctggg cctggaagct gtctcggact cgggaacaaa   3180

agccgaagtc agtattcaga acaacaaaga tggcacctac gcggtgacct acgtgcccct   3240

gacggccggc atgtacacgt tgaccatgaa gtatggtggc gaactcgtgc cacacttccc   3300

cgcccgggtc aaggtggagc ccgccgtgga caccagcagg atcaaagtct ttggaccagg   3360

aatagaaggg aaagatgtgt tccgggaagc taccaccgac tttacagttg actctcggcc   3420

gctgacccag gttgggggtg accacatcaa ggcccacatt gccaacccct caggggcctc   3480

caccgagtgc tttgtcacag acaatgcgga tgggacctac caggtggaat acacaccctt   3540

tgagaaaggt ctccatgtag tggaggtgac atatgatgac gtgcctatcc caaacagtcc   3600

cttcaaggtg gctgtcactg aaggctgcca gccatctagg gtgcaagccc aaggacctgg   3660

attgaaagag gcctttacca acaagcccaa tgtcttcacc gtggttacca gaggcgcagg   3720

aattggtggg cttggcataa ctgttgaggg accatcagag tcgaagataa attgcagaga   3780

caacaaggat ggcagctgca gtgctgagta cattcctttc gcaccggggg attacgatgt   3840

taatatcaca tatggaggag cccacatccc cggcagcccc ttcagggttc ctgtgaagga   3900

tgttgtggac cccagcaagg tcaagattgc cggccccggg ctgggctcag gcgtccgagc   3960

ccgtgtcctg cagtccttca cggtggacag cagcaaggct ggcctggctc cgctggaagt   4020

gagggttctg ggcccacgag gcttggtgga gccagtgaac gtggtggaca atggagatgg   4080

cacacacaca gtaacctaca ccccatctca ggagggacct tacatggtct cagttaaata   4140

tgctgatgaa gagattcctc gcagtccctt caaggtcaag gtccttccca catatgatgc   4200

cagcaaagtg actgccagtg gccccggcct tagttcctat ggtgtgcctg ccagtctacc   4260

tgtggacttt gcaattgatg cccgagatgc cggggaaggc ctgcttgctg ttcaaataac   4320

ggaccaagaa ggaaaaccca aaagagccat tgtccatgac aataaagatg gcacgtatgc   4380

tgtcacctac atccccgaca agactgggcg ctatatgatt ggagtcacct acgggggtga   4440

cgacatccca ctttctcctt atcgcatccg agccacacag acgggtgatg ccagcaagtg   4500

cctggccacg ggtcctggaa tcgcctccac tgtgaaaact ggcgaagaag taggctttgt   4560

ggttgatgcc aagactgccg ggaagggtaa agtgacctgc acggttctga ccccagatgg   4620

cactgaggcc gaggccgatg tcattgagaa tgaagatgga acctatgaca tcttctacac   4680

agctgccaag ccgggcacat atgtgatcta tgtgcgcttc ggtggtgttg atattcctaa   4740

cagccccttc actgtcatgg tgaccgaaga ggcctatgtc ccagtgagtg acatgaacgg   4800

cctgggattt aagccttttg acctggtcat tccgtttgct gtcaggaaag gagaaatcac   4860

tggagaggtc cacatgcctt ctgggaagac agccacacct gagattgtgg acaacaagga   4920

cggcacggtc actgttagat atgcccccac tgaggtcggg ctccatgaga tgcacatcaa   4980

atacatgggc agccacatcc ctgagagccc actccagttc tacgtgaact accccaacag   5040

tggaagtgtt tctgcatacg gtccaggcct cgtgtatgga gtggccaaca aaactgccac   5100

cttcaccatc gtcacagagg atgcaggaga aggtggtctg gacttggcta ttgagggccc   5160

ctcaaaagca gaaatcagct gcattgacaa taaagatggg acatgcacag tgacctacct   5220

gccgactctg ccaggcgact acagcattct ggtcaagtac aatgacaagc acatccctgg   5280

cagccccttc acagccaaga tcacagatga cagcaggcgg tgctcccagg tgaagttggg   5340

ctcagccgct gacttcctgc tcgacatcag tgagactgac ctcagcagcc tgacggccag   5400

cattaaggcc ccatctggcc gagacgagcc ctgtctcctg aagaggctgc ccaacaacca   5460

cattggcatc tccttcatcc cccgggaagt gggcgaacat ctggtcagca tcaagaaaaa   5520

tggcaaccat gtggccaaca gccccgtgtc tatcatggtg gtccagtcgg agattggtga   5580

cgcccgccga gccaaagtct atggccgcgg cctgtcagaa ggccggactt tcgagatgtc   5640

tgacttcatc gtggacacaa gggatgcagg ttatggtggc atatccttgg cggtggaagg   5700

ccccagcaaa gtggacatcc agacggagga cctggaagat ggcacctgca aagtctccta   5760

cttccctacc gtgcctgggg tttatatcgt ctccaccaaa ttcgctgacg agcacgtgcc   5820

tgggagccca tttaccgtga agatcagtgg ggagggaaga gtcaaagaga gcatcacccg   5880

caccagtcgg gccccgtccg tggccactgt cgggagcatt tgtgacctga acctgaaaat   5940

cccagaaatc aacagcagtg atatgtcggc ccacgtcacc agcccctctg gccgtgtgac   6000

tgaggcagag attgtgccca tggggaagaa ctcacactgc gtccggtttg tgccccagga   6060

gatgggcgtg cacacggtca gcgtcaagta ccgtgggcag cacgtcaccg gcagcccctt   6120

ccagttcacc gtggggccac ttggtgaagg aggcgcccac aaggtgcggg caggaggccc   6180

tggcctggag agaggagaag cgggagtccc agctgagttc agcatttgga cccgggaagc   6240

aggcgctgga ggcctctcca tcgctgttga gggccccagt aaggccgaga ttacattcga   6300

tgaccataaa aatgggtcgt gcggtgtatc ttatattgcc caagagcctg gtaactacga   6360

ggtgtccatc aagttcaatg atgagcacat cccggaaagc ccctacctgg tgccggtcat   6420

cgcaccctcc gacgacgccc gccgcctcac tgttatgagc cttcaggaat cgggattaaa   6480

agttaaccag ccagcatcct ttgctataag gttgaatggc gcaaaaggca agattgatgc   6540

aaaggtgcac agcccctctg gagccgtgga ggagtgccac gtgtctgagc tggagccaga   6600

taagtatgct gttcgcttca tccctcatga gaatggtgtc cacaccatcg atgtcaagtt   6660

caatgggagc cacgtggttg gaagcccctt caaagtgcgc gttggggagc ctggacaagc   6720

ggggaaccct gccctggtgt ccgcctatgg cacgggactc gaagggggca ccacaggtat   6780

ccagtcggaa ttctttatta acaccacccg agcaggtcca gggacattat ccgtcaccat   6840

cgaaggccca tccaaggtta aaatggattg ccaggaaaca cctgaagggt acaaagtcat   6900

gtacaccccc atggctcctg gtaactacct gatcagcgtc aaatacggtg ggcccaacca   6960

catcgtgggc agtcccttca aggccaaggt gacaggccag cgtctagtta gccctggctc   7020

agccaacgag acctcatcca tcctggtgga gtcagtgacc aggtcgtcta cagagacctg   7080

ctatagcgcc attcccaagg catcctcgga cgccagcaag gtgacctcta agggggcagg   7140

gctctcaaag gcctttgtgg gccagaagag ttccttcctg gtggactgca gcaaagctgg   7200

ctccaacatg ctgctgatcg gggtccatgg gcccaccacc ccctgcgagg aggtctccat   7260

gaagcatgta ggcaaccagc aatacaacgt cacatacgtc gtcaaggaga ggggcgatta   7320

tgtgctggct gtgaagtggg gggaggaaca catccctggc agcccttttc atgtcacagt   7380

gccttaaaac agttttctca aatcctgg                                      7408


<210>  1592
<211>  2409
<212>  PRT
<213>  Homo sapiens

<400>  1592


Met Gln Glu His Ser Thr Arg Arg Arg Ser Leu Ser Leu Cys Pro Asp 
1               5                   10                  15      


Trp Glu Ser Trp Asp Pro Gln Lys Pro Val Asp Asn Ala Arg Glu Ala 
            20                  25                  30          


Met Gln Gln Ala Asp Asp Trp Leu Gly Val Pro Gln Val Ile Thr Pro 
        35                  40                  45              


Glu Glu Ile Ile His Pro Asp Val Asp Glu His Ser Val Met Thr Tyr 
    50                  55                  60                  


Leu Ser Gln Phe Pro Lys Ala Lys Leu Lys Pro Gly Ala Pro Leu Lys 
65                  70                  75                  80  


Pro Lys Leu Asn Pro Lys Lys Ala Arg Ala Tyr Gly Arg Gly Ile Glu 
                85                  90                  95      


Pro Thr Gly Asn Met Val Lys Gln Pro Ala Lys Phe Thr Val Asp Thr 
            100                 105                 110         


Ile Ser Ala Gly Gln Gly Asp Val Met Val Phe Val Glu Asp Pro Glu 
        115                 120                 125             


Gly Asn Lys Glu Glu Ala Gln Val Thr Pro Asp Ser Asp Lys Asn Lys 
    130                 135                 140                 


Thr Tyr Ser Val Glu Tyr Leu Pro Lys Val Thr Gly Leu His Lys Val 
145                 150                 155                 160 


Thr Val Leu Phe Ala Gly Gln His Ile Ser Lys Ser Pro Phe Glu Val 
                165                 170                 175     


Ser Val Asp Lys Ala Gln Gly Asp Ala Ser Lys Val Thr Ala Lys Gly 
            180                 185                 190         


Pro Gly Leu Glu Ala Val Gly Asn Ile Ala Asn Lys Pro Thr Tyr Phe 
        195                 200                 205             


Asp Ile Tyr Thr Ala Gly Ala Gly Val Gly Asp Ile Gly Val Glu Val 
    210                 215                 220                 


Glu Asp Pro Gln Gly Lys Asn Thr Val Glu Leu Leu Val Glu Asp Lys 
225                 230                 235                 240 


Gly Asn Gln Val Tyr Arg Cys Val Tyr Lys Pro Met Gln Pro Gly Pro 
                245                 250                 255     


His Val Val Lys Ile Phe Phe Ala Gly Asp Thr Ile Pro Lys Ser Pro 
            260                 265                 270         


Phe Val Val Gln Val Gly Glu Ala Cys Asn Pro Asn Ala Cys Arg Ala 
        275                 280                 285             


Ser Gly Arg Gly Leu Gln Pro Lys Gly Val Arg Ile Arg Glu Thr Thr 
    290                 295                 300                 


Asp Phe Lys Val Asp Thr Lys Ala Ala Gly Ser Gly Glu Leu Gly Val 
305                 310                 315                 320 


Thr Met Lys Gly Pro Lys Gly Leu Glu Glu Leu Val Lys Gln Lys Asp 
                325                 330                 335     


Phe Leu Asp Gly Val Tyr Ala Phe Glu Tyr Tyr Pro Ser Thr Pro Gly 
            340                 345                 350         


Arg Tyr Ser Ile Ala Ile Thr Trp Gly Gly His His Ile Pro Lys Ser 
        355                 360                 365             


Pro Phe Glu Val Gln Val Gly Pro Glu Ala Gly Met Gln Lys Val Arg 
    370                 375                 380                 


Ala Trp Gly Pro Gly Leu His Gly Gly Ile Val Gly Arg Ser Ala Asp 
385                 390                 395                 400 


Phe Val Val Glu Ser Ile Gly Ser Glu Val Gly Ser Leu Gly Phe Ala 
                405                 410                 415     


Ile Glu Gly Pro Ser Gln Ala Lys Ile Glu Tyr Asn Asp Gln Asn Asp 
            420                 425                 430         


Gly Ser Cys Asp Val Lys Tyr Trp Pro Lys Glu Pro Gly Glu Tyr Ala 
        435                 440                 445             


Val His Ile Met Cys Asp Asp Glu Asp Ile Lys Asp Ser Pro Tyr Met 
    450                 455                 460                 


Ala Phe Ile His Pro Ala Thr Gly Gly Tyr Asn Pro Asp Leu Val Arg 
465                 470                 475                 480 


Ala Tyr Gly Pro Gly Leu Glu Lys Ser Gly Cys Ile Val Asn Asn Leu 
                485                 490                 495     


Ala Glu Phe Thr Val Asp Pro Lys Asp Ala Gly Lys Ala Pro Leu Lys 
            500                 505                 510         


Ile Phe Ala Gln Asp Gly Glu Gly Gln Arg Ile Asp Ile Gln Met Lys 
        515                 520                 525             


Asn Arg Met Asp Gly Thr Tyr Ala Cys Ser Tyr Thr Pro Val Lys Ala 
    530                 535                 540                 


Ile Lys His Thr Ile Ala Val Val Trp Gly Gly Val Asn Ile Pro His 
545                 550                 555                 560 


Ser Pro Tyr Arg Val Asn Ile Gly Gln Gly Ser His Pro Gln Lys Val 
                565                 570                 575     


Lys Val Phe Gly Pro Gly Val Glu Arg Ser Gly Leu Lys Ala Asn Glu 
            580                 585                 590         


Pro Thr His Phe Thr Val Asp Cys Thr Glu Ala Gly Glu Gly Asp Val 
        595                 600                 605             


Ser Val Gly Ile Lys Cys Asp Ala Arg Val Leu Ser Glu Asp Glu Glu 
    610                 615                 620                 


Asp Val Asp Phe Asp Ile Ile His Asn Ala Asn Asp Thr Phe Thr Val 
625                 630                 635                 640 


Lys Tyr Val Pro Pro Ala Ala Gly Arg Tyr Thr Ile Lys Val Leu Phe 
                645                 650                 655     


Ala Ser Gln Glu Ile Pro Ala Ser Pro Phe Arg Val Lys Val Asp Pro 
            660                 665                 670         


Ser His Asp Ala Ser Lys Val Lys Ala Glu Gly Pro Gly Leu Ser Lys 
        675                 680                 685             


Ala Gly Val Glu Asn Gly Lys Pro Thr His Phe Thr Val Tyr Thr Lys 
    690                 695                 700                 


Gly Ala Gly Lys Ala Pro Leu Asn Val Gln Phe Asn Ser Pro Leu Pro 
705                 710                 715                 720 


Gly Asp Ala Val Lys Asp Leu Asp Ile Ile Asp Asn Tyr Asp Tyr Ser 
                725                 730                 735     


His Thr Val Lys Tyr Thr Pro Thr Gln Gln Gly Asn Met Gln Val Leu 
            740                 745                 750         


Val Thr Tyr Gly Gly Asp Pro Ile Pro Lys Ser Pro Phe Thr Val Gly 
        755                 760                 765             


Val Ala Ala Pro Leu Asp Leu Ser Lys Ile Lys Leu Asn Gly Leu Glu 
    770                 775                 780                 


Asn Arg Val Glu Val Gly Lys Asp Gln Glu Phe Thr Val Asp Thr Arg 
785                 790                 795                 800 


Gly Ala Gly Gly Gln Gly Lys Leu Asp Val Thr Ile Leu Ser Pro Ser 
                805                 810                 815     


Arg Lys Val Val Pro Cys Leu Val Thr Pro Val Thr Gly Arg Glu Asn 
            820                 825                 830         


Ser Thr Ala Lys Phe Ile Pro Arg Glu Glu Gly Leu Tyr Ala Val Asp 
        835                 840                 845             


Val Thr Tyr Asp Gly His Pro Val Pro Gly Ser Pro Tyr Thr Val Glu 
    850                 855                 860                 


Ala Ser Leu Pro Pro Asp Pro Ser Lys Val Lys Ala His Gly Pro Gly 
865                 870                 875                 880 


Leu Glu Gly Gly Leu Val Gly Lys Pro Ala Glu Phe Thr Ile Asp Thr 
                885                 890                 895     


Lys Gly Ala Gly Thr Gly Gly Leu Gly Leu Thr Val Glu Gly Pro Cys 
            900                 905                 910         


Glu Ala Lys Ile Glu Cys Ser Asp Asn Gly Asp Gly Thr Cys Ser Val 
        915                 920                 925             


Ser Tyr Leu Pro Thr Lys Pro Gly Glu Tyr Phe Val Asn Ile Leu Phe 
    930                 935                 940                 


Glu Glu Val His Ile Pro Gly Ser Pro Phe Lys Ala Asp Ile Glu Met 
945                 950                 955                 960 


Pro Phe Asp Pro Ser Lys Val Val Ala Ser Gly Pro Gly Leu Glu His 
                965                 970                 975     


Gly Lys Val Gly Glu Ala Gly Leu Leu Ser Val Asp Cys Ser Glu Ala 
            980                 985                 990         


Gly Pro Gly Ala Leu Gly Leu Glu  Ala Val Ser Asp Ser  Gly Thr Lys 
        995                 1000                 1005             


Ala Glu  Val Ser Ile Gln Asn  Asn Lys Asp Gly Thr  Tyr Ala Val 
    1010                 1015                 1020             


Thr Tyr  Val Pro Leu Thr Ala  Gly Met Tyr Thr Leu  Thr Met Lys 
    1025                 1030                 1035             


Tyr Gly  Gly Glu Leu Val Pro  His Phe Pro Ala Arg  Val Lys Val 
    1040                 1045                 1050             


Glu Pro  Ala Val Asp Thr Ser  Arg Ile Lys Val Phe  Gly Pro Gly 
    1055                 1060                 1065             


Ile Glu  Gly Lys Asp Val Phe  Arg Glu Ala Thr Thr  Asp Phe Thr 
    1070                 1075                 1080             


Val Asp  Ser Arg Pro Leu Thr  Gln Val Gly Gly Asp  His Ile Lys 
    1085                 1090                 1095             


Ala His  Ile Ala Asn Pro Ser  Gly Ala Ser Thr Glu  Cys Phe Val 
    1100                 1105                 1110             


Thr Asp  Asn Ala Asp Gly Thr  Tyr Gln Val Glu Tyr  Thr Pro Phe 
    1115                 1120                 1125             


Glu Lys  Gly Leu His Val Val  Glu Val Thr Tyr Asp  Asp Val Pro 
    1130                 1135                 1140             


Ile Pro  Asn Ser Pro Phe Lys  Val Ala Val Thr Glu  Gly Cys Gln 
    1145                 1150                 1155             


Pro Ser  Arg Val Gln Ala Gln  Gly Pro Gly Leu Lys  Glu Ala Phe 
    1160                 1165                 1170             


Thr Asn  Lys Pro Asn Val Phe  Thr Val Val Thr Arg  Gly Ala Gly 
    1175                 1180                 1185             


Ile Gly  Gly Leu Gly Ile Thr  Val Glu Gly Pro Ser  Glu Ser Lys 
    1190                 1195                 1200             


Ile Asn  Cys Arg Asp Asn Lys  Asp Gly Ser Cys Ser  Ala Glu Tyr 
    1205                 1210                 1215             


Ile Pro  Phe Ala Pro Gly Asp  Tyr Asp Val Asn Ile  Thr Tyr Gly 
    1220                 1225                 1230             


Gly Ala  His Ile Pro Gly Ser  Pro Phe Arg Val Pro  Val Lys Asp 
    1235                 1240                 1245             


Val Val  Asp Pro Ser Lys Val  Lys Ile Ala Gly Pro  Gly Leu Gly 
    1250                 1255                 1260             


Ser Gly  Val Arg Ala Arg Val  Leu Gln Ser Phe Thr  Val Asp Ser 
    1265                 1270                 1275             


Ser Lys  Ala Gly Leu Ala Pro  Leu Glu Val Arg Val  Leu Gly Pro 
    1280                 1285                 1290             


Arg Gly  Leu Val Glu Pro Val  Asn Val Val Asp Asn  Gly Asp Gly 
    1295                 1300                 1305             


Thr His  Thr Val Thr Tyr Thr  Pro Ser Gln Glu Gly  Pro Tyr Met 
    1310                 1315                 1320             


Val Ser  Val Lys Tyr Ala Asp  Glu Glu Ile Pro Arg  Ser Pro Phe 
    1325                 1330                 1335             


Lys Val  Lys Val Leu Pro Thr  Tyr Asp Ala Ser Lys  Val Thr Ala 
    1340                 1345                 1350             


Ser Gly  Pro Gly Leu Ser Ser  Tyr Gly Val Pro Ala  Ser Leu Pro 
    1355                 1360                 1365             


Val Asp  Phe Ala Ile Asp Ala  Arg Asp Ala Gly Glu  Gly Leu Leu 
    1370                 1375                 1380             


Ala Val  Gln Ile Thr Asp Gln  Glu Gly Lys Pro Lys  Arg Ala Ile 
    1385                 1390                 1395             


Val His  Asp Asn Lys Asp Gly  Thr Tyr Ala Val Thr  Tyr Ile Pro 
    1400                 1405                 1410             


Asp Lys  Thr Gly Arg Tyr Met  Ile Gly Val Thr Tyr  Gly Gly Asp 
    1415                 1420                 1425             


Asp Ile  Pro Leu Ser Pro Tyr  Arg Ile Arg Ala Thr  Gln Thr Gly 
    1430                 1435                 1440             


Asp Ala  Ser Lys Cys Leu Ala  Thr Gly Pro Gly Ile  Ala Ser Thr 
    1445                 1450                 1455             


Val Lys  Thr Gly Glu Glu Val  Gly Phe Val Val Asp  Ala Lys Thr 
    1460                 1465                 1470             


Ala Gly  Lys Gly Lys Val Thr  Cys Thr Val Leu Thr  Pro Asp Gly 
    1475                 1480                 1485             


Thr Glu  Ala Glu Ala Asp Val  Ile Glu Asn Glu Asp  Gly Thr Tyr 
    1490                 1495                 1500             


Asp Ile  Phe Tyr Thr Ala Ala  Lys Pro Gly Thr Tyr  Val Ile Tyr 
    1505                 1510                 1515             


Val Arg  Phe Gly Gly Val Asp  Ile Pro Asn Ser Pro  Phe Thr Val 
    1520                 1525                 1530             


Met Val  Thr Glu Glu Ala Tyr  Val Pro Val Ser Asp  Met Asn Gly 
    1535                 1540                 1545             


Leu Gly  Phe Lys Pro Phe Asp  Leu Val Ile Pro Phe  Ala Val Arg 
    1550                 1555                 1560             


Lys Gly  Glu Ile Thr Gly Glu  Val His Met Pro Ser  Gly Lys Thr 
    1565                 1570                 1575             


Ala Thr  Pro Glu Ile Val Asp  Asn Lys Asp Gly Thr  Val Thr Val 
    1580                 1585                 1590             


Arg Tyr  Ala Pro Thr Glu Val  Gly Leu His Glu Met  His Ile Lys 
    1595                 1600                 1605             


Tyr Met  Gly Ser His Ile Pro  Glu Ser Pro Leu Gln  Phe Tyr Val 
    1610                 1615                 1620             


Asn Tyr  Pro Asn Ser Gly Ser  Val Ser Ala Tyr Gly  Pro Gly Leu 
    1625                 1630                 1635             


Val Tyr  Gly Val Ala Asn Lys  Thr Ala Thr Phe Thr  Ile Val Thr 
    1640                 1645                 1650             


Glu Asp  Ala Gly Glu Gly Gly  Leu Asp Leu Ala Ile  Glu Gly Pro 
    1655                 1660                 1665             


Ser Lys  Ala Glu Ile Ser Cys  Ile Asp Asn Lys Asp  Gly Thr Cys 
    1670                 1675                 1680             


Thr Val  Thr Tyr Leu Pro Thr  Leu Pro Gly Asp Tyr  Ser Ile Leu 
    1685                 1690                 1695             


Val Lys  Tyr Asn Asp Lys His  Ile Pro Gly Ser Pro  Phe Thr Ala 
    1700                 1705                 1710             


Lys Ile  Thr Asp Asp Ser Arg  Arg Cys Ser Gln Val  Lys Leu Gly 
    1715                 1720                 1725             


Ser Ala  Ala Asp Phe Leu Leu  Asp Ile Ser Glu Thr  Asp Leu Ser 
    1730                 1735                 1740             


Ser Leu  Thr Ala Ser Ile Lys  Ala Pro Ser Gly Arg  Asp Glu Pro 
    1745                 1750                 1755             


Cys Leu  Leu Lys Arg Leu Pro  Asn Asn His Ile Gly  Ile Ser Phe 
    1760                 1765                 1770             


Ile Pro  Arg Glu Val Gly Glu  His Leu Val Ser Ile  Lys Lys Asn 
    1775                 1780                 1785             


Gly Asn  His Val Ala Asn Ser  Pro Val Ser Ile Met  Val Val Gln 
    1790                 1795                 1800             


Ser Glu  Ile Gly Asp Ala Arg  Arg Ala Lys Val Tyr  Gly Arg Gly 
    1805                 1810                 1815             


Leu Ser  Glu Gly Arg Thr Phe  Glu Met Ser Asp Phe  Ile Val Asp 
    1820                 1825                 1830             


Thr Arg  Asp Ala Gly Tyr Gly  Gly Ile Ser Leu Ala  Val Glu Gly 
    1835                 1840                 1845             


Pro Ser  Lys Val Asp Ile Gln  Thr Glu Asp Leu Glu  Asp Gly Thr 
    1850                 1855                 1860             


Cys Lys  Val Ser Tyr Phe Pro  Thr Val Pro Gly Val  Tyr Ile Val 
    1865                 1870                 1875             


Ser Thr  Lys Phe Ala Asp Glu  His Val Pro Gly Ser  Pro Phe Thr 
    1880                 1885                 1890             


Val Lys  Ile Ser Gly Glu Gly  Arg Val Lys Glu Ser  Ile Thr Arg 
    1895                 1900                 1905             


Thr Ser  Arg Ala Pro Ser Val  Ala Thr Val Gly Ser  Ile Cys Asp 
    1910                 1915                 1920             


Leu Asn  Leu Lys Ile Pro Glu  Ile Asn Ser Ser Asp  Met Ser Ala 
    1925                 1930                 1935             


His Val  Thr Ser Pro Ser Gly  Arg Val Thr Glu Ala  Glu Ile Val 
    1940                 1945                 1950             


Pro Met  Gly Lys Asn Ser His  Cys Val Arg Phe Val  Pro Gln Glu 
    1955                 1960                 1965             


Met Gly  Val His Thr Val Ser  Val Lys Tyr Arg Gly  Gln His Val 
    1970                 1975                 1980             


Thr Gly  Ser Pro Phe Gln Phe  Thr Val Gly Pro Leu  Gly Glu Gly 
    1985                 1990                 1995             


Gly Ala  His Lys Val Arg Ala  Gly Gly Pro Gly Leu  Glu Arg Gly 
    2000                 2005                 2010             


Glu Ala  Gly Val Pro Ala Glu  Phe Ser Ile Trp Thr  Arg Glu Ala 
    2015                 2020                 2025             


Gly Ala  Gly Gly Leu Ser Ile  Ala Val Glu Gly Pro  Ser Lys Ala 
    2030                 2035                 2040             


Glu Ile  Thr Phe Asp Asp His  Lys Asn Gly Ser Cys  Gly Val Ser 
    2045                 2050                 2055             


Tyr Ile  Ala Gln Glu Pro Gly  Asn Tyr Glu Val Ser  Ile Lys Phe 
    2060                 2065                 2070             


Asn Asp  Glu His Ile Pro Glu  Ser Pro Tyr Leu Val  Pro Val Ile 
    2075                 2080                 2085             


Ala Pro  Ser Asp Asp Ala Arg  Arg Leu Thr Val Met  Ser Leu Gln 
    2090                 2095                 2100             


Glu Ser  Gly Leu Lys Val Asn  Gln Pro Ala Ser Phe  Ala Ile Arg 
    2105                 2110                 2115             


Leu Asn  Gly Ala Lys Gly Lys  Ile Asp Ala Lys Val  His Ser Pro 
    2120                 2125                 2130             


Ser Gly  Ala Val Glu Glu Cys  His Val Ser Glu Leu  Glu Pro Asp 
    2135                 2140                 2145             


Lys Tyr  Ala Val Arg Phe Ile  Pro His Glu Asn Gly  Val His Thr 
    2150                 2155                 2160             


Ile Asp  Val Lys Phe Asn Gly  Ser His Val Val Gly  Ser Pro Phe 
    2165                 2170                 2175             


Lys Val  Arg Val Gly Glu Pro  Gly Gln Ala Gly Asn  Pro Ala Leu 
    2180                 2185                 2190             


Val Ser  Ala Tyr Gly Thr Gly  Leu Glu Gly Gly Thr  Thr Gly Ile 
    2195                 2200                 2205             


Gln Ser  Glu Phe Phe Ile Asn  Thr Thr Arg Ala Gly  Pro Gly Thr 
    2210                 2215                 2220             


Leu Ser  Val Thr Ile Glu Gly  Pro Ser Lys Val Lys  Met Asp Cys 
    2225                 2230                 2235             


Gln Glu  Thr Pro Glu Gly Tyr  Lys Val Met Tyr Thr  Pro Met Ala 
    2240                 2245                 2250             


Pro Gly  Asn Tyr Leu Ile Ser  Val Lys Tyr Gly Gly  Pro Asn His 
    2255                 2260                 2265             


Ile Val  Gly Ser Pro Phe Lys  Ala Lys Val Thr Gly  Gln Arg Leu 
    2270                 2275                 2280             


Val Ser  Pro Gly Ser Ala Asn  Glu Thr Ser Ser Ile  Leu Val Glu 
    2285                 2290                 2295             


Ser Val  Thr Arg Ser Ser Thr  Glu Thr Cys Tyr Ser  Ala Ile Pro 
    2300                 2305                 2310             


Lys Ala  Ser Ser Asp Ala Ser  Lys Val Thr Ser Lys  Gly Ala Gly 
    2315                 2320                 2325             


Leu Ser  Lys Ala Phe Val Gly  Gln Lys Ser Ser Phe  Leu Val Asp 
    2330                 2335                 2340             


Cys Ser  Lys Ala Gly Ser Asn  Met Leu Leu Ile Gly  Val His Gly 
    2345                 2350                 2355             


Pro Thr  Thr Pro Cys Glu Glu  Val Ser Met Lys His  Val Gly Asn 
    2360                 2365                 2370             


Gln Gln  Tyr Asn Val Thr Tyr  Val Val Lys Glu Arg  Gly Asp Tyr 
    2375                 2380                 2385             


Val Leu  Ala Val Lys Trp Gly  Glu Glu His Ile Pro  Gly Ser Pro 
    2390                 2395                 2400             


Phe His  Val Thr Val Pro 
    2405                 

<210>  1593
<211>  478
<212>  DNA
<213>  Homo sapiens

<400>  1593
atcatttagg tgggagagag gatgttagta aattaaaaga aaaaggttat tcattaaatg     60

ctaaatagta taggatgtac aggccagaaa agaaaaagga agtccacgag tgaggaaagg    120

ttggaaaaca atagtagaat taggaaagct attcaaaatg ctctcttatg taaaaaagag    180

ctttgcttag gaatatgtta gaattttttt tgcctgtttt ttgactaaga cttgagagtt    240

ctttctacat gttctagata ctagtgttct gttggacata tggtttgcaa attttttctc    300

ccagtcttta gcctgtatat tcatcctctt aactgtaaaa agttttaaat tgtttgtaaa    360

agtaaaatcc agcccccaga tcccagtctc agcaacattt tgagttctgt ttgagacggt    420

gtccgggtgg cttttatagt gtgagggcta agacagcttg tcttgcagga cagtaggt      478


<210>  1594
<211>  47
<212>  PRT
<213>  Homo sapiens

<400>  1594


Met Leu Asn Ser Ile Gly Cys Thr Gly Gln Lys Arg Lys Arg Lys Ser 
1               5                   10                  15      


Thr Ser Glu Glu Arg Leu Glu Asn Asn Ser Arg Ile Arg Lys Ala Ile 
            20                  25                  30          


Gln Asn Ala Leu Leu Cys Lys Lys Glu Leu Cys Leu Gly Ile Cys 
        35                  40                  45          

<210>  1595
<211>  1915
<212>  DNA
<213>  Homo sapiens

<400>  1595
cattatgtgt ttcagcattt gtgagggggt gggttgctct ggatgtggca gatggtgggg     60

tttggaggtg ataactcatt gagatatctt ggtgtccatg tggtacatac cagaacctct    120

gggaatgcca ggcacatgat gcacgtgata cgtggctttg tcattgtctt agttccccag    180

agagagagtg tgtcttgggg aatgggcttt gttggcaatt tggcctgcct tgttggcagc    240

ttggaacttg ggtttggtaa ggctagcggg ccatataggg acaaagccct gaagtgcatt    300

ggaacttgcc ttttttgata agtgaccatg tttcctcctc cagcacttaa aatgtgcctt    360

tctcccacat agaggacagt gtgcctaatt tcttacgtaa tctggatttt cctcgccaat    420

gatatgttct tggattcaca gaagtggcaa atggggtttt ccctctttga agaggaacct    480

tctccttcat ggggttcagc aggaggtttt atcttttgaa gctcagggca gaaatggttt    540

gggggaaatt aggtcatggg tctgggatca gattctgtga agttactgag cttcaggacc    600

tgcatgtgtt tgtgtgcatg tatgtgtccc tgtgtatgtg tgaatgagag agggagaaaa    660

agaagaaaga gaagctttac ttggatatct gcctctatta tgaaggactc tcaagtaaca    720

gccttttgat tttagctgac gacacggatt cccagtcatg gcgcagcccc ttgaaagccc    780

tttcagagtt ctttaaaggt gacccgaagg gtgactttaa taagacaggt ttgcattttc    840

ccatggctgc tgaattatgt aacccaaatg cttcttgctg gcctcacttc taaaattgct    900

tacacctgcc tcatctgctt tgcttaatga gcatgccatc ctttgattaa cctaccctgg    960

agttgaccca tccttgactg tcacgttgga agctgggatc tggactctgc aacccaacgc   1020

gtgccttgat tatgttttag cataatctct aacatctcca caggcttcac cttgagggtc   1080

cccttgcccc atgagattgg caccctcacc tgccctgcac ctatgcccca gcatgctggt   1140

accacagtgt tctttgctca aaggtggcca caagtcttga ctagccagcc cattggttaa   1200

tttttgctct tcacaattct ggactctttg gcagtgtctc agctgtagag taaaattgcc   1260

acatcctaag cgtgcctaac cagcttgaaa ggttatattg tgtcttcaac acacatcatc   1320

cacatacacc ctccagcagc aagcacaggc agtctcctta attatactct agggcagact   1380

gagtgtattt tagccaacaa aaagctaaag gtgtctctcg gggtcatttc tgcaaccatg   1440

aattggggat cctgtgattt ttttcaggcc tgtgattatg gttgctggcc tttttgttac   1500

tcatcagtgg aaaccaatag ctcttgggga tggatgtggt cctatttcag actcagccaa   1560

gggtggagta aaggtgaggc caggcagctc cttaaacctc tcatctctgt cctcaggctt   1620

ggtggagcca gtgaacgtgg tggacaatgg agatggcaca cacacagtaa cctacacccc   1680

atctcaggag ggaccttaca tggtctcagt taaatatgct gatgaagaga ttcctcgcag   1740

gtaagcagtc cgtctaccca ttcatagagg cagcaagtat tacatagaac ctgcaacttg   1800

tcaccacaca ctagccttga tatttgtggc tcccgctctc tcactccccc agttcctttc   1860

agacatcttt agtttaaagg tgagctgaaa ttaagaagtt ggaaatccta accac        1915


<210>  1596
<211>  91
<212>  PRT
<213>  Homo sapiens

<400>  1596


Met Trp Gln Met Val Gly Phe Gly Gly Asp Asn Ser Leu Arg Tyr Leu 
1               5                   10                  15      


Gly Val His Val Val His Thr Arg Thr Ser Gly Asn Ala Arg His Met 
            20                  25                  30          


Met His Val Ile Arg Gly Phe Val Ile Val Leu Val Pro Gln Arg Glu 
        35                  40                  45              


Ser Val Ser Trp Gly Met Gly Phe Val Gly Asn Leu Ala Cys Leu Val 
    50                  55                  60                  


Gly Ser Leu Glu Leu Gly Phe Gly Lys Ala Ser Gly Pro Tyr Arg Asp 
65                  70                  75                  80  


Lys Ala Leu Lys Cys Ile Gly Thr Cys Leu Phe 
                85                  90      

<210>  1597
<211>  6889
<212>  DNA
<213>  Homo sapiens

<400>  1597
gcaggaggtt ttatcttttg aagctcaggg cagaaatggt ttgggggaaa ttaggtcatg     60

ggtctgggat cagattctgt gaagttactg agcttcagga cctgcatgtg tttgtgtgca    120

tgtatgtgtc cctgtgtatg tgtgaatgag agagggagaa aaagaagaaa gagaagcttt    180

acttggatat ctgcctctat tatgaaggac tctcaagtaa cagccttttg attttagctg    240

acgacacgga ttcccagtca tggcgcagcc ccttgaaagc cctttcagag ttctttaaag    300

gtgacccgaa gggtgacttt aataagacag gtttgcattt tcccatggct gctgaattat    360

gtaacccaaa tgcttcttgc tggcctcact tctaaaattg cttacacctg cctcatctgc    420

tttgcttaat gagcatgcca tcctttgatt aacctaccct ggagttgacc catccttgac    480

tgtcacgttg gaagctggga tctggactct gcaacccaac gcgtgccttg attatgtttt    540

agcataatct ctaacatctc cacaggcttc accttgaggg tccccttgcc ccatgagatt    600

ggcaccctca cctgccctgc acctatgccc cagcatgctg gtaccacagt gttctttgct    660

caaaggtggc cacaagtctt gactagccag cccattggtt aatttttgct cttcacaatt    720

ctggactctt tggcagtgtc tcagctgtag agtaaaattg ccacatccta agcgtgccta    780

accagcttga aaggttatat tgtgtcttca acacacatca tccacataca ccctccagca    840

gcaagcacag gcagtctcct taattatact ctagggcaga ctgagtgtat tttagccaac    900

aaaaagctaa aggtgtctct cggggtcatt tctgcaacca tgaattgggg atcctgtgat    960

ttttttcagg cctgtgatta tggttgctgg cctttttgtt actcatcagt ggaaaccaat   1020

agctcttggg gatggatgtg gtcctatttc agactcagcc aagggtggag taaaggtgag   1080

gccaggcagc tccttaaacc tctcatctct gtcctcaggc ttggtggagc cagtgaacgt   1140

ggtggacaat ggagatggca cacacacagt aacctacacc ccatctcagg agggacctta   1200

catggtctca gttaaatatg ctgatgaaga gattcctcgc agtcccttca aggtcaaggt   1260

ccttcccaca tatgatgcca gcaaagtgac tgccagtggc cccggcctta gttcctatgg   1320

tgtgcctgcc agtctacctg tggactttgc aattgatgcc cgagatgccg gggaaggcct   1380

gcttgctgtt caaataacgg accaagaagg aaaacccaaa agagccattg tccatgacaa   1440

taaagatggc acgtatgctg tcacctacat ccccgacaag actgggcgct atatgattgg   1500

agtcacctac gggggtgacg acatcccact ttctccttat cgcatccgag ccacacagac   1560

gggtgatgcc agcaagtgcc tggccacggg tcctggaatc gcctccactg tgaaaactgg   1620

cgaagaagta ggctttgtgg ttgatgccaa gactgccggg aagggtaaag tgacctgcac   1680

ggttctgacc ccagatggca ctgaggccga ggccgatgtc attgagaatg aagatggaac   1740

ctatgacatc ttctacacag ctgccaagcc gggcacatat gtgatctatg tgcgcttcgg   1800

tggtgttgat attcctaaca gccccttcac tgtcatggtg accgaagagg cctatgtccc   1860

agtgagtgac atgaacggcc tgggatttaa gccttttgac ctggtcattc cgtttgctgt   1920

caggaaagga gaaatcactg gagaggtcca catgccttct gggaagacag ccacacctga   1980

gattgtggac aacaaggacg gcacggtcac tgttagatat gcccccactg aggtcgggct   2040

ccatgagatg cacatcaaat acatgggcag ccacatccct gagagcccac tccagttcta   2100

cgtgaactac cccaacagtg gaagtgtttc tgcatacggt ccaggcctcg tgtatggagt   2160

ggccaacaaa actgccacct tcaccatcgt cacagaggat gcaggagaag gtggtctgga   2220

cttggctatt gagggcccct caaaagcaga aatcagctgc attgacaata aagatgggac   2280

atgcacagtg acctacctgc cgactctgcc aggcgactac agcattctgg tcaagtacaa   2340

tgacaagcac atccctggca gccccttcac agccaagatc acagatgaca gcaggcggtg   2400

ctcccaggtg aagttgggct cagccgctga cttcctgctc gacatcagtg agactgacct   2460

cagcagcctg acggccagca ttaaggcccc atctggccga gacgagccct gtctcctgaa   2520

gaggctgccc aacaaccaca ttggcatctc cttcatcccc cgggaagtgg gcgaacatct   2580

ggtcagcatc aagaaaaatg gcaaccatgt ggccaacagc cccgtgtcta tcatggtggt   2640

ccagtcggag attggtgacg cccgccgagc caaagtctat ggccgcggcc tgtcagaagg   2700

ccggactttc gagatgtctg acttcatcgt ggacacaagg gatgcaggtt atggtggcat   2760

atccttggcg gtggaaggcc ccagcaaagt ggacatccag acggaggacc tggaagatgg   2820

cacctgcaaa gtctcctact tccctaccgt gcctggggtt tatatcgtct ccaccaaatt   2880

cgctgacgag cacgtgcctg ggagcccatt taccgtgaag atcagtgggg agggaagagt   2940

caaagagagc atcacccgca ccagtcgggc cccgtccgtg gccactgtcg ggagcatttg   3000

tgacctgaac ctgaaaatcc cagaaatcaa cagcagtgat atgtcggccc acgtcaccag   3060

cccctctggc cgtgtgactg aggcagagat tgtgcccatg gggaagaact cacactgcgt   3120

ccggtttgtg ccccaggaga tgggcgtgca cacggtcagc gtcaagtacc gtgggcagca   3180

cgtcaccggc agccccttcc agttcaccgt ggggccactt ggtgaaggag gcgcccacaa   3240

ggtgcgggca ggaggccctg gcctggagag aggagaagcg ggagtcccag ctgagttcag   3300

catttggacc cgggaagcag gcgctggagg cctctccatc gctgttgagg gccccagtaa   3360

ggccgagatt acattcgatg accataaaaa tgggtcgtgc ggtgtatctt atattgccca   3420

agagcctggt aactacgagg tgtccatcaa gttcaatgat gagcacatcc cggaaagccc   3480

ctacctggtg ccggtcatcg caccctccga cgacgcccgc cgcctcactg ttatgagcct   3540

tcaggaatcg ggattaaaag ttaaccagcc agcatccttt gctataaggt tgaatggcgc   3600

aaaaggcaag attgatgcaa aggtgcacag cccctctgga gccgtggagg agtgccacgt   3660

gtctgagctg gagccagata agtatgctgt tcgcttcatc cctcatgaga atggtgtcca   3720

caccatcgat gtcaagttca atgggagcca cgtggttgga agccccttca aagtgcgcgt   3780

tggggagcct ggacaagcgg ggaaccctgc cctggtgtcc gcctatggca cgggactcga   3840

agggggcacc acaggtatcc agtcggaatt ctttattaac accacccgag caggtccagg   3900

gacattatcc gtcaccatcg aaggcccatc caaggttaaa atggattgcc aggaaacacc   3960

tgaagggtac aaagtcatgt acacccccat ggctcctggt aactacctga tcagcgtcaa   4020

atacggtggg cccaaccaca tcgtgggcag tcccttcaag gccaaggtga caggtaacga   4080

acaaccacct tcggagttac tctcccttcc tggggagctg gttgtgtcag atcaatcata   4140

gtggaaacta tggatggttt tagatgtgtt aaagctactt tgaactttga atgtcagtaa   4200

atagtatgag atgtcagagg gcagtgtttg aaacttacaa aagtccacag agtggagccg   4260

tgcagaagtt gagaaagcat gttaggatgt taggtggttt tctatctcta acaggaaaga   4320

atacatattg aaatcttacg tatttgttta gatcagggtc tgaaaaatcc cctgatttct   4380

aattttcact tgaaaaataa tcaaaaagtt ttcctatact tataaaaatg tgtctcctcc   4440

aaaacactgg aaaaaatacc aaactatgaa aaccacttca cagccaccac ccaaggtaac   4500

caccataaac actgtagtaa atcccttcca cacgtcatga ttcactgtta cataaagaat   4560

gtaggttcat cgcaggaaaa ttagaaaatt cagatagaaa aatcatcctt tctcatccac   4620

agaatcattt tttgatattt cattatatgt catcccaaac ttttacactg cttatacata   4680

gactatttta tgtcaataga aagatgtgaa ttccacaggc acatctttgg tgggtagggg   4740

gtggggggat tgggagggtc cttggccttg tcagccaagg ccagactcat ccatttgccc   4800

agaaagccag atcctagttg tatgggggtg ggatcctagg ggtttagaag acattatggg   4860

tgtgagatac aggtgtggtg gcttttgtgt tggggtgcgc gggctctcct ggggttactg   4920

tgtagggtac tcgcctgtcc tctggctgag agacccctct tgatctggcc attcatgcct   4980

gtccccctcc ctcctgtatc ttaggccagc gtctagttag ccctggctca gccaacgaga   5040

cctcatccat cctggtggag tcagtgacca ggtcgtctac agagacctgc tatagcgcca   5100

ttcccaaggc atcctcggac gccagcaagg tgacctctaa gggggcaggg ctctcaaagg   5160

cctttgtggg ccagaagagt tccttcctgg tggactgcag caaagctggc tccaacatgc   5220

tgctgatcgg ggtccatggg cccaccaccc cctgcgagga ggtctccatg aagcatgtag   5280

gcaaccagca atacaacgtc acatacgtcg tcaaggagag gggcgattat gtgctggctg   5340

tgaagtgggg ggaggaacac atccctggca gcccttttca tgtcacagtg ccttaaaaca   5400

gttttctcaa atcctggaga gagttcttgt ggttgctttt gttgcttgtt tgtaattcat   5460

tttatacaaa gccctccagc ctgtttgtgg ggctgaaacc ccatccctaa aatattgctg   5520

ttgtaaaatg ccttcagaaa taagtcctag actggactct tgagggacat attggagaat   5580

cttaagaaat gcaagcttgt tcagggggct gagaagatcc tgagtacact aggtgcaaac   5640

cagaactctt ggtggaacag accagccact gcagcagaca gaccaggaac acaatgagac   5700

tgacatttca aaaaaacaaa actggctagc ctgagctgct ggttcactct tcagcattta   5760

tgaaacaagg ctaggggaag atgggcagag aaaaagggga cacctagttt ggttgtcatt   5820

tggcaaagga gatgacttaa aatccgctta atctcttcca gtgtccgtgt taatgtattt   5880

ggctattaga tcactagcac tgctttaccg ctcctcatcg ccaacacccc catgctctgt   5940

ggccttctta cacttctcag agggcagagt ggcagccggg caccctacag aaactcagag   6000

ggcagagtgg cagccaggcc cacatgtctc tcaagtacct gtcccctcgc tctggtgatt   6060

atttcttgca gaatcaccac acgagaccat cccggcagtc atggttttgc tttagttttc   6120

caagtccgtt tcagtccctt ccttggtctg aagaaattct gcagtggcga gcagtttccc   6180

acttgccaaa gatccctttt aaccaacact agcccttgtt tttaacacac gctccagccc   6240

ttcatcagcc tgggcagtct taccaaaatg tttaaagtga tctcagaggg gcccatggat   6300

taacgccctc atcccaaggt ccgtcccatg acataacact ccacacccgc cccagccaac   6360

ttcatgggtc actttttctg gaaaataatg atctgtacag acaggacaga atgaaactcc   6420

tgcgggtctt tggcctgaaa gttgggaatg gttgggggag agaagggcag cagcttattg   6480

gtggtctttt caccattggc agaaacagtg agagctgtgt ggtgcagaaa tccagaaatg   6540

aggtgtaggg aattttgcct gccttcctgc agacctgagc tggctttgga atgaggttaa   6600

agtgtcaggg acgttgcctg agcccaaatg tgtagtgtgg tctgggcagg cagaccttta   6660

ggttttgctg cttagtcctg aggaagtggc cactcttgtg gcaggtgtag tatctggggc   6720

gagtgttggg ggtaaaagcc caccctacag aaagtggaac agcccggagc ctgatgtgaa   6780

aggaccacgg gtgttgtaag ctgggacacg gaagccaaac tggaatcaaa cgccgactgt   6840

aaattgtatc ttataactta ttaaataaaa catttgctcc gtaaagttg               6889


<210>  1598
<211>  1053
<212>  PRT
<213>  Homo sapiens

<400>  1598


Met Val Ala Gly Leu Phe Val Thr His Gln Trp Lys Pro Ile Ala Leu 
1               5                   10                  15      


Gly Asp Gly Cys Gly Pro Ile Ser Asp Ser Ala Lys Gly Gly Val Lys 
            20                  25                  30          


Val Arg Pro Gly Ser Ser Leu Asn Leu Ser Ser Leu Ser Ser Gly Leu 
        35                  40                  45              


Val Glu Pro Val Asn Val Val Asp Asn Gly Asp Gly Thr His Thr Val 
    50                  55                  60                  


Thr Tyr Thr Pro Ser Gln Glu Gly Pro Tyr Met Val Ser Val Lys Tyr 
65                  70                  75                  80  


Ala Asp Glu Glu Ile Pro Arg Ser Pro Phe Lys Val Lys Val Leu Pro 
                85                  90                  95      


Thr Tyr Asp Ala Ser Lys Val Thr Ala Ser Gly Pro Gly Leu Ser Ser 
            100                 105                 110         


Tyr Gly Val Pro Ala Ser Leu Pro Val Asp Phe Ala Ile Asp Ala Arg 
        115                 120                 125             


Asp Ala Gly Glu Gly Leu Leu Ala Val Gln Ile Thr Asp Gln Glu Gly 
    130                 135                 140                 


Lys Pro Lys Arg Ala Ile Val His Asp Asn Lys Asp Gly Thr Tyr Ala 
145                 150                 155                 160 


Val Thr Tyr Ile Pro Asp Lys Thr Gly Arg Tyr Met Ile Gly Val Thr 
                165                 170                 175     


Tyr Gly Gly Asp Asp Ile Pro Leu Ser Pro Tyr Arg Ile Arg Ala Thr 
            180                 185                 190         


Gln Thr Gly Asp Ala Ser Lys Cys Leu Ala Thr Gly Pro Gly Ile Ala 
        195                 200                 205             


Ser Thr Val Lys Thr Gly Glu Glu Val Gly Phe Val Val Asp Ala Lys 
    210                 215                 220                 


Thr Ala Gly Lys Gly Lys Val Thr Cys Thr Val Leu Thr Pro Asp Gly 
225                 230                 235                 240 


Thr Glu Ala Glu Ala Asp Val Ile Glu Asn Glu Asp Gly Thr Tyr Asp 
                245                 250                 255     


Ile Phe Tyr Thr Ala Ala Lys Pro Gly Thr Tyr Val Ile Tyr Val Arg 
            260                 265                 270         


Phe Gly Gly Val Asp Ile Pro Asn Ser Pro Phe Thr Val Met Val Thr 
        275                 280                 285             


Glu Glu Ala Tyr Val Pro Val Ser Asp Met Asn Gly Leu Gly Phe Lys 
    290                 295                 300                 


Pro Phe Asp Leu Val Ile Pro Phe Ala Val Arg Lys Gly Glu Ile Thr 
305                 310                 315                 320 


Gly Glu Val His Met Pro Ser Gly Lys Thr Ala Thr Pro Glu Ile Val 
                325                 330                 335     


Asp Asn Lys Asp Gly Thr Val Thr Val Arg Tyr Ala Pro Thr Glu Val 
            340                 345                 350         


Gly Leu His Glu Met His Ile Lys Tyr Met Gly Ser His Ile Pro Glu 
        355                 360                 365             


Ser Pro Leu Gln Phe Tyr Val Asn Tyr Pro Asn Ser Gly Ser Val Ser 
    370                 375                 380                 


Ala Tyr Gly Pro Gly Leu Val Tyr Gly Val Ala Asn Lys Thr Ala Thr 
385                 390                 395                 400 


Phe Thr Ile Val Thr Glu Asp Ala Gly Glu Gly Gly Leu Asp Leu Ala 
                405                 410                 415     


Ile Glu Gly Pro Ser Lys Ala Glu Ile Ser Cys Ile Asp Asn Lys Asp 
            420                 425                 430         


Gly Thr Cys Thr Val Thr Tyr Leu Pro Thr Leu Pro Gly Asp Tyr Ser 
        435                 440                 445             


Ile Leu Val Lys Tyr Asn Asp Lys His Ile Pro Gly Ser Pro Phe Thr 
    450                 455                 460                 


Ala Lys Ile Thr Asp Asp Ser Arg Arg Cys Ser Gln Val Lys Leu Gly 
465                 470                 475                 480 


Ser Ala Ala Asp Phe Leu Leu Asp Ile Ser Glu Thr Asp Leu Ser Ser 
                485                 490                 495     


Leu Thr Ala Ser Ile Lys Ala Pro Ser Gly Arg Asp Glu Pro Cys Leu 
            500                 505                 510         


Leu Lys Arg Leu Pro Asn Asn His Ile Gly Ile Ser Phe Ile Pro Arg 
        515                 520                 525             


Glu Val Gly Glu His Leu Val Ser Ile Lys Lys Asn Gly Asn His Val 
    530                 535                 540                 


Ala Asn Ser Pro Val Ser Ile Met Val Val Gln Ser Glu Ile Gly Asp 
545                 550                 555                 560 


Ala Arg Arg Ala Lys Val Tyr Gly Arg Gly Leu Ser Glu Gly Arg Thr 
                565                 570                 575     


Phe Glu Met Ser Asp Phe Ile Val Asp Thr Arg Asp Ala Gly Tyr Gly 
            580                 585                 590         


Gly Ile Ser Leu Ala Val Glu Gly Pro Ser Lys Val Asp Ile Gln Thr 
        595                 600                 605             


Glu Asp Leu Glu Asp Gly Thr Cys Lys Val Ser Tyr Phe Pro Thr Val 
    610                 615                 620                 


Pro Gly Val Tyr Ile Val Ser Thr Lys Phe Ala Asp Glu His Val Pro 
625                 630                 635                 640 


Gly Ser Pro Phe Thr Val Lys Ile Ser Gly Glu Gly Arg Val Lys Glu 
                645                 650                 655     


Ser Ile Thr Arg Thr Ser Arg Ala Pro Ser Val Ala Thr Val Gly Ser 
            660                 665                 670         


Ile Cys Asp Leu Asn Leu Lys Ile Pro Glu Ile Asn Ser Ser Asp Met 
        675                 680                 685             


Ser Ala His Val Thr Ser Pro Ser Gly Arg Val Thr Glu Ala Glu Ile 
    690                 695                 700                 


Val Pro Met Gly Lys Asn Ser His Cys Val Arg Phe Val Pro Gln Glu 
705                 710                 715                 720 


Met Gly Val His Thr Val Ser Val Lys Tyr Arg Gly Gln His Val Thr 
                725                 730                 735     


Gly Ser Pro Phe Gln Phe Thr Val Gly Pro Leu Gly Glu Gly Gly Ala 
            740                 745                 750         


His Lys Val Arg Ala Gly Gly Pro Gly Leu Glu Arg Gly Glu Ala Gly 
        755                 760                 765             


Val Pro Ala Glu Phe Ser Ile Trp Thr Arg Glu Ala Gly Ala Gly Gly 
    770                 775                 780                 


Leu Ser Ile Ala Val Glu Gly Pro Ser Lys Ala Glu Ile Thr Phe Asp 
785                 790                 795                 800 


Asp His Lys Asn Gly Ser Cys Gly Val Ser Tyr Ile Ala Gln Glu Pro 
                805                 810                 815     


Gly Asn Tyr Glu Val Ser Ile Lys Phe Asn Asp Glu His Ile Pro Glu 
            820                 825                 830         


Ser Pro Tyr Leu Val Pro Val Ile Ala Pro Ser Asp Asp Ala Arg Arg 
        835                 840                 845             


Leu Thr Val Met Ser Leu Gln Glu Ser Gly Leu Lys Val Asn Gln Pro 
    850                 855                 860                 


Ala Ser Phe Ala Ile Arg Leu Asn Gly Ala Lys Gly Lys Ile Asp Ala 
865                 870                 875                 880 


Lys Val His Ser Pro Ser Gly Ala Val Glu Glu Cys His Val Ser Glu 
                885                 890                 895     


Leu Glu Pro Asp Lys Tyr Ala Val Arg Phe Ile Pro His Glu Asn Gly 
            900                 905                 910         


Val His Thr Ile Asp Val Lys Phe Asn Gly Ser His Val Val Gly Ser 
        915                 920                 925             


Pro Phe Lys Val Arg Val Gly Glu Pro Gly Gln Ala Gly Asn Pro Ala 
    930                 935                 940                 


Leu Val Ser Ala Tyr Gly Thr Gly Leu Glu Gly Gly Thr Thr Gly Ile 
945                 950                 955                 960 


Gln Ser Glu Phe Phe Ile Asn Thr Thr Arg Ala Gly Pro Gly Thr Leu 
                965                 970                 975     


Ser Val Thr Ile Glu Gly Pro Ser Lys Val Lys Met Asp Cys Gln Glu 
            980                 985                 990         


Thr Pro Glu Gly Tyr Lys Val Met  Tyr Thr Pro Met Ala  Pro Gly Asn 
        995                 1000                 1005             


Tyr Leu  Ile Ser Val Lys Tyr  Gly Gly Pro Asn His  Ile Val Gly 
    1010                 1015                 1020             


Ser Pro  Phe Lys Ala Lys Val  Thr Gly Asn Glu Gln  Pro Pro Ser 
    1025                 1030                 1035             


Glu Leu  Leu Ser Leu Pro Gly  Glu Leu Val Val Ser  Asp Gln Ser 
    1040                 1045                 1050             

<210>  1599
<211>  873
<212>  DNA
<213>  Homo sapiens

<400>  1599
ctgccagtct acctgtggac tttgcaattg atgcccgaga tgccggggaa ggcctgcttg     60

tgttgtaaaa tgccttcaga aataagtcct agactggact cttgagggac atattggaga    120

atcttaagaa atgcaagctt gttcaggggg ctgagaagat cctgagtaca ctaggtgcaa    180

accagaactc ttggtggaac agaccagcca ctgcagcaga cagaccagga acacaatgag    240

actgacattt caaaaaaaca aaactggcta gcctgagctg ctggttcagc cctcatccca    300

aggtccgtcc catgacataa cactccacac ccgccccagc caacttcatg ggtcactttt    360

tctggaaaat aatgatctgt acagacagga cagaatgaaa ctcctgcggg tctttggcct    420

gaaagttggg aatggttggg ggagagaagg gcagcagctt attggtggtc ttttcaccat    480

tggcagaaac agtgagagct gtgtggtgca gaaatccaga aatgaggtgt agggaatttt    540

gcctgccttc ctgcagacct gagctggctt tggaatgagg ttaaagtgtc agggacgttg    600

cctgagccca aatgtgtagt gtggtctggg caggcagacc tttaggtttt gctgcttagt    660

cctgaggaag tggccactct tgtggcaggt gtagtatctg gggcgagtgt tgggggtaaa    720

agcccaccct acagaaagtg gaacagcccg gagcctgatg tgaaaggacc acgggtgttg    780

taagctggga cacggaagcc aaactggaat caaacgccga ctgtaaattg tatcttataa    840

cttattaaat aaaacatttg ctccgtaaag ttg                                 873


<210>  1600
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  1600


Met Val Gly Gly Glu Lys Gly Ser Ser Leu Leu Val Val Phe Ser Pro 
1               5                   10                  15      


Leu Ala Glu Thr Val Arg Ala Val Trp Cys Arg Asn Pro Glu Met Arg 
            20                  25                  30          


Cys Arg Glu Phe Cys Leu Pro Ser Cys Arg Pro Glu Leu Ala Leu Glu 
        35                  40                  45              

<210>  1601
<211>  528
<212>  DNA
<213>  Homo sapiens

<400>  1601
ttcgtggagc acggatggtg acgcaaagga gaaaaacact cttaaatgaa caatgtcaaa     60

agttgacaag tgtttacatt tacatacttg agacataaaa gagcctccag atctctggca    120

tgctgtttac agataaacag acgtcgatgg aagggaataa tactacaaca gagtatagac    180

tgttcggaag aaagtccctg agctttggag tttggaatgg agtcttcatg cacctctcca    240

ttgctgcaca aaatgaaata attagaaggt gctttgtcgg ctgtgcacaa ggccaggtca    300

ttaagggcct ataaaccttg tggtcaagtg cggctgctga ccacagtatc aaaggacacc    360

agtgaggatg acagcatggt atttggtgtc tgtctagacc aagcatgctt catttgtaaa    420

aaagccaacg atgcttggtt ttgagggttc aatgaggtaa tgtccccaag gtttctaacc    480

cttttcctgg ttgaagaata ttcagaagaa gatctattat gtaataat                 528


<210>  1602
<211>  64
<212>  PRT
<213>  Homo sapiens

<400>  1602


Met Leu Phe Thr Asp Lys Gln Thr Ser Met Glu Gly Asn Asn Thr Thr 
1               5                   10                  15      


Thr Glu Tyr Arg Leu Phe Gly Arg Lys Ser Leu Ser Phe Gly Val Trp 
            20                  25                  30          


Asn Gly Val Phe Met His Leu Ser Ile Ala Ala Gln Asn Glu Ile Ile 
        35                  40                  45              


Arg Arg Cys Phe Val Gly Cys Ala Gln Gly Gln Val Ile Lys Gly Leu 
    50                  55                  60                  

<210>  1603
<211>  2058
<212>  DNA
<213>  Homo sapiens

<400>  1603
tgtggaaatg aagcatctct ttctgttttc tctttgagat ggtttgagtt agattgtgtc     60

tcttccaagc ttgccacacc ccagtgcctc cagtcatctg ctttcttgaa ggatggccac    120

gctggtgaat tctagacaaa ttctaacccg gggagagggc tggagaattt ctggtcctgg    180

ttgggagata ctccctgtta aaccttcgga tatgctgacc tagctgaggt agccaggggc    240

tatttaaaaa ttcaaaatct cagatctggc tgtggataaa cccccaaggt ggtacgtgca    300

gtacttggag gcgtgagggc agaaggtcct ccccagcagt ttgtacggga cacatcatct    360

atgggatatt agtaaatatc cttaaggaaa ggcttctgtg gtcaaaacca ggttcagcag    420

gttatttcac tatggggctt ctcaggacgc ttaacctact catccccctc tgggctttgc    480

aaacgaggcc gccattgctt tctttctgct atgtagaaat agattgaggc gtaagggtcg    540

gatgtccttt ctccattcat caggctccct cttcctgagg agctgctgtc agaacagcct    600

ggggctgctg tgttgcaggt tatggtggca tatccttggc ggtggaaggc cccagcaaag    660

tggacatcca gacggaggac ctggaagatg gcacctgcaa agtctcctac ttccctaccg    720

tgcctggggt ttatatcgtc tccaccaaat tcgctgacga gcacgtgcct gggagcccat    780

ttaccgtgaa gatcagtggg gagggaagag tcaaagagag catcacccgc accagtcggg    840

ccccgtccgt ggccactgtc gggagcattt gtgacctgaa cctgaaaatc ccaggtgggc    900

gtcggggact agtagggtgg ggaagccttg gctccagcct tcagggcagt gggtgccttt    960

gggaaccaag tttaggcatg gcccagaaca cagtatccaa gtcggctgtg ctgacctttt   1020

catttcactt catttcatta tgttcttcta tgtttatttt cacagagtct catccaagaa   1080

aaacaaatgt ttaccttgct acctttttcc tcttccaaat aaaaatagct ttattgtgtc   1140

acatggggga aacgtagata tgcttttaga tttttagatt aactatctgt caaatagaat   1200

catgtcagtg aaagaactgg ccctgccgat gccagggtct ggaagtattt aagaggtggc   1260

agcccagcgg catccttcta gtatttctct ttcattcctg aaattagaac gagggctgtg   1320

ctgcagaact cgctgggcca catctagccc tttggtggtg aattgttctt cttgggcccc   1380

gattagccag tcaacaggtc acacagtctg tctgaaatgt gttccaagtt ctttctataa   1440

agaatccttc cagagggaag ccactgtgag tgaaaatttt gaggctcctc tgcccagaag   1500

ttggcatgtc ctgtggaatt gcacaaattc tacagagaag ggaaatctaa atcgtcttca   1560

gatggagctt gtgttgcgag ctctggagag ggggttgtct ttctacactg catctcccat   1620

ccttcctaac gagtcacgga gctgtcgact ccgccttctt ggctttagtt aacaggttct   1680

tcttgtgtag tcacatcaac gtcgggtcac atgggaatgt ggtaaagcct cattactgta   1740

gagttcagac atgatcactt aaaaagagct ttattgggcc gggcgcggtg gcttactcct   1800

ataatcccag cactttgggg ggccgaggca ggcagatcac ctgaggtcag gagttcgaga   1860

ccagcctggc taacatggca aaaccctatc tcttctaaaa atacaaaaat aagcagggcg   1920

tggtggcggg cacctgtaat cccacctact caggaggctg aggcacaaga attgcgtaaa   1980

cctgggaggt ggaggttgca gtgagctgaa attgcaccgc tgcactccag cctgggcaac   2040

aaagtgagac tccttctc                                                 2058


<210>  1604
<211>  55
<212>  PRT
<213>  Homo sapiens

<400>  1604


Met Val Ala Tyr Pro Trp Arg Trp Lys Ala Pro Ala Lys Trp Thr Ser 
1               5                   10                  15      


Arg Arg Arg Thr Trp Lys Met Ala Pro Ala Lys Ser Pro Thr Ser Leu 
            20                  25                  30          


Pro Cys Leu Gly Phe Ile Ser Ser Pro Pro Asn Ser Leu Thr Ser Thr 
        35                  40                  45              


Cys Leu Gly Ala His Leu Pro 
    50                  55  

<210>  1605
<211>  4316
<212>  DNA
<213>  Homo sapiens

<400>  1605
gccaaataca ttaacacgga cactggaaga gattaagcgg attttaagtc atctcctttg     60

ccaaatgaca accaaactag gtgtcccctt tttctctgcc catcttcccc tagccttgtt    120

tcataaatgc tgaagagtga accagcagct caggctagcc agttttgttt ttttgaaatg    180

tcagtctcat tgtgttcctg gtctgtctgc tgcagtggct ggtctgttcc accaagagtt    240

ctggtttgca cctagtgtac tcaggatctt ctcagccccc tgaacaagct tgcatttctt    300

aagattctcc aatatgtccc tcaagagtcc agtctaggac ttatttctga aggcatttta    360

caacagcaat attttaggga tggggtttca gccccacaaa caggctggag ggctttgtat    420

aaaatgaatt acaaacaagc aacaaaagca accacaagaa ctctctccag gatttgagaa    480

aactgtttta aggcactgtg acatgaaaag ggctgccagg gatgtgttcc tccccccact    540

tcacagccag cacataatcg cccctctcct tgacgacgta tgtgacgttg tattgctggt    600

tgcctacatg cttcatggag acctcctcgc agggggtggt gggcccatgg accccgatca    660

gcagcatgtt ggagcctagg aggcaaaagg tggttactcc acccggatgc atcaggacag    720

gcacaggaag aagaggaaat atgagagcca aaggaaagga agcagaggca cagtgaagtc    780

agataattca tctggagtca cacagctggg gaccagcaga actgggattt aaacataaag    840

tctgtccaac ttggagctaa agcacttacc tgagagaaga tggaaggaaa aaaatccaca    900

agcagaagtc tctcaccact gcctctagct ataacctgta tctgacacca caaaacatct    960

ctgggcgtgg cggtcttccc ccaccccctc aaatatgtcc agctcagttc ctgtgagttt   1020

aatgcatgtt aaacgcagca ctgcttgttc ttcaaggcag ttaaggaagg aggcccttct   1080

ggtatacccc gagcacactg gggttcctgg accatttcat taggaaaatt gctcagcggc   1140

tccaaagaat ctggagctcc ctggtctatc tcccagcctc tcaagccgcc tccagcaggg   1200

tcccgcccca aattctccac attcccctac tccaaaatct acagaatgga ccatttaaag   1260

cttgagccaa gagatacagc aaactcaccc attaaaaaca gagggaggtt tgctttgttc   1320

agaaggtcag gatactgggc gctctggcgg ccaagcacag ataccttttc attccatgca   1380

cactgcagct gtgtaatctc agaatggata tttagggaaa ggcttgggag caggagggct   1440

ggaaaaacaa ggcgccttcc ctgtgacaag agcaatattt acacagggtt tgaagcaggc   1500

ggttctgtac ctctcccctc ctggctagga gcttccctgc aagagcaact ccttctctca   1560

gcagcgtcca gcacttgcag agcacagcct gaaacccaag ctcccaaaaa ggtgtgcgaa   1620

cagccaaaag gaaatgggag agggcccagg cacagcggca tgagccagca ggagggtgag   1680

atgcttcctg gccagtgtgg gagaccccag cagctgctgt gaggcctggc ctgaagcctg   1740

ccacgcgctc caagtgccga gaggacccca cctgggccct caaaggtgag taccttgtca   1800

gggcccaagt gccagcactg ctgcctggaa agtactcctg agtggctggg aggacagggg   1860

tcctggttta ggacatcccc aaagtgggct ggggatgcag tcactgcctc tgggtgagcc   1920

agccacttag agagggggcc aagctcgggg gttcagcgca taggctctga ggtcacggat   1980

gtagactgat tcctggttct gcctcctccc agctgactgc tttttggggg agtgttgttt   2040

ggggagtgac tcaacctctg catctcactt tccacatctg taaaatggac atcacttacg   2100

gtaaaatgat accatgcctt tcacaaaagg caagccgcag gcccagagtt cagcgtggag   2160

ccgggctgga tttgcctggg gagtctggca gcactcacac cacccctgtg ggtggctttg   2220

ctgaggccac tgctttggcc agagtcccgg gcagcctgcc agcccaccag tcactcctgc   2280

acccggagag ggccccttgg ccacacaggt cacttgctcc tagggctgga tgccaggcaa   2340

ccatgcagcc actcacccct cacccctggg aggcaagtct gctccatccc actctcctta   2400

tgcggggtgg gggtacacac acaagagact caagaaacca ggacatactg ctttcccaag   2460

agggtccaaa gtaacaccaa atgcaaacat gccccagtga gtccacactg cgcacttccc   2520

ctgcaaagac taaggactga ctctccaccc tggcagcctc cataacagtg acgcactcac   2580

tgcgcaccac ccgatgccac ctgttcaaat aactgcgatt cacagcagga attctcacta   2640

cagccaggaa aaggagggga agatctgttc tgacatggaa agatctttaa gatgtcaaag   2700

caaaaacaca agctatacca cacagtggat acagtaagat tctttctgta agacaaaagc   2760

aaaactctgt gtctgcttgt ctaatgaacc aattagctaa ccaacccagc aaccaagaat   2820

gaagacagac aatgagatga cagacagggt gaaggtcctc ccttcccaga gccgtttgct   2880

tccagaccca ggtgggggag gaggagagaa gatggagtga gtctcacttt atttacttct   2940

tcactgcctg tatctttcat aatcaaacat gtcccatctg tggcaaagaa taaaagtaaa   3000

ttgtaacggg tctaaaaagc ttcagaattc tttgaacatt tcagtctttt ctcctcctcc   3060

attaagatct gagagtaaaa agaggaggag ataggctggg acaggtctta ttgctgcttc   3120

agtgcatttc tgggagcctg gtaccatgaa agaacagacg ggtaggagcc cacttggacg   3180

catcatgaat tctgtgcagg caaagaaacc ctcaaaatta atgacactgt gctgtgttcc   3240

ctgactatca gcatcctgtt ctgaaagtca agaaacttgg cagaggaagg aatctgaatc   3300

acaactaaca gtaatgaggt gtgataacac ggccatcgag ctctcactct ggatttatcg   3360

tgggtcaaac cgcaactccc aaaacagctt tggacagcaa gcgcctccga agtgtgcatg   3420

accccagttt ccacggggag tacgtgtaaa aagctttcat ggggcttgag gatttccatc   3480

tggcttggtc cctggagctg gttcagttaa ggcttcaaga agcagaagag tgggttacct   3540

gtggtgcccc cttcgagtcc cgtgccatag gcggacacca gggcagggtt ccccgcttgt   3600

ccaggctccc caacgcgcac tttgaagggg cttccaacca cgtggctccc attgaacttg   3660

acatcgatgg tgtggacacc attctcatga gggatgaagc gaacagcata cttatctagg   3720

agaatgagca aaggcacagg gtgaaatcaa gcaaatggac acccctgagt tcagtgagga   3780

taaaggatgg aggccaagct gagatggccc atttaaaatc aacagttcta cagggagcct   3840

ggcactcagc atcctggatt tcagaaccag acagaccccc tgggtatccc tcatcagccc   3900

caagggaaac gcatccacat tgcaaatcct ataaacacag gacaagactc tgacccctgc   3960

ctcagaagaa cacttccttt ctttagaaaa cctcacttct tcagtgtgaa attctgtgaa   4020

tgctgttact aatcctgtca cgagatgaat ctcatttcac caaaattaaa ttatgttttt   4080

ccactaaaat gatgatacaa gttgaagaca cagcactctg aaattggaag acctcaccac   4140

ttaaggctcc gcagcggctt actcagctga actccaggtt actactcttt actttgttca   4200

cccattgggg agttcagttt gtttttaaac attgggagat ggccattcta actactgttc   4260

aatgtctctg ttttgggaag gcataacaag aaataaaaag gaatatatat gaaggg       4316


<210>  1606
<211>  53
<212>  PRT
<213>  Homo sapiens

<400>  1606


Met Glu Thr Ser Ser Gln Gly Val Val Gly Pro Trp Thr Pro Ile Ser 
1               5                   10                  15      


Ser Met Leu Glu Pro Arg Arg Gln Lys Val Val Thr Pro Pro Gly Cys 
            20                  25                  30          


Ile Arg Thr Gly Thr Gly Arg Arg Gly Asn Met Arg Ala Lys Gly Lys 
        35                  40                  45              


Glu Ala Glu Ala Gln 
    50              

<210>  1607
<211>  952
<212>  DNA
<213>  Homo sapiens

<400>  1607
ctctcagcag cgtccagcac ttgcagagca cagcctgaaa cccaagctcc caaaaaggtg     60

tgcgaacagc caaaaggaaa tgggagaggg cccaggcaca gcggcatgag ccagcaggag    120

ggtgagatgc ttcctggcca gtgtgggaga ccccagcagc tgctgtgagg cctggcctga    180

agcctgccac gcgctccaag tgccgagagg accccacctg ggccctcaaa gcctccataa    240

cagtgacgca ctcactgcgc accacccgat gccacctgtt caaataactg cgattcacag    300

caggaattct cactacagcc aggaaaagga ggggaagatc tgttctgaca tggaaagatc    360

tttaagatgt caaagcaaaa acacaagcta taccacacag tggatacagt aagattcttt    420

ctgtaagaca aaagcaaaac tctgtgtctg cttgtctaat gaaccaatta gctaaccaac    480

ccagcaacca agaatgaaga cagacaatga gatgacagac agggtgaagg tcctcccttc    540

ccagagccgt ttgcttccag acccaggtgg gggaggagga gagaagatgg agtgagtctc    600

actttattta cttcttcact gcctgtatct ttcataatca aacatgtccc atctgtggca    660

aagaataaaa gtaaattgta acgggtctaa aaagcttcag aattctttga acatttcagt    720

cttttctcct cctccattaa gatctgagag taaaaagagg aggagatagg ctgggacagg    780

tcttattgct gcttcagtgc atttctggga gcctggtacc atgaaagaac agacgggtag    840

gagcccactt ggacgcatca tgaattctgt gcaggcaaag aaaccctcaa aattaatgac    900

actgtgctgt gttccctgac tatcagcatc ctgttctgaa agtcaagaaa ct            952


<210>  1608
<211>  47
<212>  PRT
<213>  Homo sapiens

<400>  1608


Met Pro Pro Val Gln Ile Thr Ala Ile His Ser Arg Asn Ser His Tyr 
1               5                   10                  15      


Ser Gln Glu Lys Glu Gly Lys Ile Cys Ser Asp Met Glu Arg Ser Leu 
            20                  25                  30          


Arg Cys Gln Ser Lys Asn Thr Ser Tyr Thr Thr Gln Trp Ile Gln 
        35                  40                  45          

<210>  1609
<211>  2485
<212>  DNA
<213>  Homo sapiens

<400>  1609
cacgcctccc ccacacccct ggagggagag ctggactctg gtggctgaag cagcacttca     60

ggctcacagt gtgactcagg cttcttgccc tcagccacaa tggctcatgc ccagaggaga    120

gaacagggtg tccaggctgt tggtgcttgt gggcgaaatg tcagccatgc tcctcctgcc    180

ttggcctaga aaagggagcc cccaccccgc agggcctgag gttctctctg ccagaagttc    240

agagctagtg ccagtgggtt cccatgccac cagggtgagc cctctgtaag gggatctatg    300

tgtgtccctc accacggcct cagtgctccc aggaaagccc tccaagtcat caacacagca    360

ttttctattc ctttctccca ggtatccagt cggaattctt tattaacacc acccgagcag    420

gtccagggac attatccgtc accatcgaag gcccatccaa ggttaaaatg gattgccagg    480

aaacacctga agggtacaaa gtcatgtaca cccccatggc tcctggtaac tacctgatca    540

gcgtcaaata cggtgggccc aaccacatcg tgggcagtcc cttcaaggcc aaggtgacag    600

gccagcgtct agttagccct ggctcagcca acgagacctc atccatcctg gtggagtcag    660

tgaccaggtc gtctacagag acctgctata gcgccattcc caaggcatcc tcggacgcca    720

gcaaggtgac ctctaagggg gcagggctct caaaggcctt tgtgggccag aagagttcct    780

tcctggtgga ctgcagcaaa gctggctcca acatgctgct gatcggggtc catgggccca    840

ccaccccctg cgaggaggtc tccatgaagc atgtaggcaa ccagcaatac aacgtcacat    900

acgtcgtcaa ggagaggggc gattatgtgc tggctgtgaa gtggggggag gaacacatcc    960

ctggcagccc ttttcatgtc acagtgcctt aaaacagttt tctcaaatcc tggagagagt   1020

tcttgtggtt gcttttgttg cttgtttgta attcatttta tacaaagccc tccagcctgt   1080

ttgtggggct gaaaccccat ccctaaaata ttgctgttgt aaaatgcctt cagaaataag   1140

tcctagactg gactcttgag ggacatattg gagaatctta agaaatgcaa gcttgttcag   1200

ggggctgaga agatcctgag tacactaggt gcaaaccaga actcttggtg gaacagacca   1260

gccactgcag cagacagacc aggaacacaa tgagactgac atttcaaaaa aacaaaactg   1320

gctagcctga gctgctggtt cactcttcag catttatgaa acaaggctag gggaagatgg   1380

gcagagaaaa aggggacacc tagtttggtt gtcatttggc aaaggagatg acttaaaatc   1440

cgcttaatct cttccagtgt ccgtgttaat gtatttggct attagatcac tagcactgct   1500

ttaccgctcc tcatcgccaa cacccccatg ctctgtggcc ttcttacact tctcagaggg   1560

cagagtggca gccgggcacc ctacagaaac tcagagggca gagtggcagc caggcccaca   1620

tgtctctcaa gtacctgtcc cctcgctctg gtgattattt cttgcagaat caccacacga   1680

gaccatcccg gcagtcatgg ttttgcttta gttttccaag tccgtttcag tcccttcctt   1740

ggtctgaaga aattctgcag tggcgagcag tttcccactt gccaaagatc ccttttaacc   1800

aacactagcc cttgttttta acacacgctc cagcccttca tcagcctggg cagtcttacc   1860

aaaatgttta aagtgatctc agaggggccc atggattaac gccctcatcc caaggtccgt   1920

cccatgacat aacactccac acccgcccca gccaacttca tgggtcactt tttctggaaa   1980

ataatgatct gtacagacag gacagaatga aactcctgcg ggtctttggc ctgaaagttg   2040

ggaatggttg ggggagagaa gggcagcagc ttattggtgg tcttttcacc attggcagaa   2100

acagtgagag ctgtgtggtg cagaaatcca gaaatgaggt gtagggaatt ttgcctgcct   2160

tcctgcagac ctgagctggc tttggaatga ggttaaagtg tcagggacgt tgcctgagcc   2220

caaatgtgta gtgtggtctg ggcaggcaga cctttaggtt ttgctgctta gtcctgagga   2280

agtggccact cttgtggcag gtgtagtatc tggggcgagt gttgggggta aaagcccacc   2340

ctacagaaag tggaacagcc cggagcctga tgtgaaagga ccacgggtgt tgtaagctgg   2400

gacacggaag ccaaactgga atcaaacgcc gactgtaaat tgtatcttat aacttattaa   2460

ataaaacatt tgctccgtaa agttg                                         2485


<210>  1610
<211>  174
<212>  PRT
<213>  Homo sapiens

<400>  1610


Met Asp Cys Gln Glu Thr Pro Glu Gly Tyr Lys Val Met Tyr Thr Pro 
1               5                   10                  15      


Met Ala Pro Gly Asn Tyr Leu Ile Ser Val Lys Tyr Gly Gly Pro Asn 
            20                  25                  30          


His Ile Val Gly Ser Pro Phe Lys Ala Lys Val Thr Gly Gln Arg Leu 
        35                  40                  45              


Val Ser Pro Gly Ser Ala Asn Glu Thr Ser Ser Ile Leu Val Glu Ser 
    50                  55                  60                  


Val Thr Arg Ser Ser Thr Glu Thr Cys Tyr Ser Ala Ile Pro Lys Ala 
65                  70                  75                  80  


Ser Ser Asp Ala Ser Lys Val Thr Ser Lys Gly Ala Gly Leu Ser Lys 
                85                  90                  95      


Ala Phe Val Gly Gln Lys Ser Ser Phe Leu Val Asp Cys Ser Lys Ala 
            100                 105                 110         


Gly Ser Asn Met Leu Leu Ile Gly Val His Gly Pro Thr Thr Pro Cys 
        115                 120                 125             


Glu Glu Val Ser Met Lys His Val Gly Asn Gln Gln Tyr Asn Val Thr 
    130                 135                 140                 


Tyr Val Val Lys Glu Arg Gly Asp Tyr Val Leu Ala Val Lys Trp Gly 
145                 150                 155                 160 


Glu Glu His Ile Pro Gly Ser Pro Phe His Val Thr Val Pro 
                165                 170                 

<210>  1611
<211>  415
<212>  DNA
<213>  Homo sapiens

<400>  1611
aggccagcgt ctagttagcc ctggctcagc caacgagacc tcatccatcc tggtggagtc     60

agtgaccagg tcgtctacag agacctgcta tagcgccatt cccaaggcat cctcggacgc    120

cagcaaggtg acctctaagg gggcagggct ctcaaaggcc tttgtgggcc agaagagttc    180

cttcctggtg gactgcagca aagctggctc caacatgctg ctgatcgggg tccatgggcc    240

caccaccccc tgcgaggagg tctccatgaa gcatgtaggc aaccagcaat acaacgtcac    300

atacgtcgtc aaggagaggg gcgattatgt gctggctgtg aagtgggggg aggaacacat    360

ccctggcagc ccttttcatg tcacagtgcc ttaaaacagt tttctcaaat cctgg         415


<210>  1612
<211>  59
<212>  PRT
<213>  Homo sapiens

<400>  1612


Met Leu Leu Ile Gly Val His Gly Pro Thr Thr Pro Cys Glu Glu Val 
1               5                   10                  15      


Ser Met Lys His Val Gly Asn Gln Gln Tyr Asn Val Thr Tyr Val Val 
            20                  25                  30          


Lys Glu Arg Gly Asp Tyr Val Leu Ala Val Lys Trp Gly Glu Glu His 
        35                  40                  45              


Ile Pro Gly Ser Pro Phe His Val Thr Val Pro 
    50                  55                  

<210>  1613
<211>  1344
<212>  DNA
<213>  Homo sapiens

<400>  1613
atgaagcatg taggcaacca gcaatacaac gtcacatacg tcgtcaagga gaggggcgat     60

tatgtgctgg ctgtgaagtg gggggaggaa cacatccctg gcagcccttt tcatgtcaca    120

gtgccttaaa acagttttct caaatcctgg agagagttct tgtggttgct tttgttgctt    180

gtttgtaatt cattttatac aaagccctcc agcctgtttg tggggctgaa accccatccc    240

taaaatattg ctgttgtaaa atgccttcag aaataagtcc tagactggac tcttgaggga    300

catattggag aatcttaaga aatgcaagct tgttcagggg gctgagaaga tcctgagtac    360

actaggtgca aaccagaact cttggtggaa cagaccagcc actgcagcag acagaccagg    420

aacacaatga gactgacatt tcaaaaaaac aaaactggct agcctgagct gctggttcac    480

tcttcagcat ttatgaaaca aggctagggg aagatgggca gagaaaaagg ggacacctag    540

tttggttgtc atttggcaaa ggagatgact taaaatccgc ttaatctctt ccagtgtccg    600

tgttaatgta tttggctatt agatcactag cactgcttta ccgctcctca tcgccaacac    660

ccccatgctc tgtggccttc ttacacttct cagagggcag agtggcagcc gggcacccta    720

cagaaactca gagggcagag tggcagccag gcccacatgt ctctcaagta cctgtcccct    780

cgctctggtg attatttctt gcagaatcac cacacgagac catcccggca gtcatggttt    840

tgctttagtt ttccaagtcc gtttcagtcc cttccttggt ctgaagaaat tctgcagtgg    900

cgagcagttt cccacttgcc aaagatccct tttaaccaac actagccctt gtttttaaca    960

cacgctccag cccttcatca gcctgggcag tcttaccaaa atgtttaaag tgatctcaga   1020

ggggcccatg gattaacgcc ctcatcccaa ggtccgtccc atgacataac actccacacc   1080

cgccccagcc aacttcatgg gtcacttttt ctggaaaata atgatctgta cagacaggac   1140

agaagtggcc actcttgtgg caggtgtagt atctggggcg agtgttgggg gtaaaagccc   1200

accctacaga aagtggaaca gcccggagcc tgatgtgaaa ggaccacggg tgttgtaagc   1260

tgggacacgg aagccaaact ggaatcaaac gccgactgta aattgtatct tataacttat   1320

taaataaaac atttgctccg taaa                                          1344


<210>  1614
<211>  53
<212>  PRT
<213>  Homo sapiens

<400>  1614


Met Gly His Phe Phe Trp Lys Ile Met Ile Cys Thr Asp Arg Thr Glu 
1               5                   10                  15      


Val Ala Thr Leu Val Ala Gly Val Val Ser Gly Ala Ser Val Gly Gly 
            20                  25                  30          


Lys Ser Pro Pro Tyr Arg Lys Trp Asn Ser Pro Glu Pro Asp Val Lys 
        35                  40                  45              


Gly Pro Arg Val Leu 
    50              

<210>  1615
<211>  778
<212>  DNA
<213>  Homo sapiens

<400>  1615
cttgtggttg cttttgttgc ttgtttgtaa ttcattttat acaaagccct ccagcctgtt     60

tgtggggctg aaaccccatc cctaaaatat tgctgttgta aaatgccttc agaaataagt    120

cctagactgg actcttgagg gacatattgg agaatcttaa gaaatgcaag cttgttcagg    180

gggctgagaa gatcctgagt acactaggtg caaaccagaa ctcttggtgg aacagaccag    240

ccactgcagc agacagacca ggaacacaat gagactgaca tttcaaaaaa acaaaactgg    300

ctagcctgag ctgctggttc actcttcagc atttatgaaa caaggctagg ggaagatggg    360

cagagaaaaa ggggacacct agtttggttg tcatttggca aaggagatga cttaaaaaat    420

ccagaaatga ggtgtaggga attttgcctg ccttcctgca gacctgagct ggctttggaa    480

tgaggttaaa gtgtcaggga cgttgcctga gcccaaatgt gtagtgtggt ctgggcaggc    540

agacctttag gttttgctgc ttagtcctga ggaagtggcc actcttgtgg caggtgtagt    600

atctggggcg agtgttgggg gtaaaagccc accctacaga aagtggaaca gcccggagcc    660

tgatgtgaaa ggaccacggg tgttgtaagc tgggacacgg aagccaaact ggaatcaaac    720

gccgactgta aattgtatct tataacttat taaataaaac atttgctccg taaagttg      778


<210>  1616
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  1616


Thr Gly Leu Leu Arg Asp Ile Leu Glu Asn Leu Lys Lys Cys Lys Leu 
1               5                   10                  15      


Val Gln Gly Ala Glu Lys Ile Leu Ser Thr Leu Gly Ala Asn Gln Asn 
            20                  25                  30          


Ser Trp Trp Asn Arg Pro Ala Thr Ala Ala Asp Arg Pro Gly Thr Gln 
        35                  40                  45              

<210>  1617
<211>  632
<212>  DNA
<213>  Homo sapiens

<400>  1617
atgagagacc tggaggagac ttcatgattt tattcatccc ccaagatttc ctcaggactg     60

gtaccatttt ccatcactgt cttctgccgt cagcaacatg tgagctttct ccacagtctg    120

atccgtgtct ctctctcact gcgggctgcc accccaccaa atctttggca tggctaaggc    180

aagaaccttt ggcgttacat tttggcaagc ctgccaggag gatctccagg aaaggcatct    240

ggaccatcac gtggttcgag accatcaagc tacaagaggt cttacaaatg gaatctcaaa    300

tgagctcaac tcacggcttc taccgaggac ccctggatcg acccgctggt ccctcactag    360

gctaaaaagt tcccctctgg aggacaccac aactgcaggg ccccttcttc gcccctaatc    420

agcagaaagt agccagaacg acagccgccc aggtcccaac aggagttggg gtgtccaatc    480

tagaggggga actgagagga ggttccagct gggcttcctg ggttgagtag gggctcagaa    540

agttgtgaaa ctcactcatt tcttacatca ggacttactt tggtcctgga tgaataatat    600

tgaatatata tgcttaaaat attcctaaca cc                                  632


<210>  1618
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  1618


Met Ile Leu Phe Ile Pro Gln Asp Phe Leu Arg Thr Gly Thr Ile Phe 
1               5                   10                  15      


His His Cys Leu Leu Pro Ser Ala Thr Cys Glu Leu Ser Pro Gln Ser 
            20                  25                  30          


Asp Pro Cys Leu Ser Leu Thr Ala Gly Cys His Pro Thr Lys Ser Leu 
        35                  40                  45              


Ala Trp Leu Arg Gln Glu Pro Leu Ala Leu His Phe Gly Lys Pro Ala 
    50                  55                  60                  


Arg Arg Ile Ser Arg Lys Gly Ile Trp Thr Ile Thr Trp Phe Glu Thr 
65                  70                  75                  80  


Ile Lys Leu Gln Glu Val Leu Gln Met Glu Ser Gln Met Ser Ser Thr 
                85                  90                  95      


His Gly Phe Tyr Arg Gly Pro Leu Asp Arg Pro Ala Gly Pro Ser Leu 
            100                 105                 110         


Gly 
    

<210>  1619
<211>  614
<212>  DNA
<213>  Homo sapiens

<400>  1619
tgcagtggaa caatcatggc ttactgtagc cttgaccttg agggcttaag caatcctgcc     60

acctcagcct gcctagtact gggactacag gtacgcgcca ccacgcccag aaattgccac    120

agtcacctca accttcagca accaccaact tgatcaatca gcagccaata acgtgaagtc    180

atgaccattc accagcaaaa agtttatgat tcaccaaaat attagatgat cattaacatt    240

tttagcaata atgtatttgt cattaaggtg ttagtgcatt ggaaaatcat ttaaagaatg    300

tatcagctaa ttgaaggctt atgtgtaaac aagattcctg ccaggctttg actactaccc    360

ttggccttcc tatacagggt tgtaaagaat catcatgatg tatgtttgaa attatgttta    420

acagtattac agtcaatata gactaaattt tgatgcagta acaacctcag aacttttaca    480

atcattgctg gactgagaga gaaagagaga gtgaacaggg aatgtcacat gagcagagaa    540

tgtcactatc tcaactgtaa aaaacaaaca ttacttctac tcacatttca ttgcccagaa    600

ctagtcctat acct                                                      614


<210>  1620
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  1620


Met Ala Tyr Cys Ser Leu Asp Leu Glu Gly Leu Ser Asn Pro Ala Thr 
1               5                   10                  15      


Ser Ala Cys Leu Val Leu Gly Leu Gln Val Arg Ala Thr Thr Pro Arg 
            20                  25                  30          


Asn Cys His Ser His Leu Asn Leu Gln Gln Pro Pro Thr 
        35                  40                  45  

<210>  1621
<211>  403
<212>  DNA
<213>  Homo sapiens

<400>  1621
ccatggtccc catgacttgc ctgtttgcct gctctggcta agggtcttga ccagtggggc     60

actgaagaag cgagccacac ctccatcgta cgccctgcga ggaggggtct cactcagtga    120

cccaggctga atgcagtgga acaatcatgg cttactgtag ccttgacctt gagggcttaa    180

gcaatcctgc cacctcagcc tgcctagtac tgggactaca gaaacatcaa atatattcag    240

ctcccgtctc tcttcaacca tgtaaaatta tttcaacaac tatcagctat tgaaggtgaa    300

actggcatgt ctgtttgttc ttctcttcct ggtgtcaaag actcttaaag catgcatata    360

aaatatgaaa gtaaataaaa cgtaatcaaa aatactaaca ttc                      403


<210>  1622
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  1622


Met Ala Tyr Cys Ser Leu Asp Leu Glu Gly Leu Ser Asn Pro Ala Thr 
1               5                   10                  15      


Ser Ala Cys Leu Val Leu Gly Leu Gln Lys His Gln Ile Tyr Ser Ala 
            20                  25                  30          


Pro Val Ser Leu Gln Pro Cys Lys Ile Ile Ser Thr Thr Ile Ser Tyr 
        35                  40                  45              

<210>  1623
<211>  461
<212>  DNA
<213>  Homo sapiens

<400>  1623
cattgaccca atgaagaata ttgtatttct tgtccacaaa actctggaat gcacaggtgg     60

aggctaagga gatttataat ctgccatctg caacctggag actaaggaga gccagtggaa    120

ttgtgccagt tgaagttcaa aagcatgaga accagaagaa ctgatgatgt gaacagatgg    180

gtctcactca gtgacccagg ctgaatgcag tggaacaatc atggcttact gtagccttga    240

ccttgagggc ttaagcaatc ctgccacctc agcctgccta gtactgggac tacagaaaca    300

tcaaatatat tcagctcccg tctctcttca accatgtaaa attatttcaa caactatcag    360

ctattgaagg tgaaactggc atgtctgttt gttcttctct tcctggtgtc aaagactctt    420

aaagcatgca tataaaatat gaaagtaaat aaaacgtaat c                        461


<210>  1624
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  1624


Met Ala Tyr Cys Ser Leu Asp Leu Glu Gly Leu Ser Asn Pro Ala Thr 
1               5                   10                  15      


Ser Ala Cys Leu Val Leu Gly Leu Gln Lys His Gln Ile Tyr Ser Ala 
            20                  25                  30          


Pro Val Ser Leu Gln Pro Cys Lys Ile Ile Ser Thr Thr Ile Ser Tyr 
        35                  40                  45              

<210>  1625
<211>  745
<212>  DNA
<213>  Homo sapiens

<400>  1625
cacccagaac tggccgctca gttttcaggt tttaaactgc cgttgacttg aaggttgagt     60

ttcactgggg acctacctct atctgcctag taatctgtgt ctcctgtagc tatcatcatc    120

actgattttc tacgtacaga tttcaattcc aaacaaaaat atatgagaac gttcatttct    180

ccatacaact gcatcatgga tggagatgga gcccattatt tgaagcaaac taacacagga    240

acagcaaagc aaataccata tattctcact tataaatggc agctgaacaa cgaggacaca    300

tggacacaaa cagcagaaca acagacacca ggagctactt gaagggaccg gcgtgagagt    360

atggaggctg aagccataga aaggagaaat tattccagct gaggccaaaa catgaaccaa    420

ggctgggtca ttggccttat cccgcaccga agttgaaact tacaccatct gttcacatca    480

tcagttcttc tggttctcat gcttttgaac ttcaactggc acaattccac tggctctcct    540

tagtctccag gttgcagatg gcagattata aatctcctta gcctccacct ttataatcct    600

aactattact gacacctctt tgaggacaaa ggaagtagct ttctgcaagc caaaaagacc    660

tcagaaaaac aacaaatctt ccaaactctt gattttgact ttttgcctcc agaattgtga    720

agaaataaat atctgttatt taagt                                          745


<210>  1626
<211>  59
<212>  PRT
<213>  Homo sapiens

<400>  1626


Met Arg Thr Phe Ile Ser Pro Tyr Asn Cys Ile Met Asp Gly Asp Gly 
1               5                   10                  15      


Ala His Tyr Leu Lys Gln Thr Asn Thr Gly Thr Ala Lys Gln Ile Pro 
            20                  25                  30          


Tyr Ile Leu Thr Tyr Lys Trp Gln Leu Asn Asn Glu Asp Thr Trp Thr 
        35                  40                  45              


Gln Thr Ala Glu Gln Gln Thr Pro Gly Ala Thr 
    50                  55                  

<210>  1627
<211>  453
<212>  DNA
<213>  Homo sapiens

<400>  1627
gtttcactgg ggacctacct ctatctgcct agtaatctgt gtctcctgta gctatcatca     60

tcactgattt tctacgtaca gatttcaatt ccaaacaaaa atatatgaga acgttcattt    120

ctccatacaa ctggctgggt cattggcctt atcccgcacc gaagttgaaa cttacaccat    180

ctgttcacat catcagttct tctggttctc atgcttttga acttcaactg gcacaattcc    240

actggctctc cttagtctcc aggttgcaga tggcagatta taaatctcct tagcctccac    300

ctttataatc ctaactatta ctgacacctc tttgaggaca aaggaagtag ctttctgcaa    360

gccaaaaaga cctcagaaaa acaacaaatc ttccaaactc ttgattttga ctttttgcct    420

ccagaattgt gaagaaataa atatctgtta ttt                                 453


<210>  1628
<211>  62
<212>  PRT
<213>  Homo sapiens

<400>  1628


Met Arg Thr Phe Ile Ser Pro Tyr Asn Trp Leu Gly His Trp Pro Tyr 
1               5                   10                  15      


Pro Ala Pro Lys Leu Lys Leu Thr Pro Ser Val His Ile Ile Ser Ser 
            20                  25                  30          


Ser Gly Ser His Ala Phe Glu Leu Gln Leu Ala Gln Phe His Trp Leu 
        35                  40                  45              


Ser Leu Val Ser Arg Leu Gln Met Ala Asp Tyr Lys Ser Pro 
    50                  55                  60          

<210>  1629
<211>  271
<212>  DNA
<213>  Homo sapiens

<400>  1629
tgataactcc tggcacaacc attaagaccc tcatctatag tggactggaa caaagcacag     60

gtgactgtaa cacagattga tgaaagattc tgcaggacga caaaggttaa agatgtagac    120

ccggagctag aagccagcac tgacactgat ggagtggact gcgatgagaa tgcccacatt    180

attgtcctat cctctgataa ccaatgtaat atgaaaaccg actacagaag aaaggaacaa    240

attaaatcca ttaatcaagc atatctctgc t                                   271


<210>  1630
<211>  582
<212>  DNA
<213>  Homo sapiens

<400>  1630
acaaccatta agaccctcat ctatagtgga ctggaacaaa gcacaggtga ctgtaacaca     60

gattgatgaa agattctgca ggacgacaaa ggttaaagat gtagacccgg agctagaagc    120

cagcactgac actgatggag tggactgcga tgagaatgcc cacattattg tcctatcctc    180

tgataaccaa tgtaatatga aaaccgacta cagaagaaag gaacaaatta aatccattaa    240

tcaagcatat ctctgctaaa cagttgttcg aaactgatga acaaatgaaa aatttactgt    300

ttgttttcat gcttgcaagg attggggaag aaaattaatt ataaggtact ggccacacta    360

tcagtaaagt ttttcttgag gaaactattg ctttgtcaaa ggacaaatga acctcattag    420

ggagattagt ttcagctggt agttttgcat tagtacaaac taataataca cacttcaaaa    480

gataccctga gtaagattat gaaaattgaa atccatttgt tacttcttaa tttactaact    540

gttagaaaat gaccactcta ttacttatca tgaaaccaga ag                       582


<210>  1631
<211>  43
<212>  PRT
<213>  Homo sapiens

<400>  1631


Lys Ile Tyr Cys Leu Phe Ser Cys Leu Gln Gly Leu Gly Lys Lys Ile 
1               5                   10                  15      


Asn Tyr Lys Val Leu Ala Thr Leu Ser Val Lys Phe Phe Leu Arg Lys 
            20                  25                  30          


Leu Leu Leu Cys Gln Arg Thr Asn Glu Pro His 
        35                  40              

<210>  1632
<211>  1261
<212>  DNA
<213>  Homo sapiens

<400>  1632
aaaagagcaa atgcatagca ttggcactgg tggtgtgaaa gcacagccca ggatgcctct     60

tcagtcacag tcacccacta aagctattcg atgagcacct agcatgggct aggtacctag    120

accaacacac agtttcacca acatccctgg ctaaggtcac gtgatccaca gagatgcttg    180

tttgctgagc atgagtcaga tctggagaaa gtcctgagaa agtcccaagg cttctatgtc    240

tgaagttcca agccaggatg gaagcagcca attcacctgc tatagactaa gtgtttgtgt    300

cttcctcccc tcaatttata tgctgaaacc ctaaccctca tggtacttgg aggtaggggc    360

tgggttagat taagtcatga gggtgagggt ggggccctca tgatgggctg aatgccctca    420

ttaaagaaat ggagaaacat gagatctctc tctccaccat gcgaggatac agcaagaaga    480

cggctatctg ccaaccagga agacagccct cactagacac aggatctgcc agcactttca    540

tcttgggctt cccagcctcc acaactgtaa gaaataaatg tctgtggctt aagccactca    600

gtcaatagta ttttgatata gcagcttggg ctgagatatc acctgtatcg attctttggc    660

aatggattca gcaaatggtg gctttgtaga atgatcagtt aactgcaggg atcagtcgtc    720

agacggagct aaaaagtccc atgctcgggg agcctcaccg gagttccagg aaaatgttaa    780

gaagaagaat aacaacttaa gcttctacac gtcctaaccc tgcaccaaat gctttaggta    840

cggtgttatt catttaaatc ccagaacatg caacagcagg tttcatcaga tatattttat    900

ccagggggta tataaggctc agagaataaa aaggatatcc aaggtcacca ggttgcaacc    960

aatacaggca ggtttcaacc caattcctct gactcaaagc cctggctctg ttctccacgg   1020

ctgtgccaag gaagactgtg ccgaagatac ctttttggtc tcagattgtt gaattttcct   1080

tgactcctgg gaaacagttt aaagcagccg caaacatggt ttccacaact gcattcctga   1140

agcgcatacc cagagttact tcttgtaaca gcactttctt ccagatgact gagatgcgtc   1200

tgctggtgat aagatcagat taacctattt caacttgata gctagattct gacacactga   1260

a                                                                   1261


<210>  1633
<211>  59
<212>  PRT
<213>  Homo sapiens

<400>  1633


Met Glu Lys His Glu Ile Ser Leu Ser Thr Met Arg Gly Tyr Ser Lys 
1               5                   10                  15      


Lys Thr Ala Ile Cys Gln Pro Gly Arg Gln Pro Ser Leu Asp Thr Gly 
            20                  25                  30          


Ser Ala Ser Thr Phe Ile Leu Gly Phe Pro Ala Ser Thr Thr Val Arg 
        35                  40                  45              


Asn Lys Cys Leu Trp Leu Lys Pro Leu Ser Gln 
    50                  55                  

<210>  1634
<211>  404
<212>  DNA
<213>  Homo sapiens

<400>  1634
atatttaatt ttacttggct gggcgcggtg gtggagtgtt tttaatctta tgcaaatatt     60

aatgacactt ggggggaata tagcttcctg agttaaatgc tgcactttgc tacagaagag    120

ggcaggtaag gtcacagact ttaaaacagt aaaatataaa gcaaactatt tacatgaccg    180

aggagtgatt ataaatatca aaggtaagaa gacatttttt gataagataa aaacataaac    240

ataattacta aatgccaaca aaactgagga atcataatat gttaaggtaa aaccaaaata    300

aatgcttgta gcactcaata tctcaaacct atgtatcttt aagaacaaat atatttcttt    360

gaaatattct ataaagatta gaagttatta gcccagagtt ctta                     404


<210>  1635
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  1635


Val Lys Cys Cys Thr Leu Leu Gln Lys Arg Ala Gly Lys Val Thr Asp 
1               5                   10                  15      


Phe Lys Thr Val Lys Tyr Lys Ala Asn Tyr Leu His Asp Arg Gly Val 
            20                  25                  30          


Ile Ile Asn Ile Lys Gly Lys Lys Thr Phe Phe Asp Lys Ile Lys Thr 
        35                  40                  45              

<210>  1636
<211>  3850
<212>  DNA
<213>  Homo sapiens

<400>  1636
caatttccaa gaatgatgcc tttcaggtcc tagggcctct ggcctctagg taaccagttt     60

aaattggttc agggtgataa ctacttagca ctgccctggt gattacccag agatatctat    120

gaaaaccagt ggcttccatc aaacctttgc caactcaggt tcacagcagc tttgggcagt    180

tatggcagta tggcattagc tgagaggtgt ctgccacttc tgggtcaatg gaataataaa    240

ttaagtacag gcaggaattt ggttgggagc atcttgtatg atctccgtat gatgtgatat    300

tgatggagat agtggtcctc attcttgggg gttgccattc ccacattccc ccttcaacaa    360

acagtgtaac aggtccttcc cagatttagg gtacttttat tgatggatat gttttccttt    420

tattcacata accccttgaa accctgtctt gtcctcctgt tacttgcttc tgctgtacaa    480

gatgtagcac cttttctcct ctttgaacat ggtctagtga cacggtagca ccagttgcag    540

gaaggagcca gacttgttct cagagcactg tgttcacact tttcagcaaa aatagctatg    600

gttgtaacat atgtattccc ttcctctgat ttgaaggcaa aaatctacag tgtttcttca    660

cttcttttct gatctggggc atgaaaaaag caagattgaa atttgaacta tgagtctcct    720

gcatggcaac aaaatgtgtg tcaccatcag gccaacaggc cagcccttga atggggattt    780

attactgttg tatctatgtt gcatgataaa cattcatcac cttcctcctg tagtcctgcc    840

tcgtactccc cttcccctat gattgaaaag taaacaaaac ccacatttcc tatcctggtt    900

agaagaaaat taatgttctg acagttgtga tcgcctggag tacttttaga cttttagcat    960

tcgtttttta cctgtttgtg gatgtgtgtt tgtatgtgca tacgtatgag ataggcacat   1020

gcatcttctg tatggacaaa ggtggggtac ctacaggaga gcaaaggtta attttgtgct   1080

tttagtaaaa acatttaaat acaaagttct ttattgggtg gaattatatt tgatgcaaat   1140

atttgatcac ttaaaacttt taaaacttct aggtaatttg ccacgctttt tgactgctca   1200

ccaataccct gtaaaaatac gtaattcttc ctgtttgtgt aataagatat tcatatttgt   1260

agttgcatta ataatagtta tttcttagtc catcagatgt tcccgtgtgc ctcttttatg   1320

ccaaattgat tgtcatattt catgttggga ccaagtagtt tgcccatggc aaacctaaat   1380

ttatgacctg ctgaggcctc tcagaaaact gagcatacta gcaagacagc tcttcttgaa   1440

aaaaaaaatt tgattgtgta gctgtccaaa ataataacat atatagaggg agctgtattc   1500

ctttatacaa atctgatggc tcctgcagca ctttttcctt ctgaaaatat ttacattttg   1560

ctaacctagt ttgttacttt aaaaatcagt tttgatgaaa ggagggaaaa gcagatggac   1620

ttgaaaaaga tccaagctcc tattagaaaa ggtatgaaaa tctttatagt aaaatttttt   1680

ataaactaaa gttgtacctt ttaatatgta gtaaactctc atttatttgg ggttcgctct   1740

tggatctcat ccatccattg tgttctcttt aatgctgcct gccttttgag gcattcactg   1800

ccctagacaa tgccaccaga gatagtgggg gaaatgccag atgaaaccaa ctcttgctct   1860

cactagttgt cagcttctct ggataagtga ccacagaagc aggagtcctc ctgcttgggc   1920

atcattgggc cagttccttc tctttaaatc agatttgtaa tggctcccaa attccatcac   1980

atcacattta aattgcagac agtgttttgc acatcatgta tctgttttgt cccataatat   2040

gctttttact ccctgatccc agtttctgct gttgactctt ccattcagtt ttatttattg   2100

tgtgttctca cagtgacacc atttgtcctt ttctgcaaca acctttccag ctacttttgc   2160

caaattctat ttgtcttctc cttcaaaaca ttctcctttg cagttcctct tcatctgtgt   2220

agctgctctt ttgtctctta acttaccatt cctatagtac tttatgcatc tctgcttagt   2280

tctattagtt ttttggcctt gctcttctcc ttgattttaa aattccttct atagctagag   2340

cttttctttc tttcattctc tcttcctgca gtgttttgca tacatcagaa gctaggtaca   2400

taagttaaat gattgagagt tggctgtatt tagatttatc actttttaat agggtgagct   2460

tgagagtttt ctttctttct gttttttttt tttgtttttt tttttttttt tttttttttt   2520

ttttttgact aatttcacat gctctaaaaa ccttcaaagg tgattatttt tctcctggaa   2580

actccaggtc cattctgttt aaatccctaa gaatgtcaga attaaaataa cagggctatc   2640

ccgtaattgg aaatatttct tttttcagga tgctatagtc aatttagtaa gtgaccacca   2700

aattgttatt tgcactaaca aagctcaaaa cacgataagt ttactcctcc atctcagtaa   2760

taaaaattaa gctgtaatca accttctagg tttctcttgt cttaaaatgg gtattcaaaa   2820

atggggatct gtggtgtatg tatggaaaca catactcctt aatttacctg ttgttggaaa   2880

ctggagaaat gattgtcggg caaccgttta ttttttattg tattttattt ggttgaggga   2940

tttttttata aacagtttta cttgtgtcat attttaaaat tactaactgc catcacctgc   3000

tggggtcctt tgttaggtca ttttcagtga ctaataggga taatccaggt aactttgaag   3060

agatgagcag tgagtgacca ggcagttttt ctgcctttag ctttgacagt tcttaattaa   3120

gatcattgaa gaccagcttt ctcataaatt tctctttttg aaaaaaagaa agcatttgta   3180

ctaagctcct ctgtaagaca acatcttaaa tcttaaaagt gttgttatca tgactggtga   3240

gagaagaaaa cattttgttt ttattaaatg gagcattatt tacaaaaagc cattgttgag   3300

aattagatcc cacatcgtat aaatatctat taaccattct aaataaagag aactccagtg   3360

ttgctatgtg caagatcctc tcttggagct tttttgcata gcaattaaag gtgtgctatt   3420

tgtcagtagc catttttttg cagtgatttg aagaccaaag ttgttttaca gctgtgttac   3480

cgttaaaggt tttttttttt atatgtatta aatcaattta tcactgttta aagctttgaa   3540

tatctgcaat ctttgccaag gtactttttt atttaaaaaa aaacataact ttgtaaatat   3600

taccctgtaa tattatatat acttaataaa acattttaag ctattttgtt gggctatttc   3660

tattgctgct acagcagacc acaagcacat ttctgaaaaa tttaatttat taatgtattt   3720

ttaagttgct tatattctag gtaacaatgt aaagaatgat ttaaaatatt aattatgaat   3780

tttttgagta taatacccaa taagctttta attagagcag agttttaatt aaaagtttta   3840

aatcagtcca                                                          3850


<210>  1637
<211>  89
<212>  PRT
<213>  Homo sapiens

<400>  1637


Met His Leu Leu Tyr Gly Gln Arg Trp Gly Thr Tyr Arg Arg Ala Lys 
1               5                   10                  15      


Val Asn Phe Val Leu Leu Val Lys Thr Phe Lys Tyr Lys Val Leu Tyr 
            20                  25                  30          


Trp Val Glu Leu Tyr Leu Met Gln Ile Phe Asp His Leu Lys Leu Leu 
        35                  40                  45              


Lys Leu Leu Gly Asn Leu Pro Arg Phe Leu Thr Ala His Gln Tyr Pro 
    50                  55                  60                  


Val Lys Ile Arg Asn Ser Ser Cys Leu Cys Asn Lys Ile Phe Ile Phe 
65                  70                  75                  80  


Val Val Ala Leu Ile Ile Val Ile Ser 
                85                  

<210>  1638
<211>  4158
<212>  DNA
<213>  Homo sapiens

<400>  1638
acgaatagtg attatgtgtt catttttcaa ttttccagaa taactgaagt gaagtgatgg     60

actccgattt ggagagtagt aagacgtgaa aggaatacac ttgtgtttaa gcaccatggc    120

cttgatgatt cactgttggg gagaagaaac aagaaaagta actggttgtc acctatgaga    180

cccttacgtg attgttagtt aagtttttat tcaaagcagc tgtaatttag ttaataaaat    240

aattatgatc tatgttgttt gcccaattga gatccagttt tttgttgtta tttttaatca    300

attaggggca atagtagaat ggacaatttc caagaatgat gcctttcagg tcctagggcc    360

tctggcctct aggtaaccag tttaaattgg ttcagggtga taactactta gcactgccct    420

ggtgattacc cagagatatc tatgaaaacc agtggcttcc atcaaacctt tgccaactca    480

ggttcacagc agctttgggc agttatggca gtatggcatt agctgagagg tgtctgccac    540

ttctgggtca atggaataat aaattaagta caggcaggaa tttggttggg agcatcttgt    600

atgatctccg tatgatgtga tattgatgga gatagtggtc ctcattcttg ggggttgcca    660

ttcccacatt cccccttcaa caaacagtgt aacaggtcct tcccagattt agggtacttt    720

tattgatgga tatgttttcc ttttattcac ataacccctt gaaaccctgt cttgtcctcc    780

tgttacttgc ttctgctgta caagatgtag caccttttct cctctttgaa catggtctag    840

tgacacggta gcaccagttg caggaaggag ccagacttgt tctcagagca ctgtgttcac    900

acttttcagc aaaaatagct atggttgtaa catatgtatt cccttcctct gatttgaagg    960

caaaaatcta cagtgtttct tcacttcttt tctgatctgg ggcatgaaaa aagcaagatt   1020

gaaatttgaa ctatgagtct cctgcatggc aacaaaatgt gtgtcaccat caggccaaca   1080

ggccagcctc cccttcccct atgattgaaa agtaaacaaa acccacattt cctatcctgg   1140

ttagaagaaa attaatgttc tgacagttgt gatcgcctgg agtactttta gacttttagc   1200

attcgttttt tacctgtttg tggatgtgtg tttgtatgtg catacgtatg agataggcac   1260

atgcatcttc tgtatggaca aaggtggggt acctacagga gagcaaaggt taattttgtg   1320

cttttagtaa aaacatttaa atacaaagtt ctttattggg tggaattata tttgatgcaa   1380

atatttgatc acttaaaact tttaaaactt ctaggtaatt tgccacgctt tttgactgct   1440

caccaatacc ctgtaaaaat acgtaattct tcctgtttgt gtaataagat attcatattt   1500

gtagttgcat taataatagt tatttcttag tccatcagat gttcccgtgt gcctctttta   1560

tgccaaattg attgtcatat ttcatgttgg gaccaagtag tttgcccatg gcaaacctaa   1620

atttatgacc tgctgaggcc tctcagaaaa ctgagcatac tagcaagaca gctcttcttg   1680

aaaaaaaaaa tatgtataca caaatatata cgtatatcta tatatacgta tgtatataca   1740

cacatgtata ttcttccttg attgtgtagc tgtccaaaat aataacatat atagagggag   1800

ctgtattcct ttatacaaat ctgatggctc ctgcagcact ttttccttct gaaaatattt   1860

acattttgct aacctagttt gttactttaa aaatcagttt tgatgaaagg agggaaaagc   1920

agatggactt gaaaaagatc caagctccta ttagaaaagg tatgaaaatc tttatagtaa   1980

aattttttat aaactaaagt tgtacctttt aatatgtagt aaactctcat ttatttgggg   2040

ttcgctcttg gatctcatcc atccattgtg ttctctttaa tgctgcctgc cttttgaggc   2100

attcactgcc ctagacaatg ccaccagaga tagtggggga aatgccagat gaaaccaact   2160

cttgctctca ctagttgtca gcttctctgg ataagtgacc acagaagcag gagtcctcct   2220

gcttgggcat cattgggcca gttccttctc tttaaatcag atttgtaatg gctcccaaat   2280

tccatcacat cacatttaaa ttgcagacag tgttttgcac atcatgtatc tgttttgtcc   2340

cataatatgc tttttactcc ctgatcccag tttctgctgt tgactcttcc attcagtttt   2400

atttattgtg tgttctcaca gtgacaccat ttgtcctttt ctgcaacaac ctttccagct   2460

acttttgcca aattctattt gtcttctcct tcaaaacatt ctcctttgca gttcctcttc   2520

atctgtgtag ctgctctttt gtctcttaac ttaccattcc tatagtactt tatgcatctc   2580

tgcttagttc tattagtttt ttggccttgc tcttctcctt gattttaaaa ttccttctat   2640

agctagagct tttctttctt tcattctctc ttcctgcagt gttttgcata catcagaagc   2700

taggtacata agttaaatga ttgagagttg gctgtattta gatttatcac tttttaatag   2760

ggtgagcttg agagttttct ttctttctgt tttttttttt tgtttttttt tttttttttt   2820

tttttttttt ttttgactaa tttcacatgc tctaaaaacc ttcaaaggtg attatttttc   2880

tcctggaaac tccaggtcca ttctgtttaa atccctaaga atgtcagaat taaaataaca   2940

gggctatccc gtaattggaa atatttcttt tttcaggatg ctatagtcaa tttagtaagt   3000

gaccaccaaa ttgttatttg cactaacaaa gctcaaaaca cgataagttt actcctccat   3060

ctcagtaata aaaattaagc tgtaatcaac cttctaggtt tctcttgtct taaaatgggt   3120

attcaaaaat ggggatctgt ggtgtatgta tggaaacaca tactccttaa tttacctgtt   3180

gttggaaact ggagaaatga ttgtcgggca accgtttatt ttttattgta ttttatttgg   3240

ttgagggatt tttttataaa cagttttact tgtgtcatat tttaaaatta ctaactgcca   3300

tcacctgctg gggtcctttg ttaggtcatt ttcagtgact aatagggata atccaggtaa   3360

ctttgaagag atgagcagtg agtgaccagg cagtttttct gcctttagct ttgacagttc   3420

ttaattaaga tcattgaaga ccagctttct cataaatttc tctttttgaa aaaaagaaag   3480

catttgtact aagctcctct gtaagacaac atcttaaatc ttaaaagtgt tgttatcatg   3540

actggtgaga gaagaaaaca ttttgttttt attaaatgga gcattattta caaaaagcca   3600

ttgttgagaa ttagatccca catcgtataa atatctatta accattctaa ataaagagaa   3660

ctccagtgtt gctatgtgca agatcctctc ttggagcttt tttgcatagc aattaaaggt   3720

gtgctatttg tcagtagcca tttttttgca gtgatttgaa gaccaaagtt gttttacagc   3780

tgtgttaccg ttaaaggttt ttttttttat atgtattaaa tcaatttatc actgtttaaa   3840

gctttgaata tctgcaatct ttgccaaggt acttttttat ttaaaaaaaa acataacttt   3900

gtaaatatta ccctgtaata ttatatatac ttaataaaac attttaagct attttgttgg   3960

gctatttcta ttgctgctac agcagaccac aagcacattt ctgaaaaatt taatttatta   4020

atgtattttt aagttgctta tattctaggt aacaatgtaa agaatgattt aaaatattaa   4080

ttatgaattt tttgagtata atacccaata agcttttaat tagagcagag ttttaattaa   4140

aagttttaaa tcagtcca                                                 4158


<210>  1639
<211>  89
<212>  PRT
<213>  Homo sapiens

<400>  1639


Met His Leu Leu Tyr Gly Gln Arg Trp Gly Thr Tyr Arg Arg Ala Lys 
1               5                   10                  15      


Val Asn Phe Val Leu Leu Val Lys Thr Phe Lys Tyr Lys Val Leu Tyr 
            20                  25                  30          


Trp Val Glu Leu Tyr Leu Met Gln Ile Phe Asp His Leu Lys Leu Leu 
        35                  40                  45              


Lys Leu Leu Gly Asn Leu Pro Arg Phe Leu Thr Ala His Gln Tyr Pro 
    50                  55                  60                  


Val Lys Ile Arg Asn Ser Ser Cys Leu Cys Asn Lys Ile Phe Ile Phe 
65                  70                  75                  80  


Val Val Ala Leu Ile Ile Val Ile Ser 
                85                  

<210>  1640
<211>  4828
<212>  DNA
<213>  Homo sapiens

<400>  1640
gaaaaaggca actcagaaag ctaagaagaa atagatagag gaatactcag agctatctga     60

gtattttctt tagtttgtta gctctttgga gctttgaaac tggaaagacc cagggagtga    120

tgtggagaaa gagactgagc ttgtaagaca caggagcagt gagctaaggg agatggagta    180

gtggggacaa attctggcac attctgtcta cactctgggt agatagagga gggaggatgg    240

agcacccatg gtgggggtat gttggtgaca gcattttccc accagccagt gtaacaagtg    300

gctgatttgg gggaaagatg gcataaacaa atgagagaat gtgtttacta tttgatgtag    360

atgggttatt tgcttcattt ttcaaatcag tgtatataat caagaatatt cagcatgttt    420

gaatagactg tcagagctgg aactctttca ttaacatctc tggcaccttt agttttagcc    480

ctgaacattt tatcttaaaa ttaaacatta ccaaatgcct tagtttattt catttattaa    540

atttatattc ttatttgtta tttatatcag cttccaatca gaagactata caacctccta    600

ggaaagctgt agaggaaccc cttaatgaat aactgaagtg aagtgatgga ctccgatttg    660

gagagtagta agacgtgaaa ggaatacact tgtgtttaag caccatggcc ttgatgattc    720

actgttgggg agaagaaaca agaaaagtaa ctggttgtca cctatgagac ccttacgtga    780

ttgttagtta agtttttatt caaagcagct gtaatttagt taataaaata attatgatct    840

atgttgtttg cccaattgag atccagtttt ttgttgttat ttttaatcaa ttaggggcaa    900

tagtagaatg gacaatttcc aagaatgatg cctttcaggt cctagggcct ctggcctcta    960

ggtaaccagt ttaaattggt tcagggtgat aactacttag cactgccctg gtgattaccc   1020

agagatatct atgaaaacca gtggcttcca tcaaaccttt gccaactcag gttcacagca   1080

gctttgggca gttatggcag tatggcatta gctgagaggt gtctgccact tctgggtcaa   1140

tggaataata aattaagtac aggcaggaat ttggttggga gcatcttgta tgatctccgt   1200

atgatgtgat attgatggag atagtggtcc tcattcttgg gggttgccat tcccacattc   1260

ccccttcaac aaacagtgta acaggtcctt cccagattta gggtactttt attgatggat   1320

atgttttcct tttattcaca taaccccttg aaaccctgtc ttgtcctcct gttacttgct   1380

tctgctgtac aagatgtagc accttttctc ctctttgaac atggtctagt gacacggtag   1440

caccagttgc aggaaggagc cagacttgtt ctcagagcac tgtgttcaca cttttcagca   1500

aaaatagcta tggttgtaac atatgtattc ccttcctctg atttgaaggc aaaaatctac   1560

agtgtttctt cacttctttt ctgatctggg gcatgaaaaa agcaagattg aaatttgaac   1620

tatgagtctc ctgcatggca acaaaatgtg tgtcaccatc aggccaacag gccagccctt   1680

gaatggggat ttattactgt tgtatctatg ttgcatgata aacattcatc accttcctcc   1740

tgtagtcctg cctcgtactc cccttcccct atgattgaaa agtaaacaaa acccacattt   1800

cctatcctgg ttagaagaaa attaatgttc tgacagttgt gatcgcctgg agtactttta   1860

gacttttagc attcgttttt tacctgtttg tggatgtgtg tttgtatgtg catacgtatg   1920

agataggcac atgcatcttc tgtatggaca aaggtggggt acctacagga gagcaaaggt   1980

taattttgtg cttttagtaa aaacatttaa atacaaagtt ctttattggg tggaattata   2040

tttgatgcaa atatttgatc acttaaaact tttaaaactt ctaggtaatt tgccacgctt   2100

tttgactgct caccaatacc ctgtaaaaat acgtaattct tcctgtttgt gtaataagat   2160

attcatattt gtagttgcat taataatagt tatttcttag tccatcagat gttcccgtgt   2220

gcctctttta tgccaaattg attgtcatat ttcatgttgg gaccaagtag tttgcccatg   2280

gcaaacctaa atttatgacc tgctgaggcc tctcagaaaa ctgagcatac tagcaagaca   2340

gctcttcttg aaaaaaaaaa tatgtataca caaatatata cgtatatcta tatatacgta   2400

tgtatataca cacatgtata ttcttccttg attgtgtagc tgtccaaaat aataacatat   2460

atagagggag ctgtattcct ttatacaaat ctgatggctc ctgcagcact ttttccttct   2520

gaaaatattt acattttgct aacctagttt gttactttaa aaatcagttt tgatgaaagg   2580

agggaaaagc agatggactt gaaaaagatc caagctccta ttagaaaagg tatgaaaatc   2640

tttatagtaa aattttttat aaactaaagt tgtacctttt aatatgtagt aaactctcat   2700

ttatttgggg ttcgctcttg gatctcatcc atccattgtg ttctctttaa tgctgcctgc   2760

cttttgaggc attcactgcc ctagacaatg ccaccagaga tagtggggga aatgccagat   2820

gaaaccaact cttgctctca ctagttgtca gcttctctgg ataagtgacc acagaagcag   2880

gagtcctcct gcttgggcat cattgggcca gttccttctc tttaaatcag atttgtaatg   2940

gctcccaaat tccatcacat cacatttaaa ttgcagacag tgttttgcac atcatgtatc   3000

tgttttgtcc cataatatgc tttttactcc ctgatcccag tttctgctgt tgactcttcc   3060

attcagtttt atttattgtg tgttctcaca gtgacaccat ttgtcctttt ctgcaacaac   3120

ctttccagct acttttgcca aattctattt gtcttctcct tcaaaacatt ctcctttgca   3180

gttcctcttc atctgtgtag ctgctctttt gtctcttaac ttaccattcc tatagtactt   3240

tatgcatctc tgcttagttc tattagtttt ttggccttgc tcttctcctt gattttaaaa   3300

ttccttctat agctagagct tttctttctt tcattctctc ttcctgcagt gttttgcata   3360

catcagaagc taggtacata agttaaatga ttgagagttg gctgtattta gatttatcac   3420

tttttaatag ggtgagcttg agagttttct ttctttctgt tttttttttt tgtttttttt   3480

tttttttttt tttttttttt ttttgactaa tttcacatgc tctaaaaacc ttcaaaggtg   3540

attatttttc tcctggaaac tccaggtcca ttctgtttaa atccctaaga atgtcagaat   3600

taaaataaca gggctatccc gtaattggaa atatttcttt tttcaggatg ctatagtcaa   3660

tttagtaagt gaccaccaaa ttgttatttg cactaacaaa gctcaaaaca cgataagttt   3720

actcctccat ctcagtaata aaaattaagc tgtaatcaac cttctaggtt tctcttgtct   3780

taaaatgggt attcaaaaat ggggatctgt ggtgtatgta tggaaacaca tactccttaa   3840

tttacctgtt gttggaaact ggagaaatga ttgtcgggca accgtttatt ttttattgta   3900

ttttatttgg ttgagggatt tttttataaa cagttttact tgtgtcatat tttaaaatta   3960

ctaactgcca tcacctgctg gggtcctttg ttaggtcatt ttcagtgact aatagggata   4020

atccaggtaa ctttgaagag atgagcagtg agtgaccagg cagtttttct gcctttagct   4080

ttgacagttc ttaattaaga tcattgaaga ccagctttct cataaatttc tctttttgaa   4140

aaaaagaaag catttgtact aagctcctct gtaagacaac atcttaaatc ttaaaagtgt   4200

tgttatcatg actggtgaga gaagaaaaca ttttgttttt attaaatgga gcattattta   4260

caaaaagcca ttgttgagaa ttagatccca catcgtataa atatctatta accattctaa   4320

ataaagagaa ctccagtgtt gctatgtgca agatcctctc ttggagcttt tttgcatagc   4380

aattaaaggt gtgctatttg tcagtagcca tttttttgca gtgatttgaa gaccaaagtt   4440

gttttacagc tgtgttaccg ttaaaggttt ttttttttat atgtattaaa tcaatttatc   4500

actgtttaaa gctttgaata tctgcaatct ttgccaaggt acttttttat ttaaaaaaaa   4560

acataacttt gtaaatatta ccctgtaata ttatatatac ttaataaaac attttaagct   4620

attttgttgg gctatttcta ttgctgctac agcagaccac aagcacattt ctgaaaaatt   4680

taatttatta atgtattttt aagttgctta tattctaggt aacaatgtaa agaatgattt   4740

aaaatattaa ttatgaattt tttgagtata atacccaata agcttttaat tagagcagag   4800

ttttaattaa aagttttaaa tcagtcca                                      4828


<210>  1641
<211>  89
<212>  PRT
<213>  Homo sapiens

<400>  1641


Met His Leu Leu Tyr Gly Gln Arg Trp Gly Thr Tyr Arg Arg Ala Lys 
1               5                   10                  15      


Val Asn Phe Val Leu Leu Val Lys Thr Phe Lys Tyr Lys Val Leu Tyr 
            20                  25                  30          


Trp Val Glu Leu Tyr Leu Met Gln Ile Phe Asp His Leu Lys Leu Leu 
        35                  40                  45              


Lys Leu Leu Gly Asn Leu Pro Arg Phe Leu Thr Ala His Gln Tyr Pro 
    50                  55                  60                  


Val Lys Ile Arg Asn Ser Ser Cys Leu Cys Asn Lys Ile Phe Ile Phe 
65                  70                  75                  80  


Val Val Ala Leu Ile Ile Val Ile Ser 
                85                  

<210>  1642
<211>  4944
<212>  DNA
<213>  Homo sapiens

<400>  1642
ctagggtatt ctttttccct ttcgtcactt tgctcatgta ctgtattcct tcaacttcat     60

taatgaatcc atttggaagc agtgaaaaag gcaactcaga aagctaagaa gaaatagata    120

gaggaatact cagagctatc tgagtatttt ctttagtttg ttagctcttt ggagctttga    180

aactggaaag acccagggag tgatgtggag aaagagactg agcttgtaag acacaggagc    240

agtgagctaa gggagatgga gtagtgggga caaattctgg cacattctgt ctacactctg    300

ggtagataga ggagggagga tggagcaccc atggtggggg tatgttggtg acagcatttt    360

cccaccagcc agtgtaacaa gtggctgatt tgggggaaag atggcataaa caaatgagag    420

aatgtgttta ctatttgatg tagatgggtt atttgcttca tttttcaaat cagtgtatat    480

aatcaagaat attcagcatg tttgaataga ctgtcagagc tggaactctt tcattaacat    540

ctctggcacc tttagtttta gccctgaaca ttttatctta aaattaaaca ttaccaaatg    600

ccttagttta tttcatttat taaatttata ttcttatttg ttatttatat cagcttccaa    660

tcagaagact atacaacctc ctaggaaagc tgtagaggaa ccccttaatg cattcaaaga    720

atcaaaagga atgatgaatg atgaataact gaagtgaagt gatggactcc gatttggaga    780

gtagtaagac gtgaaaggaa tacacttgtg tttaagcacc atggccttga tgattcactg    840

ttggggagaa gaaacaagaa aagtaactgg ttgtcaccta tgagaccctt acgtgattgt    900

tagttaagtt tttattcaaa gcagctgtaa tttagttaat aaaataatta tgatctatgt    960

tgtttgccca attgagatcc agttttttgt tgttattttt aatcaattag gggcaatagt   1020

agaatggaca atttccaaga atgatgcctt tcaggtccta gggcctctgg cctctaggta   1080

accagtttaa attggttcag ggtgataact acttagcact gccctggtga ttacccagag   1140

atatctatga aaaccagtgg cttccatcaa acctttgcca actcaggttc acagcagctt   1200

tgggcagtta tggcagtatg gcattagctg agaggtgtct gccacttctg ggtcaatgga   1260

ataataaatt aagtacaggc aggaatttgg ttgggagcat cttgtatgat ctccgtatga   1320

tgtgatattg atggagatag tggtcctcat tcttgggggt tgccattccc acattccccc   1380

ttcaacaaac agtgtaacag gtccttccca gatttagggt acttttattg atggatatgt   1440

tttcctttta ttcacataac cccttgaaac cctgtcttgt cctcctgtta cttgcttctg   1500

ctgtacaaga tgtagcacct tttctcctct ttgaacatgg tctagtgaca cggtagcacc   1560

agttgcagga aggagccaga cttgttctca gagcactgtg ttcacacttt tcagcaaaaa   1620

tagctatggt tgtaacatat gtattccctt cctctgattt gaaggcaaaa atctacagtg   1680

tttcttcact tcttttctga tctggggcat gaaaaaagca agattgaaat ttgaactatg   1740

agtctcctgc atggcaacaa aatgtgtgtc accatcaggc caacaggcca gcccttgaat   1800

ggggatttat tactgttgta tctatgttgc atgataaaca ttcatcacct tcctcctgta   1860

gtcctgcctc gtactcccct tcccctatga ttgaaaagta aacaaaaccc acatttccta   1920

tcctggttag aagaaaatta atgttctgac agttgtgatc gcctggagta cttttagact   1980

tttagcattc gttttttacc tgtttgtgga tgtgtgtttg tatgtgcata cgtatgagat   2040

aggcacatgc atcttctgta tggacaaagg tggggtacct acaggagagc aaaggttaat   2100

tttgtgcttt tagtaaaaac atttaaatac aaagttcttt attgggtgga attatatttg   2160

atgcaaatat ttgatcactt aaaactttta aaacttctag gtaatttgcc acgctttttg   2220

actgctcacc aataccctgt aaaaatacgt aattcttcct gtttgtgtaa taagatattc   2280

atatttgtag ttgcattaat aatagttatt tcttagtcca tcagatgttc ccgtgtgcct   2340

cttttatgcc aaattgattg tcatatttca tgttgggacc aagtagtttg cccatggcaa   2400

acctaaattt atgacctgct gaggcctctc agaaaactga gcatactagc aagacagctc   2460

ttcttgaaaa aaaaaatatg tatacacaaa tatatacgta tatctatata tacgtatgta   2520

tatacacaca tgtatattct tccttgattg tgtagctgtc caaaataata acatatatag   2580

agggagctgt attcctttat acaaatctga tggctcctgc agcacttttt ccttctgaaa   2640

atatttacat tttgctaacc tagtttgtta ctttaaaaat cagttttgat gaaaggaggg   2700

aaaagcagat ggacttgaaa aagatccaag ctcctattag aaaaggtatg aaaatcttta   2760

tagtaaaatt ttttataaac taaagttgta ccttttaata tgtagtaaac tctcatttat   2820

ttggggttcg ctcttggatc tcatccatcc attgtgttct ctttaatgct gcctgccttt   2880

tgaggcattc actgccctag acaatgccac cagagatagt gggggaaatg ccagatgaaa   2940

ccaactcttg ctctcactag ttgtcagctt ctctggataa gtgaccacag aagcaggagt   3000

cctcctgctt gggcatcatt gggccagttc cttctcttta aatcagattt gtaatggctc   3060

ccaaattcca tcacatcaca tttaaattgc agacagtgtt ttgcacatca tgtatctgtt   3120

ttgtcccata atatgctttt tactccctga tcccagtttc tgctgttgac tcttccattc   3180

agttttattt attgtgtgtt ctcacagtga caccatttgt ccttttctgc aacaaccttt   3240

ccagctactt ttgccaaatt ctatttgtct tctccttcaa aacattctcc tttgcagttc   3300

ctcttcatct gtgtagctgc tcttttgtct cttaacttac cattcctata gtactttatg   3360

catctctgct tagttctatt agttttttgg ccttgctctt ctccttgatt ttaaaattcc   3420

ttctatagct agagcttttc tttctttcat tctctcttcc tgcagtgttt tgcatacatc   3480

agaagctagg tacataagtt aaatgattga gagttggctg tatttagatt tatcactttt   3540

taatagggtg agcttgagag ttttctttct ttctgttttt tttttttgtt tttttttttt   3600

tttttttttt tttttttttt gactaatttc acatgctcta aaaaccttca aaggtgatta   3660

tttttctcct ggaaactcca ggtccattct gtttaaatcc ctaagaatgt cagaattaaa   3720

ataacagggc tatcccgtaa ttggaaatat ttcttttttc aggatgctat agtcaattta   3780

gtaagtgacc accaaattgt tatttgcact aacaaagctc aaaacacgat aagtttactc   3840

ctccatctca gtaataaaaa ttaagctgta atcaaccttc taggtttctc ttgtcttaaa   3900

atgggtattc aaaaatgggg atctgtggtg tatgtatgga aacacatact ccttaattta   3960

cctgttgttg gaaactggag aaatgattgt cgggcaaccg tttatttttt attgtatttt   4020

atttggttga gggatttttt tataaacagt tttacttgtg tcatatttta aaattactaa   4080

ctgccatcac ctgctggggt cctttgttag gtcattttca gtgactaata gggataatcc   4140

aggtaacttt gaagagatga gcagtgagtg accaggcagt ttttctgcct ttagctttga   4200

cagttcttaa ttaagatcat tgaagaccag ctttctcata aatttctctt tttgaaaaaa   4260

agaaagcatt tgtactaagc tcctctgtaa gacaacatct taaatcttaa aagtgttgtt   4320

atcatgactg gtgagagaag aaaacatttt gtttttatta aatggagcat tatttacaaa   4380

aagccattgt tgagaattag atcccacatc gtataaatat ctattaacca ttctaaataa   4440

agagaactcc agtgttgcta tgtgcaagat cctctcttgg agcttttttg catagcaatt   4500

aaaggtgtgc tatttgtcag tagccatttt tttgcagtga tttgaagacc aaagttgttt   4560

tacagctgtg ttaccgttaa aggttttttt ttttatatgt attaaatcaa tttatcactg   4620

tttaaagctt tgaatatctg caatctttgc caaggtactt ttttatttaa aaaaaaacat   4680

aactttgtaa atattaccct gtaatattat atatacttaa taaaacattt taagctattt   4740

tgttgggcta tttctattgc tgctacagca gaccacaagc acatttctga aaaatttaat   4800

ttattaatgt atttttaagt tgcttatatt ctaggtaaca atgtaaagaa tgatttaaaa   4860

tattaattat gaattttttg agtataatac ccaataagct tttaattaga gcagagtttt   4920

aattaaaagt tttaaatcag tcca                                          4944


<210>  1643
<211>  89
<212>  PRT
<213>  Homo sapiens

<400>  1643


Met His Leu Leu Tyr Gly Gln Arg Trp Gly Thr Tyr Arg Arg Ala Lys 
1               5                   10                  15      


Val Asn Phe Val Leu Leu Val Lys Thr Phe Lys Tyr Lys Val Leu Tyr 
            20                  25                  30          


Trp Val Glu Leu Tyr Leu Met Gln Ile Phe Asp His Leu Lys Leu Leu 
        35                  40                  45              


Lys Leu Leu Gly Asn Leu Pro Arg Phe Leu Thr Ala His Gln Tyr Pro 
    50                  55                  60                  


Val Lys Ile Arg Asn Ser Ser Cys Leu Cys Asn Lys Ile Phe Ile Phe 
65                  70                  75                  80  


Val Val Ala Leu Ile Ile Val Ile Ser 
                85                  

<210>  1644
<211>  4520
<212>  DNA
<213>  Homo sapiens

<400>  1644
gcagaaatcg taataattct tttgtcacat gggttatatc catattggag agaattaact     60

caggtgaaat taacttgtac actgtttggt tttataatat ttagagggat cacaactgac    120

tgatgtccct ttgaagtacc attcttcata aatctttttt tttcagaatg ggccagccaa    180

ctgtgacatc ccttggatcg gagatttaga actagaaagt attctttcta cattattagg    240

gaagaaaagg agttacttgg cgcttccaat cagaagacta tacaacctcc taggaaagct    300

gtagaggaac cccttaatga ataactgaag tgaagtgatg gactccgatt tggagagtag    360

taagacgtga aaggaataca cttgtgttta agcaccatgg ccttgatgat tcactgttgg    420

ggagaagaaa caagaaaagt aactggttgt cacctatgag acccttacgt gattgttagt    480

taagttttta ttcaaagcag ctgtaattta gttaataaaa taattatgat ctatgttgtt    540

tgcccaattg agatccagtt ttttgttgtt atttttaatc aattaggggc aatagtagaa    600

tggacaattt ccaagaatga tgcctttcag gtcctagggc ctctggcctc taggtaacca    660

gtttaaattg gttcagggtg ataactactt agcactgccc tggtgattac ccagagatat    720

ctatgaaaac cagtggcttc catcaaacct ttgccaactc aggttcacag cagctttggg    780

cagttatggc agtatggcat tagctgagag gtgtctgcca cttctgggtc aatggaataa    840

taaattaagt acaggcagga atttggttgg gagcatcttg tatgatctcc gtatgatgtg    900

atattgatgg agatagtggt cctcattctt gggggttgcc attcccacat tcccccttca    960

acaaacagtg taacaggtcc ttcccagatt tagggtactt ttattgatgg atatgttttc   1020

cttttattca cataacccct tgaaaccctg tcttgtcctc ctgttacttg cttctgctgt   1080

acaagatgta gcaccttttc tcctctttga acatggtcta gtgacacggt agcaccagtt   1140

gcaggaagga gccagacttg ttctcagagc actgtgttca cacttttcag caaaaatagc   1200

tatggttgta acatatgtat tcccttcctc tgatttgaag gcaaaaatct acagtgtttc   1260

ttcacttctt ttctgatctg gggcatgaaa aaagcaagat tgaaatttga actatgagtc   1320

tcctgcatgg caacaaaatg tgtgtcacca tcaggccaac aggccagccc ttgaatgggg   1380

atttattact gttgtatcta tgttgcatga taaacattca tcaccttcct cctgtagtcc   1440

tgcctcgtac tccccttccc ctatgattga aaagtaaaca aaacccacat ttcctatcct   1500

ggttagaaga aaattaatgt tctgacagtt gtgatcgcct ggagtacttt tagactttta   1560

gcattcgttt tttacctgtt tgtggatgtg tgtttgtatg tgcatacgta tgagataggc   1620

acatgcatct tctgtatgga caaaggtggg gtacctacag gagagcaaag gttaattttg   1680

tgcttttagt aaaaacattt aaatacaaag ttctttattg ggtggaatta tatttgatgc   1740

aaatatttga tcacttaaaa cttttaaaac ttctaggtaa tttgccacgc tttttgactg   1800

ctcaccaata ccctgtaaaa atacgtaatt cttcctgttt gtgtaataag atattcatat   1860

ttgtagttgc attaataata gttatttctt agtccatcag atgttcccgt gtgcctcttt   1920

tatgccaaat tgattgtcat atttcatgtt gggaccaagt agtttgccca tggcaaacct   1980

aaatttatga cctgctgagg cctctcagaa aactgagcat actagcaaga cagctcttct   2040

tgaaaaaaaa aatatgtata cacaaatata tacgtatatc tatatatacg tatgtatata   2100

cacacatgta tattcttcct tgattgtgta gctgtccaaa ataataacat atatagaggg   2160

agctgtattc ctttatacaa atctgatggc tcctgcagca ctttttcctt ctgaaaatat   2220

ttacattttg ctaacctagt ttgttacttt aaaaatcagt tttgatgaaa ggagggaaaa   2280

gcagatggac ttgaaaaaga tccaagctcc tattagaaaa ggtatgaaaa tctttatagt   2340

aaaatttttt ataaactaaa gttgtacctt ttaatatgta gtaaactctc atttatttgg   2400

ggttcgctct tggatctcat ccatccattg tgttctcttt aatgctgcct gccttttgag   2460

gcattcactg ccctagacaa tgccaccaga gatagtgggg gaaatgccag atgaaaccaa   2520

ctcttgctct cactagttgt cagcttctct ggataagtga ccacagaagc aggagtcctc   2580

ctgcttgggc atcattgggc cagttccttc tctttaaatc agatttgtaa tggctcccaa   2640

attccatcac atcacattta aattgcagac agtgttttgc acatcatgta tctgttttgt   2700

cccataatat gctttttact ccctgatccc agtttctgct gttgactctt ccattcagtt   2760

ttatttattg tgtgttctca cagtgacacc atttgtcctt ttctgcaaca acctttccag   2820

ctacttttgc caaattctat ttgtcttctc cttcaaaaca ttctcctttg cagttcctct   2880

tcatctgtgt agctgctctt ttgtctctta acttaccatt cctatagtac tttatgcatc   2940

tctgcttagt tctattagtt ttttggcctt gctcttctcc ttgattttaa aattccttct   3000

atagctagag cttttctttc tttcattctc tcttcctgca gtgttttgca tacatcagaa   3060

gctaggtaca taagttaaat gattgagagt tggctgtatt tagatttatc actttttaat   3120

agggtgagct tgagagtttt ctttctttct gttttttttt tttgtttttt tttttttttt   3180

tttttttttt ttttttgact aatttcacat gctctaaaaa ccttcaaagg tgattatttt   3240

tctcctggaa actccaggtc cattctgttt aaatccctaa gaatgtcaga attaaaataa   3300

cagggctatc ccgtaattgg aaatatttct tttttcagga tgctatagtc aatttagtaa   3360

gtgaccacca aattgttatt tgcactaaca aagctcaaaa cacgataagt ttactcctcc   3420

atctcagtaa taaaaattaa gctgtaatca accttctagg tttctcttgt cttaaaatgg   3480

gtattcaaaa atggggatct gtggtgtatg tatggaaaca catactcctt aatttacctg   3540

ttgttggaaa ctggagaaat gattgtcggg caaccgttta ttttttattg tattttattt   3600

ggttgaggga tttttttata aacagtttta cttgtgtcat attttaaaat tactaactgc   3660

catcacctgc tggggtcctt tgttaggtca ttttcagtga ctaataggga taatccaggt   3720

aactttgaag agatgagcag tgagtgacca ggcagttttt ctgcctttag ctttgacagt   3780

tcttaattaa gatcattgaa gaccagcttt ctcataaatt tctctttttg aaaaaaagaa   3840

agcatttgta ctaagctcct ctgtaagaca acatcttaaa tcttaaaagt gttgttatca   3900

tgactggtga gagaagaaaa cattttgttt ttattaaatg gagcattatt tacaaaaagc   3960

cattgttgag aattagatcc cacatcgtat aaatatctat taaccattct aaataaagag   4020

aactccagtg ttgctatgtg caagatcctc tcttggagct tttttgcata gcaattaaag   4080

gtgtgctatt tgtcagtagc catttttttg cagtgatttg aagaccaaag ttgttttaca   4140

gctgtgttac cgttaaaggt tttttttttt atatgtatta aatcaattta tcactgttta   4200

aagctttgaa tatctgcaat ctttgccaag gtactttttt atttaaaaaa aaacataact   4260

ttgtaaatat taccctgtaa tattatatat acttaataaa acattttaag ctattttgtt   4320

gggctatttc tattgctgct acagcagacc acaagcacat ttctgaaaaa tttaatttat   4380

taatgtattt ttaagttgct tatattctag gtaacaatgt aaagaatgat ttaaaatatt   4440

aattatgaat tttttgagta taatacccaa taagctttta attagagcag agttttaatt   4500

aaaagtttta aatcagtcca                                               4520


<210>  1645
<211>  89
<212>  PRT
<213>  Homo sapiens

<400>  1645


Met His Leu Leu Tyr Gly Gln Arg Trp Gly Thr Tyr Arg Arg Ala Lys 
1               5                   10                  15      


Val Asn Phe Val Leu Leu Val Lys Thr Phe Lys Tyr Lys Val Leu Tyr 
            20                  25                  30          


Trp Val Glu Leu Tyr Leu Met Gln Ile Phe Asp His Leu Lys Leu Leu 
        35                  40                  45              


Lys Leu Leu Gly Asn Leu Pro Arg Phe Leu Thr Ala His Gln Tyr Pro 
    50                  55                  60                  


Val Lys Ile Arg Asn Ser Ser Cys Leu Cys Asn Lys Ile Phe Ile Phe 
65                  70                  75                  80  


Val Val Ala Leu Ile Ile Val Ile Ser 
                85                  

<210>  1646
<211>  7513
<212>  DNA
<213>  Homo sapiens

<400>  1646
aagaagttaa tgtcgctatg agatttttaa cttttataat ttttattatt tccaacttta     60

aatttgtagc cttaatttgc tattttaaag agtaggcctt tcactttcta caactttctg    120

tgaaagtgac tttcactttc tattttttaa ctttttaaac tgtgttgtat tttttttctt    180

ttattggaag cattttaatt ttataagatg agaaaaagga ctgggcacaa taacttaatg    240

tgaaagcata gaaaagatta caagaaccta accaaactca ctaaagttgg gcttgttgtt    300

tgtagagaac gtttatataa ttataaggat caatactttc tcatttttaa agccattacc    360

agttagttca atataagggc atatagtgtt ttgatacaaa tcaatctggt agcagtaagt    420

accatattta ccacaacatc ccagatattt tagaatgatg cagatgcaga atatatacgt    480

agaatttata tctatgtata gatacaaatt cagatatttt cttgttcaat ttaaggagag    540

gtaaatttgg tatcaataga aaaaatgttt ctgaaaaatt taaaccctgg aaatgtattt    600

atggcatgga gtcagatgtt tcagggagag aagaacaaat caagaagcat tgcaagtatg    660

ctcatatgga atgcttaagg cttgtggtta aaaaatatat atatatggct gtcaatgtct    720

taggctcatg gtagcagcag aaatcgtaat aattcttttg tcacatgggt tatatccata    780

ttggagagaa ttaactcagg tgaaattaac ttgtacactg tttggtttta taatatttag    840

agggatcaca actgactgat gtccctttga agtaccattc ttcataaatc tttttttttc    900

agaatgggcc agccaactgt gacatccctt ggatcggaga tttagaacta gaaagtattc    960

tttctacatt attagggaag aaaaggagtt acttggcggt tagcaatatt ctattttgtt   1020

ttgttttgtt tttagagaca gggtctcatt atgttgacca ggctggcctc gagctcctgg   1080

gctcaagcaa tgctcccacc tcagcctccc aagtagctgg gactacaggc atgtgccact   1140

acacctggca gtgtttattc tgataaatac atttatgagc tcaaaaatgt aactctaaaa   1200

ccttatctct gaacttccat attaccatca gaaatttaga tagttgttta gttctctttt   1260

tctttgtaga acatagatat aaggcatggt ttcattgaag tcagttgtat atacatgtaa   1320

ctatcctgat gttcccaaat aaagctctgt atttctgctt agtttattgg ggaggctgct   1380

aaatgtagtg catcccaacc cattttaccc tgttctactt taaaaagagg ttggcttctt   1440

gtttggatac aaggaccaag tcactccccc aggttcctcc acagtaaggg aggcctattt   1500

aaagccgccc atggcactaa cagaaactgg actcctatga gctcagatac ataactgggc   1560

ctcacagggg tgggacagta tgtagtctag gaattggaag gatccattcc atatcaaaga   1620

actgaagcat cgtgttgccc tctcagcagc aagagtaagg tgatgcccct gtcagttata   1680

gttcctgagt tcctctgtct ttgattcttt gcctattagc cagctagctc accctcttgt   1740

ttatgccact gttttttatc ctattcatgc cttctcacag acaacttttc ttacctacag   1800

ctttggactc atccttgtct cctttctgtt tctttttcac tttcccttcc catcaccaac   1860

tttctgggtt tttttctgtt tcttcttaga gtccagtggc agggagaaac ttgtcagtcc   1920

agtctgttgc catttttcct gtttgagaaa gactcaccag cttttggctg gctcacagat   1980

tggctttcct tgggtcagga cccacccttt tccctgccag ctttggaagc ttgacagaat   2040

tcgagtgtgc agtggtggta aataaatagt aaggaacaca gagcagtcct ggaggcgtgc   2100

ctccatctgc tgatgagaaa atccagtgct gtcatccagc ccaggtccca gcggaatggg   2160

cctctctgtt cagtaggatc cccctcctgc tgagtggttc atggcatgtt tctgttcaac   2220

gcttttccat ctgtaggatt cttattctgt atttatttgt ttttttgggt ttttttattt   2280

tttgagatgg agtctcgctc tgtcgcccag gctggagtgc agtggcacga ccccagctcg   2340

ctgcagcctc tgcctcccag gacgagggag atcctcccac ctcagccttc cacgtagctg   2400

ggactacagg catgcaccac aggcatgcac caccacgcca gctaattttt gtatttttgg   2460

tagagacagg gttgcatcat gttgcccagg ctggtcttga atgcctgagc tcaagcaatc   2520

tatttgcctt ggcctcccaa agtgctggga ttacaggcat gagccaccac ggccagcctt   2580

ctcatttgtt ttttttataa ggaagctatc tcttcttccc tccccaacta gggtattctt   2640

tttccctttc gtcactttgc tcatgtactg tattccttca acttcattaa tgaatccatt   2700

tggaagcagt gaaaaaggca actcagaaag ctaagaagaa atagatagag gaatactcag   2760

agctatctga gtattttctt tagtttgtta gctctttgga gctttgaaac tggaaagacc   2820

cagggagtga tgtggagaaa gagactgagc ttgtaagaca caggagcagt gagctaaggg   2880

agatggagta gtggggacaa attctggcac attctgtcta cactctgggt agatagagga   2940

gggaggatgg agcacccatg gtgggggtat gttggtgaca gcattttccc accagccagt   3000

gtaacaagtg gctgatttgg gggaaagatg gcataaacaa atgagagaat gtgtttacta   3060

tttgatgtag atgggttatt tgcttcattt ttcaaatcag tgtatataat caagaatatt   3120

cagcatgttt gaatagactg tcagagctgg aactctttca ttaacatctc tggcaccttt   3180

agttttagcc ctgaacattt tatcttaaaa ttaaacatta ccaaatgcct tagtttattt   3240

catttattaa atttatattc ttatttgtta tttatatcag cttccaatca gaagactata   3300

caacctccta ggaataactg aagtgaagtg atggactccg atttggagag tagtaagacg   3360

tgaaaggaat acacttgtgt ttaagcacca tggccttgat gattcactgt tggggagaag   3420

aaacaagaaa agtaactggt tgtcacctat gagaccctta cgtgattgtt agttaagttt   3480

ttattcaaag cagctgtaat ttagttaata aaataattat gatctatgtt gtttgcccaa   3540

ttgagatcca gttttttgtt gttattttta atcaattagg ggcaatagta gaatggacaa   3600

tttccaagaa tgatgccttt caggtcctag ggcctctggc ctctaggtaa ccagtttaaa   3660

ttggttcagg gtgataacta cttagcactg ccctggtgat tacccagaga tatctatgaa   3720

aaccagtggc ttccatcaaa cctttgccaa ctcaggttca cagcagcttt gggcagttat   3780

ggcagtatgg cattagctga gaggtgtctg ccacttctgg gtcaatggaa taataaatta   3840

agtacaggca ggaatttggt tgggagcatc ttgtatgatc tccgtatgat gtgatattga   3900

tggagatagt ggtcctcatt cttgggggtt gccattccca cattccccct tcaacaaaca   3960

gtgtaacagg tccttcccag atttagggta cttttattga tggatatgtt ttccttttat   4020

tcacataacc ccttgaaacc ctgtcttgtc ctcctgttac ttgcttctgc tgtacaagat   4080

gtagcacctt ttctcctctt tgaacatggt ctagtgacac ggtagcacca gttgcaggaa   4140

ggagccagac ttgttctcag agcactgtgt tcacactttt cagcaaaaat agctatggtt   4200

gtaacatatg tattcccttc ctctgatttg aaggcaaaaa tctacagtgt ttcttcactt   4260

cttttctgat ctggggcatg aaaaaagcaa gattgaaatt tgaactatga gtctcctgca   4320

tggcaacaaa atgtgtgtca ccatcaggcc aacaggccag cccttgaatg gggatttatt   4380

actgttgtat ctatgttgca tgataaacat tcatcacctt cctcctgtag tcctgcctcg   4440

tactcccctt cccctatgat tgaaaagtaa acaaaaccca catttcctat cctggttaga   4500

agaaaattaa tgttctgaca gttgtgatcg cctggagtac ttttagactt ttagcattcg   4560

ttttttacct gtttgtggat gtgtgtttgt atgtgcatac gtatgagata ggcacatgca   4620

tcttctgtat ggacaaaggt ggggtaccta caggagagca aaggttaatt ttgtgctttt   4680

agtaaaaaca tttaaataca aagttcttta ttgggtggaa ttatatttga tgcaaatatt   4740

tgatcactta aaacttttaa aacttctagg taatttgcca cgctttttga ctgctcacca   4800

ataccctgta aaaatacgta attcttcctg tttgtgtaat aagatattca tatttgtagt   4860

tgcattaata atagttattt cttagtccat cagatgttcc cgtgtgcctc ttttatgcca   4920

aattgattgt catatttcat gttgggacca agtagtttgc ccatggcaaa cctaaattta   4980

tgacctgctg aggcctctca gaaaactgag catactagca agacagctct tcttgaaaaa   5040

aaaaatatgt atacacaaat atatacgtat atctatatat acgtatgtat atacacacat   5100

gtatattctt ccttgattgt gtagctgtcc aaaataataa catatataga gggagctgta   5160

ttcctttata caaatctgat ggctcctgca gcactttttc cttctgaaaa tatttacatt   5220

ttgctaacct agtttgttac tttaaaaatc agttttgatg aaaggaggga aaagcagatg   5280

gacttgaaaa agatccaagc tcctattaga aaaggtatga aaatctttat agtaaaattt   5340

tttataaact aaagttgtac cttttaatat gtagtaaact ctcatttatt tggggttcgc   5400

tcttggatct catccatcca ttgtgttctc tttaatgctg cctgcctttt gaggcattca   5460

ctgccctaga caatgccacc agagatagtg ggggaaatgc cagatgaaac caactcttgc   5520

tctcactagt tgtcagcttc tctggataag tgaccacaga agcaggagtc ctcctgcttg   5580

ggcatcattg ggccagttcc ttctctttaa atcagatttg taatggctcc caaattccat   5640

cacatcacat ttaaattgca gacagtgttt tgcacatcat gtatctgttt tgtcccataa   5700

tatgcttttt actccctgat cccagtttct gctgttgact cttccattca gttttattta   5760

ttgtgtgttc tcacagtgac accatttgtc cttttctgca acaacctttc cagctacttt   5820

tgccaaattc tatttgtctt ctccttcaaa acattctcct ttgcagttcc tcttcatctg   5880

tgtagctgct cttttgtctc ttaacttacc attcctatag tactttatgc atctctgctt   5940

agttctatta gttttttggc cttgctcttc tccttgattt taaaattcct tctatagcta   6000

gagcttttct ttctttcatt ctctcttcct gcagtgtttt gcatacatca gaagctaggt   6060

acataagtta aatgattgag agttggctgt atttagattt atcacttttt aatagggtga   6120

gcttgagagt tttctttctt tctgtttttt ttttttgttt tttttttttt tttttttttt   6180

tttttttttg actaatttca catgctctaa aaaccttcaa aggtgattat ttttctcctg   6240

gaaactccag gtccattctg tttaaatccc taagaatgtc agaattaaaa taacagggct   6300

atcccgtaat tggaaatatt tcttttttca ggatgctata gtcaatttag taagtgacca   6360

ccaaattgtt atttgcacta acaaagctca aaacacgata agtttactcc tccatctcag   6420

taataaaaat taagctgtaa tcaaccttct aggtttctct tgtcttaaaa tgggtattca   6480

aaaatgggga tctgtggtgt atgtatggaa acacatactc cttaatttac ctgttgttgg   6540

aaactggaga aatgattgtc gggcaaccgt ttatttttta ttgtatttta tttggttgag   6600

ggattttttt ataaacagtt ttacttgtgt catattttaa aattactaac tgccatcacc   6660

tgctggggtc ctttgttagg tcattttcag tgactaatag ggataatcca ggtaactttg   6720

aagagatgag cagtgagtga ccaggcagtt tttctgcctt tagctttgac agttcttaat   6780

taagatcatt gaagaccagc tttctcataa atttctcttt ttgaaaaaaa gaaagcattt   6840

gtactaagct cctctgtaag acaacatctt aaatcttaaa agtgttgtta tcatgactgg   6900

tgagagaaga aaacattttg tttttattaa atggagcatt atttacaaaa agccattgtt   6960

gagaattaga tcccacatcg tataaatatc tattaaccat tctaaataaa gagaactcca   7020

gtgttgctat gtgcaagatc ctctcttgga gcttttttgc atagcaatta aaggtgtgct   7080

atttgtcagt agccattttt ttgcagtgat ttgaagacca aagttgtttt acagctgtgt   7140

taccgttaaa ggtttttttt tttatatgta ttaaatcaat ttatcactgt ttaaagcttt   7200

gaatatctgc aatctttgcc aaggtacttt tttatttaaa aaaaaacata actttgtaaa   7260

tattaccctg taatattata tatacttaat aaaacatttt aagctatttt gttgggctat   7320

ttctattgct gctacagcag accacaagca catttctgaa aaatttaatt tattaatgta   7380

tttttaagtt gcttatattc taggtaacaa tgtaaagaat gatttaaaat attaattatg   7440

aattttttga gtataatacc caataagctt ttaattagag cagagtttta attaaaagtt   7500

ttaaatcagt cca                                                      7513


<210>  1647
<211>  89
<212>  PRT
<213>  Homo sapiens

<400>  1647


Met His Leu Leu Tyr Gly Gln Arg Trp Gly Thr Tyr Arg Arg Ala Lys 
1               5                   10                  15      


Val Asn Phe Val Leu Leu Val Lys Thr Phe Lys Tyr Lys Val Leu Tyr 
            20                  25                  30          


Trp Val Glu Leu Tyr Leu Met Gln Ile Phe Asp His Leu Lys Leu Leu 
        35                  40                  45              


Lys Leu Leu Gly Asn Leu Pro Arg Phe Leu Thr Ala His Gln Tyr Pro 
    50                  55                  60                  


Val Lys Ile Arg Asn Ser Ser Cys Leu Cys Asn Lys Ile Phe Ile Phe 
65                  70                  75                  80  


Val Val Ala Leu Ile Ile Val Ile Ser 
                85                  

<210>  1648
<211>  5272
<212>  DNA
<213>  Homo sapiens

<400>  1648
cggctctcgc gggcggggag caggcggggg agcgggcggg aagcagtggg agcgcgcgtg     60

cgcgcggccg tgcagcctgg gcagtgggtc ctgcctgtga cgcgcggcgg cggtcggtcc    120

tgcctgtaac ggcggcggcg gctgctgctc cggacacctg cggcggcggc ggcgaccccg    180

cggcgggcgc ggagatgtgg cccctggtag cggcgctgtt gctgggctcg gcgtgctgcg    240

gatcagctca gctactattt aataaaacaa aatctgtaga attcacgttt tgtaatgaca    300

ctgtcgtcat tccatgcttt gttactaata tggaggcaca aaacactact gaagtatacg    360

taaagtggaa atttaaagga agagatattt acacctttga tggagctcta aacaagtcca    420

ctgtccccac tgactttagt agtgcaaaaa ttgaagtctc acaattacta aaaggagatg    480

cctctttgaa gatggataag agtgatgctg tctcacacac aggaaactac acttgtgaag    540

taacagaatt aaccagagaa ggtgaaacga tcatcgagct aaaatatcgt gttgtttcat    600

ggttttctcc aaatgaaaat attcttattg ttattttccc aatttttgct atactcctgt    660

tctggggaca gtttggtatt aaaacactta aatatagatc cggtggtatg gatgagaaaa    720

caattgcttt acttgttgct ggactagtga tcactgtcat tgtcattgtt ggagccattc    780

ttttcgtccc aggtgaatat tcattaaaga atgctactgg ccttggttta attgtgactt    840

ctacagggat attaatatta cttcactact atgtgtttag tacagcgatt ggattaacct    900

ccttcgtcat tgccatattg gttattcagg tgatagccta tatcctcgct gtggttggac    960

tgagtctctg tattgcggcg tgtataccaa tgcatggccc tcttctgatt tcaggtttga   1020

gtatcttagc tctagcacaa ttacttggac tagtttatat gaaatttgtg gaataactga   1080

agtgaagtga tggactccga tttggagagt agtaagacgt gaaaggaata cacttgtgtt   1140

taagcaccat ggccttgatg attcactgtt ggggagaaga aacaagaaaa gtaactggtt   1200

gtcacctatg agacccttac gtgattgtta gttaagtttt tattcaaagc agctgtaatt   1260

tagttaataa aataattatg atctatgttg tttgcccaat tgagatccag ttttttgttg   1320

ttatttttaa tcaattaggg gcaatagtag aatggacaat ttccaagaat gatgcctttc   1380

aggtcctagg gcctctggcc tctaggtaac cagtttaaat tggttcaggg tgataactac   1440

ttagcactgc cctggtgatt acccagagat atctatgaaa accagtggct tccatcaaac   1500

ctttgccaac tcaggttcac agcagctttg ggcagttatg gcagtatggc attagctgag   1560

aggtgtctgc cacttctggg tcaatggaat aataaattaa gtacaggcag gaatttggtt   1620

gggagcatct tgtatgatct ccgtatgatg tgatattgat ggagatagtg gtcctcattc   1680

ttgggggttg ccattcccac attccccctt caacaaacag tgtaacaggt ccttcccaga   1740

tttagggtac ttttattgat ggatatgttt tccttttatt cacataaccc cttgaaaccc   1800

tgtcttgtcc tcctgttact tgcttctgct gtacaagatg tagcaccttt tctcctcttt   1860

gaacatggtc tagtgacacg gtagcaccag ttgcaggaag gagccagact tgttctcaga   1920

gcactgtgtt cacacttttc agcaaaaata gctatggttg taacatatgt attcccttcc   1980

tctgatttga aggcaaaaat ctacagtgtt tcttcacttc ttttctgatc tggggcatga   2040

aaaaagcaag attgaaattt gaactatgag tctcctgcat ggcaacaaaa tgtgtgtcac   2100

catcaggcca acaggccagc ccttgaatgg ggatttatta ctgttgtatc tatgttgcat   2160

gataaacatt catcaccttc ctcctgtagt cctgcctcgt actccccttc ccctatgatt   2220

gaaaagtaaa caaaacccac atttcctatc ctggttagaa gaaaattaat gttctgacag   2280

ttgtgatcgc ctggagtact tttagacttt tagcattcgt tttttacctg tttgtggatg   2340

tgtgtttgta tgtgcatacg tatgagatag gcacatgcat cttctgtatg gacaaaggtg   2400

gggtacctac aggagagcaa aggttaattt tgtgctttta gtaaaaacat ttaaatacaa   2460

agttctttat tgggtggaat tatatttgat gcaaatattt gatcacttaa aacttttaaa   2520

acttctaggt aatttgccac gctttttgac tgctcaccaa taccctgtaa aaatacgtaa   2580

ttcttcctgt ttgtgtaata agatattcat atttgtagtt gcattaataa tagttatttc   2640

ttagtccatc agatgttccc gtgtgcctct tttatgccaa attgattgtc atatttcatg   2700

ttgggaccaa gtagtttgcc catggcaaac ctaaatttat gacctgctga ggcctctcag   2760

aaaactgagc atactagcaa gacagctctt cttgaaaaaa aaaatatgta tacacaaata   2820

tatacgtata tctatatata cgtatgtata tacacacatg tatattcttc cttgattgtg   2880

tagctgtcca aaataataac atatatagag ggagctgtat tcctttatac aaatctgatg   2940

gctcctgcag cactttttcc ttctgaaaat atttacattt tgctaaccta gtttgttact   3000

ttaaaaatca gttttgatga aaggagggaa aagcagatgg acttgaaaaa gatccaagct   3060

cctattagaa aaggtatgaa aatctttata gtaaaatttt ttataaacta aagttgtacc   3120

ttttaatatg tagtaaactc tcatttattt ggggttcgct cttggatctc atccatccat   3180

tgtgttctct ttaatgctgc ctgccttttg aggcattcac tgccctagac aatgccacca   3240

gagatagtgg gggaaatgcc agatgaaacc aactcttgct ctcactagtt gtcagcttct   3300

ctggataagt gaccacagaa gcaggagtcc tcctgcttgg gcatcattgg gccagttcct   3360

tctctttaaa tcagatttgt aatggctccc aaattccatc acatcacatt taaattgcag   3420

acagtgtttt gcacatcatg tatctgtttt gtcccataat atgcttttta ctccctgatc   3480

ccagtttctg ctgttgactc ttccattcag ttttatttat tgtgtgttct cacagtgaca   3540

ccatttgtcc ttttctgcaa caacctttcc agctactttt gccaaattct atttgtcttc   3600

tccttcaaaa cattctcctt tgcagttcct cttcatctgt gtagctgctc ttttgtctct   3660

taacttacca ttcctatagt actttatgca tctctgctta gttctattag ttttttggcc   3720

ttgctcttct ccttgatttt aaaattcctt ctatagctag agcttttctt tctttcattc   3780

tctcttcctg cagtgttttg catacatcag aagctaggta cataagttaa atgattgaga   3840

gttggctgta tttagattta tcacttttta atagggtgag cttgagagtt ttctttcttt   3900

ctgttttttt tttttgtttt tttttttttt tttttttttt ttttttttga ctaatttcac   3960

atgctctaaa aaccttcaaa ggtgattatt tttctcctgg aaactccagg tccattctgt   4020

ttaaatccct aagaatgtca gaattaaaat aacagggcta tcccgtaatt ggaaatattt   4080

cttttttcag gatgctatag tcaatttagt aagtgaccac caaattgtta tttgcactaa   4140

caaagctcaa aacacgataa gtttactcct ccatctcagt aataaaaatt aagctgtaat   4200

caaccttcta ggtttctctt gtcttaaaat gggtattcaa aaatggggat ctgtggtgta   4260

tgtatggaaa cacatactcc ttaatttacc tgttgttgga aactggagaa atgattgtcg   4320

ggcaaccgtt tattttttat tgtattttat ttggttgagg gattttttta taaacagttt   4380

tacttgtgtc atattttaaa attactaact gccatcacct gctggggtcc tttgttaggt   4440

cattttcagt gactaatagg gataatccag gtaactttga agagatgagc agtgagtgac   4500

caggcagttt ttctgccttt agctttgaca gttcttaatt aagatcattg aagaccagct   4560

ttctcataaa tttctctttt tgaaaaaaag aaagcatttg tactaagctc ctctgtaaga   4620

caacatctta aatcttaaaa gtgttgttat catgactggt gagagaagaa aacattttgt   4680

ttttattaaa tggagcatta tttacaaaaa gccattgttg agaattagat cccacatcgt   4740

ataaatatct attaaccatt ctaaataaag agaactccag tgttgctatg tgcaagatcc   4800

tctcttggag cttttttgca tagcaattaa aggtgtgcta tttgtcagta gccatttttt   4860

tgcagtgatt tgaagaccaa agttgtttta cagctgtgtt accgttaaag gttttttttt   4920

ttatatgtat taaatcaatt tatcactgtt taaagctttg aatatctgca atctttgcca   4980

aggtactttt ttatttaaaa aaaaacataa ctttgtaaat attaccctgt aatattatat   5040

atacttaata aaacatttta agctattttg ttgggctatt tctattgctg ctacagcaga   5100

ccacaagcac atttctgaaa aatttaattt attaatgtat ttttaagttg cttatattct   5160

aggtaacaat gtaaagaatg atttaaaata ttaattatga attttttgag tataataccc   5220

aataagcttt taattagagc agagttttaa ttaaaagttt taaatcagtc ca           5272


<210>  1649
<211>  293
<212>  PRT
<213>  Homo sapiens

<400>  1649


Met Trp Pro Leu Val Ala Ala Leu Leu Leu Gly Ser Ala Cys Cys Gly 
1               5                   10                  15      


Ser Ala Gln Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe 
            20                  25                  30          


Cys Asn Asp Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala 
        35                  40                  45              


Gln Asn Thr Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp 
    50                  55                  60                  


Ile Tyr Thr Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp 
65                  70                  75                  80  


Phe Ser Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala 
                85                  90                  95      


Ser Leu Lys Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr 
            100                 105                 110         


Thr Cys Glu Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu 
        115                 120                 125             


Leu Lys Tyr Arg Val Val Ser Trp Phe Ser Pro Asn Glu Asn Ile Leu 
    130                 135                 140                 


Ile Val Ile Phe Pro Ile Phe Ala Ile Leu Leu Phe Trp Gly Gln Phe 
145                 150                 155                 160 


Gly Ile Lys Thr Leu Lys Tyr Arg Ser Gly Gly Met Asp Glu Lys Thr 
                165                 170                 175     


Ile Ala Leu Leu Val Ala Gly Leu Val Ile Thr Val Ile Val Ile Val 
            180                 185                 190         


Gly Ala Ile Leu Phe Val Pro Gly Glu Tyr Ser Leu Lys Asn Ala Thr 
        195                 200                 205             


Gly Leu Gly Leu Ile Val Thr Ser Thr Gly Ile Leu Ile Leu Leu His 
    210                 215                 220                 


Tyr Tyr Val Phe Ser Thr Ala Ile Gly Leu Thr Ser Phe Val Ile Ala 
225                 230                 235                 240 


Ile Leu Val Ile Gln Val Ile Ala Tyr Ile Leu Ala Val Val Gly Leu 
                245                 250                 255     


Ser Leu Cys Ile Ala Ala Cys Ile Pro Met His Gly Pro Leu Leu Ile 
            260                 265                 270         


Ser Gly Leu Ser Ile Leu Ala Leu Ala Gln Leu Leu Gly Leu Val Tyr 
        275                 280                 285             


Met Lys Phe Val Glu 
    290             

<210>  1650
<211>  5304
<212>  DNA
<213>  Homo sapiens

<400>  1650
cggctctcgc gggcggggag caggcggggg agcgggcggg aagcagtggg agcgcgcgtg     60

cgcgcggccg tgcagcctgg gcagtgggtc ctgcctgtga cgcgcggcgg cggtcggtcc    120

tgcctgtaac ggcggcggcg gctgctgctc cggacacctg cggcggcggc ggcgaccccg    180

cggcgggcgc ggagatgtgg cccctggtag cggcgctgtt gctgggctcg gcgtgctgcg    240

gatcagctca gctactattt aataaaacaa aatctgtaga attcacgttt tgtaatgaca    300

ctgtcgtcat tccatgcttt gttactaata tggaggcaca aaacactact gaagtatacg    360

taaagtggaa atttaaagga agagatattt acacctttga tggagctcta aacaagtcca    420

ctgtccccac tgactttagt agtgcaaaaa ttgaagtctc acaattacta aaaggagatg    480

cctctttgaa gatggataag agtgatgctg tctcacacac aggaaactac acttgtgaag    540

taacagaatt aaccagagaa ggtgaaacga tcatcgagct aaaatatcgt gttgtttcat    600

ggttttctcc aaatgaaaat attcttattg ttattttccc aatttttgct atactcctgt    660

tctggggaca gtttggtatt aaaacactta aatatagatc cggtggtatg gatgagaaaa    720

caattgcttt acttgttgct ggactagtga tcactgtcat tgtcattgtt ggagccattc    780

ttttcgtccc aggtgaatat tcattaaaga atgctactgg ccttggttta attgtgactt    840

ctacagggat attaatatta cttcactact atgtgtttag tacagcgatt ggattaacct    900

ccttcgtcat tgccatattg gttattcagg tgatagccta tatcctcgct gtggttggac    960

tgagtctctg tattgcggcg tgtataccaa tgcatggccc tcttctgatt tcaggtttga   1020

gtatcttagc tctagcacaa ttacttggac tagtttatat gaaatttgtg gcttccaatc   1080

agaagactat acaacctcct aggaataact gaagtgaagt gatggactcc gatttggaga   1140

gtagtaagac gtgaaaggaa tacacttgtg tttaagcacc atggccttga tgattcactg   1200

ttggggagaa gaaacaagaa aagtaactgg ttgtcaccta tgagaccctt acgtgattgt   1260

tagttaagtt tttattcaaa gcagctgtaa tttagttaat aaaataatta tgatctatgt   1320

tgtttgccca attgagatcc agttttttgt tgttattttt aatcaattag gggcaatagt   1380

agaatggaca atttccaaga atgatgcctt tcaggtccta gggcctctgg cctctaggta   1440

accagtttaa attggttcag ggtgataact acttagcact gccctggtga ttacccagag   1500

atatctatga aaaccagtgg cttccatcaa acctttgcca actcaggttc acagcagctt   1560

tgggcagtta tggcagtatg gcattagctg agaggtgtct gccacttctg ggtcaatgga   1620

ataataaatt aagtacaggc aggaatttgg ttgggagcat cttgtatgat ctccgtatga   1680

tgtgatattg atggagatag tggtcctcat tcttgggggt tgccattccc acattccccc   1740

ttcaacaaac agtgtaacag gtccttccca gatttagggt acttttattg atggatatgt   1800

tttcctttta ttcacataac cccttgaaac cctgtcttgt cctcctgtta cttgcttctg   1860

ctgtacaaga tgtagcacct tttctcctct ttgaacatgg tctagtgaca cggtagcacc   1920

agttgcagga aggagccaga cttgttctca gagcactgtg ttcacacttt tcagcaaaaa   1980

tagctatggt tgtaacatat gtattccctt cctctgattt gaaggcaaaa atctacagtg   2040

tttcttcact tcttttctga tctggggcat gaaaaaagca agattgaaat ttgaactatg   2100

agtctcctgc atggcaacaa aatgtgtgtc accatcaggc caacaggcca gcccttgaat   2160

ggggatttat tactgttgta tctatgttgc atgataaaca ttcatcacct tcctcctgta   2220

gtcctgcctc gtactcccct tcccctatga ttgaaaagta aacaaaaccc acatttccta   2280

tcctggttag aagaaaatta atgttctgac agttgtgatc gcctggagta cttttagact   2340

tttagcattc gttttttacc tgtttgtgga tgtgtgtttg tatgtgcata cgtatgagat   2400

aggcacatgc atcttctgta tggacaaagg tggggtacct acaggagagc aaaggttaat   2460

tttgtgcttt tagtaaaaac atttaaatac aaagttcttt attgggtgga attatatttg   2520

atgcaaatat ttgatcactt aaaactttta aaacttctag gtaatttgcc acgctttttg   2580

actgctcacc aataccctgt aaaaatacgt aattcttcct gtttgtgtaa taagatattc   2640

atatttgtag ttgcattaat aatagttatt tcttagtcca tcagatgttc ccgtgtgcct   2700

cttttatgcc aaattgattg tcatatttca tgttgggacc aagtagtttg cccatggcaa   2760

acctaaattt atgacctgct gaggcctctc agaaaactga gcatactagc aagacagctc   2820

ttcttgaaaa aaaaaatatg tatacacaaa tatatacgta tatctatata tacgtatgta   2880

tatacacaca tgtatattct tccttgattg tgtagctgtc caaaataata acatatatag   2940

agggagctgt attcctttat acaaatctga tggctcctgc agcacttttt ccttctgaaa   3000

atatttacat tttgctaacc tagtttgtta ctttaaaaat cagttttgat gaaaggaggg   3060

aaaagcagat ggacttgaaa aagatccaag ctcctattag aaaaggtatg aaaatcttta   3120

tagtaaaatt ttttataaac taaagttgta ccttttaata tgtagtaaac tctcatttat   3180

ttggggttcg ctcttggatc tcatccatcc attgtgttct ctttaatgct gcctgccttt   3240

tgaggcattc actgccctag acaatgccac cagagatagt gggggaaatg ccagatgaaa   3300

ccaactcttg ctctcactag ttgtcagctt ctctggataa gtgaccacag aagcaggagt   3360

cctcctgctt gggcatcatt gggccagttc cttctcttta aatcagattt gtaatggctc   3420

ccaaattcca tcacatcaca tttaaattgc agacagtgtt ttgcacatca tgtatctgtt   3480

ttgtcccata atatgctttt tactccctga tcccagtttc tgctgttgac tcttccattc   3540

agttttattt attgtgtgtt ctcacagtga caccatttgt ccttttctgc aacaaccttt   3600

ccagctactt ttgccaaatt ctatttgtct tctccttcaa aacattctcc tttgcagttc   3660

ctcttcatct gtgtagctgc tcttttgtct cttaacttac cattcctata gtactttatg   3720

catctctgct tagttctatt agttttttgg ccttgctctt ctccttgatt ttaaaattcc   3780

ttctatagct agagcttttc tttctttcat tctctcttcc tgcagtgttt tgcatacatc   3840

agaagctagg tacataagtt aaatgattga gagttggctg tatttagatt tatcactttt   3900

taatagggtg agcttgagag ttttctttct ttctgttttt tttttttgtt tttttttttt   3960

tttttttttt tttttttttt gactaatttc acatgctcta aaaaccttca aaggtgatta   4020

tttttctcct ggaaactcca ggtccattct gtttaaatcc ctaagaatgt cagaattaaa   4080

ataacagggc tatcccgtaa ttggaaatat ttcttttttc aggatgctat agtcaattta   4140

gtaagtgacc accaaattgt tatttgcact aacaaagctc aaaacacgat aagtttactc   4200

ctccatctca gtaataaaaa ttaagctgta atcaaccttc taggtttctc ttgtcttaaa   4260

atgggtattc aaaaatgggg atctgtggtg tatgtatgga aacacatact ccttaattta   4320

cctgttgttg gaaactggag aaatgattgt cgggcaaccg tttatttttt attgtatttt   4380

atttggttga gggatttttt tataaacagt tttacttgtg tcatatttta aaattactaa   4440

ctgccatcac ctgctggggt cctttgttag gtcattttca gtgactaata gggataatcc   4500

aggtaacttt gaagagatga gcagtgagtg accaggcagt ttttctgcct ttagctttga   4560

cagttcttaa ttaagatcat tgaagaccag ctttctcata aatttctctt tttgaaaaaa   4620

agaaagcatt tgtactaagc tcctctgtaa gacaacatct taaatcttaa aagtgttgtt   4680

atcatgactg gtgagagaag aaaacatttt gtttttatta aatggagcat tatttacaaa   4740

aagccattgt tgagaattag atcccacatc gtataaatat ctattaacca ttctaaataa   4800

agagaactcc agtgttgcta tgtgcaagat cctctcttgg agcttttttg catagcaatt   4860

aaaggtgtgc tatttgtcag tagccatttt tttgcagtga tttgaagacc aaagttgttt   4920

tacagctgtg ttaccgttaa aggttttttt ttttatatgt attaaatcaa tttatcactg   4980

tttaaagctt tgaatatctg caatctttgc caaggtactt ttttatttaa aaaaaaacat   5040

aactttgtaa atattaccct gtaatattat atatacttaa taaaacattt taagctattt   5100

tgttgggcta tttctattgc tgctacagca gaccacaagc acatttctga aaaatttaat   5160

ttattaatgt atttttaagt tgcttatatt ctaggtaaca atgtaaagaa tgatttaaaa   5220

tattaattat gaattttttg agtataatac ccaataagct tttaattaga gcagagtttt   5280

aattaaaagt tttaaatcag tcca                                          5304


<210>  1651
<211>  305
<212>  PRT
<213>  Homo sapiens

<400>  1651


Met Trp Pro Leu Val Ala Ala Leu Leu Leu Gly Ser Ala Cys Cys Gly 
1               5                   10                  15      


Ser Ala Gln Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe 
            20                  25                  30          


Cys Asn Asp Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala 
        35                  40                  45              


Gln Asn Thr Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp 
    50                  55                  60                  


Ile Tyr Thr Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp 
65                  70                  75                  80  


Phe Ser Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala 
                85                  90                  95      


Ser Leu Lys Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr 
            100                 105                 110         


Thr Cys Glu Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu 
        115                 120                 125             


Leu Lys Tyr Arg Val Val Ser Trp Phe Ser Pro Asn Glu Asn Ile Leu 
    130                 135                 140                 


Ile Val Ile Phe Pro Ile Phe Ala Ile Leu Leu Phe Trp Gly Gln Phe 
145                 150                 155                 160 


Gly Ile Lys Thr Leu Lys Tyr Arg Ser Gly Gly Met Asp Glu Lys Thr 
                165                 170                 175     


Ile Ala Leu Leu Val Ala Gly Leu Val Ile Thr Val Ile Val Ile Val 
            180                 185                 190         


Gly Ala Ile Leu Phe Val Pro Gly Glu Tyr Ser Leu Lys Asn Ala Thr 
        195                 200                 205             


Gly Leu Gly Leu Ile Val Thr Ser Thr Gly Ile Leu Ile Leu Leu His 
    210                 215                 220                 


Tyr Tyr Val Phe Ser Thr Ala Ile Gly Leu Thr Ser Phe Val Ile Ala 
225                 230                 235                 240 


Ile Leu Val Ile Gln Val Ile Ala Tyr Ile Leu Ala Val Val Gly Leu 
                245                 250                 255     


Ser Leu Cys Ile Ala Ala Cys Ile Pro Met His Gly Pro Leu Leu Ile 
            260                 265                 270         


Ser Gly Leu Ser Ile Leu Ala Leu Ala Gln Leu Leu Gly Leu Val Tyr 
        275                 280                 285             


Met Lys Phe Val Ala Ser Asn Gln Lys Thr Ile Gln Pro Pro Arg Asn 
    290                 295                 300                 


Asn 
305 

<210>  1652
<211>  5329
<212>  DNA
<213>  Homo sapiens

<400>  1652
cggctctcgc gggcggggag caggcggggg agcgggcggg aagcagtggg agcgcgcgtg     60

cgcgcggccg tgcagcctgg gcagtgggtc ctgcctgtga cgcgcggcgg cggtcggtcc    120

tgcctgtaac ggcggcggcg gctgctgctc cggacacctg cggcggcggc ggcgaccccg    180

cggcgggcgc ggagatgtgg cccctggtag cggcgctgtt gctgggctcg gcgtgctgcg    240

gatcagctca gctactattt aataaaacaa aatctgtaga attcacgttt tgtaatgaca    300

ctgtcgtcat tccatgcttt gttactaata tggaggcaca aaacactact gaagtatacg    360

taaagtggaa atttaaagga agagatattt acacctttga tggagctcta aacaagtcca    420

ctgtccccac tgactttagt agtgcaaaaa ttgaagtctc acaattacta aaaggagatg    480

cctctttgaa gatggataag agtgatgctg tctcacacac aggaaactac acttgtgaag    540

taacagaatt aaccagagaa ggtgaaacga tcatcgagct aaaatatcgt gttgtttcat    600

ggttttctcc aaatgaaaat attcttattg ttattttccc aatttttgct atactcctgt    660

tctggggaca gtttggtatt aaaacactta aatatagatc cggtggtatg gatgagaaaa    720

caattgcttt acttgttgct ggactagtga tcactgtcat tgtcattgtt ggagccattc    780

ttttcgtccc aggtgaatat tcattaaaga atgctactgg ccttggttta attgtgactt    840

ctacagggat attaatatta cttcactact atgtgtttag tacagcgatt ggattaacct    900

ccttcgtcat tgccatattg gttattcagg tgatagccta tatcctcgct gtggttggac    960

tgagtctctg tattgcggcg tgtataccaa tgcatggccc tcttctgatt tcaggtttga   1020

gtatcttagc tctagcacaa ttacttggac tagtttatat gaaatttgtg gcttccaatc   1080

agaagactat acaacctcct aggaaagctg tagaggaacc ccttaatgaa taactgaagt   1140

gaagtgatgg actccgattt ggagagtagt aagacgtgaa aggaatacac ttgtgtttaa   1200

gcaccatggc cttgatgatt cactgttggg gagaagaaac aagaaaagta actggttgtc   1260

acctatgaga cccttacgtg attgttagtt aagtttttat tcaaagcagc tgtaatttag   1320

ttaataaaat aattatgatc tatgttgttt gcccaattga gatccagttt tttgttgtta   1380

tttttaatca attaggggca atagtagaat ggacaatttc caagaatgat gcctttcagg   1440

tcctagggcc tctggcctct aggtaaccag tttaaattgg ttcagggtga taactactta   1500

gcactgccct ggtgattacc cagagatatc tatgaaaacc agtggcttcc atcaaacctt   1560

tgccaactca ggttcacagc agctttgggc agttatggca gtatggcatt agctgagagg   1620

tgtctgccac ttctgggtca atggaataat aaattaagta caggcaggaa tttggttggg   1680

agcatcttgt atgatctccg tatgatgtga tattgatgga gatagtggtc ctcattcttg   1740

ggggttgcca ttcccacatt cccccttcaa caaacagtgt aacaggtcct tcccagattt   1800

agggtacttt tattgatgga tatgttttcc ttttattcac ataacccctt gaaaccctgt   1860

cttgtcctcc tgttacttgc ttctgctgta caagatgtag caccttttct cctctttgaa   1920

catggtctag tgacacggta gcaccagttg caggaaggag ccagacttgt tctcagagca   1980

ctgtgttcac acttttcagc aaaaatagct atggttgtaa catatgtatt cccttcctct   2040

gatttgaagg caaaaatcta cagtgtttct tcacttcttt tctgatctgg ggcatgaaaa   2100

aagcaagatt gaaatttgaa ctatgagtct cctgcatggc aacaaaatgt gtgtcaccat   2160

caggccaaca ggccagccct tgaatgggga tttattactg ttgtatctat gttgcatgat   2220

aaacattcat caccttcctc ctgtagtcct gcctcgtact ccccttcccc tatgattgaa   2280

aagtaaacaa aacccacatt tcctatcctg gttagaagaa aattaatgtt ctgacagttg   2340

tgatcgcctg gagtactttt agacttttag cattcgtttt ttacctgttt gtggatgtgt   2400

gtttgtatgt gcatacgtat gagataggca catgcatctt ctgtatggac aaaggtgggg   2460

tacctacagg agagcaaagg ttaattttgt gcttttagta aaaacattta aatacaaagt   2520

tctttattgg gtggaattat atttgatgca aatatttgat cacttaaaac ttttaaaact   2580

tctaggtaat ttgccacgct ttttgactgc tcaccaatac cctgtaaaaa tacgtaattc   2640

ttcctgtttg tgtaataaga tattcatatt tgtagttgca ttaataatag ttatttctta   2700

gtccatcaga tgttcccgtg tgcctctttt atgccaaatt gattgtcata tttcatgttg   2760

ggaccaagta gtttgcccat ggcaaaccta aatttatgac ctgctgaggc ctctcagaaa   2820

actgagcata ctagcaagac agctcttctt gaaaaaaaaa atatgtatac acaaatatat   2880

acgtatatct atatatacgt atgtatatac acacatgtat attcttcctt gattgtgtag   2940

ctgtccaaaa taataacata tatagaggga gctgtattcc tttatacaaa tctgatggct   3000

cctgcagcac tttttccttc tgaaaatatt tacattttgc taacctagtt tgttacttta   3060

aaaatcagtt ttgatgaaag gagggaaaag cagatggact tgaaaaagat ccaagctcct   3120

attagaaaag gtatgaaaat ctttatagta aaatttttta taaactaaag ttgtaccttt   3180

taatatgtag taaactctca tttatttggg gttcgctctt ggatctcatc catccattgt   3240

gttctcttta atgctgcctg ccttttgagg cattcactgc cctagacaat gccaccagag   3300

atagtggggg aaatgccaga tgaaaccaac tcttgctctc actagttgtc agcttctctg   3360

gataagtgac cacagaagca ggagtcctcc tgcttgggca tcattgggcc agttccttct   3420

ctttaaatca gatttgtaat ggctcccaaa ttccatcaca tcacatttaa attgcagaca   3480

gtgttttgca catcatgtat ctgttttgtc ccataatatg ctttttactc cctgatccca   3540

gtttctgctg ttgactcttc cattcagttt tatttattgt gtgttctcac agtgacacca   3600

tttgtccttt tctgcaacaa cctttccagc tacttttgcc aaattctatt tgtcttctcc   3660

ttcaaaacat tctcctttgc agttcctctt catctgtgta gctgctcttt tgtctcttaa   3720

cttaccattc ctatagtact ttatgcatct ctgcttagtt ctattagttt tttggccttg   3780

ctcttctcct tgattttaaa attccttcta tagctagagc ttttctttct ttcattctct   3840

cttcctgcag tgttttgcat acatcagaag ctaggtacat aagttaaatg attgagagtt   3900

ggctgtattt agatttatca ctttttaata gggtgagctt gagagttttc tttctttctg   3960

tttttttttt ttgttttttt tttttttttt tttttttttt tttttgacta atttcacatg   4020

ctctaaaaac cttcaaaggt gattattttt ctcctggaaa ctccaggtcc attctgttta   4080

aatccctaag aatgtcagaa ttaaaataac agggctatcc cgtaattgga aatatttctt   4140

ttttcaggat gctatagtca atttagtaag tgaccaccaa attgttattt gcactaacaa   4200

agctcaaaac acgataagtt tactcctcca tctcagtaat aaaaattaag ctgtaatcaa   4260

ccttctaggt ttctcttgtc ttaaaatggg tattcaaaaa tggggatctg tggtgtatgt   4320

atggaaacac atactcctta atttacctgt tgttggaaac tggagaaatg attgtcgggc   4380

aaccgtttat tttttattgt attttatttg gttgagggat ttttttataa acagttttac   4440

ttgtgtcata ttttaaaatt actaactgcc atcacctgct ggggtccttt gttaggtcat   4500

tttcagtgac taatagggat aatccaggta actttgaaga gatgagcagt gagtgaccag   4560

gcagtttttc tgcctttagc tttgacagtt cttaattaag atcattgaag accagctttc   4620

tcataaattt ctctttttga aaaaaagaaa gcatttgtac taagctcctc tgtaagacaa   4680

catcttaaat cttaaaagtg ttgttatcat gactggtgag agaagaaaac attttgtttt   4740

tattaaatgg agcattattt acaaaaagcc attgttgaga attagatccc acatcgtata   4800

aatatctatt aaccattcta aataaagaga actccagtgt tgctatgtgc aagatcctct   4860

cttggagctt ttttgcatag caattaaagg tgtgctattt gtcagtagcc atttttttgc   4920

agtgatttga agaccaaagt tgttttacag ctgtgttacc gttaaaggtt ttttttttta   4980

tatgtattaa atcaatttat cactgtttaa agctttgaat atctgcaatc tttgccaagg   5040

tactttttta tttaaaaaaa aacataactt tgtaaatatt accctgtaat attatatata   5100

cttaataaaa cattttaagc tattttgttg ggctatttct attgctgcta cagcagacca   5160

caagcacatt tctgaaaaat ttaatttatt aatgtatttt taagttgctt atattctagg   5220

taacaatgta aagaatgatt taaaatatta attatgaatt ttttgagtat aatacccaat   5280

aagcttttaa ttagagcaga gttttaatta aaagttttaa atcagtcca               5329


<210>  1653
<211>  312
<212>  PRT
<213>  Homo sapiens

<400>  1653


Met Trp Pro Leu Val Ala Ala Leu Leu Leu Gly Ser Ala Cys Cys Gly 
1               5                   10                  15      


Ser Ala Gln Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe 
            20                  25                  30          


Cys Asn Asp Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala 
        35                  40                  45              


Gln Asn Thr Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp 
    50                  55                  60                  


Ile Tyr Thr Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp 
65                  70                  75                  80  


Phe Ser Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala 
                85                  90                  95      


Ser Leu Lys Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr 
            100                 105                 110         


Thr Cys Glu Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu 
        115                 120                 125             


Leu Lys Tyr Arg Val Val Ser Trp Phe Ser Pro Asn Glu Asn Ile Leu 
    130                 135                 140                 


Ile Val Ile Phe Pro Ile Phe Ala Ile Leu Leu Phe Trp Gly Gln Phe 
145                 150                 155                 160 


Gly Ile Lys Thr Leu Lys Tyr Arg Ser Gly Gly Met Asp Glu Lys Thr 
                165                 170                 175     


Ile Ala Leu Leu Val Ala Gly Leu Val Ile Thr Val Ile Val Ile Val 
            180                 185                 190         


Gly Ala Ile Leu Phe Val Pro Gly Glu Tyr Ser Leu Lys Asn Ala Thr 
        195                 200                 205             


Gly Leu Gly Leu Ile Val Thr Ser Thr Gly Ile Leu Ile Leu Leu His 
    210                 215                 220                 


Tyr Tyr Val Phe Ser Thr Ala Ile Gly Leu Thr Ser Phe Val Ile Ala 
225                 230                 235                 240 


Ile Leu Val Ile Gln Val Ile Ala Tyr Ile Leu Ala Val Val Gly Leu 
                245                 250                 255     


Ser Leu Cys Ile Ala Ala Cys Ile Pro Met His Gly Pro Leu Leu Ile 
            260                 265                 270         


Ser Gly Leu Ser Ile Leu Ala Leu Ala Gln Leu Leu Gly Leu Val Tyr 
        275                 280                 285             


Met Lys Phe Val Ala Ser Asn Gln Lys Thr Ile Gln Pro Pro Arg Lys 
    290                 295                 300                 


Ala Val Glu Glu Pro Leu Asn Glu 
305                 310         

<210>  1654
<211>  5409
<212>  DNA
<213>  Homo sapiens

<400>  1654
cggctctcgc gggcggggag caggcggggg agcgggcggg aagcagtggg agcgcgcgtg     60

cgcgcggccg tgcagcctgg gcagtgggtc ctgcctgtga cgcgcggcgg cggtcggtcc    120

tgcctgtaac ggcggcggcg gctgctgctc cggacacctg cggcggcggc ggcgaccccg    180

cggcgggcgc ggagatgtgg cccctggtag cggcgctgtt gctgggctcg gcgtgctgcg    240

gatcagctca gctactattt aataaaacaa aatctgtaga attcacgttt tgtaatgaca    300

ctgtcgtcat tccatgcttt gttactaata tggaggcaca aaacactact gaagtatacg    360

taaagtggaa atttaaagga agagatattt acacctttga tggagctcta aacaagtcca    420

ctgtccccac tgactttagt agtgcaaaaa ttgaagtctc acaattacta aaaggagatg    480

cctctttgaa gatggataag agtgatgctg tctcacacac aggaaactac acttgtgaag    540

taacagaatt aaccagagaa ggtgaaacga tcatcgagct aaaatatcgt gttgtttcat    600

ggttttctcc aaatgaaaat attcttattg ttattttccc aatttttgct atactcctgt    660

tctggggaca gtttggtatt aaaacactta aatatagatc cggtggtatg gatgagaaaa    720

caattgcttt acttgttgct ggactagtga tcactgtcat tgtcattgtt ggagccattc    780

ttttcgtccc aggtgaatat tcattaaaga atgctactgg ccttggttta attgtgactt    840

ctacagggat attaatatta cttcactact atgtgtttag tacagcgatt ggattaacct    900

ccttcgtcat tgccatattg gttattcagg tgatagccta tatcctcgct gtggttggac    960

tgagtctctg tattgcggcg tgtataccaa tgcatggccc tcttctgatt tcaggtttga   1020

gtatcttagc tctagcacaa ttacttggac tagtttatat gaaatttgtg gggttcagag   1080

ggacacctac agtcagttga aaggcaagaa gagacaagct tccaatcaga agactataca   1140

acctcctagg aaagctgtag aggaacccct taatgcattc aaagaatcaa aaggaatgat   1200

gaatgatgaa taactgaagt gaagtgatgg actccgattt ggagagtagt aagacgtgaa   1260

aggaatacac ttgtgtttaa gcaccatggc cttgatgatt cactgttggg gagaagaaac   1320

aagaaaagta actggttgtc acctatgaga cccttacgtg attgttagtt aagtttttat   1380

tcaaagcagc tgtaatttag ttaataaaat aattatgatc tatgttgttt gcccaattga   1440

gatccagttt tttgttgtta tttttaatca attaggggca atagtagaat ggacaatttc   1500

caagaatgat gcctttcagg tcctagggcc tctggcctct aggtaaccag tttaaattgg   1560

ttcagggtga taactactta gcactgccct ggtgattacc cagagatatc tatgaaaacc   1620

agtggcttcc atcaaacctt tgccaactca ggttcacagc agctttgggc agttatggca   1680

gtatggcatt agctgagagg tgtctgccac ttctgggtca atggaataat aaattaagta   1740

caggcaggaa tttggttggg agcatcttgt atgatctccg tatgatgtga tattgatgga   1800

gatagtggtc ctcattcttg ggggttgcca ttcccacatt cccccttcaa caaacagtgt   1860

aacaggtcct tcccagattt agggtacttt tattgatgga tatgttttcc ttttattcac   1920

ataacccctt gaaaccctgt cttgtcctcc tgttacttgc ttctgctgta caagatgtag   1980

caccttttct cctctttgaa catggtctag tgacacggta gcaccagttg caggaaggag   2040

ccagacttgt tctcagagca ctgtgttcac acttttcagc aaaaatagct atggttgtaa   2100

catatgtatt cccttcctct gatttgaagg caaaaatcta cagtgtttct tcacttcttt   2160

tctgatctgg ggcatgaaaa aagcaagatt gaaatttgaa ctatgagtct cctgcatggc   2220

aacaaaatgt gtgtcaccat caggccaaca ggccagccct tgaatgggga tttattactg   2280

ttgtatctat gttgcatgat aaacattcat caccttcctc ctgtagtcct gcctcgtact   2340

ccccttcccc tatgattgaa aagtaaacaa aacccacatt tcctatcctg gttagaagaa   2400

aattaatgtt ctgacagttg tgatcgcctg gagtactttt agacttttag cattcgtttt   2460

ttacctgttt gtggatgtgt gtttgtatgt gcatacgtat gagataggca catgcatctt   2520

ctgtatggac aaaggtgggg tacctacagg agagcaaagg ttaattttgt gcttttagta   2580

aaaacattta aatacaaagt tctttattgg gtggaattat atttgatgca aatatttgat   2640

cacttaaaac ttttaaaact tctaggtaat ttgccacgct ttttgactgc tcaccaatac   2700

cctgtaaaaa tacgtaattc ttcctgtttg tgtaataaga tattcatatt tgtagttgca   2760

ttaataatag ttatttctta gtccatcaga tgttcccgtg tgcctctttt atgccaaatt   2820

gattgtcata tttcatgttg ggaccaagta gtttgcccat ggcaaaccta aatttatgac   2880

ctgctgaggc ctctcagaaa actgagcata ctagcaagac agctcttctt gaaaaaaaaa   2940

atatgtatac acaaatatat acgtatatct atatatacgt atgtatatac acacatgtat   3000

attcttcctt gattgtgtag ctgtccaaaa taataacata tatagaggga gctgtattcc   3060

tttatacaaa tctgatggct cctgcagcac tttttccttc tgaaaatatt tacattttgc   3120

taacctagtt tgttacttta aaaatcagtt ttgatgaaag gagggaaaag cagatggact   3180

tgaaaaagat ccaagctcct attagaaaag gtatgaaaat ctttatagta aaatttttta   3240

taaactaaag ttgtaccttt taatatgtag taaactctca tttatttggg gttcgctctt   3300

ggatctcatc catccattgt gttctcttta atgctgcctg ccttttgagg cattcactgc   3360

cctagacaat gccaccagag atagtggggg aaatgccaga tgaaaccaac tcttgctctc   3420

actagttgtc agcttctctg gataagtgac cacagaagca ggagtcctcc tgcttgggca   3480

tcattgggcc agttccttct ctttaaatca gatttgtaat ggctcccaaa ttccatcaca   3540

tcacatttaa attgcagaca gtgttttgca catcatgtat ctgttttgtc ccataatatg   3600

ctttttactc cctgatccca gtttctgctg ttgactcttc cattcagttt tatttattgt   3660

gtgttctcac agtgacacca tttgtccttt tctgcaacaa cctttccagc tacttttgcc   3720

aaattctatt tgtcttctcc ttcaaaacat tctcctttgc agttcctctt catctgtgta   3780

gctgctcttt tgtctcttaa cttaccattc ctatagtact ttatgcatct ctgcttagtt   3840

ctattagttt tttggccttg ctcttctcct tgattttaaa attccttcta tagctagagc   3900

ttttctttct ttcattctct cttcctgcag tgttttgcat acatcagaag ctaggtacat   3960

aagttaaatg attgagagtt ggctgtattt agatttatca ctttttaata gggtgagctt   4020

gagagttttc tttctttctg tttttttttt ttgttttttt tttttttttt tttttttttt   4080

tttttgacta atttcacatg ctctaaaaac cttcaaaggt gattattttt ctcctggaaa   4140

ctccaggtcc attctgttta aatccctaag aatgtcagaa ttaaaataac agggctatcc   4200

cgtaattgga aatatttctt ttttcaggat gctatagtca atttagtaag tgaccaccaa   4260

attgttattt gcactaacaa agctcaaaac acgataagtt tactcctcca tctcagtaat   4320

aaaaattaag ctgtaatcaa ccttctaggt ttctcttgtc ttaaaatggg tattcaaaaa   4380

tggggatctg tggtgtatgt atggaaacac atactcctta atttacctgt tgttggaaac   4440

tggagaaatg attgtcgggc aaccgtttat tttttattgt attttatttg gttgagggat   4500

ttttttataa acagttttac ttgtgtcata ttttaaaatt actaactgcc atcacctgct   4560

ggggtccttt gttaggtcat tttcagtgac taatagggat aatccaggta actttgaaga   4620

gatgagcagt gagtgaccag gcagtttttc tgcctttagc tttgacagtt cttaattaag   4680

atcattgaag accagctttc tcataaattt ctctttttga aaaaaagaaa gcatttgtac   4740

taagctcctc tgtaagacaa catcttaaat cttaaaagtg ttgttatcat gactggtgag   4800

agaagaaaac attttgtttt tattaaatgg agcattattt acaaaaagcc attgttgaga   4860

attagatccc acatcgtata aatatctatt aaccattcta aataaagaga actccagtgt   4920

tgctatgtgc aagatcctct cttggagctt ttttgcatag caattaaagg tgtgctattt   4980

gtcagtagcc atttttttgc agtgatttga agaccaaagt tgttttacag ctgtgttacc   5040

gttaaaggtt ttttttttta tatgtattaa atcaatttat cactgtttaa agctttgaat   5100

atctgcaatc tttgccaagg tactttttta tttaaaaaaa aacataactt tgtaaatatt   5160

accctgtaat attatatata cttaataaaa cattttaagc tattttgttg ggctatttct   5220

attgctgcta cagcagacca caagcacatt tctgaaaaat ttaatttatt aatgtatttt   5280

taagttgctt atattctagg taacaatgta aagaatgatt taaaatatta attatgaatt   5340

ttttgagtat aatacccaat aagcttttaa ttagagcaga gttttaatta aaagttttaa   5400

atcagtcca                                                           5409


<210>  1655
<211>  301
<212>  PRT
<213>  Homo sapiens

<400>  1655


Met Trp Pro Leu Val Ala Ala Leu Leu Leu Gly Ser Ala Cys Cys Gly 
1               5                   10                  15      


Ser Ala Gln Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe 
            20                  25                  30          


Cys Asn Asp Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala 
        35                  40                  45              


Gln Asn Thr Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp 
    50                  55                  60                  


Ile Tyr Thr Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp 
65                  70                  75                  80  


Phe Ser Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala 
                85                  90                  95      


Ser Leu Lys Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr 
            100                 105                 110         


Thr Cys Glu Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu 
        115                 120                 125             


Leu Lys Tyr Arg Val Val Ser Trp Phe Ser Pro Asn Glu Asn Ile Leu 
    130                 135                 140                 


Ile Val Ile Phe Pro Ile Phe Ala Ile Leu Leu Phe Trp Gly Gln Phe 
145                 150                 155                 160 


Gly Ile Lys Thr Leu Lys Tyr Arg Ser Gly Gly Met Asp Glu Lys Thr 
                165                 170                 175     


Ile Ala Leu Leu Val Ala Gly Leu Val Ile Thr Val Ile Val Ile Val 
            180                 185                 190         


Gly Ala Ile Leu Phe Val Pro Gly Glu Tyr Ser Leu Lys Asn Ala Thr 
        195                 200                 205             


Gly Leu Gly Leu Ile Val Thr Ser Thr Gly Ile Leu Ile Leu Leu His 
    210                 215                 220                 


Tyr Tyr Val Phe Ser Thr Ala Ile Gly Leu Thr Ser Phe Val Ile Ala 
225                 230                 235                 240 


Ile Leu Val Ile Gln Val Ile Ala Tyr Ile Leu Ala Val Val Gly Leu 
                245                 250                 255     


Ser Leu Cys Ile Ala Ala Cys Ile Pro Met His Gly Pro Leu Leu Ile 
            260                 265                 270         


Ser Gly Leu Ser Ile Leu Ala Leu Ala Gln Leu Leu Gly Leu Val Tyr 
        275                 280                 285             


Met Lys Phe Val Gly Phe Arg Gly Thr Pro Thr Val Ser 
    290                 295                 300     

<210>  1656
<211>  5382
<212>  DNA
<213>  Homo sapiens

<400>  1656
cggggccgag tgcgcgtgcg cggctctcgc gggcggggag caggcggggg agcgggcggg     60

aagcagtggg agcgcgcgtg cgcgcggccg tgcagcctgg gcagtgggtc ctgcctgtga    120

cgcgcggcgg cggtcggtcc tgcctgtaac ggcggcggcg gctgctgctc cggacacctg    180

cggcggcggc ggcgaccccg cggcgggcgc ggagatgtgg cccctggtag cggcgctgtt    240

gctgggctcg gcgtgctgcg gatcagctca gctactattt aataaaacaa aatctgtaga    300

attcacgttt tgtaatgaca ctgtcgtcat tccatgcttt gttactaata tggaggcaca    360

aaacactact gaagtatacg taaagtggaa atttaaagga agagatattt acacctttga    420

tggagctcta aacaagtcca ctgtccccac tgactttagt agtgcaaaaa ttgaagtctc    480

acaattacta aaaggagatg cctctttgaa gatggataag agtgatgctg tctcacacac    540

aggaaactac acttgtgaag taacagaatt aaccagagaa ggtgaaacga tcatcgagct    600

aaaatatcgt gttgtttcat ggttttctcc aaatgaaaat attcttattg ttattttccc    660

aatttttgct atactcctgt tctggggaca gtttggtatt aaaacactta aatatagatc    720

cggtggtatg gatgagaaaa caattgcttt acttgttgct ggactagtga tcactgtcat    780

tgtcattgtt ggagccattc ttttcgtccc aggtgaatat tcattaaaga atgctactgg    840

ccttggttta attgtgactt ctacagggat attaatatta cttcactact atgtgtttag    900

tacagcgatt ggattaacct ccttcgtcat tgccatattg gttattcagg tgatagccta    960

tatcctcgct gtggttggac tgagtctctg tattgcggcg tgtataccaa tgcatggccc   1020

tcttctgatt tcaggtttga gtatcttagc tctagcacaa ttacttggac tagtttatat   1080

gaaatttgtg gcttccaatc agaagactat acaacctcct aggaaagctg tagaggaacc   1140

ccttaatgca ttcaaagaat caaaaggaat gatgaatgat gaataactga agtgaagtga   1200

tggactccga tttggagagt agtaagacgt gaaaggaata cacttgtgtt taagcaccat   1260

ggccttgatg attcactgtt ggggagaaga aacaagaaaa gtaactggtt gtcacctatg   1320

agacccttac gtgattgtta gttaagtttt tattcaaagc agctgtaatt tagttaataa   1380

aataattatg atctatgttg tttgcccaat tgagatccag ttttttgttg ttatttttaa   1440

tcaattaggg gcaatagtag aatggacaat ttccaagaat gatgcctttc aggtcctagg   1500

gcctctggcc tctaggtaac cagtttaaat tggttcaggg tgataactac ttagcactgc   1560

cctggtgatt acccagagat atctatgaaa accagtggct tccatcaaac ctttgccaac   1620

tcaggttcac agcagctttg ggcagttatg gcagtatggc attagctgag aggtgtctgc   1680

cacttctggg tcaatggaat aataaattaa gtacaggcag gaatttggtt gggagcatct   1740

tgtatgatct ccgtatgatg tgatattgat ggagatagtg gtcctcattc ttgggggttg   1800

ccattcccac attccccctt caacaaacag tgtaacaggt ccttcccaga tttagggtac   1860

ttttattgat ggatatgttt tccttttatt cacataaccc cttgaaaccc tgtcttgtcc   1920

tcctgttact tgcttctgct gtacaagatg tagcaccttt tctcctcttt gaacatggtc   1980

tagtgacacg gtagcaccag ttgcaggaag gagccagact tgttctcaga gcactgtgtt   2040

cacacttttc agcaaaaata gctatggttg taacatatgt attcccttcc tctgatttga   2100

aggcaaaaat ctacagtgtt tcttcacttc ttttctgatc tggggcatga aaaaagcaag   2160

attgaaattt gaactatgag tctcctgcat ggcaacaaaa tgtgtgtcac catcaggcca   2220

acaggccagc ccttgaatgg ggatttatta ctgttgtatc tatgttgcat gataaacatt   2280

catcaccttc ctcctgtagt cctgcctcgt actccccttc ccctatgatt gaaaagtaaa   2340

caaaacccac atttcctatc ctggttagaa gaaaattaat gttctgacag ttgtgatcgc   2400

ctggagtact tttagacttt tagcattcgt tttttacctg tttgtggatg tgtgtttgta   2460

tgtgcatacg tatgagatag gcacatgcat cttctgtatg gacaaaggtg gggtacctac   2520

aggagagcaa aggttaattt tgtgctttta gtaaaaacat ttaaatacaa agttctttat   2580

tgggtggaat tatatttgat gcaaatattt gatcacttaa aacttttaaa acttctaggt   2640

aatttgccac gctttttgac tgctcaccaa taccctgtaa aaatacgtaa ttcttcctgt   2700

ttgtgtaata agatattcat atttgtagtt gcattaataa tagttatttc ttagtccatc   2760

agatgttccc gtgtgcctct tttatgccaa attgattgtc atatttcatg ttgggaccaa   2820

gtagtttgcc catggcaaac ctaaatttat gacctgctga ggcctctcag aaaactgagc   2880

atactagcaa gacagctctt cttgaaaaaa aaaatatgta tacacaaata tatacgtata   2940

tctatatata cgtatgtata tacacacatg tatattcttc cttgattgtg tagctgtcca   3000

aaataataac atatatagag ggagctgtat tcctttatac aaatctgatg gctcctgcag   3060

cactttttcc ttctgaaaat atttacattt tgctaaccta gtttgttact ttaaaaatca   3120

gttttgatga aaggagggaa aagcagatgg acttgaaaaa gatccaagct cctattagaa   3180

aaggtatgaa aatctttata gtaaaatttt ttataaacta aagttgtacc ttttaatatg   3240

tagtaaactc tcatttattt ggggttcgct cttggatctc atccatccat tgtgttctct   3300

ttaatgctgc ctgccttttg aggcattcac tgccctagac aatgccacca gagatagtgg   3360

gggaaatgcc agatgaaacc aactcttgct ctcactagtt gtcagcttct ctggataagt   3420

gaccacagaa gcaggagtcc tcctgcttgg gcatcattgg gccagttcct tctctttaaa   3480

tcagatttgt aatggctccc aaattccatc acatcacatt taaattgcag acagtgtttt   3540

gcacatcatg tatctgtttt gtcccataat atgcttttta ctccctgatc ccagtttctg   3600

ctgttgactc ttccattcag ttttatttat tgtgtgttct cacagtgaca ccatttgtcc   3660

ttttctgcaa caacctttcc agctactttt gccaaattct atttgtcttc tccttcaaaa   3720

cattctcctt tgcagttcct cttcatctgt gtagctgctc ttttgtctct taacttacca   3780

ttcctatagt actttatgca tctctgctta gttctattag ttttttggcc ttgctcttct   3840

ccttgatttt aaaattcctt ctatagctag agcttttctt tctttcattc tctcttcctg   3900

cagtgttttg catacatcag aagctaggta cataagttaa atgattgaga gttggctgta   3960

tttagattta tcacttttta atagggtgag cttgagagtt ttctttcttt ctgttttttt   4020

tttttgtttt tttttttttt tttttttttt ttttttttga ctaatttcac atgctctaaa   4080

aaccttcaaa ggtgattatt tttctcctgg aaactccagg tccattctgt ttaaatccct   4140

aagaatgtca gaattaaaat aacagggcta tcccgtaatt ggaaatattt cttttttcag   4200

gatgctatag tcaatttagt aagtgaccac caaattgtta tttgcactaa caaagctcaa   4260

aacacgataa gtttactcct ccatctcagt aataaaaatt aagctgtaat caaccttcta   4320

ggtttctctt gtcttaaaat gggtattcaa aaatggggat ctgtggtgta tgtatggaaa   4380

cacatactcc ttaatttacc tgttgttgga aactggagaa atgattgtcg ggcaaccgtt   4440

tattttttat tgtattttat ttggttgagg gattttttta taaacagttt tacttgtgtc   4500

atattttaaa attactaact gccatcacct gctggggtcc tttgttaggt cattttcagt   4560

gactaatagg gataatccag gtaactttga agagatgagc agtgagtgac caggcagttt   4620

ttctgccttt agctttgaca gttcttaatt aagatcattg aagaccagct ttctcataaa   4680

tttctctttt tgaaaaaaag aaagcatttg tactaagctc ctctgtaaga caacatctta   4740

aatcttaaaa gtgttgttat catgactggt gagagaagaa aacattttgt ttttattaaa   4800

tggagcatta tttacaaaaa gccattgttg agaattagat cccacatcgt ataaatatct   4860

attaaccatt ctaaataaag agaactccag tgttgctatg tgcaagatcc tctcttggag   4920

cttttttgca tagcaattaa aggtgtgcta tttgtcagta gccatttttt tgcagtgatt   4980

tgaagaccaa agttgtttta cagctgtgtt accgttaaag gttttttttt ttatatgtat   5040

taaatcaatt tatcactgtt taaagctttg aatatctgca atctttgcca aggtactttt   5100

ttatttaaaa aaaaacataa ctttgtaaat attaccctgt aatattatat atacttaata   5160

aaacatttta agctattttg ttgggctatt tctattgctg ctacagcaga ccacaagcac   5220

atttctgaaa aatttaattt attaatgtat ttttaagttg cttatattct aggtaacaat   5280

gtaaagaatg atttaaaata ttaattatga attttttgag tataataccc aataagcttt   5340

taattagagc agagttttaa ttaaaagttt taaatcagtc ca                      5382


<210>  1657
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  1657


Met Trp Pro Leu Val Ala Ala Leu Leu Leu Gly Ser Ala Cys Cys Gly 
1               5                   10                  15      


Ser Ala Gln Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe 
            20                  25                  30          


Cys Asn Asp Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala 
        35                  40                  45              


Gln Asn Thr Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp 
    50                  55                  60                  


Ile Tyr Thr Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp 
65                  70                  75                  80  


Phe Ser Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala 
                85                  90                  95      


Ser Leu Lys Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr 
            100                 105                 110         


Thr Cys Glu Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu 
        115                 120                 125             


Leu Lys Tyr Arg Val Val Ser Trp Phe Ser Pro Asn Glu Asn Ile Leu 
    130                 135                 140                 


Ile Val Ile Phe Pro Ile Phe Ala Ile Leu Leu Phe Trp Gly Gln Phe 
145                 150                 155                 160 


Gly Ile Lys Thr Leu Lys Tyr Arg Ser Gly Gly Met Asp Glu Lys Thr 
                165                 170                 175     


Ile Ala Leu Leu Val Ala Gly Leu Val Ile Thr Val Ile Val Ile Val 
            180                 185                 190         


Gly Ala Ile Leu Phe Val Pro Gly Glu Tyr Ser Leu Lys Asn Ala Thr 
        195                 200                 205             


Gly Leu Gly Leu Ile Val Thr Ser Thr Gly Ile Leu Ile Leu Leu His 
    210                 215                 220                 


Tyr Tyr Val Phe Ser Thr Ala Ile Gly Leu Thr Ser Phe Val Ile Ala 
225                 230                 235                 240 


Ile Leu Val Ile Gln Val Ile Ala Tyr Ile Leu Ala Val Val Gly Leu 
                245                 250                 255     


Ser Leu Cys Ile Ala Ala Cys Ile Pro Met His Gly Pro Leu Leu Ile 
            260                 265                 270         


Ser Gly Leu Ser Ile Leu Ala Leu Ala Gln Leu Leu Gly Leu Val Tyr 
        275                 280                 285             


Met Lys Phe Val Ala Ser Asn Gln Lys Thr Ile Gln Pro Pro Arg Lys 
    290                 295                 300                 


Ala Val Glu Glu Pro Leu Asn Ala Phe Lys Glu Ser Lys Gly Met Met 
305                 310                 315                 320 


Asn Asp Glu 
            

<210>  1658
<211>  3644
<212>  DNA
<213>  Homo sapiens

<400>  1658
caatttccaa gaatgatgcc tttcaggtcc tagggcctct ggcctctagg taaccagttt     60

aaattggttc agggtgataa ctacttagca ctgccctggt gattacccag agatatctat    120

gaaaaccagt ggcttccatc aaacctttgc caactcaggt tcacagcagc tttgggcagt    180

tatggcagta tggcattagc tgagaggtgt ctgccacttc tgggtcaatg gaataataaa    240

ttaagtacag gcaggaattt ggttgggagc atcttgtatg atctccgtat gatgtgatat    300

tgatggagat agtggtcctc attcttgggg gttgccattc ccacattccc ccttcaacaa    360

acagtgtaac aggtccttcc cagatttagg gtacttttat tgatggatat gttttccttt    420

tattcacata accccttgaa accctgtctt gtcctcctgt tacttgcttc tgctgtacaa    480

gatgtagcac cttttctcct ctttgaacat ggtctagtga cacggtagca ccagttgcag    540

gaaggagcca gacttgttct cagagcactg tgttcacact tttcagcaaa aatagctatg    600

gttgtaacat atgtattccc ttcctctgat ttgaaggcaa aaatctacag tgtttcttca    660

cttcttttct gatctggggc atgaaaaaag caagattgaa atttgaacta tgagtctcct    720

gcatggcaac aaaatgtgtg tcaccatcag gccaacaggc cagcccttga atggggattt    780

attactgttg tatctatgtt gcatgataaa cattcatcac cttcctcctg tagtcctgcc    840

tcgtactccc cttcccctat gattgaaaag taaacaaaac ccacatttcc tatcctggtt    900

agaagaaaat taatgttctg acagttgtga tcgcctggag tacttttaga cttttagcat    960

tcgtttttta cctgtttgtg gatgtgtgtt tgtatgtgca tacgtatgag ataggcacat   1020

gcatcttctg tatggacaaa ggtggggtac ctacaggaga gcaaaggtta attttgtgct   1080

tttagtaaaa acatttaaat acaaagttct ttattgggtg gaattatatt tgatgcaaat   1140

atttgatcac ttaaaacttt taaaacttct aggtaatttg ccacgctttt tgactgctca   1200

ccaataccct gtaaaaatac gtaattcttc ctgtttgtgt aataagatat tcatatttgt   1260

agttgcatta ataatagtta tttcttagtc catcagatgt tcccgtgtgc ctcttttatg   1320

ccaaattgat tgtcatattt catgttggga ccaagtagtt tgcccatggc aaacctaaat   1380

ttatgacctg ctgaggcctc tcagaaaact gagcatacta gcaagacagc tcttcttgaa   1440

aaaaaaaatt tgattgtgta gctgtccaaa ataataacat atatagaggg agctgtattc   1500

ctttatacaa atctgatggc tcctgcagca ctttttcctt ctgaaaatat ttacattttg   1560

ctaacctagt ttgttacttt aaaaatcagt tttgatgaaa ggagggaaaa gcagatggac   1620

ttgaaaaaga tccaagctcc tattagaaaa ggtatgaaaa tctttatagt aaaatttttt   1680

ataaactaaa gttgtacctt ttaatatgta gtaaactctc atttatttgg ggttcgctct   1740

tggatctcat ccatccattg tgttctcttt aatgctgcct gccttttgag gcattcactg   1800

ccctagacaa tgccaccaga gatagtgggg gaaatgccag atgaaaccaa ctcttgctct   1860

cactagttgt cagcttctct ggataagtga ccacagaagc aggagtcctc ctgcttgggc   1920

atcattgggc cagttccttc tctttaaatc agatttgtaa tggctcccaa attccatcac   1980

atcacattta aattgcagac agtgttttgc acatcatgta tctgttttgt cccataatat   2040

gctttttact ccctgatccc agtttctgct gttgactctt ccattcagtt ttatttattg   2100

tgtgttctca cagtgacacc atttgtcctt ttctgcaaca acctttccag ctacttttgc   2160

caaattctat ttgtcttctc cttcaaaaca ttctcctttg cagttcctct tcatctgtgt   2220

agctgctctt ttgtctctta acttaccatt cctatagtac tttatgcatc tctgcttagt   2280

tctattagtt ttttggcctt gctcttctcc ttgattttaa aattccttct atagctagag   2340

cttttctttc tttcattctc tcttcctgca gtgttttgca tacatcagaa gctaggtaca   2400

taagttaaat gattgagagt tggctgtatt tagatttatc actttttaat agggtgagct   2460

tgagagtttt ctttctttct gttttttttt tttgtttttt tttttttttt tttttttttt   2520

ttttttgact aatttcacat gctctaaaaa ccttcaaagg tgattatttt tctcctggaa   2580

actccaggtc cattctgttt aaatccctaa gaatgtcaga attaaaataa cagggctatc   2640

ccgtaattgg aaatatttct tttttcagga tgctatagtc aatttagtaa gtgaccacca   2700

aattgttatt tgcactaaca aagctcaaaa cacgataagt ttactcctcc atctcagtaa   2760

taaaaattaa gctgtaatca accttctagg tttctcttgt cttaaaatgg gtattcaaaa   2820

atggggatct gtggtgtatg tatggaaaca catactcctt aatttacctg ttgttggaaa   2880

ctggagaaat gattgtcggg caaccgttta ttttttattg tattttattt ggttgaggga   2940

tttttttata aacagtttta cttgtgtcat attttaaaat tactaactgc catcacctgc   3000

tggggtcctt tgttaggtca ttttcagtga ctaataggga taatccaggt aactttgaag   3060

agatgagcag tgagtgacca ggcagttttt ctgcctttag ctttgacagt tcttaattaa   3120

gatcattgaa gaccagcttt ctcataaatt tctctttttg aaaaaaagaa agcatttgta   3180

ctaagctcct ctgtaagaca acatcttaaa tcttaaaagt gttgttatca tgactggtga   3240

gagaagaaaa cattttgttt ttattaaatg gagcattatt tacaaaaagc cattgttgag   3300

aattagatcc cacatcgtat aaatatctat taaccattct aaataaagag aactccagtg   3360

ttgctatgtg caagatcctc tcttggagct tttttgcata gcaattaaag gtgtgctatt   3420

tgtcagtagc catttttttg cagtgatttg aagaccaaag ttgttttaca gctgtgttac   3480

cgttaaaggt tttttttttt atatgtatta aatcaattta tcactgttta aagctttgaa   3540

tatctgcaat ctttgccaag gtactttttt atttaaaaaa aaacataact ttgtaaatat   3600

taccctgtaa tattatatat acttaataaa acattttaag ctat                    3644


<210>  1659
<211>  89
<212>  PRT
<213>  Homo sapiens

<400>  1659


Met His Leu Leu Tyr Gly Gln Arg Trp Gly Thr Tyr Arg Arg Ala Lys 
1               5                   10                  15      


Val Asn Phe Val Leu Leu Val Lys Thr Phe Lys Tyr Lys Val Leu Tyr 
            20                  25                  30          


Trp Val Glu Leu Tyr Leu Met Gln Ile Phe Asp His Leu Lys Leu Leu 
        35                  40                  45              


Lys Leu Leu Gly Asn Leu Pro Arg Phe Leu Thr Ala His Gln Tyr Pro 
    50                  55                  60                  


Val Lys Ile Arg Asn Ser Ser Cys Leu Cys Asn Lys Ile Phe Ile Phe 
65                  70                  75                  80  


Val Val Ala Leu Ile Ile Val Ile Ser 
                85                  

<210>  1660
<211>  3952
<212>  DNA
<213>  Homo sapiens

<400>  1660
acgaatagtg attatgtgtt catttttcaa ttttccagaa taactgaagt gaagtgatgg     60

actccgattt ggagagtagt aagacgtgaa aggaatacac ttgtgtttaa gcaccatggc    120

cttgatgatt cactgttggg gagaagaaac aagaaaagta actggttgtc acctatgaga    180

cccttacgtg attgttagtt aagtttttat tcaaagcagc tgtaatttag ttaataaaat    240

aattatgatc tatgttgttt gcccaattga gatccagttt tttgttgtta tttttaatca    300

attaggggca atagtagaat ggacaatttc caagaatgat gcctttcagg tcctagggcc    360

tctggcctct aggtaaccag tttaaattgg ttcagggtga taactactta gcactgccct    420

ggtgattacc cagagatatc tatgaaaacc agtggcttcc atcaaacctt tgccaactca    480

ggttcacagc agctttgggc agttatggca gtatggcatt agctgagagg tgtctgccac    540

ttctgggtca atggaataat aaattaagta caggcaggaa tttggttggg agcatcttgt    600

atgatctccg tatgatgtga tattgatgga gatagtggtc ctcattcttg ggggttgcca    660

ttcccacatt cccccttcaa caaacagtgt aacaggtcct tcccagattt agggtacttt    720

tattgatgga tatgttttcc ttttattcac ataacccctt gaaaccctgt cttgtcctcc    780

tgttacttgc ttctgctgta caagatgtag caccttttct cctctttgaa catggtctag    840

tgacacggta gcaccagttg caggaaggag ccagacttgt tctcagagca ctgtgttcac    900

acttttcagc aaaaatagct atggttgtaa catatgtatt cccttcctct gatttgaagg    960

caaaaatcta cagtgtttct tcacttcttt tctgatctgg ggcatgaaaa aagcaagatt   1020

gaaatttgaa ctatgagtct cctgcatggc aacaaaatgt gtgtcaccat caggccaaca   1080

ggccagcctc cccttcccct atgattgaaa agtaaacaaa acccacattt cctatcctgg   1140

ttagaagaaa attaatgttc tgacagttgt gatcgcctgg agtactttta gacttttagc   1200

attcgttttt tacctgtttg tggatgtgtg tttgtatgtg catacgtatg agataggcac   1260

atgcatcttc tgtatggaca aaggtggggt acctacagga gagcaaaggt taattttgtg   1320

cttttagtaa aaacatttaa atacaaagtt ctttattggg tggaattata tttgatgcaa   1380

atatttgatc acttaaaact tttaaaactt ctaggtaatt tgccacgctt tttgactgct   1440

caccaatacc ctgtaaaaat acgtaattct tcctgtttgt gtaataagat attcatattt   1500

gtagttgcat taataatagt tatttcttag tccatcagat gttcccgtgt gcctctttta   1560

tgccaaattg attgtcatat ttcatgttgg gaccaagtag tttgcccatg gcaaacctaa   1620

atttatgacc tgctgaggcc tctcagaaaa ctgagcatac tagcaagaca gctcttcttg   1680

aaaaaaaaaa tatgtataca caaatatata cgtatatcta tatatacgta tgtatataca   1740

cacatgtata ttcttccttg attgtgtagc tgtccaaaat aataacatat atagagggag   1800

ctgtattcct ttatacaaat ctgatggctc ctgcagcact ttttccttct gaaaatattt   1860

acattttgct aacctagttt gttactttaa aaatcagttt tgatgaaagg agggaaaagc   1920

agatggactt gaaaaagatc caagctccta ttagaaaagg tatgaaaatc tttatagtaa   1980

aattttttat aaactaaagt tgtacctttt aatatgtagt aaactctcat ttatttgggg   2040

ttcgctcttg gatctcatcc atccattgtg ttctctttaa tgctgcctgc cttttgaggc   2100

attcactgcc ctagacaatg ccaccagaga tagtggggga aatgccagat gaaaccaact   2160

cttgctctca ctagttgtca gcttctctgg ataagtgacc acagaagcag gagtcctcct   2220

gcttgggcat cattgggcca gttccttctc tttaaatcag atttgtaatg gctcccaaat   2280

tccatcacat cacatttaaa ttgcagacag tgttttgcac atcatgtatc tgttttgtcc   2340

cataatatgc tttttactcc ctgatcccag tttctgctgt tgactcttcc attcagtttt   2400

atttattgtg tgttctcaca gtgacaccat ttgtcctttt ctgcaacaac ctttccagct   2460

acttttgcca aattctattt gtcttctcct tcaaaacatt ctcctttgca gttcctcttc   2520

atctgtgtag ctgctctttt gtctcttaac ttaccattcc tatagtactt tatgcatctc   2580

tgcttagttc tattagtttt ttggccttgc tcttctcctt gattttaaaa ttccttctat   2640

agctagagct tttctttctt tcattctctc ttcctgcagt gttttgcata catcagaagc   2700

taggtacata agttaaatga ttgagagttg gctgtattta gatttatcac tttttaatag   2760

ggtgagcttg agagttttct ttctttctgt tttttttttt tgtttttttt tttttttttt   2820

tttttttttt ttttgactaa tttcacatgc tctaaaaacc ttcaaaggtg attatttttc   2880

tcctggaaac tccaggtcca ttctgtttaa atccctaaga atgtcagaat taaaataaca   2940

gggctatccc gtaattggaa atatttcttt tttcaggatg ctatagtcaa tttagtaagt   3000

gaccaccaaa ttgttatttg cactaacaaa gctcaaaaca cgataagttt actcctccat   3060

ctcagtaata aaaattaagc tgtaatcaac cttctaggtt tctcttgtct taaaatgggt   3120

attcaaaaat ggggatctgt ggtgtatgta tggaaacaca tactccttaa tttacctgtt   3180

gttggaaact ggagaaatga ttgtcgggca accgtttatt ttttattgta ttttatttgg   3240

ttgagggatt tttttataaa cagttttact tgtgtcatat tttaaaatta ctaactgcca   3300

tcacctgctg gggtcctttg ttaggtcatt ttcagtgact aatagggata atccaggtaa   3360

ctttgaagag atgagcagtg agtgaccagg cagtttttct gcctttagct ttgacagttc   3420

ttaattaaga tcattgaaga ccagctttct cataaatttc tctttttgaa aaaaagaaag   3480

catttgtact aagctcctct gtaagacaac atcttaaatc ttaaaagtgt tgttatcatg   3540

actggtgaga gaagaaaaca ttttgttttt attaaatgga gcattattta caaaaagcca   3600

ttgttgagaa ttagatccca catcgtataa atatctatta accattctaa ataaagagaa   3660

ctccagtgtt gctatgtgca agatcctctc ttggagcttt tttgcatagc aattaaaggt   3720

gtgctatttg tcagtagcca tttttttgca gtgatttgaa gaccaaagtt gttttacagc   3780

tgtgttaccg ttaaaggttt ttttttttat atgtattaaa tcaatttatc actgtttaaa   3840

gctttgaata tctgcaatct ttgccaaggt acttttttat ttaaaaaaaa acataacttt   3900

gtaaatatta ccctgtaata ttatatatac ttaataaaac attttaagct at           3952


<210>  1661
<211>  89
<212>  PRT
<213>  Homo sapiens

<400>  1661


Met His Leu Leu Tyr Gly Gln Arg Trp Gly Thr Tyr Arg Arg Ala Lys 
1               5                   10                  15      


Val Asn Phe Val Leu Leu Val Lys Thr Phe Lys Tyr Lys Val Leu Tyr 
            20                  25                  30          


Trp Val Glu Leu Tyr Leu Met Gln Ile Phe Asp His Leu Lys Leu Leu 
        35                  40                  45              


Lys Leu Leu Gly Asn Leu Pro Arg Phe Leu Thr Ala His Gln Tyr Pro 
    50                  55                  60                  


Val Lys Ile Arg Asn Ser Ser Cys Leu Cys Asn Lys Ile Phe Ile Phe 
65                  70                  75                  80  


Val Val Ala Leu Ile Ile Val Ile Ser 
                85                  

<210>  1662
<211>  4622
<212>  DNA
<213>  Homo sapiens

<400>  1662
gaaaaaggca actcagaaag ctaagaagaa atagatagag gaatactcag agctatctga     60

gtattttctt tagtttgtta gctctttgga gctttgaaac tggaaagacc cagggagtga    120

tgtggagaaa gagactgagc ttgtaagaca caggagcagt gagctaaggg agatggagta    180

gtggggacaa attctggcac attctgtcta cactctgggt agatagagga gggaggatgg    240

agcacccatg gtgggggtat gttggtgaca gcattttccc accagccagt gtaacaagtg    300

gctgatttgg gggaaagatg gcataaacaa atgagagaat gtgtttacta tttgatgtag    360

atgggttatt tgcttcattt ttcaaatcag tgtatataat caagaatatt cagcatgttt    420

gaatagactg tcagagctgg aactctttca ttaacatctc tggcaccttt agttttagcc    480

ctgaacattt tatcttaaaa ttaaacatta ccaaatgcct tagtttattt catttattaa    540

atttatattc ttatttgtta tttatatcag cttccaatca gaagactata caacctccta    600

ggaaagctgt agaggaaccc cttaatgaat aactgaagtg aagtgatgga ctccgatttg    660

gagagtagta agacgtgaaa ggaatacact tgtgtttaag caccatggcc ttgatgattc    720

actgttgggg agaagaaaca agaaaagtaa ctggttgtca cctatgagac ccttacgtga    780

ttgttagtta agtttttatt caaagcagct gtaatttagt taataaaata attatgatct    840

atgttgtttg cccaattgag atccagtttt ttgttgttat ttttaatcaa ttaggggcaa    900

tagtagaatg gacaatttcc aagaatgatg cctttcaggt cctagggcct ctggcctcta    960

ggtaaccagt ttaaattggt tcagggtgat aactacttag cactgccctg gtgattaccc   1020

agagatatct atgaaaacca gtggcttcca tcaaaccttt gccaactcag gttcacagca   1080

gctttgggca gttatggcag tatggcatta gctgagaggt gtctgccact tctgggtcaa   1140

tggaataata aattaagtac aggcaggaat ttggttggga gcatcttgta tgatctccgt   1200

atgatgtgat attgatggag atagtggtcc tcattcttgg gggttgccat tcccacattc   1260

ccccttcaac aaacagtgta acaggtcctt cccagattta gggtactttt attgatggat   1320

atgttttcct tttattcaca taaccccttg aaaccctgtc ttgtcctcct gttacttgct   1380

tctgctgtac aagatgtagc accttttctc ctctttgaac atggtctagt gacacggtag   1440

caccagttgc aggaaggagc cagacttgtt ctcagagcac tgtgttcaca cttttcagca   1500

aaaatagcta tggttgtaac atatgtattc ccttcctctg atttgaaggc aaaaatctac   1560

agtgtttctt cacttctttt ctgatctggg gcatgaaaaa agcaagattg aaatttgaac   1620

tatgagtctc ctgcatggca acaaaatgtg tgtcaccatc aggccaacag gccagccctt   1680

gaatggggat ttattactgt tgtatctatg ttgcatgata aacattcatc accttcctcc   1740

tgtagtcctg cctcgtactc cccttcccct atgattgaaa agtaaacaaa acccacattt   1800

cctatcctgg ttagaagaaa attaatgttc tgacagttgt gatcgcctgg agtactttta   1860

gacttttagc attcgttttt tacctgtttg tggatgtgtg tttgtatgtg catacgtatg   1920

agataggcac atgcatcttc tgtatggaca aaggtggggt acctacagga gagcaaaggt   1980

taattttgtg cttttagtaa aaacatttaa atacaaagtt ctttattggg tggaattata   2040

tttgatgcaa atatttgatc acttaaaact tttaaaactt ctaggtaatt tgccacgctt   2100

tttgactgct caccaatacc ctgtaaaaat acgtaattct tcctgtttgt gtaataagat   2160

attcatattt gtagttgcat taataatagt tatttcttag tccatcagat gttcccgtgt   2220

gcctctttta tgccaaattg attgtcatat ttcatgttgg gaccaagtag tttgcccatg   2280

gcaaacctaa atttatgacc tgctgaggcc tctcagaaaa ctgagcatac tagcaagaca   2340

gctcttcttg aaaaaaaaaa tatgtataca caaatatata cgtatatcta tatatacgta   2400

tgtatataca cacatgtata ttcttccttg attgtgtagc tgtccaaaat aataacatat   2460

atagagggag ctgtattcct ttatacaaat ctgatggctc ctgcagcact ttttccttct   2520

gaaaatattt acattttgct aacctagttt gttactttaa aaatcagttt tgatgaaagg   2580

agggaaaagc agatggactt gaaaaagatc caagctccta ttagaaaagg tatgaaaatc   2640

tttatagtaa aattttttat aaactaaagt tgtacctttt aatatgtagt aaactctcat   2700

ttatttgggg ttcgctcttg gatctcatcc atccattgtg ttctctttaa tgctgcctgc   2760

cttttgaggc attcactgcc ctagacaatg ccaccagaga tagtggggga aatgccagat   2820

gaaaccaact cttgctctca ctagttgtca gcttctctgg ataagtgacc acagaagcag   2880

gagtcctcct gcttgggcat cattgggcca gttccttctc tttaaatcag atttgtaatg   2940

gctcccaaat tccatcacat cacatttaaa ttgcagacag tgttttgcac atcatgtatc   3000

tgttttgtcc cataatatgc tttttactcc ctgatcccag tttctgctgt tgactcttcc   3060

attcagtttt atttattgtg tgttctcaca gtgacaccat ttgtcctttt ctgcaacaac   3120

ctttccagct acttttgcca aattctattt gtcttctcct tcaaaacatt ctcctttgca   3180

gttcctcttc atctgtgtag ctgctctttt gtctcttaac ttaccattcc tatagtactt   3240

tatgcatctc tgcttagttc tattagtttt ttggccttgc tcttctcctt gattttaaaa   3300

ttccttctat agctagagct tttctttctt tcattctctc ttcctgcagt gttttgcata   3360

catcagaagc taggtacata agttaaatga ttgagagttg gctgtattta gatttatcac   3420

tttttaatag ggtgagcttg agagttttct ttctttctgt tttttttttt tgtttttttt   3480

tttttttttt tttttttttt ttttgactaa tttcacatgc tctaaaaacc ttcaaaggtg   3540

attatttttc tcctggaaac tccaggtcca ttctgtttaa atccctaaga atgtcagaat   3600

taaaataaca gggctatccc gtaattggaa atatttcttt tttcaggatg ctatagtcaa   3660

tttagtaagt gaccaccaaa ttgttatttg cactaacaaa gctcaaaaca cgataagttt   3720

actcctccat ctcagtaata aaaattaagc tgtaatcaac cttctaggtt tctcttgtct   3780

taaaatgggt attcaaaaat ggggatctgt ggtgtatgta tggaaacaca tactccttaa   3840

tttacctgtt gttggaaact ggagaaatga ttgtcgggca accgtttatt ttttattgta   3900

ttttatttgg ttgagggatt tttttataaa cagttttact tgtgtcatat tttaaaatta   3960

ctaactgcca tcacctgctg gggtcctttg ttaggtcatt ttcagtgact aatagggata   4020

atccaggtaa ctttgaagag atgagcagtg agtgaccagg cagtttttct gcctttagct   4080

ttgacagttc ttaattaaga tcattgaaga ccagctttct cataaatttc tctttttgaa   4140

aaaaagaaag catttgtact aagctcctct gtaagacaac atcttaaatc ttaaaagtgt   4200

tgttatcatg actggtgaga gaagaaaaca ttttgttttt attaaatgga gcattattta   4260

caaaaagcca ttgttgagaa ttagatccca catcgtataa atatctatta accattctaa   4320

ataaagagaa ctccagtgtt gctatgtgca agatcctctc ttggagcttt tttgcatagc   4380

aattaaaggt gtgctatttg tcagtagcca tttttttgca gtgatttgaa gaccaaagtt   4440

gttttacagc tgtgttaccg ttaaaggttt ttttttttat atgtattaaa tcaatttatc   4500

actgtttaaa gctttgaata tctgcaatct ttgccaaggt acttttttat ttaaaaaaaa   4560

acataacttt gtaaatatta ccctgtaata ttatatatac ttaataaaac attttaagct   4620

at                                                                  4622


<210>  1663
<211>  89
<212>  PRT
<213>  Homo sapiens

<400>  1663


Met His Leu Leu Tyr Gly Gln Arg Trp Gly Thr Tyr Arg Arg Ala Lys 
1               5                   10                  15      


Val Asn Phe Val Leu Leu Val Lys Thr Phe Lys Tyr Lys Val Leu Tyr 
            20                  25                  30          


Trp Val Glu Leu Tyr Leu Met Gln Ile Phe Asp His Leu Lys Leu Leu 
        35                  40                  45              


Lys Leu Leu Gly Asn Leu Pro Arg Phe Leu Thr Ala His Gln Tyr Pro 
    50                  55                  60                  


Val Lys Ile Arg Asn Ser Ser Cys Leu Cys Asn Lys Ile Phe Ile Phe 
65                  70                  75                  80  


Val Val Ala Leu Ile Ile Val Ile Ser 
                85                  

<210>  1664
<211>  4738
<212>  DNA
<213>  Homo sapiens

<400>  1664
ctagggtatt ctttttccct ttcgtcactt tgctcatgta ctgtattcct tcaacttcat     60

taatgaatcc atttggaagc agtgaaaaag gcaactcaga aagctaagaa gaaatagata    120

gaggaatact cagagctatc tgagtatttt ctttagtttg ttagctcttt ggagctttga    180

aactggaaag acccagggag tgatgtggag aaagagactg agcttgtaag acacaggagc    240

agtgagctaa gggagatgga gtagtgggga caaattctgg cacattctgt ctacactctg    300

ggtagataga ggagggagga tggagcaccc atggtggggg tatgttggtg acagcatttt    360

cccaccagcc agtgtaacaa gtggctgatt tgggggaaag atggcataaa caaatgagag    420

aatgtgttta ctatttgatg tagatgggtt atttgcttca tttttcaaat cagtgtatat    480

aatcaagaat attcagcatg tttgaataga ctgtcagagc tggaactctt tcattaacat    540

ctctggcacc tttagtttta gccctgaaca ttttatctta aaattaaaca ttaccaaatg    600

ccttagttta tttcatttat taaatttata ttcttatttg ttatttatat cagcttccaa    660

tcagaagact atacaacctc ctaggaaagc tgtagaggaa ccccttaatg cattcaaaga    720

atcaaaagga atgatgaatg atgaataact gaagtgaagt gatggactcc gatttggaga    780

gtagtaagac gtgaaaggaa tacacttgtg tttaagcacc atggccttga tgattcactg    840

ttggggagaa gaaacaagaa aagtaactgg ttgtcaccta tgagaccctt acgtgattgt    900

tagttaagtt tttattcaaa gcagctgtaa tttagttaat aaaataatta tgatctatgt    960

tgtttgccca attgagatcc agttttttgt tgttattttt aatcaattag gggcaatagt   1020

agaatggaca atttccaaga atgatgcctt tcaggtccta gggcctctgg cctctaggta   1080

accagtttaa attggttcag ggtgataact acttagcact gccctggtga ttacccagag   1140

atatctatga aaaccagtgg cttccatcaa acctttgcca actcaggttc acagcagctt   1200

tgggcagtta tggcagtatg gcattagctg agaggtgtct gccacttctg ggtcaatgga   1260

ataataaatt aagtacaggc aggaatttgg ttgggagcat cttgtatgat ctccgtatga   1320

tgtgatattg atggagatag tggtcctcat tcttgggggt tgccattccc acattccccc   1380

ttcaacaaac agtgtaacag gtccttccca gatttagggt acttttattg atggatatgt   1440

tttcctttta ttcacataac cccttgaaac cctgtcttgt cctcctgtta cttgcttctg   1500

ctgtacaaga tgtagcacct tttctcctct ttgaacatgg tctagtgaca cggtagcacc   1560

agttgcagga aggagccaga cttgttctca gagcactgtg ttcacacttt tcagcaaaaa   1620

tagctatggt tgtaacatat gtattccctt cctctgattt gaaggcaaaa atctacagtg   1680

tttcttcact tcttttctga tctggggcat gaaaaaagca agattgaaat ttgaactatg   1740

agtctcctgc atggcaacaa aatgtgtgtc accatcaggc caacaggcca gcccttgaat   1800

ggggatttat tactgttgta tctatgttgc atgataaaca ttcatcacct tcctcctgta   1860

gtcctgcctc gtactcccct tcccctatga ttgaaaagta aacaaaaccc acatttccta   1920

tcctggttag aagaaaatta atgttctgac agttgtgatc gcctggagta cttttagact   1980

tttagcattc gttttttacc tgtttgtgga tgtgtgtttg tatgtgcata cgtatgagat   2040

aggcacatgc atcttctgta tggacaaagg tggggtacct acaggagagc aaaggttaat   2100

tttgtgcttt tagtaaaaac atttaaatac aaagttcttt attgggtgga attatatttg   2160

atgcaaatat ttgatcactt aaaactttta aaacttctag gtaatttgcc acgctttttg   2220

actgctcacc aataccctgt aaaaatacgt aattcttcct gtttgtgtaa taagatattc   2280

atatttgtag ttgcattaat aatagttatt tcttagtcca tcagatgttc ccgtgtgcct   2340

cttttatgcc aaattgattg tcatatttca tgttgggacc aagtagtttg cccatggcaa   2400

acctaaattt atgacctgct gaggcctctc agaaaactga gcatactagc aagacagctc   2460

ttcttgaaaa aaaaaatatg tatacacaaa tatatacgta tatctatata tacgtatgta   2520

tatacacaca tgtatattct tccttgattg tgtagctgtc caaaataata acatatatag   2580

agggagctgt attcctttat acaaatctga tggctcctgc agcacttttt ccttctgaaa   2640

atatttacat tttgctaacc tagtttgtta ctttaaaaat cagttttgat gaaaggaggg   2700

aaaagcagat ggacttgaaa aagatccaag ctcctattag aaaaggtatg aaaatcttta   2760

tagtaaaatt ttttataaac taaagttgta ccttttaata tgtagtaaac tctcatttat   2820

ttggggttcg ctcttggatc tcatccatcc attgtgttct ctttaatgct gcctgccttt   2880

tgaggcattc actgccctag acaatgccac cagagatagt gggggaaatg ccagatgaaa   2940

ccaactcttg ctctcactag ttgtcagctt ctctggataa gtgaccacag aagcaggagt   3000

cctcctgctt gggcatcatt gggccagttc cttctcttta aatcagattt gtaatggctc   3060

ccaaattcca tcacatcaca tttaaattgc agacagtgtt ttgcacatca tgtatctgtt   3120

ttgtcccata atatgctttt tactccctga tcccagtttc tgctgttgac tcttccattc   3180

agttttattt attgtgtgtt ctcacagtga caccatttgt ccttttctgc aacaaccttt   3240

ccagctactt ttgccaaatt ctatttgtct tctccttcaa aacattctcc tttgcagttc   3300

ctcttcatct gtgtagctgc tcttttgtct cttaacttac cattcctata gtactttatg   3360

catctctgct tagttctatt agttttttgg ccttgctctt ctccttgatt ttaaaattcc   3420

ttctatagct agagcttttc tttctttcat tctctcttcc tgcagtgttt tgcatacatc   3480

agaagctagg tacataagtt aaatgattga gagttggctg tatttagatt tatcactttt   3540

taatagggtg agcttgagag ttttctttct ttctgttttt tttttttgtt tttttttttt   3600

tttttttttt tttttttttt gactaatttc acatgctcta aaaaccttca aaggtgatta   3660

tttttctcct ggaaactcca ggtccattct gtttaaatcc ctaagaatgt cagaattaaa   3720

ataacagggc tatcccgtaa ttggaaatat ttcttttttc aggatgctat agtcaattta   3780

gtaagtgacc accaaattgt tatttgcact aacaaagctc aaaacacgat aagtttactc   3840

ctccatctca gtaataaaaa ttaagctgta atcaaccttc taggtttctc ttgtcttaaa   3900

atgggtattc aaaaatgggg atctgtggtg tatgtatgga aacacatact ccttaattta   3960

cctgttgttg gaaactggag aaatgattgt cgggcaaccg tttatttttt attgtatttt   4020

atttggttga gggatttttt tataaacagt tttacttgtg tcatatttta aaattactaa   4080

ctgccatcac ctgctggggt cctttgttag gtcattttca gtgactaata gggataatcc   4140

aggtaacttt gaagagatga gcagtgagtg accaggcagt ttttctgcct ttagctttga   4200

cagttcttaa ttaagatcat tgaagaccag ctttctcata aatttctctt tttgaaaaaa   4260

agaaagcatt tgtactaagc tcctctgtaa gacaacatct taaatcttaa aagtgttgtt   4320

atcatgactg gtgagagaag aaaacatttt gtttttatta aatggagcat tatttacaaa   4380

aagccattgt tgagaattag atcccacatc gtataaatat ctattaacca ttctaaataa   4440

agagaactcc agtgttgcta tgtgcaagat cctctcttgg agcttttttg catagcaatt   4500

aaaggtgtgc tatttgtcag tagccatttt tttgcagtga tttgaagacc aaagttgttt   4560

tacagctgtg ttaccgttaa aggttttttt ttttatatgt attaaatcaa tttatcactg   4620

tttaaagctt tgaatatctg caatctttgc caaggtactt ttttatttaa aaaaaaacat   4680

aactttgtaa atattaccct gtaatattat atatacttaa taaaacattt taagctat     4738


<210>  1665
<211>  89
<212>  PRT
<213>  Homo sapiens

<400>  1665


Met His Leu Leu Tyr Gly Gln Arg Trp Gly Thr Tyr Arg Arg Ala Lys 
1               5                   10                  15      


Val Asn Phe Val Leu Leu Val Lys Thr Phe Lys Tyr Lys Val Leu Tyr 
            20                  25                  30          


Trp Val Glu Leu Tyr Leu Met Gln Ile Phe Asp His Leu Lys Leu Leu 
        35                  40                  45              


Lys Leu Leu Gly Asn Leu Pro Arg Phe Leu Thr Ala His Gln Tyr Pro 
    50                  55                  60                  


Val Lys Ile Arg Asn Ser Ser Cys Leu Cys Asn Lys Ile Phe Ile Phe 
65                  70                  75                  80  


Val Val Ala Leu Ile Ile Val Ile Ser 
                85                  

<210>  1666
<211>  4314
<212>  DNA
<213>  Homo sapiens

<400>  1666
gcagaaatcg taataattct tttgtcacat gggttatatc catattggag agaattaact     60

caggtgaaat taacttgtac actgtttggt tttataatat ttagagggat cacaactgac    120

tgatgtccct ttgaagtacc attcttcata aatctttttt tttcagaatg ggccagccaa    180

ctgtgacatc ccttggatcg gagatttaga actagaaagt attctttcta cattattagg    240

gaagaaaagg agttacttgg cgcttccaat cagaagacta tacaacctcc taggaaagct    300

gtagaggaac cccttaatga ataactgaag tgaagtgatg gactccgatt tggagagtag    360

taagacgtga aaggaataca cttgtgttta agcaccatgg ccttgatgat tcactgttgg    420

ggagaagaaa caagaaaagt aactggttgt cacctatgag acccttacgt gattgttagt    480

taagttttta ttcaaagcag ctgtaattta gttaataaaa taattatgat ctatgttgtt    540

tgcccaattg agatccagtt ttttgttgtt atttttaatc aattaggggc aatagtagaa    600

tggacaattt ccaagaatga tgcctttcag gtcctagggc ctctggcctc taggtaacca    660

gtttaaattg gttcagggtg ataactactt agcactgccc tggtgattac ccagagatat    720

ctatgaaaac cagtggcttc catcaaacct ttgccaactc aggttcacag cagctttggg    780

cagttatggc agtatggcat tagctgagag gtgtctgcca cttctgggtc aatggaataa    840

taaattaagt acaggcagga atttggttgg gagcatcttg tatgatctcc gtatgatgtg    900

atattgatgg agatagtggt cctcattctt gggggttgcc attcccacat tcccccttca    960

acaaacagtg taacaggtcc ttcccagatt tagggtactt ttattgatgg atatgttttc   1020

cttttattca cataacccct tgaaaccctg tcttgtcctc ctgttacttg cttctgctgt   1080

acaagatgta gcaccttttc tcctctttga acatggtcta gtgacacggt agcaccagtt   1140

gcaggaagga gccagacttg ttctcagagc actgtgttca cacttttcag caaaaatagc   1200

tatggttgta acatatgtat tcccttcctc tgatttgaag gcaaaaatct acagtgtttc   1260

ttcacttctt ttctgatctg gggcatgaaa aaagcaagat tgaaatttga actatgagtc   1320

tcctgcatgg caacaaaatg tgtgtcacca tcaggccaac aggccagccc ttgaatgggg   1380

atttattact gttgtatcta tgttgcatga taaacattca tcaccttcct cctgtagtcc   1440

tgcctcgtac tccccttccc ctatgattga aaagtaaaca aaacccacat ttcctatcct   1500

ggttagaaga aaattaatgt tctgacagtt gtgatcgcct ggagtacttt tagactttta   1560

gcattcgttt tttacctgtt tgtggatgtg tgtttgtatg tgcatacgta tgagataggc   1620

acatgcatct tctgtatgga caaaggtggg gtacctacag gagagcaaag gttaattttg   1680

tgcttttagt aaaaacattt aaatacaaag ttctttattg ggtggaatta tatttgatgc   1740

aaatatttga tcacttaaaa cttttaaaac ttctaggtaa tttgccacgc tttttgactg   1800

ctcaccaata ccctgtaaaa atacgtaatt cttcctgttt gtgtaataag atattcatat   1860

ttgtagttgc attaataata gttatttctt agtccatcag atgttcccgt gtgcctcttt   1920

tatgccaaat tgattgtcat atttcatgtt gggaccaagt agtttgccca tggcaaacct   1980

aaatttatga cctgctgagg cctctcagaa aactgagcat actagcaaga cagctcttct   2040

tgaaaaaaaa aatatgtata cacaaatata tacgtatatc tatatatacg tatgtatata   2100

cacacatgta tattcttcct tgattgtgta gctgtccaaa ataataacat atatagaggg   2160

agctgtattc ctttatacaa atctgatggc tcctgcagca ctttttcctt ctgaaaatat   2220

ttacattttg ctaacctagt ttgttacttt aaaaatcagt tttgatgaaa ggagggaaaa   2280

gcagatggac ttgaaaaaga tccaagctcc tattagaaaa ggtatgaaaa tctttatagt   2340

aaaatttttt ataaactaaa gttgtacctt ttaatatgta gtaaactctc atttatttgg   2400

ggttcgctct tggatctcat ccatccattg tgttctcttt aatgctgcct gccttttgag   2460

gcattcactg ccctagacaa tgccaccaga gatagtgggg gaaatgccag atgaaaccaa   2520

ctcttgctct cactagttgt cagcttctct ggataagtga ccacagaagc aggagtcctc   2580

ctgcttgggc atcattgggc cagttccttc tctttaaatc agatttgtaa tggctcccaa   2640

attccatcac atcacattta aattgcagac agtgttttgc acatcatgta tctgttttgt   2700

cccataatat gctttttact ccctgatccc agtttctgct gttgactctt ccattcagtt   2760

ttatttattg tgtgttctca cagtgacacc atttgtcctt ttctgcaaca acctttccag   2820

ctacttttgc caaattctat ttgtcttctc cttcaaaaca ttctcctttg cagttcctct   2880

tcatctgtgt agctgctctt ttgtctctta acttaccatt cctatagtac tttatgcatc   2940

tctgcttagt tctattagtt ttttggcctt gctcttctcc ttgattttaa aattccttct   3000

atagctagag cttttctttc tttcattctc tcttcctgca gtgttttgca tacatcagaa   3060

gctaggtaca taagttaaat gattgagagt tggctgtatt tagatttatc actttttaat   3120

agggtgagct tgagagtttt ctttctttct gttttttttt tttgtttttt tttttttttt   3180

tttttttttt ttttttgact aatttcacat gctctaaaaa ccttcaaagg tgattatttt   3240

tctcctggaa actccaggtc cattctgttt aaatccctaa gaatgtcaga attaaaataa   3300

cagggctatc ccgtaattgg aaatatttct tttttcagga tgctatagtc aatttagtaa   3360

gtgaccacca aattgttatt tgcactaaca aagctcaaaa cacgataagt ttactcctcc   3420

atctcagtaa taaaaattaa gctgtaatca accttctagg tttctcttgt cttaaaatgg   3480

gtattcaaaa atggggatct gtggtgtatg tatggaaaca catactcctt aatttacctg   3540

ttgttggaaa ctggagaaat gattgtcggg caaccgttta ttttttattg tattttattt   3600

ggttgaggga tttttttata aacagtttta cttgtgtcat attttaaaat tactaactgc   3660

catcacctgc tggggtcctt tgttaggtca ttttcagtga ctaataggga taatccaggt   3720

aactttgaag agatgagcag tgagtgacca ggcagttttt ctgcctttag ctttgacagt   3780

tcttaattaa gatcattgaa gaccagcttt ctcataaatt tctctttttg aaaaaaagaa   3840

agcatttgta ctaagctcct ctgtaagaca acatcttaaa tcttaaaagt gttgttatca   3900

tgactggtga gagaagaaaa cattttgttt ttattaaatg gagcattatt tacaaaaagc   3960

cattgttgag aattagatcc cacatcgtat aaatatctat taaccattct aaataaagag   4020

aactccagtg ttgctatgtg caagatcctc tcttggagct tttttgcata gcaattaaag   4080

gtgtgctatt tgtcagtagc catttttttg cagtgatttg aagaccaaag ttgttttaca   4140

gctgtgttac cgttaaaggt tttttttttt atatgtatta aatcaattta tcactgttta   4200

aagctttgaa tatctgcaat ctttgccaag gtactttttt atttaaaaaa aaacataact   4260

ttgtaaatat taccctgtaa tattatatat acttaataaa acattttaag ctat         4314


<210>  1667
<211>  89
<212>  PRT
<213>  Homo sapiens

<400>  1667


Met His Leu Leu Tyr Gly Gln Arg Trp Gly Thr Tyr Arg Arg Ala Lys 
1               5                   10                  15      


Val Asn Phe Val Leu Leu Val Lys Thr Phe Lys Tyr Lys Val Leu Tyr 
            20                  25                  30          


Trp Val Glu Leu Tyr Leu Met Gln Ile Phe Asp His Leu Lys Leu Leu 
        35                  40                  45              


Lys Leu Leu Gly Asn Leu Pro Arg Phe Leu Thr Ala His Gln Tyr Pro 
    50                  55                  60                  


Val Lys Ile Arg Asn Ser Ser Cys Leu Cys Asn Lys Ile Phe Ile Phe 
65                  70                  75                  80  


Val Val Ala Leu Ile Ile Val Ile Ser 
                85                  

<210>  1668
<211>  7307
<212>  DNA
<213>  Homo sapiens

<400>  1668
aagaagttaa tgtcgctatg agatttttaa cttttataat ttttattatt tccaacttta     60

aatttgtagc cttaatttgc tattttaaag agtaggcctt tcactttcta caactttctg    120

tgaaagtgac tttcactttc tattttttaa ctttttaaac tgtgttgtat tttttttctt    180

ttattggaag cattttaatt ttataagatg agaaaaagga ctgggcacaa taacttaatg    240

tgaaagcata gaaaagatta caagaaccta accaaactca ctaaagttgg gcttgttgtt    300

tgtagagaac gtttatataa ttataaggat caatactttc tcatttttaa agccattacc    360

agttagttca atataagggc atatagtgtt ttgatacaaa tcaatctggt agcagtaagt    420

accatattta ccacaacatc ccagatattt tagaatgatg cagatgcaga atatatacgt    480

agaatttata tctatgtata gatacaaatt cagatatttt cttgttcaat ttaaggagag    540

gtaaatttgg tatcaataga aaaaatgttt ctgaaaaatt taaaccctgg aaatgtattt    600

atggcatgga gtcagatgtt tcagggagag aagaacaaat caagaagcat tgcaagtatg    660

ctcatatgga atgcttaagg cttgtggtta aaaaatatat atatatggct gtcaatgtct    720

taggctcatg gtagcagcag aaatcgtaat aattcttttg tcacatgggt tatatccata    780

ttggagagaa ttaactcagg tgaaattaac ttgtacactg tttggtttta taatatttag    840

agggatcaca actgactgat gtccctttga agtaccattc ttcataaatc tttttttttc    900

agaatgggcc agccaactgt gacatccctt ggatcggaga tttagaacta gaaagtattc    960

tttctacatt attagggaag aaaaggagtt acttggcggt tagcaatatt ctattttgtt   1020

ttgttttgtt tttagagaca gggtctcatt atgttgacca ggctggcctc gagctcctgg   1080

gctcaagcaa tgctcccacc tcagcctccc aagtagctgg gactacaggc atgtgccact   1140

acacctggca gtgtttattc tgataaatac atttatgagc tcaaaaatgt aactctaaaa   1200

ccttatctct gaacttccat attaccatca gaaatttaga tagttgttta gttctctttt   1260

tctttgtaga acatagatat aaggcatggt ttcattgaag tcagttgtat atacatgtaa   1320

ctatcctgat gttcccaaat aaagctctgt atttctgctt agtttattgg ggaggctgct   1380

aaatgtagtg catcccaacc cattttaccc tgttctactt taaaaagagg ttggcttctt   1440

gtttggatac aaggaccaag tcactccccc aggttcctcc acagtaaggg aggcctattt   1500

aaagccgccc atggcactaa cagaaactgg actcctatga gctcagatac ataactgggc   1560

ctcacagggg tgggacagta tgtagtctag gaattggaag gatccattcc atatcaaaga   1620

actgaagcat cgtgttgccc tctcagcagc aagagtaagg tgatgcccct gtcagttata   1680

gttcctgagt tcctctgtct ttgattcttt gcctattagc cagctagctc accctcttgt   1740

ttatgccact gttttttatc ctattcatgc cttctcacag acaacttttc ttacctacag   1800

ctttggactc atccttgtct cctttctgtt tctttttcac tttcccttcc catcaccaac   1860

tttctgggtt tttttctgtt tcttcttaga gtccagtggc agggagaaac ttgtcagtcc   1920

agtctgttgc catttttcct gtttgagaaa gactcaccag cttttggctg gctcacagat   1980

tggctttcct tgggtcagga cccacccttt tccctgccag ctttggaagc ttgacagaat   2040

tcgagtgtgc agtggtggta aataaatagt aaggaacaca gagcagtcct ggaggcgtgc   2100

ctccatctgc tgatgagaaa atccagtgct gtcatccagc ccaggtccca gcggaatggg   2160

cctctctgtt cagtaggatc cccctcctgc tgagtggttc atggcatgtt tctgttcaac   2220

gcttttccat ctgtaggatt cttattctgt atttatttgt ttttttgggt ttttttattt   2280

tttgagatgg agtctcgctc tgtcgcccag gctggagtgc agtggcacga ccccagctcg   2340

ctgcagcctc tgcctcccag gacgagggag atcctcccac ctcagccttc cacgtagctg   2400

ggactacagg catgcaccac aggcatgcac caccacgcca gctaattttt gtatttttgg   2460

tagagacagg gttgcatcat gttgcccagg ctggtcttga atgcctgagc tcaagcaatc   2520

tatttgcctt ggcctcccaa agtgctggga ttacaggcat gagccaccac ggccagcctt   2580

ctcatttgtt ttttttataa ggaagctatc tcttcttccc tccccaacta gggtattctt   2640

tttccctttc gtcactttgc tcatgtactg tattccttca acttcattaa tgaatccatt   2700

tggaagcagt gaaaaaggca actcagaaag ctaagaagaa atagatagag gaatactcag   2760

agctatctga gtattttctt tagtttgtta gctctttgga gctttgaaac tggaaagacc   2820

cagggagtga tgtggagaaa gagactgagc ttgtaagaca caggagcagt gagctaaggg   2880

agatggagta gtggggacaa attctggcac attctgtcta cactctgggt agatagagga   2940

gggaggatgg agcacccatg gtgggggtat gttggtgaca gcattttccc accagccagt   3000

gtaacaagtg gctgatttgg gggaaagatg gcataaacaa atgagagaat gtgtttacta   3060

tttgatgtag atgggttatt tgcttcattt ttcaaatcag tgtatataat caagaatatt   3120

cagcatgttt gaatagactg tcagagctgg aactctttca ttaacatctc tggcaccttt   3180

agttttagcc ctgaacattt tatcttaaaa ttaaacatta ccaaatgcct tagtttattt   3240

catttattaa atttatattc ttatttgtta tttatatcag cttccaatca gaagactata   3300

caacctccta ggaataactg aagtgaagtg atggactccg atttggagag tagtaagacg   3360

tgaaaggaat acacttgtgt ttaagcacca tggccttgat gattcactgt tggggagaag   3420

aaacaagaaa agtaactggt tgtcacctat gagaccctta cgtgattgtt agttaagttt   3480

ttattcaaag cagctgtaat ttagttaata aaataattat gatctatgtt gtttgcccaa   3540

ttgagatcca gttttttgtt gttattttta atcaattagg ggcaatagta gaatggacaa   3600

tttccaagaa tgatgccttt caggtcctag ggcctctggc ctctaggtaa ccagtttaaa   3660

ttggttcagg gtgataacta cttagcactg ccctggtgat tacccagaga tatctatgaa   3720

aaccagtggc ttccatcaaa cctttgccaa ctcaggttca cagcagcttt gggcagttat   3780

ggcagtatgg cattagctga gaggtgtctg ccacttctgg gtcaatggaa taataaatta   3840

agtacaggca ggaatttggt tgggagcatc ttgtatgatc tccgtatgat gtgatattga   3900

tggagatagt ggtcctcatt cttgggggtt gccattccca cattccccct tcaacaaaca   3960

gtgtaacagg tccttcccag atttagggta cttttattga tggatatgtt ttccttttat   4020

tcacataacc ccttgaaacc ctgtcttgtc ctcctgttac ttgcttctgc tgtacaagat   4080

gtagcacctt ttctcctctt tgaacatggt ctagtgacac ggtagcacca gttgcaggaa   4140

ggagccagac ttgttctcag agcactgtgt tcacactttt cagcaaaaat agctatggtt   4200

gtaacatatg tattcccttc ctctgatttg aaggcaaaaa tctacagtgt ttcttcactt   4260

cttttctgat ctggggcatg aaaaaagcaa gattgaaatt tgaactatga gtctcctgca   4320

tggcaacaaa atgtgtgtca ccatcaggcc aacaggccag cccttgaatg gggatttatt   4380

actgttgtat ctatgttgca tgataaacat tcatcacctt cctcctgtag tcctgcctcg   4440

tactcccctt cccctatgat tgaaaagtaa acaaaaccca catttcctat cctggttaga   4500

agaaaattaa tgttctgaca gttgtgatcg cctggagtac ttttagactt ttagcattcg   4560

ttttttacct gtttgtggat gtgtgtttgt atgtgcatac gtatgagata ggcacatgca   4620

tcttctgtat ggacaaaggt ggggtaccta caggagagca aaggttaatt ttgtgctttt   4680

agtaaaaaca tttaaataca aagttcttta ttgggtggaa ttatatttga tgcaaatatt   4740

tgatcactta aaacttttaa aacttctagg taatttgcca cgctttttga ctgctcacca   4800

ataccctgta aaaatacgta attcttcctg tttgtgtaat aagatattca tatttgtagt   4860

tgcattaata atagttattt cttagtccat cagatgttcc cgtgtgcctc ttttatgcca   4920

aattgattgt catatttcat gttgggacca agtagtttgc ccatggcaaa cctaaattta   4980

tgacctgctg aggcctctca gaaaactgag catactagca agacagctct tcttgaaaaa   5040

aaaaatatgt atacacaaat atatacgtat atctatatat acgtatgtat atacacacat   5100

gtatattctt ccttgattgt gtagctgtcc aaaataataa catatataga gggagctgta   5160

ttcctttata caaatctgat ggctcctgca gcactttttc cttctgaaaa tatttacatt   5220

ttgctaacct agtttgttac tttaaaaatc agttttgatg aaaggaggga aaagcagatg   5280

gacttgaaaa agatccaagc tcctattaga aaaggtatga aaatctttat agtaaaattt   5340

tttataaact aaagttgtac cttttaatat gtagtaaact ctcatttatt tggggttcgc   5400

tcttggatct catccatcca ttgtgttctc tttaatgctg cctgcctttt gaggcattca   5460

ctgccctaga caatgccacc agagatagtg ggggaaatgc cagatgaaac caactcttgc   5520

tctcactagt tgtcagcttc tctggataag tgaccacaga agcaggagtc ctcctgcttg   5580

ggcatcattg ggccagttcc ttctctttaa atcagatttg taatggctcc caaattccat   5640

cacatcacat ttaaattgca gacagtgttt tgcacatcat gtatctgttt tgtcccataa   5700

tatgcttttt actccctgat cccagtttct gctgttgact cttccattca gttttattta   5760

ttgtgtgttc tcacagtgac accatttgtc cttttctgca acaacctttc cagctacttt   5820

tgccaaattc tatttgtctt ctccttcaaa acattctcct ttgcagttcc tcttcatctg   5880

tgtagctgct cttttgtctc ttaacttacc attcctatag tactttatgc atctctgctt   5940

agttctatta gttttttggc cttgctcttc tccttgattt taaaattcct tctatagcta   6000

gagcttttct ttctttcatt ctctcttcct gcagtgtttt gcatacatca gaagctaggt   6060

acataagtta aatgattgag agttggctgt atttagattt atcacttttt aatagggtga   6120

gcttgagagt tttctttctt tctgtttttt ttttttgttt tttttttttt tttttttttt   6180

tttttttttg actaatttca catgctctaa aaaccttcaa aggtgattat ttttctcctg   6240

gaaactccag gtccattctg tttaaatccc taagaatgtc agaattaaaa taacagggct   6300

atcccgtaat tggaaatatt tcttttttca ggatgctata gtcaatttag taagtgacca   6360

ccaaattgtt atttgcacta acaaagctca aaacacgata agtttactcc tccatctcag   6420

taataaaaat taagctgtaa tcaaccttct aggtttctct tgtcttaaaa tgggtattca   6480

aaaatgggga tctgtggtgt atgtatggaa acacatactc cttaatttac ctgttgttgg   6540

aaactggaga aatgattgtc gggcaaccgt ttatttttta ttgtatttta tttggttgag   6600

ggattttttt ataaacagtt ttacttgtgt catattttaa aattactaac tgccatcacc   6660

tgctggggtc ctttgttagg tcattttcag tgactaatag ggataatcca ggtaactttg   6720

aagagatgag cagtgagtga ccaggcagtt tttctgcctt tagctttgac agttcttaat   6780

taagatcatt gaagaccagc tttctcataa atttctcttt ttgaaaaaaa gaaagcattt   6840

gtactaagct cctctgtaag acaacatctt aaatcttaaa agtgttgtta tcatgactgg   6900

tgagagaaga aaacattttg tttttattaa atggagcatt atttacaaaa agccattgtt   6960

gagaattaga tcccacatcg tataaatatc tattaaccat tctaaataaa gagaactcca   7020

gtgttgctat gtgcaagatc ctctcttgga gcttttttgc atagcaatta aaggtgtgct   7080

atttgtcagt agccattttt ttgcagtgat ttgaagacca aagttgtttt acagctgtgt   7140

taccgttaaa ggtttttttt tttatatgta ttaaatcaat ttatcactgt ttaaagcttt   7200

gaatatctgc aatctttgcc aaggtacttt tttatttaaa aaaaaacata actttgtaaa   7260

tattaccctg taatattata tatacttaat aaaacatttt aagctat                 7307


<210>  1669
<211>  89
<212>  PRT
<213>  Homo sapiens

<400>  1669


Met His Leu Leu Tyr Gly Gln Arg Trp Gly Thr Tyr Arg Arg Ala Lys 
1               5                   10                  15      


Val Asn Phe Val Leu Leu Val Lys Thr Phe Lys Tyr Lys Val Leu Tyr 
            20                  25                  30          


Trp Val Glu Leu Tyr Leu Met Gln Ile Phe Asp His Leu Lys Leu Leu 
        35                  40                  45              


Lys Leu Leu Gly Asn Leu Pro Arg Phe Leu Thr Ala His Gln Tyr Pro 
    50                  55                  60                  


Val Lys Ile Arg Asn Ser Ser Cys Leu Cys Asn Lys Ile Phe Ile Phe 
65                  70                  75                  80  


Val Val Ala Leu Ile Ile Val Ile Ser 
                85                  

<210>  1670
<211>  5098
<212>  DNA
<213>  Homo sapiens

<400>  1670
cggctctcgc gggcggggag caggcggggg agcgggcggg aagcagtggg agcgcgcgtg     60

cgcgcggccg tgcagcctgg gcagtgggtc ctgcctgtga cgcgcggcgg cggtcggtcc    120

tgcctgtaac ggcggcggcg gctgctgctc cggacacctg cggcggcggc ggcgaccccg    180

cggcgggcgc ggagatgtgg cccctggtag cggcgctgtt gctgggctcg gcgtgctgcg    240

gatcagctca gctactattt aataaaacaa aatctgtaga attcacgttt tgtaatgaca    300

ctgtcgtcat tccatgcttt gttactaata tggaggcaca aaacactact gaagtatacg    360

taaagtggaa atttaaagga agagatattt acacctttga tggagctcta aacaagtcca    420

ctgtccccac tgactttagt agtgcaaaaa ttgaagtctc acaattacta aaaggagatg    480

cctctttgaa gatggataag agtgatgctg tctcacacac aggaaactac acttgtgaag    540

taacagaatt aaccagagaa ggtgaaacga tcatcgagct aaaatatcgt gttgtttcat    600

ggttttctcc aaatgaaaat attcttattg ttattttccc aatttttgct atactcctgt    660

tctggggaca gtttggtatt aaaacactta aatatagatc cggtggtatg gatgagaaaa    720

caattgcttt acttgttgct ggactagtga tcactgtcat tgtcattgtt ggagccattc    780

ttttcgtccc aggtgaatat tcattaaaga atgctactgg ccttggttta attgtgactt    840

ctacagggat attaatatta cttcactact atgtgtttag tacagcgatt ggattaacct    900

ccttcgtcat tgccatattg gttattcagg tgatagccta tatcctcgct gtggttggac    960

tgagtctctg tattgcggcg tgtataccaa tgcatggccc tcttctgatt tcaggtttga   1020

gtatcttagc tctagcacaa ttacttggac tagtttatat gaaatttgtg gcttccaatc   1080

agaagactat acaacctcct aggaataact gaagtgaagt gatggactcc gatttggaga   1140

gtagtaagac gtgaaaggaa tacacttgtg tttaagcacc atggccttga tgattcactg   1200

ttggggagaa gaaacaagaa aagtaactgg ttgtcaccta tgagaccctt acgtgattgt   1260

tagttaagtt tttattcaaa gcagctgtaa tttagttaat aaaataatta tgatctatgt   1320

tgtttgccca attgagatcc agttttttgt tgttattttt aatcaattag gggcaatagt   1380

agaatggaca atttccaaga atgatgcctt tcaggtccta gggcctctgg cctctaggta   1440

accagtttaa attggttcag ggtgataact acttagcact gccctggtga ttacccagag   1500

atatctatga aaaccagtgg cttccatcaa acctttgcca actcaggttc acagcagctt   1560

tgggcagtta tggcagtatg gcattagctg agaggtgtct gccacttctg ggtcaatgga   1620

ataataaatt aagtacaggc aggaatttgg ttgggagcat cttgtatgat ctccgtatga   1680

tgtgatattg atggagatag tggtcctcat tcttgggggt tgccattccc acattccccc   1740

ttcaacaaac agtgtaacag gtccttccca gatttagggt acttttattg atggatatgt   1800

tttcctttta ttcacataac cccttgaaac cctgtcttgt cctcctgtta cttgcttctg   1860

ctgtacaaga tgtagcacct tttctcctct ttgaacatgg tctagtgaca cggtagcacc   1920

agttgcagga aggagccaga cttgttctca gagcactgtg ttcacacttt tcagcaaaaa   1980

tagctatggt tgtaacatat gtattccctt cctctgattt gaaggcaaaa atctacagtg   2040

tttcttcact tcttttctga tctggggcat gaaaaaagca agattgaaat ttgaactatg   2100

agtctcctgc atggcaacaa aatgtgtgtc accatcaggc caacaggcca gcccttgaat   2160

ggggatttat tactgttgta tctatgttgc atgataaaca ttcatcacct tcctcctgta   2220

gtcctgcctc gtactcccct tcccctatga ttgaaaagta aacaaaaccc acatttccta   2280

tcctggttag aagaaaatta atgttctgac agttgtgatc gcctggagta cttttagact   2340

tttagcattc gttttttacc tgtttgtgga tgtgtgtttg tatgtgcata cgtatgagat   2400

aggcacatgc atcttctgta tggacaaagg tggggtacct acaggagagc aaaggttaat   2460

tttgtgcttt tagtaaaaac atttaaatac aaagttcttt attgggtgga attatatttg   2520

atgcaaatat ttgatcactt aaaactttta aaacttctag gtaatttgcc acgctttttg   2580

actgctcacc aataccctgt aaaaatacgt aattcttcct gtttgtgtaa taagatattc   2640

atatttgtag ttgcattaat aatagttatt tcttagtcca tcagatgttc ccgtgtgcct   2700

cttttatgcc aaattgattg tcatatttca tgttgggacc aagtagtttg cccatggcaa   2760

acctaaattt atgacctgct gaggcctctc agaaaactga gcatactagc aagacagctc   2820

ttcttgaaaa aaaaaatatg tatacacaaa tatatacgta tatctatata tacgtatgta   2880

tatacacaca tgtatattct tccttgattg tgtagctgtc caaaataata acatatatag   2940

agggagctgt attcctttat acaaatctga tggctcctgc agcacttttt ccttctgaaa   3000

atatttacat tttgctaacc tagtttgtta ctttaaaaat cagttttgat gaaaggaggg   3060

aaaagcagat ggacttgaaa aagatccaag ctcctattag aaaaggtatg aaaatcttta   3120

tagtaaaatt ttttataaac taaagttgta ccttttaata tgtagtaaac tctcatttat   3180

ttggggttcg ctcttggatc tcatccatcc attgtgttct ctttaatgct gcctgccttt   3240

tgaggcattc actgccctag acaatgccac cagagatagt gggggaaatg ccagatgaaa   3300

ccaactcttg ctctcactag ttgtcagctt ctctggataa gtgaccacag aagcaggagt   3360

cctcctgctt gggcatcatt gggccagttc cttctcttta aatcagattt gtaatggctc   3420

ccaaattcca tcacatcaca tttaaattgc agacagtgtt ttgcacatca tgtatctgtt   3480

ttgtcccata atatgctttt tactccctga tcccagtttc tgctgttgac tcttccattc   3540

agttttattt attgtgtgtt ctcacagtga caccatttgt ccttttctgc aacaaccttt   3600

ccagctactt ttgccaaatt ctatttgtct tctccttcaa aacattctcc tttgcagttc   3660

ctcttcatct gtgtagctgc tcttttgtct cttaacttac cattcctata gtactttatg   3720

catctctgct tagttctatt agttttttgg ccttgctctt ctccttgatt ttaaaattcc   3780

ttctatagct agagcttttc tttctttcat tctctcttcc tgcagtgttt tgcatacatc   3840

agaagctagg tacataagtt aaatgattga gagttggctg tatttagatt tatcactttt   3900

taatagggtg agcttgagag ttttctttct ttctgttttt tttttttgtt tttttttttt   3960

tttttttttt tttttttttt gactaatttc acatgctcta aaaaccttca aaggtgatta   4020

tttttctcct ggaaactcca ggtccattct gtttaaatcc ctaagaatgt cagaattaaa   4080

ataacagggc tatcccgtaa ttggaaatat ttcttttttc aggatgctat agtcaattta   4140

gtaagtgacc accaaattgt tatttgcact aacaaagctc aaaacacgat aagtttactc   4200

ctccatctca gtaataaaaa ttaagctgta atcaaccttc taggtttctc ttgtcttaaa   4260

atgggtattc aaaaatgggg atctgtggtg tatgtatgga aacacatact ccttaattta   4320

cctgttgttg gaaactggag aaatgattgt cgggcaaccg tttatttttt attgtatttt   4380

atttggttga gggatttttt tataaacagt tttacttgtg tcatatttta aaattactaa   4440

ctgccatcac ctgctggggt cctttgttag gtcattttca gtgactaata gggataatcc   4500

aggtaacttt gaagagatga gcagtgagtg accaggcagt ttttctgcct ttagctttga   4560

cagttcttaa ttaagatcat tgaagaccag ctttctcata aatttctctt tttgaaaaaa   4620

agaaagcatt tgtactaagc tcctctgtaa gacaacatct taaatcttaa aagtgttgtt   4680

atcatgactg gtgagagaag aaaacatttt gtttttatta aatggagcat tatttacaaa   4740

aagccattgt tgagaattag atcccacatc gtataaatat ctattaacca ttctaaataa   4800

agagaactcc agtgttgcta tgtgcaagat cctctcttgg agcttttttg catagcaatt   4860

aaaggtgtgc tatttgtcag tagccatttt tttgcagtga tttgaagacc aaagttgttt   4920

tacagctgtg ttaccgttaa aggttttttt ttttatatgt attaaatcaa tttatcactg   4980

tttaaagctt tgaatatctg caatctttgc caaggtactt ttttatttaa aaaaaaacat   5040

aactttgtaa atattaccct gtaatattat atatacttaa taaaacattt taagctat     5098


<210>  1671
<211>  305
<212>  PRT
<213>  Homo sapiens

<400>  1671


Met Trp Pro Leu Val Ala Ala Leu Leu Leu Gly Ser Ala Cys Cys Gly 
1               5                   10                  15      


Ser Ala Gln Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe 
            20                  25                  30          


Cys Asn Asp Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala 
        35                  40                  45              


Gln Asn Thr Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp 
    50                  55                  60                  


Ile Tyr Thr Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp 
65                  70                  75                  80  


Phe Ser Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala 
                85                  90                  95      


Ser Leu Lys Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr 
            100                 105                 110         


Thr Cys Glu Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu 
        115                 120                 125             


Leu Lys Tyr Arg Val Val Ser Trp Phe Ser Pro Asn Glu Asn Ile Leu 
    130                 135                 140                 


Ile Val Ile Phe Pro Ile Phe Ala Ile Leu Leu Phe Trp Gly Gln Phe 
145                 150                 155                 160 


Gly Ile Lys Thr Leu Lys Tyr Arg Ser Gly Gly Met Asp Glu Lys Thr 
                165                 170                 175     


Ile Ala Leu Leu Val Ala Gly Leu Val Ile Thr Val Ile Val Ile Val 
            180                 185                 190         


Gly Ala Ile Leu Phe Val Pro Gly Glu Tyr Ser Leu Lys Asn Ala Thr 
        195                 200                 205             


Gly Leu Gly Leu Ile Val Thr Ser Thr Gly Ile Leu Ile Leu Leu His 
    210                 215                 220                 


Tyr Tyr Val Phe Ser Thr Ala Ile Gly Leu Thr Ser Phe Val Ile Ala 
225                 230                 235                 240 


Ile Leu Val Ile Gln Val Ile Ala Tyr Ile Leu Ala Val Val Gly Leu 
                245                 250                 255     


Ser Leu Cys Ile Ala Ala Cys Ile Pro Met His Gly Pro Leu Leu Ile 
            260                 265                 270         


Ser Gly Leu Ser Ile Leu Ala Leu Ala Gln Leu Leu Gly Leu Val Tyr 
        275                 280                 285             


Met Lys Phe Val Ala Ser Asn Gln Lys Thr Ile Gln Pro Pro Arg Asn 
    290                 295                 300                 


Asn 
305 

<210>  1672
<211>  5066
<212>  DNA
<213>  Homo sapiens

<400>  1672
cggctctcgc gggcggggag caggcggggg agcgggcggg aagcagtggg agcgcgcgtg     60

cgcgcggccg tgcagcctgg gcagtgggtc ctgcctgtga cgcgcggcgg cggtcggtcc    120

tgcctgtaac ggcggcggcg gctgctgctc cggacacctg cggcggcggc ggcgaccccg    180

cggcgggcgc ggagatgtgg cccctggtag cggcgctgtt gctgggctcg gcgtgctgcg    240

gatcagctca gctactattt aataaaacaa aatctgtaga attcacgttt tgtaatgaca    300

ctgtcgtcat tccatgcttt gttactaata tggaggcaca aaacactact gaagtatacg    360

taaagtggaa atttaaagga agagatattt acacctttga tggagctcta aacaagtcca    420

ctgtccccac tgactttagt agtgcaaaaa ttgaagtctc acaattacta aaaggagatg    480

cctctttgaa gatggataag agtgatgctg tctcacacac aggaaactac acttgtgaag    540

taacagaatt aaccagagaa ggtgaaacga tcatcgagct aaaatatcgt gttgtttcat    600

ggttttctcc aaatgaaaat attcttattg ttattttccc aatttttgct atactcctgt    660

tctggggaca gtttggtatt aaaacactta aatatagatc cggtggtatg gatgagaaaa    720

caattgcttt acttgttgct ggactagtga tcactgtcat tgtcattgtt ggagccattc    780

ttttcgtccc aggtgaatat tcattaaaga atgctactgg ccttggttta attgtgactt    840

ctacagggat attaatatta cttcactact atgtgtttag tacagcgatt ggattaacct    900

ccttcgtcat tgccatattg gttattcagg tgatagccta tatcctcgct gtggttggac    960

tgagtctctg tattgcggcg tgtataccaa tgcatggccc tcttctgatt tcaggtttga   1020

gtatcttagc tctagcacaa ttacttggac tagtttatat gaaatttgtg gaataactga   1080

agtgaagtga tggactccga tttggagagt agtaagacgt gaaaggaata cacttgtgtt   1140

taagcaccat ggccttgatg attcactgtt ggggagaaga aacaagaaaa gtaactggtt   1200

gtcacctatg agacccttac gtgattgtta gttaagtttt tattcaaagc agctgtaatt   1260

tagttaataa aataattatg atctatgttg tttgcccaat tgagatccag ttttttgttg   1320

ttatttttaa tcaattaggg gcaatagtag aatggacaat ttccaagaat gatgcctttc   1380

aggtcctagg gcctctggcc tctaggtaac cagtttaaat tggttcaggg tgataactac   1440

ttagcactgc cctggtgatt acccagagat atctatgaaa accagtggct tccatcaaac   1500

ctttgccaac tcaggttcac agcagctttg ggcagttatg gcagtatggc attagctgag   1560

aggtgtctgc cacttctggg tcaatggaat aataaattaa gtacaggcag gaatttggtt   1620

gggagcatct tgtatgatct ccgtatgatg tgatattgat ggagatagtg gtcctcattc   1680

ttgggggttg ccattcccac attccccctt caacaaacag tgtaacaggt ccttcccaga   1740

tttagggtac ttttattgat ggatatgttt tccttttatt cacataaccc cttgaaaccc   1800

tgtcttgtcc tcctgttact tgcttctgct gtacaagatg tagcaccttt tctcctcttt   1860

gaacatggtc tagtgacacg gtagcaccag ttgcaggaag gagccagact tgttctcaga   1920

gcactgtgtt cacacttttc agcaaaaata gctatggttg taacatatgt attcccttcc   1980

tctgatttga aggcaaaaat ctacagtgtt tcttcacttc ttttctgatc tggggcatga   2040

aaaaagcaag attgaaattt gaactatgag tctcctgcat ggcaacaaaa tgtgtgtcac   2100

catcaggcca acaggccagc ccttgaatgg ggatttatta ctgttgtatc tatgttgcat   2160

gataaacatt catcaccttc ctcctgtagt cctgcctcgt actccccttc ccctatgatt   2220

gaaaagtaaa caaaacccac atttcctatc ctggttagaa gaaaattaat gttctgacag   2280

ttgtgatcgc ctggagtact tttagacttt tagcattcgt tttttacctg tttgtggatg   2340

tgtgtttgta tgtgcatacg tatgagatag gcacatgcat cttctgtatg gacaaaggtg   2400

gggtacctac aggagagcaa aggttaattt tgtgctttta gtaaaaacat ttaaatacaa   2460

agttctttat tgggtggaat tatatttgat gcaaatattt gatcacttaa aacttttaaa   2520

acttctaggt aatttgccac gctttttgac tgctcaccaa taccctgtaa aaatacgtaa   2580

ttcttcctgt ttgtgtaata agatattcat atttgtagtt gcattaataa tagttatttc   2640

ttagtccatc agatgttccc gtgtgcctct tttatgccaa attgattgtc atatttcatg   2700

ttgggaccaa gtagtttgcc catggcaaac ctaaatttat gacctgctga ggcctctcag   2760

aaaactgagc atactagcaa gacagctctt cttgaaaaaa aaaatatgta tacacaaata   2820

tatacgtata tctatatata cgtatgtata tacacacatg tatattcttc cttgattgtg   2880

tagctgtcca aaataataac atatatagag ggagctgtat tcctttatac aaatctgatg   2940

gctcctgcag cactttttcc ttctgaaaat atttacattt tgctaaccta gtttgttact   3000

ttaaaaatca gttttgatga aaggagggaa aagcagatgg acttgaaaaa gatccaagct   3060

cctattagaa aaggtatgaa aatctttata gtaaaatttt ttataaacta aagttgtacc   3120

ttttaatatg tagtaaactc tcatttattt ggggttcgct cttggatctc atccatccat   3180

tgtgttctct ttaatgctgc ctgccttttg aggcattcac tgccctagac aatgccacca   3240

gagatagtgg gggaaatgcc agatgaaacc aactcttgct ctcactagtt gtcagcttct   3300

ctggataagt gaccacagaa gcaggagtcc tcctgcttgg gcatcattgg gccagttcct   3360

tctctttaaa tcagatttgt aatggctccc aaattccatc acatcacatt taaattgcag   3420

acagtgtttt gcacatcatg tatctgtttt gtcccataat atgcttttta ctccctgatc   3480

ccagtttctg ctgttgactc ttccattcag ttttatttat tgtgtgttct cacagtgaca   3540

ccatttgtcc ttttctgcaa caacctttcc agctactttt gccaaattct atttgtcttc   3600

tccttcaaaa cattctcctt tgcagttcct cttcatctgt gtagctgctc ttttgtctct   3660

taacttacca ttcctatagt actttatgca tctctgctta gttctattag ttttttggcc   3720

ttgctcttct ccttgatttt aaaattcctt ctatagctag agcttttctt tctttcattc   3780

tctcttcctg cagtgttttg catacatcag aagctaggta cataagttaa atgattgaga   3840

gttggctgta tttagattta tcacttttta atagggtgag cttgagagtt ttctttcttt   3900

ctgttttttt tttttgtttt tttttttttt tttttttttt ttttttttga ctaatttcac   3960

atgctctaaa aaccttcaaa ggtgattatt tttctcctgg aaactccagg tccattctgt   4020

ttaaatccct aagaatgtca gaattaaaat aacagggcta tcccgtaatt ggaaatattt   4080

cttttttcag gatgctatag tcaatttagt aagtgaccac caaattgtta tttgcactaa   4140

caaagctcaa aacacgataa gtttactcct ccatctcagt aataaaaatt aagctgtaat   4200

caaccttcta ggtttctctt gtcttaaaat gggtattcaa aaatggggat ctgtggtgta   4260

tgtatggaaa cacatactcc ttaatttacc tgttgttgga aactggagaa atgattgtcg   4320

ggcaaccgtt tattttttat tgtattttat ttggttgagg gattttttta taaacagttt   4380

tacttgtgtc atattttaaa attactaact gccatcacct gctggggtcc tttgttaggt   4440

cattttcagt gactaatagg gataatccag gtaactttga agagatgagc agtgagtgac   4500

caggcagttt ttctgccttt agctttgaca gttcttaatt aagatcattg aagaccagct   4560

ttctcataaa tttctctttt tgaaaaaaag aaagcatttg tactaagctc ctctgtaaga   4620

caacatctta aatcttaaaa gtgttgttat catgactggt gagagaagaa aacattttgt   4680

ttttattaaa tggagcatta tttacaaaaa gccattgttg agaattagat cccacatcgt   4740

ataaatatct attaaccatt ctaaataaag agaactccag tgttgctatg tgcaagatcc   4800

tctcttggag cttttttgca tagcaattaa aggtgtgcta tttgtcagta gccatttttt   4860

tgcagtgatt tgaagaccaa agttgtttta cagctgtgtt accgttaaag gttttttttt   4920

ttatatgtat taaatcaatt tatcactgtt taaagctttg aatatctgca atctttgcca   4980

aggtactttt ttatttaaaa aaaaacataa ctttgtaaat attaccctgt aatattatat   5040

atacttaata aaacatttta agctat                                        5066


<210>  1673
<211>  293
<212>  PRT
<213>  Homo sapiens

<400>  1673


Met Trp Pro Leu Val Ala Ala Leu Leu Leu Gly Ser Ala Cys Cys Gly 
1               5                   10                  15      


Ser Ala Gln Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe 
            20                  25                  30          


Cys Asn Asp Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala 
        35                  40                  45              


Gln Asn Thr Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp 
    50                  55                  60                  


Ile Tyr Thr Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp 
65                  70                  75                  80  


Phe Ser Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala 
                85                  90                  95      


Ser Leu Lys Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr 
            100                 105                 110         


Thr Cys Glu Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu 
        115                 120                 125             


Leu Lys Tyr Arg Val Val Ser Trp Phe Ser Pro Asn Glu Asn Ile Leu 
    130                 135                 140                 


Ile Val Ile Phe Pro Ile Phe Ala Ile Leu Leu Phe Trp Gly Gln Phe 
145                 150                 155                 160 


Gly Ile Lys Thr Leu Lys Tyr Arg Ser Gly Gly Met Asp Glu Lys Thr 
                165                 170                 175     


Ile Ala Leu Leu Val Ala Gly Leu Val Ile Thr Val Ile Val Ile Val 
            180                 185                 190         


Gly Ala Ile Leu Phe Val Pro Gly Glu Tyr Ser Leu Lys Asn Ala Thr 
        195                 200                 205             


Gly Leu Gly Leu Ile Val Thr Ser Thr Gly Ile Leu Ile Leu Leu His 
    210                 215                 220                 


Tyr Tyr Val Phe Ser Thr Ala Ile Gly Leu Thr Ser Phe Val Ile Ala 
225                 230                 235                 240 


Ile Leu Val Ile Gln Val Ile Ala Tyr Ile Leu Ala Val Val Gly Leu 
                245                 250                 255     


Ser Leu Cys Ile Ala Ala Cys Ile Pro Met His Gly Pro Leu Leu Ile 
            260                 265                 270         


Ser Gly Leu Ser Ile Leu Ala Leu Ala Gln Leu Leu Gly Leu Val Tyr 
        275                 280                 285             


Met Lys Phe Val Glu 
    290             

<210>  1674
<211>  5176
<212>  DNA
<213>  Homo sapiens

<400>  1674
cggggccgag tgcgcgtgcg cggctctcgc gggcggggag caggcggggg agcgggcggg     60

aagcagtggg agcgcgcgtg cgcgcggccg tgcagcctgg gcagtgggtc ctgcctgtga    120

cgcgcggcgg cggtcggtcc tgcctgtaac ggcggcggcg gctgctgctc cggacacctg    180

cggcggcggc ggcgaccccg cggcgggcgc ggagatgtgg cccctggtag cggcgctgtt    240

gctgggctcg gcgtgctgcg gatcagctca gctactattt aataaaacaa aatctgtaga    300

attcacgttt tgtaatgaca ctgtcgtcat tccatgcttt gttactaata tggaggcaca    360

aaacactact gaagtatacg taaagtggaa atttaaagga agagatattt acacctttga    420

tggagctcta aacaagtcca ctgtccccac tgactttagt agtgcaaaaa ttgaagtctc    480

acaattacta aaaggagatg cctctttgaa gatggataag agtgatgctg tctcacacac    540

aggaaactac acttgtgaag taacagaatt aaccagagaa ggtgaaacga tcatcgagct    600

aaaatatcgt gttgtttcat ggttttctcc aaatgaaaat attcttattg ttattttccc    660

aatttttgct atactcctgt tctggggaca gtttggtatt aaaacactta aatatagatc    720

cggtggtatg gatgagaaaa caattgcttt acttgttgct ggactagtga tcactgtcat    780

tgtcattgtt ggagccattc ttttcgtccc aggtgaatat tcattaaaga atgctactgg    840

ccttggttta attgtgactt ctacagggat attaatatta cttcactact atgtgtttag    900

tacagcgatt ggattaacct ccttcgtcat tgccatattg gttattcagg tgatagccta    960

tatcctcgct gtggttggac tgagtctctg tattgcggcg tgtataccaa tgcatggccc   1020

tcttctgatt tcaggtttga gtatcttagc tctagcacaa ttacttggac tagtttatat   1080

gaaatttgtg gcttccaatc agaagactat acaacctcct aggaaagctg tagaggaacc   1140

ccttaatgca ttcaaagaat caaaaggaat gatgaatgat gaataactga agtgaagtga   1200

tggactccga tttggagagt agtaagacgt gaaaggaata cacttgtgtt taagcaccat   1260

ggccttgatg attcactgtt ggggagaaga aacaagaaaa gtaactggtt gtcacctatg   1320

agacccttac gtgattgtta gttaagtttt tattcaaagc agctgtaatt tagttaataa   1380

aataattatg atctatgttg tttgcccaat tgagatccag ttttttgttg ttatttttaa   1440

tcaattaggg gcaatagtag aatggacaat ttccaagaat gatgcctttc aggtcctagg   1500

gcctctggcc tctaggtaac cagtttaaat tggttcaggg tgataactac ttagcactgc   1560

cctggtgatt acccagagat atctatgaaa accagtggct tccatcaaac ctttgccaac   1620

tcaggttcac agcagctttg ggcagttatg gcagtatggc attagctgag aggtgtctgc   1680

cacttctggg tcaatggaat aataaattaa gtacaggcag gaatttggtt gggagcatct   1740

tgtatgatct ccgtatgatg tgatattgat ggagatagtg gtcctcattc ttgggggttg   1800

ccattcccac attccccctt caacaaacag tgtaacaggt ccttcccaga tttagggtac   1860

ttttattgat ggatatgttt tccttttatt cacataaccc cttgaaaccc tgtcttgtcc   1920

tcctgttact tgcttctgct gtacaagatg tagcaccttt tctcctcttt gaacatggtc   1980

tagtgacacg gtagcaccag ttgcaggaag gagccagact tgttctcaga gcactgtgtt   2040

cacacttttc agcaaaaata gctatggttg taacatatgt attcccttcc tctgatttga   2100

aggcaaaaat ctacagtgtt tcttcacttc ttttctgatc tggggcatga aaaaagcaag   2160

attgaaattt gaactatgag tctcctgcat ggcaacaaaa tgtgtgtcac catcaggcca   2220

acaggccagc ccttgaatgg ggatttatta ctgttgtatc tatgttgcat gataaacatt   2280

catcaccttc ctcctgtagt cctgcctcgt actccccttc ccctatgatt gaaaagtaaa   2340

caaaacccac atttcctatc ctggttagaa gaaaattaat gttctgacag ttgtgatcgc   2400

ctggagtact tttagacttt tagcattcgt tttttacctg tttgtggatg tgtgtttgta   2460

tgtgcatacg tatgagatag gcacatgcat cttctgtatg gacaaaggtg gggtacctac   2520

aggagagcaa aggttaattt tgtgctttta gtaaaaacat ttaaatacaa agttctttat   2580

tgggtggaat tatatttgat gcaaatattt gatcacttaa aacttttaaa acttctaggt   2640

aatttgccac gctttttgac tgctcaccaa taccctgtaa aaatacgtaa ttcttcctgt   2700

ttgtgtaata agatattcat atttgtagtt gcattaataa tagttatttc ttagtccatc   2760

agatgttccc gtgtgcctct tttatgccaa attgattgtc atatttcatg ttgggaccaa   2820

gtagtttgcc catggcaaac ctaaatttat gacctgctga ggcctctcag aaaactgagc   2880

atactagcaa gacagctctt cttgaaaaaa aaaatatgta tacacaaata tatacgtata   2940

tctatatata cgtatgtata tacacacatg tatattcttc cttgattgtg tagctgtcca   3000

aaataataac atatatagag ggagctgtat tcctttatac aaatctgatg gctcctgcag   3060

cactttttcc ttctgaaaat atttacattt tgctaaccta gtttgttact ttaaaaatca   3120

gttttgatga aaggagggaa aagcagatgg acttgaaaaa gatccaagct cctattagaa   3180

aaggtatgaa aatctttata gtaaaatttt ttataaacta aagttgtacc ttttaatatg   3240

tagtaaactc tcatttattt ggggttcgct cttggatctc atccatccat tgtgttctct   3300

ttaatgctgc ctgccttttg aggcattcac tgccctagac aatgccacca gagatagtgg   3360

gggaaatgcc agatgaaacc aactcttgct ctcactagtt gtcagcttct ctggataagt   3420

gaccacagaa gcaggagtcc tcctgcttgg gcatcattgg gccagttcct tctctttaaa   3480

tcagatttgt aatggctccc aaattccatc acatcacatt taaattgcag acagtgtttt   3540

gcacatcatg tatctgtttt gtcccataat atgcttttta ctccctgatc ccagtttctg   3600

ctgttgactc ttccattcag ttttatttat tgtgtgttct cacagtgaca ccatttgtcc   3660

ttttctgcaa caacctttcc agctactttt gccaaattct atttgtcttc tccttcaaaa   3720

cattctcctt tgcagttcct cttcatctgt gtagctgctc ttttgtctct taacttacca   3780

ttcctatagt actttatgca tctctgctta gttctattag ttttttggcc ttgctcttct   3840

ccttgatttt aaaattcctt ctatagctag agcttttctt tctttcattc tctcttcctg   3900

cagtgttttg catacatcag aagctaggta cataagttaa atgattgaga gttggctgta   3960

tttagattta tcacttttta atagggtgag cttgagagtt ttctttcttt ctgttttttt   4020

tttttgtttt tttttttttt tttttttttt ttttttttga ctaatttcac atgctctaaa   4080

aaccttcaaa ggtgattatt tttctcctgg aaactccagg tccattctgt ttaaatccct   4140

aagaatgtca gaattaaaat aacagggcta tcccgtaatt ggaaatattt cttttttcag   4200

gatgctatag tcaatttagt aagtgaccac caaattgtta tttgcactaa caaagctcaa   4260

aacacgataa gtttactcct ccatctcagt aataaaaatt aagctgtaat caaccttcta   4320

ggtttctctt gtcttaaaat gggtattcaa aaatggggat ctgtggtgta tgtatggaaa   4380

cacatactcc ttaatttacc tgttgttgga aactggagaa atgattgtcg ggcaaccgtt   4440

tattttttat tgtattttat ttggttgagg gattttttta taaacagttt tacttgtgtc   4500

atattttaaa attactaact gccatcacct gctggggtcc tttgttaggt cattttcagt   4560

gactaatagg gataatccag gtaactttga agagatgagc agtgagtgac caggcagttt   4620

ttctgccttt agctttgaca gttcttaatt aagatcattg aagaccagct ttctcataaa   4680

tttctctttt tgaaaaaaag aaagcatttg tactaagctc ctctgtaaga caacatctta   4740

aatcttaaaa gtgttgttat catgactggt gagagaagaa aacattttgt ttttattaaa   4800

tggagcatta tttacaaaaa gccattgttg agaattagat cccacatcgt ataaatatct   4860

attaaccatt ctaaataaag agaactccag tgttgctatg tgcaagatcc tctcttggag   4920

cttttttgca tagcaattaa aggtgtgcta tttgtcagta gccatttttt tgcagtgatt   4980

tgaagaccaa agttgtttta cagctgtgtt accgttaaag gttttttttt ttatatgtat   5040

taaatcaatt tatcactgtt taaagctttg aatatctgca atctttgcca aggtactttt   5100

ttatttaaaa aaaaacataa ctttgtaaat attaccctgt aatattatat atacttaata   5160

aaacatttta agctat                                                   5176


<210>  1675
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  1675


Met Trp Pro Leu Val Ala Ala Leu Leu Leu Gly Ser Ala Cys Cys Gly 
1               5                   10                  15      


Ser Ala Gln Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe 
            20                  25                  30          


Cys Asn Asp Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala 
        35                  40                  45              


Gln Asn Thr Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp 
    50                  55                  60                  


Ile Tyr Thr Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp 
65                  70                  75                  80  


Phe Ser Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala 
                85                  90                  95      


Ser Leu Lys Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr 
            100                 105                 110         


Thr Cys Glu Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu 
        115                 120                 125             


Leu Lys Tyr Arg Val Val Ser Trp Phe Ser Pro Asn Glu Asn Ile Leu 
    130                 135                 140                 


Ile Val Ile Phe Pro Ile Phe Ala Ile Leu Leu Phe Trp Gly Gln Phe 
145                 150                 155                 160 


Gly Ile Lys Thr Leu Lys Tyr Arg Ser Gly Gly Met Asp Glu Lys Thr 
                165                 170                 175     


Ile Ala Leu Leu Val Ala Gly Leu Val Ile Thr Val Ile Val Ile Val 
            180                 185                 190         


Gly Ala Ile Leu Phe Val Pro Gly Glu Tyr Ser Leu Lys Asn Ala Thr 
        195                 200                 205             


Gly Leu Gly Leu Ile Val Thr Ser Thr Gly Ile Leu Ile Leu Leu His 
    210                 215                 220                 


Tyr Tyr Val Phe Ser Thr Ala Ile Gly Leu Thr Ser Phe Val Ile Ala 
225                 230                 235                 240 


Ile Leu Val Ile Gln Val Ile Ala Tyr Ile Leu Ala Val Val Gly Leu 
                245                 250                 255     


Ser Leu Cys Ile Ala Ala Cys Ile Pro Met His Gly Pro Leu Leu Ile 
            260                 265                 270         


Ser Gly Leu Ser Ile Leu Ala Leu Ala Gln Leu Leu Gly Leu Val Tyr 
        275                 280                 285             


Met Lys Phe Val Ala Ser Asn Gln Lys Thr Ile Gln Pro Pro Arg Lys 
    290                 295                 300                 


Ala Val Glu Glu Pro Leu Asn Ala Phe Lys Glu Ser Lys Gly Met Met 
305                 310                 315                 320 


Asn Asp Glu 
            

<210>  1676
<211>  785
<212>  DNA
<213>  Homo sapiens

<400>  1676
gacagagtga gactctgtct caaaaaaaat aaaaaagaat tatgaatatt acttttataa     60

tattctcacc actgggaaaa atgcactatt ctgtgtctaa gtagctgctt accttaacca    120

agtgatattt gggcaagggg atcgttgcct tttgctactg gttgagacga agcatggcac    180

cccctagtag agaaggatcc caattacttc caatttgtga tgtacacatt ttagaaagat    240

acaggctatt gccacagaga tagaccaaaa catctcattt tctttctttg taaacctaga    300

tctgatttcc caactaagtc tgtttccttt gtgaatgctg tgggtatgat ccacagaaag    360

gctacataat gaaatgatag ctttacaatt aatttggctg tagagttgta gactagttag    420

catatcattg catatttgtt tatttagaaa tgatttccaa ttgtggaacc tcactaactg    480

cctgcttggc ttgttactaa tcctagcatt caaagaatca aaaggaatga tgaatgatga    540

ataactgaag tgaagtgatg gactccgatt tggagagtag taagacgtga aaggaataca    600

cttgtgttta agcaccatgg ccttgatgat tcactgttgg ggagaagaaa caagaaaagt    660

aactggttgt cacctatgag acccttacgt gattgttagt taagttttta ttcaaagcag    720

ctgtaattta gttaataaaa taattatgat ctatgttgtt tgcccaattg agatccagtt    780

ttttg                                                                785


<210>  1677
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  1677


Cys Thr His Phe Arg Lys Ile Gln Ala Ile Ala Thr Glu Ile Asp Gln 
1               5                   10                  15      


Asn Ile Ser Phe Ser Phe Phe Val Asn Leu Asp Leu Ile Ser Gln Leu 
            20                  25                  30          


Ser Leu Phe Pro Leu 
        35          

<210>  1678
<211>  873
<212>  DNA
<213>  Homo sapiens

<400>  1678
gaaaaaggca actcagaaag ctaagaagaa atagatagag gaatactcag agctatctga     60

gtattttctt tagtttgtta gctctttgga gctttgaaac tggaaagacc cagggagtga    120

tgtggagaaa gagactgagc ttgtaagaca caggagcagt gagctaaggg agatggagta    180

gtggggacaa attctggcac attctgtcta cactctgggt agatagagga gggaggatgg    240

agcacccatg gtgggggtat gttggtgaca gcattttccc accagccagt gtaacaagtg    300

gctgatttgg gggaaagatg gcataaacaa atgagagaat gtgtttacta tttgatgtag    360

atgggttatt tgcttcattt ttcaaatcag tgtatataat caagaatatt cagcatgttt    420

gaatagactg tcagagctgg aactctttca ttaacatctc tggcaccttt agttttagcc    480

ctgaacattt tatcttaaaa ttaaacatta ccaaatgcct tagtttattt catttattaa    540

atttatattc ttatttgtta tttatatcag cttccaatca gaagactata caacctccta    600

ggaaagctgt agaggaaccc cttaatgaat aactgaagtg aagtgatgga ctccgatttg    660

gagagtagta agacgtgaaa ggaatacact tgtgtttaag caccatggcc ttgatgattc    720

actgttgggg agaagaaaca agaaaagtaa ctggttgtca cctatgagac ccttacgtga    780

ttgttagtta agtttttatt caaagcagct gtaatttagt taataaaata attatgatct    840

atgttgtttg cccaattgag atccagtttt ttg                                 873


<210>  1679
<211>  69
<212>  PRT
<213>  Homo sapiens

<400>  1679


Ile Asp Cys Gln Ser Trp Asn Ser Phe Ile Asn Ile Ser Gly Thr Phe 
1               5                   10                  15      


Ser Phe Ser Pro Glu His Phe Ile Leu Lys Leu Asn Ile Thr Lys Cys 
            20                  25                  30          


Leu Ser Leu Phe His Leu Leu Asn Leu Tyr Ser Tyr Leu Leu Phe Ile 
        35                  40                  45              


Ser Ala Ser Asn Gln Lys Thr Ile Gln Pro Pro Arg Lys Ala Val Glu 
    50                  55                  60                  


Glu Pro Leu Asn Glu 
65                  

<210>  1680
<211>  989
<212>  DNA
<213>  Homo sapiens

<400>  1680
ctagggtatt ctttttccct ttcgtcactt tgctcatgta ctgtattcct tcaacttcat     60

taatgaatcc atttggaagc agtgaaaaag gcaactcaga aagctaagaa gaaatagata    120

gaggaatact cagagctatc tgagtatttt ctttagtttg ttagctcttt ggagctttga    180

aactggaaag acccagggag tgatgtggag aaagagactg agcttgtaag acacaggagc    240

agtgagctaa gggagatgga gtagtgggga caaattctgg cacattctgt ctacactctg    300

ggtagataga ggagggagga tggagcaccc atggtggggg tatgttggtg acagcatttt    360

cccaccagcc agtgtaacaa gtggctgatt tgggggaaag atggcataaa caaatgagag    420

aatgtgttta ctatttgatg tagatgggtt atttgcttca tttttcaaat cagtgtatat    480

aatcaagaat attcagcatg tttgaataga ctgtcagagc tggaactctt tcattaacat    540

ctctggcacc tttagtttta gccctgaaca ttttatctta aaattaaaca ttaccaaatg    600

ccttagttta tttcatttat taaatttata ttcttatttg ttatttatat cagcttccaa    660

tcagaagact atacaacctc ctaggaaagc tgtagaggaa ccccttaatg cattcaaaga    720

atcaaaagga atgatgaatg atgaataact gaagtgaagt gatggactcc gatttggaga    780

gtagtaagac gtgaaaggaa tacacttgtg tttaagcacc atggccttga tgattcactg    840

ttggggagaa gaaacaagaa aagtaactgg ttgtcaccta tgagaccctt acgtgattgt    900

tagttaagtt tttattcaaa gcagctgtaa tttagttaat aaaataatta tgatctatgt    960

tgtttgccca attgagatcc agttttttg                                      989


<210>  1681
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  1681


Cys Arg Trp Val Ile Cys Phe Ile Phe Gln Ile Ser Val Tyr Asn Gln 
1               5                   10                  15      


Glu Tyr Ser Ala Cys Leu Asn Arg Leu Ser Glu Leu Glu Leu Phe His 
            20                  25                  30          

<210>  1682
<211>  565
<212>  DNA
<213>  Homo sapiens

<400>  1682
gcagaaatcg taataattct tttgtcacat gggttatatc catattggag agaattaact     60

caggtgaaat taacttgtac actgtttggt tttataatat ttagagggat cacaactgac    120

tgatgtccct ttgaagtacc attcttcata aatctttttt tttcagaatg ggccagccaa    180

ctgtgacatc ccttggatcg gagatttaga actagaaagt attctttcta cattattagg    240

gaagaaaagg agttacttgg cgcttccaat cagaagacta tacaacctcc taggaaagct    300

gtagaggaac cccttaatga ataactgaag tgaagtgatg gactccgatt tggagagtag    360

taagacgtga aaggaataca cttgtgttta agcaccatgg ccttgatgat tcactgttgg    420

ggagaagaaa caagaaaagt aactggttgt cacctatgag acccttacgt gattgttagt    480

taagttttta ttcaaagcag ctgtaattta gttaataaaa taattatgat ctatgttgtt    540

tgcccaattg agatccagtt ttttg                                          565


<210>  1683
<211>  50
<212>  PRT
<213>  Homo sapiens

<400>  1683


Ile Phe Phe Phe Gln Asn Gly Pro Ala Asn Cys Asp Ile Pro Trp Ile 
1               5                   10                  15      


Gly Asp Leu Glu Leu Glu Ser Ile Leu Ser Thr Leu Leu Gly Lys Lys 
            20                  25                  30          


Arg Ser Tyr Leu Ala Leu Pro Ile Arg Arg Leu Tyr Asn Leu Leu Gly 
        35                  40                  45              


Lys Leu 
    50  

<210>  1684
<211>  3558
<212>  DNA
<213>  Homo sapiens

<400>  1684
aagaagttaa tgtcgctatg agatttttaa cttttataat ttttattatt tccaacttta     60

aatttgtagc cttaatttgc tattttaaag agtaggcctt tcactttcta caactttctg    120

tgaaagtgac tttcactttc tattttttaa ctttttaaac tgtgttgtat tttttttctt    180

ttattggaag cattttaatt ttataagatg agaaaaagga ctgggcacaa taacttaatg    240

tgaaagcata gaaaagatta caagaaccta accaaactca ctaaagttgg gcttgttgtt    300

tgtagagaac gtttatataa ttataaggat caatactttc tcatttttaa agccattacc    360

agttagttca atataagggc atatagtgtt ttgatacaaa tcaatctggt agcagtaagt    420

accatattta ccacaacatc ccagatattt tagaatgatg cagatgcaga atatatacgt    480

agaatttata tctatgtata gatacaaatt cagatatttt cttgttcaat ttaaggagag    540

gtaaatttgg tatcaataga aaaaatgttt ctgaaaaatt taaaccctgg aaatgtattt    600

atggcatgga gtcagatgtt tcagggagag aagaacaaat caagaagcat tgcaagtatg    660

ctcatatgga atgcttaagg cttgtggtta aaaaatatat atatatggct gtcaatgtct    720

taggctcatg gtagcagcag aaatcgtaat aattcttttg tcacatgggt tatatccata    780

ttggagagaa ttaactcagg tgaaattaac ttgtacactg tttggtttta taatatttag    840

agggatcaca actgactgat gtccctttga agtaccattc ttcataaatc tttttttttc    900

agaatgggcc agccaactgt gacatccctt ggatcggaga tttagaacta gaaagtattc    960

tttctacatt attagggaag aaaaggagtt acttggcggt tagcaatatt ctattttgtt   1020

ttgttttgtt tttagagaca gggtctcatt atgttgacca ggctggcctc gagctcctgg   1080

gctcaagcaa tgctcccacc tcagcctccc aagtagctgg gactacaggc atgtgccact   1140

acacctggca gtgtttattc tgataaatac atttatgagc tcaaaaatgt aactctaaaa   1200

ccttatctct gaacttccat attaccatca gaaatttaga tagttgttta gttctctttt   1260

tctttgtaga acatagatat aaggcatggt ttcattgaag tcagttgtat atacatgtaa   1320

ctatcctgat gttcccaaat aaagctctgt atttctgctt agtttattgg ggaggctgct   1380

aaatgtagtg catcccaacc cattttaccc tgttctactt taaaaagagg ttggcttctt   1440

gtttggatac aaggaccaag tcactccccc aggttcctcc acagtaaggg aggcctattt   1500

aaagccgccc atggcactaa cagaaactgg actcctatga gctcagatac ataactgggc   1560

ctcacagggg tgggacagta tgtagtctag gaattggaag gatccattcc atatcaaaga   1620

actgaagcat cgtgttgccc tctcagcagc aagagtaagg tgatgcccct gtcagttata   1680

gttcctgagt tcctctgtct ttgattcttt gcctattagc cagctagctc accctcttgt   1740

ttatgccact gttttttatc ctattcatgc cttctcacag acaacttttc ttacctacag   1800

ctttggactc atccttgtct cctttctgtt tctttttcac tttcccttcc catcaccaac   1860

tttctgggtt tttttctgtt tcttcttaga gtccagtggc agggagaaac ttgtcagtcc   1920

agtctgttgc catttttcct gtttgagaaa gactcaccag cttttggctg gctcacagat   1980

tggctttcct tgggtcagga cccacccttt tccctgccag ctttggaagc ttgacagaat   2040

tcgagtgtgc agtggtggta aataaatagt aaggaacaca gagcagtcct ggaggcgtgc   2100

ctccatctgc tgatgagaaa atccagtgct gtcatccagc ccaggtccca gcggaatggg   2160

cctctctgtt cagtaggatc cccctcctgc tgagtggttc atggcatgtt tctgttcaac   2220

gcttttccat ctgtaggatt cttattctgt atttatttgt ttttttgggt ttttttattt   2280

tttgagatgg agtctcgctc tgtcgcccag gctggagtgc agtggcacga ccccagctcg   2340

ctgcagcctc tgcctcccag gacgagggag atcctcccac ctcagccttc cacgtagctg   2400

ggactacagg catgcaccac aggcatgcac caccacgcca gctaattttt gtatttttgg   2460

tagagacagg gttgcatcat gttgcccagg ctggtcttga atgcctgagc tcaagcaatc   2520

tatttgcctt ggcctcccaa agtgctggga ttacaggcat gagccaccac ggccagcctt   2580

ctcatttgtt ttttttataa ggaagctatc tcttcttccc tccccaacta gggtattctt   2640

tttccctttc gtcactttgc tcatgtactg tattccttca acttcattaa tgaatccatt   2700

tggaagcagt gaaaaaggca actcagaaag ctaagaagaa atagatagag gaatactcag   2760

agctatctga gtattttctt tagtttgtta gctctttgga gctttgaaac tggaaagacc   2820

cagggagtga tgtggagaaa gagactgagc ttgtaagaca caggagcagt gagctaaggg   2880

agatggagta gtggggacaa attctggcac attctgtcta cactctgggt agatagagga   2940

gggaggatgg agcacccatg gtgggggtat gttggtgaca gcattttccc accagccagt   3000

gtaacaagtg gctgatttgg gggaaagatg gcataaacaa atgagagaat gtgtttacta   3060

tttgatgtag atgggttatt tgcttcattt ttcaaatcag tgtatataat caagaatatt   3120

cagcatgttt gaatagactg tcagagctgg aactctttca ttaacatctc tggcaccttt   3180

agttttagcc ctgaacattt tatcttaaaa ttaaacatta ccaaatgcct tagtttattt   3240

catttattaa atttatattc ttatttgtta tttatatcag cttccaatca gaagactata   3300

caacctccta ggaataactg aagtgaagtg atggactccg atttggagag tagtaagacg   3360

tgaaaggaat acacttgtgt ttaagcacca tggccttgat gattcactgt tggggagaag   3420

aaacaagaaa agtaactggt tgtcacctat gagaccctta cgtgattgtt agttaagttt   3480

ttattcaaag cagctgtaat ttagttaata aaataattat gatctatgtt gtttgcccaa   3540

ttgagatcca gttttttg                                                 3558


<210>  1685
<211>  77
<212>  PRT
<213>  Homo sapiens

<400>  1685


Met Pro Glu Leu Lys Gln Ser Ile Cys Leu Gly Leu Pro Lys Cys Trp 
1               5                   10                  15      


Asp Tyr Arg His Glu Pro Pro Arg Pro Ala Phe Ser Phe Val Phe Phe 
            20                  25                  30          


Ile Arg Lys Leu Ser Leu Leu Pro Ser Pro Thr Arg Val Phe Phe Phe 
        35                  40                  45              


Pro Phe Val Thr Leu Leu Met Tyr Cys Ile Pro Ser Thr Ser Leu Met 
    50                  55                  60                  


Asn Pro Phe Gly Ser Ser Glu Lys Gly Asn Ser Glu Ser 
65                  70                  75          

<210>  1686
<211>  1317
<212>  DNA
<213>  Homo sapiens

<400>  1686
cggctctcgc gggcggggag caggcggggg agcgggcggg aagcagtggg agcgcgcgtg     60

cgcgcggccg tgcagcctgg gcagtgggtc ctgcctgtga cgcgcggcgg cggtcggtcc    120

tgcctgtaac ggcggcggcg gctgctgctc cggacacctg cggcggcggc ggcgaccccg    180

cggcgggcgc ggagatgtgg cccctggtag cggcgctgtt gctgggctcg gcgtgctgcg    240

gatcagctca gctactattt aataaaacaa aatctgtaga attcacgttt tgtaatgaca    300

ctgtcgtcat tccatgcttt gttactaata tggaggcaca aaacactact gaagtatacg    360

taaagtggaa atttaaagga agagatattt acacctttga tggagctcta aacaagtcca    420

ctgtccccac tgactttagt agtgcaaaaa ttgaagtctc acaattacta aaaggagatg    480

cctctttgaa gatggataag agtgatgctg tctcacacac aggaaactac acttgtgaag    540

taacagaatt aaccagagaa ggtgaaacga tcatcgagct aaaatatcgt gttgtttcat    600

ggttttctcc aaatgaaaat attcttattg ttattttccc aatttttgct atactcctgt    660

tctggggaca gtttggtatt aaaacactta aatatagatc cggtggtatg gatgagaaaa    720

caattgcttt acttgttgct ggactagtga tcactgtcat tgtcattgtt ggagccattc    780

ttttcgtccc aggtgaatat tcattaaaga atgctactgg ccttggttta attgtgactt    840

ctacagggat attaatatta cttcactact atgtgtttag tacagcgatt ggattaacct    900

ccttcgtcat tgccatattg gttattcagg tgatagccta tatcctcgct gtggttggac    960

tgagtctctg tattgcggcg tgtataccaa tgcatggccc tcttctgatt tcaggtttga   1020

gtatcttagc tctagcacaa ttacttggac tagtttatat gaaatttgtg gaataactga   1080

agtgaagtga tggactccga tttggagagt agtaagacgt gaaaggaata cacttgtgtt   1140

taagcaccat ggccttgatg attcactgtt ggggagaaga aacaagaaaa gtaactggtt   1200

gtcacctatg agacccttac gtgattgtta gttaagtttt tattcaaagc agctgtaatt   1260

tagttaataa aataattatg atctatgttg tttgcccaat tgagatccag ttttttg      1317


<210>  1687
<211>  293
<212>  PRT
<213>  Homo sapiens

<400>  1687


Met Trp Pro Leu Val Ala Ala Leu Leu Leu Gly Ser Ala Cys Cys Gly 
1               5                   10                  15      


Ser Ala Gln Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe 
            20                  25                  30          


Cys Asn Asp Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala 
        35                  40                  45              


Gln Asn Thr Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp 
    50                  55                  60                  


Ile Tyr Thr Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp 
65                  70                  75                  80  


Phe Ser Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala 
                85                  90                  95      


Ser Leu Lys Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr 
            100                 105                 110         


Thr Cys Glu Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu 
        115                 120                 125             


Leu Lys Tyr Arg Val Val Ser Trp Phe Ser Pro Asn Glu Asn Ile Leu 
    130                 135                 140                 


Ile Val Ile Phe Pro Ile Phe Ala Ile Leu Leu Phe Trp Gly Gln Phe 
145                 150                 155                 160 


Gly Ile Lys Thr Leu Lys Tyr Arg Ser Gly Gly Met Asp Glu Lys Thr 
                165                 170                 175     


Ile Ala Leu Leu Val Ala Gly Leu Val Ile Thr Val Ile Val Ile Val 
            180                 185                 190         


Gly Ala Ile Leu Phe Val Pro Gly Glu Tyr Ser Leu Lys Asn Ala Thr 
        195                 200                 205             


Gly Leu Gly Leu Ile Val Thr Ser Thr Gly Ile Leu Ile Leu Leu His 
    210                 215                 220                 


Tyr Tyr Val Phe Ser Thr Ala Ile Gly Leu Thr Ser Phe Val Ile Ala 
225                 230                 235                 240 


Ile Leu Val Ile Gln Val Ile Ala Tyr Ile Leu Ala Val Val Gly Leu 
                245                 250                 255     


Ser Leu Cys Ile Ala Ala Cys Ile Pro Met His Gly Pro Leu Leu Ile 
            260                 265                 270         


Ser Gly Leu Ser Ile Leu Ala Leu Ala Gln Leu Leu Gly Leu Val Tyr 
        275                 280                 285             


Met Lys Phe Val Glu 
    290             

<210>  1688
<211>  1349
<212>  DNA
<213>  Homo sapiens

<400>  1688
cggctctcgc gggcggggag caggcggggg agcgggcggg aagcagtggg agcgcgcgtg     60

cgcgcggccg tgcagcctgg gcagtgggtc ctgcctgtga cgcgcggcgg cggtcggtcc    120

tgcctgtaac ggcggcggcg gctgctgctc cggacacctg cggcggcggc ggcgaccccg    180

cggcgggcgc ggagatgtgg cccctggtag cggcgctgtt gctgggctcg gcgtgctgcg    240

gatcagctca gctactattt aataaaacaa aatctgtaga attcacgttt tgtaatgaca    300

ctgtcgtcat tccatgcttt gttactaata tggaggcaca aaacactact gaagtatacg    360

taaagtggaa atttaaagga agagatattt acacctttga tggagctcta aacaagtcca    420

ctgtccccac tgactttagt agtgcaaaaa ttgaagtctc acaattacta aaaggagatg    480

cctctttgaa gatggataag agtgatgctg tctcacacac aggaaactac acttgtgaag    540

taacagaatt aaccagagaa ggtgaaacga tcatcgagct aaaatatcgt gttgtttcat    600

ggttttctcc aaatgaaaat attcttattg ttattttccc aatttttgct atactcctgt    660

tctggggaca gtttggtatt aaaacactta aatatagatc cggtggtatg gatgagaaaa    720

caattgcttt acttgttgct ggactagtga tcactgtcat tgtcattgtt ggagccattc    780

ttttcgtccc aggtgaatat tcattaaaga atgctactgg ccttggttta attgtgactt    840

ctacagggat attaatatta cttcactact atgtgtttag tacagcgatt ggattaacct    900

ccttcgtcat tgccatattg gttattcagg tgatagccta tatcctcgct gtggttggac    960

tgagtctctg tattgcggcg tgtataccaa tgcatggccc tcttctgatt tcaggtttga   1020

gtatcttagc tctagcacaa ttacttggac tagtttatat gaaatttgtg gcttccaatc   1080

agaagactat acaacctcct aggaataact gaagtgaagt gatggactcc gatttggaga   1140

gtagtaagac gtgaaaggaa tacacttgtg tttaagcacc atggccttga tgattcactg   1200

ttggggagaa gaaacaagaa aagtaactgg ttgtcaccta tgagaccctt acgtgattgt   1260

tagttaagtt tttattcaaa gcagctgtaa tttagttaat aaaataatta tgatctatgt   1320

tgtttgccca attgagatcc agttttttg                                     1349


<210>  1689
<211>  305
<212>  PRT
<213>  Homo sapiens

<400>  1689


Met Trp Pro Leu Val Ala Ala Leu Leu Leu Gly Ser Ala Cys Cys Gly 
1               5                   10                  15      


Ser Ala Gln Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe 
            20                  25                  30          


Cys Asn Asp Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala 
        35                  40                  45              


Gln Asn Thr Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp 
    50                  55                  60                  


Ile Tyr Thr Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp 
65                  70                  75                  80  


Phe Ser Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala 
                85                  90                  95      


Ser Leu Lys Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr 
            100                 105                 110         


Thr Cys Glu Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu 
        115                 120                 125             


Leu Lys Tyr Arg Val Val Ser Trp Phe Ser Pro Asn Glu Asn Ile Leu 
    130                 135                 140                 


Ile Val Ile Phe Pro Ile Phe Ala Ile Leu Leu Phe Trp Gly Gln Phe 
145                 150                 155                 160 


Gly Ile Lys Thr Leu Lys Tyr Arg Ser Gly Gly Met Asp Glu Lys Thr 
                165                 170                 175     


Ile Ala Leu Leu Val Ala Gly Leu Val Ile Thr Val Ile Val Ile Val 
            180                 185                 190         


Gly Ala Ile Leu Phe Val Pro Gly Glu Tyr Ser Leu Lys Asn Ala Thr 
        195                 200                 205             


Gly Leu Gly Leu Ile Val Thr Ser Thr Gly Ile Leu Ile Leu Leu His 
    210                 215                 220                 


Tyr Tyr Val Phe Ser Thr Ala Ile Gly Leu Thr Ser Phe Val Ile Ala 
225                 230                 235                 240 


Ile Leu Val Ile Gln Val Ile Ala Tyr Ile Leu Ala Val Val Gly Leu 
                245                 250                 255     


Ser Leu Cys Ile Ala Ala Cys Ile Pro Met His Gly Pro Leu Leu Ile 
            260                 265                 270         


Ser Gly Leu Ser Ile Leu Ala Leu Ala Gln Leu Leu Gly Leu Val Tyr 
        275                 280                 285             


Met Lys Phe Val Ala Ser Asn Gln Lys Thr Ile Gln Pro Pro Arg Asn 
    290                 295                 300                 


Asn 
305 

<210>  1690
<211>  1427
<212>  DNA
<213>  Homo sapiens

<400>  1690
cggggccgag tgcgcgtgcg cggctctcgc gggcggggag caggcggggg agcgggcggg     60

aagcagtggg agcgcgcgtg cgcgcggccg tgcagcctgg gcagtgggtc ctgcctgtga    120

cgcgcggcgg cggtcggtcc tgcctgtaac ggcggcggcg gctgctgctc cggacacctg    180

cggcggcggc ggcgaccccg cggcgggcgc ggagatgtgg cccctggtag cggcgctgtt    240

gctgggctcg gcgtgctgcg gatcagctca gctactattt aataaaacaa aatctgtaga    300

attcacgttt tgtaatgaca ctgtcgtcat tccatgcttt gttactaata tggaggcaca    360

aaacactact gaagtatacg taaagtggaa atttaaagga agagatattt acacctttga    420

tggagctcta aacaagtcca ctgtccccac tgactttagt agtgcaaaaa ttgaagtctc    480

acaattacta aaaggagatg cctctttgaa gatggataag agtgatgctg tctcacacac    540

aggaaactac acttgtgaag taacagaatt aaccagagaa ggtgaaacga tcatcgagct    600

aaaatatcgt gttgtttcat ggttttctcc aaatgaaaat attcttattg ttattttccc    660

aatttttgct atactcctgt tctggggaca gtttggtatt aaaacactta aatatagatc    720

cggtggtatg gatgagaaaa caattgcttt acttgttgct ggactagtga tcactgtcat    780

tgtcattgtt ggagccattc ttttcgtccc aggtgaatat tcattaaaga atgctactgg    840

ccttggttta attgtgactt ctacagggat attaatatta cttcactact atgtgtttag    900

tacagcgatt ggattaacct ccttcgtcat tgccatattg gttattcagg tgatagccta    960

tatcctcgct gtggttggac tgagtctctg tattgcggcg tgtataccaa tgcatggccc   1020

tcttctgatt tcaggtttga gtatcttagc tctagcacaa ttacttggac tagtttatat   1080

gaaatttgtg gcttccaatc agaagactat acaacctcct aggaaagctg tagaggaacc   1140

ccttaatgca ttcaaagaat caaaaggaat gatgaatgat gaataactga agtgaagtga   1200

tggactccga tttggagagt agtaagacgt gaaaggaata cacttgtgtt taagcaccat   1260

ggccttgatg attcactgtt ggggagaaga aacaagaaaa gtaactggtt gtcacctatg   1320

agacccttac gtgattgtta gttaagtttt tattcaaagc agctgtaatt tagttaataa   1380

aataattatg atctatgttg tttgcccaat tgagatccag ttttttg                 1427


<210>  1691
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  1691


Met Trp Pro Leu Val Ala Ala Leu Leu Leu Gly Ser Ala Cys Cys Gly 
1               5                   10                  15      


Ser Ala Gln Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe 
            20                  25                  30          


Cys Asn Asp Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala 
        35                  40                  45              


Gln Asn Thr Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp 
    50                  55                  60                  


Ile Tyr Thr Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp 
65                  70                  75                  80  


Phe Ser Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala 
                85                  90                  95      


Ser Leu Lys Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr 
            100                 105                 110         


Thr Cys Glu Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu 
        115                 120                 125             


Leu Lys Tyr Arg Val Val Ser Trp Phe Ser Pro Asn Glu Asn Ile Leu 
    130                 135                 140                 


Ile Val Ile Phe Pro Ile Phe Ala Ile Leu Leu Phe Trp Gly Gln Phe 
145                 150                 155                 160 


Gly Ile Lys Thr Leu Lys Tyr Arg Ser Gly Gly Met Asp Glu Lys Thr 
                165                 170                 175     


Ile Ala Leu Leu Val Ala Gly Leu Val Ile Thr Val Ile Val Ile Val 
            180                 185                 190         


Gly Ala Ile Leu Phe Val Pro Gly Glu Tyr Ser Leu Lys Asn Ala Thr 
        195                 200                 205             


Gly Leu Gly Leu Ile Val Thr Ser Thr Gly Ile Leu Ile Leu Leu His 
    210                 215                 220                 


Tyr Tyr Val Phe Ser Thr Ala Ile Gly Leu Thr Ser Phe Val Ile Ala 
225                 230                 235                 240 


Ile Leu Val Ile Gln Val Ile Ala Tyr Ile Leu Ala Val Val Gly Leu 
                245                 250                 255     


Ser Leu Cys Ile Ala Ala Cys Ile Pro Met His Gly Pro Leu Leu Ile 
            260                 265                 270         


Ser Gly Leu Ser Ile Leu Ala Leu Ala Gln Leu Leu Gly Leu Val Tyr 
        275                 280                 285             


Met Lys Phe Val Ala Ser Asn Gln Lys Thr Ile Gln Pro Pro Arg Lys 
    290                 295                 300                 


Ala Val Glu Glu Pro Leu Asn Ala Phe Lys Glu Ser Lys Gly Met Met 
305                 310                 315                 320 


Asn Asp Glu 
            

<210>  1692
<211>  2050
<212>  DNA
<213>  Homo sapiens

<400>  1692
agttctcttc aagtcatgta atcgactttt ttgaattagt tttcagtttc attttgtttt     60

ccctaattca agttgggaac acttcatttt ccccaattca agttgggaac acttccttgg    120

tatttccttg ctacatggac tttagcaaat gctactttac tctccttttc ctagttttac    180

tgttggaagc ctaactcaca ggagagatta tgcaatacag tcctgaagtc aagggaggag    240

aggcatgact aatatgttct gcacaagaca tgaaggcaca gacagcactg tctttcttcc    300

tcattctcat aacatctctg agtggatctc aaggcatatt ccctttggct ttcttcattt    360

atgttcctat gaatgaacaa atcgtcattg gaagacttga tgaagatata attctccctt    420

cttcatttga gaggggatcc gaagtcgtaa tacactggaa gtatcaagat agctataagg    480

ttcacagtta ctacaaaggc agtgaccatt tggaaagcca agatcccaga tatgcaaaca    540

ggacatccct tttctataat gagattcaaa atgggaatgc gtcgctattt ttcagaagag    600

taagccttct ggacgaagga atttacacct gctatgtagg aacagcaatt caagtgatta    660

caaacaaagt ggtgctaaag gtgggagttt ttctcacacc cgtgatgaag tatgaaaaga    720

ggaacacaaa cagcttctta atatgcagcg tgttaagtgt ttatcctcgt ccaattatca    780

cgtggaaaat ggacaacaca cctatctctg aaaacaacat ggaagaaaca gggtctttgg    840

attctttttc tattaacagc ccactgaata ttacaggatc aaattcatct tatgaatgta    900

caattgaaaa ttcactgctg aagcaaacat ggacagggcg ctggacgatg aaagatggcc    960

ttcataaaat gcaaagtgaa cacgtttcac tctcatgtca acctgtaaat gattattttt   1020

caccaaacca agacttcaaa gttacttggt ccagaatgaa aagtgggact ttctctgtcc   1080

tggcttacta tctgagctcc tcacaaaata caattatcaa tgaatcccga ttctcatgga   1140

acaaagagct gataaaccag agtgacttct ctatgaattt gatggatctt aatctttcag   1200

acagtgggga atatttatgc aatatttctt cggatgaata tactttactt accatccaca   1260

cagtgcatgt agaaccgagc caagaaacag cttcccataa caaaggctta tggattttgg   1320

tgccctctgc gattttggca gcttttctgc tgatttggag cgtaaaatgt tgcagagaga   1380

aagatgttgt gtccctcctg gtgagcgctg tcccagtgca cccgataatg gcgaagaaaa   1440

tgtgcctctt tcaggaaaag tataggaaat gagagaagac tgtgacaact catgacctgc   1500

atccttaata tccagtgact tcatctcccc tttcttcacc acaattccag gcaatggcct   1560

gtcggagcag acaattctac cactgcaaag agttgtaacc attttctggt atcacattta   1620

tttttcaaga catacttttc aagacatcat tcactgaccc actacctgca ttgagtataa   1680

atgcctggat gttaaggatt ccaatttaac tttgaaaaga actgtctcat tcatttacat   1740

ttctgttaca gtcagcccag gaggttacag tgagctctcc actaagaatc tggaagaaat   1800

gcatcactag gggttgattc ccaatctgat caactgataa tgggtgagag agcaggtaag   1860

agccaaagtc accttagtgg aaaggttaaa aaccagagcc tggaaaccaa gatgattgat   1920

ttgacaaggt attttagtct agttttatat gaacggttgt atcagggtaa ccaactcgat   1980

ttgggatgaa tcttagggca ccaaagacta agacagtatc tttaagattg ctagggaaaa   2040

gggccctatg                                                          2050


<210>  1693
<211>  400
<212>  PRT
<213>  Homo sapiens

<400>  1693


Met Lys Ala Gln Thr Ala Leu Ser Phe Phe Leu Ile Leu Ile Thr Ser 
1               5                   10                  15      


Leu Ser Gly Ser Gln Gly Ile Phe Pro Leu Ala Phe Phe Ile Tyr Val 
            20                  25                  30          


Pro Met Asn Glu Gln Ile Val Ile Gly Arg Leu Asp Glu Asp Ile Ile 
        35                  40                  45              


Leu Pro Ser Ser Phe Glu Arg Gly Ser Glu Val Val Ile His Trp Lys 
    50                  55                  60                  


Tyr Gln Asp Ser Tyr Lys Val His Ser Tyr Tyr Lys Gly Ser Asp His 
65                  70                  75                  80  


Leu Glu Ser Gln Asp Pro Arg Tyr Ala Asn Arg Thr Ser Leu Phe Tyr 
                85                  90                  95      


Asn Glu Ile Gln Asn Gly Asn Ala Ser Leu Phe Phe Arg Arg Val Ser 
            100                 105                 110         


Leu Leu Asp Glu Gly Ile Tyr Thr Cys Tyr Val Gly Thr Ala Ile Gln 
        115                 120                 125             


Val Ile Thr Asn Lys Val Val Leu Lys Val Gly Val Phe Leu Thr Pro 
    130                 135                 140                 


Val Met Lys Tyr Glu Lys Arg Asn Thr Asn Ser Phe Leu Ile Cys Ser 
145                 150                 155                 160 


Val Leu Ser Val Tyr Pro Arg Pro Ile Ile Thr Trp Lys Met Asp Asn 
                165                 170                 175     


Thr Pro Ile Ser Glu Asn Asn Met Glu Glu Thr Gly Ser Leu Asp Ser 
            180                 185                 190         


Phe Ser Ile Asn Ser Pro Leu Asn Ile Thr Gly Ser Asn Ser Ser Tyr 
        195                 200                 205             


Glu Cys Thr Ile Glu Asn Ser Leu Leu Lys Gln Thr Trp Thr Gly Arg 
    210                 215                 220                 


Trp Thr Met Lys Asp Gly Leu His Lys Met Gln Ser Glu His Val Ser 
225                 230                 235                 240 


Leu Ser Cys Gln Pro Val Asn Asp Tyr Phe Ser Pro Asn Gln Asp Phe 
                245                 250                 255     


Lys Val Thr Trp Ser Arg Met Lys Ser Gly Thr Phe Ser Val Leu Ala 
            260                 265                 270         


Tyr Tyr Leu Ser Ser Ser Gln Asn Thr Ile Ile Asn Glu Ser Arg Phe 
        275                 280                 285             


Ser Trp Asn Lys Glu Leu Ile Asn Gln Ser Asp Phe Ser Met Asn Leu 
    290                 295                 300                 


Met Asp Leu Asn Leu Ser Asp Ser Gly Glu Tyr Leu Cys Asn Ile Ser 
305                 310                 315                 320 


Ser Asp Glu Tyr Thr Leu Leu Thr Ile His Thr Val His Val Glu Pro 
                325                 330                 335     


Ser Gln Glu Thr Ala Ser His Asn Lys Gly Leu Trp Ile Leu Val Pro 
            340                 345                 350         


Ser Ala Ile Leu Ala Ala Phe Leu Leu Ile Trp Ser Val Lys Cys Cys 
        355                 360                 365             


Arg Glu Lys Asp Val Val Ser Leu Leu Val Ser Ala Val Pro Val His 
    370                 375                 380                 


Pro Ile Met Ala Lys Lys Met Cys Leu Phe Gln Glu Lys Tyr Arg Lys 
385                 390                 395                 400 

<210>  1694
<211>  7074
<212>  DNA
<213>  Homo sapiens

<400>  1694
catttctact tcatatgatc attttaattg tatttacctc atcttaccaa aaagatcatg     60

gttgaatctt gcctactcac gtttagggcc tttttttggt ggattgcttt aataaagatg    120

gatctgtcag accttggaga agccgcagcc ttcctcagaa gaagtgaagc tgagctgctt    180

ctactacagg ccacagcctt ggatgggaag aagaaatgct ggattcctga tggtgagaat    240

gcttatatcg aggctgaggt aaaagggagt gaagatgatg gaacagtaat tgttgagaca    300

gcagatggag agagtctgag cataaaggag gacaaaatcc agcagatgaa tcctccagag    360

tttgaaatga ttgaagacat ggcaatgctg actcacctca atgaggcatc cgtgctgcat    420

accctgaagc ggcgctatgg ccagtggatg atctatacat attcaggtct cttctgtgtg    480

accataaacc cttacaaatg gcttcccgtg tatcagaaag aagtcatggc cgcctacaaa    540

gggaagaggc gatcagaggc tccccctcac atctttgctg ttgccaataa cgcctttcag    600

gacatgcttc acaatcgaga aaatcagtct atactcttca caggagaatc tggtgctgga    660

aagactgtga acagcaaaca tattatccag tattttgcca ccatagcagc catgattgaa    720

tccaggaaaa agcagggggc gttagaagat caaatcatgc aagcgaatac tatcttggaa    780

gcatttggaa atgctaaaac cctgagaaat gacaactcct ctcgttttgg caaattcatc    840

aggatgcact ttggtgccag aggcatgctg tcatctgtgg acattgatat ctatttgctt    900

gaaaagtcca gggtgatttt ccagcaggct ggagagagga actaccacat attctatcaa    960

attctatctg gacaaaaaga gcttcatgac ctgctcctgg tatctgcaaa tccctcagac   1020

ttccactttt gctcctgtgg agcagttact gtggagagct tggatgatgc tgaagaattg   1080

ctggccacag aacaagccat ggacatcttg ggctttcttc ctgatgagaa gtatggatgc   1140

tataaactca ctggagccat catgcacttt ggaaatatga aatttaaaca gaaacctaga   1200

gaagagcaac tggaagcaga tggcacagaa aatgctgaca aagctgcttt cctcatgggc   1260

attaactcct ctgagttggt aaagtgcttg atccatccta gaatcaaagt tggtaacgaa   1320

tatgttacca gaggtcaaac tatagaacag gtaacctgtg ctgtcggtgc cctgtccaag   1380

tcaatgtatg aaaggatgtt taagtggcta gtggcacgga tcaacagggc cctggatgcc   1440

aagctgtcaa ggcagttctt cattggcatt cttgacatca ctggttttga aatccttgag   1500

tataatagcc ttgagcaact ttgcattaat tttaccaatg aaaaattaca acaattcttc   1560

aattggcaca tgtttgttct ggagcaagag gaatataaga aagaaagcat tgaatgggtg   1620

tctattggct ttggtctgga tttgcaagct tgcatagatc tcattgagaa gccaatgggc   1680

atcctttcca tccttgaaga agagtgtatg tttcctaagg ctacagacct gactttcaag   1740

accaaactct ttgacaacca ttttggaaag tcggttcatc tccagaagcc caagcctgat   1800

aagaagaaat ttgaagctca ttttgaactt gtccattatg caggagtggt accttataat   1860

atcagtggtt ggctggaaaa gaacaaagac ctccttaatg aaacagtggt agctgtattt   1920

cagaagtctt ccaacagact cctggcgagc ctttttgaaa attacatgag tactgacagt   1980

gctataccat ttggggagaa gaaacgaaag aaaggagctt cattccaaac ggttgcatct   2040

ctgcataaag aaaacctgaa taaattgatg actaatctga aatcaacagc acctcatttt   2100

gtgagatgca taaatcccaa tgtgaacaaa ataccaggta tactggaccc ttacttggtt   2160

ctacagcagt tgcgctgtaa tggtgtcttg gaagggacta ggatatgccg tgaaggtttt   2220

ccaaaccgac tgcagtatgc tgattttaaa caaaggtact gcattctgaa tccaaggacc   2280

tttccaaaga gcaagtttgt gagcagcaga aaagcagctg aagaattact tggctccttg   2340

gagatagacc atacccagta ccgatttgga atcactaagg tgttttttaa agctgggttt   2400

ctgggccaac tggaagcaat aagagatgag agactatcta aagtcttcac attgttccaa   2460

gccagagcac agggcaaact gatgcgaatc aaattccaga agattctgga agaaagggat   2520

gcacttattt tgatccaatg gaacataaga gctttcatgg ctgtgaagaa ctggccctgg   2580

atgaggctct tcttcaagat caagcctctt gttaaatctt cagaagtagg agaagaagta   2640

gctggactga aggaagagtg tgcacaatta cagaaagcct tggagaaatc agagtttcag   2700

agggaggaac tgaaagcaaa gcaagtatcc ctcactcagg aaaaaaatga cctgattctt   2760

cagcttcagg ctgagcaaga gacactggca aatgttgaag agcagtgcga gtggctgatt   2820

aaatccaaga tccagctgga ggccagagta aaggagctgt cggagagggt ggaggaagaa   2880

gaggagataa attctgagct gactgccagg gggcggaaac tcgaagatga atgttttgag   2940

ttgaagaaag aaatcgatga cctggaaaca atgttggtga agtcagagaa ggagaagcgt   3000

actacagagc acaaggtcaa gaacttgact gaggaagtag agtttctaaa tgaggatatc   3060

agcaaactta acagagcagc caaggttgtg caggaggccc atcagcagac cctggatgac   3120

ctgcacatgg aggaggagaa gctcagcagc ctgagcaaag caaatctgaa gctggaacag   3180

caagttgatg agcttgaggg tgcccttgag caggagagaa aagcgagaat gaactgtgaa   3240

agggaactgc acaaactgga gggcaattta aagctgaatc gggaaagtat ggagaacctg   3300

gaaagcagcc agcgacacct ggcagaagag ctgaggaaaa aagaattaga attgagtcag   3360

atgaattcaa aagtggagaa tgagaaaggc ctggtagctc agcttcagaa gacggttaaa   3420

gagcttcaga ctcaaataaa ggatttgaaa gagaaactag aagctgaaag gaccactcga   3480

gccaagatgg aaagggagag agctgacctc acccaagacc tggctgactt gaatgagagg   3540

ctggaggagg taggaggatc cagtttggct cagctggaaa taactaagaa acaggaaacc   3600

aaattccaga agctgcaccg agacatggaa gaggccactc tgcactttga gacaacttct   3660

gcatctttga agaagagaca tgcagacagc ctggctgagc tcgagggcca ggtagaaaat   3720

ctacagcagg tcaagcagaa actggaaaaa gacaagagtg acttgcagct agaagtagat   3780

gacctcctga cccgtgttga gcagatgaca agagctaagg caaatgctga gaaactctgt   3840

actctatatg aagagcgctt gcatgaagca actgcaaagc tagataaggt gactcagttg   3900

gcaaatgacc tggcagcaca aaagacaaag ctgtggagtg agagtggcga gttcctacgg   3960

aggcttgaag agaaggaggc tctgataaac caactttcca gggaaaagag caacttcact   4020

cggcagattg aagacctgag agggcagctg gaaaaggaga ccaaatccca gagtgccctg   4080

gcccatgccc tgcagaaggc tcagcgtgac tgtgaccttc tacgagagca gtatgaggaa   4140

gaacaagagg tcaaggctga gctgcaccgg accttatcca aagtcaatgc tgaaatggtg   4200

caatggagaa tgaagtatga aaacaatgtc atccagagaa cagaagactt ggaggatgcc   4260

aagaaggaac tggcaattag attgcaggag gcagccgaag ccatgggggt ggccaatgcc   4320

agaaatgcct ccttggagag agccaggcac cagctgcagc tggagctcgg ggacgccctg   4380

tctgacctcg ggaaggtccg ctctgcagca gccaggctgg accagaagca gctgcagtct   4440

ggcaaggccc ttgccgactg gaagcagaag cacgaggagt cccaggcgtt gctggatgcc   4500

tctcagaagg aagttcaggc tctcagtaca gagctcctca agctcaagaa cacctatgag   4560

gagagcatcg tgggccagga gacactcagg agggagaaca agaacctcca agaagagatt   4620

tctaatctga caaaccaggt tagagaaggg accaagaact taactgaaat ggaaaaggtc   4680

aagaaactaa ttgaagaaga gaagacagaa gtccaggtga cactggaaga aacagaggga   4740

gccctggaac gtaatgaaag caagattctt catttccagc ttgaactctt ggaagctaaa   4800

gcagaacttg aaagaaagct ttcagagaaa gatgaagaaa tagaaaattt taggaggaag   4860

cagcagtgta ccattgactc cctgcagtct agtctggatt ctgaagctaa gagcagaatt   4920

gaggttaccc ggctgaagaa gaagatggaa gaggacctca atgagatgga actccagctt   4980

agctgtgcca accggcaggt gtcagaagca accaaatccc tgggccagct tcagattcaa   5040

atcaaggacc ttcaaatgca gctggatgac agcacacaac tgaacagtga tctgaaggag   5100

caggtggctg tggctgagcg gcgcaactct cttcttcagt ctgaactaga ggatctaagg   5160

tccctgcaag agcagacaga gcgtggccgc aggctgtcag aagaagagct cctggaagca   5220

acagaaagaa tcaatctttt ctatacccag aacacaagcc tcctcagcca gaagaagaaa   5280

ctggaggctg atgttgcccg gatgcagaaa gaagctgaag aggtggtgca ggagtgtcaa   5340

aatgcagaag agaaggccaa gaaggcagcc attgaggcag caaacttgtc agaagaactg   5400

aagaagaagc aagacaccat tgcccacttg gaaaggacaa gagaaaatat ggagcagaca   5460

attacagact tacagaaaag gctggctgaa gctgaacaga tggccctgat ggggagtaga   5520

aagcaaatcc agaaactaga atccagggtt cgtgaactgg aaggtgaact ggagggtgaa   5580

atccgtcgca gtgcagaggc ccagagggga gcccgcagac ttgagcgatg catcaaagag   5640

ctgacctatc aggcagagga agacaagaag aatctgagca ggatgcaaac tcagatggat   5700

aaacttcagc taaaagtgca aaattacaag cagcaagtcg aggtggcgga aacacaagcc   5760

aatcaatacc tttccaagta taagaaacag caacatgagt tgaatgaagt gaaggaaagg   5820

gcagaggtgg cagaatctca agtcaataaa ctcaaaatta aagcaagaga gtttgggaaa   5880

aaggttcaag aagaatagca tcccctgctt tgaaaggaca acagctggag aagtacaagg   5940

aaggtgctgt ttcatggcca aaaacttagg ttgcatggaa acatttttaa aaacatgttt   6000

aaattgcttt tcacaccata taaacaaggc aattagaaaa ataattaaag ggaatatcat   6060

tgcttccaca gttaatgggg attttttgat cctcaaatgc aagtaaacta ccttctaatg   6120

cttcacatga cagattaaat aaatggaaga accttttcaa ttctgatgtt taaaaaatga   6180

ataaatactt gatcctttgt ccatatttcc tcttaatggg taggactcat agaagatgtc   6240

cttagaccag tcacgcttca tggggactag ggcatgttgg tgaatggttt ttactaaagt   6300

taggcaactt tggcttgatt cacccctaaa tctatgaatg tatattgtga gccagcagtg   6360

gtagaatgga agtcataaga tctcctcagc attgtgatat aaatatagct atagttaggc   6420

aatttgaaca tgtaggcaaa actctcctaa tcaacacaca tgtaggctat atgctggtac   6480

atgctttaaa catggaggta accccacacg agacattcag tgacaggtaa tatgctggat   6540

ttgtgcagta ccgatttggc tcagctggag gaacatgtcc cggaattcct ctctctcatg   6600

gttctggatt ggagtaggtc ataaagaaat ttgcattaat ttgatcagca gctattttat   6660

actcataagg tcagtgtaca gacccaagca tggtgacagc ttgaaaatat gactccaggc   6720

caaaaagggg agctagaaga gaccagagac agctccctgg acccagagct cttccagctc   6780

ctgccagcct cctccttcag ctttgcaaag tactggccag gtgtgtgtgc agctccatgg   6840

caaccagcat cagcttttcc tgagatcaca cacagcattg cagtggaggc cgtgagacag   6900

acatgggttc tgtttgttct tatggacttc ccttcatcct tgctgcattc acagtcgacc   6960

tacagtgact tcaggcccag aaccagatgc agagggaaca gcctggccta gacttctcca   7020

ccagcaccca caattgtgta aggctgaagc tctataataa atctttattc tgtc         7074


<210>  1695
<211>  1946
<212>  PRT
<213>  Homo sapiens

<400>  1695


Met Val Glu Ser Cys Leu Leu Thr Phe Arg Ala Phe Phe Trp Trp Ile 
1               5                   10                  15      


Ala Leu Ile Lys Met Asp Leu Ser Asp Leu Gly Glu Ala Ala Ala Phe 
            20                  25                  30          


Leu Arg Arg Ser Glu Ala Glu Leu Leu Leu Leu Gln Ala Thr Ala Leu 
        35                  40                  45              


Asp Gly Lys Lys Lys Cys Trp Ile Pro Asp Gly Glu Asn Ala Tyr Ile 
    50                  55                  60                  


Glu Ala Glu Val Lys Gly Ser Glu Asp Asp Gly Thr Val Ile Val Glu 
65                  70                  75                  80  


Thr Ala Asp Gly Glu Ser Leu Ser Ile Lys Glu Asp Lys Ile Gln Gln 
                85                  90                  95      


Met Asn Pro Pro Glu Phe Glu Met Ile Glu Asp Met Ala Met Leu Thr 
            100                 105                 110         


His Leu Asn Glu Ala Ser Val Leu His Thr Leu Lys Arg Arg Tyr Gly 
        115                 120                 125             


Gln Trp Met Ile Tyr Thr Tyr Ser Gly Leu Phe Cys Val Thr Ile Asn 
    130                 135                 140                 


Pro Tyr Lys Trp Leu Pro Val Tyr Gln Lys Glu Val Met Ala Ala Tyr 
145                 150                 155                 160 


Lys Gly Lys Arg Arg Ser Glu Ala Pro Pro His Ile Phe Ala Val Ala 
                165                 170                 175     


Asn Asn Ala Phe Gln Asp Met Leu His Asn Arg Glu Asn Gln Ser Ile 
            180                 185                 190         


Leu Phe Thr Gly Glu Ser Gly Ala Gly Lys Thr Val Asn Ser Lys His 
        195                 200                 205             


Ile Ile Gln Tyr Phe Ala Thr Ile Ala Ala Met Ile Glu Ser Arg Lys 
    210                 215                 220                 


Lys Gln Gly Ala Leu Glu Asp Gln Ile Met Gln Ala Asn Thr Ile Leu 
225                 230                 235                 240 


Glu Ala Phe Gly Asn Ala Lys Thr Leu Arg Asn Asp Asn Ser Ser Arg 
                245                 250                 255     


Phe Gly Lys Phe Ile Arg Met His Phe Gly Ala Arg Gly Met Leu Ser 
            260                 265                 270         


Ser Val Asp Ile Asp Ile Tyr Leu Leu Glu Lys Ser Arg Val Ile Phe 
        275                 280                 285             


Gln Gln Ala Gly Glu Arg Asn Tyr His Ile Phe Tyr Gln Ile Leu Ser 
    290                 295                 300                 


Gly Gln Lys Glu Leu His Asp Leu Leu Leu Val Ser Ala Asn Pro Ser 
305                 310                 315                 320 


Asp Phe His Phe Cys Ser Cys Gly Ala Val Thr Val Glu Ser Leu Asp 
                325                 330                 335     


Asp Ala Glu Glu Leu Leu Ala Thr Glu Gln Ala Met Asp Ile Leu Gly 
            340                 345                 350         


Phe Leu Pro Asp Glu Lys Tyr Gly Cys Tyr Lys Leu Thr Gly Ala Ile 
        355                 360                 365             


Met His Phe Gly Asn Met Lys Phe Lys Gln Lys Pro Arg Glu Glu Gln 
    370                 375                 380                 


Leu Glu Ala Asp Gly Thr Glu Asn Ala Asp Lys Ala Ala Phe Leu Met 
385                 390                 395                 400 


Gly Ile Asn Ser Ser Glu Leu Val Lys Cys Leu Ile His Pro Arg Ile 
                405                 410                 415     


Lys Val Gly Asn Glu Tyr Val Thr Arg Gly Gln Thr Ile Glu Gln Val 
            420                 425                 430         


Thr Cys Ala Val Gly Ala Leu Ser Lys Ser Met Tyr Glu Arg Met Phe 
        435                 440                 445             


Lys Trp Leu Val Ala Arg Ile Asn Arg Ala Leu Asp Ala Lys Leu Ser 
    450                 455                 460                 


Arg Gln Phe Phe Ile Gly Ile Leu Asp Ile Thr Gly Phe Glu Ile Leu 
465                 470                 475                 480 


Glu Tyr Asn Ser Leu Glu Gln Leu Cys Ile Asn Phe Thr Asn Glu Lys 
                485                 490                 495     


Leu Gln Gln Phe Phe Asn Trp His Met Phe Val Leu Glu Gln Glu Glu 
            500                 505                 510         


Tyr Lys Lys Glu Ser Ile Glu Trp Val Ser Ile Gly Phe Gly Leu Asp 
        515                 520                 525             


Leu Gln Ala Cys Ile Asp Leu Ile Glu Lys Pro Met Gly Ile Leu Ser 
    530                 535                 540                 


Ile Leu Glu Glu Glu Cys Met Phe Pro Lys Ala Thr Asp Leu Thr Phe 
545                 550                 555                 560 


Lys Thr Lys Leu Phe Asp Asn His Phe Gly Lys Ser Val His Leu Gln 
                565                 570                 575     


Lys Pro Lys Pro Asp Lys Lys Lys Phe Glu Ala His Phe Glu Leu Val 
            580                 585                 590         


His Tyr Ala Gly Val Val Pro Tyr Asn Ile Ser Gly Trp Leu Glu Lys 
        595                 600                 605             


Asn Lys Asp Leu Leu Asn Glu Thr Val Val Ala Val Phe Gln Lys Ser 
    610                 615                 620                 


Ser Asn Arg Leu Leu Ala Ser Leu Phe Glu Asn Tyr Met Ser Thr Asp 
625                 630                 635                 640 


Ser Ala Ile Pro Phe Gly Glu Lys Lys Arg Lys Lys Gly Ala Ser Phe 
                645                 650                 655     


Gln Thr Val Ala Ser Leu His Lys Glu Asn Leu Asn Lys Leu Met Thr 
            660                 665                 670         


Asn Leu Lys Ser Thr Ala Pro His Phe Val Arg Cys Ile Asn Pro Asn 
        675                 680                 685             


Val Asn Lys Ile Pro Gly Ile Leu Asp Pro Tyr Leu Val Leu Gln Gln 
    690                 695                 700                 


Leu Arg Cys Asn Gly Val Leu Glu Gly Thr Arg Ile Cys Arg Glu Gly 
705                 710                 715                 720 


Phe Pro Asn Arg Leu Gln Tyr Ala Asp Phe Lys Gln Arg Tyr Cys Ile 
                725                 730                 735     


Leu Asn Pro Arg Thr Phe Pro Lys Ser Lys Phe Val Ser Ser Arg Lys 
            740                 745                 750         


Ala Ala Glu Glu Leu Leu Gly Ser Leu Glu Ile Asp His Thr Gln Tyr 
        755                 760                 765             


Arg Phe Gly Ile Thr Lys Val Phe Phe Lys Ala Gly Phe Leu Gly Gln 
    770                 775                 780                 


Leu Glu Ala Ile Arg Asp Glu Arg Leu Ser Lys Val Phe Thr Leu Phe 
785                 790                 795                 800 


Gln Ala Arg Ala Gln Gly Lys Leu Met Arg Ile Lys Phe Gln Lys Ile 
                805                 810                 815     


Leu Glu Glu Arg Asp Ala Leu Ile Leu Ile Gln Trp Asn Ile Arg Ala 
            820                 825                 830         


Phe Met Ala Val Lys Asn Trp Pro Trp Met Arg Leu Phe Phe Lys Ile 
        835                 840                 845             


Lys Pro Leu Val Lys Ser Ser Glu Val Gly Glu Glu Val Ala Gly Leu 
    850                 855                 860                 


Lys Glu Glu Cys Ala Gln Leu Gln Lys Ala Leu Glu Lys Ser Glu Phe 
865                 870                 875                 880 


Gln Arg Glu Glu Leu Lys Ala Lys Gln Val Ser Leu Thr Gln Glu Lys 
                885                 890                 895     


Asn Asp Leu Ile Leu Gln Leu Gln Ala Glu Gln Glu Thr Leu Ala Asn 
            900                 905                 910         


Val Glu Glu Gln Cys Glu Trp Leu Ile Lys Ser Lys Ile Gln Leu Glu 
        915                 920                 925             


Ala Arg Val Lys Glu Leu Ser Glu Arg Val Glu Glu Glu Glu Glu Ile 
    930                 935                 940                 


Asn Ser Glu Leu Thr Ala Arg Gly Arg Lys Leu Glu Asp Glu Cys Phe 
945                 950                 955                 960 


Glu Leu Lys Lys Glu Ile Asp Asp Leu Glu Thr Met Leu Val Lys Ser 
                965                 970                 975     


Glu Lys Glu Lys Arg Thr Thr Glu His Lys Val Lys Asn Leu Thr Glu 
            980                 985                 990         


Glu Val Glu Phe Leu Asn Glu Asp  Ile Ser Lys Leu Asn  Arg Ala Ala 
        995                 1000                 1005             


Lys Val  Val Gln Glu Ala His  Gln Gln Thr Leu Asp  Asp Leu His 
    1010                 1015                 1020             


Met Glu  Glu Glu Lys Leu Ser  Ser Leu Ser Lys Ala  Asn Leu Lys 
    1025                 1030                 1035             


Leu Glu  Gln Gln Val Asp Glu  Leu Glu Gly Ala Leu  Glu Gln Glu 
    1040                 1045                 1050             


Arg Lys  Ala Arg Met Asn Cys  Glu Arg Glu Leu His  Lys Leu Glu 
    1055                 1060                 1065             


Gly Asn  Leu Lys Leu Asn Arg  Glu Ser Met Glu Asn  Leu Glu Ser 
    1070                 1075                 1080             


Ser Gln  Arg His Leu Ala Glu  Glu Leu Arg Lys Lys  Glu Leu Glu 
    1085                 1090                 1095             


Leu Ser  Gln Met Asn Ser Lys  Val Glu Asn Glu Lys  Gly Leu Val 
    1100                 1105                 1110             


Ala Gln  Leu Gln Lys Thr Val  Lys Glu Leu Gln Thr  Gln Ile Lys 
    1115                 1120                 1125             


Asp Leu  Lys Glu Lys Leu Glu  Ala Glu Arg Thr Thr  Arg Ala Lys 
    1130                 1135                 1140             


Met Glu  Arg Glu Arg Ala Asp  Leu Thr Gln Asp Leu  Ala Asp Leu 
    1145                 1150                 1155             


Asn Glu  Arg Leu Glu Glu Val  Gly Gly Ser Ser Leu  Ala Gln Leu 
    1160                 1165                 1170             


Glu Ile  Thr Lys Lys Gln Glu  Thr Lys Phe Gln Lys  Leu His Arg 
    1175                 1180                 1185             


Asp Met  Glu Glu Ala Thr Leu  His Phe Glu Thr Thr  Ser Ala Ser 
    1190                 1195                 1200             


Leu Lys  Lys Arg His Ala Asp  Ser Leu Ala Glu Leu  Glu Gly Gln 
    1205                 1210                 1215             


Val Glu  Asn Leu Gln Gln Val  Lys Gln Lys Leu Glu  Lys Asp Lys 
    1220                 1225                 1230             


Ser Asp  Leu Gln Leu Glu Val  Asp Asp Leu Leu Thr  Arg Val Glu 
    1235                 1240                 1245             


Gln Met  Thr Arg Ala Lys Ala  Asn Ala Glu Lys Leu  Cys Thr Leu 
    1250                 1255                 1260             


Tyr Glu  Glu Arg Leu His Glu  Ala Thr Ala Lys Leu  Asp Lys Val 
    1265                 1270                 1275             


Thr Gln  Leu Ala Asn Asp Leu  Ala Ala Gln Lys Thr  Lys Leu Trp 
    1280                 1285                 1290             


Ser Glu  Ser Gly Glu Phe Leu  Arg Arg Leu Glu Glu  Lys Glu Ala 
    1295                 1300                 1305             


Leu Ile  Asn Gln Leu Ser Arg  Glu Lys Ser Asn Phe  Thr Arg Gln 
    1310                 1315                 1320             


Ile Glu  Asp Leu Arg Gly Gln  Leu Glu Lys Glu Thr  Lys Ser Gln 
    1325                 1330                 1335             


Ser Ala  Leu Ala His Ala Leu  Gln Lys Ala Gln Arg  Asp Cys Asp 
    1340                 1345                 1350             


Leu Leu  Arg Glu Gln Tyr Glu  Glu Glu Gln Glu Val  Lys Ala Glu 
    1355                 1360                 1365             


Leu His  Arg Thr Leu Ser Lys  Val Asn Ala Glu Met  Val Gln Trp 
    1370                 1375                 1380             


Arg Met  Lys Tyr Glu Asn Asn  Val Ile Gln Arg Thr  Glu Asp Leu 
    1385                 1390                 1395             


Glu Asp  Ala Lys Lys Glu Leu  Ala Ile Arg Leu Gln  Glu Ala Ala 
    1400                 1405                 1410             


Glu Ala  Met Gly Val Ala Asn  Ala Arg Asn Ala Ser  Leu Glu Arg 
    1415                 1420                 1425             


Ala Arg  His Gln Leu Gln Leu  Glu Leu Gly Asp Ala  Leu Ser Asp 
    1430                 1435                 1440             


Leu Gly  Lys Val Arg Ser Ala  Ala Ala Arg Leu Asp  Gln Lys Gln 
    1445                 1450                 1455             


Leu Gln  Ser Gly Lys Ala Leu  Ala Asp Trp Lys Gln  Lys His Glu 
    1460                 1465                 1470             


Glu Ser  Gln Ala Leu Leu Asp  Ala Ser Gln Lys Glu  Val Gln Ala 
    1475                 1480                 1485             


Leu Ser  Thr Glu Leu Leu Lys  Leu Lys Asn Thr Tyr  Glu Glu Ser 
    1490                 1495                 1500             


Ile Val  Gly Gln Glu Thr Leu  Arg Arg Glu Asn Lys  Asn Leu Gln 
    1505                 1510                 1515             


Glu Glu  Ile Ser Asn Leu Thr  Asn Gln Val Arg Glu  Gly Thr Lys 
    1520                 1525                 1530             


Asn Leu  Thr Glu Met Glu Lys  Val Lys Lys Leu Ile  Glu Glu Glu 
    1535                 1540                 1545             


Lys Thr  Glu Val Gln Val Thr  Leu Glu Glu Thr Glu  Gly Ala Leu 
    1550                 1555                 1560             


Glu Arg  Asn Glu Ser Lys Ile  Leu His Phe Gln Leu  Glu Leu Leu 
    1565                 1570                 1575             


Glu Ala  Lys Ala Glu Leu Glu  Arg Lys Leu Ser Glu  Lys Asp Glu 
    1580                 1585                 1590             


Glu Ile  Glu Asn Phe Arg Arg  Lys Gln Gln Cys Thr  Ile Asp Ser 
    1595                 1600                 1605             


Leu Gln  Ser Ser Leu Asp Ser  Glu Ala Lys Ser Arg  Ile Glu Val 
    1610                 1615                 1620             


Thr Arg  Leu Lys Lys Lys Met  Glu Glu Asp Leu Asn  Glu Met Glu 
    1625                 1630                 1635             


Leu Gln  Leu Ser Cys Ala Asn  Arg Gln Val Ser Glu  Ala Thr Lys 
    1640                 1645                 1650             


Ser Leu  Gly Gln Leu Gln Ile  Gln Ile Lys Asp Leu  Gln Met Gln 
    1655                 1660                 1665             


Leu Asp  Asp Ser Thr Gln Leu  Asn Ser Asp Leu Lys  Glu Gln Val 
    1670                 1675                 1680             


Ala Val  Ala Glu Arg Arg Asn  Ser Leu Leu Gln Ser  Glu Leu Glu 
    1685                 1690                 1695             


Asp Leu  Arg Ser Leu Gln Glu  Gln Thr Glu Arg Gly  Arg Arg Leu 
    1700                 1705                 1710             


Ser Glu  Glu Glu Leu Leu Glu  Ala Thr Glu Arg Ile  Asn Leu Phe 
    1715                 1720                 1725             


Tyr Thr  Gln Asn Thr Ser Leu  Leu Ser Gln Lys Lys  Lys Leu Glu 
    1730                 1735                 1740             


Ala Asp  Val Ala Arg Met Gln  Lys Glu Ala Glu Glu  Val Val Gln 
    1745                 1750                 1755             


Glu Cys  Gln Asn Ala Glu Glu  Lys Ala Lys Lys Ala  Ala Ile Glu 
    1760                 1765                 1770             


Ala Ala  Asn Leu Ser Glu Glu  Leu Lys Lys Lys Gln  Asp Thr Ile 
    1775                 1780                 1785             


Ala His  Leu Glu Arg Thr Arg  Glu Asn Met Glu Gln  Thr Ile Thr 
    1790                 1795                 1800             


Asp Leu  Gln Lys Arg Leu Ala  Glu Ala Glu Gln Met  Ala Leu Met 
    1805                 1810                 1815             


Gly Ser  Arg Lys Gln Ile Gln  Lys Leu Glu Ser Arg  Val Arg Glu 
    1820                 1825                 1830             


Leu Glu  Gly Glu Leu Glu Gly  Glu Ile Arg Arg Ser  Ala Glu Ala 
    1835                 1840                 1845             


Gln Arg  Gly Ala Arg Arg Leu  Glu Arg Cys Ile Lys  Glu Leu Thr 
    1850                 1855                 1860             


Tyr Gln  Ala Glu Glu Asp Lys  Lys Asn Leu Ser Arg  Met Gln Thr 
    1865                 1870                 1875             


Gln Met  Asp Lys Leu Gln Leu  Lys Val Gln Asn Tyr  Lys Gln Gln 
    1880                 1885                 1890             


Val Glu  Val Ala Glu Thr Gln  Ala Asn Gln Tyr Leu  Ser Lys Tyr 
    1895                 1900                 1905             


Lys Lys  Gln Gln His Glu Leu  Asn Glu Val Lys Glu  Arg Ala Glu 
    1910                 1915                 1920             


Val Ala  Glu Ser Gln Val Asn  Lys Leu Lys Ile Lys  Ala Arg Glu 
    1925                 1930                 1935             


Phe Gly  Lys Lys Val Gln Glu  Glu 
    1940                 1945     

<210>  1696
<211>  839
<212>  DNA
<213>  Homo sapiens

<400>  1696
gctcccctcc cttcacgttg cacctctctg aggaggtaca ggagggaaga atggctccag     60

tggggagtaa gaggtggggt cagatgtgct aggcacattc ttgcctcagg gcactggcct    120

tcccgttctc aagaaggccc cttggagaag gtggcattgg cgtcaaggag aaggcaggaa    180

aagaggatat ctgggttcgt gaactggaag gtgaactgga gggtgaaatc cgtcgcagtg    240

cagaggccca gaggggagcc cgcagacttg agcgatgcat caaagagctg acctatcagg    300

cagaggaaga caagaagaat ctgagcagga tgcaaactca gatggataaa cttcagctaa    360

aagtgcaaaa ttacaagcag caagtcgagg tggcggaaac acaagccaat caataccttt    420

ccaagtataa gaaacagcaa catgagttga atgaagtgaa ggaaagggca gaggtggcag    480

aatctcaagt caataaactc aaaattaaag caagagagtt tgggaaaaag gttcaagaag    540

aatagcatcc cctgctttga aaggacaaca gctggagaag tacaaggaag gtgctgtttc    600

atggccaaaa acttaggttg catggaaaca tttttaaaaa catgtttaaa ttgcttttca    660

caccatataa acaaggcaat tagaaaaata attaaaggga atatcattgc ttccacagtt    720

aatggggatt ttttgatcct caaatgcaag taaactacct tctaatgctt cacatgacag    780

attaaataaa tggaagaacc ttttcaattc tgatgtttaa aaaatgaata aatacttga     839


<210>  1697
<211>  71
<212>  PRT
<213>  Homo sapiens

<400>  1697


Met Gln Thr Gln Met Asp Lys Leu Gln Leu Lys Val Gln Asn Tyr Lys 
1               5                   10                  15      


Gln Gln Val Glu Val Ala Glu Thr Gln Ala Asn Gln Tyr Leu Ser Lys 
            20                  25                  30          


Tyr Lys Lys Gln Gln His Glu Leu Asn Glu Val Lys Glu Arg Ala Glu 
        35                  40                  45              


Val Ala Glu Ser Gln Val Asn Lys Leu Lys Ile Lys Ala Arg Glu Phe 
    50                  55                  60                  


Gly Lys Lys Val Gln Glu Glu 
65                  70      

<210>  1698
<211>  1447
<212>  DNA
<213>  Homo sapiens

<400>  1698
acatatttac atacatacac atatggtgag ggagagaacg tgatgacgtg agactctcca     60

tggagagtag gaggtaataa agaaataaaa caggtgtctg aggagaggtt ctattagaga    120

ggggagaata gagagtaatt atcgttcaga caggcaagag ttctctgcag gtagcagcct    180

gggaaagcga actcgcgcac cctcttgggg gacgggctct tttgctttct atttcttctc    240

ctgcagccag ggtgcacacg tatttgaaac agaccgaatt tcctcctcga tgtggcgtca    300

ggttgacttt tcgagactag cgggtatttc tttttaatga ctccaatgcc tttttattat    360

tgctgttatt gaggttgagg gagaagagat cggtctaaat tctggctggg taagtggggg    420

gattctcggc gatgagaaac gggggactta gaagccggag gaaaatcagc agccccacat    480

ctccacttct ccagtccgcc ctactctcca cccgtgacct ccagtggaga ccccaggcgg    540

cagcatcagt atttgatcgg cccttcgtca gcacgctgcc agccctggcc ggctgggttc    600

gccaggcatc acccgctcgg ctctgaagcg gacgcctggc cctgcaccgg gctttggaag    660

gaccctctct gcgctcgccc cctccccagg gtggctccgc tttcgagccc gggcgcggtg    720

cccaccatgc gcggctgcct gcggctcgcg ctgctctgcg cgctgccctg gctcctgctg    780

gcggcgtcgc ccgggcaccc ggcgaaatcc cccaggcagc ccccggcacc gcgccgcgac    840

cccttcgacg ctgccagggg cgccgatttc gatcatgtct acagcggggt ggtgaacctc    900

agcaccgaga acatctactc tttcaactac accagccagc ccgaccaggt gacagccgtg    960

agggtgtatg tgaacagttc ctctgagaat ctcaactacc cggtccttgt tgtggttcgc   1020

cagcagaaag aggtgctgtc ctggcaggtt cctctgctct tccaaggact ataccagagg   1080

agctacaact atcaagaagt gagccgcacc ttatgtccct cagaagcaac caatgagacg   1140

ggacccttgc agcaactgat atttgtagat gtcgcatcca tggcacccct gggtgctcag   1200

tacaaactgc tagttaccaa gctgaagcac ttccagctcc ggtaagcggg actttctctg   1260

tttacctgtc tgtgtttcct gtgcttgtgg atgctcaatt catcttccat ccttacagac   1320

tggtactctg gaaggaaatt atccacttag catatgattt tagcacttcc tgaactctcc   1380

tgcccataac tgagcagcag ggccttaatc tatacaaaag agtgggagtg cagaaggtaa   1440

gagtggt                                                             1447


<210>  1699
<211>  172
<212>  PRT
<213>  Homo sapiens

<400>  1699


Met Arg Gly Cys Leu Arg Leu Ala Leu Leu Cys Ala Leu Pro Trp Leu 
1               5                   10                  15      


Leu Leu Ala Ala Ser Pro Gly His Pro Ala Lys Ser Pro Arg Gln Pro 
            20                  25                  30          


Pro Ala Pro Arg Arg Asp Pro Phe Asp Ala Ala Arg Gly Ala Asp Phe 
        35                  40                  45              


Asp His Val Tyr Ser Gly Val Val Asn Leu Ser Thr Glu Asn Ile Tyr 
    50                  55                  60                  


Ser Phe Asn Tyr Thr Ser Gln Pro Asp Gln Val Thr Ala Val Arg Val 
65                  70                  75                  80  


Tyr Val Asn Ser Ser Ser Glu Asn Leu Asn Tyr Pro Val Leu Val Val 
                85                  90                  95      


Val Arg Gln Gln Lys Glu Val Leu Ser Trp Gln Val Pro Leu Leu Phe 
            100                 105                 110         


Gln Gly Leu Tyr Gln Arg Ser Tyr Asn Tyr Gln Glu Val Ser Arg Thr 
        115                 120                 125             


Leu Cys Pro Ser Glu Ala Thr Asn Glu Thr Gly Pro Leu Gln Gln Leu 
    130                 135                 140                 


Ile Phe Val Asp Val Ala Ser Met Ala Pro Leu Gly Ala Gln Tyr Lys 
145                 150                 155                 160 


Leu Leu Val Thr Lys Leu Lys His Phe Gln Leu Arg 
                165                 170         

<210>  1700
<211>  5079
<212>  DNA
<213>  Homo sapiens

<400>  1700
acatatttac atacatacac atatggtgag ggagagaacg tgatgacgtg agactctcca     60

tggagagtag gaggtaataa agaaataaaa caggtgtctg aggagaggtt ctattagaga    120

ggggagaata gagagtaatt atcgttcaga caggcaagag ttctctgcag gtagcagcct    180

gggaaagcga actcgcgcac cctcttgggg gacgggctct tttgctttct atttcttctc    240

ctgcagccag ggtgcacacg tatttgaaac agaccgaatt tcctcctcga tgtggcgtca    300

ggttgacttt tcgagactag cgggtatttc tttttaatga ctccaatgcc tttttattat    360

tgctgttatt gaggttgagg gagaagagat cggtctaaat tctggctggg taagtggggg    420

gattctcggc gatgagaaac gggggactta gaagccggag gaaaatcagc agccccacat    480

ctccacttct ccagtccgcc ctactctcca cccgtgacct ccagtggaga ccccaggcgg    540

cagcatcagt atttgatcgg cccttcgtca gcacgctgcc agccctggcc ggctgggttc    600

gccaggcatc acccgctcgg ctctgaagcg gacgcctggc cctgcaccgg gctttggaag    660

gaccctctct gcgctcgccc cctccccagg gtggctccgc tttcgagccc gggcgcggtg    720

cccaccatgc gcggctgcct gcggctcgcg ctgctctgcg cgctgccctg gctcctgctg    780

gcggcgtcgc ccgggcaccc ggcgaaatcc cccaggcagc ccccggcacc gcgccgcgac    840

cccttcgacg ctgccagggg cgccgatttc gatcatgtct acagcggggt ggtgaacctc    900

agcaccgaga acatctactc tttcaactac accagccagc ccgaccaggt gacagccgtg    960

agggtgtatg tgaacagttc ctctgagaat ctcaactacc cggtccttgt tgtggttcgc   1020

cagcagaaag aggtgctgtc ctggcaggtt cctctgctct tccaaggact ataccagagg   1080

agctacaact atcaagaagt gagccgcacc ttatgtccct cagaagcaac caatgagacg   1140

ggacccttgc agcaactgat atttgtagat gtcgcatcca tggcacccct gggtgctcag   1200

tacaaactgc tagttaccaa gctgaagcac ttccagctcc ggacaaatgt tgcctttcac   1260

tttactgcca gcccctctca acctcagtat tttctataca agtttcccaa agacgtggac   1320

tcagttatca ttaaagtggt gtctgaaatg gcttatccat gttctgttgt ctcagtccag   1380

aatatcatgt gcccggtgta tgatctcgac cacaatgtgg aatttaatgg tgtctatcag   1440

tccatgacca agaaagctgc catcacgcta cagaagaagg attttccagg cgagcagttc   1500

ttcgtggtat ttgtgataaa gcctgaagat tatgcctgtg gaggatcttt cttcatccag   1560

gaaaaggaaa accagacctg gaatctacag cgaaaaaaga accttgaagt gaccattgtc   1620

ccttccatta aagaatctgt ttatgtgaaa tccagtcttt tcagtgtctt catcttcctg   1680

tccttctact tgggatgcct tcttgttggg tttgttcatt atctgaggtt tcagagaaaa   1740

tccattgatg gaagctttgg gtccaatgat ggctctggaa atatggtggc atctcatccc   1800

attgctgcca gcacacccga agggagcaat tatgggacaa tagatgagtc aagctccagt   1860

cctggaaggc agatgtcctc ctccgatggt gggccaccgg gccagtcaga cacagacagc   1920

tccgtggagg agagcgactt cgacaccatg ccagacattg agagtgataa aaacatcatc   1980

cggaccaaga tgttccttta cctgtcagat ttgtccagga aggaccggag aattgtcagc   2040

aaaaaatata aaatttattt ttggaacatc atcaccattg ctgtgtttta cgcgctgccc   2100

gtgatccagc tggtcattac ctatcagaca gtggtaaatg tcactggcaa ccaggacatc   2160

tgttactaca acttcctctg tgctcacccc ttgggcgtcc tgagtgcctt caacaacatt   2220

ctcagcaatc tgggccacgt gcttctgggc ttcctcttcc tgctgatagt cttgcgccgc   2280

gacatcctcc atcggagagc cctggaagcc aaggacatct ttgctgtgga gtacgggatt   2340

cccaaacact ttggtctctt ctacgctatg ggcattgcat tgatgatgga aggggtgctc   2400

agtgcttgct accatgtctg ccctaattat tccaacttcc aattcgacac ctccttcatg   2460

tacatgatcg ctggcctgtg catgctgaag ctctatcaga cccgccaccc agacatcaat   2520

gccagcgcct actctgccta tgcctccttt gctgtggtca tcatggtcac cgtccttgga   2580

gtggtgtttg gaaaaaatga cgtatggttc tgggtcatct tctctgcaat ccacgttctg   2640

gcctcgctag ccctcagcac ccagatatat tatatgggtc gtttcaagat agatttggga   2700

attttccggc gggctgccat ggtgttctac acagactgta tccagcagtg tagccgacct   2760

ctatatatgg atagaatggt gttgctggtt gtggggaatc tggttaactg gtccttcgcc   2820

ctctttggat tgatataccg ccccagggac tttgcttcct acatgctggg catcttcatc   2880

tgtaaccttt tgctgtacct ggccttttac atcatcatga agctccgcag ctctgaaaag   2940

gtcctcccag tcccgctctt ctgcatcgtg gccaccgctg tgatgtgggc tgccgcccta   3000

tattttttct tccagaatct cagcagctgg gagggaactc cggccgaatc ccgggagaag   3060

aaccgcgagt gcattctgct ggatttcttc gatgaccatg acatctggca cttcctctct   3120

gctactgctc tgtttttctc attcttggtt ttgttaactt tggatgatga ccttgatgtg   3180

gttcggagag accagatccc tgtcttctga acctccaaca ttaagagagg ggagggagcg   3240

atcaatcttg gtgctgtttc acaaaaatta cagtgaccac agcaaagtaa ccactgccag   3300

atgctccact caccctctgt agagccaact ctgcattcac acaggaagga gaggggctgc   3360

gggagattta aacctgcaag aaaggaggca gaaggggagc catgttttga ggacagacgc   3420

aaacctgagg agctgagaaa cacttgctcc ttccatctgc agctttggga gtgcaacagg   3480

gataggcact gcatccaagt caactcacca tcttggggtc cctcccaccc tcacggagac   3540

ttgccagcaa tggcagaatg ctgctgcaca cttccctcca gttgtcaccc tgcccagaaa   3600

ggccagcagc ttggacttcc tgcccagaaa ctgtgttggc ccccttcaca cctctgcaac   3660

acctgctgct ccagcaagag gatgtgattc tttagaatat ggcggggagg tgaccccagg   3720

ccctgcccta ctgggataga tgttttaatg gcaccagcta gtcacctccc agaagaaact   3780

ctgtatattt cccccaggtt tctgatgcca tcagaagggc tcaggagtgg ggtttgtcac   3840

acattcctct taacaagtaa ctgtcactgg gaccgagtcc tgggtgctta catattcctt   3900

cgtgtcttca tctcactgac ctgtgtggac ctcatcactc tgactctgcc ttcttggaaa   3960

ggccctgtca ctccacagat gtctggccag cttcaaggca gaaggaaaaa caggaaaagc   4020

tcttttaaca gcagcaggaa caagagaaat gactaaccat actaaaagac tggtaacagc   4080

agcagcagcc agacaggcct caccttaagg acttgggctg ccagagcaaa ttcagcagag   4140

cttatttggc ctcccattca cacagctcag ttctgtgccc acatcacctt tggggaagaa   4200

atcagcattc taatcaggga cactacttca ggagtcctcc acagcgagtc cgtcatctgt   4260

cactttatgt agatcagggt tctagacttc ttccctgagg ttctcagaag cagctctcag   4320

gatgaacgta ttgtcctctt cccctcttct tgcaaagtgc acagctaatc taatgttgtc   4380

tctcggttgc acctgacatt ctctccccag taaggtgttg gcaagctcag catctgggtt   4440

ccactctcac actgtctggc agctctgtgt ctgagaagtt ctacattgac caggccccct   4500

tgttgcctgg agtatgacgt aatcagaaaa tagacgtata aatgtgcaca tgcgtatgta   4560

tttgcttgtg aaattaaagt cacctcttgc ctctgctttc ctgatcattc gttagagaaa   4620

tggatcaggc atttttttaa attattattc tttctctaaa ctatttgcat tgtgttcaaa   4680

aacccatttt agaagtttga acagcaagct tttcctgatt ttaaaaacac aaagttgctt   4740

tcaatgaaat attttgtgat ttttttaaag tccccaaatg tgtacttagc cttctgttat   4800

tccttattct ttaagcagtg ttggcttcca ttgaccatat gaaggccacc aattaaatgg   4860

ttgtgttaat ccaacatgta aaaaactttt tggcagggca cagtggctca cgcctgtaat   4920

cccaacactt tgggaggctg aggcaggagg atcacttgag cccaggagat tgacgccgca   4980

gtgaactatg attgtgcccc tgcactccag cctggatgac agagtgagac cccatctctt   5040

aaaaaataaa aaaaaataaa aatttgaacc tgtttcact                          5079


<210>  1701
<211>  827
<212>  PRT
<213>  Homo sapiens

<400>  1701


Met Arg Gly Cys Leu Arg Leu Ala Leu Leu Cys Ala Leu Pro Trp Leu 
1               5                   10                  15      


Leu Leu Ala Ala Ser Pro Gly His Pro Ala Lys Ser Pro Arg Gln Pro 
            20                  25                  30          


Pro Ala Pro Arg Arg Asp Pro Phe Asp Ala Ala Arg Gly Ala Asp Phe 
        35                  40                  45              


Asp His Val Tyr Ser Gly Val Val Asn Leu Ser Thr Glu Asn Ile Tyr 
    50                  55                  60                  


Ser Phe Asn Tyr Thr Ser Gln Pro Asp Gln Val Thr Ala Val Arg Val 
65                  70                  75                  80  


Tyr Val Asn Ser Ser Ser Glu Asn Leu Asn Tyr Pro Val Leu Val Val 
                85                  90                  95      


Val Arg Gln Gln Lys Glu Val Leu Ser Trp Gln Val Pro Leu Leu Phe 
            100                 105                 110         


Gln Gly Leu Tyr Gln Arg Ser Tyr Asn Tyr Gln Glu Val Ser Arg Thr 
        115                 120                 125             


Leu Cys Pro Ser Glu Ala Thr Asn Glu Thr Gly Pro Leu Gln Gln Leu 
    130                 135                 140                 


Ile Phe Val Asp Val Ala Ser Met Ala Pro Leu Gly Ala Gln Tyr Lys 
145                 150                 155                 160 


Leu Leu Val Thr Lys Leu Lys His Phe Gln Leu Arg Thr Asn Val Ala 
                165                 170                 175     


Phe His Phe Thr Ala Ser Pro Ser Gln Pro Gln Tyr Phe Leu Tyr Lys 
            180                 185                 190         


Phe Pro Lys Asp Val Asp Ser Val Ile Ile Lys Val Val Ser Glu Met 
        195                 200                 205             


Ala Tyr Pro Cys Ser Val Val Ser Val Gln Asn Ile Met Cys Pro Val 
    210                 215                 220                 


Tyr Asp Leu Asp His Asn Val Glu Phe Asn Gly Val Tyr Gln Ser Met 
225                 230                 235                 240 


Thr Lys Lys Ala Ala Ile Thr Leu Gln Lys Lys Asp Phe Pro Gly Glu 
                245                 250                 255     


Gln Phe Phe Val Val Phe Val Ile Lys Pro Glu Asp Tyr Ala Cys Gly 
            260                 265                 270         


Gly Ser Phe Phe Ile Gln Glu Lys Glu Asn Gln Thr Trp Asn Leu Gln 
        275                 280                 285             


Arg Lys Lys Asn Leu Glu Val Thr Ile Val Pro Ser Ile Lys Glu Ser 
    290                 295                 300                 


Val Tyr Val Lys Ser Ser Leu Phe Ser Val Phe Ile Phe Leu Ser Phe 
305                 310                 315                 320 


Tyr Leu Gly Cys Leu Leu Val Gly Phe Val His Tyr Leu Arg Phe Gln 
                325                 330                 335     


Arg Lys Ser Ile Asp Gly Ser Phe Gly Ser Asn Asp Gly Ser Gly Asn 
            340                 345                 350         


Met Val Ala Ser His Pro Ile Ala Ala Ser Thr Pro Glu Gly Ser Asn 
        355                 360                 365             


Tyr Gly Thr Ile Asp Glu Ser Ser Ser Ser Pro Gly Arg Gln Met Ser 
    370                 375                 380                 


Ser Ser Asp Gly Gly Pro Pro Gly Gln Ser Asp Thr Asp Ser Ser Val 
385                 390                 395                 400 


Glu Glu Ser Asp Phe Asp Thr Met Pro Asp Ile Glu Ser Asp Lys Asn 
                405                 410                 415     


Ile Ile Arg Thr Lys Met Phe Leu Tyr Leu Ser Asp Leu Ser Arg Lys 
            420                 425                 430         


Asp Arg Arg Ile Val Ser Lys Lys Tyr Lys Ile Tyr Phe Trp Asn Ile 
        435                 440                 445             


Ile Thr Ile Ala Val Phe Tyr Ala Leu Pro Val Ile Gln Leu Val Ile 
    450                 455                 460                 


Thr Tyr Gln Thr Val Val Asn Val Thr Gly Asn Gln Asp Ile Cys Tyr 
465                 470                 475                 480 


Tyr Asn Phe Leu Cys Ala His Pro Leu Gly Val Leu Ser Ala Phe Asn 
                485                 490                 495     


Asn Ile Leu Ser Asn Leu Gly His Val Leu Leu Gly Phe Leu Phe Leu 
            500                 505                 510         


Leu Ile Val Leu Arg Arg Asp Ile Leu His Arg Arg Ala Leu Glu Ala 
        515                 520                 525             


Lys Asp Ile Phe Ala Val Glu Tyr Gly Ile Pro Lys His Phe Gly Leu 
    530                 535                 540                 


Phe Tyr Ala Met Gly Ile Ala Leu Met Met Glu Gly Val Leu Ser Ala 
545                 550                 555                 560 


Cys Tyr His Val Cys Pro Asn Tyr Ser Asn Phe Gln Phe Asp Thr Ser 
                565                 570                 575     


Phe Met Tyr Met Ile Ala Gly Leu Cys Met Leu Lys Leu Tyr Gln Thr 
            580                 585                 590         


Arg His Pro Asp Ile Asn Ala Ser Ala Tyr Ser Ala Tyr Ala Ser Phe 
        595                 600                 605             


Ala Val Val Ile Met Val Thr Val Leu Gly Val Val Phe Gly Lys Asn 
    610                 615                 620                 


Asp Val Trp Phe Trp Val Ile Phe Ser Ala Ile His Val Leu Ala Ser 
625                 630                 635                 640 


Leu Ala Leu Ser Thr Gln Ile Tyr Tyr Met Gly Arg Phe Lys Ile Asp 
                645                 650                 655     


Leu Gly Ile Phe Arg Arg Ala Ala Met Val Phe Tyr Thr Asp Cys Ile 
            660                 665                 670         


Gln Gln Cys Ser Arg Pro Leu Tyr Met Asp Arg Met Val Leu Leu Val 
        675                 680                 685             


Val Gly Asn Leu Val Asn Trp Ser Phe Ala Leu Phe Gly Leu Ile Tyr 
    690                 695                 700                 


Arg Pro Arg Asp Phe Ala Ser Tyr Met Leu Gly Ile Phe Ile Cys Asn 
705                 710                 715                 720 


Leu Leu Leu Tyr Leu Ala Phe Tyr Ile Ile Met Lys Leu Arg Ser Ser 
                725                 730                 735     


Glu Lys Val Leu Pro Val Pro Leu Phe Cys Ile Val Ala Thr Ala Val 
            740                 745                 750         


Met Trp Ala Ala Ala Leu Tyr Phe Phe Phe Gln Asn Leu Ser Ser Trp 
        755                 760                 765             


Glu Gly Thr Pro Ala Glu Ser Arg Glu Lys Asn Arg Glu Cys Ile Leu 
    770                 775                 780                 


Leu Asp Phe Phe Asp Asp His Asp Ile Trp His Phe Leu Ser Ala Thr 
785                 790                 795                 800 


Ala Leu Phe Phe Ser Phe Leu Val Leu Leu Thr Leu Asp Asp Asp Leu 
                805                 810                 815     


Asp Val Val Arg Arg Asp Gln Ile Pro Val Phe 
            820                 825         

<210>  1702
<211>  1086
<212>  DNA
<213>  Homo sapiens

<400>  1702
ctcttggggg acgggctctt ttgctttcta tttcttctcc tgcagccagg gtgcacacgt     60

atttgaaaca gaccgaattt cctcctcgat gtggcgtcag gttgactttt cgagactagc    120

gggtatttct ttttaatgac tccaatgcct ttttattatt gctgttattg aggttgaggg    180

agaagagatc ggtctaaatt ctggctgggt aagtgggggg attctcggcg atgagaaacg    240

ggggacttag aagccggagg aaaatcagca gccccacatc tccacttctc cagtccgccc    300

tactctccac ccgtgacctc cagtggagac cccaggcggc agcatcagta tttgatcggc    360

ccttcgtcag cacgctgcca gccctggccg gctgggttcg ccaggcatca cccgctcggc    420

tctgaagcgg acgcctggcc ctgcaccggg ctttggaagg accctctctg cgctcgcccc    480

ctccccaggg tggctccgct ttcgagcccg ggcgcggtgc ccaccatgcg cggctgcctg    540

cggctcgcgc tgctctgcgc gctgccctgg ctcctgctgg cggcgtcgcc cgggcacccg    600

gcgaaatccc ccaggcagcc cccggcaccg cgccgcgacc ccttcgacgc tgccaggggc    660

gccgatttcg atcatgtcta cagcggggtg gtgaacctca gcaccgagaa catctactct    720

ttcaactaca ccagccagcc cgaccagatg gagtcttgtt ctgtcaccca ggttggagtg    780

caatggcacg atcttgactc actgcaacct ctgcctccca ggttcaagca attcacctgc    840

ctcagcctcc ccagtagctg ggattacagg tgacagccgt gagggtgtat gtgaacagtt    900

cctctgagaa tctcaactac ccggtccttg ttgtggttcg ccagcagaaa gaggtgctgt    960

cctggcaggt tcctctgctc ttccaaggac tataccagag gagctacaac tatcaagaag   1020

tgagccgcac cttatgtccc tcagaagcaa ccaatgagac gggacccttg cagcaactga   1080

tatttg                                                              1086


<210>  1703
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  1703


Met Arg Gly Cys Leu Arg Leu Ala Leu Leu Cys Ala Leu Pro Trp Leu 
1               5                   10                  15      


Leu Leu Ala Ala Ser Pro Gly His Pro Ala Lys Ser Pro Arg Gln Pro 
            20                  25                  30          


Pro Ala Pro Arg Arg Asp Pro Phe Asp Ala Ala Arg Gly Ala Asp Phe 
        35                  40                  45              


Asp His Val Tyr Ser Gly Val Val Asn Leu Ser Thr Glu Asn Ile Tyr 
    50                  55                  60                  


Ser Phe Asn Tyr Thr Ser Gln Pro Asp Gln Met Glu Ser Cys Ser Val 
65                  70                  75                  80  


Thr Gln Val Gly Val Gln Trp His Asp Leu Asp Ser Leu Gln Pro Leu 
                85                  90                  95      


Pro Pro Arg Phe Lys Gln Phe Thr Cys Leu Ser Leu Pro Ser Ser Trp 
            100                 105                 110         


Asp Tyr Arg 
        115 

<210>  1704
<211>  1010
<212>  DNA
<213>  Homo sapiens

<400>  1704
gtggaggatc tttcttcatc caggaaaagg aaaaccagac ctggaatcta cagcgaaaaa     60

agaaccttga agtgaccatt gtcccttcca ttaaagaatc tgtttatgtg aaatccagtc    120

ttttcagtgt cttcatcttc ctgtccttct acttgggatg ccttcttgtt gggtttgttc    180

attatctgag gtttcagaga aaatccattg atggaagctt tgggtccaat gatggctctg    240

gaaatatggt ggcatctcat cccattgctg ccagcacacc cgaagggagc aattatggga    300

caataggtat gtcctaccag gtctgttcat gaaagtgttt cctaattctg cagagaatat    360

gatagaaagg cattccagcc actaataact gggaatgtgg gcaaagcagc tatcctatga    420

gattgtcttt tatttgtaag atgagttgct tggagatttg gaagcttcct cccagctcta    480

actttctcca gttctgttgt tctgtttctt ggatctgcta gccccacttg ggcagaattc    540

cttcaatgtt tgccatctaa tactaaggcc ccctagggac tttttcatat ccagcccggg    600

tttagggcat gaaagatgtg tcccagggag cctgacatca attgaccagt tgtttcattc    660

tcaggtttca gtggagtaag gggcgatcag aagactgagg cagtgctgca ggtgaacatg    720

gctgtagcct accaatcctt cattttggct gacttcataa ttgaacctgc tcactgccac    780

ccagtcgttc acatggcaaa ccccagtgtt ccttaagtgg gctgaaaaga atggaatcct    840

agacctgtct tgttagagta gaagctcatt gagctgcctg cccttccata ttgcttgtgg    900

acctatgaat ggtgctcttt aaaatgtcag tgtagaggga ctgggaatcc tgtattcctg    960

ccctatcatt ctgtaacttt gagaagcatg tgggctcagt gcagactact              1010


<210>  1705
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  1705


Met Glu Ala Leu Gly Pro Met Met Ala Leu Glu Ile Trp Trp His Leu 
1               5                   10                  15      


Ile Pro Leu Leu Pro Ala His Pro Lys Gly Ala Ile Met Gly Gln 
            20                  25                  30      

<210>  1706
<211>  3508
<212>  DNA
<213>  Homo sapiens

<400>  1706
agccacgtgg cggcggggcg gggaccgggc gggccgggcg ctgggagctg gctgtcccag     60

gagcagagca gtctccctgt ccagatcacc aggatccctg cttgctggag aatgacccag    120

atgtcccagg tgcaggagct cttccatgag gcagcccagc aggatgccct ggcccagccc    180

cagccctggt ggaagaccca gctgttcatg tgggagcctg tgctgtttgg gacctgggat    240

ggtgtgttca catcctgcat gatcaacatc tttggggttg tgctcttcct gaggactggc    300

tggctggtgg gaaacacagg agtgctcctg ggcatgttcc tggtgtcctt cgtcatcctg    360

gtggccctcg tcacggtgct gtctggcatt ggcgtcgggg agcgcagcag catcggcagc    420

ggtggcgtct actccatgat ctcctcggtc ctgggtgggc agacgggagg caccatcggg    480

ctgctctatg tgtttggaca gtgtgttgca ggtgccatgt atatcaccgg ctttgctgaa    540

tccatctcgg atttgctggg cctcgggaat atctgggctg tgcgaggaat ttcagttgcg    600

gtgcttctgg ccttgctggg cattaacctc gcaggtgtca aatggataat ccgcctccag    660

ctgctgttgc tgttcctgct ggccgtgtcc acactggact ttgtggtggg ttctttcacc    720

cacctggacc cagaacatgg tttcattgga tattcacccg aactgctaca gaacaacacg    780

ctgcccgatt acagcccggg ggaatctttt ttcactgtct ttggggtttt cttcccagcg    840

gctacaggag tcatggccgg cttcaacatg gggggcgacc tcagggagcc tgccgccagc    900

attcccccgg gctccctggc agctgttggc atctcgtggt ttctgtacat catcttcgtc    960

ttcctcctgg gcgccatctg cactcgagag gcccttcgct atgacttcct gatagcggaa   1020

aaggtatccc tcatgggctt cctgttcctt ttgggcttat acatctcgtc cctggcttcc   1080

tgcatgggag gactttatgg agctccccgc atcctgcagt gcattgccca ggagaaagtg   1140

atccctgcac ttgcctgtct gggacaaggg aaggggccaa acaaaacacc cgtggctgcc   1200

atctgcctga ccagcttggt gaccatggcc tttgtttttg tgggtcaagt gaacgttctg   1260

gcccccatcg tcaccatcaa cttcatgctg acatacgttg cagtggacta ctcttacttc   1320

tccctgtcca tgtgttcctg cagcctgacc ccggtgcctg agccggtgct cagggagggc   1380

gcagaaggcc tccactgctc tgagcacctg ctcttagaga aagctcccag ttacggctct   1440

gagggacctg cccaaagagt cttggagggc acgctactgg aattcaccaa ggacatggat   1500

cagctcctcc agctaaccag gaagcttgag agtagccagc ccaggcaagg agagggtaac   1560

aggaccccag aaagtcagaa gaggaaaagc aagaaggcca ccaagcagac cctacaagat   1620

agcttcctct tggacctcaa atcccctcct tctttccctg tcgagatctc tgacaggttg   1680

cccgctgcct cctgggaggg gcaggagtcc tgctggaaca agcagacttc caagagcgaa   1740

gggactcagc ctgagggaac atatggagag caacttgttc ctgagctgtg caaccaatca   1800

gagtccagtg gagaagattt cttcctgaag tccaggctcc aagaacaaga tgtctggaga   1860

agatccactt ctttctatac ccacatgtgc aacccctggg tctccctgtt gggggctgtt   1920

gggtcccttc tcatcatgtt tgtgatacag tgggtgtata ccctggttaa catgggtgtt   1980

gctgccatcg tgtatttcta cattggccgg gccagtccag ggcttcacct tggatcagcc   2040

tccaacttca gctttttccg gtggatgagg tctctcttgc tcccctcctg caggagcttg   2100

cggtcccctc aggagcagat catcttggcg ccgtccctgg ctaaggttga catggagatg   2160

actcagctca cccaggagaa tgcagacttc gccactcggg atcgctacca ccactcctcc   2220

ctcgtgaacc gggagcagct gatgcctcac tactagatgc agtgctggga ccttcctctt   2280

ttggagctgt cccatgtaca gtggacccaa gctcaggacc ttcgtggagc tgcttctcca   2340

acctgagaaa ctcaagaccc atcctcccgc tgtcactttg gacaatggaa atctacattt   2400

tcttttccct tttttttttt ttttgagaca gagtctcgcc ctgtcaccca ggctggagtc   2460

cagtggcaca atcttggctc actgcaacct ctgcttcccg agttcaagca attctcctgc   2520

ctcagcctcc tgagtagctg ggattatagg catgcaccac cacacccagc tattttttgt   2580

atttttactg gagacagggt ttcaccatgt tggccaggct ggtctcgaac tcctgacctc   2640

gtgatccacc cgtctcagcc tcccaaagta ctgggattac aggcgtgagc caccatgcct   2700

ggccagaaat ctatgttttc ttagaacatg tggaagaagg aaaaagacaa aaaaggaaat   2760

ctggattctg aggaccacgt ctcacccagg gtgacatcag gaatggtgct agcctctgca   2820

acacgacacc cagtctgaag agctctatac aggtactaag actagcaggg gacaccaaga   2880

ctctgcacaa ccagattgct tgtgcagagg gccacaataa gtgtatgttt tatattttat   2940

tgtattattt attcaaaaat aaataataca ctcacatgtt tccacaccca aaagatatat   3000

agagtgaaaa gtctccctcc aatccttatt ctccacctgc tcagttcctg tctaccctgg   3060

cctagaggta accactattc tcatccgtac atccagcatt tctttatgga tatacaagca   3120

aatgggaatg tagagtctca cattctctct ttatacacaa aagttagcac gttatacaca   3180

tgttctgcac cttgcttttt tcccttaaca atctatcttg gagacatttc atatcaattc   3240

atatgccatt tgttcatttt tttcattgta taaatgtgtt ataatttatt tcgccagttc   3300

cacaatgatg agcatttgga ttctttccaa tcttttgcaa tgacaatcag ctctgcagtg   3360

aataatcttg tacaaatgtg caagcataaa gtgtatctct aggataaatt cccaaaagtg   3420

gaattgcagg atcaaaaggt acatgcattt gtaaactatt attgtttagt gagggtcttt   3480

ttaattaaag aattaacatg aattgcct                                      3508


<210>  1707
<211>  714
<212>  PRT
<213>  Homo sapiens

<400>  1707


Met Thr Gln Met Ser Gln Val Gln Glu Leu Phe His Glu Ala Ala Gln 
1               5                   10                  15      


Gln Asp Ala Leu Ala Gln Pro Gln Pro Trp Trp Lys Thr Gln Leu Phe 
            20                  25                  30          


Met Trp Glu Pro Val Leu Phe Gly Thr Trp Asp Gly Val Phe Thr Ser 
        35                  40                  45              


Cys Met Ile Asn Ile Phe Gly Val Val Leu Phe Leu Arg Thr Gly Trp 
    50                  55                  60                  


Leu Val Gly Asn Thr Gly Val Leu Leu Gly Met Phe Leu Val Ser Phe 
65                  70                  75                  80  


Val Ile Leu Val Ala Leu Val Thr Val Leu Ser Gly Ile Gly Val Gly 
                85                  90                  95      


Glu Arg Ser Ser Ile Gly Ser Gly Gly Val Tyr Ser Met Ile Ser Ser 
            100                 105                 110         


Val Leu Gly Gly Gln Thr Gly Gly Thr Ile Gly Leu Leu Tyr Val Phe 
        115                 120                 125             


Gly Gln Cys Val Ala Gly Ala Met Tyr Ile Thr Gly Phe Ala Glu Ser 
    130                 135                 140                 


Ile Ser Asp Leu Leu Gly Leu Gly Asn Ile Trp Ala Val Arg Gly Ile 
145                 150                 155                 160 


Ser Val Ala Val Leu Leu Ala Leu Leu Gly Ile Asn Leu Ala Gly Val 
                165                 170                 175     


Lys Trp Ile Ile Arg Leu Gln Leu Leu Leu Leu Phe Leu Leu Ala Val 
            180                 185                 190         


Ser Thr Leu Asp Phe Val Val Gly Ser Phe Thr His Leu Asp Pro Glu 
        195                 200                 205             


His Gly Phe Ile Gly Tyr Ser Pro Glu Leu Leu Gln Asn Asn Thr Leu 
    210                 215                 220                 


Pro Asp Tyr Ser Pro Gly Glu Ser Phe Phe Thr Val Phe Gly Val Phe 
225                 230                 235                 240 


Phe Pro Ala Ala Thr Gly Val Met Ala Gly Phe Asn Met Gly Gly Asp 
                245                 250                 255     


Leu Arg Glu Pro Ala Ala Ser Ile Pro Pro Gly Ser Leu Ala Ala Val 
            260                 265                 270         


Gly Ile Ser Trp Phe Leu Tyr Ile Ile Phe Val Phe Leu Leu Gly Ala 
        275                 280                 285             


Ile Cys Thr Arg Glu Ala Leu Arg Tyr Asp Phe Leu Ile Ala Glu Lys 
    290                 295                 300                 


Val Ser Leu Met Gly Phe Leu Phe Leu Leu Gly Leu Tyr Ile Ser Ser 
305                 310                 315                 320 


Leu Ala Ser Cys Met Gly Gly Leu Tyr Gly Ala Pro Arg Ile Leu Gln 
                325                 330                 335     


Cys Ile Ala Gln Glu Lys Val Ile Pro Ala Leu Ala Cys Leu Gly Gln 
            340                 345                 350         


Gly Lys Gly Pro Asn Lys Thr Pro Val Ala Ala Ile Cys Leu Thr Ser 
        355                 360                 365             


Leu Val Thr Met Ala Phe Val Phe Val Gly Gln Val Asn Val Leu Ala 
    370                 375                 380                 


Pro Ile Val Thr Ile Asn Phe Met Leu Thr Tyr Val Ala Val Asp Tyr 
385                 390                 395                 400 


Ser Tyr Phe Ser Leu Ser Met Cys Ser Cys Ser Leu Thr Pro Val Pro 
                405                 410                 415     


Glu Pro Val Leu Arg Glu Gly Ala Glu Gly Leu His Cys Ser Glu His 
            420                 425                 430         


Leu Leu Leu Glu Lys Ala Pro Ser Tyr Gly Ser Glu Gly Pro Ala Gln 
        435                 440                 445             


Arg Val Leu Glu Gly Thr Leu Leu Glu Phe Thr Lys Asp Met Asp Gln 
    450                 455                 460                 


Leu Leu Gln Leu Thr Arg Lys Leu Glu Ser Ser Gln Pro Arg Gln Gly 
465                 470                 475                 480 


Glu Gly Asn Arg Thr Pro Glu Ser Gln Lys Arg Lys Ser Lys Lys Ala 
                485                 490                 495     


Thr Lys Gln Thr Leu Gln Asp Ser Phe Leu Leu Asp Leu Lys Ser Pro 
            500                 505                 510         


Pro Ser Phe Pro Val Glu Ile Ser Asp Arg Leu Pro Ala Ala Ser Trp 
        515                 520                 525             


Glu Gly Gln Glu Ser Cys Trp Asn Lys Gln Thr Ser Lys Ser Glu Gly 
    530                 535                 540                 


Thr Gln Pro Glu Gly Thr Tyr Gly Glu Gln Leu Val Pro Glu Leu Cys 
545                 550                 555                 560 


Asn Gln Ser Glu Ser Ser Gly Glu Asp Phe Phe Leu Lys Ser Arg Leu 
                565                 570                 575     


Gln Glu Gln Asp Val Trp Arg Arg Ser Thr Ser Phe Tyr Thr His Met 
            580                 585                 590         


Cys Asn Pro Trp Val Ser Leu Leu Gly Ala Val Gly Ser Leu Leu Ile 
        595                 600                 605             


Met Phe Val Ile Gln Trp Val Tyr Thr Leu Val Asn Met Gly Val Ala 
    610                 615                 620                 


Ala Ile Val Tyr Phe Tyr Ile Gly Arg Ala Ser Pro Gly Leu His Leu 
625                 630                 635                 640 


Gly Ser Ala Ser Asn Phe Ser Phe Phe Arg Trp Met Arg Ser Leu Leu 
                645                 650                 655     


Leu Pro Ser Cys Arg Ser Leu Arg Ser Pro Gln Glu Gln Ile Ile Leu 
            660                 665                 670         


Ala Pro Ser Leu Ala Lys Val Asp Met Glu Met Thr Gln Leu Thr Gln 
        675                 680                 685             


Glu Asn Ala Asp Phe Ala Thr Arg Asp Arg Tyr His His Ser Ser Leu 
    690                 695                 700                 


Val Asn Arg Glu Gln Leu Met Pro His Tyr 
705                 710                 

<210>  1708
<211>  2828
<212>  DNA
<213>  Homo sapiens

<400>  1708
agttgccagg ggagattgaa aagcagccta tgcgcagagc tgcagctgga gggcttgcgg     60

tgggacagct tccaggagag ggtcccgcag gagaggaagg ggcagccctg gggaaggcga    120

tgcgtggagg aggctgctca ccccattccc catctgggtg tctttcagga gtcatggccg    180

gcttcaacat ggggggcgac ctcagggagc ctgccgccag cattcccccg ggctccctgg    240

cagctgttgg catctcgtgg tttctgtaca tcatcttcgt cttcctcctg ggcgccatct    300

gcactcgaga ggcccttcgc tatgacttcc tgatagcgga aaaggtatcc ctcatgggct    360

tcctgttcct tttgggctta tacatctcgt ccctggcttc ctgcatggga ggactttatg    420

gagctccccg catcctgcag tgcattgccc aggagaaagt gatccctgca cttgcctgtc    480

tgggacaagg gaaggggcca aacaaaacac ccgtggctgc catctgcctg accagcttgg    540

tgaccatggc ctttgttttt gtgggtcaag tgaacgttct ggcccccatc gtcaccatca    600

acttcatgct gacatacgtt gcagtggact actcttactt ctccctgtcc atgtgttcct    660

gcagcctgac cccggtgcct gagccggtgc tcagggaggg cgcagaaggc ctccactgct    720

ctgagcacct gctcttagag aaagctccca gttacggctc tgagggacct gcccaaagag    780

tcttggaggg cacgctactg gaattcacca aggacatgga tcagctcctc cagctaacca    840

ggaagcttga gagtagccag cccaggcaag gagagggtaa caggacccca gaaagtcaga    900

agaggaaaag caagaaggcc accaagcaga ccctacaaga tagcttcctc ttggacctca    960

aatcccctcc ttctttccct gtcgagatct ctgacaggtt gcccgctgcc tcctgggagg   1020

ggcaggagtc ctgctggaac aagcagactt ccaagagcga agggactcag cctgagggaa   1080

catatggaga gcaacttgtt cctgagctgt gcaaccaatc agagtccagt ggagaagatt   1140

tcttcctgaa gtccaggctc caagaacaag atgtctggag aagatccact tctttctata   1200

cccacatgtg caacccctgg gtctccctgt tgggggctgt tgggtccctt ctcatcatgt   1260

ttgtgataca gtgggtgtat accctggtta acatgggtgt tgctgccatc gtgtatttct   1320

acattggccg ggccagtcca gggcttcacc ttggatcagc ctccaacttc agctttttcc   1380

ggtggatgag gtctctcttg ctcccctcct gcaggagctt gcggtcccct caggagcaga   1440

tcatcttggc gccgtccctg gctaaggttg acatggagat gactcagctc acccaggaga   1500

atgcagactt cgccactcgg gatcgctacc accactcctc cctcgtgaac cgggagcagc   1560

tgatgcctca ctactagatg cagtgctggg accttcctct tttggagctg tcccatgtac   1620

agtggaccca agctcaggac cttcgtggag ctgcttctcc aacctgagaa actcaagacc   1680

catcctcccg ctgtcacttt ggacaatgga aatctacatt ttcttttccc tttttttttt   1740

tttttgagac agagtctcgc cctgtcaccc aggctggagt ccagtggcac aatcttggct   1800

cactgcaacc tctgcttccc gagttcaagc aattctcctg cctcagcctc ctgagtagct   1860

gggattatag gcatgcacca ccacacccag ctattttttg tatttttact ggagacaggg   1920

tttcaccatg ttggccaggc tggtctcgaa ctcctgacct cgtgatccac ccgtctcagc   1980

ctcccaaagt actgggatta caggcgtgag ccaccatgcc tggccagaaa tctatgtttt   2040

cttagaacat gtggaagaag gaaaaagaca aaaaaggaaa tctggattct gaggaccacg   2100

tctcacccag ggtgacatca ggaatggtgc tagcctctgc aacacgacac ccagtctgaa   2160

gagctctata caggtactaa gactagcagg ggacaccaag actctgcaca accagattgc   2220

ttgtgcagag ggccacaata agtgtatgtt ttatatttta ttgtattatt tattcaaaaa   2280

taaataatac actcacatgt ttccacaccc aaaagatata tagagtgaaa agtctccctc   2340

caatccttat tctccacctg ctcagttcct gtctaccctg gcctagaggt aaccactatt   2400

ctcatccgta catccagcat ttctttatgg atatacaagc aaatgggaat gtagagtctc   2460

acattctctc tttatacaca aaagttagca cgttatacac atgttctgca ccttgctttt   2520

ttcccttaac aatctatctt ggagacattt catatcaatt catatgccat ttgttcattt   2580

ttttcattgt ataaatgtgt tataatttat ttcgccagtt ccacaatgat gagcatttgg   2640

attctttcca atcttttgca atgacaatca gctctgcagt gaataatctt gtacaaatgt   2700

gcaagcataa agtgtatctc taggataaat tcccaaaagt ggaattgcag gatcaaaagg   2760

tacatgcatt tgtaaactat tattgtttag tgagggtctt tttaattaaa gaattaacat   2820

gaattgcc                                                            2828


<210>  1709
<211>  515
<212>  PRT
<213>  Homo sapiens

<400>  1709


Met Arg Arg Ala Ala Ala Gly Gly Leu Ala Val Gly Gln Leu Pro Gly 
1               5                   10                  15      


Glu Gly Pro Ala Gly Glu Glu Gly Ala Ala Leu Gly Lys Ala Met Arg 
            20                  25                  30          


Gly Gly Gly Cys Ser Pro His Ser Pro Ser Gly Cys Leu Ser Gly Val 
        35                  40                  45              


Met Ala Gly Phe Asn Met Gly Gly Asp Leu Arg Glu Pro Ala Ala Ser 
    50                  55                  60                  


Ile Pro Pro Gly Ser Leu Ala Ala Val Gly Ile Ser Trp Phe Leu Tyr 
65                  70                  75                  80  


Ile Ile Phe Val Phe Leu Leu Gly Ala Ile Cys Thr Arg Glu Ala Leu 
                85                  90                  95      


Arg Tyr Asp Phe Leu Ile Ala Glu Lys Val Ser Leu Met Gly Phe Leu 
            100                 105                 110         


Phe Leu Leu Gly Leu Tyr Ile Ser Ser Leu Ala Ser Cys Met Gly Gly 
        115                 120                 125             


Leu Tyr Gly Ala Pro Arg Ile Leu Gln Cys Ile Ala Gln Glu Lys Val 
    130                 135                 140                 


Ile Pro Ala Leu Ala Cys Leu Gly Gln Gly Lys Gly Pro Asn Lys Thr 
145                 150                 155                 160 


Pro Val Ala Ala Ile Cys Leu Thr Ser Leu Val Thr Met Ala Phe Val 
                165                 170                 175     


Phe Val Gly Gln Val Asn Val Leu Ala Pro Ile Val Thr Ile Asn Phe 
            180                 185                 190         


Met Leu Thr Tyr Val Ala Val Asp Tyr Ser Tyr Phe Ser Leu Ser Met 
        195                 200                 205             


Cys Ser Cys Ser Leu Thr Pro Val Pro Glu Pro Val Leu Arg Glu Gly 
    210                 215                 220                 


Ala Glu Gly Leu His Cys Ser Glu His Leu Leu Leu Glu Lys Ala Pro 
225                 230                 235                 240 


Ser Tyr Gly Ser Glu Gly Pro Ala Gln Arg Val Leu Glu Gly Thr Leu 
                245                 250                 255     


Leu Glu Phe Thr Lys Asp Met Asp Gln Leu Leu Gln Leu Thr Arg Lys 
            260                 265                 270         


Leu Glu Ser Ser Gln Pro Arg Gln Gly Glu Gly Asn Arg Thr Pro Glu 
        275                 280                 285             


Ser Gln Lys Arg Lys Ser Lys Lys Ala Thr Lys Gln Thr Leu Gln Asp 
    290                 295                 300                 


Ser Phe Leu Leu Asp Leu Lys Ser Pro Pro Ser Phe Pro Val Glu Ile 
305                 310                 315                 320 


Ser Asp Arg Leu Pro Ala Ala Ser Trp Glu Gly Gln Glu Ser Cys Trp 
                325                 330                 335     


Asn Lys Gln Thr Ser Lys Ser Glu Gly Thr Gln Pro Glu Gly Thr Tyr 
            340                 345                 350         


Gly Glu Gln Leu Val Pro Glu Leu Cys Asn Gln Ser Glu Ser Ser Gly 
        355                 360                 365             


Glu Asp Phe Phe Leu Lys Ser Arg Leu Gln Glu Gln Asp Val Trp Arg 
    370                 375                 380                 


Arg Ser Thr Ser Phe Tyr Thr His Met Cys Asn Pro Trp Val Ser Leu 
385                 390                 395                 400 


Leu Gly Ala Val Gly Ser Leu Leu Ile Met Phe Val Ile Gln Trp Val 
                405                 410                 415     


Tyr Thr Leu Val Asn Met Gly Val Ala Ala Ile Val Tyr Phe Tyr Ile 
            420                 425                 430         


Gly Arg Ala Ser Pro Gly Leu His Leu Gly Ser Ala Ser Asn Phe Ser 
        435                 440                 445             


Phe Phe Arg Trp Met Arg Ser Leu Leu Leu Pro Ser Cys Arg Ser Leu 
    450                 455                 460                 


Arg Ser Pro Gln Glu Gln Ile Ile Leu Ala Pro Ser Leu Ala Lys Val 
465                 470                 475                 480 


Asp Met Glu Met Thr Gln Leu Thr Gln Glu Asn Ala Asp Phe Ala Thr 
                485                 490                 495     


Arg Asp Arg Tyr His His Ser Ser Leu Val Asn Arg Glu Gln Leu Met 
            500                 505                 510         


Pro His Tyr 
        515 

<210>  1710
<211>  1697
<212>  DNA
<213>  Homo sapiens

<400>  1710
tgcaatccat atgaaatgtg gtggtggatt cagctgaaac catggaatga atgggggcga     60

ggctggggat gtggaaactg tatcccaggg atcagatcta gacgactcag tggatgattg    120

catggggtgc aggtgggtgg gtgctggggg ggtagaaagg cacaggagca ggttctggca    180

ctggcgaatg aaaccgcttc tcacacaggt atccctcatg ggcttcctgt tccttttggg    240

cttatacatc tcgtccctgg cttcctgcat gggaggactt tatggagctc cccgcatcct    300

gcagtgcatt gcccaggaga aagtgatccc tgcacttgcc tgtctgggac aagggatctc    360

tgacaggttg cccgctgcct cctgggaggg gcaggagtcc tgctggaaca agcagattcg    420

ccactcggga tcgctaccac cactcctccc tcgtgaaccg ggagcagctg atgcctcact    480

actagatgca gtgctgggac cttcctcttt tggagctgtc ccatgtacag tggacccaag    540

ctcaggacct tcgtggagct gcttctccaa cctgagaaac tcaagaccca tcctcccgct    600

gtcactttgg acaatggaaa tctacatttt cttttccctt tttttttttt tttgagacag    660

agtctcgccc tgtcacccag gctggagtcc agtggcacaa tcttggctca ctgcaacctc    720

tgcttcccga gttcaagcaa ttctcctgcc tcagcctcct gagtagctgg gattataggc    780

atgcaccacc acacccagct attttttgta tttttactgg agacagggtt tcaccatgtt    840

ggccaggctg gtctcgaact cctgacctcg tgatccaccc gtctcagcct cccaaagtac    900

tgggattaca ggcgtgagcc accatgcctg gccagaaatc tatgttttct tagaacatgt    960

ggaagaagga aaaagacaaa aaaggaaatc tggattctga ggaccacgtc tcacccaggg   1020

tgacatcagg aatggtgcta gcctctgcaa cacgacaccc agtctgaaga gctctataca   1080

ggtactaaga ctagcagggg acaccaagac tctgcacaac cagattgctt gtgcagaggg   1140

ccacaataag tgtatgtttt atattttatt gtattattta ttcaaaaata aataatacac   1200

tcacatgttt ccacacccaa aagatatata gagtgaaaag tctccctcca atccttattc   1260

tccacctgct cagttcctgt ctaccctggc ctagaggtaa ccactattct catccgtaca   1320

tccagcattt ctttatggat atacaagcaa atgggaatgt agagtctcac attctctctt   1380

tatacacaaa agttagcacg ttatacacat gttctgcacc ttgctttttt cccttaacaa   1440

tctatcttgg agacatttca tatcaattca tatgccattt gttcattttt ttcattgtat   1500

aaatgtgtta taatttattt cgccagttcc acaatgatga gcatttggat tctttccaat   1560

cttttgcaat gacaatcagc tctgcagtga ataatcttgt acaaatgtgc aagcataaag   1620

tgtatctcta ggataaattc ccaaaagtgg aattgcagga tcaaaaggta catgcatttg   1680

taaactatta ttgttta                                                  1697


<210>  1711
<211>  202
<212>  PRT
<213>  Homo sapiens

<400>  1711


Met Asn Gly Gly Glu Ala Gly Asp Val Glu Thr Val Ser Gln Gly Ser 
1               5                   10                  15      


Asp Leu Asp Asp Ser Val Asp Asp Cys Met Gly Cys Arg Trp Val Gly 
            20                  25                  30          


Ala Gly Gly Val Glu Arg His Arg Ser Arg Phe Trp His Trp Arg Met 
        35                  40                  45              


Lys Pro Leu Leu Thr Gln Val Ser Leu Met Gly Phe Leu Phe Leu Leu 
    50                  55                  60                  


Gly Leu Tyr Ile Ser Ser Leu Ala Ser Cys Met Gly Gly Leu Tyr Gly 
65                  70                  75                  80  


Ala Pro Arg Ile Leu Gln Cys Ile Ala Gln Glu Lys Val Ile Pro Ala 
                85                  90                  95      


Leu Ala Cys Leu Gly Gln Gly Ile Ser Asp Arg Leu Pro Ala Ala Ser 
            100                 105                 110         


Trp Glu Gly Gln Glu Ser Cys Trp Asn Lys Gln Ile Arg His Ser Gly 
        115                 120                 125             


Ser Leu Pro Pro Leu Leu Pro Arg Glu Pro Gly Ala Ala Asp Ala Ser 
    130                 135                 140                 


Leu Leu Asp Ala Val Leu Gly Pro Ser Ser Phe Gly Ala Val Pro Cys 
145                 150                 155                 160 


Thr Val Asp Pro Ser Ser Gly Pro Ser Trp Ser Cys Phe Ser Asn Leu 
                165                 170                 175     


Arg Asn Ser Arg Pro Ile Leu Pro Leu Ser Leu Trp Thr Met Glu Ile 
            180                 185                 190         


Tyr Ile Phe Phe Ser Leu Phe Phe Phe Phe 
        195                 200         

<210>  1712
<211>  2203
<212>  DNA
<213>  Homo sapiens

<400>  1712
ctgccatgca agacgtgact ttgcttctcc ttccccttct gccatgattt gtgatgcctc     60

ctcagccatg tggaactgag tcatggccgg cttcaacatg gggggcgacc tcagggagcc    120

tgccgccagc attcccccgg gctccctggc agctgttggc atctcgtggt ttctgtacat    180

catcttcgtc ttcctcctgg gcgccatctg cactcgagag gcccttcgct atgacttcct    240

gatagcggaa aaggtatccc tcatgggctt cctgttcctt ttgggcttat acatctcgtc    300

cctggcttcc tgcatgggag gactttatgg agctccccgc atcctgcagt gcattgccca    360

ggagaaagtg atccctgcac ttgcctgtct gggacaaggg atctctgaca ggttgcccgc    420

tgcctcctgg gaggggcagg agtcctgctg gaacaagcag acttccaaga gcgaagggac    480

tcagcctgag ggaacatatg gagagcaact tgttcctgag ctgtgcaacc aatcagagtc    540

cagtggagaa gatttcttcc tgaagtccag gctccaagaa caagatgtct ggagaagatc    600

cacttctttc tatacccaca tgtgcaaccc ctgggtctcc ctgttggggg ctgttgggtc    660

ccttctcatc atgtttgtga tacagtgggt gtataccctg gttaacatgg gtgttgctgc    720

catcgtgtat ttctacattg gccgggccag tccagggctt caccttggat cagcctccaa    780

cttcagcttt ttccggtgga tgaggtctct cttgctcccc tcctgcagga gcttgcggtc    840

ccctcaggag cagatcatct tggcgccgtc cctggctaag gttgacatgg agatgactca    900

gctcacccag gagaatgcag acttcgccac tcgggatcgc taccaccact cctccctcgt    960

gaaccgggag cagctgatgc ctcactacta gatgcagtgc tgggaccttc ctcttttgga   1020

gctgtcccat gtacagtgga cccaagctca ggaccttcgt ggagctgctt ctccaacctg   1080

agaaactcaa gacccatcct cccgctgtca ctttggacaa tggaaatcta cattttcttt   1140

tccctttttt tttttttttg agacagagtc tcgccctgtc acccaggctg gagtccagtg   1200

gcacaatctt ggctcactgc aacctctgct tcccgagttc aagcaattct cctgcctcag   1260

cctcctgagt agctgggatt ataggcatgc accaccacac ccagctattt tttgtatttt   1320

tactggagac agggtttcac catgttggcc aggctggtct cgaactcctg acctcgtgat   1380

ccacccgtct cagcctccca aagtactggg attacaggcg tgagccacca tgcctggcca   1440

gaaatctatg ttttcttaga acatgtggaa gaaggaaaaa gacaaaaaag gaaatctgga   1500

ttctgaggac cacgtctcac ccagggtgac atcaggaatg gtgctagcct ctgcaacacg   1560

acacccagtc tgaagagctc tatacaggta ctaagactag caggggacac caagactctg   1620

cacaaccaga ttgcttgtgc agagggccac aataagtgta tgttttatat tttattgtat   1680

tatttattca aaaataaata atacactcac atgtttccac acccaaaaga tatatagagt   1740

gaaaagtctc cctccaatcc ttattctcca cctgctcagt tcctgtctac cctggcctag   1800

aggtaaccac tattctcatc cgtacatcca gcatttcttt atggatatac aagcaaatgg   1860

gaatgtagag tctcacattc tctctttata cacaaaagtt agcacgttat acacatgttc   1920

tgcaccttgc ttttttccct taacaatcta tcttggagac atttcatatc aattcatatg   1980

ccatttgttc atttttttca ttgtataaat gtgttataat ttatttcgcc agttccacaa   2040

tgatgagcat ttggattctt tccaatcttt tgcaatgaca atcagctctg cagtgaataa   2100

tcttgtacaa atgtgcaagc ataaagtgta tctctaggat aaattcccaa aagtggaatt   2160

gcaggatcaa aaggtacatg catttgtaaa ctattattgt tta                     2203


<210>  1713
<211>  302
<212>  PRT
<213>  Homo sapiens

<400>  1713


Met Ala Gly Phe Asn Met Gly Gly Asp Leu Arg Glu Pro Ala Ala Ser 
1               5                   10                  15      


Ile Pro Pro Gly Ser Leu Ala Ala Val Gly Ile Ser Trp Phe Leu Tyr 
            20                  25                  30          


Ile Ile Phe Val Phe Leu Leu Gly Ala Ile Cys Thr Arg Glu Ala Leu 
        35                  40                  45              


Arg Tyr Asp Phe Leu Ile Ala Glu Lys Val Ser Leu Met Gly Phe Leu 
    50                  55                  60                  


Phe Leu Leu Gly Leu Tyr Ile Ser Ser Leu Ala Ser Cys Met Gly Gly 
65                  70                  75                  80  


Leu Tyr Gly Ala Pro Arg Ile Leu Gln Cys Ile Ala Gln Glu Lys Val 
                85                  90                  95      


Ile Pro Ala Leu Ala Cys Leu Gly Gln Gly Ile Ser Asp Arg Leu Pro 
            100                 105                 110         


Ala Ala Ser Trp Glu Gly Gln Glu Ser Cys Trp Asn Lys Gln Thr Ser 
        115                 120                 125             


Lys Ser Glu Gly Thr Gln Pro Glu Gly Thr Tyr Gly Glu Gln Leu Val 
    130                 135                 140                 


Pro Glu Leu Cys Asn Gln Ser Glu Ser Ser Gly Glu Asp Phe Phe Leu 
145                 150                 155                 160 


Lys Ser Arg Leu Gln Glu Gln Asp Val Trp Arg Arg Ser Thr Ser Phe 
                165                 170                 175     


Tyr Thr His Met Cys Asn Pro Trp Val Ser Leu Leu Gly Ala Val Gly 
            180                 185                 190         


Ser Leu Leu Ile Met Phe Val Ile Gln Trp Val Tyr Thr Leu Val Asn 
        195                 200                 205             


Met Gly Val Ala Ala Ile Val Tyr Phe Tyr Ile Gly Arg Ala Ser Pro 
    210                 215                 220                 


Gly Leu His Leu Gly Ser Ala Ser Asn Phe Ser Phe Phe Arg Trp Met 
225                 230                 235                 240 


Arg Ser Leu Leu Leu Pro Ser Cys Arg Ser Leu Arg Ser Pro Gln Glu 
                245                 250                 255     


Gln Ile Ile Leu Ala Pro Ser Leu Ala Lys Val Asp Met Glu Met Thr 
            260                 265                 270         


Gln Leu Thr Gln Glu Asn Ala Asp Phe Ala Thr Arg Asp Arg Tyr His 
        275                 280                 285             


His Ser Ser Leu Val Asn Arg Glu Gln Leu Met Pro His Tyr 
    290                 295                 300         

<210>  1714
<211>  2711
<212>  DNA
<213>  Homo sapiens

<400>  1714
tctctctcgc ctgctgccat gcaagacgtg actttgcttc tccttcccct tctgccatga     60

tttgtgatgc ctcctcagcc atgtggaact gagtcatggc cggcttcaac atggggggcg    120

acctcaggga gcctgccgcc agcattcccc cgggctccct ggcagctgtt ggcatctcgt    180

ggtttctgta catcatcttc gtcttcctcc tgggcgccat ctgcactcga gaggcccttc    240

gctatgactt cctgatagcg gaaaaggtat ccctcatggg cttcctgttc cttttgggct    300

tatacatctc gtccctggct tcctgcatgg gaggacttta tggagctccc cgcatcctgc    360

agtgcattgc ccaggagaaa gtgatccctg cacttgcctg tctgggacaa gggaaggggc    420

caaacaaaac acccgtggct gccatctgcc tgaccagctt ggtgaccatg gcctttgttt    480

ttgtgggtca agtgaacgtt ctggccccca tcgtcaccat caacttcatg ctgacatacg    540

ttgcagtgga ctactcttac ttctccctgt ccatgtgttc ctgcagcctg accccggtgc    600

ctgagccggt gctcagggag ggcgcagaag gcctccactg ctctgagcac ctgctcttag    660

agaaagctcc cagttacggc tctgagggac ctgcccaaag agtcttggag ggcacgctac    720

tggaattcac caaggacatg gatcagctcc tccagctaac caggaagctt gagagtagcc    780

agcccaggca aggagagggt aacaggaccc cagaaagtca gaagaggaaa agcaagaagg    840

ccaccaagca gaccctacaa gatagcttcc tcttggacct caaatcccct ccttctttcc    900

ctgtcgagat ctctgacagg ttgcccgctg cctcctggga ggggcaggag tcctgctgga    960

acaagcagac ttccaagagc gaagggactc agcctgaggg aacatatgga gagcaacttg   1020

ttcctgagct gtgcaaccaa tcagagtcca gtggagaaga tttcttcctg aagtccaggc   1080

tccaagaaca agatgtctgg agaagatcca cttctttcta tacccacatg tgcaacccct   1140

gggtctccct gttgggggct gttgggtccc ttctcatcat gtttgtgata cagtgggtgt   1200

ataccctggt taacatgggt gttgctgcca tcgtgtattt ctacattggc cgggccagtc   1260

cagggcttca ccttggatca gcctccaact tcagcttttt ccggtggatg aggtctctct   1320

tgctcccctc ctgcaggagc ttgcggtccc ctcaggagca gatcatcttg gcgccgtccc   1380

tggctaaggt tgacatggag atgactcagc tcacccagga gaatgcagac ttcgccactc   1440

gggatcgcta ccaccactcc tccctcgtga accgggagca gctgatgcct cactactaga   1500

tgcagtgctg ggaccttcct cttttggagc tgtcccatgt acagtggacc caagctcagg   1560

accttcgtgg agctgcttct ccaacctgag aaactcaaga cccatcctcc cgctgtcact   1620

ttggacaatg gaaatctaca ttttcttttc cctttttttt tttttttgag acagagtctc   1680

gccctgtcac ccaggctgga gtccagtggc acaatcttgg ctcactgcaa cctctgcttc   1740

ccgagttcaa gcaattctcc tgcctcagcc tcctgagtag ctgggattat aggcatgcac   1800

caccacaccc agctattttt tgtattttta ctggagacag ggtttcacca tgttggccag   1860

gctggtctcg aactcctgac ctcgtgatcc acccgtctca gcctcccaaa gtactgggat   1920

tacaggcgtg agccaccatg cctggccaga aatctatgtt ttcttagaac atgtggaaga   1980

aggaaaaaga caaaaaagga aatctggatt ctgaggacca cgtctcaccc agggtgacat   2040

caggaatggt gctagcctct gcaacacgac acccagtctg aagagctcta tacaggtact   2100

aagactagca ggggacacca agactctgca caaccagatt gcttgtgcag agggccacaa   2160

taagtgtatg ttttatattt tattgtatta tttattcaaa aataaataat acactcacat   2220

gtttccacac ccaaaagata tatagagtga aaagtctccc tccaatcctt attctccacc   2280

tgctcagttc ctgtctaccc tggcctagag gtaaccacta ttctcatccg tacatccagc   2340

atttctttat ggatatacaa gcaaatggga atgtagagtc tcacattctc tctttataca   2400

caaaagttag cacgttatac acatgttctg caccttgctt ttttccctta acaatctatc   2460

ttggagacat ttcatatcaa ttcatatgcc atttgttcat ttttttcatt gtataaatgt   2520

gttataattt atttcgccag ttccacaatg atgagcattt ggattctttc caatcttttg   2580

caatgacaat cagctctgca gtgaataatc ttgtacaaat gtgcaagcat aaagtgtatc   2640

tctaggataa attcccaaaa gtggaattgc aggatcaaaa ggtacatgca tttgtaaact   2700

attattgttt a                                                        2711


<210>  1715
<211>  467
<212>  PRT
<213>  Homo sapiens

<400>  1715


Met Ala Gly Phe Asn Met Gly Gly Asp Leu Arg Glu Pro Ala Ala Ser 
1               5                   10                  15      


Ile Pro Pro Gly Ser Leu Ala Ala Val Gly Ile Ser Trp Phe Leu Tyr 
            20                  25                  30          


Ile Ile Phe Val Phe Leu Leu Gly Ala Ile Cys Thr Arg Glu Ala Leu 
        35                  40                  45              


Arg Tyr Asp Phe Leu Ile Ala Glu Lys Val Ser Leu Met Gly Phe Leu 
    50                  55                  60                  


Phe Leu Leu Gly Leu Tyr Ile Ser Ser Leu Ala Ser Cys Met Gly Gly 
65                  70                  75                  80  


Leu Tyr Gly Ala Pro Arg Ile Leu Gln Cys Ile Ala Gln Glu Lys Val 
                85                  90                  95      


Ile Pro Ala Leu Ala Cys Leu Gly Gln Gly Lys Gly Pro Asn Lys Thr 
            100                 105                 110         


Pro Val Ala Ala Ile Cys Leu Thr Ser Leu Val Thr Met Ala Phe Val 
        115                 120                 125             


Phe Val Gly Gln Val Asn Val Leu Ala Pro Ile Val Thr Ile Asn Phe 
    130                 135                 140                 


Met Leu Thr Tyr Val Ala Val Asp Tyr Ser Tyr Phe Ser Leu Ser Met 
145                 150                 155                 160 


Cys Ser Cys Ser Leu Thr Pro Val Pro Glu Pro Val Leu Arg Glu Gly 
                165                 170                 175     


Ala Glu Gly Leu His Cys Ser Glu His Leu Leu Leu Glu Lys Ala Pro 
            180                 185                 190         


Ser Tyr Gly Ser Glu Gly Pro Ala Gln Arg Val Leu Glu Gly Thr Leu 
        195                 200                 205             


Leu Glu Phe Thr Lys Asp Met Asp Gln Leu Leu Gln Leu Thr Arg Lys 
    210                 215                 220                 


Leu Glu Ser Ser Gln Pro Arg Gln Gly Glu Gly Asn Arg Thr Pro Glu 
225                 230                 235                 240 


Ser Gln Lys Arg Lys Ser Lys Lys Ala Thr Lys Gln Thr Leu Gln Asp 
                245                 250                 255     


Ser Phe Leu Leu Asp Leu Lys Ser Pro Pro Ser Phe Pro Val Glu Ile 
            260                 265                 270         


Ser Asp Arg Leu Pro Ala Ala Ser Trp Glu Gly Gln Glu Ser Cys Trp 
        275                 280                 285             


Asn Lys Gln Thr Ser Lys Ser Glu Gly Thr Gln Pro Glu Gly Thr Tyr 
    290                 295                 300                 


Gly Glu Gln Leu Val Pro Glu Leu Cys Asn Gln Ser Glu Ser Ser Gly 
305                 310                 315                 320 


Glu Asp Phe Phe Leu Lys Ser Arg Leu Gln Glu Gln Asp Val Trp Arg 
                325                 330                 335     


Arg Ser Thr Ser Phe Tyr Thr His Met Cys Asn Pro Trp Val Ser Leu 
            340                 345                 350         


Leu Gly Ala Val Gly Ser Leu Leu Ile Met Phe Val Ile Gln Trp Val 
        355                 360                 365             


Tyr Thr Leu Val Asn Met Gly Val Ala Ala Ile Val Tyr Phe Tyr Ile 
    370                 375                 380                 


Gly Arg Ala Ser Pro Gly Leu His Leu Gly Ser Ala Ser Asn Phe Ser 
385                 390                 395                 400 


Phe Phe Arg Trp Met Arg Ser Leu Leu Leu Pro Ser Cys Arg Ser Leu 
                405                 410                 415     


Arg Ser Pro Gln Glu Gln Ile Ile Leu Ala Pro Ser Leu Ala Lys Val 
            420                 425                 430         


Asp Met Glu Met Thr Gln Leu Thr Gln Glu Asn Ala Asp Phe Ala Thr 
        435                 440                 445             


Arg Asp Arg Tyr His His Ser Ser Leu Val Asn Arg Glu Gln Leu Met 
    450                 455                 460                 


Pro His Tyr 
465         

<210>  1716
<211>  1218
<212>  DNA
<213>  Homo sapiens

<400>  1716
tgcaatccat atgaaatgtg gtggtggatt cagctgaaac catggaatga atgggggcga     60

ggctggggat gtggaaactg tatcccaggg atcagatcta gacgactcag tggatgattg    120

catggggtgc aggtgggtgg gtgctggggg ggtagaaagg cacaggagca ggttctggca    180

ctggcgaatg aaaccgcttc tcacacaggt atccctcatg ggcttcctgt tccttttggg    240

cttatacatc tcgtccctgg cttcctgcat gggaggactt tatggagctc cccgcatcct    300

gcagtgcatt gcccaggaga aagtgatccc tgcacttgcc tgtctgggac aagggatctc    360

tgacaggttg cccgctgcct cctgggaggg gcaggagtcc tgctggaaca agcagattcg    420

ccactcggga tcgctaccac cactcctccc tcgtgaaccg ggagcagctg atgcctcact    480

actagatgca gtgctgggac cttcctcttt tggagctgtc ccatgtacag tggacccaag    540

ctcaggacct tcgtggagct gcttctccaa cctgagaaac tcaagaccca tcctcccgct    600

gtcactttgg acaatggaaa tctacatttt cttttccctt tttttttttt tttgagacag    660

agtctcgccc tgtcacccag gctggagtcc agtggcacaa tcttggctca ctgcaacctc    720

tgcttcccga gttcaagcaa ttctcctgcc tcagcctcct gagtagctgg gattataggc    780

atgcaccacc acacccagct attttttgta tttttactgg agacagggtt tcaccatgtt    840

ggccaggctg gtctcgaact cctgacctcg tgatccaccc gtctcagcct cccaaagtac    900

tgggattaca ggcgtgagcc accatgcctg gccagaaatc tatgttttct tagaacatgt    960

ggaagaagga aaaagacaaa aaaggaaatc tggattctga ggaccacgtc tcacccaggg   1020

tgacatcagg aatggtgcta gcctctgcaa cacgacaccc agtctgaaga gctctataca   1080

ggtactaaga ctagcagggg acaccaagac tctgcacaac cagattgctt gtgcagaggg   1140

ccacaataag tgtatgtttt atattttatt gtattattta ttcaaaaata aataatacac   1200

tcacatgttt ccacaccc                                                 1218


<210>  1717
<211>  202
<212>  PRT
<213>  Homo sapiens

<400>  1717


Met Asn Gly Gly Glu Ala Gly Asp Val Glu Thr Val Ser Gln Gly Ser 
1               5                   10                  15      


Asp Leu Asp Asp Ser Val Asp Asp Cys Met Gly Cys Arg Trp Val Gly 
            20                  25                  30          


Ala Gly Gly Val Glu Arg His Arg Ser Arg Phe Trp His Trp Arg Met 
        35                  40                  45              


Lys Pro Leu Leu Thr Gln Val Ser Leu Met Gly Phe Leu Phe Leu Leu 
    50                  55                  60                  


Gly Leu Tyr Ile Ser Ser Leu Ala Ser Cys Met Gly Gly Leu Tyr Gly 
65                  70                  75                  80  


Ala Pro Arg Ile Leu Gln Cys Ile Ala Gln Glu Lys Val Ile Pro Ala 
                85                  90                  95      


Leu Ala Cys Leu Gly Gln Gly Ile Ser Asp Arg Leu Pro Ala Ala Ser 
            100                 105                 110         


Trp Glu Gly Gln Glu Ser Cys Trp Asn Lys Gln Ile Arg His Ser Gly 
        115                 120                 125             


Ser Leu Pro Pro Leu Leu Pro Arg Glu Pro Gly Ala Ala Asp Ala Ser 
    130                 135                 140                 


Leu Leu Asp Ala Val Leu Gly Pro Ser Ser Phe Gly Ala Val Pro Cys 
145                 150                 155                 160 


Thr Val Asp Pro Ser Ser Gly Pro Ser Trp Ser Cys Phe Ser Asn Leu 
                165                 170                 175     


Arg Asn Ser Arg Pro Ile Leu Pro Leu Ser Leu Trp Thr Met Glu Ile 
            180                 185                 190         


Tyr Ile Phe Phe Ser Leu Phe Phe Phe Phe 
        195                 200         

<210>  1718
<211>  1724
<212>  DNA
<213>  Homo sapiens

<400>  1718
ctgccatgca agacgtgact ttgcttctcc ttccccttct gccatgattt gtgatgcctc     60

ctcagccatg tggaactgag tcatggccgg cttcaacatg gggggcgacc tcagggagcc    120

tgccgccagc attcccccgg gctccctggc agctgttggc atctcgtggt ttctgtacat    180

catcttcgtc ttcctcctgg gcgccatctg cactcgagag gcccttcgct atgacttcct    240

gatagcggaa aaggtatccc tcatgggctt cctgttcctt ttgggcttat acatctcgtc    300

cctggcttcc tgcatgggag gactttatgg agctccccgc atcctgcagt gcattgccca    360

ggagaaagtg atccctgcac ttgcctgtct gggacaaggg atctctgaca ggttgcccgc    420

tgcctcctgg gaggggcagg agtcctgctg gaacaagcag acttccaaga gcgaagggac    480

tcagcctgag ggaacatatg gagagcaact tgttcctgag ctgtgcaacc aatcagagtc    540

cagtggagaa gatttcttcc tgaagtccag gctccaagaa caagatgtct ggagaagatc    600

cacttctttc tatacccaca tgtgcaaccc ctgggtctcc ctgttggggg ctgttgggtc    660

ccttctcatc atgtttgtga tacagtgggt gtataccctg gttaacatgg gtgttgctgc    720

catcgtgtat ttctacattg gccgggccag tccagggctt caccttggat cagcctccaa    780

cttcagcttt ttccggtgga tgaggtctct cttgctcccc tcctgcagga gcttgcggtc    840

ccctcaggag cagatcatct tggcgccgtc cctggctaag gttgacatgg agatgactca    900

gctcacccag gagaatgcag acttcgccac tcgggatcgc taccaccact cctccctcgt    960

gaaccgggag cagctgatgc ctcactacta gatgcagtgc tgggaccttc ctcttttgga   1020

gctgtcccat gtacagtgga cccaagctca ggaccttcgt ggagctgctt ctccaacctg   1080

agaaactcaa gacccatcct cccgctgtca ctttggacaa tggaaatcta cattttcttt   1140

tccctttttt tttttttttg agacagagtc tcgccctgtc acccaggctg gagtccagtg   1200

gcacaatctt ggctcactgc aacctctgct tcccgagttc aagcaattct cctgcctcag   1260

cctcctgagt agctgggatt ataggcatgc accaccacac ccagctattt tttgtatttt   1320

tactggagac agggtttcac catgttggcc aggctggtct cgaactcctg acctcgtgat   1380

ccacccgtct cagcctccca aagtactggg attacaggcg tgagccacca tgcctggcca   1440

gaaatctatg ttttcttaga acatgtggaa gaaggaaaaa gacaaaaaag gaaatctgga   1500

ttctgaggac cacgtctcac ccagggtgac atcaggaatg gtgctagcct ctgcaacacg   1560

acacccagtc tgaagagctc tatacaggta ctaagactag caggggacac caagactctg   1620

cacaaccaga ttgcttgtgc agagggccac aataagtgta tgttttatat tttattgtat   1680

tatttattca aaaataaata atacactcac atgtttccac accc                    1724


<210>  1719
<211>  302
<212>  PRT
<213>  Homo sapiens

<400>  1719


Met Ala Gly Phe Asn Met Gly Gly Asp Leu Arg Glu Pro Ala Ala Ser 
1               5                   10                  15      


Ile Pro Pro Gly Ser Leu Ala Ala Val Gly Ile Ser Trp Phe Leu Tyr 
            20                  25                  30          


Ile Ile Phe Val Phe Leu Leu Gly Ala Ile Cys Thr Arg Glu Ala Leu 
        35                  40                  45              


Arg Tyr Asp Phe Leu Ile Ala Glu Lys Val Ser Leu Met Gly Phe Leu 
    50                  55                  60                  


Phe Leu Leu Gly Leu Tyr Ile Ser Ser Leu Ala Ser Cys Met Gly Gly 
65                  70                  75                  80  


Leu Tyr Gly Ala Pro Arg Ile Leu Gln Cys Ile Ala Gln Glu Lys Val 
                85                  90                  95      


Ile Pro Ala Leu Ala Cys Leu Gly Gln Gly Ile Ser Asp Arg Leu Pro 
            100                 105                 110         


Ala Ala Ser Trp Glu Gly Gln Glu Ser Cys Trp Asn Lys Gln Thr Ser 
        115                 120                 125             


Lys Ser Glu Gly Thr Gln Pro Glu Gly Thr Tyr Gly Glu Gln Leu Val 
    130                 135                 140                 


Pro Glu Leu Cys Asn Gln Ser Glu Ser Ser Gly Glu Asp Phe Phe Leu 
145                 150                 155                 160 


Lys Ser Arg Leu Gln Glu Gln Asp Val Trp Arg Arg Ser Thr Ser Phe 
                165                 170                 175     


Tyr Thr His Met Cys Asn Pro Trp Val Ser Leu Leu Gly Ala Val Gly 
            180                 185                 190         


Ser Leu Leu Ile Met Phe Val Ile Gln Trp Val Tyr Thr Leu Val Asn 
        195                 200                 205             


Met Gly Val Ala Ala Ile Val Tyr Phe Tyr Ile Gly Arg Ala Ser Pro 
    210                 215                 220                 


Gly Leu His Leu Gly Ser Ala Ser Asn Phe Ser Phe Phe Arg Trp Met 
225                 230                 235                 240 


Arg Ser Leu Leu Leu Pro Ser Cys Arg Ser Leu Arg Ser Pro Gln Glu 
                245                 250                 255     


Gln Ile Ile Leu Ala Pro Ser Leu Ala Lys Val Asp Met Glu Met Thr 
            260                 265                 270         


Gln Leu Thr Gln Glu Asn Ala Asp Phe Ala Thr Arg Asp Arg Tyr His 
        275                 280                 285             


His Ser Ser Leu Val Asn Arg Glu Gln Leu Met Pro His Tyr 
    290                 295                 300         

<210>  1720
<211>  1955
<212>  DNA
<213>  Homo sapiens

<400>  1720
tctctctcgc ctgctgccat gcaagacgtg actttgcttc tccttcccct tctgccatga     60

tttgtgatgc ctcctcagcc atgtggaact gagtcatggc cggcttcaac atggggggcg    120

acctcaggga gcctgccgcc agcattcccc cgggctccct ggcagctgtt ggcatctcgt    180

ggtttctgta catcatcttc gtcttcctcc tgggcgccat ctgcactcga gaggcccttc    240

gctatgactt cctgatagcg gaaaaggtat ccctcatggg cttcctgttc cttttgggct    300

tatacatctc gtccctggct tcctgcatgg gaggacttta tggagctccc cgcatcctgc    360

agtgcattgc ccaggagaaa gtgatccctg cacttgcctg tctgggacaa gggaaggggc    420

caaacaaaac acccgtggct gccatctgcc tgaccagctt ggtgaccatg gcctttgttt    480

ttgtgggtca agtgaacgtt ctggccccca tcgtcaccat caacttcatg ctgacatacg    540

ttgcagtgga ctactcttac ttctccctgt ccatgtgttc ctgcagcctg accccggtgc    600

ctgagccggt gctcagggag ggcgcagaag gcctccactg ctctgagcac ctgctcttag    660

agaaagctcc cagttacggc tctgagggac ctgcccaaag agtcttggag ggcacgctac    720

tggaattcac caaggacatg gatcagctcc tccagctaac caggaagctt gagagtagcc    780

agcccaggca aggagagggt aacaggaccc cagaaagtca gaagaggaaa agcaagaagg    840

ccaccaagca gaccctacaa gatagcttcc tcttggacct caaatcccct ccttctttcc    900

ctgtcgagat ctctgacagg ttgcccgctg cctcctggga ggggcaggag tcctgctgga    960

acaagcagac ttccaagagc gaagggactc agcctgaggg aacatatgga gagcaacttg   1020

ttcctgagct gtgcaaccaa tcagagtcca gtggagaagg agcttgcggt cccctcagga   1080

gcagatcatc ttggcgccgt ccctggctaa ggttgacatg gagatgactc agctcaccca   1140

ggagaatgca gacttcgcca ctcgggatcg ctaccaccac tcctccctcg tgaaccggga   1200

gcagctgatg cctcactact agatgcagtg ctgggacctt cctcttttgg agctgtccca   1260

tgtacagtgg acccaagctc aggaccttcg tggagctgct tctccaacct gagaaactca   1320

agacccatcc tcccgctgtc actttggaca atggaaatct acattttctt ttcccttttt   1380

tttttttttt gagacagagt ctcgccctgt cacccaggct ggagtccagt ggcacaatct   1440

tggctcactg caacctctgc ttcccgagtt caagcaattc tcctgcctca gcctcctgag   1500

tagctgggat tataggcatg caccaccaca cccagctatt ttttgtattt ttactggaga   1560

cagggtttca ccatgttggc caggctggtc tcgaactcct gacctcgtga tccacccgtc   1620

tcagcctccc aaagtactgg gattacaggc gtgagccacc atgcctggcc agaaatctat   1680

gttttcttag aacatgtgga agaaggaaaa agacaaaaaa ggaaatctgg attctgagga   1740

ccacgtctca cccagggtga catcaggaat ggtgctagcc tctgcaacac gacacccagt   1800

ctgaagagct ctatacaggt actaagacta gcaggggaca ccaagactct gcacaaccag   1860

attgcttgtg cagagggcca caataagtgt atgttttata ttttattgta ttatttattc   1920

aaaaataaat aatacactca catgtttcca caccc                              1955


<210>  1721
<211>  343
<212>  PRT
<213>  Homo sapiens

<400>  1721


Met Ala Gly Phe Asn Met Gly Gly Asp Leu Arg Glu Pro Ala Ala Ser 
1               5                   10                  15      


Ile Pro Pro Gly Ser Leu Ala Ala Val Gly Ile Ser Trp Phe Leu Tyr 
            20                  25                  30          


Ile Ile Phe Val Phe Leu Leu Gly Ala Ile Cys Thr Arg Glu Ala Leu 
        35                  40                  45              


Arg Tyr Asp Phe Leu Ile Ala Glu Lys Val Ser Leu Met Gly Phe Leu 
    50                  55                  60                  


Phe Leu Leu Gly Leu Tyr Ile Ser Ser Leu Ala Ser Cys Met Gly Gly 
65                  70                  75                  80  


Leu Tyr Gly Ala Pro Arg Ile Leu Gln Cys Ile Ala Gln Glu Lys Val 
                85                  90                  95      


Ile Pro Ala Leu Ala Cys Leu Gly Gln Gly Lys Gly Pro Asn Lys Thr 
            100                 105                 110         


Pro Val Ala Ala Ile Cys Leu Thr Ser Leu Val Thr Met Ala Phe Val 
        115                 120                 125             


Phe Val Gly Gln Val Asn Val Leu Ala Pro Ile Val Thr Ile Asn Phe 
    130                 135                 140                 


Met Leu Thr Tyr Val Ala Val Asp Tyr Ser Tyr Phe Ser Leu Ser Met 
145                 150                 155                 160 


Cys Ser Cys Ser Leu Thr Pro Val Pro Glu Pro Val Leu Arg Glu Gly 
                165                 170                 175     


Ala Glu Gly Leu His Cys Ser Glu His Leu Leu Leu Glu Lys Ala Pro 
            180                 185                 190         


Ser Tyr Gly Ser Glu Gly Pro Ala Gln Arg Val Leu Glu Gly Thr Leu 
        195                 200                 205             


Leu Glu Phe Thr Lys Asp Met Asp Gln Leu Leu Gln Leu Thr Arg Lys 
    210                 215                 220                 


Leu Glu Ser Ser Gln Pro Arg Gln Gly Glu Gly Asn Arg Thr Pro Glu 
225                 230                 235                 240 


Ser Gln Lys Arg Lys Ser Lys Lys Ala Thr Lys Gln Thr Leu Gln Asp 
                245                 250                 255     


Ser Phe Leu Leu Asp Leu Lys Ser Pro Pro Ser Phe Pro Val Glu Ile 
            260                 265                 270         


Ser Asp Arg Leu Pro Ala Ala Ser Trp Glu Gly Gln Glu Ser Cys Trp 
        275                 280                 285             


Asn Lys Gln Thr Ser Lys Ser Glu Gly Thr Gln Pro Glu Gly Thr Tyr 
    290                 295                 300                 


Gly Glu Gln Leu Val Pro Glu Leu Cys Asn Gln Ser Glu Ser Ser Gly 
305                 310                 315                 320 


Glu Gly Ala Cys Gly Pro Leu Arg Ser Arg Ser Ser Trp Arg Arg Pro 
                325                 330                 335     


Trp Leu Arg Leu Thr Trp Arg 
            340             

<210>  1722
<211>  2232
<212>  DNA
<213>  Homo sapiens

<400>  1722
tctctctcgc ctgctgccat gcaagacgtg actttgcttc tccttcccct tctgccatga     60

tttgtgatgc ctcctcagcc atgtggaact gagtcatggc cggcttcaac atggggggcg    120

acctcaggga gcctgccgcc agcattcccc cgggctccct ggcagctgtt ggcatctcgt    180

ggtttctgta catcatcttc gtcttcctcc tgggcgccat ctgcactcga gaggcccttc    240

gctatgactt cctgatagcg gaaaaggtat ccctcatggg cttcctgttc cttttgggct    300

tatacatctc gtccctggct tcctgcatgg gaggacttta tggagctccc cgcatcctgc    360

agtgcattgc ccaggagaaa gtgatccctg cacttgcctg tctgggacaa gggaaggggc    420

caaacaaaac acccgtggct gccatctgcc tgaccagctt ggtgaccatg gcctttgttt    480

ttgtgggtca agtgaacgtt ctggccccca tcgtcaccat caacttcatg ctgacatacg    540

ttgcagtgga ctactcttac ttctccctgt ccatgtgttc ctgcagcctg accccggtgc    600

ctgagccggt gctcagggag ggcgcagaag gcctccactg ctctgagcac ctgctcttag    660

agaaagctcc cagttacggc tctgagggac ctgcccaaag agtcttggag ggcacgctac    720

tggaattcac caaggacatg gatcagctcc tccagctaac caggaagctt gagagtagcc    780

agcccaggca aggagagggt aacaggaccc cagaaagtca gaagaggaaa agcaagaagg    840

ccaccaagca gaccctacaa gatagcttcc tcttggacct caaatcccct ccttctttcc    900

ctgtcgagat ctctgacagg ttgcccgctg cctcctggga ggggcaggag tcctgctgga    960

acaagcagac ttccaagagc gaagggactc agcctgaggg aacatatgga gagcaacttg   1020

ttcctgagct gtgcaaccaa tcagagtcca gtggagaaga tttcttcctg aagtccaggc   1080

tccaagaaca agatgtctgg agaagatcca cttctttcta tacccacatg tgcaacccct   1140

gggtctccct gttgggggct gttgggtccc ttctcatcat gtttgtgata cagtgggtgt   1200

ataccctggt taacatgggt gttgctgcca tcgtgtattt ctacattggc cgggccagtc   1260

cagggcttca ccttggatca gcctccaact tcagcttttt ccggtggatg aggtctctct   1320

tgctcccctc ctgcaggagc ttgcggtccc ctcaggagca gatcatcttg gcgccgtccc   1380

tggctaaggt tgacatggag atgactcagc tcacccagga gaatgcagac ttcgccactc   1440

gggatcgcta ccaccactcc tccctcgtga accgggagca gctgatgcct cactactaga   1500

tgcagtgctg ggaccttcct cttttggagc tgtcccatgt acagtggacc caagctcagg   1560

accttcgtgg agctgcttct ccaacctgag aaactcaaga cccatcctcc cgctgtcact   1620

ttggacaatg gaaatctaca ttttcttttc cctttttttt tttttttgag acagagtctc   1680

gccctgtcac ccaggctgga gtccagtggc acaatcttgg ctcactgcaa cctctgcttc   1740

ccgagttcaa gcaattctcc tgcctcagcc tcctgagtag ctgggattat aggcatgcac   1800

caccacaccc agctattttt tgtattttta ctggagacag ggtttcacca tgttggccag   1860

gctggtctcg aactcctgac ctcgtgatcc acccgtctca gcctcccaaa gtactgggat   1920

tacaggcgtg agccaccatg cctggccaga aatctatgtt ttcttagaac atgtggaaga   1980

aggaaaaaga caaaaaagga aatctggatt ctgaggacca cgtctcaccc agggtgacat   2040

caggaatggt gctagcctct gcaacacgac acccagtctg aagagctcta tacaggtact   2100

aagactagca ggggacacca agactctgca caaccagatt gcttgtgcag agggccacaa   2160

taagtgtatg ttttatattt tattgtatta tttattcaaa aataaataat acactcacat   2220

gtttccacac cc                                                       2232


<210>  1723
<211>  467
<212>  PRT
<213>  Homo sapiens

<400>  1723


Met Ala Gly Phe Asn Met Gly Gly Asp Leu Arg Glu Pro Ala Ala Ser 
1               5                   10                  15      


Ile Pro Pro Gly Ser Leu Ala Ala Val Gly Ile Ser Trp Phe Leu Tyr 
            20                  25                  30          


Ile Ile Phe Val Phe Leu Leu Gly Ala Ile Cys Thr Arg Glu Ala Leu 
        35                  40                  45              


Arg Tyr Asp Phe Leu Ile Ala Glu Lys Val Ser Leu Met Gly Phe Leu 
    50                  55                  60                  


Phe Leu Leu Gly Leu Tyr Ile Ser Ser Leu Ala Ser Cys Met Gly Gly 
65                  70                  75                  80  


Leu Tyr Gly Ala Pro Arg Ile Leu Gln Cys Ile Ala Gln Glu Lys Val 
                85                  90                  95      


Ile Pro Ala Leu Ala Cys Leu Gly Gln Gly Lys Gly Pro Asn Lys Thr 
            100                 105                 110         


Pro Val Ala Ala Ile Cys Leu Thr Ser Leu Val Thr Met Ala Phe Val 
        115                 120                 125             


Phe Val Gly Gln Val Asn Val Leu Ala Pro Ile Val Thr Ile Asn Phe 
    130                 135                 140                 


Met Leu Thr Tyr Val Ala Val Asp Tyr Ser Tyr Phe Ser Leu Ser Met 
145                 150                 155                 160 


Cys Ser Cys Ser Leu Thr Pro Val Pro Glu Pro Val Leu Arg Glu Gly 
                165                 170                 175     


Ala Glu Gly Leu His Cys Ser Glu His Leu Leu Leu Glu Lys Ala Pro 
            180                 185                 190         


Ser Tyr Gly Ser Glu Gly Pro Ala Gln Arg Val Leu Glu Gly Thr Leu 
        195                 200                 205             


Leu Glu Phe Thr Lys Asp Met Asp Gln Leu Leu Gln Leu Thr Arg Lys 
    210                 215                 220                 


Leu Glu Ser Ser Gln Pro Arg Gln Gly Glu Gly Asn Arg Thr Pro Glu 
225                 230                 235                 240 


Ser Gln Lys Arg Lys Ser Lys Lys Ala Thr Lys Gln Thr Leu Gln Asp 
                245                 250                 255     


Ser Phe Leu Leu Asp Leu Lys Ser Pro Pro Ser Phe Pro Val Glu Ile 
            260                 265                 270         


Ser Asp Arg Leu Pro Ala Ala Ser Trp Glu Gly Gln Glu Ser Cys Trp 
        275                 280                 285             


Asn Lys Gln Thr Ser Lys Ser Glu Gly Thr Gln Pro Glu Gly Thr Tyr 
    290                 295                 300                 


Gly Glu Gln Leu Val Pro Glu Leu Cys Asn Gln Ser Glu Ser Ser Gly 
305                 310                 315                 320 


Glu Asp Phe Phe Leu Lys Ser Arg Leu Gln Glu Gln Asp Val Trp Arg 
                325                 330                 335     


Arg Ser Thr Ser Phe Tyr Thr His Met Cys Asn Pro Trp Val Ser Leu 
            340                 345                 350         


Leu Gly Ala Val Gly Ser Leu Leu Ile Met Phe Val Ile Gln Trp Val 
        355                 360                 365             


Tyr Thr Leu Val Asn Met Gly Val Ala Ala Ile Val Tyr Phe Tyr Ile 
    370                 375                 380                 


Gly Arg Ala Ser Pro Gly Leu His Leu Gly Ser Ala Ser Asn Phe Ser 
385                 390                 395                 400 


Phe Phe Arg Trp Met Arg Ser Leu Leu Leu Pro Ser Cys Arg Ser Leu 
                405                 410                 415     


Arg Ser Pro Gln Glu Gln Ile Ile Leu Ala Pro Ser Leu Ala Lys Val 
            420                 425                 430         


Asp Met Glu Met Thr Gln Leu Thr Gln Glu Asn Ala Asp Phe Ala Thr 
        435                 440                 445             


Arg Asp Arg Tyr His His Ser Ser Leu Val Asn Arg Glu Gln Leu Met 
    450                 455                 460                 


Pro His Tyr 
465         

<210>  1724
<211>  2323
<212>  DNA
<213>  Homo sapiens

<400>  1724
aattagcctc ctcaatgaaa aagaaagagg gggaggaaga ggaagagaaa agaagaagaa     60

aaccctgaac atggtttcat tggatattca cccgaactgc tacagaacaa cacgctgccc    120

gattacagcc cgggggaatc ttttttcact gtctttgggg ttttcttccc agcggctaca    180

ggagtcatgg ccggcttcaa catggggggc gacctcaggg agcctgccgc cagcattccc    240

ccgggctccc tggcagctgt tggcatctcg tggtttctgt acatcatctt cgtcttcctc    300

ctgggcgcca tctgcactcg agaggccctt cgctatgact tcctgatagc ggaaaaggta    360

tccctcatgg gcttcctgtt ccttttgggc ttatacatct cgtccctggc ttcctgcatg    420

ggaggacttt atggagctcc ccgcatcctg cagtgcattg cccaggagaa agtgatccct    480

gcacttgcct gtctgggaca agggaagggg ccaaacaaaa cacccgtggc tgccatctgc    540

ctgaccagct tggtgaccat ggcctttgtt tttgtgggtc aagtgaacgt tctggccccc    600

atcgtcacca tcaacttcat gctgacatac gttgcagtgg actactctta cttctccctg    660

tccatgtgtt cctgcagcct gaccccggtg cctgagccgg tgctcaggga gggcgcagaa    720

ggcctccact gctctgagca cctgctctta gagaaagctc ccagttacgg ctctgaggga    780

cctgcccaaa gagtcttgga gggcacgcta ctggaattca ccaaggacat ggatcagctc    840

ctccagctaa ccaggaagct tgagagtagc cagcccaggc aaggagaggg taacaggacc    900

ccagaaagtc agaagaggaa aagcaagaag gccaccaagc agaccctaca agatagcttc    960

ctcttggacc tcaaatcccc tccttctttc cctgtcgaga tctctgacag gttgcccgct   1020

gcctcctggg aggggcagga gtcctgctgg aacaagcaga cttccaagag cgaagggact   1080

cagcctgagg gaacatatgg agagcaactt gttcctgagc tgtgcaacca atcagagtcc   1140

agtggagaag atttcttcct gaagtccagg ctccaagaac aagatgtctg gagaagatcc   1200

acttctttct atacccacat gtgcaacccc tgggtctccc tgttgggggc tgttgggtcc   1260

cttctcatca tgtttgtgat acagtgggtg tataccctgg ttaacatggg tgttgctgcc   1320

atcgtgtatt tctacattgg ccgggccagt ccagggcttc accttggatc agcctccaac   1380

ttcagctttt tccggtggat gaggtctctc ttgctcccct cctgcaggag cttgcggtcc   1440

cctcaggagc agatcatctt ggcgccgtcc ctggctaagg ttgacatgga gatgactcag   1500

ctcacccagg agaatgcaga cttcgccact cgggatcgct accaccactc ctccctcgtg   1560

aaccgggagc agctgatgcc tcactactag atgcagtgct gggaccttcc tcttttggag   1620

ctgtcccatg tacagtggac ccaagctcag gaccttcgtg gagctgcttc tccaacctga   1680

gaaactcaag acccatcctc ccgctgtcac tttggacaat ggaaatctac attttctttt   1740

cccttttttt ttttttttga gacagagtct cgccctgtca cccaggctgg agtccagtgg   1800

cacaatcttg gctcactgca acctctgctt cccgagttca agcaattctc ctgcctcagc   1860

ctcctgagta gctgggatta taggcatgca ccaccacacc cagctatttt ttgtattttt   1920

actggagaca gggtttcacc atgttggcca ggctggtctc gaactcctga cctcgtgatc   1980

cacccgtctc agcctcccaa agtactggga ttacaggcgt gagccaccat gcctggccag   2040

aaatctatgt tttcttagaa catgtggaag aaggaaaaag acaaaaaagg aaatctggat   2100

tctgaggacc acgtctcacc cagggtgaca tcaggaatgg tgctagcctc tgcaacacga   2160

cacccagtct gaagagctct atacaggtac taagactagc aggggacacc aagactctgc   2220

acaaccagat tgcttgtgca gagggccaca ataagtgtat gttttatatt ttattgtatt   2280

atttattcaa aaataaataa tacactcaca tgtttccaca ccc                     2323


<210>  1725
<211>  467
<212>  PRT
<213>  Homo sapiens

<400>  1725


Met Ala Gly Phe Asn Met Gly Gly Asp Leu Arg Glu Pro Ala Ala Ser 
1               5                   10                  15      


Ile Pro Pro Gly Ser Leu Ala Ala Val Gly Ile Ser Trp Phe Leu Tyr 
            20                  25                  30          


Ile Ile Phe Val Phe Leu Leu Gly Ala Ile Cys Thr Arg Glu Ala Leu 
        35                  40                  45              


Arg Tyr Asp Phe Leu Ile Ala Glu Lys Val Ser Leu Met Gly Phe Leu 
    50                  55                  60                  


Phe Leu Leu Gly Leu Tyr Ile Ser Ser Leu Ala Ser Cys Met Gly Gly 
65                  70                  75                  80  


Leu Tyr Gly Ala Pro Arg Ile Leu Gln Cys Ile Ala Gln Glu Lys Val 
                85                  90                  95      


Ile Pro Ala Leu Ala Cys Leu Gly Gln Gly Lys Gly Pro Asn Lys Thr 
            100                 105                 110         


Pro Val Ala Ala Ile Cys Leu Thr Ser Leu Val Thr Met Ala Phe Val 
        115                 120                 125             


Phe Val Gly Gln Val Asn Val Leu Ala Pro Ile Val Thr Ile Asn Phe 
    130                 135                 140                 


Met Leu Thr Tyr Val Ala Val Asp Tyr Ser Tyr Phe Ser Leu Ser Met 
145                 150                 155                 160 


Cys Ser Cys Ser Leu Thr Pro Val Pro Glu Pro Val Leu Arg Glu Gly 
                165                 170                 175     


Ala Glu Gly Leu His Cys Ser Glu His Leu Leu Leu Glu Lys Ala Pro 
            180                 185                 190         


Ser Tyr Gly Ser Glu Gly Pro Ala Gln Arg Val Leu Glu Gly Thr Leu 
        195                 200                 205             


Leu Glu Phe Thr Lys Asp Met Asp Gln Leu Leu Gln Leu Thr Arg Lys 
    210                 215                 220                 


Leu Glu Ser Ser Gln Pro Arg Gln Gly Glu Gly Asn Arg Thr Pro Glu 
225                 230                 235                 240 


Ser Gln Lys Arg Lys Ser Lys Lys Ala Thr Lys Gln Thr Leu Gln Asp 
                245                 250                 255     


Ser Phe Leu Leu Asp Leu Lys Ser Pro Pro Ser Phe Pro Val Glu Ile 
            260                 265                 270         


Ser Asp Arg Leu Pro Ala Ala Ser Trp Glu Gly Gln Glu Ser Cys Trp 
        275                 280                 285             


Asn Lys Gln Thr Ser Lys Ser Glu Gly Thr Gln Pro Glu Gly Thr Tyr 
    290                 295                 300                 


Gly Glu Gln Leu Val Pro Glu Leu Cys Asn Gln Ser Glu Ser Ser Gly 
305                 310                 315                 320 


Glu Asp Phe Phe Leu Lys Ser Arg Leu Gln Glu Gln Asp Val Trp Arg 
                325                 330                 335     


Arg Ser Thr Ser Phe Tyr Thr His Met Cys Asn Pro Trp Val Ser Leu 
            340                 345                 350         


Leu Gly Ala Val Gly Ser Leu Leu Ile Met Phe Val Ile Gln Trp Val 
        355                 360                 365             


Tyr Thr Leu Val Asn Met Gly Val Ala Ala Ile Val Tyr Phe Tyr Ile 
    370                 375                 380                 


Gly Arg Ala Ser Pro Gly Leu His Leu Gly Ser Ala Ser Asn Phe Ser 
385                 390                 395                 400 


Phe Phe Arg Trp Met Arg Ser Leu Leu Leu Pro Ser Cys Arg Ser Leu 
                405                 410                 415     


Arg Ser Pro Gln Glu Gln Ile Ile Leu Ala Pro Ser Leu Ala Lys Val 
            420                 425                 430         


Asp Met Glu Met Thr Gln Leu Thr Gln Glu Asn Ala Asp Phe Ala Thr 
        435                 440                 445             


Arg Asp Arg Tyr His His Ser Ser Leu Val Asn Arg Glu Gln Leu Met 
    450                 455                 460                 


Pro His Tyr 
465         

<210>  1726
<211>  784
<212>  DNA
<213>  Homo sapiens

<400>  1726
aagcagactt ccaagagcga agggactcag cctgagggaa catatggaga gcaacttgtt     60

cctgagctgt gcaaccaatc agagtccagt ggagaagatt tcttcctgaa gtccaggctc    120

caagaacaag atgtctggag aagatccact tctttctata cccacatgtg caacccctgg    180

gtctccctgt tgggggctgt tgggtccctt ctcatcatgt ttgtgataca gtgggtgtat    240

accctggtta acatgggtgt tgctgccatc gtgtatttct acattggccg ggccagtcca    300

gggcttcacc ttggtctgtg ccaatttgga gccagtacca gaatggatga gtgtccagag    360

tcctgggagg tgccaagggt gtcccattcc tggctgggct tgggcctgga ttgtggcatg    420

ggaacctaac aactgggcac ctccgggaga ctcagatgtt gctcctgcgt gcactccacc    480

acactcggcc cccagattcg gctcatcaga agcttcctct aggctcatgt cctcttccct    540

tcttatcctc agtcatcaag aacagaggct ttatttagaa tctggttgct ggggtgataa    600

gtcactactc tcagtgagtt tacagtctaa gacacattca catcaatgca taatcacaca    660

caagattaaa gcccaaggga aatgtaacgc caggaagcac attcttccat ctgagtcaga    720

ggtagttgac atgactgggt tggggacagt gcagaggcca agtatagaaa taaagtggag    780

atcc                                                                 784


<210>  1727
<211>  87
<212>  PRT
<213>  Homo sapiens

<400>  1727


Met Cys Asn Pro Trp Val Ser Leu Leu Gly Ala Val Gly Ser Leu Leu 
1               5                   10                  15      


Ile Met Phe Val Ile Gln Trp Val Tyr Thr Leu Val Asn Met Gly Val 
            20                  25                  30          


Ala Ala Ile Val Tyr Phe Tyr Ile Gly Arg Ala Ser Pro Gly Leu His 
        35                  40                  45              


Leu Gly Leu Cys Gln Phe Gly Ala Ser Thr Arg Met Asp Glu Cys Pro 
    50                  55                  60                  


Glu Ser Trp Glu Val Pro Arg Val Ser His Ser Trp Leu Gly Leu Gly 
65                  70                  75                  80  


Leu Asp Cys Gly Met Gly Thr 
                85          

<210>  1728
<211>  493
<212>  DNA
<213>  Homo sapiens

<400>  1728
cagggtaaag ggtttcctga agtttctacc tgctctaagt ttctaccctt gaggctgatt     60

gactagtcca gtgagatcaa ggaaatgaaa ggcatttcac acaccagcag gatgccctgg    120

cccagcccca gccctggtgg aagacccagc tgttcatgtg ggagcctgtg ctgtttggga    180

cctgggatgg tgtgttcaca tcctgcatga tcaacatctt tggggttgtg ctcttcctga    240

ggactggctg gctggtggga aacacaggag tgctcctggg catgttcctg gtgtccttcg    300

tcatcctggt ggccctcgtc acggtgctgt ctggcattgg cgtcggggag cgcagcagca    360

tcggcagcgg tggcgtctac tccatgatct cctcggtcct gggtgggcag acgggaggca    420

ccatcgggct gctctatgtg tttggacagt gtgttgcagg tgccatgtat atcaccggct    480

ttgctgaatc cat                                                       493


<210>  1729
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  1729


Met Trp Glu Pro Val Leu Phe Gly Thr Trp Asp Gly Val Phe Thr Ser 
1               5                   10                  15      


Cys Met Ile Asn Ile Phe Gly Val Val Leu Phe Leu Arg Thr Gly Trp 
            20                  25                  30          


Leu Val Gly Asn Thr Gly Val Leu Leu Gly Met Phe Leu Val Ser Phe 
        35                  40                  45              


Val Ile Leu Val Ala Leu Val Thr Val Leu Ser Gly Ile Gly Val Gly 
    50                  55                  60                  


Glu Arg Ser Ser Ile Gly Ser Gly Gly Val Tyr Ser Met Ile Ser Ser 
65                  70                  75                  80  


Val Leu Gly Gly Gln Thr Gly Gly Thr Ile Gly Leu Leu Tyr Val Phe 
                85                  90                  95      


Gly Gln Cys Val Ala Gly Ala Met Tyr Ile Thr Gly Phe Ala Glu 
            100                 105                 110     

<210>  1730
<211>  9467
<212>  DNA
<213>  Homo sapiens

<400>  1730
agaaaggcgc aggggtggga gctgttgccg aagctgccac agcaaaagtt ctcccccctc     60

cccccttccc ctcctctcaa ggcccctaga aaggttggag ctgccgccgc ctgcagtcgg    120

tgaccgcgcg actcggcgcc cgcccgcgga tagagggagg aatcagcagc ttggaaattc    180

aagcacgtga tctggcggga tgggcgtttg cctaacgtat ttaatggagg aatcggatgg    240

cataagtgat taaggtggta ttgaggattt ctgaagccta tgaaaggcag ttatacttaa    300

gcatgaacat tgacgacaaa ctggaaggat tgtttcttaa atgtggcggc atagacgaaa    360

tgcagtcttc caggacaatg gttgtaatgg gtggagtgtc tggccagtct actgtgtctg    420

gagagctaca ggattcagta cttcaagatc gaagtatgcc tcaccaggag atccttgctg    480

cagatgaagt gttacaagaa agtgaaatga gacaacagga tatgatatca catgatgaac    540

tcatggtcca tgaggagaca gtgaaaaatg atgaagagca gatggaaaca catgaaagac    600

ttcctcaagg actacagtat gcacttaatg tccctataag cgtaaagcag gaaattactt    660

ttactgatgt atctgagcaa ctgatgagag acaaaaaaca aatcagagag ccagtagact    720

tacagaaaaa gaagaagcgg aaacaacgtt ctcccgcaaa aatccttaca ataaatgagg    780

atggatcact tggtttgaaa acccctaaat ctcacgtttg tgagcactgc aatgctgcct    840

ttagaacgaa ctatcactta cagagacatg tcttcattca tacaggtgaa aaaccatttc    900

aatgtagtca atgtgacatg cgtttcatac agaagtacct gcttcagaga catgagaaga    960

ttcatactgg tgaaaaacca tttcgctgtg atgaatgtgg tatgagattc atacaaaaat   1020

atcatatgga aaggcataag agaactcata gtggagaaaa accttaccag tgtgaatact   1080

gtttacagta tttttccaga acagatcgtg tattgaaaca taaacgtatg tgccatgaaa   1140

atcatgacaa aaaactaaat agatgtgcca tcaaaggtgg ccttctgaca tctgaggaag   1200

attctggctt ttctacatca ccaaaagaca actcactgcc aaaaaagaaa aggcagaaaa   1260

cggagaaaaa atcatctgga atggacaaag agagtgcttt ggacaaatct gacctgaaaa   1320

aagacaaaaa tgattacttg cctctttatt cttcaagtac taaagtaaaa gatgagtata   1380

tggttgcaga atatgctgtt gaaatgccac attcgtcagt tgggggctcg catttagaag   1440

atgcgtcagg agaaatacac ccacctaagt tagttctcaa aaaaattaat agtaagagaa   1500

gtctgaaaca gccactggag caaaatcaaa caatttcacc tttatccaca tatgaagaga   1560

gcaaagtttc aaagtatgct tttgaacttg tggataaaca ggctttactg gactcagaag   1620

gcaatgctga cattgatcag gttgataatt tgcaggaggg gcccagtaaa cctgtgcata   1680

gtagtactaa ttatgatgat gccatgcagt ttttgaagaa gaagcggtat cttcaagcag   1740

caagtaacaa cagcagggaa tatgcgctga atgtgggtac catagcttct cagccttctg   1800

taacacaagc agctgtggca agtgtcattg atgaaagtac cacggcatcc atattagagt   1860

cacaggcact gaatgtggag attaagagta atcatgacaa aaatgttatt ccagatgagg   1920

tactgcagac tctgttggat cattattccc acaaagctaa tggacagcat gagatatcct   1980

tcagtgttgc agatactgaa gtgacttcta gcatatcaat aaattcttca gaagtaccag   2040

aggtcacccc gtcagagaat gttggatcaa gctcccaagc atcctcatca gataaagcca   2100

acatgttgca ggaatactcc aagtttctgc agcaggcttt ggacagaact agccaaaatg   2160

atgcctattt gaatagcccg agccttaact ttgtgactga taaccagacc ctcccaaatc   2220

agccagcatt ctcttccata gacaagcagg tctatgccac catgcccatc aatagctttc   2280

gatcaggaat gaattctcca ctaagaacaa ctccagataa gtcccacttt ggactaatag   2340

ttggtgattc acagcactca tttccctttt caggtgatga gacaaaccat gcttctgcca   2400

catcaacaca ggactttctg gatcaagtga cttctcagaa gaaagctgag gcccagcctg   2460

tccaccaagc ttaccaaatg agctcctttg aacagccctt ccgtgctccc tatcatggat   2520

caagagctgg aatagctact caatttagca ctgccaatgg acaggtgaac cttcggggac   2580

cagggacaag tgctgaattt tcagaatttc ccttggtgaa tgtaaatgat aatagagctg   2640

ggatgacatc ttcacctgat gccacaactg gccagacttt tggctaaaaa aaaaaaaaaa   2700

gtgtaaataa tactggcact ttagaacaga ttaatcaaga gtggggttac tctgtgtaaa   2760

tggagtgctg tacagattta agagcaatgc gtaataacaa gttaagctga tatgaatagc   2820

aagataatcc aataactgca tttcgtttgg ttagtcagca ttctttgaac tgccttacat   2880

gttgtcacct ttatagaagc aatgcattac ttgttttaga tcagaaactt gctattccac   2940

ccacaccaag ttaaaaagga aaaaaaaaag actttcgcac aattgtttcc taactgataa   3000

cattgtacat tcttaggaga ttagtaattg tgtgaaattt actcatactg tttctaagtt   3060

tttcagcata gtcattgcac ttcagcaggg aatctgagta tactttacag acagagtgaa   3120

cttaaaagtt taatgtcaag agattatggc ttaaataaat tagtgtgtcc tataggggga   3180

aaaaaaccaa gaaaccacct tttaaaaaga atgatatgcc atataccctt gattttcatt   3240

ttgcattata ttgacgtgtt tttttgaagg aaaaaaagta ataaaaatct gatagtctaa   3300

gactccacta tttaaaagcc taattacttt aaaaatatgc atactttcag aacttttacc   3360

aaaacacaca actgttgaag cagtcacttc tctatggaag tatgcatatt ggtgtcagtt   3420

tctttgtaca gttgtactta gatatttttt atgatttttc atgtgcaggt atcaaggttt   3480

tgaagtttta gtaaaagaaa ttctgtagat tacattccca agaacataat gcttacacaa   3540

aatgtatatt ccacgtttta aagcttaatt gtattttact ttacatatac acttcagtta   3600

acatagagca cttagaatct atttggtatt tttgatttct caaagtaaaa aaaaaattag   3660

atttttaggt ttgatatggt tgtgtcataa tcatctcgta attgacaatt ttaacttttg   3720

gcaataaaag gaaattggga tatctttgga actgtaaaac ctggtttaat ctttttcttt   3780

ctagactctt gatagattgg ataattaaac agtatccaga gaaactaaag aaatgggcat   3840

tttaattgca tattttatct tgagttactt tttaatgaac actgctcatt acaactttac   3900

aaaccaaaag tgtttactaa ttccagtaac taccatttct ttttcagcta gatgagtgat   3960

cggaaaattt ttgttgcatt tcaaaatcta aataaactac agactttatc cttataccat   4020

gaatgttttt ttttaatact ctgtcttaaa ataatacagc atggtacaat aaatagtgct   4080

tttatgtata tatacacaca cacacttttc tgaagaatga tggtttgagt tatgcgttgg   4140

gcagttttga tttttggaag ttatattagt tattgactct ttgttacaac tttttcattt   4200

ttacatttta aattttctgc catcgttgtc acaatgcaca tcctgatata gcaccagtga   4260

aaatctaaaa ttaataccct tggaaaatga aaatattctt aatttccatt ttgactctta   4320

tactggccct atagctctgc agtctttgtt tcaatataga atatgttatc catttaaatt   4380

attttttctt ttatttaatg ttatcccaag actgttctca taaagaaagg gaagaaataa   4440

ctatccaccc ttaacatcct tcatttattt tgaatatatt ggtgttttta tgataaggaa   4500

tataaattat atttaatgtg gtttcctgta tactttggtt attaagtttt gcttgaaata   4560

gtagttttcc cgtttgacag ctttctttgc tgccaaagtt ttcaagaatt taagacttct   4620

ttgaagtaaa tatttaagtt ctgccattat tgactcttaa gattgtgtgt gttgtgttgt   4680

gcattacata attacaaaaa ggcttcattc aggtgatacg ttaaaaatgg aactgtgctc   4740

accctaaata ggcattggta tttttctctt ttggtgagag taggcattta tttcttgagt   4800

tgttttggag cctgatcaaa aattttgttc atggagaact tgatgcaatt ttgatacagt   4860

ggagaggttt ttttcggttg ttttaacatc accagcatag tttttagaat gtgactcttg   4920

ctgagcattt agggtgagct tgggaaggaa ggcctttgaa aatggtagtt atgcaagcag   4980

actttcaggt gttgcattcc tgttttcaac acatttcttt aaatctacat aatggcagac   5040

ttttctacca ggttataagc agtttttaga taagtgatac tcagccagca taacttattg   5100

acttaccatt tacgtatagt catcactctc ttactgtgaa attccaaatg cctaccagag   5160

ttaccttgtt ctatcataat atgacaaaca tctcaacagt tttggatttc cccactttgg   5220

ttcagaaggt tatttaattt ctatctgggc attaatggag aaaataagta gccttgtgtg   5280

ctgcttcaga ttgaaacatg gaggatatga gatattcttc tgcaattcat gtttctcatt   5340

tctcaaagtg agcacattgt tctataaaaa catgctggta cacccttaaa cttttgatca   5400

atctgagtga ggtgtgcttt tcctcttggg acctactcac gtttgaagat tggaaacatc   5460

acgttaggcg aggcagtatc tcttgaacat cttctaaagg gttttttaaa accttattct   5520

cacatatttc atttgtcttg aatatttaag tggctcttaa acgttttggg tctacatgca   5580

aatgtggtac ttaacaaggt aggaatccat cttcttagct ctggctgagg gtgccagcca   5640

tcggtcaggt catttttatc tcaagaggca gaaggcagtt atgtcaagaa ttgtgctcag   5700

ggcaggattt cgtttccaca gaggagagac acttgcagag tgccagctag gttagatctt   5760

ttgccgcttc tttcatttga ttaatttggg tttttaaagg gctgtttaaa aaaaaaaaaa   5820

aaaggccggg aaactttaaa agtaggcatt actgtagtac tgcatttctt agaacatttt   5880

aaactagaac tcattttttt ttcacagtat atttacttga agaagcacta taataatcat   5940

tgagaagtat tttgagtctg aaatttaatt taattttccg tttcaaattg ctttatttca   6000

gggaaataat tttccagttg ttttgctata ttctgcaaat aaaaaccgtg tttccttttt   6060

tcacttaaac tttggtagga aacaaactaa agcagacaaa catttcttgt tatgtttgtt   6120

gctttcttta atccaatgga taaaaaagta aaaccctgta aacattattt tattttttta   6180

tgcaatacca tgctgtaaat atggttcatc aaataaggat gtacctatga ttgaatcttt   6240

aattctgcac agttagagtt tatatataaa cgtgtcttga caatcaagga cttttatgtg   6300

agtcttcctt tatgatgttt attaatgtta tgcattccat ttgttttgaa gtgagtacca   6360

atgtgctaat ttgtattgtc tgaaagtatg taatgttttt acagcttgtt tttaagaatc   6420

tgtaaatatg tacaaacaaa tcacagtact gctttatgtt agaaggcata tgatgttgta   6480

ctgtatgtaa gcaataatac atagcagtgc taactttaca agtagcatca ggaaagttct   6540

aaaaacattt cagagttatt aattatcctt atttcattta ataatgatta tctttaatca   6600

gtttttataa gcaaattcca ttgttcctcc tattggaacg taacactgtt tacacagcat   6660

aattgaagtt gcaggggaga caggctaaat ctgacttcat ctgtactcac tttcactaag   6720

cattgaatgg ccttaccact cttctgcaag atggaggaag accgcaaaac ttagtgccca   6780

tcacactgaa ggaagggatg tggttttttt tcctgcttct gtactgctac ctaactttgt   6840

gatttgcttt ggattttaat atttgtttct gttttagatt caagcccgta agttttgagg   6900

tgacttcagc tccattgtga aatagatagt tctcttcata tttcataact acatttcaat   6960

aattctaaac tttctacatt gatttttaga tacttatttt tcaagcttgg tttctcagct   7020

gatcagatga atttattcaa cttcaataca aagaaagaca aacctattat agtttcaagt   7080

gagtagatat tatactgtac aggacagcta tttgaacaca cacatcactg ctttagaaat   7140

aaaaccgcca atttataaat gtatatgacc tacattttat aggaaaaaat gtttttaaat   7200

gctagtcatt tatataatgt gctttgaagg atttgctagt ccacttctgt cactttttag   7260

tacactggta tcttttatat gtaatgtatg ctttttatta ttgtagcaaa gcatttcagt   7320

agaaagaatt ttgcaacaat atgggggaaa tttttcattg ttggatttga attatactgg   7380

attttatctg tgtagtctta cttgtcttta ttttaatgct gtctgaaggg aacttggtat   7440

ccaaataaag caggtaacct cattttactt caagggcata ctgtgtagtg ctgaatttaa   7500

tctgaaaatc tgatgatttt gaaaagaaaa acaagtttat aaacattgta cagaagaaat   7560

taaatgtgtg tgatggaaat cctgatggtg gagcacgttg aattttctga tatatagtgt   7620

tattttcctg ggatccccta tgccttcttt gtatttcaac taataaagga aaaaccctgt   7680

cattaaaact ggtaagataa taggatattc tgattataca gtattactat tcctatccca   7740

ttttctgacc ttttctcaat cactgtaaat ttttattttc tatttcctat tgataattaa   7800

atatgtacat aatatagaca ctgttgtata gaactaaatg aattgggttg ctatgcttga   7860

gtgggtagtg aaatggaaat atttgatgaa tactgagagt tcctaaaatg ctagagcaaa   7920

tttccgaggg aaaggggggc atcgtgtgtc ttgggaaggt tgcagcaggt tgtttcttca   7980

actccctaag aaatcattgg gaaggactca actgcaaact cgggatcaga tacaaaatgg   8040

gtctttcctt cccctctccc ccaaaaaata ggagcactaa attttaaaat ctactcaggt   8100

gacagttgct ttgcaatgaa acttatcaca ttgaaatttt cagtgttaaa taaaaagaga   8160

tttgtgatat ttttaaatat aaacttttac atcagtagtc agcagcctga caattgaaat   8220

ttggtaagtc gatatatttt aaaatatttt gctctccaaa tagaattgtt tttaaacaat   8280

tgggaggttt tttgtttctt taaatatgtt ttaattgtca ttgtaaaaac aaaatcttgc   8340

ttgaccctat attatgccat gaatgaattg ctgagccttt ataatacagt gacagcttgt   8400

ttcatgcata gtcatggaac atagagatgt tctttaaact gacctattga taagaggttt   8460

aatgagtttc acggctttca acactattgt catatagtta tctttgccat ttggagttta   8520

taaaaccatt ttatgtattg tgatactaaa ggaagttgtt ttgctttact ttaaattgaa   8580

ttattagact aatatttgca aattctgcat tttaaatgtg gacactggct gtttgaaaaa   8640

taaaatatag aatacagttt tatggataat tttcgagctg aatttttcac aatattctga   8700

accaaataac gaatggtaaa tatgcaaaaa tcatggtgca tagatataac cgtaaagaga   8760

aaagaatttc tgtgtggaat taacagttac acaaattggg taacaattat cagggccttt   8820

attatagctt tatgtggaat gttattctaa aatgcaagag tcaaatgtta ctgtcattga   8880

atattttaga cttgaaacgt gtttatcata gagcgaagaa aatatgtgtt cttttcttta   8940

cagataagac tctgttaacc cactgtcagc atacgtggga tttcttttct tttttctttc   9000

attagtggag atttgttttc atccatctac caccttgcca gtaccctagc ttgtgaccag   9060

cgggatgcat tgtaagaaag ttgtctgtgg ttaggagtgc agtctgggtc catggaacaa   9120

atttaaacta attggccctc gcaatgatca gtcctaggac cctggcctta ttattagcat   9180

ggtgctttaa ccaattgtac ataataatac cactgatagt ctactaatgc atttcctaga   9240

tcccagtttt tcttgaatga ttaggaatgg tggggagagg ggaggggaga tattctacat   9300

gatacttctc caatcttcta aagattataa gaaaaaataa aaaattgaag tcacttgaat   9360

taatgtgttg tcattgagtc ttactcgaca atttatcatg cacaaagtga ttatgaagat   9420

tttcctgatt atatgtttgg attgaattta aaaatttttt ttttcag                 9467


<210>  1731
<211>  794
<212>  PRT
<213>  Homo sapiens

<400>  1731


Met Asn Ile Asp Asp Lys Leu Glu Gly Leu Phe Leu Lys Cys Gly Gly 
1               5                   10                  15      


Ile Asp Glu Met Gln Ser Ser Arg Thr Met Val Val Met Gly Gly Val 
            20                  25                  30          


Ser Gly Gln Ser Thr Val Ser Gly Glu Leu Gln Asp Ser Val Leu Gln 
        35                  40                  45              


Asp Arg Ser Met Pro His Gln Glu Ile Leu Ala Ala Asp Glu Val Leu 
    50                  55                  60                  


Gln Glu Ser Glu Met Arg Gln Gln Asp Met Ile Ser His Asp Glu Leu 
65                  70                  75                  80  


Met Val His Glu Glu Thr Val Lys Asn Asp Glu Glu Gln Met Glu Thr 
                85                  90                  95      


His Glu Arg Leu Pro Gln Gly Leu Gln Tyr Ala Leu Asn Val Pro Ile 
            100                 105                 110         


Ser Val Lys Gln Glu Ile Thr Phe Thr Asp Val Ser Glu Gln Leu Met 
        115                 120                 125             


Arg Asp Lys Lys Gln Ile Arg Glu Pro Val Asp Leu Gln Lys Lys Lys 
    130                 135                 140                 


Lys Arg Lys Gln Arg Ser Pro Ala Lys Ile Leu Thr Ile Asn Glu Asp 
145                 150                 155                 160 


Gly Ser Leu Gly Leu Lys Thr Pro Lys Ser His Val Cys Glu His Cys 
                165                 170                 175     


Asn Ala Ala Phe Arg Thr Asn Tyr His Leu Gln Arg His Val Phe Ile 
            180                 185                 190         


His Thr Gly Glu Lys Pro Phe Gln Cys Ser Gln Cys Asp Met Arg Phe 
        195                 200                 205             


Ile Gln Lys Tyr Leu Leu Gln Arg His Glu Lys Ile His Thr Gly Glu 
    210                 215                 220                 


Lys Pro Phe Arg Cys Asp Glu Cys Gly Met Arg Phe Ile Gln Lys Tyr 
225                 230                 235                 240 


His Met Glu Arg His Lys Arg Thr His Ser Gly Glu Lys Pro Tyr Gln 
                245                 250                 255     


Cys Glu Tyr Cys Leu Gln Tyr Phe Ser Arg Thr Asp Arg Val Leu Lys 
            260                 265                 270         


His Lys Arg Met Cys His Glu Asn His Asp Lys Lys Leu Asn Arg Cys 
        275                 280                 285             


Ala Ile Lys Gly Gly Leu Leu Thr Ser Glu Glu Asp Ser Gly Phe Ser 
    290                 295                 300                 


Thr Ser Pro Lys Asp Asn Ser Leu Pro Lys Lys Lys Arg Gln Lys Thr 
305                 310                 315                 320 


Glu Lys Lys Ser Ser Gly Met Asp Lys Glu Ser Ala Leu Asp Lys Ser 
                325                 330                 335     


Asp Leu Lys Lys Asp Lys Asn Asp Tyr Leu Pro Leu Tyr Ser Ser Ser 
            340                 345                 350         


Thr Lys Val Lys Asp Glu Tyr Met Val Ala Glu Tyr Ala Val Glu Met 
        355                 360                 365             


Pro His Ser Ser Val Gly Gly Ser His Leu Glu Asp Ala Ser Gly Glu 
    370                 375                 380                 


Ile His Pro Pro Lys Leu Val Leu Lys Lys Ile Asn Ser Lys Arg Ser 
385                 390                 395                 400 


Leu Lys Gln Pro Leu Glu Gln Asn Gln Thr Ile Ser Pro Leu Ser Thr 
                405                 410                 415     


Tyr Glu Glu Ser Lys Val Ser Lys Tyr Ala Phe Glu Leu Val Asp Lys 
            420                 425                 430         


Gln Ala Leu Leu Asp Ser Glu Gly Asn Ala Asp Ile Asp Gln Val Asp 
        435                 440                 445             


Asn Leu Gln Glu Gly Pro Ser Lys Pro Val His Ser Ser Thr Asn Tyr 
    450                 455                 460                 


Asp Asp Ala Met Gln Phe Leu Lys Lys Lys Arg Tyr Leu Gln Ala Ala 
465                 470                 475                 480 


Ser Asn Asn Ser Arg Glu Tyr Ala Leu Asn Val Gly Thr Ile Ala Ser 
                485                 490                 495     


Gln Pro Ser Val Thr Gln Ala Ala Val Ala Ser Val Ile Asp Glu Ser 
            500                 505                 510         


Thr Thr Ala Ser Ile Leu Glu Ser Gln Ala Leu Asn Val Glu Ile Lys 
        515                 520                 525             


Ser Asn His Asp Lys Asn Val Ile Pro Asp Glu Val Leu Gln Thr Leu 
    530                 535                 540                 


Leu Asp His Tyr Ser His Lys Ala Asn Gly Gln His Glu Ile Ser Phe 
545                 550                 555                 560 


Ser Val Ala Asp Thr Glu Val Thr Ser Ser Ile Ser Ile Asn Ser Ser 
                565                 570                 575     


Glu Val Pro Glu Val Thr Pro Ser Glu Asn Val Gly Ser Ser Ser Gln 
            580                 585                 590         


Ala Ser Ser Ser Asp Lys Ala Asn Met Leu Gln Glu Tyr Ser Lys Phe 
        595                 600                 605             


Leu Gln Gln Ala Leu Asp Arg Thr Ser Gln Asn Asp Ala Tyr Leu Asn 
    610                 615                 620                 


Ser Pro Ser Leu Asn Phe Val Thr Asp Asn Gln Thr Leu Pro Asn Gln 
625                 630                 635                 640 


Pro Ala Phe Ser Ser Ile Asp Lys Gln Val Tyr Ala Thr Met Pro Ile 
                645                 650                 655     


Asn Ser Phe Arg Ser Gly Met Asn Ser Pro Leu Arg Thr Thr Pro Asp 
            660                 665                 670         


Lys Ser His Phe Gly Leu Ile Val Gly Asp Ser Gln His Ser Phe Pro 
        675                 680                 685             


Phe Ser Gly Asp Glu Thr Asn His Ala Ser Ala Thr Ser Thr Gln Asp 
    690                 695                 700                 


Phe Leu Asp Gln Val Thr Ser Gln Lys Lys Ala Glu Ala Gln Pro Val 
705                 710                 715                 720 


His Gln Ala Tyr Gln Met Ser Ser Phe Glu Gln Pro Phe Arg Ala Pro 
                725                 730                 735     


Tyr His Gly Ser Arg Ala Gly Ile Ala Thr Gln Phe Ser Thr Ala Asn 
            740                 745                 750         


Gly Gln Val Asn Leu Arg Gly Pro Gly Thr Ser Ala Glu Phe Ser Glu 
        755                 760                 765             


Phe Pro Leu Val Asn Val Asn Asp Asn Arg Ala Gly Met Thr Ser Ser 
    770                 775                 780                 


Pro Asp Ala Thr Thr Gly Gln Thr Phe Gly 
785                 790                 

<210>  1732
<211>  9467
<212>  DNA
<213>  Homo sapiens

<400>  1732
ggagaaaggc gcaggggtgg gagctgttgc cgaagctgcc acagcaaaag ttctcccccc     60

tccccccttc ccctcctctc aaggccccta gaaaggttgg agctgccgcc gcctgcagtc    120

ggtgaccgcg cgactcggcg cccgcccgcg gaatcggatg gcataagtga ttaaggtggt    180

attgaggatt tctgaagcct atgaaaggta gaaactcaac catgatttct ttttcaactc    240

tacagcattc ctttccttga agtcttcgtt tttaccttag tctcgggcag ttatacttaa    300

gcatgaacat tgacgacaaa ctggaaggat tgtttcttaa atgtggcggc atagacgaaa    360

tgcagtcttc caggacaatg gttgtaatgg gtggagtgtc tggccagtct actgtgtctg    420

gagagctaca ggattcagta cttcaagatc gaagtatgcc tcaccaggag atccttgctg    480

cagatgaagt gttacaagaa agtgaaatga gacaacagga tatgatatca catgatgaac    540

tcatggtcca tgaggagaca gtgaaaaatg atgaagagca gatggaaaca catgaaagac    600

ttcctcaagg actacagtat gcacttaatg tccctataag cgtaaagcag gaaattactt    660

ttactgatgt atctgagcaa ctgatgagag acaaaaaaca aatcagagag ccagtagact    720

tacagaaaaa gaagaagcgg aaacaacgtt ctcccgcaaa aatccttaca ataaatgagg    780

atggatcact tggtttgaaa acccctaaat ctcacgtttg tgagcactgc aatgctgcct    840

ttagaacgaa ctatcactta cagagacatg tcttcattca tacaggtgaa aaaccatttc    900

aatgtagtca atgtgacatg cgtttcatac agaagtacct gcttcagaga catgagaaga    960

ttcatactgg tgaaaaacca tttcgctgtg atgaatgtgg tatgagattc atacaaaaat   1020

atcatatgga aaggcataag agaactcata gtggagaaaa accttaccag tgtgaatact   1080

gtttacagta tttttccaga acagatcgtg tattgaaaca taaacgtatg tgccatgaaa   1140

atcatgacaa aaaactaaat agatgtgcca tcaaaggtgg ccttctgaca tctgaggaag   1200

attctggctt ttctacatca ccaaaagaca actcactgcc aaaaaagaaa aggcagaaaa   1260

cggagaaaaa atcatctgga atggacaaag agagtgcttt ggacaaatct gacctgaaaa   1320

aagacaaaaa tgattacttg cctctttatt cttcaagtac taaagtaaaa gatgagtata   1380

tggttgcaga atatgctgtt gaaatgccac attcgtcagt tgggggctcg catttagaag   1440

atgcgtcagg agaaatacac ccacctaagt tagttctcaa aaaaattaat agtaagagaa   1500

gtctgaaaca gccactggag caaaatcaaa caatttcacc tttatccaca tatgaagaga   1560

gcaaagtttc aaagtatgct tttgaacttg tggataaaca ggctttactg gactcagaag   1620

gcaatgctga cattgatcag gttgataatt tgcaggaggg gcccagtaaa cctgtgcata   1680

gtagtactaa ttatgatgat gccatgcagt ttttgaagaa gaagcggtat cttcaagcag   1740

caagtaacaa cagcagggaa tatgcgctga atgtgggtac catagcttct cagccttctg   1800

taacacaagc agctgtggca agtgtcattg atgaaagtac cacggcatcc atattagagt   1860

cacaggcact gaatgtggag attaagagta atcatgacaa aaatgttatt ccagatgagg   1920

tactgcagac tctgttggat cattattccc acaaagctaa tggacagcat gagatatcct   1980

tcagtgttgc agatactgaa gtgacttcta gcatatcaat aaattcttca gaagtaccag   2040

aggtcacccc gtcagagaat gttggatcaa gctcccaagc atcctcatca gataaagcca   2100

acatgttgca ggaatactcc aagtttctgc agcaggcttt ggacagaact agccaaaatg   2160

atgcctattt gaatagcccg agccttaact ttgtgactga taaccagacc ctcccaaatc   2220

agccagcatt ctcttccata gacaagcagg tctatgccac catgcccatc aatagctttc   2280

gatcaggaat gaattctcca ctaagaacaa ctccagataa gtcccacttt ggactaatag   2340

ttggtgattc acagcactca tttccctttt caggtgatga gacaaaccat gcttctgcca   2400

catcaacaca ggactttctg gatcaagtga cttctcagaa gaaagctgag gcccagcctg   2460

tccaccaagc ttaccaaatg agctcctttg aacagccctt ccgtgctccc tatcatggat   2520

caagagctgg aatagctact caatttagca ctgccaatgg acaggtgaac cttcggggac   2580

cagggacaag tgctgaattt tcagaatttc ccttggtgaa tgtaaatgat aatagagctg   2640

ggatgacatc ttcacctgat gccacaactg gccagacttt tggctaaaaa aaaaaaaaaa   2700

gtgtaaataa tactggcact ttagaacaga ttaatcaaga gtggggttac tctgtgtaaa   2760

tggagtgctg tacagattta agagcaatgc gtaataacaa gttaagctga tatgaatagc   2820

aagataatcc aataactgca tttcgtttgg ttagtcagca ttctttgaac tgccttacat   2880

gttgtcacct ttatagaagc aatgcattac ttgttttaga tcagaaactt gctattccac   2940

ccacaccaag ttaaaaagga aaaaaaaaag actttcgcac aattgtttcc taactgataa   3000

cattgtacat tcttaggaga ttagtaattg tgtgaaattt actcatactg tttctaagtt   3060

tttcagcata gtcattgcac ttcagcaggg aatctgagta tactttacag acagagtgaa   3120

cttaaaagtt taatgtcaag agattatggc ttaaataaat tagtgtgtcc tataggggga   3180

aaaaaaccaa gaaaccacct tttaaaaaga atgatatgcc atataccctt gattttcatt   3240

ttgcattata ttgacgtgtt tttttgaagg aaaaaaagta ataaaaatct gatagtctaa   3300

gactccacta tttaaaagcc taattacttt aaaaatatgc atactttcag aacttttacc   3360

aaaacacaca actgttgaag cagtcacttc tctatggaag tatgcatatt ggtgtcagtt   3420

tctttgtaca gttgtactta gatatttttt atgatttttc atgtgcaggt atcaaggttt   3480

tgaagtttta gtaaaagaaa ttctgtagat tacattccca agaacataat gcttacacaa   3540

aatgtatatt ccacgtttta aagcttaatt gtattttact ttacatatac acttcagtta   3600

acatagagca cttagaatct atttggtatt tttgatttct caaagtaaaa aaaaaattag   3660

atttttaggt ttgatatggt tgtgtcataa tcatctcgta attgacaatt ttaacttttg   3720

gcaataaaag gaaattggga tatctttgga actgtaaaac ctggtttaat ctttttcttt   3780

ctagactctt gatagattgg ataattaaac agtatccaga gaaactaaag aaatgggcat   3840

tttaattgca tattttatct tgagttactt tttaatgaac actgctcatt acaactttac   3900

aaaccaaaag tgtttactaa ttccagtaac taccatttct ttttcagcta gatgagtgat   3960

cggaaaattt ttgttgcatt tcaaaatcta aataaactac agactttatc cttataccat   4020

gaatgttttt ttttaatact ctgtcttaaa ataatacagc atggtacaat aaatagtgct   4080

tttatgtata tatacacaca cacacttttc tgaagaatga tggtttgagt tatgcgttgg   4140

gcagttttga tttttggaag ttatattagt tattgactct ttgttacaac tttttcattt   4200

ttacatttta aattttctgc catcgttgtc acaatgcaca tcctgatata gcaccagtga   4260

aaatctaaaa ttaataccct tggaaaatga aaatattctt aatttccatt ttgactctta   4320

tactggccct atagctctgc agtctttgtt tcaatataga atatgttatc catttaaatt   4380

attttttctt ttatttaatg ttatcccaag actgttctca taaagaaagg gaagaaataa   4440

ctatccaccc ttaacatcct tcatttattt tgaatatatt ggtgttttta tgataaggaa   4500

tataaattat atttaatgtg gtttcctgta tactttggtt attaagtttt gcttgaaata   4560

gtagttttcc cgtttgacag ctttctttgc tgccaaagtt ttcaagaatt taagacttct   4620

ttgaagtaaa tatttaagtt ctgccattat tgactcttaa gattgtgtgt gttgtgttgt   4680

gcattacata attacaaaaa ggcttcattc aggtgatacg ttaaaaatgg aactgtgctc   4740

accctaaata ggcattggta tttttctctt ttggtgagag taggcattta tttcttgagt   4800

tgttttggag cctgatcaaa aattttgttc atggagaact tgatgcaatt ttgatacagt   4860

ggagaggttt ttttcggttg ttttaacatc accagcatag tttttagaat gtgactcttg   4920

ctgagcattt agggtgagct tgggaaggaa ggcctttgaa aatggtagtt atgcaagcag   4980

actttcaggt gttgcattcc tgttttcaac acatttcttt aaatctacat aatggcagac   5040

ttttctacca ggttataagc agtttttaga taagtgatac tcagccagca taacttattg   5100

acttaccatt tacgtatagt catcactctc ttactgtgaa attccaaatg cctaccagag   5160

ttaccttgtt ctatcataat atgacaaaca tctcaacagt tttggatttc cccactttgg   5220

ttcagaaggt tatttaattt ctatctgggc attaatggag aaaataagta gccttgtgtg   5280

ctgcttcaga ttgaaacatg gaggatatga gatattcttc tgcaattcat gtttctcatt   5340

tctcaaagtg agcacattgt tctataaaaa catgctggta cacccttaaa cttttgatca   5400

atctgagtga ggtgtgcttt tcctcttggg acctactcac gtttgaagat tggaaacatc   5460

acgttaggcg aggcagtatc tcttgaacat cttctaaagg gttttttaaa accttattct   5520

cacatatttc atttgtcttg aatatttaag tggctcttaa acgttttggg tctacatgca   5580

aatgtggtac ttaacaaggt aggaatccat cttcttagct ctggctgagg gtgccagcca   5640

tcggtcaggt catttttatc tcaagaggca gaaggcagtt atgtcaagaa ttgtgctcag   5700

ggcaggattt cgtttccaca gaggagagac acttgcagag tgccagctag gttagatctt   5760

ttgccgcttc tttcatttga ttaatttggg tttttaaagg gctgtttaaa aaaaaaaaaa   5820

aaaggccggg aaactttaaa agtaggcatt actgtagtac tgcatttctt agaacatttt   5880

aaactagaac tcattttttt ttcacagtat atttacttga agaagcacta taataatcat   5940

tgagaagtat tttgagtctg aaatttaatt taattttccg tttcaaattg ctttatttca   6000

gggaaataat tttccagttg ttttgctata ttctgcaaat aaaaaccgtg tttccttttt   6060

tcacttaaac tttggtagga aacaaactaa agcagacaaa catttcttgt tatgtttgtt   6120

gctttcttta atccaatgga taaaaaagta aaaccctgta aacattattt tattttttta   6180

tgcaatacca tgctgtaaat atggttcatc aaataaggat gtacctatga ttgaatcttt   6240

aattctgcac agttagagtt tatatataaa cgtgtcttga caatcaagga cttttatgtg   6300

agtcttcctt tatgatgttt attaatgtta tgcattccat ttgttttgaa gtgagtacca   6360

atgtgctaat ttgtattgtc tgaaagtatg taatgttttt acagcttgtt tttaagaatc   6420

tgtaaatatg tacaaacaaa tcacagtact gctttatgtt agaaggcata tgatgttgta   6480

ctgtatgtaa gcaataatac atagcagtgc taactttaca agtagcatca ggaaagttct   6540

aaaaacattt cagagttatt aattatcctt atttcattta ataatgatta tctttaatca   6600

gtttttataa gcaaattcca ttgttcctcc tattggaacg taacactgtt tacacagcat   6660

aattgaagtt gcaggggaga caggctaaat ctgacttcat ctgtactcac tttcactaag   6720

cattgaatgg ccttaccact cttctgcaag atggaggaag accgcaaaac ttagtgccca   6780

tcacactgaa ggaagggatg tggttttttt tcctgcttct gtactgctac ctaactttgt   6840

gatttgcttt ggattttaat atttgtttct gttttagatt caagcccgta agttttgagg   6900

tgacttcagc tccattgtga aatagatagt tctcttcata tttcataact acatttcaat   6960

aattctaaac tttctacatt gatttttaga tacttatttt tcaagcttgg tttctcagct   7020

gatcagatga atttattcaa cttcaataca aagaaagaca aacctattat agtttcaagt   7080

gagtagatat tatactgtac aggacagcta tttgaacaca cacatcactg ctttagaaat   7140

aaaaccgcca atttataaat gtatatgacc tacattttat aggaaaaaat gtttttaaat   7200

gctagtcatt tatataatgt gctttgaagg atttgctagt ccacttctgt cactttttag   7260

tacactggta tcttttatat gtaatgtatg ctttttatta ttgtagcaaa gcatttcagt   7320

agaaagaatt ttgcaacaat atgggggaaa tttttcattg ttggatttga attatactgg   7380

attttatctg tgtagtctta cttgtcttta ttttaatgct gtctgaaggg aacttggtat   7440

ccaaataaag caggtaacct cattttactt caagggcata ctgtgtagtg ctgaatttaa   7500

tctgaaaatc tgatgatttt gaaaagaaaa acaagtttat aaacattgta cagaagaaat   7560

taaatgtgtg tgatggaaat cctgatggtg gagcacgttg aattttctga tatatagtgt   7620

tattttcctg ggatccccta tgccttcttt gtatttcaac taataaagga aaaaccctgt   7680

cattaaaact ggtaagataa taggatattc tgattataca gtattactat tcctatccca   7740

ttttctgacc ttttctcaat cactgtaaat ttttattttc tatttcctat tgataattaa   7800

atatgtacat aatatagaca ctgttgtata gaactaaatg aattgggttg ctatgcttga   7860

gtgggtagtg aaatggaaat atttgatgaa tactgagagt tcctaaaatg ctagagcaaa   7920

tttccgaggg aaaggggggc atcgtgtgtc ttgggaaggt tgcagcaggt tgtttcttca   7980

actccctaag aaatcattgg gaaggactca actgcaaact cgggatcaga tacaaaatgg   8040

gtctttcctt cccctctccc ccaaaaaata ggagcactaa attttaaaat ctactcaggt   8100

gacagttgct ttgcaatgaa acttatcaca ttgaaatttt cagtgttaaa taaaaagaga   8160

tttgtgatat ttttaaatat aaacttttac atcagtagtc agcagcctga caattgaaat   8220

ttggtaagtc gatatatttt aaaatatttt gctctccaaa tagaattgtt tttaaacaat   8280

tgggaggttt tttgtttctt taaatatgtt ttaattgtca ttgtaaaaac aaaatcttgc   8340

ttgaccctat attatgccat gaatgaattg ctgagccttt ataatacagt gacagcttgt   8400

ttcatgcata gtcatggaac atagagatgt tctttaaact gacctattga taagaggttt   8460

aatgagtttc acggctttca acactattgt catatagtta tctttgccat ttggagttta   8520

taaaaccatt ttatgtattg tgatactaaa ggaagttgtt ttgctttact ttaaattgaa   8580

ttattagact aatatttgca aattctgcat tttaaatgtg gacactggct gtttgaaaaa   8640

taaaatatag aatacagttt tatggataat tttcgagctg aatttttcac aatattctga   8700

accaaataac gaatggtaaa tatgcaaaaa tcatggtgca tagatataac cgtaaagaga   8760

aaagaatttc tgtgtggaat taacagttac acaaattggg taacaattat cagggccttt   8820

attatagctt tatgtggaat gttattctaa aatgcaagag tcaaatgtta ctgtcattga   8880

atattttaga cttgaaacgt gtttatcata gagcgaagaa aatatgtgtt cttttcttta   8940

cagataagac tctgttaacc cactgtcagc atacgtggga tttcttttct tttttctttc   9000

attagtggag atttgttttc atccatctac caccttgcca gtaccctagc ttgtgaccag   9060

cgggatgcat tgtaagaaag ttgtctgtgg ttaggagtgc agtctgggtc catggaacaa   9120

atttaaacta attggccctc gcaatgatca gtcctaggac cctggcctta ttattagcat   9180

ggtgctttaa ccaattgtac ataataatac cactgatagt ctactaatgc atttcctaga   9240

tcccagtttt tcttgaatga ttaggaatgg tggggagagg ggaggggaga tattctacat   9300

gatacttctc caatcttcta aagattataa gaaaaaataa aaaattgaag tcacttgaat   9360

taatgtgttg tcattgagtc ttactcgaca atttatcatg cacaaagtga ttatgaagat   9420

tttcctgatt atatgtttgg attgaattta aaaatttttt ttttcag                 9467


<210>  1733
<211>  794
<212>  PRT
<213>  Homo sapiens

<400>  1733


Met Asn Ile Asp Asp Lys Leu Glu Gly Leu Phe Leu Lys Cys Gly Gly 
1               5                   10                  15      


Ile Asp Glu Met Gln Ser Ser Arg Thr Met Val Val Met Gly Gly Val 
            20                  25                  30          


Ser Gly Gln Ser Thr Val Ser Gly Glu Leu Gln Asp Ser Val Leu Gln 
        35                  40                  45              


Asp Arg Ser Met Pro His Gln Glu Ile Leu Ala Ala Asp Glu Val Leu 
    50                  55                  60                  


Gln Glu Ser Glu Met Arg Gln Gln Asp Met Ile Ser His Asp Glu Leu 
65                  70                  75                  80  


Met Val His Glu Glu Thr Val Lys Asn Asp Glu Glu Gln Met Glu Thr 
                85                  90                  95      


His Glu Arg Leu Pro Gln Gly Leu Gln Tyr Ala Leu Asn Val Pro Ile 
            100                 105                 110         


Ser Val Lys Gln Glu Ile Thr Phe Thr Asp Val Ser Glu Gln Leu Met 
        115                 120                 125             


Arg Asp Lys Lys Gln Ile Arg Glu Pro Val Asp Leu Gln Lys Lys Lys 
    130                 135                 140                 


Lys Arg Lys Gln Arg Ser Pro Ala Lys Ile Leu Thr Ile Asn Glu Asp 
145                 150                 155                 160 


Gly Ser Leu Gly Leu Lys Thr Pro Lys Ser His Val Cys Glu His Cys 
                165                 170                 175     


Asn Ala Ala Phe Arg Thr Asn Tyr His Leu Gln Arg His Val Phe Ile 
            180                 185                 190         


His Thr Gly Glu Lys Pro Phe Gln Cys Ser Gln Cys Asp Met Arg Phe 
        195                 200                 205             


Ile Gln Lys Tyr Leu Leu Gln Arg His Glu Lys Ile His Thr Gly Glu 
    210                 215                 220                 


Lys Pro Phe Arg Cys Asp Glu Cys Gly Met Arg Phe Ile Gln Lys Tyr 
225                 230                 235                 240 


His Met Glu Arg His Lys Arg Thr His Ser Gly Glu Lys Pro Tyr Gln 
                245                 250                 255     


Cys Glu Tyr Cys Leu Gln Tyr Phe Ser Arg Thr Asp Arg Val Leu Lys 
            260                 265                 270         


His Lys Arg Met Cys His Glu Asn His Asp Lys Lys Leu Asn Arg Cys 
        275                 280                 285             


Ala Ile Lys Gly Gly Leu Leu Thr Ser Glu Glu Asp Ser Gly Phe Ser 
    290                 295                 300                 


Thr Ser Pro Lys Asp Asn Ser Leu Pro Lys Lys Lys Arg Gln Lys Thr 
305                 310                 315                 320 


Glu Lys Lys Ser Ser Gly Met Asp Lys Glu Ser Ala Leu Asp Lys Ser 
                325                 330                 335     


Asp Leu Lys Lys Asp Lys Asn Asp Tyr Leu Pro Leu Tyr Ser Ser Ser 
            340                 345                 350         


Thr Lys Val Lys Asp Glu Tyr Met Val Ala Glu Tyr Ala Val Glu Met 
        355                 360                 365             


Pro His Ser Ser Val Gly Gly Ser His Leu Glu Asp Ala Ser Gly Glu 
    370                 375                 380                 


Ile His Pro Pro Lys Leu Val Leu Lys Lys Ile Asn Ser Lys Arg Ser 
385                 390                 395                 400 


Leu Lys Gln Pro Leu Glu Gln Asn Gln Thr Ile Ser Pro Leu Ser Thr 
                405                 410                 415     


Tyr Glu Glu Ser Lys Val Ser Lys Tyr Ala Phe Glu Leu Val Asp Lys 
            420                 425                 430         


Gln Ala Leu Leu Asp Ser Glu Gly Asn Ala Asp Ile Asp Gln Val Asp 
        435                 440                 445             


Asn Leu Gln Glu Gly Pro Ser Lys Pro Val His Ser Ser Thr Asn Tyr 
    450                 455                 460                 


Asp Asp Ala Met Gln Phe Leu Lys Lys Lys Arg Tyr Leu Gln Ala Ala 
465                 470                 475                 480 


Ser Asn Asn Ser Arg Glu Tyr Ala Leu Asn Val Gly Thr Ile Ala Ser 
                485                 490                 495     


Gln Pro Ser Val Thr Gln Ala Ala Val Ala Ser Val Ile Asp Glu Ser 
            500                 505                 510         


Thr Thr Ala Ser Ile Leu Glu Ser Gln Ala Leu Asn Val Glu Ile Lys 
        515                 520                 525             


Ser Asn His Asp Lys Asn Val Ile Pro Asp Glu Val Leu Gln Thr Leu 
    530                 535                 540                 


Leu Asp His Tyr Ser His Lys Ala Asn Gly Gln His Glu Ile Ser Phe 
545                 550                 555                 560 


Ser Val Ala Asp Thr Glu Val Thr Ser Ser Ile Ser Ile Asn Ser Ser 
                565                 570                 575     


Glu Val Pro Glu Val Thr Pro Ser Glu Asn Val Gly Ser Ser Ser Gln 
            580                 585                 590         


Ala Ser Ser Ser Asp Lys Ala Asn Met Leu Gln Glu Tyr Ser Lys Phe 
        595                 600                 605             


Leu Gln Gln Ala Leu Asp Arg Thr Ser Gln Asn Asp Ala Tyr Leu Asn 
    610                 615                 620                 


Ser Pro Ser Leu Asn Phe Val Thr Asp Asn Gln Thr Leu Pro Asn Gln 
625                 630                 635                 640 


Pro Ala Phe Ser Ser Ile Asp Lys Gln Val Tyr Ala Thr Met Pro Ile 
                645                 650                 655     


Asn Ser Phe Arg Ser Gly Met Asn Ser Pro Leu Arg Thr Thr Pro Asp 
            660                 665                 670         


Lys Ser His Phe Gly Leu Ile Val Gly Asp Ser Gln His Ser Phe Pro 
        675                 680                 685             


Phe Ser Gly Asp Glu Thr Asn His Ala Ser Ala Thr Ser Thr Gln Asp 
    690                 695                 700                 


Phe Leu Asp Gln Val Thr Ser Gln Lys Lys Ala Glu Ala Gln Pro Val 
705                 710                 715                 720 


His Gln Ala Tyr Gln Met Ser Ser Phe Glu Gln Pro Phe Arg Ala Pro 
                725                 730                 735     


Tyr His Gly Ser Arg Ala Gly Ile Ala Thr Gln Phe Ser Thr Ala Asn 
            740                 745                 750         


Gly Gln Val Asn Leu Arg Gly Pro Gly Thr Ser Ala Glu Phe Ser Glu 
        755                 760                 765             


Phe Pro Leu Val Asn Val Asn Asp Asn Arg Ala Gly Met Thr Ser Ser 
    770                 775                 780                 


Pro Asp Ala Thr Thr Gly Gln Thr Phe Gly 
785                 790                 

<210>  1734
<211>  7523
<212>  DNA
<213>  Homo sapiens

<400>  1734
ggaggaggag gaggaggggg aggaagagga gaaaggcgca ggggtgggag ctgttgccga     60

agctgccaca gcaaaagttc tcccccctcc ccccttcccc tcctctcaag gcccctagaa    120

aggttggagc tgccgccgcc tgcagtcggt gaccgcgcga ctcggcgccc gcccgcggat    180

agagggagga atcagcagct tggaaattca agcacgtgat ctggcgggat gggcgtttgc    240

ctaacgtatt taatggagga atcggatggc ataagtgatt aaggtggtat tgaggatttc    300

tgaagcctat gaaaggtgaa aaaccatttc aatgtagtca atgtgacatg cgtttcatac    360

agaagtacct gcttcagaga catgagaaga ttcatactgg tgaaaaacca tttcgctgtg    420

atgaatgtgg tgatgagaca aaccatgctt ctgccacatc aacacaggac tttctggatc    480

aagtgacttc tcagaagaaa gctgaggccc agcctgtcca ccaagcttac caaatgagct    540

cctttgaaca gcccttccgt gctccctatc atggatcaag agctggaata gctactcaat    600

ttagcactgc caatggacag gtgaaccttc ggggaccagg gacaagtgct gaattttcag    660

aatttccctt ggtgaatgta aatgataata gagctgggat gacatcttca cctgatgcca    720

caactggcca gacttttggc taaaaaaaaa aaaaaagtgt aaataatact ggcactttag    780

aacagattaa tcaagagtgg ggttactctg tgtaaatgga gtgctgtaca gatttaagag    840

caatgcgtaa taacaagtta agctgatatg aatagcaaga taatccaata actgcatttc    900

gtttggttag tcagcattct ttgaactgcc ttacatgttg tcacctttat agaagcaatg    960

cattacttgt tttagatcag aaacttgcta ttccacccac accaagttaa aaaggaaaaa   1020

aaaaagactt tcgcacaatt gtttcctaac tgataacatt gtacattctt aggagattag   1080

taattgtgtg aaatttactc atactgtttc taagtttttc agcatagtca ttgcacttca   1140

gcagggaatc tgagtatact ttacagacag agtgaactta aaagtttaat gtcaagagat   1200

tatggcttaa ataaattagt gtgtcctata gggggaaaaa aaccaagaaa ccacctttta   1260

aaaagaatga tatgccatat acccttgatt ttcattttgc attatattga cgtgtttttt   1320

tgaaggaaaa aaagtaataa aaatctgata gtctaagact ccactattta aaagcctaat   1380

tactttaaaa atatgcatac tttcagaact tttaccaaaa cacacaactg ttgaagcagt   1440

cacttctcta tggaagtatg catattggtg tcagtttctt tgtacagttg tacttagata   1500

ttttttatga tttttcatgt gcaggtatca aggttttgaa gttttagtaa aagaaattct   1560

gtagattaca ttcccaagaa cataatgctt acacaaaatg tatattccac gttttaaagc   1620

ttaattgtat tttactttac atatacactt cagttaacat agagcactta gaatctattt   1680

ggtatttttg atttctcaaa gtaaaaaaaa aattagattt ttaggtttga tatggttgtg   1740

tcataatcat ctcgtaattg acaattttaa cttttggcaa taaaaggaaa ttgggatatc   1800

tttggaactg taaaacctgg tttaatcttt ttctttctag actcttgata gattggataa   1860

ttaaacagta tccagagaaa ctaaagaaat gggcatttta attgcatatt ttatcttgag   1920

ttacttttta atgaacactg ctcattacaa ctttacaaac caaaagtgtt tactaattcc   1980

agtaactacc atttcttttt cagctagatg agtgatcgga aaatttttgt tgcatttcaa   2040

aatctaaata aactacagac tttatcctta taccatgaat gttttttttt aatactctgt   2100

cttaaaataa tacagcatgg tacaataaat agtgctttta tgtatatata cacacacaca   2160

cttttctgaa gaatgatggt ttgagttatg cgttgggcag ttttgatttt tggaagttat   2220

attagttatt gactctttgt tacaactttt tcatttttac attttaaatt ttctgccatc   2280

gttgtcacaa tgcacatcct gatatagcac cagtgaaaat ctaaaattaa tacccttgga   2340

aaatgaaaat attcttaatt tccattttga ctcttatact ggccctatag ctctgcagtc   2400

tttgtttcaa tatagaatat gttatccatt taaattattt tttcttttat ttaatgttat   2460

cccaagactg ttctcataaa gaaagggaag aaataactat ccacccttaa catccttcat   2520

ttattttgaa tatattggtg tttttatgat aaggaatata aattatattt aatgtggttt   2580

cctgtatact ttggttatta agttttgctt gaaatagtag ttttcccgtt tgacagcttt   2640

ctttgctgcc aaagttttca agaatttaag acttctttga agtaaatatt taagttctgc   2700

cattattgac tcttaagatt gtgtgtgttg tgttgtgcat tacataatta caaaaaggct   2760

tcattcaggt gatacgttaa aaatggaact gtgctcaccc taaataggca ttggtatttt   2820

tctcttttgg tgagagtagg catttatttc ttgagttgtt ttggagcctg atcaaaaatt   2880

ttgttcatgg agaacttgat gcaattttga tacagtggag aggttttttt cggttgtttt   2940

aacatcacca gcatagtttt tagaatgtga ctcttgctga gcatttaggg tgagcttggg   3000

aaggaaggcc tttgaaaatg gtagttatgc aagcagactt tcaggtgttg cattcctgtt   3060

ttcaacacat ttctttaaat ctacataatg gcagactttt ctaccaggtt ataagcagtt   3120

tttagataag tgatactcag ccagcataac ttattgactt accatttacg tatagtcatc   3180

actctcttac tgtgaaattc caaatgccta ccagagttac cttgttctat cataatatga   3240

caaacatctc aacagttttg gatttcccca ctttggttca gaaggttatt taatttctat   3300

ctgggcatta atggagaaaa taagtagcct tgtgtgctgc ttcagattga aacatggagg   3360

atatgagata ttcttctgca attcatgttt ctcatttctc aaagtgagca cattgttcta   3420

taaaaacatg ctggtacacc cttaaacttt tgatcaatct gagtgaggtg tgcttttcct   3480

cttgggacct actcacgttt gaagattgga aacatcacgt taggcgaggc agtatctctt   3540

gaacatcttc taaagggttt tttaaaacct tattctcaca tatttcattt gtcttgaata   3600

tttaagtggc tcttaaacgt tttgggtcta catgcaaatg tggtacttaa caaggtagga   3660

atccatcttc ttagctctgg ctgagggtgc cagccatcgg tcaggtcatt tttatctcaa   3720

gaggcagaag gcagttatgt caagaattgt gctcagggca ggatttcgtt tccacagagg   3780

agagacactt gcagagtgcc agctaggtta gatcttttgc cgcttctttc atttgattaa   3840

tttgggtttt taaagggctg tttaaaaaaa aaaaaaaaag gccgggaaac tttaaaagta   3900

ggcattactg tagtactgca tttcttagaa cattttaaac tagaactcat ttttttttca   3960

cagtatattt acttgaagaa gcactataat aatcattgag aagtattttg agtctgaaat   4020

ttaatttaat tttccgtttc aaattgcttt atttcaggga aataattttc cagttgtttt   4080

gctatattct gcaaataaaa accgtgtttc cttttttcac ttaaactttg gtaggaaaca   4140

aactaaagca gacaaacatt tcttgttatg tttgttgctt tctttaatcc aatggataaa   4200

aaagtaaaac cctgtaaaca ttattttatt tttttatgca ataccatgct gtaaatatgg   4260

ttcatcaaat aaggatgtac ctatgattga atctttaatt ctgcacagtt agagtttata   4320

tataaacgtg tcttgacaat caaggacttt tatgtgagtc ttcctttatg atgtttatta   4380

atgttatgca ttccatttgt tttgaagtga gtaccaatgt gctaatttgt attgtctgaa   4440

agtatgtaat gtttttacag cttgttttta agaatctgta aatatgtaca aacaaatcac   4500

agtactgctt tatgttagaa ggcatatgat gttgtactgt atgtaagcaa taatacatag   4560

cagtgctaac tttacaagta gcatcaggaa agttctaaaa acatttcaga gttattaatt   4620

atccttattt catttaataa tgattatctt taatcagttt ttataagcaa attccattgt   4680

tcctcctatt ggaacgtaac actgtttaca cagcataatt gaagttgcag gggagacagg   4740

ctaaatctga cttcatctgt actcactttc actaagcatt gaatggcctt accactcttc   4800

tgcaagatgg aggaagaccg caaaacttag tgcccatcac actgaaggaa gggatgtggt   4860

tttttttcct gcttctgtac tgctacctaa ctttgtgatt tgctttggat tttaatattt   4920

gtttctgttt tagattcaag cccgtaagtt ttgaggtgac ttcagctcca ttgtgaaata   4980

gatagttctc ttcatatttc ataactacat ttcaataatt ctaaactttc tacattgatt   5040

tttagatact tatttttcaa gcttggtttc tcagctgatc agatgaattt attcaacttc   5100

aatacaaaga aagacaaacc tattatagtt tcaagtgagt agatattata ctgtacagga   5160

cagctatttg aacacacaca tcactgcttt agaaataaaa ccgccaattt ataaatgtat   5220

atgacctaca ttttatagga aaaaatgttt ttaaatgcta gtcatttata taatgtgctt   5280

tgaaggattt gctagtccac ttctgtcact ttttagtaca ctggtatctt ttatatgtaa   5340

tgtatgcttt ttattattgt agcaaagcat ttcagtagaa agaattttgc aacaatatgg   5400

gggaaatttt tcattgttgg atttgaatta tactggattt tatctgtgta gtcttacttg   5460

tctttatttt aatgctgtct gaagggaact tggtatccaa ataaagcagg taacctcatt   5520

ttacttcaag ggcatactgt gtagtgctga atttaatctg aaaatctgat gattttgaaa   5580

agaaaaacaa gtttataaac attgtacaga agaaattaaa tgtgtgtgat ggaaatcctg   5640

atggtggagc acgttgaatt ttctgatata tagtgttatt ttcctgggat cccctatgcc   5700

ttctttgtat ttcaactaat aaaggaaaaa ccctgtcatt aaaactggta agataatagg   5760

atattctgat tatacagtat tactattcct atcccatttt ctgacctttt ctcaatcact   5820

gtaaattttt attttctatt tcctattgat aattaaatat gtacataata tagacactgt   5880

tgtatagaac taaatgaatt gggttgctat gcttgagtgg gtagtgaaat ggaaatattt   5940

gatgaatact gagagttcct aaaatgctag agcaaatttc cgagggaaag gggggcatcg   6000

tgtgtcttgg gaaggttgca gcaggttgtt tcttcaactc cctaagaaat cattgggaag   6060

gactcaactg caaactcggg atcagataca aaatgggtct ttccttcccc tctcccccaa   6120

aaaataggag cactaaattt taaaatctac tcaggtgaca gttgctttgc aatgaaactt   6180

atcacattga aattttcagt gttaaataaa aagagatttg tgatattttt aaatataaac   6240

ttttacatca gtagtcagca gcctgacaat tgaaatttgg taagtcgata tattttaaaa   6300

tattttgctc tccaaataga attgttttta aacaattggg aggttttttg tttctttaaa   6360

tatgttttaa ttgtcattgt aaaaacaaaa tcttgcttga ccctatatta tgccatgaat   6420

gaattgctga gcctttataa tacagtgaca gcttgtttca tgcatagtca tggaacatag   6480

agatgttctt taaactgacc tattgataag aggtttaatg agtttcacgg ctttcaacac   6540

tattgtcata tagttatctt tgccatttgg agtttataaa accattttat gtattgtgat   6600

actaaaggaa gttgttttgc tttactttaa attgaattat tagactaata tttgcaaatt   6660

ctgcatttta aatgtggaca ctggctgttt gaaaaataaa atatagaata cagttttatg   6720

gataattttc gagctgaatt tttcacaata ttctgaacca aataacgaat ggtaaatatg   6780

caaaaatcat ggtgcataga tataaccgta aagagaaaag aatttctgtg tggaattaac   6840

agttacacaa attgggtaac aattatcagg gcctttatta tagctttatg tggaatgtta   6900

ttctaaaatg caagagtcaa atgttactgt cattgaatat tttagacttg aaacgtgttt   6960

atcatagagc gaagaaaata tgtgttcttt tctttacaga taagactctg ttaacccact   7020

gtcagcatac gtgggatttc ttttcttttt tctttcatta gtggagattt gttttcatcc   7080

atctaccacc ttgccagtac cctagcttgt gaccagcggg atgcattgta agaaagttgt   7140

ctgtggttag gagtgcagtc tgggtccatg gaacaaattt aaactaattg gccctcgcaa   7200

tgatcagtcc taggaccctg gccttattat tagcatggtg ctttaaccaa ttgtacataa   7260

taataccact gatagtctac taatgcattt cctagatccc agtttttctt gaatgattag   7320

gaatggtggg gagaggggag gggagatatt ctacatgata cttctccaat cttctaaaga   7380

ttataagaaa aaataaaaaa ttgaagtcac ttgaattaat gtgttgtcat tgagtcttac   7440

tcgacaattt atcatgcaca aagtgattat gaagattttc ctgattatat gtttggattg   7500

aatttaaaaa tttttttttt cag                                           7523


<210>  1735
<211>  144
<212>  PRT
<213>  Homo sapiens

<400>  1735


Met Lys Gly Glu Lys Pro Phe Gln Cys Ser Gln Cys Asp Met Arg Phe 
1               5                   10                  15      


Ile Gln Lys Tyr Leu Leu Gln Arg His Glu Lys Ile His Thr Gly Glu 
            20                  25                  30          


Lys Pro Phe Arg Cys Asp Glu Cys Gly Asp Glu Thr Asn His Ala Ser 
        35                  40                  45              


Ala Thr Ser Thr Gln Asp Phe Leu Asp Gln Val Thr Ser Gln Lys Lys 
    50                  55                  60                  


Ala Glu Ala Gln Pro Val His Gln Ala Tyr Gln Met Ser Ser Phe Glu 
65                  70                  75                  80  


Gln Pro Phe Arg Ala Pro Tyr His Gly Ser Arg Ala Gly Ile Ala Thr 
                85                  90                  95      


Gln Phe Ser Thr Ala Asn Gly Gln Val Asn Leu Arg Gly Pro Gly Thr 
            100                 105                 110         


Ser Ala Glu Phe Ser Glu Phe Pro Leu Val Asn Val Asn Asp Asn Arg 
        115                 120                 125             


Ala Gly Met Thr Ser Ser Pro Asp Ala Thr Thr Gly Gln Thr Phe Gly 
    130                 135                 140                 

<210>  1736
<211>  9651
<212>  DNA
<213>  Homo sapiens

<400>  1736
ggcgaccgcg gcggcgctct agctgcggca tgtctgcgtc tctactgctc tgggaggagg     60

aagagaagga ggaagaggag gaggaggagg agggggagga agaggagaaa ggcgcagggg    120

tgggagctgt tgccgaagct gccacagcaa aagttctccc ccctcccccc ttcccctcct    180

ctcaaggccc ctagaaaggt tggagctgcc gccgcctgca gtcggtgacc gcgcgactcg    240

gcgcccgccc gcggatagag ggaggaatca gcagcttgga aattcaagca cgtgatctgg    300

cgggatgggc gtttgcctaa cgtatttaat ggaggaatcg gatggcataa gtgattaagg    360

tggtattgag gatttctgaa gcctatgaaa ggtagaaact caaccatgat ttctttttca    420

actctacagc attcctttcc ttgaagtctt cgtttttacc ttagtctcgg gcagttatac    480

ttaagcatga acattgacga caaactggaa ggattgtttc ttaaatgtgg cggcatagac    540

gaaatgcagt cttccaggac aatggttgta atgggtggag tgtctggcca gtctactgtg    600

tctggagagc tacaggattc agtacttcaa gatcgaagta tgcctcacca ggagatcctt    660

gctgcagatg aagtgttaca agaaagtgaa atgagacaac aggatatgat atcacatgat    720

gaactcatgg tccatgagga gacagtgaaa aatgatgaag agcagatgga aacacatgaa    780

agacttcctc aaggactaca gtatgcactt aatgtcccta taagcgtaaa gcaggaaatt    840

acttttactg atgtatctga gcaactgatg agagacaaaa aacaaatcag agagccagta    900

gacttacaga aaaagaagaa gcggaaacaa cgttctcccg caaaaatcct tacaataaat    960

gaggatggat cacttggttt gaaaacccct aaatctcacg tttgtgagca ctgcaatgct   1020

gcctttagaa cgaactatca cttacagaga catgtcttca ttcatacagg tgaaaaacca   1080

tttcaatgta gtcaatgtga catgcgtttc atacagaagt acctgcttca gagacatgag   1140

aagattcata ctggtgaaaa accatttcgc tgtgatgaat gtggtatgag attcatacaa   1200

aaatatcata tggaaaggca taagagaact catagtggag aaaaacctta ccagtgtgaa   1260

tactgtttac agtatttttc cagaacagat cgtgtattga aacataaacg tatgtgccat   1320

gaaaatcatg acaaaaaact aaatagatgt gccatcaaag gtggccttct gacatctgag   1380

gaagattctg gcttttctac atcaccaaaa gacaactcac tgccaaaaaa gaaaaggcag   1440

aaaacggaga aaaaatcatc tggaatggac aaagagagtg ctttggacaa atctgacctg   1500

aaaaaagaca aaaatgatta cttgcctctt tattcttcaa gtactaaagt aaaagatgag   1560

tatatggttg cagaatatgc tgttgaaatg ccacattcgt cagttggggg ctcgcattta   1620

gaagatgcgt caggagaaat acacccacct aagttagttc tcaaaaaaat taatagtaag   1680

agaagtctga aacagccact ggagcaaaat caaacaattt cacctttatc cacatatgaa   1740

gagagcaaag tttcaaagta tgcttttgaa cttgtggata aacaggcttt actggactca   1800

gaaggcaatg ctgacattga tcaggttgat aatttgcagg aggggcccag taaacctgtg   1860

catagtagta ctaattatga tgatgccatg cagtttttga agaagaagcg gtatcttcaa   1920

gcagcaagta acaacagcag ggaatatgcg ctgaatgtgg gtaccatagc ttctcagcct   1980

tctgtaacac aagcagctgt ggcaagtgtc attgatgaaa gtaccacggc atccatatta   2040

gagtcacagg cactgaatgt ggagattaag agtaatcatg acaaaaatgt tattccagat   2100

gaggtactgc agactctgtt ggatcattat tcccacaaag ctaatggaca gcatgagata   2160

tccttcagtg ttgcagatac tgaagtgact tctagcatat caataaattc ttcagaagta   2220

ccagaggtca ccccgtcaga gaatgttgga tcaagctccc aagcatcctc atcagataaa   2280

gccaacatgt tgcaggaata ctccaagttt ctgcagcagg ctttggacag aactagccaa   2340

aatgatgcct atttgaatag cccgagcctt aactttgtga ctgataacca gaccctccca   2400

aatcagccag cattctcttc catagacaag caggtctatg ccaccatgcc catcaatagc   2460

tttcgatcag gaatgaattc tccactaaga acaactccag ataagtccca ctttggacta   2520

atagttggtg attcacagca ctcatttccc ttttcaggtg atgagacaaa ccatgcttct   2580

gccacatcaa cacaggactt tctggatcaa gtgacttctc agaagaaagc tgaggcccag   2640

cctgtccacc aagcttacca aatgagctcc tttgaacagc ccttccgtgc tccctatcat   2700

ggatcaagag ctggaatagc tactcaattt agcactgcca atggacaggt gaaccttcgg   2760

ggaccaggga caagtgctga attttcagaa tttcccttgg tgaatgtaaa tgataataga   2820

gctgggatga catcttcacc tgatgccaca actggccaga cttttggcta aaaaaaaaaa   2880

aaaagtgtaa ataatactgg cactttagaa cagattaatc aagagtgggg ttactctgtg   2940

taaatggagt gctgtacaga tttaagagca atgcgtaata acaagttaag ctgatatgaa   3000

tagcaagata atccaataac tgcatttcgt ttggttagtc agcattcttt gaactgcctt   3060

acatgttgtc acctttatag aagcaatgca ttacttgttt tagatcagaa acttgctatt   3120

ccacccacac caagttaaaa aggaaaaaaa aaagactttc gcacaattgt ttcctaactg   3180

ataacattgt acattcttag gagattagta attgtgtgaa atttactcat actgtttcta   3240

agtttttcag catagtcatt gcacttcagc agggaatctg agtatacttt acagacagag   3300

tgaacttaaa agtttaatgt caagagatta tggcttaaat aaattagtgt gtcctatagg   3360

gggaaaaaaa ccaagaaacc accttttaaa aagaatgata tgccatatac ccttgatttt   3420

cattttgcat tatattgacg tgtttttttg aaggaaaaaa agtaataaaa atctgatagt   3480

ctaagactcc actatttaaa agcctaatta ctttaaaaat atgcatactt tcagaacttt   3540

taccaaaaca cacaactgtt gaagcagtca cttctctatg gaagtatgca tattggtgtc   3600

agtttctttg tacagttgta cttagatatt ttttatgatt tttcatgtgc aggtatcaag   3660

gttttgaagt tttagtaaaa gaaattctgt agattacatt cccaagaaca taatgcttac   3720

acaaaatgta tattccacgt tttaaagctt aattgtattt tactttacat atacacttca   3780

gttaacatag agcacttaga atctatttgg tatttttgat ttctcaaagt aaaaaaaaaa   3840

ttagattttt aggtttgata tggttgtgtc ataatcatct cgtaattgac aattttaact   3900

tttggcaata aaaggaaatt gggatatctt tggaactgta aaacctggtt taatcttttt   3960

ctttctagac tcttgataga ttggataatt aaacagtatc cagagaaact aaagaaatgg   4020

gcattttaat tgcatatttt atcttgagtt actttttaat gaacactgct cattacaact   4080

ttacaaacca aaagtgttta ctaattccag taactaccat ttctttttca gctagatgag   4140

tgatcggaaa atttttgttg catttcaaaa tctaaataaa ctacagactt tatccttata   4200

ccatgaatgt ttttttttaa tactctgtct taaaataata cagcatggta caataaatag   4260

tgcttttatg tatatataca cacacacact tttctgaaga atgatggttt gagttatgcg   4320

ttgggcagtt ttgatttttg gaagttatat tagttattga ctctttgtta caactttttc   4380

atttttacat tttaaatttt ctgccatcgt tgtcacaatg cacatcctga tatagcacca   4440

gtgaaaatct aaaattaata cccttggaaa atgaaaatat tcttaatttc cattttgact   4500

cttatactgg ccctatagct ctgcagtctt tgtttcaata tagaatatgt tatccattta   4560

aattattttt tcttttattt aatgttatcc caagactgtt ctcataaaga aagggaagaa   4620

ataactatcc acccttaaca tccttcattt attttgaata tattggtgtt tttatgataa   4680

ggaatataaa ttatatttaa tgtggtttcc tgtatacttt ggttattaag ttttgcttga   4740

aatagtagtt ttcccgtttg acagctttct ttgctgccaa agttttcaag aatttaagac   4800

ttctttgaag taaatattta agttctgcca ttattgactc ttaagattgt gtgtgttgtg   4860

ttgtgcatta cataattaca aaaaggcttc attcaggtga tacgttaaaa atggaactgt   4920

gctcacccta aataggcatt ggtatttttc tcttttggtg agagtaggca tttatttctt   4980

gagttgtttt ggagcctgat caaaaatttt gttcatggag aacttgatgc aattttgata   5040

cagtggagag gtttttttcg gttgttttaa catcaccagc atagttttta gaatgtgact   5100

cttgctgagc atttagggtg agcttgggaa ggaaggcctt tgaaaatggt agttatgcaa   5160

gcagactttc aggtgttgca ttcctgtttt caacacattt ctttaaatct acataatggc   5220

agacttttct accaggttat aagcagtttt tagataagtg atactcagcc agcataactt   5280

attgacttac catttacgta tagtcatcac tctcttactg tgaaattcca aatgcctacc   5340

agagttacct tgttctatca taatatgaca aacatctcaa cagttttgga tttccccact   5400

ttggttcaga aggttattta atttctatct gggcattaat ggagaaaata agtagccttg   5460

tgtgctgctt cagattgaaa catggaggat atgagatatt cttctgcaat tcatgtttct   5520

catttctcaa agtgagcaca ttgttctata aaaacatgct ggtacaccct taaacttttg   5580

atcaatctga gtgaggtgtg cttttcctct tgggacctac tcacgtttga agattggaaa   5640

catcacgtta ggcgaggcag tatctcttga acatcttcta aagggttttt taaaacctta   5700

ttctcacata tttcatttgt cttgaatatt taagtggctc ttaaacgttt tgggtctaca   5760

tgcaaatgtg gtacttaaca aggtaggaat ccatcttctt agctctggct gagggtgcca   5820

gccatcggtc aggtcatttt tatctcaaga ggcagaaggc agttatgtca agaattgtgc   5880

tcagggcagg atttcgtttc cacagaggag agacacttgc agagtgccag ctaggttaga   5940

tcttttgccg cttctttcat ttgattaatt tgggttttta aagggctgtt taaaaaaaaa   6000

aaaaaaaggc cgggaaactt taaaagtagg cattactgta gtactgcatt tcttagaaca   6060

ttttaaacta gaactcattt ttttttcaca gtatatttac ttgaagaagc actataataa   6120

tcattgagaa gtattttgag tctgaaattt aatttaattt tccgtttcaa attgctttat   6180

ttcagggaaa taattttcca gttgttttgc tatattctgc aaataaaaac cgtgtttcct   6240

tttttcactt aaactttggt aggaaacaaa ctaaagcaga caaacatttc ttgttatgtt   6300

tgttgctttc tttaatccaa tggataaaaa agtaaaaccc tgtaaacatt attttatttt   6360

tttatgcaat accatgctgt aaatatggtt catcaaataa ggatgtacct atgattgaat   6420

ctttaattct gcacagttag agtttatata taaacgtgtc ttgacaatca aggactttta   6480

tgtgagtctt cctttatgat gtttattaat gttatgcatt ccatttgttt tgaagtgagt   6540

accaatgtgc taatttgtat tgtctgaaag tatgtaatgt ttttacagct tgtttttaag   6600

aatctgtaaa tatgtacaaa caaatcacag tactgcttta tgttagaagg catatgatgt   6660

tgtactgtat gtaagcaata atacatagca gtgctaactt tacaagtagc atcaggaaag   6720

ttctaaaaac atttcagagt tattaattat ccttatttca tttaataatg attatcttta   6780

atcagttttt ataagcaaat tccattgttc ctcctattgg aacgtaacac tgtttacaca   6840

gcataattga agttgcaggg gagacaggct aaatctgact tcatctgtac tcactttcac   6900

taagcattga atggccttac cactcttctg caagatggag gaagaccgca aaacttagtg   6960

cccatcacac tgaaggaagg gatgtggttt tttttcctgc ttctgtactg ctacctaact   7020

ttgtgatttg ctttggattt taatatttgt ttctgtttta gattcaagcc cgtaagtttt   7080

gaggtgactt cagctccatt gtgaaataga tagttctctt catatttcat aactacattt   7140

caataattct aaactttcta cattgatttt tagatactta tttttcaagc ttggtttctc   7200

agctgatcag atgaatttat tcaacttcaa tacaaagaaa gacaaaccta ttatagtttc   7260

aagtgagtag atattatact gtacaggaca gctatttgaa cacacacatc actgctttag   7320

aaataaaacc gccaatttat aaatgtatat gacctacatt ttataggaaa aaatgttttt   7380

aaatgctagt catttatata atgtgctttg aaggatttgc tagtccactt ctgtcacttt   7440

ttagtacact ggtatctttt atatgtaatg tatgcttttt attattgtag caaagcattt   7500

cagtagaaag aattttgcaa caatatgggg gaaatttttc attgttggat ttgaattata   7560

ctggatttta tctgtgtagt cttacttgtc tttattttaa tgctgtctga agggaacttg   7620

gtatccaaat aaagcaggta acctcatttt acttcaaggg catactgtgt agtgctgaat   7680

ttaatctgaa aatctgatga ttttgaaaag aaaaacaagt ttataaacat tgtacagaag   7740

aaattaaatg tgtgtgatgg aaatcctgat ggtggagcac gttgaatttt ctgatatata   7800

gtgttatttt cctgggatcc cctatgcctt ctttgtattt caactaataa aggaaaaacc   7860

ctgtcattaa aactggtaag ataataggat attctgatta tacagtatta ctattcctat   7920

cccattttct gaccttttct caatcactgt aaatttttat tttctatttc ctattgataa   7980

ttaaatatgt acataatata gacactgttg tatagaacta aatgaattgg gttgctatgc   8040

ttgagtgggt agtgaaatgg aaatatttga tgaatactga gagttcctaa aatgctagag   8100

caaatttccg agggaaaggg gggcatcgtg tgtcttggga aggttgcagc aggttgtttc   8160

ttcaactccc taagaaatca ttgggaagga ctcaactgca aactcgggat cagatacaaa   8220

atgggtcttt ccttcccctc tcccccaaaa aataggagca ctaaatttta aaatctactc   8280

aggtgacagt tgctttgcaa tgaaacttat cacattgaaa ttttcagtgt taaataaaaa   8340

gagatttgtg atatttttaa atataaactt ttacatcagt agtcagcagc ctgacaattg   8400

aaatttggta agtcgatata ttttaaaata ttttgctctc caaatagaat tgtttttaaa   8460

caattgggag gttttttgtt tctttaaata tgttttaatt gtcattgtaa aaacaaaatc   8520

ttgcttgacc ctatattatg ccatgaatga attgctgagc ctttataata cagtgacagc   8580

ttgtttcatg catagtcatg gaacatagag atgttcttta aactgaccta ttgataagag   8640

gtttaatgag tttcacggct ttcaacacta ttgtcatata gttatctttg ccatttggag   8700

tttataaaac cattttatgt attgtgatac taaaggaagt tgttttgctt tactttaaat   8760

tgaattatta gactaatatt tgcaaattct gcattttaaa tgtggacact ggctgtttga   8820

aaaataaaat atagaataca gttttatgga taattttcga gctgaatttt tcacaatatt   8880

ctgaaccaaa taacgaatgg taaatatgca aaaatcatgg tgcatagata taaccgtaaa   8940

gagaaaagaa tttctgtgtg gaattaacag ttacacaaat tgggtaacaa ttatcagggc   9000

ctttattata gctttatgtg gaatgttatt ctaaaatgca agagtcaaat gttactgtca   9060

ttgaatattt tagacttgaa acgtgtttat catagagcga agaaaatatg tgttcttttc   9120

tttacagata agactctgtt aacccactgt cagcatacgt gggatttctt ttcttttttc   9180

tttcattagt ggagatttgt tttcatccat ctaccacctt gccagtaccc tagcttgtga   9240

ccagcgggat gcattgtaag aaagttgtct gtggttagga gtgcagtctg ggtccatgga   9300

acaaatttaa actaattggc cctcgcaatg atcagtccta ggaccctggc cttattatta   9360

gcatggtgct ttaaccaatt gtacataata ataccactga tagtctacta atgcatttcc   9420

tagatcccag tttttcttga atgattagga atggtgggga gaggggaggg gagatattct   9480

acatgatact tctccaatct tctaaagatt ataagaaaaa ataaaaaatt gaagtcactt   9540

gaattaatgt gttgtcattg agtcttactc gacaatttat catgcacaaa gtgattatga   9600

agattttcct gattatatgt ttggattgaa tttaaaaatt ttttttttca g            9651


<210>  1737
<211>  794
<212>  PRT
<213>  Homo sapiens

<400>  1737


Met Asn Ile Asp Asp Lys Leu Glu Gly Leu Phe Leu Lys Cys Gly Gly 
1               5                   10                  15      


Ile Asp Glu Met Gln Ser Ser Arg Thr Met Val Val Met Gly Gly Val 
            20                  25                  30          


Ser Gly Gln Ser Thr Val Ser Gly Glu Leu Gln Asp Ser Val Leu Gln 
        35                  40                  45              


Asp Arg Ser Met Pro His Gln Glu Ile Leu Ala Ala Asp Glu Val Leu 
    50                  55                  60                  


Gln Glu Ser Glu Met Arg Gln Gln Asp Met Ile Ser His Asp Glu Leu 
65                  70                  75                  80  


Met Val His Glu Glu Thr Val Lys Asn Asp Glu Glu Gln Met Glu Thr 
                85                  90                  95      


His Glu Arg Leu Pro Gln Gly Leu Gln Tyr Ala Leu Asn Val Pro Ile 
            100                 105                 110         


Ser Val Lys Gln Glu Ile Thr Phe Thr Asp Val Ser Glu Gln Leu Met 
        115                 120                 125             


Arg Asp Lys Lys Gln Ile Arg Glu Pro Val Asp Leu Gln Lys Lys Lys 
    130                 135                 140                 


Lys Arg Lys Gln Arg Ser Pro Ala Lys Ile Leu Thr Ile Asn Glu Asp 
145                 150                 155                 160 


Gly Ser Leu Gly Leu Lys Thr Pro Lys Ser His Val Cys Glu His Cys 
                165                 170                 175     


Asn Ala Ala Phe Arg Thr Asn Tyr His Leu Gln Arg His Val Phe Ile 
            180                 185                 190         


His Thr Gly Glu Lys Pro Phe Gln Cys Ser Gln Cys Asp Met Arg Phe 
        195                 200                 205             


Ile Gln Lys Tyr Leu Leu Gln Arg His Glu Lys Ile His Thr Gly Glu 
    210                 215                 220                 


Lys Pro Phe Arg Cys Asp Glu Cys Gly Met Arg Phe Ile Gln Lys Tyr 
225                 230                 235                 240 


His Met Glu Arg His Lys Arg Thr His Ser Gly Glu Lys Pro Tyr Gln 
                245                 250                 255     


Cys Glu Tyr Cys Leu Gln Tyr Phe Ser Arg Thr Asp Arg Val Leu Lys 
            260                 265                 270         


His Lys Arg Met Cys His Glu Asn His Asp Lys Lys Leu Asn Arg Cys 
        275                 280                 285             


Ala Ile Lys Gly Gly Leu Leu Thr Ser Glu Glu Asp Ser Gly Phe Ser 
    290                 295                 300                 


Thr Ser Pro Lys Asp Asn Ser Leu Pro Lys Lys Lys Arg Gln Lys Thr 
305                 310                 315                 320 


Glu Lys Lys Ser Ser Gly Met Asp Lys Glu Ser Ala Leu Asp Lys Ser 
                325                 330                 335     


Asp Leu Lys Lys Asp Lys Asn Asp Tyr Leu Pro Leu Tyr Ser Ser Ser 
            340                 345                 350         


Thr Lys Val Lys Asp Glu Tyr Met Val Ala Glu Tyr Ala Val Glu Met 
        355                 360                 365             


Pro His Ser Ser Val Gly Gly Ser His Leu Glu Asp Ala Ser Gly Glu 
    370                 375                 380                 


Ile His Pro Pro Lys Leu Val Leu Lys Lys Ile Asn Ser Lys Arg Ser 
385                 390                 395                 400 


Leu Lys Gln Pro Leu Glu Gln Asn Gln Thr Ile Ser Pro Leu Ser Thr 
                405                 410                 415     


Tyr Glu Glu Ser Lys Val Ser Lys Tyr Ala Phe Glu Leu Val Asp Lys 
            420                 425                 430         


Gln Ala Leu Leu Asp Ser Glu Gly Asn Ala Asp Ile Asp Gln Val Asp 
        435                 440                 445             


Asn Leu Gln Glu Gly Pro Ser Lys Pro Val His Ser Ser Thr Asn Tyr 
    450                 455                 460                 


Asp Asp Ala Met Gln Phe Leu Lys Lys Lys Arg Tyr Leu Gln Ala Ala 
465                 470                 475                 480 


Ser Asn Asn Ser Arg Glu Tyr Ala Leu Asn Val Gly Thr Ile Ala Ser 
                485                 490                 495     


Gln Pro Ser Val Thr Gln Ala Ala Val Ala Ser Val Ile Asp Glu Ser 
            500                 505                 510         


Thr Thr Ala Ser Ile Leu Glu Ser Gln Ala Leu Asn Val Glu Ile Lys 
        515                 520                 525             


Ser Asn His Asp Lys Asn Val Ile Pro Asp Glu Val Leu Gln Thr Leu 
    530                 535                 540                 


Leu Asp His Tyr Ser His Lys Ala Asn Gly Gln His Glu Ile Ser Phe 
545                 550                 555                 560 


Ser Val Ala Asp Thr Glu Val Thr Ser Ser Ile Ser Ile Asn Ser Ser 
                565                 570                 575     


Glu Val Pro Glu Val Thr Pro Ser Glu Asn Val Gly Ser Ser Ser Gln 
            580                 585                 590         


Ala Ser Ser Ser Asp Lys Ala Asn Met Leu Gln Glu Tyr Ser Lys Phe 
        595                 600                 605             


Leu Gln Gln Ala Leu Asp Arg Thr Ser Gln Asn Asp Ala Tyr Leu Asn 
    610                 615                 620                 


Ser Pro Ser Leu Asn Phe Val Thr Asp Asn Gln Thr Leu Pro Asn Gln 
625                 630                 635                 640 


Pro Ala Phe Ser Ser Ile Asp Lys Gln Val Tyr Ala Thr Met Pro Ile 
                645                 650                 655     


Asn Ser Phe Arg Ser Gly Met Asn Ser Pro Leu Arg Thr Thr Pro Asp 
            660                 665                 670         


Lys Ser His Phe Gly Leu Ile Val Gly Asp Ser Gln His Ser Phe Pro 
        675                 680                 685             


Phe Ser Gly Asp Glu Thr Asn His Ala Ser Ala Thr Ser Thr Gln Asp 
    690                 695                 700                 


Phe Leu Asp Gln Val Thr Ser Gln Lys Lys Ala Glu Ala Gln Pro Val 
705                 710                 715                 720 


His Gln Ala Tyr Gln Met Ser Ser Phe Glu Gln Pro Phe Arg Ala Pro 
                725                 730                 735     


Tyr His Gly Ser Arg Ala Gly Ile Ala Thr Gln Phe Ser Thr Ala Asn 
            740                 745                 750         


Gly Gln Val Asn Leu Arg Gly Pro Gly Thr Ser Ala Glu Phe Ser Glu 
        755                 760                 765             


Phe Pro Leu Val Asn Val Asn Asp Asn Arg Ala Gly Met Thr Ser Ser 
    770                 775                 780                 


Pro Asp Ala Thr Thr Gly Gln Thr Phe Gly 
785                 790                 

<210>  1738
<211>  9768
<212>  DNA
<213>  Homo sapiens

<400>  1738
ggcgaccgcg gcggcgctct agctgcggca tgtctgcgtc tctactgctc tgggaggagg     60

aagagaagga ggaagaggag gaggaggagg agggggagga agaggagaaa ggcgcagggg    120

tgggagctgt tgccgaagct gccacagcaa aagttctccc ccctcccccc ttcccctcct    180

ctcaaggccc ctagaaaggt tggagctgcc gccgcctgca gtcggtgacc gcgcgactcg    240

gcgcccgccc gcggatagag ggaggaatca gcagcttgga aattcaagca cgtgatctgg    300

cgggatgggc gtttgcctaa cgtatttaat ggaggaatcg gatggcataa gtgattaagg    360

tggtattgag gatttctgaa gcctatgaaa ggtagaaact caaccatgat ttctttttca    420

actctacagc attcctttcc ttgaagtctt cgtttttacc ttagtctcgg ggtcttattc    480

tgtcacctag gtggagtgca gtagtacagt cacagctcac tgcagcccca acatcctggg    540

ctcaagccat cctcctgcct cagcctccca agtagctggg accacaggca gttatactta    600

agcatgaaca ttgacgacaa actggaagga ttgtttctta aatgtggcgg catagacgaa    660

atgcagtctt ccaggacaat ggttgtaatg ggtggagtgt ctggccagtc tactgtgtct    720

ggagagctac aggattcagt acttcaagat cgaagtatgc ctcaccagga gatccttgct    780

gcagatgaag tgttacaaga aagtgaaatg agacaacagg atatgatatc acatgatgaa    840

ctcatggtcc atgaggagac agtgaaaaat gatgaagagc agatggaaac acatgaaaga    900

cttcctcaag gactacagta tgcacttaat gtccctataa gcgtaaagca ggaaattact    960

tttactgatg tatctgagca actgatgaga gacaaaaaac aaatcagaga gccagtagac   1020

ttacagaaaa agaagaagcg gaaacaacgt tctcccgcaa aaatccttac aataaatgag   1080

gatggatcac ttggtttgaa aacccctaaa tctcacgttt gtgagcactg caatgctgcc   1140

tttagaacga actatcactt acagagacat gtcttcattc atacaggtga aaaaccattt   1200

caatgtagtc aatgtgacat gcgtttcata cagaagtacc tgcttcagag acatgagaag   1260

attcatactg gtgaaaaacc atttcgctgt gatgaatgtg gtatgagatt catacaaaaa   1320

tatcatatgg aaaggcataa gagaactcat agtggagaaa aaccttacca gtgtgaatac   1380

tgtttacagt atttttccag aacagatcgt gtattgaaac ataaacgtat gtgccatgaa   1440

aatcatgaca aaaaactaaa tagatgtgcc atcaaaggtg gccttctgac atctgaggaa   1500

gattctggct tttctacatc accaaaagac aactcactgc caaaaaagaa aaggcagaaa   1560

acggagaaaa aatcatctgg aatggacaaa gagagtgctt tggacaaatc tgacctgaaa   1620

aaagacaaaa atgattactt gcctctttat tcttcaagta ctaaagtaaa agatgagtat   1680

atggttgcag aatatgctgt tgaaatgcca cattcgtcag ttgggggctc gcatttagaa   1740

gatgcgtcag gagaaataca cccacctaag ttagttctca aaaaaattaa tagtaagaga   1800

agtctgaaac agccactgga gcaaaatcaa acaatttcac ctttatccac atatgaagag   1860

agcaaagttt caaagtatgc ttttgaactt gtggataaac aggctttact ggactcagaa   1920

ggcaatgctg acattgatca ggttgataat ttgcaggagg ggcccagtaa acctgtgcat   1980

agtagtacta attatgatga tgccatgcag tttttgaaga agaagcggta tcttcaagca   2040

gcaagtaaca acagcaggga atatgcgctg aatgtgggta ccatagcttc tcagccttct   2100

gtaacacaag cagctgtggc aagtgtcatt gatgaaagta ccacggcatc catattagag   2160

tcacaggcac tgaatgtgga gattaagagt aatcatgaca aaaatgttat tccagatgag   2220

gtactgcaga ctctgttgga tcattattcc cacaaagcta atggacagca tgagatatcc   2280

ttcagtgttg cagatactga agtgacttct agcatatcaa taaattcttc agaagtacca   2340

gaggtcaccc cgtcagagaa tgttggatca agctcccaag catcctcatc agataaagcc   2400

aacatgttgc aggaatactc caagtttctg cagcaggctt tggacagaac tagccaaaat   2460

gatgcctatt tgaatagccc gagccttaac tttgtgactg ataaccagac cctcccaaat   2520

cagccagcat tctcttccat agacaagcag gtctatgcca ccatgcccat caatagcttt   2580

cgatcaggaa tgaattctcc actaagaaca actccagata agtcccactt tggactaata   2640

gttggtgatt cacagcactc atttcccttt tcaggtgatg agacaaacca tgcttctgcc   2700

acatcaacac aggactttct ggatcaagtg acttctcaga agaaagctga ggcccagcct   2760

gtccaccaag cttaccaaat gagctccttt gaacagccct tccgtgctcc ctatcatgga   2820

tcaagagctg gaatagctac tcaatttagc actgccaatg gacaggtgaa ccttcgggga   2880

ccagggacaa gtgctgaatt ttcagaattt cccttggtga atgtaaatga taatagagct   2940

gggatgacat cttcacctga tgccacaact ggccagactt ttggctaaaa aaaaaaaaaa   3000

agtgtaaata atactggcac tttagaacag attaatcaag agtggggtta ctctgtgtaa   3060

atggagtgct gtacagattt aagagcaatg cgtaataaca agttaagctg atatgaatag   3120

caagataatc caataactgc atttcgtttg gttagtcagc attctttgaa ctgccttaca   3180

tgttgtcacc tttatagaag caatgcatta cttgttttag atcagaaact tgctattcca   3240

cccacaccaa gttaaaaagg aaaaaaaaaa gactttcgca caattgtttc ctaactgata   3300

acattgtaca ttcttaggag attagtaatt gtgtgaaatt tactcatact gtttctaagt   3360

ttttcagcat agtcattgca cttcagcagg gaatctgagt atactttaca gacagagtga   3420

acttaaaagt ttaatgtcaa gagattatgg cttaaataaa ttagtgtgtc ctataggggg   3480

aaaaaaacca agaaaccacc ttttaaaaag aatgatatgc catataccct tgattttcat   3540

tttgcattat attgacgtgt ttttttgaag gaaaaaaagt aataaaaatc tgatagtcta   3600

agactccact atttaaaagc ctaattactt taaaaatatg catactttca gaacttttac   3660

caaaacacac aactgttgaa gcagtcactt ctctatggaa gtatgcatat tggtgtcagt   3720

ttctttgtac agttgtactt agatattttt tatgattttt catgtgcagg tatcaaggtt   3780

ttgaagtttt agtaaaagaa attctgtaga ttacattccc aagaacataa tgcttacaca   3840

aaatgtatat tccacgtttt aaagcttaat tgtattttac tttacatata cacttcagtt   3900

aacatagagc acttagaatc tatttggtat ttttgatttc tcaaagtaaa aaaaaaatta   3960

gatttttagg tttgatatgg ttgtgtcata atcatctcgt aattgacaat tttaactttt   4020

ggcaataaaa ggaaattggg atatctttgg aactgtaaaa cctggtttaa tctttttctt   4080

tctagactct tgatagattg gataattaaa cagtatccag agaaactaaa gaaatgggca   4140

ttttaattgc atattttatc ttgagttact ttttaatgaa cactgctcat tacaacttta   4200

caaaccaaaa gtgtttacta attccagtaa ctaccatttc tttttcagct agatgagtga   4260

tcggaaaatt tttgttgcat ttcaaaatct aaataaacta cagactttat ccttatacca   4320

tgaatgtttt tttttaatac tctgtcttaa aataatacag catggtacaa taaatagtgc   4380

ttttatgtat atatacacac acacactttt ctgaagaatg atggtttgag ttatgcgttg   4440

ggcagttttg atttttggaa gttatattag ttattgactc tttgttacaa ctttttcatt   4500

tttacatttt aaattttctg ccatcgttgt cacaatgcac atcctgatat agcaccagtg   4560

aaaatctaaa attaataccc ttggaaaatg aaaatattct taatttccat tttgactctt   4620

atactggccc tatagctctg cagtctttgt ttcaatatag aatatgttat ccatttaaat   4680

tattttttct tttatttaat gttatcccaa gactgttctc ataaagaaag ggaagaaata   4740

actatccacc cttaacatcc ttcatttatt ttgaatatat tggtgttttt atgataagga   4800

atataaatta tatttaatgt ggtttcctgt atactttggt tattaagttt tgcttgaaat   4860

agtagttttc ccgtttgaca gctttctttg ctgccaaagt tttcaagaat ttaagacttc   4920

tttgaagtaa atatttaagt tctgccatta ttgactctta agattgtgtg tgttgtgttg   4980

tgcattacat aattacaaaa aggcttcatt caggtgatac gttaaaaatg gaactgtgct   5040

caccctaaat aggcattggt atttttctct tttggtgaga gtaggcattt atttcttgag   5100

ttgttttgga gcctgatcaa aaattttgtt catggagaac ttgatgcaat tttgatacag   5160

tggagaggtt tttttcggtt gttttaacat caccagcata gtttttagaa tgtgactctt   5220

gctgagcatt tagggtgagc ttgggaagga aggcctttga aaatggtagt tatgcaagca   5280

gactttcagg tgttgcattc ctgttttcaa cacatttctt taaatctaca taatggcaga   5340

cttttctacc aggttataag cagtttttag ataagtgata ctcagccagc ataacttatt   5400

gacttaccat ttacgtatag tcatcactct cttactgtga aattccaaat gcctaccaga   5460

gttaccttgt tctatcataa tatgacaaac atctcaacag ttttggattt ccccactttg   5520

gttcagaagg ttatttaatt tctatctggg cattaatgga gaaaataagt agccttgtgt   5580

gctgcttcag attgaaacat ggaggatatg agatattctt ctgcaattca tgtttctcat   5640

ttctcaaagt gagcacattg ttctataaaa acatgctggt acacccttaa acttttgatc   5700

aatctgagtg aggtgtgctt ttcctcttgg gacctactca cgtttgaaga ttggaaacat   5760

cacgttaggc gaggcagtat ctcttgaaca tcttctaaag ggttttttaa aaccttattc   5820

tcacatattt catttgtctt gaatatttaa gtggctctta aacgttttgg gtctacatgc   5880

aaatgtggta cttaacaagg taggaatcca tcttcttagc tctggctgag ggtgccagcc   5940

atcggtcagg tcatttttat ctcaagaggc agaaggcagt tatgtcaaga attgtgctca   6000

gggcaggatt tcgtttccac agaggagaga cacttgcaga gtgccagcta ggttagatct   6060

tttgccgctt ctttcatttg attaatttgg gtttttaaag ggctgtttaa aaaaaaaaaa   6120

aaaaggccgg gaaactttaa aagtaggcat tactgtagta ctgcatttct tagaacattt   6180

taaactagaa ctcatttttt tttcacagta tatttacttg aagaagcact ataataatca   6240

ttgagaagta ttttgagtct gaaatttaat ttaattttcc gtttcaaatt gctttatttc   6300

agggaaataa ttttccagtt gttttgctat attctgcaaa taaaaaccgt gtttcctttt   6360

ttcacttaaa ctttggtagg aaacaaacta aagcagacaa acatttcttg ttatgtttgt   6420

tgctttcttt aatccaatgg ataaaaaagt aaaaccctgt aaacattatt ttattttttt   6480

atgcaatacc atgctgtaaa tatggttcat caaataagga tgtacctatg attgaatctt   6540

taattctgca cagttagagt ttatatataa acgtgtcttg acaatcaagg acttttatgt   6600

gagtcttcct ttatgatgtt tattaatgtt atgcattcca tttgttttga agtgagtacc   6660

aatgtgctaa tttgtattgt ctgaaagtat gtaatgtttt tacagcttgt ttttaagaat   6720

ctgtaaatat gtacaaacaa atcacagtac tgctttatgt tagaaggcat atgatgttgt   6780

actgtatgta agcaataata catagcagtg ctaactttac aagtagcatc aggaaagttc   6840

taaaaacatt tcagagttat taattatcct tatttcattt aataatgatt atctttaatc   6900

agtttttata agcaaattcc attgttcctc ctattggaac gtaacactgt ttacacagca   6960

taattgaagt tgcaggggag acaggctaaa tctgacttca tctgtactca ctttcactaa   7020

gcattgaatg gccttaccac tcttctgcaa gatggaggaa gaccgcaaaa cttagtgccc   7080

atcacactga aggaagggat gtggtttttt ttcctgcttc tgtactgcta cctaactttg   7140

tgatttgctt tggattttaa tatttgtttc tgttttagat tcaagcccgt aagttttgag   7200

gtgacttcag ctccattgtg aaatagatag ttctcttcat atttcataac tacatttcaa   7260

taattctaaa ctttctacat tgatttttag atacttattt ttcaagcttg gtttctcagc   7320

tgatcagatg aatttattca acttcaatac aaagaaagac aaacctatta tagtttcaag   7380

tgagtagata ttatactgta caggacagct atttgaacac acacatcact gctttagaaa   7440

taaaaccgcc aatttataaa tgtatatgac ctacatttta taggaaaaaa tgtttttaaa   7500

tgctagtcat ttatataatg tgctttgaag gatttgctag tccacttctg tcacttttta   7560

gtacactggt atcttttata tgtaatgtat gctttttatt attgtagcaa agcatttcag   7620

tagaaagaat tttgcaacaa tatgggggaa atttttcatt gttggatttg aattatactg   7680

gattttatct gtgtagtctt acttgtcttt attttaatgc tgtctgaagg gaacttggta   7740

tccaaataaa gcaggtaacc tcattttact tcaagggcat actgtgtagt gctgaattta   7800

atctgaaaat ctgatgattt tgaaaagaaa aacaagttta taaacattgt acagaagaaa   7860

ttaaatgtgt gtgatggaaa tcctgatggt ggagcacgtt gaattttctg atatatagtg   7920

ttattttcct gggatcccct atgccttctt tgtatttcaa ctaataaagg aaaaaccctg   7980

tcattaaaac tggtaagata ataggatatt ctgattatac agtattacta ttcctatccc   8040

attttctgac cttttctcaa tcactgtaaa tttttatttt ctatttccta ttgataatta   8100

aatatgtaca taatatagac actgttgtat agaactaaat gaattgggtt gctatgcttg   8160

agtgggtagt gaaatggaaa tatttgatga atactgagag ttcctaaaat gctagagcaa   8220

atttccgagg gaaagggggg catcgtgtgt cttgggaagg ttgcagcagg ttgtttcttc   8280

aactccctaa gaaatcattg ggaaggactc aactgcaaac tcgggatcag atacaaaatg   8340

ggtctttcct tcccctctcc cccaaaaaat aggagcacta aattttaaaa tctactcagg   8400

tgacagttgc tttgcaatga aacttatcac attgaaattt tcagtgttaa ataaaaagag   8460

atttgtgata tttttaaata taaactttta catcagtagt cagcagcctg acaattgaaa   8520

tttggtaagt cgatatattt taaaatattt tgctctccaa atagaattgt ttttaaacaa   8580

ttgggaggtt ttttgtttct ttaaatatgt tttaattgtc attgtaaaaa caaaatcttg   8640

cttgacccta tattatgcca tgaatgaatt gctgagcctt tataatacag tgacagcttg   8700

tttcatgcat agtcatggaa catagagatg ttctttaaac tgacctattg ataagaggtt   8760

taatgagttt cacggctttc aacactattg tcatatagtt atctttgcca tttggagttt   8820

ataaaaccat tttatgtatt gtgatactaa aggaagttgt tttgctttac tttaaattga   8880

attattagac taatatttgc aaattctgca ttttaaatgt ggacactggc tgtttgaaaa   8940

ataaaatata gaatacagtt ttatggataa ttttcgagct gaatttttca caatattctg   9000

aaccaaataa cgaatggtaa atatgcaaaa atcatggtgc atagatataa ccgtaaagag   9060

aaaagaattt ctgtgtggaa ttaacagtta cacaaattgg gtaacaatta tcagggcctt   9120

tattatagct ttatgtggaa tgttattcta aaatgcaaga gtcaaatgtt actgtcattg   9180

aatattttag acttgaaacg tgtttatcat agagcgaaga aaatatgtgt tcttttcttt   9240

acagataaga ctctgttaac ccactgtcag catacgtggg atttcttttc ttttttcttt   9300

cattagtgga gatttgtttt catccatcta ccaccttgcc agtaccctag cttgtgacca   9360

gcgggatgca ttgtaagaaa gttgtctgtg gttaggagtg cagtctgggt ccatggaaca   9420

aatttaaact aattggccct cgcaatgatc agtcctagga ccctggcctt attattagca   9480

tggtgcttta accaattgta cataataata ccactgatag tctactaatg catttcctag   9540

atcccagttt ttcttgaatg attaggaatg gtggggagag gggaggggag atattctaca   9600

tgatacttct ccaatcttct aaagattata agaaaaaata aaaaattgaa gtcacttgaa   9660

ttaatgtgtt gtcattgagt cttactcgac aatttatcat gcacaaagtg attatgaaga   9720

ttttcctgat tatatgtttg gattgaattt aaaaattttt tttttcag                9768


<210>  1739
<211>  794
<212>  PRT
<213>  Homo sapiens

<400>  1739


Met Asn Ile Asp Asp Lys Leu Glu Gly Leu Phe Leu Lys Cys Gly Gly 
1               5                   10                  15      


Ile Asp Glu Met Gln Ser Ser Arg Thr Met Val Val Met Gly Gly Val 
            20                  25                  30          


Ser Gly Gln Ser Thr Val Ser Gly Glu Leu Gln Asp Ser Val Leu Gln 
        35                  40                  45              


Asp Arg Ser Met Pro His Gln Glu Ile Leu Ala Ala Asp Glu Val Leu 
    50                  55                  60                  


Gln Glu Ser Glu Met Arg Gln Gln Asp Met Ile Ser His Asp Glu Leu 
65                  70                  75                  80  


Met Val His Glu Glu Thr Val Lys Asn Asp Glu Glu Gln Met Glu Thr 
                85                  90                  95      


His Glu Arg Leu Pro Gln Gly Leu Gln Tyr Ala Leu Asn Val Pro Ile 
            100                 105                 110         


Ser Val Lys Gln Glu Ile Thr Phe Thr Asp Val Ser Glu Gln Leu Met 
        115                 120                 125             


Arg Asp Lys Lys Gln Ile Arg Glu Pro Val Asp Leu Gln Lys Lys Lys 
    130                 135                 140                 


Lys Arg Lys Gln Arg Ser Pro Ala Lys Ile Leu Thr Ile Asn Glu Asp 
145                 150                 155                 160 


Gly Ser Leu Gly Leu Lys Thr Pro Lys Ser His Val Cys Glu His Cys 
                165                 170                 175     


Asn Ala Ala Phe Arg Thr Asn Tyr His Leu Gln Arg His Val Phe Ile 
            180                 185                 190         


His Thr Gly Glu Lys Pro Phe Gln Cys Ser Gln Cys Asp Met Arg Phe 
        195                 200                 205             


Ile Gln Lys Tyr Leu Leu Gln Arg His Glu Lys Ile His Thr Gly Glu 
    210                 215                 220                 


Lys Pro Phe Arg Cys Asp Glu Cys Gly Met Arg Phe Ile Gln Lys Tyr 
225                 230                 235                 240 


His Met Glu Arg His Lys Arg Thr His Ser Gly Glu Lys Pro Tyr Gln 
                245                 250                 255     


Cys Glu Tyr Cys Leu Gln Tyr Phe Ser Arg Thr Asp Arg Val Leu Lys 
            260                 265                 270         


His Lys Arg Met Cys His Glu Asn His Asp Lys Lys Leu Asn Arg Cys 
        275                 280                 285             


Ala Ile Lys Gly Gly Leu Leu Thr Ser Glu Glu Asp Ser Gly Phe Ser 
    290                 295                 300                 


Thr Ser Pro Lys Asp Asn Ser Leu Pro Lys Lys Lys Arg Gln Lys Thr 
305                 310                 315                 320 


Glu Lys Lys Ser Ser Gly Met Asp Lys Glu Ser Ala Leu Asp Lys Ser 
                325                 330                 335     


Asp Leu Lys Lys Asp Lys Asn Asp Tyr Leu Pro Leu Tyr Ser Ser Ser 
            340                 345                 350         


Thr Lys Val Lys Asp Glu Tyr Met Val Ala Glu Tyr Ala Val Glu Met 
        355                 360                 365             


Pro His Ser Ser Val Gly Gly Ser His Leu Glu Asp Ala Ser Gly Glu 
    370                 375                 380                 


Ile His Pro Pro Lys Leu Val Leu Lys Lys Ile Asn Ser Lys Arg Ser 
385                 390                 395                 400 


Leu Lys Gln Pro Leu Glu Gln Asn Gln Thr Ile Ser Pro Leu Ser Thr 
                405                 410                 415     


Tyr Glu Glu Ser Lys Val Ser Lys Tyr Ala Phe Glu Leu Val Asp Lys 
            420                 425                 430         


Gln Ala Leu Leu Asp Ser Glu Gly Asn Ala Asp Ile Asp Gln Val Asp 
        435                 440                 445             


Asn Leu Gln Glu Gly Pro Ser Lys Pro Val His Ser Ser Thr Asn Tyr 
    450                 455                 460                 


Asp Asp Ala Met Gln Phe Leu Lys Lys Lys Arg Tyr Leu Gln Ala Ala 
465                 470                 475                 480 


Ser Asn Asn Ser Arg Glu Tyr Ala Leu Asn Val Gly Thr Ile Ala Ser 
                485                 490                 495     


Gln Pro Ser Val Thr Gln Ala Ala Val Ala Ser Val Ile Asp Glu Ser 
            500                 505                 510         


Thr Thr Ala Ser Ile Leu Glu Ser Gln Ala Leu Asn Val Glu Ile Lys 
        515                 520                 525             


Ser Asn His Asp Lys Asn Val Ile Pro Asp Glu Val Leu Gln Thr Leu 
    530                 535                 540                 


Leu Asp His Tyr Ser His Lys Ala Asn Gly Gln His Glu Ile Ser Phe 
545                 550                 555                 560 


Ser Val Ala Asp Thr Glu Val Thr Ser Ser Ile Ser Ile Asn Ser Ser 
                565                 570                 575     


Glu Val Pro Glu Val Thr Pro Ser Glu Asn Val Gly Ser Ser Ser Gln 
            580                 585                 590         


Ala Ser Ser Ser Asp Lys Ala Asn Met Leu Gln Glu Tyr Ser Lys Phe 
        595                 600                 605             


Leu Gln Gln Ala Leu Asp Arg Thr Ser Gln Asn Asp Ala Tyr Leu Asn 
    610                 615                 620                 


Ser Pro Ser Leu Asn Phe Val Thr Asp Asn Gln Thr Leu Pro Asn Gln 
625                 630                 635                 640 


Pro Ala Phe Ser Ser Ile Asp Lys Gln Val Tyr Ala Thr Met Pro Ile 
                645                 650                 655     


Asn Ser Phe Arg Ser Gly Met Asn Ser Pro Leu Arg Thr Thr Pro Asp 
            660                 665                 670         


Lys Ser His Phe Gly Leu Ile Val Gly Asp Ser Gln His Ser Phe Pro 
        675                 680                 685             


Phe Ser Gly Asp Glu Thr Asn His Ala Ser Ala Thr Ser Thr Gln Asp 
    690                 695                 700                 


Phe Leu Asp Gln Val Thr Ser Gln Lys Lys Ala Glu Ala Gln Pro Val 
705                 710                 715                 720 


His Gln Ala Tyr Gln Met Ser Ser Phe Glu Gln Pro Phe Arg Ala Pro 
                725                 730                 735     


Tyr His Gly Ser Arg Ala Gly Ile Ala Thr Gln Phe Ser Thr Ala Asn 
            740                 745                 750         


Gly Gln Val Asn Leu Arg Gly Pro Gly Thr Ser Ala Glu Phe Ser Glu 
        755                 760                 765             


Phe Pro Leu Val Asn Val Asn Asp Asn Arg Ala Gly Met Thr Ser Ser 
    770                 775                 780                 


Pro Asp Ala Thr Thr Gly Gln Thr Phe Gly 
785                 790                 

<210>  1740
<211>  9357
<212>  DNA
<213>  Homo sapiens

<400>  1740
agaaaggcgc aggggtggga gctgttgccg aagctgccac agcaaaagtt ctcccccctc     60

cccccttccc ctcctctcaa ggcccctaga aaggttggag ctgccgccgc ctgcagtcgg    120

tgaccgcgcg actcggcgcc cgcccgcgga tagagggagg aatcagcagc ttggaaattc    180

aagcacgtga tctggcggga tgggcgtttg cctaacgtat ttaatggagg aatcggatgg    240

cataagtgat taaggtggta ttgaggattt ctgaagccta tgaaaggcag ttatacttaa    300

gcatgaacat tgacgacaaa ctggaaggat tgtttcttaa atgtggcggc atagacgaaa    360

tgcagtcttc caggacaatg gttgtaatgg gtggagtgtc tggccagtct actgtgtctg    420

gagagctaca ggattcagta cttcaagatc gaagtatgcc tcaccaggag atccttgctg    480

cagatgaagt gttacaagaa agtgaaatga gacaacagga tatgatatca catgatgaac    540

tcatggtcca tgaggagaca gtgaaaaatg atgaagagca gatggaaaca catgaaagac    600

ttcctcaagg actacagtat gcacttaatg tccctataag cgtaaagcag gaaattactt    660

ttactgatgt atctgagcaa ctgatgagag acaaaaaaca aatcagagag ccagtagact    720

tacagaaaaa gaagaagcgg aaacaacgtt ctcccgcaaa aatccttaca ataaatgagg    780

atggatcact tggtttgaaa acccctaaat ctcacgtttg tgagcactgc aatgctgcct    840

ttagaacgaa ctatcactta cagagacatg tcttcattca tacaggtgaa aaaccatttc    900

aatgtagtca atgtgacatg cgtttcatac agaagtacct gcttcagaga catgagaaga    960

ttcatactgg tgaaaaacca tttcgctgtg atgaatgtgg tatgagattc atacaaaaat   1020

atcatatgga aaggcataag agaactcata gtggagaaaa accttaccag tgtgaatact   1080

gtttacagta tttttccaga acagatcgtg tattgaaaca taaacgtatg tgccatgaaa   1140

atcatgacaa aaaactaaat agatgtgcca tcaaaggtgg ccttctgaca tctgaggaag   1200

attctggctt ttctacatca ccaaaagaca actcactgcc aaaaaagaaa aggcagaaaa   1260

cggagaaaaa atcatctgga atggacaaag agagtgcttt ggacaaatct gacctgaaaa   1320

aagacaaaaa tgattacttg cctctttatt cttcaagtac taaagtaaaa gatgagtata   1380

tggttgcaga atatgctgtt gaaatgccac attcgtcagt tgggggctcg catttagaag   1440

atgcgtcagg agaaatacac ccacctaagt tagttctcaa aaaaattaat agtaagagaa   1500

gtctgaaaca gccactggag caaaatcaaa caatttcacc tttatccaca tatgaagaga   1560

gcaaagtttc aaagtatgct tttgaacttg tggataaaca ggctttactg gactcagaag   1620

gcaatgctga cattgatcag gttgataatt tgcaggaggg gcccagtaaa cctgtgcata   1680

gtagtactaa ttatgatgat gccatgcagt ttttgaagaa gaagcggtat cttcaagcag   1740

caagtaacaa cagcagggaa tatgcgctga atgtgggtac catagcttct cagccttctg   1800

taacacaagc agctgtggca agtgtcattg atgaaagtac cacggcatcc atattagagt   1860

cacaggcact gaatgtggag attaagagta atcatgacaa aaatgttatt ccagatgagg   1920

tactgcagac tctgttggat cattattccc acaaagctaa tggacagcat gagatatcct   1980

tcagtgttgc agatactgaa gtgacttcta gcatatcaat aaattcttca gaagtaccag   2040

aggtcacccc gtcagagaat gttggatcaa gctcccaagc atcctcatca gataaagcca   2100

acatgttgca ggaatactcc aagtttctgc agcaggcttt ggacagaact agccaaaatg   2160

atgcctattt gaatagcccg agccttaact ttgtgactga taaccagacc ctcccaaatc   2220

agccagcatt ctcttccata gacaagcagg tctatgccac catgcccatc aatagctttc   2280

gatcaggaat gaattctcca ctaagaacaa ctccagataa gtcccacttt ggactaatag   2340

ttggtgattc acagcactca tttccctttt caggtgatga gacaaaccat gcttctgcca   2400

catcaacaca ggactttctg gatcaagtga cttctcagaa gaaagctgag gcccagcctg   2460

tccaccaagc ttaccaaatg agctcctttg aacagccctt ccgtgctccc tatcatggat   2520

caagagctgg aatagctact caatttagca ctgccaatgg acaggtgaac cttcggggac   2580

cagggacaag tgctgaattt tcagaatttc ccttggtgaa tgtaaatgat aatagagctg   2640

ggatgacatc ttcacctgat gccacaactg gccagacttt tggctaaaaa aaaaaaaaaa   2700

gtgtaaataa tactggcact ttagaacaga ttaatcaaga gtggggttac tctgtgtaaa   2760

tggagtgctg tacagattta agagcaatgc gtaataacaa gttaagctga tatgaatagc   2820

aagataatcc aataactgca tttcgtttgg ttagtcagca ttctttgaac tgccttacat   2880

gttgtcacct ttatagaagc aatgcattac ttgttttaga tcagaaactt gctattccac   2940

ccacaccaag ttaaaaagga aaaaaaaaag actttcgcac aattgtttcc taactgataa   3000

cattgtacat tcttaggaga ttagtaattg tgtgaaattt actcatactg tttctaagtt   3060

tttcagcata gtcattgcac ttcagcaggg aatctgagta tactttacag acagagtgaa   3120

cttaaaagtt taatgtcaag agattatggc ttaaataaat tagtgtgtcc tataggggga   3180

aaaaaaccaa gaaaccacct tttaaaaaga atgatatgcc atataccctt gattttcatt   3240

ttgcattata ttgacgtgtt tttttgaagg aaaaaaagta ataaaaatct gatagtctaa   3300

gactccacta tttaaaagcc taattacttt aaaaatatgc atactttcag aacttttacc   3360

aaaacacaca actgttgaag cagtcacttc tctatggaag tatgcatatt ggtgtcagtt   3420

tctttgtaca gttgtactta gatatttttt atgatttttc atgtgcaggt atcaaggttt   3480

tgaagtttta gtaaaagaaa ttctgtagat tacattccca agaacataat gcttacacaa   3540

aatgtatatt ccacgtttta aagcttaatt gtattttact ttacatatac acttcagtta   3600

acatagagca cttagaatct atttggtatt tttgatttct caaagtaaaa aaaaaattag   3660

atttttaggt ttgatatggt tgtgtcataa tcatctcgta attgacaatt ttaacttttg   3720

gcaataaaag gaaattggga tatctttgga actgtaaaac ctggtttaat ctttttcttt   3780

ctagactctt gatagattgg ataattaaac agtatccaga gaaactaaag aaatgggcat   3840

tttaattgca tattttatct tgagttactt tttaatgaac actgctcatt acaactttac   3900

aaaccaaaag tgtttactaa ttccagtaac taccatttct ttttcagcta gatgagtgat   3960

cggaaaattt ttgttgcatt tcaaaatcta aataaactac agactttatc cttataccat   4020

gaatgttttt ttttaatact ctgtcttaaa ataatacagc atggtacaat aaatagtgct   4080

tttatgtata tatacacaca cacacttttc tgaagaatga tggtttgagt tatgcgttgg   4140

gcagttttga tttttggaag ttatattagt tattgactct ttgttacaac tttttcattt   4200

ttacatttta aattttctgc catcgttgtc acaatgcaca tcctgatata gcaccagtga   4260

aaatctaaaa ttaataccct tggaaaatga aaatattctt aatttccatt ttgactctta   4320

tactggccct atagctctgc agtctttgtt tcaatataga atatgttatc catttaaatt   4380

attttttctt ttatttaatg ttatcccaag actgttctca taaagaaagg gaagaaataa   4440

ctatccaccc ttaacatcct tcatttattt tgaatatatt ggtgttttta tgataaggaa   4500

tataaattat atttaatgtg gtttcctgta tactttggtt attaagtttt gcttgaaata   4560

gtagttttcc cgtttgacag ctttctttgc tgccaaagtt ttcaagaatt taagacttct   4620

ttgaagtaaa tatttaagtt ctgccattat tgactcttaa gattgtgtgt gttgtgttgt   4680

gcattacata attacaaaaa ggcttcattc aggtgatacg ttaaaaatgg aactgtgctc   4740

accctaaata ggcattggta tttttctctt ttggtgagag taggcattta tttcttgagt   4800

tgttttggag cctgatcaaa aattttgttc atggagaact tgatgcaatt ttgatacagt   4860

ggagaggttt ttttcggttg ttttaacatc accagcatag tttttagaat gtgactcttg   4920

ctgagcattt agggtgagct tgggaaggaa ggcctttgaa aatggtagtt atgcaagcag   4980

actttcaggt gttgcattcc tgttttcaac acatttcttt aaatctacat aatggcagac   5040

ttttctacca ggttataagc agtttttaga taagtgatac tcagccagca taacttattg   5100

acttaccatt tacgtatagt catcactctc ttactgtgaa attccaaatg cctaccagag   5160

ttaccttgtt ctatcataat atgacaaaca tctcaacagt tttggatttc cccactttgg   5220

ttcagaaggt tatttaattt ctatctgggc attaatggag aaaataagta gccttgtgtg   5280

ctgcttcaga ttgaaacatg gaggatatga gatattcttc tgcaattcat gtttctcatt   5340

tctcaaagtg agcacattgt tctataaaaa catgctggta cacccttaaa cttttgatca   5400

atctgagtga ggtgtgcttt tcctcttggg acctactcac gtttgaagat tggaaacatc   5460

acgttaggcg aggcagtatc tcttgaacat cttctaaagg gttttttaaa accttattct   5520

cacatatttc atttgtcttg aatatttaag tggctcttaa acgttttggg tctacatgca   5580

aatgtggtac ttaacaaggt aggaatccat cttcttagct ctggctgagg gtgccagcca   5640

tcggtcaggt catttttatc tcaagaggca gaaggcagtt atgtcaagaa ttgtgctcag   5700

ggcaggattt cgtttccaca gaggagagac acttgcagag tgccagctag gttagatctt   5760

ttgccgcttc tttcatttga ttaatttggg tttttaaagg gctgtttaaa aaaaaaaaaa   5820

aaaggccggg aaactttaaa agtaggcatt actgtagtac tgcatttctt agaacatttt   5880

aaactagaac tcattttttt ttcacagtat atttacttga agaagcacta taataatcat   5940

tgagaagtat tttgagtctg aaatttaatt taattttccg tttcaaattg ctttatttca   6000

gggaaataat tttccagttg ttttgctata ttctgcaaat aaaaaccgtg tttccttttt   6060

tcacttaaac tttggtagga aacaaactaa agcagacaaa catttcttgt tatgtttgtt   6120

gctttcttta atccaatgga taaaaaagta aaaccctgta aacattattt tattttttta   6180

tgcaatacca tgctgtaaat atggttcatc aaataaggat gtacctatga ttgaatcttt   6240

aattctgcac agttagagtt tatatataaa cgtgtcttga caatcaagga cttttatgtg   6300

agtcttcctt tatgatgttt attaatgtta tgcattccat ttgttttgaa gtgagtacca   6360

atgtgctaat ttgtattgtc tgaaagtatg taatgttttt acagcttgtt tttaagaatc   6420

tgtaaatatg tacaaacaaa tcacagtact gctttatgtt agaaggcata tgatgttgta   6480

ctgtatgtaa gcaataatac atagcagtgc taactttaca agtagcatca ggaaagttct   6540

aaaaacattt cagagttatt aattatcctt atttcattta ataatgatta tctttaatca   6600

gtttttataa gcaaattcca ttgttcctcc tattggaacg taacactgtt tacacagcat   6660

aattgaagtt gcaggggaga caggctaaat ctgacttcat ctgtactcac tttcactaag   6720

cattgaatgg ccttaccact cttctgcaag atggaggaag accgcaaaac ttagtgccca   6780

tcacactgaa ggaagggatg tggttttttt tcctgcttct gtactgctac ctaactttgt   6840

gatttgcttt ggattttaat atttgtttct gttttagatt caagcccgta agttttgagg   6900

tgacttcagc tccattgtga aatagatagt tctcttcata tttcataact acatttcaat   6960

aattctaaac tttctacatt gatttttaga tacttatttt tcaagcttgg tttctcagct   7020

gatcagatga atttattcaa cttcaataca aagaaagaca aacctattat agtttcaagt   7080

gagtagatat tatactgtac aggacagcta tttgaacaca cacatcactg ctttagaaat   7140

aaaaccgcca atttataaat gtatatgacc tacattttat aggaaaaaat gtttttaaat   7200

gctagtcatt tatataatgt gctttgaagg atttgctagt ccacttctgt cactttttag   7260

tacactggta tcttttatat gtaatgtatg ctttttatta ttgtagcaaa gcatttcagt   7320

agaaagaatt ttgcaacaat atgggggaaa tttttcattg ttggatttga attatactgg   7380

attttatctg tgtagtctta cttgtcttta ttttaatgct gtctgaaggg aacttggtat   7440

ccaaataaag caggtaacct cattttactt caagggcata ctgtgtagtg ctgaatttaa   7500

tctgaaaatc tgatgatttt gaaaagaaaa acaagtttat aaacattgta cagaagaaat   7560

taaatgtgtg tgatggaaat cctgatggtg gagcacgttg aattttctga tatatagtgt   7620

tattttcctg ggatccccta tgccttcttt gtatttcaac taataaagga aaaaccctgt   7680

cattaaaact ggtaagataa taggatattc tgattataca gtattactat tcctatccca   7740

ttttctgacc ttttctcaat cactgtaaat ttttattttc tatttcctat tgataattaa   7800

atatgtacat aatatagaca ctgttgtata gaactaaatg aattgggttg ctatgcttga   7860

gtgggtagtg aaatggaaat atttgatgaa tactgagagt tcctaaaatg ctagagcaaa   7920

tttccgaggg aaaggggggc atcgtgtgtc ttgggaaggt tgcagcaggt tgtttcttca   7980

actccctaag aaatcattgg gaaggactca actgcaaact cgggatcaga tacaaaatgg   8040

gtctttcctt cccctctccc ccaaaaaata ggagcactaa attttaaaat ctactcaggt   8100

gacagttgct ttgcaatgaa acttatcaca ttgaaatttt cagtgttaaa taaaaagaga   8160

tttgtgatat ttttaaatat aaacttttac atcagtagtc agcagcctga caattgaaat   8220

ttggtaagtc gatatatttt aaaatatttt gctctccaaa tagaattgtt tttaaacaat   8280

tgggaggttt tttgtttctt taaatatgtt ttaattgtca ttgtaaaaac aaaatcttgc   8340

ttgaccctat attatgccat gaatgaattg ctgagccttt ataatacagt gacagcttgt   8400

ttcatgcata gtcatggaac atagagatgt tctttaaact gacctattga taagaggttt   8460

aatgagtttc acggctttca acactattgt catatagtta tctttgccat ttggagttta   8520

taaaaccatt ttatgtattg tgatactaaa ggaagttgtt ttgctttact ttaaattgaa   8580

ttattagact aatatttgca aattctgcat tttaaatgtg gacactggct gtttgaaaaa   8640

taaaatatag aatacagttt tatggataat tttcgagctg aatttttcac aatattctga   8700

accaaataac gaatggtaaa tatgcaaaaa tcatggtgca tagatataac cgtaaagaga   8760

aaagaatttc tgtgtggaat taacagttac acaaattggg taacaattat cagggccttt   8820

attatagctt tatgtggaat gttattctaa aatgcaagag tcaaatgtta ctgtcattga   8880

atattttaga cttgaaacgt gtttatcata gagcgaagaa aatatgtgtt cttttcttta   8940

cagataagac tctgttaacc cactgtcagc atacgtggga tttcttttct tttttctttc   9000

attagtggag atttgttttc atccatctac caccttgcca gtaccctagc ttgtgaccag   9060

cgggatgcat tgtaagaaag ttgtctgtgg ttaggagtgc agtctgggtc catggaacaa   9120

atttaaacta attggccctc gcaatgatca gtcctaggac cctggcctta ttattagcat   9180

ggtgctttaa ccaattgtac ataataatac cactgatagt ctactaatgc atttcctaga   9240

tcccagtttt tcttgaatga ttaggaatgg tggggagagg ggaggggaga tattctacat   9300

gatacttctc caatcttcta aagattataa gaaaaaataa aaaattgaag tcacttg      9357


<210>  1741
<211>  794
<212>  PRT
<213>  Homo sapiens

<400>  1741


Met Asn Ile Asp Asp Lys Leu Glu Gly Leu Phe Leu Lys Cys Gly Gly 
1               5                   10                  15      


Ile Asp Glu Met Gln Ser Ser Arg Thr Met Val Val Met Gly Gly Val 
            20                  25                  30          


Ser Gly Gln Ser Thr Val Ser Gly Glu Leu Gln Asp Ser Val Leu Gln 
        35                  40                  45              


Asp Arg Ser Met Pro His Gln Glu Ile Leu Ala Ala Asp Glu Val Leu 
    50                  55                  60                  


Gln Glu Ser Glu Met Arg Gln Gln Asp Met Ile Ser His Asp Glu Leu 
65                  70                  75                  80  


Met Val His Glu Glu Thr Val Lys Asn Asp Glu Glu Gln Met Glu Thr 
                85                  90                  95      


His Glu Arg Leu Pro Gln Gly Leu Gln Tyr Ala Leu Asn Val Pro Ile 
            100                 105                 110         


Ser Val Lys Gln Glu Ile Thr Phe Thr Asp Val Ser Glu Gln Leu Met 
        115                 120                 125             


Arg Asp Lys Lys Gln Ile Arg Glu Pro Val Asp Leu Gln Lys Lys Lys 
    130                 135                 140                 


Lys Arg Lys Gln Arg Ser Pro Ala Lys Ile Leu Thr Ile Asn Glu Asp 
145                 150                 155                 160 


Gly Ser Leu Gly Leu Lys Thr Pro Lys Ser His Val Cys Glu His Cys 
                165                 170                 175     


Asn Ala Ala Phe Arg Thr Asn Tyr His Leu Gln Arg His Val Phe Ile 
            180                 185                 190         


His Thr Gly Glu Lys Pro Phe Gln Cys Ser Gln Cys Asp Met Arg Phe 
        195                 200                 205             


Ile Gln Lys Tyr Leu Leu Gln Arg His Glu Lys Ile His Thr Gly Glu 
    210                 215                 220                 


Lys Pro Phe Arg Cys Asp Glu Cys Gly Met Arg Phe Ile Gln Lys Tyr 
225                 230                 235                 240 


His Met Glu Arg His Lys Arg Thr His Ser Gly Glu Lys Pro Tyr Gln 
                245                 250                 255     


Cys Glu Tyr Cys Leu Gln Tyr Phe Ser Arg Thr Asp Arg Val Leu Lys 
            260                 265                 270         


His Lys Arg Met Cys His Glu Asn His Asp Lys Lys Leu Asn Arg Cys 
        275                 280                 285             


Ala Ile Lys Gly Gly Leu Leu Thr Ser Glu Glu Asp Ser Gly Phe Ser 
    290                 295                 300                 


Thr Ser Pro Lys Asp Asn Ser Leu Pro Lys Lys Lys Arg Gln Lys Thr 
305                 310                 315                 320 


Glu Lys Lys Ser Ser Gly Met Asp Lys Glu Ser Ala Leu Asp Lys Ser 
                325                 330                 335     


Asp Leu Lys Lys Asp Lys Asn Asp Tyr Leu Pro Leu Tyr Ser Ser Ser 
            340                 345                 350         


Thr Lys Val Lys Asp Glu Tyr Met Val Ala Glu Tyr Ala Val Glu Met 
        355                 360                 365             


Pro His Ser Ser Val Gly Gly Ser His Leu Glu Asp Ala Ser Gly Glu 
    370                 375                 380                 


Ile His Pro Pro Lys Leu Val Leu Lys Lys Ile Asn Ser Lys Arg Ser 
385                 390                 395                 400 


Leu Lys Gln Pro Leu Glu Gln Asn Gln Thr Ile Ser Pro Leu Ser Thr 
                405                 410                 415     


Tyr Glu Glu Ser Lys Val Ser Lys Tyr Ala Phe Glu Leu Val Asp Lys 
            420                 425                 430         


Gln Ala Leu Leu Asp Ser Glu Gly Asn Ala Asp Ile Asp Gln Val Asp 
        435                 440                 445             


Asn Leu Gln Glu Gly Pro Ser Lys Pro Val His Ser Ser Thr Asn Tyr 
    450                 455                 460                 


Asp Asp Ala Met Gln Phe Leu Lys Lys Lys Arg Tyr Leu Gln Ala Ala 
465                 470                 475                 480 


Ser Asn Asn Ser Arg Glu Tyr Ala Leu Asn Val Gly Thr Ile Ala Ser 
                485                 490                 495     


Gln Pro Ser Val Thr Gln Ala Ala Val Ala Ser Val Ile Asp Glu Ser 
            500                 505                 510         


Thr Thr Ala Ser Ile Leu Glu Ser Gln Ala Leu Asn Val Glu Ile Lys 
        515                 520                 525             


Ser Asn His Asp Lys Asn Val Ile Pro Asp Glu Val Leu Gln Thr Leu 
    530                 535                 540                 


Leu Asp His Tyr Ser His Lys Ala Asn Gly Gln His Glu Ile Ser Phe 
545                 550                 555                 560 


Ser Val Ala Asp Thr Glu Val Thr Ser Ser Ile Ser Ile Asn Ser Ser 
                565                 570                 575     


Glu Val Pro Glu Val Thr Pro Ser Glu Asn Val Gly Ser Ser Ser Gln 
            580                 585                 590         


Ala Ser Ser Ser Asp Lys Ala Asn Met Leu Gln Glu Tyr Ser Lys Phe 
        595                 600                 605             


Leu Gln Gln Ala Leu Asp Arg Thr Ser Gln Asn Asp Ala Tyr Leu Asn 
    610                 615                 620                 


Ser Pro Ser Leu Asn Phe Val Thr Asp Asn Gln Thr Leu Pro Asn Gln 
625                 630                 635                 640 


Pro Ala Phe Ser Ser Ile Asp Lys Gln Val Tyr Ala Thr Met Pro Ile 
                645                 650                 655     


Asn Ser Phe Arg Ser Gly Met Asn Ser Pro Leu Arg Thr Thr Pro Asp 
            660                 665                 670         


Lys Ser His Phe Gly Leu Ile Val Gly Asp Ser Gln His Ser Phe Pro 
        675                 680                 685             


Phe Ser Gly Asp Glu Thr Asn His Ala Ser Ala Thr Ser Thr Gln Asp 
    690                 695                 700                 


Phe Leu Asp Gln Val Thr Ser Gln Lys Lys Ala Glu Ala Gln Pro Val 
705                 710                 715                 720 


His Gln Ala Tyr Gln Met Ser Ser Phe Glu Gln Pro Phe Arg Ala Pro 
                725                 730                 735     


Tyr His Gly Ser Arg Ala Gly Ile Ala Thr Gln Phe Ser Thr Ala Asn 
            740                 745                 750         


Gly Gln Val Asn Leu Arg Gly Pro Gly Thr Ser Ala Glu Phe Ser Glu 
        755                 760                 765             


Phe Pro Leu Val Asn Val Asn Asp Asn Arg Ala Gly Met Thr Ser Ser 
    770                 775                 780                 


Pro Asp Ala Thr Thr Gly Gln Thr Phe Gly 
785                 790                 

<210>  1742
<211>  9357
<212>  DNA
<213>  Homo sapiens

<400>  1742
ggagaaaggc gcaggggtgg gagctgttgc cgaagctgcc acagcaaaag ttctcccccc     60

tccccccttc ccctcctctc aaggccccta gaaaggttgg agctgccgcc gcctgcagtc    120

ggtgaccgcg cgactcggcg cccgcccgcg gaatcggatg gcataagtga ttaaggtggt    180

attgaggatt tctgaagcct atgaaaggta gaaactcaac catgatttct ttttcaactc    240

tacagcattc ctttccttga agtcttcgtt tttaccttag tctcgggcag ttatacttaa    300

gcatgaacat tgacgacaaa ctggaaggat tgtttcttaa atgtggcggc atagacgaaa    360

tgcagtcttc caggacaatg gttgtaatgg gtggagtgtc tggccagtct actgtgtctg    420

gagagctaca ggattcagta cttcaagatc gaagtatgcc tcaccaggag atccttgctg    480

cagatgaagt gttacaagaa agtgaaatga gacaacagga tatgatatca catgatgaac    540

tcatggtcca tgaggagaca gtgaaaaatg atgaagagca gatggaaaca catgaaagac    600

ttcctcaagg actacagtat gcacttaatg tccctataag cgtaaagcag gaaattactt    660

ttactgatgt atctgagcaa ctgatgagag acaaaaaaca aatcagagag ccagtagact    720

tacagaaaaa gaagaagcgg aaacaacgtt ctcccgcaaa aatccttaca ataaatgagg    780

atggatcact tggtttgaaa acccctaaat ctcacgtttg tgagcactgc aatgctgcct    840

ttagaacgaa ctatcactta cagagacatg tcttcattca tacaggtgaa aaaccatttc    900

aatgtagtca atgtgacatg cgtttcatac agaagtacct gcttcagaga catgagaaga    960

ttcatactgg tgaaaaacca tttcgctgtg atgaatgtgg tatgagattc atacaaaaat   1020

atcatatgga aaggcataag agaactcata gtggagaaaa accttaccag tgtgaatact   1080

gtttacagta tttttccaga acagatcgtg tattgaaaca taaacgtatg tgccatgaaa   1140

atcatgacaa aaaactaaat agatgtgcca tcaaaggtgg ccttctgaca tctgaggaag   1200

attctggctt ttctacatca ccaaaagaca actcactgcc aaaaaagaaa aggcagaaaa   1260

cggagaaaaa atcatctgga atggacaaag agagtgcttt ggacaaatct gacctgaaaa   1320

aagacaaaaa tgattacttg cctctttatt cttcaagtac taaagtaaaa gatgagtata   1380

tggttgcaga atatgctgtt gaaatgccac attcgtcagt tgggggctcg catttagaag   1440

atgcgtcagg agaaatacac ccacctaagt tagttctcaa aaaaattaat agtaagagaa   1500

gtctgaaaca gccactggag caaaatcaaa caatttcacc tttatccaca tatgaagaga   1560

gcaaagtttc aaagtatgct tttgaacttg tggataaaca ggctttactg gactcagaag   1620

gcaatgctga cattgatcag gttgataatt tgcaggaggg gcccagtaaa cctgtgcata   1680

gtagtactaa ttatgatgat gccatgcagt ttttgaagaa gaagcggtat cttcaagcag   1740

caagtaacaa cagcagggaa tatgcgctga atgtgggtac catagcttct cagccttctg   1800

taacacaagc agctgtggca agtgtcattg atgaaagtac cacggcatcc atattagagt   1860

cacaggcact gaatgtggag attaagagta atcatgacaa aaatgttatt ccagatgagg   1920

tactgcagac tctgttggat cattattccc acaaagctaa tggacagcat gagatatcct   1980

tcagtgttgc agatactgaa gtgacttcta gcatatcaat aaattcttca gaagtaccag   2040

aggtcacccc gtcagagaat gttggatcaa gctcccaagc atcctcatca gataaagcca   2100

acatgttgca ggaatactcc aagtttctgc agcaggcttt ggacagaact agccaaaatg   2160

atgcctattt gaatagcccg agccttaact ttgtgactga taaccagacc ctcccaaatc   2220

agccagcatt ctcttccata gacaagcagg tctatgccac catgcccatc aatagctttc   2280

gatcaggaat gaattctcca ctaagaacaa ctccagataa gtcccacttt ggactaatag   2340

ttggtgattc acagcactca tttccctttt caggtgatga gacaaaccat gcttctgcca   2400

catcaacaca ggactttctg gatcaagtga cttctcagaa gaaagctgag gcccagcctg   2460

tccaccaagc ttaccaaatg agctcctttg aacagccctt ccgtgctccc tatcatggat   2520

caagagctgg aatagctact caatttagca ctgccaatgg acaggtgaac cttcggggac   2580

cagggacaag tgctgaattt tcagaatttc ccttggtgaa tgtaaatgat aatagagctg   2640

ggatgacatc ttcacctgat gccacaactg gccagacttt tggctaaaaa aaaaaaaaaa   2700

gtgtaaataa tactggcact ttagaacaga ttaatcaaga gtggggttac tctgtgtaaa   2760

tggagtgctg tacagattta agagcaatgc gtaataacaa gttaagctga tatgaatagc   2820

aagataatcc aataactgca tttcgtttgg ttagtcagca ttctttgaac tgccttacat   2880

gttgtcacct ttatagaagc aatgcattac ttgttttaga tcagaaactt gctattccac   2940

ccacaccaag ttaaaaagga aaaaaaaaag actttcgcac aattgtttcc taactgataa   3000

cattgtacat tcttaggaga ttagtaattg tgtgaaattt actcatactg tttctaagtt   3060

tttcagcata gtcattgcac ttcagcaggg aatctgagta tactttacag acagagtgaa   3120

cttaaaagtt taatgtcaag agattatggc ttaaataaat tagtgtgtcc tataggggga   3180

aaaaaaccaa gaaaccacct tttaaaaaga atgatatgcc atataccctt gattttcatt   3240

ttgcattata ttgacgtgtt tttttgaagg aaaaaaagta ataaaaatct gatagtctaa   3300

gactccacta tttaaaagcc taattacttt aaaaatatgc atactttcag aacttttacc   3360

aaaacacaca actgttgaag cagtcacttc tctatggaag tatgcatatt ggtgtcagtt   3420

tctttgtaca gttgtactta gatatttttt atgatttttc atgtgcaggt atcaaggttt   3480

tgaagtttta gtaaaagaaa ttctgtagat tacattccca agaacataat gcttacacaa   3540

aatgtatatt ccacgtttta aagcttaatt gtattttact ttacatatac acttcagtta   3600

acatagagca cttagaatct atttggtatt tttgatttct caaagtaaaa aaaaaattag   3660

atttttaggt ttgatatggt tgtgtcataa tcatctcgta attgacaatt ttaacttttg   3720

gcaataaaag gaaattggga tatctttgga actgtaaaac ctggtttaat ctttttcttt   3780

ctagactctt gatagattgg ataattaaac agtatccaga gaaactaaag aaatgggcat   3840

tttaattgca tattttatct tgagttactt tttaatgaac actgctcatt acaactttac   3900

aaaccaaaag tgtttactaa ttccagtaac taccatttct ttttcagcta gatgagtgat   3960

cggaaaattt ttgttgcatt tcaaaatcta aataaactac agactttatc cttataccat   4020

gaatgttttt ttttaatact ctgtcttaaa ataatacagc atggtacaat aaatagtgct   4080

tttatgtata tatacacaca cacacttttc tgaagaatga tggtttgagt tatgcgttgg   4140

gcagttttga tttttggaag ttatattagt tattgactct ttgttacaac tttttcattt   4200

ttacatttta aattttctgc catcgttgtc acaatgcaca tcctgatata gcaccagtga   4260

aaatctaaaa ttaataccct tggaaaatga aaatattctt aatttccatt ttgactctta   4320

tactggccct atagctctgc agtctttgtt tcaatataga atatgttatc catttaaatt   4380

attttttctt ttatttaatg ttatcccaag actgttctca taaagaaagg gaagaaataa   4440

ctatccaccc ttaacatcct tcatttattt tgaatatatt ggtgttttta tgataaggaa   4500

tataaattat atttaatgtg gtttcctgta tactttggtt attaagtttt gcttgaaata   4560

gtagttttcc cgtttgacag ctttctttgc tgccaaagtt ttcaagaatt taagacttct   4620

ttgaagtaaa tatttaagtt ctgccattat tgactcttaa gattgtgtgt gttgtgttgt   4680

gcattacata attacaaaaa ggcttcattc aggtgatacg ttaaaaatgg aactgtgctc   4740

accctaaata ggcattggta tttttctctt ttggtgagag taggcattta tttcttgagt   4800

tgttttggag cctgatcaaa aattttgttc atggagaact tgatgcaatt ttgatacagt   4860

ggagaggttt ttttcggttg ttttaacatc accagcatag tttttagaat gtgactcttg   4920

ctgagcattt agggtgagct tgggaaggaa ggcctttgaa aatggtagtt atgcaagcag   4980

actttcaggt gttgcattcc tgttttcaac acatttcttt aaatctacat aatggcagac   5040

ttttctacca ggttataagc agtttttaga taagtgatac tcagccagca taacttattg   5100

acttaccatt tacgtatagt catcactctc ttactgtgaa attccaaatg cctaccagag   5160

ttaccttgtt ctatcataat atgacaaaca tctcaacagt tttggatttc cccactttgg   5220

ttcagaaggt tatttaattt ctatctgggc attaatggag aaaataagta gccttgtgtg   5280

ctgcttcaga ttgaaacatg gaggatatga gatattcttc tgcaattcat gtttctcatt   5340

tctcaaagtg agcacattgt tctataaaaa catgctggta cacccttaaa cttttgatca   5400

atctgagtga ggtgtgcttt tcctcttggg acctactcac gtttgaagat tggaaacatc   5460

acgttaggcg aggcagtatc tcttgaacat cttctaaagg gttttttaaa accttattct   5520

cacatatttc atttgtcttg aatatttaag tggctcttaa acgttttggg tctacatgca   5580

aatgtggtac ttaacaaggt aggaatccat cttcttagct ctggctgagg gtgccagcca   5640

tcggtcaggt catttttatc tcaagaggca gaaggcagtt atgtcaagaa ttgtgctcag   5700

ggcaggattt cgtttccaca gaggagagac acttgcagag tgccagctag gttagatctt   5760

ttgccgcttc tttcatttga ttaatttggg tttttaaagg gctgtttaaa aaaaaaaaaa   5820

aaaggccggg aaactttaaa agtaggcatt actgtagtac tgcatttctt agaacatttt   5880

aaactagaac tcattttttt ttcacagtat atttacttga agaagcacta taataatcat   5940

tgagaagtat tttgagtctg aaatttaatt taattttccg tttcaaattg ctttatttca   6000

gggaaataat tttccagttg ttttgctata ttctgcaaat aaaaaccgtg tttccttttt   6060

tcacttaaac tttggtagga aacaaactaa agcagacaaa catttcttgt tatgtttgtt   6120

gctttcttta atccaatgga taaaaaagta aaaccctgta aacattattt tattttttta   6180

tgcaatacca tgctgtaaat atggttcatc aaataaggat gtacctatga ttgaatcttt   6240

aattctgcac agttagagtt tatatataaa cgtgtcttga caatcaagga cttttatgtg   6300

agtcttcctt tatgatgttt attaatgtta tgcattccat ttgttttgaa gtgagtacca   6360

atgtgctaat ttgtattgtc tgaaagtatg taatgttttt acagcttgtt tttaagaatc   6420

tgtaaatatg tacaaacaaa tcacagtact gctttatgtt agaaggcata tgatgttgta   6480

ctgtatgtaa gcaataatac atagcagtgc taactttaca agtagcatca ggaaagttct   6540

aaaaacattt cagagttatt aattatcctt atttcattta ataatgatta tctttaatca   6600

gtttttataa gcaaattcca ttgttcctcc tattggaacg taacactgtt tacacagcat   6660

aattgaagtt gcaggggaga caggctaaat ctgacttcat ctgtactcac tttcactaag   6720

cattgaatgg ccttaccact cttctgcaag atggaggaag accgcaaaac ttagtgccca   6780

tcacactgaa ggaagggatg tggttttttt tcctgcttct gtactgctac ctaactttgt   6840

gatttgcttt ggattttaat atttgtttct gttttagatt caagcccgta agttttgagg   6900

tgacttcagc tccattgtga aatagatagt tctcttcata tttcataact acatttcaat   6960

aattctaaac tttctacatt gatttttaga tacttatttt tcaagcttgg tttctcagct   7020

gatcagatga atttattcaa cttcaataca aagaaagaca aacctattat agtttcaagt   7080

gagtagatat tatactgtac aggacagcta tttgaacaca cacatcactg ctttagaaat   7140

aaaaccgcca atttataaat gtatatgacc tacattttat aggaaaaaat gtttttaaat   7200

gctagtcatt tatataatgt gctttgaagg atttgctagt ccacttctgt cactttttag   7260

tacactggta tcttttatat gtaatgtatg ctttttatta ttgtagcaaa gcatttcagt   7320

agaaagaatt ttgcaacaat atgggggaaa tttttcattg ttggatttga attatactgg   7380

attttatctg tgtagtctta cttgtcttta ttttaatgct gtctgaaggg aacttggtat   7440

ccaaataaag caggtaacct cattttactt caagggcata ctgtgtagtg ctgaatttaa   7500

tctgaaaatc tgatgatttt gaaaagaaaa acaagtttat aaacattgta cagaagaaat   7560

taaatgtgtg tgatggaaat cctgatggtg gagcacgttg aattttctga tatatagtgt   7620

tattttcctg ggatccccta tgccttcttt gtatttcaac taataaagga aaaaccctgt   7680

cattaaaact ggtaagataa taggatattc tgattataca gtattactat tcctatccca   7740

ttttctgacc ttttctcaat cactgtaaat ttttattttc tatttcctat tgataattaa   7800

atatgtacat aatatagaca ctgttgtata gaactaaatg aattgggttg ctatgcttga   7860

gtgggtagtg aaatggaaat atttgatgaa tactgagagt tcctaaaatg ctagagcaaa   7920

tttccgaggg aaaggggggc atcgtgtgtc ttgggaaggt tgcagcaggt tgtttcttca   7980

actccctaag aaatcattgg gaaggactca actgcaaact cgggatcaga tacaaaatgg   8040

gtctttcctt cccctctccc ccaaaaaata ggagcactaa attttaaaat ctactcaggt   8100

gacagttgct ttgcaatgaa acttatcaca ttgaaatttt cagtgttaaa taaaaagaga   8160

tttgtgatat ttttaaatat aaacttttac atcagtagtc agcagcctga caattgaaat   8220

ttggtaagtc gatatatttt aaaatatttt gctctccaaa tagaattgtt tttaaacaat   8280

tgggaggttt tttgtttctt taaatatgtt ttaattgtca ttgtaaaaac aaaatcttgc   8340

ttgaccctat attatgccat gaatgaattg ctgagccttt ataatacagt gacagcttgt   8400

ttcatgcata gtcatggaac atagagatgt tctttaaact gacctattga taagaggttt   8460

aatgagtttc acggctttca acactattgt catatagtta tctttgccat ttggagttta   8520

taaaaccatt ttatgtattg tgatactaaa ggaagttgtt ttgctttact ttaaattgaa   8580

ttattagact aatatttgca aattctgcat tttaaatgtg gacactggct gtttgaaaaa   8640

taaaatatag aatacagttt tatggataat tttcgagctg aatttttcac aatattctga   8700

accaaataac gaatggtaaa tatgcaaaaa tcatggtgca tagatataac cgtaaagaga   8760

aaagaatttc tgtgtggaat taacagttac acaaattggg taacaattat cagggccttt   8820

attatagctt tatgtggaat gttattctaa aatgcaagag tcaaatgtta ctgtcattga   8880

atattttaga cttgaaacgt gtttatcata gagcgaagaa aatatgtgtt cttttcttta   8940

cagataagac tctgttaacc cactgtcagc atacgtggga tttcttttct tttttctttc   9000

attagtggag atttgttttc atccatctac caccttgcca gtaccctagc ttgtgaccag   9060

cgggatgcat tgtaagaaag ttgtctgtgg ttaggagtgc agtctgggtc catggaacaa   9120

atttaaacta attggccctc gcaatgatca gtcctaggac cctggcctta ttattagcat   9180

ggtgctttaa ccaattgtac ataataatac cactgatagt ctactaatgc atttcctaga   9240

tcccagtttt tcttgaatga ttaggaatgg tggggagagg ggaggggaga tattctacat   9300

gatacttctc caatcttcta aagattataa gaaaaaataa aaaattgaag tcacttg      9357


<210>  1743
<211>  794
<212>  PRT
<213>  Homo sapiens

<400>  1743


Met Asn Ile Asp Asp Lys Leu Glu Gly Leu Phe Leu Lys Cys Gly Gly 
1               5                   10                  15      


Ile Asp Glu Met Gln Ser Ser Arg Thr Met Val Val Met Gly Gly Val 
            20                  25                  30          


Ser Gly Gln Ser Thr Val Ser Gly Glu Leu Gln Asp Ser Val Leu Gln 
        35                  40                  45              


Asp Arg Ser Met Pro His Gln Glu Ile Leu Ala Ala Asp Glu Val Leu 
    50                  55                  60                  


Gln Glu Ser Glu Met Arg Gln Gln Asp Met Ile Ser His Asp Glu Leu 
65                  70                  75                  80  


Met Val His Glu Glu Thr Val Lys Asn Asp Glu Glu Gln Met Glu Thr 
                85                  90                  95      


His Glu Arg Leu Pro Gln Gly Leu Gln Tyr Ala Leu Asn Val Pro Ile 
            100                 105                 110         


Ser Val Lys Gln Glu Ile Thr Phe Thr Asp Val Ser Glu Gln Leu Met 
        115                 120                 125             


Arg Asp Lys Lys Gln Ile Arg Glu Pro Val Asp Leu Gln Lys Lys Lys 
    130                 135                 140                 


Lys Arg Lys Gln Arg Ser Pro Ala Lys Ile Leu Thr Ile Asn Glu Asp 
145                 150                 155                 160 


Gly Ser Leu Gly Leu Lys Thr Pro Lys Ser His Val Cys Glu His Cys 
                165                 170                 175     


Asn Ala Ala Phe Arg Thr Asn Tyr His Leu Gln Arg His Val Phe Ile 
            180                 185                 190         


His Thr Gly Glu Lys Pro Phe Gln Cys Ser Gln Cys Asp Met Arg Phe 
        195                 200                 205             


Ile Gln Lys Tyr Leu Leu Gln Arg His Glu Lys Ile His Thr Gly Glu 
    210                 215                 220                 


Lys Pro Phe Arg Cys Asp Glu Cys Gly Met Arg Phe Ile Gln Lys Tyr 
225                 230                 235                 240 


His Met Glu Arg His Lys Arg Thr His Ser Gly Glu Lys Pro Tyr Gln 
                245                 250                 255     


Cys Glu Tyr Cys Leu Gln Tyr Phe Ser Arg Thr Asp Arg Val Leu Lys 
            260                 265                 270         


His Lys Arg Met Cys His Glu Asn His Asp Lys Lys Leu Asn Arg Cys 
        275                 280                 285             


Ala Ile Lys Gly Gly Leu Leu Thr Ser Glu Glu Asp Ser Gly Phe Ser 
    290                 295                 300                 


Thr Ser Pro Lys Asp Asn Ser Leu Pro Lys Lys Lys Arg Gln Lys Thr 
305                 310                 315                 320 


Glu Lys Lys Ser Ser Gly Met Asp Lys Glu Ser Ala Leu Asp Lys Ser 
                325                 330                 335     


Asp Leu Lys Lys Asp Lys Asn Asp Tyr Leu Pro Leu Tyr Ser Ser Ser 
            340                 345                 350         


Thr Lys Val Lys Asp Glu Tyr Met Val Ala Glu Tyr Ala Val Glu Met 
        355                 360                 365             


Pro His Ser Ser Val Gly Gly Ser His Leu Glu Asp Ala Ser Gly Glu 
    370                 375                 380                 


Ile His Pro Pro Lys Leu Val Leu Lys Lys Ile Asn Ser Lys Arg Ser 
385                 390                 395                 400 


Leu Lys Gln Pro Leu Glu Gln Asn Gln Thr Ile Ser Pro Leu Ser Thr 
                405                 410                 415     


Tyr Glu Glu Ser Lys Val Ser Lys Tyr Ala Phe Glu Leu Val Asp Lys 
            420                 425                 430         


Gln Ala Leu Leu Asp Ser Glu Gly Asn Ala Asp Ile Asp Gln Val Asp 
        435                 440                 445             


Asn Leu Gln Glu Gly Pro Ser Lys Pro Val His Ser Ser Thr Asn Tyr 
    450                 455                 460                 


Asp Asp Ala Met Gln Phe Leu Lys Lys Lys Arg Tyr Leu Gln Ala Ala 
465                 470                 475                 480 


Ser Asn Asn Ser Arg Glu Tyr Ala Leu Asn Val Gly Thr Ile Ala Ser 
                485                 490                 495     


Gln Pro Ser Val Thr Gln Ala Ala Val Ala Ser Val Ile Asp Glu Ser 
            500                 505                 510         


Thr Thr Ala Ser Ile Leu Glu Ser Gln Ala Leu Asn Val Glu Ile Lys 
        515                 520                 525             


Ser Asn His Asp Lys Asn Val Ile Pro Asp Glu Val Leu Gln Thr Leu 
    530                 535                 540                 


Leu Asp His Tyr Ser His Lys Ala Asn Gly Gln His Glu Ile Ser Phe 
545                 550                 555                 560 


Ser Val Ala Asp Thr Glu Val Thr Ser Ser Ile Ser Ile Asn Ser Ser 
                565                 570                 575     


Glu Val Pro Glu Val Thr Pro Ser Glu Asn Val Gly Ser Ser Ser Gln 
            580                 585                 590         


Ala Ser Ser Ser Asp Lys Ala Asn Met Leu Gln Glu Tyr Ser Lys Phe 
        595                 600                 605             


Leu Gln Gln Ala Leu Asp Arg Thr Ser Gln Asn Asp Ala Tyr Leu Asn 
    610                 615                 620                 


Ser Pro Ser Leu Asn Phe Val Thr Asp Asn Gln Thr Leu Pro Asn Gln 
625                 630                 635                 640 


Pro Ala Phe Ser Ser Ile Asp Lys Gln Val Tyr Ala Thr Met Pro Ile 
                645                 650                 655     


Asn Ser Phe Arg Ser Gly Met Asn Ser Pro Leu Arg Thr Thr Pro Asp 
            660                 665                 670         


Lys Ser His Phe Gly Leu Ile Val Gly Asp Ser Gln His Ser Phe Pro 
        675                 680                 685             


Phe Ser Gly Asp Glu Thr Asn His Ala Ser Ala Thr Ser Thr Gln Asp 
    690                 695                 700                 


Phe Leu Asp Gln Val Thr Ser Gln Lys Lys Ala Glu Ala Gln Pro Val 
705                 710                 715                 720 


His Gln Ala Tyr Gln Met Ser Ser Phe Glu Gln Pro Phe Arg Ala Pro 
                725                 730                 735     


Tyr His Gly Ser Arg Ala Gly Ile Ala Thr Gln Phe Ser Thr Ala Asn 
            740                 745                 750         


Gly Gln Val Asn Leu Arg Gly Pro Gly Thr Ser Ala Glu Phe Ser Glu 
        755                 760                 765             


Phe Pro Leu Val Asn Val Asn Asp Asn Arg Ala Gly Met Thr Ser Ser 
    770                 775                 780                 


Pro Asp Ala Thr Thr Gly Gln Thr Phe Gly 
785                 790                 

<210>  1744
<211>  7413
<212>  DNA
<213>  Homo sapiens

<400>  1744
ggaggaggag gaggaggggg aggaagagga gaaaggcgca ggggtgggag ctgttgccga     60

agctgccaca gcaaaagttc tcccccctcc ccccttcccc tcctctcaag gcccctagaa    120

aggttggagc tgccgccgcc tgcagtcggt gaccgcgcga ctcggcgccc gcccgcggat    180

agagggagga atcagcagct tggaaattca agcacgtgat ctggcgggat gggcgtttgc    240

ctaacgtatt taatggagga atcggatggc ataagtgatt aaggtggtat tgaggatttc    300

tgaagcctat gaaaggtgaa aaaccatttc aatgtagtca atgtgacatg cgtttcatac    360

agaagtacct gcttcagaga catgagaaga ttcatactgg tgaaaaacca tttcgctgtg    420

atgaatgtgg tgatgagaca aaccatgctt ctgccacatc aacacaggac tttctggatc    480

aagtgacttc tcagaagaaa gctgaggccc agcctgtcca ccaagcttac caaatgagct    540

cctttgaaca gcccttccgt gctccctatc atggatcaag agctggaata gctactcaat    600

ttagcactgc caatggacag gtgaaccttc ggggaccagg gacaagtgct gaattttcag    660

aatttccctt ggtgaatgta aatgataata gagctgggat gacatcttca cctgatgcca    720

caactggcca gacttttggc taaaaaaaaa aaaaaagtgt aaataatact ggcactttag    780

aacagattaa tcaagagtgg ggttactctg tgtaaatgga gtgctgtaca gatttaagag    840

caatgcgtaa taacaagtta agctgatatg aatagcaaga taatccaata actgcatttc    900

gtttggttag tcagcattct ttgaactgcc ttacatgttg tcacctttat agaagcaatg    960

cattacttgt tttagatcag aaacttgcta ttccacccac accaagttaa aaaggaaaaa   1020

aaaaagactt tcgcacaatt gtttcctaac tgataacatt gtacattctt aggagattag   1080

taattgtgtg aaatttactc atactgtttc taagtttttc agcatagtca ttgcacttca   1140

gcagggaatc tgagtatact ttacagacag agtgaactta aaagtttaat gtcaagagat   1200

tatggcttaa ataaattagt gtgtcctata gggggaaaaa aaccaagaaa ccacctttta   1260

aaaagaatga tatgccatat acccttgatt ttcattttgc attatattga cgtgtttttt   1320

tgaaggaaaa aaagtaataa aaatctgata gtctaagact ccactattta aaagcctaat   1380

tactttaaaa atatgcatac tttcagaact tttaccaaaa cacacaactg ttgaagcagt   1440

cacttctcta tggaagtatg catattggtg tcagtttctt tgtacagttg tacttagata   1500

ttttttatga tttttcatgt gcaggtatca aggttttgaa gttttagtaa aagaaattct   1560

gtagattaca ttcccaagaa cataatgctt acacaaaatg tatattccac gttttaaagc   1620

ttaattgtat tttactttac atatacactt cagttaacat agagcactta gaatctattt   1680

ggtatttttg atttctcaaa gtaaaaaaaa aattagattt ttaggtttga tatggttgtg   1740

tcataatcat ctcgtaattg acaattttaa cttttggcaa taaaaggaaa ttgggatatc   1800

tttggaactg taaaacctgg tttaatcttt ttctttctag actcttgata gattggataa   1860

ttaaacagta tccagagaaa ctaaagaaat gggcatttta attgcatatt ttatcttgag   1920

ttacttttta atgaacactg ctcattacaa ctttacaaac caaaagtgtt tactaattcc   1980

agtaactacc atttcttttt cagctagatg agtgatcgga aaatttttgt tgcatttcaa   2040

aatctaaata aactacagac tttatcctta taccatgaat gttttttttt aatactctgt   2100

cttaaaataa tacagcatgg tacaataaat agtgctttta tgtatatata cacacacaca   2160

cttttctgaa gaatgatggt ttgagttatg cgttgggcag ttttgatttt tggaagttat   2220

attagttatt gactctttgt tacaactttt tcatttttac attttaaatt ttctgccatc   2280

gttgtcacaa tgcacatcct gatatagcac cagtgaaaat ctaaaattaa tacccttgga   2340

aaatgaaaat attcttaatt tccattttga ctcttatact ggccctatag ctctgcagtc   2400

tttgtttcaa tatagaatat gttatccatt taaattattt tttcttttat ttaatgttat   2460

cccaagactg ttctcataaa gaaagggaag aaataactat ccacccttaa catccttcat   2520

ttattttgaa tatattggtg tttttatgat aaggaatata aattatattt aatgtggttt   2580

cctgtatact ttggttatta agttttgctt gaaatagtag ttttcccgtt tgacagcttt   2640

ctttgctgcc aaagttttca agaatttaag acttctttga agtaaatatt taagttctgc   2700

cattattgac tcttaagatt gtgtgtgttg tgttgtgcat tacataatta caaaaaggct   2760

tcattcaggt gatacgttaa aaatggaact gtgctcaccc taaataggca ttggtatttt   2820

tctcttttgg tgagagtagg catttatttc ttgagttgtt ttggagcctg atcaaaaatt   2880

ttgttcatgg agaacttgat gcaattttga tacagtggag aggttttttt cggttgtttt   2940

aacatcacca gcatagtttt tagaatgtga ctcttgctga gcatttaggg tgagcttggg   3000

aaggaaggcc tttgaaaatg gtagttatgc aagcagactt tcaggtgttg cattcctgtt   3060

ttcaacacat ttctttaaat ctacataatg gcagactttt ctaccaggtt ataagcagtt   3120

tttagataag tgatactcag ccagcataac ttattgactt accatttacg tatagtcatc   3180

actctcttac tgtgaaattc caaatgccta ccagagttac cttgttctat cataatatga   3240

caaacatctc aacagttttg gatttcccca ctttggttca gaaggttatt taatttctat   3300

ctgggcatta atggagaaaa taagtagcct tgtgtgctgc ttcagattga aacatggagg   3360

atatgagata ttcttctgca attcatgttt ctcatttctc aaagtgagca cattgttcta   3420

taaaaacatg ctggtacacc cttaaacttt tgatcaatct gagtgaggtg tgcttttcct   3480

cttgggacct actcacgttt gaagattgga aacatcacgt taggcgaggc agtatctctt   3540

gaacatcttc taaagggttt tttaaaacct tattctcaca tatttcattt gtcttgaata   3600

tttaagtggc tcttaaacgt tttgggtcta catgcaaatg tggtacttaa caaggtagga   3660

atccatcttc ttagctctgg ctgagggtgc cagccatcgg tcaggtcatt tttatctcaa   3720

gaggcagaag gcagttatgt caagaattgt gctcagggca ggatttcgtt tccacagagg   3780

agagacactt gcagagtgcc agctaggtta gatcttttgc cgcttctttc atttgattaa   3840

tttgggtttt taaagggctg tttaaaaaaa aaaaaaaaag gccgggaaac tttaaaagta   3900

ggcattactg tagtactgca tttcttagaa cattttaaac tagaactcat ttttttttca   3960

cagtatattt acttgaagaa gcactataat aatcattgag aagtattttg agtctgaaat   4020

ttaatttaat tttccgtttc aaattgcttt atttcaggga aataattttc cagttgtttt   4080

gctatattct gcaaataaaa accgtgtttc cttttttcac ttaaactttg gtaggaaaca   4140

aactaaagca gacaaacatt tcttgttatg tttgttgctt tctttaatcc aatggataaa   4200

aaagtaaaac cctgtaaaca ttattttatt tttttatgca ataccatgct gtaaatatgg   4260

ttcatcaaat aaggatgtac ctatgattga atctttaatt ctgcacagtt agagtttata   4320

tataaacgtg tcttgacaat caaggacttt tatgtgagtc ttcctttatg atgtttatta   4380

atgttatgca ttccatttgt tttgaagtga gtaccaatgt gctaatttgt attgtctgaa   4440

agtatgtaat gtttttacag cttgttttta agaatctgta aatatgtaca aacaaatcac   4500

agtactgctt tatgttagaa ggcatatgat gttgtactgt atgtaagcaa taatacatag   4560

cagtgctaac tttacaagta gcatcaggaa agttctaaaa acatttcaga gttattaatt   4620

atccttattt catttaataa tgattatctt taatcagttt ttataagcaa attccattgt   4680

tcctcctatt ggaacgtaac actgtttaca cagcataatt gaagttgcag gggagacagg   4740

ctaaatctga cttcatctgt actcactttc actaagcatt gaatggcctt accactcttc   4800

tgcaagatgg aggaagaccg caaaacttag tgcccatcac actgaaggaa gggatgtggt   4860

tttttttcct gcttctgtac tgctacctaa ctttgtgatt tgctttggat tttaatattt   4920

gtttctgttt tagattcaag cccgtaagtt ttgaggtgac ttcagctcca ttgtgaaata   4980

gatagttctc ttcatatttc ataactacat ttcaataatt ctaaactttc tacattgatt   5040

tttagatact tatttttcaa gcttggtttc tcagctgatc agatgaattt attcaacttc   5100

aatacaaaga aagacaaacc tattatagtt tcaagtgagt agatattata ctgtacagga   5160

cagctatttg aacacacaca tcactgcttt agaaataaaa ccgccaattt ataaatgtat   5220

atgacctaca ttttatagga aaaaatgttt ttaaatgcta gtcatttata taatgtgctt   5280

tgaaggattt gctagtccac ttctgtcact ttttagtaca ctggtatctt ttatatgtaa   5340

tgtatgcttt ttattattgt agcaaagcat ttcagtagaa agaattttgc aacaatatgg   5400

gggaaatttt tcattgttgg atttgaatta tactggattt tatctgtgta gtcttacttg   5460

tctttatttt aatgctgtct gaagggaact tggtatccaa ataaagcagg taacctcatt   5520

ttacttcaag ggcatactgt gtagtgctga atttaatctg aaaatctgat gattttgaaa   5580

agaaaaacaa gtttataaac attgtacaga agaaattaaa tgtgtgtgat ggaaatcctg   5640

atggtggagc acgttgaatt ttctgatata tagtgttatt ttcctgggat cccctatgcc   5700

ttctttgtat ttcaactaat aaaggaaaaa ccctgtcatt aaaactggta agataatagg   5760

atattctgat tatacagtat tactattcct atcccatttt ctgacctttt ctcaatcact   5820

gtaaattttt attttctatt tcctattgat aattaaatat gtacataata tagacactgt   5880

tgtatagaac taaatgaatt gggttgctat gcttgagtgg gtagtgaaat ggaaatattt   5940

gatgaatact gagagttcct aaaatgctag agcaaatttc cgagggaaag gggggcatcg   6000

tgtgtcttgg gaaggttgca gcaggttgtt tcttcaactc cctaagaaat cattgggaag   6060

gactcaactg caaactcggg atcagataca aaatgggtct ttccttcccc tctcccccaa   6120

aaaataggag cactaaattt taaaatctac tcaggtgaca gttgctttgc aatgaaactt   6180

atcacattga aattttcagt gttaaataaa aagagatttg tgatattttt aaatataaac   6240

ttttacatca gtagtcagca gcctgacaat tgaaatttgg taagtcgata tattttaaaa   6300

tattttgctc tccaaataga attgttttta aacaattggg aggttttttg tttctttaaa   6360

tatgttttaa ttgtcattgt aaaaacaaaa tcttgcttga ccctatatta tgccatgaat   6420

gaattgctga gcctttataa tacagtgaca gcttgtttca tgcatagtca tggaacatag   6480

agatgttctt taaactgacc tattgataag aggtttaatg agtttcacgg ctttcaacac   6540

tattgtcata tagttatctt tgccatttgg agtttataaa accattttat gtattgtgat   6600

actaaaggaa gttgttttgc tttactttaa attgaattat tagactaata tttgcaaatt   6660

ctgcatttta aatgtggaca ctggctgttt gaaaaataaa atatagaata cagttttatg   6720

gataattttc gagctgaatt tttcacaata ttctgaacca aataacgaat ggtaaatatg   6780

caaaaatcat ggtgcataga tataaccgta aagagaaaag aatttctgtg tggaattaac   6840

agttacacaa attgggtaac aattatcagg gcctttatta tagctttatg tggaatgtta   6900

ttctaaaatg caagagtcaa atgttactgt cattgaatat tttagacttg aaacgtgttt   6960

atcatagagc gaagaaaata tgtgttcttt tctttacaga taagactctg ttaacccact   7020

gtcagcatac gtgggatttc ttttcttttt tctttcatta gtggagattt gttttcatcc   7080

atctaccacc ttgccagtac cctagcttgt gaccagcggg atgcattgta agaaagttgt   7140

ctgtggttag gagtgcagtc tgggtccatg gaacaaattt aaactaattg gccctcgcaa   7200

tgatcagtcc taggaccctg gccttattat tagcatggtg ctttaaccaa ttgtacataa   7260

taataccact gatagtctac taatgcattt cctagatccc agtttttctt gaatgattag   7320

gaatggtggg gagaggggag gggagatatt ctacatgata cttctccaat cttctaaaga   7380

ttataagaaa aaataaaaaa ttgaagtcac ttg                                7413


<210>  1745
<211>  144
<212>  PRT
<213>  Homo sapiens

<400>  1745


Met Lys Gly Glu Lys Pro Phe Gln Cys Ser Gln Cys Asp Met Arg Phe 
1               5                   10                  15      


Ile Gln Lys Tyr Leu Leu Gln Arg His Glu Lys Ile His Thr Gly Glu 
            20                  25                  30          


Lys Pro Phe Arg Cys Asp Glu Cys Gly Asp Glu Thr Asn His Ala Ser 
        35                  40                  45              


Ala Thr Ser Thr Gln Asp Phe Leu Asp Gln Val Thr Ser Gln Lys Lys 
    50                  55                  60                  


Ala Glu Ala Gln Pro Val His Gln Ala Tyr Gln Met Ser Ser Phe Glu 
65                  70                  75                  80  


Gln Pro Phe Arg Ala Pro Tyr His Gly Ser Arg Ala Gly Ile Ala Thr 
                85                  90                  95      


Gln Phe Ser Thr Ala Asn Gly Gln Val Asn Leu Arg Gly Pro Gly Thr 
            100                 105                 110         


Ser Ala Glu Phe Ser Glu Phe Pro Leu Val Asn Val Asn Asp Asn Arg 
        115                 120                 125             


Ala Gly Met Thr Ser Ser Pro Asp Ala Thr Thr Gly Gln Thr Phe Gly 
    130                 135                 140                 

<210>  1746
<211>  9658
<212>  DNA
<213>  Homo sapiens

<400>  1746
ggcgaccgcg gcggcgctct agctgcggca tgtctgcgtc tctactgctc tgggaggagg     60

aagagaagga ggaagaggag gaggaggagg agggggagga agaggagaaa ggcgcagggg    120

tgggagctgt tgccgaagct gccacagcaa aagttctccc ccctcccccc ttcccctcct    180

ctcaaggccc ctagaaaggt tggagctgcc gccgcctgca gtcggtgacc gcgcgactcg    240

gcgcccgccc gcggatagag ggaggaatca gcagcttgga aattcaagca cgtgatctgg    300

cgggatgggc gtttgcctaa cgtatttaat ggaggaatcg gatggcataa gtgattaagg    360

tggtattgag gatttctgaa gcctatgaaa ggtagaaact caaccatgat ttctttttca    420

actctacagc attcctttcc ttgaagtctt cgtttttacc ttagtctcgg ggtcttattc    480

tgtcacctag gtggagtgca gtagtacagt cacagctcac tgcagcccca acatcctggg    540

ctcaagccat cctcctgcct cagcctccca agtagctggg accacaggca gttatactta    600

agcatgaaca ttgacgacaa actggaagga ttgtttctta aatgtggcgg catagacgaa    660

atgcagtctt ccaggacaat ggttgtaatg ggtggagtgt ctggccagtc tactgtgtct    720

ggagagctac aggattcagt acttcaagat cgaagtatgc ctcaccagga gatccttgct    780

gcagatgaag tgttacaaga aagtgaaatg agacaacagg atatgatatc acatgatgaa    840

ctcatggtcc atgaggagac agtgaaaaat gatgaagagc agatggaaac acatgaaaga    900

cttcctcaag gactacagta tgcacttaat gtccctataa gcgtaaagca ggaaattact    960

tttactgatg tatctgagca actgatgaga gacaaaaaac aaatcagaga gccagtagac   1020

ttacagaaaa agaagaagcg gaaacaacgt tctcccgcaa aaatccttac aataaatgag   1080

gatggatcac ttggtttgaa aacccctaaa tctcacgttt gtgagcactg caatgctgcc   1140

tttagaacga actatcactt acagagacat gtcttcattc atacaggtga aaaaccattt   1200

caatgtagtc aatgtgacat gcgtttcata cagaagtacc tgcttcagag acatgagaag   1260

attcatactg gtgaaaaacc atttcgctgt gatgaatgtg gtatgagatt catacaaaaa   1320

tatcatatgg aaaggcataa gagaactcat agtggagaaa aaccttacca gtgtgaatac   1380

tgtttacagt atttttccag aacagatcgt gtattgaaac ataaacgtat gtgccatgaa   1440

aatcatgaca aaaaactaaa tagatgtgcc atcaaaggtg gccttctgac atctgaggaa   1500

gattctggct tttctacatc accaaaagac aactcactgc caaaaaagaa aaggcagaaa   1560

acggagaaaa aatcatctgg aatggacaaa gagagtgctt tggacaaatc tgacctgaaa   1620

aaagacaaaa atgattactt gcctctttat tcttcaagta ctaaagtaaa agatgagtat   1680

atggttgcag aatatgctgt tgaaatgcca cattcgtcag ttgggggctc gcatttagaa   1740

gatgcgtcag gagaaataca cccacctaag ttagttctca aaaaaattaa tagtaagaga   1800

agtctgaaac agccactgga gcaaaatcaa acaatttcac ctttatccac atatgaagag   1860

agcaaagttt caaagtatgc ttttgaactt gtggataaac aggctttact ggactcagaa   1920

ggcaatgctg acattgatca ggttgataat ttgcaggagg ggcccagtaa acctgtgcat   1980

agtagtacta attatgatga tgccatgcag tttttgaaga agaagcggta tcttcaagca   2040

gcaagtaaca acagcaggga atatgcgctg aatgtgggta ccatagcttc tcagccttct   2100

gtaacacaag cagctgtggc aagtgtcatt gatgaaagta ccacggcatc catattagag   2160

tcacaggcac tgaatgtgga gattaagagt aatcatgaca aaaatgttat tccagatgag   2220

gtactgcaga ctctgttgga tcattattcc cacaaagcta atggacagca tgagatatcc   2280

ttcagtgttg cagatactga agtgacttct agcatatcaa taaattcttc agaagtacca   2340

gaggtcaccc cgtcagagaa tgttggatca agctcccaag catcctcatc agataaagcc   2400

aacatgttgc aggaatactc caagtttctg cagcaggctt tggacagaac tagccaaaat   2460

gatgcctatt tgaatagccc gagccttaac tttgtgactg ataaccagac cctcccaaat   2520

cagccagcat tctcttccat agacaagcag gtctatgcca ccatgcccat caatagcttt   2580

cgatcaggaa tgaattctcc actaagaaca actccagata agtcccactt tggactaata   2640

gttggtgatt cacagcactc atttcccttt tcaggtgatg agacaaacca tgcttctgcc   2700

acatcaacac aggactttct ggatcaagtg acttctcaga agaaagctga ggcccagcct   2760

gtccaccaag cttaccaaat gagctccttt gaacagccct tccgtgctcc ctatcatgga   2820

tcaagagctg gaatagctac tcaatttagc actgccaatg gacaggtgaa ccttcgggga   2880

ccagggacaa gtgctgaatt ttcagaattt cccttggtga atgtaaatga taatagagct   2940

gggatgacat cttcacctga tgccacaact ggccagactt ttggctaaaa aaaaaaaaaa   3000

agtgtaaata atactggcac tttagaacag attaatcaag agtggggtta ctctgtgtaa   3060

atggagtgct gtacagattt aagagcaatg cgtaataaca agttaagctg atatgaatag   3120

caagataatc caataactgc atttcgtttg gttagtcagc attctttgaa ctgccttaca   3180

tgttgtcacc tttatagaag caatgcatta cttgttttag atcagaaact tgctattcca   3240

cccacaccaa gttaaaaagg aaaaaaaaaa gactttcgca caattgtttc ctaactgata   3300

acattgtaca ttcttaggag attagtaatt gtgtgaaatt tactcatact gtttctaagt   3360

ttttcagcat agtcattgca cttcagcagg gaatctgagt atactttaca gacagagtga   3420

acttaaaagt ttaatgtcaa gagattatgg cttaaataaa ttagtgtgtc ctataggggg   3480

aaaaaaacca agaaaccacc ttttaaaaag aatgatatgc catataccct tgattttcat   3540

tttgcattat attgacgtgt ttttttgaag gaaaaaaagt aataaaaatc tgatagtcta   3600

agactccact atttaaaagc ctaattactt taaaaatatg catactttca gaacttttac   3660

caaaacacac aactgttgaa gcagtcactt ctctatggaa gtatgcatat tggtgtcagt   3720

ttctttgtac agttgtactt agatattttt tatgattttt catgtgcagg tatcaaggtt   3780

ttgaagtttt agtaaaagaa attctgtaga ttacattccc aagaacataa tgcttacaca   3840

aaatgtatat tccacgtttt aaagcttaat tgtattttac tttacatata cacttcagtt   3900

aacatagagc acttagaatc tatttggtat ttttgatttc tcaaagtaaa aaaaaaatta   3960

gatttttagg tttgatatgg ttgtgtcata atcatctcgt aattgacaat tttaactttt   4020

ggcaataaaa ggaaattggg atatctttgg aactgtaaaa cctggtttaa tctttttctt   4080

tctagactct tgatagattg gataattaaa cagtatccag agaaactaaa gaaatgggca   4140

ttttaattgc atattttatc ttgagttact ttttaatgaa cactgctcat tacaacttta   4200

caaaccaaaa gtgtttacta attccagtaa ctaccatttc tttttcagct agatgagtga   4260

tcggaaaatt tttgttgcat ttcaaaatct aaataaacta cagactttat ccttatacca   4320

tgaatgtttt tttttaatac tctgtcttaa aataatacag catggtacaa taaatagtgc   4380

ttttatgtat atatacacac acacactttt ctgaagaatg atggtttgag ttatgcgttg   4440

ggcagttttg atttttggaa gttatattag ttattgactc tttgttacaa ctttttcatt   4500

tttacatttt aaattttctg ccatcgttgt cacaatgcac atcctgatat agcaccagtg   4560

aaaatctaaa attaataccc ttggaaaatg aaaatattct taatttccat tttgactctt   4620

atactggccc tatagctctg cagtctttgt ttcaatatag aatatgttat ccatttaaat   4680

tattttttct tttatttaat gttatcccaa gactgttctc ataaagaaag ggaagaaata   4740

actatccacc cttaacatcc ttcatttatt ttgaatatat tggtgttttt atgataagga   4800

atataaatta tatttaatgt ggtttcctgt atactttggt tattaagttt tgcttgaaat   4860

agtagttttc ccgtttgaca gctttctttg ctgccaaagt tttcaagaat ttaagacttc   4920

tttgaagtaa atatttaagt tctgccatta ttgactctta agattgtgtg tgttgtgttg   4980

tgcattacat aattacaaaa aggcttcatt caggtgatac gttaaaaatg gaactgtgct   5040

caccctaaat aggcattggt atttttctct tttggtgaga gtaggcattt atttcttgag   5100

ttgttttgga gcctgatcaa aaattttgtt catggagaac ttgatgcaat tttgatacag   5160

tggagaggtt tttttcggtt gttttaacat caccagcata gtttttagaa tgtgactctt   5220

gctgagcatt tagggtgagc ttgggaagga aggcctttga aaatggtagt tatgcaagca   5280

gactttcagg tgttgcattc ctgttttcaa cacatttctt taaatctaca taatggcaga   5340

cttttctacc aggttataag cagtttttag ataagtgata ctcagccagc ataacttatt   5400

gacttaccat ttacgtatag tcatcactct cttactgtga aattccaaat gcctaccaga   5460

gttaccttgt tctatcataa tatgacaaac atctcaacag ttttggattt ccccactttg   5520

gttcagaagg ttatttaatt tctatctggg cattaatgga gaaaataagt agccttgtgt   5580

gctgcttcag attgaaacat ggaggatatg agatattctt ctgcaattca tgtttctcat   5640

ttctcaaagt gagcacattg ttctataaaa acatgctggt acacccttaa acttttgatc   5700

aatctgagtg aggtgtgctt ttcctcttgg gacctactca cgtttgaaga ttggaaacat   5760

cacgttaggc gaggcagtat ctcttgaaca tcttctaaag ggttttttaa aaccttattc   5820

tcacatattt catttgtctt gaatatttaa gtggctctta aacgttttgg gtctacatgc   5880

aaatgtggta cttaacaagg taggaatcca tcttcttagc tctggctgag ggtgccagcc   5940

atcggtcagg tcatttttat ctcaagaggc agaaggcagt tatgtcaaga attgtgctca   6000

gggcaggatt tcgtttccac agaggagaga cacttgcaga gtgccagcta ggttagatct   6060

tttgccgctt ctttcatttg attaatttgg gtttttaaag ggctgtttaa aaaaaaaaaa   6120

aaaaggccgg gaaactttaa aagtaggcat tactgtagta ctgcatttct tagaacattt   6180

taaactagaa ctcatttttt tttcacagta tatttacttg aagaagcact ataataatca   6240

ttgagaagta ttttgagtct gaaatttaat ttaattttcc gtttcaaatt gctttatttc   6300

agggaaataa ttttccagtt gttttgctat attctgcaaa taaaaaccgt gtttcctttt   6360

ttcacttaaa ctttggtagg aaacaaacta aagcagacaa acatttcttg ttatgtttgt   6420

tgctttcttt aatccaatgg ataaaaaagt aaaaccctgt aaacattatt ttattttttt   6480

atgcaatacc atgctgtaaa tatggttcat caaataagga tgtacctatg attgaatctt   6540

taattctgca cagttagagt ttatatataa acgtgtcttg acaatcaagg acttttatgt   6600

gagtcttcct ttatgatgtt tattaatgtt atgcattcca tttgttttga agtgagtacc   6660

aatgtgctaa tttgtattgt ctgaaagtat gtaatgtttt tacagcttgt ttttaagaat   6720

ctgtaaatat gtacaaacaa atcacagtac tgctttatgt tagaaggcat atgatgttgt   6780

actgtatgta agcaataata catagcagtg ctaactttac aagtagcatc aggaaagttc   6840

taaaaacatt tcagagttat taattatcct tatttcattt aataatgatt atctttaatc   6900

agtttttata agcaaattcc attgttcctc ctattggaac gtaacactgt ttacacagca   6960

taattgaagt tgcaggggag acaggctaaa tctgacttca tctgtactca ctttcactaa   7020

gcattgaatg gccttaccac tcttctgcaa gatggaggaa gaccgcaaaa cttagtgccc   7080

atcacactga aggaagggat gtggtttttt ttcctgcttc tgtactgcta cctaactttg   7140

tgatttgctt tggattttaa tatttgtttc tgttttagat tcaagcccgt aagttttgag   7200

gtgacttcag ctccattgtg aaatagatag ttctcttcat atttcataac tacatttcaa   7260

taattctaaa ctttctacat tgatttttag atacttattt ttcaagcttg gtttctcagc   7320

tgatcagatg aatttattca acttcaatac aaagaaagac aaacctatta tagtttcaag   7380

tgagtagata ttatactgta caggacagct atttgaacac acacatcact gctttagaaa   7440

taaaaccgcc aatttataaa tgtatatgac ctacatttta taggaaaaaa tgtttttaaa   7500

tgctagtcat ttatataatg tgctttgaag gatttgctag tccacttctg tcacttttta   7560

gtacactggt atcttttata tgtaatgtat gctttttatt attgtagcaa agcatttcag   7620

tagaaagaat tttgcaacaa tatgggggaa atttttcatt gttggatttg aattatactg   7680

gattttatct gtgtagtctt acttgtcttt attttaatgc tgtctgaagg gaacttggta   7740

tccaaataaa gcaggtaacc tcattttact tcaagggcat actgtgtagt gctgaattta   7800

atctgaaaat ctgatgattt tgaaaagaaa aacaagttta taaacattgt acagaagaaa   7860

ttaaatgtgt gtgatggaaa tcctgatggt ggagcacgtt gaattttctg atatatagtg   7920

ttattttcct gggatcccct atgccttctt tgtatttcaa ctaataaagg aaaaaccctg   7980

tcattaaaac tggtaagata ataggatatt ctgattatac agtattacta ttcctatccc   8040

attttctgac cttttctcaa tcactgtaaa tttttatttt ctatttccta ttgataatta   8100

aatatgtaca taatatagac actgttgtat agaactaaat gaattgggtt gctatgcttg   8160

agtgggtagt gaaatggaaa tatttgatga atactgagag ttcctaaaat gctagagcaa   8220

atttccgagg gaaagggggg catcgtgtgt cttgggaagg ttgcagcagg ttgtttcttc   8280

aactccctaa gaaatcattg ggaaggactc aactgcaaac tcgggatcag atacaaaatg   8340

ggtctttcct tcccctctcc cccaaaaaat aggagcacta aattttaaaa tctactcagg   8400

tgacagttgc tttgcaatga aacttatcac attgaaattt tcagtgttaa ataaaaagag   8460

atttgtgata tttttaaata taaactttta catcagtagt cagcagcctg acaattgaaa   8520

tttggtaagt cgatatattt taaaatattt tgctctccaa atagaattgt ttttaaacaa   8580

ttgggaggtt ttttgtttct ttaaatatgt tttaattgtc attgtaaaaa caaaatcttg   8640

cttgacccta tattatgcca tgaatgaatt gctgagcctt tataatacag tgacagcttg   8700

tttcatgcat agtcatggaa catagagatg ttctttaaac tgacctattg ataagaggtt   8760

taatgagttt cacggctttc aacactattg tcatatagtt atctttgcca tttggagttt   8820

ataaaaccat tttatgtatt gtgatactaa aggaagttgt tttgctttac tttaaattga   8880

attattagac taatatttgc aaattctgca ttttaaatgt ggacactggc tgtttgaaaa   8940

ataaaatata gaatacagtt ttatggataa ttttcgagct gaatttttca caatattctg   9000

aaccaaataa cgaatggtaa atatgcaaaa atcatggtgc atagatataa ccgtaaagag   9060

aaaagaattt ctgtgtggaa ttaacagtta cacaaattgg gtaacaatta tcagggcctt   9120

tattatagct ttatgtggaa tgttattcta aaatgcaaga gtcaaatgtt actgtcattg   9180

aatattttag acttgaaacg tgtttatcat agagcgaaga aaatatgtgt tcttttcttt   9240

acagataaga ctctgttaac ccactgtcag catacgtggg atttcttttc ttttttcttt   9300

cattagtgga gatttgtttt catccatcta ccaccttgcc agtaccctag cttgtgacca   9360

gcgggatgca ttgtaagaaa gttgtctgtg gttaggagtg cagtctgggt ccatggaaca   9420

aatttaaact aattggccct cgcaatgatc agtcctagga ccctggcctt attattagca   9480

tggtgcttta accaattgta cataataata ccactgatag tctactaatg catttcctag   9540

atcccagttt ttcttgaatg attaggaatg gtggggagag gggaggggag atattctaca   9600

tgatacttct ccaatcttct aaagattata agaaaaaata aaaaattgaa gtcacttg     9658


<210>  1747
<211>  794
<212>  PRT
<213>  Homo sapiens

<400>  1747


Met Asn Ile Asp Asp Lys Leu Glu Gly Leu Phe Leu Lys Cys Gly Gly 
1               5                   10                  15      


Ile Asp Glu Met Gln Ser Ser Arg Thr Met Val Val Met Gly Gly Val 
            20                  25                  30          


Ser Gly Gln Ser Thr Val Ser Gly Glu Leu Gln Asp Ser Val Leu Gln 
        35                  40                  45              


Asp Arg Ser Met Pro His Gln Glu Ile Leu Ala Ala Asp Glu Val Leu 
    50                  55                  60                  


Gln Glu Ser Glu Met Arg Gln Gln Asp Met Ile Ser His Asp Glu Leu 
65                  70                  75                  80  


Met Val His Glu Glu Thr Val Lys Asn Asp Glu Glu Gln Met Glu Thr 
                85                  90                  95      


His Glu Arg Leu Pro Gln Gly Leu Gln Tyr Ala Leu Asn Val Pro Ile 
            100                 105                 110         


Ser Val Lys Gln Glu Ile Thr Phe Thr Asp Val Ser Glu Gln Leu Met 
        115                 120                 125             


Arg Asp Lys Lys Gln Ile Arg Glu Pro Val Asp Leu Gln Lys Lys Lys 
    130                 135                 140                 


Lys Arg Lys Gln Arg Ser Pro Ala Lys Ile Leu Thr Ile Asn Glu Asp 
145                 150                 155                 160 


Gly Ser Leu Gly Leu Lys Thr Pro Lys Ser His Val Cys Glu His Cys 
                165                 170                 175     


Asn Ala Ala Phe Arg Thr Asn Tyr His Leu Gln Arg His Val Phe Ile 
            180                 185                 190         


His Thr Gly Glu Lys Pro Phe Gln Cys Ser Gln Cys Asp Met Arg Phe 
        195                 200                 205             


Ile Gln Lys Tyr Leu Leu Gln Arg His Glu Lys Ile His Thr Gly Glu 
    210                 215                 220                 


Lys Pro Phe Arg Cys Asp Glu Cys Gly Met Arg Phe Ile Gln Lys Tyr 
225                 230                 235                 240 


His Met Glu Arg His Lys Arg Thr His Ser Gly Glu Lys Pro Tyr Gln 
                245                 250                 255     


Cys Glu Tyr Cys Leu Gln Tyr Phe Ser Arg Thr Asp Arg Val Leu Lys 
            260                 265                 270         


His Lys Arg Met Cys His Glu Asn His Asp Lys Lys Leu Asn Arg Cys 
        275                 280                 285             


Ala Ile Lys Gly Gly Leu Leu Thr Ser Glu Glu Asp Ser Gly Phe Ser 
    290                 295                 300                 


Thr Ser Pro Lys Asp Asn Ser Leu Pro Lys Lys Lys Arg Gln Lys Thr 
305                 310                 315                 320 


Glu Lys Lys Ser Ser Gly Met Asp Lys Glu Ser Ala Leu Asp Lys Ser 
                325                 330                 335     


Asp Leu Lys Lys Asp Lys Asn Asp Tyr Leu Pro Leu Tyr Ser Ser Ser 
            340                 345                 350         


Thr Lys Val Lys Asp Glu Tyr Met Val Ala Glu Tyr Ala Val Glu Met 
        355                 360                 365             


Pro His Ser Ser Val Gly Gly Ser His Leu Glu Asp Ala Ser Gly Glu 
    370                 375                 380                 


Ile His Pro Pro Lys Leu Val Leu Lys Lys Ile Asn Ser Lys Arg Ser 
385                 390                 395                 400 


Leu Lys Gln Pro Leu Glu Gln Asn Gln Thr Ile Ser Pro Leu Ser Thr 
                405                 410                 415     


Tyr Glu Glu Ser Lys Val Ser Lys Tyr Ala Phe Glu Leu Val Asp Lys 
            420                 425                 430         


Gln Ala Leu Leu Asp Ser Glu Gly Asn Ala Asp Ile Asp Gln Val Asp 
        435                 440                 445             


Asn Leu Gln Glu Gly Pro Ser Lys Pro Val His Ser Ser Thr Asn Tyr 
    450                 455                 460                 


Asp Asp Ala Met Gln Phe Leu Lys Lys Lys Arg Tyr Leu Gln Ala Ala 
465                 470                 475                 480 


Ser Asn Asn Ser Arg Glu Tyr Ala Leu Asn Val Gly Thr Ile Ala Ser 
                485                 490                 495     


Gln Pro Ser Val Thr Gln Ala Ala Val Ala Ser Val Ile Asp Glu Ser 
            500                 505                 510         


Thr Thr Ala Ser Ile Leu Glu Ser Gln Ala Leu Asn Val Glu Ile Lys 
        515                 520                 525             


Ser Asn His Asp Lys Asn Val Ile Pro Asp Glu Val Leu Gln Thr Leu 
    530                 535                 540                 


Leu Asp His Tyr Ser His Lys Ala Asn Gly Gln His Glu Ile Ser Phe 
545                 550                 555                 560 


Ser Val Ala Asp Thr Glu Val Thr Ser Ser Ile Ser Ile Asn Ser Ser 
                565                 570                 575     


Glu Val Pro Glu Val Thr Pro Ser Glu Asn Val Gly Ser Ser Ser Gln 
            580                 585                 590         


Ala Ser Ser Ser Asp Lys Ala Asn Met Leu Gln Glu Tyr Ser Lys Phe 
        595                 600                 605             


Leu Gln Gln Ala Leu Asp Arg Thr Ser Gln Asn Asp Ala Tyr Leu Asn 
    610                 615                 620                 


Ser Pro Ser Leu Asn Phe Val Thr Asp Asn Gln Thr Leu Pro Asn Gln 
625                 630                 635                 640 


Pro Ala Phe Ser Ser Ile Asp Lys Gln Val Tyr Ala Thr Met Pro Ile 
                645                 650                 655     


Asn Ser Phe Arg Ser Gly Met Asn Ser Pro Leu Arg Thr Thr Pro Asp 
            660                 665                 670         


Lys Ser His Phe Gly Leu Ile Val Gly Asp Ser Gln His Ser Phe Pro 
        675                 680                 685             


Phe Ser Gly Asp Glu Thr Asn His Ala Ser Ala Thr Ser Thr Gln Asp 
    690                 695                 700                 


Phe Leu Asp Gln Val Thr Ser Gln Lys Lys Ala Glu Ala Gln Pro Val 
705                 710                 715                 720 


His Gln Ala Tyr Gln Met Ser Ser Phe Glu Gln Pro Phe Arg Ala Pro 
                725                 730                 735     


Tyr His Gly Ser Arg Ala Gly Ile Ala Thr Gln Phe Ser Thr Ala Asn 
            740                 745                 750         


Gly Gln Val Asn Leu Arg Gly Pro Gly Thr Ser Ala Glu Phe Ser Glu 
        755                 760                 765             


Phe Pro Leu Val Asn Val Asn Asp Asn Arg Ala Gly Met Thr Ser Ser 
    770                 775                 780                 


Pro Asp Ala Thr Thr Gly Gln Thr Phe Gly 
785                 790                 

<210>  1748
<211>  9541
<212>  DNA
<213>  Homo sapiens

<400>  1748
ggcgaccgcg gcggcgctct agctgcggca tgtctgcgtc tctactgctc tgggaggagg     60

aagagaagga ggaagaggag gaggaggagg agggggagga agaggagaaa ggcgcagggg    120

tgggagctgt tgccgaagct gccacagcaa aagttctccc ccctcccccc ttcccctcct    180

ctcaaggccc ctagaaaggt tggagctgcc gccgcctgca gtcggtgacc gcgcgactcg    240

gcgcccgccc gcggatagag ggaggaatca gcagcttgga aattcaagca cgtgatctgg    300

cgggatgggc gtttgcctaa cgtatttaat ggaggaatcg gatggcataa gtgattaagg    360

tggtattgag gatttctgaa gcctatgaaa ggtagaaact caaccatgat ttctttttca    420

actctacagc attcctttcc ttgaagtctt cgtttttacc ttagtctcgg gcagttatac    480

ttaagcatga acattgacga caaactggaa ggattgtttc ttaaatgtgg cggcatagac    540

gaaatgcagt cttccaggac aatggttgta atgggtggag tgtctggcca gtctactgtg    600

tctggagagc tacaggattc agtacttcaa gatcgaagta tgcctcacca ggagatcctt    660

gctgcagatg aagtgttaca agaaagtgaa atgagacaac aggatatgat atcacatgat    720

gaactcatgg tccatgagga gacagtgaaa aatgatgaag agcagatgga aacacatgaa    780

agacttcctc aaggactaca gtatgcactt aatgtcccta taagcgtaaa gcaggaaatt    840

acttttactg atgtatctga gcaactgatg agagacaaaa aacaaatcag agagccagta    900

gacttacaga aaaagaagaa gcggaaacaa cgttctcccg caaaaatcct tacaataaat    960

gaggatggat cacttggttt gaaaacccct aaatctcacg tttgtgagca ctgcaatgct   1020

gcctttagaa cgaactatca cttacagaga catgtcttca ttcatacagg tgaaaaacca   1080

tttcaatgta gtcaatgtga catgcgtttc atacagaagt acctgcttca gagacatgag   1140

aagattcata ctggtgaaaa accatttcgc tgtgatgaat gtggtatgag attcatacaa   1200

aaatatcata tggaaaggca taagagaact catagtggag aaaaacctta ccagtgtgaa   1260

tactgtttac agtatttttc cagaacagat cgtgtattga aacataaacg tatgtgccat   1320

gaaaatcatg acaaaaaact aaatagatgt gccatcaaag gtggccttct gacatctgag   1380

gaagattctg gcttttctac atcaccaaaa gacaactcac tgccaaaaaa gaaaaggcag   1440

aaaacggaga aaaaatcatc tggaatggac aaagagagtg ctttggacaa atctgacctg   1500

aaaaaagaca aaaatgatta cttgcctctt tattcttcaa gtactaaagt aaaagatgag   1560

tatatggttg cagaatatgc tgttgaaatg ccacattcgt cagttggggg ctcgcattta   1620

gaagatgcgt caggagaaat acacccacct aagttagttc tcaaaaaaat taatagtaag   1680

agaagtctga aacagccact ggagcaaaat caaacaattt cacctttatc cacatatgaa   1740

gagagcaaag tttcaaagta tgcttttgaa cttgtggata aacaggcttt actggactca   1800

gaaggcaatg ctgacattga tcaggttgat aatttgcagg aggggcccag taaacctgtg   1860

catagtagta ctaattatga tgatgccatg cagtttttga agaagaagcg gtatcttcaa   1920

gcagcaagta acaacagcag ggaatatgcg ctgaatgtgg gtaccatagc ttctcagcct   1980

tctgtaacac aagcagctgt ggcaagtgtc attgatgaaa gtaccacggc atccatatta   2040

gagtcacagg cactgaatgt ggagattaag agtaatcatg acaaaaatgt tattccagat   2100

gaggtactgc agactctgtt ggatcattat tcccacaaag ctaatggaca gcatgagata   2160

tccttcagtg ttgcagatac tgaagtgact tctagcatat caataaattc ttcagaagta   2220

ccagaggtca ccccgtcaga gaatgttgga tcaagctccc aagcatcctc atcagataaa   2280

gccaacatgt tgcaggaata ctccaagttt ctgcagcagg ctttggacag aactagccaa   2340

aatgatgcct atttgaatag cccgagcctt aactttgtga ctgataacca gaccctccca   2400

aatcagccag cattctcttc catagacaag caggtctatg ccaccatgcc catcaatagc   2460

tttcgatcag gaatgaattc tccactaaga acaactccag ataagtccca ctttggacta   2520

atagttggtg attcacagca ctcatttccc ttttcaggtg atgagacaaa ccatgcttct   2580

gccacatcaa cacaggactt tctggatcaa gtgacttctc agaagaaagc tgaggcccag   2640

cctgtccacc aagcttacca aatgagctcc tttgaacagc ccttccgtgc tccctatcat   2700

ggatcaagag ctggaatagc tactcaattt agcactgcca atggacaggt gaaccttcgg   2760

ggaccaggga caagtgctga attttcagaa tttcccttgg tgaatgtaaa tgataataga   2820

gctgggatga catcttcacc tgatgccaca actggccaga cttttggcta aaaaaaaaaa   2880

aaaagtgtaa ataatactgg cactttagaa cagattaatc aagagtgggg ttactctgtg   2940

taaatggagt gctgtacaga tttaagagca atgcgtaata acaagttaag ctgatatgaa   3000

tagcaagata atccaataac tgcatttcgt ttggttagtc agcattcttt gaactgcctt   3060

acatgttgtc acctttatag aagcaatgca ttacttgttt tagatcagaa acttgctatt   3120

ccacccacac caagttaaaa aggaaaaaaa aaagactttc gcacaattgt ttcctaactg   3180

ataacattgt acattcttag gagattagta attgtgtgaa atttactcat actgtttcta   3240

agtttttcag catagtcatt gcacttcagc agggaatctg agtatacttt acagacagag   3300

tgaacttaaa agtttaatgt caagagatta tggcttaaat aaattagtgt gtcctatagg   3360

gggaaaaaaa ccaagaaacc accttttaaa aagaatgata tgccatatac ccttgatttt   3420

cattttgcat tatattgacg tgtttttttg aaggaaaaaa agtaataaaa atctgatagt   3480

ctaagactcc actatttaaa agcctaatta ctttaaaaat atgcatactt tcagaacttt   3540

taccaaaaca cacaactgtt gaagcagtca cttctctatg gaagtatgca tattggtgtc   3600

agtttctttg tacagttgta cttagatatt ttttatgatt tttcatgtgc aggtatcaag   3660

gttttgaagt tttagtaaaa gaaattctgt agattacatt cccaagaaca taatgcttac   3720

acaaaatgta tattccacgt tttaaagctt aattgtattt tactttacat atacacttca   3780

gttaacatag agcacttaga atctatttgg tatttttgat ttctcaaagt aaaaaaaaaa   3840

ttagattttt aggtttgata tggttgtgtc ataatcatct cgtaattgac aattttaact   3900

tttggcaata aaaggaaatt gggatatctt tggaactgta aaacctggtt taatcttttt   3960

ctttctagac tcttgataga ttggataatt aaacagtatc cagagaaact aaagaaatgg   4020

gcattttaat tgcatatttt atcttgagtt actttttaat gaacactgct cattacaact   4080

ttacaaacca aaagtgttta ctaattccag taactaccat ttctttttca gctagatgag   4140

tgatcggaaa atttttgttg catttcaaaa tctaaataaa ctacagactt tatccttata   4200

ccatgaatgt ttttttttaa tactctgtct taaaataata cagcatggta caataaatag   4260

tgcttttatg tatatataca cacacacact tttctgaaga atgatggttt gagttatgcg   4320

ttgggcagtt ttgatttttg gaagttatat tagttattga ctctttgtta caactttttc   4380

atttttacat tttaaatttt ctgccatcgt tgtcacaatg cacatcctga tatagcacca   4440

gtgaaaatct aaaattaata cccttggaaa atgaaaatat tcttaatttc cattttgact   4500

cttatactgg ccctatagct ctgcagtctt tgtttcaata tagaatatgt tatccattta   4560

aattattttt tcttttattt aatgttatcc caagactgtt ctcataaaga aagggaagaa   4620

ataactatcc acccttaaca tccttcattt attttgaata tattggtgtt tttatgataa   4680

ggaatataaa ttatatttaa tgtggtttcc tgtatacttt ggttattaag ttttgcttga   4740

aatagtagtt ttcccgtttg acagctttct ttgctgccaa agttttcaag aatttaagac   4800

ttctttgaag taaatattta agttctgcca ttattgactc ttaagattgt gtgtgttgtg   4860

ttgtgcatta cataattaca aaaaggcttc attcaggtga tacgttaaaa atggaactgt   4920

gctcacccta aataggcatt ggtatttttc tcttttggtg agagtaggca tttatttctt   4980

gagttgtttt ggagcctgat caaaaatttt gttcatggag aacttgatgc aattttgata   5040

cagtggagag gtttttttcg gttgttttaa catcaccagc atagttttta gaatgtgact   5100

cttgctgagc atttagggtg agcttgggaa ggaaggcctt tgaaaatggt agttatgcaa   5160

gcagactttc aggtgttgca ttcctgtttt caacacattt ctttaaatct acataatggc   5220

agacttttct accaggttat aagcagtttt tagataagtg atactcagcc agcataactt   5280

attgacttac catttacgta tagtcatcac tctcttactg tgaaattcca aatgcctacc   5340

agagttacct tgttctatca taatatgaca aacatctcaa cagttttgga tttccccact   5400

ttggttcaga aggttattta atttctatct gggcattaat ggagaaaata agtagccttg   5460

tgtgctgctt cagattgaaa catggaggat atgagatatt cttctgcaat tcatgtttct   5520

catttctcaa agtgagcaca ttgttctata aaaacatgct ggtacaccct taaacttttg   5580

atcaatctga gtgaggtgtg cttttcctct tgggacctac tcacgtttga agattggaaa   5640

catcacgtta ggcgaggcag tatctcttga acatcttcta aagggttttt taaaacctta   5700

ttctcacata tttcatttgt cttgaatatt taagtggctc ttaaacgttt tgggtctaca   5760

tgcaaatgtg gtacttaaca aggtaggaat ccatcttctt agctctggct gagggtgcca   5820

gccatcggtc aggtcatttt tatctcaaga ggcagaaggc agttatgtca agaattgtgc   5880

tcagggcagg atttcgtttc cacagaggag agacacttgc agagtgccag ctaggttaga   5940

tcttttgccg cttctttcat ttgattaatt tgggttttta aagggctgtt taaaaaaaaa   6000

aaaaaaaggc cgggaaactt taaaagtagg cattactgta gtactgcatt tcttagaaca   6060

ttttaaacta gaactcattt ttttttcaca gtatatttac ttgaagaagc actataataa   6120

tcattgagaa gtattttgag tctgaaattt aatttaattt tccgtttcaa attgctttat   6180

ttcagggaaa taattttcca gttgttttgc tatattctgc aaataaaaac cgtgtttcct   6240

tttttcactt aaactttggt aggaaacaaa ctaaagcaga caaacatttc ttgttatgtt   6300

tgttgctttc tttaatccaa tggataaaaa agtaaaaccc tgtaaacatt attttatttt   6360

tttatgcaat accatgctgt aaatatggtt catcaaataa ggatgtacct atgattgaat   6420

ctttaattct gcacagttag agtttatata taaacgtgtc ttgacaatca aggactttta   6480

tgtgagtctt cctttatgat gtttattaat gttatgcatt ccatttgttt tgaagtgagt   6540

accaatgtgc taatttgtat tgtctgaaag tatgtaatgt ttttacagct tgtttttaag   6600

aatctgtaaa tatgtacaaa caaatcacag tactgcttta tgttagaagg catatgatgt   6660

tgtactgtat gtaagcaata atacatagca gtgctaactt tacaagtagc atcaggaaag   6720

ttctaaaaac atttcagagt tattaattat ccttatttca tttaataatg attatcttta   6780

atcagttttt ataagcaaat tccattgttc ctcctattgg aacgtaacac tgtttacaca   6840

gcataattga agttgcaggg gagacaggct aaatctgact tcatctgtac tcactttcac   6900

taagcattga atggccttac cactcttctg caagatggag gaagaccgca aaacttagtg   6960

cccatcacac tgaaggaagg gatgtggttt tttttcctgc ttctgtactg ctacctaact   7020

ttgtgatttg ctttggattt taatatttgt ttctgtttta gattcaagcc cgtaagtttt   7080

gaggtgactt cagctccatt gtgaaataga tagttctctt catatttcat aactacattt   7140

caataattct aaactttcta cattgatttt tagatactta tttttcaagc ttggtttctc   7200

agctgatcag atgaatttat tcaacttcaa tacaaagaaa gacaaaccta ttatagtttc   7260

aagtgagtag atattatact gtacaggaca gctatttgaa cacacacatc actgctttag   7320

aaataaaacc gccaatttat aaatgtatat gacctacatt ttataggaaa aaatgttttt   7380

aaatgctagt catttatata atgtgctttg aaggatttgc tagtccactt ctgtcacttt   7440

ttagtacact ggtatctttt atatgtaatg tatgcttttt attattgtag caaagcattt   7500

cagtagaaag aattttgcaa caatatgggg gaaatttttc attgttggat ttgaattata   7560

ctggatttta tctgtgtagt cttacttgtc tttattttaa tgctgtctga agggaacttg   7620

gtatccaaat aaagcaggta acctcatttt acttcaaggg catactgtgt agtgctgaat   7680

ttaatctgaa aatctgatga ttttgaaaag aaaaacaagt ttataaacat tgtacagaag   7740

aaattaaatg tgtgtgatgg aaatcctgat ggtggagcac gttgaatttt ctgatatata   7800

gtgttatttt cctgggatcc cctatgcctt ctttgtattt caactaataa aggaaaaacc   7860

ctgtcattaa aactggtaag ataataggat attctgatta tacagtatta ctattcctat   7920

cccattttct gaccttttct caatcactgt aaatttttat tttctatttc ctattgataa   7980

ttaaatatgt acataatata gacactgttg tatagaacta aatgaattgg gttgctatgc   8040

ttgagtgggt agtgaaatgg aaatatttga tgaatactga gagttcctaa aatgctagag   8100

caaatttccg agggaaaggg gggcatcgtg tgtcttggga aggttgcagc aggttgtttc   8160

ttcaactccc taagaaatca ttgggaagga ctcaactgca aactcgggat cagatacaaa   8220

atgggtcttt ccttcccctc tcccccaaaa aataggagca ctaaatttta aaatctactc   8280

aggtgacagt tgctttgcaa tgaaacttat cacattgaaa ttttcagtgt taaataaaaa   8340

gagatttgtg atatttttaa atataaactt ttacatcagt agtcagcagc ctgacaattg   8400

aaatttggta agtcgatata ttttaaaata ttttgctctc caaatagaat tgtttttaaa   8460

caattgggag gttttttgtt tctttaaata tgttttaatt gtcattgtaa aaacaaaatc   8520

ttgcttgacc ctatattatg ccatgaatga attgctgagc ctttataata cagtgacagc   8580

ttgtttcatg catagtcatg gaacatagag atgttcttta aactgaccta ttgataagag   8640

gtttaatgag tttcacggct ttcaacacta ttgtcatata gttatctttg ccatttggag   8700

tttataaaac cattttatgt attgtgatac taaaggaagt tgttttgctt tactttaaat   8760

tgaattatta gactaatatt tgcaaattct gcattttaaa tgtggacact ggctgtttga   8820

aaaataaaat atagaataca gttttatgga taattttcga gctgaatttt tcacaatatt   8880

ctgaaccaaa taacgaatgg taaatatgca aaaatcatgg tgcatagata taaccgtaaa   8940

gagaaaagaa tttctgtgtg gaattaacag ttacacaaat tgggtaacaa ttatcagggc   9000

ctttattata gctttatgtg gaatgttatt ctaaaatgca agagtcaaat gttactgtca   9060

ttgaatattt tagacttgaa acgtgtttat catagagcga agaaaatatg tgttcttttc   9120

tttacagata agactctgtt aacccactgt cagcatacgt gggatttctt ttcttttttc   9180

tttcattagt ggagatttgt tttcatccat ctaccacctt gccagtaccc tagcttgtga   9240

ccagcgggat gcattgtaag aaagttgtct gtggttagga gtgcagtctg ggtccatgga   9300

acaaatttaa actaattggc cctcgcaatg atcagtccta ggaccctggc cttattatta   9360

gcatggtgct ttaaccaatt gtacataata ataccactga tagtctacta atgcatttcc   9420

tagatcccag tttttcttga atgattagga atggtgggga gaggggaggg gagatattct   9480

acatgatact tctccaatct tctaaagatt ataagaaaaa ataaaaaatt gaagtcactt   9540

g                                                                   9541


<210>  1749
<211>  794
<212>  PRT
<213>  Homo sapiens

<400>  1749


Met Asn Ile Asp Asp Lys Leu Glu Gly Leu Phe Leu Lys Cys Gly Gly 
1               5                   10                  15      


Ile Asp Glu Met Gln Ser Ser Arg Thr Met Val Val Met Gly Gly Val 
            20                  25                  30          


Ser Gly Gln Ser Thr Val Ser Gly Glu Leu Gln Asp Ser Val Leu Gln 
        35                  40                  45              


Asp Arg Ser Met Pro His Gln Glu Ile Leu Ala Ala Asp Glu Val Leu 
    50                  55                  60                  


Gln Glu Ser Glu Met Arg Gln Gln Asp Met Ile Ser His Asp Glu Leu 
65                  70                  75                  80  


Met Val His Glu Glu Thr Val Lys Asn Asp Glu Glu Gln Met Glu Thr 
                85                  90                  95      


His Glu Arg Leu Pro Gln Gly Leu Gln Tyr Ala Leu Asn Val Pro Ile 
            100                 105                 110         


Ser Val Lys Gln Glu Ile Thr Phe Thr Asp Val Ser Glu Gln Leu Met 
        115                 120                 125             


Arg Asp Lys Lys Gln Ile Arg Glu Pro Val Asp Leu Gln Lys Lys Lys 
    130                 135                 140                 


Lys Arg Lys Gln Arg Ser Pro Ala Lys Ile Leu Thr Ile Asn Glu Asp 
145                 150                 155                 160 


Gly Ser Leu Gly Leu Lys Thr Pro Lys Ser His Val Cys Glu His Cys 
                165                 170                 175     


Asn Ala Ala Phe Arg Thr Asn Tyr His Leu Gln Arg His Val Phe Ile 
            180                 185                 190         


His Thr Gly Glu Lys Pro Phe Gln Cys Ser Gln Cys Asp Met Arg Phe 
        195                 200                 205             


Ile Gln Lys Tyr Leu Leu Gln Arg His Glu Lys Ile His Thr Gly Glu 
    210                 215                 220                 


Lys Pro Phe Arg Cys Asp Glu Cys Gly Met Arg Phe Ile Gln Lys Tyr 
225                 230                 235                 240 


His Met Glu Arg His Lys Arg Thr His Ser Gly Glu Lys Pro Tyr Gln 
                245                 250                 255     


Cys Glu Tyr Cys Leu Gln Tyr Phe Ser Arg Thr Asp Arg Val Leu Lys 
            260                 265                 270         


His Lys Arg Met Cys His Glu Asn His Asp Lys Lys Leu Asn Arg Cys 
        275                 280                 285             


Ala Ile Lys Gly Gly Leu Leu Thr Ser Glu Glu Asp Ser Gly Phe Ser 
    290                 295                 300                 


Thr Ser Pro Lys Asp Asn Ser Leu Pro Lys Lys Lys Arg Gln Lys Thr 
305                 310                 315                 320 


Glu Lys Lys Ser Ser Gly Met Asp Lys Glu Ser Ala Leu Asp Lys Ser 
                325                 330                 335     


Asp Leu Lys Lys Asp Lys Asn Asp Tyr Leu Pro Leu Tyr Ser Ser Ser 
            340                 345                 350         


Thr Lys Val Lys Asp Glu Tyr Met Val Ala Glu Tyr Ala Val Glu Met 
        355                 360                 365             


Pro His Ser Ser Val Gly Gly Ser His Leu Glu Asp Ala Ser Gly Glu 
    370                 375                 380                 


Ile His Pro Pro Lys Leu Val Leu Lys Lys Ile Asn Ser Lys Arg Ser 
385                 390                 395                 400 


Leu Lys Gln Pro Leu Glu Gln Asn Gln Thr Ile Ser Pro Leu Ser Thr 
                405                 410                 415     


Tyr Glu Glu Ser Lys Val Ser Lys Tyr Ala Phe Glu Leu Val Asp Lys 
            420                 425                 430         


Gln Ala Leu Leu Asp Ser Glu Gly Asn Ala Asp Ile Asp Gln Val Asp 
        435                 440                 445             


Asn Leu Gln Glu Gly Pro Ser Lys Pro Val His Ser Ser Thr Asn Tyr 
    450                 455                 460                 


Asp Asp Ala Met Gln Phe Leu Lys Lys Lys Arg Tyr Leu Gln Ala Ala 
465                 470                 475                 480 


Ser Asn Asn Ser Arg Glu Tyr Ala Leu Asn Val Gly Thr Ile Ala Ser 
                485                 490                 495     


Gln Pro Ser Val Thr Gln Ala Ala Val Ala Ser Val Ile Asp Glu Ser 
            500                 505                 510         


Thr Thr Ala Ser Ile Leu Glu Ser Gln Ala Leu Asn Val Glu Ile Lys 
        515                 520                 525             


Ser Asn His Asp Lys Asn Val Ile Pro Asp Glu Val Leu Gln Thr Leu 
    530                 535                 540                 


Leu Asp His Tyr Ser His Lys Ala Asn Gly Gln His Glu Ile Ser Phe 
545                 550                 555                 560 


Ser Val Ala Asp Thr Glu Val Thr Ser Ser Ile Ser Ile Asn Ser Ser 
                565                 570                 575     


Glu Val Pro Glu Val Thr Pro Ser Glu Asn Val Gly Ser Ser Ser Gln 
            580                 585                 590         


Ala Ser Ser Ser Asp Lys Ala Asn Met Leu Gln Glu Tyr Ser Lys Phe 
        595                 600                 605             


Leu Gln Gln Ala Leu Asp Arg Thr Ser Gln Asn Asp Ala Tyr Leu Asn 
    610                 615                 620                 


Ser Pro Ser Leu Asn Phe Val Thr Asp Asn Gln Thr Leu Pro Asn Gln 
625                 630                 635                 640 


Pro Ala Phe Ser Ser Ile Asp Lys Gln Val Tyr Ala Thr Met Pro Ile 
                645                 650                 655     


Asn Ser Phe Arg Ser Gly Met Asn Ser Pro Leu Arg Thr Thr Pro Asp 
            660                 665                 670         


Lys Ser His Phe Gly Leu Ile Val Gly Asp Ser Gln His Ser Phe Pro 
        675                 680                 685             


Phe Ser Gly Asp Glu Thr Asn His Ala Ser Ala Thr Ser Thr Gln Asp 
    690                 695                 700                 


Phe Leu Asp Gln Val Thr Ser Gln Lys Lys Ala Glu Ala Gln Pro Val 
705                 710                 715                 720 


His Gln Ala Tyr Gln Met Ser Ser Phe Glu Gln Pro Phe Arg Ala Pro 
                725                 730                 735     


Tyr His Gly Ser Arg Ala Gly Ile Ala Thr Gln Phe Ser Thr Ala Asn 
            740                 745                 750         


Gly Gln Val Asn Leu Arg Gly Pro Gly Thr Ser Ala Glu Phe Ser Glu 
        755                 760                 765             


Phe Pro Leu Val Asn Val Asn Asp Asn Arg Ala Gly Met Thr Ser Ser 
    770                 775                 780                 


Pro Asp Ala Thr Thr Gly Gln Thr Phe Gly 
785                 790                 

<210>  1750
<211>  1662
<212>  DNA
<213>  Homo sapiens

<400>  1750
ggcgaccgcg gcggcgctct agctgcggca tgtctgcgtc tctactgctc tgggaggagg     60

aagagaagga ggaagaggag gaggaggagg agggggagga agaggagaaa ggcgcagggg    120

tgggagctgt tgccgaagct gccacagcaa aagttctccc ccctcccccc ttcccctcct    180

ctcaaggccc ctagaaaggt tggagctgcc gccgcctgca gtcggtgacc gcgcgactcg    240

gcgcccgccc gcggatagag ggaggaatca gcagcttgga aattcaagca cgtgatctgg    300

cgggatgggc gtttgcctaa cgtatttaat ggaggaatcg gatggcataa gtgattaagg    360

tggtattgag gatttctgaa gcctatgaaa ggtagaaact caaccatgat ttctttttca    420

actctacagc attcctttcc ttgaagtctt cgtttttacc ttagtctcgg gcagttatac    480

ttaagcatga acattgacga caaactggaa ggattgtttc ttaaatgtgg cggcatagac    540

gaaatgcagt cttccaggac aatggttgta atgggtggag tgtctggcca gtctactgtg    600

tctggagagc tacaggattc agtacttcaa gatcgaagta tgcctcacca ggagatcctt    660

gctgcagatg aagtgttaca agaaagtgaa atgagacaac aggatatgat atcacatgat    720

gaactcatgg tccatgagga gacagtgaaa aatgatgaag agcagatgga aacacatgaa    780

agacttcctc aaggactaca gtatgcactt aatgtcccta taagcgtaaa gcaggaaatt    840

acttttactg atgtatctga gcaactgatg agagacaaaa aacaaatcag agagccagta    900

gacttacaga aaaagaagaa gcggaaacaa cgttctcccg caaaaatcct tacaataaat    960

gaggatggat cacttggttt gaaaacccct aaatctcacg tttgtgagca ctgcaatgct   1020

gcctttagaa cgaactatca cttacagaga catgtcttca ttcatacagg tgaaaaacca   1080

tttcaatgta gtcaatgtga catgcgtttc atacagaagt acctgcttca gagacatgag   1140

aagattcata ctggtgaaaa accatttcgc tgtgatgaat gtggtatgag attcatacaa   1200

aaatatcata tggaaaggca taagagaact catagtggag aaaaacctta ccagtgtgaa   1260

tactgtttac agtatttttc cagaacagat cgtgtattga aacataaacg tatgtgccat   1320

gaaaatcatg acaaaaaact aaatagatgt gccatcaaag gtggccttct gacatctgag   1380

gaagattctg gcttttctac atcaccaaaa gacaactcac tgccaaaaaa gaaaaggcag   1440

aaaacggaga aaaaatcatc tggaatggac aaagagagtg ctttggacaa atctgacctg   1500

aaaaaagaca aaaatgatta cttgcctctt tattcttcaa gtactaaagt aaaagatgag   1560

tatatggttg cagaatatgc tgttgaaatg ccacattcgt cagttggggg ctcgcattta   1620

gaagatgcgt caggagaaat acacccacct aagttagttc tc                      1662


<210>  1751
<211>  391
<212>  PRT
<213>  Homo sapiens

<400>  1751


Met Asn Ile Asp Asp Lys Leu Glu Gly Leu Phe Leu Lys Cys Gly Gly 
1               5                   10                  15      


Ile Asp Glu Met Gln Ser Ser Arg Thr Met Val Val Met Gly Gly Val 
            20                  25                  30          


Ser Gly Gln Ser Thr Val Ser Gly Glu Leu Gln Asp Ser Val Leu Gln 
        35                  40                  45              


Asp Arg Ser Met Pro His Gln Glu Ile Leu Ala Ala Asp Glu Val Leu 
    50                  55                  60                  


Gln Glu Ser Glu Met Arg Gln Gln Asp Met Ile Ser His Asp Glu Leu 
65                  70                  75                  80  


Met Val His Glu Glu Thr Val Lys Asn Asp Glu Glu Gln Met Glu Thr 
                85                  90                  95      


His Glu Arg Leu Pro Gln Gly Leu Gln Tyr Ala Leu Asn Val Pro Ile 
            100                 105                 110         


Ser Val Lys Gln Glu Ile Thr Phe Thr Asp Val Ser Glu Gln Leu Met 
        115                 120                 125             


Arg Asp Lys Lys Gln Ile Arg Glu Pro Val Asp Leu Gln Lys Lys Lys 
    130                 135                 140                 


Lys Arg Lys Gln Arg Ser Pro Ala Lys Ile Leu Thr Ile Asn Glu Asp 
145                 150                 155                 160 


Gly Ser Leu Gly Leu Lys Thr Pro Lys Ser His Val Cys Glu His Cys 
                165                 170                 175     


Asn Ala Ala Phe Arg Thr Asn Tyr His Leu Gln Arg His Val Phe Ile 
            180                 185                 190         


His Thr Gly Glu Lys Pro Phe Gln Cys Ser Gln Cys Asp Met Arg Phe 
        195                 200                 205             


Ile Gln Lys Tyr Leu Leu Gln Arg His Glu Lys Ile His Thr Gly Glu 
    210                 215                 220                 


Lys Pro Phe Arg Cys Asp Glu Cys Gly Met Arg Phe Ile Gln Lys Tyr 
225                 230                 235                 240 


His Met Glu Arg His Lys Arg Thr His Ser Gly Glu Lys Pro Tyr Gln 
                245                 250                 255     


Cys Glu Tyr Cys Leu Gln Tyr Phe Ser Arg Thr Asp Arg Val Leu Lys 
            260                 265                 270         


His Lys Arg Met Cys His Glu Asn His Asp Lys Lys Leu Asn Arg Cys 
        275                 280                 285             


Ala Ile Lys Gly Gly Leu Leu Thr Ser Glu Glu Asp Ser Gly Phe Ser 
    290                 295                 300                 


Thr Ser Pro Lys Asp Asn Ser Leu Pro Lys Lys Lys Arg Gln Lys Thr 
305                 310                 315                 320 


Glu Lys Lys Ser Ser Gly Met Asp Lys Glu Ser Ala Leu Asp Lys Ser 
                325                 330                 335     


Asp Leu Lys Lys Asp Lys Asn Asp Tyr Leu Pro Leu Tyr Ser Ser Ser 
            340                 345                 350         


Thr Lys Val Lys Asp Glu Tyr Met Val Ala Glu Tyr Ala Val Glu Met 
        355                 360                 365             


Pro His Ser Ser Val Gly Gly Ser His Leu Glu Asp Ala Ser Gly Glu 
    370                 375                 380                 


Ile His Pro Pro Lys Leu Val 
385                 390     

<210>  1752
<211>  782
<212>  DNA
<213>  Homo sapiens

<400>  1752
gctttcttta acttaattgt ggtcgtgtta atgtagcaca aaaaatatat tttaatgaag     60

attaaatatt ataatttgag gttttgggga ctggtgctga ttccaaaaag ttaatttaat    120

aatatatacc aacagattgt ttgtcacgct tctgaaccaa tgactgaatg tcaagatgtt    180

cgttaatttc tagatgtttg tttcaagacc agctgtttca gatctattaa tgtagggaat    240

ttttccctaa gattgaattc ctatatttac ttggtaagat ccactaatct gttataggga    300

gttgttttct cttgccttat agttgagcta tttggtttga caaagctcag cagaaacttg    360

atgtgaaaaa tctacgattt tcttctacat tcattgatgc cccttgtaat gtttgcatac    420

actagaaaat gccttcaatt tgtatgtagc atttcaatgt gtaagatata tgtactaaac    480

atatgtgttg ctatcttcat cattaacatc cttcttttct attgcttggc tgtaattttt    540

gtaaagataa attatattgt ttttttgtat gtgtgtttgt agtatatgtt cagaaggcaa    600

gcatcttcat tttgctagct ttgcagaatc ttaaaatgtg tactcgttat ttctaatgat    660

gtaaaaaaaa atccctagtc ctgtttagca tttgactttt ttatatgttt taaatgttgc    720

tggatttttg tgctgtttgc caaacttata caataaataa atgaaatatt gtgctgattt    780

tc                                                                   782


<210>  1753
<211>  61
<212>  PRT
<213>  Homo sapiens

<400>  1753


Met Pro Leu Val Met Phe Ala Tyr Thr Arg Lys Cys Leu Gln Phe Val 
1               5                   10                  15      


Cys Ser Ile Ser Met Cys Lys Ile Tyr Val Leu Asn Ile Cys Val Ala 
            20                  25                  30          


Ile Phe Ile Ile Asn Ile Leu Leu Phe Tyr Cys Leu Ala Val Ile Phe 
        35                  40                  45              


Val Lys Ile Asn Tyr Ile Val Phe Leu Tyr Val Cys Leu 
    50                  55                  60      

<210>  1754
<211>  2199
<212>  DNA
<213>  Homo sapiens

<400>  1754
tttttttttt ttttttttaa agagactagg tcttactttg ttgcccaggc tggagggtat     60

tggtacaatc acagctcact gcagcttcaa ccttctgggc tcaagcacac cttccacctc    120

agcctcccaa gtagctagga ctacaggtgc atgccaccac gcctggctaa ttatttttta    180

tttttttgta gaggcagagt gttgctatgt tgcccaggtc gatcttggac tcctggcctt    240

aagcaatcct cctgccttgg cctcccaaag tgctgggatt acaggcatga gccgctgttc    300

ccagattgaa ttaaattttt ttttttcttt ttttagagat ggggtcttgc tgtgtttccc    360

aggctggtct caaacttctg gcctcaaggg attctcccat ctcaacctcc caaagtgctg    420

ggattagcgg cgggagccag cacacctggc caacaactga attaatttta ttttttccaa    480

cttctattat aggttcaggg gttacatgtg caggtttgta aattgcctga catggggatt    540

tggtgtacag atcatttcat cacccagtat gcatcttcta ttgatgatat tttggaagat    600

gaagaacatt atgcagatca gttaaaagag tatctttttt atgcagaagc attgcgggct    660

gtgtgcagga aacatgaact tatgcagtat gacttggaga tggctgctca ggacttagca    720

tccaagaagc agcagtgtga ggaactggta actgggactg tgagaacatt ctctttgaag    780

ggaatgacta ccaagctctt tggtcaagaa actccagagc agagagaagc cagaataaag    840

gtgctagaag aacaaataaa tgaaggagaa caacagctaa agtctaaaaa tctggaaggc    900

agagaatttg tgaaaaacgc atgggctgat attgaacgct tcaaagaaca aaagaaccga    960

gacttaaagg aggccctcat aagctatgca gtcatgcaga tcagtatgtg caaaaaggga   1020

attcaagttt ggaccaatgc taaggaatgc tttagcaaga tgtaatcctg tgaattgaat   1080

ttctcttcaa tcaaagtgcc ccaaaacaga agcacaagta aataaaagaa atttaagtca   1140

ctacctagta tacataaaca tatacaataa gttaaataaa ttcagctttc tttaacttaa   1200

ttgtggtcgt gttaatgtag cacaaaaaat atattttaat gaagattaaa tattataatt   1260

tgaggttttg gggactggtg ctgattccaa aaagttaatt taataatata taccaacaga   1320

ttgtttgtca cgcttctgaa ccaatgactg aatgtcaaga tgttcgttaa tttctagatg   1380

tttgtttcaa gaccagctgt ttcagatcta ttaatgtagg gaatttttcc ctaagattga   1440

attcctatat ttacttggta agatccacta atctgttata gggagttgtt ttctcttgcc   1500

ttatagttga gctatttggt ttgacaaagc tcagcagaaa cttgatgtga aaaatctacg   1560

attttcttct acattcattg atgccccttg taatgtttgc atacactaga aaatgccttc   1620

aatttgtgtt ttaccagaat tttgatactg gtcagaaatt ttatactgcc aacaaagaag   1680

actcaacttc tcagatctat aatgggatac attgtcatcc tctagcaact cctatataga   1740

aagttttaac tgaatatgtt acatataaga attaaattct tctcaaataa ttcttaacct   1800

cagtaatgag cctaaattta ctctgcttgg ctctctacac atggcatttc agggtataag   1860

atgtagcatt tcaatgtgta agatatatgt actaaacata tgtgttgcta tcttcatcat   1920

taacatcctt cttttctatt gcttggctgt aatttttgta aagataaatt atattgtttt   1980

tttgtatgtg tgtttgtagt atatgttcag aaggcaagca tcttcatttt gctagctttg   2040

cagaatctta aaatgtgtac tcgttatttc taatgatgta aaaaaaaatc cctagtcctg   2100

tttagcattt gactttttta tatgttttaa atgttgctgg atttttgtgc tgtttgccaa   2160

acttatacaa taaataaatg aaatattgtg ctgattttc                          2199


<210>  1755
<211>  177
<212>  PRT
<213>  Homo sapiens

<400>  1755


Met Gly Ile Trp Cys Thr Asp His Phe Ile Thr Gln Tyr Ala Ser Ser 
1               5                   10                  15      


Ile Asp Asp Ile Leu Glu Asp Glu Glu His Tyr Ala Asp Gln Leu Lys 
            20                  25                  30          


Glu Tyr Leu Phe Tyr Ala Glu Ala Leu Arg Ala Val Cys Arg Lys His 
        35                  40                  45              


Glu Leu Met Gln Tyr Asp Leu Glu Met Ala Ala Gln Asp Leu Ala Ser 
    50                  55                  60                  


Lys Lys Gln Gln Cys Glu Glu Leu Val Thr Gly Thr Val Arg Thr Phe 
65                  70                  75                  80  


Ser Leu Lys Gly Met Thr Thr Lys Leu Phe Gly Gln Glu Thr Pro Glu 
                85                  90                  95      


Gln Arg Glu Ala Arg Ile Lys Val Leu Glu Glu Gln Ile Asn Glu Gly 
            100                 105                 110         


Glu Gln Gln Leu Lys Ser Lys Asn Leu Glu Gly Arg Glu Phe Val Lys 
        115                 120                 125             


Asn Ala Trp Ala Asp Ile Glu Arg Phe Lys Glu Gln Lys Asn Arg Asp 
    130                 135                 140                 


Leu Lys Glu Ala Leu Ile Ser Tyr Ala Val Met Gln Ile Ser Met Cys 
145                 150                 155                 160 


Lys Lys Gly Ile Gln Val Trp Thr Asn Ala Lys Glu Cys Phe Ser Lys 
                165                 170                 175     


Met 
    

<210>  1756
<211>  2529
<212>  DNA
<213>  Homo sapiens

<400>  1756
ggcggcgcag gcgcactggg ttcgccgcgc cgaactgcag ccatggagca ggcacctccg     60

gaccccgagc ggcagctcca gccggcgccc ttggagccgc tgggctcccc agacgctggg    120

ctgggggctg cggtcggcaa ggaagcggag ggggccggag aagagagctc tggggtcgac    180

acgatgacac acaataattt ttggttgaag aagatagaaa tcagtgtttc agaagcagaa    240

aaacgaactg gaagaaatgc catgaacatg caagaaacat atactgctta cctcattgaa    300

acaaggtcag ttgaacatac cgatggtcag agtgtcctaa cagactcact atggcggcga    360

tatagtgaat ttgagttgtt gagaagctac cttttagttt actatccaca tattgttgtg    420

ccacctctgc cagaaaaacg ggcagaattt gtttggcata aactctctgc tgacaacatg    480

gatccagatt ttgtggagag gcgacggatt ggtttagaaa actttctctt gaggattgct    540

tcacatccca tcctttgtag agacaaaatc ttctatctgt ttttaacaca ggaaggtaac    600

tggaaggaga ctgtgaatga aactgggttt cagctgaagg cagactccag gttaaaagcg    660

cttaatgcaa cattcagagt gaaaaaccca gacaagagat ttactgacct taagcactat    720

agtgatgaac tgcagtctgt catctcacat cttcttcgag tcagagctag agtagcagat    780

cgactctatg gtgtatataa agtacatggg aattatggtc gagttttcag tgaatggagt    840

gccatagaaa aagaaatggg tgatggactg cagagtgctg gtcatcatat ggatgtgtat    900

gcatcttcta ttgatgatat tttggaagat gaagaacatt atgcagatca gttaaaagag    960

tatctttttt atgcagaagc attgcgggct gtgtgcagga aacatgaact tatgcagtat   1020

gacttggaga tggctgctca ggacttagca tccaagaagc agcagtgtga ggaactggta   1080

actgggactg tgagaacatt ctctttgaag ggaatgacta ccaagctctt tggtcaagaa   1140

actccagagc agagagaagc cagaataaag gtgctagaag aacaaataaa tgaaggagaa   1200

caacagctaa agtctaaaaa tctggaaggc agagaatttg tgaaaaacgc atgggctgat   1260

attgaacgct tcaaagaaca aaagaaccga gacttaaagg aggccctcat aagctatgca   1320

gtcatgcaga tcagtatgtg caaaaaggga attcaagttt ggaccaatgc taaggaatgc   1380

tttagcaaga tgtaatcctg tgaattgaat ttctcttcaa tcaaagtgcc ccaaaacaga   1440

agcacaagta aataaaagaa atttaagtca ctacctagta tacataaaca tatacaataa   1500

gttaaataaa ttcagctttc tttaacttaa ttgtggtcgt gttaatgtag cacaaaaaat   1560

atattttaat gaagattaaa tattataatt tgaggttttg gggactggtg ctgattccaa   1620

aaagttaatt taataatata taccaacaga ttgtttgtca cgcttctgaa ccaatgactg   1680

aatgtcaaga tgttcgttaa tttctagatg tttgtttcaa gaccagctgt ttcagatcta   1740

ttaatgtagg gaatttttcc ctaagattga attcctatat ttacttggta agatccacta   1800

atctgttata gggagttgtt ttctcttgcc ttatagttga gctatttggt ttgacaaagc   1860

tcagcagaaa cttgatgtga aaaatctacg attttcttct acattcattg atgccccttg   1920

taatgtttgc atacactaga aaatgccttc aatttgtgtt ttaccagaat tttgatactg   1980

gtcagaaatt ttatactgcc aacaaagaag actcaacttc tcagatctat aatgggatac   2040

attgtcatcc tctagcaact cctatataga aagttttaac tgaatatgtt acatataaga   2100

attaaattct tctcaaataa ttcttaacct cagtaatgag cctaaattta ctctgcttgg   2160

ctctctacac atggcatttc agggtataag atgtagcatt tcaatgtgta agatatatgt   2220

actaaacata tgtgttgcta tcttcatcat taacatcctt cttttctatt gcttggctgt   2280

aatttttgta aagataaatt atattgtttt tttgtatgtg tgtttgtagt atatgttcag   2340

aaggcaagca tcttcatttt gctagctttg cagaatctta aaatgtgtac tcgttatttc   2400

taatgatgta aaaaaaaatc cctagtcctg tttagcattt gactttttta tatgttttaa   2460

atgttgctgg atttttgtgc tgtttgccaa acttatacaa taaataaatg aaatattgtg   2520

ctgattttc                                                           2529


<210>  1757
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  1757


Met Glu Gln Ala Pro Pro Asp Pro Glu Arg Gln Leu Gln Pro Ala Pro 
1               5                   10                  15      


Leu Glu Pro Leu Gly Ser Pro Asp Ala Gly Leu Gly Ala Ala Val Gly 
            20                  25                  30          


Lys Glu Ala Glu Gly Ala Gly Glu Glu Ser Ser Gly Val Asp Thr Met 
        35                  40                  45              


Thr His Asn Asn Phe Trp Leu Lys Lys Ile Glu Ile Ser Val Ser Glu 
    50                  55                  60                  


Ala Glu Lys Arg Thr Gly Arg Asn Ala Met Asn Met Gln Glu Thr Tyr 
65                  70                  75                  80  


Thr Ala Tyr Leu Ile Glu Thr Arg Ser Val Glu His Thr Asp Gly Gln 
                85                  90                  95      


Ser Val Leu Thr Asp Ser Leu Trp Arg Arg Tyr Ser Glu Phe Glu Leu 
            100                 105                 110         


Leu Arg Ser Tyr Leu Leu Val Tyr Tyr Pro His Ile Val Val Pro Pro 
        115                 120                 125             


Leu Pro Glu Lys Arg Ala Glu Phe Val Trp His Lys Leu Ser Ala Asp 
    130                 135                 140                 


Asn Met Asp Pro Asp Phe Val Glu Arg Arg Arg Ile Gly Leu Glu Asn 
145                 150                 155                 160 


Phe Leu Leu Arg Ile Ala Ser His Pro Ile Leu Cys Arg Asp Lys Ile 
                165                 170                 175     


Phe Tyr Leu Phe Leu Thr Gln Glu Gly Asn Trp Lys Glu Thr Val Asn 
            180                 185                 190         


Glu Thr Gly Phe Gln Leu Lys Ala Asp Ser Arg Leu Lys Ala Leu Asn 
        195                 200                 205             


Ala Thr Phe Arg Val Lys Asn Pro Asp Lys Arg Phe Thr Asp Leu Lys 
    210                 215                 220                 


His Tyr Ser Asp Glu Leu Gln Ser Val Ile Ser His Leu Leu Arg Val 
225                 230                 235                 240 


Arg Ala Arg Val Ala Asp Arg Leu Tyr Gly Val Tyr Lys Val His Gly 
                245                 250                 255     


Asn Tyr Gly Arg Val Phe Ser Glu Trp Ser Ala Ile Glu Lys Glu Met 
            260                 265                 270         


Gly Asp Gly Leu Gln Ser Ala Gly His His Met Asp Val Tyr Ala Ser 
        275                 280                 285             


Ser Ile Asp Asp Ile Leu Glu Asp Glu Glu His Tyr Ala Asp Gln Leu 
    290                 295                 300                 


Lys Glu Tyr Leu Phe Tyr Ala Glu Ala Leu Arg Ala Val Cys Arg Lys 
305                 310                 315                 320 


His Glu Leu Met Gln Tyr Asp Leu Glu Met Ala Ala Gln Asp Leu Ala 
                325                 330                 335     


Ser Lys Lys Gln Gln Cys Glu Glu Leu Val Thr Gly Thr Val Arg Thr 
            340                 345                 350         


Phe Ser Leu Lys Gly Met Thr Thr Lys Leu Phe Gly Gln Glu Thr Pro 
        355                 360                 365             


Glu Gln Arg Glu Ala Arg Ile Lys Val Leu Glu Glu Gln Ile Asn Glu 
    370                 375                 380                 


Gly Glu Gln Gln Leu Lys Ser Lys Asn Leu Glu Gly Arg Glu Phe Val 
385                 390                 395                 400 


Lys Asn Ala Trp Ala Asp Ile Glu Arg Phe Lys Glu Gln Lys Asn Arg 
                405                 410                 415     


Asp Leu Lys Glu Ala Leu Ile Ser Tyr Ala Val Met Gln Ile Ser Met 
            420                 425                 430         


Cys Lys Lys Gly Ile Gln Val Trp Thr Asn Ala Lys Glu Cys Phe Ser 
        435                 440                 445             


Lys Met 
    450 

<210>  1758
<211>  1449
<212>  DNA
<213>  Homo sapiens

<400>  1758
ggcggcgcag gcgcactggg ttcgccgcgc cgaactgcag ccatggagca ggcacctccg     60

gaccccgagc ggcagctcca gccggcgccc ttggagccgc tgggctcccc agacgctggg    120

ctgggggctg cggtcggcaa ggaagcggag ggggccggag aagagagctc tggggtcgac    180

acgatgacac acaataattt ttggttgaag aagatagaaa tcagtgtttc agaagcagaa    240

aaacgaactg gaagaaatgc catgaacatg caagaaacat atactgctta cctcattgaa    300

acaaggtcag ttgaacatac cgatggtcag agtgtcctaa cagactcact atggcggcga    360

tatagtgaat ttgagttgtt gagaagctac cttttagttt actatccaca tattgttgtg    420

ccacctctgc cagaaaaacg ggcagaattt gtttggcata aactctctgc tgacaacatg    480

gatccagatt ttgtggagag gcgacggatt ggtttagaaa actttctctt gaggattgct    540

tcacatccca tcctttgtag agacaaaatc ttctatctgt ttttaacaca ggaaggtaac    600

tggaaggaga ctgtgaatga aactgggttt cagctgaagg cagactccag gttaaaagcg    660

cttaatgcaa cattcagagt gaaaaaccca gacaagagat ttactgacct taagcactat    720

agtgatgaac tgcagtctgt catctcacat cttcttcgag tcagagctag agtagcagat    780

cgactctatg gtgtatataa agtacatggg aattatggtc gagttttcag tgaatggagt    840

gccatagaaa aagaaatggg tgatggactg cagagtgctg gtcatcatat ggatgtgtat    900

gcatcttcta ttgatgatat tttggaagat gaagaacatt atgcagatca gttaaaagag    960

tatctttttt atgcagaagc attgcgggct gtgtgcagga aacatgaact tatgcagtat   1020

gacttggaga tggctgctca ggacttagca tccaagaagc agcagtgtga ggaactggta   1080

actgggactg tgagaacatt ctctttgaag ggaatgacta ccaagctctt tggtcaagaa   1140

actccagagc agagagaagc cagaataaag gtgctagaag aacaaataaa tgaaggagaa   1200

caacagctaa agtctaaaaa tctggaaggc agagaatttg tgaaaaacgc atgggctgat   1260

attgaacgct tcaaagaaca aaagaaccga gacttaaagg aggccctcat aagctatgca   1320

gtcatgcaga tcagtatgtg caaaaaggga attcaagttt ggaccaatgc taaggaatgc   1380

tttagcaaga tgtaatcctg tgaattgaat ttctcttcaa tcaaagtgcc ccaaaacaga   1440

agcacaagt                                                           1449


<210>  1759
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  1759


Met Glu Gln Ala Pro Pro Asp Pro Glu Arg Gln Leu Gln Pro Ala Pro 
1               5                   10                  15      


Leu Glu Pro Leu Gly Ser Pro Asp Ala Gly Leu Gly Ala Ala Val Gly 
            20                  25                  30          


Lys Glu Ala Glu Gly Ala Gly Glu Glu Ser Ser Gly Val Asp Thr Met 
        35                  40                  45              


Thr His Asn Asn Phe Trp Leu Lys Lys Ile Glu Ile Ser Val Ser Glu 
    50                  55                  60                  


Ala Glu Lys Arg Thr Gly Arg Asn Ala Met Asn Met Gln Glu Thr Tyr 
65                  70                  75                  80  


Thr Ala Tyr Leu Ile Glu Thr Arg Ser Val Glu His Thr Asp Gly Gln 
                85                  90                  95      


Ser Val Leu Thr Asp Ser Leu Trp Arg Arg Tyr Ser Glu Phe Glu Leu 
            100                 105                 110         


Leu Arg Ser Tyr Leu Leu Val Tyr Tyr Pro His Ile Val Val Pro Pro 
        115                 120                 125             


Leu Pro Glu Lys Arg Ala Glu Phe Val Trp His Lys Leu Ser Ala Asp 
    130                 135                 140                 


Asn Met Asp Pro Asp Phe Val Glu Arg Arg Arg Ile Gly Leu Glu Asn 
145                 150                 155                 160 


Phe Leu Leu Arg Ile Ala Ser His Pro Ile Leu Cys Arg Asp Lys Ile 
                165                 170                 175     


Phe Tyr Leu Phe Leu Thr Gln Glu Gly Asn Trp Lys Glu Thr Val Asn 
            180                 185                 190         


Glu Thr Gly Phe Gln Leu Lys Ala Asp Ser Arg Leu Lys Ala Leu Asn 
        195                 200                 205             


Ala Thr Phe Arg Val Lys Asn Pro Asp Lys Arg Phe Thr Asp Leu Lys 
    210                 215                 220                 


His Tyr Ser Asp Glu Leu Gln Ser Val Ile Ser His Leu Leu Arg Val 
225                 230                 235                 240 


Arg Ala Arg Val Ala Asp Arg Leu Tyr Gly Val Tyr Lys Val His Gly 
                245                 250                 255     


Asn Tyr Gly Arg Val Phe Ser Glu Trp Ser Ala Ile Glu Lys Glu Met 
            260                 265                 270         


Gly Asp Gly Leu Gln Ser Ala Gly His His Met Asp Val Tyr Ala Ser 
        275                 280                 285             


Ser Ile Asp Asp Ile Leu Glu Asp Glu Glu His Tyr Ala Asp Gln Leu 
    290                 295                 300                 


Lys Glu Tyr Leu Phe Tyr Ala Glu Ala Leu Arg Ala Val Cys Arg Lys 
305                 310                 315                 320 


His Glu Leu Met Gln Tyr Asp Leu Glu Met Ala Ala Gln Asp Leu Ala 
                325                 330                 335     


Ser Lys Lys Gln Gln Cys Glu Glu Leu Val Thr Gly Thr Val Arg Thr 
            340                 345                 350         


Phe Ser Leu Lys Gly Met Thr Thr Lys Leu Phe Gly Gln Glu Thr Pro 
        355                 360                 365             


Glu Gln Arg Glu Ala Arg Ile Lys Val Leu Glu Glu Gln Ile Asn Glu 
    370                 375                 380                 


Gly Glu Gln Gln Leu Lys Ser Lys Asn Leu Glu Gly Arg Glu Phe Val 
385                 390                 395                 400 


Lys Asn Ala Trp Ala Asp Ile Glu Arg Phe Lys Glu Gln Lys Asn Arg 
                405                 410                 415     


Asp Leu Lys Glu Ala Leu Ile Ser Tyr Ala Val Met Gln Ile Ser Met 
            420                 425                 430         


Cys Lys Lys Gly Ile Gln Val Trp Thr Asn Ala Lys Glu Cys Phe Ser 
        435                 440                 445             


Lys Met 
    450 

<210>  1760
<211>  1552
<212>  DNA
<213>  Homo sapiens

<400>  1760
cctcttcctg ggcggcgatc tctgggacag atgcgcagaa gacttcctgc tcaacgacga     60

cgtcctccct gagagcgccc aggaaaacgt ccacttccag cccagcagac gagtcgtcct    120

gcgctcctga gcgttcgtcg acagagctca ggaggacctc tgggatcagg atgagggtgt    180

gtccatcgag agacactcgc aggatcgacg ttggcgggag ctccagcacc aggtcgacgt    240

cgtccagggg cacacgcagg gcacagcccg cggccaggac cactatggag cactttgagt    300

atatcatccc actgtctcct ggagggcaag attcagcctt aagggggttc ccttgtatgt    360

gagtgctgca agaactgggt gtgactcgga atccctccca accacttccg gcgcaagtgg    420

cttctgataa tcatggcgcc cctcggaaca actgtattgc tgtggagcct cttgaggagt    480

tctccgggcg tggaacgggt ctgtttccgg gctcgaatcc agccctggca cggtggcctg    540

ctccaaccgc taccttgctc tttcgagatg gggctgccac gccgccggtt cagctccgag    600

gccgcagaat ctggtagccc agagaccaag aaacctacat ttatggatga ggaagttcaa    660

agcatactca cgaaaatgac aggcttgaac ttgcagaaga cttttaagcc agctatacaa    720

gaactgaagc caccaaccta taagctaatg actcaggcac agttggaaga ggctacaaga    780

caggcagttg aggcagctaa agtacgatta aaaatgccac cagttctgga agagcgagta    840

ccaataaatg atgtgttagc tgaagataag attttggaag gaacagaaac aaccaaatat    900

gtgtttactg atatatcata tagcatacca caccgggagc gttttattgt cgtcagagaa    960

ccaagtggca cactacgcaa agcctcttgg gaagaacggg accgaatgat acaagtttat   1020

ttcccaaaag aaggtcgtaa aattttgaca ccaataattt tcaaggaaga aaatcttagg   1080

actatgtata gccaggacag gcatgttgat gtcctcaatc tctgctttgc ccagtttgag   1140

ccagattcca cagagtatat caaggttcat cacaagacct atgaagatat agataaacgt   1200

ggaaaatatg accttttacg ttcaacaaga tactttggtg gaatggtgtg gtattttgta   1260

aataataaaa agattgatgg tttgctgatt gaccagattc agagagattt aatcgatgat   1320

gcaaccaact tggtccagct gtatcacgtg ctccatccag atggccagtc ggctcaaggg   1380

gccaaggatc aggctgctga gggaataaat ttaatcaagg tctttgcaaa aacagaagca   1440

cagaagggag cctatataga actaacactg cagacttatc aagaagcact cagtcgccat   1500

tctgcagctt cctaaaaata ttttaaaaat acatttattt tactaaatac tg           1552


<210>  1761
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  1761


Met Ala Pro Leu Gly Thr Thr Val Leu Leu Trp Ser Leu Leu Arg Ser 
1               5                   10                  15      


Ser Pro Gly Val Glu Arg Val Cys Phe Arg Ala Arg Ile Gln Pro Trp 
            20                  25                  30          


His Gly Gly Leu Leu Gln Pro Leu Pro Cys Ser Phe Glu Met Gly Leu 
        35                  40                  45              


Pro Arg Arg Arg Phe Ser Ser Glu Ala Ala Glu Ser Gly Ser Pro Glu 
    50                  55                  60                  


Thr Lys Lys Pro Thr Phe Met Asp Glu Glu Val Gln Ser Ile Leu Thr 
65                  70                  75                  80  


Lys Met Thr Gly Leu Asn Leu Gln Lys Thr Phe Lys Pro Ala Ile Gln 
                85                  90                  95      


Glu Leu Lys Pro Pro Thr Tyr Lys Leu Met Thr Gln Ala Gln Leu Glu 
            100                 105                 110         


Glu Ala Thr Arg Gln Ala Val Glu Ala Ala Lys Val Arg Leu Lys Met 
        115                 120                 125             


Pro Pro Val Leu Glu Glu Arg Val Pro Ile Asn Asp Val Leu Ala Glu 
    130                 135                 140                 


Asp Lys Ile Leu Glu Gly Thr Glu Thr Thr Lys Tyr Val Phe Thr Asp 
145                 150                 155                 160 


Ile Ser Tyr Ser Ile Pro His Arg Glu Arg Phe Ile Val Val Arg Glu 
                165                 170                 175     


Pro Ser Gly Thr Leu Arg Lys Ala Ser Trp Glu Glu Arg Asp Arg Met 
            180                 185                 190         


Ile Gln Val Tyr Phe Pro Lys Glu Gly Arg Lys Ile Leu Thr Pro Ile 
        195                 200                 205             


Ile Phe Lys Glu Glu Asn Leu Arg Thr Met Tyr Ser Gln Asp Arg His 
    210                 215                 220                 


Val Asp Val Leu Asn Leu Cys Phe Ala Gln Phe Glu Pro Asp Ser Thr 
225                 230                 235                 240 


Glu Tyr Ile Lys Val His His Lys Thr Tyr Glu Asp Ile Asp Lys Arg 
                245                 250                 255     


Gly Lys Tyr Asp Leu Leu Arg Ser Thr Arg Tyr Phe Gly Gly Met Val 
            260                 265                 270         


Trp Tyr Phe Val Asn Asn Lys Lys Ile Asp Gly Leu Leu Ile Asp Gln 
        275                 280                 285             


Ile Gln Arg Asp Leu Ile Asp Asp Ala Thr Asn Leu Val Gln Leu Tyr 
    290                 295                 300                 


His Val Leu His Pro Asp Gly Gln Ser Ala Gln Gly Ala Lys Asp Gln 
305                 310                 315                 320 


Ala Ala Glu Gly Ile Asn Leu Ile Lys Val Phe Ala Lys Thr Glu Ala 
                325                 330                 335     


Gln Lys Gly Ala Tyr Ile Glu Leu Thr Leu Gln Thr Tyr Gln Glu Ala 
            340                 345                 350         


Leu Ser Arg His Ser Ala Ala Ser 
        355                 360 

<210>  1762
<211>  1636
<212>  DNA
<213>  Homo sapiens

<400>  1762
cctcttcctg ggcggcgatc tctgggacag atgcgcagaa gacttcctgc tcaacgacga     60

cgtcctccct gagagcgccc aggaaaacgt ccacttccag cccagcagac gagtcgtcct    120

gcgctcctga gcgttcgtcg acagagctca ggaggacctc tgggatcagg atgagggtgt    180

gtccatcgag agacactcgc aggatcgacg ttggcgggag ctccagcacc aggtcgacgt    240

cgtccagggg cacacgcagg gcacagcccg cggccaggac cactatggag cactttgagt    300

atatcatccc actgtctcct ggagggcaag attcagcctt aagggggttc ccttgtatgt    360

gagtgctgca agaactgggt gtgactcgga atccctccca accacttccg gcgcaagtgg    420

cttctgataa tcatggcgcc cctcggaaca actgtattgc tgtggagcct cttgaggagt    480

tctccgggcg tggaacgggt ctgtttccgg gctcgaatcc agccctggca cggtggcctg    540

ctccaaccgc taccttgctc tttcgagatg gggctgccac gccgccggtt cagctccgag    600

gccgcagaat ctggtagccc agagaccaag aaacctacat ttatggatga ggaagttcaa    660

agcatactca cgaaaatgac aggcttgaac ttgcagaaga cttttaagcc agctatacaa    720

gaactgaagc caccaaccta taagctaatg actcaggcac agttggaaga ggctacaaga    780

caggcagttg aggcagctaa agtacgatta aaaatgccac cagttctgga agagcgagta    840

ccaataaatg atgtgttagc tgaagataag attttggaag gaacagaaac aaccaaatat    900

gtgtttactg atatatcata tagcatacca caccgggagc gttttattgt cgtcagagaa    960

ccaagtggca cactacgcaa agcctcttgg gaagaacggg accgaatgat acaagtttat   1020

ttcccaaaag aaggtcgtaa aattttgaca ccaataattt tcaaggaaga aaatcttagg   1080

actatgtata gccaggacag gcatgttgat gtcctcaatc tctgctttgc ccagtttgag   1140

ccagattcca cagagtatat caaggttcat cacaagacct atgaagatat agataaacgt   1200

ggaaaatatg accttttacg ttcaacaaga tactttggtg gaatggtgtg gtattttgta   1260

aataataaaa agattgatgg tttgctgatt gaccagattc agagagattt aatcgatgat   1320

gcaaccaact tggtccagct gtatcacgtg ctccatccag atggccagtc ggctcaaggg   1380

gccaaggatc aggctgctga gggaataaat ttaatcaagg tctttgcaaa aacagaagca   1440

cagaagggag cctatataga actaacactg cagacttatc aagaagcact cagtcgccat   1500

tctgcagctt cctaaaaata ttttaaaaat acatttattt tactaaatac tgactacatt   1560

tctctgttaa tattgagcta aatgttaaaa aatggccaga ttaaaagata tcaatttgta   1620

gttctcccta caaagc                                                   1636


<210>  1763
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  1763


Met Ala Pro Leu Gly Thr Thr Val Leu Leu Trp Ser Leu Leu Arg Ser 
1               5                   10                  15      


Ser Pro Gly Val Glu Arg Val Cys Phe Arg Ala Arg Ile Gln Pro Trp 
            20                  25                  30          


His Gly Gly Leu Leu Gln Pro Leu Pro Cys Ser Phe Glu Met Gly Leu 
        35                  40                  45              


Pro Arg Arg Arg Phe Ser Ser Glu Ala Ala Glu Ser Gly Ser Pro Glu 
    50                  55                  60                  


Thr Lys Lys Pro Thr Phe Met Asp Glu Glu Val Gln Ser Ile Leu Thr 
65                  70                  75                  80  


Lys Met Thr Gly Leu Asn Leu Gln Lys Thr Phe Lys Pro Ala Ile Gln 
                85                  90                  95      


Glu Leu Lys Pro Pro Thr Tyr Lys Leu Met Thr Gln Ala Gln Leu Glu 
            100                 105                 110         


Glu Ala Thr Arg Gln Ala Val Glu Ala Ala Lys Val Arg Leu Lys Met 
        115                 120                 125             


Pro Pro Val Leu Glu Glu Arg Val Pro Ile Asn Asp Val Leu Ala Glu 
    130                 135                 140                 


Asp Lys Ile Leu Glu Gly Thr Glu Thr Thr Lys Tyr Val Phe Thr Asp 
145                 150                 155                 160 


Ile Ser Tyr Ser Ile Pro His Arg Glu Arg Phe Ile Val Val Arg Glu 
                165                 170                 175     


Pro Ser Gly Thr Leu Arg Lys Ala Ser Trp Glu Glu Arg Asp Arg Met 
            180                 185                 190         


Ile Gln Val Tyr Phe Pro Lys Glu Gly Arg Lys Ile Leu Thr Pro Ile 
        195                 200                 205             


Ile Phe Lys Glu Glu Asn Leu Arg Thr Met Tyr Ser Gln Asp Arg His 
    210                 215                 220                 


Val Asp Val Leu Asn Leu Cys Phe Ala Gln Phe Glu Pro Asp Ser Thr 
225                 230                 235                 240 


Glu Tyr Ile Lys Val His His Lys Thr Tyr Glu Asp Ile Asp Lys Arg 
                245                 250                 255     


Gly Lys Tyr Asp Leu Leu Arg Ser Thr Arg Tyr Phe Gly Gly Met Val 
            260                 265                 270         


Trp Tyr Phe Val Asn Asn Lys Lys Ile Asp Gly Leu Leu Ile Asp Gln 
        275                 280                 285             


Ile Gln Arg Asp Leu Ile Asp Asp Ala Thr Asn Leu Val Gln Leu Tyr 
    290                 295                 300                 


His Val Leu His Pro Asp Gly Gln Ser Ala Gln Gly Ala Lys Asp Gln 
305                 310                 315                 320 


Ala Ala Glu Gly Ile Asn Leu Ile Lys Val Phe Ala Lys Thr Glu Ala 
                325                 330                 335     


Gln Lys Gly Ala Tyr Ile Glu Leu Thr Leu Gln Thr Tyr Gln Glu Ala 
            340                 345                 350         


Leu Ser Arg His Ser Ala Ala Ser 
        355                 360 

<210>  1764
<211>  2461
<212>  DNA
<213>  Homo sapiens

<400>  1764
cctcttcctg ggcggcgatc tctgggacag atgcgcagaa gacttcctgc tcaacgacga     60

cgtcctccct gagagcgccc aggaaaacgt ccacttccag cccagcagac gagtcgtcct    120

gcgctcctga gcgttcgtcg acagagctca ggaggacctc tgggatcagg atgagggtgt    180

gtccatcgag agacactcgc aggatcgacg ttggcgggag ctccagcacc aggtcgacgt    240

cgtccagggg cacacgcagg gcacagcccg cggccaggac cactatggag cactttgagt    300

atatcatccc actgtctcct ggagggcaag attcagcctt aagggggttc ccttgtatgt    360

gagtgctgca agaactgggt gtgactcgga atccctccca accacttccg gcgcaagtgg    420

cttctgataa tcatggcgcc cctcggaaca actgtattgc tgtggagcct cttgaggagt    480

tctccgggcg tggaacgggt ctgtttccgg gctcgaatcc agccctggca cggtggcctg    540

ctccaaccgc taccttgctc tttcgagatg gggctgccac gccgccggtt cagctccgag    600

gccgcagaat ctggtagccc agagaccaag aaacctacat ttatggatga ggaagttcaa    660

agcatactca cgaaaatgac aggcttgaac ttgcagaaga cttttaagcc agctatacaa    720

gaactgaagc caccaaccta taagctaatg actcaggcac agttggaaga ggctacaaga    780

caggcagttg aggcagctaa agtacgatta aaaatgccac cagttctgga agagcgagta    840

ccaataaatg atgtgttagc tgaagataag attttggaag gaacagaaac aaccaaatat    900

gtgtttactg atatatcata tagcatacca caccgggagc gttttattgt cgtcagagaa    960

ccaagtggca cactacgcaa agcctcttgg gaagaacggg accgaatgat acaagtttat   1020

ttcccaaaag aaggtcgtaa aattttgaca ccaataattt tcaaggaaga aaatcttagg   1080

actatgtata gccaggacag gcatgttgat gtcctcaatc tctgctttgc ccagtttgag   1140

ccagattcca cagagtatat caaggttcat cacaagacct atgaagatat agataaacgt   1200

ggaaaatatg accttttacg ttcaacaaga tactttggtg gaatggtgtg gtattttgta   1260

aataataaaa agattgatgg tttgctgatt gaccagattc agagagattt aatcgatgat   1320

gcaaccaact tggtccagct gtatcacgtg ctccatccag atggccagtc ggctcaaggg   1380

gccaaggatc aggctgctga gggaataaat ttaatcaagg tctttgcaaa aacagaagca   1440

cagaagggag cctatataga actaacactg cagacttatc aagaagcact cagtcgccat   1500

tctgcagctt cctaaaaata ttttaaaaat acatttattt tactaaatac tgactacatt   1560

tctctgttaa tattgagcta aatgttaaaa aatggccaga ttaaaagata tcaatttgta   1620

gttctcccta caaagcaaaa attattaccc tactcacttt tcgtaggcta caaggatatt   1680

tgagtgcctg gttatgaatt tctcaaatca tgttagatga gcgtacggtt aaaaagtctg   1740

gtgtgttttt gtgttaccaa atagggcaaa cgttaactta gacagacccc cagcttaatg   1800

aggtcagagg aacagaggtt tcacatcctg actccagaaa tgggtagctg ctagacaaaa   1860

tcggggcaag acctgtggaa tgatgcaatg aggtcaagaa aaagggttta gagaattaca   1920

gcctggatat tcagctctaa gaaaaatgtg attgacaaca tttgaaaatg cagatttagt   1980

tatacaaaga aaagacagtg gggctgatcc ctaggcaagg tgtagtttcg gctcagcctt   2040

ctaaaactag aagcctattt tcattattga gaaaggaaac aagtaccttc attaattcaa   2100

aaggttttat gagatatggt ctaatagtat gaaaaaaatc aaagcccatg tctgttttag   2160

ttaacaagga aaacacagtg atttaaatgc tgcacataaa ctcttcttaa gatgatgtgg   2220

gcattgtgct cccagtggtc cacagcattt acatataaaa atctaagaag tttctcatag   2280

tccaaagcac tgtggtcagg gtagcaatca atacctatat ataataatga tctgtttagt   2340

caggtaaatg gaaagcatta cagtcaatca tccaaaatat cttcatccag attgatatct   2400

gttgtgtcaa tatcttctaa ttccaaatta tccaaatcta cttctagttc gagtaaactc   2460

t                                                                   2461


<210>  1765
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  1765


Met Ala Pro Leu Gly Thr Thr Val Leu Leu Trp Ser Leu Leu Arg Ser 
1               5                   10                  15      


Ser Pro Gly Val Glu Arg Val Cys Phe Arg Ala Arg Ile Gln Pro Trp 
            20                  25                  30          


His Gly Gly Leu Leu Gln Pro Leu Pro Cys Ser Phe Glu Met Gly Leu 
        35                  40                  45              


Pro Arg Arg Arg Phe Ser Ser Glu Ala Ala Glu Ser Gly Ser Pro Glu 
    50                  55                  60                  


Thr Lys Lys Pro Thr Phe Met Asp Glu Glu Val Gln Ser Ile Leu Thr 
65                  70                  75                  80  


Lys Met Thr Gly Leu Asn Leu Gln Lys Thr Phe Lys Pro Ala Ile Gln 
                85                  90                  95      


Glu Leu Lys Pro Pro Thr Tyr Lys Leu Met Thr Gln Ala Gln Leu Glu 
            100                 105                 110         


Glu Ala Thr Arg Gln Ala Val Glu Ala Ala Lys Val Arg Leu Lys Met 
        115                 120                 125             


Pro Pro Val Leu Glu Glu Arg Val Pro Ile Asn Asp Val Leu Ala Glu 
    130                 135                 140                 


Asp Lys Ile Leu Glu Gly Thr Glu Thr Thr Lys Tyr Val Phe Thr Asp 
145                 150                 155                 160 


Ile Ser Tyr Ser Ile Pro His Arg Glu Arg Phe Ile Val Val Arg Glu 
                165                 170                 175     


Pro Ser Gly Thr Leu Arg Lys Ala Ser Trp Glu Glu Arg Asp Arg Met 
            180                 185                 190         


Ile Gln Val Tyr Phe Pro Lys Glu Gly Arg Lys Ile Leu Thr Pro Ile 
        195                 200                 205             


Ile Phe Lys Glu Glu Asn Leu Arg Thr Met Tyr Ser Gln Asp Arg His 
    210                 215                 220                 


Val Asp Val Leu Asn Leu Cys Phe Ala Gln Phe Glu Pro Asp Ser Thr 
225                 230                 235                 240 


Glu Tyr Ile Lys Val His His Lys Thr Tyr Glu Asp Ile Asp Lys Arg 
                245                 250                 255     


Gly Lys Tyr Asp Leu Leu Arg Ser Thr Arg Tyr Phe Gly Gly Met Val 
            260                 265                 270         


Trp Tyr Phe Val Asn Asn Lys Lys Ile Asp Gly Leu Leu Ile Asp Gln 
        275                 280                 285             


Ile Gln Arg Asp Leu Ile Asp Asp Ala Thr Asn Leu Val Gln Leu Tyr 
    290                 295                 300                 


His Val Leu His Pro Asp Gly Gln Ser Ala Gln Gly Ala Lys Asp Gln 
305                 310                 315                 320 


Ala Ala Glu Gly Ile Asn Leu Ile Lys Val Phe Ala Lys Thr Glu Ala 
                325                 330                 335     


Gln Lys Gly Ala Tyr Ile Glu Leu Thr Leu Gln Thr Tyr Gln Glu Ala 
            340                 345                 350         


Leu Ser Arg His Ser Ala Ala Ser 
        355                 360 

<210>  1766
<211>  651
<212>  DNA
<213>  Homo sapiens

<400>  1766
gctgtctccg cttattacac ctccccgccc cctgccatgg ccggcactga ctctgcctct     60

gacgctgagg atacgcactg cacacgccct gccagatgcc aaaggaagcc attcttctgg    120

aagaagactt tctcctgaaa gcctcctgga ggcaaagttc tggcagaacg aggcaatttc    180

cctccctgca ggcggaagga aggcaattag agcgggagct agggctgaga gaggggaaat    240

gatgcagaca ctgccaccca gcaagtgaga ggaaggactg aacatggaca gaagggcttg    300

agacattgag ccttggctgc tttcacccat cccttcaatt gctgccctct tttctaatgg    360

cctgagtctc caaatggagc caagctgggg gcaccctggc caggagatgt ggcctgctgt    420

gcccctgaga agagctgtcc caggcacaca gagacaacat ttggaagtgg aaaatgcctc    480

tggagcagtc agagtgttgg gaagtctcat cccattctcc gtttcaggaa ccttccctca    540

gcaacagcag agcagaaggg aactcagttc agcataactc ggcaatgctg caagaactgg    600

gtgtgactcg gaatccctcc caaccacttc cggcgcaagt ggcttctgat a             651


<210>  1767
<211>  58
<212>  PRT
<213>  Homo sapiens

<400>  1767


Met Pro Leu Glu Gln Ser Glu Cys Trp Glu Val Ser Ser His Ser Pro 
1               5                   10                  15      


Phe Gln Glu Pro Ser Leu Ser Asn Ser Arg Ala Glu Gly Asn Ser Val 
            20                  25                  30          


Gln His Asn Ser Ala Met Leu Gln Glu Leu Gly Val Thr Arg Asn Pro 
        35                  40                  45              


Ser Gln Pro Leu Pro Ala Gln Val Ala Ser 
    50                  55              

<210>  1768
<211>  788
<212>  DNA
<213>  Homo sapiens

<400>  1768
aaccacttcc ggcgcaagtg gcttctgata atcatggcgc ccctcggaac aactgtattg     60

ctgtggagcc tcttgaggag ttctccgggc gtggaacggg tctgtttccg ggctcgaatc    120

cagccctggc acggtggcct gctccaaccg ctaccttgct ctttcgagat ggggctgcca    180

cgccgccggt tcagctccga ggccgcagaa tctggtagcc cagagaccaa gaaacctaca    240

tttatggatg aggaagttca aagcatactc acgaaaatga caggcttgaa cttgcagaag    300

acttttaagc cagctataca agaactgaag ccaccaacct ataagctaat gactcaggca    360

cagttggaag aggctacaag acaggcagtt gaggcagcta aagtacgatt aaaaatgcca    420

ccagttctgg aagagcgagt accaataaat gatgtgttag ctgaagataa gattttggaa    480

ggaacagaaa caaccaaata tgtgtttact gatatatcat atagcatacc acaccggtgt    540

tgatggaagt ttcatctatg ttatcttcag aacacattta gagactccta cacctctgaa    600

aacttgagag tcagtactgt ttggttaatt tatacattaa tcaggagcgt tttattgtcg    660

tcagagaacc aagtggcaca ctacgcaaag cctcttggga agaacgggac cgaatgatac    720

aagtttattt cccaaaagaa ggtcgtaaaa ttttgacacc aataattttc aaggaagaaa    780

atcttagg                                                             788


<210>  1769
<211>  169
<212>  PRT
<213>  Homo sapiens

<400>  1769


Met Ala Pro Leu Gly Thr Thr Val Leu Leu Trp Ser Leu Leu Arg Ser 
1               5                   10                  15      


Ser Pro Gly Val Glu Arg Val Cys Phe Arg Ala Arg Ile Gln Pro Trp 
            20                  25                  30          


His Gly Gly Leu Leu Gln Pro Leu Pro Cys Ser Phe Glu Met Gly Leu 
        35                  40                  45              


Pro Arg Arg Arg Phe Ser Ser Glu Ala Ala Glu Ser Gly Ser Pro Glu 
    50                  55                  60                  


Thr Lys Lys Pro Thr Phe Met Asp Glu Glu Val Gln Ser Ile Leu Thr 
65                  70                  75                  80  


Lys Met Thr Gly Leu Asn Leu Gln Lys Thr Phe Lys Pro Ala Ile Gln 
                85                  90                  95      


Glu Leu Lys Pro Pro Thr Tyr Lys Leu Met Thr Gln Ala Gln Leu Glu 
            100                 105                 110         


Glu Ala Thr Arg Gln Ala Val Glu Ala Ala Lys Val Arg Leu Lys Met 
        115                 120                 125             


Pro Pro Val Leu Glu Glu Arg Val Pro Ile Asn Asp Val Leu Ala Glu 
    130                 135                 140                 


Asp Lys Ile Leu Glu Gly Thr Glu Thr Thr Lys Tyr Val Phe Thr Asp 
145                 150                 155                 160 


Ile Ser Tyr Ser Ile Pro His Arg Cys 
                165                 

<210>  1770
<211>  1807
<212>  DNA
<213>  Homo sapiens

<400>  1770
aaccacttcc ggcgcaagtg gcttctgata atcatggcgc ccctcggaac aactgtattg     60

ctgtggagcc tcttgaggag ttctccgggc gtggaacggg tctgtttccg ggctcgaatc    120

cagccctggc acggtggcct gctccaaccg ctaccttgct ctttcgagat ggggctgcca    180

cgccgccggt tcagctccga ggccgcagaa tctggtagcc cagagaccaa gaaacctaca    240

tttatggatg aggaagttca aagcatactc acgaaaatga caggcttgaa cttgcagaag    300

acttttaagc cagctataca agaactgaag ccaccaacct ataagctaat gactcaggca    360

cagttggaag aggctacaag acaggcagtt gaggcagcta aagtacgatt aaaaatgcca    420

ccagttctgg aagagcgagt accaataaat gatgtgttag ctgaagataa gattttggaa    480

ggaacagaaa caaccaaata tgtgtttact gatatatcat atagcatacc acaccgggag    540

cgttttattg tcgtcagaga accaagtggc acactacgca aagcctcttg ggaagaacgg    600

gaccgaatga tacaagttta tttcccaaaa gaaggtcgta aaattttgac accaataatt    660

ttcaaggaag aaaatcttag ggtaaggtga cttaggtttt atgttttaga gccagtggtg    720

atgatttatt tgtagaacca gttggctttg tgccttgatc cagataaaca tttctaatga    780

taacttgact tttttttttt tttgaaatgg agtttcgctc cttttgccca ggctgaagtg    840

cagtggcggg atctcagctc actgcaacct ccaccttctg gtttcaagtg attcttctgc    900

ctcagcctca tgagtagctg ggattacagg cgcccgccac cacgcttggc taatttttgt    960

atttttagta gagatggggt ttcaccatgt tggccaggct ggtcttgaac tcctgacctc   1020

gggattcgca cccccccccc gcaatccgac tcccaaagtg ctgggattac aggcgtgagc   1080

caccatgcct ggccgacttc tttcttaata gaatcctcct taccacccaa gatgggttgt   1140

actagggttc tctcataatt ggcttagctg gaatttgaat ctaggtgtga caattacaaa   1200

gcctgtgttc tttctttatg cttcttgagg agcacagagt ggccagtatg tgggtgggca   1260

ggcctgtcat gacatcagga caggtgctga acttcagtgt tctcatgtga tgctaactct   1320

gctgtgtggt tttagactat gtatagccag gacaggcatg ttgatgtcct caatctctgc   1380

tttgcccagt ttgagccaga ttccacagag tatatcaagg ttcatcacaa gacctatgaa   1440

gatatagata aacgtggaaa atatgacctt ttacgttcaa caagatactt tggtggaatg   1500

gtgtggtatt ttgtaaataa taaaaagatt gatggtttgc tgattgacca gattcagaga   1560

gatttaatcg atgatgcaac caacttggtc cagctgtatc acgtgctcca tccagatggc   1620

cagtcggctc aaggggccaa ggatcaggct gctgagggaa taaatttaat caaggtcttt   1680

gcaaaaacag aagcacagaa gggagcctat atagaactaa cactgcagac ttatcaagaa   1740

gcactcagtc gccattctgc agcttcctaa aaatatttta aaaatacatt tattttacta   1800

aatactg                                                             1807


<210>  1771
<211>  218
<212>  PRT
<213>  Homo sapiens

<400>  1771


Met Ala Pro Leu Gly Thr Thr Val Leu Leu Trp Ser Leu Leu Arg Ser 
1               5                   10                  15      


Ser Pro Gly Val Glu Arg Val Cys Phe Arg Ala Arg Ile Gln Pro Trp 
            20                  25                  30          


His Gly Gly Leu Leu Gln Pro Leu Pro Cys Ser Phe Glu Met Gly Leu 
        35                  40                  45              


Pro Arg Arg Arg Phe Ser Ser Glu Ala Ala Glu Ser Gly Ser Pro Glu 
    50                  55                  60                  


Thr Lys Lys Pro Thr Phe Met Asp Glu Glu Val Gln Ser Ile Leu Thr 
65                  70                  75                  80  


Lys Met Thr Gly Leu Asn Leu Gln Lys Thr Phe Lys Pro Ala Ile Gln 
                85                  90                  95      


Glu Leu Lys Pro Pro Thr Tyr Lys Leu Met Thr Gln Ala Gln Leu Glu 
            100                 105                 110         


Glu Ala Thr Arg Gln Ala Val Glu Ala Ala Lys Val Arg Leu Lys Met 
        115                 120                 125             


Pro Pro Val Leu Glu Glu Arg Val Pro Ile Asn Asp Val Leu Ala Glu 
    130                 135                 140                 


Asp Lys Ile Leu Glu Gly Thr Glu Thr Thr Lys Tyr Val Phe Thr Asp 
145                 150                 155                 160 


Ile Ser Tyr Ser Ile Pro His Arg Glu Arg Phe Ile Val Val Arg Glu 
                165                 170                 175     


Pro Ser Gly Thr Leu Arg Lys Ala Ser Trp Glu Glu Arg Asp Arg Met 
            180                 185                 190         


Ile Gln Val Tyr Phe Pro Lys Glu Gly Arg Lys Ile Leu Thr Pro Ile 
        195                 200                 205             


Ile Phe Lys Glu Glu Asn Leu Arg Val Arg 
    210                 215             

<210>  1772
<211>  1891
<212>  DNA
<213>  Homo sapiens

<400>  1772
aaccacttcc ggcgcaagtg gcttctgata atcatggcgc ccctcggaac aactgtattg     60

ctgtggagcc tcttgaggag ttctccgggc gtggaacggg tctgtttccg ggctcgaatc    120

cagccctggc acggtggcct gctccaaccg ctaccttgct ctttcgagat ggggctgcca    180

cgccgccggt tcagctccga ggccgcagaa tctggtagcc cagagaccaa gaaacctaca    240

tttatggatg aggaagttca aagcatactc acgaaaatga caggcttgaa cttgcagaag    300

acttttaagc cagctataca agaactgaag ccaccaacct ataagctaat gactcaggca    360

cagttggaag aggctacaag acaggcagtt gaggcagcta aagtacgatt aaaaatgcca    420

ccagttctgg aagagcgagt accaataaat gatgtgttag ctgaagataa gattttggaa    480

ggaacagaaa caaccaaata tgtgtttact gatatatcat atagcatacc acaccgggag    540

cgttttattg tcgtcagaga accaagtggc acactacgca aagcctcttg ggaagaacgg    600

gaccgaatga tacaagttta tttcccaaaa gaaggtcgta aaattttgac accaataatt    660

ttcaaggaag aaaatcttag ggtaaggtga cttaggtttt atgttttaga gccagtggtg    720

atgatttatt tgtagaacca gttggctttg tgccttgatc cagataaaca tttctaatga    780

taacttgact tttttttttt tttgaaatgg agtttcgctc cttttgccca ggctgaagtg    840

cagtggcggg atctcagctc actgcaacct ccaccttctg gtttcaagtg attcttctgc    900

ctcagcctca tgagtagctg ggattacagg cgcccgccac cacgcttggc taatttttgt    960

atttttagta gagatggggt ttcaccatgt tggccaggct ggtcttgaac tcctgacctc   1020

gggattcgca cccccccccc gcaatccgac tcccaaagtg ctgggattac aggcgtgagc   1080

caccatgcct ggccgacttc tttcttaata gaatcctcct taccacccaa gatgggttgt   1140

actagggttc tctcataatt ggcttagctg gaatttgaat ctaggtgtga caattacaaa   1200

gcctgtgttc tttctttatg cttcttgagg agcacagagt ggccagtatg tgggtgggca   1260

ggcctgtcat gacatcagga caggtgctga acttcagtgt tctcatgtga tgctaactct   1320

gctgtgtggt tttagactat gtatagccag gacaggcatg ttgatgtcct caatctctgc   1380

tttgcccagt ttgagccaga ttccacagag tatatcaagg ttcatcacaa gacctatgaa   1440

gatatagata aacgtggaaa atatgacctt ttacgttcaa caagatactt tggtggaatg   1500

gtgtggtatt ttgtaaataa taaaaagatt gatggtttgc tgattgacca gattcagaga   1560

gatttaatcg atgatgcaac caacttggtc cagctgtatc acgtgctcca tccagatggc   1620

cagtcggctc aaggggccaa ggatcaggct gctgagggaa taaatttaat caaggtcttt   1680

gcaaaaacag aagcacagaa gggagcctat atagaactaa cactgcagac ttatcaagaa   1740

gcactcagtc gccattctgc agcttcctaa aaatatttta aaaatacatt tattttacta   1800

aatactgact acatttctct gttaatattg agctaaatgt taaaaaatgg ccagattaaa   1860

agatatcaat ttgtagttct ccctacaaag c                                  1891


<210>  1773
<211>  218
<212>  PRT
<213>  Homo sapiens

<400>  1773


Met Ala Pro Leu Gly Thr Thr Val Leu Leu Trp Ser Leu Leu Arg Ser 
1               5                   10                  15      


Ser Pro Gly Val Glu Arg Val Cys Phe Arg Ala Arg Ile Gln Pro Trp 
            20                  25                  30          


His Gly Gly Leu Leu Gln Pro Leu Pro Cys Ser Phe Glu Met Gly Leu 
        35                  40                  45              


Pro Arg Arg Arg Phe Ser Ser Glu Ala Ala Glu Ser Gly Ser Pro Glu 
    50                  55                  60                  


Thr Lys Lys Pro Thr Phe Met Asp Glu Glu Val Gln Ser Ile Leu Thr 
65                  70                  75                  80  


Lys Met Thr Gly Leu Asn Leu Gln Lys Thr Phe Lys Pro Ala Ile Gln 
                85                  90                  95      


Glu Leu Lys Pro Pro Thr Tyr Lys Leu Met Thr Gln Ala Gln Leu Glu 
            100                 105                 110         


Glu Ala Thr Arg Gln Ala Val Glu Ala Ala Lys Val Arg Leu Lys Met 
        115                 120                 125             


Pro Pro Val Leu Glu Glu Arg Val Pro Ile Asn Asp Val Leu Ala Glu 
    130                 135                 140                 


Asp Lys Ile Leu Glu Gly Thr Glu Thr Thr Lys Tyr Val Phe Thr Asp 
145                 150                 155                 160 


Ile Ser Tyr Ser Ile Pro His Arg Glu Arg Phe Ile Val Val Arg Glu 
                165                 170                 175     


Pro Ser Gly Thr Leu Arg Lys Ala Ser Trp Glu Glu Arg Asp Arg Met 
            180                 185                 190         


Ile Gln Val Tyr Phe Pro Lys Glu Gly Arg Lys Ile Leu Thr Pro Ile 
        195                 200                 205             


Ile Phe Lys Glu Glu Asn Leu Arg Val Arg 
    210                 215             

<210>  1774
<211>  2716
<212>  DNA
<213>  Homo sapiens

<400>  1774
aaccacttcc ggcgcaagtg gcttctgata atcatggcgc ccctcggaac aactgtattg     60

ctgtggagcc tcttgaggag ttctccgggc gtggaacggg tctgtttccg ggctcgaatc    120

cagccctggc acggtggcct gctccaaccg ctaccttgct ctttcgagat ggggctgcca    180

cgccgccggt tcagctccga ggccgcagaa tctggtagcc cagagaccaa gaaacctaca    240

tttatggatg aggaagttca aagcatactc acgaaaatga caggcttgaa cttgcagaag    300

acttttaagc cagctataca agaactgaag ccaccaacct ataagctaat gactcaggca    360

cagttggaag aggctacaag acaggcagtt gaggcagcta aagtacgatt aaaaatgcca    420

ccagttctgg aagagcgagt accaataaat gatgtgttag ctgaagataa gattttggaa    480

ggaacagaaa caaccaaata tgtgtttact gatatatcat atagcatacc acaccgggag    540

cgttttattg tcgtcagaga accaagtggc acactacgca aagcctcttg ggaagaacgg    600

gaccgaatga tacaagttta tttcccaaaa gaaggtcgta aaattttgac accaataatt    660

ttcaaggaag aaaatcttag ggtaaggtga cttaggtttt atgttttaga gccagtggtg    720

atgatttatt tgtagaacca gttggctttg tgccttgatc cagataaaca tttctaatga    780

taacttgact tttttttttt tttgaaatgg agtttcgctc cttttgccca ggctgaagtg    840

cagtggcggg atctcagctc actgcaacct ccaccttctg gtttcaagtg attcttctgc    900

ctcagcctca tgagtagctg ggattacagg cgcccgccac cacgcttggc taatttttgt    960

atttttagta gagatggggt ttcaccatgt tggccaggct ggtcttgaac tcctgacctc   1020

gggattcgca cccccccccc gcaatccgac tcccaaagtg ctgggattac aggcgtgagc   1080

caccatgcct ggccgacttc tttcttaata gaatcctcct taccacccaa gatgggttgt   1140

actagggttc tctcataatt ggcttagctg gaatttgaat ctaggtgtga caattacaaa   1200

gcctgtgttc tttctttatg cttcttgagg agcacagagt ggccagtatg tgggtgggca   1260

ggcctgtcat gacatcagga caggtgctga acttcagtgt tctcatgtga tgctaactct   1320

gctgtgtggt tttagactat gtatagccag gacaggcatg ttgatgtcct caatctctgc   1380

tttgcccagt ttgagccaga ttccacagag tatatcaagg ttcatcacaa gacctatgaa   1440

gatatagata aacgtggaaa atatgacctt ttacgttcaa caagatactt tggtggaatg   1500

gtgtggtatt ttgtaaataa taaaaagatt gatggtttgc tgattgacca gattcagaga   1560

gatttaatcg atgatgcaac caacttggtc cagctgtatc acgtgctcca tccagatggc   1620

cagtcggctc aaggggccaa ggatcaggct gctgagggaa taaatttaat caaggtcttt   1680

gcaaaaacag aagcacagaa gggagcctat atagaactaa cactgcagac ttatcaagaa   1740

gcactcagtc gccattctgc agcttcctaa aaatatttta aaaatacatt tattttacta   1800

aatactgact acatttctct gttaatattg agctaaatgt taaaaaatgg ccagattaaa   1860

agatatcaat ttgtagttct ccctacaaag caaaaattat taccctactc acttttcgta   1920

ggctacaagg atatttgagt gcctggttat gaatttctca aatcatgtta gatgagcgta   1980

cggttaaaaa gtctggtgtg tttttgtgtt accaaatagg gcaaacgtta acttagacag   2040

acccccagct taatgaggtc agaggaacag aggtttcaca tcctgactcc agaaatgggt   2100

agctgctaga caaaatcggg gcaagacctg tggaatgatg caatgaggtc aagaaaaagg   2160

gtttagagaa ttacagcctg gatattcagc tctaagaaaa atgtgattga caacatttga   2220

aaatgcagat ttagttatac aaagaaaaga cagtggggct gatccctagg caaggtgtag   2280

tttcggctca gccttctaaa actagaagcc tattttcatt attgagaaag gaaacaagta   2340

ccttcattaa ttcaaaaggt tttatgagat atggtctaat agtatgaaaa aaatcaaagc   2400

ccatgtctgt tttagttaac aaggaaaaca cagtgattta aatgctgcac ataaactctt   2460

cttaagatga tgtgggcatt gtgctcccag tggtccacag catttacata taaaaatcta   2520

agaagtttct catagtccaa agcactgtgg tcagggtagc aatcaatacc tatatataat   2580

aatgatctgt ttagtcaggt aaatggaaag cattacagtc aatcatccaa aatatcttca   2640

tccagattga tatctgttgt gtcaatatct tctaattcca aattatccaa atctacttct   2700

agttcgagta aactct                                                   2716


<210>  1775
<211>  218
<212>  PRT
<213>  Homo sapiens

<400>  1775


Met Ala Pro Leu Gly Thr Thr Val Leu Leu Trp Ser Leu Leu Arg Ser 
1               5                   10                  15      


Ser Pro Gly Val Glu Arg Val Cys Phe Arg Ala Arg Ile Gln Pro Trp 
            20                  25                  30          


His Gly Gly Leu Leu Gln Pro Leu Pro Cys Ser Phe Glu Met Gly Leu 
        35                  40                  45              


Pro Arg Arg Arg Phe Ser Ser Glu Ala Ala Glu Ser Gly Ser Pro Glu 
    50                  55                  60                  


Thr Lys Lys Pro Thr Phe Met Asp Glu Glu Val Gln Ser Ile Leu Thr 
65                  70                  75                  80  


Lys Met Thr Gly Leu Asn Leu Gln Lys Thr Phe Lys Pro Ala Ile Gln 
                85                  90                  95      


Glu Leu Lys Pro Pro Thr Tyr Lys Leu Met Thr Gln Ala Gln Leu Glu 
            100                 105                 110         


Glu Ala Thr Arg Gln Ala Val Glu Ala Ala Lys Val Arg Leu Lys Met 
        115                 120                 125             


Pro Pro Val Leu Glu Glu Arg Val Pro Ile Asn Asp Val Leu Ala Glu 
    130                 135                 140                 


Asp Lys Ile Leu Glu Gly Thr Glu Thr Thr Lys Tyr Val Phe Thr Asp 
145                 150                 155                 160 


Ile Ser Tyr Ser Ile Pro His Arg Glu Arg Phe Ile Val Val Arg Glu 
                165                 170                 175     


Pro Ser Gly Thr Leu Arg Lys Ala Ser Trp Glu Glu Arg Asp Arg Met 
            180                 185                 190         


Ile Gln Val Tyr Phe Pro Lys Glu Gly Arg Lys Ile Leu Thr Pro Ile 
        195                 200                 205             


Ile Phe Lys Glu Glu Asn Leu Arg Val Arg 
    210                 215             

<210>  1776
<211>  2169
<212>  DNA
<213>  Homo sapiens

<400>  1776
aaccacttcc ggcgcaagtg gcttctgata atcatggcgc ccctcggaac aactgtattg     60

ctgtggagcc tcttgaggag ttctccgggc gtggaacggg tctgtttccg ggctcgaatc    120

cagccctggc acggtggcct gctccaaccg ctaccttgct ctttcgagat ggggctgcca    180

cgccgccggt tcagctccga ggccgcagaa tctggtagcc cagagaccaa gaaacctaca    240

tttatggatg aggaagttca aagcatactc acgaaaatga caggcttgaa cttgcagaag    300

acttttaagc cagctataca agaactgaag ccaccaacct ataagctaat gactcaggca    360

cagttggaag aggctacaag acaggcagtt gaggcagcta aagtacgatt aaaaatgcca    420

ccagttctgg aagagcgagt accaataaat gatgtgttag ctgaagataa gattttggaa    480

ggaacagaaa caaccaaata tgtgtttact gatatatcat atagcatacc acaccggtgt    540

tgatggaagt ttcatctatg ttatcttcag aacacattta gagactccta cacctctgaa    600

aacttgagag tcagtactgt ttggttaatt tatacattaa tcaggagcgt tttattgtcg    660

tcagagaacc aagtggcaca ctacgcaaag cctcttggga agaacgggac cgaatgatac    720

aagtttattt cccaaaagaa ggtcgtaaaa ttttgacacc aataattttc aaggaagaaa    780

atcttaggac tatgtatagc caggacaggc atgttgatgt cctcaatctc tgctttgccc    840

agtttgagcc agattccaca gagtatatca aggttcatca caagacctat gaagatatag    900

ataaacgtgg aaaatatgac cttttacgtt caacaagata ctttggtgga atggtgtggt    960

attttgtaaa taataaaaag attgatggtt tgctgattga ccagattcag agagatttaa   1020

tcgatgatgc aaccaacttg gtccagctgt atcacgtgct ccatccagat ggccagtcgg   1080

ctcaaggggc caaggatcag gctgctgagg gaataaattt aatcaaggtc tttgcaaaaa   1140

cagaagcaca gaagggagcc tatatagaac taacactgca gacttatcaa gaagcactca   1200

gtcgccattc tgcagcttcc taaaaatatt ttaaaaatac atttatttta ctaaatactg   1260

actacatttc tctgttaata ttgagctaaa tgttaaaaaa tggccagatt aaaagatatc   1320

aatttgtagt tctccctaca aagcaaaaat tattacccta ctcacttttc gtaggctaca   1380

aggatatttg agtgcctggt tatgaatttc tcaaatcatg ttagatgagc gtacggttaa   1440

aaagtctggt gtgtttttgt gttaccaaat agggcaaacg ttaacttaga cagaccccca   1500

gcttaatgag gtcagaggaa cagaggtttc acatcctgac tccagaaatg ggtagctgct   1560

agacaaaatc ggggcaagac ctgtggaatg atgcaatgag gtcaagaaaa agggtttaga   1620

gaattacagc ctggatattc agctctaaga aaaatgtgat tgacaacatt tgaaaatgca   1680

gatttagtta tacaaagaaa agacagtggg gctgatccct aggcaaggtg tagtttcggc   1740

tcagccttct aaaactagaa gcctattttc attattgaga aaggaaacaa gtaccttcat   1800

taattcaaaa ggttttatga gatatggtct aatagtatga aaaaaatcaa agcccatgtc   1860

tgttttagtt aacaaggaaa acacagtgat ttaaatgctg cacataaact cttcttaaga   1920

tgatgtgggc attgtgctcc cagtggtcca cagcatttac atataaaaat ctaagaagtt   1980

tctcatagtc caaagcactg tggtcagggt agcaatcaat acctatatat aataatgatc   2040

tgtttagtca ggtaaatgga aagcattaca gtcaatcatc caaaatatct tcatccagat   2100

tgatatctgt tgtgtcaata tcttctaatt ccaaattatc caaatctact tctagttcga   2160

gtaaactct                                                           2169


<210>  1777
<211>  169
<212>  PRT
<213>  Homo sapiens

<400>  1777


Met Ala Pro Leu Gly Thr Thr Val Leu Leu Trp Ser Leu Leu Arg Ser 
1               5                   10                  15      


Ser Pro Gly Val Glu Arg Val Cys Phe Arg Ala Arg Ile Gln Pro Trp 
            20                  25                  30          


His Gly Gly Leu Leu Gln Pro Leu Pro Cys Ser Phe Glu Met Gly Leu 
        35                  40                  45              


Pro Arg Arg Arg Phe Ser Ser Glu Ala Ala Glu Ser Gly Ser Pro Glu 
    50                  55                  60                  


Thr Lys Lys Pro Thr Phe Met Asp Glu Glu Val Gln Ser Ile Leu Thr 
65                  70                  75                  80  


Lys Met Thr Gly Leu Asn Leu Gln Lys Thr Phe Lys Pro Ala Ile Gln 
                85                  90                  95      


Glu Leu Lys Pro Pro Thr Tyr Lys Leu Met Thr Gln Ala Gln Leu Glu 
            100                 105                 110         


Glu Ala Thr Arg Gln Ala Val Glu Ala Ala Lys Val Arg Leu Lys Met 
        115                 120                 125             


Pro Pro Val Leu Glu Glu Arg Val Pro Ile Asn Asp Val Leu Ala Glu 
    130                 135                 140                 


Asp Lys Ile Leu Glu Gly Thr Glu Thr Thr Lys Tyr Val Phe Thr Asp 
145                 150                 155                 160 


Ile Ser Tyr Ser Ile Pro His Arg Cys 
                165                 

<210>  1778
<211>  1073
<212>  DNA
<213>  Homo sapiens

<400>  1778
ggcttctgat aatcatggcg cccctcggaa caactgtatt gctgtggagc ctcttgagga     60

gttctccggg cgtggaacgg gtctgtttcc gggctcgaat ccagccctgg cacggtggcc    120

tgctccaacc gctaccttgc tctttcgaga tggggctgcc acgccgccgg ttcagctccg    180

aggccgcaga atctggtagc ccagagacca agaaacctac atttatggat gaggaagttc    240

aaagcatact cacgaaaatg acaggcttga acttgcagaa gacttttaag ccagctatac    300

aagaactgaa gccaccaacc tataagctaa tgactcaggc acagttggaa gaggctacaa    360

gacaggcagt tgaggcagct aaagtacgat taaaaatgcc accagttctg gaagagcgag    420

taccaataaa tgatgtgtta gctgaagata agattttgga aggaacagaa acaaccaaat    480

atgtgtttac tgatatatca tatagcatac cacaccgggt gagtatatgt ctaatcgcaa    540

aatgatcttt ctttgaaata ctatgtggag aagggcttga gagatgatgt gacctggctg    600

tctctgatgc gtccaaacca gatttcctct gactgggtga gacccttctg gaagatatac    660

tatatgaggg atgagaaatg cagaccagcc ccacatcatg gtgttaccat ttctcagcag    720

ataataggca cagtattttc cagattccag atgtgctgag gcagaacaag gagtacacag    780

atacagacag aaacccatcc caaaccacaa atggacaaaa atctacaagg caatggaagc    840

aggagactct tttcgcctaa gttagatgga tttctttagc tgaagctttt tgagaagata    900

gaatgtttct gtcttataaa ttccttgatg atgccaagaa actcaggcat cataaaggat    960

tttcgctttc cagaattttc agtaagaatg acagatgttt ctcagataat tttcaggcat   1020

caccacttct tctgttgtga ttgttattct ctggctcctc tttacttgat tgc          1073


<210>  1779
<211>  176
<212>  PRT
<213>  Homo sapiens

<400>  1779


Met Ala Pro Leu Gly Thr Thr Val Leu Leu Trp Ser Leu Leu Arg Ser 
1               5                   10                  15      


Ser Pro Gly Val Glu Arg Val Cys Phe Arg Ala Arg Ile Gln Pro Trp 
            20                  25                  30          


His Gly Gly Leu Leu Gln Pro Leu Pro Cys Ser Phe Glu Met Gly Leu 
        35                  40                  45              


Pro Arg Arg Arg Phe Ser Ser Glu Ala Ala Glu Ser Gly Ser Pro Glu 
    50                  55                  60                  


Thr Lys Lys Pro Thr Phe Met Asp Glu Glu Val Gln Ser Ile Leu Thr 
65                  70                  75                  80  


Lys Met Thr Gly Leu Asn Leu Gln Lys Thr Phe Lys Pro Ala Ile Gln 
                85                  90                  95      


Glu Leu Lys Pro Pro Thr Tyr Lys Leu Met Thr Gln Ala Gln Leu Glu 
            100                 105                 110         


Glu Ala Thr Arg Gln Ala Val Glu Ala Ala Lys Val Arg Leu Lys Met 
        115                 120                 125             


Pro Pro Val Leu Glu Glu Arg Val Pro Ile Asn Asp Val Leu Ala Glu 
    130                 135                 140                 


Asp Lys Ile Leu Glu Gly Thr Glu Thr Thr Lys Tyr Val Phe Thr Asp 
145                 150                 155                 160 


Ile Ser Tyr Ser Ile Pro His Arg Val Ser Ile Cys Leu Ile Ala Lys 
                165                 170                 175     

<210>  1780
<211>  1149
<212>  DNA
<213>  Homo sapiens

<400>  1780
ggcttctgat aatcatggcg cccctcggaa caactgtatt gctgtggagc ctcttgagga     60

gttctccggg cgtggaacgg gtctgtttcc gggctcgaat ccagccctgg cacggtggcc    120

tgctccaacc gctaccttgc tctttcgaga tggggctgcc acgccgccgg ttcagctccg    180

aggccgcaga atctggtagc ccagagacca agaaacctac atttatggat gaggaagttc    240

aaagcatact cacgaaaatg acaggcttga acttgcagaa gacttttaag ccagctatac    300

aagaactgaa gccaccaacc tataagctaa tgactcaggc acagttggaa gaggctacaa    360

gacaggcagt tgaggcagct aaagtacgat taaaaatgcc accagttctg gaagagcgag    420

taccaataaa tgatgtgtta gctgaagata agattttgga aggaacagaa acaaccaatg    480

gcacactacg caaagcctct tgggaagaac gggaccgaat gatacaagtt tatttcccaa    540

aagaaggtcg taaaattttg acaccaataa ttttcaagga agaaaatctt aggactatgt    600

atagccagga caggcatgtt gatgtcctca atctctgctt tgcccagttt gagccagatt    660

ccacagagta tatcaaggtt catcacaaga cctatgaaga tatagataaa cgtggaaaat    720

atgacctttt acgttcaaca agatactttg gtggaatggt gtggtatttt gtaaataata    780

aaaagattga tggtttgctg attgaccaga ttcagagaga tttaatcgat gatgcaacca    840

acttggtcca gctgtatcac gtgctccatc cagatggcca gtcggctcaa ggggccaagg    900

atcaggctgc tgagggaata aatttaatca aggtctttgc aaaaacagaa gcacagaagg    960

gagcctatat agaactaaca ctgcagactt atcaagaagc actcagtcgc cattctgcag   1020

cttcctaaaa atattttaaa aatacattta ttttactaaa tactgactac atttctctgt   1080

taatattgag ctaaatgtta aaaaatggcc agattaaaag atatcaattt gtagttctcc   1140

ctacaaagc                                                           1149


<210>  1781
<211>  337
<212>  PRT
<213>  Homo sapiens

<400>  1781


Met Ala Pro Leu Gly Thr Thr Val Leu Leu Trp Ser Leu Leu Arg Ser 
1               5                   10                  15      


Ser Pro Gly Val Glu Arg Val Cys Phe Arg Ala Arg Ile Gln Pro Trp 
            20                  25                  30          


His Gly Gly Leu Leu Gln Pro Leu Pro Cys Ser Phe Glu Met Gly Leu 
        35                  40                  45              


Pro Arg Arg Arg Phe Ser Ser Glu Ala Ala Glu Ser Gly Ser Pro Glu 
    50                  55                  60                  


Thr Lys Lys Pro Thr Phe Met Asp Glu Glu Val Gln Ser Ile Leu Thr 
65                  70                  75                  80  


Lys Met Thr Gly Leu Asn Leu Gln Lys Thr Phe Lys Pro Ala Ile Gln 
                85                  90                  95      


Glu Leu Lys Pro Pro Thr Tyr Lys Leu Met Thr Gln Ala Gln Leu Glu 
            100                 105                 110         


Glu Ala Thr Arg Gln Ala Val Glu Ala Ala Lys Val Arg Leu Lys Met 
        115                 120                 125             


Pro Pro Val Leu Glu Glu Arg Val Pro Ile Asn Asp Val Leu Ala Glu 
    130                 135                 140                 


Asp Lys Ile Leu Glu Gly Thr Glu Thr Thr Asn Gly Thr Leu Arg Lys 
145                 150                 155                 160 


Ala Ser Trp Glu Glu Arg Asp Arg Met Ile Gln Val Tyr Phe Pro Lys 
                165                 170                 175     


Glu Gly Arg Lys Ile Leu Thr Pro Ile Ile Phe Lys Glu Glu Asn Leu 
            180                 185                 190         


Arg Thr Met Tyr Ser Gln Asp Arg His Val Asp Val Leu Asn Leu Cys 
        195                 200                 205             


Phe Ala Gln Phe Glu Pro Asp Ser Thr Glu Tyr Ile Lys Val His His 
    210                 215                 220                 


Lys Thr Tyr Glu Asp Ile Asp Lys Arg Gly Lys Tyr Asp Leu Leu Arg 
225                 230                 235                 240 


Ser Thr Arg Tyr Phe Gly Gly Met Val Trp Tyr Phe Val Asn Asn Lys 
                245                 250                 255     


Lys Ile Asp Gly Leu Leu Ile Asp Gln Ile Gln Arg Asp Leu Ile Asp 
            260                 265                 270         


Asp Ala Thr Asn Leu Val Gln Leu Tyr His Val Leu His Pro Asp Gly 
        275                 280                 285             


Gln Ser Ala Gln Gly Ala Lys Asp Gln Ala Ala Glu Gly Ile Asn Leu 
    290                 295                 300                 


Ile Lys Val Phe Ala Lys Thr Glu Ala Gln Lys Gly Ala Tyr Ile Glu 
305                 310                 315                 320 


Leu Thr Leu Gln Thr Tyr Gln Glu Ala Leu Ser Arg His Ser Ala Ala 
                325                 330                 335     


Ser 
    

<210>  1782
<211>  1974
<212>  DNA
<213>  Homo sapiens

<400>  1782
ggcttctgat aatcatggcg cccctcggaa caactgtatt gctgtggagc ctcttgagga     60

gttctccggg cgtggaacgg gtctgtttcc gggctcgaat ccagccctgg cacggtggcc    120

tgctccaacc gctaccttgc tctttcgaga tggggctgcc acgccgccgg ttcagctccg    180

aggccgcaga atctggtagc ccagagacca agaaacctac atttatggat gaggaagttc    240

aaagcatact cacgaaaatg acaggcttga acttgcagaa gacttttaag ccagctatac    300

aagaactgaa gccaccaacc tataagctaa tgactcaggc acagttggaa gaggctacaa    360

gacaggcagt tgaggcagct aaagtacgat taaaaatgcc accagttctg gaagagcgag    420

taccaataaa tgatgtgtta gctgaagata agattttgga aggaacagaa acaaccaatg    480

gcacactacg caaagcctct tgggaagaac gggaccgaat gatacaagtt tatttcccaa    540

aagaaggtcg taaaattttg acaccaataa ttttcaagga agaaaatctt aggactatgt    600

atagccagga caggcatgtt gatgtcctca atctctgctt tgcccagttt gagccagatt    660

ccacagagta tatcaaggtt catcacaaga cctatgaaga tatagataaa cgtggaaaat    720

atgacctttt acgttcaaca agatactttg gtggaatggt gtggtatttt gtaaataata    780

aaaagattga tggtttgctg attgaccaga ttcagagaga tttaatcgat gatgcaacca    840

acttggtcca gctgtatcac gtgctccatc cagatggcca gtcggctcaa ggggccaagg    900

atcaggctgc tgagggaata aatttaatca aggtctttgc aaaaacagaa gcacagaagg    960

gagcctatat agaactaaca ctgcagactt atcaagaagc actcagtcgc cattctgcag   1020

cttcctaaaa atattttaaa aatacattta ttttactaaa tactgactac atttctctgt   1080

taatattgag ctaaatgtta aaaaatggcc agattaaaag atatcaattt gtagttctcc   1140

ctacaaagca aaaattatta ccctactcac ttttcgtagg ctacaaggat atttgagtgc   1200

ctggttatga atttctcaaa tcatgttaga tgagcgtacg gttaaaaagt ctggtgtgtt   1260

tttgtgttac caaatagggc aaacgttaac ttagacagac ccccagctta atgaggtcag   1320

aggaacagag gtttcacatc ctgactccag aaatgggtag ctgctagaca aaatcggggc   1380

aagacctgtg gaatgatgca atgaggtcaa gaaaaagggt ttagagaatt acagcctgga   1440

tattcagctc taagaaaaat gtgattgaca acatttgaaa atgcagattt agttatacaa   1500

agaaaagaca gtggggctga tccctaggca aggtgtagtt tcggctcagc cttctaaaac   1560

tagaagccta ttttcattat tgagaaagga aacaagtacc ttcattaatt caaaaggttt   1620

tatgagatat ggtctaatag tatgaaaaaa atcaaagccc atgtctgttt tagttaacaa   1680

ggaaaacaca gtgatttaaa tgctgcacat aaactcttct taagatgatg tgggcattgt   1740

gctcccagtg gtccacagca tttacatata aaaatctaag aagtttctca tagtccaaag   1800

cactgtggtc agggtagcaa tcaataccta tatataataa tgatctgttt agtcaggtaa   1860

atggaaagca ttacagtcaa tcatccaaaa tatcttcatc cagattgata tctgttgtgt   1920

caatatcttc taattccaaa ttatccaaat ctacttctag ttcgagtaaa ctct         1974


<210>  1783
<211>  337
<212>  PRT
<213>  Homo sapiens

<400>  1783


Met Ala Pro Leu Gly Thr Thr Val Leu Leu Trp Ser Leu Leu Arg Ser 
1               5                   10                  15      


Ser Pro Gly Val Glu Arg Val Cys Phe Arg Ala Arg Ile Gln Pro Trp 
            20                  25                  30          


His Gly Gly Leu Leu Gln Pro Leu Pro Cys Ser Phe Glu Met Gly Leu 
        35                  40                  45              


Pro Arg Arg Arg Phe Ser Ser Glu Ala Ala Glu Ser Gly Ser Pro Glu 
    50                  55                  60                  


Thr Lys Lys Pro Thr Phe Met Asp Glu Glu Val Gln Ser Ile Leu Thr 
65                  70                  75                  80  


Lys Met Thr Gly Leu Asn Leu Gln Lys Thr Phe Lys Pro Ala Ile Gln 
                85                  90                  95      


Glu Leu Lys Pro Pro Thr Tyr Lys Leu Met Thr Gln Ala Gln Leu Glu 
            100                 105                 110         


Glu Ala Thr Arg Gln Ala Val Glu Ala Ala Lys Val Arg Leu Lys Met 
        115                 120                 125             


Pro Pro Val Leu Glu Glu Arg Val Pro Ile Asn Asp Val Leu Ala Glu 
    130                 135                 140                 


Asp Lys Ile Leu Glu Gly Thr Glu Thr Thr Asn Gly Thr Leu Arg Lys 
145                 150                 155                 160 


Ala Ser Trp Glu Glu Arg Asp Arg Met Ile Gln Val Tyr Phe Pro Lys 
                165                 170                 175     


Glu Gly Arg Lys Ile Leu Thr Pro Ile Ile Phe Lys Glu Glu Asn Leu 
            180                 185                 190         


Arg Thr Met Tyr Ser Gln Asp Arg His Val Asp Val Leu Asn Leu Cys 
        195                 200                 205             


Phe Ala Gln Phe Glu Pro Asp Ser Thr Glu Tyr Ile Lys Val His His 
    210                 215                 220                 


Lys Thr Tyr Glu Asp Ile Asp Lys Arg Gly Lys Tyr Asp Leu Leu Arg 
225                 230                 235                 240 


Ser Thr Arg Tyr Phe Gly Gly Met Val Trp Tyr Phe Val Asn Asn Lys 
                245                 250                 255     


Lys Ile Asp Gly Leu Leu Ile Asp Gln Ile Gln Arg Asp Leu Ile Asp 
            260                 265                 270         


Asp Ala Thr Asn Leu Val Gln Leu Tyr His Val Leu His Pro Asp Gly 
        275                 280                 285             


Gln Ser Ala Gln Gly Ala Lys Asp Gln Ala Ala Glu Gly Ile Asn Leu 
    290                 295                 300                 


Ile Lys Val Phe Ala Lys Thr Glu Ala Gln Lys Gly Ala Tyr Ile Glu 
305                 310                 315                 320 


Leu Thr Leu Gln Thr Tyr Gln Glu Ala Leu Ser Arg His Ser Ala Ala 
                325                 330                 335     


Ser 
    

<210>  1784
<211>  1116
<212>  DNA
<213>  Homo sapiens

<400>  1784
actcaaacta ggttggaagg tcagggaagg gttcctggca aatatgacca aagctgagat     60

ctggttagcc atgctaagga gaaagcaaga agcttctcaa gcatagggga cagtagcaga    120

tgtccagaaa tgagactgag cacagatatt tgggaaccca ttttggagca gaatctggta    180

gcccagagac caagaaacct acatttatgg atgaggaagt tcaaagcata ctcacgaaaa    240

tgacaggctt gaacttgcag aagactttta agccagctat acaagaactg aagccaccaa    300

cctataagct aatgactcag gcacagttgg aagaggctac aagacaggca gttgaggcag    360

ctaaagtacg attaaaaatg ccaccagttc tggaagagcg agtaccaata aatgatgtgt    420

tagctgaaga taagattttg gaaggaacag aaacaaccaa atatgtgttt actgatatat    480

catatagcat accacaccgg gagcgtttta ttgtcgtcag agaaccaagt ggcacactac    540

gcaaagcctc ttgggaagaa cgggaccgaa tgatacaagt ttatttccca aaagaaggtc    600

gtaaaatttt gacaccaata attttcaagg aagaaaatct taggactatg tatagccagg    660

acaggcatgt tgatgtcctc aatctctgct ttgcccagtt tgagccagat tccacagagt    720

atatcaaggt tcatcacaag acctatgaag atatagataa acgtggaaaa tatgaccttt    780

tacgttcaac aagatacttt ggtggaatgg tgtggtattt tgtaaataat aaaaagattg    840

atggtttgct gattgaccag attcagagag atttaatcga tgatgcaacc aacttggtcc    900

agctgtatca cgtgctccat ccagatggcc agtcggctca aggggccaag gatcaggctg    960

ctgagggaat aaatttaatc aaggtctttg caaaaacaga agcacagaag ggagcctata   1020

tagaactaac actgcagact tatcaagaag cactcagtcg ccattctgca gcttcctaaa   1080

aatattttaa aaatacattt attttactaa atactg                             1116


<210>  1785
<211>  319
<212>  PRT
<213>  Homo sapiens

<400>  1785


Met Ser Arg Asn Glu Thr Glu His Arg Tyr Leu Gly Thr His Phe Gly 
1               5                   10                  15      


Ala Glu Ser Gly Ser Pro Glu Thr Lys Lys Pro Thr Phe Met Asp Glu 
            20                  25                  30          


Glu Val Gln Ser Ile Leu Thr Lys Met Thr Gly Leu Asn Leu Gln Lys 
        35                  40                  45              


Thr Phe Lys Pro Ala Ile Gln Glu Leu Lys Pro Pro Thr Tyr Lys Leu 
    50                  55                  60                  


Met Thr Gln Ala Gln Leu Glu Glu Ala Thr Arg Gln Ala Val Glu Ala 
65                  70                  75                  80  


Ala Lys Val Arg Leu Lys Met Pro Pro Val Leu Glu Glu Arg Val Pro 
                85                  90                  95      


Ile Asn Asp Val Leu Ala Glu Asp Lys Ile Leu Glu Gly Thr Glu Thr 
            100                 105                 110         


Thr Lys Tyr Val Phe Thr Asp Ile Ser Tyr Ser Ile Pro His Arg Glu 
        115                 120                 125             


Arg Phe Ile Val Val Arg Glu Pro Ser Gly Thr Leu Arg Lys Ala Ser 
    130                 135                 140                 


Trp Glu Glu Arg Asp Arg Met Ile Gln Val Tyr Phe Pro Lys Glu Gly 
145                 150                 155                 160 


Arg Lys Ile Leu Thr Pro Ile Ile Phe Lys Glu Glu Asn Leu Arg Thr 
                165                 170                 175     


Met Tyr Ser Gln Asp Arg His Val Asp Val Leu Asn Leu Cys Phe Ala 
            180                 185                 190         


Gln Phe Glu Pro Asp Ser Thr Glu Tyr Ile Lys Val His His Lys Thr 
        195                 200                 205             


Tyr Glu Asp Ile Asp Lys Arg Gly Lys Tyr Asp Leu Leu Arg Ser Thr 
    210                 215                 220                 


Arg Tyr Phe Gly Gly Met Val Trp Tyr Phe Val Asn Asn Lys Lys Ile 
225                 230                 235                 240 


Asp Gly Leu Leu Ile Asp Gln Ile Gln Arg Asp Leu Ile Asp Asp Ala 
                245                 250                 255     


Thr Asn Leu Val Gln Leu Tyr His Val Leu His Pro Asp Gly Gln Ser 
            260                 265                 270         


Ala Gln Gly Ala Lys Asp Gln Ala Ala Glu Gly Ile Asn Leu Ile Lys 
        275                 280                 285             


Val Phe Ala Lys Thr Glu Ala Gln Lys Gly Ala Tyr Ile Glu Leu Thr 
    290                 295                 300                 


Leu Gln Thr Tyr Gln Glu Ala Leu Ser Arg His Ser Ala Ala Ser 
305                 310                 315                 

<210>  1786
<211>  1200
<212>  DNA
<213>  Homo sapiens

<400>  1786
actcaaacta ggttggaagg tcagggaagg gttcctggca aatatgacca aagctgagat     60

ctggttagcc atgctaagga gaaagcaaga agcttctcaa gcatagggga cagtagcaga    120

tgtccagaaa tgagactgag cacagatatt tgggaaccca ttttggagca gaatctggta    180

gcccagagac caagaaacct acatttatgg atgaggaagt tcaaagcata ctcacgaaaa    240

tgacaggctt gaacttgcag aagactttta agccagctat acaagaactg aagccaccaa    300

cctataagct aatgactcag gcacagttgg aagaggctac aagacaggca gttgaggcag    360

ctaaagtacg attaaaaatg ccaccagttc tggaagagcg agtaccaata aatgatgtgt    420

tagctgaaga taagattttg gaaggaacag aaacaaccaa atatgtgttt actgatatat    480

catatagcat accacaccgg gagcgtttta ttgtcgtcag agaaccaagt ggcacactac    540

gcaaagcctc ttgggaagaa cgggaccgaa tgatacaagt ttatttccca aaagaaggtc    600

gtaaaatttt gacaccaata attttcaagg aagaaaatct taggactatg tatagccagg    660

acaggcatgt tgatgtcctc aatctctgct ttgcccagtt tgagccagat tccacagagt    720

atatcaaggt tcatcacaag acctatgaag atatagataa acgtggaaaa tatgaccttt    780

tacgttcaac aagatacttt ggtggaatgg tgtggtattt tgtaaataat aaaaagattg    840

atggtttgct gattgaccag attcagagag atttaatcga tgatgcaacc aacttggtcc    900

agctgtatca cgtgctccat ccagatggcc agtcggctca aggggccaag gatcaggctg    960

ctgagggaat aaatttaatc aaggtctttg caaaaacaga agcacagaag ggagcctata   1020

tagaactaac actgcagact tatcaagaag cactcagtcg ccattctgca gcttcctaaa   1080

aatattttaa aaatacattt attttactaa atactgacta catttctctg ttaatattga   1140

gctaaatgtt aaaaaatggc cagattaaaa gatatcaatt tgtagttctc cctacaaagc   1200


<210>  1787
<211>  319
<212>  PRT
<213>  Homo sapiens

<400>  1787


Met Ser Arg Asn Glu Thr Glu His Arg Tyr Leu Gly Thr His Phe Gly 
1               5                   10                  15      


Ala Glu Ser Gly Ser Pro Glu Thr Lys Lys Pro Thr Phe Met Asp Glu 
            20                  25                  30          


Glu Val Gln Ser Ile Leu Thr Lys Met Thr Gly Leu Asn Leu Gln Lys 
        35                  40                  45              


Thr Phe Lys Pro Ala Ile Gln Glu Leu Lys Pro Pro Thr Tyr Lys Leu 
    50                  55                  60                  


Met Thr Gln Ala Gln Leu Glu Glu Ala Thr Arg Gln Ala Val Glu Ala 
65                  70                  75                  80  


Ala Lys Val Arg Leu Lys Met Pro Pro Val Leu Glu Glu Arg Val Pro 
                85                  90                  95      


Ile Asn Asp Val Leu Ala Glu Asp Lys Ile Leu Glu Gly Thr Glu Thr 
            100                 105                 110         


Thr Lys Tyr Val Phe Thr Asp Ile Ser Tyr Ser Ile Pro His Arg Glu 
        115                 120                 125             


Arg Phe Ile Val Val Arg Glu Pro Ser Gly Thr Leu Arg Lys Ala Ser 
    130                 135                 140                 


Trp Glu Glu Arg Asp Arg Met Ile Gln Val Tyr Phe Pro Lys Glu Gly 
145                 150                 155                 160 


Arg Lys Ile Leu Thr Pro Ile Ile Phe Lys Glu Glu Asn Leu Arg Thr 
                165                 170                 175     


Met Tyr Ser Gln Asp Arg His Val Asp Val Leu Asn Leu Cys Phe Ala 
            180                 185                 190         


Gln Phe Glu Pro Asp Ser Thr Glu Tyr Ile Lys Val His His Lys Thr 
        195                 200                 205             


Tyr Glu Asp Ile Asp Lys Arg Gly Lys Tyr Asp Leu Leu Arg Ser Thr 
    210                 215                 220                 


Arg Tyr Phe Gly Gly Met Val Trp Tyr Phe Val Asn Asn Lys Lys Ile 
225                 230                 235                 240 


Asp Gly Leu Leu Ile Asp Gln Ile Gln Arg Asp Leu Ile Asp Asp Ala 
                245                 250                 255     


Thr Asn Leu Val Gln Leu Tyr His Val Leu His Pro Asp Gly Gln Ser 
            260                 265                 270         


Ala Gln Gly Ala Lys Asp Gln Ala Ala Glu Gly Ile Asn Leu Ile Lys 
        275                 280                 285             


Val Phe Ala Lys Thr Glu Ala Gln Lys Gly Ala Tyr Ile Glu Leu Thr 
    290                 295                 300                 


Leu Gln Thr Tyr Gln Glu Ala Leu Ser Arg His Ser Ala Ala Ser 
305                 310                 315                 

<210>  1788
<211>  2025
<212>  DNA
<213>  Homo sapiens

<400>  1788
actcaaacta ggttggaagg tcagggaagg gttcctggca aatatgacca aagctgagat     60

ctggttagcc atgctaagga gaaagcaaga agcttctcaa gcatagggga cagtagcaga    120

tgtccagaaa tgagactgag cacagatatt tgggaaccca ttttggagca gaatctggta    180

gcccagagac caagaaacct acatttatgg atgaggaagt tcaaagcata ctcacgaaaa    240

tgacaggctt gaacttgcag aagactttta agccagctat acaagaactg aagccaccaa    300

cctataagct aatgactcag gcacagttgg aagaggctac aagacaggca gttgaggcag    360

ctaaagtacg attaaaaatg ccaccagttc tggaagagcg agtaccaata aatgatgtgt    420

tagctgaaga taagattttg gaaggaacag aaacaaccaa atatgtgttt actgatatat    480

catatagcat accacaccgg gagcgtttta ttgtcgtcag agaaccaagt ggcacactac    540

gcaaagcctc ttgggaagaa cgggaccgaa tgatacaagt ttatttccca aaagaaggtc    600

gtaaaatttt gacaccaata attttcaagg aagaaaatct taggactatg tatagccagg    660

acaggcatgt tgatgtcctc aatctctgct ttgcccagtt tgagccagat tccacagagt    720

atatcaaggt tcatcacaag acctatgaag atatagataa acgtggaaaa tatgaccttt    780

tacgttcaac aagatacttt ggtggaatgg tgtggtattt tgtaaataat aaaaagattg    840

atggtttgct gattgaccag attcagagag atttaatcga tgatgcaacc aacttggtcc    900

agctgtatca cgtgctccat ccagatggcc agtcggctca aggggccaag gatcaggctg    960

ctgagggaat aaatttaatc aaggtctttg caaaaacaga agcacagaag ggagcctata   1020

tagaactaac actgcagact tatcaagaag cactcagtcg ccattctgca gcttcctaaa   1080

aatattttaa aaatacattt attttactaa atactgacta catttctctg ttaatattga   1140

gctaaatgtt aaaaaatggc cagattaaaa gatatcaatt tgtagttctc cctacaaagc   1200

aaaaattatt accctactca cttttcgtag gctacaagga tatttgagtg cctggttatg   1260

aatttctcaa atcatgttag atgagcgtac ggttaaaaag tctggtgtgt ttttgtgtta   1320

ccaaataggg caaacgttaa cttagacaga cccccagctt aatgaggtca gaggaacaga   1380

ggtttcacat cctgactcca gaaatgggta gctgctagac aaaatcgggg caagacctgt   1440

ggaatgatgc aatgaggtca agaaaaaggg tttagagaat tacagcctgg atattcagct   1500

ctaagaaaaa tgtgattgac aacatttgaa aatgcagatt tagttataca aagaaaagac   1560

agtggggctg atccctaggc aaggtgtagt ttcggctcag ccttctaaaa ctagaagcct   1620

attttcatta ttgagaaagg aaacaagtac cttcattaat tcaaaaggtt ttatgagata   1680

tggtctaata gtatgaaaaa aatcaaagcc catgtctgtt ttagttaaca aggaaaacac   1740

agtgatttaa atgctgcaca taaactcttc ttaagatgat gtgggcattg tgctcccagt   1800

ggtccacagc atttacatat aaaaatctaa gaagtttctc atagtccaaa gcactgtggt   1860

cagggtagca atcaatacct atatataata atgatctgtt tagtcaggta aatggaaagc   1920

attacagtca atcatccaaa atatcttcat ccagattgat atctgttgtg tcaatatctt   1980

ctaattccaa attatccaaa tctacttcta gttcgagtaa actct                   2025


<210>  1789
<211>  319
<212>  PRT
<213>  Homo sapiens

<400>  1789


Met Ser Arg Asn Glu Thr Glu His Arg Tyr Leu Gly Thr His Phe Gly 
1               5                   10                  15      


Ala Glu Ser Gly Ser Pro Glu Thr Lys Lys Pro Thr Phe Met Asp Glu 
            20                  25                  30          


Glu Val Gln Ser Ile Leu Thr Lys Met Thr Gly Leu Asn Leu Gln Lys 
        35                  40                  45              


Thr Phe Lys Pro Ala Ile Gln Glu Leu Lys Pro Pro Thr Tyr Lys Leu 
    50                  55                  60                  


Met Thr Gln Ala Gln Leu Glu Glu Ala Thr Arg Gln Ala Val Glu Ala 
65                  70                  75                  80  


Ala Lys Val Arg Leu Lys Met Pro Pro Val Leu Glu Glu Arg Val Pro 
                85                  90                  95      


Ile Asn Asp Val Leu Ala Glu Asp Lys Ile Leu Glu Gly Thr Glu Thr 
            100                 105                 110         


Thr Lys Tyr Val Phe Thr Asp Ile Ser Tyr Ser Ile Pro His Arg Glu 
        115                 120                 125             


Arg Phe Ile Val Val Arg Glu Pro Ser Gly Thr Leu Arg Lys Ala Ser 
    130                 135                 140                 


Trp Glu Glu Arg Asp Arg Met Ile Gln Val Tyr Phe Pro Lys Glu Gly 
145                 150                 155                 160 


Arg Lys Ile Leu Thr Pro Ile Ile Phe Lys Glu Glu Asn Leu Arg Thr 
                165                 170                 175     


Met Tyr Ser Gln Asp Arg His Val Asp Val Leu Asn Leu Cys Phe Ala 
            180                 185                 190         


Gln Phe Glu Pro Asp Ser Thr Glu Tyr Ile Lys Val His His Lys Thr 
        195                 200                 205             


Tyr Glu Asp Ile Asp Lys Arg Gly Lys Tyr Asp Leu Leu Arg Ser Thr 
    210                 215                 220                 


Arg Tyr Phe Gly Gly Met Val Trp Tyr Phe Val Asn Asn Lys Lys Ile 
225                 230                 235                 240 


Asp Gly Leu Leu Ile Asp Gln Ile Gln Arg Asp Leu Ile Asp Asp Ala 
                245                 250                 255     


Thr Asn Leu Val Gln Leu Tyr His Val Leu His Pro Asp Gly Gln Ser 
            260                 265                 270         


Ala Gln Gly Ala Lys Asp Gln Ala Ala Glu Gly Ile Asn Leu Ile Lys 
        275                 280                 285             


Val Phe Ala Lys Thr Glu Ala Gln Lys Gly Ala Tyr Ile Glu Leu Thr 
    290                 295                 300                 


Leu Gln Thr Tyr Gln Glu Ala Leu Ser Arg His Ser Ala Ala Ser 
305                 310                 315                 

<210>  1790
<211>  585
<212>  DNA
<213>  Homo sapiens

<400>  1790
ggcacactac gcaaagcctc ttgggaagaa cgggaccgaa tgatacaagt ttatttccca     60

aaagaaggtc gtaaaatttt gacaccaata attttcaagg aagaaaatct taggactatg    120

tatagccagg acaggcatgt tgatgtcctc aatctctgct ttgcccagtt tgagccagat    180

tccacagagt atatcaaggt tcatcacaag acctatgaag atatagataa acgtggaaaa    240

tatgaccttt tacgttcaac aagatacttt ggtggaatgg tgtggtattt tgtaaataat    300

aaaaagattg atggtttgct gattgaccag attcagagag atttaatcga tgatgcaacc    360

aacttggtcc agctgtatca cgtgctccat ccagatggcc agtcggctca aggggccaag    420

gatcaggctg ctgagggaat aaatttaatc aaggtctttg caaaaacaga agcacagaag    480

ggagcctata tagaactaac actgcagact tatcaagaag cactcagtcg ccattctgca    540

gcttcctaaa aatattttaa aaatacattt attttactaa atact                    585


<210>  1791
<211>  169
<212>  PRT
<213>  Homo sapiens

<400>  1791


Met Ile Gln Val Tyr Phe Pro Lys Glu Gly Arg Lys Ile Leu Thr Pro 
1               5                   10                  15      


Ile Ile Phe Lys Glu Glu Asn Leu Arg Thr Met Tyr Ser Gln Asp Arg 
            20                  25                  30          


His Val Asp Val Leu Asn Leu Cys Phe Ala Gln Phe Glu Pro Asp Ser 
        35                  40                  45              


Thr Glu Tyr Ile Lys Val His His Lys Thr Tyr Glu Asp Ile Asp Lys 
    50                  55                  60                  


Arg Gly Lys Tyr Asp Leu Leu Arg Ser Thr Arg Tyr Phe Gly Gly Met 
65                  70                  75                  80  


Val Trp Tyr Phe Val Asn Asn Lys Lys Ile Asp Gly Leu Leu Ile Asp 
                85                  90                  95      


Gln Ile Gln Arg Asp Leu Ile Asp Asp Ala Thr Asn Leu Val Gln Leu 
            100                 105                 110         


Tyr His Val Leu His Pro Asp Gly Gln Ser Ala Gln Gly Ala Lys Asp 
        115                 120                 125             


Gln Ala Ala Glu Gly Ile Asn Leu Ile Lys Val Phe Ala Lys Thr Glu 
    130                 135                 140                 


Ala Gln Lys Gly Ala Tyr Ile Glu Leu Thr Leu Gln Thr Tyr Gln Glu 
145                 150                 155                 160 


Ala Leu Ser Arg His Ser Ala Ala Ser 
                165                 

<210>  1792
<211>  2258
<212>  DNA
<213>  Homo sapiens

<400>  1792
ggttgtacta gggttctctc ataattggct tagctggaat ttgaatctag gtgtgacaat     60

tacaaagcct gtgttctttc tttatgcttc ttgaggagca cagagtggcc agtatgtggg    120

tgggcaggcc tgtcatgaca tcaggacagg tgctgaactt cagtgttctc atgtgatgct    180

aactctgctg tgtggtttta gactatgtat agccaggaca ggcatgttga tgtcctcaat    240

ctctgctttg cccagtttga gccagattcc acagagtata tcaaggtgag tagattttag    300

tttctaaaat ataggcttaa gtatggttat gagtaagatt tttaatctag ctcaatgaat    360

ttcgttgtaa gttttgatac aggggaaagg gaagagaaat acctgaaaat ctattgagta    420

cagttgtgtg ccagatatat attttataat cacaacaacc cttgattaaa gatgagggaa    480

tttaagcttg tagaattaag tagcttgctg aaagttgcat agctactaag tggtagggtt    540

aggacccaag tttgatgaca aagcctattc tcttttcagt ttaccgtata ggaatcaaat    600

tatttactaa aattttgctg aagtacagtg tgtttgtctt acagctcagt aagtattcat    660

tagtaccttc tatgtgtaag gtattatctt gggtagtata ggtgatgcca cgaactagga    720

tagagtatgc tgtgccaaag ccagcagtcc ggatatggct gtggggaaag gtgctagtaa    780

gtatacaaat aattatctcc tcaggcctaa aatgctagac actaagagaa gattacaaat    840

tctttgaaga aagccttcat aggggtgtaa aggagggttc tagaagtgca ggaaatgttg    900

tggcaggtgg agctgggtga ggtgtttcag gtagagagaa cagtataagc aacaggcagg    960

aaaaaaggag gcttgagaaa cggccagtga tctggtttgc ttatatatgc catgtatatg   1020

taggggagtg attaaagatt aagttaggaa ggtggatgta gccacatcat aggtgacctc   1080

agatgctagg ctgaggaatc tggaattcag tcagcagacc tttgaaagcc ttttgaacag   1140

aggaatgccc ccatcagaac cttcatttag gaagatcaat ctggaaggag gactgaagga   1200

cctttagtta ataagatgga atgggctagc tggtagaata gggtagttga tggggggagg   1260

gataggggaa agggagagta gtgaaaaaat acttgatttc ttttctgcca tagtgaccaa   1320

gaagtgggtg ctacattatt tccagtggtc tctatatgca taatcggtgc ttaataaatt   1380

gtagttggcc tgccaaaaag tacttaatat ggctataaat gtttggtatt ttgcttcagg   1440

ctgccacata cttctacagt ggagaaggca cagacttgct gtcatttaga caaattcttc   1500

tcttttaatt tttttaaaga cagggtctta ttctgtggcc tgccatgccc agctaatttt   1560

ttaaaaaatt ttcctagaga tgaggactgc tcaagcagtc ctcccacctc agcttcccaa   1620

agtgttggga ttataggcat gagccactgt gcctggccaa aattctttct taatagaatc   1680

ctccttccca cctaaggtgg gttgtactag gaatggttta aatcatacca attggttaat   1740

gatatggagg caactgtaag tagacctggt tttacttgct tgggcagcac tcatgctaat   1800

cagtgtacgt tgaataatgc tgcatacttc ttattttcat gtttctgaag agttgcattt   1860

tatgtggata ggttcatcac aagacctatg aagatataga taaacgtgga aaatatgacc   1920

ttttacgttc aacaagatac tttggtggaa tggtgtggta ttttgtaaat aataaaaaga   1980

ttgatggttt gctgattgac cagattcaga gagatttaat cgatgatgca accaacttgg   2040

tccagctgta tcacgtgctc catccagatg gccagtcggc tcaaggggcc aaggatcagg   2100

ctgctgaggg aataaattta atcaaggtct ttgcaaaaac agaagcacag aagggagcct   2160

atatagaact aacactgcag acttatcaag aagcactcag tcgccattct gcagcttcct   2220

aaaaatattt taaaaataca tttattttac taaatact                           2258


<210>  1793
<211>  90
<212>  PRT
<213>  Homo sapiens

<400>  1793


Met Val Trp Tyr Phe Val Asn Asn Lys Lys Ile Asp Gly Leu Leu Ile 
1               5                   10                  15      


Asp Gln Ile Gln Arg Asp Leu Ile Asp Asp Ala Thr Asn Leu Val Gln 
            20                  25                  30          


Leu Tyr His Val Leu His Pro Asp Gly Gln Ser Ala Gln Gly Ala Lys 
        35                  40                  45              


Asp Gln Ala Ala Glu Gly Ile Asn Leu Ile Lys Val Phe Ala Lys Thr 
    50                  55                  60                  


Glu Ala Gln Lys Gly Ala Tyr Ile Glu Leu Thr Leu Gln Thr Tyr Gln 
65                  70                  75                  80  


Glu Ala Leu Ser Arg His Ser Ala Ala Ser 
                85                  90  

<210>  1794
<211>  2343
<212>  DNA
<213>  Homo sapiens

<400>  1794
ggttgtacta gggttctctc ataattggct tagctggaat ttgaatctag gtgtgacaat     60

tacaaagcct gtgttctttc tttatgcttc ttgaggagca cagagtggcc agtatgtggg    120

tgggcaggcc tgtcatgaca tcaggacagg tgctgaactt cagtgttctc atgtgatgct    180

aactctgctg tgtggtttta gactatgtat agccaggaca ggcatgttga tgtcctcaat    240

ctctgctttg cccagtttga gccagattcc acagagtata tcaaggtgag tagattttag    300

tttctaaaat ataggcttaa gtatggttat gagtaagatt tttaatctag ctcaatgaat    360

ttcgttgtaa gttttgatac aggggaaagg gaagagaaat acctgaaaat ctattgagta    420

cagttgtgtg ccagatatat attttataat cacaacaacc cttgattaaa gatgagggaa    480

tttaagcttg tagaattaag tagcttgctg aaagttgcat agctactaag tggtagggtt    540

aggacccaag tttgatgaca aagcctattc tcttttcagt ttaccgtata ggaatcaaat    600

tatttactaa aattttgctg aagtacagtg tgtttgtctt acagctcagt aagtattcat    660

tagtaccttc tatgtgtaag gtattatctt gggtagtata ggtgatgcca cgaactagga    720

tagagtatgc tgtgccaaag ccagcagtcc ggatatggct gtggggaaag gtgctagtaa    780

gtatacaaat aattatctcc tcaggcctaa aatgctagac actaagagaa gattacaaat    840

tctttgaaga aagccttcat aggggtgtaa aggagggttc tagaagtgca ggaaatgttg    900

tggcaggtgg agctgggtga ggtgtttcag gtagagagaa cagtataagc aacaggcagg    960

aaaaaaggag gcttgagaaa cggccagtga tctggtttgc ttatatatgc catgtatatg   1020

taggggagtg attaaagatt aagttaggaa ggtggatgta gccacatcat aggtgacctc   1080

agatgctagg ctgaggaatc tggaattcag tcagcagacc tttgaaagcc ttttgaacag   1140

aggaatgccc ccatcagaac cttcatttag gaagatcaat ctggaaggag gactgaagga   1200

cctttagtta ataagatgga atgggctagc tggtagaata gggtagttga tggggggagg   1260

gataggggaa agggagagta gtgaaaaaat acttgatttc ttttctgcca tagtgaccaa   1320

gaagtgggtg ctacattatt tccagtggtc tctatatgca taatcggtgc ttaataaatt   1380

gtagttggcc tgccaaaaag tacttaatat ggctataaat gtttggtatt ttgcttcagg   1440

ctgccacata cttctacagt ggagaaggca cagacttgct gtcatttaga caaattcttc   1500

tcttttaatt tttttaaaga cagggtctta ttctgtggcc tgccatgccc agctaatttt   1560

ttaaaaaatt ttcctagaga tgaggactgc tcaagcagtc ctcccacctc agcttcccaa   1620

agtgttggga ttataggcat gagccactgt gcctggccaa aattctttct taatagaatc   1680

ctccttccca cctaaggtgg gttgtactag gaatggttta aatcatacca attggttaat   1740

gatatggagg caactgtaag tagacctggt tttacttgct tgggcagcac tcatgctaat   1800

cagtgtacgt tgaataatgc tgcatacttc ttattttcat gtttctgaag agttgcattt   1860

tatgtggata ggttcatcac aagacctatg aagatataga taaacgtgga aaatatgacc   1920

ttttacgttc aacaagatac tttggtggaa tggtgtggta ttttgtaaat aataaaaaga   1980

ttgatggttt gctgattgac cagattcaga gagatttaat cgatgatgca accaacttgg   2040

tccagctgta tcacgtgctc catccagatg gccagtcggc tcaaggggcc aaggatcagg   2100

ctgctgaggg aataaattta atcaaggtct ttgcaaaaac agaagcacag aagggagcct   2160

atatagaact aacactgcag acttatcaag aagcactcag tcgccattct gcagcttcct   2220

aaaaatattt taaaaataca tttattttac taaatactga ctacatttct ctgttaatat   2280

tgagctaaat gttaaaaaat ggccagatta aaagatatca atttgtagtt ctccctacaa   2340

agc                                                                 2343


<210>  1795
<211>  90
<212>  PRT
<213>  Homo sapiens

<400>  1795


Met Val Trp Tyr Phe Val Asn Asn Lys Lys Ile Asp Gly Leu Leu Ile 
1               5                   10                  15      


Asp Gln Ile Gln Arg Asp Leu Ile Asp Asp Ala Thr Asn Leu Val Gln 
            20                  25                  30          


Leu Tyr His Val Leu His Pro Asp Gly Gln Ser Ala Gln Gly Ala Lys 
        35                  40                  45              


Asp Gln Ala Ala Glu Gly Ile Asn Leu Ile Lys Val Phe Ala Lys Thr 
    50                  55                  60                  


Glu Ala Gln Lys Gly Ala Tyr Ile Glu Leu Thr Leu Gln Thr Tyr Gln 
65                  70                  75                  80  


Glu Ala Leu Ser Arg His Ser Ala Ala Ser 
                85                  90  

<210>  1796
<211>  3168
<212>  DNA
<213>  Homo sapiens

<400>  1796
ggttgtacta gggttctctc ataattggct tagctggaat ttgaatctag gtgtgacaat     60

tacaaagcct gtgttctttc tttatgcttc ttgaggagca cagagtggcc agtatgtggg    120

tgggcaggcc tgtcatgaca tcaggacagg tgctgaactt cagtgttctc atgtgatgct    180

aactctgctg tgtggtttta gactatgtat agccaggaca ggcatgttga tgtcctcaat    240

ctctgctttg cccagtttga gccagattcc acagagtata tcaaggtgag tagattttag    300

tttctaaaat ataggcttaa gtatggttat gagtaagatt tttaatctag ctcaatgaat    360

ttcgttgtaa gttttgatac aggggaaagg gaagagaaat acctgaaaat ctattgagta    420

cagttgtgtg ccagatatat attttataat cacaacaacc cttgattaaa gatgagggaa    480

tttaagcttg tagaattaag tagcttgctg aaagttgcat agctactaag tggtagggtt    540

aggacccaag tttgatgaca aagcctattc tcttttcagt ttaccgtata ggaatcaaat    600

tatttactaa aattttgctg aagtacagtg tgtttgtctt acagctcagt aagtattcat    660

tagtaccttc tatgtgtaag gtattatctt gggtagtata ggtgatgcca cgaactagga    720

tagagtatgc tgtgccaaag ccagcagtcc ggatatggct gtggggaaag gtgctagtaa    780

gtatacaaat aattatctcc tcaggcctaa aatgctagac actaagagaa gattacaaat    840

tctttgaaga aagccttcat aggggtgtaa aggagggttc tagaagtgca ggaaatgttg    900

tggcaggtgg agctgggtga ggtgtttcag gtagagagaa cagtataagc aacaggcagg    960

aaaaaaggag gcttgagaaa cggccagtga tctggtttgc ttatatatgc catgtatatg   1020

taggggagtg attaaagatt aagttaggaa ggtggatgta gccacatcat aggtgacctc   1080

agatgctagg ctgaggaatc tggaattcag tcagcagacc tttgaaagcc ttttgaacag   1140

aggaatgccc ccatcagaac cttcatttag gaagatcaat ctggaaggag gactgaagga   1200

cctttagtta ataagatgga atgggctagc tggtagaata gggtagttga tggggggagg   1260

gataggggaa agggagagta gtgaaaaaat acttgatttc ttttctgcca tagtgaccaa   1320

gaagtgggtg ctacattatt tccagtggtc tctatatgca taatcggtgc ttaataaatt   1380

gtagttggcc tgccaaaaag tacttaatat ggctataaat gtttggtatt ttgcttcagg   1440

ctgccacata cttctacagt ggagaaggca cagacttgct gtcatttaga caaattcttc   1500

tcttttaatt tttttaaaga cagggtctta ttctgtggcc tgccatgccc agctaatttt   1560

ttaaaaaatt ttcctagaga tgaggactgc tcaagcagtc ctcccacctc agcttcccaa   1620

agtgttggga ttataggcat gagccactgt gcctggccaa aattctttct taatagaatc   1680

ctccttccca cctaaggtgg gttgtactag gaatggttta aatcatacca attggttaat   1740

gatatggagg caactgtaag tagacctggt tttacttgct tgggcagcac tcatgctaat   1800

cagtgtacgt tgaataatgc tgcatacttc ttattttcat gtttctgaag agttgcattt   1860

tatgtggata ggttcatcac aagacctatg aagatataga taaacgtgga aaatatgacc   1920

ttttacgttc aacaagatac tttggtggaa tggtgtggta ttttgtaaat aataaaaaga   1980

ttgatggttt gctgattgac cagattcaga gagatttaat cgatgatgca accaacttgg   2040

tccagctgta tcacgtgctc catccagatg gccagtcggc tcaaggggcc aaggatcagg   2100

ctgctgaggg aataaattta atcaaggtct ttgcaaaaac agaagcacag aagggagcct   2160

atatagaact aacactgcag acttatcaag aagcactcag tcgccattct gcagcttcct   2220

aaaaatattt taaaaataca tttattttac taaatactga ctacatttct ctgttaatat   2280

tgagctaaat gttaaaaaat ggccagatta aaagatatca atttgtagtt ctccctacaa   2340

agcaaaaatt attaccctac tcacttttcg taggctacaa ggatatttga gtgcctggtt   2400

atgaatttct caaatcatgt tagatgagcg tacggttaaa aagtctggtg tgtttttgtg   2460

ttaccaaata gggcaaacgt taacttagac agacccccag cttaatgagg tcagaggaac   2520

agaggtttca catcctgact ccagaaatgg gtagctgcta gacaaaatcg gggcaagacc   2580

tgtggaatga tgcaatgagg tcaagaaaaa gggtttagag aattacagcc tggatattca   2640

gctctaagaa aaatgtgatt gacaacattt gaaaatgcag atttagttat acaaagaaaa   2700

gacagtgggg ctgatcccta ggcaaggtgt agtttcggct cagccttcta aaactagaag   2760

cctattttca ttattgagaa aggaaacaag taccttcatt aattcaaaag gttttatgag   2820

atatggtcta atagtatgaa aaaaatcaaa gcccatgtct gttttagtta acaaggaaaa   2880

cacagtgatt taaatgctgc acataaactc ttcttaagat gatgtgggca ttgtgctccc   2940

agtggtccac agcatttaca tataaaaatc taagaagttt ctcatagtcc aaagcactgt   3000

ggtcagggta gcaatcaata cctatatata ataatgatct gtttagtcag gtaaatggaa   3060

agcattacag tcaatcatcc aaaatatctt catccagatt gatatctgtt gtgtcaatat   3120

cttctaattc caaattatcc aaatctactt ctagttcgag taaactct                3168


<210>  1797
<211>  90
<212>  PRT
<213>  Homo sapiens

<400>  1797


Met Val Trp Tyr Phe Val Asn Asn Lys Lys Ile Asp Gly Leu Leu Ile 
1               5                   10                  15      


Asp Gln Ile Gln Arg Asp Leu Ile Asp Asp Ala Thr Asn Leu Val Gln 
            20                  25                  30          


Leu Tyr His Val Leu His Pro Asp Gly Gln Ser Ala Gln Gly Ala Lys 
        35                  40                  45              


Asp Gln Ala Ala Glu Gly Ile Asn Leu Ile Lys Val Phe Ala Lys Thr 
    50                  55                  60                  


Glu Ala Gln Lys Gly Ala Tyr Ile Glu Leu Thr Leu Gln Thr Tyr Gln 
65                  70                  75                  80  


Glu Ala Leu Ser Arg His Ser Ala Ala Ser 
                85                  90  

<210>  1798
<211>  5056
<212>  DNA
<213>  Homo sapiens

<400>  1798
agagcacttc atgtgataaa tttggctgag atggttcact tttttttttt ttcttttgag     60

acagagtttc gctccattgc cctggctgga gtgcagtggc gcgatctagg ctcactgcaa    120

gctctgtctc ccgggttcac gccattctcc tgcctcagcc tcccgagtag ctggggtaat    180

tacaggcgcc catcaccggt ccggctaatt tttttgtatt tttattagag acagggtttc    240

actgcattag ccaggatggt ctcgatctcc tgacctcatg atccacctgc ttcggcctcc    300

caaagtgctg ggattacagg cgtgagccac tgtgcctggc tgagatggtt cacttttaaa    360

catcatctcc cacttcctaa ttctgatcat ccttttcttg ggggaaaact ttaaattccc    420

gagtaaattc ccttgtcttc atatatatct tcacttgtgg tttcaggaac ttgatgggaa    480

acctgcttct cctactccgg ttattgtggc ctcccacaca gccaacaaag aagaaaagag    540

tttactcgaa ctagaagtag atttggataa tttggaatta gaagatattg acacaacaga    600

tatcaatctg gatgaagata ttttggatga ttgactgtaa tgctttccat ttacctgact    660

aaacagatca ttattatata taggtattga ttgctaccct gaccacagtg ctttggacta    720

tgagaaactt cttagatttt tatatgtaaa tgctgtggac cactgggagc acaatgccca    780

catcatctta agaagagttt atgtgcagca tttaaatcac tgtgttttcc ttgttaacta    840

aaacagacat gggctttgat ttttttcata ctattagacc atatctcata aaaccttttg    900

aattaatgaa ggtacttgtt tcctttctca ataatgaaaa taggcttcta gttttagaag    960

gctgagccga aactacacct tgcctaggga tcagccccac tgtcttttct ttgtataact   1020

aaatctgcat tttcaaatgt tgtcaatcac atttttctta gagctgaata tccaggctgt   1080

aattctctaa accctttttc ttgacctcat tgcatcattc cacaggtctt gccccgattt   1140

tgtctagcag ctacccattt ctggagtcag gatgtgaaac ctctgttcct ctgacctcat   1200

taagctgggg gtctgtctaa gttaacgttt gccctatttg gtaacacaaa aacacaccag   1260

actttttaac cgtacgctca tctaacatga tttgagaaat tcataaccag gcactcaaat   1320

atccttgtag cctacgaaaa gtgagtaggg taataatttt tgctttgtag ggagaactac   1380

aaattgatat cttttaatct ggccattttt taacatttag ctcaatatta acagagaaat   1440

gtagtcagta tttagtaaaa taaatgtatt tttaaaatat ttttaggaag ctgcagaatg   1500

gcgactgagt gcttcttgat aagtctgcag tgttagttct atataggctc ccttctgtgc   1560

ttctgttttt gcaaagacct gtttaaatta aaaagaaaat tttaaaacaa taggacatat   1620

gctatttata aagtttttca gttttaagac atcattagca tttctgtagt agcaaagagt   1680

cctacttaaa aagggctttc agatttcaca atttttcccc cgattataca ataattaata   1740

aacacacatg gacagaaaaa caatacccaa cacatttcaa gcaatactaa ttctaaacac   1800

cagaagtatc caattaagac cctgacattg tattaatatt aatacttcct tcgagatcaa   1860

aacaaaaacc attaggttag agagaaatct ggaggctaag agttaccaaa ctaacttttg   1920

actttaaaga atattttctc caaaaacatt gcgctttatc aggttcataa agaaaatcag   1980

tactgtagtt tctctctact cttcctagga tgtcatcaca ggtcattgtt tccttagctt   2040

tgcagcatgc aaacagtatt actaggatag aagccagttc cacaaaacca tgtatattct   2100

gagcattaga agagatgaaa ttaattatac aatctcctcc ccttcccttc ctgaaaatat   2160

catctcaact ctcagcactt acagataaat gtacataagc ccatggtttt gagaggtatg   2220

cagctccaaa atgacaatac agctaaggct tgatgatata caagcatcac actctccact   2280

tcttgacaca tgcccatttc ccccgatgtg atgtgaccac acaaagacag gaagctgctc   2340

tgggggacat gtgctactta gtcctctacc ctgtcctgtt ggtggcttga acacctcaga   2400

tgcagctcag cccttccagt gctccaaaga acaaaggggc tgctccctgc actgtcagaa   2460

cttctctgga ctccagctgc tagcaccaca tcactcaacc tactttactg cactttaccc   2520

ccctcccctg tctgtttcta ttgtccaggc tgaagaaata tggggacaaa tcatactgat   2580

gttttcaaga ccacagatgt cccatattca caaatctgtt tagttaccat taattatgac   2640

ccaattctga atttttccca gctcaattac caccacaaaa caaccaatat gaaaaaaaaa   2700

ctttaccttg attaaattta ttccctcagc agcctgatcc ttggcccctt gagccgactg   2760

gccatctgga tggagcacgt gatacagctg gaccaagttg gttgcatcat cgattctgag   2820

aatgaaaggg tttaatgtta tctaggggtt ttcttcattt gattcacagt cctataaaag   2880

tgtgtgccaa cttcaaacta aattacattt cagactttcc tcaggctgga gggattgggg   2940

aaggaccttc agttttacag tttcaaaagc attttcagga aaattgacta atttaggcct   3000

cacaccaact ccgtgaggca gctagggcag gagtcactgc aggaagtgtc caatttatga   3060

aagtgaatat attccaaatg tggctatatt ctttttggaa aaagagcacc atttctcaca   3120

gaaacagcat tcctaatggt agacaatttc caggccagct tacttcacca gcatgtaata   3180

gtctaatcca actcagagga cagaaacaca gcttcatccc acataagcag gagggtggtg   3240

gtcacaggga tctcaaagtc acttgcctct aagtgacatt tgctaacaga caaatgcctc   3300

tacaagaggc cccctaagat tccaaggaaa ggattcacag gaacgcatta gtaaaatagc   3360

atcctagtga agcaaatttg aaattataca cacacatcag acaaaaagga aaatcgggtt   3420

ctacatcagc aatctgtctt aacttcagca tcacacaact acctatgaag aagacagaac   3480

aagaattcag ttcttctggt ctgtacttct cagaaatgta taaacaattt ttatcaacat   3540

taaaactgtc ctagcaaaac caaacaatca ctatcttttc acacagctga cactttccca   3600

ccatttgcca tctcatcgct ggagggcaca gaaaaacgac actcaaaatg cttgtgcttt   3660

tgaggctctg ctatatacac taagtgaact actggcttcc agttgggaat ggagggctga   3720

ggacacccta attcagtgct tccgcagcta gcactcttca gccttccctg cgttcccctt   3780

acctgagctg ggggatgaag agcagggtga cagtgggagt aagtacagaa ttcctcaagc   3840

cttggtagcc ttagagaaat gctctgggct tatactgagg ctcatctacc ctaaaggcca   3900

tctctcagga aaacagagct gttgtatcat aaagcttttc agggggaaaa aaataaaaaa   3960

tgttcatcac aaatctattg tgcttgttat aatctaacaa agtccactaa atgtagtaac   4020

gaaatgtctc cccaataaaa aattaagatt ccctttggag cttaggcatg tggccttata   4080

aagagcttaa ctggactgct acctgttggt atgttcaggg cttcattagg ttcatgctta   4140

agtataatgc ctgtgcctca cagaacaatt taaatttagc ttaacacccc acccatactt   4200

aaagagcaaa taaattatat ttcgaaaaga ttttaaaata atctcaatat aaaaaccaac   4260

agtgggaact gagtctggaa taaatgtgtg cagaatccta attcttttct gagctccact   4320

cagtgaggat atgcaccctc tactgtccag cctgtggttt gcagtaagct cactcttctg   4380

ttcagaatga ccacaggagg gcctttacct aggaatagca ggaaaagcta agtaagtact   4440

caaacttccc tcccagtaag catgaattgc ttcagatgta aagcttacat gtgatgagta   4500

atactataat atcatacatt aatatatcct aataaacttt aattttcaaa catttctgcg   4560

ttgctctaat tttttgtaag aacatactgt tttaataata aagcaatttc agaatgatta   4620

aactcaagaa actttataag tggaaaattc attcacagga gataacgtac ataaagacaa   4680

gtcacttgag catccccatc aacaccagcc cccaattatg gggtatgaag gtatatttct   4740

gccctctgat ttttattaca ctacatatgc tggtgaaatg ggctagcctg gaaatcatca   4800

tcattaggaa tattgtttct atgagaaatg atgccctttt tccaagtatg ggctgatttt   4860

attctgaaaa taagttctgt ggaactttca gttccacatg ccttaccttt gtgtatatgg   4920

tttgtattac atgttaggat actctgcgag tcaaaaacta acagtctgaa ggtggcaata   4980

atctcaaaac tgtcttgtag ttcagacttg agtccagcaa gggctttttg tggaaagttg   5040

actttcttac tacagc                                                   5056


<210>  1799
<211>  80
<212>  PRT
<213>  Homo sapiens

<400>  1799


Met Ile Lys Leu Lys Lys Leu Tyr Lys Trp Lys Ile His Ser Gln Glu 
1               5                   10                  15      


Ile Thr Tyr Ile Lys Thr Ser His Leu Ser Ile Pro Ile Asn Thr Ser 
            20                  25                  30          


Pro Gln Leu Trp Gly Met Lys Val Tyr Phe Cys Pro Leu Ile Phe Ile 
        35                  40                  45              


Thr Leu His Met Leu Val Lys Trp Ala Ser Leu Glu Ile Ile Ile Ile 
    50                  55                  60                  


Arg Asn Ile Val Ser Met Arg Asn Asp Ala Leu Phe Pro Ser Met Gly 
65                  70                  75                  80  

<210>  1800
<211>  4659
<212>  DNA
<213>  Homo sapiens

<400>  1800
aattaagagc tgataaatgt catggaagag ggaaaagact ttcagccctc aagatctaca     60

gctcaacagg aacttgatgg gaaacctgct tctcctactc cggttattgt ggcctcccac    120

acagccaaca aagaagaaaa gagtttactc gaactagaag tagatttgga taatttggaa    180

ttagaagata ttgacacaac agatatcaat ctggatgaag atattttgga tgattgactg    240

taatgctttc catttacctg actaaacaga tcattattat atataggtat tgattgctac    300

cctgaccaca gtgctttgga ctatgagaaa cttcttagat ttttatatgt aaatgctgtg    360

gaccactggg agcacaatgc ccacatcatc ttaagaagag tttatgtgca gcatttaaat    420

cactgtgttt tccttgttaa ctaaaacaga catgggcttt gatttttttc atactattag    480

accatatctc ataaaacctt ttgaattaat gaaggtactt gtttcctttc tcaataatga    540

aaataggctt ctagttttag aaggctgagc cgaaactaca ccttgcctag ggatcagccc    600

cactgtcttt tctttgtata actaaatctg cattttcaaa tgttgtcaat cacatttttc    660

ttagagctga atatccaggc tgtaattctc taaacccttt ttcttgacct cattgcatca    720

ttccacaggt cttgccccga ttttgtctag cagctaccca tttctggagt caggatgtga    780

aacctctgtt cctctgacct cattaagctg ggggtctgtc taagttaacg tttgccctat    840

ttggtaacac aaaaacacac cagacttttt aaccgtacgc tcatctaaca tgatttgaga    900

aattcataac caggcactca aatatccttg tagcctacga aaagtgagta gggtaataat    960

ttttgctttg tagggagaac tacaaattga tatcttttaa tctggccatt ttttaacatt   1020

tagctcaata ttaacagaga aatgtagtca gtatttagta aaataaatgt atttttaaaa   1080

tatttttagg aagctgcaga atggcgactg agtgcttctt gataagtctg cagtgttagt   1140

tctatatagg ctcccttctg tgcttctgtt tttgcaaaga cctgtttaaa ttaaaaagaa   1200

aattttaaaa caataggaca tatgctattt ataaagtttt tcagttttaa gacatcatta   1260

gcatttctgt agtagcaaag agtcctactt aaaaagggct ttcagatttc acaatttttc   1320

ccccgattat acaataatta ataaacacac atggacagaa aaacaatacc caacacattt   1380

caagcaatac taattctaaa caccagaagt atccaattaa gaccctgaca ttgtattaat   1440

attaatactt ccttcgagat caaaacaaaa accattaggt tagagagaaa tctggaggct   1500

aagagttacc aaactaactt ttgactttaa agaatatttt ctccaaaaac attgcgcttt   1560

atcaggttca taaagaaaat cagtactgta gtttctctct actcttccta ggatgtcatc   1620

acaggtcatt gtttccttag ctttgcagca tgcaaacagt attactagga tagaagccag   1680

ttccacaaaa ccatgtatat tctgagcatt agaagagatg aaattaatta tacaatctcc   1740

tccccttccc ttcctgaaaa tatcatctca actctcagca cttacagata aatgtacata   1800

agcccatggt tttgagaggt atgcagctcc aaaatgacaa tacagctaag gcttgatgat   1860

atacaagcat cacactctcc acttcttgac acatgcccat ttcccccgat gtgatgtgac   1920

cacacaaaga caggaagctg ctctggggga catgtgctac ttagtcctct accctgtcct   1980

gttggtggct tgaacacctc agatgcagct cagcccttcc agtgctccaa agaacaaagg   2040

ggctgctccc tgcactgtca gaacttctct ggactccagc tgctagcacc acatcactca   2100

acctacttta ctgcacttta cccccctccc ctgtctgttt ctattgtcca ggctgaagaa   2160

atatggggac aaatcatact gatgttttca agaccacaga tgtcccatat tcacaaatct   2220

gtttagttac cattaattat gacccaattc tgaatttttc ccagctcaat taccaccaca   2280

aaacaaccaa tatgaaaaaa aaactttacc ttgattaaat ttattccctc agcagcctga   2340

tccttggccc cttgagccga ctggccatct ggatggagca cgtgatacag ctggaccaag   2400

ttggttgcat catcgattct gagaatgaaa gggtttaatg ttatctaggg gttttcttca   2460

tttgattcac agtcctataa aagtgtgtgc caacttcaaa ctaaattaca tttcagactt   2520

tcctcaggct ggagggattg gggaaggacc ttcagtttta cagtttcaaa agcattttca   2580

ggaaaattga ctaatttagg cctcacacca actccgtgag gcagctaggg caggagtcac   2640

tgcaggaagt gtccaattta tgaaagtgaa tatattccaa atgtggctat attctttttg   2700

gaaaaagagc accatttctc acagaaacag cattcctaat ggtagacaat ttccaggcca   2760

gcttacttca ccagcatgta atagtctaat ccaactcaga ggacagaaac acagcttcat   2820

cccacataag caggagggtg gtggtcacag ggatctcaaa gtcacttgcc tctaagtgac   2880

atttgctaac agacaaatgc ctctacaaga ggccccctaa gattccaagg aaaggattca   2940

caggaacgca ttagtaaaat agcatcctag tgaagcaaat ttgaaattat acacacacat   3000

cagacaaaaa ggaaaatcgg gttctacatc agcaatctgt cttaacttca gcatcacaca   3060

actacctatg aagaagacag aacaagaatt cagttcttct ggtctgtact tctcagaaat   3120

gtataaacaa tttttatcaa cattaaaact gtcctagcaa aaccaaacaa tcactatctt   3180

ttcacacagc tgacactttc ccaccatttg ccatctcatc gctggagggc acagaaaaac   3240

gacactcaaa atgcttgtgc ttttgaggct ctgctatata cactaagtga actactggct   3300

tccagttggg aatggagggc tgaggacacc ctaattcagt gcttccgcag ctagcactct   3360

tcagccttcc ctgcgttccc cttacctgag ctgggggatg aagagcaggg tgacagtggg   3420

agtaagtaca gaattcctca agccttggta gccttagaga aatgctctgg gcttatactg   3480

aggctcatct accctaaagg ccatctctca ggaaaacaga gctgttgtat cataaagctt   3540

ttcaggggga aaaaaataaa aaatgttcat cacaaatcta ttgtgcttgt tataatctaa   3600

caaagtccac taaatgtagt aacgaaatgt ctccccaata aaaaattaag attccctttg   3660

gagcttaggc atgtggcctt ataaagagct taactggact gctacctgtt ggtatgttca   3720

gggcttcatt aggttcatgc ttaagtataa tgcctgtgcc tcacagaaca atttaaattt   3780

agcttaacac cccacccata cttaaagagc aaataaatta tatttcgaaa agattttaaa   3840

ataatctcaa tataaaaacc aacagtggga actgagtctg gaataaatgt gtgcagaatc   3900

ctaattcttt tctgagctcc actcagtgag gatatgcacc ctctactgtc cagcctgtgg   3960

tttgcagtaa gctcactctt ctgttcagaa tgaccacagg agggccttta cctaggaata   4020

gcaggaaaag ctaagtaagt actcaaactt ccctcccagt aagcatgaat tgcttcagat   4080

gtaaagctta catgtgatga gtaatactat aatatcatac attaatatat cctaataaac   4140

tttaattttc aaacatttct gcgttgctct aattttttgt aagaacatac tgttttaata   4200

ataaagcaat ttcagaatga ttaaactcaa gaaactttat aagtggaaaa ttcattcaca   4260

ggagataacg tacataaaga caagtcactt gagcatcccc atcaacacca gcccccaatt   4320

atggggtatg aaggtatatt tctgccctct gatttttatt acactacata tgctggtgaa   4380

atgggctagc ctggaaatca tcatcattag gaatattgtt tctatgagaa atgatgccct   4440

ttttccaagt atgggctgat tttattctga aaataagttc tgtggaactt tcagttccac   4500

atgccttacc tttgtgtata tggtttgtat tacatgttag gatactctgc gagtcaaaaa   4560

ctaacagtct gaaggtggca ataatctcaa aactgtcttg tagttcagac ttgagtccag   4620

caagggcttt ttgtggaaag ttgactttct tactacagc                          4659


<210>  1801
<211>  71
<212>  PRT
<213>  Homo sapiens

<400>  1801


Met Glu Glu Gly Lys Asp Phe Gln Pro Ser Arg Ser Thr Ala Gln Gln 
1               5                   10                  15      


Glu Leu Asp Gly Lys Pro Ala Ser Pro Thr Pro Val Ile Val Ala Ser 
            20                  25                  30          


His Thr Ala Asn Lys Glu Glu Lys Ser Leu Leu Glu Leu Glu Val Asp 
        35                  40                  45              


Leu Asp Asn Leu Glu Leu Glu Asp Ile Asp Thr Thr Asp Ile Asn Leu 
    50                  55                  60                  


Asp Glu Asp Ile Leu Asp Asp 
65                  70      

<210>  1802
<211>  7273
<212>  DNA
<213>  Homo sapiens

<400>  1802
gactatcgcg agaatcggct cccggaagtt ccacgtcagt cagtctgacg gtcagtggat     60

cggtgggttt atctcaaggc ctgagtagcc ggtaacaaac gagggttccc gggattggac    120

cgacgcagcc atgcctctgc gacttgatat caaaagaaag ctaactgcta gatctgatcg    180

agttaagagt gtggatctgc atcctacaga gccatggatg ttggcaagtc tttacaatgg    240

cagtgtgtgt gtttggaatc atgaaacaca gacactggtg aagacatttg aagtatgtga    300

tcttcctgtt cgagctgcaa agtttgttgc aaggaagaat tgggttgtga caggagcgga    360

tgacatgcag attagagtgt tcaattacaa tactctggag agagttcata tgtttgaagc    420

acactcagac tacattcgct gtattgctgt tcatccaacc cagcctttca ttctaactag    480

cagtgatgac atgcttatta agctctggga ctgggataaa aaatggtctt gctcacaagt    540

gtttgaagga cacacccatt atgttatgca gattgtgatc aaccccaaag ataacaatca    600

gtttgccagt gcctctttgg acaggactat caaggtgtgg cagttgggct cttcgtcacc    660

aaacttcact ttggaaggac atgagaaagg cgtgaattgc attgattact acagtggtgg    720

ggacaagcca tacctcattt caggtgcaga tgaccgtctt gttaaaatat gggattatca    780

gaataaaaca tgtgtgcaga cactggaagg acatgcccaa aatgtgtctt gtgccagctt    840

tcatcctgag ttgccaatca ttatcacagg ttcagaagat ggaacagtac gtatttggca    900

ttcaagcacc taccggcttg agagcacact gaattatgga atggagaggg tatggtgcgt    960

ggccagtcta agagggtcaa acaatgtcgc tttgggctat gatgaaggga gcatcattgt   1020

taagcttggt cgggaggaac ctgccatgtc catggatgcc aatggaaaga taatttgggc   1080

caagcattca gaagtccagc aggccaacct aaaagcaatg ggagatgctg aaattaaaga   1140

tggtgaaaga ttgccactgg cagtaaagga tatgggcagt tgtgaaatat accctcagac   1200

tattcagcac aatcctaatg ggcggtttgt ggtggtgtgt ggtgatgggg agtatatcat   1260

ctacacagca atggcattga gaaacaagag ctttggatct gctcaggagt ttgcatgggc   1320

ccacgattct tcagagtatg caataagaga gagcaacagc attgtaaaga tatttaagaa   1380

ctttaaggaa aaaaaatcat ttaaaccaga ttttggagca gaaagtatct acggcggctt   1440

cttattggga gtcagatctg taaatggctt agccttctat gactgggaca atacagaact   1500

catacgaaga attgaaattc agcccaaaca tattttctgg tctgactctg gagagctagt   1560

ctgtattgct actgaggaat cattttttat ccttaagtat ctgtcagaaa aagtcttggc   1620

tgcacaggaa acacatgagg gagttactga agatggcatt gaagatgcct ttgaggttct   1680

tggtgagatt caggaaattg tgaaaacagg gctttgggta ggcgattgct tcatttacac   1740

aagttctgtg aacagattaa attattatgt tggaggagaa atagtcacca ttgcccactt   1800

ggacaggacg atgtatctcc taggctacat tcctaaagac aacaggcttt atctggggga   1860

taaagaattg aacatcatta gctattccct gctggtttca gtcctggaat accagacagc   1920

tgtcatgcgg agggacttta gcatggctga taaggtcctt cctaccattc caaaagaaca   1980

gaggaccaga gttgcacact ttttggaaaa gcagggcttc aagcagcaag ctcttacagt   2040

atccacagat cctgagcatc gttttgagct tgctcttcag cttggagagt taaaaattgc   2100

ataccagtta gcagtggaag cagagtcaga acagaagtgg aaacaacttg ctgaacttgc   2160

cattagtaaa tgtcagtttg gcctagccca ggagtgcctg catcatgcac aggattatgg   2220

gggcctgctg cttttggcca ctgcctctgg aaatgctaat atggtgaaca agctagcaga   2280

gggtgcggag agagatggca aaaataatgt ggcattcatg agctactttt tacagggcaa   2340

ggttgatgcc tgcctagagc tcttaattag aactggacgg ctgccagaag ctgccttctt   2400

ggcccgaact tacttaccca gtcaggtttc aagggtagtg aaactctgga gagagaatct   2460

ctcaaaagtc aatcagaaag cagcagaatc ccttgctgac ccaacagagt atgaaaacct   2520

gttccctgga ttaaaagaag cctttgttgt tgaagaatgg gtgaaggaaa cacatgctga   2580

tctgtggcca gccaaacaat acccacttgt cacgccaaat gaagagagaa atgtcatgga   2640

agagggaaaa gactttcagc cctcaagatc tacagctcaa caggaacttg atgggaaacc   2700

tgcttctcct actccggtta ttgtggcctc ccacacagcc aacaaagaag aaaagagttt   2760

actcgaacta gaagtagatt tggataattt ggaattagaa gatattgaca caacagatat   2820

caatctggat gaagatattt tggatgattg actgtaatgc tttccattta cctgactaaa   2880

cagatcatta ttatatatag gtattgattg ctaccctgac cacagtgctt tggactatga   2940

gaaacttctt agatttttat atgtaaatgc tgtggaccac tgggagcaca atgcccacat   3000

catcttaaga agagtttatg tgcagcattt aaatcactgt gttttccttg ttaactaaaa   3060

cagacatggg ctttgatttt tttcatacta ttagaccata tctcataaaa ccttttgaat   3120

taatgaaggt acttgtttcc tttctcaata atgaaaatag gcttctagtt ttagaaggct   3180

gagccgaaac tacaccttgc ctagggatca gccccactgt cttttctttg tataactaaa   3240

tctgcatttt caaatgttgt caatcacatt tttcttagag ctgaatatcc aggctgtaat   3300

tctctaaacc ctttttcttg acctcattgc atcattccac aggtcttgcc ccgattttgt   3360

ctagcagcta cccatttctg gagtcaggat gtgaaacctc tgttcctctg acctcattaa   3420

gctgggggtc tgtctaagtt aacgtttgcc ctatttggta acacaaaaac acaccagact   3480

ttttaaccgt acgctcatct aacatgattt gagaaattca taaccaggca ctcaaatatc   3540

cttgtagcct acgaaaagtg agtagggtaa taatttttgc tttgtaggga gaactacaaa   3600

ttgatatctt ttaatctggc cattttttaa catttagctc aatattaaca gagaaatgta   3660

gtcagtattt agtaaaataa atgtattttt aaaatatttt taggaagctg cagaatggcg   3720

actgagtgct tcttgataag tctgcagtgt tagttctata taggctccct tctgtgcttc   3780

tgtttttgca aagacctgtt taaattaaaa agaaaatttt aaaacaatag gacatatgct   3840

atttataaag tttttcagtt ttaagacatc attagcattt ctgtagtagc aaagagtcct   3900

acttaaaaag ggctttcaga tttcacaatt tttcccccga ttatacaata attaataaac   3960

acacatggac agaaaaacaa tacccaacac atttcaagca atactaattc taaacaccag   4020

aagtatccaa ttaagaccct gacattgtat taatattaat acttccttcg agatcaaaac   4080

aaaaaccatt aggttagaga gaaatctgga ggctaagagt taccaaacta acttttgact   4140

ttaaagaata ttttctccaa aaacattgcg ctttatcagg ttcataaaga aaatcagtac   4200

tgtagtttct ctctactctt cctaggatgt catcacaggt cattgtttcc ttagctttgc   4260

agcatgcaaa cagtattact aggatagaag ccagttccac aaaaccatgt atattctgag   4320

cattagaaga gatgaaatta attatacaat ctcctcccct tcccttcctg aaaatatcat   4380

ctcaactctc agcacttaca gataaatgta cataagccca tggttttgag aggtatgcag   4440

ctccaaaatg acaatacagc taaggcttga tgatatacaa gcatcacact ctccacttct   4500

tgacacatgc ccatttcccc cgatgtgatg tgaccacaca aagacaggaa gctgctctgg   4560

gggacatgtg ctacttagtc ctctaccctg tcctgttggt ggcttgaaca cctcagatgc   4620

agctcagccc ttccagtgct ccaaagaaca aaggggctgc tccctgcact gtcagaactt   4680

ctctggactc cagctgctag caccacatca ctcaacctac tttactgcac tttacccccc   4740

tcccctgtct gtttctattg tccaggctga agaaatatgg ggacaaatca tactgatgtt   4800

ttcaagacca cagatgtccc atattcacaa atctgtttag ttaccattaa ttatgaccca   4860

attctgaatt tttcccagct caattaccac cacaaaacaa ccaatatgaa aaaaaaactt   4920

taccttgatt aaatttattc cctcagcagc ctgatccttg gccccttgag ccgactggcc   4980

atctggatgg agcacgtgat acagctggac caagttggtt gcatcatcga ttctgagaat   5040

gaaagggttt aatgttatct aggggttttc ttcatttgat tcacagtcct ataaaagtgt   5100

gtgccaactt caaactaaat tacatttcag actttcctca ggctggaggg attggggaag   5160

gaccttcagt tttacagttt caaaagcatt ttcaggaaaa ttgactaatt taggcctcac   5220

accaactccg tgaggcagct agggcaggag tcactgcagg aagtgtccaa tttatgaaag   5280

tgaatatatt ccaaatgtgg ctatattctt tttggaaaaa gagcaccatt tctcacagaa   5340

acagcattcc taatggtaga caatttccag gccagcttac ttcaccagca tgtaatagtc   5400

taatccaact cagaggacag aaacacagct tcatcccaca taagcaggag ggtggtggtc   5460

acagggatct caaagtcact tgcctctaag tgacatttgc taacagacaa atgcctctac   5520

aagaggcccc ctaagattcc aaggaaagga ttcacaggaa cgcattagta aaatagcatc   5580

ctagtgaagc aaatttgaaa ttatacacac acatcagaca aaaaggaaaa tcgggttcta   5640

catcagcaat ctgtcttaac ttcagcatca cacaactacc tatgaagaag acagaacaag   5700

aattcagttc ttctggtctg tacttctcag aaatgtataa acaattttta tcaacattaa   5760

aactgtccta gcaaaaccaa acaatcacta tcttttcaca cagctgacac tttcccacca   5820

tttgccatct catcgctgga gggcacagaa aaacgacact caaaatgctt gtgcttttga   5880

ggctctgcta tatacactaa gtgaactact ggcttccagt tgggaatgga gggctgagga   5940

caccctaatt cagtgcttcc gcagctagca ctcttcagcc ttccctgcgt tccccttacc   6000

tgagctgggg gatgaagagc agggtgacag tgggagtaag tacagaattc ctcaagcctt   6060

ggtagcctta gagaaatgct ctgggcttat actgaggctc atctacccta aaggccatct   6120

ctcaggaaaa cagagctgtt gtatcataaa gcttttcagg gggaaaaaaa taaaaaatgt   6180

tcatcacaaa tctattgtgc ttgttataat ctaacaaagt ccactaaatg tagtaacgaa   6240

atgtctcccc aataaaaaat taagattccc tttggagctt aggcatgtgg ccttataaag   6300

agcttaactg gactgctacc tgttggtatg ttcagggctt cattaggttc atgcttaagt   6360

ataatgcctg tgcctcacag aacaatttaa atttagctta acaccccacc catacttaaa   6420

gagcaaataa attatatttc gaaaagattt taaaataatc tcaatataaa aaccaacagt   6480

gggaactgag tctggaataa atgtgtgcag aatcctaatt cttttctgag ctccactcag   6540

tgaggatatg caccctctac tgtccagcct gtggtttgca gtaagctcac tcttctgttc   6600

agaatgacca caggagggcc tttacctagg aatagcagga aaagctaagt aagtactcaa   6660

acttccctcc cagtaagcat gaattgcttc agatgtaaag cttacatgtg atgagtaata   6720

ctataatatc atacattaat atatcctaat aaactttaat tttcaaacat ttctgcgttg   6780

ctctaatttt ttgtaagaac atactgtttt aataataaag caatttcaga atgattaaac   6840

tcaagaaact ttataagtgg aaaattcatt cacaggagat aacgtacata aagacaagtc   6900

acttgagcat ccccatcaac accagccccc aattatgggg tatgaaggta tatttctgcc   6960

ctctgatttt tattacacta catatgctgg tgaaatgggc tagcctggaa atcatcatca   7020

ttaggaatat tgtttctatg agaaatgatg ccctttttcc aagtatgggc tgattttatt   7080

ctgaaaataa gttctgtgga actttcagtt ccacatgcct tacctttgtg tatatggttt   7140

gtattacatg ttaggatact ctgcgagtca aaaactaaca gtctgaaggt ggcaataatc   7200

tcaaaactgt cttgtagttc agacttgagt ccagcaaggg ctttttgtgg aaagttgact   7260

ttcttactac agc                                                      7273


<210>  1803
<211>  906
<212>  PRT
<213>  Homo sapiens

<400>  1803


Met Pro Leu Arg Leu Asp Ile Lys Arg Lys Leu Thr Ala Arg Ser Asp 
1               5                   10                  15      


Arg Val Lys Ser Val Asp Leu His Pro Thr Glu Pro Trp Met Leu Ala 
            20                  25                  30          


Ser Leu Tyr Asn Gly Ser Val Cys Val Trp Asn His Glu Thr Gln Thr 
        35                  40                  45              


Leu Val Lys Thr Phe Glu Val Cys Asp Leu Pro Val Arg Ala Ala Lys 
    50                  55                  60                  


Phe Val Ala Arg Lys Asn Trp Val Val Thr Gly Ala Asp Asp Met Gln 
65                  70                  75                  80  


Ile Arg Val Phe Asn Tyr Asn Thr Leu Glu Arg Val His Met Phe Glu 
                85                  90                  95      


Ala His Ser Asp Tyr Ile Arg Cys Ile Ala Val His Pro Thr Gln Pro 
            100                 105                 110         


Phe Ile Leu Thr Ser Ser Asp Asp Met Leu Ile Lys Leu Trp Asp Trp 
        115                 120                 125             


Asp Lys Lys Trp Ser Cys Ser Gln Val Phe Glu Gly His Thr His Tyr 
    130                 135                 140                 


Val Met Gln Ile Val Ile Asn Pro Lys Asp Asn Asn Gln Phe Ala Ser 
145                 150                 155                 160 


Ala Ser Leu Asp Arg Thr Ile Lys Val Trp Gln Leu Gly Ser Ser Ser 
                165                 170                 175     


Pro Asn Phe Thr Leu Glu Gly His Glu Lys Gly Val Asn Cys Ile Asp 
            180                 185                 190         


Tyr Tyr Ser Gly Gly Asp Lys Pro Tyr Leu Ile Ser Gly Ala Asp Asp 
        195                 200                 205             


Arg Leu Val Lys Ile Trp Asp Tyr Gln Asn Lys Thr Cys Val Gln Thr 
    210                 215                 220                 


Leu Glu Gly His Ala Gln Asn Val Ser Cys Ala Ser Phe His Pro Glu 
225                 230                 235                 240 


Leu Pro Ile Ile Ile Thr Gly Ser Glu Asp Gly Thr Val Arg Ile Trp 
                245                 250                 255     


His Ser Ser Thr Tyr Arg Leu Glu Ser Thr Leu Asn Tyr Gly Met Glu 
            260                 265                 270         


Arg Val Trp Cys Val Ala Ser Leu Arg Gly Ser Asn Asn Val Ala Leu 
        275                 280                 285             


Gly Tyr Asp Glu Gly Ser Ile Ile Val Lys Leu Gly Arg Glu Glu Pro 
    290                 295                 300                 


Ala Met Ser Met Asp Ala Asn Gly Lys Ile Ile Trp Ala Lys His Ser 
305                 310                 315                 320 


Glu Val Gln Gln Ala Asn Leu Lys Ala Met Gly Asp Ala Glu Ile Lys 
                325                 330                 335     


Asp Gly Glu Arg Leu Pro Leu Ala Val Lys Asp Met Gly Ser Cys Glu 
            340                 345                 350         


Ile Tyr Pro Gln Thr Ile Gln His Asn Pro Asn Gly Arg Phe Val Val 
        355                 360                 365             


Val Cys Gly Asp Gly Glu Tyr Ile Ile Tyr Thr Ala Met Ala Leu Arg 
    370                 375                 380                 


Asn Lys Ser Phe Gly Ser Ala Gln Glu Phe Ala Trp Ala His Asp Ser 
385                 390                 395                 400 


Ser Glu Tyr Ala Ile Arg Glu Ser Asn Ser Ile Val Lys Ile Phe Lys 
                405                 410                 415     


Asn Phe Lys Glu Lys Lys Ser Phe Lys Pro Asp Phe Gly Ala Glu Ser 
            420                 425                 430         


Ile Tyr Gly Gly Phe Leu Leu Gly Val Arg Ser Val Asn Gly Leu Ala 
        435                 440                 445             


Phe Tyr Asp Trp Asp Asn Thr Glu Leu Ile Arg Arg Ile Glu Ile Gln 
    450                 455                 460                 


Pro Lys His Ile Phe Trp Ser Asp Ser Gly Glu Leu Val Cys Ile Ala 
465                 470                 475                 480 


Thr Glu Glu Ser Phe Phe Ile Leu Lys Tyr Leu Ser Glu Lys Val Leu 
                485                 490                 495     


Ala Ala Gln Glu Thr His Glu Gly Val Thr Glu Asp Gly Ile Glu Asp 
            500                 505                 510         


Ala Phe Glu Val Leu Gly Glu Ile Gln Glu Ile Val Lys Thr Gly Leu 
        515                 520                 525             


Trp Val Gly Asp Cys Phe Ile Tyr Thr Ser Ser Val Asn Arg Leu Asn 
    530                 535                 540                 


Tyr Tyr Val Gly Gly Glu Ile Val Thr Ile Ala His Leu Asp Arg Thr 
545                 550                 555                 560 


Met Tyr Leu Leu Gly Tyr Ile Pro Lys Asp Asn Arg Leu Tyr Leu Gly 
                565                 570                 575     


Asp Lys Glu Leu Asn Ile Ile Ser Tyr Ser Leu Leu Val Ser Val Leu 
            580                 585                 590         


Glu Tyr Gln Thr Ala Val Met Arg Arg Asp Phe Ser Met Ala Asp Lys 
        595                 600                 605             


Val Leu Pro Thr Ile Pro Lys Glu Gln Arg Thr Arg Val Ala His Phe 
    610                 615                 620                 


Leu Glu Lys Gln Gly Phe Lys Gln Gln Ala Leu Thr Val Ser Thr Asp 
625                 630                 635                 640 


Pro Glu His Arg Phe Glu Leu Ala Leu Gln Leu Gly Glu Leu Lys Ile 
                645                 650                 655     


Ala Tyr Gln Leu Ala Val Glu Ala Glu Ser Glu Gln Lys Trp Lys Gln 
            660                 665                 670         


Leu Ala Glu Leu Ala Ile Ser Lys Cys Gln Phe Gly Leu Ala Gln Glu 
        675                 680                 685             


Cys Leu His His Ala Gln Asp Tyr Gly Gly Leu Leu Leu Leu Ala Thr 
    690                 695                 700                 


Ala Ser Gly Asn Ala Asn Met Val Asn Lys Leu Ala Glu Gly Ala Glu 
705                 710                 715                 720 


Arg Asp Gly Lys Asn Asn Val Ala Phe Met Ser Tyr Phe Leu Gln Gly 
                725                 730                 735     


Lys Val Asp Ala Cys Leu Glu Leu Leu Ile Arg Thr Gly Arg Leu Pro 
            740                 745                 750         


Glu Ala Ala Phe Leu Ala Arg Thr Tyr Leu Pro Ser Gln Val Ser Arg 
        755                 760                 765             


Val Val Lys Leu Trp Arg Glu Asn Leu Ser Lys Val Asn Gln Lys Ala 
    770                 775                 780                 


Ala Glu Ser Leu Ala Asp Pro Thr Glu Tyr Glu Asn Leu Phe Pro Gly 
785                 790                 795                 800 


Leu Lys Glu Ala Phe Val Val Glu Glu Trp Val Lys Glu Thr His Ala 
                805                 810                 815     


Asp Leu Trp Pro Ala Lys Gln Tyr Pro Leu Val Thr Pro Asn Glu Glu 
            820                 825                 830         


Arg Asn Val Met Glu Glu Gly Lys Asp Phe Gln Pro Ser Arg Ser Thr 
        835                 840                 845             


Ala Gln Gln Glu Leu Asp Gly Lys Pro Ala Ser Pro Thr Pro Val Ile 
    850                 855                 860                 


Val Ala Ser His Thr Ala Asn Lys Glu Glu Lys Ser Leu Leu Glu Leu 
865                 870                 875                 880 


Glu Val Asp Leu Asp Asn Leu Glu Leu Glu Asp Ile Asp Thr Thr Asp 
                885                 890                 895     


Ile Asn Leu Asp Glu Asp Ile Leu Asp Asp 
            900                 905     

<210>  1804
<211>  4551
<212>  DNA
<213>  Homo sapiens

<400>  1804
agagcacttc atgtgataaa tttggctgag atggttcact tttttttttt ttcttttgag     60

acagagtttc gctccattgc cctggctgga gtgcagtggc gcgatctagg ctcactgcaa    120

gctctgtctc ccgggttcac gccattctcc tgcctcagcc tcccgagtag ctggggtaat    180

tacaggcgcc catcaccggt ccggctaatt tttttgtatt tttattagag acagggtttc    240

actgcattag ccaggatggt ctcgatctcc tgacctcatg atccacctgc ttcggcctcc    300

caaagtgctg ggattacagg cgtgagccac tgtgcctggc tgagatggtt cacttttaaa    360

catcatctcc cacttcctaa ttctgatcat ccttttcttg ggggaaaact ttaaattccc    420

gagtaaattc ccttgtcttc atatatatct tcacttgtgg tttcaggaac ttgatgggaa    480

acctgcttct cctactccgg ttattgtggc ctcccacaca gccaacaaag aagaaaagag    540

tttactcgaa ctagaagtag atttggataa tttggaatta gaagatattg acacaacaga    600

tatcaatctg gatgaagata ttttggatga ttgactgtaa tgctttccat ttacctgact    660

aaacagatca ttattatata taggtattga ttgctaccct gaccacagtg ctttggacta    720

tgagaaactt cttagatttt tatatgtaaa tgctgtggac cactgggagc acaatgccca    780

catcatctta agaagagttt atgtgcagca tttaaatcac tgtgttttcc ttgttaacta    840

aaacagacat gggctttgat ttttttcata ctattagacc atatctcata aaaccttttg    900

aattaatgaa ggtacttgtt tcctttctca ataatgaaaa taggcttcta gttttagaag    960

gctgagccga aactacacct tgcctaggga tcagccccac tgtcttttct ttgtataact   1020

aaatctgcat tttcaaatgt tgtcaatcac atttttctta gagctgaata tccaggctgt   1080

aattctctaa accctttttc ttgacctcat tgcatcattc cacaggtctt gccccgattt   1140

tgtctagcag ctacccattt ctggagtcag gatgtgaaac ctctgttcct ctgacctcat   1200

taagctgggg gtctgtctaa gttaacgttt gccctatttg gtaacacaaa aacacaccag   1260

actttttaac cgtacgctca tctaacatga tttgagaaat tcataaccag gcactcaaat   1320

atccttgtag cctacgaaaa gtgagtaggg taataatttt tgctttgtag ggagaactac   1380

aaattgatat cttttaatct ggccattttt taacatttag ctcaatatta acagagaaat   1440

gtagtcagta tttagtaaaa taaatgtatt tttaaaatat ttttaggaag ctgcagaatg   1500

gcgactgagt gcttcttgat aagtctgcag tgttagttct atataggctc ccttctgtgc   1560

ttctgttttt gcaaagacct gtttaaatta aaaagaaaat tttaaaacaa taggacatat   1620

gctatttata aagtttttca gttttaagac atcattagca tttctgtagt agcaaagagt   1680

cctacttaaa aagggctttc agatttcaca atttttcccc cgattataca ataattaata   1740

aacacacatg gacagaaaaa caatacccaa cacatttcaa gcaatactaa ttctaaacac   1800

cagaagtatc caattaagac cctgacattg tattaatatt aatacttcct tcgagatcaa   1860

aacaaaaacc attaggttag agagaaatct ggaggctaag agttaccaaa ctaacttttg   1920

actttaaaga atattttctc caaaaacatt gcgctttatc aggttcataa agaaaatcag   1980

tactgtagtt tctctctact cttcctagga tgtcatcaca ggtcattgtt tccttagctt   2040

tgcagcatgc aaacagtatt actaggatag aagccagttc cacaaaacca tgtatattct   2100

gagcattaga agagatgaaa ttaattatac aatctcctcc ccttcccttc ctgaaaatat   2160

catctcaact ctcagcactt acagataaat gtacataagc ccatggtttt gagaggtatg   2220

cagctccaaa atgacaatac agctaaggct tgatgatata caagcatcac actctccact   2280

tcttgacaca tgcccatttc ccccgatgtg atgtgaccac acaaagacag gaagctgctc   2340

tgggggacat gtgctactta gtcctctacc ctgtcctgtt ggtggcttga acacctcaga   2400

tgcagctcag cccttccagt gctccaaaga acaaaggggc tgctccctgc actgtcagaa   2460

cttctctgga ctccagctgc tagcaccaca tcactcaacc tactttactg cactttaccc   2520

ccctcccctg tctgtttcta ttgtccaggc tgaagaaata tggggacaaa tcatactgat   2580

gttttcaaga ccacagatgt cccatattca caaatctgtt tagttaccat taattatgac   2640

ccaattctga atttttccca gctcaattac caccacaaaa caaccaatat gaaaaaaaaa   2700

ctttaccttg attaaattta ttccctcagc agcctgatcc ttggcccctt gagccgactg   2760

gccatctgga tggagcacgt gatacagctg gaccaagttg gttgcatcat cgattctgag   2820

aatgaaaggg tttaatgtta tctaggggtt ttcttcattt gattcacagt cctataaaag   2880

tgtgtgccaa cttcaaacta aattacattt cagactttcc tcaggctgga gggattgggg   2940

aaggaccttc agttttacag tttcaaaagc attttcagga aaattgacta atttaggcct   3000

cacaccaact ccgtgaggca gctagggcag gagtcactgc aggaagtgtc caatttatga   3060

aagtgaatat attccaaatg tggctatatt ctttttggaa aaagagcacc atttctcaca   3120

gaaacagcat tcctaatggt agacaatttc caggccagct tacttcacca gcatgtaata   3180

gtctaatcca actcagagga cagaaacaca gcttcatccc acataagcag gagggtggtg   3240

gtcacaggga tctcaaagtc acttgcctct aagtgacatt tgctaacaga caaatgcctc   3300

tacaagaggc cccctaagat tccaaggaaa ggattcacag gaacgcatta gtaaaatagc   3360

atcctagtga agcaaatttg aaattataca cacacatcag acaaaaagga aaatcgggtt   3420

ctacatcagc aatctgtctt aacttcagca tcacacaact acctatgaag aagacagaac   3480

aagaattcag ttcttctggt ctgtacttct cagaaatgta taaacaattt ttatcaacat   3540

taaaactgtc ctagcaaaac caaacaatca ctatcttttc acacagctga cactttccca   3600

ccatttgcca tctcatcgct ggagggcaca gaaaaacgac actcaaaatg cttgtgcttt   3660

tgaggctctg ctatatacac taagtgaact actggcttcc agttgggaat ggagggctga   3720

ggacacccta attcagtgct tccgcagcta gcactcttca gccttccctg cgttcccctt   3780

acctgagctg ggggatgaag agcagggtga cagtgggagt aagtacagaa ttcctcaagc   3840

cttggtagcc ttagagaaat gctctgggct tatactgagg ctcatctacc ctaaaggcca   3900

tctctcagga aaacagagct gttgtatcat aaagcttttc agggggaaaa aaataaaaaa   3960

tgttcatcac aaatctattg tgcttgttat aatctaacaa agtccactaa atgtagtaac   4020

gaaatgtctc cccaataaaa aattaagatt ccctttggag cttaggcatg tggccttata   4080

aagagcttaa ctggactgct acctgttggt atgttcaggg cttcattagg ttcatgctta   4140

agtataatgc ctgtgcctca cagaacaatt taaatttagc ttaacacccc acccatactt   4200

aaagagcaaa taaattatat ttcgaaaaga ttttaaaata atctcaatat aaaaaccaac   4260

agtgggaact gagtctggaa taaatgtgtg cagaatccta attcttttct gagctccact   4320

cagtgaggat atgcaccctc tactgtccag cctgtggttt gcagtaagct cactcttctg   4380

ttcagaatga ccacaggagg gcctttacct aggaatagca ggaaaagcta agtaagtact   4440

caaacttccc tcccagtaag catgaattgc ttcagatgta aagcttacat gtgatgagta   4500

atactataat atcatacatt aatatatcct aataaacttt aattttcaaa c            4551


<210>  1805
<211>  71
<212>  PRT
<213>  Homo sapiens

<400>  1805


Met Lys Val Asn Ile Phe Gln Met Trp Leu Tyr Ser Phe Trp Lys Lys 
1               5                   10                  15      


Ser Thr Ile Ser His Arg Asn Ser Ile Pro Asn Gly Arg Gln Phe Pro 
            20                  25                  30          


Gly Gln Leu Thr Ser Pro Ala Cys Asn Ser Leu Ile Gln Leu Arg Gly 
        35                  40                  45              


Gln Lys His Ser Phe Ile Pro His Lys Gln Glu Gly Gly Gly His Arg 
    50                  55                  60                  


Asp Leu Lys Val Thr Cys Leu 
65                  70      

<210>  1806
<211>  4154
<212>  DNA
<213>  Homo sapiens

<400>  1806
aattaagagc tgataaatgt catggaagag ggaaaagact ttcagccctc aagatctaca     60

gctcaacagg aacttgatgg gaaacctgct tctcctactc cggttattgt ggcctcccac    120

acagccaaca aagaagaaaa gagtttactc gaactagaag tagatttgga taatttggaa    180

ttagaagata ttgacacaac agatatcaat ctggatgaag atattttgga tgattgactg    240

taatgctttc catttacctg actaaacaga tcattattat atataggtat tgattgctac    300

cctgaccaca gtgctttgga ctatgagaaa cttcttagat ttttatatgt aaatgctgtg    360

gaccactggg agcacaatgc ccacatcatc ttaagaagag tttatgtgca gcatttaaat    420

cactgtgttt tccttgttaa ctaaaacaga catgggcttt gatttttttc atactattag    480

accatatctc ataaaacctt ttgaattaat gaaggtactt gtttcctttc tcaataatga    540

aaataggctt ctagttttag aaggctgagc cgaaactaca ccttgcctag ggatcagccc    600

cactgtcttt tctttgtata actaaatctg cattttcaaa tgttgtcaat cacatttttc    660

ttagagctga atatccaggc tgtaattctc taaacccttt ttcttgacct cattgcatca    720

ttccacaggt cttgccccga ttttgtctag cagctaccca tttctggagt caggatgtga    780

aacctctgtt cctctgacct cattaagctg ggggtctgtc taagttaacg tttgccctat    840

ttggtaacac aaaaacacac cagacttttt aaccgtacgc tcatctaaca tgatttgaga    900

aattcataac caggcactca aatatccttg tagcctacga aaagtgagta gggtaataat    960

ttttgctttg tagggagaac tacaaattga tatcttttaa tctggccatt ttttaacatt   1020

tagctcaata ttaacagaga aatgtagtca gtatttagta aaataaatgt atttttaaaa   1080

tatttttagg aagctgcaga atggcgactg agtgcttctt gataagtctg cagtgttagt   1140

tctatatagg ctcccttctg tgcttctgtt tttgcaaaga cctgtttaaa ttaaaaagaa   1200

aattttaaaa caataggaca tatgctattt ataaagtttt tcagttttaa gacatcatta   1260

gcatttctgt agtagcaaag agtcctactt aaaaagggct ttcagatttc acaatttttc   1320

ccccgattat acaataatta ataaacacac atggacagaa aaacaatacc caacacattt   1380

caagcaatac taattctaaa caccagaagt atccaattaa gaccctgaca ttgtattaat   1440

attaatactt ccttcgagat caaaacaaaa accattaggt tagagagaaa tctggaggct   1500

aagagttacc aaactaactt ttgactttaa agaatatttt ctccaaaaac attgcgcttt   1560

atcaggttca taaagaaaat cagtactgta gtttctctct actcttccta ggatgtcatc   1620

acaggtcatt gtttccttag ctttgcagca tgcaaacagt attactagga tagaagccag   1680

ttccacaaaa ccatgtatat tctgagcatt agaagagatg aaattaatta tacaatctcc   1740

tccccttccc ttcctgaaaa tatcatctca actctcagca cttacagata aatgtacata   1800

agcccatggt tttgagaggt atgcagctcc aaaatgacaa tacagctaag gcttgatgat   1860

atacaagcat cacactctcc acttcttgac acatgcccat ttcccccgat gtgatgtgac   1920

cacacaaaga caggaagctg ctctggggga catgtgctac ttagtcctct accctgtcct   1980

gttggtggct tgaacacctc agatgcagct cagcccttcc agtgctccaa agaacaaagg   2040

ggctgctccc tgcactgtca gaacttctct ggactccagc tgctagcacc acatcactca   2100

acctacttta ctgcacttta cccccctccc ctgtctgttt ctattgtcca ggctgaagaa   2160

atatggggac aaatcatact gatgttttca agaccacaga tgtcccatat tcacaaatct   2220

gtttagttac cattaattat gacccaattc tgaatttttc ccagctcaat taccaccaca   2280

aaacaaccaa tatgaaaaaa aaactttacc ttgattaaat ttattccctc agcagcctga   2340

tccttggccc cttgagccga ctggccatct ggatggagca cgtgatacag ctggaccaag   2400

ttggttgcat catcgattct gagaatgaaa gggtttaatg ttatctaggg gttttcttca   2460

tttgattcac agtcctataa aagtgtgtgc caacttcaaa ctaaattaca tttcagactt   2520

tcctcaggct ggagggattg gggaaggacc ttcagtttta cagtttcaaa agcattttca   2580

ggaaaattga ctaatttagg cctcacacca actccgtgag gcagctaggg caggagtcac   2640

tgcaggaagt gtccaattta tgaaagtgaa tatattccaa atgtggctat attctttttg   2700

gaaaaagagc accatttctc acagaaacag cattcctaat ggtagacaat ttccaggcca   2760

gcttacttca ccagcatgta atagtctaat ccaactcaga ggacagaaac acagcttcat   2820

cccacataag caggagggtg gtggtcacag ggatctcaaa gtcacttgcc tctaagtgac   2880

atttgctaac agacaaatgc ctctacaaga ggccccctaa gattccaagg aaaggattca   2940

caggaacgca ttagtaaaat agcatcctag tgaagcaaat ttgaaattat acacacacat   3000

cagacaaaaa ggaaaatcgg gttctacatc agcaatctgt cttaacttca gcatcacaca   3060

actacctatg aagaagacag aacaagaatt cagttcttct ggtctgtact tctcagaaat   3120

gtataaacaa tttttatcaa cattaaaact gtcctagcaa aaccaaacaa tcactatctt   3180

ttcacacagc tgacactttc ccaccatttg ccatctcatc gctggagggc acagaaaaac   3240

gacactcaaa atgcttgtgc ttttgaggct ctgctatata cactaagtga actactggct   3300

tccagttggg aatggagggc tgaggacacc ctaattcagt gcttccgcag ctagcactct   3360

tcagccttcc ctgcgttccc cttacctgag ctgggggatg aagagcaggg tgacagtggg   3420

agtaagtaca gaattcctca agccttggta gccttagaga aatgctctgg gcttatactg   3480

aggctcatct accctaaagg ccatctctca ggaaaacaga gctgttgtat cataaagctt   3540

ttcaggggga aaaaaataaa aaatgttcat cacaaatcta ttgtgcttgt tataatctaa   3600

caaagtccac taaatgtagt aacgaaatgt ctccccaata aaaaattaag attccctttg   3660

gagcttaggc atgtggcctt ataaagagct taactggact gctacctgtt ggtatgttca   3720

gggcttcatt aggttcatgc ttaagtataa tgcctgtgcc tcacagaaca atttaaattt   3780

agcttaacac cccacccata cttaaagagc aaataaatta tatttcgaaa agattttaaa   3840

ataatctcaa tataaaaacc aacagtggga actgagtctg gaataaatgt gtgcagaatc   3900

ctaattcttt tctgagctcc actcagtgag gatatgcacc ctctactgtc cagcctgtgg   3960

tttgcagtaa gctcactctt ctgttcagaa tgaccacagg agggccttta cctaggaata   4020

gcaggaaaag ctaagtaagt actcaaactt ccctcccagt aagcatgaat tgcttcagat   4080

gtaaagctta catgtgatga gtaatactat aatatcatac attaatatat cctaataaac   4140

tttaattttc aaac                                                     4154


<210>  1807
<211>  71
<212>  PRT
<213>  Homo sapiens

<400>  1807


Met Glu Glu Gly Lys Asp Phe Gln Pro Ser Arg Ser Thr Ala Gln Gln 
1               5                   10                  15      


Glu Leu Asp Gly Lys Pro Ala Ser Pro Thr Pro Val Ile Val Ala Ser 
            20                  25                  30          


His Thr Ala Asn Lys Glu Glu Lys Ser Leu Leu Glu Leu Glu Val Asp 
        35                  40                  45              


Leu Asp Asn Leu Glu Leu Glu Asp Ile Asp Thr Thr Asp Ile Asn Leu 
    50                  55                  60                  


Asp Glu Asp Ile Leu Asp Asp 
65                  70      

<210>  1808
<211>  6768
<212>  DNA
<213>  Homo sapiens

<400>  1808
gactatcgcg agaatcggct cccggaagtt ccacgtcagt cagtctgacg gtcagtggat     60

cggtgggttt atctcaaggc ctgagtagcc ggtaacaaac gagggttccc gggattggac    120

cgacgcagcc atgcctctgc gacttgatat caaaagaaag ctaactgcta gatctgatcg    180

agttaagagt gtggatctgc atcctacaga gccatggatg ttggcaagtc tttacaatgg    240

cagtgtgtgt gtttggaatc atgaaacaca gacactggtg aagacatttg aagtatgtga    300

tcttcctgtt cgagctgcaa agtttgttgc aaggaagaat tgggttgtga caggagcgga    360

tgacatgcag attagagtgt tcaattacaa tactctggag agagttcata tgtttgaagc    420

acactcagac tacattcgct gtattgctgt tcatccaacc cagcctttca ttctaactag    480

cagtgatgac atgcttatta agctctggga ctgggataaa aaatggtctt gctcacaagt    540

gtttgaagga cacacccatt atgttatgca gattgtgatc aaccccaaag ataacaatca    600

gtttgccagt gcctctttgg acaggactat caaggtgtgg cagttgggct cttcgtcacc    660

aaacttcact ttggaaggac atgagaaagg cgtgaattgc attgattact acagtggtgg    720

ggacaagcca tacctcattt caggtgcaga tgaccgtctt gttaaaatat gggattatca    780

gaataaaaca tgtgtgcaga cactggaagg acatgcccaa aatgtgtctt gtgccagctt    840

tcatcctgag ttgccaatca ttatcacagg ttcagaagat ggaacagtac gtatttggca    900

ttcaagcacc taccggcttg agagcacact gaattatgga atggagaggg tatggtgcgt    960

ggccagtcta agagggtcaa acaatgtcgc tttgggctat gatgaaggga gcatcattgt   1020

taagcttggt cgggaggaac ctgccatgtc catggatgcc aatggaaaga taatttgggc   1080

caagcattca gaagtccagc aggccaacct aaaagcaatg ggagatgctg aaattaaaga   1140

tggtgaaaga ttgccactgg cagtaaagga tatgggcagt tgtgaaatat accctcagac   1200

tattcagcac aatcctaatg ggcggtttgt ggtggtgtgt ggtgatgggg agtatatcat   1260

ctacacagca atggcattga gaaacaagag ctttggatct gctcaggagt ttgcatgggc   1320

ccacgattct tcagagtatg caataagaga gagcaacagc attgtaaaga tatttaagaa   1380

ctttaaggaa aaaaaatcat ttaaaccaga ttttggagca gaaagtatct acggcggctt   1440

cttattggga gtcagatctg taaatggctt agccttctat gactgggaca atacagaact   1500

catacgaaga attgaaattc agcccaaaca tattttctgg tctgactctg gagagctagt   1560

ctgtattgct actgaggaat cattttttat ccttaagtat ctgtcagaaa aagtcttggc   1620

tgcacaggaa acacatgagg gagttactga agatggcatt gaagatgcct ttgaggttct   1680

tggtgagatt caggaaattg tgaaaacagg gctttgggta ggcgattgct tcatttacac   1740

aagttctgtg aacagattaa attattatgt tggaggagaa atagtcacca ttgcccactt   1800

ggacaggacg atgtatctcc taggctacat tcctaaagac aacaggcttt atctggggga   1860

taaagaattg aacatcatta gctattccct gctggtttca gtcctggaat accagacagc   1920

tgtcatgcgg agggacttta gcatggctga taaggtcctt cctaccattc caaaagaaca   1980

gaggaccaga gttgcacact ttttggaaaa gcagggcttc aagcagcaag ctcttacagt   2040

atccacagat cctgagcatc gttttgagct tgctcttcag cttggagagt taaaaattgc   2100

ataccagtta gcagtggaag cagagtcaga acagaagtgg aaacaacttg ctgaacttgc   2160

cattagtaaa tgtcagtttg gcctagccca ggagtgcctg catcatgcac aggattatgg   2220

gggcctgctg cttttggcca ctgcctctgg aaatgctaat atggtgaaca agctagcaga   2280

gggtgcggag agagatggca aaaataatgt ggcattcatg agctactttt tacagggcaa   2340

ggttgatgcc tgcctagagc tcttaattag aactggacgg ctgccagaag ctgccttctt   2400

ggcccgaact tacttaccca gtcaggtttc aagggtagtg aaactctgga gagagaatct   2460

ctcaaaagtc aatcagaaag cagcagaatc ccttgctgac ccaacagagt atgaaaacct   2520

gttccctgga ttaaaagaag cctttgttgt tgaagaatgg gtgaaggaaa cacatgctga   2580

tctgtggcca gccaaacaat acccacttgt cacgccaaat gaagagagaa atgtcatgga   2640

agagggaaaa gactttcagc cctcaagatc tacagctcaa caggaacttg atgggaaacc   2700

tgcttctcct actccggtta ttgtggcctc ccacacagcc aacaaagaag aaaagagttt   2760

actcgaacta gaagtagatt tggataattt ggaattagaa gatattgaca caacagatat   2820

caatctggat gaagatattt tggatgattg actgtaatgc tttccattta cctgactaaa   2880

cagatcatta ttatatatag gtattgattg ctaccctgac cacagtgctt tggactatga   2940

gaaacttctt agatttttat atgtaaatgc tgtggaccac tgggagcaca atgcccacat   3000

catcttaaga agagtttatg tgcagcattt aaatcactgt gttttccttg ttaactaaaa   3060

cagacatggg ctttgatttt tttcatacta ttagaccata tctcataaaa ccttttgaat   3120

taatgaaggt acttgtttcc tttctcaata atgaaaatag gcttctagtt ttagaaggct   3180

gagccgaaac tacaccttgc ctagggatca gccccactgt cttttctttg tataactaaa   3240

tctgcatttt caaatgttgt caatcacatt tttcttagag ctgaatatcc aggctgtaat   3300

tctctaaacc ctttttcttg acctcattgc atcattccac aggtcttgcc ccgattttgt   3360

ctagcagcta cccatttctg gagtcaggat gtgaaacctc tgttcctctg acctcattaa   3420

gctgggggtc tgtctaagtt aacgtttgcc ctatttggta acacaaaaac acaccagact   3480

ttttaaccgt acgctcatct aacatgattt gagaaattca taaccaggca ctcaaatatc   3540

cttgtagcct acgaaaagtg agtagggtaa taatttttgc tttgtaggga gaactacaaa   3600

ttgatatctt ttaatctggc cattttttaa catttagctc aatattaaca gagaaatgta   3660

gtcagtattt agtaaaataa atgtattttt aaaatatttt taggaagctg cagaatggcg   3720

actgagtgct tcttgataag tctgcagtgt tagttctata taggctccct tctgtgcttc   3780

tgtttttgca aagacctgtt taaattaaaa agaaaatttt aaaacaatag gacatatgct   3840

atttataaag tttttcagtt ttaagacatc attagcattt ctgtagtagc aaagagtcct   3900

acttaaaaag ggctttcaga tttcacaatt tttcccccga ttatacaata attaataaac   3960

acacatggac agaaaaacaa tacccaacac atttcaagca atactaattc taaacaccag   4020

aagtatccaa ttaagaccct gacattgtat taatattaat acttccttcg agatcaaaac   4080

aaaaaccatt aggttagaga gaaatctgga ggctaagagt taccaaacta acttttgact   4140

ttaaagaata ttttctccaa aaacattgcg ctttatcagg ttcataaaga aaatcagtac   4200

tgtagtttct ctctactctt cctaggatgt catcacaggt cattgtttcc ttagctttgc   4260

agcatgcaaa cagtattact aggatagaag ccagttccac aaaaccatgt atattctgag   4320

cattagaaga gatgaaatta attatacaat ctcctcccct tcccttcctg aaaatatcat   4380

ctcaactctc agcacttaca gataaatgta cataagccca tggttttgag aggtatgcag   4440

ctccaaaatg acaatacagc taaggcttga tgatatacaa gcatcacact ctccacttct   4500

tgacacatgc ccatttcccc cgatgtgatg tgaccacaca aagacaggaa gctgctctgg   4560

gggacatgtg ctacttagtc ctctaccctg tcctgttggt ggcttgaaca cctcagatgc   4620

agctcagccc ttccagtgct ccaaagaaca aaggggctgc tccctgcact gtcagaactt   4680

ctctggactc cagctgctag caccacatca ctcaacctac tttactgcac tttacccccc   4740

tcccctgtct gtttctattg tccaggctga agaaatatgg ggacaaatca tactgatgtt   4800

ttcaagacca cagatgtccc atattcacaa atctgtttag ttaccattaa ttatgaccca   4860

attctgaatt tttcccagct caattaccac cacaaaacaa ccaatatgaa aaaaaaactt   4920

taccttgatt aaatttattc cctcagcagc ctgatccttg gccccttgag ccgactggcc   4980

atctggatgg agcacgtgat acagctggac caagttggtt gcatcatcga ttctgagaat   5040

gaaagggttt aatgttatct aggggttttc ttcatttgat tcacagtcct ataaaagtgt   5100

gtgccaactt caaactaaat tacatttcag actttcctca ggctggaggg attggggaag   5160

gaccttcagt tttacagttt caaaagcatt ttcaggaaaa ttgactaatt taggcctcac   5220

accaactccg tgaggcagct agggcaggag tcactgcagg aagtgtccaa tttatgaaag   5280

tgaatatatt ccaaatgtgg ctatattctt tttggaaaaa gagcaccatt tctcacagaa   5340

acagcattcc taatggtaga caatttccag gccagcttac ttcaccagca tgtaatagtc   5400

taatccaact cagaggacag aaacacagct tcatcccaca taagcaggag ggtggtggtc   5460

acagggatct caaagtcact tgcctctaag tgacatttgc taacagacaa atgcctctac   5520

aagaggcccc ctaagattcc aaggaaagga ttcacaggaa cgcattagta aaatagcatc   5580

ctagtgaagc aaatttgaaa ttatacacac acatcagaca aaaaggaaaa tcgggttcta   5640

catcagcaat ctgtcttaac ttcagcatca cacaactacc tatgaagaag acagaacaag   5700

aattcagttc ttctggtctg tacttctcag aaatgtataa acaattttta tcaacattaa   5760

aactgtccta gcaaaaccaa acaatcacta tcttttcaca cagctgacac tttcccacca   5820

tttgccatct catcgctgga gggcacagaa aaacgacact caaaatgctt gtgcttttga   5880

ggctctgcta tatacactaa gtgaactact ggcttccagt tgggaatgga gggctgagga   5940

caccctaatt cagtgcttcc gcagctagca ctcttcagcc ttccctgcgt tccccttacc   6000

tgagctgggg gatgaagagc agggtgacag tgggagtaag tacagaattc ctcaagcctt   6060

ggtagcctta gagaaatgct ctgggcttat actgaggctc atctacccta aaggccatct   6120

ctcaggaaaa cagagctgtt gtatcataaa gcttttcagg gggaaaaaaa taaaaaatgt   6180

tcatcacaaa tctattgtgc ttgttataat ctaacaaagt ccactaaatg tagtaacgaa   6240

atgtctcccc aataaaaaat taagattccc tttggagctt aggcatgtgg ccttataaag   6300

agcttaactg gactgctacc tgttggtatg ttcagggctt cattaggttc atgcttaagt   6360

ataatgcctg tgcctcacag aacaatttaa atttagctta acaccccacc catacttaaa   6420

gagcaaataa attatatttc gaaaagattt taaaataatc tcaatataaa aaccaacagt   6480

gggaactgag tctggaataa atgtgtgcag aatcctaatt cttttctgag ctccactcag   6540

tgaggatatg caccctctac tgtccagcct gtggtttgca gtaagctcac tcttctgttc   6600

agaatgacca caggagggcc tttacctagg aatagcagga aaagctaagt aagtactcaa   6660

acttccctcc cagtaagcat gaattgcttc agatgtaaag cttacatgtg atgagtaata   6720

ctataatatc atacattaat atatcctaat aaactttaat tttcaaac                6768


<210>  1809
<211>  906
<212>  PRT
<213>  Homo sapiens

<400>  1809


Met Pro Leu Arg Leu Asp Ile Lys Arg Lys Leu Thr Ala Arg Ser Asp 
1               5                   10                  15      


Arg Val Lys Ser Val Asp Leu His Pro Thr Glu Pro Trp Met Leu Ala 
            20                  25                  30          


Ser Leu Tyr Asn Gly Ser Val Cys Val Trp Asn His Glu Thr Gln Thr 
        35                  40                  45              


Leu Val Lys Thr Phe Glu Val Cys Asp Leu Pro Val Arg Ala Ala Lys 
    50                  55                  60                  


Phe Val Ala Arg Lys Asn Trp Val Val Thr Gly Ala Asp Asp Met Gln 
65                  70                  75                  80  


Ile Arg Val Phe Asn Tyr Asn Thr Leu Glu Arg Val His Met Phe Glu 
                85                  90                  95      


Ala His Ser Asp Tyr Ile Arg Cys Ile Ala Val His Pro Thr Gln Pro 
            100                 105                 110         


Phe Ile Leu Thr Ser Ser Asp Asp Met Leu Ile Lys Leu Trp Asp Trp 
        115                 120                 125             


Asp Lys Lys Trp Ser Cys Ser Gln Val Phe Glu Gly His Thr His Tyr 
    130                 135                 140                 


Val Met Gln Ile Val Ile Asn Pro Lys Asp Asn Asn Gln Phe Ala Ser 
145                 150                 155                 160 


Ala Ser Leu Asp Arg Thr Ile Lys Val Trp Gln Leu Gly Ser Ser Ser 
                165                 170                 175     


Pro Asn Phe Thr Leu Glu Gly His Glu Lys Gly Val Asn Cys Ile Asp 
            180                 185                 190         


Tyr Tyr Ser Gly Gly Asp Lys Pro Tyr Leu Ile Ser Gly Ala Asp Asp 
        195                 200                 205             


Arg Leu Val Lys Ile Trp Asp Tyr Gln Asn Lys Thr Cys Val Gln Thr 
    210                 215                 220                 


Leu Glu Gly His Ala Gln Asn Val Ser Cys Ala Ser Phe His Pro Glu 
225                 230                 235                 240 


Leu Pro Ile Ile Ile Thr Gly Ser Glu Asp Gly Thr Val Arg Ile Trp 
                245                 250                 255     


His Ser Ser Thr Tyr Arg Leu Glu Ser Thr Leu Asn Tyr Gly Met Glu 
            260                 265                 270         


Arg Val Trp Cys Val Ala Ser Leu Arg Gly Ser Asn Asn Val Ala Leu 
        275                 280                 285             


Gly Tyr Asp Glu Gly Ser Ile Ile Val Lys Leu Gly Arg Glu Glu Pro 
    290                 295                 300                 


Ala Met Ser Met Asp Ala Asn Gly Lys Ile Ile Trp Ala Lys His Ser 
305                 310                 315                 320 


Glu Val Gln Gln Ala Asn Leu Lys Ala Met Gly Asp Ala Glu Ile Lys 
                325                 330                 335     


Asp Gly Glu Arg Leu Pro Leu Ala Val Lys Asp Met Gly Ser Cys Glu 
            340                 345                 350         


Ile Tyr Pro Gln Thr Ile Gln His Asn Pro Asn Gly Arg Phe Val Val 
        355                 360                 365             


Val Cys Gly Asp Gly Glu Tyr Ile Ile Tyr Thr Ala Met Ala Leu Arg 
    370                 375                 380                 


Asn Lys Ser Phe Gly Ser Ala Gln Glu Phe Ala Trp Ala His Asp Ser 
385                 390                 395                 400 


Ser Glu Tyr Ala Ile Arg Glu Ser Asn Ser Ile Val Lys Ile Phe Lys 
                405                 410                 415     


Asn Phe Lys Glu Lys Lys Ser Phe Lys Pro Asp Phe Gly Ala Glu Ser 
            420                 425                 430         


Ile Tyr Gly Gly Phe Leu Leu Gly Val Arg Ser Val Asn Gly Leu Ala 
        435                 440                 445             


Phe Tyr Asp Trp Asp Asn Thr Glu Leu Ile Arg Arg Ile Glu Ile Gln 
    450                 455                 460                 


Pro Lys His Ile Phe Trp Ser Asp Ser Gly Glu Leu Val Cys Ile Ala 
465                 470                 475                 480 


Thr Glu Glu Ser Phe Phe Ile Leu Lys Tyr Leu Ser Glu Lys Val Leu 
                485                 490                 495     


Ala Ala Gln Glu Thr His Glu Gly Val Thr Glu Asp Gly Ile Glu Asp 
            500                 505                 510         


Ala Phe Glu Val Leu Gly Glu Ile Gln Glu Ile Val Lys Thr Gly Leu 
        515                 520                 525             


Trp Val Gly Asp Cys Phe Ile Tyr Thr Ser Ser Val Asn Arg Leu Asn 
    530                 535                 540                 


Tyr Tyr Val Gly Gly Glu Ile Val Thr Ile Ala His Leu Asp Arg Thr 
545                 550                 555                 560 


Met Tyr Leu Leu Gly Tyr Ile Pro Lys Asp Asn Arg Leu Tyr Leu Gly 
                565                 570                 575     


Asp Lys Glu Leu Asn Ile Ile Ser Tyr Ser Leu Leu Val Ser Val Leu 
            580                 585                 590         


Glu Tyr Gln Thr Ala Val Met Arg Arg Asp Phe Ser Met Ala Asp Lys 
        595                 600                 605             


Val Leu Pro Thr Ile Pro Lys Glu Gln Arg Thr Arg Val Ala His Phe 
    610                 615                 620                 


Leu Glu Lys Gln Gly Phe Lys Gln Gln Ala Leu Thr Val Ser Thr Asp 
625                 630                 635                 640 


Pro Glu His Arg Phe Glu Leu Ala Leu Gln Leu Gly Glu Leu Lys Ile 
                645                 650                 655     


Ala Tyr Gln Leu Ala Val Glu Ala Glu Ser Glu Gln Lys Trp Lys Gln 
            660                 665                 670         


Leu Ala Glu Leu Ala Ile Ser Lys Cys Gln Phe Gly Leu Ala Gln Glu 
        675                 680                 685             


Cys Leu His His Ala Gln Asp Tyr Gly Gly Leu Leu Leu Leu Ala Thr 
    690                 695                 700                 


Ala Ser Gly Asn Ala Asn Met Val Asn Lys Leu Ala Glu Gly Ala Glu 
705                 710                 715                 720 


Arg Asp Gly Lys Asn Asn Val Ala Phe Met Ser Tyr Phe Leu Gln Gly 
                725                 730                 735     


Lys Val Asp Ala Cys Leu Glu Leu Leu Ile Arg Thr Gly Arg Leu Pro 
            740                 745                 750         


Glu Ala Ala Phe Leu Ala Arg Thr Tyr Leu Pro Ser Gln Val Ser Arg 
        755                 760                 765             


Val Val Lys Leu Trp Arg Glu Asn Leu Ser Lys Val Asn Gln Lys Ala 
    770                 775                 780                 


Ala Glu Ser Leu Ala Asp Pro Thr Glu Tyr Glu Asn Leu Phe Pro Gly 
785                 790                 795                 800 


Leu Lys Glu Ala Phe Val Val Glu Glu Trp Val Lys Glu Thr His Ala 
                805                 810                 815     


Asp Leu Trp Pro Ala Lys Gln Tyr Pro Leu Val Thr Pro Asn Glu Glu 
            820                 825                 830         


Arg Asn Val Met Glu Glu Gly Lys Asp Phe Gln Pro Ser Arg Ser Thr 
        835                 840                 845             


Ala Gln Gln Glu Leu Asp Gly Lys Pro Ala Ser Pro Thr Pro Val Ile 
    850                 855                 860                 


Val Ala Ser His Thr Ala Asn Lys Glu Glu Lys Ser Leu Leu Glu Leu 
865                 870                 875                 880 


Glu Val Asp Leu Asp Asn Leu Glu Leu Glu Asp Ile Asp Thr Thr Asp 
                885                 890                 895     


Ile Asn Leu Asp Glu Asp Ile Leu Asp Asp 
            900                 905     

<210>  1810
<211>  516
<212>  DNA
<213>  Homo sapiens

<400>  1810
gatggcaaat ggtgggaaag tgtcagctgt gtgaaaagat actggcctgg aaattgtcta     60

ccattaggaa tgctgtttct gtgagaaatg gtgctctttt tccaaaaaga atatagccac    120

atttggaata tattcacttt cataaattgg acacttcctg cagtgactcc tgccctagct    180

gcctcacgga gttggtgtga ggcctaaatt agtcaatttt cctgaaaatg cttttgaaac    240

tgtaaaactg aaggtccttc cccaatccct ccagcctgag gaaagtctga aatgtaattt    300

agtttgaagt tggcacacac ttttatagga ctgtgaatca aatgaagaaa acccctagat    360

aacattaaac cctttcattc tcagaatcga tgatgcaacc aacttggtcc agctgtatca    420

cgtgctccat ccagatggcc agtcggctca aggggccaag gatcaggctg ctgagggaat    480

aaatttaatc aaggtaaagt ttttttttca tattgg                              516


<210>  1811
<211>  35
<212>  PRT
<213>  Homo sapiens

<400>  1811


Met Val Gly Lys Cys Gln Leu Cys Glu Lys Ile Leu Ala Trp Lys Leu 
1               5                   10                  15      


Ser Thr Ile Arg Asn Ala Val Ser Val Arg Asn Gly Ala Leu Phe Pro 
            20                  25                  30          


Lys Arg Ile 
        35  

<210>  1812
<211>  908
<212>  DNA
<213>  Homo sapiens

<400>  1812
agagcacttc atgtgataaa tttggctgag atggttcact tttttttttt ttcttttgag     60

acagagtttc gctccattgc cctggctgga gtgcagtggc gcgatctagg ctcactgcaa    120

gctctgtctc ccgggttcac gccattctcc tgcctcagcc tcccgagtag ctggggtaat    180

tacaggcgcc catcaccggt ccggctaatt tttttgtatt tttattagag acagggtttc    240

actgcattag ccaggatggt ctcgatctcc tgacctcatg atccacctgc ttcggcctcc    300

caaagtgctg ggattacagg cgtgagccac tgtgcctggc tgagatggtt cacttttaaa    360

catcatctcc cacttcctaa ttctgatcat ccttttcttg ggggaaaact ttaaattccc    420

gagtaaattc ccttgtcttc atatatatct tcacttgtgg tttcaggaac ttgatgggaa    480

acctgcttct cctactccgg ttattgtggc ctcccacaca gccaacaaag aagaaaagag    540

tttactcgaa ctagaagtag atttggataa tttggaatta gaagatattg acacaacaga    600

tatcaatctg gatgaagata ttttggatga ttgactgtaa tgctttccat ttacctgact    660

aaacagatca ttattatata taggtattga ttgctaccct gaccacagtg ctttggacta    720

tgagaaactt cttagatttt tatatgtaaa tgctgtggac cactgggagc acaatgccca    780

catcatctta agaagagttt atgtgcagca tttaaatcac tgtgttttcc ttgttaacta    840

aaacagacat gggctttgat ttttttcata ctattagacc atatctcata aaaccttttg    900

aattaatg                                                             908


<210>  1813
<211>  65
<212>  PRT
<213>  Homo sapiens

<400>  1813


Met Val His Phe Phe Phe Phe Ser Phe Glu Thr Glu Phe Arg Ser Ile 
1               5                   10                  15      


Ala Leu Ala Gly Val Gln Trp Arg Asp Leu Gly Ser Leu Gln Ala Leu 
            20                  25                  30          


Ser Pro Gly Phe Thr Pro Phe Ser Cys Leu Ser Leu Pro Ser Ser Trp 
        35                  40                  45              


Gly Asn Tyr Arg Arg Pro Ser Pro Val Arg Leu Ile Phe Leu Tyr Phe 
    50                  55                  60                  


Tyr 
65  

<210>  1814
<211>  511
<212>  DNA
<213>  Homo sapiens

<400>  1814
aattaagagc tgataaatgt catggaagag ggaaaagact ttcagccctc aagatctaca     60

gctcaacagg aacttgatgg gaaacctgct tctcctactc cggttattgt ggcctcccac    120

acagccaaca aagaagaaaa gagtttactc gaactagaag tagatttgga taatttggaa    180

ttagaagata ttgacacaac agatatcaat ctggatgaag atattttgga tgattgactg    240

taatgctttc catttacctg actaaacaga tcattattat atataggtat tgattgctac    300

cctgaccaca gtgctttgga ctatgagaaa cttcttagat ttttatatgt aaatgctgtg    360

gaccactggg agcacaatgc ccacatcatc ttaagaagag tttatgtgca gcatttaaat    420

cactgtgttt tccttgttaa ctaaaacaga catgggcttt gatttttttc atactattag    480

accatatctc ataaaacctt ttgaattaat g                                   511


<210>  1815
<211>  71
<212>  PRT
<213>  Homo sapiens

<400>  1815


Met Glu Glu Gly Lys Asp Phe Gln Pro Ser Arg Ser Thr Ala Gln Gln 
1               5                   10                  15      


Glu Leu Asp Gly Lys Pro Ala Ser Pro Thr Pro Val Ile Val Ala Ser 
            20                  25                  30          


His Thr Ala Asn Lys Glu Glu Lys Ser Leu Leu Glu Leu Glu Val Asp 
        35                  40                  45              


Leu Asp Asn Leu Glu Leu Glu Asp Ile Asp Thr Thr Asp Ile Asn Leu 
    50                  55                  60                  


Asp Glu Asp Ile Leu Asp Asp 
65                  70      

<210>  1816
<211>  3125
<212>  DNA
<213>  Homo sapiens

<400>  1816
gactatcgcg agaatcggct cccggaagtt ccacgtcagt cagtctgacg gtcagtggat     60

cggtgggttt atctcaaggc ctgagtagcc ggtaacaaac gagggttccc gggattggac    120

cgacgcagcc atgcctctgc gacttgatat caaaagaaag ctaactgcta gatctgatcg    180

agttaagagt gtggatctgc atcctacaga gccatggatg ttggcaagtc tttacaatgg    240

cagtgtgtgt gtttggaatc atgaaacaca gacactggtg aagacatttg aagtatgtga    300

tcttcctgtt cgagctgcaa agtttgttgc aaggaagaat tgggttgtga caggagcgga    360

tgacatgcag attagagtgt tcaattacaa tactctggag agagttcata tgtttgaagc    420

acactcagac tacattcgct gtattgctgt tcatccaacc cagcctttca ttctaactag    480

cagtgatgac atgcttatta agctctggga ctgggataaa aaatggtctt gctcacaagt    540

gtttgaagga cacacccatt atgttatgca gattgtgatc aaccccaaag ataacaatca    600

gtttgccagt gcctctttgg acaggactat caaggtgtgg cagttgggct cttcgtcacc    660

aaacttcact ttggaaggac atgagaaagg cgtgaattgc attgattact acagtggtgg    720

ggacaagcca tacctcattt caggtgcaga tgaccgtctt gttaaaatat gggattatca    780

gaataaaaca tgtgtgcaga cactggaagg acatgcccaa aatgtgtctt gtgccagctt    840

tcatcctgag ttgccaatca ttatcacagg ttcagaagat ggaacagtac gtatttggca    900

ttcaagcacc taccggcttg agagcacact gaattatgga atggagaggg tatggtgcgt    960

ggccagtcta agagggtcaa acaatgtcgc tttgggctat gatgaaggga gcatcattgt   1020

taagcttggt cgggaggaac ctgccatgtc catggatgcc aatggaaaga taatttgggc   1080

caagcattca gaagtccagc aggccaacct aaaagcaatg ggagatgctg aaattaaaga   1140

tggtgaaaga ttgccactgg cagtaaagga tatgggcagt tgtgaaatat accctcagac   1200

tattcagcac aatcctaatg ggcggtttgt ggtggtgtgt ggtgatgggg agtatatcat   1260

ctacacagca atggcattga gaaacaagag ctttggatct gctcaggagt ttgcatgggc   1320

ccacgattct tcagagtatg caataagaga gagcaacagc attgtaaaga tatttaagaa   1380

ctttaaggaa aaaaaatcat ttaaaccaga ttttggagca gaaagtatct acggcggctt   1440

cttattggga gtcagatctg taaatggctt agccttctat gactgggaca atacagaact   1500

catacgaaga attgaaattc agcccaaaca tattttctgg tctgactctg gagagctagt   1560

ctgtattgct actgaggaat cattttttat ccttaagtat ctgtcagaaa aagtcttggc   1620

tgcacaggaa acacatgagg gagttactga agatggcatt gaagatgcct ttgaggttct   1680

tggtgagatt caggaaattg tgaaaacagg gctttgggta ggcgattgct tcatttacac   1740

aagttctgtg aacagattaa attattatgt tggaggagaa atagtcacca ttgcccactt   1800

ggacaggacg atgtatctcc taggctacat tcctaaagac aacaggcttt atctggggga   1860

taaagaattg aacatcatta gctattccct gctggtttca gtcctggaat accagacagc   1920

tgtcatgcgg agggacttta gcatggctga taaggtcctt cctaccattc caaaagaaca   1980

gaggaccaga gttgcacact ttttggaaaa gcagggcttc aagcagcaag ctcttacagt   2040

atccacagat cctgagcatc gttttgagct tgctcttcag cttggagagt taaaaattgc   2100

ataccagtta gcagtggaag cagagtcaga acagaagtgg aaacaacttg ctgaacttgc   2160

cattagtaaa tgtcagtttg gcctagccca ggagtgcctg catcatgcac aggattatgg   2220

gggcctgctg cttttggcca ctgcctctgg aaatgctaat atggtgaaca agctagcaga   2280

gggtgcggag agagatggca aaaataatgt ggcattcatg agctactttt tacagggcaa   2340

ggttgatgcc tgcctagagc tcttaattag aactggacgg ctgccagaag ctgccttctt   2400

ggcccgaact tacttaccca gtcaggtttc aagggtagtg aaactctgga gagagaatct   2460

ctcaaaagtc aatcagaaag cagcagaatc ccttgctgac ccaacagagt atgaaaacct   2520

gttccctgga ttaaaagaag cctttgttgt tgaagaatgg gtgaaggaaa cacatgctga   2580

tctgtggcca gccaaacaat acccacttgt cacgccaaat gaagagagaa atgtcatgga   2640

agagggaaaa gactttcagc cctcaagatc tacagctcaa caggaacttg atgggaaacc   2700

tgcttctcct actccggtta ttgtggcctc ccacacagcc aacaaagaag aaaagagttt   2760

actcgaacta gaagtagatt tggataattt ggaattagaa gatattgaca caacagatat   2820

caatctggat gaagatattt tggatgattg actgtaatgc tttccattta cctgactaaa   2880

cagatcatta ttatatatag gtattgattg ctaccctgac cacagtgctt tggactatga   2940

gaaacttctt agatttttat atgtaaatgc tgtggaccac tgggagcaca atgcccacat   3000

catcttaaga agagtttatg tgcagcattt aaatcactgt gttttccttg ttaactaaaa   3060

cagacatggg ctttgatttt tttcatacta ttagaccata tctcataaaa ccttttgaat   3120

taatg                                                               3125


<210>  1817
<211>  906
<212>  PRT
<213>  Homo sapiens

<400>  1817


Met Pro Leu Arg Leu Asp Ile Lys Arg Lys Leu Thr Ala Arg Ser Asp 
1               5                   10                  15      


Arg Val Lys Ser Val Asp Leu His Pro Thr Glu Pro Trp Met Leu Ala 
            20                  25                  30          


Ser Leu Tyr Asn Gly Ser Val Cys Val Trp Asn His Glu Thr Gln Thr 
        35                  40                  45              


Leu Val Lys Thr Phe Glu Val Cys Asp Leu Pro Val Arg Ala Ala Lys 
    50                  55                  60                  


Phe Val Ala Arg Lys Asn Trp Val Val Thr Gly Ala Asp Asp Met Gln 
65                  70                  75                  80  


Ile Arg Val Phe Asn Tyr Asn Thr Leu Glu Arg Val His Met Phe Glu 
                85                  90                  95      


Ala His Ser Asp Tyr Ile Arg Cys Ile Ala Val His Pro Thr Gln Pro 
            100                 105                 110         


Phe Ile Leu Thr Ser Ser Asp Asp Met Leu Ile Lys Leu Trp Asp Trp 
        115                 120                 125             


Asp Lys Lys Trp Ser Cys Ser Gln Val Phe Glu Gly His Thr His Tyr 
    130                 135                 140                 


Val Met Gln Ile Val Ile Asn Pro Lys Asp Asn Asn Gln Phe Ala Ser 
145                 150                 155                 160 


Ala Ser Leu Asp Arg Thr Ile Lys Val Trp Gln Leu Gly Ser Ser Ser 
                165                 170                 175     


Pro Asn Phe Thr Leu Glu Gly His Glu Lys Gly Val Asn Cys Ile Asp 
            180                 185                 190         


Tyr Tyr Ser Gly Gly Asp Lys Pro Tyr Leu Ile Ser Gly Ala Asp Asp 
        195                 200                 205             


Arg Leu Val Lys Ile Trp Asp Tyr Gln Asn Lys Thr Cys Val Gln Thr 
    210                 215                 220                 


Leu Glu Gly His Ala Gln Asn Val Ser Cys Ala Ser Phe His Pro Glu 
225                 230                 235                 240 


Leu Pro Ile Ile Ile Thr Gly Ser Glu Asp Gly Thr Val Arg Ile Trp 
                245                 250                 255     


His Ser Ser Thr Tyr Arg Leu Glu Ser Thr Leu Asn Tyr Gly Met Glu 
            260                 265                 270         


Arg Val Trp Cys Val Ala Ser Leu Arg Gly Ser Asn Asn Val Ala Leu 
        275                 280                 285             


Gly Tyr Asp Glu Gly Ser Ile Ile Val Lys Leu Gly Arg Glu Glu Pro 
    290                 295                 300                 


Ala Met Ser Met Asp Ala Asn Gly Lys Ile Ile Trp Ala Lys His Ser 
305                 310                 315                 320 


Glu Val Gln Gln Ala Asn Leu Lys Ala Met Gly Asp Ala Glu Ile Lys 
                325                 330                 335     


Asp Gly Glu Arg Leu Pro Leu Ala Val Lys Asp Met Gly Ser Cys Glu 
            340                 345                 350         


Ile Tyr Pro Gln Thr Ile Gln His Asn Pro Asn Gly Arg Phe Val Val 
        355                 360                 365             


Val Cys Gly Asp Gly Glu Tyr Ile Ile Tyr Thr Ala Met Ala Leu Arg 
    370                 375                 380                 


Asn Lys Ser Phe Gly Ser Ala Gln Glu Phe Ala Trp Ala His Asp Ser 
385                 390                 395                 400 


Ser Glu Tyr Ala Ile Arg Glu Ser Asn Ser Ile Val Lys Ile Phe Lys 
                405                 410                 415     


Asn Phe Lys Glu Lys Lys Ser Phe Lys Pro Asp Phe Gly Ala Glu Ser 
            420                 425                 430         


Ile Tyr Gly Gly Phe Leu Leu Gly Val Arg Ser Val Asn Gly Leu Ala 
        435                 440                 445             


Phe Tyr Asp Trp Asp Asn Thr Glu Leu Ile Arg Arg Ile Glu Ile Gln 
    450                 455                 460                 


Pro Lys His Ile Phe Trp Ser Asp Ser Gly Glu Leu Val Cys Ile Ala 
465                 470                 475                 480 


Thr Glu Glu Ser Phe Phe Ile Leu Lys Tyr Leu Ser Glu Lys Val Leu 
                485                 490                 495     


Ala Ala Gln Glu Thr His Glu Gly Val Thr Glu Asp Gly Ile Glu Asp 
            500                 505                 510         


Ala Phe Glu Val Leu Gly Glu Ile Gln Glu Ile Val Lys Thr Gly Leu 
        515                 520                 525             


Trp Val Gly Asp Cys Phe Ile Tyr Thr Ser Ser Val Asn Arg Leu Asn 
    530                 535                 540                 


Tyr Tyr Val Gly Gly Glu Ile Val Thr Ile Ala His Leu Asp Arg Thr 
545                 550                 555                 560 


Met Tyr Leu Leu Gly Tyr Ile Pro Lys Asp Asn Arg Leu Tyr Leu Gly 
                565                 570                 575     


Asp Lys Glu Leu Asn Ile Ile Ser Tyr Ser Leu Leu Val Ser Val Leu 
            580                 585                 590         


Glu Tyr Gln Thr Ala Val Met Arg Arg Asp Phe Ser Met Ala Asp Lys 
        595                 600                 605             


Val Leu Pro Thr Ile Pro Lys Glu Gln Arg Thr Arg Val Ala His Phe 
    610                 615                 620                 


Leu Glu Lys Gln Gly Phe Lys Gln Gln Ala Leu Thr Val Ser Thr Asp 
625                 630                 635                 640 


Pro Glu His Arg Phe Glu Leu Ala Leu Gln Leu Gly Glu Leu Lys Ile 
                645                 650                 655     


Ala Tyr Gln Leu Ala Val Glu Ala Glu Ser Glu Gln Lys Trp Lys Gln 
            660                 665                 670         


Leu Ala Glu Leu Ala Ile Ser Lys Cys Gln Phe Gly Leu Ala Gln Glu 
        675                 680                 685             


Cys Leu His His Ala Gln Asp Tyr Gly Gly Leu Leu Leu Leu Ala Thr 
    690                 695                 700                 


Ala Ser Gly Asn Ala Asn Met Val Asn Lys Leu Ala Glu Gly Ala Glu 
705                 710                 715                 720 


Arg Asp Gly Lys Asn Asn Val Ala Phe Met Ser Tyr Phe Leu Gln Gly 
                725                 730                 735     


Lys Val Asp Ala Cys Leu Glu Leu Leu Ile Arg Thr Gly Arg Leu Pro 
            740                 745                 750         


Glu Ala Ala Phe Leu Ala Arg Thr Tyr Leu Pro Ser Gln Val Ser Arg 
        755                 760                 765             


Val Val Lys Leu Trp Arg Glu Asn Leu Ser Lys Val Asn Gln Lys Ala 
    770                 775                 780                 


Ala Glu Ser Leu Ala Asp Pro Thr Glu Tyr Glu Asn Leu Phe Pro Gly 
785                 790                 795                 800 


Leu Lys Glu Ala Phe Val Val Glu Glu Trp Val Lys Glu Thr His Ala 
                805                 810                 815     


Asp Leu Trp Pro Ala Lys Gln Tyr Pro Leu Val Thr Pro Asn Glu Glu 
            820                 825                 830         


Arg Asn Val Met Glu Glu Gly Lys Asp Phe Gln Pro Ser Arg Ser Thr 
        835                 840                 845             


Ala Gln Gln Glu Leu Asp Gly Lys Pro Ala Ser Pro Thr Pro Val Ile 
    850                 855                 860                 


Val Ala Ser His Thr Ala Asn Lys Glu Glu Lys Ser Leu Leu Glu Leu 
865                 870                 875                 880 


Glu Val Asp Leu Asp Asn Leu Glu Leu Glu Asp Ile Asp Thr Thr Asp 
                885                 890                 895     


Ile Asn Leu Asp Glu Asp Ile Leu Asp Asp 
            900                 905     

<210>  1818
<211>  3508
<212>  DNA
<213>  Homo sapiens

<400>  1818
gtcagtcagt ctgacggtca gtggatcggt gggtttatct caaggcctga gtagccggta     60

acaaacgagg gttcccggga ttggaccgac gcagccatgc ctctgcgact tgatatcaaa    120

agaaagctaa ctgctagatc tgatcgagtt aagagtgtgg atctgcatcc tacagagcca    180

tggatgttgg caagtcttta caatggcagt gtgtgtgttt ggaatcatga aacacaggta    240

ggaatttttc aggactgtat tagaaataaa atactatgtg agactgtgtt tataatgaaa    300

gagaagaaat attataacag aatccagaat ctatatgcaa actgctttct caagttggta    360

caaagtattt taaatatgaa ggaactaaca tttatgaggg gatagtttgt aggagaaact    420

gtcctgggta tgttatatac aatatttaaa tataacaact ctgacttagg tagtattagc    480

tcttttttga aattgagaaa actgatggta ttatagaatc acttgctaaa gtatttaatc    540

gttagttttc cattcagtga atactctatc ttaagaatga tatcgttaaa tttatttttc    600

tcccagatgc ccaatataat gatacacaga taaatctttc actcagccat atagattata    660

tcagggaaat atttatagtc agcttttgat tatacacaca tcttacagat tgtctgcctg    720

aatgcttgac tcattctctt tcacctgagt aaataacata tccttcaaat tagtttgtct    780

catattttcc agtcttccta gactgtattt aagagtacaa agcatatagt tagcactata    840

ctatacagtt gtgtctactt atatagtaat tatccttaac gtccaaagtt aagttcttga    900

aatccaggta aaattcgcat ttgaggaatt taaaatggca aaatgacatc aaggaaccaa    960

agccagaagt aaacctaaaa acacctttat acttttatac tcactgtaat gaaacagaaa   1020

tgactgtaca ctaaactcat accctgtatt agtctgttct cacactgctg taaagaacta   1080

cctgagactg ggtaatttat gaaggaaaga ggtttaattg actcacagtt ccacaggctt   1140

aacaggaagc atgactggga ggcctcagga aacttaaaat tttggcagca ggtgaagggg   1200

aagcaagcac cttcttcaca tgatggcagg agagagagag caaagtggga agtgccacac   1260

acttttaaac catcagatct catgagaagt cactatcacg agaacggcaa gggggaaatc   1320

cacccccatg atccaatcac ctcccaccag ggtcctcctc caatttgaca tgagatttgg   1380

gtggggatac aaatccaaac catatcatag tccatcagtg acattttata taaattaaca   1440

ttttgttttc tgctgtatct cagtacctat aacattacct ggcacatagt aaatgctcaa   1500

taattatttg ttcaaccaat gaataatatg catttcactt atcactagtt cagtatttgt   1560

gttctctaca atttcagatc tttatcttgt gaattgtttt tgctttgatg caaataactt   1620

tttttttttg ctttttgttt agttcttgag atgtttaaaa tatttctgat tttatgttta   1680

acagatacgt tggtgtcctc tctctctgat tattcctagg gattccctct tatcagctac   1740

atttacctat ctcagctcta tcacttgatc atcgtatgtt ctaaagccca ggcgtacttt   1800

tcttatcttt ctctaggctt tattgtaata tatctctgct ttatctgcat ttccactttg   1860

cctccttttt ctcttctata cctttttctg ccctatgaca ggaccatctg cttccccttt   1920

cataattcat ctcagtggta atttcatgtt taatttcctt ctttcctcta agaatggagg   1980

ttctgtgagg acaaggatta ccctcatctt atttcccact gttggtccag tgcatgaggc   2040

actacctgat acactgtcag gctcctggta gatagtaagt ctttgttgaa tgattaatct   2100

gtctttgatt ctccctgttt tttccctgtg tttatatcac caacagcatt taccactcct   2160

atattgagag caaattcttg agagagccaa aaaggttttt ggaagtaaaa aggtttttag   2220

atgtacttga atttcaaata aggagatgct atatattctt tgaggtggta catgcagtgg   2280

tttaaaaaac atagtatttt aggatttgaa gccaacttgc tgattaaatt atataggcaa   2340

gccttttaac catgctgagc ctctttattt atctgaagtg aagatgatat tattgccttg   2400

cctacatcac aggattgtca aaaagataaa ataaaattag ataaaattgt gtatgaaacc   2460

tataaagtac catataagta ttagtcatta gttatacttt cctaatctac gttgagtatt   2520

tgtatgtatt gtgtgtgtag cttttcttac tctttatttg catcagtcat agcccctaac   2580

atggcgttga accttggcta tttcttctgc agctgcttta tttttactgc tcagcagatc   2640

cctggatttg ttggctcctc atgagctttt gtggattttt ctgccgtgtt atagatcgca   2700

tgttgtgtct actctcagtt tctgtatcat agtcagctgg tagtgattct acaggttaga   2760

gttgaagtgc ctactcattc agcctttgtc taaagaatct ttgaactctg gcttgaaaag   2820

tcagagtagg acagttctta tgaaccggtc cctattactt ttttagtgca catggttaat   2880

caatcagtaa gattatattg tgtttcttag ttatttcatt tttgctctct gatacaaaaa   2940

aggattagaa aatgatagtt tgactttcag acttttaaga acaggcatca aagaaggaga   3000

acaaagaggt accatgatct ctgctctttc taggagggtc tctaccttta tcctatgtgt   3060

ataattccat tctgagcagc tcggaggaac atataagtca cggtgttttc atattttatt   3120

aaaaagaaat aataacattt gtatggaatc atattgctaa agcatgcaaa agaattgtac   3180

cttattcatg agtcactttt atgggtttca atttcaaaaa gactgactag gtgcagtggc   3240

tcacgcctgt aatcccagca cttgggaggc tgagacgggt ggatcacttg aggccaggag   3300

ttcgagacta ccctggccaa catggtgaaa ccccgtctgt acgaaaaata caaaaatttg   3360

cttggcatgg tggtgcacac ctgtaatccc agctacttgg gtaactgaag catgagaatc   3420

acttgaacct gggaggcgga ggtcgcagtg agccaagatt gtgccactgt actgcacttc   3480

agcctgggtg acagagtaag actgtctc                                      3508


<210>  1819
<211>  102
<212>  PRT
<213>  Homo sapiens

<400>  1819


Met Pro Leu Arg Leu Asp Ile Lys Arg Lys Leu Thr Ala Arg Ser Asp 
1               5                   10                  15      


Arg Val Lys Ser Val Asp Leu His Pro Thr Glu Pro Trp Met Leu Ala 
            20                  25                  30          


Ser Leu Tyr Asn Gly Ser Val Cys Val Trp Asn His Glu Thr Gln Val 
        35                  40                  45              


Gly Ile Phe Gln Asp Cys Ile Arg Asn Lys Ile Leu Cys Glu Thr Val 
    50                  55                  60                  


Phe Ile Met Lys Glu Lys Lys Tyr Tyr Asn Arg Ile Gln Asn Leu Tyr 
65                  70                  75                  80  


Ala Asn Cys Phe Leu Lys Leu Val Gln Ser Ile Leu Asn Met Lys Glu 
                85                  90                  95      


Leu Thr Phe Met Arg Gly 
            100         

<210>  1820
<211>  186
<212>  DNA
<213>  Homo sapiens

<400>  1820
aggggtgtgg cctagaccac taagggccgt gacgtggtgc cgctgagctt ggaccccgac     60

cagaagatag agattgaaac gatgaggaaa acgaagtgcc taatccccgc tggacgctaa    120

ctgcagggca agatggagga gacatatttc cacctatttc tctccataag tataaaagac    180

cataaa                                                               186


<210>  1821
<211>  35
<212>  PRT
<213>  Homo sapiens

<400>  1821


Asn Asp Glu Glu Asn Glu Val Pro Asn Pro Arg Trp Thr Leu Thr Ala 
1               5                   10                  15      


Gly Gln Asp Gly Gly Asp Ile Phe Pro Pro Ile Ser Leu His Lys Tyr 
            20                  25                  30          


Lys Arg Pro 
        35  

<210>  1822
<211>  776
<212>  DNA
<213>  Homo sapiens

<400>  1822
aggggtgtgg cctagaccac taagggccgt gacgtggtgc cgctgagctt ggaccccgac     60

cagaagatag agattgaaac gatgaggaaa acgaagtgcc taatccccgc tggacgctaa    120

ctgcagggca agctccccag tgttgtagtt gtgtttcgga ggccgagaac cgctatcggg    180

cttcctcgga ctctggccct ggagggggga aacggcgagg gagaaggcga aacgagtctc    240

cagtgtgttc ttggggcctg gtgcgaggcc cagagaattc tctgcaggcc tttgcccggg    300

cactgattaa ggctgcgaag agacgcaccg ggctgcgggc ttagtagctt caggcttctg    360

aagtcagagg gagggctgag agcttacact tctggagctc cccgggagac ggcaactacc    420

caaccgtgtg ggtgtgtttg tcacccagaa atactctcca caccatgctg cactgctgcg    480

gatgagggaa ggatggtgtc ggggcttcaa gactgttttt cctacctctt cagtgcctct    540

ttcagtgata tgaagttaaa accagttaat ttgcaggttc tccctctgcc tgccacccca    600

cccagcaagg aggagaggaa gtgttgagaa gggaagagat gagtcctggc cctgtcactt    660

cttaggggtg tgcttttgaa caacctgctc accatgtatg aacttcactc ttcttgttta    720

taaaatgagg acaatgacac ctgcaagact gtgaggttta aaaacaaaat ctgtgt        776


<210>  1823
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  1823


Met Val Ser Gly Leu Gln Asp Cys Phe Ser Tyr Leu Phe Ser Ala Ser 
1               5                   10                  15      


Phe Ser Asp Met Lys Leu Lys Pro Val Asn Leu Gln Val Leu Pro Leu 
            20                  25                  30          


Pro Ala Thr Pro Pro Ser Lys Glu Glu Arg Lys Cys 
        35                  40                  

<210>  1824
<211>  975
<212>  DNA
<213>  Homo sapiens

<400>  1824
aggggtgtgg cctagaccac taagggccgt gacgtggtgc cgctgagctt ggaccccgac     60

cagaagatag agattgaaac gatgaggaaa acgaagtgcc taatccccgc tggacgctaa    120

ctgcagggca agctccccag tgttgtagtt gtgtttcgga ggccgagaac cgctatcggg    180

cttcctcgga ctctggccct ggagggggga aacggcgagg gagaaggcga aacgagtctc    240

cagtgtgttc ttggggcctg gtgcgaggcc cagagaattc tctgcaggcc tttgcccggg    300

cactgattaa ggctgcgaag agacgcaccg ggctgcgggc ttagtagctt caggcttctg    360

aagtcagagg gagggctgag agcttacact tctggagctc cccgggagac ggcaactacc    420

caaccgtgtg ggtgtgtttg tcacccagaa atactctcca caccatgctg cactgctgcg    480

gatgagggaa ggatggtgtc ggggcttcaa gactgttttt cctacctctt cagtgcctct    540

ttcagtgata tgaagttaaa accaggaaca tggaggagac atatttccac ctatttctct    600

ccataagtat aaaagaccat aaaagaccat ctagggactt cagaacccaa ataatgacac    660

aatgttaatt tgcaggttct ccctctgcct gccaccccac ccagcaagga ggagaggaag    720

tgttgagaag ggaagagatg agtcctggcc ctgtcacttc ttaggggtgt gcttttgaac    780

aacctgctca ccatgtatga acttcactct tcttgtttat aaaatgagga caatgacacc    840

tgcaagactg tgaggtttaa aaacaaaatc tgtgttgaga ggtaacttgc ctcttttact    900

taccaatgat ttcctcaatg cctggtgact ggggctggtt catactagac gatcaataaa    960

tgctccttga atgaa                                                     975


<210>  1825
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  1825


Met Leu Ile Cys Arg Phe Ser Leu Cys Leu Pro Pro His Pro Ala Arg 
1               5                   10                  15      


Arg Arg Gly Ser Val Glu Lys Gly Arg Asp Glu Ser Trp Pro Cys His 
            20                  25                  30          


Phe Leu Gly Val Cys Phe 
        35              

<210>  1826
<211>  851
<212>  DNA
<213>  Homo sapiens

<400>  1826
aggggtgtgg cctagaccac taagggccgt gacgtggtgc cgctgagctt ggaccccgac     60

cagaagatag agattgaaac gatgaggaaa acgaagtgcc taatccccgc tggacgctaa    120

ctgcagggca agctccccag tgttgtagtt gtgtttcgga ggccgagaac cgctatcggg    180

cttcctcgga ctctggccct ggagggggga aacggcgagg gagaaggcga aacgagtctc    240

cagtgtgttc ttggggcctg gtgcgaggcc cagagaattc tctgcaggcc tttgcccggg    300

cactgattaa ggctgcgaag agacgcaccg ggctgcgggc ttagtagctt caggcttctg    360

aagtcagagg gagggctgag agcttacact tctggagctc cccgggagac ggcaactacc    420

caaccgtgtg ggtgtgtttg tgaacatgga ggagacatat ttccacctat ttctctccat    480

aagtataaaa gaccataaaa gaccatctag ggacttcaga acccaaataa tgacacaatg    540

ttaatttgca ggttctccct ctgcctgcca ccccacccag caaggaggag aggaagtgtt    600

gagaagggaa gagatgagtc ctggccctgt cacttcttag gggtgtgctt ttgaacaacc    660

tgctcaccat gtatgaactt cactcttctt gtttataaaa tgaggacaat gacacctgca    720

agactgtgag gtttaaaaac aaaatctgtg ttgagaggta acttgcctct tttacttacc    780

aatgatttcc tcaatgcctg gtgactgggg ctggttcata ctagacgatc aataaatgct    840

ccttgaatga a                                                         851


<210>  1827
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  1827


Met Leu Ile Cys Arg Phe Ser Leu Cys Leu Pro Pro His Pro Ala Arg 
1               5                   10                  15      


Arg Arg Gly Ser Val Glu Lys Gly Arg Asp Glu Ser Trp Pro Cys His 
            20                  25                  30          


Phe Leu Gly Val Cys Phe 
        35              

<210>  1828
<211>  139
<212>  DNA
<213>  Homo sapiens

<400>  1828
ccaggaacat ggaggagaca tatttccacc tatttctctc cataagtata aaagaccata     60

aagttaattt gcaggttctc cctctgcctg ccaccccacc cagcaaggag gagaggaagt    120

gttgagaagg gaagagatg                                                 139


<210>  1829
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  1829


Met Glu Glu Thr Tyr Phe His Leu Phe Leu Ser Ile Ser Ile Lys Asp 
1               5                   10                  15      


His Lys Val Asn Leu Gln Val Leu Pro Leu Pro Ala Thr Pro Pro Ser 
            20                  25                  30          


Lys Glu Glu Arg Lys Cys 
        35              

<210>  1830
<211>  815
<212>  DNA
<213>  Homo sapiens

<400>  1830
ctgctgcagt cagatgctcc caaggacagc agtctccaga aagcttcttg taacctggaa     60

agattggtta tagttgatca ttttcctcca tcttaaaagt cacctgaaga attccacaag    120

gacttagcct gctccttgcc atccaccaca aaccctcacc gaaccagtgg ccaccaccat    180

gacaagggac cagaatggaa cctgggagat ggagagtaat gaaaactttg agggctacat    240

gaaggccctg gatattgatt ttgccacccg caagattgca gtacgtctca ctcagacgaa    300

ggttattgat caagatggtg ataacttcaa gacaaaaacc actagcacat tccgcaacta    360

tgatgtggat ttcactgttg gagtagagtt tgacgagtac acaaagagcc tggataaccg    420

gcatgttaag gcactggtca cctgggaagg tgatgtcctt gtgtgtgtgc aaaaggggga    480

gaaggagaac cgcggctgga agcagtggat tgagggggac aagctgtacc tggagctgac    540

ctgtggtgac caggtgtgcc gtcaagtgtt caaaaagaaa tgatggcgac gtgggaggcc    600

tgccaagcac aagctcccca ctgcccacac tgagtggtct actggctttg agaaacagct    660

gtggggacct tcccactctt gacagagccc cattaaggca tctgggtggg ttttaaacag    720

aatgcctatg tagcagtgat agacatattc ccctcctttg aaacctagca ttaaatggaa    780

aaacaaaaat tactcccata ttttgaaacc cttta                               815


<210>  1831
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  1831


Met Thr Arg Asp Gln Asn Gly Thr Trp Glu Met Glu Ser Asn Glu Asn 
1               5                   10                  15      


Phe Glu Gly Tyr Met Lys Ala Leu Asp Ile Asp Phe Ala Thr Arg Lys 
            20                  25                  30          


Ile Ala Val Arg Leu Thr Gln Thr Lys Val Ile Asp Gln Asp Gly Asp 
        35                  40                  45              


Asn Phe Lys Thr Lys Thr Thr Ser Thr Phe Arg Asn Tyr Asp Val Asp 
    50                  55                  60                  


Phe Thr Val Gly Val Glu Phe Asp Glu Tyr Thr Lys Ser Leu Asp Asn 
65                  70                  75                  80  


Arg His Val Lys Ala Leu Val Thr Trp Glu Gly Asp Val Leu Val Cys 
                85                  90                  95      


Val Gln Lys Gly Glu Lys Glu Asn Arg Gly Trp Lys Gln Trp Ile Glu 
            100                 105                 110         


Gly Asp Lys Leu Tyr Leu Glu Leu Thr Cys Gly Asp Gln Val Cys Arg 
        115                 120                 125             


Gln Val Phe Lys Lys Lys 
    130                 

<210>  1832
<211>  744
<212>  DNA
<213>  Homo sapiens

<400>  1832
tagggagcca gcccaggagc ccagctgctg cagtcagatg ctcccaagga cagcagcctg     60

ctccttgcca tccaccacaa accctcaccg aaccagtggc caccaccatg acaagggacc    120

agaatggaac ctgggagatg gagagtaatg aaaactttga gggctacatg aaggccctgg    180

atattgattt tgccacccgc aagattgcag tacgtctcac tcagacgaag gttattgatc    240

aagatggtga taacttcaag acaaaaacca ctagcacatt ccgcaactat gatgtggatt    300

tcactgttgg agtagagttt gacgagtaca caaagagcct ggataaccgg catgttaagg    360

cactggtcac ctgggaaggt gatgtccttg tgtgtgtgca aaagggggag aaggagaacc    420

gcggctggaa gcagtggatt gagggggaca agctgtacct ggagctgacc tgtggtgacc    480

aggtgtgccg tcaagtgttc aaaaagaaat gatggcgacg tgggaggcct gccaagcaca    540

agctccccac tgcccacact gagtggtcta ctggctttga gaaacagctg tggggacctt    600

cccactcttg acagagcccc attaaggcat ctgggtgggt tttaaacaga atgcctatgt    660

agcagtgata gacatattcc cctcctttga aacctagcat taaatggaaa aacaaaaatt    720

actcccatat tttgaaaccc ttta                                           744


<210>  1833
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  1833


Met Thr Arg Asp Gln Asn Gly Thr Trp Glu Met Glu Ser Asn Glu Asn 
1               5                   10                  15      


Phe Glu Gly Tyr Met Lys Ala Leu Asp Ile Asp Phe Ala Thr Arg Lys 
            20                  25                  30          


Ile Ala Val Arg Leu Thr Gln Thr Lys Val Ile Asp Gln Asp Gly Asp 
        35                  40                  45              


Asn Phe Lys Thr Lys Thr Thr Ser Thr Phe Arg Asn Tyr Asp Val Asp 
    50                  55                  60                  


Phe Thr Val Gly Val Glu Phe Asp Glu Tyr Thr Lys Ser Leu Asp Asn 
65                  70                  75                  80  


Arg His Val Lys Ala Leu Val Thr Trp Glu Gly Asp Val Leu Val Cys 
                85                  90                  95      


Val Gln Lys Gly Glu Lys Glu Asn Arg Gly Trp Lys Gln Trp Ile Glu 
            100                 105                 110         


Gly Asp Lys Leu Tyr Leu Glu Leu Thr Cys Gly Asp Gln Val Cys Arg 
        115                 120                 125             


Gln Val Phe Lys Lys Lys 
    130                 

<210>  1834
<211>  272
<212>  DNA
<213>  Homo sapiens

<400>  1834
cccttcctta aaattgctac aagccactga agagcatctt ccttgttcta tgtgtccagc     60

ttcagtctcg tcgctggaca tttggttcca gatctaaagc agcagagggc agtggccgta    120

tgtggagctg ttattaactg catcaccttg ttgtgaggat caaatttgat ggtgtttgtg    180

aagagctttg cccagtggct ggcagcctgt gatcatggct ctgtaaatgg aggctgccat    240

catcataata tcattatgaa gcccctgatc tc                                  272


<210>  1835
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  1835


Met Val Phe Val Lys Ser Phe Ala Gln Trp Leu Ala Ala Cys Asp His 
1               5                   10                  15      


Gly Ser Val Asn Gly Gly Cys His His His Asn Ile Ile Met Lys Pro 
            20                  25                  30          


Leu 
    

<210>  1836
<211>  542
<212>  DNA
<213>  Homo sapiens

<400>  1836
tcagaagtat aaatttgccc ttggcaaatg catacacctc atgctaccct cacaaaactg     60

gaatagcctt cacaaagaaa ttgtccttga aggttgtgtc tgatataagc actggattgt    120

agaacttgtt gctgattttg accttgtatt caagttaact gttccccttg gtattaatgt    180

gtcagggccg agtgttctgg aatttctcta gaggctcgca tgggctcctg aaccaattgt    240

ttctgtcctg ctggtctgtc tgtcagggtt ggaaaagtcc aagccatagg acccagtttt    300

ctttcttagc tgatgttttc ctgctagaac accatggact gttacttgcc ttgagttgga    360

agtagtttgc atttatacct gtaaatatat ttatcctttt aatttatgta aggttttttt    420

tttgtatgca attctggatt ctttaaagag atgacaatga attttggttt tctactgtta    480

tgtgagaaca tcagtcccca gcaacacgtc attgtgtaag tagaaataaa agcgctgctg    540

tt                                                                   542


<210>  1837
<211>  62
<212>  PRT
<213>  Homo sapiens

<400>  1837


Met Cys Gln Gly Arg Val Phe Trp Asn Phe Ser Arg Gly Ser His Gly 
1               5                   10                  15      


Leu Leu Asn Gln Leu Phe Leu Ser Cys Trp Ser Val Cys Gln Gly Trp 
            20                  25                  30          


Lys Ser Pro Ser His Arg Thr Gln Phe Ser Phe Leu Ala Asp Val Phe 
        35                  40                  45              


Leu Leu Glu His His Gly Leu Leu Leu Ala Leu Ser Trp Lys 
    50                  55                  60          

<210>  1838
<211>  462
<212>  DNA
<213>  Homo sapiens

<400>  1838
tgaaattgac gtgagcacat cccagattat caagtttggg agctgccccc tcccccagcc     60

tccaggagct ccccgcttgc tcaggattga caaatgtgtc tctttcttgg cagacaacag    120

tgagctggga cggagacaag ctccagtgtg tgcagaaggg tgagaaggag gggcgtggct    180

ggacccagtg gatcgagggt gatgagctgc acctggagat gagagtggaa ggtgtggtct    240

gcaagcaagt attcaagaag gtgcagtgag gcccaggcag acaaccttgt cccaaggaat    300

cagcaggatg tgtgggccag gatccccctc tttgcacagc atgaggcaaa aatgtccagc    360

cacccccagg catctgttag cagagtctgt ctcttggctt tgtcactttt ccttttctta    420

aaacaaagcc atgccaataa agtgatctgt gttcaaaacg tc                       462


<210>  1839
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  1839


Met Cys Gly Pro Gly Ser Pro Ser Leu His Ser Met Arg Gln Lys Cys 
1               5                   10                  15      


Pro Ala Thr Pro Arg His Leu Leu Ala Glu Ser Val Ser Trp Leu Cys 
            20                  25                  30          


His Phe Ser Phe Ser 
        35          

<210>  1840
<211>  273
<212>  DNA
<213>  Homo sapiens

<400>  1840
accatatgat catccgcacg ctgagcactt ttaggaacta catcatggac ttccaggttg     60

ggaaggagtt tgaggaggat ctgacaggca gacaaccttg tcccaaggaa tcagcaggat    120

gtgtgggcca ggatccccct ctttgcacag catgaggcaa aaatgtccag ccacccccag    180

gcatctgtta gcagagtctg tctcttggct ttgtcacttt tccttttctt aaaacaaagc    240

catgccaata aagtgatctg tgttcaaaac gtc                                 273


<210>  1841
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  1841


Met Ile Ile Arg Thr Leu Ser Thr Phe Arg Asn Tyr Ile Met Asp Phe 
1               5                   10                  15      


Gln Val Gly Lys Glu Phe Glu Glu Asp Leu Thr Gly Arg Gln Pro Cys 
            20                  25                  30          


Pro Lys Glu Ser Ala Gly Cys Val Gly Gln Asp Pro Pro Leu Cys Thr 
        35                  40                  45              


Ala 
    

<210>  1842
<211>  889
<212>  DNA
<213>  Homo sapiens

<400>  1842
gaacgtctga aacgaaggtg gcgcggcctg gacaaacctg acccttcgac atcccccgcc     60

cctgcgcccg ccctcgctaa gcggggagga gcgaccgcta caatggatcc tcccgcaggc    120

tttgtgcgcg ctgggaatcc agctgtcgcc gccccgcaga gccccctgtc cccggagggc    180

gctcatttcc gggccgccca ccacccgcgt agcaccggca gccgctgtcc cggcagtctc    240

cagccgtccc gcccgcttgt ggccaactgg ctccagtcac tccccgaaat gccagtcgac    300

ttcactgggt actggaagat gttggtcaac gagaatttcg aggagtacct gcgcgccctc    360

gacgtcaatg tggccttgcg caaaatcgcc aacttgctga agccagacaa agagatcgtg    420

caggacggtg accatatgat catccgcacg ctgagcactt ttaggaacta catcatggac    480

ttccaggttg ggaaggagtt tgaggaggat ctgacaggca tagatgaccg caagtgcatg    540

acaacagtga gctgggacgg agacaagctc cagtgtgtgc agaagggtga gaaggagggg    600

cgtggctgga cccagtggat cgagggtgat gagctgcacc tggagatgag agtggaaggt    660

gtggtctgca agcaagtatt caagaaggtg cagtgaggcc caggcagaca accttgtccc    720

aaggaatcag caggatgtgt gggccaggat ccccctcttt gcacagcatg aggcaaaaat    780

gtccagccac ccccaggcat ctgttagcag agtctgtctc ttggctttgt cacttttcct    840

tttcttaaaa caaagccatg ccaataaagt gatctgtgtt caaaacgtc                889


<210>  1843
<211>  197
<212>  PRT
<213>  Homo sapiens

<400>  1843


Met Asp Pro Pro Ala Gly Phe Val Arg Ala Gly Asn Pro Ala Val Ala 
1               5                   10                  15      


Ala Pro Gln Ser Pro Leu Ser Pro Glu Gly Ala His Phe Arg Ala Ala 
            20                  25                  30          


His His Pro Arg Ser Thr Gly Ser Arg Cys Pro Gly Ser Leu Gln Pro 
        35                  40                  45              


Ser Arg Pro Leu Val Ala Asn Trp Leu Gln Ser Leu Pro Glu Met Pro 
    50                  55                  60                  


Val Asp Phe Thr Gly Tyr Trp Lys Met Leu Val Asn Glu Asn Phe Glu 
65                  70                  75                  80  


Glu Tyr Leu Arg Ala Leu Asp Val Asn Val Ala Leu Arg Lys Ile Ala 
                85                  90                  95      


Asn Leu Leu Lys Pro Asp Lys Glu Ile Val Gln Asp Gly Asp His Met 
            100                 105                 110         


Ile Ile Arg Thr Leu Ser Thr Phe Arg Asn Tyr Ile Met Asp Phe Gln 
        115                 120                 125             


Val Gly Lys Glu Phe Glu Glu Asp Leu Thr Gly Ile Asp Asp Arg Lys 
    130                 135                 140                 


Cys Met Thr Thr Val Ser Trp Asp Gly Asp Lys Leu Gln Cys Val Gln 
145                 150                 155                 160 


Lys Gly Glu Lys Glu Gly Arg Gly Trp Thr Gln Trp Ile Glu Gly Asp 
                165                 170                 175     


Glu Leu His Leu Glu Met Arg Val Glu Gly Val Val Cys Lys Gln Val 
            180                 185                 190         


Phe Lys Lys Val Gln 
        195         

<210>  1844
<211>  1350
<212>  DNA
<213>  Homo sapiens

<400>  1844
gaacgtctga aacgaaggtg gcgcggcctg gacaaacctg acccttcgac atcccccgcc     60

cctgcgcccg ccctcgctaa gcggggagga gcgaccgcta caatggatcc tcccgcaggc    120

tttgtgcgcg ctgggaatcc agctgtcgcc gccccgcaga gccccctgtc cccggagggc    180

gctcatttcc gggccgccca ccacccgcgt agcaccggca gccgctgtcc cggcagtctc    240

cagccgtccc gcccgcttgt ggccaactgg ctccagtcac tccccgaaat gccagtcgac    300

ttcactgggt actggaagat gttggtcaac gagaatttcg aggagtacct gcgcgccctc    360

gacgtcaatg tggccttgcg caaaatcgcc aacttgctga agccagacaa agagatcgtg    420

caggacggtg accatatgat catccgcacg ctgagcactt ttaggaacta catcatggac    480

ttccaggttg ggaaggagtt tgaggaggat ctgacaggca tagatgaccg caagtgcatg    540

gctggagtgc aatcgcgtga tctcagctca ctgtaacctc tgcctcccgg gttcaagcaa    600

ttctcctgcc tcagcctccc aagtagctgg gattacagtc acacgccacc acacctggat    660

aattttgtat ttttggtaga gacagggttt cactatgttg gtcaggctgg tctcaaactc    720

ctgagctcag gtgatccatc tgcctcagcc tcccaaaatg ctgggattac aagtgtgagc    780

cactacacct ggttcttctt tccactgttt gctaactccc atggtgtttt ctggcatcac    840

ttccagcatt atttctagcc ttacctcttc caggaagcct tccctgatgg gcctctgtct    900

ctaccttaaa ggctgtcgag gtgccttctg acttccataa cctccagcat ttgtctacca    960

gtacttacca ttctgctgga attctctgtc ttcttacctt cttctcagat aatctgtgag   1020

ccctcaagag caggccactg accttacttc cctctctcca gcacctacag ctggtgcata   1080

ggaggtgtga aacccatgat tgctgaatgc cgttcccttg cacagaacca cgtggtgaat   1140

tcctattgct cagtcaaggg tcagtttaaa gcagggaact gcagagcaca gtcatcaaga   1200

gcatgagctc tagagccaaa tctcatctcc ccacttcacg gctgggtgaa cttcaggcct   1260

cagtctccac atttgtaaaa tgatgagaag catacctgct ctaggaggtt gtcaggagtc   1320

aactggtatg acatatactt tgcctagtac                                    1350


<210>  1845
<211>  157
<212>  PRT
<213>  Homo sapiens

<400>  1845


Met Asp Pro Pro Ala Gly Phe Val Arg Ala Gly Asn Pro Ala Val Ala 
1               5                   10                  15      


Ala Pro Gln Ser Pro Leu Ser Pro Glu Gly Ala His Phe Arg Ala Ala 
            20                  25                  30          


His His Pro Arg Ser Thr Gly Ser Arg Cys Pro Gly Ser Leu Gln Pro 
        35                  40                  45              


Ser Arg Pro Leu Val Ala Asn Trp Leu Gln Ser Leu Pro Glu Met Pro 
    50                  55                  60                  


Val Asp Phe Thr Gly Tyr Trp Lys Met Leu Val Asn Glu Asn Phe Glu 
65                  70                  75                  80  


Glu Tyr Leu Arg Ala Leu Asp Val Asn Val Ala Leu Arg Lys Ile Ala 
                85                  90                  95      


Asn Leu Leu Lys Pro Asp Lys Glu Ile Val Gln Asp Gly Asp His Met 
            100                 105                 110         


Ile Ile Arg Thr Leu Ser Thr Phe Arg Asn Tyr Ile Met Asp Phe Gln 
        115                 120                 125             


Val Gly Lys Glu Phe Glu Glu Asp Leu Thr Gly Ile Asp Asp Arg Lys 
    130                 135                 140                 


Cys Met Ala Gly Val Gln Ser Arg Asp Leu Ser Ser Leu 
145                 150                 155         

<210>  1846
<211>  569
<212>  DNA
<213>  Homo sapiens

<400>  1846
agctcagctg gagtgcaagc tgggaatgca gtcaaggctt catccacccc aggcagcttt     60

cctgagcctt gggagactgg ctctcaatga atccaagctg cttttatcct ttgctgccta    120

tctagtcttg ttaacaacaa agaagaggag aatggagatt gagcaaccag gaagcagtct    180

cagccacacc atcatatgga gaagtgcctg tttcccattc tgcccgattt taagtttcct    240

gaggcacccc cagccatgca gaactctctg gtgcctggcc cacaggaagt tttcactaaa    300

tattgaaata aactgaactt agattaaact ttggtgtcta acttaggaaa aacaacaaga    360

gttctacaaa actatttctt cacaggaaag tctgaagcca ggcctgctta gcagaggtct    420

ccgtatagta gggatctcac tctttcaaga tgtaggatct caactggtta gccagccctc    480

tgagtgaagc tggtcagttg gggctgtgac aacatagcac actcaaaggg gcagaccctt    540

ctcagctcca acagattggt gtcattgga                                      569


<210>  1847
<211>  96
<212>  PRT
<213>  Homo sapiens

<400>  1847


Met Gln Ser Arg Leu His Pro Pro Gln Ala Ala Phe Leu Ser Leu Gly 
1               5                   10                  15      


Arg Leu Ala Leu Asn Glu Ser Lys Leu Leu Leu Ser Phe Ala Ala Tyr 
            20                  25                  30          


Leu Val Leu Leu Thr Thr Lys Lys Arg Arg Met Glu Ile Glu Gln Pro 
        35                  40                  45              


Gly Ser Ser Leu Ser His Thr Ile Ile Trp Arg Ser Ala Cys Phe Pro 
    50                  55                  60                  


Phe Cys Pro Ile Leu Ser Phe Leu Arg His Pro Gln Pro Cys Arg Thr 
65                  70                  75                  80  


Leu Trp Cys Leu Ala His Arg Lys Phe Ser Leu Asn Ile Glu Ile Asn 
                85                  90                  95      

<210>  1848
<211>  1383
<212>  DNA
<213>  Homo sapiens

<400>  1848
atggatatgg aggtcttggg ccaggaacaa agctccgaac agctggattt agaggagatc     60

tcaaggaaaa tttcattcct tgacaaatgg agggaaatct ttagttatca caggttggga    120

accaataatt caactcctca gaatcatgaa ggcaaccata catctgctga tgaaaatgaa    180

gatggaacag gactatctca gcccaaagga caaggacatt tgccatcaag tggcctttgt    240

tctattccca acccctctat catctcttca aaattgggtg gctttcctat ctccctagca    300

atggccacga agctgcggca gatcctgttt ggaaacacag tccatgtctt tagctataac    360

tggaaaaagg cctatttcag gttccatgat ccttcttctg aactagcttt cactctggaa    420

gtgggaaagg gaggggcccg aagcattcag atggctgtgc aaggatccat catcaaatac    480

ttgttgttta ccaggaaagg aaaagactgt aaccttggca acttatgtga aataagcaag    540

aaggagcagg agcaagcctt ggccgcggcg cttgctggca tcctgtgggc tgcaggagca    600

gctcagaagg ccaccatctg tcttgtcact gaggacattt acgttgcgtc gactccggac    660

tactctgtgg acaatttcac tgagcgactc cagctgtttg aatttttaga gaaagaagcc    720

gctgagaaat tcatctacga tcacttacta tgtttcagag gggaaggaag ccatggtgtc    780

atcctgtttc tgtacagcct gatcttctct agaacatttg aaaggcttca aatggaccta    840

gatgtcacca ccactcagct gctacaacca aatgctggag gctttctgtg caggcaggca    900

gttctgaaca tgattttaac tggaagagca agtcccaatg tcttcaatgg ctgtgaggaa    960

ggaaagtctc aggaaacact acatggagtc ctgacccgca gtgatgttgg ctatttgcag   1020

tggggtaagg atgcctcgga agatgacaga ctctcacagg tgggcagcat gctgaagact   1080

cccaaattac ctatttggct gtgcaacatc aatggaaatt acagcatcct tttttgcaca   1140

aacaggcagc tcttatcaga ctggaaaatg gaacgtctct ttgatctgta cttttacagt   1200

ggccaaccct cacagaaaaa gcttgtgcgt cttacaatag atactcactc ccatcactgg   1260

gaaagagacc aacaggaaga gaaacatgga ccaagacgac ggttttcacc agtggagatg   1320

gcaatcagaa ccaagtggag cgaggccacc atcaactgga atgggaccgt tcccttcttc   1380

taa                                                                 1383


<210>  1849
<211>  460
<212>  PRT
<213>  Homo sapiens

<400>  1849


Met Asp Met Glu Val Leu Gly Gln Glu Gln Ser Ser Glu Gln Leu Asp 
1               5                   10                  15      


Leu Glu Glu Ile Ser Arg Lys Ile Ser Phe Leu Asp Lys Trp Arg Glu 
            20                  25                  30          


Ile Phe Ser Tyr His Arg Leu Gly Thr Asn Asn Ser Thr Pro Gln Asn 
        35                  40                  45              


His Glu Gly Asn His Thr Ser Ala Asp Glu Asn Glu Asp Gly Thr Gly 
    50                  55                  60                  


Leu Ser Gln Pro Lys Gly Gln Gly His Leu Pro Ser Ser Gly Leu Cys 
65                  70                  75                  80  


Ser Ile Pro Asn Pro Ser Ile Ile Ser Ser Lys Leu Gly Gly Phe Pro 
                85                  90                  95      


Ile Ser Leu Ala Met Ala Thr Lys Leu Arg Gln Ile Leu Phe Gly Asn 
            100                 105                 110         


Thr Val His Val Phe Ser Tyr Asn Trp Lys Lys Ala Tyr Phe Arg Phe 
        115                 120                 125             


His Asp Pro Ser Ser Glu Leu Ala Phe Thr Leu Glu Val Gly Lys Gly 
    130                 135                 140                 


Gly Ala Arg Ser Ile Gln Met Ala Val Gln Gly Ser Ile Ile Lys Tyr 
145                 150                 155                 160 


Leu Leu Phe Thr Arg Lys Gly Lys Asp Cys Asn Leu Gly Asn Leu Cys 
                165                 170                 175     


Glu Ile Ser Lys Lys Glu Gln Glu Gln Ala Leu Ala Ala Ala Leu Ala 
            180                 185                 190         


Gly Ile Leu Trp Ala Ala Gly Ala Ala Gln Lys Ala Thr Ile Cys Leu 
        195                 200                 205             


Val Thr Glu Asp Ile Tyr Val Ala Ser Thr Pro Asp Tyr Ser Val Asp 
    210                 215                 220                 


Asn Phe Thr Glu Arg Leu Gln Leu Phe Glu Phe Leu Glu Lys Glu Ala 
225                 230                 235                 240 


Ala Glu Lys Phe Ile Tyr Asp His Leu Leu Cys Phe Arg Gly Glu Gly 
                245                 250                 255     


Ser His Gly Val Ile Leu Phe Leu Tyr Ser Leu Ile Phe Ser Arg Thr 
            260                 265                 270         


Phe Glu Arg Leu Gln Met Asp Leu Asp Val Thr Thr Thr Gln Leu Leu 
        275                 280                 285             


Gln Pro Asn Ala Gly Gly Phe Leu Cys Arg Gln Ala Val Leu Asn Met 
    290                 295                 300                 


Ile Leu Thr Gly Arg Ala Ser Pro Asn Val Phe Asn Gly Cys Glu Glu 
305                 310                 315                 320 


Gly Lys Ser Gln Glu Thr Leu His Gly Val Leu Thr Arg Ser Asp Val 
                325                 330                 335     


Gly Tyr Leu Gln Trp Gly Lys Asp Ala Ser Glu Asp Asp Arg Leu Ser 
            340                 345                 350         


Gln Val Gly Ser Met Leu Lys Thr Pro Lys Leu Pro Ile Trp Leu Cys 
        355                 360                 365             


Asn Ile Asn Gly Asn Tyr Ser Ile Leu Phe Cys Thr Asn Arg Gln Leu 
    370                 375                 380                 


Leu Ser Asp Trp Lys Met Glu Arg Leu Phe Asp Leu Tyr Phe Tyr Ser 
385                 390                 395                 400 


Gly Gln Pro Ser Gln Lys Lys Leu Val Arg Leu Thr Ile Asp Thr His 
                405                 410                 415     


Ser His His Trp Glu Arg Asp Gln Gln Glu Glu Lys His Gly Pro Arg 
            420                 425                 430         


Arg Arg Phe Ser Pro Val Glu Met Ala Ile Arg Thr Lys Trp Ser Glu 
        435                 440                 445             


Ala Thr Ile Asn Trp Asn Gly Thr Val Pro Phe Phe 
    450                 455                 460 

<210>  1850
<211>  541
<212>  DNA
<213>  Homo sapiens

<400>  1850
ggttggagtg cagtggcgcg atcttggctc actgcaaccg ccacttccca ggttcaagtg     60

gttctcctgc ctcagcctcc tgagtacctg aaattacagg cgcccgccac cacgccagtc    120

tcaatacctt cacagaggtg aagaagcagc aaccaaatga attagacagc aacatgattc    180

ctagagaatg gcaagaccaa ttcttcaact acttcttcag catttctgaa acatatggaa    240

gatggcccat tgtgctctct taattctttg ataatctgga cattgacttt tccattatat    300

gacctgggct tgtgggcatc atgtcataat gcacctgttc agacatctcc ctgtaccaat    360

atggatcact tgaagagact cctttgcccc catcaaaaag gatacagttg tgtatctctt    420

ccatttttgt ttacagtgcc taaaattatt tgagcagttt ttcacctctt ctctgataaa    480

caccttatta gtccttaaaa agaaaagaaa aaaggaaaat aaaactttta ttgagatcct    540

a                                                                    541


<210>  1851
<211>  72
<212>  PRT
<213>  Homo sapiens

<400>  1851


Met Glu Asp Gly Pro Leu Cys Ser Leu Asn Ser Leu Ile Ile Trp Thr 
1               5                   10                  15      


Leu Thr Phe Pro Leu Tyr Asp Leu Gly Leu Trp Ala Ser Cys His Asn 
            20                  25                  30          


Ala Pro Val Gln Thr Ser Pro Cys Thr Asn Met Asp His Leu Lys Arg 
        35                  40                  45              


Leu Leu Cys Pro His Gln Lys Gly Tyr Ser Cys Val Ser Leu Pro Phe 
    50                  55                  60                  


Leu Phe Thr Val Pro Lys Ile Ile 
65                  70          

<210>  1852
<211>  830
<212>  DNA
<213>  Homo sapiens

<400>  1852
gaatagggga aaagttccat gactttttaa aaaatatatg ttatatatgt ttaagacaca     60

ttttatgttt taaaactacc aatagtgaag aattgattct gatcttatta attctgtagt    120

gttgttcatt tattttaaaa atcttatttt tcattttttt cagattgaag ataaaacttt    180

ccaagtcctt ggtaatcttt acagcgaggg agactgcact tacctgaaat gttctgttaa    240

tggagttgct agtaaagcga agctgattat cctggaaaac actatttacc tattttccaa    300

ggaaggaagt attgagattg acattccagt ccccaaatac ttatcttctg tgagctcaca    360

agaaactcag ggcggcccct tagctcctat gactggaacc attgaaaagg tgtttgtcaa    420

agctggagac aaagtgaaag cgggagattc cctcatggtt atgatcgcca tgaagatgga    480

gcataccata aagtctccaa aggatggcac agtaaagaaa gtgttctaca gagaaggtgc    540

tcaggccaac agacacactc ctttagtcga gtttgaggag gaagaatcag acaaaaggga    600

atcggaataa actccagcaa ggaaatggcc agttaagtag tgtcttctct ctccaccaaa    660

aagaggaagt gcctccagct tttctggggg tctcataaag agcagtttta ctaaatgatt    720

gtatgcttat gctgaacacc tttcatattg gagaatcatg catttgggtc actaattatc    780

tcaaaatatt tcatactaat aaagttgaat tattttttat tggaagccaa               830


<210>  1853
<211>  73
<212>  PRT
<213>  Homo sapiens

<400>  1853


Met Thr Gly Thr Ile Glu Lys Val Phe Val Lys Ala Gly Asp Lys Val 
1               5                   10                  15      


Lys Ala Gly Asp Ser Leu Met Val Met Ile Ala Met Lys Met Glu His 
            20                  25                  30          


Thr Ile Lys Ser Pro Lys Asp Gly Thr Val Lys Lys Val Phe Tyr Arg 
        35                  40                  45              


Glu Gly Ala Gln Ala Asn Arg His Thr Pro Leu Val Glu Phe Glu Glu 
    50                  55                  60                  


Glu Glu Ser Asp Lys Arg Glu Ser Glu 
65                  70              

<210>  1854
<211>  2945
<212>  DNA
<213>  Homo sapiens

<400>  1854
ggtaggaaaa ccccaggcac tttcggaggg gttctgccgg cagtcacggc gtcgggagga     60

agacatcccc accagccctt ccctttctcc ccgcttccgc acatccacgc ttcagcgcgc    120

ctttggcttc tgtttttcca tttctgagga ctgggcccgc catcctccag gctcccctcg    180

ccgtcgctgc agctcgtagc cgtttacatc gggctttcgc agcacccctt aggtgggagc    240

gttgttataa tccggttccg gggaagccca aagggatcaa cgacttcctc aacgaaacac    300

agctagtaag aaatggggcc gggatgccct caaagccatt tttcagttca gctgtgcccc    360

atcaggtgtc cagttcagag aaagactcct ggagttcctt ctcattgtta gaagagtgaa    420

gttgtcaaga agagcaaatg taccttccac agagctggga aattattttg tcaaaaactc    480

ttgtacccaa gtttgaacaa cgctatcaga tgactcagtc tagctcacct gactccagct    540

ctgtttcaaa ttttgagctc taagctttgg tggcaataac tctggcagtg aaaaaaccct    600

caggcttgta gatagctttg cttctttgtc ttcttttgct tcatcgttat catccttcat    660

cattctggaa agattgacag tttagtgttc aagggcacag actctgcagt caaggctgag    720

gtcttagtta gctactcact aggtgtgtga ctttgggaca tgggtgtgga ggcaaagaac    780

catgaagtac acaacagcca caggaagaaa cattaccaag gtcctcattg caaacagagg    840

agaaattgcc tgcagggtga tgcgcacagc caaaaaactg ggtgtacaga ctgtggcggt    900

ttatagtgag gctgacagaa attccatgca tgtagatatg gcagatgaag catattccat    960

cggccccgct ccctcccagc agagctacct atctatggag aaaatcattc aagtggccaa   1020

gacctctgct gcacaggcta tccatccagg atgcggtttt ctctcagaaa acatggaatt   1080

tgctgaactt tgtaagcaag aaggaattat ttttataggc cctcctccat ctgcaattag   1140

agacatgggt ataaagagca catccaaatc cataatggct gctgctggag tacctgttgt   1200

ggagggttat catggtgagg accaatcaga ccagtgcctg aaggaacacg ccaggagaat   1260

tggctatcct gtcatgatta aagccgtccg gggtggagga ggaaaaggaa tgaggattgt   1320

tagatcagaa caagaatttc aagaacagtt agagtcagca cggagagaag ctaagaagtc   1380

tttcaatgat gatgctatgc tgatcgagaa gtttgtagac acaccgaggc atgtagaagt   1440

ccaggtgttt ggtgatcacc atggcaatgc tgtgtacttg tttgaaagag actgtagtgt   1500

gcagaggcga catcagaaga tcattgagga ggccccagcg cctggtatta aatctgaagt   1560

aagaaaaaag ctgggagaag ctgcagtcag agctgctaaa gctgtaaatt atgttggagc   1620

agggactgtg gagtttatta tggactcaaa acataatttc tgtttcatgg agatgaatac   1680

aaggctgcaa gtggaacatc ctgttactga gatgatcaca ggaactgact tggtggagtg   1740

gcagcttaga attgcagcag gagagaagat tcctttgagc caggaagaaa taactctgca   1800

gggccatgcc ttcgaagcta gaatatatgc agaagatcct agcaataact tcatgcctgt   1860

ggcaggccca ttagtgcacc tctctactcc tcgagcagac ccttccacca ggattgaaac   1920

tggagtacgg caaggagacg aagtttccgt gcattatgac cccatgattg cgaagctggt   1980

cgtgtgggca gcagatcgcc aggcggcatt gacaaaactg aggtacagcc ttcgtcagta   2040

caatatcaat tctctccatt ttcgtctagc agtggaagaa gactgaatat ctcgtatacc   2100

agaaacatga ctcttaaaga tggtaaaaac agttttcgtc tcctcggata atcaaccatt   2160

tccatactca tgtaatctag gcatactctg gagttattac aggtttggtt ccagaccact   2220

acaataaaat gtagccatag ctgtaacgta taaccatgat gggtcttata gcatgcagat   2280

tgaagataaa actttccaag tccttggtaa tctttacagc gagggagact gcacttacct   2340

gaaatgttct gttaatggag ttgctagtaa agcgaagctg attatcctgg aaaacactat   2400

ttacctattt tccaaggaag gaagtattga gattgacatt ccagtcccca aatacttatc   2460

ttctgtgagc tcacaagaaa ctcagggcgg ccccttagct cctatgactg gaaccattga   2520

aaaggtgttt gtcaaagctg gagacaaagt gaaagcggga gattccctca tggttatgat   2580

cgccatgaag atggagcata ccataaagtc tccaaaggat ggcacagtaa agaaagtgtt   2640

ctacagagaa ggtgctcagg ccaacagaca cactccttta gtcgagtttg aggaggaaga   2700

atcagacaaa agggaatcgg aataaactcc agcaaggaaa tggccagtta agtagtgtct   2760

tctctctcca ccaaaaagag gaagtgcctc cagcttttct gggggtctca taaagagcag   2820

ttttactaaa tgattgtatg cttatgctga acacctttca tattggagaa tcatgcattt   2880

gggtcactaa ttatctcaaa atatttcata ctaataaagt tgaattattt tttattggaa   2940

gccaa                                                               2945


<210>  1855
<211>  434
<212>  PRT
<213>  Homo sapiens

<400>  1855


Met Lys Tyr Thr Thr Ala Thr Gly Arg Asn Ile Thr Lys Val Leu Ile 
1               5                   10                  15      


Ala Asn Arg Gly Glu Ile Ala Cys Arg Val Met Arg Thr Ala Lys Lys 
            20                  25                  30          


Leu Gly Val Gln Thr Val Ala Val Tyr Ser Glu Ala Asp Arg Asn Ser 
        35                  40                  45              


Met His Val Asp Met Ala Asp Glu Ala Tyr Ser Ile Gly Pro Ala Pro 
    50                  55                  60                  


Ser Gln Gln Ser Tyr Leu Ser Met Glu Lys Ile Ile Gln Val Ala Lys 
65                  70                  75                  80  


Thr Ser Ala Ala Gln Ala Ile His Pro Gly Cys Gly Phe Leu Ser Glu 
                85                  90                  95      


Asn Met Glu Phe Ala Glu Leu Cys Lys Gln Glu Gly Ile Ile Phe Ile 
            100                 105                 110         


Gly Pro Pro Pro Ser Ala Ile Arg Asp Met Gly Ile Lys Ser Thr Ser 
        115                 120                 125             


Lys Ser Ile Met Ala Ala Ala Gly Val Pro Val Val Glu Gly Tyr His 
    130                 135                 140                 


Gly Glu Asp Gln Ser Asp Gln Cys Leu Lys Glu His Ala Arg Arg Ile 
145                 150                 155                 160 


Gly Tyr Pro Val Met Ile Lys Ala Val Arg Gly Gly Gly Gly Lys Gly 
                165                 170                 175     


Met Arg Ile Val Arg Ser Glu Gln Glu Phe Gln Glu Gln Leu Glu Ser 
            180                 185                 190         


Ala Arg Arg Glu Ala Lys Lys Ser Phe Asn Asp Asp Ala Met Leu Ile 
        195                 200                 205             


Glu Lys Phe Val Asp Thr Pro Arg His Val Glu Val Gln Val Phe Gly 
    210                 215                 220                 


Asp His His Gly Asn Ala Val Tyr Leu Phe Glu Arg Asp Cys Ser Val 
225                 230                 235                 240 


Gln Arg Arg His Gln Lys Ile Ile Glu Glu Ala Pro Ala Pro Gly Ile 
                245                 250                 255     


Lys Ser Glu Val Arg Lys Lys Leu Gly Glu Ala Ala Val Arg Ala Ala 
            260                 265                 270         


Lys Ala Val Asn Tyr Val Gly Ala Gly Thr Val Glu Phe Ile Met Asp 
        275                 280                 285             


Ser Lys His Asn Phe Cys Phe Met Glu Met Asn Thr Arg Leu Gln Val 
    290                 295                 300                 


Glu His Pro Val Thr Glu Met Ile Thr Gly Thr Asp Leu Val Glu Trp 
305                 310                 315                 320 


Gln Leu Arg Ile Ala Ala Gly Glu Lys Ile Pro Leu Ser Gln Glu Glu 
                325                 330                 335     


Ile Thr Leu Gln Gly His Ala Phe Glu Ala Arg Ile Tyr Ala Glu Asp 
            340                 345                 350         


Pro Ser Asn Asn Phe Met Pro Val Ala Gly Pro Leu Val His Leu Ser 
        355                 360                 365             


Thr Pro Arg Ala Asp Pro Ser Thr Arg Ile Glu Thr Gly Val Arg Gln 
    370                 375                 380                 


Gly Asp Glu Val Ser Val His Tyr Asp Pro Met Ile Ala Lys Leu Val 
385                 390                 395                 400 


Val Trp Ala Ala Asp Arg Gln Ala Ala Leu Thr Lys Leu Arg Tyr Ser 
                405                 410                 415     


Leu Arg Gln Tyr Asn Ile Asn Ser Leu His Phe Arg Leu Ala Val Glu 
            420                 425                 430         


Glu Asp 
        

<210>  1856
<211>  2229
<212>  DNA
<213>  Homo sapiens

<400>  1856
acgaggcttc gtagtggagg aacgggtttg gcgtgtggga cgcagctgcc tctgtactgg     60

ggagtcacgg agtggccggg ctccagggac atggcggcgg cctctgcggt gtcggtgctg    120

ctggtggcgg cggagaggaa ccggtggcat cgtctcccga gcctgctcct gccgccgagg    180

acatgggtgt ggaggcaaag aaccatgaag tacacaacag ccacaggcag atgaagcata    240

ttccatcggc cccgctccct cccagcagag ctacctatct atggagaaaa tcattcaagt    300

ggccaagacc tctgctgcac agcacatcca aatccataat ggctgctgct ggagtacctg    360

ttgtggaggg ttatcatggt gaggaccaat cagaccagtg cctgaaggaa cacgccagga    420

gaattggcta tcctgtcatg attaaagccg tccggggtgg aggaggaaaa ggaatgagga    480

ttgttagatc agaacaagaa tttcaagaac agttagagtc agcacggaga gaagctaaga    540

agtctttcaa tgatgatgct atgctgatcg agaagtttgt agacacaccg aggcatgtag    600

aagtccaggt gtttggtgat caccatggca atgctgtgta cttgtttgaa agagactgta    660

gtgtgcagag gcgacatcag aagatcattg aggaggcccc agcgcctggt attaaatctg    720

aagtaagaaa aaagctggga gaagctgcag tcagagctgc taaagctgta aattatgttg    780

gagcagggac tgtggagttt attatggact caaaacataa tttctgtttc atggagatga    840

atacaaggct gcaagtggaa catcctgtta ctgagatgat cacaggaact gacttggtgg    900

agtggcagct tagaattgca gcaggagaga agattccttt gagccaggaa gaaataactc    960

tgcagggcca tgccttcgaa gctagaatat atgcagaaga tcctagcaat aacttcatgc   1020

ctgtggcagg cccattagtg cacctctcta ctcctcgagc agacccttcc accaggattg   1080

aaactggagt acggcaagga gacgaagttt ccgtgcatta tgaccccatg attgcgaagc   1140

tggtcgtgtg ggcagcagat cgccaggcgg cattgacaaa actgaggtac agccttcgtc   1200

agtacaatat tgttggactg cacaccaaca ttgacttctt actcaacctg tctggccacc   1260

cagagtttga agctgggaac gtgcacactg atttcatccc tcaacaccac aaacagttgt   1320

tgctcagtcg gaaggctgca gccaaagagt ctttatgcca ggcagccctg ggtctcatcc   1380

tcaaggagaa agccatgacc gacactttca ctcttcaggc acatgatcaa ttctctccat   1440

tttcgtctag cagtggaaga agactgaata tctcgtatac cagaaacatg actcttaaag   1500

atggtaaaaa caatgtagcc atagctgtaa cgtataacca tgatgggtct tatagcatgc   1560

agattgaaga taaaactttc caagtccttg gtaatcttta cagcgaggga gactgcactt   1620

acctgaaatg ttctgttaat ggagttgcta gtaaagcgaa gctgattatc ctggaaaaca   1680

ctatttacct attttccaag gaaggaagta ttgagattga cattccagtc cccaaatact   1740

tatcttctgt gagctcacaa gaaactcagg gcggcccctt agctcctatg actggaacca   1800

ttgaaaaggt gtttgtcaaa gctggagaca aagtgaaagc gggagattcc ctcatggtta   1860

tgatcgccat gaagatggag cataccataa agtctccaaa ggatggcaca gtaaagaaag   1920

tgttctacag agaaggtgct caggccaaca gacacactcc tttagtcgag tttgaggagg   1980

aagaatcaga caaaagggaa tcggaataaa ctccagcaag gaaatggcca gttaagtagt   2040

gtcttctctc tccaccaaaa agaggaagtg cctccagctt ttctgggggt ctcataaaga   2100

gcagttttac taaatgattg tatgcttatg ctgaacacct ttcatattgg agaatcatgc   2160

atttgggtca ctaattatct caaaatattt catactaata aagttgaatt attttttatt   2220

ggaagccaa                                                           2229


<210>  1857
<211>  608
<212>  PRT
<213>  Homo sapiens

<400>  1857


Met Gly Val Glu Ala Lys Asn His Glu Val His Asn Ser His Arg Gln 
1               5                   10                  15      


Met Lys His Ile Pro Ser Ala Pro Leu Pro Pro Ser Arg Ala Thr Tyr 
            20                  25                  30          


Leu Trp Arg Lys Ser Phe Lys Trp Pro Arg Pro Leu Leu His Ser Thr 
        35                  40                  45              


Ser Lys Ser Ile Met Ala Ala Ala Gly Val Pro Val Val Glu Gly Tyr 
    50                  55                  60                  


His Gly Glu Asp Gln Ser Asp Gln Cys Leu Lys Glu His Ala Arg Arg 
65                  70                  75                  80  


Ile Gly Tyr Pro Val Met Ile Lys Ala Val Arg Gly Gly Gly Gly Lys 
                85                  90                  95      


Gly Met Arg Ile Val Arg Ser Glu Gln Glu Phe Gln Glu Gln Leu Glu 
            100                 105                 110         


Ser Ala Arg Arg Glu Ala Lys Lys Ser Phe Asn Asp Asp Ala Met Leu 
        115                 120                 125             


Ile Glu Lys Phe Val Asp Thr Pro Arg His Val Glu Val Gln Val Phe 
    130                 135                 140                 


Gly Asp His His Gly Asn Ala Val Tyr Leu Phe Glu Arg Asp Cys Ser 
145                 150                 155                 160 


Val Gln Arg Arg His Gln Lys Ile Ile Glu Glu Ala Pro Ala Pro Gly 
                165                 170                 175     


Ile Lys Ser Glu Val Arg Lys Lys Leu Gly Glu Ala Ala Val Arg Ala 
            180                 185                 190         


Ala Lys Ala Val Asn Tyr Val Gly Ala Gly Thr Val Glu Phe Ile Met 
        195                 200                 205             


Asp Ser Lys His Asn Phe Cys Phe Met Glu Met Asn Thr Arg Leu Gln 
    210                 215                 220                 


Val Glu His Pro Val Thr Glu Met Ile Thr Gly Thr Asp Leu Val Glu 
225                 230                 235                 240 


Trp Gln Leu Arg Ile Ala Ala Gly Glu Lys Ile Pro Leu Ser Gln Glu 
                245                 250                 255     


Glu Ile Thr Leu Gln Gly His Ala Phe Glu Ala Arg Ile Tyr Ala Glu 
            260                 265                 270         


Asp Pro Ser Asn Asn Phe Met Pro Val Ala Gly Pro Leu Val His Leu 
        275                 280                 285             


Ser Thr Pro Arg Ala Asp Pro Ser Thr Arg Ile Glu Thr Gly Val Arg 
    290                 295                 300                 


Gln Gly Asp Glu Val Ser Val His Tyr Asp Pro Met Ile Ala Lys Leu 
305                 310                 315                 320 


Val Val Trp Ala Ala Asp Arg Gln Ala Ala Leu Thr Lys Leu Arg Tyr 
                325                 330                 335     


Ser Leu Arg Gln Tyr Asn Ile Val Gly Leu His Thr Asn Ile Asp Phe 
            340                 345                 350         


Leu Leu Asn Leu Ser Gly His Pro Glu Phe Glu Ala Gly Asn Val His 
        355                 360                 365             


Thr Asp Phe Ile Pro Gln His His Lys Gln Leu Leu Leu Ser Arg Lys 
    370                 375                 380                 


Ala Ala Ala Lys Glu Ser Leu Cys Gln Ala Ala Leu Gly Leu Ile Leu 
385                 390                 395                 400 


Lys Glu Lys Ala Met Thr Asp Thr Phe Thr Leu Gln Ala His Asp Gln 
                405                 410                 415     


Phe Ser Pro Phe Ser Ser Ser Ser Gly Arg Arg Leu Asn Ile Ser Tyr 
            420                 425                 430         


Thr Arg Asn Met Thr Leu Lys Asp Gly Lys Asn Asn Val Ala Ile Ala 
        435                 440                 445             


Val Thr Tyr Asn His Asp Gly Ser Tyr Ser Met Gln Ile Glu Asp Lys 
    450                 455                 460                 


Thr Phe Gln Val Leu Gly Asn Leu Tyr Ser Glu Gly Asp Cys Thr Tyr 
465                 470                 475                 480 


Leu Lys Cys Ser Val Asn Gly Val Ala Ser Lys Ala Lys Leu Ile Ile 
                485                 490                 495     


Leu Glu Asn Thr Ile Tyr Leu Phe Ser Lys Glu Gly Ser Ile Glu Ile 
            500                 505                 510         


Asp Ile Pro Val Pro Lys Tyr Leu Ser Ser Val Ser Ser Gln Glu Thr 
        515                 520                 525             


Gln Gly Gly Pro Leu Ala Pro Met Thr Gly Thr Ile Glu Lys Val Phe 
    530                 535                 540                 


Val Lys Ala Gly Asp Lys Val Lys Ala Gly Asp Ser Leu Met Val Met 
545                 550                 555                 560 


Ile Ala Met Lys Met Glu His Thr Ile Lys Ser Pro Lys Asp Gly Thr 
                565                 570                 575     


Val Lys Lys Val Phe Tyr Arg Glu Gly Ala Gln Ala Asn Arg His Thr 
            580                 585                 590         


Pro Leu Val Glu Phe Glu Glu Glu Glu Ser Asp Lys Arg Glu Ser Glu 
        595                 600                 605             

<210>  1858
<211>  2545
<212>  DNA
<213>  Homo sapiens

<400>  1858
acattcttgg atcagcccaa aggtaggctc aggctccgac ggtggccggc gggggtcacg     60

aggcttcgta gtggaggaac gggtttggcg tgtgggacgc agctgcctct gtactgggga    120

gtcacggagt ggccgggctc cagggacatg gcggcggcct ctgcggtgtc ggtgctgctg    180

gtggcggcgg agaggaaccg gtggcatcgt ctcccgagcc tgctcctgcc gccgaggaca    240

tgggtgtgga ggcaaagaac catgaagtac acaacagcca caggaagaaa cattaccaag    300

gtcctcattg caaacagagg agaaattgcc tgcagggtga tgcgcacagc caaaaaactg    360

ggtgtacaga ctgtggcggt ttatagtgag gctgacagaa attccatgca tgtagatatg    420

gcagatgaag catattccat cggccccgct ccctcccagc agagctacct atctatggag    480

aaaatcattc aagtggccaa gacctctgct gcacaggcta tccatccagg atgcggtttt    540

ctctcagaaa acatggaatt tgctgaactt tgtaagcaag aaggaattat ttttataggc    600

cctcctccat ctgcaattag agacatgggt ataaagagca catccaaatc cataatggct    660

gctgctggag tacctgttgt ggagggttat catggtgagg accaatcaga ccagtgcctg    720

aaggaacacg ccaggagaat tggctatcct gtcatgatta aagccgtccg gggtggagga    780

ggaaaaggaa tgaggattgt tagatcagaa caagaatttc aagaacagtt agagtcagca    840

cggagagaag ctaagaagtc tttcaatgat gatgctatgc tgatcgagaa gtttgtagac    900

acaccgaggc atgtagaagt ccaggtgttt ggtgatcacc atggcaatgc tgtgtacttg    960

tttgaaagag actgtagtgt gcagaggcga catcagaaga tcattgagga ggccccagcg   1020

cctggtatta aatctgaagt aagaaaaaag ctgggagaag ctgcagtcag agctgctaaa   1080

gctgtaaatt atgttggagc agggactgtg gagtttatta tggactcaaa acataatttc   1140

tgtttcatgg agatgaatac aaggctgcaa gtggaacatc ctgttactga gatgatcaca   1200

ggaactgact tggtggagtg gcagcttaga attgcagcag gagagaagat tcctttgagc   1260

caggaagaaa taactctgca gggccatgcc ttcgaagcta gaatatatgc agaagatcct   1320

agcaataact tcatgcctgt ggcaggccca ttagtgcacc tctctactcc tcgagcagac   1380

ccttccacca ggattgaaac tggagtacgg caaggagacg aagtttccgt gcattatgac   1440

cccatgattg cgaagctggt cgtgtgggca gcagatcgcc aggcggcatt gacaaaactg   1500

aggtacagcc ttcgtcagta caatattgtt ggactgcaca ccaacattga cttcttactc   1560

aacctgtctg gccacccaga gtttgaagct gggaacgtgc acactgattt catccctcaa   1620

caccacaaac agttgttgct cagtcggaag gctgcagcca aagagtcttt atgccaggca   1680

gccctgggtc tcatcctcaa ggagaaagcc atgaccgaca ctttcactct tcaggcacat   1740

gatcaattct ctccattttc gtctagcagt ggaagaagac tgaatatctc gtataccaga   1800

aacatgactc ttaaagatgg taaaaacaat gtagccatag ctgtaacgta taaccatgat   1860

gggtcttata gcatgcagat tgaagataaa actttccaag tccttggtaa tctttacagc   1920

gagggagact gcacttacct gaaatgttct gttaatggag ttgctagtaa agcgaagctg   1980

attatcctgg aaaacactat ttacctattt tccaaggaag gaagtattga gattgacatt   2040

ccagtcccca aatacttatc ttctgtgagc tcacaagaaa ctcagggcgg ccccttagct   2100

cctatgactg gaaccattga aaaggtgttt gtcaaagctg gagacaaagt gaaagcggga   2160

gattccctca tggttatgat cgccatgaag atggagcata ccataaagtc tccaaaggat   2220

ggcacagtaa agaaagtgtt ctacagagaa ggtgctcagg ccaacagaca cactccttta   2280

gtcgagtttg aggaggaaga atcagacaaa agggaatcgg aataaactcc agcaaggaaa   2340

tggccagtta agtagtgtct tctctctcca ccaaaaagag gaagtgcctc cagcttttct   2400

gggggtctca taaagagcag ttttactaaa tgattgtatg cttatgctga acacctttca   2460

tattggagaa tcatgcattt gggtcactaa ttatctcaaa atatttcata ctaataaagt   2520

tgaattattt tttattggaa gccaa                                         2545


<210>  1859
<211>  725
<212>  PRT
<213>  Homo sapiens

<400>  1859


Met Ala Ala Ala Ser Ala Val Ser Val Leu Leu Val Ala Ala Glu Arg 
1               5                   10                  15      


Asn Arg Trp His Arg Leu Pro Ser Leu Leu Leu Pro Pro Arg Thr Trp 
            20                  25                  30          


Val Trp Arg Gln Arg Thr Met Lys Tyr Thr Thr Ala Thr Gly Arg Asn 
        35                  40                  45              


Ile Thr Lys Val Leu Ile Ala Asn Arg Gly Glu Ile Ala Cys Arg Val 
    50                  55                  60                  


Met Arg Thr Ala Lys Lys Leu Gly Val Gln Thr Val Ala Val Tyr Ser 
65                  70                  75                  80  


Glu Ala Asp Arg Asn Ser Met His Val Asp Met Ala Asp Glu Ala Tyr 
                85                  90                  95      


Ser Ile Gly Pro Ala Pro Ser Gln Gln Ser Tyr Leu Ser Met Glu Lys 
            100                 105                 110         


Ile Ile Gln Val Ala Lys Thr Ser Ala Ala Gln Ala Ile His Pro Gly 
        115                 120                 125             


Cys Gly Phe Leu Ser Glu Asn Met Glu Phe Ala Glu Leu Cys Lys Gln 
    130                 135                 140                 


Glu Gly Ile Ile Phe Ile Gly Pro Pro Pro Ser Ala Ile Arg Asp Met 
145                 150                 155                 160 


Gly Ile Lys Ser Thr Ser Lys Ser Ile Met Ala Ala Ala Gly Val Pro 
                165                 170                 175     


Val Val Glu Gly Tyr His Gly Glu Asp Gln Ser Asp Gln Cys Leu Lys 
            180                 185                 190         


Glu His Ala Arg Arg Ile Gly Tyr Pro Val Met Ile Lys Ala Val Arg 
        195                 200                 205             


Gly Gly Gly Gly Lys Gly Met Arg Ile Val Arg Ser Glu Gln Glu Phe 
    210                 215                 220                 


Gln Glu Gln Leu Glu Ser Ala Arg Arg Glu Ala Lys Lys Ser Phe Asn 
225                 230                 235                 240 


Asp Asp Ala Met Leu Ile Glu Lys Phe Val Asp Thr Pro Arg His Val 
                245                 250                 255     


Glu Val Gln Val Phe Gly Asp His His Gly Asn Ala Val Tyr Leu Phe 
            260                 265                 270         


Glu Arg Asp Cys Ser Val Gln Arg Arg His Gln Lys Ile Ile Glu Glu 
        275                 280                 285             


Ala Pro Ala Pro Gly Ile Lys Ser Glu Val Arg Lys Lys Leu Gly Glu 
    290                 295                 300                 


Ala Ala Val Arg Ala Ala Lys Ala Val Asn Tyr Val Gly Ala Gly Thr 
305                 310                 315                 320 


Val Glu Phe Ile Met Asp Ser Lys His Asn Phe Cys Phe Met Glu Met 
                325                 330                 335     


Asn Thr Arg Leu Gln Val Glu His Pro Val Thr Glu Met Ile Thr Gly 
            340                 345                 350         


Thr Asp Leu Val Glu Trp Gln Leu Arg Ile Ala Ala Gly Glu Lys Ile 
        355                 360                 365             


Pro Leu Ser Gln Glu Glu Ile Thr Leu Gln Gly His Ala Phe Glu Ala 
    370                 375                 380                 


Arg Ile Tyr Ala Glu Asp Pro Ser Asn Asn Phe Met Pro Val Ala Gly 
385                 390                 395                 400 


Pro Leu Val His Leu Ser Thr Pro Arg Ala Asp Pro Ser Thr Arg Ile 
                405                 410                 415     


Glu Thr Gly Val Arg Gln Gly Asp Glu Val Ser Val His Tyr Asp Pro 
            420                 425                 430         


Met Ile Ala Lys Leu Val Val Trp Ala Ala Asp Arg Gln Ala Ala Leu 
        435                 440                 445             


Thr Lys Leu Arg Tyr Ser Leu Arg Gln Tyr Asn Ile Val Gly Leu His 
    450                 455                 460                 


Thr Asn Ile Asp Phe Leu Leu Asn Leu Ser Gly His Pro Glu Phe Glu 
465                 470                 475                 480 


Ala Gly Asn Val His Thr Asp Phe Ile Pro Gln His His Lys Gln Leu 
                485                 490                 495     


Leu Leu Ser Arg Lys Ala Ala Ala Lys Glu Ser Leu Cys Gln Ala Ala 
            500                 505                 510         


Leu Gly Leu Ile Leu Lys Glu Lys Ala Met Thr Asp Thr Phe Thr Leu 
        515                 520                 525             


Gln Ala His Asp Gln Phe Ser Pro Phe Ser Ser Ser Ser Gly Arg Arg 
    530                 535                 540                 


Leu Asn Ile Ser Tyr Thr Arg Asn Met Thr Leu Lys Asp Gly Lys Asn 
545                 550                 555                 560 


Asn Val Ala Ile Ala Val Thr Tyr Asn His Asp Gly Ser Tyr Ser Met 
                565                 570                 575     


Gln Ile Glu Asp Lys Thr Phe Gln Val Leu Gly Asn Leu Tyr Ser Glu 
            580                 585                 590         


Gly Asp Cys Thr Tyr Leu Lys Cys Ser Val Asn Gly Val Ala Ser Lys 
        595                 600                 605             


Ala Lys Leu Ile Ile Leu Glu Asn Thr Ile Tyr Leu Phe Ser Lys Glu 
    610                 615                 620                 


Gly Ser Ile Glu Ile Asp Ile Pro Val Pro Lys Tyr Leu Ser Ser Val 
625                 630                 635                 640 


Ser Ser Gln Glu Thr Gln Gly Gly Pro Leu Ala Pro Met Thr Gly Thr 
                645                 650                 655     


Ile Glu Lys Val Phe Val Lys Ala Gly Asp Lys Val Lys Ala Gly Asp 
            660                 665                 670         


Ser Leu Met Val Met Ile Ala Met Lys Met Glu His Thr Ile Lys Ser 
        675                 680                 685             


Pro Lys Asp Gly Thr Val Lys Lys Val Phe Tyr Arg Glu Gly Ala Gln 
    690                 695                 700                 


Ala Asn Arg His Thr Pro Leu Val Glu Phe Glu Glu Glu Glu Ser Asp 
705                 710                 715                 720 


Lys Arg Glu Ser Glu 
                725 

<210>  1860
<211>  2767
<212>  DNA
<213>  Homo sapiens

<400>  1860
tctgagggtt tcctaggggt tttgctgggt tctttctagc ttaatttaaa aaaaacccta     60

cttgaggggg ctcttcagca actgcttgct cgagcccact cccactctgt gaccgtcttc    120

aataaatctg tgcccactcc gtggtgttgt gttcaactat ttgtccaata cgccaagaac    180

ctggacatca catttaggac tttttttttt taatttgaga tggagttttg ctcttgtcac    240

tcaggctgga gtgcagtggc gtgatctcgg ctcactgcaa cttccgcctc ccgggttcaa    300

gcgattcttc cacctcagcc tcccgagtag ctgggattac aggcgcccaa caccatgccc    360

agctaatttt tgtattttta gtagagatgg agtttcacca tgttggccag gctggtctcc    420

aactcctgac ctcagatgat ccacccacct cagcctccca aagtgctggg attacgggcg    480

tgggccaccg cacctggcag catttaggac cttctctctg gtaacataag taggggaaga    540

gacaacacac acccaaaatg gcaagaatcc gctggcacgg acaggctgga cccaggacat    600

gggtgtggag gcaaagaacc atgaagtaca caacagccac aggcagatga agcatattcc    660

atcggccccg ctccctccca gcagagctac ctatctatgg agaaaatcat tcaagtggcc    720

aagacctctg ctgcacaggc tatccatcca ggatgcggtt ttctctcaga aaacatggaa    780

tttgctgaac tttgtaagca agaaggaatt atttttatag gccctcctcc atctgcaatt    840

agagacatgg gtataaagag cacatccaaa tccataatgg ctgctgctgg agtacctgtt    900

gtggagggtt atcatggtga ggaccaatca gaccagtgcc tgaaggaaca cgccaggaga    960

attggctatc ctgtcatgat taaagccgtc cggggtggag gaggaaaagg aatgaggatt   1020

gttagatcag aacaagaatt tcaagaacag ttagagtcag cacggagaga agctaagaag   1080

tctttcaatg atgatgctat gctgatcgag aagtttgtag acacaccgag gcatgtagaa   1140

gtccaggtgt ttggtgatca ccatggcaat gctgtgtact tgtttgaaag agactgtagt   1200

gtgcagaggc gacatcagaa gatcattgag gaggccccag cgcctggtat taaatctgaa   1260

gtaagaaaaa agctgggaga agctgcagtc agagctgcta aagctgtaaa ttatgttgga   1320

gcagggactg tggagtttat tatggactca aaacataatt tctgtttcat ggagatgaat   1380

acaaggctgc aagtggaaca tcctgttact gagatgatca caggaactga cttggtggag   1440

tggcagctta gaattgcagc aggagagaag attcctttga gccaggaaga aataactctg   1500

cagggccatg ccttcgaagc tagaatatat gcagaagatc ctagcaataa cttcatgcct   1560

gtggcaggcc cattagtgca cctctctact cctcgagcag acccttccac caggattgaa   1620

actggagtac ggcaaggaga cgaagtttcc gtgcattatg accccatgat tgcgaagctg   1680

gtcgtgtggg cagcagatcg ccaggcggca ttgacaaaac tgaggtacag ccttcgtcag   1740

tacaatattg ttggactgca caccaacatt gacttcttac tcaacctgtc tggccaccca   1800

gagtttgaag ctgggaacgt gcacactgat ttcatccctc aacaccacaa acagttgttg   1860

ctcagtcgga aggctgcagc caaagagtct ttatgccagg cagccctggg tctcatcctc   1920

aaggagaaag ccatgaccga cactttcact cttcaggcac atgatcaatt ctctccattt   1980

tcgtctagca gtggaagaag actgaatatc tcgtatacca gaaacatgac tcttaaagat   2040

ggtaaaaaca atgtagccat agctgtaacg tataaccatg atgggtctta tagcatgcag   2100

attgaagata aaactttcca agtccttggt aatctttaca gcgagggaga ctgcacttac   2160

ctgaaatgtt ctgttaatgg agttgctagt aaagcgaagc tgattatcct ggaaaacact   2220

atttacctat tttccaagga aggaagtatt gagattgaca ttccagtccc caaatactta   2280

tcttctgtga gctcacaaga aactcagggc ggccccttag ctcctatgac tggaaccatt   2340

gaaaaggtgt ttgtcaaagc tggagacaaa gtgaaagcgg gagattccct catggttatg   2400

atcgccatga agatggagca taccataaag tctccaaagg atggcacagt aaagaaagtg   2460

ttctacagag aaggtgctca ggccaacaga cacactcctt tagtcgagtt tgaggaggaa   2520

gaatcagaca aaagggaatc ggaataaact ccagcaagga aatggccagt taagtagtgt   2580

cttctctctc caccaaaaag aggaagtgcc tccagctttt ctgggggtct cataaagagc   2640

agttttacta aatgattgta tgcttatgct gaacaccttt catattggag aatcatgcat   2700

ttgggtcact aattatctca aaatatttca tactaataaa gttgaattat tttttattgg   2760

aagccaa                                                             2767


<210>  1861
<211>  616
<212>  PRT
<213>  Homo sapiens

<400>  1861


Met Glu Lys Ile Ile Gln Val Ala Lys Thr Ser Ala Ala Gln Ala Ile 
1               5                   10                  15      


His Pro Gly Cys Gly Phe Leu Ser Glu Asn Met Glu Phe Ala Glu Leu 
            20                  25                  30          


Cys Lys Gln Glu Gly Ile Ile Phe Ile Gly Pro Pro Pro Ser Ala Ile 
        35                  40                  45              


Arg Asp Met Gly Ile Lys Ser Thr Ser Lys Ser Ile Met Ala Ala Ala 
    50                  55                  60                  


Gly Val Pro Val Val Glu Gly Tyr His Gly Glu Asp Gln Ser Asp Gln 
65                  70                  75                  80  


Cys Leu Lys Glu His Ala Arg Arg Ile Gly Tyr Pro Val Met Ile Lys 
                85                  90                  95      


Ala Val Arg Gly Gly Gly Gly Lys Gly Met Arg Ile Val Arg Ser Glu 
            100                 105                 110         


Gln Glu Phe Gln Glu Gln Leu Glu Ser Ala Arg Arg Glu Ala Lys Lys 
        115                 120                 125             


Ser Phe Asn Asp Asp Ala Met Leu Ile Glu Lys Phe Val Asp Thr Pro 
    130                 135                 140                 


Arg His Val Glu Val Gln Val Phe Gly Asp His His Gly Asn Ala Val 
145                 150                 155                 160 


Tyr Leu Phe Glu Arg Asp Cys Ser Val Gln Arg Arg His Gln Lys Ile 
                165                 170                 175     


Ile Glu Glu Ala Pro Ala Pro Gly Ile Lys Ser Glu Val Arg Lys Lys 
            180                 185                 190         


Leu Gly Glu Ala Ala Val Arg Ala Ala Lys Ala Val Asn Tyr Val Gly 
        195                 200                 205             


Ala Gly Thr Val Glu Phe Ile Met Asp Ser Lys His Asn Phe Cys Phe 
    210                 215                 220                 


Met Glu Met Asn Thr Arg Leu Gln Val Glu His Pro Val Thr Glu Met 
225                 230                 235                 240 


Ile Thr Gly Thr Asp Leu Val Glu Trp Gln Leu Arg Ile Ala Ala Gly 
                245                 250                 255     


Glu Lys Ile Pro Leu Ser Gln Glu Glu Ile Thr Leu Gln Gly His Ala 
            260                 265                 270         


Phe Glu Ala Arg Ile Tyr Ala Glu Asp Pro Ser Asn Asn Phe Met Pro 
        275                 280                 285             


Val Ala Gly Pro Leu Val His Leu Ser Thr Pro Arg Ala Asp Pro Ser 
    290                 295                 300                 


Thr Arg Ile Glu Thr Gly Val Arg Gln Gly Asp Glu Val Ser Val His 
305                 310                 315                 320 


Tyr Asp Pro Met Ile Ala Lys Leu Val Val Trp Ala Ala Asp Arg Gln 
                325                 330                 335     


Ala Ala Leu Thr Lys Leu Arg Tyr Ser Leu Arg Gln Tyr Asn Ile Val 
            340                 345                 350         


Gly Leu His Thr Asn Ile Asp Phe Leu Leu Asn Leu Ser Gly His Pro 
        355                 360                 365             


Glu Phe Glu Ala Gly Asn Val His Thr Asp Phe Ile Pro Gln His His 
    370                 375                 380                 


Lys Gln Leu Leu Leu Ser Arg Lys Ala Ala Ala Lys Glu Ser Leu Cys 
385                 390                 395                 400 


Gln Ala Ala Leu Gly Leu Ile Leu Lys Glu Lys Ala Met Thr Asp Thr 
                405                 410                 415     


Phe Thr Leu Gln Ala His Asp Gln Phe Ser Pro Phe Ser Ser Ser Ser 
            420                 425                 430         


Gly Arg Arg Leu Asn Ile Ser Tyr Thr Arg Asn Met Thr Leu Lys Asp 
        435                 440                 445             


Gly Lys Asn Asn Val Ala Ile Ala Val Thr Tyr Asn His Asp Gly Ser 
    450                 455                 460                 


Tyr Ser Met Gln Ile Glu Asp Lys Thr Phe Gln Val Leu Gly Asn Leu 
465                 470                 475                 480 


Tyr Ser Glu Gly Asp Cys Thr Tyr Leu Lys Cys Ser Val Asn Gly Val 
                485                 490                 495     


Ala Ser Lys Ala Lys Leu Ile Ile Leu Glu Asn Thr Ile Tyr Leu Phe 
            500                 505                 510         


Ser Lys Glu Gly Ser Ile Glu Ile Asp Ile Pro Val Pro Lys Tyr Leu 
        515                 520                 525             


Ser Ser Val Ser Ser Gln Glu Thr Gln Gly Gly Pro Leu Ala Pro Met 
    530                 535                 540                 


Thr Gly Thr Ile Glu Lys Val Phe Val Lys Ala Gly Asp Lys Val Lys 
545                 550                 555                 560 


Ala Gly Asp Ser Leu Met Val Met Ile Ala Met Lys Met Glu His Thr 
                565                 570                 575     


Ile Lys Ser Pro Lys Asp Gly Thr Val Lys Lys Val Phe Tyr Arg Glu 
            580                 585                 590         


Gly Ala Gln Ala Asn Arg His Thr Pro Leu Val Glu Phe Glu Glu Glu 
        595                 600                 605             


Glu Ser Asp Lys Arg Glu Ser Glu 
    610                 615     

<210>  1862
<211>  1344
<212>  DNA
<213>  Homo sapiens

<400>  1862
gtgcatttga cctgtaggcc tctgatttga ccagtacatt tgggctgtag gcctctgatt     60

tgaccagtgc atttgacctg taggcctctg atttgaccag tgcatttggg ctgtaggcct    120

ctgatttgac cagtgcattt gacctgtagg cctctgattt gaccagtaca tttgggctgt    180

aggcctctga tttgaccagt acatttgacc tgtaggcctc tgatttgacc agtgcatttg    240

ggctgtaggc ctctgatttg accagtgcat ttgacctgta ggcctctgat ttgaccagtg    300

catttgggct gtaggcctct gatttgacca gtgcatttgg gctgtaggcc tctgatttga    360

ccagtgcatt tgacctgtag gcctcttatt tgacgagtac atttgggctg taggcctctg    420

atttgaccag tgcatttggg ctgtaggcct ctgatttgac cagtgcattt gacctgtagg    480

cctctgattt gaccagtgca tttgggctgt aggcctctga tttgaccagt gcatttgacc    540

tgtaggcctc tgatttgacc agtacatttg ggctgtaggc ctctgatttg accagtacat    600

ttgacctgta ggcctctgat ttgaccagtg catttgggct gtaggcctct gatttgacca    660

gtacatttgg gctgtaggcc tctgatttga ccagtacatt tgggctgtag gcctctgatt    720

tgaccagtac atttgggctg taggtctcag atttgacctg tacatttggg ctgtaagcct    780

ctgatttgac cagtgcattt gactgtaggc ctctgatttg accagtgcat ttggcagatg    840

gcacaaccac atgggctcta cttctgctct gtaagtttat ataccaaatc tgtggaccac    900

aaaggacctc tgtgttgttt tttttctttt tatttatgtt ttattgttta tattcatggt    960

ttgcaacatg atgttatgag tatatataga cagtaaaatg gttactataa tgaagcagat   1020

gaacatatct aggacctctg tgttttcaaa tattaacctg tcacactgaa tctcaaggtg   1080

tttgtcaaag ctggagacaa agtgaaagcg ggagattccc tcatggttat gatcgccatg   1140

aagatggagg taaggaaatc atgagttcat ttgctatgag gactttggga gcaatcatac   1200

ctaatggttc ttttgcctta ttttgtaagt taataccacc ttaaatatga aaagccatga   1260

ttgacgaagc attaattgta ggaaacaaaa ccaaactatc cttcttgtag aaaagagttt   1320

tactttaact ttgtgaaatt gcac                                          1344


<210>  1863
<211>  52
<212>  PRT
<213>  Homo sapiens

<400>  1863


Met Ala Gln Pro His Gly Leu Tyr Phe Cys Ser Val Ser Leu Tyr Thr 
1               5                   10                  15      


Lys Ser Val Asp His Lys Gly Pro Leu Cys Cys Phe Phe Ser Phe Tyr 
            20                  25                  30          


Leu Cys Phe Ile Val Tyr Ile His Gly Leu Gln His Asp Val Met Ser 
        35                  40                  45              


Ile Tyr Arg Gln 
    50          

<210>  1864
<211>  636
<212>  DNA
<213>  Homo sapiens

<400>  1864
gacggtggcc ggcgggggtc acgaggcttc gtagtggagg aacgggtttg gcgtgtggga     60

cgcagctgcc tctgtactgg ggagtcacgg agtggccggg ctccagggac atggcggcgg    120

cctctgcggt gtcggtgctg ctggtggcgg cggagaggaa ccggtggcat cgtctcccga    180

gcctgctcct gccgccgagg acatgggtgt ggaggcaaag aaccatgaag tacacaacag    240

ccacaggaag aaacattacc aaggtcctca ttgcaaacag aggagaaatt gcctgcaggg    300

tgatgcgcac agccaaaaaa ctgggtgtac agactgtggc ggtttatagt gaggctgaca    360

gaaattccat gcatgtagat atgcaggatg atcttgattt cacagagaaa ataaaattga    420

ggttcctgcc acagaatctg ctgacttagt tatgtctgca tccatctttc ccatcgaagg    480

cagatgaagc atattccatc ggccccgctc cctcccagca gagctaccta tctatggaga    540

aaatcattca agtggccaag acctctgctg cacaggctat ccatccagga tgcggttttc    600

tctcagaaaa catggaattt gctgaacttt gtaagc                              636


<210>  1865
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  1865


Met Ala Ala Ala Ser Ala Val Ser Val Leu Leu Val Ala Ala Glu Arg 
1               5                   10                  15      


Asn Arg Trp His Arg Leu Pro Ser Leu Leu Leu Pro Pro Arg Thr Trp 
            20                  25                  30          


Val Trp Arg Gln Arg Thr Met Lys Tyr Thr Thr Ala Thr Gly Arg Asn 
        35                  40                  45              


Ile Thr Lys Val Leu Ile Ala Asn Arg Gly Glu Ile Ala Cys Arg Val 
    50                  55                  60                  


Met Arg Thr Ala Lys Lys Leu Gly Val Gln Thr Val Ala Val Tyr Ser 
65                  70                  75                  80  


Glu Ala Asp Arg Asn Ser Met His Val Asp Met Gln Asp Asp Leu Asp 
                85                  90                  95      


Phe Thr Glu Lys Ile Lys Leu Arg Phe Leu Pro Gln Asn Leu Leu Thr 
            100                 105                 110         

<210>  1866
<211>  1124
<212>  DNA
<213>  Homo sapiens

<400>  1866
atggtttcat gtaacataca tattcctggt gtagcactta actccttttc cactttaaat     60

taaatgtttt ttttaatcat caaaaagaac aacatatctc aggttgtcta agtgttttta    120

tgtaaaacca acaaaaagaa caaatcagct tatatttttt atcttgatga ctcctgctcc    180

agaatcgcta gactaagaat taggtggcta cagatggtag aactaaacaa taagcaagag    240

acaataataa tggcccttaa ttattaacaa agtgccagag tctaggctaa gcactttatc    300

tatatctcat ttcattctca caacttatag gtgaatgagt aaactgagac ttaagggaac    360

tgaatcactt aaatgtcacc tggctaactg atggcagagc cagagcttga attcatgttg    420

gtctgacatc aaggtctttg gtcttctccc tacaccaagt tacctacaag aacaatgaca    480

ccacactctg cctgaaggct cacacctcat accagcatac gctcacctta cagggaaatg    540

ggtttatcca ggatcatgag acattagggt agatgaaagg agagctttgc agataacaaa    600

atagcctatc cttaataaat cctccactct ctggaaggag actgaggggc tttgtaaaac    660

attagtcagt tgctcatttt tatgggattg cttagctggg ctgtaaagat gaaggcatca    720

aataaactca aagtattttt aaattttttt gataatagag aaacttcgct aaccaactgt    780

tctttcttga gtgtatagcc ccatcttgtg gtaacttgct gcttctgcac ttcatatcca    840

tatttcctat tgttcacttt attctgtaga gcagcctgcc aagaatttta tttctgctgt    900

tttttttgct gctaaagaaa ggaactaagt caggatgtta acagaaaagt ccacataacc    960

ctagaattct tagtcaagga ataattcaag tcagcctaga gaccatgttg actttcctca   1020

tgtgtttcct tatgactcag taagttggca aggtcctgac tttagtctta ataaaacatt   1080

gaattgtagt aaaggttttt gtaataaaaa cttactttgg agat                    1124


<210>  1867
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  1867


Met Gly Leu Leu Ser Trp Ala Val Lys Met Lys Ala Ser Asn Lys Leu 
1               5                   10                  15      


Lys Val Phe Leu Asn Phe Phe Asp Asn Arg Glu Thr Ser Leu Thr Asn 
            20                  25                  30          


Cys Ser Phe Leu Ser Val 
        35              

<210>  1868
<211>  1133
<212>  DNA
<213>  Homo sapiens

<400>  1868
ggatgagtgc tcgtctgact acacaattgt gcttcctgtg attggggcca tcgtggttgg     60

tctctgcctt atgggtatgg gtgtctataa aatccgccta aggtgtcaat catctggata    120

ccagagaatc taattgttgc ccggggggaa tgaaaataat ggaatttaga gaactctttc    180

atcccttcca ggatggatgt tgggaaattc cctcagagtg tgggtccttc aaacaatgta    240

aaccaccatc ttctattcaa atgaagtgag tcatgtgtga tttaagttca ggcagcacat    300

caatttctaa atactttttg tttattttat gaaagatata gtgagctgtt tattttctag    360

tttcctttag aatattttag ccactcaaag tcaacatttg agatatgttg aattaacata    420

atatatgtaa agtagaataa gccttcaaat tataaaccaa gggtcaattg taactaatac    480

tactgtgtgt gcattgaaga ttttatttta cccttgatct taacaaagcc tttgctttgt    540

tatcaaatgg atttatccag gatcatgaga cattagggta gatgaaagga gagctttgca    600

gataacaaaa tagcctatcc ttaataaatc ctccactctc tggaaggaga ctgaggggct    660

ttgtaaaaca ttagtcagtt gctcattttt atgggattgc ttagctgggc tgtaaagatg    720

aaggcatcaa ataaactcaa agtattttta aatttttttg ataatagaga aacttcgcta    780

accaactgtt ctttcttgag tgtatagccc catcttgtgg taacttgctg cttctgcact    840

tcatatccat atttcctatt gttcacttta ttctgtagag cagcctgcca agaattttat    900

ttctgctgtt ttttttgctg ctaaagaaag gaactaagtc aggatgttaa cagaaaagtc    960

cacataaccc tagaattctt agtcaaggaa taattcaagt cagcctagag accatgttga   1020

ctttcctcat gtgtttcctt atgactcagt aagttggcaa ggtcctgact ttagtcttaa   1080

taaaacattg aattgtagta aaggtttttg taataaaaac ttactttgga gat          1133


<210>  1869
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  1869


Met Lys Ile Met Glu Phe Arg Glu Leu Phe His Pro Phe Gln Asp Gly 
1               5                   10                  15      


Cys Trp Glu Ile Pro Ser Glu Cys Gly Ser Phe Lys Gln Cys Lys Pro 
            20                  25                  30          


Pro Ser Ser Ile Gln Met Lys 
        35                  

<210>  1870
<211>  3321
<212>  DNA
<213>  Homo sapiens

<400>  1870
gtccccgccc ctccctgctc cgtaggggta ggagggggcc ggcggagttt ccctccccgc     60

ccagcggccc tgggcgggct tttcggctgc ttctcataag caggtggttt cgtttctccg    120

gcacaggtag gtttctctgg caccgattcg gggcctgccc ggacttcgcc gcacgctgca    180

gaacctcgcc cagcgcccac catgccccgg cagctcagcg cggcggccgc gctcttcgcg    240

tccctggccg taattttgca cgatggcagt caaatgagag caaaagcatt tccagaaacc    300

agagattatt ctcaacctac tgcagcagca acagtacagg acataaaaaa acctgtccag    360

caaccagcta agcaagcacc tcaccaaact ttagcagcaa gattcatgga tggtcatatc    420

acctttcaaa cagcggccac agtaaaaatt ccaacaacta ccccagcgac tacaaaaaac    480

actgcaacca ccagcccaat tacctacacc ctggtcacaa cccaggccac acccaacaac    540

tcacacacag ctcctccagt tactgaagtt acagtcggcc ctagcttagc cccttattca    600

ctgccaccca ccatcacccc accagctcat acaactggaa ccagttcatc aaccgtcagc    660

cacacaactg ggaacaccac tcaacccagt aaccagacca cccttccagc aactttatcg    720

atagcactgc acaaaagcac aaccggtcag aagcctgttc aacccaccca tgccccagga    780

acaacggcag ctgcccacaa taccacccgc acagctgcac ctgcctccac ggttcctggg    840

cccacccttg cacctcagcc atcgtcagtc aagactggaa tttatcaggt tctaaacgga    900

agcagactct gtataaaagc agagatgggg atacagctga ttgttcaaga caaggagtcg    960

gttttttcac ctcggagata cttcaacatc gaccccaacg caacgcaagc ctctgggaac   1020

tgtggcaccc gaaaatccaa ccttctgttg aattttcagg gcggatttgt gaatctcaca   1080

tttaccaagg atgaagaatc atattatatc agtgaagtgg gagcctattt gaccgtctca   1140

gatccagaga caatttacca aggaatcaaa catgcggtgg tgatgttcca gacagcagtc   1200

gggcattcct tcaagtgcgt gagtgaacag agcctccagt tgtcagccca cctgcaggtg   1260

aaaacaaccg atgtccaact tcaagccttt gattttgaag atgaccactt tggaaatgtg   1320

gatgagtgct cgtctgacta cacaattgtg cttcctgtga ttggggccat cgtggttggt   1380

ctctgcctta tgggtatggg tgtctataaa atccgcctaa ggtgtcaatc atctggatac   1440

cagagaatct aattgttgcc cggggggaat gaaaataatg gaatttagag aactctttca   1500

tcccttccag gatggatgtt gggaaattcc ctcagagtgt gggtccttca aacaatgtaa   1560

accaccatct tctattcaaa tgaagtgagt catgtgtgat ttaagttcag gcagcacatc   1620

aatttctaaa tactttttgt ttattttatg aaagatatag tgagctgttt attttctagt   1680

ttcctttaga atattttagc cactcaaagt caacatttga gatatgttga attaacataa   1740

tatatgtaaa gtagaataag ccttcaaatt ataaaccaag ggtcaattgt aactaatact   1800

actgtgtgtg cattgaagat tttattttac ccttgatctt aacaaagcct ttgctttgtt   1860

atcaaatgga ctttcagtgc ttttactatc tgtgttttat ggtttcatgt aacatacata   1920

ttcctggtgt agcacttaac tccttttcca ctttaaattt gtttttgttt tttgagacgg   1980

agtttcactc ttgtcaccca ggctggagta cagtggcacg atctcggctt atggcaacct   2040

ccgcctcccg ggttcaagtg attctcctgc ttcagcttcc cgagtagctg ggattacagg   2100

cacacactac cacgcctggc taatttttgt atttttatta tagacggggt ttcaccatgt   2160

tggccagact ggtcttgaac tcttgacctc aggtgatcca cccacctcag cctcccaaag   2220

tgctgggatt acaggcatga gccattgcgc ccggccttaa atgttttttt taatcatcaa   2280

aaagaacaac atatctcagg ttgtctaagt gtttttatgt aaaaccaaca aaaagaacaa   2340

atcagcttat attttttatc ttgatgactc ctgctccaga atcgctagac taagaattag   2400

gtggctacag atggtagaac taaacaataa gcaagagaca ataataatgg cccttaatta   2460

ttaacaaagt gccagagtct aggctaagca ctttatctat atctcatttc attctcacaa   2520

cttataggtg aatgagtaaa ctgagactta agggaactga atcacttaaa tgtcacctgg   2580

ctaactgatg gcagagccag agcttgaatt catgttggtc tgacatcaag gtctttggtc   2640

ttctccctac accaagttac ctacaagaac aatgacacca cactctgcct gaaggctcac   2700

acctcatacc agcatacgct caccttacag ggaaatgggt ttatccagga tcatgagaca   2760

ttagggtaga tgaaaggaga gctttgcaga taacaaaata gcctatcctt aataaatcct   2820

ccactctctg gaaggagact gaggggcttt gtaaaacatt agtcagttgc tcatttttat   2880

gggattgctt agctgggctg taaagatgaa ggcatcaaat aaactcaaag tatttttaaa   2940

tttttttgat aatagagaaa cttcgctaac caactgttct ttcttgagtg tatagcccca   3000

tcttgtggta acttgctgct tctgcacttc atatccatat ttcctattgt tcactttatt   3060

ctgtagagca gcctgccaag aattttattt ctgctgtttt ttttgctgct aaagaaagga   3120

actaagtcag gatgttaaca gaaaagtcca cataacccta gaattcttag tcaaggaata   3180

attcaagtca gcctagagac catgttgact ttcctcatgt gtttccttat gactcagtaa   3240

gttggcaagg tcctgacttt agtcttaata aaacattgaa ttgtagtaaa ggtttttgta   3300

ataaaaactt actttggaga t                                             3321


<210>  1871
<211>  416
<212>  PRT
<213>  Homo sapiens

<400>  1871


Met Pro Arg Gln Leu Ser Ala Ala Ala Ala Leu Phe Ala Ser Leu Ala 
1               5                   10                  15      


Val Ile Leu His Asp Gly Ser Gln Met Arg Ala Lys Ala Phe Pro Glu 
            20                  25                  30          


Thr Arg Asp Tyr Ser Gln Pro Thr Ala Ala Ala Thr Val Gln Asp Ile 
        35                  40                  45              


Lys Lys Pro Val Gln Gln Pro Ala Lys Gln Ala Pro His Gln Thr Leu 
    50                  55                  60                  


Ala Ala Arg Phe Met Asp Gly His Ile Thr Phe Gln Thr Ala Ala Thr 
65                  70                  75                  80  


Val Lys Ile Pro Thr Thr Thr Pro Ala Thr Thr Lys Asn Thr Ala Thr 
                85                  90                  95      


Thr Ser Pro Ile Thr Tyr Thr Leu Val Thr Thr Gln Ala Thr Pro Asn 
            100                 105                 110         


Asn Ser His Thr Ala Pro Pro Val Thr Glu Val Thr Val Gly Pro Ser 
        115                 120                 125             


Leu Ala Pro Tyr Ser Leu Pro Pro Thr Ile Thr Pro Pro Ala His Thr 
    130                 135                 140                 


Thr Gly Thr Ser Ser Ser Thr Val Ser His Thr Thr Gly Asn Thr Thr 
145                 150                 155                 160 


Gln Pro Ser Asn Gln Thr Thr Leu Pro Ala Thr Leu Ser Ile Ala Leu 
                165                 170                 175     


His Lys Ser Thr Thr Gly Gln Lys Pro Val Gln Pro Thr His Ala Pro 
            180                 185                 190         


Gly Thr Thr Ala Ala Ala His Asn Thr Thr Arg Thr Ala Ala Pro Ala 
        195                 200                 205             


Ser Thr Val Pro Gly Pro Thr Leu Ala Pro Gln Pro Ser Ser Val Lys 
    210                 215                 220                 


Thr Gly Ile Tyr Gln Val Leu Asn Gly Ser Arg Leu Cys Ile Lys Ala 
225                 230                 235                 240 


Glu Met Gly Ile Gln Leu Ile Val Gln Asp Lys Glu Ser Val Phe Ser 
                245                 250                 255     


Pro Arg Arg Tyr Phe Asn Ile Asp Pro Asn Ala Thr Gln Ala Ser Gly 
            260                 265                 270         


Asn Cys Gly Thr Arg Lys Ser Asn Leu Leu Leu Asn Phe Gln Gly Gly 
        275                 280                 285             


Phe Val Asn Leu Thr Phe Thr Lys Asp Glu Glu Ser Tyr Tyr Ile Ser 
    290                 295                 300                 


Glu Val Gly Ala Tyr Leu Thr Val Ser Asp Pro Glu Thr Ile Tyr Gln 
305                 310                 315                 320 


Gly Ile Lys His Ala Val Val Met Phe Gln Thr Ala Val Gly His Ser 
                325                 330                 335     


Phe Lys Cys Val Ser Glu Gln Ser Leu Gln Leu Ser Ala His Leu Gln 
            340                 345                 350         


Val Lys Thr Thr Asp Val Gln Leu Gln Ala Phe Asp Phe Glu Asp Asp 
        355                 360                 365             


His Phe Gly Asn Val Asp Glu Cys Ser Ser Asp Tyr Thr Ile Val Leu 
    370                 375                 380                 


Pro Val Ile Gly Ala Ile Val Val Gly Leu Cys Leu Met Gly Met Gly 
385                 390                 395                 400 


Val Tyr Lys Ile Arg Leu Arg Cys Gln Ser Ser Gly Tyr Gln Arg Ile 
                405                 410                 415     

<210>  1872
<211>  776
<212>  DNA
<213>  Homo sapiens

<400>  1872
gaggcccggg ccccggcggc tgcgccgagt ccccgcccct ccctgctccg taggggtagg     60

agggggccgg cggagtttcc ctccccgccc agcggccctg ggcgggcttt tcggctgctt    120

ctcataagca ggtggtttcg tttctccggc acaggtaggt ttctctggca ccgattcggg    180

gcctgcccgg acttcgccgc acgctgcaga acctcgccca gcgcccacca tgccccggca    240

gctcagcgcg gcggccgcgc tcttcgcgtc cctggccgta attttgcacg atggcagtca    300

aatgagagca aaagcatttc cagaaaccag agattattct caacctactg cagcagcaac    360

agtacaggac ataaaaaaac ctgtccagca accagctaag caagcacctc accaaacttt    420

agcagcaaga ttcatggatg gtcatatcac ctttcaaaca gcggccacag taaaaattcc    480

aacaactacc ccagcgacta caaaaaacac tgcaaccacc agcccaatta cctacaccct    540

ggtcacaacc caggccacac ccaacaactc acacacagct cctccagtta ctgaagttac    600

agtcggccct agcttagccc cttattcact gccacccacc atcaccccac cagctcatac    660

aactggaacc agttcatcaa ccgtcagcca cacaactggg aacaccactc aacccagtaa    720

ccagaccacc cttccagcaa ctttatcgat agcactgcac aaaagcacaa ccggtc        776


<210>  1873
<211>  181
<212>  PRT
<213>  Homo sapiens

<400>  1873


Met Pro Arg Gln Leu Ser Ala Ala Ala Ala Leu Phe Ala Ser Leu Ala 
1               5                   10                  15      


Val Ile Leu His Asp Gly Ser Gln Met Arg Ala Lys Ala Phe Pro Glu 
            20                  25                  30          


Thr Arg Asp Tyr Ser Gln Pro Thr Ala Ala Ala Thr Val Gln Asp Ile 
        35                  40                  45              


Lys Lys Pro Val Gln Gln Pro Ala Lys Gln Ala Pro His Gln Thr Leu 
    50                  55                  60                  


Ala Ala Arg Phe Met Asp Gly His Ile Thr Phe Gln Thr Ala Ala Thr 
65                  70                  75                  80  


Val Lys Ile Pro Thr Thr Thr Pro Ala Thr Thr Lys Asn Thr Ala Thr 
                85                  90                  95      


Thr Ser Pro Ile Thr Tyr Thr Leu Val Thr Thr Gln Ala Thr Pro Asn 
            100                 105                 110         


Asn Ser His Thr Ala Pro Pro Val Thr Glu Val Thr Val Gly Pro Ser 
        115                 120                 125             


Leu Ala Pro Tyr Ser Leu Pro Pro Thr Ile Thr Pro Pro Ala His Thr 
    130                 135                 140                 


Thr Gly Thr Ser Ser Ser Thr Val Ser His Thr Thr Gly Asn Thr Thr 
145                 150                 155                 160 


Gln Pro Ser Asn Gln Thr Thr Leu Pro Ala Thr Leu Ser Ile Ala Leu 
                165                 170                 175     


His Lys Ser Thr Thr 
            180     

<210>  1874
<211>  10343
<212>  DNA
<213>  Homo sapiens

<400>  1874
ttgctgtgtg aggcagaacc tgcgggggca ggggcgggct ggttccctgg ccagccattg     60

gcagagtccg caggctaggg ctgtcaatca tgctggccgg cgtggccccg cctccgccgg    120

cgcggccccg cctccgccgg cgcagcgtct gggacgcaag gcgccgtggg ggctgccggg    180

acgggtccaa gatggacggc cgctcaggtt ctgcttttac ctgcggccca gagccccatt    240

cattgccccg gtgctgagcg gcgccgcgag tcggcccgag gcctccgggg actgccgtgc    300

cgggcgggag accgccatgg cgaccctgga aaagctgatg aaggccttcg agtccctcaa    360

gtccttccag cagcagcagc agcagcagca gcagcagcag cagcagcagc agcagcagca    420

gcagcaacag ccgccaccgc cgccgccgcc gccgccgcct cctcagcttc ctcagccgcc    480

gccgcaggca cagccgctgc tgcctcagcc gcagccgccc ccgccgccgc ccccgccgcc    540

acccggcccg gctgtggctg aggagccgct gcaccgacca aagaaagaac tttcagctac    600

caagaaagac cgtgtgaatc attgtctgac aatatgtgaa aacatagtgg cacagtctgt    660

cagaaattct ccagaatttc agaaacttct gggcatcgct atggaacttt ttctgctgtg    720

cagtgatgac gcagagtcag atgtcaggat ggtggctgac gaatgcctca acaaagttat    780

caaagctttg atggattcta atcttccaag gttacagctc gagctctata aggaaattaa    840

aaagaatggt gcccctcgga gtttgcgtgc tgccctgtgg aggtttgctg agctggctca    900

cctggttcgg cctcagaaat gcaggcctta cctggtgaac cttctgccgt gcctgactcg    960

aacaagcaag agacccgaag aatcagtcca ggagaccttg gctgcagctg ttcccaaaat   1020

tatggcttct tttggcaatt ttgcaaatga caatgaaatt aaggttttgt taaaggcctt   1080

catagcgaac ctgaagtcaa gctcccccac cattcggcgg acagcggctg gatcagcagt   1140

gagcatctgc cagcactcaa gaaggacaca atatttctat agttggctac taaatgtgct   1200

cttaggctta ctcgttcctg tcgaggatga acactccact ctgctgattc ttggcgtgct   1260

gctcaccctg aggtatttgg tgcccttgct gcagcagcag gtcaaggaca caagcctgaa   1320

aggcagcttc ggagtgacaa ggaaagaaat ggaagtctct ccttctgcag agcagcttgt   1380

ccaggtttat gaactgacgt tacatcatac acagcaccaa gaccacaatg ttgtgaccgg   1440

agccctggag ctgttgcagc agctcttcag aacgcctcca cccgagcttc tgcaaaccct   1500

gaccgcagtc gggggcattg ggcagctcac cgctgctaag gaggagtctg gtggccgaag   1560

ccgtagtggg agtattgtgg aacttatagc tggagggggt tcctcatgca gccctgtcct   1620

ttcaagaaaa caaaaaggca aagtgctctt aggagaagaa gaagccttgg aggatgactc   1680

tgaatcgaga tcggatgtca gcagctctgc cttaacagcc tcagtgaagg atgagatcag   1740

tggagagctg gctgcttctt caggggtttc cactccaggg tcagcaggtc atgacatcat   1800

cacagaacag ccacggtcac agcacacact gcaggcggac tcagtggatc tggccagctg   1860

tgacttgaca agctctgcca ctgatgggga tgaggaggat atcttgagcc acagctccag   1920

ccaggtcagc gccgtcccat ctgaccctgc catggacctg aatgatggga cccaggcctc   1980

gtcgcccatc agcgacagct cccagaccac caccgaaggg cctgattcag ctgttacccc   2040

ttcagacagt tctgaaattg tgttagacgg taccgacaac cagtatttgg gcctgcagat   2100

tggacagccc caggatgaag atgaggaagc cacaggtatt cttcctgatg aagcctcgga   2160

ggccttcagg aactcttcca tggcccttca acaggcacat ttattgaaaa acatgagtca   2220

ctgcaggcag ccttctgaca gcagtgttga taaatttgtg ttgagagatg aagctactga   2280

accgggtgat caagaaaaca agccttgccg catcaaaggt gacattggac agtccactga   2340

tgatgactct gcacctcttg tccattgtgt ccgcctttta tctgcttcgt ttttgctaac   2400

agggggaaaa aatgtgctgg ttccggacag ggatgtgagg gtcagcgtga aggccctggc   2460

cctcagctgt gtgggagcag ctgtggccct ccacccggaa tctttcttca gcaaactcta   2520

taaagttcct cttgacacca cggaataccc tgaggaacag tatgtctcag acatcttgaa   2580

ctacatcgat catggagacc cacaggttcg aggagccact gccattctct gtgggaccct   2640

catctgctcc atcctcagca ggtcccgctt ccacgtggga gattggatgg gcaccattag   2700

aaccctcaca ggaaatacat tttctttggc ggattgcatt cctttgctgc ggaaaacact   2760

gaaggatgag tcttctgtta cttgcaagtt agcttgtaca gctgtgagga actgtgtcat   2820

gagtctctgc agcagcagct acagtgagtt aggactgcag ctgatcatcg atgtgctgac   2880

tctgaggaac agttcctatt ggctggtgag gacagagctt ctggaaaccc ttgcagagat   2940

tgacttcagg ctggtgagct ttttggaggc aaaagcagaa aacttacaca gaggggctca   3000

tcattataca gggcttttaa aactgcaaga acgagtgctc aataatgttg tcatccattt   3060

gcttggagat gaagacccca gggtgcgaca tgttgccgca gcatcactaa ttaggcttgt   3120

cccaaagctg ttttataaat gtgaccaagg acaagctgat ccagtagtgg ccgtggcaag   3180

agatcaaagc agtgtttacc tgaaacttct catgcatgag acgcagcctc catctcattt   3240

ctccgtcagc acaataacca gaatatatag aggctataac ctactaccaa gcataacaga   3300

cgtcactatg gaaaataacc tttcaagagt tattgcagca gtttctcatg aactaatcac   3360

atcaaccacc agagcactca catttggatg ctgtgaagct ttgtgtcttc tttccactgc   3420

cttcccagtt tgcatttgga gtttaggttg gcactgtgga gtgcctccac tgagtgcctc   3480

agatgagtct aggaagagct gtaccgttgg gatggccaca atgattctga ccctgctctc   3540

gtcagcttgg ttcccattgg atctctcagc ccatcaagat gctttgattt tggccggaaa   3600

cttgcttgca gccagtgctc ccaaatctct gagaagttca tgggcctctg aagaagaagc   3660

caacccagca gccaccaagc aagaggaggt ctggccagcc ctgggggacc gggccctggt   3720

gcccatggtg gagcagctct tctctcacct gctgaaggtg attaacattt gtgcccacgt   3780

cctggatgac gtggctcctg gacccgcaat aaaggcagcc ttgccttctc taacaaaccc   3840

cccttctcta agtcccatcc gacgaaaggg gaaggagaaa gaaccaggag aacaagcatc   3900

tgtaccgttg agtcccaaga aaggcagtga ggccagtgca gcttctagac aatctgatac   3960

ctcaggtcct gttacaacaa gtaaatcctc atcactgggg agtttctatc atcttccttc   4020

atacctcaaa ctgcatgatg tcctgaaagc tacacacgct aactacaagg tcacgctgga   4080

tcttcagaac agcacggaaa agtttggagg gtttctccgc tcagccttgg atgttctttc   4140

tcagatacta gagctggcca cactgcagga cattgggaag tgtgttgaag agatcctagg   4200

atacctgaaa tcctgcttta gtcgagaacc aatgatggca actgtttgtg ttcaacaatt   4260

gttgaagact ctctttggca caaacttggc ctcccagttt gatggcttat cttccaaccc   4320

cagcaagtca caaggccgag cacagcgcct tggctcctcc agtgtgaggc caggcttgta   4380

ccactactgc ttcatggccc cgtacaccca cttcacccag gccctcgctg acgccagcct   4440

gaggaacatg gtgcaggcgg agcaggagaa cgacacctcg ggatggtttg atgtcctcca   4500

gaaagtgtct acccagttga agacaaacct cacgagtgtc acaaagaacc gtgcagataa   4560

gaatgctatt cataatcaca ttcgtttgtt tgaacctctt gttataaaag ctttaaaaca   4620

gtacacgact acaacatgtg tgcagttaca gaagcaggtt ttagatttgc tggcgcagct   4680

ggttcagtta cgggttaatt actgtcttct ggattcagat caggtgttta ttggctttgt   4740

attgaaacag tttgaataca ttgaagtggg ccagttcagg gaatcagagg caatcattcc   4800

aaacatcttt ttcttcttgg tattactatc ttatgaacgc tatcattcaa aacagatcat   4860

tggaattcct aaaatcattc agctctgtga tggcatcatg gccagtggaa ggaaggctgt   4920

gacacatgcc ataccggctc tgcagcccat agtccacgac ctctttgtat taagaggaac   4980

aaataaagct gatgcaggaa aagagcttga aacccaaaaa gaggtggtgg tgtcaatgtt   5040

actgagactc atccagtacc atcaggtgtt ggagatgttc attcttgtcc tgcagcagtg   5100

ccacaaggag aatgaagaca agtggaagcg actgtctcga cagatagctg acatcatcct   5160

cccaatgtta gccaaacagc agatgcacat tgactctcat gaagcccttg gagtgttaaa   5220

tacattattt gagattttgg ccccttcctc cctccgtccg gtagacatgc ttttacggag   5280

tatgttcgtc actccaaaca caatggcgtc cgtgagcact gttcaactgt ggatatcggg   5340

aattctggcc attttgaggg ttctgatttc ccagtcaact gaagatattg ttctttctcg   5400

tattcaggag ctctccttct ctccgtattt aatctcctgt acagtaatta ataggttaag   5460

agatggggac agtacttcaa cgctagaaga acacagtgaa gggaaacaaa taaagaattt   5520

gccagaagaa acattttcaa ggtttctatt acaactggtt ggtattcttt tagaagacat   5580

tgttacaaaa cagctgaagg tggaaatgag tgagcagcaa catactttct attgccagga   5640

actaggcaca ctgctaatgt gtctgatcca catcttcaag tctggaatgt tccggagaat   5700

cacagcagct gccactaggc tgttccgcag tgatggctgt ggcggcagtt tctacaccct   5760

ggacagcttg aacttgcggg ctcgttccat gatcaccacc cacccggccc tggtgctgct   5820

ctggtgtcag atactgctgc ttgtcaacca caccgactac cgctggtggg cagaagtgca   5880

gcagaccccg aaaagacaca gtctgtccag cacaaagtta cttagtcccc agatgtctgg   5940

agaagaggag gattctgact tggcagccaa acttggaatg tgcaatagag aaatagtacg   6000

aagaggggct ctcattctct tctgtgatta tgtctgtcag aacctccatg actccgagca   6060

cttaacgtgg ctcattgtaa atcacattca agatctgatc agcctttccc acgagcctcc   6120

agtacaggac ttcatcagtg ccgttcatcg gaactctgct gccagcggcc tgttcatcca   6180

ggcaattcag tctcgttgtg aaaacctttc aactccaacc atgctgaaga aaactcttca   6240

gtgcttggag gggatccatc tcagccagtc gggagctgtg ctcacgctgt atgtggacag   6300

gcttctgtgc acccctttcc gtgtgctggc tcgcatggtc gacatccttg cttgtcgccg   6360

ggtagaaatg cttctggctg caaatttaca gagcagcatg gcccagttgc caatggaaga   6420

actcaacaga atccaggaat accttcagag cagcgggctc gctcagagac accaaaggct   6480

ctattccctg ctggacaggt ttcgtctctc caccatgcaa gactcactta gtccctctcc   6540

tccagtctct tcccacccgc tggacgggga tgggcacgtg tcactggaaa cagtgagtcc   6600

ggacaaagac tggtacgttc atcttgtcaa atcccagtgt tggaccaggt cagattctgc   6660

actgctggaa ggtgcagagc tggtgaatcg gattcctgct gaagatatga atgccttcat   6720

gatgaactcg gagttcaacc taagcctgct agctccatgc ttaagcctag ggatgagtga   6780

aatttctggt ggccagaaga gtgccctttt tgaagcagcc cgtgaggtga ctctggcccg   6840

tgtgagcggc accgtgcagc agctccctgc tgtccatcat gtcttccagc ccgagctgcc   6900

tgcagagccg gcggcctact ggagcaagtt gaatgatctg tttggggatg ctgcactgta   6960

tcagtccctg cccactctgg cccgggccct ggcacagtac ctggtggtgg tctccaaact   7020

gcccagtcat ttgcaccttc ctcctgagaa agagaaggac attgtgaaat tcgtggtggc   7080

aacccttgag gccctgtcct ggcatttgat ccatgagcag atcccgctga gtctggatct   7140

ccaggcaggg ctggactgct gctgcctggc cctgcagctg cctggcctct ggagcgtggt   7200

ctcctccaca gagtttgtga cccacgcctg ctccctcatc tactgtgtgc acttcatcct   7260

ggaggccgtt gcagtgcagc ctggagagca gcttcttagt ccagaaagaa ggacaaatac   7320

cccaaaagcc atcagcgagg aggaggagga agtagatcca aacacacaga atcctaagta   7380

tatcactgca gcctgtgaga tggtggcaga aatggtggag tctctgcagt cggtgttggc   7440

cttgggtcat aaaaggaata gcggcgtgcc ggcgtttctc acgccattgc taaggaacat   7500

catcatcagc ctggcccgcc tgccccttgt caacagctac acacgtgtgc ccccactggt   7560

gtggaagctt ggatggtcac ccaaaccggg aggggatttt ggcacagcat tccctgagat   7620

ccccgtggag ttcctccagg aaaaggaagt ctttaaggag ttcatctacc gcatcaacac   7680

actaggctgg accagtcgta ctcagtttga agaaacttgg gccaccctcc ttggtgtcct   7740

ggtgacgcag cccctcgtga tggagcagga ggagagccca ccagaagaag acacagagag   7800

gacccagatc aacgtcctgg ccgtgcaggc catcacctca ctggtgctca gtgcaatgac   7860

tgtgcctgtg gccggcaacc cagctgtaag ctgcttggag cagcagcccc ggaacaagcc   7920

tctgaaagct ctcgacacca ggtttgggag gaagctgagc attatcagag ggattgtgga   7980

gcaagagatt caagcaatgg tttcaaagag agagaatatt gccacccatc atttatatca   8040

ggcatgggat cctgtccctt ctctgtctcc ggctactaca ggtgccctca tcagccacga   8100

gaagctgctg ctacagatca accccgagcg ggagctgggg agcatgagct acaaactcgg   8160

ccaggtgtcc atacactccg tgtggctggg gaacagcatc acacccctga gggaggagga   8220

atgggacgag gaagaggagg aggaggccga cgcccctgca ccttcgtcac cacccacgtc   8280

tccagtcaac tccaggaaac accgggctgg agttgacatc cactcctgtt cgcagttttt   8340

gcttgagttg tacagccgct ggatcctgcc gtccagctca gccaggagga ccccggccat   8400

cctgatcagt gaggtggtca gatcccttct agtggtctca gacttgttca ccgagcgcaa   8460

ccagtttgag ctgatgtatg tgacgctgac agaactgcga agggtgcacc cttcagaaga   8520

cgagatcctc gctcagtacc tggtgcctgc cacctgcaag gcagctgccg tccttgggat   8580

ggacaaggcc gtggcggagc ctgtcagccg cctgctggag agcacgctca ggagcagcca   8640

cctgcccagc agggttggag ccctgcacgg cgtcctctat gtgctggagt gcgacctgct   8700

ggacgacact gccaagcagc tcatcccggt catcagcgac tatctcctct ccaacctgaa   8760

agggatcgcc cactgcgtga acattcacag ccagcagcac gtactggtca tgtgtgccac   8820

tgcgttttac ctcattgaga actatcctct ggacgtaggg ccggaatttt cagcatcaat   8880

aatacagatg tgtggggtga tgctgtctgg aagtgaggag tccaccccct ccatcattta   8940

ccactgtgcc ctcagaggcc tggagcgcct cctgctctct gagcagctct cccgcctgga   9000

tgcagaatcg ctggtcaagc tgagtgtgga cagagtgaac gtgcacagcc cgcaccgggc   9060

catggcggct ctgggcctga tgctcacctg catgtacaca ggaaaggaga aagtcagtcc   9120

gggtagaact tcagacccta atcctgcagc ccccgacagc gagtcagtga ttgttgctat   9180

ggagcgggta tctgttcttt ttgataggat caggaaaggc tttccttgtg aagccagagt   9240

ggtggccagg atcctgcccc agtttctaga cgacttcttc ccaccccagg acatcatgaa   9300

caaagtcatc ggagagtttc tgtccaacca gcagccatac ccccagttca tggccaccgt   9360

ggtgtataag gtgtttcaga ctctgcacag caccgggcag tcgtccatgg tccgggactg   9420

ggtcatgctg tccctctcca acttcacgca gagggccccg gtcgccatgg ccacgtggag   9480

cctctcctgc ttctttgtca gcgcgtccac cagcccgtgg gtcgcggcga tcctcccaca   9540

tgtcatcagc aggatgggca agctggagca ggtggacgtg aaccttttct gcctggtcgc   9600

cacagacttc tacagacacc agatagagga ggagctcgac cgcagggcct tccagtctgt   9660

gcttgaggtg gttgcagccc caggaagccc atatcaccgg ctgctgactt gtttacgaaa   9720

tgtccacaag gtcaccacct gctgagcgcc atggtgggag agactgtgag gcggcagctg   9780

gggccggagc ctttggaagt ctgcgccctt gtgccctgcc tccaccgagc cagcttggtc   9840

cctatgggct tccgcacatg ccgcgggcgg ccaggcaacg tgcgtgtctc tgccatgtgg   9900

cagaagtgct ctttgtggca gtggccaggc agggagtgtc tgcagtcctg gtggggctga   9960

gcctgaggcc ttccagaaag caggagcagc tgtgctgcac cccatgtggg tgaccaggtc  10020

ctttctcctg atagtcacct gctggttgtt gccaggttgc agctgctctt gcatctgggc  10080

cagaagtcct ccctcctgca ggctggctgt tggcccctct gctgtcctgc agtagaaggt  10140

gccgtgagca ggctttggga acactggcct gggtctccct ggtggggtgt gcatgccacg  10200

ccccgtgtct ggatgcacag atgccatggc ctgtgctggg ccagtggctg ggggtgctag  10260

acacccggca ccattctccc ttctctcttt tcttctcagg atttaaaatt taattatatc  10320

agtaaagaga ttaattttaa cgt                                          10343


<210>  1875
<211>  3142
<212>  PRT
<213>  Homo sapiens

<400>  1875


Met Ala Thr Leu Glu Lys Leu Met Lys Ala Phe Glu Ser Leu Lys Ser 
1               5                   10                  15      


Phe Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
            20                  25                  30          


Gln Gln Gln Gln Gln Gln Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro 
        35                  40                  45              


Pro Gln Leu Pro Gln Pro Pro Pro Gln Ala Gln Pro Leu Leu Pro Gln 
    50                  55                  60                  


Pro Gln Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Gly Pro Ala Val 
65                  70                  75                  80  


Ala Glu Glu Pro Leu His Arg Pro Lys Lys Glu Leu Ser Ala Thr Lys 
                85                  90                  95      


Lys Asp Arg Val Asn His Cys Leu Thr Ile Cys Glu Asn Ile Val Ala 
            100                 105                 110         


Gln Ser Val Arg Asn Ser Pro Glu Phe Gln Lys Leu Leu Gly Ile Ala 
        115                 120                 125             


Met Glu Leu Phe Leu Leu Cys Ser Asp Asp Ala Glu Ser Asp Val Arg 
    130                 135                 140                 


Met Val Ala Asp Glu Cys Leu Asn Lys Val Ile Lys Ala Leu Met Asp 
145                 150                 155                 160 


Ser Asn Leu Pro Arg Leu Gln Leu Glu Leu Tyr Lys Glu Ile Lys Lys 
                165                 170                 175     


Asn Gly Ala Pro Arg Ser Leu Arg Ala Ala Leu Trp Arg Phe Ala Glu 
            180                 185                 190         


Leu Ala His Leu Val Arg Pro Gln Lys Cys Arg Pro Tyr Leu Val Asn 
        195                 200                 205             


Leu Leu Pro Cys Leu Thr Arg Thr Ser Lys Arg Pro Glu Glu Ser Val 
    210                 215                 220                 


Gln Glu Thr Leu Ala Ala Ala Val Pro Lys Ile Met Ala Ser Phe Gly 
225                 230                 235                 240 


Asn Phe Ala Asn Asp Asn Glu Ile Lys Val Leu Leu Lys Ala Phe Ile 
                245                 250                 255     


Ala Asn Leu Lys Ser Ser Ser Pro Thr Ile Arg Arg Thr Ala Ala Gly 
            260                 265                 270         


Ser Ala Val Ser Ile Cys Gln His Ser Arg Arg Thr Gln Tyr Phe Tyr 
        275                 280                 285             


Ser Trp Leu Leu Asn Val Leu Leu Gly Leu Leu Val Pro Val Glu Asp 
    290                 295                 300                 


Glu His Ser Thr Leu Leu Ile Leu Gly Val Leu Leu Thr Leu Arg Tyr 
305                 310                 315                 320 


Leu Val Pro Leu Leu Gln Gln Gln Val Lys Asp Thr Ser Leu Lys Gly 
                325                 330                 335     


Ser Phe Gly Val Thr Arg Lys Glu Met Glu Val Ser Pro Ser Ala Glu 
            340                 345                 350         


Gln Leu Val Gln Val Tyr Glu Leu Thr Leu His His Thr Gln His Gln 
        355                 360                 365             


Asp His Asn Val Val Thr Gly Ala Leu Glu Leu Leu Gln Gln Leu Phe 
    370                 375                 380                 


Arg Thr Pro Pro Pro Glu Leu Leu Gln Thr Leu Thr Ala Val Gly Gly 
385                 390                 395                 400 


Ile Gly Gln Leu Thr Ala Ala Lys Glu Glu Ser Gly Gly Arg Ser Arg 
                405                 410                 415     


Ser Gly Ser Ile Val Glu Leu Ile Ala Gly Gly Gly Ser Ser Cys Ser 
            420                 425                 430         


Pro Val Leu Ser Arg Lys Gln Lys Gly Lys Val Leu Leu Gly Glu Glu 
        435                 440                 445             


Glu Ala Leu Glu Asp Asp Ser Glu Ser Arg Ser Asp Val Ser Ser Ser 
    450                 455                 460                 


Ala Leu Thr Ala Ser Val Lys Asp Glu Ile Ser Gly Glu Leu Ala Ala 
465                 470                 475                 480 


Ser Ser Gly Val Ser Thr Pro Gly Ser Ala Gly His Asp Ile Ile Thr 
                485                 490                 495     


Glu Gln Pro Arg Ser Gln His Thr Leu Gln Ala Asp Ser Val Asp Leu 
            500                 505                 510         


Ala Ser Cys Asp Leu Thr Ser Ser Ala Thr Asp Gly Asp Glu Glu Asp 
        515                 520                 525             


Ile Leu Ser His Ser Ser Ser Gln Val Ser Ala Val Pro Ser Asp Pro 
    530                 535                 540                 


Ala Met Asp Leu Asn Asp Gly Thr Gln Ala Ser Ser Pro Ile Ser Asp 
545                 550                 555                 560 


Ser Ser Gln Thr Thr Thr Glu Gly Pro Asp Ser Ala Val Thr Pro Ser 
                565                 570                 575     


Asp Ser Ser Glu Ile Val Leu Asp Gly Thr Asp Asn Gln Tyr Leu Gly 
            580                 585                 590         


Leu Gln Ile Gly Gln Pro Gln Asp Glu Asp Glu Glu Ala Thr Gly Ile 
        595                 600                 605             


Leu Pro Asp Glu Ala Ser Glu Ala Phe Arg Asn Ser Ser Met Ala Leu 
    610                 615                 620                 


Gln Gln Ala His Leu Leu Lys Asn Met Ser His Cys Arg Gln Pro Ser 
625                 630                 635                 640 


Asp Ser Ser Val Asp Lys Phe Val Leu Arg Asp Glu Ala Thr Glu Pro 
                645                 650                 655     


Gly Asp Gln Glu Asn Lys Pro Cys Arg Ile Lys Gly Asp Ile Gly Gln 
            660                 665                 670         


Ser Thr Asp Asp Asp Ser Ala Pro Leu Val His Cys Val Arg Leu Leu 
        675                 680                 685             


Ser Ala Ser Phe Leu Leu Thr Gly Gly Lys Asn Val Leu Val Pro Asp 
    690                 695                 700                 


Arg Asp Val Arg Val Ser Val Lys Ala Leu Ala Leu Ser Cys Val Gly 
705                 710                 715                 720 


Ala Ala Val Ala Leu His Pro Glu Ser Phe Phe Ser Lys Leu Tyr Lys 
                725                 730                 735     


Val Pro Leu Asp Thr Thr Glu Tyr Pro Glu Glu Gln Tyr Val Ser Asp 
            740                 745                 750         


Ile Leu Asn Tyr Ile Asp His Gly Asp Pro Gln Val Arg Gly Ala Thr 
        755                 760                 765             


Ala Ile Leu Cys Gly Thr Leu Ile Cys Ser Ile Leu Ser Arg Ser Arg 
    770                 775                 780                 


Phe His Val Gly Asp Trp Met Gly Thr Ile Arg Thr Leu Thr Gly Asn 
785                 790                 795                 800 


Thr Phe Ser Leu Ala Asp Cys Ile Pro Leu Leu Arg Lys Thr Leu Lys 
                805                 810                 815     


Asp Glu Ser Ser Val Thr Cys Lys Leu Ala Cys Thr Ala Val Arg Asn 
            820                 825                 830         


Cys Val Met Ser Leu Cys Ser Ser Ser Tyr Ser Glu Leu Gly Leu Gln 
        835                 840                 845             


Leu Ile Ile Asp Val Leu Thr Leu Arg Asn Ser Ser Tyr Trp Leu Val 
    850                 855                 860                 


Arg Thr Glu Leu Leu Glu Thr Leu Ala Glu Ile Asp Phe Arg Leu Val 
865                 870                 875                 880 


Ser Phe Leu Glu Ala Lys Ala Glu Asn Leu His Arg Gly Ala His His 
                885                 890                 895     


Tyr Thr Gly Leu Leu Lys Leu Gln Glu Arg Val Leu Asn Asn Val Val 
            900                 905                 910         


Ile His Leu Leu Gly Asp Glu Asp Pro Arg Val Arg His Val Ala Ala 
        915                 920                 925             


Ala Ser Leu Ile Arg Leu Val Pro Lys Leu Phe Tyr Lys Cys Asp Gln 
    930                 935                 940                 


Gly Gln Ala Asp Pro Val Val Ala Val Ala Arg Asp Gln Ser Ser Val 
945                 950                 955                 960 


Tyr Leu Lys Leu Leu Met His Glu Thr Gln Pro Pro Ser His Phe Ser 
                965                 970                 975     


Val Ser Thr Ile Thr Arg Ile Tyr Arg Gly Tyr Asn Leu Leu Pro Ser 
            980                 985                 990         


Ile Thr Asp Val Thr Met Glu Asn  Asn Leu Ser Arg Val  Ile Ala Ala 
        995                 1000                 1005             


Val Ser  His Glu Leu Ile Thr  Ser Thr Thr Arg Ala  Leu Thr Phe 
    1010                 1015                 1020             


Gly Cys  Cys Glu Ala Leu Cys  Leu Leu Ser Thr Ala  Phe Pro Val 
    1025                 1030                 1035             


Cys Ile  Trp Ser Leu Gly Trp  His Cys Gly Val Pro  Pro Leu Ser 
    1040                 1045                 1050             


Ala Ser  Asp Glu Ser Arg Lys  Ser Cys Thr Val Gly  Met Ala Thr 
    1055                 1060                 1065             


Met Ile  Leu Thr Leu Leu Ser  Ser Ala Trp Phe Pro  Leu Asp Leu 
    1070                 1075                 1080             


Ser Ala  His Gln Asp Ala Leu  Ile Leu Ala Gly Asn  Leu Leu Ala 
    1085                 1090                 1095             


Ala Ser  Ala Pro Lys Ser Leu  Arg Ser Ser Trp Ala  Ser Glu Glu 
    1100                 1105                 1110             


Glu Ala  Asn Pro Ala Ala Thr  Lys Gln Glu Glu Val  Trp Pro Ala 
    1115                 1120                 1125             


Leu Gly  Asp Arg Ala Leu Val  Pro Met Val Glu Gln  Leu Phe Ser 
    1130                 1135                 1140             


His Leu  Leu Lys Val Ile Asn  Ile Cys Ala His Val  Leu Asp Asp 
    1145                 1150                 1155             


Val Ala  Pro Gly Pro Ala Ile  Lys Ala Ala Leu Pro  Ser Leu Thr 
    1160                 1165                 1170             


Asn Pro  Pro Ser Leu Ser Pro  Ile Arg Arg Lys Gly  Lys Glu Lys 
    1175                 1180                 1185             


Glu Pro  Gly Glu Gln Ala Ser  Val Pro Leu Ser Pro  Lys Lys Gly 
    1190                 1195                 1200             


Ser Glu  Ala Ser Ala Ala Ser  Arg Gln Ser Asp Thr  Ser Gly Pro 
    1205                 1210                 1215             


Val Thr  Thr Ser Lys Ser Ser  Ser Leu Gly Ser Phe  Tyr His Leu 
    1220                 1225                 1230             


Pro Ser  Tyr Leu Lys Leu His  Asp Val Leu Lys Ala  Thr His Ala 
    1235                 1240                 1245             


Asn Tyr  Lys Val Thr Leu Asp  Leu Gln Asn Ser Thr  Glu Lys Phe 
    1250                 1255                 1260             


Gly Gly  Phe Leu Arg Ser Ala  Leu Asp Val Leu Ser  Gln Ile Leu 
    1265                 1270                 1275             


Glu Leu  Ala Thr Leu Gln Asp  Ile Gly Lys Cys Val  Glu Glu Ile 
    1280                 1285                 1290             


Leu Gly  Tyr Leu Lys Ser Cys  Phe Ser Arg Glu Pro  Met Met Ala 
    1295                 1300                 1305             


Thr Val  Cys Val Gln Gln Leu  Leu Lys Thr Leu Phe  Gly Thr Asn 
    1310                 1315                 1320             


Leu Ala  Ser Gln Phe Asp Gly  Leu Ser Ser Asn Pro  Ser Lys Ser 
    1325                 1330                 1335             


Gln Gly  Arg Ala Gln Arg Leu  Gly Ser Ser Ser Val  Arg Pro Gly 
    1340                 1345                 1350             


Leu Tyr  His Tyr Cys Phe Met  Ala Pro Tyr Thr His  Phe Thr Gln 
    1355                 1360                 1365             


Ala Leu  Ala Asp Ala Ser Leu  Arg Asn Met Val Gln  Ala Glu Gln 
    1370                 1375                 1380             


Glu Asn  Asp Thr Ser Gly Trp  Phe Asp Val Leu Gln  Lys Val Ser 
    1385                 1390                 1395             


Thr Gln  Leu Lys Thr Asn Leu  Thr Ser Val Thr Lys  Asn Arg Ala 
    1400                 1405                 1410             


Asp Lys  Asn Ala Ile His Asn  His Ile Arg Leu Phe  Glu Pro Leu 
    1415                 1420                 1425             


Val Ile  Lys Ala Leu Lys Gln  Tyr Thr Thr Thr Thr  Cys Val Gln 
    1430                 1435                 1440             


Leu Gln  Lys Gln Val Leu Asp  Leu Leu Ala Gln Leu  Val Gln Leu 
    1445                 1450                 1455             


Arg Val  Asn Tyr Cys Leu Leu  Asp Ser Asp Gln Val  Phe Ile Gly 
    1460                 1465                 1470             


Phe Val  Leu Lys Gln Phe Glu  Tyr Ile Glu Val Gly  Gln Phe Arg 
    1475                 1480                 1485             


Glu Ser  Glu Ala Ile Ile Pro  Asn Ile Phe Phe Phe  Leu Val Leu 
    1490                 1495                 1500             


Leu Ser  Tyr Glu Arg Tyr His  Ser Lys Gln Ile Ile  Gly Ile Pro 
    1505                 1510                 1515             


Lys Ile  Ile Gln Leu Cys Asp  Gly Ile Met Ala Ser  Gly Arg Lys 
    1520                 1525                 1530             


Ala Val  Thr His Ala Ile Pro  Ala Leu Gln Pro Ile  Val His Asp 
    1535                 1540                 1545             


Leu Phe  Val Leu Arg Gly Thr  Asn Lys Ala Asp Ala  Gly Lys Glu 
    1550                 1555                 1560             


Leu Glu  Thr Gln Lys Glu Val  Val Val Ser Met Leu  Leu Arg Leu 
    1565                 1570                 1575             


Ile Gln  Tyr His Gln Val Leu  Glu Met Phe Ile Leu  Val Leu Gln 
    1580                 1585                 1590             


Gln Cys  His Lys Glu Asn Glu  Asp Lys Trp Lys Arg  Leu Ser Arg 
    1595                 1600                 1605             


Gln Ile  Ala Asp Ile Ile Leu  Pro Met Leu Ala Lys  Gln Gln Met 
    1610                 1615                 1620             


His Ile  Asp Ser His Glu Ala  Leu Gly Val Leu Asn  Thr Leu Phe 
    1625                 1630                 1635             


Glu Ile  Leu Ala Pro Ser Ser  Leu Arg Pro Val Asp  Met Leu Leu 
    1640                 1645                 1650             


Arg Ser  Met Phe Val Thr Pro  Asn Thr Met Ala Ser  Val Ser Thr 
    1655                 1660                 1665             


Val Gln  Leu Trp Ile Ser Gly  Ile Leu Ala Ile Leu  Arg Val Leu 
    1670                 1675                 1680             


Ile Ser  Gln Ser Thr Glu Asp  Ile Val Leu Ser Arg  Ile Gln Glu 
    1685                 1690                 1695             


Leu Ser  Phe Ser Pro Tyr Leu  Ile Ser Cys Thr Val  Ile Asn Arg 
    1700                 1705                 1710             


Leu Arg  Asp Gly Asp Ser Thr  Ser Thr Leu Glu Glu  His Ser Glu 
    1715                 1720                 1725             


Gly Lys  Gln Ile Lys Asn Leu  Pro Glu Glu Thr Phe  Ser Arg Phe 
    1730                 1735                 1740             


Leu Leu  Gln Leu Val Gly Ile  Leu Leu Glu Asp Ile  Val Thr Lys 
    1745                 1750                 1755             


Gln Leu  Lys Val Glu Met Ser  Glu Gln Gln His Thr  Phe Tyr Cys 
    1760                 1765                 1770             


Gln Glu  Leu Gly Thr Leu Leu  Met Cys Leu Ile His  Ile Phe Lys 
    1775                 1780                 1785             


Ser Gly  Met Phe Arg Arg Ile  Thr Ala Ala Ala Thr  Arg Leu Phe 
    1790                 1795                 1800             


Arg Ser  Asp Gly Cys Gly Gly  Ser Phe Tyr Thr Leu  Asp Ser Leu 
    1805                 1810                 1815             


Asn Leu  Arg Ala Arg Ser Met  Ile Thr Thr His Pro  Ala Leu Val 
    1820                 1825                 1830             


Leu Leu  Trp Cys Gln Ile Leu  Leu Leu Val Asn His  Thr Asp Tyr 
    1835                 1840                 1845             


Arg Trp  Trp Ala Glu Val Gln  Gln Thr Pro Lys Arg  His Ser Leu 
    1850                 1855                 1860             


Ser Ser  Thr Lys Leu Leu Ser  Pro Gln Met Ser Gly  Glu Glu Glu 
    1865                 1870                 1875             


Asp Ser  Asp Leu Ala Ala Lys  Leu Gly Met Cys Asn  Arg Glu Ile 
    1880                 1885                 1890             


Val Arg  Arg Gly Ala Leu Ile  Leu Phe Cys Asp Tyr  Val Cys Gln 
    1895                 1900                 1905             


Asn Leu  His Asp Ser Glu His  Leu Thr Trp Leu Ile  Val Asn His 
    1910                 1915                 1920             


Ile Gln  Asp Leu Ile Ser Leu  Ser His Glu Pro Pro  Val Gln Asp 
    1925                 1930                 1935             


Phe Ile  Ser Ala Val His Arg  Asn Ser Ala Ala Ser  Gly Leu Phe 
    1940                 1945                 1950             


Ile Gln  Ala Ile Gln Ser Arg  Cys Glu Asn Leu Ser  Thr Pro Thr 
    1955                 1960                 1965             


Met Leu  Lys Lys Thr Leu Gln  Cys Leu Glu Gly Ile  His Leu Ser 
    1970                 1975                 1980             


Gln Ser  Gly Ala Val Leu Thr  Leu Tyr Val Asp Arg  Leu Leu Cys 
    1985                 1990                 1995             


Thr Pro  Phe Arg Val Leu Ala  Arg Met Val Asp Ile  Leu Ala Cys 
    2000                 2005                 2010             


Arg Arg  Val Glu Met Leu Leu  Ala Ala Asn Leu Gln  Ser Ser Met 
    2015                 2020                 2025             


Ala Gln  Leu Pro Met Glu Glu  Leu Asn Arg Ile Gln  Glu Tyr Leu 
    2030                 2035                 2040             


Gln Ser  Ser Gly Leu Ala Gln  Arg His Gln Arg Leu  Tyr Ser Leu 
    2045                 2050                 2055             


Leu Asp  Arg Phe Arg Leu Ser  Thr Met Gln Asp Ser  Leu Ser Pro 
    2060                 2065                 2070             


Ser Pro  Pro Val Ser Ser His  Pro Leu Asp Gly Asp  Gly His Val 
    2075                 2080                 2085             


Ser Leu  Glu Thr Val Ser Pro  Asp Lys Asp Trp Tyr  Val His Leu 
    2090                 2095                 2100             


Val Lys  Ser Gln Cys Trp Thr  Arg Ser Asp Ser Ala  Leu Leu Glu 
    2105                 2110                 2115             


Gly Ala  Glu Leu Val Asn Arg  Ile Pro Ala Glu Asp  Met Asn Ala 
    2120                 2125                 2130             


Phe Met  Met Asn Ser Glu Phe  Asn Leu Ser Leu Leu  Ala Pro Cys 
    2135                 2140                 2145             


Leu Ser  Leu Gly Met Ser Glu  Ile Ser Gly Gly Gln  Lys Ser Ala 
    2150                 2155                 2160             


Leu Phe  Glu Ala Ala Arg Glu  Val Thr Leu Ala Arg  Val Ser Gly 
    2165                 2170                 2175             


Thr Val  Gln Gln Leu Pro Ala  Val His His Val Phe  Gln Pro Glu 
    2180                 2185                 2190             


Leu Pro  Ala Glu Pro Ala Ala  Tyr Trp Ser Lys Leu  Asn Asp Leu 
    2195                 2200                 2205             


Phe Gly  Asp Ala Ala Leu Tyr  Gln Ser Leu Pro Thr  Leu Ala Arg 
    2210                 2215                 2220             


Ala Leu  Ala Gln Tyr Leu Val  Val Val Ser Lys Leu  Pro Ser His 
    2225                 2230                 2235             


Leu His  Leu Pro Pro Glu Lys  Glu Lys Asp Ile Val  Lys Phe Val 
    2240                 2245                 2250             


Val Ala  Thr Leu Glu Ala Leu  Ser Trp His Leu Ile  His Glu Gln 
    2255                 2260                 2265             


Ile Pro  Leu Ser Leu Asp Leu  Gln Ala Gly Leu Asp  Cys Cys Cys 
    2270                 2275                 2280             


Leu Ala  Leu Gln Leu Pro Gly  Leu Trp Ser Val Val  Ser Ser Thr 
    2285                 2290                 2295             


Glu Phe  Val Thr His Ala Cys  Ser Leu Ile Tyr Cys  Val His Phe 
    2300                 2305                 2310             


Ile Leu  Glu Ala Val Ala Val  Gln Pro Gly Glu Gln  Leu Leu Ser 
    2315                 2320                 2325             


Pro Glu  Arg Arg Thr Asn Thr  Pro Lys Ala Ile Ser  Glu Glu Glu 
    2330                 2335                 2340             


Glu Glu  Val Asp Pro Asn Thr  Gln Asn Pro Lys Tyr  Ile Thr Ala 
    2345                 2350                 2355             


Ala Cys  Glu Met Val Ala Glu  Met Val Glu Ser Leu  Gln Ser Val 
    2360                 2365                 2370             


Leu Ala  Leu Gly His Lys Arg  Asn Ser Gly Val Pro  Ala Phe Leu 
    2375                 2380                 2385             


Thr Pro  Leu Leu Arg Asn Ile  Ile Ile Ser Leu Ala  Arg Leu Pro 
    2390                 2395                 2400             


Leu Val  Asn Ser Tyr Thr Arg  Val Pro Pro Leu Val  Trp Lys Leu 
    2405                 2410                 2415             


Gly Trp  Ser Pro Lys Pro Gly  Gly Asp Phe Gly Thr  Ala Phe Pro 
    2420                 2425                 2430             


Glu Ile  Pro Val Glu Phe Leu  Gln Glu Lys Glu Val  Phe Lys Glu 
    2435                 2440                 2445             


Phe Ile  Tyr Arg Ile Asn Thr  Leu Gly Trp Thr Ser  Arg Thr Gln 
    2450                 2455                 2460             


Phe Glu  Glu Thr Trp Ala Thr  Leu Leu Gly Val Leu  Val Thr Gln 
    2465                 2470                 2475             


Pro Leu  Val Met Glu Gln Glu  Glu Ser Pro Pro Glu  Glu Asp Thr 
    2480                 2485                 2490             


Glu Arg  Thr Gln Ile Asn Val  Leu Ala Val Gln Ala  Ile Thr Ser 
    2495                 2500                 2505             


Leu Val  Leu Ser Ala Met Thr  Val Pro Val Ala Gly  Asn Pro Ala 
    2510                 2515                 2520             


Val Ser  Cys Leu Glu Gln Gln  Pro Arg Asn Lys Pro  Leu Lys Ala 
    2525                 2530                 2535             


Leu Asp  Thr Arg Phe Gly Arg  Lys Leu Ser Ile Ile  Arg Gly Ile 
    2540                 2545                 2550             


Val Glu  Gln Glu Ile Gln Ala  Met Val Ser Lys Arg  Glu Asn Ile 
    2555                 2560                 2565             


Ala Thr  His His Leu Tyr Gln  Ala Trp Asp Pro Val  Pro Ser Leu 
    2570                 2575                 2580             


Ser Pro  Ala Thr Thr Gly Ala  Leu Ile Ser His Glu  Lys Leu Leu 
    2585                 2590                 2595             


Leu Gln  Ile Asn Pro Glu Arg  Glu Leu Gly Ser Met  Ser Tyr Lys 
    2600                 2605                 2610             


Leu Gly  Gln Val Ser Ile His  Ser Val Trp Leu Gly  Asn Ser Ile 
    2615                 2620                 2625             


Thr Pro  Leu Arg Glu Glu Glu  Trp Asp Glu Glu Glu  Glu Glu Glu 
    2630                 2635                 2640             


Ala Asp  Ala Pro Ala Pro Ser  Ser Pro Pro Thr Ser  Pro Val Asn 
    2645                 2650                 2655             


Ser Arg  Lys His Arg Ala Gly  Val Asp Ile His Ser  Cys Ser Gln 
    2660                 2665                 2670             


Phe Leu  Leu Glu Leu Tyr Ser  Arg Trp Ile Leu Pro  Ser Ser Ser 
    2675                 2680                 2685             


Ala Arg  Arg Thr Pro Ala Ile  Leu Ile Ser Glu Val  Val Arg Ser 
    2690                 2695                 2700             


Leu Leu  Val Val Ser Asp Leu  Phe Thr Glu Arg Asn  Gln Phe Glu 
    2705                 2710                 2715             


Leu Met  Tyr Val Thr Leu Thr  Glu Leu Arg Arg Val  His Pro Ser 
    2720                 2725                 2730             


Glu Asp  Glu Ile Leu Ala Gln  Tyr Leu Val Pro Ala  Thr Cys Lys 
    2735                 2740                 2745             


Ala Ala  Ala Val Leu Gly Met  Asp Lys Ala Val Ala  Glu Pro Val 
    2750                 2755                 2760             


Ser Arg  Leu Leu Glu Ser Thr  Leu Arg Ser Ser His  Leu Pro Ser 
    2765                 2770                 2775             


Arg Val  Gly Ala Leu His Gly  Val Leu Tyr Val Leu  Glu Cys Asp 
    2780                 2785                 2790             


Leu Leu  Asp Asp Thr Ala Lys  Gln Leu Ile Pro Val  Ile Ser Asp 
    2795                 2800                 2805             


Tyr Leu  Leu Ser Asn Leu Lys  Gly Ile Ala His Cys  Val Asn Ile 
    2810                 2815                 2820             


His Ser  Gln Gln His Val Leu  Val Met Cys Ala Thr  Ala Phe Tyr 
    2825                 2830                 2835             


Leu Ile  Glu Asn Tyr Pro Leu  Asp Val Gly Pro Glu  Phe Ser Ala 
    2840                 2845                 2850             


Ser Ile  Ile Gln Met Cys Gly  Val Met Leu Ser Gly  Ser Glu Glu 
    2855                 2860                 2865             


Ser Thr  Pro Ser Ile Ile Tyr  His Cys Ala Leu Arg  Gly Leu Glu 
    2870                 2875                 2880             


Arg Leu  Leu Leu Ser Glu Gln  Leu Ser Arg Leu Asp  Ala Glu Ser 
    2885                 2890                 2895             


Leu Val  Lys Leu Ser Val Asp  Arg Val Asn Val His  Ser Pro His 
    2900                 2905                 2910             


Arg Ala  Met Ala Ala Leu Gly  Leu Met Leu Thr Cys  Met Tyr Thr 
    2915                 2920                 2925             


Gly Lys  Glu Lys Val Ser Pro  Gly Arg Thr Ser Asp  Pro Asn Pro 
    2930                 2935                 2940             


Ala Ala  Pro Asp Ser Glu Ser  Val Ile Val Ala Met  Glu Arg Val 
    2945                 2950                 2955             


Ser Val  Leu Phe Asp Arg Ile  Arg Lys Gly Phe Pro  Cys Glu Ala 
    2960                 2965                 2970             


Arg Val  Val Ala Arg Ile Leu  Pro Gln Phe Leu Asp  Asp Phe Phe 
    2975                 2980                 2985             


Pro Pro  Gln Asp Ile Met Asn  Lys Val Ile Gly Glu  Phe Leu Ser 
    2990                 2995                 3000             


Asn Gln  Gln Pro Tyr Pro Gln  Phe Met Ala Thr Val  Val Tyr Lys 
    3005                 3010                 3015             


Val Phe  Gln Thr Leu His Ser  Thr Gly Gln Ser Ser  Met Val Arg 
    3020                 3025                 3030             


Asp Trp  Val Met Leu Ser Leu  Ser Asn Phe Thr Gln  Arg Ala Pro 
    3035                 3040                 3045             


Val Ala  Met Ala Thr Trp Ser  Leu Ser Cys Phe Phe  Val Ser Ala 
    3050                 3055                 3060             


Ser Thr  Ser Pro Trp Val Ala  Ala Ile Leu Pro His  Val Ile Ser 
    3065                 3070                 3075             


Arg Met  Gly Lys Leu Glu Gln  Val Asp Val Asn Leu  Phe Cys Leu 
    3080                 3085                 3090             


Val Ala  Thr Asp Phe Tyr Arg  His Gln Ile Glu Glu  Glu Leu Asp 
    3095                 3100                 3105             


Arg Arg  Ala Phe Gln Ser Val  Leu Glu Val Val Ala  Ala Pro Gly 
    3110                 3115                 3120             


Ser Pro  Tyr His Arg Leu Leu  Thr Cys Leu Arg Asn  Val His Lys 
    3125                 3130                 3135             


Val Thr  Thr Cys 
    3140         

<210>  1876
<211>  13646
<212>  DNA
<213>  Homo sapiens

<400>  1876
ttgctgtgtg aggcagaacc tgcgggggca ggggcgggct ggttccctgg ccagccattg     60

gcagagtccg caggctaggg ctgtcaatca tgctggccgg cgtggccccg cctccgccgg    120

cgcggccccg cctccgccgg cgcagcgtct gggacgcaag gcgccgtggg ggctgccggg    180

acgggtccaa gatggacggc cgctcaggtt ctgcttttac ctgcggccca gagccccatt    240

cattgccccg gtgctgagcg gcgccgcgag tcggcccgag gcctccgggg actgccgtgc    300

cgggcgggag accgccatgg cgaccctgga aaagctgatg aaggccttcg agtccctcaa    360

gtccttccag cagcagcagc agcagcagca gcagcagcag cagcagcagc agcagcagca    420

gcagcaacag ccgccaccgc cgccgccgcc gccgccgcct cctcagcttc ctcagccgcc    480

gccgcaggca cagccgctgc tgcctcagcc gcagccgccc ccgccgccgc ccccgccgcc    540

acccggcccg gctgtggctg aggagccgct gcaccgacca aagaaagaac tttcagctac    600

caagaaagac cgtgtgaatc attgtctgac aatatgtgaa aacatagtgg cacagtctgt    660

cagaaattct ccagaatttc agaaacttct gggcatcgct atggaacttt ttctgctgtg    720

cagtgatgac gcagagtcag atgtcaggat ggtggctgac gaatgcctca acaaagttat    780

caaagctttg atggattcta atcttccaag gttacagctc gagctctata aggaaattaa    840

aaagaatggt gcccctcgga gtttgcgtgc tgccctgtgg aggtttgctg agctggctca    900

cctggttcgg cctcagaaat gcaggcctta cctggtgaac cttctgccgt gcctgactcg    960

aacaagcaag agacccgaag aatcagtcca ggagaccttg gctgcagctg ttcccaaaat   1020

tatggcttct tttggcaatt ttgcaaatga caatgaaatt aaggttttgt taaaggcctt   1080

catagcgaac ctgaagtcaa gctcccccac cattcggcgg acagcggctg gatcagcagt   1140

gagcatctgc cagcactcaa gaaggacaca atatttctat agttggctac taaatgtgct   1200

cttaggctta ctcgttcctg tcgaggatga acactccact ctgctgattc ttggcgtgct   1260

gctcaccctg aggtatttgg tgcccttgct gcagcagcag gtcaaggaca caagcctgaa   1320

aggcagcttc ggagtgacaa ggaaagaaat ggaagtctct ccttctgcag agcagcttgt   1380

ccaggtttat gaactgacgt tacatcatac acagcaccaa gaccacaatg ttgtgaccgg   1440

agccctggag ctgttgcagc agctcttcag aacgcctcca cccgagcttc tgcaaaccct   1500

gaccgcagtc gggggcattg ggcagctcac cgctgctaag gaggagtctg gtggccgaag   1560

ccgtagtggg agtattgtgg aacttatagc tggagggggt tcctcatgca gccctgtcct   1620

ttcaagaaaa caaaaaggca aagtgctctt aggagaagaa gaagccttgg aggatgactc   1680

tgaatcgaga tcggatgtca gcagctctgc cttaacagcc tcagtgaagg atgagatcag   1740

tggagagctg gctgcttctt caggggtttc cactccaggg tcagcaggtc atgacatcat   1800

cacagaacag ccacggtcac agcacacact gcaggcggac tcagtggatc tggccagctg   1860

tgacttgaca agctctgcca ctgatgggga tgaggaggat atcttgagcc acagctccag   1920

ccaggtcagc gccgtcccat ctgaccctgc catggacctg aatgatggga cccaggcctc   1980

gtcgcccatc agcgacagct cccagaccac caccgaaggg cctgattcag ctgttacccc   2040

ttcagacagt tctgaaattg tgttagacgg taccgacaac cagtatttgg gcctgcagat   2100

tggacagccc caggatgaag atgaggaagc cacaggtatt cttcctgatg aagcctcgga   2160

ggccttcagg aactcttcca tggcccttca acaggcacat ttattgaaaa acatgagtca   2220

ctgcaggcag ccttctgaca gcagtgttga taaatttgtg ttgagagatg aagctactga   2280

accgggtgat caagaaaaca agccttgccg catcaaaggt gacattggac agtccactga   2340

tgatgactct gcacctcttg tccattgtgt ccgcctttta tctgcttcgt ttttgctaac   2400

agggggaaaa aatgtgctgg ttccggacag ggatgtgagg gtcagcgtga aggccctggc   2460

cctcagctgt gtgggagcag ctgtggccct ccacccggaa tctttcttca gcaaactcta   2520

taaagttcct cttgacacca cggaataccc tgaggaacag tatgtctcag acatcttgaa   2580

ctacatcgat catggagacc cacaggttcg aggagccact gccattctct gtgggaccct   2640

catctgctcc atcctcagca ggtcccgctt ccacgtggga gattggatgg gcaccattag   2700

aaccctcaca ggaaatacat tttctttggc ggattgcatt cctttgctgc ggaaaacact   2760

gaaggatgag tcttctgtta cttgcaagtt agcttgtaca gctgtgagga actgtgtcat   2820

gagtctctgc agcagcagct acagtgagtt aggactgcag ctgatcatcg atgtgctgac   2880

tctgaggaac agttcctatt ggctggtgag gacagagctt ctggaaaccc ttgcagagat   2940

tgacttcagg ctggtgagct ttttggaggc aaaagcagaa aacttacaca gaggggctca   3000

tcattataca gggcttttaa aactgcaaga acgagtgctc aataatgttg tcatccattt   3060

gcttggagat gaagacccca gggtgcgaca tgttgccgca gcatcactaa ttaggcttgt   3120

cccaaagctg ttttataaat gtgaccaagg acaagctgat ccagtagtgg ccgtggcaag   3180

agatcaaagc agtgtttacc tgaaacttct catgcatgag acgcagcctc catctcattt   3240

ctccgtcagc acaataacca gaatatatag aggctataac ctactaccaa gcataacaga   3300

cgtcactatg gaaaataacc tttcaagagt tattgcagca gtttctcatg aactaatcac   3360

atcaaccacc agagcactca catttggatg ctgtgaagct ttgtgtcttc tttccactgc   3420

cttcccagtt tgcatttgga gtttaggttg gcactgtgga gtgcctccac tgagtgcctc   3480

agatgagtct aggaagagct gtaccgttgg gatggccaca atgattctga ccctgctctc   3540

gtcagcttgg ttcccattgg atctctcagc ccatcaagat gctttgattt tggccggaaa   3600

cttgcttgca gccagtgctc ccaaatctct gagaagttca tgggcctctg aagaagaagc   3660

caacccagca gccaccaagc aagaggaggt ctggccagcc ctgggggacc gggccctggt   3720

gcccatggtg gagcagctct tctctcacct gctgaaggtg attaacattt gtgcccacgt   3780

cctggatgac gtggctcctg gacccgcaat aaaggcagcc ttgccttctc taacaaaccc   3840

cccttctcta agtcccatcc gacgaaaggg gaaggagaaa gaaccaggag aacaagcatc   3900

tgtaccgttg agtcccaaga aaggcagtga ggccagtgca gcttctagac aatctgatac   3960

ctcaggtcct gttacaacaa gtaaatcctc atcactgggg agtttctatc atcttccttc   4020

atacctcaaa ctgcatgatg tcctgaaagc tacacacgct aactacaagg tcacgctgga   4080

tcttcagaac agcacggaaa agtttggagg gtttctccgc tcagccttgg atgttctttc   4140

tcagatacta gagctggcca cactgcagga cattgggaag tgtgttgaag agatcctagg   4200

atacctgaaa tcctgcttta gtcgagaacc aatgatggca actgtttgtg ttcaacaatt   4260

gttgaagact ctctttggca caaacttggc ctcccagttt gatggcttat cttccaaccc   4320

cagcaagtca caaggccgag cacagcgcct tggctcctcc agtgtgaggc caggcttgta   4380

ccactactgc ttcatggccc cgtacaccca cttcacccag gccctcgctg acgccagcct   4440

gaggaacatg gtgcaggcgg agcaggagaa cgacacctcg ggatggtttg atgtcctcca   4500

gaaagtgtct acccagttga agacaaacct cacgagtgtc acaaagaacc gtgcagataa   4560

gaatgctatt cataatcaca ttcgtttgtt tgaacctctt gttataaaag ctttaaaaca   4620

gtacacgact acaacatgtg tgcagttaca gaagcaggtt ttagatttgc tggcgcagct   4680

ggttcagtta cgggttaatt actgtcttct ggattcagat caggtgttta ttggctttgt   4740

attgaaacag tttgaataca ttgaagtggg ccagttcagg gaatcagagg caatcattcc   4800

aaacatcttt ttcttcttgg tattactatc ttatgaacgc tatcattcaa aacagatcat   4860

tggaattcct aaaatcattc agctctgtga tggcatcatg gccagtggaa ggaaggctgt   4920

gacacatgcc ataccggctc tgcagcccat agtccacgac ctctttgtat taagaggaac   4980

aaataaagct gatgcaggaa aagagcttga aacccaaaaa gaggtggtgg tgtcaatgtt   5040

actgagactc atccagtacc atcaggtgtt ggagatgttc attcttgtcc tgcagcagtg   5100

ccacaaggag aatgaagaca agtggaagcg actgtctcga cagatagctg acatcatcct   5160

cccaatgtta gccaaacagc agatgcacat tgactctcat gaagcccttg gagtgttaaa   5220

tacattattt gagattttgg ccccttcctc cctccgtccg gtagacatgc ttttacggag   5280

tatgttcgtc actccaaaca caatggcgtc cgtgagcact gttcaactgt ggatatcggg   5340

aattctggcc attttgaggg ttctgatttc ccagtcaact gaagatattg ttctttctcg   5400

tattcaggag ctctccttct ctccgtattt aatctcctgt acagtaatta ataggttaag   5460

agatggggac agtacttcaa cgctagaaga acacagtgaa gggaaacaaa taaagaattt   5520

gccagaagaa acattttcaa ggtttctatt acaactggtt ggtattcttt tagaagacat   5580

tgttacaaaa cagctgaagg tggaaatgag tgagcagcaa catactttct attgccagga   5640

actaggcaca ctgctaatgt gtctgatcca catcttcaag tctggaatgt tccggagaat   5700

cacagcagct gccactaggc tgttccgcag tgatggctgt ggcggcagtt tctacaccct   5760

ggacagcttg aacttgcggg ctcgttccat gatcaccacc cacccggccc tggtgctgct   5820

ctggtgtcag atactgctgc ttgtcaacca caccgactac cgctggtggg cagaagtgca   5880

gcagaccccg aaaagacaca gtctgtccag cacaaagtta cttagtcccc agatgtctgg   5940

agaagaggag gattctgact tggcagccaa acttggaatg tgcaatagag aaatagtacg   6000

aagaggggct ctcattctct tctgtgatta tgtctgtcag aacctccatg actccgagca   6060

cttaacgtgg ctcattgtaa atcacattca agatctgatc agcctttccc acgagcctcc   6120

agtacaggac ttcatcagtg ccgttcatcg gaactctgct gccagcggcc tgttcatcca   6180

ggcaattcag tctcgttgtg aaaacctttc aactccaacc atgctgaaga aaactcttca   6240

gtgcttggag gggatccatc tcagccagtc gggagctgtg ctcacgctgt atgtggacag   6300

gcttctgtgc acccctttcc gtgtgctggc tcgcatggtc gacatccttg cttgtcgccg   6360

ggtagaaatg cttctggctg caaatttaca gagcagcatg gcccagttgc caatggaaga   6420

actcaacaga atccaggaat accttcagag cagcgggctc gctcagagac accaaaggct   6480

ctattccctg ctggacaggt ttcgtctctc caccatgcaa gactcactta gtccctctcc   6540

tccagtctct tcccacccgc tggacgggga tgggcacgtg tcactggaaa cagtgagtcc   6600

ggacaaagac tggtacgttc atcttgtcaa atcccagtgt tggaccaggt cagattctgc   6660

actgctggaa ggtgcagagc tggtgaatcg gattcctgct gaagatatga atgccttcat   6720

gatgaactcg gagttcaacc taagcctgct agctccatgc ttaagcctag ggatgagtga   6780

aatttctggt ggccagaaga gtgccctttt tgaagcagcc cgtgaggtga ctctggcccg   6840

tgtgagcggc accgtgcagc agctccctgc tgtccatcat gtcttccagc ccgagctgcc   6900

tgcagagccg gcggcctact ggagcaagtt gaatgatctg tttggggatg ctgcactgta   6960

tcagtccctg cccactctgg cccgggccct ggcacagtac ctggtggtgg tctccaaact   7020

gcccagtcat ttgcaccttc ctcctgagaa agagaaggac attgtgaaat tcgtggtggc   7080

aacccttgag gccctgtcct ggcatttgat ccatgagcag atcccgctga gtctggatct   7140

ccaggcaggg ctggactgct gctgcctggc cctgcagctg cctggcctct ggagcgtggt   7200

ctcctccaca gagtttgtga cccacgcctg ctccctcatc tactgtgtgc acttcatcct   7260

ggaggccgtt gcagtgcagc ctggagagca gcttcttagt ccagaaagaa ggacaaatac   7320

cccaaaagcc atcagcgagg aggaggagga agtagatcca aacacacaga atcctaagta   7380

tatcactgca gcctgtgaga tggtggcaga aatggtggag tctctgcagt cggtgttggc   7440

cttgggtcat aaaaggaata gcggcgtgcc ggcgtttctc acgccattgc taaggaacat   7500

catcatcagc ctggcccgcc tgccccttgt caacagctac acacgtgtgc ccccactggt   7560

gtggaagctt ggatggtcac ccaaaccggg aggggatttt ggcacagcat tccctgagat   7620

ccccgtggag ttcctccagg aaaaggaagt ctttaaggag ttcatctacc gcatcaacac   7680

actaggctgg accagtcgta ctcagtttga agaaacttgg gccaccctcc ttggtgtcct   7740

ggtgacgcag cccctcgtga tggagcagga ggagagccca ccagaagaag acacagagag   7800

gacccagatc aacgtcctgg ccgtgcaggc catcacctca ctggtgctca gtgcaatgac   7860

tgtgcctgtg gccggcaacc cagctgtaag ctgcttggag cagcagcccc ggaacaagcc   7920

tctgaaagct ctcgacacca ggtttgggag gaagctgagc attatcagag ggattgtgga   7980

gcaagagatt caagcaatgg tttcaaagag agagaatatt gccacccatc atttatatca   8040

ggcatgggat cctgtccctt ctctgtctcc ggctactaca ggtgccctca tcagccacga   8100

gaagctgctg ctacagatca accccgagcg ggagctgggg agcatgagct acaaactcgg   8160

ccaggtgtcc atacactccg tgtggctggg gaacagcatc acacccctga gggaggagga   8220

atgggacgag gaagaggagg aggaggccga cgcccctgca ccttcgtcac cacccacgtc   8280

tccagtcaac tccaggaaac accgggctgg agttgacatc cactcctgtt cgcagttttt   8340

gcttgagttg tacagccgct ggatcctgcc gtccagctca gccaggagga ccccggccat   8400

cctgatcagt gaggtggtca gatcccttct agtggtctca gacttgttca ccgagcgcaa   8460

ccagtttgag ctgatgtatg tgacgctgac agaactgcga agggtgcacc cttcagaaga   8520

cgagatcctc gctcagtacc tggtgcctgc cacctgcaag gcagctgccg tccttgggat   8580

ggacaaggcc gtggcggagc ctgtcagccg cctgctggag agcacgctca ggagcagcca   8640

cctgcccagc agggttggag ccctgcacgg cgtcctctat gtgctggagt gcgacctgct   8700

ggacgacact gccaagcagc tcatcccggt catcagcgac tatctcctct ccaacctgaa   8760

agggatcgcc cactgcgtga acattcacag ccagcagcac gtactggtca tgtgtgccac   8820

tgcgttttac ctcattgaga actatcctct ggacgtaggg ccggaatttt cagcatcaat   8880

aatacagatg tgtggggtga tgctgtctgg aagtgaggag tccaccccct ccatcattta   8940

ccactgtgcc ctcagaggcc tggagcgcct cctgctctct gagcagctct cccgcctgga   9000

tgcagaatcg ctggtcaagc tgagtgtgga cagagtgaac gtgcacagcc cgcaccgggc   9060

catggcggct ctgggcctga tgctcacctg catgtacaca ggaaaggaga aagtcagtcc   9120

gggtagaact tcagacccta atcctgcagc ccccgacagc gagtcagtga ttgttgctat   9180

ggagcgggta tctgttcttt ttgataggat caggaaaggc tttccttgtg aagccagagt   9240

ggtggccagg atcctgcccc agtttctaga cgacttcttc ccaccccagg acatcatgaa   9300

caaagtcatc ggagagtttc tgtccaacca gcagccatac ccccagttca tggccaccgt   9360

ggtgtataag gtgtttcaga ctctgcacag caccgggcag tcgtccatgg tccgggactg   9420

ggtcatgctg tccctctcca acttcacgca gagggccccg gtcgccatgg ccacgtggag   9480

cctctcctgc ttctttgtca gcgcgtccac cagcccgtgg gtcgcggcga tcctcccaca   9540

tgtcatcagc aggatgggca agctggagca ggtggacgtg aaccttttct gcctggtcgc   9600

cacagacttc tacagacacc agatagagga ggagctcgac cgcagggcct tccagtctgt   9660

gcttgaggtg gttgcagccc caggaagccc atatcaccgg ctgctgactt gtttacgaaa   9720

tgtccacaag gtcaccacct gctgagcgcc atggtgggag agactgtgag gcggcagctg   9780

gggccggagc ctttggaagt ctgcgccctt gtgccctgcc tccaccgagc cagcttggtc   9840

cctatgggct tccgcacatg ccgcgggcgg ccaggcaacg tgcgtgtctc tgccatgtgg   9900

cagaagtgct ctttgtggca gtggccaggc agggagtgtc tgcagtcctg gtggggctga   9960

gcctgaggcc ttccagaaag caggagcagc tgtgctgcac cccatgtggg tgaccaggtc  10020

ctttctcctg atagtcacct gctggttgtt gccaggttgc agctgctctt gcatctgggc  10080

cagaagtcct ccctcctgca ggctggctgt tggcccctct gctgtcctgc agtagaaggt  10140

gccgtgagca ggctttggga acactggcct gggtctccct ggtggggtgt gcatgccacg  10200

ccccgtgtct ggatgcacag atgccatggc ctgtgctggg ccagtggctg ggggtgctag  10260

acacccggca ccattctccc ttctctcttt tcttctcagg atttaaaatt taattatatc  10320

agtaaagaga ttaattttaa cgtaactctt tctatgcccg tgtaaagtat gtgaatcgca  10380

aggcctgtgc tgcatgcgac agcgtccggg gtggtggaca gggcccccgg ccacgctccc  10440

tctcctgtag ccactggcat agccctcctg agcacccgct gacatttccg ttgtacatgt  10500

tcctgtttat gcattcacaa ggtgactggg atgtagagag gcgttagtgg gcaggtggcc  10560

acagcaggac tgaggacagg cccccattat cctaggggtg cgctcacctg cagcccctcc  10620

tcctcgggca cagacgactg tcgttctcca cccaccagtc agggacagca gcctccctgt  10680

cactcagctg agaaggccag ccctccctgg ctgtgagcag cctccactgt gtccagagac  10740

atgggcctcc cactcctgtt ccttgctagc cctggggtgg cgtctgccta ggagctggct  10800

ggcaggtgtt gggacctgct gctccatgga tgcatgccct aagagtgtca ctgagctgtg  10860

ttttgtctga gcctctctcg gtcaacagca aagcttggtg tcttggcact gttagtgaca  10920

gagcccagca tcccttctgc ccccgttcca gctgacatct tgcacggtga ccccttttag  10980

tcaggagagt gcagatctgt gctcatcgga gactgcccca cggccctgtc agagccgcca  11040

ctcctatccc caggccaggt ccctggacca gcctcctgtt tgcaggccca gaggagccaa  11100

gtcattaaaa tggaagtgga ttctggatgg ccgggctgct gctgatgtag gagctggatt  11160

tgggagctct gcttgccgac tggctgtgag acgaggcagg ggctctgctt cctcagccct  11220

agaggcgagc caggcaaggt tggcgactgt catgtggctt ggtttggtca tgcccgtcga  11280

tgttttgggt attgaatgtg gtaagtggag gaaatgttgg aactctgtgc aggtgctgcc  11340

ttgagacccc caagcttcca cctgtccctc tcctatgtgg cagctgggga gcagctgaga  11400

tgtggacttg tatgctgccc acatacgtga gggggagctg aaagggagcc cctcctctga  11460

gcagcctctg ccaggcctgt atgaggcttt tcccaccagc tcccaacaga ggcctccccc  11520

agccaggacc acctcgtcct cgtggcgggg cagcaggagc ggtagaaagg ggtccgatgt  11580

ttgaggaggc ccttaaggga agctactgaa ttataacacg taagaaaatc accattccgt  11640

attggttggg ggctcctgtt tctcatccta gctttttcct ggaaagcccg ctagaaggtt  11700

tgggaacgag gggaaagttc tcagaactgt tggctgctcc ccacccgcct cccgcctccc  11760

ccgcaggtta tgtcagcagc tctgagacag cagtatcaca ggccagatgt tgttcctggc  11820

tagatgttta catttgtaag aaataacact gtgaatgtaa aacagagcca ttcccttgga  11880

atgcatatcg ctgggctcaa catagagttt gtcttcctct tgtttacgac gtgatctaaa  11940

ccagtcctta gcaaggggct cagaacaccc cgctctggca gtaggtgtcc cccaccccca  12000

aagacctgcc tgtgtgctcc ggagatgaat atgagctcat tagtaaaaat gacttcaccc  12060

acgcatatac ataaagtatc catgcatgtg catatagaca catctataat tttacacaca  12120

cacctctcaa gacggagatg catggcctct aagagtgccc gtgtcggttc ttcctggaag  12180

ttgactttcc ttagacccgc caggtcaagt tagccgcgtg acggacatcc aggcgtggga  12240

cgtggtcagg gcagggctca ttcattgccc actaggatcc cactggcgaa gatggtctcc  12300

atatcagctc tctgcagaag ggaggaagac tttatcatgt tcctaaaaat ctgtggcaag  12360

cacccatcgt attatccaaa ttttgttgca aatgtgatta atttggttgt caagttttgg  12420

gggtgggctg tggggagatt gcttttgttt tcctgctggt aatatcggga aagattttaa  12480

tgaaaccagg gtagaattgt ttggcaatgc actgaagcgt gtttctttcc caaaatgtgc  12540

ctcccttccg ctgcgggccc agctgagtct atgtaggtga tgtttccagc tgccaagtgc  12600

tctttgttac tgtccaccct catttctgcc agcgcatgtg tcctttcaag gggaaaatgt  12660

gaagctgaac cccctccaga cacccagaat gtagcatctg agaaggccct gtgccctaaa  12720

ggacacccct cgcccccatc ttcatggagg gggtcatttc agagccctcg gagccaatga  12780

acagctcctc ctcttggagc tgagatgagc cccacgtgga gctcgggacg gatagtagac  12840

agcaataact cggtgtgtgg ccgcctggca ggtggaactt cctcccgttg cggggtggag  12900

tgaggttagt tctgtgtgtc tggtgggtgg agtcaggctt ctcttgctac ctgtgagcat  12960

ccttcccagc agacatcctc atcgggcttt gtccctcccc cgcttcctcc ctctgcgggg  13020

aggacccggg accacagctg ctggccaggg tagacttgga gctgtcctcc agaggggtca  13080

cgtgtaggag tgagaagaag gaagatcttg agagctgctg agggaccttg gagagctcag  13140

gatggctcag acgaggacac tcgcttgccg ggcctgggcc tcctgggaag gagggagctg  13200

ctcagaatgc cgcatgacaa ctgaaggcaa cctggaaggt tcaggggccg ctcttccccc  13260

atgtgcctgt cacgctctgg tgcagtcaaa ggaacgcctt cccctcagtt gtttctaaga  13320

gcagagtctc ccgctgcaat ctgggtggta actgccagcc ttggaggatc gtggccaacg  13380

tggacctgcc tacggagggt gggctctgac ccaagtgggg cctccttgtc caggtctcac  13440

tgctttgcac cgtggtcaga gggactgtca gctgagcttg agctcccctg gagccagcag  13500

ggctgtgatg ggcgagtccc ggagccccac ccagacctga atgcttctga gagcaaaggg  13560

aaggactgac gagagatgta tatttaattt tttaactgct gcaaacattg tacatccaaa  13620

ttaaaggaaa aaaatggaaa ccatca                                       13646


<210>  1877
<211>  3142
<212>  PRT
<213>  Homo sapiens

<400>  1877


Met Ala Thr Leu Glu Lys Leu Met Lys Ala Phe Glu Ser Leu Lys Ser 
1               5                   10                  15      


Phe Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
            20                  25                  30          


Gln Gln Gln Gln Gln Gln Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro 
        35                  40                  45              


Pro Gln Leu Pro Gln Pro Pro Pro Gln Ala Gln Pro Leu Leu Pro Gln 
    50                  55                  60                  


Pro Gln Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Gly Pro Ala Val 
65                  70                  75                  80  


Ala Glu Glu Pro Leu His Arg Pro Lys Lys Glu Leu Ser Ala Thr Lys 
                85                  90                  95      


Lys Asp Arg Val Asn His Cys Leu Thr Ile Cys Glu Asn Ile Val Ala 
            100                 105                 110         


Gln Ser Val Arg Asn Ser Pro Glu Phe Gln Lys Leu Leu Gly Ile Ala 
        115                 120                 125             


Met Glu Leu Phe Leu Leu Cys Ser Asp Asp Ala Glu Ser Asp Val Arg 
    130                 135                 140                 


Met Val Ala Asp Glu Cys Leu Asn Lys Val Ile Lys Ala Leu Met Asp 
145                 150                 155                 160 


Ser Asn Leu Pro Arg Leu Gln Leu Glu Leu Tyr Lys Glu Ile Lys Lys 
                165                 170                 175     


Asn Gly Ala Pro Arg Ser Leu Arg Ala Ala Leu Trp Arg Phe Ala Glu 
            180                 185                 190         


Leu Ala His Leu Val Arg Pro Gln Lys Cys Arg Pro Tyr Leu Val Asn 
        195                 200                 205             


Leu Leu Pro Cys Leu Thr Arg Thr Ser Lys Arg Pro Glu Glu Ser Val 
    210                 215                 220                 


Gln Glu Thr Leu Ala Ala Ala Val Pro Lys Ile Met Ala Ser Phe Gly 
225                 230                 235                 240 


Asn Phe Ala Asn Asp Asn Glu Ile Lys Val Leu Leu Lys Ala Phe Ile 
                245                 250                 255     


Ala Asn Leu Lys Ser Ser Ser Pro Thr Ile Arg Arg Thr Ala Ala Gly 
            260                 265                 270         


Ser Ala Val Ser Ile Cys Gln His Ser Arg Arg Thr Gln Tyr Phe Tyr 
        275                 280                 285             


Ser Trp Leu Leu Asn Val Leu Leu Gly Leu Leu Val Pro Val Glu Asp 
    290                 295                 300                 


Glu His Ser Thr Leu Leu Ile Leu Gly Val Leu Leu Thr Leu Arg Tyr 
305                 310                 315                 320 


Leu Val Pro Leu Leu Gln Gln Gln Val Lys Asp Thr Ser Leu Lys Gly 
                325                 330                 335     


Ser Phe Gly Val Thr Arg Lys Glu Met Glu Val Ser Pro Ser Ala Glu 
            340                 345                 350         


Gln Leu Val Gln Val Tyr Glu Leu Thr Leu His His Thr Gln His Gln 
        355                 360                 365             


Asp His Asn Val Val Thr Gly Ala Leu Glu Leu Leu Gln Gln Leu Phe 
    370                 375                 380                 


Arg Thr Pro Pro Pro Glu Leu Leu Gln Thr Leu Thr Ala Val Gly Gly 
385                 390                 395                 400 


Ile Gly Gln Leu Thr Ala Ala Lys Glu Glu Ser Gly Gly Arg Ser Arg 
                405                 410                 415     


Ser Gly Ser Ile Val Glu Leu Ile Ala Gly Gly Gly Ser Ser Cys Ser 
            420                 425                 430         


Pro Val Leu Ser Arg Lys Gln Lys Gly Lys Val Leu Leu Gly Glu Glu 
        435                 440                 445             


Glu Ala Leu Glu Asp Asp Ser Glu Ser Arg Ser Asp Val Ser Ser Ser 
    450                 455                 460                 


Ala Leu Thr Ala Ser Val Lys Asp Glu Ile Ser Gly Glu Leu Ala Ala 
465                 470                 475                 480 


Ser Ser Gly Val Ser Thr Pro Gly Ser Ala Gly His Asp Ile Ile Thr 
                485                 490                 495     


Glu Gln Pro Arg Ser Gln His Thr Leu Gln Ala Asp Ser Val Asp Leu 
            500                 505                 510         


Ala Ser Cys Asp Leu Thr Ser Ser Ala Thr Asp Gly Asp Glu Glu Asp 
        515                 520                 525             


Ile Leu Ser His Ser Ser Ser Gln Val Ser Ala Val Pro Ser Asp Pro 
    530                 535                 540                 


Ala Met Asp Leu Asn Asp Gly Thr Gln Ala Ser Ser Pro Ile Ser Asp 
545                 550                 555                 560 


Ser Ser Gln Thr Thr Thr Glu Gly Pro Asp Ser Ala Val Thr Pro Ser 
                565                 570                 575     


Asp Ser Ser Glu Ile Val Leu Asp Gly Thr Asp Asn Gln Tyr Leu Gly 
            580                 585                 590         


Leu Gln Ile Gly Gln Pro Gln Asp Glu Asp Glu Glu Ala Thr Gly Ile 
        595                 600                 605             


Leu Pro Asp Glu Ala Ser Glu Ala Phe Arg Asn Ser Ser Met Ala Leu 
    610                 615                 620                 


Gln Gln Ala His Leu Leu Lys Asn Met Ser His Cys Arg Gln Pro Ser 
625                 630                 635                 640 


Asp Ser Ser Val Asp Lys Phe Val Leu Arg Asp Glu Ala Thr Glu Pro 
                645                 650                 655     


Gly Asp Gln Glu Asn Lys Pro Cys Arg Ile Lys Gly Asp Ile Gly Gln 
            660                 665                 670         


Ser Thr Asp Asp Asp Ser Ala Pro Leu Val His Cys Val Arg Leu Leu 
        675                 680                 685             


Ser Ala Ser Phe Leu Leu Thr Gly Gly Lys Asn Val Leu Val Pro Asp 
    690                 695                 700                 


Arg Asp Val Arg Val Ser Val Lys Ala Leu Ala Leu Ser Cys Val Gly 
705                 710                 715                 720 


Ala Ala Val Ala Leu His Pro Glu Ser Phe Phe Ser Lys Leu Tyr Lys 
                725                 730                 735     


Val Pro Leu Asp Thr Thr Glu Tyr Pro Glu Glu Gln Tyr Val Ser Asp 
            740                 745                 750         


Ile Leu Asn Tyr Ile Asp His Gly Asp Pro Gln Val Arg Gly Ala Thr 
        755                 760                 765             


Ala Ile Leu Cys Gly Thr Leu Ile Cys Ser Ile Leu Ser Arg Ser Arg 
    770                 775                 780                 


Phe His Val Gly Asp Trp Met Gly Thr Ile Arg Thr Leu Thr Gly Asn 
785                 790                 795                 800 


Thr Phe Ser Leu Ala Asp Cys Ile Pro Leu Leu Arg Lys Thr Leu Lys 
                805                 810                 815     


Asp Glu Ser Ser Val Thr Cys Lys Leu Ala Cys Thr Ala Val Arg Asn 
            820                 825                 830         


Cys Val Met Ser Leu Cys Ser Ser Ser Tyr Ser Glu Leu Gly Leu Gln 
        835                 840                 845             


Leu Ile Ile Asp Val Leu Thr Leu Arg Asn Ser Ser Tyr Trp Leu Val 
    850                 855                 860                 


Arg Thr Glu Leu Leu Glu Thr Leu Ala Glu Ile Asp Phe Arg Leu Val 
865                 870                 875                 880 


Ser Phe Leu Glu Ala Lys Ala Glu Asn Leu His Arg Gly Ala His His 
                885                 890                 895     


Tyr Thr Gly Leu Leu Lys Leu Gln Glu Arg Val Leu Asn Asn Val Val 
            900                 905                 910         


Ile His Leu Leu Gly Asp Glu Asp Pro Arg Val Arg His Val Ala Ala 
        915                 920                 925             


Ala Ser Leu Ile Arg Leu Val Pro Lys Leu Phe Tyr Lys Cys Asp Gln 
    930                 935                 940                 


Gly Gln Ala Asp Pro Val Val Ala Val Ala Arg Asp Gln Ser Ser Val 
945                 950                 955                 960 


Tyr Leu Lys Leu Leu Met His Glu Thr Gln Pro Pro Ser His Phe Ser 
                965                 970                 975     


Val Ser Thr Ile Thr Arg Ile Tyr Arg Gly Tyr Asn Leu Leu Pro Ser 
            980                 985                 990         


Ile Thr Asp Val Thr Met Glu Asn  Asn Leu Ser Arg Val  Ile Ala Ala 
        995                 1000                 1005             


Val Ser  His Glu Leu Ile Thr  Ser Thr Thr Arg Ala  Leu Thr Phe 
    1010                 1015                 1020             


Gly Cys  Cys Glu Ala Leu Cys  Leu Leu Ser Thr Ala  Phe Pro Val 
    1025                 1030                 1035             


Cys Ile  Trp Ser Leu Gly Trp  His Cys Gly Val Pro  Pro Leu Ser 
    1040                 1045                 1050             


Ala Ser  Asp Glu Ser Arg Lys  Ser Cys Thr Val Gly  Met Ala Thr 
    1055                 1060                 1065             


Met Ile  Leu Thr Leu Leu Ser  Ser Ala Trp Phe Pro  Leu Asp Leu 
    1070                 1075                 1080             


Ser Ala  His Gln Asp Ala Leu  Ile Leu Ala Gly Asn  Leu Leu Ala 
    1085                 1090                 1095             


Ala Ser  Ala Pro Lys Ser Leu  Arg Ser Ser Trp Ala  Ser Glu Glu 
    1100                 1105                 1110             


Glu Ala  Asn Pro Ala Ala Thr  Lys Gln Glu Glu Val  Trp Pro Ala 
    1115                 1120                 1125             


Leu Gly  Asp Arg Ala Leu Val  Pro Met Val Glu Gln  Leu Phe Ser 
    1130                 1135                 1140             


His Leu  Leu Lys Val Ile Asn  Ile Cys Ala His Val  Leu Asp Asp 
    1145                 1150                 1155             


Val Ala  Pro Gly Pro Ala Ile  Lys Ala Ala Leu Pro  Ser Leu Thr 
    1160                 1165                 1170             


Asn Pro  Pro Ser Leu Ser Pro  Ile Arg Arg Lys Gly  Lys Glu Lys 
    1175                 1180                 1185             


Glu Pro  Gly Glu Gln Ala Ser  Val Pro Leu Ser Pro  Lys Lys Gly 
    1190                 1195                 1200             


Ser Glu  Ala Ser Ala Ala Ser  Arg Gln Ser Asp Thr  Ser Gly Pro 
    1205                 1210                 1215             


Val Thr  Thr Ser Lys Ser Ser  Ser Leu Gly Ser Phe  Tyr His Leu 
    1220                 1225                 1230             


Pro Ser  Tyr Leu Lys Leu His  Asp Val Leu Lys Ala  Thr His Ala 
    1235                 1240                 1245             


Asn Tyr  Lys Val Thr Leu Asp  Leu Gln Asn Ser Thr  Glu Lys Phe 
    1250                 1255                 1260             


Gly Gly  Phe Leu Arg Ser Ala  Leu Asp Val Leu Ser  Gln Ile Leu 
    1265                 1270                 1275             


Glu Leu  Ala Thr Leu Gln Asp  Ile Gly Lys Cys Val  Glu Glu Ile 
    1280                 1285                 1290             


Leu Gly  Tyr Leu Lys Ser Cys  Phe Ser Arg Glu Pro  Met Met Ala 
    1295                 1300                 1305             


Thr Val  Cys Val Gln Gln Leu  Leu Lys Thr Leu Phe  Gly Thr Asn 
    1310                 1315                 1320             


Leu Ala  Ser Gln Phe Asp Gly  Leu Ser Ser Asn Pro  Ser Lys Ser 
    1325                 1330                 1335             


Gln Gly  Arg Ala Gln Arg Leu  Gly Ser Ser Ser Val  Arg Pro Gly 
    1340                 1345                 1350             


Leu Tyr  His Tyr Cys Phe Met  Ala Pro Tyr Thr His  Phe Thr Gln 
    1355                 1360                 1365             


Ala Leu  Ala Asp Ala Ser Leu  Arg Asn Met Val Gln  Ala Glu Gln 
    1370                 1375                 1380             


Glu Asn  Asp Thr Ser Gly Trp  Phe Asp Val Leu Gln  Lys Val Ser 
    1385                 1390                 1395             


Thr Gln  Leu Lys Thr Asn Leu  Thr Ser Val Thr Lys  Asn Arg Ala 
    1400                 1405                 1410             


Asp Lys  Asn Ala Ile His Asn  His Ile Arg Leu Phe  Glu Pro Leu 
    1415                 1420                 1425             


Val Ile  Lys Ala Leu Lys Gln  Tyr Thr Thr Thr Thr  Cys Val Gln 
    1430                 1435                 1440             


Leu Gln  Lys Gln Val Leu Asp  Leu Leu Ala Gln Leu  Val Gln Leu 
    1445                 1450                 1455             


Arg Val  Asn Tyr Cys Leu Leu  Asp Ser Asp Gln Val  Phe Ile Gly 
    1460                 1465                 1470             


Phe Val  Leu Lys Gln Phe Glu  Tyr Ile Glu Val Gly  Gln Phe Arg 
    1475                 1480                 1485             


Glu Ser  Glu Ala Ile Ile Pro  Asn Ile Phe Phe Phe  Leu Val Leu 
    1490                 1495                 1500             


Leu Ser  Tyr Glu Arg Tyr His  Ser Lys Gln Ile Ile  Gly Ile Pro 
    1505                 1510                 1515             


Lys Ile  Ile Gln Leu Cys Asp  Gly Ile Met Ala Ser  Gly Arg Lys 
    1520                 1525                 1530             


Ala Val  Thr His Ala Ile Pro  Ala Leu Gln Pro Ile  Val His Asp 
    1535                 1540                 1545             


Leu Phe  Val Leu Arg Gly Thr  Asn Lys Ala Asp Ala  Gly Lys Glu 
    1550                 1555                 1560             


Leu Glu  Thr Gln Lys Glu Val  Val Val Ser Met Leu  Leu Arg Leu 
    1565                 1570                 1575             


Ile Gln  Tyr His Gln Val Leu  Glu Met Phe Ile Leu  Val Leu Gln 
    1580                 1585                 1590             


Gln Cys  His Lys Glu Asn Glu  Asp Lys Trp Lys Arg  Leu Ser Arg 
    1595                 1600                 1605             


Gln Ile  Ala Asp Ile Ile Leu  Pro Met Leu Ala Lys  Gln Gln Met 
    1610                 1615                 1620             


His Ile  Asp Ser His Glu Ala  Leu Gly Val Leu Asn  Thr Leu Phe 
    1625                 1630                 1635             


Glu Ile  Leu Ala Pro Ser Ser  Leu Arg Pro Val Asp  Met Leu Leu 
    1640                 1645                 1650             


Arg Ser  Met Phe Val Thr Pro  Asn Thr Met Ala Ser  Val Ser Thr 
    1655                 1660                 1665             


Val Gln  Leu Trp Ile Ser Gly  Ile Leu Ala Ile Leu  Arg Val Leu 
    1670                 1675                 1680             


Ile Ser  Gln Ser Thr Glu Asp  Ile Val Leu Ser Arg  Ile Gln Glu 
    1685                 1690                 1695             


Leu Ser  Phe Ser Pro Tyr Leu  Ile Ser Cys Thr Val  Ile Asn Arg 
    1700                 1705                 1710             


Leu Arg  Asp Gly Asp Ser Thr  Ser Thr Leu Glu Glu  His Ser Glu 
    1715                 1720                 1725             


Gly Lys  Gln Ile Lys Asn Leu  Pro Glu Glu Thr Phe  Ser Arg Phe 
    1730                 1735                 1740             


Leu Leu  Gln Leu Val Gly Ile  Leu Leu Glu Asp Ile  Val Thr Lys 
    1745                 1750                 1755             


Gln Leu  Lys Val Glu Met Ser  Glu Gln Gln His Thr  Phe Tyr Cys 
    1760                 1765                 1770             


Gln Glu  Leu Gly Thr Leu Leu  Met Cys Leu Ile His  Ile Phe Lys 
    1775                 1780                 1785             


Ser Gly  Met Phe Arg Arg Ile  Thr Ala Ala Ala Thr  Arg Leu Phe 
    1790                 1795                 1800             


Arg Ser  Asp Gly Cys Gly Gly  Ser Phe Tyr Thr Leu  Asp Ser Leu 
    1805                 1810                 1815             


Asn Leu  Arg Ala Arg Ser Met  Ile Thr Thr His Pro  Ala Leu Val 
    1820                 1825                 1830             


Leu Leu  Trp Cys Gln Ile Leu  Leu Leu Val Asn His  Thr Asp Tyr 
    1835                 1840                 1845             


Arg Trp  Trp Ala Glu Val Gln  Gln Thr Pro Lys Arg  His Ser Leu 
    1850                 1855                 1860             


Ser Ser  Thr Lys Leu Leu Ser  Pro Gln Met Ser Gly  Glu Glu Glu 
    1865                 1870                 1875             


Asp Ser  Asp Leu Ala Ala Lys  Leu Gly Met Cys Asn  Arg Glu Ile 
    1880                 1885                 1890             


Val Arg  Arg Gly Ala Leu Ile  Leu Phe Cys Asp Tyr  Val Cys Gln 
    1895                 1900                 1905             


Asn Leu  His Asp Ser Glu His  Leu Thr Trp Leu Ile  Val Asn His 
    1910                 1915                 1920             


Ile Gln  Asp Leu Ile Ser Leu  Ser His Glu Pro Pro  Val Gln Asp 
    1925                 1930                 1935             


Phe Ile  Ser Ala Val His Arg  Asn Ser Ala Ala Ser  Gly Leu Phe 
    1940                 1945                 1950             


Ile Gln  Ala Ile Gln Ser Arg  Cys Glu Asn Leu Ser  Thr Pro Thr 
    1955                 1960                 1965             


Met Leu  Lys Lys Thr Leu Gln  Cys Leu Glu Gly Ile  His Leu Ser 
    1970                 1975                 1980             


Gln Ser  Gly Ala Val Leu Thr  Leu Tyr Val Asp Arg  Leu Leu Cys 
    1985                 1990                 1995             


Thr Pro  Phe Arg Val Leu Ala  Arg Met Val Asp Ile  Leu Ala Cys 
    2000                 2005                 2010             


Arg Arg  Val Glu Met Leu Leu  Ala Ala Asn Leu Gln  Ser Ser Met 
    2015                 2020                 2025             


Ala Gln  Leu Pro Met Glu Glu  Leu Asn Arg Ile Gln  Glu Tyr Leu 
    2030                 2035                 2040             


Gln Ser  Ser Gly Leu Ala Gln  Arg His Gln Arg Leu  Tyr Ser Leu 
    2045                 2050                 2055             


Leu Asp  Arg Phe Arg Leu Ser  Thr Met Gln Asp Ser  Leu Ser Pro 
    2060                 2065                 2070             


Ser Pro  Pro Val Ser Ser His  Pro Leu Asp Gly Asp  Gly His Val 
    2075                 2080                 2085             


Ser Leu  Glu Thr Val Ser Pro  Asp Lys Asp Trp Tyr  Val His Leu 
    2090                 2095                 2100             


Val Lys  Ser Gln Cys Trp Thr  Arg Ser Asp Ser Ala  Leu Leu Glu 
    2105                 2110                 2115             


Gly Ala  Glu Leu Val Asn Arg  Ile Pro Ala Glu Asp  Met Asn Ala 
    2120                 2125                 2130             


Phe Met  Met Asn Ser Glu Phe  Asn Leu Ser Leu Leu  Ala Pro Cys 
    2135                 2140                 2145             


Leu Ser  Leu Gly Met Ser Glu  Ile Ser Gly Gly Gln  Lys Ser Ala 
    2150                 2155                 2160             


Leu Phe  Glu Ala Ala Arg Glu  Val Thr Leu Ala Arg  Val Ser Gly 
    2165                 2170                 2175             


Thr Val  Gln Gln Leu Pro Ala  Val His His Val Phe  Gln Pro Glu 
    2180                 2185                 2190             


Leu Pro  Ala Glu Pro Ala Ala  Tyr Trp Ser Lys Leu  Asn Asp Leu 
    2195                 2200                 2205             


Phe Gly  Asp Ala Ala Leu Tyr  Gln Ser Leu Pro Thr  Leu Ala Arg 
    2210                 2215                 2220             


Ala Leu  Ala Gln Tyr Leu Val  Val Val Ser Lys Leu  Pro Ser His 
    2225                 2230                 2235             


Leu His  Leu Pro Pro Glu Lys  Glu Lys Asp Ile Val  Lys Phe Val 
    2240                 2245                 2250             


Val Ala  Thr Leu Glu Ala Leu  Ser Trp His Leu Ile  His Glu Gln 
    2255                 2260                 2265             


Ile Pro  Leu Ser Leu Asp Leu  Gln Ala Gly Leu Asp  Cys Cys Cys 
    2270                 2275                 2280             


Leu Ala  Leu Gln Leu Pro Gly  Leu Trp Ser Val Val  Ser Ser Thr 
    2285                 2290                 2295             


Glu Phe  Val Thr His Ala Cys  Ser Leu Ile Tyr Cys  Val His Phe 
    2300                 2305                 2310             


Ile Leu  Glu Ala Val Ala Val  Gln Pro Gly Glu Gln  Leu Leu Ser 
    2315                 2320                 2325             


Pro Glu  Arg Arg Thr Asn Thr  Pro Lys Ala Ile Ser  Glu Glu Glu 
    2330                 2335                 2340             


Glu Glu  Val Asp Pro Asn Thr  Gln Asn Pro Lys Tyr  Ile Thr Ala 
    2345                 2350                 2355             


Ala Cys  Glu Met Val Ala Glu  Met Val Glu Ser Leu  Gln Ser Val 
    2360                 2365                 2370             


Leu Ala  Leu Gly His Lys Arg  Asn Ser Gly Val Pro  Ala Phe Leu 
    2375                 2380                 2385             


Thr Pro  Leu Leu Arg Asn Ile  Ile Ile Ser Leu Ala  Arg Leu Pro 
    2390                 2395                 2400             


Leu Val  Asn Ser Tyr Thr Arg  Val Pro Pro Leu Val  Trp Lys Leu 
    2405                 2410                 2415             


Gly Trp  Ser Pro Lys Pro Gly  Gly Asp Phe Gly Thr  Ala Phe Pro 
    2420                 2425                 2430             


Glu Ile  Pro Val Glu Phe Leu  Gln Glu Lys Glu Val  Phe Lys Glu 
    2435                 2440                 2445             


Phe Ile  Tyr Arg Ile Asn Thr  Leu Gly Trp Thr Ser  Arg Thr Gln 
    2450                 2455                 2460             


Phe Glu  Glu Thr Trp Ala Thr  Leu Leu Gly Val Leu  Val Thr Gln 
    2465                 2470                 2475             


Pro Leu  Val Met Glu Gln Glu  Glu Ser Pro Pro Glu  Glu Asp Thr 
    2480                 2485                 2490             


Glu Arg  Thr Gln Ile Asn Val  Leu Ala Val Gln Ala  Ile Thr Ser 
    2495                 2500                 2505             


Leu Val  Leu Ser Ala Met Thr  Val Pro Val Ala Gly  Asn Pro Ala 
    2510                 2515                 2520             


Val Ser  Cys Leu Glu Gln Gln  Pro Arg Asn Lys Pro  Leu Lys Ala 
    2525                 2530                 2535             


Leu Asp  Thr Arg Phe Gly Arg  Lys Leu Ser Ile Ile  Arg Gly Ile 
    2540                 2545                 2550             


Val Glu  Gln Glu Ile Gln Ala  Met Val Ser Lys Arg  Glu Asn Ile 
    2555                 2560                 2565             


Ala Thr  His His Leu Tyr Gln  Ala Trp Asp Pro Val  Pro Ser Leu 
    2570                 2575                 2580             


Ser Pro  Ala Thr Thr Gly Ala  Leu Ile Ser His Glu  Lys Leu Leu 
    2585                 2590                 2595             


Leu Gln  Ile Asn Pro Glu Arg  Glu Leu Gly Ser Met  Ser Tyr Lys 
    2600                 2605                 2610             


Leu Gly  Gln Val Ser Ile His  Ser Val Trp Leu Gly  Asn Ser Ile 
    2615                 2620                 2625             


Thr Pro  Leu Arg Glu Glu Glu  Trp Asp Glu Glu Glu  Glu Glu Glu 
    2630                 2635                 2640             


Ala Asp  Ala Pro Ala Pro Ser  Ser Pro Pro Thr Ser  Pro Val Asn 
    2645                 2650                 2655             


Ser Arg  Lys His Arg Ala Gly  Val Asp Ile His Ser  Cys Ser Gln 
    2660                 2665                 2670             


Phe Leu  Leu Glu Leu Tyr Ser  Arg Trp Ile Leu Pro  Ser Ser Ser 
    2675                 2680                 2685             


Ala Arg  Arg Thr Pro Ala Ile  Leu Ile Ser Glu Val  Val Arg Ser 
    2690                 2695                 2700             


Leu Leu  Val Val Ser Asp Leu  Phe Thr Glu Arg Asn  Gln Phe Glu 
    2705                 2710                 2715             


Leu Met  Tyr Val Thr Leu Thr  Glu Leu Arg Arg Val  His Pro Ser 
    2720                 2725                 2730             


Glu Asp  Glu Ile Leu Ala Gln  Tyr Leu Val Pro Ala  Thr Cys Lys 
    2735                 2740                 2745             


Ala Ala  Ala Val Leu Gly Met  Asp Lys Ala Val Ala  Glu Pro Val 
    2750                 2755                 2760             


Ser Arg  Leu Leu Glu Ser Thr  Leu Arg Ser Ser His  Leu Pro Ser 
    2765                 2770                 2775             


Arg Val  Gly Ala Leu His Gly  Val Leu Tyr Val Leu  Glu Cys Asp 
    2780                 2785                 2790             


Leu Leu  Asp Asp Thr Ala Lys  Gln Leu Ile Pro Val  Ile Ser Asp 
    2795                 2800                 2805             


Tyr Leu  Leu Ser Asn Leu Lys  Gly Ile Ala His Cys  Val Asn Ile 
    2810                 2815                 2820             


His Ser  Gln Gln His Val Leu  Val Met Cys Ala Thr  Ala Phe Tyr 
    2825                 2830                 2835             


Leu Ile  Glu Asn Tyr Pro Leu  Asp Val Gly Pro Glu  Phe Ser Ala 
    2840                 2845                 2850             


Ser Ile  Ile Gln Met Cys Gly  Val Met Leu Ser Gly  Ser Glu Glu 
    2855                 2860                 2865             


Ser Thr  Pro Ser Ile Ile Tyr  His Cys Ala Leu Arg  Gly Leu Glu 
    2870                 2875                 2880             


Arg Leu  Leu Leu Ser Glu Gln  Leu Ser Arg Leu Asp  Ala Glu Ser 
    2885                 2890                 2895             


Leu Val  Lys Leu Ser Val Asp  Arg Val Asn Val His  Ser Pro His 
    2900                 2905                 2910             


Arg Ala  Met Ala Ala Leu Gly  Leu Met Leu Thr Cys  Met Tyr Thr 
    2915                 2920                 2925             


Gly Lys  Glu Lys Val Ser Pro  Gly Arg Thr Ser Asp  Pro Asn Pro 
    2930                 2935                 2940             


Ala Ala  Pro Asp Ser Glu Ser  Val Ile Val Ala Met  Glu Arg Val 
    2945                 2950                 2955             


Ser Val  Leu Phe Asp Arg Ile  Arg Lys Gly Phe Pro  Cys Glu Ala 
    2960                 2965                 2970             


Arg Val  Val Ala Arg Ile Leu  Pro Gln Phe Leu Asp  Asp Phe Phe 
    2975                 2980                 2985             


Pro Pro  Gln Asp Ile Met Asn  Lys Val Ile Gly Glu  Phe Leu Ser 
    2990                 2995                 3000             


Asn Gln  Gln Pro Tyr Pro Gln  Phe Met Ala Thr Val  Val Tyr Lys 
    3005                 3010                 3015             


Val Phe  Gln Thr Leu His Ser  Thr Gly Gln Ser Ser  Met Val Arg 
    3020                 3025                 3030             


Asp Trp  Val Met Leu Ser Leu  Ser Asn Phe Thr Gln  Arg Ala Pro 
    3035                 3040                 3045             


Val Ala  Met Ala Thr Trp Ser  Leu Ser Cys Phe Phe  Val Ser Ala 
    3050                 3055                 3060             


Ser Thr  Ser Pro Trp Val Ala  Ala Ile Leu Pro His  Val Ile Ser 
    3065                 3070                 3075             


Arg Met  Gly Lys Leu Glu Gln  Val Asp Val Asn Leu  Phe Cys Leu 
    3080                 3085                 3090             


Val Ala  Thr Asp Phe Tyr Arg  His Gln Ile Glu Glu  Glu Leu Asp 
    3095                 3100                 3105             


Arg Arg  Ala Phe Gln Ser Val  Leu Glu Val Val Ala  Ala Pro Gly 
    3110                 3115                 3120             


Ser Pro  Tyr His Arg Leu Leu  Thr Cys Leu Arg Asn  Val His Lys 
    3125                 3130                 3135             


Val Thr  Thr Cys 
    3140         

<210>  1878
<211>  11251
<212>  DNA
<213>  Homo sapiens

<400>  1878
gaaccctcct gcttgttctc ttgttatcta atacccctat tgacagcgca gcttagatca     60

ttaatggaga gcttgacctc atctgatacc ttcactgaag gaaacaactt agtgtctttt    120

gtgttgaaca ctgaggtaaa aaattggaat agttgattat atgaactctg ctaaaattga    180

gtgcatttta cattttttaa ggccttgttg ggccctggtt aaataattat ttttaaaaat    240

ccttaaggag cctattataa acagatctgt ggtcttaatg aaatgtgatt aatactgtgc    300

attattttaa gaacttttga cttttcaaaa aacttttaca acatttccca tttgatagcg    360

gcataggttt aagcacttct catctctaag ttagtggaca aaaaaccctc atggatagtc    420

taataatgtt tgctacaagt ccatgttgag ttttatactc cattttattt tcagttttaa    480

aaactgtggt taaatatgtg taacataaaa tttatgttct taaccatttt ttgcgtatac    540

agttcgctgg tattaaatac atttaaataa tgtcatggaa tcattgctac cacccatctc    600

tgtaaccttt tgatcatgta acactgaagc tctgttccca ttgaactcta ttcctccttt    660

cccgccaagt ccctggcaac cacgattctt ctttctgtct tctgaatttg actactttgg    720

gttctcatat actttaggag tcacacagta tttgttttac ttagcataat gtccccaaag    780

ctcatgcatg ttgtagccta tgttagaact tcctaatgtt tcaggccaaa tactattcca    840

ttgtatggat aggccacatt ttgcttttcc attcctctgt ccatggacac ttgtattgct    900

tcatgtttta gccattgtga atcatgctgt tatgaacgtg ggtgtacaga tagctcctgg    960

agactctgct ttccattttt ttggctaaat acccagaaat ggagttgctt ttacattcca   1020

attttaattt aaaacattca tatcattgag tgttttactt aatagtatag tagttaacaa   1080

acttaataaa atagtatttt ggtaataatt tgctggtagt ccattgttca gtttttttag   1140

gtaaattaca caggacattt caagtggaca tgaaacatct tgtgatgtgg aatcatgccc   1200

caagctgatg gctaaacata tgaaatacca taccctaaat ttagtagatt tagtctttgc   1260

aatttaggag ataacctgtt atattgttag gtttttgtcg aaaagctttg tcctcatatt   1320

tccaacttgc tgtaaaattt gtttgtgaag acaaatattt ttgtatgggt tttttctttt   1380

tcatattaaa aagaaatgtc cacattggaa tttttttgga gtttttagag ctaatagagc   1440

ttttcataat gtagtgggaa tgagtgatca gtaagctctt agcagtttcc atgcgtgcat   1500

ttctgtgcct tgaaataaat gacagatgag tacatttgtg ttctgtgtgt aaaatgtgct   1560

ctttcctcat tgcacttcca tgttggaggg cttgtctctt ggtgatcaca cttcaaaatt   1620

ctcacagccc cccttgaacc gtttaggtgt tagacggtac cgacaaccag tatttgggcc   1680

tgcagattgg acagccccag gatgaagatg aggaagccac aggtattctt cctgatgaag   1740

cctcggaggc cttcaggaac tcttccatgg gtatgtggac tacaggtgat gcgctacaaa   1800

gtggtttgta ttcagacctg gacatcttaa ttatatcttt gcttccaaga agaagtcctt   1860

tgatactgtt ttctgagttc tgaatagctg atgaaaatga ccaattgagg aataatcata   1920

ctttttcttg atctaaatct tatacttttg agttatctta gcataaatgt ataattgtat   1980

tttaagtgga aatttgtcac ttaatcttga tttctctgtt tttaaagccc ttcaacaggc   2040

acatttattg aaaaacatga gtcactgcag gcagccttct gacagcagtg ttgataaatt   2100

tgtgttgaga gatgaagcta ctgaaccggg tgatcaagaa aacaagcctt gccgcatcaa   2160

aggtgacatt ggacagtcca ctgatgatga ctctgcacct cttgtccatt gtgtccgcct   2220

tttatctgct tcgtttttgc taacaggggg aaaaaatgtg ctggttccgg acagggatgt   2280

gagggtcagc gtgaaggccc tggccctcag ctgtgtggga gcagctgtgg ccctccaccc   2340

ggaatctttc ttcagcaaac tctataaagt tcctcttgac accacggaat accctgagga   2400

acagtatgtc tcagacatct tgaactacat cgatcatgga gacccacagg ttcgaggagc   2460

cactgccatt ctctgtggga ccctcatctg ctccatcctc agcaggtccc gcttccacgt   2520

gggagattgg atgggcacca ttagaaccct cacaggaaat acattttctt tggcggattg   2580

cattcctttg ctgcggaaaa cactgaagga tgagtcttct gttacttgca agttagcttg   2640

tacagctgtg aggaactgtg tcatgagtct ctgcagcagc agctacagtg agttaggact   2700

gcagctgatc atcgatgtgc tgactctgag gaacagttcc tattggctgg tgaggacaga   2760

gcttctggaa acccttgcag agattgactt caggctggtg agctttttgg aggcaaaagc   2820

agaaaactta cacagagggg ctcatcatta tacagggctt ttaaaactgc aagaacgagt   2880

gctcaataat gttgtcatcc atttgcttgg agatgaagac cccagggtgc gacatgttgc   2940

cgcagcatca ctaattaggc ttgtcccaaa gctgttttat aaatgtgacc aaggacaagc   3000

tgatccagta gtggccgtgg caagagatca aagcagtgtt tacctgaaac ttctcatgca   3060

tgagacgcag cctccatctc atttctccgt cagcacaata accagaatat atagaggcta   3120

taacctacta ccaagcataa cagacgtcac tatggaaaat aacctttcaa gagttattgc   3180

agcagtttct catgaactaa tcacatcaac caccagagca ctcacatttg gatgctgtga   3240

agctttgtgt cttctttcca ctgccttccc agtttgcatt tggagtttag gttggcactg   3300

tggagtgcct ccactgagtg cctcagatga gtctaggaag agctgtaccg ttgggatggc   3360

cacaatgatt ctgaccctgc tctcgtcagc ttggttccca ttggatctct cagcccatca   3420

agatgctttg attttggccg gaaacttgct tgcagccagt gctcccaaat ctctgagaag   3480

ttcatgggcc tctgaagaag aagccaaccc agcagccacc aagcaagagg aggtctggcc   3540

agccctgggg gaccgggccc tggtgcccat ggtggagcag ctcttctctc acctgctgaa   3600

ggtgattaac atttgtgccc acgtcctgga tgacgtggct cctggacccg caataaaggc   3660

agccttgcct tctctaacaa accccccttc tctaagtccc atccgacgaa aggggaagga   3720

gaaagaacca ggagaacaag catctgtacc gttgagtccc aagaaaggca gtgaggccag   3780

tgcagcttct agacaatctg atacctcagg tcctgttaca acaagtaaat cctcatcact   3840

ggggagtttc tatcatcttc cttcatacct caaactgcat gatgtcctga aagctacaca   3900

cgctaactac aaggtcacgc tggatcttca gaacagcacg gaaaagtttg gagggtttct   3960

ccgctcagcc ttggatgttc tttctcagat actagagctg gccacactgc aggacattgg   4020

gaagtgtgtt gaagagatcc taggatacct gaaatcctgc tttagtcgag aaccaatgat   4080

ggcaactgtt tgtgttcaac aattgttgaa gactctcttt ggcacaaact tggcctccca   4140

gtttgatggc ttatcttcca accccagcaa gtcacaaggc cgagcacagc gccttggctc   4200

ctccagtgtg aggccaggct tgtaccacta ctgcttcatg gccccgtaca cccacttcac   4260

ccaggccctc gctgacgcca gcctgaggaa catggtgcag gcggagcagg agaacgacac   4320

ctcgggatgg tttgatgtcc tccagaaagt gtctacccag ttgaagacaa acctcacgag   4380

tgtcacaaag aaccgtgcag ataagaatgc tattcataat cacattcgtt tgtttgaacc   4440

tcttgttata aaagctttaa aacagtacac gactacaaca tgtgtgcagt tacagaagca   4500

ggttttagat ttgctggcgc agctggttca gttacgggtt aattactgtc ttctggattc   4560

agatcaggtg tttattggct ttgtattgaa acagtttgaa tacattgaag tgggccagtt   4620

cagggaatca gaggcaatca ttccaaacat ctttttcttc ttggtattac tatcttatga   4680

acgctatcat tcaaaacaga tcattggaat tcctaaaatc attcagctct gtgatggcat   4740

catggccagt ggaaggaagg ctgtgacaca tgccataccg gctctgcagc ccatagtcca   4800

cgacctcttt gtattaagag gaacaaataa agctgatgca ggaaaagagc ttgaaaccca   4860

aaaagaggtg gtggtgtcaa tgttactgag actcatccag taccatcagg tgttggagat   4920

gttcattctt gtcctgcagc agtgccacaa ggagaatgaa gacaagtgga agcgactgtc   4980

tcgacagata gctgacatca tcctcccaat gttagccaaa cagcagatgc acattgactc   5040

tcatgaagcc cttggagtgt taaatacatt atttgagatt ttggcccctt cctccctccg   5100

tccggtagac atgcttttac ggagtatgtt cgtcactcca aacacaatgg cgtccgtgag   5160

cactgttcaa ctgtggatat cgggaattct ggccattttg agggttctga tttcccagtc   5220

aactgaagat attgttcttt ctcgtattca ggagctctcc ttctctccgt atttaatctc   5280

ctgtacagta attaataggt taagagatgg ggacagtact tcaacgctag aagaacacag   5340

tgaagggaaa caaataaaga atttgccaga agaaacattt tcaaggtatg ctttctatct   5400

gagcctataa ctaacccatg ccttttggga agtcacgtga tgtttcacag tcagtaagtc   5460

tggaataata cctggtcttg cttcacttct gagttgggta aagaagtctg tatcagtgta   5520

attttctaat ccgtcctgca ttatctatgg ctcttggttc atacctgtct tgaagttctg   5580

tcatgttctg tctcttgtcc tcagtagaga tgctacagca gtggctcgcc tcaggcaggg   5640

cagggcagtg gggtggctgt cctgggggca ggcagtaggg gcacgctgac gtcagggaag   5700

ttgaaaccca agagaagcca gtaaaagtga gtctcagatt gtcaccatgt gctggcagtt   5760

ttacacgctg tcagtaataa aagtcttctc cctgcagggc agcctgcctc caataaatac   5820

gtgtagtatc aaatcctgtc ttccctcata aattgtttgg aagctcccca aggacagtga   5880

tgaggcactc gtaagtgctt gctgcctaga tgggtccctc tccacctttg ctagattctg   5940

agcattcact gagttagagc tgcttctgca aatgtgctgc ttctgctaag tggctgtgac   6000

ttcatgcagc cttcacttgg tttgtcatca gtggagatgc cctgtgttgt cgaaggagat   6060

aagcccagta agcctgctgg gcaccttttg gtttgcaggt tcagcaggca gcccatggct   6120

ttccctgtgt cgcattgaag cagctggcta aaattgatga tacattaaat tcctgtgaca   6180

gatgatcagc ttgtatttgt gtaatggtgt acagttcaca aagcttaaaa aaatgctacc   6240

tgccatttca tcctcagtga ggaaggtgat acacagagag accaagtgac tgtgtccacg   6300

gcgacggcgc tctgcatttc actttagcgg ttaatgtact ctacctatat ttttacttta   6360

tatttaccat atatcttttc atgtatactt ggcgtaagtg ctttatagta gtcacctaat   6420

tcactgtcat cttttttgtt tcttggaagg tttctattac aactggttgg tattctttta   6480

gaagacattg ttacaaaaca gctgaaggtg gaaatgagtg agcagcaaca tactttctat   6540

tgccaggaac taggcacact gctaatgtgt ctgatccaca tcttcaagtc tggaatgttc   6600

cggagaatca cagcagctgc cactaggctg ttccgcagtg atggctgtgg cggcagtttc   6660

tacaccctgg acagcttgaa cttgcgggct cgttccatga tcaccaccca cccggccctg   6720

gtgctgctct ggtgtcagat actgctgctt gtcaaccaca ccgactaccg ctggtgggca   6780

gaagtgcagc agaccccgaa aagacacagt ctgtccagca caaagttact tagtccccag   6840

atgtctggag aagaggagga ttctgacttg gcagccaaac ttggaatgtg caatagagaa   6900

atagtacgaa gaggggctct cattctcttc tgtgattatg tctgtcagaa cctccatgac   6960

tccgagcact taacgtggct cattgtaaat cacattcaag atctgatcag cctttcccac   7020

gagcctccag tacaggactt catcagtgcc gttcatcgga actctgctgc cagcggcctg   7080

ttcatccagg caattcagtc tcgttgtgaa aacctttcaa ctccaaccat gctgaagaaa   7140

actcttcagt gcttggaggg gatccatctc agccagtcgg gagctgtgct cacgctgtat   7200

gtggacaggc ttctgtgcac ccctttccgt gtgctggctc gcatggtcga catccttgct   7260

tgtcgccggg tagaaatgct tctggctgca aatttacaga gcagcatggc ccagttgcca   7320

atggaagaac tcaacagaat ccaggaatac cttcagagca gcgggctcgc tcagagacac   7380

caaaggctct attccctgct ggacaggttt cgtctctcca ccatgcaaga ctcacttagt   7440

ccctctcctc cagtctcttc ccacccgctg gacggggatg ggcacgtgtc actggaaaca   7500

gtgagtccgg acaaagactg gtacgttcat cttgtcaaat cccagtgttg gaccaggtca   7560

gattctgcac tgctggaagg tgcagagctg gtgaatcgga ttcctgctga agatatgaat   7620

gccttcatga tgaactcgga gttcaaccta agcctgctag ctccatgctt aagcctaggg   7680

atgagtgaaa tttctggtgg ccagaagagt gccctttttg aagcagcccg tgaggtgact   7740

ctggcccgtg tgagcggcac cgtgcagcag ctccctgctg tccatcatgt cttccagccc   7800

gagctgcctg cagagccggc ggcctactgg agcaagttga atgatctgtt tggggatgct   7860

gcactgtatc agtccctgcc cactctggcc cgggccctgg cacagtacct ggtggtggtc   7920

tccaaactgc ccagtcattt gcaccttcct cctgagaaag agaaggacat tgtgaaattc   7980

gtggtggcaa cccttgaggc cctgtcctgg catttgatcc atgagcagat cccgctgagt   8040

ctggatctcc aggcagggct ggactgctgc tgcctggccc tgcagctgcc tggcctctgg   8100

agcgtggtct cctccacaga gtttgtgacc cacgcctgct ccctcatcta ctgtgtgcac   8160

ttcatcctgg aggccgttgc agtgcagcct ggagagcagc ttcttagtcc agaaagaagg   8220

acaaataccc caaaagccat cagcgaggag gaggaggaag tagatccaaa cacacagaat   8280

cctaagtata tcactgcagc ctgtgagatg gtggcagaaa tggtggagtc tctgcagtcg   8340

gtgttggcct tgggtcataa aaggaatagc ggcgtgccgg cgtttctcac gccattgcta   8400

aggaacatca tcatcagcct ggcccgcctg ccccttgtca acagctacac acgtgtgccc   8460

ccactggtgt ggaagcttgg atggtcaccc aaaccgggag gggattttgg cacagcattc   8520

cctgagatcc ccgtggagtt cctccaggaa aaggaagtct ttaaggagtt catctaccgc   8580

atcaacacac taggctggac cagtcgtact cagtttgaag aaacttgggc caccctcctt   8640

ggtgtcctgg tgacgcagcc cctcgtgatg gagcaggagg agagcccacc agaagaagac   8700

acagagagga cccagatcaa cgtcctggcc gtgcaggcca tcacctcact ggtgctcagt   8760

gcaatgactg tgcctgtggc cggcaaccca gctgtaagct gcttggagca gcagccccgg   8820

aacaagcctc tgaaagctct cgacaccagg tttgggagga agctgagcat tatcagaggg   8880

attgtggagc aagagattca agcaatggtt tcaaagagag agaatattgc cacccatcat   8940

ttatatcagg catgggatcc tgtcccttct ctgtctccgg ctactacagg tgccctcatc   9000

agccacgaga agctgctgct acagatcaac cccgagcggg agctggggag catgagctac   9060

aaactcggcc aggtgtccat acactccgtg tggctgggga acagcatcac acccctgagg   9120

gaggaggaat gggacgagga agaggaggag gaggccgacg cccctgcacc ttcgtcacca   9180

cccacgtctc cagtcaactc caggaaacac cgggctggag ttgacatcca ctcctgttcg   9240

cagtttttgc ttgagttgta cagccgctgg atcctgccgt ccagctcagc caggaggacc   9300

ccggccatcc tgatcagtga ggtggtcaga tcccttctag tggtctcaga cttgttcacc   9360

gagcgcaacc agtttgagct gatgtatgtg acgctgacag aactgcgaag ggtgcaccct   9420

tcagaagacg agatcctcgc tcagtacctg gtgcctgcca cctgcaaggc agctgccgtc   9480

cttgggatgg acaaggccgt ggcggagcct gtcagccgcc tgctggagag cacgctcagg   9540

agcagccacc tgcccagcag ggttggagcc ctgcacggcg tcctctatgt gctggagtgc   9600

gacctgctgg acgacactgc caagcagctc atcccggtca tcagcgacta tctcctctcc   9660

aacctgaaag ggatcgccca ctgcgtgaac attcacagcc agcagcacgt actggtcatg   9720

tgtgccactg cgttttacct cattgagaac tatcctctgg acgtagggcc ggaattttca   9780

gcatcaataa tacagatgtg tggggtgatg ctgtctggaa gtgaggagtc caccccctcc   9840

atcatttacc actgtgccct cagaggcctg gagcgcctcc tgctctctga gcagctctcc   9900

cgcctggatg cagaatcgct ggtcaagctg agtgtggaca gagtgaacgt gcacagcccg   9960

caccgggcca tggcggctct gggcctgatg ctcacctgca tgtacacagg aaaggagaaa  10020

gtcagtccgg gtagaacttc agaccctaat cctgcagccc ccgacagcga gtcagtgatt  10080

gttgctatgg agcgggtatc tgttcttttt gataggatca ggaaaggctt tccttgtgaa  10140

gccagagtgg tggccaggat cctgccccag tttctagacg acttcttccc accccaggac  10200

atcatgaaca aagtcatcgg agagtttctg tccaaccagc agccataccc ccagttcatg  10260

gccaccgtgg tgtataaggt gtttcagact ctgcacagca ccgggcagtc gtccatggtc  10320

cgggactggg tcatgctgtc cctctccaac ttcacgcaga gggccccggt cgccatggcc  10380

acgtggagcc tctcctgctt ctttgtcagc gcgtccacca gcccgtgggt cgcggcgatc  10440

ctcccacatg tcatcagcag gatgggcaag ctggagcagg tggacgtgaa ccttttctgc  10500

ctggtcgcca cagacttcta cagacaccag atagaggagg agctcgaccg cagggccttc  10560

cagtctgtgc ttgaggtggt tgcagcccca ggaagcccat atcaccggct gctgacttgt  10620

ttacgaaatg tccacaaggt caccacctgc tgagcgccat ggtgggagag actgtgaggc  10680

ggcagctggg gccggagcct ttggaagtct gcgcccttgt gccctgcctc caccgagcca  10740

gcttggtccc tatgggcttc cgcacatgcc gcgggcggcc aggcaacgtg cgtgtctctg  10800

ccatgtggca gaagtgctct ttgtggcagt ggccaggcag ggagtgtctg cagtcctggt  10860

ggggctgagc ctgaggcctt ccagaaagca ggagcagctg tgctgcaccc catgtgggtg  10920

accaggtcct ttctcctgat agtcacctgc tggttgttgc caggttgcag ctgctcttgc  10980

atctgggcca gaagtcctcc ctcctgcagg ctggctgttg gcccctctgc tgtcctgcag  11040

tagaaggtgc cgtgagcagg ctttgggaac actggcctgg gtctccctgg tggggtgtgc  11100

atgccacgcc ccgtgtctgg atgcacagat gccatggcct gtgctgggcc agtggctggg  11160

ggtgctagac acccggcacc attctccctt ctctcttttc ttctcaggat ttaaaattta  11220

attatatcag taaagagatt aattttaacg t                                 11251


<210>  1879
<211>  1379
<212>  PRT
<213>  Homo sapiens

<400>  1879


Met Ser Glu Gln Gln His Thr Phe Tyr Cys Gln Glu Leu Gly Thr Leu 
1               5                   10                  15      


Leu Met Cys Leu Ile His Ile Phe Lys Ser Gly Met Phe Arg Arg Ile 
            20                  25                  30          


Thr Ala Ala Ala Thr Arg Leu Phe Arg Ser Asp Gly Cys Gly Gly Ser 
        35                  40                  45              


Phe Tyr Thr Leu Asp Ser Leu Asn Leu Arg Ala Arg Ser Met Ile Thr 
    50                  55                  60                  


Thr His Pro Ala Leu Val Leu Leu Trp Cys Gln Ile Leu Leu Leu Val 
65                  70                  75                  80  


Asn His Thr Asp Tyr Arg Trp Trp Ala Glu Val Gln Gln Thr Pro Lys 
                85                  90                  95      


Arg His Ser Leu Ser Ser Thr Lys Leu Leu Ser Pro Gln Met Ser Gly 
            100                 105                 110         


Glu Glu Glu Asp Ser Asp Leu Ala Ala Lys Leu Gly Met Cys Asn Arg 
        115                 120                 125             


Glu Ile Val Arg Arg Gly Ala Leu Ile Leu Phe Cys Asp Tyr Val Cys 
    130                 135                 140                 


Gln Asn Leu His Asp Ser Glu His Leu Thr Trp Leu Ile Val Asn His 
145                 150                 155                 160 


Ile Gln Asp Leu Ile Ser Leu Ser His Glu Pro Pro Val Gln Asp Phe 
                165                 170                 175     


Ile Ser Ala Val His Arg Asn Ser Ala Ala Ser Gly Leu Phe Ile Gln 
            180                 185                 190         


Ala Ile Gln Ser Arg Cys Glu Asn Leu Ser Thr Pro Thr Met Leu Lys 
        195                 200                 205             


Lys Thr Leu Gln Cys Leu Glu Gly Ile His Leu Ser Gln Ser Gly Ala 
    210                 215                 220                 


Val Leu Thr Leu Tyr Val Asp Arg Leu Leu Cys Thr Pro Phe Arg Val 
225                 230                 235                 240 


Leu Ala Arg Met Val Asp Ile Leu Ala Cys Arg Arg Val Glu Met Leu 
                245                 250                 255     


Leu Ala Ala Asn Leu Gln Ser Ser Met Ala Gln Leu Pro Met Glu Glu 
            260                 265                 270         


Leu Asn Arg Ile Gln Glu Tyr Leu Gln Ser Ser Gly Leu Ala Gln Arg 
        275                 280                 285             


His Gln Arg Leu Tyr Ser Leu Leu Asp Arg Phe Arg Leu Ser Thr Met 
    290                 295                 300                 


Gln Asp Ser Leu Ser Pro Ser Pro Pro Val Ser Ser His Pro Leu Asp 
305                 310                 315                 320 


Gly Asp Gly His Val Ser Leu Glu Thr Val Ser Pro Asp Lys Asp Trp 
                325                 330                 335     


Tyr Val His Leu Val Lys Ser Gln Cys Trp Thr Arg Ser Asp Ser Ala 
            340                 345                 350         


Leu Leu Glu Gly Ala Glu Leu Val Asn Arg Ile Pro Ala Glu Asp Met 
        355                 360                 365             


Asn Ala Phe Met Met Asn Ser Glu Phe Asn Leu Ser Leu Leu Ala Pro 
    370                 375                 380                 


Cys Leu Ser Leu Gly Met Ser Glu Ile Ser Gly Gly Gln Lys Ser Ala 
385                 390                 395                 400 


Leu Phe Glu Ala Ala Arg Glu Val Thr Leu Ala Arg Val Ser Gly Thr 
                405                 410                 415     


Val Gln Gln Leu Pro Ala Val His His Val Phe Gln Pro Glu Leu Pro 
            420                 425                 430         


Ala Glu Pro Ala Ala Tyr Trp Ser Lys Leu Asn Asp Leu Phe Gly Asp 
        435                 440                 445             


Ala Ala Leu Tyr Gln Ser Leu Pro Thr Leu Ala Arg Ala Leu Ala Gln 
    450                 455                 460                 


Tyr Leu Val Val Val Ser Lys Leu Pro Ser His Leu His Leu Pro Pro 
465                 470                 475                 480 


Glu Lys Glu Lys Asp Ile Val Lys Phe Val Val Ala Thr Leu Glu Ala 
                485                 490                 495     


Leu Ser Trp His Leu Ile His Glu Gln Ile Pro Leu Ser Leu Asp Leu 
            500                 505                 510         


Gln Ala Gly Leu Asp Cys Cys Cys Leu Ala Leu Gln Leu Pro Gly Leu 
        515                 520                 525             


Trp Ser Val Val Ser Ser Thr Glu Phe Val Thr His Ala Cys Ser Leu 
    530                 535                 540                 


Ile Tyr Cys Val His Phe Ile Leu Glu Ala Val Ala Val Gln Pro Gly 
545                 550                 555                 560 


Glu Gln Leu Leu Ser Pro Glu Arg Arg Thr Asn Thr Pro Lys Ala Ile 
                565                 570                 575     


Ser Glu Glu Glu Glu Glu Val Asp Pro Asn Thr Gln Asn Pro Lys Tyr 
            580                 585                 590         


Ile Thr Ala Ala Cys Glu Met Val Ala Glu Met Val Glu Ser Leu Gln 
        595                 600                 605             


Ser Val Leu Ala Leu Gly His Lys Arg Asn Ser Gly Val Pro Ala Phe 
    610                 615                 620                 


Leu Thr Pro Leu Leu Arg Asn Ile Ile Ile Ser Leu Ala Arg Leu Pro 
625                 630                 635                 640 


Leu Val Asn Ser Tyr Thr Arg Val Pro Pro Leu Val Trp Lys Leu Gly 
                645                 650                 655     


Trp Ser Pro Lys Pro Gly Gly Asp Phe Gly Thr Ala Phe Pro Glu Ile 
            660                 665                 670         


Pro Val Glu Phe Leu Gln Glu Lys Glu Val Phe Lys Glu Phe Ile Tyr 
        675                 680                 685             


Arg Ile Asn Thr Leu Gly Trp Thr Ser Arg Thr Gln Phe Glu Glu Thr 
    690                 695                 700                 


Trp Ala Thr Leu Leu Gly Val Leu Val Thr Gln Pro Leu Val Met Glu 
705                 710                 715                 720 


Gln Glu Glu Ser Pro Pro Glu Glu Asp Thr Glu Arg Thr Gln Ile Asn 
                725                 730                 735     


Val Leu Ala Val Gln Ala Ile Thr Ser Leu Val Leu Ser Ala Met Thr 
            740                 745                 750         


Val Pro Val Ala Gly Asn Pro Ala Val Ser Cys Leu Glu Gln Gln Pro 
        755                 760                 765             


Arg Asn Lys Pro Leu Lys Ala Leu Asp Thr Arg Phe Gly Arg Lys Leu 
    770                 775                 780                 


Ser Ile Ile Arg Gly Ile Val Glu Gln Glu Ile Gln Ala Met Val Ser 
785                 790                 795                 800 


Lys Arg Glu Asn Ile Ala Thr His His Leu Tyr Gln Ala Trp Asp Pro 
                805                 810                 815     


Val Pro Ser Leu Ser Pro Ala Thr Thr Gly Ala Leu Ile Ser His Glu 
            820                 825                 830         


Lys Leu Leu Leu Gln Ile Asn Pro Glu Arg Glu Leu Gly Ser Met Ser 
        835                 840                 845             


Tyr Lys Leu Gly Gln Val Ser Ile His Ser Val Trp Leu Gly Asn Ser 
    850                 855                 860                 


Ile Thr Pro Leu Arg Glu Glu Glu Trp Asp Glu Glu Glu Glu Glu Glu 
865                 870                 875                 880 


Ala Asp Ala Pro Ala Pro Ser Ser Pro Pro Thr Ser Pro Val Asn Ser 
                885                 890                 895     


Arg Lys His Arg Ala Gly Val Asp Ile His Ser Cys Ser Gln Phe Leu 
            900                 905                 910         


Leu Glu Leu Tyr Ser Arg Trp Ile Leu Pro Ser Ser Ser Ala Arg Arg 
        915                 920                 925             


Thr Pro Ala Ile Leu Ile Ser Glu Val Val Arg Ser Leu Leu Val Val 
    930                 935                 940                 


Ser Asp Leu Phe Thr Glu Arg Asn Gln Phe Glu Leu Met Tyr Val Thr 
945                 950                 955                 960 


Leu Thr Glu Leu Arg Arg Val His Pro Ser Glu Asp Glu Ile Leu Ala 
                965                 970                 975     


Gln Tyr Leu Val Pro Ala Thr Cys Lys Ala Ala Ala Val Leu Gly Met 
            980                 985                 990         


Asp Lys Ala Val Ala Glu Pro Val  Ser Arg Leu Leu Glu  Ser Thr Leu 
        995                 1000                 1005             


Arg Ser  Ser His Leu Pro Ser  Arg Val Gly Ala Leu  His Gly Val 
    1010                 1015                 1020             


Leu Tyr  Val Leu Glu Cys Asp  Leu Leu Asp Asp Thr  Ala Lys Gln 
    1025                 1030                 1035             


Leu Ile  Pro Val Ile Ser Asp  Tyr Leu Leu Ser Asn  Leu Lys Gly 
    1040                 1045                 1050             


Ile Ala  His Cys Val Asn Ile  His Ser Gln Gln His  Val Leu Val 
    1055                 1060                 1065             


Met Cys  Ala Thr Ala Phe Tyr  Leu Ile Glu Asn Tyr  Pro Leu Asp 
    1070                 1075                 1080             


Val Gly  Pro Glu Phe Ser Ala  Ser Ile Ile Gln Met  Cys Gly Val 
    1085                 1090                 1095             


Met Leu  Ser Gly Ser Glu Glu  Ser Thr Pro Ser Ile  Ile Tyr His 
    1100                 1105                 1110             


Cys Ala  Leu Arg Gly Leu Glu  Arg Leu Leu Leu Ser  Glu Gln Leu 
    1115                 1120                 1125             


Ser Arg  Leu Asp Ala Glu Ser  Leu Val Lys Leu Ser  Val Asp Arg 
    1130                 1135                 1140             


Val Asn  Val His Ser Pro His  Arg Ala Met Ala Ala  Leu Gly Leu 
    1145                 1150                 1155             


Met Leu  Thr Cys Met Tyr Thr  Gly Lys Glu Lys Val  Ser Pro Gly 
    1160                 1165                 1170             


Arg Thr  Ser Asp Pro Asn Pro  Ala Ala Pro Asp Ser  Glu Ser Val 
    1175                 1180                 1185             


Ile Val  Ala Met Glu Arg Val  Ser Val Leu Phe Asp  Arg Ile Arg 
    1190                 1195                 1200             


Lys Gly  Phe Pro Cys Glu Ala  Arg Val Val Ala Arg  Ile Leu Pro 
    1205                 1210                 1215             


Gln Phe  Leu Asp Asp Phe Phe  Pro Pro Gln Asp Ile  Met Asn Lys 
    1220                 1225                 1230             


Val Ile  Gly Glu Phe Leu Ser  Asn Gln Gln Pro Tyr  Pro Gln Phe 
    1235                 1240                 1245             


Met Ala  Thr Val Val Tyr Lys  Val Phe Gln Thr Leu  His Ser Thr 
    1250                 1255                 1260             


Gly Gln  Ser Ser Met Val Arg  Asp Trp Val Met Leu  Ser Leu Ser 
    1265                 1270                 1275             


Asn Phe  Thr Gln Arg Ala Pro  Val Ala Met Ala Thr  Trp Ser Leu 
    1280                 1285                 1290             


Ser Cys  Phe Phe Val Ser Ala  Ser Thr Ser Pro Trp  Val Ala Ala 
    1295                 1300                 1305             


Ile Leu  Pro His Val Ile Ser  Arg Met Gly Lys Leu  Glu Gln Val 
    1310                 1315                 1320             


Asp Val  Asn Leu Phe Cys Leu  Val Ala Thr Asp Phe  Tyr Arg His 
    1325                 1330                 1335             


Gln Ile  Glu Glu Glu Leu Asp  Arg Arg Ala Phe Gln  Ser Val Leu 
    1340                 1345                 1350             


Glu Val  Val Ala Ala Pro Gly  Ser Pro Tyr His Arg  Leu Leu Thr 
    1355                 1360                 1365             


Cys Leu  Arg Asn Val His Lys  Val Thr Thr Cys 
    1370                 1375                 

<210>  1880
<211>  14554
<212>  DNA
<213>  Homo sapiens

<400>  1880
gaaccctcct gcttgttctc ttgttatcta atacccctat tgacagcgca gcttagatca     60

ttaatggaga gcttgacctc atctgatacc ttcactgaag gaaacaactt agtgtctttt    120

gtgttgaaca ctgaggtaaa aaattggaat agttgattat atgaactctg ctaaaattga    180

gtgcatttta cattttttaa ggccttgttg ggccctggtt aaataattat ttttaaaaat    240

ccttaaggag cctattataa acagatctgt ggtcttaatg aaatgtgatt aatactgtgc    300

attattttaa gaacttttga cttttcaaaa aacttttaca acatttccca tttgatagcg    360

gcataggttt aagcacttct catctctaag ttagtggaca aaaaaccctc atggatagtc    420

taataatgtt tgctacaagt ccatgttgag ttttatactc cattttattt tcagttttaa    480

aaactgtggt taaatatgtg taacataaaa tttatgttct taaccatttt ttgcgtatac    540

agttcgctgg tattaaatac atttaaataa tgtcatggaa tcattgctac cacccatctc    600

tgtaaccttt tgatcatgta acactgaagc tctgttccca ttgaactcta ttcctccttt    660

cccgccaagt ccctggcaac cacgattctt ctttctgtct tctgaatttg actactttgg    720

gttctcatat actttaggag tcacacagta tttgttttac ttagcataat gtccccaaag    780

ctcatgcatg ttgtagccta tgttagaact tcctaatgtt tcaggccaaa tactattcca    840

ttgtatggat aggccacatt ttgcttttcc attcctctgt ccatggacac ttgtattgct    900

tcatgtttta gccattgtga atcatgctgt tatgaacgtg ggtgtacaga tagctcctgg    960

agactctgct ttccattttt ttggctaaat acccagaaat ggagttgctt ttacattcca   1020

attttaattt aaaacattca tatcattgag tgttttactt aatagtatag tagttaacaa   1080

acttaataaa atagtatttt ggtaataatt tgctggtagt ccattgttca gtttttttag   1140

gtaaattaca caggacattt caagtggaca tgaaacatct tgtgatgtgg aatcatgccc   1200

caagctgatg gctaaacata tgaaatacca taccctaaat ttagtagatt tagtctttgc   1260

aatttaggag ataacctgtt atattgttag gtttttgtcg aaaagctttg tcctcatatt   1320

tccaacttgc tgtaaaattt gtttgtgaag acaaatattt ttgtatgggt tttttctttt   1380

tcatattaaa aagaaatgtc cacattggaa tttttttgga gtttttagag ctaatagagc   1440

ttttcataat gtagtgggaa tgagtgatca gtaagctctt agcagtttcc atgcgtgcat   1500

ttctgtgcct tgaaataaat gacagatgag tacatttgtg ttctgtgtgt aaaatgtgct   1560

ctttcctcat tgcacttcca tgttggaggg cttgtctctt ggtgatcaca cttcaaaatt   1620

ctcacagccc cccttgaacc gtttaggtgt tagacggtac cgacaaccag tatttgggcc   1680

tgcagattgg acagccccag gatgaagatg aggaagccac aggtattctt cctgatgaag   1740

cctcggaggc cttcaggaac tcttccatgg gtatgtggac tacaggtgat gcgctacaaa   1800

gtggtttgta ttcagacctg gacatcttaa ttatatcttt gcttccaaga agaagtcctt   1860

tgatactgtt ttctgagttc tgaatagctg atgaaaatga ccaattgagg aataatcata   1920

ctttttcttg atctaaatct tatacttttg agttatctta gcataaatgt ataattgtat   1980

tttaagtgga aatttgtcac ttaatcttga tttctctgtt tttaaagccc ttcaacaggc   2040

acatttattg aaaaacatga gtcactgcag gcagccttct gacagcagtg ttgataaatt   2100

tgtgttgaga gatgaagcta ctgaaccggg tgatcaagaa aacaagcctt gccgcatcaa   2160

aggtgacatt ggacagtcca ctgatgatga ctctgcacct cttgtccatt gtgtccgcct   2220

tttatctgct tcgtttttgc taacaggggg aaaaaatgtg ctggttccgg acagggatgt   2280

gagggtcagc gtgaaggccc tggccctcag ctgtgtggga gcagctgtgg ccctccaccc   2340

ggaatctttc ttcagcaaac tctataaagt tcctcttgac accacggaat accctgagga   2400

acagtatgtc tcagacatct tgaactacat cgatcatgga gacccacagg ttcgaggagc   2460

cactgccatt ctctgtggga ccctcatctg ctccatcctc agcaggtccc gcttccacgt   2520

gggagattgg atgggcacca ttagaaccct cacaggaaat acattttctt tggcggattg   2580

cattcctttg ctgcggaaaa cactgaagga tgagtcttct gttacttgca agttagcttg   2640

tacagctgtg aggaactgtg tcatgagtct ctgcagcagc agctacagtg agttaggact   2700

gcagctgatc atcgatgtgc tgactctgag gaacagttcc tattggctgg tgaggacaga   2760

gcttctggaa acccttgcag agattgactt caggctggtg agctttttgg aggcaaaagc   2820

agaaaactta cacagagggg ctcatcatta tacagggctt ttaaaactgc aagaacgagt   2880

gctcaataat gttgtcatcc atttgcttgg agatgaagac cccagggtgc gacatgttgc   2940

cgcagcatca ctaattaggc ttgtcccaaa gctgttttat aaatgtgacc aaggacaagc   3000

tgatccagta gtggccgtgg caagagatca aagcagtgtt tacctgaaac ttctcatgca   3060

tgagacgcag cctccatctc atttctccgt cagcacaata accagaatat atagaggcta   3120

taacctacta ccaagcataa cagacgtcac tatggaaaat aacctttcaa gagttattgc   3180

agcagtttct catgaactaa tcacatcaac caccagagca ctcacatttg gatgctgtga   3240

agctttgtgt cttctttcca ctgccttccc agtttgcatt tggagtttag gttggcactg   3300

tggagtgcct ccactgagtg cctcagatga gtctaggaag agctgtaccg ttgggatggc   3360

cacaatgatt ctgaccctgc tctcgtcagc ttggttccca ttggatctct cagcccatca   3420

agatgctttg attttggccg gaaacttgct tgcagccagt gctcccaaat ctctgagaag   3480

ttcatgggcc tctgaagaag aagccaaccc agcagccacc aagcaagagg aggtctggcc   3540

agccctgggg gaccgggccc tggtgcccat ggtggagcag ctcttctctc acctgctgaa   3600

ggtgattaac atttgtgccc acgtcctgga tgacgtggct cctggacccg caataaaggc   3660

agccttgcct tctctaacaa accccccttc tctaagtccc atccgacgaa aggggaagga   3720

gaaagaacca ggagaacaag catctgtacc gttgagtccc aagaaaggca gtgaggccag   3780

tgcagcttct agacaatctg atacctcagg tcctgttaca acaagtaaat cctcatcact   3840

ggggagtttc tatcatcttc cttcatacct caaactgcat gatgtcctga aagctacaca   3900

cgctaactac aaggtcacgc tggatcttca gaacagcacg gaaaagtttg gagggtttct   3960

ccgctcagcc ttggatgttc tttctcagat actagagctg gccacactgc aggacattgg   4020

gaagtgtgtt gaagagatcc taggatacct gaaatcctgc tttagtcgag aaccaatgat   4080

ggcaactgtt tgtgttcaac aattgttgaa gactctcttt ggcacaaact tggcctccca   4140

gtttgatggc ttatcttcca accccagcaa gtcacaaggc cgagcacagc gccttggctc   4200

ctccagtgtg aggccaggct tgtaccacta ctgcttcatg gccccgtaca cccacttcac   4260

ccaggccctc gctgacgcca gcctgaggaa catggtgcag gcggagcagg agaacgacac   4320

ctcgggatgg tttgatgtcc tccagaaagt gtctacccag ttgaagacaa acctcacgag   4380

tgtcacaaag aaccgtgcag ataagaatgc tattcataat cacattcgtt tgtttgaacc   4440

tcttgttata aaagctttaa aacagtacac gactacaaca tgtgtgcagt tacagaagca   4500

ggttttagat ttgctggcgc agctggttca gttacgggtt aattactgtc ttctggattc   4560

agatcaggtg tttattggct ttgtattgaa acagtttgaa tacattgaag tgggccagtt   4620

cagggaatca gaggcaatca ttccaaacat ctttttcttc ttggtattac tatcttatga   4680

acgctatcat tcaaaacaga tcattggaat tcctaaaatc attcagctct gtgatggcat   4740

catggccagt ggaaggaagg ctgtgacaca tgccataccg gctctgcagc ccatagtcca   4800

cgacctcttt gtattaagag gaacaaataa agctgatgca ggaaaagagc ttgaaaccca   4860

aaaagaggtg gtggtgtcaa tgttactgag actcatccag taccatcagg tgttggagat   4920

gttcattctt gtcctgcagc agtgccacaa ggagaatgaa gacaagtgga agcgactgtc   4980

tcgacagata gctgacatca tcctcccaat gttagccaaa cagcagatgc acattgactc   5040

tcatgaagcc cttggagtgt taaatacatt atttgagatt ttggcccctt cctccctccg   5100

tccggtagac atgcttttac ggagtatgtt cgtcactcca aacacaatgg cgtccgtgag   5160

cactgttcaa ctgtggatat cgggaattct ggccattttg agggttctga tttcccagtc   5220

aactgaagat attgttcttt ctcgtattca ggagctctcc ttctctccgt atttaatctc   5280

ctgtacagta attaataggt taagagatgg ggacagtact tcaacgctag aagaacacag   5340

tgaagggaaa caaataaaga atttgccaga agaaacattt tcaaggtatg ctttctatct   5400

gagcctataa ctaacccatg ccttttggga agtcacgtga tgtttcacag tcagtaagtc   5460

tggaataata cctggtcttg cttcacttct gagttgggta aagaagtctg tatcagtgta   5520

attttctaat ccgtcctgca ttatctatgg ctcttggttc atacctgtct tgaagttctg   5580

tcatgttctg tctcttgtcc tcagtagaga tgctacagca gtggctcgcc tcaggcaggg   5640

cagggcagtg gggtggctgt cctgggggca ggcagtaggg gcacgctgac gtcagggaag   5700

ttgaaaccca agagaagcca gtaaaagtga gtctcagatt gtcaccatgt gctggcagtt   5760

ttacacgctg tcagtaataa aagtcttctc cctgcagggc agcctgcctc caataaatac   5820

gtgtagtatc aaatcctgtc ttccctcata aattgtttgg aagctcccca aggacagtga   5880

tgaggcactc gtaagtgctt gctgcctaga tgggtccctc tccacctttg ctagattctg   5940

agcattcact gagttagagc tgcttctgca aatgtgctgc ttctgctaag tggctgtgac   6000

ttcatgcagc cttcacttgg tttgtcatca gtggagatgc cctgtgttgt cgaaggagat   6060

aagcccagta agcctgctgg gcaccttttg gtttgcaggt tcagcaggca gcccatggct   6120

ttccctgtgt cgcattgaag cagctggcta aaattgatga tacattaaat tcctgtgaca   6180

gatgatcagc ttgtatttgt gtaatggtgt acagttcaca aagcttaaaa aaatgctacc   6240

tgccatttca tcctcagtga ggaaggtgat acacagagag accaagtgac tgtgtccacg   6300

gcgacggcgc tctgcatttc actttagcgg ttaatgtact ctacctatat ttttacttta   6360

tatttaccat atatcttttc atgtatactt ggcgtaagtg ctttatagta gtcacctaat   6420

tcactgtcat cttttttgtt tcttggaagg tttctattac aactggttgg tattctttta   6480

gaagacattg ttacaaaaca gctgaaggtg gaaatgagtg agcagcaaca tactttctat   6540

tgccaggaac taggcacact gctaatgtgt ctgatccaca tcttcaagtc tggaatgttc   6600

cggagaatca cagcagctgc cactaggctg ttccgcagtg atggctgtgg cggcagtttc   6660

tacaccctgg acagcttgaa cttgcgggct cgttccatga tcaccaccca cccggccctg   6720

gtgctgctct ggtgtcagat actgctgctt gtcaaccaca ccgactaccg ctggtgggca   6780

gaagtgcagc agaccccgaa aagacacagt ctgtccagca caaagttact tagtccccag   6840

atgtctggag aagaggagga ttctgacttg gcagccaaac ttggaatgtg caatagagaa   6900

atagtacgaa gaggggctct cattctcttc tgtgattatg tctgtcagaa cctccatgac   6960

tccgagcact taacgtggct cattgtaaat cacattcaag atctgatcag cctttcccac   7020

gagcctccag tacaggactt catcagtgcc gttcatcgga actctgctgc cagcggcctg   7080

ttcatccagg caattcagtc tcgttgtgaa aacctttcaa ctccaaccat gctgaagaaa   7140

actcttcagt gcttggaggg gatccatctc agccagtcgg gagctgtgct cacgctgtat   7200

gtggacaggc ttctgtgcac ccctttccgt gtgctggctc gcatggtcga catccttgct   7260

tgtcgccggg tagaaatgct tctggctgca aatttacaga gcagcatggc ccagttgcca   7320

atggaagaac tcaacagaat ccaggaatac cttcagagca gcgggctcgc tcagagacac   7380

caaaggctct attccctgct ggacaggttt cgtctctcca ccatgcaaga ctcacttagt   7440

ccctctcctc cagtctcttc ccacccgctg gacggggatg ggcacgtgtc actggaaaca   7500

gtgagtccgg acaaagactg gtacgttcat cttgtcaaat cccagtgttg gaccaggtca   7560

gattctgcac tgctggaagg tgcagagctg gtgaatcgga ttcctgctga agatatgaat   7620

gccttcatga tgaactcgga gttcaaccta agcctgctag ctccatgctt aagcctaggg   7680

atgagtgaaa tttctggtgg ccagaagagt gccctttttg aagcagcccg tgaggtgact   7740

ctggcccgtg tgagcggcac cgtgcagcag ctccctgctg tccatcatgt cttccagccc   7800

gagctgcctg cagagccggc ggcctactgg agcaagttga atgatctgtt tggggatgct   7860

gcactgtatc agtccctgcc cactctggcc cgggccctgg cacagtacct ggtggtggtc   7920

tccaaactgc ccagtcattt gcaccttcct cctgagaaag agaaggacat tgtgaaattc   7980

gtggtggcaa cccttgaggc cctgtcctgg catttgatcc atgagcagat cccgctgagt   8040

ctggatctcc aggcagggct ggactgctgc tgcctggccc tgcagctgcc tggcctctgg   8100

agcgtggtct cctccacaga gtttgtgacc cacgcctgct ccctcatcta ctgtgtgcac   8160

ttcatcctgg aggccgttgc agtgcagcct ggagagcagc ttcttagtcc agaaagaagg   8220

acaaataccc caaaagccat cagcgaggag gaggaggaag tagatccaaa cacacagaat   8280

cctaagtata tcactgcagc ctgtgagatg gtggcagaaa tggtggagtc tctgcagtcg   8340

gtgttggcct tgggtcataa aaggaatagc ggcgtgccgg cgtttctcac gccattgcta   8400

aggaacatca tcatcagcct ggcccgcctg ccccttgtca acagctacac acgtgtgccc   8460

ccactggtgt ggaagcttgg atggtcaccc aaaccgggag gggattttgg cacagcattc   8520

cctgagatcc ccgtggagtt cctccaggaa aaggaagtct ttaaggagtt catctaccgc   8580

atcaacacac taggctggac cagtcgtact cagtttgaag aaacttgggc caccctcctt   8640

ggtgtcctgg tgacgcagcc cctcgtgatg gagcaggagg agagcccacc agaagaagac   8700

acagagagga cccagatcaa cgtcctggcc gtgcaggcca tcacctcact ggtgctcagt   8760

gcaatgactg tgcctgtggc cggcaaccca gctgtaagct gcttggagca gcagccccgg   8820

aacaagcctc tgaaagctct cgacaccagg tttgggagga agctgagcat tatcagaggg   8880

attgtggagc aagagattca agcaatggtt tcaaagagag agaatattgc cacccatcat   8940

ttatatcagg catgggatcc tgtcccttct ctgtctccgg ctactacagg tgccctcatc   9000

agccacgaga agctgctgct acagatcaac cccgagcggg agctggggag catgagctac   9060

aaactcggcc aggtgtccat acactccgtg tggctgggga acagcatcac acccctgagg   9120

gaggaggaat gggacgagga agaggaggag gaggccgacg cccctgcacc ttcgtcacca   9180

cccacgtctc cagtcaactc caggaaacac cgggctggag ttgacatcca ctcctgttcg   9240

cagtttttgc ttgagttgta cagccgctgg atcctgccgt ccagctcagc caggaggacc   9300

ccggccatcc tgatcagtga ggtggtcaga tcccttctag tggtctcaga cttgttcacc   9360

gagcgcaacc agtttgagct gatgtatgtg acgctgacag aactgcgaag ggtgcaccct   9420

tcagaagacg agatcctcgc tcagtacctg gtgcctgcca cctgcaaggc agctgccgtc   9480

cttgggatgg acaaggccgt ggcggagcct gtcagccgcc tgctggagag cacgctcagg   9540

agcagccacc tgcccagcag ggttggagcc ctgcacggcg tcctctatgt gctggagtgc   9600

gacctgctgg acgacactgc caagcagctc atcccggtca tcagcgacta tctcctctcc   9660

aacctgaaag ggatcgccca ctgcgtgaac attcacagcc agcagcacgt actggtcatg   9720

tgtgccactg cgttttacct cattgagaac tatcctctgg acgtagggcc ggaattttca   9780

gcatcaataa tacagatgtg tggggtgatg ctgtctggaa gtgaggagtc caccccctcc   9840

atcatttacc actgtgccct cagaggcctg gagcgcctcc tgctctctga gcagctctcc   9900

cgcctggatg cagaatcgct ggtcaagctg agtgtggaca gagtgaacgt gcacagcccg   9960

caccgggcca tggcggctct gggcctgatg ctcacctgca tgtacacagg aaaggagaaa  10020

gtcagtccgg gtagaacttc agaccctaat cctgcagccc ccgacagcga gtcagtgatt  10080

gttgctatgg agcgggtatc tgttcttttt gataggatca ggaaaggctt tccttgtgaa  10140

gccagagtgg tggccaggat cctgccccag tttctagacg acttcttccc accccaggac  10200

atcatgaaca aagtcatcgg agagtttctg tccaaccagc agccataccc ccagttcatg  10260

gccaccgtgg tgtataaggt gtttcagact ctgcacagca ccgggcagtc gtccatggtc  10320

cgggactggg tcatgctgtc cctctccaac ttcacgcaga gggccccggt cgccatggcc  10380

acgtggagcc tctcctgctt ctttgtcagc gcgtccacca gcccgtgggt cgcggcgatc  10440

ctcccacatg tcatcagcag gatgggcaag ctggagcagg tggacgtgaa ccttttctgc  10500

ctggtcgcca cagacttcta cagacaccag atagaggagg agctcgaccg cagggccttc  10560

cagtctgtgc ttgaggtggt tgcagcccca ggaagcccat atcaccggct gctgacttgt  10620

ttacgaaatg tccacaaggt caccacctgc tgagcgccat ggtgggagag actgtgaggc  10680

ggcagctggg gccggagcct ttggaagtct gcgcccttgt gccctgcctc caccgagcca  10740

gcttggtccc tatgggcttc cgcacatgcc gcgggcggcc aggcaacgtg cgtgtctctg  10800

ccatgtggca gaagtgctct ttgtggcagt ggccaggcag ggagtgtctg cagtcctggt  10860

ggggctgagc ctgaggcctt ccagaaagca ggagcagctg tgctgcaccc catgtgggtg  10920

accaggtcct ttctcctgat agtcacctgc tggttgttgc caggttgcag ctgctcttgc  10980

atctgggcca gaagtcctcc ctcctgcagg ctggctgttg gcccctctgc tgtcctgcag  11040

tagaaggtgc cgtgagcagg ctttgggaac actggcctgg gtctccctgg tggggtgtgc  11100

atgccacgcc ccgtgtctgg atgcacagat gccatggcct gtgctgggcc agtggctggg  11160

ggtgctagac acccggcacc attctccctt ctctcttttc ttctcaggat ttaaaattta  11220

attatatcag taaagagatt aattttaacg taactctttc tatgcccgtg taaagtatgt  11280

gaatcgcaag gcctgtgctg catgcgacag cgtccggggt ggtggacagg gcccccggcc  11340

acgctccctc tcctgtagcc actggcatag ccctcctgag cacccgctga catttccgtt  11400

gtacatgttc ctgtttatgc attcacaagg tgactgggat gtagagaggc gttagtgggc  11460

aggtggccac agcaggactg aggacaggcc cccattatcc taggggtgcg ctcacctgca  11520

gcccctcctc ctcgggcaca gacgactgtc gttctccacc caccagtcag ggacagcagc  11580

ctccctgtca ctcagctgag aaggccagcc ctccctggct gtgagcagcc tccactgtgt  11640

ccagagacat gggcctccca ctcctgttcc ttgctagccc tggggtggcg tctgcctagg  11700

agctggctgg caggtgttgg gacctgctgc tccatggatg catgccctaa gagtgtcact  11760

gagctgtgtt ttgtctgagc ctctctcggt caacagcaaa gcttggtgtc ttggcactgt  11820

tagtgacaga gcccagcatc ccttctgccc ccgttccagc tgacatcttg cacggtgacc  11880

ccttttagtc aggagagtgc agatctgtgc tcatcggaga ctgccccacg gccctgtcag  11940

agccgccact cctatcccca ggccaggtcc ctggaccagc ctcctgtttg caggcccaga  12000

ggagccaagt cattaaaatg gaagtggatt ctggatggcc gggctgctgc tgatgtagga  12060

gctggatttg ggagctctgc ttgccgactg gctgtgagac gaggcagggg ctctgcttcc  12120

tcagccctag aggcgagcca ggcaaggttg gcgactgtca tgtggcttgg tttggtcatg  12180

cccgtcgatg ttttgggtat tgaatgtggt aagtggagga aatgttggaa ctctgtgcag  12240

gtgctgcctt gagaccccca agcttccacc tgtccctctc ctatgtggca gctggggagc  12300

agctgagatg tggacttgta tgctgcccac atacgtgagg gggagctgaa agggagcccc  12360

tcctctgagc agcctctgcc aggcctgtat gaggcttttc ccaccagctc ccaacagagg  12420

cctcccccag ccaggaccac ctcgtcctcg tggcggggca gcaggagcgg tagaaagggg  12480

tccgatgttt gaggaggccc ttaagggaag ctactgaatt ataacacgta agaaaatcac  12540

cattccgtat tggttggggg ctcctgtttc tcatcctagc tttttcctgg aaagcccgct  12600

agaaggtttg ggaacgaggg gaaagttctc agaactgttg gctgctcccc acccgcctcc  12660

cgcctccccc gcaggttatg tcagcagctc tgagacagca gtatcacagg ccagatgttg  12720

ttcctggcta gatgtttaca tttgtaagaa ataacactgt gaatgtaaaa cagagccatt  12780

cccttggaat gcatatcgct gggctcaaca tagagtttgt cttcctcttg tttacgacgt  12840

gatctaaacc agtccttagc aaggggctca gaacaccccg ctctggcagt aggtgtcccc  12900

cacccccaaa gacctgcctg tgtgctccgg agatgaatat gagctcatta gtaaaaatga  12960

cttcacccac gcatatacat aaagtatcca tgcatgtgca tatagacaca tctataattt  13020

tacacacaca cctctcaaga cggagatgca tggcctctaa gagtgcccgt gtcggttctt  13080

cctggaagtt gactttcctt agacccgcca ggtcaagtta gccgcgtgac ggacatccag  13140

gcgtgggacg tggtcagggc agggctcatt cattgcccac taggatccca ctggcgaaga  13200

tggtctccat atcagctctc tgcagaaggg aggaagactt tatcatgttc ctaaaaatct  13260

gtggcaagca cccatcgtat tatccaaatt ttgttgcaaa tgtgattaat ttggttgtca  13320

agttttgggg gtgggctgtg gggagattgc ttttgttttc ctgctggtaa tatcgggaaa  13380

gattttaatg aaaccagggt agaattgttt ggcaatgcac tgaagcgtgt ttctttccca  13440

aaatgtgcct cccttccgct gcgggcccag ctgagtctat gtaggtgatg tttccagctg  13500

ccaagtgctc tttgttactg tccaccctca tttctgccag cgcatgtgtc ctttcaaggg  13560

gaaaatgtga agctgaaccc cctccagaca cccagaatgt agcatctgag aaggccctgt  13620

gccctaaagg acacccctcg cccccatctt catggagggg gtcatttcag agccctcgga  13680

gccaatgaac agctcctcct cttggagctg agatgagccc cacgtggagc tcgggacgga  13740

tagtagacag caataactcg gtgtgtggcc gcctggcagg tggaacttcc tcccgttgcg  13800

gggtggagtg aggttagttc tgtgtgtctg gtgggtggag tcaggcttct cttgctacct  13860

gtgagcatcc ttcccagcag acatcctcat cgggctttgt ccctcccccg cttcctccct  13920

ctgcggggag gacccgggac cacagctgct ggccagggta gacttggagc tgtcctccag  13980

aggggtcacg tgtaggagtg agaagaagga agatcttgag agctgctgag ggaccttgga  14040

gagctcagga tggctcagac gaggacactc gcttgccggg cctgggcctc ctgggaagga  14100

gggagctgct cagaatgccg catgacaact gaaggcaacc tggaaggttc aggggccgct  14160

cttcccccat gtgcctgtca cgctctggtg cagtcaaagg aacgccttcc cctcagttgt  14220

ttctaagagc agagtctccc gctgcaatct gggtggtaac tgccagcctt ggaggatcgt  14280

ggccaacgtg gacctgccta cggagggtgg gctctgaccc aagtggggcc tccttgtcca  14340

ggtctcactg ctttgcaccg tggtcagagg gactgtcagc tgagcttgag ctcccctgga  14400

gccagcaggg ctgtgatggg cgagtcccgg agccccaccc agacctgaat gcttctgaga  14460

gcaaagggaa ggactgacga gagatgtata tttaattttt taactgctgc aaacattgta  14520

catccaaatt aaaggaaaaa aatggaaacc atca                              14554


<210>  1881
<211>  1379
<212>  PRT
<213>  Homo sapiens

<400>  1881


Met Ser Glu Gln Gln His Thr Phe Tyr Cys Gln Glu Leu Gly Thr Leu 
1               5                   10                  15      


Leu Met Cys Leu Ile His Ile Phe Lys Ser Gly Met Phe Arg Arg Ile 
            20                  25                  30          


Thr Ala Ala Ala Thr Arg Leu Phe Arg Ser Asp Gly Cys Gly Gly Ser 
        35                  40                  45              


Phe Tyr Thr Leu Asp Ser Leu Asn Leu Arg Ala Arg Ser Met Ile Thr 
    50                  55                  60                  


Thr His Pro Ala Leu Val Leu Leu Trp Cys Gln Ile Leu Leu Leu Val 
65                  70                  75                  80  


Asn His Thr Asp Tyr Arg Trp Trp Ala Glu Val Gln Gln Thr Pro Lys 
                85                  90                  95      


Arg His Ser Leu Ser Ser Thr Lys Leu Leu Ser Pro Gln Met Ser Gly 
            100                 105                 110         


Glu Glu Glu Asp Ser Asp Leu Ala Ala Lys Leu Gly Met Cys Asn Arg 
        115                 120                 125             


Glu Ile Val Arg Arg Gly Ala Leu Ile Leu Phe Cys Asp Tyr Val Cys 
    130                 135                 140                 


Gln Asn Leu His Asp Ser Glu His Leu Thr Trp Leu Ile Val Asn His 
145                 150                 155                 160 


Ile Gln Asp Leu Ile Ser Leu Ser His Glu Pro Pro Val Gln Asp Phe 
                165                 170                 175     


Ile Ser Ala Val His Arg Asn Ser Ala Ala Ser Gly Leu Phe Ile Gln 
            180                 185                 190         


Ala Ile Gln Ser Arg Cys Glu Asn Leu Ser Thr Pro Thr Met Leu Lys 
        195                 200                 205             


Lys Thr Leu Gln Cys Leu Glu Gly Ile His Leu Ser Gln Ser Gly Ala 
    210                 215                 220                 


Val Leu Thr Leu Tyr Val Asp Arg Leu Leu Cys Thr Pro Phe Arg Val 
225                 230                 235                 240 


Leu Ala Arg Met Val Asp Ile Leu Ala Cys Arg Arg Val Glu Met Leu 
                245                 250                 255     


Leu Ala Ala Asn Leu Gln Ser Ser Met Ala Gln Leu Pro Met Glu Glu 
            260                 265                 270         


Leu Asn Arg Ile Gln Glu Tyr Leu Gln Ser Ser Gly Leu Ala Gln Arg 
        275                 280                 285             


His Gln Arg Leu Tyr Ser Leu Leu Asp Arg Phe Arg Leu Ser Thr Met 
    290                 295                 300                 


Gln Asp Ser Leu Ser Pro Ser Pro Pro Val Ser Ser His Pro Leu Asp 
305                 310                 315                 320 


Gly Asp Gly His Val Ser Leu Glu Thr Val Ser Pro Asp Lys Asp Trp 
                325                 330                 335     


Tyr Val His Leu Val Lys Ser Gln Cys Trp Thr Arg Ser Asp Ser Ala 
            340                 345                 350         


Leu Leu Glu Gly Ala Glu Leu Val Asn Arg Ile Pro Ala Glu Asp Met 
        355                 360                 365             


Asn Ala Phe Met Met Asn Ser Glu Phe Asn Leu Ser Leu Leu Ala Pro 
    370                 375                 380                 


Cys Leu Ser Leu Gly Met Ser Glu Ile Ser Gly Gly Gln Lys Ser Ala 
385                 390                 395                 400 


Leu Phe Glu Ala Ala Arg Glu Val Thr Leu Ala Arg Val Ser Gly Thr 
                405                 410                 415     


Val Gln Gln Leu Pro Ala Val His His Val Phe Gln Pro Glu Leu Pro 
            420                 425                 430         


Ala Glu Pro Ala Ala Tyr Trp Ser Lys Leu Asn Asp Leu Phe Gly Asp 
        435                 440                 445             


Ala Ala Leu Tyr Gln Ser Leu Pro Thr Leu Ala Arg Ala Leu Ala Gln 
    450                 455                 460                 


Tyr Leu Val Val Val Ser Lys Leu Pro Ser His Leu His Leu Pro Pro 
465                 470                 475                 480 


Glu Lys Glu Lys Asp Ile Val Lys Phe Val Val Ala Thr Leu Glu Ala 
                485                 490                 495     


Leu Ser Trp His Leu Ile His Glu Gln Ile Pro Leu Ser Leu Asp Leu 
            500                 505                 510         


Gln Ala Gly Leu Asp Cys Cys Cys Leu Ala Leu Gln Leu Pro Gly Leu 
        515                 520                 525             


Trp Ser Val Val Ser Ser Thr Glu Phe Val Thr His Ala Cys Ser Leu 
    530                 535                 540                 


Ile Tyr Cys Val His Phe Ile Leu Glu Ala Val Ala Val Gln Pro Gly 
545                 550                 555                 560 


Glu Gln Leu Leu Ser Pro Glu Arg Arg Thr Asn Thr Pro Lys Ala Ile 
                565                 570                 575     


Ser Glu Glu Glu Glu Glu Val Asp Pro Asn Thr Gln Asn Pro Lys Tyr 
            580                 585                 590         


Ile Thr Ala Ala Cys Glu Met Val Ala Glu Met Val Glu Ser Leu Gln 
        595                 600                 605             


Ser Val Leu Ala Leu Gly His Lys Arg Asn Ser Gly Val Pro Ala Phe 
    610                 615                 620                 


Leu Thr Pro Leu Leu Arg Asn Ile Ile Ile Ser Leu Ala Arg Leu Pro 
625                 630                 635                 640 


Leu Val Asn Ser Tyr Thr Arg Val Pro Pro Leu Val Trp Lys Leu Gly 
                645                 650                 655     


Trp Ser Pro Lys Pro Gly Gly Asp Phe Gly Thr Ala Phe Pro Glu Ile 
            660                 665                 670         


Pro Val Glu Phe Leu Gln Glu Lys Glu Val Phe Lys Glu Phe Ile Tyr 
        675                 680                 685             


Arg Ile Asn Thr Leu Gly Trp Thr Ser Arg Thr Gln Phe Glu Glu Thr 
    690                 695                 700                 


Trp Ala Thr Leu Leu Gly Val Leu Val Thr Gln Pro Leu Val Met Glu 
705                 710                 715                 720 


Gln Glu Glu Ser Pro Pro Glu Glu Asp Thr Glu Arg Thr Gln Ile Asn 
                725                 730                 735     


Val Leu Ala Val Gln Ala Ile Thr Ser Leu Val Leu Ser Ala Met Thr 
            740                 745                 750         


Val Pro Val Ala Gly Asn Pro Ala Val Ser Cys Leu Glu Gln Gln Pro 
        755                 760                 765             


Arg Asn Lys Pro Leu Lys Ala Leu Asp Thr Arg Phe Gly Arg Lys Leu 
    770                 775                 780                 


Ser Ile Ile Arg Gly Ile Val Glu Gln Glu Ile Gln Ala Met Val Ser 
785                 790                 795                 800 


Lys Arg Glu Asn Ile Ala Thr His His Leu Tyr Gln Ala Trp Asp Pro 
                805                 810                 815     


Val Pro Ser Leu Ser Pro Ala Thr Thr Gly Ala Leu Ile Ser His Glu 
            820                 825                 830         


Lys Leu Leu Leu Gln Ile Asn Pro Glu Arg Glu Leu Gly Ser Met Ser 
        835                 840                 845             


Tyr Lys Leu Gly Gln Val Ser Ile His Ser Val Trp Leu Gly Asn Ser 
    850                 855                 860                 


Ile Thr Pro Leu Arg Glu Glu Glu Trp Asp Glu Glu Glu Glu Glu Glu 
865                 870                 875                 880 


Ala Asp Ala Pro Ala Pro Ser Ser Pro Pro Thr Ser Pro Val Asn Ser 
                885                 890                 895     


Arg Lys His Arg Ala Gly Val Asp Ile His Ser Cys Ser Gln Phe Leu 
            900                 905                 910         


Leu Glu Leu Tyr Ser Arg Trp Ile Leu Pro Ser Ser Ser Ala Arg Arg 
        915                 920                 925             


Thr Pro Ala Ile Leu Ile Ser Glu Val Val Arg Ser Leu Leu Val Val 
    930                 935                 940                 


Ser Asp Leu Phe Thr Glu Arg Asn Gln Phe Glu Leu Met Tyr Val Thr 
945                 950                 955                 960 


Leu Thr Glu Leu Arg Arg Val His Pro Ser Glu Asp Glu Ile Leu Ala 
                965                 970                 975     


Gln Tyr Leu Val Pro Ala Thr Cys Lys Ala Ala Ala Val Leu Gly Met 
            980                 985                 990         


Asp Lys Ala Val Ala Glu Pro Val  Ser Arg Leu Leu Glu  Ser Thr Leu 
        995                 1000                 1005             


Arg Ser  Ser His Leu Pro Ser  Arg Val Gly Ala Leu  His Gly Val 
    1010                 1015                 1020             


Leu Tyr  Val Leu Glu Cys Asp  Leu Leu Asp Asp Thr  Ala Lys Gln 
    1025                 1030                 1035             


Leu Ile  Pro Val Ile Ser Asp  Tyr Leu Leu Ser Asn  Leu Lys Gly 
    1040                 1045                 1050             


Ile Ala  His Cys Val Asn Ile  His Ser Gln Gln His  Val Leu Val 
    1055                 1060                 1065             


Met Cys  Ala Thr Ala Phe Tyr  Leu Ile Glu Asn Tyr  Pro Leu Asp 
    1070                 1075                 1080             


Val Gly  Pro Glu Phe Ser Ala  Ser Ile Ile Gln Met  Cys Gly Val 
    1085                 1090                 1095             


Met Leu  Ser Gly Ser Glu Glu  Ser Thr Pro Ser Ile  Ile Tyr His 
    1100                 1105                 1110             


Cys Ala  Leu Arg Gly Leu Glu  Arg Leu Leu Leu Ser  Glu Gln Leu 
    1115                 1120                 1125             


Ser Arg  Leu Asp Ala Glu Ser  Leu Val Lys Leu Ser  Val Asp Arg 
    1130                 1135                 1140             


Val Asn  Val His Ser Pro His  Arg Ala Met Ala Ala  Leu Gly Leu 
    1145                 1150                 1155             


Met Leu  Thr Cys Met Tyr Thr  Gly Lys Glu Lys Val  Ser Pro Gly 
    1160                 1165                 1170             


Arg Thr  Ser Asp Pro Asn Pro  Ala Ala Pro Asp Ser  Glu Ser Val 
    1175                 1180                 1185             


Ile Val  Ala Met Glu Arg Val  Ser Val Leu Phe Asp  Arg Ile Arg 
    1190                 1195                 1200             


Lys Gly  Phe Pro Cys Glu Ala  Arg Val Val Ala Arg  Ile Leu Pro 
    1205                 1210                 1215             


Gln Phe  Leu Asp Asp Phe Phe  Pro Pro Gln Asp Ile  Met Asn Lys 
    1220                 1225                 1230             


Val Ile  Gly Glu Phe Leu Ser  Asn Gln Gln Pro Tyr  Pro Gln Phe 
    1235                 1240                 1245             


Met Ala  Thr Val Val Tyr Lys  Val Phe Gln Thr Leu  His Ser Thr 
    1250                 1255                 1260             


Gly Gln  Ser Ser Met Val Arg  Asp Trp Val Met Leu  Ser Leu Ser 
    1265                 1270                 1275             


Asn Phe  Thr Gln Arg Ala Pro  Val Ala Met Ala Thr  Trp Ser Leu 
    1280                 1285                 1290             


Ser Cys  Phe Phe Val Ser Ala  Ser Thr Ser Pro Trp  Val Ala Ala 
    1295                 1300                 1305             


Ile Leu  Pro His Val Ile Ser  Arg Met Gly Lys Leu  Glu Gln Val 
    1310                 1315                 1320             


Asp Val  Asn Leu Phe Cys Leu  Val Ala Thr Asp Phe  Tyr Arg His 
    1325                 1330                 1335             


Gln Ile  Glu Glu Glu Leu Asp  Arg Arg Ala Phe Gln  Ser Val Leu 
    1340                 1345                 1350             


Glu Val  Val Ala Ala Pro Gly  Ser Pro Tyr His Arg  Leu Leu Thr 
    1355                 1360                 1365             


Cys Leu  Arg Asn Val His Lys  Val Thr Thr Cys 
    1370                 1375                 

<210>  1882
<211>  373
<212>  DNA
<213>  Homo sapiens

<400>  1882
tcttatgaac gctatcattc aaaacagatc attggaattc ctaaaatcat tcagctctgt     60

gatggcatca tggccagtgg aaggaaggct gtgacacatg ccataccggc tctgcagccc    120

atagtccacg acctctttgt attaagagga acaaataaag ctgatgcagg aaaagagctt    180

gaaacccaaa aagaggtggt ggtgtcaatg ttactgagac tcatccagta ccatcaggta    240

agaggaatgt atgttggaac tgtcgtggat actttattga cccgtgcaga tggaaggaag    300

tgccatgtgg taacgctcac tgttaactgt gttactttga accaggtttg ggctttctgg    360

ggcctgggta gat                                                       373


<210>  1883
<211>  100
<212>  PRT
<213>  Homo sapiens

<400>  1883


Met Ala Ser Gly Arg Lys Ala Val Thr His Ala Ile Pro Ala Leu Gln 
1               5                   10                  15      


Pro Ile Val His Asp Leu Phe Val Leu Arg Gly Thr Asn Lys Ala Asp 
            20                  25                  30          


Ala Gly Lys Glu Leu Glu Thr Gln Lys Glu Val Val Val Ser Met Leu 
        35                  40                  45              


Leu Arg Leu Ile Gln Tyr His Gln Val Arg Gly Met Tyr Val Gly Thr 
    50                  55                  60                  


Val Val Asp Thr Leu Leu Thr Arg Ala Asp Gly Arg Lys Cys His Val 
65                  70                  75                  80  


Val Thr Leu Thr Val Asn Cys Val Thr Leu Asn Gln Val Trp Ala Phe 
                85                  90                  95      


Trp Gly Leu Gly 
            100 

<210>  1884
<211>  860
<212>  DNA
<213>  Homo sapiens

<400>  1884
gagctggtat acgatgcctc tccagaatca ccttgttctt tctggatcta ttcagaatct     60

gaaactccta gaaaagaaaa atgcaagatg catgagttga gacaggatct cactatgttg    120

ccttgcatgg actggaactc cttggctcaa gaaatcttct tgcctcagcc tcccaaatag    180

ctaggactat atgcacatgc tactacacct agtggaaaat gaagcacaga gaagttcagt    240

gatggacctc agatactacc agcagaaagc agaagagcta ggatttcaac ttaggatgtc    300

tggatccaca gtctgcactc ctacccacta tgctacactg cctctaacta tgaggaagca    360

agggcatttt tttttttctg gtgactaaaa agataagagt tcaagtatgt ggctcctgat    420

aatctaactt atacagcctg gaaaaattga tagttactat atccagactg tctcattcaa    480

ttaacagttt ctcaagtaat cttctagtta ctgtcgtatt ttatctgtat caacttagca    540

aaccaagtcc aaaacatttt atatgtgtct atctttcctg ctgttcatat tattgagtta    600

gccaaataaa ttcaattttt tttctactgt ttgtttctca caaattatga ctggcatctg    660

tatatctggg aaggttctac tgcattgctg tattatcact atataattat aagagatcac    720

agagtgcatt gatgaaggcc atgttgagac atgatgaaac agggtccatt gtgactgggt    780

gaaactgtct tcaatttcct ggtctataaa gcagaggtga gaacaactga ctcatagcat    840

tgcggtgaat attagattaa                                                860


<210>  1885
<211>  65
<212>  PRT
<213>  Homo sapiens

<400>  1885


Met His Met Leu Leu His Leu Val Glu Asn Glu Ala Gln Arg Ser Ser 
1               5                   10                  15      


Val Met Asp Leu Arg Tyr Tyr Gln Gln Lys Ala Glu Glu Leu Gly Phe 
            20                  25                  30          


Gln Leu Arg Met Ser Gly Ser Thr Val Cys Thr Pro Thr His Tyr Ala 
        35                  40                  45              


Thr Leu Pro Leu Thr Met Arg Lys Gln Gly His Phe Phe Phe Ser Gly 
    50                  55                  60                  


Asp 
65  

<210>  1886
<211>  641
<212>  DNA
<213>  Homo sapiens

<400>  1886
gagctggtat acgatgcctc tccagaatca ccttgttctt tctggatcta ttcagaatct     60

gaaactccta gaaaagaaaa atgcaagatg catgagttga gacaggatct cactatgttg    120

ccttgcatgg actggaactc cttggctcaa gaaatcttct tgcctcagcc tcccaaatag    180

ctaggactat atgcacatgc tactacacct agtggaaaat gaagcacaga gaagttcagt    240

gatggacctc agatactacc agcagaaagc agaagagcta ggatttcaac ttaggatgtc    300

tggatccaca gtctgcactc ctacccacta tgctacactg cctctaacta tgaggaagca    360

agggcatttt tttttttctg gtgactaaaa agataagagt tcaagtatgt ggctcctgat    420

aatctaactt atacagcctg gaaaaattga tagttactat atccagactg tctcattcaa    480

ttaacagttt ctcaagtaat cttctagtta ctgtcgtatt ttatctgtat caacttagca    540

aaccaagtcc aaaacatttt atatgtgtct atctttcctg ctgttcatat tattgagtta    600

gccaaataaa ttcaattttt tttctactgt ttgtttctca c                        641


<210>  1887
<211>  65
<212>  PRT
<213>  Homo sapiens

<400>  1887


Met His Met Leu Leu His Leu Val Glu Asn Glu Ala Gln Arg Ser Ser 
1               5                   10                  15      


Val Met Asp Leu Arg Tyr Tyr Gln Gln Lys Ala Glu Glu Leu Gly Phe 
            20                  25                  30          


Gln Leu Arg Met Ser Gly Ser Thr Val Cys Thr Pro Thr His Tyr Ala 
        35                  40                  45              


Thr Leu Pro Leu Thr Met Arg Lys Gln Gly His Phe Phe Phe Ser Gly 
    50                  55                  60                  


Asp 
65  

<210>  1888
<211>  677
<212>  DNA
<213>  Homo sapiens

<400>  1888
atggtagatc caccagcagc ctgtgccctg agcctggaaa agctgcggac actcaactac     60

agctatttca cctctcccca cctaccatgg cttctgtgct gtgattgcac tcctgattca    120

acccctcccc tgatttctgt cggggaaact ttgcattcgg tcgaaattgt tacaaagttc    180

agctggaagt ttccttccct gtgtggtttc ttcccggttc ctctggcagc cctccccaag    240

gacttctgta agacaaagtc ggaagttact tccttgggga ccgagagccc acaggggtct    300

tcctactgct tcttctaccc ctgtatttca ctcagctctc taaatttgtc tcagctccag    360

gaaggcaggg atttcaacct gggcaacaag tccacagaac atgagatttc tgaaggtgtg    420

tgggatacat catggttaca taaaaatcct ttcactatag ttcctgcttc cctatcttca    480

aaatgattcc ctgaagactt ccgccatgac ggtctaaagc ctaacctctg aactgtggat    540

ggaaaattga actccttgat gtgatctctg cacatcatgc aaccctaaac ctaaatatat    600

tctctgtgtg ggagccccat tatttttagt ctaatacatt ttaagtcatc ttaaaaaatt    660

atattttgtt ttctttt                                                   677


<210>  1889
<211>  161
<212>  PRT
<213>  Homo sapiens

<400>  1889


Met Val Asp Pro Pro Ala Ala Cys Ala Leu Ser Leu Glu Lys Leu Arg 
1               5                   10                  15      


Thr Leu Asn Tyr Ser Tyr Phe Thr Ser Pro His Leu Pro Trp Leu Leu 
            20                  25                  30          


Cys Cys Asp Cys Thr Pro Asp Ser Thr Pro Pro Leu Ile Ser Val Gly 
        35                  40                  45              


Glu Thr Leu His Ser Val Glu Ile Val Thr Lys Phe Ser Trp Lys Phe 
    50                  55                  60                  


Pro Ser Leu Cys Gly Phe Phe Pro Val Pro Leu Ala Ala Leu Pro Lys 
65                  70                  75                  80  


Asp Phe Cys Lys Thr Lys Ser Glu Val Thr Ser Leu Gly Thr Glu Ser 
                85                  90                  95      


Pro Gln Gly Ser Ser Tyr Cys Phe Phe Tyr Pro Cys Ile Ser Leu Ser 
            100                 105                 110         


Ser Leu Asn Leu Ser Gln Leu Gln Glu Gly Arg Asp Phe Asn Leu Gly 
        115                 120                 125             


Asn Lys Ser Thr Glu His Glu Ile Ser Glu Gly Val Trp Asp Thr Ser 
    130                 135                 140                 


Trp Leu His Lys Asn Pro Phe Thr Ile Val Pro Ala Ser Leu Ser Ser 
145                 150                 155                 160 


Lys 
    

<210>  1890
<211>  4684
<212>  DNA
<213>  Homo sapiens

<400>  1890
gagagaggga ggacccgtca caggtaacga tgcgcccagt gagcgtcctt tcctctgggg     60

ccaaccagcg tctccgcgcc gctgccgcca acctcgcgcc gaactacgcc ctgagatttg    120

ggcgggtagc gattggggga aaacaggcaa cctaagagtt attaccgtta gcagcgaaga    180

ctgcgactaa cgtcaacgac ggagactgcg tctgccttcg cttccgcctc gtagccccgg    240

gaaccggaaa tccgtctgcc ccgggtcacg tgcttaggag ccatattgtc gctagtggcc    300

gctggggctg ggaggggtgt gctagagagg cgcagcttct ctgggcgtgg tttttatcct    360

gggggaagga tcggtggaat gtgaggggag gtggaggaga tggcggcgac ggcccgggaa    420

gatggcgcca gcggtcaaga gcgaggtcag cggggctgcg agcactatga cagaggatgt    480

ctcctaaagg caccttgctg tgacaagctt tatacttgcc gcttgtgtca tgataacaat    540

gaagatcatc aactagatcg ctttaaagtg aaggaagtgc agtgcataaa ctgtgaaaaa    600

attcaacatg cccaacagac ttgtgaagaa tgtagcacat tgtttggaga atattattgc    660

gatatatgcc atttgtttga caaagataag aagcagtatc actgtgaaaa ctgtggaatt    720

tgtaggattg gtccaaagga agattttttc cattgtttga aatgtaactt atgcctagct    780

atgaatcttc aaggaagaca caagtgtatt gaaaatgtgt cccgacagaa ttgtccaata    840

tgtttggagg acattcacac atcccgtgtt gttgctcatg tcttgccatg tggacatctt    900

ttacatagaa cgtgttatga agaaatgttg aaagaaggct acagatgtcc attatgtatg    960

cactctgctt tagatatgac caggtattgg agacagctgg atgatgaagt agcacagact   1020

cctatgccat cagaatatca gaacatgact gtggatattc tctgcaatga ctgtaatgga   1080

cgatccactg ttcagtttca tatattaggc atgaaatgta agatttgtga atcctataat   1140

actgctcaag ctggaggacg tagaatttca ctggatcagc aatgacgagc ctacacagta   1200

ctggagaact tggcattttc tgatatagaa aaaggctttc cttggtatcg tgttatcatg   1260

tgtcgtcatc tatgcattag agttgatgtg ttttgtacta gtgtcacagc ataaaatcat   1320

attacaagta cgtaaggatt cagggtctct tgatagactt atcatagctc tatattgaat   1380

gaaagccact gtgcttgtgt tttgattgga aattccttta gtgtcagttt tttggaagcc   1440

aatgatgttt gccactgata cattcataga agtgtattat attttcatga agctttgctt   1500

taagtgacac tacgcgtgca gttcatttct agttcttgat agaactgcac ttaattttca   1560

gtagtagtct tgacttttta agggctgtgt tatattaagt tctcccttac tgttaaaacc   1620

taattaaata tgctttagaa ttttctaaga cagtcctctg gatcctctaa atgtgaattt   1680

tgatgtaata actgctaata aaattatatt gaaactgttt tatagaaagt tttttccaaa   1740

gttttctatg tttggctcaa ttagggcagt atcatcagtt ctataatgta aaagaaattt   1800

tctttctttt gaggtattcc ataaaagtag ttgggaaaat tattatgtaa aataataaga   1860

ctcttccaaa gccttaataa aaacatcaac attgaaaaca gtttttttta ggttgcccaa   1920

aattatttct tcaaagagtc attcattcct tcatttagca agtatttatt gagcaactgc   1980

tatgtggcag atatgtttct agatgctgta gagacaacag tgaacaataa agataaaagt   2040

ccttgtcctc acagcagtac attctattgt tcatcatatt tgatcaatgt actcattttt   2100

ctttatgcaa ggagtggatg tcttattgta aatgaataga atatttcttc cctaagcgtg   2160

tgaaaatagg ggatggatga gtgggaaggg catgggatat tcctggcaag atctctgatt   2220

tcataatact tttttgggct catgtagtgg aattaaatat acctcttact tcaggaacaa   2280

agttaacaaa tatgtttgat gatccagccg actttgacac tgttatctcc gtaatagctt   2340

taccattagg ctaggatgta aaatgtacat ttatcagttg ataagtacct attgagcacc   2400

agttgtattt ccaactttga gctatttgaa tcttctttga ataaggaagt tagcctttta   2460

actagaaagc ctaagagttc tggcacattt atttcttctt ttgttgaaat ttattcacct   2520

agataaaggc agcagtttgg gactcagatc tttattttat cccaccttct tgtcttctgt   2580

attccactct tcttatgttc tttcccttca tctgtttcct tggcctggcc agagcagcag   2640

tgctgatctt catttgggaa aggatgttcc tgggtattac caattagtat acagataagt   2700

aaagactagt tttccagatc taatactttt ttttgaagtg gttttgctct gtcatttagg   2760

ctagagtgta gtgaagtgat cgtagctcac tgcagccttg acttcctggg ctgaactgat   2820

ccttccacct cagcctcctg agtagctggg actacaggtg tgtgccacca tgcccagcta   2880

atttttaatt gttttgtaga aacaaagtcc aggctggtct tgaactcctg ggctcaagca   2940

tttctcctac ctcggccttc caagggctag gattacaggc atgagccact gtgcttggtc   3000

cagatgtatt actttttatg tttggtatta ttctgccaaa ccaatcatgt tattgttttt   3060

aatcattgaa tcattggatc tttaaatagg agtgagtata taataataag gctcttctgt   3120

tttcaacatc tgtgctgggt catgcattag cattaattac tacaatgatt ctgtggggta   3180

agtgttgtcc tcatagacaa gaaagctgag gtttagaggt taaaatgaca cattgggggt   3240

aaataacaga cactatatgt tggagttggg aatcagatcc aagtttgact ccaaacccac   3300

ttttaccaca ttgcttttga tctaaacttc tattttgcta aaatacccct cacagctagt   3360

catccatatc attgaagcgc tcatgatttg atagattaac ctttcatttt tttaggtgac   3420

tctagttaga aagtcttatt tcacaatctg attgtttctt taacttagga tccaaacatg   3480

tccaaaataa tgcagagtac atatgcaatc actcgtttat gctgtctagt catgcactta   3540

aagcaatttt caaatgtact caaagtctct aggcttcggt acccagggtt gcttcaagta   3600

tttgttcatg acacgtcaac tcgatgatta aaatccttca acacttctca ttcacaataa   3660

gaataaaatc tacatccctt accattcagt atgcaaaact taaaatacat aactttaccc   3720

ttaaatattt tttctttctc tgacttcata agtataggtt atacctctat aagaaagaag   3780

gtaaaaaact ctcaacaatc ccttctttca gagagaacta ctgttaacat tttaacagac   3840

aacttcattc ttttcctatt cttttttata atgcttacag gaatgttaaa tacttagaca   3900

gatcttaagt acactagaat tatctgtccc tgaaataagt taggttgccc tgccgcagaa   3960

tttgtatcta tagtttattt ggattatttt tgaaaaaagt aaaataacaa tacccttacg   4020

aattttttgg tgcatagcat ctcagcttct tttatcatta aagatgtatg tataaaaaaa   4080

aaatgagtgt atatcaagtt gttcatttct tagtttctgg ggtcttctta accagtacat   4140

agaactcttt atgaattaac tttagcttat gttggaagta gtagtttgtt tatagtgtca   4200

tggattttaa aatcaaactc agtttttatt tcttcactaa aacctatttt catatgatat   4260

acatgttaaa tttccctttt attttggtca tgcatcaaaa taaatttact aagtactaaa   4320

gagccaacat tattttataa gtgcctggca ataggtattc actagttgaa tagtttaatt   4380

tgaaatgaat taattttaaa tgggagttgt tcaaaactat gccacttttt cttttgtcct   4440

ttgtgttatt aaaatttaat tgataattgt gtatattata tatatggagt acaatgtgat   4500

gttttgatat atgtttacag tgtagaatga ttaaatcaat gtaataaatt tattgcctca   4560

taccattttt tgtggtaaaa aaaccactta aaatctactc ttaatatttt tgaaatgtac   4620

aatgcattat ttattatact caccattctg tgtaatagat cagtaaagtt tattcctctt   4680

gtct                                                                4684


<210>  1891
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  1891


Met Ala Ala Thr Ala Arg Glu Asp Gly Ala Ser Gly Gln Glu Arg Gly 
1               5                   10                  15      


Gln Arg Gly Cys Glu His Tyr Asp Arg Gly Cys Leu Leu Lys Ala Pro 
            20                  25                  30          


Cys Cys Asp Lys Leu Tyr Thr Cys Arg Leu Cys His Asp Asn Asn Glu 
        35                  40                  45              


Asp His Gln Leu Asp Arg Phe Lys Val Lys Glu Val Gln Cys Ile Asn 
    50                  55                  60                  


Cys Glu Lys Ile Gln His Ala Gln Gln Thr Cys Glu Glu Cys Ser Thr 
65                  70                  75                  80  


Leu Phe Gly Glu Tyr Tyr Cys Asp Ile Cys His Leu Phe Asp Lys Asp 
                85                  90                  95      


Lys Lys Gln Tyr His Cys Glu Asn Cys Gly Ile Cys Arg Ile Gly Pro 
            100                 105                 110         


Lys Glu Asp Phe Phe His Cys Leu Lys Cys Asn Leu Cys Leu Ala Met 
        115                 120                 125             


Asn Leu Gln Gly Arg His Lys Cys Ile Glu Asn Val Ser Arg Gln Asn 
    130                 135                 140                 


Cys Pro Ile Cys Leu Glu Asp Ile His Thr Ser Arg Val Val Ala His 
145                 150                 155                 160 


Val Leu Pro Cys Gly His Leu Leu His Arg Thr Cys Tyr Glu Glu Met 
                165                 170                 175     


Leu Lys Glu Gly Tyr Arg Cys Pro Leu Cys Met His Ser Ala Leu Asp 
            180                 185                 190         


Met Thr Arg Tyr Trp Arg Gln Leu Asp Asp Glu Val Ala Gln Thr Pro 
        195                 200                 205             


Met Pro Ser Glu Tyr Gln Asn Met Thr Val Asp Ile Leu Cys Asn Asp 
    210                 215                 220                 


Cys Asn Gly Arg Ser Thr Val Gln Phe His Ile Leu Gly Met Lys Cys 
225                 230                 235                 240 


Lys Ile Cys Glu Ser Tyr Asn Thr Ala Gln Ala Gly Gly Arg Arg Ile 
                245                 250                 255     


Ser Leu Asp Gln Gln 
            260     

<210>  1892
<211>  4585
<212>  DNA
<213>  Homo sapiens

<400>  1892
gagagaggga ggacccgtca caggtaacga tgcgcccagt gagcgtcctt tcctctgggg     60

ccaaccagcg tctccgcgcc gctgccgcca acctcgcgcc gaactacgcc ctgagatttg    120

ggcgggtagc gattggggga aaacaggcaa cctaagagtt attaccgtta gcagcgaaga    180

ctgcgactaa cgtcaacgac ggagactgcg tctgccttcg cttccgcctc gtagccccgg    240

gaaccggaaa tccgtctgcc ccgggtcacg tgcttaggag ccatattgtc gctagtggcc    300

gctggggctg ggaggggtgt gctagagagg cgcagcttct ctgggcgtgg tttttatcct    360

gggggaagga tcggtggaat gtgaggggag gtggaggaga tggcggcgac ggcccgggaa    420

gatggcgcca gcggtcaaga gcgaggtcag cggggctgcg agcactatga cagaggatgt    480

ctcctaaagg caccttgctg tgacaagctt tatacttgcc gcttgtgtca tgataacaat    540

gaagatcatc aactagatcg ctttaaagtg aaggaagtgc agtgcataaa ctgtgaaaaa    600

attcaacatg cccaacagac ttgtgaagaa tgtagcacat tgtttggaga atattattgc    660

gatatatgcc atttgtttga caaagataag aagcagtatc actgtgaaaa ctgtggaatt    720

tgtaggattg gtccaaagga agattttttc cattgtttga aatgtaactt atgcctagct    780

atgaatcttc aaggaagaca caagtgtatt gaaaatgtgt cccgacagaa ttgtccaata    840

tgtttggagg acattcacac atcccgtgtt gttgctcatg tcttgccatg tggacatctt    900

ttacatagaa cgtgttatga agaaatgttg aaagaaggct acagatgtcc attatgtatg    960

cactctgctt tagatatgac caggtattgg agacagctgg atgatgaagt agcacagact   1020

cctatgccat cagaatatca gaacatgact gtggatattc tctgcaatga ctgtaatgga   1080

cgatccactg ttcagtttca tatattaggc atgaaatgta agatttgtga atcctataat   1140

actgctcaag ctggaggacg tagaatttca ctggatcagc aatgacgagc ctacacagta   1200

ctggagaact tggcattttc tgatatagaa aaaggctttc cttggtatcg tgttatcatg   1260

tgtcgtcatc tatgcattag agttgatgtg ttttgtacta gtgtcacagc ataaaatcat   1320

attacaagta cgtaaggatt cagggtctct tgatagactt atcatagctc tatattgaat   1380

gaaagccact gtgcttgtgt tttgattgga aattccttta gtgtcagttt tttggaagcc   1440

aatgatgttt gccactgata cattcataga agtgtattat attttcatga agctttgctt   1500

taagtgacac tacgcgtgca gttcatttct agttcttgat agaactgcac ttaattttca   1560

gtagtagtct tgacttttta agggctgtgt tatattaagt tctcccttac tgttaaaacc   1620

taattaaata tgctttagaa ttttctaaga cagtcctctg gatcctctaa atgtgaattt   1680

tgatgtaata actgctaata aaattatatt gaaactgttt tatagaaagt tttttccaaa   1740

gttttctatg tttggctcaa ttagggcagt atcatcagtt ctataatgta aaagaaattt   1800

tctttctttt gaggtattcc ataaaagtag ttgggaaaat tattatgtaa aataataaga   1860

ctcttccaaa gccttaataa aaacatcaac attgaaaaca gtttttttta ggttgcccaa   1920

aattatttct tcaaagagtc attcattcct tcatttagca agtatttatt gagcaactgc   1980

tatgtggcag atatgtttct agatgctgta gagacaacag tgaacaataa agataaaagt   2040

ccttgtcctc acagcagtac attctattgt tcatcatatt tgatcaatgt actcattttt   2100

ctttatgcaa ggagtggatg tcttattgta aatgaataga atatttcttc cctaagcgtg   2160

tgaaaatagg ggatggatga gtgggaaggg catgggatat tcctggcaag atctctgatt   2220

tcataatact tttttgggct catgtagtgg aattaaatat acctcttact tcaggaacaa   2280

agttaacaaa tatgtttgat gatccagccg actttgacac tgttatctcc gtaatagctt   2340

taccattagg ctaggatgta aaatgtacat ttatcagttg ataagtacct attgagcacc   2400

agttgtattt ccaactttga gctatttgaa tcttctttga ataaggaagt tagcctttta   2460

actagaaagc ctaagagttc tggcacattt atttcttctt ttgttgaaat ttattcacct   2520

agataaaggc agcagtttgg gactcagatc tttattttat cccaccttct tgtcttctgt   2580

attccactct tcttatgttc tttcccttca tctgtttcct tggcctggcc agagcagcag   2640

tgctgatctt catttgggaa aggatgttcc tgggtattac caattagtat acagataagt   2700

aaagactagt tttccagatc taatactttt ttttgaagtg gttttgctct gtcatttagg   2760

ctagagtgta gtgaagtgat cgtagctcac tgcagccttg acttcctggg ctgaactgat   2820

ccttccacct cagcctcctg agtagctggg actacaggtg tgtgccacca tgcccagcta   2880

atttttaatt gttttgtaga aacaaagtcc aggctggtct tgaactcctg ggctcaagca   2940

tttctcctac ctcggccttc caagggctag gattacaggc atgagccact gtgcttggtc   3000

cagatgtatt actttttatg tttggtatta ttctgccaaa ccaatcatgt tattgttttt   3060

aatcattgaa tcattggatc tttaaatagg agtgagtata taataataag gctcttctgt   3120

tttcaacatc tgtgctgggt catgcattag cattaattac tacaatgatt ctgtggggta   3180

agtgttgtcc tcatagacaa gaaagctgag gtttagaggt taaaatgaca cattgggggt   3240

aaataacaga cactatatgt tggagttggg aatcagatcc aagtttgact ccaaacccac   3300

ttttaccaca ttgcttttga tctaaacttc tattttgcta aaatacccct cacagctagt   3360

catccatatc attgaagcgc tcatgatttg atagattaac ctttcatttt tttaggtgac   3420

tctagttaga aagtcttatt tcacaatctg attgtttctt taacttagga tccaaacatg   3480

tccaaaataa tgcagagtac atatgcaatc actcgtttat gctgtctagt catgcactta   3540

aagcaatttt caaatgtact caaagtctct aggcttcggt acccagggtt gcttcaagta   3600

tttgttcatg acacgtcaac tcgatgatta aaatccttca acacttctca ttcacaataa   3660

gaataaaatc tacatccctt accattcagt atgcaaaact taaaatacat aactttaccc   3720

ttaaatattt tttctttctc tgacttcata agtataggtt atacctctat aagaaagaag   3780

gtaaaaaact ctcaacaatc ccttctttca gagagaacta ctgttaacat tttaacagac   3840

aacttcattc ttttcctatt cttttttata atgcttacag gaatgttaaa tacttagaca   3900

gatcttaagt acactagaat tatctgtccc tgaaataagt taggttgccc tgccgcagaa   3960

tttgtatcta tagtttattt ggattatttt tgaaaaaagt aaaataacaa tacccttacg   4020

aattttttgg tgcatagcat ctcagcttct tttatcatta aagatgtatg tataaaaaaa   4080

aaatgagtgt atatcaagtt gttcatttct tagtttctgg ggtcttctta accagtacat   4140

agaactcttt atgaattaac tttagcttat gttggaagta gtagtttgtt tatagtgtca   4200

tggattttaa aatcaaactc agtttttatt tcttcactaa aacctatttt catatgatat   4260

acatgttaaa tttccctttt attttggtca tgcatcaaaa taaatttact aagtactaaa   4320

gagccaacat tattttataa gtgcctggca ataggtattc actagttgaa tagtttaatt   4380

tgaaatgaat taattttaaa tgggagttgt tcaaaactat gccacttttt cttttgtcct   4440

ttgtgttatt aaaatttaat tgataattgt gtatattata tatatggagt acaatgtgat   4500

gttttgatat atgtttacag tgtagaatga ttaaatcaat gtaataaatt tattgcctca   4560

taccattttt tgtggtaaaa aaacc                                         4585


<210>  1893
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  1893


Met Ala Ala Thr Ala Arg Glu Asp Gly Ala Ser Gly Gln Glu Arg Gly 
1               5                   10                  15      


Gln Arg Gly Cys Glu His Tyr Asp Arg Gly Cys Leu Leu Lys Ala Pro 
            20                  25                  30          


Cys Cys Asp Lys Leu Tyr Thr Cys Arg Leu Cys His Asp Asn Asn Glu 
        35                  40                  45              


Asp His Gln Leu Asp Arg Phe Lys Val Lys Glu Val Gln Cys Ile Asn 
    50                  55                  60                  


Cys Glu Lys Ile Gln His Ala Gln Gln Thr Cys Glu Glu Cys Ser Thr 
65                  70                  75                  80  


Leu Phe Gly Glu Tyr Tyr Cys Asp Ile Cys His Leu Phe Asp Lys Asp 
                85                  90                  95      


Lys Lys Gln Tyr His Cys Glu Asn Cys Gly Ile Cys Arg Ile Gly Pro 
            100                 105                 110         


Lys Glu Asp Phe Phe His Cys Leu Lys Cys Asn Leu Cys Leu Ala Met 
        115                 120                 125             


Asn Leu Gln Gly Arg His Lys Cys Ile Glu Asn Val Ser Arg Gln Asn 
    130                 135                 140                 


Cys Pro Ile Cys Leu Glu Asp Ile His Thr Ser Arg Val Val Ala His 
145                 150                 155                 160 


Val Leu Pro Cys Gly His Leu Leu His Arg Thr Cys Tyr Glu Glu Met 
                165                 170                 175     


Leu Lys Glu Gly Tyr Arg Cys Pro Leu Cys Met His Ser Ala Leu Asp 
            180                 185                 190         


Met Thr Arg Tyr Trp Arg Gln Leu Asp Asp Glu Val Ala Gln Thr Pro 
        195                 200                 205             


Met Pro Ser Glu Tyr Gln Asn Met Thr Val Asp Ile Leu Cys Asn Asp 
    210                 215                 220                 


Cys Asn Gly Arg Ser Thr Val Gln Phe His Ile Leu Gly Met Lys Cys 
225                 230                 235                 240 


Lys Ile Cys Glu Ser Tyr Asn Thr Ala Gln Ala Gly Gly Arg Arg Ile 
                245                 250                 255     


Ser Leu Asp Gln Gln 
            260     

<210>  1894
<211>  4558
<212>  DNA
<213>  Homo sapiens

<400>  1894
gagagaggga ggacccgtca caggtaacga tgcgcccagt gagcgtcctt tcctctgggg     60

ccaaccagcg tctccgcgcc gctgccgcca acctcgcgcc gaactacgcc ctgagatttg    120

ggcgggtagc gattggggga aaacaggcaa cctaagagtt attaccgtta gcagcgaaga    180

ctgcgactaa cgtcaacgac ggagactgcg tctgccttcg cttccgcctc gtagccccgg    240

gaaccggaaa tccgtctgcc ccgggtcacg tgcttaggag ccatattgtc gctagtggcc    300

gctggggctg ggaggggtgt gctagagagg cgcagcttct ctgggcgtgg tttttatcct    360

gggggaagga tcggtggaat gtgaggggag gtggaggaga tggcggcgac ggcccgggaa    420

gatggcgcca gcggtcaaga gcgaggtcag cggggctgcg agcactatga cagaggatgt    480

ctcctaaagg caccttgctg tgacaagctt tatacttgcc gcttgtgtca tgataacaat    540

gaagatcatc aactagatcg ctttaaagtg aaggaagtgc agtgcataaa ctgtgaaaaa    600

attcaacatg cccaacagac ttgtgaagaa tgtagcacat tgtttggaga atattattgc    660

gatatatgcc atttgtttga caaagataag aagcagtatc actgtgaaaa ctgtggaatt    720

tgtaggattg gtccaaagga agattttttc cattgtttga aatgtaactt atgcctagct    780

atgaatcttc aaggaagaca caagtgtatt gaaaatgtgt cccgacagaa ttgtccaata    840

tgtttggagg acattcacac atcccgtgtt gttgctcatg tcttgccatg tggacatctt    900

ttacatagag gctacagatg tccattatgt atgcactctg ctttagatat gaccaggtat    960

tggagacagc tggatgatga agtagcacag actcctatgc catcagaata tcagaacatg   1020

actgtggata ttctctgcaa tgactgtaat ggacgatcca ctgttcagtt tcatatatta   1080

ggcatgaaat gtaagatttg tgaatcctat aatactgctc aagctggagg acgtagaatt   1140

tcactggatc agcaatgacg agcctacaca gtactggaga acttggcatt ttctgatata   1200

gaaaaaggct ttccttggta tcgtgttatc atgtgtcgtc atctatgcat tagagttgat   1260

gtgttttgta ctagtgtcac agcataaaat catattacaa gtacgtaagg attcagggtc   1320

tcttgataga cttatcatag ctctatattg aatgaaagcc actgtgcttg tgttttgatt   1380

ggaaattcct ttagtgtcag ttttttggaa gccaatgatg tttgccactg atacattcat   1440

agaagtgtat tatattttca tgaagctttg ctttaagtga cactacgcgt gcagttcatt   1500

tctagttctt gatagaactg cacttaattt tcagtagtag tcttgacttt ttaagggctg   1560

tgttatatta agttctccct tactgttaaa acctaattaa atatgcttta gaattttcta   1620

agacagtcct ctggatcctc taaatgtgaa ttttgatgta ataactgcta ataaaattat   1680

attgaaactg ttttatagaa agttttttcc aaagttttct atgtttggct caattagggc   1740

agtatcatca gttctataat gtaaaagaaa ttttctttct tttgaggtat tccataaaag   1800

tagttgggaa aattattatg taaaataata agactcttcc aaagccttaa taaaaacatc   1860

aacattgaaa acagtttttt ttaggttgcc caaaattatt tcttcaaaga gtcattcatt   1920

ccttcattta gcaagtattt attgagcaac tgctatgtgg cagatatgtt tctagatgct   1980

gtagagacaa cagtgaacaa taaagataaa agtccttgtc ctcacagcag tacattctat   2040

tgttcatcat atttgatcaa tgtactcatt tttctttatg caaggagtgg atgtcttatt   2100

gtaaatgaat agaatatttc ttccctaagc gtgtgaaaat aggggatgga tgagtgggaa   2160

gggcatggga tattcctggc aagatctctg atttcataat acttttttgg gctcatgtag   2220

tggaattaaa tatacctctt acttcaggaa caaagttaac aaatatgttt gatgatccag   2280

ccgactttga cactgttatc tccgtaatag ctttaccatt aggctaggat gtaaaatgta   2340

catttatcag ttgataagta cctattgagc accagttgta tttccaactt tgagctattt   2400

gaatcttctt tgaataagga agttagcctt ttaactagaa agcctaagag ttctggcaca   2460

tttatttctt cttttgttga aatttattca cctagataaa ggcagcagtt tgggactcag   2520

atctttattt tatcccacct tcttgtcttc tgtattccac tcttcttatg ttctttccct   2580

tcatctgttt ccttggcctg gccagagcag cagtgctgat cttcatttgg gaaaggatgt   2640

tcctgggtat taccaattag tatacagata agtaaagact agttttccag atctaatact   2700

tttttttgaa gtggttttgc tctgtcattt aggctagagt gtagtgaagt gatcgtagct   2760

cactgcagcc ttgacttcct gggctgaact gatccttcca cctcagcctc ctgagtagct   2820

gggactacag gtgtgtgcca ccatgcccag ctaattttta attgttttgt agaaacaaag   2880

tccaggctgg tcttgaactc ctgggctcaa gcatttctcc tacctcggcc ttccaagggc   2940

taggattaca ggcatgagcc actgtgcttg gtccagatgt attacttttt atgtttggta   3000

ttattctgcc aaaccaatca tgttattgtt tttaatcatt gaatcattgg atctttaaat   3060

aggagtgagt atataataat aaggctcttc tgttttcaac atctgtgctg ggtcatgcat   3120

tagcattaat tactacaatg attctgtggg gtaagtgttg tcctcataga caagaaagct   3180

gaggtttaga ggttaaaatg acacattggg ggtaaataac agacactata tgttggagtt   3240

gggaatcaga tccaagtttg actccaaacc cacttttacc acattgcttt tgatctaaac   3300

ttctattttg ctaaaatacc cctcacagct agtcatccat atcattgaag cgctcatgat   3360

ttgatagatt aacctttcat ttttttaggt gactctagtt agaaagtctt atttcacaat   3420

ctgattgttt ctttaactta ggatccaaac atgtccaaaa taatgcagag tacatatgca   3480

atcactcgtt tatgctgtct agtcatgcac ttaaagcaat tttcaaatgt actcaaagtc   3540

tctaggcttc ggtacccagg gttgcttcaa gtatttgttc atgacacgtc aactcgatga   3600

ttaaaatcct tcaacacttc tcattcacaa taagaataaa atctacatcc cttaccattc   3660

agtatgcaaa acttaaaata cataacttta cccttaaata ttttttcttt ctctgacttc   3720

ataagtatag gttatacctc tataagaaag aaggtaaaaa actctcaaca atcccttctt   3780

tcagagagaa ctactgttaa cattttaaca gacaacttca ttcttttcct attctttttt   3840

ataatgctta caggaatgtt aaatacttag acagatctta agtacactag aattatctgt   3900

ccctgaaata agttaggttg ccctgccgca gaatttgtat ctatagttta tttggattat   3960

ttttgaaaaa agtaaaataa caataccctt acgaattttt tggtgcatag catctcagct   4020

tcttttatca ttaaagatgt atgtataaaa aaaaaatgag tgtatatcaa gttgttcatt   4080

tcttagtttc tggggtcttc ttaaccagta catagaactc tttatgaatt aactttagct   4140

tatgttggaa gtagtagttt gtttatagtg tcatggattt taaaatcaaa ctcagttttt   4200

atttcttcac taaaacctat tttcatatga tatacatgtt aaatttccct tttattttgg   4260

tcatgcatca aaataaattt actaagtact aaagagccaa cattatttta taagtgcctg   4320

gcaataggta ttcactagtt gaatagttta atttgaaatg aattaatttt aaatgggagt   4380

tgttcaaaac tatgccactt tttcttttgt cctttgtgtt attaaaattt aattgataat   4440

tgtgtatatt atatatatgg agtacaatgt gatgttttga tatatgttta cagtgtagaa   4500

tgattaaatc aatgtaataa atttattgcc tcataccatt ttttgtggta aaaaaacc     4558


<210>  1895
<211>  252
<212>  PRT
<213>  Homo sapiens

<400>  1895


Met Ala Ala Thr Ala Arg Glu Asp Gly Ala Ser Gly Gln Glu Arg Gly 
1               5                   10                  15      


Gln Arg Gly Cys Glu His Tyr Asp Arg Gly Cys Leu Leu Lys Ala Pro 
            20                  25                  30          


Cys Cys Asp Lys Leu Tyr Thr Cys Arg Leu Cys His Asp Asn Asn Glu 
        35                  40                  45              


Asp His Gln Leu Asp Arg Phe Lys Val Lys Glu Val Gln Cys Ile Asn 
    50                  55                  60                  


Cys Glu Lys Ile Gln His Ala Gln Gln Thr Cys Glu Glu Cys Ser Thr 
65                  70                  75                  80  


Leu Phe Gly Glu Tyr Tyr Cys Asp Ile Cys His Leu Phe Asp Lys Asp 
                85                  90                  95      


Lys Lys Gln Tyr His Cys Glu Asn Cys Gly Ile Cys Arg Ile Gly Pro 
            100                 105                 110         


Lys Glu Asp Phe Phe His Cys Leu Lys Cys Asn Leu Cys Leu Ala Met 
        115                 120                 125             


Asn Leu Gln Gly Arg His Lys Cys Ile Glu Asn Val Ser Arg Gln Asn 
    130                 135                 140                 


Cys Pro Ile Cys Leu Glu Asp Ile His Thr Ser Arg Val Val Ala His 
145                 150                 155                 160 


Val Leu Pro Cys Gly His Leu Leu His Arg Gly Tyr Arg Cys Pro Leu 
                165                 170                 175     


Cys Met His Ser Ala Leu Asp Met Thr Arg Tyr Trp Arg Gln Leu Asp 
            180                 185                 190         


Asp Glu Val Ala Gln Thr Pro Met Pro Ser Glu Tyr Gln Asn Met Thr 
        195                 200                 205             


Val Asp Ile Leu Cys Asn Asp Cys Asn Gly Arg Ser Thr Val Gln Phe 
    210                 215                 220                 


His Ile Leu Gly Met Lys Cys Lys Ile Cys Glu Ser Tyr Asn Thr Ala 
225                 230                 235                 240 


Gln Ala Gly Gly Arg Arg Ile Ser Leu Asp Gln Gln 
                245                 250         

<210>  1896
<211>  4545
<212>  DNA
<213>  Homo sapiens

<400>  1896
gagagaggga ggacccgtca caggtaacga tgcgcccagt gagcgtcctt tcctctgggg     60

ccaaccagcg tctccgcgcc gctgccgcca acctcgcgcc gaactacgcc ctgagatttg    120

ggcgggtagc gattggggga aaacaggcaa cctaagagtt attaccgtta gcagcgaaga    180

ctgcgactaa cgtcaacgac ggagactgcg tctgccttcg cttccgcctc gtagccccgg    240

gaaccggaaa tccgtctgcc ccgggtcacg tgcttaggag ccatattgtc gctagtggcc    300

gctggggctg ggaggggtgt gctagagagg cgcagcttct ctgggcgtgg tttttatcct    360

gggggaagga tcggtggaat gtgaggggag gtggaggaga tggcggcgac ggcccgggaa    420

gatggcgcca gcggtcaaga gcgaggtcag cggggctgcg agcactatga cagaggatgt    480

ctcctaaagg caccttgctg tgacaagctt tatacttgcc gcttgtgtca tgataacaat    540

gaagatcatc aactagatcg ctttaaagtg aaggaagtgc agtgcataaa ctgtgaaaaa    600

attcaacatg cccaacagac ttgtgaagaa tgtagcacat tgtttggaga atattattgc    660

gatatatgcc atttgtttga caaagataag aagcagtatc actgtgaaaa ctgtggaatt    720

tgtaggattg gtccaaagga agattttttc cattgtttga aatgtaactt atgcctagct    780

atgaatcttc aaggaagaca caagtgtatt gaaaatgtgt cccgacagaa ttgtccaata    840

tgtttggagg acattcacac atcccgtgtt gttgctcatg tcttgccatg tggacatctt    900

ttacatagaa cgtgttatga agaaatgttg aaagaaggct acagatgtcc attatgtatg    960

cactctgctt tagatatgac caggtattgg agacagctgg atgatgaagt agcacagact   1020

cctatgccat cagaatatca gaacatgact gtggatattc tctgcaatga ctgtaatgga   1080

cgatccactg ttcagtttca tatattaggc atgaaatgta agatttgtga atcctataat   1140

actgctcaag ctggaggacg tagaatttca ctggatcagc aatgacgagc ctacacagta   1200

ctggagaact tggcattttc tgatatagaa aaaggctttc cttggtatcg tgttatcatg   1260

tgtcgtcatc tatgcattag agttgatgtg ttttgtacta gtgtcacagc ataaaatcat   1320

attacaagta cgtaaggatt cagggtctct tgatagactt atcatagctc tatattgaat   1380

gaaagccact gtgcttgtgt tttgattgga aattccttta gtgtcagttt tttggaagcc   1440

aatgatgttt gccactgata cattcataga agtgtattat attttcatga agctttgctt   1500

taagtgacac tacgcgtgca gttcatttct agttcttgat agaactgcac ttaattttca   1560

gtagtagtct tgacttttta agggctgtgt tatattaagt tctcccttac tgttaaaacc   1620

taattaaata tgctttagaa ttttctaaga cagtcctctg gatcctctaa atgtgaattt   1680

tgatgtaata actgctaata aaattatatt gaaactgttt tatagaaagt tttttccaaa   1740

gttttctatg tttggctcaa ttagggcagt atcatcagtt ctataatgta aaagaaattt   1800

tctttctttt gaggtattcc ataaaagtag ttgggaaaat tattatgtaa aataataaga   1860

ctcttccaaa gccttaataa aaacatcaac attgaaaaca gtttttttta ggttgcccaa   1920

aattatttct tcaaagagtc attcattcct tcatttagca agtatttatt gagcaactgc   1980

tatgtggcag atatgtttct agatgctgta gagacaacag tgaacaataa agataaaagt   2040

ccttgtcctc acagcagtac attctattgt tcatcatatt tgatcaatgt actcattttt   2100

ctttatgcaa ggagtggatg tcttattgta aatgaataga atatttcttc cctaagcgtg   2160

tgaaaatagg ggatggatga gtgggaaggg catgggatat tcctggcaag atctctgatt   2220

tcataatact tttttgggct catgtagtgg aattaaatat acctcttact tcaggaacaa   2280

agttaacaaa tatgtttgat gatccagccg actttgacac tgttatctcc gtaatagctt   2340

taccattagg ctaggatgta aaatgtacat ttatcagttg ataagtacct attgagcacc   2400

agttgtattt ccaactttga gctatttgaa tcttctttga ataaggaagt tagcctttta   2460

actagaaagc ctaagagttc tggcacattt atttcttctt ttgttgaaat ttattcacct   2520

agataaaggc agcagtttgg gactcagatc tttattttat cccaccttct tgtcttctgt   2580

attccactct tcttatgttc tttcccttca tctgtttcct tggcctggcc agagcagcag   2640

tgctgatctt catttgggaa aggatgttcc tgggtattac caattagtat acagataagt   2700

aaagactagt tttccagatc taatactttt ttttgaagtg gttttgctct gtcatttagg   2760

ctagagtgta gtgaagtgat cgtagctcac tgcagccttg acttcctggg ctgaactgat   2820

ccttccacct cagcctcctg agtagctggg actacaggtg tgtgccacca tgcccagcta   2880

atttttaatt gttttgtaga aacaaagtcc aggctggtct tgaactcctg ggctcaagca   2940

tttctcctac ctcggccttc caagggctag gattacaggc atgagccact gtgcttggtc   3000

cagatgtatt actttttatg tttggtatta ttctgccaaa ccaatcatgt tattgttttt   3060

aatcattgaa tcattggatc tttaaatagg agtgagtata taataataag gctcttctgt   3120

tttcaacatc tgtgctgggt catgcattag cattaattac tacaatgatt ctgtggggta   3180

agtgttgtcc tcatagacaa gaaagctgag gtttagaggt taaaatgaca cattgggggt   3240

aaataacaga cactatatgt tggagttggg aatcagatcc aagtttgact ccaaacccac   3300

ttttaccaca ttgcttttga tctaaacttc tattttgcta aaatacccct cacagctagt   3360

catccatatc attgaagcgc tcatgatttg atagattaac ctttcatttt tttaggtgac   3420

tctagttaga aagtcttatt tcacaatctg attgtttctt taacttagga tccaaacatg   3480

tccaaaataa tgcagagtac atatgcaatc actcgtttat gctgtctagt catgcactta   3540

aagcaatttt caaatgtact caaagtctct aggcttcggt acccagggtt gcttcaagta   3600

tttgttcatg acacgtcaac tcgatgatta aaatccttca acacttctca ttcacaataa   3660

gaataaaatc tacatccctt accattcagt atgcaaaact taaaatacat aactttaccc   3720

ttaaatattt tttctttctc tgacttcata agtataggtt atacctctat aagaaagaag   3780

gtaaaaaact ctcaacaatc ccttctttca gagagaacta ctgttaacat tttaacagac   3840

aacttcattc ttttcctatt cttttttata atgcttacag gaatgttaaa tacttagaca   3900

gatcttaagt acactagaat tatctgtccc tgaaataagt taggttgccc tgccgcagaa   3960

tttgtatcta tagtttattt ggattatttt tgaaaaaagt aaaataacaa tacccttacg   4020

aattttttgg tgcatagcat ctcagcttct tttatcatta aagatgtatg tataaaaaaa   4080

aaatgagtgt atatcaagtt gttcatttct tagtttctgg ggtcttctta accagtacat   4140

agaactcttt atgaattaac tttagcttat gttggaagta gtagtttgtt tatagtgtca   4200

tggattttaa aatcaaactc agtttttatt tcttcactaa aacctatttt catatgatat   4260

acatgttaaa tttccctttt attttggtca tgcatcaaaa taaatttact aagtactaaa   4320

gagccaacat tattttataa gtgcctggca ataggtattc actagttgaa tagtttaatt   4380

tgaaatgaat taattttaaa tgggagttgt tcaaaactat gccacttttt cttttgtcct   4440

ttgtgttatt aaaatttaat tgataattgt gtatattata tatatggagt acaatgtgat   4500

gttttgatat atgtttacag tgtagaatga ttaaatcaat gtaat                   4545


<210>  1897
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  1897


Met Ala Ala Thr Ala Arg Glu Asp Gly Ala Ser Gly Gln Glu Arg Gly 
1               5                   10                  15      


Gln Arg Gly Cys Glu His Tyr Asp Arg Gly Cys Leu Leu Lys Ala Pro 
            20                  25                  30          


Cys Cys Asp Lys Leu Tyr Thr Cys Arg Leu Cys His Asp Asn Asn Glu 
        35                  40                  45              


Asp His Gln Leu Asp Arg Phe Lys Val Lys Glu Val Gln Cys Ile Asn 
    50                  55                  60                  


Cys Glu Lys Ile Gln His Ala Gln Gln Thr Cys Glu Glu Cys Ser Thr 
65                  70                  75                  80  


Leu Phe Gly Glu Tyr Tyr Cys Asp Ile Cys His Leu Phe Asp Lys Asp 
                85                  90                  95      


Lys Lys Gln Tyr His Cys Glu Asn Cys Gly Ile Cys Arg Ile Gly Pro 
            100                 105                 110         


Lys Glu Asp Phe Phe His Cys Leu Lys Cys Asn Leu Cys Leu Ala Met 
        115                 120                 125             


Asn Leu Gln Gly Arg His Lys Cys Ile Glu Asn Val Ser Arg Gln Asn 
    130                 135                 140                 


Cys Pro Ile Cys Leu Glu Asp Ile His Thr Ser Arg Val Val Ala His 
145                 150                 155                 160 


Val Leu Pro Cys Gly His Leu Leu His Arg Thr Cys Tyr Glu Glu Met 
                165                 170                 175     


Leu Lys Glu Gly Tyr Arg Cys Pro Leu Cys Met His Ser Ala Leu Asp 
            180                 185                 190         


Met Thr Arg Tyr Trp Arg Gln Leu Asp Asp Glu Val Ala Gln Thr Pro 
        195                 200                 205             


Met Pro Ser Glu Tyr Gln Asn Met Thr Val Asp Ile Leu Cys Asn Asp 
    210                 215                 220                 


Cys Asn Gly Arg Ser Thr Val Gln Phe His Ile Leu Gly Met Lys Cys 
225                 230                 235                 240 


Lys Ile Cys Glu Ser Tyr Asn Thr Ala Gln Ala Gly Gly Arg Arg Ile 
                245                 250                 255     


Ser Leu Asp Gln Gln 
            260     

<210>  1898
<211>  2996
<212>  DNA
<213>  Homo sapiens

<400>  1898
ggtcaagagc gaggtcagcg gggctgcgag cactatgaca gaggatgtct cctaaaggtg     60

acgccttcta tggactcttc cctgacaagc ttccgtcagg caccttgctg tgacaagctt    120

tatacttgcc gcttgtgtca tgataacaat gaagatcatc aactagatcg ctttaaagtg    180

aaggaagtgc agtgcataaa ctgtgaaaaa attcaacatg cccaacagac ttgtgaagaa    240

tgtagcacat tgtttggaga atattattgc gatatatgcc atttgtttga caaagataag    300

aagcagtatc actgtgaaaa ctgtggaatt tgtaggattg gtccaaagga agattttttc    360

cattgtttga aatgtaactt atgcctagct atgaatcttc aaggaagaca caagtgtatt    420

gaaaatgtgt cccgacagaa ttgtccaata tgtttggagg acattcacac atcccgtgtt    480

gttgctcatg tcttgccatg tggacatctt ttacatagaa cgtgttatga agaaatgttg    540

aaagaaggct acagatgtcc attatgtatg cactctgctt tagatatgac caggtattgg    600

agacagctgg atgatgaagt agcacagact cctatgccat cagaatatca gaacatgact    660

gtggatattc tctgcaatga ctgtaatgga cgatccactg ttcagtttca tatattaggc    720

atgaaatgta agatttgtga atcctataat actgctcaag ctggaggacg tagaatttca    780

ctggatcagc aatgacgagc ctacacagta ctggagaact tggcattttc tgatatagaa    840

aaaggctttc cttggtatcg tgttatcatg tgtcgtcatc tatgcattag agttgatgtg    900

ttttgtacta gtgtcacagc ataaaatcat attacaagta cgtaaggatt cagggtctct    960

tgatagactt atcatagctc tatattgaat gaaagccact gtgcttgtgt tttgattgga   1020

aattccttta gtgtcagttt tttggaagcc aatgatgttt gccactgata cattcataga   1080

agtgtattat attttcatga agctttgctt taagtgacac tacgcgtgca gttcatttct   1140

agttcttgat agaactgcac ttaattttca gtagtagtct tgacttttta agggctgtgt   1200

tatattaagt tctcccttac tgttaaaacc taattaaata tgctttagaa ttttctaaga   1260

cagtcctctg gatcctctaa atgtgaattt tgatgtaata actgctaata aaattatatt   1320

gaaactgttt tatagaaagt tttttccaaa gttttctatg tttggctcaa ttagggcagt   1380

atcatcagtt ctataatgta aaagaaattt tctttctttt gaggtattcc ataaaagtag   1440

ttgggaaaat tattatgtaa aataataaga ctcttccaaa gccttaataa aaacatcaac   1500

attgaaaaca gtttttttta ggttgcccaa aattatttct tcaaagagtc attcattcct   1560

tcatttagca agtatttatt gagcaactgc tatgtggcag atatgtttct agatgctgta   1620

gagacaacag tgaacaataa agataaaagt ccttgtcctc acagcagtac attctattgt   1680

tcatcatatt tgatcaatgt actcattttt ctttatgcaa ggagtggatg tcttattgta   1740

aatgaataga atatttcttc cctaagcgtg tgaaaatagg ggatggatga gtgggaaggg   1800

catgggatat tcctggcaag atctctgatt tcataatact tttttgggct catgtagtgg   1860

aattaaatat acctcttact tcaggaacaa agttaacaaa tatgtttgat gatccagccg   1920

actttgacac tgttatctcc gtaatagctt taccattagg ctaggatgta aaatgtacat   1980

ttatcagttg ataagtacct attgagcacc agttgtattt ccaactttga gctatttgaa   2040

tcttctttga ataaggaagt tagcctttta actagaaagc ctaagagttc tggcacattt   2100

atttcttctt ttgttgaaat ttattcacct agataaaggc agcagtttgg gactcagatc   2160

tttattttat cccaccttct tgtcttctgt attccactct tcttatgttc tttcccttca   2220

tctgtttcct tggcctggcc agagcagcag tgctgatctt catttgggaa aggatgttcc   2280

tgggtattac caattagtat acagataagt aaagactagt tttccagatc taatactttt   2340

ttttgaagtg gttttgctct gtcatttagg ctagagtgta gtgaagtgat cgtagctcac   2400

tgcagccttg acttcctggg ctgaactgat ccttccacct cagcctcctg agtagctggg   2460

actacaggtg tgtgccacca tgcccagcta atttttaatt gttttgtaga aacaaagtcc   2520

aggctggtct tgaactcctg ggctcaagca tttctcctac ctcggccttc caagggctag   2580

gattacaggc atgagccact gtgcttggtc cagatgtatt actttttatg tttggtatta   2640

ttctgccaaa ccaatcatgt tattgttttt aatcattgaa tcattggatc tttaaatagg   2700

agtgagtata taataataag gctcttctgt tttcaacatc tgtgctgggt catgcattag   2760

cattaattac tacaatgatt ctgtggggta agtgttgtcc tcatagacaa gaaagctgag   2820

gtttagaggt taaaatgaca cattgggggt aaataacaga cactatatgt tggagttggg   2880

aatcagatcc aagtttgact ccaaacccac ttttaccaca ttgcttttga tctaaacttc   2940

tattttgcta aaatacccct cacagctagt catccatatc attgaagcgc tcatga       2996


<210>  1899
<211>  241
<212>  PRT
<213>  Homo sapiens

<400>  1899


Met Asp Ser Ser Leu Thr Ser Phe Arg Gln Ala Pro Cys Cys Asp Lys 
1               5                   10                  15      


Leu Tyr Thr Cys Arg Leu Cys His Asp Asn Asn Glu Asp His Gln Leu 
            20                  25                  30          


Asp Arg Phe Lys Val Lys Glu Val Gln Cys Ile Asn Cys Glu Lys Ile 
        35                  40                  45              


Gln His Ala Gln Gln Thr Cys Glu Glu Cys Ser Thr Leu Phe Gly Glu 
    50                  55                  60                  


Tyr Tyr Cys Asp Ile Cys His Leu Phe Asp Lys Asp Lys Lys Gln Tyr 
65                  70                  75                  80  


His Cys Glu Asn Cys Gly Ile Cys Arg Ile Gly Pro Lys Glu Asp Phe 
                85                  90                  95      


Phe His Cys Leu Lys Cys Asn Leu Cys Leu Ala Met Asn Leu Gln Gly 
            100                 105                 110         


Arg His Lys Cys Ile Glu Asn Val Ser Arg Gln Asn Cys Pro Ile Cys 
        115                 120                 125             


Leu Glu Asp Ile His Thr Ser Arg Val Val Ala His Val Leu Pro Cys 
    130                 135                 140                 


Gly His Leu Leu His Arg Thr Cys Tyr Glu Glu Met Leu Lys Glu Gly 
145                 150                 155                 160 


Tyr Arg Cys Pro Leu Cys Met His Ser Ala Leu Asp Met Thr Arg Tyr 
                165                 170                 175     


Trp Arg Gln Leu Asp Asp Glu Val Ala Gln Thr Pro Met Pro Ser Glu 
            180                 185                 190         


Tyr Gln Asn Met Thr Val Asp Ile Leu Cys Asn Asp Cys Asn Gly Arg 
        195                 200                 205             


Ser Thr Val Gln Phe His Ile Leu Gly Met Lys Cys Lys Ile Cys Glu 
    210                 215                 220                 


Ser Tyr Asn Thr Ala Gln Ala Gly Gly Arg Arg Ile Ser Leu Asp Gln 
225                 230                 235                 240 


Gln 
    

<210>  1900
<211>  2851
<212>  DNA
<213>  Homo sapiens

<400>  1900
aggtggagga gatggcggcg acggcccggg aagatggcgc cagcggtcaa gagcgaggtc     60

agcggggctg cgagcactat gacagaggat gtctcctaaa ggcccaacag acttgtgaag    120

aatgtagcac attgtttgga gaatattatt gcgatatatg ccatttgttt gacaaagata    180

agaagcagta tcactgtgaa aactgtggaa tttgtaggat tggtccaaag gaagattttt    240

tccattgttt gaaatgtaac ttatgcctag ctatgaatct tcaaggaaga cacaagtgta    300

ttgaaaatgt gtcccgacag aattgtccaa tatgtttgga ggacattcac acatcccgtg    360

ttgttgctca tgtcttgcca tgtggacatc ttttacatag aggctacaga tgtccattat    420

gtatgcactc tgctttagat atgaccaggt attggagaca gctggatgat gaagtagcac    480

agactcctat gccatcagaa tatcagaaca tgactgtgga tattctctgc aatgactgta    540

atggacgatc cactgttcag tttcatatat taggcatgaa atgtaagatt tgtgaatcct    600

ataatactgc tcaagctgga ggacgtagaa tttcactgga tcagcaatga cgagcctaca    660

cagtactgga gaacttggca ttttctgata tagaaaaagg ctttccttgg tatcgtgtta    720

tcatgtgtcg tcatctatgc attagagttg atgtgttttg tactagtgtc acagcataaa    780

atcatattac aagtacgtaa ggattcaggg tctcttgata gacttatcat agctctatat    840

tgaatgaaag ccactgtgct tgtgttttga ttggaaattc ctttagtgtc agttttttgg    900

aagccaatga tgtttgccac tgatacattc atagaagtgt attatatttt catgaagctt    960

tgctttaagt gacactacgc gtgcagttca tttctagttc ttgatagaac tgcacttaat   1020

tttcagtagt agtcttgact ttttaagggc tgtgttatat taagttctcc cttactgtta   1080

aaacctaatt aaatatgctt tagaattttc taagacagtc ctctggatcc tctaaatgtg   1140

aattttgatg taataactgc taataaaatt atattgaaac tgttttatag aaagtttttt   1200

ccaaagtttt ctatgtttgg ctcaattagg gcagtatcat cagttctata atgtaaaaga   1260

aattttcttt cttttgaggt attccataaa agtagttggg aaaattatta tgtaaaataa   1320

taagactctt ccaaagcctt aataaaaaca tcaacattga aaacagtttt ttttaggttg   1380

cccaaaatta tttcttcaaa gagtcattca ttccttcatt tagcaagtat ttattgagca   1440

actgctatgt ggcagatatg tttctagatg ctgtagagac aacagtgaac aataaagata   1500

aaagtccttg tcctcacagc agtacattct attgttcatc atatttgatc aatgtactca   1560

tttttcttta tgcaaggagt ggatgtctta ttgtaaatga atagaatatt tcttccctaa   1620

gcgtgtgaaa ataggggatg gatgagtggg aagggcatgg gatattcctg gcaagatctc   1680

tgatttcata atactttttt gggctcatgt agtggaatta aatatacctc ttacttcagg   1740

aacaaagtta acaaatatgt ttgatgatcc agccgacttt gacactgtta tctccgtaat   1800

agctttacca ttaggctagg atgtaaaatg tacatttatc agttgataag tacctattga   1860

gcaccagttg tatttccaac tttgagctat ttgaatcttc tttgaataag gaagttagcc   1920

ttttaactag aaagcctaag agttctggca catttatttc ttcttttgtt gaaatttatt   1980

cacctagata aaggcagcag tttgggactc agatctttat tttatcccac cttcttgtct   2040

tctgtattcc actcttctta tgttctttcc cttcatctgt ttccttggcc tggccagagc   2100

agcagtgctg atcttcattt gggaaaggat gttcctgggt attaccaatt agtatacaga   2160

taagtaaaga ctagttttcc agatctaata cttttttttg aagtggtttt gctctgtcat   2220

ttaggctaga gtgtagtgaa gtgatcgtag ctcactgcag ccttgacttc ctgggctgaa   2280

ctgatccttc cacctcagcc tcctgagtag ctgggactac aggtgtgtgc caccatgccc   2340

agctaatttt taattgtttt gtagaaacaa agtccaggct ggtcttgaac tcctgggctc   2400

aagcatttct cctacctcgg ccttccaagg gctaggatta caggcatgag ccactgtgct   2460

tggtccagat gtattacttt ttatgtttgg tattattctg ccaaaccaat catgttattg   2520

tttttaatca ttgaatcatt ggatctttaa ataggagtga gtatataata ataaggctct   2580

tctgttttca acatctgtgc tgggtcatgc attagcatta attactacaa tgattctgtg   2640

gggtaagtgt tgtcctcata gacaagaaag ctgaggttta gaggttaaaa tgacacattg   2700

ggggtaaata acagacacta tatgttggag ttgggaatca gatccaagtt tgactccaaa   2760

cccactttta ccacattgct tttgatctaa acttctattt tgctaaaata cccctcacag   2820

ctagtcatcc atatcattga agcgctcatg a                                  2851


<210>  1901
<211>  212
<212>  PRT
<213>  Homo sapiens

<400>  1901


Met Ala Ala Thr Ala Arg Glu Asp Gly Ala Ser Gly Gln Glu Arg Gly 
1               5                   10                  15      


Gln Arg Gly Cys Glu His Tyr Asp Arg Gly Cys Leu Leu Lys Ala Gln 
            20                  25                  30          


Gln Thr Cys Glu Glu Cys Ser Thr Leu Phe Gly Glu Tyr Tyr Cys Asp 
        35                  40                  45              


Ile Cys His Leu Phe Asp Lys Asp Lys Lys Gln Tyr His Cys Glu Asn 
    50                  55                  60                  


Cys Gly Ile Cys Arg Ile Gly Pro Lys Glu Asp Phe Phe His Cys Leu 
65                  70                  75                  80  


Lys Cys Asn Leu Cys Leu Ala Met Asn Leu Gln Gly Arg His Lys Cys 
                85                  90                  95      


Ile Glu Asn Val Ser Arg Gln Asn Cys Pro Ile Cys Leu Glu Asp Ile 
            100                 105                 110         


His Thr Ser Arg Val Val Ala His Val Leu Pro Cys Gly His Leu Leu 
        115                 120                 125             


His Arg Gly Tyr Arg Cys Pro Leu Cys Met His Ser Ala Leu Asp Met 
    130                 135                 140                 


Thr Arg Tyr Trp Arg Gln Leu Asp Asp Glu Val Ala Gln Thr Pro Met 
145                 150                 155                 160 


Pro Ser Glu Tyr Gln Asn Met Thr Val Asp Ile Leu Cys Asn Asp Cys 
                165                 170                 175     


Asn Gly Arg Ser Thr Val Gln Phe His Ile Leu Gly Met Lys Cys Lys 
            180                 185                 190         


Ile Cys Glu Ser Tyr Asn Thr Ala Gln Ala Gly Gly Arg Arg Ile Ser 
        195                 200                 205             


Leu Asp Gln Gln 
    210         

<210>  1902
<211>  3087
<212>  DNA
<213>  Homo sapiens

<400>  1902
ctgccccggg tcacgtgctt aggagccata ttgtcgctag tggccgctgg ggctgggagg     60

ggtgtgctag agaggcgcag cttctctggg cgtggttttt atcctggggg aaggatcggt    120

ggaatgtgag gggaggtgga ggagatggcg gcgacggccc gggaagatgg cgccagcggt    180

caagagcgag gcaccttgct gtgacaagct ttatacttgc cgcttgtgtc atgataacaa    240

tgaagatcat caactagatc gctttaaagt gaaggaagtg cagtgcataa actgtgaaaa    300

aattcaacat gcccaacaga cttgtgaaga atgtagcaca ttgtttggag aatattattg    360

cgatatatgc catttgtttg acaaagataa gaagcagtat cactgtgaaa actgtggaat    420

ttgtaggatt ggtccaaagg aagatttttt ccattgtttg aaatgtaact tatgcctagc    480

tatgaatctt caaggaagac acaagtgtat tgaaaatgtg tcccgacaga attgtccaat    540

atgtttggag gacattcaca catcccgtgt tgttgctcat gtcttgccat gtggacatct    600

tttacataga acgtgttatg aagaaatgtt gaaagaaggc tacagatgtc cattatgtat    660

gcactctgct ttagatatga ccaggtattg gagacagctg gatgatgaag tagcacagac    720

tcctatgcca tcagaatatc agaacatgac tgtggatatt ctctgcaatg actgtaatgg    780

acgatccact gttcagtttc atatattagg catgaaatgt aagatttgtg aatcctataa    840

tactgctcaa gctggaggac gtagaatttc actggatcag caatgacgag cctacacagt    900

actggagaac ttggcatttt ctgatataga aaaaggcttt ccttggtatc gtgttatcat    960

gtgtcgtcat ctatgcatta gagttgatgt gttttgtact agtgtcacag cataaaatca   1020

tattacaagt acgtaaggat tcagggtctc ttgatagact tatcatagct ctatattgaa   1080

tgaaagccac tgtgcttgtg ttttgattgg aaattccttt agtgtcagtt ttttggaagc   1140

caatgatgtt tgccactgat acattcatag aagtgtatta tattttcatg aagctttgct   1200

ttaagtgaca ctacgcgtgc agttcatttc tagttcttga tagaactgca cttaattttc   1260

agtagtagtc ttgacttttt aagggctgtg ttatattaag ttctccctta ctgttaaaac   1320

ctaattaaat atgctttaga attttctaag acagtcctct ggatcctcta aatgtgaatt   1380

ttgatgtaat aactgctaat aaaattatat tgaaactgtt ttatagaaag ttttttccaa   1440

agttttctat gtttggctca attagggcag tatcatcagt tctataatgt aaaagaaatt   1500

ttctttcttt tgaggtattc cataaaagta gttgggaaaa ttattatgta aaataataag   1560

actcttccaa agccttaata aaaacatcaa cattgaaaac agtttttttt aggttgccca   1620

aaattatttc ttcaaagagt cattcattcc ttcatttagc aagtatttat tgagcaactg   1680

ctatgtggca gatatgtttc tagatgctgt agagacaaca gtgaacaata aagataaaag   1740

tccttgtcct cacagcagta cattctattg ttcatcatat ttgatcaatg tactcatttt   1800

tctttatgca aggagtggat gtcttattgt aaatgaatag aatatttctt ccctaagcgt   1860

gtgaaaatag gggatggatg agtgggaagg gcatgggata ttcctggcaa gatctctgat   1920

ttcataatac ttttttgggc tcatgtagtg gaattaaata tacctcttac ttcaggaaca   1980

aagttaacaa atatgtttga tgatccagcc gactttgaca ctgttatctc cgtaatagct   2040

ttaccattag gctaggatgt aaaatgtaca tttatcagtt gataagtacc tattgagcac   2100

cagttgtatt tccaactttg agctatttga atcttctttg aataaggaag ttagcctttt   2160

aactagaaag cctaagagtt ctggcacatt tatttcttct tttgttgaaa tttattcacc   2220

tagataaagg cagcagtttg ggactcagat ctttatttta tcccaccttc ttgtcttctg   2280

tattccactc ttcttatgtt ctttcccttc atctgtttcc ttggcctggc cagagcagca   2340

gtgctgatct tcatttggga aaggatgttc ctgggtatta ccaattagta tacagataag   2400

taaagactag ttttccagat ctaatacttt tttttgaagt ggttttgctc tgtcatttag   2460

gctagagtgt agtgaagtga tcgtagctca ctgcagcctt gacttcctgg gctgaactga   2520

tccttccacc tcagcctcct gagtagctgg gactacaggt gtgtgccacc atgcccagct   2580

aatttttaat tgttttgtag aaacaaagtc caggctggtc ttgaactcct gggctcaagc   2640

atttctccta cctcggcctt ccaagggcta ggattacagg catgagccac tgtgcttggt   2700

ccagatgtat tactttttat gtttggtatt attctgccaa accaatcatg ttattgtttt   2760

taatcattga atcattggat ctttaaatag gagtgagtat ataataataa ggctcttctg   2820

ttttcaacat ctgtgctggg tcatgcatta gcattaatta ctacaatgat tctgtggggt   2880

aagtgttgtc ctcatagaca agaaagctga ggtttagagg ttaaaatgac acattggggg   2940

taaataacag acactatatg ttggagttgg gaatcagatc caagtttgac tccaaaccca   3000

cttttaccac attgcttttg atctaaactt ctattttgct aaaatacccc tcacagctag   3060

tcatccatat cattgaagcg ctcatga                                       3087


<210>  1903
<211>  239
<212>  PRT
<213>  Homo sapiens

<400>  1903


Met Ala Pro Ala Val Lys Ser Glu Ala Pro Cys Cys Asp Lys Leu Tyr 
1               5                   10                  15      


Thr Cys Arg Leu Cys His Asp Asn Asn Glu Asp His Gln Leu Asp Arg 
            20                  25                  30          


Phe Lys Val Lys Glu Val Gln Cys Ile Asn Cys Glu Lys Ile Gln His 
        35                  40                  45              


Ala Gln Gln Thr Cys Glu Glu Cys Ser Thr Leu Phe Gly Glu Tyr Tyr 
    50                  55                  60                  


Cys Asp Ile Cys His Leu Phe Asp Lys Asp Lys Lys Gln Tyr His Cys 
65                  70                  75                  80  


Glu Asn Cys Gly Ile Cys Arg Ile Gly Pro Lys Glu Asp Phe Phe His 
                85                  90                  95      


Cys Leu Lys Cys Asn Leu Cys Leu Ala Met Asn Leu Gln Gly Arg His 
            100                 105                 110         


Lys Cys Ile Glu Asn Val Ser Arg Gln Asn Cys Pro Ile Cys Leu Glu 
        115                 120                 125             


Asp Ile His Thr Ser Arg Val Val Ala His Val Leu Pro Cys Gly His 
    130                 135                 140                 


Leu Leu His Arg Thr Cys Tyr Glu Glu Met Leu Lys Glu Gly Tyr Arg 
145                 150                 155                 160 


Cys Pro Leu Cys Met His Ser Ala Leu Asp Met Thr Arg Tyr Trp Arg 
                165                 170                 175     


Gln Leu Asp Asp Glu Val Ala Gln Thr Pro Met Pro Ser Glu Tyr Gln 
            180                 185                 190         


Asn Met Thr Val Asp Ile Leu Cys Asn Asp Cys Asn Gly Arg Ser Thr 
        195                 200                 205             


Val Gln Phe His Ile Leu Gly Met Lys Cys Lys Ile Cys Glu Ser Tyr 
    210                 215                 220                 


Asn Thr Ala Gln Ala Gly Gly Arg Arg Ile Ser Leu Asp Gln Gln 
225                 230                 235                 

<210>  1904
<211>  4381
<212>  DNA
<213>  Homo sapiens

<400>  1904
gagagaggga ggacccgtca caggtaacga tgcgcccagt gagcgtcctt tcctctgggg     60

ccaaccagcg tctccgcgcc gctgccgcca acctcgcgcc gaactacgcc ctgagatttg    120

ggcgggtagc gattggggga aaacaggcaa cctaagagtt attaccgtta gcagcgaaga    180

ctgcgactaa cgtcaacgac ggagactgcg tctgccttcg cttccgcctc gtagccccgg    240

gaaccggaaa tccgtctgcc ccgggtcacg tgcttaggag ccatattgtc gctagtggcc    300

gctggggctg ggaggggtgt gctagagagg cgcagcttct ctgggcgtgg tttttatcct    360

gggggaagga tcggtggaat gtgaggggag gtggaggaga tggcggcgac ggcccgggaa    420

gatggcgcca gcggtcaaga gcgaggtcag cggggctgcg agcactatga cagaggatgt    480

ctcctaaagg caccttgctg tgacaagctt tatacttgcc gcttgtgtca tgataacaat    540

gaagatcatc aactagatcg ctttaaagtg aaggaagtgc agtgcataaa ctgtgaaaaa    600

attcaacatg cccaacagac ttgtgaagaa tgtagcacat tgtttggaga atattattgc    660

gatatatgcc atttgtttga caaagataag aagcagtatc actgtgaaaa ctgtggaatt    720

tgtaggattg gtccaaagga agattttttc cattgtttga aatgtaactt atgcctagct    780

atgaatcttc aaggaagaca caagtgtatt gaaaatgtgt cccgacagaa ttgtccaata    840

tgtttggagg acattcacac atcccgtgtt gttgctcatg tcttgccatg tggacatctt    900

ttacataggt aaagtaacat ctttttctca atgatgtttg aaaatagtgg agacagtttt    960

tgttttacta aaataatctt atattttctt tcagaacgtg ttatgaagaa atgttgaaag   1020

agtgagtgtt tgggatttta aaaataattg taagatgttt gacttttttg tgtgtgtggt   1080

gtggggaggt ggacaaacat tgttacttat actatattgg gcatggcaat atttatattg   1140

aaatgggtag ggtagatgaa tattgttaaa acaggacaaa gtgtcttgga tatagaacta   1200

cacttttgcc atatgtttct cttaaatctt gtctcctccc acaatttgag gtagttacct   1260

cttttttttc tggccatata taccaggaag tgcagttttt gccagatgca gttatagtgt   1320

tgtaaaaatg ctgaaaaata ttgccaaaaa tttgttaggt tgttatattg gccaagtata   1380

gtaaactaaa agaaagtagg tgaagtgatc attaaagcta agactttatt aatggaaaag   1440

atattaaaat tagatgaaaa taattgaaaa gagaagactg tattttggtc ctacatattg   1500

atgagcaaaa atgtgaagag ctagagagag cattcttttt ttcaaatttt tagaaaggaa   1560

ataatatctg aataatttta aacaaataca gtctctttac atgagtgtat taagaaatta   1620

aggttgttta gataaggagt agcttaatta gtttataaaa atatatgaag tgtattctac   1680

aaagaatatg gactaattcc tctccatttt agagtactga ggaaaaagac ttagttttaa   1740

ataagtatac aggaattaat ttaaaagttt tatagtgtga aagttcccag gttcctaaga   1800

gattatcttg aaatggagga aaatgcctgt tttgaatggt tcatgtggca gttagcctgc   1860

atcttcttgt atacctgaat taatatattc ttgtttaata tttggaaaat aacctttcta   1920

tctctttcag aggctacaga tgtccattat gtatgcactc tgctttagat atgaccaggt   1980

attggagaca gctggatgat gaagtagcac agactcctat gccatcagaa tatcagaaca   2040

tgactgtgga tattctctgc aatgactgta atggacgatc cactgttcag tttcatatat   2100

taggcatgaa atgtaagatt tgtgaatcct ataatactgc tcaagctgga ggacgtagaa   2160

tttcactgga tcagcaatga cgagcctaca cagtactgga gaacttggca ttttctgata   2220

tagaaaaagg ctttccttgg tatcgtgtta tcatgtgtcg tcatctatgc attagagttg   2280

atgtgttttg tactagtgtc acagcataaa atcatattac aagtacgtaa ggattcaggg   2340

tctcttgata gacttatcat agctctatat tgaatgaaag ccactgtgct tgtgttttga   2400

ttggaaattc ctttagtgtc agttttttgg aagccaatga tgtttgccac tgatacattc   2460

atagaagtgt attatatttt catgaagctt tgctttaagt gacactacgc gtgcagttca   2520

tttctagttc ttgatagaac tgcacttaat tttcagtagt agtcttgact ttttaagggc   2580

tgtgttatat taagttctcc cttactgtta aaacctaatt aaatatgctt tagaattttc   2640

taagacagtc ctctggatcc tctaaatgtg aattttgatg taataactgc taataaaatt   2700

atattgaaac tgttttatag aaagtttttt ccaaagtttt ctatgtttgg ctcaattagg   2760

gcagtatcat cagttctata atgtaaaaga aattttcttt cttttgaggt attccataaa   2820

agtagttggg aaaattatta tgtaaaataa taagactctt ccaaagcctt aataaaaaca   2880

tcaacattga aaacagtttt ttttaggttg cccaaaatta tttcttcaaa gagtcattca   2940

ttccttcatt tagcaagtat ttattgagca actgctatgt ggcagatatg tttctagatg   3000

ctgtagagac aacagtgaac aataaagata aaagtccttg tcctcacagc agtacattct   3060

attgttcatc atatttgatc aatgtactca tttttcttta tgcaaggagt ggatgtctta   3120

ttgtaaatga atagaatatt tcttccctaa gcgtgtgaaa ataggggatg gatgagtggg   3180

aagggcatgg gatattcctg gcaagatctc tgatttcata atactttttt gggctcatgt   3240

agtggaatta aatatacctc ttacttcagg aacaaagtta acaaatatgt ttgatgatcc   3300

agccgacttt gacactgtta tctccgtaat agctttacca ttaggctagg atgtaaaatg   3360

tacatttatc agttgataag tacctattga gcaccagttg tatttccaac tttgagctat   3420

ttgaatcttc tttgaataag gaagttagcc ttttaactag aaagcctaag agttctggca   3480

catttatttc ttcttttgtt gaaatttatt cacctagata aaggcagcag tttgggactc   3540

agatctttat tttatcccac cttcttgtct tctgtattcc actcttctta tgttctttcc   3600

cttcatctgt ttccttggcc tggccagagc agcagtgctg atcttcattt gggaaaggat   3660

gttcctgggt attaccaatt agtatacaga taagtaaaga ctagttttcc agatctaata   3720

cttttttttg aagtggtttt gctctgtcat ttaggctaga gtgtagtgaa gtgatcgtag   3780

ctcactgcag ccttgacttc ctgggctgaa ctgatccttc cacctcagcc tcctgagtag   3840

ctgggactac aggtgtgtgc caccatgccc agctaatttt taattgtttt gtagaaacaa   3900

agtccaggct ggtcttgaac tcctgggctc aagcatttct cctacctcgg ccttccaagg   3960

gctaggatta caggcatgag ccactgtgct tggtccagat gtattacttt ttatgtttgg   4020

tattattctg ccaaaccaat catgttattg tttttaatca ttgaatcatt ggatctttaa   4080

ataggagtga gtatataata ataaggctct tctgttttca acatctgtgc tgggtcatgc   4140

attagcatta attactacaa tgattctgtg gggtaagtgt tgtcctcata gacaagaaag   4200

ctgaggttta gaggttaaaa tgacacattg ggggtaaata acagacacta tatgttggag   4260

ttgggaatca gatccaagtt tgactccaaa cccactttta ccacattgct tttgatctaa   4320

acttctattt tgctaaaata cccctcacag ctagtcatcc atatcattga agcgctcatg   4380

a                                                                   4381


<210>  1905
<211>  170
<212>  PRT
<213>  Homo sapiens

<400>  1905


Met Ala Ala Thr Ala Arg Glu Asp Gly Ala Ser Gly Gln Glu Arg Gly 
1               5                   10                  15      


Gln Arg Gly Cys Glu His Tyr Asp Arg Gly Cys Leu Leu Lys Ala Pro 
            20                  25                  30          


Cys Cys Asp Lys Leu Tyr Thr Cys Arg Leu Cys His Asp Asn Asn Glu 
        35                  40                  45              


Asp His Gln Leu Asp Arg Phe Lys Val Lys Glu Val Gln Cys Ile Asn 
    50                  55                  60                  


Cys Glu Lys Ile Gln His Ala Gln Gln Thr Cys Glu Glu Cys Ser Thr 
65                  70                  75                  80  


Leu Phe Gly Glu Tyr Tyr Cys Asp Ile Cys His Leu Phe Asp Lys Asp 
                85                  90                  95      


Lys Lys Gln Tyr His Cys Glu Asn Cys Gly Ile Cys Arg Ile Gly Pro 
            100                 105                 110         


Lys Glu Asp Phe Phe His Cys Leu Lys Cys Asn Leu Cys Leu Ala Met 
        115                 120                 125             


Asn Leu Gln Gly Arg His Lys Cys Ile Glu Asn Val Ser Arg Gln Asn 
    130                 135                 140                 


Cys Pro Ile Cys Leu Glu Asp Ile His Thr Ser Arg Val Val Ala His 
145                 150                 155                 160 


Val Leu Pro Cys Gly His Leu Leu His Arg 
                165                 170 

<210>  1906
<211>  1504
<212>  DNA
<213>  Homo sapiens

<400>  1906
ggtcaagagc gaggtcagcg gggctgcgag cactatgaca gaggatgtct cctaaaggtg     60

acgccttcta tggactcttc cctgacaagc ttccgtcagg caccttgctg tgacaagctt    120

tatacttgcc gcttgtgtca tgataacaat gaagatcatc aactagatcg ctttaaagtg    180

aaggaagtgc agtgcataaa ctgtgaaaaa attcaacatg cccaacagac ttgtgaagaa    240

tgtagcacat tgtttggaga atattattgc gatatatgcc atttgtttga caaagataag    300

aagcagtatc actgtgaaaa ctgtggaatt tgtaggattg gtccaaagga agattttttc    360

cattgtttga aatgtaactt atgcctagct atgaatcttc aaggaagaca caagtgtatt    420

gaaaatgtgt cccgacagaa ttgtccaata tgtttggagg acattcacac atcccgtgtt    480

gttgctcatg tcttgccatg tggacatctt ttacatagaa cgtgttatga agaaatgttg    540

aaagaaggct acagatgtcc attatgtatg cactctgctt tagatatgac caggtattgg    600

agacagctgg atgatgaagt agcacagact cctatgccat cagaatatca gaacatgact    660

gtggatattc tctgcaatga ctgtaatgga cgatccactg ttcagtttca tatattaggc    720

atgaaatgta agatttgtga atcctataat actgctcaag ctggaggacg tagaatttca    780

ctggatcagc aatgacgagc ctacacagta ctggagaact tggcattttc tgatatagaa    840

aaaggctttc cttggtatcg tgttatcatg tgtcgtcatc tatgcattag agttgatgtg    900

ttttgtacta gtgtcacagc ataaaatcat attacaagta cgtaaggatt cagggtctct    960

tgatagactt atcatagctc tatattgaat gaaagccact gtgcttgtgt tttgattgga   1020

aattccttta gtgtcagttt tttggaagcc aatgatgttt gccactgata cattcataga   1080

agtgtattat attttcatga agctttgctt taagtgacac tacgcgtgca gttcatttct   1140

agttcttgat agaactgcac ttaattttca gtagtagtct tgacttttta agggctgtgt   1200

tatattaagt tctcccttac tgttaaaacc taattaaata tgctttagaa ttttctaaga   1260

cagtcctctg gatcctctaa atgtgaattt tgatgtaata actgctaata aaattatatt   1320

gaaactgttt tatagaaagt tttttccaaa gttttctatg tttggctcaa ttagggcagt   1380

atcatcagtt ctataatgta aaagaaattt tctttctttt gaggtattcc ataaaagtag   1440

ttgggaaaat tattatgtaa aataataaga ctcttccaaa gccttaataa aaacatcaac   1500

attg                                                                1504


<210>  1907
<211>  241
<212>  PRT
<213>  Homo sapiens

<400>  1907


Met Asp Ser Ser Leu Thr Ser Phe Arg Gln Ala Pro Cys Cys Asp Lys 
1               5                   10                  15      


Leu Tyr Thr Cys Arg Leu Cys His Asp Asn Asn Glu Asp His Gln Leu 
            20                  25                  30          


Asp Arg Phe Lys Val Lys Glu Val Gln Cys Ile Asn Cys Glu Lys Ile 
        35                  40                  45              


Gln His Ala Gln Gln Thr Cys Glu Glu Cys Ser Thr Leu Phe Gly Glu 
    50                  55                  60                  


Tyr Tyr Cys Asp Ile Cys His Leu Phe Asp Lys Asp Lys Lys Gln Tyr 
65                  70                  75                  80  


His Cys Glu Asn Cys Gly Ile Cys Arg Ile Gly Pro Lys Glu Asp Phe 
                85                  90                  95      


Phe His Cys Leu Lys Cys Asn Leu Cys Leu Ala Met Asn Leu Gln Gly 
            100                 105                 110         


Arg His Lys Cys Ile Glu Asn Val Ser Arg Gln Asn Cys Pro Ile Cys 
        115                 120                 125             


Leu Glu Asp Ile His Thr Ser Arg Val Val Ala His Val Leu Pro Cys 
    130                 135                 140                 


Gly His Leu Leu His Arg Thr Cys Tyr Glu Glu Met Leu Lys Glu Gly 
145                 150                 155                 160 


Tyr Arg Cys Pro Leu Cys Met His Ser Ala Leu Asp Met Thr Arg Tyr 
                165                 170                 175     


Trp Arg Gln Leu Asp Asp Glu Val Ala Gln Thr Pro Met Pro Ser Glu 
            180                 185                 190         


Tyr Gln Asn Met Thr Val Asp Ile Leu Cys Asn Asp Cys Asn Gly Arg 
        195                 200                 205             


Ser Thr Val Gln Phe His Ile Leu Gly Met Lys Cys Lys Ile Cys Glu 
    210                 215                 220                 


Ser Tyr Asn Thr Ala Gln Ala Gly Gly Arg Arg Ile Ser Leu Asp Gln 
225                 230                 235                 240 


Gln 
    

<210>  1908
<211>  1359
<212>  DNA
<213>  Homo sapiens

<400>  1908
aggtggagga gatggcggcg acggcccggg aagatggcgc cagcggtcaa gagcgaggtc     60

agcggggctg cgagcactat gacagaggat gtctcctaaa ggcccaacag acttgtgaag    120

aatgtagcac attgtttgga gaatattatt gcgatatatg ccatttgttt gacaaagata    180

agaagcagta tcactgtgaa aactgtggaa tttgtaggat tggtccaaag gaagattttt    240

tccattgttt gaaatgtaac ttatgcctag ctatgaatct tcaaggaaga cacaagtgta    300

ttgaaaatgt gtcccgacag aattgtccaa tatgtttgga ggacattcac acatcccgtg    360

ttgttgctca tgtcttgcca tgtggacatc ttttacatag aggctacaga tgtccattat    420

gtatgcactc tgctttagat atgaccaggt attggagaca gctggatgat gaagtagcac    480

agactcctat gccatcagaa tatcagaaca tgactgtgga tattctctgc aatgactgta    540

atggacgatc cactgttcag tttcatatat taggcatgaa atgtaagatt tgtgaatcct    600

ataatactgc tcaagctgga ggacgtagaa tttcactgga tcagcaatga cgagcctaca    660

cagtactgga gaacttggca ttttctgata tagaaaaagg ctttccttgg tatcgtgtta    720

tcatgtgtcg tcatctatgc attagagttg atgtgttttg tactagtgtc acagcataaa    780

atcatattac aagtacgtaa ggattcaggg tctcttgata gacttatcat agctctatat    840

tgaatgaaag ccactgtgct tgtgttttga ttggaaattc ctttagtgtc agttttttgg    900

aagccaatga tgtttgccac tgatacattc atagaagtgt attatatttt catgaagctt    960

tgctttaagt gacactacgc gtgcagttca tttctagttc ttgatagaac tgcacttaat   1020

tttcagtagt agtcttgact ttttaagggc tgtgttatat taagttctcc cttactgtta   1080

aaacctaatt aaatatgctt tagaattttc taagacagtc ctctggatcc tctaaatgtg   1140

aattttgatg taataactgc taataaaatt atattgaaac tgttttatag aaagtttttt   1200

ccaaagtttt ctatgtttgg ctcaattagg gcagtatcat cagttctata atgtaaaaga   1260

aattttcttt cttttgaggt attccataaa agtagttggg aaaattatta tgtaaaataa   1320

taagactctt ccaaagcctt aataaaaaca tcaacattg                          1359


<210>  1909
<211>  212
<212>  PRT
<213>  Homo sapiens

<400>  1909


Met Ala Ala Thr Ala Arg Glu Asp Gly Ala Ser Gly Gln Glu Arg Gly 
1               5                   10                  15      


Gln Arg Gly Cys Glu His Tyr Asp Arg Gly Cys Leu Leu Lys Ala Gln 
            20                  25                  30          


Gln Thr Cys Glu Glu Cys Ser Thr Leu Phe Gly Glu Tyr Tyr Cys Asp 
        35                  40                  45              


Ile Cys His Leu Phe Asp Lys Asp Lys Lys Gln Tyr His Cys Glu Asn 
    50                  55                  60                  


Cys Gly Ile Cys Arg Ile Gly Pro Lys Glu Asp Phe Phe His Cys Leu 
65                  70                  75                  80  


Lys Cys Asn Leu Cys Leu Ala Met Asn Leu Gln Gly Arg His Lys Cys 
                85                  90                  95      


Ile Glu Asn Val Ser Arg Gln Asn Cys Pro Ile Cys Leu Glu Asp Ile 
            100                 105                 110         


His Thr Ser Arg Val Val Ala His Val Leu Pro Cys Gly His Leu Leu 
        115                 120                 125             


His Arg Gly Tyr Arg Cys Pro Leu Cys Met His Ser Ala Leu Asp Met 
    130                 135                 140                 


Thr Arg Tyr Trp Arg Gln Leu Asp Asp Glu Val Ala Gln Thr Pro Met 
145                 150                 155                 160 


Pro Ser Glu Tyr Gln Asn Met Thr Val Asp Ile Leu Cys Asn Asp Cys 
                165                 170                 175     


Asn Gly Arg Ser Thr Val Gln Phe His Ile Leu Gly Met Lys Cys Lys 
            180                 185                 190         


Ile Cys Glu Ser Tyr Asn Thr Ala Gln Ala Gly Gly Arg Arg Ile Ser 
        195                 200                 205             


Leu Asp Gln Gln 
    210         

<210>  1910
<211>  1595
<212>  DNA
<213>  Homo sapiens

<400>  1910
ctgccccggg tcacgtgctt aggagccata ttgtcgctag tggccgctgg ggctgggagg     60

ggtgtgctag agaggcgcag cttctctggg cgtggttttt atcctggggg aaggatcggt    120

ggaatgtgag gggaggtgga ggagatggcg gcgacggccc gggaagatgg cgccagcggt    180

caagagcgag gcaccttgct gtgacaagct ttatacttgc cgcttgtgtc atgataacaa    240

tgaagatcat caactagatc gctttaaagt gaaggaagtg cagtgcataa actgtgaaaa    300

aattcaacat gcccaacaga cttgtgaaga atgtagcaca ttgtttggag aatattattg    360

cgatatatgc catttgtttg acaaagataa gaagcagtat cactgtgaaa actgtggaat    420

ttgtaggatt ggtccaaagg aagatttttt ccattgtttg aaatgtaact tatgcctagc    480

tatgaatctt caaggaagac acaagtgtat tgaaaatgtg tcccgacaga attgtccaat    540

atgtttggag gacattcaca catcccgtgt tgttgctcat gtcttgccat gtggacatct    600

tttacataga acgtgttatg aagaaatgtt gaaagaaggc tacagatgtc cattatgtat    660

gcactctgct ttagatatga ccaggtattg gagacagctg gatgatgaag tagcacagac    720

tcctatgcca tcagaatatc agaacatgac tgtggatatt ctctgcaatg actgtaatgg    780

acgatccact gttcagtttc atatattagg catgaaatgt aagatttgtg aatcctataa    840

tactgctcaa gctggaggac gtagaatttc actggatcag caatgacgag cctacacagt    900

actggagaac ttggcatttt ctgatataga aaaaggcttt ccttggtatc gtgttatcat    960

gtgtcgtcat ctatgcatta gagttgatgt gttttgtact agtgtcacag cataaaatca   1020

tattacaagt acgtaaggat tcagggtctc ttgatagact tatcatagct ctatattgaa   1080

tgaaagccac tgtgcttgtg ttttgattgg aaattccttt agtgtcagtt ttttggaagc   1140

caatgatgtt tgccactgat acattcatag aagtgtatta tattttcatg aagctttgct   1200

ttaagtgaca ctacgcgtgc agttcatttc tagttcttga tagaactgca cttaattttc   1260

agtagtagtc ttgacttttt aagggctgtg ttatattaag ttctccctta ctgttaaaac   1320

ctaattaaat atgctttaga attttctaag acagtcctct ggatcctcta aatgtgaatt   1380

ttgatgtaat aactgctaat aaaattatat tgaaactgtt ttatagaaag ttttttccaa   1440

agttttctat gtttggctca attagggcag tatcatcagt tctataatgt aaaagaaatt   1500

ttctttcttt tgaggtattc cataaaagta gttgggaaaa ttattatgta aaataataag   1560

actcttccaa agccttaata aaaacatcaa cattg                              1595


<210>  1911
<211>  239
<212>  PRT
<213>  Homo sapiens

<400>  1911


Met Ala Pro Ala Val Lys Ser Glu Ala Pro Cys Cys Asp Lys Leu Tyr 
1               5                   10                  15      


Thr Cys Arg Leu Cys His Asp Asn Asn Glu Asp His Gln Leu Asp Arg 
            20                  25                  30          


Phe Lys Val Lys Glu Val Gln Cys Ile Asn Cys Glu Lys Ile Gln His 
        35                  40                  45              


Ala Gln Gln Thr Cys Glu Glu Cys Ser Thr Leu Phe Gly Glu Tyr Tyr 
    50                  55                  60                  


Cys Asp Ile Cys His Leu Phe Asp Lys Asp Lys Lys Gln Tyr His Cys 
65                  70                  75                  80  


Glu Asn Cys Gly Ile Cys Arg Ile Gly Pro Lys Glu Asp Phe Phe His 
                85                  90                  95      


Cys Leu Lys Cys Asn Leu Cys Leu Ala Met Asn Leu Gln Gly Arg His 
            100                 105                 110         


Lys Cys Ile Glu Asn Val Ser Arg Gln Asn Cys Pro Ile Cys Leu Glu 
        115                 120                 125             


Asp Ile His Thr Ser Arg Val Val Ala His Val Leu Pro Cys Gly His 
    130                 135                 140                 


Leu Leu His Arg Thr Cys Tyr Glu Glu Met Leu Lys Glu Gly Tyr Arg 
145                 150                 155                 160 


Cys Pro Leu Cys Met His Ser Ala Leu Asp Met Thr Arg Tyr Trp Arg 
                165                 170                 175     


Gln Leu Asp Asp Glu Val Ala Gln Thr Pro Met Pro Ser Glu Tyr Gln 
            180                 185                 190         


Asn Met Thr Val Asp Ile Leu Cys Asn Asp Cys Asn Gly Arg Ser Thr 
        195                 200                 205             


Val Gln Phe His Ile Leu Gly Met Lys Cys Lys Ile Cys Glu Ser Tyr 
    210                 215                 220                 


Asn Thr Ala Gln Ala Gly Gly Arg Arg Ile Ser Leu Asp Gln Gln 
225                 230                 235                 

<210>  1912
<211>  1894
<212>  DNA
<213>  Homo sapiens

<400>  1912
gagagaggga ggacccgtca caggtaacga tgcgcccagt gagcgtcctt tcctctgggg     60

ccaaccagcg tctccgcgcc gctgccgcca acctcgcgcc gaactacgcc ctgagatttg    120

ggcgggtagc gattggggga aaacaggcaa cctaagagtt attaccgtta gcagcgaaga    180

ctgcgactaa cgtcaacgac ggagactgcg tctgccttcg cttccgcctc gtagccccgg    240

gaaccggaaa tccgtctgcc ccgggtcacg tgcttaggag ccatattgtc gctagtggcc    300

gctggggctg ggaggggtgt gctagagagg cgcagcttct ctgggcgtgg tttttatcct    360

gggggaagga tcggtggaat gtgaggggag gtggaggaga tggcggcgac ggcccgggaa    420

gatggcgcca gcggtcaaga gcgaggtcag cggggctgcg agcactatga cagaggatgt    480

ctcctaaagg caccttgctg tgacaagctt tatacttgcc gcttgtgtca tgataacaat    540

gaagatcatc aactagatcg ctttaaagtg aaggaagtgc agtgcataaa ctgtgaaaaa    600

attcaacatg cccaacagac ttgtgaagaa tgtagcacat tgtttggaga atattattgc    660

gatatatgcc atttgtttga caaagataag aagcagtatc actgtgaaaa ctgtggaatt    720

tgtaggattg gtccaaagga agattttttc cattgtttga aatgtaactt atgcctagct    780

atgaatcttc aaggaagaca caagtgtatt gaaaatgtgt cccgacagaa ttgtccaata    840

tgtttggagg acattcacac atcccgtgtt gttgctcatg tcttgccatg tggacatctt    900

ttacatagaa cgtgttatga agaaatgttg aaagaaggct acagatgtcc attatgtatg    960

cactctgctt tagatatgac caggtattgg agacagctgg atgatgaagt agcacagact   1020

cctatgccat cagaatatca gaacatgact gtggatattc tctgcaatga ctgtaatgga   1080

cgatccactg ttcagtttca tatattaggc atgaaatgta agatttgtga atcctataat   1140

actgctcaag ctggaggacg tagaatttca ctggatcagc aatgacgagc ctacacagta   1200

ctggagaact tggcattttc tgatatagaa aaaggctttc cttggtatcg tgttatcatg   1260

tgtcgtcatc tatgcattag agttgatgtg ttttgtacta gtgtcacagc ataaaatcat   1320

attacaagta cgtaaggatt cagggtctct tgatagactt atcatagctc tatattgaat   1380

gaaagccact gtgcttgtgt tttgattgga aattccttta gtgtcagttt tttggaagcc   1440

aatgatgttt gccactgata cattcataga agtgtattat attttcatga agctttgctt   1500

taagtgacac tacgcgtgca gttcatttct agttcttgat agaactgcac ttaattttca   1560

gtagtagtct tgacttttta agggctgtgt tatattaagt tctcccttac tgttaaaacc   1620

taattaaata tgctttagaa ttttctaaga cagtcctctg gatcctctaa atgtgaattt   1680

tgatgtaata actgctaata aaattatatt gaaactgttt tatagaaagt tttttccaaa   1740

gttttctatg tttggctcaa ttagggcagt atcatcagtt ctataatgta aaagaaattt   1800

tctttctttt gaggtattcc ataaaagtag ttgggaaaat tattatgtaa aataataaga   1860

ctcttccaaa gccttaataa aaacatcaac attg                               1894


<210>  1913
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  1913


Met Ala Ala Thr Ala Arg Glu Asp Gly Ala Ser Gly Gln Glu Arg Gly 
1               5                   10                  15      


Gln Arg Gly Cys Glu His Tyr Asp Arg Gly Cys Leu Leu Lys Ala Pro 
            20                  25                  30          


Cys Cys Asp Lys Leu Tyr Thr Cys Arg Leu Cys His Asp Asn Asn Glu 
        35                  40                  45              


Asp His Gln Leu Asp Arg Phe Lys Val Lys Glu Val Gln Cys Ile Asn 
    50                  55                  60                  


Cys Glu Lys Ile Gln His Ala Gln Gln Thr Cys Glu Glu Cys Ser Thr 
65                  70                  75                  80  


Leu Phe Gly Glu Tyr Tyr Cys Asp Ile Cys His Leu Phe Asp Lys Asp 
                85                  90                  95      


Lys Lys Gln Tyr His Cys Glu Asn Cys Gly Ile Cys Arg Ile Gly Pro 
            100                 105                 110         


Lys Glu Asp Phe Phe His Cys Leu Lys Cys Asn Leu Cys Leu Ala Met 
        115                 120                 125             


Asn Leu Gln Gly Arg His Lys Cys Ile Glu Asn Val Ser Arg Gln Asn 
    130                 135                 140                 


Cys Pro Ile Cys Leu Glu Asp Ile His Thr Ser Arg Val Val Ala His 
145                 150                 155                 160 


Val Leu Pro Cys Gly His Leu Leu His Arg Thr Cys Tyr Glu Glu Met 
                165                 170                 175     


Leu Lys Glu Gly Tyr Arg Cys Pro Leu Cys Met His Ser Ala Leu Asp 
            180                 185                 190         


Met Thr Arg Tyr Trp Arg Gln Leu Asp Asp Glu Val Ala Gln Thr Pro 
        195                 200                 205             


Met Pro Ser Glu Tyr Gln Asn Met Thr Val Asp Ile Leu Cys Asn Asp 
    210                 215                 220                 


Cys Asn Gly Arg Ser Thr Val Gln Phe His Ile Leu Gly Met Lys Cys 
225                 230                 235                 240 


Lys Ile Cys Glu Ser Tyr Asn Thr Ala Gln Ala Gly Gly Arg Arg Ile 
                245                 250                 255     


Ser Leu Asp Gln Gln 
            260     

<210>  1914
<211>  2889
<212>  DNA
<213>  Homo sapiens

<400>  1914
gagagaggga ggacccgtca caggtaacga tgcgcccagt gagcgtcctt tcctctgggg     60

ccaaccagcg tctccgcgcc gctgccgcca acctcgcgcc gaactacgcc ctgagatttg    120

ggcgggtagc gattggggga aaacaggcaa cctaagagtt attaccgtta gcagcgaaga    180

ctgcgactaa cgtcaacgac ggagactgcg tctgccttcg cttccgcctc gtagccccgg    240

gaaccggaaa tccgtctgcc ccgggtcacg tgcttaggag ccatattgtc gctagtggcc    300

gctggggctg ggaggggtgt gctagagagg cgcagcttct ctgggcgtgg tttttatcct    360

gggggaagga tcggtggaat gtgaggggag gtggaggaga tggcggcgac ggcccgggaa    420

gatggcgcca gcggtcaaga gcgaggtcag cggggctgcg agcactatga cagaggatgt    480

ctcctaaagg caccttgctg tgacaagctt tatacttgcc gcttgtgtca tgataacaat    540

gaagatcatc aactagatcg ctttaaagtg aaggaagtgc agtgcataaa ctgtgaaaaa    600

attcaacatg cccaacagac ttgtgaagaa tgtagcacat tgtttggaga atattattgc    660

gatatatgcc atttgtttga caaagataag aagcagtatc actgtgaaaa ctgtggaatt    720

tgtaggattg gtccaaagga agattttttc cattgtttga aatgtaactt atgcctagct    780

atgaatcttc aaggaagaca caagtgtatt gaaaatgtgt cccgacagaa ttgtccaata    840

tgtttggagg acattcacac atcccgtgtt gttgctcatg tcttgccatg tggacatctt    900

ttacataggt aaagtaacat ctttttctca atgatgtttg aaaatagtgg agacagtttt    960

tgttttacta aaataatctt atattttctt tcagaacgtg ttatgaagaa atgttgaaag   1020

agtgagtgtt tgggatttta aaaataattg taagatgttt gacttttttg tgtgtgtggt   1080

gtggggaggt ggacaaacat tgttacttat actatattgg gcatggcaat atttatattg   1140

aaatgggtag ggtagatgaa tattgttaaa acaggacaaa gtgtcttgga tatagaacta   1200

cacttttgcc atatgtttct cttaaatctt gtctcctccc acaatttgag gtagttacct   1260

cttttttttc tggccatata taccaggaag tgcagttttt gccagatgca gttatagtgt   1320

tgtaaaaatg ctgaaaaata ttgccaaaaa tttgttaggt tgttatattg gccaagtata   1380

gtaaactaaa agaaagtagg tgaagtgatc attaaagcta agactttatt aatggaaaag   1440

atattaaaat tagatgaaaa taattgaaaa gagaagactg tattttggtc ctacatattg   1500

atgagcaaaa atgtgaagag ctagagagag cattcttttt ttcaaatttt tagaaaggaa   1560

ataatatctg aataatttta aacaaataca gtctctttac atgagtgtat taagaaatta   1620

aggttgttta gataaggagt agcttaatta gtttataaaa atatatgaag tgtattctac   1680

aaagaatatg gactaattcc tctccatttt agagtactga ggaaaaagac ttagttttaa   1740

ataagtatac aggaattaat ttaaaagttt tatagtgtga aagttcccag gttcctaaga   1800

gattatcttg aaatggagga aaatgcctgt tttgaatggt tcatgtggca gttagcctgc   1860

atcttcttgt atacctgaat taatatattc ttgtttaata tttggaaaat aacctttcta   1920

tctctttcag aggctacaga tgtccattat gtatgcactc tgctttagat atgaccaggt   1980

attggagaca gctggatgat gaagtagcac agactcctat gccatcagaa tatcagaaca   2040

tgactgtgga tattctctgc aatgactgta atggacgatc cactgttcag tttcatatat   2100

taggcatgaa atgtaagatt tgtgaatcct ataatactgc tcaagctgga ggacgtagaa   2160

tttcactgga tcagcaatga cgagcctaca cagtactgga gaacttggca ttttctgata   2220

tagaaaaagg ctttccttgg tatcgtgtta tcatgtgtcg tcatctatgc attagagttg   2280

atgtgttttg tactagtgtc acagcataaa atcatattac aagtacgtaa ggattcaggg   2340

tctcttgata gacttatcat agctctatat tgaatgaaag ccactgtgct tgtgttttga   2400

ttggaaattc ctttagtgtc agttttttgg aagccaatga tgtttgccac tgatacattc   2460

atagaagtgt attatatttt catgaagctt tgctttaagt gacactacgc gtgcagttca   2520

tttctagttc ttgatagaac tgcacttaat tttcagtagt agtcttgact ttttaagggc   2580

tgtgttatat taagttctcc cttactgtta aaacctaatt aaatatgctt tagaattttc   2640

taagacagtc ctctggatcc tctaaatgtg aattttgatg taataactgc taataaaatt   2700

atattgaaac tgttttatag aaagtttttt ccaaagtttt ctatgtttgg ctcaattagg   2760

gcagtatcat cagttctata atgtaaaaga aattttcttt cttttgaggt attccataaa   2820

agtagttggg aaaattatta tgtaaaataa taagactctt ccaaagcctt aataaaaaca   2880

tcaacattg                                                           2889


<210>  1915
<211>  170
<212>  PRT
<213>  Homo sapiens

<400>  1915


Met Ala Ala Thr Ala Arg Glu Asp Gly Ala Ser Gly Gln Glu Arg Gly 
1               5                   10                  15      


Gln Arg Gly Cys Glu His Tyr Asp Arg Gly Cys Leu Leu Lys Ala Pro 
            20                  25                  30          


Cys Cys Asp Lys Leu Tyr Thr Cys Arg Leu Cys His Asp Asn Asn Glu 
        35                  40                  45              


Asp His Gln Leu Asp Arg Phe Lys Val Lys Glu Val Gln Cys Ile Asn 
    50                  55                  60                  


Cys Glu Lys Ile Gln His Ala Gln Gln Thr Cys Glu Glu Cys Ser Thr 
65                  70                  75                  80  


Leu Phe Gly Glu Tyr Tyr Cys Asp Ile Cys His Leu Phe Asp Lys Asp 
                85                  90                  95      


Lys Lys Gln Tyr His Cys Glu Asn Cys Gly Ile Cys Arg Ile Gly Pro 
            100                 105                 110         


Lys Glu Asp Phe Phe His Cys Leu Lys Cys Asn Leu Cys Leu Ala Met 
        115                 120                 125             


Asn Leu Gln Gly Arg His Lys Cys Ile Glu Asn Val Ser Arg Gln Asn 
    130                 135                 140                 


Cys Pro Ile Cys Leu Glu Asp Ile His Thr Ser Arg Val Val Ala His 
145                 150                 155                 160 


Val Leu Pro Cys Gly His Leu Leu His Arg 
                165                 170 

<210>  1916
<211>  1335
<212>  DNA
<213>  Homo sapiens

<400>  1916
ggtcaagagc gaggtcagcg gggctgcgag cactatgaca gaggatgtct cctaaaggtg     60

acgccttcta tggactcttc cctgacaagc ttccgtcagg caccttgctg tgacaagctt    120

tatacttgcc gcttgtgtca tgataacaat gaagatcatc aactagatcg ctttaaagtg    180

aaggaagtgc agtgcataaa ctgtgaaaaa attcaacatg cccaacagac ttgtgaagaa    240

tgtagcacat tgtttggaga atattattgc gatatatgcc atttgtttga caaagataag    300

aagcagtatc actgtgaaaa ctgtggaatt tgtaggattg gtccaaagga agattttttc    360

cattgtttga aatgtaactt atgcctagct atgaatcttc aaggaagaca caagtgtatt    420

gaaaatgtgt cccgacagaa ttgtccaata tgtttggagg acattcacac atcccgtgtt    480

gttgctcatg tcttgccatg tggacatctt ttacatagaa cgtgttatga agaaatgttg    540

aaagaaggct acagatgtcc attatgtatg cactctgctt tagatatgac caggtattgg    600

agacagctgg atgatgaagt agcacagact cctatgccat cagaatatca gaacatgact    660

gtggatattc tctgcaatga ctgtaatgga cgatccactg ttcagtttca tatattaggc    720

atgaaatgta agatttgtga atcctataat actgctcaag ctggaggacg tagaatttca    780

ctggatcagc aatgacgagc ctacacagta ctggagaact tggcattttc tgatatagaa    840

aaaggctttc cttggtatcg tgttatcatg tgtcgtcatc tatgcattag agttgatgtg    900

ttttgtacta gtgtcacagc ataaaatcat attacaagta cgtaaggatt cagggtctct    960

tgatagactt atcatagctc tatattgaat gaaagccact gtgcttgtgt tttgattgga   1020

aattccttta gtgtcagttt tttggaagcc aatgatgttt gccactgata cattcataga   1080

agtgtattat attttcatga agctttgctt taagtgacac tacgcgtgca gttcatttct   1140

agttcttgat agaactgcac ttaattttca gtagtagtct tgacttttta agggctgtgt   1200

tatattaagt tctcccttac tgttaaaacc taattaaata tgctttagaa ttttctaaga   1260

cagtcctctg gatcctctaa atgtgaattt tgatgtaata actgctaata aaattatatt   1320

gaaactgttt tatag                                                    1335


<210>  1917
<211>  241
<212>  PRT
<213>  Homo sapiens

<400>  1917


Met Asp Ser Ser Leu Thr Ser Phe Arg Gln Ala Pro Cys Cys Asp Lys 
1               5                   10                  15      


Leu Tyr Thr Cys Arg Leu Cys His Asp Asn Asn Glu Asp His Gln Leu 
            20                  25                  30          


Asp Arg Phe Lys Val Lys Glu Val Gln Cys Ile Asn Cys Glu Lys Ile 
        35                  40                  45              


Gln His Ala Gln Gln Thr Cys Glu Glu Cys Ser Thr Leu Phe Gly Glu 
    50                  55                  60                  


Tyr Tyr Cys Asp Ile Cys His Leu Phe Asp Lys Asp Lys Lys Gln Tyr 
65                  70                  75                  80  


His Cys Glu Asn Cys Gly Ile Cys Arg Ile Gly Pro Lys Glu Asp Phe 
                85                  90                  95      


Phe His Cys Leu Lys Cys Asn Leu Cys Leu Ala Met Asn Leu Gln Gly 
            100                 105                 110         


Arg His Lys Cys Ile Glu Asn Val Ser Arg Gln Asn Cys Pro Ile Cys 
        115                 120                 125             


Leu Glu Asp Ile His Thr Ser Arg Val Val Ala His Val Leu Pro Cys 
    130                 135                 140                 


Gly His Leu Leu His Arg Thr Cys Tyr Glu Glu Met Leu Lys Glu Gly 
145                 150                 155                 160 


Tyr Arg Cys Pro Leu Cys Met His Ser Ala Leu Asp Met Thr Arg Tyr 
                165                 170                 175     


Trp Arg Gln Leu Asp Asp Glu Val Ala Gln Thr Pro Met Pro Ser Glu 
            180                 185                 190         


Tyr Gln Asn Met Thr Val Asp Ile Leu Cys Asn Asp Cys Asn Gly Arg 
        195                 200                 205             


Ser Thr Val Gln Phe His Ile Leu Gly Met Lys Cys Lys Ile Cys Glu 
    210                 215                 220                 


Ser Tyr Asn Thr Ala Gln Ala Gly Gly Arg Arg Ile Ser Leu Asp Gln 
225                 230                 235                 240 


Gln 
    

<210>  1918
<211>  1190
<212>  DNA
<213>  Homo sapiens

<400>  1918
aggtggagga gatggcggcg acggcccggg aagatggcgc cagcggtcaa gagcgaggtc     60

agcggggctg cgagcactat gacagaggat gtctcctaaa ggcccaacag acttgtgaag    120

aatgtagcac attgtttgga gaatattatt gcgatatatg ccatttgttt gacaaagata    180

agaagcagta tcactgtgaa aactgtggaa tttgtaggat tggtccaaag gaagattttt    240

tccattgttt gaaatgtaac ttatgcctag ctatgaatct tcaaggaaga cacaagtgta    300

ttgaaaatgt gtcccgacag aattgtccaa tatgtttgga ggacattcac acatcccgtg    360

ttgttgctca tgtcttgcca tgtggacatc ttttacatag aggctacaga tgtccattat    420

gtatgcactc tgctttagat atgaccaggt attggagaca gctggatgat gaagtagcac    480

agactcctat gccatcagaa tatcagaaca tgactgtgga tattctctgc aatgactgta    540

atggacgatc cactgttcag tttcatatat taggcatgaa atgtaagatt tgtgaatcct    600

ataatactgc tcaagctgga ggacgtagaa tttcactgga tcagcaatga cgagcctaca    660

cagtactgga gaacttggca ttttctgata tagaaaaagg ctttccttgg tatcgtgtta    720

tcatgtgtcg tcatctatgc attagagttg atgtgttttg tactagtgtc acagcataaa    780

atcatattac aagtacgtaa ggattcaggg tctcttgata gacttatcat agctctatat    840

tgaatgaaag ccactgtgct tgtgttttga ttggaaattc ctttagtgtc agttttttgg    900

aagccaatga tgtttgccac tgatacattc atagaagtgt attatatttt catgaagctt    960

tgctttaagt gacactacgc gtgcagttca tttctagttc ttgatagaac tgcacttaat   1020

tttcagtagt agtcttgact ttttaagggc tgtgttatat taagttctcc cttactgtta   1080

aaacctaatt aaatatgctt tagaattttc taagacagtc ctctggatcc tctaaatgtg   1140

aattttgatg taataactgc taataaaatt atattgaaac tgttttatag              1190


<210>  1919
<211>  212
<212>  PRT
<213>  Homo sapiens

<400>  1919


Met Ala Ala Thr Ala Arg Glu Asp Gly Ala Ser Gly Gln Glu Arg Gly 
1               5                   10                  15      


Gln Arg Gly Cys Glu His Tyr Asp Arg Gly Cys Leu Leu Lys Ala Gln 
            20                  25                  30          


Gln Thr Cys Glu Glu Cys Ser Thr Leu Phe Gly Glu Tyr Tyr Cys Asp 
        35                  40                  45              


Ile Cys His Leu Phe Asp Lys Asp Lys Lys Gln Tyr His Cys Glu Asn 
    50                  55                  60                  


Cys Gly Ile Cys Arg Ile Gly Pro Lys Glu Asp Phe Phe His Cys Leu 
65                  70                  75                  80  


Lys Cys Asn Leu Cys Leu Ala Met Asn Leu Gln Gly Arg His Lys Cys 
                85                  90                  95      


Ile Glu Asn Val Ser Arg Gln Asn Cys Pro Ile Cys Leu Glu Asp Ile 
            100                 105                 110         


His Thr Ser Arg Val Val Ala His Val Leu Pro Cys Gly His Leu Leu 
        115                 120                 125             


His Arg Gly Tyr Arg Cys Pro Leu Cys Met His Ser Ala Leu Asp Met 
    130                 135                 140                 


Thr Arg Tyr Trp Arg Gln Leu Asp Asp Glu Val Ala Gln Thr Pro Met 
145                 150                 155                 160 


Pro Ser Glu Tyr Gln Asn Met Thr Val Asp Ile Leu Cys Asn Asp Cys 
                165                 170                 175     


Asn Gly Arg Ser Thr Val Gln Phe His Ile Leu Gly Met Lys Cys Lys 
            180                 185                 190         


Ile Cys Glu Ser Tyr Asn Thr Ala Gln Ala Gly Gly Arg Arg Ile Ser 
        195                 200                 205             


Leu Asp Gln Gln 
    210         

<210>  1920
<211>  1426
<212>  DNA
<213>  Homo sapiens

<400>  1920
ctgccccggg tcacgtgctt aggagccata ttgtcgctag tggccgctgg ggctgggagg     60

ggtgtgctag agaggcgcag cttctctggg cgtggttttt atcctggggg aaggatcggt    120

ggaatgtgag gggaggtgga ggagatggcg gcgacggccc gggaagatgg cgccagcggt    180

caagagcgag gcaccttgct gtgacaagct ttatacttgc cgcttgtgtc atgataacaa    240

tgaagatcat caactagatc gctttaaagt gaaggaagtg cagtgcataa actgtgaaaa    300

aattcaacat gcccaacaga cttgtgaaga atgtagcaca ttgtttggag aatattattg    360

cgatatatgc catttgtttg acaaagataa gaagcagtat cactgtgaaa actgtggaat    420

ttgtaggatt ggtccaaagg aagatttttt ccattgtttg aaatgtaact tatgcctagc    480

tatgaatctt caaggaagac acaagtgtat tgaaaatgtg tcccgacaga attgtccaat    540

atgtttggag gacattcaca catcccgtgt tgttgctcat gtcttgccat gtggacatct    600

tttacataga acgtgttatg aagaaatgtt gaaagaaggc tacagatgtc cattatgtat    660

gcactctgct ttagatatga ccaggtattg gagacagctg gatgatgaag tagcacagac    720

tcctatgcca tcagaatatc agaacatgac tgtggatatt ctctgcaatg actgtaatgg    780

acgatccact gttcagtttc atatattagg catgaaatgt aagatttgtg aatcctataa    840

tactgctcaa gctggaggac gtagaatttc actggatcag caatgacgag cctacacagt    900

actggagaac ttggcatttt ctgatataga aaaaggcttt ccttggtatc gtgttatcat    960

gtgtcgtcat ctatgcatta gagttgatgt gttttgtact agtgtcacag cataaaatca   1020

tattacaagt acgtaaggat tcagggtctc ttgatagact tatcatagct ctatattgaa   1080

tgaaagccac tgtgcttgtg ttttgattgg aaattccttt agtgtcagtt ttttggaagc   1140

caatgatgtt tgccactgat acattcatag aagtgtatta tattttcatg aagctttgct   1200

ttaagtgaca ctacgcgtgc agttcatttc tagttcttga tagaactgca cttaattttc   1260

agtagtagtc ttgacttttt aagggctgtg ttatattaag ttctccctta ctgttaaaac   1320

ctaattaaat atgctttaga attttctaag acagtcctct ggatcctcta aatgtgaatt   1380

ttgatgtaat aactgctaat aaaattatat tgaaactgtt ttatag                  1426


<210>  1921
<211>  239
<212>  PRT
<213>  Homo sapiens

<400>  1921


Met Ala Pro Ala Val Lys Ser Glu Ala Pro Cys Cys Asp Lys Leu Tyr 
1               5                   10                  15      


Thr Cys Arg Leu Cys His Asp Asn Asn Glu Asp His Gln Leu Asp Arg 
            20                  25                  30          


Phe Lys Val Lys Glu Val Gln Cys Ile Asn Cys Glu Lys Ile Gln His 
        35                  40                  45              


Ala Gln Gln Thr Cys Glu Glu Cys Ser Thr Leu Phe Gly Glu Tyr Tyr 
    50                  55                  60                  


Cys Asp Ile Cys His Leu Phe Asp Lys Asp Lys Lys Gln Tyr His Cys 
65                  70                  75                  80  


Glu Asn Cys Gly Ile Cys Arg Ile Gly Pro Lys Glu Asp Phe Phe His 
                85                  90                  95      


Cys Leu Lys Cys Asn Leu Cys Leu Ala Met Asn Leu Gln Gly Arg His 
            100                 105                 110         


Lys Cys Ile Glu Asn Val Ser Arg Gln Asn Cys Pro Ile Cys Leu Glu 
        115                 120                 125             


Asp Ile His Thr Ser Arg Val Val Ala His Val Leu Pro Cys Gly His 
    130                 135                 140                 


Leu Leu His Arg Thr Cys Tyr Glu Glu Met Leu Lys Glu Gly Tyr Arg 
145                 150                 155                 160 


Cys Pro Leu Cys Met His Ser Ala Leu Asp Met Thr Arg Tyr Trp Arg 
                165                 170                 175     


Gln Leu Asp Asp Glu Val Ala Gln Thr Pro Met Pro Ser Glu Tyr Gln 
            180                 185                 190         


Asn Met Thr Val Asp Ile Leu Cys Asn Asp Cys Asn Gly Arg Ser Thr 
        195                 200                 205             


Val Gln Phe His Ile Leu Gly Met Lys Cys Lys Ile Cys Glu Ser Tyr 
    210                 215                 220                 


Asn Thr Ala Gln Ala Gly Gly Arg Arg Ile Ser Leu Asp Gln Gln 
225                 230                 235                 

<210>  1922
<211>  2720
<212>  DNA
<213>  Homo sapiens

<400>  1922
gagagaggga ggacccgtca caggtaacga tgcgcccagt gagcgtcctt tcctctgggg     60

ccaaccagcg tctccgcgcc gctgccgcca acctcgcgcc gaactacgcc ctgagatttg    120

ggcgggtagc gattggggga aaacaggcaa cctaagagtt attaccgtta gcagcgaaga    180

ctgcgactaa cgtcaacgac ggagactgcg tctgccttcg cttccgcctc gtagccccgg    240

gaaccggaaa tccgtctgcc ccgggtcacg tgcttaggag ccatattgtc gctagtggcc    300

gctggggctg ggaggggtgt gctagagagg cgcagcttct ctgggcgtgg tttttatcct    360

gggggaagga tcggtggaat gtgaggggag gtggaggaga tggcggcgac ggcccgggaa    420

gatggcgcca gcggtcaaga gcgaggtcag cggggctgcg agcactatga cagaggatgt    480

ctcctaaagg caccttgctg tgacaagctt tatacttgcc gcttgtgtca tgataacaat    540

gaagatcatc aactagatcg ctttaaagtg aaggaagtgc agtgcataaa ctgtgaaaaa    600

attcaacatg cccaacagac ttgtgaagaa tgtagcacat tgtttggaga atattattgc    660

gatatatgcc atttgtttga caaagataag aagcagtatc actgtgaaaa ctgtggaatt    720

tgtaggattg gtccaaagga agattttttc cattgtttga aatgtaactt atgcctagct    780

atgaatcttc aaggaagaca caagtgtatt gaaaatgtgt cccgacagaa ttgtccaata    840

tgtttggagg acattcacac atcccgtgtt gttgctcatg tcttgccatg tggacatctt    900

ttacataggt aaagtaacat ctttttctca atgatgtttg aaaatagtgg agacagtttt    960

tgttttacta aaataatctt atattttctt tcagaacgtg ttatgaagaa atgttgaaag   1020

agtgagtgtt tgggatttta aaaataattg taagatgttt gacttttttg tgtgtgtggt   1080

gtggggaggt ggacaaacat tgttacttat actatattgg gcatggcaat atttatattg   1140

aaatgggtag ggtagatgaa tattgttaaa acaggacaaa gtgtcttgga tatagaacta   1200

cacttttgcc atatgtttct cttaaatctt gtctcctccc acaatttgag gtagttacct   1260

cttttttttc tggccatata taccaggaag tgcagttttt gccagatgca gttatagtgt   1320

tgtaaaaatg ctgaaaaata ttgccaaaaa tttgttaggt tgttatattg gccaagtata   1380

gtaaactaaa agaaagtagg tgaagtgatc attaaagcta agactttatt aatggaaaag   1440

atattaaaat tagatgaaaa taattgaaaa gagaagactg tattttggtc ctacatattg   1500

atgagcaaaa atgtgaagag ctagagagag cattcttttt ttcaaatttt tagaaaggaa   1560

ataatatctg aataatttta aacaaataca gtctctttac atgagtgtat taagaaatta   1620

aggttgttta gataaggagt agcttaatta gtttataaaa atatatgaag tgtattctac   1680

aaagaatatg gactaattcc tctccatttt agagtactga ggaaaaagac ttagttttaa   1740

ataagtatac aggaattaat ttaaaagttt tatagtgtga aagttcccag gttcctaaga   1800

gattatcttg aaatggagga aaatgcctgt tttgaatggt tcatgtggca gttagcctgc   1860

atcttcttgt atacctgaat taatatattc ttgtttaata tttggaaaat aacctttcta   1920

tctctttcag aggctacaga tgtccattat gtatgcactc tgctttagat atgaccaggt   1980

attggagaca gctggatgat gaagtagcac agactcctat gccatcagaa tatcagaaca   2040

tgactgtgga tattctctgc aatgactgta atggacgatc cactgttcag tttcatatat   2100

taggcatgaa atgtaagatt tgtgaatcct ataatactgc tcaagctgga ggacgtagaa   2160

tttcactgga tcagcaatga cgagcctaca cagtactgga gaacttggca ttttctgata   2220

tagaaaaagg ctttccttgg tatcgtgtta tcatgtgtcg tcatctatgc attagagttg   2280

atgtgttttg tactagtgtc acagcataaa atcatattac aagtacgtaa ggattcaggg   2340

tctcttgata gacttatcat agctctatat tgaatgaaag ccactgtgct tgtgttttga   2400

ttggaaattc ctttagtgtc agttttttgg aagccaatga tgtttgccac tgatacattc   2460

atagaagtgt attatatttt catgaagctt tgctttaagt gacactacgc gtgcagttca   2520

tttctagttc ttgatagaac tgcacttaat tttcagtagt agtcttgact ttttaagggc   2580

tgtgttatat taagttctcc cttactgtta aaacctaatt aaatatgctt tagaattttc   2640

taagacagtc ctctggatcc tctaaatgtg aattttgatg taataactgc taataaaatt   2700

atattgaaac tgttttatag                                               2720


<210>  1923
<211>  170
<212>  PRT
<213>  Homo sapiens

<400>  1923


Met Ala Ala Thr Ala Arg Glu Asp Gly Ala Ser Gly Gln Glu Arg Gly 
1               5                   10                  15      


Gln Arg Gly Cys Glu His Tyr Asp Arg Gly Cys Leu Leu Lys Ala Pro 
            20                  25                  30          


Cys Cys Asp Lys Leu Tyr Thr Cys Arg Leu Cys His Asp Asn Asn Glu 
        35                  40                  45              


Asp His Gln Leu Asp Arg Phe Lys Val Lys Glu Val Gln Cys Ile Asn 
    50                  55                  60                  


Cys Glu Lys Ile Gln His Ala Gln Gln Thr Cys Glu Glu Cys Ser Thr 
65                  70                  75                  80  


Leu Phe Gly Glu Tyr Tyr Cys Asp Ile Cys His Leu Phe Asp Lys Asp 
                85                  90                  95      


Lys Lys Gln Tyr His Cys Glu Asn Cys Gly Ile Cys Arg Ile Gly Pro 
            100                 105                 110         


Lys Glu Asp Phe Phe His Cys Leu Lys Cys Asn Leu Cys Leu Ala Met 
        115                 120                 125             


Asn Leu Gln Gly Arg His Lys Cys Ile Glu Asn Val Ser Arg Gln Asn 
    130                 135                 140                 


Cys Pro Ile Cys Leu Glu Asp Ile His Thr Ser Arg Val Val Ala His 
145                 150                 155                 160 


Val Leu Pro Cys Gly His Leu Leu His Arg 
                165                 170 

<210>  1924
<211>  1725
<212>  DNA
<213>  Homo sapiens

<400>  1924
gagagaggga ggacccgtca caggtaacga tgcgcccagt gagcgtcctt tcctctgggg     60

ccaaccagcg tctccgcgcc gctgccgcca acctcgcgcc gaactacgcc ctgagatttg    120

ggcgggtagc gattggggga aaacaggcaa cctaagagtt attaccgtta gcagcgaaga    180

ctgcgactaa cgtcaacgac ggagactgcg tctgccttcg cttccgcctc gtagccccgg    240

gaaccggaaa tccgtctgcc ccgggtcacg tgcttaggag ccatattgtc gctagtggcc    300

gctggggctg ggaggggtgt gctagagagg cgcagcttct ctgggcgtgg tttttatcct    360

gggggaagga tcggtggaat gtgaggggag gtggaggaga tggcggcgac ggcccgggaa    420

gatggcgcca gcggtcaaga gcgaggtcag cggggctgcg agcactatga cagaggatgt    480

ctcctaaagg caccttgctg tgacaagctt tatacttgcc gcttgtgtca tgataacaat    540

gaagatcatc aactagatcg ctttaaagtg aaggaagtgc agtgcataaa ctgtgaaaaa    600

attcaacatg cccaacagac ttgtgaagaa tgtagcacat tgtttggaga atattattgc    660

gatatatgcc atttgtttga caaagataag aagcagtatc actgtgaaaa ctgtggaatt    720

tgtaggattg gtccaaagga agattttttc cattgtttga aatgtaactt atgcctagct    780

atgaatcttc aaggaagaca caagtgtatt gaaaatgtgt cccgacagaa ttgtccaata    840

tgtttggagg acattcacac atcccgtgtt gttgctcatg tcttgccatg tggacatctt    900

ttacatagaa cgtgttatga agaaatgttg aaagaaggct acagatgtcc attatgtatg    960

cactctgctt tagatatgac caggtattgg agacagctgg atgatgaagt agcacagact   1020

cctatgccat cagaatatca gaacatgact gtggatattc tctgcaatga ctgtaatgga   1080

cgatccactg ttcagtttca tatattaggc atgaaatgta agatttgtga atcctataat   1140

actgctcaag ctggaggacg tagaatttca ctggatcagc aatgacgagc ctacacagta   1200

ctggagaact tggcattttc tgatatagaa aaaggctttc cttggtatcg tgttatcatg   1260

tgtcgtcatc tatgcattag agttgatgtg ttttgtacta gtgtcacagc ataaaatcat   1320

attacaagta cgtaaggatt cagggtctct tgatagactt atcatagctc tatattgaat   1380

gaaagccact gtgcttgtgt tttgattgga aattccttta gtgtcagttt tttggaagcc   1440

aatgatgttt gccactgata cattcataga agtgtattat attttcatga agctttgctt   1500

taagtgacac tacgcgtgca gttcatttct agttcttgat agaactgcac ttaattttca   1560

gtagtagtct tgacttttta agggctgtgt tatattaagt tctcccttac tgttaaaacc   1620

taattaaata tgctttagaa ttttctaaga cagtcctctg gatcctctaa atgtgaattt   1680

tgatgtaata actgctaata aaattatatt gaaactgttt tatag                   1725


<210>  1925
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  1925


Met Ala Ala Thr Ala Arg Glu Asp Gly Ala Ser Gly Gln Glu Arg Gly 
1               5                   10                  15      


Gln Arg Gly Cys Glu His Tyr Asp Arg Gly Cys Leu Leu Lys Ala Pro 
            20                  25                  30          


Cys Cys Asp Lys Leu Tyr Thr Cys Arg Leu Cys His Asp Asn Asn Glu 
        35                  40                  45              


Asp His Gln Leu Asp Arg Phe Lys Val Lys Glu Val Gln Cys Ile Asn 
    50                  55                  60                  


Cys Glu Lys Ile Gln His Ala Gln Gln Thr Cys Glu Glu Cys Ser Thr 
65                  70                  75                  80  


Leu Phe Gly Glu Tyr Tyr Cys Asp Ile Cys His Leu Phe Asp Lys Asp 
                85                  90                  95      


Lys Lys Gln Tyr His Cys Glu Asn Cys Gly Ile Cys Arg Ile Gly Pro 
            100                 105                 110         


Lys Glu Asp Phe Phe His Cys Leu Lys Cys Asn Leu Cys Leu Ala Met 
        115                 120                 125             


Asn Leu Gln Gly Arg His Lys Cys Ile Glu Asn Val Ser Arg Gln Asn 
    130                 135                 140                 


Cys Pro Ile Cys Leu Glu Asp Ile His Thr Ser Arg Val Val Ala His 
145                 150                 155                 160 


Val Leu Pro Cys Gly His Leu Leu His Arg Thr Cys Tyr Glu Glu Met 
                165                 170                 175     


Leu Lys Glu Gly Tyr Arg Cys Pro Leu Cys Met His Ser Ala Leu Asp 
            180                 185                 190         


Met Thr Arg Tyr Trp Arg Gln Leu Asp Asp Glu Val Ala Gln Thr Pro 
        195                 200                 205             


Met Pro Ser Glu Tyr Gln Asn Met Thr Val Asp Ile Leu Cys Asn Asp 
    210                 215                 220                 


Cys Asn Gly Arg Ser Thr Val Gln Phe His Ile Leu Gly Met Lys Cys 
225                 230                 235                 240 


Lys Ile Cys Glu Ser Tyr Asn Thr Ala Gln Ala Gly Gly Arg Arg Ile 
                245                 250                 255     


Ser Leu Asp Gln Gln 
            260     

<210>  1926
<211>  1687
<212>  DNA
<213>  Homo sapiens

<400>  1926
gagagaggga ggacccgtca caggtaacga tgcgcccagt gagcgtcctt tcctctgggg     60

ccaaccagcg tctccgcgcc gctgccgcca acctcgcgcc gaactacgcc ctgagatttg    120

ggcgggtagc gattggggga aaacaggcaa cctaagagtt attaccgtta gcagcgaaga    180

ctgcgactaa cgtcaacgac ggagactgcg tctgccttcg cttccgcctc gtagccccgg    240

gaaccggaaa tccgtctgcc ccgggtcacg tgcttaggag ccatattgtc gctagtggcc    300

gctggggctg ggaggggtgt gctagagagg cgcagcttct ctgggcgtgg tttttatcct    360

gggggaagga tcggtggaat gtgaggggag gtggaggaga tggcggcgac ggcccgggaa    420

gatggcgcca gcggtcaaga gcgaggtcag cggggctgcg agcactatga cagaggatgt    480

ctcctaaagg caccttgctg tgacaagctt tatacttgcc gcttgtgtca tgataacaat    540

gaagatcatc aactagatcg ctttaaagtg aaggaagtgc agtgcataaa ctgtgaaaaa    600

attcaacatg cccaacagac ttgtgaagaa tgtagcacat tgtttggaga atattattgc    660

gatatatgcc atttgtttga caaagataag aagcagtatc actgtgaaaa ctgtggaatt    720

tgtaggattg gtccaaagga agattttttc cattgtttga aatgtaactt atgcctagct    780

atgaatcttc aaggaagaca caagtgtatt gaaaatgtgt cccgacagaa ttgtccaata    840

tgtttggagg acattcacac atcccgtgtt gttgctcatg tcttgccatg tggacatctt    900

ttacatagaa cgtgttatga agaaatgttg aaagaatatg accaggtatt ggagacagct    960

ggatgatgaa gtagcacaga ctcctatgcc atcagaatat cagaacatga ctgtggatat   1020

tctctgcaat gactgtaatg gacgatccac tgttcagttt catatattag gcatgaaatg   1080

taagatttgt gaatcctata atactgctca agctggagga cgtagaattt cactggatca   1140

gcaatgacga gcctacacag tactggagaa cttggcattt tctgatatag aaaaaggctt   1200

tccttggtat cgtgttatca tgtgtcgtca tctatgcatt agagttgatg tgttttgtac   1260

tagtgtcaca gcataaaatc atattacaag tacgtaagga ttcagggtct cttgatagac   1320

ttatcatagc tctatattga atgaaagcca ctgtgcttgt gttttgattg gaaattcctt   1380

tagtgtcagt tttttggaag ccaatgatgt ttgccactga tacattcata gaagtgtatt   1440

atattttcat gaagctttgc tttaagtgac actacgcgtg cagttcattt ctagttcttg   1500

atagaactgc acttaatttt cagtagtagt cttgactttt taagggctgt gttatattaa   1560

gttctccctt actgttaaaa cctaattaaa tatgctttag aattttctaa gacagtcctc   1620

tggatcctct aaatgtgaat tttgatgtaa taactgctaa taaaattata ttgaaactgt   1680

tttatag                                                             1687


<210>  1927
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  1927


Met Ala Ala Thr Ala Arg Glu Asp Gly Ala Ser Gly Gln Glu Arg Gly 
1               5                   10                  15      


Gln Arg Gly Cys Glu His Tyr Asp Arg Gly Cys Leu Leu Lys Ala Pro 
            20                  25                  30          


Cys Cys Asp Lys Leu Tyr Thr Cys Arg Leu Cys His Asp Asn Asn Glu 
        35                  40                  45              


Asp His Gln Leu Asp Arg Phe Lys Val Lys Glu Val Gln Cys Ile Asn 
    50                  55                  60                  


Cys Glu Lys Ile Gln His Ala Gln Gln Thr Cys Glu Glu Cys Ser Thr 
65                  70                  75                  80  


Leu Phe Gly Glu Tyr Tyr Cys Asp Ile Cys His Leu Phe Asp Lys Asp 
                85                  90                  95      


Lys Lys Gln Tyr His Cys Glu Asn Cys Gly Ile Cys Arg Ile Gly Pro 
            100                 105                 110         


Lys Glu Asp Phe Phe His Cys Leu Lys Cys Asn Leu Cys Leu Ala Met 
        115                 120                 125             


Asn Leu Gln Gly Arg His Lys Cys Ile Glu Asn Val Ser Arg Gln Asn 
    130                 135                 140                 


Cys Pro Ile Cys Leu Glu Asp Ile His Thr Ser Arg Val Val Ala His 
145                 150                 155                 160 


Val Leu Pro Cys Gly His Leu Leu His Arg Thr Cys Tyr Glu Glu Met 
                165                 170                 175     


Leu Lys Glu Tyr Asp Gln Val Leu Glu Thr Ala Gly 
            180                 185             

<210>  1928
<211>  998
<212>  DNA
<213>  Homo sapiens

<400>  1928
tccggttccc ggggctacga ggcggaagcg aaggcagacg cagtctccgt cgttgacgtt     60

agtcgcagtc ttcgctgcta acgttttgtt atgagttgct aaaatggtga aatgctgctc    120

cgccattgga tgtgcttctc gctgcttgcc aaattcgaag ttaaaaggac tgacatttca    180

cgtattcccc acagatgaaa acatcaaaag gaaatgggta ttagcaatga aaagacttga    240

tgtgaatgca gccggcattt gggagcctaa aaaaggagat gtgttgtgtt cgaggcactt    300

taagaagaca gattttgaca gaagtgctcc aaatattaaa ctgaaacctg gagtcatacc    360

ttctatcttt gattctccat atcacctaca ggtttgttta tgagatactg tttaccatca    420

ttgctcactt tttttttttt ttttttttga gatagagtct cgctctgtca ccaaggctgg    480

agtgcagtgg cgcgatctca gctcactgca atctctgcct ccagggttta agcaattctc    540

tgcctcagcc tcccgagaag ctgggattac aggcacctgc caccacacct ggctaatttt    600

tgtattttta ggagagatgg cgtttcacca tcttggccag gctggtcttg aactcctgac    660

ctcgtgatcc accctcctcg gcgtcccaaa gtgctgggat tacaggcatg agccaccgtg    720

cctggccatt gctcactttt tatgatacta ttgaagaacc ttcaccactc ttgctaacat    780

ttttattgtt tgcttattca tttgaagtct gttcttgaag ttttaaattt gtagactgca    840

tcttcaactt ttgtaatgtg tagtaggagt attttaccag taaccactca taaatatttg    900

tatattacta aggtttgatg aagtgggctg actttaggaa ttagcataac tgaagatttt    960

tgtctaaaaa tggaagttaa cgtaagaagg ttgaactg                            998


<210>  1929
<211>  99
<212>  PRT
<213>  Homo sapiens

<400>  1929


Met Val Lys Cys Cys Ser Ala Ile Gly Cys Ala Ser Arg Cys Leu Pro 
1               5                   10                  15      


Asn Ser Lys Leu Lys Gly Leu Thr Phe His Val Phe Pro Thr Asp Glu 
            20                  25                  30          


Asn Ile Lys Arg Lys Trp Val Leu Ala Met Lys Arg Leu Asp Val Asn 
        35                  40                  45              


Ala Ala Gly Ile Trp Glu Pro Lys Lys Gly Asp Val Leu Cys Ser Arg 
    50                  55                  60                  


His Phe Lys Lys Thr Asp Phe Asp Arg Ser Ala Pro Asn Ile Lys Leu 
65                  70                  75                  80  


Lys Pro Gly Val Ile Pro Ser Ile Phe Asp Ser Pro Tyr His Leu Gln 
                85                  90                  95      


Val Cys Leu 
            

<210>  1930
<211>  1151
<212>  DNA
<213>  Homo sapiens

<400>  1930
tcccggggct acgaggcgga agcgaaggca gacgcagtct ccgtcgttga cgttagtcgc     60

agtcttcgct gctaacgatt ccccacagat gaaaacatca aaaggaaatg ggtattagca    120

atgaaaagac ttgatgtgaa tgcagccggc atttgggagc ctaaaaaagg agatgtgttg    180

tgttcgaggc actttaagaa gacagatttt gacagaagtg ctccaaatat taaactgaaa    240

cctggagtca taccttctat ctttgattct ccatatcacc tacagatatc catgttcaag    300

aggaaatgtt tgttcaaggc aaaaaattat ttctcagtaa ccatcatagc taacatttat    360

aaggtgccaa tctttattca aagcacttaa actttattaa ctcatttaac ttcacaacaa    420

ccctataaga gacagagtct cactccatca cccaggctgg agtgcagtgg cgcaatctcg    480

gctcatcact ccgtcgccca ggctggaatg cagtggcgca atctcggctc actacaacct    540

ctgcctccca agttcaagtg attctcatgc ttcagcctcc tgatcagctg ggactacagg    600

agtgcaccac catgcccagc taatttttgt attttttggt agagacggag tttcaccatg    660

ttggccaggc tggtctcaaa cttctggctt caagtgatac cccccaacct cggcctccca    720

aagtgctaga attacaggtg tgagtcccca ccaccacatc tggcctagga ctctgttttt    780

ttttttagac aaagggtgtg agcaggagaa aaaagaagag atgagattgc cctgagccca    840

aatccagaaa gcagggcaca accaagagag ctaaagaccc ctgggtaaag ccacctcctg    900

cccccaagtc cttccctgac gcagacttgc tggacaacca ggtgcgtcaa catgcaggta    960

caggggcaga cccttctccc ttccctcctc ctccatgcct ttcacaacta tttgctgagt   1020

gtcactgtgc caagccctgg ggctaaaact aatcaagatt tggttcttct gtacacttaa   1080

aagtggttaa aatggtcaat tttatgttac gtatatttta ccacaattta aaataaattt   1140

gaaaaaaaat t                                                        1151


<210>  1931
<211>  89
<212>  PRT
<213>  Homo sapiens

<400>  1931


Met Lys Arg Leu Asp Val Asn Ala Ala Gly Ile Trp Glu Pro Lys Lys 
1               5                   10                  15      


Gly Asp Val Leu Cys Ser Arg His Phe Lys Lys Thr Asp Phe Asp Arg 
            20                  25                  30          


Ser Ala Pro Asn Ile Lys Leu Lys Pro Gly Val Ile Pro Ser Ile Phe 
        35                  40                  45              


Asp Ser Pro Tyr His Leu Gln Ile Ser Met Phe Lys Arg Lys Cys Leu 
    50                  55                  60                  


Phe Lys Ala Lys Asn Tyr Phe Ser Val Thr Ile Ile Ala Asn Ile Tyr 
65                  70                  75                  80  


Lys Val Pro Ile Phe Ile Gln Ser Thr 
                85                  

<210>  1932
<211>  573
<212>  DNA
<213>  Homo sapiens

<400>  1932
ggaagcgaag gcagacgcag tctccgtcgt tgacgttagt cgcagtcttc gctgctaacg     60

attccccaca gatgaaaaca tcaaaaggaa atgggtatta gcaatgaaaa gacttgatgt    120

gaatgcagcc ggcatttggg agcctaaaaa aggagatgtg ttgtgttcga ggcactttaa    180

gaagacagat tttgacagaa gtgctccaaa tattaaactg aaacctggag tcataccttc    240

tatctttgat tctccatatc acctacaggg gaaaagagaa aaacttcatt gtagaaaaaa    300

cttcaccctc aaaaccgttc cagccactaa ctacaatcac catcttgttg gtgcttcctc    360

atgtattgaa gaattccaat cccagttcat ttttaaacac aggaaaagga aacaagaaca    420

ggaagaagaa caaaaaccaa gaagagagaa atgcatttca tagggaatgg caagtggaca    480

ggcaacagtg gtcagatatc catgttcaag aggaaatgtt tgttcaaggc aaaaaattat    540

ttctcagtaa ccatcatagc taacatttat aag                                 573


<210>  1933
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  1933


Met Lys Arg Leu Asp Val Asn Ala Ala Gly Ile Trp Glu Pro Lys Lys 
1               5                   10                  15      


Gly Asp Val Leu Cys Ser Arg His Phe Lys Lys Thr Asp Phe Asp Arg 
            20                  25                  30          


Ser Ala Pro Asn Ile Lys Leu Lys Pro Gly Val Ile Pro Ser Ile Phe 
        35                  40                  45              


Asp Ser Pro Tyr His Leu Gln Gly Lys Arg Glu Lys Leu His Cys Arg 
    50                  55                  60                  


Lys Asn Phe Thr Leu Lys Thr Val Pro Ala Thr Asn Tyr Asn His His 
65                  70                  75                  80  


Leu Val Gly Ala Ser Ser Cys Ile Glu Glu Phe Gln Ser Gln Phe Ile 
                85                  90                  95      


Phe Lys His Arg Lys Arg Lys Gln Glu Gln Glu Glu Glu Gln Lys Pro 
            100                 105                 110         


Arg Arg Glu Lys Cys Ile Ser 
        115                 

<210>  1934
<211>  1115
<212>  DNA
<213>  Homo sapiens

<400>  1934
gaagcgaagg cagacgcagt ctccgtcgtt gacgttagtc gcagtcttcg ctgctaacgt     60

tttgttatga gttgctaaaa tggtgaaatg ctgctccgcc attggatgtg cttctcgctg    120

cttgccaaat tcgaagttaa aaggactgac atttcacgta ttccccacag atgaaaacat    180

caaaaggaaa tgggtattag caatgaaaag acttgatgtg aatgcagccg gcatttggga    240

gcctaaaaaa ggagatatgt tttcaataga gattattttt ccctcaccct atttgtgaat    300

atataaatta aagtaagaca atggagtaag taagagggta gatccaaaca cagtatgtct    360

aaattctagc actctactgg ctgcttagaa tacaccaaac ctggaagacc tttccaagag    420

taaaatccca gtctgccact atcaaaattg ccacagtcac ttttactact tgtgttcata    480

gtagactcag cacttctttt tcactggacc tagtataact gagaaataaa taactgtgtg    540

caaaatattg gtatcattaa ggacccagag ctgcccattt tctctttgtt ctaataggga    600

agcaattact gatagaaatg tgagattaaa aatagggtcc tccctgctgc tccaaacaaa    660

tgcctaaaca cagtatgtat ctcagtcctc tgttcccaga gattccaccc tagcccagga    720

aagaactggc ctgtgtaaag caaaacccaa gtcatccccc tccagaaatt tctctggcag    780

ccaagcctga ccctaagggt tccactttgc tttaaaagct aggagtggcc tctagagcca    840

ggaacacatt aatacaacag ttcaacctca gcaccaagtc aggtacgaag cgcttgatac    900

gtggaatttt tctctatatc aagtttaaat ttctggaaat agactttggt tgctaatgac    960

aattacagtt ataccatagt ctgtaatttg agaaaaggtg aaatgtattt aatatatatt   1020

tagttttaat aaaaagataa aattattaca gaaataattg agagagagaa aatctattat   1080

aatttatttg aaaaataaaa cattttatcc agtaa                              1115


<210>  1935
<211>  72
<212>  PRT
<213>  Homo sapiens

<400>  1935


Met Val Lys Cys Cys Ser Ala Ile Gly Cys Ala Ser Arg Cys Leu Pro 
1               5                   10                  15      


Asn Ser Lys Leu Lys Gly Leu Thr Phe His Val Phe Pro Thr Asp Glu 
            20                  25                  30          


Asn Ile Lys Arg Lys Trp Val Leu Ala Met Lys Arg Leu Asp Val Asn 
        35                  40                  45              


Ala Ala Gly Ile Trp Glu Pro Lys Lys Gly Asp Met Phe Ser Ile Glu 
    50                  55                  60                  


Ile Ile Phe Pro Ser Pro Tyr Leu 
65                  70          

<210>  1936
<211>  973
<212>  DNA
<213>  Homo sapiens

<400>  1936
agcgaaggca gacgcagtct ccgtcgttga cgttagtcgc agtcttcgct gctaacgttt     60

tgttatgagt tgctaaaatg gtgaaatgct gctccgccat tggatgtgct tctcgctgct    120

tgccaaattc gaagttaaaa ggactgacat ttcacgtatt ccccacagat gaaaacatca    180

aaaggaaatg ggtattagca atgaaaagac ttgatgtgaa tgcagccggc atttgggagc    240

ctaaaaaagg agatgtgttg tgttcgaggc actttaagaa gacagatttt gacagaagtg    300

ctccaaatat taaactgaaa cctggagtca taccttctat ctttgattct ccatatcacc    360

tacaggggaa aagagaaaaa cttcattgta gaaaaaactt caccctcaaa accgttccag    420

ccactaacta caatcaccat cttgttggtg cttcctcatg tattgaagaa ttccaatccc    480

agttcatttt tgtaagtaaa ttacttgctg agctcatgtt aattctttta agatgaatat    540

gtcctctcca ttacaatcaa atttttcaga atcctagcaa aatctagggg ttaatatgta    600

atatctacaa ataatattgc ttcctagagt cattgtaatt tatatatatg caacagcaaa    660

atagaggtag ttaatccttt ggttacatat gtagttcact gaagaaggct tttgcaagga    720

tatttctacc aaggaaataa ttcttccctc taactgctat aatttccgta tgaaatatgt    780

aataaaaaat agctatttaa gttttctcag tcatacacat acagagtatt caagcttgca    840

tttatttatt catctcattg cttattcatg ttagaggcag gcatggaatc tagatctctt    900

ttactatctt gattaataca ggtttataat aattttttct atttttgtgg gtacatagta    960

ggtatgtata ttt                                                       973


<210>  1937
<211>  152
<212>  PRT
<213>  Homo sapiens

<400>  1937


Met Val Lys Cys Cys Ser Ala Ile Gly Cys Ala Ser Arg Cys Leu Pro 
1               5                   10                  15      


Asn Ser Lys Leu Lys Gly Leu Thr Phe His Val Phe Pro Thr Asp Glu 
            20                  25                  30          


Asn Ile Lys Arg Lys Trp Val Leu Ala Met Lys Arg Leu Asp Val Asn 
        35                  40                  45              


Ala Ala Gly Ile Trp Glu Pro Lys Lys Gly Asp Val Leu Cys Ser Arg 
    50                  55                  60                  


His Phe Lys Lys Thr Asp Phe Asp Arg Ser Ala Pro Asn Ile Lys Leu 
65                  70                  75                  80  


Lys Pro Gly Val Ile Pro Ser Ile Phe Asp Ser Pro Tyr His Leu Gln 
                85                  90                  95      


Gly Lys Arg Glu Lys Leu His Cys Arg Lys Asn Phe Thr Leu Lys Thr 
            100                 105                 110         


Val Pro Ala Thr Asn Tyr Asn His His Leu Val Gly Ala Ser Ser Cys 
        115                 120                 125             


Ile Glu Glu Phe Gln Ser Gln Phe Ile Phe Val Ser Lys Leu Leu Ala 
    130                 135                 140                 


Glu Leu Met Leu Ile Leu Leu Arg 
145                 150         

<210>  1938
<211>  3558
<212>  DNA
<213>  Homo sapiens

<400>  1938
agcgaaggca gacgcagtct ccgtcgttga cgttagtcgc agtcttcgct gctaacgttt     60

tgttatgagt tgctaaaatg gtgaaatgct gctccgccat tggatgtgct tctcgctgct    120

tgccaaattc gaagttaaaa ggactgacat ttcacgtatt ccccacagat gaaaacatca    180

aaaggaaatg ggtattagca atgaaaagac ttgatgtgaa tgcagccggc atttgggagc    240

ctaaaaaagg agatgtgttg tgttcgaggc actttaagaa gacagatttt gacagaagtg    300

ctccaaatat taaactgaaa cctggagtca taccttctat ctttgattct ccatatcacc    360

tacaggggaa aagagaaaaa cttcattgta gaaaaaactt caccctcaaa accgttccag    420

ccactaacta caatcaccat cttgttggtg cttcctcatg tattgaagaa ttccaatccc    480

agttcatttt tgaacatagc tacagtgtaa tggacagtcc aaagaaactt aagcataaat    540

tagatcatgt gatcggcgag ctagaggata caaaggaaag tctacggaat gttttagacc    600

gagaaaaacg ttttcagaaa tcattgagga agacaatcag ggaattaaag gatgaatgtc    660

tgatcagcca agaaacagca aatagactgg acactttctg ttgggactgt tgtcaggaga    720

gcatagaaca ggactatatt tcatgaaata atttcatgtt acgttccacc taaaattgtc    780

attggtacaa atttttataa aatctcattt accatcacta aataatatcc atcatttaaa    840

gtgctgcttt ggattctctg gagcattatg cattatagtt gttatccaaa gacttttttg    900

aaaatatgca gaaatttgtg gtaattatgt atttgtgtct tgtgacaatt atgttttata    960

gacctacact agtgccaggt cactattgta agatgttaaa atctcaagaa aatttcacag   1020

agctaaagaa atgatgtcaa attagtcaca ttaagctata gtagaaggaa ttggacactt   1080

ctccagatat ttggcttcaa aggagtacct ttacttacat gtgctttatg gtaagtacat   1140

tgaattttac tttaaatgca ttttactaca aagcacaatt catttgtaat gcatatccat   1200

cttggattca atccaaggtg ctttagctat cagtagtacc aaaggatctt tttacaaggc   1260

ttcctgtggt attgactctg agaataacac atagtgaaga tctgtgggct tttaaaattg   1320

ttcacagcca atttaagaag acccctcatg aagtctcagt tttcagtaca gtacatcatt   1380

cctcctcact aggagcactt tgatgtaaac cagaatagct ttaaaaagac aaaaaggatc   1440

gtagatctga tttttaaatg gttggttgct ctgacagatc tgaacacttt gcttcatgac   1500

tatttcgtca taaaggtata tgtttaaaat ctgaatggca gtactagctc tatactttta   1560

atactgcttt gtattttata tgtaaagtag tattgctgac attttaaaaa aatacaaaat   1620

acaaaagaaa ccattagaaa ttaataactg tggctcttcc agttgaaata ggaattggag   1680

agaaaggatt agaatatttt aattagggga gtagattatt gtccaaaggc ttttatttag   1740

agaaacgggt aattaaaaca gcagctttag aatagcttct tactgaatat gcaaaagaat   1800

aattccttgt tatttcctaa ttgatccaag tctcataaat ttagcttttg tcataattcc   1860

ttaccgaaaa caactgaaat tgagagtcat aaatactgtg ggttagaata aaaaccattt   1920

gccaaagcaa cactctactt agaagcacat gtacatacat ggacctcatt cagaagtcca   1980

tgttgtagca gttagaattt gagtatcagc catttcattg tagtaacaaa aattgaattg   2040

cattttgtgc tcagttgttt attgtaattt tatttttgtt acattaatat tagttaagat   2100

atggtcactt gaattttttg tatttaagaa ttttctgttt taatgcatgt tatactttta   2160

tgtaggattc caaaccttcc ctctaaatgg gatttaaccc acatctgcga gatcagcgtt   2220

atgctaagag gaaatcactg aggccatatc tttttacaat ctgaaaaaaa agtagtaaaa   2280

aggtagttaa aaaaaaaaaa ggccgggtgg tggctcatac ctgtaatcct agcactttgg   2340

gaggccaagg caggcagatc acttgaggtc aggggttcaa aaccagcctg gccaagatgg   2400

tgaaacccca tctctgctaa aaatacaaaa aaaaattagc cgggcatggt ggcacgtgcc   2460

tgtaatccca gctacttggg agactgaggc aggagaattg cttgaacccg ggaggcggag   2520

attgcagtga gccaagatca cgccgttgca ctccagcctg agcaacagag caagactcca   2580

tctcaaaaaa acaaaactac tttcattaat tacccattat ttattttagt tacttaattt   2640

tgagttcata aatggccacc ctaatggaaa gtttgggtat gatcttaggt tttatggaga   2700

tgttttcaat agagattatt tttccctcac cctatttgtg aatatataaa ttaaagtaag   2760

acaatggagt aagtaagagg gtagatccaa acacagtatg tctaaattct agcactctac   2820

tggctgctta gaatacacca aacctggaag acctttccaa gagtaaaatc ccagtctgcc   2880

actatcaaaa ttgccacagt cacttttact acttgtgttc atagtagact cagcacttct   2940

ttttcactgg acctagtata actgagaaat aaataactgt gtgcaaaata ttggtatcat   3000

taaggaccca gagctgccca ttttctcttt gttctaatag ggaagcaatt actgatagaa   3060

atgtgagatt aaaaataggg tcctccctgc tgctccaaac aaatgcctaa acacagtatg   3120

tatctcagtc ctctgttccc agagattcca ccctagccca ggaaagaact ggcctgtgta   3180

aagcaaaacc caagtcatcc ccctccagaa atttctctgg cagccaagcc tgaccctaag   3240

ggttccactt tgctttaaaa gctaggagtg gcctctagag ccaggaacac attaatacaa   3300

cagttcaacc tcagcaccaa gtcaggtacg aagcgcttga tacgtggaat ttttctctat   3360

atcaagttta aatttctgga aatagacttt ggttgctaat gacaattaca gttataccat   3420

agtctgtaat ttgagaaaag gtgaaatgta tttaatatat atttagtttt aataaaaaga   3480

taaaattatt acagaaataa ttgagagaga gaaaatctat tataatttat ttgaaaaata   3540

aaacatttta tccagtaa                                                 3558


<210>  1939
<211>  222
<212>  PRT
<213>  Homo sapiens

<400>  1939


Met Val Lys Cys Cys Ser Ala Ile Gly Cys Ala Ser Arg Cys Leu Pro 
1               5                   10                  15      


Asn Ser Lys Leu Lys Gly Leu Thr Phe His Val Phe Pro Thr Asp Glu 
            20                  25                  30          


Asn Ile Lys Arg Lys Trp Val Leu Ala Met Lys Arg Leu Asp Val Asn 
        35                  40                  45              


Ala Ala Gly Ile Trp Glu Pro Lys Lys Gly Asp Val Leu Cys Ser Arg 
    50                  55                  60                  


His Phe Lys Lys Thr Asp Phe Asp Arg Ser Ala Pro Asn Ile Lys Leu 
65                  70                  75                  80  


Lys Pro Gly Val Ile Pro Ser Ile Phe Asp Ser Pro Tyr His Leu Gln 
                85                  90                  95      


Gly Lys Arg Glu Lys Leu His Cys Arg Lys Asn Phe Thr Leu Lys Thr 
            100                 105                 110         


Val Pro Ala Thr Asn Tyr Asn His His Leu Val Gly Ala Ser Ser Cys 
        115                 120                 125             


Ile Glu Glu Phe Gln Ser Gln Phe Ile Phe Glu His Ser Tyr Ser Val 
    130                 135                 140                 


Met Asp Ser Pro Lys Lys Leu Lys His Lys Leu Asp His Val Ile Gly 
145                 150                 155                 160 


Glu Leu Glu Asp Thr Lys Glu Ser Leu Arg Asn Val Leu Asp Arg Glu 
                165                 170                 175     


Lys Arg Phe Gln Lys Ser Leu Arg Lys Thr Ile Arg Glu Leu Lys Asp 
            180                 185                 190         


Glu Cys Leu Ile Ser Gln Glu Thr Ala Asn Arg Leu Asp Thr Phe Cys 
        195                 200                 205             


Trp Asp Cys Cys Gln Glu Ser Ile Glu Gln Asp Tyr Ile Ser 
    210                 215                 220         

<210>  1940
<211>  3432
<212>  DNA
<213>  Homo sapiens

<400>  1940
agcgaaggca gacgcagtct ccgtcgttga cgttagtcgc agtcttcgct gctaacgttt     60

tgttatgagt tgctaaaatg gtgaaatgct gctccgccat tggatgtgct tctcgctgct    120

tgccaaattc gaagttaaaa ggactgacat ttcacgtatt ccccacagat gaaaacatca    180

aaaggaaatg ggtattagca atgaaaagac ttgatgtgaa tgcagccggc atttgggagc    240

ctaaaaaagg agatgtgttg tgttcgaggc actttaagaa gacagatttt gacagaagtg    300

ctccaaatat taaactgaaa cctggagtca taccttctat ctttgattct ccatatcacc    360

tacaggaaca tagctacagt gtaatggaca gtccaaagaa acttaagcat aaattagatc    420

atgtgatcgg cgagctagag gatacaaagg aaagtctacg gaatgtttta gaccgagaaa    480

aacgttttca gaaatcattg aggaagacaa tcagggaatt aaaggatgaa tgtctgatca    540

gccaagaaac agcaaataga ctggacactt tctgttggga ctgttgtcag gagagcatag    600

aacaggacta tatttcatga aataatttca tgttacgttc cacctaaaat tgtcattggt    660

acaaattttt ataaaatctc atttaccatc actaaataat atccatcatt taaagtgctg    720

ctttggattc tctggagcat tatgcattat agttgttatc caaagacttt tttgaaaata    780

tgcagaaatt tgtggtaatt atgtatttgt gtcttgtgac aattatgttt tatagaccta    840

cactagtgcc aggtcactat tgtaagatgt taaaatctca agaaaatttc acagagctaa    900

agaaatgatg tcaaattagt cacattaagc tatagtagaa ggaattggac acttctccag    960

atatttggct tcaaaggagt acctttactt acatgtgctt tatggtaagt acattgaatt   1020

ttactttaaa tgcattttac tacaaagcac aattcatttg taatgcatat ccatcttgga   1080

ttcaatccaa ggtgctttag ctatcagtag taccaaagga tctttttaca aggcttcctg   1140

tggtattgac tctgagaata acacatagtg aagatctgtg ggcttttaaa attgttcaca   1200

gccaatttaa gaagacccct catgaagtct cagttttcag tacagtacat cattcctcct   1260

cactaggagc actttgatgt aaaccagaat agctttaaaa agacaaaaag gatcgtagat   1320

ctgattttta aatggttggt tgctctgaca gatctgaaca ctttgcttca tgactatttc   1380

gtcataaagg tatatgttta aaatctgaat ggcagtacta gctctatact tttaatactg   1440

ctttgtattt tatatgtaaa gtagtattgc tgacatttta aaaaaataca aaatacaaaa   1500

gaaaccatta gaaattaata actgtggctc ttccagttga aataggaatt ggagagaaag   1560

gattagaata ttttaattag gggagtagat tattgtccaa aggcttttat ttagagaaac   1620

gggtaattaa aacagcagct ttagaatagc ttcttactga atatgcaaaa gaataattcc   1680

ttgttatttc ctaattgatc caagtctcat aaatttagct tttgtcataa ttccttaccg   1740

aaaacaactg aaattgagag tcataaatac tgtgggttag aataaaaacc atttgccaaa   1800

gcaacactct acttagaagc acatgtacat acatggacct cattcagaag tccatgttgt   1860

agcagttaga atttgagtat cagccatttc attgtagtaa caaaaattga attgcatttt   1920

gtgctcagtt gtttattgta attttatttt tgttacatta atattagtta agatatggtc   1980

acttgaattt tttgtattta agaattttct gttttaatgc atgttatact tttatgtagg   2040

attccaaacc ttccctctaa atgggattta acccacatct gcgagatcag cgttatgcta   2100

agaggaaatc actgaggcca tatcttttta caatctgaaa aaaaagtagt aaaaaggtag   2160

ttaaaaaaaa aaaaggccgg gtggtggctc atacctgtaa tcctagcact ttgggaggcc   2220

aaggcaggca gatcacttga ggtcaggggt tcaaaaccag cctggccaag atggtgaaac   2280

cccatctctg ctaaaaatac aaaaaaaaat tagccgggca tggtggcacg tgcctgtaat   2340

cccagctact tgggagactg aggcaggaga attgcttgaa cccgggaggc ggagattgca   2400

gtgagccaag atcacgccgt tgcactccag cctgagcaac agagcaagac tccatctcaa   2460

aaaaacaaaa ctactttcat taattaccca ttatttattt tagttactta attttgagtt   2520

cataaatggc caccctaatg gaaagtttgg gtatgatctt aggttttatg gagatgtttt   2580

caatagagat tatttttccc tcaccctatt tgtgaatata taaattaaag taagacaatg   2640

gagtaagtaa gagggtagat ccaaacacag tatgtctaaa ttctagcact ctactggctg   2700

cttagaatac accaaacctg gaagaccttt ccaagagtaa aatcccagtc tgccactatc   2760

aaaattgcca cagtcacttt tactacttgt gttcatagta gactcagcac ttctttttca   2820

ctggacctag tataactgag aaataaataa ctgtgtgcaa aatattggta tcattaagga   2880

cccagagctg cccattttct ctttgttcta atagggaagc aattactgat agaaatgtga   2940

gattaaaaat agggtcctcc ctgctgctcc aaacaaatgc ctaaacacag tatgtatctc   3000

agtcctctgt tcccagagat tccaccctag cccaggaaag aactggcctg tgtaaagcaa   3060

aacccaagtc atccccctcc agaaatttct ctggcagcca agcctgaccc taagggttcc   3120

actttgcttt aaaagctagg agtggcctct agagccagga acacattaat acaacagttc   3180

aacctcagca ccaagtcagg tacgaagcgc ttgatacgtg gaatttttct ctatatcaag   3240

tttaaatttc tggaaataga ctttggttgc taatgacaat tacagttata ccatagtctg   3300

taatttgaga aaaggtgaaa tgtatttaat atatatttag ttttaataaa aagataaaat   3360

tattacagaa ataattgaga gagagaaaat ctattataat ttatttgaaa aataaaacat   3420

tttatccagt aa                                                       3432


<210>  1941
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  1941


Met Val Lys Cys Cys Ser Ala Ile Gly Cys Ala Ser Arg Cys Leu Pro 
1               5                   10                  15      


Asn Ser Lys Leu Lys Gly Leu Thr Phe His Val Phe Pro Thr Asp Glu 
            20                  25                  30          


Asn Ile Lys Arg Lys Trp Val Leu Ala Met Lys Arg Leu Asp Val Asn 
        35                  40                  45              


Ala Ala Gly Ile Trp Glu Pro Lys Lys Gly Asp Val Leu Cys Ser Arg 
    50                  55                  60                  


His Phe Lys Lys Thr Asp Phe Asp Arg Ser Ala Pro Asn Ile Lys Leu 
65                  70                  75                  80  


Lys Pro Gly Val Ile Pro Ser Ile Phe Asp Ser Pro Tyr His Leu Gln 
                85                  90                  95      


Glu His Ser Tyr Ser Val Met Asp Ser Pro Lys Lys Leu Lys His Lys 
            100                 105                 110         


Leu Asp His Val Ile Gly Glu Leu Glu Asp Thr Lys Glu Ser Leu Arg 
        115                 120                 125             


Asn Val Leu Asp Arg Glu Lys Arg Phe Gln Lys Ser Leu Arg Lys Thr 
    130                 135                 140                 


Ile Arg Glu Leu Lys Asp Glu Cys Leu Ile Ser Gln Glu Thr Ala Asn 
145                 150                 155                 160 


Arg Leu Asp Thr Phe Cys Trp Asp Cys Cys Gln Glu Ser Ile Glu Gln 
                165                 170                 175     


Asp Tyr Ile Ser 
            180 

<210>  1942
<211>  868
<212>  DNA
<213>  Homo sapiens

<400>  1942
aggcagacgc agtctccgtc gttgacgtta gtcgcagtct tcgctgctaa cgattcccca     60

cagatgaaaa catcaaaagg aaatgggtat tagcaatgaa aagacttgat gtgaatgcag    120

ccggcatttg ggagcctaaa aaaggagatg tgttgtgttc gaggcacttt aagaagacag    180

attttgacag aagtgctcca aatattaaac tgaaacctgg agtcatacct tctatctttg    240

attctccata tcacctacag gggaaaagag aaaaacttca ttgtagaaaa aacttcaccc    300

tcaaaaccgt tccagccact aactacaatc accatcttgt tggtgcttcc tcatgtattg    360

aagaattcca atcccagttc atttttgtaa gtaaattact tgctgagctc atgttaattc    420

ttttaagatg aatatgtcct ctccattaca atcaaatttt tcagaatcct agcaaaatct    480

aggggttaat atgtaatatc tacaaataat attgcttcct agagtcattg taatttatat    540

atatgcaaca gcaaaataga ggtagttaat cctttggtta catatgtagt tcactgaaga    600

aggcttttgc aaggatattt ctaccaagga aataattctt ccctctaact gctataattt    660

ccgtatgaaa tatgtaataa aaaatagcta tttaagtttt ctcagtcata cacatacaga    720

gtattcaagc ttgcatttat ttattcatct cattgcttat tcatgttaga ggcaggcatg    780

gaatctagat ctcttttact atcttgatta atacaggttt ataataattt tttctatttt    840

tgtgggtaca tagtaggtat gtatattt                                       868


<210>  1943
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  1943


Met Lys Arg Leu Asp Val Asn Ala Ala Gly Ile Trp Glu Pro Lys Lys 
1               5                   10                  15      


Gly Asp Val Leu Cys Ser Arg His Phe Lys Lys Thr Asp Phe Asp Arg 
            20                  25                  30          


Ser Ala Pro Asn Ile Lys Leu Lys Pro Gly Val Ile Pro Ser Ile Phe 
        35                  40                  45              


Asp Ser Pro Tyr His Leu Gln Gly Lys Arg Glu Lys Leu His Cys Arg 
    50                  55                  60                  


Lys Asn Phe Thr Leu Lys Thr Val Pro Ala Thr Asn Tyr Asn His His 
65                  70                  75                  80  


Leu Val Gly Ala Ser Ser Cys Ile Glu Glu Phe Gln Ser Gln Phe Ile 
                85                  90                  95      


Phe Val Ser Lys Leu Leu Ala Glu Leu Met Leu Ile Leu Leu Arg 
            100                 105                 110     

<210>  1944
<211>  600
<212>  DNA
<213>  Homo sapiens

<400>  1944
agacgcagtc tccgtcgttg acgttagtcg cagtcttcgc tgctaacgat tccccacaga     60

tgaaaacatc aaaaggaaat gggtattagc aatgaaaaga cttgatgtga atgcagccgg    120

catttgggag cctaaaaaag gagatgtgtt gtgttcgagg cactttaaga agacagattt    180

tgacagaagt gctccaaata ttaaactgaa acctggagtc ataccttcta tctttgattc    240

tccatatcac ctacagaaac acaggaaaag gaaacaagaa caggaagaag aacaaaaacc    300

aagaagagag aaatgcattt catagggaat ggcaagtgga caggcaacag tggtcagata    360

tccatgttca agaggaaatg tttgttcaag gcaaaaaatt atttctcagt aaccatcata    420

gctaacattt ataaggtgcc aatctttatt caaagcactt aaactttatt aactcattta    480

acttcacaac aaccctataa ggtaggtact attattatta ttctcatttt acagaagagg    540

aaattaaaca gagaaaagct aggtaatttg cccaaggttt cacagctggt ataacgatgt    600


<210>  1945
<211>  77
<212>  PRT
<213>  Homo sapiens

<400>  1945


Met Lys Arg Leu Asp Val Asn Ala Ala Gly Ile Trp Glu Pro Lys Lys 
1               5                   10                  15      


Gly Asp Val Leu Cys Ser Arg His Phe Lys Lys Thr Asp Phe Asp Arg 
            20                  25                  30          


Ser Ala Pro Asn Ile Lys Leu Lys Pro Gly Val Ile Pro Ser Ile Phe 
        35                  40                  45              


Asp Ser Pro Tyr His Leu Gln Lys His Arg Lys Arg Lys Gln Glu Gln 
    50                  55                  60                  


Glu Glu Glu Gln Lys Pro Arg Arg Glu Lys Cys Ile Ser 
65                  70                  75          

<210>  1946
<211>  576
<212>  DNA
<213>  Homo sapiens

<400>  1946
agacgcagtc tccgtcgttg acgttagtcg cagtcttcgc tgctaacgat tccccacaga     60

tgaaaacatc aaaaggaaat gggtattagc aatgaaaaga cttgatgtga atgcagccgg    120

catttgggag cctaaaaaag gagatgtgtt gtgttcgagg cactttaaga agacagattt    180

tgacagaagt gctccaaata ttaaactgaa acctggagtc ataccttcta tctttgattc    240

tccatatcac ctacagaaac acaggaaaag gaaacaagaa caggaagaag aacaaaaacc    300

aagaagagag aaatgcattt catagggaat ggcaagtgga caggcaacag tggtcagata    360

tccatgttca agaggaaatg tttgttcaag gcaaaaaatt atttctcagt aaccatcata    420

gctaacattt ataaggtgcc aatctttatt caaagcactt aaactttatt aactcattta    480

acttcacaac aaccctataa gagacagagt ctcactccat cacccaggct ggagtgcagt    540

ggcgcaatct cggctcatca ctccgtcgcc caggct                              576


<210>  1947
<211>  77
<212>  PRT
<213>  Homo sapiens

<400>  1947


Met Lys Arg Leu Asp Val Asn Ala Ala Gly Ile Trp Glu Pro Lys Lys 
1               5                   10                  15      


Gly Asp Val Leu Cys Ser Arg His Phe Lys Lys Thr Asp Phe Asp Arg 
            20                  25                  30          


Ser Ala Pro Asn Ile Lys Leu Lys Pro Gly Val Ile Pro Ser Ile Phe 
        35                  40                  45              


Asp Ser Pro Tyr His Leu Gln Lys His Arg Lys Arg Lys Gln Glu Gln 
    50                  55                  60                  


Glu Glu Glu Gln Lys Pro Arg Arg Glu Lys Cys Ile Ser 
65                  70                  75          

<210>  1948
<211>  582
<212>  DNA
<213>  Homo sapiens

<400>  1948
agtctccgtc gttgacgtta gtcgcagtct tcgctgctaa cgattcccca cagatgaaaa     60

catcaaaagg aaatgggtat tagcaatgaa aagacttgat gtgaatgcag ccggcatttg    120

ggagcctaaa aaaggagatg tgttgtgttc gaggcacttt aagaagacag attttgacag    180

aagtgctcca aatattaaac tgaaacctgg agtcatacct tctatctttg attctccata    240

tcacctacag atatccatgt tcaagaggaa atgtttgttc aaggcaaaaa attatttctc    300

agtaaccatc atagctaaca tttataaggg tcttactctg tcacccaggc tgatgtgcag    360

tggtaccatc agctcactgt agcctcgacc tcccaggctc aagtgatcct tccacctcag    420

cctcccaagt agctggaact acaggtgact tagatacaga cactgaacag acaaaccaat    480

gaataattcc gtcttggttg acaattggtt gggacaagtt cacatgccaa gatgtcactg    540

aaccacaaga tcctacagtc actgacaact atttcctaac at                       582


<210>  1949
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  1949


Met Lys Arg Leu Asp Val Asn Ala Ala Gly Ile Trp Glu Pro Lys Lys 
1               5                   10                  15      


Gly Asp Val Leu Cys Ser Arg His Phe Lys Lys Thr Asp Phe Asp Arg 
            20                  25                  30          


Ser Ala Pro Asn Ile Lys Leu Lys Pro Gly Val Ile Pro Ser Ile Phe 
        35                  40                  45              


Asp Ser Pro Tyr His Leu Gln Ile Ser Met Phe Lys Arg Lys Cys Leu 
    50                  55                  60                  


Phe Lys Ala Lys Asn Tyr Phe Ser Val Thr Ile Ile Ala Asn Ile Tyr 
65                  70                  75                  80  


Lys Gly Leu Thr Leu Ser Pro Arg Leu Met Cys Ser Gly Thr Ile Ser 
                85                  90                  95      


Ser Leu 
        

<210>  1950
<211>  2760
<212>  DNA
<213>  Homo sapiens

<400>  1950
aattataata acagcattct acaaatttaa atcaaaacca gccgggcaca gtggctcatg     60

cctgtaatcc agcactttgg gaggccgagg caggtggatc acttgaggtc aggagttcaa    120

gaccagcctg gccaacatgg caagacctcg tctctactaa aaatacaaac attagctggg    180

catggtagca ggcacctgta atcacagcta ctcaggaggc tgaggcagga gaatcgcttg    240

agcgcagagg ggcggaggtt tcagtgagcc aagattgcac cactgtactc cagcctgggc    300

aacagagcaa gactgtctcc aaaaaaaaaa aaaaagaaaa tcaaaaccat ttcatctctg    360

aaaaatgagg tattacttgt tatcattacc ttcatcatcc ccctgggaca ttggctaaag    420

ttggatgtaa gtcttgaatt actagtattt cccgtgacac ctacatattt caaagaaatc    480

tcccaaaccc ctgccagccc aactatttga gatttaaaat tacatgactt aatgtatgtc    540

caattcttag aacagtgatg cttaggatat agtaaatgat aacatagatg aggaaattga    600

gaggcaggga agctgactgg tccaaggtcc tgcagctaaa caatggcagg gcagagagca    660

cagcgcggat tcaccccact ggtttaatac tctgtttcaa accatcgatg aatgcaggct    720

cttgttgacg tgggcattac tctgcccctc accgggatgt tactgccatt ctgttgctaa    780

atcaccagga tgaggttagg aaccttctcc aggcctcagg ctcctgctct gcaaactgaa    840

ggaactagag gtgtggttaa ggtgcctgaa ccccctttta ggagaaatcc cagcagaaga    900

tgcctaagca agccttgcag gaagtcatct aggccacctt caagtcagtg ccaaccgcag    960

aatctttaga tcccccaaaa gagcacctgt ccctttgtgg tgcttctgac agagaacccc   1020

aagcagccct agacctccct caacctgact caggggtgcc caccactccc catcctccct   1080

gacacacata atcctggctg aggcagccca aatagcagct tccccggatt actcaccgtg   1140

gctctgtgag aagaatgcct ctcccaggca gcgtccgcag ttgtgaccac agatgggaga   1200

ctagcctaat tggacttacc agcagctcac cttggcttcc tcaaggccca gcagcaggac   1260

agggcctttc tctgagcaga acttgaatga taaaagaagc aggtgaagct gatccagcct   1320

cagacagacc tccagtgggc ccttgagggt gtgagaggca gctctgcggg cccaccctag   1380

aactgcgtgt ggacagctag aaagcctagc ctttctgaca ttgctggcct aagaggtttc   1440

atctttaggg tttttttcct tctcaggctg ctagcttcca tctcacttaa tacagaagga   1500

tggtctcaat ttaagcatct gaaacaaatt acttagcaaa aaccattttc gttgtatcca   1560

aacccagtgt cttcagtttg agctctctga aattccaaac acatgttcaa accaccagga   1620

aagagggaaa gagagactga gaagaggggg actgaagcag ggaagtcact atgagattct   1680

ccccaaaatc ccgatgttca gcctctgggt gaaggacatt ccatcctgag acggagggat   1740

tgctctcttc accagcacct ttctgaagtg tctgtgttag aggcagttca gtgctcacac   1800

agcagcctga aattcttagt cctcccacac atctccagtc aaggagcact gtccatgccc   1860

cttcattgtc cataaacacc caagctctta tttagaagca attgatttct caaatctttt   1920

cctatgtatt tattcactaa acctgtcaag caacacattt aagcatgaca gagaaagaat   1980

atgggcatgt gttaggattc cctagagaaa cagaaccaat agggtgagta tatggagagg   2040

agaggtttag tttaaggaag tacctcatgc agttacggag gctggcaagt ccaaaatcta   2100

cagggtaggc caggcaggct gaagactcag agaagagcct atactgcagt tccagtccaa   2160

aagctgtctg ctgcacagtt ccctcttact cagggaagct cagtctttga ttccattcca   2220

gccttcagtt gatcagatga ggcccaccca cattacagag ggccatccgt ttactcaaag   2280

cccactgatt tcaatataaa cctcatccca aaacaccctc ccagaaacat ccagaataat   2340

gtttgaccaa ctatctgggt actaaagccc agccaagttg gcacatcaaa ttaatcattg   2400

cagggtgtga gcaggagaaa aaagaagaga tgagattgcc ctgagcccaa atccagaaag   2460

cagggcacaa ccaagagagc taaagacccc tgggtaaagc cacctcctgc ccccaagtcc   2520

ttccctgacg cagacttgct ggacaaccag gtgcgtcaac atgcaggtac aggggcagac   2580

ccttctccct tccctcctcc tccatgcctt tcacaactat ttgctgagtg tcactgtgcc   2640

aagccctggg gctaaaacta atcaagattt ggttcttctg tacacttaaa agtggttaaa   2700

atggtcaatt ttatgttacg tatattttac cacaatttaa aataaatttg aaaaaaaatt   2760


<210>  1951
<211>  59
<212>  PRT
<213>  Homo sapiens

<400>  1951


Met Arg Leu Gly Thr Phe Ser Arg Pro Gln Ala Pro Ala Leu Gln Thr 
1               5                   10                  15      


Glu Gly Thr Arg Gly Val Val Lys Val Pro Glu Pro Pro Phe Arg Arg 
            20                  25                  30          


Asn Pro Ser Arg Arg Cys Leu Ser Lys Pro Cys Arg Lys Ser Ser Arg 
        35                  40                  45              


Pro Pro Ser Ser Gln Cys Gln Pro Gln Asn Leu 
    50                  55                  

<210>  1952
<211>  1953
<212>  DNA
<213>  Homo sapiens

<400>  1952
tttctcatct ctaaaatggg gatgacaata gtaactacct cattgggttg ttttaagaat     60

tacatgactt aatgtatgtc caattcttag aacagtgatg cttaggatat agtaaatgat    120

aacatagatg aggaaattga gaggcaggga agctgactgg tccaaggtcc tgcagctaaa    180

caatggcagg gcagagagca cagcgcggat tcaccccact ggtttaatac tctgtttcaa    240

accatcgatg aatgcaggct cttgttgacg tgggcattac tctgcccctc accgggatgt    300

tactgccatt ctgttgctaa atcaccagga tgaggttagg aaccttctcc aggcctcagg    360

ctcctgctct gcaaactgaa ggaactagag gtgtggttaa ggtgcctgaa ccccctttta    420

ggagaaatcc cagcagaaga tgcctaagca agccttgcag gaagtcatct aggccacctt    480

caagtcagtg ccaaccgcag aatctttaga tcccccaaaa gagcacctgt ccctttgtgg    540

tgcttctgac agagaacccc aagcagcccc tagaactgcg tgtggacagc tagaaagcct    600

agcctttctg acattgctgg cctaagaggt ttcatcttta gggttttttt ccttctcagg    660

ctgctagctt ccatctcact taatacagaa ggatggtctc aatttaagca tctgaaacaa    720

attacttagc aaaaaccatt ttcgttgtat ccaaacccag tgtcttcagt ttgagctctc    780

tgaaattcca aacacatgtt caaaccacca ggaaagaggg aaagagagac tgagaagagg    840

gggactgaag cagggaagtc actatgagat tctccccaaa atcccgatgt tcagcctctg    900

ggtgaaggac attccatcct gagacggagg gattgctctc ttcaccagca cctttctgaa    960

gtgtctgtgt tagaggcagt tcagtgctca cacagcagcc tgaaattctt agtcctccca   1020

cacatctcca gtcaaggagc actgtccatg ccccttcatt gtccataaac acccaagctc   1080

ttatttagaa gcaattgatt tctcaaatct tttcctatgt atttattcac taaacctgtc   1140

aagcaacaca tttaagcatg acagagaaag aatatgggca tgtgttagga ttccctagag   1200

aaacagaacc aatagggtga gtatatggag aggagaggtt tagtttaagg aagtacctca   1260

tgcagttacg gaggctggca agtccaaaat ctacagggta ggccaggcag gctgaagact   1320

cagagaagag cctatactgc agttccagtc caaaagctgt ctgctgcaca gttccctctt   1380

actcagggaa gctcagtctt tgattccatt ccagccttca gttgatcaga tgaggcccac   1440

ccacattaca gagggccatc cgtttactca aagcccactg atttcaatat aaacctcatc   1500

ccaaaacacc ctcccagaaa catccagaat aatgtttgac caactatctg ggtactaaag   1560

cccagccaag ttggcacatc aaattaatca ttgcagggtg tgagcaggag aaaaaagaag   1620

agatgagatt gccctgagcc caaatccaga aagcagggca caaccaagag agctaaagac   1680

ccctgggtaa agccacctcc tgcccccaag tccttccctg acgcagactt gctggacaac   1740

caggtgcgtc aacatgcagg tacaggggca gacccttctc ccttccctcc tcctccatgc   1800

ctttcacaac tatttgctga gtgtcactgt gccaagccct ggggctaaaa ctaatcaaga   1860

tttggttctt ctgtacactt aaaagtggtt aaaatggtca attttatgtt acgtatattt   1920

taccacaatt taaaataaat ttgaaaaaaa att                                1953


<210>  1953
<211>  59
<212>  PRT
<213>  Homo sapiens

<400>  1953


Met Arg Leu Gly Thr Phe Ser Arg Pro Gln Ala Pro Ala Leu Gln Thr 
1               5                   10                  15      


Glu Gly Thr Arg Gly Val Val Lys Val Pro Glu Pro Pro Phe Arg Arg 
            20                  25                  30          


Asn Pro Ser Arg Arg Cys Leu Ser Lys Pro Cys Arg Lys Ser Ser Arg 
        35                  40                  45              


Pro Pro Ser Ser Gln Cys Gln Pro Gln Asn Leu 
    50                  55                  

<210>  1954
<211>  706
<212>  DNA
<213>  Homo sapiens

<400>  1954
atcaggttca acgcagtgac tgctcagtag aagccatggc tcgcagacac tgcttctcct     60

actggttact ggtatgctgg ttggtggtaa ctgtggcaga aggacaagaa gaggtattta    120

cgcctcctgg agattcacaa aataatgcgg acgctaccga ctgccagatc tttacactca    180

cccctccacc tgccccgagg agtccggtca caagggccca gcccatcaca aagacaccca    240

ggtgtccctt ccattttttt ccacgaaggc ccagaatcca ttttaggttt ccaaacagac    300

ctttcgtccc ttcaaggtgt aaccaccgtt ttccattcca gccattttat tggccacacc    360

gttaccttac ttataggtat ttccccagaa gaagactcca gagaggaagc tcatctgagg    420

aaagctgaga gggaagagaa acccaaacat actgaagcaa aaaaaagcct atccttcaga    480

aaaaagcaac aaaaagattt ctgttttatc tttcgaaact aaaactattg gatttgaaga    540

ttaagtatcc taaacatcac tgactagaaa ctgttctctt tgtcagcagt gaagatattg    600

gatcataggt tattgatggt tgcaaaattg gacaataacc acgttatttt tatcctcaac    660

ctcttatggt cacaggatat ttatgcaaat aaaatcttta aatggg                   706


<210>  1955
<211>  130
<212>  PRT
<213>  Homo sapiens

<400>  1955


Met Ala Arg Arg His Cys Phe Ser Tyr Trp Leu Leu Val Cys Trp Leu 
1               5                   10                  15      


Val Val Thr Val Ala Glu Gly Gln Glu Glu Val Phe Thr Pro Pro Gly 
            20                  25                  30          


Asp Ser Gln Asn Asn Ala Asp Ala Thr Asp Cys Gln Ile Phe Thr Leu 
        35                  40                  45              


Thr Pro Pro Pro Ala Pro Arg Ser Pro Val Thr Arg Ala Gln Pro Ile 
    50                  55                  60                  


Thr Lys Thr Pro Arg Cys Pro Phe His Phe Phe Pro Arg Arg Pro Arg 
65                  70                  75                  80  


Ile His Phe Arg Phe Pro Asn Arg Pro Phe Val Pro Ser Arg Cys Asn 
                85                  90                  95      


His Arg Phe Pro Phe Gln Pro Phe Tyr Trp Pro His Arg Tyr Leu Thr 
            100                 105                 110         


Tyr Arg Tyr Phe Pro Arg Arg Arg Leu Gln Arg Gly Ser Ser Ser Glu 
        115                 120                 125             


Glu Ser 
    130 

<210>  1956
<211>  1850
<212>  DNA
<213>  Homo sapiens

<400>  1956
gactgctcag tagaagccat ggctcgcaga cactgcttct cctactggtt actggtatgc     60

tggttggtgg taactgtggc agaaggacaa gaagaggtat ttacgcctcc tggagattca    120

caaaataatg cggacgctac cgactgccag atctttacac tcacccctcc acctgccccg    180

aggagtccgg tcacaagggc ccagcccatc acaaagacac ccaggtgtcc cttccatttt    240

tttccacgaa ggcccagaat ccattttagg tttccaaaca gacctttcgt cccttcaagg    300

tgtaaccacc gttttccatt ccagccattt tattggccac accgttacct tacttatagg    360

tatttcccca gaagaagact ccagagagga agctcatctg aggaaagctg agagggaaga    420

gaaacccaaa catactgaag caaaaaaaag cctatccttc agaaaaaagc aacaaaaaga    480

tttctgtttt atctttcgaa actaaaacta ttggatttga agattaagta tcctaaacat    540

cactgactag aaactgttct ctttgtcagc agtgaagata ttggatcata ggttattgat    600

ggttgcaaaa ttggacaata accacgttat ttttatcctc aacctcttat ggtcacagga    660

tatttatgca aataaaatct ttaaatgggt ggctctagta attcctatcc atactaagat    720

gctgagagaa tccatctcct cctctaaatt aaacaggatt taaataaatt gagatcatta    780

taaaccacac gaagaaactg atgacaccgt ttttatactc attggaaaac atacagagca    840

aggtgcattg acaaagtaaa ctttaaaaga aattataaag cttaaagcaa ttaaaaagtt    900

atgaggagtc tgactgtagc taatacttta aagatataaa ctgacttgtc taacccaaat    960

aataataatt attattattt tcttggagac agaatttcac tcttgttacc caggctggag   1020

tttagtggtg ctgtctcggc tcactgcaac ctctgcctcc cgggttcaag caattctctt   1080

gcctcagcct cccaagtagc tgggattata ggtgctcgct accaagcctg gccaattttt   1140

tgtattttta gtagagatgg ggtttcacca tgttggccag gctggtctcg aactcctgac   1200

ctcaggtgat ccacccacct cggcctccca gagtgctggg attacaggca tgagtcactg   1260

cgcccagccc caaataatta cttttaaact atagtatcta aatttacttt aatgttgact   1320

tcaactgatg caaattaatt tgataatttt ctcactgttt cccgttatca ttacatagat   1380

gctggctaaa ataatatact tcctctcaaa cttttaacgt aattccaggt tcaaaatgcc   1440

tgattaaact gctacaagaa tattctggta cctctagaac tccacagaga taagttcact   1500

caactcttgg aaccttgtat tctcagggtg caatatgaga aacaaatccc acagattgca   1560

ttgattggtt atttgttttg gccactctgt aaaacacatc ttcctgttta tgccacttat   1620

cttgcctgta acataagaac tttagttctg catatgtggt cagtggtttg cactttttcc   1680

tcccaagatc tacatgcaaa agttgctgtt gctgctgctg ctacaaaaac agaaaaaaaa   1740

aaatcaggat gaagacatga aaggactttg ggaatggttg ccctaaaaaa ggaaagagag   1800

ataaaatcat catgctatgt ttctttgctt tattaaaatg atcaaaaaag              1850


<210>  1957
<211>  130
<212>  PRT
<213>  Homo sapiens

<400>  1957


Met Ala Arg Arg His Cys Phe Ser Tyr Trp Leu Leu Val Cys Trp Leu 
1               5                   10                  15      


Val Val Thr Val Ala Glu Gly Gln Glu Glu Val Phe Thr Pro Pro Gly 
            20                  25                  30          


Asp Ser Gln Asn Asn Ala Asp Ala Thr Asp Cys Gln Ile Phe Thr Leu 
        35                  40                  45              


Thr Pro Pro Pro Ala Pro Arg Ser Pro Val Thr Arg Ala Gln Pro Ile 
    50                  55                  60                  


Thr Lys Thr Pro Arg Cys Pro Phe His Phe Phe Pro Arg Arg Pro Arg 
65                  70                  75                  80  


Ile His Phe Arg Phe Pro Asn Arg Pro Phe Val Pro Ser Arg Cys Asn 
                85                  90                  95      


His Arg Phe Pro Phe Gln Pro Phe Tyr Trp Pro His Arg Tyr Leu Thr 
            100                 105                 110         


Tyr Arg Tyr Phe Pro Arg Arg Arg Leu Gln Arg Gly Ser Ser Ser Glu 
        115                 120                 125             


Glu Ser 
    130 

<210>  1958
<211>  541
<212>  DNA
<213>  Homo sapiens

<400>  1958
gaagccatgg ctcgcagaca ctgcttctcc tactggttac tggtatgctg gttggtggta     60

actgtggcag aaggacaaga agaggtattt acgcctcctg gagattcaca aaataatgcg    120

gacgctaccg actgccagat ctttacactc acccctccac ctgccccgag gagtccggtc    180

acaagggccc agcccatcac aaagacaccc aggtatttcc ccagaagaag actccagaga    240

ggaagctcat ctgaggaaag ctgagaggga agagaaaccc aaacatactg aagcaaaaaa    300

aagcctatcc ttcagaaaaa agcaacaaaa agatttctgt tttatctttc gaaactaaaa    360

ctattggatt tgaagattaa gtatcctaaa catcactgac tagaaactgt tctctttgtc    420

agcagtgaag atattggatc ataggttatt gatggttgca aaattggaca ataaccacgt    480

tatttttatc ctcaacctct tatggtcaca ggatatttat gcaaataaaa tctttaaatg    540

g                                                                    541


<210>  1959
<211>  85
<212>  PRT
<213>  Homo sapiens

<400>  1959


Met Ala Arg Arg His Cys Phe Ser Tyr Trp Leu Leu Val Cys Trp Leu 
1               5                   10                  15      


Val Val Thr Val Ala Glu Gly Gln Glu Glu Val Phe Thr Pro Pro Gly 
            20                  25                  30          


Asp Ser Gln Asn Asn Ala Asp Ala Thr Asp Cys Gln Ile Phe Thr Leu 
        35                  40                  45              


Thr Pro Pro Pro Ala Pro Arg Ser Pro Val Thr Arg Ala Gln Pro Ile 
    50                  55                  60                  


Thr Lys Thr Pro Arg Tyr Phe Pro Arg Arg Arg Leu Gln Arg Gly Ser 
65                  70                  75                  80  


Ser Ser Glu Glu Ser 
                85  

<210>  1960
<211>  742
<212>  DNA
<213>  Homo sapiens

<400>  1960
agtagagacg gggtttcacc atgttagcca ggatggtctc gatctcctga cctcgtgatc     60

tgccagcctc ggcctcccaa agttctggga ttacaggcat gagccacagc gcccggccaa    120

aatccgcaca tcttaaagga caagaagagg tatttacgcc tcctggagat tcacaaaata    180

atgcggacgc taccgactgc cagatcttta cactcacccc tccacctgcc ccgaggagtc    240

cggtcacaag ggcccagccc atcacaaaga cacccaggtg tcccttccat ttttttccac    300

gaaggcccag aatccatttt aggtttccaa acagaccttt cgtcccttca aggtgtaacc    360

accgttttcc attccagcca ttttattggc cacaccgtta ccttacttat aggtatttcc    420

ccagaagaag actccagaga ggaagctcat ctgaggaaag ctgagaggga agagaaaccc    480

aaacatactg aagcaaaaaa aagcctatcc ttcagaaaaa agcaacaaaa agatttctgt    540

tttatctttc gaaactaaaa ctattggatt tgaagattaa gtatcctaaa catcactgac    600

tagaaactgt tctctttgtc agcagtgaag atattggatc ataggttatt gatggttgca    660

aaattggaca ataaccacgt tatttttatc ctcaacctct tatggtcaca ggatatttat    720

gcaaataaaa tctttaaatg gg                                             742


<210>  1961
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  1961


Met Ser His Ser Ala Arg Pro Lys Ser Ala His Leu Lys Gly Gln Glu 
1               5                   10                  15      


Glu Val Phe Thr Pro Pro Gly Asp Ser Gln Asn Asn Ala Asp Ala Thr 
            20                  25                  30          


Asp Cys Gln Ile Phe Thr Leu Thr Pro Pro Pro Ala Pro Arg Ser Pro 
        35                  40                  45              


Val Thr Arg Ala Gln Pro Ile Thr Lys Thr Pro Arg Cys Pro Phe His 
    50                  55                  60                  


Phe Phe Pro Arg Arg Pro Arg Ile His Phe Arg Phe Pro Asn Arg Pro 
65                  70                  75                  80  


Phe Val Pro Ser Arg Cys Asn His Arg Phe Pro Phe Gln Pro Phe Tyr 
                85                  90                  95      


Trp Pro His Arg Tyr Leu Thr Tyr Arg Tyr Phe Pro Arg Arg Arg Leu 
            100                 105                 110         


Gln Arg Gly Ser Ser Ser Glu Glu Ser 
        115                 120     

<210>  1962
<211>  1232
<212>  DNA
<213>  Homo sapiens

<400>  1962
agtaagaaaa gaagagaata ctccaggaca gatgtccgtt tgcctgaact aaactataat     60

catctccctg aactaagagc actgggaggc atagctcgaa attccaggct aacaaagaaa    120

gagagcaaaa ttctttcaga atctcgaatt ccttctctgg ctgctattga cctgcacacc    180

cccagtatta cattacatca gatgatgctc ttgcacttga gatgacatct tcttgcagca    240

agagtgctga tatcccaaga ggagagattc atggttttga tcatttcctt ctgaactgcc    300

tgcattttct gaggaaggcc ttctagaaga aggaaagaca aagacttcca aatgtttcaa    360

aggaagattg aacaaatggc cctccccaac tgttatccca ttacctttca cgtccaccga    420

tgctatttca agacatatcc agtggaataa cagtgatatg gttcttgtta catgaatgtg    480

tatttactgt taggagattg tatattttaa gttaccatga ttaaaagtgt gtaaaaaagg    540

gggacagaga gaaatactat aaaaggccat gttactcatg cattgaactt tgtgtgtttt    600

ctgtataaat gtgtacattt atttaggagt gggtttcttg ggggtaggtg ataaaaatta    660

ggatcagttg aagaaaattg aagaaactag gatcagtaag agaaactgtt tgctttacct    720

gaatttaact atgaaaacac acttaacaat cttacacgtt tctagatatt aagtgaatat    780

gtaactcctg tccatgggta gatgtgtatc tttgacttct gtaattattt ttgatattct    840

atcagtgtat tatgagactc tggcctccct gcagatcttc taagaaccac actaatgcaa    900

gcgtgacaga gaaacctctt tcgaatgact tactacaact ctggcattgg ttagttccat    960

gtattgtaag attctggtgc taatgctcca tacagaattg atcaggactg attactcttc   1020

tgtggaccaa ttgctattga actacccagc tgaagagggt ttggggagag aacgttcatt   1080

attatggact ccacttttgt cccctggtag tttaagggtg atactagaat ccagagaagt   1140

tcctgtctcc ttgtggcctc aaacactcag gccgtctcaa aagcttttca ccaaggtgca   1200

aaatcattta cctgcattcc acacatcttt tc                                 1232


<210>  1963
<211>  90
<212>  PRT
<213>  Homo sapiens

<400>  1963


Met Tyr Cys Lys Ile Leu Val Leu Met Leu His Thr Glu Leu Ile Arg 
1               5                   10                  15      


Thr Asp Tyr Ser Ser Val Asp Gln Leu Leu Leu Asn Tyr Pro Ala Glu 
            20                  25                  30          


Glu Gly Leu Gly Arg Glu Arg Ser Leu Leu Trp Thr Pro Leu Leu Ser 
        35                  40                  45              


Pro Gly Ser Leu Arg Val Ile Leu Glu Ser Arg Glu Val Pro Val Ser 
    50                  55                  60                  


Leu Trp Pro Gln Thr Leu Arg Pro Ser Gln Lys Leu Phe Thr Lys Val 
65                  70                  75                  80  


Gln Asn His Leu Pro Ala Phe His Thr Ser 
                85                  90  

<210>  1964
<211>  2057
<212>  DNA
<213>  Homo sapiens

<400>  1964
gcagctccgc ggccaacgcc ttcgcccagg ggtagttgga gcggtgcagg ttcccaggct     60

ccaggtactg ggcgccttac gagctgggag gtggtgcctc tcacccagct aattgctctc    120

tagcccttgg ccttcacagg tgttggtgcc tgccgtgaac gcattctgac ctgggccgta    180

tctgtctccc aagactttgt gcctatggtt ggggacagag tgaggtcgtt gccttgacga    240

cgacagcatg cggcccgtgg tcctcctaag tgtgagcttg cggcggaccg aggcccacct    300

gcctccctgc ctgcttcgcc ctggactcgt gactgcgtcc gcagaagaaa tcacaacagc    360

gctggaattg ctagtttgct aggcagcatc ttttggacct gcgaaccata tgcatttcac    420

ctcaaatttg tttccaagtt gaaaaccttt gggtctttct atgcgaacgg attgaagaaa    480

cgcaaaaagt ttctacggac tttaaattaa aatggaaaaa tatgaaaacc tgggtttggt    540

tggagaaggg agttatggaa tggtgatgaa gtgtaggaat aaagatactg gaagaattgt    600

ggccataaag aagttcttag aaagtgacga tgacaaaatg gttaaaaaga ttgcaatgcg    660

agaaatcaag ttactaaagc aacttaggca tgaaaacttg gtgaatctct tggaagtgtg    720

taagaaaaaa aaacgatggt acctagtctt tgaatttgtt gaccacacaa ttcttgatga    780

cttggagctc tttccaaatg gactagacta ccaagtagtt caaaagtatt tgtttcagat    840

tattaatgga attggatttt gtcacagtca caatatcata cacagagata taaagccaga    900

gaatatatta gtctcccagt ctggcgttgt caagctatgc gattttggat ttgcgcgaac    960

attggcagct cctggggagg tttatactga ttatgtggca acccgatggt acagagctcc   1020

agaactattg gttggtgatg tcaagtatgg caaggctgtt gatgtgtggg ccattggttg   1080

tctggtaact gaaatgttca tgggggaacc cctatttcct ggagattctg atattgatca   1140

gctatatcat attatgatgt gtttaggtaa tctaattcca aggcatcagg agctttttaa   1200

taaaaatcct gtgtttgctg gagtaaggtt gcctgaaatc aaggaaagag aacctcttga   1260

aagacgctat cctaagctct ctgaagtggt gatagattta gcaaagaaat gcttacatat   1320

tgaccccgac aaaagaccct tctgtgctga gctcctacac catgatttct ttcaaatgga   1380

tggatttgct gagaggtttt cccaagaact acagttaaaa gtacagaaag atgccagaaa   1440

tgtttcttta tctaaaaaat cccaaaacag aaagaaggaa aaagaaaaag atgattcctt   1500

agttgaagaa agaaaaacac ttgtggtaca ggataccaat gctgatccca aaattaagga   1560

ttataaacta tttaaaataa aaggctcaaa aattgatgga gaaaaagctg aaaaaggcaa   1620

tagagcttca aatgccagct gtctccatga cagtaggaca agccacaaca aaatagtgcc   1680

ttcaacaagc ctcaaagact gcagcaatgt cagcgtggac cacacaagga atccaagcgt   1740

ggcaattccc ccacttacac acaatctttc tgcagttgct cccagcatta attctggaat   1800

ggggactgag actataccaa ttcagggtta cagagtggat gagaaaacta agaagtgttc   1860

tattccattt gttaaaccga acagacattc cccatcaggc atttataaca ttaatgtgac   1920

cacattagta tcaggacctc ccctgtcaga tgattcaggg gctgatttgc ctcaaatgga   1980

acaccagcac tgagaaccat tttggttctg aactggatga tgctcttgca cttgagatga   2040

catcttcttg cagcaag                                                  2057


<210>  1965
<211>  493
<212>  PRT
<213>  Homo sapiens

<400>  1965


Met Glu Lys Tyr Glu Asn Leu Gly Leu Val Gly Glu Gly Ser Tyr Gly 
1               5                   10                  15      


Met Val Met Lys Cys Arg Asn Lys Asp Thr Gly Arg Ile Val Ala Ile 
            20                  25                  30          


Lys Lys Phe Leu Glu Ser Asp Asp Asp Lys Met Val Lys Lys Ile Ala 
        35                  40                  45              


Met Arg Glu Ile Lys Leu Leu Lys Gln Leu Arg His Glu Asn Leu Val 
    50                  55                  60                  


Asn Leu Leu Glu Val Cys Lys Lys Lys Lys Arg Trp Tyr Leu Val Phe 
65                  70                  75                  80  


Glu Phe Val Asp His Thr Ile Leu Asp Asp Leu Glu Leu Phe Pro Asn 
                85                  90                  95      


Gly Leu Asp Tyr Gln Val Val Gln Lys Tyr Leu Phe Gln Ile Ile Asn 
            100                 105                 110         


Gly Ile Gly Phe Cys His Ser His Asn Ile Ile His Arg Asp Ile Lys 
        115                 120                 125             


Pro Glu Asn Ile Leu Val Ser Gln Ser Gly Val Val Lys Leu Cys Asp 
    130                 135                 140                 


Phe Gly Phe Ala Arg Thr Leu Ala Ala Pro Gly Glu Val Tyr Thr Asp 
145                 150                 155                 160 


Tyr Val Ala Thr Arg Trp Tyr Arg Ala Pro Glu Leu Leu Val Gly Asp 
                165                 170                 175     


Val Lys Tyr Gly Lys Ala Val Asp Val Trp Ala Ile Gly Cys Leu Val 
            180                 185                 190         


Thr Glu Met Phe Met Gly Glu Pro Leu Phe Pro Gly Asp Ser Asp Ile 
        195                 200                 205             


Asp Gln Leu Tyr His Ile Met Met Cys Leu Gly Asn Leu Ile Pro Arg 
    210                 215                 220                 


His Gln Glu Leu Phe Asn Lys Asn Pro Val Phe Ala Gly Val Arg Leu 
225                 230                 235                 240 


Pro Glu Ile Lys Glu Arg Glu Pro Leu Glu Arg Arg Tyr Pro Lys Leu 
                245                 250                 255     


Ser Glu Val Val Ile Asp Leu Ala Lys Lys Cys Leu His Ile Asp Pro 
            260                 265                 270         


Asp Lys Arg Pro Phe Cys Ala Glu Leu Leu His His Asp Phe Phe Gln 
        275                 280                 285             


Met Asp Gly Phe Ala Glu Arg Phe Ser Gln Glu Leu Gln Leu Lys Val 
    290                 295                 300                 


Gln Lys Asp Ala Arg Asn Val Ser Leu Ser Lys Lys Ser Gln Asn Arg 
305                 310                 315                 320 


Lys Lys Glu Lys Glu Lys Asp Asp Ser Leu Val Glu Glu Arg Lys Thr 
                325                 330                 335     


Leu Val Val Gln Asp Thr Asn Ala Asp Pro Lys Ile Lys Asp Tyr Lys 
            340                 345                 350         


Leu Phe Lys Ile Lys Gly Ser Lys Ile Asp Gly Glu Lys Ala Glu Lys 
        355                 360                 365             


Gly Asn Arg Ala Ser Asn Ala Ser Cys Leu His Asp Ser Arg Thr Ser 
    370                 375                 380                 


His Asn Lys Ile Val Pro Ser Thr Ser Leu Lys Asp Cys Ser Asn Val 
385                 390                 395                 400 


Ser Val Asp His Thr Arg Asn Pro Ser Val Ala Ile Pro Pro Leu Thr 
                405                 410                 415     


His Asn Leu Ser Ala Val Ala Pro Ser Ile Asn Ser Gly Met Gly Thr 
            420                 425                 430         


Glu Thr Ile Pro Ile Gln Gly Tyr Arg Val Asp Glu Lys Thr Lys Lys 
        435                 440                 445             


Cys Ser Ile Pro Phe Val Lys Pro Asn Arg His Ser Pro Ser Gly Ile 
    450                 455                 460                 


Tyr Asn Ile Asn Val Thr Thr Leu Val Ser Gly Pro Pro Leu Ser Asp 
465                 470                 475                 480 


Asp Ser Gly Ala Asp Leu Pro Gln Met Glu His Gln His 
                485                 490             

<210>  1966
<211>  400
<212>  DNA
<213>  Homo sapiens

<400>  1966
gaaaaaaacc tcttttgggc aagtaagaaa agaagagaat actccaggac agatgtccgt     60

ttgcctgaac taaactataa tcatctccct gaactaagag cactgggagg catagctcga    120

aattccaggc taacaaagaa agagagcaaa attctttcag aatctcgaat tccttctctg    180

gctgctattg acctgcacac ccccagtatt acattacatc aggtatcagg acctcccctg    240

tcagatgatt caggggctga tttgcctcaa atggaacacc agcactgaga accattttgg    300

ttctgaactg ggtaggtgtg atttcccata cttaaagctg tgcagccttt cacaggtact    360

attttgtggc ttgctgaata ccaatttttc agctgaaacc                          400


<210>  1967
<211>  51
<212>  PRT
<213>  Homo sapiens

<400>  1967


Met Ile Gln Gly Leu Ile Cys Leu Lys Trp Asn Thr Ser Thr Glu Asn 
1               5                   10                  15      


His Phe Gly Ser Glu Leu Gly Arg Cys Asp Phe Pro Tyr Leu Lys Leu 
            20                  25                  30          


Cys Ser Leu Ser Gln Val Leu Phe Cys Gly Leu Leu Asn Thr Asn Phe 
        35                  40                  45              


Ser Ala Glu 
    50      

<210>  1968
<211>  2922
<212>  DNA
<213>  Homo sapiens

<400>  1968
gcttactcag atttacttca tgtttaccaa cttcttggtt tgttctttct tgtatctcac     60

cccttctttc tgaattcaat tttcttcttc ttaaaccaca tctgctagta gttcattagt    120

gagagtctct tatattgtta aattaagcca taggctattt ctgagtttca gcagtttgtt    180

acctacaact tatggttcaa cctactggta gattctctca gtattttatt tctcagtatt    240

ttgctcttat attttgcata agctcatgaa cagacatctc taattttaac cagtgcagat    300

ttcccttact tccttaagaa ctcattgagg aagaagatgg cattttatat agtattttta    360

gatattttta ggttggtacg tttttcagat tattaaccta taagattgcc tcaaatggct    420

cttgtttgtt ctcatggcac agcctcatga tctgaaataa ttacaaatct tggcttcacc    480

ttgttttatt tttgcttttt atcctagtta gtctaatatt tatattgtca ttactgttct    540

atttttgttt ccatttacct gatgcatctt tgctcaattt tttattttta acctattttc    600

cccatttact tctagagaga agcaaggaac aattgaatgt cctagaagaa tagttcactg    660

taaatcatca tctctaggat aatacgtcac tgaggaagtc tcttctcaca aattctgagc    720

aaattgagaa gtccaagcaa tggcacacag atgccaaaat atcaccttaa tactgtcaag    780

gctgaagtga agatgtagct tactgtaaaa gcaaaattga cctacaggaa ttaaactaac    840

ctaaccttcc aagtcttagg caataattga accaaccagc taaagtttac agcatggggc    900

aggcagagag attcccaaaa ggaaaagatg gaaatttttt tttttttttt ttttagacag    960

agtctcactc tgttgcccag gctggagtgc agtggcacga tctcagctca ttgcaacctc   1020

cacctcctgg gttcaagtga ttctcctgcc tcagcctccc gaatagctga gactacaggt   1080

gtaggccacc acacccagct aatttttgta tttttggtag agataggatt ttcaccatat   1140

tggccaggct ggtctcgaac tcttgacctc aggtaatcca ccctccttgg cctcccaaag   1200

tgctgggatt acaggcgtga gccaccaccc ccagccaagt tttagttaat ctttacaaaa   1260

cccagtgagg tagttatatt cccttttata gatgaaggta ctgaggctca gagtttcggt   1320

atcttgccca agctgtaact cctatataga gaatgagagg acattactct agtttcttac   1380

ctgctacagt agggttataa atgcaaagta ctaattattc taccataatg tttcctttat   1440

tctatttgca gaggtgctga tactcaaaga aggtttaagt tgtctgatct ctctataaat   1500

tccactgaat gtctacatgt gcattgccga ggattagaga ccagtttggc tgaatgtact   1560

tttactaaga gaagaactat gggttaccag gatttcgctg atgtggtttg ttatacacag   1620

aaagcagatt ctccaatgga tgacttcttt cagtgtgtga atgggaaata catttctcag   1680

atgaaagcct gtgatggtat caatgattgt ggagaccaaa gtgatgaact gtgttgtaaa   1740

gcatgccaag gcaaaggctt ccattgcaaa tcgggtgttt gcattccaag ccagtatcaa   1800

tgcaatggtg aggtggactg cattacaggg gaagatgaag ttggctgtgc aggctttgca   1860

tctgtgactc aagaagaaac agaaattttg actgctgaca tggatgcaga aagaagacgg   1920

ataaaatcat tattacctaa actatcttgt ggagttaaaa acagaatgca cattcgaagg   1980

aaacgaattg tgggaggaaa gcgagcacaa ctgggagacc tcccatggca ggtggcaatt   2040

aaggatgcca gtggaatcac ctgtggggga atttatattg gtggctgttg gattctgact   2100

gctgcacatt gtctcagagc cagtaaaact catcgttacc aaatatggac aacagtagta   2160

gactggatac accccgacct taaacgtata gtaattgaat acgtggatag aattattttc   2220

catgaaaact acaatgcagg cacttaccaa aatgacatcg ctttgattga aatgaaaaaa   2280

gacggaaaca aaaaagattg tgagctgcct cgttccatcc ctgcctgtgt cccctggtct   2340

ccttacctat tccaacctaa tgatacatgc atcgtttctg gctggggacg agaaaaagat   2400

aacgaaagag tcttttcact tcagtggggt gaagttaaac taataagcaa ctgctctaag   2460

ttttacggaa atcgtttcta tgaaaaagaa atggaatgtg caggtacata tgatggttcc   2520

atcgatgcct gtaaagggga ctctggaggc cccttagtct gtatggatgc caacaatgtg   2580

acttatgtct ggggtgttgt gagttggggg gaaaactgtg gaaaaccaga gttcccaggt   2640

gtttacacca aagtggccaa ttattttgac tggattagct accatgtagg aaggcctttt   2700

atttctcagt acaatgtata aaattgtgat ctctctcttc attctattct ttttctctca   2760

agagttccat ttaatggaaa taaaacggta taattaataa ttctctaggg gggaaaaatg   2820

aagcaaatct cactggatat ttttaaaggt ctccacagag tttatgccat attggaattt   2880

tgttgtataa ttctcaaata aatattttgg tgaagcatac aa                      2922


<210>  1969
<211>  380
<212>  PRT
<213>  Homo sapiens

<400>  1969


Met Gly Tyr Gln Asp Phe Ala Asp Val Val Cys Tyr Thr Gln Lys Ala 
1               5                   10                  15      


Asp Ser Pro Met Asp Asp Phe Phe Gln Cys Val Asn Gly Lys Tyr Ile 
            20                  25                  30          


Ser Gln Met Lys Ala Cys Asp Gly Ile Asn Asp Cys Gly Asp Gln Ser 
        35                  40                  45              


Asp Glu Leu Cys Cys Lys Ala Cys Gln Gly Lys Gly Phe His Cys Lys 
    50                  55                  60                  


Ser Gly Val Cys Ile Pro Ser Gln Tyr Gln Cys Asn Gly Glu Val Asp 
65                  70                  75                  80  


Cys Ile Thr Gly Glu Asp Glu Val Gly Cys Ala Gly Phe Ala Ser Val 
                85                  90                  95      


Thr Gln Glu Glu Thr Glu Ile Leu Thr Ala Asp Met Asp Ala Glu Arg 
            100                 105                 110         


Arg Arg Ile Lys Ser Leu Leu Pro Lys Leu Ser Cys Gly Val Lys Asn 
        115                 120                 125             


Arg Met His Ile Arg Arg Lys Arg Ile Val Gly Gly Lys Arg Ala Gln 
    130                 135                 140                 


Leu Gly Asp Leu Pro Trp Gln Val Ala Ile Lys Asp Ala Ser Gly Ile 
145                 150                 155                 160 


Thr Cys Gly Gly Ile Tyr Ile Gly Gly Cys Trp Ile Leu Thr Ala Ala 
                165                 170                 175     


His Cys Leu Arg Ala Ser Lys Thr His Arg Tyr Gln Ile Trp Thr Thr 
            180                 185                 190         


Val Val Asp Trp Ile His Pro Asp Leu Lys Arg Ile Val Ile Glu Tyr 
        195                 200                 205             


Val Asp Arg Ile Ile Phe His Glu Asn Tyr Asn Ala Gly Thr Tyr Gln 
    210                 215                 220                 


Asn Asp Ile Ala Leu Ile Glu Met Lys Lys Asp Gly Asn Lys Lys Asp 
225                 230                 235                 240 


Cys Glu Leu Pro Arg Ser Ile Pro Ala Cys Val Pro Trp Ser Pro Tyr 
                245                 250                 255     


Leu Phe Gln Pro Asn Asp Thr Cys Ile Val Ser Gly Trp Gly Arg Glu 
            260                 265                 270         


Lys Asp Asn Glu Arg Val Phe Ser Leu Gln Trp Gly Glu Val Lys Leu 
        275                 280                 285             


Ile Ser Asn Cys Ser Lys Phe Tyr Gly Asn Arg Phe Tyr Glu Lys Glu 
    290                 295                 300                 


Met Glu Cys Ala Gly Thr Tyr Asp Gly Ser Ile Asp Ala Cys Lys Gly 
305                 310                 315                 320 


Asp Ser Gly Gly Pro Leu Val Cys Met Asp Ala Asn Asn Val Thr Tyr 
                325                 330                 335     


Val Trp Gly Val Val Ser Trp Gly Glu Asn Cys Gly Lys Pro Glu Phe 
            340                 345                 350         


Pro Gly Val Tyr Thr Lys Val Ala Asn Tyr Phe Asp Trp Ile Ser Tyr 
        355                 360                 365             


His Val Gly Arg Pro Phe Ile Ser Gln Tyr Asn Val 
    370                 375                 380 

<210>  1970
<211>  2116
<212>  DNA
<213>  Homo sapiens

<400>  1970
ggtttcagtt acggtaaatc tctctggatt tcagccaaat tctttcagag ttcaaaagta     60

caaagctctt taggaggttt gttcttttga aacatttttt cagaggttaa aaattaaatt    120

tcaaaagaat acctggagtg gaaaagagtt ctcagcagag acaaagaccc cgaacacctc    180

caacatgaag cttcttcatg ttttcctgtt atttctgtgc ttccacttaa ggttttgcaa    240

ggtcacttat acatctcaag aggatctggt ggagaaaaag tgcttagcaa aaaaatatac    300

tcacctctcc tgcgataaag tcttctgcca gccatggcag agatgcattg agggcacctg    360

tgtttgtaaa ctaccgtatc agtgcccaaa gaatggcact gcagtgtgtg caactaacag    420

gagaagcttc ccaacatact gtcaacaaaa gagtttggaa tgtcttcatc cagggacaaa    480

gtttttaaat aacggaacat gcacagccga aggaaagttt agtgtttcct tgaagcatgg    540

aaatacagat tcagagggaa tagttgaagt aaaacttgtg gaccaagata agacaatgtt    600

catatgcaaa agcagctgga gcatgaggga agccaacgtg gcctgccttg accttgggtt    660

tcaacaaggt gctgatactc aaagaaggtt taagttgtct gatctctcta taaattccac    720

tgaatgtcta catgtgcatt gccgaggatt agagaccagt ttggctgaat gtacttttac    780

taagagaaga actatgggtt accaggattt cgctgatgtg gtttgttata cacagaaagc    840

agattctcca atggatgact tctttcagtg tgtgaatggg aaatacattt ctcagatgaa    900

agcctgtgat ggtatcaatg attgtggaga ccaaagtgat gaactgtgtt gtaaagcatg    960

ccaaggcaaa ggcttccatt gcaaatcggg tgtttgcatt ccaagccagt atcaatgcaa   1020

tggtgaggtg gactgcatta caggggaaga tgaagttggc tgtgcagaag aaacagaaat   1080

tttgactgct gacatggatg cagaaagaag acggataaaa tcattattac ctaaactatc   1140

ttgtggagtt aaaaacagaa tgcacattcg aaggaaacga attgtgggag gaaagcgagc   1200

acaactggga gacctcccat ggcaggtggc aattaaggat gccagtggaa tcacctgtgg   1260

gggaatttat attggtggct gttggattct gactgctgca cattgtctca gagccagtaa   1320

aactcatcgt taccaaatat ggacaacagt agtagactgg atacaccccg accttaaacg   1380

tatagtaatt gaatacgtgg atagaattat tttccatgaa aactacaatg caggcactta   1440

ccaaaatgac atcgctttga ttgaaatgaa aaaagacgga aacaaaaaag attgtgagct   1500

gcctcgttcc atccctgcct gtgtcccctg gtctccttac ctattccaac ctaatgatac   1560

atgcatcgtt tctggctggg gacgagaaaa agataacgaa agagtctttt cacttcagtg   1620

gggtgaagtt aaactaataa gcaactgctc taagttttac ggaaatcgtt tctatgaaaa   1680

agaaatggaa tgtgcaggta catatgatgg ttccatcgat gcctgtaaag gggactctgg   1740

aggcccctta gtctgtatgg atgccaacaa tgtgacttat gtctggggtg ttgtgagttg   1800

gggggaaaac tgtggaaaac cagagttccc aggtgtttac accaaagtgg ccaattattt   1860

tgactggatt agctaccatg taggaaggcc ttttatttct cagtacaatg tataaaattg   1920

tgatctctct cttcattcta ttctttttct ctcaagagtt ccatttaatg gaaataaaac   1980

ggtataatta ataattctct aggggggaaa aatgaagcaa atctcactgg atatttttaa   2040

aggtctccac agagtttatg ccatattgga attttgttgt ataattctca aataaatatt   2100

ttggtgaagc atacaa                                                   2116


<210>  1971
<211>  576
<212>  PRT
<213>  Homo sapiens

<400>  1971


Met Lys Leu Leu His Val Phe Leu Leu Phe Leu Cys Phe His Leu Arg 
1               5                   10                  15      


Phe Cys Lys Val Thr Tyr Thr Ser Gln Glu Asp Leu Val Glu Lys Lys 
            20                  25                  30          


Cys Leu Ala Lys Lys Tyr Thr His Leu Ser Cys Asp Lys Val Phe Cys 
        35                  40                  45              


Gln Pro Trp Gln Arg Cys Ile Glu Gly Thr Cys Val Cys Lys Leu Pro 
    50                  55                  60                  


Tyr Gln Cys Pro Lys Asn Gly Thr Ala Val Cys Ala Thr Asn Arg Arg 
65                  70                  75                  80  


Ser Phe Pro Thr Tyr Cys Gln Gln Lys Ser Leu Glu Cys Leu His Pro 
                85                  90                  95      


Gly Thr Lys Phe Leu Asn Asn Gly Thr Cys Thr Ala Glu Gly Lys Phe 
            100                 105                 110         


Ser Val Ser Leu Lys His Gly Asn Thr Asp Ser Glu Gly Ile Val Glu 
        115                 120                 125             


Val Lys Leu Val Asp Gln Asp Lys Thr Met Phe Ile Cys Lys Ser Ser 
    130                 135                 140                 


Trp Ser Met Arg Glu Ala Asn Val Ala Cys Leu Asp Leu Gly Phe Gln 
145                 150                 155                 160 


Gln Gly Ala Asp Thr Gln Arg Arg Phe Lys Leu Ser Asp Leu Ser Ile 
                165                 170                 175     


Asn Ser Thr Glu Cys Leu His Val His Cys Arg Gly Leu Glu Thr Ser 
            180                 185                 190         


Leu Ala Glu Cys Thr Phe Thr Lys Arg Arg Thr Met Gly Tyr Gln Asp 
        195                 200                 205             


Phe Ala Asp Val Val Cys Tyr Thr Gln Lys Ala Asp Ser Pro Met Asp 
    210                 215                 220                 


Asp Phe Phe Gln Cys Val Asn Gly Lys Tyr Ile Ser Gln Met Lys Ala 
225                 230                 235                 240 


Cys Asp Gly Ile Asn Asp Cys Gly Asp Gln Ser Asp Glu Leu Cys Cys 
                245                 250                 255     


Lys Ala Cys Gln Gly Lys Gly Phe His Cys Lys Ser Gly Val Cys Ile 
            260                 265                 270         


Pro Ser Gln Tyr Gln Cys Asn Gly Glu Val Asp Cys Ile Thr Gly Glu 
        275                 280                 285             


Asp Glu Val Gly Cys Ala Glu Glu Thr Glu Ile Leu Thr Ala Asp Met 
    290                 295                 300                 


Asp Ala Glu Arg Arg Arg Ile Lys Ser Leu Leu Pro Lys Leu Ser Cys 
305                 310                 315                 320 


Gly Val Lys Asn Arg Met His Ile Arg Arg Lys Arg Ile Val Gly Gly 
                325                 330                 335     


Lys Arg Ala Gln Leu Gly Asp Leu Pro Trp Gln Val Ala Ile Lys Asp 
            340                 345                 350         


Ala Ser Gly Ile Thr Cys Gly Gly Ile Tyr Ile Gly Gly Cys Trp Ile 
        355                 360                 365             


Leu Thr Ala Ala His Cys Leu Arg Ala Ser Lys Thr His Arg Tyr Gln 
    370                 375                 380                 


Ile Trp Thr Thr Val Val Asp Trp Ile His Pro Asp Leu Lys Arg Ile 
385                 390                 395                 400 


Val Ile Glu Tyr Val Asp Arg Ile Ile Phe His Glu Asn Tyr Asn Ala 
                405                 410                 415     


Gly Thr Tyr Gln Asn Asp Ile Ala Leu Ile Glu Met Lys Lys Asp Gly 
            420                 425                 430         


Asn Lys Lys Asp Cys Glu Leu Pro Arg Ser Ile Pro Ala Cys Val Pro 
        435                 440                 445             


Trp Ser Pro Tyr Leu Phe Gln Pro Asn Asp Thr Cys Ile Val Ser Gly 
    450                 455                 460                 


Trp Gly Arg Glu Lys Asp Asn Glu Arg Val Phe Ser Leu Gln Trp Gly 
465                 470                 475                 480 


Glu Val Lys Leu Ile Ser Asn Cys Ser Lys Phe Tyr Gly Asn Arg Phe 
                485                 490                 495     


Tyr Glu Lys Glu Met Glu Cys Ala Gly Thr Tyr Asp Gly Ser Ile Asp 
            500                 505                 510         


Ala Cys Lys Gly Asp Ser Gly Gly Pro Leu Val Cys Met Asp Ala Asn 
        515                 520                 525             


Asn Val Thr Tyr Val Trp Gly Val Val Ser Trp Gly Glu Asn Cys Gly 
    530                 535                 540                 


Lys Pro Glu Phe Pro Gly Val Tyr Thr Lys Val Ala Asn Tyr Phe Asp 
545                 550                 555                 560 


Trp Ile Ser Tyr His Val Gly Arg Pro Phe Ile Ser Gln Tyr Asn Val 
                565                 570                 575     

<210>  1972
<211>  2137
<212>  DNA
<213>  Homo sapiens

<400>  1972
ggtttcagtt acggtaaatc tctctggatt tcagccaaat tctttcagag ttcaaaagta     60

caaagctctt taggaggttt gttcttttga aacatttttt cagaggttaa aaattaaatt    120

tcaaaagaat acctggagtg gaaaagagtt ctcagcagag acaaagaccc cgaacacctc    180

caacatgaag cttcttcatg ttttcctgtt atttctgtgc ttccacttaa ggttttgcaa    240

ggtcacttat acatctcaag aggatctggt ggagaaaaag tgcttagcaa aaaaatatac    300

tcacctctcc tgcgataaag tcttctgcca gccatggcag agatgcattg agggcacctg    360

tgtttgtaaa ctaccgtatc agtgcccaaa gaatggcact gcagtgtgtg caactaacag    420

gagaagcttc ccaacatact gtcaacaaaa gagtttggaa tgtcttcatc cagggacaaa    480

gtttttaaat aacggaacat gcacagccga aggaaagttt agtgtttcct tgaagcatgg    540

aaatacagat tcagagggaa tagttgaagt aaaacttgtg gaccaagata agacaatgtt    600

catatgcaaa agcagctgga gcatgaggga agccaacgtg gcctgccttg accttgggtt    660

tcaacaaggt gctgatactc aaagaaggtt taagttgtct gatctctcta taaattccac    720

tgaatgtcta catgtgcatt gccgaggatt agagaccagt ttggctgaat gtacttttac    780

taagagaaga actatgggtt accaggattt cgctgatgtg gtttgttata cacagaaagc    840

agattctcca atggatgact tctttcagtg tgtgaatggg aaatacattt ctcagatgaa    900

agcctgtgat ggtatcaatg attgtggaga ccaaagtgat gaactgtgtt gtaaagcatg    960

ccaaggcaaa ggcttccatt gcaaatcggg tgtttgcatt ccaagccagt atcaatgcaa   1020

tggtgaggtg gactgcatta caggggaaga tgaagttggc tgtgcaggct ttgcatctgt   1080

gactcaagaa gaaacagaaa ttttgactgc tgacatggat gcagaaagaa gacggataaa   1140

atcattatta cctaaactat cttgtggagt taaaaacaga atgcacattc gaaggaaacg   1200

aattgtggga ggaaagcgag cacaactggg agacctccca tggcaggtgg caattaagga   1260

tgccagtgga atcacctgtg ggggaattta tattggtggc tgttggattc tgactgctgc   1320

acattgtctc agagccagta aaactcatcg ttaccaaata tggacaacag tagtagactg   1380

gatacacccc gaccttaaac gtatagtaat tgaatacgtg gatagaatta ttttccatga   1440

aaactacaat gcaggcactt accaaaatga catcgctttg attgaaatga aaaaagacgg   1500

aaacaaaaaa gattgtgagc tgcctcgttc catccctgcc tgtgtcccct ggtctcctta   1560

cctattccaa cctaatgata catgcatcgt ttctggctgg ggacgagaaa aagataacga   1620

aagagtcttt tcacttcagt ggggtgaagt taaactaata agcaactgct ctaagtttta   1680

cggaaatcgt ttctatgaaa aagaaatgga atgtgcaggt acatatgatg gttccatcga   1740

tgcctgtaaa ggggactctg gaggcccctt agtctgtatg gatgccaaca atgtgactta   1800

tgtctggggt gttgtgagtt ggggggaaaa ctgtggaaaa ccagagttcc caggtgttta   1860

caccaaagtg gccaattatt ttgactggat tagctaccat gtaggaaggc cttttatttc   1920

tcagtacaat gtataaaatt gtgatctctc tcttcattct attctttttc tctcaagagt   1980

tccatttaat ggaaataaaa cggtataatt aataattctc taggggggaa aaatgaagca   2040

aatctcactg gatattttta aaggtctcca cagagtttat gccatattgg aattttgttg   2100

tataattctc aaataaatat tttggtgaag catacaa                            2137


<210>  1973
<211>  583
<212>  PRT
<213>  Homo sapiens

<400>  1973


Met Lys Leu Leu His Val Phe Leu Leu Phe Leu Cys Phe His Leu Arg 
1               5                   10                  15      


Phe Cys Lys Val Thr Tyr Thr Ser Gln Glu Asp Leu Val Glu Lys Lys 
            20                  25                  30          


Cys Leu Ala Lys Lys Tyr Thr His Leu Ser Cys Asp Lys Val Phe Cys 
        35                  40                  45              


Gln Pro Trp Gln Arg Cys Ile Glu Gly Thr Cys Val Cys Lys Leu Pro 
    50                  55                  60                  


Tyr Gln Cys Pro Lys Asn Gly Thr Ala Val Cys Ala Thr Asn Arg Arg 
65                  70                  75                  80  


Ser Phe Pro Thr Tyr Cys Gln Gln Lys Ser Leu Glu Cys Leu His Pro 
                85                  90                  95      


Gly Thr Lys Phe Leu Asn Asn Gly Thr Cys Thr Ala Glu Gly Lys Phe 
            100                 105                 110         


Ser Val Ser Leu Lys His Gly Asn Thr Asp Ser Glu Gly Ile Val Glu 
        115                 120                 125             


Val Lys Leu Val Asp Gln Asp Lys Thr Met Phe Ile Cys Lys Ser Ser 
    130                 135                 140                 


Trp Ser Met Arg Glu Ala Asn Val Ala Cys Leu Asp Leu Gly Phe Gln 
145                 150                 155                 160 


Gln Gly Ala Asp Thr Gln Arg Arg Phe Lys Leu Ser Asp Leu Ser Ile 
                165                 170                 175     


Asn Ser Thr Glu Cys Leu His Val His Cys Arg Gly Leu Glu Thr Ser 
            180                 185                 190         


Leu Ala Glu Cys Thr Phe Thr Lys Arg Arg Thr Met Gly Tyr Gln Asp 
        195                 200                 205             


Phe Ala Asp Val Val Cys Tyr Thr Gln Lys Ala Asp Ser Pro Met Asp 
    210                 215                 220                 


Asp Phe Phe Gln Cys Val Asn Gly Lys Tyr Ile Ser Gln Met Lys Ala 
225                 230                 235                 240 


Cys Asp Gly Ile Asn Asp Cys Gly Asp Gln Ser Asp Glu Leu Cys Cys 
                245                 250                 255     


Lys Ala Cys Gln Gly Lys Gly Phe His Cys Lys Ser Gly Val Cys Ile 
            260                 265                 270         


Pro Ser Gln Tyr Gln Cys Asn Gly Glu Val Asp Cys Ile Thr Gly Glu 
        275                 280                 285             


Asp Glu Val Gly Cys Ala Gly Phe Ala Ser Val Thr Gln Glu Glu Thr 
    290                 295                 300                 


Glu Ile Leu Thr Ala Asp Met Asp Ala Glu Arg Arg Arg Ile Lys Ser 
305                 310                 315                 320 


Leu Leu Pro Lys Leu Ser Cys Gly Val Lys Asn Arg Met His Ile Arg 
                325                 330                 335     


Arg Lys Arg Ile Val Gly Gly Lys Arg Ala Gln Leu Gly Asp Leu Pro 
            340                 345                 350         


Trp Gln Val Ala Ile Lys Asp Ala Ser Gly Ile Thr Cys Gly Gly Ile 
        355                 360                 365             


Tyr Ile Gly Gly Cys Trp Ile Leu Thr Ala Ala His Cys Leu Arg Ala 
    370                 375                 380                 


Ser Lys Thr His Arg Tyr Gln Ile Trp Thr Thr Val Val Asp Trp Ile 
385                 390                 395                 400 


His Pro Asp Leu Lys Arg Ile Val Ile Glu Tyr Val Asp Arg Ile Ile 
                405                 410                 415     


Phe His Glu Asn Tyr Asn Ala Gly Thr Tyr Gln Asn Asp Ile Ala Leu 
            420                 425                 430         


Ile Glu Met Lys Lys Asp Gly Asn Lys Lys Asp Cys Glu Leu Pro Arg 
        435                 440                 445             


Ser Ile Pro Ala Cys Val Pro Trp Ser Pro Tyr Leu Phe Gln Pro Asn 
    450                 455                 460                 


Asp Thr Cys Ile Val Ser Gly Trp Gly Arg Glu Lys Asp Asn Glu Arg 
465                 470                 475                 480 


Val Phe Ser Leu Gln Trp Gly Glu Val Lys Leu Ile Ser Asn Cys Ser 
                485                 490                 495     


Lys Phe Tyr Gly Asn Arg Phe Tyr Glu Lys Glu Met Glu Cys Ala Gly 
            500                 505                 510         


Thr Tyr Asp Gly Ser Ile Asp Ala Cys Lys Gly Asp Ser Gly Gly Pro 
        515                 520                 525             


Leu Val Cys Met Asp Ala Asn Asn Val Thr Tyr Val Trp Gly Val Val 
    530                 535                 540                 


Ser Trp Gly Glu Asn Cys Gly Lys Pro Glu Phe Pro Gly Val Tyr Thr 
545                 550                 555                 560 


Lys Val Ala Asn Tyr Phe Asp Trp Ile Ser Tyr His Val Gly Arg Pro 
                565                 570                 575     


Phe Ile Ser Gln Tyr Asn Val 
            580             

<210>  1974
<211>  1336
<212>  DNA
<213>  Homo sapiens

<400>  1974
ggtttcagtt acggtaaatc tctctggatt tcagccaaat tctttcagag ttcaaaagta     60

caaagctctt taggaggttt gttcttttga aacatttttt cagaggttaa aaattaaatt    120

tcaaaagaat acctggagtg gaaaagagtt ctcagcagag acaaagaccc cgaacacctc    180

caacatgaag cttcttcatg ttttcctgtt atttctgtgc ttccacttaa ggttttgcaa    240

ggtcacttat acatctcaag aggatctggt ggagaaaaag tgcttagcaa aaaaatatac    300

tcacctctcc tgcgataaag tcttctgcca gccatggcag agatgcattg agggcacctg    360

tgtttgtaaa ctaccgtatc agtgcccaaa gaatggcact gcagtgtgtg caactaacag    420

gagaagcttc ccaacatact gtcaacaaaa gagtttggaa tgtcttcatc cagggacaaa    480

gtttttaaat aacggaacat gcacagccga aggaaagttt agtgtttcct tgaagcatgg    540

aaatacagat tcagagggaa tagttgaagt aaaacttgtg gaccaagata agacaatgtt    600

catatgcaaa agcagctgga gcatgaggga agccaacgtg gcctgccttg accttgggtt    660

tcaacaaggt gctgatactc aaagaaggtt taagttgtct gatctctcta taaattccac    720

tgaatgtcta catgtgcatt gccgaggatt agagaccagt ttggctgaat gtacttttac    780

taagagaaga actatgggtt accaggattt cgctgatgtg gtttgttata cacagaaagc    840

agattctcca atggatgact tctttcagtg tgtgaatggg aaatacattt ctcagatgaa    900

agcctgtgat ggtatcaatg attgtggaga ccaaagtgat gaactgtgtt gtaaagcatg    960

ccaaggcaaa ggcttccatt gcaaatcggg tgtttgcatt ccaagccagt atcaatgcaa   1020

tggtgaggtg gactgcatta caggggaaga tgaagttggc tgtgcaggct ttgcatctgt   1080

gactcaagaa gaaacagaaa ttttgactgc tgacatggat gcagaaagaa gacggataaa   1140

atcattatta cctaaactat cttgtggagt taaaaacaga atgcacattc gaaggaaacg   1200

aattgtggga ggaaagcgag cacaactggg gggaaaaatg aagcaaatct cactggatat   1260

ttttaaaggt ctccacagag tttatgccat attggaattt tgttgtataa ttctcaaata   1320

aatattttgg tgaagc                                                   1336


<210>  1975
<211>  378
<212>  PRT
<213>  Homo sapiens

<400>  1975


Met Lys Leu Leu His Val Phe Leu Leu Phe Leu Cys Phe His Leu Arg 
1               5                   10                  15      


Phe Cys Lys Val Thr Tyr Thr Ser Gln Glu Asp Leu Val Glu Lys Lys 
            20                  25                  30          


Cys Leu Ala Lys Lys Tyr Thr His Leu Ser Cys Asp Lys Val Phe Cys 
        35                  40                  45              


Gln Pro Trp Gln Arg Cys Ile Glu Gly Thr Cys Val Cys Lys Leu Pro 
    50                  55                  60                  


Tyr Gln Cys Pro Lys Asn Gly Thr Ala Val Cys Ala Thr Asn Arg Arg 
65                  70                  75                  80  


Ser Phe Pro Thr Tyr Cys Gln Gln Lys Ser Leu Glu Cys Leu His Pro 
                85                  90                  95      


Gly Thr Lys Phe Leu Asn Asn Gly Thr Cys Thr Ala Glu Gly Lys Phe 
            100                 105                 110         


Ser Val Ser Leu Lys His Gly Asn Thr Asp Ser Glu Gly Ile Val Glu 
        115                 120                 125             


Val Lys Leu Val Asp Gln Asp Lys Thr Met Phe Ile Cys Lys Ser Ser 
    130                 135                 140                 


Trp Ser Met Arg Glu Ala Asn Val Ala Cys Leu Asp Leu Gly Phe Gln 
145                 150                 155                 160 


Gln Gly Ala Asp Thr Gln Arg Arg Phe Lys Leu Ser Asp Leu Ser Ile 
                165                 170                 175     


Asn Ser Thr Glu Cys Leu His Val His Cys Arg Gly Leu Glu Thr Ser 
            180                 185                 190         


Leu Ala Glu Cys Thr Phe Thr Lys Arg Arg Thr Met Gly Tyr Gln Asp 
        195                 200                 205             


Phe Ala Asp Val Val Cys Tyr Thr Gln Lys Ala Asp Ser Pro Met Asp 
    210                 215                 220                 


Asp Phe Phe Gln Cys Val Asn Gly Lys Tyr Ile Ser Gln Met Lys Ala 
225                 230                 235                 240 


Cys Asp Gly Ile Asn Asp Cys Gly Asp Gln Ser Asp Glu Leu Cys Cys 
                245                 250                 255     


Lys Ala Cys Gln Gly Lys Gly Phe His Cys Lys Ser Gly Val Cys Ile 
            260                 265                 270         


Pro Ser Gln Tyr Gln Cys Asn Gly Glu Val Asp Cys Ile Thr Gly Glu 
        275                 280                 285             


Asp Glu Val Gly Cys Ala Gly Phe Ala Ser Val Thr Gln Glu Glu Thr 
    290                 295                 300                 


Glu Ile Leu Thr Ala Asp Met Asp Ala Glu Arg Arg Arg Ile Lys Ser 
305                 310                 315                 320 


Leu Leu Pro Lys Leu Ser Cys Gly Val Lys Asn Arg Met His Ile Arg 
                325                 330                 335     


Arg Lys Arg Ile Val Gly Gly Lys Arg Ala Gln Leu Gly Gly Lys Met 
            340                 345                 350         


Lys Gln Ile Ser Leu Asp Ile Phe Lys Gly Leu His Arg Val Tyr Ala 
        355                 360                 365             


Ile Leu Glu Phe Cys Cys Ile Ile Leu Lys 
    370                 375             

<210>  1976
<211>  1463
<212>  DNA
<213>  Homo sapiens

<400>  1976
ggtttcagtt acggtaaatc tctctggatt tcagccaaat tctttcagag ttcaaaagta     60

caaagctctt taggaggttt gttcttttga aacatttttt cagaggttaa aaattaaatt    120

tcaaaagaat acctggagtg gaaaagagtt ctcagcagag acaaagaccc cgaacacctc    180

caacatgaag cttcttcatg ttttcctgtt atttctgtgc ttccacttaa ggttttgcaa    240

ggtcacttat acatctcaag aggatctggt ggagaaaaag tgcttagcaa aaaaatatac    300

tcacctctcc tgcgataaag tcttctgcca gccatggcag agatgcattg agggcacctg    360

tgtttgtaaa ctaccgtatc agtgcccaaa gaatggcact gcagtgtgtg caactaacag    420

gagaagcttc ccaacatact gtcaacaaaa gagtttggaa tgtcttcatc cagggacaaa    480

gtttttaaat aacggaacat gcacagccga aggaaagttt agtgtttcct tgaagcatgg    540

aaatacagat tcagagggaa tagttgaagt aaaacttgtg gaccaagata agacaatgtt    600

catatgcaaa agcagctgga gcatgaggga agccaacgtg gcctgccttg accttgggtt    660

tcaacaaggt gctgatactc aaagaaggtt taagttgtct gatctctcta taaattccac    720

tgaatgtcta catgtgcatt gccgaggatt agagaccagt ttggctgaat gtacttttac    780

taagagaaga actatgggtt accaggattt cgctgatgtg gtttgttata cacagaaagc    840

agattctcca atggatgact tctttcagtg tgtgaatggg aaatacattt ctcagatgaa    900

agcctgtgat ggtatcaatg attgtggaga ccaaagtgat gaactgtgtt gtaaagcatg    960

ccaaggcaaa ggcttccatt gcaaatcggg tgtttgcatt ccaagccagt atcaatgcaa   1020

tggtgaggtg gactgcatta caggggaaga tgaagttggc tgtgcaggct ttgcatctgt   1080

gactcaagaa gaaacagaaa ttttgactgc tgacatggat gcagaaagaa gacggataaa   1140

atcattatta cctaaactat cttgtggagt taaaaacaga atgcacattc gaaggaaacg   1200

aattgtggga ggaaagcgag cacaactggg agacctccca tggcaggtgg caattaagga   1260

tgccagtgga atcacctgtg ggggaattta tattggtggc tgttggattc tgactgctgc   1320

acattgtctc agagccagta aaactcatcg ttaccaaata tggacaacag tagtagactg   1380

gatacacccc gaccttaaac gtatagtaat tgaatacgtg gatagaatta ttttccatga   1440

aaactacaat gcaggcactt acc                                           1463


<210>  1977
<211>  425
<212>  PRT
<213>  Homo sapiens

<400>  1977


Met Lys Leu Leu His Val Phe Leu Leu Phe Leu Cys Phe His Leu Arg 
1               5                   10                  15      


Phe Cys Lys Val Thr Tyr Thr Ser Gln Glu Asp Leu Val Glu Lys Lys 
            20                  25                  30          


Cys Leu Ala Lys Lys Tyr Thr His Leu Ser Cys Asp Lys Val Phe Cys 
        35                  40                  45              


Gln Pro Trp Gln Arg Cys Ile Glu Gly Thr Cys Val Cys Lys Leu Pro 
    50                  55                  60                  


Tyr Gln Cys Pro Lys Asn Gly Thr Ala Val Cys Ala Thr Asn Arg Arg 
65                  70                  75                  80  


Ser Phe Pro Thr Tyr Cys Gln Gln Lys Ser Leu Glu Cys Leu His Pro 
                85                  90                  95      


Gly Thr Lys Phe Leu Asn Asn Gly Thr Cys Thr Ala Glu Gly Lys Phe 
            100                 105                 110         


Ser Val Ser Leu Lys His Gly Asn Thr Asp Ser Glu Gly Ile Val Glu 
        115                 120                 125             


Val Lys Leu Val Asp Gln Asp Lys Thr Met Phe Ile Cys Lys Ser Ser 
    130                 135                 140                 


Trp Ser Met Arg Glu Ala Asn Val Ala Cys Leu Asp Leu Gly Phe Gln 
145                 150                 155                 160 


Gln Gly Ala Asp Thr Gln Arg Arg Phe Lys Leu Ser Asp Leu Ser Ile 
                165                 170                 175     


Asn Ser Thr Glu Cys Leu His Val His Cys Arg Gly Leu Glu Thr Ser 
            180                 185                 190         


Leu Ala Glu Cys Thr Phe Thr Lys Arg Arg Thr Met Gly Tyr Gln Asp 
        195                 200                 205             


Phe Ala Asp Val Val Cys Tyr Thr Gln Lys Ala Asp Ser Pro Met Asp 
    210                 215                 220                 


Asp Phe Phe Gln Cys Val Asn Gly Lys Tyr Ile Ser Gln Met Lys Ala 
225                 230                 235                 240 


Cys Asp Gly Ile Asn Asp Cys Gly Asp Gln Ser Asp Glu Leu Cys Cys 
                245                 250                 255     


Lys Ala Cys Gln Gly Lys Gly Phe His Cys Lys Ser Gly Val Cys Ile 
            260                 265                 270         


Pro Ser Gln Tyr Gln Cys Asn Gly Glu Val Asp Cys Ile Thr Gly Glu 
        275                 280                 285             


Asp Glu Val Gly Cys Ala Gly Phe Ala Ser Val Thr Gln Glu Glu Thr 
    290                 295                 300                 


Glu Ile Leu Thr Ala Asp Met Asp Ala Glu Arg Arg Arg Ile Lys Ser 
305                 310                 315                 320 


Leu Leu Pro Lys Leu Ser Cys Gly Val Lys Asn Arg Met His Ile Arg 
                325                 330                 335     


Arg Lys Arg Ile Val Gly Gly Lys Arg Ala Gln Leu Gly Asp Leu Pro 
            340                 345                 350         


Trp Gln Val Ala Ile Lys Asp Ala Ser Gly Ile Thr Cys Gly Gly Ile 
        355                 360                 365             


Tyr Ile Gly Gly Cys Trp Ile Leu Thr Ala Ala His Cys Leu Arg Ala 
    370                 375                 380                 


Ser Lys Thr His Arg Tyr Gln Ile Trp Thr Thr Val Val Asp Trp Ile 
385                 390                 395                 400 


His Pro Asp Leu Lys Arg Ile Val Ile Glu Tyr Val Asp Arg Ile Ile 
                405                 410                 415     


Phe His Glu Asn Tyr Asn Ala Gly Thr 
            420                 425 

<210>  1978
<211>  1331
<212>  DNA
<213>  Homo sapiens

<400>  1978
ggtttcagtt acggtaaatc tctctggatt tcagccaaat tctttcagag ttcaaaagta     60

caaagctctt taggaggttt gttcttttga aacatttttt cagaggttaa aaattaaatt    120

tcaaaagaat acctggagtg gaaaagagtt ctcagcagag acaaagaccc cgaacacctc    180

caacatgaag cttcttcatg ttttcctgtt atttctgtgc ttccacttaa ggttttgcaa    240

ggtcacttat acatctcaag aggatctggt ggagaaaaag tgcttagcaa aaaaatatac    300

tcacctctcc tgcgataaag tcttctgcca gccatggcag agatgcattg agggcacctg    360

tgtttgtaaa ctaccgtatc agtgcccaaa gaatggcact gcagtgtgtg caactaacag    420

gagaagcttc ccaacatact gtcaacaaaa gagtttggaa tgtcttcatc cagggacaaa    480

gtttttaaat aacggaacat gcacagccga aggaaagttt agtgtttcct tgaagcatgg    540

aaatacagat tcagagggaa tagttgaagt aaaacttgtg gaccaagata agacaatgtt    600

catatgcaaa agcagctgga gcatgaggga agccaacgtg gcctgccttg accttgggtt    660

tcaacagtga gcgcttgtat cagtggattt tctcatggct gatttaattg ttctgtttgc    720

tttttgatta cctaaccttt ctgtgtatta atttccatat gtgtaaccta agaaaattaa    780

ctatgtgcat catagcattg ttatgaggat gatatgcatt catgtttacc caacacttgg    840

aaccctgctg acaacaaagc atggataata agtctgttga agtatctgga tgtgaatcct    900

ttagtgattc tgagagtcac aaacacattc atttctgtct gtctcctact cgtctacaat    960

tatgtacact ttttcacact tagtatagtt tatatactgt gtgtgagtat agtttatagt   1020

tatataatat agtttatact ataaactata cagtgagtat aaactataca gttatagtat   1080

aaactatata gttaggataa attatagttt atagttttat agtatagttt actataatta   1140

tagtatataa gtatatatac tatgagtata gtgtacaaac tataatttat atatagctta   1200

tatactataa ttatagtata tatacttata tataagtgat attttattta ttgtttggtt   1260

cagaatatct tctaactttc aatataattt cttctttgcc ccatatgtaa tttagaagtt   1320

ttctttatta t                                                        1331


<210>  1979
<211>  161
<212>  PRT
<213>  Homo sapiens

<400>  1979


Met Lys Leu Leu His Val Phe Leu Leu Phe Leu Cys Phe His Leu Arg 
1               5                   10                  15      


Phe Cys Lys Val Thr Tyr Thr Ser Gln Glu Asp Leu Val Glu Lys Lys 
            20                  25                  30          


Cys Leu Ala Lys Lys Tyr Thr His Leu Ser Cys Asp Lys Val Phe Cys 
        35                  40                  45              


Gln Pro Trp Gln Arg Cys Ile Glu Gly Thr Cys Val Cys Lys Leu Pro 
    50                  55                  60                  


Tyr Gln Cys Pro Lys Asn Gly Thr Ala Val Cys Ala Thr Asn Arg Arg 
65                  70                  75                  80  


Ser Phe Pro Thr Tyr Cys Gln Gln Lys Ser Leu Glu Cys Leu His Pro 
                85                  90                  95      


Gly Thr Lys Phe Leu Asn Asn Gly Thr Cys Thr Ala Glu Gly Lys Phe 
            100                 105                 110         


Ser Val Ser Leu Lys His Gly Asn Thr Asp Ser Glu Gly Ile Val Glu 
        115                 120                 125             


Val Lys Leu Val Asp Gln Asp Lys Thr Met Phe Ile Cys Lys Ser Ser 
    130                 135                 140                 


Trp Ser Met Arg Glu Ala Asn Val Ala Cys Leu Asp Leu Gly Phe Gln 
145                 150                 155                 160 


Gln 
    

<210>  1980
<211>  747
<212>  DNA
<213>  Homo sapiens

<400>  1980
tggagaaaat cgttttactt cgagtgacaa gatttttggg tttaaataaa tattgaatct     60

ttggaaaagt tatattgcaa aaagggatct tgaaatgttt ccactgctgc ttggacttta    120

gaataaggaa gtctcaagtc ttaccgaaaa ccaccgtggg gaattgcaga acaaaaccga    180

acaatatttt ccttcccctg gaacacaact gtataactac gtgaggaacc ctttccttga    240

atcttctcag cctgagcacc tggctttatt tgtgagagaa gctttggaga atgtggggga    300

agctgatgtc aaatataaag ggcttaaaga gagaagaggg agaggagctt tcagcacagt    360

ccagttcaca gcccgtcggt gctcaaaaca tacttgaata cctggtacaa aagataaaaa    420

tgatggtttg gttttctata agacagcata gtttctttaa aattacacac acacatgcat    480

tgcttttctt cctttaatta gttgagacca taggacaaaa gaagaggcat agttgagcgc    540

gtaatggtgc gaaaatcaaa aggttgggaa gaaacaagaa actcagataa acgcttccgt    600

cggctgtgac aggttctgag gcgcccagat ctactggaca tagcgcggct cagaagcctc    660

agagacctgt ccgcacagtt cctgaagtta gcaacaaatt agtgagtgct gttgcgggcc    720

attttgcagc cagagaagca aatgcgc                                        747


<210>  1981
<211>  68
<212>  PRT
<213>  Homo sapiens

<400>  1981


Met Trp Gly Lys Leu Met Ser Asn Ile Lys Gly Leu Lys Arg Glu Glu 
1               5                   10                  15      


Gly Glu Glu Leu Ser Ala Gln Ser Ser Ser Gln Pro Val Gly Ala Gln 
            20                  25                  30          


Asn Ile Leu Glu Tyr Leu Val Gln Lys Ile Lys Met Met Val Trp Phe 
        35                  40                  45              


Ser Ile Arg Gln His Ser Phe Phe Lys Ile Thr His Thr His Ala Leu 
    50                  55                  60                  


Leu Phe Phe Leu 
65              

<210>  1982
<211>  1270
<212>  DNA
<213>  Homo sapiens

<400>  1982
ccgctgttat acgtcacttc cacggctcag cgtcaggcaa gttggcctct ctgttgtaaa     60

ttagtggtta aggttatcta ttattgccac ttttccagcg ctaaaggctg ttttggaacc    120

agtgttgctt gttccgcggg tgattggctt ttttttttgg caaaccagtt attcaagttt    180

ctggtcttta aaaaactctg tggcggtacg gtaaccgagg aggttccagc gcggcggaag    240

taccccgcgg gtgggtgtgt gcgcaaggcc agggccagag gggcacgtgg cgccgggagg    300

agagagaatg tcttttcgag gcggaggtcg tggaggcttt aatcgaggtg gtggaggtgg    360

cggcttcaac cgaggtggca gcagcaacca cttccgaggt ggaggcggcg gtggaggcgg    420

cggcaatttc agaggcggcg gcaggggagg atttggacga gggggtggcc gcggaggctt    480

taacaaaggc caagaccaag gacctccaga acgtgtagtc ttattaggag agttcctgca    540

tccctgtgaa gatgacatag tttgtaaatg taccacagat gaaaataagg tgccttattt    600

caatgctcct gtttacttag aaaacaaaga acaaattgga aaagtggatg aaatatttgg    660

acaactcaga gatttttatt tttcagttaa gttgtcagaa aacatgaagg cttcatcctt    720

taaaaaacta cagaagtttt atatagaccc atataagctg ctgccactgc agaggttttt    780

acctcgacct ccaggtgaga aaggacctcc aagaggtggt ggcaggggag gccgaggagg    840

aggaagagga ggaggtggca gaggtggtgg cagaggcggt ggttttagag gtggaagagg    900

aggtggaggt gggggcttca gaggaggaag aggtggtggt ttcagaggga gaggacatta    960

agtgaaacag ttgacagaca tcaccagttg acttctgcat taacctgcat gatctgtttc   1020

tactatggat tggaaacttg tttcttgaac aagtcttgaa gatcttggtc attttatgac   1080

aatggatcta aaatgtcagc atcatgcaaa gtgcaacgga atagtgaatt ttgctctaaa   1140

agagcatgaa caagtctttc taatgttttg tacagtgcct ggcactctgt gggtgctcaa   1200

taaatggata ggagttttca tttgaagcat atttgaattt ttaaaataaa gtgttttatt   1260

cccttaagtt                                                          1270


<210>  1983
<211>  217
<212>  PRT
<213>  Homo sapiens

<400>  1983


Met Ser Phe Arg Gly Gly Gly Arg Gly Gly Phe Asn Arg Gly Gly Gly 
1               5                   10                  15      


Gly Gly Gly Phe Asn Arg Gly Gly Ser Ser Asn His Phe Arg Gly Gly 
            20                  25                  30          


Gly Gly Gly Gly Gly Gly Gly Asn Phe Arg Gly Gly Gly Arg Gly Gly 
        35                  40                  45              


Phe Gly Arg Gly Gly Gly Arg Gly Gly Phe Asn Lys Gly Gln Asp Gln 
    50                  55                  60                  


Gly Pro Pro Glu Arg Val Val Leu Leu Gly Glu Phe Leu His Pro Cys 
65                  70                  75                  80  


Glu Asp Asp Ile Val Cys Lys Cys Thr Thr Asp Glu Asn Lys Val Pro 
                85                  90                  95      


Tyr Phe Asn Ala Pro Val Tyr Leu Glu Asn Lys Glu Gln Ile Gly Lys 
            100                 105                 110         


Val Asp Glu Ile Phe Gly Gln Leu Arg Asp Phe Tyr Phe Ser Val Lys 
        115                 120                 125             


Leu Ser Glu Asn Met Lys Ala Ser Ser Phe Lys Lys Leu Gln Lys Phe 
    130                 135                 140                 


Tyr Ile Asp Pro Tyr Lys Leu Leu Pro Leu Gln Arg Phe Leu Pro Arg 
145                 150                 155                 160 


Pro Pro Gly Glu Lys Gly Pro Pro Arg Gly Gly Gly Arg Gly Gly Arg 
                165                 170                 175     


Gly Gly Gly Arg Gly Gly Gly Gly Arg Gly Gly Gly Arg Gly Gly Gly 
            180                 185                 190         


Phe Arg Gly Gly Arg Gly Gly Gly Gly Gly Gly Phe Arg Gly Gly Arg 
        195                 200                 205             


Gly Gly Gly Phe Arg Gly Arg Gly His 
    210                 215         

<210>  1984
<211>  840
<212>  DNA
<213>  Homo sapiens

<400>  1984
ccgctgttat acgtcacttc cacggctcag cgtcaggcaa gagagagaat gtcttttcga     60

ggcggaggtc gtggaggctt taatcgaatt tggacgaggg ggtggccgcg gaggctttaa    120

caaaggccaa gaccaaggac ctccagaacg tgtagtctta ttaggagagt tcctgcatcc    180

ctgtgaagat gacatagttt gtaaatgtac cacagatgaa aataaggtgc cttatttcaa    240

tgctcctgtt tacttagaaa acaaagaaca aattggaaaa gtggatgaaa tatttggaca    300

actcagagat ttttattttt cagttaagtt gtcagaaaac atgaaggctt catcctttaa    360

aaaactacag aagttttata tagacccata taagctgctg ccactgcaga ggtttttacc    420

tcgacctcca ggtgagaaag gacctccggt ggttttagag gtggaagagg aggtggaggt    480

gggggcttca gaggaggaag aggtggtggt ttcagaggga gaggacatta agtgaaacag    540

ttgacagaca tcaccagttg acttctgcat taacctgcat gatctgtttc tactatggat    600

tggaaacttg tttcttgaac aagtcttgaa gatcttggtc attttatgac aatggatcta    660

aaatgtcagc atcatgcaaa gtgcaacgga atagtgaatt ttgctctaaa agagcatgaa    720

caagtctttc taatgttttg tacagtgcct ggcactctgt gggtgctcaa taaatggata    780

ggagttttca tttgaagcat atttgaattt ttaaaataaa gtgttttatt cccttaagtt    840


<210>  1985
<211>  64
<212>  PRT
<213>  Homo sapiens

<400>  1985


Met Lys Ala Ser Ser Phe Lys Lys Leu Gln Lys Phe Tyr Ile Asp Pro 
1               5                   10                  15      


Tyr Lys Leu Leu Pro Leu Gln Arg Phe Leu Pro Arg Pro Pro Gly Glu 
            20                  25                  30          


Lys Gly Pro Pro Val Val Leu Glu Val Glu Glu Glu Val Glu Val Gly 
        35                  40                  45              


Ala Ser Glu Glu Glu Glu Val Val Val Ser Glu Gly Glu Asp Ile Lys 
    50                  55                  60                  

<210>  1986
<211>  527
<212>  DNA
<213>  Homo sapiens

<400>  1986
gcgtcaggca agttggcctc tctgttgtaa attagtggtt aaggttatct attattgcca     60

cttttccagc gctaaaggct gttttggaac cagtgttgct tgttccgcgg gtgattggct    120

tttttttttg gcaaaccagt tattcaagtt tctggtcttt aaaaaactct gtggcggtac    180

ggtaaccgag gaggttccag cgcggcggaa gtaccccgcg ggtgggtgtg tgcgcaaggc    240

cagggccaga ggggcacgtg gcgccgggag gagagagaat gtcttttcga ggcggaggtc    300

gtggaggctt taatcgaggt ggtggaggtg gcggcttcaa ccgaggtggc agcagcaacc    360

acttccgagg tggaggcggc ggtggaggcg gcggcaattt cagaggcggc ggcaggggag    420

gatttggacg agggggtggc cgcggaggct ttaacaaagg ccaagaccaa ggacctccag    480

aacgtgtagt ctgtatgcag tcttcagtat ttagcttatt tgaagga                  527


<210>  1987
<211>  82
<212>  PRT
<213>  Homo sapiens

<400>  1987


Met Ser Phe Arg Gly Gly Gly Arg Gly Gly Phe Asn Arg Gly Gly Gly 
1               5                   10                  15      


Gly Gly Gly Phe Asn Arg Gly Gly Ser Ser Asn His Phe Arg Gly Gly 
            20                  25                  30          


Gly Gly Gly Gly Gly Gly Gly Asn Phe Arg Gly Gly Gly Arg Gly Gly 
        35                  40                  45              


Phe Gly Arg Gly Gly Gly Arg Gly Gly Phe Asn Lys Gly Gln Asp Gln 
    50                  55                  60                  


Gly Pro Pro Glu Arg Val Val Cys Met Gln Ser Ser Val Phe Ser Leu 
65                  70                  75                  80  


Phe Glu 
        

<210>  1988
<211>  795
<212>  DNA
<213>  Homo sapiens

<400>  1988
ggctttaaca aaggccaaga ccaaggacct ccagaacgtg tagtcttatt aggagagttc     60

ctgcatccct gtgaagatga catagtttgt aaatgtacca cagatgaaaa taaggtgcct    120

tatttcaatg ctcctgttta cttagaaaac aaagaacaaa ttggaaaagt ggatgaaata    180

tttggacaac tcagagattt ttatttttca gttaagttgt cagaaaacat gaaggcttca    240

tcctttaaaa aactacagaa gttttatata gacccatata agctgctgcc actgcagagg    300

tttttacctc gacctccagg tgagaaagga cctccaagag gtggtggcag gggaggccga    360

ggaggaggaa gaggaggagg tggcagaggt ggtggcagag gcggtggttt tagaggtgga    420

agaggaggtg gaggtggggg cttcagagga ggaagaggtg gtggtttcag agggagagga    480

cattaagtga aacagttgac agacatcacc agttgacttc tgcattaacc tgcatgatct    540

gtttctacta tggattggaa acttgtttct tgaacaagtc ttgaagatct tggtcatttt    600

atgacaatgg atctaaaatg tcagcatcat gcaaagtgca acggaatagt gaattttgct    660

ctaaaagagc atgaacaagt ctttctaatg ttttgtacag tgcctggcac tctgtgggtg    720

ctcaataaat ggataggagt tttcatttga agcatatttg aatttttaaa ataaagtgtt    780

ttattccctt aagtt                                                     795


<210>  1989
<211>  85
<212>  PRT
<213>  Homo sapiens

<400>  1989


Met Lys Ala Ser Ser Phe Lys Lys Leu Gln Lys Phe Tyr Ile Asp Pro 
1               5                   10                  15      


Tyr Lys Leu Leu Pro Leu Gln Arg Phe Leu Pro Arg Pro Pro Gly Glu 
            20                  25                  30          


Lys Gly Pro Pro Arg Gly Gly Gly Arg Gly Gly Arg Gly Gly Gly Arg 
        35                  40                  45              


Gly Gly Gly Gly Arg Gly Gly Gly Arg Gly Gly Gly Phe Arg Gly Gly 
    50                  55                  60                  


Arg Gly Gly Gly Gly Gly Gly Phe Arg Gly Gly Arg Gly Gly Gly Phe 
65                  70                  75                  80  


Arg Gly Arg Gly His 
                85  

<210>  1990
<211>  496
<212>  DNA
<213>  Homo sapiens

<400>  1990
taggcttatc aatataagag gttatacagt taataactta atgattatta tattctattg     60

ttatttaaat actttgcgtt attatttaat aaatgttttt taggtggttt tagaggtgga    120

agaggaggtg gaggtggggg cttcagagga ggaagaggtg gtggtttcag agggagagga    180

cattaagtga aacagttgac agacatcacc agttgacttc tgcattaacc tgcatgatct    240

gtttctacta tggattggaa acttgtttct tgaacaagtc ttgaagatct tggtcatttt    300

atgacaatgg atctaaaatg tcagcatcat gcaaagtgca acggaatagt gaattttgct    360

ctaaaagagc atgaacaagt ctttctaatg ttttgtacag tgcctggcac tctgtgggtg    420

ctcaataaat ggataggagt tttcatttga agcatatttg aatttttaaa ataaagtgtt    480

ttattccctt aagtta                                                    496


<210>  1991
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  1991


Met Thr Met Asp Leu Lys Cys Gln His His Ala Lys Cys Asn Gly Ile 
1               5                   10                  15      


Val Asn Phe Ala Leu Lys Glu His Glu Gln Val Phe Leu Met Phe Cys 
            20                  25                  30          


Thr Val Pro Gly Thr Leu Trp Val Leu Asn Lys Trp Ile Gly Val Phe 
        35                  40                  45              


Ile 
    

<210>  1992
<211>  1610
<212>  DNA
<213>  Homo sapiens

<400>  1992
attatgaagg gtgtttcggt atcttccctc caaaatgcta agaaataatt taggcaacag     60

ttcagactct aaaaatgaag atggctcggt cttttcacag actgaacaca atattgttgc    120

aacttacttg attatggcag gtatgataag tattatcagc aacataatag ttctgggcat    180

cttcattaag tacaaggaac ttcggacacc cacaaatgca attattatta acctggctgt    240

tactgatata ggggtcagta gcattggcta tcccatgtct gctgcctcag atctgtatgg    300

aagttggaaa tttggatacg caggctgtca ggtttatgct ggattgaata ttttttttgg    360

aatggcaagc attggattac tcacggtcgt ggctgtggac cgatacctga ccatctgcct    420

tcctgacgta gggagaagaa tgaccaccaa cacttacatc ggcttgattc tgggagcctg    480

gatcaatggc ctgttttggg ctttgatgcc tatcataggg tgggctagtt atgccccaga    540

tcctactggt gctacgtgta ccataaactg gaggaaaaat gatagatctt ttgtgtctta    600

caccatgaca gttattgcga taaattttat tgtgcccttg acagtgatgt tttactgcta    660

ttaccatgtc acgctatcca ttaaacatca cactaccagt gactgcactg agtccctcaa    720

cagagactgg tcagatcaga tagatgtaac aaagatgtct gtgatcatga tctgcatgtt    780

tctggtggca tggtcccctt attccatcgt gtgcttatgg gcttcttttg gtgacccaaa    840

gaagattcct ccccccatgg ccatcatagc tccactgttt gcaaaatctt ctacattcta    900

taacccctgc atttatgtgg ttgctaataa aaagtttcgg agggcaatgc ttgccatgtt    960

caaatgtcag actcaccaaa caatgcctgt gacaagtatt ttacccatgg atgtatctca   1020

aaacccattg gcttctggaa gaatctgaaa taagataaaa ggacacacta tcaaaacact   1080

ttagtttttt gacaatgctt ttcttttaaa tatgagccca tttagatcaa gtgcagacat   1140

ggatcattgt cctatgagag tgtaagctcc tcaagcacag ctcgtgcttc tgtttgtgca   1200

ctctggctgc tgtagtgtat gcttctctgt gtcctgatat atcaacttat tgctcatctc   1260

ctttgatgaa ttaggcatca gaggttaagg tcccctttct ttctccctat tatggcatgc   1320

attacactgt actgatgacc tttaacttgc ctggctcctc cattagaata aaagcagtca   1380

ctaatttaat gttagaataa atgaataatt ctagataatt actgaaatga gttgttggat   1440

gttcccagtt agaatagaaa gcattttttg aatttcaaca ttttaacatt taaatcaatt   1500

aacttatgtt attaaacaaa aataaatgaa cattaaacat gattgtttct aaataaaatg   1560

ttaagtcaat gcatatatat tatatagcat tatgacccct gtgcatattt              1610


<210>  1993
<211>  337
<212>  PRT
<213>  Homo sapiens

<400>  1993


Met Leu Arg Asn Asn Leu Gly Asn Ser Ser Asp Ser Lys Asn Glu Asp 
1               5                   10                  15      


Gly Ser Val Phe Ser Gln Thr Glu His Asn Ile Val Ala Thr Tyr Leu 
            20                  25                  30          


Ile Met Ala Gly Met Ile Ser Ile Ile Ser Asn Ile Ile Val Leu Gly 
        35                  40                  45              


Ile Phe Ile Lys Tyr Lys Glu Leu Arg Thr Pro Thr Asn Ala Ile Ile 
    50                  55                  60                  


Ile Asn Leu Ala Val Thr Asp Ile Gly Val Ser Ser Ile Gly Tyr Pro 
65                  70                  75                  80  


Met Ser Ala Ala Ser Asp Leu Tyr Gly Ser Trp Lys Phe Gly Tyr Ala 
                85                  90                  95      


Gly Cys Gln Val Tyr Ala Gly Leu Asn Ile Phe Phe Gly Met Ala Ser 
            100                 105                 110         


Ile Gly Leu Leu Thr Val Val Ala Val Asp Arg Tyr Leu Thr Ile Cys 
        115                 120                 125             


Leu Pro Asp Val Gly Arg Arg Met Thr Thr Asn Thr Tyr Ile Gly Leu 
    130                 135                 140                 


Ile Leu Gly Ala Trp Ile Asn Gly Leu Phe Trp Ala Leu Met Pro Ile 
145                 150                 155                 160 


Ile Gly Trp Ala Ser Tyr Ala Pro Asp Pro Thr Gly Ala Thr Cys Thr 
                165                 170                 175     


Ile Asn Trp Arg Lys Asn Asp Arg Ser Phe Val Ser Tyr Thr Met Thr 
            180                 185                 190         


Val Ile Ala Ile Asn Phe Ile Val Pro Leu Thr Val Met Phe Tyr Cys 
        195                 200                 205             


Tyr Tyr His Val Thr Leu Ser Ile Lys His His Thr Thr Ser Asp Cys 
    210                 215                 220                 


Thr Glu Ser Leu Asn Arg Asp Trp Ser Asp Gln Ile Asp Val Thr Lys 
225                 230                 235                 240 


Met Ser Val Ile Met Ile Cys Met Phe Leu Val Ala Trp Ser Pro Tyr 
                245                 250                 255     


Ser Ile Val Cys Leu Trp Ala Ser Phe Gly Asp Pro Lys Lys Ile Pro 
            260                 265                 270         


Pro Pro Met Ala Ile Ile Ala Pro Leu Phe Ala Lys Ser Ser Thr Phe 
        275                 280                 285             


Tyr Asn Pro Cys Ile Tyr Val Val Ala Asn Lys Lys Phe Arg Arg Ala 
    290                 295                 300                 


Met Leu Ala Met Phe Lys Cys Gln Thr His Gln Thr Met Pro Val Thr 
305                 310                 315                 320 


Ser Ile Leu Pro Met Asp Val Ser Gln Asn Pro Leu Ala Ser Gly Arg 
                325                 330                 335     


Ile 
    

<210>  1994
<211>  375
<212>  DNA
<213>  Homo sapiens

<400>  1994
accttgatcc tgagccgtca tttctgccgt gataatcaca ggtgcactgt gaaggacaca     60

aacagcccac tccttccaaa aagctaagga caatgcacag acatgcaaag agatgcattg    120

ctccttttag aggttattta aacaaaaggt aaaaaccgaa tcctaagcat tcagaacctg    180

gtatgcatgg aagcaagacg tgccaaattg agcatagaaa cgactctcat aggacaatga    240

tccatgtctg cacttgatct aaatgggctc atatttaaaa gaaaagcatt gtcaaaaaac    300

taaagtgttt tgatagtgtg tccttttatc ttatttcaga ttcttccaga agccaatggg    360

ttttgagata catcc                                                     375


<210>  1995
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  1995


Lys Lys Ser Ile Val Lys Lys Leu Lys Cys Phe Asp Ser Val Ser Phe 
1               5                   10                  15      


Tyr Leu Ile Ser Asp Ser Ser Arg Ser Gln Trp Val Leu Arg Tyr 
            20                  25                  30      

<210>  1996
<211>  2448
<212>  DNA
<213>  Homo sapiens

<400>  1996
cttagacctt ggttagattt gaaccaaggc cctcctcggc ctcccaaagt gctgggatta     60

caggcgtgag ccactgccca gctgaaaatt gatacatttt tcaaatgaga agtatttttt    120

tcaaatgggt gttggaaagt gagtttcctc acattgttca tgttgtgaca ctaggttggt    180

gctatgtaat gacatggata tgaacgagct gcctacgaac ctccccgtgg acactgtgaa    240

gcttcgcata gagaagactg tcatccgcag aatctctgcg gaggccttct attacctggt    300

ggagctccag tatctctggg tgacttacaa ttccgtggcc agcattgacc ccagcagctt    360

ttacaacctg aagcaactgc atgagttgcg cttggatggg aattctctgg ctgctttccc    420

ttgggcatct ctgctggaca tgccccttct gaggaccctg gacttgcaca ataacaaaat    480

aaccagtgtg ccaaatgagg cgctcaggta tctgaagaac cttgcctact tggatttatc    540

aagcaacaga ctcaccacat tgccaccaga tttcctggag agctggactc atttagtttc    600

aacaccttct ggagtcctgg acctttcccc aagcaggatt attcttggtc tacaggacaa    660

tccttggttc tgtgactgtc atatttccaa aatgattgag ttgtcaaagg tcgttgaccc    720

tgctatagtg cttctggatc cactgatgac ttgcagtgaa cctgagcgcc tcacaggaat    780

tttgtttcag cgggctgaat tggagcattg tctgaaacca tcagtgatga cctcagccac    840

caaaatcatg tctgctctgg gcagtaatgt tctactgcgg tgtgatgcca ctggcttccc    900

caccccacag atcacatgga ccagatctga cagctcgcca gttaattata cagtaataca    960

agaatctcca gaggaaggag tcagatggtc cataatgagc ttgacaggca tttcttccaa   1020

agacgctggg gattacaaat gtaaggccaa aaatctggct gggatgtcag aagctgtggt   1080

tactgtgaca gtgcttggca ttaccacaac tccaatacca ccagacactt ctgaaagaac   1140

tggagatcat cctgagtggg atgtccagcc gggatctgga agatctacat ctgtatctag   1200

cgcatcatca tatctttgga accacaactc tgagcacaag catctcagca agtaccacca   1260

tggccaacaa gcgatcattc cagctccacc aaggtgggaa aagaaattta aaggtggcaa   1320

agaatggaag taagcttcct ccagccagca caagtaagaa agaagagctg gcattgttgg   1380

atcaaacaat gcttacggag acaaatgccg caatagaaaa cctcagggtg gtcagtgaga   1440

ctaaagagag tgtgacattg acgtggaata tgatcaacac cacacataac tctgcagtga   1500

ctgtgttgta ttccaagtat ggtgggaagg acctgctgct gttgaatgca gactccagca   1560

agaaccaagt aaccatagat ggcttggaac ccggtgggca atacatggcc tgtgtctgtc   1620

caaaaggagt gcctccccag aaagaccaat gcatcacctt ttctactgaa agagttgaag   1680

gagatgattc tcaatggtct ctccttctcg tggtgaccag tactgcctgt gttgttatct   1740

taccattgat ttgtttcttg ttgtacaaag tttgcaaact gcaatgtaaa tcagaacctt   1800

tttgggaaga tgatttggca aaggagactt atatccaatt tgagaccctg tttcccaggt   1860

ctcaaagtgt aggtgagctc tggacacgaa gccacaggga tgactcagag aaattgctgc   1920

tttgttctag gtcaagtgtg gaatctcagg tgacttttaa aagtgaaggt tccagaccag   1980

agtattattg ctaaggttct gcagctcagg tgcatgtgag ctacaaaact agcatctaag   2040

ggtataattg accctaggtt tggatgactt ttggacagac tttcacattg tacatgaaaa   2100

tcacaaatgg aatgctttta agtatgttta aaaaatacca tgagacctct gaactgaaaa   2160

gacaaataat gttgattttt tttcttgtgt ggaaaaggtc tacagaaata atttttagag   2220

tggtgcttaa taaattatta atacttttta gggtaatgtt ttagttctta aaaataagtt   2280

catgtgaaag tagcaagtga actctgtatt taaaaatata gttttttgag tcatgaggaa   2340

acattagcaa aaccagctaa gccttgatgt ttattcatgt tcgaagtgca ttatagcatt   2400

tgctgtggat gttttctgac attgcctaat ggagagcgtg ggatcata                2448


<210>  1997
<211>  379
<212>  PRT
<213>  Homo sapiens

<400>  1997


Met Asp Met Asn Glu Leu Pro Thr Asn Leu Pro Val Asp Thr Val Lys 
1               5                   10                  15      


Leu Arg Ile Glu Lys Thr Val Ile Arg Arg Ile Ser Ala Glu Ala Phe 
            20                  25                  30          


Tyr Tyr Leu Val Glu Leu Gln Tyr Leu Trp Val Thr Tyr Asn Ser Val 
        35                  40                  45              


Ala Ser Ile Asp Pro Ser Ser Phe Tyr Asn Leu Lys Gln Leu His Glu 
    50                  55                  60                  


Leu Arg Leu Asp Gly Asn Ser Leu Ala Ala Phe Pro Trp Ala Ser Leu 
65                  70                  75                  80  


Leu Asp Met Pro Leu Leu Arg Thr Leu Asp Leu His Asn Asn Lys Ile 
                85                  90                  95      


Thr Ser Val Pro Asn Glu Ala Leu Arg Tyr Leu Lys Asn Leu Ala Tyr 
            100                 105                 110         


Leu Asp Leu Ser Ser Asn Arg Leu Thr Thr Leu Pro Pro Asp Phe Leu 
        115                 120                 125             


Glu Ser Trp Thr His Leu Val Ser Thr Pro Ser Gly Val Leu Asp Leu 
    130                 135                 140                 


Ser Pro Ser Arg Ile Ile Leu Gly Leu Gln Asp Asn Pro Trp Phe Cys 
145                 150                 155                 160 


Asp Cys His Ile Ser Lys Met Ile Glu Leu Ser Lys Val Val Asp Pro 
                165                 170                 175     


Ala Ile Val Leu Leu Asp Pro Leu Met Thr Cys Ser Glu Pro Glu Arg 
            180                 185                 190         


Leu Thr Gly Ile Leu Phe Gln Arg Ala Glu Leu Glu His Cys Leu Lys 
        195                 200                 205             


Pro Ser Val Met Thr Ser Ala Thr Lys Ile Met Ser Ala Leu Gly Ser 
    210                 215                 220                 


Asn Val Leu Leu Arg Cys Asp Ala Thr Gly Phe Pro Thr Pro Gln Ile 
225                 230                 235                 240 


Thr Trp Thr Arg Ser Asp Ser Ser Pro Val Asn Tyr Thr Val Ile Gln 
                245                 250                 255     


Glu Ser Pro Glu Glu Gly Val Arg Trp Ser Ile Met Ser Leu Thr Gly 
            260                 265                 270         


Ile Ser Ser Lys Asp Ala Gly Asp Tyr Lys Cys Lys Ala Lys Asn Leu 
        275                 280                 285             


Ala Gly Met Ser Glu Ala Val Val Thr Val Thr Val Leu Gly Ile Thr 
    290                 295                 300                 


Thr Thr Pro Ile Pro Pro Asp Thr Ser Glu Arg Thr Gly Asp His Pro 
305                 310                 315                 320 


Glu Trp Asp Val Gln Pro Gly Ser Gly Arg Ser Thr Ser Val Ser Ser 
                325                 330                 335     


Ala Ser Ser Tyr Leu Trp Asn His Asn Ser Glu His Lys His Leu Ser 
            340                 345                 350         


Lys Tyr His His Gly Gln Gln Ala Ile Ile Pro Ala Pro Pro Arg Trp 
        355                 360                 365             


Glu Lys Lys Phe Lys Gly Gly Lys Glu Trp Lys 
    370                 375                 

<210>  1998
<211>  3780
<212>  DNA
<213>  Homo sapiens

<400>  1998
cttagacctt ggttagattt gaaccaaggc cctcctcggc ctcccaaagt gctgggatta     60

caggcgtgag ccactgccca gctgaaaatt gatacatttt tcaaatgaga agtatttttt    120

tcaaatgggt gttggaaagt gagtttcctc acattgttca tgttgtgaca ctaggttggt    180

gctatgtaat gacatggata tgaacgagct gcctacgaac ctccccgtgg acactgtgaa    240

gcttcgcata gagaagactg tcatccgcag aatctctgcg gaggccttct attacctggt    300

ggagctccag tatctctggg tgacttacaa ttccgtggcc agcattgacc ccagcagctt    360

ttacaacctg aagcaactgc atgagttgcg cttggatggg aattctctgg ctgctttccc    420

ttgggcatct ctgctggaca tgccccttct gaggaccctg gacttgcaca ataacaaaat    480

aaccagtgtg ccaaatgagg cgctcaggta tctgaagaac cttgcctact tggatttatc    540

aagcaacaga ctcaccacat tgccaccaga tttcctggag agctggactc atttagtttc    600

aacaccttct ggagtcctgg acctttcccc aagcaggatt attcttggct gatagaacgt    660

tacggctgta aaaagctcta gcatttatct agtcaactct cccattttgc cgatgagaaa    720

acaggctcag caaggttgca tcacccaggt cacagaatta actaatggtt gagcctcatc    780

aggaacccag gcacagtaaa gttggtctac aggacaatcc ttggttctgt gactgtcata    840

tttccaaaat gattgagttg tcaaaggtcg ttgaccctgc tatagtgctt ctggatccac    900

tgatgacttg cagtgaacct gagcgcctca caggaatttt gtttcagcgg gctgaattgg    960

agcattgtct gaaaccatca gtgatgacct cagccaccaa aatcatgtct gctctgggca   1020

gtaatgttct actgcggtgt gatgccactg gcttccccac cccacagatc acatggacca   1080

gatctgacag ctcgccagtt aattatacag taatacaaga atctccagag gaaggagtca   1140

gatggtccat aatgagcttg acaggcattt cttccaaaga cgctggggat tacaaatgta   1200

aggccaaaaa tctggctggg atgtcagaag ctgtggttac tgtgacagtg cttggcatta   1260

ccacaactcc aataccacca gacacttctg aaagaactgg agatcatcct gagtgggatg   1320

tccagccggg atctggaaga tctacatctg tatctagcgc atcatcatat ctttggtcct   1380

cttccttctc ccccacatct tctttttctg cttctacttt gtctcctccc tctactgctt   1440

ccttctcttt atctcctttc tcctcctcca ctgtttcttc aaccacaact ctgagcacaa   1500

gcatctcagc aagtaccacc atggccaaca agcgatcatt ccagctccac caaggtggga   1560

aaagaaattt aaaggtggca aagaatggaa gtaagcttcc tccagccagc acaagtaaga   1620

aagaagagct ggcattgttg gatcaaacaa tgcttacgga gacaaatgcc gcaatagaaa   1680

acctcagggt ggtcagtgag actaaagaga gtgtgacatt gacgtggaat atgatcaaca   1740

ccacacataa ctctgcagtg actgtgttgt attccaagta tggtgggaag gacctgctgc   1800

tgttgaatgc agactccagc aagaaccaag taaccataga tggcttggaa cccggtgggc   1860

aatacatggc ctgtgtctgt ccaaaaggag tgcctcccca gaaagaccaa tgcatcacct   1920

tttctactga aagagttgaa ggagatgatt ctcaatggtc tctccttctc gtggtgacca   1980

gtactgcctg tgttgttatc ttaccattga tttgtttctt gttgtacaaa gtttgcaaac   2040

tgcaatgtaa atcagaacct ttttgggaag atgatttggc aaaggagact tatatccaat   2100

ttgagaccct gtttcccagg tctcaaagtg taggtgagct ctggacacga agccacaggg   2160

atgactcaga gaaattgctg ctttgttcta ggtcaagtgt ggaatctcag gtgactttta   2220

aaagtgaagg ttccagacca gagtattatt gctaaggttc tgcagctcag gtgcatgtga   2280

gctacaaaac tagcatctaa gggtataatt gaccctaggt ttggatgact tttggacaga   2340

ctttcacatt gtacatgaaa atcacaaatg gaatgctttt aagtatgttt aaaaaatacc   2400

atgagacctc tgaactgaaa agacaaataa tgttgatttt ttttcttgtg tggaaaaggt   2460

ctacagaaat aatttttaga gtggtgctta ataaattatt aatacttttt agggtaatgt   2520

tttagttctt aaaaataagt tcatgtgaaa gtagcaagtg aactctgtat ttaaaaatat   2580

agttttttga gtcatgagga aacattagca aaaccagcta agccttgatg tttattcatg   2640

ttcgaagtgc attatagcat ttgctgtgga tgttttctga cattgcctaa tggagagcgt   2700

gggatcataa aggattttgt gttcactaag gttaaatcta actcacggga gagagagggc   2760

tctgtctctt ggtaccatta tgcattgtga tactatagag ttgtgttcat atttcttgta   2820

agaaaaattt ttgcttttct ttagaaatat aggtattagc aaaagtaagt atacaaagag   2880

gattatgaca aatagaccat ttctttaaaa atggtaactg ttgcatttaa acacatcgac   2940

tgacagatta tatggatatt taaaaataac tttaaatcaa tcttttaata ttttgctgtt   3000

tgctcttatg ttctcccttc tttcttcctt ccttgtcttc cctccctttc cttccttcat   3060

tctttctttc ttctgctctg tcagaagata tacaagtagc caaagcatca cgagccaagc   3120

tgtttgtctt ttgccatatt gtcttttgat tctcttgata aagagaaagc ttttgaaatt   3180

acttactgcc ctttgaaagt ctgttttaca accccaaagg atattttagg actttaaaag   3240

ggaagcttca gtggattcat ttggttagat tcttttccta ggttaaaaac atcggggaac   3300

ttaaatacat aggaaaggag ttcacaaata aaatttagtt tttttagaaa gagaatattt   3360

taataactgt agtatactac aagaaacatc tcatggcttt aagattaacg atagcgataa   3420

ggcccactca agcatctcac agtggtgata ttacatgtca cttagcagga tgcaacctgg   3480

cctagggatt tccagaagac aaggccacct cagcacagat gcaactttca taaattttag   3540

aacaaagcct aaccttacta gattaaactt gctctatgaa agaaacactt ggtaattgac   3600

ccagactgaa tacatgtata agaaatggga aagatctccc aaactctgag aacggtcctc   3660

aaatagaagc tctcctagtc agttggtcat ctgacctctg actatatccg gcctatgaca   3720

ccagccagct cctgctttct gtcttgtaag agcactgctg gaataaacta cttgagcatt   3780


<210>  1999
<211>  496
<212>  PRT
<213>  Homo sapiens

<400>  1999


Met Val Glu Pro His Gln Glu Pro Arg His Ser Lys Val Gly Leu Gln 
1               5                   10                  15      


Asp Asn Pro Trp Phe Cys Asp Cys His Ile Ser Lys Met Ile Glu Leu 
            20                  25                  30          


Ser Lys Val Val Asp Pro Ala Ile Val Leu Leu Asp Pro Leu Met Thr 
        35                  40                  45              


Cys Ser Glu Pro Glu Arg Leu Thr Gly Ile Leu Phe Gln Arg Ala Glu 
    50                  55                  60                  


Leu Glu His Cys Leu Lys Pro Ser Val Met Thr Ser Ala Thr Lys Ile 
65                  70                  75                  80  


Met Ser Ala Leu Gly Ser Asn Val Leu Leu Arg Cys Asp Ala Thr Gly 
                85                  90                  95      


Phe Pro Thr Pro Gln Ile Thr Trp Thr Arg Ser Asp Ser Ser Pro Val 
            100                 105                 110         


Asn Tyr Thr Val Ile Gln Glu Ser Pro Glu Glu Gly Val Arg Trp Ser 
        115                 120                 125             


Ile Met Ser Leu Thr Gly Ile Ser Ser Lys Asp Ala Gly Asp Tyr Lys 
    130                 135                 140                 


Cys Lys Ala Lys Asn Leu Ala Gly Met Ser Glu Ala Val Val Thr Val 
145                 150                 155                 160 


Thr Val Leu Gly Ile Thr Thr Thr Pro Ile Pro Pro Asp Thr Ser Glu 
                165                 170                 175     


Arg Thr Gly Asp His Pro Glu Trp Asp Val Gln Pro Gly Ser Gly Arg 
            180                 185                 190         


Ser Thr Ser Val Ser Ser Ala Ser Ser Tyr Leu Trp Ser Ser Ser Phe 
        195                 200                 205             


Ser Pro Thr Ser Ser Phe Ser Ala Ser Thr Leu Ser Pro Pro Ser Thr 
    210                 215                 220                 


Ala Ser Phe Ser Leu Ser Pro Phe Ser Ser Ser Thr Val Ser Ser Thr 
225                 230                 235                 240 


Thr Thr Leu Ser Thr Ser Ile Ser Ala Ser Thr Thr Met Ala Asn Lys 
                245                 250                 255     


Arg Ser Phe Gln Leu His Gln Gly Gly Lys Arg Asn Leu Lys Val Ala 
            260                 265                 270         


Lys Asn Gly Ser Lys Leu Pro Pro Ala Ser Thr Ser Lys Lys Glu Glu 
        275                 280                 285             


Leu Ala Leu Leu Asp Gln Thr Met Leu Thr Glu Thr Asn Ala Ala Ile 
    290                 295                 300                 


Glu Asn Leu Arg Val Val Ser Glu Thr Lys Glu Ser Val Thr Leu Thr 
305                 310                 315                 320 


Trp Asn Met Ile Asn Thr Thr His Asn Ser Ala Val Thr Val Leu Tyr 
                325                 330                 335     


Ser Lys Tyr Gly Gly Lys Asp Leu Leu Leu Leu Asn Ala Asp Ser Ser 
            340                 345                 350         


Lys Asn Gln Val Thr Ile Asp Gly Leu Glu Pro Gly Gly Gln Tyr Met 
        355                 360                 365             


Ala Cys Val Cys Pro Lys Gly Val Pro Pro Gln Lys Asp Gln Cys Ile 
    370                 375                 380                 


Thr Phe Ser Thr Glu Arg Val Glu Gly Asp Asp Ser Gln Trp Ser Leu 
385                 390                 395                 400 


Leu Leu Val Val Thr Ser Thr Ala Cys Val Val Ile Leu Pro Leu Ile 
                405                 410                 415     


Cys Phe Leu Leu Tyr Lys Val Cys Lys Leu Gln Cys Lys Ser Glu Pro 
            420                 425                 430         


Phe Trp Glu Asp Asp Leu Ala Lys Glu Thr Tyr Ile Gln Phe Glu Thr 
        435                 440                 445             


Leu Phe Pro Arg Ser Gln Ser Val Gly Glu Leu Trp Thr Arg Ser His 
    450                 455                 460                 


Arg Asp Asp Ser Glu Lys Leu Leu Leu Cys Ser Arg Ser Ser Val Glu 
465                 470                 475                 480 


Ser Gln Val Thr Phe Lys Ser Glu Gly Ser Arg Pro Glu Tyr Tyr Cys 
                485                 490                 495     

<210>  2000
<211>  4894
<212>  DNA
<213>  Homo sapiens

<400>  2000
caaaaagaga aactgttggg agaggaatcg tatctccata tttcttcttt cagccccaat     60

ccaagggttg tagctggaac tttccatcag ttcttccttt ctttttcctc tctaagcctt    120

tgccttgctc tgtcacagtg aagtcagcca gagcagggct gttaaactct gtgaaatttg    180

tcataagggt gtcaggtatt tcttactggc ttccaaagaa acatagataa agaaatcttt    240

cctgtggctt cccttggcag gctgcattca gaaggtctct cagttgaaga aagagcttgg    300

aggacaacag cacaacagga gagtaaaaga tgccccaggg ctgaggcctc cgctcaggca    360

gccgcatctg gggtcaatca tactcacctt gcccgggcca tgctccagca aaatcaagct    420

gttttctttt gaaagttcaa actcatcaag attatgctgc tcactcttat cattctgttg    480

ccagtagttt caaaatttag ttttgttagt ctctcagcac cgcagcactg gagctgtcct    540

gaaggtactc tcgcaggaaa tgggaattct acttgtgtgg gtcctgcacc cttcttaatt    600

ttctcccatg gaaatagtat ctttaggatt gacacagaag gaaccaatta tgagcaattg    660

gtggtggatg ctggtgtctc agtgatcatg gattttcatt ataatgagaa aagaatctat    720

tgggtggatt tagaaagaca acttttgcaa agagtttttc tgaatgggtc aaggcaagag    780

agagtatgta atatagagaa aaatgtttct ggaatggcaa taaattggat aaatgaagaa    840

gttatttggt caaatcaaca ggaaggaatc attacagtaa cagatatgaa aggaaataat    900

tcccacattc ttttaagtgc tttaaaatat cctgcaaatg tagcagttga tccagtagaa    960

aggtttatat tttggtcttc agaggtggct ggaagccttt atagagcaga tctcgatggt   1020

gtgggagtga aggctctgtt ggagacatca gagaaaataa cagctgtgtc attggatgtg   1080

cttgataagc ggctgttttg gattcagtac aacagagaag gaagcaattc tcttatttgc   1140

tcctgtgatt atgatggagg ttctgtccac attagtaaac atccaacaca gcataatttg   1200

tttgcaatgt ccctttttgg tgaccgtatc ttctattcaa catggaaaat gaagacaatt   1260

tggatagcca acaaacacac tggaaaggac atggttagaa ttaacctcca ttcatcattt   1320

gtaccacttg gtgaactgaa agtagtgcat ccacttgcac aacccaaggc agaagatgac   1380

acttgggagc ctgagcagaa actttgcaaa ttgaggaaag gaaactgcag cagcactgtg   1440

tgtgggcaag acctccagtc acacttgtgc atgtgtgcag agggatacgc cctaagtcga   1500

gaccggaagt actgtgaaga tgttaatgaa tgtgcttttt ggaatcatgg ctgtactctt   1560

gggtgtaaaa acacccctgg atcctattac tgcacgtgcc ctgtaggatt tgttctgctt   1620

cctgatggga aacgatgtca tcaacttgtt tcctgtccac gcaatgtgtc tgaatgcagc   1680

catgactgtg ttctgacatc agaaggtccc ttatgtttct gtcctgaagg ctcagtgctt   1740

gagagagatg ggaaaacatg tagcggttgt tcctcacccg ataatggtgg atgtagccag   1800

ctctgcgttc ctcttagccc agtatcctgg gaatgtgatt gctttcctgg gtatgaccta   1860

caactggatg aaaaaagctg tgcagcttca ggaccacaac catttttgct gtttgccaat   1920

tctcaagata ttcgacacat gcattttgat ggaacagact atggaactct gctcagccag   1980

cagatgggaa tggtttatgc cctagatcat gaccctgtgg aaaataagat atactttgcc   2040

catacagccc tgaagtggat agagagagct aatatggatg gttcccagcg agaaaggctt   2100

attgaggaag gagtagatgt gccagaaggt cttgctgtgg actggattgg ccgtagattc   2160

tattggacag acagagggaa atctctgatt ggaaggagtg atttaaatgg gaaacgttcc   2220

aaaataatca ctaaggagaa catctctcaa ccacgaggaa ttgctgttca tccaatggcc   2280

aagagattat tctggactga tacagggatt aatccacgaa ttgaaagttc ttccctccaa   2340

ggccttggcc gtctggttat agccagctct gatctaatct ggcccagtgg aataacgatt   2400

gacttcttaa ctgacaagtt gtactggtgc gatgccaagc agtctgtgat tgaaatggcc   2460

aatctggatg gttcaaaacg ccgaagactt acccagaatg atgtaggtca cccatttgct   2520

gtagcagtgt ttgaggatta tgtgtggttc tcagattggg ctatgccatc agtaatgaga   2580

gtaaacaaga ggactggcaa agatagagta cgtctccaag gcagcatgct gaagccctca   2640

tcactggttg tggttcatcc attggcaaaa ccaggagcag atccctgctt atatcaaaac   2700

ggaggctgtg aacatatttg caaaaagagg cttggaactg cttggtgttc gtgtcgtgaa   2760

ggttttatga aagcctcaga tgggaaaacg tgtctggctc tggatggtca tcagctgttg   2820

gcaggtggtg aagttgatct aaagaaccaa gtaacaccat tggacatctt gtccaagact   2880

agagtgtcag aagataacat tacagaatct caacacatgc tagtggctga aatcatggtg   2940

tcagatcaag atgactgtgc tcctgtggga tgcagcatgt atgctcggtg tatttcagag   3000

ggagaggatg ccacatgtca gtgtttgaaa ggatttgctg gggatggaaa actatgttct   3060

gatatagatg aatgtgagat gggtgtccca gtgtgccccc ctgcctcctc caagtgcatc   3120

aacaccgaag gtggttatgt ctgccggtgc tcagaaggct accaaggaga tgggattcac   3180

tgtcttgata ttgatgagtg ccaactgggg gagcacagct gtggagagaa tgccagctgc   3240

acaaatacag agggaggcta tacctgcatg tgtgctggac gcctgtctga accaggactg   3300

atttgccctg actctactcc accccctcac ctcagggaag atgaccacca ctattccgta   3360

agaaatagtg actctgaatg tcccctgtcc cacgatgggt actgcctcca tgatggtgtg   3420

tgcatgtata ttgaagcatt ggacaagtat gcatgcaact gtgttgttgg ctacatcggg   3480

gagcgatgtc agtaccgaga cctgaagtgg tgggaactgc gccacgctgg ccacgggcag   3540

cagcagaagg tcatcgtggt ggctgtctgc gtggtggtgc ttgtcatgct gctcctcctg   3600

agcctgtggg gggcccacta ctacaggact cagaagctgc tatcgaaaaa cccaaagaat   3660

ccttatgagg agtcgagcag agatgtgagg agtcgcaggc ctgctgacac tgaggatggg   3720

atgtcctctt gccctcaacc ttggtttgtg gttataaaag aacaccaaga cctcaagaat   3780

gggggtcaac cagtggctgg tgaggatggc caggcagcag atgggtcaat gcaaccaact   3840

tcatggaggc aggagcccca gttatgtgga atgggcacag agcaaggctg ctggattcca   3900

gtatccagtg ataagggctc ctgtccccag gtaatggagc gaagctttca tatgccctcc   3960

tatgggacac agacccttga agggggtgtc gagaagcccc attctctcct atcagctaac   4020

ccattatggc aacaaagggc cctggaccca ccacaccaaa tggagctgac tcagtgaaaa   4080

ctggaattaa aaggaaagtc aagaagaatg aactatgtcg atgcacagta tcttttcttt   4140

caaaagtaga gcaaaactat aggttttggt tccacaatct ctacgactaa tcacctactc   4200

aatgcctgga gacagatacg tagttgtgct tttgtttgct cttttaagca gtctcactgc   4260

agtcttattt ccaagtaaga gtactgggag aatcactagg taacttatta gaaacccaaa   4320

ttgggacaac agtgctttgt aaattgtgtt gtcttcagca gtcaatacaa atagattttt   4380

gtttttgttg ttcctgcagc cccagaagaa attaggggtt aaagcagaca gtcacactgg   4440

tttggtcagt tacaaagtaa tttctttgat ctggacagaa catttatatc agtttcatga   4500

aatgattgga atattacaat accgttaaga tacagtgtag gcatttaact cctcattggc   4560

gtggtccatg ctgatgattt tgcaaaatga gttgtgatga atcaatgaaa aatgtaattt   4620

agaaactgat ttcttcagaa ttagatggct tattttttaa aatatttgaa tgaaaacatt   4680

ttatttttaa aatattacac aggaggcttc ggagtttctt agtcattact gtccttttcc   4740

cctacagaat tttccctctt ggtgtgattg cacagaattt gtatgtattt tcagttacaa   4800

gattgtaagt aaattgcctg atttgttttc attatagaca acgatgaatt tcttctaatt   4860

atttaaataa aatcaccaaa aacataaaca tttt                               4894


<210>  2001
<211>  1207
<212>  PRT
<213>  Homo sapiens

<400>  2001


Met Leu Leu Thr Leu Ile Ile Leu Leu Pro Val Val Ser Lys Phe Ser 
1               5                   10                  15      


Phe Val Ser Leu Ser Ala Pro Gln His Trp Ser Cys Pro Glu Gly Thr 
            20                  25                  30          


Leu Ala Gly Asn Gly Asn Ser Thr Cys Val Gly Pro Ala Pro Phe Leu 
        35                  40                  45              


Ile Phe Ser His Gly Asn Ser Ile Phe Arg Ile Asp Thr Glu Gly Thr 
    50                  55                  60                  


Asn Tyr Glu Gln Leu Val Val Asp Ala Gly Val Ser Val Ile Met Asp 
65                  70                  75                  80  


Phe His Tyr Asn Glu Lys Arg Ile Tyr Trp Val Asp Leu Glu Arg Gln 
                85                  90                  95      


Leu Leu Gln Arg Val Phe Leu Asn Gly Ser Arg Gln Glu Arg Val Cys 
            100                 105                 110         


Asn Ile Glu Lys Asn Val Ser Gly Met Ala Ile Asn Trp Ile Asn Glu 
        115                 120                 125             


Glu Val Ile Trp Ser Asn Gln Gln Glu Gly Ile Ile Thr Val Thr Asp 
    130                 135                 140                 


Met Lys Gly Asn Asn Ser His Ile Leu Leu Ser Ala Leu Lys Tyr Pro 
145                 150                 155                 160 


Ala Asn Val Ala Val Asp Pro Val Glu Arg Phe Ile Phe Trp Ser Ser 
                165                 170                 175     


Glu Val Ala Gly Ser Leu Tyr Arg Ala Asp Leu Asp Gly Val Gly Val 
            180                 185                 190         


Lys Ala Leu Leu Glu Thr Ser Glu Lys Ile Thr Ala Val Ser Leu Asp 
        195                 200                 205             


Val Leu Asp Lys Arg Leu Phe Trp Ile Gln Tyr Asn Arg Glu Gly Ser 
    210                 215                 220                 


Asn Ser Leu Ile Cys Ser Cys Asp Tyr Asp Gly Gly Ser Val His Ile 
225                 230                 235                 240 


Ser Lys His Pro Thr Gln His Asn Leu Phe Ala Met Ser Leu Phe Gly 
                245                 250                 255     


Asp Arg Ile Phe Tyr Ser Thr Trp Lys Met Lys Thr Ile Trp Ile Ala 
            260                 265                 270         


Asn Lys His Thr Gly Lys Asp Met Val Arg Ile Asn Leu His Ser Ser 
        275                 280                 285             


Phe Val Pro Leu Gly Glu Leu Lys Val Val His Pro Leu Ala Gln Pro 
    290                 295                 300                 


Lys Ala Glu Asp Asp Thr Trp Glu Pro Glu Gln Lys Leu Cys Lys Leu 
305                 310                 315                 320 


Arg Lys Gly Asn Cys Ser Ser Thr Val Cys Gly Gln Asp Leu Gln Ser 
                325                 330                 335     


His Leu Cys Met Cys Ala Glu Gly Tyr Ala Leu Ser Arg Asp Arg Lys 
            340                 345                 350         


Tyr Cys Glu Asp Val Asn Glu Cys Ala Phe Trp Asn His Gly Cys Thr 
        355                 360                 365             


Leu Gly Cys Lys Asn Thr Pro Gly Ser Tyr Tyr Cys Thr Cys Pro Val 
    370                 375                 380                 


Gly Phe Val Leu Leu Pro Asp Gly Lys Arg Cys His Gln Leu Val Ser 
385                 390                 395                 400 


Cys Pro Arg Asn Val Ser Glu Cys Ser His Asp Cys Val Leu Thr Ser 
                405                 410                 415     


Glu Gly Pro Leu Cys Phe Cys Pro Glu Gly Ser Val Leu Glu Arg Asp 
            420                 425                 430         


Gly Lys Thr Cys Ser Gly Cys Ser Ser Pro Asp Asn Gly Gly Cys Ser 
        435                 440                 445             


Gln Leu Cys Val Pro Leu Ser Pro Val Ser Trp Glu Cys Asp Cys Phe 
    450                 455                 460                 


Pro Gly Tyr Asp Leu Gln Leu Asp Glu Lys Ser Cys Ala Ala Ser Gly 
465                 470                 475                 480 


Pro Gln Pro Phe Leu Leu Phe Ala Asn Ser Gln Asp Ile Arg His Met 
                485                 490                 495     


His Phe Asp Gly Thr Asp Tyr Gly Thr Leu Leu Ser Gln Gln Met Gly 
            500                 505                 510         


Met Val Tyr Ala Leu Asp His Asp Pro Val Glu Asn Lys Ile Tyr Phe 
        515                 520                 525             


Ala His Thr Ala Leu Lys Trp Ile Glu Arg Ala Asn Met Asp Gly Ser 
    530                 535                 540                 


Gln Arg Glu Arg Leu Ile Glu Glu Gly Val Asp Val Pro Glu Gly Leu 
545                 550                 555                 560 


Ala Val Asp Trp Ile Gly Arg Arg Phe Tyr Trp Thr Asp Arg Gly Lys 
                565                 570                 575     


Ser Leu Ile Gly Arg Ser Asp Leu Asn Gly Lys Arg Ser Lys Ile Ile 
            580                 585                 590         


Thr Lys Glu Asn Ile Ser Gln Pro Arg Gly Ile Ala Val His Pro Met 
        595                 600                 605             


Ala Lys Arg Leu Phe Trp Thr Asp Thr Gly Ile Asn Pro Arg Ile Glu 
    610                 615                 620                 


Ser Ser Ser Leu Gln Gly Leu Gly Arg Leu Val Ile Ala Ser Ser Asp 
625                 630                 635                 640 


Leu Ile Trp Pro Ser Gly Ile Thr Ile Asp Phe Leu Thr Asp Lys Leu 
                645                 650                 655     


Tyr Trp Cys Asp Ala Lys Gln Ser Val Ile Glu Met Ala Asn Leu Asp 
            660                 665                 670         


Gly Ser Lys Arg Arg Arg Leu Thr Gln Asn Asp Val Gly His Pro Phe 
        675                 680                 685             


Ala Val Ala Val Phe Glu Asp Tyr Val Trp Phe Ser Asp Trp Ala Met 
    690                 695                 700                 


Pro Ser Val Met Arg Val Asn Lys Arg Thr Gly Lys Asp Arg Val Arg 
705                 710                 715                 720 


Leu Gln Gly Ser Met Leu Lys Pro Ser Ser Leu Val Val Val His Pro 
                725                 730                 735     


Leu Ala Lys Pro Gly Ala Asp Pro Cys Leu Tyr Gln Asn Gly Gly Cys 
            740                 745                 750         


Glu His Ile Cys Lys Lys Arg Leu Gly Thr Ala Trp Cys Ser Cys Arg 
        755                 760                 765             


Glu Gly Phe Met Lys Ala Ser Asp Gly Lys Thr Cys Leu Ala Leu Asp 
    770                 775                 780                 


Gly His Gln Leu Leu Ala Gly Gly Glu Val Asp Leu Lys Asn Gln Val 
785                 790                 795                 800 


Thr Pro Leu Asp Ile Leu Ser Lys Thr Arg Val Ser Glu Asp Asn Ile 
                805                 810                 815     


Thr Glu Ser Gln His Met Leu Val Ala Glu Ile Met Val Ser Asp Gln 
            820                 825                 830         


Asp Asp Cys Ala Pro Val Gly Cys Ser Met Tyr Ala Arg Cys Ile Ser 
        835                 840                 845             


Glu Gly Glu Asp Ala Thr Cys Gln Cys Leu Lys Gly Phe Ala Gly Asp 
    850                 855                 860                 


Gly Lys Leu Cys Ser Asp Ile Asp Glu Cys Glu Met Gly Val Pro Val 
865                 870                 875                 880 


Cys Pro Pro Ala Ser Ser Lys Cys Ile Asn Thr Glu Gly Gly Tyr Val 
                885                 890                 895     


Cys Arg Cys Ser Glu Gly Tyr Gln Gly Asp Gly Ile His Cys Leu Asp 
            900                 905                 910         


Ile Asp Glu Cys Gln Leu Gly Glu His Ser Cys Gly Glu Asn Ala Ser 
        915                 920                 925             


Cys Thr Asn Thr Glu Gly Gly Tyr Thr Cys Met Cys Ala Gly Arg Leu 
    930                 935                 940                 


Ser Glu Pro Gly Leu Ile Cys Pro Asp Ser Thr Pro Pro Pro His Leu 
945                 950                 955                 960 


Arg Glu Asp Asp His His Tyr Ser Val Arg Asn Ser Asp Ser Glu Cys 
                965                 970                 975     


Pro Leu Ser His Asp Gly Tyr Cys Leu His Asp Gly Val Cys Met Tyr 
            980                 985                 990         


Ile Glu Ala Leu Asp Lys Tyr Ala  Cys Asn Cys Val Val  Gly Tyr Ile 
        995                 1000                 1005             


Gly Glu  Arg Cys Gln Tyr Arg  Asp Leu Lys Trp Trp  Glu Leu Arg 
    1010                 1015                 1020             


His Ala  Gly His Gly Gln Gln  Gln Lys Val Ile Val  Val Ala Val 
    1025                 1030                 1035             


Cys Val  Val Val Leu Val Met  Leu Leu Leu Leu Ser  Leu Trp Gly 
    1040                 1045                 1050             


Ala His  Tyr Tyr Arg Thr Gln  Lys Leu Leu Ser Lys  Asn Pro Lys 
    1055                 1060                 1065             


Asn Pro  Tyr Glu Glu Ser Ser  Arg Asp Val Arg Ser  Arg Arg Pro 
    1070                 1075                 1080             


Ala Asp  Thr Glu Asp Gly Met  Ser Ser Cys Pro Gln  Pro Trp Phe 
    1085                 1090                 1095             


Val Val  Ile Lys Glu His Gln  Asp Leu Lys Asn Gly  Gly Gln Pro 
    1100                 1105                 1110             


Val Ala  Gly Glu Asp Gly Gln  Ala Ala Asp Gly Ser  Met Gln Pro 
    1115                 1120                 1125             


Thr Ser  Trp Arg Gln Glu Pro  Gln Leu Cys Gly Met  Gly Thr Glu 
    1130                 1135                 1140             


Gln Gly  Cys Trp Ile Pro Val  Ser Ser Asp Lys Gly  Ser Cys Pro 
    1145                 1150                 1155             


Gln Val  Met Glu Arg Ser Phe  His Met Pro Ser Tyr  Gly Thr Gln 
    1160                 1165                 1170             


Thr Leu  Glu Gly Gly Val Glu  Lys Pro His Ser Leu  Leu Ser Ala 
    1175                 1180                 1185             


Asn Pro  Leu Trp Gln Gln Arg  Ala Leu Asp Pro Pro  His Gln Met 
    1190                 1195                 1200             


Glu Leu  Thr Gln 
    1205         

<210>  2002
<211>  783
<212>  DNA
<213>  Homo sapiens

<400>  2002
aaaagtattc ttaggtttga atctgttttc atttcctaag cagattattt catttgcaga     60

atgtgtgctt ttttgtgata aaagtacatt agaatgaaaa agctaataag tagtgtttag    120

tattcgcaac ctaagaaatg acatctccag ctaatcagga tgcccaatcc tgagaggttt    180

tggagaagta atacaattgg agaaaaaagt gggcttcggg atgctgggga atctgggctc    240

tggctaagtt tgcctccgtg agagatgcag ctgtagacgt tgtagggagg taagacctct    300

taagaatcag gaaaagattt agcagtgtcc tctgtcaaaa cacggcccca ctccaaataa    360

agcatcttct cttttagagc agaaactttg caaattgagg aaaggaaact gcagcagcac    420

tgtgtgtggg caagacctcc agtcacactt gtgcatgtgt gcagagggat acgccctaag    480

tcgagaccgg aagtactgtg aagatgttaa tgaatgtgct ttttggaatc atggctgtac    540

tcttgggtgt aaaaacaccc ctggatccta ttactgcacg tgccctgtag gatttgttct    600

gcttcctgat gggaaacgat gtcatcaact tgtttcctgt ccacgcaatg tgtctgaatg    660

cagccatgac tgtgttctga catcagaagg tcccttatgt ttctgtcctg aaggctcagt    720

gcttgagaga gatgggaaaa catgtagcgg ttgttcctca cccgataatg gtggatgtag    780

cca                                                                  783


<210>  2003
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  2003


Met Cys Ala Glu Gly Tyr Ala Leu Ser Arg Asp Arg Lys Tyr Cys Glu 
1               5                   10                  15      


Asp Val Asn Glu Cys Ala Phe Trp Asn His Gly Cys Thr Leu Gly Cys 
            20                  25                  30          


Lys Asn Thr Pro Gly Ser Tyr Tyr Cys Thr Cys Pro Val Gly Phe Val 
        35                  40                  45              


Leu Leu Pro Asp Gly Lys Arg Cys His Gln Leu Val Ser Cys Pro Arg 
    50                  55                  60                  


Asn Val Ser Glu Cys Ser His Asp Cys Val Leu Thr Ser Glu Gly Pro 
65                  70                  75                  80  


Leu Cys Phe Cys Pro Glu Gly Ser Val Leu Glu Arg Asp Gly Lys Thr 
                85                  90                  95      


Cys Ser Gly Cys Ser Ser Pro Asp Asn Gly Gly Cys 
            100                 105             

<210>  2004
<211>  427
<212>  DNA
<213>  Homo sapiens

<400>  2004
gaattgctgt tcatccaatg gccaagagat tattctggac tgatacaggg attaatccac     60

gaattgaaag ttcttccctc caaggccttg gccgtctggt tatagccagc tctgatctaa    120

tctggcccag tggaataacg attgacttct taactgacaa gttgtactgg tgcgatgcca    180

agcagtctgt gattgaaatg gccaatctgg atggttcaaa acgccgaaga cttacccaga    240

atgatgtagg tgacccaaag aatccttatg aggagtcgag cagagatgtg aggagtcgca    300

ggcctgctga cactgaggat gggatgtcct cttgccctca accttggttt gtggttataa    360

aagaacacca agacctcaag aatgggggtc aaccagtggc tggtgaggat ggccaggcag    420

cagatgg                                                              427


<210>  2005
<211>  135
<212>  PRT
<213>  Homo sapiens

<400>  2005


Met Ala Lys Arg Leu Phe Trp Thr Asp Thr Gly Ile Asn Pro Arg Ile 
1               5                   10                  15      


Glu Ser Ser Ser Leu Gln Gly Leu Gly Arg Leu Val Ile Ala Ser Ser 
            20                  25                  30          


Asp Leu Ile Trp Pro Ser Gly Ile Thr Ile Asp Phe Leu Thr Asp Lys 
        35                  40                  45              


Leu Tyr Trp Cys Asp Ala Lys Gln Ser Val Ile Glu Met Ala Asn Leu 
    50                  55                  60                  


Asp Gly Ser Lys Arg Arg Arg Leu Thr Gln Asn Asp Val Gly Asp Pro 
65                  70                  75                  80  


Lys Asn Pro Tyr Glu Glu Ser Ser Arg Asp Val Arg Ser Arg Arg Pro 
                85                  90                  95      


Ala Asp Thr Glu Asp Gly Met Ser Ser Cys Pro Gln Pro Trp Phe Val 
            100                 105                 110         


Val Ile Lys Glu His Gln Asp Leu Lys Asn Gly Gly Gln Pro Val Ala 
        115                 120                 125             


Gly Glu Asp Gly Gln Ala Ala 
    130                 135 

<210>  2006
<211>  567
<212>  DNA
<213>  Homo sapiens

<400>  2006
atcttagaat cagtggctcc ttgggggaac tcttctgaaa tagctattga tataccctct     60

atttagatac actgcatttc tctccctaaa agctatagct ccctaaaagc aagctgtaga    120

cttgcattaa tggcatcctt ttcatcttca aacccacttg tgaatttgtt tcttttctct    180

actaggagca gatccctgct tatatcaaaa cggaggctgt gaacatattt gcaaaaagag    240

gcttggaact gcttggtgtt cgtgtcgtga aggttttatg aaagcctcag atgggaaaac    300

gtgtctggct ctggatggtc atcagctgtt ggcaggtggt gaagttgatc taaagaacca    360

agtaacacca ttggacatct tgtccaagac tagagtgtca gaagataaca ttacagaatc    420

tcaacacatg ctagtggctg aaatcatggt gtcagatcaa gatgactgtg ctcctgtggg    480

atgcagcatg tatgctcggt gtatttcaga gggagaggat gccacatgtc agtgtttgaa    540

aggatttgct ggggatggaa aactatg                                        567


<210>  2007
<211>  95
<212>  PRT
<213>  Homo sapiens

<400>  2007


Met Lys Ala Ser Asp Gly Lys Thr Cys Leu Ala Leu Asp Gly His Gln 
1               5                   10                  15      


Leu Leu Ala Gly Gly Glu Val Asp Leu Lys Asn Gln Val Thr Pro Leu 
            20                  25                  30          


Asp Ile Leu Ser Lys Thr Arg Val Ser Glu Asp Asn Ile Thr Glu Ser 
        35                  40                  45              


Gln His Met Leu Val Ala Glu Ile Met Val Ser Asp Gln Asp Asp Cys 
    50                  55                  60                  


Ala Pro Val Gly Cys Ser Met Tyr Ala Arg Cys Ile Ser Glu Gly Glu 
65                  70                  75                  80  


Asp Ala Thr Cys Gln Cys Leu Lys Gly Phe Ala Gly Asp Gly Lys 
                85                  90                  95  

<210>  2008
<211>  1447
<212>  DNA
<213>  Homo sapiens

<400>  2008
cacacaaaca cacacacacc ctctacctca cagaaccttg gaaagagtga aacactgtct     60

ggaaagcatt ttgagttctg cagaaaagac tgccttaaac atctaaagtt atgttcctag    120

ttatcttcat atttcttctc tcccacacaa gtacttaaat tttagtagca aaagcagtta    180

gttgtccctg atcatcactg agtgggctga gtattttgtt ttgttgtgag attgtctcaa    240

attttggctt tatcacagga ctcagaagct gctatcgaaa aacccaaaga atccttatga    300

ggagtcgagc agagatgtga ggagtcgcag gcctgctgac actgaggatg ggatgtcctc    360

ttgccctcaa ccttggggtc aatgcaacca acttcatgga ggcaggagcc ccagttatgt    420

ggaatgggca cagagcaagg ctgctggatt ccagtatcca gtgataaggg ctcctgtccc    480

caggtaatgg agcgaagctt tcatatgccc tcctatggga cacagaccct tgaagggggt    540

gtcgagaagc cccattctct cctatcagct aacccattat ggcaacaaag ggccctggac    600

ccaccacacc aaatggagct gactcagtga aaactggaat taaaaggaaa gtcaagaaga    660

atgaactatg tcgatgcaca gtatcttttc tttcaaaagt agagcaaaac tataggtttt    720

ggttccacaa tctctacgac taatcaccta ctcaatgcct ggagacagat acgtagttgt    780

gcttttgttt gctcttttaa gcagtctcac tgcagtctta tttccaagta agagtactgg    840

gagaatcact aggtaactta ttagaaaccc aaattgggac aacagtgctt tgtaaattgt    900

gttgtcttca gcagtcaata caaatagatt tttgtttttg ttgttcctgc agccccagaa    960

gaaattaggg gttaaagcag acagtcacac tggtttggtc agttacaaag taatttcttt   1020

gatctggaca gaacatttat atcagtttca tgaaatgatt ggaatattac aataccgtta   1080

agatacagtg taggcattta actcctcatt ggcgtggtcc atgctgatga ttttgcaaaa   1140

tgagttgtga tgaatcaatg aaaaatgtaa tttagaaact gatttcttca gaattagatg   1200

gcttattttt taaaatattt gaatgaaaac attttatttt taaaatatta cacaggaggc   1260

ttcggagttt cttagtcatt actgtccttt tcccctacag aattttccct cttggtgtga   1320

ttgcacagaa tttgtatgta ttttcagtta caagattgta agtaaattgc ctgatttgtt   1380

ttcattatag acaacgatga atttcttcta attatttaaa taaaatcacc aaaaacataa   1440

acatttt                                                             1447


<210>  2009
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  2009


Met Ser Ser Cys Pro Gln Pro Trp Gly Gln Cys Asn Gln Leu His Gly 
1               5                   10                  15      


Gly Arg Ser Pro Ser Tyr Val Glu Trp Ala Gln Ser Lys Ala Ala Gly 
            20                  25                  30          


Phe Gln Tyr Pro Val Ile Arg Ala Pro Val Pro Arg 
        35                  40                  

<210>  2010
<211>  324
<212>  DNA
<213>  Homo sapiens

<400>  2010
acaggactca gaagctgcta tcgaaaaacc caaagaatcc ttatgaggag tcgagcagag     60

atgtgaggag tcgcaggcct gctgacactg aggatgggat gtcctcttgc cctcaacctt    120

ggggtcaatg caaccaactt catggaggca ggagccccag ttatgtggaa tgggcacaga    180

gcaaggctgc tggattccag tatccagtga taagggctcc tgtccccaga attttccctc    240

ttggtgtgat tgcacagaat ttgtatgtat tttcagttac aagattgtaa gtaaattgcc    300

tgatttgttt tcattataga caac                                           324


<210>  2011
<211>  63
<212>  PRT
<213>  Homo sapiens

<400>  2011


Met Gln Pro Thr Ser Trp Arg Gln Glu Pro Gln Leu Cys Gly Met Gly 
1               5                   10                  15      


Thr Glu Gln Gly Cys Trp Ile Pro Val Ser Ser Asp Lys Gly Ser Cys 
            20                  25                  30          


Pro Gln Asn Phe Pro Ser Trp Cys Asp Cys Thr Glu Phe Val Cys Ile 
        35                  40                  45              


Phe Ser Tyr Lys Ile Val Ser Lys Leu Pro Asp Leu Phe Ser Leu 
    50                  55                  60              

<210>  2012
<211>  3876
<212>  DNA
<213>  Homo sapiens

<400>  2012
attcttcatg agatcctgct ctgaatctgt tacccttttt catgacctct ttttggaaca     60

gtgatgaaga ggaagtggta tcatatatgg tttcagaata aagcccttga gtcattgtat    120

tagctcttgt ttacagaaca ttttaagatg ctttcaagga aatacaaata atatgattct    180

tatgcctatt tcctgccagt ggccaaccag tcttctaagt atggttgatg tgagaagtga    240

aactattttc ctaaatgctg tttcttttct cttttcatta tgaagtatat tcggtgctct    300

tcgaactggt gcttatatgg tgtacatttt gatgaccaaa ggcctgaagc agtcagtttg    360

tgaccagggt ttttacaatg gacctgtcag caaattctgg gcttatgcat ttgtgctaag    420

caaagcaccc gaactaggag atacaatatt cattattctg aggaagcaga agctgatctt    480

cctgcactgg tatcaccaca tcactgtgct cctgtactct tggtactcct acaaagacat    540

ggttgccggg ggaggttggt tcatgactat gaactatggc gtgcacgccg tgatgtactc    600

ttactatgcc ttgcgggcgg caggtttccg agtctcccgg aagtttgcca tgttcatcac    660

cttgtcccag atcactcaga tgctgatggg ctgtgtggtt aactacctgg tcttctgctg    720

gatgcagcat gaccagtgtc actctcactt tcagaacatc ttctggtcct cactcatgta    780

cctcagctac cttgtgctct tctgccattt cttctttgag gcctacatcg gcaaaatgag    840

gaaaacaacg aaagctgaat agtgttggaa ctgaggagga agccatagct cagggtcatc    900

aagaaaaata atagacaaaa gaaaatggca caaggaatca cacgtggtgc agctaaaaca    960

aaacaaaaca tgagcaaaca caaaacccaa ggcagcttag ggataattag gttgatttaa   1020

cccagtaagt ttatgatcct tttagggtga ggactcactg agtgcacctc catctccaag   1080

cactgctgct ggaagacccc attccctctt tatctatcaa ctctaggaca agggagaaca   1140

aaagcaagcc agaagcagag gagactaatc aaaggcaaac aaaggctatt aacacatagg   1200

aaaaaatgta tttactaagt gtcacatttc tctaagatga aagattttta ctctagaaac   1260

tgtgcgagca caacacacac aatcctttct aactttatgg acactaaact ggagccaata   1320

gaaaagacaa aaatgaaaga gacacagggt gtatatctag aacgataatg cttttgcaga   1380

aactaaagcc tttttaagaa atgccagctg ctgtagaccc catgagaaaa gatgtcttaa   1440

tcatccttat gaaaacagat gtaaacaact atatttcaac taacttcatc ttcactgcat   1500

agcctcaggc tagtgagttt gccaaaacca aagggggtga atacttcccc aagattcttc   1560

ctgggaggat ggaaacagtg cagcccaggt cccatggggg cagctccatc ccagagcatt   1620

tctgatagtt gaactgtaat ttctactctt aagtgagata tgaagcatta tccttttgtt   1680

cagttgcccc gggcttttga acagaagagt aaatacagaa ttgaaaaaga taaacactca   1740

accaaacaat gtgaaaacgg gttctgtagt atttgtaaaa aggcccggcc caggaccact   1800

gtgagctgga aaagggagaa aggcagtggg aaaagaggtg agccgaagat caattcgaca   1860

gacagatggt gtgtatgccc ctccctgttt gacttcacac acactcataa ctttccaaat   1920

gaaaccccac agtatagcgc atattttcga tatttttgtg aattccaaaa ggaaatcaca   1980

gggctgttcg aaatattggg ggaacactgt gtttctgcat catctgcatt tgctccccaa   2040

gcaatgtaga ggtgtttaaa gggccctctg ctggctgagt ggcaatacta caacaaactt   2100

caaggcaagt ttggctgaaa acagttgaca acaaagggcc cccatacact tatccctcaa   2160

attttaagtg atatgaaata cttgtcatgt ctttggccaa atcagaagat attcatcctg   2220

cttcaagtca gcttcagaaa tgttttaaaa gggactttag ctctggaact caaaatcaat   2280

ttattaagag ccatattctt taaaaaaaaa aagctggata atattctctg taatatttca   2340

gtcctttaca agccaaatac atgtgtcaat gtttctagta tttcaaagaa gcaattatgt   2400

aaagttgttc aatgtgacat aatagtatta taattggtta agtagcttaa tgattaggca   2460

aactagatga aaagattagg ggcttccaca ctgcatagat tacacgcaca tagccacgca   2520

tacacacaca gacacacaga tgtggggtac actgaacttc aaagcccaaa tgaatagaaa   2580

cacattttct ggctagcaga aaaaaacaaa acaaaactgt tgtttctctt tcttgctttg   2640

agagtgtaca gtaaaaggga ttttttcgaa ttatttttat attattttag ctttaattgt   2700

gctgtcgttc atgaaacaga gctgctctgc ttttctgtca gagatggcaa gggctttttc   2760

agcatctcgt ttatgtgtgg aatttaaaaa gaataaagtt ttattccatt ctgtgtgaat   2820

ggtttgagca gtgaacaaag aatccatgca aaccaagtca tgactggaag aaatggggag   2880

tgggggacag tgcaggggag gaaagctgtt acatctatgt taaatgattg tgagcagtct   2940

ataatgtctt gatgttggtt cataggtgag acacaactga tggaggaatg tattataaat   3000

tatgcaaaat ctgacatgag ctgaaaagac aggtcctttt ataagagcta atagatgctt   3060

aggatgcaaa tgttattttg agcttcgcaa atacatgata ccgtgcaata agcctttttt   3120

ccttataaca gaaaatgaga ataattaaaa tgaggagaag gccacataac agttgacttg   3180

aatttaattg aaggacccat tggaggctca tctggttgat ttaattattt aattgagtga   3240

tttattgcag atctcttaat gcaggttaga aacggaagtg agcataaacc ttaaaaagac   3300

tctaaatgat gcttccaaag cactttcatt ttggtattag gttcatgttt gtttgtcttt   3360

acttgtaaaa taatttggaa tttttgttta cagggtgaat gtcttaatag ttttaaaatt   3420

agctaaatat atctaaaggc atttccaatg tttatcatgg gaggaaaaaa gccacatttt   3480

ttttaaaaca aaacaaaaca aaacaaaatt ttggtaatat aggttcaata cactgttttt   3540

aacatctcag cttagccgct ttaatcatat caagatatga ggctggatca ctggcccatg   3600

acaaatctga aacctaccag agaattgact gctgcataga taatcctgct gccagttaac   3660

attccagaaa aacttgggca ggcaagtttt tatagctgcc ccactatgct gcaatagagt   3720

atctttctat tgaagatttt ccactgcatc ccgatcctac tatggtgaaa gcattgttct   3780

tgggctaaaa aaaaatcctt tatttcatac acacatgatt tcatacacta ggtctgagca   3840

tcaagccaag tccatgagtt tgcaatgaag ttctag                             3876


<210>  2013
<211>  181
<212>  PRT
<213>  Homo sapiens

<400>  2013


Met Val Tyr Ile Leu Met Thr Lys Gly Leu Lys Gln Ser Val Cys Asp 
1               5                   10                  15      


Gln Gly Phe Tyr Asn Gly Pro Val Ser Lys Phe Trp Ala Tyr Ala Phe 
            20                  25                  30          


Val Leu Ser Lys Ala Pro Glu Leu Gly Asp Thr Ile Phe Ile Ile Leu 
        35                  40                  45              


Arg Lys Gln Lys Leu Ile Phe Leu His Trp Tyr His His Ile Thr Val 
    50                  55                  60                  


Leu Leu Tyr Ser Trp Tyr Ser Tyr Lys Asp Met Val Ala Gly Gly Gly 
65                  70                  75                  80  


Trp Phe Met Thr Met Asn Tyr Gly Val His Ala Val Met Tyr Ser Tyr 
                85                  90                  95      


Tyr Ala Leu Arg Ala Ala Gly Phe Arg Val Ser Arg Lys Phe Ala Met 
            100                 105                 110         


Phe Ile Thr Leu Ser Gln Ile Thr Gln Met Leu Met Gly Cys Val Val 
        115                 120                 125             


Asn Tyr Leu Val Phe Cys Trp Met Gln His Asp Gln Cys His Ser His 
    130                 135                 140                 


Phe Gln Asn Ile Phe Trp Ser Ser Leu Met Tyr Leu Ser Tyr Leu Val 
145                 150                 155                 160 


Leu Phe Cys His Phe Phe Phe Glu Ala Tyr Ile Gly Lys Met Arg Lys 
                165                 170                 175     


Thr Thr Lys Ala Glu 
            180     

<210>  2014
<211>  8003
<212>  DNA
<213>  Homo sapiens

<400>  2014
acagtctgag gctgtaatgg gaaagtcggt tcctgggctg ctgtctcata gacatcagct     60

tgcagggaag ctgggggctc tccgaattgc cctgctccgg ggcccctcct gctgcgtgac    120

tcacaggcac attgcagaga gaagctgccg ctcccagtaa gtagtctgac agcaatgcaa    180

gcttcctccg tgctgccaga gcaggcaacc tggacaaagt tgtggaatat ctgaaggggg    240

gcatagacat caatacctgc aatcagaatg gactcaacgc tctccatctg gctgccaagg    300

aaggccacgt ggggctggtg caggagctgc tgggaagagg gtcctctgtg gattctgcca    360

ctaagaaggg aaataccgct cttcacattg catctttggc tggacaagca gaagttgtca    420

aagttcttgt taaggaagga gccaatatta atgcacagtc tcagaatggc tttactcctt    480

tatacatggc tgcccaagag aatcacattg atgttgtaaa atatttgctg gaaaatggag    540

ctaatcagag cactgctaca gaggatggct ttactcctct agctgtggca ctccagcaag    600

gacacaacca ggcggtggcc atcctcttgg agaatgacac caaagggaaa gtgaggctgc    660

cagctctgca tattgccgct aggaaagacg acaccaaatc tgccgcactt ctgcttcaga    720

atgaccacaa tgctgacgta caatccaaga tgatggtgaa taggacaact gagagtggtt    780

ttaccccttt gcacatagct gcacattacg gaaatgtcaa cgtggcaact cttcttctaa    840

accggggagc tgctgtggac ttcacagcca ggaatggaat cactcctctg catgtggctt    900

ccaaaagagg aaatacaaac atggtgaagc tcttactgga tcgaggcggt cagatcgatg    960

ccaaaactag ggatgggttg acaccacttc actgtgctgc acgaagtggg catgaccaag   1020

tggtggaact tctgttggaa cggggtgccc ccttgctggc aaggactaag aatgggctgt   1080

ctccactaca catggctgcc cagggagacc acgtggaatg tgtgaagcac ctgttacagc   1140

acaaggcacc tgttgatgat gtcaccctag actacctgac agccctccac gttgctgcgc   1200

actgtggcca ctaccgtgta accaaactcc ttttagacaa gagagccaat ccgaacgcca   1260

gagccctgaa tggttttact ccactgcaca ttgcctgcaa gaaaaaccgc atcaaagtca   1320

tggaactgct ggtgaaatat ggggcttcaa tccaagctat aacagagtct ggcctcacac   1380

caatacatgt ggctgccttc atgggccact tgaacattgt cctccttctg ctgcagaacg   1440

gagcctctcc agatgtcact aacattcgtg gtgagacggc actacacatg gcagcccgag   1500

ccgggcaggt ggaagtggtc cgatgcctcc tgagaaatgg tgcccttgtt gatgccagag   1560

ccagggagga acagacacct ttacatattg cctcccgcct gggtaagaca gaaattgtcc   1620

agctgcttct acaacatatg gctcatccag atgcggccac tacaaatggg tacacaccac   1680

tgcacatctc tgcccgggag ggccaggtgg atgtggcatc agtcctattg gaagcaggag   1740

cagcccactc cttagctacc aagaagggtt ttactcccct gcatgtagca gccaagtatg   1800

gaagcctgga tgtggcaaaa cttctcttgc aacgccgtgc tgccgcagat tctgcaggga   1860

agaacggcct taccccgctc catgttgctg ctcattatga caaccagaag gtggcgctgc   1920

tgttactgga gaagggtgct tcccctcatg ccactgccaa gaatggctat actccgttac   1980

atattgctgc caagaagaat caaatgcaga tagcttccac actcctgaac tatggagcag   2040

agacaaacat tgtgacaaag caaggagtaa ctccactcca tctggcctcg caggaggggc   2100

acacagatat ggttaccttg cttctggata agggagccaa tatccacatg tcaactaaga   2160

gtggactcac atccttacac cttgcagccc aggaagataa agtgaatgtt gctgatattc   2220

tcaccaagca tggagctgat caggatgctc atacaaagct tggttacaca cctttaattg   2280

tggcctgtca ctatggaaat gtgaaaatgg tcaactttct tctgaagcag ggagcaaatg   2340

ttaacgcaaa aaccaagaac ggctacacgc ctttgcacca ggccgctcag cagggtcaca   2400

cgcacatcat caacgtcctg ctccagcatg gggccaagcc caacgccacc actgcgaatg   2460

gcaacactgc cttggcgatt gctaagcgtc tgggctacat ctccgtggtc gacaccctga   2520

aggttgtgac tgaggaggtc accaccacca ccacaactat tacagaaaaa cacaaactaa   2580

atgtacctga gacgatgact gaggttcttg atgtttctga tgaagagggt gatgacacaa   2640

tgactggtga tgggggagaa taccttaggc ctgaggacct aaaagaactg ggtgatgact   2700

cactacccag cagtcagttc ctggatggta tgaattacct gcgatacagc ttggagggag   2760

gacgatctga cagccttcga tccttcagtt ccgacaggtc tcacactctg agccatgcct   2820

cctacctgag ggacagtgcc gtgatggatg actcagttgt gattcccagt caccaggtgt   2880

caactctagc caaggaggca gaaaggaatt cttatcgcct aagctggggc actgagaact   2940

tagacaacgt ggctctttct tctagtccta ttcattcagg ccgcgcctct ccatgtcttg   3000

aacgtgacaa cagcagtttc ctggttagtt ttatggtgga tgcccgaggt ggtgctatgc   3060

gaggatgcag acacaatggg ctccgaatca ttattccacc tcggaaatgt actgctccaa   3120

cgcgagtcac ctgccgactg gtcaagcgcc acagactggc aacaatgcct ccaatggtgg   3180

aaggagaagg cctggccagt cgcctgatcg aagttggacc ttctggtgct cagttccttg   3240

gtaaacttca cctgccaacg gctcctcccc cacttaatga gggagaaagt ttggtcagcc   3300

gcattcttca gctggggcct cctggaacca aattccttgg gcctgtgatc gtggagatcc   3360

ctcactttgc ggcccttcga ggaaaggaaa gggaactggt ggtcctgcgc agtgagaatg   3420

gggacagctg gaaagagcat ttctgtgact acactgaaga tgaattgaat gaaattctta   3480

acggcatgga tgaagtactg gatagcccag aagacctaga aaagaaacga atctgccgca   3540

tcatcacccg agacttccca cagtactttg cagtggtgtc tcgtatcaaa caggacagca   3600

atctgattgg cccagaagga ggtgtactga gcagcacagt ggtgccccag gtgcaggccg   3660

tcttcccaga gggggcactc accaagcgga tccgcgtagg cctgcaggct caacctatgc   3720

acagtgagct ggttaagaag atcctaggca acaaagctac cttcagccct atagtcactt   3780

tggaacctag aagaagaaaa ttccacaaac caattaccat gaccattcct gtccccaaag   3840

cttcaagtga tgtcatgttg aatggttttg ggggagatgc accaacctta agattactat   3900

gcagcataac aggtggaacc acccctgccc agtgggaaga tattacagga actacgccat   3960

taacatttgt caatgaatgt gtttccttta caacaaacgt gtctgccagg ttctggctga   4020

tagattgtcg acagatccag gaatccgtta cttttgcatc acaagtatac agagaaatta   4080

tctgcgtacc ttatatggcc aaatttgtag tgtttgccaa atcacatgac cccattgaag   4140

ccaggttgag gtgtttctgc atgactgatg ataaagtgga taagaccctt gaacaacaag   4200

aaaattttgc tgaggtggcc agaagcaggg atgtggaggt gttagaagga aaacccatct   4260

acgttgattg tttcggcaac ttggtaccat taactaaaag tggccagcat catatattca   4320

gtttttttgc cttcaaagaa aatagacttc ctctatttgt caaggtacgc gatacgactc   4380

aggaaccttg cggacgacta tcatttatga aggagccaaa atccacgaga ggcctggtgc   4440

atcaagctat ttgcaactta aacatcactt tgccgattta tacaaaggaa tcagagtcag   4500

atcaagaaca ggaggaagag atcgatatga catcagaaaa aaatccacag gatgagcagg   4560

aacggatcga ggaaaggctg gcttatattg ctgatcacct tggcttcagc tggacagaat   4620

tagcaagaga actggatttc actgaggagc aaattcatca aattcgaatt gaaaatccca   4680

actctcttca agaccagagt catgcactgt tgaagtactg gctagagagg gatgggaaac   4740

atgctacaga taccaacctc gttgaatgtc tcaccaagat caaccgaatg gatattgttc   4800

atctcatgga gaccaacaca gaacctctcc aggagcgcat cagtcatagt tatgcagaaa   4860

ttgaacagac cattacactg gatcatagtg aagggttctc ggtacttcaa gaggagttat   4920

gcactgcaca gcacaagcag aaagaggagc aagctgtttc taaagaaagt gagacctgcg   4980

atcaccctcc tatcgtctca gaggaagaca tttctgttgg ttattccact tttcaggatg   5040

gcgtccccaa aactgagggg gacagctcag caacagcact ctttccccaa actcacaagg   5100

agcaagttca acaggatttc tcagggaaaa tgcaagacct gcctgaagag tcatctctgg   5160

aatatcagca ggaatatttt gtgacaactc caggaacaga aacatcagag actcagaagg   5220

ctatgatagt acccagctct cccagcaaga cacctgagga agttagcacc cctgcagagg   5280

aggagaagct gtacctccag accccaacat ccagcgagcg gggaggctct cccatcatac   5340

aagaacccga agagccctca gagcacagag aggagagctc tccgcggaaa accagcctcg   5400

taatagtgga gtctgccgat aaccagcctg agacctgtga aagactcgat gaagatgcag   5460

cttttgaaaa gggagacgat atgcctgaaa tacccccaga aacagtcaca gaagaagaat   5520

acattgatga gcatggacac accgtggtaa agaaggttac taggaaaatc attaggcggt   5580

atgtatcctc tgaaggcaca gagaaagaag agattatggt gcagggaatg ccacaggaac   5640

ctgtcaacat cgaggaaggg gatggctatt ccaaagttat aaagcgtgtt gtattgaaga   5700

gtgacaccga gcagtcagag gacaacaatg agtaaagcca tcacacagaa gagggctgtg   5760

gtgaaggacc agcatggaaa acgcattgac ttggagcacc tggaggatgt accagaagca   5820

ctagaccagg acgacctcca gcgcgatctc cagcagctcc ttcggcattt ctgcaaggag   5880

gacttgaagc aagaggccaa gtgaggggct gcccagttct cacaccagaa accacacatt   5940

cactcaatat gcagcttcct gtttcagtag gggagtgacc taactggcct aattaatggg   6000

ataccccgac atttccactg ttagcaaata tacggcattt tgctttagtt ttcccccatc   6060

ctctttaact ataaagctaa tttgtgacca aagatggcat ccttcatact ggatgctgta   6120

tccaatactt tgttgtgtct gtgctaacct gggaactggc cacctccatt gttctttgct   6180

tctgcacaag atccatgaaa atccattgat cagaagaact tcacctgcag acctcttcaa   6240

gtgacactat gtaggaatcc ttccaaggaa tatctatgta caatgtatat agctgaaatg   6300

ctcagatgaa caacatatta aaattaaaac cactgcctat tgtaactaca ctgggcatca   6360

gaataaaagg cctctagaaa ttgctgaaca atggttaatt aagatattgc taacacaatc   6420

gagtgataat acagttttac tgcaaaagaa gcacttcaaa cctattatgt ccttagaact   6480

tccagagtag ccactgctcc cagttaaagg tgggtcagta gccttgcaga actgtcctga   6540

gaagttattg ctggtgctgg ccagccatgg cttaggactc caacagccac tctgagggag   6600

gggagaaggg agcagaggcc acgcagaatg aaccgatggg gtattcagtt gctggcagct   6660

acattgtgtg gcattctagc atcttcaggt ctttagatct tggacaagtt ggcagggtat   6720

tttaaaagct ataactactg tagttttcca gttttcattg ctgctttagc aaaccacgct   6780

gtcttacagt ggtactttct tctggccact gcactgtaga taattcattg gaaacaagat   6840

ttacccacta cataaaaggt taaactcctt cagtatgttg gagtggtttc tttttttttt   6900

tctttctttc ttttttttct tcaggtttat atcttctcta atacctgcat gtggcgttta   6960

aaaatcaaga ccacggtcaa acccctcttc taatcacatt aattgtttcc attcttttta   7020

ccctgagtga gcacttttca ctttccagct aggtctgttt ttcagcttgc agacaagatt   7080

gagaaatcct tgaaaatttg gttttggtta aaatttttgg tttatttatt tgaaatccac   7140

actcccttgg aaactcttaa gtgcatttgt gcacttctgt ttgtttgtct caaagaaggg   7200

actgtaacaa tctgagtaat ttccatgtcc tcttccttat tcctctagtg gttgaagctg   7260

tgtagcattt taacatatat atattcacaa atatattcat ataaacagta tacattttga   7320

atcagtcatt tgttaaagaa aagtatattc aatgaagatg aaatttaaat aaaaaaggac   7380

agagtctatc ctccagggat tgaacatttt ccaattatct ggtcttttcc tgttgtgcaa   7440

aaatgactca ttgctccgaa tgtcaaaaac aaatgcgaca aacaatggca cttcatcatt   7500

taaagtaatg ttgccaagag aaaaaatttc ctgggaggga ggtttcccac aagccaaatc   7560

tcctaagcct caaatgctag cactttttgg cagttggata ggaaatgaga cattctttgg   7620

cagccaaaat aagagaggcc gatggtgaaa ctttttgaga caccctatgg ccttcttgtc   7680

aaaaccttca ctggagctca agaaaagcat ttctgttgtg ttatttgcag tgcagatgat   7740

gtctgtgtaa caacataatg gttattcacc tttttttgat tttgattttt gctgtgttat   7800

caaaaacttg aatactgtga gaagaagtga attttcagtt gacgaatcag catcttgttc   7860

ccatggtgat aacactaatt gaatatatct atgagggcat gtattagtta atggaaaaaa   7920

aaatacaaca ctaacaatac atagctgcaa tgtgtacaat ggctgattta attaaataaa   7980

atgtacaagt gttaaatgtg gca                                           8003


<210>  2015
<211>  1749
<212>  PRT
<213>  Homo sapiens

<400>  2015


Met Ala Ala Gln Glu Asn His Ile Asp Val Val Lys Tyr Leu Leu Glu 
1               5                   10                  15      


Asn Gly Ala Asn Gln Ser Thr Ala Thr Glu Asp Gly Phe Thr Pro Leu 
            20                  25                  30          


Ala Val Ala Leu Gln Gln Gly His Asn Gln Ala Val Ala Ile Leu Leu 
        35                  40                  45              


Glu Asn Asp Thr Lys Gly Lys Val Arg Leu Pro Ala Leu His Ile Ala 
    50                  55                  60                  


Ala Arg Lys Asp Asp Thr Lys Ser Ala Ala Leu Leu Leu Gln Asn Asp 
65                  70                  75                  80  


His Asn Ala Asp Val Gln Ser Lys Met Met Val Asn Arg Thr Thr Glu 
                85                  90                  95      


Ser Gly Phe Thr Pro Leu His Ile Ala Ala His Tyr Gly Asn Val Asn 
            100                 105                 110         


Val Ala Thr Leu Leu Leu Asn Arg Gly Ala Ala Val Asp Phe Thr Ala 
        115                 120                 125             


Arg Asn Gly Ile Thr Pro Leu His Val Ala Ser Lys Arg Gly Asn Thr 
    130                 135                 140                 


Asn Met Val Lys Leu Leu Leu Asp Arg Gly Gly Gln Ile Asp Ala Lys 
145                 150                 155                 160 


Thr Arg Asp Gly Leu Thr Pro Leu His Cys Ala Ala Arg Ser Gly His 
                165                 170                 175     


Asp Gln Val Val Glu Leu Leu Leu Glu Arg Gly Ala Pro Leu Leu Ala 
            180                 185                 190         


Arg Thr Lys Asn Gly Leu Ser Pro Leu His Met Ala Ala Gln Gly Asp 
        195                 200                 205             


His Val Glu Cys Val Lys His Leu Leu Gln His Lys Ala Pro Val Asp 
    210                 215                 220                 


Asp Val Thr Leu Asp Tyr Leu Thr Ala Leu His Val Ala Ala His Cys 
225                 230                 235                 240 


Gly His Tyr Arg Val Thr Lys Leu Leu Leu Asp Lys Arg Ala Asn Pro 
                245                 250                 255     


Asn Ala Arg Ala Leu Asn Gly Phe Thr Pro Leu His Ile Ala Cys Lys 
            260                 265                 270         


Lys Asn Arg Ile Lys Val Met Glu Leu Leu Val Lys Tyr Gly Ala Ser 
        275                 280                 285             


Ile Gln Ala Ile Thr Glu Ser Gly Leu Thr Pro Ile His Val Ala Ala 
    290                 295                 300                 


Phe Met Gly His Leu Asn Ile Val Leu Leu Leu Leu Gln Asn Gly Ala 
305                 310                 315                 320 


Ser Pro Asp Val Thr Asn Ile Arg Gly Glu Thr Ala Leu His Met Ala 
                325                 330                 335     


Ala Arg Ala Gly Gln Val Glu Val Val Arg Cys Leu Leu Arg Asn Gly 
            340                 345                 350         


Ala Leu Val Asp Ala Arg Ala Arg Glu Glu Gln Thr Pro Leu His Ile 
        355                 360                 365             


Ala Ser Arg Leu Gly Lys Thr Glu Ile Val Gln Leu Leu Leu Gln His 
    370                 375                 380                 


Met Ala His Pro Asp Ala Ala Thr Thr Asn Gly Tyr Thr Pro Leu His 
385                 390                 395                 400 


Ile Ser Ala Arg Glu Gly Gln Val Asp Val Ala Ser Val Leu Leu Glu 
                405                 410                 415     


Ala Gly Ala Ala His Ser Leu Ala Thr Lys Lys Gly Phe Thr Pro Leu 
            420                 425                 430         


His Val Ala Ala Lys Tyr Gly Ser Leu Asp Val Ala Lys Leu Leu Leu 
        435                 440                 445             


Gln Arg Arg Ala Ala Ala Asp Ser Ala Gly Lys Asn Gly Leu Thr Pro 
    450                 455                 460                 


Leu His Val Ala Ala His Tyr Asp Asn Gln Lys Val Ala Leu Leu Leu 
465                 470                 475                 480 


Leu Glu Lys Gly Ala Ser Pro His Ala Thr Ala Lys Asn Gly Tyr Thr 
                485                 490                 495     


Pro Leu His Ile Ala Ala Lys Lys Asn Gln Met Gln Ile Ala Ser Thr 
            500                 505                 510         


Leu Leu Asn Tyr Gly Ala Glu Thr Asn Ile Val Thr Lys Gln Gly Val 
        515                 520                 525             


Thr Pro Leu His Leu Ala Ser Gln Glu Gly His Thr Asp Met Val Thr 
    530                 535                 540                 


Leu Leu Leu Asp Lys Gly Ala Asn Ile His Met Ser Thr Lys Ser Gly 
545                 550                 555                 560 


Leu Thr Ser Leu His Leu Ala Ala Gln Glu Asp Lys Val Asn Val Ala 
                565                 570                 575     


Asp Ile Leu Thr Lys His Gly Ala Asp Gln Asp Ala His Thr Lys Leu 
            580                 585                 590         


Gly Tyr Thr Pro Leu Ile Val Ala Cys His Tyr Gly Asn Val Lys Met 
        595                 600                 605             


Val Asn Phe Leu Leu Lys Gln Gly Ala Asn Val Asn Ala Lys Thr Lys 
    610                 615                 620                 


Asn Gly Tyr Thr Pro Leu His Gln Ala Ala Gln Gln Gly His Thr His 
625                 630                 635                 640 


Ile Ile Asn Val Leu Leu Gln His Gly Ala Lys Pro Asn Ala Thr Thr 
                645                 650                 655     


Ala Asn Gly Asn Thr Ala Leu Ala Ile Ala Lys Arg Leu Gly Tyr Ile 
            660                 665                 670         


Ser Val Val Asp Thr Leu Lys Val Val Thr Glu Glu Val Thr Thr Thr 
        675                 680                 685             


Thr Thr Thr Ile Thr Glu Lys His Lys Leu Asn Val Pro Glu Thr Met 
    690                 695                 700                 


Thr Glu Val Leu Asp Val Ser Asp Glu Glu Gly Asp Asp Thr Met Thr 
705                 710                 715                 720 


Gly Asp Gly Gly Glu Tyr Leu Arg Pro Glu Asp Leu Lys Glu Leu Gly 
                725                 730                 735     


Asp Asp Ser Leu Pro Ser Ser Gln Phe Leu Asp Gly Met Asn Tyr Leu 
            740                 745                 750         


Arg Tyr Ser Leu Glu Gly Gly Arg Ser Asp Ser Leu Arg Ser Phe Ser 
        755                 760                 765             


Ser Asp Arg Ser His Thr Leu Ser His Ala Ser Tyr Leu Arg Asp Ser 
    770                 775                 780                 


Ala Val Met Asp Asp Ser Val Val Ile Pro Ser His Gln Val Ser Thr 
785                 790                 795                 800 


Leu Ala Lys Glu Ala Glu Arg Asn Ser Tyr Arg Leu Ser Trp Gly Thr 
                805                 810                 815     


Glu Asn Leu Asp Asn Val Ala Leu Ser Ser Ser Pro Ile His Ser Gly 
            820                 825                 830         


Arg Ala Ser Pro Cys Leu Glu Arg Asp Asn Ser Ser Phe Leu Val Ser 
        835                 840                 845             


Phe Met Val Asp Ala Arg Gly Gly Ala Met Arg Gly Cys Arg His Asn 
    850                 855                 860                 


Gly Leu Arg Ile Ile Ile Pro Pro Arg Lys Cys Thr Ala Pro Thr Arg 
865                 870                 875                 880 


Val Thr Cys Arg Leu Val Lys Arg His Arg Leu Ala Thr Met Pro Pro 
                885                 890                 895     


Met Val Glu Gly Glu Gly Leu Ala Ser Arg Leu Ile Glu Val Gly Pro 
            900                 905                 910         


Ser Gly Ala Gln Phe Leu Gly Lys Leu His Leu Pro Thr Ala Pro Pro 
        915                 920                 925             


Pro Leu Asn Glu Gly Glu Ser Leu Val Ser Arg Ile Leu Gln Leu Gly 
    930                 935                 940                 


Pro Pro Gly Thr Lys Phe Leu Gly Pro Val Ile Val Glu Ile Pro His 
945                 950                 955                 960 


Phe Ala Ala Leu Arg Gly Lys Glu Arg Glu Leu Val Val Leu Arg Ser 
                965                 970                 975     


Glu Asn Gly Asp Ser Trp Lys Glu His Phe Cys Asp Tyr Thr Glu Asp 
            980                 985                 990         


Glu Leu Asn Glu Ile Leu Asn Gly  Met Asp Glu Val Leu  Asp Ser Pro 
        995                 1000                 1005             


Glu Asp  Leu Glu Lys Lys Arg  Ile Cys Arg Ile Ile  Thr Arg Asp 
    1010                 1015                 1020             


Phe Pro  Gln Tyr Phe Ala Val  Val Ser Arg Ile Lys  Gln Asp Ser 
    1025                 1030                 1035             


Asn Leu  Ile Gly Pro Glu Gly  Gly Val Leu Ser Ser  Thr Val Val 
    1040                 1045                 1050             


Pro Gln  Val Gln Ala Val Phe  Pro Glu Gly Ala Leu  Thr Lys Arg 
    1055                 1060                 1065             


Ile Arg  Val Gly Leu Gln Ala  Gln Pro Met His Ser  Glu Leu Val 
    1070                 1075                 1080             


Lys Lys  Ile Leu Gly Asn Lys  Ala Thr Phe Ser Pro  Ile Val Thr 
    1085                 1090                 1095             


Leu Glu  Pro Arg Arg Arg Lys  Phe His Lys Pro Ile  Thr Met Thr 
    1100                 1105                 1110             


Ile Pro  Val Pro Lys Ala Ser  Ser Asp Val Met Leu  Asn Gly Phe 
    1115                 1120                 1125             


Gly Gly  Asp Ala Pro Thr Leu  Arg Leu Leu Cys Ser  Ile Thr Gly 
    1130                 1135                 1140             


Gly Thr  Thr Pro Ala Gln Trp  Glu Asp Ile Thr Gly  Thr Thr Pro 
    1145                 1150                 1155             


Leu Thr  Phe Val Asn Glu Cys  Val Ser Phe Thr Thr  Asn Val Ser 
    1160                 1165                 1170             


Ala Arg  Phe Trp Leu Ile Asp  Cys Arg Gln Ile Gln  Glu Ser Val 
    1175                 1180                 1185             


Thr Phe  Ala Ser Gln Val Tyr  Arg Glu Ile Ile Cys  Val Pro Tyr 
    1190                 1195                 1200             


Met Ala  Lys Phe Val Val Phe  Ala Lys Ser His Asp  Pro Ile Glu 
    1205                 1210                 1215             


Ala Arg  Leu Arg Cys Phe Cys  Met Thr Asp Asp Lys  Val Asp Lys 
    1220                 1225                 1230             


Thr Leu  Glu Gln Gln Glu Asn  Phe Ala Glu Val Ala  Arg Ser Arg 
    1235                 1240                 1245             


Asp Val  Glu Val Leu Glu Gly  Lys Pro Ile Tyr Val  Asp Cys Phe 
    1250                 1255                 1260             


Gly Asn  Leu Val Pro Leu Thr  Lys Ser Gly Gln His  His Ile Phe 
    1265                 1270                 1275             


Ser Phe  Phe Ala Phe Lys Glu  Asn Arg Leu Pro Leu  Phe Val Lys 
    1280                 1285                 1290             


Val Arg  Asp Thr Thr Gln Glu  Pro Cys Gly Arg Leu  Ser Phe Met 
    1295                 1300                 1305             


Lys Glu  Pro Lys Ser Thr Arg  Gly Leu Val His Gln  Ala Ile Cys 
    1310                 1315                 1320             


Asn Leu  Asn Ile Thr Leu Pro  Ile Tyr Thr Lys Glu  Ser Glu Ser 
    1325                 1330                 1335             


Asp Gln  Glu Gln Glu Glu Glu  Ile Asp Met Thr Ser  Glu Lys Asn 
    1340                 1345                 1350             


Pro Gln  Asp Glu Gln Glu Arg  Ile Glu Glu Arg Leu  Ala Tyr Ile 
    1355                 1360                 1365             


Ala Asp  His Leu Gly Phe Ser  Trp Thr Glu Leu Ala  Arg Glu Leu 
    1370                 1375                 1380             


Asp Phe  Thr Glu Glu Gln Ile  His Gln Ile Arg Ile  Glu Asn Pro 
    1385                 1390                 1395             


Asn Ser  Leu Gln Asp Gln Ser  His Ala Leu Leu Lys  Tyr Trp Leu 
    1400                 1405                 1410             


Glu Arg  Asp Gly Lys His Ala  Thr Asp Thr Asn Leu  Val Glu Cys 
    1415                 1420                 1425             


Leu Thr  Lys Ile Asn Arg Met  Asp Ile Val His Leu  Met Glu Thr 
    1430                 1435                 1440             


Asn Thr  Glu Pro Leu Gln Glu  Arg Ile Ser His Ser  Tyr Ala Glu 
    1445                 1450                 1455             


Ile Glu  Gln Thr Ile Thr Leu  Asp His Ser Glu Gly  Phe Ser Val 
    1460                 1465                 1470             


Leu Gln  Glu Glu Leu Cys Thr  Ala Gln His Lys Gln  Lys Glu Glu 
    1475                 1480                 1485             


Gln Ala  Val Ser Lys Glu Ser  Glu Thr Cys Asp His  Pro Pro Ile 
    1490                 1495                 1500             


Val Ser  Glu Glu Asp Ile Ser  Val Gly Tyr Ser Thr  Phe Gln Asp 
    1505                 1510                 1515             


Gly Val  Pro Lys Thr Glu Gly  Asp Ser Ser Ala Thr  Ala Leu Phe 
    1520                 1525                 1530             


Pro Gln  Thr His Lys Glu Gln  Val Gln Gln Asp Phe  Ser Gly Lys 
    1535                 1540                 1545             


Met Gln  Asp Leu Pro Glu Glu  Ser Ser Leu Glu Tyr  Gln Gln Glu 
    1550                 1555                 1560             


Tyr Phe  Val Thr Thr Pro Gly  Thr Glu Thr Ser Glu  Thr Gln Lys 
    1565                 1570                 1575             


Ala Met  Ile Val Pro Ser Ser  Pro Ser Lys Thr Pro  Glu Glu Val 
    1580                 1585                 1590             


Ser Thr  Pro Ala Glu Glu Glu  Lys Leu Tyr Leu Gln  Thr Pro Thr 
    1595                 1600                 1605             


Ser Ser  Glu Arg Gly Gly Ser  Pro Ile Ile Gln Glu  Pro Glu Glu 
    1610                 1615                 1620             


Pro Ser  Glu His Arg Glu Glu  Ser Ser Pro Arg Lys  Thr Ser Leu 
    1625                 1630                 1635             


Val Ile  Val Glu Ser Ala Asp  Asn Gln Pro Glu Thr  Cys Glu Arg 
    1640                 1645                 1650             


Leu Asp  Glu Asp Ala Ala Phe  Glu Lys Gly Asp Asp  Met Pro Glu 
    1655                 1660                 1665             


Ile Pro  Pro Glu Thr Val Thr  Glu Glu Glu Tyr Ile  Asp Glu His 
    1670                 1675                 1680             


Gly His  Thr Val Val Lys Lys  Val Thr Arg Lys Ile  Ile Arg Arg 
    1685                 1690                 1695             


Tyr Val  Ser Ser Glu Gly Thr  Glu Lys Glu Glu Ile  Met Val Gln 
    1700                 1705                 1710             


Gly Met  Pro Gln Glu Pro Val  Asn Ile Glu Glu Gly  Asp Gly Tyr 
    1715                 1720                 1725             


Ser Lys  Val Ile Lys Arg Val  Val Leu Lys Ser Asp  Thr Glu Gln 
    1730                 1735                 1740             


Ser Glu  Asp Asn Asn Glu 
    1745                 

<210>  2016
<211>  14340
<212>  DNA
<213>  Homo sapiens

<400>  2016
agatttaaca atgcagtcag ataaacagtt gtggcagctg ctgccatggc aacgtcaccg     60

tccttaccct cccagtgcgc gccccttccc cacccctcct cctcctcctg ctttcctcca    120

gtaagtgcat acccgctagt ggtctgtaca ggcggcacgg tttgatggca gagatatttt    180

ctttccaaac tgttcaaaat gatgaacgaa gatgcagctc agaaaagcga cagtggagag    240

aagttcaacg gcagtagtca gaggagaaaa agacccaaga agtctgacag caatgcaagc    300

ttcctccgtg ctgccagagc aggcaacctg gacaaagttg tggaatatct gaaggggggc    360

atagacatca atacctgcaa tcagaatgga ctcaacgctc tccatctggc tgccaaggaa    420

ggccacgtgg ggctggtgca ggagctgctg ggaagagggt cctctgtgga ttctgccact    480

aagaagggaa ataccgctct tcacattgca tctttggctg gacaagcaga agttgtcaaa    540

gttcttgtta aggaaggagc caatattaat gcacagtctc agaatggctt tactccttta    600

tacatggctg cccaagagaa tcacattgat gttgtaaaat atttgctgga aaatggagct    660

aatcagagca ctgctacaga ggatggcttt actcctctag ctgtggcact ccagcaagga    720

cacaaccagg cggtggccat cctcttggag aatgacacca aagggaaagt gaggctgcca    780

gctctgcata ttgccgctag gaaagacgac accaaatctg ccgcacttct gcttcagaat    840

gaccacaatg ctgacgtaca atccaagatg atggtgaata ggacaactga gagtggtttt    900

acccctttgc acatagctgc acattacgga aatgtcaacg tggcaactct tcttctaaac    960

cggggagctg ctgtggactt cacagccagg aatggaatca ctcctctgca tgtggcttcc   1020

aaaagaggaa atacaaacat ggtgaagctc ttactggatc gaggcggtca gatcgatgcc   1080

aaaactaggg atgggttgac accacttcac tgtgctgcac gaagtgggca tgaccaagtg   1140

gtggaacttc tgttggaacg gggtgccccc ttgctggcaa ggactaagaa tgggctgtct   1200

ccactacaca tggctgccca gggagaccac gtggaatgtg tgaagcacct gttacagcac   1260

aaggcacctg ttgatgatgt caccctagac tacctgacag ccctccacgt tgctgcgcac   1320

tgtggccact accgtgtaac caaactcctt ttagacaaga gagccaatcc gaacgccaga   1380

gccctgaatg gttttactcc actgcacatt gcctgcaaga aaaaccgcat caaagtcatg   1440

gaactgctgg tgaaatatgg ggcttcaatc caagctataa cagagtctgg cctcacacca   1500

atacatgtgg ctgccttcat gggccacttg aacattgtcc tccttctgct gcagaacgga   1560

gcctctccag atgtcactaa cattcgtggt gagacggcac tacacatggc agcccgagcc   1620

gggcaggtgg aagtggtccg atgcctcctg agaaatggtg cccttgttga tgccagagcc   1680

agggaggaac agacaccttt acatattgcc tcccgcctgg gtaagacaga aattgtccag   1740

ctgcttctac aacatatggc tcatccagat gcggccacta caaatgggta cacaccactg   1800

cacatctctg cccgggaggg ccaggtggat gtggcatcag tcctattgga agcaggagca   1860

gcccactcct tagctaccaa gaagggtttt actcccctgc atgtagcagc caagtatgga   1920

agcctggatg tggcaaaact tctcttgcaa cgccgtgctg ccgcagattc tgcagggaag   1980

aacggcctta ccccgctcca tgttgctgct cattatgaca accagaaggt ggcgctgctg   2040

ttactggaga agggtgcttc ccctcatgcc actgccaaga atggctatac tccgttacat   2100

attgctgcca agaagaatca aatgcagata gcttccacac tcctgaacta tggagcagag   2160

acaaacattg tgacaaagca aggagtaact ccactccatc tggcctcgca ggaggggcac   2220

acagatatgg ttaccttgct tctggataag ggagccaata tccacatgtc aactaagagt   2280

ggactcacat ccttacacct tgcagcccag gaagataaag tgaatgttgc tgatattctc   2340

accaagcatg gagctgatca ggatgctcat acaaagcttg gttacacacc tttaattgtg   2400

gcctgtcact atggaaatgt gaaaatggtc aactttcttc tgaagcaggg agcaaatgtt   2460

aacgcaaaaa ccaagaacgg ctacacgcct ttgcaccagg ccgctcagca gggtcacacg   2520

cacatcatca acgtcctgct ccagcatggg gccaagccca acgccaccac tgcgaatggc   2580

aacactgcct tggcgattgc taagcgtctg ggctacatct ccgtggtcga caccctgaag   2640

gttgtgactg aggaggtcac caccaccacc acaactatta cagaaaaaca caaactaaat   2700

gtacctgaga cgatgactga ggttcttgat gtttctgatg aagagggtga tgacacaatg   2760

actggtgatg ggggagaata ccttaggcct gaggacctaa aagaactggg tgatgactca   2820

ctacccagca gtcagttcct ggatggtatg aattacctgc gatacagctt ggagggagga   2880

cgatctgaca gccttcgatc cttcagttcc gacaggtctc acactctgag ccatgcctcc   2940

tacctgaggg acagtgccgt gatggatgac tcagttgtga ttcccagtca ccaggtgtca   3000

actctagcca aggaggcaga aaggaattct tatcgcctaa gctggggcac tgagaactta   3060

gacaacgtgg ctctttcttc tagtcctatt cattcaggtt tcctggttag ttttatggtg   3120

gatgcccgag gtggtgctat gcgaggatgc agacacaatg ggctccgaat cattattcca   3180

cctcggaaat gtactgctcc aacgcgagtc acctgccgac tggtcaagcg ccacagactg   3240

gcaacaatgc ctccaatggt ggaaggagaa ggcctggcca gtcgcctgat cgaagttgga   3300

ccttctggtg ctcagttcct tggtaaactt cacctgccaa cggctcctcc cccacttaat   3360

gagggagaaa gtttggtcag ccgcattctt cagctggggc ctcctggaac caaattcctt   3420

gggcctgtga tcgtggagat ccctcacttt gcggcccttc gaggaaagga aagggaactg   3480

gtggtcctgc gcagtgagaa tggggacagc tggaaagagc atttctgtga ctacactgaa   3540

gatgaattga atgaaattct taacggcatg gatgaagtac tggatagccc agaagaccta   3600

gaaaagaaac gaatctgccg catcatcacc cgagacttcc cacagtactt tgcagtggtg   3660

tctcgtatca aacaggacag caatctgatt ggcccagaag gaggtgtact gagcagcaca   3720

gtggtgcccc aggtgcaggc cgtcttccca gagggggcac tcaccaagcg gatccgcgta   3780

ggcctgcagg ctcaacctat gcacagtgag ctggttaaga agatcctagg caacaaagct   3840

accttcagcc ctatagtcac tttggaacct agaagaagaa aattccacaa accaattacc   3900

atgaccattc ctgtccccaa agcttcaagt gatgtcatgt tgaatggttt tgggggagat   3960

gcaccaacct taagattact atgcagcata acaggtggaa ccacccctgc ccagtgggaa   4020

gatattacag gaactacgcc attaacattt gtcaatgaat gtgtttcctt tacaacaaac   4080

gtgtctgcca ggttctggct gatagattgt cgacagatcc aggaatccgt tacttttgca   4140

tcacaagtat acagagaaat tatctgcgta ccttatatgg ccaaatttgt agtgtttgcc   4200

aaatcacatg accccattga agccaggttg aggtgtttct gcatgactga tgataaagtg   4260

gataagaccc ttgaacaaca agaaaatttt gctgaggtgg ccagaagcag ggatgtggag   4320

gtgttagaag gaaaacccat ctacgttgat tgtttcggca acttggtacc attaactaaa   4380

agtggccagc atcatatatt cagttttttt gccttcaaag aaaatagact tcctctattt   4440

gtcaaggtac gcgatacgac tcaggaacct tgcggacgac tatcatttat gaaggagcca   4500

aaatccacga gaggcctggt gcatcaagct atttgcaact taaacatcac tttgccgatt   4560

tatacaaagg aatcagagtc agatcaagaa caggaggaag agatcgatat gacatcagaa   4620

aaaaatgatg agacagaatc tacagaaaca tctgtcctga aaagtcacct ggttaatgaa   4680

gttcctgtcc tagcaagtcc ggacttgctc tctgaagttt ctgagatgaa acaagatttg   4740

atcaaaatga ccgccatctt gaccacagat gtgtctgata aggcaggttc tattaaagtg   4800

aaggagctgg tgaaggctgc tgaggaagag ccaggagagc cttttgaaat cgttgaaaga   4860

gttaaagagg acttagagaa agtgaatgaa atcctgagaa gtggaacctg cacaagagat   4920

gaaagcagtg tgcagagctc tcggtctgag agaggattag ttgaagagga atgggttatt   4980

gtcagtgatg aggaaataga agaggctagg caaaaagcac ctttagaaat cactgaatat   5040

ccatgtgtag aagttagaat agataaagag atcaaaggaa aagtagagaa agactcaact   5100

gggctagtga actaccttac tgatgatctg aatacctgtg tgcctcttcc caaagagcag   5160

ctgcagacag ttcaagataa ggcagggaag aaatgtgagg ctctggctgt tggcaggagc   5220

tctgaaaagg aagggaaaga cataccccca gatgagacac agagtacaca gaaacagcac   5280

aaaccaagct tgggaataaa gaagccagta agaaggaaat taaaagaaaa gcagaaacaa   5340

aaagaggaag gtttacaagc tagtgcagag aaagctgaac ttaaaaaagg tagttcagaa   5400

gagtcattag gtgaagaccc aggtttagcc cctgaacccc ttcccactgt caaggccaca   5460

tctcctttga tagaagaaac tcccattggt tccataaagg acaaagtaaa ggcccttcag   5520

aagcgagtgg aagatgaaca gaaaggtcga agcaagttgc ccatcagagt caaaggcaag   5580

gaggacgtgc caaaaaagac cacccacagg ccacatccag ctgcgtcacc ctctctgaag   5640

tcagagagac atgcgccagg gtctccctcc cctaaaacag aaagacactc tactctttcc   5700

tcttccgcaa aaactgaaag gcaccctcca gtatcaccat caagtaaaac tgagaaacac   5760

tcacctgtgt caccctctgc aaaaacggaa agacattcac ctgcgtcatc atcgagtaaa   5820

actgagaaac actcacctgt atcaccctcg acaaaaactg aaaggcactc tcctgtgtca   5880

tctacaaaaa cagaaagaca cccacctgtt tcgccttcag gcaaaacaga caaacgtcca   5940

cctgtatcgc cctccgggag gacagaaaaa cacccgccag tatcgcctgg gagaacagaa   6000

aaacgcttgc ctgtttcacc ctccggaaga acggacaagc accaacctgt atcaacagct   6060

gggaaaactg agaagcacct gcctgtgtca ccttctggca aaacagaaaa gcaaccacct   6120

gtatccccca cttcaaaaac agagaggatt gaggaaacca tgtctgttcg ggagctgatg   6180

aaggctttcc agtcaggtca ggacccttct aaacataaaa ctggactctt tgagcacaaa   6240

tcagcaaaac aaaagcagcc acaagagaaa ggtaaagttc gggtagaaaa agaaaagggg   6300

ccgatactaa cccagagaga agctcagaaa acagagaatc agacaatcaa acgaggccag   6360

agactcccgg taacgggcac agcagaatcc aaaagaggag ttcgtgtttc ctccatagga   6420

gttaagaaag aagatgcagc tggaggaaag gagaaagttc tcagccacaa aatacctgaa   6480

cctgttcagt cagtgcctga agaagaaagc cacagagaga gcgaagtgcc caaagaaaag   6540

atggctgatg agcagggaga catggatcta cagatcagcc cagataggaa aacctccact   6600

gacttctctg aggtcattaa gcaagagttg gaagacaatg acaaatacca acaattccgc   6660

ctgagtgagg agacagaaaa ggcacagctt cacttagacc aagtactcac tagtcctttc   6720

aacacaacat ttccactcga ctacatgaaa gatgagttcc ttccagctct gtctttacaa   6780

agcggtgctt tagatggcag ttctgaaagc ctaaagaatg agggggtagc cggctctccg   6840

tgtggcagcc tgatggaggg gacccctcag attagttcag aagaaagcta taagcatgaa   6900

ggcctagcag agacccctga gacgagccca gaaagccttt ctttctcacc aaagaaaagt   6960

gaggagcaaa ctggggaaac aaaggaaagc accaagacag aaaccaccac agaaattcgt   7020

tcagaaaaag agcatcccac gaccaaagac attactggtg gctctgaaga gcgaggtgcc   7080

acagtcactg aggactcaga gacctctact gagagttttc agaaagaggc cactctaggc   7140

tctcccaaag acacaagccc taaaagacaa gatgattgca caggcagctg tagtgtagca   7200

ttagctaaag agacacctac aggactgact gaggaggcag cctgtgatga aggtcaacgt   7260

acctttggta gttcagccca caagacacaa actgatagtg aggttcaaga atccacagcc   7320

acctcagacg agacaaaggc cttgccgctg cctgaggctt ctgtaaagac agatacagga   7380

actgaatcaa aacctcaggg agtcattaga agtccccaag ggttagaact tgcactccct   7440

agccgagata gcgaagtcct cagcgctgtg gctgatgact cattagcagt gagccacaaa   7500

gactctctgg aagccagccc tgtgctagaa gataactctt cacacaaaac ccctgattct   7560

ctggagccaa gtcctctgaa agaatcccct tgccgtgact ctctggaaag cagccctgtt   7620

gaaccaaaga tgaaggctgg aatttttcca agtcactttc ctcttcctgc agctgttgcc   7680

aaaacagaac tcttgacgga agtggcctct gtgcggtccc ggctactccg agaccctgat   7740

ggcagtgctg aggatgacag tcttgagcag acatcgctca tggagagctc agggaagagc   7800

cccctttctc ctgacacccc cagctctgaa gaagtcagct atgaggttac acccaaaacc   7860

acagatgtaa gtacaccaaa accagctgtg attcatgaat gtgcagagga ggatgattca   7920

gaaaacgggg agaaaaagag gttcacacct gaagaggaga tgtttaaaat ggtaaccaaa   7980

atcaaaatgt ttgatgaact tgaacaagaa gcaaagcaga aaagggacta caaaaaagaa   8040

cccaaacaag aagaatcttc ttcatcttct gacccagatg ctgactgttc agtagatgtg   8100

gatgaaccaa aacatacagg cagtggggag gatgaaagtg gtgtccctgt gttagtaact   8160

tcggagagca ggaaggtgtc ttcctcctca gaaagtgaac ctgagttggc acagcttaaa   8220

aaaggtgctg actcaggcct tttaccagaa ccagtgattc gagtacaacc tccttctcca   8280

cttccatcaa gcatggactc caattccagt ccagaagaag tacaattcca gcctgtcgtt   8340

tccaaacaat atactttcaa gatgaatgaa gatactcagg aagagccagg caaatcagaa   8400

gaagaaaaag attctgaatc ccatttagct gaagaccgtc atgctgtttc cactgaggct   8460

gaagacaggt cttatgataa gctaaacaga gacactgatc agccaaaaat ctgtgatggc   8520

catggatgtg aggccatgag tcctagcagc tcagctgctc ctgtctcttc aggtctacag   8580

agtccgactg gtgatgatgt tgatgaacag ccagtcatct ataaagaatc attagctctc   8640

caaggcactc atgaaaaaga cacagaggga gaagagcttg atgtttctag agcagaatct   8700

ccacaagcag attgccccag tgaaagcttt tcatcttcat cctctttgcc tcattgtttg   8760

gtatctgaag gaaaagaatt agatgaagac atatctgcca catcttctat tcaaaaaaca   8820

gaggtcacaa aaactgatga aacatttgag aacttaccaa aggactgccc ctctcaagac   8880

tcatccatta ctactcaaac agatagattt tccatggatg ttcccgtgtc tgacctagct   8940

gagaatgatg aaatctatga tccacaaatc actagccctt atgaaaatgt cccttcccaa   9000

tcttttttct ctagtgaaga aagcaaaacc caaacagatg caaatcacac cacaagtttt   9060

cactcttctg aagtgtattc tgttaccatc acatcccctg ttgaagacgt tgtagtggca   9120

agctcctcta gtggaactgt tttaagcaaa gaatctaatt ttgagggcca ggacataaaa   9180

atggaatccc aacaggaaag taccttgtgg gaaatgcaat cagacagtgt ctcttcatct   9240

ttcgagccta ctatgtccgc tacaacaaca gttgttggtg aacaaataag caaagtcatc   9300

atcacaaaaa ctgatgtgga ttctgattct tggagtgaaa ttcgggaaga cgatgaagcc   9360

tttgaggctc gtgtgaaaga ggaagaacaa aagatatttg gtttgatggt agacagacaa   9420

tcacagggta ccacccctga caccactcct gctaggaccc caactgaaga ggggacccca   9480

acaagtgagc aaaacccatt tctgtttcag gaaggaaaat tgtttgaaat gacccgaagt   9540

ggtgccattg atatgaccaa aaggtcctat gcagatgaaa gttttcactt tttccaaatt   9600

ggtcaagaat ccagggaaga gactctctct gaagatgtga aagaaggggc tactggggct   9660

gatcccctac cgctggagac atcagctgaa tcactagcac tttcagaatc aaaagaaaca   9720

gtggatgatg aggcagactt acttccagat gacgtgagtg aggaagtaga ggaaatacct   9780

gcttcggatg ctcaacttaa ctcccaaatg gggatttcag cctccactga aacacctaca   9840

aaagaagctg ttagtgtagg gaccaaggac ctccccaccg tgcaaacggg tgatatacct   9900

cctctctctg gtgtaaagca gatatcctgc cccgactctt ctgaaccagc tgtacaagtc   9960

cagttagatt tttccacact caccaggtct gtttattcag ataggggtga tgattctccc  10020

gattcttccc cagaagaaca gaaatcagta atcgagattc ctactgcacc catggagaat  10080

gtgcctttta ctgaaagcaa atccaaaatt cctgtaagga ctatgcccac ttccacccca  10140

gcacctccat ctgcagagta tgagagttca gtttctgaag attttctatc cagtgtagat  10200

gaggaaaata aggcggatga agcaaaacca aagtccaaac tccctgtcaa agtacccctc  10260

caaagagttg aacagcagct ctcagatcta gacacctctg tccagaagac agtggctcct  10320

cagggacagg acatggcaag catcgcacca gataatagaa gcaaatctga atctgatgct  10380

agttctttgg attcaaagac caaatgccca gtaaaaaccc gaagttacac tgagacagaa  10440

acagagagca gagagagggc cgaggaactt gagttagaat cagaagaagg ggccacaaga  10500

ccaaagatac ttacatcccg attgccagtt aagagcagaa gcactacatc ttcctgcagg  10560

gggggcacga gccccacaaa agaaagtaag gagcatttct ttgaccttta cagaaattcc  10620

atagaattct ttgaggagat tagtgatgag gcttccaaat tagtggatag gctgacacag  10680

tcagagaggg agcaggaaat agtttcagac gatgaaagta gtagtgccct ggaagtatca  10740

gtaattgaaa atctgccacc tgttgagacc gagcactcag ttcctgagga catctttgac  10800

acaaggccca tttgggatga gtctattgag actctgattg aacgcatccc tgatgaaaat  10860

ggccatgacc atgctgaaga tccacaggat gagcaggaac ggatcgagga aaggctggct  10920

tatattgctg atcaccttgg cttcagctgg acagaattag caagagaact ggatttcact  10980

gaggagcaaa ttcatcaaat tcgaattgaa aatcccaact ctcttcaaga ccagagtcat  11040

gcactgttga agtactggct agagagggat gggaaacatg ctacagatac caacctcgtt  11100

gaatgtctca ccaagatcaa ccgaatggat attgttcatc tcatggagac caacacagaa  11160

cctctccagg agcgcatcag tcatagttat gcagaaattg aacagaccat tacactggat  11220

catagtgaag ggttctcggt acttcaagag gagttatgca ctgcacagca caagcagaaa  11280

gaggagcaag ctgtttctaa agaaagtgag acctgcgatc accctcctat cgtctcagag  11340

gaagacattt ctgttggtta ttccactttt caggatggcg tccccaaaac tgagggggac  11400

agctcagcaa cagcactctt tccccaaact cacaaggagc aagttcaaca ggatttctca  11460

gggaaaatgc aagacctgcc tgaagagtca tctctggaat atcagcagga atattttgtg  11520

acaactccag gaacagaaac atcagagact cagaaggcta tgatagtacc cagctctccc  11580

agcaagacac ctgaggaagt tagcacccct gcagaggagg agaagctgta cctccagacc  11640

ccaacatcca gcgagcgggg aggctctccc atcatacaag aacccgaaga gccctcagag  11700

cacagagagg agagctctcc gcggaaaacc agcctcgtaa tagtggagtc tgccgataac  11760

cagcctgaga cctgtgaaag actcgatgaa gatgcagctt ttgaaaaggg agacgatatg  11820

cctgaaatac ccccagaaac agtcacagaa gaagaataca ttgatgagca tggacacacc  11880

gtggtaaaga aggttactag gaaaatcatt aggcggtatg tatcctctga aggcacagag  11940

aaagaagaga ttatggtgca gggaatgcca caggaacctg tcaacatcga ggaaggggat  12000

ggctattcca aagttataaa gcgtgttgta ttgaagagtg acaccgagca gtcagaggac  12060

aacaatgagt aaagccatca cacagaagag ggctgtggtg aaggaccagc atggaaaacg  12120

cattgacttg gagcacctgg aggatgtacc agaagcacta gaccaggacg acctccagcg  12180

cgatctccag cagctccttc ggcatttctg caaggaggac ttgaagcaag aggccaagtg  12240

aggggctgcc cagttctcac accagaaacc acacattcac tcaatatgca gcttcctgtt  12300

tcagtagggg agtgacctaa ctggcctaat taatgggata ccccgacatt tccactgtta  12360

gcaaatatac ggcattttgc tttagttttc ccccatcctc tttaactata aagctaattt  12420

gtgaccaaag atggcatcct tcatactgga tgctgtatcc aatactttgt tgtgtctgtg  12480

ctaacctggg aactggccac ctccattgtt ctttgcttct gcacaagatc catgaaaatc  12540

cattgatcag aagaacttca cctgcagacc tcttcaagtg acactatgta ggaatccttc  12600

caaggaatat ctatgtacaa tgtatatagc tgaaatgctc agatgaacaa catattaaaa  12660

ttaaaaccac tgcctattgt aactacactg ggcatcagaa taaaaggcct ctagaaattg  12720

ctgaacaatg gttaattaag atattgctaa cacaatcgag tgataataca gttttactgc  12780

aaaagaagca cttcaaacct attatgtcct tagaacttcc agagtagcca ctgctcccag  12840

ttaaaggtgg gtcagtagcc ttgcagaact gtcctgagaa gttattgctg gtgctggcca  12900

gccatggctt aggactccaa cagccactct gagggagggg agaagggagc agaggccacg  12960

cagaatgaac cgatggggta ttcagttgct ggcagctaca ttgtgtggca ttctagcatc  13020

ttcaggtctt tagatcttgg acaagttggc agggtatttt aaaagctata actactgtag  13080

ttttccagtt ttcattgctg ctttagcaaa ccacgctgtc ttacagtggt actttcttct  13140

ggccactgca ctgtagataa ttcattggaa acaagattta cccactacat aaaaggttaa  13200

actccttcag tatgttggag tggtttcttt ttttttttct ttctttcttt tttttcttca  13260

ggtttatatc ttctctaata cctgcatgtg gcgtttaaaa atcaagacca cggtcaaacc  13320

cctcttctaa tcacattaat tgtttccatt ctttttaccc tgagtgagca cttttcactt  13380

tccagctagg tctgtttttc agcttgcaga caagattgag aaatccttga aaatttggtt  13440

ttggttaaaa tttttggttt atttatttga aatccacact cccttggaaa ctcttaagtg  13500

catttgtgca cttctgtttg tttgtctcaa agaagggact gtaacaatct gagtaatttc  13560

catgtcctct tccttattcc tctagtggtt gaagctgtgt agcattttaa catatatata  13620

ttcacaaata tattcatata aacagtatac attttgaatc agtcatttgt taaagaaaag  13680

tatattcaat gaagatgaaa tttaaataaa aaaggacaga gtctatcctc cagggattga  13740

acattttcca attatctggt cttttcctgt tgtgcaaaaa tgactcattg ctccgaatgt  13800

caaaaacaaa tgcgacaaac aatggcactt catcatttaa agtaatgttg ccaagagaaa  13860

aaatttcctg ggagggaggt ttcccacaag ccaaatctcc taagcctcaa atgctagcac  13920

tttttggcag ttggatagga aatgagacat tctttggcag ccaaaataag agaggccgat  13980

ggtgaaactt tttgagacac cctatggcct tcttgtcaaa accttcactg gagctcaaga  14040

aaagcatttc tgttgtgtta tttgcagtgc agatgatgtc tgtgtaacaa cataatggtt  14100

attcaccttt ttttgatttt gatttttgct gtgttatcaa aaacttgaat actgtgagaa  14160

gaagtgaatt ttcagttgac gaatcagcat cttgttccca tggtgataac actaattgaa  14220

tatatctatg agggcatgta ttagttaatg gaaaaaaaaa tacaacacta acaatacata  14280

gctgcaatgt gtacaatggc tgatttaatt aaataaaatg tacaagtgtt aaatgtggca  14340


<210>  2017
<211>  3957
<212>  PRT
<213>  Homo sapiens

<400>  2017


Met Met Asn Glu Asp Ala Ala Gln Lys Ser Asp Ser Gly Glu Lys Phe 
1               5                   10                  15      


Asn Gly Ser Ser Gln Arg Arg Lys Arg Pro Lys Lys Ser Asp Ser Asn 
            20                  25                  30          


Ala Ser Phe Leu Arg Ala Ala Arg Ala Gly Asn Leu Asp Lys Val Val 
        35                  40                  45              


Glu Tyr Leu Lys Gly Gly Ile Asp Ile Asn Thr Cys Asn Gln Asn Gly 
    50                  55                  60                  


Leu Asn Ala Leu His Leu Ala Ala Lys Glu Gly His Val Gly Leu Val 
65                  70                  75                  80  


Gln Glu Leu Leu Gly Arg Gly Ser Ser Val Asp Ser Ala Thr Lys Lys 
                85                  90                  95      


Gly Asn Thr Ala Leu His Ile Ala Ser Leu Ala Gly Gln Ala Glu Val 
            100                 105                 110         


Val Lys Val Leu Val Lys Glu Gly Ala Asn Ile Asn Ala Gln Ser Gln 
        115                 120                 125             


Asn Gly Phe Thr Pro Leu Tyr Met Ala Ala Gln Glu Asn His Ile Asp 
    130                 135                 140                 


Val Val Lys Tyr Leu Leu Glu Asn Gly Ala Asn Gln Ser Thr Ala Thr 
145                 150                 155                 160 


Glu Asp Gly Phe Thr Pro Leu Ala Val Ala Leu Gln Gln Gly His Asn 
                165                 170                 175     


Gln Ala Val Ala Ile Leu Leu Glu Asn Asp Thr Lys Gly Lys Val Arg 
            180                 185                 190         


Leu Pro Ala Leu His Ile Ala Ala Arg Lys Asp Asp Thr Lys Ser Ala 
        195                 200                 205             


Ala Leu Leu Leu Gln Asn Asp His Asn Ala Asp Val Gln Ser Lys Met 
    210                 215                 220                 


Met Val Asn Arg Thr Thr Glu Ser Gly Phe Thr Pro Leu His Ile Ala 
225                 230                 235                 240 


Ala His Tyr Gly Asn Val Asn Val Ala Thr Leu Leu Leu Asn Arg Gly 
                245                 250                 255     


Ala Ala Val Asp Phe Thr Ala Arg Asn Gly Ile Thr Pro Leu His Val 
            260                 265                 270         


Ala Ser Lys Arg Gly Asn Thr Asn Met Val Lys Leu Leu Leu Asp Arg 
        275                 280                 285             


Gly Gly Gln Ile Asp Ala Lys Thr Arg Asp Gly Leu Thr Pro Leu His 
    290                 295                 300                 


Cys Ala Ala Arg Ser Gly His Asp Gln Val Val Glu Leu Leu Leu Glu 
305                 310                 315                 320 


Arg Gly Ala Pro Leu Leu Ala Arg Thr Lys Asn Gly Leu Ser Pro Leu 
                325                 330                 335     


His Met Ala Ala Gln Gly Asp His Val Glu Cys Val Lys His Leu Leu 
            340                 345                 350         


Gln His Lys Ala Pro Val Asp Asp Val Thr Leu Asp Tyr Leu Thr Ala 
        355                 360                 365             


Leu His Val Ala Ala His Cys Gly His Tyr Arg Val Thr Lys Leu Leu 
    370                 375                 380                 


Leu Asp Lys Arg Ala Asn Pro Asn Ala Arg Ala Leu Asn Gly Phe Thr 
385                 390                 395                 400 


Pro Leu His Ile Ala Cys Lys Lys Asn Arg Ile Lys Val Met Glu Leu 
                405                 410                 415     


Leu Val Lys Tyr Gly Ala Ser Ile Gln Ala Ile Thr Glu Ser Gly Leu 
            420                 425                 430         


Thr Pro Ile His Val Ala Ala Phe Met Gly His Leu Asn Ile Val Leu 
        435                 440                 445             


Leu Leu Leu Gln Asn Gly Ala Ser Pro Asp Val Thr Asn Ile Arg Gly 
    450                 455                 460                 


Glu Thr Ala Leu His Met Ala Ala Arg Ala Gly Gln Val Glu Val Val 
465                 470                 475                 480 


Arg Cys Leu Leu Arg Asn Gly Ala Leu Val Asp Ala Arg Ala Arg Glu 
                485                 490                 495     


Glu Gln Thr Pro Leu His Ile Ala Ser Arg Leu Gly Lys Thr Glu Ile 
            500                 505                 510         


Val Gln Leu Leu Leu Gln His Met Ala His Pro Asp Ala Ala Thr Thr 
        515                 520                 525             


Asn Gly Tyr Thr Pro Leu His Ile Ser Ala Arg Glu Gly Gln Val Asp 
    530                 535                 540                 


Val Ala Ser Val Leu Leu Glu Ala Gly Ala Ala His Ser Leu Ala Thr 
545                 550                 555                 560 


Lys Lys Gly Phe Thr Pro Leu His Val Ala Ala Lys Tyr Gly Ser Leu 
                565                 570                 575     


Asp Val Ala Lys Leu Leu Leu Gln Arg Arg Ala Ala Ala Asp Ser Ala 
            580                 585                 590         


Gly Lys Asn Gly Leu Thr Pro Leu His Val Ala Ala His Tyr Asp Asn 
        595                 600                 605             


Gln Lys Val Ala Leu Leu Leu Leu Glu Lys Gly Ala Ser Pro His Ala 
    610                 615                 620                 


Thr Ala Lys Asn Gly Tyr Thr Pro Leu His Ile Ala Ala Lys Lys Asn 
625                 630                 635                 640 


Gln Met Gln Ile Ala Ser Thr Leu Leu Asn Tyr Gly Ala Glu Thr Asn 
                645                 650                 655     


Ile Val Thr Lys Gln Gly Val Thr Pro Leu His Leu Ala Ser Gln Glu 
            660                 665                 670         


Gly His Thr Asp Met Val Thr Leu Leu Leu Asp Lys Gly Ala Asn Ile 
        675                 680                 685             


His Met Ser Thr Lys Ser Gly Leu Thr Ser Leu His Leu Ala Ala Gln 
    690                 695                 700                 


Glu Asp Lys Val Asn Val Ala Asp Ile Leu Thr Lys His Gly Ala Asp 
705                 710                 715                 720 


Gln Asp Ala His Thr Lys Leu Gly Tyr Thr Pro Leu Ile Val Ala Cys 
                725                 730                 735     


His Tyr Gly Asn Val Lys Met Val Asn Phe Leu Leu Lys Gln Gly Ala 
            740                 745                 750         


Asn Val Asn Ala Lys Thr Lys Asn Gly Tyr Thr Pro Leu His Gln Ala 
        755                 760                 765             


Ala Gln Gln Gly His Thr His Ile Ile Asn Val Leu Leu Gln His Gly 
    770                 775                 780                 


Ala Lys Pro Asn Ala Thr Thr Ala Asn Gly Asn Thr Ala Leu Ala Ile 
785                 790                 795                 800 


Ala Lys Arg Leu Gly Tyr Ile Ser Val Val Asp Thr Leu Lys Val Val 
                805                 810                 815     


Thr Glu Glu Val Thr Thr Thr Thr Thr Thr Ile Thr Glu Lys His Lys 
            820                 825                 830         


Leu Asn Val Pro Glu Thr Met Thr Glu Val Leu Asp Val Ser Asp Glu 
        835                 840                 845             


Glu Gly Asp Asp Thr Met Thr Gly Asp Gly Gly Glu Tyr Leu Arg Pro 
    850                 855                 860                 


Glu Asp Leu Lys Glu Leu Gly Asp Asp Ser Leu Pro Ser Ser Gln Phe 
865                 870                 875                 880 


Leu Asp Gly Met Asn Tyr Leu Arg Tyr Ser Leu Glu Gly Gly Arg Ser 
                885                 890                 895     


Asp Ser Leu Arg Ser Phe Ser Ser Asp Arg Ser His Thr Leu Ser His 
            900                 905                 910         


Ala Ser Tyr Leu Arg Asp Ser Ala Val Met Asp Asp Ser Val Val Ile 
        915                 920                 925             


Pro Ser His Gln Val Ser Thr Leu Ala Lys Glu Ala Glu Arg Asn Ser 
    930                 935                 940                 


Tyr Arg Leu Ser Trp Gly Thr Glu Asn Leu Asp Asn Val Ala Leu Ser 
945                 950                 955                 960 


Ser Ser Pro Ile His Ser Gly Phe Leu Val Ser Phe Met Val Asp Ala 
                965                 970                 975     


Arg Gly Gly Ala Met Arg Gly Cys Arg His Asn Gly Leu Arg Ile Ile 
            980                 985                 990         


Ile Pro Pro Arg Lys Cys Thr Ala  Pro Thr Arg Val Thr  Cys Arg Leu 
        995                 1000                 1005             


Val Lys  Arg His Arg Leu Ala  Thr Met Pro Pro Met  Val Glu Gly 
    1010                 1015                 1020             


Glu Gly  Leu Ala Ser Arg Leu  Ile Glu Val Gly Pro  Ser Gly Ala 
    1025                 1030                 1035             


Gln Phe  Leu Gly Lys Leu His  Leu Pro Thr Ala Pro  Pro Pro Leu 
    1040                 1045                 1050             


Asn Glu  Gly Glu Ser Leu Val  Ser Arg Ile Leu Gln  Leu Gly Pro 
    1055                 1060                 1065             


Pro Gly  Thr Lys Phe Leu Gly  Pro Val Ile Val Glu  Ile Pro His 
    1070                 1075                 1080             


Phe Ala  Ala Leu Arg Gly Lys  Glu Arg Glu Leu Val  Val Leu Arg 
    1085                 1090                 1095             


Ser Glu  Asn Gly Asp Ser Trp  Lys Glu His Phe Cys  Asp Tyr Thr 
    1100                 1105                 1110             


Glu Asp  Glu Leu Asn Glu Ile  Leu Asn Gly Met Asp  Glu Val Leu 
    1115                 1120                 1125             


Asp Ser  Pro Glu Asp Leu Glu  Lys Lys Arg Ile Cys  Arg Ile Ile 
    1130                 1135                 1140             


Thr Arg  Asp Phe Pro Gln Tyr  Phe Ala Val Val Ser  Arg Ile Lys 
    1145                 1150                 1155             


Gln Asp  Ser Asn Leu Ile Gly  Pro Glu Gly Gly Val  Leu Ser Ser 
    1160                 1165                 1170             


Thr Val  Val Pro Gln Val Gln  Ala Val Phe Pro Glu  Gly Ala Leu 
    1175                 1180                 1185             


Thr Lys  Arg Ile Arg Val Gly  Leu Gln Ala Gln Pro  Met His Ser 
    1190                 1195                 1200             


Glu Leu  Val Lys Lys Ile Leu  Gly Asn Lys Ala Thr  Phe Ser Pro 
    1205                 1210                 1215             


Ile Val  Thr Leu Glu Pro Arg  Arg Arg Lys Phe His  Lys Pro Ile 
    1220                 1225                 1230             


Thr Met  Thr Ile Pro Val Pro  Lys Ala Ser Ser Asp  Val Met Leu 
    1235                 1240                 1245             


Asn Gly  Phe Gly Gly Asp Ala  Pro Thr Leu Arg Leu  Leu Cys Ser 
    1250                 1255                 1260             


Ile Thr  Gly Gly Thr Thr Pro  Ala Gln Trp Glu Asp  Ile Thr Gly 
    1265                 1270                 1275             


Thr Thr  Pro Leu Thr Phe Val  Asn Glu Cys Val Ser  Phe Thr Thr 
    1280                 1285                 1290             


Asn Val  Ser Ala Arg Phe Trp  Leu Ile Asp Cys Arg  Gln Ile Gln 
    1295                 1300                 1305             


Glu Ser  Val Thr Phe Ala Ser  Gln Val Tyr Arg Glu  Ile Ile Cys 
    1310                 1315                 1320             


Val Pro  Tyr Met Ala Lys Phe  Val Val Phe Ala Lys  Ser His Asp 
    1325                 1330                 1335             


Pro Ile  Glu Ala Arg Leu Arg  Cys Phe Cys Met Thr  Asp Asp Lys 
    1340                 1345                 1350             


Val Asp  Lys Thr Leu Glu Gln  Gln Glu Asn Phe Ala  Glu Val Ala 
    1355                 1360                 1365             


Arg Ser  Arg Asp Val Glu Val  Leu Glu Gly Lys Pro  Ile Tyr Val 
    1370                 1375                 1380             


Asp Cys  Phe Gly Asn Leu Val  Pro Leu Thr Lys Ser  Gly Gln His 
    1385                 1390                 1395             


His Ile  Phe Ser Phe Phe Ala  Phe Lys Glu Asn Arg  Leu Pro Leu 
    1400                 1405                 1410             


Phe Val  Lys Val Arg Asp Thr  Thr Gln Glu Pro Cys  Gly Arg Leu 
    1415                 1420                 1425             


Ser Phe  Met Lys Glu Pro Lys  Ser Thr Arg Gly Leu  Val His Gln 
    1430                 1435                 1440             


Ala Ile  Cys Asn Leu Asn Ile  Thr Leu Pro Ile Tyr  Thr Lys Glu 
    1445                 1450                 1455             


Ser Glu  Ser Asp Gln Glu Gln  Glu Glu Glu Ile Asp  Met Thr Ser 
    1460                 1465                 1470             


Glu Lys  Asn Asp Glu Thr Glu  Ser Thr Glu Thr Ser  Val Leu Lys 
    1475                 1480                 1485             


Ser His  Leu Val Asn Glu Val  Pro Val Leu Ala Ser  Pro Asp Leu 
    1490                 1495                 1500             


Leu Ser  Glu Val Ser Glu Met  Lys Gln Asp Leu Ile  Lys Met Thr 
    1505                 1510                 1515             


Ala Ile  Leu Thr Thr Asp Val  Ser Asp Lys Ala Gly  Ser Ile Lys 
    1520                 1525                 1530             


Val Lys  Glu Leu Val Lys Ala  Ala Glu Glu Glu Pro  Gly Glu Pro 
    1535                 1540                 1545             


Phe Glu  Ile Val Glu Arg Val  Lys Glu Asp Leu Glu  Lys Val Asn 
    1550                 1555                 1560             


Glu Ile  Leu Arg Ser Gly Thr  Cys Thr Arg Asp Glu  Ser Ser Val 
    1565                 1570                 1575             


Gln Ser  Ser Arg Ser Glu Arg  Gly Leu Val Glu Glu  Glu Trp Val 
    1580                 1585                 1590             


Ile Val  Ser Asp Glu Glu Ile  Glu Glu Ala Arg Gln  Lys Ala Pro 
    1595                 1600                 1605             


Leu Glu  Ile Thr Glu Tyr Pro  Cys Val Glu Val Arg  Ile Asp Lys 
    1610                 1615                 1620             


Glu Ile  Lys Gly Lys Val Glu  Lys Asp Ser Thr Gly  Leu Val Asn 
    1625                 1630                 1635             


Tyr Leu  Thr Asp Asp Leu Asn  Thr Cys Val Pro Leu  Pro Lys Glu 
    1640                 1645                 1650             


Gln Leu  Gln Thr Val Gln Asp  Lys Ala Gly Lys Lys  Cys Glu Ala 
    1655                 1660                 1665             


Leu Ala  Val Gly Arg Ser Ser  Glu Lys Glu Gly Lys  Asp Ile Pro 
    1670                 1675                 1680             


Pro Asp  Glu Thr Gln Ser Thr  Gln Lys Gln His Lys  Pro Ser Leu 
    1685                 1690                 1695             


Gly Ile  Lys Lys Pro Val Arg  Arg Lys Leu Lys Glu  Lys Gln Lys 
    1700                 1705                 1710             


Gln Lys  Glu Glu Gly Leu Gln  Ala Ser Ala Glu Lys  Ala Glu Leu 
    1715                 1720                 1725             


Lys Lys  Gly Ser Ser Glu Glu  Ser Leu Gly Glu Asp  Pro Gly Leu 
    1730                 1735                 1740             


Ala Pro  Glu Pro Leu Pro Thr  Val Lys Ala Thr Ser  Pro Leu Ile 
    1745                 1750                 1755             


Glu Glu  Thr Pro Ile Gly Ser  Ile Lys Asp Lys Val  Lys Ala Leu 
    1760                 1765                 1770             


Gln Lys  Arg Val Glu Asp Glu  Gln Lys Gly Arg Ser  Lys Leu Pro 
    1775                 1780                 1785             


Ile Arg  Val Lys Gly Lys Glu  Asp Val Pro Lys Lys  Thr Thr His 
    1790                 1795                 1800             


Arg Pro  His Pro Ala Ala Ser  Pro Ser Leu Lys Ser  Glu Arg His 
    1805                 1810                 1815             


Ala Pro  Gly Ser Pro Ser Pro  Lys Thr Glu Arg His  Ser Thr Leu 
    1820                 1825                 1830             


Ser Ser  Ser Ala Lys Thr Glu  Arg His Pro Pro Val  Ser Pro Ser 
    1835                 1840                 1845             


Ser Lys  Thr Glu Lys His Ser  Pro Val Ser Pro Ser  Ala Lys Thr 
    1850                 1855                 1860             


Glu Arg  His Ser Pro Ala Ser  Ser Ser Ser Lys Thr  Glu Lys His 
    1865                 1870                 1875             


Ser Pro  Val Ser Pro Ser Thr  Lys Thr Glu Arg His  Ser Pro Val 
    1880                 1885                 1890             


Ser Ser  Thr Lys Thr Glu Arg  His Pro Pro Val Ser  Pro Ser Gly 
    1895                 1900                 1905             


Lys Thr  Asp Lys Arg Pro Pro  Val Ser Pro Ser Gly  Arg Thr Glu 
    1910                 1915                 1920             


Lys His  Pro Pro Val Ser Pro  Gly Arg Thr Glu Lys  Arg Leu Pro 
    1925                 1930                 1935             


Val Ser  Pro Ser Gly Arg Thr  Asp Lys His Gln Pro  Val Ser Thr 
    1940                 1945                 1950             


Ala Gly  Lys Thr Glu Lys His  Leu Pro Val Ser Pro  Ser Gly Lys 
    1955                 1960                 1965             


Thr Glu  Lys Gln Pro Pro Val  Ser Pro Thr Ser Lys  Thr Glu Arg 
    1970                 1975                 1980             


Ile Glu  Glu Thr Met Ser Val  Arg Glu Leu Met Lys  Ala Phe Gln 
    1985                 1990                 1995             


Ser Gly  Gln Asp Pro Ser Lys  His Lys Thr Gly Leu  Phe Glu His 
    2000                 2005                 2010             


Lys Ser  Ala Lys Gln Lys Gln  Pro Gln Glu Lys Gly  Lys Val Arg 
    2015                 2020                 2025             


Val Glu  Lys Glu Lys Gly Pro  Ile Leu Thr Gln Arg  Glu Ala Gln 
    2030                 2035                 2040             


Lys Thr  Glu Asn Gln Thr Ile  Lys Arg Gly Gln Arg  Leu Pro Val 
    2045                 2050                 2055             


Thr Gly  Thr Ala Glu Ser Lys  Arg Gly Val Arg Val  Ser Ser Ile 
    2060                 2065                 2070             


Gly Val  Lys Lys Glu Asp Ala  Ala Gly Gly Lys Glu  Lys Val Leu 
    2075                 2080                 2085             


Ser His  Lys Ile Pro Glu Pro  Val Gln Ser Val Pro  Glu Glu Glu 
    2090                 2095                 2100             


Ser His  Arg Glu Ser Glu Val  Pro Lys Glu Lys Met  Ala Asp Glu 
    2105                 2110                 2115             


Gln Gly  Asp Met Asp Leu Gln  Ile Ser Pro Asp Arg  Lys Thr Ser 
    2120                 2125                 2130             


Thr Asp  Phe Ser Glu Val Ile  Lys Gln Glu Leu Glu  Asp Asn Asp 
    2135                 2140                 2145             


Lys Tyr  Gln Gln Phe Arg Leu  Ser Glu Glu Thr Glu  Lys Ala Gln 
    2150                 2155                 2160             


Leu His  Leu Asp Gln Val Leu  Thr Ser Pro Phe Asn  Thr Thr Phe 
    2165                 2170                 2175             


Pro Leu  Asp Tyr Met Lys Asp  Glu Phe Leu Pro Ala  Leu Ser Leu 
    2180                 2185                 2190             


Gln Ser  Gly Ala Leu Asp Gly  Ser Ser Glu Ser Leu  Lys Asn Glu 
    2195                 2200                 2205             


Gly Val  Ala Gly Ser Pro Cys  Gly Ser Leu Met Glu  Gly Thr Pro 
    2210                 2215                 2220             


Gln Ile  Ser Ser Glu Glu Ser  Tyr Lys His Glu Gly  Leu Ala Glu 
    2225                 2230                 2235             


Thr Pro  Glu Thr Ser Pro Glu  Ser Leu Ser Phe Ser  Pro Lys Lys 
    2240                 2245                 2250             


Ser Glu  Glu Gln Thr Gly Glu  Thr Lys Glu Ser Thr  Lys Thr Glu 
    2255                 2260                 2265             


Thr Thr  Thr Glu Ile Arg Ser  Glu Lys Glu His Pro  Thr Thr Lys 
    2270                 2275                 2280             


Asp Ile  Thr Gly Gly Ser Glu  Glu Arg Gly Ala Thr  Val Thr Glu 
    2285                 2290                 2295             


Asp Ser  Glu Thr Ser Thr Glu  Ser Phe Gln Lys Glu  Ala Thr Leu 
    2300                 2305                 2310             


Gly Ser  Pro Lys Asp Thr Ser  Pro Lys Arg Gln Asp  Asp Cys Thr 
    2315                 2320                 2325             


Gly Ser  Cys Ser Val Ala Leu  Ala Lys Glu Thr Pro  Thr Gly Leu 
    2330                 2335                 2340             


Thr Glu  Glu Ala Ala Cys Asp  Glu Gly Gln Arg Thr  Phe Gly Ser 
    2345                 2350                 2355             


Ser Ala  His Lys Thr Gln Thr  Asp Ser Glu Val Gln  Glu Ser Thr 
    2360                 2365                 2370             


Ala Thr  Ser Asp Glu Thr Lys  Ala Leu Pro Leu Pro  Glu Ala Ser 
    2375                 2380                 2385             


Val Lys  Thr Asp Thr Gly Thr  Glu Ser Lys Pro Gln  Gly Val Ile 
    2390                 2395                 2400             


Arg Ser  Pro Gln Gly Leu Glu  Leu Ala Leu Pro Ser  Arg Asp Ser 
    2405                 2410                 2415             


Glu Val  Leu Ser Ala Val Ala  Asp Asp Ser Leu Ala  Val Ser His 
    2420                 2425                 2430             


Lys Asp  Ser Leu Glu Ala Ser  Pro Val Leu Glu Asp  Asn Ser Ser 
    2435                 2440                 2445             


His Lys  Thr Pro Asp Ser Leu  Glu Pro Ser Pro Leu  Lys Glu Ser 
    2450                 2455                 2460             


Pro Cys  Arg Asp Ser Leu Glu  Ser Ser Pro Val Glu  Pro Lys Met 
    2465                 2470                 2475             


Lys Ala  Gly Ile Phe Pro Ser  His Phe Pro Leu Pro  Ala Ala Val 
    2480                 2485                 2490             


Ala Lys  Thr Glu Leu Leu Thr  Glu Val Ala Ser Val  Arg Ser Arg 
    2495                 2500                 2505             


Leu Leu  Arg Asp Pro Asp Gly  Ser Ala Glu Asp Asp  Ser Leu Glu 
    2510                 2515                 2520             


Gln Thr  Ser Leu Met Glu Ser  Ser Gly Lys Ser Pro  Leu Ser Pro 
    2525                 2530                 2535             


Asp Thr  Pro Ser Ser Glu Glu  Val Ser Tyr Glu Val  Thr Pro Lys 
    2540                 2545                 2550             


Thr Thr  Asp Val Ser Thr Pro  Lys Pro Ala Val Ile  His Glu Cys 
    2555                 2560                 2565             


Ala Glu  Glu Asp Asp Ser Glu  Asn Gly Glu Lys Lys  Arg Phe Thr 
    2570                 2575                 2580             


Pro Glu  Glu Glu Met Phe Lys  Met Val Thr Lys Ile  Lys Met Phe 
    2585                 2590                 2595             


Asp Glu  Leu Glu Gln Glu Ala  Lys Gln Lys Arg Asp  Tyr Lys Lys 
    2600                 2605                 2610             


Glu Pro  Lys Gln Glu Glu Ser  Ser Ser Ser Ser Asp  Pro Asp Ala 
    2615                 2620                 2625             


Asp Cys  Ser Val Asp Val Asp  Glu Pro Lys His Thr  Gly Ser Gly 
    2630                 2635                 2640             


Glu Asp  Glu Ser Gly Val Pro  Val Leu Val Thr Ser  Glu Ser Arg 
    2645                 2650                 2655             


Lys Val  Ser Ser Ser Ser Glu  Ser Glu Pro Glu Leu  Ala Gln Leu 
    2660                 2665                 2670             


Lys Lys  Gly Ala Asp Ser Gly  Leu Leu Pro Glu Pro  Val Ile Arg 
    2675                 2680                 2685             


Val Gln  Pro Pro Ser Pro Leu  Pro Ser Ser Met Asp  Ser Asn Ser 
    2690                 2695                 2700             


Ser Pro  Glu Glu Val Gln Phe  Gln Pro Val Val Ser  Lys Gln Tyr 
    2705                 2710                 2715             


Thr Phe  Lys Met Asn Glu Asp  Thr Gln Glu Glu Pro  Gly Lys Ser 
    2720                 2725                 2730             


Glu Glu  Glu Lys Asp Ser Glu  Ser His Leu Ala Glu  Asp Arg His 
    2735                 2740                 2745             


Ala Val  Ser Thr Glu Ala Glu  Asp Arg Ser Tyr Asp  Lys Leu Asn 
    2750                 2755                 2760             


Arg Asp  Thr Asp Gln Pro Lys  Ile Cys Asp Gly His  Gly Cys Glu 
    2765                 2770                 2775             


Ala Met  Ser Pro Ser Ser Ser  Ala Ala Pro Val Ser  Ser Gly Leu 
    2780                 2785                 2790             


Gln Ser  Pro Thr Gly Asp Asp  Val Asp Glu Gln Pro  Val Ile Tyr 
    2795                 2800                 2805             


Lys Glu  Ser Leu Ala Leu Gln  Gly Thr His Glu Lys  Asp Thr Glu 
    2810                 2815                 2820             


Gly Glu  Glu Leu Asp Val Ser  Arg Ala Glu Ser Pro  Gln Ala Asp 
    2825                 2830                 2835             


Cys Pro  Ser Glu Ser Phe Ser  Ser Ser Ser Ser Leu  Pro His Cys 
    2840                 2845                 2850             


Leu Val  Ser Glu Gly Lys Glu  Leu Asp Glu Asp Ile  Ser Ala Thr 
    2855                 2860                 2865             


Ser Ser  Ile Gln Lys Thr Glu  Val Thr Lys Thr Asp  Glu Thr Phe 
    2870                 2875                 2880             


Glu Asn  Leu Pro Lys Asp Cys  Pro Ser Gln Asp Ser  Ser Ile Thr 
    2885                 2890                 2895             


Thr Gln  Thr Asp Arg Phe Ser  Met Asp Val Pro Val  Ser Asp Leu 
    2900                 2905                 2910             


Ala Glu  Asn Asp Glu Ile Tyr  Asp Pro Gln Ile Thr  Ser Pro Tyr 
    2915                 2920                 2925             


Glu Asn  Val Pro Ser Gln Ser  Phe Phe Ser Ser Glu  Glu Ser Lys 
    2930                 2935                 2940             


Thr Gln  Thr Asp Ala Asn His  Thr Thr Ser Phe His  Ser Ser Glu 
    2945                 2950                 2955             


Val Tyr  Ser Val Thr Ile Thr  Ser Pro Val Glu Asp  Val Val Val 
    2960                 2965                 2970             


Ala Ser  Ser Ser Ser Gly Thr  Val Leu Ser Lys Glu  Ser Asn Phe 
    2975                 2980                 2985             


Glu Gly  Gln Asp Ile Lys Met  Glu Ser Gln Gln Glu  Ser Thr Leu 
    2990                 2995                 3000             


Trp Glu  Met Gln Ser Asp Ser  Val Ser Ser Ser Phe  Glu Pro Thr 
    3005                 3010                 3015             


Met Ser  Ala Thr Thr Thr Val  Val Gly Glu Gln Ile  Ser Lys Val 
    3020                 3025                 3030             


Ile Ile  Thr Lys Thr Asp Val  Asp Ser Asp Ser Trp  Ser Glu Ile 
    3035                 3040                 3045             


Arg Glu  Asp Asp Glu Ala Phe  Glu Ala Arg Val Lys  Glu Glu Glu 
    3050                 3055                 3060             


Gln Lys  Ile Phe Gly Leu Met  Val Asp Arg Gln Ser  Gln Gly Thr 
    3065                 3070                 3075             


Thr Pro  Asp Thr Thr Pro Ala  Arg Thr Pro Thr Glu  Glu Gly Thr 
    3080                 3085                 3090             


Pro Thr  Ser Glu Gln Asn Pro  Phe Leu Phe Gln Glu  Gly Lys Leu 
    3095                 3100                 3105             


Phe Glu  Met Thr Arg Ser Gly  Ala Ile Asp Met Thr  Lys Arg Ser 
    3110                 3115                 3120             


Tyr Ala  Asp Glu Ser Phe His  Phe Phe Gln Ile Gly  Gln Glu Ser 
    3125                 3130                 3135             


Arg Glu  Glu Thr Leu Ser Glu  Asp Val Lys Glu Gly  Ala Thr Gly 
    3140                 3145                 3150             


Ala Asp  Pro Leu Pro Leu Glu  Thr Ser Ala Glu Ser  Leu Ala Leu 
    3155                 3160                 3165             


Ser Glu  Ser Lys Glu Thr Val  Asp Asp Glu Ala Asp  Leu Leu Pro 
    3170                 3175                 3180             


Asp Asp  Val Ser Glu Glu Val  Glu Glu Ile Pro Ala  Ser Asp Ala 
    3185                 3190                 3195             


Gln Leu  Asn Ser Gln Met Gly  Ile Ser Ala Ser Thr  Glu Thr Pro 
    3200                 3205                 3210             


Thr Lys  Glu Ala Val Ser Val  Gly Thr Lys Asp Leu  Pro Thr Val 
    3215                 3220                 3225             


Gln Thr  Gly Asp Ile Pro Pro  Leu Ser Gly Val Lys  Gln Ile Ser 
    3230                 3235                 3240             


Cys Pro  Asp Ser Ser Glu Pro  Ala Val Gln Val Gln  Leu Asp Phe 
    3245                 3250                 3255             


Ser Thr  Leu Thr Arg Ser Val  Tyr Ser Asp Arg Gly  Asp Asp Ser 
    3260                 3265                 3270             


Pro Asp  Ser Ser Pro Glu Glu  Gln Lys Ser Val Ile  Glu Ile Pro 
    3275                 3280                 3285             


Thr Ala  Pro Met Glu Asn Val  Pro Phe Thr Glu Ser  Lys Ser Lys 
    3290                 3295                 3300             


Ile Pro  Val Arg Thr Met Pro  Thr Ser Thr Pro Ala  Pro Pro Ser 
    3305                 3310                 3315             


Ala Glu  Tyr Glu Ser Ser Val  Ser Glu Asp Phe Leu  Ser Ser Val 
    3320                 3325                 3330             


Asp Glu  Glu Asn Lys Ala Asp  Glu Ala Lys Pro Lys  Ser Lys Leu 
    3335                 3340                 3345             


Pro Val  Lys Val Pro Leu Gln  Arg Val Glu Gln Gln  Leu Ser Asp 
    3350                 3355                 3360             


Leu Asp  Thr Ser Val Gln Lys  Thr Val Ala Pro Gln  Gly Gln Asp 
    3365                 3370                 3375             


Met Ala  Ser Ile Ala Pro Asp  Asn Arg Ser Lys Ser  Glu Ser Asp 
    3380                 3385                 3390             


Ala Ser  Ser Leu Asp Ser Lys  Thr Lys Cys Pro Val  Lys Thr Arg 
    3395                 3400                 3405             


Ser Tyr  Thr Glu Thr Glu Thr  Glu Ser Arg Glu Arg  Ala Glu Glu 
    3410                 3415                 3420             


Leu Glu  Leu Glu Ser Glu Glu  Gly Ala Thr Arg Pro  Lys Ile Leu 
    3425                 3430                 3435             


Thr Ser  Arg Leu Pro Val Lys  Ser Arg Ser Thr Thr  Ser Ser Cys 
    3440                 3445                 3450             


Arg Gly  Gly Thr Ser Pro Thr  Lys Glu Ser Lys Glu  His Phe Phe 
    3455                 3460                 3465             


Asp Leu  Tyr Arg Asn Ser Ile  Glu Phe Phe Glu Glu  Ile Ser Asp 
    3470                 3475                 3480             


Glu Ala  Ser Lys Leu Val Asp  Arg Leu Thr Gln Ser  Glu Arg Glu 
    3485                 3490                 3495             


Gln Glu  Ile Val Ser Asp Asp  Glu Ser Ser Ser Ala  Leu Glu Val 
    3500                 3505                 3510             


Ser Val  Ile Glu Asn Leu Pro  Pro Val Glu Thr Glu  His Ser Val 
    3515                 3520                 3525             


Pro Glu  Asp Ile Phe Asp Thr  Arg Pro Ile Trp Asp  Glu Ser Ile 
    3530                 3535                 3540             


Glu Thr  Leu Ile Glu Arg Ile  Pro Asp Glu Asn Gly  His Asp His 
    3545                 3550                 3555             


Ala Glu  Asp Pro Gln Asp Glu  Gln Glu Arg Ile Glu  Glu Arg Leu 
    3560                 3565                 3570             


Ala Tyr  Ile Ala Asp His Leu  Gly Phe Ser Trp Thr  Glu Leu Ala 
    3575                 3580                 3585             


Arg Glu  Leu Asp Phe Thr Glu  Glu Gln Ile His Gln  Ile Arg Ile 
    3590                 3595                 3600             


Glu Asn  Pro Asn Ser Leu Gln  Asp Gln Ser His Ala  Leu Leu Lys 
    3605                 3610                 3615             


Tyr Trp  Leu Glu Arg Asp Gly  Lys His Ala Thr Asp  Thr Asn Leu 
    3620                 3625                 3630             


Val Glu  Cys Leu Thr Lys Ile  Asn Arg Met Asp Ile  Val His Leu 
    3635                 3640                 3645             


Met Glu  Thr Asn Thr Glu Pro  Leu Gln Glu Arg Ile  Ser His Ser 
    3650                 3655                 3660             


Tyr Ala  Glu Ile Glu Gln Thr  Ile Thr Leu Asp His  Ser Glu Gly 
    3665                 3670                 3675             


Phe Ser  Val Leu Gln Glu Glu  Leu Cys Thr Ala Gln  His Lys Gln 
    3680                 3685                 3690             


Lys Glu  Glu Gln Ala Val Ser  Lys Glu Ser Glu Thr  Cys Asp His 
    3695                 3700                 3705             


Pro Pro  Ile Val Ser Glu Glu  Asp Ile Ser Val Gly  Tyr Ser Thr 
    3710                 3715                 3720             


Phe Gln  Asp Gly Val Pro Lys  Thr Glu Gly Asp Ser  Ser Ala Thr 
    3725                 3730                 3735             


Ala Leu  Phe Pro Gln Thr His  Lys Glu Gln Val Gln  Gln Asp Phe 
    3740                 3745                 3750             


Ser Gly  Lys Met Gln Asp Leu  Pro Glu Glu Ser Ser  Leu Glu Tyr 
    3755                 3760                 3765             


Gln Gln  Glu Tyr Phe Val Thr  Thr Pro Gly Thr Glu  Thr Ser Glu 
    3770                 3775                 3780             


Thr Gln  Lys Ala Met Ile Val  Pro Ser Ser Pro Ser  Lys Thr Pro 
    3785                 3790                 3795             


Glu Glu  Val Ser Thr Pro Ala  Glu Glu Glu Lys Leu  Tyr Leu Gln 
    3800                 3805                 3810             


Thr Pro  Thr Ser Ser Glu Arg  Gly Gly Ser Pro Ile  Ile Gln Glu 
    3815                 3820                 3825             


Pro Glu  Glu Pro Ser Glu His  Arg Glu Glu Ser Ser  Pro Arg Lys 
    3830                 3835                 3840             


Thr Ser  Leu Val Ile Val Glu  Ser Ala Asp Asn Gln  Pro Glu Thr 
    3845                 3850                 3855             


Cys Glu  Arg Leu Asp Glu Asp  Ala Ala Phe Glu Lys  Gly Asp Asp 
    3860                 3865                 3870             


Met Pro  Glu Ile Pro Pro Glu  Thr Val Thr Glu Glu  Glu Tyr Ile 
    3875                 3880                 3885             


Asp Glu  His Gly His Thr Val  Val Lys Lys Val Thr  Arg Lys Ile 
    3890                 3895                 3900             


Ile Arg  Arg Tyr Val Ser Ser  Glu Gly Thr Glu Lys  Glu Glu Ile 
    3905                 3910                 3915             


Met Val  Gln Gly Met Pro Gln  Glu Pro Val Asn Ile  Glu Glu Gly 
    3920                 3925                 3930             


Asp Gly  Tyr Ser Lys Val Ile  Lys Arg Val Val Leu  Lys Ser Asp 
    3935                 3940                 3945             


Thr Glu  Gln Ser Glu Asp Asn  Asn Glu 
    3950                 3955         

<210>  2018
<211>  8085
<212>  DNA
<213>  Homo sapiens

<400>  2018
agatttaaca atgcagtcag ataaacagtt gtggcagctg ctgccatggc aacgtcaccg     60

tccttaccct cccagtgcgc gccccttccc cacccctcct cctcctcctg ctttcctcca    120

gtaagtgcat acccgctagt ggtctgtaca ggcggcacgg tttgatggca gagatatttt    180

ctttccaaac tgttcaaaat gatgaacgaa gatgcagctc agaaaagcga cagtggagag    240

aagttcaacg gcagtagtca gaggagaaaa agacccaaga agtctgacag caatgcaagc    300

ttcctccgtg ctgccagagc aggcaacctg gacaaagttg tggaatatct gaaggggggc    360

atagacatca atacctgcaa tcagaatgga ctcaacgctc tccatctggc tgccaaggaa    420

ggccacgtgg ggctggtgca ggagctgctg ggaagagggt cctctgtgga ttctgccact    480

aagaagggaa ataccgctct tcacattgca tctttggctg gacaagcaga agttgtcaaa    540

gttcttgtta aggaaggagc caatattaat gcacagtctc agaatggctt tactccttta    600

tacatggctg cccaagagaa tcacattgat gttgtaaaat atttgctgga aaatggagct    660

aatcagagca ctgctacaga ggatggcttt actcctctag ctgtggcact ccagcaagga    720

cacaaccagg cggtggccat cctcttggag aatgacacca aagggaaagt gaggctgcca    780

gctctgcata ttgccgctag gaaagacgac accaaatctg ccgcacttct gcttcagaat    840

gaccacaatg ctgacgtaca atccaagatg atggtgaata ggacaactga gagtggtttt    900

acccctttgc acatagctgc acattacgga aatgtcaacg tggcaactct tcttctaaac    960

cggggagctg ctgtggactt cacagccagg aatggaatca ctcctctgca tgtggcttcc   1020

aaaagaggaa atacaaacat ggtgaagctc ttactggatc gaggcggtca gatcgatgcc   1080

aaaactaggg atgggttgac accacttcac tgtgctgcac gaagtgggca tgaccaagtg   1140

gtggaacttc tgttggaacg gggtgccccc ttgctggcaa ggactaagaa tgggctgtct   1200

ccactacaca tggctgccca gggagaccac gtggaatgtg tgaagcacct gttacagcac   1260

aaggcacctg ttgatgatgt caccctagac tacctgacag ccctccacgt tgctgcgcac   1320

tgtggccact accgtgtaac caaactcctt ttagacaaga gagccaatcc gaacgccaga   1380

gccctgaatg gttttactcc actgcacatt gcctgcaaga aaaaccgcat caaagtcatg   1440

gaactgctgg tgaaatatgg ggcttcaatc caagctataa cagagtctgg cctcacacca   1500

atacatgtgg ctgccttcat gggccacttg aacattgtcc tccttctgct gcagaacgga   1560

gcctctccag atgtcactaa cattcgtggt gagacggcac tacacatggc agcccgagcc   1620

gggcaggtgg aagtggtccg atgcctcctg agaaatggtg cccttgttga tgccagagcc   1680

agggaggaac agacaccttt acatattgcc tcccgcctgg gtaagacaga aattgtccag   1740

ctgcttctac aacatatggc tcatccagat gcggccacta caaatgggta cacaccactg   1800

cacatctctg cccgggaggg ccaggtggat gtggcatcag tcctattgga agcaggagca   1860

gcccactcct tagctaccaa gaagggtttt actcccctgc atgtagcagc caagtatgga   1920

agcctggatg tggcaaaact tctcttgcaa cgccgtgctg ccgcagattc tgcagggaag   1980

aacggcctta ccccgctcca tgttgctgct cattatgaca accagaaggt ggcgctgctg   2040

ttactggaga agggtgcttc ccctcatgcc actgccaaga atggctatac tccgttacat   2100

attgctgcca agaagaatca aatgcagata gcttccacac tcctgaacta tggagcagag   2160

acaaacattg tgacaaagca aggagtaact ccactccatc tggcctcgca ggaggggcac   2220

acagatatgg ttaccttgct tctggataag ggagccaata tccacatgtc aactaagagt   2280

ggactcacat ccttacacct tgcagcccag gaagataaag tgaatgttgc tgatattctc   2340

accaagcatg gagctgatca ggatgctcat acaaagcttg gttacacacc tttaattgtg   2400

gcctgtcact atggaaatgt gaaaatggtc aactttcttc tgaagcaggg agcaaatgtt   2460

aacgcaaaaa ccaagaacgg ctacacgcct ttgcaccagg ccgctcagca gggtcacacg   2520

cacatcatca acgtcctgct ccagcatggg gccaagccca acgccaccac tgcgaatggc   2580

aacactgcct tggcgattgc taagcgtctg ggctacatct ccgtggtcga caccctgaag   2640

gttgtgactg aggaggtcac caccaccacc acaactatta cagaaaaaca caaactaaat   2700

gtacctgaga cgatgactga ggttcttgat gtttctgatg aagagggtga tgacacaatg   2760

actggtgatg ggggagaata ccttaggcct gaggacctaa aagaactggg tgatgactca   2820

ctacccagca gtcagttcct ggatggtatg aattacctgc gatacagctt ggagggagga   2880

cgatctgaca gccttcgatc cttcagttcc gacaggtctc acactctgag ccatgcctcc   2940

tacctgaggg acagtgccgt gatggatgac tcagttgtga ttcccagtca ccaggtgtca   3000

actctagcca aggaggcaga aaggaattct tatcgcctaa gctggggcac tgagaactta   3060

gacaacgtgg ctctttcttc tagtcctatt cattcaggtt tcctggttag ttttatggtg   3120

gatgcccgag gtggtgctat gcgaggatgc agacacaatg ggctccgaat cattattcca   3180

cctcggaaat gtactgctcc aacgcgagtc acctgccgac tggtcaagcg ccacagactg   3240

gcaacaatgc ctccaatggt ggaaggagaa ggcctggcca gtcgcctgat cgaagttgga   3300

ccttctggtg ctcagttcct tggtaaactt cacctgccaa cggctcctcc cccacttaat   3360

gagggagaaa gtttggtcag ccgcattctt cagctggggc ctcctggaac caaattcctt   3420

gggcctgtga tcgtggagat ccctcacttt gcggcccttc gaggaaagga aagggaactg   3480

gtggtcctgc gcagtgagaa tggggacagc tggaaagagc atttctgtga ctacactgaa   3540

gatgaattga atgaaattct taacggcatg gatgaagtac tggatagccc agaagaccta   3600

gaaaagaaac gaatctgccg catcatcacc cgagacttcc cacagtactt tgcagtggtg   3660

tctcgtatca aacaggacag caatctgatt ggcccagaag gaggtgtact gagcagcaca   3720

gtggtgcccc aggtgcaggc cgtcttccca gagggggcac tcaccaagcg gatccgcgta   3780

ggcctgcagg ctcaacctat gcacagtgag ctggttaaga agatcctagg caacaaagct   3840

accttcagcc ctatagtcac tttggaacct agaagaagaa aattccacaa accaattacc   3900

atgaccattc ctgtccccaa agcttcaagt gatgtcatgt tgaatggttt tgggggagat   3960

gcaccaacct taagattact atgcagcata acaggtggaa ccacccctgc ccagtgggaa   4020

gatattacag gaactacgcc attaacattt gtcaatgaat gtgtttcctt tacaacaaac   4080

gtgtctgcca ggttctggct gatagattgt cgacagatcc aggaatccgt tacttttgca   4140

tcacaagtat acagagaaat tatctgcgta ccttatatgg ccaaatttgt agtgtttgcc   4200

aaatcacatg accccattga agccaggttg aggtgtttct gcatgactga tgataaagtg   4260

gataagaccc ttgaacaaca agaaaatttt gctgaggtgg ccagaagcag ggatgtggag   4320

gtgttagaag gaaaacccat ctacgttgat tgtttcggca acttggtacc attaactaaa   4380

agtggccagc atcatatatt cagttttttt gccttcaaag aaaatagact tcctctattt   4440

gtcaaggtac gcgatacgac tcaggaacct tgcggacgac tatcatttat gaaggagcca   4500

aaatccacga gaggcctggt gcatcaagct atttgcaact taaacatcac tttgccgatt   4560

tatacaaagg aatcagagtc agatcaagaa caggaggaag agatcgatat gacatcagaa   4620

aaaaatccac aggatgagca ggaacggatc gaggaaaggc tggcttatat tgctgatcac   4680

cttggcttca gctggacaga attagcaaga gaactggatt tcactgagga gcaaattcat   4740

caaattcgaa ttgaaaatcc caactctctt caagaccaga gtcatgcact gttgaagtac   4800

tggctagaga gggatgggaa acatgctaca gataccaacc tcgttgaatg tctcaccaag   4860

atcaaccgaa tggatattgt tcatctcatg gagaccaaca cagaacctct ccaggagcgc   4920

atcagtcata gttatgcaga aattgaacag accattacac tggatcatag tgaagggttc   4980

tcggtacttc aagaggagtt atgcactgca cagcacaagc agaaagagga gcaagctgtt   5040

tctaaagaaa gtgagacctg cgatcaccct cctatcgtct cagaggaaga catttctgtt   5100

ggttattcca cttttcagga tggcgtcccc aaaactgagg gggacagctc agcaacagca   5160

ctctttcccc aaactcacaa ggagcaagtt caacaggatt tctcagggaa aatgcaagac   5220

ctgcctgaag agtcatctct ggaatatcag caggaatatt ttgtgacaac tccaggaaca   5280

gaaacatcag agactcagaa ggctatgata gtacccagct ctcccagcaa gacacctgag   5340

gaagttagca cccctgcaga ggaggagaag ctgtacctcc agaccccaac atccagcgag   5400

cggggaggct ctcccatcat acaagaaccc gaagagccct cagagcacag agaggagagc   5460

tctccgcgga aaaccagcct cgtaatagtg gagtctgccg ataaccagcc tgagacctgt   5520

gaaagactcg atgaagatgc agcttttgaa aagggagacg atatgcctga aataccccca   5580

gaaacagtca cagaagaaga atacattgat gagcatggac acaccgtggt aaagaaggtt   5640

actaggaaaa tcattaggcg gtatgtatcc tctgaaggca cagagaaaga agagattatg   5700

gtgcagggaa tgccacagga acctgtcaac atcgaggaag gggatggcta ttccaaagtt   5760

ataaagcgtg ttgtattgaa gagtgacacc gagcagtcag aggacaacaa tgagtaaagc   5820

catcacacag aagagggctg tggtgaagga ccagcatgga aaacgcattg acttggagca   5880

cctggaggat gtaccagaag cactagacca ggacgacctc cagcgcgatc tccagcagct   5940

ccttcggcat ttctgcaagg aggacttgaa gcaagaggcc aagtgagggg ctgcccagtt   6000

ctcacaccag aaaccacaca ttcactcaat atgcagcttc ctgtttcagt aggggagtga   6060

cctaactggc ctaattaatg ggataccccg acatttccac tgttagcaaa tatacggcat   6120

tttgctttag ttttccccca tcctctttaa ctataaagct aatttgtgac caaagatggc   6180

atccttcata ctggatgctg tatccaatac tttgttgtgt ctgtgctaac ctgggaactg   6240

gccacctcca ttgttctttg cttctgcaca agatccatga aaatccattg atcagaagaa   6300

cttcacctgc agacctcttc aagtgacact atgtaggaat ccttccaagg aatatctatg   6360

tacaatgtat atagctgaaa tgctcagatg aacaacatat taaaattaaa accactgcct   6420

attgtaacta cactgggcat cagaataaaa ggcctctaga aattgctgaa caatggttaa   6480

ttaagatatt gctaacacaa tcgagtgata atacagtttt actgcaaaag aagcacttca   6540

aacctattat gtccttagaa cttccagagt agccactgct cccagttaaa ggtgggtcag   6600

tagccttgca gaactgtcct gagaagttat tgctggtgct ggccagccat ggcttaggac   6660

tccaacagcc actctgaggg aggggagaag ggagcagagg ccacgcagaa tgaaccgatg   6720

gggtattcag ttgctggcag ctacattgtg tggcattcta gcatcttcag gtctttagat   6780

cttggacaag ttggcagggt attttaaaag ctataactac tgtagttttc cagttttcat   6840

tgctgcttta gcaaaccacg ctgtcttaca gtggtacttt cttctggcca ctgcactgta   6900

gataattcat tggaaacaag atttacccac tacataaaag gttaaactcc ttcagtatgt   6960

tggagtggtt tctttttttt tttctttctt tctttttttt cttcaggttt atatcttctc   7020

taatacctgc atgtggcgtt taaaaatcaa gaccacggtc aaacccctct tctaatcaca   7080

ttaattgttt ccattctttt taccctgagt gagcactttt cactttccag ctaggtctgt   7140

ttttcagctt gcagacaaga ttgagaaatc cttgaaaatt tggttttggt taaaattttt   7200

ggtttattta tttgaaatcc acactccctt ggaaactctt aagtgcattt gtgcacttct   7260

gtttgtttgt ctcaaagaag ggactgtaac aatctgagta atttccatgt cctcttcctt   7320

attcctctag tggttgaagc tgtgtagcat tttaacatat atatattcac aaatatattc   7380

atataaacag tatacatttt gaatcagtca tttgttaaag aaaagtatat tcaatgaaga   7440

tgaaatttaa ataaaaaagg acagagtcta tcctccaggg attgaacatt ttccaattat   7500

ctggtctttt cctgttgtgc aaaaatgact cattgctccg aatgtcaaaa acaaatgcga   7560

caaacaatgg cacttcatca tttaaagtaa tgttgccaag agaaaaaatt tcctgggagg   7620

gaggtttccc acaagccaaa tctcctaagc ctcaaatgct agcacttttt ggcagttgga   7680

taggaaatga gacattcttt ggcagccaaa ataagagagg ccgatggtga aactttttga   7740

gacaccctat ggccttcttg tcaaaacctt cactggagct caagaaaagc atttctgttg   7800

tgttatttgc agtgcagatg atgtctgtgt aacaacataa tggttattca cctttttttg   7860

attttgattt ttgctgtgtt atcaaaaact tgaatactgt gagaagaagt gaattttcag   7920

ttgacgaatc agcatcttgt tcccatggtg ataacactaa ttgaatatat ctatgagggc   7980

atgtattagt taatggaaaa aaaaatacaa cactaacaat acatagctgc aatgtgtaca   8040

atggctgatt taattaaata aaatgtacaa gtgttaaatg tggca                   8085


<210>  2019
<211>  1872
<212>  PRT
<213>  Homo sapiens

<400>  2019


Met Met Asn Glu Asp Ala Ala Gln Lys Ser Asp Ser Gly Glu Lys Phe 
1               5                   10                  15      


Asn Gly Ser Ser Gln Arg Arg Lys Arg Pro Lys Lys Ser Asp Ser Asn 
            20                  25                  30          


Ala Ser Phe Leu Arg Ala Ala Arg Ala Gly Asn Leu Asp Lys Val Val 
        35                  40                  45              


Glu Tyr Leu Lys Gly Gly Ile Asp Ile Asn Thr Cys Asn Gln Asn Gly 
    50                  55                  60                  


Leu Asn Ala Leu His Leu Ala Ala Lys Glu Gly His Val Gly Leu Val 
65                  70                  75                  80  


Gln Glu Leu Leu Gly Arg Gly Ser Ser Val Asp Ser Ala Thr Lys Lys 
                85                  90                  95      


Gly Asn Thr Ala Leu His Ile Ala Ser Leu Ala Gly Gln Ala Glu Val 
            100                 105                 110         


Val Lys Val Leu Val Lys Glu Gly Ala Asn Ile Asn Ala Gln Ser Gln 
        115                 120                 125             


Asn Gly Phe Thr Pro Leu Tyr Met Ala Ala Gln Glu Asn His Ile Asp 
    130                 135                 140                 


Val Val Lys Tyr Leu Leu Glu Asn Gly Ala Asn Gln Ser Thr Ala Thr 
145                 150                 155                 160 


Glu Asp Gly Phe Thr Pro Leu Ala Val Ala Leu Gln Gln Gly His Asn 
                165                 170                 175     


Gln Ala Val Ala Ile Leu Leu Glu Asn Asp Thr Lys Gly Lys Val Arg 
            180                 185                 190         


Leu Pro Ala Leu His Ile Ala Ala Arg Lys Asp Asp Thr Lys Ser Ala 
        195                 200                 205             


Ala Leu Leu Leu Gln Asn Asp His Asn Ala Asp Val Gln Ser Lys Met 
    210                 215                 220                 


Met Val Asn Arg Thr Thr Glu Ser Gly Phe Thr Pro Leu His Ile Ala 
225                 230                 235                 240 


Ala His Tyr Gly Asn Val Asn Val Ala Thr Leu Leu Leu Asn Arg Gly 
                245                 250                 255     


Ala Ala Val Asp Phe Thr Ala Arg Asn Gly Ile Thr Pro Leu His Val 
            260                 265                 270         


Ala Ser Lys Arg Gly Asn Thr Asn Met Val Lys Leu Leu Leu Asp Arg 
        275                 280                 285             


Gly Gly Gln Ile Asp Ala Lys Thr Arg Asp Gly Leu Thr Pro Leu His 
    290                 295                 300                 


Cys Ala Ala Arg Ser Gly His Asp Gln Val Val Glu Leu Leu Leu Glu 
305                 310                 315                 320 


Arg Gly Ala Pro Leu Leu Ala Arg Thr Lys Asn Gly Leu Ser Pro Leu 
                325                 330                 335     


His Met Ala Ala Gln Gly Asp His Val Glu Cys Val Lys His Leu Leu 
            340                 345                 350         


Gln His Lys Ala Pro Val Asp Asp Val Thr Leu Asp Tyr Leu Thr Ala 
        355                 360                 365             


Leu His Val Ala Ala His Cys Gly His Tyr Arg Val Thr Lys Leu Leu 
    370                 375                 380                 


Leu Asp Lys Arg Ala Asn Pro Asn Ala Arg Ala Leu Asn Gly Phe Thr 
385                 390                 395                 400 


Pro Leu His Ile Ala Cys Lys Lys Asn Arg Ile Lys Val Met Glu Leu 
                405                 410                 415     


Leu Val Lys Tyr Gly Ala Ser Ile Gln Ala Ile Thr Glu Ser Gly Leu 
            420                 425                 430         


Thr Pro Ile His Val Ala Ala Phe Met Gly His Leu Asn Ile Val Leu 
        435                 440                 445             


Leu Leu Leu Gln Asn Gly Ala Ser Pro Asp Val Thr Asn Ile Arg Gly 
    450                 455                 460                 


Glu Thr Ala Leu His Met Ala Ala Arg Ala Gly Gln Val Glu Val Val 
465                 470                 475                 480 


Arg Cys Leu Leu Arg Asn Gly Ala Leu Val Asp Ala Arg Ala Arg Glu 
                485                 490                 495     


Glu Gln Thr Pro Leu His Ile Ala Ser Arg Leu Gly Lys Thr Glu Ile 
            500                 505                 510         


Val Gln Leu Leu Leu Gln His Met Ala His Pro Asp Ala Ala Thr Thr 
        515                 520                 525             


Asn Gly Tyr Thr Pro Leu His Ile Ser Ala Arg Glu Gly Gln Val Asp 
    530                 535                 540                 


Val Ala Ser Val Leu Leu Glu Ala Gly Ala Ala His Ser Leu Ala Thr 
545                 550                 555                 560 


Lys Lys Gly Phe Thr Pro Leu His Val Ala Ala Lys Tyr Gly Ser Leu 
                565                 570                 575     


Asp Val Ala Lys Leu Leu Leu Gln Arg Arg Ala Ala Ala Asp Ser Ala 
            580                 585                 590         


Gly Lys Asn Gly Leu Thr Pro Leu His Val Ala Ala His Tyr Asp Asn 
        595                 600                 605             


Gln Lys Val Ala Leu Leu Leu Leu Glu Lys Gly Ala Ser Pro His Ala 
    610                 615                 620                 


Thr Ala Lys Asn Gly Tyr Thr Pro Leu His Ile Ala Ala Lys Lys Asn 
625                 630                 635                 640 


Gln Met Gln Ile Ala Ser Thr Leu Leu Asn Tyr Gly Ala Glu Thr Asn 
                645                 650                 655     


Ile Val Thr Lys Gln Gly Val Thr Pro Leu His Leu Ala Ser Gln Glu 
            660                 665                 670         


Gly His Thr Asp Met Val Thr Leu Leu Leu Asp Lys Gly Ala Asn Ile 
        675                 680                 685             


His Met Ser Thr Lys Ser Gly Leu Thr Ser Leu His Leu Ala Ala Gln 
    690                 695                 700                 


Glu Asp Lys Val Asn Val Ala Asp Ile Leu Thr Lys His Gly Ala Asp 
705                 710                 715                 720 


Gln Asp Ala His Thr Lys Leu Gly Tyr Thr Pro Leu Ile Val Ala Cys 
                725                 730                 735     


His Tyr Gly Asn Val Lys Met Val Asn Phe Leu Leu Lys Gln Gly Ala 
            740                 745                 750         


Asn Val Asn Ala Lys Thr Lys Asn Gly Tyr Thr Pro Leu His Gln Ala 
        755                 760                 765             


Ala Gln Gln Gly His Thr His Ile Ile Asn Val Leu Leu Gln His Gly 
    770                 775                 780                 


Ala Lys Pro Asn Ala Thr Thr Ala Asn Gly Asn Thr Ala Leu Ala Ile 
785                 790                 795                 800 


Ala Lys Arg Leu Gly Tyr Ile Ser Val Val Asp Thr Leu Lys Val Val 
                805                 810                 815     


Thr Glu Glu Val Thr Thr Thr Thr Thr Thr Ile Thr Glu Lys His Lys 
            820                 825                 830         


Leu Asn Val Pro Glu Thr Met Thr Glu Val Leu Asp Val Ser Asp Glu 
        835                 840                 845             


Glu Gly Asp Asp Thr Met Thr Gly Asp Gly Gly Glu Tyr Leu Arg Pro 
    850                 855                 860                 


Glu Asp Leu Lys Glu Leu Gly Asp Asp Ser Leu Pro Ser Ser Gln Phe 
865                 870                 875                 880 


Leu Asp Gly Met Asn Tyr Leu Arg Tyr Ser Leu Glu Gly Gly Arg Ser 
                885                 890                 895     


Asp Ser Leu Arg Ser Phe Ser Ser Asp Arg Ser His Thr Leu Ser His 
            900                 905                 910         


Ala Ser Tyr Leu Arg Asp Ser Ala Val Met Asp Asp Ser Val Val Ile 
        915                 920                 925             


Pro Ser His Gln Val Ser Thr Leu Ala Lys Glu Ala Glu Arg Asn Ser 
    930                 935                 940                 


Tyr Arg Leu Ser Trp Gly Thr Glu Asn Leu Asp Asn Val Ala Leu Ser 
945                 950                 955                 960 


Ser Ser Pro Ile His Ser Gly Phe Leu Val Ser Phe Met Val Asp Ala 
                965                 970                 975     


Arg Gly Gly Ala Met Arg Gly Cys Arg His Asn Gly Leu Arg Ile Ile 
            980                 985                 990         


Ile Pro Pro Arg Lys Cys Thr Ala  Pro Thr Arg Val Thr  Cys Arg Leu 
        995                 1000                 1005             


Val Lys  Arg His Arg Leu Ala  Thr Met Pro Pro Met  Val Glu Gly 
    1010                 1015                 1020             


Glu Gly  Leu Ala Ser Arg Leu  Ile Glu Val Gly Pro  Ser Gly Ala 
    1025                 1030                 1035             


Gln Phe  Leu Gly Lys Leu His  Leu Pro Thr Ala Pro  Pro Pro Leu 
    1040                 1045                 1050             


Asn Glu  Gly Glu Ser Leu Val  Ser Arg Ile Leu Gln  Leu Gly Pro 
    1055                 1060                 1065             


Pro Gly  Thr Lys Phe Leu Gly  Pro Val Ile Val Glu  Ile Pro His 
    1070                 1075                 1080             


Phe Ala  Ala Leu Arg Gly Lys  Glu Arg Glu Leu Val  Val Leu Arg 
    1085                 1090                 1095             


Ser Glu  Asn Gly Asp Ser Trp  Lys Glu His Phe Cys  Asp Tyr Thr 
    1100                 1105                 1110             


Glu Asp  Glu Leu Asn Glu Ile  Leu Asn Gly Met Asp  Glu Val Leu 
    1115                 1120                 1125             


Asp Ser  Pro Glu Asp Leu Glu  Lys Lys Arg Ile Cys  Arg Ile Ile 
    1130                 1135                 1140             


Thr Arg  Asp Phe Pro Gln Tyr  Phe Ala Val Val Ser  Arg Ile Lys 
    1145                 1150                 1155             


Gln Asp  Ser Asn Leu Ile Gly  Pro Glu Gly Gly Val  Leu Ser Ser 
    1160                 1165                 1170             


Thr Val  Val Pro Gln Val Gln  Ala Val Phe Pro Glu  Gly Ala Leu 
    1175                 1180                 1185             


Thr Lys  Arg Ile Arg Val Gly  Leu Gln Ala Gln Pro  Met His Ser 
    1190                 1195                 1200             


Glu Leu  Val Lys Lys Ile Leu  Gly Asn Lys Ala Thr  Phe Ser Pro 
    1205                 1210                 1215             


Ile Val  Thr Leu Glu Pro Arg  Arg Arg Lys Phe His  Lys Pro Ile 
    1220                 1225                 1230             


Thr Met  Thr Ile Pro Val Pro  Lys Ala Ser Ser Asp  Val Met Leu 
    1235                 1240                 1245             


Asn Gly  Phe Gly Gly Asp Ala  Pro Thr Leu Arg Leu  Leu Cys Ser 
    1250                 1255                 1260             


Ile Thr  Gly Gly Thr Thr Pro  Ala Gln Trp Glu Asp  Ile Thr Gly 
    1265                 1270                 1275             


Thr Thr  Pro Leu Thr Phe Val  Asn Glu Cys Val Ser  Phe Thr Thr 
    1280                 1285                 1290             


Asn Val  Ser Ala Arg Phe Trp  Leu Ile Asp Cys Arg  Gln Ile Gln 
    1295                 1300                 1305             


Glu Ser  Val Thr Phe Ala Ser  Gln Val Tyr Arg Glu  Ile Ile Cys 
    1310                 1315                 1320             


Val Pro  Tyr Met Ala Lys Phe  Val Val Phe Ala Lys  Ser His Asp 
    1325                 1330                 1335             


Pro Ile  Glu Ala Arg Leu Arg  Cys Phe Cys Met Thr  Asp Asp Lys 
    1340                 1345                 1350             


Val Asp  Lys Thr Leu Glu Gln  Gln Glu Asn Phe Ala  Glu Val Ala 
    1355                 1360                 1365             


Arg Ser  Arg Asp Val Glu Val  Leu Glu Gly Lys Pro  Ile Tyr Val 
    1370                 1375                 1380             


Asp Cys  Phe Gly Asn Leu Val  Pro Leu Thr Lys Ser  Gly Gln His 
    1385                 1390                 1395             


His Ile  Phe Ser Phe Phe Ala  Phe Lys Glu Asn Arg  Leu Pro Leu 
    1400                 1405                 1410             


Phe Val  Lys Val Arg Asp Thr  Thr Gln Glu Pro Cys  Gly Arg Leu 
    1415                 1420                 1425             


Ser Phe  Met Lys Glu Pro Lys  Ser Thr Arg Gly Leu  Val His Gln 
    1430                 1435                 1440             


Ala Ile  Cys Asn Leu Asn Ile  Thr Leu Pro Ile Tyr  Thr Lys Glu 
    1445                 1450                 1455             


Ser Glu  Ser Asp Gln Glu Gln  Glu Glu Glu Ile Asp  Met Thr Ser 
    1460                 1465                 1470             


Glu Lys  Asn Pro Gln Asp Glu  Gln Glu Arg Ile Glu  Glu Arg Leu 
    1475                 1480                 1485             


Ala Tyr  Ile Ala Asp His Leu  Gly Phe Ser Trp Thr  Glu Leu Ala 
    1490                 1495                 1500             


Arg Glu  Leu Asp Phe Thr Glu  Glu Gln Ile His Gln  Ile Arg Ile 
    1505                 1510                 1515             


Glu Asn  Pro Asn Ser Leu Gln  Asp Gln Ser His Ala  Leu Leu Lys 
    1520                 1525                 1530             


Tyr Trp  Leu Glu Arg Asp Gly  Lys His Ala Thr Asp  Thr Asn Leu 
    1535                 1540                 1545             


Val Glu  Cys Leu Thr Lys Ile  Asn Arg Met Asp Ile  Val His Leu 
    1550                 1555                 1560             


Met Glu  Thr Asn Thr Glu Pro  Leu Gln Glu Arg Ile  Ser His Ser 
    1565                 1570                 1575             


Tyr Ala  Glu Ile Glu Gln Thr  Ile Thr Leu Asp His  Ser Glu Gly 
    1580                 1585                 1590             


Phe Ser  Val Leu Gln Glu Glu  Leu Cys Thr Ala Gln  His Lys Gln 
    1595                 1600                 1605             


Lys Glu  Glu Gln Ala Val Ser  Lys Glu Ser Glu Thr  Cys Asp His 
    1610                 1615                 1620             


Pro Pro  Ile Val Ser Glu Glu  Asp Ile Ser Val Gly  Tyr Ser Thr 
    1625                 1630                 1635             


Phe Gln  Asp Gly Val Pro Lys  Thr Glu Gly Asp Ser  Ser Ala Thr 
    1640                 1645                 1650             


Ala Leu  Phe Pro Gln Thr His  Lys Glu Gln Val Gln  Gln Asp Phe 
    1655                 1660                 1665             


Ser Gly  Lys Met Gln Asp Leu  Pro Glu Glu Ser Ser  Leu Glu Tyr 
    1670                 1675                 1680             


Gln Gln  Glu Tyr Phe Val Thr  Thr Pro Gly Thr Glu  Thr Ser Glu 
    1685                 1690                 1695             


Thr Gln  Lys Ala Met Ile Val  Pro Ser Ser Pro Ser  Lys Thr Pro 
    1700                 1705                 1710             


Glu Glu  Val Ser Thr Pro Ala  Glu Glu Glu Lys Leu  Tyr Leu Gln 
    1715                 1720                 1725             


Thr Pro  Thr Ser Ser Glu Arg  Gly Gly Ser Pro Ile  Ile Gln Glu 
    1730                 1735                 1740             


Pro Glu  Glu Pro Ser Glu His  Arg Glu Glu Ser Ser  Pro Arg Lys 
    1745                 1750                 1755             


Thr Ser  Leu Val Ile Val Glu  Ser Ala Asp Asn Gln  Pro Glu Thr 
    1760                 1765                 1770             


Cys Glu  Arg Leu Asp Glu Asp  Ala Ala Phe Glu Lys  Gly Asp Asp 
    1775                 1780                 1785             


Met Pro  Glu Ile Pro Pro Glu  Thr Val Thr Glu Glu  Glu Tyr Ile 
    1790                 1795                 1800             


Asp Glu  His Gly His Thr Val  Val Lys Lys Val Thr  Arg Lys Ile 
    1805                 1810                 1815             


Ile Arg  Arg Tyr Val Ser Ser  Glu Gly Thr Glu Lys  Glu Glu Ile 
    1820                 1825                 1830             


Met Val  Gln Gly Met Pro Gln  Glu Pro Val Asn Ile  Glu Glu Gly 
    1835                 1840                 1845             


Asp Gly  Tyr Ser Lys Val Ile  Lys Arg Val Val Leu  Lys Ser Asp 
    1850                 1855                 1860             


Thr Glu  Gln Ser Glu Asp Asn  Asn Glu 
    1865                 1870         

<210>  2020
<211>  1001
<212>  DNA
<213>  Homo sapiens

<400>  2020
agaggtggcc tcttcctggc tccagtcaga agacacagtc tgtctggagg agtccccaaa     60

gactgttcca attggtgatg tgtgtctaag gatggctttt tcaactagta ggatgcttct    120

ctgcacttgc agccacccaa ctgctgaaga gctggaagtc tagtgctccg ccttcccccg    180

ggaccatttc tgagtgtggg tgcacaccta tgcctgtgtg cgtgcaggtg tgtgctgctg    240

gaggtctcgg tttgggacct tagttcattg tagtgagttg tgggtgctgc agaggctgga    300

gcaagattat gacctagctc gggggcggag tggattatct tgtgagtgtt ctggctgcca    360

gccattgccc tggtggggaa aatcacatct ccatagagct ctgaaatcac ctggattgct    420

ggggagtgga aactgatcct ctgctactgc ttctgctgat ttcctctgca aaatggctca    480

cgctgctgct tctattaaaa aagttcgaga ggctgatctg gatgaaaagg aaaaaaatct    540

tgagagagac agaaaaaaac aacggaaaat ccccagagaa cgtatggaac gaaaaagaaa    600

gtctgacagc aatgcaagct tcctccgtgc tgccagagca ggcaacctgg acaaagttgt    660

ggaatatctg aaggggggca tagacatcaa tacctgcaat cagaatggac tcaacgctct    720

ccatctggct gccaaggaag gccacgtggg gctggtgcag gagctgctgg gaagagggtc    780

ctctgtggat tctgccacta agaagggaaa taccgctctt cacattgcat ctttggctgg    840

acaagcagaa gttgtcaaag ttcttgttaa ggaaggagcc aatattaatg cacagtctca    900

gaatggcttt actcctttat acatggctgc ccaagagaat cacattgatg ttgtaaaata    960

tttgctggaa aatggagcta atcagagcac tgctacagag g                       1001


<210>  2021
<211>  175
<212>  PRT
<213>  Homo sapiens

<400>  2021


Met Ala His Ala Ala Ala Ser Ile Lys Lys Val Arg Glu Ala Asp Leu 
1               5                   10                  15      


Asp Glu Lys Glu Lys Asn Leu Glu Arg Asp Arg Lys Lys Gln Arg Lys 
            20                  25                  30          


Ile Pro Arg Glu Arg Met Glu Arg Lys Arg Lys Ser Asp Ser Asn Ala 
        35                  40                  45              


Ser Phe Leu Arg Ala Ala Arg Ala Gly Asn Leu Asp Lys Val Val Glu 
    50                  55                  60                  


Tyr Leu Lys Gly Gly Ile Asp Ile Asn Thr Cys Asn Gln Asn Gly Leu 
65                  70                  75                  80  


Asn Ala Leu His Leu Ala Ala Lys Glu Gly His Val Gly Leu Val Gln 
                85                  90                  95      


Glu Leu Leu Gly Arg Gly Ser Ser Val Asp Ser Ala Thr Lys Lys Gly 
            100                 105                 110         


Asn Thr Ala Leu His Ile Ala Ser Leu Ala Gly Gln Ala Glu Val Val 
        115                 120                 125             


Lys Val Leu Val Lys Glu Gly Ala Asn Ile Asn Ala Gln Ser Gln Asn 
    130                 135                 140                 


Gly Phe Thr Pro Leu Tyr Met Ala Ala Gln Glu Asn His Ile Asp Val 
145                 150                 155                 160 


Val Lys Tyr Leu Leu Glu Asn Gly Ala Asn Gln Ser Thr Ala Thr 
                165                 170                 175 

<210>  2022
<211>  1353
<212>  DNA
<213>  Homo sapiens

<400>  2022
agtctgtctg gaggagtccc caaagactgt tccaattggt gatgtgtgtc taaggatggc     60

tttttcaact agtaggatgc ttctctgcac ttgcagccac ccaactgctg aagagctgga    120

agtctagtgc tccgccttcc cccgggacca tttctgagtg tgggtgcaca cctatgcctg    180

tgtgcgtgca ggtgtgtgct gctggaggtc tcggtttggg accttagttc attgtagtga    240

gttgtgggtg ctgcagaggc tggagcaaga ttatgaccta gctcgggggc ggagtggatt    300

atcttgtgag tgttctggct gccacctcca ctgaaacacc tacaaaagaa gctgttagtg    360

tagggaccaa ggacctcccc accgtgcaaa cgggtgatat acctcctctc tctggtgtaa    420

agcagatatc ctgccccgac tcttctgaac cagctgtaca agtccagtta gatttttcca    480

cactcaccag gtctgtttat tcagataggg gtgatgattc tcccgattct tccccagaag    540

aacagaaatc agtaatcgag attcctactg cacccatgga gaatgtgcct tttactgaaa    600

gcaaatccaa aattcctgta aggactatgc ccacttccac cccagcacct ccatctgcag    660

agtatgagag ttcagtttct gaagattttc tatccagtgt agatgaggaa aataaggcgg    720

atgaagcaaa accaaagtcc aaactccctg tcaaagtacc cctccaaaga gttgaacagc    780

agctctcaga tctagacacc tctgtccaga agacagtggc tcctcaggga caggacatgg    840

caagcatcgc accagataat agaagcaaat ctgaatctga tgctagttct ttggattcaa    900

agaccaaatg cccagtaaaa acccgaagtt acactgagac agaaacagag agcagagaga    960

gggccgagga acttgagtta gaatcagaag aaggggccac aagaccaaag atacttacat   1020

cccgattgcc agttaagagc agaagcacta catcttcctg cagggggggc acgagcccca   1080

caaaagaaag taaggagcat ttctttgacc tttacagaaa ttccatagaa ttctttgagg   1140

agattagtga tgaggcttcc aaattagtgg ataggctgac acagtcagag agggagcagg   1200

aaatagtttc agacgatgaa agtagtagtg ccctggaagt atcagtaatt gaaaatctgc   1260

cacctgttga gaccgagcac tcagttcctg aggacatctt tgacacaagg cccatttggg   1320

atgagtctat tgagactctg attgaacgca tcc                                1353


<210>  2023
<211>  258
<212>  PRT
<213>  Homo sapiens

<400>  2023


Met Glu Asn Val Pro Phe Thr Glu Ser Lys Ser Lys Ile Pro Val Arg 
1               5                   10                  15      


Thr Met Pro Thr Ser Thr Pro Ala Pro Pro Ser Ala Glu Tyr Glu Ser 
            20                  25                  30          


Ser Val Ser Glu Asp Phe Leu Ser Ser Val Asp Glu Glu Asn Lys Ala 
        35                  40                  45              


Asp Glu Ala Lys Pro Lys Ser Lys Leu Pro Val Lys Val Pro Leu Gln 
    50                  55                  60                  


Arg Val Glu Gln Gln Leu Ser Asp Leu Asp Thr Ser Val Gln Lys Thr 
65                  70                  75                  80  


Val Ala Pro Gln Gly Gln Asp Met Ala Ser Ile Ala Pro Asp Asn Arg 
                85                  90                  95      


Ser Lys Ser Glu Ser Asp Ala Ser Ser Leu Asp Ser Lys Thr Lys Cys 
            100                 105                 110         


Pro Val Lys Thr Arg Ser Tyr Thr Glu Thr Glu Thr Glu Ser Arg Glu 
        115                 120                 125             


Arg Ala Glu Glu Leu Glu Leu Glu Ser Glu Glu Gly Ala Thr Arg Pro 
    130                 135                 140                 


Lys Ile Leu Thr Ser Arg Leu Pro Val Lys Ser Arg Ser Thr Thr Ser 
145                 150                 155                 160 


Ser Cys Arg Gly Gly Thr Ser Pro Thr Lys Glu Ser Lys Glu His Phe 
                165                 170                 175     


Phe Asp Leu Tyr Arg Asn Ser Ile Glu Phe Phe Glu Glu Ile Ser Asp 
            180                 185                 190         


Glu Ala Ser Lys Leu Val Asp Arg Leu Thr Gln Ser Glu Arg Glu Gln 
        195                 200                 205             


Glu Ile Val Ser Asp Asp Glu Ser Ser Ser Ala Leu Glu Val Ser Val 
    210                 215                 220                 


Ile Glu Asn Leu Pro Pro Val Glu Thr Glu His Ser Val Pro Glu Asp 
225                 230                 235                 240 


Ile Phe Asp Thr Arg Pro Ile Trp Asp Glu Ser Ile Glu Thr Leu Ile 
                245                 250                 255     


Glu Arg 
        

<210>  2024
<211>  479
<212>  DNA
<213>  Homo sapiens

<400>  2024
ggctcctctc tccggtccgt gcctccaaga tgacaaagaa aagaaggaac aatggtcgtg     60

ccaaaaaggg ccgcggccac gtgcagccta ttcgctgcac taactgtgcc cgatgcgtgc    120

ccaaggacaa ggccattaag aaattcgtca ttcgaaacat agtggaggcc gcagcagtca    180

gggacatttc tgaagcgagc gtcttcgatg cctatgtgct tcccaagctg tatgtgaagc    240

tacattactg tgtgagttgt gcaattcaca gcaaagtagt caggaatcga tctcgtgaag    300

cccgcaagga ccgaacaccc ccaccccgat ttagacctgc gggtgctgcc ccacgtcccc    360

caccaaagcc catgtaagga gctgagttct taaagactga agacaggcta ttctctggag    420

aaaaataaaa tggaaattgt acttaaaaaa aaaataaaaa aaaaaaataa ataaaacag     479


<210>  2025
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  2025


Met Thr Lys Lys Arg Arg Asn Asn Gly Arg Ala Lys Lys Gly Arg Gly 
1               5                   10                  15      


His Val Gln Pro Ile Arg Cys Thr Asn Cys Ala Arg Cys Val Pro Lys 
            20                  25                  30          


Asp Lys Ala Ile Lys Lys Phe Val Ile Arg Asn Ile Val Glu Ala Ala 
        35                  40                  45              


Ala Val Arg Asp Ile Ser Glu Ala Ser Val Phe Asp Ala Tyr Val Leu 
    50                  55                  60                  


Pro Lys Leu Tyr Val Lys Leu His Tyr Cys Val Ser Cys Ala Ile His 
65                  70                  75                  80  


Ser Lys Val Val Arg Asn Arg Ser Arg Glu Ala Arg Lys Asp Arg Thr 
                85                  90                  95      


Pro Pro Pro Arg Phe Arg Pro Ala Gly Ala Ala Pro Arg Pro Pro Pro 
            100                 105                 110         


Lys Pro Met 
        115 

<210>  2026
<211>  581
<212>  DNA
<213>  Homo sapiens

<400>  2026
acaccggcgt ggtactagtc acggagccgc acccctcgga aagcgcggag tcgatgacag     60

ccacttcaca ggctcacgcg ctcctagtgt gggcttgaag gggacgggga ccgattacca    120

aaggagagcg ctgagtacgg aagacacagg gcagcctttg tcttgggttt agcgctgatg    180

cgctcaaccc tgagtcgggt tcactgcaac tgttgtgtcc gatttcggtt ccctgcaacc    240

gccctcctgg gcgagagatg tcattgtgtt cctgcggcca gcgggactga gagctgggac    300

ttaagacgcc aggagggtcc tgcgctcacg gatgctttta caaaatctga gtcataaatt    360

acagatattc ttgatgaaaa ttcagaacat aggatttatt ttcaaaaaga aatgtacccc    420

aaaagaactc tgagagaata tactcaactg tcctgctgtg attaaacaag actgctgtat    480

tttatggggt ttcagcatgt tgcccaggct ggcctcgaac tcctggactc aagcgatcca    540

cctacctcag tttcccgaag tgctgggatt acaagcatga g                        581


<210>  2027
<211>  59
<212>  PRT
<213>  Homo sapiens

<400>  2027


Met Arg Ser Thr Leu Ser Arg Val His Cys Asn Cys Cys Val Arg Phe 
1               5                   10                  15      


Arg Phe Pro Ala Thr Ala Leu Leu Gly Glu Arg Cys His Cys Val Pro 
            20                  25                  30          


Ala Ala Ser Gly Thr Glu Ser Trp Asp Leu Arg Arg Gln Glu Gly Pro 
        35                  40                  45              


Ala Leu Thr Asp Ala Phe Thr Lys Ser Glu Ser 
    50                  55                  

<210>  2028
<211>  618
<212>  DNA
<213>  Homo sapiens

<400>  2028
ctgaaaacta cattggctga acagcactct tactcaagaa aacggattac agatggagtg     60

agagcctggg acaagcatca aagagtgatt tggtgaatac aggggatctg atacatgtga    120

cacaacggcc actagggcga caggctactc caacagcgag gatttttaaa gtaatataag    180

agtatatcta aaacagtcca ataactgaca gagagagaga aagtcaaaac aaataaacac    240

atgctggtga tagaaaacct ctgtagaaga cagctgatga tttaaataaa aatatactgt    300

gagaatacct gaagcaatta caagtccaac acaaagaaag gactttctgg agtaaacagc    360

attaaacaaa gtaattttaa aaattaggat ttgcaaagta aatgacgcag tggatgaatt    420

taaagagtgc ttggattctg ttgagacctc ctatagtaga ttgaaaaatc aagtagaaga    480

aatattttca taatggagaa aagatacaag gagataataa acataataca tcctggcaac    540

atgcctgaac accaaggata aaaaaaaaaa ctattccata tacagagaat acattaaatg    600

aaaaagttat cagactta                                                  618


<210>  2029
<211>  52
<212>  PRT
<213>  Homo sapiens

<400>  2029


Thr Ala Leu Leu Leu Lys Lys Thr Asp Tyr Arg Trp Ser Glu Ser Leu 
1               5                   10                  15      


Gly Gln Ala Ser Lys Ser Asp Leu Val Asn Thr Gly Asp Leu Ile His 
            20                  25                  30          


Val Thr Gln Arg Pro Leu Gly Arg Gln Ala Thr Pro Thr Ala Arg Ile 
        35                  40                  45              


Phe Lys Val Ile 
    50          

<210>  2030
<211>  743
<212>  DNA
<213>  Homo sapiens

<400>  2030
tgaaattgaa gatgttggtt ctgctgagga agaagaagaa aagaaggatg gtgacaagca     60

gaagaagaag aagattagga aaagtacatt gatcaagaag aactcaacaa aacaaagccc    120

atctggacca gaaatccaga tgatattact aatgaggagt acagagaatt ctacaagagc    180

ttgactaatg actgggaaga tcacttgtca gtgaagcatt tttcagttga aggacagttg    240

gaatacagag cccttctatt ttcccatgat gtgctccttt tgacctgttt gaaaacagaa    300

agaaaaagaa caatatcaaa ttgtatgtat gcagagtttt catcacggat aactgtgagg    360

agctaatccc tgaatacctg aacttcatta gagtgctggt agactcggag gatctccctc    420

taaatatttc ccataagatg ttacaacaaa gcaaaatttt gaaagttatc aggaagaatt    480

tggtcaaaaa atgcttagaa ctctttactg aactggcaga agataaagag aactacaaga    540

agttctatga gcagttctct gaaaacataa agcttggaat acatgaagac tctcaaaatc    600

agaagaagct ttcagagctg ttaagatcag ccgccaggat tagattgtca caggagcacg    660

agcctattgt ggaacctact gtgaactgtg cacgtgaggg atccaagttg cctgctcctt    720

atgagaatct aactaatgcc tga                                            743


<210>  2031
<211>  101
<212>  PRT
<213>  Homo sapiens

<400>  2031


Met Leu Gln Gln Ser Lys Ile Leu Lys Val Ile Arg Lys Asn Leu Val 
1               5                   10                  15      


Lys Lys Cys Leu Glu Leu Phe Thr Glu Leu Ala Glu Asp Lys Glu Asn 
            20                  25                  30          


Tyr Lys Lys Phe Tyr Glu Gln Phe Ser Glu Asn Ile Lys Leu Gly Ile 
        35                  40                  45              


His Glu Asp Ser Gln Asn Gln Lys Lys Leu Ser Glu Leu Leu Arg Ser 
    50                  55                  60                  


Ala Ala Arg Ile Arg Leu Ser Gln Glu His Glu Pro Ile Val Glu Pro 
65                  70                  75                  80  


Thr Val Asn Cys Ala Arg Glu Gly Ser Lys Leu Pro Ala Pro Tyr Glu 
                85                  90                  95      


Asn Leu Thr Asn Ala 
            100     

<210>  2032
<211>  496
<212>  DNA
<213>  Homo sapiens

<400>  2032
ttgttcttta gctctttgca ataaatcttg ctactgccca ctctttgggt ttacactgca     60

tttatgagct gtaacactca tggtgaagat ttacaggttc agtcctgaag ccagcgagac    120

aaagaaccca ctgggaagaa caaacaactc cagacgcccc aacttaagag ctgttaacac    180

ccgaagatct gcagcttcac ttttgagcca gcgagaccac gaacccacca gaaggaagaa    240

actctgaaca ggctggaacg tcagaaggaa caaactcagg acatgccacc tttaagaact    300

gtaacactca ctgtgagggt ctgcggcttc attcttgaag gctgtgagac caagaaccca    360

ccaatttcgg acacactggg accaccctcg ctgactggag cacttgaggc aatcattccc    420

agatagtgga acctcgaatg gcagacactg tggttctcct gcggggctga gaactgtgag    480

gagcagagca gacttc                                                    496


<210>  2033
<211>  47
<212>  PRT
<213>  Homo sapiens

<400>  2033


Met Pro Pro Leu Arg Thr Val Thr Leu Thr Val Arg Val Cys Gly Phe 
1               5                   10                  15      


Ile Leu Glu Gly Cys Glu Thr Lys Asn Pro Pro Ile Ser Asp Thr Leu 
            20                  25                  30          


Gly Pro Pro Ser Leu Thr Gly Ala Leu Glu Ala Ile Ile Pro Arg 
        35                  40                  45          

<210>  2034
<211>  5128
<212>  DNA
<213>  Homo sapiens

<400>  2034
gagcgggcgg gctgcgaggc cgcggggcat gcgggaggcg gaggggtggg gaccggggtg     60

ggctgcgccc tcccgctctg gcccattcca caccccgccg aaagcggaca ctgtcagctg    120

aatcactccc cttttaggag gagggagggg aaaaaggtgt ctagctcctt tctgcttaaa    180

aaagcacagg gagatcgcgg gcagctttgc agtcgctgcc ttctcgcgcc tgaccatgca    240

cccctgcatc ttcctgctgg gccacaggcg agcgctttat ttctggagct gagggctaaa    300

acttttttga cttttcttct cctcaacatc tgaatcatgc catgtgccca gaggagctgg    360

cttgcaaacc tttccgtggt ggctcagctc cttaactttg gggcgctttg ctatgggaga    420

cagcctcagc caggcccggt tcgcttcccg gacaggaggc aagagcattt tatcaagggc    480

ctgccagaat accacgtggt gggtccagtc cgagtagatg ccagtgggca ttttttgtca    540

tatggcttgc actatcccat cacgagcagc aggaggaaga gagatttgga tggctcagag    600

gactgggtgt actacagaat ttctcacgag gagaaggacc tgttttttaa cttgacggtc    660

aatcaaggat ttctttccaa tagctacatc atggagaaga gatatgggaa cctctcccat    720

gttaagatga tggcttcctc tgcccccctc tgccatctca gtggcacggt tctacagcag    780

ggcaccagag ttgggacggc agccctcagt gcctgccatg gactgactgg atttttccaa    840

ctaccacatg gagacttttt cattgaaccc gtgaagaagc atccactggt tgagggaggg    900

taccacccgc acatcgttta caggaggcag aaagttccag aaaccaagga gccaacctgt    960

ggattaaagg acagtgttaa catctcccag aagcaagagc tatggcggga gaagtgggag   1020

aggcacaact tgccaagcag aagcctctct cggcgttcca tcagcaagga gagatgggtg   1080

gagacactgg tggtggccga cacaaagatg attgaatacc atgggagtga gaatgtggag   1140

tcctacatcc tcaccatcat gaacatggtc actgggttgt tccataaccc aagcattggc   1200

aatgcaattc acattgttgt ggttcggctc attctactcg aagaagaaga gcaaggactg   1260

aaaatagttc accatgcaga aaagacactg tctagcttct gcaagtggca gaagagtatc   1320

aatcccaaga gtgacctcaa tcctgttcat cacgacgtgg ctgtccttct caccagaaag   1380

gacatctgtg ctggtttcaa tcgcccctgc gagaccctgg gcctgtctca cctttcagga   1440

atgtgtcagc ctcaccgcag ttgtaacatc aatgaagatt cgggactccc tctggctttc   1500

acaattgccc atgagctagg acacagcttc ggcatccagc atgatgggaa agaaaatgac   1560

tgtgagcctg tgggcagaca tccgtacatc atgtcccgcc agctccagta cgatcccact   1620

ccgctgacat ggtccaagtg cagcgaggag tacatcaccc gcttcttgga ccgaggctgg   1680

gggttctgtc ttgatgacat acctaaaaag aaaggcttga agtccaaggt cattgccccc   1740

ggagtgatct atgatgttca ccaccagtgc cagctacaat atggacccaa tgctaccttc   1800

tgccaggaag tagaaaacgt ctgccagaca ctgtggtgct ccgtgaaggg cttttgtcgc   1860

tctaagctgg acgctgctgc agatggaact caatgtggtg agaagaagtg gtgtatggca   1920

ggcaagtgca tcacagtggg gaagaaacca gagagcattc ctggaggctg gggccgctgg   1980

tcaccctggt cccactgttc caggacctgt ggggctggag tccagagcgc agagaggctc   2040

tgcaacaacc ccgagccaaa gtttggaggg aaatattgca ctggagaaag aaaacgctat   2100

cgcttgtgca acgtccaccc ctgtcgctca gaggcaccaa catttcggca gatgcagtgc   2160

agtgaatttg acactgttcc ctacaagaat gaactctacc actggtttcc catttttaac   2220

ccagcacatc cttgtgagct ctactgccga cccatagatg gccagttttc tgagaaaatg   2280

ctggatgctg tcattgatgg taccccttgc tttgaaggcg gcaacagcag aaatgtctgt   2340

attaatggca tatgtaagat ggttggctgt gactatgaga tcgattccaa tgccaccgag   2400

gatcgctgcg gtgtgtgcct gggagatggc tcttcctgcc agactgtgag aaagatgttt   2460

aagcagaagg aaggatctgg ttatgttgac attgggctca ttccaaaagg agcaagggac   2520

ataagagtga tggaaattga gggagctgga aacttcctgg ccatcaggag tgaagatcct   2580

gaaaaatatt acctgaatgg agggtttatt atccagtgga acgggaacta taagctggca   2640

gggactgtct ttcagtatga caggaaagga gacctggaaa agctgatggc cacaggtccc   2700

accaatgagt ctgtgtggat ccagcttcta ttccaggtga ctaaccctgg catcaagtat   2760

gagtacacaa tccagaaaga tggccttgac aatgatgttg agcagcagat gtacttctgg   2820

cagtacggcc actggacaga gtgcagtgtg acctgcggga caggtatccg ccgccaaact   2880

gcccattgca taaagaaggg ccgcgggatg gtgaaagcta cattctgtga cccagaaaca   2940

cagcccaatg ggagacagaa gaagtgccat gaaaaggctt gtccacccag gtggtgggca   3000

ggggagtggg aagcatgctc ggcgacatgc gggccccacg gggagaagaa gcgaaccgtg   3060

ctgtgcatcc agaccatggt ctctgacgag caggctctcc cgcccacaga ctgccagcac   3120

ctgctgaagc ccaagaccct cctttcctgc aacagagaca tcctgtgccc ctcggactgg   3180

acagtgggca actggagtga gtgttctgtt tcctgtggtg gtggagtgcg gattcgcagt   3240

gtcacatgtg ccaagaacca tgatgaacct tgcgatgtga caaggaaacc caacagccga   3300

gctctgtgtg gcctccagca atgcccttct agccggagag ttctgaaacc aaacaaaggc   3360

actatttcca atggaaaaaa cccaccaaca ctaaagcccg tccctccacc tacatccagg   3420

cccagaatgc tgaccacacc cacagggcct gagtctatga gcacaagcac tccagcaatc   3480

agcagcccta gtcctaccac agcctccaaa gaaggagacc tgggtgggaa acagtggcaa   3540

gatagctcaa cccaacctga gctgagctct cgctatctca tttccactgg aagcacttcc   3600

cagcccatcc tcacttccca atccttgagc attcagccaa gtgaggaaaa tgtttccagt   3660

tcagatactg gtcctacctc ggagggaggc cttgtagcta caacaacaag tggttctggc   3720

ttgtcatctt cccgcaaccc tatcacttgg cctgtgactc cattttacaa taccttgacc   3780

aaaggtccag aaatggagat tcacagtggc tcaggggaag aaagagaaca gcctgaggac   3840

aaagatgaaa gcaatcctgt aatatggacc aagatcagag tacctggaaa tgacgctcca   3900

gtggaaagta cagaaatgcc acttgcacct ccactaacac cagatctcag cagggagtcc   3960

tggtggccac ccttcagcac agtaatggaa ggactgctcc ccagccaaag gcccactact   4020

tccgaaactg ggacacccag agttgagggg atggttactg aaaagccagc caacactctg   4080

ctccctctgg gaggagacca ccagccagaa ccctcaggaa agacggcaaa ccgtaaccac   4140

ctgaaacttc caaacaacat gaaccaaaca aaaagttctg aaccagtcct gactgaggag   4200

gatgcaacaa gtctgattac tgagggcttt ttgctaaatg cctccaatta caagcagctc   4260

acaaacggcc acggctctgc acactggatc gtcggaaact ggagcgagtg ctccaccaca   4320

tgtggcctgg gggcctactg gagaagggtg gagtgcagca cccagatgga ttctgactgt   4380

gcggccatcc agagacctga ccctgcaaaa agatgccacc tccgtccctg tgctggctgg   4440

aaagtgggaa actggagcaa gtgctccaga aactgcagtg ggggcttcaa gatacgcgag   4500

attcagtgcg tggacagccg ggaccaccgg aacctgaggc catttcactg ccagttcctg   4560

gccggcattc ctcccccatt gagcatgagc tgtaacccgg agccctgtga ggcgtggcag   4620

gtggagcctt ggagccagtg ctccaggtcc tgtggaggtg gagttcagga gagaggagtg   4680

ttctgtccag gaggcctctg tgattggaca aaaagaccca catccaccat gtcttgcaat   4740

gagcacctgt gctgtcactg ggccactggg aactgggacc tgtgttccac ttcctgtgga   4800

ggtggctttc agaagaggac tgtccaatgt gtgccctcag agggcaataa aactgaagac   4860

caagaccaat gtctatgtga tcacaaaccc agacctccag aattcaaaaa atgcaaccag   4920

caggcctgca agaaaagtgc cgatttactt tgcactaagg acaaactgtc agccagtttc   4980

tgccagacac tgaaagccat gaagaaatgt tctgtgccca ccgtgagggc tgagtgctgc   5040

ttctcgtgtc cccagacaca catcacacac acccaaaggc aaagaaggca acggttgctc   5100

caaaagtcaa aagaactcta agcccaaa                                      5128


<210>  2035
<211>  1594
<212>  PRT
<213>  Homo sapiens

<400>  2035


Met Pro Cys Ala Gln Arg Ser Trp Leu Ala Asn Leu Ser Val Val Ala 
1               5                   10                  15      


Gln Leu Leu Asn Phe Gly Ala Leu Cys Tyr Gly Arg Gln Pro Gln Pro 
            20                  25                  30          


Gly Pro Val Arg Phe Pro Asp Arg Arg Gln Glu His Phe Ile Lys Gly 
        35                  40                  45              


Leu Pro Glu Tyr His Val Val Gly Pro Val Arg Val Asp Ala Ser Gly 
    50                  55                  60                  


His Phe Leu Ser Tyr Gly Leu His Tyr Pro Ile Thr Ser Ser Arg Arg 
65                  70                  75                  80  


Lys Arg Asp Leu Asp Gly Ser Glu Asp Trp Val Tyr Tyr Arg Ile Ser 
                85                  90                  95      


His Glu Glu Lys Asp Leu Phe Phe Asn Leu Thr Val Asn Gln Gly Phe 
            100                 105                 110         


Leu Ser Asn Ser Tyr Ile Met Glu Lys Arg Tyr Gly Asn Leu Ser His 
        115                 120                 125             


Val Lys Met Met Ala Ser Ser Ala Pro Leu Cys His Leu Ser Gly Thr 
    130                 135                 140                 


Val Leu Gln Gln Gly Thr Arg Val Gly Thr Ala Ala Leu Ser Ala Cys 
145                 150                 155                 160 


His Gly Leu Thr Gly Phe Phe Gln Leu Pro His Gly Asp Phe Phe Ile 
                165                 170                 175     


Glu Pro Val Lys Lys His Pro Leu Val Glu Gly Gly Tyr His Pro His 
            180                 185                 190         


Ile Val Tyr Arg Arg Gln Lys Val Pro Glu Thr Lys Glu Pro Thr Cys 
        195                 200                 205             


Gly Leu Lys Asp Ser Val Asn Ile Ser Gln Lys Gln Glu Leu Trp Arg 
    210                 215                 220                 


Glu Lys Trp Glu Arg His Asn Leu Pro Ser Arg Ser Leu Ser Arg Arg 
225                 230                 235                 240 


Ser Ile Ser Lys Glu Arg Trp Val Glu Thr Leu Val Val Ala Asp Thr 
                245                 250                 255     


Lys Met Ile Glu Tyr His Gly Ser Glu Asn Val Glu Ser Tyr Ile Leu 
            260                 265                 270         


Thr Ile Met Asn Met Val Thr Gly Leu Phe His Asn Pro Ser Ile Gly 
        275                 280                 285             


Asn Ala Ile His Ile Val Val Val Arg Leu Ile Leu Leu Glu Glu Glu 
    290                 295                 300                 


Glu Gln Gly Leu Lys Ile Val His His Ala Glu Lys Thr Leu Ser Ser 
305                 310                 315                 320 


Phe Cys Lys Trp Gln Lys Ser Ile Asn Pro Lys Ser Asp Leu Asn Pro 
                325                 330                 335     


Val His His Asp Val Ala Val Leu Leu Thr Arg Lys Asp Ile Cys Ala 
            340                 345                 350         


Gly Phe Asn Arg Pro Cys Glu Thr Leu Gly Leu Ser His Leu Ser Gly 
        355                 360                 365             


Met Cys Gln Pro His Arg Ser Cys Asn Ile Asn Glu Asp Ser Gly Leu 
    370                 375                 380                 


Pro Leu Ala Phe Thr Ile Ala His Glu Leu Gly His Ser Phe Gly Ile 
385                 390                 395                 400 


Gln His Asp Gly Lys Glu Asn Asp Cys Glu Pro Val Gly Arg His Pro 
                405                 410                 415     


Tyr Ile Met Ser Arg Gln Leu Gln Tyr Asp Pro Thr Pro Leu Thr Trp 
            420                 425                 430         


Ser Lys Cys Ser Glu Glu Tyr Ile Thr Arg Phe Leu Asp Arg Gly Trp 
        435                 440                 445             


Gly Phe Cys Leu Asp Asp Ile Pro Lys Lys Lys Gly Leu Lys Ser Lys 
    450                 455                 460                 


Val Ile Ala Pro Gly Val Ile Tyr Asp Val His His Gln Cys Gln Leu 
465                 470                 475                 480 


Gln Tyr Gly Pro Asn Ala Thr Phe Cys Gln Glu Val Glu Asn Val Cys 
                485                 490                 495     


Gln Thr Leu Trp Cys Ser Val Lys Gly Phe Cys Arg Ser Lys Leu Asp 
            500                 505                 510         


Ala Ala Ala Asp Gly Thr Gln Cys Gly Glu Lys Lys Trp Cys Met Ala 
        515                 520                 525             


Gly Lys Cys Ile Thr Val Gly Lys Lys Pro Glu Ser Ile Pro Gly Gly 
    530                 535                 540                 


Trp Gly Arg Trp Ser Pro Trp Ser His Cys Ser Arg Thr Cys Gly Ala 
545                 550                 555                 560 


Gly Val Gln Ser Ala Glu Arg Leu Cys Asn Asn Pro Glu Pro Lys Phe 
                565                 570                 575     


Gly Gly Lys Tyr Cys Thr Gly Glu Arg Lys Arg Tyr Arg Leu Cys Asn 
            580                 585                 590         


Val His Pro Cys Arg Ser Glu Ala Pro Thr Phe Arg Gln Met Gln Cys 
        595                 600                 605             


Ser Glu Phe Asp Thr Val Pro Tyr Lys Asn Glu Leu Tyr His Trp Phe 
    610                 615                 620                 


Pro Ile Phe Asn Pro Ala His Pro Cys Glu Leu Tyr Cys Arg Pro Ile 
625                 630                 635                 640 


Asp Gly Gln Phe Ser Glu Lys Met Leu Asp Ala Val Ile Asp Gly Thr 
                645                 650                 655     


Pro Cys Phe Glu Gly Gly Asn Ser Arg Asn Val Cys Ile Asn Gly Ile 
            660                 665                 670         


Cys Lys Met Val Gly Cys Asp Tyr Glu Ile Asp Ser Asn Ala Thr Glu 
        675                 680                 685             


Asp Arg Cys Gly Val Cys Leu Gly Asp Gly Ser Ser Cys Gln Thr Val 
    690                 695                 700                 


Arg Lys Met Phe Lys Gln Lys Glu Gly Ser Gly Tyr Val Asp Ile Gly 
705                 710                 715                 720 


Leu Ile Pro Lys Gly Ala Arg Asp Ile Arg Val Met Glu Ile Glu Gly 
                725                 730                 735     


Ala Gly Asn Phe Leu Ala Ile Arg Ser Glu Asp Pro Glu Lys Tyr Tyr 
            740                 745                 750         


Leu Asn Gly Gly Phe Ile Ile Gln Trp Asn Gly Asn Tyr Lys Leu Ala 
        755                 760                 765             


Gly Thr Val Phe Gln Tyr Asp Arg Lys Gly Asp Leu Glu Lys Leu Met 
    770                 775                 780                 


Ala Thr Gly Pro Thr Asn Glu Ser Val Trp Ile Gln Leu Leu Phe Gln 
785                 790                 795                 800 


Val Thr Asn Pro Gly Ile Lys Tyr Glu Tyr Thr Ile Gln Lys Asp Gly 
                805                 810                 815     


Leu Asp Asn Asp Val Glu Gln Gln Met Tyr Phe Trp Gln Tyr Gly His 
            820                 825                 830         


Trp Thr Glu Cys Ser Val Thr Cys Gly Thr Gly Ile Arg Arg Gln Thr 
        835                 840                 845             


Ala His Cys Ile Lys Lys Gly Arg Gly Met Val Lys Ala Thr Phe Cys 
    850                 855                 860                 


Asp Pro Glu Thr Gln Pro Asn Gly Arg Gln Lys Lys Cys His Glu Lys 
865                 870                 875                 880 


Ala Cys Pro Pro Arg Trp Trp Ala Gly Glu Trp Glu Ala Cys Ser Ala 
                885                 890                 895     


Thr Cys Gly Pro His Gly Glu Lys Lys Arg Thr Val Leu Cys Ile Gln 
            900                 905                 910         


Thr Met Val Ser Asp Glu Gln Ala Leu Pro Pro Thr Asp Cys Gln His 
        915                 920                 925             


Leu Leu Lys Pro Lys Thr Leu Leu Ser Cys Asn Arg Asp Ile Leu Cys 
    930                 935                 940                 


Pro Ser Asp Trp Thr Val Gly Asn Trp Ser Glu Cys Ser Val Ser Cys 
945                 950                 955                 960 


Gly Gly Gly Val Arg Ile Arg Ser Val Thr Cys Ala Lys Asn His Asp 
                965                 970                 975     


Glu Pro Cys Asp Val Thr Arg Lys Pro Asn Ser Arg Ala Leu Cys Gly 
            980                 985                 990         


Leu Gln Gln Cys Pro Ser Ser Arg  Arg Val Leu Lys Pro  Asn Lys Gly 
        995                 1000                 1005             


Thr Ile  Ser Asn Gly Lys Asn  Pro Pro Thr Leu Lys  Pro Val Pro 
    1010                 1015                 1020             


Pro Pro  Thr Ser Arg Pro Arg  Met Leu Thr Thr Pro  Thr Gly Pro 
    1025                 1030                 1035             


Glu Ser  Met Ser Thr Ser Thr  Pro Ala Ile Ser Ser  Pro Ser Pro 
    1040                 1045                 1050             


Thr Thr  Ala Ser Lys Glu Gly  Asp Leu Gly Gly Lys  Gln Trp Gln 
    1055                 1060                 1065             


Asp Ser  Ser Thr Gln Pro Glu  Leu Ser Ser Arg Tyr  Leu Ile Ser 
    1070                 1075                 1080             


Thr Gly  Ser Thr Ser Gln Pro  Ile Leu Thr Ser Gln  Ser Leu Ser 
    1085                 1090                 1095             


Ile Gln  Pro Ser Glu Glu Asn  Val Ser Ser Ser Asp  Thr Gly Pro 
    1100                 1105                 1110             


Thr Ser  Glu Gly Gly Leu Val  Ala Thr Thr Thr Ser  Gly Ser Gly 
    1115                 1120                 1125             


Leu Ser  Ser Ser Arg Asn Pro  Ile Thr Trp Pro Val  Thr Pro Phe 
    1130                 1135                 1140             


Tyr Asn  Thr Leu Thr Lys Gly  Pro Glu Met Glu Ile  His Ser Gly 
    1145                 1150                 1155             


Ser Gly  Glu Glu Arg Glu Gln  Pro Glu Asp Lys Asp  Glu Ser Asn 
    1160                 1165                 1170             


Pro Val  Ile Trp Thr Lys Ile  Arg Val Pro Gly Asn  Asp Ala Pro 
    1175                 1180                 1185             


Val Glu  Ser Thr Glu Met Pro  Leu Ala Pro Pro Leu  Thr Pro Asp 
    1190                 1195                 1200             


Leu Ser  Arg Glu Ser Trp Trp  Pro Pro Phe Ser Thr  Val Met Glu 
    1205                 1210                 1215             


Gly Leu  Leu Pro Ser Gln Arg  Pro Thr Thr Ser Glu  Thr Gly Thr 
    1220                 1225                 1230             


Pro Arg  Val Glu Gly Met Val  Thr Glu Lys Pro Ala  Asn Thr Leu 
    1235                 1240                 1245             


Leu Pro  Leu Gly Gly Asp His  Gln Pro Glu Pro Ser  Gly Lys Thr 
    1250                 1255                 1260             


Ala Asn  Arg Asn His Leu Lys  Leu Pro Asn Asn Met  Asn Gln Thr 
    1265                 1270                 1275             


Lys Ser  Ser Glu Pro Val Leu  Thr Glu Glu Asp Ala  Thr Ser Leu 
    1280                 1285                 1290             


Ile Thr  Glu Gly Phe Leu Leu  Asn Ala Ser Asn Tyr  Lys Gln Leu 
    1295                 1300                 1305             


Thr Asn  Gly His Gly Ser Ala  His Trp Ile Val Gly  Asn Trp Ser 
    1310                 1315                 1320             


Glu Cys  Ser Thr Thr Cys Gly  Leu Gly Ala Tyr Trp  Arg Arg Val 
    1325                 1330                 1335             


Glu Cys  Ser Thr Gln Met Asp  Ser Asp Cys Ala Ala  Ile Gln Arg 
    1340                 1345                 1350             


Pro Asp  Pro Ala Lys Arg Cys  His Leu Arg Pro Cys  Ala Gly Trp 
    1355                 1360                 1365             


Lys Val  Gly Asn Trp Ser Lys  Cys Ser Arg Asn Cys  Ser Gly Gly 
    1370                 1375                 1380             


Phe Lys  Ile Arg Glu Ile Gln  Cys Val Asp Ser Arg  Asp His Arg 
    1385                 1390                 1395             


Asn Leu  Arg Pro Phe His Cys  Gln Phe Leu Ala Gly  Ile Pro Pro 
    1400                 1405                 1410             


Pro Leu  Ser Met Ser Cys Asn  Pro Glu Pro Cys Glu  Ala Trp Gln 
    1415                 1420                 1425             


Val Glu  Pro Trp Ser Gln Cys  Ser Arg Ser Cys Gly  Gly Gly Val 
    1430                 1435                 1440             


Gln Glu  Arg Gly Val Phe Cys  Pro Gly Gly Leu Cys  Asp Trp Thr 
    1445                 1450                 1455             


Lys Arg  Pro Thr Ser Thr Met  Ser Cys Asn Glu His  Leu Cys Cys 
    1460                 1465                 1470             


His Trp  Ala Thr Gly Asn Trp  Asp Leu Cys Ser Thr  Ser Cys Gly 
    1475                 1480                 1485             


Gly Gly  Phe Gln Lys Arg Thr  Val Gln Cys Val Pro  Ser Glu Gly 
    1490                 1495                 1500             


Asn Lys  Thr Glu Asp Gln Asp  Gln Cys Leu Cys Asp  His Lys Pro 
    1505                 1510                 1515             


Arg Pro  Pro Glu Phe Lys Lys  Cys Asn Gln Gln Ala  Cys Lys Lys 
    1520                 1525                 1530             


Ser Ala  Asp Leu Leu Cys Thr  Lys Asp Lys Leu Ser  Ala Ser Phe 
    1535                 1540                 1545             


Cys Gln  Thr Leu Lys Ala Met  Lys Lys Cys Ser Val  Pro Thr Val 
    1550                 1555                 1560             


Arg Ala  Glu Cys Cys Phe Ser  Cys Pro Gln Thr His  Ile Thr His 
    1565                 1570                 1575             


Thr Gln  Arg Gln Arg Arg Gln  Arg Leu Leu Gln Lys  Ser Lys Glu 
    1580                 1585                 1590             


Leu 
    

<210>  2036
<211>  932
<212>  DNA
<213>  Homo sapiens

<400>  2036
cactcccctt ttaggaggag ggaggggaaa aaggtgtcta gctcctttct gcttaaaaaa     60

gcacagggag atcgcgggca gctttgcagt cgctgccttc tcgcgcctga ccatgcaccc    120

ctgcatcttc ctgctgggcc acaggcgagc gctttatttc tggagctgag ggctaaaact    180

tttttgactt ttcttctcct caacatctga atcatgccat gtgcccagag gagctggctt    240

gcaaaccttt ccgtggtggc tcagctcctt aactttgggg cgctttgcta tgggagacag    300

cctcagccag gcccggttcg cttcccggac aggaggcaag agcattttat caagggcctg    360

ccagaatacc acgtggtggg tccagtccga gtagatgcca gtgggcattt tttgtcatat    420

ggcttgcact atcccatcac gagcagcagg aggaagagag atttggatgg ctcagaggac    480

tgggtgtact acagaatttc tcacgaggag aaggacctgt tttttaactt gacggtcaat    540

caaggatttc tttccaatag ctacatcatg gagaagagat atgggaacct ctcccatgtt    600

aagatgatgg cttcctctgc ccccctctgc catctcagtg gcacggttct acagcagggc    660

accagagttg ggacggcagc cctcagtgcc tgccatggac tgactggatt tttccaacta    720

ccacatggag actttttcat tgaacccgtg aagaagcatc cactggttga gggagggtac    780

cacccgcaca tcgtttacag gaggcagaaa gttccagaaa ccaaggagcc aacctgtgga    840

ttaaagggta ttgtgactca catgtcctcc tgggttgaag aatctgtttt gttcttttgg    900

ttgttttatt aaaacatgac ctattcttac tc                                  932


<210>  2037
<211>  232
<212>  PRT
<213>  Homo sapiens

<400>  2037


Met Pro Cys Ala Gln Arg Ser Trp Leu Ala Asn Leu Ser Val Val Ala 
1               5                   10                  15      


Gln Leu Leu Asn Phe Gly Ala Leu Cys Tyr Gly Arg Gln Pro Gln Pro 
            20                  25                  30          


Gly Pro Val Arg Phe Pro Asp Arg Arg Gln Glu His Phe Ile Lys Gly 
        35                  40                  45              


Leu Pro Glu Tyr His Val Val Gly Pro Val Arg Val Asp Ala Ser Gly 
    50                  55                  60                  


His Phe Leu Ser Tyr Gly Leu His Tyr Pro Ile Thr Ser Ser Arg Arg 
65                  70                  75                  80  


Lys Arg Asp Leu Asp Gly Ser Glu Asp Trp Val Tyr Tyr Arg Ile Ser 
                85                  90                  95      


His Glu Glu Lys Asp Leu Phe Phe Asn Leu Thr Val Asn Gln Gly Phe 
            100                 105                 110         


Leu Ser Asn Ser Tyr Ile Met Glu Lys Arg Tyr Gly Asn Leu Ser His 
        115                 120                 125             


Val Lys Met Met Ala Ser Ser Ala Pro Leu Cys His Leu Ser Gly Thr 
    130                 135                 140                 


Val Leu Gln Gln Gly Thr Arg Val Gly Thr Ala Ala Leu Ser Ala Cys 
145                 150                 155                 160 


His Gly Leu Thr Gly Phe Phe Gln Leu Pro His Gly Asp Phe Phe Ile 
                165                 170                 175     


Glu Pro Val Lys Lys His Pro Leu Val Glu Gly Gly Tyr His Pro His 
            180                 185                 190         


Ile Val Tyr Arg Arg Gln Lys Val Pro Glu Thr Lys Glu Pro Thr Cys 
        195                 200                 205             


Gly Leu Lys Gly Ile Val Thr His Met Ser Ser Trp Val Glu Glu Ser 
    210                 215                 220                 


Val Leu Phe Phe Trp Leu Phe Tyr 
225                 230         

<210>  2038
<211>  707
<212>  DNA
<213>  Homo sapiens

<400>  2038
ttgtaaggaa atctgggctg ggacctcagg agcctaggct ttctcagaat tcagtgctta     60

aggtgatgag tccttcattc ttatagaaag agcattttat caagggcctg ccagaatacc    120

acgtggtggg tccagtccga gtagatgcca gtgggcattt tttgtcatat ggcttgcact    180

atcccatcac gagcagcagg aggaagagag atttggatgg ctcagaggac tgggtgtact    240

acagaatttc tcacgaggag aaggacctgt tttttaactt gacggtcaat caaggatttc    300

tttccaatag ctacatcatg gagaagagat atgggaacct ctcccatgtt aagatgatgg    360

cttcctctgc ccccctctgc catctcagtg gcacggttct acagcagggc accagagttg    420

ggacggcagc cctcagtgcc tgccatggac tggtgagtgt gggctctggc atctccttcc    480

tctgccctgg cccctagagt ctcagctggt agacctacta ccaacaggtt cacagatgca    540

ctgacatatg ggagttgaac ccctgtgatg tgatgatcct ggcctccaaa gtggttggcg    600

agaaagtatt taataaataa aagagatcga cttgagagat acaaagagta agggcactga    660

gggttcagag gaggcagaca gaactccaac cagcaacatc agtttgg                  707


<210>  2039
<211>  59
<212>  PRT
<213>  Homo sapiens

<400>  2039


Met Glu Lys Arg Tyr Gly Asn Leu Ser His Val Lys Met Met Ala Ser 
1               5                   10                  15      


Ser Ala Pro Leu Cys His Leu Ser Gly Thr Val Leu Gln Gln Gly Thr 
            20                  25                  30          


Arg Val Gly Thr Ala Ala Leu Ser Ala Cys His Gly Leu Val Ser Val 
        35                  40                  45              


Gly Ser Gly Ile Ser Phe Leu Cys Pro Gly Pro 
    50                  55                  

<210>  2040
<211>  2533
<212>  DNA
<213>  Homo sapiens

<400>  2040
ggggagttat gcgccagtgc cccagtgacc gcgggacacg gagaggggaa gtctgcgttg     60

tacataagga cctagggact ccgagcttgg cctgagaacc cttggacgcc gagtgcttgc    120

cttacgggct gcactcctca actctgctcc aaagcagccg ctgagctcaa ctcctgcgtc    180

cagggcgttc gctgcgcgcc aggacgcgct tagtacccag ttcctgggct ctctcttcag    240

tagctgcttt gaaagctccc acgcacgtcc cgcaggctag cctggcaaca aaactggggt    300

aaaccgtgtt atcttaggtc ttgtccccca gaacatgacc tagaggtacc tgcgcatgca    360

gatggccgat gcagccacga tagccaccat gaataaggca gcaggcgggg acaagctagc    420

agaactcttc agtctggtcc cggaccttct ggaggcggcc aacacgagtg gtaacgcgtc    480

gctgcagctt ccggacttgt ggtgggagct ggggctggag ttgccggacg gcgcgccgcc    540

aggacatccc ccgggcagcg gcggggcaga gagcgcggac acagaggccc gggtgcggat    600

tctcatcagc gtggtgtact gggtggtgtg cgccctgggg ttggcgggca acctgctggt    660

tctctacctg atgaagagca tgcagggctg gcgcaagtcc tctatcaacc tcttcgtcac    720

caacctggcg ctgacggact ttcagtttgt gctcaccctg cccttctggg cggtggagaa    780

cgctcttgac ttcaaatggc ccttcggcaa ggccatgtgt aagatcgtgt ccatggtgac    840

gtccatgaac atgtacgcca gcgtgttctt cctcactgcc atgagtgtga cgcgctacca    900

ttcggtggcc tcggctctga agagccaccg gacccgagga cacggccggg gcgactgctg    960

cggccggagc ctgggggaca gctgctgctt ctcggccaag gcgctgtgtg tgtggatctg   1020

ggctttggcc gcgctggcct cgctgcccag tgccattttc tccaccacgg tcaaggtgat   1080

gggcgaggag ctgtgcctgg tgcgtttccc ggacaagttg ctgggccgcg acaggcagtt   1140

ctggctgggc ctctaccact cgcagaaggt gctgctgggc ttcgtgctgc cgctgggcat   1200

cattatcttg tgctacctgc tgctggtgcg cttcatcgcc gaccgccgcg cggcggggac   1260

caaaggaggg gccgcggtag ccggaggacg cccgaccgga gccagcgccc ggagactgtc   1320

gaaggtcacc aaatcagtga ccatcgttgt cctgtccttc ttcctgtgtt ggctgcccaa   1380

ccaggcgctc accacctgga gcatcctcat caagttcaac gcggtgccct tcagccagga   1440

gtatttcctg tgccaggtat acgcgttccc tgtgagcgtg tgcctagcgc actccaacag   1500

ctgcctcaac cccgtcctct actgcctcgt gcgccgcgag ttccgcaagg cgctcaagag   1560

cctgctgtgg cgcatcgcgt ctccttcgat caccagcatg cgccccttca ccgccactac   1620

caagccggag cacgaggatc aggggctgca ggccccggcg ccgccccacg cggccgcgga   1680

gccggacctg ctctactacc cacctggcgt cgtggtctac agcggggggc gctacgacct   1740

gctgcccagc agctctgcct actgacgcag gcctcaggcc cagggcgcgc cgtcggggca   1800

aggtggcctt ccccgggcgg taaagaggtg aaaggatgaa ggagggctgg ggggggcccc   1860

atttaagaag taggtgggag gaggatgggc agagcatgga ggaggagcct gtggataggc   1920

cgaggacctt ctctggagag gagatgcttc gaaatcgggt ggagagagga aattggcaaa   1980

gggatagaga cgagccccac gggccagaca gccaacctcc gctccgcacc ccacagcctc   2040

tccttactct tcccacgctg agtagtgtgg gggcgcccag aagcgaagac aagcagcaaa   2100

aatgtagaga aattggcacg gggagcgggg cttagccaaa tgatgcacag acaattgtgc   2160

ccgtttattc cagcgacttc tgcggagagg gcagccgtcg gcacaaacac tcctttgcgt   2220

cttggcaaac gagactgcag cagcgccaag gtcctacttg ctgcggggct gccccaggaa   2280

tctagagctg gtaggcaaga aacgcttttg gagttaagaa aaagaactga ccatcctggt   2340

ccgcccacag gagaaacggc aaaggaaagc cacctccaat ggagtcatta tgacaattat   2400

cattccggac tgggccagcg ggaacaccct gagcccgacc tagctgcaca gccccggagc   2460

tcagacgtta gcagggggat aacacctgtc accagcttgg gagagccatt ctctggggag   2520

tgtcgtcgct gcg                                                      2533


<210>  2041
<211>  469
<212>  PRT
<213>  Homo sapiens

<400>  2041


Met Gln Met Ala Asp Ala Ala Thr Ile Ala Thr Met Asn Lys Ala Ala 
1               5                   10                  15      


Gly Gly Asp Lys Leu Ala Glu Leu Phe Ser Leu Val Pro Asp Leu Leu 
            20                  25                  30          


Glu Ala Ala Asn Thr Ser Gly Asn Ala Ser Leu Gln Leu Pro Asp Leu 
        35                  40                  45              


Trp Trp Glu Leu Gly Leu Glu Leu Pro Asp Gly Ala Pro Pro Gly His 
    50                  55                  60                  


Pro Pro Gly Ser Gly Gly Ala Glu Ser Ala Asp Thr Glu Ala Arg Val 
65                  70                  75                  80  


Arg Ile Leu Ile Ser Val Val Tyr Trp Val Val Cys Ala Leu Gly Leu 
                85                  90                  95      


Ala Gly Asn Leu Leu Val Leu Tyr Leu Met Lys Ser Met Gln Gly Trp 
            100                 105                 110         


Arg Lys Ser Ser Ile Asn Leu Phe Val Thr Asn Leu Ala Leu Thr Asp 
        115                 120                 125             


Phe Gln Phe Val Leu Thr Leu Pro Phe Trp Ala Val Glu Asn Ala Leu 
    130                 135                 140                 


Asp Phe Lys Trp Pro Phe Gly Lys Ala Met Cys Lys Ile Val Ser Met 
145                 150                 155                 160 


Val Thr Ser Met Asn Met Tyr Ala Ser Val Phe Phe Leu Thr Ala Met 
                165                 170                 175     


Ser Val Thr Arg Tyr His Ser Val Ala Ser Ala Leu Lys Ser His Arg 
            180                 185                 190         


Thr Arg Gly His Gly Arg Gly Asp Cys Cys Gly Arg Ser Leu Gly Asp 
        195                 200                 205             


Ser Cys Cys Phe Ser Ala Lys Ala Leu Cys Val Trp Ile Trp Ala Leu 
    210                 215                 220                 


Ala Ala Leu Ala Ser Leu Pro Ser Ala Ile Phe Ser Thr Thr Val Lys 
225                 230                 235                 240 


Val Met Gly Glu Glu Leu Cys Leu Val Arg Phe Pro Asp Lys Leu Leu 
                245                 250                 255     


Gly Arg Asp Arg Gln Phe Trp Leu Gly Leu Tyr His Ser Gln Lys Val 
            260                 265                 270         


Leu Leu Gly Phe Val Leu Pro Leu Gly Ile Ile Ile Leu Cys Tyr Leu 
        275                 280                 285             


Leu Leu Val Arg Phe Ile Ala Asp Arg Arg Ala Ala Gly Thr Lys Gly 
    290                 295                 300                 


Gly Ala Ala Val Ala Gly Gly Arg Pro Thr Gly Ala Ser Ala Arg Arg 
305                 310                 315                 320 


Leu Ser Lys Val Thr Lys Ser Val Thr Ile Val Val Leu Ser Phe Phe 
                325                 330                 335     


Leu Cys Trp Leu Pro Asn Gln Ala Leu Thr Thr Trp Ser Ile Leu Ile 
            340                 345                 350         


Lys Phe Asn Ala Val Pro Phe Ser Gln Glu Tyr Phe Leu Cys Gln Val 
        355                 360                 365             


Tyr Ala Phe Pro Val Ser Val Cys Leu Ala His Ser Asn Ser Cys Leu 
    370                 375                 380                 


Asn Pro Val Leu Tyr Cys Leu Val Arg Arg Glu Phe Arg Lys Ala Leu 
385                 390                 395                 400 


Lys Ser Leu Leu Trp Arg Ile Ala Ser Pro Ser Ile Thr Ser Met Arg 
                405                 410                 415     


Pro Phe Thr Ala Thr Thr Lys Pro Glu His Glu Asp Gln Gly Leu Gln 
            420                 425                 430         


Ala Pro Ala Pro Pro His Ala Ala Ala Glu Pro Asp Leu Leu Tyr Tyr 
        435                 440                 445             


Pro Pro Gly Val Val Val Tyr Ser Gly Gly Arg Tyr Asp Leu Leu Pro 
    450                 455                 460                 


Ser Ser Ser Ala Tyr 
465                 

<210>  2042
<211>  446
<212>  DNA
<213>  Homo sapiens

<400>  2042
cagggctctg tactcattgc tcttcatccc actgctgtgt gctattgtct ttgtgatctt     60

catgattgga ttttgcttct tcaaggaaga tataaaagag cccaagtaat tctggaaacc    120

agcattttac ccttgacctc ctgcttttca tcctactggt cctcgccaga agtcgctggt    180

tgcctggtat aagaaaacaa tcataattat ctcattaata cttggacctg gcctccctgc    240

taatcagatc aactaagtac caaggaagct attctctgat ataatgaaga gaaaagaatc    300

ttgaacctgg taagagtggt ttcaagccaa aacagataat ttctacagaa tacaataaat    360

gctctttggc tctgtgtagt gatattgcct cccagacatt ttaagactta aaacctaaag    420

aatgggttta ttttaaatta ataaat                                         446


<210>  2043
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  2043


Pro Pro Ala Phe His Pro Thr Gly Pro Arg Gln Lys Ser Leu Val Ala 
1               5                   10                  15      


Trp Tyr Lys Lys Thr Ile Ile Ile Ile Ser Leu Ile Leu Gly Pro Gly 
            20                  25                  30          


Leu Pro Ala Asn Gln Ile Asn 
        35                  

<210>  2044
<211>  1463
<212>  DNA
<213>  Homo sapiens

<400>  2044
gcttctctgg ctgaaggagg aggattaaag gtatcaagag gaagggttga gggccacctg     60

ccagccccta ctcattggtc cttagtggct cagggctctg tactcattgc tcttcatccc    120

actgctgtgt gctattgtct ttgtgatctt catgattgga ttttgcttct tcaaggaaga    180

tataaaagag cccaagtaat tctggaaacc agcattttac ccttgacctc ctgcttttca    240

tcctactggt cctcgccaga agtcgctggt tgcctggtat aagaaaacaa tcataattat    300

ctcattaata cttggacctg gcctccctgc taatcaggtt tgtactgctg agatttcaaa    360

ggagaacaga aatctactaa gaagaaataa attggttctc aggctataaa tagttctagg    420

aagctgccca gggacaaaaa tttgcctgct ggtgaaataa aagaccatgt aaactgtaga    480

tttatttgga gagtatagtt ccatgaattt aactggtcta gactctgggc ctctggaagg    540

cagagaccat gctctcagcc ttgcctttag taccttgtct gtaacaggct atcagatatg    600

ttgattgtgt caaagataag caaattctga aatgagtaat ttttttcatt ctctatcctc    660

tctgaattca cttagtgcct ctcagaatgt gtctgagtgg aaagggattt gcacaggata    720

tgtccaaaca ggttattgta actttggagg taaactcttg tctatcattc catgcacttc    780

attattattt atatccattt ctttctttct ttctttgttt atttatttaa gtaattggtc    840

atgaaataga cttgcatgct gaatactgaa atgtggtgtt tgacacttgt aaattattcc    900

agattatata tgagactata atagataaaa gtgatttaga taataaagtg atctgtaatt    960

gaagtaaatg agagctgggt gctgtggcta atgccttgta ctcccagcac tttggaaggc   1020

tgaggcagta ggatcgcttg ggtccaggag tttgagacta gcgtggcaac atagctagac   1080

cctgtctcta caaaaagtaa aaaattaacc aagtgtggtg atgcgcacct gtagtctcag   1140

ctacacagga ggctgaggtg ggaggatcac ttgagctcca gatgttgagg ctgaagtgag   1200

ccataatcat cctactgcac tccagcctgg gtgacagagg aagaccatgt ctcaaaaaaa   1260

aaaaaaaaaa aaagagaagt aaatgaaaac ttagagaaat agtagttgca acttccaaac   1320

caaagcttgt aattctggtc actatgactt ggaaatattt tccagaacaa ctgtgactct   1380

tgccgttgct ctataaaata ctggcaaggt ccaaaaggga attttccccc actgtgtata   1440

atattattag acagatggta ttg                                           1463


<210>  2045
<211>  70
<212>  PRT
<213>  Homo sapiens

<400>  2045


Met Ser Asn Phe Phe His Ser Leu Ser Ser Leu Asn Ser Leu Ser Ala 
1               5                   10                  15      


Ser Gln Asn Val Ser Glu Trp Lys Gly Ile Cys Thr Gly Tyr Val Gln 
            20                  25                  30          


Thr Gly Tyr Cys Asn Phe Gly Gly Lys Leu Leu Ser Ile Ile Pro Cys 
        35                  40                  45              


Thr Ser Leu Leu Phe Ile Ser Ile Ser Phe Phe Leu Ser Leu Phe Ile 
    50                  55                  60                  


Tyr Leu Ser Asn Trp Ser 
65                  70  

<210>  2046
<211>  3888
<212>  DNA
<213>  Homo sapiens

<400>  2046
cttctccttt ctcggccaac cctaggtaga atcctaaaac aactgccctc tcttccacga     60

tctagatgtt gcggcccgcg gacaggaggt tcaagaaata gtacactccg agcggcaggc    120

agcgaggcgg aaacggtcgc cggtttcagt ggtggcccca ctggaagccg agttcaggag    180

cggctaagcg gtcgccgggg aaagcaccgg ggcttcccag ggtcccctcc gagttcccac    240

tccgcacctc cgagggcgtg aaaaccacgg gagccgcccc accccgcgcg cccagccccg    300

ccccagccca gacaccgccc cccgccagtc ttccctgcgg cgcccaggga ggacgcgctc    360

cgcccccttc caatccggcc aatgggcgcc cgggcagcgc gcggtttgcc tccgcctccg    420

ccagggaaac ttggaggagg agaaaagttt gtacagaggg tggaaaggcg agagcggagc    480

tccaagcccg gcagcccgag aggaagatga acagccccag gccagagcct ctggcagagt    540

ggaccccgag ccgcccccag gtagccagga gcggcctcag cggcagccgc aaactccagt    600

agccgcccgt gctgcccgtg gctggggcgg agggcagcca gagctgggga ccaaggctcc    660

gcgccacctg cgcgcacagc ctcacacctg aacgctgtcc tcccgcagac gagaccggcg    720

ggcactgcaa agctgggact cgtctttgaa ggaaaaaaaa tagcgagtaa gaaatccagc    780

accattcttc actgacccat cccgctgcac ctcttgtttc ccaagttttt gaaagctggc    840

aactctgacc tcggtgtcca aaaatcgaca gccactgaga ccggctttga gaagccgaag    900

atttggcagt ttccagactg agcaggacaa ggtgaaagca ggttggaggc gggtccagga    960

catctgaggg ctgaccctgg gggctcgtga ggctgccacc gctgctgccg ctacagaccc   1020

agccttgcac tccaaggctg cgcaccgcca gccactatca tgtccactcc cggggtcaat   1080

tcgtccgcct ccttgagccc cgaccggctg aacagcccag tgaccatccc ggcggtgatg   1140

ttcatcttcg gggtggtggg caacctggtg gccatcgtgg tgctgtgcaa gtcgcgcaag   1200

gagcagaagg agacgacctt ctacacgctg gtatgtgggc tggctgtcac cgacctgttg   1260

ggcactttgt tggtgagccc ggtgaccatc gccacgtaca tgaagggcca atggcccggg   1320

ggccagccgc tgtgcgagta cagcaccttc attctgctct tcttcagcct gtccggcctc   1380

agcatcatct gcgccatgag tgtcgagcgc tacctggcca tcaaccatgc ctatttctac   1440

agccactacg tggacaagcg attggcgggc ctcacgctct ttgcagtcta tgcgtccaac   1500

gtgctctttt gcgcgctgcc caacatgggt ctcggtagct cgcggctgca gtacccagac   1560

acctggtgct tcatcgactg gaccaccaac gtgacggcgc acgccgccta ctcctacatg   1620

tacgcgggct tcagctcctt cctcattctc gccaccgtcc tctgcaacgt gcttgtgtgc   1680

ggcgcgctgc tccgcatgca ccgccagttc atgcgccgca cctcgctggg caccgagcag   1740

caccacgcgg ccgcggccgc ctcggttgcc tcccggggcc accccgctgc ctccccagcc   1800

ttgccgcgcc tcagcgactt tcggcgccgc cggagcttcc gccgcatcgc gggcgccgag   1860

atccagatgg tcatcttact cattgccacc tccctggtgg tgctcatctg ctccatcccg   1920

ctcgtggtgc gagtattcgt caaccagtta tatcagccaa gtttggagcg agaagtcagt   1980

aaaaatccag atttgcaggc catccgaatt gcttctgtga accccatcct agacccctgg   2040

atatatatcc tcctgagaaa gacagtgctc agtaaagcaa tagagaagat caaatgcctc   2100

ttctgccgca ttggcgggtc ccgcagggag cgctccggac agcactgctc agacagtcaa   2160

aggacatctt ctgccatgtc aggccactct cgctccttca tctcccggga gctgaaggag   2220

atcagcagta catctcagac cctcctgcca gacctctcac tgccagacct cagtgaaaat   2280

ggccttggag gcaggaattt gcttccaggt gtgcctggca tgggcctggc ccaggaagac   2340

accacctcac tgaggacttt gcgaatatca gagacctcag actcttcaca gggtcaggac   2400

tcagagagtg tcttactggt ggatgaggct ggtgggagcg gcagggctgg gcctgcccct   2460

aaggggagct ccctgcaagt cacatttccc agtgaaacac tgaacttatc agaaaaatgt   2520

atataatagg caaggaaaga aatacagtac tgtttctgga cccttataaa atcctgtgca   2580

atagacacat acatgtcaca tttagctgtg ctcagaaggg ctatcatcat cctacaactc   2640

acattagaga acatcctggc ttttgagcac ttttcaaaca atcaagttga ctcacgtggg   2700

tcctgaggcc tgcagcacgt cggatgctac cccactatga cagaggattg tggtcacaac   2760

ttgatggctg cgaagaccta ccctccgttt ttctactaga taggaggatg gtagaagttt   2820

ggctgctgtc ataacatcca gagctttgtc gtatttggca cacagcagag gcccagatat   2880

tagaaaggct ctattccaat aaactatgag gactgcctta tggatgattt aagtgtctca   2940

ctaaagcatg aaatgtgaat ttttattgtt gtacatacga tttaaggtat ttaaagtatt   3000

ttcttctctg tgagaaggtt tattgttaat acaaggtata ataaaattat cgcaacccct   3060

ctccttccag tataaccagc tgaagttgca gatgttagat atttttcata aacaagttcg   3120

agtcaaagtt gaaaattcat agtaagattg atatctataa aatagatata aatttttaag   3180

agaaagaatt tagtattatc aaagggataa agaaaaaaat actatttaag atgtgaaaat   3240

tacagtccaa aatactgttc tttccaggct atgtataaaa tacatagtga aaattgttta   3300

gtgatattac atttatttat ccagaaaact gtgatttcag gagaacctaa catgctggtg   3360

aatattttca actttttccc tcactaattg gtacttttaa aaacataaca taaatttttt   3420

gaagtcttta ataaataacc cataattgaa gtgtataata taaaaaattt taaaaatcta   3480

agcagcttat tgtttctctg aaagtgtgtg tagttttact ttcctaagga attaccaaga   3540

atatccttta aaatttaaaa ggatggcaag ttgcatcaga aagctttatt ttgagatgta   3600

aaaagattcc caaacgtggt tacattagcc attcatgtat gtcagaagtg cagaattggg   3660

gcacttaatg gtcaccttgt aacagttttg tgtaactccc agtgatgctg tacacatatt   3720

tgaagggtct ttctcaaaga aatattaagc atgttttgtt gctcagtgtt tttgtgaatt   3780

gcttggttgt aattaaattc tgagcctgat attgatatgg ttttaagaag cagttgtacc   3840

aagtgaaatt attttggaga ttataataaa tatatacatt caatctga                3888


<210>  2047
<211>  488
<212>  PRT
<213>  Homo sapiens

<400>  2047


Met Ser Thr Pro Gly Val Asn Ser Ser Ala Ser Leu Ser Pro Asp Arg 
1               5                   10                  15      


Leu Asn Ser Pro Val Thr Ile Pro Ala Val Met Phe Ile Phe Gly Val 
            20                  25                  30          


Val Gly Asn Leu Val Ala Ile Val Val Leu Cys Lys Ser Arg Lys Glu 
        35                  40                  45              


Gln Lys Glu Thr Thr Phe Tyr Thr Leu Val Cys Gly Leu Ala Val Thr 
    50                  55                  60                  


Asp Leu Leu Gly Thr Leu Leu Val Ser Pro Val Thr Ile Ala Thr Tyr 
65                  70                  75                  80  


Met Lys Gly Gln Trp Pro Gly Gly Gln Pro Leu Cys Glu Tyr Ser Thr 
                85                  90                  95      


Phe Ile Leu Leu Phe Phe Ser Leu Ser Gly Leu Ser Ile Ile Cys Ala 
            100                 105                 110         


Met Ser Val Glu Arg Tyr Leu Ala Ile Asn His Ala Tyr Phe Tyr Ser 
        115                 120                 125             


His Tyr Val Asp Lys Arg Leu Ala Gly Leu Thr Leu Phe Ala Val Tyr 
    130                 135                 140                 


Ala Ser Asn Val Leu Phe Cys Ala Leu Pro Asn Met Gly Leu Gly Ser 
145                 150                 155                 160 


Ser Arg Leu Gln Tyr Pro Asp Thr Trp Cys Phe Ile Asp Trp Thr Thr 
                165                 170                 175     


Asn Val Thr Ala His Ala Ala Tyr Ser Tyr Met Tyr Ala Gly Phe Ser 
            180                 185                 190         


Ser Phe Leu Ile Leu Ala Thr Val Leu Cys Asn Val Leu Val Cys Gly 
        195                 200                 205             


Ala Leu Leu Arg Met His Arg Gln Phe Met Arg Arg Thr Ser Leu Gly 
    210                 215                 220                 


Thr Glu Gln His His Ala Ala Ala Ala Ala Ser Val Ala Ser Arg Gly 
225                 230                 235                 240 


His Pro Ala Ala Ser Pro Ala Leu Pro Arg Leu Ser Asp Phe Arg Arg 
                245                 250                 255     


Arg Arg Ser Phe Arg Arg Ile Ala Gly Ala Glu Ile Gln Met Val Ile 
            260                 265                 270         


Leu Leu Ile Ala Thr Ser Leu Val Val Leu Ile Cys Ser Ile Pro Leu 
        275                 280                 285             


Val Val Arg Val Phe Val Asn Gln Leu Tyr Gln Pro Ser Leu Glu Arg 
    290                 295                 300                 


Glu Val Ser Lys Asn Pro Asp Leu Gln Ala Ile Arg Ile Ala Ser Val 
305                 310                 315                 320 


Asn Pro Ile Leu Asp Pro Trp Ile Tyr Ile Leu Leu Arg Lys Thr Val 
                325                 330                 335     


Leu Ser Lys Ala Ile Glu Lys Ile Lys Cys Leu Phe Cys Arg Ile Gly 
            340                 345                 350         


Gly Ser Arg Arg Glu Arg Ser Gly Gln His Cys Ser Asp Ser Gln Arg 
        355                 360                 365             


Thr Ser Ser Ala Met Ser Gly His Ser Arg Ser Phe Ile Ser Arg Glu 
    370                 375                 380                 


Leu Lys Glu Ile Ser Ser Thr Ser Gln Thr Leu Leu Pro Asp Leu Ser 
385                 390                 395                 400 


Leu Pro Asp Leu Ser Glu Asn Gly Leu Gly Gly Arg Asn Leu Leu Pro 
                405                 410                 415     


Gly Val Pro Gly Met Gly Leu Ala Gln Glu Asp Thr Thr Ser Leu Arg 
            420                 425                 430         


Thr Leu Arg Ile Ser Glu Thr Ser Asp Ser Ser Gln Gly Gln Asp Ser 
        435                 440                 445             


Glu Ser Val Leu Leu Val Asp Glu Ala Gly Gly Ser Gly Arg Ala Gly 
    450                 455                 460                 


Pro Ala Pro Lys Gly Ser Ser Leu Gln Val Thr Phe Pro Ser Glu Thr 
465                 470                 475                 480 


Leu Asn Leu Ser Glu Lys Cys Ile 
                485             

<210>  2048
<211>  2234
<212>  DNA
<213>  Homo sapiens

<400>  2048
gcctcccggg gccaccccgc tgcctcccca gccttgccgc gcctcagcga ctttcggcgc     60

cgccggagct tccgccgcat cgcgggcgcc gagatccaga tggtcatctt actcattgcc    120

acctccctgg tggtgctcat ctgctccatc ccgctcgtga tatgcttttg tttactgtag    180

gcaaactgga agtggagtca taaaacaact gatgggatgt cagatgagtg tgaagcacat    240

ctatacatac aagagaaatg ccacaaattt gggtgcgagt attcgtcaac cagttatatc    300

agccaagttt ggagcgagaa gtcagtaaaa atccagattt gcaggccatc cgaattgctt    360

ctgtgaaccc catcctagac ccctggatat atatcctcct gagaaagaca gtgctcagta    420

aagcaataga gaagatcaaa tgcctcttct gccgcattgg cgggtcccgc agggagcgct    480

ccggacagca ctgctcagac agtcaaagga catcttctgc catgtcaggc cactctcgct    540

ccttcatctc ccgggagctg aaggagatca gcagtacatc tcagaccctc ctgccagacc    600

tctcactgcc agacctcagt gaaaatggcc ttggaggcag gaatttgctt ccaggtgtgc    660

ctggcatggg cctggcccag gaagacacca cctcactgag gactttgcga atatcagaga    720

cctcagactc ttcacagggt caggactcag agagtgtctt actggtggat gaggctggtg    780

ggagcggcag ggctgggcct gcccctaagg ggagctccct gcaagtcaca tttcccagtg    840

aaacactgaa cttatcagaa aaatgtatat aataggcaag gaaagaaata cagtactgtt    900

tctggaccct tataaaatcc tgtgcaatag acacatacat gtcacattta gctgtgctca    960

gaagggctat catcatccta caactcacat tagagaacat cctggctttt gagcactttt   1020

caaacaatca agttgactca cgtgggtcct gaggcctgca gcacgtcgga tgctacccca   1080

ctatgacaga ggattgtggt cacaacttga tggctgcgaa gacctaccct ccgtttttct   1140

actagatagg aggatggtag aagtttggct gctgtcataa catccagagc tttgtcgtat   1200

ttggcacaca gcagaggccc agatattaga aaggctctat tccaataaac tatgaggact   1260

gccttatgga tgatttaagt gtctcactaa agcatgaaat gtgaattttt attgttgtac   1320

atacgattta aggtatttaa agtattttct tctctgtgag aaggtttatt gttaatacaa   1380

ggtataataa aattatcgca acccctctcc ttccagtata accagctgaa gttgcagatg   1440

ttagatattt ttcataaaca agttcgagtc aaagttgaaa attcatagta agattgatat   1500

ctataaaata gatataaatt tttaagagaa agaatttagt attatcaaag ggataaagaa   1560

aaaaatacta tttaagatgt gaaaattaca gtccaaaata ctgttctttc caggctatgt   1620

ataaaataca tagtgaaaat tgtttagtga tattacattt atttatccag aaaactgtga   1680

tttcaggaga acctaacatg ctggtgaata ttttcaactt tttccctcac taattggtac   1740

ttttaaaaac ataacataaa ttttttgaag tctttaataa ataacccata attgaagtgt   1800

ataatataaa aaattttaaa aatctaagca gcttattgtt tctctgaaag tgtgtgtagt   1860

tttactttcc taaggaatta ccaagaatat cctttaaaat ttaaaaggat ggcaagttgc   1920

atcagaaagc tttattttga gatgtaaaaa gattcccaaa cgtggttaca ttagccattc   1980

atgtatgtca gaagtgcaga attggggcac ttaatggtca ccttgtaaca gttttgtgta   2040

actcccagtg atgctgtaca catatttgaa gggtctttct caaagaaata ttaagcatgt   2100

tttgttgctc agtgtttttg tgaattgctt ggttgtaatt aaattctgag cctgatattg   2160

atatggtttt aagaagcagt tgtaccaagt gaaattattt tggagattat aataaatata   2220

tacattcaat ctga                                                     2234


<210>  2049
<211>  204
<212>  PRT
<213>  Homo sapiens

<400>  2049


Met Pro Gln Ile Trp Val Arg Val Phe Val Asn Gln Leu Tyr Gln Pro 
1               5                   10                  15      


Ser Leu Glu Arg Glu Val Ser Lys Asn Pro Asp Leu Gln Ala Ile Arg 
            20                  25                  30          


Ile Ala Ser Val Asn Pro Ile Leu Asp Pro Trp Ile Tyr Ile Leu Leu 
        35                  40                  45              


Arg Lys Thr Val Leu Ser Lys Ala Ile Glu Lys Ile Lys Cys Leu Phe 
    50                  55                  60                  


Cys Arg Ile Gly Gly Ser Arg Arg Glu Arg Ser Gly Gln His Cys Ser 
65                  70                  75                  80  


Asp Ser Gln Arg Thr Ser Ser Ala Met Ser Gly His Ser Arg Ser Phe 
                85                  90                  95      


Ile Ser Arg Glu Leu Lys Glu Ile Ser Ser Thr Ser Gln Thr Leu Leu 
            100                 105                 110         


Pro Asp Leu Ser Leu Pro Asp Leu Ser Glu Asn Gly Leu Gly Gly Arg 
        115                 120                 125             


Asn Leu Leu Pro Gly Val Pro Gly Met Gly Leu Ala Gln Glu Asp Thr 
    130                 135                 140                 


Thr Ser Leu Arg Thr Leu Arg Ile Ser Glu Thr Ser Asp Ser Ser Gln 
145                 150                 155                 160 


Gly Gln Asp Ser Glu Ser Val Leu Leu Val Asp Glu Ala Gly Gly Ser 
                165                 170                 175     


Gly Arg Ala Gly Pro Ala Pro Lys Gly Ser Ser Leu Gln Val Thr Phe 
            180                 185                 190         


Pro Ser Glu Thr Leu Asn Leu Ser Glu Lys Cys Ile 
        195                 200                 

<210>  2050
<211>  446
<212>  DNA
<213>  Homo sapiens

<400>  2050
ttggtatttt acgccttgat tcttttgagg cttcttgact tgttcctagt aattcaactc     60

atctgtgacc tcacttgact cttctcctgt tgacctaact ccaagacctt ggatagtcgt    120

caagtcagag ttgtccctca ttggagtccc atgcccctcg ggaatgagct ggtcttctta    180

tttctgctac ttccagttaa tgtggagaaa agccatgaga tatttatcct tgctgcatat    240

gtggccatgg atttcggagt gtagaagctg aggtcagctg gaggtctaat tgttcagatt    300

ttagtgtgta gagttgctgt ggttaaacgt tcttaggaaa agtgactggt gttctcttct    360

gtccttctct tccatggtgg gaaatggggt tgatggcctt cttgtctgtt atatcctttt    420

gagatggtag gatttaatag tagcca                                         446


<210>  2051
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  2051


Met Pro Leu Gly Asn Glu Leu Val Phe Leu Phe Leu Leu Leu Pro Val 
1               5                   10                  15      


Asn Val Glu Lys Ser His Glu Ile Phe Ile Leu Ala Ala Tyr Val Ala 
            20                  25                  30          


Met Asp Phe Gly Val 
        35          

<210>  2052
<211>  5509
<212>  DNA
<213>  Homo sapiens

<400>  2052
gggatttgtg gtcccggaga agagattggc ggaggggaaa gactgagtcg tctttccttt     60

gcccgcttct gtggactgtt cgaacgccca ggggtgggcc aaacccgttt cttaggaaac    120

caggaatcca gggaaggcag aatggcttcc tttgggtgga agaggaaaat tggtgagaag    180

gtctcaaagg tcacttccca gcagtttgaa gctgaagctg ctgatgagaa ggatgtagtt    240

gacaacgatg aagggaactg gcttcatgcc attaaacgta ggaaagaaat tcttcttgaa    300

ggctgtgctg agaaaagtaa acagctgaag gatgaaggag ccagtttggc tgaaaataaa    360

aggacttgga gaagatatcg ggaggcaatt cagaagtggg atgaagcact acagttaact    420

ccaaatgatg ctaccctata cgagatgaaa tcacaggtgc taatgtctct tcatgaaatg    480

ttcccagcag tacatgcagc agaaatggcc gtccagcaaa atccacattc atgggagtct    540

tggcagactt tgggacgtgc tcaacttggt ttaggagaga taatcctggc aattcgaagt    600

tttcaagtag cccttcacat ctatccaatg aaccctgaaa tatggaaaga agacctctct    660

tgggcaagaa cgctccagga gcagcagaag gtagcacaga ggattaaaaa aagtgaagca    720

ccagctgaag taacacactt ttcaccaaag tcaattccag actatgactt tgaaagtgat    780

gagattgttg ctgtttgtgc agctattgct gagaaagaga agacagtttc agcaaataaa    840

acaatggtta ttgtgtctgc ttctggggcc atagagactg taactgaaaa ggaggatggt    900

gctacaccac cagatggctc tgtttttatc aaagcccgat gaagcagtat gcataggatt    960

atttgaatct gtctttttga ttgcctcttg aagttttgac atagagacat ttactctgga   1020

gatagatagg agaacgcctg gttgtaaaat atgtttttca gatgaggcat ataaaaacta   1080

aaatggcagg attattgtat agtgtttgga atatgctttg ataagttatg atttatattt   1140

ctcaaggtta aaattctgag taaaatggtc tttgattaat aaacttagtt taatctgaat   1200

atgtaaatga atacatttta aagacaaaac ttgaaaaatg tattcttgaa tagtgaataa   1260

tttgatcaat gttactgaaa tgctgtctca acttttgttt tatgataaag gaagtgtgtg   1320

atttccctcc ctctgagaaa tatactgcgc ttaatatttg ctgtcttttt cttgcttcat   1380

tagagtaagt ctgtcagaaa gcttgaatat ttttgacatt cattttgatt caaagttgtc   1440

atttggttat atgtggaatc tttgaaagtt tggctgaaaa tgcacacaaa tgtgtacatt   1500

ctgaacattt tctgaagttt ctcttaattc tgatttgtgt ttctgttttg actttgaagt   1560

tgtaacaatg atagttgtct ccttcagtat ttggtaaaag tgtaaagtat tgataaatat   1620

gagaatgatg gttttatttt ttaattgtta cagtaagtaa tccttaccac aaatgagtca   1680

tttttaaaat atgcattttt aaatgaatgg cttttacaga taggttaatg acaattgtac   1740

tgctatatta tcccagtcaa aaccaatact ttcttttctt tattttacaa agctttaaaa   1800

accctggaaa caacttactt cttgcttgtg tctttccatt tgatgactgg gaattacttt   1860

tctagataac tttttttgaa actactcagt gaaatgaaaa ataattacaa ttttaaatag   1920

ctaattatat ctttctaaaa ataaaaaagt agggctgtta ttagagtgcc aatgaataaa   1980

taacttaagc acaaaataca tagaaattgg aatgtgattt atagtacaat ctcatgagta   2040

tgaaaaggct atattaaaaa aaattttatt gaaagtccac agtcatattc acaaaccaat   2100

actgtcattg ctaatctgaa ctattatttt tatactatat attgtagtac aataatatag   2160

aactgttggg ttctgttact tctgacactc aggaagatac tattggtgta ttaattttat   2220

ctttgttaga gatgaaagta gcccacttta tgttaaagat cttactactg ttggagctta   2280

taagtaatga tctacatttt ttatgaagat ggtttttaaa acttttgttt tattggaatg   2340

catatctctt ttcagggttg gagaaattag cacttgcctt gaaaagaata ttctttcctt   2400

aagttatatc atcagaaaat tagctctggt tagagaggtt agtttcagag tgctccaaaa   2460

aatatgttaa ttattttatt ttgtttaata aagaacattc tcaaaacgta aataggtatc   2520

tagagaagtg agtactcaac atttggtata ttgttttgag taatggatgt ttgttttttg   2580

tgtaatttgt gaataaatag tttttttctg cattttgaag attttcctat tattttatgt   2640

tgttagcttt tgaaaaatta gattgatcta cttagtgtct ttcttatatg aacttaatat   2700

atttaaagta ccttgcatgg tgcctcacac atgaagtaat gccagctatt tcagtaaatg   2760

ctagctattt ctatgaagaa cttgagttag tttggagata tttaacctca atttcctctg   2820

attttaaaaa aggagaactt tttttgtaat cctttcctta tctgaaagta agaagtctct   2880

gattccagta ttataggaga gatagtggga tttttcttga cagggtctat agctcaagtc   2940

ccaaagaggc aagactcagg atggaatgca tgtggccact aggccctgtt ataagaacct   3000

agtgtttcct ctgtactggc atggtaggcc aagttagtct ctttcttacc cagatataag   3060

acataaaata gtttagacat aagacagagg agaaaaagaa acagtaagtt atggagaagg   3120

aaggcagctc atttctgcag gcccctcaaa atgcttattt tagctcatac tcttctatgc   3180

gtgaagagaa aaatgcaccc attattttac aaggatgtga atactgatat acaaacatag   3240

actaagcttg ttaattttaa taacaaatct ttatgaatct gaagagaatt gatgttcatg   3300

ataatgatat agatgtttaa tatactttct gaaataacac tgtttactgt tcaagttata   3360

ttgactataa tttacattat tcttgtttga gaattgtatg gcatagacac tcattagtca   3420

gagtgtctag acatccagac catgcctgat aacacaagaa tcatatatca ttctctagaa   3480

aacaggctgt ttggttatag agtatttatc ttaaatatat taacagacac tacataaaca   3540

ttgaaaagcc atgcaagtta tagctcacag gagccagatc tactgcaact ggggcctaca   3600

tacaaaattt tatggcagtg gtttcagtat gacaatcttt tgaattgatg ccgtatggta   3660

aaactataaa gattttttaa aagctctgtc tcagctagaa tttttaagat tataactgaa   3720

cagtatagcc cttttagttg tttgaaaatt acataatgat tcaaaagctt gtttcactgc   3780

ctttcccagc actaagaaaa ttaacaatca tttcttttaa tttccttgaa tcagagccat   3840

tctaaagtga ctctggacca gcaattctga gctatgattt catgatacat gtattaatat   3900

ctaaatgagt tgtgagttga cataagaacc atagttccat aataattatc ttcaaatcaa   3960

tggatatctt aaatgtgttt ttttcttcct tagagattat tattaaactg atgtatttga   4020

taataaagaa ttttaggact gagaaagtta agtttttctt accaataata agatattgaa   4080

atatataaat tataaaacag aaataaaatg aaataaagga ggttatccct aaagtcattt   4140

accttagtca cttgcaatta aatatggtta cttcggaaga agaagtgtgg ccctaaagct   4200

actgtaacat gaatcatgcc ctaatgtgca ctatatatga actactttgg tcagaaggca   4260

gcggcgggta aggatggctt cctctcacag tgcttcttag gctatccatt taccaaggaa   4320

ttctaatctc tttctctcac ttcaccagga aaggagggag tttaagatat agaactgggc   4380

atgctagcct cttttttccc ttttgtggat ttgtcataac tgcagagaac cgatgttgtg   4440

gtctcttgcc agctacattg tgaaccttgc agtgaaagtt ctttgcctct gcaaagggag   4500

atttgtgctt gtgcagaact gcccatgcct tagtaagcag gtctgtctaa ttctaagttc   4560

aatatctggt ggctattgtt ggcataaact taaagtacat cctctaacct agcctttttc   4620

agcagtaaac ttaaaatatt gaatctccat ctgtctgtgt ctcaagtggt tcagaggtca   4680

ggagaggaga gggacattat tttatgactc cctcaaactt taacaaagac tagtgcagat   4740

tatatttcga agtaagcatg agatatatta aaaaccacat gtgggaattc tttcctaatt   4800

ttagaggttt tttttaaata atggaaattc tattgaaatt gagtagtgtt aattacaagg   4860

caacaggtaa acatttgttc aggatattta aaaggtctgc tgagttggaa ttgtgacaga   4920

ccacattgtt gactctagat tgaattggaa gggaagaatg tgaaatgaat taggatatcc   4980

tctgttcacc tctattaact ttcttaaatg agtataactt agaaataata aaatgcaagt   5040

attttaacgt tatagttggg agagttttga caaatgtaaa cacccacttc accaccacta   5100

ccatcctgat atagtgtgtg tccatcaccc aaaaagttct ctaaagccct tttgcagttg   5160

gttcccctcc acctgaacag ccatccctag tcaactactt ttctgctttc tgtggctata   5220

cgttagattt gacttcagaa ttctagagtt tgaaataaat aggccatata atatgcactc   5280

tttttgtgtc tgactttttt tttgcttaac atgatgcttt tgaaacccat ccatgttgag   5340

attcatccat gttatcatgt gtatcaataa taagttcctt tttattgctg aatagtattc   5400

tagtatatag atataccaca atttgtttag ctgttcacct attgatggac atttaggttg   5460

tttcaagttt tgatctatta tgaataaagc tgctatatat ataaatcac               5509


<210>  2053
<211>  266
<212>  PRT
<213>  Homo sapiens

<400>  2053


Met Ala Ser Phe Gly Trp Lys Arg Lys Ile Gly Glu Lys Val Ser Lys 
1               5                   10                  15      


Val Thr Ser Gln Gln Phe Glu Ala Glu Ala Ala Asp Glu Lys Asp Val 
            20                  25                  30          


Val Asp Asn Asp Glu Gly Asn Trp Leu His Ala Ile Lys Arg Arg Lys 
        35                  40                  45              


Glu Ile Leu Leu Glu Gly Cys Ala Glu Lys Ser Lys Gln Leu Lys Asp 
    50                  55                  60                  


Glu Gly Ala Ser Leu Ala Glu Asn Lys Arg Thr Trp Arg Arg Tyr Arg 
65                  70                  75                  80  


Glu Ala Ile Gln Lys Trp Asp Glu Ala Leu Gln Leu Thr Pro Asn Asp 
                85                  90                  95      


Ala Thr Leu Tyr Glu Met Lys Ser Gln Val Leu Met Ser Leu His Glu 
            100                 105                 110         


Met Phe Pro Ala Val His Ala Ala Glu Met Ala Val Gln Gln Asn Pro 
        115                 120                 125             


His Ser Trp Glu Ser Trp Gln Thr Leu Gly Arg Ala Gln Leu Gly Leu 
    130                 135                 140                 


Gly Glu Ile Ile Leu Ala Ile Arg Ser Phe Gln Val Ala Leu His Ile 
145                 150                 155                 160 


Tyr Pro Met Asn Pro Glu Ile Trp Lys Glu Asp Leu Ser Trp Ala Arg 
                165                 170                 175     


Thr Leu Gln Glu Gln Gln Lys Val Ala Gln Arg Ile Lys Lys Ser Glu 
            180                 185                 190         


Ala Pro Ala Glu Val Thr His Phe Ser Pro Lys Ser Ile Pro Asp Tyr 
        195                 200                 205             


Asp Phe Glu Ser Asp Glu Ile Val Ala Val Cys Ala Ala Ile Ala Glu 
    210                 215                 220                 


Lys Glu Lys Thr Val Ser Ala Asn Lys Thr Met Val Ile Val Ser Ala 
225                 230                 235                 240 


Ser Gly Ala Ile Glu Thr Val Thr Glu Lys Glu Asp Gly Ala Thr Pro 
                245                 250                 255     


Pro Asp Gly Ser Val Phe Ile Lys Ala Arg 
            260                 265     

<210>  2054
<211>  5365
<212>  DNA
<213>  Homo sapiens

<400>  2054
gggatttgtg gtcccggaga agagattggc ggaggggaaa gactgagtcg tctttccttt     60

gcccgcttct gtggactgtt cgaacgccca ggggtgggcc aaacccgttt cttaggaaac    120

caggaatcca gggaaggcag aatggcttcc tttgggtgga agaggaaaat tggtgagaag    180

gtctcaaagg tcacttccca gcagtttgaa gctgaagctg ctgatgagaa ggatgtagtt    240

gacaacgatg aagggaactg gcttcatgcc attaaacgta ggaaagaaat tcttcttgaa    300

ggctgtgctg agaaaagtaa acagctgaag gatgaaggag ccagtttggc tgaaaataaa    360

agatatcggg aggcaattca gaagtgggat gaagcactac agttaactcc aaatgatgct    420

accctatacg agatgaaatc acaggcaatt cgaagttttc aagtagccct tcacatctat    480

ccaatgaacc ctgaaatatg gaaagaagac ctctcttggg caagaacgct ccaggagcag    540

cagaaggtag cacagaggat taaaaaaagt gaagcaccag ctgaagtaac acacttttca    600

ccaaagtcaa ttccagacta tgactttgaa agtgatgaga ttgttgctgt ttgtgcagct    660

attgctgaga aagagaagac agtttcagca aataaaacaa tggttattgt gtctgcttct    720

ggggccatag agactgtaac tgaaaaggag gatggtgcta caccaccaga tggctctgtt    780

tttatcaaag cccgatgaag cagtatgcat aggattattt gaatctgtct ttttgattgc    840

ctcttgaagt tttgacatag agacatttac tctggagata gataggagaa cgcctggttg    900

taaaatatgt ttttcagatg aggcatataa aaactaaaat ggcaggatta ttgtatagtg    960

tttggaatat gctttgataa gttatgattt atatttctca aggttaaaat tctgagtaaa   1020

atggtctttg attaataaac ttagtttaat ctgaatatgt aaatgaatac attttaaaga   1080

caaaacttga aaaatgtatt cttgaatagt gaataatttg atcaatgtta ctgaaatgct   1140

gtctcaactt ttgttttatg ataaaggaag tgtgtgattt ccctccctct gagaaatata   1200

ctgcgcttaa tatttgctgt ctttttcttg cttcattaga gtaagtctgt cagaaagctt   1260

gaatattttt gacattcatt ttgattcaaa gttgtcattt ggttatatgt ggaatctttg   1320

aaagtttggc tgaaaatgca cacaaatgtg tacattctga acattttctg aagtttctct   1380

taattctgat ttgtgtttct gttttgactt tgaagttgta acaatgatag ttgtctcctt   1440

cagtatttgg taaaagtgta aagtattgat aaatatgaga atgatggttt tattttttaa   1500

ttgttacagt aagtaatcct taccacaaat gagtcatttt taaaatatgc atttttaaat   1560

gaatggcttt tacagatagg ttaatgacaa ttgtactgct atattatccc agtcaaaacc   1620

aatactttct tttctttatt ttacaaagct ttaaaaaccc tggaaacaac ttacttcttg   1680

cttgtgtctt tccatttgat gactgggaat tacttttcta gataactttt tttgaaacta   1740

ctcagtgaaa tgaaaaataa ttacaatttt aaatagctaa ttatatcttt ctaaaaataa   1800

aaaagtaggg ctgttattag agtgccaatg aataaataac ttaagcacaa aatacataga   1860

aattggaatg tgatttatag tacaatctca tgagtatgaa aaggctatat taaaaaaaat   1920

tttattgaaa gtccacagtc atattcacaa accaatactg tcattgctaa tctgaactat   1980

tatttttata ctatatattg tagtacaata atatagaact gttgggttct gttacttctg   2040

acactcagga agatactatt ggtgtattaa ttttatcttt gttagagatg aaagtagccc   2100

actttatgtt aaagatctta ctactgttgg agcttataag taatgatcta cattttttat   2160

gaagatggtt tttaaaactt ttgttttatt ggaatgcata tctcttttca gggttggaga   2220

aattagcact tgccttgaaa agaatattct ttccttaagt tatatcatca gaaaattagc   2280

tctggttaga gaggttagtt tcagagtgct ccaaaaaata tgttaattat tttattttgt   2340

ttaataaaga acattctcaa aacgtaaata ggtatctaga gaagtgagta ctcaacattt   2400

ggtatattgt tttgagtaat ggatgtttgt tttttgtgta atttgtgaat aaatagtttt   2460

tttctgcatt ttgaagattt tcctattatt ttatgttgtt agcttttgaa aaattagatt   2520

gatctactta gtgtctttct tatatgaact taatatattt aaagtacctt gcatggtgcc   2580

tcacacatga agtaatgcca gctatttcag taaatgctag ctatttctat gaagaacttg   2640

agttagtttg gagatattta acctcaattt cctctgattt taaaaaagga gaactttttt   2700

tgtaatcctt tccttatctg aaagtaagaa gtctctgatt ccagtattat aggagagata   2760

gtgggatttt tcttgacagg gtctatagct caagtcccaa agaggcaaga ctcaggatgg   2820

aatgcatgtg gccactaggc cctgttataa gaacctagtg tttcctctgt actggcatgg   2880

taggccaagt tagtctcttt cttacccaga tataagacat aaaatagttt agacataaga   2940

cagaggagaa aaagaaacag taagttatgg agaaggaagg cagctcattt ctgcaggccc   3000

ctcaaaatgc ttattttagc tcatactctt ctatgcgtga agagaaaaat gcacccatta   3060

ttttacaagg atgtgaatac tgatatacaa acatagacta agcttgttaa ttttaataac   3120

aaatctttat gaatctgaag agaattgatg ttcatgataa tgatatagat gtttaatata   3180

ctttctgaaa taacactgtt tactgttcaa gttatattga ctataattta cattattctt   3240

gtttgagaat tgtatggcat agacactcat tagtcagagt gtctagacat ccagaccatg   3300

cctgataaca caagaatcat atatcattct ctagaaaaca ggctgtttgg ttatagagta   3360

tttatcttaa atatattaac agacactaca taaacattga aaagccatgc aagttatagc   3420

tcacaggagc cagatctact gcaactgggg cctacataca aaattttatg gcagtggttt   3480

cagtatgaca atcttttgaa ttgatgccgt atggtaaaac tataaagatt ttttaaaagc   3540

tctgtctcag ctagaatttt taagattata actgaacagt atagcccttt tagttgtttg   3600

aaaattacat aatgattcaa aagcttgttt cactgccttt cccagcacta agaaaattaa   3660

caatcatttc ttttaatttc cttgaatcag agccattcta aagtgactct ggaccagcaa   3720

ttctgagcta tgatttcatg atacatgtat taatatctaa atgagttgtg agttgacata   3780

agaaccatag ttccataata attatcttca aatcaatgga tatcttaaat gtgttttttt   3840

cttccttaga gattattatt aaactgatgt atttgataat aaagaatttt aggactgaga   3900

aagttaagtt tttcttacca ataataagat attgaaatat ataaattata aaacagaaat   3960

aaaatgaaat aaaggaggtt atccctaaag tcatttacct tagtcacttg caattaaata   4020

tggttacttc ggaagaagaa gtgtggccct aaagctactg taacatgaat catgccctaa   4080

tgtgcactat atatgaacta ctttggtcag aaggcagcgg cgggtaagga tggcttcctc   4140

tcacagtgct tcttaggcta tccatttacc aaggaattct aatctctttc tctcacttca   4200

ccaggaaagg agggagttta agatatagaa ctgggcatgc tagcctcttt tttccctttt   4260

gtggatttgt cataactgca gagaaccgat gttgtggtct cttgccagct acattgtgaa   4320

ccttgcagtg aaagttcttt gcctctgcaa agggagattt gtgcttgtgc agaactgccc   4380

atgccttagt aagcaggtct gtctaattct aagttcaata tctggtggct attgttggca   4440

taaacttaaa gtacatcctc taacctagcc tttttcagca gtaaacttaa aatattgaat   4500

ctccatctgt ctgtgtctca agtggttcag aggtcaggag aggagaggga cattatttta   4560

tgactccctc aaactttaac aaagactagt gcagattata tttcgaagta agcatgagat   4620

atattaaaaa ccacatgtgg gaattctttc ctaattttag aggttttttt taaataatgg   4680

aaattctatt gaaattgagt agtgttaatt acaaggcaac aggtaaacat ttgttcagga   4740

tatttaaaag gtctgctgag ttggaattgt gacagaccac attgttgact ctagattgaa   4800

ttggaaggga agaatgtgaa atgaattagg atatcctctg ttcacctcta ttaactttct   4860

taaatgagta taacttagaa ataataaaat gcaagtattt taacgttata gttgggagag   4920

ttttgacaaa tgtaaacacc cacttcacca ccactaccat cctgatatag tgtgtgtcca   4980

tcacccaaaa agttctctaa agcccttttg cagttggttc ccctccacct gaacagccat   5040

ccctagtcaa ctacttttct gctttctgtg gctatacgtt agatttgact tcagaattct   5100

agagtttgaa ataaataggc catataatat gcactctttt tgtgtctgac tttttttttg   5160

cttaacatga tgcttttgaa acccatccat gttgagattc atccatgtta tcatgtgtat   5220

caataataag ttccttttta ttgctgaata gtattctagt atatagatat accacaattt   5280

gtttagctgt tcacctattg atggacattt aggttgtttc aagttttgat ctattatgaa   5340

taaagctgct atatatataa atcac                                         5365


<210>  2055
<211>  218
<212>  PRT
<213>  Homo sapiens

<400>  2055


Met Ala Ser Phe Gly Trp Lys Arg Lys Ile Gly Glu Lys Val Ser Lys 
1               5                   10                  15      


Val Thr Ser Gln Gln Phe Glu Ala Glu Ala Ala Asp Glu Lys Asp Val 
            20                  25                  30          


Val Asp Asn Asp Glu Gly Asn Trp Leu His Ala Ile Lys Arg Arg Lys 
        35                  40                  45              


Glu Ile Leu Leu Glu Gly Cys Ala Glu Lys Ser Lys Gln Leu Lys Asp 
    50                  55                  60                  


Glu Gly Ala Ser Leu Ala Glu Asn Lys Arg Tyr Arg Glu Ala Ile Gln 
65                  70                  75                  80  


Lys Trp Asp Glu Ala Leu Gln Leu Thr Pro Asn Asp Ala Thr Leu Tyr 
                85                  90                  95      


Glu Met Lys Ser Gln Ala Ile Arg Ser Phe Gln Val Ala Leu His Ile 
            100                 105                 110         


Tyr Pro Met Asn Pro Glu Ile Trp Lys Glu Asp Leu Ser Trp Ala Arg 
        115                 120                 125             


Thr Leu Gln Glu Gln Gln Lys Val Ala Gln Arg Ile Lys Lys Ser Glu 
    130                 135                 140                 


Ala Pro Ala Glu Val Thr His Phe Ser Pro Lys Ser Ile Pro Asp Tyr 
145                 150                 155                 160 


Asp Phe Glu Ser Asp Glu Ile Val Ala Val Cys Ala Ala Ile Ala Glu 
                165                 170                 175     


Lys Glu Lys Thr Val Ser Ala Asn Lys Thr Met Val Ile Val Ser Ala 
            180                 185                 190         


Ser Gly Ala Ile Glu Thr Val Thr Glu Lys Glu Asp Gly Ala Thr Pro 
        195                 200                 205             


Pro Asp Gly Ser Val Phe Ile Lys Ala Arg 
    210                 215             

<210>  2056
<211>  5283
<212>  DNA
<213>  Homo sapiens

<400>  2056
gggatttgtg gtcccggaga agagattggc ggaggggaaa gactgagtcg tctttccttt     60

gcccgcttct gtggactgtt cgaacgccca ggggtgggcc aaacccgttt cttaggaaac    120

caggaatcca gggaaggcag aatggcttcc tttgggtgga agaggaaaat tggtgagaag    180

gtctcaaagg tcacttccca gcagtttgaa gctgaagctg ctgatgagaa ggatgtagtt    240

gacaacgatg aagggaactg gcttcatgcc attaaacgta ggaaagaaat tcttcttgaa    300

ggctgtgctg agaaaagtaa acagctgaag gatgaaggag ccagtttggc tgaaaataaa    360

aggcaattcg aagttttcaa gtagcccttc acatctatcc aatgaaccct gaaatatgga    420

aagaagacct ctcttgggca agaacgctcc aggagcagca gaaggtagca cagaggatta    480

aaaaaagtga agcaccagct gaagtaacac acttttcacc aaagtcaatt ccagactatg    540

actttgaaag tgatgagatt gttgctgttt gtgcagctat tgctgagaaa gagaagacag    600

tttcagcaaa taaaacaatg gttattgtgt ctgcttctgg ggccatagag actgtaactg    660

aaaaggagga tggtgctaca ccaccagatg gctctgtttt tatcaaagcc cgatgaagca    720

gtatgcatag gattatttga atctgtcttt ttgattgcct cttgaagttt tgacatagag    780

acatttactc tggagataga taggagaacg cctggttgta aaatatgttt ttcagatgag    840

gcatataaaa actaaaatgg caggattatt gtatagtgtt tggaatatgc tttgataagt    900

tatgatttat atttctcaag gttaaaattc tgagtaaaat ggtctttgat taataaactt    960

agtttaatct gaatatgtaa atgaatacat tttaaagaca aaacttgaaa aatgtattct   1020

tgaatagtga ataatttgat caatgttact gaaatgctgt ctcaactttt gttttatgat   1080

aaaggaagtg tgtgatttcc ctccctctga gaaatatact gcgcttaata tttgctgtct   1140

ttttcttgct tcattagagt aagtctgtca gaaagcttga atatttttga cattcatttt   1200

gattcaaagt tgtcatttgg ttatatgtgg aatctttgaa agtttggctg aaaatgcaca   1260

caaatgtgta cattctgaac attttctgaa gtttctctta attctgattt gtgtttctgt   1320

tttgactttg aagttgtaac aatgatagtt gtctccttca gtatttggta aaagtgtaaa   1380

gtattgataa atatgagaat gatggtttta ttttttaatt gttacagtaa gtaatcctta   1440

ccacaaatga gtcattttta aaatatgcat ttttaaatga atggctttta cagataggtt   1500

aatgacaatt gtactgctat attatcccag tcaaaaccaa tactttcttt tctttatttt   1560

acaaagcttt aaaaaccctg gaaacaactt acttcttgct tgtgtctttc catttgatga   1620

ctgggaatta cttttctaga taactttttt tgaaactact cagtgaaatg aaaaataatt   1680

acaattttaa atagctaatt atatctttct aaaaataaaa aagtagggct gttattagag   1740

tgccaatgaa taaataactt aagcacaaaa tacatagaaa ttggaatgtg atttatagta   1800

caatctcatg agtatgaaaa ggctatatta aaaaaaattt tattgaaagt ccacagtcat   1860

attcacaaac caatactgtc attgctaatc tgaactatta tttttatact atatattgta   1920

gtacaataat atagaactgt tgggttctgt tacttctgac actcaggaag atactattgg   1980

tgtattaatt ttatctttgt tagagatgaa agtagcccac tttatgttaa agatcttact   2040

actgttggag cttataagta atgatctaca ttttttatga agatggtttt taaaactttt   2100

gttttattgg aatgcatatc tcttttcagg gttggagaaa ttagcacttg ccttgaaaag   2160

aatattcttt ccttaagtta tatcatcaga aaattagctc tggttagaga ggttagtttc   2220

agagtgctcc aaaaaatatg ttaattattt tattttgttt aataaagaac attctcaaaa   2280

cgtaaatagg tatctagaga agtgagtact caacatttgg tatattgttt tgagtaatgg   2340

atgtttgttt tttgtgtaat ttgtgaataa atagtttttt tctgcatttt gaagattttc   2400

ctattatttt atgttgttag cttttgaaaa attagattga tctacttagt gtctttctta   2460

tatgaactta atatatttaa agtaccttgc atggtgcctc acacatgaag taatgccagc   2520

tatttcagta aatgctagct atttctatga agaacttgag ttagtttgga gatatttaac   2580

ctcaatttcc tctgatttta aaaaaggaga actttttttg taatcctttc cttatctgaa   2640

agtaagaagt ctctgattcc agtattatag gagagatagt gggatttttc ttgacagggt   2700

ctatagctca agtcccaaag aggcaagact caggatggaa tgcatgtggc cactaggccc   2760

tgttataaga acctagtgtt tcctctgtac tggcatggta ggccaagtta gtctctttct   2820

tacccagata taagacataa aatagtttag acataagaca gaggagaaaa agaaacagta   2880

agttatggag aaggaaggca gctcatttct gcaggcccct caaaatgctt attttagctc   2940

atactcttct atgcgtgaag agaaaaatgc acccattatt ttacaaggat gtgaatactg   3000

atatacaaac atagactaag cttgttaatt ttaataacaa atctttatga atctgaagag   3060

aattgatgtt catgataatg atatagatgt ttaatatact ttctgaaata acactgttta   3120

ctgttcaagt tatattgact ataatttaca ttattcttgt ttgagaattg tatggcatag   3180

acactcatta gtcagagtgt ctagacatcc agaccatgcc tgataacaca agaatcatat   3240

atcattctct agaaaacagg ctgtttggtt atagagtatt tatcttaaat atattaacag   3300

acactacata aacattgaaa agccatgcaa gttatagctc acaggagcca gatctactgc   3360

aactggggcc tacatacaaa attttatggc agtggtttca gtatgacaat cttttgaatt   3420

gatgccgtat ggtaaaacta taaagatttt ttaaaagctc tgtctcagct agaattttta   3480

agattataac tgaacagtat agccctttta gttgtttgaa aattacataa tgattcaaaa   3540

gcttgtttca ctgcctttcc cagcactaag aaaattaaca atcatttctt ttaatttcct   3600

tgaatcagag ccattctaaa gtgactctgg accagcaatt ctgagctatg atttcatgat   3660

acatgtatta atatctaaat gagttgtgag ttgacataag aaccatagtt ccataataat   3720

tatcttcaaa tcaatggata tcttaaatgt gtttttttct tccttagaga ttattattaa   3780

actgatgtat ttgataataa agaattttag gactgagaaa gttaagtttt tcttaccaat   3840

aataagatat tgaaatatat aaattataaa acagaaataa aatgaaataa aggaggttat   3900

ccctaaagtc atttacctta gtcacttgca attaaatatg gttacttcgg aagaagaagt   3960

gtggccctaa agctactgta acatgaatca tgccctaatg tgcactatat atgaactact   4020

ttggtcagaa ggcagcggcg ggtaaggatg gcttcctctc acagtgcttc ttaggctatc   4080

catttaccaa ggaattctaa tctctttctc tcacttcacc aggaaaggag ggagtttaag   4140

atatagaact gggcatgcta gcctcttttt tcccttttgt ggatttgtca taactgcaga   4200

gaaccgatgt tgtggtctct tgccagctac attgtgaacc ttgcagtgaa agttctttgc   4260

ctctgcaaag ggagatttgt gcttgtgcag aactgcccat gccttagtaa gcaggtctgt   4320

ctaattctaa gttcaatatc tggtggctat tgttggcata aacttaaagt acatcctcta   4380

acctagcctt tttcagcagt aaacttaaaa tattgaatct ccatctgtct gtgtctcaag   4440

tggttcagag gtcaggagag gagagggaca ttattttatg actccctcaa actttaacaa   4500

agactagtgc agattatatt tcgaagtaag catgagatat attaaaaacc acatgtggga   4560

attctttcct aattttagag gtttttttta aataatggaa attctattga aattgagtag   4620

tgttaattac aaggcaacag gtaaacattt gttcaggata tttaaaaggt ctgctgagtt   4680

ggaattgtga cagaccacat tgttgactct agattgaatt ggaagggaag aatgtgaaat   4740

gaattaggat atcctctgtt cacctctatt aactttctta aatgagtata acttagaaat   4800

aataaaatgc aagtatttta acgttatagt tgggagagtt ttgacaaatg taaacaccca   4860

cttcaccacc actaccatcc tgatatagtg tgtgtccatc acccaaaaag ttctctaaag   4920

cccttttgca gttggttccc ctccacctga acagccatcc ctagtcaact acttttctgc   4980

tttctgtggc tatacgttag atttgacttc agaattctag agtttgaaat aaataggcca   5040

tataatatgc actctttttg tgtctgactt tttttttgct taacatgatg cttttgaaac   5100

ccatccatgt tgagattcat ccatgttatc atgtgtatca ataataagtt cctttttatt   5160

gctgaatagt attctagtat atagatatac cacaatttgt ttagctgttc acctattgat   5220

ggacatttag gttgtttcaa gttttgatct attatgaata aagctgctat atatataaat   5280

cac                                                                 5283


<210>  2057
<211>  80
<212>  PRT
<213>  Homo sapiens

<400>  2057


Met Ala Ser Phe Gly Trp Lys Arg Lys Ile Gly Glu Lys Val Ser Lys 
1               5                   10                  15      


Val Thr Ser Gln Gln Phe Glu Ala Glu Ala Ala Asp Glu Lys Asp Val 
            20                  25                  30          


Val Asp Asn Asp Glu Gly Asn Trp Leu His Ala Ile Lys Arg Arg Lys 
        35                  40                  45              


Glu Ile Leu Leu Glu Gly Cys Ala Glu Lys Ser Lys Gln Leu Lys Asp 
    50                  55                  60                  


Glu Gly Ala Ser Leu Ala Glu Asn Lys Arg Gln Phe Glu Val Phe Lys 
65                  70                  75                  80  

<210>  2058
<211>  5990
<212>  DNA
<213>  Homo sapiens

<400>  2058
tttattacat gtgctcgttt attttcaaga catgatgcac agctacgttc tggctgtaat     60

tctgccttct gggtccaact cacttgtaac tttaacgtga agcctgcagt tcagcctcga    120

gcctccctga ctagcctccc cgcccggccg cctcgagccc tttataaccg aattttgcct    180

ctctgttctc tgcgtctggc cgacctcatc agctaggcta taaacccctt cggggaagga    240

gcatatccta atcctttgaa tcccgtaaaa taagttttcc cctcaccttg ttccccactg    300

acgggacgcg aggctgcgcg gtaccgcggg ggcggctcct ctcggtgcgc tcttcagccc    360

gcgcagcctc attttcccgc gctcgtgcgc tgcggtcact cagggctgct gctagagggc    420

gcgcccagcc gcgtggccct gactactaca aatcccagaa ggtcatgcag tgggggcggc    480

cgcggtgact tctgggattt gtggtcccgg agaagagatt ggcggagggg aaagactgag    540

tcgtctttcc tttgcccgct tctgtggact gttcgaacgc ccaggggtgg gccaaacccg    600

tttcttagga aaccaggaat ccagggaagg cagaatggct tcctttgggt ggaagaggaa    660

aattggtgag aaggtctcaa aggtcacttc ccagcagttt gaagctgaag ctgctgatga    720

gaaggatgta gttgacaacg atgaagggaa ctggcttcat gccattaaac gtaggaaaga    780

aattcttctt gaaggctgtg ctgagaaaag taaacagctg aaggatgaag gagccagttt    840

ggctgaaaat aaaagatatc gggaggcaat tcagaagtgg gatgaagcac tacagttaac    900

tccaaatgat gctaccctat acgagatgaa atcacaggtg ctaatgtctc ttcatgaaat    960

gttcccagca gtacatgcag cagaaatggc cgtccagcaa aatccacatt catgggagtc   1020

ttggcagact ttgggacgtg ctcaacttgg tttaggagag ataatcctgg caattcgaag   1080

ttttcaagta gcccttcaca tctatccaat gaaccctgaa atatggaaag aagacctctc   1140

ttgggcaaga acgctccagg agcagcagaa ggtagcacag aggattaaaa aaagtgaagc   1200

accagctgaa gtaacacact tttcaccaaa gtcaattcca gactatgact ttgaaagtga   1260

tgagattgtt gctgtttgtg cagctattgc tgagaaagag aagacagttt cagcaaataa   1320

aacaatggtt attgtgtctg cttctggggc catagagact gtaactgaaa aggaggatgg   1380

tgctacacca ccagatggct ctgtttttat caaagcccga tgaagcagta tgcataggat   1440

tatttgaatc tgtctttttg attgcctctt gaagttttga catagagaca tttactctgg   1500

agatagatag gagaacgcct ggttgtaaaa tatgtttttc agatgaggca tataaaaact   1560

aaaatggcag gattattgta tagtgtttgg aatatgcttt gataagttat gatttatatt   1620

tctcaaggtt aaaattctga gtaaaatggt ctttgattaa taaacttagt ttaatctgaa   1680

tatgtaaatg aatacatttt aaagacaaaa cttgaaaaat gtattcttga atagtgaata   1740

atttgatcaa tgttactgaa atgctgtctc aacttttgtt ttatgataaa ggaagtgtgt   1800

gatttccctc cctctgagaa atatactgcg cttaatattt gctgtctttt tcttgcttca   1860

ttagagtaag tctgtcagaa agcttgaata tttttgacat tcattttgat tcaaagttgt   1920

catttggtta tatgtggaat ctttgaaagt ttggctgaaa atgcacacaa atgtgtacat   1980

tctgaacatt ttctgaagtt tctcttaatt ctgatttgtg tttctgtttt gactttgaag   2040

ttgtaacaat gatagttgtc tccttcagta tttggtaaaa gtgtaaagta ttgataaata   2100

tgagaatgat ggttttattt tttaattgtt acagtaagta atccttacca caaatgagtc   2160

atttttaaaa tatgcatttt taaatgaatg gcttttacag ataggttaat gacaattgta   2220

ctgctatatt atcccagtca aaaccaatac tttcttttct ttattttaca aagctttaaa   2280

aaccctggaa acaacttact tcttgcttgt gtctttccat ttgatgactg ggaattactt   2340

ttctagataa ctttttttga aactactcag tgaaatgaaa aataattaca attttaaata   2400

gctaattata tctttctaaa aataaaaaag tagggctgtt attagagtgc caatgaataa   2460

ataacttaag cacaaaatac atagaaattg gaatgtgatt tatagtacaa tctcatgagt   2520

atgaaaaggc tatattaaaa aaaattttat tgaaagtcca cagtcatatt cacaaaccaa   2580

tactgtcatt gctaatctga actattattt ttatactata tattgtagta caataatata   2640

gaactgttgg gttctgttac ttctgacact caggaagata ctattggtgt attaatttta   2700

tctttgttag agatgaaagt agcccacttt atgttaaaga tcttactact gttggagctt   2760

ataagtaatg atctacattt tttatgaaga tggtttttaa aacttttgtt ttattggaat   2820

gcatatctct tttcagggtt ggagaaatta gcacttgcct tgaaaagaat attctttcct   2880

taagttatat catcagaaaa ttagctctgg ttagagaggt tagtttcaga gtgctccaaa   2940

aaatatgtta attattttat tttgtttaat aaagaacatt ctcaaaacgt aaataggtat   3000

ctagagaagt gagtactcaa catttggtat attgttttga gtaatggatg tttgtttttt   3060

gtgtaatttg tgaataaata gtttttttct gcattttgaa gattttccta ttattttatg   3120

ttgttagctt ttgaaaaatt agattgatct acttagtgtc tttcttatat gaacttaata   3180

tatttaaagt accttgcatg gtgcctcaca catgaagtaa tgccagctat ttcagtaaat   3240

gctagctatt tctatgaaga acttgagtta gtttggagat atttaacctc aatttcctct   3300

gattttaaaa aaggagaact ttttttgtaa tcctttcctt atctgaaagt aagaagtctc   3360

tgattccagt attataggag agatagtggg atttttcttg acagggtcta tagctcaagt   3420

cccaaagagg caagactcag gatggaatgc atgtggccac taggccctgt tataagaacc   3480

tagtgtttcc tctgtactgg catggtaggc caagttagtc tctttcttac ccagatataa   3540

gacataaaat agtttagaca taagacagag gagaaaaaga aacagtaagt tatggagaag   3600

gaaggcagct catttctgca ggcccctcaa aatgcttatt ttagctcata ctcttctatg   3660

cgtgaagaga aaaatgcacc cattatttta caaggatgtg aatactgata tacaaacata   3720

gactaagctt gttaatttta ataacaaatc tttatgaatc tgaagagaat tgatgttcat   3780

gataatgata tagatgttta atatactttc tgaaataaca ctgtttactg ttcaagttat   3840

attgactata atttacatta ttcttgtttg agaattgtat ggcatagaca ctcattagtc   3900

agagtgtcta gacatccaga ccatgcctga taacacaaga atcatatatc attctctaga   3960

aaacaggctg tttggttata gagtatttat cttaaatata ttaacagaca ctacataaac   4020

attgaaaagc catgcaagtt atagctcaca ggagccagat ctactgcaac tggggcctac   4080

atacaaaatt ttatggcagt ggtttcagta tgacaatctt ttgaattgat gccgtatggt   4140

aaaactataa agatttttta aaagctctgt ctcagctaga atttttaaga ttataactga   4200

acagtatagc ccttttagtt gtttgaaaat tacataatga ttcaaaagct tgtttcactg   4260

cctttcccag cactaagaaa attaacaatc atttctttta atttccttga atcagagcca   4320

ttctaaagtg actctggacc agcaattctg agctatgatt tcatgataca tgtattaata   4380

tctaaatgag ttgtgagttg acataagaac catagttcca taataattat cttcaaatca   4440

atggatatct taaatgtgtt tttttcttcc ttagagatta ttattaaact gatgtatttg   4500

ataataaaga attttaggac tgagaaagtt aagtttttct taccaataat aagatattga   4560

aatatataaa ttataaaaca gaaataaaat gaaataaagg aggttatccc taaagtcatt   4620

taccttagtc acttgcaatt aaatatggtt acttcggaag aagaagtgtg gccctaaagc   4680

tactgtaaca tgaatcatgc cctaatgtgc actatatatg aactactttg gtcagaaggc   4740

agcggcgggt aaggatggct tcctctcaca gtgcttctta ggctatccat ttaccaagga   4800

attctaatct ctttctctca cttcaccagg aaaggaggga gtttaagata tagaactggg   4860

catgctagcc tcttttttcc cttttgtgga tttgtcataa ctgcagagaa ccgatgttgt   4920

ggtctcttgc cagctacatt gtgaaccttg cagtgaaagt tctttgcctc tgcaaaggga   4980

gatttgtgct tgtgcagaac tgcccatgcc ttagtaagca ggtctgtcta attctaagtt   5040

caatatctgg tggctattgt tggcataaac ttaaagtaca tcctctaacc tagccttttt   5100

cagcagtaaa cttaaaatat tgaatctcca tctgtctgtg tctcaagtgg ttcagaggtc   5160

aggagaggag agggacatta ttttatgact ccctcaaact ttaacaaaga ctagtgcaga   5220

ttatatttcg aagtaagcat gagatatatt aaaaaccaca tgtgggaatt ctttcctaat   5280

tttagaggtt ttttttaaat aatggaaatt ctattgaaat tgagtagtgt taattacaag   5340

gcaacaggta aacatttgtt caggatattt aaaaggtctg ctgagttgga attgtgacag   5400

accacattgt tgactctaga ttgaattgga agggaagaat gtgaaatgaa ttaggatatc   5460

ctctgttcac ctctattaac tttcttaaat gagtataact tagaaataat aaaatgcaag   5520

tattttaacg ttatagttgg gagagttttg acaaatgtaa acacccactt caccaccact   5580

accatcctga tatagtgtgt gtccatcacc caaaaagttc tctaaagccc ttttgcagtt   5640

ggttcccctc cacctgaaca gccatcccta gtcaactact tttctgcttt ctgtggctat   5700

acgttagatt tgacttcaga attctagagt ttgaaataaa taggccatat aatatgcact   5760

ctttttgtgt ctgacttttt ttttgcttaa catgatgctt ttgaaaccca tccatgttga   5820

gattcatcca tgttatcatg tgtatcaata ataagttcct ttttattgct gaatagtatt   5880

ctagtatata gatataccac aatttgttta gctgttcacc tattgatgga catttaggtt   5940

gtttcaagtt ttgatctatt atgaataaag ctgctatata tataaatcac              5990


<210>  2059
<211>  262
<212>  PRT
<213>  Homo sapiens

<400>  2059


Met Ala Ser Phe Gly Trp Lys Arg Lys Ile Gly Glu Lys Val Ser Lys 
1               5                   10                  15      


Val Thr Ser Gln Gln Phe Glu Ala Glu Ala Ala Asp Glu Lys Asp Val 
            20                  25                  30          


Val Asp Asn Asp Glu Gly Asn Trp Leu His Ala Ile Lys Arg Arg Lys 
        35                  40                  45              


Glu Ile Leu Leu Glu Gly Cys Ala Glu Lys Ser Lys Gln Leu Lys Asp 
    50                  55                  60                  


Glu Gly Ala Ser Leu Ala Glu Asn Lys Arg Tyr Arg Glu Ala Ile Gln 
65                  70                  75                  80  


Lys Trp Asp Glu Ala Leu Gln Leu Thr Pro Asn Asp Ala Thr Leu Tyr 
                85                  90                  95      


Glu Met Lys Ser Gln Val Leu Met Ser Leu His Glu Met Phe Pro Ala 
            100                 105                 110         


Val His Ala Ala Glu Met Ala Val Gln Gln Asn Pro His Ser Trp Glu 
        115                 120                 125             


Ser Trp Gln Thr Leu Gly Arg Ala Gln Leu Gly Leu Gly Glu Ile Ile 
    130                 135                 140                 


Leu Ala Ile Arg Ser Phe Gln Val Ala Leu His Ile Tyr Pro Met Asn 
145                 150                 155                 160 


Pro Glu Ile Trp Lys Glu Asp Leu Ser Trp Ala Arg Thr Leu Gln Glu 
                165                 170                 175     


Gln Gln Lys Val Ala Gln Arg Ile Lys Lys Ser Glu Ala Pro Ala Glu 
            180                 185                 190         


Val Thr His Phe Ser Pro Lys Ser Ile Pro Asp Tyr Asp Phe Glu Ser 
        195                 200                 205             


Asp Glu Ile Val Ala Val Cys Ala Ala Ile Ala Glu Lys Glu Lys Thr 
    210                 215                 220                 


Val Ser Ala Asn Lys Thr Met Val Ile Val Ser Ala Ser Gly Ala Ile 
225                 230                 235                 240 


Glu Thr Val Thr Glu Lys Glu Asp Gly Ala Thr Pro Pro Asp Gly Ser 
                245                 250                 255     


Val Phe Ile Lys Ala Arg 
            260         

<210>  2060
<211>  3092
<212>  DNA
<213>  Homo sapiens

<400>  2060
tttattacat gtgctcgttt attttcaaga catgatgcac agctacgttc tggctgtaat     60

tctgccttct gggtccaact cacttgtaac tttaacgtga agcctgcagt tcagcctcga    120

gcctccctga ctagcctccc cgcccggccg cctcgagccc tttataaccg aattttgcct    180

ctctgttctc tgcgtctggc cgacctcatc agctaggcta taaacccctt cggggaagga    240

gcatatccta atcctttgaa tcccgtaaaa taagttttcc cctcaccttg ttccccactg    300

acgggacgcg aggctgcgcg gtaccgcggg ggcggctcct ctcggtgcgc tcttcagccc    360

gcgcagcctc attttcccgc gctcgtgcgc tgcggtcact cagggctgct gctagagggc    420

gcgcccagcc gcgtggccct gactactaca aatcccagaa ggtcatgcag tgggggcggc    480

cgcggtgact tctgggattt gtggtcccgg agaagagatt ggcggagggg aaagactgag    540

tcgtctttcc tttgcccgct tctgtggact gttcgaacgc ccaggggtgg gccaaacccg    600

tttcttagga aaccaggaat ccagggaagg cagaatggct tcctttgggt ggaagaggaa    660

aattggtgag aaggtctcaa aggtcacttc ccagcagttt gaagctgaag ctgctgatga    720

gaaggatgta gttgacaacg atgaagggaa ctggcttcat gccattaaac gtaggaaaga    780

aattcttctt gaaggctgtg ctgagaaaag taaacagctg aaggatgaag gagccagttt    840

ggctgaaaat aaaagatatc gggaggcaat tcagaagtgg gatgaagcac tacagttaac    900

tccaaatgat gctaccctat acgagatgaa atcacaggtg ctaatgtctc ttcatgaaat    960

gttcccagca gtacatgcag cagaaatggc cgtccagcaa aatccacatt catgggagtc   1020

ttggcagact ttgggacgtg ctcaacttgg tttaggagag ataatcctgg caattcgaag   1080

ttttcaagta gcccttcaca tctatccaat gaaccctgaa atatggaaag aagacctctc   1140

ttgggcaaga acgctccagg agcagcagaa ggtagcacag aggattaaaa aaagtgaagc   1200

accagctgaa gtaacacact tttcaccaaa gtcaattcca gactatgact ttgaaagtga   1260

tgagattgtt gctgtttgtg cagctattgc tgagaaagag aagacagttt cagcaaataa   1320

aacaatggtt attgtgtctg cttctggggc catagagact gtaactgaaa aggaggatgg   1380

tgctacacca ccagatggct ctgtttttat caaagcccga tgaagcagta tgcataggat   1440

tatttgaatc tgtctttttg attgcctctt gaagttttga catagagaca tttactctgg   1500

agatagatag gagaacgcct ggttgtaaaa tatgtttttc agatgaggca tataaaaact   1560

aaaatggcag gattattgta tagtgtttgg aatatgcttt gataagttat gatttatatt   1620

tctcaaggtt aaaattctga gtaaaatggt ctttgattaa taaacttagt ttaatctgaa   1680

tatgtaaatg aatacatttt aaagacaaaa cttgaaaaat gtattcttga atagtgaata   1740

atttgatcaa tgttactgaa atgctgtctc aacttttgtt ttatgataaa ggaagtgtgt   1800

gatttccctc cctctgagaa atatactgcg cttaatattt gctgtctttt tcttgcttca   1860

ttagagtaag tctgtcagaa agcttgaata tttttgacat tcattttgat tcaaagttgt   1920

catttggtta tatgtggaat ctttgaaagt ttggctgaaa atgcacacaa atgtgtacat   1980

tctgaacatt ttctgaagtt tctcttaatt ctgatttgtg tttctgtttt gactttgaag   2040

ttgtaacaat gatagttgtc tccttcagta tttggtaaaa gtgtaaagta ttgataaata   2100

tgagaatgat ggttttattt tttaattgtt acagtaagta atccttacca caaatgagtc   2160

atttttaaaa tatgcatttt taaatgaatg gcttttacag ataggttaat gacaattgta   2220

ctgctatatt atcccagtca aaaccaatac tttcttttct ttattttaca aagctttaaa   2280

aaccctggaa acaacttact tcttgcttgt gtctttccat ttgatgactg ggaattactt   2340

ttctagataa ctttttttga aactactcag tgaaatgaaa aataattaca attttaaata   2400

gctaattata tctttctaaa aataaaaaag tagggctgtt attagagtgc caatgaataa   2460

ataacttaag cacaaaatac atagaaattg gaatgtgatt tatagtacaa tctcatgagt   2520

atgaaaaggc tatattaaaa aaaattttat tgaaagtcca cagtcatatt cacaaaccaa   2580

tactgtcatt gctaatctga actattattt ttatactata tattgtagta caataatata   2640

gaactgttgg gttctgttac ttctgacact caggaagata ctattggtgt attaatttta   2700

tctttgttag agatgaaagt agcccacttt atgttaaaga tcttactact gttggagctt   2760

ataagtaatg atctacattt tttatgaaga tggtttttaa aacttttgtt ttattggaat   2820

gcatatctct tttcagggtt ggagaaatta gcacttgcct tgaaaagaat attctttcct   2880

taagttatat catcagaaaa ttagctctgg ttagagaggt tagtttcaga gtgctccaaa   2940

aaatatgtta attattttat tttgtttaat aaagaacatt ctcaaaacgt aaataggtat   3000

ctagagaagt gagtactcaa catttggtat attgttttga gtaatggatg tttgtttttt   3060

gtgtaatttg tgaataaata gtttttttct gc                                 3092


<210>  2061
<211>  262
<212>  PRT
<213>  Homo sapiens

<400>  2061


Met Ala Ser Phe Gly Trp Lys Arg Lys Ile Gly Glu Lys Val Ser Lys 
1               5                   10                  15      


Val Thr Ser Gln Gln Phe Glu Ala Glu Ala Ala Asp Glu Lys Asp Val 
            20                  25                  30          


Val Asp Asn Asp Glu Gly Asn Trp Leu His Ala Ile Lys Arg Arg Lys 
        35                  40                  45              


Glu Ile Leu Leu Glu Gly Cys Ala Glu Lys Ser Lys Gln Leu Lys Asp 
    50                  55                  60                  


Glu Gly Ala Ser Leu Ala Glu Asn Lys Arg Tyr Arg Glu Ala Ile Gln 
65                  70                  75                  80  


Lys Trp Asp Glu Ala Leu Gln Leu Thr Pro Asn Asp Ala Thr Leu Tyr 
                85                  90                  95      


Glu Met Lys Ser Gln Val Leu Met Ser Leu His Glu Met Phe Pro Ala 
            100                 105                 110         


Val His Ala Ala Glu Met Ala Val Gln Gln Asn Pro His Ser Trp Glu 
        115                 120                 125             


Ser Trp Gln Thr Leu Gly Arg Ala Gln Leu Gly Leu Gly Glu Ile Ile 
    130                 135                 140                 


Leu Ala Ile Arg Ser Phe Gln Val Ala Leu His Ile Tyr Pro Met Asn 
145                 150                 155                 160 


Pro Glu Ile Trp Lys Glu Asp Leu Ser Trp Ala Arg Thr Leu Gln Glu 
                165                 170                 175     


Gln Gln Lys Val Ala Gln Arg Ile Lys Lys Ser Glu Ala Pro Ala Glu 
            180                 185                 190         


Val Thr His Phe Ser Pro Lys Ser Ile Pro Asp Tyr Asp Phe Glu Ser 
        195                 200                 205             


Asp Glu Ile Val Ala Val Cys Ala Ala Ile Ala Glu Lys Glu Lys Thr 
    210                 215                 220                 


Val Ser Ala Asn Lys Thr Met Val Ile Val Ser Ala Ser Gly Ala Ile 
225                 230                 235                 240 


Glu Thr Val Thr Glu Lys Glu Asp Gly Ala Thr Pro Pro Asp Gly Ser 
                245                 250                 255     


Val Phe Ile Lys Ala Arg 
            260         

<210>  2062
<211>  560
<212>  DNA
<213>  Homo sapiens

<400>  2062
agaaaccccg tctctagtaa aaatacaaaa attagccggt gtgggtggtg catgagtgta     60

atcccagcta ttcgggaggc tgaggcagga gaatcactta acccgggagg cggaggttac    120

ggtgagccga ggtcgtgcca tcgtactcca gcctgggcaa cgagagtgag actccatctc    180

aaaaaaaaaa aaagatcaag ttagaatttt aaagctgttt ctttgtaatt ttccagaatg    240

gcttcctttg ggtggaagag gaaaattggt gagaaggtct caaaggtcac ttcccagcag    300

tttgaagctg aagctgctga tgagaaggat gtagttgaca acgatgaagg gaactggctt    360

catgccatta aacgtaggaa agaaattctt cttgaaggct gtgctgagaa aagtaaacag    420

ctgaaggatg aaggagccag tttggcttgg atagtcgtca agtcagagtt gtccctcatt    480

ggagtcccat gcccctcggg aatgagctgg tcttcttatt tctgctactt ccagttaatg    540

tggagaaaag ccatgagata                                                560


<210>  2063
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  2063


Met Ala Ser Phe Gly Trp Lys Arg Lys Ile Gly Glu Lys Val Ser Lys 
1               5                   10                  15      


Val Thr Ser Gln Gln Phe Glu Ala Glu Ala Ala Asp Glu Lys Asp Val 
            20                  25                  30          


Val Asp Asn Asp Glu Gly Asn Trp Leu His Ala Ile Lys Arg Arg Lys 
        35                  40                  45              


Glu Ile Leu Leu Glu Gly Cys Ala Glu Lys Ser Lys Gln Leu Lys Asp 
    50                  55                  60                  


Glu Gly Ala Ser Leu Ala Trp Ile Val Val Lys Ser Glu Leu Ser Leu 
65                  70                  75                  80  


Ile Gly Val Pro Cys Pro Ser Gly Met Ser Trp Ser Ser Tyr Phe Cys 
                85                  90                  95      


Tyr Phe Gln Leu Met Trp Arg Lys Ala Met 
            100                 105     

<210>  2064
<211>  736
<212>  DNA
<213>  Homo sapiens

<400>  2064
tataaggagc agttgatact cataagttaa catttgtttg gttcccagtc ttcatgtaca     60

tgtgttccat ttaagaagtc atgatcatgt gtagtacaat tagaaaacct gttttcaaaa    120

aatattactt ctgttaactt gttaatttta atggtgaata tcatagttta gaaaatccac    180

cctccttttc ttgtcaggga ctgagtgtgt ggtcctgctc ctgttatgta tggaggcaaa    240

gggaaagggc tccggccccc tcaaaatcat gtctttggtg ccagccggtt ctgttctcag    300

tcacctggat actgaacttt cctgagcagg gcagaactga gatccagtgg gcttctcccc    360

aggatgctta cgctttttca tttgatttca ggtctcctct ttcgcttcct attgcaacca    420

atgaaggcca ttcttggtat tttacgcctt gattcttttg aggcttcttg acttgttcct    480

agtaattcaa ctcatctgtg acctcacttg actcttctcc tgttgaccta actccaagac    540

cttgttcccc actgacggga cgcgaggctg cgcggtaccg cgggggcggc tcctctcggt    600

gcgctcttca gcccgcgcag cctcattttc ccgcgctcgt gcgctgcggt cactcagggc    660

tgctgctaga gggcgcgccc agccgcgtgg ccctgactac tacaaatccc agaaggtcat    720

gcagtggggg cggccg                                                    736


<210>  2065
<211>  35
<212>  PRT
<213>  Homo sapiens

<400>  2065


Met Leu Thr Leu Phe His Leu Ile Ser Gly Leu Leu Phe Arg Phe Leu 
1               5                   10                  15      


Leu Gln Pro Met Lys Ala Ile Leu Gly Ile Leu Arg Leu Asp Ser Phe 
            20                  25                  30          


Glu Ala Ser 
        35  

<210>  2066
<211>  5123
<212>  DNA
<213>  Homo sapiens

<400>  2066
atgcgcagac tcagttcctg gagaaagatg gcgacagccg agaagcagaa acacgacggg     60

cgggtgaaga tcggccacta cattctgggt gacacgctgg gggtcggcac cttcggcaaa    120

gtgaaggttg gcaaacatga attgactggg cataaagtag ctgtgaagat actcaatcga    180

cagaagattc ggagccttga tgtggtagga aaaatccgca gagaaattca gaacctcaag    240

cttttcaggc atcctcatat aattaaactg taccaggtca tcagtacacc atctgatatt    300

ttcatggtga tggaatatgt ctcaggagga gagctatttg attatatctg taagaatgga    360

aggaaatctg atgtacctgg agtagtaaaa acaggctcca cgaaggagct ggatgaaaaa    420

gaaagtcggc gtctgttcca acagatcctt tctggtgtgg attattgtca caggcatatg    480

gtggtccata gagatttgaa acctgaaaat gtcctgcttg atgcacacat gaatgcaaag    540

atagctgatt ttggtctttc aaacatgatg tcagatggtg aatttttaag aacaagttgt    600

ggctcaccca actatgctgc accagaagta atttcaggaa gattgtatgc aggcccagag    660

gtagatatat ggagcagtgg ggttattctc tatgctttat tatgtggaac ccttccattt    720

gatgatgacc atgtgccaac tctttttaag aagatatgtg atgggatctt ctatacccct    780

caatatttaa atccttctgt gattagcctt ttgaaacata tgctgcaggt ggatcccatg    840

aagagggcca caatcaaaga tatcagggaa catgaatggt ttaaacagga ccttccaaaa    900

tatctctttc ctgaggatcc atcatatagt tcaaccatga ttgatgatga agccttaaaa    960

gaagtatgtg aaaagtttga gtgctcagaa gaggaagttc tcagctgtct ttacaacaga   1020

aatcaccagg atcctttggc agttgcctac catctcataa tagataacag gagaataatg   1080

aatgaagcca aagatttcta tttggcgaca agcccacctg attcttttct tgatgatcat   1140

cacctgactc ggccccatcc tgaaagagta ccattcttgg ttgctgaaac accaagggca   1200

cgccataccc ttgatgaatt aaatccacag aaatccaaac accaaggtgt aaggaaagca   1260

aaatggcatt taggaattag aagtcaaagt cgaccaaatg atattatggc agaagtatgt   1320

agagcaatca aacaattgga ttatgaatgg aaggttgtaa acccatatta tttgcgtgta   1380

cgaaggaaga atcctgtgac aagcacttac tccaaaatga gtctacagtt ataccaagtg   1440

gatagtagaa cttatctact ggatttccgt agtattgatg atgaaattac agaagccaaa   1500

tcagggactg ctactccaca gagatcggga tcagttagca actatcgatc ttgccaaagg   1560

agtgattcag atgctgaggc tcaaggaaaa tcctcagaag tttctcttac ctcatctgtg   1620

acctcacttg actcttctcc tgttgaccta actccaagac ctggaagtca cacaatagaa   1680

ttttttgaga tgtgtgcaaa tctaattaaa attcttgcac aataaacaga aaactttgct   1740

tatttctttt gcagcaataa gcatgcataa taagtcacag ccaaatgctt ccatttgtaa   1800

tcaagttata cataattata accgagggct ggcgttttgg aatgcaattt gcacagggat   1860

tggaacatga tttatagtta aaagcctaat atgcagaaat gaattaagat cattttgttg   1920

ttcattgtgc agtatgtata tagcataata tacacagtga attataggtc tcaggcttac   1980

ttgatttttg gctattttat atttagtgta cacagggctt tgaaatatta atttacataa   2040

aggccttcat atattattac gtgttatata ttacgtgtta taaatttatt caataaatat   2100

ttgcctagaa ttcccaagac ctttataggt gattttgttt tctgggctcc ttaacttcat   2160

aaatagctag tatcttccag cagtagtaac agtctggata acttcttcca tatccctccc   2220

tctttgtttt tttgagacag tgtcactttg tcacccaggc tggagtgcaa tggtgtggtc   2280

tcggctcact gcaacctcca cctcccgggt tcaagtgatt ctcccgcctc agcttcctga   2340

gtagctggaa ctacaggcgt gtgccaccac acccggctaa tttttcgtat ttttagtgta   2400

gacggggttt cactatgttg cccaggctgg tctcgaactc ctgaccgcgt gatccaccac   2460

ctcagcttcc caaagtggtg ggattacagg cgtgagccac cgcacccggc ctccatatcc   2520

cccttttaaa attctgtagt gtatggtaag tcatatcaga tatcagacct aatttaaatt   2580

tcattttagc tttacaagtc caaaaacaca gaatttatat attcagatac tctagcacta   2640

attttagtct taaaatattc ccacgatatt ctgtacacaa aatgttcttt ttgttacaag   2700

agctgagttg catatactgt agataaatca tattattttt gccaatttca caaattcctc   2760

tggcccatca tgtcagtcat tattgagtat atgcacacat tgctacttat ttgattatgt   2820

atcttttaaa ttgattcagt gcatagaaaa ctatctctta caaactttaa gtgctctgat   2880

atgacttccc ccccaaattt tattatgaac atttttaaaa acagaaaaat tgaaaaactg   2940

tttggtaagc acatgtatat ctaccattta gattcagcag ttgttaatgt tttgtcattt   3000

gttttctcta tacctatata tgtatagata cagctagtta tgcatatata tgcatatatg   3060

tgtttgtttg tgtatgtata tatgcttttt tccccctgaa ccatttggat gttacagaca   3120

tacttatcac cgtgaaaata cttcaagtat ctcctacaga taatgacatt ctcctaaaaa   3180

tccgtaatac cattgtaaaa gtaataattc cccaatatca tctaatcaag ccatatttaa   3240

atttctgaag ttaactccaa atttctttat agctgattat ttcaaactag gatccaatta   3300

aagtttacat atgacacttg gttataactc tttagttgga tataacatta ttattatttt   3360

gataaaatat ggaacaaatc aattctatta ataagtggtc acatttgttt tgggcttaaa   3420

ttacttttta aagatactgg attttcctaa gatttctgat ttacactgat attttttttt   3480

gtcattctta attgcatcac acaatagatg taaatgaaga tgtagtcacc tcagataaaa   3540

ttggtatcgt gtatgataat attgtatcat ttatatttgc cttatgttaa ctttaagaaa   3600

ttgatttttt tgtattaatc attttcccat tgcaacagag ctatattttt tctattttaa   3660

gaatcatatt ttaggattat ttttggcaaa tacagtgagc acttatgtaa ccagatgata   3720

atgaactcaa atgtcatgat agcttgcata aatggtgact ctagtagatt tgactcaagc   3780

acttctagaa tcatgcactg aattcaaaag aaaaatcttg ctgctttttg tccagggctt   3840

gttctattca acttctaatt tgaaagctgt acaaagtaat agaagttcca tttaaatatg   3900

agttcaaaac tgtatttact ttttatgtgg ccctctcttt aggggattct aattttactt   3960

agggtctcta agtgcagcat aatgttcctg atgttaacag aagactgtat ttttaaagtt   4020

acaaatttgt atatggaatt aagtaatggc gctatatacg ctgttgtggg gaggggggaa   4080

gaaaaggagg aaccaattaa ataggacctt ttaaaaattg ttaattttgt aaactttgct   4140

tctcttataa gttattgtga ttcattttag ttactgtgtt ttattttgaa aatatttaaa   4200

tattgcactt ctataaatag tatgataaat gcacagacaa ttgcagtaaa ttctttttta   4260

agctaggata tttgaaatga caacctttgg ttaagtgtgt caaggttgca acagaatttt   4320

cacaattttt ttgttgtttg caaattgtta ctaatattga agaggtaagg gaggcaatgc   4380

aaatgatttt taatcttttt ttattatctt ttcagcagtt tatatttttt gtgactttat   4440

gcaaccatat ttttactttg tcttgacaac tgaaagatgt ataaggtttt ttgccagaaa   4500

tgtactgtat acatagtttt aagtataaca gattttactg atatgtaaaa attttgccat   4560

taaaataaat gatttctcac tgagaggaac ttttctacca ggttggggca tatgggagct   4620

taatatatca tatctaattt aaaataattt cactgaaata aactccattg cttttaccta   4680

atttttttct tgagatgctt ttgtagtttt tcagagtttt agatgatttt atacaaaatc   4740

ctctgcctag cactgctctt tttgatgttg tagtgacacc atttacattg aattaatgct   4800

tggtagcctg gggctagatg tggaactcca tggatctgtg ttctgactgg cacctttgga   4860

atgaaagaaa agtgtgtgct gtccaaattt tttcccctta attctttccc tcatcttctc   4920

acccataata gaaattttat ttccattgtg agttctgaca agaatgaaat tccacataca   4980

acataactgt aaattgttgg taggtagaag ttaatatttg tggttcatgt atattttgac   5040

cagagtatat ttaagtatat aatttcagct tccttgattt agaaatatga tataataaag   5100

aaaaactcca tttatcatct gtt                                           5123


<210>  2067
<211>  574
<212>  PRT
<213>  Homo sapiens

<400>  2067


Met Arg Arg Leu Ser Ser Trp Arg Lys Met Ala Thr Ala Glu Lys Gln 
1               5                   10                  15      


Lys His Asp Gly Arg Val Lys Ile Gly His Tyr Ile Leu Gly Asp Thr 
            20                  25                  30          


Leu Gly Val Gly Thr Phe Gly Lys Val Lys Val Gly Lys His Glu Leu 
        35                  40                  45              


Thr Gly His Lys Val Ala Val Lys Ile Leu Asn Arg Gln Lys Ile Arg 
    50                  55                  60                  


Ser Leu Asp Val Val Gly Lys Ile Arg Arg Glu Ile Gln Asn Leu Lys 
65                  70                  75                  80  


Leu Phe Arg His Pro His Ile Ile Lys Leu Tyr Gln Val Ile Ser Thr 
                85                  90                  95      


Pro Ser Asp Ile Phe Met Val Met Glu Tyr Val Ser Gly Gly Glu Leu 
            100                 105                 110         


Phe Asp Tyr Ile Cys Lys Asn Gly Arg Lys Ser Asp Val Pro Gly Val 
        115                 120                 125             


Val Lys Thr Gly Ser Thr Lys Glu Leu Asp Glu Lys Glu Ser Arg Arg 
    130                 135                 140                 


Leu Phe Gln Gln Ile Leu Ser Gly Val Asp Tyr Cys His Arg His Met 
145                 150                 155                 160 


Val Val His Arg Asp Leu Lys Pro Glu Asn Val Leu Leu Asp Ala His 
                165                 170                 175     


Met Asn Ala Lys Ile Ala Asp Phe Gly Leu Ser Asn Met Met Ser Asp 
            180                 185                 190         


Gly Glu Phe Leu Arg Thr Ser Cys Gly Ser Pro Asn Tyr Ala Ala Pro 
        195                 200                 205             


Glu Val Ile Ser Gly Arg Leu Tyr Ala Gly Pro Glu Val Asp Ile Trp 
    210                 215                 220                 


Ser Ser Gly Val Ile Leu Tyr Ala Leu Leu Cys Gly Thr Leu Pro Phe 
225                 230                 235                 240 


Asp Asp Asp His Val Pro Thr Leu Phe Lys Lys Ile Cys Asp Gly Ile 
                245                 250                 255     


Phe Tyr Thr Pro Gln Tyr Leu Asn Pro Ser Val Ile Ser Leu Leu Lys 
            260                 265                 270         


His Met Leu Gln Val Asp Pro Met Lys Arg Ala Thr Ile Lys Asp Ile 
        275                 280                 285             


Arg Glu His Glu Trp Phe Lys Gln Asp Leu Pro Lys Tyr Leu Phe Pro 
    290                 295                 300                 


Glu Asp Pro Ser Tyr Ser Ser Thr Met Ile Asp Asp Glu Ala Leu Lys 
305                 310                 315                 320 


Glu Val Cys Glu Lys Phe Glu Cys Ser Glu Glu Glu Val Leu Ser Cys 
                325                 330                 335     


Leu Tyr Asn Arg Asn His Gln Asp Pro Leu Ala Val Ala Tyr His Leu 
            340                 345                 350         


Ile Ile Asp Asn Arg Arg Ile Met Asn Glu Ala Lys Asp Phe Tyr Leu 
        355                 360                 365             


Ala Thr Ser Pro Pro Asp Ser Phe Leu Asp Asp His His Leu Thr Arg 
    370                 375                 380                 


Pro His Pro Glu Arg Val Pro Phe Leu Val Ala Glu Thr Pro Arg Ala 
385                 390                 395                 400 


Arg His Thr Leu Asp Glu Leu Asn Pro Gln Lys Ser Lys His Gln Gly 
                405                 410                 415     


Val Arg Lys Ala Lys Trp His Leu Gly Ile Arg Ser Gln Ser Arg Pro 
            420                 425                 430         


Asn Asp Ile Met Ala Glu Val Cys Arg Ala Ile Lys Gln Leu Asp Tyr 
        435                 440                 445             


Glu Trp Lys Val Val Asn Pro Tyr Tyr Leu Arg Val Arg Arg Lys Asn 
    450                 455                 460                 


Pro Val Thr Ser Thr Tyr Ser Lys Met Ser Leu Gln Leu Tyr Gln Val 
465                 470                 475                 480 


Asp Ser Arg Thr Tyr Leu Leu Asp Phe Arg Ser Ile Asp Asp Glu Ile 
                485                 490                 495     


Thr Glu Ala Lys Ser Gly Thr Ala Thr Pro Gln Arg Ser Gly Ser Val 
            500                 505                 510         


Ser Asn Tyr Arg Ser Cys Gln Arg Ser Asp Ser Asp Ala Glu Ala Gln 
        515                 520                 525             


Gly Lys Ser Ser Glu Val Ser Leu Thr Ser Ser Val Thr Ser Leu Asp 
    530                 535                 540                 


Ser Ser Pro Val Asp Leu Thr Pro Arg Pro Gly Ser His Thr Ile Glu 
545                 550                 555                 560 


Phe Phe Glu Met Cys Ala Asn Leu Ile Lys Ile Leu Ala Gln 
                565                 570                 

<210>  2068
<211>  5084
<212>  DNA
<213>  Homo sapiens

<400>  2068
agcgccatgc gcagactcag ttcctggaga aagatggcga cagccgagaa gcagaaacac     60

gacgggcggg tgaagatcgg ccactacatt ctgggtgaca cgctgggggt cggcaccttc    120

ggcaaagtga aggttggcaa acatgaattg actgggcata aagtagctgt gaagatactc    180

aatcgacaga agattcggag ccttgatgtg gtaggaaaaa tccgcagaga aattcagaac    240

ctcaagcttt tcaggcatcc tcatataatt aaactgtacc aggtcatcag tacaccatct    300

gatattttca tggtgatgga atatgtctca ggaggagagc tatttgatta tatctgtaag    360

aatggaaggc tggatgaaaa agaaagtcgg cgtctgttcc aacagatcct ttctggtgtg    420

gattattgtc acaggcatat ggtggtccat agagatttga aacctgaaaa tgtcctgctt    480

gatgcacaca tgaatgcaaa gatagctgat tttggtcttt caaacatgat gtcagatggt    540

gaatttttaa gaacaagttg tggctcaccc aactatgctg caccagaagt aatttcagga    600

agattgtatg caggcccaga ggtagatata tggagcagtg gggttattct ctatgcttta    660

ttatgtggaa cccttccatt tgatgatgac catgtgccaa ctctttttaa gaagatatgt    720

gatgggatct tctatacccc tcaatattta aatccttctg tgattagcct tttgaaacat    780

atgctgcagg tggatcccat gaagagggcc acaatcaaag atatcaggga acatgaatgg    840

tttaaacagg accttccaaa atatctcttt cctgaggatc catcatatag ttcaaccatg    900

attgatgatg aagccttaaa agaagtatgt gaaaagtttg agtgctcaga agaggaagtt    960

ctcagctgtc tttacaacag aaatcaccag gatcctttgg cagttgccta ccatctcata   1020

atagataaca ggagaataat gaatgaagcc aaagatttct atttggcgac aagcccacct   1080

gattcttttc ttgatgatca tcacctgact cggccccatc ctgaaagagt accattcttg   1140

gttgctgaaa caccaagggc acgccatacc cttgatgaat taaatccaca gaaatccaaa   1200

caccaaggtg taaggaaagc aaaatggcat ttaggaatta gaagtcaaag tcgaccaaat   1260

gatattatgg cagaagtatg tagagcaatc aaacaattgg attatgaatg gaaggttgta   1320

aacccatatt atttgcgtgt acgaaggaag aatcctgtga caagcactta ctccaaaatg   1380

agtctacagt tataccaagt ggatagtaga acttatctac tggatttccg tagtattgat   1440

gatgaaatta cagaagccaa atcagggact gctactccac agagatcggg atcagttagc   1500

aactatcgat cttgccaaag gagtgattca gatgctgagg ctcaaggaaa atcctcagaa   1560

gtttctctta cctcatctgt gacctcactt gactcttctc ctgttgacct aactccaaga   1620

cctggaagtc acacaataga attttttgag atgtgtgcaa atctaattaa aattcttgca   1680

caataaacag aaaactttgc ttatttcttt tgcagcaata agcatgcata ataagtcaca   1740

gccaaatgct tccatttgta atcaagttat acataattat aaccgagggc tggcgttttg   1800

gaatgcaatt tgcacaggga ttggaacatg atttatagtt aaaagcctaa tatgcagaaa   1860

tgaattaaga tcattttgtt gttcattgtg cagtatgtat atagcataat atacacagtg   1920

aattataggt ctcaggctta cttgattttt ggctatttta tatttagtgt acacagggct   1980

ttgaaatatt aatttacata aaggccttca tatattatta cgtgttatat attacgtgtt   2040

ataaatttat tcaataaata tttgcctaga attcccaaga cctttatagg tgattttgtt   2100

ttctgggctc cttaacttca taaatagcta gtatcttcca gcagtagtaa cagtctggat   2160

aacttcttcc atatccctcc ctctttgttt ttttgagaca gtgtcacttt gtcacccagg   2220

ctggagtgca atggtgtggt ctcggctcac tgcaacctcc acctcccggg ttcaagtgat   2280

tctcccgcct cagcttcctg agtagctgga actacaggcg tgtgccacca cacccggcta   2340

atttttcgta tttttagtgt agacggggtt tcactatgtt gcccaggctg gtctcgaact   2400

cctgaccgcg tgatccacca cctcagcttc ccaaagtggt gggattacag gcgtgagcca   2460

ccgcacccgg cctccatatc ccccttttaa aattctgtag tgtatggtaa gtcatatcag   2520

atatcagacc taatttaaat ttcattttag ctttacaagt ccaaaaacac agaatttata   2580

tattcagata ctctagcact aattttagtc ttaaaatatt cccacgatat tctgtacaca   2640

aaatgttctt tttgttacaa gagctgagtt gcatatactg tagataaatc atattatttt   2700

tgccaatttc acaaattcct ctggcccatc atgtcagtca ttattgagta tatgcacaca   2760

ttgctactta tttgattatg tatcttttaa attgattcag tgcatagaaa actatctctt   2820

acaaacttta agtgctctga tatgacttcc cccccaaatt ttattatgaa catttttaaa   2880

aacagaaaaa ttgaaaaact gtttggtaag cacatgtata tctaccattt agattcagca   2940

gttgttaatg ttttgtcatt tgttttctct atacctatat atgtatagat acagctagtt   3000

atgcatatat atgcatatat gtgtttgttt gtgtatgtat atatgctttt ttccccctga   3060

accatttgga tgttacagac atacttatca ccgtgaaaat acttcaagta tctcctacag   3120

ataatgacat tctcctaaaa atccgtaata ccattgtaaa agtaataatt ccccaatatc   3180

atctaatcaa gccatattta aatttctgaa gttaactcca aatttcttta tagctgatta   3240

tttcaaacta ggatccaatt aaagtttaca tatgacactt ggttataact ctttagttgg   3300

atataacatt attattattt tgataaaata tggaacaaat caattctatt aataagtggt   3360

cacatttgtt ttgggcttaa attacttttt aaagatactg gattttccta agatttctga   3420

tttacactga tatttttttt tgtcattctt aattgcatca cacaatagat gtaaatgaag   3480

atgtagtcac ctcagataaa attggtatcg tgtatgataa tattgtatca tttatatttg   3540

ccttatgtta actttaagaa attgattttt ttgtattaat cattttccca ttgcaacaga   3600

gctatatttt ttctatttta agaatcatat tttaggatta tttttggcaa atacagtgag   3660

cacttatgta accagatgat aatgaactca aatgtcatga tagcttgcat aaatggtgac   3720

tctagtagat ttgactcaag cacttctaga atcatgcact gaattcaaaa gaaaaatctt   3780

gctgcttttt gtccagggct tgttctattc aacttctaat ttgaaagctg tacaaagtaa   3840

tagaagttcc atttaaatat gagttcaaaa ctgtatttac tttttatgtg gccctctctt   3900

taggggattc taattttact tagggtctct aagtgcagca taatgttcct gatgttaaca   3960

gaagactgta tttttaaagt tacaaatttg tatatggaat taagtaatgg cgctatatac   4020

gctgttgtgg ggagggggga agaaaaggag gaaccaatta aataggacct tttaaaaatt   4080

gttaattttg taaactttgc ttctcttata agttattgtg attcatttta gttactgtgt   4140

tttattttga aaatatttaa atattgcact tctataaata gtatgataaa tgcacagaca   4200

attgcagtaa attctttttt aagctaggat atttgaaatg acaacctttg gttaagtgtg   4260

tcaaggttgc aacagaattt tcacaatttt tttgttgttt gcaaattgtt actaatattg   4320

aagaggtaag ggaggcaatg caaatgattt ttaatctttt tttattatct tttcagcagt   4380

ttatattttt tgtgacttta tgcaaccata tttttacttt gtcttgacaa ctgaaagatg   4440

tataaggttt tttgccagaa atgtactgta tacatagttt taagtataac agattttact   4500

gatatgtaaa aattttgcca ttaaaataaa tgatttctca ctgagaggaa cttttctacc   4560

aggttggggc atatgggagc ttaatatatc atatctaatt taaaataatt tcactgaaat   4620

aaactccatt gcttttacct aatttttttc ttgagatgct tttgtagttt ttcagagttt   4680

tagatgattt tatacaaaat cctctgccta gcactgctct ttttgatgtt gtagtgacac   4740

catttacatt gaattaatgc ttggtagcct ggggctagat gtggaactcc atggatctgt   4800

gttctgactg gcacctttgg aatgaaagaa aagtgtgtgc tgtccaaatt ttttcccctt   4860

aattctttcc ctcatcttct cacccataat agaaatttta tttccattgt gagttctgac   4920

aagaatgaaa ttccacatac aacataactg taaattgttg gtaggtagaa gttaatattt   4980

gtggttcatg tatattttga ccagagtata tttaagtata taatttcagc ttccttgatt   5040

tagaaatatg atataataaa gaaaaactcc atttatcatc tgtt                    5084


<210>  2069
<211>  559
<212>  PRT
<213>  Homo sapiens

<400>  2069


Met Arg Arg Leu Ser Ser Trp Arg Lys Met Ala Thr Ala Glu Lys Gln 
1               5                   10                  15      


Lys His Asp Gly Arg Val Lys Ile Gly His Tyr Ile Leu Gly Asp Thr 
            20                  25                  30          


Leu Gly Val Gly Thr Phe Gly Lys Val Lys Val Gly Lys His Glu Leu 
        35                  40                  45              


Thr Gly His Lys Val Ala Val Lys Ile Leu Asn Arg Gln Lys Ile Arg 
    50                  55                  60                  


Ser Leu Asp Val Val Gly Lys Ile Arg Arg Glu Ile Gln Asn Leu Lys 
65                  70                  75                  80  


Leu Phe Arg His Pro His Ile Ile Lys Leu Tyr Gln Val Ile Ser Thr 
                85                  90                  95      


Pro Ser Asp Ile Phe Met Val Met Glu Tyr Val Ser Gly Gly Glu Leu 
            100                 105                 110         


Phe Asp Tyr Ile Cys Lys Asn Gly Arg Leu Asp Glu Lys Glu Ser Arg 
        115                 120                 125             


Arg Leu Phe Gln Gln Ile Leu Ser Gly Val Asp Tyr Cys His Arg His 
    130                 135                 140                 


Met Val Val His Arg Asp Leu Lys Pro Glu Asn Val Leu Leu Asp Ala 
145                 150                 155                 160 


His Met Asn Ala Lys Ile Ala Asp Phe Gly Leu Ser Asn Met Met Ser 
                165                 170                 175     


Asp Gly Glu Phe Leu Arg Thr Ser Cys Gly Ser Pro Asn Tyr Ala Ala 
            180                 185                 190         


Pro Glu Val Ile Ser Gly Arg Leu Tyr Ala Gly Pro Glu Val Asp Ile 
        195                 200                 205             


Trp Ser Ser Gly Val Ile Leu Tyr Ala Leu Leu Cys Gly Thr Leu Pro 
    210                 215                 220                 


Phe Asp Asp Asp His Val Pro Thr Leu Phe Lys Lys Ile Cys Asp Gly 
225                 230                 235                 240 


Ile Phe Tyr Thr Pro Gln Tyr Leu Asn Pro Ser Val Ile Ser Leu Leu 
                245                 250                 255     


Lys His Met Leu Gln Val Asp Pro Met Lys Arg Ala Thr Ile Lys Asp 
            260                 265                 270         


Ile Arg Glu His Glu Trp Phe Lys Gln Asp Leu Pro Lys Tyr Leu Phe 
        275                 280                 285             


Pro Glu Asp Pro Ser Tyr Ser Ser Thr Met Ile Asp Asp Glu Ala Leu 
    290                 295                 300                 


Lys Glu Val Cys Glu Lys Phe Glu Cys Ser Glu Glu Glu Val Leu Ser 
305                 310                 315                 320 


Cys Leu Tyr Asn Arg Asn His Gln Asp Pro Leu Ala Val Ala Tyr His 
                325                 330                 335     


Leu Ile Ile Asp Asn Arg Arg Ile Met Asn Glu Ala Lys Asp Phe Tyr 
            340                 345                 350         


Leu Ala Thr Ser Pro Pro Asp Ser Phe Leu Asp Asp His His Leu Thr 
        355                 360                 365             


Arg Pro His Pro Glu Arg Val Pro Phe Leu Val Ala Glu Thr Pro Arg 
    370                 375                 380                 


Ala Arg His Thr Leu Asp Glu Leu Asn Pro Gln Lys Ser Lys His Gln 
385                 390                 395                 400 


Gly Val Arg Lys Ala Lys Trp His Leu Gly Ile Arg Ser Gln Ser Arg 
                405                 410                 415     


Pro Asn Asp Ile Met Ala Glu Val Cys Arg Ala Ile Lys Gln Leu Asp 
            420                 425                 430         


Tyr Glu Trp Lys Val Val Asn Pro Tyr Tyr Leu Arg Val Arg Arg Lys 
        435                 440                 445             


Asn Pro Val Thr Ser Thr Tyr Ser Lys Met Ser Leu Gln Leu Tyr Gln 
    450                 455                 460                 


Val Asp Ser Arg Thr Tyr Leu Leu Asp Phe Arg Ser Ile Asp Asp Glu 
465                 470                 475                 480 


Ile Thr Glu Ala Lys Ser Gly Thr Ala Thr Pro Gln Arg Ser Gly Ser 
                485                 490                 495     


Val Ser Asn Tyr Arg Ser Cys Gln Arg Ser Asp Ser Asp Ala Glu Ala 
            500                 505                 510         


Gln Gly Lys Ser Ser Glu Val Ser Leu Thr Ser Ser Val Thr Ser Leu 
        515                 520                 525             


Asp Ser Ser Pro Val Asp Leu Thr Pro Arg Pro Gly Ser His Thr Ile 
    530                 535                 540                 


Glu Phe Phe Glu Met Cys Ala Asn Leu Ile Lys Ile Leu Ala Gln 
545                 550                 555                 

<210>  2070
<211>  1635
<212>  DNA
<213>  Homo sapiens

<400>  2070
agcgccatgc gcagactcag ttcctggaga aagatggcga cagccgagaa gcagaaacac     60

gacgggcggg tgaagatcgg ccactacatt ctgggtgaca cgctgggggt cggcaccttc    120

ggcaaagtga aggttggcaa acatgaattg actgggcata aagtagctgt gaagatactc    180

aatcgacaga agattcggag ccttgatgtg gtaggaaaaa tccgcagaga aattcagaac    240

ctcaagcttt tcaggcatcc tcatataatt aaactgtacc aggtcatcag tacaccatct    300

gatattttca tggtgatgga atatgtctca ggaggagagc tatttgatta tatctgtaag    360

aatggaaggc tggatgaaaa agaaagtcgg cgtctgttcc aacagatcct ttctggtgtg    420

gattattgtc acaggcatat ggtggtccat agagatttga aacctgaaaa tgtcctgctt    480

gatgcacaca tgaatgcaaa gatagctgat tttggtcttt caaacatgat gtcagatggt    540

gaatttttaa gaacaagttg tggctcaccc aactatgctg caccagaagt aatttcagga    600

agagactgca atattataag aattttaacc tctcaattta ctaactacca gcattgagaa    660

catgaagata tttgtacagt gtcgcttttt gaatagtttg gaaaacagga gaatttaata    720

tttttaagaa taactctttg tccttcacta tactactgaa attgaaaaca gaagctgaag    780

tttgctagat ttataatgaa cttttaataa cttttcaccc aaaccatgct tatttgtgtg    840

aatgttttgc atcttgatta actcaatgca gaaatactgt agtattttct atttttataa    900

gcttgttggc ctagactgct caaagaaatg agatttgtgt aaaaatatgg ctgtgagtaa    960

ggcaggagta cctaatttta gatttgtcaa gtttcatctt ttttttaaat attaacttaa   1020

tgtcaaaaat tatttaaaaa atttttaaaa aaatggtgtt gtctatctta attcttttag   1080

gaataaaaca attcaggaca tggagactgt ggaaagttgt tatttaaata aataaaaaga   1140

aatgttataa ctgtgcatat atgcaatggg ctattactga aatttaattt ttctagtttg   1200

gataaagtct ttcttcaagc tcttggtgta tgagaacttt tactttcaaa ataatattta   1260

tcgatcagtt cagcagtaca taaatttaaa gaaatccttt tcctgaatcc aggctttgaa   1320

tgggtgatct aactagtctg cagctagtta aggcacttga ctacaatgca ctgcaaacgg   1380

gatttaaaaa ctctgtgaac caatttgcct ggctttcttt cacagcctca ggatcctttc   1440

accttggtgt aaggggtctt gtgttattgg gattgtgggc tcagagtcca ttactaaaga   1500

acattctcag ttgatgaaat atcacttaat ctctcctctg taacaaaaac caatggtttt   1560

aaattgaata gtgatatgtt tgttcaagat ttggccctat tgtcagatcc catcagggcc   1620

atagtaaata gtaga                                                    1635


<210>  2071
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  2071


Met Arg Arg Leu Ser Ser Trp Arg Lys Met Ala Thr Ala Glu Lys Gln 
1               5                   10                  15      


Lys His Asp Gly Arg Val Lys Ile Gly His Tyr Ile Leu Gly Asp Thr 
            20                  25                  30          


Leu Gly Val Gly Thr Phe Gly Lys Val Lys Val Gly Lys His Glu Leu 
        35                  40                  45              


Thr Gly His Lys Val Ala Val Lys Ile Leu Asn Arg Gln Lys Ile Arg 
    50                  55                  60                  


Ser Leu Asp Val Val Gly Lys Ile Arg Arg Glu Ile Gln Asn Leu Lys 
65                  70                  75                  80  


Leu Phe Arg His Pro His Ile Ile Lys Leu Tyr Gln Val Ile Ser Thr 
                85                  90                  95      


Pro Ser Asp Ile Phe Met Val Met Glu Tyr Val Ser Gly Gly Glu Leu 
            100                 105                 110         


Phe Asp Tyr Ile Cys Lys Asn Gly Arg Leu Asp Glu Lys Glu Ser Arg 
        115                 120                 125             


Arg Leu Phe Gln Gln Ile Leu Ser Gly Val Asp Tyr Cys His Arg His 
    130                 135                 140                 


Met Val Val His Arg Asp Leu Lys Pro Glu Asn Val Leu Leu Asp Ala 
145                 150                 155                 160 


His Met Asn Ala Lys Ile Ala Asp Phe Gly Leu Ser Asn Met Met Ser 
                165                 170                 175     


Asp Gly Glu Phe Leu Arg Thr Ser Cys Gly Ser Pro Asn Tyr Ala Ala 
            180                 185                 190         


Pro Glu Val Ile Ser Gly Arg Asp Cys Asn Ile Ile Arg Ile Leu Thr 
        195                 200                 205             


Ser Gln Phe Thr Asn Tyr Gln His 
    210                 215     

<210>  2072
<211>  461
<212>  DNA
<213>  Homo sapiens

<400>  2072
agactcagtt cctggagaaa gatggcgaca gccgagaagc agaaacacga cgggcgggtg     60

aagatcggcc actacattct gggtgacacg ctgggggtcg gcaccttcgg caaagtgaag    120

gttggcaaac atgaattgac tgggcataaa gtagctgtga agatactcaa tcgacagaag    180

attcggagcc ttgatgtggt aggaaaaatc cgcagagaaa ttcagaacct caagcttttc    240

aggcatcctc atataattaa actgtaccag gtcatcagta caccatctga tattttcatg    300

gtgatggaat atgtctcagg aggagagcta tttgattata tctgtaagaa tggaaggctg    360

gatgaaaaag aaagtcggcg tctgttccaa cagatccttt ctggtgtgga ttattgtcac    420

aggcatatgg tggtccatag agatttgaaa cctgaaaatg t                        461


<210>  2073
<211>  145
<212>  PRT
<213>  Homo sapiens

<400>  2073


Met Ala Thr Ala Glu Lys Gln Lys His Asp Gly Arg Val Lys Ile Gly 
1               5                   10                  15      


His Tyr Ile Leu Gly Asp Thr Leu Gly Val Gly Thr Phe Gly Lys Val 
            20                  25                  30          


Lys Val Gly Lys His Glu Leu Thr Gly His Lys Val Ala Val Lys Ile 
        35                  40                  45              


Leu Asn Arg Gln Lys Ile Arg Ser Leu Asp Val Val Gly Lys Ile Arg 
    50                  55                  60                  


Arg Glu Ile Gln Asn Leu Lys Leu Phe Arg His Pro His Ile Ile Lys 
65                  70                  75                  80  


Leu Tyr Gln Val Ile Ser Thr Pro Ser Asp Ile Phe Met Val Met Glu 
                85                  90                  95      


Tyr Val Ser Gly Gly Glu Leu Phe Asp Tyr Ile Cys Lys Asn Gly Arg 
            100                 105                 110         


Leu Asp Glu Lys Glu Ser Arg Arg Leu Phe Gln Gln Ile Leu Ser Gly 
        115                 120                 125             


Val Asp Tyr Cys His Arg His Met Val Val His Arg Asp Leu Lys Pro 
    130                 135                 140                 


Glu 
145 

<210>  2074
<211>  2256
<212>  DNA
<213>  Homo sapiens

<400>  2074
tcctggagaa agatggcgac agccgagaag cagaaacacg acgggcgggt gaagatcggc     60

cactacattc tgggtgacac gctgggggtc ggcaccttcg gcaaagtgaa ggttggcaaa    120

catgaattga ctgggcataa agtagctgtg aagatactca atcgacagaa gattcggagc    180

cttgatgtgg taggaaaaat ccgttaaaga tgcttaggtt tttctcctga actggctgac    240

tcaaacttgt ttcactctta cctcttctca tttgttgagt gctaggtttt aaataccatc    300

catatgctga ccacccctaa atgtacatct cttgctttaa gatctcttct tacaccagac    360

ttatttgctc actgctgact ttacatttcc atttggatgt tcgcaagaca tttaaaactc    420

aacccggccc aaaatgaact ctttattact ctcccaaacc tgctcttccc acagttttca    480

ccatcttggc taacagccaa tgacccaggg ctaaaactta ggaaccattt ttaacttccc    540

tgtttctttc actttctacc atgcatttca tttcttcctt cacaatcaag ctaggatttg    600

attgcttctc agttccttta ttgctgtcaa cctggtctca gccaccatct gtctcatgaa    660

atcctgaagt aacctcctgt ggctaccttt actgttgaca gttaattctt cacattgctg    720

ccatagtttt acttttaata tgccagatca catgactgct taaaacgtac gatagctttt    780

catcttcctt ggagtaaaag ccaaagcctt atcatggctt gtaaaattct gtgtcttctg    840

gcctgcagtt aacacctttg actctacatc ctatttctct ctaatattcc tcgaacatgc    900

caagcaggct tctacttggg gacctttgca gttgctattc cctctcccag tttcgctttc    960

ctcctagata attacataat ttgttcccat tcttctttta ggctcagctc aaatgttact   1020

ttattagagg ctttccttta gcactctgta tacaaagatt ccccttcatt tgctttattt   1080

ttcttcatag catgttccac cacctgagat attgcttatt tatttagtgt ctgtttcctg   1140

gttcctggaa catgaactcc atgagagcag agaatttttg tttcctgcag tttttctagc   1200

tcctagccta gtacctggta tactataggt gcttagtaaa tatttattga atgaatgaat   1260

atatgtgttt taatatttgt agacaatgtt ttctctcacc aggtaccagg tcatcagtac   1320

accatctgat attttcatgg tgatggaata tgtctcagga ggagagctat ttgattatat   1380

ctgtaagaat ggaagggtaa gctgttctgc tttaattctg tatgtatttt gtaactcccc   1440

tttatccttt actagcatca aaatgtcagc aaccaatttt aagaggtcta tttaataacc   1500

agttccctta gtcatatatt tgtttagaat cataaactat gtagaactag aaaggatctt   1560

aaagattatc tccttagcct gtttatacag atgtggatac tgagcctcgc ggcttatatg   1620

attgctcaca gtaacgtgat ttattaatga cggaattggc ttgagccccc agaactcata   1680

atcctcagac ttatgcttcc agggtataca aatactttga atatgtatct taatgtaatt   1740

aatcgttaca aaatatatta ttattactta aagatctagg ccttgctagt caattctagc   1800

cacatttaaa ttgcattcat tttttggttt cagaaatctg atgtacctgg agtagtaaaa   1860

acaggctcca cgaaggaggt aggaattaga tataaagaat ttacagctgg aaggaacttt   1920

gtaggacatt ttgaacacta ccttaagtta cagatacaaa aactcaacac tgccctctgc   1980

ccatactttt tctcataccc aggttatgtg gtatgcaaaa gcccctttgt gggagagctg   2040

tagctagccc tgaaaagaga gcttttctct caattttaag ttatttacat tactcattca   2100

tttgttctat atagcatgtc tatttacttt tatcaaaatc aaacttatta accaagttaa   2160

ttttgatttt actatttctt aacatgattc atttctattt caggtactcc cctttactcc   2220

tgcttctcct taccaaaaaa aaaaaaaaaa aaaaaa                             2256


<210>  2075
<211>  64
<212>  PRT
<213>  Homo sapiens

<400>  2075


Met Ala Thr Ala Glu Lys Gln Lys His Asp Gly Arg Val Lys Ile Gly 
1               5                   10                  15      


His Tyr Ile Leu Gly Asp Thr Leu Gly Val Gly Thr Phe Gly Lys Val 
            20                  25                  30          


Lys Val Gly Lys His Glu Leu Thr Gly His Lys Val Ala Val Lys Ile 
        35                  40                  45              


Leu Asn Arg Gln Lys Ile Arg Ser Leu Asp Val Val Gly Lys Ile Arg 
    50                  55                  60                  

<210>  2076
<211>  1428
<212>  DNA
<213>  Homo sapiens

<400>  2076
atgcgcagac tcagttcctg gagaaagatg gcgacagccg agaagcagaa acacgacggg     60

cgggtgaaga tcggccacta cattctgggt gacacgctgg gggtcggcac cttcggcaaa    120

gtgaaggttg gcaaacatga attgactggg cataaagtag ctgtgaagat actcaatcga    180

cagaagattc ggagccttga tgtggtagga aaaatccgca gagaaattca gaacctcaag    240

cttttcaggc atcctcatat aattaaactg taagctctgt ttatattaaa tatagtccag    300

tcatcttttc atcttttttg ttaacctact taatgtgaca agtgagaaaa atgactgaca    360

cttctttttg tttcctaagg gttttgaaaa gtttcttcct aggctgtgtg cggtggctca    420

cacctgtaat tccagtactt tgggaggctg aggcaggcgg atcacctgag gtcaggagtt    480

cgagaccagc ctggccaaca tggtgaaacc ctgtctccag taaaaataca aaaattagct    540

gggcatggtg gtgggcgcct gtaataccag ctactcggga ggctaaggca ggagaatggc    600

ttgaacctgg gaggcggagg ttgcagtgag ctgagatcgt gccattgcac tccagcttgg    660

gcaacaaaag cgaaactctg tcccaaaaaa aaataaaagt ttcttcccat tcatgtattt    720

ttctaacccc attgatggtc atttaagcct gtgttcatgt tttgcccttg tgcttatcag    780

ctgttatctt ctcattcttt cctgtctcct ggaaagatgc tcttctggta atgtttggtg    840

ccccattgct gtaaaaccaa cagtgatctg ctagtaaaaa ctcttgacct ccaaatgccc    900

acatgatgtc agttagcctc actagtgaga atgcggtagt agaaagggtt tttccccatc    960

ctgcttatac ctgaacatat agataacaaa atttcaggaa tccaaggttt caaaagggca   1020

gtaatcttac tgttgtttta cagttgccag ttatagagtc tacaaataac tatttcctgc   1080

tcagcttctg ctttgttatg caggcaataa cttaaagatg cttaggtttt tctcctgaac   1140

tggctgactc aaacttgttt cactcttacc tcttctcatt tgttgagtgc taggttttaa   1200

ataccatcca tatgctgacc acccctaaat gtacatctct tgctttaaga tctcttctta   1260

caccagactt atttgctcac tgctgacttt acatttccat ttggatgttc gcaagacatt   1320

taaaactcaa cccggcccaa aatgaactct ttattactct cccaaacctg ctcttcccac   1380

agttttcacc atcttggcta acagccaatg acccagggct aaaactta                1428


<210>  2077
<211>  90
<212>  PRT
<213>  Homo sapiens

<400>  2077


Met Arg Arg Leu Ser Ser Trp Arg Lys Met Ala Thr Ala Glu Lys Gln 
1               5                   10                  15      


Lys His Asp Gly Arg Val Lys Ile Gly His Tyr Ile Leu Gly Asp Thr 
            20                  25                  30          


Leu Gly Val Gly Thr Phe Gly Lys Val Lys Val Gly Lys His Glu Leu 
        35                  40                  45              


Thr Gly His Lys Val Ala Val Lys Ile Leu Asn Arg Gln Lys Ile Arg 
    50                  55                  60                  


Ser Leu Asp Val Val Gly Lys Ile Arg Arg Glu Ile Gln Asn Leu Lys 
65                  70                  75                  80  


Leu Phe Arg His Pro His Ile Ile Lys Leu 
                85                  90  

<210>  2078
<211>  425
<212>  DNA
<213>  Homo sapiens

<400>  2078
ggagaaagat ggcgacagcc gagaagcaga aacacgacgg gcgggtgaag atcggccact     60

acattctggg tgacacgctg ggggtcggca ccttcggcaa agtgaaggtt ggcaaacatg    120

aattgactgg gcataaagta gctgtgaaga tactcaatcg acagaagatt cggagccttg    180

atgtggtagg aaaaatccgc agagaaattc agaacctcaa gcttttcagg catcctcata    240

taattaaact ggttttgaaa agtttcttcc taggctgtgt gcggtggctc acacctgtaa    300

ttccagtact ttgggaggct gaggcaggcg gatcacctga ggtcaggagt tcgagaccag    360

cctggccaac atggtgaaac cctgtctcca gtaaaaatac aaaaattagc tgggcatggt    420

ggtgg                                                                425


<210>  2079
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  2079


Met Ala Thr Ala Glu Lys Gln Lys His Asp Gly Arg Val Lys Ile Gly 
1               5                   10                  15      


His Tyr Ile Leu Gly Asp Thr Leu Gly Val Gly Thr Phe Gly Lys Val 
            20                  25                  30          


Lys Val Gly Lys His Glu Leu Thr Gly His Lys Val Ala Val Lys Ile 
        35                  40                  45              


Leu Asn Arg Gln Lys Ile Arg Ser Leu Asp Val Val Gly Lys Ile Arg 
    50                  55                  60                  


Arg Glu Ile Gln Asn Leu Lys Leu Phe Arg His Pro His Ile Ile Lys 
65                  70                  75                  80  


Leu Val Leu Lys Ser Phe Phe Leu Gly Cys Val Arg Trp Leu Thr Pro 
                85                  90                  95      


Val Ile Pro Val Leu Trp Glu Ala Glu Ala Gly Gly Ser Pro Glu Val 
            100                 105                 110         


Arg Ser Ser Arg Pro Ala Trp Pro Thr Trp 
        115                 120         

<210>  2080
<211>  317
<212>  DNA
<213>  Homo sapiens

<400>  2080
aaaaaattta aaacacagag aaaccaaaaa aataaaagaa tttaaaaata cgaaaaggta     60

tacagcaaaa aagtctcctt cccctcttcc tttagtcttc tagctttctc ttctggaaga    120

aaccactgtt accaatttct tatgtattct cctatgtaat cactcttaaa catctgaaca    180

tttgggatga atctggcaaa agagaaaata acttatattt gcttagctat tttctgagga    240

tgctagatga ctactcttat aatatgtcta aatatattat tatttttatt ttgttgaggc    300

agagtctcaa tcatcac                                                   317


<210>  2081
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  2081


Lys Asn Leu Lys His Arg Glu Thr Lys Lys Ile Lys Glu Phe Lys Asn 
1               5                   10                  15      


Thr Lys Arg Tyr Thr Ala Lys Lys Ser Pro Ser Pro Leu Pro Leu Val 
            20                  25                  30          


Phe 
    

<210>  2082
<211>  2273
<212>  DNA
<213>  Homo sapiens

<400>  2082
actgggctag cttcatatca gatttacttg ttaagtgact gttttggaat gtttactttt     60

ggactgggtt tgtaacacgg ttaaaggcaa tgagaaacaa gcagaattcc aggagtcctt    120

gaagcagagg gcactggaag acaatatagc agattaaaat agcacagctc atgtggcata    180

ggtgggtatt ttagatgttt gagtaaattt gaaagagtat gatgtttaaa ttacctttag    240

caacatgttc atctgctatg ctgtcatgac tagggggatg attattagtc acatagagct    300

tgggagtacc actggaaacg tatgggtagg agtttaggtg gcttctgttt ttcaaaagat    360

gatcttatcc tagtatctgt aatgctcact tggcacacct gacttgtggg cggatcacaa    420

ggtcaagaga tcgagatcac cctggcccac atggtgagac cccaactcta ctaaaaatac    480

aaaaattagc tgggtgtggt ggcatgtgcc attggcttga gcccaagagt ttgagaccag    540

cctgggcaac ctggtgaaac ctcttctcca ttaaaaatac aaaaaattag ccaggcatgg    600

tggtatgtgc ctgtagtccc agctactcag ggagctgagg tggaaggatt gcttgagcct    660

gggaggtcaa ggctgcagtg aaccttgatt gtgccactgc actccagcct ggatgacaaa    720

gaccctgtct caagaaaagt ctgtaattct ttcctaaccc ttagtatcca gcctcagtcc    780

tgaggttttc tttacctctg ggggctattt tatgccggct ctctcctgag tgtcacacat    840

ctggtcctca ggaaacattc tcacatccct ggcctgaaaa aaacaatttc agggagatcg    900

catggcagca gccctctctg ggctccccag ctaaatggtt gtacgaaaca catttcaaag    960

ctctctgaag ggcttccttg aagttccttt cactgggttt caaagtagaa ggtagtaact   1020

cctttgtcca agaaggctga attgagcact taacaattct ccaaagaaat ttcttcattg   1080

gtctctatcc tagacccctt ctgtatcctt gatatggctg aggattctaa aaaatgacca   1140

gtcttacatg ggagggctgg gatataaaaa ataaaataat aaataatgat aaaaactgaa   1200

aactgaccac gttcttggat atgttttctt tgggttgtgt gtgtgtgtga gacttttgat   1260

agttacccaa agtaggaaaa atcccattct aataaggtta tatttatgta gctctgcaaa   1320

taaacatcta gcaaatgtaa aaagtatttt ctttgcctta aaaatgatta aaattatttg   1380

aactcctgag gagtgttata tgaataaaat tagtaagtta tttggaggaa agttattttt   1440

taaaaagaca actggtaaaa cagtacagga gaaaggccag cttcctcaag tgaggacagt   1500

tgtttagaat tgactgagga gcggccgggt gcggaggctc acatctgtaa tcccacacgc   1560

cttgggaggc tctgaggcgg gtagatcacc tgaggtcagg agtttgagac cagcctggcc   1620

aacatggcga aaccccgtct ccactaaaaa tacaaaaatt agccaggtgc agtggcacac   1680

acctgtaatc ccagctactc cgaaggctga ggcaggagga tcacctgagc ccaggaagtt   1740

gagactgcag tgagctgaga ttgcaccact gcactccagc ctcagtgaca gcgagactgt   1800

ctcaaaaaaa gaaaaaagtg actgaggagg aagaggccag gtggcaaatg gaacagaatc   1860

accaaagggt gaacaggact aaggcaatgt agtgtatggc tcagctacgt cagagtggaa   1920

aaggtgttat tagagcagaa actatggtcc ctgcgtcaca gggaagcaac ctacagagaa   1980

gcagcagctc cccaagagag gagagataag aagccagaag cctcagagtg aacaattgtc   2040

ctattaggga ttgctctaga gagagaaacc tctgggaacg tacccctgtg aggcagcaca   2100

gcacaatgct tttagaattg tatgagagtt gatatatctc catttgtttt gcaaaggcaa   2160

aaactaagat acagagatta tctgttaaag ttatgtattt ctttggtaat aaagatgctg   2220

acagtgttgc tggaatgcat ttctttaata aagatattgt acaatgaaat act          2273


<210>  2083
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  2083


Met Arg Val Asp Ile Ser Pro Phe Val Leu Gln Arg Gln Lys Leu Arg 
1               5                   10                  15      


Tyr Arg Asp Tyr Leu Leu Lys Leu Cys Ile Ser Leu Val Ile Lys Met 
            20                  25                  30          


Leu Thr Val Leu Leu Glu Cys Ile Ser Leu Ile Lys Ile Leu Tyr Asn 
        35                  40                  45              


Glu 
    

<210>  2084
<211>  8062
<212>  DNA
<213>  Homo sapiens

<400>  2084
cagaagcgag atggtgagtt gtgactgtgg tgtttgtgaa tcgcgttcca tcctcgtcct     60

ttgtgcctct ctgtttgctg tgcttggggg gctggcaaga ttccggataa ggggaactgg    120

tgggctggaa agaggcatgc ggtggccctc aagagccaga agaatgactg ctaactggtg    180

cctgggggac ctatcccgcc gtaattgtgg tgctagagcc gcattgtgtc ctttgcctcg    240

gtccaacctt tggagacctt tcacggctct agccttggtt gggagccgag ggaaggagtt    300

tgggaatgtt tggctctgtg taacaatgaa ataattcatt ggtgatgctc tctggccgga    360

gtctgtaaag ataaggtgca tttcagaaca ttgcaactct tgcggagggt tttaggtaac    420

gtgaaatgcg ggtagtggtc tctgacttgg cattcgtgga aagaggcttc tcccgcagtt    480

tcgatcttta cgattgcctt taaattttat cagtaattgg tttcccggag aactcgagta    540

aatctagaag ttgccaggtt tcagaactat ttattccttt aatgtgcaga cgaagggaac    600

gtcatcgttt ggaaagcgtc gcaataagac gcacacgttg tgccgccgct gtggctctaa    660

ggcctaccac cttcagaagt cgacctgtgg caaatgtggc taccctgcca agcgcaagag    720

aaagtataac tggagtgcca aggctaaaag acgaaatacc accggaaaac acctaaaccc    780

aagagggcag ctgttgcagc atccagttca tcttaagaat gtcaacgatt agtcatgcaa    840

taaatgttct ggttttaaaa aatacatatc tggttttggt aaggtatttt taatcaatta    900

ggcttgtagt atcagtgaaa tactgtaggt ttagggactg ggctagcttc atatcagatt    960

tacttgttaa gtgactgttt tggaatgttt acttttggac tgggtttgta acacggttaa   1020

aggcaatgag aaacaagcag aattccagga gtccttgaag cagagggcac tggaagacaa   1080

tatagcagat taaaatagca cagctcatgt ggcataggtg ggtattttag atgtttgagt   1140

aaatttgaaa gagtatgatg tttaaattac ctttagcaac atgttcatct gctatgctgt   1200

catgactagg gggatgatta ttagtcacat agagcttggg agtaccactg gaaacgtatg   1260

ggtaggagtt taggtggctt ctgtttttca aaagatgatc ttatcctagt atctgtaatg   1320

ctcacttggc acacctgact tgtgggctgt gtgtaaggtg gctagctaag tgaaaaaagc   1380

ctgctaggtg tgagtcaact taagaatatg taaataggtt tgagaaaaag tagggcttgg   1440

gtgcaagtaa agattgagca ggaaataaag gaaaatcaag tataatccct gagatttgta   1500

gactaaaggc aatgatgtgg gactacttgg tcgaattttt ttagccctca acttggtaat   1560

tgggtgtttc tgtgttaaag cactgaaact tgctgtcgtg ccttcctagt tttcgtggtt   1620

tattgacagg gttgggggtt ttttttgttt ttttaaaatg aagggacaaa gtcaactgga   1680

ctgctgagtg agagggcagg ggcagttgaa gggaacatga attgctggaa cagctacata   1740

aaatagtgat gtagccaagt catgctattt aaattataat tctccactgt gtttagaata   1800

acatctgagg ttcttaacct ggccttggaa gggtatcact tttacttgta acctggaatg   1860

gctttataat gtgctagcta attgctactc tcatcttgta ttttaactcc taatttaccc   1920

ttcaggtctc agcttcagaa cattcactta taaagaaacc ctgctgatta aatctctctt   1980

gggcttcctc ccgaaatgtg agactatact ttaaagatgt atggttagag tccaattgcc   2040

attgcctttc ttgtttacag atagtgcaat ggcgcaatcc tggctcactg cagcctctaa   2100

ttcctgggct caagtcaagt ggttctcctg cctcagcctt ctgagtagct gggactacag   2160

atgcacacca ccacacctgg ctaatttttg tgttttttgt agagatggag attcactcga   2220

ctaattcttt ttgtattctt agtagagact gggtttcaac atgttgacca ggctggtctc   2280

gaactcgacc tcgtgatccg ccgcctcggc ctcccaaagt gctaggatta caggcgtgag   2340

ccaccactcc cggctgtcat catcaaattt tcaagtgaag atagtctgtt gaagattgaa   2400

caatgacctt gaaagacagc tgagttgctg tgggtataat gtaaagctgg tgaagtttgg   2460

ccagtttggg cttcagaagt ctaagtctag tgaaggtacc ctgaccccca tataaacaac   2520

ccttgaggcc ggtgtggtgg ctcacggctg taatcctggc actttgggag gccgaggtgg   2580

gcggatcaca aggtcaagag atcgagatca ccctggccca catggtgaga ccccaactct   2640

actaaaaata caaaaattag ctgggtgtgg tggcatgtgc ctgtagtctt agctacttga   2700

gaggctgagg caggagaatc gcttgaacct gggaggcaga ggttgcagtg agctgagatc   2760

atgccactgt gctccagcct ggtggcacag tgagactcca cctcaaaaaa aaaaaaaaat   2820

ccttgaacta atgactcaaa ttttcaaatg aaacaaaata agcagtggat cttgcattgg   2880

agatggagtt aaactatgtt gcccaggctg gtcttggact cctggtttca agtgatcctc   2940

tcatcttggc ctcccaaagt gctgggatta cagggacgag ccaccacacc ccacctattg   3000

tctatatttc tatctttaac agcacttcag tcctgcctta agttatagtt atgtatagat   3060

acccattata ctttaaattt ttcagcagaa attatgcttt tatcttctct gcagtgttat   3120

atgttggtgt gcaaaaatgt taaatttatt tttcctaagt accccatctg cttttcaact   3180

ctgtcctctg cctgaaaagc ctccctccag cccctacttc cctcccatct tagttcacaa   3240

agtcaggttg atttgccccc agctgtcaaa gcagactacc tgtttccaca tgtaactggt   3300

tatgttctgt aaagttacaa aaatagaaag gttgaatctg tggcggccgg gtacggtagc   3360

tcacgtccta tagtcgcagc actttgggag gccaaggtgg gcagttcacg tgaggtgggg   3420

agttcgagac cagcctgacc aacatggaga aaccccgtct ctactaaaaa tacaaaaata   3480

ttagccgggc gtggtggtgc atgcctgtaa tcccagctac tagggaggct gaggcaggag   3540

aattgcttga acctgggaga cggaggttgc ggtgagctgc agaggcctca cctctaattg   3600

agacacaatt atatattgtt gatatatata tatatatata tacacacaca cacacacact   3660

atgatggata aatgcatgag tttctgtgag agcattggaa aggagtttgt cactcaatag   3720

gtgaagccag gctaagattt aagctgagcc agggaggact tgaaggaatc atgatgagag   3780

agaaggtaag tggctttgcc agcaatgaaa cagctgacat aatggtaacc agtcagagga   3840

gggcataact atgaaactgg acaccttggt tgtcaggtta gaaggatggg gtgtagggtt   3900

ggtaagaaaa gaattcaggg aagagcagcg atcagattat gaagaatttg tcttgagaaa   3960

ttacagagga tttaaaccag aatgttagga atagttattc tagcaagatg aatgtggaaa   4020

gtgttagtgt gcatgtgatg agtcttgaag ctggaaacta ggtaacaggt tcttaaatag   4080

ttcatgtgaa aatcatgaca gactaaggca gtggctgtgg ggctgtccgg gagttctcta   4140

cagaaaacat ctaaaacttg aatgtgcaag tgagtagcta acttccaagc ttcccatttc   4200

tgtataattt aagcatgaaa atgagaacac tgagatttga taggcatgta gaagtcagag   4260

taagcaagag ggcttgagtt catcgatgaa cttcagtaac tatccttgac ttagtattgg   4320

tggaaaccat ttgtgaattt acagactcca aaaacaaaaa gataatttag agtctcaaag   4380

taagatttgg ggagatgtcc attggagaca gaagtggaga gagggagaag ttcatttgtt   4440

gacatattta tgtatggtgc acctactgtg tgccaagcca tgttagagat acagtgggag   4500

caaaaccaga tgtgttttct gccctctgac tccagtggtt gcagaattag cccaggaact   4560

agaattggat ggagtcacac aaaccaagga aggggattgt ttgagggggg cactcagtca   4620

catgtggctg aggccaaaga gaatgaagat atattttaaa attctggatt tggcaaaatt   4680

taggctagtc tttacttttc ataaacctct ctcatgttag agcagcaaag aaaaaccagt   4740

ttgccaagag gtcacgagat tgggcagtga ggaatgggga gtttagttta aaagacaaca   4800

ctagatactt ttggaagttt acctattctg tggttccctt ttattgacta aatggtgccc   4860

ttcattcatg aagcaagtat ctatttagtg actactatgt gtcaaaagct atctaggccc   4920

agaaactttt aagtggaaaa caaaacaaag accctgccct gacagatttc aatcatgtat   4980

atactgtatg tatgtttgtg gaaggtgaca taatagacaa ttgcagatag tgataagtgt   5040

gtaagacaag gataccacga gcgtaataga cagtggggat ggaggaacct ttagaaggtt   5100

ggttaagttg aatgataagg agccattctt ttgtctttac ctgaatgact tatcattcag   5160

ccctttttga gttttgggtt gcttgcagag tttaaccttg cctgtaattg aaacttaatt   5220

ttgtaatagc ataacttcat gtaagaaaag caaagcaata cattacagaa ttattttact   5280

gaagaacttg tttcagagaa agaggctgtt tcacatttat tagcacattt ggattatatt   5340

taggtgtttt attttttttt aaacaaagga gtttggatca taatacaaga gaagcacagg   5400

gcaaagacac tgcataacct caagaactaa gaatggaagg actggccagg cctggtggtg   5460

cacacctgta atcccagcta ctcaggaggc tgaggcgaga gaatcgcttg agcctggggg   5520

gcagaggttg cagtgagctg agagaacggc gggcggcaga gcgagactcc atctcaaaaa   5580

aaaaaaagga taaaggaagg acttaagcaa aatcttcctt gtaagtagaa ggatgttttg   5640

acaagaaaag ttgcaatgga aaaatggttc tcatgtacac gagtatgtag aataagcatc   5700

gtgtgtggat tggattcaga tcaaaacatt gcttttatgt ttgtgtcttt atacggtggg   5760

agtataccct ggtgccccag gatgaagact tgacctgacc catgtatttt tagattactc   5820

acagataaca aaaagtattt tcatcatgat tagttgcgaa aacagtttta tttcaatagg   5880

taaaacgtgc agtcctatgt aatcgtcaga aggtaatctt aattatagct tgggtgtgct   5940

ttaaactgca agctggcagt ggagggcacg attcctctga tttcagcttt ctccttatac   6000

ttttctggag ctgtgagctg caagttaact cagtgggatt aaagtgtaga ctggaggtac   6060

aaaaggtgag gagtgaggag atagggtagt tcttccttgg ctggctggct tcataatccc   6120

tgggccccgc agataattaa atcgactttt tctgtctcag gcatttgtat gacctctttg   6180

gaggttccct gctgggtagt tatccttgta tctgatggac ccatctcaat ttaaaatact   6240

ctgccaggtt cggaggttca tgcttgtcat cccagcactt tgggaggctc agaggtgcca   6300

ttggcttgag cccaagagtt tgagaccagc ctgggcaacc tggtgaaacc tcttctccat   6360

taaaaataca aaaaattagc caggcatggt ggtatgtgcc tgtagtccca gctactcagg   6420

gagctgaggt ggaaggattg cttgagcctg ggaggtcaag gctgcagtga accttgattg   6480

tgccactgca ctccagcctg gatgacaaag accctgtctc aagaaaagtc tgtaattctt   6540

tcctaaccct tagtatccag cctcagtcct gaggttttct ttacctctgg gggctatttt   6600

atgccggctc tctcctgagt gtcacacatc tggtcctcag gaaacattct cacatccctg   6660

gcctgaaaaa aacaatttca gggagatcgc atggcagcag ccctctctgg gctccccagc   6720

taaatggttg tacgaaacac atttcaaagc tctctgaagg gcttccttga agttcctttc   6780

actgggtttc aaagtagaag gtagtaactc ctttgtccaa gaaggctgaa ttgagcactt   6840

aacaattctc caaagaaatt tcttcattgg tctctatcct agaccccttc tgtatccttg   6900

atatggctga ggattctaaa aaatgaccag tcttacatgg gagggctggg atataaaaaa   6960

taaaataata aataatgata aaaactgaaa actgaccacg ttcttggata tgttttcttt   7020

gggttgtgtg tgtgtgtgag acttttgata gttacccaaa gtaggaaaaa tcccattcta   7080

ataaggttat atttatgtag ctctgcaaat aaacatctag caaatgtaaa aagtattttc   7140

tttgccttaa aaatgattaa aattatttga actcctgagg agtgttatat gaataaaatt   7200

agtaagttat ttggaggaaa gttatttttt aaaaagacaa ctggtaaaac agtacaggag   7260

aaaggccagc ttcctcaagt gaggacagtt gtttagaatt gactgaggag cggccgggtg   7320

cggaggctca catctgtaat cccacacgcc ttgggaggct ctgaggcggg tagatcacct   7380

gaggtcagga gtttgagacc agcctggcca acatggcgaa accccgtctc cactaaaaat   7440

acaaaaatta gccaggtgca gtggcacaca cctgtaatcc cagctactcc gaaggctgag   7500

gcaggaggat cacctgagcc caggaagttg agactgcagt gagctgagat tgcaccactg   7560

cactccagcc tcagtgacag cgagactgtc tcaaaaaaag aaaaaagtga ctgaggagga   7620

agaggccagg tggcaaatgg aacagaatca ccaaagggtg aacaggacta aggcaatgta   7680

gtgtatggct cagctacgtc agagtggaaa aggtgttatt agagcagaaa ctatggtccc   7740

tgcgtcacag ggaagcaacc tacagagaag cagcagctcc ccaagagagg agagataaga   7800

agccagaagc ctcagagtga acaattgtcc tattagggat tgctctagag agagaaacct   7860

ctgggaacgt acccctgtga ggcagcacag cacaatgctt ttagaattgt atgagagttg   7920

atatatctcc atttgttttg caaaggcaaa aactaagata cagagattat ctgttaaagt   7980

tatgtatttc tttggtaata aagatgctga cagtgttgct ggaatgcatt tctttaataa   8040

agatattgta caatgaaata ct                                            8062


<210>  2085
<211>  64
<212>  PRT
<213>  Homo sapiens

<400>  2085


Met Cys Arg Arg Arg Glu Arg His Arg Leu Glu Ser Val Ala Ile Arg 
1               5                   10                  15      


Arg Thr Arg Cys Ala Ala Ala Val Ala Leu Arg Pro Thr Thr Phe Arg 
            20                  25                  30          


Ser Arg Pro Val Ala Asn Val Ala Thr Leu Pro Ser Ala Arg Glu Ser 
        35                  40                  45              


Ile Thr Gly Val Pro Arg Leu Lys Asp Glu Ile Pro Pro Glu Asn Thr 
    50                  55                  60                  

<210>  2086
<211>  8041
<212>  DNA
<213>  Homo sapiens

<400>  2086
cagaagcgag atggtgagtt gtgactgtgg tgtttgtgaa tcgcgttcca tcctcgtcct     60

ttgtgcctct ctgtttgctg tgcttggggg gctggcaaga ttccggataa ggggaactgg    120

tgggctggaa agaggcatgc ggtggccctc aagagccaga agaatgactg ctaactggtg    180

cctgggggac ctatcccgcc gtaattgtgg tgctagagcc gcattgtgtc ctttgcctcg    240

gtccaacctt tggagacctt tcacggctct agccttggtt gggagccgag ggaaggagtt    300

tgggaatgtt tggctctgtg taacaatgaa ataattcatt ggtgatgctc tctggccgga    360

gtctgtaaag ataaggtgca tttcagaaca ttgcaactct tgcggagggt tttaggtaac    420

gtgaaatgcg ggtagtggtc tctgacttgg cattcgtgga aagaggcttc tcccgcagtt    480

tcgatcttta cgattgcctt taaattttat cagtaattgg tttcccggag aactcgagta    540

aatctagaag ttgccaggtt tcagaactat ttattccttt aatgtgcaga cgaagggaac    600

gtcatcgttt ggaaagcgtc gcaataagac gcacacgttg tgccgccgct gtggctctaa    660

ggcctaccac cttcagaagt cgacctgtgg caaatgtggc taccctgcca agcgcaagag    720

aaagtgcatg gattccgtga aggaacaaca cctaaaccca agagggcagc tgttgcagca    780

tccagttcat cttaagaatg tcaacgatta gtcatgcaat aaatgttctg gttttaaaaa    840

atacatatct ggttttggta aggtattttt aatcaattag gcttgtagta tcagtgaaat    900

actgtaggtt tagggactgg gctagcttca tatcagattt acttgttaag tgactgtttt    960

ggaatgttta cttttggact gggtttgtaa cacggttaaa ggcaatgaga aacaagcaga   1020

attccaggag tccttgaagc agagggcact ggaagacaat atagcagatt aaaatagcac   1080

agctcatgtg gcataggtgg gtattttaga tgtttgagta aatttgaaag agtatgatgt   1140

ttaaattacc tttagcaaca tgttcatctg ctatgctgtc atgactaggg ggatgattat   1200

tagtcacata gagcttggga gtaccactgg aaacgtatgg gtaggagttt aggtggcttc   1260

tgtttttcaa aagatgatct tatcctagta tctgtaatgc tcacttggca cacctgactt   1320

gtgggctgtg tgtaaggtgg ctagctaagt gaaaaaagcc tgctaggtgt gagtcaactt   1380

aagaatatgt aaataggttt gagaaaaagt agggcttggg tgcaagtaaa gattgagcag   1440

gaaataaagg aaaatcaagt ataatccctg agatttgtag actaaaggca atgatgtggg   1500

actacttggt cgaatttttt tagccctcaa cttggtaatt gggtgtttct gtgttaaagc   1560

actgaaactt gctgtcgtgc cttcctagtt ttcgtggttt attgacaggg ttgggggttt   1620

tttttgtttt tttaaaatga agggacaaag tcaactggac tgctgagtga gagggcaggg   1680

gcagttgaag ggaacatgaa ttgctggaac agctacataa aatagtgatg tagccaagtc   1740

atgctattta aattataatt ctccactgtg tttagaataa catctgaggt tcttaacctg   1800

gccttggaag ggtatcactt ttacttgtaa cctggaatgg ctttataatg tgctagctaa   1860

ttgctactct catcttgtat tttaactcct aatttaccct tcaggtctca gcttcagaac   1920

attcacttat aaagaaaccc tgctgattaa atctctcttg ggcttcctcc cgaaatgtga   1980

gactatactt taaagatgta tggttagagt ccaattgcca ttgcctttct tgtttacaga   2040

tagtgcaatg gcgcaatcct ggctcactgc agcctctaat tcctgggctc aagtcaagtg   2100

gttctcctgc ctcagccttc tgagtagctg ggactacaga tgcacaccac cacacctggc   2160

taatttttgt gttttttgta gagatggaga ttcactcgac taattctttt tgtattctta   2220

gtagagactg ggtttcaaca tgttgaccag gctggtctcg aactcgacct cgtgatccgc   2280

cgcctcggcc tcccaaagtg ctaggattac aggcgtgagc caccactccc ggctgtcatc   2340

atcaaatttt caagtgaaga tagtctgttg aagattgaac aatgaccttg aaagacagct   2400

gagttgctgt gggtataatg taaagctggt gaagtttggc cagtttgggc ttcagaagtc   2460

taagtctagt gaaggtaccc tgacccccat ataaacaacc cttgaggccg gtgtggtggc   2520

tcacggctgt aatcctggca ctttgggagg ccgaggtggg cggatcacaa ggtcaagaga   2580

tcgagatcac cctggcccac atggtgagac cccaactcta ctaaaaatac aaaaattagc   2640

tgggtgtggt ggcatgtgcc tgtagtctta gctacttgag aggctgaggc aggagaatcg   2700

cttgaacctg ggaggcagag gttgcagtga gctgagatca tgccactgtg ctccagcctg   2760

gtggcacagt gagactccac ctcaaaaaaa aaaaaaaatc cttgaactaa tgactcaaat   2820

tttcaaatga aacaaaataa gcagtggatc ttgcattgga gatggagtta aactatgttg   2880

cccaggctgg tcttggactc ctggtttcaa gtgatcctct catcttggcc tcccaaagtg   2940

ctgggattac agggacgagc caccacaccc cacctattgt ctatatttct atctttaaca   3000

gcacttcagt cctgccttaa gttatagtta tgtatagata cccattatac tttaaatttt   3060

tcagcagaaa ttatgctttt atcttctctg cagtgttata tgttggtgtg caaaaatgtt   3120

aaatttattt ttcctaagta ccccatctgc ttttcaactc tgtcctctgc ctgaaaagcc   3180

tccctccagc ccctacttcc ctcccatctt agttcacaaa gtcaggttga tttgccccca   3240

gctgtcaaag cagactacct gtttccacat gtaactggtt atgttctgta aagttacaaa   3300

aatagaaagg ttgaatctgt ggcggccggg tacggtagct cacgtcctat agtcgcagca   3360

ctttgggagg ccaaggtggg cagttcacgt gaggtgggga gttcgagacc agcctgacca   3420

acatggagaa accccgtctc tactaaaaat acaaaaatat tagccgggcg tggtggtgca   3480

tgcctgtaat cccagctact agggaggctg aggcaggaga attgcttgaa cctgggagac   3540

ggaggttgcg gtgagctgca gaggcctcac ctctaattga gacacaatta tatattgttg   3600

atatatatat atatatatat acacacacac acacacacta tgatggataa atgcatgagt   3660

ttctgtgaga gcattggaaa ggagtttgtc actcaatagg tgaagccagg ctaagattta   3720

agctgagcca gggaggactt gaaggaatca tgatgagaga gaaggtaagt ggctttgcca   3780

gcaatgaaac agctgacata atggtaacca gtcagaggag ggcataacta tgaaactgga   3840

caccttggtt gtcaggttag aaggatgggg tgtagggttg gtaagaaaag aattcaggga   3900

agagcagcga tcagattatg aagaatttgt cttgagaaat tacagaggat ttaaaccaga   3960

atgttaggaa tagttattct agcaagatga atgtggaaag tgttagtgtg catgtgatga   4020

gtcttgaagc tggaaactag gtaacaggtt cttaaatagt tcatgtgaaa atcatgacag   4080

actaaggcag tggctgtggg gctgtccggg agttctctac agaaaacatc taaaacttga   4140

atgtgcaagt gagtagctaa cttccaagct tcccatttct gtataattta agcatgaaaa   4200

tgagaacact gagatttgat aggcatgtag aagtcagagt aagcaagagg gcttgagttc   4260

atcgatgaac ttcagtaact atccttgact tagtattggt ggaaaccatt tgtgaattta   4320

cagactccaa aaacaaaaag ataatttaga gtctcaaagt aagatttggg gagatgtcca   4380

ttggagacag aagtggagag agggagaagt tcatttgttg acatatttat gtatggtgca   4440

cctactgtgt gccaagccat gttagagata cagtgggagc aaaaccagat gtgttttctg   4500

ccctctgact ccagtggttg cagaattagc ccaggaacta gaattggatg gagtcacaca   4560

aaccaaggaa ggggattgtt tgaggggggc actcagtcac atgtggctga ggccaaagag   4620

aatgaagata tattttaaaa ttctggattt ggcaaaattt aggctagtct ttacttttca   4680

taaacctctc tcatgttaga gcagcaaaga aaaaccagtt tgccaagagg tcacgagatt   4740

gggcagtgag gaatggggag tttagtttaa aagacaacac tagatacttt tggaagttta   4800

cctattctgt ggttcccttt tattgactaa atggtgccct tcattcatga agcaagtatc   4860

tatttagtga ctactatgtg tcaaaagcta tctaggccca gaaactttta agtggaaaac   4920

aaaacaaaga ccctgccctg acagatttca atcatgtata tactgtatgt atgtttgtgg   4980

aaggtgacat aatagacaat tgcagatagt gataagtgtg taagacaagg ataccacgag   5040

cgtaatagac agtggggatg gaggaacctt tagaaggttg gttaagttga atgataagga   5100

gccattcttt tgtctttacc tgaatgactt atcattcagc cctttttgag ttttgggttg   5160

cttgcagagt ttaaccttgc ctgtaattga aacttaattt tgtaatagca taacttcatg   5220

taagaaaagc aaagcaatac attacagaat tattttactg aagaacttgt ttcagagaaa   5280

gaggctgttt cacatttatt agcacatttg gattatattt aggtgtttta ttttttttta   5340

aacaaaggag tttggatcat aatacaagag aagcacaggg caaagacact gcataacctc   5400

aagaactaag aatggaagga ctggccaggc ctggtggtgc acacctgtaa tcccagctac   5460

tcaggaggct gaggcgagag aatcgcttga gcctgggggg cagaggttgc agtgagctga   5520

gagaacggcg ggcggcagag cgagactcca tctcaaaaaa aaaaaaggat aaaggaagga   5580

cttaagcaaa atcttccttg taagtagaag gatgttttga caagaaaagt tgcaatggaa   5640

aaatggttct catgtacacg agtatgtaga ataagcatcg tgtgtggatt ggattcagat   5700

caaaacattg cttttatgtt tgtgtcttta tacggtggga gtataccctg gtgccccagg   5760

atgaagactt gacctgaccc atgtattttt agattactca cagataacaa aaagtatttt   5820

catcatgatt agttgcgaaa acagttttat ttcaataggt aaaacgtgca gtcctatgta   5880

atcgtcagaa ggtaatctta attatagctt gggtgtgctt taaactgcaa gctggcagtg   5940

gagggcacga ttcctctgat ttcagctttc tccttatact tttctggagc tgtgagctgc   6000

aagttaactc agtgggatta aagtgtagac tggaggtaca aaaggtgagg agtgaggaga   6060

tagggtagtt cttccttggc tggctggctt cataatccct gggccccgca gataattaaa   6120

tcgacttttt ctgtctcagg catttgtatg acctctttgg aggttccctg ctgggtagtt   6180

atccttgtat ctgatggacc catctcaatt taaaatactc tgccaggttc ggaggttcat   6240

gcttgtcatc ccagcacttt gggaggctca gaggtgccat tggcttgagc ccaagagttt   6300

gagaccagcc tgggcaacct ggtgaaacct cttctccatt aaaaatacaa aaaattagcc   6360

aggcatggtg gtatgtgcct gtagtcccag ctactcaggg agctgaggtg gaaggattgc   6420

ttgagcctgg gaggtcaagg ctgcagtgaa ccttgattgt gccactgcac tccagcctgg   6480

atgacaaaga ccctgtctca agaaaagtct gtaattcttt cctaaccctt agtatccagc   6540

ctcagtcctg aggttttctt tacctctggg ggctatttta tgccggctct ctcctgagtg   6600

tcacacatct ggtcctcagg aaacattctc acatccctgg cctgaaaaaa acaatttcag   6660

ggagatcgca tggcagcagc cctctctggg ctccccagct aaatggttgt acgaaacaca   6720

tttcaaagct ctctgaaggg cttccttgaa gttcctttca ctgggtttca aagtagaagg   6780

tagtaactcc tttgtccaag aaggctgaat tgagcactta acaattctcc aaagaaattt   6840

cttcattggt ctctatccta gaccccttct gtatccttga tatggctgag gattctaaaa   6900

aatgaccagt cttacatggg agggctggga tataaaaaat aaaataataa ataatgataa   6960

aaactgaaaa ctgaccacgt tcttggatat gttttctttg ggttgtgtgt gtgtgtgaga   7020

cttttgatag ttacccaaag taggaaaaat cccattctaa taaggttata tttatgtagc   7080

tctgcaaata aacatctagc aaatgtaaaa agtattttct ttgccttaaa aatgattaaa   7140

attatttgaa ctcctgagga gtgttatatg aataaaatta gtaagttatt tggaggaaag   7200

ttatttttta aaaagacaac tggtaaaaca gtacaggaga aaggccagct tcctcaagtg   7260

aggacagttg tttagaattg actgaggagc ggccgggtgc ggaggctcac atctgtaatc   7320

ccacacgcct tgggaggctc tgaggcgggt agatcacctg aggtcaggag tttgagacca   7380

gcctggccaa catggcgaaa ccccgtctcc actaaaaata caaaaattag ccaggtgcag   7440

tggcacacac ctgtaatccc agctactccg aaggctgagg caggaggatc acctgagccc   7500

aggaagttga gactgcagtg agctgagatt gcaccactgc actccagcct cagtgacagc   7560

gagactgtct caaaaaaaga aaaaagtgac tgaggaggaa gaggccaggt ggcaaatgga   7620

acagaatcac caaagggtga acaggactaa ggcaatgtag tgtatggctc agctacgtca   7680

gagtggaaaa ggtgttatta gagcagaaac tatggtccct gcgtcacagg gaagcaacct   7740

acagagaagc agcagctccc caagagagga gagataagaa gccagaagcc tcagagtgaa   7800

caattgtcct attagggatt gctctagaga gagaaacctc tgggaacgta cccctgtgag   7860

gcagcacagc acaatgcttt tagaattgta tgagagttga tatatctcca tttgttttgc   7920

aaaggcaaaa actaagatac agagattatc tgttaaagtt atgtatttct ttggtaataa   7980

agatgctgac agtgttgctg gaatgcattt ctttaataaa gatattgtac aatgaaatac   8040

t                                                                   8041


<210>  2087
<211>  52
<212>  PRT
<213>  Homo sapiens

<400>  2087


Met Cys Arg Arg Arg Glu Arg His Arg Leu Glu Ser Val Ala Ile Arg 
1               5                   10                  15      


Arg Thr Arg Cys Ala Ala Ala Val Ala Leu Arg Pro Thr Thr Phe Arg 
            20                  25                  30          


Ser Arg Pro Val Ala Asn Val Ala Thr Leu Pro Ser Ala Arg Glu Ser 
        35                  40                  45              


Ala Trp Ile Pro 
    50          

<210>  2088
<211>  6133
<212>  DNA
<213>  Homo sapiens

<400>  2088
cagaagcgag atggtgagtt gtgactgtgg tgtttgtgaa tcgcgttcca tcctcgtcct     60

ttgtgcctct ctgtttgctg tgcttggggg gctggcaaga ttccggataa ggggaactgg    120

tgggctggaa agaggcatgc ggtggccctc aagagccaga agaatgactg ctaactggtg    180

cctgggggac ctatcccgcc gtaattgtgg tgctagagcc gcattgtgtc ctttgcctcg    240

gtccaacctt tggagacctt tcacggctct agccttggtt gggagccgag ggaaggagtt    300

tgggaatgtt tggctctgtg taacaatgaa ataattcatt ggtgatgctc tctggccgga    360

gtctgtaaag ataaggtgca tttcagaaca ttgcaactct tgcggagggt tttaggtaac    420

gtgaaatgcg ggtagtggtc tctgacttgg cattcgtgga aagaggcttc tcccgcagtt    480

tcgatcttta cgattgcctt taaattttat cagtaattgg tttcccggag aactcgagta    540

aatctagaag ttgccaggtt tcagaactat ttattccttt aatgtgcaga cgaagggaac    600

gtcatcgttt ggaaagcgtc gcaataagac gcacacgttg tgccgccgct gtggctctaa    660

ggcctaccac cttcagaagt cgacctgtgg caaatgtggc taccctgcca agcgcaagag    720

aaagtataac tggagtgcca aggctaaaag acgaaatacc accggaactg gtcgaatgag    780

gcaggagaat cgcttgaacc tgggaggcag aggttgcagt gagctgagat catgccactg    840

tgctccagcc tggtggcaca gtgagactcc acctcaaaaa aaaaaaaaaa tccttgaact    900

aatgactcaa attttcaaat gaaacaaaat aagcagtgga tcttgcattg gagatggagt    960

taaactatgt tgcccaggct ggtcttggac tcctggtttc aagtgatcct ctcatcttgg   1020

cctcccaaag tgctgggatt acagggacga gccaccacac cccacctatt gtctatattt   1080

ctatctttaa cagcacttca gtcctgcctt aagttatagt tatgtataga tacccattat   1140

actttaaatt tttcagcaga aattatgctt ttatcttctc tgcagtgtta tatgttggtg   1200

tgcaaaaatg ttaaatttat ttttcctaag taccccatct gcttttcaac tctgtcctct   1260

gcctgaaaag cctccctcca gcccctactt ccctcccatc ttagttcaca aagtcaggtt   1320

gatttgcccc cagctgtcaa agcagactac ctgtttccac atgtaactgg ttatgttctg   1380

taaagttaca aaaatagaaa ggttgaatct gtggcggccg ggtacggtag ctcacgtcct   1440

atagtcgcag cactttggga ggccaaggtg ggcagttcac gtgaggtggg gagttcgaga   1500

ccagcctgac caacatggag aaaccccgtc tctactaaaa atacaaaaat attagccggg   1560

cgtggtggtg catgcctgta atcccagcta ctagggaggc tgaggcagga gaattgcttg   1620

aacctgggag acggaggttg cggtgagctg cagaggcctc acctctaatt gagacacaat   1680

tatatattgt tgatatatat atatatatat atacacacac acacacacac tatgatggat   1740

aaatgcatga gtttctgtga gagcattgga aaggagtttg tcactcaata ggtgaagcca   1800

ggctaagatt taagctgagc cagggaggac ttgaaggaat catgatgaga gagaaggtaa   1860

gtggctttgc cagcaatgaa acagctgaca taatggtaac cagtcagagg agggcataac   1920

tatgaaactg gacaccttgg ttgtcaggtt agaaggatgg ggtgtagggt tggtaagaaa   1980

agaattcagg gaagagcagc gatcagatta tgaagaattt gtcttgagaa attacagagg   2040

atttaaacca gaatgttagg aatagttatt ctagcaagat gaatgtggaa agtgttagtg   2100

tgcatgtgat gagtcttgaa gctggaaact aggtaacagg ttcttaaata gttcatgtga   2160

aaatcatgac agactaaggc agtggctgtg gggctgtccg ggagttctct acagaaaaca   2220

tctaaaactt gaatgtgcaa gtgagtagct aacttccaag cttcccattt ctgtataatt   2280

taagcatgaa aatgagaaca ctgagatttg ataggcatgt agaagtcaga gtaagcaaga   2340

gggcttgagt tcatcgatga acttcagtaa ctatccttga cttagtattg gtggaaacca   2400

tttgtgaatt tacagactcc aaaaacaaaa agataattta gagtctcaaa gtaagatttg   2460

gggagatgtc cattggagac agaagtggag agagggagaa gttcatttgt tgacatattt   2520

atgtatggtg cacctactgt gtgccaagcc atgttagaga tacagtggga gcaaaaccag   2580

atgtgttttc tgccctctga ctccagtggt tgcagaatta gcccaggaac tagaattgga   2640

tggagtcaca caaaccaagg aaggggattg tttgaggggg gcactcagtc acatgtggct   2700

gaggccaaag agaatgaaga tatattttaa aattctggat ttggcaaaat ttaggctagt   2760

ctttactttt cataaacctc tctcatgtta gagcagcaaa gaaaaaccag tttgccaaga   2820

ggtcacgaga ttgggcagtg aggaatgggg agtttagttt aaaagacaac actagatact   2880

tttggaagtt tacctattct gtggttccct tttattgact aaatggtgcc cttcattcat   2940

gaagcaagta tctatttagt gactactatg tgtcaaaagc tatctaggcc cagaaacttt   3000

taagtggaaa acaaaacaaa gaccctgccc tgacagattt caatcatgta tatactgtat   3060

gtatgtttgt ggaaggtgac ataatagaca attgcagata gtgataagtg tgtaagacaa   3120

ggataccacg agcgtaatag acagtgggga tggaggaacc tttagaaggt tggttaagtt   3180

gaatgataag gagccattct tttgtcttta cctgaatgac ttatcattca gccctttttg   3240

agttttgggt tgcttgcaga gtttaacctt gcctgtaatt gaaacttaat tttgtaatag   3300

cataacttca tgtaagaaaa gcaaagcaat acattacaga attattttac tgaagaactt   3360

gtttcagaga aagaggctgt ttcacattta ttagcacatt tggattatat ttaggtgttt   3420

tatttttttt taaacaaagg agtttggatc ataatacaag agaagcacag ggcaaagaca   3480

ctgcataacc tcaagaacta agaatggaag gactggccag gcctggtggt gcacacctgt   3540

aatcccagct actcaggagg ctgaggcgag agaatcgctt gagcctgggg ggcagaggtt   3600

gcagtgagct gagagaacgg cgggcggcag agcgagactc catctcaaaa aaaaaaaagg   3660

ataaaggaag gacttaagca aaatcttcct tgtaagtaga aggatgtttt gacaagaaaa   3720

gttgcaatgg aaaaatggtt ctcatgtaca cgagtatgta gaataagcat cgtgtgtgga   3780

ttggattcag atcaaaacat tgcttttatg tttgtgtctt tatacggtgg gagtataccc   3840

tggtgcccca ggatgaagac ttgacctgac ccatgtattt ttagattact cacagataac   3900

aaaaagtatt ttcatcatga ttagttgcga aaacagtttt atttcaatag gtaaaacgtg   3960

cagtcctatg taatcgtcag aaggtaatct taattatagc ttgggtgtgc tttaaactgc   4020

aagctggcag tggagggcac gattcctctg atttcagctt tctccttata cttttctgga   4080

gctgtgagct gcaagttaac tcagtgggat taaagtgtag actggaggta caaaaggtga   4140

ggagtgagga gatagggtag ttcttccttg gctggctggc ttcataatcc ctgggccccg   4200

cagataatta aatcgacttt ttctgtctca ggcatttgta tgacctcttt ggaggttccc   4260

tgctgggtag ttatccttgt atctgatgga cccatctcaa tttaaaatac tctgccaggt   4320

tcggaggttc atgcttgtca tcccagcact ttgggaggct cagaggtgcc attggcttga   4380

gcccaagagt ttgagaccag cctgggcaac ctggtgaaac ctcttctcca ttaaaaatac   4440

aaaaaattag ccaggcatgg tggtatgtgc ctgtagtccc agctactcag ggagctgagg   4500

tggaaggatt gcttgagcct gggaggtcaa ggctgcagtg aaccttgatt gtgccactgc   4560

actccagcct ggatgacaaa gaccctgtct caagaaaagt ctgtaattct ttcctaaccc   4620

ttagtatcca gcctcagtcc tgaggttttc tttacctctg ggggctattt tatgccggct   4680

ctctcctgag tgtcacacat ctggtcctca ggaaacattc tcacatccct ggcctgaaaa   4740

aaacaatttc agggagatcg catggcagca gccctctctg ggctccccag ctaaatggtt   4800

gtacgaaaca catttcaaag ctctctgaag ggcttccttg aagttccttt cactgggttt   4860

caaagtagaa ggtagtaact cctttgtcca agaaggctga attgagcact taacaattct   4920

ccaaagaaat ttcttcattg gtctctatcc tagacccctt ctgtatcctt gatatggctg   4980

aggattctaa aaaatgacca gtcttacatg ggagggctgg gatataaaaa ataaaataat   5040

aaataatgat aaaaactgaa aactgaccac gttcttggat atgttttctt tgggttgtgt   5100

gtgtgtgtga gacttttgat agttacccaa agtaggaaaa atcccattct aataaggtta   5160

tatttatgta gctctgcaaa taaacatcta gcaaatgtaa aaagtatttt ctttgcctta   5220

aaaatgatta aaattatttg aactcctgag gagtgttata tgaataaaat tagtaagtta   5280

tttggaggaa agttattttt taaaaagaca actggtaaaa cagtacagga gaaaggccag   5340

cttcctcaag tgaggacagt tgtttagaat tgactgagga gcggccgggt gcggaggctc   5400

acatctgtaa tcccacacgc cttgggaggc tctgaggcgg gtagatcacc tgaggtcagg   5460

agtttgagac cagcctggcc aacatggcga aaccccgtct ccactaaaaa tacaaaaatt   5520

agccaggtgc agtggcacac acctgtaatc ccagctactc cgaaggctga ggcaggagga   5580

tcacctgagc ccaggaagtt gagactgcag tgagctgaga ttgcaccact gcactccagc   5640

ctcagtgaca gcgagactgt ctcaaaaaaa gaaaaaagtg actgaggagg aagaggccag   5700

gtggcaaatg gaacagaatc accaaagggt gaacaggact aaggcaatgt agtgtatggc   5760

tcagctacgt cagagtggaa aaggtgttat tagagcagaa actatggtcc ctgcgtcaca   5820

gggaagcaac ctacagagaa gcagcagctc cccaagagag gagagataag aagccagaag   5880

cctcagagtg aacaattgtc ctattaggga ttgctctaga gagagaaacc tctgggaacg   5940

tacccctgtg aggcagcaca gcacaatgct tttagaattg tatgagagtt gatatatctc   6000

catttgtttt gcaaaggcaa aaactaagat acagagatta tctgttaaag ttatgtattt   6060

ctttggtaat aaagatgctg acagtgttgc tggaatgcat ttctttaata aagatattgt   6120

acaatgaaat act                                                      6133


<210>  2089
<211>  65
<212>  PRT
<213>  Homo sapiens

<400>  2089


Met Cys Arg Arg Arg Glu Arg His Arg Leu Glu Ser Val Ala Ile Arg 
1               5                   10                  15      


Arg Thr Arg Cys Ala Ala Ala Val Ala Leu Arg Pro Thr Thr Phe Arg 
            20                  25                  30          


Ser Arg Pro Val Ala Asn Val Ala Thr Leu Pro Ser Ala Arg Glu Ser 
        35                  40                  45              


Ile Thr Gly Val Pro Arg Leu Lys Asp Glu Ile Pro Pro Glu Leu Val 
    50                  55                  60                  


Glu 
65  

<210>  2090
<211>  7618
<212>  DNA
<213>  Homo sapiens

<400>  2090
ctgggcggaa gcttctgagc gtgatatagc ggaagtgcct tctcttccgg tctttctggt     60

ctcggccgca gaagcgagat gacgaaggga acgtcatcgt ttggaaagcg tcgcaataag    120

acgcacacgt tgtgccgccg ctgtggctct aaggcctacc accttcagaa gtcgacctgt    180

ggcaaatgtg gctaccctgc caagcgcaag agaaagtata actggagtgc caaggctaaa    240

agacgaaata ccaccggaac tggtcgaatg aggcacctaa aaattgtata ccgcagattc    300

aggcatggat tccgtgaagg aacaacacct aaacccaaga gggcagctgt tgcagcatcc    360

agttcatctt aagaatgtca acgattagtc atgcaataaa tgttctggtt ttaaaaaata    420

catatctggt tttggtaagg tatttttaat caattaggct tgtagtatca gtgaaatact    480

gtaggtttag ggactgggct agcttcatat cagatttact tgttaagtga ctgttttgga    540

atgtttactt ttggactggg tttgtaacac ggttaaaggc aatgagaaac aagcagaatt    600

ccaggagtcc ttgaagcaga gggcactgga agacaatata gcagattaaa atagcacagc    660

tcatgtggca taggtgggta ttttagatgt ttgagtaaat ttgaaagagt atgatgttta    720

aattaccttt agcaacatgt tcatctgcta tgctgtcatg actaggggga tgattattag    780

tcacatagag cttgggagta ccactggaaa cgtatgggta ggagtttagg tggcttctgt    840

ttttcaaaag atgatcttat cctagtatct gtaatgctca cttggcacac ctgacttgtg    900

ggctgtgtgt aaggtggcta gctaagtgaa aaaagcctgc taggtgtgag tcaacttaag    960

aatatgtaaa taggtttgag aaaaagtagg gcttgggtgc aagtaaagat tgagcaggaa   1020

ataaaggaaa atcaagtata atccctgaga tttgtagact aaaggcaatg atgtgggact   1080

acttggtcga atttttttag ccctcaactt ggtaattggg tgtttctgtg ttaaagcact   1140

gaaacttgct gtcgtgcctt cctagttttc gtggtttatt gacagggttg ggggtttttt   1200

ttgttttttt aaaatgaagg gacaaagtca actggactgc tgagtgagag ggcaggggca   1260

gttgaaggga acatgaattg ctggaacagc tacataaaat agtgatgtag ccaagtcatg   1320

ctatttaaat tataattctc cactgtgttt agaataacat ctgaggttct taacctggcc   1380

ttggaagggt atcactttta cttgtaacct ggaatggctt tataatgtgc tagctaattg   1440

ctactctcat cttgtatttt aactcctaat ttacccttca ggtctcagct tcagaacatt   1500

cacttataaa gaaaccctgc tgattaaatc tctcttgggc ttcctcccga aatgtgagac   1560

tatactttaa agatgtatgg ttagagtcca attgccattg cctttcttgt ttacagatag   1620

tgcaatggcg caatcctggc tcactgcagc ctctaattcc tgggctcaag tcaagtggtt   1680

ctcctgcctc agccttctga gtagctggga ctacagatgc acaccaccac acctggctaa   1740

tttttgtgtt ttttgtagag atggagattc actcgactaa ttctttttgt attcttagta   1800

gagactgggt ttcaacatgt tgaccaggct ggtctcgaac tcgacctcgt gatccgccgc   1860

ctcggcctcc caaagtgcta ggattacagg cgtgagccac cactcccggc tgtcatcatc   1920

aaattttcaa gtgaagatag tctgttgaag attgaacaat gaccttgaaa gacagctgag   1980

ttgctgtggg tataatgtaa agctggtgaa gtttggccag tttgggcttc agaagtctaa   2040

gtctagtgaa ggtaccctga cccccatata aacaaccctt gaggccggtg tggtggctca   2100

cggctgtaat cctggcactt tgggaggccg aggtgggcgg atcacaaggt caagagatcg   2160

agatcaccct ggcccacatg gtgagacccc aactctacta aaaatacaaa aattagctgg   2220

gtgtggtggc atgtgcctgt agtcttagct acttgagagg ctgaggcagg agaatcgctt   2280

gaacctggga ggcagaggtt gcagtgagct gagatcatgc cactgtgctc cagcctggtg   2340

gcacagtgag actccacctc aaaaaaaaaa aaaaatcctt gaactaatga ctcaaatttt   2400

caaatgaaac aaaataagca gtggatcttg cattggagat ggagttaaac tatgttgccc   2460

aggctggtct tggactcctg gtttcaagtg atcctctcat cttggcctcc caaagtgctg   2520

ggattacagg gacgagccac cacaccccac ctattgtcta tatttctatc tttaacagca   2580

cttcagtcct gccttaagtt atagttatgt atagataccc attatacttt aaatttttca   2640

gcagaaatta tgcttttatc ttctctgcag tgttatatgt tggtgtgcaa aaatgttaaa   2700

tttatttttc ctaagtaccc catctgcttt tcaactctgt cctctgcctg aaaagcctcc   2760

ctccagcccc tacttccctc ccatcttagt tcacaaagtc aggttgattt gcccccagct   2820

gtcaaagcag actacctgtt tccacatgta actggttatg ttctgtaaag ttacaaaaat   2880

agaaaggttg aatctgtggc ggccgggtac ggtagctcac gtcctatagt cgcagcactt   2940

tgggaggcca aggtgggcag ttcacgtgag gtggggagtt cgagaccagc ctgaccaaca   3000

tggagaaacc ccgtctctac taaaaataca aaaatattag ccgggcgtgg tggtgcatgc   3060

ctgtaatccc agctactagg gaggctgagg caggagaatt gcttgaacct gggagacgga   3120

ggttgcggtg agctgcagag gcctcacctc taattgagac acaattatat attgttgata   3180

tatatatata tatatataca cacacacaca cacactatga tggataaatg catgagtttc   3240

tgtgagagca ttggaaagga gtttgtcact caataggtga agccaggcta agatttaagc   3300

tgagccaggg aggacttgaa ggaatcatga tgagagagaa ggtaagtggc tttgccagca   3360

atgaaacagc tgacataatg gtaaccagtc agaggagggc ataactatga aactggacac   3420

cttggttgtc aggttagaag gatggggtgt agggttggta agaaaagaat tcagggaaga   3480

gcagcgatca gattatgaag aatttgtctt gagaaattac agaggattta aaccagaatg   3540

ttaggaatag ttattctagc aagatgaatg tggaaagtgt tagtgtgcat gtgatgagtc   3600

ttgaagctgg aaactaggta acaggttctt aaatagttca tgtgaaaatc atgacagact   3660

aaggcagtgg ctgtggggct gtccgggagt tctctacaga aaacatctaa aacttgaatg   3720

tgcaagtgag tagctaactt ccaagcttcc catttctgta taatttaagc atgaaaatga   3780

gaacactgag atttgatagg catgtagaag tcagagtaag caagagggct tgagttcatc   3840

gatgaacttc agtaactatc cttgacttag tattggtgga aaccatttgt gaatttacag   3900

actccaaaaa caaaaagata atttagagtc tcaaagtaag atttggggag atgtccattg   3960

gagacagaag tggagagagg gagaagttca tttgttgaca tatttatgta tggtgcacct   4020

actgtgtgcc aagccatgtt agagatacag tgggagcaaa accagatgtg ttttctgccc   4080

tctgactcca gtggttgcag aattagccca ggaactagaa ttggatggag tcacacaaac   4140

caaggaaggg gattgtttga ggggggcact cagtcacatg tggctgaggc caaagagaat   4200

gaagatatat tttaaaattc tggatttggc aaaatttagg ctagtcttta cttttcataa   4260

acctctctca tgttagagca gcaaagaaaa accagtttgc caagaggtca cgagattggg   4320

cagtgaggaa tggggagttt agtttaaaag acaacactag atacttttgg aagtttacct   4380

attctgtggt tcccttttat tgactaaatg gtgcccttca ttcatgaagc aagtatctat   4440

ttagtgacta ctatgtgtca aaagctatct aggcccagaa acttttaagt ggaaaacaaa   4500

acaaagaccc tgccctgaca gatttcaatc atgtatatac tgtatgtatg tttgtggaag   4560

gtgacataat agacaattgc agatagtgat aagtgtgtaa gacaaggata ccacgagcgt   4620

aatagacagt ggggatggag gaacctttag aaggttggtt aagttgaatg ataaggagcc   4680

attcttttgt ctttacctga atgacttatc attcagccct ttttgagttt tgggttgctt   4740

gcagagttta accttgcctg taattgaaac ttaattttgt aatagcataa cttcatgtaa   4800

gaaaagcaaa gcaatacatt acagaattat tttactgaag aacttgtttc agagaaagag   4860

gctgtttcac atttattagc acatttggat tatatttagg tgttttattt ttttttaaac   4920

aaaggagttt ggatcataat acaagagaag cacagggcaa agacactgca taacctcaag   4980

aactaagaat ggaaggactg gccaggcctg gtggtgcaca cctgtaatcc cagctactca   5040

ggaggctgag gcgagagaat cgcttgagcc tggggggcag aggttgcagt gagctgagag   5100

aacggcgggc ggcagagcga gactccatct caaaaaaaaa aaaggataaa ggaaggactt   5160

aagcaaaatc ttccttgtaa gtagaaggat gttttgacaa gaaaagttgc aatggaaaaa   5220

tggttctcat gtacacgagt atgtagaata agcatcgtgt gtggattgga ttcagatcaa   5280

aacattgctt ttatgtttgt gtctttatac ggtgggagta taccctggtg ccccaggatg   5340

aagacttgac ctgacccatg tatttttaga ttactcacag ataacaaaaa gtattttcat   5400

catgattagt tgcgaaaaca gttttatttc aataggtaaa acgtgcagtc ctatgtaatc   5460

gtcagaaggt aatcttaatt atagcttggg tgtgctttaa actgcaagct ggcagtggag   5520

ggcacgattc ctctgatttc agctttctcc ttatactttt ctggagctgt gagctgcaag   5580

ttaactcagt gggattaaag tgtagactgg aggtacaaaa ggtgaggagt gaggagatag   5640

ggtagttctt ccttggctgg ctggcttcat aatccctggg ccccgcagat aattaaatcg   5700

actttttctg tctcaggcat ttgtatgacc tctttggagg ttccctgctg ggtagttatc   5760

cttgtatctg atggacccat ctcaatttaa aatactctgc caggttcgga ggttcatgct   5820

tgtcatccca gcactttggg aggctcagag gtgccattgg cttgagccca agagtttgag   5880

accagcctgg gcaacctggt gaaacctctt ctccattaaa aatacaaaaa attagccagg   5940

catggtggta tgtgcctgta gtcccagcta ctcagggagc tgaggtggaa ggattgcttg   6000

agcctgggag gtcaaggctg cagtgaacct tgattgtgcc actgcactcc agcctggatg   6060

acaaagaccc tgtctcaaga aaagtctgta attctttcct aacccttagt atccagcctc   6120

agtcctgagg ttttctttac ctctgggggc tattttatgc cggctctctc ctgagtgtca   6180

cacatctggt cctcaggaaa cattctcaca tccctggcct gaaaaaaaca atttcaggga   6240

gatcgcatgg cagcagccct ctctgggctc cccagctaaa tggttgtacg aaacacattt   6300

caaagctctc tgaagggctt ccttgaagtt cctttcactg ggtttcaaag tagaaggtag   6360

taactccttt gtccaagaag gctgaattga gcacttaaca attctccaaa gaaatttctt   6420

cattggtctc tatcctagac cccttctgta tccttgatat ggctgaggat tctaaaaaat   6480

gaccagtctt acatgggagg gctgggatat aaaaaataaa ataataaata atgataaaaa   6540

ctgaaaactg accacgttct tggatatgtt ttctttgggt tgtgtgtgtg tgtgagactt   6600

ttgatagtta cccaaagtag gaaaaatccc attctaataa ggttatattt atgtagctct   6660

gcaaataaac atctagcaaa tgtaaaaagt attttctttg ccttaaaaat gattaaaatt   6720

atttgaactc ctgaggagtg ttatatgaat aaaattagta agttatttgg aggaaagtta   6780

ttttttaaaa agacaactgg taaaacagta caggagaaag gccagcttcc tcaagtgagg   6840

acagttgttt agaattgact gaggagcggc cgggtgcgga ggctcacatc tgtaatccca   6900

cacgccttgg gaggctctga ggcgggtaga tcacctgagg tcaggagttt gagaccagcc   6960

tggccaacat ggcgaaaccc cgtctccact aaaaatacaa aaattagcca ggtgcagtgg   7020

cacacacctg taatcccagc tactccgaag gctgaggcag gaggatcacc tgagcccagg   7080

aagttgagac tgcagtgagc tgagattgca ccactgcact ccagcctcag tgacagcgag   7140

actgtctcaa aaaaagaaaa aagtgactga ggaggaagag gccaggtggc aaatggaaca   7200

gaatcaccaa agggtgaaca ggactaaggc aatgtagtgt atggctcagc tacgtcagag   7260

tggaaaaggt gttattagag cagaaactat ggtccctgcg tcacagggaa gcaacctaca   7320

gagaagcagc agctccccaa gagaggagag ataagaagcc agaagcctca gagtgaacaa   7380

ttgtcctatt agggattgct ctagagagag aaacctctgg gaacgtaccc ctgtgaggca   7440

gcacagcaca atgcttttag aattgtatga gagttgatat atctccattt gttttgcaaa   7500

ggcaaaaact aagatacaga gattatctgt taaagttatg tatttctttg gtaataaaga   7560

tgctgacagt gttgctggaa tgcatttctt taataaagat attgtacaat gaaatact     7618


<210>  2091
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  2091


Met Thr Lys Gly Thr Ser Ser Phe Gly Lys Arg Arg Asn Lys Thr His 
1               5                   10                  15      


Thr Leu Cys Arg Arg Cys Gly Ser Lys Ala Tyr His Leu Gln Lys Ser 
            20                  25                  30          


Thr Cys Gly Lys Cys Gly Tyr Pro Ala Lys Arg Lys Arg Lys Tyr Asn 
        35                  40                  45              


Trp Ser Ala Lys Ala Lys Arg Arg Asn Thr Thr Gly Thr Gly Arg Met 
    50                  55                  60                  


Arg His Leu Lys Ile Val Tyr Arg Arg Phe Arg His Gly Phe Arg Glu 
65                  70                  75                  80  


Gly Thr Thr Pro Lys Pro Lys Arg Ala Ala Val Ala Ala Ser Ser Ser 
                85                  90                  95      


Ser 
    

<210>  2092
<211>  3200
<212>  DNA
<213>  Homo sapiens

<400>  2092
ctcttgaccc cacctacact acgacgacgg acgctcgaga acgctgcacc gcgccccgca     60

ggaagtgctt ccctgggcgg aagcttctga gcgtgatata gcggaagtgc cttctcttcc    120

ggtctttctg gtctcggccg cagaagcgag atgacgaagg gaacgtcatc gtttggaaag    180

cgtcgcaata agacgcacac gttgtgccgc cgctgtggct ctaaggccta ccaccttcag    240

aagtcgacct gtggcaaatg tggctaccct gccaagcgca agagaaagta taactggagt    300

gccaaggcta aaagacgaaa taccaccgga actggtcgaa tgaggcacct aaaaattgta    360

taccgcagat tcaggcatgg attccgtgaa ggaacaacac ctaaacccaa gagggcagct    420

gttgcagcat ccagttcatc ttaagaatgt caacgattag tcatgcaata aatgttctgg    480

ttttaaaaaa tacatatctg gttttggagt ttggatcata atacaagaga agcacagggc    540

aaagacactg cataacctca agaactaaga atggaaggac tggccaggcc tggtggtgca    600

cacctgtaat cccagctact caggaggctg aggcgagaga atcgcttgag cctggggggc    660

agaggttgca gtgagctgag agaacggcgg gcggcagagc gagactccat ctcaaaaaaa    720

aaaaaggata aaggaaggac ttaagcaaaa tcttccttgt aagtagaagg atgttttgac    780

aagaaaagtt gcaatggaaa aatggttctc atgtacacga gtatgtagaa taagcatcgt    840

gtgtggattg gattcagatc aaaacattgc ttttatgttt gtgtctttat acggtgggag    900

tataccctgg tgccccagga tgaagacttg acctgaccca tgtattttta gattactcac    960

agataacaaa aagtattttc atcatgatta gttgcgaaaa cagttttatt tcaataggta   1020

aaacgtgcag tcctatgtaa tcgtcagaag gtaatcttaa ttatagcttg ggtgtgcttt   1080

aaactgcaag ctggcagtgg agggcacgat tcctctgatt tcagctttct ccttatactt   1140

ttctggagct gtgagctgca agttaactca gtgggattaa agtgtagact ggaggtacaa   1200

aaggtgagga gtgaggagat agggtagttc ttccttggct ggctggcttc ataatccctg   1260

ggccccgcag ataattaaat cgactttttc tgtctcaggc atttgtatga cctctttgga   1320

ggttccctgc tgggtagtta tccttgtatc tgatggaccc atctcaattt aaaatactct   1380

gccaggttcg gaggttcatg cttgtcatcc cagcactttg ggaggctcag aggtgccatt   1440

ggcttgagcc caagagtttg agaccagcct gggcaacctg gtgaaacctc ttctccatta   1500

aaaatacaaa aaattagcca ggcatggtgg tatgtgcctg tagtcccagc tactcaggga   1560

gctgaggtgg aaggattgct tgagcctggg aggtcaaggc tgcagtgaac cttgattgtg   1620

ccactgcact ccagcctgga tgacaaagac cctgtctcaa gaaaagtctg taattctttc   1680

ctaaccctta gtatccagcc tcagtcctga ggttttcttt acctctgggg gctattttat   1740

gccggctctc tcctgagtgt cacacatctg gtcctcagga aacattctca catccctggc   1800

ctgaaaaaaa caatttcagg gagatcgcat ggcagcagcc ctctctgggc tccccagcta   1860

aatggttgta cgaaacacat ttcaaagctc tctgaagggc ttccttgaag ttcctttcac   1920

tgggtttcaa agtagaaggt agtaactcct ttgtccaaga aggctgaatt gagcacttaa   1980

caattctcca aagaaatttc ttcattggtc tctatcctag accccttctg tatccttgat   2040

atggctgagg attctaaaaa atgaccagtc ttacatggga gggctgggat ataaaaaata   2100

aaataataaa taatgataaa aactgaaaac tgaccacgtt cttggatatg ttttctttgg   2160

gttgtgtgtg tgtgtgagac ttttgatagt tacccaaagt aggaaaaatc ccattctaat   2220

aaggttatat ttatgtagct ctgcaaataa acatctagca aatgtaaaaa gtattttctt   2280

tgccttaaaa atgattaaaa ttatttgaac tcctgaggag tgttatatga ataaaattag   2340

taagttattt ggaggaaagt tattttttaa aaagacaact ggtaaaacag tacaggagaa   2400

aggccagctt cctcaagtga ggacagttgt ttagaattga ctgaggagcg gccgggtgcg   2460

gaggctcaca tctgtaatcc cacacgcctt gggaggctct gaggcgggta gatcacctga   2520

ggtcaggagt ttgagaccag cctggccaac atggcgaaac cccgtctcca ctaaaaatac   2580

aaaaattagc caggtgcagt ggcacacacc tgtaatccca gctactccga aggctgaggc   2640

aggaggatca cctgagccca ggaagttgag actgcagtga gctgagattg caccactgca   2700

ctccagcctc agtgacagcg agactgtctc aaaaaaagaa aaaagtgact gaggaggaag   2760

aggccaggtg gcaaatggaa cagaatcacc aaagggtgaa caggactaag gcaatgtagt   2820

gtatggctca gctacgtcag agtggaaaag gtgttattag agcagaaact atggtccctg   2880

cgtcacaggg aagcaaccta cagagaagca gcagctcccc aagagaggag agataagaag   2940

ccagaagcct cagagtgaac aattgtccta ttagggattg ctctagagag agaaacctct   3000

gggaacgtac ccctgtgagg cagcacagca caatgctttt agaattgtat gagagttgat   3060

atatctccat ttgttttgca aaggcaaaaa ctaagataca gagattatct gttaaagtta   3120

tgtatttctt tggtaataaa gatgctgaca gtgttgctgg aatgcatttc tttaataaag   3180

atattgtaca atgaaatact                                               3200


<210>  2093
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  2093


Met Thr Lys Gly Thr Ser Ser Phe Gly Lys Arg Arg Asn Lys Thr His 
1               5                   10                  15      


Thr Leu Cys Arg Arg Cys Gly Ser Lys Ala Tyr His Leu Gln Lys Ser 
            20                  25                  30          


Thr Cys Gly Lys Cys Gly Tyr Pro Ala Lys Arg Lys Arg Lys Tyr Asn 
        35                  40                  45              


Trp Ser Ala Lys Ala Lys Arg Arg Asn Thr Thr Gly Thr Gly Arg Met 
    50                  55                  60                  


Arg His Leu Lys Ile Val Tyr Arg Arg Phe Arg His Gly Phe Arg Glu 
65                  70                  75                  80  


Gly Thr Thr Pro Lys Pro Lys Arg Ala Ala Val Ala Ala Ser Ser Ser 
                85                  90                  95      


Ser 
    

<210>  2094
<211>  741
<212>  DNA
<213>  Homo sapiens

<400>  2094
cggcagagcg agactccatc tcaaaaaaaa aaaaggataa aggaaggact taagcaaaat     60

cttccttgta agtagaagga tgttttgaca agaaaagttg caatggaaaa atggttctca    120

tgtacacgag tatgtagaat aagcatcgtg tgtggattgg attcagatca aaacattgct    180

tttatgtttg tgtctttata cggtgggagt ataccctggt gccccaggat gaagacttga    240

cctgacccat gtatttttag attactcaca gataacaaaa agtattttca tcatgattag    300

ttgcgaaaac agttttattt caataggtaa aacgtgcagt cctatgtaat cgtcagaagg    360

taatcttaat tatagcttgg gtgtgcttta aactgcaagc tggcagtgga gggcacgatt    420

cctctgattt cagctttctc cttatacttt tctggagctg tgagctgcaa gttaactcag    480

tgggattaaa gtgtagactg gagtgaacaa ttgtcctatt agggattgct ctagagagag    540

aaacctctgg gaacgtaccc ctgtgaggca gcacagcaca atgcttttag aattgtatga    600

gagttgatat atctccattt gttttgcaaa ggcaaaaact aagatacaga gattatctgt    660

taaagttatg tatttctttg gtaataaaga tgctgacagt gttgctggaa tgcatttctt    720

taataaagat attgtacaat g                                              741


<210>  2095
<211>  47
<212>  PRT
<213>  Homo sapiens

<400>  2095


Met Arg Val Asp Ile Ser Pro Phe Val Leu Gln Arg Gln Lys Leu Arg 
1               5                   10                  15      


Tyr Arg Asp Tyr Leu Leu Lys Leu Cys Ile Ser Leu Val Ile Lys Met 
            20                  25                  30          


Leu Thr Val Leu Leu Glu Cys Ile Ser Leu Ile Lys Ile Leu Tyr 
        35                  40                  45          

<210>  2096
<211>  1205
<212>  DNA
<213>  Homo sapiens

<400>  2096
actgggctag cttcatatca gatttacttg ttaagtgact gttttggaat gtttactttt     60

ggactgggtt tgtaacacgg ttaaaggcaa tgagaaacaa gcagaattcc aggagtcctt    120

gaagcagagg gcactggaag acaatatagc agattaaaat agcacagctc atgtggcata    180

ggtgggtatt ttagatgttt gagtaaattt gaaagagtat gatgtttaaa ttacctttag    240

caacatgttc atctgctatg ctgtcatgac tagggggatg attattagtc acatagagct    300

tgggagtacc actggaaacg tatgggtagg agtttaggtg gcttctgttt ttcaaaagat    360

gatcttatcc tagtatctgt aatgctcact tggcacacct gacttgtggg cggatcacaa    420

ggtcaagaga tcgagatcac cctggcccac atggtgagac cccaactcta ctaaaaatac    480

aaaaattagc tgggtgtggt ggcatgtgcc attggcttga gcccaagagt ttgagaccag    540

cctgggcaac ctggtgaaac ctcttctcca ttaaaaatac aaaaaattag ccaggcatgg    600

tggtatgtgc ctgtagtccc agctactcag ggagctgagg tggaaggatt gcttgagcct    660

gggaggtcaa ggctgcagtg aaccttgatt gtgccactgc actccagcct ggatgacaaa    720

gaccctgtct caagaaaagt ctgtaattct ttcctaaccc ttagtatcca gcctcagtcc    780

tgaggttttc tttacctctg ggggctattt tatgccggct ctctcctgag tgtcacacat    840

ctggtcctca ggaaacattc tcacatccct ggcctgaaaa aaacaatttc agggagatcg    900

catggcagca gccctctctg ggctccccag ctaaatggtt gtacgaaaca catttcaaag    960

ctctctgaag ggcttccttg aagttccttt cactgggttt caaagtagaa ggtagtaact   1020

cctttgtcca agaaggctga attgagcact taacaattct ccaaagaaat ttcttcattg   1080

gtctctatcc tagacccctt ctgtatcctt gatatggctg aggattctaa aaaatgacca   1140

gtcttacatg ggagggctgg gatataaaaa ataaaataat aaataatgat aaaaactgaa   1200

aactg                                                               1205


<210>  2097
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  2097


Met Phe Ile Cys Tyr Ala Val Met Thr Arg Gly Met Ile Ile Ser His 
1               5                   10                  15      


Ile Glu Leu Gly Ser Thr Thr Gly Asn Val Trp Val Gly Val 
            20                  25                  30  

<210>  2098
<211>  6973
<212>  DNA
<213>  Homo sapiens

<400>  2098
cagaagcgag atggtgagtt gtgactgtgg tgtttgtgaa tcgcgttcca tcctcgtcct     60

ttgtgcctct ctgtttgctg tgcttggggg gctggcaaga ttccggataa ggggaactgg    120

tgggctggaa agaggcatgc ggtggccctc aagagccaga agaatgactg ctaactggtg    180

cctgggggac ctatcccgcc gtaattgtgg tgctagagcc gcattgtgtc ctttgcctcg    240

gtccaacctt tggagacctt tcacggctct agccttggtt gggagccgag ggaaggagtt    300

tgggaatgtt tggctctgtg taacaatgaa ataattcatt ggtgatgctc tctggccgga    360

gtctgtaaag ataaggtgca tttcagaaca ttgcaactct tgcggagggt tttaggtaac    420

gtgaaatgcg ggtagtggtc tctgacttgg cattcgtgga aagaggcttc tcccgcagtt    480

tcgatcttta cgattgcctt taaattttat cagtaattgg tttcccggag aactcgagta    540

aatctagaag ttgccaggtt tcagaactat ttattccttt aatgtgcaga cgaagggaac    600

gtcatcgttt ggaaagcgtc gcaataagac gcacacgttg tgccgccgct gtggctctaa    660

ggcctaccac cttcagaagt cgacctgtgg caaatgtggc taccctgcca agcgcaagag    720

aaagtgcatg gattccgtga aggaacaaca cctaaaccca agagggcagc tgttgcagca    780

tccagttcat cttaagaatg tcaacgatta gtcatgcaat aaatgttctg gttttaaaaa    840

atacatatct ggttttggta aggtattttt aatcaattag gcttgtagta tcagtgaaat    900

actgtaggtt tagggactgg gctagcttca tatcagattt acttgttaag tgactgtttt    960

ggaatgttta cttttggact gggtttgtaa cacggttaaa ggcaatgaga aacaagcaga   1020

attccaggag tccttgaagc agagggcact ggaagacaat atagcagatt aaaatagcac   1080

agctcatgtg gcataggtgg gtattttaga tgtttgagta aatttgaaag agtatgatgt   1140

ttaaattacc tttagcaaca tgttcatctg ctatgctgtc atgactaggg ggatgattat   1200

tagtcacata gagcttggga gtaccactgg aaacgtatgg gtaggagttt aggtggcttc   1260

tgtttttcaa aagatgatct tatcctagta tctgtaatgc tcacttggca cacctgactt   1320

gtgggctgtg tgtaaggtgg ctagctaagt gaaaaaagcc tgctaggtgt gagtcaactt   1380

aagaatatgt aaataggttt gagaaaaagt agggcttggg tgcaagtaaa gattgagcag   1440

gaaataaagg aaaatcaagt ataatccctg agatttgtag actaaaggca atgatgtggg   1500

actacttggt cgaatttttt tagccctcaa cttggtaatt gggtgtttct gtgttaaagc   1560

actgaaactt gctgtcgtgc cttcctagtt ttcgtggttt attgacaggg ttgggggttt   1620

tttttgtttt tttaaaatga agggacaaag tcaactggac tgctgagtga gagggcaggg   1680

gcagttgaag ggaacatgaa ttgctggaac agctacataa aatagtgatg tagccaagtc   1740

atgctattta aattataatt ctccactgtg tttagaataa catctgaggt tcttaacctg   1800

gccttggaag ggtatcactt ttacttgtaa cctggaatgg ctttataatg tgctagctaa   1860

ttgctactct catcttgtat tttaactcct aatttaccct tcaggtctca gcttcagaac   1920

attcacttat aaagaaaccc tgctgattaa atctctcttg ggcttcctcc cgaaatgtga   1980

gactatactt taaagatgta tggttagagt ccaattgcca ttgcctttct tgtttacaga   2040

tagtgcaatg gcgcaatcct ggctcactgc agcctctaat tcctgggctc aagtcaagtg   2100

gttctcctgc ctcagccttc tgagtagctg ggactacaga tgcacaccac cacacctggc   2160

taatttttgt gttttttgta gagatggaga ttcactcgac taattctttt tgtattctta   2220

gtagagactg ggtttcaaca tgttgaccag gctggtctcg aactcgacct cgtgatccgc   2280

cgcctcggcc tcccaaagtg ctaggattac aggcgtgagc caccactccc ggctgtcatc   2340

atcaaatttt caagtgaaga tagtctgttg aagattgaac aatgaccttg aaagacagct   2400

gagttgctgt gggtataatg taaagctggt gaagtttggc cagtttgggc ttcagaagtc   2460

taagtctagt gaaggtaccc tgacccccat ataaacaacc cttgaggccg gtgtggtggc   2520

tcacggctgt aatcctggca ctttgggagg ccgaggtggg cggatcacaa ggtcaagaga   2580

tcgagatcac cctggcccac atggtgagac cccaactcta ctaaaaatac aaaaattagc   2640

tgggtgtggt ggcatgtgcc tgtagtctta gctacttgag aggctgaggc aggagaatcg   2700

cttgaacctg ggaggcagag gttgcagtga gctgagatca tgccactgtg ctccagcctg   2760

gtggcacagt gagactccac ctcaaaaaaa aaaaaaaatc cttgaactaa tgactcaaat   2820

tttcaaatga aacaaaataa gcagtggatc ttgcattgga gatggagtta aactatgttg   2880

cccaggctgg tcttggactc ctggtttcaa gtgatcctct catcttggcc tcccaaagtg   2940

ctgggattac agggacgagc caccacaccc cacctattgt ctatatttct atctttaaca   3000

gcacttcagt cctgccttaa gttatagtta tgtatagata cccattatac tttaaatttt   3060

tcagcagaaa ttatgctttt atcttctctg cagtgttata tgttggtgtg caaaaatgtt   3120

aaatttattt ttcctaagta ccccatctgc ttttcaactc tgtcctctgc ctgaaaagcc   3180

tccctccagc ccctacttcc ctcccatctt agttcacaaa gtcaggttga tttgccccca   3240

gctgtcaaag cagactacct gtttccacat gtaactggtt atgttctgta aagttacaaa   3300

aatagaaagg ttgaatctgt ggcggccggg tacggtagct cacgtcctat agtcgcagca   3360

ctttgggagg ccaaggtggg cagttcacgt gaggtgggga gttcgagacc agcctgacca   3420

acatggagaa accccgtctc tactaaaaat acaaaaatat tagccgggcg tggtggtgca   3480

tgcctgtaat cccagctact agggaggctg aggcaggaga attgcttgaa cctgggagac   3540

ggaggttgcg gtgagctgca gaggcctcac ctctaattga gacacaatta tatattgttg   3600

atatatatat atatatatat acacacacac acacacacta tgatggataa atgcatgagt   3660

ttctgtgaga gcattggaaa ggagtttgtc actcaatagg tgaagccagg ctaagattta   3720

agctgagcca gggaggactt gaaggaatca tgatgagaga gaaggtaagt ggctttgcca   3780

gcaatgaaac agctgacata atggtaacca gtcagaggag ggcataacta tgaaactgga   3840

caccttggtt gtcaggttag aaggatgggg tgtagggttg gtaagaaaag aattcaggga   3900

agagcagcga tcagattatg aagaatttgt cttgagaaat tacagaggat ttaaaccaga   3960

atgttaggaa tagttattct agcaagatga atgtggaaag tgttagtgtg catgtgatga   4020

gtcttgaagc tggaaactag gtaacaggtt cttaaatagt tcatgtgaaa atcatgacag   4080

actaaggcag tggctgtggg gctgtccggg agttctctac agaaaacatc taaaacttga   4140

atgtgcaagt gagtagctaa cttccaagct tcccatttct gtataattta agcatgaaaa   4200

tgagaacact gagatttgat aggcatgtag aagtcagagt aagcaagagg gcttgagttc   4260

atcgatgaac ttcagtaact atccttgact tagtattggt ggaaaccatt tgtgaattta   4320

cagactccaa aaacaaaaag ataatttaga gtctcaaagt aagatttggg gagatgtcca   4380

ttggagacag aagtggagag agggagaagt tcatttgttg acatatttat gtatggtgca   4440

cctactgtgt gccaagccat gttagagata cagtgggagc aaaaccagat gtgttttctg   4500

ccctctgact ccagtggttg cagaattagc ccaggaacta gaattggatg gagtcacaca   4560

aaccaaggaa ggggattgtt tgaggggggc actcagtcac atgtggctga ggccaaagag   4620

aatgaagata tattttaaaa ttctggattt ggcaaaattt aggctagtct ttacttttca   4680

taaacctctc tcatgttaga gcagcaaaga aaaaccagtt tgccaagagg tcacgagatt   4740

gggcagtgag gaatggggag tttagtttaa aagacaacac tagatacttt tggaagttta   4800

cctattctgt ggttcccttt tattgactaa atggtgccct tcattcatga agcaagtatc   4860

tatttagtga ctactatgtg tcaaaagcta tctaggccca gaaactttta agtggaaaac   4920

aaaacaaaga ccctgccctg acagatttca atcatgtata tactgtatgt atgtttgtgg   4980

aaggtgacat aatagacaat tgcagatagt gataagtgtg taagacaagg ataccacgag   5040

cgtaatagac agtggggatg gaggaacctt tagaaggttg gttaagttga atgataagga   5100

gccattcttt tgtctttacc tgaatgactt atcattcagc cctttttgag ttttgggttg   5160

cttgcagagt ttaaccttgc ctgtaattga aacttaattt tgtaatagca taacttcatg   5220

taagaaaagc aaagcaatac attacagaat tattttactg aagaacttgt ttcagagaaa   5280

gaggctgttt cacatttatt agcacatttg gattatattt aggtgtttta ttttttttta   5340

aacaaaggag tttggatcat aatacaagag aagcacaggg caaagacact gcataacctc   5400

aagaactaag aatggaagga ctggccaggc ctggtggtgc acacctgtaa tcccagctac   5460

tcaggaggct gaggcgagag aatcgcttga gcctgggggg cagaggttgc agtgagctga   5520

gagaacggcg ggcggcagag cgagactcca tctcaaaaaa aaaaaaggat aaaggaagga   5580

cttaagcaaa atcttccttg taagtagaag gatgttttga caagaaaagt tgcaatggaa   5640

aaatggttct catgtacacg agtatgtaga ataagcatcg tgtgtggatt ggattcagat   5700

caaaacattg cttttatgtt tgtgtcttta tacggtggga gtataccctg gtgccccagg   5760

atgaagactt gacctgaccc atgtattttt agattactca cagataacaa aaagtatttt   5820

catcatgatt agttgcgaaa acagttttat ttcaataggt aaaacgtgca gtcctatgta   5880

atcgtcagaa ggtaatctta attatagctt gggtgtgctt taaactgcaa gctggcagtg   5940

gagggcacga ttcctctgat ttcagctttc tccttatact tttctggagc tgtgagctgc   6000

aagttaactc agtgggatta aagtgtagac tggaggtaca aaaggtgagg agtgaggaga   6060

tagggtagtt cttccttggc tggctggctt cataatccct gggccccgca gataattaaa   6120

tcgacttttt ctgtctcagg catttgtatg acctctttgg aggttccctg ctgggtagtt   6180

atccttgtat ctgatggacc catctcaatt taaaatactc tgccaggttc ggaggttcat   6240

gcttgtcatc ccagcacttt gggaggctca gaggtgccat tggcttgagc ccaagagttt   6300

gagaccagcc tgggcaacct ggtgaaacct cttctccatt aaaaatacaa aaaattagcc   6360

aggcatggtg gtatgtgcct gtagtcccag ctactcaggg agctgaggtg gaaggattgc   6420

ttgagcctgg gaggtcaagg ctgcagtgaa ccttgattgt gccactgcac tccagcctgg   6480

atgacaaaga ccctgtctca agaaaagtct gtaattcttt cctaaccctt agtatccagc   6540

ctcagtcctg aggttttctt tacctctggg ggctatttta tgccggctct ctcctgagtg   6600

tcacacatct ggtcctcagg aaacattctc acatccctgg cctgaaaaaa acaatttcag   6660

ggagatcgca tggcagcagc cctctctggg ctccccagct aaatggttgt acgaaacaca   6720

tttcaaagct ctctgaaggg cttccttgaa gttcctttca ctgggtttca aagtagaagg   6780

tagtaactcc tttgtccaag aaggctgaat tgagcactta acaattctcc aaagaaattt   6840

cttcattggt ctctatccta gaccccttct gtatccttga tatggctgag gattctaaaa   6900

aatgaccagt cttacatggg agggctggga tataaaaaat aaaataataa ataatgataa   6960

aaactgaaaa ctg                                                      6973


<210>  2099
<211>  52
<212>  PRT
<213>  Homo sapiens

<400>  2099


Met Cys Arg Arg Arg Glu Arg His Arg Leu Glu Ser Val Ala Ile Arg 
1               5                   10                  15      


Arg Thr Arg Cys Ala Ala Ala Val Ala Leu Arg Pro Thr Thr Phe Arg 
            20                  25                  30          


Ser Arg Pro Val Ala Asn Val Ala Thr Leu Pro Ser Ala Arg Glu Ser 
        35                  40                  45              


Ala Trp Ile Pro 
    50          

<210>  2100
<211>  6994
<212>  DNA
<213>  Homo sapiens

<400>  2100
cagaagcgag atggtgagtt gtgactgtgg tgtttgtgaa tcgcgttcca tcctcgtcct     60

ttgtgcctct ctgtttgctg tgcttggggg gctggcaaga ttccggataa ggggaactgg    120

tgggctggaa agaggcatgc ggtggccctc aagagccaga agaatgactg ctaactggtg    180

cctgggggac ctatcccgcc gtaattgtgg tgctagagcc gcattgtgtc ctttgcctcg    240

gtccaacctt tggagacctt tcacggctct agccttggtt gggagccgag ggaaggagtt    300

tgggaatgtt tggctctgtg taacaatgaa ataattcatt ggtgatgctc tctggccgga    360

gtctgtaaag ataaggtgca tttcagaaca ttgcaactct tgcggagggt tttaggtaac    420

gtgaaatgcg ggtagtggtc tctgacttgg cattcgtgga aagaggcttc tcccgcagtt    480

tcgatcttta cgattgcctt taaattttat cagtaattgg tttcccggag aactcgagta    540

aatctagaag ttgccaggtt tcagaactat ttattccttt aatgtgcaga cgaagggaac    600

gtcatcgttt ggaaagcgtc gcaataagac gcacacgttg tgccgccgct gtggctctaa    660

ggcctaccac cttcagaagt cgacctgtgg caaatgtggc taccctgcca agcgcaagag    720

aaagtataac tggagtgcca aggctaaaag acgaaatacc accggaaaac acctaaaccc    780

aagagggcag ctgttgcagc atccagttca tcttaagaat gtcaacgatt agtcatgcaa    840

taaatgttct ggttttaaaa aatacatatc tggttttggt aaggtatttt taatcaatta    900

ggcttgtagt atcagtgaaa tactgtaggt ttagggactg ggctagcttc atatcagatt    960

tacttgttaa gtgactgttt tggaatgttt acttttggac tgggtttgta acacggttaa   1020

aggcaatgag aaacaagcag aattccagga gtccttgaag cagagggcac tggaagacaa   1080

tatagcagat taaaatagca cagctcatgt ggcataggtg ggtattttag atgtttgagt   1140

aaatttgaaa gagtatgatg tttaaattac ctttagcaac atgttcatct gctatgctgt   1200

catgactagg gggatgatta ttagtcacat agagcttggg agtaccactg gaaacgtatg   1260

ggtaggagtt taggtggctt ctgtttttca aaagatgatc ttatcctagt atctgtaatg   1320

ctcacttggc acacctgact tgtgggctgt gtgtaaggtg gctagctaag tgaaaaaagc   1380

ctgctaggtg tgagtcaact taagaatatg taaataggtt tgagaaaaag tagggcttgg   1440

gtgcaagtaa agattgagca ggaaataaag gaaaatcaag tataatccct gagatttgta   1500

gactaaaggc aatgatgtgg gactacttgg tcgaattttt ttagccctca acttggtaat   1560

tgggtgtttc tgtgttaaag cactgaaact tgctgtcgtg ccttcctagt tttcgtggtt   1620

tattgacagg gttgggggtt ttttttgttt ttttaaaatg aagggacaaa gtcaactgga   1680

ctgctgagtg agagggcagg ggcagttgaa gggaacatga attgctggaa cagctacata   1740

aaatagtgat gtagccaagt catgctattt aaattataat tctccactgt gtttagaata   1800

acatctgagg ttcttaacct ggccttggaa gggtatcact tttacttgta acctggaatg   1860

gctttataat gtgctagcta attgctactc tcatcttgta ttttaactcc taatttaccc   1920

ttcaggtctc agcttcagaa cattcactta taaagaaacc ctgctgatta aatctctctt   1980

gggcttcctc ccgaaatgtg agactatact ttaaagatgt atggttagag tccaattgcc   2040

attgcctttc ttgtttacag atagtgcaat ggcgcaatcc tggctcactg cagcctctaa   2100

ttcctgggct caagtcaagt ggttctcctg cctcagcctt ctgagtagct gggactacag   2160

atgcacacca ccacacctgg ctaatttttg tgttttttgt agagatggag attcactcga   2220

ctaattcttt ttgtattctt agtagagact gggtttcaac atgttgacca ggctggtctc   2280

gaactcgacc tcgtgatccg ccgcctcggc ctcccaaagt gctaggatta caggcgtgag   2340

ccaccactcc cggctgtcat catcaaattt tcaagtgaag atagtctgtt gaagattgaa   2400

caatgacctt gaaagacagc tgagttgctg tgggtataat gtaaagctgg tgaagtttgg   2460

ccagtttggg cttcagaagt ctaagtctag tgaaggtacc ctgaccccca tataaacaac   2520

ccttgaggcc ggtgtggtgg ctcacggctg taatcctggc actttgggag gccgaggtgg   2580

gcggatcaca aggtcaagag atcgagatca ccctggccca catggtgaga ccccaactct   2640

actaaaaata caaaaattag ctgggtgtgg tggcatgtgc ctgtagtctt agctacttga   2700

gaggctgagg caggagaatc gcttgaacct gggaggcaga ggttgcagtg agctgagatc   2760

atgccactgt gctccagcct ggtggcacag tgagactcca cctcaaaaaa aaaaaaaaat   2820

ccttgaacta atgactcaaa ttttcaaatg aaacaaaata agcagtggat cttgcattgg   2880

agatggagtt aaactatgtt gcccaggctg gtcttggact cctggtttca agtgatcctc   2940

tcatcttggc ctcccaaagt gctgggatta cagggacgag ccaccacacc ccacctattg   3000

tctatatttc tatctttaac agcacttcag tcctgcctta agttatagtt atgtatagat   3060

acccattata ctttaaattt ttcagcagaa attatgcttt tatcttctct gcagtgttat   3120

atgttggtgt gcaaaaatgt taaatttatt tttcctaagt accccatctg cttttcaact   3180

ctgtcctctg cctgaaaagc ctccctccag cccctacttc cctcccatct tagttcacaa   3240

agtcaggttg atttgccccc agctgtcaaa gcagactacc tgtttccaca tgtaactggt   3300

tatgttctgt aaagttacaa aaatagaaag gttgaatctg tggcggccgg gtacggtagc   3360

tcacgtccta tagtcgcagc actttgggag gccaaggtgg gcagttcacg tgaggtgggg   3420

agttcgagac cagcctgacc aacatggaga aaccccgtct ctactaaaaa tacaaaaata   3480

ttagccgggc gtggtggtgc atgcctgtaa tcccagctac tagggaggct gaggcaggag   3540

aattgcttga acctgggaga cggaggttgc ggtgagctgc agaggcctca cctctaattg   3600

agacacaatt atatattgtt gatatatata tatatatata tacacacaca cacacacact   3660

atgatggata aatgcatgag tttctgtgag agcattggaa aggagtttgt cactcaatag   3720

gtgaagccag gctaagattt aagctgagcc agggaggact tgaaggaatc atgatgagag   3780

agaaggtaag tggctttgcc agcaatgaaa cagctgacat aatggtaacc agtcagagga   3840

gggcataact atgaaactgg acaccttggt tgtcaggtta gaaggatggg gtgtagggtt   3900

ggtaagaaaa gaattcaggg aagagcagcg atcagattat gaagaatttg tcttgagaaa   3960

ttacagagga tttaaaccag aatgttagga atagttattc tagcaagatg aatgtggaaa   4020

gtgttagtgt gcatgtgatg agtcttgaag ctggaaacta ggtaacaggt tcttaaatag   4080

ttcatgtgaa aatcatgaca gactaaggca gtggctgtgg ggctgtccgg gagttctcta   4140

cagaaaacat ctaaaacttg aatgtgcaag tgagtagcta acttccaagc ttcccatttc   4200

tgtataattt aagcatgaaa atgagaacac tgagatttga taggcatgta gaagtcagag   4260

taagcaagag ggcttgagtt catcgatgaa cttcagtaac tatccttgac ttagtattgg   4320

tggaaaccat ttgtgaattt acagactcca aaaacaaaaa gataatttag agtctcaaag   4380

taagatttgg ggagatgtcc attggagaca gaagtggaga gagggagaag ttcatttgtt   4440

gacatattta tgtatggtgc acctactgtg tgccaagcca tgttagagat acagtgggag   4500

caaaaccaga tgtgttttct gccctctgac tccagtggtt gcagaattag cccaggaact   4560

agaattggat ggagtcacac aaaccaagga aggggattgt ttgagggggg cactcagtca   4620

catgtggctg aggccaaaga gaatgaagat atattttaaa attctggatt tggcaaaatt   4680

taggctagtc tttacttttc ataaacctct ctcatgttag agcagcaaag aaaaaccagt   4740

ttgccaagag gtcacgagat tgggcagtga ggaatgggga gtttagttta aaagacaaca   4800

ctagatactt ttggaagttt acctattctg tggttccctt ttattgacta aatggtgccc   4860

ttcattcatg aagcaagtat ctatttagtg actactatgt gtcaaaagct atctaggccc   4920

agaaactttt aagtggaaaa caaaacaaag accctgccct gacagatttc aatcatgtat   4980

atactgtatg tatgtttgtg gaaggtgaca taatagacaa ttgcagatag tgataagtgt   5040

gtaagacaag gataccacga gcgtaataga cagtggggat ggaggaacct ttagaaggtt   5100

ggttaagttg aatgataagg agccattctt ttgtctttac ctgaatgact tatcattcag   5160

ccctttttga gttttgggtt gcttgcagag tttaaccttg cctgtaattg aaacttaatt   5220

ttgtaatagc ataacttcat gtaagaaaag caaagcaata cattacagaa ttattttact   5280

gaagaacttg tttcagagaa agaggctgtt tcacatttat tagcacattt ggattatatt   5340

taggtgtttt attttttttt aaacaaagga gtttggatca taatacaaga gaagcacagg   5400

gcaaagacac tgcataacct caagaactaa gaatggaagg actggccagg cctggtggtg   5460

cacacctgta atcccagcta ctcaggaggc tgaggcgaga gaatcgcttg agcctggggg   5520

gcagaggttg cagtgagctg agagaacggc gggcggcaga gcgagactcc atctcaaaaa   5580

aaaaaaagga taaaggaagg acttaagcaa aatcttcctt gtaagtagaa ggatgttttg   5640

acaagaaaag ttgcaatgga aaaatggttc tcatgtacac gagtatgtag aataagcatc   5700

gtgtgtggat tggattcaga tcaaaacatt gcttttatgt ttgtgtcttt atacggtggg   5760

agtataccct ggtgccccag gatgaagact tgacctgacc catgtatttt tagattactc   5820

acagataaca aaaagtattt tcatcatgat tagttgcgaa aacagtttta tttcaatagg   5880

taaaacgtgc agtcctatgt aatcgtcaga aggtaatctt aattatagct tgggtgtgct   5940

ttaaactgca agctggcagt ggagggcacg attcctctga tttcagcttt ctccttatac   6000

ttttctggag ctgtgagctg caagttaact cagtgggatt aaagtgtaga ctggaggtac   6060

aaaaggtgag gagtgaggag atagggtagt tcttccttgg ctggctggct tcataatccc   6120

tgggccccgc agataattaa atcgactttt tctgtctcag gcatttgtat gacctctttg   6180

gaggttccct gctgggtagt tatccttgta tctgatggac ccatctcaat ttaaaatact   6240

ctgccaggtt cggaggttca tgcttgtcat cccagcactt tgggaggctc agaggtgcca   6300

ttggcttgag cccaagagtt tgagaccagc ctgggcaacc tggtgaaacc tcttctccat   6360

taaaaataca aaaaattagc caggcatggt ggtatgtgcc tgtagtccca gctactcagg   6420

gagctgaggt ggaaggattg cttgagcctg ggaggtcaag gctgcagtga accttgattg   6480

tgccactgca ctccagcctg gatgacaaag accctgtctc aagaaaagtc tgtaattctt   6540

tcctaaccct tagtatccag cctcagtcct gaggttttct ttacctctgg gggctatttt   6600

atgccggctc tctcctgagt gtcacacatc tggtcctcag gaaacattct cacatccctg   6660

gcctgaaaaa aacaatttca gggagatcgc atggcagcag ccctctctgg gctccccagc   6720

taaatggttg tacgaaacac atttcaaagc tctctgaagg gcttccttga agttcctttc   6780

actgggtttc aaagtagaag gtagtaactc ctttgtccaa gaaggctgaa ttgagcactt   6840

aacaattctc caaagaaatt tcttcattgg tctctatcct agaccccttc tgtatccttg   6900

atatggctga ggattctaaa aaatgaccag tcttacatgg gagggctggg atataaaaaa   6960

taaaataata aataatgata aaaactgaaa actg                               6994


<210>  2101
<211>  64
<212>  PRT
<213>  Homo sapiens

<400>  2101


Met Cys Arg Arg Arg Glu Arg His Arg Leu Glu Ser Val Ala Ile Arg 
1               5                   10                  15      


Arg Thr Arg Cys Ala Ala Ala Val Ala Leu Arg Pro Thr Thr Phe Arg 
            20                  25                  30          


Ser Arg Pro Val Ala Asn Val Ala Thr Leu Pro Ser Ala Arg Glu Ser 
        35                  40                  45              


Ile Thr Gly Val Pro Arg Leu Lys Asp Glu Ile Pro Pro Glu Asn Thr 
    50                  55                  60                  

<210>  2102
<211>  5065
<212>  DNA
<213>  Homo sapiens

<400>  2102
cagaagcgag atggtgagtt gtgactgtgg tgtttgtgaa tcgcgttcca tcctcgtcct     60

ttgtgcctct ctgtttgctg tgcttggggg gctggcaaga ttccggataa ggggaactgg    120

tgggctggaa agaggcatgc ggtggccctc aagagccaga agaatgactg ctaactggtg    180

cctgggggac ctatcccgcc gtaattgtgg tgctagagcc gcattgtgtc ctttgcctcg    240

gtccaacctt tggagacctt tcacggctct agccttggtt gggagccgag ggaaggagtt    300

tgggaatgtt tggctctgtg taacaatgaa ataattcatt ggtgatgctc tctggccgga    360

gtctgtaaag ataaggtgca tttcagaaca ttgcaactct tgcggagggt tttaggtaac    420

gtgaaatgcg ggtagtggtc tctgacttgg cattcgtgga aagaggcttc tcccgcagtt    480

tcgatcttta cgattgcctt taaattttat cagtaattgg tttcccggag aactcgagta    540

aatctagaag ttgccaggtt tcagaactat ttattccttt aatgtgcaga cgaagggaac    600

gtcatcgttt ggaaagcgtc gcaataagac gcacacgttg tgccgccgct gtggctctaa    660

ggcctaccac cttcagaagt cgacctgtgg caaatgtggc taccctgcca agcgcaagag    720

aaagtataac tggagtgcca aggctaaaag acgaaatacc accggaactg gtcgaatgag    780

gcaggagaat cgcttgaacc tgggaggcag aggttgcagt gagctgagat catgccactg    840

tgctccagcc tggtggcaca gtgagactcc acctcaaaaa aaaaaaaaaa tccttgaact    900

aatgactcaa attttcaaat gaaacaaaat aagcagtgga tcttgcattg gagatggagt    960

taaactatgt tgcccaggct ggtcttggac tcctggtttc aagtgatcct ctcatcttgg   1020

cctcccaaag tgctgggatt acagggacga gccaccacac cccacctatt gtctatattt   1080

ctatctttaa cagcacttca gtcctgcctt aagttatagt tatgtataga tacccattat   1140

actttaaatt tttcagcaga aattatgctt ttatcttctc tgcagtgtta tatgttggtg   1200

tgcaaaaatg ttaaatttat ttttcctaag taccccatct gcttttcaac tctgtcctct   1260

gcctgaaaag cctccctcca gcccctactt ccctcccatc ttagttcaca aagtcaggtt   1320

gatttgcccc cagctgtcaa agcagactac ctgtttccac atgtaactgg ttatgttctg   1380

taaagttaca aaaatagaaa ggttgaatct gtggcggccg ggtacggtag ctcacgtcct   1440

atagtcgcag cactttggga ggccaaggtg ggcagttcac gtgaggtggg gagttcgaga   1500

ccagcctgac caacatggag aaaccccgtc tctactaaaa atacaaaaat attagccggg   1560

cgtggtggtg catgcctgta atcccagcta ctagggaggc tgaggcagga gaattgcttg   1620

aacctgggag acggaggttg cggtgagctg cagaggcctc acctctaatt gagacacaat   1680

tatatattgt tgatatatat atatatatat atacacacac acacacacac tatgatggat   1740

aaatgcatga gtttctgtga gagcattgga aaggagtttg tcactcaata ggtgaagcca   1800

ggctaagatt taagctgagc cagggaggac ttgaaggaat catgatgaga gagaaggtaa   1860

gtggctttgc cagcaatgaa acagctgaca taatggtaac cagtcagagg agggcataac   1920

tatgaaactg gacaccttgg ttgtcaggtt agaaggatgg ggtgtagggt tggtaagaaa   1980

agaattcagg gaagagcagc gatcagatta tgaagaattt gtcttgagaa attacagagg   2040

atttaaacca gaatgttagg aatagttatt ctagcaagat gaatgtggaa agtgttagtg   2100

tgcatgtgat gagtcttgaa gctggaaact aggtaacagg ttcttaaata gttcatgtga   2160

aaatcatgac agactaaggc agtggctgtg gggctgtccg ggagttctct acagaaaaca   2220

tctaaaactt gaatgtgcaa gtgagtagct aacttccaag cttcccattt ctgtataatt   2280

taagcatgaa aatgagaaca ctgagatttg ataggcatgt agaagtcaga gtaagcaaga   2340

gggcttgagt tcatcgatga acttcagtaa ctatccttga cttagtattg gtggaaacca   2400

tttgtgaatt tacagactcc aaaaacaaaa agataattta gagtctcaaa gtaagatttg   2460

gggagatgtc cattggagac agaagtggag agagggagaa gttcatttgt tgacatattt   2520

atgtatggtg cacctactgt gtgccaagcc atgttagaga tacagtggga gcaaaaccag   2580

atgtgttttc tgccctctga ctccagtggt tgcagaatta gcccaggaac tagaattgga   2640

tggagtcaca caaaccaagg aaggggattg tttgaggggg gcactcagtc acatgtggct   2700

gaggccaaag agaatgaaga tatattttaa aattctggat ttggcaaaat ttaggctagt   2760

ctttactttt cataaacctc tctcatgtta gagcagcaaa gaaaaaccag tttgccaaga   2820

ggtcacgaga ttgggcagtg aggaatgggg agtttagttt aaaagacaac actagatact   2880

tttggaagtt tacctattct gtggttccct tttattgact aaatggtgcc cttcattcat   2940

gaagcaagta tctatttagt gactactatg tgtcaaaagc tatctaggcc cagaaacttt   3000

taagtggaaa acaaaacaaa gaccctgccc tgacagattt caatcatgta tatactgtat   3060

gtatgtttgt ggaaggtgac ataatagaca attgcagata gtgataagtg tgtaagacaa   3120

ggataccacg agcgtaatag acagtgggga tggaggaacc tttagaaggt tggttaagtt   3180

gaatgataag gagccattct tttgtcttta cctgaatgac ttatcattca gccctttttg   3240

agttttgggt tgcttgcaga gtttaacctt gcctgtaatt gaaacttaat tttgtaatag   3300

cataacttca tgtaagaaaa gcaaagcaat acattacaga attattttac tgaagaactt   3360

gtttcagaga aagaggctgt ttcacattta ttagcacatt tggattatat ttaggtgttt   3420

tatttttttt taaacaaagg agtttggatc ataatacaag agaagcacag ggcaaagaca   3480

ctgcataacc tcaagaacta agaatggaag gactggccag gcctggtggt gcacacctgt   3540

aatcccagct actcaggagg ctgaggcgag agaatcgctt gagcctgggg ggcagaggtt   3600

gcagtgagct gagagaacgg cgggcggcag agcgagactc catctcaaaa aaaaaaaagg   3660

ataaaggaag gacttaagca aaatcttcct tgtaagtaga aggatgtttt gacaagaaaa   3720

gttgcaatgg aaaaatggtt ctcatgtaca cgagtatgta gaataagcat cgtgtgtgga   3780

ttggattcag atcaaaacat tgcttttatg tttgtgtctt tatacggtgg gagtataccc   3840

tggtgcccca ggatgaagac ttgacctgac ccatgtattt ttagattact cacagataac   3900

aaaaagtatt ttcatcatga ttagttgcga aaacagtttt atttcaatag gtaaaacgtg   3960

cagtcctatg taatcgtcag aaggtaatct taattatagc ttgggtgtgc tttaaactgc   4020

aagctggcag tggagggcac gattcctctg atttcagctt tctccttata cttttctgga   4080

gctgtgagct gcaagttaac tcagtgggat taaagtgtag actggaggta caaaaggtga   4140

ggagtgagga gatagggtag ttcttccttg gctggctggc ttcataatcc ctgggccccg   4200

cagataatta aatcgacttt ttctgtctca ggcatttgta tgacctcttt ggaggttccc   4260

tgctgggtag ttatccttgt atctgatgga cccatctcaa tttaaaatac tctgccaggt   4320

tcggaggttc atgcttgtca tcccagcact ttgggaggct cagaggtgcc attggcttga   4380

gcccaagagt ttgagaccag cctgggcaac ctggtgaaac ctcttctcca ttaaaaatac   4440

aaaaaattag ccaggcatgg tggtatgtgc ctgtagtccc agctactcag ggagctgagg   4500

tggaaggatt gcttgagcct gggaggtcaa ggctgcagtg aaccttgatt gtgccactgc   4560

actccagcct ggatgacaaa gaccctgtct caagaaaagt ctgtaattct ttcctaaccc   4620

ttagtatcca gcctcagtcc tgaggttttc tttacctctg ggggctattt tatgccggct   4680

ctctcctgag tgtcacacat ctggtcctca ggaaacattc tcacatccct ggcctgaaaa   4740

aaacaatttc agggagatcg catggcagca gccctctctg ggctccccag ctaaatggtt   4800

gtacgaaaca catttcaaag ctctctgaag ggcttccttg aagttccttt cactgggttt   4860

caaagtagaa ggtagtaact cctttgtcca agaaggctga attgagcact taacaattct   4920

ccaaagaaat ttcttcattg gtctctatcc tagacccctt ctgtatcctt gatatggctg   4980

aggattctaa aaaatgacca gtcttacatg ggagggctgg gatataaaaa ataaaataat   5040

aaataatgat aaaaactgaa aactg                                         5065


<210>  2103
<211>  65
<212>  PRT
<213>  Homo sapiens

<400>  2103


Met Cys Arg Arg Arg Glu Arg His Arg Leu Glu Ser Val Ala Ile Arg 
1               5                   10                  15      


Arg Thr Arg Cys Ala Ala Ala Val Ala Leu Arg Pro Thr Thr Phe Arg 
            20                  25                  30          


Ser Arg Pro Val Ala Asn Val Ala Thr Leu Pro Ser Ala Arg Glu Ser 
        35                  40                  45              


Ile Thr Gly Val Pro Arg Leu Lys Asp Glu Ile Pro Pro Glu Leu Val 
    50                  55                  60                  


Glu 
65  

<210>  2104
<211>  6550
<212>  DNA
<213>  Homo sapiens

<400>  2104
ctgggcggaa gcttctgagc gtgatatagc ggaagtgcct tctcttccgg tctttctggt     60

ctcggccgca gaagcgagat gacgaaggga acgtcatcgt ttggaaagcg tcgcaataag    120

acgcacacgt tgtgccgccg ctgtggctct aaggcctacc accttcagaa gtcgacctgt    180

ggcaaatgtg gctaccctgc caagcgcaag agaaagtata actggagtgc caaggctaaa    240

agacgaaata ccaccggaac tggtcgaatg aggcacctaa aaattgtata ccgcagattc    300

aggcatggat tccgtgaagg aacaacacct aaacccaaga gggcagctgt tgcagcatcc    360

agttcatctt aagaatgtca acgattagtc atgcaataaa tgttctggtt ttaaaaaata    420

catatctggt tttggtaagg tatttttaat caattaggct tgtagtatca gtgaaatact    480

gtaggtttag ggactgggct agcttcatat cagatttact tgttaagtga ctgttttgga    540

atgtttactt ttggactggg tttgtaacac ggttaaaggc aatgagaaac aagcagaatt    600

ccaggagtcc ttgaagcaga gggcactgga agacaatata gcagattaaa atagcacagc    660

tcatgtggca taggtgggta ttttagatgt ttgagtaaat ttgaaagagt atgatgttta    720

aattaccttt agcaacatgt tcatctgcta tgctgtcatg actaggggga tgattattag    780

tcacatagag cttgggagta ccactggaaa cgtatgggta ggagtttagg tggcttctgt    840

ttttcaaaag atgatcttat cctagtatct gtaatgctca cttggcacac ctgacttgtg    900

ggctgtgtgt aaggtggcta gctaagtgaa aaaagcctgc taggtgtgag tcaacttaag    960

aatatgtaaa taggtttgag aaaaagtagg gcttgggtgc aagtaaagat tgagcaggaa   1020

ataaaggaaa atcaagtata atccctgaga tttgtagact aaaggcaatg atgtgggact   1080

acttggtcga atttttttag ccctcaactt ggtaattggg tgtttctgtg ttaaagcact   1140

gaaacttgct gtcgtgcctt cctagttttc gtggtttatt gacagggttg ggggtttttt   1200

ttgttttttt aaaatgaagg gacaaagtca actggactgc tgagtgagag ggcaggggca   1260

gttgaaggga acatgaattg ctggaacagc tacataaaat agtgatgtag ccaagtcatg   1320

ctatttaaat tataattctc cactgtgttt agaataacat ctgaggttct taacctggcc   1380

ttggaagggt atcactttta cttgtaacct ggaatggctt tataatgtgc tagctaattg   1440

ctactctcat cttgtatttt aactcctaat ttacccttca ggtctcagct tcagaacatt   1500

cacttataaa gaaaccctgc tgattaaatc tctcttgggc ttcctcccga aatgtgagac   1560

tatactttaa agatgtatgg ttagagtcca attgccattg cctttcttgt ttacagatag   1620

tgcaatggcg caatcctggc tcactgcagc ctctaattcc tgggctcaag tcaagtggtt   1680

ctcctgcctc agccttctga gtagctggga ctacagatgc acaccaccac acctggctaa   1740

tttttgtgtt ttttgtagag atggagattc actcgactaa ttctttttgt attcttagta   1800

gagactgggt ttcaacatgt tgaccaggct ggtctcgaac tcgacctcgt gatccgccgc   1860

ctcggcctcc caaagtgcta ggattacagg cgtgagccac cactcccggc tgtcatcatc   1920

aaattttcaa gtgaagatag tctgttgaag attgaacaat gaccttgaaa gacagctgag   1980

ttgctgtggg tataatgtaa agctggtgaa gtttggccag tttgggcttc agaagtctaa   2040

gtctagtgaa ggtaccctga cccccatata aacaaccctt gaggccggtg tggtggctca   2100

cggctgtaat cctggcactt tgggaggccg aggtgggcgg atcacaaggt caagagatcg   2160

agatcaccct ggcccacatg gtgagacccc aactctacta aaaatacaaa aattagctgg   2220

gtgtggtggc atgtgcctgt agtcttagct acttgagagg ctgaggcagg agaatcgctt   2280

gaacctggga ggcagaggtt gcagtgagct gagatcatgc cactgtgctc cagcctggtg   2340

gcacagtgag actccacctc aaaaaaaaaa aaaaatcctt gaactaatga ctcaaatttt   2400

caaatgaaac aaaataagca gtggatcttg cattggagat ggagttaaac tatgttgccc   2460

aggctggtct tggactcctg gtttcaagtg atcctctcat cttggcctcc caaagtgctg   2520

ggattacagg gacgagccac cacaccccac ctattgtcta tatttctatc tttaacagca   2580

cttcagtcct gccttaagtt atagttatgt atagataccc attatacttt aaatttttca   2640

gcagaaatta tgcttttatc ttctctgcag tgttatatgt tggtgtgcaa aaatgttaaa   2700

tttatttttc ctaagtaccc catctgcttt tcaactctgt cctctgcctg aaaagcctcc   2760

ctccagcccc tacttccctc ccatcttagt tcacaaagtc aggttgattt gcccccagct   2820

gtcaaagcag actacctgtt tccacatgta actggttatg ttctgtaaag ttacaaaaat   2880

agaaaggttg aatctgtggc ggccgggtac ggtagctcac gtcctatagt cgcagcactt   2940

tgggaggcca aggtgggcag ttcacgtgag gtggggagtt cgagaccagc ctgaccaaca   3000

tggagaaacc ccgtctctac taaaaataca aaaatattag ccgggcgtgg tggtgcatgc   3060

ctgtaatccc agctactagg gaggctgagg caggagaatt gcttgaacct gggagacgga   3120

ggttgcggtg agctgcagag gcctcacctc taattgagac acaattatat attgttgata   3180

tatatatata tatatataca cacacacaca cacactatga tggataaatg catgagtttc   3240

tgtgagagca ttggaaagga gtttgtcact caataggtga agccaggcta agatttaagc   3300

tgagccaggg aggacttgaa ggaatcatga tgagagagaa ggtaagtggc tttgccagca   3360

atgaaacagc tgacataatg gtaaccagtc agaggagggc ataactatga aactggacac   3420

cttggttgtc aggttagaag gatggggtgt agggttggta agaaaagaat tcagggaaga   3480

gcagcgatca gattatgaag aatttgtctt gagaaattac agaggattta aaccagaatg   3540

ttaggaatag ttattctagc aagatgaatg tggaaagtgt tagtgtgcat gtgatgagtc   3600

ttgaagctgg aaactaggta acaggttctt aaatagttca tgtgaaaatc atgacagact   3660

aaggcagtgg ctgtggggct gtccgggagt tctctacaga aaacatctaa aacttgaatg   3720

tgcaagtgag tagctaactt ccaagcttcc catttctgta taatttaagc atgaaaatga   3780

gaacactgag atttgatagg catgtagaag tcagagtaag caagagggct tgagttcatc   3840

gatgaacttc agtaactatc cttgacttag tattggtgga aaccatttgt gaatttacag   3900

actccaaaaa caaaaagata atttagagtc tcaaagtaag atttggggag atgtccattg   3960

gagacagaag tggagagagg gagaagttca tttgttgaca tatttatgta tggtgcacct   4020

actgtgtgcc aagccatgtt agagatacag tgggagcaaa accagatgtg ttttctgccc   4080

tctgactcca gtggttgcag aattagccca ggaactagaa ttggatggag tcacacaaac   4140

caaggaaggg gattgtttga ggggggcact cagtcacatg tggctgaggc caaagagaat   4200

gaagatatat tttaaaattc tggatttggc aaaatttagg ctagtcttta cttttcataa   4260

acctctctca tgttagagca gcaaagaaaa accagtttgc caagaggtca cgagattggg   4320

cagtgaggaa tggggagttt agtttaaaag acaacactag atacttttgg aagtttacct   4380

attctgtggt tcccttttat tgactaaatg gtgcccttca ttcatgaagc aagtatctat   4440

ttagtgacta ctatgtgtca aaagctatct aggcccagaa acttttaagt ggaaaacaaa   4500

acaaagaccc tgccctgaca gatttcaatc atgtatatac tgtatgtatg tttgtggaag   4560

gtgacataat agacaattgc agatagtgat aagtgtgtaa gacaaggata ccacgagcgt   4620

aatagacagt ggggatggag gaacctttag aaggttggtt aagttgaatg ataaggagcc   4680

attcttttgt ctttacctga atgacttatc attcagccct ttttgagttt tgggttgctt   4740

gcagagttta accttgcctg taattgaaac ttaattttgt aatagcataa cttcatgtaa   4800

gaaaagcaaa gcaatacatt acagaattat tttactgaag aacttgtttc agagaaagag   4860

gctgtttcac atttattagc acatttggat tatatttagg tgttttattt ttttttaaac   4920

aaaggagttt ggatcataat acaagagaag cacagggcaa agacactgca taacctcaag   4980

aactaagaat ggaaggactg gccaggcctg gtggtgcaca cctgtaatcc cagctactca   5040

ggaggctgag gcgagagaat cgcttgagcc tggggggcag aggttgcagt gagctgagag   5100

aacggcgggc ggcagagcga gactccatct caaaaaaaaa aaaggataaa ggaaggactt   5160

aagcaaaatc ttccttgtaa gtagaaggat gttttgacaa gaaaagttgc aatggaaaaa   5220

tggttctcat gtacacgagt atgtagaata agcatcgtgt gtggattgga ttcagatcaa   5280

aacattgctt ttatgtttgt gtctttatac ggtgggagta taccctggtg ccccaggatg   5340

aagacttgac ctgacccatg tatttttaga ttactcacag ataacaaaaa gtattttcat   5400

catgattagt tgcgaaaaca gttttatttc aataggtaaa acgtgcagtc ctatgtaatc   5460

gtcagaaggt aatcttaatt atagcttggg tgtgctttaa actgcaagct ggcagtggag   5520

ggcacgattc ctctgatttc agctttctcc ttatactttt ctggagctgt gagctgcaag   5580

ttaactcagt gggattaaag tgtagactgg aggtacaaaa ggtgaggagt gaggagatag   5640

ggtagttctt ccttggctgg ctggcttcat aatccctggg ccccgcagat aattaaatcg   5700

actttttctg tctcaggcat ttgtatgacc tctttggagg ttccctgctg ggtagttatc   5760

cttgtatctg atggacccat ctcaatttaa aatactctgc caggttcgga ggttcatgct   5820

tgtcatccca gcactttggg aggctcagag gtgccattgg cttgagccca agagtttgag   5880

accagcctgg gcaacctggt gaaacctctt ctccattaaa aatacaaaaa attagccagg   5940

catggtggta tgtgcctgta gtcccagcta ctcagggagc tgaggtggaa ggattgcttg   6000

agcctgggag gtcaaggctg cagtgaacct tgattgtgcc actgcactcc agcctggatg   6060

acaaagaccc tgtctcaaga aaagtctgta attctttcct aacccttagt atccagcctc   6120

agtcctgagg ttttctttac ctctgggggc tattttatgc cggctctctc ctgagtgtca   6180

cacatctggt cctcaggaaa cattctcaca tccctggcct gaaaaaaaca atttcaggga   6240

gatcgcatgg cagcagccct ctctgggctc cccagctaaa tggttgtacg aaacacattt   6300

caaagctctc tgaagggctt ccttgaagtt cctttcactg ggtttcaaag tagaaggtag   6360

taactccttt gtccaagaag gctgaattga gcacttaaca attctccaaa gaaatttctt   6420

cattggtctc tatcctagac cccttctgta tccttgatat ggctgaggat tctaaaaaat   6480

gaccagtctt acatgggagg gctgggatat aaaaaataaa ataataaata atgataaaaa   6540

ctgaaaactg                                                          6550


<210>  2105
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  2105


Met Thr Lys Gly Thr Ser Ser Phe Gly Lys Arg Arg Asn Lys Thr His 
1               5                   10                  15      


Thr Leu Cys Arg Arg Cys Gly Ser Lys Ala Tyr His Leu Gln Lys Ser 
            20                  25                  30          


Thr Cys Gly Lys Cys Gly Tyr Pro Ala Lys Arg Lys Arg Lys Tyr Asn 
        35                  40                  45              


Trp Ser Ala Lys Ala Lys Arg Arg Asn Thr Thr Gly Thr Gly Arg Met 
    50                  55                  60                  


Arg His Leu Lys Ile Val Tyr Arg Arg Phe Arg His Gly Phe Arg Glu 
65                  70                  75                  80  


Gly Thr Thr Pro Lys Pro Lys Arg Ala Ala Val Ala Ala Ser Ser Ser 
                85                  90                  95      


Ser 
    

<210>  2106
<211>  2132
<212>  DNA
<213>  Homo sapiens

<400>  2106
ctcttgaccc cacctacact acgacgacgg acgctcgaga acgctgcacc gcgccccgca     60

ggaagtgctt ccctgggcgg aagcttctga gcgtgatata gcggaagtgc cttctcttcc    120

ggtctttctg gtctcggccg cagaagcgag atgacgaagg gaacgtcatc gtttggaaag    180

cgtcgcaata agacgcacac gttgtgccgc cgctgtggct ctaaggccta ccaccttcag    240

aagtcgacct gtggcaaatg tggctaccct gccaagcgca agagaaagta taactggagt    300

gccaaggcta aaagacgaaa taccaccgga actggtcgaa tgaggcacct aaaaattgta    360

taccgcagat tcaggcatgg attccgtgaa ggaacaacac ctaaacccaa gagggcagct    420

gttgcagcat ccagttcatc ttaagaatgt caacgattag tcatgcaata aatgttctgg    480

ttttaaaaaa tacatatctg gttttggagt ttggatcata atacaagaga agcacagggc    540

aaagacactg cataacctca agaactaaga atggaaggac tggccaggcc tggtggtgca    600

cacctgtaat cccagctact caggaggctg aggcgagaga atcgcttgag cctggggggc    660

agaggttgca gtgagctgag agaacggcgg gcggcagagc gagactccat ctcaaaaaaa    720

aaaaaggata aaggaaggac ttaagcaaaa tcttccttgt aagtagaagg atgttttgac    780

aagaaaagtt gcaatggaaa aatggttctc atgtacacga gtatgtagaa taagcatcgt    840

gtgtggattg gattcagatc aaaacattgc ttttatgttt gtgtctttat acggtgggag    900

tataccctgg tgccccagga tgaagacttg acctgaccca tgtattttta gattactcac    960

agataacaaa aagtattttc atcatgatta gttgcgaaaa cagttttatt tcaataggta   1020

aaacgtgcag tcctatgtaa tcgtcagaag gtaatcttaa ttatagcttg ggtgtgcttt   1080

aaactgcaag ctggcagtgg agggcacgat tcctctgatt tcagctttct ccttatactt   1140

ttctggagct gtgagctgca agttaactca gtgggattaa agtgtagact ggaggtacaa   1200

aaggtgagga gtgaggagat agggtagttc ttccttggct ggctggcttc ataatccctg   1260

ggccccgcag ataattaaat cgactttttc tgtctcaggc atttgtatga cctctttgga   1320

ggttccctgc tgggtagtta tccttgtatc tgatggaccc atctcaattt aaaatactct   1380

gccaggttcg gaggttcatg cttgtcatcc cagcactttg ggaggctcag aggtgccatt   1440

ggcttgagcc caagagtttg agaccagcct gggcaacctg gtgaaacctc ttctccatta   1500

aaaatacaaa aaattagcca ggcatggtgg tatgtgcctg tagtcccagc tactcaggga   1560

gctgaggtgg aaggattgct tgagcctggg aggtcaaggc tgcagtgaac cttgattgtg   1620

ccactgcact ccagcctgga tgacaaagac cctgtctcaa gaaaagtctg taattctttc   1680

ctaaccctta gtatccagcc tcagtcctga ggttttcttt acctctgggg gctattttat   1740

gccggctctc tcctgagtgt cacacatctg gtcctcagga aacattctca catccctggc   1800

ctgaaaaaaa caatttcagg gagatcgcat ggcagcagcc ctctctgggc tccccagcta   1860

aatggttgta cgaaacacat ttcaaagctc tctgaagggc ttccttgaag ttcctttcac   1920

tgggtttcaa agtagaaggt agtaactcct ttgtccaaga aggctgaatt gagcacttaa   1980

caattctcca aagaaatttc ttcattggtc tctatcctag accccttctg tatccttgat   2040

atggctgagg attctaaaaa atgaccagtc ttacatggga gggctgggat ataaaaaata   2100

aaataataaa taatgataaa aactgaaaac tg                                 2132


<210>  2107
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  2107


Met Thr Lys Gly Thr Ser Ser Phe Gly Lys Arg Arg Asn Lys Thr His 
1               5                   10                  15      


Thr Leu Cys Arg Arg Cys Gly Ser Lys Ala Tyr His Leu Gln Lys Ser 
            20                  25                  30          


Thr Cys Gly Lys Cys Gly Tyr Pro Ala Lys Arg Lys Arg Lys Tyr Asn 
        35                  40                  45              


Trp Ser Ala Lys Ala Lys Arg Arg Asn Thr Thr Gly Thr Gly Arg Met 
    50                  55                  60                  


Arg His Leu Lys Ile Val Tyr Arg Arg Phe Arg His Gly Phe Arg Glu 
65                  70                  75                  80  


Gly Thr Thr Pro Lys Pro Lys Arg Ala Ala Val Ala Ala Ser Ser Ser 
                85                  90                  95      


Ser 
    

<210>  2108
<211>  860
<212>  DNA
<213>  Homo sapiens

<400>  2108
ctcttgaccc cacctacact acgacgacgg acgctcgaga acgctgcacc gcgccccgca     60

ggaagtgctt ccctgggcgg aagcttctga gcgtgatata gcggaagtgc cttctcttcc    120

ggtctttctg gtctcggccg cagaagcgag atgacgaagg gaacgtcatc gtttggaaag    180

cgtcgcaata agacgcacac gttgtgccgc cgctgtggct ctaaggccta ccaccttcag    240

aagtcgacct gtggcaaatg tggctaccct gccaagcgca agagaaagta taactggagt    300

gccaaggcta aaagacgaaa taccaccgga actggtcgaa tgaggcacct aaaaattgta    360

taccgcagat tcaggcatgg attccgtgaa ggaacaacac ctaaacccaa gagggcagct    420

gttgcagcat ccagttcatc ttaagaatgt caacgattag tcatgcaata aatgttctgg    480

ttttaaaaaa tacatatctg gttttggagt ttggatcata atacaagaga agcacagggc    540

aaagacactg cataacctca agaactaaga atggaaggac tggccaggcc tggtggtgca    600

cacctgtaat cccagctact caggaggctg aggcgagaga atcgcttgag cctggggggc    660

agaggttgca gtgagctgag agaacggcgg gcggcagagc gagactccat ctcaaaaaaa    720

aaaaaggata aaggaaggac ttaagcaaaa tcttccttgt aagtagaagg atgttttgac    780

aagaaaagtt gcaatggaaa aatggttctc atgtacacga gtatgtagaa taagcatcgt    840

gtgtggattg gattcagatc                                                860


<210>  2109
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  2109


Met Thr Lys Gly Thr Ser Ser Phe Gly Lys Arg Arg Asn Lys Thr His 
1               5                   10                  15      


Thr Leu Cys Arg Arg Cys Gly Ser Lys Ala Tyr His Leu Gln Lys Ser 
            20                  25                  30          


Thr Cys Gly Lys Cys Gly Tyr Pro Ala Lys Arg Lys Arg Lys Tyr Asn 
        35                  40                  45              


Trp Ser Ala Lys Ala Lys Arg Arg Asn Thr Thr Gly Thr Gly Arg Met 
    50                  55                  60                  


Arg His Leu Lys Ile Val Tyr Arg Arg Phe Arg His Gly Phe Arg Glu 
65                  70                  75                  80  


Gly Thr Thr Pro Lys Pro Lys Arg Ala Ala Val Ala Ala Ser Ser Ser 
                85                  90                  95      


Ser 
    

<210>  2110
<211>  1993
<212>  DNA
<213>  Homo sapiens

<400>  2110
cagaagcgag atggtgagtt gtgactgtgg tgtttgtgaa tcgcgttcca tcctcgtcct     60

ttgtgcctct ctgtttgctg tgcttggggg gctggcaaga ttccggataa ggggaactgg    120

tgggctggaa agaggcatgc ggtggccctc aagagccaga agaatgactg ctaactggtg    180

cctgggggac ctatcccgcc gtaattgtgg tgctagagcc gcattgtgtc ctttgcctcg    240

gtccaacctt tggagacctt tcacggctct agccttggtt gggagccgag ggaaggagtt    300

tgggaatgtt tggctctgtg taacaatgaa ataattcatt ggtgatgctc tctggccgga    360

gtctgtaaag ataaggtgca tttcagaaca ttgcaactct tgcggagggt tttaggtaac    420

gtgaaatgcg ggtagtggtc tctgacttgg cattcgtgga aagaggcttc tcccgcagtt    480

tcgatcttta cgattgcctt taaattttat cagtaattgg tttcccggag aactcgagta    540

aatctagaag ttgccaggtt tcagaactat ttattccttt aatgtgcaga cgaagggaac    600

gtcatcgttt ggaaagcgtc gcaataagac gcacacgttg tgccgccgct gtggctctaa    660

ggcctaccac cttcagaagt cgacctgtgg caaatgtggc taccctgcca agcgcaagag    720

aaagtataac tggagtgcca aggctaaaag acgaaatacc accggaaaac acctaaaccc    780

aagagggcag ctgttgcagc atccagttca tcttaagaat gtcaacgatt agtcatgcaa    840

taaatgttct ggttttaaaa aatacatatc tggttttggt aaggtatttt taatcaatta    900

ggcttgtagt atcagtgaaa tactgtaggt ttagggactg ggctagcttc atatcagatt    960

tacttgttaa gtgactgttt tggaatgttt acttttggac tgggtttgta acacggttaa   1020

aggcaatgag aaacaagcag aattccagga gtccttgaag cagagggcac tggaagacaa   1080

tatagcagat taaaatagca cagctcatgt ggcataggtg ggtattttag atgtttgagt   1140

aaatttgaaa gagtatgatg tttaaattac ctttagcaac atgttcatct gctatgctgt   1200

catgactagg gggatgatta ttagtcacat agagcttggg agtaccactg gaaacgtatg   1260

ggtaggagtt taggtggctt ctgtttttca aaagatgatc ttatcctagt atctgtaatg   1320

ctcacttggc acacctgact tgtgggctgt gtgtaaggtg gctagctaag tgaaaaaagc   1380

ctgctaggtg tgagtcaact taagaatatg taaataggtt tgagaaaaag tagggcttgg   1440

gtgcaagtaa agattgagca ggaaataaag gaaaatcaag tataatccct gagatttgta   1500

gactaaaggc aatgatgtgg gactacttgg tcgaattttt ttagccctca acttggtaat   1560

tgggtgtttc tgtgttaaag cactgaaact tgctgtcgtg ccttcctagt tttcgtggtt   1620

tattgacagg gttgggggtt ttttttgttt ttttaaaatg aagggacaaa gtcaactgga   1680

ctgctgagtg agagggcagg ggcagttgaa gggaacatga attgctggaa cagctacata   1740

aaatagtgat gtagccaagt catgctattt aaattataat tctccactgt gtttagaata   1800

acatctgagg ttcttaacct ggccttggaa gggtatcact tttacttgta acctggaatg   1860

gctttataat gtgctagcta attgctactc tcatcttgta ttttaactcc taatttaccc   1920

ttcaggtctc agcttcagaa cattcactta taaagaaacc ctgctgatta aatctctctt   1980

gggcttcctc ccg                                                      1993


<210>  2111
<211>  64
<212>  PRT
<213>  Homo sapiens

<400>  2111


Met Cys Arg Arg Arg Glu Arg His Arg Leu Glu Ser Val Ala Ile Arg 
1               5                   10                  15      


Arg Thr Arg Cys Ala Ala Ala Val Ala Leu Arg Pro Thr Thr Phe Arg 
            20                  25                  30          


Ser Arg Pro Val Ala Asn Val Ala Thr Leu Pro Ser Ala Arg Glu Ser 
        35                  40                  45              


Ile Thr Gly Val Pro Arg Leu Lys Asp Glu Ile Pro Pro Glu Asn Thr 
    50                  55                  60                  

<210>  2112
<211>  1972
<212>  DNA
<213>  Homo sapiens

<400>  2112
cagaagcgag atggtgagtt gtgactgtgg tgtttgtgaa tcgcgttcca tcctcgtcct     60

ttgtgcctct ctgtttgctg tgcttggggg gctggcaaga ttccggataa ggggaactgg    120

tgggctggaa agaggcatgc ggtggccctc aagagccaga agaatgactg ctaactggtg    180

cctgggggac ctatcccgcc gtaattgtgg tgctagagcc gcattgtgtc ctttgcctcg    240

gtccaacctt tggagacctt tcacggctct agccttggtt gggagccgag ggaaggagtt    300

tgggaatgtt tggctctgtg taacaatgaa ataattcatt ggtgatgctc tctggccgga    360

gtctgtaaag ataaggtgca tttcagaaca ttgcaactct tgcggagggt tttaggtaac    420

gtgaaatgcg ggtagtggtc tctgacttgg cattcgtgga aagaggcttc tcccgcagtt    480

tcgatcttta cgattgcctt taaattttat cagtaattgg tttcccggag aactcgagta    540

aatctagaag ttgccaggtt tcagaactat ttattccttt aatgtgcaga cgaagggaac    600

gtcatcgttt ggaaagcgtc gcaataagac gcacacgttg tgccgccgct gtggctctaa    660

ggcctaccac cttcagaagt cgacctgtgg caaatgtggc taccctgcca agcgcaagag    720

aaagtgcatg gattccgtga aggaacaaca cctaaaccca agagggcagc tgttgcagca    780

tccagttcat cttaagaatg tcaacgatta gtcatgcaat aaatgttctg gttttaaaaa    840

atacatatct ggttttggta aggtattttt aatcaattag gcttgtagta tcagtgaaat    900

actgtaggtt tagggactgg gctagcttca tatcagattt acttgttaag tgactgtttt    960

ggaatgttta cttttggact gggtttgtaa cacggttaaa ggcaatgaga aacaagcaga   1020

attccaggag tccttgaagc agagggcact ggaagacaat atagcagatt aaaatagcac   1080

agctcatgtg gcataggtgg gtattttaga tgtttgagta aatttgaaag agtatgatgt   1140

ttaaattacc tttagcaaca tgttcatctg ctatgctgtc atgactaggg ggatgattat   1200

tagtcacata gagcttggga gtaccactgg aaacgtatgg gtaggagttt aggtggcttc   1260

tgtttttcaa aagatgatct tatcctagta tctgtaatgc tcacttggca cacctgactt   1320

gtgggctgtg tgtaaggtgg ctagctaagt gaaaaaagcc tgctaggtgt gagtcaactt   1380

aagaatatgt aaataggttt gagaaaaagt agggcttggg tgcaagtaaa gattgagcag   1440

gaaataaagg aaaatcaagt ataatccctg agatttgtag actaaaggca atgatgtggg   1500

actacttggt cgaatttttt tagccctcaa cttggtaatt gggtgtttct gtgttaaagc   1560

actgaaactt gctgtcgtgc cttcctagtt ttcgtggttt attgacaggg ttgggggttt   1620

tttttgtttt tttaaaatga agggacaaag tcaactggac tgctgagtga gagggcaggg   1680

gcagttgaag ggaacatgaa ttgctggaac agctacataa aatagtgatg tagccaagtc   1740

atgctattta aattataatt ctccactgtg tttagaataa catctgaggt tcttaacctg   1800

gccttggaag ggtatcactt ttacttgtaa cctggaatgg ctttataatg tgctagctaa   1860

ttgctactct catcttgtat tttaactcct aatttaccct tcaggtctca gcttcagaac   1920

attcacttat aaagaaaccc tgctgattaa atctctcttg ggcttcctcc cg           1972


<210>  2113
<211>  52
<212>  PRT
<213>  Homo sapiens

<400>  2113


Met Cys Arg Arg Arg Glu Arg His Arg Leu Glu Ser Val Ala Ile Arg 
1               5                   10                  15      


Arg Thr Arg Cys Ala Ala Ala Val Ala Leu Arg Pro Thr Thr Phe Arg 
            20                  25                  30          


Ser Arg Pro Val Ala Asn Val Ala Thr Leu Pro Ser Ala Arg Glu Ser 
        35                  40                  45              


Ala Trp Ile Pro 
    50          

<210>  2114
<211>  1571
<212>  DNA
<213>  Homo sapiens

<400>  2114
gcgccccgca ggaagtgctt ccctgggcgg aagcttctga gcgtgatata gcggaagtgc     60

cttctcttcc ggtctttctg gtctcggccg cagaagcgag atgacgaagg gaacgtcatc    120

gtttggaaag cgtcgcaata agacgcacac gttgtgccgc cgctgtggct ctaaggccta    180

ccaccttcag aagtcgacct gtggcaaatg tggctaccct gccaagcgca agagaaagta    240

taactggagt gccaaggcta aaagacgaaa taccaccgga actggtcgaa tgaggcacct    300

aaaaattgta taccgcagat tcaggcatgg attccgtgaa ggaacaacac ctaaacccaa    360

gagggcagct gttgcagcat ccagttcatc ttaagaatgt caacgattag tcatgcaata    420

aatgttctgg ttttaaaaaa tacatatctg gttttggtaa ggtattttta atcaattagg    480

cttgtagtat cagtgaaata ctgtaggttt agggactggg ctagcttcat atcagattta    540

cttgttaagt gactgttttg gaatgtttac ttttggactg ggtttgtaac acggttaaag    600

gcaatgagaa acaagcagaa ttccaggagt ccttgaagca gagggcactg gaagacaata    660

tagcagatta aaatagcaca gctcatgtgg cataggtggg tattttagat gtttgagtaa    720

atttgaaaga gtatgatgtt taaattacct ttagcaacat gttcatctgc tatgctgtca    780

tgactagggg gatgattatt agtcacatag agcttgggag taccactgga aacgtatggg    840

taggagttta ggtggcttct gtttttcaaa agatgatctt atcctagtat ctgtaatgct    900

cacttggcac acctgacttg tgggctgtgt gtaaggtggc tagctaagtg aaaaaagcct    960

gctaggtgtg agtcaactta agaatatgta aataggtttg agaaaaagta gggcttgggt   1020

gcaagtaaag attgagcagg aaataaagga aaatcaagta taatccctga gatttgtaga   1080

ctaaaggcaa tgatgtggga ctacttggtc gaattttttt agccctcaac ttggtaattg   1140

ggtgtttctg tgttaaagca ctgaaacttg ctgtcgtgcc ttcctagttt tcgtggttta   1200

ttgacagggt tgggggtttt ttttgttttt ttaaaatgaa gggacaaagt caactggact   1260

gctgagtgag agggcagggg cagttgaagg gaacatgaat tgctggaaca gctacataaa   1320

atagtgatgt agccaagtca tgctatttaa attataattc tccactgtgt ttagaataac   1380

atctgaggtt cttaacctgg ccttggaagg gtatcacttt tacttgtaac ctggaatggc   1440

tttataatgt gctagctaat tgctactctc atcttgtatt ttaactccta atttaccctt   1500

caggtctcag cttcagaaca ttcacttata aagaaaccct gctgattaaa tctctcttgg   1560

gcttcctccc g                                                        1571


<210>  2115
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  2115


Met Thr Lys Gly Thr Ser Ser Phe Gly Lys Arg Arg Asn Lys Thr His 
1               5                   10                  15      


Thr Leu Cys Arg Arg Cys Gly Ser Lys Ala Tyr His Leu Gln Lys Ser 
            20                  25                  30          


Thr Cys Gly Lys Cys Gly Tyr Pro Ala Lys Arg Lys Arg Lys Tyr Asn 
        35                  40                  45              


Trp Ser Ala Lys Ala Lys Arg Arg Asn Thr Thr Gly Thr Gly Arg Met 
    50                  55                  60                  


Arg His Leu Lys Ile Val Tyr Arg Arg Phe Arg His Gly Phe Arg Glu 
65                  70                  75                  80  


Gly Thr Thr Pro Lys Pro Lys Arg Ala Ala Val Ala Ala Ser Ser Ser 
                85                  90                  95      


Ser 
    

<210>  2116
<211>  1489
<212>  DNA
<213>  Homo sapiens

<400>  2116
cagaagcgag atggtgagtt gtgactgtgg tgtttgtgaa tcgcgttcca tcctcgtcct     60

ttgtgcctct ctgtttgctg tgcttggggg gctggcaaga ttccggataa ggggaactgg    120

tgggctggaa agaggcatgc ggtggccctc aagagccaga agaatgactg ctaactggtg    180

cctgggggac ctatcccgcc gtaattgtgg tgctagagcc gcattgtgtc ctttgcctcg    240

gtccaacctt tggagacctt tcacggctct agccttggtt gggagccgag ggaaggagtt    300

tgggaatgtt tggctctgtg taacaatgaa ataattcatt ggtgatgctc tctggccgga    360

gtctgtaaag ataaggtgca tttcagaaca ttgcaactct tgcggagggt tttaggtaac    420

gtgaaatgcg ggtagtggtc tctgacttgg cattcgtgga aagaggcttc tcccgcagtt    480

tcgatcttta cgattgcctt taaattttat cagtaattgg tttcccggag aactcgagta    540

aatctagaag ttgccaggtt tcagaactat ttattccttt aatgtgcaga cgaagggaac    600

gtcatcgttt ggaaagcgtc gcaataagac gcacacgttg tgccgccgct gtggctctaa    660

ggcctaccac cttcagaagt cgacctgtgg caaatgtggc taccctgcca agcgcaagag    720

aaagtgcatg gattccgtga aggaacaaca cctaaaccca agagggcagc tgttgcagca    780

tccagttcat cttaagaatg tcaacgatta gtcatgcaat aaatgttctg gttttaaaaa    840

atacatatct ggttttggta aggtattttt aatcaattag gcttgtagta tcagtgaaat    900

actgtaggtt tagggactgg gctagcttca tatcagattt acttgttaag tgactgtttt    960

ggaatgttta cttttggact gggtttgtaa cacggttaaa ggcaatgaga aacaagcaga   1020

attccaggag tccttgaagc agagggcact ggaagacaat atagcagatt aaaatagcac   1080

agctcatgtg gcataggtgg gtattttaga tgtttgagta aatttgaaag agtatgatgt   1140

ttaaattacc tttagcaaca tgttcatctg ctatgctgtc atgactaggg ggatgattat   1200

tagtcacata gagcttggga gtaccactgg aaacgtatgg gtaggagttt aggtggcttc   1260

tgtttttcaa aagatgatct tatcctagta tctgtaatgc tcacttggca cacctgactt   1320

gtgggctgtg tgtaaggtgg ctagctaagt gaaaaaagcc tgctaggtgt gagtcaactt   1380

aagaatatgt aaataggttt gagaaaaagt agggcttggg tgcaagtaaa gattgagcag   1440

gaaataaagg aaaatcaagt ataatccctg agatttgtag actaaaggc               1489


<210>  2117
<211>  52
<212>  PRT
<213>  Homo sapiens

<400>  2117


Met Cys Arg Arg Arg Glu Arg His Arg Leu Glu Ser Val Ala Ile Arg 
1               5                   10                  15      


Arg Thr Arg Cys Ala Ala Ala Val Ala Leu Arg Pro Thr Thr Phe Arg 
            20                  25                  30          


Ser Arg Pro Val Ala Asn Val Ala Thr Leu Pro Ser Ala Arg Glu Ser 
        35                  40                  45              


Ala Trp Ile Pro 
    50          

<210>  2118
<211>  1510
<212>  DNA
<213>  Homo sapiens

<400>  2118
cagaagcgag atggtgagtt gtgactgtgg tgtttgtgaa tcgcgttcca tcctcgtcct     60

ttgtgcctct ctgtttgctg tgcttggggg gctggcaaga ttccggataa ggggaactgg    120

tgggctggaa agaggcatgc ggtggccctc aagagccaga agaatgactg ctaactggtg    180

cctgggggac ctatcccgcc gtaattgtgg tgctagagcc gcattgtgtc ctttgcctcg    240

gtccaacctt tggagacctt tcacggctct agccttggtt gggagccgag ggaaggagtt    300

tgggaatgtt tggctctgtg taacaatgaa ataattcatt ggtgatgctc tctggccgga    360

gtctgtaaag ataaggtgca tttcagaaca ttgcaactct tgcggagggt tttaggtaac    420

gtgaaatgcg ggtagtggtc tctgacttgg cattcgtgga aagaggcttc tcccgcagtt    480

tcgatcttta cgattgcctt taaattttat cagtaattgg tttcccggag aactcgagta    540

aatctagaag ttgccaggtt tcagaactat ttattccttt aatgtgcaga cgaagggaac    600

gtcatcgttt ggaaagcgtc gcaataagac gcacacgttg tgccgccgct gtggctctaa    660

ggcctaccac cttcagaagt cgacctgtgg caaatgtggc taccctgcca agcgcaagag    720

aaagtataac tggagtgcca aggctaaaag acgaaatacc accggaaaac acctaaaccc    780

aagagggcag ctgttgcagc atccagttca tcttaagaat gtcaacgatt agtcatgcaa    840

taaatgttct ggttttaaaa aatacatatc tggttttggt aaggtatttt taatcaatta    900

ggcttgtagt atcagtgaaa tactgtaggt ttagggactg ggctagcttc atatcagatt    960

tacttgttaa gtgactgttt tggaatgttt acttttggac tgggtttgta acacggttaa   1020

aggcaatgag aaacaagcag aattccagga gtccttgaag cagagggcac tggaagacaa   1080

tatagcagat taaaatagca cagctcatgt ggcataggtg ggtattttag atgtttgagt   1140

aaatttgaaa gagtatgatg tttaaattac ctttagcaac atgttcatct gctatgctgt   1200

catgactagg gggatgatta ttagtcacat agagcttggg agtaccactg gaaacgtatg   1260

ggtaggagtt taggtggctt ctgtttttca aaagatgatc ttatcctagt atctgtaatg   1320

ctcacttggc acacctgact tgtgggctgt gtgtaaggtg gctagctaag tgaaaaaagc   1380

ctgctaggtg tgagtcaact taagaatatg taaataggtt tgagaaaaag tagggcttgg   1440

gtgcaagtaa agattgagca ggaaataaag gaaaatcaag tataatccct gagatttgta   1500

gactaaaggc                                                          1510


<210>  2119
<211>  64
<212>  PRT
<213>  Homo sapiens

<400>  2119


Met Cys Arg Arg Arg Glu Arg His Arg Leu Glu Ser Val Ala Ile Arg 
1               5                   10                  15      


Arg Thr Arg Cys Ala Ala Ala Val Ala Leu Arg Pro Thr Thr Phe Arg 
            20                  25                  30          


Ser Arg Pro Val Ala Asn Val Ala Thr Leu Pro Ser Ala Arg Glu Ser 
        35                  40                  45              


Ile Thr Gly Val Pro Arg Leu Lys Asp Glu Ile Pro Pro Glu Asn Thr 
    50                  55                  60                  

<210>  2120
<211>  1066
<212>  DNA
<213>  Homo sapiens

<400>  2120
ctgggcggaa gcttctgagc gtgatatagc ggaagtgcct tctcttccgg tctttctggt     60

ctcggccgca gaagcgagat gacgaaggga acgtcatcgt ttggaaagcg tcgcaataag    120

acgcacacgt tgtgccgccg ctgtggctct aaggcctacc accttcagaa gtcgacctgt    180

ggcaaatgtg gctaccctgc caagcgcaag agaaagtata actggagtgc caaggctaaa    240

agacgaaata ccaccggaac tggtcgaatg aggcacctaa aaattgtata ccgcagattc    300

aggcatggat tccgtgaagg aacaacacct aaacccaaga gggcagctgt tgcagcatcc    360

agttcatctt aagaatgtca acgattagtc atgcaataaa tgttctggtt ttaaaaaata    420

catatctggt tttggtaagg tatttttaat caattaggct tgtagtatca gtgaaatact    480

gtaggtttag ggactgggct agcttcatat cagatttact tgttaagtga ctgttttgga    540

atgtttactt ttggactggg tttgtaacac ggttaaaggc aatgagaaac aagcagaatt    600

ccaggagtcc ttgaagcaga gggcactgga agacaatata gcagattaaa atagcacagc    660

tcatgtggca taggtgggta ttttagatgt ttgagtaaat ttgaaagagt atgatgttta    720

aattaccttt agcaacatgt tcatctgcta tgctgtcatg actaggggga tgattattag    780

tcacatagag cttgggagta ccactggaaa cgtatgggta ggagtttagg tggcttctgt    840

ttttcaaaag atgatcttat cctagtatct gtaatgctca cttggcacac ctgacttgtg    900

ggctgtgtgt aaggtggcta gctaagtgaa aaaagcctgc taggtgtgag tcaacttaag    960

aatatgtaaa taggtttgag aaaaagtagg gcttgggtgc aagtaaagat tgagcaggaa   1020

ataaaggaaa atcaagtata atccctgaga tttgtagact aaaggc                  1066


<210>  2121
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  2121


Met Thr Lys Gly Thr Ser Ser Phe Gly Lys Arg Arg Asn Lys Thr His 
1               5                   10                  15      


Thr Leu Cys Arg Arg Cys Gly Ser Lys Ala Tyr His Leu Gln Lys Ser 
            20                  25                  30          


Thr Cys Gly Lys Cys Gly Tyr Pro Ala Lys Arg Lys Arg Lys Tyr Asn 
        35                  40                  45              


Trp Ser Ala Lys Ala Lys Arg Arg Asn Thr Thr Gly Thr Gly Arg Met 
    50                  55                  60                  


Arg His Leu Lys Ile Val Tyr Arg Arg Phe Arg His Gly Phe Arg Glu 
65                  70                  75                  80  


Gly Thr Thr Pro Lys Pro Lys Arg Ala Ala Val Ala Ala Ser Ser Ser 
                85                  90                  95      


Ser 
    

<210>  2122
<211>  521
<212>  DNA
<213>  Homo sapiens

<400>  2122
gatggtgagt tgtgactgtg gtgtttgtga atcgcgttcc atcctcgtcc tttgtgcctc     60

tctgtttgct gtgcttgggg ggctggcaag attccggata aggggaactg gtgggctgga    120

aagaggcatg cggtggccct caagagccag aagaatgact gctaactgac gaagggaacg    180

tcatcgtttg gaaagcgtcg caataagacg cacacgttgt gccgccgctg tggctctaag    240

gcctaccacc ttcagaagtc gacctgtggc aaatgtggct accctgccaa gcgcaagaga    300

aagtataact ggagtgccaa ggctaaaaga cgaaatacca ccggaactgg tcgaatgagg    360

cacctaaaaa ttgtataccg cagattcagg catggattcc gtgaaggaac aacacctaaa    420

cccaagaggg cagctgttgc agcatccagt tcatcttaag aatgtcaacg attagtcatg    480

caataaatgt tctggtttta aaaaatacat atctggtttt g                        521


<210>  2123
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  2123


Met Arg His Leu Lys Ile Val Tyr Arg Arg Phe Arg His Gly Phe Arg 
1               5                   10                  15      


Glu Gly Thr Thr Pro Lys Pro Lys Arg Ala Ala Val Ala Ala Ser Ser 
            20                  25                  30          


Ser Ser 
        

<210>  2124
<211>  506
<212>  DNA
<213>  Homo sapiens

<400>  2124
ctcttgaccc cacctacact acgacgacgg acgctcgaga acgctgcacc gcgccccgca     60

ggaagtgctt ccctgggcgg aagcttctga gcgtgatata gcggaagtgc cttctcttcc    120

ggtctttctg gtctcggccg cagaagcgag atgacgaagg gaacgtcatc gtttggaaag    180

cgtcgcaata agacgcacac gttgtgccgc cgctgtggct ctaaggccta ccaccttcag    240

aagtcgacct gtggcaaatg tggctaccct gccaagcgca agagaaagta taactggagt    300

gccaaggcta aaagacgaaa taccaccgga actggtcgaa tgaggcacct aaaaattgta    360

taccgcagat tcaggcatgg attccgtgaa ggaacaacac ctaaacccaa gagggcagct    420

gttgcagcat ccagttcatc ttaagaatgt caacgattag tcatgcaata aatgttctgg    480

ttttaaaaaa tacatatctg gttttg                                         506


<210>  2125
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  2125


Met Thr Lys Gly Thr Ser Ser Phe Gly Lys Arg Arg Asn Lys Thr His 
1               5                   10                  15      


Thr Leu Cys Arg Arg Cys Gly Ser Lys Ala Tyr His Leu Gln Lys Ser 
            20                  25                  30          


Thr Cys Gly Lys Cys Gly Tyr Pro Ala Lys Arg Lys Arg Lys Tyr Asn 
        35                  40                  45              


Trp Ser Ala Lys Ala Lys Arg Arg Asn Thr Thr Gly Thr Gly Arg Met 
    50                  55                  60                  


Arg His Leu Lys Ile Val Tyr Arg Arg Phe Arg His Gly Phe Arg Glu 
65                  70                  75                  80  


Gly Thr Thr Pro Lys Pro Lys Arg Ala Ala Val Ala Ala Ser Ser Ser 
                85                  90                  95      


Ser 
    

<210>  2126
<211>  945
<212>  DNA
<213>  Homo sapiens

<400>  2126
ctttctggtc tcggccgcag aagcgagatg gtgagttgtg actgtggtgt ttgtgaatcg     60

cgttccatcc tcgtcctttg tgcctctctg tttgctgtgc ttggggggct ggcaagattc    120

cggataaggg gaactggtgg gctggaaaga ggcatgcggt ggccctcaag agccagaaga    180

atgactgcta actggtgcct gggggaccta tcccgccgta attgtggtgc tagagccgca    240

ttgtgtcctt tgcctcggtc caacctttgg agacctttca cggctctagc cttggttggg    300

agccgaggga aggagtttgg gaatgtttgg ctctgtgtaa caatgaaata attcattggt    360

gatgctctct ggccggagtc tgtaaagata aggtgcattt cagaacattg caactcttgc    420

ggagggtttt aggtaacgtg aaatgcgggt agtggtctct gacttggcat tcgtggaaag    480

aggcttctcc cgcagtttcg atctttacga ttgcctttaa attttatcag taattggttt    540

cccggagaac tcgagtaaat ctagaagttg ccaggtttca gaactattta ttcctttaat    600

gtgcagacga agggaacgtc atcgtttgga aagcgtcgca ataagacgca cacgttgtgc    660

cgccgctgtg gctctaaggc ctaccacctt cagaagtcga cctgtggcaa atgtggctac    720

cctgccaagc gcaagagaaa gtataactgg agtgccaagg ctaaaagacg aaataccacc    780

ggaactggtc gaatgaggca cctaaaaatt gtataccgca gattcaggca tggattccgt    840

gaaggaacaa cacctaaacc caagagggca gctgttgcag catccagttc atcttaagaa    900

tgtcaacgat tagtcatgca ataaatgttc tggttttaaa aaata                    945


<210>  2127
<211>  65
<212>  PRT
<213>  Homo sapiens

<400>  2127


Met Cys Arg Arg Arg Glu Arg His Arg Leu Glu Ser Val Ala Ile Arg 
1               5                   10                  15      


Arg Thr Arg Cys Ala Ala Ala Val Ala Leu Arg Pro Thr Thr Phe Arg 
            20                  25                  30          


Ser Arg Pro Val Ala Asn Val Ala Thr Leu Pro Ser Ala Arg Glu Ser 
        35                  40                  45              


Ile Thr Gly Val Pro Arg Leu Lys Asp Glu Ile Pro Pro Glu Leu Val 
    50                  55                  60                  


Glu 
65  

<210>  2128
<211>  1213
<212>  DNA
<213>  Homo sapiens

<400>  2128
cagaagcgag atggtgagtt gtgactgtgg tgtttgtgaa tcgcgttcca tcctcgtcct     60

ttgtgcctct ctgtttgctg tgcttggggg gctggcaaga ttccggataa ggggaactgg    120

tgggctggaa agaggcatgc ggtggccctc aagagccaga agaatgactg ctaactggtg    180

cctgggggac ctatcccgcc gtaattgtgg tgctagagcc gcattgtgtc ctttgcctcg    240

gtccaacctt tggagacctt tcacggctct agccttggtt gggagccgag ggaaggagtt    300

tgggaatgtt tggctctgtg taacaatgaa ataattcatt ggtgatgctc tctggccgga    360

gtctgtaaag ataaggtgca tttcagaaca ttgcaactct tgcggagggt tttaggtaac    420

gtgaaatgcg ggtagtggtc tctgacttgg cattcgtgga aagaggcttc tcccgcagtt    480

tcgatcttta cgattgcctt taaattttat cagtaattgg tttcccggag aactcgagta    540

aatctagaag ttgccaggtt tcagaactat ttattccttt aatgtgcaga cgaagggaac    600

gtcatcgttt ggaaagcgtc gcaataagac gcacacgttg tgccgccgct gtggctctaa    660

ggcctaccac cttcagaagt cgacctgtgg caaatgtggc taccctgcca agcgcaagag    720

aaagtataac tggagtgcca aggctaaaag acgaaatacc accggaactg gtcgaatgag    780

gcacctaaaa attgtatacc gcagattcag gtacagtttg tatgttcgat cataattggt    840

ccagtgggct tgaatgaaac cctcgtgttt acttgtaaaa agataacagt accctgatgg    900

ttactgggga tgagatgttg gaagcttttt atttattgtt gtttttgagg cagggtttca    960

ctatgttgcc caggcttgag tgtagtggca cgatcacggc tcagtgcagc ctcagtctcc   1020

ccagcctcag gtaatctcat ctcagccgcc cgagtacccg ggactacagg tgtgcgctgc   1080

cacatgccca gctaattttt gtatttattg tagagaatgg gatattgtca tgttacccag   1140

gataatctcg gaactcctgg gctcaggcca gatgttgaaa gcttttatct tctgccgctg   1200

taaccttgac atc                                                      1213


<210>  2129
<211>  65
<212>  PRT
<213>  Homo sapiens

<400>  2129


Met Cys Arg Arg Arg Glu Arg His Arg Leu Glu Ser Val Ala Ile Arg 
1               5                   10                  15      


Arg Thr Arg Cys Ala Ala Ala Val Ala Leu Arg Pro Thr Thr Phe Arg 
            20                  25                  30          


Ser Arg Pro Val Ala Asn Val Ala Thr Leu Pro Ser Ala Arg Glu Ser 
        35                  40                  45              


Ile Thr Gly Val Pro Arg Leu Lys Asp Glu Ile Pro Pro Glu Leu Val 
    50                  55                  60                  


Glu 
65  

<210>  2130
<211>  4210
<212>  DNA
<213>  Homo sapiens

<400>  2130
ccggatcaga gagtgctccg agctgggttg ccccactgtg cttgtatctg cactctccaa     60

cactaggcat cattgacatg ttaaagctta gccaaataga attgttcttt gtcattcttt    120

ttttaacttt tacttattca ttaggatgat ttcataatat atttcctggt ttagaggaaa    180

caggaacaat ggctaccgag agtactccct cagagatcat agaaagagaa agaaaaaagt    240

tgcttgaaat ccttcaacat gatcctgatt ctatcttaga cacgttaact tctcggaggc    300

tgatttctga ggaagagtat gagactctgg agaatgttac agatctcctg aagaaaagtc    360

ggaagctgtt aattttggta cagaaaaagg gagaggcgac ctgtcagcat tttctcaagt    420

gtttatttag tacttttcca cagtcagctg ccatttgcgg cttaaggcat gaagttttaa    480

aacatgagaa tacagtacct cctcaatcta tgggggcaag cagtaattca gaagatgctt    540

tttctcctgg aataaaacag cctgaagccc ctgagatcac agtgttcttc agtgagaagg    600

aacacttgga tttggaaacc tctgagtttt tcagggacaa gaaaactagt tatagggaaa    660

cagctttgtc tgccaggaag aatgagaagg aatatgacac accagaagtc acattatcat    720

attcagttga gaaagttgga tgtgaagttc cagcaactat tacatatata aaagatggac    780

agagatatga ggagctagat gattctttat acttaggaaa agaggaatat ctaggatctg    840

ttgacacccc tgaagatgca gaagccactg tggaagagga ggtttatgat gacccagagc    900

acgttggata tgatggtgaa gaggacttcg agaattcaga aaccacagag ttctctggtg    960

aagaaccaag ttatgaggga tcagaaacca gcctttcatt ggaggaggaa caggagaaaa   1020

gtatagaaga aagaaaaaag gtgtttaaag atgtcctgtt atgtttgaac atggatagaa   1080

gcagaaaggt tctgccagat tttgttaaac aattctcctt agatcgagga tgtaagtgga   1140

cccctgagag tccaggagac ttagcctgga atttcctgat gaaagttcaa gcacgagatg   1200

tgaccgctag ggattcaatc ctcagtcaca aggttctgga tgaagatagc aaggaggatt   1260

tgctggctgg agtggagaat ttggaaattc gagacataca aaccattaat ccccttgacg   1320

tgctttgtgc caccatgctg tgttcagata gctctttgca acgccaagtc atgtcaaaca   1380

tgtatcagtg ccagtttgct cttcccctgc tactgccaga tgcagaaaac aacaaaagca   1440

tcttaatgct gggggccatg aaagacattg tgaagaagca gtcaacacag ttttcagggg   1500

ggcctacaga ggatacagaa aagtttctga ctctcatgaa gatgcctgtc atctcttttg   1560

tgcgtctagg atactgtagc ttctctaagt ccagaatcct caacacactt ctcagccctg   1620

cccagttgaa attacacaaa atctttcttc atcaagattt gcctcttttg gtgcttcccc   1680

ggcaaatctc tgatggcctg gttgagataa catggtgttt tcctgatagc gatgatagaa   1740

aggaaaaccc ctttttccaa aagcctgttg ctctggctaa tctccgtgga aatctagaaa   1800

gcttttggac tcagtttggt tttttgatgg aagtttcttc agctgtgttt tttttcactg   1860

actgtttagg tgagaaggaa tgggacttgc taatgttttt aggagaggct gccattgaaa   1920

gatgctactt tgttctcagt tcccaagcca gggagagtga agaggctcaa atttttcaga   1980

ggatactgaa cttgaagcca gcacagctac tgttttggga gaggggagat gctggggata   2040

gaaggaagaa catggagggc cttcaagctg ccctccagga agtgatgttc tcttcttgcc   2100

tcagatgtgt gtctgtggag gatatggccg ccctggccag ggagctgggg attcaggtag   2160

atgaagactt tgaaaacact cagagaattc aagtttcctc tggagaaaac atggctggga   2220

cagctgaagg tgagggtcag caaagacaca gtcagctaaa aagctcatct aaaagccagg   2280

ctctaatgcc aattcaagag cctgggactc aatgtgagct cagccagaat cttcagaatc   2340

tctatggtac cccagtattc aggcctgttc tagagaactc ctggctcttt ccaaccagaa   2400

ttggaggtaa ctttaaccat gtttccttga aagcctcctg ggttatgggc cgcccctttg   2460

ggtcagagca gaggcctaag tggttccatc ctttgccttt tcagaatgca ggggcccagg   2520

gccgaggtaa aagttttggt attcaatcct tccatcccca gatattttat tcaggtgaaa   2580

gattcatgaa attttccaga gttgctcggg gatgtcactc gaatggaaca tttgggagac   2640

tgccaagacc catttgtcag catgtacagg cctgccctga gagaccacaa atgatgggaa   2700

ctcttgaaag gtctagggca gtagcctcca agataggtca ctcctattcc ctggattcac   2760

agccagcaag agcagtaggg aagccatggc ctcagcaagc ttgcaccagg gtaacagagt   2820

taactgaagc aactggaaaa ctgataagaa catcccatat tggaaagcct caccctcagt   2880

cctttcaacc agcagcagcc acacaaaaac taagacctgc ttctcagcaa ggagtccaga   2940

tgaagacaca aggtggggct tcaaatccag ctctccaaat agggtcccat cccatgtgca   3000

agagctctca gttcaaatcc gatcagtcca acccatccac agtcaaacac tcccagccta   3060

aacccttcca ttctgtgccc tctcaaccta aatcctctca gacaaaatcc tgtcagtccc   3120

agccctccca aactaaacct tctccatgca aatctactca gcctaagcca agccagccct   3180

ggcctcccca gtctaagcct tctcagccca gaccccctca acctaagtca tcctcaacca   3240

atccttcaca agctaaggca caccactcaa aagcagggca gaagagggga gggaagcatt   3300

aaagagctaa ctccagagat ctataaagca tatcctttac ccaggccatt cctatcatat   3360

agtaagcaga agagttgcca tgaaagtaaa agactactgt cattagcatg taaaacaaag   3420

aaagatatac atgactgaat tggatatctt tgtttgtttg tttgagacag agtttcactc   3480

ttgttgccca ggctggagtg caatggcacg atctcggctc accgcaacct ctgcttcctg   3540

gcttaaagtg attctcctgc ctcagcctct cgagtagctg ggattacagg catgcaccac   3600

cacacccagc taattttgta tttttagtag aggcagggtt tctccatgtt ggtcaggctg   3660

gtcttgaact cccgacctca ggtgatccgc ccacctaggc ctctcaaagt gttgggatta   3720

cgtgtgtaag ccacagtgcc cagcccgaat tggatatctt taagatatct gtaagtgtta   3780

tatccctaac caagaagaaa aatatgaaaa taattaagac tagaatcaag cagtagataa   3840

ttgaatccaa tcttgggtat tattagataa tgtataactt gcacccaggg aatgggggtc   3900

tatgagacaa ccccacttgg agaagaatgg ggttagggtc tctaattgca aagtgactgt   3960

acaataggac gaaagttgcc tctgtgtctg agaaagtatc ttagttgttg gctgctccag   4020

aggtatcttt gtcaaaagct tctggttcaa tatcagccac tgagcagata accctgctta   4080

tttggtgtgg ttaaatcaac tagcttctgc taatagcccc aatttgcttg aatgggaaaa   4140

ctctctcatt tgacccttat aggtagaaat aatgaattaa caaccaataa aattaatcat   4200

ttggcattaa                                                          4210


<210>  2131
<211>  1037
<212>  PRT
<213>  Homo sapiens

<400>  2131


Met Ala Thr Glu Ser Thr Pro Ser Glu Ile Ile Glu Arg Glu Arg Lys 
1               5                   10                  15      


Lys Leu Leu Glu Ile Leu Gln His Asp Pro Asp Ser Ile Leu Asp Thr 
            20                  25                  30          


Leu Thr Ser Arg Arg Leu Ile Ser Glu Glu Glu Tyr Glu Thr Leu Glu 
        35                  40                  45              


Asn Val Thr Asp Leu Leu Lys Lys Ser Arg Lys Leu Leu Ile Leu Val 
    50                  55                  60                  


Gln Lys Lys Gly Glu Ala Thr Cys Gln His Phe Leu Lys Cys Leu Phe 
65                  70                  75                  80  


Ser Thr Phe Pro Gln Ser Ala Ala Ile Cys Gly Leu Arg His Glu Val 
                85                  90                  95      


Leu Lys His Glu Asn Thr Val Pro Pro Gln Ser Met Gly Ala Ser Ser 
            100                 105                 110         


Asn Ser Glu Asp Ala Phe Ser Pro Gly Ile Lys Gln Pro Glu Ala Pro 
        115                 120                 125             


Glu Ile Thr Val Phe Phe Ser Glu Lys Glu His Leu Asp Leu Glu Thr 
    130                 135                 140                 


Ser Glu Phe Phe Arg Asp Lys Lys Thr Ser Tyr Arg Glu Thr Ala Leu 
145                 150                 155                 160 


Ser Ala Arg Lys Asn Glu Lys Glu Tyr Asp Thr Pro Glu Val Thr Leu 
                165                 170                 175     


Ser Tyr Ser Val Glu Lys Val Gly Cys Glu Val Pro Ala Thr Ile Thr 
            180                 185                 190         


Tyr Ile Lys Asp Gly Gln Arg Tyr Glu Glu Leu Asp Asp Ser Leu Tyr 
        195                 200                 205             


Leu Gly Lys Glu Glu Tyr Leu Gly Ser Val Asp Thr Pro Glu Asp Ala 
    210                 215                 220                 


Glu Ala Thr Val Glu Glu Glu Val Tyr Asp Asp Pro Glu His Val Gly 
225                 230                 235                 240 


Tyr Asp Gly Glu Glu Asp Phe Glu Asn Ser Glu Thr Thr Glu Phe Ser 
                245                 250                 255     


Gly Glu Glu Pro Ser Tyr Glu Gly Ser Glu Thr Ser Leu Ser Leu Glu 
            260                 265                 270         


Glu Glu Gln Glu Lys Ser Ile Glu Glu Arg Lys Lys Val Phe Lys Asp 
        275                 280                 285             


Val Leu Leu Cys Leu Asn Met Asp Arg Ser Arg Lys Val Leu Pro Asp 
    290                 295                 300                 


Phe Val Lys Gln Phe Ser Leu Asp Arg Gly Cys Lys Trp Thr Pro Glu 
305                 310                 315                 320 


Ser Pro Gly Asp Leu Ala Trp Asn Phe Leu Met Lys Val Gln Ala Arg 
                325                 330                 335     


Asp Val Thr Ala Arg Asp Ser Ile Leu Ser His Lys Val Leu Asp Glu 
            340                 345                 350         


Asp Ser Lys Glu Asp Leu Leu Ala Gly Val Glu Asn Leu Glu Ile Arg 
        355                 360                 365             


Asp Ile Gln Thr Ile Asn Pro Leu Asp Val Leu Cys Ala Thr Met Leu 
    370                 375                 380                 


Cys Ser Asp Ser Ser Leu Gln Arg Gln Val Met Ser Asn Met Tyr Gln 
385                 390                 395                 400 


Cys Gln Phe Ala Leu Pro Leu Leu Leu Pro Asp Ala Glu Asn Asn Lys 
                405                 410                 415     


Ser Ile Leu Met Leu Gly Ala Met Lys Asp Ile Val Lys Lys Gln Ser 
            420                 425                 430         


Thr Gln Phe Ser Gly Gly Pro Thr Glu Asp Thr Glu Lys Phe Leu Thr 
        435                 440                 445             


Leu Met Lys Met Pro Val Ile Ser Phe Val Arg Leu Gly Tyr Cys Ser 
    450                 455                 460                 


Phe Ser Lys Ser Arg Ile Leu Asn Thr Leu Leu Ser Pro Ala Gln Leu 
465                 470                 475                 480 


Lys Leu His Lys Ile Phe Leu His Gln Asp Leu Pro Leu Leu Val Leu 
                485                 490                 495     


Pro Arg Gln Ile Ser Asp Gly Leu Val Glu Ile Thr Trp Cys Phe Pro 
            500                 505                 510         


Asp Ser Asp Asp Arg Lys Glu Asn Pro Phe Phe Gln Lys Pro Val Ala 
        515                 520                 525             


Leu Ala Asn Leu Arg Gly Asn Leu Glu Ser Phe Trp Thr Gln Phe Gly 
    530                 535                 540                 


Phe Leu Met Glu Val Ser Ser Ala Val Phe Phe Phe Thr Asp Cys Leu 
545                 550                 555                 560 


Gly Glu Lys Glu Trp Asp Leu Leu Met Phe Leu Gly Glu Ala Ala Ile 
                565                 570                 575     


Glu Arg Cys Tyr Phe Val Leu Ser Ser Gln Ala Arg Glu Ser Glu Glu 
            580                 585                 590         


Ala Gln Ile Phe Gln Arg Ile Leu Asn Leu Lys Pro Ala Gln Leu Leu 
        595                 600                 605             


Phe Trp Glu Arg Gly Asp Ala Gly Asp Arg Arg Lys Asn Met Glu Gly 
    610                 615                 620                 


Leu Gln Ala Ala Leu Gln Glu Val Met Phe Ser Ser Cys Leu Arg Cys 
625                 630                 635                 640 


Val Ser Val Glu Asp Met Ala Ala Leu Ala Arg Glu Leu Gly Ile Gln 
                645                 650                 655     


Val Asp Glu Asp Phe Glu Asn Thr Gln Arg Ile Gln Val Ser Ser Gly 
            660                 665                 670         


Glu Asn Met Ala Gly Thr Ala Glu Gly Glu Gly Gln Gln Arg His Ser 
        675                 680                 685             


Gln Leu Lys Ser Ser Ser Lys Ser Gln Ala Leu Met Pro Ile Gln Glu 
    690                 695                 700                 


Pro Gly Thr Gln Cys Glu Leu Ser Gln Asn Leu Gln Asn Leu Tyr Gly 
705                 710                 715                 720 


Thr Pro Val Phe Arg Pro Val Leu Glu Asn Ser Trp Leu Phe Pro Thr 
                725                 730                 735     


Arg Ile Gly Gly Asn Phe Asn His Val Ser Leu Lys Ala Ser Trp Val 
            740                 745                 750         


Met Gly Arg Pro Phe Gly Ser Glu Gln Arg Pro Lys Trp Phe His Pro 
        755                 760                 765             


Leu Pro Phe Gln Asn Ala Gly Ala Gln Gly Arg Gly Lys Ser Phe Gly 
    770                 775                 780                 


Ile Gln Ser Phe His Pro Gln Ile Phe Tyr Ser Gly Glu Arg Phe Met 
785                 790                 795                 800 


Lys Phe Ser Arg Val Ala Arg Gly Cys His Ser Asn Gly Thr Phe Gly 
                805                 810                 815     


Arg Leu Pro Arg Pro Ile Cys Gln His Val Gln Ala Cys Pro Glu Arg 
            820                 825                 830         


Pro Gln Met Met Gly Thr Leu Glu Arg Ser Arg Ala Val Ala Ser Lys 
        835                 840                 845             


Ile Gly His Ser Tyr Ser Leu Asp Ser Gln Pro Ala Arg Ala Val Gly 
    850                 855                 860                 


Lys Pro Trp Pro Gln Gln Ala Cys Thr Arg Val Thr Glu Leu Thr Glu 
865                 870                 875                 880 


Ala Thr Gly Lys Leu Ile Arg Thr Ser His Ile Gly Lys Pro His Pro 
                885                 890                 895     


Gln Ser Phe Gln Pro Ala Ala Ala Thr Gln Lys Leu Arg Pro Ala Ser 
            900                 905                 910         


Gln Gln Gly Val Gln Met Lys Thr Gln Gly Gly Ala Ser Asn Pro Ala 
        915                 920                 925             


Leu Gln Ile Gly Ser His Pro Met Cys Lys Ser Ser Gln Phe Lys Ser 
    930                 935                 940                 


Asp Gln Ser Asn Pro Ser Thr Val Lys His Ser Gln Pro Lys Pro Phe 
945                 950                 955                 960 


His Ser Val Pro Ser Gln Pro Lys Ser Ser Gln Thr Lys Ser Cys Gln 
                965                 970                 975     


Ser Gln Pro Ser Gln Thr Lys Pro Ser Pro Cys Lys Ser Thr Gln Pro 
            980                 985                 990         


Lys Pro Ser Gln Pro Trp Pro Pro  Gln Ser Lys Pro Ser  Gln Pro Arg 
        995                 1000                 1005             


Pro Pro  Gln Pro Lys Ser Ser  Ser Thr Asn Pro Ser  Gln Ala Lys 
    1010                 1015                 1020             


Ala His  His Ser Lys Ala Gly  Gln Lys Arg Gly Gly  Lys His 
    1025                 1030                 1035         

<210>  2132
<211>  5416
<212>  DNA
<213>  Homo sapiens

<400>  2132
tcacgggctc cggtcccggc ggcagaaata gggcagccgc ggcggcggtg gcacagcagc     60

gggcagcggc ggctcaggga gctggagcct caacagcctc cagcgagccc gggacccgcc    120

gacagcccga gaaaccagcc gaaggacgcg gggcggggtc gccgccgccg ccacggggtg    180

ctccctccct cccgcccaag tccggccacc tggtcttccc ctcggccccg gccgtctcag    240

actcatcaaa atgaaaccag gaggcttttg gctgcatctc acactgctcg gagcctccct    300

gccggctgcg ctgggatgga tggacccagg aaccagcaga ggcccggatg tgggtgtggg    360

ggagtcacag gcagaggagc ccagaagctt tgaagtcaca agaagagaag ggctttccag    420

ccacaacgag ctgctggcct cctgcgggaa gaagttctgc agccgaggga gccggtgcgt    480

gctcagcagg aagacagggg agcccgaatg ccagtgcctg gaggcatgca ggcccagcta    540

cgtgcctgtg tgcggctctg atgggaggtt ttatgaaaac cactgtaagc tccaccgtgc    600

tgcttgcctc ctgggaaaga ggatcaccgt catccacagc aaggactgtt tcctcaaagg    660

tgacacgtgc accatggccg gctacgcccg cttgaagaat gtccttctgg cactccagac    720

ccgtctgcag ccactccaag aaggagacag cagacaagac cctgcctccc agaagcgcct    780

cctggtggaa tctctgttca gggacttaga tgcagatggc aatggccacc tcagcagctc    840

cgaactggct cagcatgtgc tgaagaagca ggacctggat gaagacttac ttggttgctc    900

accaggtgac ctcctccgat ttgacgatta caacagtgac agctccctga ccctccgcga    960

gttctacatg gccttccaag tggttcagct cagcctcgcc cccgaggaca gggtcagtgt   1020

gaccacagtg accgtggggc tgagcacagt gctgacctgc gccgtccatg gagacctgag   1080

gccaccaatc atctggaagc gcaacgggct caccctgaac ttcctggact tggaagacat   1140

caatgacttt ggagaggatg attccctgta catcaccaag gtgaccacca tccacatggg   1200

caattacacc tgccatgctt ccggccacga gcagctgttc cagacccacg tcctgcaggt   1260

gaatgtgccg ccagtcatcc gtgtctatcc agagagccag gcacaggagc ctggagtggc   1320

agccagccta agatgccatg ctgagggcat tcccatgccc agaatcactt ggctgaaaaa   1380

cggcgtggat gtctcaactc agatgtccaa acagctctcc cttttagcca atgggagcga   1440

actccacatc agcagtgttc ggtatgaaga cacaggggca tacacctgca ttgccaaaaa   1500

tgaagtgggt gtggatgaag atatctcctc gctcttcatt gaagactcag ctagaaagac   1560

ccttgcaaac atcctgtggc gagaggaagg cctcagcgtg ggaaacatgt tctatgtctt   1620

ctccgacgac ggtatcatcg tcatccatcc tgtggactgt gagatccaga ggcacctcaa   1680

acccacggaa aagattttca tgagctatga agaaatctgt cctcaaagag aaaaaaatgc   1740

aacccagccc tgccagtggg tatctgcagt caatgtccgg aaccggtaca tctatgtggc   1800

ccagccagca ctgagcagag tccttgtggt cgacatccaa gcccagaaag tcctacagtc   1860

cataggtgtg gaccctctgc cggctaagct gtcctatgac aagtcacatg accaagtgtg   1920

ggtcctgagc tggggggacg tgcacaagtc ccgaccaagt ctccaggtga tcacagaagc   1980

cagcaccggc cagagccagc acctcatccg cacacccttt gcaggagtgg atgatttctt   2040

cattccccca acaaacctca tcatcaacca catcaggttt ggcttcatct tcaacaagtc   2100

tgatcctgca gtccacaagg tggacctgga aacaatgatg cccctcaaga ccatcggcct   2160

gcaccaccat ggctgcgtgc cccaggccat ggcacacacc cacctgggcg gctacttctt   2220

catccagtgc cgacaggaca gccccgcctc tgctgcccga cagctgctcg ttgacagtgt   2280

cacagactct gtgcttggcc ccaatggtga tgtaacaggc accccacaca catcccccga   2340

cgggcgcttc atagtcagtg ctgcagctga cagcccctgg ctgcacgtgc aggagatcac   2400

agtgcggggc gagatccaga ccctgtatga cctgcaaata aactcgggca tctcagactt   2460

ggccttccag cgctccttca ctgaaagcaa tcaatacaac atctacgcgg ctctgcacac   2520

ggagccggac ctgctgttcc tggagctgtc cacggggaag gtgggcatgc tgaagaactt   2580

aaaggagcca cccgcagggc cagctcagcc ctgggggggt acccacagaa tcatgaggga   2640

cagtgggctg tttggacagt acctcctcac accagcccga gagtcactgt tcctcatcaa   2700

tgggagacaa aacacgctgc ggtgtgaggt gtcaggtata aaggggggga ccacagtggt   2760

gtgggtgggt gaggtatgaa gggcccagag cagagccctg ggccaaggaa caccccctag   2820

tcctgacact gcagcctcaa gcaggtacgc tgtacatttt tacagacaaa agcaaaaacc   2880

tgtactcgct ttgtggttca acactggtct ccttgcaagt ttcctagtat aaggtatgcg   2940

ctgctaccaa gattggggtt ttttcgttag gaagtatgat ttatgccttg agctacgatg   3000

agaacatatg ctgctgtgta aagggatcat ttctgtgcca agctgcacac cgagtgacct   3060

ggggacatca tggaaccaag ggatcctgct ctccaagcag acacctctgt cagttgcctt   3120

cacatagtca ttgtccctta ctgccagacc cagccagact ttgccctgac ggagtggccc   3180

ggaagcagag gctgaccagg agcaggggcc tccctcccga actgaaagcc catccgtcct   3240

cgcgtgggac cgcatcttct ccctcgcagc tgcttcttgc ttttctttcc atttgacttg   3300

ctgtaagcct gagggagagc caacaagact tactgcatct tgggggatgg ggaaatcact   3360

cactttattt tggaaatttt tgattaaaaa aaaattttat aatctcaaat gctagtaagc   3420

agaaagatgc tctccgaggt ccaactatat ccttccctgc cttaggccga gtctcggggg   3480

tggtcacaac cccacatccc acagccagaa agaacaatgg tcatctgaga atactggccc   3540

tgtcgactat tgccaccctg cttctccaag agcagaccag gccacctcat ccgtaaggac   3600

tcggttctgt gttgggaccc caaaaaacca gaacaagttc tgtgtgcctc ctttcagcac   3660

agaagggaga catctcatta gtcaggtctg gtaccccaga ttcagggcag actgggcttg   3720

cctggcaagg tatgggtggc ctccaggctc aatgcagaaa ccccaaggac acgagtgggg   3780

ccaggtgagt tcctgaagct ataccttttc aaaacagatt ttgttttcct acctgtggcc   3840

catccactcc tctctggtac cccatccccg catcagcact gcagagagaa cacatttcgg   3900

cgagggtttt cttacccaca ttccccaatc aatacacaca cactgcagaa cccagaacag   3960

aaggccacag gctggcacta ctgcattctc cttatgtgtc tcaggctgtg gtgactctca   4020

catgggcatc gaagaagtac aacccacata gccctctgga gaccgcctag atcagagact   4080

cagcaaaaac aggctcgcct tccctctccc acatatgagt ggaacttaca tgtgtcctgg   4140

tttgaatgat cattttgcaa gccacacggg ttgggagagg tggtctcacc acagacgtct   4200

ttgctaattt ggccaccttc acctactgac atgaccagga ttttcctttg ccattaagga   4260

atgaactctt tcaaggagag gaaaccctag actctgtgtc actctcaaca cacacagctc   4320

ctttcactcc tgcctgactg ccaagccacc tgcatccccc gccccagatc tcatgagatc   4380

aatcacttgt atgtctcacg caacttggtc caccaaacgc ctgtcccctg taactcctag   4440

gggtgcgcct agacaggtac gtctgttttt tattttaaaa gatatgctat gtagatataa   4500

gttgaggaag ctcacctcaa aagcctagaa tgcagtttca cagtagctgg gatgcatgga   4560

tgacccatct cacccctttt tttttcctgc ctcaatatct tgatatgtta tgtttactcc   4620

caatctccca tttttaccac taaaattctc caactttcat aaactttttt ttggaaaaat   4680

ttccattgta tcagcccctg acagaaaaag gatctctgag cctaaaggag gaaaagtccc   4740

accaactacc agaccagaac acgagcccct ctgggcagca ggattcctaa gtcaaagacc   4800

agtttgaccc aaactggcct tttaaaataa tcaggagtga cagagtcaac ttctgcagca   4860

cctgcttctc ccccactgtc ccttccatct tggaatgtgt ctaaaaaagc atagctgccc   4920

tttgctgtcc tcagagtgca tttcctggag acggcaggct taggtctcac tgacagcatg   4980

ccagacacaa ctgaatcgaa gcaggcctga agcctaggtc agggtttcag gagtccagcc   5040

ccaggaggca aagtcaccaa tgcagggagg taaatgcctt ttggcaggaa aaccaataga   5100

gttggttggg tggggagtca ggggtgggag gagaaggagg aagaggagga aggccagact   5160

ggcctgccct ttctcccata cttcacccca gcagaggttc atgggacaca gttggaaagc   5220

cactgggagg aaatgcctca ctacaggggg gcctcctgta gcaagcccag ccggtaatcc   5280

tcctaatgaa cccacaaggt caattcacaa ctgatatctt agctattaaa gaagtactga   5340

ctttaccaaa agaatcatca agaaagctat ttatataaac cccctcagtc attttgaaat   5400

aaaattaatt ttacaa                                                   5416


<210>  2133
<211>  842
<212>  PRT
<213>  Homo sapiens

<400>  2133


Met Lys Pro Gly Gly Phe Trp Leu His Leu Thr Leu Leu Gly Ala Ser 
1               5                   10                  15      


Leu Pro Ala Ala Leu Gly Trp Met Asp Pro Gly Thr Ser Arg Gly Pro 
            20                  25                  30          


Asp Val Gly Val Gly Glu Ser Gln Ala Glu Glu Pro Arg Ser Phe Glu 
        35                  40                  45              


Val Thr Arg Arg Glu Gly Leu Ser Ser His Asn Glu Leu Leu Ala Ser 
    50                  55                  60                  


Cys Gly Lys Lys Phe Cys Ser Arg Gly Ser Arg Cys Val Leu Ser Arg 
65                  70                  75                  80  


Lys Thr Gly Glu Pro Glu Cys Gln Cys Leu Glu Ala Cys Arg Pro Ser 
                85                  90                  95      


Tyr Val Pro Val Cys Gly Ser Asp Gly Arg Phe Tyr Glu Asn His Cys 
            100                 105                 110         


Lys Leu His Arg Ala Ala Cys Leu Leu Gly Lys Arg Ile Thr Val Ile 
        115                 120                 125             


His Ser Lys Asp Cys Phe Leu Lys Gly Asp Thr Cys Thr Met Ala Gly 
    130                 135                 140                 


Tyr Ala Arg Leu Lys Asn Val Leu Leu Ala Leu Gln Thr Arg Leu Gln 
145                 150                 155                 160 


Pro Leu Gln Glu Gly Asp Ser Arg Gln Asp Pro Ala Ser Gln Lys Arg 
                165                 170                 175     


Leu Leu Val Glu Ser Leu Phe Arg Asp Leu Asp Ala Asp Gly Asn Gly 
            180                 185                 190         


His Leu Ser Ser Ser Glu Leu Ala Gln His Val Leu Lys Lys Gln Asp 
        195                 200                 205             


Leu Asp Glu Asp Leu Leu Gly Cys Ser Pro Gly Asp Leu Leu Arg Phe 
    210                 215                 220                 


Asp Asp Tyr Asn Ser Asp Ser Ser Leu Thr Leu Arg Glu Phe Tyr Met 
225                 230                 235                 240 


Ala Phe Gln Val Val Gln Leu Ser Leu Ala Pro Glu Asp Arg Val Ser 
                245                 250                 255     


Val Thr Thr Val Thr Val Gly Leu Ser Thr Val Leu Thr Cys Ala Val 
            260                 265                 270         


His Gly Asp Leu Arg Pro Pro Ile Ile Trp Lys Arg Asn Gly Leu Thr 
        275                 280                 285             


Leu Asn Phe Leu Asp Leu Glu Asp Ile Asn Asp Phe Gly Glu Asp Asp 
    290                 295                 300                 


Ser Leu Tyr Ile Thr Lys Val Thr Thr Ile His Met Gly Asn Tyr Thr 
305                 310                 315                 320 


Cys His Ala Ser Gly His Glu Gln Leu Phe Gln Thr His Val Leu Gln 
                325                 330                 335     


Val Asn Val Pro Pro Val Ile Arg Val Tyr Pro Glu Ser Gln Ala Gln 
            340                 345                 350         


Glu Pro Gly Val Ala Ala Ser Leu Arg Cys His Ala Glu Gly Ile Pro 
        355                 360                 365             


Met Pro Arg Ile Thr Trp Leu Lys Asn Gly Val Asp Val Ser Thr Gln 
    370                 375                 380                 


Met Ser Lys Gln Leu Ser Leu Leu Ala Asn Gly Ser Glu Leu His Ile 
385                 390                 395                 400 


Ser Ser Val Arg Tyr Glu Asp Thr Gly Ala Tyr Thr Cys Ile Ala Lys 
                405                 410                 415     


Asn Glu Val Gly Val Asp Glu Asp Ile Ser Ser Leu Phe Ile Glu Asp 
            420                 425                 430         


Ser Ala Arg Lys Thr Leu Ala Asn Ile Leu Trp Arg Glu Glu Gly Leu 
        435                 440                 445             


Ser Val Gly Asn Met Phe Tyr Val Phe Ser Asp Asp Gly Ile Ile Val 
    450                 455                 460                 


Ile His Pro Val Asp Cys Glu Ile Gln Arg His Leu Lys Pro Thr Glu 
465                 470                 475                 480 


Lys Ile Phe Met Ser Tyr Glu Glu Ile Cys Pro Gln Arg Glu Lys Asn 
                485                 490                 495     


Ala Thr Gln Pro Cys Gln Trp Val Ser Ala Val Asn Val Arg Asn Arg 
            500                 505                 510         


Tyr Ile Tyr Val Ala Gln Pro Ala Leu Ser Arg Val Leu Val Val Asp 
        515                 520                 525             


Ile Gln Ala Gln Lys Val Leu Gln Ser Ile Gly Val Asp Pro Leu Pro 
    530                 535                 540                 


Ala Lys Leu Ser Tyr Asp Lys Ser His Asp Gln Val Trp Val Leu Ser 
545                 550                 555                 560 


Trp Gly Asp Val His Lys Ser Arg Pro Ser Leu Gln Val Ile Thr Glu 
                565                 570                 575     


Ala Ser Thr Gly Gln Ser Gln His Leu Ile Arg Thr Pro Phe Ala Gly 
            580                 585                 590         


Val Asp Asp Phe Phe Ile Pro Pro Thr Asn Leu Ile Ile Asn His Ile 
        595                 600                 605             


Arg Phe Gly Phe Ile Phe Asn Lys Ser Asp Pro Ala Val His Lys Val 
    610                 615                 620                 


Asp Leu Glu Thr Met Met Pro Leu Lys Thr Ile Gly Leu His His His 
625                 630                 635                 640 


Gly Cys Val Pro Gln Ala Met Ala His Thr His Leu Gly Gly Tyr Phe 
                645                 650                 655     


Phe Ile Gln Cys Arg Gln Asp Ser Pro Ala Ser Ala Ala Arg Gln Leu 
            660                 665                 670         


Leu Val Asp Ser Val Thr Asp Ser Val Leu Gly Pro Asn Gly Asp Val 
        675                 680                 685             


Thr Gly Thr Pro His Thr Ser Pro Asp Gly Arg Phe Ile Val Ser Ala 
    690                 695                 700                 


Ala Ala Asp Ser Pro Trp Leu His Val Gln Glu Ile Thr Val Arg Gly 
705                 710                 715                 720 


Glu Ile Gln Thr Leu Tyr Asp Leu Gln Ile Asn Ser Gly Ile Ser Asp 
                725                 730                 735     


Leu Ala Phe Gln Arg Ser Phe Thr Glu Ser Asn Gln Tyr Asn Ile Tyr 
            740                 745                 750         


Ala Ala Leu His Thr Glu Pro Asp Leu Leu Phe Leu Glu Leu Ser Thr 
        755                 760                 765             


Gly Lys Val Gly Met Leu Lys Asn Leu Lys Glu Pro Pro Ala Gly Pro 
    770                 775                 780                 


Ala Gln Pro Trp Gly Gly Thr His Arg Ile Met Arg Asp Ser Gly Leu 
785                 790                 795                 800 


Phe Gly Gln Tyr Leu Leu Thr Pro Ala Arg Glu Ser Leu Phe Leu Ile 
                805                 810                 815     


Asn Gly Arg Gln Asn Thr Leu Arg Cys Glu Val Ser Gly Ile Lys Gly 
            820                 825                 830         


Gly Thr Thr Val Val Trp Val Gly Glu Val 
        835                 840         

<210>  2134
<211>  2699
<212>  DNA
<213>  Homo sapiens

<400>  2134
caacagactc atcaaaatga aaccaggagg cttttggctg catctcacac tgctcggagc     60

ctccctgccg gctgcgctgg gatggatgga cccaggaacc agcagaggcc cggatgtggg    120

tgtgggggag tcacaggcag agggctcagc ctcgcccccg aggacagggt cagtgtgacc    180

acagtgaccg tggggctgag cacagtgctg acctgcgccg tccatggaga cctgaggcca    240

ccaatcatct ggaagcgcaa cgggctcacc ctgaacttcc tggacttgga agacatcaat    300

gactttggag aggatgattc cctgtacatc accaaggtga ccaccatcca catgggcaat    360

tacacctgcc atgcttccgg ccacgagcag ctgttccaga cccacgtcct gcaggtgaat    420

gtgccgccag tcatccgtgt ctatccagag agccaggcac aggagcctgg agtggcagcc    480

agcctaagat gccatgctga gggcattccc atgcccagaa tcacttggct gaaaaacggc    540

gtggatgtct caactcagat gtccaaacag ctctcccttt tagccaatgg gagcgaactc    600

cacatcagca gtgttcggta tgaagacaca ggggcataca cctgcattgc caaaaatgaa    660

gtgggtgtgg atgaagatat ctcctcgctc ttcattgaag actcagctag aaagaccctt    720

gcaaacatcc tgtggcgaga ggaaggcctc agcgtgggaa acatgttcta tgtcttctcc    780

gacgacggta tcatcgtcat ccatcctgtg gactgtgaga tccagaggca cctcaaaccc    840

acggaaaaga ttttcatgag ctatgaagaa atctgtcctc aaagagaaaa aaatgcaacc    900

cagccctgcc agtgggtatc tgcagtcaat gtccggaacc ggtacatcta tgtggcccag    960

ccagcactga gcagagtcct tgtggtcgac atccaagccc agaaagtcct acagtccata   1020

ggtgtggacc ctctgccggc taagctgtcc tatgacaagt cacatgacca agtgtgggtc   1080

ctgagctggg gggacgtgca caagtcccga ccaagtctcc aggtgatcac agaagccagc   1140

accggccaga gccagcacct catccgcaca ccctttgcag gagtggatga tttcttcatt   1200

cccccaacaa acctcatcat caaccacatc aggtttggct tcatcttcaa caagtctgat   1260

cctgcagtcc acaaggtgga cctggaaaca atgatgcccc tcaagaccat cggcctgcac   1320

caccatggct gcgtgcccca ggccatggca cacacccacc tgggcggcta cttcttcatc   1380

cagtgccgac aggacagccc cgcctctgct gcccgacagc tgctcgttga cagtgtcaca   1440

gactctgtgc ttggccccaa tggtgatgta acaggcaccc cacacacatc ccccgacggg   1500

cgcttcatag tcagtgctgc agctgacagc ccctggctgc acgtgcagga gatcacagtg   1560

cggggcgaga tccagaccct gtatgacctg caaataaact cgggcatctc agacttggcc   1620

ttccagcgct ccttcactga aagcaatcaa tacaacatct acgcggctct gcacacggag   1680

ccggacctgc tgttcctgga gctgtccacg gggaaggtgg gcatgctgaa gaacttaaag   1740

gagccacccg cagggccagc tcagccctgg gggggtaccc acagaatcat gagggacagt   1800

gggctgtttg gacagtacct cctcacacca gcccgagagt cactgttcct catcaatggg   1860

agacaaaaca cgctgcggtg tgaggtgtca ggtataaagg gggggaccac agtggtgtgg   1920

gtgggtgagg tatgaagggc ccagagcaga gccctgggcc aaggaacacc ccctagtcct   1980

gacactgcag cctcaagcag gtacgctgta catttttaca gacaaaagca aaaacctgta   2040

ctcgctttgt ggttcaacac tggtctcctt gcaagtttcc tagtataagg tatgcgctgc   2100

taccaagatt ggggtttttt cgttaggaag tatgatttat gccttgagct acgatgagaa   2160

catatgctgc tgtgtaaagg gatcatttct gtgccaagct gcacaccgag tgacctgggg   2220

acatcatgga accaagggat cctgctctcc aagcagacac ctctgtcagt tgccttcaca   2280

tagtcattgt cccttactgc cagacccagc cagactttgc cctgacggag tggcccggaa   2340

gcagaggctg accaggagca ggggcctccc tcccgaactg aaagcccatc cgtcctcgcg   2400

tgggaccgca tcttctccct cgcagctgct tcttgctttt ctttccattt gacttgctgt   2460

aagcctgagg gagagccaac aagacttact gcatcttggg ggatggggaa atcactcact   2520

ttattttgga aatttttgat taaaaaaaaa ttttataatc tcaaatgcta gtaagcagaa   2580

agatgctctc cgaggtccaa ctatatcctt ccctgcctta ggccgagtct cgggggtggt   2640

cacaacccca catcccacag ccagaaagaa caatggtcat ctgagaatac tggccctgt    2699


<210>  2135
<211>  617
<212>  PRT
<213>  Homo sapiens

<400>  2135


Met Asp Gly Pro Arg Asn Gln Gln Arg Pro Gly Cys Gly Cys Gly Gly 
1               5                   10                  15      


Val Thr Gly Arg Gly Leu Ser Leu Ala Pro Glu Asp Arg Val Ser Val 
            20                  25                  30          


Thr Thr Val Thr Val Gly Leu Ser Thr Val Leu Thr Cys Ala Val His 
        35                  40                  45              


Gly Asp Leu Arg Pro Pro Ile Ile Trp Lys Arg Asn Gly Leu Thr Leu 
    50                  55                  60                  


Asn Phe Leu Asp Leu Glu Asp Ile Asn Asp Phe Gly Glu Asp Asp Ser 
65                  70                  75                  80  


Leu Tyr Ile Thr Lys Val Thr Thr Ile His Met Gly Asn Tyr Thr Cys 
                85                  90                  95      


His Ala Ser Gly His Glu Gln Leu Phe Gln Thr His Val Leu Gln Val 
            100                 105                 110         


Asn Val Pro Pro Val Ile Arg Val Tyr Pro Glu Ser Gln Ala Gln Glu 
        115                 120                 125             


Pro Gly Val Ala Ala Ser Leu Arg Cys His Ala Glu Gly Ile Pro Met 
    130                 135                 140                 


Pro Arg Ile Thr Trp Leu Lys Asn Gly Val Asp Val Ser Thr Gln Met 
145                 150                 155                 160 


Ser Lys Gln Leu Ser Leu Leu Ala Asn Gly Ser Glu Leu His Ile Ser 
                165                 170                 175     


Ser Val Arg Tyr Glu Asp Thr Gly Ala Tyr Thr Cys Ile Ala Lys Asn 
            180                 185                 190         


Glu Val Gly Val Asp Glu Asp Ile Ser Ser Leu Phe Ile Glu Asp Ser 
        195                 200                 205             


Ala Arg Lys Thr Leu Ala Asn Ile Leu Trp Arg Glu Glu Gly Leu Ser 
    210                 215                 220                 


Val Gly Asn Met Phe Tyr Val Phe Ser Asp Asp Gly Ile Ile Val Ile 
225                 230                 235                 240 


His Pro Val Asp Cys Glu Ile Gln Arg His Leu Lys Pro Thr Glu Lys 
                245                 250                 255     


Ile Phe Met Ser Tyr Glu Glu Ile Cys Pro Gln Arg Glu Lys Asn Ala 
            260                 265                 270         


Thr Gln Pro Cys Gln Trp Val Ser Ala Val Asn Val Arg Asn Arg Tyr 
        275                 280                 285             


Ile Tyr Val Ala Gln Pro Ala Leu Ser Arg Val Leu Val Val Asp Ile 
    290                 295                 300                 


Gln Ala Gln Lys Val Leu Gln Ser Ile Gly Val Asp Pro Leu Pro Ala 
305                 310                 315                 320 


Lys Leu Ser Tyr Asp Lys Ser His Asp Gln Val Trp Val Leu Ser Trp 
                325                 330                 335     


Gly Asp Val His Lys Ser Arg Pro Ser Leu Gln Val Ile Thr Glu Ala 
            340                 345                 350         


Ser Thr Gly Gln Ser Gln His Leu Ile Arg Thr Pro Phe Ala Gly Val 
        355                 360                 365             


Asp Asp Phe Phe Ile Pro Pro Thr Asn Leu Ile Ile Asn His Ile Arg 
    370                 375                 380                 


Phe Gly Phe Ile Phe Asn Lys Ser Asp Pro Ala Val His Lys Val Asp 
385                 390                 395                 400 


Leu Glu Thr Met Met Pro Leu Lys Thr Ile Gly Leu His His His Gly 
                405                 410                 415     


Cys Val Pro Gln Ala Met Ala His Thr His Leu Gly Gly Tyr Phe Phe 
            420                 425                 430         


Ile Gln Cys Arg Gln Asp Ser Pro Ala Ser Ala Ala Arg Gln Leu Leu 
        435                 440                 445             


Val Asp Ser Val Thr Asp Ser Val Leu Gly Pro Asn Gly Asp Val Thr 
    450                 455                 460                 


Gly Thr Pro His Thr Ser Pro Asp Gly Arg Phe Ile Val Ser Ala Ala 
465                 470                 475                 480 


Ala Asp Ser Pro Trp Leu His Val Gln Glu Ile Thr Val Arg Gly Glu 
                485                 490                 495     


Ile Gln Thr Leu Tyr Asp Leu Gln Ile Asn Ser Gly Ile Ser Asp Leu 
            500                 505                 510         


Ala Phe Gln Arg Ser Phe Thr Glu Ser Asn Gln Tyr Asn Ile Tyr Ala 
        515                 520                 525             


Ala Leu His Thr Glu Pro Asp Leu Leu Phe Leu Glu Leu Ser Thr Gly 
    530                 535                 540                 


Lys Val Gly Met Leu Lys Asn Leu Lys Glu Pro Pro Ala Gly Pro Ala 
545                 550                 555                 560 


Gln Pro Trp Gly Gly Thr His Arg Ile Met Arg Asp Ser Gly Leu Phe 
                565                 570                 575     


Gly Gln Tyr Leu Leu Thr Pro Ala Arg Glu Ser Leu Phe Leu Ile Asn 
            580                 585                 590         


Gly Arg Gln Asn Thr Leu Arg Cys Glu Val Ser Gly Ile Lys Gly Gly 
        595                 600                 605             


Thr Thr Val Val Trp Val Gly Glu Val 
    610                 615         

<210>  2136
<211>  488
<212>  DNA
<213>  Homo sapiens

<400>  2136
cagaaaacaa agatctcctg ttggcactca ggcttcctcc tgctctaggt gacacgtgca     60

ccatggccgg ctacgcccgc ttgaagaatg tccttctggc actccagacc cgtctgcagc    120

cactccaaga aggagacagc agacaagacc ctgcctccca gaagcgcctc ctggtggaat    180

ctctgttcag ggacttagat gcagatggca atggccacct cagcagctcc gaactggctc    240

agcatgtgct gaagaagcag gacctggatg aagacttact tggttgctca ccaggtgacc    300

tcctccgatt tgacgattac aacagtgaca gctccctgac cctccgcgag ttctacatgg    360

ccttccagga aagctggtga atttgttctg caacaagcct gagctttaag aaaagactaa    420

acggagagtg gatggggcca gagagggctt gccctgttcc tttttaataa agatttttct    480

cgctcttt                                                             488


<210>  2137
<211>  105
<212>  PRT
<213>  Homo sapiens

<400>  2137


Met Ala Gly Tyr Ala Arg Leu Lys Asn Val Leu Leu Ala Leu Gln Thr 
1               5                   10                  15      


Arg Leu Gln Pro Leu Gln Glu Gly Asp Ser Arg Gln Asp Pro Ala Ser 
            20                  25                  30          


Gln Lys Arg Leu Leu Val Glu Ser Leu Phe Arg Asp Leu Asp Ala Asp 
        35                  40                  45              


Gly Asn Gly His Leu Ser Ser Ser Glu Leu Ala Gln His Val Leu Lys 
    50                  55                  60                  


Lys Gln Asp Leu Asp Glu Asp Leu Leu Gly Cys Ser Pro Gly Asp Leu 
65                  70                  75                  80  


Leu Arg Phe Asp Asp Tyr Asn Ser Asp Ser Ser Leu Thr Leu Arg Glu 
                85                  90                  95      


Phe Tyr Met Ala Phe Gln Glu Ser Trp 
            100                 105 

<210>  2138
<211>  510
<212>  DNA
<213>  Homo sapiens

<400>  2138
tgtcacacca gcagtagagt ctccatctta tgagtcagag ctgagtggaa gatgagagcc     60

ccagactgct cagttgcatt tgcctggaat ttagtctcca cagcctggag ctggcaggga    120

ttagttgtgc tggcatcctg acctcccagg gaaatattat ataccttgac tggaagctgg    180

ggaagaggga accctgtctc cttggcactt ccatccagaa tgaagcttcc ttcacattta    240

gctggcaaag agagagggag caagcagatc atggctcaac tcaattccac agagaagaga    300

tggtgaactc aggcttgtct ctggtaaaat cattgtgtgc cctgggccca gaacccctgt    360

gtggacccct ttcctccctt cagctccacc agtacaatgg acccttgtcc agaaagggac    420

ttctcgtgaa taaatttgcc tccataatga ccgaatagga gaaagttgca catctaacca    480

cctgtaatta tcaaataaaa tcctttgtgc                                     510


<210>  2139
<211>  52
<212>  PRT
<213>  Homo sapiens

<400>  2139


Met Val Asn Ser Gly Leu Ser Leu Val Lys Ser Leu Cys Ala Leu Gly 
1               5                   10                  15      


Pro Glu Pro Leu Cys Gly Pro Leu Ser Ser Leu Gln Leu His Gln Tyr 
            20                  25                  30          


Asn Gly Pro Leu Ser Arg Lys Gly Leu Leu Val Asn Lys Phe Ala Ser 
        35                  40                  45              


Ile Met Thr Glu 
    50          

<210>  2140
<211>  275
<212>  DNA
<213>  Homo sapiens

<400>  2140
agttgtagcc ctgcatgctt tctggggagc acactctagc caccgagatg aaggcacggg     60

gaggcccgac cgtaggtcga acacgtcagt cagtggctga tccttcccat ggtctctgga    120

tacaccagtg aaggcaggag gtgaagtctc ccagatcacc tgggaacagc catggacact    180

tgtctggggc tgcatgagac agtgtctgag actcaccttt gacacaaatg taactgaagg    240

ggagaagctg cccctgggca agccggtcag ctgaa                               275


<210>  2141
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  2141


Met Leu Ser Gly Glu His Thr Leu Ala Thr Glu Met Lys Ala Arg Gly 
1               5                   10                  15      


Gly Pro Thr Val Gly Arg Thr Arg Gln Ser Val Ala Asp Pro Ser His 
            20                  25                  30          


Gly Leu Trp Ile His Gln 
        35              

<210>  2142
<211>  1122
<212>  DNA
<213>  Homo sapiens

<400>  2142
atggccgcgg attcagagac cccctgtgcg cctggagagc acagctttgg ggaacctggc     60

ccggaaagga gcctggagga gagcagagcc cgagaaacca gccgaaggac gcggggcggg    120

gtcgccgccg ccgccacggg gtgctccctc cctcccgccc aagtccggcc acctggtctt    180

cccctcggcc ccggccgtct caggtacgcg ggcgcagctc ccagcgggcg cggggagggt    240

gccatgtcgc tggcgccgcc accagccggt cccgctgcac cccactgggg tcctggcgcc    300

cgcggccccg catcttgctg cagggcccgg cgcgggcgct tgcttgtcct tactgcccgc    360

gccgggaaag ccaagtttgc ccgcggggaa gggaccgctg ggccagggct cggcagggct    420

accccggcca aggccaggac tcgaggagag gctgggacgc cgaggctcgt ggccggggtc    480

tacggtgggg accggagtga cccggttggc acgcggggcg ccacgcagaa gcgctcgggc    540

cgagcccgca gctcgcgccc ggctccgaaa tcctgcaggc gccgttcttg ggttcaggac    600

cccgagcggc cccggcggag ccaggcgagc gcggcccctc ggcccgggcc cggtgccctt    660

ggctccgggt tggggcgccg ggcaggcatt ctcagcacct cctccccgcg gctttgcggg    720

gaaacttgcg tctcctcgct gcagcccaaa gggcccgctg cgcttcgcct ggccctggct    780

tccccggggt ccgccgcatc cgacaaagcg gcgccaaccc caggcctgcc acctgaggac    840

tttgtgcccg caactcttgc gggagcggaa agccgccgag gcagtggggt ttcttgtttt    900

ccagagcgcg gcgagcctcc gcgcggcgcg gcaagtgcac taggagtgcg cgggtcagcg    960

gggcgggccc ggcgaggtcg gtgtcgcggc tcgagagcgg gtgccggggc gctgtccagc   1020

agccctcgct cgcggccgcg ggccgccgac actgatgaat ggcgcggcca cagcccgccg   1080

ctcccctcta ggtgtcgctt ccgccgagct ttcctccagt ga                      1122


<210>  2143
<211>  373
<212>  PRT
<213>  Homo sapiens

<400>  2143


Met Ala Ala Asp Ser Glu Thr Pro Cys Ala Pro Gly Glu His Ser Phe 
1               5                   10                  15      


Gly Glu Pro Gly Pro Glu Arg Ser Leu Glu Glu Ser Arg Ala Arg Glu 
            20                  25                  30          


Thr Ser Arg Arg Thr Arg Gly Gly Val Ala Ala Ala Ala Thr Gly Cys 
        35                  40                  45              


Ser Leu Pro Pro Ala Gln Val Arg Pro Pro Gly Leu Pro Leu Gly Pro 
    50                  55                  60                  


Gly Arg Leu Arg Tyr Ala Gly Ala Ala Pro Ser Gly Arg Gly Glu Gly 
65                  70                  75                  80  


Ala Met Ser Leu Ala Pro Pro Pro Ala Gly Pro Ala Ala Pro His Trp 
                85                  90                  95      


Gly Pro Gly Ala Arg Gly Pro Ala Ser Cys Cys Arg Ala Arg Arg Gly 
            100                 105                 110         


Arg Leu Leu Val Leu Thr Ala Arg Ala Gly Lys Ala Lys Phe Ala Arg 
        115                 120                 125             


Gly Glu Gly Thr Ala Gly Pro Gly Leu Gly Arg Ala Thr Pro Ala Lys 
    130                 135                 140                 


Ala Arg Thr Arg Gly Glu Ala Gly Thr Pro Arg Leu Val Ala Gly Val 
145                 150                 155                 160 


Tyr Gly Gly Asp Arg Ser Asp Pro Val Gly Thr Arg Gly Ala Thr Gln 
                165                 170                 175     


Lys Arg Ser Gly Arg Ala Arg Ser Ser Arg Pro Ala Pro Lys Ser Cys 
            180                 185                 190         


Arg Arg Arg Ser Trp Val Gln Asp Pro Glu Arg Pro Arg Arg Ser Gln 
        195                 200                 205             


Ala Ser Ala Ala Pro Arg Pro Gly Pro Gly Ala Leu Gly Ser Gly Leu 
    210                 215                 220                 


Gly Arg Arg Ala Gly Ile Leu Ser Thr Ser Ser Pro Arg Leu Cys Gly 
225                 230                 235                 240 


Glu Thr Cys Val Ser Ser Leu Gln Pro Lys Gly Pro Ala Ala Leu Arg 
                245                 250                 255     


Leu Ala Leu Ala Ser Pro Gly Ser Ala Ala Ser Asp Lys Ala Ala Pro 
            260                 265                 270         


Thr Pro Gly Leu Pro Pro Glu Asp Phe Val Pro Ala Thr Leu Ala Gly 
        275                 280                 285             


Ala Glu Ser Arg Arg Gly Ser Gly Val Ser Cys Phe Pro Glu Arg Gly 
    290                 295                 300                 


Glu Pro Pro Arg Gly Ala Ala Ser Ala Leu Gly Val Arg Gly Ser Ala 
305                 310                 315                 320 


Gly Arg Ala Arg Arg Gly Arg Cys Arg Gly Ser Arg Ala Gly Ala Gly 
                325                 330                 335     


Ala Leu Ser Ser Ser Pro Arg Ser Arg Pro Arg Ala Ala Asp Thr Asp 
            340                 345                 350         


Glu Trp Arg Gly His Ser Pro Pro Leu Pro Ser Arg Cys Arg Phe Arg 
        355                 360                 365             


Arg Ala Phe Leu Gln 
    370             

<210>  2144
<211>  3858
<212>  DNA
<213>  Homo sapiens

<400>  2144
agctactgat cactaaaagt gaaggaggaa gctccatttt gtcaccgcct gagagaagac     60

agaaacggta aagagataaa tgattggaaa tattagataa aatggcatga ttttgaagta    120

agaggagagc ataagaaagg tgtagtcctt ttgcaatggt gttttctagg agagggggcc    180

tgggagcccg ggatctgctt ctttggcttc tgctcctcgc agcctgggag gtggggagcg    240

gccagctcca ctactcgatc ccggaggaag ccaaacacgg caccttcgtt ggccgcgttg    300

ctcaggacct gggactggag ctggcggagc tggtgcctcg cctgttccgg gtggcgtcca    360

aaacacacag ggaccttctg gaggtaaatc tgcagaatgg cattttgttt gtgaattctc    420

ggatcgatcg cgaggagctg tgccagtgga gcgcggagtg cagcatccac ctggagttga    480

tcgccgacag gccgctgcag gttttccatg tggaggtgaa ggtgaaagac attaacgata    540

atccacccgt cttcaggggc agagaacaaa taatatttat tcctgaatct agactcctga    600

attcgcgttt tccgatagaa ggagctgctg atgcagacat tggtgctaac gctcttctaa    660

cgtacacgct cagcccgagt gattatttct ctttggatgt agaggcaagt gatgaactga    720

gtaaatctct ttggcttgaa ttgagaaaat atttggatag agaagaaaca ccagaacttc    780

acttattact gactgccact gatgggggca aaccggagct gcaaggtaca gttgagctgc    840

tgatcaccgt cctcgacgtt aatgataacg ccccactgtt tgaccaggcc gtatacagag    900

tccacttgtt agagactaca gcaaatggaa cattagtgac cacattaaat gcctctgatg    960

ctgacgaagg tgtaaatggt gaagtcgtct tttcctttga cagtggtatt tctcgtgaca   1020

ttcaagaaaa attcaaagtt gattccagct caggagaaat taggttaatt gataaactgg   1080

attatgaaga aacaaaatcc tacgaaattc aagtaaaggc agttgataaa ggaagtcctc   1140

cgatgtcaaa tcactgtaag gttttggtga aagtgctgga tgtaaatgat aatgctccag   1200

aactggcggt cacttcattg tatttgccta tcagagagga cgctccactc agcaccgtca   1260

tcgccctcat caccgtgtct gaccgtgact caggtgccaa cgggcaggtg acttgctcct   1320

taatgcccca cgtccccttc aagctggtgt ccaccttcaa gaattactac tcgttggtgt   1380

tggacagcgc cctggatcgc gagagcctgt cggtctatga gctggtggtg accgcgcggg   1440

acgggggctc gccttcgctg tgggccacgg ccagggtgtc cgtggaggtg gccgacgtga   1500

atgacaacgc gcctgcgttc gcgcagcccg agtacacagt attcgtgaag gagaacaacc   1560

cgccgggctg ccacatcttc acggtgtctg cgcgggacgc ggacgcgcag gagaacgcgc   1620

tggtgtccta ttcgctggtg gaacggcggg tgggcgagcg cgcgctgtcg aactacgtgt   1680

cagtgcacgc ggagagcggc aaggtgtacg cactgcagcc cctggaccac gaggagctgg   1740

agctgctgca gttccagcca cgacagccca accctgactg gcgttactct gcctccctga   1800

gagcaggcat gcacagctct gtgcacctag aggaggctgg cattctacgg gctggtccag   1860

gagggcctga tcagcagtgg ccaacagtat ccagtgcaac accagaacca gaggcaggag   1920

aagtgtcccc tccagtcggt gcgggtgtca acagcaacag ctggaccttt aaatacggac   1980

caggcaaccc caaacaatcc ggtcccggtg agttgcccga caaattcatt atcccaggat   2040

ctcctgcaat catctccatc cggcaggagc ctactaacag ccaaattgac aaaagtgact   2100

tcataacctt cggcaaaaag gaggagacca agaaaaagaa gaaaaagaag aagggtaaca   2160

agacccagga gaaaaaagag aaagggaaca gcacgactga caacagtgac cagtgaggtc   2220

ctcaaatgga aacaagccac ttagccagtt tttgtaataa tggcaaatct ctcccatgta   2280

gcaattccct gctccttttt cctatctaca tgagccctct tagagacctc agaaatctgc   2340

agaaagttcc ctgtgtctgt ctagaacgca tttaacaggt tttgtcgtaa aagctttact   2400

aagtctggtg ttaactcttt ctctccactc tggcttgttt tcagaaccta aaaagcagac   2460

ccaagtttcc tttctcctcc gccgcaaagg agaggcttcc cagccccgcc agtgagaggt   2520

tggactctct gccctgtgct ccggggatcc tgtcttgatg acacttgcag ggcaggctga   2580

aaagttttga gattgagcag cttgggagtt tgtggccact gggtatgtgt ggctaccgcg   2640

ggtatgcgag tgccagatat tggctgagac gagccagctt agactaattg gtacaaggaa   2700

ggcaagaaaa caaagacaaa taaacagcgg aagttatcag tatggagggg aagtgtaaac   2760

ttaaagggac cagactttct aaatcttaca actcaagagg tggcagccac cctctaggag   2820

acaaaactac ccccactgac aaggctttag gagaccctaa agtctgttgg ctgtgacgtc   2880

attataccta aaatctgcat catacctgca agccaacagt tcagtgtttt aacagagaac   2940

caccctggga aacagaagca gatctgatgt gtttcctata catgtcctgt gctcacttta   3000

ttaaaaattc ttttgcacac aatgtttatg aaaaggccag atccttttcc aatacttatg   3060

caaaagcaaa agaaaacccc gacacctcac ctttcgctgt ttgttgtttc atagatttat   3120

ttaaaaaaag agaaagtcta tagctataaa tctttaaaga gaaatatgaa tacaattccc   3180

ctaaactctc ctcaaaagag aattcagtct acagccattt aaatgatcat tgctgctaca   3240

gaagtgcttt aagagaattg cctgaaacat ctgtattata tcggccacct gccaatcaca   3300

gctttactct ttcaggtcac tctggggctg cctcttgcat gtattactaa ataaaatgat   3360

ctctctttct ctctctctct ctcttttcta agaaacaatt atgtgcactt tgatacacaa   3420

ccttctctaa ccaactatat atcaagaccc aaaaattgaa gaaaaatatt gttttctcat   3480

acagtgagca gatttttcaa tctactaatt ctgtgacttg tcttggtgtg ctagcctaca   3540

ccttctcttt ggtttagttt tccttttcta taacactctg aattgctaat cttactaaca   3600

cctatgatgt tacctgaaat caatctccca tatgtatgct gtatgctatg ctaagactcc   3660

tgaaatatac ttactctgtg cttgtgtatg tgaatgttaa tgcaactatt acctagagtg   3720

aactttaagc tttattgttg aatgtaattc cattatattt ccttttgtac acctgtgaaa   3780

aagtggagta gtgttttttt aaccattgtt aatcagcttt tgtgtatgaa agacacagta   3840

aaatttcttt cttaaatc                                                 3858


<210>  2145
<211>  686
<212>  PRT
<213>  Homo sapiens

<400>  2145


Met Val Phe Ser Arg Arg Gly Gly Leu Gly Ala Arg Asp Leu Leu Leu 
1               5                   10                  15      


Trp Leu Leu Leu Leu Ala Ala Trp Glu Val Gly Ser Gly Gln Leu His 
            20                  25                  30          


Tyr Ser Ile Pro Glu Glu Ala Lys His Gly Thr Phe Val Gly Arg Val 
        35                  40                  45              


Ala Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Pro Arg Leu Phe 
    50                  55                  60                  


Arg Val Ala Ser Lys Thr His Arg Asp Leu Leu Glu Val Asn Leu Gln 
65                  70                  75                  80  


Asn Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Gln Trp Ser Ala Glu Cys Ser Ile His Leu Glu Leu Ile Ala Asp Arg 
            100                 105                 110         


Pro Leu Gln Val Phe His Val Glu Val Lys Val Lys Asp Ile Asn Asp 
        115                 120                 125             


Asn Pro Pro Val Phe Arg Gly Arg Glu Gln Ile Ile Phe Ile Pro Glu 
    130                 135                 140                 


Ser Arg Leu Leu Asn Ser Arg Phe Pro Ile Glu Gly Ala Ala Asp Ala 
145                 150                 155                 160 


Asp Ile Gly Ala Asn Ala Leu Leu Thr Tyr Thr Leu Ser Pro Ser Asp 
                165                 170                 175     


Tyr Phe Ser Leu Asp Val Glu Ala Ser Asp Glu Leu Ser Lys Ser Leu 
            180                 185                 190         


Trp Leu Glu Leu Arg Lys Tyr Leu Asp Arg Glu Glu Thr Pro Glu Leu 
        195                 200                 205             


His Leu Leu Leu Thr Ala Thr Asp Gly Gly Lys Pro Glu Leu Gln Gly 
    210                 215                 220                 


Thr Val Glu Leu Leu Ile Thr Val Leu Asp Val Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Leu Phe Asp Gln Ala Val Tyr Arg Val His Leu Leu Glu Thr Thr Ala 
                245                 250                 255     


Asn Gly Thr Leu Val Thr Thr Leu Asn Ala Ser Asp Ala Asp Glu Gly 
            260                 265                 270         


Val Asn Gly Glu Val Val Phe Ser Phe Asp Ser Gly Ile Ser Arg Asp 
        275                 280                 285             


Ile Gln Glu Lys Phe Lys Val Asp Ser Ser Ser Gly Glu Ile Arg Leu 
    290                 295                 300                 


Ile Asp Lys Leu Asp Tyr Glu Glu Thr Lys Ser Tyr Glu Ile Gln Val 
305                 310                 315                 320 


Lys Ala Val Asp Lys Gly Ser Pro Pro Met Ser Asn His Cys Lys Val 
                325                 330                 335     


Leu Val Lys Val Leu Asp Val Asn Asp Asn Ala Pro Glu Leu Ala Val 
            340                 345                 350         


Thr Ser Leu Tyr Leu Pro Ile Arg Glu Asp Ala Pro Leu Ser Thr Val 
        355                 360                 365             


Ile Ala Leu Ile Thr Val Ser Asp Arg Asp Ser Gly Ala Asn Gly Gln 
    370                 375                 380                 


Val Thr Cys Ser Leu Met Pro His Val Pro Phe Lys Leu Val Ser Thr 
385                 390                 395                 400 


Phe Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu 
                405                 410                 415     


Ser Leu Ser Val Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser 
            420                 425                 430         


Pro Ser Leu Trp Ala Thr Ala Arg Val Ser Val Glu Val Ala Asp Val 
        435                 440                 445             


Asn Asp Asn Ala Pro Ala Phe Ala Gln Pro Glu Tyr Thr Val Phe Val 
    450                 455                 460                 


Lys Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Arg 
465                 470                 475                 480 


Asp Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu 
                485                 490                 495     


Arg Arg Val Gly Glu Arg Ala Leu Ser Asn Tyr Val Ser Val His Ala 
            500                 505                 510         


Glu Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu 
        515                 520                 525             


Glu Leu Leu Gln Phe Gln Pro Arg Gln Pro Asn Pro Asp Trp Arg Tyr 
    530                 535                 540                 


Ser Ala Ser Leu Arg Ala Gly Met His Ser Ser Val His Leu Glu Glu 
545                 550                 555                 560 


Ala Gly Ile Leu Arg Ala Gly Pro Gly Gly Pro Asp Gln Gln Trp Pro 
                565                 570                 575     


Thr Val Ser Ser Ala Thr Pro Glu Pro Glu Ala Gly Glu Val Ser Pro 
            580                 585                 590         


Pro Val Gly Ala Gly Val Asn Ser Asn Ser Trp Thr Phe Lys Tyr Gly 
        595                 600                 605             


Pro Gly Asn Pro Lys Gln Ser Gly Pro Gly Glu Leu Pro Asp Lys Phe 
    610                 615                 620                 


Ile Ile Pro Gly Ser Pro Ala Ile Ile Ser Ile Arg Gln Glu Pro Thr 
625                 630                 635                 640 


Asn Ser Gln Ile Asp Lys Ser Asp Phe Ile Thr Phe Gly Lys Lys Glu 
                645                 650                 655     


Glu Thr Lys Lys Lys Lys Lys Lys Lys Lys Gly Asn Lys Thr Gln Glu 
            660                 665                 670         


Lys Lys Glu Lys Gly Asn Ser Thr Thr Asp Asn Ser Asp Gln 
        675                 680                 685     

<210>  2146
<211>  4626
<212>  DNA
<213>  Homo sapiens

<400>  2146
agctactgat cactaaaagt gaaggaggaa gctccatttt gtcaccgcct gagagaagac     60

agaaacggta aagagataaa tgattggaaa tattagataa aatggcatga ttttgaagta    120

agaggagagc ataagaaagg tgtagtcctt ttgcaatggt gttttctagg agagggggcc    180

tgggagcccg ggatctgctt ctttggcttc tgctcctcgc agcctgggag gtggggagcg    240

gccagctcca ctactcgatc ccggaggaag ccaaacacgg caccttcgtt ggccgcgttg    300

ctcaggacct gggactggag ctggcggagc tggtgcctcg cctgttccgg gtggcgtcca    360

aaacacacag ggaccttctg gaggtaaatc tgcagaatgg cattttgttt gtgaattctc    420

ggatcgatcg cgaggagctg tgccagtgga gcgcggagtg cagcatccac ctggagttga    480

tcgccgacag gccgctgcag gttttccatg tggaggtgaa ggtgaaagac attaacgata    540

atccacccgt cttcaggggc agagaacaaa taatatttat tcctgaatct agactcctga    600

attcgcgttt tccgatagaa ggagctgctg atgcagacat tggtgctaac gctcttctaa    660

cgtacacgct cagcccgagt gattatttct ctttggatgt agaggcaagt gatgaactga    720

gtaaatctct ttggcttgaa ttgagaaaat atttggatag agaagaaaca ccagaacttc    780

acttattact gactgccact gatgggggca aaccggagct gcaaggtaca gttgagctgc    840

tgatcaccgt cctcgacgtt aatgataacg ccccactgtt tgaccaggcc gtatacagag    900

tccacttgtt agagactaca gcaaatggaa cattagtgac cacattaaat gcctctgatg    960

ctgacgaagg tgtaaatggt gaagtcgtct tttcctttga cagtggtatt tctcgtgaca   1020

ttcaagaaaa attcaaagtt gattccagct caggagaaat taggttaatt gataaactgg   1080

attatgaaga aacaaaatcc tacgaaattc aagtaaaggc agttgataaa ggaagtcctc   1140

cgatgtcaaa tcactgtaag gttttggtga aagtgctgga tgtaaatgat aatgctccag   1200

aactggcggt cacttcattg tatttgccta tcagagagga cgctccactc agcaccgtca   1260

tcgccctcat caccgtgtct gaccgtgact caggtgccaa cgggcaggtg acttgctcct   1320

taatgcccca cgtccccttc aagctggtgt ccaccttcaa gaattactac tcgttggtgt   1380

tggacagcgc cctggatcgc gagagcctgt cggtctatga gctggtggtg accgcgcggg   1440

acgggggctc gccttcgctg tgggccacgg ccagggtgtc cgtggaggtg gccgacgtga   1500

atgacaacgc gcctgcgttc gcgcagcccg agtacacagt attcgtgaag gagaacaacc   1560

cgccgggctg ccacatcttc acggtgtctg cgcgggacgc ggacgcgcag gagaacgcgc   1620

tggtgtccta ttcgctggtg gaacggcggg tgggcgagcg cgcgctgtcg aactacgtgt   1680

cagtgcacgc ggagagcggc aaggtgtacg cactgcagcc cctggaccac gaggagctgg   1740

agctgctgca gttccagcca cgacagccca accctgactg gcgttactct gcctccctga   1800

gagcaggcat gcacagctct gtgcacctag aggaggctgg cattctacgg gctggtccag   1860

gagggcctga tcagcagtgg ccaacagtat ccagtgcaac accagaacca gaggcaggag   1920

aagtgtcccc tccagtcggt gcgggtgtca acagcaacag ctggaccttt aaatacggac   1980

caggcaaccc caaacaatcc ggtcccggtg agttgcccga caaattcatt atcccaggat   2040

ctcctgcaat catctccatc cggcaggagc ctactaacag ccaaattgac aaaagtgact   2100

tcataacctt cggcaaaaag gaggagacca agaaaaagaa gaaaaagaag aagggtaaca   2160

agacccagga gaaaaaagag aaagggaaca gcacgactga caacagtgac cagtgaggtc   2220

ctcaaatgga aacaagccac ttagccagtt tttgtaataa tggcaaatct ctcccatgta   2280

gcaattccct gctccttttt cctatctaca tgagccctct tagagacctc agaaatctgc   2340

agaaagttcc ctgtgtctgt ctagaacgca tttaacaggt tttgtcgtaa aagctttact   2400

aagtctggtg ttaactcttt ctctccactc tggcttgttt tcagaaccta aaaagcagac   2460

ccaagtttcc tttctcctcc gccgcaaagg agaggcttcc cagccccgcc agtgagaggt   2520

tggactctct gccctgtgct ccggggatcc tgtcttgatg acacttgcag ggcaggctga   2580

aaagttttga gattgagcag cttgggagtt tgtggccact gggtatgtgt ggctaccgcg   2640

ggtatgcgag tgccagatat tggctgagac gagccagctt agactaattg gtacaaggaa   2700

ggcaagaaaa caaagacaaa taaacagcgg aagttatcag tatggagggg aagtgtaaac   2760

ttaaagggac cagactttct aaatcttaca actcaagagg tggcagccac cctctaggag   2820

acaaaactac ccccactgac aaggctttag gagaccctaa agtctgttgg ctgtgacgtc   2880

attataccta aaatctgcat catacctgca agccaacagt tcagtgtttt aacagagaac   2940

caccctggga aacagaagca gatctgatgt gtttcctata catgtcctgt gctcacttta   3000

ttaaaaattc ttttgcacac aatgtttatg aaaaggccag atccttttcc aatacttatg   3060

caaaagcaaa agaaaacccc gacacctcac ctttcgctgt ttgttgtttc atagatttat   3120

ttaaaaaaag agaaagtcta tagctataaa tctttaaaga gaaatatgaa tacaattccc   3180

ctaaactctc ctcaaaagag aattcagtct acagccattt aaatgatcat tgctgctaca   3240

gaagtgcttt aagagaattg cctgaaacat ctgtattata tcggccacct gccaatcaca   3300

gctttactct ttcaggtcac tctggggctg cctcttgcat gtattactaa ataaaatgat   3360

ctctctttct ctctctctct ctcttttcta agaaacaatt atgtgcactt tgatacacaa   3420

ccttctctaa ccaactatat atcaagaccc aaaaattgaa gaaaaatatt gttttctcat   3480

acagtgagca gatttttcaa tctactaatt ctgtgacttg tcttggtgtg ctagcctaca   3540

ccttctcttt ggtttagttt tccttttcta taacactctg aattgctaat cttactaaca   3600

cctatgatgt tacctgaaat caatctccca tatgtatgct gtatgctatg ctaagactcc   3660

tgaaatatac ttactctgtg cttgtgtatg tgaatgttaa tgcaactatt acctagagtg   3720

aactttaagc tttattgttg aatgtaattc cattatattt ccttttgtac acctgtgaaa   3780

aagtggagta gtgttttttt aaccattgtt aatcagcttt tgtgtatgaa agacacagta   3840

aaatttcttt cttaaatcaa gatactggtg attcaaggaa ttttatttat ggtccagcca   3900

agagccatct cgtgccaaga cttctgctgg caagggaatg gataaagctg ttttgttcta   3960

gtaacaattt tggaatgaat actgacaata ttccatgagg gtgtgcaagc acaaatttta   4020

ccaatctgac ctctttgaag ttgcagaatg ctttgaaatt ctaatggtat ctgaaatatc   4080

agctcataga aagtaacaaa atttgctgtc accttaaata agacatttta attttgttat   4140

aatgtacaat ttagaagttt gattaattat attatctatt taggcattaa tataaaagag   4200

gtaggagtct gttatttaaa aaaagcatta aatttaaaaa aaaactgtct tgtctacttt   4260

tagcttcatt ctcccatatt ttgaagggtg tgtaacttca gctctgcagg attgcatggg   4320

gtaaaacttg ttaccaacac atgtgaacca ttgctacatt gtaggttgtg atcattttgc   4380

cccactgaag cccatgtatc tgaccttacg tgccttttga actaggagaa tcgggctaat   4440

ttattaatga tgataattat aatgtatctg tacagcactt tttacatttg cgaagtgctt   4500

tccaatccat gttagttact agttattaca gctgtaagga taaaacacgt catgtggatt   4560

cattttgaat tggtgctatt ggtatttcct ctgttattgc taataaatga aaatggtggt   4620

atgaaa                                                              4626


<210>  2147
<211>  686
<212>  PRT
<213>  Homo sapiens

<400>  2147


Met Val Phe Ser Arg Arg Gly Gly Leu Gly Ala Arg Asp Leu Leu Leu 
1               5                   10                  15      


Trp Leu Leu Leu Leu Ala Ala Trp Glu Val Gly Ser Gly Gln Leu His 
            20                  25                  30          


Tyr Ser Ile Pro Glu Glu Ala Lys His Gly Thr Phe Val Gly Arg Val 
        35                  40                  45              


Ala Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Pro Arg Leu Phe 
    50                  55                  60                  


Arg Val Ala Ser Lys Thr His Arg Asp Leu Leu Glu Val Asn Leu Gln 
65                  70                  75                  80  


Asn Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Gln Trp Ser Ala Glu Cys Ser Ile His Leu Glu Leu Ile Ala Asp Arg 
            100                 105                 110         


Pro Leu Gln Val Phe His Val Glu Val Lys Val Lys Asp Ile Asn Asp 
        115                 120                 125             


Asn Pro Pro Val Phe Arg Gly Arg Glu Gln Ile Ile Phe Ile Pro Glu 
    130                 135                 140                 


Ser Arg Leu Leu Asn Ser Arg Phe Pro Ile Glu Gly Ala Ala Asp Ala 
145                 150                 155                 160 


Asp Ile Gly Ala Asn Ala Leu Leu Thr Tyr Thr Leu Ser Pro Ser Asp 
                165                 170                 175     


Tyr Phe Ser Leu Asp Val Glu Ala Ser Asp Glu Leu Ser Lys Ser Leu 
            180                 185                 190         


Trp Leu Glu Leu Arg Lys Tyr Leu Asp Arg Glu Glu Thr Pro Glu Leu 
        195                 200                 205             


His Leu Leu Leu Thr Ala Thr Asp Gly Gly Lys Pro Glu Leu Gln Gly 
    210                 215                 220                 


Thr Val Glu Leu Leu Ile Thr Val Leu Asp Val Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Leu Phe Asp Gln Ala Val Tyr Arg Val His Leu Leu Glu Thr Thr Ala 
                245                 250                 255     


Asn Gly Thr Leu Val Thr Thr Leu Asn Ala Ser Asp Ala Asp Glu Gly 
            260                 265                 270         


Val Asn Gly Glu Val Val Phe Ser Phe Asp Ser Gly Ile Ser Arg Asp 
        275                 280                 285             


Ile Gln Glu Lys Phe Lys Val Asp Ser Ser Ser Gly Glu Ile Arg Leu 
    290                 295                 300                 


Ile Asp Lys Leu Asp Tyr Glu Glu Thr Lys Ser Tyr Glu Ile Gln Val 
305                 310                 315                 320 


Lys Ala Val Asp Lys Gly Ser Pro Pro Met Ser Asn His Cys Lys Val 
                325                 330                 335     


Leu Val Lys Val Leu Asp Val Asn Asp Asn Ala Pro Glu Leu Ala Val 
            340                 345                 350         


Thr Ser Leu Tyr Leu Pro Ile Arg Glu Asp Ala Pro Leu Ser Thr Val 
        355                 360                 365             


Ile Ala Leu Ile Thr Val Ser Asp Arg Asp Ser Gly Ala Asn Gly Gln 
    370                 375                 380                 


Val Thr Cys Ser Leu Met Pro His Val Pro Phe Lys Leu Val Ser Thr 
385                 390                 395                 400 


Phe Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu 
                405                 410                 415     


Ser Leu Ser Val Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser 
            420                 425                 430         


Pro Ser Leu Trp Ala Thr Ala Arg Val Ser Val Glu Val Ala Asp Val 
        435                 440                 445             


Asn Asp Asn Ala Pro Ala Phe Ala Gln Pro Glu Tyr Thr Val Phe Val 
    450                 455                 460                 


Lys Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Arg 
465                 470                 475                 480 


Asp Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu 
                485                 490                 495     


Arg Arg Val Gly Glu Arg Ala Leu Ser Asn Tyr Val Ser Val His Ala 
            500                 505                 510         


Glu Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu 
        515                 520                 525             


Glu Leu Leu Gln Phe Gln Pro Arg Gln Pro Asn Pro Asp Trp Arg Tyr 
    530                 535                 540                 


Ser Ala Ser Leu Arg Ala Gly Met His Ser Ser Val His Leu Glu Glu 
545                 550                 555                 560 


Ala Gly Ile Leu Arg Ala Gly Pro Gly Gly Pro Asp Gln Gln Trp Pro 
                565                 570                 575     


Thr Val Ser Ser Ala Thr Pro Glu Pro Glu Ala Gly Glu Val Ser Pro 
            580                 585                 590         


Pro Val Gly Ala Gly Val Asn Ser Asn Ser Trp Thr Phe Lys Tyr Gly 
        595                 600                 605             


Pro Gly Asn Pro Lys Gln Ser Gly Pro Gly Glu Leu Pro Asp Lys Phe 
    610                 615                 620                 


Ile Ile Pro Gly Ser Pro Ala Ile Ile Ser Ile Arg Gln Glu Pro Thr 
625                 630                 635                 640 


Asn Ser Gln Ile Asp Lys Ser Asp Phe Ile Thr Phe Gly Lys Lys Glu 
                645                 650                 655     


Glu Thr Lys Lys Lys Lys Lys Lys Lys Lys Gly Asn Lys Thr Gln Glu 
            660                 665                 670         


Lys Lys Glu Lys Gly Asn Ser Thr Thr Asp Asn Ser Asp Gln 
        675                 680                 685     

<210>  2148
<211>  5418
<212>  DNA
<213>  Homo sapiens

<400>  2148
agctactgat cactaaaagt gaaggaggaa gctccatttt gtcaccgcct gagagaagac     60

agaaacggta aagagataaa tgattggaaa tattagataa aatggcatga ttttgaagta    120

agaggagagc ataagaaagg tgtagtcctt ttgcaatggt gttttctagg agagggggcc    180

tgggagcccg ggatctgctt ctttggcttc tgctcctcgc agcctgggag gtggggagcg    240

gccagctcca ctactcgatc ccggaggaag ccaaacacgg caccttcgtt ggccgcgttg    300

ctcaggacct gggactggag ctggcggagc tggtgcctcg cctgttccgg gtggcgtcca    360

aaacacacag ggaccttctg gaggtaaatc tgcagaatgg cattttgttt gtgaattctc    420

ggatcgatcg cgaggagctg tgccagtgga gcgcggagtg cagcatccac ctggagttga    480

tcgccgacag gccgctgcag gttttccatg tggaggtgaa ggtgaaagac attaacgata    540

atccacccgt cttcaggggc agagaacaaa taatatttat tcctgaatct agactcctga    600

attcgcgttt tccgatagaa ggagctgctg atgcagacat tggtgctaac gctcttctaa    660

cgtacacgct cagcccgagt gattatttct ctttggatgt agaggcaagt gatgaactga    720

gtaaatctct ttggcttgaa ttgagaaaat atttggatag agaagaaaca ccagaacttc    780

acttattact gactgccact gatgggggca aaccggagct gcaaggtaca gttgagctgc    840

tgatcaccgt cctcgacgtt aatgataacg ccccactgtt tgaccaggcc gtatacagag    900

tccacttgtt agagactaca gcaaatggaa cattagtgac cacattaaat gcctctgatg    960

ctgacgaagg tgtaaatggt gaagtcgtct tttcctttga cagtggtatt tctcgtgaca   1020

ttcaagaaaa attcaaagtt gattccagct caggagaaat taggttaatt gataaactgg   1080

attatgaaga aacaaaatcc tacgaaattc aagtaaaggc agttgataaa ggaagtcctc   1140

cgatgtcaaa tcactgtaag gttttggtga aagtgctgga tgtaaatgat aatgctccag   1200

aactggcggt cacttcattg tatttgccta tcagagagga cgctccactc agcaccgtca   1260

tcgccctcat caccgtgtct gaccgtgact caggtgccaa cgggcaggtg acttgctcct   1320

taatgcccca cgtccccttc aagctggtgt ccaccttcaa gaattactac tcgttggtgt   1380

tggacagcgc cctggatcgc gagagcctgt cggtctatga gctggtggtg accgcgcggg   1440

acgggggctc gccttcgctg tgggccacgg ccagggtgtc cgtggaggtg gccgacgtga   1500

atgacaacgc gcctgcgttc gcgcagcccg agtacacagt attcgtgaag gagaacaacc   1560

cgccgggctg ccacatcttc acggtgtctg cgcgggacgc ggacgcgcag gagaacgcgc   1620

tggtgtccta ttcgctggtg gaacggcggg tgggcgagcg cgcgctgtcg aactacgtgt   1680

cagtgcacgc ggagagcggc aaggtgtacg cactgcagcc cctggaccac gaggagctgg   1740

agctgctgca gttccaggtg agcgcgcggg atgcgggcgt gccgcctctg ggcagcaacg   1800

tgacgctgca ggtgttcgtg ctggacgaga acgacaacgc gccggcgctg ctggcgcctc   1860

gagtgggtgg cactattggt gcagtcagtg agctggtgcc gcgattggtg ggtgcgggtc   1920

atgtggtggc gaaggtgcgc gcagtggacg ccgactcggg ctacaacgcg tggctgtcct   1980

atgaactgca gccggcagca ggcggcgcgc gcatcccgtt ccgcgtgggg ctgtacacgg   2040

gcgagatcag cacgactcgt gtcctggacg aggctgactt gtcgcgctac cgccttctgg   2100

tgctagtgaa ggatcacggt gagccggcgc tgacagccac ggccactgtg cttgtatctc   2160

tggtggagag cggccaggcg ccaaaggcgt cttcgcgggc gtcggtgggt gtcgcgggcc   2220

cagaggcggc gctggtggat gtcaacgtgt acctgatcat cgccatctgc gcggtgtcca   2280

gcctgctggt gctcacactg ctgctgtaca cggcgctgcg gtgctcagtg ccgcccactg   2340

agggtgcgta tgtgccgggc aagcccactc tggtgtgctc cagcgcgttg gggagctggt   2400

cgaactcaca gcagaggcgg cagagggtgt gctctagcga gggcccaccc aagaccgacc   2460

tcatggcctt cagcccaggc ctatctccaa gtcttaacac gtcagaaaga aatgaacaac   2520

cagaagcaaa tttggatctt tctggtaatc cacgacagcc caaccctgac tggcgttact   2580

ctgcctccct gagagcaggc atgcacagct ctgtgcacct agaggaggct ggcattctac   2640

gggctggtcc aggagggcct gatcagcagt ggccaacagt atccagtgca acaccagaac   2700

cagaggcagg agaagtgtcc cctccagtcg gtgcgggtgt caacagcaac agctggacct   2760

ttaaatacgg accaggcaac cccaaacaat ccggtcccgg tgagttgccc gacaaattca   2820

ttatcccagg atctcctgca atcatctcca tccggcagga gcctactaac agccaaattg   2880

acaaaagtga cttcataacc ttcggcaaaa aggaggagac caagaaaaag aagaaaaaga   2940

agaagggtaa caagacccag gagaaaaaag agaaagggaa cagcacgact gacaacagtg   3000

accagtgagg tcctcaaatg gaaacaagcc acttagccag tttttgtaat aatggcaaat   3060

ctctcccatg tagcaattcc ctgctccttt ttcctatcta catgagccct cttagagacc   3120

tcagaaatct gcagaaagtt ccctgtgtct gtctagaacg catttaacag gttttgtcgt   3180

aaaagcttta ctaagtctgg tgttaactct ttctctccac tctggcttgt tttcagaacc   3240

taaaaagcag acccaagttt cctttctcct ccgccgcaaa ggagaggctt cccagccccg   3300

ccagtgagag gttggactct ctgccctgtg ctccggggat cctgtcttga tgacacttgc   3360

agggcaggct gaaaagtttt gagattgagc agcttgggag tttgtggcca ctgggtatgt   3420

gtggctaccg cgggtatgcg agtgccagat attggctgag acgagccagc ttagactaat   3480

tggtacaagg aaggcaagaa aacaaagaca aataaacagc ggaagttatc agtatggagg   3540

ggaagtgtaa acttaaaggg accagacttt ctaaatctta caactcaaga ggtggcagcc   3600

accctctagg agacaaaact acccccactg acaaggcttt aggagaccct aaagtctgtt   3660

ggctgtgacg tcattatacc taaaatctgc atcatacctg caagccaaca gttcagtgtt   3720

ttaacagaga accaccctgg gaaacagaag cagatctgat gtgtttccta tacatgtcct   3780

gtgctcactt tattaaaaat tcttttgcac acaatgttta tgaaaaggcc agatcctttt   3840

ccaatactta tgcaaaagca aaagaaaacc ccgacacctc acctttcgct gtttgttgtt   3900

tcatagattt atttaaaaaa agagaaagtc tatagctata aatctttaaa gagaaatatg   3960

aatacaattc ccctaaactc tcctcaaaag agaattcagt ctacagccat ttaaatgatc   4020

attgctgcta cagaagtgct ttaagagaat tgcctgaaac atctgtatta tatcggccac   4080

ctgccaatca cagctttact ctttcaggtc actctggggc tgcctcttgc atgtattact   4140

aaataaaatg atctctcttt ctctctctct ctctcttttc taagaaacaa ttatgtgcac   4200

tttgatacac aaccttctct aaccaactat atatcaagac ccaaaaattg aagaaaaata   4260

ttgttttctc atacagtgag cagatttttc aatctactaa ttctgtgact tgtcttggtg   4320

tgctagccta caccttctct ttggtttagt tttccttttc tataacactc tgaattgcta   4380

atcttactaa cacctatgat gttacctgaa atcaatctcc catatgtatg ctgtatgcta   4440

tgctaagact cctgaaatat acttactctg tgcttgtgta tgtgaatgtt aatgcaacta   4500

ttacctagag tgaactttaa gctttattgt tgaatgtaat tccattatat ttccttttgt   4560

acacctgtga aaaagtggag tagtgttttt ttaaccattg ttaatcagct tttgtgtatg   4620

aaagacacag taaaatttct ttcttaaatc aagatactgg tgattcaagg aattttattt   4680

atggtccagc caagagccat ctcgtgccaa gacttctgct ggcaagggaa tggataaagc   4740

tgttttgttc tagtaacaat tttggaatga atactgacaa tattccatga gggtgtgcaa   4800

gcacaaattt taccaatctg acctctttga agttgcagaa tgctttgaaa ttctaatggt   4860

atctgaaata tcagctcata gaaagtaaca aaatttgctg tcaccttaaa taagacattt   4920

taattttgtt ataatgtaca atttagaagt ttgattaatt atattatcta tttaggcatt   4980

aatataaaag aggtaggagt ctgttattta aaaaaagcat taaatttaaa aaaaaactgt   5040

cttgtctact tttagcttca ttctcccata ttttgaaggg tgtgtaactt cagctctgca   5100

ggattgcatg gggtaaaact tgttaccaac acatgtgaac cattgctaca ttgtaggttg   5160

tgatcatttt gccccactga agcccatgta tctgacctta cgtgcctttt gaactaggag   5220

aatcgggcta atttattaat gatgataatt ataatgtatc tgtacagcac tttttacatt   5280

tgcgaagtgc tttccaatcc atgttagtta ctagttatta cagctgtaag gataaaacac   5340

gtcatgtgga ttcattttga attggtgcta ttggtatttc ctctgttatt gctaataaat   5400

gaaaatggtg gtatgaaa                                                 5418


<210>  2149
<211>  950
<212>  PRT
<213>  Homo sapiens

<400>  2149


Met Val Phe Ser Arg Arg Gly Gly Leu Gly Ala Arg Asp Leu Leu Leu 
1               5                   10                  15      


Trp Leu Leu Leu Leu Ala Ala Trp Glu Val Gly Ser Gly Gln Leu His 
            20                  25                  30          


Tyr Ser Ile Pro Glu Glu Ala Lys His Gly Thr Phe Val Gly Arg Val 
        35                  40                  45              


Ala Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Pro Arg Leu Phe 
    50                  55                  60                  


Arg Val Ala Ser Lys Thr His Arg Asp Leu Leu Glu Val Asn Leu Gln 
65                  70                  75                  80  


Asn Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Gln Trp Ser Ala Glu Cys Ser Ile His Leu Glu Leu Ile Ala Asp Arg 
            100                 105                 110         


Pro Leu Gln Val Phe His Val Glu Val Lys Val Lys Asp Ile Asn Asp 
        115                 120                 125             


Asn Pro Pro Val Phe Arg Gly Arg Glu Gln Ile Ile Phe Ile Pro Glu 
    130                 135                 140                 


Ser Arg Leu Leu Asn Ser Arg Phe Pro Ile Glu Gly Ala Ala Asp Ala 
145                 150                 155                 160 


Asp Ile Gly Ala Asn Ala Leu Leu Thr Tyr Thr Leu Ser Pro Ser Asp 
                165                 170                 175     


Tyr Phe Ser Leu Asp Val Glu Ala Ser Asp Glu Leu Ser Lys Ser Leu 
            180                 185                 190         


Trp Leu Glu Leu Arg Lys Tyr Leu Asp Arg Glu Glu Thr Pro Glu Leu 
        195                 200                 205             


His Leu Leu Leu Thr Ala Thr Asp Gly Gly Lys Pro Glu Leu Gln Gly 
    210                 215                 220                 


Thr Val Glu Leu Leu Ile Thr Val Leu Asp Val Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Leu Phe Asp Gln Ala Val Tyr Arg Val His Leu Leu Glu Thr Thr Ala 
                245                 250                 255     


Asn Gly Thr Leu Val Thr Thr Leu Asn Ala Ser Asp Ala Asp Glu Gly 
            260                 265                 270         


Val Asn Gly Glu Val Val Phe Ser Phe Asp Ser Gly Ile Ser Arg Asp 
        275                 280                 285             


Ile Gln Glu Lys Phe Lys Val Asp Ser Ser Ser Gly Glu Ile Arg Leu 
    290                 295                 300                 


Ile Asp Lys Leu Asp Tyr Glu Glu Thr Lys Ser Tyr Glu Ile Gln Val 
305                 310                 315                 320 


Lys Ala Val Asp Lys Gly Ser Pro Pro Met Ser Asn His Cys Lys Val 
                325                 330                 335     


Leu Val Lys Val Leu Asp Val Asn Asp Asn Ala Pro Glu Leu Ala Val 
            340                 345                 350         


Thr Ser Leu Tyr Leu Pro Ile Arg Glu Asp Ala Pro Leu Ser Thr Val 
        355                 360                 365             


Ile Ala Leu Ile Thr Val Ser Asp Arg Asp Ser Gly Ala Asn Gly Gln 
    370                 375                 380                 


Val Thr Cys Ser Leu Met Pro His Val Pro Phe Lys Leu Val Ser Thr 
385                 390                 395                 400 


Phe Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu 
                405                 410                 415     


Ser Leu Ser Val Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser 
            420                 425                 430         


Pro Ser Leu Trp Ala Thr Ala Arg Val Ser Val Glu Val Ala Asp Val 
        435                 440                 445             


Asn Asp Asn Ala Pro Ala Phe Ala Gln Pro Glu Tyr Thr Val Phe Val 
    450                 455                 460                 


Lys Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Arg 
465                 470                 475                 480 


Asp Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu 
                485                 490                 495     


Arg Arg Val Gly Glu Arg Ala Leu Ser Asn Tyr Val Ser Val His Ala 
            500                 505                 510         


Glu Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu 
        515                 520                 525             


Glu Leu Leu Gln Phe Gln Val Ser Ala Arg Asp Ala Gly Val Pro Pro 
    530                 535                 540                 


Leu Gly Ser Asn Val Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp 
545                 550                 555                 560 


Asn Ala Pro Ala Leu Leu Ala Pro Arg Val Gly Gly Thr Ile Gly Ala 
                565                 570                 575     


Val Ser Glu Leu Val Pro Arg Leu Val Gly Ala Gly His Val Val Ala 
            580                 585                 590         


Lys Val Arg Ala Val Asp Ala Asp Ser Gly Tyr Asn Ala Trp Leu Ser 
        595                 600                 605             


Tyr Glu Leu Gln Pro Ala Ala Gly Gly Ala Arg Ile Pro Phe Arg Val 
    610                 615                 620                 


Gly Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Val Leu Asp Glu Ala 
625                 630                 635                 640 


Asp Leu Ser Arg Tyr Arg Leu Leu Val Leu Val Lys Asp His Gly Glu 
                645                 650                 655     


Pro Ala Leu Thr Ala Thr Ala Thr Val Leu Val Ser Leu Val Glu Ser 
            660                 665                 670         


Gly Gln Ala Pro Lys Ala Ser Ser Arg Ala Ser Val Gly Val Ala Gly 
        675                 680                 685             


Pro Glu Ala Ala Leu Val Asp Val Asn Val Tyr Leu Ile Ile Ala Ile 
    690                 695                 700                 


Cys Ala Val Ser Ser Leu Leu Val Leu Thr Leu Leu Leu Tyr Thr Ala 
705                 710                 715                 720 


Leu Arg Cys Ser Val Pro Pro Thr Glu Gly Ala Tyr Val Pro Gly Lys 
                725                 730                 735     


Pro Thr Leu Val Cys Ser Ser Ala Leu Gly Ser Trp Ser Asn Ser Gln 
            740                 745                 750         


Gln Arg Arg Gln Arg Val Cys Ser Ser Glu Gly Pro Pro Lys Thr Asp 
        755                 760                 765             


Leu Met Ala Phe Ser Pro Gly Leu Ser Pro Ser Leu Asn Thr Ser Glu 
    770                 775                 780                 


Arg Asn Glu Gln Pro Glu Ala Asn Leu Asp Leu Ser Gly Asn Pro Arg 
785                 790                 795                 800 


Gln Pro Asn Pro Asp Trp Arg Tyr Ser Ala Ser Leu Arg Ala Gly Met 
                805                 810                 815     


His Ser Ser Val His Leu Glu Glu Ala Gly Ile Leu Arg Ala Gly Pro 
            820                 825                 830         


Gly Gly Pro Asp Gln Gln Trp Pro Thr Val Ser Ser Ala Thr Pro Glu 
        835                 840                 845             


Pro Glu Ala Gly Glu Val Ser Pro Pro Val Gly Ala Gly Val Asn Ser 
    850                 855                 860                 


Asn Ser Trp Thr Phe Lys Tyr Gly Pro Gly Asn Pro Lys Gln Ser Gly 
865                 870                 875                 880 


Pro Gly Glu Leu Pro Asp Lys Phe Ile Ile Pro Gly Ser Pro Ala Ile 
                885                 890                 895     


Ile Ser Ile Arg Gln Glu Pro Thr Asn Ser Gln Ile Asp Lys Ser Asp 
            900                 905                 910         


Phe Ile Thr Phe Gly Lys Lys Glu Glu Thr Lys Lys Lys Lys Lys Lys 
        915                 920                 925             


Lys Lys Gly Asn Lys Thr Gln Glu Lys Lys Glu Lys Gly Asn Ser Thr 
    930                 935                 940                 


Thr Asp Asn Ser Asp Gln 
945                 950 

<210>  2150
<211>  5370
<212>  DNA
<213>  Homo sapiens

<400>  2150
acttcagaga agcggaggaa taagagaagc agcaggactt taacagagac tagaatattt     60

aaatttttgc aaaacatgct cttctaattt gatcaaaaca ttgaggattg gtaatggcgt    120

cttctatcag aaggggccga ggggcctgga cacggctgct ctcgcttctg ctcctcgcag    180

cctgggaggt ggggagcggc cagctccgct actccgtccc cgaggaggcc aaacacggca    240

ccttcgtggg ccgcatcgcg caggacctgg ggctggagct ggaggagctg gtgccgcgcc    300

tgttccgggt ggcgtccaaa agacacgggg accttctgga ggtaaatctg cagaatggca    360

ttttgtttgt gaattctcgg atcgaccggg aggagctgtg cgggcggagc gcggaatgta    420

gcatccacgt ggaggtgatc gtggacaggc cgctgcaggt tttccatgtg gaagtggagg    480

tgaaggacat taacgacaac ccgccaatat ttccaatgac agtaaagact atccggtttc    540

ccgaatcaag gctgcttgat tctcggtttc ctctagaggg agcatctgat gcagatatag    600

gagtaaatgc tcttctctcc tacaagctca gctccagtga gtttttcttc ctagatatac    660

aggcaaatga tgaactaagc gaatctttgt ctctcgtgct ggggaaatcg ctggacagag    720

aggaaactgc tgaggttaat ttgttactgg tggctactga tgggggcaaa cctgagctca    780

cgggcaccgt tcaaatactt attaaggtat tagatgtaaa tgacaatgaa ccaacttttg    840

cccaatcagt ttacaaagta aaattgttag agaatacggc aaatgggacc ttagtggtta    900

agttaaacgc ttctgatgca gatgaaggac cgaacagcga gattgtgtat tcactcggta    960

gtgatgtgtc ctccactata cagactaagt ttaccataga tcccatctca ggggaaatca   1020

gaactaaggg aaaattagat tatgaagaag caaagtccta cgagattcag gtcactgcaa   1080

ctgacaaagg aaccccttca atgtcaggac attgtaaaat ttcattaaaa cttgtggaca   1140

tcaatgataa cacaccagaa gtctcaataa cgtctctctc acttcccatc tcagagaacg   1200

cttccctggg cactgtcatt gctctcatca cggtgtcgga tcgcgactct ggtacgaatg   1260

gacatgtcac ctgctccctg acgccccacg tccctttcaa gctggtgtcc accttcaaga   1320

attactactc gttggtgctg gacagcgccc tggaccgcga gagcgtgtca gcctatgagc   1380

tggtggtgac cgcacgggac gggggctcgc cttcactgtg ggccaccacc agcgtgtcca   1440

tcgaggtggc cgacgtgaac gacaacgcgc cggcgttcgc acagcctgag tacacagtat   1500

tcgtgaagga gaacaacccg ccgggctgcc acatcttcac ggtgtcagcg tgggatgcgg   1560

acgcgcagga gaacgcgctg gtgtcctact cgctggtgga gcggcgggtg ggcgagcgcg   1620

cgttgtcgag ctacgtttcg gtgcacgcgg agagcggcaa ggtgtacgcg ctgcagccgc   1680

tggaccacga ggaagtggag ctgctgcagt tccaggtgag cgcgcgggat gcgggcgtgc   1740

cgcctctggg cagcaacgtg acgctgcagg tgttcgtgct ggacgagaac gacaacgcgc   1800

cggcactgtt ggcgcctagg gctggcaccg ctgctggcgc agtgagtgag ctggtgccgt   1860

ggtcggtggg tgcagggcac gtggtggcga aggtgcgcgc agtggacgct gactcaggct   1920

acaacgcgtg gctttcgtac gagcttcagc tgggtactgg cagcgctcgc atcccgttcc   1980

gcgtggggct atacacgggt gagatcagca cgacacgtgc cctagacgag gctgactccc   2040

ctcgacaccg cctactcgtg ctggtgaagg accacggcga accagcgttg acagccacgg   2100

ccaccgtgtt agtgtcgttg gtggaaagtg gccaggcacc caaggcctcg tcgcgggcgt   2160

gggtgggcgc cgcgggctca gaggctacgc tggtggatgt caacgtgtac ctgatcatcg   2220

ccatctgcgc ggtatccagc ctgttggtgc tcacggtgct gctgtacact gcgctgcggt   2280

gctcggtgcc acccaccgag ggtgcgcgcg cgccaggaaa gcccacgctg gtgtgctcca   2340

gcgccgtggg gagctggtct tactcgcagc agaggcggca gagggtgtgc tctggggagg   2400

acccccccaa gacggacctc atggccttca gccctagctt atctcaaggt ccagactccg   2460

cagaagagaa acagctctca gaatcagaat acgtaggaaa gccacgacag cccaaccctg   2520

actggcgtta ctctgcctcc ctgagagcag gcatgcacag ctctgtgcac ctagaggagg   2580

ctggcattct acgggctggt ccaggagggc ctgatcagca gtggccaaca gtatccagtg   2640

caacaccaga accagaggca ggagaagtgt cccctccagt cggtgcgggt gtcaacagca   2700

acagctggac ctttaaatac ggaccaggca accccaaaca atccggtccc ggtgagttgc   2760

ccgacaaatt cattatccca ggatctcctg caatcatctc catccggcag gagcctacta   2820

acagccaaat tgacaaaagt gacttcataa ccttcggcaa aaaggaggag accaagaaaa   2880

agaagaaaaa gaagaagggt aacaagaccc aggagaaaaa agagaaaggg aacagcacga   2940

ctgacaacag tgaccagtga ggtcctcaaa tggaaacaag ccacttagcc agtttttgta   3000

ataatggcaa atctctccca tgtagcaatt ccctgctcct ttttcctatc tacatgagcc   3060

ctcttagaga cctcagaaat ctgcagaaag ttccctgtgt ctgtctagaa cgcatttaac   3120

aggttttgtc gtaaaagctt tactaagtct ggtgttaact ctttctctcc actctggctt   3180

gttttcagaa cctaaaaagc agacccaagt ttcctttctc ctccgccgca aaggagaggc   3240

ttcccagccc cgccagtgag aggttggact ctctgccctg tgctccgggg atcctgtctt   3300

gatgacactt gcagggcagg ctgaaaagtt ttgagattga gcagcttggg agtttgtggc   3360

cactgggtat gtgtggctac cgcgggtatg cgagtgccag atattggctg agacgagcca   3420

gcttagacta attggtacaa ggaaggcaag aaaacaaaga caaataaaca gcggaagtta   3480

tcagtatgga ggggaagtgt aaacttaaag ggaccagact ttctaaatct tacaactcaa   3540

gaggtggcag ccaccctcta ggagacaaaa ctacccccac tgacaaggct ttaggagacc   3600

ctaaagtctg ttggctgtga cgtcattata cctaaaatct gcatcatacc tgcaagccaa   3660

cagttcagtg ttttaacaga gaaccaccct gggaaacaga agcagatctg atgtgtttcc   3720

tatacatgtc ctgtgctcac tttattaaaa attcttttgc acacaatgtt tatgaaaagg   3780

ccagatcctt ttccaatact tatgcaaaag caaaagaaaa ccccgacacc tcacctttcg   3840

ctgtttgttg tttcatagat ttatttaaaa aaagagaaag tctatagcta taaatcttta   3900

aagagaaata tgaatacaat tcccctaaac tctcctcaaa agagaattca gtctacagcc   3960

atttaaatga tcattgctgc tacagaagtg ctttaagaga attgcctgaa acatctgtat   4020

tatatcggcc acctgccaat cacagcttta ctctttcagg tcactctggg gctgcctctt   4080

gcatgtatta ctaaataaaa tgatctctct ttctctctct ctctctcttt tctaagaaac   4140

aattatgtgc actttgatac acaaccttct ctaaccaact atatatcaag acccaaaaat   4200

tgaagaaaaa tattgttttc tcatacagtg agcagatttt tcaatctact aattctgtga   4260

cttgtcttgg tgtgctagcc tacaccttct ctttggttta gttttccttt tctataacac   4320

tctgaattgc taatcttact aacacctatg atgttacctg aaatcaatct cccatatgta   4380

tgctgtatgc tatgctaaga ctcctgaaat atacttactc tgtgcttgtg tatgtgaatg   4440

ttaatgcaac tattacctag agtgaacttt aagctttatt gttgaatgta attccattat   4500

atttcctttt gtacacctgt gaaaaagtgg agtagtgttt ttttaaccat tgttaatcag   4560

cttttgtgta tgaaagacac agtaaaattt ctttcttaaa tcaagatact ggtgattcaa   4620

ggaattttat ttatggtcca gccaagagcc atctcgtgcc aagacttctg ctggcaaggg   4680

aatggataaa gctgttttgt tctagtaaca attttggaat gaatactgac aatattccat   4740

gagggtgtgc aagcacaaat tttaccaatc tgacctcttt gaagttgcag aatgctttga   4800

aattctaatg gtatctgaaa tatcagctca tagaaagtaa caaaatttgc tgtcacctta   4860

aataagacat tttaattttg ttataatgta caatttagaa gtttgattaa ttatattatc   4920

tatttaggca ttaatataaa agaggtagga gtctgttatt taaaaaaagc attaaattta   4980

aaaaaaaact gtcttgtcta cttttagctt cattctccca tattttgaag ggtgtgtaac   5040

ttcagctctg caggattgca tggggtaaaa cttgttacca acacatgtga accattgcta   5100

cattgtaggt tgtgatcatt ttgccccact gaagcccatg tatctgacct tacgtgcctt   5160

ttgaactagg agaatcgggc taatttatta atgatgataa ttataatgta tctgtacagc   5220

actttttaca tttgcgaagt gctttccaat ccatgttagt tactagttat tacagctgta   5280

aggataaaac acgtcatgtg gattcatttt gaattggtgc tattggtatt tcctctgtta   5340

ttgctaataa atgaaaatgg tggtatgaaa                                    5370


<210>  2151
<211>  948
<212>  PRT
<213>  Homo sapiens

<400>  2151


Met Ala Ser Ser Ile Arg Arg Gly Arg Gly Ala Trp Thr Arg Leu Leu 
1               5                   10                  15      


Ser Leu Leu Leu Leu Ala Ala Trp Glu Val Gly Ser Gly Gln Leu Arg 
            20                  25                  30          


Tyr Ser Val Pro Glu Glu Ala Lys His Gly Thr Phe Val Gly Arg Ile 
        35                  40                  45              


Ala Gln Asp Leu Gly Leu Glu Leu Glu Glu Leu Val Pro Arg Leu Phe 
    50                  55                  60                  


Arg Val Ala Ser Lys Arg His Gly Asp Leu Leu Glu Val Asn Leu Gln 
65                  70                  75                  80  


Asn Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Gly Arg Ser Ala Glu Cys Ser Ile His Val Glu Val Ile Val Asp Arg 
            100                 105                 110         


Pro Leu Gln Val Phe His Val Glu Val Glu Val Lys Asp Ile Asn Asp 
        115                 120                 125             


Asn Pro Pro Ile Phe Pro Met Thr Val Lys Thr Ile Arg Phe Pro Glu 
    130                 135                 140                 


Ser Arg Leu Leu Asp Ser Arg Phe Pro Leu Glu Gly Ala Ser Asp Ala 
145                 150                 155                 160 


Asp Ile Gly Val Asn Ala Leu Leu Ser Tyr Lys Leu Ser Ser Ser Glu 
                165                 170                 175     


Phe Phe Phe Leu Asp Ile Gln Ala Asn Asp Glu Leu Ser Glu Ser Leu 
            180                 185                 190         


Ser Leu Val Leu Gly Lys Ser Leu Asp Arg Glu Glu Thr Ala Glu Val 
        195                 200                 205             


Asn Leu Leu Leu Val Ala Thr Asp Gly Gly Lys Pro Glu Leu Thr Gly 
    210                 215                 220                 


Thr Val Gln Ile Leu Ile Lys Val Leu Asp Val Asn Asp Asn Glu Pro 
225                 230                 235                 240 


Thr Phe Ala Gln Ser Val Tyr Lys Val Lys Leu Leu Glu Asn Thr Ala 
                245                 250                 255     


Asn Gly Thr Leu Val Val Lys Leu Asn Ala Ser Asp Ala Asp Glu Gly 
            260                 265                 270         


Pro Asn Ser Glu Ile Val Tyr Ser Leu Gly Ser Asp Val Ser Ser Thr 
        275                 280                 285             


Ile Gln Thr Lys Phe Thr Ile Asp Pro Ile Ser Gly Glu Ile Arg Thr 
    290                 295                 300                 


Lys Gly Lys Leu Asp Tyr Glu Glu Ala Lys Ser Tyr Glu Ile Gln Val 
305                 310                 315                 320 


Thr Ala Thr Asp Lys Gly Thr Pro Ser Met Ser Gly His Cys Lys Ile 
                325                 330                 335     


Ser Leu Lys Leu Val Asp Ile Asn Asp Asn Thr Pro Glu Val Ser Ile 
            340                 345                 350         


Thr Ser Leu Ser Leu Pro Ile Ser Glu Asn Ala Ser Leu Gly Thr Val 
        355                 360                 365             


Ile Ala Leu Ile Thr Val Ser Asp Arg Asp Ser Gly Thr Asn Gly His 
    370                 375                 380                 


Val Thr Cys Ser Leu Thr Pro His Val Pro Phe Lys Leu Val Ser Thr 
385                 390                 395                 400 


Phe Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu 
                405                 410                 415     


Ser Val Ser Ala Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser 
            420                 425                 430         


Pro Ser Leu Trp Ala Thr Thr Ser Val Ser Ile Glu Val Ala Asp Val 
        435                 440                 445             


Asn Asp Asn Ala Pro Ala Phe Ala Gln Pro Glu Tyr Thr Val Phe Val 
    450                 455                 460                 


Lys Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Trp 
465                 470                 475                 480 


Asp Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu 
                485                 490                 495     


Arg Arg Val Gly Glu Arg Ala Leu Ser Ser Tyr Val Ser Val His Ala 
            500                 505                 510         


Glu Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Val 
        515                 520                 525             


Glu Leu Leu Gln Phe Gln Val Ser Ala Arg Asp Ala Gly Val Pro Pro 
    530                 535                 540                 


Leu Gly Ser Asn Val Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp 
545                 550                 555                 560 


Asn Ala Pro Ala Leu Leu Ala Pro Arg Ala Gly Thr Ala Ala Gly Ala 
                565                 570                 575     


Val Ser Glu Leu Val Pro Trp Ser Val Gly Ala Gly His Val Val Ala 
            580                 585                 590         


Lys Val Arg Ala Val Asp Ala Asp Ser Gly Tyr Asn Ala Trp Leu Ser 
        595                 600                 605             


Tyr Glu Leu Gln Leu Gly Thr Gly Ser Ala Arg Ile Pro Phe Arg Val 
    610                 615                 620                 


Gly Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Ala Leu Asp Glu Ala 
625                 630                 635                 640 


Asp Ser Pro Arg His Arg Leu Leu Val Leu Val Lys Asp His Gly Glu 
                645                 650                 655     


Pro Ala Leu Thr Ala Thr Ala Thr Val Leu Val Ser Leu Val Glu Ser 
            660                 665                 670         


Gly Gln Ala Pro Lys Ala Ser Ser Arg Ala Trp Val Gly Ala Ala Gly 
        675                 680                 685             


Ser Glu Ala Thr Leu Val Asp Val Asn Val Tyr Leu Ile Ile Ala Ile 
    690                 695                 700                 


Cys Ala Val Ser Ser Leu Leu Val Leu Thr Val Leu Leu Tyr Thr Ala 
705                 710                 715                 720 


Leu Arg Cys Ser Val Pro Pro Thr Glu Gly Ala Arg Ala Pro Gly Lys 
                725                 730                 735     


Pro Thr Leu Val Cys Ser Ser Ala Val Gly Ser Trp Ser Tyr Ser Gln 
            740                 745                 750         


Gln Arg Arg Gln Arg Val Cys Ser Gly Glu Asp Pro Pro Lys Thr Asp 
        755                 760                 765             


Leu Met Ala Phe Ser Pro Ser Leu Ser Gln Gly Pro Asp Ser Ala Glu 
    770                 775                 780                 


Glu Lys Gln Leu Ser Glu Ser Glu Tyr Val Gly Lys Pro Arg Gln Pro 
785                 790                 795                 800 


Asn Pro Asp Trp Arg Tyr Ser Ala Ser Leu Arg Ala Gly Met His Ser 
                805                 810                 815     


Ser Val His Leu Glu Glu Ala Gly Ile Leu Arg Ala Gly Pro Gly Gly 
            820                 825                 830         


Pro Asp Gln Gln Trp Pro Thr Val Ser Ser Ala Thr Pro Glu Pro Glu 
        835                 840                 845             


Ala Gly Glu Val Ser Pro Pro Val Gly Ala Gly Val Asn Ser Asn Ser 
    850                 855                 860                 


Trp Thr Phe Lys Tyr Gly Pro Gly Asn Pro Lys Gln Ser Gly Pro Gly 
865                 870                 875                 880 


Glu Leu Pro Asp Lys Phe Ile Ile Pro Gly Ser Pro Ala Ile Ile Ser 
                885                 890                 895     


Ile Arg Gln Glu Pro Thr Asn Ser Gln Ile Asp Lys Ser Asp Phe Ile 
            900                 905                 910         


Thr Phe Gly Lys Lys Glu Glu Thr Lys Lys Lys Lys Lys Lys Lys Lys 
        915                 920                 925             


Gly Asn Lys Thr Gln Glu Lys Lys Glu Lys Gly Asn Ser Thr Thr Asp 
    930                 935                 940                 


Asn Ser Asp Gln 
945             

<210>  2152
<211>  5433
<212>  DNA
<213>  Homo sapiens

<400>  2152
ctttctccac aaaagaaata acagcgtgca ttacgtattc agatactgct ttgcttcatc     60

ctctctaaaa tttaacaccg aggagtttaa gaaatgaaga taaggaactc gaattatttt    120

taaactttgg atcaatgtaa aggcaatcta atatttggaa aatacttgca atgttgttct    180

cctggcgaga agatcctgga gcccagtgcc tgctgctttc tcttctgctc ctcgcagcct    240

cggaggtggg gagcggccag ctccactact ccgtctctga ggaggccaag catggcacct    300

tcgtgggccg catcgcgcag gacctggggc tggagctggc ggagctggtg ccgcgcctgt    360

tccgggtggc gtccaaaaga cacggggacc ttctggaggt aaatctgcag aatggcattt    420

tgtttgtgaa ttctcggata gaccgcgagg aactgtgcgg gcggagcgcg gagtgcagca    480

tccacctgga ggtgatcgtg gacaggccgc tgcaggtttt ccatgtggag gtggaagtga    540

aggacattaa tgacaacgcg ccagtttttc caatggctgt aaagaatctg tttatttccg    600

aatcccgaca gcctggctct cggttttcgc tagagggcgc atcagatgca gatatcggaa    660

caaattcgtt gttgacttac agtcttgatt ccactgaata ttttaccttg gacgttaaaa    720

gaaatgatga ggaaattaaa tcccttggac tcgtgttgaa aaaaaattta aatcgagagg    780

acactcctaa gcattattta ctaataacag caattgatgg tgggaaacca gagctcactg    840

gcacgactca actaaagatc actgttttag atgtaaacga caacgcccca gcgtttgaga    900

ggacgatcta taaagtcaga ttactcgaaa atgcaccaaa tggtacccta gtggtgaccg    960

ttaacgccac cgatttggat gaaggagtaa ataaggatat cgcgtattct ttcaatacgg   1020

acatgtcagc agatattctg tcaaaattcc atttagatcc agtcaatgga caaatcagtg   1080

taaagggtaa catagatttc gaggaaagta agtcatatga aatccaggta gaagccacgg   1140

ataaaggaaa tcccccaatg tcagatcact gcacagttct actcgaaatt gtggacatca   1200

atgataatgt acctgagtta gttattcaat cactatcttt acctgtatta gaagactctc   1260

cacttagcac agtcatcgct ctgatcagcg tgtccgaccg cgactcagga gtcaatggac   1320

aggtcacctg ctcgctgacg ccccacgtcc ccttcaagct ggtgtccacc ttcaagaatt   1380

actactcatt ggtgctggac agccctctgg accgcgagag cgtgtcggcc tatgagctgg   1440

tggtgactgc tcgggacggg ggctcgcctt cactgtgggc cacggccagc gtgtccgtgg   1500

aggtggccga cgtgaacgac aatgcgccgg cattctcgca gtccgagtac acggtgttcg   1560

tgaaggagaa caacccgccg ggctgccaca tcttcacggt gtctgcgcgg gacgcggacg   1620

cgcaggagaa cgccctggtg tcctactcgc tggtggaacg gcgggtgggg gagcgcgcgc   1680

tgtcgagcta cgtgtcggta cacgcggaga gcggcaaggt gtacgcgctg cagccgctgg   1740

accacgagga gctagagctg ctgcagttcc aggtgagtgc gcgcgatgcg ggcgtgccgc   1800

ctctgggcag caacgtgacg ctgcaggtgt tcgtgctgga cgagaacgac aacgcgccgg   1860

cactgctgat gcctcgggtg ggtggcatcg gtggcgcagt gagcgagctg gtgccgcggt   1920

cagtgggtgc gggccacgtg gtagcgaagg tgcgcgcagt ggatgcagac tcaggctaca   1980

acgcgtggct ttcgtatgag ctgcagcctg ggaccggcgg tgcgcgcatc ccgtttcgcg   2040

tggggctgta cacgggagag atcagcacga cccgtgccct ggacgaggtg gacgccccgc   2100

gccatcgcct actggtgctg gtgaaggacc acggtgaacc ctcattgacc gccacggcca   2160

ctgtgctggt gtcgctggtg gagagtggcc aggcacccaa ggcctcgtcc caggcgtccg   2220

ctggcgccac gggcccggaa gctgcactgg tggatgtcaa cgtgtacttg atcgtcgcca   2280

tctgcgcggt gtccagtctg ttggtgctca cactgctgct atatactgct ctgcggtgct   2340

ccgcgccgcc aaccgaaggc gactgtgggc cgggcaagcc cacgctggtg tgctccagcg   2400

cggtggggag ctggtcatac tcgcagcaga ggcagcagag ggtgtgctct ggagaggggt   2460

tgcccaagac cgacctcatg gcttttagcc ctagccttcc tccttgtcca attagccggg   2520

atagagagga gaaacaggat gtggacgttg atctctcagc caaaccacga cagcccaacc   2580

ctgactggcg ttactctgcc tccctgagag caggcatgca cagctctgtg cacctagagg   2640

aggctggcat tctacgggct ggtccaggag ggcctgatca gcagtggcca acagtatcca   2700

gtgcaacacc agaaccagag gcaggagaag tgtcccctcc agtcggtgcg ggtgtcaaca   2760

gcaacagctg gacctttaaa tacggaccag gcaaccccaa acaatccggt cccggtgagt   2820

tgcccgacaa attcattatc ccaggatctc ctgcaatcat ctccatccgg caggagccta   2880

ctaacagcca aattgacaaa agtgacttca taaccttcgg caaaaaggag gagaccaaga   2940

aaaagaagaa aaagaagaag ggtaacaaga cccaggagaa aaaagagaaa gggaacagca   3000

cgactgacaa cagtgaccag tgaggtcctc aaatggaaac aagccactta gccagttttt   3060

gtaataatgg caaatctctc ccatgtagca attccctgct cctttttcct atctacatga   3120

gccctcttag agacctcaga aatctgcaga aagttccctg tgtctgtcta gaacgcattt   3180

aacaggtttt gtcgtaaaag ctttactaag tctggtgtta actctttctc tccactctgg   3240

cttgttttca gaacctaaaa agcagaccca agtttccttt ctcctccgcc gcaaaggaga   3300

ggcttcccag ccccgccagt gagaggttgg actctctgcc ctgtgctccg gggatcctgt   3360

cttgatgaca cttgcagggc aggctgaaaa gttttgagat tgagcagctt gggagtttgt   3420

ggccactggg tatgtgtggc taccgcgggt atgcgagtgc cagatattgg ctgagacgag   3480

ccagcttaga ctaattggta caaggaaggc aagaaaacaa agacaaataa acagcggaag   3540

ttatcagtat ggaggggaag tgtaaactta aagggaccag actttctaaa tcttacaact   3600

caagaggtgg cagccaccct ctaggagaca aaactacccc cactgacaag gctttaggag   3660

accctaaagt ctgttggctg tgacgtcatt atacctaaaa tctgcatcat acctgcaagc   3720

caacagttca gtgttttaac agagaaccac cctgggaaac agaagcagat ctgatgtgtt   3780

tcctatacat gtcctgtgct cactttatta aaaattcttt tgcacacaat gtttatgaaa   3840

aggccagatc cttttccaat acttatgcaa aagcaaaaga aaaccccgac acctcacctt   3900

tcgctgtttg ttgtttcata gatttattta aaaaaagaga aagtctatag ctataaatct   3960

ttaaagagaa atatgaatac aattccccta aactctcctc aaaagagaat tcagtctaca   4020

gccatttaaa tgatcattgc tgctacagaa gtgctttaag agaattgcct gaaacatctg   4080

tattatatcg gccacctgcc aatcacagct ttactctttc aggtcactct ggggctgcct   4140

cttgcatgta ttactaaata aaatgatctc tctttctctc tctctctctc ttttctaaga   4200

aacaattatg tgcactttga tacacaacct tctctaacca actatatatc aagacccaaa   4260

aattgaagaa aaatattgtt ttctcataca gtgagcagat ttttcaatct actaattctg   4320

tgacttgtct tggtgtgcta gcctacacct tctctttggt ttagttttcc ttttctataa   4380

cactctgaat tgctaatctt actaacacct atgatgttac ctgaaatcaa tctcccatat   4440

gtatgctgta tgctatgcta agactcctga aatatactta ctctgtgctt gtgtatgtga   4500

atgttaatgc aactattacc tagagtgaac tttaagcttt attgttgaat gtaattccat   4560

tatatttcct tttgtacacc tgtgaaaaag tggagtagtg tttttttaac cattgttaat   4620

cagcttttgt gtatgaaaga cacagtaaaa tttctttctt aaatcaagat actggtgatt   4680

caaggaattt tatttatggt ccagccaaga gccatctcgt gccaagactt ctgctggcaa   4740

gggaatggat aaagctgttt tgttctagta acaattttgg aatgaatact gacaatattc   4800

catgagggtg tgcaagcaca aattttacca atctgacctc tttgaagttg cagaatgctt   4860

tgaaattcta atggtatctg aaatatcagc tcatagaaag taacaaaatt tgctgtcacc   4920

ttaaataaga cattttaatt ttgttataat gtacaattta gaagtttgat taattatatt   4980

atctatttag gcattaatat aaaagaggta ggagtctgtt atttaaaaaa agcattaaat   5040

ttaaaaaaaa actgtcttgt ctacttttag cttcattctc ccatattttg aagggtgtgt   5100

aacttcagct ctgcaggatt gcatggggta aaacttgtta ccaacacatg tgaaccattg   5160

ctacattgta ggttgtgatc attttgcccc actgaagccc atgtatctga ccttacgtgc   5220

cttttgaact aggagaatcg ggctaattta ttaatgatga taattataat gtatctgtac   5280

agcacttttt acatttgcga agtgctttcc aatccatgtt agttactagt tattacagct   5340

gtaaggataa aacacgtcat gtggattcat tttgaattgg tgctattggt atttcctctg   5400

ttattgctaa taaatgaaaa tggtggtatg aaa                                5433


<210>  2153
<211>  950
<212>  PRT
<213>  Homo sapiens

<400>  2153


Met Leu Phe Ser Trp Arg Glu Asp Pro Gly Ala Gln Cys Leu Leu Leu 
1               5                   10                  15      


Ser Leu Leu Leu Leu Ala Ala Ser Glu Val Gly Ser Gly Gln Leu His 
            20                  25                  30          


Tyr Ser Val Ser Glu Glu Ala Lys His Gly Thr Phe Val Gly Arg Ile 
        35                  40                  45              


Ala Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Pro Arg Leu Phe 
    50                  55                  60                  


Arg Val Ala Ser Lys Arg His Gly Asp Leu Leu Glu Val Asn Leu Gln 
65                  70                  75                  80  


Asn Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Gly Arg Ser Ala Glu Cys Ser Ile His Leu Glu Val Ile Val Asp Arg 
            100                 105                 110         


Pro Leu Gln Val Phe His Val Glu Val Glu Val Lys Asp Ile Asn Asp 
        115                 120                 125             


Asn Ala Pro Val Phe Pro Met Ala Val Lys Asn Leu Phe Ile Ser Glu 
    130                 135                 140                 


Ser Arg Gln Pro Gly Ser Arg Phe Ser Leu Glu Gly Ala Ser Asp Ala 
145                 150                 155                 160 


Asp Ile Gly Thr Asn Ser Leu Leu Thr Tyr Ser Leu Asp Ser Thr Glu 
                165                 170                 175     


Tyr Phe Thr Leu Asp Val Lys Arg Asn Asp Glu Glu Ile Lys Ser Leu 
            180                 185                 190         


Gly Leu Val Leu Lys Lys Asn Leu Asn Arg Glu Asp Thr Pro Lys His 
        195                 200                 205             


Tyr Leu Leu Ile Thr Ala Ile Asp Gly Gly Lys Pro Glu Leu Thr Gly 
    210                 215                 220                 


Thr Thr Gln Leu Lys Ile Thr Val Leu Asp Val Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Ala Phe Glu Arg Thr Ile Tyr Lys Val Arg Leu Leu Glu Asn Ala Pro 
                245                 250                 255     


Asn Gly Thr Leu Val Val Thr Val Asn Ala Thr Asp Leu Asp Glu Gly 
            260                 265                 270         


Val Asn Lys Asp Ile Ala Tyr Ser Phe Asn Thr Asp Met Ser Ala Asp 
        275                 280                 285             


Ile Leu Ser Lys Phe His Leu Asp Pro Val Asn Gly Gln Ile Ser Val 
    290                 295                 300                 


Lys Gly Asn Ile Asp Phe Glu Glu Ser Lys Ser Tyr Glu Ile Gln Val 
305                 310                 315                 320 


Glu Ala Thr Asp Lys Gly Asn Pro Pro Met Ser Asp His Cys Thr Val 
                325                 330                 335     


Leu Leu Glu Ile Val Asp Ile Asn Asp Asn Val Pro Glu Leu Val Ile 
            340                 345                 350         


Gln Ser Leu Ser Leu Pro Val Leu Glu Asp Ser Pro Leu Ser Thr Val 
        355                 360                 365             


Ile Ala Leu Ile Ser Val Ser Asp Arg Asp Ser Gly Val Asn Gly Gln 
    370                 375                 380                 


Val Thr Cys Ser Leu Thr Pro His Val Pro Phe Lys Leu Val Ser Thr 
385                 390                 395                 400 


Phe Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Pro Leu Asp Arg Glu 
                405                 410                 415     


Ser Val Ser Ala Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser 
            420                 425                 430         


Pro Ser Leu Trp Ala Thr Ala Ser Val Ser Val Glu Val Ala Asp Val 
        435                 440                 445             


Asn Asp Asn Ala Pro Ala Phe Ser Gln Ser Glu Tyr Thr Val Phe Val 
    450                 455                 460                 


Lys Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Arg 
465                 470                 475                 480 


Asp Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu 
                485                 490                 495     


Arg Arg Val Gly Glu Arg Ala Leu Ser Ser Tyr Val Ser Val His Ala 
            500                 505                 510         


Glu Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu 
        515                 520                 525             


Glu Leu Leu Gln Phe Gln Val Ser Ala Arg Asp Ala Gly Val Pro Pro 
    530                 535                 540                 


Leu Gly Ser Asn Val Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp 
545                 550                 555                 560 


Asn Ala Pro Ala Leu Leu Met Pro Arg Val Gly Gly Ile Gly Gly Ala 
                565                 570                 575     


Val Ser Glu Leu Val Pro Arg Ser Val Gly Ala Gly His Val Val Ala 
            580                 585                 590         


Lys Val Arg Ala Val Asp Ala Asp Ser Gly Tyr Asn Ala Trp Leu Ser 
        595                 600                 605             


Tyr Glu Leu Gln Pro Gly Thr Gly Gly Ala Arg Ile Pro Phe Arg Val 
    610                 615                 620                 


Gly Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Ala Leu Asp Glu Val 
625                 630                 635                 640 


Asp Ala Pro Arg His Arg Leu Leu Val Leu Val Lys Asp His Gly Glu 
                645                 650                 655     


Pro Ser Leu Thr Ala Thr Ala Thr Val Leu Val Ser Leu Val Glu Ser 
            660                 665                 670         


Gly Gln Ala Pro Lys Ala Ser Ser Gln Ala Ser Ala Gly Ala Thr Gly 
        675                 680                 685             


Pro Glu Ala Ala Leu Val Asp Val Asn Val Tyr Leu Ile Val Ala Ile 
    690                 695                 700                 


Cys Ala Val Ser Ser Leu Leu Val Leu Thr Leu Leu Leu Tyr Thr Ala 
705                 710                 715                 720 


Leu Arg Cys Ser Ala Pro Pro Thr Glu Gly Asp Cys Gly Pro Gly Lys 
                725                 730                 735     


Pro Thr Leu Val Cys Ser Ser Ala Val Gly Ser Trp Ser Tyr Ser Gln 
            740                 745                 750         


Gln Arg Gln Gln Arg Val Cys Ser Gly Glu Gly Leu Pro Lys Thr Asp 
        755                 760                 765             


Leu Met Ala Phe Ser Pro Ser Leu Pro Pro Cys Pro Ile Ser Arg Asp 
    770                 775                 780                 


Arg Glu Glu Lys Gln Asp Val Asp Val Asp Leu Ser Ala Lys Pro Arg 
785                 790                 795                 800 


Gln Pro Asn Pro Asp Trp Arg Tyr Ser Ala Ser Leu Arg Ala Gly Met 
                805                 810                 815     


His Ser Ser Val His Leu Glu Glu Ala Gly Ile Leu Arg Ala Gly Pro 
            820                 825                 830         


Gly Gly Pro Asp Gln Gln Trp Pro Thr Val Ser Ser Ala Thr Pro Glu 
        835                 840                 845             


Pro Glu Ala Gly Glu Val Ser Pro Pro Val Gly Ala Gly Val Asn Ser 
    850                 855                 860                 


Asn Ser Trp Thr Phe Lys Tyr Gly Pro Gly Asn Pro Lys Gln Ser Gly 
865                 870                 875                 880 


Pro Gly Glu Leu Pro Asp Lys Phe Ile Ile Pro Gly Ser Pro Ala Ile 
                885                 890                 895     


Ile Ser Ile Arg Gln Glu Pro Thr Asn Ser Gln Ile Asp Lys Ser Asp 
            900                 905                 910         


Phe Ile Thr Phe Gly Lys Lys Glu Glu Thr Lys Lys Lys Lys Lys Lys 
        915                 920                 925             


Lys Lys Gly Asn Lys Thr Gln Glu Lys Lys Glu Lys Gly Asn Ser Thr 
    930                 935                 940                 


Thr Asp Asn Ser Asp Gln 
945                 950 

<210>  2154
<211>  4231
<212>  DNA
<213>  Homo sapiens

<400>  2154
acaaaataca tgagagaagg aggaagaagg gaaaattcct tctattctta ctggaaggaa     60

ccatatacac tctttggagt ctgaaatatg gaggatgcag ctgcacttga ctgaccgatt    120

aaaagatttc ccttgacttt gagaaacgat atttaatcag aacaaaatac tgtgcactaa    180

agatggagtt ttcctgggga agcggccagg aatcccggcg tctgctgctc ttacttcttc    240

tcctcgcagc ctgggaggca gggaacggtc agctccacta ctcggtctcc gaggaggcca    300

aacacggcac cttcgtgggc cgcatcgcgc aggacctggg actggagctg gcggagctgg    360

tgccgcgcct gttccgggtg gcgtccaagg gccgcggagg ccttctggag gtaaatctgc    420

agaatggcat tttgtttgtg aattctcgga tcgaccggga ggagctgtgc cggcggagcg    480

cggagtgcag catccacctg gaggtgatcg tagacaggcc gctgcaggtt ttccatgtgg    540

acgtggaggt gagggacatt aacgataacc cgccggtgtt cccagcaaca caaaagaacc    600

tgtccatcgc ggaatccagg ccgcttgact ctcggtttcc actagagggc gcctcggatg    660

cagatatcgg ggagaacgcc ctgctcactt acagactgag cccaaatgaa tacttttctc    720

tggaaaaacc acctgatgac gagctggtaa aaggtcttgg gcttatatta cggaaatctt    780

tagacagaga agaagctccg gagatttttt tagtgctcac agccactgat ggaggcaaac    840

ccgagttgac tggcaccgtt cagttactca tcacagtact ggatgccaat gacaatgccc    900

cagcttttga cagaaccatt tataaggtga gattactaga aaatgttcct aatggaacat    960

tggtaattaa acttaacgcc tcagatttag acgaaggatt gaatggggac attgtttatt   1020

cattctcaaa tgatatttcg ccaaatgtga aatccaagtt tcacatagat ccaattactg   1080

gacaaattat tgtaaaggga tatattgact ttgaagaaag caaatcctat gaaattattg   1140

tagagggcat tgataaggga cagctcccac tttctggcca ttgtagagtt attgtggaag   1200

tagaagacaa caacgataat gtcccagatt tggaattcaa gtctttatca cttccaatta   1260

gagaggacgc tccactgggt acagtcatcg ccctgatcag cgtgtccgac aaagacatgg   1320

gtgtcaatgg gctggtcacc tgctccttga cgtcccacgt ccccttcaag ctggtgtcca   1380

ccttcaagaa ttactactcg ttggtgctgg acagtgccct ggaccgcgag agcgtgtcag   1440

cctatgagct ggtggtgacc gcgcgagacg ggggctcgcc ttcgctgtgg gccacggcca   1500

gtgtttctgt ggaggtggct gatgtgaacg acaacgctcc ggcgttcgcg cagcccgagt   1560

acacagtgtt cgtgaaggag aacaacccgc cgggctgcca catcttcact gtgtctgcgt   1620

gggacgcgga cgcgcaggag aacgcgctgg tgtcctactc gctggtagag cggcgggtag   1680

gggagcgcgc gctgtcgagc tacgtttcgg tgcatgcgga gagcggcaag gtgtacgcgc   1740

tgcagccgct ggaccacgag gagctagagc tgctgcagtt tcaggtgacc gctcgcgatg   1800

ccggcgtgcc acctctgggc agcaacgtga cgctgcaggt gttcgtgctg gacgaaaacg   1860

acaacgcgcc agcactgcta gcgcctcggg cgggtggcac tggtggcgca gtgagcgagc   1920

tggtgccatg gtcggtgggt gtgggccacg tggtggcaaa ggtgcgcgcg gtggatgctg   1980

actcgggcta caacgcgtgg ctttcgtacg agctgcagcc ggggactggt ggcgcgcgca   2040

tcccgttccg cgtggggctg tacactggcg agatcagcac aacgcgtgcc ctggacgaaa   2100

cggacgctcc gcgccaccgc ctactggtac tggtgaagga ccacggcgag cccgcgctga   2160

cggccacggc cactgtgctg gtgtcacttg tggagagtgg acaggcgcca aaggcctcct   2220

cacgggcgtt ggtgggcgct gtgggtcccg atgctgcgct ggtggatgtc aacgtatacc   2280

tgatcattgc catctgcgcg gtgtccagcc ttttggtgct cacgctgctg ctgtacaccg   2340

cgctgcggtg ctctgcgctg cccaccgagg gcgcgtgcgc tccgggcaag cccacgctgg   2400

tgtgctccag tgcggtgggg agctggtcat actcgcagca gaggaggccg agggtgtgct   2460

ctggtgaggg cccacccaag accgacctca tggccttcag ccccagttta cctgactcta   2520

gggacagaga agatcagctg cagacaactg aggaatcctt tgcaaagcca cgacagccca   2580

accctgactg gcgttactct gcctccctga gagcaggcat gcacagctct gtgcacctag   2640

aggaggctgg cattctacgg gctggtccag gagggcctga tcagcagtgg ccaacagtat   2700

ccagtgcaac accagaacca gaggcaggag aagtgtcccc tccagtcggt gcgggtgtca   2760

acagcaacag ctggaccttt aaatacggac caggcaaccc caaacaatcc ggtcccgaac   2820

ctaaaaagca gacccaagtt tcctttctcc tccgccgcaa aggagaggct tcccagcccc   2880

gccagtgaga ggttggactc tctgccctgt gctccgggga tcctgtcttg atgacacttg   2940

cagggcaggc tgaaaagttt tgagattgag cagcttggga gtttgtggcc actgggtatg   3000

tgtggctacc gcgggtatgc gagtgccaga tattggctga gacgagccag cttagactaa   3060

ttggtacaag gaaggcaaga aaacaaagac aaataaacag cggaagttat cagtatggag   3120

gggaagtgta aacttaaagg gaccagactt tctaaatctt acaactcaag aggtggcagc   3180

caccctctag gagacaaaac tacccccact gacaaggctt taggagaccc taaagtctgt   3240

tggctgtgac gtcattatac ctaaaatctg catcatacct gcaagccaac agttcagtgt   3300

tttaacagag aaccaccctg ggaaacagaa gcagatctga tgtgtttcct atacatgtcc   3360

tgtgctcact ttattaaaaa ttcttttgca cacaatgttt atgaaaaggc cagatccttt   3420

tccaatactt atgcaaaagc aaaagaaaac cccgacacct cacctttcgc tgtttgttgt   3480

ttcatagatt tatttaaaaa aagagaaagt ctatagctat aaatctttaa agagaaatat   3540

gaatacaatt cccctaaact ctcctcaaaa gagaattcag tctacagcca tttaaatgat   3600

cattgctgct acagaagtgc tttaagagaa ttgcctgaaa catctgtatt atatcggcca   3660

cctgccaatc acagctttac tctttcaggt cactctgggg ctgcctcttg catgtattac   3720

taaataaaat gatctctctt tctctctctc tctctctttt ctaagaaaca attatgtgca   3780

ctttgataca caaccttctc taaccaacta tatatcaaga cccaaaaatt gaagaaaaat   3840

attgttttct catacagtga gcagattttt caatctacta attctgtgac ttgtcttggt   3900

gtgctagcct acaccttctc tttggtttag ttttcctttt ctataacact ctgaattgct   3960

aatcttacta acacctatga tgttacctga aatcaatctc ccatatgtat gctgtatgct   4020

atgctaagac tcctgaaata tacttactct gtgcttgtgt atgtgaatgt taatgcaact   4080

attacctaga gtgaacttta agctttattg ttgaatgtaa ttccattata tttccttttg   4140

tacacctgtg aaaaagtgga gtagtgtttt tttaaccatt gttaatcagc ttttgtgtat   4200

gaaagacaca gtaaaatttc tttcttaaat c                                  4231


<210>  2155
<211>  901
<212>  PRT
<213>  Homo sapiens

<400>  2155


Met Glu Phe Ser Trp Gly Ser Gly Gln Glu Ser Arg Arg Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Ala Ala Trp Glu Ala Gly Asn Gly Gln Leu His 
            20                  25                  30          


Tyr Ser Val Ser Glu Glu Ala Lys His Gly Thr Phe Val Gly Arg Ile 
        35                  40                  45              


Ala Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Pro Arg Leu Phe 
    50                  55                  60                  


Arg Val Ala Ser Lys Gly Arg Gly Gly Leu Leu Glu Val Asn Leu Gln 
65                  70                  75                  80  


Asn Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Arg Arg Ser Ala Glu Cys Ser Ile His Leu Glu Val Ile Val Asp Arg 
            100                 105                 110         


Pro Leu Gln Val Phe His Val Asp Val Glu Val Arg Asp Ile Asn Asp 
        115                 120                 125             


Asn Pro Pro Val Phe Pro Ala Thr Gln Lys Asn Leu Ser Ile Ala Glu 
    130                 135                 140                 


Ser Arg Pro Leu Asp Ser Arg Phe Pro Leu Glu Gly Ala Ser Asp Ala 
145                 150                 155                 160 


Asp Ile Gly Glu Asn Ala Leu Leu Thr Tyr Arg Leu Ser Pro Asn Glu 
                165                 170                 175     


Tyr Phe Ser Leu Glu Lys Pro Pro Asp Asp Glu Leu Val Lys Gly Leu 
            180                 185                 190         


Gly Leu Ile Leu Arg Lys Ser Leu Asp Arg Glu Glu Ala Pro Glu Ile 
        195                 200                 205             


Phe Leu Val Leu Thr Ala Thr Asp Gly Gly Lys Pro Glu Leu Thr Gly 
    210                 215                 220                 


Thr Val Gln Leu Leu Ile Thr Val Leu Asp Ala Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Ala Phe Asp Arg Thr Ile Tyr Lys Val Arg Leu Leu Glu Asn Val Pro 
                245                 250                 255     


Asn Gly Thr Leu Val Ile Lys Leu Asn Ala Ser Asp Leu Asp Glu Gly 
            260                 265                 270         


Leu Asn Gly Asp Ile Val Tyr Ser Phe Ser Asn Asp Ile Ser Pro Asn 
        275                 280                 285             


Val Lys Ser Lys Phe His Ile Asp Pro Ile Thr Gly Gln Ile Ile Val 
    290                 295                 300                 


Lys Gly Tyr Ile Asp Phe Glu Glu Ser Lys Ser Tyr Glu Ile Ile Val 
305                 310                 315                 320 


Glu Gly Ile Asp Lys Gly Gln Leu Pro Leu Ser Gly His Cys Arg Val 
                325                 330                 335     


Ile Val Glu Val Glu Asp Asn Asn Asp Asn Val Pro Asp Leu Glu Phe 
            340                 345                 350         


Lys Ser Leu Ser Leu Pro Ile Arg Glu Asp Ala Pro Leu Gly Thr Val 
        355                 360                 365             


Ile Ala Leu Ile Ser Val Ser Asp Lys Asp Met Gly Val Asn Gly Leu 
    370                 375                 380                 


Val Thr Cys Ser Leu Thr Ser His Val Pro Phe Lys Leu Val Ser Thr 
385                 390                 395                 400 


Phe Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu 
                405                 410                 415     


Ser Val Ser Ala Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser 
            420                 425                 430         


Pro Ser Leu Trp Ala Thr Ala Ser Val Ser Val Glu Val Ala Asp Val 
        435                 440                 445             


Asn Asp Asn Ala Pro Ala Phe Ala Gln Pro Glu Tyr Thr Val Phe Val 
    450                 455                 460                 


Lys Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Trp 
465                 470                 475                 480 


Asp Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu 
                485                 490                 495     


Arg Arg Val Gly Glu Arg Ala Leu Ser Ser Tyr Val Ser Val His Ala 
            500                 505                 510         


Glu Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu 
        515                 520                 525             


Glu Leu Leu Gln Phe Gln Val Thr Ala Arg Asp Ala Gly Val Pro Pro 
    530                 535                 540                 


Leu Gly Ser Asn Val Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp 
545                 550                 555                 560 


Asn Ala Pro Ala Leu Leu Ala Pro Arg Ala Gly Gly Thr Gly Gly Ala 
                565                 570                 575     


Val Ser Glu Leu Val Pro Trp Ser Val Gly Val Gly His Val Val Ala 
            580                 585                 590         


Lys Val Arg Ala Val Asp Ala Asp Ser Gly Tyr Asn Ala Trp Leu Ser 
        595                 600                 605             


Tyr Glu Leu Gln Pro Gly Thr Gly Gly Ala Arg Ile Pro Phe Arg Val 
    610                 615                 620                 


Gly Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Ala Leu Asp Glu Thr 
625                 630                 635                 640 


Asp Ala Pro Arg His Arg Leu Leu Val Leu Val Lys Asp His Gly Glu 
                645                 650                 655     


Pro Ala Leu Thr Ala Thr Ala Thr Val Leu Val Ser Leu Val Glu Ser 
            660                 665                 670         


Gly Gln Ala Pro Lys Ala Ser Ser Arg Ala Leu Val Gly Ala Val Gly 
        675                 680                 685             


Pro Asp Ala Ala Leu Val Asp Val Asn Val Tyr Leu Ile Ile Ala Ile 
    690                 695                 700                 


Cys Ala Val Ser Ser Leu Leu Val Leu Thr Leu Leu Leu Tyr Thr Ala 
705                 710                 715                 720 


Leu Arg Cys Ser Ala Leu Pro Thr Glu Gly Ala Cys Ala Pro Gly Lys 
                725                 730                 735     


Pro Thr Leu Val Cys Ser Ser Ala Val Gly Ser Trp Ser Tyr Ser Gln 
            740                 745                 750         


Gln Arg Arg Pro Arg Val Cys Ser Gly Glu Gly Pro Pro Lys Thr Asp 
        755                 760                 765             


Leu Met Ala Phe Ser Pro Ser Leu Pro Asp Ser Arg Asp Arg Glu Asp 
    770                 775                 780                 


Gln Leu Gln Thr Thr Glu Glu Ser Phe Ala Lys Pro Arg Gln Pro Asn 
785                 790                 795                 800 


Pro Asp Trp Arg Tyr Ser Ala Ser Leu Arg Ala Gly Met His Ser Ser 
                805                 810                 815     


Val His Leu Glu Glu Ala Gly Ile Leu Arg Ala Gly Pro Gly Gly Pro 
            820                 825                 830         


Asp Gln Gln Trp Pro Thr Val Ser Ser Ala Thr Pro Glu Pro Glu Ala 
        835                 840                 845             


Gly Glu Val Ser Pro Pro Val Gly Ala Gly Val Asn Ser Asn Ser Trp 
    850                 855                 860                 


Thr Phe Lys Tyr Gly Pro Gly Asn Pro Lys Gln Ser Gly Pro Glu Pro 
865                 870                 875                 880 


Lys Lys Gln Thr Gln Val Ser Phe Leu Leu Arg Arg Lys Gly Glu Ala 
                885                 890                 895     


Ser Gln Pro Arg Gln 
            900     

<210>  2156
<211>  4999
<212>  DNA
<213>  Homo sapiens

<400>  2156
acaaaataca tgagagaagg aggaagaagg gaaaattcct tctattctta ctggaaggaa     60

ccatatacac tctttggagt ctgaaatatg gaggatgcag ctgcacttga ctgaccgatt    120

aaaagatttc ccttgacttt gagaaacgat atttaatcag aacaaaatac tgtgcactaa    180

agatggagtt ttcctgggga agcggccagg aatcccggcg tctgctgctc ttacttcttc    240

tcctcgcagc ctgggaggca gggaacggtc agctccacta ctcggtctcc gaggaggcca    300

aacacggcac cttcgtgggc cgcatcgcgc aggacctggg actggagctg gcggagctgg    360

tgccgcgcct gttccgggtg gcgtccaagg gccgcggagg ccttctggag gtaaatctgc    420

agaatggcat tttgtttgtg aattctcgga tcgaccggga ggagctgtgc cggcggagcg    480

cggagtgcag catccacctg gaggtgatcg tagacaggcc gctgcaggtt ttccatgtgg    540

acgtggaggt gagggacatt aacgataacc cgccggtgtt cccagcaaca caaaagaacc    600

tgtccatcgc ggaatccagg ccgcttgact ctcggtttcc actagagggc gcctcggatg    660

cagatatcgg ggagaacgcc ctgctcactt acagactgag cccaaatgaa tacttttctc    720

tggaaaaacc acctgatgac gagctggtaa aaggtcttgg gcttatatta cggaaatctt    780

tagacagaga agaagctccg gagatttttt tagtgctcac agccactgat ggaggcaaac    840

ccgagttgac tggcaccgtt cagttactca tcacagtact ggatgccaat gacaatgccc    900

cagcttttga cagaaccatt tataaggtga gattactaga aaatgttcct aatggaacat    960

tggtaattaa acttaacgcc tcagatttag acgaaggatt gaatggggac attgtttatt   1020

cattctcaaa tgatatttcg ccaaatgtga aatccaagtt tcacatagat ccaattactg   1080

gacaaattat tgtaaaggga tatattgact ttgaagaaag caaatcctat gaaattattg   1140

tagagggcat tgataaggga cagctcccac tttctggcca ttgtagagtt attgtggaag   1200

tagaagacaa caacgataat gtcccagatt tggaattcaa gtctttatca cttccaatta   1260

gagaggacgc tccactgggt acagtcatcg ccctgatcag cgtgtccgac aaagacatgg   1320

gtgtcaatgg gctggtcacc tgctccttga cgtcccacgt ccccttcaag ctggtgtcca   1380

ccttcaagaa ttactactcg ttggtgctgg acagtgccct ggaccgcgag agcgtgtcag   1440

cctatgagct ggtggtgacc gcgcgagacg ggggctcgcc ttcgctgtgg gccacggcca   1500

gtgtttctgt ggaggtggct gatgtgaacg acaacgctcc ggcgttcgcg cagcccgagt   1560

acacagtgtt cgtgaaggag aacaacccgc cgggctgcca catcttcact gtgtctgcgt   1620

gggacgcgga cgcgcaggag aacgcgctgg tgtcctactc gctggtagag cggcgggtag   1680

gggagcgcgc gctgtcgagc tacgtttcgg tgcatgcgga gagcggcaag gtgtacgcgc   1740

tgcagccgct ggaccacgag gagctagagc tgctgcagtt tcaggtgacc gctcgcgatg   1800

ccggcgtgcc acctctgggc agcaacgtga cgctgcaggt gttcgtgctg gacgaaaacg   1860

acaacgcgcc agcactgcta gcgcctcggg cgggtggcac tggtggcgca gtgagcgagc   1920

tggtgccatg gtcggtgggt gtgggccacg tggtggcaaa ggtgcgcgcg gtggatgctg   1980

actcgggcta caacgcgtgg ctttcgtacg agctgcagcc ggggactggt ggcgcgcgca   2040

tcccgttccg cgtggggctg tacactggcg agatcagcac aacgcgtgcc ctggacgaaa   2100

cggacgctcc gcgccaccgc ctactggtac tggtgaagga ccacggcgag cccgcgctga   2160

cggccacggc cactgtgctg gtgtcacttg tggagagtgg acaggcgcca aaggcctcct   2220

cacgggcgtt ggtgggcgct gtgggtcccg atgctgcgct ggtggatgtc aacgtatacc   2280

tgatcattgc catctgcgcg gtgtccagcc ttttggtgct cacgctgctg ctgtacaccg   2340

cgctgcggtg ctctgcgctg cccaccgagg gcgcgtgcgc tccgggcaag cccacgctgg   2400

tgtgctccag tgcggtgggg agctggtcat actcgcagca gaggaggccg agggtgtgct   2460

ctggtgaggg cccacccaag accgacctca tggccttcag ccccagttta cctgactcta   2520

gggacagaga agatcagctg cagacaactg aggaatcctt tgcaaagcca cgacagccca   2580

accctgactg gcgttactct gcctccctga gagcaggcat gcacagctct gtgcacctag   2640

aggaggctgg cattctacgg gctggtccag gagggcctga tcagcagtgg ccaacagtat   2700

ccagtgcaac accagaacca gaggcaggag aagtgtcccc tccagtcggt gcgggtgtca   2760

acagcaacag ctggaccttt aaatacggac caggcaaccc caaacaatcc ggtcccgaac   2820

ctaaaaagca gacccaagtt tcctttctcc tccgccgcaa aggagaggct tcccagcccc   2880

gccagtgaga ggttggactc tctgccctgt gctccgggga tcctgtcttg atgacacttg   2940

cagggcaggc tgaaaagttt tgagattgag cagcttggga gtttgtggcc actgggtatg   3000

tgtggctacc gcgggtatgc gagtgccaga tattggctga gacgagccag cttagactaa   3060

ttggtacaag gaaggcaaga aaacaaagac aaataaacag cggaagttat cagtatggag   3120

gggaagtgta aacttaaagg gaccagactt tctaaatctt acaactcaag aggtggcagc   3180

caccctctag gagacaaaac tacccccact gacaaggctt taggagaccc taaagtctgt   3240

tggctgtgac gtcattatac ctaaaatctg catcatacct gcaagccaac agttcagtgt   3300

tttaacagag aaccaccctg ggaaacagaa gcagatctga tgtgtttcct atacatgtcc   3360

tgtgctcact ttattaaaaa ttcttttgca cacaatgttt atgaaaaggc cagatccttt   3420

tccaatactt atgcaaaagc aaaagaaaac cccgacacct cacctttcgc tgtttgttgt   3480

ttcatagatt tatttaaaaa aagagaaagt ctatagctat aaatctttaa agagaaatat   3540

gaatacaatt cccctaaact ctcctcaaaa gagaattcag tctacagcca tttaaatgat   3600

cattgctgct acagaagtgc tttaagagaa ttgcctgaaa catctgtatt atatcggcca   3660

cctgccaatc acagctttac tctttcaggt cactctgggg ctgcctcttg catgtattac   3720

taaataaaat gatctctctt tctctctctc tctctctttt ctaagaaaca attatgtgca   3780

ctttgataca caaccttctc taaccaacta tatatcaaga cccaaaaatt gaagaaaaat   3840

attgttttct catacagtga gcagattttt caatctacta attctgtgac ttgtcttggt   3900

gtgctagcct acaccttctc tttggtttag ttttcctttt ctataacact ctgaattgct   3960

aatcttacta acacctatga tgttacctga aatcaatctc ccatatgtat gctgtatgct   4020

atgctaagac tcctgaaata tacttactct gtgcttgtgt atgtgaatgt taatgcaact   4080

attacctaga gtgaacttta agctttattg ttgaatgtaa ttccattata tttccttttg   4140

tacacctgtg aaaaagtgga gtagtgtttt tttaaccatt gttaatcagc ttttgtgtat   4200

gaaagacaca gtaaaatttc tttcttaaat caagatactg gtgattcaag gaattttatt   4260

tatggtccag ccaagagcca tctcgtgcca agacttctgc tggcaaggga atggataaag   4320

ctgttttgtt ctagtaacaa ttttggaatg aatactgaca atattccatg agggtgtgca   4380

agcacaaatt ttaccaatct gacctctttg aagttgcaga atgctttgaa attctaatgg   4440

tatctgaaat atcagctcat agaaagtaac aaaatttgct gtcaccttaa ataagacatt   4500

ttaattttgt tataatgtac aatttagaag tttgattaat tatattatct atttaggcat   4560

taatataaaa gaggtaggag tctgttattt aaaaaaagca ttaaatttaa aaaaaaactg   4620

tcttgtctac ttttagcttc attctcccat attttgaagg gtgtgtaact tcagctctgc   4680

aggattgcat ggggtaaaac ttgttaccaa cacatgtgaa ccattgctac attgtaggtt   4740

gtgatcattt tgccccactg aagcccatgt atctgacctt acgtgccttt tgaactagga   4800

gaatcgggct aatttattaa tgatgataat tataatgtat ctgtacagca ctttttacat   4860

ttgcgaagtg ctttccaatc catgttagtt actagttatt acagctgtaa ggataaaaca   4920

cgtcatgtgg attcattttg aattggtgct attggtattt cctctgttat tgctaataaa   4980

tgaaaatggt ggtatgaaa                                                4999


<210>  2157
<211>  901
<212>  PRT
<213>  Homo sapiens

<400>  2157


Met Glu Phe Ser Trp Gly Ser Gly Gln Glu Ser Arg Arg Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Ala Ala Trp Glu Ala Gly Asn Gly Gln Leu His 
            20                  25                  30          


Tyr Ser Val Ser Glu Glu Ala Lys His Gly Thr Phe Val Gly Arg Ile 
        35                  40                  45              


Ala Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Pro Arg Leu Phe 
    50                  55                  60                  


Arg Val Ala Ser Lys Gly Arg Gly Gly Leu Leu Glu Val Asn Leu Gln 
65                  70                  75                  80  


Asn Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Arg Arg Ser Ala Glu Cys Ser Ile His Leu Glu Val Ile Val Asp Arg 
            100                 105                 110         


Pro Leu Gln Val Phe His Val Asp Val Glu Val Arg Asp Ile Asn Asp 
        115                 120                 125             


Asn Pro Pro Val Phe Pro Ala Thr Gln Lys Asn Leu Ser Ile Ala Glu 
    130                 135                 140                 


Ser Arg Pro Leu Asp Ser Arg Phe Pro Leu Glu Gly Ala Ser Asp Ala 
145                 150                 155                 160 


Asp Ile Gly Glu Asn Ala Leu Leu Thr Tyr Arg Leu Ser Pro Asn Glu 
                165                 170                 175     


Tyr Phe Ser Leu Glu Lys Pro Pro Asp Asp Glu Leu Val Lys Gly Leu 
            180                 185                 190         


Gly Leu Ile Leu Arg Lys Ser Leu Asp Arg Glu Glu Ala Pro Glu Ile 
        195                 200                 205             


Phe Leu Val Leu Thr Ala Thr Asp Gly Gly Lys Pro Glu Leu Thr Gly 
    210                 215                 220                 


Thr Val Gln Leu Leu Ile Thr Val Leu Asp Ala Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Ala Phe Asp Arg Thr Ile Tyr Lys Val Arg Leu Leu Glu Asn Val Pro 
                245                 250                 255     


Asn Gly Thr Leu Val Ile Lys Leu Asn Ala Ser Asp Leu Asp Glu Gly 
            260                 265                 270         


Leu Asn Gly Asp Ile Val Tyr Ser Phe Ser Asn Asp Ile Ser Pro Asn 
        275                 280                 285             


Val Lys Ser Lys Phe His Ile Asp Pro Ile Thr Gly Gln Ile Ile Val 
    290                 295                 300                 


Lys Gly Tyr Ile Asp Phe Glu Glu Ser Lys Ser Tyr Glu Ile Ile Val 
305                 310                 315                 320 


Glu Gly Ile Asp Lys Gly Gln Leu Pro Leu Ser Gly His Cys Arg Val 
                325                 330                 335     


Ile Val Glu Val Glu Asp Asn Asn Asp Asn Val Pro Asp Leu Glu Phe 
            340                 345                 350         


Lys Ser Leu Ser Leu Pro Ile Arg Glu Asp Ala Pro Leu Gly Thr Val 
        355                 360                 365             


Ile Ala Leu Ile Ser Val Ser Asp Lys Asp Met Gly Val Asn Gly Leu 
    370                 375                 380                 


Val Thr Cys Ser Leu Thr Ser His Val Pro Phe Lys Leu Val Ser Thr 
385                 390                 395                 400 


Phe Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu 
                405                 410                 415     


Ser Val Ser Ala Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser 
            420                 425                 430         


Pro Ser Leu Trp Ala Thr Ala Ser Val Ser Val Glu Val Ala Asp Val 
        435                 440                 445             


Asn Asp Asn Ala Pro Ala Phe Ala Gln Pro Glu Tyr Thr Val Phe Val 
    450                 455                 460                 


Lys Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Trp 
465                 470                 475                 480 


Asp Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu 
                485                 490                 495     


Arg Arg Val Gly Glu Arg Ala Leu Ser Ser Tyr Val Ser Val His Ala 
            500                 505                 510         


Glu Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu 
        515                 520                 525             


Glu Leu Leu Gln Phe Gln Val Thr Ala Arg Asp Ala Gly Val Pro Pro 
    530                 535                 540                 


Leu Gly Ser Asn Val Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp 
545                 550                 555                 560 


Asn Ala Pro Ala Leu Leu Ala Pro Arg Ala Gly Gly Thr Gly Gly Ala 
                565                 570                 575     


Val Ser Glu Leu Val Pro Trp Ser Val Gly Val Gly His Val Val Ala 
            580                 585                 590         


Lys Val Arg Ala Val Asp Ala Asp Ser Gly Tyr Asn Ala Trp Leu Ser 
        595                 600                 605             


Tyr Glu Leu Gln Pro Gly Thr Gly Gly Ala Arg Ile Pro Phe Arg Val 
    610                 615                 620                 


Gly Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Ala Leu Asp Glu Thr 
625                 630                 635                 640 


Asp Ala Pro Arg His Arg Leu Leu Val Leu Val Lys Asp His Gly Glu 
                645                 650                 655     


Pro Ala Leu Thr Ala Thr Ala Thr Val Leu Val Ser Leu Val Glu Ser 
            660                 665                 670         


Gly Gln Ala Pro Lys Ala Ser Ser Arg Ala Leu Val Gly Ala Val Gly 
        675                 680                 685             


Pro Asp Ala Ala Leu Val Asp Val Asn Val Tyr Leu Ile Ile Ala Ile 
    690                 695                 700                 


Cys Ala Val Ser Ser Leu Leu Val Leu Thr Leu Leu Leu Tyr Thr Ala 
705                 710                 715                 720 


Leu Arg Cys Ser Ala Leu Pro Thr Glu Gly Ala Cys Ala Pro Gly Lys 
                725                 730                 735     


Pro Thr Leu Val Cys Ser Ser Ala Val Gly Ser Trp Ser Tyr Ser Gln 
            740                 745                 750         


Gln Arg Arg Pro Arg Val Cys Ser Gly Glu Gly Pro Pro Lys Thr Asp 
        755                 760                 765             


Leu Met Ala Phe Ser Pro Ser Leu Pro Asp Ser Arg Asp Arg Glu Asp 
    770                 775                 780                 


Gln Leu Gln Thr Thr Glu Glu Ser Phe Ala Lys Pro Arg Gln Pro Asn 
785                 790                 795                 800 


Pro Asp Trp Arg Tyr Ser Ala Ser Leu Arg Ala Gly Met His Ser Ser 
                805                 810                 815     


Val His Leu Glu Glu Ala Gly Ile Leu Arg Ala Gly Pro Gly Gly Pro 
            820                 825                 830         


Asp Gln Gln Trp Pro Thr Val Ser Ser Ala Thr Pro Glu Pro Glu Ala 
        835                 840                 845             


Gly Glu Val Ser Pro Pro Val Gly Ala Gly Val Asn Ser Asn Ser Trp 
    850                 855                 860                 


Thr Phe Lys Tyr Gly Pro Gly Asn Pro Lys Gln Ser Gly Pro Glu Pro 
865                 870                 875                 880 


Lys Lys Gln Thr Gln Val Ser Phe Leu Leu Arg Arg Lys Gly Glu Ala 
                885                 890                 895     


Ser Gln Pro Arg Gln 
            900     

<210>  2158
<211>  5436
<212>  DNA
<213>  Homo sapiens

<400>  2158
acaaaataca tgagagaagg aggaagaagg gaaaattcct tctattctta ctggaaggaa     60

ccatatacac tctttggagt ctgaaatatg gaggatgcag ctgcacttga ctgaccgatt    120

aaaagatttc ccttgacttt gagaaacgat atttaatcag aacaaaatac tgtgcactaa    180

agatggagtt ttcctgggga agcggccagg aatcccggcg tctgctgctc ttacttcttc    240

tcctcgcagc ctgggaggca gggaacggtc agctccacta ctcggtctcc gaggaggcca    300

aacacggcac cttcgtgggc cgcatcgcgc aggacctggg actggagctg gcggagctgg    360

tgccgcgcct gttccgggtg gcgtccaagg gccgcggagg ccttctggag gtaaatctgc    420

agaatggcat tttgtttgtg aattctcgga tcgaccggga ggagctgtgc cggcggagcg    480

cggagtgcag catccacctg gaggtgatcg tagacaggcc gctgcaggtt ttccatgtgg    540

acgtggaggt gagggacatt aacgataacc cgccggtgtt cccagcaaca caaaagaacc    600

tgtccatcgc ggaatccagg ccgcttgact ctcggtttcc actagagggc gcctcggatg    660

cagatatcgg ggagaacgcc ctgctcactt acagactgag cccaaatgaa tacttttctc    720

tggaaaaacc acctgatgac gagctggtaa aaggtcttgg gcttatatta cggaaatctt    780

tagacagaga agaagctccg gagatttttt tagtgctcac agccactgat ggaggcaaac    840

ccgagttgac tggcaccgtt cagttactca tcacagtact ggatgccaat gacaatgccc    900

cagcttttga cagaaccatt tataaggtga gattactaga aaatgttcct aatggaacat    960

tggtaattaa acttaacgcc tcagatttag acgaaggatt gaatggggac attgtttatt   1020

cattctcaaa tgatatttcg ccaaatgtga aatccaagtt tcacatagat ccaattactg   1080

gacaaattat tgtaaaggga tatattgact ttgaagaaag caaatcctat gaaattattg   1140

tagagggcat tgataaggga cagctcccac tttctggcca ttgtagagtt attgtggaag   1200

tagaagacaa caacgataat gtcccagatt tggaattcaa gtctttatca cttccaatta   1260

gagaggacgc tccactgggt acagtcatcg ccctgatcag cgtgtccgac aaagacatgg   1320

gtgtcaatgg gctggtcacc tgctccttga cgtcccacgt ccccttcaag ctggtgtcca   1380

ccttcaagaa ttactactcg ttggtgctgg acagtgccct ggaccgcgag agcgtgtcag   1440

cctatgagct ggtggtgacc gcgcgagacg ggggctcgcc ttcgctgtgg gccacggcca   1500

gtgtttctgt ggaggtggct gatgtgaacg acaacgctcc ggcgttcgcg cagcccgagt   1560

acacagtgtt cgtgaaggag aacaacccgc cgggctgcca catcttcact gtgtctgcgt   1620

gggacgcgga cgcgcaggag aacgcgctgg tgtcctactc gctggtagag cggcgggtag   1680

gggagcgcgc gctgtcgagc tacgtttcgg tgcatgcgga gagcggcaag gtgtacgcgc   1740

tgcagccgct ggaccacgag gagctagagc tgctgcagtt tcaggtgacc gctcgcgatg   1800

ccggcgtgcc acctctgggc agcaacgtga cgctgcaggt gttcgtgctg gacgaaaacg   1860

acaacgcgcc agcactgcta gcgcctcggg cgggtggcac tggtggcgca gtgagcgagc   1920

tggtgccatg gtcggtgggt gtgggccacg tggtggcaaa ggtgcgcgcg gtggatgctg   1980

actcgggcta caacgcgtgg ctttcgtacg agctgcagcc ggggactggt ggcgcgcgca   2040

tcccgttccg cgtggggctg tacactggcg agatcagcac aacgcgtgcc ctggacgaaa   2100

cggacgctcc gcgccaccgc ctactggtac tggtgaagga ccacggcgag cccgcgctga   2160

cggccacggc cactgtgctg gtgtcacttg tggagagtgg acaggcgcca aaggcctcct   2220

cacgggcgtt ggtgggcgct gtgggtcccg atgctgcgct ggtggatgtc aacgtatacc   2280

tgatcattgc catctgcgcg gtgtccagcc ttttggtgct cacgctgctg ctgtacaccg   2340

cgctgcggtg ctctgcgctg cccaccgagg gcgcgtgcgc tccgggcaag cccacgctgg   2400

tgtgctccag tgcggtgggg agctggtcat actcgcagca gaggaggccg agggtgtgct   2460

ctggtgaggg cccacccaag accgacctca tggccttcag ccccagttta cctgactcta   2520

gggacagaga agatcagctg cagacaactg aggaatcctt tgcaaagcca cgacagccca   2580

accctgactg gcgttactct gcctccctga gagcaggcat gcacagctct gtgcacctag   2640

aggaggctgg cattctacgg gctggtccag gagggcctga tcagcagtgg ccaacagtat   2700

ccagtgcaac accagaacca gaggcaggag aagtgtcccc tccagtcggt gcgggtgtca   2760

acagcaacag ctggaccttt aaatacggac caggcaaccc caaacaatcc ggtcccggtg   2820

agttgcccga caaattcatt atcccaggat ctcctgcaat catctccatc cggcaggagc   2880

ctactaacag ccaaattgac aaaagtgact tcataacctt cggcaaaaag gaggagacca   2940

agaaaaagaa gaaaaagaag aagggtaaca agacccagga gaaaaaagag aaagggaaca   3000

gcacgactga caacagtgac cagtgaggtc ctcaaatgga aacaagccac ttagccagtt   3060

tttgtaataa tggcaaatct ctcccatgta gcaattccct gctccttttt cctatctaca   3120

tgagccctct tagagacctc agaaatctgc agaaagttcc ctgtgtctgt ctagaacgca   3180

tttaacaggt tttgtcgtaa aagctttact aagtctggtg ttaactcttt ctctccactc   3240

tggcttgttt tcagaaccta aaaagcagac ccaagtttcc tttctcctcc gccgcaaagg   3300

agaggcttcc cagccccgcc agtgagaggt tggactctct gccctgtgct ccggggatcc   3360

tgtcttgatg acacttgcag ggcaggctga aaagttttga gattgagcag cttgggagtt   3420

tgtggccact gggtatgtgt ggctaccgcg ggtatgcgag tgccagatat tggctgagac   3480

gagccagctt agactaattg gtacaaggaa ggcaagaaaa caaagacaaa taaacagcgg   3540

aagttatcag tatggagggg aagtgtaaac ttaaagggac cagactttct aaatcttaca   3600

actcaagagg tggcagccac cctctaggag acaaaactac ccccactgac aaggctttag   3660

gagaccctaa agtctgttgg ctgtgacgtc attataccta aaatctgcat catacctgca   3720

agccaacagt tcagtgtttt aacagagaac caccctggga aacagaagca gatctgatgt   3780

gtttcctata catgtcctgt gctcacttta ttaaaaattc ttttgcacac aatgtttatg   3840

aaaaggccag atccttttcc aatacttatg caaaagcaaa agaaaacccc gacacctcac   3900

ctttcgctgt ttgttgtttc atagatttat ttaaaaaaag agaaagtcta tagctataaa   3960

tctttaaaga gaaatatgaa tacaattccc ctaaactctc ctcaaaagag aattcagtct   4020

acagccattt aaatgatcat tgctgctaca gaagtgcttt aagagaattg cctgaaacat   4080

ctgtattata tcggccacct gccaatcaca gctttactct ttcaggtcac tctggggctg   4140

cctcttgcat gtattactaa ataaaatgat ctctctttct ctctctctct ctcttttcta   4200

agaaacaatt atgtgcactt tgatacacaa ccttctctaa ccaactatat atcaagaccc   4260

aaaaattgaa gaaaaatatt gttttctcat acagtgagca gatttttcaa tctactaatt   4320

ctgtgacttg tcttggtgtg ctagcctaca ccttctcttt ggtttagttt tccttttcta   4380

taacactctg aattgctaat cttactaaca cctatgatgt tacctgaaat caatctccca   4440

tatgtatgct gtatgctatg ctaagactcc tgaaatatac ttactctgtg cttgtgtatg   4500

tgaatgttaa tgcaactatt acctagagtg aactttaagc tttattgttg aatgtaattc   4560

cattatattt ccttttgtac acctgtgaaa aagtggagta gtgttttttt aaccattgtt   4620

aatcagcttt tgtgtatgaa agacacagta aaatttcttt cttaaatcaa gatactggtg   4680

attcaaggaa ttttatttat ggtccagcca agagccatct cgtgccaaga cttctgctgg   4740

caagggaatg gataaagctg ttttgttcta gtaacaattt tggaatgaat actgacaata   4800

ttccatgagg gtgtgcaagc acaaatttta ccaatctgac ctctttgaag ttgcagaatg   4860

ctttgaaatt ctaatggtat ctgaaatatc agctcataga aagtaacaaa atttgctgtc   4920

accttaaata agacatttta attttgttat aatgtacaat ttagaagttt gattaattat   4980

attatctatt taggcattaa tataaaagag gtaggagtct gttatttaaa aaaagcatta   5040

aatttaaaaa aaaactgtct tgtctacttt tagcttcatt ctcccatatt ttgaagggtg   5100

tgtaacttca gctctgcagg attgcatggg gtaaaacttg ttaccaacac atgtgaacca   5160

ttgctacatt gtaggttgtg atcattttgc cccactgaag cccatgtatc tgaccttacg   5220

tgccttttga actaggagaa tcgggctaat ttattaatga tgataattat aatgtatctg   5280

tacagcactt tttacatttg cgaagtgctt tccaatccat gttagttact agttattaca   5340

gctgtaagga taaaacacgt catgtggatt cattttgaat tggtgctatt ggtatttcct   5400

ctgttattgc taataaatga aaatggtggt atgaaa                             5436


<210>  2159
<211>  947
<212>  PRT
<213>  Homo sapiens

<400>  2159


Met Glu Phe Ser Trp Gly Ser Gly Gln Glu Ser Arg Arg Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Ala Ala Trp Glu Ala Gly Asn Gly Gln Leu His 
            20                  25                  30          


Tyr Ser Val Ser Glu Glu Ala Lys His Gly Thr Phe Val Gly Arg Ile 
        35                  40                  45              


Ala Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Pro Arg Leu Phe 
    50                  55                  60                  


Arg Val Ala Ser Lys Gly Arg Gly Gly Leu Leu Glu Val Asn Leu Gln 
65                  70                  75                  80  


Asn Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Arg Arg Ser Ala Glu Cys Ser Ile His Leu Glu Val Ile Val Asp Arg 
            100                 105                 110         


Pro Leu Gln Val Phe His Val Asp Val Glu Val Arg Asp Ile Asn Asp 
        115                 120                 125             


Asn Pro Pro Val Phe Pro Ala Thr Gln Lys Asn Leu Ser Ile Ala Glu 
    130                 135                 140                 


Ser Arg Pro Leu Asp Ser Arg Phe Pro Leu Glu Gly Ala Ser Asp Ala 
145                 150                 155                 160 


Asp Ile Gly Glu Asn Ala Leu Leu Thr Tyr Arg Leu Ser Pro Asn Glu 
                165                 170                 175     


Tyr Phe Ser Leu Glu Lys Pro Pro Asp Asp Glu Leu Val Lys Gly Leu 
            180                 185                 190         


Gly Leu Ile Leu Arg Lys Ser Leu Asp Arg Glu Glu Ala Pro Glu Ile 
        195                 200                 205             


Phe Leu Val Leu Thr Ala Thr Asp Gly Gly Lys Pro Glu Leu Thr Gly 
    210                 215                 220                 


Thr Val Gln Leu Leu Ile Thr Val Leu Asp Ala Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Ala Phe Asp Arg Thr Ile Tyr Lys Val Arg Leu Leu Glu Asn Val Pro 
                245                 250                 255     


Asn Gly Thr Leu Val Ile Lys Leu Asn Ala Ser Asp Leu Asp Glu Gly 
            260                 265                 270         


Leu Asn Gly Asp Ile Val Tyr Ser Phe Ser Asn Asp Ile Ser Pro Asn 
        275                 280                 285             


Val Lys Ser Lys Phe His Ile Asp Pro Ile Thr Gly Gln Ile Ile Val 
    290                 295                 300                 


Lys Gly Tyr Ile Asp Phe Glu Glu Ser Lys Ser Tyr Glu Ile Ile Val 
305                 310                 315                 320 


Glu Gly Ile Asp Lys Gly Gln Leu Pro Leu Ser Gly His Cys Arg Val 
                325                 330                 335     


Ile Val Glu Val Glu Asp Asn Asn Asp Asn Val Pro Asp Leu Glu Phe 
            340                 345                 350         


Lys Ser Leu Ser Leu Pro Ile Arg Glu Asp Ala Pro Leu Gly Thr Val 
        355                 360                 365             


Ile Ala Leu Ile Ser Val Ser Asp Lys Asp Met Gly Val Asn Gly Leu 
    370                 375                 380                 


Val Thr Cys Ser Leu Thr Ser His Val Pro Phe Lys Leu Val Ser Thr 
385                 390                 395                 400 


Phe Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu 
                405                 410                 415     


Ser Val Ser Ala Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser 
            420                 425                 430         


Pro Ser Leu Trp Ala Thr Ala Ser Val Ser Val Glu Val Ala Asp Val 
        435                 440                 445             


Asn Asp Asn Ala Pro Ala Phe Ala Gln Pro Glu Tyr Thr Val Phe Val 
    450                 455                 460                 


Lys Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Trp 
465                 470                 475                 480 


Asp Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu 
                485                 490                 495     


Arg Arg Val Gly Glu Arg Ala Leu Ser Ser Tyr Val Ser Val His Ala 
            500                 505                 510         


Glu Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu 
        515                 520                 525             


Glu Leu Leu Gln Phe Gln Val Thr Ala Arg Asp Ala Gly Val Pro Pro 
    530                 535                 540                 


Leu Gly Ser Asn Val Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp 
545                 550                 555                 560 


Asn Ala Pro Ala Leu Leu Ala Pro Arg Ala Gly Gly Thr Gly Gly Ala 
                565                 570                 575     


Val Ser Glu Leu Val Pro Trp Ser Val Gly Val Gly His Val Val Ala 
            580                 585                 590         


Lys Val Arg Ala Val Asp Ala Asp Ser Gly Tyr Asn Ala Trp Leu Ser 
        595                 600                 605             


Tyr Glu Leu Gln Pro Gly Thr Gly Gly Ala Arg Ile Pro Phe Arg Val 
    610                 615                 620                 


Gly Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Ala Leu Asp Glu Thr 
625                 630                 635                 640 


Asp Ala Pro Arg His Arg Leu Leu Val Leu Val Lys Asp His Gly Glu 
                645                 650                 655     


Pro Ala Leu Thr Ala Thr Ala Thr Val Leu Val Ser Leu Val Glu Ser 
            660                 665                 670         


Gly Gln Ala Pro Lys Ala Ser Ser Arg Ala Leu Val Gly Ala Val Gly 
        675                 680                 685             


Pro Asp Ala Ala Leu Val Asp Val Asn Val Tyr Leu Ile Ile Ala Ile 
    690                 695                 700                 


Cys Ala Val Ser Ser Leu Leu Val Leu Thr Leu Leu Leu Tyr Thr Ala 
705                 710                 715                 720 


Leu Arg Cys Ser Ala Leu Pro Thr Glu Gly Ala Cys Ala Pro Gly Lys 
                725                 730                 735     


Pro Thr Leu Val Cys Ser Ser Ala Val Gly Ser Trp Ser Tyr Ser Gln 
            740                 745                 750         


Gln Arg Arg Pro Arg Val Cys Ser Gly Glu Gly Pro Pro Lys Thr Asp 
        755                 760                 765             


Leu Met Ala Phe Ser Pro Ser Leu Pro Asp Ser Arg Asp Arg Glu Asp 
    770                 775                 780                 


Gln Leu Gln Thr Thr Glu Glu Ser Phe Ala Lys Pro Arg Gln Pro Asn 
785                 790                 795                 800 


Pro Asp Trp Arg Tyr Ser Ala Ser Leu Arg Ala Gly Met His Ser Ser 
                805                 810                 815     


Val His Leu Glu Glu Ala Gly Ile Leu Arg Ala Gly Pro Gly Gly Pro 
            820                 825                 830         


Asp Gln Gln Trp Pro Thr Val Ser Ser Ala Thr Pro Glu Pro Glu Ala 
        835                 840                 845             


Gly Glu Val Ser Pro Pro Val Gly Ala Gly Val Asn Ser Asn Ser Trp 
    850                 855                 860                 


Thr Phe Lys Tyr Gly Pro Gly Asn Pro Lys Gln Ser Gly Pro Gly Glu 
865                 870                 875                 880 


Leu Pro Asp Lys Phe Ile Ile Pro Gly Ser Pro Ala Ile Ile Ser Ile 
                885                 890                 895     


Arg Gln Glu Pro Thr Asn Ser Gln Ile Asp Lys Ser Asp Phe Ile Thr 
            900                 905                 910         


Phe Gly Lys Lys Glu Glu Thr Lys Lys Lys Lys Lys Lys Lys Lys Gly 
        915                 920                 925             


Asn Lys Thr Gln Glu Lys Lys Glu Lys Gly Asn Ser Thr Thr Asp Asn 
    930                 935                 940                 


Ser Asp Gln 
945         

<210>  2160
<211>  2265
<212>  DNA
<213>  Homo sapiens

<400>  2160
gctccagtgc ggtggggagc tggtcatact cgcagcagag gaggccgagg gtgtgctctg     60

gtgagggccc acccaagacc gacctcatgg ccttcagccc cagtttacct gactctaggg    120

acagagaaga tcagctgcag acaactgagg aatcctttgc aaagccacga cagcccaacc    180

ctgactggcg ttactctgcc tccctgagag caggcatgca cagctctgtg cacctagagg    240

aggctggcat tctacgggct ggtccaggag ggcctgatca gcagtggcca acagtatcca    300

gtgcaacacc agaaccagag gcaggagaag tgtcccctcc agtcggtgcg ggtgtcaaca    360

gcaacagctg gacctttaaa tacggaccag gcaaccccaa acaatccggt cccggtgagt    420

tgcccgacaa attcattatc ccaggatctc ctgcaatcat ctccatccgg caggagccta    480

ctaacagcca aattgacaaa agtgacttca taaccttcgg caaaaaggag gagaccaaga    540

aaaagaagaa aaagaagaag ggtaacaaga cccaggagaa aaaagagaaa gggaacagca    600

cgactgacaa cagtgaccag tgaggtcctc aaatggaaac aagccactta gccagttttt    660

gtaataatgg caaatctctc ccatgtagca attccctgct cctttttcct atctacatga    720

gccctcttag agacctcaga aatctgcaga aagttccctg tgtctgtcta gaacgcattt    780

aacaggtttt gtcgtaaaag ctttactaag tctggtgtta actctttctc tccactctgg    840

cttgttttca gaacctaaaa agcagaccca agtttccttt ctcctccgcc gcaaaggaga    900

ggcttcccag ccccgccagt gagaggttgg actctctgcc ctgtgctccg gggatcctgt    960

cttgatgaca cttgcagggc aggctgaaaa gttttgagat tgagcagctt gggagtttgt   1020

ggccactggg tatgtgtggc taccgcgggt atgcgagtgc cagatattgg ctgagacgag   1080

ccagcttaga ctaattggta caaggaaggc aagaaaacaa agacaaataa acagcggaag   1140

ttatcagtat ggaggggaag tgtaaactta aagggaccag actttctaaa tcttacaact   1200

caagaggtgg cagccaccct ctaggagaca aaactacccc cactgacaag gctttaggag   1260

accctaaagt ctgttggctg tgacgtcatt atacctaaaa tctgcatcat acctgcaagc   1320

caacagttca gtgttttaac agagaaccac cctgggaaac agaagcagat ctgatgtgtt   1380

tcctatacat gtcctgtgct cactttatta aaaattcttt tgcacacaat gtttatgaaa   1440

aggccagatc cttttccaat acttatgcaa aagcaaaaga aaaccccgac acctcacctt   1500

tcgctgtttg ttgtttcata gatttattta aaaaaagaga aagtctatag ctataaatct   1560

ttaaagagaa atatgaatac aattccccta aactctcctc aaaagagaat tcagtctaca   1620

gccatttaaa tgatcattgc tgctacagaa gtgctttaag agaattgcct gaaacatctg   1680

tattatatcg gccacctgcc aatcacagct ttactctttc aggtcactct ggggctgcct   1740

cttgcatgta ttactaaata aaatgatctc tctttctctc tctctctctc ttttctaaga   1800

aacaattatg tgcactttga tacacaacct tctctaacca actatatatc aagacccaaa   1860

aattgaagaa aaatattgtt ttctcataca gtgagcagat ttttcaatct actaattctg   1920

tgacttgtct tggtgtgcta gcctacacct tctctttggt ttagttttcc ttttctataa   1980

cactctgaat tgctaatctt actaacacct atgatgttac ctgaaatcaa tctcccatat   2040

gtatgctgta tgctatgcta agactcctga aatatactta ctctgtgctt gtgtatgtga   2100

atgttaatgc aactattacc tagagtgaac tttaagcttt attgttgaat gtaattccat   2160

tatatttcct tttgtacacc tgtgaaaaag tggagtagtg tttttttaac cattgttaat   2220

cagcttttgt gtatgaaaga cacagtaaaa tttctttctt aaatc                   2265


<210>  2161
<211>  178
<212>  PRT
<213>  Homo sapiens

<400>  2161


Met Ala Phe Ser Pro Ser Leu Pro Asp Ser Arg Asp Arg Glu Asp Gln 
1               5                   10                  15      


Leu Gln Thr Thr Glu Glu Ser Phe Ala Lys Pro Arg Gln Pro Asn Pro 
            20                  25                  30          


Asp Trp Arg Tyr Ser Ala Ser Leu Arg Ala Gly Met His Ser Ser Val 
        35                  40                  45              


His Leu Glu Glu Ala Gly Ile Leu Arg Ala Gly Pro Gly Gly Pro Asp 
    50                  55                  60                  


Gln Gln Trp Pro Thr Val Ser Ser Ala Thr Pro Glu Pro Glu Ala Gly 
65                  70                  75                  80  


Glu Val Ser Pro Pro Val Gly Ala Gly Val Asn Ser Asn Ser Trp Thr 
                85                  90                  95      


Phe Lys Tyr Gly Pro Gly Asn Pro Lys Gln Ser Gly Pro Gly Glu Leu 
            100                 105                 110         


Pro Asp Lys Phe Ile Ile Pro Gly Ser Pro Ala Ile Ile Ser Ile Arg 
        115                 120                 125             


Gln Glu Pro Thr Asn Ser Gln Ile Asp Lys Ser Asp Phe Ile Thr Phe 
    130                 135                 140                 


Gly Lys Lys Glu Glu Thr Lys Lys Lys Lys Lys Lys Lys Lys Gly Asn 
145                 150                 155                 160 


Lys Thr Gln Glu Lys Lys Glu Lys Gly Asn Ser Thr Thr Asp Asn Ser 
                165                 170                 175     


Asp Gln 
        

<210>  2162
<211>  4188
<212>  DNA
<213>  Homo sapiens

<400>  2162
acagtgagta gattttcctt agacagaaag gaaaagaacc ttccattttt ggctgtgcca     60

agaagctcag aaaggcgata atataaaaaa tatatagtta attgggaatt gaatttacaa    120

aatacattgt gtggtgatgc aatagaaagc tcataattgg aacgagattg agatggtata    180

ttcccggaga ggaagtctgg gatcccggct cctgctgctc tggcttctcc ttgcctactg    240

gaaggcaggg agcggccagc tccactactc gatcccggag gaagccaaac acggaacctt    300

cgttggccgc atcgcgcagg acctagggct ggagctggcg gagctggtgc cgcgcctgtt    360

ccgggtggcg tccaagggcc gcggggacct tctggaggta aatctgcaga atggcatttt    420

gtttgtgaat tctcggatcg accgggagga gctgtgccgg cggagggcgg agtgcagcat    480

ccacctggag gtgatcgtgg acaggccgct gcaggttttc catgtggagg tggcagtgaa    540

ggacatcaat gacaatccgc ccaggttctc cagacaagaa caaagattat tcattttaga    600

gtcaagaatg ccagattcgc ggtttccgct agagggcgcg tcggatttgg atattggagc    660

aaatgcacaa ttgagataca ggttaaatcc aaacgaatat tttgacttag atgttaaaac    720

aaatgaagaa gaaacgaact ttttagagct ggttttgagg aaatccttag atagagaaga    780

aacacaagaa caccgtttat tagtgattgc aactgatgga ggaaaacccg aactaacagg    840

tacagttcag ttgttgatca atgtattgga tgctaatgat aacgccccag aatttgataa    900

atccatttat aatgtcagat tgttggaaaa tgcaccaagt gggacattag ttattaaact    960

gaacgcctca gatgcagatg agggcatcaa taaggaaata gtgtatttct ttagtaatct   1020

tgttcttgac gatgtaaagt ccaaatttat aattaattct aatactggtg aaataaaagt   1080

taacggggaa ctggattatg aagactataa ctcatatgaa attaatattg atgccatgga   1140

taaaagtaca ttcccattat caggacactg taaagtagta gtgaaactcc tggatgtgaa   1200

tgataatacc ccagagatgg ccataaccac ccttttcctg cctgtcaaag aggacgctcc   1260

actcagcacg gtcattgctc tgatcagcgt gtctgaccgt gactcaggtg ccaacgggca   1320

ggtgacctgc tccctaatgc cccacgttcc cttcaagctg gtgtccacct tcaagaatta   1380

ctactcgttg gtgctggaca gcgccctgga ccgcgagagc gtgtcggtct atgagctggt   1440

ggtgaccgcg cgggacgggg gctcgccttc gctgtgggcc accgccagcg tgtctgtgga   1500

agtggccgac gtgaacgaca acgctccggc gttcgcgcag ccccagtata ccgtgttcgt   1560

gaaggagaac aacccgccag gctgccacat cttcacggtg tctgcacggg acgcggacgc   1620

gcaggagaac gccctggtgt cctactcgct ggtggagcgg cgggtgggcg agcgcccgct   1680

gtcgagttac gtttcggtgc acgcggagag cggcaaggtg tacgcgctgc agccgctgga   1740

ccacgaggaa gtggagctgc tgcagttcca ggtgagcgcg cgcgacgcgg gcgtgccgcc   1800

tctgggcagc aacgtgacgc tgcaggtgtt cgtgctggac gagaacgaca acgcgccggc   1860

gctgctggtg cctcgagtgg gtggcaccgg cggcgcagtg agcgagctgg tgccgaggtc   1920

agtgggtgcg ggccacgtgg tggcgaaggt gcgcgcagtg gaccctgatt cgggctacaa   1980

cgcttggctt tcgtatgagc tgcagccagc gcctggcagt gcgcgcatcc cgttccgcgt   2040

ggggctgtac acaggcgaga tcagcacaac acgctctctg gatgagaccg aagcaccgcg   2100

ccaccgcctt ctggtgctgg tgaaggacca tggagagccc ccgctgacag ccacagccac   2160

agtgctggtg tcgctggtgg aaagtggcca ggcgccgaag gcctcatcgc gggcgtcggc   2220

gggcgctgtg ggtcccgagg ctgccctggt ggatgtcaac gtgtacctga tcatcgccat   2280

ctgtgcggtg tccagcctgc tggtgctcac gctgctgctg tacaccgcgc tgcggtgctc   2340

ggcgcagccc accgaggccg tgtgcacacg gggcaagccc actctgttgt gctccagcgc   2400

ggtggggagc tggtcgtact cgcagcagag gagacagagg gtgtgctctg gggaagctcc   2460

acccaaaaca gacctcatgg ccttcagtcc aagccttcct cagggtccca cctctacaga   2520

caacccacga cagcccaacc ctgactggcg ttactctgcc tccctgagag caggcatgca   2580

cagctctgtg cacctagagg aggctggcat tctacgggct ggtccaggag ggcctgatca   2640

gcagtggcca acagtatcca gtgcaacacc agaaccagag gcaggagaag tgtcccctcc   2700

agtcggtgcg ggtgtcaaca gcaacagctg gacctttaaa tacggaccag gcaaccccaa   2760

acaatccggt cccgaaccta aaaagcagac ccaagtttcc tttctcctcc gccgcaaagg   2820

agaggcttcc cagccccgcc agtgagaggt tggactctct gccctgtgct ccggggatcc   2880

tgtcttgatg acacttgcag ggcaggctga aaagttttga gattgagcag cttgggagtt   2940

tgtggccact gggtatgtgt ggctaccgcg ggtatgcgag tgccagatat tggctgagac   3000

gagccagctt agactaattg gtacaaggaa ggcaagaaaa caaagacaaa taaacagcgg   3060

aagttatcag tatggagggg aagtgtaaac ttaaagggac cagactttct aaatcttaca   3120

actcaagagg tggcagccac cctctaggag acaaaactac ccccactgac aaggctttag   3180

gagaccctaa agtctgttgg ctgtgacgtc attataccta aaatctgcat catacctgca   3240

agccaacagt tcagtgtttt aacagagaac caccctggga aacagaagca gatctgatgt   3300

gtttcctata catgtcctgt gctcacttta ttaaaaattc ttttgcacac aatgtttatg   3360

aaaaggccag atccttttcc aatacttatg caaaagcaaa agaaaacccc gacacctcac   3420

ctttcgctgt ttgttgtttc atagatttat ttaaaaaaag agaaagtcta tagctataaa   3480

tctttaaaga gaaatatgaa tacaattccc ctaaactctc ctcaaaagag aattcagtct   3540

acagccattt aaatgatcat tgctgctaca gaagtgcttt aagagaattg cctgaaacat   3600

ctgtattata tcggccacct gccaatcaca gctttactct ttcaggtcac tctggggctg   3660

cctcttgcat gtattactaa ataaaatgat ctctctttct ctctctctct ctcttttcta   3720

agaaacaatt atgtgcactt tgatacacaa ccttctctaa ccaactatat atcaagaccc   3780

aaaaattgaa gaaaaatatt gttttctcat acagtgagca gatttttcaa tctactaatt   3840

ctgtgacttg tcttggtgtg ctagcctaca ccttctcttt ggtttagttt tccttttcta   3900

taacactctg aattgctaat cttactaaca cctatgatgt tacctgaaat caatctccca   3960

tatgtatgct gtatgctatg ctaagactcc tgaaatatac ttactctgtg cttgtgtatg   4020

tgaatgttaa tgcaactatt acctagagtg aactttaagc tttattgttg aatgtaattc   4080

cattatattt ccttttgtac acctgtgaaa aagtggagta gtgttttttt aaccattgtt   4140

aatcagcttt tgtgtatgaa agacacagta aaatttcttt cttaaatc                4188


<210>  2163
<211>  890
<212>  PRT
<213>  Homo sapiens

<400>  2163


Met Val Tyr Ser Arg Arg Gly Ser Leu Gly Ser Arg Leu Leu Leu Leu 
1               5                   10                  15      


Trp Leu Leu Leu Ala Tyr Trp Lys Ala Gly Ser Gly Gln Leu His Tyr 
            20                  25                  30          


Ser Ile Pro Glu Glu Ala Lys His Gly Thr Phe Val Gly Arg Ile Ala 
        35                  40                  45              


Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Pro Arg Leu Phe Arg 
    50                  55                  60                  


Val Ala Ser Lys Gly Arg Gly Asp Leu Leu Glu Val Asn Leu Gln Asn 
65                  70                  75                  80  


Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys Arg 
                85                  90                  95      


Arg Arg Ala Glu Cys Ser Ile His Leu Glu Val Ile Val Asp Arg Pro 
            100                 105                 110         


Leu Gln Val Phe His Val Glu Val Ala Val Lys Asp Ile Asn Asp Asn 
        115                 120                 125             


Pro Pro Arg Phe Ser Arg Gln Glu Gln Arg Leu Phe Ile Leu Glu Ser 
    130                 135                 140                 


Arg Met Pro Asp Ser Arg Phe Pro Leu Glu Gly Ala Ser Asp Leu Asp 
145                 150                 155                 160 


Ile Gly Ala Asn Ala Gln Leu Arg Tyr Arg Leu Asn Pro Asn Glu Tyr 
                165                 170                 175     


Phe Asp Leu Asp Val Lys Thr Asn Glu Glu Glu Thr Asn Phe Leu Glu 
            180                 185                 190         


Leu Val Leu Arg Lys Ser Leu Asp Arg Glu Glu Thr Gln Glu His Arg 
        195                 200                 205             


Leu Leu Val Ile Ala Thr Asp Gly Gly Lys Pro Glu Leu Thr Gly Thr 
    210                 215                 220                 


Val Gln Leu Leu Ile Asn Val Leu Asp Ala Asn Asp Asn Ala Pro Glu 
225                 230                 235                 240 


Phe Asp Lys Ser Ile Tyr Asn Val Arg Leu Leu Glu Asn Ala Pro Ser 
                245                 250                 255     


Gly Thr Leu Val Ile Lys Leu Asn Ala Ser Asp Ala Asp Glu Gly Ile 
            260                 265                 270         


Asn Lys Glu Ile Val Tyr Phe Phe Ser Asn Leu Val Leu Asp Asp Val 
        275                 280                 285             


Lys Ser Lys Phe Ile Ile Asn Ser Asn Thr Gly Glu Ile Lys Val Asn 
    290                 295                 300                 


Gly Glu Leu Asp Tyr Glu Asp Tyr Asn Ser Tyr Glu Ile Asn Ile Asp 
305                 310                 315                 320 


Ala Met Asp Lys Ser Thr Phe Pro Leu Ser Gly His Cys Lys Val Val 
                325                 330                 335     


Val Lys Leu Leu Asp Val Asn Asp Asn Thr Pro Glu Met Ala Ile Thr 
            340                 345                 350         


Thr Leu Phe Leu Pro Val Lys Glu Asp Ala Pro Leu Ser Thr Val Ile 
        355                 360                 365             


Ala Leu Ile Ser Val Ser Asp Arg Asp Ser Gly Ala Asn Gly Gln Val 
    370                 375                 380                 


Thr Cys Ser Leu Met Pro His Val Pro Phe Lys Leu Val Ser Thr Phe 
385                 390                 395                 400 


Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu Ser 
                405                 410                 415     


Val Ser Val Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser Pro 
            420                 425                 430         


Ser Leu Trp Ala Thr Ala Ser Val Ser Val Glu Val Ala Asp Val Asn 
        435                 440                 445             


Asp Asn Ala Pro Ala Phe Ala Gln Pro Gln Tyr Thr Val Phe Val Lys 
    450                 455                 460                 


Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Arg Asp 
465                 470                 475                 480 


Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu Arg 
                485                 490                 495     


Arg Val Gly Glu Arg Pro Leu Ser Ser Tyr Val Ser Val His Ala Glu 
            500                 505                 510         


Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Val Glu 
        515                 520                 525             


Leu Leu Gln Phe Gln Val Ser Ala Arg Asp Ala Gly Val Pro Pro Leu 
    530                 535                 540                 


Gly Ser Asn Val Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp Asn 
545                 550                 555                 560 


Ala Pro Ala Leu Leu Val Pro Arg Val Gly Gly Thr Gly Gly Ala Val 
                565                 570                 575     


Ser Glu Leu Val Pro Arg Ser Val Gly Ala Gly His Val Val Ala Lys 
            580                 585                 590         


Val Arg Ala Val Asp Pro Asp Ser Gly Tyr Asn Ala Trp Leu Ser Tyr 
        595                 600                 605             


Glu Leu Gln Pro Ala Pro Gly Ser Ala Arg Ile Pro Phe Arg Val Gly 
    610                 615                 620                 


Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Ser Leu Asp Glu Thr Glu 
625                 630                 635                 640 


Ala Pro Arg His Arg Leu Leu Val Leu Val Lys Asp His Gly Glu Pro 
                645                 650                 655     


Pro Leu Thr Ala Thr Ala Thr Val Leu Val Ser Leu Val Glu Ser Gly 
            660                 665                 670         


Gln Ala Pro Lys Ala Ser Ser Arg Ala Ser Ala Gly Ala Val Gly Pro 
        675                 680                 685             


Glu Ala Ala Leu Val Asp Val Asn Val Tyr Leu Ile Ile Ala Ile Cys 
    690                 695                 700                 


Ala Val Ser Ser Leu Leu Val Leu Thr Leu Leu Leu Tyr Thr Ala Leu 
705                 710                 715                 720 


Arg Cys Ser Ala Gln Pro Thr Glu Ala Val Cys Thr Arg Gly Lys Pro 
                725                 730                 735     


Thr Leu Leu Cys Ser Ser Ala Val Gly Ser Trp Ser Tyr Ser Gln Gln 
            740                 745                 750         


Arg Arg Gln Arg Val Cys Ser Gly Glu Ala Pro Pro Lys Thr Asp Leu 
        755                 760                 765             


Met Ala Phe Ser Pro Ser Leu Pro Gln Gly Pro Thr Ser Thr Asp Asn 
    770                 775                 780                 


Pro Arg Gln Pro Asn Pro Asp Trp Arg Tyr Ser Ala Ser Leu Arg Ala 
785                 790                 795                 800 


Gly Met His Ser Ser Val His Leu Glu Glu Ala Gly Ile Leu Arg Ala 
                805                 810                 815     


Gly Pro Gly Gly Pro Asp Gln Gln Trp Pro Thr Val Ser Ser Ala Thr 
            820                 825                 830         


Pro Glu Pro Glu Ala Gly Glu Val Ser Pro Pro Val Gly Ala Gly Val 
        835                 840                 845             


Asn Ser Asn Ser Trp Thr Phe Lys Tyr Gly Pro Gly Asn Pro Lys Gln 
    850                 855                 860                 


Ser Gly Pro Glu Pro Lys Lys Gln Thr Gln Val Ser Phe Leu Leu Arg 
865                 870                 875                 880 


Arg Lys Gly Glu Ala Ser Gln Pro Arg Gln 
                885                 890 

<210>  2164
<211>  5393
<212>  DNA
<213>  Homo sapiens

<400>  2164
acagtgagta gattttcctt agacagaaag gaaaagaacc ttccattttt ggctgtgcca     60

agaagctcag aaaggcgata atataaaaaa tatatagtta attgggaatt gaatttacaa    120

aatacattgt gtggtgatgc aatagaaagc tcataattgg aacgagattg agatggtata    180

ttcccggaga ggaagtctgg gatcccggct cctgctgctc tggcttctcc ttgcctactg    240

gaaggcaggg agcggccagc tccactactc gatcccggag gaagccaaac acggaacctt    300

cgttggccgc atcgcgcagg acctagggct ggagctggcg gagctggtgc cgcgcctgtt    360

ccgggtggcg tccaagggcc gcggggacct tctggaggta aatctgcaga atggcatttt    420

gtttgtgaat tctcggatcg accgggagga gctgtgccgg cggagggcgg agtgcagcat    480

ccacctggag gtgatcgtgg acaggccgct gcaggttttc catgtggagg tggcagtgaa    540

ggacatcaat gacaatccgc ccaggttctc cagacaagaa caaagattat tcattttaga    600

gtcaagaatg ccagattcgc ggtttccgct agagggcgcg tcggatttgg atattggagc    660

aaatgcacaa ttgagataca ggttaaatcc aaacgaatat tttgacttag atgttaaaac    720

aaatgaagaa gaaacgaact ttttagagct ggttttgagg aaatccttag atagagaaga    780

aacacaagaa caccgtttat tagtgattgc aactgatgga ggaaaacccg aactaacagg    840

tacagttcag ttgttgatca atgtattgga tgctaatgat aacgccccag aatttgataa    900

atccatttat aatgtcagat tgttggaaaa tgcaccaagt gggacattag ttattaaact    960

gaacgcctca gatgcagatg agggcatcaa taaggaaata gtgtatttct ttagtaatct   1020

tgttcttgac gatgtaaagt ccaaatttat aattaattct aatactggtg aaataaaagt   1080

taacggggaa ctggattatg aagactataa ctcatatgaa attaatattg atgccatgga   1140

taaaagtaca ttcccattat caggacactg taaagtagta gtgaaactcc tggatgtgaa   1200

tgataatacc ccagagatgg ccataaccac ccttttcctg cctgtcaaag aggacgctcc   1260

actcagcacg gtcattgctc tgatcagcgt gtctgaccgt gactcaggtg ccaacgggca   1320

ggtgacctgc tccctaatgc cccacgttcc cttcaagctg gtgtccacct tcaagaatta   1380

ctactcgttg gtgctggaca gcgccctgga ccgcgagagc gtgtcggtct atgagctggt   1440

ggtgaccgcg cgggacgggg gctcgccttc gctgtgggcc accgccagcg tgtctgtgga   1500

agtggccgac gtgaacgaca acgctccggc gttcgcgcag ccccagtata ccgtgttcgt   1560

gaaggagaac aacccgccag gctgccacat cttcacggtg tctgcacggg acgcggacgc   1620

gcaggagaac gccctggtgt cctactcgct ggtggagcgg cgggtgggcg agcgcccgct   1680

gtcgagttac gtttcggtgc acgcggagag cggcaaggtg tacgcgctgc agccgctgga   1740

ccacgaggaa gtggagctgc tgcagttcca ggtgagcgcg cgcgacgcgg gcgtgccgcc   1800

tctgggcagc aacgtgacgc tgcaggtgtt cgtgctggac gagaacgaca acgcgccggc   1860

gctgctggtg cctcgagtgg gtggcaccgg cggcgcagtg agcgagctgg tgccgaggtc   1920

agtgggtgcg ggccacgtgg tggcgaaggt gcgcgcagtg gaccctgatt cgggctacaa   1980

cgcttggctt tcgtatgagc tgcagccagc gcctggcagt gcgcgcatcc cgttccgcgt   2040

ggggctgtac acaggcgaga tcagcacaac acgctctctg gatgagaccg aagcaccgcg   2100

ccaccgcctt ctggtgctgg tgaaggacca tggagagccc ccgctgacag ccacagccac   2160

agtgctggtg tcgctggtgg aaagtggcca ggcgccgaag gcctcatcgc gggcgtcggc   2220

gggcgctgtg ggtcccgagg ctgccctggt ggatgtcaac gtgtacctga tcatcgccat   2280

ctgtgcggtg tccagcctgc tggtgctcac gctgctgctg tacaccgcgc tgcggtgctc   2340

ggcgcagccc accgaggccg tgtgcacacg gggcaagccc actctgttgt gctccagcgc   2400

ggtggggagc tggtcgtact cgcagcagag gagacagagg gtgtgctctg gggaagctcc   2460

acccaaaaca gacctcatgg ccttcagtcc aagccttcct cagggtccca cctctacaga   2520

caacccacga cagcccaacc ctgactggcg ttactctgcc tccctgagag caggcatgca   2580

cagctctgtg cacctagagg aggctggcat tctacgggct ggtccaggag ggcctgatca   2640

gcagtggcca acagtatcca gtgcaacacc agaaccagag gcaggagaag tgtcccctcc   2700

agtcggtgcg ggtgtcaaca gcaacagctg gacctttaaa tacggaccag gcaaccccaa   2760

acaatccggt cccggtgagt tgcccgacaa attcattatc ccaggatctc ctgcaatcat   2820

ctccatccgg caggagccta ctaacagcca aattgacaaa agtgacttca taaccttcgg   2880

caaaaaggag gagaccaaga aaaagaagaa aaagaagaag ggtaacaaga cccaggagaa   2940

aaaagagaaa gggaacagca cgactgacaa cagtgaccag tgaggtcctc aaatggaaac   3000

aagccactta gccagttttt gtaataatgg caaatctctc ccatgtagca attccctgct   3060

cctttttcct atctacatga gccctcttag agacctcaga aatctgcaga aagttccctg   3120

tgtctgtcta gaacgcattt aacaggtttt gtcgtaaaag ctttactaag tctggtgtta   3180

actctttctc tccactctgg cttgttttca gaacctaaaa agcagaccca agtttccttt   3240

ctcctccgcc gcaaaggaga ggcttcccag ccccgccagt gagaggttgg actctctgcc   3300

ctgtgctccg gggatcctgt cttgatgaca cttgcagggc aggctgaaaa gttttgagat   3360

tgagcagctt gggagtttgt ggccactggg tatgtgtggc taccgcgggt atgcgagtgc   3420

cagatattgg ctgagacgag ccagcttaga ctaattggta caaggaaggc aagaaaacaa   3480

agacaaataa acagcggaag ttatcagtat ggaggggaag tgtaaactta aagggaccag   3540

actttctaaa tcttacaact caagaggtgg cagccaccct ctaggagaca aaactacccc   3600

cactgacaag gctttaggag accctaaagt ctgttggctg tgacgtcatt atacctaaaa   3660

tctgcatcat acctgcaagc caacagttca gtgttttaac agagaaccac cctgggaaac   3720

agaagcagat ctgatgtgtt tcctatacat gtcctgtgct cactttatta aaaattcttt   3780

tgcacacaat gtttatgaaa aggccagatc cttttccaat acttatgcaa aagcaaaaga   3840

aaaccccgac acctcacctt tcgctgtttg ttgtttcata gatttattta aaaaaagaga   3900

aagtctatag ctataaatct ttaaagagaa atatgaatac aattccccta aactctcctc   3960

aaaagagaat tcagtctaca gccatttaaa tgatcattgc tgctacagaa gtgctttaag   4020

agaattgcct gaaacatctg tattatatcg gccacctgcc aatcacagct ttactctttc   4080

aggtcactct ggggctgcct cttgcatgta ttactaaata aaatgatctc tctttctctc   4140

tctctctctc ttttctaaga aacaattatg tgcactttga tacacaacct tctctaacca   4200

actatatatc aagacccaaa aattgaagaa aaatattgtt ttctcataca gtgagcagat   4260

ttttcaatct actaattctg tgacttgtct tggtgtgcta gcctacacct tctctttggt   4320

ttagttttcc ttttctataa cactctgaat tgctaatctt actaacacct atgatgttac   4380

ctgaaatcaa tctcccatat gtatgctgta tgctatgcta agactcctga aatatactta   4440

ctctgtgctt gtgtatgtga atgttaatgc aactattacc tagagtgaac tttaagcttt   4500

attgttgaat gtaattccat tatatttcct tttgtacacc tgtgaaaaag tggagtagtg   4560

tttttttaac cattgttaat cagcttttgt gtatgaaaga cacagtaaaa tttctttctt   4620

aaatcaagat actggtgatt caaggaattt tatttatggt ccagccaaga gccatctcgt   4680

gccaagactt ctgctggcaa gggaatggat aaagctgttt tgttctagta acaattttgg   4740

aatgaatact gacaatattc catgagggtg tgcaagcaca aattttacca atctgacctc   4800

tttgaagttg cagaatgctt tgaaattcta atggtatctg aaatatcagc tcatagaaag   4860

taacaaaatt tgctgtcacc ttaaataaga cattttaatt ttgttataat gtacaattta   4920

gaagtttgat taattatatt atctatttag gcattaatat aaaagaggta ggagtctgtt   4980

atttaaaaaa agcattaaat ttaaaaaaaa actgtcttgt ctacttttag cttcattctc   5040

ccatattttg aagggtgtgt aacttcagct ctgcaggatt gcatggggta aaacttgtta   5100

ccaacacatg tgaaccattg ctacattgta ggttgtgatc attttgcccc actgaagccc   5160

atgtatctga ccttacgtgc cttttgaact aggagaatcg ggctaattta ttaatgatga   5220

taattataat gtatctgtac agcacttttt acatttgcga agtgctttcc aatccatgtt   5280

agttactagt tattacagct gtaaggataa aacacgtcat gtggattcat tttgaattgg   5340

tgctattggt atttcctctg ttattgctaa taaatgaaaa tggtggtatg aaa          5393


<210>  2165
<211>  936
<212>  PRT
<213>  Homo sapiens

<400>  2165


Met Val Tyr Ser Arg Arg Gly Ser Leu Gly Ser Arg Leu Leu Leu Leu 
1               5                   10                  15      


Trp Leu Leu Leu Ala Tyr Trp Lys Ala Gly Ser Gly Gln Leu His Tyr 
            20                  25                  30          


Ser Ile Pro Glu Glu Ala Lys His Gly Thr Phe Val Gly Arg Ile Ala 
        35                  40                  45              


Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Pro Arg Leu Phe Arg 
    50                  55                  60                  


Val Ala Ser Lys Gly Arg Gly Asp Leu Leu Glu Val Asn Leu Gln Asn 
65                  70                  75                  80  


Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys Arg 
                85                  90                  95      


Arg Arg Ala Glu Cys Ser Ile His Leu Glu Val Ile Val Asp Arg Pro 
            100                 105                 110         


Leu Gln Val Phe His Val Glu Val Ala Val Lys Asp Ile Asn Asp Asn 
        115                 120                 125             


Pro Pro Arg Phe Ser Arg Gln Glu Gln Arg Leu Phe Ile Leu Glu Ser 
    130                 135                 140                 


Arg Met Pro Asp Ser Arg Phe Pro Leu Glu Gly Ala Ser Asp Leu Asp 
145                 150                 155                 160 


Ile Gly Ala Asn Ala Gln Leu Arg Tyr Arg Leu Asn Pro Asn Glu Tyr 
                165                 170                 175     


Phe Asp Leu Asp Val Lys Thr Asn Glu Glu Glu Thr Asn Phe Leu Glu 
            180                 185                 190         


Leu Val Leu Arg Lys Ser Leu Asp Arg Glu Glu Thr Gln Glu His Arg 
        195                 200                 205             


Leu Leu Val Ile Ala Thr Asp Gly Gly Lys Pro Glu Leu Thr Gly Thr 
    210                 215                 220                 


Val Gln Leu Leu Ile Asn Val Leu Asp Ala Asn Asp Asn Ala Pro Glu 
225                 230                 235                 240 


Phe Asp Lys Ser Ile Tyr Asn Val Arg Leu Leu Glu Asn Ala Pro Ser 
                245                 250                 255     


Gly Thr Leu Val Ile Lys Leu Asn Ala Ser Asp Ala Asp Glu Gly Ile 
            260                 265                 270         


Asn Lys Glu Ile Val Tyr Phe Phe Ser Asn Leu Val Leu Asp Asp Val 
        275                 280                 285             


Lys Ser Lys Phe Ile Ile Asn Ser Asn Thr Gly Glu Ile Lys Val Asn 
    290                 295                 300                 


Gly Glu Leu Asp Tyr Glu Asp Tyr Asn Ser Tyr Glu Ile Asn Ile Asp 
305                 310                 315                 320 


Ala Met Asp Lys Ser Thr Phe Pro Leu Ser Gly His Cys Lys Val Val 
                325                 330                 335     


Val Lys Leu Leu Asp Val Asn Asp Asn Thr Pro Glu Met Ala Ile Thr 
            340                 345                 350         


Thr Leu Phe Leu Pro Val Lys Glu Asp Ala Pro Leu Ser Thr Val Ile 
        355                 360                 365             


Ala Leu Ile Ser Val Ser Asp Arg Asp Ser Gly Ala Asn Gly Gln Val 
    370                 375                 380                 


Thr Cys Ser Leu Met Pro His Val Pro Phe Lys Leu Val Ser Thr Phe 
385                 390                 395                 400 


Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu Ser 
                405                 410                 415     


Val Ser Val Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser Pro 
            420                 425                 430         


Ser Leu Trp Ala Thr Ala Ser Val Ser Val Glu Val Ala Asp Val Asn 
        435                 440                 445             


Asp Asn Ala Pro Ala Phe Ala Gln Pro Gln Tyr Thr Val Phe Val Lys 
    450                 455                 460                 


Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Arg Asp 
465                 470                 475                 480 


Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu Arg 
                485                 490                 495     


Arg Val Gly Glu Arg Pro Leu Ser Ser Tyr Val Ser Val His Ala Glu 
            500                 505                 510         


Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Val Glu 
        515                 520                 525             


Leu Leu Gln Phe Gln Val Ser Ala Arg Asp Ala Gly Val Pro Pro Leu 
    530                 535                 540                 


Gly Ser Asn Val Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp Asn 
545                 550                 555                 560 


Ala Pro Ala Leu Leu Val Pro Arg Val Gly Gly Thr Gly Gly Ala Val 
                565                 570                 575     


Ser Glu Leu Val Pro Arg Ser Val Gly Ala Gly His Val Val Ala Lys 
            580                 585                 590         


Val Arg Ala Val Asp Pro Asp Ser Gly Tyr Asn Ala Trp Leu Ser Tyr 
        595                 600                 605             


Glu Leu Gln Pro Ala Pro Gly Ser Ala Arg Ile Pro Phe Arg Val Gly 
    610                 615                 620                 


Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Ser Leu Asp Glu Thr Glu 
625                 630                 635                 640 


Ala Pro Arg His Arg Leu Leu Val Leu Val Lys Asp His Gly Glu Pro 
                645                 650                 655     


Pro Leu Thr Ala Thr Ala Thr Val Leu Val Ser Leu Val Glu Ser Gly 
            660                 665                 670         


Gln Ala Pro Lys Ala Ser Ser Arg Ala Ser Ala Gly Ala Val Gly Pro 
        675                 680                 685             


Glu Ala Ala Leu Val Asp Val Asn Val Tyr Leu Ile Ile Ala Ile Cys 
    690                 695                 700                 


Ala Val Ser Ser Leu Leu Val Leu Thr Leu Leu Leu Tyr Thr Ala Leu 
705                 710                 715                 720 


Arg Cys Ser Ala Gln Pro Thr Glu Ala Val Cys Thr Arg Gly Lys Pro 
                725                 730                 735     


Thr Leu Leu Cys Ser Ser Ala Val Gly Ser Trp Ser Tyr Ser Gln Gln 
            740                 745                 750         


Arg Arg Gln Arg Val Cys Ser Gly Glu Ala Pro Pro Lys Thr Asp Leu 
        755                 760                 765             


Met Ala Phe Ser Pro Ser Leu Pro Gln Gly Pro Thr Ser Thr Asp Asn 
    770                 775                 780                 


Pro Arg Gln Pro Asn Pro Asp Trp Arg Tyr Ser Ala Ser Leu Arg Ala 
785                 790                 795                 800 


Gly Met His Ser Ser Val His Leu Glu Glu Ala Gly Ile Leu Arg Ala 
                805                 810                 815     


Gly Pro Gly Gly Pro Asp Gln Gln Trp Pro Thr Val Ser Ser Ala Thr 
            820                 825                 830         


Pro Glu Pro Glu Ala Gly Glu Val Ser Pro Pro Val Gly Ala Gly Val 
        835                 840                 845             


Asn Ser Asn Ser Trp Thr Phe Lys Tyr Gly Pro Gly Asn Pro Lys Gln 
    850                 855                 860                 


Ser Gly Pro Gly Glu Leu Pro Asp Lys Phe Ile Ile Pro Gly Ser Pro 
865                 870                 875                 880 


Ala Ile Ile Ser Ile Arg Gln Glu Pro Thr Asn Ser Gln Ile Asp Lys 
                885                 890                 895     


Ser Asp Phe Ile Thr Phe Gly Lys Lys Glu Glu Thr Lys Lys Lys Lys 
            900                 905                 910         


Lys Lys Lys Lys Gly Asn Lys Thr Gln Glu Lys Lys Glu Lys Gly Asn 
        915                 920                 925             


Ser Thr Thr Asp Asn Ser Asp Gln 
    930                 935     

<210>  2166
<211>  2400
<212>  DNA
<213>  Homo sapiens

<400>  2166
ctgtgggtcc cgaggctgcc ctggtggatg tcaacgtgta cctgatcatc gccatctgtg     60

cggtgtccag cctgctggtg ctcacgctgc tgctgtacac cgcgctgcgg tgctcggcgc    120

agcccaccga ggccgtgtgc acacggggca agcccactct gttgtgctcc agcgcggtgg    180

ggagctggtc gtactcgcag cagaggagac agagggtgtg ctctggggaa gctccaccca    240

aaacagacct catggccttc agtccaagcc ttcctcaggg tcccacctct acagacaacc    300

cacgacagcc caaccctgac tggcgttact ctgcctccct gagagcaggc atgcacagct    360

ctgtgcacct agaggaggct ggcattctac gggctggtcc aggagggcct gatcagcagt    420

ggccaacagt atccagtgca acaccagaac cagaggcagg agaagtgtcc cctccagtcg    480

gtgcgggtgt caacagcaac agctggacct ttaaatacgg accaggcaac cccaaacaat    540

ccggtcccgg tgagttgccc gacaaattca ttatcccagg atctcctgca atcatctcca    600

tccggcagga gcctactaac agccaaattg acaaaagtga cttcataacc ttcggcaaaa    660

aggaggagac caagaaaaag aagaaaaaga agaagggtaa caagacccag gagaaaaaag    720

agaaagggaa cagcacgact gacaacagtg accagtgagg tcctcaaatg gaaacaagcc    780

acttagccag tttttgtaat aatggcaaat ctctcccatg tagcaattcc ctgctccttt    840

ttcctatcta catgagccct cttagagacc tcagaaatct gcagaaagtt ccctgtgtct    900

gtctagaacg catttaacag gttttgtcgt aaaagcttta ctaagtctgg tgttaactct    960

ttctctccac tctggcttgt tttcagaacc taaaaagcag acccaagttt cctttctcct   1020

ccgccgcaaa ggagaggctt cccagccccg ccagtgagag gttggactct ctgccctgtg   1080

ctccggggat cctgtcttga tgacacttgc agggcaggct gaaaagtttt gagattgagc   1140

agcttgggag tttgtggcca ctgggtatgt gtggctaccg cgggtatgcg agtgccagat   1200

attggctgag acgagccagc ttagactaat tggtacaagg aaggcaagaa aacaaagaca   1260

aataaacagc ggaagttatc agtatggagg ggaagtgtaa acttaaaggg accagacttt   1320

ctaaatctta caactcaaga ggtggcagcc accctctagg agacaaaact acccccactg   1380

acaaggcttt aggagaccct aaagtctgtt ggctgtgacg tcattatacc taaaatctgc   1440

atcatacctg caagccaaca gttcagtgtt ttaacagaga accaccctgg gaaacagaag   1500

cagatctgat gtgtttccta tacatgtcct gtgctcactt tattaaaaat tcttttgcac   1560

acaatgttta tgaaaaggcc agatcctttt ccaatactta tgcaaaagca aaagaaaacc   1620

ccgacacctc acctttcgct gtttgttgtt tcatagattt atttaaaaaa agagaaagtc   1680

tatagctata aatctttaaa gagaaatatg aatacaattc ccctaaactc tcctcaaaag   1740

agaattcagt ctacagccat ttaaatgatc attgctgcta cagaagtgct ttaagagaat   1800

tgcctgaaac atctgtatta tatcggccac ctgccaatca cagctttact ctttcaggtc   1860

actctggggc tgcctcttgc atgtattact aaataaaatg atctctcttt ctctctctct   1920

ctctcttttc taagaaacaa ttatgtgcac tttgatacac aaccttctct aaccaactat   1980

atatcaagac ccaaaaattg aagaaaaata ttgttttctc atacagtgag cagatttttc   2040

aatctactaa ttctgtgact tgtcttggtg tgctagccta caccttctct ttggtttagt   2100

tttccttttc tataacactc tgaattgcta atcttactaa cacctatgat gttacctgaa   2160

atcaatctcc catatgtatg ctgtatgcta tgctaagact cctgaaatat acttactctg   2220

tgcttgtgta tgtgaatgtt aatgcaacta ttacctagag tgaactttaa gctttattgt   2280

tgaatgtaat tccattatat ttccttttgt acacctgtga aaaagtggag tagtgttttt   2340

ttaaccattg ttaatcagct tttgtgtatg aaagacacag taaaatttct ttcttaaatc   2400


<210>  2167
<211>  168
<212>  PRT
<213>  Homo sapiens

<400>  2167


Met Ala Phe Ser Pro Ser Leu Pro Gln Gly Pro Thr Ser Thr Asp Asn 
1               5                   10                  15      


Pro Arg Gln Pro Asn Pro Asp Trp Arg Tyr Ser Ala Ser Leu Arg Ala 
            20                  25                  30          


Gly Met His Ser Ser Val His Leu Glu Glu Ala Gly Ile Leu Arg Ala 
        35                  40                  45              


Gly Pro Gly Gly Pro Asp Gln Gln Trp Pro Thr Val Ser Ser Ala Thr 
    50                  55                  60                  


Pro Glu Pro Glu Ala Gly Glu Val Ser Pro Pro Val Gly Ala Gly Val 
65                  70                  75                  80  


Asn Ser Asn Ser Trp Thr Phe Lys Tyr Gly Pro Gly Asn Pro Lys Gln 
                85                  90                  95      


Ser Gly Pro Gly Glu Leu Pro Asp Lys Phe Ile Ile Pro Gly Ser Pro 
            100                 105                 110         


Ala Ile Ile Ser Ile Arg Gln Glu Pro Thr Asn Ser Gln Ile Asp Lys 
        115                 120                 125             


Ser Asp Phe Ile Thr Phe Gly Lys Lys Glu Glu Thr Lys Lys Lys Lys 
    130                 135                 140                 


Lys Lys Lys Lys Gly Asn Lys Thr Gln Glu Lys Lys Glu Lys Gly Asn 
145                 150                 155                 160 


Ser Thr Thr Asp Asn Ser Asp Gln 
                165             

<210>  2168
<211>  3873
<212>  DNA
<213>  Homo sapiens

<400>  2168
ccatgaagtt atagctagcc aacattcaaa tttcttctat tactgcatca ttccctgact     60

gttgaatgat ggcggacgca gaagaaatgg attaataaat tccggaacat acagtatttt    120

atctttatgc ggaagatctt ctaatggaaa taaaaccaga ggtatttgac atggtgttta    180

ccccggagga tagattggga aagcaatgtc tgctcctccc gcttctgctc ctcgcagcct    240

ggaaggtggg gagcggccag ctccactact ccgtacccga ggaggccaaa cacggcacct    300

tcgtgggccg gatcgcgcag gacctggggc tggagctggc ggagctggtg ccgcgcctgt    360

tcaggatggc ctccaaagac cgcgaggacc ttctggaggt aaatctgcag aatggcattt    420

tgtttgtgaa ttctcggatc gaccgcgagg agctgtgcgg gcggagcgcg gagtgcagca    480

tccacctgga ggtgatcgtg gacaggccgc tgcaggtttt ccatgtggac gtggaggtga    540

gggacattaa cgacaacccg cccttgttcc cggtagagga acaaagagtg ctgatttacg    600

aatctaggct gccagattct gtgtttccac tggagggcgc gtccgatgca gatgttggct    660

caaattccat cttaacctat aaactcagtt ctagcgaata cttcgggcta gatgtgaaaa    720

taaacagtga tgacaataaa caaattgggc tcttattaaa gaaatccttg gacagagagg    780

aagctcctgc acacaactta ttcctgacag ccacagatgg gggcaaacct gagctcacag    840

gcactgttca gctgctggtc acagtgctgg atgtgaatga taatgctccc actttcgaac    900

agtctgaata cgaagtaaga atattcgaaa atgcagacaa cggaacaaca gttatcagac    960

tgaatgcttc tgatcgggat gaaggagcga atggggcaat ttcatattct tttaatagcc   1020

ttgttgcagc catggttatt gaccacttta gcatagatcg aaatacggga gaaatagtga   1080

ttcggggtaa tttggatttt gaacaagaaa acttatacaa aatcctcatt gacgccacgg   1140

acaaaggcca tcctcccatg gcgggtcatt gcaccgtttt agtgagaatt ttggataaaa   1200

atgataacgt ccctgagata gcactgactt ccttatcctt gcctgtacgt gaagacgctc   1260

aatttggtac tgtcatcgcc ctaattagcg tgaacgacct cgattcaggt gccaacgggc   1320

aggtgaactg ctcgctgacg cctcacgtcc ctttcaagct ggtgtccacc ttcaagaatt   1380

actactcgtt ggtgctggac agtgccctgg accgcgagag cgtgtcggcc tatgagttgg   1440

tggtaaccgc gcgggacggg ggctcgcctt cgctgtgggc caccgccagc ttgtctgtgg   1500

aggtggccga catgaatgac aatgctccgg cgttcgcgca gcccgagtac acagtgttcg   1560

tgaaggagaa caacccgccg ggctgccaca tcttcacggt gtctgcgcga gacgcggacg   1620

cgcaggagaa cgcgctggtg tcctactcgc tggtggagcg gcgggtgggc gagcgcgcgt   1680

tgtcgagcta catttcggtg cacgcggaga gcggcaaggt gtacgcgctg cagccgctgg   1740

accacgagga gctagagctg ctgcagtttc agccacgaca gcccaaccct gactggcgtt   1800

actctgcctc cctgagagca ggcatgcaca gctctgtgca cctagaggag gctggcattc   1860

tacgggctgg tccaggaggg cctgatcagc agtggccaac agtatccagt gcaacaccag   1920

aaccagaggc aggagaagtg tcccctccag tcggtgcggg tgtcaacagc aacagctgga   1980

cctttaaata cggaccaggc aaccccaaac aatccggtcc cggtgagttg cccgacaaat   2040

tcattatccc aggatctcct gcaatcatct ccatccggca ggagcctact aacagccaaa   2100

ttgacaaaag tgacttcata accttcggca aaaaggagga gaccaagaaa aagaagaaaa   2160

agaagaaggg taacaagacc caggagaaaa aagagaaagg gaacagcacg actgacaaca   2220

gtgaccagtg aggtcctcaa atggaaacaa gccacttagc cagtttttgt aataatggca   2280

aatctctccc atgtagcaat tccctgctcc tttttcctat ctacatgagc cctcttagag   2340

acctcagaaa tctgcagaaa gttccctgtg tctgtctaga acgcatttaa caggttttgt   2400

cgtaaaagct ttactaagtc tggtgttaac tctttctctc cactctggct tgttttcaga   2460

acctaaaaag cagacccaag tttcctttct cctccgccgc aaaggagagg cttcccagcc   2520

ccgccagtga gaggttggac tctctgccct gtgctccggg gatcctgtct tgatgacact   2580

tgcagggcag gctgaaaagt tttgagattg agcagcttgg gagtttgtgg ccactgggta   2640

tgtgtggcta ccgcgggtat gcgagtgcca gatattggct gagacgagcc agcttagact   2700

aattggtaca aggaaggcaa gaaaacaaag acaaataaac agcggaagtt atcagtatgg   2760

aggggaagtg taaacttaaa gggaccagac tttctaaatc ttacaactca agaggtggca   2820

gccaccctct aggagacaaa actaccccca ctgacaaggc tttaggagac cctaaagtct   2880

gttggctgtg acgtcattat acctaaaatc tgcatcatac ctgcaagcca acagttcagt   2940

gttttaacag agaaccaccc tgggaaacag aagcagatct gatgtgtttc ctatacatgt   3000

cctgtgctca ctttattaaa aattcttttg cacacaatgt ttatgaaaag gccagatcct   3060

tttccaatac ttatgcaaaa gcaaaagaaa accccgacac ctcacctttc gctgtttgtt   3120

gtttcataga tttatttaaa aaaagagaaa gtctatagct ataaatcttt aaagagaaat   3180

atgaatacaa ttcccctaaa ctctcctcaa aagagaattc agtctacagc catttaaatg   3240

atcattgctg ctacagaagt gctttaagag aattgcctga aacatctgta ttatatcggc   3300

cacctgccaa tcacagcttt actctttcag gtcactctgg ggctgcctct tgcatgtatt   3360

actaaataaa atgatctctc tttctctctc tctctctctt ttctaagaaa caattatgtg   3420

cactttgata cacaaccttc tctaaccaac tatatatcaa gacccaaaaa ttgaagaaaa   3480

atattgtttt ctcatacagt gagcagattt ttcaatctac taattctgtg acttgtcttg   3540

gtgtgctagc ctacaccttc tctttggttt agttttcctt ttctataaca ctctgaattg   3600

ctaatcttac taacacctat gatgttacct gaaatcaatc tcccatatgt atgctgtatg   3660

ctatgctaag actcctgaaa tatacttact ctgtgcttgt gtatgtgaat gttaatgcaa   3720

ctattaccta gagtgaactt taagctttat tgttgaatgt aattccatta tatttccttt   3780

tgtacacctg tgaaaaagtg gagtagtgtt tttttaacca ttgttaatca gcttttgtgt   3840

atgaaagaca cagtaaaatt tctttcttaa atc                                3873


<210>  2169
<211>  695
<212>  PRT
<213>  Homo sapiens

<400>  2169


Met Glu Ile Lys Pro Glu Val Phe Asp Met Val Phe Thr Pro Glu Asp 
1               5                   10                  15      


Arg Leu Gly Lys Gln Cys Leu Leu Leu Pro Leu Leu Leu Leu Ala Ala 
            20                  25                  30          


Trp Lys Val Gly Ser Gly Gln Leu His Tyr Ser Val Pro Glu Glu Ala 
        35                  40                  45              


Lys His Gly Thr Phe Val Gly Arg Ile Ala Gln Asp Leu Gly Leu Glu 
    50                  55                  60                  


Leu Ala Glu Leu Val Pro Arg Leu Phe Arg Met Ala Ser Lys Asp Arg 
65                  70                  75                  80  


Glu Asp Leu Leu Glu Val Asn Leu Gln Asn Gly Ile Leu Phe Val Asn 
                85                  90                  95      


Ser Arg Ile Asp Arg Glu Glu Leu Cys Gly Arg Ser Ala Glu Cys Ser 
            100                 105                 110         


Ile His Leu Glu Val Ile Val Asp Arg Pro Leu Gln Val Phe His Val 
        115                 120                 125             


Asp Val Glu Val Arg Asp Ile Asn Asp Asn Pro Pro Leu Phe Pro Val 
    130                 135                 140                 


Glu Glu Gln Arg Val Leu Ile Tyr Glu Ser Arg Leu Pro Asp Ser Val 
145                 150                 155                 160 


Phe Pro Leu Glu Gly Ala Ser Asp Ala Asp Val Gly Ser Asn Ser Ile 
                165                 170                 175     


Leu Thr Tyr Lys Leu Ser Ser Ser Glu Tyr Phe Gly Leu Asp Val Lys 
            180                 185                 190         


Ile Asn Ser Asp Asp Asn Lys Gln Ile Gly Leu Leu Leu Lys Lys Ser 
        195                 200                 205             


Leu Asp Arg Glu Glu Ala Pro Ala His Asn Leu Phe Leu Thr Ala Thr 
    210                 215                 220                 


Asp Gly Gly Lys Pro Glu Leu Thr Gly Thr Val Gln Leu Leu Val Thr 
225                 230                 235                 240 


Val Leu Asp Val Asn Asp Asn Ala Pro Thr Phe Glu Gln Ser Glu Tyr 
                245                 250                 255     


Glu Val Arg Ile Phe Glu Asn Ala Asp Asn Gly Thr Thr Val Ile Arg 
            260                 265                 270         


Leu Asn Ala Ser Asp Arg Asp Glu Gly Ala Asn Gly Ala Ile Ser Tyr 
        275                 280                 285             


Ser Phe Asn Ser Leu Val Ala Ala Met Val Ile Asp His Phe Ser Ile 
    290                 295                 300                 


Asp Arg Asn Thr Gly Glu Ile Val Ile Arg Gly Asn Leu Asp Phe Glu 
305                 310                 315                 320 


Gln Glu Asn Leu Tyr Lys Ile Leu Ile Asp Ala Thr Asp Lys Gly His 
                325                 330                 335     


Pro Pro Met Ala Gly His Cys Thr Val Leu Val Arg Ile Leu Asp Lys 
            340                 345                 350         


Asn Asp Asn Val Pro Glu Ile Ala Leu Thr Ser Leu Ser Leu Pro Val 
        355                 360                 365             


Arg Glu Asp Ala Gln Phe Gly Thr Val Ile Ala Leu Ile Ser Val Asn 
    370                 375                 380                 


Asp Leu Asp Ser Gly Ala Asn Gly Gln Val Asn Cys Ser Leu Thr Pro 
385                 390                 395                 400 


His Val Pro Phe Lys Leu Val Ser Thr Phe Lys Asn Tyr Tyr Ser Leu 
                405                 410                 415     


Val Leu Asp Ser Ala Leu Asp Arg Glu Ser Val Ser Ala Tyr Glu Leu 
            420                 425                 430         


Val Val Thr Ala Arg Asp Gly Gly Ser Pro Ser Leu Trp Ala Thr Ala 
        435                 440                 445             


Ser Leu Ser Val Glu Val Ala Asp Met Asn Asp Asn Ala Pro Ala Phe 
    450                 455                 460                 


Ala Gln Pro Glu Tyr Thr Val Phe Val Lys Glu Asn Asn Pro Pro Gly 
465                 470                 475                 480 


Cys His Ile Phe Thr Val Ser Ala Arg Asp Ala Asp Ala Gln Glu Asn 
                485                 490                 495     


Ala Leu Val Ser Tyr Ser Leu Val Glu Arg Arg Val Gly Glu Arg Ala 
            500                 505                 510         


Leu Ser Ser Tyr Ile Ser Val His Ala Glu Ser Gly Lys Val Tyr Ala 
        515                 520                 525             


Leu Gln Pro Leu Asp His Glu Glu Leu Glu Leu Leu Gln Phe Gln Pro 
    530                 535                 540                 


Arg Gln Pro Asn Pro Asp Trp Arg Tyr Ser Ala Ser Leu Arg Ala Gly 
545                 550                 555                 560 


Met His Ser Ser Val His Leu Glu Glu Ala Gly Ile Leu Arg Ala Gly 
                565                 570                 575     


Pro Gly Gly Pro Asp Gln Gln Trp Pro Thr Val Ser Ser Ala Thr Pro 
            580                 585                 590         


Glu Pro Glu Ala Gly Glu Val Ser Pro Pro Val Gly Ala Gly Val Asn 
        595                 600                 605             


Ser Asn Ser Trp Thr Phe Lys Tyr Gly Pro Gly Asn Pro Lys Gln Ser 
    610                 615                 620                 


Gly Pro Gly Glu Leu Pro Asp Lys Phe Ile Ile Pro Gly Ser Pro Ala 
625                 630                 635                 640 


Ile Ile Ser Ile Arg Gln Glu Pro Thr Asn Ser Gln Ile Asp Lys Ser 
                645                 650                 655     


Asp Phe Ile Thr Phe Gly Lys Lys Glu Glu Thr Lys Lys Lys Lys Lys 
            660                 665                 670         


Lys Lys Lys Gly Asn Lys Thr Gln Glu Lys Lys Glu Lys Gly Asn Ser 
        675                 680                 685             


Thr Thr Asp Asn Ser Asp Gln 
    690                 695 

<210>  2170
<211>  4665
<212>  DNA
<213>  Homo sapiens

<400>  2170
ccatgaagtt atagctagcc aacattcaaa tttcttctat tactgcatca ttccctgact     60

gttgaatgat ggcggacgca gaagaaatgg attaataaat tccggaacat acagtatttt    120

atctttatgc ggaagatctt ctaatggaaa taaaaccaga ggtatttgac atggtgttta    180

ccccggagga tagattggga aagcaatgtc tgctcctccc gcttctgctc ctcgcagcct    240

ggaaggtggg gagcggccag ctccactact ccgtacccga ggaggccaaa cacggcacct    300

tcgtgggccg gatcgcgcag gacctggggc tggagctggc ggagctggtg ccgcgcctgt    360

tcaggatggc ctccaaagac cgcgaggacc ttctggaggt aaatctgcag aatggcattt    420

tgtttgtgaa ttctcggatc gaccgcgagg agctgtgcgg gcggagcgcg gagtgcagca    480

tccacctgga ggtgatcgtg gacaggccgc tgcaggtttt ccatgtggac gtggaggtga    540

gggacattaa cgacaacccg cccttgttcc cggtagagga acaaagagtg ctgatttacg    600

aatctaggct gccagattct gtgtttccac tggagggcgc gtccgatgca gatgttggct    660

caaattccat cttaacctat aaactcagtt ctagcgaata cttcgggcta gatgtgaaaa    720

taaacagtga tgacaataaa caaattgggc tcttattaaa gaaatccttg gacagagagg    780

aagctcctgc acacaactta ttcctgacag ccacagatgg gggcaaacct gagctcacag    840

gcactgttca gctgctggtc acagtgctgg atgtgaatga taatgctccc actttcgaac    900

agtctgaata cgaagtaaga atattcgaaa atgcagacaa cggaacaaca gttatcagac    960

tgaatgcttc tgatcgggat gaaggagcga atggggcaat ttcatattct tttaatagcc   1020

ttgttgcagc catggttatt gaccacttta gcatagatcg aaatacggga gaaatagtga   1080

ttcggggtaa tttggatttt gaacaagaaa acttatacaa aatcctcatt gacgccacgg   1140

acaaaggcca tcctcccatg gcgggtcatt gcaccgtttt agtgagaatt ttggataaaa   1200

atgataacgt ccctgagata gcactgactt ccttatcctt gcctgtacgt gaagacgctc   1260

aatttggtac tgtcatcgcc ctaattagcg tgaacgacct cgattcaggt gccaacgggc   1320

aggtgaactg ctcgctgacg cctcacgtcc ctttcaagct ggtgtccacc ttcaagaatt   1380

actactcgtt ggtgctggac agtgccctgg accgcgagag cgtgtcggcc tatgagttgg   1440

tggtaaccgc gcgggacggg ggctcgcctt cgctgtgggc caccgccagc ttgtctgtgg   1500

aggtggccga catgaatgac aatgctccgg cgttcgcgca gcccgagtac acagtgttcg   1560

tgaaggagaa caacccgccg ggctgccaca tcttcacggt gtctgcgcga gacgcggacg   1620

cgcaggagaa cgcgctggtg tcctactcgc tggtggagcg gcgggtgggc gagcgcgcgt   1680

tgtcgagcta catttcggtg cacgcggaga gcggcaaggt gtacgcgctg cagccgctgg   1740

accacgagga gctagagctg ctgcagtttc aggtgagcgc gcgcgacgcg ggcgtgccgc   1800

ctctgggcag caacgtgacg ctgcaggtgt tcgtgctgga cgagaacgac aacgcgccgg   1860

cgctgctggc gcctcgggtg ggtggtactg gtggtgcagt gagcgagctg gtgccgcggt   1920

cactgggtgc aggccaagtg gtggcgaagg tgcgcgcagt tgacgccgac tcaggctaca   1980

acgcgtggct ttcgtatgag ctgcagcccc cggcaagcag cgctcgcttc ccgtttcgcg   2040

tggggctgta cacgggcgag atcagcacca ctcgtgtcct ggacgaagcg gactctccgc   2100

gccaccggct gctggtgctg gtgaaagacc acggtgagcc ggcgctgaca gcgacggcca   2160

cggttctggt gtcgctggtg gagagtggcc aggctccaaa ggcgtcatca cgggcgtcgg   2220

tgggcgccgc gggcccagag gcggcgctgg tggatgtcaa cgtgtacctg atcatcgcca   2280

tctgcgcggt atccagcctg ctggtcctca cgctactgct gtacacagcg ctgcggtgct   2340

cggcgccacc caccgagggc gcgtgcacgg cggacaagcc cacgctggtg tgctccagcg   2400

cagtggggag ctggtcgtac tcgcagcaga ggcggcagag ggtgtgctcc ggggagggcc   2460

cacccaagat ggatctcatg gcctttagcc ccagcctttc accttgtcct attatgatgg   2520

gtaaggcgga gaatcaggat ttaaatgaag atcatgatgc caaaccacga cagcccaacc   2580

ctgactggcg ttactctgcc tccctgagag caggcatgca cagctctgtg cacctagagg   2640

aggctggcat tctacgggct ggtccaggag ggcctgatca gcagtggcca acagtatcca   2700

gtgcaacacc agaaccagag gcaggagaag tgtcccctcc agtcggtgcg ggtgtcaaca   2760

gcaacagctg gacctttaaa tacggaccag gcaaccccaa acaatccggt cccggtgagt   2820

tgcccgacaa attcattatc ccaggatctc ctgcaatcat ctccatccgg caggagccta   2880

ctaacagcca aattgacaaa agtgacttca taaccttcgg caaaaaggag gagaccaaga   2940

aaaagaagaa aaagaagaag ggtaacaaga cccaggagaa aaaagagaaa gggaacagca   3000

cgactgacaa cagtgaccag tgaggtcctc aaatggaaac aagccactta gccagttttt   3060

gtaataatgg caaatctctc ccatgtagca attccctgct cctttttcct atctacatga   3120

gccctcttag agacctcaga aatctgcaga aagttccctg tgtctgtcta gaacgcattt   3180

aacaggtttt gtcgtaaaag ctttactaag tctggtgtta actctttctc tccactctgg   3240

cttgttttca gaacctaaaa agcagaccca agtttccttt ctcctccgcc gcaaaggaga   3300

ggcttcccag ccccgccagt gagaggttgg actctctgcc ctgtgctccg gggatcctgt   3360

cttgatgaca cttgcagggc aggctgaaaa gttttgagat tgagcagctt gggagtttgt   3420

ggccactggg tatgtgtggc taccgcgggt atgcgagtgc cagatattgg ctgagacgag   3480

ccagcttaga ctaattggta caaggaaggc aagaaaacaa agacaaataa acagcggaag   3540

ttatcagtat ggaggggaag tgtaaactta aagggaccag actttctaaa tcttacaact   3600

caagaggtgg cagccaccct ctaggagaca aaactacccc cactgacaag gctttaggag   3660

accctaaagt ctgttggctg tgacgtcatt atacctaaaa tctgcatcat acctgcaagc   3720

caacagttca gtgttttaac agagaaccac cctgggaaac agaagcagat ctgatgtgtt   3780

tcctatacat gtcctgtgct cactttatta aaaattcttt tgcacacaat gtttatgaaa   3840

aggccagatc cttttccaat acttatgcaa aagcaaaaga aaaccccgac acctcacctt   3900

tcgctgtttg ttgtttcata gatttattta aaaaaagaga aagtctatag ctataaatct   3960

ttaaagagaa atatgaatac aattccccta aactctcctc aaaagagaat tcagtctaca   4020

gccatttaaa tgatcattgc tgctacagaa gtgctttaag agaattgcct gaaacatctg   4080

tattatatcg gccacctgcc aatcacagct ttactctttc aggtcactct ggggctgcct   4140

cttgcatgta ttactaaata aaatgatctc tctttctctc tctctctctc ttttctaaga   4200

aacaattatg tgcactttga tacacaacct tctctaacca actatatatc aagacccaaa   4260

aattgaagaa aaatattgtt ttctcataca gtgagcagat ttttcaatct actaattctg   4320

tgacttgtct tggtgtgcta gcctacacct tctctttggt ttagttttcc ttttctataa   4380

cactctgaat tgctaatctt actaacacct atgatgttac ctgaaatcaa tctcccatat   4440

gtatgctgta tgctatgcta agactcctga aatatactta ctctgtgctt gtgtatgtga   4500

atgttaatgc aactattacc tagagtgaac tttaagcttt attgttgaat gtaattccat   4560

tatatttcct tttgtacacc tgtgaaaaag tggagtagtg tttttttaac cattgttaat   4620

cagcttttgt gtatgaaaga cacagtaaaa tttctttctt aaatc                   4665


<210>  2171
<211>  959
<212>  PRT
<213>  Homo sapiens

<400>  2171


Met Glu Ile Lys Pro Glu Val Phe Asp Met Val Phe Thr Pro Glu Asp 
1               5                   10                  15      


Arg Leu Gly Lys Gln Cys Leu Leu Leu Pro Leu Leu Leu Leu Ala Ala 
            20                  25                  30          


Trp Lys Val Gly Ser Gly Gln Leu His Tyr Ser Val Pro Glu Glu Ala 
        35                  40                  45              


Lys His Gly Thr Phe Val Gly Arg Ile Ala Gln Asp Leu Gly Leu Glu 
    50                  55                  60                  


Leu Ala Glu Leu Val Pro Arg Leu Phe Arg Met Ala Ser Lys Asp Arg 
65                  70                  75                  80  


Glu Asp Leu Leu Glu Val Asn Leu Gln Asn Gly Ile Leu Phe Val Asn 
                85                  90                  95      


Ser Arg Ile Asp Arg Glu Glu Leu Cys Gly Arg Ser Ala Glu Cys Ser 
            100                 105                 110         


Ile His Leu Glu Val Ile Val Asp Arg Pro Leu Gln Val Phe His Val 
        115                 120                 125             


Asp Val Glu Val Arg Asp Ile Asn Asp Asn Pro Pro Leu Phe Pro Val 
    130                 135                 140                 


Glu Glu Gln Arg Val Leu Ile Tyr Glu Ser Arg Leu Pro Asp Ser Val 
145                 150                 155                 160 


Phe Pro Leu Glu Gly Ala Ser Asp Ala Asp Val Gly Ser Asn Ser Ile 
                165                 170                 175     


Leu Thr Tyr Lys Leu Ser Ser Ser Glu Tyr Phe Gly Leu Asp Val Lys 
            180                 185                 190         


Ile Asn Ser Asp Asp Asn Lys Gln Ile Gly Leu Leu Leu Lys Lys Ser 
        195                 200                 205             


Leu Asp Arg Glu Glu Ala Pro Ala His Asn Leu Phe Leu Thr Ala Thr 
    210                 215                 220                 


Asp Gly Gly Lys Pro Glu Leu Thr Gly Thr Val Gln Leu Leu Val Thr 
225                 230                 235                 240 


Val Leu Asp Val Asn Asp Asn Ala Pro Thr Phe Glu Gln Ser Glu Tyr 
                245                 250                 255     


Glu Val Arg Ile Phe Glu Asn Ala Asp Asn Gly Thr Thr Val Ile Arg 
            260                 265                 270         


Leu Asn Ala Ser Asp Arg Asp Glu Gly Ala Asn Gly Ala Ile Ser Tyr 
        275                 280                 285             


Ser Phe Asn Ser Leu Val Ala Ala Met Val Ile Asp His Phe Ser Ile 
    290                 295                 300                 


Asp Arg Asn Thr Gly Glu Ile Val Ile Arg Gly Asn Leu Asp Phe Glu 
305                 310                 315                 320 


Gln Glu Asn Leu Tyr Lys Ile Leu Ile Asp Ala Thr Asp Lys Gly His 
                325                 330                 335     


Pro Pro Met Ala Gly His Cys Thr Val Leu Val Arg Ile Leu Asp Lys 
            340                 345                 350         


Asn Asp Asn Val Pro Glu Ile Ala Leu Thr Ser Leu Ser Leu Pro Val 
        355                 360                 365             


Arg Glu Asp Ala Gln Phe Gly Thr Val Ile Ala Leu Ile Ser Val Asn 
    370                 375                 380                 


Asp Leu Asp Ser Gly Ala Asn Gly Gln Val Asn Cys Ser Leu Thr Pro 
385                 390                 395                 400 


His Val Pro Phe Lys Leu Val Ser Thr Phe Lys Asn Tyr Tyr Ser Leu 
                405                 410                 415     


Val Leu Asp Ser Ala Leu Asp Arg Glu Ser Val Ser Ala Tyr Glu Leu 
            420                 425                 430         


Val Val Thr Ala Arg Asp Gly Gly Ser Pro Ser Leu Trp Ala Thr Ala 
        435                 440                 445             


Ser Leu Ser Val Glu Val Ala Asp Met Asn Asp Asn Ala Pro Ala Phe 
    450                 455                 460                 


Ala Gln Pro Glu Tyr Thr Val Phe Val Lys Glu Asn Asn Pro Pro Gly 
465                 470                 475                 480 


Cys His Ile Phe Thr Val Ser Ala Arg Asp Ala Asp Ala Gln Glu Asn 
                485                 490                 495     


Ala Leu Val Ser Tyr Ser Leu Val Glu Arg Arg Val Gly Glu Arg Ala 
            500                 505                 510         


Leu Ser Ser Tyr Ile Ser Val His Ala Glu Ser Gly Lys Val Tyr Ala 
        515                 520                 525             


Leu Gln Pro Leu Asp His Glu Glu Leu Glu Leu Leu Gln Phe Gln Val 
    530                 535                 540                 


Ser Ala Arg Asp Ala Gly Val Pro Pro Leu Gly Ser Asn Val Thr Leu 
545                 550                 555                 560 


Gln Val Phe Val Leu Asp Glu Asn Asp Asn Ala Pro Ala Leu Leu Ala 
                565                 570                 575     


Pro Arg Val Gly Gly Thr Gly Gly Ala Val Ser Glu Leu Val Pro Arg 
            580                 585                 590         


Ser Leu Gly Ala Gly Gln Val Val Ala Lys Val Arg Ala Val Asp Ala 
        595                 600                 605             


Asp Ser Gly Tyr Asn Ala Trp Leu Ser Tyr Glu Leu Gln Pro Pro Ala 
    610                 615                 620                 


Ser Ser Ala Arg Phe Pro Phe Arg Val Gly Leu Tyr Thr Gly Glu Ile 
625                 630                 635                 640 


Ser Thr Thr Arg Val Leu Asp Glu Ala Asp Ser Pro Arg His Arg Leu 
                645                 650                 655     


Leu Val Leu Val Lys Asp His Gly Glu Pro Ala Leu Thr Ala Thr Ala 
            660                 665                 670         


Thr Val Leu Val Ser Leu Val Glu Ser Gly Gln Ala Pro Lys Ala Ser 
        675                 680                 685             


Ser Arg Ala Ser Val Gly Ala Ala Gly Pro Glu Ala Ala Leu Val Asp 
    690                 695                 700                 


Val Asn Val Tyr Leu Ile Ile Ala Ile Cys Ala Val Ser Ser Leu Leu 
705                 710                 715                 720 


Val Leu Thr Leu Leu Leu Tyr Thr Ala Leu Arg Cys Ser Ala Pro Pro 
                725                 730                 735     


Thr Glu Gly Ala Cys Thr Ala Asp Lys Pro Thr Leu Val Cys Ser Ser 
            740                 745                 750         


Ala Val Gly Ser Trp Ser Tyr Ser Gln Gln Arg Arg Gln Arg Val Cys 
        755                 760                 765             


Ser Gly Glu Gly Pro Pro Lys Met Asp Leu Met Ala Phe Ser Pro Ser 
    770                 775                 780                 


Leu Ser Pro Cys Pro Ile Met Met Gly Lys Ala Glu Asn Gln Asp Leu 
785                 790                 795                 800 


Asn Glu Asp His Asp Ala Lys Pro Arg Gln Pro Asn Pro Asp Trp Arg 
                805                 810                 815     


Tyr Ser Ala Ser Leu Arg Ala Gly Met His Ser Ser Val His Leu Glu 
            820                 825                 830         


Glu Ala Gly Ile Leu Arg Ala Gly Pro Gly Gly Pro Asp Gln Gln Trp 
        835                 840                 845             


Pro Thr Val Ser Ser Ala Thr Pro Glu Pro Glu Ala Gly Glu Val Ser 
    850                 855                 860                 


Pro Pro Val Gly Ala Gly Val Asn Ser Asn Ser Trp Thr Phe Lys Tyr 
865                 870                 875                 880 


Gly Pro Gly Asn Pro Lys Gln Ser Gly Pro Gly Glu Leu Pro Asp Lys 
                885                 890                 895     


Phe Ile Ile Pro Gly Ser Pro Ala Ile Ile Ser Ile Arg Gln Glu Pro 
            900                 905                 910         


Thr Asn Ser Gln Ile Asp Lys Ser Asp Phe Ile Thr Phe Gly Lys Lys 
        915                 920                 925             


Glu Glu Thr Lys Lys Lys Lys Lys Lys Lys Lys Gly Asn Lys Thr Gln 
    930                 935                 940                 


Glu Lys Lys Glu Lys Gly Asn Ser Thr Thr Asp Asn Ser Asp Gln 
945                 950                 955                 

<210>  2172
<211>  4641
<212>  DNA
<213>  Homo sapiens

<400>  2172
ccatgaagtt atagctagcc aacattcaaa tttcttctat tactgcatca ttccctgact     60

gttgaatgat ggcggacgca gaagaaatgg attaataaat tccggaacat acagtatttt    120

atctttatgc ggaagatctt ctaatggaaa taaaaccaga ggtatttgac atggtgttta    180

ccccggagga tagattggga aagcaatgtc tgctcctccc gcttctgctc ctcgcagcct    240

ggaaggtggg gagcggccag ctccactact ccgtacccga ggaggccaaa cacggcacct    300

tcgtgggccg gatcgcgcag gacctggggc tggagctggc ggagctggtg ccgcgcctgt    360

tcaggatggc ctccaaagac cgcgaggacc ttctggaggt aaatctgcag aatggcattt    420

tgtttgtgaa ttctcggatc gaccgcgagg agctgtgcgg gcggagcgcg gagtgcagca    480

tccacctgga ggtgatcgtg gacaggccgc tgcaggtttt ccatgtggac gtggaggtga    540

gggacattaa cgacaacccg cccttgttcc cggtagagga acaaagagtg ctgatttacg    600

aatctaggct gccagattct gtgtttccac tggagggcgc gtccgatgca gatgttggct    660

caaattccat cttaacctat aaactcagtt ctagcgaata cttcgggcta gatgtgaaaa    720

taaacagtga tgacaataaa caaattgggc tcttattaaa gaaatccttg gacagagagg    780

aagctcctgc acacaactta ttcctgacag ccacagatgg gggcaaacct gagctcacag    840

gcactgttca gctgctggtc acagtgctgg atgtgaatga taatgctccc actttcgaac    900

agtctgaata cgaagtaaga atattcgaaa atgcagacaa cggaacaaca gttatcagac    960

tgaatgcttc tgatcgggat gaaggagcga atggggcaat ttcatattct tttaatagcc   1020

ttgttgcagc catggttatt gaccacttta gcatagatcg aaatacggga gaaatagtga   1080

ttcggggtaa tttggatttt gaacaagaaa acttatacaa aatcctcatt gacgccacgg   1140

acaaaggcca tcctcccatg gcgggtcatt gcaccgtttt agtgagaatt ttggataaaa   1200

atgataacgt ccctgagata gcactgactt ccttatcctt gcctgtacgt gaagacgctc   1260

aatttggtac tgtcatcgcc ctaattagcg tgaacgacct cgattcaggt gccaacgggc   1320

aggtgaactg ctcgctgacg cctcacgtcc ctttcaagct ggtgtccacc ttcaagaatt   1380

actactcgtt ggtgctggac agtgccctgg accgcgagag cgtgtcggcc tatgagttgg   1440

tggtaaccgc gcgggacggg ggctcgcctt cgctgtgggc caccgccagc ttgtctgtgg   1500

aggtggccga catgaatgac aatgctccgg cgttcgcgca gcccgagtac acagtgttcg   1560

tgaaggagaa caacccgccg ggctgccaca tcttcacggt gtctgcgcga gacgcggacg   1620

cgcaggagaa cgcgctggtg tcctactcgc tggtggagcg gcgggtgggc gagcgcgcgt   1680

tgtcgagcta catttcggtg cacgcggaga gcggcaaggt gtacgcgctg cagccgctgg   1740

accacgagga gctagagctg ctgcagtttc agccacgaca gcccaaccct gactggcgtt   1800

actctgcctc cctgagagca ggcatgcaca gctctgtgca cctagaggag gctggcattc   1860

tacgggctgg tccaggaggg cctgatcagc agtggccaac agtatccagt gcaacaccag   1920

aaccagaggc aggagaagtg tcccctccag tcggtgcggg tgtcaacagc aacagctgga   1980

cctttaaata cggaccaggc aaccccaaac aatccggtcc cggtgagttg cccgacaaat   2040

tcattatccc aggatctcct gcaatcatct ccatccggca ggagcctact aacagccaaa   2100

ttgacaaaag tgacttcata accttcggca aaaaggagga gaccaagaaa aagaagaaaa   2160

agaagaaggg taacaagacc caggagaaaa aagagaaagg gaacagcacg actgacaaca   2220

gtgaccagtg aggtcctcaa atggaaacaa gccacttagc cagtttttgt aataatggca   2280

aatctctccc atgtagcaat tccctgctcc tttttcctat ctacatgagc cctcttagag   2340

acctcagaaa tctgcagaaa gttccctgtg tctgtctaga acgcatttaa caggttttgt   2400

cgtaaaagct ttactaagtc tggtgttaac tctttctctc cactctggct tgttttcaga   2460

acctaaaaag cagacccaag tttcctttct cctccgccgc aaaggagagg cttcccagcc   2520

ccgccagtga gaggttggac tctctgccct gtgctccggg gatcctgtct tgatgacact   2580

tgcagggcag gctgaaaagt tttgagattg agcagcttgg gagtttgtgg ccactgggta   2640

tgtgtggcta ccgcgggtat gcgagtgcca gatattggct gagacgagcc agcttagact   2700

aattggtaca aggaaggcaa gaaaacaaag acaaataaac agcggaagtt atcagtatgg   2760

aggggaagtg taaacttaaa gggaccagac tttctaaatc ttacaactca agaggtggca   2820

gccaccctct aggagacaaa actaccccca ctgacaaggc tttaggagac cctaaagtct   2880

gttggctgtg acgtcattat acctaaaatc tgcatcatac ctgcaagcca acagttcagt   2940

gttttaacag agaaccaccc tgggaaacag aagcagatct gatgtgtttc ctatacatgt   3000

cctgtgctca ctttattaaa aattcttttg cacacaatgt ttatgaaaag gccagatcct   3060

tttccaatac ttatgcaaaa gcaaaagaaa accccgacac ctcacctttc gctgtttgtt   3120

gtttcataga tttatttaaa aaaagagaaa gtctatagct ataaatcttt aaagagaaat   3180

atgaatacaa ttcccctaaa ctctcctcaa aagagaattc agtctacagc catttaaatg   3240

atcattgctg ctacagaagt gctttaagag aattgcctga aacatctgta ttatatcggc   3300

cacctgccaa tcacagcttt actctttcag gtcactctgg ggctgcctct tgcatgtatt   3360

actaaataaa atgatctctc tttctctctc tctctctctt ttctaagaaa caattatgtg   3420

cactttgata cacaaccttc tctaaccaac tatatatcaa gacccaaaaa ttgaagaaaa   3480

atattgtttt ctcatacagt gagcagattt ttcaatctac taattctgtg acttgtcttg   3540

gtgtgctagc ctacaccttc tctttggttt agttttcctt ttctataaca ctctgaattg   3600

ctaatcttac taacacctat gatgttacct gaaatcaatc tcccatatgt atgctgtatg   3660

ctatgctaag actcctgaaa tatacttact ctgtgcttgt gtatgtgaat gttaatgcaa   3720

ctattaccta gagtgaactt taagctttat tgttgaatgt aattccatta tatttccttt   3780

tgtacacctg tgaaaaagtg gagtagtgtt tttttaacca ttgttaatca gcttttgtgt   3840

atgaaagaca cagtaaaatt tctttcttaa atcaagatac tggtgattca aggaatttta   3900

tttatggtcc agccaagagc catctcgtgc caagacttct gctggcaagg gaatggataa   3960

agctgttttg ttctagtaac aattttggaa tgaatactga caatattcca tgagggtgtg   4020

caagcacaaa ttttaccaat ctgacctctt tgaagttgca gaatgctttg aaattctaat   4080

ggtatctgaa atatcagctc atagaaagta acaaaatttg ctgtcacctt aaataagaca   4140

ttttaatttt gttataatgt acaatttaga agtttgatta attatattat ctatttaggc   4200

attaatataa aagaggtagg agtctgttat ttaaaaaaag cattaaattt aaaaaaaaac   4260

tgtcttgtct acttttagct tcattctccc atattttgaa gggtgtgtaa cttcagctct   4320

gcaggattgc atggggtaaa acttgttacc aacacatgtg aaccattgct acattgtagg   4380

ttgtgatcat tttgccccac tgaagcccat gtatctgacc ttacgtgcct tttgaactag   4440

gagaatcggg ctaatttatt aatgatgata attataatgt atctgtacag cactttttac   4500

atttgcgaag tgctttccaa tccatgttag ttactagtta ttacagctgt aaggataaaa   4560

cacgtcatgt ggattcattt tgaattggtg ctattggtat ttcctctgtt attgctaata   4620

aatgaaaatg gtggtatgaa a                                             4641


<210>  2173
<211>  695
<212>  PRT
<213>  Homo sapiens

<400>  2173


Met Glu Ile Lys Pro Glu Val Phe Asp Met Val Phe Thr Pro Glu Asp 
1               5                   10                  15      


Arg Leu Gly Lys Gln Cys Leu Leu Leu Pro Leu Leu Leu Leu Ala Ala 
            20                  25                  30          


Trp Lys Val Gly Ser Gly Gln Leu His Tyr Ser Val Pro Glu Glu Ala 
        35                  40                  45              


Lys His Gly Thr Phe Val Gly Arg Ile Ala Gln Asp Leu Gly Leu Glu 
    50                  55                  60                  


Leu Ala Glu Leu Val Pro Arg Leu Phe Arg Met Ala Ser Lys Asp Arg 
65                  70                  75                  80  


Glu Asp Leu Leu Glu Val Asn Leu Gln Asn Gly Ile Leu Phe Val Asn 
                85                  90                  95      


Ser Arg Ile Asp Arg Glu Glu Leu Cys Gly Arg Ser Ala Glu Cys Ser 
            100                 105                 110         


Ile His Leu Glu Val Ile Val Asp Arg Pro Leu Gln Val Phe His Val 
        115                 120                 125             


Asp Val Glu Val Arg Asp Ile Asn Asp Asn Pro Pro Leu Phe Pro Val 
    130                 135                 140                 


Glu Glu Gln Arg Val Leu Ile Tyr Glu Ser Arg Leu Pro Asp Ser Val 
145                 150                 155                 160 


Phe Pro Leu Glu Gly Ala Ser Asp Ala Asp Val Gly Ser Asn Ser Ile 
                165                 170                 175     


Leu Thr Tyr Lys Leu Ser Ser Ser Glu Tyr Phe Gly Leu Asp Val Lys 
            180                 185                 190         


Ile Asn Ser Asp Asp Asn Lys Gln Ile Gly Leu Leu Leu Lys Lys Ser 
        195                 200                 205             


Leu Asp Arg Glu Glu Ala Pro Ala His Asn Leu Phe Leu Thr Ala Thr 
    210                 215                 220                 


Asp Gly Gly Lys Pro Glu Leu Thr Gly Thr Val Gln Leu Leu Val Thr 
225                 230                 235                 240 


Val Leu Asp Val Asn Asp Asn Ala Pro Thr Phe Glu Gln Ser Glu Tyr 
                245                 250                 255     


Glu Val Arg Ile Phe Glu Asn Ala Asp Asn Gly Thr Thr Val Ile Arg 
            260                 265                 270         


Leu Asn Ala Ser Asp Arg Asp Glu Gly Ala Asn Gly Ala Ile Ser Tyr 
        275                 280                 285             


Ser Phe Asn Ser Leu Val Ala Ala Met Val Ile Asp His Phe Ser Ile 
    290                 295                 300                 


Asp Arg Asn Thr Gly Glu Ile Val Ile Arg Gly Asn Leu Asp Phe Glu 
305                 310                 315                 320 


Gln Glu Asn Leu Tyr Lys Ile Leu Ile Asp Ala Thr Asp Lys Gly His 
                325                 330                 335     


Pro Pro Met Ala Gly His Cys Thr Val Leu Val Arg Ile Leu Asp Lys 
            340                 345                 350         


Asn Asp Asn Val Pro Glu Ile Ala Leu Thr Ser Leu Ser Leu Pro Val 
        355                 360                 365             


Arg Glu Asp Ala Gln Phe Gly Thr Val Ile Ala Leu Ile Ser Val Asn 
    370                 375                 380                 


Asp Leu Asp Ser Gly Ala Asn Gly Gln Val Asn Cys Ser Leu Thr Pro 
385                 390                 395                 400 


His Val Pro Phe Lys Leu Val Ser Thr Phe Lys Asn Tyr Tyr Ser Leu 
                405                 410                 415     


Val Leu Asp Ser Ala Leu Asp Arg Glu Ser Val Ser Ala Tyr Glu Leu 
            420                 425                 430         


Val Val Thr Ala Arg Asp Gly Gly Ser Pro Ser Leu Trp Ala Thr Ala 
        435                 440                 445             


Ser Leu Ser Val Glu Val Ala Asp Met Asn Asp Asn Ala Pro Ala Phe 
    450                 455                 460                 


Ala Gln Pro Glu Tyr Thr Val Phe Val Lys Glu Asn Asn Pro Pro Gly 
465                 470                 475                 480 


Cys His Ile Phe Thr Val Ser Ala Arg Asp Ala Asp Ala Gln Glu Asn 
                485                 490                 495     


Ala Leu Val Ser Tyr Ser Leu Val Glu Arg Arg Val Gly Glu Arg Ala 
            500                 505                 510         


Leu Ser Ser Tyr Ile Ser Val His Ala Glu Ser Gly Lys Val Tyr Ala 
        515                 520                 525             


Leu Gln Pro Leu Asp His Glu Glu Leu Glu Leu Leu Gln Phe Gln Pro 
    530                 535                 540                 


Arg Gln Pro Asn Pro Asp Trp Arg Tyr Ser Ala Ser Leu Arg Ala Gly 
545                 550                 555                 560 


Met His Ser Ser Val His Leu Glu Glu Ala Gly Ile Leu Arg Ala Gly 
                565                 570                 575     


Pro Gly Gly Pro Asp Gln Gln Trp Pro Thr Val Ser Ser Ala Thr Pro 
            580                 585                 590         


Glu Pro Glu Ala Gly Glu Val Ser Pro Pro Val Gly Ala Gly Val Asn 
        595                 600                 605             


Ser Asn Ser Trp Thr Phe Lys Tyr Gly Pro Gly Asn Pro Lys Gln Ser 
    610                 615                 620                 


Gly Pro Gly Glu Leu Pro Asp Lys Phe Ile Ile Pro Gly Ser Pro Ala 
625                 630                 635                 640 


Ile Ile Ser Ile Arg Gln Glu Pro Thr Asn Ser Gln Ile Asp Lys Ser 
                645                 650                 655     


Asp Phe Ile Thr Phe Gly Lys Lys Glu Glu Thr Lys Lys Lys Lys Lys 
            660                 665                 670         


Lys Lys Lys Gly Asn Lys Thr Gln Glu Lys Lys Glu Lys Gly Asn Ser 
        675                 680                 685             


Thr Thr Asp Asn Ser Asp Gln 
    690                 695 

<210>  2174
<211>  5433
<212>  DNA
<213>  Homo sapiens

<400>  2174
ccatgaagtt atagctagcc aacattcaaa tttcttctat tactgcatca ttccctgact     60

gttgaatgat ggcggacgca gaagaaatgg attaataaat tccggaacat acagtatttt    120

atctttatgc ggaagatctt ctaatggaaa taaaaccaga ggtatttgac atggtgttta    180

ccccggagga tagattggga aagcaatgtc tgctcctccc gcttctgctc ctcgcagcct    240

ggaaggtggg gagcggccag ctccactact ccgtacccga ggaggccaaa cacggcacct    300

tcgtgggccg gatcgcgcag gacctggggc tggagctggc ggagctggtg ccgcgcctgt    360

tcaggatggc ctccaaagac cgcgaggacc ttctggaggt aaatctgcag aatggcattt    420

tgtttgtgaa ttctcggatc gaccgcgagg agctgtgcgg gcggagcgcg gagtgcagca    480

tccacctgga ggtgatcgtg gacaggccgc tgcaggtttt ccatgtggac gtggaggtga    540

gggacattaa cgacaacccg cccttgttcc cggtagagga acaaagagtg ctgatttacg    600

aatctaggct gccagattct gtgtttccac tggagggcgc gtccgatgca gatgttggct    660

caaattccat cttaacctat aaactcagtt ctagcgaata cttcgggcta gatgtgaaaa    720

taaacagtga tgacaataaa caaattgggc tcttattaaa gaaatccttg gacagagagg    780

aagctcctgc acacaactta ttcctgacag ccacagatgg gggcaaacct gagctcacag    840

gcactgttca gctgctggtc acagtgctgg atgtgaatga taatgctccc actttcgaac    900

agtctgaata cgaagtaaga atattcgaaa atgcagacaa cggaacaaca gttatcagac    960

tgaatgcttc tgatcgggat gaaggagcga atggggcaat ttcatattct tttaatagcc   1020

ttgttgcagc catggttatt gaccacttta gcatagatcg aaatacggga gaaatagtga   1080

ttcggggtaa tttggatttt gaacaagaaa acttatacaa aatcctcatt gacgccacgg   1140

acaaaggcca tcctcccatg gcgggtcatt gcaccgtttt agtgagaatt ttggataaaa   1200

atgataacgt ccctgagata gcactgactt ccttatcctt gcctgtacgt gaagacgctc   1260

aatttggtac tgtcatcgcc ctaattagcg tgaacgacct cgattcaggt gccaacgggc   1320

aggtgaactg ctcgctgacg cctcacgtcc ctttcaagct ggtgtccacc ttcaagaatt   1380

actactcgtt ggtgctggac agtgccctgg accgcgagag cgtgtcggcc tatgagttgg   1440

tggtaaccgc gcgggacggg ggctcgcctt cgctgtgggc caccgccagc ttgtctgtgg   1500

aggtggccga catgaatgac aatgctccgg cgttcgcgca gcccgagtac acagtgttcg   1560

tgaaggagaa caacccgccg ggctgccaca tcttcacggt gtctgcgcga gacgcggacg   1620

cgcaggagaa cgcgctggtg tcctactcgc tggtggagcg gcgggtgggc gagcgcgcgt   1680

tgtcgagcta catttcggtg cacgcggaga gcggcaaggt gtacgcgctg cagccgctgg   1740

accacgagga gctagagctg ctgcagtttc aggtgagcgc gcgcgacgcg ggcgtgccgc   1800

ctctgggcag caacgtgacg ctgcaggtgt tcgtgctgga cgagaacgac aacgcgccgg   1860

cgctgctggc gcctcgggtg ggtggtactg gtggtgcagt gagcgagctg gtgccgcggt   1920

cactgggtgc aggccaagtg gtggcgaagg tgcgcgcagt tgacgccgac tcaggctaca   1980

acgcgtggct ttcgtatgag ctgcagcccc cggcaagcag cgctcgcttc ccgtttcgcg   2040

tggggctgta cacgggcgag atcagcacca ctcgtgtcct ggacgaagcg gactctccgc   2100

gccaccggct gctggtgctg gtgaaagacc acggtgagcc ggcgctgaca gcgacggcca   2160

cggttctggt gtcgctggtg gagagtggcc aggctccaaa ggcgtcatca cgggcgtcgg   2220

tgggcgccgc gggcccagag gcggcgctgg tggatgtcaa cgtgtacctg atcatcgcca   2280

tctgcgcggt atccagcctg ctggtcctca cgctactgct gtacacagcg ctgcggtgct   2340

cggcgccacc caccgagggc gcgtgcacgg cggacaagcc cacgctggtg tgctccagcg   2400

cagtggggag ctggtcgtac tcgcagcaga ggcggcagag ggtgtgctcc ggggagggcc   2460

cacccaagat ggatctcatg gcctttagcc ccagcctttc accttgtcct attatgatgg   2520

gtaaggcgga gaatcaggat ttaaatgaag atcatgatgc caaaccacga cagcccaacc   2580

ctgactggcg ttactctgcc tccctgagag caggcatgca cagctctgtg cacctagagg   2640

aggctggcat tctacgggct ggtccaggag ggcctgatca gcagtggcca acagtatcca   2700

gtgcaacacc agaaccagag gcaggagaag tgtcccctcc agtcggtgcg ggtgtcaaca   2760

gcaacagctg gacctttaaa tacggaccag gcaaccccaa acaatccggt cccggtgagt   2820

tgcccgacaa attcattatc ccaggatctc ctgcaatcat ctccatccgg caggagccta   2880

ctaacagcca aattgacaaa agtgacttca taaccttcgg caaaaaggag gagaccaaga   2940

aaaagaagaa aaagaagaag ggtaacaaga cccaggagaa aaaagagaaa gggaacagca   3000

cgactgacaa cagtgaccag tgaggtcctc aaatggaaac aagccactta gccagttttt   3060

gtaataatgg caaatctctc ccatgtagca attccctgct cctttttcct atctacatga   3120

gccctcttag agacctcaga aatctgcaga aagttccctg tgtctgtcta gaacgcattt   3180

aacaggtttt gtcgtaaaag ctttactaag tctggtgtta actctttctc tccactctgg   3240

cttgttttca gaacctaaaa agcagaccca agtttccttt ctcctccgcc gcaaaggaga   3300

ggcttcccag ccccgccagt gagaggttgg actctctgcc ctgtgctccg gggatcctgt   3360

cttgatgaca cttgcagggc aggctgaaaa gttttgagat tgagcagctt gggagtttgt   3420

ggccactggg tatgtgtggc taccgcgggt atgcgagtgc cagatattgg ctgagacgag   3480

ccagcttaga ctaattggta caaggaaggc aagaaaacaa agacaaataa acagcggaag   3540

ttatcagtat ggaggggaag tgtaaactta aagggaccag actttctaaa tcttacaact   3600

caagaggtgg cagccaccct ctaggagaca aaactacccc cactgacaag gctttaggag   3660

accctaaagt ctgttggctg tgacgtcatt atacctaaaa tctgcatcat acctgcaagc   3720

caacagttca gtgttttaac agagaaccac cctgggaaac agaagcagat ctgatgtgtt   3780

tcctatacat gtcctgtgct cactttatta aaaattcttt tgcacacaat gtttatgaaa   3840

aggccagatc cttttccaat acttatgcaa aagcaaaaga aaaccccgac acctcacctt   3900

tcgctgtttg ttgtttcata gatttattta aaaaaagaga aagtctatag ctataaatct   3960

ttaaagagaa atatgaatac aattccccta aactctcctc aaaagagaat tcagtctaca   4020

gccatttaaa tgatcattgc tgctacagaa gtgctttaag agaattgcct gaaacatctg   4080

tattatatcg gccacctgcc aatcacagct ttactctttc aggtcactct ggggctgcct   4140

cttgcatgta ttactaaata aaatgatctc tctttctctc tctctctctc ttttctaaga   4200

aacaattatg tgcactttga tacacaacct tctctaacca actatatatc aagacccaaa   4260

aattgaagaa aaatattgtt ttctcataca gtgagcagat ttttcaatct actaattctg   4320

tgacttgtct tggtgtgcta gcctacacct tctctttggt ttagttttcc ttttctataa   4380

cactctgaat tgctaatctt actaacacct atgatgttac ctgaaatcaa tctcccatat   4440

gtatgctgta tgctatgcta agactcctga aatatactta ctctgtgctt gtgtatgtga   4500

atgttaatgc aactattacc tagagtgaac tttaagcttt attgttgaat gtaattccat   4560

tatatttcct tttgtacacc tgtgaaaaag tggagtagtg tttttttaac cattgttaat   4620

cagcttttgt gtatgaaaga cacagtaaaa tttctttctt aaatcaagat actggtgatt   4680

caaggaattt tatttatggt ccagccaaga gccatctcgt gccaagactt ctgctggcaa   4740

gggaatggat aaagctgttt tgttctagta acaattttgg aatgaatact gacaatattc   4800

catgagggtg tgcaagcaca aattttacca atctgacctc tttgaagttg cagaatgctt   4860

tgaaattcta atggtatctg aaatatcagc tcatagaaag taacaaaatt tgctgtcacc   4920

ttaaataaga cattttaatt ttgttataat gtacaattta gaagtttgat taattatatt   4980

atctatttag gcattaatat aaaagaggta ggagtctgtt atttaaaaaa agcattaaat   5040

ttaaaaaaaa actgtcttgt ctacttttag cttcattctc ccatattttg aagggtgtgt   5100

aacttcagct ctgcaggatt gcatggggta aaacttgtta ccaacacatg tgaaccattg   5160

ctacattgta ggttgtgatc attttgcccc actgaagccc atgtatctga ccttacgtgc   5220

cttttgaact aggagaatcg ggctaattta ttaatgatga taattataat gtatctgtac   5280

agcacttttt acatttgcga agtgctttcc aatccatgtt agttactagt tattacagct   5340

gtaaggataa aacacgtcat gtggattcat tttgaattgg tgctattggt atttcctctg   5400

ttattgctaa taaatgaaaa tggtggtatg aaa                                5433


<210>  2175
<211>  959
<212>  PRT
<213>  Homo sapiens

<400>  2175


Met Glu Ile Lys Pro Glu Val Phe Asp Met Val Phe Thr Pro Glu Asp 
1               5                   10                  15      


Arg Leu Gly Lys Gln Cys Leu Leu Leu Pro Leu Leu Leu Leu Ala Ala 
            20                  25                  30          


Trp Lys Val Gly Ser Gly Gln Leu His Tyr Ser Val Pro Glu Glu Ala 
        35                  40                  45              


Lys His Gly Thr Phe Val Gly Arg Ile Ala Gln Asp Leu Gly Leu Glu 
    50                  55                  60                  


Leu Ala Glu Leu Val Pro Arg Leu Phe Arg Met Ala Ser Lys Asp Arg 
65                  70                  75                  80  


Glu Asp Leu Leu Glu Val Asn Leu Gln Asn Gly Ile Leu Phe Val Asn 
                85                  90                  95      


Ser Arg Ile Asp Arg Glu Glu Leu Cys Gly Arg Ser Ala Glu Cys Ser 
            100                 105                 110         


Ile His Leu Glu Val Ile Val Asp Arg Pro Leu Gln Val Phe His Val 
        115                 120                 125             


Asp Val Glu Val Arg Asp Ile Asn Asp Asn Pro Pro Leu Phe Pro Val 
    130                 135                 140                 


Glu Glu Gln Arg Val Leu Ile Tyr Glu Ser Arg Leu Pro Asp Ser Val 
145                 150                 155                 160 


Phe Pro Leu Glu Gly Ala Ser Asp Ala Asp Val Gly Ser Asn Ser Ile 
                165                 170                 175     


Leu Thr Tyr Lys Leu Ser Ser Ser Glu Tyr Phe Gly Leu Asp Val Lys 
            180                 185                 190         


Ile Asn Ser Asp Asp Asn Lys Gln Ile Gly Leu Leu Leu Lys Lys Ser 
        195                 200                 205             


Leu Asp Arg Glu Glu Ala Pro Ala His Asn Leu Phe Leu Thr Ala Thr 
    210                 215                 220                 


Asp Gly Gly Lys Pro Glu Leu Thr Gly Thr Val Gln Leu Leu Val Thr 
225                 230                 235                 240 


Val Leu Asp Val Asn Asp Asn Ala Pro Thr Phe Glu Gln Ser Glu Tyr 
                245                 250                 255     


Glu Val Arg Ile Phe Glu Asn Ala Asp Asn Gly Thr Thr Val Ile Arg 
            260                 265                 270         


Leu Asn Ala Ser Asp Arg Asp Glu Gly Ala Asn Gly Ala Ile Ser Tyr 
        275                 280                 285             


Ser Phe Asn Ser Leu Val Ala Ala Met Val Ile Asp His Phe Ser Ile 
    290                 295                 300                 


Asp Arg Asn Thr Gly Glu Ile Val Ile Arg Gly Asn Leu Asp Phe Glu 
305                 310                 315                 320 


Gln Glu Asn Leu Tyr Lys Ile Leu Ile Asp Ala Thr Asp Lys Gly His 
                325                 330                 335     


Pro Pro Met Ala Gly His Cys Thr Val Leu Val Arg Ile Leu Asp Lys 
            340                 345                 350         


Asn Asp Asn Val Pro Glu Ile Ala Leu Thr Ser Leu Ser Leu Pro Val 
        355                 360                 365             


Arg Glu Asp Ala Gln Phe Gly Thr Val Ile Ala Leu Ile Ser Val Asn 
    370                 375                 380                 


Asp Leu Asp Ser Gly Ala Asn Gly Gln Val Asn Cys Ser Leu Thr Pro 
385                 390                 395                 400 


His Val Pro Phe Lys Leu Val Ser Thr Phe Lys Asn Tyr Tyr Ser Leu 
                405                 410                 415     


Val Leu Asp Ser Ala Leu Asp Arg Glu Ser Val Ser Ala Tyr Glu Leu 
            420                 425                 430         


Val Val Thr Ala Arg Asp Gly Gly Ser Pro Ser Leu Trp Ala Thr Ala 
        435                 440                 445             


Ser Leu Ser Val Glu Val Ala Asp Met Asn Asp Asn Ala Pro Ala Phe 
    450                 455                 460                 


Ala Gln Pro Glu Tyr Thr Val Phe Val Lys Glu Asn Asn Pro Pro Gly 
465                 470                 475                 480 


Cys His Ile Phe Thr Val Ser Ala Arg Asp Ala Asp Ala Gln Glu Asn 
                485                 490                 495     


Ala Leu Val Ser Tyr Ser Leu Val Glu Arg Arg Val Gly Glu Arg Ala 
            500                 505                 510         


Leu Ser Ser Tyr Ile Ser Val His Ala Glu Ser Gly Lys Val Tyr Ala 
        515                 520                 525             


Leu Gln Pro Leu Asp His Glu Glu Leu Glu Leu Leu Gln Phe Gln Val 
    530                 535                 540                 


Ser Ala Arg Asp Ala Gly Val Pro Pro Leu Gly Ser Asn Val Thr Leu 
545                 550                 555                 560 


Gln Val Phe Val Leu Asp Glu Asn Asp Asn Ala Pro Ala Leu Leu Ala 
                565                 570                 575     


Pro Arg Val Gly Gly Thr Gly Gly Ala Val Ser Glu Leu Val Pro Arg 
            580                 585                 590         


Ser Leu Gly Ala Gly Gln Val Val Ala Lys Val Arg Ala Val Asp Ala 
        595                 600                 605             


Asp Ser Gly Tyr Asn Ala Trp Leu Ser Tyr Glu Leu Gln Pro Pro Ala 
    610                 615                 620                 


Ser Ser Ala Arg Phe Pro Phe Arg Val Gly Leu Tyr Thr Gly Glu Ile 
625                 630                 635                 640 


Ser Thr Thr Arg Val Leu Asp Glu Ala Asp Ser Pro Arg His Arg Leu 
                645                 650                 655     


Leu Val Leu Val Lys Asp His Gly Glu Pro Ala Leu Thr Ala Thr Ala 
            660                 665                 670         


Thr Val Leu Val Ser Leu Val Glu Ser Gly Gln Ala Pro Lys Ala Ser 
        675                 680                 685             


Ser Arg Ala Ser Val Gly Ala Ala Gly Pro Glu Ala Ala Leu Val Asp 
    690                 695                 700                 


Val Asn Val Tyr Leu Ile Ile Ala Ile Cys Ala Val Ser Ser Leu Leu 
705                 710                 715                 720 


Val Leu Thr Leu Leu Leu Tyr Thr Ala Leu Arg Cys Ser Ala Pro Pro 
                725                 730                 735     


Thr Glu Gly Ala Cys Thr Ala Asp Lys Pro Thr Leu Val Cys Ser Ser 
            740                 745                 750         


Ala Val Gly Ser Trp Ser Tyr Ser Gln Gln Arg Arg Gln Arg Val Cys 
        755                 760                 765             


Ser Gly Glu Gly Pro Pro Lys Met Asp Leu Met Ala Phe Ser Pro Ser 
    770                 775                 780                 


Leu Ser Pro Cys Pro Ile Met Met Gly Lys Ala Glu Asn Gln Asp Leu 
785                 790                 795                 800 


Asn Glu Asp His Asp Ala Lys Pro Arg Gln Pro Asn Pro Asp Trp Arg 
                805                 810                 815     


Tyr Ser Ala Ser Leu Arg Ala Gly Met His Ser Ser Val His Leu Glu 
            820                 825                 830         


Glu Ala Gly Ile Leu Arg Ala Gly Pro Gly Gly Pro Asp Gln Gln Trp 
        835                 840                 845             


Pro Thr Val Ser Ser Ala Thr Pro Glu Pro Glu Ala Gly Glu Val Ser 
    850                 855                 860                 


Pro Pro Val Gly Ala Gly Val Asn Ser Asn Ser Trp Thr Phe Lys Tyr 
865                 870                 875                 880 


Gly Pro Gly Asn Pro Lys Gln Ser Gly Pro Gly Glu Leu Pro Asp Lys 
                885                 890                 895     


Phe Ile Ile Pro Gly Ser Pro Ala Ile Ile Ser Ile Arg Gln Glu Pro 
            900                 905                 910         


Thr Asn Ser Gln Ile Asp Lys Ser Asp Phe Ile Thr Phe Gly Lys Lys 
        915                 920                 925             


Glu Glu Thr Lys Lys Lys Lys Lys Lys Lys Lys Gly Asn Lys Thr Gln 
    930                 935                 940                 


Glu Lys Lys Glu Lys Gly Asn Ser Thr Thr Asp Asn Ser Asp Gln 
945                 950                 955                 

<210>  2176
<211>  5377
<212>  DNA
<213>  Homo sapiens

<400>  2176
attccttttc gcactggaaa gacgctccac tctctttcac tctttggatg cacaacaatg     60

gccacacatc gagattgaaa tgaagggata aaaacattcc tataaattcg aaggcaagtt    120

ttgctgacta gaaaaacaag ccaataattt gaaatggtgt gcccgaatgg atacgaccca    180

gggggccgac atctactgct gtttattata attctagcag cttgggaggc agggagaggc    240

cagctccact actcggtccc cgaggaggct aaacatggca acttcgtggg ccgcatcgcg    300

caggacctgg ggctggagct ggcggagctg gtgccgcgcc tgttccgggc ggtgtgcaaa    360

ttccgtgggg atcttctgga ggtaaatctg cagaatggca ttttgtttgt gaattctcgg    420

atcgaccgcg aggagctgtg cgggcggagc gcggagtgca gcatccacct ggaggtgatc    480

gtggaaaggc cgctgcaggt tttccatgtg gacgtggagg tgaaggacat taacgacaac    540

cctccggtgt tcccagcgac acaaaggaat ctgttcatcg cggaatccag gccgcttgac    600

tctcggtttc cactagaggg cgcgtccgat gcagatatcg gggagaacgc cctgctcact    660

tacagactga gccccaatga gtatttcttc ctggacgtgc caaccagcaa ccagcaggta    720

aaacctcttg gacttgtatt acggaaactt ttagacagag aagaaactcc ggagcttcat    780

ttattgctca cggccaccga tggaggcaaa cccgagctga ctggcaccgt tcaattactc    840

atcacggtac tggacaacaa tgacaatgcc ccagtgttcg acagaaccct gtatacggtg    900

aaattaccag aaaacgtttc tatcggaacg ctggtgattc accccaatgc ctcagattta    960

gacgaaggct tgaatgggga tattatttac tccttctcca gtgatgtttc tccagatata   1020

aaatccaagt tccacatgga ccccttaagt ggggcaatca cagtgatagg acatatggat   1080

tttgaagaaa gtagagcaca caagatccca gtcgaggctg tcgataaagg cttcccaccc   1140

ctggctggtc attgtacagt tcttgtggaa gttgtggatg taaatgacaa tgctccacag   1200

ttgactctca cttccctgtc tctccctatt ccagaggacg cccaaccagg taccgtcatc   1260

acattgatta gcgtgtttga ccgagatttt ggagtcaacg gacaggttac ctgctccctg   1320

acgccccgcg ttcccttcaa gttggtgtcc accttcaaga attactattc attggtgctg   1380

gacagcgctc tggaccgcga gagtgtgtcc gcctatgagc tggtggttac cgcgcgggac   1440

gggggctcgc cttctctgtg ggccactgct agcgtgtccg tggaggtggc cgacgtgaac   1500

gacaacgccc cggcgttcgc gcagcccgag tatacggtgt tcgtgaagga gaacaacccg   1560

ccgggctgcc acatcttcac tgtgtcggcg ggggacgcgg acgcgcagaa gaacgcgctg   1620

gtgtcctact cgctggtgga gctgcgggtg ggcgagcgcg cgctgtcgag ctacgtgtca   1680

gtgcacgcgg agagcggcaa ggtgtacgcg ctgcagccgt tggaccacga ggagctggag   1740

ctgttgcagt tccaggtgag cgcgcgcgat gcgggcgtgc cgcctctggg cagcaacgtg   1800

acgctgcagg tgttcgtgct ggacgagaac gacaacgcgc cggcactgct ggcgcctcgg   1860

gtgggtggca ctggtggcgc agtgagagag cttgtgccgc ggtctgtggg cgcgggccat   1920

gtggtggcga aggtacgtgc agttgacgct gactcaggct acaacgcgtg gctttcgtat   1980

gagttgcaac cggtggcggc cggtgcgagc atcccgttcc gcgtggggct gtacactggt   2040

gagatcagca cgacacgagc cctagatgag acggacgcac cgcgccaccg ccttctggtg   2100

cttgtgaagg accacgggga gccctcgctg acagccacag ccaccgtgct ggtgtcgctg   2160

gtggaaagcg gccaggcacc aaaggcgtcg tcgcgggcat cgttgggcat tgcaggccca   2220

gagaccgagc tggtggatgt caacgtgtac ctgatcatcg ccatctgcgc ggtgtccagt   2280

ctgttggtgc ttaccctgct gctgtacacg gcgttgcggt gctcagcgcc gtcctctgag   2340

ggcgcatgta gtttggtaaa gcccactctg gtgtgctcca gcgcggtggg gagctggtca   2400

ttctcccagc agaggcggca gagggtgtgc tctggggagg gcccacccaa gacagacctc   2460

atggccttca gtcccagcct tcctcagggt ccatcctcta cagacaatcc acgacagccc   2520

aaccctgact ggcgttactc tgcctccctg agagcaggca tgcacagctc tgtgcaccta   2580

gaggaggctg gcattctacg ggctggtcca ggagggcctg atcagcagtg gccaacagta   2640

tccagtgcaa caccagaacc agaggcagga gaagtgtccc ctccagtcgg tgcgggtgtc   2700

aacagcaaca gctggacctt taaatacgga ccaggcaacc ccaaacaatc cggtcccggt   2760

gagttgcccg acaaattcat tatcccagga tctcctgcaa tcatctccat ccggcaggag   2820

cctactaaca gccaaattga caaaagtgac ttcataacct tcggcaaaaa ggaggagacc   2880

aagaaaaaga agaaaaagaa gaagggtaac aagacccagg agaaaaaaga gaaagggaac   2940

agcacgactg acaacagtga ccagtgaggt cctcaaatgg aaacaagcca cttagccagt   3000

ttttgtaata atggcaaatc tctcccatgt agcaattccc tgctcctttt tcctatctac   3060

atgagccctc ttagagacct cagaaatctg cagaaagttc cctgtgtctg tctagaacgc   3120

atttaacagg ttttgtcgta aaagctttac taagtctggt gttaactctt tctctccact   3180

ctggcttgtt ttcagaacct aaaaagcaga cccaagtttc ctttctcctc cgccgcaaag   3240

gagaggcttc ccagccccgc cagtgagagg ttggactctc tgccctgtgc tccggggatc   3300

ctgtcttgat gacacttgca gggcaggctg aaaagttttg agattgagca gcttgggagt   3360

ttgtggccac tgggtatgtg tggctaccgc gggtatgcga gtgccagata ttggctgaga   3420

cgagccagct tagactaatt ggtacaagga aggcaagaaa acaaagacaa ataaacagcg   3480

gaagttatca gtatggaggg gaagtgtaaa cttaaaggga ccagactttc taaatcttac   3540

aactcaagag gtggcagcca ccctctagga gacaaaacta cccccactga caaggcttta   3600

ggagacccta aagtctgttg gctgtgacgt cattatacct aaaatctgca tcatacctgc   3660

aagccaacag ttcagtgttt taacagagaa ccaccctggg aaacagaagc agatctgatg   3720

tgtttcctat acatgtcctg tgctcacttt attaaaaatt cttttgcaca caatgtttat   3780

gaaaaggcca gatccttttc caatacttat gcaaaagcaa aagaaaaccc cgacacctca   3840

cctttcgctg tttgttgttt catagattta tttaaaaaaa gagaaagtct atagctataa   3900

atctttaaag agaaatatga atacaattcc cctaaactct cctcaaaaga gaattcagtc   3960

tacagccatt taaatgatca ttgctgctac agaagtgctt taagagaatt gcctgaaaca   4020

tctgtattat atcggccacc tgccaatcac agctttactc tttcaggtca ctctggggct   4080

gcctcttgca tgtattacta aataaaatga tctctctttc tctctctctc tctcttttct   4140

aagaaacaat tatgtgcact ttgatacaca accttctcta accaactata tatcaagacc   4200

caaaaattga agaaaaatat tgttttctca tacagtgagc agatttttca atctactaat   4260

tctgtgactt gtcttggtgt gctagcctac accttctctt tggtttagtt ttccttttct   4320

ataacactct gaattgctaa tcttactaac acctatgatg ttacctgaaa tcaatctccc   4380

atatgtatgc tgtatgctat gctaagactc ctgaaatata cttactctgt gcttgtgtat   4440

gtgaatgtta atgcaactat tacctagagt gaactttaag ctttattgtt gaatgtaatt   4500

ccattatatt tccttttgta cacctgtgaa aaagtggagt agtgtttttt taaccattgt   4560

taatcagctt ttgtgtatga aagacacagt aaaatttctt tcttaaatca agatactggt   4620

gattcaagga attttattta tggtccagcc aagagccatc tcgtgccaag acttctgctg   4680

gcaagggaat ggataaagct gttttgttct agtaacaatt ttggaatgaa tactgacaat   4740

attccatgag ggtgtgcaag cacaaatttt accaatctga cctctttgaa gttgcagaat   4800

gctttgaaat tctaatggta tctgaaatat cagctcatag aaagtaacaa aatttgctgt   4860

caccttaaat aagacatttt aattttgtta taatgtacaa tttagaagtt tgattaatta   4920

tattatctat ttaggcatta atataaaaga ggtaggagtc tgttatttaa aaaaagcatt   4980

aaatttaaaa aaaaactgtc ttgtctactt ttagcttcat tctcccatat tttgaagggt   5040

gtgtaacttc agctctgcag gattgcatgg ggtaaaactt gttaccaaca catgtgaacc   5100

attgctacat tgtaggttgt gatcattttg ccccactgaa gcccatgtat ctgaccttac   5160

gtgccttttg aactaggaga atcgggctaa tttattaatg atgataatta taatgtatct   5220

gtacagcact ttttacattt gcgaagtgct ttccaatcca tgttagttac tagttattac   5280

agctgtaagg ataaaacacg tcatgtggat tcattttgaa ttggtgctat tggtatttcc   5340

tctgttattg ctaataaatg aaaatggtgg tatgaaa                            5377


<210>  2177
<211>  937
<212>  PRT
<213>  Homo sapiens

<400>  2177


Met Val Cys Pro Asn Gly Tyr Asp Pro Gly Gly Arg His Leu Leu Leu 
1               5                   10                  15      


Phe Ile Ile Ile Leu Ala Ala Trp Glu Ala Gly Arg Gly Gln Leu His 
            20                  25                  30          


Tyr Ser Val Pro Glu Glu Ala Lys His Gly Asn Phe Val Gly Arg Ile 
        35                  40                  45              


Ala Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Pro Arg Leu Phe 
    50                  55                  60                  


Arg Ala Val Cys Lys Phe Arg Gly Asp Leu Leu Glu Val Asn Leu Gln 
65                  70                  75                  80  


Asn Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Gly Arg Ser Ala Glu Cys Ser Ile His Leu Glu Val Ile Val Glu Arg 
            100                 105                 110         


Pro Leu Gln Val Phe His Val Asp Val Glu Val Lys Asp Ile Asn Asp 
        115                 120                 125             


Asn Pro Pro Val Phe Pro Ala Thr Gln Arg Asn Leu Phe Ile Ala Glu 
    130                 135                 140                 


Ser Arg Pro Leu Asp Ser Arg Phe Pro Leu Glu Gly Ala Ser Asp Ala 
145                 150                 155                 160 


Asp Ile Gly Glu Asn Ala Leu Leu Thr Tyr Arg Leu Ser Pro Asn Glu 
                165                 170                 175     


Tyr Phe Phe Leu Asp Val Pro Thr Ser Asn Gln Gln Val Lys Pro Leu 
            180                 185                 190         


Gly Leu Val Leu Arg Lys Leu Leu Asp Arg Glu Glu Thr Pro Glu Leu 
        195                 200                 205             


His Leu Leu Leu Thr Ala Thr Asp Gly Gly Lys Pro Glu Leu Thr Gly 
    210                 215                 220                 


Thr Val Gln Leu Leu Ile Thr Val Leu Asp Asn Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Val Phe Asp Arg Thr Leu Tyr Thr Val Lys Leu Pro Glu Asn Val Ser 
                245                 250                 255     


Ile Gly Thr Leu Val Ile His Pro Asn Ala Ser Asp Leu Asp Glu Gly 
            260                 265                 270         


Leu Asn Gly Asp Ile Ile Tyr Ser Phe Ser Ser Asp Val Ser Pro Asp 
        275                 280                 285             


Ile Lys Ser Lys Phe His Met Asp Pro Leu Ser Gly Ala Ile Thr Val 
    290                 295                 300                 


Ile Gly His Met Asp Phe Glu Glu Ser Arg Ala His Lys Ile Pro Val 
305                 310                 315                 320 


Glu Ala Val Asp Lys Gly Phe Pro Pro Leu Ala Gly His Cys Thr Val 
                325                 330                 335     


Leu Val Glu Val Val Asp Val Asn Asp Asn Ala Pro Gln Leu Thr Leu 
            340                 345                 350         


Thr Ser Leu Ser Leu Pro Ile Pro Glu Asp Ala Gln Pro Gly Thr Val 
        355                 360                 365             


Ile Thr Leu Ile Ser Val Phe Asp Arg Asp Phe Gly Val Asn Gly Gln 
    370                 375                 380                 


Val Thr Cys Ser Leu Thr Pro Arg Val Pro Phe Lys Leu Val Ser Thr 
385                 390                 395                 400 


Phe Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu 
                405                 410                 415     


Ser Val Ser Ala Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser 
            420                 425                 430         


Pro Ser Leu Trp Ala Thr Ala Ser Val Ser Val Glu Val Ala Asp Val 
        435                 440                 445             


Asn Asp Asn Ala Pro Ala Phe Ala Gln Pro Glu Tyr Thr Val Phe Val 
    450                 455                 460                 


Lys Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Gly 
465                 470                 475                 480 


Asp Ala Asp Ala Gln Lys Asn Ala Leu Val Ser Tyr Ser Leu Val Glu 
                485                 490                 495     


Leu Arg Val Gly Glu Arg Ala Leu Ser Ser Tyr Val Ser Val His Ala 
            500                 505                 510         


Glu Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu 
        515                 520                 525             


Glu Leu Leu Gln Phe Gln Val Ser Ala Arg Asp Ala Gly Val Pro Pro 
    530                 535                 540                 


Leu Gly Ser Asn Val Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp 
545                 550                 555                 560 


Asn Ala Pro Ala Leu Leu Ala Pro Arg Val Gly Gly Thr Gly Gly Ala 
                565                 570                 575     


Val Arg Glu Leu Val Pro Arg Ser Val Gly Ala Gly His Val Val Ala 
            580                 585                 590         


Lys Val Arg Ala Val Asp Ala Asp Ser Gly Tyr Asn Ala Trp Leu Ser 
        595                 600                 605             


Tyr Glu Leu Gln Pro Val Ala Ala Gly Ala Ser Ile Pro Phe Arg Val 
    610                 615                 620                 


Gly Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Ala Leu Asp Glu Thr 
625                 630                 635                 640 


Asp Ala Pro Arg His Arg Leu Leu Val Leu Val Lys Asp His Gly Glu 
                645                 650                 655     


Pro Ser Leu Thr Ala Thr Ala Thr Val Leu Val Ser Leu Val Glu Ser 
            660                 665                 670         


Gly Gln Ala Pro Lys Ala Ser Ser Arg Ala Ser Leu Gly Ile Ala Gly 
        675                 680                 685             


Pro Glu Thr Glu Leu Val Asp Val Asn Val Tyr Leu Ile Ile Ala Ile 
    690                 695                 700                 


Cys Ala Val Ser Ser Leu Leu Val Leu Thr Leu Leu Leu Tyr Thr Ala 
705                 710                 715                 720 


Leu Arg Cys Ser Ala Pro Ser Ser Glu Gly Ala Cys Ser Leu Val Lys 
                725                 730                 735     


Pro Thr Leu Val Cys Ser Ser Ala Val Gly Ser Trp Ser Phe Ser Gln 
            740                 745                 750         


Gln Arg Arg Gln Arg Val Cys Ser Gly Glu Gly Pro Pro Lys Thr Asp 
        755                 760                 765             


Leu Met Ala Phe Ser Pro Ser Leu Pro Gln Gly Pro Ser Ser Thr Asp 
    770                 775                 780                 


Asn Pro Arg Gln Pro Asn Pro Asp Trp Arg Tyr Ser Ala Ser Leu Arg 
785                 790                 795                 800 


Ala Gly Met His Ser Ser Val His Leu Glu Glu Ala Gly Ile Leu Arg 
                805                 810                 815     


Ala Gly Pro Gly Gly Pro Asp Gln Gln Trp Pro Thr Val Ser Ser Ala 
            820                 825                 830         


Thr Pro Glu Pro Glu Ala Gly Glu Val Ser Pro Pro Val Gly Ala Gly 
        835                 840                 845             


Val Asn Ser Asn Ser Trp Thr Phe Lys Tyr Gly Pro Gly Asn Pro Lys 
    850                 855                 860                 


Gln Ser Gly Pro Gly Glu Leu Pro Asp Lys Phe Ile Ile Pro Gly Ser 
865                 870                 875                 880 


Pro Ala Ile Ile Ser Ile Arg Gln Glu Pro Thr Asn Ser Gln Ile Asp 
                885                 890                 895     


Lys Ser Asp Phe Ile Thr Phe Gly Lys Lys Glu Glu Thr Lys Lys Lys 
            900                 905                 910         


Lys Lys Lys Lys Lys Gly Asn Lys Thr Gln Glu Lys Lys Glu Lys Gly 
        915                 920                 925             


Asn Ser Thr Thr Asp Asn Ser Asp Gln 
    930                 935         

<210>  2178
<211>  5413
<212>  DNA
<213>  Homo sapiens

<400>  2178
gtcaatgttc aaagtctttt ctctgacagc atctgtctct aaaggccgaa caacgggaga     60

tgcagcggaa ttggattaaa agactctgaa agtacagtcg ttcatcttta tattaagata    120

atattttctg ataggaaacg actatttaac atggattatc actggcgagg agagctggga    180

tcctggcgac tactactctt gcttctgctc ctcgcagcct ggaaggtggg gagcggccag    240

ctccactact ccgtccccga ggaggccaaa cacggcacct tcgtgggccg gatcgcgcag    300

gacctggggc tggagctggc ggagctggtg ccgcgcctgt tccgggtggc gtccaaaaga    360

caccgggacc ttctggaggt aagtctgcag aatggcattt tgtttgtgaa ttctcggatc    420

gaccgcgagg agctgtgcgg gcggagcgcg gagtgcagca tccacctgga ggtgatcgtg    480

gacaggccgc tgcaggtttt ccatgtggac gtggaggtga aggatgttaa tgacaacccg    540

ccagtgttcc gggtaaaaga ccaaaagctg tttgtttcag aatccagaat gccagactct    600

cggtttccgc tagagggcgc gtccgatgca gatgttggag ctaactccgt gttaacctac    660

aggcttagct ctcatgatta cttcatgcta gatgtgaatt caaagaacga tgagaataaa    720

ctggttgagc tcgtattaag aaaatccttg gacagagagg acgctcctgc gcaccactta    780

ttcctgacag ccacagatgg gggcaaacct gagctcacag gcactgttca gctgctggtc    840

acagtgctgg atgtgaatga taatgctccc actttcgaac agtctgaata cgaagtaaga    900

atattcgaaa acgcagacaa cggaacaaca gttatcaaac tgaatgcttc tgatccggat    960

gaaggagcca atggggcaat ttcatattct tttaatagcc ttgttgaaac tatggttatt   1020

gaccacttta gcatagatcg aaatacggga gaaatagtga ttcggggtaa tttggatttt   1080

gaacaagaaa acttatacaa aatcctcatt gacgccacgg acaaaggcca tcctcccatg   1140

gcgggtcatt gcaccgtttt agtgagaatt ttggataaaa atgataacgt ccctgagata   1200

gcactgactt ccttatcctt gcctgtacgt gaagacgctc aatttggtac tgtcatcgcc   1260

ctaattagcg tgaacgacct cgattcaggt gccaacgggc aggtgacctg ctccctgatg   1320

ccccatgtcc ccttcaagct ggtgtccacc ttcaagaatt actactcgtt ggtgctggac   1380

agcgccctgg accgcgagag agtgtcggcc tatgagttgg tggtaaccgc gcgggacggg   1440

ggctcgcctt cgctgtgggc caccgccagc ttgtctgtgg aggtggccga cgtgaacgac   1500

aatgctccgg cgttcgcgca gcccgagtac acggtgttcg tgaaggagaa caacccgccg   1560

ggctgccaca tcttcacggt gtctgcgcga gacgcggacg cgcaggagaa cgcgctggtg   1620

tcctactcgc ttgtggagcg gcgggtgggc gagcgctcgc tgtcgagcta catttcggtg   1680

cacacggaga gcggcaaggt gtacgcgctg cagccgctgg accacgagga gctagagctg   1740

ctgcagttcc aggtgagcgc gcgcgacgcg ggcgtgccgc ctctgggcag caacgtgacg   1800

ctgcaggtgt tcgtgctgga cgagaatgac aacgcgccgg cactgctgga gcctcgggtg   1860

ggtggcactg gtggcgcagc gagcaagctg gtgccgcggt ctgtgggcgc gggccacgtg   1920

gtagcgaagg tgcgcgcagt ggacgccgac tcgggctaca acgcgtggct ttcgtatgag   1980

ctgcagccag ctgcaagcag ccctcgcatc ccgttccgcg tggggctgta cacgggcgag   2040

atcagcacca ctcgtgtcct ggacgaagcg gactctccgc gccaccgtct gctggtcctg   2100

gtgaaggatc atggtgaacc tgcgctgacc gccacggcca cggttctggt gtcgctggtg   2160

gagagcggcc aggctccaaa agcgtcatcg aggcagtcgg ctggcgtttt gggtccggaa   2220

gcggcgctgg tggatgtcaa cgtgtacctg atcatcgcca tctgcgcggt atccagcctg   2280

ctggtgctca cgctgctgct gtacactgcg ctgcggtgct cagcactgcc cactgagggc   2340

gggtgccggg cgggcaagcc cactctggtg tgctccagtg cggtggggag ctggtcatac   2400

tcgcaacaac agccgcagag ggtgtgctct ggtgaggggc caccgaagac ggacctcatg   2460

gccttcagcc cctgccttcc tcctgatctg ggatcagttg atgtaggcga agagcaagat   2520

ttaaatgttg atcatggcct caaaccacga cagcccaacc ctgactggcg ttactctgcc   2580

tccctgagag caggcatgca cagctctgtg cacctagagg aggctggcat tctacgggct   2640

ggtccaggag ggcctgatca gcagtggcca acagtatcca gtgcaacacc agaaccagag   2700

gcaggagaag tgtcccctcc agtcggtgcg ggtgtcaaca gcaacagctg gacctttaaa   2760

tacggaccag gcaaccccaa acaatccggt cccggtgagt tgcccgacaa attcattatc   2820

ccaggatctc ctgcaatcat ctccatccgg caggagccta ctaacagcca aattgacaaa   2880

agtgacttca taaccttcgg caaaaaggag gagaccaaga aaaagaagaa aaagaagaag   2940

ggtaacaaga cccaggagaa aaaagagaaa gggaacagca cgactgacaa cagtgaccag   3000

tgaggtcctc aaatggaaac aagccactta gccagttttt gtaataatgg caaatctctc   3060

ccatgtagca attccctgct cctttttcct atctacatga gccctcttag agacctcaga   3120

aatctgcaga aagttccctg tgtctgtcta gaacgcattt aacaggtttt gtcgtaaaag   3180

ctttactaag tctggtgtta actctttctc tccactctgg cttgttttca gaacctaaaa   3240

agcagaccca agtttccttt ctcctccgcc gcaaaggaga ggcttcccag ccccgccagt   3300

gagaggttgg actctctgcc ctgtgctccg gggatcctgt cttgatgaca cttgcagggc   3360

aggctgaaaa gttttgagat tgagcagctt gggagtttgt ggccactggg tatgtgtggc   3420

taccgcgggt atgcgagtgc cagatattgg ctgagacgag ccagcttaga ctaattggta   3480

caaggaaggc aagaaaacaa agacaaataa acagcggaag ttatcagtat ggaggggaag   3540

tgtaaactta aagggaccag actttctaaa tcttacaact caagaggtgg cagccaccct   3600

ctaggagaca aaactacccc cactgacaag gctttaggag accctaaagt ctgttggctg   3660

tgacgtcatt atacctaaaa tctgcatcat acctgcaagc caacagttca gtgttttaac   3720

agagaaccac cctgggaaac agaagcagat ctgatgtgtt tcctatacat gtcctgtgct   3780

cactttatta aaaattcttt tgcacacaat gtttatgaaa aggccagatc cttttccaat   3840

acttatgcaa aagcaaaaga aaaccccgac acctcacctt tcgctgtttg ttgtttcata   3900

gatttattta aaaaaagaga aagtctatag ctataaatct ttaaagagaa atatgaatac   3960

aattccccta aactctcctc aaaagagaat tcagtctaca gccatttaaa tgatcattgc   4020

tgctacagaa gtgctttaag agaattgcct gaaacatctg tattatatcg gccacctgcc   4080

aatcacagct ttactctttc aggtcactct ggggctgcct cttgcatgta ttactaaata   4140

aaatgatctc tctttctctc tctctctctc ttttctaaga aacaattatg tgcactttga   4200

tacacaacct tctctaacca actatatatc aagacccaaa aattgaagaa aaatattgtt   4260

ttctcataca gtgagcagat ttttcaatct actaattctg tgacttgtct tggtgtgcta   4320

gcctacacct tctctttggt ttagttttcc ttttctataa cactctgaat tgctaatctt   4380

actaacacct atgatgttac ctgaaatcaa tctcccatat gtatgctgta tgctatgcta   4440

agactcctga aatatactta ctctgtgctt gtgtatgtga atgttaatgc aactattacc   4500

tagagtgaac tttaagcttt attgttgaat gtaattccat tatatttcct tttgtacacc   4560

tgtgaaaaag tggagtagtg tttttttaac cattgttaat cagcttttgt gtatgaaaga   4620

cacagtaaaa tttctttctt aaatcaagat actggtgatt caaggaattt tatttatggt   4680

ccagccaaga gccatctcgt gccaagactt ctgctggcaa gggaatggat aaagctgttt   4740

tgttctagta acaattttgg aatgaatact gacaatattc catgagggtg tgcaagcaca   4800

aattttacca atctgacctc tttgaagttg cagaatgctt tgaaattcta atggtatctg   4860

aaatatcagc tcatagaaag taacaaaatt tgctgtcacc ttaaataaga cattttaatt   4920

ttgttataat gtacaattta gaagtttgat taattatatt atctatttag gcattaatat   4980

aaaagaggta ggagtctgtt atttaaaaaa agcattaaat ttaaaaaaaa actgtcttgt   5040

ctacttttag cttcattctc ccatattttg aagggtgtgt aacttcagct ctgcaggatt   5100

gcatggggta aaacttgtta ccaacacatg tgaaccattg ctacattgta ggttgtgatc   5160

attttgcccc actgaagccc atgtatctga ccttacgtgc cttttgaact aggagaatcg   5220

ggctaattta ttaatgatga taattataat gtatctgtac agcacttttt acatttgcga   5280

agtgctttcc aatccatgtt agttactagt tattacagct gtaaggataa aacacgtcat   5340

gtggattcat tttgaattgg tgctattggt atttcctctg ttattgctaa taaatgaaaa   5400

tggtggtatg aaa                                                      5413


<210>  2179
<211>  950
<212>  PRT
<213>  Homo sapiens

<400>  2179


Met Asp Tyr His Trp Arg Gly Glu Leu Gly Ser Trp Arg Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Ala Ala Trp Lys Val Gly Ser Gly Gln Leu His 
            20                  25                  30          


Tyr Ser Val Pro Glu Glu Ala Lys His Gly Thr Phe Val Gly Arg Ile 
        35                  40                  45              


Ala Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Pro Arg Leu Phe 
    50                  55                  60                  


Arg Val Ala Ser Lys Arg His Arg Asp Leu Leu Glu Val Ser Leu Gln 
65                  70                  75                  80  


Asn Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Gly Arg Ser Ala Glu Cys Ser Ile His Leu Glu Val Ile Val Asp Arg 
            100                 105                 110         


Pro Leu Gln Val Phe His Val Asp Val Glu Val Lys Asp Val Asn Asp 
        115                 120                 125             


Asn Pro Pro Val Phe Arg Val Lys Asp Gln Lys Leu Phe Val Ser Glu 
    130                 135                 140                 


Ser Arg Met Pro Asp Ser Arg Phe Pro Leu Glu Gly Ala Ser Asp Ala 
145                 150                 155                 160 


Asp Val Gly Ala Asn Ser Val Leu Thr Tyr Arg Leu Ser Ser His Asp 
                165                 170                 175     


Tyr Phe Met Leu Asp Val Asn Ser Lys Asn Asp Glu Asn Lys Leu Val 
            180                 185                 190         


Glu Leu Val Leu Arg Lys Ser Leu Asp Arg Glu Asp Ala Pro Ala His 
        195                 200                 205             


His Leu Phe Leu Thr Ala Thr Asp Gly Gly Lys Pro Glu Leu Thr Gly 
    210                 215                 220                 


Thr Val Gln Leu Leu Val Thr Val Leu Asp Val Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Thr Phe Glu Gln Ser Glu Tyr Glu Val Arg Ile Phe Glu Asn Ala Asp 
                245                 250                 255     


Asn Gly Thr Thr Val Ile Lys Leu Asn Ala Ser Asp Pro Asp Glu Gly 
            260                 265                 270         


Ala Asn Gly Ala Ile Ser Tyr Ser Phe Asn Ser Leu Val Glu Thr Met 
        275                 280                 285             


Val Ile Asp His Phe Ser Ile Asp Arg Asn Thr Gly Glu Ile Val Ile 
    290                 295                 300                 


Arg Gly Asn Leu Asp Phe Glu Gln Glu Asn Leu Tyr Lys Ile Leu Ile 
305                 310                 315                 320 


Asp Ala Thr Asp Lys Gly His Pro Pro Met Ala Gly His Cys Thr Val 
                325                 330                 335     


Leu Val Arg Ile Leu Asp Lys Asn Asp Asn Val Pro Glu Ile Ala Leu 
            340                 345                 350         


Thr Ser Leu Ser Leu Pro Val Arg Glu Asp Ala Gln Phe Gly Thr Val 
        355                 360                 365             


Ile Ala Leu Ile Ser Val Asn Asp Leu Asp Ser Gly Ala Asn Gly Gln 
    370                 375                 380                 


Val Thr Cys Ser Leu Met Pro His Val Pro Phe Lys Leu Val Ser Thr 
385                 390                 395                 400 


Phe Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu 
                405                 410                 415     


Arg Val Ser Ala Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser 
            420                 425                 430         


Pro Ser Leu Trp Ala Thr Ala Ser Leu Ser Val Glu Val Ala Asp Val 
        435                 440                 445             


Asn Asp Asn Ala Pro Ala Phe Ala Gln Pro Glu Tyr Thr Val Phe Val 
    450                 455                 460                 


Lys Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Arg 
465                 470                 475                 480 


Asp Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu 
                485                 490                 495     


Arg Arg Val Gly Glu Arg Ser Leu Ser Ser Tyr Ile Ser Val His Thr 
            500                 505                 510         


Glu Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu 
        515                 520                 525             


Glu Leu Leu Gln Phe Gln Val Ser Ala Arg Asp Ala Gly Val Pro Pro 
    530                 535                 540                 


Leu Gly Ser Asn Val Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp 
545                 550                 555                 560 


Asn Ala Pro Ala Leu Leu Glu Pro Arg Val Gly Gly Thr Gly Gly Ala 
                565                 570                 575     


Ala Ser Lys Leu Val Pro Arg Ser Val Gly Ala Gly His Val Val Ala 
            580                 585                 590         


Lys Val Arg Ala Val Asp Ala Asp Ser Gly Tyr Asn Ala Trp Leu Ser 
        595                 600                 605             


Tyr Glu Leu Gln Pro Ala Ala Ser Ser Pro Arg Ile Pro Phe Arg Val 
    610                 615                 620                 


Gly Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Val Leu Asp Glu Ala 
625                 630                 635                 640 


Asp Ser Pro Arg His Arg Leu Leu Val Leu Val Lys Asp His Gly Glu 
                645                 650                 655     


Pro Ala Leu Thr Ala Thr Ala Thr Val Leu Val Ser Leu Val Glu Ser 
            660                 665                 670         


Gly Gln Ala Pro Lys Ala Ser Ser Arg Gln Ser Ala Gly Val Leu Gly 
        675                 680                 685             


Pro Glu Ala Ala Leu Val Asp Val Asn Val Tyr Leu Ile Ile Ala Ile 
    690                 695                 700                 


Cys Ala Val Ser Ser Leu Leu Val Leu Thr Leu Leu Leu Tyr Thr Ala 
705                 710                 715                 720 


Leu Arg Cys Ser Ala Leu Pro Thr Glu Gly Gly Cys Arg Ala Gly Lys 
                725                 730                 735     


Pro Thr Leu Val Cys Ser Ser Ala Val Gly Ser Trp Ser Tyr Ser Gln 
            740                 745                 750         


Gln Gln Pro Gln Arg Val Cys Ser Gly Glu Gly Pro Pro Lys Thr Asp 
        755                 760                 765             


Leu Met Ala Phe Ser Pro Cys Leu Pro Pro Asp Leu Gly Ser Val Asp 
    770                 775                 780                 


Val Gly Glu Glu Gln Asp Leu Asn Val Asp His Gly Leu Lys Pro Arg 
785                 790                 795                 800 


Gln Pro Asn Pro Asp Trp Arg Tyr Ser Ala Ser Leu Arg Ala Gly Met 
                805                 810                 815     


His Ser Ser Val His Leu Glu Glu Ala Gly Ile Leu Arg Ala Gly Pro 
            820                 825                 830         


Gly Gly Pro Asp Gln Gln Trp Pro Thr Val Ser Ser Ala Thr Pro Glu 
        835                 840                 845             


Pro Glu Ala Gly Glu Val Ser Pro Pro Val Gly Ala Gly Val Asn Ser 
    850                 855                 860                 


Asn Ser Trp Thr Phe Lys Tyr Gly Pro Gly Asn Pro Lys Gln Ser Gly 
865                 870                 875                 880 


Pro Gly Glu Leu Pro Asp Lys Phe Ile Ile Pro Gly Ser Pro Ala Ile 
                885                 890                 895     


Ile Ser Ile Arg Gln Glu Pro Thr Asn Ser Gln Ile Asp Lys Ser Asp 
            900                 905                 910         


Phe Ile Thr Phe Gly Lys Lys Glu Glu Thr Lys Lys Lys Lys Lys Lys 
        915                 920                 925             


Lys Lys Gly Asn Lys Thr Gln Glu Lys Lys Glu Lys Gly Asn Ser Thr 
    930                 935                 940                 


Thr Asp Asn Ser Asp Gln 
945                 950 

<210>  2180
<211>  2215
<212>  DNA
<213>  Homo sapiens

<400>  2180
ggtgaggggc caccgaagac ggacctcatg gccttcagcc cctgccttcc tcctgatctg     60

ggatcagttg atgtaggcga agagcaagat ttaaatgttg atcatggcct caaaccacga    120

cagcccaacc ctgactggcg ttactctgcc tccctgagag caggcatgca cagctctgtg    180

cacctagagg aggctggcat tctacgggct ggtccaggag ggcctgatca gcagtggcca    240

acagtatcca gtgcaacacc agaaccagag gcaggagaag tgtcccctcc agtcggtgcg    300

ggtgtcaaca gcaacagctg gacctttaaa tacggaccag gcaaccccaa acaatccggt    360

cccggtgagt tgcccgacaa attcattatc ccaggatctc ctgcaatcat ctccatccgg    420

caggagccta ctaacagcca aattgacaaa agtgacttca taaccttcgg caaaaaggag    480

gagaccaaga aaaagaagaa aaagaagaag ggtaacaaga cccaggagaa aaaagagaaa    540

gggaacagca cgactgacaa cagtgaccag tgaggtcctc aaatggaaac aagccactta    600

gccagttttt gtaataatgg caaatctctc ccatgtagca attccctgct cctttttcct    660

atctacatga gccctcttag agacctcaga aatctgcaga aagttccctg tgtctgtcta    720

gaacgcattt aacaggtttt gtcgtaaaag ctttactaag tctggtgtta actctttctc    780

tccactctgg cttgttttca gaacctaaaa agcagaccca agtttccttt ctcctccgcc    840

gcaaaggaga ggcttcccag ccccgccagt gagaggttgg actctctgcc ctgtgctccg    900

gggatcctgt cttgatgaca cttgcagggc aggctgaaaa gttttgagat tgagcagctt    960

gggagtttgt ggccactggg tatgtgtggc taccgcgggt atgcgagtgc cagatattgg   1020

ctgagacgag ccagcttaga ctaattggta caaggaaggc aagaaaacaa agacaaataa   1080

acagcggaag ttatcagtat ggaggggaag tgtaaactta aagggaccag actttctaaa   1140

tcttacaact caagaggtgg cagccaccct ctaggagaca aaactacccc cactgacaag   1200

gctttaggag accctaaagt ctgttggctg tgacgtcatt atacctaaaa tctgcatcat   1260

acctgcaagc caacagttca gtgttttaac agagaaccac cctgggaaac agaagcagat   1320

ctgatgtgtt tcctatacat gtcctgtgct cactttatta aaaattcttt tgcacacaat   1380

gtttatgaaa aggccagatc cttttccaat acttatgcaa aagcaaaaga aaaccccgac   1440

acctcacctt tcgctgtttg ttgtttcata gatttattta aaaaaagaga aagtctatag   1500

ctataaatct ttaaagagaa atatgaatac aattccccta aactctcctc aaaagagaat   1560

tcagtctaca gccatttaaa tgatcattgc tgctacagaa gtgctttaag agaattgcct   1620

gaaacatctg tattatatcg gccacctgcc aatcacagct ttactctttc aggtcactct   1680

ggggctgcct cttgcatgta ttactaaata aaatgatctc tctttctctc tctctctctc   1740

ttttctaaga aacaattatg tgcactttga tacacaacct tctctaacca actatatatc   1800

aagacccaaa aattgaagaa aaatattgtt ttctcataca gtgagcagat ttttcaatct   1860

actaattctg tgacttgtct tggtgtgcta gcctacacct tctctttggt ttagttttcc   1920

ttttctataa cactctgaat tgctaatctt actaacacct atgatgttac ctgaaatcaa   1980

tctcccatat gtatgctgta tgctatgcta agactcctga aatatactta ctctgtgctt   2040

gtgtatgtga atgttaatgc aactattacc tagagtgaac tttaagcttt attgttgaat   2100

gtaattccat tatatttcct tttgtacacc tgtgaaaaag tggagtagtg tttttttaac   2160

cattgttaat cagcttttgt gtatgaaaga cacagtaaaa tttctttctt aaatc        2215


<210>  2181
<211>  181
<212>  PRT
<213>  Homo sapiens

<400>  2181


Met Ala Phe Ser Pro Cys Leu Pro Pro Asp Leu Gly Ser Val Asp Val 
1               5                   10                  15      


Gly Glu Glu Gln Asp Leu Asn Val Asp His Gly Leu Lys Pro Arg Gln 
            20                  25                  30          


Pro Asn Pro Asp Trp Arg Tyr Ser Ala Ser Leu Arg Ala Gly Met His 
        35                  40                  45              


Ser Ser Val His Leu Glu Glu Ala Gly Ile Leu Arg Ala Gly Pro Gly 
    50                  55                  60                  


Gly Pro Asp Gln Gln Trp Pro Thr Val Ser Ser Ala Thr Pro Glu Pro 
65                  70                  75                  80  


Glu Ala Gly Glu Val Ser Pro Pro Val Gly Ala Gly Val Asn Ser Asn 
                85                  90                  95      


Ser Trp Thr Phe Lys Tyr Gly Pro Gly Asn Pro Lys Gln Ser Gly Pro 
            100                 105                 110         


Gly Glu Leu Pro Asp Lys Phe Ile Ile Pro Gly Ser Pro Ala Ile Ile 
        115                 120                 125             


Ser Ile Arg Gln Glu Pro Thr Asn Ser Gln Ile Asp Lys Ser Asp Phe 
    130                 135                 140                 


Ile Thr Phe Gly Lys Lys Glu Glu Thr Lys Lys Lys Lys Lys Lys Lys 
145                 150                 155                 160 


Lys Gly Asn Lys Thr Gln Glu Lys Lys Glu Lys Gly Asn Ser Thr Thr 
                165                 170                 175     


Asp Asn Ser Asp Gln 
            180     

<210>  2182
<211>  5439
<212>  DNA
<213>  Homo sapiens

<400>  2182
acttggacgt tggaataaga tagtaaaact cacaacaaaa ctttgtagaa cttagtcagg     60

aaaagaatct caagcatagc tttaaaaaca gaaattgccc cgagtactaa ggatgagcaa    120

taatgaaatt aaaacatatt gtaataacat tacacaaact atattggaga ctacaaagaa    180

gagattattc atagattata aagcttggaa agaatcaaaa caacacattt ctggaaacag    240

attgtataaa tgctacaaaa gagaaaaata tattttctcc ccacgcaaca caagacctta    300

aagtgattcc ttttaccaga catgactaag tttctttttc atcagtagat ttctgggctc    360

ctatattcac tagagattgc aactcctgga tttctcttac actagaatcc tatttcgagc    420

catatgggag attctgaatt ccagaacaaa agaattttgt aatttaaaat tcgtgattgc    480

tcaatggaat cattttaatt gttacttcat ttctgtcgtt atttaaaact taagtggaga    540

gttttctcag ggataagaaa accacaatca aggtcataca aaacttttag aggcagtcag    600

tctgctaaga aggctccagc aagagaaacg ggatcttctg tttcaacaat cattacttaa    660

gaaaaaatta agaaaatgaa ataagttttg cagaataact gtgaaatttt tattcatgaa    720

atatgtactt acactttggg ccacgtgatg tcactctttg ccgcgatgtt ctctctgaat    780

ccagacaaat acagcccttt tcccatggga aagaggctca attctttttc actctctctg    840

tgctgaacga tggcgaacac agcagaatgg gactgacgaa atcagatgat ttcttctaat    900

ttggaggcaa ttttcactaa ttagaagaag actgagtatt tgaaatgtta tactcaagtc    960

gaggagatcc agagggtcag cctctactgc tctcgcttct gatcctcgca atgtgggtgg   1020

tggggagcgg ccagctccac tactccgtcc cggaggaagc cgaacacggc accttcgtgg   1080

gccgcatcgc gcaggacctg gggctggagc tggcggagct ggtgccgcgc ctgttccagt   1140

tggattccaa aggccgcggg gaccttctgg aggtaaatct gcagaatggc attttgtttg   1200

tgaattctcg gatcgaccgc gaggagctgt gcgggcggag cgcggagtgc agcatccacc   1260

tggaggtgat cgtagacagg ccgctgcagg ttttccatgt ggacgtggag gtgaaggaca   1320

ttaacgacaa ccctccagtg ttcccagcga cacaaaagaa tctgttcatc gcggaatcca   1380

ggccgcttga ctctcggttt ccactagagg gcgcgtccga tgcagatatc ggggagaacg   1440

ccctgctcac ttacagactg agccccaatg agtatttctt cctggacgtg ccaaccagca   1500

accagcaggt aaaacctctt ggacttgtat tacggaaact tttagacaga gaagaaactc   1560

cggagcttca tttattgctc acggccaccg atggaggcaa acccgagctg actggcaccg   1620

ttcaattact catcacggta ctggacaaca atgacaatgc cccagtgttc gacagaaccc   1680

tgtatacggt gaaattacca gaaaacgttt ctatcggaac gctggtgatt caccccaatg   1740

cctcagattt agacgaaggc ttgaatgggg atattattta ctccttctcc agtgatgttt   1800

ctccagatat aaaatccaag ttccacatgg accccttaag tggggcaatc acagtgatag   1860

gacatatgga ttttgaagaa agtagagcac acaagatccc agtcgaggct gtcgataaag   1920

gcttcccacc cctggctggt cattgtacac ttcttgtgga agttgtggat gtaaatgaca   1980

atgctccaca gttgactatc aaaacgctct cggttcctgt aaaagaggac gcacaactgg   2040

ggacagttat tgccctgatt agtgtgatcg acctagacgc agatgccaac gggcaggtta   2100

cctgctccct gacgccccac gtccccttca agctggtgtc cacctacaag aattactact   2160

cgttggtgct ggacagagct ctggaccgcg agagtgtgtc cgcctacgag ctggtggtta   2220

ccgcgcggga cgggggctcg ccttcactgt gggccacggc cagggtgtct gtggaggtgg   2280

ccgacgtgaa cgacaacgca ccagcgttcg cgcagtccga gtacacggtg ttcgtgaagg   2340

agaacaaccc gccgggctgc cacatcttca cggtgtctgc gcgggacgct gacgcgcagg   2400

agaacgccct ggtgtcctac tcgctggtgg agcggcggtt gggcgagcgc tcgctgtcga   2460

gctacgtgtc agtgcacgcg gagagcggca aggtgtacgc gctgcagccg ttggaccacg   2520

aggagctgga gctgctacag ttccaggtga gcgcgcgcga cgcgggcgtg ccgcctctgg   2580

gcagcaacgt gacgctgcag gtgttcgtgc tggacgagaa cgacaatgcg ccggcgctgc   2640

tgacacctcg gatgaggggc actgacggcg cagtgagcga gatggtgctg cggtcggtgg   2700

gcgccggcgt agtggtgggg aaggtgcgcg cagtggacgc cgactcgggc tacaacgcgt   2760

ggctttcata cgagctgcag ccagaaacgg ccagcgcgag catcccgttc cgcgtggggc   2820

tgtacacggg cgagatcagc acaacgcgtg ccctggacga aacggacgca ccgcgccagc   2880

gcctactggt gctggtgaaa gaccacgggg agccagcgct gacggccacg gccactgtgc   2940

tggtgtcgct ggtggagagc ggccaggcgc caaagtcatc gtcgcgggcg tcagtgggtg   3000

ccacgggccc cgaggtgacg ctggtggatg tcaacgtgta cctgatcatc gccatctgcg   3060

cggtgtctag cctgttggtt ctcacgctgc tgctgtacac tgtgctgcgg tgctcggcga   3120

tgcccaccga gggcgagtgc gcgcctggca agccgacgct ggtgtgttct agcgcggtgg   3180

ggagttggtc gtactcgcag cagaggaggc agagggtgtg ctctggcgag ggtaagcaga   3240

agaccgacct catggccttc agcccgggcc tttctccttg tgctggatct acagagcgaa   3300

cgggagaacc ctctgcttcc tcagattcaa ctgggaagcc acgacagccc aaccctgact   3360

ggcgttactc tgcctccctg agagcaggca tgcacagctc tgtgcaccta gaggaggctg   3420

gcattctacg ggctggtcca ggagggcctg atcagcagtg gccaacagta tccagtgcaa   3480

caccagaacc agaggcagga gaagtgtccc ctccagtcgg tgcgggtgtc aacagcaaca   3540

gctggacctt taaatacgga ccaggcaacc ccaaacaatc cggtcccggt gagttgcccg   3600

acaaattcat tatcccagga tctcctgcaa tcatctccat ccggcaggag cctactaaca   3660

gccaaattga caaaagtgac ttcataacct tcggcaaaaa ggaggagacc aagaaaaaga   3720

agaaaaagaa gaagggtaac aagacccagg agaaaaaaga gaaagggaac agcacgactg   3780

acaacagtga ccagtgaggt cctcaaatgg aaacaagcca cttagccagt ttttgtaata   3840

atggcaaatc tctcccatgt agcaattccc tgctcctttt tcctatctac atgagccctc   3900

ttagagacct cagaaatctg cagaaagttc cctgtgtctg tctagaacgc atttaacagg   3960

ttttgtcgta aaagctttac taagtctggt gttaactctt tctctccact ctggcttgtt   4020

ttcagaacct aaaaagcaga cccaagtttc ctttctcctc cgccgcaaag gagaggcttc   4080

ccagccccgc cagtgagagg ttggactctc tgccctgtgc tccggggatc ctgtcttgat   4140

gacacttgca gggcaggctg aaaagttttg agattgagca gcttgggagt ttgtggccac   4200

tgggtatgtg tggctaccgc gggtatgcga gtgccagata ttggctgaga cgagccagct   4260

tagactaatt ggtacaagga aggcaagaaa acaaagacaa ataaacagcg gaagttatca   4320

gtatggaggg gaagtgtaaa cttaaaggga ccagactttc taaatcttac aactcaagag   4380

gtggcagcca ccctctagga gacaaaacta cccccactga caaggcttta ggagacccta   4440

aagtctgttg gctgtgacgt cattatacct aaaatctgca tcatacctgc aagccaacag   4500

ttcagtgttt taacagagaa ccaccctggg aaacagaagc agatctgatg tgtttcctat   4560

acatgtcctg tgctcacttt attaaaaatt cttttgcaca caatgtttat gaaaaggcca   4620

gatccttttc caatacttat gcaaaagcaa aagaaaaccc cgacacctca cctttcgctg   4680

tttgttgttt catagattta tttaaaaaaa gagaaagtct atagctataa atctttaaag   4740

agaaatatga atacaattcc cctaaactct cctcaaaaga gaattcagtc tacagccatt   4800

taaatgatca ttgctgctac agaagtgctt taagagaatt gcctgaaaca tctgtattat   4860

atcggccacc tgccaatcac agctttactc tttcaggtca ctctggggct gcctcttgca   4920

tgtattacta aataaaatga tctctctttc tctctctctc tctcttttct aagaaacaat   4980

tatgtgcact ttgatacaca accttctcta accaactata tatcaagacc caaaaattga   5040

agaaaaatat tgttttctca tacagtgagc agatttttca atctactaat tctgtgactt   5100

gtcttggtgt gctagcctac accttctctt tggtttagtt ttccttttct ataacactct   5160

gaattgctaa tcttactaac acctatgatg ttacctgaaa tcaatctccc atatgtatgc   5220

tgtatgctat gctaagactc ctgaaatata cttactctgt gcttgtgtat gtgaatgtta   5280

atgcaactat tacctagagt gaactttaag ctttattgtt gaatgtaatt ccattatatt   5340

tccttttgta cacctgtgaa aaagtggagt agtgtttttt taaccattgt taatcagctt   5400

ttgtgtatga aagacacagt aaaatttctt tcttaaatc                          5439


<210>  2183
<211>  950
<212>  PRT
<213>  Homo sapiens

<400>  2183


Met Leu Tyr Ser Ser Arg Gly Asp Pro Glu Gly Gln Pro Leu Leu Leu 
1               5                   10                  15      


Ser Leu Leu Ile Leu Ala Met Trp Val Val Gly Ser Gly Gln Leu His 
            20                  25                  30          


Tyr Ser Val Pro Glu Glu Ala Glu His Gly Thr Phe Val Gly Arg Ile 
        35                  40                  45              


Ala Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Pro Arg Leu Phe 
    50                  55                  60                  


Gln Leu Asp Ser Lys Gly Arg Gly Asp Leu Leu Glu Val Asn Leu Gln 
65                  70                  75                  80  


Asn Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Gly Arg Ser Ala Glu Cys Ser Ile His Leu Glu Val Ile Val Asp Arg 
            100                 105                 110         


Pro Leu Gln Val Phe His Val Asp Val Glu Val Lys Asp Ile Asn Asp 
        115                 120                 125             


Asn Pro Pro Val Phe Pro Ala Thr Gln Lys Asn Leu Phe Ile Ala Glu 
    130                 135                 140                 


Ser Arg Pro Leu Asp Ser Arg Phe Pro Leu Glu Gly Ala Ser Asp Ala 
145                 150                 155                 160 


Asp Ile Gly Glu Asn Ala Leu Leu Thr Tyr Arg Leu Ser Pro Asn Glu 
                165                 170                 175     


Tyr Phe Phe Leu Asp Val Pro Thr Ser Asn Gln Gln Val Lys Pro Leu 
            180                 185                 190         


Gly Leu Val Leu Arg Lys Leu Leu Asp Arg Glu Glu Thr Pro Glu Leu 
        195                 200                 205             


His Leu Leu Leu Thr Ala Thr Asp Gly Gly Lys Pro Glu Leu Thr Gly 
    210                 215                 220                 


Thr Val Gln Leu Leu Ile Thr Val Leu Asp Asn Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Val Phe Asp Arg Thr Leu Tyr Thr Val Lys Leu Pro Glu Asn Val Ser 
                245                 250                 255     


Ile Gly Thr Leu Val Ile His Pro Asn Ala Ser Asp Leu Asp Glu Gly 
            260                 265                 270         


Leu Asn Gly Asp Ile Ile Tyr Ser Phe Ser Ser Asp Val Ser Pro Asp 
        275                 280                 285             


Ile Lys Ser Lys Phe His Met Asp Pro Leu Ser Gly Ala Ile Thr Val 
    290                 295                 300                 


Ile Gly His Met Asp Phe Glu Glu Ser Arg Ala His Lys Ile Pro Val 
305                 310                 315                 320 


Glu Ala Val Asp Lys Gly Phe Pro Pro Leu Ala Gly His Cys Thr Leu 
                325                 330                 335     


Leu Val Glu Val Val Asp Val Asn Asp Asn Ala Pro Gln Leu Thr Ile 
            340                 345                 350         


Lys Thr Leu Ser Val Pro Val Lys Glu Asp Ala Gln Leu Gly Thr Val 
        355                 360                 365             


Ile Ala Leu Ile Ser Val Ile Asp Leu Asp Ala Asp Ala Asn Gly Gln 
    370                 375                 380                 


Val Thr Cys Ser Leu Thr Pro His Val Pro Phe Lys Leu Val Ser Thr 
385                 390                 395                 400 


Tyr Lys Asn Tyr Tyr Ser Leu Val Leu Asp Arg Ala Leu Asp Arg Glu 
                405                 410                 415     


Ser Val Ser Ala Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser 
            420                 425                 430         


Pro Ser Leu Trp Ala Thr Ala Arg Val Ser Val Glu Val Ala Asp Val 
        435                 440                 445             


Asn Asp Asn Ala Pro Ala Phe Ala Gln Ser Glu Tyr Thr Val Phe Val 
    450                 455                 460                 


Lys Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Arg 
465                 470                 475                 480 


Asp Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu 
                485                 490                 495     


Arg Arg Leu Gly Glu Arg Ser Leu Ser Ser Tyr Val Ser Val His Ala 
            500                 505                 510         


Glu Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu 
        515                 520                 525             


Glu Leu Leu Gln Phe Gln Val Ser Ala Arg Asp Ala Gly Val Pro Pro 
    530                 535                 540                 


Leu Gly Ser Asn Val Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp 
545                 550                 555                 560 


Asn Ala Pro Ala Leu Leu Thr Pro Arg Met Arg Gly Thr Asp Gly Ala 
                565                 570                 575     


Val Ser Glu Met Val Leu Arg Ser Val Gly Ala Gly Val Val Val Gly 
            580                 585                 590         


Lys Val Arg Ala Val Asp Ala Asp Ser Gly Tyr Asn Ala Trp Leu Ser 
        595                 600                 605             


Tyr Glu Leu Gln Pro Glu Thr Ala Ser Ala Ser Ile Pro Phe Arg Val 
    610                 615                 620                 


Gly Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Ala Leu Asp Glu Thr 
625                 630                 635                 640 


Asp Ala Pro Arg Gln Arg Leu Leu Val Leu Val Lys Asp His Gly Glu 
                645                 650                 655     


Pro Ala Leu Thr Ala Thr Ala Thr Val Leu Val Ser Leu Val Glu Ser 
            660                 665                 670         


Gly Gln Ala Pro Lys Ser Ser Ser Arg Ala Ser Val Gly Ala Thr Gly 
        675                 680                 685             


Pro Glu Val Thr Leu Val Asp Val Asn Val Tyr Leu Ile Ile Ala Ile 
    690                 695                 700                 


Cys Ala Val Ser Ser Leu Leu Val Leu Thr Leu Leu Leu Tyr Thr Val 
705                 710                 715                 720 


Leu Arg Cys Ser Ala Met Pro Thr Glu Gly Glu Cys Ala Pro Gly Lys 
                725                 730                 735     


Pro Thr Leu Val Cys Ser Ser Ala Val Gly Ser Trp Ser Tyr Ser Gln 
            740                 745                 750         


Gln Arg Arg Gln Arg Val Cys Ser Gly Glu Gly Lys Gln Lys Thr Asp 
        755                 760                 765             


Leu Met Ala Phe Ser Pro Gly Leu Ser Pro Cys Ala Gly Ser Thr Glu 
    770                 775                 780                 


Arg Thr Gly Glu Pro Ser Ala Ser Ser Asp Ser Thr Gly Lys Pro Arg 
785                 790                 795                 800 


Gln Pro Asn Pro Asp Trp Arg Tyr Ser Ala Ser Leu Arg Ala Gly Met 
                805                 810                 815     


His Ser Ser Val His Leu Glu Glu Ala Gly Ile Leu Arg Ala Gly Pro 
            820                 825                 830         


Gly Gly Pro Asp Gln Gln Trp Pro Thr Val Ser Ser Ala Thr Pro Glu 
        835                 840                 845             


Pro Glu Ala Gly Glu Val Ser Pro Pro Val Gly Ala Gly Val Asn Ser 
    850                 855                 860                 


Asn Ser Trp Thr Phe Lys Tyr Gly Pro Gly Asn Pro Lys Gln Ser Gly 
865                 870                 875                 880 


Pro Gly Glu Leu Pro Asp Lys Phe Ile Ile Pro Gly Ser Pro Ala Ile 
                885                 890                 895     


Ile Ser Ile Arg Gln Glu Pro Thr Asn Ser Gln Ile Asp Lys Ser Asp 
            900                 905                 910         


Phe Ile Thr Phe Gly Lys Lys Glu Glu Thr Lys Lys Lys Lys Lys Lys 
        915                 920                 925             


Lys Lys Gly Asn Lys Thr Gln Glu Lys Lys Glu Lys Gly Asn Ser Thr 
    930                 935                 940                 


Thr Asp Asn Ser Asp Gln 
945                 950 

<210>  2184
<211>  6207
<212>  DNA
<213>  Homo sapiens

<400>  2184
acttggacgt tggaataaga tagtaaaact cacaacaaaa ctttgtagaa cttagtcagg     60

aaaagaatct caagcatagc tttaaaaaca gaaattgccc cgagtactaa ggatgagcaa    120

taatgaaatt aaaacatatt gtaataacat tacacaaact atattggaga ctacaaagaa    180

gagattattc atagattata aagcttggaa agaatcaaaa caacacattt ctggaaacag    240

attgtataaa tgctacaaaa gagaaaaata tattttctcc ccacgcaaca caagacctta    300

aagtgattcc ttttaccaga catgactaag tttctttttc atcagtagat ttctgggctc    360

ctatattcac tagagattgc aactcctgga tttctcttac actagaatcc tatttcgagc    420

catatgggag attctgaatt ccagaacaaa agaattttgt aatttaaaat tcgtgattgc    480

tcaatggaat cattttaatt gttacttcat ttctgtcgtt atttaaaact taagtggaga    540

gttttctcag ggataagaaa accacaatca aggtcataca aaacttttag aggcagtcag    600

tctgctaaga aggctccagc aagagaaacg ggatcttctg tttcaacaat cattacttaa    660

gaaaaaatta agaaaatgaa ataagttttg cagaataact gtgaaatttt tattcatgaa    720

atatgtactt acactttggg ccacgtgatg tcactctttg ccgcgatgtt ctctctgaat    780

ccagacaaat acagcccttt tcccatggga aagaggctca attctttttc actctctctg    840

tgctgaacga tggcgaacac agcagaatgg gactgacgaa atcagatgat ttcttctaat    900

ttggaggcaa ttttcactaa ttagaagaag actgagtatt tgaaatgtta tactcaagtc    960

gaggagatcc agagggtcag cctctactgc tctcgcttct gatcctcgca atgtgggtgg   1020

tggggagcgg ccagctccac tactccgtcc cggaggaagc cgaacacggc accttcgtgg   1080

gccgcatcgc gcaggacctg gggctggagc tggcggagct ggtgccgcgc ctgttccagt   1140

tggattccaa aggccgcggg gaccttctgg aggtaaatct gcagaatggc attttgtttg   1200

tgaattctcg gatcgaccgc gaggagctgt gcgggcggag cgcggagtgc agcatccacc   1260

tggaggtgat cgtagacagg ccgctgcagg ttttccatgt ggacgtggag gtgaaggaca   1320

ttaacgacaa ccctccagtg ttcccagcga cacaaaagaa tctgttcatc gcggaatcca   1380

ggccgcttga ctctcggttt ccactagagg gcgcgtccga tgcagatatc ggggagaacg   1440

ccctgctcac ttacagactg agccccaatg agtatttctt cctggacgtg ccaaccagca   1500

accagcaggt aaaacctctt ggacttgtat tacggaaact tttagacaga gaagaaactc   1560

cggagcttca tttattgctc acggccaccg atggaggcaa acccgagctg actggcaccg   1620

ttcaattact catcacggta ctggacaaca atgacaatgc cccagtgttc gacagaaccc   1680

tgtatacggt gaaattacca gaaaacgttt ctatcggaac gctggtgatt caccccaatg   1740

cctcagattt agacgaaggc ttgaatgggg atattattta ctccttctcc agtgatgttt   1800

ctccagatat aaaatccaag ttccacatgg accccttaag tggggcaatc acagtgatag   1860

gacatatgga ttttgaagaa agtagagcac acaagatccc agtcgaggct gtcgataaag   1920

gcttcccacc cctggctggt cattgtacac ttcttgtgga agttgtggat gtaaatgaca   1980

atgctccaca gttgactatc aaaacgctct cggttcctgt aaaagaggac gcacaactgg   2040

ggacagttat tgccctgatt agtgtgatcg acctagacgc agatgccaac gggcaggtta   2100

cctgctccct gacgccccac gtccccttca agctggtgtc cacctacaag aattactact   2160

cgttggtgct ggacagagct ctggaccgcg agagtgtgtc cgcctacgag ctggtggtta   2220

ccgcgcggga cgggggctcg ccttcactgt gggccacggc cagggtgtct gtggaggtgg   2280

ccgacgtgaa cgacaacgca ccagcgttcg cgcagtccga gtacacggtg ttcgtgaagg   2340

agaacaaccc gccgggctgc cacatcttca cggtgtctgc gcgggacgct gacgcgcagg   2400

agaacgccct ggtgtcctac tcgctggtgg agcggcggtt gggcgagcgc tcgctgtcga   2460

gctacgtgtc agtgcacgcg gagagcggca aggtgtacgc gctgcagccg ttggaccacg   2520

aggagctgga gctgctacag ttccaggtga gcgcgcgcga cgcgggcgtg ccgcctctgg   2580

gcagcaacgt gacgctgcag gtgttcgtgc tggacgagaa cgacaatgcg ccggcgctgc   2640

tgacacctcg gatgaggggc actgacggcg cagtgagcga gatggtgctg cggtcggtgg   2700

gcgccggcgt agtggtgggg aaggtgcgcg cagtggacgc cgactcgggc tacaacgcgt   2760

ggctttcata cgagctgcag ccagaaacgg ccagcgcgag catcccgttc cgcgtggggc   2820

tgtacacggg cgagatcagc acaacgcgtg ccctggacga aacggacgca ccgcgccagc   2880

gcctactggt gctggtgaaa gaccacgggg agccagcgct gacggccacg gccactgtgc   2940

tggtgtcgct ggtggagagc ggccaggcgc caaagtcatc gtcgcgggcg tcagtgggtg   3000

ccacgggccc cgaggtgacg ctggtggatg tcaacgtgta cctgatcatc gccatctgcg   3060

cggtgtctag cctgttggtt ctcacgctgc tgctgtacac tgtgctgcgg tgctcggcga   3120

tgcccaccga gggcgagtgc gcgcctggca agccgacgct ggtgtgttct agcgcggtgg   3180

ggagttggtc gtactcgcag cagaggaggc agagggtgtg ctctggcgag ggtaagcaga   3240

agaccgacct catggccttc agcccgggcc tttctccttg tgctggatct acagagcgaa   3300

cgggagaacc ctctgcttcc tcagattcaa ctgggaagcc acgacagccc aaccctgact   3360

ggcgttactc tgcctccctg agagcaggca tgcacagctc tgtgcaccta gaggaggctg   3420

gcattctacg ggctggtcca ggagggcctg atcagcagtg gccaacagta tccagtgcaa   3480

caccagaacc agaggcagga gaagtgtccc ctccagtcgg tgcgggtgtc aacagcaaca   3540

gctggacctt taaatacgga ccaggcaacc ccaaacaatc cggtcccggt gagttgcccg   3600

acaaattcat tatcccagga tctcctgcaa tcatctccat ccggcaggag cctactaaca   3660

gccaaattga caaaagtgac ttcataacct tcggcaaaaa ggaggagacc aagaaaaaga   3720

agaaaaagaa gaagggtaac aagacccagg agaaaaaaga gaaagggaac agcacgactg   3780

acaacagtga ccagtgaggt cctcaaatgg aaacaagcca cttagccagt ttttgtaata   3840

atggcaaatc tctcccatgt agcaattccc tgctcctttt tcctatctac atgagccctc   3900

ttagagacct cagaaatctg cagaaagttc cctgtgtctg tctagaacgc atttaacagg   3960

ttttgtcgta aaagctttac taagtctggt gttaactctt tctctccact ctggcttgtt   4020

ttcagaacct aaaaagcaga cccaagtttc ctttctcctc cgccgcaaag gagaggcttc   4080

ccagccccgc cagtgagagg ttggactctc tgccctgtgc tccggggatc ctgtcttgat   4140

gacacttgca gggcaggctg aaaagttttg agattgagca gcttgggagt ttgtggccac   4200

tgggtatgtg tggctaccgc gggtatgcga gtgccagata ttggctgaga cgagccagct   4260

tagactaatt ggtacaagga aggcaagaaa acaaagacaa ataaacagcg gaagttatca   4320

gtatggaggg gaagtgtaaa cttaaaggga ccagactttc taaatcttac aactcaagag   4380

gtggcagcca ccctctagga gacaaaacta cccccactga caaggcttta ggagacccta   4440

aagtctgttg gctgtgacgt cattatacct aaaatctgca tcatacctgc aagccaacag   4500

ttcagtgttt taacagagaa ccaccctggg aaacagaagc agatctgatg tgtttcctat   4560

acatgtcctg tgctcacttt attaaaaatt cttttgcaca caatgtttat gaaaaggcca   4620

gatccttttc caatacttat gcaaaagcaa aagaaaaccc cgacacctca cctttcgctg   4680

tttgttgttt catagattta tttaaaaaaa gagaaagtct atagctataa atctttaaag   4740

agaaatatga atacaattcc cctaaactct cctcaaaaga gaattcagtc tacagccatt   4800

taaatgatca ttgctgctac agaagtgctt taagagaatt gcctgaaaca tctgtattat   4860

atcggccacc tgccaatcac agctttactc tttcaggtca ctctggggct gcctcttgca   4920

tgtattacta aataaaatga tctctctttc tctctctctc tctcttttct aagaaacaat   4980

tatgtgcact ttgatacaca accttctcta accaactata tatcaagacc caaaaattga   5040

agaaaaatat tgttttctca tacagtgagc agatttttca atctactaat tctgtgactt   5100

gtcttggtgt gctagcctac accttctctt tggtttagtt ttccttttct ataacactct   5160

gaattgctaa tcttactaac acctatgatg ttacctgaaa tcaatctccc atatgtatgc   5220

tgtatgctat gctaagactc ctgaaatata cttactctgt gcttgtgtat gtgaatgtta   5280

atgcaactat tacctagagt gaactttaag ctttattgtt gaatgtaatt ccattatatt   5340

tccttttgta cacctgtgaa aaagtggagt agtgtttttt taaccattgt taatcagctt   5400

ttgtgtatga aagacacagt aaaatttctt tcttaaatca agatactggt gattcaagga   5460

attttattta tggtccagcc aagagccatc tcgtgccaag acttctgctg gcaagggaat   5520

ggataaagct gttttgttct agtaacaatt ttggaatgaa tactgacaat attccatgag   5580

ggtgtgcaag cacaaatttt accaatctga cctctttgaa gttgcagaat gctttgaaat   5640

tctaatggta tctgaaatat cagctcatag aaagtaacaa aatttgctgt caccttaaat   5700

aagacatttt aattttgtta taatgtacaa tttagaagtt tgattaatta tattatctat   5760

ttaggcatta atataaaaga ggtaggagtc tgttatttaa aaaaagcatt aaatttaaaa   5820

aaaaactgtc ttgtctactt ttagcttcat tctcccatat tttgaagggt gtgtaacttc   5880

agctctgcag gattgcatgg ggtaaaactt gttaccaaca catgtgaacc attgctacat   5940

tgtaggttgt gatcattttg ccccactgaa gcccatgtat ctgaccttac gtgccttttg   6000

aactaggaga atcgggctaa tttattaatg atgataatta taatgtatct gtacagcact   6060

ttttacattt gcgaagtgct ttccaatcca tgttagttac tagttattac agctgtaagg   6120

ataaaacacg tcatgtggat tcattttgaa ttggtgctat tggtatttcc tctgttattg   6180

ctaataaatg aaaatggtgg tatgaaa                                       6207


<210>  2185
<211>  950
<212>  PRT
<213>  Homo sapiens

<400>  2185


Met Leu Tyr Ser Ser Arg Gly Asp Pro Glu Gly Gln Pro Leu Leu Leu 
1               5                   10                  15      


Ser Leu Leu Ile Leu Ala Met Trp Val Val Gly Ser Gly Gln Leu His 
            20                  25                  30          


Tyr Ser Val Pro Glu Glu Ala Glu His Gly Thr Phe Val Gly Arg Ile 
        35                  40                  45              


Ala Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Pro Arg Leu Phe 
    50                  55                  60                  


Gln Leu Asp Ser Lys Gly Arg Gly Asp Leu Leu Glu Val Asn Leu Gln 
65                  70                  75                  80  


Asn Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Gly Arg Ser Ala Glu Cys Ser Ile His Leu Glu Val Ile Val Asp Arg 
            100                 105                 110         


Pro Leu Gln Val Phe His Val Asp Val Glu Val Lys Asp Ile Asn Asp 
        115                 120                 125             


Asn Pro Pro Val Phe Pro Ala Thr Gln Lys Asn Leu Phe Ile Ala Glu 
    130                 135                 140                 


Ser Arg Pro Leu Asp Ser Arg Phe Pro Leu Glu Gly Ala Ser Asp Ala 
145                 150                 155                 160 


Asp Ile Gly Glu Asn Ala Leu Leu Thr Tyr Arg Leu Ser Pro Asn Glu 
                165                 170                 175     


Tyr Phe Phe Leu Asp Val Pro Thr Ser Asn Gln Gln Val Lys Pro Leu 
            180                 185                 190         


Gly Leu Val Leu Arg Lys Leu Leu Asp Arg Glu Glu Thr Pro Glu Leu 
        195                 200                 205             


His Leu Leu Leu Thr Ala Thr Asp Gly Gly Lys Pro Glu Leu Thr Gly 
    210                 215                 220                 


Thr Val Gln Leu Leu Ile Thr Val Leu Asp Asn Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Val Phe Asp Arg Thr Leu Tyr Thr Val Lys Leu Pro Glu Asn Val Ser 
                245                 250                 255     


Ile Gly Thr Leu Val Ile His Pro Asn Ala Ser Asp Leu Asp Glu Gly 
            260                 265                 270         


Leu Asn Gly Asp Ile Ile Tyr Ser Phe Ser Ser Asp Val Ser Pro Asp 
        275                 280                 285             


Ile Lys Ser Lys Phe His Met Asp Pro Leu Ser Gly Ala Ile Thr Val 
    290                 295                 300                 


Ile Gly His Met Asp Phe Glu Glu Ser Arg Ala His Lys Ile Pro Val 
305                 310                 315                 320 


Glu Ala Val Asp Lys Gly Phe Pro Pro Leu Ala Gly His Cys Thr Leu 
                325                 330                 335     


Leu Val Glu Val Val Asp Val Asn Asp Asn Ala Pro Gln Leu Thr Ile 
            340                 345                 350         


Lys Thr Leu Ser Val Pro Val Lys Glu Asp Ala Gln Leu Gly Thr Val 
        355                 360                 365             


Ile Ala Leu Ile Ser Val Ile Asp Leu Asp Ala Asp Ala Asn Gly Gln 
    370                 375                 380                 


Val Thr Cys Ser Leu Thr Pro His Val Pro Phe Lys Leu Val Ser Thr 
385                 390                 395                 400 


Tyr Lys Asn Tyr Tyr Ser Leu Val Leu Asp Arg Ala Leu Asp Arg Glu 
                405                 410                 415     


Ser Val Ser Ala Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser 
            420                 425                 430         


Pro Ser Leu Trp Ala Thr Ala Arg Val Ser Val Glu Val Ala Asp Val 
        435                 440                 445             


Asn Asp Asn Ala Pro Ala Phe Ala Gln Ser Glu Tyr Thr Val Phe Val 
    450                 455                 460                 


Lys Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Arg 
465                 470                 475                 480 


Asp Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu 
                485                 490                 495     


Arg Arg Leu Gly Glu Arg Ser Leu Ser Ser Tyr Val Ser Val His Ala 
            500                 505                 510         


Glu Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu 
        515                 520                 525             


Glu Leu Leu Gln Phe Gln Val Ser Ala Arg Asp Ala Gly Val Pro Pro 
    530                 535                 540                 


Leu Gly Ser Asn Val Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp 
545                 550                 555                 560 


Asn Ala Pro Ala Leu Leu Thr Pro Arg Met Arg Gly Thr Asp Gly Ala 
                565                 570                 575     


Val Ser Glu Met Val Leu Arg Ser Val Gly Ala Gly Val Val Val Gly 
            580                 585                 590         


Lys Val Arg Ala Val Asp Ala Asp Ser Gly Tyr Asn Ala Trp Leu Ser 
        595                 600                 605             


Tyr Glu Leu Gln Pro Glu Thr Ala Ser Ala Ser Ile Pro Phe Arg Val 
    610                 615                 620                 


Gly Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Ala Leu Asp Glu Thr 
625                 630                 635                 640 


Asp Ala Pro Arg Gln Arg Leu Leu Val Leu Val Lys Asp His Gly Glu 
                645                 650                 655     


Pro Ala Leu Thr Ala Thr Ala Thr Val Leu Val Ser Leu Val Glu Ser 
            660                 665                 670         


Gly Gln Ala Pro Lys Ser Ser Ser Arg Ala Ser Val Gly Ala Thr Gly 
        675                 680                 685             


Pro Glu Val Thr Leu Val Asp Val Asn Val Tyr Leu Ile Ile Ala Ile 
    690                 695                 700                 


Cys Ala Val Ser Ser Leu Leu Val Leu Thr Leu Leu Leu Tyr Thr Val 
705                 710                 715                 720 


Leu Arg Cys Ser Ala Met Pro Thr Glu Gly Glu Cys Ala Pro Gly Lys 
                725                 730                 735     


Pro Thr Leu Val Cys Ser Ser Ala Val Gly Ser Trp Ser Tyr Ser Gln 
            740                 745                 750         


Gln Arg Arg Gln Arg Val Cys Ser Gly Glu Gly Lys Gln Lys Thr Asp 
        755                 760                 765             


Leu Met Ala Phe Ser Pro Gly Leu Ser Pro Cys Ala Gly Ser Thr Glu 
    770                 775                 780                 


Arg Thr Gly Glu Pro Ser Ala Ser Ser Asp Ser Thr Gly Lys Pro Arg 
785                 790                 795                 800 


Gln Pro Asn Pro Asp Trp Arg Tyr Ser Ala Ser Leu Arg Ala Gly Met 
                805                 810                 815     


His Ser Ser Val His Leu Glu Glu Ala Gly Ile Leu Arg Ala Gly Pro 
            820                 825                 830         


Gly Gly Pro Asp Gln Gln Trp Pro Thr Val Ser Ser Ala Thr Pro Glu 
        835                 840                 845             


Pro Glu Ala Gly Glu Val Ser Pro Pro Val Gly Ala Gly Val Asn Ser 
    850                 855                 860                 


Asn Ser Trp Thr Phe Lys Tyr Gly Pro Gly Asn Pro Lys Gln Ser Gly 
865                 870                 875                 880 


Pro Gly Glu Leu Pro Asp Lys Phe Ile Ile Pro Gly Ser Pro Ala Ile 
                885                 890                 895     


Ile Ser Ile Arg Gln Glu Pro Thr Asn Ser Gln Ile Asp Lys Ser Asp 
            900                 905                 910         


Phe Ile Thr Phe Gly Lys Lys Glu Glu Thr Lys Lys Lys Lys Lys Lys 
        915                 920                 925             


Lys Lys Gly Asn Lys Thr Gln Glu Lys Lys Glu Lys Gly Asn Ser Thr 
    930                 935                 940                 


Thr Asp Asn Ser Asp Gln 
945                 950 

<210>  2186
<211>  5987
<212>  DNA
<213>  Homo sapiens

<400>  2186
ctcgcttttc ttgcaatatt ttataccttt tcaattcata gaattactca agaaaactac     60

ctcagttggt tgctactttt tgttgattcc ttttaccaga catgactaag tttctttttc    120

atcagtagat ttctgggctc ctatattcac tagagattgc aactcctgga tttctcttac    180

actagaatcc tatttcgagc catatgggag attctgaatt ccagaacaaa agaattttgt    240

aatttaaaat tcgtgattgc tcaatggaat cattttaatt gttacttcat ttctgtcgtt    300

atttaaaact taagtggaga gttttctcag ggataagaaa accacaatca aggtcataca    360

aaacttttag aggcagtcag tctgctaaga aggctccagc aagagaaacg ggatcttctg    420

tttcaacaat cattacttaa gaaaaaatta agaaaatgaa ataagttttg cagaataact    480

gtgaaatttt tattcatgaa atatgtactt acactttggg ccacgtgatg tcactctttg    540

ccgcgatgtt ctctctgaat ccagacaaat acagcccttt tcccatggga aagaggctca    600

attctttttc actctctctg tgctgaacga tggcgaacac agcagaatgg gactgacgaa    660

atcagatgat ttcttctaat ttggaggcaa ttttcactaa ttagaagaag actgagtatt    720

tgaaatgtta tactcaagtc gaggagatcc agagggtcag cctctactgc tctcgcttct    780

gatcctcgca atgtgggtgg tggggagcgg ccagctccac tactccgtcc cggaggaagc    840

cgaacacggc accttcgtgg gccgcatcgc gcaggacctg gggctggagc tggcggagct    900

ggtgccgcgc ctgttccagt tggattccaa aggccgcggg gaccttctgg aggtaaatct    960

gcagaatggc attttgtttg tgaattctcg gatcgaccgc gaggagctgt gcgggcggag   1020

cgcggagtgc agcatccacc tggaggtgat cgtagacagg ccgctgcagg ttttccatgt   1080

ggacgtggag gtgaaggaca ttaacgacaa ccctccagtg ttcccagcga cacaaaagaa   1140

tctgttcatc gcggaatcca ggccgcttga ctctcggttt ccactagagg gcgcgtccga   1200

tgcagatatc ggggagaacg ccctgctcac ttacagactg agccccaatg agtatttctt   1260

cctggacgtg ccaaccagca accagcaggt aaaacctctt ggacttgtat tacggaaact   1320

tttagacaga gaagaaactc cggagcttca tttattgctc acggccaccg atggaggcaa   1380

acccgagctg actggcaccg ttcaattact catcacggta ctggacaaca atgacaatgc   1440

cccagtgttc gacagaaccc tgtatacggt gaaattacca gaaaacgttt ctatcggaac   1500

gctggtgatt caccccaatg cctcagattt agacgaaggc ttgaatgggg atattattta   1560

ctccttctcc agtgatgttt ctccagatat aaaatccaag ttccacatgg accccttaag   1620

tggggcaatc acagtgatag gacatatgga ttttgaagaa agtagagcac acaagatccc   1680

agtcgaggct gtcgataaag gcttcccacc cctggctggt cattgtacac ttcttgtgga   1740

agttgtggat gtaaatgaca atgctccaca gttgactatc aaaacgctct cggttcctgt   1800

aaaagaggac gcacaactgg ggacagttat tgccctgatt agtgtgatcg acctagacgc   1860

agatgccaac gggcaggtta cctgctccct gacgccccac gtccccttca agctggtgtc   1920

cacctacaag aattactact cgttggtgct ggacagagct ctggaccgcg agagtgtgtc   1980

cgcctacgag ctggtggtta ccgcgcggga cgggggctcg ccttcactgt gggccacggc   2040

cagggtgtct gtggaggtgg ccgacgtgaa cgacaacgca ccagcgttcg cgcagtccga   2100

gtacacggtg ttcgtgaagg agaacaaccc gccgggctgc cacatcttca cggtgtctgc   2160

gcgggacgct gacgcgcagg agaacgccct ggtgtcctac tcgctggtgg agcggcggtt   2220

gggcgagcgc tcgctgtcga gctacgtgtc agtgcacgcg gagagcggca aggtgtacgc   2280

gctgcagccg ttggaccacg aggagctgga gctgctacag ttccaggtga gcgcgcgcga   2340

cgcgggcgtg ccgcctctgg gcagcaacgt gacgctgcag gtgttcgtgc tggacgagaa   2400

cgacaatgcg ccggcgctgc tgacacctcg gatgaggggc actgacggcg cagtgagcga   2460

gatggtgctg cggtcggtgg gcgccggcgt agtggtgggg aaggtgcgcg cagtggacgc   2520

cgactcgggc tacaacgcgt ggctttcata cgagctgcag ccagaaacgg ccagcgcgag   2580

catcccgttc cgcgtggggc tgtacacggg cgagatcagc acaacgcgtg ccctggacga   2640

aacggacgca ccgcgccagc gcctactggt gctggtgaaa gaccacgggg agccagcgct   2700

gacggccacg gccactgtgc tggtgtcgct ggtggagagc ggccaggcgc caaagtcatc   2760

gtcgcgggcg tcagtgggtg ccacgggccc cgaggtgacg ctggtggatg tcaacgtgta   2820

cctgatcatc gccatctgcg cggtgtctag cctgttggtt ctcacgctgc tgctgtacac   2880

tgtgctgcgg tgctcggcga tgcccaccga gggcgagtgc gcgcctggca agccgacgct   2940

ggtgtgttct agcgcggtgg ggagttggtc gtactcgcag cagaggaggc agagggtgtg   3000

ctctggcgag ggtaagcaga agaccgacct catggccttc agcccgggcc tttctccttg   3060

tgctggatct acagagcgaa cgggagaacc ctctgcttcc tcagattcaa ctgggaagcc   3120

acgacagccc aaccctgact ggcgttactc tgcctccctg agagcaggca tgcacagctc   3180

tgtgcaccta gaggaggctg gcattctacg ggctggtcca ggagggcctg atcagcagtg   3240

gccaacagta tccagtgcaa caccagaacc agaggcagga gaagtgtccc ctccagtcgg   3300

tgcgggtgtc aacagcaaca gctggacctt taaatacgga ccaggcaacc ccaaacaatc   3360

cggtcccggt gagttgcccg acaaattcat tatcccagga tctcctgcaa tcatctccat   3420

ccggcaggag cctactaaca gccaaattga caaaagtgac ttcataacct tcggcaaaaa   3480

ggaggagacc aagaaaaaga agaaaaagaa gaagggtaac aagacccagg agaaaaaaga   3540

gaaagggaac agcacgactg acaacagtga ccagtgaggt cctcaaatgg aaacaagcca   3600

cttagccagt ttttgtaata atggcaaatc tctcccatgt agcaattccc tgctcctttt   3660

tcctatctac atgagccctc ttagagacct cagaaatctg cagaaagttc cctgtgtctg   3720

tctagaacgc atttaacagg ttttgtcgta aaagctttac taagtctggt gttaactctt   3780

tctctccact ctggcttgtt ttcagaacct aaaaagcaga cccaagtttc ctttctcctc   3840

cgccgcaaag gagaggcttc ccagccccgc cagtgagagg ttggactctc tgccctgtgc   3900

tccggggatc ctgtcttgat gacacttgca gggcaggctg aaaagttttg agattgagca   3960

gcttgggagt ttgtggccac tgggtatgtg tggctaccgc gggtatgcga gtgccagata   4020

ttggctgaga cgagccagct tagactaatt ggtacaagga aggcaagaaa acaaagacaa   4080

ataaacagcg gaagttatca gtatggaggg gaagtgtaaa cttaaaggga ccagactttc   4140

taaatcttac aactcaagag gtggcagcca ccctctagga gacaaaacta cccccactga   4200

caaggcttta ggagacccta aagtctgttg gctgtgacgt cattatacct aaaatctgca   4260

tcatacctgc aagccaacag ttcagtgttt taacagagaa ccaccctggg aaacagaagc   4320

agatctgatg tgtttcctat acatgtcctg tgctcacttt attaaaaatt cttttgcaca   4380

caatgtttat gaaaaggcca gatccttttc caatacttat gcaaaagcaa aagaaaaccc   4440

cgacacctca cctttcgctg tttgttgttt catagattta tttaaaaaaa gagaaagtct   4500

atagctataa atctttaaag agaaatatga atacaattcc cctaaactct cctcaaaaga   4560

gaattcagtc tacagccatt taaatgatca ttgctgctac agaagtgctt taagagaatt   4620

gcctgaaaca tctgtattat atcggccacc tgccaatcac agctttactc tttcaggtca   4680

ctctggggct gcctcttgca tgtattacta aataaaatga tctctctttc tctctctctc   4740

tctcttttct aagaaacaat tatgtgcact ttgatacaca accttctcta accaactata   4800

tatcaagacc caaaaattga agaaaaatat tgttttctca tacagtgagc agatttttca   4860

atctactaat tctgtgactt gtcttggtgt gctagcctac accttctctt tggtttagtt   4920

ttccttttct ataacactct gaattgctaa tcttactaac acctatgatg ttacctgaaa   4980

tcaatctccc atatgtatgc tgtatgctat gctaagactc ctgaaatata cttactctgt   5040

gcttgtgtat gtgaatgtta atgcaactat tacctagagt gaactttaag ctttattgtt   5100

gaatgtaatt ccattatatt tccttttgta cacctgtgaa aaagtggagt agtgtttttt   5160

taaccattgt taatcagctt ttgtgtatga aagacacagt aaaatttctt tcttaaatca   5220

agatactggt gattcaagga attttattta tggtccagcc aagagccatc tcgtgccaag   5280

acttctgctg gcaagggaat ggataaagct gttttgttct agtaacaatt ttggaatgaa   5340

tactgacaat attccatgag ggtgtgcaag cacaaatttt accaatctga cctctttgaa   5400

gttgcagaat gctttgaaat tctaatggta tctgaaatat cagctcatag aaagtaacaa   5460

aatttgctgt caccttaaat aagacatttt aattttgtta taatgtacaa tttagaagtt   5520

tgattaatta tattatctat ttaggcatta atataaaaga ggtaggagtc tgttatttaa   5580

aaaaagcatt aaatttaaaa aaaaactgtc ttgtctactt ttagcttcat tctcccatat   5640

tttgaagggt gtgtaacttc agctctgcag gattgcatgg ggtaaaactt gttaccaaca   5700

catgtgaacc attgctacat tgtaggttgt gatcattttg ccccactgaa gcccatgtat   5760

ctgaccttac gtgccttttg aactaggaga atcgggctaa tttattaatg atgataatta   5820

taatgtatct gtacagcact ttttacattt gcgaagtgct ttccaatcca tgttagttac   5880

tagttattac agctgtaagg ataaaacacg tcatgtggat tcattttgaa ttggtgctat   5940

tggtatttcc tctgttattg ctaataaatg aaaatggtgg tatgaaa                 5987


<210>  2187
<211>  950
<212>  PRT
<213>  Homo sapiens

<400>  2187


Met Leu Tyr Ser Ser Arg Gly Asp Pro Glu Gly Gln Pro Leu Leu Leu 
1               5                   10                  15      


Ser Leu Leu Ile Leu Ala Met Trp Val Val Gly Ser Gly Gln Leu His 
            20                  25                  30          


Tyr Ser Val Pro Glu Glu Ala Glu His Gly Thr Phe Val Gly Arg Ile 
        35                  40                  45              


Ala Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Pro Arg Leu Phe 
    50                  55                  60                  


Gln Leu Asp Ser Lys Gly Arg Gly Asp Leu Leu Glu Val Asn Leu Gln 
65                  70                  75                  80  


Asn Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Gly Arg Ser Ala Glu Cys Ser Ile His Leu Glu Val Ile Val Asp Arg 
            100                 105                 110         


Pro Leu Gln Val Phe His Val Asp Val Glu Val Lys Asp Ile Asn Asp 
        115                 120                 125             


Asn Pro Pro Val Phe Pro Ala Thr Gln Lys Asn Leu Phe Ile Ala Glu 
    130                 135                 140                 


Ser Arg Pro Leu Asp Ser Arg Phe Pro Leu Glu Gly Ala Ser Asp Ala 
145                 150                 155                 160 


Asp Ile Gly Glu Asn Ala Leu Leu Thr Tyr Arg Leu Ser Pro Asn Glu 
                165                 170                 175     


Tyr Phe Phe Leu Asp Val Pro Thr Ser Asn Gln Gln Val Lys Pro Leu 
            180                 185                 190         


Gly Leu Val Leu Arg Lys Leu Leu Asp Arg Glu Glu Thr Pro Glu Leu 
        195                 200                 205             


His Leu Leu Leu Thr Ala Thr Asp Gly Gly Lys Pro Glu Leu Thr Gly 
    210                 215                 220                 


Thr Val Gln Leu Leu Ile Thr Val Leu Asp Asn Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Val Phe Asp Arg Thr Leu Tyr Thr Val Lys Leu Pro Glu Asn Val Ser 
                245                 250                 255     


Ile Gly Thr Leu Val Ile His Pro Asn Ala Ser Asp Leu Asp Glu Gly 
            260                 265                 270         


Leu Asn Gly Asp Ile Ile Tyr Ser Phe Ser Ser Asp Val Ser Pro Asp 
        275                 280                 285             


Ile Lys Ser Lys Phe His Met Asp Pro Leu Ser Gly Ala Ile Thr Val 
    290                 295                 300                 


Ile Gly His Met Asp Phe Glu Glu Ser Arg Ala His Lys Ile Pro Val 
305                 310                 315                 320 


Glu Ala Val Asp Lys Gly Phe Pro Pro Leu Ala Gly His Cys Thr Leu 
                325                 330                 335     


Leu Val Glu Val Val Asp Val Asn Asp Asn Ala Pro Gln Leu Thr Ile 
            340                 345                 350         


Lys Thr Leu Ser Val Pro Val Lys Glu Asp Ala Gln Leu Gly Thr Val 
        355                 360                 365             


Ile Ala Leu Ile Ser Val Ile Asp Leu Asp Ala Asp Ala Asn Gly Gln 
    370                 375                 380                 


Val Thr Cys Ser Leu Thr Pro His Val Pro Phe Lys Leu Val Ser Thr 
385                 390                 395                 400 


Tyr Lys Asn Tyr Tyr Ser Leu Val Leu Asp Arg Ala Leu Asp Arg Glu 
                405                 410                 415     


Ser Val Ser Ala Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser 
            420                 425                 430         


Pro Ser Leu Trp Ala Thr Ala Arg Val Ser Val Glu Val Ala Asp Val 
        435                 440                 445             


Asn Asp Asn Ala Pro Ala Phe Ala Gln Ser Glu Tyr Thr Val Phe Val 
    450                 455                 460                 


Lys Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Arg 
465                 470                 475                 480 


Asp Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu 
                485                 490                 495     


Arg Arg Leu Gly Glu Arg Ser Leu Ser Ser Tyr Val Ser Val His Ala 
            500                 505                 510         


Glu Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu 
        515                 520                 525             


Glu Leu Leu Gln Phe Gln Val Ser Ala Arg Asp Ala Gly Val Pro Pro 
    530                 535                 540                 


Leu Gly Ser Asn Val Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp 
545                 550                 555                 560 


Asn Ala Pro Ala Leu Leu Thr Pro Arg Met Arg Gly Thr Asp Gly Ala 
                565                 570                 575     


Val Ser Glu Met Val Leu Arg Ser Val Gly Ala Gly Val Val Val Gly 
            580                 585                 590         


Lys Val Arg Ala Val Asp Ala Asp Ser Gly Tyr Asn Ala Trp Leu Ser 
        595                 600                 605             


Tyr Glu Leu Gln Pro Glu Thr Ala Ser Ala Ser Ile Pro Phe Arg Val 
    610                 615                 620                 


Gly Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Ala Leu Asp Glu Thr 
625                 630                 635                 640 


Asp Ala Pro Arg Gln Arg Leu Leu Val Leu Val Lys Asp His Gly Glu 
                645                 650                 655     


Pro Ala Leu Thr Ala Thr Ala Thr Val Leu Val Ser Leu Val Glu Ser 
            660                 665                 670         


Gly Gln Ala Pro Lys Ser Ser Ser Arg Ala Ser Val Gly Ala Thr Gly 
        675                 680                 685             


Pro Glu Val Thr Leu Val Asp Val Asn Val Tyr Leu Ile Ile Ala Ile 
    690                 695                 700                 


Cys Ala Val Ser Ser Leu Leu Val Leu Thr Leu Leu Leu Tyr Thr Val 
705                 710                 715                 720 


Leu Arg Cys Ser Ala Met Pro Thr Glu Gly Glu Cys Ala Pro Gly Lys 
                725                 730                 735     


Pro Thr Leu Val Cys Ser Ser Ala Val Gly Ser Trp Ser Tyr Ser Gln 
            740                 745                 750         


Gln Arg Arg Gln Arg Val Cys Ser Gly Glu Gly Lys Gln Lys Thr Asp 
        755                 760                 765             


Leu Met Ala Phe Ser Pro Gly Leu Ser Pro Cys Ala Gly Ser Thr Glu 
    770                 775                 780                 


Arg Thr Gly Glu Pro Ser Ala Ser Ser Asp Ser Thr Gly Lys Pro Arg 
785                 790                 795                 800 


Gln Pro Asn Pro Asp Trp Arg Tyr Ser Ala Ser Leu Arg Ala Gly Met 
                805                 810                 815     


His Ser Ser Val His Leu Glu Glu Ala Gly Ile Leu Arg Ala Gly Pro 
            820                 825                 830         


Gly Gly Pro Asp Gln Gln Trp Pro Thr Val Ser Ser Ala Thr Pro Glu 
        835                 840                 845             


Pro Glu Ala Gly Glu Val Ser Pro Pro Val Gly Ala Gly Val Asn Ser 
    850                 855                 860                 


Asn Ser Trp Thr Phe Lys Tyr Gly Pro Gly Asn Pro Lys Gln Ser Gly 
865                 870                 875                 880 


Pro Gly Glu Leu Pro Asp Lys Phe Ile Ile Pro Gly Ser Pro Ala Ile 
                885                 890                 895     


Ile Ser Ile Arg Gln Glu Pro Thr Asn Ser Gln Ile Asp Lys Ser Asp 
            900                 905                 910         


Phe Ile Thr Phe Gly Lys Lys Glu Glu Thr Lys Lys Lys Lys Lys Lys 
        915                 920                 925             


Lys Lys Gly Asn Lys Thr Gln Glu Lys Lys Glu Lys Gly Asn Ser Thr 
    930                 935                 940                 


Thr Asp Asn Ser Asp Gln 
945                 950 

<210>  2188
<211>  3866
<212>  DNA
<213>  Homo sapiens

<400>  2188
agaacaaagg catcagccag tttctcaagg actaggaagt agcgtcattc tgagatctca     60

gccatttcga taaaaaatag atataagaaa taggacagaa aatgtcagat cgtatgtgcg    120

ttctagaccg ctgattcgtc gatttgtaaa acaagagaag gataagatgg tttccagatg    180

tagctgcctg ggggtccagt gtctgctgct ctcgcttctt ctcctcgcag cctgggaggt    240

ggggagcggc cagctccact actcagtcta cgaggaggcc agacacggca ccttcgtggg    300

ccgcatcgcg caggacctgg ggctggagct ggcggagctg gtgcagcgcc tgttccgggt    360

ggcgtccaaa agacacgggg accttctgga ggtaaatctg cagaatggca ttttgtttgt    420

gaattctcgg attgaccgcg aggagctgtg cgggcggagc gtggagtgca gcatccacct    480

ggaggtgatc gtggacaggc cgctgcaggt tttccatgtg gacgtggaag tgaaggacat    540

taacgacaac ccgcccaggt tctccgtaac agaacaaaag ctctcaatac ctgaatccag    600

actgcttgac tctcgatttc cactagaagg cgcatctgat gcggatgttg gagagaacgc    660

attgcttact tacaaactca gtccaaatga gtattttgtt cttgatatta taaacaaaaa    720

agacaaagac aaattcccag tgcttgttct gcggaagctg ctggatcgtg aagaaaatcc    780

tcagctaaag ttgttgttga cagcaactga tggaggcaaa cctgaattta ccggatctgt    840

ttctctgctg atcctggtgt tagatgccaa tgataacgcc cctatctttg acagaccggt    900

ttatgaagtt aagatgtatg aaaatcaagt gaaccaaaca ttagtaatac ggctcaacgc    960

ttctgattcg gatgaaggaa taaacaagga aatgatgtat tcatttagct ctttggtccc   1020

acccacgata agaaggaaat tttggataaa cgaaaggacg ggagaaataa aagtaaatga   1080

tgctattgac tttgaggaca gtaacactta tgaaattcat gtagatgtta cagataaggg   1140

aaacccacct atggttggtc actgcacggt cctagtggaa ctactggatg aaaatgataa   1200

ttcacctgag gtgattgtca cttctctgtc tctcccagtg aaagaagatg ctcaagtggg   1260

caccgtcatt gccctaatca gcgtttctga ccatgattca ggagccaacg gacaggtcac   1320

ctgctctctg acgcctcacg ttccgttcaa gctggtgtcc acctacaaga attactactc   1380

attggtgctg gacagcgctc tggaccgcga gagggtgtcg gcctatgagc tggtggtgac   1440

cgcgcgggac gggggctcgc ctccgctgtg ggccacggcc agcgtgtctg tggaggtggc   1500

cgacgtgaac gacaacgcgc ctgcgttcgc gcagtccgag tacacggtgt tcgtgaagga   1560

gaacaacccg ccaggctgcc acatcttcac ggtgtctgcg tgggacgcgg acgcgcagga   1620

gaacgccctg gtgtcctact ctctggtgga gcggcggttg ggcgagcgct cgctgtcgag   1680

ctacgtgtcg gtgcacgcgg agagcggcaa ggtgtacgcg ctgcagccgc tggaccacga   1740

ggagctggag ctgctacagt tccagccacg acagcccaac cctgactggc gttactctgc   1800

ctccctgaga gcaggcatgc acagctctgt gcacctagag gaggctggca ttctacgggc   1860

tggtccagga gggcctgatc agcagtggcc aacagtatcc agtgcaacac cagaaccaga   1920

ggcaggagaa gtgtcccctc cagtcggtgc gggtgtcaac agcaacagct ggacctttaa   1980

atacggacca ggcaacccca aacaatccgg tcccggtgag ttgcccgaca aattcattat   2040

cccaggatct cctgcaatca tctccatccg gcaggagcct actaacagcc aaattgacaa   2100

aagtgacttc ataaccttcg gcaaaaagga ggagaccaag aaaaagaaga aaaagaagaa   2160

gggtaacaag acccaggaga aaaaagagaa agggaacagc acgactgaca acagtgacca   2220

gtgaggtcct caaatggaaa caagccactt agccagtttt tgtaataatg gcaaatctct   2280

cccatgtagc aattccctgc tcctttttcc tatctacatg agccctctta gagacctcag   2340

aaatctgcag aaagttccct gtgtctgtct agaacgcatt taacaggttt tgtcgtaaaa   2400

gctttactaa gtctggtgtt aactctttct ctccactctg gcttgttttc agaacctaaa   2460

aagcagaccc aagtttcctt tctcctccgc cgcaaaggag aggcttccca gccccgccag   2520

tgagaggttg gactctctgc cctgtgctcc ggggatcctg tcttgatgac acttgcaggg   2580

caggctgaaa agttttgaga ttgagcagct tgggagtttg tggccactgg gtatgtgtgg   2640

ctaccgcggg tatgcgagtg ccagatattg gctgagacga gccagcttag actaattggt   2700

acaaggaagg caagaaaaca aagacaaata aacagcggaa gttatcagta tggaggggaa   2760

gtgtaaactt aaagggacca gactttctaa atcttacaac tcaagaggtg gcagccaccc   2820

tctaggagac aaaactaccc ccactgacaa ggctttagga gaccctaaag tctgttggct   2880

gtgacgtcat tatacctaaa atctgcatca tacctgcaag ccaacagttc agtgttttaa   2940

cagagaacca ccctgggaaa cagaagcaga tctgatgtgt ttcctataca tgtcctgtgc   3000

tcactttatt aaaaattctt ttgcacacaa tgtttatgaa aaggccagat ccttttccaa   3060

tacttatgca aaagcaaaag aaaaccccga cacctcacct ttcgctgttt gttgtttcat   3120

agatttattt aaaaaaagag aaagtctata gctataaatc tttaaagaga aatatgaata   3180

caattcccct aaactctcct caaaagagaa ttcagtctac agccatttaa atgatcattg   3240

ctgctacaga agtgctttaa gagaattgcc tgaaacatct gtattatatc ggccacctgc   3300

caatcacagc tttactcttt caggtcactc tggggctgcc tcttgcatgt attactaaat   3360

aaaatgatct ctctttctct ctctctctct cttttctaag aaacaattat gtgcactttg   3420

atacacaacc ttctctaacc aactatatat caagacccaa aaattgaaga aaaatattgt   3480

tttctcatac agtgagcaga tttttcaatc tactaattct gtgacttgtc ttggtgtgct   3540

agcctacacc ttctctttgg tttagttttc cttttctata acactctgaa ttgctaatct   3600

tactaacacc tatgatgtta cctgaaatca atctcccata tgtatgctgt atgctatgct   3660

aagactcctg aaatatactt actctgtgct tgtgtatgtg aatgttaatg caactattac   3720

ctagagtgaa ctttaagctt tattgttgaa tgtaattcca ttatatttcc ttttgtacac   3780

ctgtgaaaaa gtggagtagt gtttttttaa ccattgttaa tcagcttttg tgtatgaaag   3840

acacagtaaa atttctttct taaatc                                        3866


<210>  2189
<211>  685
<212>  PRT
<213>  Homo sapiens

<400>  2189


Met Val Ser Arg Cys Ser Cys Leu Gly Val Gln Cys Leu Leu Leu Ser 
1               5                   10                  15      


Leu Leu Leu Leu Ala Ala Trp Glu Val Gly Ser Gly Gln Leu His Tyr 
            20                  25                  30          


Ser Val Tyr Glu Glu Ala Arg His Gly Thr Phe Val Gly Arg Ile Ala 
        35                  40                  45              


Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Gln Arg Leu Phe Arg 
    50                  55                  60                  


Val Ala Ser Lys Arg His Gly Asp Leu Leu Glu Val Asn Leu Gln Asn 
65                  70                  75                  80  


Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys Gly 
                85                  90                  95      


Arg Ser Val Glu Cys Ser Ile His Leu Glu Val Ile Val Asp Arg Pro 
            100                 105                 110         


Leu Gln Val Phe His Val Asp Val Glu Val Lys Asp Ile Asn Asp Asn 
        115                 120                 125             


Pro Pro Arg Phe Ser Val Thr Glu Gln Lys Leu Ser Ile Pro Glu Ser 
    130                 135                 140                 


Arg Leu Leu Asp Ser Arg Phe Pro Leu Glu Gly Ala Ser Asp Ala Asp 
145                 150                 155                 160 


Val Gly Glu Asn Ala Leu Leu Thr Tyr Lys Leu Ser Pro Asn Glu Tyr 
                165                 170                 175     


Phe Val Leu Asp Ile Ile Asn Lys Lys Asp Lys Asp Lys Phe Pro Val 
            180                 185                 190         


Leu Val Leu Arg Lys Leu Leu Asp Arg Glu Glu Asn Pro Gln Leu Lys 
        195                 200                 205             


Leu Leu Leu Thr Ala Thr Asp Gly Gly Lys Pro Glu Phe Thr Gly Ser 
    210                 215                 220                 


Val Ser Leu Leu Ile Leu Val Leu Asp Ala Asn Asp Asn Ala Pro Ile 
225                 230                 235                 240 


Phe Asp Arg Pro Val Tyr Glu Val Lys Met Tyr Glu Asn Gln Val Asn 
                245                 250                 255     


Gln Thr Leu Val Ile Arg Leu Asn Ala Ser Asp Ser Asp Glu Gly Ile 
            260                 265                 270         


Asn Lys Glu Met Met Tyr Ser Phe Ser Ser Leu Val Pro Pro Thr Ile 
        275                 280                 285             


Arg Arg Lys Phe Trp Ile Asn Glu Arg Thr Gly Glu Ile Lys Val Asn 
    290                 295                 300                 


Asp Ala Ile Asp Phe Glu Asp Ser Asn Thr Tyr Glu Ile His Val Asp 
305                 310                 315                 320 


Val Thr Asp Lys Gly Asn Pro Pro Met Val Gly His Cys Thr Val Leu 
                325                 330                 335     


Val Glu Leu Leu Asp Glu Asn Asp Asn Ser Pro Glu Val Ile Val Thr 
            340                 345                 350         


Ser Leu Ser Leu Pro Val Lys Glu Asp Ala Gln Val Gly Thr Val Ile 
        355                 360                 365             


Ala Leu Ile Ser Val Ser Asp His Asp Ser Gly Ala Asn Gly Gln Val 
    370                 375                 380                 


Thr Cys Ser Leu Thr Pro His Val Pro Phe Lys Leu Val Ser Thr Tyr 
385                 390                 395                 400 


Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu Arg 
                405                 410                 415     


Val Ser Ala Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser Pro 
            420                 425                 430         


Pro Leu Trp Ala Thr Ala Ser Val Ser Val Glu Val Ala Asp Val Asn 
        435                 440                 445             


Asp Asn Ala Pro Ala Phe Ala Gln Ser Glu Tyr Thr Val Phe Val Lys 
    450                 455                 460                 


Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Trp Asp 
465                 470                 475                 480 


Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu Arg 
                485                 490                 495     


Arg Leu Gly Glu Arg Ser Leu Ser Ser Tyr Val Ser Val His Ala Glu 
            500                 505                 510         


Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu Glu 
        515                 520                 525             


Leu Leu Gln Phe Gln Pro Arg Gln Pro Asn Pro Asp Trp Arg Tyr Ser 
    530                 535                 540                 


Ala Ser Leu Arg Ala Gly Met His Ser Ser Val His Leu Glu Glu Ala 
545                 550                 555                 560 


Gly Ile Leu Arg Ala Gly Pro Gly Gly Pro Asp Gln Gln Trp Pro Thr 
                565                 570                 575     


Val Ser Ser Ala Thr Pro Glu Pro Glu Ala Gly Glu Val Ser Pro Pro 
            580                 585                 590         


Val Gly Ala Gly Val Asn Ser Asn Ser Trp Thr Phe Lys Tyr Gly Pro 
        595                 600                 605             


Gly Asn Pro Lys Gln Ser Gly Pro Gly Glu Leu Pro Asp Lys Phe Ile 
    610                 615                 620                 


Ile Pro Gly Ser Pro Ala Ile Ile Ser Ile Arg Gln Glu Pro Thr Asn 
625                 630                 635                 640 


Ser Gln Ile Asp Lys Ser Asp Phe Ile Thr Phe Gly Lys Lys Glu Glu 
                645                 650                 655     


Thr Lys Lys Lys Lys Lys Lys Lys Lys Gly Asn Lys Thr Gln Glu Lys 
            660                 665                 670         


Lys Glu Lys Gly Asn Ser Thr Thr Asp Asn Ser Asp Gln 
        675                 680                 685 

<210>  2190
<211>  4634
<212>  DNA
<213>  Homo sapiens

<400>  2190
agaacaaagg catcagccag tttctcaagg actaggaagt agcgtcattc tgagatctca     60

gccatttcga taaaaaatag atataagaaa taggacagaa aatgtcagat cgtatgtgcg    120

ttctagaccg ctgattcgtc gatttgtaaa acaagagaag gataagatgg tttccagatg    180

tagctgcctg ggggtccagt gtctgctgct ctcgcttctt ctcctcgcag cctgggaggt    240

ggggagcggc cagctccact actcagtcta cgaggaggcc agacacggca ccttcgtggg    300

ccgcatcgcg caggacctgg ggctggagct ggcggagctg gtgcagcgcc tgttccgggt    360

ggcgtccaaa agacacgggg accttctgga ggtaaatctg cagaatggca ttttgtttgt    420

gaattctcgg attgaccgcg aggagctgtg cgggcggagc gtggagtgca gcatccacct    480

ggaggtgatc gtggacaggc cgctgcaggt tttccatgtg gacgtggaag tgaaggacat    540

taacgacaac ccgcccaggt tctccgtaac agaacaaaag ctctcaatac ctgaatccag    600

actgcttgac tctcgatttc cactagaagg cgcatctgat gcggatgttg gagagaacgc    660

attgcttact tacaaactca gtccaaatga gtattttgtt cttgatatta taaacaaaaa    720

agacaaagac aaattcccag tgcttgttct gcggaagctg ctggatcgtg aagaaaatcc    780

tcagctaaag ttgttgttga cagcaactga tggaggcaaa cctgaattta ccggatctgt    840

ttctctgctg atcctggtgt tagatgccaa tgataacgcc cctatctttg acagaccggt    900

ttatgaagtt aagatgtatg aaaatcaagt gaaccaaaca ttagtaatac ggctcaacgc    960

ttctgattcg gatgaaggaa taaacaagga aatgatgtat tcatttagct ctttggtccc   1020

acccacgata agaaggaaat tttggataaa cgaaaggacg ggagaaataa aagtaaatga   1080

tgctattgac tttgaggaca gtaacactta tgaaattcat gtagatgtta cagataaggg   1140

aaacccacct atggttggtc actgcacggt cctagtggaa ctactggatg aaaatgataa   1200

ttcacctgag gtgattgtca cttctctgtc tctcccagtg aaagaagatg ctcaagtggg   1260

caccgtcatt gccctaatca gcgtttctga ccatgattca ggagccaacg gacaggtcac   1320

ctgctctctg acgcctcacg ttccgttcaa gctggtgtcc acctacaaga attactactc   1380

attggtgctg gacagcgctc tggaccgcga gagggtgtcg gcctatgagc tggtggtgac   1440

cgcgcgggac gggggctcgc ctccgctgtg ggccacggcc agcgtgtctg tggaggtggc   1500

cgacgtgaac gacaacgcgc ctgcgttcgc gcagtccgag tacacggtgt tcgtgaagga   1560

gaacaacccg ccaggctgcc acatcttcac ggtgtctgcg tgggacgcgg acgcgcagga   1620

gaacgccctg gtgtcctact ctctggtgga gcggcggttg ggcgagcgct cgctgtcgag   1680

ctacgtgtcg gtgcacgcgg agagcggcaa ggtgtacgcg ctgcagccgc tggaccacga   1740

ggagctggag ctgctacagt tccagccacg acagcccaac cctgactggc gttactctgc   1800

ctccctgaga gcaggcatgc acagctctgt gcacctagag gaggctggca ttctacgggc   1860

tggtccagga gggcctgatc agcagtggcc aacagtatcc agtgcaacac cagaaccaga   1920

ggcaggagaa gtgtcccctc cagtcggtgc gggtgtcaac agcaacagct ggacctttaa   1980

atacggacca ggcaacccca aacaatccgg tcccggtgag ttgcccgaca aattcattat   2040

cccaggatct cctgcaatca tctccatccg gcaggagcct actaacagcc aaattgacaa   2100

aagtgacttc ataaccttcg gcaaaaagga ggagaccaag aaaaagaaga aaaagaagaa   2160

gggtaacaag acccaggaga aaaaagagaa agggaacagc acgactgaca acagtgacca   2220

gtgaggtcct caaatggaaa caagccactt agccagtttt tgtaataatg gcaaatctct   2280

cccatgtagc aattccctgc tcctttttcc tatctacatg agccctctta gagacctcag   2340

aaatctgcag aaagttccct gtgtctgtct agaacgcatt taacaggttt tgtcgtaaaa   2400

gctttactaa gtctggtgtt aactctttct ctccactctg gcttgttttc agaacctaaa   2460

aagcagaccc aagtttcctt tctcctccgc cgcaaaggag aggcttccca gccccgccag   2520

tgagaggttg gactctctgc cctgtgctcc ggggatcctg tcttgatgac acttgcaggg   2580

caggctgaaa agttttgaga ttgagcagct tgggagtttg tggccactgg gtatgtgtgg   2640

ctaccgcggg tatgcgagtg ccagatattg gctgagacga gccagcttag actaattggt   2700

acaaggaagg caagaaaaca aagacaaata aacagcggaa gttatcagta tggaggggaa   2760

gtgtaaactt aaagggacca gactttctaa atcttacaac tcaagaggtg gcagccaccc   2820

tctaggagac aaaactaccc ccactgacaa ggctttagga gaccctaaag tctgttggct   2880

gtgacgtcat tatacctaaa atctgcatca tacctgcaag ccaacagttc agtgttttaa   2940

cagagaacca ccctgggaaa cagaagcaga tctgatgtgt ttcctataca tgtcctgtgc   3000

tcactttatt aaaaattctt ttgcacacaa tgtttatgaa aaggccagat ccttttccaa   3060

tacttatgca aaagcaaaag aaaaccccga cacctcacct ttcgctgttt gttgtttcat   3120

agatttattt aaaaaaagag aaagtctata gctataaatc tttaaagaga aatatgaata   3180

caattcccct aaactctcct caaaagagaa ttcagtctac agccatttaa atgatcattg   3240

ctgctacaga agtgctttaa gagaattgcc tgaaacatct gtattatatc ggccacctgc   3300

caatcacagc tttactcttt caggtcactc tggggctgcc tcttgcatgt attactaaat   3360

aaaatgatct ctctttctct ctctctctct cttttctaag aaacaattat gtgcactttg   3420

atacacaacc ttctctaacc aactatatat caagacccaa aaattgaaga aaaatattgt   3480

tttctcatac agtgagcaga tttttcaatc tactaattct gtgacttgtc ttggtgtgct   3540

agcctacacc ttctctttgg tttagttttc cttttctata acactctgaa ttgctaatct   3600

tactaacacc tatgatgtta cctgaaatca atctcccata tgtatgctgt atgctatgct   3660

aagactcctg aaatatactt actctgtgct tgtgtatgtg aatgttaatg caactattac   3720

ctagagtgaa ctttaagctt tattgttgaa tgtaattcca ttatatttcc ttttgtacac   3780

ctgtgaaaaa gtggagtagt gtttttttaa ccattgttaa tcagcttttg tgtatgaaag   3840

acacagtaaa atttctttct taaatcaaga tactggtgat tcaaggaatt ttatttatgg   3900

tccagccaag agccatctcg tgccaagact tctgctggca agggaatgga taaagctgtt   3960

ttgttctagt aacaattttg gaatgaatac tgacaatatt ccatgagggt gtgcaagcac   4020

aaattttacc aatctgacct ctttgaagtt gcagaatgct ttgaaattct aatggtatct   4080

gaaatatcag ctcatagaaa gtaacaaaat ttgctgtcac cttaaataag acattttaat   4140

tttgttataa tgtacaattt agaagtttga ttaattatat tatctattta ggcattaata   4200

taaaagaggt aggagtctgt tatttaaaaa aagcattaaa tttaaaaaaa aactgtcttg   4260

tctactttta gcttcattct cccatatttt gaagggtgtg taacttcagc tctgcaggat   4320

tgcatggggt aaaacttgtt accaacacat gtgaaccatt gctacattgt aggttgtgat   4380

cattttgccc cactgaagcc catgtatctg accttacgtg ccttttgaac taggagaatc   4440

gggctaattt attaatgatg ataattataa tgtatctgta cagcactttt tacatttgcg   4500

aagtgctttc caatccatgt tagttactag ttattacagc tgtaaggata aaacacgtca   4560

tgtggattca ttttgaattg gtgctattgg tatttcctct gttattgcta ataaatgaaa   4620

atggtggtat gaaa                                                     4634


<210>  2191
<211>  685
<212>  PRT
<213>  Homo sapiens

<400>  2191


Met Val Ser Arg Cys Ser Cys Leu Gly Val Gln Cys Leu Leu Leu Ser 
1               5                   10                  15      


Leu Leu Leu Leu Ala Ala Trp Glu Val Gly Ser Gly Gln Leu His Tyr 
            20                  25                  30          


Ser Val Tyr Glu Glu Ala Arg His Gly Thr Phe Val Gly Arg Ile Ala 
        35                  40                  45              


Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Gln Arg Leu Phe Arg 
    50                  55                  60                  


Val Ala Ser Lys Arg His Gly Asp Leu Leu Glu Val Asn Leu Gln Asn 
65                  70                  75                  80  


Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys Gly 
                85                  90                  95      


Arg Ser Val Glu Cys Ser Ile His Leu Glu Val Ile Val Asp Arg Pro 
            100                 105                 110         


Leu Gln Val Phe His Val Asp Val Glu Val Lys Asp Ile Asn Asp Asn 
        115                 120                 125             


Pro Pro Arg Phe Ser Val Thr Glu Gln Lys Leu Ser Ile Pro Glu Ser 
    130                 135                 140                 


Arg Leu Leu Asp Ser Arg Phe Pro Leu Glu Gly Ala Ser Asp Ala Asp 
145                 150                 155                 160 


Val Gly Glu Asn Ala Leu Leu Thr Tyr Lys Leu Ser Pro Asn Glu Tyr 
                165                 170                 175     


Phe Val Leu Asp Ile Ile Asn Lys Lys Asp Lys Asp Lys Phe Pro Val 
            180                 185                 190         


Leu Val Leu Arg Lys Leu Leu Asp Arg Glu Glu Asn Pro Gln Leu Lys 
        195                 200                 205             


Leu Leu Leu Thr Ala Thr Asp Gly Gly Lys Pro Glu Phe Thr Gly Ser 
    210                 215                 220                 


Val Ser Leu Leu Ile Leu Val Leu Asp Ala Asn Asp Asn Ala Pro Ile 
225                 230                 235                 240 


Phe Asp Arg Pro Val Tyr Glu Val Lys Met Tyr Glu Asn Gln Val Asn 
                245                 250                 255     


Gln Thr Leu Val Ile Arg Leu Asn Ala Ser Asp Ser Asp Glu Gly Ile 
            260                 265                 270         


Asn Lys Glu Met Met Tyr Ser Phe Ser Ser Leu Val Pro Pro Thr Ile 
        275                 280                 285             


Arg Arg Lys Phe Trp Ile Asn Glu Arg Thr Gly Glu Ile Lys Val Asn 
    290                 295                 300                 


Asp Ala Ile Asp Phe Glu Asp Ser Asn Thr Tyr Glu Ile His Val Asp 
305                 310                 315                 320 


Val Thr Asp Lys Gly Asn Pro Pro Met Val Gly His Cys Thr Val Leu 
                325                 330                 335     


Val Glu Leu Leu Asp Glu Asn Asp Asn Ser Pro Glu Val Ile Val Thr 
            340                 345                 350         


Ser Leu Ser Leu Pro Val Lys Glu Asp Ala Gln Val Gly Thr Val Ile 
        355                 360                 365             


Ala Leu Ile Ser Val Ser Asp His Asp Ser Gly Ala Asn Gly Gln Val 
    370                 375                 380                 


Thr Cys Ser Leu Thr Pro His Val Pro Phe Lys Leu Val Ser Thr Tyr 
385                 390                 395                 400 


Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu Arg 
                405                 410                 415     


Val Ser Ala Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser Pro 
            420                 425                 430         


Pro Leu Trp Ala Thr Ala Ser Val Ser Val Glu Val Ala Asp Val Asn 
        435                 440                 445             


Asp Asn Ala Pro Ala Phe Ala Gln Ser Glu Tyr Thr Val Phe Val Lys 
    450                 455                 460                 


Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Trp Asp 
465                 470                 475                 480 


Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu Arg 
                485                 490                 495     


Arg Leu Gly Glu Arg Ser Leu Ser Ser Tyr Val Ser Val His Ala Glu 
            500                 505                 510         


Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu Glu 
        515                 520                 525             


Leu Leu Gln Phe Gln Pro Arg Gln Pro Asn Pro Asp Trp Arg Tyr Ser 
    530                 535                 540                 


Ala Ser Leu Arg Ala Gly Met His Ser Ser Val His Leu Glu Glu Ala 
545                 550                 555                 560 


Gly Ile Leu Arg Ala Gly Pro Gly Gly Pro Asp Gln Gln Trp Pro Thr 
                565                 570                 575     


Val Ser Ser Ala Thr Pro Glu Pro Glu Ala Gly Glu Val Ser Pro Pro 
            580                 585                 590         


Val Gly Ala Gly Val Asn Ser Asn Ser Trp Thr Phe Lys Tyr Gly Pro 
        595                 600                 605             


Gly Asn Pro Lys Gln Ser Gly Pro Gly Glu Leu Pro Asp Lys Phe Ile 
    610                 615                 620                 


Ile Pro Gly Ser Pro Ala Ile Ile Ser Ile Arg Gln Glu Pro Thr Asn 
625                 630                 635                 640 


Ser Gln Ile Asp Lys Ser Asp Phe Ile Thr Phe Gly Lys Lys Glu Glu 
                645                 650                 655     


Thr Lys Lys Lys Lys Lys Lys Lys Lys Gly Asn Lys Thr Gln Glu Lys 
            660                 665                 670         


Lys Glu Lys Gly Asn Ser Thr Thr Asp Asn Ser Asp Gln 
        675                 680                 685 

<210>  2192
<211>  5423
<212>  DNA
<213>  Homo sapiens

<400>  2192
agaacaaagg catcagccag tttctcaagg actaggaagt agcgtcattc tgagatctca     60

gccatttcga taaaaaatag atataagaaa taggacagaa aatgtcagat cgtatgtgcg    120

ttctagaccg ctgattcgtc gatttgtaaa acaagagaag gataagatgg tttccagatg    180

tagctgcctg ggggtccagt gtctgctgct ctcgcttctt ctcctcgcag cctgggaggt    240

ggggagcggc cagctccact actcagtcta cgaggaggcc agacacggca ccttcgtggg    300

ccgcatcgcg caggacctgg ggctggagct ggcggagctg gtgcagcgcc tgttccgggt    360

ggcgtccaaa agacacgggg accttctgga ggtaaatctg cagaatggca ttttgtttgt    420

gaattctcgg attgaccgcg aggagctgtg cgggcggagc gtggagtgca gcatccacct    480

ggaggtgatc gtggacaggc cgctgcaggt tttccatgtg gacgtggaag tgaaggacat    540

taacgacaac ccgcccaggt tctccgtaac agaacaaaag ctctcaatac ctgaatccag    600

actgcttgac tctcgatttc cactagaagg cgcatctgat gcggatgttg gagagaacgc    660

attgcttact tacaaactca gtccaaatga gtattttgtt cttgatatta taaacaaaaa    720

agacaaagac aaattcccag tgcttgttct gcggaagctg ctggatcgtg aagaaaatcc    780

tcagctaaag ttgttgttga cagcaactga tggaggcaaa cctgaattta ccggatctgt    840

ttctctgctg atcctggtgt tagatgccaa tgataacgcc cctatctttg acagaccggt    900

ttatgaagtt aagatgtatg aaaatcaagt gaaccaaaca ttagtaatac ggctcaacgc    960

ttctgattcg gatgaaggaa taaacaagga aatgatgtat tcatttagct ctttggtccc   1020

acccacgata agaaggaaat tttggataaa cgaaaggacg ggagaaataa aagtaaatga   1080

tgctattgac tttgaggaca gtaacactta tgaaattcat gtagatgtta cagataaggg   1140

aaacccacct atggttggtc actgcacggt cctagtggaa ctactggatg aaaatgataa   1200

ttcacctgag gtgattgtca cttctctgtc tctcccagtg aaagaagatg ctcaagtggg   1260

caccgtcatt gccctaatca gcgtttctga ccatgattca ggagccaacg gacaggtcac   1320

ctgctctctg acgcctcacg ttccgttcaa gctggtgtcc acctacaaga attactactc   1380

attggtgctg gacagcgctc tggaccgcga gagggtgtcg gcctatgagc tggtggtgac   1440

cgcgcgggac gggggctcgc ctccgctgtg ggccacggcc agcgtgtctg tggaggtggc   1500

cgacgtgaac gacaacgcgc ctgcgttcgc gcagtccgag tacacggtgt tcgtgaagga   1560

gaacaacccg ccaggctgcc acatcttcac ggtgtctgcg tgggacgcgg acgcgcagga   1620

gaacgccctg gtgtcctact ctctggtgga gcggcggttg ggcgagcgct cgctgtcgag   1680

ctacgtgtcg gtgcacgcgg agagcggcaa ggtgtacgcg ctgcagccgc tggaccacga   1740

ggagctggag ctgctacagt tccaggtgag cgcgcgcgat gggggcgtgc cgcctctggg   1800

cagcaacttg acgctgcagg tgttcgtgct ggacgagaac gacaacgctc ccgcgctgct   1860

ggcgtctccc gctggcagcg cgggcggtgc agtcagtgag ctggtgctgc ggtcggtggt   1920

tgcgggtcac gtggtggcta aggtgcgcgc agtggacgct gactctggat acaacgcgtg   1980

gctgtcgtat gaattgcagt cggcggcggt tggtgcacgc atcccgtttc gcgtggggct   2040

gtacacgggc gagatcagta cgacgcgcgc tctggatgag actgactcgc cacgccagcg   2100

cctactggtg ctggtgaagg accatggcga gccgtcgctg acggccacgg ccactgtgct   2160

tgtgtcgctt gtggagggca gccaggcacc caaggcctcg tcgcgggctt cagtgggcgt   2220

ggcgcccgag gtggccctgg tggatgtcaa cgtgtacctg atcatcgcca tctgcgcggt   2280

gtccagcttg ctggtgctca cgctgctgct gtacactgca ctgaggtgct cggcggcgcc   2340

caccgagggc gcatgtgggc cggtgaagcc cacgctggtg tgctctagcg cggtggggag   2400

ctggtcttac tcgcagcaga ggcggcagag ggtgtgttct ggggagggcc tgcccaaggc   2460

ggacctcatg gccttcagcc ccagccttcc accatgccca atggtagatg tggacgggga   2520

agatcagtct attggagggg accactctag gaagccacga cagcccaacc ctgactggcg   2580

ttactctgcc tccctgagag caggcatgca cagctctgtg cacctagagg aggctggcat   2640

tctacgggct ggtccaggag ggcctgatca gcagtggcca acagtatcca gtgcaacacc   2700

agaaccagag gcaggagaag tgtcccctcc agtcggtgcg ggtgtcaaca gcaacagctg   2760

gacctttaaa tacggaccag gcaaccccaa acaatccggt cccggtgagt tgcccgacaa   2820

attcattatc ccaggatctc ctgcaatcat ctccatccgg caggagccta ctaacagcca   2880

aattgacaaa agtgacttca taaccttcgg caaaaaggag gagaccaaga aaaagaagaa   2940

aaagaagaag ggtaacaaga cccaggagaa aaaagagaaa gggaacagca cgactgacaa   3000

cagtgaccag tgaggtcctc aaatggaaac aagccactta gccagttttt gtaataatgg   3060

caaatctctc ccatgtagca attccctgct cctttttcct atctacatga gccctcttag   3120

agacctcaga aatctgcaga aagttccctg tgtctgtcta gaacgcattt aacaggtttt   3180

gtcgtaaaag ctttactaag tctggtgtta actctttctc tccactctgg cttgttttca   3240

gaacctaaaa agcagaccca agtttccttt ctcctccgcc gcaaaggaga ggcttcccag   3300

ccccgccagt gagaggttgg actctctgcc ctgtgctccg gggatcctgt cttgatgaca   3360

cttgcagggc aggctgaaaa gttttgagat tgagcagctt gggagtttgt ggccactggg   3420

tatgtgtggc taccgcgggt atgcgagtgc cagatattgg ctgagacgag ccagcttaga   3480

ctaattggta caaggaaggc aagaaaacaa agacaaataa acagcggaag ttatcagtat   3540

ggaggggaag tgtaaactta aagggaccag actttctaaa tcttacaact caagaggtgg   3600

cagccaccct ctaggagaca aaactacccc cactgacaag gctttaggag accctaaagt   3660

ctgttggctg tgacgtcatt atacctaaaa tctgcatcat acctgcaagc caacagttca   3720

gtgttttaac agagaaccac cctgggaaac agaagcagat ctgatgtgtt tcctatacat   3780

gtcctgtgct cactttatta aaaattcttt tgcacacaat gtttatgaaa aggccagatc   3840

cttttccaat acttatgcaa aagcaaaaga aaaccccgac acctcacctt tcgctgtttg   3900

ttgtttcata gatttattta aaaaaagaga aagtctatag ctataaatct ttaaagagaa   3960

atatgaatac aattccccta aactctcctc aaaagagaat tcagtctaca gccatttaaa   4020

tgatcattgc tgctacagaa gtgctttaag agaattgcct gaaacatctg tattatatcg   4080

gccacctgcc aatcacagct ttactctttc aggtcactct ggggctgcct cttgcatgta   4140

ttactaaata aaatgatctc tctttctctc tctctctctc ttttctaaga aacaattatg   4200

tgcactttga tacacaacct tctctaacca actatatatc aagacccaaa aattgaagaa   4260

aaatattgtt ttctcataca gtgagcagat ttttcaatct actaattctg tgacttgtct   4320

tggtgtgcta gcctacacct tctctttggt ttagttttcc ttttctataa cactctgaat   4380

tgctaatctt actaacacct atgatgttac ctgaaatcaa tctcccatat gtatgctgta   4440

tgctatgcta agactcctga aatatactta ctctgtgctt gtgtatgtga atgttaatgc   4500

aactattacc tagagtgaac tttaagcttt attgttgaat gtaattccat tatatttcct   4560

tttgtacacc tgtgaaaaag tggagtagtg tttttttaac cattgttaat cagcttttgt   4620

gtatgaaaga cacagtaaaa tttctttctt aaatcaagat actggtgatt caaggaattt   4680

tatttatggt ccagccaaga gccatctcgt gccaagactt ctgctggcaa gggaatggat   4740

aaagctgttt tgttctagta acaattttgg aatgaatact gacaatattc catgagggtg   4800

tgcaagcaca aattttacca atctgacctc tttgaagttg cagaatgctt tgaaattcta   4860

atggtatctg aaatatcagc tcatagaaag taacaaaatt tgctgtcacc ttaaataaga   4920

cattttaatt ttgttataat gtacaattta gaagtttgat taattatatt atctatttag   4980

gcattaatat aaaagaggta ggagtctgtt atttaaaaaa agcattaaat ttaaaaaaaa   5040

actgtcttgt ctacttttag cttcattctc ccatattttg aagggtgtgt aacttcagct   5100

ctgcaggatt gcatggggta aaacttgtta ccaacacatg tgaaccattg ctacattgta   5160

ggttgtgatc attttgcccc actgaagccc atgtatctga ccttacgtgc cttttgaact   5220

aggagaatcg ggctaattta ttaatgatga taattataat gtatctgtac agcacttttt   5280

acatttgcga agtgctttcc aatccatgtt agttactagt tattacagct gtaaggataa   5340

aacacgtcat gtggattcat tttgaattgg tgctattggt atttcctctg ttattgctaa   5400

taaatgaaaa tggtggtatg aaa                                           5423


<210>  2193
<211>  948
<212>  PRT
<213>  Homo sapiens

<400>  2193


Met Val Ser Arg Cys Ser Cys Leu Gly Val Gln Cys Leu Leu Leu Ser 
1               5                   10                  15      


Leu Leu Leu Leu Ala Ala Trp Glu Val Gly Ser Gly Gln Leu His Tyr 
            20                  25                  30          


Ser Val Tyr Glu Glu Ala Arg His Gly Thr Phe Val Gly Arg Ile Ala 
        35                  40                  45              


Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Gln Arg Leu Phe Arg 
    50                  55                  60                  


Val Ala Ser Lys Arg His Gly Asp Leu Leu Glu Val Asn Leu Gln Asn 
65                  70                  75                  80  


Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys Gly 
                85                  90                  95      


Arg Ser Val Glu Cys Ser Ile His Leu Glu Val Ile Val Asp Arg Pro 
            100                 105                 110         


Leu Gln Val Phe His Val Asp Val Glu Val Lys Asp Ile Asn Asp Asn 
        115                 120                 125             


Pro Pro Arg Phe Ser Val Thr Glu Gln Lys Leu Ser Ile Pro Glu Ser 
    130                 135                 140                 


Arg Leu Leu Asp Ser Arg Phe Pro Leu Glu Gly Ala Ser Asp Ala Asp 
145                 150                 155                 160 


Val Gly Glu Asn Ala Leu Leu Thr Tyr Lys Leu Ser Pro Asn Glu Tyr 
                165                 170                 175     


Phe Val Leu Asp Ile Ile Asn Lys Lys Asp Lys Asp Lys Phe Pro Val 
            180                 185                 190         


Leu Val Leu Arg Lys Leu Leu Asp Arg Glu Glu Asn Pro Gln Leu Lys 
        195                 200                 205             


Leu Leu Leu Thr Ala Thr Asp Gly Gly Lys Pro Glu Phe Thr Gly Ser 
    210                 215                 220                 


Val Ser Leu Leu Ile Leu Val Leu Asp Ala Asn Asp Asn Ala Pro Ile 
225                 230                 235                 240 


Phe Asp Arg Pro Val Tyr Glu Val Lys Met Tyr Glu Asn Gln Val Asn 
                245                 250                 255     


Gln Thr Leu Val Ile Arg Leu Asn Ala Ser Asp Ser Asp Glu Gly Ile 
            260                 265                 270         


Asn Lys Glu Met Met Tyr Ser Phe Ser Ser Leu Val Pro Pro Thr Ile 
        275                 280                 285             


Arg Arg Lys Phe Trp Ile Asn Glu Arg Thr Gly Glu Ile Lys Val Asn 
    290                 295                 300                 


Asp Ala Ile Asp Phe Glu Asp Ser Asn Thr Tyr Glu Ile His Val Asp 
305                 310                 315                 320 


Val Thr Asp Lys Gly Asn Pro Pro Met Val Gly His Cys Thr Val Leu 
                325                 330                 335     


Val Glu Leu Leu Asp Glu Asn Asp Asn Ser Pro Glu Val Ile Val Thr 
            340                 345                 350         


Ser Leu Ser Leu Pro Val Lys Glu Asp Ala Gln Val Gly Thr Val Ile 
        355                 360                 365             


Ala Leu Ile Ser Val Ser Asp His Asp Ser Gly Ala Asn Gly Gln Val 
    370                 375                 380                 


Thr Cys Ser Leu Thr Pro His Val Pro Phe Lys Leu Val Ser Thr Tyr 
385                 390                 395                 400 


Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu Arg 
                405                 410                 415     


Val Ser Ala Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser Pro 
            420                 425                 430         


Pro Leu Trp Ala Thr Ala Ser Val Ser Val Glu Val Ala Asp Val Asn 
        435                 440                 445             


Asp Asn Ala Pro Ala Phe Ala Gln Ser Glu Tyr Thr Val Phe Val Lys 
    450                 455                 460                 


Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Trp Asp 
465                 470                 475                 480 


Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu Arg 
                485                 490                 495     


Arg Leu Gly Glu Arg Ser Leu Ser Ser Tyr Val Ser Val His Ala Glu 
            500                 505                 510         


Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu Glu 
        515                 520                 525             


Leu Leu Gln Phe Gln Val Ser Ala Arg Asp Gly Gly Val Pro Pro Leu 
    530                 535                 540                 


Gly Ser Asn Leu Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp Asn 
545                 550                 555                 560 


Ala Pro Ala Leu Leu Ala Ser Pro Ala Gly Ser Ala Gly Gly Ala Val 
                565                 570                 575     


Ser Glu Leu Val Leu Arg Ser Val Val Ala Gly His Val Val Ala Lys 
            580                 585                 590         


Val Arg Ala Val Asp Ala Asp Ser Gly Tyr Asn Ala Trp Leu Ser Tyr 
        595                 600                 605             


Glu Leu Gln Ser Ala Ala Val Gly Ala Arg Ile Pro Phe Arg Val Gly 
    610                 615                 620                 


Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Ala Leu Asp Glu Thr Asp 
625                 630                 635                 640 


Ser Pro Arg Gln Arg Leu Leu Val Leu Val Lys Asp His Gly Glu Pro 
                645                 650                 655     


Ser Leu Thr Ala Thr Ala Thr Val Leu Val Ser Leu Val Glu Gly Ser 
            660                 665                 670         


Gln Ala Pro Lys Ala Ser Ser Arg Ala Ser Val Gly Val Ala Pro Glu 
        675                 680                 685             


Val Ala Leu Val Asp Val Asn Val Tyr Leu Ile Ile Ala Ile Cys Ala 
    690                 695                 700                 


Val Ser Ser Leu Leu Val Leu Thr Leu Leu Leu Tyr Thr Ala Leu Arg 
705                 710                 715                 720 


Cys Ser Ala Ala Pro Thr Glu Gly Ala Cys Gly Pro Val Lys Pro Thr 
                725                 730                 735     


Leu Val Cys Ser Ser Ala Val Gly Ser Trp Ser Tyr Ser Gln Gln Arg 
            740                 745                 750         


Arg Gln Arg Val Cys Ser Gly Glu Gly Leu Pro Lys Ala Asp Leu Met 
        755                 760                 765             


Ala Phe Ser Pro Ser Leu Pro Pro Cys Pro Met Val Asp Val Asp Gly 
    770                 775                 780                 


Glu Asp Gln Ser Ile Gly Gly Asp His Ser Arg Lys Pro Arg Gln Pro 
785                 790                 795                 800 


Asn Pro Asp Trp Arg Tyr Ser Ala Ser Leu Arg Ala Gly Met His Ser 
                805                 810                 815     


Ser Val His Leu Glu Glu Ala Gly Ile Leu Arg Ala Gly Pro Gly Gly 
            820                 825                 830         


Pro Asp Gln Gln Trp Pro Thr Val Ser Ser Ala Thr Pro Glu Pro Glu 
        835                 840                 845             


Ala Gly Glu Val Ser Pro Pro Val Gly Ala Gly Val Asn Ser Asn Ser 
    850                 855                 860                 


Trp Thr Phe Lys Tyr Gly Pro Gly Asn Pro Lys Gln Ser Gly Pro Gly 
865                 870                 875                 880 


Glu Leu Pro Asp Lys Phe Ile Ile Pro Gly Ser Pro Ala Ile Ile Ser 
                885                 890                 895     


Ile Arg Gln Glu Pro Thr Asn Ser Gln Ile Asp Lys Ser Asp Phe Ile 
            900                 905                 910         


Thr Phe Gly Lys Lys Glu Glu Thr Lys Lys Lys Lys Lys Lys Lys Lys 
        915                 920                 925             


Gly Asn Lys Thr Gln Glu Lys Lys Glu Lys Gly Asn Ser Thr Thr Asp 
    930                 935                 940                 


Asn Ser Asp Gln 
945             

<210>  2194
<211>  2156
<212>  DNA
<213>  Homo sapiens

<400>  2194
aatggtagat gtggacgggg aagatcagtc tattggaggg gaccactcta ggaagccacg     60

acagcccaac cctgactggc gttactctgc ctccctgaga gcaggcatgc acagctctgt    120

gcacctagag gaggctggca ttctacgggc tggtccagga gggcctgatc agcagtggcc    180

aacagtatcc agtgcaacac cagaaccaga ggcaggagaa gtgtcccctc cagtcggtgc    240

gggtgtcaac agcaacagct ggacctttaa atacggacca ggcaacccca aacaatccgg    300

tcccggtgag ttgcccgaca aattcattat cccaggatct cctgcaatca tctccatccg    360

gcaggagcct actaacagcc aaattgacaa aagtgacttc ataaccttcg gcaaaaagga    420

ggagaccaag aaaaagaaga aaaagaagaa gggtaacaag acccaggaga aaaaagagaa    480

agggaacagc acgactgaca acagtgacca gtgaggtcct caaatggaaa caagccactt    540

agccagtttt tgtaataatg gcaaatctct cccatgtagc aattccctgc tcctttttcc    600

tatctacatg agccctctta gagacctcag aaatctgcag aaagttccct gtgtctgtct    660

agaacgcatt taacaggttt tgtcgtaaaa gctttactaa gtctggtgtt aactctttct    720

ctccactctg gcttgttttc agaacctaaa aagcagaccc aagtttcctt tctcctccgc    780

cgcaaaggag aggcttccca gccccgccag tgagaggttg gactctctgc cctgtgctcc    840

ggggatcctg tcttgatgac acttgcaggg caggctgaaa agttttgaga ttgagcagct    900

tgggagtttg tggccactgg gtatgtgtgg ctaccgcggg tatgcgagtg ccagatattg    960

gctgagacga gccagcttag actaattggt acaaggaagg caagaaaaca aagacaaata   1020

aacagcggaa gttatcagta tggaggggaa gtgtaaactt aaagggacca gactttctaa   1080

atcttacaac tcaagaggtg gcagccaccc tctaggagac aaaactaccc ccactgacaa   1140

ggctttagga gaccctaaag tctgttggct gtgacgtcat tatacctaaa atctgcatca   1200

tacctgcaag ccaacagttc agtgttttaa cagagaacca ccctgggaaa cagaagcaga   1260

tctgatgtgt ttcctataca tgtcctgtgc tcactttatt aaaaattctt ttgcacacaa   1320

tgtttatgaa aaggccagat ccttttccaa tacttatgca aaagcaaaag aaaaccccga   1380

cacctcacct ttcgctgttt gttgtttcat agatttattt aaaaaaagag aaagtctata   1440

gctataaatc tttaaagaga aatatgaata caattcccct aaactctcct caaaagagaa   1500

ttcagtctac agccatttaa atgatcattg ctgctacaga agtgctttaa gagaattgcc   1560

tgaaacatct gtattatatc ggccacctgc caatcacagc tttactcttt caggtcactc   1620

tggggctgcc tcttgcatgt attactaaat aaaatgatct ctctttctct ctctctctct   1680

cttttctaag aaacaattat gtgcactttg atacacaacc ttctctaacc aactatatat   1740

caagacccaa aaattgaaga aaaatattgt tttctcatac agtgagcaga tttttcaatc   1800

tactaattct gtgacttgtc ttggtgtgct agcctacacc ttctctttgg tttagttttc   1860

cttttctata acactctgaa ttgctaatct tactaacacc tatgatgtta cctgaaatca   1920

atctcccata tgtatgctgt atgctatgct aagactcctg aaatatactt actctgtgct   1980

tgtgtatgtg aatgttaatg caactattac ctagagtgaa ctttaagctt tattgttgaa   2040

tgtaattcca ttatatttcc ttttgtacac ctgtgaaaaa gtggagtagt gtttttttaa   2100

ccattgttaa tcagcttttg tgtatgaaag acacagtaaa atttctttct taaatc       2156


<210>  2195
<211>  170
<212>  PRT
<213>  Homo sapiens

<400>  2195


Met Val Asp Val Asp Gly Glu Asp Gln Ser Ile Gly Gly Asp His Ser 
1               5                   10                  15      


Arg Lys Pro Arg Gln Pro Asn Pro Asp Trp Arg Tyr Ser Ala Ser Leu 
            20                  25                  30          


Arg Ala Gly Met His Ser Ser Val His Leu Glu Glu Ala Gly Ile Leu 
        35                  40                  45              


Arg Ala Gly Pro Gly Gly Pro Asp Gln Gln Trp Pro Thr Val Ser Ser 
    50                  55                  60                  


Ala Thr Pro Glu Pro Glu Ala Gly Glu Val Ser Pro Pro Val Gly Ala 
65                  70                  75                  80  


Gly Val Asn Ser Asn Ser Trp Thr Phe Lys Tyr Gly Pro Gly Asn Pro 
                85                  90                  95      


Lys Gln Ser Gly Pro Gly Glu Leu Pro Asp Lys Phe Ile Ile Pro Gly 
            100                 105                 110         


Ser Pro Ala Ile Ile Ser Ile Arg Gln Glu Pro Thr Asn Ser Gln Ile 
        115                 120                 125             


Asp Lys Ser Asp Phe Ile Thr Phe Gly Lys Lys Glu Glu Thr Lys Lys 
    130                 135                 140                 


Lys Lys Lys Lys Lys Lys Gly Asn Lys Thr Gln Glu Lys Lys Glu Lys 
145                 150                 155                 160 


Gly Asn Ser Thr Thr Asp Asn Ser Asp Gln 
                165                 170 

<210>  2196
<211>  5459
<212>  DNA
<213>  Homo sapiens

<400>  2196
cattgattct gttacataaa gtgctaaatt ttgatatctc atattatgct actatggctt     60

acattagaaa taatatatgt caaataaaaa ctcatctaga tcaatagact tttcctttgt    120

ggattctttt ttaaaactac caagtttgag aatatgaata tatttgtttt tcatattgtt    180

ctgcaatgaa tataaagtca cttataatca gaaagcaatt aaatgtaaat aacagtaaag    240

aatgagaact atagaaaata gatatgaaaa tgcaagccca cagagatgag aatagatcat    300

gtggaacata aacactaaag agctgctttt ataaaacttc aattttttct ttgagttccc    360

tagcagccaa agtaacaagg gagactgaaa gtaaaacaat tcaaatttga tagtattttt    420

atatgaggaa caacactttc aggaaatgtt taaccctagt ttttcatgag gccaccttaa    480

caactgaatt ctctttctct ctcactctgt gtataagtat tttagataag taaaagaaca    540

atgttataat gttaagtcaa acatagacac aataatttaa atttgatgtt aatcgagaaa    600

tacaatgcca tttccatata tatttagttt caatatgact tataatctga atattccata    660

aataagcacg ttggaaatat ttgggggaag aaacccaaaa cacgtgaaat tctgtggtgg    720

taaatgcagt gcacagtact cacagtttta ggcgcaaggt gtcgctcttt acttggtgga    780

aagttcattt aaaggttggt ctgaacagtg aggcactccc atacaaagga actccatcat    840

accggatgcc accgtttaag gatcctttga aacttcttaa gaattcaacg agatttttaa    900

cctgaaactg aagaatctgg tactgtaagt gtaaagaagc ttattttgga agccaatttc    960

gtatgcgatg tttggttttc agagaagggg attgggcacc ccacgactac agctctggct   1020

tctcctcctc gaattctggg aggtggggag cggccagctc cactactccg tctcggagga   1080

ggccaaacac ggcaccttcg tgggccgcat cgcgcaggac ctggggctgg agctggcgga   1140

gctggtgcag cgcctgttcc gggtggcgtc caaaacacat ggggaccttc tggaggtaaa   1200

tctgcagaat ggcattttgt ttgtgaattc tcggatcgac cgcgaggagc tgtgcgggca   1260

gagcgcggag tgcagcatcc acctggaggt gatcgtggac aggccgctgc aggttttcca   1320

tgtgaacgtg gaggtgaagg acattaacga caacccgccg gtgttctcgc tcagagaaca   1380

aaagctgctg attgcggaat ctaagcaatc ggactcgcgt tttccactag agggagcttc   1440

tgatgctgac attgaagaga atgctctatt gacctacagg ctaagtaaaa atgagtattt   1500

ttctttagat tcaccaacaa atggtaagca gattaaaaga ctgtcactta ttttaaagaa   1560

gtctctggat agagagaaaa ctccggaact taatttgctg ctaacagcta cagacggggg   1620

aaaaccagag cttactggca ccgttcggct gttagtccaa gtcttggatg tcaacgacaa   1680

tgatccagag tttgataaat cagaatataa ggtgagcctt atggaaaatg ctgctaaaga   1740

aactcttgtg ctcaaactaa acgccacaga ccgagacgaa ggagtcaatg gagaggtaac   1800

atactcctta atgtcaatta agcccaatgg aagacactta tttacactag atcaaaataa   1860

tggagaagtg agggtcaatg gaactttaga ttatgaagaa aacaagtttt ataaaattga   1920

agtacaggct acagataagg ggactccccc aatggcaggt cactgtacag tctgggtgga   1980

aatcttggac accaacgata actctcctga agtcgccgtg acttccttgt ccctcccagt   2040

acgagaggac gctcagccca gcacggtcat tgccctgatc agcgtgtctg accgtgactc   2100

aggtgtcaac ggacaggtga cctgctcgct gacgccccac gttcccttca agctggtgtc   2160

caccttcaag aattactact cgttggtgct ggacagcgcc ctggaccgcg agaacgtgtg   2220

ggcctatgaa ctggtggtga ctgcgcggga tgggggttcg ccttctctgt gggccacggc   2280

cagggtatcc gtggaggtgg ccgacgtgaa cgacaatgcg cctgcgttcg cacagcccga   2340

gtacaccgtg ttcgtgaagg agaacaaccc accaggctgc cacatcttca cagtgtcggc   2400

gcgggacgcg gacgcgcagg agaacgcgct ggtgtcctac tcgctggtgg agcggcggtt   2460

gggcgaccgc gcgctgtcga gctacgtgtc ggtgcacgcg gagagcggca aggtgtacgc   2520

gctgcagccg ttggaccacg aggagctgga gctgctacag ttccaggtga gcgcgcgcga   2580

tgcgggcgtg ccgcctctga gcagcaacgt gacgctgcag gtgttcgtgc tggacgagaa   2640

cgacaacgcg ccggcactgc tggcgactca ggctggcagc gcgggaggcg cagttaacaa   2700

gctagtaccg cggtcggtgg gtgcgggcca cgtggtggcg aaggtgcgcg cagtggatgc   2760

ggactcaggc tacaacgcgt ggctttcata tgaattgcag ccggcggcgg gcggctcgcg   2820

catcccgttc cgcgtggggc tgtacacggg cgagataagc acaacgcgtg ccctggacga   2880

ggcagactcg ccgcgccacc gacttctagt actggtgaag gatcacggtg agccggcgct   2940

gacggccacg gccaccgtgc tggtgtcgtt ggtggagagc ggacaggcgc caaaggcctc   3000

ttcccggact ttggcgggcg ccgcgagccc agaggctgcg ctggtggatg tcaacgtgta   3060

cctgatcatc gccatctgcg tggtgtccag cctcctggta ctcacgctgc tgctgtatac   3120

ggcgctgtgg tggtcggcaa cgcccactga gggcgcgtgc gcgccgggga agcccacgct   3180

ggtgtgctcc cgcgcggtgg ggagctggtc atactcgcag cagaggcggc agagggtgtg   3240

ctctgaggag ggcccaccta agacggacct catggccttc agccccagtc ttcctctagg   3300

tctgaataaa gaggaggaag gggaaagaca ggagccaggg tcaaatcacc ccggacagcc   3360

acgacagccc aaccctgact ggcgttactc tgcctccctg agagcaggca tgcacagctc   3420

tgtgcaccta gaggaggctg gcattctacg ggctggtcca ggagggcctg atcagcagtg   3480

gccaacagta tccagtgcaa caccagaacc agaggcagga gaagtgtccc ctccagtcgg   3540

tgcgggtgtc aacagcaaca gctggacctt taaatacgga ccaggcaacc ccaaacaatc   3600

cggtcccggt gagttgcccg acaaattcat tatcccagga tctcctgcaa tcatctccat   3660

ccggcaggag cctactaaca gccaaattga caaaagtgac ttcataacct tcggcaaaaa   3720

ggaggagacc aagaaaaaga agaaaaagaa gaagggtaac aagacccagg agaaaaaaga   3780

gaaagggaac agcacgactg acaacagtga ccagtgaggt cctcaaatgg aaacaagcca   3840

cttagccagt ttttgtaata atggcaaatc tctcccatgt agcaattccc tgctcctttt   3900

tcctatctac atgagccctc ttagagacct cagaaatctg cagaaagttc cctgtgtctg   3960

tctagaacgc atttaacagg ttttgtcgta aaagctttac taagtctggt gttaactctt   4020

tctctccact ctggcttgtt ttcagaacct aaaaagcaga cccaagtttc ctttctcctc   4080

cgccgcaaag gagaggcttc ccagccccgc cagtgagagg ttggactctc tgccctgtgc   4140

tccggggatc ctgtcttgat gacacttgca gggcaggctg aaaagttttg agattgagca   4200

gcttgggagt ttgtggccac tgggtatgtg tggctaccgc gggtatgcga gtgccagata   4260

ttggctgaga cgagccagct tagactaatt ggtacaagga aggcaagaaa acaaagacaa   4320

ataaacagcg gaagttatca gtatggaggg gaagtgtaaa cttaaaggga ccagactttc   4380

taaatcttac aactcaagag gtggcagcca ccctctagga gacaaaacta cccccactga   4440

caaggcttta ggagacccta aagtctgttg gctgtgacgt cattatacct aaaatctgca   4500

tcatacctgc aagccaacag ttcagtgttt taacagagaa ccaccctggg aaacagaagc   4560

agatctgatg tgtttcctat acatgtcctg tgctcacttt attaaaaatt cttttgcaca   4620

caatgtttat gaaaaggcca gatccttttc caatacttat gcaaaagcaa aagaaaaccc   4680

cgacacctca cctttcgctg tttgttgttt catagattta tttaaaaaaa gagaaagtct   4740

atagctataa atctttaaag agaaatatga atacaattcc cctaaactct cctcaaaaga   4800

gaattcagtc tacagccatt taaatgatca ttgctgctac agaagtgctt taagagaatt   4860

gcctgaaaca tctgtattat atcggccacc tgccaatcac agctttactc tttcaggtca   4920

ctctggggct gcctcttgca tgtattacta aataaaatga tctctctttc tctctctctc   4980

tctcttttct aagaaacaat tatgtgcact ttgatacaca accttctcta accaactata   5040

tatcaagacc caaaaattga agaaaaatat tgttttctca tacagtgagc agatttttca   5100

atctactaat tctgtgactt gtcttggtgt gctagcctac accttctctt tggtttagtt   5160

ttccttttct ataacactct gaattgctaa tcttactaac acctatgatg ttacctgaaa   5220

tcaatctccc atatgtatgc tgtatgctat gctaagactc ctgaaatata cttactctgt   5280

gcttgtgtat gtgaatgtta atgcaactat tacctagagt gaactttaag ctttattgtt   5340

gaatgtaatt ccattatatt tccttttgta cacctgtgaa aaagtggagt agtgtttttt   5400

taaccattgt taatcagctt ttgtgtatga aagacacagt aaaatttctt tcttaaatc    5459


<210>  2197
<211>  949
<212>  PRT
<213>  Homo sapiens

<400>  2197


Met Phe Gly Phe Gln Arg Arg Gly Leu Gly Thr Pro Arg Leu Gln Leu 
1               5                   10                  15      


Trp Leu Leu Leu Leu Glu Phe Trp Glu Val Gly Ser Gly Gln Leu His 
            20                  25                  30          


Tyr Ser Val Ser Glu Glu Ala Lys His Gly Thr Phe Val Gly Arg Ile 
        35                  40                  45              


Ala Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Gln Arg Leu Phe 
    50                  55                  60                  


Arg Val Ala Ser Lys Thr His Gly Asp Leu Leu Glu Val Asn Leu Gln 
65                  70                  75                  80  


Asn Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Gly Gln Ser Ala Glu Cys Ser Ile His Leu Glu Val Ile Val Asp Arg 
            100                 105                 110         


Pro Leu Gln Val Phe His Val Asn Val Glu Val Lys Asp Ile Asn Asp 
        115                 120                 125             


Asn Pro Pro Val Phe Ser Leu Arg Glu Gln Lys Leu Leu Ile Ala Glu 
    130                 135                 140                 


Ser Lys Gln Ser Asp Ser Arg Phe Pro Leu Glu Gly Ala Ser Asp Ala 
145                 150                 155                 160 


Asp Ile Glu Glu Asn Ala Leu Leu Thr Tyr Arg Leu Ser Lys Asn Glu 
                165                 170                 175     


Tyr Phe Ser Leu Asp Ser Pro Thr Asn Gly Lys Gln Ile Lys Arg Leu 
            180                 185                 190         


Ser Leu Ile Leu Lys Lys Ser Leu Asp Arg Glu Lys Thr Pro Glu Leu 
        195                 200                 205             


Asn Leu Leu Leu Thr Ala Thr Asp Gly Gly Lys Pro Glu Leu Thr Gly 
    210                 215                 220                 


Thr Val Arg Leu Leu Val Gln Val Leu Asp Val Asn Asp Asn Asp Pro 
225                 230                 235                 240 


Glu Phe Asp Lys Ser Glu Tyr Lys Val Ser Leu Met Glu Asn Ala Ala 
                245                 250                 255     


Lys Glu Thr Leu Val Leu Lys Leu Asn Ala Thr Asp Arg Asp Glu Gly 
            260                 265                 270         


Val Asn Gly Glu Val Thr Tyr Ser Leu Met Ser Ile Lys Pro Asn Gly 
        275                 280                 285             


Arg His Leu Phe Thr Leu Asp Gln Asn Asn Gly Glu Val Arg Val Asn 
    290                 295                 300                 


Gly Thr Leu Asp Tyr Glu Glu Asn Lys Phe Tyr Lys Ile Glu Val Gln 
305                 310                 315                 320 


Ala Thr Asp Lys Gly Thr Pro Pro Met Ala Gly His Cys Thr Val Trp 
                325                 330                 335     


Val Glu Ile Leu Asp Thr Asn Asp Asn Ser Pro Glu Val Ala Val Thr 
            340                 345                 350         


Ser Leu Ser Leu Pro Val Arg Glu Asp Ala Gln Pro Ser Thr Val Ile 
        355                 360                 365             


Ala Leu Ile Ser Val Ser Asp Arg Asp Ser Gly Val Asn Gly Gln Val 
    370                 375                 380                 


Thr Cys Ser Leu Thr Pro His Val Pro Phe Lys Leu Val Ser Thr Phe 
385                 390                 395                 400 


Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu Asn 
                405                 410                 415     


Val Trp Ala Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser Pro 
            420                 425                 430         


Ser Leu Trp Ala Thr Ala Arg Val Ser Val Glu Val Ala Asp Val Asn 
        435                 440                 445             


Asp Asn Ala Pro Ala Phe Ala Gln Pro Glu Tyr Thr Val Phe Val Lys 
    450                 455                 460                 


Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Arg Asp 
465                 470                 475                 480 


Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu Arg 
                485                 490                 495     


Arg Leu Gly Asp Arg Ala Leu Ser Ser Tyr Val Ser Val His Ala Glu 
            500                 505                 510         


Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu Glu 
        515                 520                 525             


Leu Leu Gln Phe Gln Val Ser Ala Arg Asp Ala Gly Val Pro Pro Leu 
    530                 535                 540                 


Ser Ser Asn Val Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp Asn 
545                 550                 555                 560 


Ala Pro Ala Leu Leu Ala Thr Gln Ala Gly Ser Ala Gly Gly Ala Val 
                565                 570                 575     


Asn Lys Leu Val Pro Arg Ser Val Gly Ala Gly His Val Val Ala Lys 
            580                 585                 590         


Val Arg Ala Val Asp Ala Asp Ser Gly Tyr Asn Ala Trp Leu Ser Tyr 
        595                 600                 605             


Glu Leu Gln Pro Ala Ala Gly Gly Ser Arg Ile Pro Phe Arg Val Gly 
    610                 615                 620                 


Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Ala Leu Asp Glu Ala Asp 
625                 630                 635                 640 


Ser Pro Arg His Arg Leu Leu Val Leu Val Lys Asp His Gly Glu Pro 
                645                 650                 655     


Ala Leu Thr Ala Thr Ala Thr Val Leu Val Ser Leu Val Glu Ser Gly 
            660                 665                 670         


Gln Ala Pro Lys Ala Ser Ser Arg Thr Leu Ala Gly Ala Ala Ser Pro 
        675                 680                 685             


Glu Ala Ala Leu Val Asp Val Asn Val Tyr Leu Ile Ile Ala Ile Cys 
    690                 695                 700                 


Val Val Ser Ser Leu Leu Val Leu Thr Leu Leu Leu Tyr Thr Ala Leu 
705                 710                 715                 720 


Trp Trp Ser Ala Thr Pro Thr Glu Gly Ala Cys Ala Pro Gly Lys Pro 
                725                 730                 735     


Thr Leu Val Cys Ser Arg Ala Val Gly Ser Trp Ser Tyr Ser Gln Gln 
            740                 745                 750         


Arg Arg Gln Arg Val Cys Ser Glu Glu Gly Pro Pro Lys Thr Asp Leu 
        755                 760                 765             


Met Ala Phe Ser Pro Ser Leu Pro Leu Gly Leu Asn Lys Glu Glu Glu 
    770                 775                 780                 


Gly Glu Arg Gln Glu Pro Gly Ser Asn His Pro Gly Gln Pro Arg Gln 
785                 790                 795                 800 


Pro Asn Pro Asp Trp Arg Tyr Ser Ala Ser Leu Arg Ala Gly Met His 
                805                 810                 815     


Ser Ser Val His Leu Glu Glu Ala Gly Ile Leu Arg Ala Gly Pro Gly 
            820                 825                 830         


Gly Pro Asp Gln Gln Trp Pro Thr Val Ser Ser Ala Thr Pro Glu Pro 
        835                 840                 845             


Glu Ala Gly Glu Val Ser Pro Pro Val Gly Ala Gly Val Asn Ser Asn 
    850                 855                 860                 


Ser Trp Thr Phe Lys Tyr Gly Pro Gly Asn Pro Lys Gln Ser Gly Pro 
865                 870                 875                 880 


Gly Glu Leu Pro Asp Lys Phe Ile Ile Pro Gly Ser Pro Ala Ile Ile 
                885                 890                 895     


Ser Ile Arg Gln Glu Pro Thr Asn Ser Gln Ile Asp Lys Ser Asp Phe 
            900                 905                 910         


Ile Thr Phe Gly Lys Lys Glu Glu Thr Lys Lys Lys Lys Lys Lys Lys 
        915                 920                 925             


Lys Gly Asn Lys Thr Gln Glu Lys Lys Glu Lys Gly Asn Ser Thr Thr 
    930                 935                 940                 


Asp Asn Ser Asp Gln 
945                 

<210>  2198
<211>  6227
<212>  DNA
<213>  Homo sapiens

<400>  2198
cattgattct gttacataaa gtgctaaatt ttgatatctc atattatgct actatggctt     60

acattagaaa taatatatgt caaataaaaa ctcatctaga tcaatagact tttcctttgt    120

ggattctttt ttaaaactac caagtttgag aatatgaata tatttgtttt tcatattgtt    180

ctgcaatgaa tataaagtca cttataatca gaaagcaatt aaatgtaaat aacagtaaag    240

aatgagaact atagaaaata gatatgaaaa tgcaagccca cagagatgag aatagatcat    300

gtggaacata aacactaaag agctgctttt ataaaacttc aattttttct ttgagttccc    360

tagcagccaa agtaacaagg gagactgaaa gtaaaacaat tcaaatttga tagtattttt    420

atatgaggaa caacactttc aggaaatgtt taaccctagt ttttcatgag gccaccttaa    480

caactgaatt ctctttctct ctcactctgt gtataagtat tttagataag taaaagaaca    540

atgttataat gttaagtcaa acatagacac aataatttaa atttgatgtt aatcgagaaa    600

tacaatgcca tttccatata tatttagttt caatatgact tataatctga atattccata    660

aataagcacg ttggaaatat ttgggggaag aaacccaaaa cacgtgaaat tctgtggtgg    720

taaatgcagt gcacagtact cacagtttta ggcgcaaggt gtcgctcttt acttggtgga    780

aagttcattt aaaggttggt ctgaacagtg aggcactccc atacaaagga actccatcat    840

accggatgcc accgtttaag gatcctttga aacttcttaa gaattcaacg agatttttaa    900

cctgaaactg aagaatctgg tactgtaagt gtaaagaagc ttattttgga agccaatttc    960

gtatgcgatg tttggttttc agagaagggg attgggcacc ccacgactac agctctggct   1020

tctcctcctc gaattctggg aggtggggag cggccagctc cactactccg tctcggagga   1080

ggccaaacac ggcaccttcg tgggccgcat cgcgcaggac ctggggctgg agctggcgga   1140

gctggtgcag cgcctgttcc gggtggcgtc caaaacacat ggggaccttc tggaggtaaa   1200

tctgcagaat ggcattttgt ttgtgaattc tcggatcgac cgcgaggagc tgtgcgggca   1260

gagcgcggag tgcagcatcc acctggaggt gatcgtggac aggccgctgc aggttttcca   1320

tgtgaacgtg gaggtgaagg acattaacga caacccgccg gtgttctcgc tcagagaaca   1380

aaagctgctg attgcggaat ctaagcaatc ggactcgcgt tttccactag agggagcttc   1440

tgatgctgac attgaagaga atgctctatt gacctacagg ctaagtaaaa atgagtattt   1500

ttctttagat tcaccaacaa atggtaagca gattaaaaga ctgtcactta ttttaaagaa   1560

gtctctggat agagagaaaa ctccggaact taatttgctg ctaacagcta cagacggggg   1620

aaaaccagag cttactggca ccgttcggct gttagtccaa gtcttggatg tcaacgacaa   1680

tgatccagag tttgataaat cagaatataa ggtgagcctt atggaaaatg ctgctaaaga   1740

aactcttgtg ctcaaactaa acgccacaga ccgagacgaa ggagtcaatg gagaggtaac   1800

atactcctta atgtcaatta agcccaatgg aagacactta tttacactag atcaaaataa   1860

tggagaagtg agggtcaatg gaactttaga ttatgaagaa aacaagtttt ataaaattga   1920

agtacaggct acagataagg ggactccccc aatggcaggt cactgtacag tctgggtgga   1980

aatcttggac accaacgata actctcctga agtcgccgtg acttccttgt ccctcccagt   2040

acgagaggac gctcagccca gcacggtcat tgccctgatc agcgtgtctg accgtgactc   2100

aggtgtcaac ggacaggtga cctgctcgct gacgccccac gttcccttca agctggtgtc   2160

caccttcaag aattactact cgttggtgct ggacagcgcc ctggaccgcg agaacgtgtg   2220

ggcctatgaa ctggtggtga ctgcgcggga tgggggttcg ccttctctgt gggccacggc   2280

cagggtatcc gtggaggtgg ccgacgtgaa cgacaatgcg cctgcgttcg cacagcccga   2340

gtacaccgtg ttcgtgaagg agaacaaccc accaggctgc cacatcttca cagtgtcggc   2400

gcgggacgcg gacgcgcagg agaacgcgct ggtgtcctac tcgctggtgg agcggcggtt   2460

gggcgaccgc gcgctgtcga gctacgtgtc ggtgcacgcg gagagcggca aggtgtacgc   2520

gctgcagccg ttggaccacg aggagctgga gctgctacag ttccaggtga gcgcgcgcga   2580

tgcgggcgtg ccgcctctga gcagcaacgt gacgctgcag gtgttcgtgc tggacgagaa   2640

cgacaacgcg ccggcactgc tggcgactca ggctggcagc gcgggaggcg cagttaacaa   2700

gctagtaccg cggtcggtgg gtgcgggcca cgtggtggcg aaggtgcgcg cagtggatgc   2760

ggactcaggc tacaacgcgt ggctttcata tgaattgcag ccggcggcgg gcggctcgcg   2820

catcccgttc cgcgtggggc tgtacacggg cgagataagc acaacgcgtg ccctggacga   2880

ggcagactcg ccgcgccacc gacttctagt actggtgaag gatcacggtg agccggcgct   2940

gacggccacg gccaccgtgc tggtgtcgtt ggtggagagc ggacaggcgc caaaggcctc   3000

ttcccggact ttggcgggcg ccgcgagccc agaggctgcg ctggtggatg tcaacgtgta   3060

cctgatcatc gccatctgcg tggtgtccag cctcctggta ctcacgctgc tgctgtatac   3120

ggcgctgtgg tggtcggcaa cgcccactga gggcgcgtgc gcgccgggga agcccacgct   3180

ggtgtgctcc cgcgcggtgg ggagctggtc atactcgcag cagaggcggc agagggtgtg   3240

ctctgaggag ggcccaccta agacggacct catggccttc agccccagtc ttcctctagg   3300

tctgaataaa gaggaggaag gggaaagaca ggagccaggg tcaaatcacc ccggacagcc   3360

acgacagccc aaccctgact ggcgttactc tgcctccctg agagcaggca tgcacagctc   3420

tgtgcaccta gaggaggctg gcattctacg ggctggtcca ggagggcctg atcagcagtg   3480

gccaacagta tccagtgcaa caccagaacc agaggcagga gaagtgtccc ctccagtcgg   3540

tgcgggtgtc aacagcaaca gctggacctt taaatacgga ccaggcaacc ccaaacaatc   3600

cggtcccggt gagttgcccg acaaattcat tatcccagga tctcctgcaa tcatctccat   3660

ccggcaggag cctactaaca gccaaattga caaaagtgac ttcataacct tcggcaaaaa   3720

ggaggagacc aagaaaaaga agaaaaagaa gaagggtaac aagacccagg agaaaaaaga   3780

gaaagggaac agcacgactg acaacagtga ccagtgaggt cctcaaatgg aaacaagcca   3840

cttagccagt ttttgtaata atggcaaatc tctcccatgt agcaattccc tgctcctttt   3900

tcctatctac atgagccctc ttagagacct cagaaatctg cagaaagttc cctgtgtctg   3960

tctagaacgc atttaacagg ttttgtcgta aaagctttac taagtctggt gttaactctt   4020

tctctccact ctggcttgtt ttcagaacct aaaaagcaga cccaagtttc ctttctcctc   4080

cgccgcaaag gagaggcttc ccagccccgc cagtgagagg ttggactctc tgccctgtgc   4140

tccggggatc ctgtcttgat gacacttgca gggcaggctg aaaagttttg agattgagca   4200

gcttgggagt ttgtggccac tgggtatgtg tggctaccgc gggtatgcga gtgccagata   4260

ttggctgaga cgagccagct tagactaatt ggtacaagga aggcaagaaa acaaagacaa   4320

ataaacagcg gaagttatca gtatggaggg gaagtgtaaa cttaaaggga ccagactttc   4380

taaatcttac aactcaagag gtggcagcca ccctctagga gacaaaacta cccccactga   4440

caaggcttta ggagacccta aagtctgttg gctgtgacgt cattatacct aaaatctgca   4500

tcatacctgc aagccaacag ttcagtgttt taacagagaa ccaccctggg aaacagaagc   4560

agatctgatg tgtttcctat acatgtcctg tgctcacttt attaaaaatt cttttgcaca   4620

caatgtttat gaaaaggcca gatccttttc caatacttat gcaaaagcaa aagaaaaccc   4680

cgacacctca cctttcgctg tttgttgttt catagattta tttaaaaaaa gagaaagtct   4740

atagctataa atctttaaag agaaatatga atacaattcc cctaaactct cctcaaaaga   4800

gaattcagtc tacagccatt taaatgatca ttgctgctac agaagtgctt taagagaatt   4860

gcctgaaaca tctgtattat atcggccacc tgccaatcac agctttactc tttcaggtca   4920

ctctggggct gcctcttgca tgtattacta aataaaatga tctctctttc tctctctctc   4980

tctcttttct aagaaacaat tatgtgcact ttgatacaca accttctcta accaactata   5040

tatcaagacc caaaaattga agaaaaatat tgttttctca tacagtgagc agatttttca   5100

atctactaat tctgtgactt gtcttggtgt gctagcctac accttctctt tggtttagtt   5160

ttccttttct ataacactct gaattgctaa tcttactaac acctatgatg ttacctgaaa   5220

tcaatctccc atatgtatgc tgtatgctat gctaagactc ctgaaatata cttactctgt   5280

gcttgtgtat gtgaatgtta atgcaactat tacctagagt gaactttaag ctttattgtt   5340

gaatgtaatt ccattatatt tccttttgta cacctgtgaa aaagtggagt agtgtttttt   5400

taaccattgt taatcagctt ttgtgtatga aagacacagt aaaatttctt tcttaaatca   5460

agatactggt gattcaagga attttattta tggtccagcc aagagccatc tcgtgccaag   5520

acttctgctg gcaagggaat ggataaagct gttttgttct agtaacaatt ttggaatgaa   5580

tactgacaat attccatgag ggtgtgcaag cacaaatttt accaatctga cctctttgaa   5640

gttgcagaat gctttgaaat tctaatggta tctgaaatat cagctcatag aaagtaacaa   5700

aatttgctgt caccttaaat aagacatttt aattttgtta taatgtacaa tttagaagtt   5760

tgattaatta tattatctat ttaggcatta atataaaaga ggtaggagtc tgttatttaa   5820

aaaaagcatt aaatttaaaa aaaaactgtc ttgtctactt ttagcttcat tctcccatat   5880

tttgaagggt gtgtaacttc agctctgcag gattgcatgg ggtaaaactt gttaccaaca   5940

catgtgaacc attgctacat tgtaggttgt gatcattttg ccccactgaa gcccatgtat   6000

ctgaccttac gtgccttttg aactaggaga atcgggctaa tttattaatg atgataatta   6060

taatgtatct gtacagcact ttttacattt gcgaagtgct ttccaatcca tgttagttac   6120

tagttattac agctgtaagg ataaaacacg tcatgtggat tcattttgaa ttggtgctat   6180

tggtatttcc tctgttattg ctaataaatg aaaatggtgg tatgaaa                 6227


<210>  2199
<211>  949
<212>  PRT
<213>  Homo sapiens

<400>  2199


Met Phe Gly Phe Gln Arg Arg Gly Leu Gly Thr Pro Arg Leu Gln Leu 
1               5                   10                  15      


Trp Leu Leu Leu Leu Glu Phe Trp Glu Val Gly Ser Gly Gln Leu His 
            20                  25                  30          


Tyr Ser Val Ser Glu Glu Ala Lys His Gly Thr Phe Val Gly Arg Ile 
        35                  40                  45              


Ala Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Gln Arg Leu Phe 
    50                  55                  60                  


Arg Val Ala Ser Lys Thr His Gly Asp Leu Leu Glu Val Asn Leu Gln 
65                  70                  75                  80  


Asn Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Gly Gln Ser Ala Glu Cys Ser Ile His Leu Glu Val Ile Val Asp Arg 
            100                 105                 110         


Pro Leu Gln Val Phe His Val Asn Val Glu Val Lys Asp Ile Asn Asp 
        115                 120                 125             


Asn Pro Pro Val Phe Ser Leu Arg Glu Gln Lys Leu Leu Ile Ala Glu 
    130                 135                 140                 


Ser Lys Gln Ser Asp Ser Arg Phe Pro Leu Glu Gly Ala Ser Asp Ala 
145                 150                 155                 160 


Asp Ile Glu Glu Asn Ala Leu Leu Thr Tyr Arg Leu Ser Lys Asn Glu 
                165                 170                 175     


Tyr Phe Ser Leu Asp Ser Pro Thr Asn Gly Lys Gln Ile Lys Arg Leu 
            180                 185                 190         


Ser Leu Ile Leu Lys Lys Ser Leu Asp Arg Glu Lys Thr Pro Glu Leu 
        195                 200                 205             


Asn Leu Leu Leu Thr Ala Thr Asp Gly Gly Lys Pro Glu Leu Thr Gly 
    210                 215                 220                 


Thr Val Arg Leu Leu Val Gln Val Leu Asp Val Asn Asp Asn Asp Pro 
225                 230                 235                 240 


Glu Phe Asp Lys Ser Glu Tyr Lys Val Ser Leu Met Glu Asn Ala Ala 
                245                 250                 255     


Lys Glu Thr Leu Val Leu Lys Leu Asn Ala Thr Asp Arg Asp Glu Gly 
            260                 265                 270         


Val Asn Gly Glu Val Thr Tyr Ser Leu Met Ser Ile Lys Pro Asn Gly 
        275                 280                 285             


Arg His Leu Phe Thr Leu Asp Gln Asn Asn Gly Glu Val Arg Val Asn 
    290                 295                 300                 


Gly Thr Leu Asp Tyr Glu Glu Asn Lys Phe Tyr Lys Ile Glu Val Gln 
305                 310                 315                 320 


Ala Thr Asp Lys Gly Thr Pro Pro Met Ala Gly His Cys Thr Val Trp 
                325                 330                 335     


Val Glu Ile Leu Asp Thr Asn Asp Asn Ser Pro Glu Val Ala Val Thr 
            340                 345                 350         


Ser Leu Ser Leu Pro Val Arg Glu Asp Ala Gln Pro Ser Thr Val Ile 
        355                 360                 365             


Ala Leu Ile Ser Val Ser Asp Arg Asp Ser Gly Val Asn Gly Gln Val 
    370                 375                 380                 


Thr Cys Ser Leu Thr Pro His Val Pro Phe Lys Leu Val Ser Thr Phe 
385                 390                 395                 400 


Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu Asn 
                405                 410                 415     


Val Trp Ala Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser Pro 
            420                 425                 430         


Ser Leu Trp Ala Thr Ala Arg Val Ser Val Glu Val Ala Asp Val Asn 
        435                 440                 445             


Asp Asn Ala Pro Ala Phe Ala Gln Pro Glu Tyr Thr Val Phe Val Lys 
    450                 455                 460                 


Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Arg Asp 
465                 470                 475                 480 


Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu Arg 
                485                 490                 495     


Arg Leu Gly Asp Arg Ala Leu Ser Ser Tyr Val Ser Val His Ala Glu 
            500                 505                 510         


Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu Glu 
        515                 520                 525             


Leu Leu Gln Phe Gln Val Ser Ala Arg Asp Ala Gly Val Pro Pro Leu 
    530                 535                 540                 


Ser Ser Asn Val Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp Asn 
545                 550                 555                 560 


Ala Pro Ala Leu Leu Ala Thr Gln Ala Gly Ser Ala Gly Gly Ala Val 
                565                 570                 575     


Asn Lys Leu Val Pro Arg Ser Val Gly Ala Gly His Val Val Ala Lys 
            580                 585                 590         


Val Arg Ala Val Asp Ala Asp Ser Gly Tyr Asn Ala Trp Leu Ser Tyr 
        595                 600                 605             


Glu Leu Gln Pro Ala Ala Gly Gly Ser Arg Ile Pro Phe Arg Val Gly 
    610                 615                 620                 


Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Ala Leu Asp Glu Ala Asp 
625                 630                 635                 640 


Ser Pro Arg His Arg Leu Leu Val Leu Val Lys Asp His Gly Glu Pro 
                645                 650                 655     


Ala Leu Thr Ala Thr Ala Thr Val Leu Val Ser Leu Val Glu Ser Gly 
            660                 665                 670         


Gln Ala Pro Lys Ala Ser Ser Arg Thr Leu Ala Gly Ala Ala Ser Pro 
        675                 680                 685             


Glu Ala Ala Leu Val Asp Val Asn Val Tyr Leu Ile Ile Ala Ile Cys 
    690                 695                 700                 


Val Val Ser Ser Leu Leu Val Leu Thr Leu Leu Leu Tyr Thr Ala Leu 
705                 710                 715                 720 


Trp Trp Ser Ala Thr Pro Thr Glu Gly Ala Cys Ala Pro Gly Lys Pro 
                725                 730                 735     


Thr Leu Val Cys Ser Arg Ala Val Gly Ser Trp Ser Tyr Ser Gln Gln 
            740                 745                 750         


Arg Arg Gln Arg Val Cys Ser Glu Glu Gly Pro Pro Lys Thr Asp Leu 
        755                 760                 765             


Met Ala Phe Ser Pro Ser Leu Pro Leu Gly Leu Asn Lys Glu Glu Glu 
    770                 775                 780                 


Gly Glu Arg Gln Glu Pro Gly Ser Asn His Pro Gly Gln Pro Arg Gln 
785                 790                 795                 800 


Pro Asn Pro Asp Trp Arg Tyr Ser Ala Ser Leu Arg Ala Gly Met His 
                805                 810                 815     


Ser Ser Val His Leu Glu Glu Ala Gly Ile Leu Arg Ala Gly Pro Gly 
            820                 825                 830         


Gly Pro Asp Gln Gln Trp Pro Thr Val Ser Ser Ala Thr Pro Glu Pro 
        835                 840                 845             


Glu Ala Gly Glu Val Ser Pro Pro Val Gly Ala Gly Val Asn Ser Asn 
    850                 855                 860                 


Ser Trp Thr Phe Lys Tyr Gly Pro Gly Asn Pro Lys Gln Ser Gly Pro 
865                 870                 875                 880 


Gly Glu Leu Pro Asp Lys Phe Ile Ile Pro Gly Ser Pro Ala Ile Ile 
                885                 890                 895     


Ser Ile Arg Gln Glu Pro Thr Asn Ser Gln Ile Asp Lys Ser Asp Phe 
            900                 905                 910         


Ile Thr Phe Gly Lys Lys Glu Glu Thr Lys Lys Lys Lys Lys Lys Lys 
        915                 920                 925             


Lys Gly Asn Lys Thr Gln Glu Lys Lys Glu Lys Gly Asn Ser Thr Thr 
    930                 935                 940                 


Asp Asn Ser Asp Gln 
945                 

<210>  2200
<211>  1941
<212>  DNA
<213>  Homo sapiens

<400>  2200
ggtgtccagc ctcctggtac tcacgctgct gctgtatacg gcgctgtggt ggtcggcaac     60

gcccactgag ggcgcgtgcg cgccggggaa gcccacgctg gtgtgctccc gcgcggtggg    120

gagctggtca tactcgcagc agaggcggca gagggtgtgc tctgaggagg gcccacctaa    180

gacggacctc atggccttca gccccagtct tcctctaggt ctgaataaag aggaggaagg    240

ggaaagacag gagccagggt caaatcaccc cggacagcca cgacagccca accctgactg    300

gcgttactct gcctccctga gagcaggcat gcacagctct gtgcacctag aggaggctgg    360

cattctacgg gctggtccag gagggcctga tcagcagtgg ccaacagtat ccagtgcaac    420

accagaacca gaggcaggag aagtgtcccc tccagtcggt gcgggtgtca acagcaacag    480

ctggaccttt aaatacggac caggcaaccc caaacaatcc ggtcccgaac ctaaaaagca    540

gacccaagtt tcctttctcc tccgccgcaa aggagaggct tcccagcccc gccagtgaga    600

ggttggactc tctgccctgt gctccgggga tcctgtcttg atgacacttg cagggcaggc    660

tgaaaagttt tgagattgag cagcttggga gtttgtggcc actgggtatg tgtggctacc    720

gcgggtatgc gagtgccaga tattggctga gacgagccag cttagactaa ttggtacaag    780

gaaggcaaga aaacaaagac aaataaacag cggaagttat cagtatggag gggaagtgta    840

aacttaaagg gaccagactt tctaaatctt acaactcaag aggtggcagc caccctctag    900

gagacaaaac tacccccact gacaaggctt taggagaccc taaagtctgt tggctgtgac    960

gtcattatac ctaaaatctg catcatacct gcaagccaac agttcagtgt tttaacagag   1020

aaccaccctg ggaaacagaa gcagatctga tgtgtttcct atacatgtcc tgtgctcact   1080

ttattaaaaa ttcttttgca cacaatgttt atgaaaaggc cagatccttt tccaatactt   1140

atgcaaaagc aaaagaaaac cccgacacct cacctttcgc tgtttgttgt ttcatagatt   1200

tatttaaaaa aagagaaagt ctatagctat aaatctttaa agagaaatat gaatacaatt   1260

cccctaaact ctcctcaaaa gagaattcag tctacagcca tttaaatgat cattgctgct   1320

acagaagtgc tttaagagaa ttgcctgaaa catctgtatt atatcggcca cctgccaatc   1380

acagctttac tctttcaggt cactctgggg ctgcctcttg catgtattac taaataaaat   1440

gatctctctt tctctctctc tctctctttt ctaagaaaca attatgtgca ctttgataca   1500

caaccttctc taaccaacta tatatcaaga cccaaaaatt gaagaaaaat attgttttct   1560

catacagtga gcagattttt caatctacta attctgtgac ttgtcttggt gtgctagcct   1620

acaccttctc tttggtttag ttttcctttt ctataacact ctgaattgct aatcttacta   1680

acacctatga tgttacctga aatcaatctc ccatatgtat gctgtatgct atgctaagac   1740

tcctgaaata tacttactct gtgcttgtgt atgtgaatgt taatgcaact attacctaga   1800

gtgaacttta agctttattg ttgaatgtaa ttccattata tttccttttg tacacctgtg   1860

aaaaagtgga gtagtgtttt tttaaccatt gttaatcagc ttttgtgtat gaaagacaca   1920

gtaaaatttc tttcttaaat c                                             1941


<210>  2201
<211>  135
<212>  PRT
<213>  Homo sapiens

<400>  2201


Met Ala Phe Ser Pro Ser Leu Pro Leu Gly Leu Asn Lys Glu Glu Glu 
1               5                   10                  15      


Gly Glu Arg Gln Glu Pro Gly Ser Asn His Pro Gly Gln Pro Arg Gln 
            20                  25                  30          


Pro Asn Pro Asp Trp Arg Tyr Ser Ala Ser Leu Arg Ala Gly Met His 
        35                  40                  45              


Ser Ser Val His Leu Glu Glu Ala Gly Ile Leu Arg Ala Gly Pro Gly 
    50                  55                  60                  


Gly Pro Asp Gln Gln Trp Pro Thr Val Ser Ser Ala Thr Pro Glu Pro 
65                  70                  75                  80  


Glu Ala Gly Glu Val Ser Pro Pro Val Gly Ala Gly Val Asn Ser Asn 
                85                  90                  95      


Ser Trp Thr Phe Lys Tyr Gly Pro Gly Asn Pro Lys Gln Ser Gly Pro 
            100                 105                 110         


Glu Pro Lys Lys Gln Thr Gln Val Ser Phe Leu Leu Arg Arg Lys Gly 
        115                 120                 125             


Glu Ala Ser Gln Pro Arg Gln 
    130                 135 

<210>  2202
<211>  2709
<212>  DNA
<213>  Homo sapiens

<400>  2202
ggtgtccagc ctcctggtac tcacgctgct gctgtatacg gcgctgtggt ggtcggcaac     60

gcccactgag ggcgcgtgcg cgccggggaa gcccacgctg gtgtgctccc gcgcggtggg    120

gagctggtca tactcgcagc agaggcggca gagggtgtgc tctgaggagg gcccacctaa    180

gacggacctc atggccttca gccccagtct tcctctaggt ctgaataaag aggaggaagg    240

ggaaagacag gagccagggt caaatcaccc cggacagcca cgacagccca accctgactg    300

gcgttactct gcctccctga gagcaggcat gcacagctct gtgcacctag aggaggctgg    360

cattctacgg gctggtccag gagggcctga tcagcagtgg ccaacagtat ccagtgcaac    420

accagaacca gaggcaggag aagtgtcccc tccagtcggt gcgggtgtca acagcaacag    480

ctggaccttt aaatacggac caggcaaccc caaacaatcc ggtcccgaac ctaaaaagca    540

gacccaagtt tcctttctcc tccgccgcaa aggagaggct tcccagcccc gccagtgaga    600

ggttggactc tctgccctgt gctccgggga tcctgtcttg atgacacttg cagggcaggc    660

tgaaaagttt tgagattgag cagcttggga gtttgtggcc actgggtatg tgtggctacc    720

gcgggtatgc gagtgccaga tattggctga gacgagccag cttagactaa ttggtacaag    780

gaaggcaaga aaacaaagac aaataaacag cggaagttat cagtatggag gggaagtgta    840

aacttaaagg gaccagactt tctaaatctt acaactcaag aggtggcagc caccctctag    900

gagacaaaac tacccccact gacaaggctt taggagaccc taaagtctgt tggctgtgac    960

gtcattatac ctaaaatctg catcatacct gcaagccaac agttcagtgt tttaacagag   1020

aaccaccctg ggaaacagaa gcagatctga tgtgtttcct atacatgtcc tgtgctcact   1080

ttattaaaaa ttcttttgca cacaatgttt atgaaaaggc cagatccttt tccaatactt   1140

atgcaaaagc aaaagaaaac cccgacacct cacctttcgc tgtttgttgt ttcatagatt   1200

tatttaaaaa aagagaaagt ctatagctat aaatctttaa agagaaatat gaatacaatt   1260

cccctaaact ctcctcaaaa gagaattcag tctacagcca tttaaatgat cattgctgct   1320

acagaagtgc tttaagagaa ttgcctgaaa catctgtatt atatcggcca cctgccaatc   1380

acagctttac tctttcaggt cactctgggg ctgcctcttg catgtattac taaataaaat   1440

gatctctctt tctctctctc tctctctttt ctaagaaaca attatgtgca ctttgataca   1500

caaccttctc taaccaacta tatatcaaga cccaaaaatt gaagaaaaat attgttttct   1560

catacagtga gcagattttt caatctacta attctgtgac ttgtcttggt gtgctagcct   1620

acaccttctc tttggtttag ttttcctttt ctataacact ctgaattgct aatcttacta   1680

acacctatga tgttacctga aatcaatctc ccatatgtat gctgtatgct atgctaagac   1740

tcctgaaata tacttactct gtgcttgtgt atgtgaatgt taatgcaact attacctaga   1800

gtgaacttta agctttattg ttgaatgtaa ttccattata tttccttttg tacacctgtg   1860

aaaaagtgga gtagtgtttt tttaaccatt gttaatcagc ttttgtgtat gaaagacaca   1920

gtaaaatttc tttcttaaat caagatactg gtgattcaag gaattttatt tatggtccag   1980

ccaagagcca tctcgtgcca agacttctgc tggcaaggga atggataaag ctgttttgtt   2040

ctagtaacaa ttttggaatg aatactgaca atattccatg agggtgtgca agcacaaatt   2100

ttaccaatct gacctctttg aagttgcaga atgctttgaa attctaatgg tatctgaaat   2160

atcagctcat agaaagtaac aaaatttgct gtcaccttaa ataagacatt ttaattttgt   2220

tataatgtac aatttagaag tttgattaat tatattatct atttaggcat taatataaaa   2280

gaggtaggag tctgttattt aaaaaaagca ttaaatttaa aaaaaaactg tcttgtctac   2340

ttttagcttc attctcccat attttgaagg gtgtgtaact tcagctctgc aggattgcat   2400

ggggtaaaac ttgttaccaa cacatgtgaa ccattgctac attgtaggtt gtgatcattt   2460

tgccccactg aagcccatgt atctgacctt acgtgccttt tgaactagga gaatcgggct   2520

aatttattaa tgatgataat tataatgtat ctgtacagca ctttttacat ttgcgaagtg   2580

ctttccaatc catgttagtt actagttatt acagctgtaa ggataaaaca cgtcatgtgg   2640

attcattttg aattggtgct attggtattt cctctgttat tgctaataaa tgaaaatggt   2700

ggtatgaaa                                                           2709


<210>  2203
<211>  135
<212>  PRT
<213>  Homo sapiens

<400>  2203


Met Ala Phe Ser Pro Ser Leu Pro Leu Gly Leu Asn Lys Glu Glu Glu 
1               5                   10                  15      


Gly Glu Arg Gln Glu Pro Gly Ser Asn His Pro Gly Gln Pro Arg Gln 
            20                  25                  30          


Pro Asn Pro Asp Trp Arg Tyr Ser Ala Ser Leu Arg Ala Gly Met His 
        35                  40                  45              


Ser Ser Val His Leu Glu Glu Ala Gly Ile Leu Arg Ala Gly Pro Gly 
    50                  55                  60                  


Gly Pro Asp Gln Gln Trp Pro Thr Val Ser Ser Ala Thr Pro Glu Pro 
65                  70                  75                  80  


Glu Ala Gly Glu Val Ser Pro Pro Val Gly Ala Gly Val Asn Ser Asn 
                85                  90                  95      


Ser Trp Thr Phe Lys Tyr Gly Pro Gly Asn Pro Lys Gln Ser Gly Pro 
            100                 105                 110         


Glu Pro Lys Lys Gln Thr Gln Val Ser Phe Leu Leu Arg Arg Lys Gly 
        115                 120                 125             


Glu Ala Ser Gln Pro Arg Gln 
    130                 135 

<210>  2204
<211>  5407
<212>  DNA
<213>  Homo sapiens

<400>  2204
gcacccacat tccaatcatt cacggaatag gatcgactcc ataatgactg tgatgctgga     60

aaaaatttac taaatatgta cttacagaaa agggtgactg ctcataaaat acctcaggca    120

agcgatccct taaaactgat tgtcccaact cagaggccct cattttctgc aatggtgatt    180

atcggaccaa gaggcccggg atcccagcgt ctgctgctct cgcttctgct ccttgcagcc    240

tgggaggtgg ggagcggcca gctccactac tccgtctacg aggaggccaa acacggcacc    300

ttcgtgggcc gcatcgctca ggacctgggg ctggagctgg cggagctggt gccgcgcctg    360

ttccgggtgg cgtccaaaag acacggggac cttctggagg taaatctgca gaatggcatt    420

ttgtttgtga attctcggat cgaccgcgag aagctgtgcg ggcggagcgc ggagtgcagt    480

atccacctgg aggtgatcgt ggacaggccg ctgcaggttt tccatgtgga cgtggaggtg    540

aaggacatta acgacaaccc gccggtgttc agagaaaggg aacaaaaggt acctgtttct    600

gaatctgcgc ctctggactc tcattttcct ctagagggcg cttctgatgc ggatatcggc    660

gtaaactctc ttttgaccta tgcgttaagt ctaaatgaga attttgagct taaaataaaa    720

acaaaaaaag ataaaagtat attgcctgaa ttagttcttc ggaagttatt ggacagagag    780

caaacgccaa aactcaattt attgctgatg gtaatcgatg gcggtaaacc agaactaaca    840

gggtctgtcc agattcaaat aaccgtcctg gatgtgaatg acaatggtcc ggcgtttgat    900

aagcccagct ataaagtagt gttgtctgaa aatgtccaaa acgacacaag agtgatccaa    960

ctaaatgctt ccgatccaga cgaaggactt aatggagaaa tttcctatgg gatcaaaatg   1020

attttgccag tgagtgagaa atgtatgttt tcaataaatc cagacacagg tgaaattaga   1080

atttatggtg aactggattt tgaagagaat aatgcctatg aaattcaggt taacgccatt   1140

gataaaggga ttccttccat ggcaggtcac agcatggtcc tggtggaagt tctggacgtg   1200

aatgacaatg tccctgaagt aatggttact tcactgtcgc tccctgtgca agaggatgct   1260

caggtgggta ccgtcattgc cctgattagc gtgtcggatc gtgactctgg agccaatgga   1320

caggtcatct gctcactgac acctcatgtt cccttcaagc tggtgtccac ctacaagaat   1380

tactactcgt tggtgctgga cagcgccctg gaccgcgaga gcgtgtcggc ctatgagctg   1440

gtggtgactg cgcgggatgg gggctcgcct tcgctgtggg ccacggctag agtgtccgtg   1500

gaggtggccg acgtgaacga caatgcgcct gcgttcgcgc agcccgagta cacagtgttc   1560

gtgaaggaga acaacccgcc gggctgccac atcttcacgg tgtcggcatg ggacgcggac   1620

gcgcagaaga acgcgctggt gtcctactcg ctggtggagc ggcgggtggg cgagcacgca   1680

ctgtcgagct acgtgtcggt gcacgcggag agcggcaagg tgtacgcgct gcagccgcta   1740

gaccacgagg agctggagct gctgcagttc caggtgagcg cgcgcgacgc cggcgtgccg   1800

cctctgggca gcaacgtgac gctgcaggtg ttcgtgctgg acgagaacga caacgcgccg   1860

gcactgctgg cgactccggc tggcagcgca ggaggcgcag ttagcgagtt ggtaccgcgg   1920

tcggtgggtg cgggccacgt ggtggcgaaa gtgcgcgcgg tggacgctga ctccggctat   1980

aacgcttggc tgtcctacga gttgcaaccg gcggcggtcg gcgcgcacat cccgttccac   2040

gtggggctgt acactggcga gatcagcacg acacgcatcc tggatgaggc ggacgctccg   2100

cgccaccgcc tgctggtgct ggtgaaggac cacggtgagc ccgcgctgac gtccacggcc   2160

acggtgctgg tgtcgctggt ggagaacggc caggccccaa agacgtcgtc gcgggcctca   2220

gtgggcgctg tggatcccga agcggctctg gtggatatta acgtgtacct catcatcgcc   2280

atctgtgcgg tgtccagcct gctggtgctc acgctgctgc tgtacactgc gctgcgttgc   2340

tcagcgccgc ccaccgtgag ccggtgcgcg ccgggcaagc ccacgctggt gtgctccagc   2400

gccgtgggga gttggtctta ctcgcagcag aggaggcaga gggtgtgctc tgcagagagc   2460

ccgcccaaga cggacctcat ggccttcagc ccaagccttc agctgtctcg agaagattgt   2520

ttaaatcctc ccagtgaacc acgacagccc aaccctgact ggcgttactc tgcctccctg   2580

agagcaggca tgcacagctc tgtgcaccta gaggaggctg gcattctacg ggctggtcca   2640

ggagggcctg atcagcagtg gccaacagta tccagtgcaa caccagaacc agaggcagga   2700

gaagtgtccc ctccagtcgg tgcgggtgtc aacagcaaca gctggacctt taaatacgga   2760

ccaggcaacc ccaaacaatc cggtcccggt gagttgcccg acaaattcat tatcccagga   2820

tctcctgcaa tcatctccat ccggcaggag cctactaaca gccaaattga caaaagtgac   2880

ttcataacct tcggcaaaaa ggaggagacc aagaaaaaga agaaaaagaa gaagggtaac   2940

aagacccagg agaaaaaaga gaaagggaac agcacgactg acaacagtga ccagtgaggt   3000

cctcaaatgg aaacaagcca cttagccagt ttttgtaata atggcaaatc tctcccatgt   3060

agcaattccc tgctcctttt tcctatctac atgagccctc ttagagacct cagaaatctg   3120

cagaaagttc cctgtgtctg tctagaacgc atttaacagg ttttgtcgta aaagctttac   3180

taagtctggt gttaactctt tctctccact ctggcttgtt ttcagaacct aaaaagcaga   3240

cccaagtttc ctttctcctc cgccgcaaag gagaggcttc ccagccccgc cagtgagagg   3300

ttggactctc tgccctgtgc tccggggatc ctgtcttgat gacacttgca gggcaggctg   3360

aaaagttttg agattgagca gcttgggagt ttgtggccac tgggtatgtg tggctaccgc   3420

gggtatgcga gtgccagata ttggctgaga cgagccagct tagactaatt ggtacaagga   3480

aggcaagaaa acaaagacaa ataaacagcg gaagttatca gtatggaggg gaagtgtaaa   3540

cttaaaggga ccagactttc taaatcttac aactcaagag gtggcagcca ccctctagga   3600

gacaaaacta cccccactga caaggcttta ggagacccta aagtctgttg gctgtgacgt   3660

cattatacct aaaatctgca tcatacctgc aagccaacag ttcagtgttt taacagagaa   3720

ccaccctggg aaacagaagc agatctgatg tgtttcctat acatgtcctg tgctcacttt   3780

attaaaaatt cttttgcaca caatgtttat gaaaaggcca gatccttttc caatacttat   3840

gcaaaagcaa aagaaaaccc cgacacctca cctttcgctg tttgttgttt catagattta   3900

tttaaaaaaa gagaaagtct atagctataa atctttaaag agaaatatga atacaattcc   3960

cctaaactct cctcaaaaga gaattcagtc tacagccatt taaatgatca ttgctgctac   4020

agaagtgctt taagagaatt gcctgaaaca tctgtattat atcggccacc tgccaatcac   4080

agctttactc tttcaggtca ctctggggct gcctcttgca tgtattacta aataaaatga   4140

tctctctttc tctctctctc tctcttttct aagaaacaat tatgtgcact ttgatacaca   4200

accttctcta accaactata tatcaagacc caaaaattga agaaaaatat tgttttctca   4260

tacagtgagc agatttttca atctactaat tctgtgactt gtcttggtgt gctagcctac   4320

accttctctt tggtttagtt ttccttttct ataacactct gaattgctaa tcttactaac   4380

acctatgatg ttacctgaaa tcaatctccc atatgtatgc tgtatgctat gctaagactc   4440

ctgaaatata cttactctgt gcttgtgtat gtgaatgtta atgcaactat tacctagagt   4500

gaactttaag ctttattgtt gaatgtaatt ccattatatt tccttttgta cacctgtgaa   4560

aaagtggagt agtgtttttt taaccattgt taatcagctt ttgtgtatga aagacacagt   4620

aaaatttctt tcttaaatca agatactggt gattcaagga attttattta tggtccagcc   4680

aagagccatc tcgtgccaag acttctgctg gcaagggaat ggataaagct gttttgttct   4740

agtaacaatt ttggaatgaa tactgacaat attccatgag ggtgtgcaag cacaaatttt   4800

accaatctga cctctttgaa gttgcagaat gctttgaaat tctaatggta tctgaaatat   4860

cagctcatag aaagtaacaa aatttgctgt caccttaaat aagacatttt aattttgtta   4920

taatgtacaa tttagaagtt tgattaatta tattatctat ttaggcatta atataaaaga   4980

ggtaggagtc tgttatttaa aaaaagcatt aaatttaaaa aaaaactgtc ttgtctactt   5040

ttagcttcat tctcccatat tttgaagggt gtgtaacttc agctctgcag gattgcatgg   5100

ggtaaaactt gttaccaaca catgtgaacc attgctacat tgtaggttgt gatcattttg   5160

ccccactgaa gcccatgtat ctgaccttac gtgccttttg aactaggaga atcgggctaa   5220

tttattaatg atgataatta taatgtatct gtacagcact ttttacattt gcgaagtgct   5280

ttccaatcca tgttagttac tagttattac agctgtaagg ataaaacacg tcatgtggat   5340

tcattttgaa ttggtgctat tggtatttcc tctgttattg ctaataaatg aaaatggtgg   5400

tatgaaa                                                             5407


<210>  2205
<211>  973
<212>  PRT
<213>  Homo sapiens

<400>  2205


Met Tyr Leu Gln Lys Arg Val Thr Ala His Lys Ile Pro Gln Ala Ser 
1               5                   10                  15      


Asp Pro Leu Lys Leu Ile Val Pro Thr Gln Arg Pro Ser Phe Ser Ala 
            20                  25                  30          


Met Val Ile Ile Gly Pro Arg Gly Pro Gly Ser Gln Arg Leu Leu Leu 
        35                  40                  45              


Ser Leu Leu Leu Leu Ala Ala Trp Glu Val Gly Ser Gly Gln Leu His 
    50                  55                  60                  


Tyr Ser Val Tyr Glu Glu Ala Lys His Gly Thr Phe Val Gly Arg Ile 
65                  70                  75                  80  


Ala Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Pro Arg Leu Phe 
                85                  90                  95      


Arg Val Ala Ser Lys Arg His Gly Asp Leu Leu Glu Val Asn Leu Gln 
            100                 105                 110         


Asn Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Lys Leu Cys 
        115                 120                 125             


Gly Arg Ser Ala Glu Cys Ser Ile His Leu Glu Val Ile Val Asp Arg 
    130                 135                 140                 


Pro Leu Gln Val Phe His Val Asp Val Glu Val Lys Asp Ile Asn Asp 
145                 150                 155                 160 


Asn Pro Pro Val Phe Arg Glu Arg Glu Gln Lys Val Pro Val Ser Glu 
                165                 170                 175     


Ser Ala Pro Leu Asp Ser His Phe Pro Leu Glu Gly Ala Ser Asp Ala 
            180                 185                 190         


Asp Ile Gly Val Asn Ser Leu Leu Thr Tyr Ala Leu Ser Leu Asn Glu 
        195                 200                 205             


Asn Phe Glu Leu Lys Ile Lys Thr Lys Lys Asp Lys Ser Ile Leu Pro 
    210                 215                 220                 


Glu Leu Val Leu Arg Lys Leu Leu Asp Arg Glu Gln Thr Pro Lys Leu 
225                 230                 235                 240 


Asn Leu Leu Leu Met Val Ile Asp Gly Gly Lys Pro Glu Leu Thr Gly 
                245                 250                 255     


Ser Val Gln Ile Gln Ile Thr Val Leu Asp Val Asn Asp Asn Gly Pro 
            260                 265                 270         


Ala Phe Asp Lys Pro Ser Tyr Lys Val Val Leu Ser Glu Asn Val Gln 
        275                 280                 285             


Asn Asp Thr Arg Val Ile Gln Leu Asn Ala Ser Asp Pro Asp Glu Gly 
    290                 295                 300                 


Leu Asn Gly Glu Ile Ser Tyr Gly Ile Lys Met Ile Leu Pro Val Ser 
305                 310                 315                 320 


Glu Lys Cys Met Phe Ser Ile Asn Pro Asp Thr Gly Glu Ile Arg Ile 
                325                 330                 335     


Tyr Gly Glu Leu Asp Phe Glu Glu Asn Asn Ala Tyr Glu Ile Gln Val 
            340                 345                 350         


Asn Ala Ile Asp Lys Gly Ile Pro Ser Met Ala Gly His Ser Met Val 
        355                 360                 365             


Leu Val Glu Val Leu Asp Val Asn Asp Asn Val Pro Glu Val Met Val 
    370                 375                 380                 


Thr Ser Leu Ser Leu Pro Val Gln Glu Asp Ala Gln Val Gly Thr Val 
385                 390                 395                 400 


Ile Ala Leu Ile Ser Val Ser Asp Arg Asp Ser Gly Ala Asn Gly Gln 
                405                 410                 415     


Val Ile Cys Ser Leu Thr Pro His Val Pro Phe Lys Leu Val Ser Thr 
            420                 425                 430         


Tyr Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu 
        435                 440                 445             


Ser Val Ser Ala Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser 
    450                 455                 460                 


Pro Ser Leu Trp Ala Thr Ala Arg Val Ser Val Glu Val Ala Asp Val 
465                 470                 475                 480 


Asn Asp Asn Ala Pro Ala Phe Ala Gln Pro Glu Tyr Thr Val Phe Val 
                485                 490                 495     


Lys Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Trp 
            500                 505                 510         


Asp Ala Asp Ala Gln Lys Asn Ala Leu Val Ser Tyr Ser Leu Val Glu 
        515                 520                 525             


Arg Arg Val Gly Glu His Ala Leu Ser Ser Tyr Val Ser Val His Ala 
    530                 535                 540                 


Glu Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu 
545                 550                 555                 560 


Glu Leu Leu Gln Phe Gln Val Ser Ala Arg Asp Ala Gly Val Pro Pro 
                565                 570                 575     


Leu Gly Ser Asn Val Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp 
            580                 585                 590         


Asn Ala Pro Ala Leu Leu Ala Thr Pro Ala Gly Ser Ala Gly Gly Ala 
        595                 600                 605             


Val Ser Glu Leu Val Pro Arg Ser Val Gly Ala Gly His Val Val Ala 
    610                 615                 620                 


Lys Val Arg Ala Val Asp Ala Asp Ser Gly Tyr Asn Ala Trp Leu Ser 
625                 630                 635                 640 


Tyr Glu Leu Gln Pro Ala Ala Val Gly Ala His Ile Pro Phe His Val 
                645                 650                 655     


Gly Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Ile Leu Asp Glu Ala 
            660                 665                 670         


Asp Ala Pro Arg His Arg Leu Leu Val Leu Val Lys Asp His Gly Glu 
        675                 680                 685             


Pro Ala Leu Thr Ser Thr Ala Thr Val Leu Val Ser Leu Val Glu Asn 
    690                 695                 700                 


Gly Gln Ala Pro Lys Thr Ser Ser Arg Ala Ser Val Gly Ala Val Asp 
705                 710                 715                 720 


Pro Glu Ala Ala Leu Val Asp Ile Asn Val Tyr Leu Ile Ile Ala Ile 
                725                 730                 735     


Cys Ala Val Ser Ser Leu Leu Val Leu Thr Leu Leu Leu Tyr Thr Ala 
            740                 745                 750         


Leu Arg Cys Ser Ala Pro Pro Thr Val Ser Arg Cys Ala Pro Gly Lys 
        755                 760                 765             


Pro Thr Leu Val Cys Ser Ser Ala Val Gly Ser Trp Ser Tyr Ser Gln 
    770                 775                 780                 


Gln Arg Arg Gln Arg Val Cys Ser Ala Glu Ser Pro Pro Lys Thr Asp 
785                 790                 795                 800 


Leu Met Ala Phe Ser Pro Ser Leu Gln Leu Ser Arg Glu Asp Cys Leu 
                805                 810                 815     


Asn Pro Pro Ser Glu Pro Arg Gln Pro Asn Pro Asp Trp Arg Tyr Ser 
            820                 825                 830         


Ala Ser Leu Arg Ala Gly Met His Ser Ser Val His Leu Glu Glu Ala 
        835                 840                 845             


Gly Ile Leu Arg Ala Gly Pro Gly Gly Pro Asp Gln Gln Trp Pro Thr 
    850                 855                 860                 


Val Ser Ser Ala Thr Pro Glu Pro Glu Ala Gly Glu Val Ser Pro Pro 
865                 870                 875                 880 


Val Gly Ala Gly Val Asn Ser Asn Ser Trp Thr Phe Lys Tyr Gly Pro 
                885                 890                 895     


Gly Asn Pro Lys Gln Ser Gly Pro Gly Glu Leu Pro Asp Lys Phe Ile 
            900                 905                 910         


Ile Pro Gly Ser Pro Ala Ile Ile Ser Ile Arg Gln Glu Pro Thr Asn 
        915                 920                 925             


Ser Gln Ile Asp Lys Ser Asp Phe Ile Thr Phe Gly Lys Lys Glu Glu 
    930                 935                 940                 


Thr Lys Lys Lys Lys Lys Lys Lys Lys Gly Asn Lys Thr Gln Glu Lys 
945                 950                 955                 960 


Lys Glu Lys Gly Asn Ser Thr Thr Asp Asn Ser Asp Gln 
                965                 970             

<210>  2206
<211>  3628
<212>  DNA
<213>  Homo sapiens

<400>  2206
atcaaaatga ttttgccagt gagtgagaaa tgtatgtttt caataaatcc agacacaggt     60

gaaattagaa tttatggtga actggatttt gaagagaata atgcctatga aattcaggtt    120

aacgccattg ataaagggat tccttccatg gcaggtcaca gcatggtcct ggtggaagtt    180

ctggacgtga atgacaatgt ccctgaagta atggttactt cactgtcgct ccctgtgcaa    240

gaggatgctc aggtgggtac cgtcattgcc ctgattagcg tgtcggatcg tgactctgga    300

gccaatggac aggtcatctg ctcactgaca cctcatgttc ccttcaagct ggtgtccacc    360

tacaagaatt actactcgtt ggtgctggac agcgccctgg accgcgagag cgtgtcggcc    420

tatgagctgg tggtgactgc gcgggatggg ggctcgcctt cgctgtgggc cacggctaga    480

gtgtccgtgg aggtggccga cgtgaacgac aatgcgcctg cgttcgcgca gcccgagtac    540

acagtgttcg tgaaggagaa caacccgccg ggctgccaca tcttcacggt gtcggcatgg    600

gacgcggacg cgcagaagaa cgcgctggtg tcctactcgc tggtggagcg gcgggtgggc    660

gagcacgcac tgtcgagcta cgtgtcggtg cacgcggaga gcggcaaggt gtacgcgctg    720

cagccgctag accacgagga gctggagctg ctgcagttcc aggtgagcgc gcgcgacgcc    780

ggcgtgccgc ctctgggcag caacgtgacg ctgcaggtgt tcgtgctgga cgagaacgac    840

aacgcgccgg cactgctggc gactccggct ggcagcgcag gaggcgcagt tagcgagttg    900

gtaccgcggt cggtgggtgc gggccacgtg gtggcgaaag tgcgcgcggt ggacgctgac    960

tccggctata acgcttggct gtcctacgag ttgcaaccgg cggcggtcgg cgcgcacatc   1020

ccgttccacg tggggctgta cactggcgag atcagcacga cacgcatcct ggatgaggcg   1080

gacgctccgc gccaccgcct gctggtgctg gtgaaggacc acggtgagcc cgcgctgacg   1140

tccacggcca cggtgctggt gtcgctggtg gagaacggcc aggccccaaa gacgtcgtcg   1200

cgggcctcag tgggcgctgt ggatcccgaa gcggctctgg tggatattaa cgtgtacctc   1260

atcatcgcca tctgtgcggt gtccagcctg ctggtgctca cgctgctgct gtacactgcg   1320

ctgcgttgct cagcgccgcc caccgtgagc cggtgcgcgc cgggcaagcc cacgctggtg   1380

tgctccagcg ccgtggggag ttggtcttac tcgcagcaga ggaggcagag ggtgtgctct   1440

gcagagagcc cgcccaagac ggacctcatg gccttcagcc caagccttca gctgtctcga   1500

gaagattgtt taaatcctcc cagtgaacca cgacagccca accctgactg gcgttactct   1560

gcctccctga gagcaggcat gcacagctct gtgcacctag aggaggctgg cattctacgg   1620

gctggtccag gagggcctga tcagcagtgg ccaacagtat ccagtgcaac accagaacca   1680

gaggcaggag aagtgtcccc tccagtcggt gcgggtgtca acagcaacag ctggaccttt   1740

aaatacggac caggcaaccc caaacaatcc ggtcccggtg agttgcccga caaattcatt   1800

atcccaggat ctcctgcaat catctccatc cggcaggagc ctactaacag ccaaattgac   1860

aaaagtgact tcataacctt cggcaaaaag gaggagacca agaaaaagaa gaaaaagaag   1920

aagggtaaca agacccagga gaaaaaagag aaagggaaca gcacgactga caacagtgac   1980

cagtgaggtc ctcaaatgga aacaagccac ttagccagtt tttgtaataa tggcaaatct   2040

ctcccatgta gcaattccct gctccttttt cctatctaca tgagccctct tagagacctc   2100

agaaatctgc agaaagttcc ctgtgtctgt ctagaacgca tttaacaggt tttgtcgtaa   2160

aagctttact aagtctggtg ttaactcttt ctctccactc tggcttgttt tcagaaccta   2220

aaaagcagac ccaagtttcc tttctcctcc gccgcaaagg agaggcttcc cagccccgcc   2280

agtgagaggt tggactctct gccctgtgct ccggggatcc tgtcttgatg acacttgcag   2340

ggcaggctga aaagttttga gattgagcag cttgggagtt tgtggccact gggtatgtgt   2400

ggctaccgcg ggtatgcgag tgccagatat tggctgagac gagccagctt agactaattg   2460

gtacaaggaa ggcaagaaaa caaagacaaa taaacagcgg aagttatcag tatggagggg   2520

aagtgtaaac ttaaagggac cagactttct aaatcttaca actcaagagg tggcagccac   2580

cctctaggag acaaaactac ccccactgac aaggctttag gagaccctaa agtctgttgg   2640

ctgtgacgtc attataccta aaatctgcat catacctgca agccaacagt tcagtgtttt   2700

aacagagaac caccctggga aacagaagca gatctgatgt gtttcctata catgtcctgt   2760

gctcacttta ttaaaaattc ttttgcacac aatgtttatg aaaaggccag atccttttcc   2820

aatacttatg caaaagcaaa agaaaacccc gacacctcac ctttcgctgt ttgttgtttc   2880

atagatttat ttaaaaaaag agaaagtcta tagctataaa tctttaaaga gaaatatgaa   2940

tacaattccc ctaaactctc ctcaaaagag aattcagtct acagccattt aaatgatcat   3000

tgctgctaca gaagtgcttt aagagaattg cctgaaacat ctgtattata tcggccacct   3060

gccaatcaca gctttactct ttcaggtcac tctggggctg cctcttgcat gtattactaa   3120

ataaaatgat ctctctttct ctctctctct ctcttttcta agaaacaatt atgtgcactt   3180

tgatacacaa ccttctctaa ccaactatat atcaagaccc aaaaattgaa gaaaaatatt   3240

gttttctcat acagtgagca gatttttcaa tctactaatt ctgtgacttg tcttggtgtg   3300

ctagcctaca ccttctcttt ggtttagttt tccttttcta taacactctg aattgctaat   3360

cttactaaca cctatgatgt tacctgaaat caatctccca tatgtatgct gtatgctatg   3420

ctaagactcc tgaaatatac ttactctgtg cttgtgtatg tgaatgttaa tgcaactatt   3480

acctagagtg aactttaagc tttattgttg aatgtaattc cattatattt ccttttgtac   3540

acctgtgaaa aagtggagta gtgttttttt aaccattgtt aatcagcttt tgtgtatgaa   3600

agacacagta aaatttcttt cttaaatc                                      3628


<210>  2207
<211>  659
<212>  PRT
<213>  Homo sapiens

<400>  2207


Met Ile Leu Pro Val Ser Glu Lys Cys Met Phe Ser Ile Asn Pro Asp 
1               5                   10                  15      


Thr Gly Glu Ile Arg Ile Tyr Gly Glu Leu Asp Phe Glu Glu Asn Asn 
            20                  25                  30          


Ala Tyr Glu Ile Gln Val Asn Ala Ile Asp Lys Gly Ile Pro Ser Met 
        35                  40                  45              


Ala Gly His Ser Met Val Leu Val Glu Val Leu Asp Val Asn Asp Asn 
    50                  55                  60                  


Val Pro Glu Val Met Val Thr Ser Leu Ser Leu Pro Val Gln Glu Asp 
65                  70                  75                  80  


Ala Gln Val Gly Thr Val Ile Ala Leu Ile Ser Val Ser Asp Arg Asp 
                85                  90                  95      


Ser Gly Ala Asn Gly Gln Val Ile Cys Ser Leu Thr Pro His Val Pro 
            100                 105                 110         


Phe Lys Leu Val Ser Thr Tyr Lys Asn Tyr Tyr Ser Leu Val Leu Asp 
        115                 120                 125             


Ser Ala Leu Asp Arg Glu Ser Val Ser Ala Tyr Glu Leu Val Val Thr 
    130                 135                 140                 


Ala Arg Asp Gly Gly Ser Pro Ser Leu Trp Ala Thr Ala Arg Val Ser 
145                 150                 155                 160 


Val Glu Val Ala Asp Val Asn Asp Asn Ala Pro Ala Phe Ala Gln Pro 
                165                 170                 175     


Glu Tyr Thr Val Phe Val Lys Glu Asn Asn Pro Pro Gly Cys His Ile 
            180                 185                 190         


Phe Thr Val Ser Ala Trp Asp Ala Asp Ala Gln Lys Asn Ala Leu Val 
        195                 200                 205             


Ser Tyr Ser Leu Val Glu Arg Arg Val Gly Glu His Ala Leu Ser Ser 
    210                 215                 220                 


Tyr Val Ser Val His Ala Glu Ser Gly Lys Val Tyr Ala Leu Gln Pro 
225                 230                 235                 240 


Leu Asp His Glu Glu Leu Glu Leu Leu Gln Phe Gln Val Ser Ala Arg 
                245                 250                 255     


Asp Ala Gly Val Pro Pro Leu Gly Ser Asn Val Thr Leu Gln Val Phe 
            260                 265                 270         


Val Leu Asp Glu Asn Asp Asn Ala Pro Ala Leu Leu Ala Thr Pro Ala 
        275                 280                 285             


Gly Ser Ala Gly Gly Ala Val Ser Glu Leu Val Pro Arg Ser Val Gly 
    290                 295                 300                 


Ala Gly His Val Val Ala Lys Val Arg Ala Val Asp Ala Asp Ser Gly 
305                 310                 315                 320 


Tyr Asn Ala Trp Leu Ser Tyr Glu Leu Gln Pro Ala Ala Val Gly Ala 
                325                 330                 335     


His Ile Pro Phe His Val Gly Leu Tyr Thr Gly Glu Ile Ser Thr Thr 
            340                 345                 350         


Arg Ile Leu Asp Glu Ala Asp Ala Pro Arg His Arg Leu Leu Val Leu 
        355                 360                 365             


Val Lys Asp His Gly Glu Pro Ala Leu Thr Ser Thr Ala Thr Val Leu 
    370                 375                 380                 


Val Ser Leu Val Glu Asn Gly Gln Ala Pro Lys Thr Ser Ser Arg Ala 
385                 390                 395                 400 


Ser Val Gly Ala Val Asp Pro Glu Ala Ala Leu Val Asp Ile Asn Val 
                405                 410                 415     


Tyr Leu Ile Ile Ala Ile Cys Ala Val Ser Ser Leu Leu Val Leu Thr 
            420                 425                 430         


Leu Leu Leu Tyr Thr Ala Leu Arg Cys Ser Ala Pro Pro Thr Val Ser 
        435                 440                 445             


Arg Cys Ala Pro Gly Lys Pro Thr Leu Val Cys Ser Ser Ala Val Gly 
    450                 455                 460                 


Ser Trp Ser Tyr Ser Gln Gln Arg Arg Gln Arg Val Cys Ser Ala Glu 
465                 470                 475                 480 


Ser Pro Pro Lys Thr Asp Leu Met Ala Phe Ser Pro Ser Leu Gln Leu 
                485                 490                 495     


Ser Arg Glu Asp Cys Leu Asn Pro Pro Ser Glu Pro Arg Gln Pro Asn 
            500                 505                 510         


Pro Asp Trp Arg Tyr Ser Ala Ser Leu Arg Ala Gly Met His Ser Ser 
        515                 520                 525             


Val His Leu Glu Glu Ala Gly Ile Leu Arg Ala Gly Pro Gly Gly Pro 
    530                 535                 540                 


Asp Gln Gln Trp Pro Thr Val Ser Ser Ala Thr Pro Glu Pro Glu Ala 
545                 550                 555                 560 


Gly Glu Val Ser Pro Pro Val Gly Ala Gly Val Asn Ser Asn Ser Trp 
                565                 570                 575     


Thr Phe Lys Tyr Gly Pro Gly Asn Pro Lys Gln Ser Gly Pro Gly Glu 
            580                 585                 590         


Leu Pro Asp Lys Phe Ile Ile Pro Gly Ser Pro Ala Ile Ile Ser Ile 
        595                 600                 605             


Arg Gln Glu Pro Thr Asn Ser Gln Ile Asp Lys Ser Asp Phe Ile Thr 
    610                 615                 620                 


Phe Gly Lys Lys Glu Glu Thr Lys Lys Lys Lys Lys Lys Lys Lys Gly 
625                 630                 635                 640 


Asn Lys Thr Gln Glu Lys Lys Glu Lys Gly Asn Ser Thr Thr Asp Asn 
                645                 650                 655     


Ser Asp Gln 
            

<210>  2208
<211>  4887
<212>  DNA
<213>  Homo sapiens

<400>  2208
gacagtttga ggtaaggcgt tgtatatatt gcagatagct ctgaggtttt tggagtgtac     60

catgctgtct tcctggcaag gaggcccaag accgcggcaa ctactgctct ggcttctgat    120

cctcgcagcc tgggagacgg gtagtggcca gctccactac tccgtccccg aggaagcaaa    180

acacggcacc ttcgtgggcc gcatcgctca ggacctgggg ctggagctgg cggagctggt    240

gccgcgcctg ttccgggtgg cgtccaaaag acacggggac cttctggagg taaatctgca    300

gaatggcatt ttgtttgtga attctcggat cgaccgcgag gagctgtgtg ggcggagcgc    360

ggagtgcagc atccacctgg aggtgatcgt ggacaggcct ctgcaggttt tccatgtgga    420

ggtgaaggtg agggacatta acgacaaccc gcccatattc cctgaaagca agaaacgaat    480

aatcattgca gaatctagac ctccggaaac tcgatttcca ctagatggcg catccgatgc    540

agatattgga gtaaactcgg cattgaccta ccgactggat cccaacgatt atttcacttt    600

ggacgcacaa aacagtcttg agcaaatgtc ttcattatca cttgtactga ggaaaacact    660

ggacagagag gaaattcagg aacatagttt attactgaca gccagtgatg gaggtaaacc    720

cgagctgact ggcacagttc agctgctcat cacgattctg gacgtgaatg acaacgcccc    780

ggaattttac caatccgttt ataaagtgac ggtgttagag aacgccttca atggaacatt    840

agtgatcaag ctaaatgcca cagatcctga tgatggtaca aatggagata tagtttactc    900

atttagaagg cctgtatggc ctgcagtggt atatgcattt accataaatc cgaacaatgg    960

agaaattagg acaaaaggca aactagattt cgaagaaaag aaattatatg aaatatccgt   1020

ggaggcagtt gacaaaggaa atattccaat ggcgggtcat tgtacccttt tggtggaagt   1080

actagatgta aatgataacg ccccagaggt taccatcact tctttgtcac tccccatcag   1140

agaagacact cagcctagcg ccattattgc cctaatcagt gtgtccgatc gtgactctgg   1200

ctcaaatgga caggtcacct gcaccttgac gccgcatgtc cccttcaagc tggtgtccac   1260

ctacaagaac tactactcat tagtgctgga cagcgccctg gaccgcgaga gcgtatcagc   1320

ctatgaactg gtggtgaccg cgcgggacgg gggctcgcct tcgctgtggg ccacggccag   1380

cgtgtcggtg ggggtggccg acgtgaacga caacgcgccg gcgttcgcgc agcccgagta   1440

cacggtgttc gtgaaggaaa acaatccgcc gggctgccac atcttcacgg tgtctgctca   1500

ggacgcggac gcacaggaga acgcgctggt ctcctactcg ctggtggagc ggcgggtggg   1560

cgagcgtgcg ctgtcgagct acgtgtcggt gcacgcggag agcggcaagg tgtacgcgct   1620

gcagccgttg gaccacgagg agctggagct gttgcagttc caggtgagcg cgcgcgactc   1680

tggcgtgccg cctctgggca gcaacgtgac gctgcaggtg ttcgtgctgg acgagaacga   1740

caacgctccg gcgctgctga cgcccggggc tggcagcgcg ggaggcacag tgagcgagct   1800

gatgccgcgg tcggtgggtg caggccacgt ggtggcgaag gtgcgcgcgg tggacgccga   1860

ttcgggctac aatgcgtggc tttcgtatga attgcagctg gcggcggtcg gcgcgcgcat   1920

cccgttccgc gtggggctgt acactggcga gatcagcacg acgcgccctc tggacgaggt   1980

ggacgcgccg caccaccgcc ttctggtgct ggtgaaggac cacggtgagc ccgcgctgac   2040

ggccacggca acggtgctgt tgtcgctggt ggagagcggc caagcgccac aggcttcgtc   2100

gagggcgtcg gcaggcgctg tgggtccaga agcggcgctg gtggatgtca atgtttactt   2160

gatcattgcc atctgcgcgg tgtccagcct gttggtgctc acgttgctgc tgtatactgc   2220

gctgcggtgc tcggcaccgc ccaccgaggg cgcgtgcgcg ccgggcaagc ccactctagt   2280

gtgctccagc gcggcaggga gttggtcgta ctcgcagcag aggcggccga gggtgtgctc   2340

tggggagggc ccgcataaga cggacctcat ggccttcagt cccagccttc ctccttgtct   2400

gggttctgca gagggaacag gccagaggga ggaggactca gaatgcttga aagagccacg   2460

acagcccaac cctgactggc gttactctgc ctccctgaga gcaggcatgc acagctctgt   2520

gcacctagag gaggctggca ttctacgggc tggtccagga gggcctgatc agcagtggcc   2580

aacagtatcc agtgcaacac cagaaccaga ggcaggagaa gtgtcccctc cagtcggtgc   2640

gggtgtcaac agcaacagct ggacctttaa atacggacca ggcaacccca aacaatccgg   2700

tcccgaacct aaaaagcaga cccaagtttc ctttctcctc cgccgcaaag gagaggcttc   2760

ccagccccgc cagtgagagg ttggactctc tgccctgtgc tccggggatc ctgtcttgat   2820

gacacttgca gggcaggctg aaaagttttg agattgagca gcttgggagt ttgtggccac   2880

tgggtatgtg tggctaccgc gggtatgcga gtgccagata ttggctgaga cgagccagct   2940

tagactaatt ggtacaagga aggcaagaaa acaaagacaa ataaacagcg gaagttatca   3000

gtatggaggg gaagtgtaaa cttaaaggga ccagactttc taaatcttac aactcaagag   3060

gtggcagcca ccctctagga gacaaaacta cccccactga caaggcttta ggagacccta   3120

aagtctgttg gctgtgacgt cattatacct aaaatctgca tcatacctgc aagccaacag   3180

ttcagtgttt taacagagaa ccaccctggg aaacagaagc agatctgatg tgtttcctat   3240

acatgtcctg tgctcacttt attaaaaatt cttttgcaca caatgtttat gaaaaggcca   3300

gatccttttc caatacttat gcaaaagcaa aagaaaaccc cgacacctca cctttcgctg   3360

tttgttgttt catagattta tttaaaaaaa gagaaagtct atagctataa atctttaaag   3420

agaaatatga atacaattcc cctaaactct cctcaaaaga gaattcagtc tacagccatt   3480

taaatgatca ttgctgctac agaagtgctt taagagaatt gcctgaaaca tctgtattat   3540

atcggccacc tgccaatcac agctttactc tttcaggtca ctctggggct gcctcttgca   3600

tgtattacta aataaaatga tctctctttc tctctctctc tctcttttct aagaaacaat   3660

tatgtgcact ttgatacaca accttctcta accaactata tatcaagacc caaaaattga   3720

agaaaaatat tgttttctca tacagtgagc agatttttca atctactaat tctgtgactt   3780

gtcttggtgt gctagcctac accttctctt tggtttagtt ttccttttct ataacactct   3840

gaattgctaa tcttactaac acctatgatg ttacctgaaa tcaatctccc atatgtatgc   3900

tgtatgctat gctaagactc ctgaaatata cttactctgt gcttgtgtat gtgaatgtta   3960

atgcaactat tacctagagt gaactttaag ctttattgtt gaatgtaatt ccattatatt   4020

tccttttgta cacctgtgaa aaagtggagt agtgtttttt taaccattgt taatcagctt   4080

ttgtgtatga aagacacagt aaaatttctt tcttaaatca agatactggt gattcaagga   4140

attttattta tggtccagcc aagagccatc tcgtgccaag acttctgctg gcaagggaat   4200

ggataaagct gttttgttct agtaacaatt ttggaatgaa tactgacaat attccatgag   4260

ggtgtgcaag cacaaatttt accaatctga cctctttgaa gttgcagaat gctttgaaat   4320

tctaatggta tctgaaatat cagctcatag aaagtaacaa aatttgctgt caccttaaat   4380

aagacatttt aattttgtta taatgtacaa tttagaagtt tgattaatta tattatctat   4440

ttaggcatta atataaaaga ggtaggagtc tgttatttaa aaaaagcatt aaatttaaaa   4500

aaaaactgtc ttgtctactt ttagcttcat tctcccatat tttgaagggt gtgtaacttc   4560

agctctgcag gattgcatgg ggtaaaactt gttaccaaca catgtgaacc attgctacat   4620

tgtaggttgt gatcattttg ccccactgaa gcccatgtat ctgaccttac gtgccttttg   4680

aactaggaga atcgggctaa tttattaatg atgataatta taatgtatct gtacagcact   4740

ttttacattt gcgaagtgct ttccaatcca tgttagttac tagttattac agctgtaagg   4800

ataaaacacg tcatgtggat tcattttgaa ttggtgctat tggtatttcc tctgttattg   4860

ctaataaatg aaaatggtgg tatgaaa                                       4887


<210>  2209
<211>  904
<212>  PRT
<213>  Homo sapiens

<400>  2209


Met Leu Ser Ser Trp Gln Gly Gly Pro Arg Pro Arg Gln Leu Leu Leu 
1               5                   10                  15      


Trp Leu Leu Ile Leu Ala Ala Trp Glu Thr Gly Ser Gly Gln Leu His 
            20                  25                  30          


Tyr Ser Val Pro Glu Glu Ala Lys His Gly Thr Phe Val Gly Arg Ile 
        35                  40                  45              


Ala Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Pro Arg Leu Phe 
    50                  55                  60                  


Arg Val Ala Ser Lys Arg His Gly Asp Leu Leu Glu Val Asn Leu Gln 
65                  70                  75                  80  


Asn Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Gly Arg Ser Ala Glu Cys Ser Ile His Leu Glu Val Ile Val Asp Arg 
            100                 105                 110         


Pro Leu Gln Val Phe His Val Glu Val Lys Val Arg Asp Ile Asn Asp 
        115                 120                 125             


Asn Pro Pro Ile Phe Pro Glu Ser Lys Lys Arg Ile Ile Ile Ala Glu 
    130                 135                 140                 


Ser Arg Pro Pro Glu Thr Arg Phe Pro Leu Asp Gly Ala Ser Asp Ala 
145                 150                 155                 160 


Asp Ile Gly Val Asn Ser Ala Leu Thr Tyr Arg Leu Asp Pro Asn Asp 
                165                 170                 175     


Tyr Phe Thr Leu Asp Ala Gln Asn Ser Leu Glu Gln Met Ser Ser Leu 
            180                 185                 190         


Ser Leu Val Leu Arg Lys Thr Leu Asp Arg Glu Glu Ile Gln Glu His 
        195                 200                 205             


Ser Leu Leu Leu Thr Ala Ser Asp Gly Gly Lys Pro Glu Leu Thr Gly 
    210                 215                 220                 


Thr Val Gln Leu Leu Ile Thr Ile Leu Asp Val Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Glu Phe Tyr Gln Ser Val Tyr Lys Val Thr Val Leu Glu Asn Ala Phe 
                245                 250                 255     


Asn Gly Thr Leu Val Ile Lys Leu Asn Ala Thr Asp Pro Asp Asp Gly 
            260                 265                 270         


Thr Asn Gly Asp Ile Val Tyr Ser Phe Arg Arg Pro Val Trp Pro Ala 
        275                 280                 285             


Val Val Tyr Ala Phe Thr Ile Asn Pro Asn Asn Gly Glu Ile Arg Thr 
    290                 295                 300                 


Lys Gly Lys Leu Asp Phe Glu Glu Lys Lys Leu Tyr Glu Ile Ser Val 
305                 310                 315                 320 


Glu Ala Val Asp Lys Gly Asn Ile Pro Met Ala Gly His Cys Thr Leu 
                325                 330                 335     


Leu Val Glu Val Leu Asp Val Asn Asp Asn Ala Pro Glu Val Thr Ile 
            340                 345                 350         


Thr Ser Leu Ser Leu Pro Ile Arg Glu Asp Thr Gln Pro Ser Ala Ile 
        355                 360                 365             


Ile Ala Leu Ile Ser Val Ser Asp Arg Asp Ser Gly Ser Asn Gly Gln 
    370                 375                 380                 


Val Thr Cys Thr Leu Thr Pro His Val Pro Phe Lys Leu Val Ser Thr 
385                 390                 395                 400 


Tyr Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu 
                405                 410                 415     


Ser Val Ser Ala Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser 
            420                 425                 430         


Pro Ser Leu Trp Ala Thr Ala Ser Val Ser Val Gly Val Ala Asp Val 
        435                 440                 445             


Asn Asp Asn Ala Pro Ala Phe Ala Gln Pro Glu Tyr Thr Val Phe Val 
    450                 455                 460                 


Lys Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Gln 
465                 470                 475                 480 


Asp Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu 
                485                 490                 495     


Arg Arg Val Gly Glu Arg Ala Leu Ser Ser Tyr Val Ser Val His Ala 
            500                 505                 510         


Glu Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu 
        515                 520                 525             


Glu Leu Leu Gln Phe Gln Val Ser Ala Arg Asp Ser Gly Val Pro Pro 
    530                 535                 540                 


Leu Gly Ser Asn Val Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp 
545                 550                 555                 560 


Asn Ala Pro Ala Leu Leu Thr Pro Gly Ala Gly Ser Ala Gly Gly Thr 
                565                 570                 575     


Val Ser Glu Leu Met Pro Arg Ser Val Gly Ala Gly His Val Val Ala 
            580                 585                 590         


Lys Val Arg Ala Val Asp Ala Asp Ser Gly Tyr Asn Ala Trp Leu Ser 
        595                 600                 605             


Tyr Glu Leu Gln Leu Ala Ala Val Gly Ala Arg Ile Pro Phe Arg Val 
    610                 615                 620                 


Gly Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Pro Leu Asp Glu Val 
625                 630                 635                 640 


Asp Ala Pro His His Arg Leu Leu Val Leu Val Lys Asp His Gly Glu 
                645                 650                 655     


Pro Ala Leu Thr Ala Thr Ala Thr Val Leu Leu Ser Leu Val Glu Ser 
            660                 665                 670         


Gly Gln Ala Pro Gln Ala Ser Ser Arg Ala Ser Ala Gly Ala Val Gly 
        675                 680                 685             


Pro Glu Ala Ala Leu Val Asp Val Asn Val Tyr Leu Ile Ile Ala Ile 
    690                 695                 700                 


Cys Ala Val Ser Ser Leu Leu Val Leu Thr Leu Leu Leu Tyr Thr Ala 
705                 710                 715                 720 


Leu Arg Cys Ser Ala Pro Pro Thr Glu Gly Ala Cys Ala Pro Gly Lys 
                725                 730                 735     


Pro Thr Leu Val Cys Ser Ser Ala Ala Gly Ser Trp Ser Tyr Ser Gln 
            740                 745                 750         


Gln Arg Arg Pro Arg Val Cys Ser Gly Glu Gly Pro His Lys Thr Asp 
        755                 760                 765             


Leu Met Ala Phe Ser Pro Ser Leu Pro Pro Cys Leu Gly Ser Ala Glu 
    770                 775                 780                 


Gly Thr Gly Gln Arg Glu Glu Asp Ser Glu Cys Leu Lys Glu Pro Arg 
785                 790                 795                 800 


Gln Pro Asn Pro Asp Trp Arg Tyr Ser Ala Ser Leu Arg Ala Gly Met 
                805                 810                 815     


His Ser Ser Val His Leu Glu Glu Ala Gly Ile Leu Arg Ala Gly Pro 
            820                 825                 830         


Gly Gly Pro Asp Gln Gln Trp Pro Thr Val Ser Ser Ala Thr Pro Glu 
        835                 840                 845             


Pro Glu Ala Gly Glu Val Ser Pro Pro Val Gly Ala Gly Val Asn Ser 
    850                 855                 860                 


Asn Ser Trp Thr Phe Lys Tyr Gly Pro Gly Asn Pro Lys Gln Ser Gly 
865                 870                 875                 880 


Pro Glu Pro Lys Lys Gln Thr Gln Val Ser Phe Leu Leu Arg Arg Lys 
                885                 890                 895     


Gly Glu Ala Ser Gln Pro Arg Gln 
            900                 

<210>  2210
<211>  5263
<212>  DNA
<213>  Homo sapiens

<400>  2210
atgctgtctt cctggcaagg aggcccaaga ccgcggcaac tactgctctg gcttctgatc     60

ctcgcagcct gggagacggg tagtggccag ctccactact ccgtccccga ggaagcaaaa    120

cacggcacct tcgtgggccg catcgctcag gacctggggc tggagctggc ggagctggtg    180

ccgcgcctgt tccgggtggc gtccaaaaga cacggggacc ttctggaggt aaatctgcag    240

aatggcattt tgtttgtgaa ttctcggatc gaccgcgagg agctgtgtgg gcggagcgcg    300

gagtgcagca tccacctgga ggtgatcgtg gacaggcctc tgcaggtttt ccatgtggag    360

gtgaaggtga gggacattaa cgacaacccg cccatattcc ctgaaagcaa gaaacgaata    420

atcattgcag aatctagacc tccggaaact cgatttccac tagatggcgc atccgatgca    480

gatattggag taaactcggc attgacctac cgactggatc ccaacgatta tttcactttg    540

gacgcacaaa acagtcttga gcaaatgtct tcattatcac ttgtactgag gaaaacactg    600

gacagagagg aaattcagga acatagttta ttactgacag ccagtgatgg aggtaaaccc    660

gagctgactg gcacagttca gctgctcatc acgattctgg acgtgaatga caacgccccg    720

gaattttacc aatccgttta taaagtgacg gtgttagaga acgccttcaa tggaacatta    780

gtgatcaagc taaatgccac agatcctgat gatggtacaa atggagatat agtttactca    840

tttagaaggc ctgtatggcc tgcagtggta tatgcattta ccataaatcc gaacaatgga    900

gaaattagga caaaaggcaa actagatttc gaagaaaaga aattatatga aatatccgtg    960

gaggcagttg acaaaggaaa tattccaatg gcgggtcatt gtaccctttt ggtggaagta   1020

ctagatgtaa atgataacgc cccagaggtt accatcactt ctttgtcact ccccatcaga   1080

gaagacactc agcctagcgc cattattgcc ctaatcagtg tgtccgatcg tgactctggc   1140

tcaaatggac aggtcacctg caccttgacg ccgcatgtcc ccttcaagct ggtgtccacc   1200

tacaagaact actactcatt agtgctggac agcgccctgg accgcgagag cgtatcagcc   1260

tatgaactgg tggtgaccgc gcgggacggg ggctcgcctt cgctgtgggc cacggccagc   1320

gtgtcggtgg gggtggccga cgtgaacgac aacgcgccgg cgttcgcgca gcccgagtac   1380

acggtgttcg tgaaggaaaa caatccgccg ggctgccaca tcttcacggt gtctgctcag   1440

gacgcggacg cacaggagaa cgcgctggtc tcctactcgc tggtggagcg gcgggtgggc   1500

gagcgtgcgc tgtcgagcta cgtgtcggtg cacgcggaga gcggcaaggt gtacgcgctg   1560

cagccgttgg accacgagga gctggagctg ttgcagttcc aggtgagcgc gcgcgactct   1620

ggcgtgccgc ctctgggcag caacgtgacg ctgcaggtgt tcgtgctgga cgagaacgac   1680

aacgctccgg cgctgctgac gcccggggct ggcagcgcgg gaggcacagt gagcgagctg   1740

atgccgcggt cggtgggtgc aggccacgtg gtggcgaagg tgcgcgcggt ggacgccgat   1800

tcgggctaca atgcgtggct ttcgtatgaa ttgcagctgg cggcggtcgg cgcgcgcatc   1860

ccgttccgcg tggggctgta cactggcgag atcagcacga cgcgccctct ggacgaggtg   1920

gacgcgccgc accaccgcct tctggtgctg gtgaaggacc acggtgagcc cgcgctgacg   1980

gccacggcaa cggtgctgtt gtcgctggtg gagagcggcc aagcgccaca ggcttcgtcg   2040

agggcgtcgg caggcgctgt gggtccagaa gcggcgctgg tggatgtcaa tgtttacttg   2100

atcattgcca tctgcgcggt gtccagcctg ttggtgctca cgttgctgct gtatactgcg   2160

ctgcggtgct cggcaccgcc caccgagggc gcgtgcgcgc cgggcaagcc cactctagtg   2220

tgctccagcg cggcagggag ttggtcgtac tcgcagcaga ggcggccgag ggtgtgctct   2280

ggggagggcc cgcataagac ggacctcatg gccttcagtc ccagccttcc tccttgtctg   2340

ggttctgcag agggaacagg ccagagggag gaggactcag aatgcttgaa agagccacga   2400

cagcccaacc ctgactggcg ttactctgcc tccctgagag caggcatgca cagctctgtg   2460

cacctagagg aggctggcat tctacgggct ggtccaggag ggcctgatca gcagtggcca   2520

acagtatcca gtgcaacacc agaaccagag gcaggagaag tgtcccctcc agtcggtgcg   2580

ggtgtcaaca gcaacagctg gacctttaaa tacggaccag gcaaccccaa acaatccggt   2640

cccggtgagt tgcccgacaa attcattatc ccaggatctc ctgcaatcat ctccatccgg   2700

caggagccta ctaacagcca aattgacaaa agtgacttca taaccttcgg caaaaaggag   2760

gagaccaaga aaaagaagaa aaagaagaag ggtaacaaga cccaggagaa aaaagagaaa   2820

gggaacagca cgactgacaa cagtgaccag tgaggtcctc aaatggaaac aagccactta   2880

gccagttttt gtaataatgg caaatctctc ccatgtagca attccctgct cctttttcct   2940

atctacatga gccctcttag agacctcaga aatctgcaga aagttccctg tgtctgtcta   3000

gaacgcattt aacaggtttt gtcgtaaaag ctttactaag tctggtgtta actctttctc   3060

tccactctgg cttgttttca gaacctaaaa agcagaccca agtttccttt ctcctccgcc   3120

gcaaaggaga ggcttcccag ccccgccagt gagaggttgg actctctgcc ctgtgctccg   3180

gggatcctgt cttgatgaca cttgcagggc aggctgaaaa gttttgagat tgagcagctt   3240

gggagtttgt ggccactggg tatgtgtggc taccgcgggt atgcgagtgc cagatattgg   3300

ctgagacgag ccagcttaga ctaattggta caaggaaggc aagaaaacaa agacaaataa   3360

acagcggaag ttatcagtat ggaggggaag tgtaaactta aagggaccag actttctaaa   3420

tcttacaact caagaggtgg cagccaccct ctaggagaca aaactacccc cactgacaag   3480

gctttaggag accctaaagt ctgttggctg tgacgtcatt atacctaaaa tctgcatcat   3540

acctgcaagc caacagttca gtgttttaac agagaaccac cctgggaaac agaagcagat   3600

ctgatgtgtt tcctatacat gtcctgtgct cactttatta aaaattcttt tgcacacaat   3660

gtttatgaaa aggccagatc cttttccaat acttatgcaa aagcaaaaga aaaccccgac   3720

acctcacctt tcgctgtttg ttgtttcata gatttattta aaaaaagaga aagtctatag   3780

ctataaatct ttaaagagaa atatgaatac aattccccta aactctcctc aaaagagaat   3840

tcagtctaca gccatttaaa tgatcattgc tgctacagaa gtgctttaag agaattgcct   3900

gaaacatctg tattatatcg gccacctgcc aatcacagct ttactctttc aggtcactct   3960

ggggctgcct cttgcatgta ttactaaata aaatgatctc tctttctctc tctctctctc   4020

ttttctaaga aacaattatg tgcactttga tacacaacct tctctaacca actatatatc   4080

aagacccaaa aattgaagaa aaatattgtt ttctcataca gtgagcagat ttttcaatct   4140

actaattctg tgacttgtct tggtgtgcta gcctacacct tctctttggt ttagttttcc   4200

ttttctataa cactctgaat tgctaatctt actaacacct atgatgttac ctgaaatcaa   4260

tctcccatat gtatgctgta tgctatgcta agactcctga aatatactta ctctgtgctt   4320

gtgtatgtga atgttaatgc aactattacc tagagtgaac tttaagcttt attgttgaat   4380

gtaattccat tatatttcct tttgtacacc tgtgaaaaag tggagtagtg tttttttaac   4440

cattgttaat cagcttttgt gtatgaaaga cacagtaaaa tttctttctt aaatcaagat   4500

actggtgatt caaggaattt tatttatggt ccagccaaga gccatctcgt gccaagactt   4560

ctgctggcaa gggaatggat aaagctgttt tgttctagta acaattttgg aatgaatact   4620

gacaatattc catgagggtg tgcaagcaca aattttacca atctgacctc tttgaagttg   4680

cagaatgctt tgaaattcta atggtatctg aaatatcagc tcatagaaag taacaaaatt   4740

tgctgtcacc ttaaataaga cattttaatt ttgttataat gtacaattta gaagtttgat   4800

taattatatt atctatttag gcattaatat aaaagaggta ggagtctgtt atttaaaaaa   4860

agcattaaat ttaaaaaaaa actgtcttgt ctacttttag cttcattctc ccatattttg   4920

aagggtgtgt aacttcagct ctgcaggatt gcatggggta aaacttgtta ccaacacatg   4980

tgaaccattg ctacattgta ggttgtgatc attttgcccc actgaagccc atgtatctga   5040

ccttacgtgc cttttgaact aggagaatcg ggctaattta ttaatgatga taattataat   5100

gtatctgtac agcacttttt acatttgcga agtgctttcc aatccatgtt agttactagt   5160

tattacagct gtaaggataa aacacgtcat gtggattcat tttgaattgg tgctattggt   5220

atttcctctg ttattgctaa taaatgaaaa tggtggtatg aaa                     5263


<210>  2211
<211>  950
<212>  PRT
<213>  Homo sapiens

<400>  2211


Met Leu Ser Ser Trp Gln Gly Gly Pro Arg Pro Arg Gln Leu Leu Leu 
1               5                   10                  15      


Trp Leu Leu Ile Leu Ala Ala Trp Glu Thr Gly Ser Gly Gln Leu His 
            20                  25                  30          


Tyr Ser Val Pro Glu Glu Ala Lys His Gly Thr Phe Val Gly Arg Ile 
        35                  40                  45              


Ala Gln Asp Leu Gly Leu Glu Leu Ala Glu Leu Val Pro Arg Leu Phe 
    50                  55                  60                  


Arg Val Ala Ser Lys Arg His Gly Asp Leu Leu Glu Val Asn Leu Gln 
65                  70                  75                  80  


Asn Gly Ile Leu Phe Val Asn Ser Arg Ile Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Gly Arg Ser Ala Glu Cys Ser Ile His Leu Glu Val Ile Val Asp Arg 
            100                 105                 110         


Pro Leu Gln Val Phe His Val Glu Val Lys Val Arg Asp Ile Asn Asp 
        115                 120                 125             


Asn Pro Pro Ile Phe Pro Glu Ser Lys Lys Arg Ile Ile Ile Ala Glu 
    130                 135                 140                 


Ser Arg Pro Pro Glu Thr Arg Phe Pro Leu Asp Gly Ala Ser Asp Ala 
145                 150                 155                 160 


Asp Ile Gly Val Asn Ser Ala Leu Thr Tyr Arg Leu Asp Pro Asn Asp 
                165                 170                 175     


Tyr Phe Thr Leu Asp Ala Gln Asn Ser Leu Glu Gln Met Ser Ser Leu 
            180                 185                 190         


Ser Leu Val Leu Arg Lys Thr Leu Asp Arg Glu Glu Ile Gln Glu His 
        195                 200                 205             


Ser Leu Leu Leu Thr Ala Ser Asp Gly Gly Lys Pro Glu Leu Thr Gly 
    210                 215                 220                 


Thr Val Gln Leu Leu Ile Thr Ile Leu Asp Val Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Glu Phe Tyr Gln Ser Val Tyr Lys Val Thr Val Leu Glu Asn Ala Phe 
                245                 250                 255     


Asn Gly Thr Leu Val Ile Lys Leu Asn Ala Thr Asp Pro Asp Asp Gly 
            260                 265                 270         


Thr Asn Gly Asp Ile Val Tyr Ser Phe Arg Arg Pro Val Trp Pro Ala 
        275                 280                 285             


Val Val Tyr Ala Phe Thr Ile Asn Pro Asn Asn Gly Glu Ile Arg Thr 
    290                 295                 300                 


Lys Gly Lys Leu Asp Phe Glu Glu Lys Lys Leu Tyr Glu Ile Ser Val 
305                 310                 315                 320 


Glu Ala Val Asp Lys Gly Asn Ile Pro Met Ala Gly His Cys Thr Leu 
                325                 330                 335     


Leu Val Glu Val Leu Asp Val Asn Asp Asn Ala Pro Glu Val Thr Ile 
            340                 345                 350         


Thr Ser Leu Ser Leu Pro Ile Arg Glu Asp Thr Gln Pro Ser Ala Ile 
        355                 360                 365             


Ile Ala Leu Ile Ser Val Ser Asp Arg Asp Ser Gly Ser Asn Gly Gln 
    370                 375                 380                 


Val Thr Cys Thr Leu Thr Pro His Val Pro Phe Lys Leu Val Ser Thr 
385                 390                 395                 400 


Tyr Lys Asn Tyr Tyr Ser Leu Val Leu Asp Ser Ala Leu Asp Arg Glu 
                405                 410                 415     


Ser Val Ser Ala Tyr Glu Leu Val Val Thr Ala Arg Asp Gly Gly Ser 
            420                 425                 430         


Pro Ser Leu Trp Ala Thr Ala Ser Val Ser Val Gly Val Ala Asp Val 
        435                 440                 445             


Asn Asp Asn Ala Pro Ala Phe Ala Gln Pro Glu Tyr Thr Val Phe Val 
    450                 455                 460                 


Lys Glu Asn Asn Pro Pro Gly Cys His Ile Phe Thr Val Ser Ala Gln 
465                 470                 475                 480 


Asp Ala Asp Ala Gln Glu Asn Ala Leu Val Ser Tyr Ser Leu Val Glu 
                485                 490                 495     


Arg Arg Val Gly Glu Arg Ala Leu Ser Ser Tyr Val Ser Val His Ala 
            500                 505                 510         


Glu Ser Gly Lys Val Tyr Ala Leu Gln Pro Leu Asp His Glu Glu Leu 
        515                 520                 525             


Glu Leu Leu Gln Phe Gln Val Ser Ala Arg Asp Ser Gly Val Pro Pro 
    530                 535                 540                 


Leu Gly Ser Asn Val Thr Leu Gln Val Phe Val Leu Asp Glu Asn Asp 
545                 550                 555                 560 


Asn Ala Pro Ala Leu Leu Thr Pro Gly Ala Gly Ser Ala Gly Gly Thr 
                565                 570                 575     


Val Ser Glu Leu Met Pro Arg Ser Val Gly Ala Gly His Val Val Ala 
            580                 585                 590         


Lys Val Arg Ala Val Asp Ala Asp Ser Gly Tyr Asn Ala Trp Leu Ser 
        595                 600                 605             


Tyr Glu Leu Gln Leu Ala Ala Val Gly Ala Arg Ile Pro Phe Arg Val 
    610                 615                 620                 


Gly Leu Tyr Thr Gly Glu Ile Ser Thr Thr Arg Pro Leu Asp Glu Val 
625                 630                 635                 640 


Asp Ala Pro His His Arg Leu Leu Val Leu Val Lys Asp His Gly Glu 
                645                 650                 655     


Pro Ala Leu Thr Ala Thr Ala Thr Val Leu Leu Ser Leu Val Glu Ser 
            660                 665                 670         


Gly Gln Ala Pro Gln Ala Ser Ser Arg Ala Ser Ala Gly Ala Val Gly 
        675                 680                 685             


Pro Glu Ala Ala Leu Val Asp Val Asn Val Tyr Leu Ile Ile Ala Ile 
    690                 695                 700                 


Cys Ala Val Ser Ser Leu Leu Val Leu Thr Leu Leu Leu Tyr Thr Ala 
705                 710                 715                 720 


Leu Arg Cys Ser Ala Pro Pro Thr Glu Gly Ala Cys Ala Pro Gly Lys 
                725                 730                 735     


Pro Thr Leu Val Cys Ser Ser Ala Ala Gly Ser Trp Ser Tyr Ser Gln 
            740                 745                 750         


Gln Arg Arg Pro Arg Val Cys Ser Gly Glu Gly Pro His Lys Thr Asp 
        755                 760                 765             


Leu Met Ala Phe Ser Pro Ser Leu Pro Pro Cys Leu Gly Ser Ala Glu 
    770                 775                 780                 


Gly Thr Gly Gln Arg Glu Glu Asp Ser Glu Cys Leu Lys Glu Pro Arg 
785                 790                 795                 800 


Gln Pro Asn Pro Asp Trp Arg Tyr Ser Ala Ser Leu Arg Ala Gly Met 
                805                 810                 815     


His Ser Ser Val His Leu Glu Glu Ala Gly Ile Leu Arg Ala Gly Pro 
            820                 825                 830         


Gly Gly Pro Asp Gln Gln Trp Pro Thr Val Ser Ser Ala Thr Pro Glu 
        835                 840                 845             


Pro Glu Ala Gly Glu Val Ser Pro Pro Val Gly Ala Gly Val Asn Ser 
    850                 855                 860                 


Asn Ser Trp Thr Phe Lys Tyr Gly Pro Gly Asn Pro Lys Gln Ser Gly 
865                 870                 875                 880 


Pro Gly Glu Leu Pro Asp Lys Phe Ile Ile Pro Gly Ser Pro Ala Ile 
                885                 890                 895     


Ile Ser Ile Arg Gln Glu Pro Thr Asn Ser Gln Ile Asp Lys Ser Asp 
            900                 905                 910         


Phe Ile Thr Phe Gly Lys Lys Glu Glu Thr Lys Lys Lys Lys Lys Lys 
        915                 920                 925             


Lys Lys Gly Asn Lys Thr Gln Glu Lys Lys Glu Lys Gly Asn Ser Thr 
    930                 935                 940                 


Thr Asp Asn Ser Asp Gln 
945                 950 

<210>  2212
<211>  5237
<212>  DNA
<213>  Homo sapiens

<400>  2212
acttctttcg gggggctcct gtttccttaa gcctagaagg tgtggtcgct cacgttcacc     60

gtcccgcctc tcgccgcctc cgctcggcag ctccacgctg agtcccgccc tctccgccgg    120

agaggtgcgc cggggtcaga gcgccgggac ccgacgcgcg gctcccaaag ggcggcagga    180

agagcccagc tgggctcagc cacagttatc agcaatctgc gggcagagga tgtggaggtt    240

aagatctggg cagcctcagg gcgttgtcct agaaaacacc gtttaaggag agaagtgtta    300

gtgtctcggg gcgtctccca ggctccgccc tgcgcccgca gccagcgtgg tggtcgagac    360

cccagcccgc tgctactgga gacagcacct ctcgcgcccg ggcgggcggc ctcgtctctg    420

cacccctagg cggcgctgcg ctcctcaaca cccggccggc tccgctttcc cagacggctg    480

cccagcctcc agcctagcaa gcccggctcc cagctggcca gccccggcaa tgccggcgtt    540

cgggaggcgc aacgtcggcg gtcgctgagt atccagcccg cagcagtgac ggccggcagg    600

agcgtgctct tccccgcggc tcgtgctctc caggagtccg gagcatggtc ctgggtcacc    660

gttggtgtag cgtgttggtg gaacgtggac gcctagaggg aggatggtgg gctgtggggt    720

ggcagtttta tgtttgtggg tttcctgcgg cgctgcagcg ggacagctcg agtactcagt    780

gccggaggag acggagcggg gcgtagccgt aggcaatctc tccgcggact tgaggctgcc    840

agcggccgct atgtcctcgc ggaactttcg cttcctttcc agccaccgcg agctctactt    900

cggggtggat ctacccagcg gcaatttggt ggtcagagag ccggcggacc gcgaacagct    960

gtgcagggcc aaagctgcct gcgtcttgac ctacgacctg gtgctcgagg acccgctgga   1020

gctgcacaag attcggattc acgtcctgga caccaatgac aactcacctc tctttcctgc   1080

cggcgacgtg cagctgcaca tccccgagtt cctgacgccc ggagcccgct ttactctccc   1140

gaatgcccaa gatgacgacg agggaagcaa tgggatacta agctacagcc taagccccag   1200

tcagcacttt cgcctggaca tgggatcgcg ggttgacggc agcgaatacc cggagttggt   1260

gttggagaaa gcactggatc gcgaacagcg cgccacccac ctgctggtgc ttacagctcg   1320

ggacggcggg ctacctgccc gctcaggaga cgcacaagtc accatcattg tggtggacac   1380

aaatgacaac gcgcctgtat ttgagcgctc cgtataccgc accaaggttc cagagactgc   1440

acccaatggg actgtgttat tccgagttca agccttggat ccagatgaag ggtccaatgg   1500

ggaagtccag tactccctaa gcaacagcac gcaagcagag ctgcgacacc gctttcacgt   1560

gcaccctaaa agtggggagg tgcaagtagc tgcttcacta ggtccgcctg aaacgctctt   1620

ggaggcatac attgaggcga gggacgaagg tgtctttggt ttagctagca ccgctaaact   1680

gctggtggag gtgactgacg tgaacgatca tgcccccgaa ctggacttcc tgactctttc   1740

gaacccagta cctgaggacg ctgcccctgg cacagtgatt gctctcttta gtgtaaagga   1800

tgaagacctc gattctaatg gtagggtcat ttgtggcatg tctagtgcag gcccttttca   1860

gctgacggct tcctttgaca actactacag cctgctgatt gatgggcccc tggaccggga   1920

gcagatcagt gaataccaag tcctgatcac ggcctcagat agtggctcac ccccacttag   1980

cacccgaagg acaatcactg tgtcagttgc tgatgtgaat gacaatacac caaactttcc   2040

tcaaccccag caggaacttt tcgttgctga aaacaatggc cctggggcct ctctaggccg   2100

agtgtttgcc caggaccccg acctggggaa gaatggcctt gtctcttatg agctgttgga   2160

tgttatctct gaagggccat cagcctctag cttgctggca gtggaatcat ccagtggggc   2220

catcactgcc aaaacttcct ttgactttga gcagctcagg gggtttcatt tccaagtaga   2280

aggccgggat ggtggcattc ctcccagaag tgcaacagtg actataaact tgtttgtggt   2340

agataggaat gacaattatc cggttatctt gtttcccttg cccagaaatg gttctgtccc   2400

agtggaaatt gtgccccgct ctgccaggac tggacacttg gtcacaaaag tggtagcaga   2460

ggatgctgac agtggttcta atgcctggct ttcctaccac atctcccggg cgtctgactc   2520

tagtctcttt agaatttcag ccaatatagg tgagctccgt actgctcgct tagttcttcc   2580

cactgatgca gttaagcaga gggtggtggt agtggttcgg gaccatggag acccaccact   2640

ttcctcctct gtcactctgg gtgtgctgtt gagcaactct gtccctcagt tacttccaga   2700

ctttgaagat gtctgggaac caggagggca gctttctgcc cagaacttgt atttagtaat   2760

tgccttggct tgtatttcct ttttatttct ggggtgctta cttttcttcg tgtgtaccaa   2820

gttgcaccag agcccaggct gttgcgctca gagctgctgt cgctctacag aggatctgag   2880

gtatggaagt aagatggttt caaatccttg catgacatca gccaccatag atgtcactac   2940

agttgagaga ctttctcaga cttatctcta tcgggcctct ctgggacttg gttctgataa   3000

taacagtttg ctgttgcgtg gggagtacaa tgctgccgac ctgcgaaatc ttgccactgg   3060

ggtaggactg aatttgccaa tatcctgtat tcagattcgg aataggaaag gggatcacgc   3120

taatgtcaat gccatgccac gacagcccaa ccctgactgg cgttactctg cctccctgag   3180

agcaggcatg cacagctctg tgcacctaga ggaggctggc attctacggg ctggtccagg   3240

agggcctgat cagcagtggc caacagtatc cagtgcaaca ccagaaccag aggcaggaga   3300

agtgtcccct ccagtcggtg cgggtgtcaa cagcaacagc tggaccttta aatacggacc   3360

aggcaacccc aaacaatccg gtcccggtga gttgcccgac aaattcatta tcccaggatc   3420

tcctgcaatc atctccatcc ggcaggagcc tactaacagc caaattgaca aaagtgactt   3480

cataaccttc ggcaaaaagg aggagaccaa gaaaaagaag aaaaagaaga agggtaacaa   3540

gacccaggag aaaaaagaga aagggaacag cacgactgac aacagtgacc agtgaggtcc   3600

tcaaatggaa acaagccact tagccagttt ttgtaataat ggcaaatctc tcccatgtag   3660

caattccctg ctcctttttc ctatctacat gagccctctt agagacctca gaaatctgca   3720

gaaagttccc tgtgtctgtc tagaacgcat ttaacaggtt ttgtcgtaaa agctttacta   3780

agtctggtgt taactctttc tctccactct ggcttgtttt cagaacctaa aaagcagacc   3840

caagtttcct ttctcctccg ccgcaaagga gaggcttccc agccccgcca gtgagaggtt   3900

ggactctctg ccctgtgctc cggggatcct gtcttgatga cacttgcagg gcaggctgaa   3960

aagttttgag attgagcagc ttgggagttt gtggccactg ggtatgtgtg gctaccgcgg   4020

gtatgcgagt gccagatatt ggctgagacg agccagctta gactaattgg tacaaggaag   4080

gcaagaaaac aaagacaaat aaacagcgga agttatcagt atggagggga agtgtaaact   4140

taaagggacc agactttcta aatcttacaa ctcaagaggt ggcagccacc ctctaggaga   4200

caaaactacc cccactgaca aggctttagg agaccctaaa gtctgttggc tgtgacgtca   4260

ttatacctaa aatctgcatc atacctgcaa gccaacagtt cagtgtttta acagagaacc   4320

accctgggaa acagaagcag atctgatgtg tttcctatac atgtcctgtg ctcactttat   4380

taaaaattct tttgcacaca atgtttatga aaaggccaga tccttttcca atacttatgc   4440

aaaagcaaaa gaaaaccccg acacctcacc tttcgctgtt tgttgtttca tagatttatt   4500

taaaaaaaga gaaagtctat agctataaat ctttaaagag aaatatgaat acaattcccc   4560

taaactctcc tcaaaagaga attcagtcta cagccattta aatgatcatt gctgctacag   4620

aagtgcttta agagaattgc ctgaaacatc tgtattatat cggccacctg ccaatcacag   4680

ctttactctt tcaggtcact ctggggctgc ctcttgcatg tattactaaa taaaatgatc   4740

tctctttctc tctctctctc tcttttctaa gaaacaatta tgtgcacttt gatacacaac   4800

cttctctaac caactatata tcaagaccca aaaattgaag aaaaatattg ttttctcata   4860

cagtgagcag atttttcaat ctactaattc tgtgacttgt cttggtgtgc tagcctacac   4920

cttctctttg gtttagtttt ccttttctat aacactctga attgctaatc ttactaacac   4980

ctatgatgtt acctgaaatc aatctcccat atgtatgctg tatgctatgc taagactcct   5040

gaaatatact tactctgtgc ttgtgtatgt gaatgttaat gcaactatta cctagagtga   5100

actttaagct ttattgttga atgtaattcc attatatttc cttttgtaca cctgtgaaaa   5160

agtggagtag tgttttttta accattgtta atcagctttt gtgtatgaaa gacacagtaa   5220

aatttctttc ttaaatc                                                  5237


<210>  2213
<211>  963
<212>  PRT
<213>  Homo sapiens

<400>  2213


Met Val Gly Cys Gly Val Ala Val Leu Cys Leu Trp Val Ser Cys Gly 
1               5                   10                  15      


Ala Ala Ala Gly Gln Leu Glu Tyr Ser Val Pro Glu Glu Thr Glu Arg 
            20                  25                  30          


Gly Val Ala Val Gly Asn Leu Ser Ala Asp Leu Arg Leu Pro Ala Ala 
        35                  40                  45              


Ala Met Ser Ser Arg Asn Phe Arg Phe Leu Ser Ser His Arg Glu Leu 
    50                  55                  60                  


Tyr Phe Gly Val Asp Leu Pro Ser Gly Asn Leu Val Val Arg Glu Pro 
65                  70                  75                  80  


Ala Asp Arg Glu Gln Leu Cys Arg Ala Lys Ala Ala Cys Val Leu Thr 
                85                  90                  95      


Tyr Asp Leu Val Leu Glu Asp Pro Leu Glu Leu His Lys Ile Arg Ile 
            100                 105                 110         


His Val Leu Asp Thr Asn Asp Asn Ser Pro Leu Phe Pro Ala Gly Asp 
        115                 120                 125             


Val Gln Leu His Ile Pro Glu Phe Leu Thr Pro Gly Ala Arg Phe Thr 
    130                 135                 140                 


Leu Pro Asn Ala Gln Asp Asp Asp Glu Gly Ser Asn Gly Ile Leu Ser 
145                 150                 155                 160 


Tyr Ser Leu Ser Pro Ser Gln His Phe Arg Leu Asp Met Gly Ser Arg 
                165                 170                 175     


Val Asp Gly Ser Glu Tyr Pro Glu Leu Val Leu Glu Lys Ala Leu Asp 
            180                 185                 190         


Arg Glu Gln Arg Ala Thr His Leu Leu Val Leu Thr Ala Arg Asp Gly 
        195                 200                 205             


Gly Leu Pro Ala Arg Ser Gly Asp Ala Gln Val Thr Ile Ile Val Val 
    210                 215                 220                 


Asp Thr Asn Asp Asn Ala Pro Val Phe Glu Arg Ser Val Tyr Arg Thr 
225                 230                 235                 240 


Lys Val Pro Glu Thr Ala Pro Asn Gly Thr Val Leu Phe Arg Val Gln 
                245                 250                 255     


Ala Leu Asp Pro Asp Glu Gly Ser Asn Gly Glu Val Gln Tyr Ser Leu 
            260                 265                 270         


Ser Asn Ser Thr Gln Ala Glu Leu Arg His Arg Phe His Val His Pro 
        275                 280                 285             


Lys Ser Gly Glu Val Gln Val Ala Ala Ser Leu Gly Pro Pro Glu Thr 
    290                 295                 300                 


Leu Leu Glu Ala Tyr Ile Glu Ala Arg Asp Glu Gly Val Phe Gly Leu 
305                 310                 315                 320 


Ala Ser Thr Ala Lys Leu Leu Val Glu Val Thr Asp Val Asn Asp His 
                325                 330                 335     


Ala Pro Glu Leu Asp Phe Leu Thr Leu Ser Asn Pro Val Pro Glu Asp 
            340                 345                 350         


Ala Ala Pro Gly Thr Val Ile Ala Leu Phe Ser Val Lys Asp Glu Asp 
        355                 360                 365             


Leu Asp Ser Asn Gly Arg Val Ile Cys Gly Met Ser Ser Ala Gly Pro 
    370                 375                 380                 


Phe Gln Leu Thr Ala Ser Phe Asp Asn Tyr Tyr Ser Leu Leu Ile Asp 
385                 390                 395                 400 


Gly Pro Leu Asp Arg Glu Gln Ile Ser Glu Tyr Gln Val Leu Ile Thr 
                405                 410                 415     


Ala Ser Asp Ser Gly Ser Pro Pro Leu Ser Thr Arg Arg Thr Ile Thr 
            420                 425                 430         


Val Ser Val Ala Asp Val Asn Asp Asn Thr Pro Asn Phe Pro Gln Pro 
        435                 440                 445             


Gln Gln Glu Leu Phe Val Ala Glu Asn Asn Gly Pro Gly Ala Ser Leu 
    450                 455                 460                 


Gly Arg Val Phe Ala Gln Asp Pro Asp Leu Gly Lys Asn Gly Leu Val 
465                 470                 475                 480 


Ser Tyr Glu Leu Leu Asp Val Ile Ser Glu Gly Pro Ser Ala Ser Ser 
                485                 490                 495     


Leu Leu Ala Val Glu Ser Ser Ser Gly Ala Ile Thr Ala Lys Thr Ser 
            500                 505                 510         


Phe Asp Phe Glu Gln Leu Arg Gly Phe His Phe Gln Val Glu Gly Arg 
        515                 520                 525             


Asp Gly Gly Ile Pro Pro Arg Ser Ala Thr Val Thr Ile Asn Leu Phe 
    530                 535                 540                 


Val Val Asp Arg Asn Asp Asn Tyr Pro Val Ile Leu Phe Pro Leu Pro 
545                 550                 555                 560 


Arg Asn Gly Ser Val Pro Val Glu Ile Val Pro Arg Ser Ala Arg Thr 
                565                 570                 575     


Gly His Leu Val Thr Lys Val Val Ala Glu Asp Ala Asp Ser Gly Ser 
            580                 585                 590         


Asn Ala Trp Leu Ser Tyr His Ile Ser Arg Ala Ser Asp Ser Ser Leu 
        595                 600                 605             


Phe Arg Ile Ser Ala Asn Ile Gly Glu Leu Arg Thr Ala Arg Leu Val 
    610                 615                 620                 


Leu Pro Thr Asp Ala Val Lys Gln Arg Val Val Val Val Val Arg Asp 
625                 630                 635                 640 


His Gly Asp Pro Pro Leu Ser Ser Ser Val Thr Leu Gly Val Leu Leu 
                645                 650                 655     


Ser Asn Ser Val Pro Gln Leu Leu Pro Asp Phe Glu Asp Val Trp Glu 
            660                 665                 670         


Pro Gly Gly Gln Leu Ser Ala Gln Asn Leu Tyr Leu Val Ile Ala Leu 
        675                 680                 685             


Ala Cys Ile Ser Phe Leu Phe Leu Gly Cys Leu Leu Phe Phe Val Cys 
    690                 695                 700                 


Thr Lys Leu His Gln Ser Pro Gly Cys Cys Ala Gln Ser Cys Cys Arg 
705                 710                 715                 720 


Ser Thr Glu Asp Leu Arg Tyr Gly Ser Lys Met Val Ser Asn Pro Cys 
                725                 730                 735     


Met Thr Ser Ala Thr Ile Asp Val Thr Thr Val Glu Arg Leu Ser Gln 
            740                 745                 750         


Thr Tyr Leu Tyr Arg Ala Ser Leu Gly Leu Gly Ser Asp Asn Asn Ser 
        755                 760                 765             


Leu Leu Leu Arg Gly Glu Tyr Asn Ala Ala Asp Leu Arg Asn Leu Ala 
    770                 775                 780                 


Thr Gly Val Gly Leu Asn Leu Pro Ile Ser Cys Ile Gln Ile Arg Asn 
785                 790                 795                 800 


Arg Lys Gly Asp His Ala Asn Val Asn Ala Met Pro Arg Gln Pro Asn 
                805                 810                 815     


Pro Asp Trp Arg Tyr Ser Ala Ser Leu Arg Ala Gly Met His Ser Ser 
            820                 825                 830         


Val His Leu Glu Glu Ala Gly Ile Leu Arg Ala Gly Pro Gly Gly Pro 
        835                 840                 845             


Asp Gln Gln Trp Pro Thr Val Ser Ser Ala Thr Pro Glu Pro Glu Ala 
    850                 855                 860                 


Gly Glu Val Ser Pro Pro Val Gly Ala Gly Val Asn Ser Asn Ser Trp 
865                 870                 875                 880 


Thr Phe Lys Tyr Gly Pro Gly Asn Pro Lys Gln Ser Gly Pro Gly Glu 
                885                 890                 895     


Leu Pro Asp Lys Phe Ile Ile Pro Gly Ser Pro Ala Ile Ile Ser Ile 
            900                 905                 910         


Arg Gln Glu Pro Thr Asn Ser Gln Ile Asp Lys Ser Asp Phe Ile Thr 
        915                 920                 925             


Phe Gly Lys Lys Glu Glu Thr Lys Lys Lys Lys Lys Lys Lys Lys Gly 
    930                 935                 940                 


Asn Lys Thr Gln Glu Lys Lys Glu Lys Gly Asn Ser Thr Thr Asp Asn 
945                 950                 955                 960 


Ser Asp Gln 
            

<210>  2214
<211>  6005
<212>  DNA
<213>  Homo sapiens

<400>  2214
acttctttcg gggggctcct gtttccttaa gcctagaagg tgtggtcgct cacgttcacc     60

gtcccgcctc tcgccgcctc cgctcggcag ctccacgctg agtcccgccc tctccgccgg    120

agaggtgcgc cggggtcaga gcgccgggac ccgacgcgcg gctcccaaag ggcggcagga    180

agagcccagc tgggctcagc cacagttatc agcaatctgc gggcagagga tgtggaggtt    240

aagatctggg cagcctcagg gcgttgtcct agaaaacacc gtttaaggag agaagtgtta    300

gtgtctcggg gcgtctccca ggctccgccc tgcgcccgca gccagcgtgg tggtcgagac    360

cccagcccgc tgctactgga gacagcacct ctcgcgcccg ggcgggcggc ctcgtctctg    420

cacccctagg cggcgctgcg ctcctcaaca cccggccggc tccgctttcc cagacggctg    480

cccagcctcc agcctagcaa gcccggctcc cagctggcca gccccggcaa tgccggcgtt    540

cgggaggcgc aacgtcggcg gtcgctgagt atccagcccg cagcagtgac ggccggcagg    600

agcgtgctct tccccgcggc tcgtgctctc caggagtccg gagcatggtc ctgggtcacc    660

gttggtgtag cgtgttggtg gaacgtggac gcctagaggg aggatggtgg gctgtggggt    720

ggcagtttta tgtttgtggg tttcctgcgg cgctgcagcg ggacagctcg agtactcagt    780

gccggaggag acggagcggg gcgtagccgt aggcaatctc tccgcggact tgaggctgcc    840

agcggccgct atgtcctcgc ggaactttcg cttcctttcc agccaccgcg agctctactt    900

cggggtggat ctacccagcg gcaatttggt ggtcagagag ccggcggacc gcgaacagct    960

gtgcagggcc aaagctgcct gcgtcttgac ctacgacctg gtgctcgagg acccgctgga   1020

gctgcacaag attcggattc acgtcctgga caccaatgac aactcacctc tctttcctgc   1080

cggcgacgtg cagctgcaca tccccgagtt cctgacgccc ggagcccgct ttactctccc   1140

gaatgcccaa gatgacgacg agggaagcaa tgggatacta agctacagcc taagccccag   1200

tcagcacttt cgcctggaca tgggatcgcg ggttgacggc agcgaatacc cggagttggt   1260

gttggagaaa gcactggatc gcgaacagcg cgccacccac ctgctggtgc ttacagctcg   1320

ggacggcggg ctacctgccc gctcaggaga cgcacaagtc accatcattg tggtggacac   1380

aaatgacaac gcgcctgtat ttgagcgctc cgtataccgc accaaggttc cagagactgc   1440

acccaatggg actgtgttat tccgagttca agccttggat ccagatgaag ggtccaatgg   1500

ggaagtccag tactccctaa gcaacagcac gcaagcagag ctgcgacacc gctttcacgt   1560

gcaccctaaa agtggggagg tgcaagtagc tgcttcacta ggtccgcctg aaacgctctt   1620

ggaggcatac attgaggcga gggacgaagg tgtctttggt ttagctagca ccgctaaact   1680

gctggtggag gtgactgacg tgaacgatca tgcccccgaa ctggacttcc tgactctttc   1740

gaacccagta cctgaggacg ctgcccctgg cacagtgatt gctctcttta gtgtaaagga   1800

tgaagacctc gattctaatg gtagggtcat ttgtggcatg tctagtgcag gcccttttca   1860

gctgacggct tcctttgaca actactacag cctgctgatt gatgggcccc tggaccggga   1920

gcagatcagt gaataccaag tcctgatcac ggcctcagat agtggctcac ccccacttag   1980

cacccgaagg acaatcactg tgtcagttgc tgatgtgaat gacaatacac caaactttcc   2040

tcaaccccag caggaacttt tcgttgctga aaacaatggc cctggggcct ctctaggccg   2100

agtgtttgcc caggaccccg acctggggaa gaatggcctt gtctcttatg agctgttgga   2160

tgttatctct gaagggccat cagcctctag cttgctggca gtggaatcat ccagtggggc   2220

catcactgcc aaaacttcct ttgactttga gcagctcagg gggtttcatt tccaagtaga   2280

aggccgggat ggtggcattc ctcccagaag tgcaacagtg actataaact tgtttgtggt   2340

agataggaat gacaattatc cggttatctt gtttcccttg cccagaaatg gttctgtccc   2400

agtggaaatt gtgccccgct ctgccaggac tggacacttg gtcacaaaag tggtagcaga   2460

ggatgctgac agtggttcta atgcctggct ttcctaccac atctcccggg cgtctgactc   2520

tagtctcttt agaatttcag ccaatatagg tgagctccgt actgctcgct tagttcttcc   2580

cactgatgca gttaagcaga gggtggtggt agtggttcgg gaccatggag acccaccact   2640

ttcctcctct gtcactctgg gtgtgctgtt gagcaactct gtccctcagt tacttccaga   2700

ctttgaagat gtctgggaac caggagggca gctttctgcc cagaacttgt atttagtaat   2760

tgccttggct tgtatttcct ttttatttct ggggtgctta cttttcttcg tgtgtaccaa   2820

gttgcaccag agcccaggct gttgcgctca gagctgctgt cgctctacag aggatctgag   2880

gtatggaagt aagatggttt caaatccttg catgacatca gccaccatag atgtcactac   2940

agttgagaga ctttctcaga cttatctcta tcgggcctct ctgggacttg gttctgataa   3000

taacagtttg ctgttgcgtg gggagtacaa tgctgccgac ctgcgaaatc ttgccactgg   3060

ggtaggactg aatttgccaa tatcctgtat tcagattcgg aataggaaag gggatcacgc   3120

taatgtcaat gccatgccac gacagcccaa ccctgactgg cgttactctg cctccctgag   3180

agcaggcatg cacagctctg tgcacctaga ggaggctggc attctacggg ctggtccagg   3240

agggcctgat cagcagtggc caacagtatc cagtgcaaca ccagaaccag aggcaggaga   3300

agtgtcccct ccagtcggtg cgggtgtcaa cagcaacagc tggaccttta aatacggacc   3360

aggcaacccc aaacaatccg gtcccggtga gttgcccgac aaattcatta tcccaggatc   3420

tcctgcaatc atctccatcc ggcaggagcc tactaacagc caaattgaca aaagtgactt   3480

cataaccttc ggcaaaaagg aggagaccaa gaaaaagaag aaaaagaaga agggtaacaa   3540

gacccaggag aaaaaagaga aagggaacag cacgactgac aacagtgacc agtgaggtcc   3600

tcaaatggaa acaagccact tagccagttt ttgtaataat ggcaaatctc tcccatgtag   3660

caattccctg ctcctttttc ctatctacat gagccctctt agagacctca gaaatctgca   3720

gaaagttccc tgtgtctgtc tagaacgcat ttaacaggtt ttgtcgtaaa agctttacta   3780

agtctggtgt taactctttc tctccactct ggcttgtttt cagaacctaa aaagcagacc   3840

caagtttcct ttctcctccg ccgcaaagga gaggcttccc agccccgcca gtgagaggtt   3900

ggactctctg ccctgtgctc cggggatcct gtcttgatga cacttgcagg gcaggctgaa   3960

aagttttgag attgagcagc ttgggagttt gtggccactg ggtatgtgtg gctaccgcgg   4020

gtatgcgagt gccagatatt ggctgagacg agccagctta gactaattgg tacaaggaag   4080

gcaagaaaac aaagacaaat aaacagcgga agttatcagt atggagggga agtgtaaact   4140

taaagggacc agactttcta aatcttacaa ctcaagaggt ggcagccacc ctctaggaga   4200

caaaactacc cccactgaca aggctttagg agaccctaaa gtctgttggc tgtgacgtca   4260

ttatacctaa aatctgcatc atacctgcaa gccaacagtt cagtgtttta acagagaacc   4320

accctgggaa acagaagcag atctgatgtg tttcctatac atgtcctgtg ctcactttat   4380

taaaaattct tttgcacaca atgtttatga aaaggccaga tccttttcca atacttatgc   4440

aaaagcaaaa gaaaaccccg acacctcacc tttcgctgtt tgttgtttca tagatttatt   4500

taaaaaaaga gaaagtctat agctataaat ctttaaagag aaatatgaat acaattcccc   4560

taaactctcc tcaaaagaga attcagtcta cagccattta aatgatcatt gctgctacag   4620

aagtgcttta agagaattgc ctgaaacatc tgtattatat cggccacctg ccaatcacag   4680

ctttactctt tcaggtcact ctggggctgc ctcttgcatg tattactaaa taaaatgatc   4740

tctctttctc tctctctctc tcttttctaa gaaacaatta tgtgcacttt gatacacaac   4800

cttctctaac caactatata tcaagaccca aaaattgaag aaaaatattg ttttctcata   4860

cagtgagcag atttttcaat ctactaattc tgtgacttgt cttggtgtgc tagcctacac   4920

cttctctttg gtttagtttt ccttttctat aacactctga attgctaatc ttactaacac   4980

ctatgatgtt acctgaaatc aatctcccat atgtatgctg tatgctatgc taagactcct   5040

gaaatatact tactctgtgc ttgtgtatgt gaatgttaat gcaactatta cctagagtga   5100

actttaagct ttattgttga atgtaattcc attatatttc cttttgtaca cctgtgaaaa   5160

agtggagtag tgttttttta accattgtta atcagctttt gtgtatgaaa gacacagtaa   5220

aatttctttc ttaaatcaag atactggtga ttcaaggaat tttatttatg gtccagccaa   5280

gagccatctc gtgccaagac ttctgctggc aagggaatgg ataaagctgt tttgttctag   5340

taacaatttt ggaatgaata ctgacaatat tccatgaggg tgtgcaagca caaattttac   5400

caatctgacc tctttgaagt tgcagaatgc tttgaaattc taatggtatc tgaaatatca   5460

gctcatagaa agtaacaaaa tttgctgtca ccttaaataa gacattttaa ttttgttata   5520

atgtacaatt tagaagtttg attaattata ttatctattt aggcattaat ataaaagagg   5580

taggagtctg ttatttaaaa aaagcattaa atttaaaaaa aaactgtctt gtctactttt   5640

agcttcattc tcccatattt tgaagggtgt gtaacttcag ctctgcagga ttgcatgggg   5700

taaaacttgt taccaacaca tgtgaaccat tgctacattg taggttgtga tcattttgcc   5760

ccactgaagc ccatgtatct gaccttacgt gccttttgaa ctaggagaat cgggctaatt   5820

tattaatgat gataattata atgtatctgt acagcacttt ttacatttgc gaagtgcttt   5880

ccaatccatg ttagttacta gttattacag ctgtaaggat aaaacacgtc atgtggattc   5940

attttgaatt ggtgctattg gtatttcctc tgttattgct aataaatgaa aatggtggta   6000

tgaaa                                                               6005


<210>  2215
<211>  963
<212>  PRT
<213>  Homo sapiens

<400>  2215


Met Val Gly Cys Gly Val Ala Val Leu Cys Leu Trp Val Ser Cys Gly 
1               5                   10                  15      


Ala Ala Ala Gly Gln Leu Glu Tyr Ser Val Pro Glu Glu Thr Glu Arg 
            20                  25                  30          


Gly Val Ala Val Gly Asn Leu Ser Ala Asp Leu Arg Leu Pro Ala Ala 
        35                  40                  45              


Ala Met Ser Ser Arg Asn Phe Arg Phe Leu Ser Ser His Arg Glu Leu 
    50                  55                  60                  


Tyr Phe Gly Val Asp Leu Pro Ser Gly Asn Leu Val Val Arg Glu Pro 
65                  70                  75                  80  


Ala Asp Arg Glu Gln Leu Cys Arg Ala Lys Ala Ala Cys Val Leu Thr 
                85                  90                  95      


Tyr Asp Leu Val Leu Glu Asp Pro Leu Glu Leu His Lys Ile Arg Ile 
            100                 105                 110         


His Val Leu Asp Thr Asn Asp Asn Ser Pro Leu Phe Pro Ala Gly Asp 
        115                 120                 125             


Val Gln Leu His Ile Pro Glu Phe Leu Thr Pro Gly Ala Arg Phe Thr 
    130                 135                 140                 


Leu Pro Asn Ala Gln Asp Asp Asp Glu Gly Ser Asn Gly Ile Leu Ser 
145                 150                 155                 160 


Tyr Ser Leu Ser Pro Ser Gln His Phe Arg Leu Asp Met Gly Ser Arg 
                165                 170                 175     


Val Asp Gly Ser Glu Tyr Pro Glu Leu Val Leu Glu Lys Ala Leu Asp 
            180                 185                 190         


Arg Glu Gln Arg Ala Thr His Leu Leu Val Leu Thr Ala Arg Asp Gly 
        195                 200                 205             


Gly Leu Pro Ala Arg Ser Gly Asp Ala Gln Val Thr Ile Ile Val Val 
    210                 215                 220                 


Asp Thr Asn Asp Asn Ala Pro Val Phe Glu Arg Ser Val Tyr Arg Thr 
225                 230                 235                 240 


Lys Val Pro Glu Thr Ala Pro Asn Gly Thr Val Leu Phe Arg Val Gln 
                245                 250                 255     


Ala Leu Asp Pro Asp Glu Gly Ser Asn Gly Glu Val Gln Tyr Ser Leu 
            260                 265                 270         


Ser Asn Ser Thr Gln Ala Glu Leu Arg His Arg Phe His Val His Pro 
        275                 280                 285             


Lys Ser Gly Glu Val Gln Val Ala Ala Ser Leu Gly Pro Pro Glu Thr 
    290                 295                 300                 


Leu Leu Glu Ala Tyr Ile Glu Ala Arg Asp Glu Gly Val Phe Gly Leu 
305                 310                 315                 320 


Ala Ser Thr Ala Lys Leu Leu Val Glu Val Thr Asp Val Asn Asp His 
                325                 330                 335     


Ala Pro Glu Leu Asp Phe Leu Thr Leu Ser Asn Pro Val Pro Glu Asp 
            340                 345                 350         


Ala Ala Pro Gly Thr Val Ile Ala Leu Phe Ser Val Lys Asp Glu Asp 
        355                 360                 365             


Leu Asp Ser Asn Gly Arg Val Ile Cys Gly Met Ser Ser Ala Gly Pro 
    370                 375                 380                 


Phe Gln Leu Thr Ala Ser Phe Asp Asn Tyr Tyr Ser Leu Leu Ile Asp 
385                 390                 395                 400 


Gly Pro Leu Asp Arg Glu Gln Ile Ser Glu Tyr Gln Val Leu Ile Thr 
                405                 410                 415     


Ala Ser Asp Ser Gly Ser Pro Pro Leu Ser Thr Arg Arg Thr Ile Thr 
            420                 425                 430         


Val Ser Val Ala Asp Val Asn Asp Asn Thr Pro Asn Phe Pro Gln Pro 
        435                 440                 445             


Gln Gln Glu Leu Phe Val Ala Glu Asn Asn Gly Pro Gly Ala Ser Leu 
    450                 455                 460                 


Gly Arg Val Phe Ala Gln Asp Pro Asp Leu Gly Lys Asn Gly Leu Val 
465                 470                 475                 480 


Ser Tyr Glu Leu Leu Asp Val Ile Ser Glu Gly Pro Ser Ala Ser Ser 
                485                 490                 495     


Leu Leu Ala Val Glu Ser Ser Ser Gly Ala Ile Thr Ala Lys Thr Ser 
            500                 505                 510         


Phe Asp Phe Glu Gln Leu Arg Gly Phe His Phe Gln Val Glu Gly Arg 
        515                 520                 525             


Asp Gly Gly Ile Pro Pro Arg Ser Ala Thr Val Thr Ile Asn Leu Phe 
    530                 535                 540                 


Val Val Asp Arg Asn Asp Asn Tyr Pro Val Ile Leu Phe Pro Leu Pro 
545                 550                 555                 560 


Arg Asn Gly Ser Val Pro Val Glu Ile Val Pro Arg Ser Ala Arg Thr 
                565                 570                 575     


Gly His Leu Val Thr Lys Val Val Ala Glu Asp Ala Asp Ser Gly Ser 
            580                 585                 590         


Asn Ala Trp Leu Ser Tyr His Ile Ser Arg Ala Ser Asp Ser Ser Leu 
        595                 600                 605             


Phe Arg Ile Ser Ala Asn Ile Gly Glu Leu Arg Thr Ala Arg Leu Val 
    610                 615                 620                 


Leu Pro Thr Asp Ala Val Lys Gln Arg Val Val Val Val Val Arg Asp 
625                 630                 635                 640 


His Gly Asp Pro Pro Leu Ser Ser Ser Val Thr Leu Gly Val Leu Leu 
                645                 650                 655     


Ser Asn Ser Val Pro Gln Leu Leu Pro Asp Phe Glu Asp Val Trp Glu 
            660                 665                 670         


Pro Gly Gly Gln Leu Ser Ala Gln Asn Leu Tyr Leu Val Ile Ala Leu 
        675                 680                 685             


Ala Cys Ile Ser Phe Leu Phe Leu Gly Cys Leu Leu Phe Phe Val Cys 
    690                 695                 700                 


Thr Lys Leu His Gln Ser Pro Gly Cys Cys Ala Gln Ser Cys Cys Arg 
705                 710                 715                 720 


Ser Thr Glu Asp Leu Arg Tyr Gly Ser Lys Met Val Ser Asn Pro Cys 
                725                 730                 735     


Met Thr Ser Ala Thr Ile Asp Val Thr Thr Val Glu Arg Leu Ser Gln 
            740                 745                 750         


Thr Tyr Leu Tyr Arg Ala Ser Leu Gly Leu Gly Ser Asp Asn Asn Ser 
        755                 760                 765             


Leu Leu Leu Arg Gly Glu Tyr Asn Ala Ala Asp Leu Arg Asn Leu Ala 
    770                 775                 780                 


Thr Gly Val Gly Leu Asn Leu Pro Ile Ser Cys Ile Gln Ile Arg Asn 
785                 790                 795                 800 


Arg Lys Gly Asp His Ala Asn Val Asn Ala Met Pro Arg Gln Pro Asn 
                805                 810                 815     


Pro Asp Trp Arg Tyr Ser Ala Ser Leu Arg Ala Gly Met His Ser Ser 
            820                 825                 830         


Val His Leu Glu Glu Ala Gly Ile Leu Arg Ala Gly Pro Gly Gly Pro 
        835                 840                 845             


Asp Gln Gln Trp Pro Thr Val Ser Ser Ala Thr Pro Glu Pro Glu Ala 
    850                 855                 860                 


Gly Glu Val Ser Pro Pro Val Gly Ala Gly Val Asn Ser Asn Ser Trp 
865                 870                 875                 880 


Thr Phe Lys Tyr Gly Pro Gly Asn Pro Lys Gln Ser Gly Pro Gly Glu 
                885                 890                 895     


Leu Pro Asp Lys Phe Ile Ile Pro Gly Ser Pro Ala Ile Ile Ser Ile 
            900                 905                 910         


Arg Gln Glu Pro Thr Asn Ser Gln Ile Asp Lys Ser Asp Phe Ile Thr 
        915                 920                 925             


Phe Gly Lys Lys Glu Glu Thr Lys Lys Lys Lys Lys Lys Lys Lys Gly 
    930                 935                 940                 


Asn Lys Thr Gln Glu Lys Lys Glu Lys Gly Asn Ser Thr Thr Asp Asn 
945                 950                 955                 960 


Ser Asp Gln 
            

<210>  2216
<211>  5349
<212>  DNA
<213>  Homo sapiens

<400>  2216
aatgttagat ccgccgcctg ggtgcccata cttagctaag gcccctcagt ttattttcct     60

gaattgcgct tggagatctt ttcctgggga gctgatagcc agacttctag gggcttgact    120

gcttttccca gactaatctc cttaaagacc cgttaagcag gggagagacg gtggagactg    180

gatgaactgg acagtggggg tagggagaaa gggagtggcc gtgttcctgc ggtccgctgg    240

gatccggcag gtccagggtg aaggagatgg ggctggagag gctgagcagt ccgggttcgc    300

tgtccgccac ttcggcgcgg aatcagagca ggacttgctg agccctccta ccgctccctt    360

tccccctccc cctctgtctt cccttctgtt tccttttccc tccccctgga gctgtagcgg    420

cagcagcagc aggaagccga gccgggttga gcgactcgga ggcgagcgga ggagctggaa    480

tatggggagt cagcgaggac ggtggggcca ggagcccttg ggagggccta cggagggagc    540

ggccccaggc gctttctaga gcgtgagcgg tgggggagca ggcgcagggt ggcacgagcg    600

gaggcggggc ccgggcgtgg ggcacggctg gggaagctgc cgcctccggc cctgcccggc    660

tgcctccgcc gcggccagtg gctatggagc aggcgggcac cagacctgcg gcgacagagc    720

atccacggct ccggcggccc atgccctggc tgctgctact gcctctcctg ctgctgttgc    780

tgctgctgct acctggccct gcggcctccc agctgcgata ctctgtgcca gaggagcagg    840

cacccggcgc gctcgtgggc aacgtggctc gcgcgctggg gcttgagctg cggcgcttgg    900

ggccgggttg cttgcgcatc aaccatctgg gtgcgcccag tccgcgctac ctggagctgg    960

acctgacgag tggagcgctc ttcgtcaacg agcgcattga tcgggaggcg ctgtgtgagc   1020

agcggcctcg ctgcctgctc agcttggaag tgctggcgca caaccccgtg gcggtgagcg   1080

ccgttgaggt ggaaatattg gacatcaacg acaactcacc gcgtttcccg cggcccaact   1140

accagcttca ggtaagcgaa tcggtggcgc ctggagcgcg ctttcacata gagagtgcgc   1200

aggaccccga cgtgggcgcc aactcagtac agacctacga gctcagcccc agcgagcact   1260

tcgagctgga ccttaagccc ctgcaggaga acagtaaagt gcttgagctg gtgctgcgta   1320

agggcctaga ccgggagcag gcagccttgc accacctggt tctcacagcc gtggatgggg   1380

gcatcccagc ccgctcgggt acggcacaga tctctgtgcg tgtcctggac actaacgaca   1440

actctcctgc ctttgaccag tccacttatc gcgtccagct acgggaggac tcacccccag   1500

gcacattggt ggtgaagctg aatgcctcag acccggatga gggctccaat ggtgagctca   1560

ggtactcctt gagcagctac acgtcggacc gggagaggca gctcttcagc atagatgcca   1620

gtaccgggga agtgcgagta attggggggc tggattatga ggaagcctcc tcctaccaga   1680

tctatgtgca ggcgactgac cggggtccag tgcccatggc aggtcactgc aaggtgctgg   1740

tggacatcgt ggacgtgaat gacaatgccc cagaggtggt gctcacggac ctgtatagcc   1800

cagtgcctga gaatgctaca cccaacacca ttgtggccgt tctcagtgtc aatgaccaag   1860

actcaggccc caaccggaaa gtgagcctgg gtctggaggc cacactgcct ttccgactga   1920

atggctttgg aaactcctat acactggtgg tgagcggccc actggaccga gagcgggtgg   1980

ctgtctacaa catcacggtg acagccacag atgggggaat accgcagctc acatccctgc   2040

gtacactgaa ggttgagatc tctgacatca atgacaatcc accaagcttc ctggaggact   2100

cctattccat ctacatacag gagaacaatt tgccaggtgt gttgctctgt actgtgcaag   2160

ccacagaccc agatgaaaag gagaatgcag aggtgaccta ctcccttctg gagagggaga   2220

ttcaagggct gccagtcacc tcctatgtct ccattaacag tgccagtggc agcctttatg   2280

ctgtcaactc ctttgactat gagaagtttc gggagttctt tgtgactgtg gaggctcagg   2340

acaaggggag cccaccactg agcagcactg tgactgccaa cgtatatgtg gtggacatga   2400

atgaccatgc ccctcacatt ctgtacccta cctcaaccaa ctcgtcagca gccttcgaga   2460

tggtgcctcg aactgcccct gctggctacc tggtcaccaa agtcatagct atggactcag   2520

actctgggca aaatgcttgg cttttttacc atctagccca gacttctgac ctggacctct   2580

ttaaggtaga gctgcacaca ggagaaatta ggactaccag gaagatggga gatgagagtg   2640

gtagcacttt caacctgacc gtggtggtcc gagataatgg agagccatca ctatcagcct   2700

ctgtggccat tacagtagct gtggtggata gggtttccaa aatcctccct gacactcaga   2760

ggcatgttaa gagccctcgg acatactctg aaattaccct ttatctaata atagcattaa   2820

gcacagtgtc ttttatattt cttttgacaa tcatcatttt gagcatcatc aagtgctacc   2880

gctacactgc gtatggcact gcatgctgtg gaggcttctg tggagtaagg gaaaggtccc   2940

ctgcagaact gtacaaacaa gccaacaaca atattgatgc caggataccg catggcctca   3000

aagtgcagcc tcacttcatt gaagttcgag ggaatggctc cctcaccaag acctactgct   3060

acaaggcctg tctgacagca ggctcaggga gtgacacttt catgttttac aatacagggg   3120

cccagacagg accagggcct tcgggagccc aagcagcagt gactgacagc aggaatctca   3180

caggccaaag tggtcagaat gctgggaacc tgattattct caaaaatgag gctgtttctc   3240

aaaatgagcc acgacagccc aaccctgact ggcgttactc tgcctccctg agagcaggca   3300

tgcacagctc tgtgcaccta gaggaggctg gcattctacg ggctggtcca ggagggcctg   3360

atcagcagtg gccaacagta tccagtgcaa caccagaacc agaggcagga gaagtgtccc   3420

ctccagtcgg tgcgggtgtc aacagcaaca gctggacctt taaatacgga ccaggcaacc   3480

ccaaacaatc cggtcccggt gagttgcccg acaaattcat tatcccagga tctcctgcaa   3540

tcatctccat ccggcaggag cctactaaca gccaaattga caaaagtgac ttcataacct   3600

tcggcaaaaa ggaggagacc aagaaaaaga agaaaaagaa gaagggtaac aagacccagg   3660

agaaaaaaga gaaagggaac agcacgactg acaacagtga ccagtgaggt cctcaaatgg   3720

aaacaagcca cttagccagt ttttgtaata atggcaaatc tctcccatgt agcaattccc   3780

tgctcctttt tcctatctac atgagccctc ttagagacct cagaaatctg cagaaagttc   3840

cctgtgtctg tctagaacgc atttaacagg ttttgtcgta aaagctttac taagtctggt   3900

gttaactctt tctctccact ctggcttgtt ttcagaacct aaaaagcaga cccaagtttc   3960

ctttctcctc cgccgcaaag gagaggcttc ccagccccgc cagtgagagg ttggactctc   4020

tgccctgtgc tccggggatc ctgtcttgat gacacttgca gggcaggctg aaaagttttg   4080

agattgagca gcttgggagt ttgtggccac tgggtatgtg tggctaccgc gggtatgcga   4140

gtgccagata ttggctgaga cgagccagct tagactaatt ggtacaagga aggcaagaaa   4200

acaaagacaa ataaacagcg gaagttatca gtatggaggg gaagtgtaaa cttaaaggga   4260

ccagactttc taaatcttac aactcaagag gtggcagcca ccctctagga gacaaaacta   4320

cccccactga caaggcttta ggagacccta aagtctgttg gctgtgacgt cattatacct   4380

aaaatctgca tcatacctgc aagccaacag ttcagtgttt taacagagaa ccaccctggg   4440

aaacagaagc agatctgatg tgtttcctat acatgtcctg tgctcacttt attaaaaatt   4500

cttttgcaca caatgtttat gaaaaggcca gatccttttc caatacttat gcaaaagcaa   4560

aagaaaaccc cgacacctca cctttcgctg tttgttgttt catagattta tttaaaaaaa   4620

gagaaagtct atagctataa atctttaaag agaaatatga atacaattcc cctaaactct   4680

cctcaaaaga gaattcagtc tacagccatt taaatgatca ttgctgctac agaagtgctt   4740

taagagaatt gcctgaaaca tctgtattat atcggccacc tgccaatcac agctttactc   4800

tttcaggtca ctctggggct gcctcttgca tgtattacta aataaaatga tctctctttc   4860

tctctctctc tctcttttct aagaaacaat tatgtgcact ttgatacaca accttctcta   4920

accaactata tatcaagacc caaaaattga agaaaaatat tgttttctca tacagtgagc   4980

agatttttca atctactaat tctgtgactt gtcttggtgt gctagcctac accttctctt   5040

tggtttagtt ttccttttct ataacactct gaattgctaa tcttactaac acctatgatg   5100

ttacctgaaa tcaatctccc atatgtatgc tgtatgctat gctaagactc ctgaaatata   5160

cttactctgt gcttgtgtat gtgaatgtta atgcaactat tacctagagt gaactttaag   5220

ctttattgtt gaatgtaatt ccattatatt tccttttgta cacctgtgaa aaagtggagt   5280

agtgtttttt taaccattgt taatcagctt ttgtgtatga aagacacagt aaaatttctt   5340

tcttaaatc                                                           5349


<210>  2217
<211>  1007
<212>  PRT
<213>  Homo sapiens

<400>  2217


Met Glu Gln Ala Gly Thr Arg Pro Ala Ala Thr Glu His Pro Arg Leu 
1               5                   10                  15      


Arg Arg Pro Met Pro Trp Leu Leu Leu Leu Pro Leu Leu Leu Leu Leu 
            20                  25                  30          


Leu Leu Leu Leu Pro Gly Pro Ala Ala Ser Gln Leu Arg Tyr Ser Val 
        35                  40                  45              


Pro Glu Glu Gln Ala Pro Gly Ala Leu Val Gly Asn Val Ala Arg Ala 
    50                  55                  60                  


Leu Gly Leu Glu Leu Arg Arg Leu Gly Pro Gly Cys Leu Arg Ile Asn 
65                  70                  75                  80  


His Leu Gly Ala Pro Ser Pro Arg Tyr Leu Glu Leu Asp Leu Thr Ser 
                85                  90                  95      


Gly Ala Leu Phe Val Asn Glu Arg Ile Asp Arg Glu Ala Leu Cys Glu 
            100                 105                 110         


Gln Arg Pro Arg Cys Leu Leu Ser Leu Glu Val Leu Ala His Asn Pro 
        115                 120                 125             


Val Ala Val Ser Ala Val Glu Val Glu Ile Leu Asp Ile Asn Asp Asn 
    130                 135                 140                 


Ser Pro Arg Phe Pro Arg Pro Asn Tyr Gln Leu Gln Val Ser Glu Ser 
145                 150                 155                 160 


Val Ala Pro Gly Ala Arg Phe His Ile Glu Ser Ala Gln Asp Pro Asp 
                165                 170                 175     


Val Gly Ala Asn Ser Val Gln Thr Tyr Glu Leu Ser Pro Ser Glu His 
            180                 185                 190         


Phe Glu Leu Asp Leu Lys Pro Leu Gln Glu Asn Ser Lys Val Leu Glu 
        195                 200                 205             


Leu Val Leu Arg Lys Gly Leu Asp Arg Glu Gln Ala Ala Leu His His 
    210                 215                 220                 


Leu Val Leu Thr Ala Val Asp Gly Gly Ile Pro Ala Arg Ser Gly Thr 
225                 230                 235                 240 


Ala Gln Ile Ser Val Arg Val Leu Asp Thr Asn Asp Asn Ser Pro Ala 
                245                 250                 255     


Phe Asp Gln Ser Thr Tyr Arg Val Gln Leu Arg Glu Asp Ser Pro Pro 
            260                 265                 270         


Gly Thr Leu Val Val Lys Leu Asn Ala Ser Asp Pro Asp Glu Gly Ser 
        275                 280                 285             


Asn Gly Glu Leu Arg Tyr Ser Leu Ser Ser Tyr Thr Ser Asp Arg Glu 
    290                 295                 300                 


Arg Gln Leu Phe Ser Ile Asp Ala Ser Thr Gly Glu Val Arg Val Ile 
305                 310                 315                 320 


Gly Gly Leu Asp Tyr Glu Glu Ala Ser Ser Tyr Gln Ile Tyr Val Gln 
                325                 330                 335     


Ala Thr Asp Arg Gly Pro Val Pro Met Ala Gly His Cys Lys Val Leu 
            340                 345                 350         


Val Asp Ile Val Asp Val Asn Asp Asn Ala Pro Glu Val Val Leu Thr 
        355                 360                 365             


Asp Leu Tyr Ser Pro Val Pro Glu Asn Ala Thr Pro Asn Thr Ile Val 
    370                 375                 380                 


Ala Val Leu Ser Val Asn Asp Gln Asp Ser Gly Pro Asn Arg Lys Val 
385                 390                 395                 400 


Ser Leu Gly Leu Glu Ala Thr Leu Pro Phe Arg Leu Asn Gly Phe Gly 
                405                 410                 415     


Asn Ser Tyr Thr Leu Val Val Ser Gly Pro Leu Asp Arg Glu Arg Val 
            420                 425                 430         


Ala Val Tyr Asn Ile Thr Val Thr Ala Thr Asp Gly Gly Ile Pro Gln 
        435                 440                 445             


Leu Thr Ser Leu Arg Thr Leu Lys Val Glu Ile Ser Asp Ile Asn Asp 
    450                 455                 460                 


Asn Pro Pro Ser Phe Leu Glu Asp Ser Tyr Ser Ile Tyr Ile Gln Glu 
465                 470                 475                 480 


Asn Asn Leu Pro Gly Val Leu Leu Cys Thr Val Gln Ala Thr Asp Pro 
                485                 490                 495     


Asp Glu Lys Glu Asn Ala Glu Val Thr Tyr Ser Leu Leu Glu Arg Glu 
            500                 505                 510         


Ile Gln Gly Leu Pro Val Thr Ser Tyr Val Ser Ile Asn Ser Ala Ser 
        515                 520                 525             


Gly Ser Leu Tyr Ala Val Asn Ser Phe Asp Tyr Glu Lys Phe Arg Glu 
    530                 535                 540                 


Phe Phe Val Thr Val Glu Ala Gln Asp Lys Gly Ser Pro Pro Leu Ser 
545                 550                 555                 560 


Ser Thr Val Thr Ala Asn Val Tyr Val Val Asp Met Asn Asp His Ala 
                565                 570                 575     


Pro His Ile Leu Tyr Pro Thr Ser Thr Asn Ser Ser Ala Ala Phe Glu 
            580                 585                 590         


Met Val Pro Arg Thr Ala Pro Ala Gly Tyr Leu Val Thr Lys Val Ile 
        595                 600                 605             


Ala Met Asp Ser Asp Ser Gly Gln Asn Ala Trp Leu Phe Tyr His Leu 
    610                 615                 620                 


Ala Gln Thr Ser Asp Leu Asp Leu Phe Lys Val Glu Leu His Thr Gly 
625                 630                 635                 640 


Glu Ile Arg Thr Thr Arg Lys Met Gly Asp Glu Ser Gly Ser Thr Phe 
                645                 650                 655     


Asn Leu Thr Val Val Val Arg Asp Asn Gly Glu Pro Ser Leu Ser Ala 
            660                 665                 670         


Ser Val Ala Ile Thr Val Ala Val Val Asp Arg Val Ser Lys Ile Leu 
        675                 680                 685             


Pro Asp Thr Gln Arg His Val Lys Ser Pro Arg Thr Tyr Ser Glu Ile 
    690                 695                 700                 


Thr Leu Tyr Leu Ile Ile Ala Leu Ser Thr Val Ser Phe Ile Phe Leu 
705                 710                 715                 720 


Leu Thr Ile Ile Ile Leu Ser Ile Ile Lys Cys Tyr Arg Tyr Thr Ala 
                725                 730                 735     


Tyr Gly Thr Ala Cys Cys Gly Gly Phe Cys Gly Val Arg Glu Arg Ser 
            740                 745                 750         


Pro Ala Glu Leu Tyr Lys Gln Ala Asn Asn Asn Ile Asp Ala Arg Ile 
        755                 760                 765             


Pro His Gly Leu Lys Val Gln Pro His Phe Ile Glu Val Arg Gly Asn 
    770                 775                 780                 


Gly Ser Leu Thr Lys Thr Tyr Cys Tyr Lys Ala Cys Leu Thr Ala Gly 
785                 790                 795                 800 


Ser Gly Ser Asp Thr Phe Met Phe Tyr Asn Thr Gly Ala Gln Thr Gly 
                805                 810                 815     


Pro Gly Pro Ser Gly Ala Gln Ala Ala Val Thr Asp Ser Arg Asn Leu 
            820                 825                 830         


Thr Gly Gln Ser Gly Gln Asn Ala Gly Asn Leu Ile Ile Leu Lys Asn 
        835                 840                 845             


Glu Ala Val Ser Gln Asn Glu Pro Arg Gln Pro Asn Pro Asp Trp Arg 
    850                 855                 860                 


Tyr Ser Ala Ser Leu Arg Ala Gly Met His Ser Ser Val His Leu Glu 
865                 870                 875                 880 


Glu Ala Gly Ile Leu Arg Ala Gly Pro Gly Gly Pro Asp Gln Gln Trp 
                885                 890                 895     


Pro Thr Val Ser Ser Ala Thr Pro Glu Pro Glu Ala Gly Glu Val Ser 
            900                 905                 910         


Pro Pro Val Gly Ala Gly Val Asn Ser Asn Ser Trp Thr Phe Lys Tyr 
        915                 920                 925             


Gly Pro Gly Asn Pro Lys Gln Ser Gly Pro Gly Glu Leu Pro Asp Lys 
    930                 935                 940                 


Phe Ile Ile Pro Gly Ser Pro Ala Ile Ile Ser Ile Arg Gln Glu Pro 
945                 950                 955                 960 


Thr Asn Ser Gln Ile Asp Lys Ser Asp Phe Ile Thr Phe Gly Lys Lys 
                965                 970                 975     


Glu Glu Thr Lys Lys Lys Lys Lys Lys Lys Lys Gly Asn Lys Thr Gln 
            980                 985                 990         


Glu Lys Lys Glu Lys Gly Asn Ser  Thr Thr Asp Asn Ser  Asp Gln 
        995                 1000                 1005         

<210>  2218
<211>  6117
<212>  DNA
<213>  Homo sapiens

<400>  2218
aatgttagat ccgccgcctg ggtgcccata cttagctaag gcccctcagt ttattttcct     60

gaattgcgct tggagatctt ttcctgggga gctgatagcc agacttctag gggcttgact    120

gcttttccca gactaatctc cttaaagacc cgttaagcag gggagagacg gtggagactg    180

gatgaactgg acagtggggg tagggagaaa gggagtggcc gtgttcctgc ggtccgctgg    240

gatccggcag gtccagggtg aaggagatgg ggctggagag gctgagcagt ccgggttcgc    300

tgtccgccac ttcggcgcgg aatcagagca ggacttgctg agccctccta ccgctccctt    360

tccccctccc cctctgtctt cccttctgtt tccttttccc tccccctgga gctgtagcgg    420

cagcagcagc aggaagccga gccgggttga gcgactcgga ggcgagcgga ggagctggaa    480

tatggggagt cagcgaggac ggtggggcca ggagcccttg ggagggccta cggagggagc    540

ggccccaggc gctttctaga gcgtgagcgg tgggggagca ggcgcagggt ggcacgagcg    600

gaggcggggc ccgggcgtgg ggcacggctg gggaagctgc cgcctccggc cctgcccggc    660

tgcctccgcc gcggccagtg gctatggagc aggcgggcac cagacctgcg gcgacagagc    720

atccacggct ccggcggccc atgccctggc tgctgctact gcctctcctg ctgctgttgc    780

tgctgctgct acctggccct gcggcctccc agctgcgata ctctgtgcca gaggagcagg    840

cacccggcgc gctcgtgggc aacgtggctc gcgcgctggg gcttgagctg cggcgcttgg    900

ggccgggttg cttgcgcatc aaccatctgg gtgcgcccag tccgcgctac ctggagctgg    960

acctgacgag tggagcgctc ttcgtcaacg agcgcattga tcgggaggcg ctgtgtgagc   1020

agcggcctcg ctgcctgctc agcttggaag tgctggcgca caaccccgtg gcggtgagcg   1080

ccgttgaggt ggaaatattg gacatcaacg acaactcacc gcgtttcccg cggcccaact   1140

accagcttca ggtaagcgaa tcggtggcgc ctggagcgcg ctttcacata gagagtgcgc   1200

aggaccccga cgtgggcgcc aactcagtac agacctacga gctcagcccc agcgagcact   1260

tcgagctgga ccttaagccc ctgcaggaga acagtaaagt gcttgagctg gtgctgcgta   1320

agggcctaga ccgggagcag gcagccttgc accacctggt tctcacagcc gtggatgggg   1380

gcatcccagc ccgctcgggt acggcacaga tctctgtgcg tgtcctggac actaacgaca   1440

actctcctgc ctttgaccag tccacttatc gcgtccagct acgggaggac tcacccccag   1500

gcacattggt ggtgaagctg aatgcctcag acccggatga gggctccaat ggtgagctca   1560

ggtactcctt gagcagctac acgtcggacc gggagaggca gctcttcagc atagatgcca   1620

gtaccgggga agtgcgagta attggggggc tggattatga ggaagcctcc tcctaccaga   1680

tctatgtgca ggcgactgac cggggtccag tgcccatggc aggtcactgc aaggtgctgg   1740

tggacatcgt ggacgtgaat gacaatgccc cagaggtggt gctcacggac ctgtatagcc   1800

cagtgcctga gaatgctaca cccaacacca ttgtggccgt tctcagtgtc aatgaccaag   1860

actcaggccc caaccggaaa gtgagcctgg gtctggaggc cacactgcct ttccgactga   1920

atggctttgg aaactcctat acactggtgg tgagcggccc actggaccga gagcgggtgg   1980

ctgtctacaa catcacggtg acagccacag atgggggaat accgcagctc acatccctgc   2040

gtacactgaa ggttgagatc tctgacatca atgacaatcc accaagcttc ctggaggact   2100

cctattccat ctacatacag gagaacaatt tgccaggtgt gttgctctgt actgtgcaag   2160

ccacagaccc agatgaaaag gagaatgcag aggtgaccta ctcccttctg gagagggaga   2220

ttcaagggct gccagtcacc tcctatgtct ccattaacag tgccagtggc agcctttatg   2280

ctgtcaactc ctttgactat gagaagtttc gggagttctt tgtgactgtg gaggctcagg   2340

acaaggggag cccaccactg agcagcactg tgactgccaa cgtatatgtg gtggacatga   2400

atgaccatgc ccctcacatt ctgtacccta cctcaaccaa ctcgtcagca gccttcgaga   2460

tggtgcctcg aactgcccct gctggctacc tggtcaccaa agtcatagct atggactcag   2520

actctgggca aaatgcttgg cttttttacc atctagccca gacttctgac ctggacctct   2580

ttaaggtaga gctgcacaca ggagaaatta ggactaccag gaagatggga gatgagagtg   2640

gtagcacttt caacctgacc gtggtggtcc gagataatgg agagccatca ctatcagcct   2700

ctgtggccat tacagtagct gtggtggata gggtttccaa aatcctccct gacactcaga   2760

ggcatgttaa gagccctcgg acatactctg aaattaccct ttatctaata atagcattaa   2820

gcacagtgtc ttttatattt cttttgacaa tcatcatttt gagcatcatc aagtgctacc   2880

gctacactgc gtatggcact gcatgctgtg gaggcttctg tggagtaagg gaaaggtccc   2940

ctgcagaact gtacaaacaa gccaacaaca atattgatgc caggataccg catggcctca   3000

aagtgcagcc tcacttcatt gaagttcgag ggaatggctc cctcaccaag acctactgct   3060

acaaggcctg tctgacagca ggctcaggga gtgacacttt catgttttac aatacagggg   3120

cccagacagg accagggcct tcgggagccc aagcagcagt gactgacagc aggaatctca   3180

caggccaaag tggtcagaat gctgggaacc tgattattct caaaaatgag gctgtttctc   3240

aaaatgagcc acgacagccc aaccctgact ggcgttactc tgcctccctg agagcaggca   3300

tgcacagctc tgtgcaccta gaggaggctg gcattctacg ggctggtcca ggagggcctg   3360

atcagcagtg gccaacagta tccagtgcaa caccagaacc agaggcagga gaagtgtccc   3420

ctccagtcgg tgcgggtgtc aacagcaaca gctggacctt taaatacgga ccaggcaacc   3480

ccaaacaatc cggtcccggt gagttgcccg acaaattcat tatcccagga tctcctgcaa   3540

tcatctccat ccggcaggag cctactaaca gccaaattga caaaagtgac ttcataacct   3600

tcggcaaaaa ggaggagacc aagaaaaaga agaaaaagaa gaagggtaac aagacccagg   3660

agaaaaaaga gaaagggaac agcacgactg acaacagtga ccagtgaggt cctcaaatgg   3720

aaacaagcca cttagccagt ttttgtaata atggcaaatc tctcccatgt agcaattccc   3780

tgctcctttt tcctatctac atgagccctc ttagagacct cagaaatctg cagaaagttc   3840

cctgtgtctg tctagaacgc atttaacagg ttttgtcgta aaagctttac taagtctggt   3900

gttaactctt tctctccact ctggcttgtt ttcagaacct aaaaagcaga cccaagtttc   3960

ctttctcctc cgccgcaaag gagaggcttc ccagccccgc cagtgagagg ttggactctc   4020

tgccctgtgc tccggggatc ctgtcttgat gacacttgca gggcaggctg aaaagttttg   4080

agattgagca gcttgggagt ttgtggccac tgggtatgtg tggctaccgc gggtatgcga   4140

gtgccagata ttggctgaga cgagccagct tagactaatt ggtacaagga aggcaagaaa   4200

acaaagacaa ataaacagcg gaagttatca gtatggaggg gaagtgtaaa cttaaaggga   4260

ccagactttc taaatcttac aactcaagag gtggcagcca ccctctagga gacaaaacta   4320

cccccactga caaggcttta ggagacccta aagtctgttg gctgtgacgt cattatacct   4380

aaaatctgca tcatacctgc aagccaacag ttcagtgttt taacagagaa ccaccctggg   4440

aaacagaagc agatctgatg tgtttcctat acatgtcctg tgctcacttt attaaaaatt   4500

cttttgcaca caatgtttat gaaaaggcca gatccttttc caatacttat gcaaaagcaa   4560

aagaaaaccc cgacacctca cctttcgctg tttgttgttt catagattta tttaaaaaaa   4620

gagaaagtct atagctataa atctttaaag agaaatatga atacaattcc cctaaactct   4680

cctcaaaaga gaattcagtc tacagccatt taaatgatca ttgctgctac agaagtgctt   4740

taagagaatt gcctgaaaca tctgtattat atcggccacc tgccaatcac agctttactc   4800

tttcaggtca ctctggggct gcctcttgca tgtattacta aataaaatga tctctctttc   4860

tctctctctc tctcttttct aagaaacaat tatgtgcact ttgatacaca accttctcta   4920

accaactata tatcaagacc caaaaattga agaaaaatat tgttttctca tacagtgagc   4980

agatttttca atctactaat tctgtgactt gtcttggtgt gctagcctac accttctctt   5040

tggtttagtt ttccttttct ataacactct gaattgctaa tcttactaac acctatgatg   5100

ttacctgaaa tcaatctccc atatgtatgc tgtatgctat gctaagactc ctgaaatata   5160

cttactctgt gcttgtgtat gtgaatgtta atgcaactat tacctagagt gaactttaag   5220

ctttattgtt gaatgtaatt ccattatatt tccttttgta cacctgtgaa aaagtggagt   5280

agtgtttttt taaccattgt taatcagctt ttgtgtatga aagacacagt aaaatttctt   5340

tcttaaatca agatactggt gattcaagga attttattta tggtccagcc aagagccatc   5400

tcgtgccaag acttctgctg gcaagggaat ggataaagct gttttgttct agtaacaatt   5460

ttggaatgaa tactgacaat attccatgag ggtgtgcaag cacaaatttt accaatctga   5520

cctctttgaa gttgcagaat gctttgaaat tctaatggta tctgaaatat cagctcatag   5580

aaagtaacaa aatttgctgt caccttaaat aagacatttt aattttgtta taatgtacaa   5640

tttagaagtt tgattaatta tattatctat ttaggcatta atataaaaga ggtaggagtc   5700

tgttatttaa aaaaagcatt aaatttaaaa aaaaactgtc ttgtctactt ttagcttcat   5760

tctcccatat tttgaagggt gtgtaacttc agctctgcag gattgcatgg ggtaaaactt   5820

gttaccaaca catgtgaacc attgctacat tgtaggttgt gatcattttg ccccactgaa   5880

gcccatgtat ctgaccttac gtgccttttg aactaggaga atcgggctaa tttattaatg   5940

atgataatta taatgtatct gtacagcact ttttacattt gcgaagtgct ttccaatcca   6000

tgttagttac tagttattac agctgtaagg ataaaacacg tcatgtggat tcattttgaa   6060

ttggtgctat tggtatttcc tctgttattg ctaataaatg aaaatggtgg tatgaaa      6117


<210>  2219
<211>  1007
<212>  PRT
<213>  Homo sapiens

<400>  2219


Met Glu Gln Ala Gly Thr Arg Pro Ala Ala Thr Glu His Pro Arg Leu 
1               5                   10                  15      


Arg Arg Pro Met Pro Trp Leu Leu Leu Leu Pro Leu Leu Leu Leu Leu 
            20                  25                  30          


Leu Leu Leu Leu Pro Gly Pro Ala Ala Ser Gln Leu Arg Tyr Ser Val 
        35                  40                  45              


Pro Glu Glu Gln Ala Pro Gly Ala Leu Val Gly Asn Val Ala Arg Ala 
    50                  55                  60                  


Leu Gly Leu Glu Leu Arg Arg Leu Gly Pro Gly Cys Leu Arg Ile Asn 
65                  70                  75                  80  


His Leu Gly Ala Pro Ser Pro Arg Tyr Leu Glu Leu Asp Leu Thr Ser 
                85                  90                  95      


Gly Ala Leu Phe Val Asn Glu Arg Ile Asp Arg Glu Ala Leu Cys Glu 
            100                 105                 110         


Gln Arg Pro Arg Cys Leu Leu Ser Leu Glu Val Leu Ala His Asn Pro 
        115                 120                 125             


Val Ala Val Ser Ala Val Glu Val Glu Ile Leu Asp Ile Asn Asp Asn 
    130                 135                 140                 


Ser Pro Arg Phe Pro Arg Pro Asn Tyr Gln Leu Gln Val Ser Glu Ser 
145                 150                 155                 160 


Val Ala Pro Gly Ala Arg Phe His Ile Glu Ser Ala Gln Asp Pro Asp 
                165                 170                 175     


Val Gly Ala Asn Ser Val Gln Thr Tyr Glu Leu Ser Pro Ser Glu His 
            180                 185                 190         


Phe Glu Leu Asp Leu Lys Pro Leu Gln Glu Asn Ser Lys Val Leu Glu 
        195                 200                 205             


Leu Val Leu Arg Lys Gly Leu Asp Arg Glu Gln Ala Ala Leu His His 
    210                 215                 220                 


Leu Val Leu Thr Ala Val Asp Gly Gly Ile Pro Ala Arg Ser Gly Thr 
225                 230                 235                 240 


Ala Gln Ile Ser Val Arg Val Leu Asp Thr Asn Asp Asn Ser Pro Ala 
                245                 250                 255     


Phe Asp Gln Ser Thr Tyr Arg Val Gln Leu Arg Glu Asp Ser Pro Pro 
            260                 265                 270         


Gly Thr Leu Val Val Lys Leu Asn Ala Ser Asp Pro Asp Glu Gly Ser 
        275                 280                 285             


Asn Gly Glu Leu Arg Tyr Ser Leu Ser Ser Tyr Thr Ser Asp Arg Glu 
    290                 295                 300                 


Arg Gln Leu Phe Ser Ile Asp Ala Ser Thr Gly Glu Val Arg Val Ile 
305                 310                 315                 320 


Gly Gly Leu Asp Tyr Glu Glu Ala Ser Ser Tyr Gln Ile Tyr Val Gln 
                325                 330                 335     


Ala Thr Asp Arg Gly Pro Val Pro Met Ala Gly His Cys Lys Val Leu 
            340                 345                 350         


Val Asp Ile Val Asp Val Asn Asp Asn Ala Pro Glu Val Val Leu Thr 
        355                 360                 365             


Asp Leu Tyr Ser Pro Val Pro Glu Asn Ala Thr Pro Asn Thr Ile Val 
    370                 375                 380                 


Ala Val Leu Ser Val Asn Asp Gln Asp Ser Gly Pro Asn Arg Lys Val 
385                 390                 395                 400 


Ser Leu Gly Leu Glu Ala Thr Leu Pro Phe Arg Leu Asn Gly Phe Gly 
                405                 410                 415     


Asn Ser Tyr Thr Leu Val Val Ser Gly Pro Leu Asp Arg Glu Arg Val 
            420                 425                 430         


Ala Val Tyr Asn Ile Thr Val Thr Ala Thr Asp Gly Gly Ile Pro Gln 
        435                 440                 445             


Leu Thr Ser Leu Arg Thr Leu Lys Val Glu Ile Ser Asp Ile Asn Asp 
    450                 455                 460                 


Asn Pro Pro Ser Phe Leu Glu Asp Ser Tyr Ser Ile Tyr Ile Gln Glu 
465                 470                 475                 480 


Asn Asn Leu Pro Gly Val Leu Leu Cys Thr Val Gln Ala Thr Asp Pro 
                485                 490                 495     


Asp Glu Lys Glu Asn Ala Glu Val Thr Tyr Ser Leu Leu Glu Arg Glu 
            500                 505                 510         


Ile Gln Gly Leu Pro Val Thr Ser Tyr Val Ser Ile Asn Ser Ala Ser 
        515                 520                 525             


Gly Ser Leu Tyr Ala Val Asn Ser Phe Asp Tyr Glu Lys Phe Arg Glu 
    530                 535                 540                 


Phe Phe Val Thr Val Glu Ala Gln Asp Lys Gly Ser Pro Pro Leu Ser 
545                 550                 555                 560 


Ser Thr Val Thr Ala Asn Val Tyr Val Val Asp Met Asn Asp His Ala 
                565                 570                 575     


Pro His Ile Leu Tyr Pro Thr Ser Thr Asn Ser Ser Ala Ala Phe Glu 
            580                 585                 590         


Met Val Pro Arg Thr Ala Pro Ala Gly Tyr Leu Val Thr Lys Val Ile 
        595                 600                 605             


Ala Met Asp Ser Asp Ser Gly Gln Asn Ala Trp Leu Phe Tyr His Leu 
    610                 615                 620                 


Ala Gln Thr Ser Asp Leu Asp Leu Phe Lys Val Glu Leu His Thr Gly 
625                 630                 635                 640 


Glu Ile Arg Thr Thr Arg Lys Met Gly Asp Glu Ser Gly Ser Thr Phe 
                645                 650                 655     


Asn Leu Thr Val Val Val Arg Asp Asn Gly Glu Pro Ser Leu Ser Ala 
            660                 665                 670         


Ser Val Ala Ile Thr Val Ala Val Val Asp Arg Val Ser Lys Ile Leu 
        675                 680                 685             


Pro Asp Thr Gln Arg His Val Lys Ser Pro Arg Thr Tyr Ser Glu Ile 
    690                 695                 700                 


Thr Leu Tyr Leu Ile Ile Ala Leu Ser Thr Val Ser Phe Ile Phe Leu 
705                 710                 715                 720 


Leu Thr Ile Ile Ile Leu Ser Ile Ile Lys Cys Tyr Arg Tyr Thr Ala 
                725                 730                 735     


Tyr Gly Thr Ala Cys Cys Gly Gly Phe Cys Gly Val Arg Glu Arg Ser 
            740                 745                 750         


Pro Ala Glu Leu Tyr Lys Gln Ala Asn Asn Asn Ile Asp Ala Arg Ile 
        755                 760                 765             


Pro His Gly Leu Lys Val Gln Pro His Phe Ile Glu Val Arg Gly Asn 
    770                 775                 780                 


Gly Ser Leu Thr Lys Thr Tyr Cys Tyr Lys Ala Cys Leu Thr Ala Gly 
785                 790                 795                 800 


Ser Gly Ser Asp Thr Phe Met Phe Tyr Asn Thr Gly Ala Gln Thr Gly 
                805                 810                 815     


Pro Gly Pro Ser Gly Ala Gln Ala Ala Val Thr Asp Ser Arg Asn Leu 
            820                 825                 830         


Thr Gly Gln Ser Gly Gln Asn Ala Gly Asn Leu Ile Ile Leu Lys Asn 
        835                 840                 845             


Glu Ala Val Ser Gln Asn Glu Pro Arg Gln Pro Asn Pro Asp Trp Arg 
    850                 855                 860                 


Tyr Ser Ala Ser Leu Arg Ala Gly Met His Ser Ser Val His Leu Glu 
865                 870                 875                 880 


Glu Ala Gly Ile Leu Arg Ala Gly Pro Gly Gly Pro Asp Gln Gln Trp 
                885                 890                 895     


Pro Thr Val Ser Ser Ala Thr Pro Glu Pro Glu Ala Gly Glu Val Ser 
            900                 905                 910         


Pro Pro Val Gly Ala Gly Val Asn Ser Asn Ser Trp Thr Phe Lys Tyr 
        915                 920                 925             


Gly Pro Gly Asn Pro Lys Gln Ser Gly Pro Gly Glu Leu Pro Asp Lys 
    930                 935                 940                 


Phe Ile Ile Pro Gly Ser Pro Ala Ile Ile Ser Ile Arg Gln Glu Pro 
945                 950                 955                 960 


Thr Asn Ser Gln Ile Asp Lys Ser Asp Phe Ile Thr Phe Gly Lys Lys 
                965                 970                 975     


Glu Glu Thr Lys Lys Lys Lys Lys Lys Lys Lys Gly Asn Lys Thr Gln 
            980                 985                 990         


Glu Lys Lys Glu Lys Gly Asn Ser  Thr Thr Asp Asn Ser  Asp Gln 
        995                 1000                 1005         

<210>  2220
<211>  2172
<212>  DNA
<213>  Homo sapiens

<400>  2220
agttcaagca tgagcagaat gtgttagctg cagccctggc ttcatagttg taagcaattt     60

ctgagggtgg aagaagagat gggaaagaat ttatgatcta accgttatct gggtctgtgt    120

gtttattcag ctctgtgcac ctagaggagg ctggcattct acgggctggt ccaggagggc    180

ctgatcagca gtggccaaca gtatccagtg caacaccaga accagaggca ggagaagtgt    240

cccctccagt cggtgcgggt gtcaacagca acagctggac ctttaaatac ggaccaggca    300

accccaaaca atccggtccc ggtgagttgc ccgacaaatt cattatccca ggatctcctg    360

caatcatctc catccggcag gagcctacta acagccaaat tgacaaaagt gacttcataa    420

ccttcggcaa aaaggaggag accaagaaaa agaagaaaaa gaagaagggt aacaagaccc    480

aggagaaaaa agagaaaggg aacagcacga ctgacaacag tgaccagtga ggtcctcaaa    540

tggaaacaag ccacttagcc agtttttgta ataatggcaa atctctccca tgtagcaatt    600

ccctgctcct ttttcctatc tacatgagcc ctcttagaga cctcagaaat ctgcagaaag    660

ttccctgtgt ctgtctagaa cgcatttaac aggttttgtc gtaaaagctt tactaagtct    720

ggtgttaact ctttctctcc actctggctt gttttcagaa cctaaaaagc agacccaagt    780

ttcctttctc ctccgccgca aaggagaggc ttcccagccc cgccagtgag aggttggact    840

ctctgccctg tgctccgggg atcctgtctt gatgacactt gcagggcagg ctgaaaagtt    900

ttgagattga gcagcttggg agtttgtggc cactgggtat gtgtggctac cgcgggtatg    960

cgagtgccag atattggctg agacgagcca gcttagacta attggtacaa ggaaggcaag   1020

aaaacaaaga caaataaaca gcggaagtta tcagtatgga ggggaagtgt aaacttaaag   1080

ggaccagact ttctaaatct tacaactcaa gaggtggcag ccaccctcta ggagacaaaa   1140

ctacccccac tgacaaggct ttaggagacc ctaaagtctg ttggctgtga cgtcattata   1200

cctaaaatct gcatcatacc tgcaagccaa cagttcagtg ttttaacaga gaaccaccct   1260

gggaaacaga agcagatctg atgtgtttcc tatacatgtc ctgtgctcac tttattaaaa   1320

attcttttgc acacaatgtt tatgaaaagg ccagatcctt ttccaatact tatgcaaaag   1380

caaaagaaaa ccccgacacc tcacctttcg ctgtttgttg tttcatagat ttatttaaaa   1440

aaagagaaag tctatagcta taaatcttta aagagaaata tgaatacaat tcccctaaac   1500

tctcctcaaa agagaattca gtctacagcc atttaaatga tcattgctgc tacagaagtg   1560

ctttaagaga attgcctgaa acatctgtat tatatcggcc acctgccaat cacagcttta   1620

ctctttcagg tcactctggg gctgcctctt gcatgtatta ctaaataaaa tgatctctct   1680

ttctctctct ctctctcttt tctaagaaac aattatgtgc actttgatac acaaccttct   1740

ctaaccaact atatatcaag acccaaaaat tgaagaaaaa tattgttttc tcatacagtg   1800

agcagatttt tcaatctact aattctgtga cttgtcttgg tgtgctagcc tacaccttct   1860

ctttggttta gttttccttt tctataacac tctgaattgc taatcttact aacacctatg   1920

atgttacctg aaatcaatct cccatatgta tgctgtatgc tatgctaaga ctcctgaaat   1980

atacttactc tgtgcttgtg tatgtgaatg ttaatgcaac tattacctag agtgaacttt   2040

aagctttatt gttgaatgta attccattat atttcctttt gtacacctgt gaaaaagtgg   2100

agtagtgttt ttttaaccat tgttaatcag cttttgtgta tgaaagacac agtaaaattt   2160

ctttcttaaa tc                                                       2172


<210>  2221
<211>  58
<212>  PRT
<213>  Homo sapiens

<400>  2221


Met Cys Phe Leu Tyr Met Ser Cys Ala His Phe Ile Lys Asn Ser Phe 
1               5                   10                  15      


Ala His Asn Val Tyr Glu Lys Ala Arg Ser Phe Ser Asn Thr Tyr Ala 
            20                  25                  30          


Lys Ala Lys Glu Asn Pro Asp Thr Ser Pro Phe Ala Val Cys Cys Phe 
        35                  40                  45              


Ile Asp Leu Phe Lys Lys Arg Glu Ser Leu 
    50                  55              

<210>  2222
<211>  2940
<212>  DNA
<213>  Homo sapiens

<400>  2222
agttcaagca tgagcagaat gtgttagctg cagccctggc ttcatagttg taagcaattt     60

ctgagggtgg aagaagagat gggaaagaat ttatgatcta accgttatct gggtctgtgt    120

gtttattcag ctctgtgcac ctagaggagg ctggcattct acgggctggt ccaggagggc    180

ctgatcagca gtggccaaca gtatccagtg caacaccaga accagaggca ggagaagtgt    240

cccctccagt cggtgcgggt gtcaacagca acagctggac ctttaaatac ggaccaggca    300

accccaaaca atccggtccc ggtgagttgc ccgacaaatt cattatccca ggatctcctg    360

caatcatctc catccggcag gagcctacta acagccaaat tgacaaaagt gacttcataa    420

ccttcggcaa aaaggaggag accaagaaaa agaagaaaaa gaagaagggt aacaagaccc    480

aggagaaaaa agagaaaggg aacagcacga ctgacaacag tgaccagtga ggtcctcaaa    540

tggaaacaag ccacttagcc agtttttgta ataatggcaa atctctccca tgtagcaatt    600

ccctgctcct ttttcctatc tacatgagcc ctcttagaga cctcagaaat ctgcagaaag    660

ttccctgtgt ctgtctagaa cgcatttaac aggttttgtc gtaaaagctt tactaagtct    720

ggtgttaact ctttctctcc actctggctt gttttcagaa cctaaaaagc agacccaagt    780

ttcctttctc ctccgccgca aaggagaggc ttcccagccc cgccagtgag aggttggact    840

ctctgccctg tgctccgggg atcctgtctt gatgacactt gcagggcagg ctgaaaagtt    900

ttgagattga gcagcttggg agtttgtggc cactgggtat gtgtggctac cgcgggtatg    960

cgagtgccag atattggctg agacgagcca gcttagacta attggtacaa ggaaggcaag   1020

aaaacaaaga caaataaaca gcggaagtta tcagtatgga ggggaagtgt aaacttaaag   1080

ggaccagact ttctaaatct tacaactcaa gaggtggcag ccaccctcta ggagacaaaa   1140

ctacccccac tgacaaggct ttaggagacc ctaaagtctg ttggctgtga cgtcattata   1200

cctaaaatct gcatcatacc tgcaagccaa cagttcagtg ttttaacaga gaaccaccct   1260

gggaaacaga agcagatctg atgtgtttcc tatacatgtc ctgtgctcac tttattaaaa   1320

attcttttgc acacaatgtt tatgaaaagg ccagatcctt ttccaatact tatgcaaaag   1380

caaaagaaaa ccccgacacc tcacctttcg ctgtttgttg tttcatagat ttatttaaaa   1440

aaagagaaag tctatagcta taaatcttta aagagaaata tgaatacaat tcccctaaac   1500

tctcctcaaa agagaattca gtctacagcc atttaaatga tcattgctgc tacagaagtg   1560

ctttaagaga attgcctgaa acatctgtat tatatcggcc acctgccaat cacagcttta   1620

ctctttcagg tcactctggg gctgcctctt gcatgtatta ctaaataaaa tgatctctct   1680

ttctctctct ctctctcttt tctaagaaac aattatgtgc actttgatac acaaccttct   1740

ctaaccaact atatatcaag acccaaaaat tgaagaaaaa tattgttttc tcatacagtg   1800

agcagatttt tcaatctact aattctgtga cttgtcttgg tgtgctagcc tacaccttct   1860

ctttggttta gttttccttt tctataacac tctgaattgc taatcttact aacacctatg   1920

atgttacctg aaatcaatct cccatatgta tgctgtatgc tatgctaaga ctcctgaaat   1980

atacttactc tgtgcttgtg tatgtgaatg ttaatgcaac tattacctag agtgaacttt   2040

aagctttatt gttgaatgta attccattat atttcctttt gtacacctgt gaaaaagtgg   2100

agtagtgttt ttttaaccat tgttaatcag cttttgtgta tgaaagacac agtaaaattt   2160

ctttcttaaa tcaagatact ggtgattcaa ggaattttat ttatggtcca gccaagagcc   2220

atctcgtgcc aagacttctg ctggcaaggg aatggataaa gctgttttgt tctagtaaca   2280

attttggaat gaatactgac aatattccat gagggtgtgc aagcacaaat tttaccaatc   2340

tgacctcttt gaagttgcag aatgctttga aattctaatg gtatctgaaa tatcagctca   2400

tagaaagtaa caaaatttgc tgtcacctta aataagacat tttaattttg ttataatgta   2460

caatttagaa gtttgattaa ttatattatc tatttaggca ttaatataaa agaggtagga   2520

gtctgttatt taaaaaaagc attaaattta aaaaaaaact gtcttgtcta cttttagctt   2580

cattctccca tattttgaag ggtgtgtaac ttcagctctg caggattgca tggggtaaaa   2640

cttgttacca acacatgtga accattgcta cattgtaggt tgtgatcatt ttgccccact   2700

gaagcccatg tatctgacct tacgtgcctt ttgaactagg agaatcgggc taatttatta   2760

atgatgataa ttataatgta tctgtacagc actttttaca tttgcgaagt gctttccaat   2820

ccatgttagt tactagttat tacagctgta aggataaaac acgtcatgtg gattcatttt   2880

gaattggtgc tattggtatt tcctctgtta ttgctaataa atgaaaatgg tggtatgaaa   2940


<210>  2223
<211>  58
<212>  PRT
<213>  Homo sapiens

<400>  2223


Met Cys Phe Leu Tyr Met Ser Cys Ala His Phe Ile Lys Asn Ser Phe 
1               5                   10                  15      


Ala His Asn Val Tyr Glu Lys Ala Arg Ser Phe Ser Asn Thr Tyr Ala 
            20                  25                  30          


Lys Ala Lys Glu Asn Pro Asp Thr Ser Pro Phe Ala Val Cys Cys Phe 
        35                  40                  45              


Ile Asp Leu Phe Lys Lys Arg Glu Ser Leu 
    50                  55              

<210>  2224
<211>  2029
<212>  DNA
<213>  Homo sapiens

<400>  2224
agaatagaac aacactgttc tcttaggctg cagtttcctt caagccccac gatggagaga     60

agcaggctaa tgcaggaacc agaggcagga gaagtgtccc ctccagtcgg tgcgggtgtc    120

aacagcaaca gctggacctt taaatacgga ccaggcaacc ccaaacaatc cggtcccggt    180

gagttgcccg acaaattcat tatcccagga tctcctgcaa tcatctccat ccggcaggag    240

cctactaaca gccaaattga caaaagtgac ttcataacct tcggcaaaaa ggaggagacc    300

aagaaaaaga agaaaaagaa gaagggtaac aagacccagg agaaaaaaga gaaagggaac    360

agcacgactg acaacagtga ccagtgaggt cctcaaatgg aaacaagcca cttagccagt    420

ttttgtaata atggcaaatc tctcccatgt agcaattccc tgctcctttt tcctatctac    480

atgagccctc ttagagacct cagaaatctg cagaaagttc cctgtgtctg tctagaacgc    540

atttaacagg ttttgtcgta aaagctttac taagtctggt gttaactctt tctctccact    600

ctggcttgtt ttcagaacct aaaaagcaga cccaagtttc ctttctcctc cgccgcaaag    660

gagaggcttc ccagccccgc cagtgagagg ttggactctc tgccctgtgc tccggggatc    720

ctgtcttgat gacacttgca gggcaggctg aaaagttttg agattgagca gcttgggagt    780

ttgtggccac tgggtatgtg tggctaccgc gggtatgcga gtgccagata ttggctgaga    840

cgagccagct tagactaatt ggtacaagga aggcaagaaa acaaagacaa ataaacagcg    900

gaagttatca gtatggaggg gaagtgtaaa cttaaaggga ccagactttc taaatcttac    960

aactcaagag gtggcagcca ccctctagga gacaaaacta cccccactga caaggcttta   1020

ggagacccta aagtctgttg gctgtgacgt cattatacct aaaatctgca tcatacctgc   1080

aagccaacag ttcagtgttt taacagagaa ccaccctggg aaacagaagc agatctgatg   1140

tgtttcctat acatgtcctg tgctcacttt attaaaaatt cttttgcaca caatgtttat   1200

gaaaaggcca gatccttttc caatacttat gcaaaagcaa aagaaaaccc cgacacctca   1260

cctttcgctg tttgttgttt catagattta tttaaaaaaa gagaaagtct atagctataa   1320

atctttaaag agaaatatga atacaattcc cctaaactct cctcaaaaga gaattcagtc   1380

tacagccatt taaatgatca ttgctgctac agaagtgctt taagagaatt gcctgaaaca   1440

tctgtattat atcggccacc tgccaatcac agctttactc tttcaggtca ctctggggct   1500

gcctcttgca tgtattacta aataaaatga tctctctttc tctctctctc tctcttttct   1560

aagaaacaat tatgtgcact ttgatacaca accttctcta accaactata tatcaagacc   1620

caaaaattga agaaaaatat tgttttctca tacagtgagc agatttttca atctactaat   1680

tctgtgactt gtcttggtgt gctagcctac accttctctt tggtttagtt ttccttttct   1740

ataacactct gaattgctaa tcttactaac acctatgatg ttacctgaaa tcaatctccc   1800

atatgtatgc tgtatgctat gctaagactc ctgaaatata cttactctgt gcttgtgtat   1860

gtgaatgtta atgcaactat tacctagagt gaactttaag ctttattgtt gaatgtaatt   1920

ccattatatt tccttttgta cacctgtgaa aaagtggagt agtgtttttt taaccattgt   1980

taatcagctt ttgtgtatga aagacacagt aaaatttctt tcttaaatc               2029


<210>  2225
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  2225


Met Glu Arg Ser Arg Leu Met Gln Glu Pro Glu Ala Gly Glu Val Ser 
1               5                   10                  15      


Pro Pro Val Gly Ala Gly Val Asn Ser Asn Ser Trp Thr Phe Lys Tyr 
            20                  25                  30          


Gly Pro Gly Asn Pro Lys Gln Ser Gly Pro Gly Glu Leu Pro Asp Lys 
        35                  40                  45              


Phe Ile Ile Pro Gly Ser Pro Ala Ile Ile Ser Ile Arg Gln Glu Pro 
    50                  55                  60                  


Thr Asn Ser Gln Ile Asp Lys Ser Asp Phe Ile Thr Phe Gly Lys Lys 
65                  70                  75                  80  


Glu Glu Thr Lys Lys Lys Lys Lys Lys Lys Lys Gly Asn Lys Thr Gln 
                85                  90                  95      


Glu Lys Lys Glu Lys Gly Asn Ser Thr Thr Asp Asn Ser Asp Gln 
            100                 105                 110     

<210>  2226
<211>  2797
<212>  DNA
<213>  Homo sapiens

<400>  2226
agaatagaac aacactgttc tcttaggctg cagtttcctt caagccccac gatggagaga     60

agcaggctaa tgcaggaacc agaggcagga gaagtgtccc ctccagtcgg tgcgggtgtc    120

aacagcaaca gctggacctt taaatacgga ccaggcaacc ccaaacaatc cggtcccggt    180

gagttgcccg acaaattcat tatcccagga tctcctgcaa tcatctccat ccggcaggag    240

cctactaaca gccaaattga caaaagtgac ttcataacct tcggcaaaaa ggaggagacc    300

aagaaaaaga agaaaaagaa gaagggtaac aagacccagg agaaaaaaga gaaagggaac    360

agcacgactg acaacagtga ccagtgaggt cctcaaatgg aaacaagcca cttagccagt    420

ttttgtaata atggcaaatc tctcccatgt agcaattccc tgctcctttt tcctatctac    480

atgagccctc ttagagacct cagaaatctg cagaaagttc cctgtgtctg tctagaacgc    540

atttaacagg ttttgtcgta aaagctttac taagtctggt gttaactctt tctctccact    600

ctggcttgtt ttcagaacct aaaaagcaga cccaagtttc ctttctcctc cgccgcaaag    660

gagaggcttc ccagccccgc cagtgagagg ttggactctc tgccctgtgc tccggggatc    720

ctgtcttgat gacacttgca gggcaggctg aaaagttttg agattgagca gcttgggagt    780

ttgtggccac tgggtatgtg tggctaccgc gggtatgcga gtgccagata ttggctgaga    840

cgagccagct tagactaatt ggtacaagga aggcaagaaa acaaagacaa ataaacagcg    900

gaagttatca gtatggaggg gaagtgtaaa cttaaaggga ccagactttc taaatcttac    960

aactcaagag gtggcagcca ccctctagga gacaaaacta cccccactga caaggcttta   1020

ggagacccta aagtctgttg gctgtgacgt cattatacct aaaatctgca tcatacctgc   1080

aagccaacag ttcagtgttt taacagagaa ccaccctggg aaacagaagc agatctgatg   1140

tgtttcctat acatgtcctg tgctcacttt attaaaaatt cttttgcaca caatgtttat   1200

gaaaaggcca gatccttttc caatacttat gcaaaagcaa aagaaaaccc cgacacctca   1260

cctttcgctg tttgttgttt catagattta tttaaaaaaa gagaaagtct atagctataa   1320

atctttaaag agaaatatga atacaattcc cctaaactct cctcaaaaga gaattcagtc   1380

tacagccatt taaatgatca ttgctgctac agaagtgctt taagagaatt gcctgaaaca   1440

tctgtattat atcggccacc tgccaatcac agctttactc tttcaggtca ctctggggct   1500

gcctcttgca tgtattacta aataaaatga tctctctttc tctctctctc tctcttttct   1560

aagaaacaat tatgtgcact ttgatacaca accttctcta accaactata tatcaagacc   1620

caaaaattga agaaaaatat tgttttctca tacagtgagc agatttttca atctactaat   1680

tctgtgactt gtcttggtgt gctagcctac accttctctt tggtttagtt ttccttttct   1740

ataacactct gaattgctaa tcttactaac acctatgatg ttacctgaaa tcaatctccc   1800

atatgtatgc tgtatgctat gctaagactc ctgaaatata cttactctgt gcttgtgtat   1860

gtgaatgtta atgcaactat tacctagagt gaactttaag ctttattgtt gaatgtaatt   1920

ccattatatt tccttttgta cacctgtgaa aaagtggagt agtgtttttt taaccattgt   1980

taatcagctt ttgtgtatga aagacacagt aaaatttctt tcttaaatca agatactggt   2040

gattcaagga attttattta tggtccagcc aagagccatc tcgtgccaag acttctgctg   2100

gcaagggaat ggataaagct gttttgttct agtaacaatt ttggaatgaa tactgacaat   2160

attccatgag ggtgtgcaag cacaaatttt accaatctga cctctttgaa gttgcagaat   2220

gctttgaaat tctaatggta tctgaaatat cagctcatag aaagtaacaa aatttgctgt   2280

caccttaaat aagacatttt aattttgtta taatgtacaa tttagaagtt tgattaatta   2340

tattatctat ttaggcatta atataaaaga ggtaggagtc tgttatttaa aaaaagcatt   2400

aaatttaaaa aaaaactgtc ttgtctactt ttagcttcat tctcccatat tttgaagggt   2460

gtgtaacttc agctctgcag gattgcatgg ggtaaaactt gttaccaaca catgtgaacc   2520

attgctacat tgtaggttgt gatcattttg ccccactgaa gcccatgtat ctgaccttac   2580

gtgccttttg aactaggaga atcgggctaa tttattaatg atgataatta taatgtatct   2640

gtacagcact ttttacattt gcgaagtgct ttccaatcca tgttagttac tagttattac   2700

agctgtaagg ataaaacacg tcatgtggat tcattttgaa ttggtgctat tggtatttcc   2760

tctgttattg ctaataaatg aaaatggtgg tatgaaa                            2797


<210>  2227
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  2227


Met Glu Arg Ser Arg Leu Met Gln Glu Pro Glu Ala Gly Glu Val Ser 
1               5                   10                  15      


Pro Pro Val Gly Ala Gly Val Asn Ser Asn Ser Trp Thr Phe Lys Tyr 
            20                  25                  30          


Gly Pro Gly Asn Pro Lys Gln Ser Gly Pro Gly Glu Leu Pro Asp Lys 
        35                  40                  45              


Phe Ile Ile Pro Gly Ser Pro Ala Ile Ile Ser Ile Arg Gln Glu Pro 
    50                  55                  60                  


Thr Asn Ser Gln Ile Asp Lys Ser Asp Phe Ile Thr Phe Gly Lys Lys 
65                  70                  75                  80  


Glu Glu Thr Lys Lys Lys Lys Lys Lys Lys Lys Gly Asn Lys Thr Gln 
                85                  90                  95      


Glu Lys Lys Glu Lys Gly Asn Ser Thr Thr Asp Asn Ser Asp Gln 
            100                 105                 110     

<210>  2228
<211>  712
<212>  DNA
<213>  Homo sapiens

<400>  2228
agtcttgctc tgtcacctac actggaattc agtggcacag tctcagctca gctcactgca     60

acctccacct cccgggttca agtgattctc atacctcagc ctcctgagta gctgggatta    120

caggaaaaaa agtccttggg aattgagaag ccaatgagat tagtcgttca agctgaagtc    180

attctatctg ctagctgtct ggagccactg aagctgtggg cgaacagcaa caagtttaag    240

ctacatctgc acactctgcg gtccatccag agaccaagaa agaagcacaa ggatcctgca    300

gagtcttccg aagcccaagc caaatatatg aggcagggag ctagagaatg tggaggaagt    360

ggtcagtagg aaaaggaatg ggaacagaca ttctccttca gaaacttgag gtccagtccc    420

tgaactttag ctggccccaa aacttgagca agctctaaaa agcagaacat ctcccactta    480

acagtttatt ctgagaactg gccaaccaca ggagggaaaa tcatatctcc agttaaagtg    540

ccctgatcat gccatctgct catcctaccc cctttgccct gctcccacac aaagttcctg    600

ctagccctgt ttacgtcttc ttttttaaac tcttttttta aaatttgatt tttagacatt    660

tgaagatttc catggtcaga gggtctgtaa tagtcttttt tgaataaagc tg            712


<210>  2229
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  2229


Met Trp Arg Lys Trp Ser Val Gly Lys Gly Met Gly Thr Asp Ile Leu 
1               5                   10                  15      


Leu Gln Lys Leu Glu Val Gln Ser Leu Asn Phe Ser Trp Pro Gln Asn 
            20                  25                  30          


Leu Ser Lys Leu 
        35      

<210>  2230
<211>  2828
<212>  DNA
<213>  Homo sapiens

<400>  2230
tctcattggc ttctcaattc ccaaggactt tttttcctga aagggaatta acaggtgagt     60

ctgttgttgc tttggcaaca aactttcaac ctctacctaa ctctccggaa tgagaacata    120

tctattaata cattcgctag actggggagt tgagtcgctc aatgcaaatt ttctttcaag    180

tgcaaaacag cttaatgggc tcggctagcc tttggtggtg ctgcagttag aggctagtga    240

agcggagagc agctgttgca gtaacctgtt gcagaaaagt gaaagtatat ccgcaacagt    300

tggctctgat tgcagagagc gcgcttgtga gaactgatgg cgggtacgcg cagaaaatct    360

ttgcaaaaca ggcaagtggg atctcttctc atttttctgt gcatatctgt gggggatgcg    420

acaactatcc gctattcagt ggcagaggaa atggagagcg gctcgtttgt ggccaacgta    480

gctaaggacc taggactgga ggtagggaag ctggctgcgc gcggggcgcg gctggtttcc    540

gagggcaaca aaatgcattt ccggctccac cgcaagacgg gagatttgtt tgtgaaggag    600

aaactggatc gggagtcact ttgtggcaaa gccgaccctt gtgttctgca ctttgaagta    660

gtcctggtgg agccgctgca gtccttccgg gccgaggtca gggtatttga tatcaatgac    720

aatgccccag ttttcctaaa caaggagccg cttttaaaga ttccggagag cacccctttg    780

ggttcacgtt ttcctctgca gagcgcccag gatctggacg tgggccttaa cggtctccag    840

aactacaccc tgagtgccaa tgggtatttc cacctgcaca cccgcttctg cagccacggg    900

cctaaatatg ctgagctggt gctgaacaaa cccctggacc gagaggagca gcctgaagtc    960

aacttgacaa ttacggcggt ggacggcggg tccccgccta agtctggcac agctcacatc   1020

cacgtggtgg ttctggatgt caacgaccac gtgccccagt tctcgcgact ggtgtacaga   1080

gcccaggtat cagagaacag ccccaatggc tctttggtgg ccacggtgac tgccgtggac   1140

ctagacgagg gcaccaacaa agcgataact tactctttag ctcaaaaccc agaagcaatt   1200

ctcaagacgt ttcagattga ccctcaaaat ggagaagttc gactaagagg acccctcgat   1260

tttgaagcca ttgaaacata cgacattgac attcaagcta cagatggtgg aggcctctct   1320

gcccacagca aagtcctggt agaagtggtg gatgtgaatg acaatcctcc cgaagtgatg   1380

gtctcctctg tgtccagccc actccctgaa gactcaccac cacagacagt agtagccctt   1440

ttcactatca gagaccggga cattcgagtg ggaggaaaag tcacctgctt cctcagagaa   1500

gaccttccct ttgtaatcaa acctacattt gggaattctt actcactggt cactgacaga   1560

agcttggatc gggaggaggt ctcaggctat aatatcacca ttgttgccat ggatactgga   1620

ccacctagct tgtctgccga gactatgata gaggtgctaa tatccgacgt taatgacaat   1680

cctccaatat ttcgggaaga ttcctatatc ttgactgttc gagaaaacaa cagtcctgcg   1740

gtttttattg gcaaagtcca tgctgaggat cttgatttgg gtgagaatgc ccaaataaca   1800

tattctctgt tgcctccaaa aaacggagat ctttcagtct ttgcttacat atccataaat   1860

tcaggcaatg ggaagctcta cgcgctgaga accatggatt atgaggccat tcaagatttt   1920

caatttgtgg taaaggcaac tgatgggggc ttcctgtcac tgagtagcca agttactgtc   1980

agagtggttg tcctagatga caatgacaat cgtccaatga tcttataccc actgcagaac   2040

ggcaccttgc cctgcaatga cctggtgccc aggtctgcag aggcaggcta cctagtgacc   2100

aaagtggtgg ctgtggatgg tgactcaggt cagaattctt ggctttcata tcatctactt   2160

aaggccactg accttgggtt attttctgtt caaagacaaa atggagaaat ccatacatta   2220

aggcagatat ctgagagaga ccccatgatg cagaaattga tcattcttgt tcaggatcac   2280

ggccaaccag ctctttccac tactgtctca ctcaacatcc tgctggtaga tggcttttca   2340

gagccctacc tgcagttcca ggatccaacc aagcattcta gaaaggtaaa tccatccact   2400

aaatatttgg tcatttctct ggtcatcctt tcctttctct ttctcctctc tgtcatagtg   2460

atcttcatta tacatgtcta ccaaaagatt aaatatagag aaaagttcac aattcaagag   2520

catttctatg atgactgtaa tttctctaac aacctggtac aaggacaagg caatggatcc   2580

ttatctcggc cttgtccata tgaaatgtgt tcagccactg gcactggtaa tagtgagttt   2640

cgctttctta agcgttttat gcccaacttc cctttccctc atgccactgg ggagataaaa   2700

atggaggctg gctccagttt gcccccaaat tctgatagga ataagtctca gagattagag   2760

ggccatgacc aggtatctga tgactatatg tagctcctat ttacaggctc agtgagagaa   2820

gagaagca                                                            2828


<210>  2231
<211>  818
<212>  PRT
<213>  Homo sapiens

<400>  2231


Met Ala Gly Thr Arg Arg Lys Ser Leu Gln Asn Arg Gln Val Gly Ser 
1               5                   10                  15      


Leu Leu Ile Phe Leu Cys Ile Ser Val Gly Asp Ala Thr Thr Ile Arg 
            20                  25                  30          


Tyr Ser Val Ala Glu Glu Met Glu Ser Gly Ser Phe Val Ala Asn Val 
        35                  40                  45              


Ala Lys Asp Leu Gly Leu Glu Val Gly Lys Leu Ala Ala Arg Gly Ala 
    50                  55                  60                  


Arg Leu Val Ser Glu Gly Asn Lys Met His Phe Arg Leu His Arg Lys 
65                  70                  75                  80  


Thr Gly Asp Leu Phe Val Lys Glu Lys Leu Asp Arg Glu Ser Leu Cys 
                85                  90                  95      


Gly Lys Ala Asp Pro Cys Val Leu His Phe Glu Val Val Leu Val Glu 
            100                 105                 110         


Pro Leu Gln Ser Phe Arg Ala Glu Val Arg Val Phe Asp Ile Asn Asp 
        115                 120                 125             


Asn Ala Pro Val Phe Leu Asn Lys Glu Pro Leu Leu Lys Ile Pro Glu 
    130                 135                 140                 


Ser Thr Pro Leu Gly Ser Arg Phe Pro Leu Gln Ser Ala Gln Asp Leu 
145                 150                 155                 160 


Asp Val Gly Leu Asn Gly Leu Gln Asn Tyr Thr Leu Ser Ala Asn Gly 
                165                 170                 175     


Tyr Phe His Leu His Thr Arg Phe Cys Ser His Gly Pro Lys Tyr Ala 
            180                 185                 190         


Glu Leu Val Leu Asn Lys Pro Leu Asp Arg Glu Glu Gln Pro Glu Val 
        195                 200                 205             


Asn Leu Thr Ile Thr Ala Val Asp Gly Gly Ser Pro Pro Lys Ser Gly 
    210                 215                 220                 


Thr Ala His Ile His Val Val Val Leu Asp Val Asn Asp His Val Pro 
225                 230                 235                 240 


Gln Phe Ser Arg Leu Val Tyr Arg Ala Gln Val Ser Glu Asn Ser Pro 
                245                 250                 255     


Asn Gly Ser Leu Val Ala Thr Val Thr Ala Val Asp Leu Asp Glu Gly 
            260                 265                 270         


Thr Asn Lys Ala Ile Thr Tyr Ser Leu Ala Gln Asn Pro Glu Ala Ile 
        275                 280                 285             


Leu Lys Thr Phe Gln Ile Asp Pro Gln Asn Gly Glu Val Arg Leu Arg 
    290                 295                 300                 


Gly Pro Leu Asp Phe Glu Ala Ile Glu Thr Tyr Asp Ile Asp Ile Gln 
305                 310                 315                 320 


Ala Thr Asp Gly Gly Gly Leu Ser Ala His Ser Lys Val Leu Val Glu 
                325                 330                 335     


Val Val Asp Val Asn Asp Asn Pro Pro Glu Val Met Val Ser Ser Val 
            340                 345                 350         


Ser Ser Pro Leu Pro Glu Asp Ser Pro Pro Gln Thr Val Val Ala Leu 
        355                 360                 365             


Phe Thr Ile Arg Asp Arg Asp Ile Arg Val Gly Gly Lys Val Thr Cys 
    370                 375                 380                 


Phe Leu Arg Glu Asp Leu Pro Phe Val Ile Lys Pro Thr Phe Gly Asn 
385                 390                 395                 400 


Ser Tyr Ser Leu Val Thr Asp Arg Ser Leu Asp Arg Glu Glu Val Ser 
                405                 410                 415     


Gly Tyr Asn Ile Thr Ile Val Ala Met Asp Thr Gly Pro Pro Ser Leu 
            420                 425                 430         


Ser Ala Glu Thr Met Ile Glu Val Leu Ile Ser Asp Val Asn Asp Asn 
        435                 440                 445             


Pro Pro Ile Phe Arg Glu Asp Ser Tyr Ile Leu Thr Val Arg Glu Asn 
    450                 455                 460                 


Asn Ser Pro Ala Val Phe Ile Gly Lys Val His Ala Glu Asp Leu Asp 
465                 470                 475                 480 


Leu Gly Glu Asn Ala Gln Ile Thr Tyr Ser Leu Leu Pro Pro Lys Asn 
                485                 490                 495     


Gly Asp Leu Ser Val Phe Ala Tyr Ile Ser Ile Asn Ser Gly Asn Gly 
            500                 505                 510         


Lys Leu Tyr Ala Leu Arg Thr Met Asp Tyr Glu Ala Ile Gln Asp Phe 
        515                 520                 525             


Gln Phe Val Val Lys Ala Thr Asp Gly Gly Phe Leu Ser Leu Ser Ser 
    530                 535                 540                 


Gln Val Thr Val Arg Val Val Val Leu Asp Asp Asn Asp Asn Arg Pro 
545                 550                 555                 560 


Met Ile Leu Tyr Pro Leu Gln Asn Gly Thr Leu Pro Cys Asn Asp Leu 
                565                 570                 575     


Val Pro Arg Ser Ala Glu Ala Gly Tyr Leu Val Thr Lys Val Val Ala 
            580                 585                 590         


Val Asp Gly Asp Ser Gly Gln Asn Ser Trp Leu Ser Tyr His Leu Leu 
        595                 600                 605             


Lys Ala Thr Asp Leu Gly Leu Phe Ser Val Gln Arg Gln Asn Gly Glu 
    610                 615                 620                 


Ile His Thr Leu Arg Gln Ile Ser Glu Arg Asp Pro Met Met Gln Lys 
625                 630                 635                 640 


Leu Ile Ile Leu Val Gln Asp His Gly Gln Pro Ala Leu Ser Thr Thr 
                645                 650                 655     


Val Ser Leu Asn Ile Leu Leu Val Asp Gly Phe Ser Glu Pro Tyr Leu 
            660                 665                 670         


Gln Phe Gln Asp Pro Thr Lys His Ser Arg Lys Val Asn Pro Ser Thr 
        675                 680                 685             


Lys Tyr Leu Val Ile Ser Leu Val Ile Leu Ser Phe Leu Phe Leu Leu 
    690                 695                 700                 


Ser Val Ile Val Ile Phe Ile Ile His Val Tyr Gln Lys Ile Lys Tyr 
705                 710                 715                 720 


Arg Glu Lys Phe Thr Ile Gln Glu His Phe Tyr Asp Asp Cys Asn Phe 
                725                 730                 735     


Ser Asn Asn Leu Val Gln Gly Gln Gly Asn Gly Ser Leu Ser Arg Pro 
            740                 745                 750         


Cys Pro Tyr Glu Met Cys Ser Ala Thr Gly Thr Gly Asn Ser Glu Phe 
        755                 760                 765             


Arg Phe Leu Lys Arg Phe Met Pro Asn Phe Pro Phe Pro His Ala Thr 
    770                 775                 780                 


Gly Glu Ile Lys Met Glu Ala Gly Ser Ser Leu Pro Pro Asn Ser Asp 
785                 790                 795                 800 


Arg Asn Lys Ser Gln Arg Leu Glu Gly His Asp Gln Val Ser Asp Asp 
                805                 810                 815     


Tyr Met 
        

<210>  2232
<211>  1990
<212>  DNA
<213>  Homo sapiens

<400>  2232
agcagaaaca aagcacccag ccgacgctcc ttacccagat actcagctaa agaagcagca     60

agcaggaaga ggaggctttc taaggcggtc gctccgggaa atccgggccc taggattgtc    120

cactcatccc agtatcagcg agatacgggg agatagagtt agcgacaacg tgagccagag    180

ctggagcacg tttggtgaga gaccagaaag caatggaggc cggagagggg aaggagcgcg    240

ttccgaaaca aaggcaagtc ctgatattct ttgttttgct gggcatagct caggctagtt    300

gccagcctag gcactattca gtggccgagg aaacggagag tggctccttt gtggccaatt    360

tgttaaaaga cctggggctg gagataggag aacttgctgt gaggggggcc agggtcgttt    420

ccaaaggaaa aaaaatgcat ttgcagttcg ataggcagac cggggatttg ttgttaaatg    480

agaaattgga ccgggaggag ctgtgcggcc ccacagagcc ctgtgtccta cctttccagg    540

tgttactaga aaatcccttg cagttttttc aggcggagct acggattagg gacgtaaatg    600

atcattcccc agttttccta gacaaagaaa tacttttgaa aattccagaa agtatcactc    660

ctggaactac tttcttaata gaacgtgccc aggacttgga tgtaggaacc aacagtctcc    720

aaaattacac aatcagtccc aatttccact ttcatcttaa tttacaagac agtctcgatg    780

gcataatatt accacagctg gtgctgaaca gagccctgga tcgcgaggag cagcctgaga    840

tcaggttaac cctcacagcg ctagatggcg ggagtccacc caggtccggc acggccctgg    900

tacggattga agttgtggac atcaatgaca acgtcccaga gtttgcaaag ctgctctatg    960

aggtgcagat cccggaggac agccccgttg gatcccaggt tgccatcgtc tctgccaggg   1020

atttagacat tggaactaat ggagaaatat cttatgcatt ttcccaagca tctgaagaca   1080

ttcgcaaaac gtttcgatta agtgcaaaat cgggagaact gcttttaaga cagaaactgg   1140

atttcgaatc catccagaca tacacagtaa atattcaggc gacagatggt gggggcctat   1200

ctggaacttg tgtggtattt gtccaagtga tggatttgaa tgacaatcct ccggaactaa   1260

ctatgtcgac acttatcaat cagatcccag aaaacttgca ggacaccctc attgctgtat   1320

tcagcgtttc agatcctgac tccggagaca acggaaggat ggtgtgctcc atccaagatg   1380

atcttccttt tttcttgaaa ccttctgttg agaactttta cactctggtg ataagcacgg   1440

ccctggaccg ggagaccaga tccgaataca acatcaccat caccgtcacc gactcggtgt   1500

cttcgctctt cctcttctcg gtgctcctgt tcgtggcggt gcggctgtgc aggaggagca   1560

gggcggcctc ggtgggtcgc tgctcggtgc ccgagggccc ctttccaggg cagatggtgg   1620

acgtgagcgg caccgggacc ctgtcccaga gctaccagta cgaggtgtgt ctgactggag   1680

gctccgggac aaatgagttc aagttcctga agccaattat ccccaacttc gttgctcagg   1740

gtgcagagag ggttagcgag gcaaatccca gtttcaggaa gagctttgaa ttcacttaag   1800

tgttaataag gatctactga ggctagtctc gtttaatttg tggaaagtcc ttttttactg   1860

ctttgcccat tggaggtgtc tccttttatt agaaagtaac catcttattc caattctatg   1920

catgttactg gtatttataa atgtatgagt ttttttgcgg tataataaat gtaaattttc   1980

tttgtattct                                                          1990


<210>  2233
<211>  528
<212>  PRT
<213>  Homo sapiens

<400>  2233


Met Glu Ala Gly Glu Gly Lys Glu Arg Val Pro Lys Gln Arg Gln Val 
1               5                   10                  15      


Leu Ile Phe Phe Val Leu Leu Gly Ile Ala Gln Ala Ser Cys Gln Pro 
            20                  25                  30          


Arg His Tyr Ser Val Ala Glu Glu Thr Glu Ser Gly Ser Phe Val Ala 
        35                  40                  45              


Asn Leu Leu Lys Asp Leu Gly Leu Glu Ile Gly Glu Leu Ala Val Arg 
    50                  55                  60                  


Gly Ala Arg Val Val Ser Lys Gly Lys Lys Met His Leu Gln Phe Asp 
65                  70                  75                  80  


Arg Gln Thr Gly Asp Leu Leu Leu Asn Glu Lys Leu Asp Arg Glu Glu 
                85                  90                  95      


Leu Cys Gly Pro Thr Glu Pro Cys Val Leu Pro Phe Gln Val Leu Leu 
            100                 105                 110         


Glu Asn Pro Leu Gln Phe Phe Gln Ala Glu Leu Arg Ile Arg Asp Val 
        115                 120                 125             


Asn Asp His Ser Pro Val Phe Leu Asp Lys Glu Ile Leu Leu Lys Ile 
    130                 135                 140                 


Pro Glu Ser Ile Thr Pro Gly Thr Thr Phe Leu Ile Glu Arg Ala Gln 
145                 150                 155                 160 


Asp Leu Asp Val Gly Thr Asn Ser Leu Gln Asn Tyr Thr Ile Ser Pro 
                165                 170                 175     


Asn Phe His Phe His Leu Asn Leu Gln Asp Ser Leu Asp Gly Ile Ile 
            180                 185                 190         


Leu Pro Gln Leu Val Leu Asn Arg Ala Leu Asp Arg Glu Glu Gln Pro 
        195                 200                 205             


Glu Ile Arg Leu Thr Leu Thr Ala Leu Asp Gly Gly Ser Pro Pro Arg 
    210                 215                 220                 


Ser Gly Thr Ala Leu Val Arg Ile Glu Val Val Asp Ile Asn Asp Asn 
225                 230                 235                 240 


Val Pro Glu Phe Ala Lys Leu Leu Tyr Glu Val Gln Ile Pro Glu Asp 
                245                 250                 255     


Ser Pro Val Gly Ser Gln Val Ala Ile Val Ser Ala Arg Asp Leu Asp 
            260                 265                 270         


Ile Gly Thr Asn Gly Glu Ile Ser Tyr Ala Phe Ser Gln Ala Ser Glu 
        275                 280                 285             


Asp Ile Arg Lys Thr Phe Arg Leu Ser Ala Lys Ser Gly Glu Leu Leu 
    290                 295                 300                 


Leu Arg Gln Lys Leu Asp Phe Glu Ser Ile Gln Thr Tyr Thr Val Asn 
305                 310                 315                 320 


Ile Gln Ala Thr Asp Gly Gly Gly Leu Ser Gly Thr Cys Val Val Phe 
                325                 330                 335     


Val Gln Val Met Asp Leu Asn Asp Asn Pro Pro Glu Leu Thr Met Ser 
            340                 345                 350         


Thr Leu Ile Asn Gln Ile Pro Glu Asn Leu Gln Asp Thr Leu Ile Ala 
        355                 360                 365             


Val Phe Ser Val Ser Asp Pro Asp Ser Gly Asp Asn Gly Arg Met Val 
    370                 375                 380                 


Cys Ser Ile Gln Asp Asp Leu Pro Phe Phe Leu Lys Pro Ser Val Glu 
385                 390                 395                 400 


Asn Phe Tyr Thr Leu Val Ile Ser Thr Ala Leu Asp Arg Glu Thr Arg 
                405                 410                 415     


Ser Glu Tyr Asn Ile Thr Ile Thr Val Thr Asp Ser Val Ser Ser Leu 
            420                 425                 430         


Phe Leu Phe Ser Val Leu Leu Phe Val Ala Val Arg Leu Cys Arg Arg 
        435                 440                 445             


Ser Arg Ala Ala Ser Val Gly Arg Cys Ser Val Pro Glu Gly Pro Phe 
    450                 455                 460                 


Pro Gly Gln Met Val Asp Val Ser Gly Thr Gly Thr Leu Ser Gln Ser 
465                 470                 475                 480 


Tyr Gln Tyr Glu Val Cys Leu Thr Gly Gly Ser Gly Thr Asn Glu Phe 
                485                 490                 495     


Lys Phe Leu Lys Pro Ile Ile Pro Asn Phe Val Ala Gln Gly Ala Glu 
            500                 505                 510         


Arg Val Ser Glu Ala Asn Pro Ser Phe Arg Lys Ser Phe Glu Phe Thr 
        515                 520                 525             

<210>  2234
<211>  2344
<212>  DNA
<213>  Homo sapiens

<400>  2234
ccttacccag atactcagct aaagaagcag caagcaggaa gaggaggctt tctaaggcgg     60

tcgctccggg aaatccgggc cctaggattg tccactcatc ccagtatcag cgagatacgg    120

ggagatagag ttagcgacaa cgtgagccag agctggagca cgtttggtga gagaccagaa    180

agcaatggag gccggagagg ggaaggagcg cgttccgaaa caaagaacgt gcccaggact    240

tggatgtagg aaccaacagt ctccaaaatt acacaatcag tcccaatttc cactttcatc    300

ttaatttaca agacagtctc gatggcataa tattaccaca gctggtgctg aacagagccc    360

tggatcgcga ggagcagcct gagatcaggt taaccctcac agcgctagat ggcgggagtc    420

cacccaggtc cggcacggcc ctggtacgga ttgaagttgt ggacatcaat gacaacgtcc    480

cagagtttgc aaagctgctc tatgaggtgc agatcccgga ggacagcccc gttggatccc    540

aggttgccat cgtctctgcc agggatttag acattggaac taatggagaa atatcttatg    600

cattttccca agcatctgaa gacattcgca aaacgtttcg attaagtgca aaatcgggag    660

aactgctttt aagacagaaa ctggatttcg aatccatcca gacatacaca gtaaatattc    720

aggcgacaga tggtgggggc ctatctggaa cttgtgtggt atttgtccaa gtgatggatt    780

tgaatgacaa tcctccggaa ctaactatgt cgacacttat caatcagatc ccagaaaact    840

tgcaggacac cctcattgct gtattcagcg tttcagatcc tgactccgga gacaacggaa    900

ggatggtgtg ctccatccaa gatgatcttc cttttttctt gaaaccttct gttgagaact    960

tttacactct ggtgataagc acggccctgg accgggagac cagatccgaa tacaacatca   1020

ccatcaccgt caccgacttc gggacaccca ggctgaaaac cgagcacaac ataaccgtgc   1080

tggtctccga cgtcaatgac aacgcccccg ccttcaccca aacctcctac accctgttcg   1140

tccgcgagaa caacagcccc gccctgcaca tcggcagcgt cagcgccaca gacagagact   1200

cgggcaccaa cgcccaggtc acctactcgc tgctgccgcc ccaggacccg cacctgcccc   1260

tcgcctccct ggtctccatc aacgcggaca acggccacct gttcgctctc cagtcgctgg   1320

actacgaggc cctgcaggcg ttcgagttcc gcgtgggcgc cgcagaccgc ggctccccgg   1380

cgttgagcag cgaggcgctg gtgcgcgtgc tggtgctgga cgccaacgac aactcgccct   1440

tcgtgctgta cccgctgcag aacggctccg cgccctgcac cgagctggtg ccccgggcgg   1500

ccgagccggg ctacctggtg accaaggtgg tggcggtgga cggcgactcg ggccagaacg   1560

cctggctgtc gtaccagctg ctcaaggcca cggagcccgg gctgttcggc gtgtgggcgc   1620

acaatggcga ggtgcgcacc gccaggctgc tgagggagcg cgacgctgcc aagcagaggc   1680

tggtggtgct ggtcaaggac aatggcgagc ctccgcgctc ggccaccgcc acgctgcacg   1740

tgctcctggt ggacggcttc tcccagccct acctgctgct cccggaggcg gcaccggccc   1800

aggcccaggc cgacttgctc accgtctacc tggtggtggc gttggcctcg gtgtcttcgc   1860

tcttcctctt ctcggtgctc ctgttcgtgg cggtgcggct gtgcaggagg agcagggcgg   1920

cctcggtggg tcgctgctcg gtgcccgagg gcccctttcc agggcagatg gtggacgtga   1980

gcggcaccgg gaccctgtcc cagagctacc agtacgaggt gtgtctgact ggaggctccg   2040

ggacaaatga gttcaagttc ctgaagccaa ttatccccaa cttcgttgct cagggtgcag   2100

agagggttag cgaggcaaat cccagtttca ggaagagctt tgaattcact taagtgttaa   2160

taaggatcta ctgaggctag tctcgtttaa tttgtggaaa gtcctttttt actgctttgc   2220

ccattggagg tgtctccttt tattagaaag taaccatctt attccaattc tatgcatgtt   2280

actggtattt ataaatgtat gagttttttt gcggtataat aaatgtaaat tttctttgta   2340

ttct                                                                2344


<210>  2235
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  2235


Met Glu Ala Gly Glu Gly Lys Glu Arg Val Pro Lys Gln Arg Thr Cys 
1               5                   10                  15      


Pro Gly Leu Gly Cys Arg Asn Gln Gln Ser Pro Lys Leu His Asn Gln 
            20                  25                  30          


Ser Gln Phe Pro Leu Ser Ser 
        35                  

<210>  2236
<211>  1850
<212>  DNA
<213>  Homo sapiens

<400>  2236
acccagatac tcagctaaag aagcagcaag caggaagagg aggctttcta aggcggtcgc     60

tccgggaaat ccgggcccta ggattgtcca ctcatcccag tatcagcgag atacggggag    120

atagagttag cgacaacgtg agccagagct ggagcacgtt tggtgagaga ccagaaagca    180

atggaggccg gagaggggaa ggagcgcgtt ccgaaacaaa ggcaagtcct gatattcttt    240

gttttgctgg gcatagctca ggctagttgc cagcctaggc actattcagt ggccgaggaa    300

acggagagtg gctcctttgt ggccaatttg ttaaaagacc tggggctgga gataggagaa    360

cttgctgtat tcagcgtttc agatcctgac tccggagaca acggaaggat ggtgtgctcc    420

atccaagatg atcttccttt tttcttgaaa ccttctgttg agaactttta cactctggtg    480

ataagcacgg ccctggaccg ggagaccaga tccgaataca acatcaccat caccgtcacc    540

gacttcggga cacccaggct gaaaaccgag cacaacataa ccgtgctggt ctccgacgtc    600

aatgacaacg cccccgcctt cacccaaacc tcctacaccc tgttcgtccg cgagaacaac    660

agccccgccc tgcacatcgg cagcgtcagc gccacagaca gagactcggg caccaacgcc    720

caggtcacct actcgctgct gccgccccag gacccgcacc tgcccctcgc ctccctggtc    780

tccatcaacg cggacaacgg ccacctgttc gctctccagt cgctggacta cgaggccctg    840

caggcgttcg agttccgcgt gggcgccgca gaccgcggct ccccggcgtt gagcagcgag    900

gcgctggtgc gcgtgctggt gctggacgcc aacgacaact cgcccttcgt gctgtacccg    960

ctgcagaacg gctccgcgcc ctgcaccgag ctggtgcccc gggcggccga gccgggctac   1020

ctggtgacca aggtggtggc ggtggacggc gactcgggcc agaacgcctg gctgtcgtac   1080

cagctgctca aggccacgga gcccgggctg ttcggcgtgt gggcgcacaa tggcgaggtg   1140

cgcaccgcca ggctgctgag ggagcgcgac gctgccaagc agaggctggt ggtgctggtc   1200

aaggacaatg gcgagcctcc gcgctcggcc accgccacgc tgcacgtgct cctggtggac   1260

ggcttctccc agccctacct gctgctcccg gaggcggcac cggcccaggc ccaggccgac   1320

ttgctcaccg tctacctggt ggtggcgttg gcctcggtgt cttcgctctt cctcttctcg   1380

gtgctcctgt tcgtggcggt gcggctgtgc aggaggagca gggcggcctc ggtgggtcgc   1440

tgctcggtgc ccgagggccc ctttccaggg cagatggtgg acgtgagcgg caccgggacc   1500

ctgtcccaga gctaccagta cgaggtgtgt ctgactggag gctccgggac aaatgagttc   1560

aagttcctga agccaattat ccccaacttc gttgctcagg gtgcagagag ggttagcgag   1620

gcaaatccca gtttcaggaa gagctttgaa ttcacttaag tgttaataag gatctactga   1680

ggctagtctc gtttaatttg tggaaagtcc ttttttactg ctttgcccat tggaggtgtc   1740

tccttttatt agaaagtaac catcttattc caattctatg catgttactg gtatttataa   1800

atgtatgagt ttttttgcgg tataataaat gtaaattttc tttgtattct              1850


<210>  2237
<211>  492
<212>  PRT
<213>  Homo sapiens

<400>  2237


Met Glu Ala Gly Glu Gly Lys Glu Arg Val Pro Lys Gln Arg Gln Val 
1               5                   10                  15      


Leu Ile Phe Phe Val Leu Leu Gly Ile Ala Gln Ala Ser Cys Gln Pro 
            20                  25                  30          


Arg His Tyr Ser Val Ala Glu Glu Thr Glu Ser Gly Ser Phe Val Ala 
        35                  40                  45              


Asn Leu Leu Lys Asp Leu Gly Leu Glu Ile Gly Glu Leu Ala Val Phe 
    50                  55                  60                  


Ser Val Ser Asp Pro Asp Ser Gly Asp Asn Gly Arg Met Val Cys Ser 
65                  70                  75                  80  


Ile Gln Asp Asp Leu Pro Phe Phe Leu Lys Pro Ser Val Glu Asn Phe 
                85                  90                  95      


Tyr Thr Leu Val Ile Ser Thr Ala Leu Asp Arg Glu Thr Arg Ser Glu 
            100                 105                 110         


Tyr Asn Ile Thr Ile Thr Val Thr Asp Phe Gly Thr Pro Arg Leu Lys 
        115                 120                 125             


Thr Glu His Asn Ile Thr Val Leu Val Ser Asp Val Asn Asp Asn Ala 
    130                 135                 140                 


Pro Ala Phe Thr Gln Thr Ser Tyr Thr Leu Phe Val Arg Glu Asn Asn 
145                 150                 155                 160 


Ser Pro Ala Leu His Ile Gly Ser Val Ser Ala Thr Asp Arg Asp Ser 
                165                 170                 175     


Gly Thr Asn Ala Gln Val Thr Tyr Ser Leu Leu Pro Pro Gln Asp Pro 
            180                 185                 190         


His Leu Pro Leu Ala Ser Leu Val Ser Ile Asn Ala Asp Asn Gly His 
        195                 200                 205             


Leu Phe Ala Leu Gln Ser Leu Asp Tyr Glu Ala Leu Gln Ala Phe Glu 
    210                 215                 220                 


Phe Arg Val Gly Ala Ala Asp Arg Gly Ser Pro Ala Leu Ser Ser Glu 
225                 230                 235                 240 


Ala Leu Val Arg Val Leu Val Leu Asp Ala Asn Asp Asn Ser Pro Phe 
                245                 250                 255     


Val Leu Tyr Pro Leu Gln Asn Gly Ser Ala Pro Cys Thr Glu Leu Val 
            260                 265                 270         


Pro Arg Ala Ala Glu Pro Gly Tyr Leu Val Thr Lys Val Val Ala Val 
        275                 280                 285             


Asp Gly Asp Ser Gly Gln Asn Ala Trp Leu Ser Tyr Gln Leu Leu Lys 
    290                 295                 300                 


Ala Thr Glu Pro Gly Leu Phe Gly Val Trp Ala His Asn Gly Glu Val 
305                 310                 315                 320 


Arg Thr Ala Arg Leu Leu Arg Glu Arg Asp Ala Ala Lys Gln Arg Leu 
                325                 330                 335     


Val Val Leu Val Lys Asp Asn Gly Glu Pro Pro Arg Ser Ala Thr Ala 
            340                 345                 350         


Thr Leu His Val Leu Leu Val Asp Gly Phe Ser Gln Pro Tyr Leu Leu 
        355                 360                 365             


Leu Pro Glu Ala Ala Pro Ala Gln Ala Gln Ala Asp Leu Leu Thr Val 
    370                 375                 380                 


Tyr Leu Val Val Ala Leu Ala Ser Val Ser Ser Leu Phe Leu Phe Ser 
385                 390                 395                 400 


Val Leu Leu Phe Val Ala Val Arg Leu Cys Arg Arg Ser Arg Ala Ala 
                405                 410                 415     


Ser Val Gly Arg Cys Ser Val Pro Glu Gly Pro Phe Pro Gly Gln Met 
            420                 425                 430         


Val Asp Val Ser Gly Thr Gly Thr Leu Ser Gln Ser Tyr Gln Tyr Glu 
        435                 440                 445             


Val Cys Leu Thr Gly Gly Ser Gly Thr Asn Glu Phe Lys Phe Leu Lys 
    450                 455                 460                 


Pro Ile Ile Pro Asn Phe Val Ala Gln Gly Ala Glu Arg Val Ser Glu 
465                 470                 475                 480 


Ala Asn Pro Ser Phe Arg Lys Ser Phe Glu Phe Thr 
                485                 490         

<210>  2238
<211>  2362
<212>  DNA
<213>  Homo sapiens

<400>  2238
cagctaaaga agcagcaagc aggaagagga ggctttctaa ggcggtcgct ccgggaaatc     60

cgggccctag gattgtccac tcatcccagt atcagcgaga tacggggaga tagagttagc    120

gacaacgtga gccagagctg gagcacgttt ggtgagagac cagaaagcaa tggaggccgg    180

agaggggaag gagcgcgttc cgaaacaaag aaagtatcac tcctggaact actttcttaa    240

tagaacgtgc ccaggacttg gatgtaggaa ccaacagtct ccaaaattac acaatcagtc    300

ccaatttcca ctttcatctt aatttacaag acagtctcga tggcataata ttaccacagc    360

tggtgctgaa cagagccctg gatcgcgagg agcagcctga gatcaggtta accctcacag    420

cgctagatgg cgggagtcca cccaggtccg gcacggccct ggtacggatt gaagttgtgg    480

acatcaatga caacgtccca gagtttgcaa agctgctcta tgaggtgcag atcccggagg    540

acagccccgt tggatcccag gttgccatcg tctctgccag ggatttagac attggaacta    600

atggagaaat atcttatgca ttttcccaag catctgaaga cattcgcaaa acgtttcgat    660

taagtgcaaa atcgggagaa ctgcttttaa gacagaaact ggatttcgaa tccatccaga    720

catacacagt aaatattcag gcgacagatg gtgggggcct atctggaact tgtgtggtat    780

ttgtccaagt gatggatttg aatgacaatc ctccggaact aactatgtcg acacttatca    840

atcagatccc agaaaacttg caggacaccc tcattgctgt attcagcgtt tcagatcctg    900

actccggaga caacggaagg atggtgtgct ccatccaaga tgatcttcct tttttcttga    960

aaccttctgt tgagaacttt tacactctgg tgataagcac ggccctggac cgggagacca   1020

gatccgaata caacatcacc atcaccgtca ccgacttcgg gacacccagg ctgaaaaccg   1080

agcacaacat aaccgtgctg gtctccgacg tcaatgacaa cgcccccgcc ttcacccaaa   1140

cctcctacac cctgttcgtc cgcgagaaca acagccccgc cctgcacatc ggcagcgtca   1200

gcgccacaga cagagactcg ggcaccaacg cccaggtcac ctactcgctg ctgccgcccc   1260

aggacccgca cctgcccctc gcctccctgg tctccatcaa cgcggacaac ggccacctgt   1320

tcgctctcca gtcgctggac tacgaggccc tgcaggcgtt cgagttccgc gtgggcgccg   1380

cagaccgcgg ctccccggcg ttgagcagcg aggcgctggt gcgcgtgctg gtgctggacg   1440

ccaacgacaa ctcgcccttc gtgctgtacc cgctgcagaa cggctccgcg ccctgcaccg   1500

agctggtgcc ccgggcggcc gagccgggct acctggtgac caaggtggtg gcggtggacg   1560

gcgactcggg ccagaacgcc tggctgtcgt accagctgct caaggccacg gagcccgggc   1620

tgttcggcgt gtgggcgcac aatggcgagg tgcgcaccgc caggctgctg agggagcgcg   1680

acgctgccaa gcagaggctg gtggtgctgg tcaaggacaa tggcgagcct ccgcgctcgg   1740

ccaccgccac gctgcacgtg ctcctggtgg acggcttctc ccagccctac ctgctgctcc   1800

cggaggcggc accggcccag gcccaggccg acttgctcac cgtctacctg gtggtggcgt   1860

tggcctcggt gtcttcgctc ttcctcttct cggtgctcct gttcgtggcg gtgcggctgt   1920

gcaggaggag cagggcggcc tcggtgggtc gctgctcggt gcccgagggc ccctttccag   1980

ggcagatggt ggacgtgagc ggcaccggga ccctgtccca gagctaccag tacgaggtgt   2040

gtctgactgg aggctccggg acaaatgagt tcaagttcct gaagccaatt atccccaact   2100

tcgttgctca gggtgcagag agggttagcg aggcaaatcc cagtttcagg aagagctttg   2160

aattcactta agtgttaata aggatctact gaggctagtc tcgtttaatt tgtggaaagt   2220

ccttttttac tgctttgccc attggaggtg tctcctttta ttagaaagta accatcttat   2280

tccaattcta tgcatgttac tggtatttat aaatgtatga gtttttttgc ggtataataa   2340

atgtaaattt tctttgtatt ct                                            2362


<210>  2239
<211>  50
<212>  PRT
<213>  Homo sapiens

<400>  2239


Met Glu Ala Gly Glu Gly Lys Glu Arg Val Pro Lys Gln Arg Lys Tyr 
1               5                   10                  15      


His Ser Trp Asn Tyr Phe Leu Asn Arg Thr Cys Pro Gly Leu Gly Cys 
            20                  25                  30          


Arg Asn Gln Gln Ser Pro Lys Leu His Asn Gln Ser Gln Phe Pro Leu 
        35                  40                  45              


Ser Ser 
    50  

<210>  2240
<211>  794
<212>  DNA
<213>  Homo sapiens

<400>  2240
aaagaagcag caagcaggaa gaggaggctt tctaaggcgg tcgctccggg aaatccgggc     60

cctaggattg tccactcatc ccagtatcag cgagatacgg ggagatagag ttagcgacaa    120

cgtgagccag agctggagca cgtttggtga gagaccagaa agcaatggag gccggagagg    180

ggaaggagcg cgttccgaaa caaaggcaat ctcgatggca taatattacc acagctggtg    240

ctgaacagag ccctggatcg cgaggagcag cctgagatca ggttaaccct cacagcgcta    300

gatggcggga gtccacccag gtccggcacg gccctggtac ggattgaagt tgtggacatc    360

aatgacaacg tcccagagtt tgcaaagctg ctctatgagg tgcagatccc ggaggacagc    420

cccgttggat cccaggttgc catcgtctct gccagggatt tagacattgg aactaatgga    480

gaaatatctt atgcattttc ccaagcatct gaagacattc gcaaaacgtt tcgattaagt    540

gcaaaatcgg gagaactgct tttaagacag aaactggatt tcgaatccat ccagacatac    600

acagtaaata ttcaggcgac agatggtggg ggcctatctg gaacttgtgt ggtatttgtc    660

caagtgatgg atttgaatga caatcctccg gaactaacta tgtcgacact tatcaatcag    720

atcccagaaa acttgcagga caccctcatt gctgtattca gcgtttcaga tcctgactcc    780

ggagacaacg gaag                                                      794


<210>  2241
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  2241


Met Glu Ala Gly Glu Gly Lys Glu Arg Val Pro Lys Gln Arg Gln Ser 
1               5                   10                  15      


Arg Trp His Asn Ile Thr Thr Ala Gly Ala Glu Gln Ser Pro Gly Ser 
            20                  25                  30          


Arg Gly Ala Ala 
        35      

<210>  2242
<211>  2744
<212>  DNA
<213>  Homo sapiens

<400>  2242
agcaagcagg aagaggaggc tttctaaggc ggtcgctccg ggaaatccgg gccctaggat     60

tgtccactca tcccagtatc agcgagatac ggggagatag agttagcgac aacgtgagcc    120

agagctggag cacgtttggt gagagaccag aaagcaatgg aggccggaga ggggaaggag    180

cgcgttccga aacaaaggca agtcctgata ttctttgttt tgctgggcat agctcaggct    240

agttgccagc ctaggcacta ttcagtggcc gaggaaacgg agagtggctc ctttgtggcc    300

aatttgttaa aagacctggg gctggagata ggagaacttg ctgtgagggg ggccagggtc    360

gtttccaaag gaaaaaaaat gcatttgcag ttcgataggc agaccgggga tttgttgtta    420

aatgagaaat tggaccggga ggagctgtgc ggccccacag agccctgtgt cctacctttc    480

caggtgttac tagaaaatcc cttgcagttt tttcaggcgg agctacggat tagggacgta    540

aatgatcatt ccccagtttt cctagacaaa gaaatacttt tgaaaattcc agaaagtatc    600

actcctggaa ctactttctt aatagaacgt gcccaggact tggatgtagg aaccaacagt    660

ctccaaaatt acacaatcag tcccaatttc cactttcatc ttaatttaca agacagtctc    720

gatggcataa tattaccaca gctggtgctg aacagagccc tggatcgcga ggagcagcct    780

gagatcaggt taaccctcac agcgctagat ggcgggagtc cacccaggtc cggcacggcc    840

ctggtacgga ttgaagttgt ggacatcaat gacaacgtcc cagagtttgc aaagctgctc    900

tatgaggtgc agatcccgga ggacagcccc gttggatccc aggttgccat cgtctctgcc    960

agggatttag acattggaac taatggagaa atatcttatg cattttccca agcatctgaa   1020

gacattcgca aaacgtttcg attaagtgca aaatcgggag aactgctttt aagacagaaa   1080

ctggatttcg aatccatcca gacatacaca gtaaatattc aggcgacaga tggtgggggc   1140

ctatctggaa cttgtgtggt atttgtccaa gtgatggatt tgaatgacaa tcctccggaa   1200

ctaactatgt cgacacttat caatcagatc ccagaaaact tgcaggacac cctcattgct   1260

gtattcagcg tttcagatcc tgactccgga gacaacggaa ggatggtgtg ctccatccaa   1320

gatgatcttc cttttttctt gaaaccttct gttgagaact tttacactct ggtgataagc   1380

acggccctgg accgggagac cagatccgaa tacaacatca ccatcaccgt caccgacttc   1440

gggacaccca ggctgaaaac cgagcacaac ataaccgtgc tggtctccga cgtcaatgac   1500

aacgcccccg ccttcaccca aacctcctac accctgttcg tccgcgagaa caacagcccc   1560

gccctgcaca tcggcagcgt cagcgccaca gacagagact cgggcaccaa cgcccaggtc   1620

acctactcgc tgctgccgcc ccaggacccg cacctgcccc tcgcctccct ggtctccatc   1680

aacgcggaca acggccacct gttcgctctc cagtcgctgg actacgaggc cctgcaggcg   1740

ttcgagttcc gcgtgggcgc cgcagaccgc ggctccccgg cgttgagcag cgaggcgctg   1800

gtgcgcgtgc tggtgctgga cgccaacgac aactcgccct tcgtgctgta cccgctgcag   1860

aacggctccg cgccctgcac cgagctggtg ccccgggcgg ccgagccggg ctacctggtg   1920

accaaggtgg tggcggtgga cggcgactcg ggccagaacg cctggctgtc gtaccagctg   1980

ctcaaggcca cggagcccgg gctgttcggc gtgtgggcgc acaatggcga ggtgcgcacc   2040

gccaggctgc tgagggagcg cgacgctgcc aagcagaggc tggtggtgct ggtcaaggac   2100

aatggcgagc ctccgcgctc ggccaccgcc acgctgcacg tgctcctggt ggacggcttc   2160

tcccagccct acctgctgct cccggaggcg gcaccggccc aggcccaggc cgacttgctc   2220

accgtctacc tggtggtggc gttggcctcg gtgtcttcgc tcttcctctt ctcggtgctc   2280

ctgttcgtgg cggtgcggct gtgcaggagg agcagggcgg cctcggtggg tcgctgctcg   2340

gtgcccgagg gcccctttcc agggcagatg gtggacgtga gcggcaccgg gaccctgtcc   2400

cagagctacc agtacgaggt gtgtctgact ggaggctccg ggacaaatga gttcaagttc   2460

ctgaagccaa ttatccccaa cttcgttgct cagggtgcag agagggttag cgaggcaaat   2520

cccagtttca ggaagagctt tgaattcact taagtgttaa taaggatcta ctgaggctag   2580

tctcgtttaa tttgtggaaa gtcctttttt actgctttgc ccattggagg tgtctccttt   2640

tattagaaag taaccatctt attccaattc tatgcatgtt actggtattt ataaatgtat   2700

gagttttttt gcggtataat aaatgtaaat tttctttgta ttct                    2744


<210>  2243
<211>  798
<212>  PRT
<213>  Homo sapiens

<400>  2243


Met Glu Ala Gly Glu Gly Lys Glu Arg Val Pro Lys Gln Arg Gln Val 
1               5                   10                  15      


Leu Ile Phe Phe Val Leu Leu Gly Ile Ala Gln Ala Ser Cys Gln Pro 
            20                  25                  30          


Arg His Tyr Ser Val Ala Glu Glu Thr Glu Ser Gly Ser Phe Val Ala 
        35                  40                  45              


Asn Leu Leu Lys Asp Leu Gly Leu Glu Ile Gly Glu Leu Ala Val Arg 
    50                  55                  60                  


Gly Ala Arg Val Val Ser Lys Gly Lys Lys Met His Leu Gln Phe Asp 
65                  70                  75                  80  


Arg Gln Thr Gly Asp Leu Leu Leu Asn Glu Lys Leu Asp Arg Glu Glu 
                85                  90                  95      


Leu Cys Gly Pro Thr Glu Pro Cys Val Leu Pro Phe Gln Val Leu Leu 
            100                 105                 110         


Glu Asn Pro Leu Gln Phe Phe Gln Ala Glu Leu Arg Ile Arg Asp Val 
        115                 120                 125             


Asn Asp His Ser Pro Val Phe Leu Asp Lys Glu Ile Leu Leu Lys Ile 
    130                 135                 140                 


Pro Glu Ser Ile Thr Pro Gly Thr Thr Phe Leu Ile Glu Arg Ala Gln 
145                 150                 155                 160 


Asp Leu Asp Val Gly Thr Asn Ser Leu Gln Asn Tyr Thr Ile Ser Pro 
                165                 170                 175     


Asn Phe His Phe His Leu Asn Leu Gln Asp Ser Leu Asp Gly Ile Ile 
            180                 185                 190         


Leu Pro Gln Leu Val Leu Asn Arg Ala Leu Asp Arg Glu Glu Gln Pro 
        195                 200                 205             


Glu Ile Arg Leu Thr Leu Thr Ala Leu Asp Gly Gly Ser Pro Pro Arg 
    210                 215                 220                 


Ser Gly Thr Ala Leu Val Arg Ile Glu Val Val Asp Ile Asn Asp Asn 
225                 230                 235                 240 


Val Pro Glu Phe Ala Lys Leu Leu Tyr Glu Val Gln Ile Pro Glu Asp 
                245                 250                 255     


Ser Pro Val Gly Ser Gln Val Ala Ile Val Ser Ala Arg Asp Leu Asp 
            260                 265                 270         


Ile Gly Thr Asn Gly Glu Ile Ser Tyr Ala Phe Ser Gln Ala Ser Glu 
        275                 280                 285             


Asp Ile Arg Lys Thr Phe Arg Leu Ser Ala Lys Ser Gly Glu Leu Leu 
    290                 295                 300                 


Leu Arg Gln Lys Leu Asp Phe Glu Ser Ile Gln Thr Tyr Thr Val Asn 
305                 310                 315                 320 


Ile Gln Ala Thr Asp Gly Gly Gly Leu Ser Gly Thr Cys Val Val Phe 
                325                 330                 335     


Val Gln Val Met Asp Leu Asn Asp Asn Pro Pro Glu Leu Thr Met Ser 
            340                 345                 350         


Thr Leu Ile Asn Gln Ile Pro Glu Asn Leu Gln Asp Thr Leu Ile Ala 
        355                 360                 365             


Val Phe Ser Val Ser Asp Pro Asp Ser Gly Asp Asn Gly Arg Met Val 
    370                 375                 380                 


Cys Ser Ile Gln Asp Asp Leu Pro Phe Phe Leu Lys Pro Ser Val Glu 
385                 390                 395                 400 


Asn Phe Tyr Thr Leu Val Ile Ser Thr Ala Leu Asp Arg Glu Thr Arg 
                405                 410                 415     


Ser Glu Tyr Asn Ile Thr Ile Thr Val Thr Asp Phe Gly Thr Pro Arg 
            420                 425                 430         


Leu Lys Thr Glu His Asn Ile Thr Val Leu Val Ser Asp Val Asn Asp 
        435                 440                 445             


Asn Ala Pro Ala Phe Thr Gln Thr Ser Tyr Thr Leu Phe Val Arg Glu 
    450                 455                 460                 


Asn Asn Ser Pro Ala Leu His Ile Gly Ser Val Ser Ala Thr Asp Arg 
465                 470                 475                 480 


Asp Ser Gly Thr Asn Ala Gln Val Thr Tyr Ser Leu Leu Pro Pro Gln 
                485                 490                 495     


Asp Pro His Leu Pro Leu Ala Ser Leu Val Ser Ile Asn Ala Asp Asn 
            500                 505                 510         


Gly His Leu Phe Ala Leu Gln Ser Leu Asp Tyr Glu Ala Leu Gln Ala 
        515                 520                 525             


Phe Glu Phe Arg Val Gly Ala Ala Asp Arg Gly Ser Pro Ala Leu Ser 
    530                 535                 540                 


Ser Glu Ala Leu Val Arg Val Leu Val Leu Asp Ala Asn Asp Asn Ser 
545                 550                 555                 560 


Pro Phe Val Leu Tyr Pro Leu Gln Asn Gly Ser Ala Pro Cys Thr Glu 
                565                 570                 575     


Leu Val Pro Arg Ala Ala Glu Pro Gly Tyr Leu Val Thr Lys Val Val 
            580                 585                 590         


Ala Val Asp Gly Asp Ser Gly Gln Asn Ala Trp Leu Ser Tyr Gln Leu 
        595                 600                 605             


Leu Lys Ala Thr Glu Pro Gly Leu Phe Gly Val Trp Ala His Asn Gly 
    610                 615                 620                 


Glu Val Arg Thr Ala Arg Leu Leu Arg Glu Arg Asp Ala Ala Lys Gln 
625                 630                 635                 640 


Arg Leu Val Val Leu Val Lys Asp Asn Gly Glu Pro Pro Arg Ser Ala 
                645                 650                 655     


Thr Ala Thr Leu His Val Leu Leu Val Asp Gly Phe Ser Gln Pro Tyr 
            660                 665                 670         


Leu Leu Leu Pro Glu Ala Ala Pro Ala Gln Ala Gln Ala Asp Leu Leu 
        675                 680                 685             


Thr Val Tyr Leu Val Val Ala Leu Ala Ser Val Ser Ser Leu Phe Leu 
    690                 695                 700                 


Phe Ser Val Leu Leu Phe Val Ala Val Arg Leu Cys Arg Arg Ser Arg 
705                 710                 715                 720 


Ala Ala Ser Val Gly Arg Cys Ser Val Pro Glu Gly Pro Phe Pro Gly 
                725                 730                 735     


Gln Met Val Asp Val Ser Gly Thr Gly Thr Leu Ser Gln Ser Tyr Gln 
            740                 745                 750         


Tyr Glu Val Cys Leu Thr Gly Gly Ser Gly Thr Asn Glu Phe Lys Phe 
        755                 760                 765             


Leu Lys Pro Ile Ile Pro Asn Phe Val Ala Gln Gly Ala Glu Arg Val 
    770                 775                 780                 


Ser Glu Ala Asn Pro Ser Phe Arg Lys Ser Phe Glu Phe Thr 
785                 790                 795             

<210>  2244
<211>  1178
<212>  DNA
<213>  Homo sapiens

<400>  2244
agtccagcga ctggagagcg aacaggtggc cgttgtccgc gttgatggag accagggagg     60

cgaggggcag cctgggtgtc ccgaagtcgg tgacggtgat ggtgatgttg tattcggatc    120

tggtctcccg gtccagggcc gtgcttatca ccagagtgta aaagttctca acagaaggtt    180

tcaagaaaaa aggaagatca tcttggatgg agcacaccat ccttccgttg tctccggagt    240

caggatctga aacgctgaat acagcaatga gggtgtcctg caagttttct gggatctgat    300

tgataagtgt cgacatagtt agttccggag gattgtcatt caaatccatc acttggacaa    360

ataccacaca agttccagat aggcccccac catctgtcgc ctgaatattt actgtgtatg    420

tctggatgga ttcgaaatcc agtttctgtc ttaaaagcag ttctcccgat tttgcactta    480

atcgaaacgt tttgcgaatg tcttcagatg cttgggaaaa tgcataagat atttctccat    540

tagttccaat gtctaaatcc ctggcagaga cgatggcaac ctgggatcca acggggctgt    600

cctccgggat ctgcacctca tagagcagct ttgcaaactc tgggacgttg tcattgatgt    660

ccacaacttc aatccgtacc agggccgtgc cggacctggg tggactcccg ccatctagcg    720

ctgtgagggt taacctgatc tcaggctgct cctcgcgatc cagggctctg ttcagcacca    780

gctgtggtaa tattatgcca tcgagactgt cttgtaaatt aagatgaaag tggaaattgg    840

gactgattgt gtaattttgg agactgttgg ttcctacatc caagtcctgg gcacgttcta    900

ttaagaaagt agttccagga gtgatacttt ctggaatttt caaaagtatt tctttgtcta    960

ggaaaactgg ggaatgatca tttacgtccc taatccgtag ctccgcctga aaaaactgca   1020

agggattttc tagtaacacc tggaaaggta ggacacaggg ctctgtgggg ccgcacagct   1080

cctcccggtc caatttctca tttaacaaca aatccccggt ctgcctatcg aactgcaaat   1140

gcattttttt tcctttggaa acgaccctgg cccccctc                           1178


<210>  2245
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  2245


Met Glu Thr Arg Glu Ala Arg Gly Ser Leu Gly Val Pro Lys Ser Val 
1               5                   10                  15      


Thr Val Met Val Met Leu Tyr Ser Asp Leu Val Ser Arg Ser Arg Ala 
            20                  25                  30          


Val Leu Ile Thr Arg Val 
        35              

<210>  2246
<211>  1171
<212>  DNA
<213>  Homo sapiens

<400>  2246
gaacgtgccc aggacttgga tgtaggaacc aacagtctcc aaaattacac aatcagtccc     60

aatttccact ttcatcttaa tttacaagac agtctcgatg gcataatatt accacagctg    120

gtgctgaaca gagccctgga tcgcgaggag cagcctgaga tcaggttaac cctcacagcg    180

ctagatggcg ggagtccacc caggtccggc acggccctgg tacggattga agttgtggac    240

atcaatgaca acgtcccaga gtttgcaaag ctgctctatg aggtgcagat cccggaggac    300

agccccgttg gatcccaggt tgccatcgtc tctgccaggg atttagacat tggaactaat    360

ggagaaatat cttatgcatt ttcccaagca tctgaagaca ttcgcaaaac gtttcgatta    420

agtgcaaaat cgggagaact gcttttaaga cagaaactgg atttcgaatc catccagaca    480

tacacagtaa atattcaggc gacagatggt gggggcctat ctggaacttg tgtggtattt    540

gtccaagtga tggatttgaa tgacaatcct ccggaactaa ctatgtcgac acttatcaat    600

cagatcccag aaaacttgca ggacaccctc attgctgtat tcagcgtttc agatcctgac    660

tccggagaca acggaaggat ggtgtgctcc atccaagatg atcttccttt tttcttgaaa    720

ccttctgttg agaactttta cactctggtg ataagcacgg ccctggaccg ggagaccaga    780

tccgaataca acatcaccat caccgtcacc gacttcggga cctgtcccag agctaccagt    840

acgaggtgtg tctgactgga ggctccggga caaatgagtt caagttcctg aagccaatta    900

tccccaactt cgttgctcag ggtgcagaga gggttagcga ggcaaatccc agtttcagga    960

agagctttga attcacttaa gtgttaataa ggatctactg aggctagtct cgtttaattt   1020

gtggaaagtc cttttttact gctttgccca ttggaggtgt ctccttttat tagaaagtaa   1080

ccatcttatt ccaattctat gcatgttact ggtatttata aatgtatgag tttttttgcg   1140

gtataataaa tgtaaatttt ctttgtattc t                                  1171


<210>  2247
<211>  101
<212>  PRT
<213>  Homo sapiens

<400>  2247


Met Asp Leu Asn Asp Asn Pro Pro Glu Leu Thr Met Ser Thr Leu Ile 
1               5                   10                  15      


Asn Gln Ile Pro Glu Asn Leu Gln Asp Thr Leu Ile Ala Val Phe Ser 
            20                  25                  30          


Val Ser Asp Pro Asp Ser Gly Asp Asn Gly Arg Met Val Cys Ser Ile 
        35                  40                  45              


Gln Asp Asp Leu Pro Phe Phe Leu Lys Pro Ser Val Glu Asn Phe Tyr 
    50                  55                  60                  


Thr Leu Val Ile Ser Thr Ala Leu Asp Arg Glu Thr Arg Ser Glu Tyr 
65                  70                  75                  80  


Asn Ile Thr Ile Thr Val Thr Asp Phe Gly Thr Cys Pro Arg Ala Thr 
                85                  90                  95      


Ser Thr Arg Cys Val 
            100     

<210>  2248
<211>  410
<212>  DNA
<213>  Homo sapiens

<400>  2248
caggcccagg ccgacttgct caccgtctac ctgatggtgg acgtgagcgg caccgggacc     60

ctgtcccaga gctaccagta cgaggtgtgt ctgactggag gctccgggac aaatgagttc    120

aagttcctga agccaattat ccccaacttc gttgctcagg gtgcagagag ggttagcgag    180

gcaaatccca gtttcaggaa gagctttgaa ttcacttaag tgttaataag gatctactga    240

ggctagtctc gtttaatttg tggaaagtcc ttttttactg ctttgcccat tggaggtgtc    300

tccttttatt agaaagtaac catcttattc caattctatg catgttactg gtatttataa    360

atgtatgagt ttttttgcgg tataataaat gtaaattttc tttgtattct               410


<210>  2249
<211>  61
<212>  PRT
<213>  Homo sapiens

<400>  2249


Met Val Asp Val Ser Gly Thr Gly Thr Leu Ser Gln Ser Tyr Gln Tyr 
1               5                   10                  15      


Glu Val Cys Leu Thr Gly Gly Ser Gly Thr Asn Glu Phe Lys Phe Leu 
            20                  25                  30          


Lys Pro Ile Ile Pro Asn Phe Val Ala Gln Gly Ala Glu Arg Val Ser 
        35                  40                  45              


Glu Ala Asn Pro Ser Phe Arg Lys Ser Phe Glu Phe Thr 
    50                  55                  60      

<210>  2250
<211>  584
<212>  DNA
<213>  Homo sapiens

<400>  2250
agtccagcga cctgagggca aacaggtggc cgttgtccgc gttgatggag accagggaag     60

agaggggcag ccacagaata gcgtcttgac tcggacccag ccagagaccc tcccagaaaa    120

acaaagagaa gcaagacttg cctttgtcta agaaatcgct ctcctcccgc ctccattgca    180

ctttccgtca cgctcttcca gggaatgtcg ccaagctgaa cctcagacag agctgggaaa    240

cagtcttttg ccccacaacc tttgtagacg gcctagtgaa taagcctttc cagaggctca    300

gacttgctgg ctcaaaaatc tgcctgggct ctcaaccgct ggtttaccac actggatccg    360

tgcgtcaccg agcatgcaca atgcctgtgg tttaattcgc cttcttagtc aacagcgcca    420

ccatgcgttc gcttgcagtt acaaaatctt ggagaaggtg tttttatttt gctttatcga    480

ttattcttat caaccctagt tgacgctact ggaggagttt ctcatgttat atgaattaaa    540

taaatgcaat ctagggaaat aaaatgcact tttatctacg agca                     584


<210>  2251
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  2251


Met His Asn Ala Cys Gly Leu Ile Arg Leu Leu Ser Gln Gln Arg His 
1               5                   10                  15      


His Ala Phe Ala Cys Ser Tyr Lys Ile Leu Glu Lys Val Phe Leu Phe 
            20                  25                  30          


Cys Phe Ile Asp Tyr Ser Tyr Gln Pro 
        35                  40      

<210>  2252
<211>  444
<212>  DNA
<213>  Homo sapiens

<400>  2252
tgttctatcg actaaggatt ctcgattgaa atacaaaaca ttcagagcca cacaactact     60

ttccagtact gttaatgaaa cctaagccat ccctggattt gatattttgc tcccacaacc    120

tttgtagacg gcctagtgaa taagcctttc cagaggctca gacttgctgg ctcaaaaatc    180

tgcctgggct ctcaaccgct ggtttaccac actggatccg tgcgtcaccg agcatgcaca    240

atgcctgtgg tttaattcgc cttcttagtc aacagcgcca ccatgcgttc gcttgcagtt    300

acaaaatctt ggagaaggtg tttttatttt gctttatcga ttattcttat caaccctagt    360

tgacgctact ggaggagttt ctcatgttat atgaattaaa taaatgcaat ctagggaaat    420

aaaatgcact tttatctacg agca                                           444


<210>  2253
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  2253


Met His Asn Ala Cys Gly Leu Ile Arg Leu Leu Ser Gln Gln Arg His 
1               5                   10                  15      


His Ala Phe Ala Cys Ser Tyr Lys Ile Leu Glu Lys Val Phe Leu Phe 
            20                  25                  30          


Cys Phe Ile Asp Tyr Ser Tyr Gln Pro 
        35                  40      

<210>  2254
<211>  3575
<212>  DNA
<213>  Homo sapiens

<400>  2254
tagataaaag tgcattttat ttccctagat tgcatttatt taattcatat aacatgagaa     60

actcctccag tagcgtcaac tagggttgat aagaataatc gataaagcaa aataaaaaca    120

ccttctccaa gattttgtaa ctgcaagcga acgcatggtg gcgctgttga ctaagaaggc    180

gaattaaacc acaggcattg tgcatgctcg gtgacgcacg gatccagtgt ggtaaaccag    240

cggttgagag cccaggcaga tttttgagcc agcaagtctg agcctctgga aaggcttatt    300

cactaggccg tctacaaagg ttgtggggca aaagactgtt tcccagctct gtctgaggtt    360

cagcttggcg acattccctg gaagagcgtg acggaaagtg caatggaggc gggaggagag    420

cgatttctta gacaaaggca agtcttgctt ctctttgttt ttctgggagg gtctctggct    480

gggtccgagt caagacgcta ttctgtggct gaggaaaaag agaagggctt tttaatagcc    540

aacctagcaa aggatctggg actaagggta gaggaactgg ccgcgagggg ggcccaagtt    600

gtgtccaaag ggaacaaaca gcattttcag ctcagtcatc agacaggtga tttgctcctg    660

aatgagaaat tggaccggga ggagctatgc ggccccacag aaccatgcat actacatttt    720

cagatattac tgcaaaaccc tttgcaattc gttacaaacg agctccgtat catagatgta    780

aatgaccatt ctccggtatt ctttgaaaat gaaatgcatc tgaaaatcct agaaagcact    840

ctgccaggaa cagtaattcc tttgggaaat gctgaggact tggatgtggg aagaaacagc    900

ctccaaaact acactatcac tccgaattcc cacttccacg tactcactcg cagtcgtagg    960

gacggaagga agtacccgga actagtactg gataaagcgc tcgatcggga ggagcagccg   1020

gaactcagct taacgctcac cgcgctggac ggcggctctc cccctcggtc tgggacagcc   1080

cagataaaca tccaggtctt agatataaac gacaatgcac cagaatttgc acagccgctc   1140

tatgaggttg cagttctaga gaataccccc gttaactctg tcattgtcac tgtctcggct   1200

tctgacttag atacaggaag ttttgggaca atatcatatg cattttttca tgcttctgaa   1260

gaaattcgca aaacttttca gctaaatcca attactggtg atatgcaact ggtcaaatat   1320

ttgaattttg aagcgattaa tagttatgaa gtcgacatcg aggccaagga tggcggaggc   1380

ctatccggaa agtctacagt catagtccag gtggttgatg tcaacgacaa cccaccggaa   1440

ctgaccttgt cttcagtaaa cagccctatt cctgagaact cgggagagac tgtactggct   1500

gttttcagtg tttctgatct agactctgga gacaacggaa gagtgatgtg ttccattgag   1560

aacaatctcc ccttcttcct gaaaccatct gtagagaatt tttacaccct agtgtcagaa   1620

ggcgcgctgg acagagagac cagatccgag tacaacatta ccatcactat cactgacctg   1680

gggacaccca ggctgaaaac caagtacaac ataaccgtgc tggtctccga cgtcaatgac   1740

aacgcccccg ccttcaccca aatctcctac accctgttcg tccgcgagaa caacagcccc   1800

gccctgcaca tcggcagtgt cagcgccaca gacagagact caggcaccaa cgcccaggta   1860

acctactcgc tgctgccgcc ccaggacccg cacctgcccc tctcttccct ggtctccatc   1920

aacgcggaca acggccacct gtttgccctc aggtcgctgg actacgaggc cctgcaggcg   1980

ttcgagttcc gcgtgggcgc cacagaccgt ggctccccgg ctttgagcag cgaggcgctg   2040

gtgcgcgtgc tggtgctgga cgccaacgac aactcgccct tcgtgctgta cccgctgcag   2100

aacggctccg cgccctgcac cgagctggtg ccccgggcgg ctgagccggg ctacctggtg   2160

accaaggtgg tggcggtgga cggcgactcg ggccagaacg cctggctgtc gtaccagctg   2220

ctcaaggcca cggagcccgg gctgttcggc gtgtgggcgc acaatggcga agtgcgcacc   2280

gccaggctgc tgagcgagcg cgacgcggcc aagcacaggc tggtggtgct ggtcaaggac   2340

aatggcgagc ctccgcgctc ggccaccgcc acgctgcatg tgctcctggt ggacggcttc   2400

tcccagccct acctgcctct cccggaggcg gcaccggccc aggcccaggc cgacttgctc   2460

accgtctacc tggtggtggc attggcctcg gtgtcttcgc tcttcctctt ttcggtgctc   2520

ctgttcgtgg cggtgcggct gtgcaggagg agcagggcgg cctcggtggg tcgctgctcg   2580

gtgcccgagg gcccctttcc agggcagatg gtggacgtga gcggcaccgg gaccctgtcc   2640

cagagctacc agtacgaggt gtgtctgact ggaggctccg ggacaaatga gttcaagttc   2700

ctgaagccaa ttatccccaa cttcgttgct cagggtgcag agagggttag cgaggcaaat   2760

cccagtttca ggaagagctt tgaattcagt taagtgttaa taaggatcta ctgagcctcg   2820

tcttagttaa tctgtggaaa gtcctttttt actgctttgt ccattggaga ggtctttttt   2880

ggtctggttc aaggcaagta gcaagaatag agcaaaatat caaatccagg gatggcttag   2940

gtttcattaa cagtactgga aagtagttgt gtggctctga atgttttgta tttcaatcga   3000

gaatccttag tcgatagaac attttgttta tatattgatt ctactttttc tgtagttaat   3060

ccttgcatat tctcctttca tcctggcttg ccaacgcagt cttaattccg cctttttttt   3120

ttctaatggg gagcaaaaag aaattcactg tcttttaata gtgatttcaa atagcttatt   3180

aaaataactc cattcaaatt ttacattata aagcaatgta gagagagttc caaaccacca   3240

attttataat ttcccttgtt gaatatattc atataatgtg ttctataata tgcccaaagc   3300

agctttgtct atagttaaca aagttttaag gatagacaag aatgtgtttt ctttaataaa   3360

tagtaatata tcatcttttt agggatatag tactcaaatg aaagtaattt agttcatttt   3420

ctgtgttgac atttgcaatt aatatttcaa tattttatgt gcttatattg gccaaaatat   3480

ggacacaaat atagactaat atgggtaatt accctttggt ttatctaaag tgtgttcatg   3540

atgactgagg aaaaaaatta aacctatgcc attta                              3575


<210>  2255
<211>  796
<212>  PRT
<213>  Homo sapiens

<400>  2255


Met Glu Ala Gly Gly Glu Arg Phe Leu Arg Gln Arg Gln Val Leu Leu 
1               5                   10                  15      


Leu Phe Val Phe Leu Gly Gly Ser Leu Ala Gly Ser Glu Ser Arg Arg 
            20                  25                  30          


Tyr Ser Val Ala Glu Glu Lys Glu Lys Gly Phe Leu Ile Ala Asn Leu 
        35                  40                  45              


Ala Lys Asp Leu Gly Leu Arg Val Glu Glu Leu Ala Ala Arg Gly Ala 
    50                  55                  60                  


Gln Val Val Ser Lys Gly Asn Lys Gln His Phe Gln Leu Ser His Gln 
65                  70                  75                  80  


Thr Gly Asp Leu Leu Leu Asn Glu Lys Leu Asp Arg Glu Glu Leu Cys 
                85                  90                  95      


Gly Pro Thr Glu Pro Cys Ile Leu His Phe Gln Ile Leu Leu Gln Asn 
            100                 105                 110         


Pro Leu Gln Phe Val Thr Asn Glu Leu Arg Ile Ile Asp Val Asn Asp 
        115                 120                 125             


His Ser Pro Val Phe Phe Glu Asn Glu Met His Leu Lys Ile Leu Glu 
    130                 135                 140                 


Ser Thr Leu Pro Gly Thr Val Ile Pro Leu Gly Asn Ala Glu Asp Leu 
145                 150                 155                 160 


Asp Val Gly Arg Asn Ser Leu Gln Asn Tyr Thr Ile Thr Pro Asn Ser 
                165                 170                 175     


His Phe His Val Leu Thr Arg Ser Arg Arg Asp Gly Arg Lys Tyr Pro 
            180                 185                 190         


Glu Leu Val Leu Asp Lys Ala Leu Asp Arg Glu Glu Gln Pro Glu Leu 
        195                 200                 205             


Ser Leu Thr Leu Thr Ala Leu Asp Gly Gly Ser Pro Pro Arg Ser Gly 
    210                 215                 220                 


Thr Ala Gln Ile Asn Ile Gln Val Leu Asp Ile Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Glu Phe Ala Gln Pro Leu Tyr Glu Val Ala Val Leu Glu Asn Thr Pro 
                245                 250                 255     


Val Asn Ser Val Ile Val Thr Val Ser Ala Ser Asp Leu Asp Thr Gly 
            260                 265                 270         


Ser Phe Gly Thr Ile Ser Tyr Ala Phe Phe His Ala Ser Glu Glu Ile 
        275                 280                 285             


Arg Lys Thr Phe Gln Leu Asn Pro Ile Thr Gly Asp Met Gln Leu Val 
    290                 295                 300                 


Lys Tyr Leu Asn Phe Glu Ala Ile Asn Ser Tyr Glu Val Asp Ile Glu 
305                 310                 315                 320 


Ala Lys Asp Gly Gly Gly Leu Ser Gly Lys Ser Thr Val Ile Val Gln 
                325                 330                 335     


Val Val Asp Val Asn Asp Asn Pro Pro Glu Leu Thr Leu Ser Ser Val 
            340                 345                 350         


Asn Ser Pro Ile Pro Glu Asn Ser Gly Glu Thr Val Leu Ala Val Phe 
        355                 360                 365             


Ser Val Ser Asp Leu Asp Ser Gly Asp Asn Gly Arg Val Met Cys Ser 
    370                 375                 380                 


Ile Glu Asn Asn Leu Pro Phe Phe Leu Lys Pro Ser Val Glu Asn Phe 
385                 390                 395                 400 


Tyr Thr Leu Val Ser Glu Gly Ala Leu Asp Arg Glu Thr Arg Ser Glu 
                405                 410                 415     


Tyr Asn Ile Thr Ile Thr Ile Thr Asp Leu Gly Thr Pro Arg Leu Lys 
            420                 425                 430         


Thr Lys Tyr Asn Ile Thr Val Leu Val Ser Asp Val Asn Asp Asn Ala 
        435                 440                 445             


Pro Ala Phe Thr Gln Ile Ser Tyr Thr Leu Phe Val Arg Glu Asn Asn 
    450                 455                 460                 


Ser Pro Ala Leu His Ile Gly Ser Val Ser Ala Thr Asp Arg Asp Ser 
465                 470                 475                 480 


Gly Thr Asn Ala Gln Val Thr Tyr Ser Leu Leu Pro Pro Gln Asp Pro 
                485                 490                 495     


His Leu Pro Leu Ser Ser Leu Val Ser Ile Asn Ala Asp Asn Gly His 
            500                 505                 510         


Leu Phe Ala Leu Arg Ser Leu Asp Tyr Glu Ala Leu Gln Ala Phe Glu 
        515                 520                 525             


Phe Arg Val Gly Ala Thr Asp Arg Gly Ser Pro Ala Leu Ser Ser Glu 
    530                 535                 540                 


Ala Leu Val Arg Val Leu Val Leu Asp Ala Asn Asp Asn Ser Pro Phe 
545                 550                 555                 560 


Val Leu Tyr Pro Leu Gln Asn Gly Ser Ala Pro Cys Thr Glu Leu Val 
                565                 570                 575     


Pro Arg Ala Ala Glu Pro Gly Tyr Leu Val Thr Lys Val Val Ala Val 
            580                 585                 590         


Asp Gly Asp Ser Gly Gln Asn Ala Trp Leu Ser Tyr Gln Leu Leu Lys 
        595                 600                 605             


Ala Thr Glu Pro Gly Leu Phe Gly Val Trp Ala His Asn Gly Glu Val 
    610                 615                 620                 


Arg Thr Ala Arg Leu Leu Ser Glu Arg Asp Ala Ala Lys His Arg Leu 
625                 630                 635                 640 


Val Val Leu Val Lys Asp Asn Gly Glu Pro Pro Arg Ser Ala Thr Ala 
                645                 650                 655     


Thr Leu His Val Leu Leu Val Asp Gly Phe Ser Gln Pro Tyr Leu Pro 
            660                 665                 670         


Leu Pro Glu Ala Ala Pro Ala Gln Ala Gln Ala Asp Leu Leu Thr Val 
        675                 680                 685             


Tyr Leu Val Val Ala Leu Ala Ser Val Ser Ser Leu Phe Leu Phe Ser 
    690                 695                 700                 


Val Leu Leu Phe Val Ala Val Arg Leu Cys Arg Arg Ser Arg Ala Ala 
705                 710                 715                 720 


Ser Val Gly Arg Cys Ser Val Pro Glu Gly Pro Phe Pro Gly Gln Met 
                725                 730                 735     


Val Asp Val Ser Gly Thr Gly Thr Leu Ser Gln Ser Tyr Gln Tyr Glu 
            740                 745                 750         


Val Cys Leu Thr Gly Gly Ser Gly Thr Asn Glu Phe Lys Phe Leu Lys 
        755                 760                 765             


Pro Ile Ile Pro Asn Phe Val Ala Gln Gly Ala Glu Arg Val Ser Glu 
    770                 775                 780                 


Ala Asn Pro Ser Phe Arg Lys Ser Phe Glu Phe Ser 
785                 790                 795     

<210>  2256
<211>  162
<212>  DNA
<213>  Homo sapiens

<400>  2256
caggcccagg ccgacttgct caccgtctac ctgatggtgg acgtgagcgg caccgggacc     60

ctgtcccaga gctaccagta cgaggtgtgt ctgactggag gctccgggac aaatgagttc    120

aagttcctga agccaattat ccccaacttc gttgctcagg gt                       162


<210>  2257
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  2257


Met Val Asp Val Ser Gly Thr Gly Thr Leu Ser Gln Ser Tyr Gln Tyr 
1               5                   10                  15      


Glu Val Cys Leu Thr Gly Gly Ser Gly Thr Asn Glu Phe Lys Phe Leu 
            20                  25                  30          


Lys Pro Ile Ile Pro Asn Phe Val Ala Gln 
        35                  40          

<210>  2258
<211>  4037
<212>  DNA
<213>  Homo sapiens

<400>  2258
cttaaaaatg gcttttattt taaaacttcc caaatacgtt gtcttgaagt tgttaatttc     60

tcaatcaaga cgcagggtgg cgctgcaggc taagttgtga ataatgagcc ctaaaaagct    120

cgcgcgtatt cttctgtgtc gctagacgca atcaaaaaca cacggaagaa gcgttacaag    180

cagtgcaggt ttaccaacgg cttggggcag cgatatacta aacaaattta atattaaaag    240

caactgtgtg acgattcctc caagcaagaa attggaattg aatgtctcaa gtctcgttgc    300

ggttgctgag gggattggat atagggacct ggactccaac atgaagaagc tagggagaat    360

tcatccaaac aggcaagtgt tggcctttat tttgatggtg ttcttgtctc aggttcgcct    420

cgagcctatt cgttattctg tgttggagga aacagagagc ggctcctttg tagcccatct    480

ggccaaggat ctgggcctgg gaattgggga actggcctcc cggtcagccc gggtgctgtc    540

tgacgatgac aagcagcgtt tgcagctgga tcgtcagact ggagatttgc ttctgaggga    600

gaaactagac cgggaagagc tctgtggtcc tattgaaccg tgtgtactgc atttccaagt    660

gttcctggaa atgccggtgc aattttttca aggagaatta ttgatccagg acataaatga    720

tcactctcca atattccctg aaagggaagt gctcttgaaa atactagaaa atagccagcc    780

gggtactcta tttccgttgc taatagctga ggatttggat gtgggcagca atggtcttca    840

aaaatacaca atcagcccca attctcattt tcacattctc actcgaaatc atagtgaggg    900

caagaaatac ccagatttgg tgcaggacaa accactggat cgagaggagc agcctgagtt    960

cagcttaacc ctcgtggcgc tggatggtgg gtcaccacct aggtctggca cggtcatggt   1020

tcgaatcctg atcatggaca tcaatgacaa tgctcctgag tttgtgcaca ctccatatgg   1080

ggtgcaggtc ctggaaaaca gccccctaga ctctccaatt gttagggtct tagctagaga   1140

tatagatgct ggaaacttcg ggagtgtttc ttatggctta ttccaagcat cagatgaaat   1200

taaacaaact ttctcaataa atgaagtcac gggagaaata ctgttgaaaa aaaaattgga   1260

tttcgaaaaa attaaatctt accatgtaga aattgaggcc acagatggag gaggcctttc   1320

tggaaaaggc actgtagtca tagaggtggt ggatgtgaat gacaatcccc cagaacttat   1380

catatcttca ctcaccagct ccatcccaga aaatgctcct gagacggtag tctctatctt   1440

ccgaattcga gatagagatt ccggagaaaa tggaaagatg atttgctcta ttccagataa   1500

tctaccgttt attctaaaac caactttgaa gaatttttac accctggtaa cagagagacc   1560

actggaccga gagaccagcg ctgagtacaa catcaccatc gccgtcactg acttggggac   1620

acccaggctg aaaacccagc agaacataac cgtgcaggtc tccgacgtca atgacaacgc   1680

ccccgccttc acccaaacct cctacaccct gttcgtccgc gagaacaaca gccccgccct   1740

gcacatcggc agtgtcagcg ccacagacag agactcgggc accaacgccc aggtcaccta   1800

ctcgctgctg ccgccccagg acccgcacct gcccctcgcc tccctggtct ccatcaacgc   1860

agacaacggc cacctgttcg ccctcaggtc gctggactac gaggccctgc aggcgttcga   1920

gttccgcgtg ggcgcctcag accgcggttc tccggctttg agcagcgagg cgctggtgcg   1980

cgtgctggtg ctggacacca acgacaactc gcccttcgtg ctgtacccgc tgcagaatgg   2040

ctccgcgccc tgcaccgagc tggtgccccg ggcggccgag ccgggctacc tggtgaccaa   2100

ggtggtggcg gtggacggcg actcgggcca gaacgcctgg ctgtcgtacc agctgctcaa   2160

ggccacggag cctgggctgt tcggcgtgtg ggcgcacaat ggcgaggtgc gcaccgccag   2220

gctgctgagc gagcgcgacg cagccaagca caggctcgtg gtgcttgtca aggacaatgg   2280

cgagcctccg cgctcggcca ccgccacgct gcacgtgctc ctggtggatg gcttctccca   2340

gccctacctg cctctccctg aggcggcccc ggcccaggcc caggccgact ctctcaccgt   2400

ctacctggtg gtggcgttgg cctcggtgtc gtcgctcttc ctcttctcgg tgctcctgtt   2460

cgtggcggtg cggctgtgca ggaggagcag ggcggcctcg gtgggtcgct gctcggtgcc   2520

cgagggcccc tttccagggc atctggtgga cgtaagcggc accgggaccc tgtcccagag   2580

ctaccagtac gaggtgtgtc tgacaggaga ctctgggact ggtgagttca agttcctgaa   2640

gccaatattt cctaatctct tggttcagga caccgggagg gaagttaagg aaaaccccaa   2700

gttcagaaat agcttggtat tcagttaagt attgtattta gttcagtgaa ccgcccgtta   2760

gttttgtcaa acttcccact gcaatgcctt tatttaaaaa aattgtctac ttatctaaat   2820

attcatacca caatttcaaa cctactcatg tccctgataa agctaaattt gtcccttttt   2880

tattgttatt aattgcactt aacattttta gttatactgg atattgagta tggattttct   2940

ctatatttga tctattggtg attaatcttt ttgtaatcat aaattactca attaggataa   3000

aaataaatta tgttttaatg aaattcttaa attaacatct ttttaatgga acatttaagt   3060

gaatatatga atattgaatt tctaaatatt tgttgtgcct gtctttacca tgtaacttaa   3120

tgtttgcaag gccagagtgt ttgaaagttt tgtatttaac tttataatta ccttgtcctt   3180

tctggttgac tatactaggc taagccctct taatagccat gagtgtaaaa tttagtttac   3240

tcatttttca caaattgtat ataaacatgc acttcactac attggtaata cactaaaatt   3300

gtggtccttt tcctcttgtg accaccacat gtctagtgat tattttgttt atttggttgc   3360

tacttaccta gcacattgta atgttccatg aatgctaata ttaaattttg taaaaataac   3420

ttatttataa ataattttta aagagaaaaa tctcatataa tttgtcataa cctttcaata   3480

aataaaactg ttaaatcatg gcctgatatc atcttaaaaa aaaatctcag aatctgaaat   3540

aagccctaaa tttctcccca aaatcaagac tcttgagagc atcataggtc tccttgtgct   3600

accttttact ccctataaat agaaatccaa gtatacttta atatgtgtat attttttggt   3660

tttcctacag cttctcccca tctttcaaaa gaatcacgaa atttcttctg caccttggct   3720

attctgttta aatctgataa tcagttgatc tcaggttttt cactgtacat tactttgcag   3780

atatggacag cctttacaaa aataattttt aaatgcttaa ttattttaat ttgttcttta   3840

aggtaacctt cagttatttt gaattaattt aacttctcaa ttatgccaaa gttgcacttg   3900

catgaaataa atattatttt gtccttgtat agactggaac agtaataaat ttatctgaat   3960

taaaattgtt ttatgctgtg atcagtaagc ccagtaagct aggtaaagtt gtatggatat   4020

aactatagta cacctct                                                  4037


<210>  2259
<211>  795
<212>  PRT
<213>  Homo sapiens

<400>  2259


Met Lys Lys Leu Gly Arg Ile His Pro Asn Arg Gln Val Leu Ala Phe 
1               5                   10                  15      


Ile Leu Met Val Phe Leu Ser Gln Val Arg Leu Glu Pro Ile Arg Tyr 
            20                  25                  30          


Ser Val Leu Glu Glu Thr Glu Ser Gly Ser Phe Val Ala His Leu Ala 
        35                  40                  45              


Lys Asp Leu Gly Leu Gly Ile Gly Glu Leu Ala Ser Arg Ser Ala Arg 
    50                  55                  60                  


Val Leu Ser Asp Asp Asp Lys Gln Arg Leu Gln Leu Asp Arg Gln Thr 
65                  70                  75                  80  


Gly Asp Leu Leu Leu Arg Glu Lys Leu Asp Arg Glu Glu Leu Cys Gly 
                85                  90                  95      


Pro Ile Glu Pro Cys Val Leu His Phe Gln Val Phe Leu Glu Met Pro 
            100                 105                 110         


Val Gln Phe Phe Gln Gly Glu Leu Leu Ile Gln Asp Ile Asn Asp His 
        115                 120                 125             


Ser Pro Ile Phe Pro Glu Arg Glu Val Leu Leu Lys Ile Leu Glu Asn 
    130                 135                 140                 


Ser Gln Pro Gly Thr Leu Phe Pro Leu Leu Ile Ala Glu Asp Leu Asp 
145                 150                 155                 160 


Val Gly Ser Asn Gly Leu Gln Lys Tyr Thr Ile Ser Pro Asn Ser His 
                165                 170                 175     


Phe His Ile Leu Thr Arg Asn His Ser Glu Gly Lys Lys Tyr Pro Asp 
            180                 185                 190         


Leu Val Gln Asp Lys Pro Leu Asp Arg Glu Glu Gln Pro Glu Phe Ser 
        195                 200                 205             


Leu Thr Leu Val Ala Leu Asp Gly Gly Ser Pro Pro Arg Ser Gly Thr 
    210                 215                 220                 


Val Met Val Arg Ile Leu Ile Met Asp Ile Asn Asp Asn Ala Pro Glu 
225                 230                 235                 240 


Phe Val His Thr Pro Tyr Gly Val Gln Val Leu Glu Asn Ser Pro Leu 
                245                 250                 255     


Asp Ser Pro Ile Val Arg Val Leu Ala Arg Asp Ile Asp Ala Gly Asn 
            260                 265                 270         


Phe Gly Ser Val Ser Tyr Gly Leu Phe Gln Ala Ser Asp Glu Ile Lys 
        275                 280                 285             


Gln Thr Phe Ser Ile Asn Glu Val Thr Gly Glu Ile Leu Leu Lys Lys 
    290                 295                 300                 


Lys Leu Asp Phe Glu Lys Ile Lys Ser Tyr His Val Glu Ile Glu Ala 
305                 310                 315                 320 


Thr Asp Gly Gly Gly Leu Ser Gly Lys Gly Thr Val Val Ile Glu Val 
                325                 330                 335     


Val Asp Val Asn Asp Asn Pro Pro Glu Leu Ile Ile Ser Ser Leu Thr 
            340                 345                 350         


Ser Ser Ile Pro Glu Asn Ala Pro Glu Thr Val Val Ser Ile Phe Arg 
        355                 360                 365             


Ile Arg Asp Arg Asp Ser Gly Glu Asn Gly Lys Met Ile Cys Ser Ile 
    370                 375                 380                 


Pro Asp Asn Leu Pro Phe Ile Leu Lys Pro Thr Leu Lys Asn Phe Tyr 
385                 390                 395                 400 


Thr Leu Val Thr Glu Arg Pro Leu Asp Arg Glu Thr Ser Ala Glu Tyr 
                405                 410                 415     


Asn Ile Thr Ile Ala Val Thr Asp Leu Gly Thr Pro Arg Leu Lys Thr 
            420                 425                 430         


Gln Gln Asn Ile Thr Val Gln Val Ser Asp Val Asn Asp Asn Ala Pro 
        435                 440                 445             


Ala Phe Thr Gln Thr Ser Tyr Thr Leu Phe Val Arg Glu Asn Asn Ser 
    450                 455                 460                 


Pro Ala Leu His Ile Gly Ser Val Ser Ala Thr Asp Arg Asp Ser Gly 
465                 470                 475                 480 


Thr Asn Ala Gln Val Thr Tyr Ser Leu Leu Pro Pro Gln Asp Pro His 
                485                 490                 495     


Leu Pro Leu Ala Ser Leu Val Ser Ile Asn Ala Asp Asn Gly His Leu 
            500                 505                 510         


Phe Ala Leu Arg Ser Leu Asp Tyr Glu Ala Leu Gln Ala Phe Glu Phe 
        515                 520                 525             


Arg Val Gly Ala Ser Asp Arg Gly Ser Pro Ala Leu Ser Ser Glu Ala 
    530                 535                 540                 


Leu Val Arg Val Leu Val Leu Asp Thr Asn Asp Asn Ser Pro Phe Val 
545                 550                 555                 560 


Leu Tyr Pro Leu Gln Asn Gly Ser Ala Pro Cys Thr Glu Leu Val Pro 
                565                 570                 575     


Arg Ala Ala Glu Pro Gly Tyr Leu Val Thr Lys Val Val Ala Val Asp 
            580                 585                 590         


Gly Asp Ser Gly Gln Asn Ala Trp Leu Ser Tyr Gln Leu Leu Lys Ala 
        595                 600                 605             


Thr Glu Pro Gly Leu Phe Gly Val Trp Ala His Asn Gly Glu Val Arg 
    610                 615                 620                 


Thr Ala Arg Leu Leu Ser Glu Arg Asp Ala Ala Lys His Arg Leu Val 
625                 630                 635                 640 


Val Leu Val Lys Asp Asn Gly Glu Pro Pro Arg Ser Ala Thr Ala Thr 
                645                 650                 655     


Leu His Val Leu Leu Val Asp Gly Phe Ser Gln Pro Tyr Leu Pro Leu 
            660                 665                 670         


Pro Glu Ala Ala Pro Ala Gln Ala Gln Ala Asp Ser Leu Thr Val Tyr 
        675                 680                 685             


Leu Val Val Ala Leu Ala Ser Val Ser Ser Leu Phe Leu Phe Ser Val 
    690                 695                 700                 


Leu Leu Phe Val Ala Val Arg Leu Cys Arg Arg Ser Arg Ala Ala Ser 
705                 710                 715                 720 


Val Gly Arg Cys Ser Val Pro Glu Gly Pro Phe Pro Gly His Leu Val 
                725                 730                 735     


Asp Val Ser Gly Thr Gly Thr Leu Ser Gln Ser Tyr Gln Tyr Glu Val 
            740                 745                 750         


Cys Leu Thr Gly Asp Ser Gly Thr Gly Glu Phe Lys Phe Leu Lys Pro 
        755                 760                 765             


Ile Phe Pro Asn Leu Leu Val Gln Asp Thr Gly Arg Glu Val Lys Glu 
    770                 775                 780                 


Asn Pro Lys Phe Arg Asn Ser Leu Val Phe Ser 
785                 790                 795 

<210>  2260
<211>  527
<212>  DNA
<213>  Homo sapiens

<400>  2260
acacggaaga agcgttacaa gcagtgcagg tttaccaacg gcttggggca gcgatatact     60

aaacaaattt aatattaaaa gcaactgtgt gacgattcct ccaagcaaga aattggaatt    120

gaatgtctca agtctcgttg cggttgctga ggggattgga tatagggacc tggactccaa    180

catgaagaag ctagggagaa ttcatccaaa cagataatct accgtttatt ctaaaaccaa    240

ctttgaagaa tttttacacc ctggtaacag agagaccact ggaccgagag accagcgctg    300

agtacaacat caccatcgcc gtcactgact tggggacacc caggctgaaa acccagcaga    360

acataaccgt gcaggtctcc gacgtcaatg acaacgcccc cgccttcacc caaacctcct    420

acaccctgtt cgtccgcgag aacaacagcc ccgccctgca catcggcagt gtcagcgcca    480

cagacagaga ctcgggcacc aacgcccagg tcacctactc gctgctg                  527


<210>  2261
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  2261


Met Thr Thr Pro Pro Pro Ser Pro Lys Pro Pro Thr Pro Cys Ser Ser 
1               5                   10                  15      


Ala Arg Thr Thr Ala Pro Pro Cys Thr Ser Ala Val Ser Ala Pro Gln 
            20                  25                  30          


Thr Glu Thr Arg Ala Pro Thr Pro Arg Ser Pro Thr Arg 
        35                  40                  45  

<210>  2262
<211>  1161
<212>  DNA
<213>  Homo sapiens

<400>  2262
aagagtgtgg atagtgggct ctgcggataa ctcagacgcc attaagctgg ggaatccaaa     60

ctctaaaaga aggacgcatt ttaggtaaga tctagtggct agatcttcag ggtgggcttc    120

gttcttgtgg aaatcagtca agaaagatcg gattcgcggt tatttatgca aatcatctgg    180

gtggattgtg tacggagtta aactgcgcct tctggaccgg gtctgaacaa tggagactgc    240

gctagcaaaa acgccacaga aaaggcaagt tatgtttctt gctatattgt tgcttttgtg    300

ggaggctggc tctgaggcag ttaggtattc cataccagaa gaaacagaaa gtggctattc    360

tgtggccaac ctggcaaaag acctgggtct tggggtgggg gaactggcca ctcggggcgc    420

gcgaatgcat tacaaaggaa acaaagagct cttgcagctt gatataaaga ccggcaattt    480

gcttctatat gaaaaactag accgggaggt gatgtgcggg gcgacagaac cctgtatatt    540

gcatttccag ctcttactag aaaatccagt gcagtttttt caaactgatc tgcagctcac    600

agatataaat gaccatgccc cagagttccc agagaaggaa atgctcctaa aaatcccaga    660

gagcacccag ccagggactg tgtttccctt aaaaatagcc caggactttg acataggtag    720

caacactgtt cagaactaca caatcagccc aaattcacac tttcatgttg ctacgcataa    780

tcgcggagat ggcagaaaat acccagagct ggtgctggac aaagcgcttc cggaatagct    840

ttggattaaa ttagagatct cgtgatgacg cgttgttttc tgccatttat cccaaacttt    900

ttcagatcta gaattcgaga gtgtcatgga caaaaatttc accttgagat tgagctttta    960

tttccctttt taatggattt gtctgttgaa cttcatgctg tccaagtgtt gaaaagtcaa   1020

ttttatttca ttgcatttat ttacatagtg tcattccaaa tccatgcatg ctgttgattt   1080

tcctgagatt tttttctctt cttgttggta tttgttgtga taaaccacct taataaaatc   1140

aagtattaat tttattttct a                                             1161


<210>  2263
<211>  202
<212>  PRT
<213>  Homo sapiens

<400>  2263


Met Glu Thr Ala Leu Ala Lys Thr Pro Gln Lys Arg Gln Val Met Phe 
1               5                   10                  15      


Leu Ala Ile Leu Leu Leu Leu Trp Glu Ala Gly Ser Glu Ala Val Arg 
            20                  25                  30          


Tyr Ser Ile Pro Glu Glu Thr Glu Ser Gly Tyr Ser Val Ala Asn Leu 
        35                  40                  45              


Ala Lys Asp Leu Gly Leu Gly Val Gly Glu Leu Ala Thr Arg Gly Ala 
    50                  55                  60                  


Arg Met His Tyr Lys Gly Asn Lys Glu Leu Leu Gln Leu Asp Ile Lys 
65                  70                  75                  80  


Thr Gly Asn Leu Leu Leu Tyr Glu Lys Leu Asp Arg Glu Val Met Cys 
                85                  90                  95      


Gly Ala Thr Glu Pro Cys Ile Leu His Phe Gln Leu Leu Leu Glu Asn 
            100                 105                 110         


Pro Val Gln Phe Phe Gln Thr Asp Leu Gln Leu Thr Asp Ile Asn Asp 
        115                 120                 125             


His Ala Pro Glu Phe Pro Glu Lys Glu Met Leu Leu Lys Ile Pro Glu 
    130                 135                 140                 


Ser Thr Gln Pro Gly Thr Val Phe Pro Leu Lys Ile Ala Gln Asp Phe 
145                 150                 155                 160 


Asp Ile Gly Ser Asn Thr Val Gln Asn Tyr Thr Ile Ser Pro Asn Ser 
                165                 170                 175     


His Phe His Val Ala Thr His Asn Arg Gly Asp Gly Arg Lys Tyr Pro 
            180                 185                 190         


Glu Leu Val Leu Asp Lys Ala Leu Pro Glu 
        195                 200         

<210>  2264
<211>  2913
<212>  DNA
<213>  Homo sapiens

<400>  2264
agtgggctct gcggataact cagacgccat taagctgggg aatccaaact ctaaaagaag     60

gacgcatttt aggtaagatc tagtggctag atcttcaggg tgggcttcgt tcttgtggaa    120

atcagtcaag aaagatcgga ttcgcggtta tttatgcaaa tcatctgggt ggattgtgta    180

cggagttaaa ctgcgccttc tggaccgggt ctgaacaatg gagactgcgc tagcaaaaac    240

gccacagaaa aggcaagtta tgtttcttgc tatattgttg cttttgtggg aggctggctc    300

tgaggcagtt aggtattcca taccagaaga aacagaaagt ggctattctg tggccaacct    360

ggcaaaagac ctgggtcttg gggtggggga actggccact cggggcgcgc gaatgcatta    420

caaaggaaac aaagagctct tgcagcttga tataaagacc ggcaatttgc ttctatatga    480

aaaactagac cgggaggtga tgtgcggggc gacagaaccc tgtatattgc atttccagct    540

cttactagaa aatccagtgc agttttttca aactgatctg cagctcacag atataaatga    600

ccatgcccca gagttcccag agaaggaaat gctcctaaaa atcccagaga gcacccagcc    660

agggactgtg tttcccttaa aaatagccca ggactttgac ataggtagca acactgttca    720

gaactacaca atcagcccaa attcacactt tcatgttgct acgcataatc gcggagatgg    780

cagaaaatac ccagagctgg tgctggacaa agcgctggac cgggaggagc ggcctgagct    840

cagcttaaca ctcactgcac tggacggtgg ggctccgccc aggtccggga ccaccacaat    900

tcgcattgtc gtcttggata ataatgacaa cgcccccgaa tttttacaat cattctatga    960

ggtacaggtg cccgagaaca gcccccttaa ctccttagtt gtcgttgtct ccgctcgaga   1020

tttagatgca ggagcatatg ggagtgtagc ctatgctcta ttccaaggcg atgaagttac   1080

tcaaccattt gtaatagacg agaaaacagc agaaattcgc ctgaaaaggg cattggattt   1140

cgaggcaact ccatattata acgtggaaat tgtagccaca gatggtgggg gcctttcagg   1200

aaaatgcact gtggctatag aagtggtgga tgtgaatgac aacgcccctg aactcaccat   1260

gtctacgctc tccagcccta ccccagaaaa tgccccggaa actgtagttg ccgttttcag   1320

tgtttctgat ccagactccg gggacaacgg taggatgatt tgctccatcc agaatgatct   1380

cccctttctt ttgaagccca cattaaaaaa cttttacacc ctagtgacac agagaacact   1440

ggacagagag agccaagccg agtacaacat caccatcact gtcaccgaca tggggacacc   1500

caggctgaaa accgagcaca acataacggt cctggtctcc gacgtcaatg acaacgcccc   1560

cgccttcacc caaacctcct acaccctgtt cgtccgagag aacaacagcc ccgccctgca   1620

catcggcagt gtcagcgcca cagacagaga ctcaggcacc aacgcccagg tcacctactc   1680

gctgctgccg ccccagaacc cacacctgcg cctcgcctcc ctggtctcca tcaacgcgga   1740

caacggccac ctgtttgccc tcaggtcgct ggactacgag gccctgcagg cgttcgagtt   1800

ccgcgtggga gccacagacc gcggctcccc ggcgctgagc agcgaggcgc tggtgcgcgt   1860

gctggtgctg gacgccaacg acaactcgcc cttcgtgctg tatccgctgc agaacggctc   1920

ggcgccttgc accgagctgg tgccccgggc ggccgagccg ggctacctgg tgaccaaggt   1980

ggtggcggtg gacggcgact cgggccagaa cgcctggctg tcgtaccagc tgctcaaggc   2040

cacggagccc gggctgttca gcatgtgggc gcacaatggc gaggtgcgca ccgccaggct   2100

gctgagcgag cgcgacgcgg ccaagcacag gctggtggtg ctggtcaagg acaatggcga   2160

gcctccgcgc tcggccaccg ccacgctgca cgtgctcctg gtggacggct tctcccagcc   2220

ctacctgccg ctgccggagg cggccccggc ccaggcccag gccgactcgc tcactgtcta   2280

cctggtggtg gcattggcct cggtgtcgtc gctcttcctc ttttcggtgc tcctgttcgt   2340

ggcagtgcgg ctgtgcagga ggagcagggc ggcctcggtc ggtcgctgct cggtgcccga   2400

gggccccttt ccagggcatc tggtggacgt gagcggcacc gggaccctat cccagagcta   2460

ccactacgag gtgtgtttga ccggagactc aggggccggc gagttcaagt tcctgaagcc   2520

gattattcct aaccttttgc cccagggcgc tggtgaagaa atagggaaaa ctgctgcctt   2580

ccggaatagc tttggattaa attagagatc tcgtgatgac gcgttgtttt ctgccattta   2640

tcccaaactt tttcagatct agaattcgag agtgtcatgg acaaaaattt caccttgaga   2700

ttgagctttt atttcccttt ttaatggatt tgtctgttga acttcatgct gtccaagtgt   2760

tgaaaagtca attttatttc attgcattta tttacatagt gtcattccaa atccatgcat   2820

gctgttgatt ttcctgagat ttttttctct tcttgttggt atttgttgtg ataaaccacc   2880

ttaataaaat caagtattaa ttttattttc tat                                2913


<210>  2265
<211>  795
<212>  PRT
<213>  Homo sapiens

<400>  2265


Met Glu Thr Ala Leu Ala Lys Thr Pro Gln Lys Arg Gln Val Met Phe 
1               5                   10                  15      


Leu Ala Ile Leu Leu Leu Leu Trp Glu Ala Gly Ser Glu Ala Val Arg 
            20                  25                  30          


Tyr Ser Ile Pro Glu Glu Thr Glu Ser Gly Tyr Ser Val Ala Asn Leu 
        35                  40                  45              


Ala Lys Asp Leu Gly Leu Gly Val Gly Glu Leu Ala Thr Arg Gly Ala 
    50                  55                  60                  


Arg Met His Tyr Lys Gly Asn Lys Glu Leu Leu Gln Leu Asp Ile Lys 
65                  70                  75                  80  


Thr Gly Asn Leu Leu Leu Tyr Glu Lys Leu Asp Arg Glu Val Met Cys 
                85                  90                  95      


Gly Ala Thr Glu Pro Cys Ile Leu His Phe Gln Leu Leu Leu Glu Asn 
            100                 105                 110         


Pro Val Gln Phe Phe Gln Thr Asp Leu Gln Leu Thr Asp Ile Asn Asp 
        115                 120                 125             


His Ala Pro Glu Phe Pro Glu Lys Glu Met Leu Leu Lys Ile Pro Glu 
    130                 135                 140                 


Ser Thr Gln Pro Gly Thr Val Phe Pro Leu Lys Ile Ala Gln Asp Phe 
145                 150                 155                 160 


Asp Ile Gly Ser Asn Thr Val Gln Asn Tyr Thr Ile Ser Pro Asn Ser 
                165                 170                 175     


His Phe His Val Ala Thr His Asn Arg Gly Asp Gly Arg Lys Tyr Pro 
            180                 185                 190         


Glu Leu Val Leu Asp Lys Ala Leu Asp Arg Glu Glu Arg Pro Glu Leu 
        195                 200                 205             


Ser Leu Thr Leu Thr Ala Leu Asp Gly Gly Ala Pro Pro Arg Ser Gly 
    210                 215                 220                 


Thr Thr Thr Ile Arg Ile Val Val Leu Asp Asn Asn Asp Asn Ala Pro 
225                 230                 235                 240 


Glu Phe Leu Gln Ser Phe Tyr Glu Val Gln Val Pro Glu Asn Ser Pro 
                245                 250                 255     


Leu Asn Ser Leu Val Val Val Val Ser Ala Arg Asp Leu Asp Ala Gly 
            260                 265                 270         


Ala Tyr Gly Ser Val Ala Tyr Ala Leu Phe Gln Gly Asp Glu Val Thr 
        275                 280                 285             


Gln Pro Phe Val Ile Asp Glu Lys Thr Ala Glu Ile Arg Leu Lys Arg 
    290                 295                 300                 


Ala Leu Asp Phe Glu Ala Thr Pro Tyr Tyr Asn Val Glu Ile Val Ala 
305                 310                 315                 320 


Thr Asp Gly Gly Gly Leu Ser Gly Lys Cys Thr Val Ala Ile Glu Val 
                325                 330                 335     


Val Asp Val Asn Asp Asn Ala Pro Glu Leu Thr Met Ser Thr Leu Ser 
            340                 345                 350         


Ser Pro Thr Pro Glu Asn Ala Pro Glu Thr Val Val Ala Val Phe Ser 
        355                 360                 365             


Val Ser Asp Pro Asp Ser Gly Asp Asn Gly Arg Met Ile Cys Ser Ile 
    370                 375                 380                 


Gln Asn Asp Leu Pro Phe Leu Leu Lys Pro Thr Leu Lys Asn Phe Tyr 
385                 390                 395                 400 


Thr Leu Val Thr Gln Arg Thr Leu Asp Arg Glu Ser Gln Ala Glu Tyr 
                405                 410                 415     


Asn Ile Thr Ile Thr Val Thr Asp Met Gly Thr Pro Arg Leu Lys Thr 
            420                 425                 430         


Glu His Asn Ile Thr Val Leu Val Ser Asp Val Asn Asp Asn Ala Pro 
        435                 440                 445             


Ala Phe Thr Gln Thr Ser Tyr Thr Leu Phe Val Arg Glu Asn Asn Ser 
    450                 455                 460                 


Pro Ala Leu His Ile Gly Ser Val Ser Ala Thr Asp Arg Asp Ser Gly 
465                 470                 475                 480 


Thr Asn Ala Gln Val Thr Tyr Ser Leu Leu Pro Pro Gln Asn Pro His 
                485                 490                 495     


Leu Arg Leu Ala Ser Leu Val Ser Ile Asn Ala Asp Asn Gly His Leu 
            500                 505                 510         


Phe Ala Leu Arg Ser Leu Asp Tyr Glu Ala Leu Gln Ala Phe Glu Phe 
        515                 520                 525             


Arg Val Gly Ala Thr Asp Arg Gly Ser Pro Ala Leu Ser Ser Glu Ala 
    530                 535                 540                 


Leu Val Arg Val Leu Val Leu Asp Ala Asn Asp Asn Ser Pro Phe Val 
545                 550                 555                 560 


Leu Tyr Pro Leu Gln Asn Gly Ser Ala Pro Cys Thr Glu Leu Val Pro 
                565                 570                 575     


Arg Ala Ala Glu Pro Gly Tyr Leu Val Thr Lys Val Val Ala Val Asp 
            580                 585                 590         


Gly Asp Ser Gly Gln Asn Ala Trp Leu Ser Tyr Gln Leu Leu Lys Ala 
        595                 600                 605             


Thr Glu Pro Gly Leu Phe Ser Met Trp Ala His Asn Gly Glu Val Arg 
    610                 615                 620                 


Thr Ala Arg Leu Leu Ser Glu Arg Asp Ala Ala Lys His Arg Leu Val 
625                 630                 635                 640 


Val Leu Val Lys Asp Asn Gly Glu Pro Pro Arg Ser Ala Thr Ala Thr 
                645                 650                 655     


Leu His Val Leu Leu Val Asp Gly Phe Ser Gln Pro Tyr Leu Pro Leu 
            660                 665                 670         


Pro Glu Ala Ala Pro Ala Gln Ala Gln Ala Asp Ser Leu Thr Val Tyr 
        675                 680                 685             


Leu Val Val Ala Leu Ala Ser Val Ser Ser Leu Phe Leu Phe Ser Val 
    690                 695                 700                 


Leu Leu Phe Val Ala Val Arg Leu Cys Arg Arg Ser Arg Ala Ala Ser 
705                 710                 715                 720 


Val Gly Arg Cys Ser Val Pro Glu Gly Pro Phe Pro Gly His Leu Val 
                725                 730                 735     


Asp Val Ser Gly Thr Gly Thr Leu Ser Gln Ser Tyr His Tyr Glu Val 
            740                 745                 750         


Cys Leu Thr Gly Asp Ser Gly Ala Gly Glu Phe Lys Phe Leu Lys Pro 
        755                 760                 765             


Ile Ile Pro Asn Leu Leu Pro Gln Gly Ala Gly Glu Glu Ile Gly Lys 
    770                 775                 780                 


Thr Ala Ala Phe Arg Asn Ser Phe Gly Leu Asn 
785                 790                 795 

<210>  2266
<211>  1550
<212>  DNA
<213>  Homo sapiens

<400>  2266
cggataactc agacgccatt aagctgggga atccaaactc taaaagaagg acgcatttta     60

gtgacacaga gaacactgga cagagagagc caagccgagt acaacatcac catcactgtc    120

accgacatgg ggacacccag gctgaaaacc gagcacaaca taacggtcct ggtctccgac    180

gtcaatgaca acgcccccgc cttcacccaa acctcctaca ccctgttcgt ccgagagaac    240

aacagccccg ccctgcacat cggcagtgtc agcgccacag acagagactc aggcaccaac    300

gcccaggtca cctactcgct gctgccgccc cagaacccac acctgcgcct cgcctccctg    360

gtctccatca acgcggacaa cggccacctg tttgccctca ggtcgctgga ctacgaggcc    420

ctgcaggcgt tcgagttccg cgtgggagcc acagaccgcg gctccccggc gctgagcagc    480

gaggcgctgg tgcgcgtgct ggtgctggac gccaacgaca actcgccctt cgtgctgtat    540

ccgctgcaga acggctcggc gccttgcacc gagctggtgc cccgggcggc cgagccgggc    600

tacctggtga ccaaggtggt ggcggtggac ggcgactcgg gccagaacgc ctggctgtcg    660

taccagctgc tcaaggccac ggagcccggg ctgttcagca tgtgggcgca caatggcgag    720

gtgcgcaccg ccaggctgct gagcgagcgc gacgcggcca agcacaggct ggtggtgctg    780

gtcaaggaca atggcgagcc tccgcgctcg gccaccgcca cgctgcacgt gctcctggtg    840

gacggcttct cccagcccta cctgccgctg ccggaggcgg ccccggccca ggcccaggcc    900

gactcgctca ctgtctacct ggtggtggca ttggcctcgg tgtcgtcgct cttcctcttt    960

tcggtgctcc tgttcgtggc agtgcggctg tgcaggagga gcagggcggc ctcggtcggt   1020

cgctgctcgg tgcccgaggg cccctttcca gggcatctgg tggacgtgag cggcaccggg   1080

accctatccc agagctacca ctacgaggtg tgtttgaccg gagactcagg ggccggcgag   1140

ttcaagttcc tgaagccgat tattcctaac cttttgcccc agggcgctgg tgaagaaata   1200

gggaaaactg ctgccttccg gaatagcttt ggattaaatt agagatctcg tgatgacgcg   1260

ttgttttctg ccatttatcc caaacttttt cagatctaga attcgagagt gtcatggaca   1320

aaaatttcac cttgagattg agcttttatt tcccttttta atggatttgt ctgttgaact   1380

tcatgctgtc caagtgttga aaagtcaatt ttatttcatt gcatttattt acatagtgtc   1440

attccaaatc catgcatgct gttgattttc ctgagatttt tttctcttct tgttggtatt   1500

tgttgtgata aaccacctta ataaaatcaa gtattaattt tattttctat              1550


<210>  2267
<211>  371
<212>  PRT
<213>  Homo sapiens

<400>  2267


Met Gly Thr Pro Arg Leu Lys Thr Glu His Asn Ile Thr Val Leu Val 
1               5                   10                  15      


Ser Asp Val Asn Asp Asn Ala Pro Ala Phe Thr Gln Thr Ser Tyr Thr 
            20                  25                  30          


Leu Phe Val Arg Glu Asn Asn Ser Pro Ala Leu His Ile Gly Ser Val 
        35                  40                  45              


Ser Ala Thr Asp Arg Asp Ser Gly Thr Asn Ala Gln Val Thr Tyr Ser 
    50                  55                  60                  


Leu Leu Pro Pro Gln Asn Pro His Leu Arg Leu Ala Ser Leu Val Ser 
65                  70                  75                  80  


Ile Asn Ala Asp Asn Gly His Leu Phe Ala Leu Arg Ser Leu Asp Tyr 
                85                  90                  95      


Glu Ala Leu Gln Ala Phe Glu Phe Arg Val Gly Ala Thr Asp Arg Gly 
            100                 105                 110         


Ser Pro Ala Leu Ser Ser Glu Ala Leu Val Arg Val Leu Val Leu Asp 
        115                 120                 125             


Ala Asn Asp Asn Ser Pro Phe Val Leu Tyr Pro Leu Gln Asn Gly Ser 
    130                 135                 140                 


Ala Pro Cys Thr Glu Leu Val Pro Arg Ala Ala Glu Pro Gly Tyr Leu 
145                 150                 155                 160 


Val Thr Lys Val Val Ala Val Asp Gly Asp Ser Gly Gln Asn Ala Trp 
                165                 170                 175     


Leu Ser Tyr Gln Leu Leu Lys Ala Thr Glu Pro Gly Leu Phe Ser Met 
            180                 185                 190         


Trp Ala His Asn Gly Glu Val Arg Thr Ala Arg Leu Leu Ser Glu Arg 
        195                 200                 205             


Asp Ala Ala Lys His Arg Leu Val Val Leu Val Lys Asp Asn Gly Glu 
    210                 215                 220                 


Pro Pro Arg Ser Ala Thr Ala Thr Leu His Val Leu Leu Val Asp Gly 
225                 230                 235                 240 


Phe Ser Gln Pro Tyr Leu Pro Leu Pro Glu Ala Ala Pro Ala Gln Ala 
                245                 250                 255     


Gln Ala Asp Ser Leu Thr Val Tyr Leu Val Val Ala Leu Ala Ser Val 
            260                 265                 270         


Ser Ser Leu Phe Leu Phe Ser Val Leu Leu Phe Val Ala Val Arg Leu 
        275                 280                 285             


Cys Arg Arg Ser Arg Ala Ala Ser Val Gly Arg Cys Ser Val Pro Glu 
    290                 295                 300                 


Gly Pro Phe Pro Gly His Leu Val Asp Val Ser Gly Thr Gly Thr Leu 
305                 310                 315                 320 


Ser Gln Ser Tyr His Tyr Glu Val Cys Leu Thr Gly Asp Ser Gly Ala 
                325                 330                 335     


Gly Glu Phe Lys Phe Leu Lys Pro Ile Ile Pro Asn Leu Leu Pro Gln 
            340                 345                 350         


Gly Ala Gly Glu Glu Ile Gly Lys Thr Ala Ala Phe Arg Asn Ser Phe 
        355                 360                 365             


Gly Leu Asn 
    370     

<210>  2268
<211>  588
<212>  DNA
<213>  Homo sapiens

<400>  2268
ggataactca gacgccatta agctggggaa tccaaactct aaaagaagga cgcattttag     60

gtaagatcta gtggctagat cttcagggtg ggcttcgttc ttgtggaaat cagtcaagaa    120

agatcggatt cgcggttatt tatgcaaatc atctgggtgg attgtgtacg gagttaaact    180

gcgccttctg gaccgggtct gaacaatgga gactgcgcta gcaaaaacgc cacagaaaag    240

gcaagttatg tttcttgcta tattgttgct tttgtgggag gctggctctg aggcagttag    300

gtattccata ccagaagaaa cagaaagtgg ctattctgtg gccaacctgg caaaagacct    360

gggtcttggg gtgggggaac tggccactcg gggcgcgcga atgcattaca aaggaaacaa    420

agagctcttg cagagatata aatgaccatg ccccagagtt cccagagaag gaaatgctcc    480

taaaaatccc agagagcacc cagccaggga ctgtgtttcc cttaaaaata gcccaggact    540

ttgacatagg tagcaacact gttcagaact acacaatcag cccaaatt                 588


<210>  2269
<211>  79
<212>  PRT
<213>  Homo sapiens

<400>  2269


Met Glu Thr Ala Leu Ala Lys Thr Pro Gln Lys Arg Gln Val Met Phe 
1               5                   10                  15      


Leu Ala Ile Leu Leu Leu Leu Trp Glu Ala Gly Ser Glu Ala Val Arg 
            20                  25                  30          


Tyr Ser Ile Pro Glu Glu Thr Glu Ser Gly Tyr Ser Val Ala Asn Leu 
        35                  40                  45              


Ala Lys Asp Leu Gly Leu Gly Val Gly Glu Leu Ala Thr Arg Gly Ala 
    50                  55                  60                  


Arg Met His Tyr Lys Gly Asn Lys Glu Leu Leu Gln Arg Tyr Lys 
65                  70                  75                  

<210>  2270
<211>  6585
<212>  DNA
<213>  Homo sapiens

<400>  2270
gataagcact taatgagtgc cttctctgtg cgagaatggg gaggaacaaa atgcagctcc     60

taccctcctc gggctttagt tgtaccttaa taacaggaat tttcatctgc ctggctcctt    120

tcctcaaaga acaaagaaga ctttgcttca ttaaagtgtc tgagaaggaa ggtttgaaca    180

ggatccctct ggctggtgtg tgaagaatta actgtagatg ggcaagtgtg gaaggaagga    240

gagcagtcag gaagctgcca taaccatcta catgagagag ttgatattca ctgatggact    300

ccaaagaatc attaactcct ggtagagaag aaaaccccag cagtgtgctt gctcaggaga    360

ggggagatgt gatggacttc tataaaaccc taagaggagg agctactgtg aaggtttctg    420

cgtcttcacc ctcactggct gtcgcttctc aatcagactc caagcagcga agacttttgg    480

ttgattttcc aaaaggctca gtaagcaatg cgcagcagcc agatctgtcc aaagcagttt    540

cactctcaat gggactgtat atgggagaga cagaaacaaa agtgatggga aatgacctgg    600

gattcccaca gcagggccaa atcagccttt cctcggggga aacagactta aagcttttgg    660

aagaaagcat tgcaaacctc aataggtcga ccagtgttcc agagaacccc aagagttcag    720

catccactgc tgtgtctgct gcccccacag agaaggagtt tccaaaaact cactctgatg    780

tatcttcaga acagcaacat ttgaagggcc agactggcac caacggtggc aatgtgaaat    840

tgtataccac agaccaaagc acctttgaca ttttgcagga tttggagttt tcttctgggt    900

ccccaggtaa agagacgaat gagagtcctt ggagatcaga cctgttgata gatgaaaact    960

gtttgctttc tcctctggcg ggagaagacg attcattcct tttggaagga aactcgaatg   1020

aggactgcaa gcctctcatt ttaccggaca ctaaacccaa aattaaggat aatggagatc   1080

tggttttgtc aagccccagt aatgtaacac tgccccaagt gaaaacagaa aaagaagatt   1140

tcatcgaact ctgcacccct ggggtaatta agcaagagaa actgggcaca gtttactgtc   1200

aggcaagctt tcctggagca aatataattg gtaataaaat gtctgccatt tctgttcatg   1260

gtgtgagtac ctctggagga cagatgtacc actatgacat gaatacagca tccctttctc   1320

aacagcagga tcagaagcct atttttaatg tcattccacc aattcccgtt ggttccgaaa   1380

attggaatag gtgccaagga tctggagatg acaacttgac ttctctgggg actctgaact   1440

tccctggtcg aacagttttt tctaatggct attcaagccc cagcatgaga ccagatgtaa   1500

gctctcctcc atccagctcc tcaacagcaa caacaggacc acctcccaaa ctctgcctgg   1560

tgtgctctga tgaagcttca ggatgtcatt atggagtctt aacttgtgga agctgtaaag   1620

ttttcttcaa aagagcagtg gaaggacagc acaattacct atgtgctgga aggaatgatt   1680

gcatcatcga taaaattcga agaaaaaact gcccagcatg ccgctatcga aaatgtcttc   1740

aggctggaat gaacctggaa gctcgaaaaa caaagaaaaa aataaaagga attcagcagg   1800

ccactacagg agtctcacaa gaaacctctg aaaatcctgg taacaaaaca atagttcctg   1860

caacgttacc acaactcacc cctaccctgg tgtcactgtt ggaggttatt gaacctgaag   1920

tgttatatgc aggatatgat agctctgttc cagactcaac ttggaggatc atgactacgc   1980

tcaacatgtt aggagggcgg caagtgattg cagcagtgaa atgggcaaag gcaataccag   2040

gtttcaggaa cttacacctg gatgaccaaa tgaccctact gcagtactcc tggatgtttc   2100

ttatggcatt tgctctgggg tggagatcat atagacaatc aagtgcaaac ctgctgtgtt   2160

ttgctcctga tctgattatt aatgagcaga gaatgactct accctgcatg tacgaccaat   2220

gtaaacacat gctgtatgtt tcctctgagt tacacaggct tcaggtatct tatgaagagt   2280

atctctgtat gaaaacctta ctgcttctct cttcagttcc taaggacggt ctgaagagcc   2340

aagagctatt tgatgaaatt agaatgacct acatcaaaga gctaggaaaa gccattgtca   2400

agagggaagg aaactccagc cagaactggc agcggtttta tcaactgaca aaactcttgg   2460

attctatgca tgaagtggtt gaaaatctcc ttaactattg cttccaaaca tttttggata   2520

agaccatgag tattgaattc cccgagatgt tagctgaaat catcaccaat cagataccaa   2580

aatattcaaa tggaaatatc aaaaaacttc tgtttcatca aaagtgactg ccttaataag   2640

aatggttgcc ttaaagaaag tcgaattaat agcttttatt gtataaacta tcagtttgtc   2700

ctgtagaggt tttgttgttt tattttttat tgttttcatc tgttgttttg ttttaaatac   2760

gcactacatg tggtttatag agggccaaga cttggcaaca gaagcagttg agtcgtcatc   2820

acttttcagt gatgggagag tagatggtga aatttattag ttaatatatc ccagaaatta   2880

gaaaccttaa tatgtggacg taatctccac agtcaaagaa ggatggcacc taaaccacca   2940

gtgcccaaag tctgtgtgat gaactttctc ttcatacttt ttttcacagt tggctggatg   3000

aaattttcta gactttctgt tggtgtatcc cccccctgta tagttaggat agcatttttg   3060

atttatgcat ggaaacctga aaaaaagttt acaagtgtat atcagaaaag ggaagttgtg   3120

ccttttatag ctattactgt ctggttttaa caatttcctt tatatttagt gaactacgct   3180

tgctcatttt ttcttacata attttttatt caagttattg tacagctgtt taagatgggc   3240

agctagttcg tagctttccc aaataaactc taaacattaa tcaatcatct gtgtgaaaat   3300

gggttggtgc ttctaacctg atggcactta gctatcagaa gaccacaaaa attgactcaa   3360

atctccagta ttcttgtcaa aaaaaaaaaa aaaaaagctc atattttgta tatatctgct   3420

tcagtggaga attatatagg ttgtgcaaat taacagtcct aactggtata gagcacctag   3480

tccagtgacc tgctgggtaa actgtggatg atggttgcaa aagactaatt taaaaaataa   3540

ctaccaagag gccctgtctg tacctaacgc cctatttttg caatggctat atggcaagaa   3600

agctggtaaa ctatttgtct ttcaggacct tttgaagtag tttgtataac ttcttaaaag   3660

ttgtgattcc agataaccag ctgtaacaca gctgagagac ttttaatcag acaaagtaat   3720

tcctctcact aaactttacc caaaaactaa atctctaata tggcaaaaat ggctagacac   3780

ccattttcac attcccatct gtcaccaatt ggttaatctt tcctgatggt acaggaaagc   3840

tcagctactg atttttgtga tttagaactg tatgtcagac atccatgttt gtaaaactac   3900

acatccctaa tgtgtgccat agagtttaac acaagtcctg tgaatttctt cactgttgaa   3960

aattatttta aacaaaatag aagctgtagt agccctttct gtgtgcacct taccaacttt   4020

ctgtaaactc aaaacttaac atatttacta agccacaaga aatttgattt ctattcaagg   4080

tggccaaatt atttgtgtaa tagaaaactg aaaatctaat attaaaaata tggaacttct   4140

aatatatttt tatatttagt tatagtttca gatatatatc atattggtat tcactaatct   4200

gggaagggaa gggctactgc agctttacat gcaatttatt aaaatgattg taaaatagct   4260

tgtatagtgt aaaataagaa tgatttttag atgagattgt tttatcatga catgttatat   4320

attttttgta ggggtcaaag aaatgctgat ggataaccta tatgatttat agtttgtaca   4380

tgcattcata caggcagcga tggtctcaga aaccaaacag tttgctctag gggaagaggg   4440

agatggagac tggtcctgtg tgcagtgaag gttgctgagg ctctgaccca gtgagattac   4500

agaggaagtt atcctctgcc tcccattctg accacccttc tcattccaac agtgagtctg   4560

tcagcgcagg tttagtttac tcaatctccc cttgcactaa agtatgtaaa gtatgtaaac   4620

aggagacagg aaggtggtgc ttacatcctt aaaggcacca tctaatagcg ggttactttc   4680

acatacagcc ctcccccagc agttgaatga caacagaagc ttcagaagtt tggcaatagt   4740

ttgcatagag gtaccagcaa tatgtaaata gtgcagaatc tcataggttg ccaataatac   4800

actaattcct ttctatccta caacaagagt ttatttccaa ataaaatgag gacatgtttt   4860

tgttttcttt gaatgctttt tgaatgttat ttgttatttt cagtattttg gagaaattat   4920

ttaataaaaa aacaatcatt tgctttttga atgctctcta aaagggaatg taatatttta   4980

agatggtgtg taacccggct ggataaattt ttggtgccta agaaaactgc ttgaatattc   5040

ttatcaatga cagtgttaag tttcaaaaag agcttctaaa acgtagatta tcattccttt   5100

atagaatgtt atgtggttaa aaccagaaag cacatctcac acattaatct gattttcatc   5160

ccaacaatct tggcgctcaa aaaatagaac tcaatgagaa aaagaagatt atgtgcactt   5220

cgttgtcaat aataagtcaa ctgatgctca tcgacaacta taggaggctt ttcattaaat   5280

gggaaaagaa gctgtgccct tttaggatac gtgggggaaa agaaagtcat cttaattatg   5340

tttaattgtg gatttaagtg ctatatggtg gtgctgtttg aaagcagatt tatttcctat   5400

gtatgtgtta tctggccatc ccaacccaaa ctgttgaagt ttgtagtaac ttcagtgaga   5460

gttggttact cacaacaaat cctgaaaagt atttttagtg tttgtaggta ttctgtggga   5520

tactatacaa gcagaactga ggcacttagg acataacact tttggggtat atatatccaa   5580

atgcctaaaa ctatgggagg aaaccttggc caccccaaaa ggaaaactaa catgatttgt   5640

gtctatgaag tgctggataa ttagcatggg atgagctctg ggcatgccat gaaggaaagc   5700

cacgctccct tcagaattca gaggcaggga gcaattccag tttcacctaa gtctcataat   5760

tttagttccc ttttaaaaac cctgaaaact acatcaccat ggaatgaaaa atattgttat   5820

acaatacatt gatctgtcaa acttccagaa ccatggtagc cttcagtgag atttccatct   5880

tggctggtca ctccctgact gtagctgtag gtgaatgtgt ttttgtgtgt gtgtgtctgg   5940

ttttagtgtc agaagggaaa taaaagtgta aggaggacac tttaaaccct ttgggtggag   6000

tttcgtaatt tcccagacta ttttcaagca acctggtcca cccaggatta gtgaccaggt   6060

tttcaggaaa ggatttgctt ctctctagaa aatgtctgaa aggattttat tttctgatga   6120

aaggctgtat gaaaataccc tcctcaaata acttgcttaa ctacatatag attcaagtgt   6180

gtcaatattc tattttgtat attaaatgct atataatggg gacaaatcta tattatactg   6240

tgtatggcat tattaagaag ctttttcatt attttttatc acagtaattt taaaatgtgt   6300

aaaaattaaa accagtgact cctgtttaaa aataaaagtt gtagtttttt attcatgctg   6360

aataataatc tgtagttaaa aaaaaagtgt ctttttacct acgcagtgaa atgtcagact   6420

gtaaaacctt gtgtggaaat gtttaacttt tattttttca tttaaatttg ctgttctggt   6480

attaccaaac cacacatttg taccgaattg gcagtaaatg ttagccattt acagcaatgc   6540

caaatatgga gaaacatcat aataaaaaaa tctgcttttt catta                   6585


<210>  2271
<211>  777
<212>  PRT
<213>  Homo sapiens

<400>  2271


Met Asp Ser Lys Glu Ser Leu Thr Pro Gly Arg Glu Glu Asn Pro Ser 
1               5                   10                  15      


Ser Val Leu Ala Gln Glu Arg Gly Asp Val Met Asp Phe Tyr Lys Thr 
            20                  25                  30          


Leu Arg Gly Gly Ala Thr Val Lys Val Ser Ala Ser Ser Pro Ser Leu 
        35                  40                  45              


Ala Val Ala Ser Gln Ser Asp Ser Lys Gln Arg Arg Leu Leu Val Asp 
    50                  55                  60                  


Phe Pro Lys Gly Ser Val Ser Asn Ala Gln Gln Pro Asp Leu Ser Lys 
65                  70                  75                  80  


Ala Val Ser Leu Ser Met Gly Leu Tyr Met Gly Glu Thr Glu Thr Lys 
                85                  90                  95      


Val Met Gly Asn Asp Leu Gly Phe Pro Gln Gln Gly Gln Ile Ser Leu 
            100                 105                 110         


Ser Ser Gly Glu Thr Asp Leu Lys Leu Leu Glu Glu Ser Ile Ala Asn 
        115                 120                 125             


Leu Asn Arg Ser Thr Ser Val Pro Glu Asn Pro Lys Ser Ser Ala Ser 
    130                 135                 140                 


Thr Ala Val Ser Ala Ala Pro Thr Glu Lys Glu Phe Pro Lys Thr His 
145                 150                 155                 160 


Ser Asp Val Ser Ser Glu Gln Gln His Leu Lys Gly Gln Thr Gly Thr 
                165                 170                 175     


Asn Gly Gly Asn Val Lys Leu Tyr Thr Thr Asp Gln Ser Thr Phe Asp 
            180                 185                 190         


Ile Leu Gln Asp Leu Glu Phe Ser Ser Gly Ser Pro Gly Lys Glu Thr 
        195                 200                 205             


Asn Glu Ser Pro Trp Arg Ser Asp Leu Leu Ile Asp Glu Asn Cys Leu 
    210                 215                 220                 


Leu Ser Pro Leu Ala Gly Glu Asp Asp Ser Phe Leu Leu Glu Gly Asn 
225                 230                 235                 240 


Ser Asn Glu Asp Cys Lys Pro Leu Ile Leu Pro Asp Thr Lys Pro Lys 
                245                 250                 255     


Ile Lys Asp Asn Gly Asp Leu Val Leu Ser Ser Pro Ser Asn Val Thr 
            260                 265                 270         


Leu Pro Gln Val Lys Thr Glu Lys Glu Asp Phe Ile Glu Leu Cys Thr 
        275                 280                 285             


Pro Gly Val Ile Lys Gln Glu Lys Leu Gly Thr Val Tyr Cys Gln Ala 
    290                 295                 300                 


Ser Phe Pro Gly Ala Asn Ile Ile Gly Asn Lys Met Ser Ala Ile Ser 
305                 310                 315                 320 


Val His Gly Val Ser Thr Ser Gly Gly Gln Met Tyr His Tyr Asp Met 
                325                 330                 335     


Asn Thr Ala Ser Leu Ser Gln Gln Gln Asp Gln Lys Pro Ile Phe Asn 
            340                 345                 350         


Val Ile Pro Pro Ile Pro Val Gly Ser Glu Asn Trp Asn Arg Cys Gln 
        355                 360                 365             


Gly Ser Gly Asp Asp Asn Leu Thr Ser Leu Gly Thr Leu Asn Phe Pro 
    370                 375                 380                 


Gly Arg Thr Val Phe Ser Asn Gly Tyr Ser Ser Pro Ser Met Arg Pro 
385                 390                 395                 400 


Asp Val Ser Ser Pro Pro Ser Ser Ser Ser Thr Ala Thr Thr Gly Pro 
                405                 410                 415     


Pro Pro Lys Leu Cys Leu Val Cys Ser Asp Glu Ala Ser Gly Cys His 
            420                 425                 430         


Tyr Gly Val Leu Thr Cys Gly Ser Cys Lys Val Phe Phe Lys Arg Ala 
        435                 440                 445             


Val Glu Gly Gln His Asn Tyr Leu Cys Ala Gly Arg Asn Asp Cys Ile 
    450                 455                 460                 


Ile Asp Lys Ile Arg Arg Lys Asn Cys Pro Ala Cys Arg Tyr Arg Lys 
465                 470                 475                 480 


Cys Leu Gln Ala Gly Met Asn Leu Glu Ala Arg Lys Thr Lys Lys Lys 
                485                 490                 495     


Ile Lys Gly Ile Gln Gln Ala Thr Thr Gly Val Ser Gln Glu Thr Ser 
            500                 505                 510         


Glu Asn Pro Gly Asn Lys Thr Ile Val Pro Ala Thr Leu Pro Gln Leu 
        515                 520                 525             


Thr Pro Thr Leu Val Ser Leu Leu Glu Val Ile Glu Pro Glu Val Leu 
    530                 535                 540                 


Tyr Ala Gly Tyr Asp Ser Ser Val Pro Asp Ser Thr Trp Arg Ile Met 
545                 550                 555                 560 


Thr Thr Leu Asn Met Leu Gly Gly Arg Gln Val Ile Ala Ala Val Lys 
                565                 570                 575     


Trp Ala Lys Ala Ile Pro Gly Phe Arg Asn Leu His Leu Asp Asp Gln 
            580                 585                 590         


Met Thr Leu Leu Gln Tyr Ser Trp Met Phe Leu Met Ala Phe Ala Leu 
        595                 600                 605             


Gly Trp Arg Ser Tyr Arg Gln Ser Ser Ala Asn Leu Leu Cys Phe Ala 
    610                 615                 620                 


Pro Asp Leu Ile Ile Asn Glu Gln Arg Met Thr Leu Pro Cys Met Tyr 
625                 630                 635                 640 


Asp Gln Cys Lys His Met Leu Tyr Val Ser Ser Glu Leu His Arg Leu 
                645                 650                 655     


Gln Val Ser Tyr Glu Glu Tyr Leu Cys Met Lys Thr Leu Leu Leu Leu 
            660                 665                 670         


Ser Ser Val Pro Lys Asp Gly Leu Lys Ser Gln Glu Leu Phe Asp Glu 
        675                 680                 685             


Ile Arg Met Thr Tyr Ile Lys Glu Leu Gly Lys Ala Ile Val Lys Arg 
    690                 695                 700                 


Glu Gly Asn Ser Ser Gln Asn Trp Gln Arg Phe Tyr Gln Leu Thr Lys 
705                 710                 715                 720 


Leu Leu Asp Ser Met His Glu Val Val Glu Asn Leu Leu Asn Tyr Cys 
                725                 730                 735     


Phe Gln Thr Phe Leu Asp Lys Thr Met Ser Ile Glu Phe Pro Glu Met 
            740                 745                 750         


Leu Ala Glu Ile Ile Thr Asn Gln Ile Pro Lys Tyr Ser Asn Gly Asn 
        755                 760                 765             


Ile Lys Lys Leu Leu Phe His Gln Lys 
    770                 775         

<210>  2272
<211>  7286
<212>  DNA
<213>  Homo sapiens

<400>  2272
aggttatgta agggtttgct ttcaccccat tcaaaaggta cctcttcctc ttctcttgct     60

ccctctcgcc ctcattcttg tgcctatgca gacatttgag tagaggcgaa tcactttcac    120

ttctgctggg gaaattgcaa cacgcttctt taaatggcag agagaaggag aaaacttaga    180

tcttctgata ccaaatcact ggaccttaga aggtcagaaa tctttcaagc cctgcaggac    240

cgtaaaatgc gcatgtgtcc aacggaagca ctggggcatg agtggggaag gaatagaaac    300

agaaagaggg taagagaaga aaaaagggaa agtggtgaag gcagggagga aaattgctta    360

gtgtgaatat gcacgcattc atttagtttt caaatccttg ttgagcatga taaaattccc    420

agcatcagac ctcacatgtt ggtttccatt aggatctgcc tgggggaata tctgctgaat    480

cagtggctct gagctgaact aggaaattca ccataattag gagagtcact gtatttctct    540

ccaaaaaaaa aaaagttata cccgagagac aggatcttct gatctgaaat tttcttcact    600

tctgaaattc tctggtttgt gctcatcgtt ggtagctatt tgttcatcaa gagttgtgta    660

gctggcttct tctgaaaaaa ggaatctgcg tcatatctaa gtcagatttc attctggtgc    720

tctcagagca gttagcccag gaaaggggcc agcttctgtg acgactgctg cagaggcagg    780

tgcagtttgt gtgccacaga tattaacttt gataagcact taatgagtgc cttctctgtg    840

cgagaatggg gaggaacaaa atgcagctcc taccctcctc gggctttagt tgtaccttaa    900

taacaggaat tttcatctgc ctggctcctt tcctcaaaga acaaagaaga ctttgcttca    960

ttaaagtgtc tgagaaggaa gttgatattc actgatggac tccaaagaat cattaactcc   1020

tggtagagaa gaaaacccca gcagtgtgct tgctcaggag aggggagatg tgatggactt   1080

ctataaaacc ctaagaggag gagctactgt gaaggtttct gcgtcttcac cctcactggc   1140

tgtcgcttct caatcagact ccaagcagcg aagacttttg gttgattttc caaaaggctc   1200

agtaagcaat gcgcagcagc cagatctgtc caaagcagtt tcactctcaa tgggactgta   1260

tatgggagag acagaaacaa aagtgatggg aaatgacctg ggattcccac agcagggcca   1320

aatcagcctt tcctcggggg aaacagactt aaagcttttg gaagaaagca ttgcaaacct   1380

caataggtcg accagtgttc cagagaaccc caagagttca gcatccactg ctgtgtctgc   1440

tgcccccaca gagaaggagt ttccaaaaac tcactctgat gtatcttcag aacagcaaca   1500

tttgaagggc cagactggca ccaacggtgg caatgtgaaa ttgtatacca cagaccaaag   1560

cacctttgac attttgcagg atttggagtt ttcttctggg tccccaggta aagagacgaa   1620

tgagagtcct tggagatcag acctgttgat agatgaaaac tgtttgcttt ctcctctggc   1680

gggagaagac gattcattcc ttttggaagg aaactcgaat gaggactgca agcctctcat   1740

tttaccggac actaaaccca aaattaagga taatggagat ctggttttgt caagccccag   1800

taatgtaaca ctgccccaag tgaaaacaga aaaagaagat ttcatcgaac tctgcacccc   1860

tggggtaatt aagcaagaga aactgggcac agtttactgt caggcaagct ttcctggagc   1920

aaatataatt ggtaataaaa tgtctgccat ttctgttcat ggtgtgagta cctctggagg   1980

acagatgtac cactatgaca tgaatacagc atccctttct caacagcagg atcagaagcc   2040

tatttttaat gtcattccac caattcccgt tggttccgaa aattggaata ggtgccaagg   2100

atctggagat gacaacttga cttctctggg gactctgaac ttccctggtc gaacagtttt   2160

ttctaatggc tattcaagcc ccagcatgag accagatgta agctctcctc catccagctc   2220

ctcaacagca acaacaggac cacctcccaa actctgcctg gtgtgctctg atgaagcttc   2280

aggatgtcat tatggagtct taacttgtgg aagctgtaaa gttttcttca aaagagcagt   2340

ggaaggacag cacaattacc tatgtgctgg aaggaatgat tgcatcatcg ataaaattcg   2400

aagaaaaaac tgcccagcat gccgctatcg aaaatgtctt caggctggaa tgaacctgga   2460

agctcgaaaa acaaagaaaa aaataaaagg aattcagcag gccactacag gagtctcaca   2520

agaaacctct gaaaatcctg gtaacaaaac aatagttcct gcaacgttac cacaactcac   2580

ccctaccctg gtgtcactgt tggaggttat tgaacctgaa gtgttatatg caggatatga   2640

tagctctgtt ccagactcaa cttggaggat catgactacg ctcaacatgt taggagggcg   2700

gcaagtgatt gcagcagtga aatgggcaaa ggcaatacca ggtttcagga acttacacct   2760

ggatgaccaa atgaccctac tgcagtactc ctggatgttt cttatggcat ttgctctggg   2820

gtggagatca tatagacaat caagtgcaaa cctgctgtgt tttgctcctg atctgattat   2880

taatgagcag agaatgactc taccctgcat gtacgaccaa tgtaaacaca tgctgtatgt   2940

ttcctctgag ttacacaggc ttcaggtatc ttatgaagag tatctctgta tgaaaacctt   3000

actgcttctc tcttcagttc ctaaggacgg tctgaagagc caagagctat ttgatgaaat   3060

tagaatgacc tacatcaaag agctaggaaa agccattgtc aagagggaag gaaactccag   3120

ccagaactgg cagcggtttt atcaactgac aaaactcttg gattctatgc atgaagtggt   3180

tgaaaatctc cttaactatt gcttccaaac atttttggat aagaccatga gtattgaatt   3240

ccccgagatg ttagctgaaa tcatcaccaa tcagatacca aaatattcaa atggaaatat   3300

caaaaaactt ctgtttcatc aaaagtgact gccttaataa gaatggttgc cttaaagaaa   3360

gtcgaattaa tagcttttat tgtataaact atcagtttgt cctgtagagg ttttgttgtt   3420

ttatttttta ttgttttcat ctgttgtttt gttttaaata cgcactacat gtggtttata   3480

gagggccaag acttggcaac agaagcagtt gagtcgtcat cacttttcag tgatgggaga   3540

gtagatggtg aaatttatta gttaatatat cccagaaatt agaaacctta atatgtggac   3600

gtaatctcca cagtcaaaga aggatggcac ctaaaccacc agtgcccaaa gtctgtgtga   3660

tgaactttct cttcatactt tttttcacag ttggctggat gaaattttct agactttctg   3720

ttggtgtatc ccccccctgt atagttagga tagcattttt gatttatgca tggaaacctg   3780

aaaaaaagtt tacaagtgta tatcagaaaa gggaagttgt gccttttata gctattactg   3840

tctggtttta acaatttcct ttatatttag tgaactacgc ttgctcattt tttcttacat   3900

aattttttat tcaagttatt gtacagctgt ttaagatggg cagctagttc gtagctttcc   3960

caaataaact ctaaacatta atcaatcatc tgtgtgaaaa tgggttggtg cttctaacct   4020

gatggcactt agctatcaga agaccacaaa aattgactca aatctccagt attcttgtca   4080

aaaaaaaaaa aaaaaaagct catattttgt atatatctgc ttcagtggag aattatatag   4140

gttgtgcaaa ttaacagtcc taactggtat agagcaccta gtccagtgac ctgctgggta   4200

aactgtggat gatggttgca aaagactaat ttaaaaaata actaccaaga ggccctgtct   4260

gtacctaacg ccctattttt gcaatggcta tatggcaaga aagctggtaa actatttgtc   4320

tttcaggacc ttttgaagta gtttgtataa cttcttaaaa gttgtgattc cagataacca   4380

gctgtaacac agctgagaga cttttaatca gacaaagtaa ttcctctcac taaactttac   4440

ccaaaaacta aatctctaat atggcaaaaa tggctagaca cccattttca cattcccatc   4500

tgtcaccaat tggttaatct ttcctgatgg tacaggaaag ctcagctact gatttttgtg   4560

atttagaact gtatgtcaga catccatgtt tgtaaaacta cacatcccta atgtgtgcca   4620

tagagtttaa cacaagtcct gtgaatttct tcactgttga aaattatttt aaacaaaata   4680

gaagctgtag tagccctttc tgtgtgcacc ttaccaactt tctgtaaact caaaacttaa   4740

catatttact aagccacaag aaatttgatt tctattcaag gtggccaaat tatttgtgta   4800

atagaaaact gaaaatctaa tattaaaaat atggaacttc taatatattt ttatatttag   4860

ttatagtttc agatatatat catattggta ttcactaatc tgggaaggga agggctactg   4920

cagctttaca tgcaatttat taaaatgatt gtaaaatagc ttgtatagtg taaaataaga   4980

atgattttta gatgagattg ttttatcatg acatgttata tattttttgt aggggtcaaa   5040

gaaatgctga tggataacct atatgattta tagtttgtac atgcattcat acaggcagcg   5100

atggtctcag aaaccaaaca gtttgctcta ggggaagagg gagatggaga ctggtcctgt   5160

gtgcagtgaa ggttgctgag gctctgaccc agtgagatta cagaggaagt tatcctctgc   5220

ctcccattct gaccaccctt ctcattccaa cagtgagtct gtcagcgcag gtttagttta   5280

ctcaatctcc ccttgcacta aagtatgtaa agtatgtaaa caggagacag gaaggtggtg   5340

cttacatcct taaaggcacc atctaatagc gggttacttt cacatacagc cctcccccag   5400

cagttgaatg acaacagaag cttcagaagt ttggcaatag tttgcataga ggtaccagca   5460

atatgtaaat agtgcagaat ctcataggtt gccaataata cactaattcc tttctatcct   5520

acaacaagag tttatttcca aataaaatga ggacatgttt ttgttttctt tgaatgcttt   5580

ttgaatgtta tttgttattt tcagtatttt ggagaaatta tttaataaaa aaacaatcat   5640

ttgctttttg aatgctctct aaaagggaat gtaatatttt aagatggtgt gtaacccggc   5700

tggataaatt tttggtgcct aagaaaactg cttgaatatt cttatcaatg acagtgttaa   5760

gtttcaaaaa gagcttctaa aacgtagatt atcattcctt tatagaatgt tatgtggtta   5820

aaaccagaaa gcacatctca cacattaatc tgattttcat cccaacaatc ttggcgctca   5880

aaaaatagaa ctcaatgaga aaaagaagat tatgtgcact tcgttgtcaa taataagtca   5940

actgatgctc atcgacaact ataggaggct tttcattaaa tgggaaaaga agctgtgccc   6000

ttttaggata cgtgggggaa aagaaagtca tcttaattat gtttaattgt ggatttaagt   6060

gctatatggt ggtgctgttt gaaagcagat ttatttccta tgtatgtgtt atctggccat   6120

cccaacccaa actgttgaag tttgtagtaa cttcagtgag agttggttac tcacaacaaa   6180

tcctgaaaag tatttttagt gtttgtaggt attctgtggg atactataca agcagaactg   6240

aggcacttag gacataacac ttttggggta tatatatcca aatgcctaaa actatgggag   6300

gaaaccttgg ccaccccaaa aggaaaacta acatgatttg tgtctatgaa gtgctggata   6360

attagcatgg gatgagctct gggcatgcca tgaaggaaag ccacgctccc ttcagaattc   6420

agaggcaggg agcaattcca gtttcaccta agtctcataa ttttagttcc cttttaaaaa   6480

ccctgaaaac tacatcacca tggaatgaaa aatattgtta tacaatacat tgatctgtca   6540

aacttccaga accatggtag ccttcagtga gatttccatc ttggctggtc actccctgac   6600

tgtagctgta ggtgaatgtg tttttgtgtg tgtgtgtctg gttttagtgt cagaagggaa   6660

ataaaagtgt aaggaggaca ctttaaaccc tttgggtgga gtttcgtaat ttcccagact   6720

attttcaagc aacctggtcc acccaggatt agtgaccagg ttttcaggaa aggatttgct   6780

tctctctaga aaatgtctga aaggatttta ttttctgatg aaaggctgta tgaaaatacc   6840

ctcctcaaat aacttgctta actacatata gattcaagtg tgtcaatatt ctattttgta   6900

tattaaatgc tatataatgg ggacaaatct atattatact gtgtatggca ttattaagaa   6960

gctttttcat tattttttat cacagtaatt ttaaaatgtg taaaaattaa aaccagtgac   7020

tcctgtttaa aaataaaagt tgtagttttt tattcatgct gaataataat ctgtagttaa   7080

aaaaaaagtg tctttttacc tacgcagtga aatgtcagac tgtaaaacct tgtgtggaaa   7140

tgtttaactt ttattttttc atttaaattt gctgttctgg tattaccaaa ccacacattt   7200

gtaccgaatt ggcagtaaat gttagccatt tacagcaatg ccaaatatgg agaaacatca   7260

taataaaaaa atctgctttt tcatta                                        7286


<210>  2273
<211>  777
<212>  PRT
<213>  Homo sapiens

<400>  2273


Met Asp Ser Lys Glu Ser Leu Thr Pro Gly Arg Glu Glu Asn Pro Ser 
1               5                   10                  15      


Ser Val Leu Ala Gln Glu Arg Gly Asp Val Met Asp Phe Tyr Lys Thr 
            20                  25                  30          


Leu Arg Gly Gly Ala Thr Val Lys Val Ser Ala Ser Ser Pro Ser Leu 
        35                  40                  45              


Ala Val Ala Ser Gln Ser Asp Ser Lys Gln Arg Arg Leu Leu Val Asp 
    50                  55                  60                  


Phe Pro Lys Gly Ser Val Ser Asn Ala Gln Gln Pro Asp Leu Ser Lys 
65                  70                  75                  80  


Ala Val Ser Leu Ser Met Gly Leu Tyr Met Gly Glu Thr Glu Thr Lys 
                85                  90                  95      


Val Met Gly Asn Asp Leu Gly Phe Pro Gln Gln Gly Gln Ile Ser Leu 
            100                 105                 110         


Ser Ser Gly Glu Thr Asp Leu Lys Leu Leu Glu Glu Ser Ile Ala Asn 
        115                 120                 125             


Leu Asn Arg Ser Thr Ser Val Pro Glu Asn Pro Lys Ser Ser Ala Ser 
    130                 135                 140                 


Thr Ala Val Ser Ala Ala Pro Thr Glu Lys Glu Phe Pro Lys Thr His 
145                 150                 155                 160 


Ser Asp Val Ser Ser Glu Gln Gln His Leu Lys Gly Gln Thr Gly Thr 
                165                 170                 175     


Asn Gly Gly Asn Val Lys Leu Tyr Thr Thr Asp Gln Ser Thr Phe Asp 
            180                 185                 190         


Ile Leu Gln Asp Leu Glu Phe Ser Ser Gly Ser Pro Gly Lys Glu Thr 
        195                 200                 205             


Asn Glu Ser Pro Trp Arg Ser Asp Leu Leu Ile Asp Glu Asn Cys Leu 
    210                 215                 220                 


Leu Ser Pro Leu Ala Gly Glu Asp Asp Ser Phe Leu Leu Glu Gly Asn 
225                 230                 235                 240 


Ser Asn Glu Asp Cys Lys Pro Leu Ile Leu Pro Asp Thr Lys Pro Lys 
                245                 250                 255     


Ile Lys Asp Asn Gly Asp Leu Val Leu Ser Ser Pro Ser Asn Val Thr 
            260                 265                 270         


Leu Pro Gln Val Lys Thr Glu Lys Glu Asp Phe Ile Glu Leu Cys Thr 
        275                 280                 285             


Pro Gly Val Ile Lys Gln Glu Lys Leu Gly Thr Val Tyr Cys Gln Ala 
    290                 295                 300                 


Ser Phe Pro Gly Ala Asn Ile Ile Gly Asn Lys Met Ser Ala Ile Ser 
305                 310                 315                 320 


Val His Gly Val Ser Thr Ser Gly Gly Gln Met Tyr His Tyr Asp Met 
                325                 330                 335     


Asn Thr Ala Ser Leu Ser Gln Gln Gln Asp Gln Lys Pro Ile Phe Asn 
            340                 345                 350         


Val Ile Pro Pro Ile Pro Val Gly Ser Glu Asn Trp Asn Arg Cys Gln 
        355                 360                 365             


Gly Ser Gly Asp Asp Asn Leu Thr Ser Leu Gly Thr Leu Asn Phe Pro 
    370                 375                 380                 


Gly Arg Thr Val Phe Ser Asn Gly Tyr Ser Ser Pro Ser Met Arg Pro 
385                 390                 395                 400 


Asp Val Ser Ser Pro Pro Ser Ser Ser Ser Thr Ala Thr Thr Gly Pro 
                405                 410                 415     


Pro Pro Lys Leu Cys Leu Val Cys Ser Asp Glu Ala Ser Gly Cys His 
            420                 425                 430         


Tyr Gly Val Leu Thr Cys Gly Ser Cys Lys Val Phe Phe Lys Arg Ala 
        435                 440                 445             


Val Glu Gly Gln His Asn Tyr Leu Cys Ala Gly Arg Asn Asp Cys Ile 
    450                 455                 460                 


Ile Asp Lys Ile Arg Arg Lys Asn Cys Pro Ala Cys Arg Tyr Arg Lys 
465                 470                 475                 480 


Cys Leu Gln Ala Gly Met Asn Leu Glu Ala Arg Lys Thr Lys Lys Lys 
                485                 490                 495     


Ile Lys Gly Ile Gln Gln Ala Thr Thr Gly Val Ser Gln Glu Thr Ser 
            500                 505                 510         


Glu Asn Pro Gly Asn Lys Thr Ile Val Pro Ala Thr Leu Pro Gln Leu 
        515                 520                 525             


Thr Pro Thr Leu Val Ser Leu Leu Glu Val Ile Glu Pro Glu Val Leu 
    530                 535                 540                 


Tyr Ala Gly Tyr Asp Ser Ser Val Pro Asp Ser Thr Trp Arg Ile Met 
545                 550                 555                 560 


Thr Thr Leu Asn Met Leu Gly Gly Arg Gln Val Ile Ala Ala Val Lys 
                565                 570                 575     


Trp Ala Lys Ala Ile Pro Gly Phe Arg Asn Leu His Leu Asp Asp Gln 
            580                 585                 590         


Met Thr Leu Leu Gln Tyr Ser Trp Met Phe Leu Met Ala Phe Ala Leu 
        595                 600                 605             


Gly Trp Arg Ser Tyr Arg Gln Ser Ser Ala Asn Leu Leu Cys Phe Ala 
    610                 615                 620                 


Pro Asp Leu Ile Ile Asn Glu Gln Arg Met Thr Leu Pro Cys Met Tyr 
625                 630                 635                 640 


Asp Gln Cys Lys His Met Leu Tyr Val Ser Ser Glu Leu His Arg Leu 
                645                 650                 655     


Gln Val Ser Tyr Glu Glu Tyr Leu Cys Met Lys Thr Leu Leu Leu Leu 
            660                 665                 670         


Ser Ser Val Pro Lys Asp Gly Leu Lys Ser Gln Glu Leu Phe Asp Glu 
        675                 680                 685             


Ile Arg Met Thr Tyr Ile Lys Glu Leu Gly Lys Ala Ile Val Lys Arg 
    690                 695                 700                 


Glu Gly Asn Ser Ser Gln Asn Trp Gln Arg Phe Tyr Gln Leu Thr Lys 
705                 710                 715                 720 


Leu Leu Asp Ser Met His Glu Val Val Glu Asn Leu Leu Asn Tyr Cys 
                725                 730                 735     


Phe Gln Thr Phe Leu Asp Lys Thr Met Ser Ile Glu Phe Pro Glu Met 
            740                 745                 750         


Leu Ala Glu Ile Ile Thr Asn Gln Ile Pro Lys Tyr Ser Asn Gly Asn 
        755                 760                 765             


Ile Lys Lys Leu Leu Phe His Gln Lys 
    770                 775         

<210>  2274
<211>  6517
<212>  DNA
<213>  Homo sapiens

<400>  2274
aggttatgta agggtttgct ttcaccccat tcaaaaggta cctcttcctc ttctcttgct     60

ccctctcgcc ctcattcttg tgcctatgca gacatttgag tagaggcgaa tcactttcac    120

ttctgctggg gaaattgcaa cacgcttctt taaatggcag agagaaggag aaaacttaga    180

tcttctgata ccaaatcact ggaccttaga agttgatatt cactgatgga ctccaaagaa    240

tcattaactc ctggtagaga agaaaacccc agcagtgtgc ttgctcagga gaggggagat    300

gtgatggact tctataaaac cctaagagga ggagctactg tgaaggtttc tgcgtcttca    360

ccctcactgg ctgtcgcttc tcaatcagac tccaagcagc gaagactttt ggttgatttt    420

ccaaaaggct cagtaagcaa tgcgcagcag ccagatctgt ccaaagcagt ttcactctca    480

atgggactgt atatgggaga gacagaaaca aaagtgatgg gaaatgacct gggattccca    540

cagcagggcc aaatcagcct ttcctcgggg gaaacagact taaagctttt ggaagaaagc    600

attgcaaacc tcaataggtc gaccagtgtt ccagagaacc ccaagagttc agcatccact    660

gctgtgtctg ctgcccccac agagaaggag tttccaaaaa ctcactctga tgtatcttca    720

gaacagcaac atttgaaggg ccagactggc accaacggtg gcaatgtgaa attgtatacc    780

acagaccaaa gcacctttga cattttgcag gatttggagt tttcttctgg gtccccaggt    840

aaagagacga atgagagtcc ttggagatca gacctgttga tagatgaaaa ctgtttgctt    900

tctcctctgg cgggagaaga cgattcattc cttttggaag gaaactcgaa tgaggactgc    960

aagcctctca ttttaccgga cactaaaccc aaaattaagg ataatggaga tctggttttg   1020

tcaagcccca gtaatgtaac actgccccaa gtgaaaacag aaaaagaaga tttcatcgaa   1080

ctctgcaccc ctggggtaat taagcaagag aaactgggca cagtttactg tcaggcaagc   1140

tttcctggag caaatataat tggtaataaa atgtctgcca tttctgttca tggtgtgagt   1200

acctctggag gacagatgta ccactatgac atgaatacag catccctttc tcaacagcag   1260

gatcagaagc ctatttttaa tgtcattcca ccaattcccg ttggttccga aaattggaat   1320

aggtgccaag gatctggaga tgacaacttg acttctctgg ggactctgaa cttccctggt   1380

cgaacagttt tttctaatgg ctattcaagc cccagcatga gaccagatgt aagctctcct   1440

ccatccagct cctcaacagc aacaacagga ccacctccca aactctgcct ggtgtgctct   1500

gatgaagctt caggatgtca ttatggagtc ttaacttgtg gaagctgtaa agttttcttc   1560

aaaagagcag tggaaggaca gcacaattac ctatgtgctg gaaggaatga ttgcatcatc   1620

gataaaattc gaagaaaaaa ctgcccagca tgccgctatc gaaaatgtct tcaggctgga   1680

atgaacctgg aagctcgaaa aacaaagaaa aaaataaaag gaattcagca ggccactaca   1740

ggagtctcac aagaaacctc tgaaaatcct ggtaacaaaa caatagttcc tgcaacgtta   1800

ccacaactca cccctaccct ggtgtcactg ttggaggtta ttgaacctga agtgttatat   1860

gcaggatatg atagctctgt tccagactca acttggagga tcatgactac gctcaacatg   1920

ttaggagggc ggcaagtgat tgcagcagtg aaatgggcaa aggcaatacc aggtttcagg   1980

aacttacacc tggatgacca aatgacccta ctgcagtact cctggatgtt tcttatggca   2040

tttgctctgg ggtggagatc atatagacaa tcaagtgcaa acctgctgtg ttttgctcct   2100

gatctgatta ttaatgagca gagaatgact ctaccctgca tgtacgacca atgtaaacac   2160

atgctgtatg tttcctctga gttacacagg cttcaggtat cttatgaaga gtatctctgt   2220

atgaaaacct tactgcttct ctcttcagtt cctaaggacg gtctgaagag ccaagagcta   2280

tttgatgaaa ttagaatgac ctacatcaaa gagctaggaa aagccattgt caagagggaa   2340

ggaaactcca gccagaactg gcagcggttt tatcaactga caaaactctt ggattctatg   2400

catgaagtgg ttgaaaatct ccttaactat tgcttccaaa catttttgga taagaccatg   2460

agtattgaat tccccgagat gttagctgaa atcatcacca atcagatacc aaaatattca   2520

aatggaaata tcaaaaaact tctgtttcat caaaagtgac tgccttaata agaatggttg   2580

ccttaaagaa agtcgaatta atagctttta ttgtataaac tatcagtttg tcctgtagag   2640

gttttgttgt tttatttttt attgttttca tctgttgttt tgttttaaat acgcactaca   2700

tgtggtttat agagggccaa gacttggcaa cagaagcagt tgagtcgtca tcacttttca   2760

gtgatgggag agtagatggt gaaatttatt agttaatata tcccagaaat tagaaacctt   2820

aatatgtgga cgtaatctcc acagtcaaag aaggatggca cctaaaccac cagtgcccaa   2880

agtctgtgtg atgaactttc tcttcatact ttttttcaca gttggctgga tgaaattttc   2940

tagactttct gttggtgtat cccccccctg tatagttagg atagcatttt tgatttatgc   3000

atggaaacct gaaaaaaagt ttacaagtgt atatcagaaa agggaagttg tgccttttat   3060

agctattact gtctggtttt aacaatttcc tttatattta gtgaactacg cttgctcatt   3120

ttttcttaca taatttttta ttcaagttat tgtacagctg tttaagatgg gcagctagtt   3180

cgtagctttc ccaaataaac tctaaacatt aatcaatcat ctgtgtgaaa atgggttggt   3240

gcttctaacc tgatggcact tagctatcag aagaccacaa aaattgactc aaatctccag   3300

tattcttgtc aaaaaaaaaa aaaaaaaagc tcatattttg tatatatctg cttcagtgga   3360

gaattatata ggttgtgcaa attaacagtc ctaactggta tagagcacct agtccagtga   3420

cctgctgggt aaactgtgga tgatggttgc aaaagactaa tttaaaaaat aactaccaag   3480

aggccctgtc tgtacctaac gccctatttt tgcaatggct atatggcaag aaagctggta   3540

aactatttgt ctttcaggac cttttgaagt agtttgtata acttcttaaa agttgtgatt   3600

ccagataacc agctgtaaca cagctgagag acttttaatc agacaaagta attcctctca   3660

ctaaacttta cccaaaaact aaatctctaa tatggcaaaa atggctagac acccattttc   3720

acattcccat ctgtcaccaa ttggttaatc tttcctgatg gtacaggaaa gctcagctac   3780

tgatttttgt gatttagaac tgtatgtcag acatccatgt ttgtaaaact acacatccct   3840

aatgtgtgcc atagagttta acacaagtcc tgtgaatttc ttcactgttg aaaattattt   3900

taaacaaaat agaagctgta gtagcccttt ctgtgtgcac cttaccaact ttctgtaaac   3960

tcaaaactta acatatttac taagccacaa gaaatttgat ttctattcaa ggtggccaaa   4020

ttatttgtgt aatagaaaac tgaaaatcta atattaaaaa tatggaactt ctaatatatt   4080

tttatattta gttatagttt cagatatata tcatattggt attcactaat ctgggaaggg   4140

aagggctact gcagctttac atgcaattta ttaaaatgat tgtaaaatag cttgtatagt   4200

gtaaaataag aatgattttt agatgagatt gttttatcat gacatgttat atattttttg   4260

taggggtcaa agaaatgctg atggataacc tatatgattt atagtttgta catgcattca   4320

tacaggcagc gatggtctca gaaaccaaac agtttgctct aggggaagag ggagatggag   4380

actggtcctg tgtgcagtga aggttgctga ggctctgacc cagtgagatt acagaggaag   4440

ttatcctctg cctcccattc tgaccaccct tctcattcca acagtgagtc tgtcagcgca   4500

ggtttagttt actcaatctc cccttgcact aaagtatgta aagtatgtaa acaggagaca   4560

ggaaggtggt gcttacatcc ttaaaggcac catctaatag cgggttactt tcacatacag   4620

ccctccccca gcagttgaat gacaacagaa gcttcagaag tttggcaata gtttgcatag   4680

aggtaccagc aatatgtaaa tagtgcagaa tctcataggt tgccaataat acactaattc   4740

ctttctatcc tacaacaaga gtttatttcc aaataaaatg aggacatgtt tttgttttct   4800

ttgaatgctt tttgaatgtt atttgttatt ttcagtattt tggagaaatt atttaataaa   4860

aaaacaatca tttgcttttt gaatgctctc taaaagggaa tgtaatattt taagatggtg   4920

tgtaacccgg ctggataaat ttttggtgcc taagaaaact gcttgaatat tcttatcaat   4980

gacagtgtta agtttcaaaa agagcttcta aaacgtagat tatcattcct ttatagaatg   5040

ttatgtggtt aaaaccagaa agcacatctc acacattaat ctgattttca tcccaacaat   5100

cttggcgctc aaaaaataga actcaatgag aaaaagaaga ttatgtgcac ttcgttgtca   5160

ataataagtc aactgatgct catcgacaac tataggaggc ttttcattaa atgggaaaag   5220

aagctgtgcc cttttaggat acgtggggga aaagaaagtc atcttaatta tgtttaattg   5280

tggatttaag tgctatatgg tggtgctgtt tgaaagcaga tttatttcct atgtatgtgt   5340

tatctggcca tcccaaccca aactgttgaa gtttgtagta acttcagtga gagttggtta   5400

ctcacaacaa atcctgaaaa gtatttttag tgtttgtagg tattctgtgg gatactatac   5460

aagcagaact gaggcactta ggacataaca cttttggggt atatatatcc aaatgcctaa   5520

aactatggga ggaaaccttg gccaccccaa aaggaaaact aacatgattt gtgtctatga   5580

agtgctggat aattagcatg ggatgagctc tgggcatgcc atgaaggaaa gccacgctcc   5640

cttcagaatt cagaggcagg gagcaattcc agtttcacct aagtctcata attttagttc   5700

ccttttaaaa accctgaaaa ctacatcacc atggaatgaa aaatattgtt atacaataca   5760

ttgatctgtc aaacttccag aaccatggta gccttcagtg agatttccat cttggctggt   5820

cactccctga ctgtagctgt aggtgaatgt gtttttgtgt gtgtgtgtct ggttttagtg   5880

tcagaaggga aataaaagtg taaggaggac actttaaacc ctttgggtgg agtttcgtaa   5940

tttcccagac tattttcaag caacctggtc cacccaggat tagtgaccag gttttcagga   6000

aaggatttgc ttctctctag aaaatgtctg aaaggatttt attttctgat gaaaggctgt   6060

atgaaaatac cctcctcaaa taacttgctt aactacatat agattcaagt gtgtcaatat   6120

tctattttgt atattaaatg ctatataatg gggacaaatc tatattatac tgtgtatggc   6180

attattaaga agctttttca ttatttttta tcacagtaat tttaaaatgt gtaaaaatta   6240

aaaccagtga ctcctgttta aaaataaaag ttgtagtttt ttattcatgc tgaataataa   6300

tctgtagtta aaaaaaaagt gtctttttac ctacgcagtg aaatgtcaga ctgtaaaacc   6360

ttgtgtggaa atgtttaact tttatttttt catttaaatt tgctgttctg gtattaccaa   6420

accacacatt tgtaccgaat tggcagtaaa tgttagccat ttacagcaat gccaaatatg   6480

gagaaacatc ataataaaaa aatctgcttt ttcatta                            6517


<210>  2275
<211>  777
<212>  PRT
<213>  Homo sapiens

<400>  2275


Met Asp Ser Lys Glu Ser Leu Thr Pro Gly Arg Glu Glu Asn Pro Ser 
1               5                   10                  15      


Ser Val Leu Ala Gln Glu Arg Gly Asp Val Met Asp Phe Tyr Lys Thr 
            20                  25                  30          


Leu Arg Gly Gly Ala Thr Val Lys Val Ser Ala Ser Ser Pro Ser Leu 
        35                  40                  45              


Ala Val Ala Ser Gln Ser Asp Ser Lys Gln Arg Arg Leu Leu Val Asp 
    50                  55                  60                  


Phe Pro Lys Gly Ser Val Ser Asn Ala Gln Gln Pro Asp Leu Ser Lys 
65                  70                  75                  80  


Ala Val Ser Leu Ser Met Gly Leu Tyr Met Gly Glu Thr Glu Thr Lys 
                85                  90                  95      


Val Met Gly Asn Asp Leu Gly Phe Pro Gln Gln Gly Gln Ile Ser Leu 
            100                 105                 110         


Ser Ser Gly Glu Thr Asp Leu Lys Leu Leu Glu Glu Ser Ile Ala Asn 
        115                 120                 125             


Leu Asn Arg Ser Thr Ser Val Pro Glu Asn Pro Lys Ser Ser Ala Ser 
    130                 135                 140                 


Thr Ala Val Ser Ala Ala Pro Thr Glu Lys Glu Phe Pro Lys Thr His 
145                 150                 155                 160 


Ser Asp Val Ser Ser Glu Gln Gln His Leu Lys Gly Gln Thr Gly Thr 
                165                 170                 175     


Asn Gly Gly Asn Val Lys Leu Tyr Thr Thr Asp Gln Ser Thr Phe Asp 
            180                 185                 190         


Ile Leu Gln Asp Leu Glu Phe Ser Ser Gly Ser Pro Gly Lys Glu Thr 
        195                 200                 205             


Asn Glu Ser Pro Trp Arg Ser Asp Leu Leu Ile Asp Glu Asn Cys Leu 
    210                 215                 220                 


Leu Ser Pro Leu Ala Gly Glu Asp Asp Ser Phe Leu Leu Glu Gly Asn 
225                 230                 235                 240 


Ser Asn Glu Asp Cys Lys Pro Leu Ile Leu Pro Asp Thr Lys Pro Lys 
                245                 250                 255     


Ile Lys Asp Asn Gly Asp Leu Val Leu Ser Ser Pro Ser Asn Val Thr 
            260                 265                 270         


Leu Pro Gln Val Lys Thr Glu Lys Glu Asp Phe Ile Glu Leu Cys Thr 
        275                 280                 285             


Pro Gly Val Ile Lys Gln Glu Lys Leu Gly Thr Val Tyr Cys Gln Ala 
    290                 295                 300                 


Ser Phe Pro Gly Ala Asn Ile Ile Gly Asn Lys Met Ser Ala Ile Ser 
305                 310                 315                 320 


Val His Gly Val Ser Thr Ser Gly Gly Gln Met Tyr His Tyr Asp Met 
                325                 330                 335     


Asn Thr Ala Ser Leu Ser Gln Gln Gln Asp Gln Lys Pro Ile Phe Asn 
            340                 345                 350         


Val Ile Pro Pro Ile Pro Val Gly Ser Glu Asn Trp Asn Arg Cys Gln 
        355                 360                 365             


Gly Ser Gly Asp Asp Asn Leu Thr Ser Leu Gly Thr Leu Asn Phe Pro 
    370                 375                 380                 


Gly Arg Thr Val Phe Ser Asn Gly Tyr Ser Ser Pro Ser Met Arg Pro 
385                 390                 395                 400 


Asp Val Ser Ser Pro Pro Ser Ser Ser Ser Thr Ala Thr Thr Gly Pro 
                405                 410                 415     


Pro Pro Lys Leu Cys Leu Val Cys Ser Asp Glu Ala Ser Gly Cys His 
            420                 425                 430         


Tyr Gly Val Leu Thr Cys Gly Ser Cys Lys Val Phe Phe Lys Arg Ala 
        435                 440                 445             


Val Glu Gly Gln His Asn Tyr Leu Cys Ala Gly Arg Asn Asp Cys Ile 
    450                 455                 460                 


Ile Asp Lys Ile Arg Arg Lys Asn Cys Pro Ala Cys Arg Tyr Arg Lys 
465                 470                 475                 480 


Cys Leu Gln Ala Gly Met Asn Leu Glu Ala Arg Lys Thr Lys Lys Lys 
                485                 490                 495     


Ile Lys Gly Ile Gln Gln Ala Thr Thr Gly Val Ser Gln Glu Thr Ser 
            500                 505                 510         


Glu Asn Pro Gly Asn Lys Thr Ile Val Pro Ala Thr Leu Pro Gln Leu 
        515                 520                 525             


Thr Pro Thr Leu Val Ser Leu Leu Glu Val Ile Glu Pro Glu Val Leu 
    530                 535                 540                 


Tyr Ala Gly Tyr Asp Ser Ser Val Pro Asp Ser Thr Trp Arg Ile Met 
545                 550                 555                 560 


Thr Thr Leu Asn Met Leu Gly Gly Arg Gln Val Ile Ala Ala Val Lys 
                565                 570                 575     


Trp Ala Lys Ala Ile Pro Gly Phe Arg Asn Leu His Leu Asp Asp Gln 
            580                 585                 590         


Met Thr Leu Leu Gln Tyr Ser Trp Met Phe Leu Met Ala Phe Ala Leu 
        595                 600                 605             


Gly Trp Arg Ser Tyr Arg Gln Ser Ser Ala Asn Leu Leu Cys Phe Ala 
    610                 615                 620                 


Pro Asp Leu Ile Ile Asn Glu Gln Arg Met Thr Leu Pro Cys Met Tyr 
625                 630                 635                 640 


Asp Gln Cys Lys His Met Leu Tyr Val Ser Ser Glu Leu His Arg Leu 
                645                 650                 655     


Gln Val Ser Tyr Glu Glu Tyr Leu Cys Met Lys Thr Leu Leu Leu Leu 
            660                 665                 670         


Ser Ser Val Pro Lys Asp Gly Leu Lys Ser Gln Glu Leu Phe Asp Glu 
        675                 680                 685             


Ile Arg Met Thr Tyr Ile Lys Glu Leu Gly Lys Ala Ile Val Lys Arg 
    690                 695                 700                 


Glu Gly Asn Ser Ser Gln Asn Trp Gln Arg Phe Tyr Gln Leu Thr Lys 
705                 710                 715                 720 


Leu Leu Asp Ser Met His Glu Val Val Glu Asn Leu Leu Asn Tyr Cys 
                725                 730                 735     


Phe Gln Thr Phe Leu Asp Lys Thr Met Ser Ile Glu Phe Pro Glu Met 
            740                 745                 750         


Leu Ala Glu Ile Ile Thr Asn Gln Ile Pro Lys Tyr Ser Asn Gly Asn 
        755                 760                 765             


Ile Lys Lys Leu Leu Phe His Gln Lys 
    770                 775         

<210>  2276
<211>  6614
<212>  DNA
<213>  Homo sapiens

<400>  2276
aggttatgta agggtttgct ttcaccccat tcaaaaggta cctcttcctc ttctcttgct     60

ccctctcgcc ctcattcttg tgcctatgca gacatttgag tagaggcgaa tcactttcac    120

ttctgctggg gaaattgcaa cacgcttctt taaatggcag agagaaggag aaaacttaga    180

tcttctgata ccaaatcact ggaccttaga aggtcagaaa tctttcaagc cctgcaggac    240

cgtaaaatgc gcatgtgtcc aacggaagca ctggggcatg agtggggaag gaatagaaac    300

agaaagaggt tgatattcac tgatggactc caaagaatca ttaactcctg gtagagaaga    360

aaaccccagc agtgtgcttg ctcaggagag gggagatgtg atggacttct ataaaaccct    420

aagaggagga gctactgtga aggtttctgc gtcttcaccc tcactggctg tcgcttctca    480

atcagactcc aagcagcgaa gacttttggt tgattttcca aaaggctcag taagcaatgc    540

gcagcagcca gatctgtcca aagcagtttc actctcaatg ggactgtata tgggagagac    600

agaaacaaaa gtgatgggaa atgacctggg attcccacag cagggccaaa tcagcctttc    660

ctcgggggaa acagacttaa agcttttgga agaaagcatt gcaaacctca ataggtcgac    720

cagtgttcca gagaacccca agagttcagc atccactgct gtgtctgctg cccccacaga    780

gaaggagttt ccaaaaactc actctgatgt atcttcagaa cagcaacatt tgaagggcca    840

gactggcacc aacggtggca atgtgaaatt gtataccaca gaccaaagca cctttgacat    900

tttgcaggat ttggagtttt cttctgggtc cccaggtaaa gagacgaatg agagtccttg    960

gagatcagac ctgttgatag atgaaaactg tttgctttct cctctggcgg gagaagacga   1020

ttcattcctt ttggaaggaa actcgaatga ggactgcaag cctctcattt taccggacac   1080

taaacccaaa attaaggata atggagatct ggttttgtca agccccagta atgtaacact   1140

gccccaagtg aaaacagaaa aagaagattt catcgaactc tgcacccctg gggtaattaa   1200

gcaagagaaa ctgggcacag tttactgtca ggcaagcttt cctggagcaa atataattgg   1260

taataaaatg tctgccattt ctgttcatgg tgtgagtacc tctggaggac agatgtacca   1320

ctatgacatg aatacagcat ccctttctca acagcaggat cagaagccta tttttaatgt   1380

cattccacca attcccgttg gttccgaaaa ttggaatagg tgccaaggat ctggagatga   1440

caacttgact tctctgggga ctctgaactt ccctggtcga acagtttttt ctaatggcta   1500

ttcaagcccc agcatgagac cagatgtaag ctctcctcca tccagctcct caacagcaac   1560

aacaggacca cctcccaaac tctgcctggt gtgctctgat gaagcttcag gatgtcatta   1620

tggagtctta acttgtggaa gctgtaaagt tttcttcaaa agagcagtgg aaggacagca   1680

caattaccta tgtgctggaa ggaatgattg catcatcgat aaaattcgaa gaaaaaactg   1740

cccagcatgc cgctatcgaa aatgtcttca ggctggaatg aacctggaag ctcgaaaaac   1800

aaagaaaaaa ataaaaggaa ttcagcaggc cactacagga gtctcacaag aaacctctga   1860

aaatcctggt aacaaaacaa tagttcctgc aacgttacca caactcaccc ctaccctggt   1920

gtcactgttg gaggttattg aacctgaagt gttatatgca ggatatgata gctctgttcc   1980

agactcaact tggaggatca tgactacgct caacatgtta ggagggcggc aagtgattgc   2040

agcagtgaaa tgggcaaagg caataccagg tttcaggaac ttacacctgg atgaccaaat   2100

gaccctactg cagtactcct ggatgtttct tatggcattt gctctggggt ggagatcata   2160

tagacaatca agtgcaaacc tgctgtgttt tgctcctgat ctgattatta atgagcagag   2220

aatgactcta ccctgcatgt acgaccaatg taaacacatg ctgtatgttt cctctgagtt   2280

acacaggctt caggtatctt atgaagagta tctctgtatg aaaaccttac tgcttctctc   2340

ttcagttcct aaggacggtc tgaagagcca agagctattt gatgaaatta gaatgaccta   2400

catcaaagag ctaggaaaag ccattgtcaa gagggaagga aactccagcc agaactggca   2460

gcggttttat caactgacaa aactcttgga ttctatgcat gaagtggttg aaaatctcct   2520

taactattgc ttccaaacat ttttggataa gaccatgagt attgaattcc ccgagatgtt   2580

agctgaaatc atcaccaatc agataccaaa atattcaaat ggaaatatca aaaaacttct   2640

gtttcatcaa aagtgactgc cttaataaga atggttgcct taaagaaagt cgaattaata   2700

gcttttattg tataaactat cagtttgtcc tgtagaggtt ttgttgtttt attttttatt   2760

gttttcatct gttgttttgt tttaaatacg cactacatgt ggtttataga gggccaagac   2820

ttggcaacag aagcagttga gtcgtcatca cttttcagtg atgggagagt agatggtgaa   2880

atttattagt taatatatcc cagaaattag aaaccttaat atgtggacgt aatctccaca   2940

gtcaaagaag gatggcacct aaaccaccag tgcccaaagt ctgtgtgatg aactttctct   3000

tcatactttt tttcacagtt ggctggatga aattttctag actttctgtt ggtgtatccc   3060

ccccctgtat agttaggata gcatttttga tttatgcatg gaaacctgaa aaaaagttta   3120

caagtgtata tcagaaaagg gaagttgtgc cttttatagc tattactgtc tggttttaac   3180

aatttccttt atatttagtg aactacgctt gctcattttt tcttacataa ttttttattc   3240

aagttattgt acagctgttt aagatgggca gctagttcgt agctttccca aataaactct   3300

aaacattaat caatcatctg tgtgaaaatg ggttggtgct tctaacctga tggcacttag   3360

ctatcagaag accacaaaaa ttgactcaaa tctccagtat tcttgtcaaa aaaaaaaaaa   3420

aaaaagctca tattttgtat atatctgctt cagtggagaa ttatataggt tgtgcaaatt   3480

aacagtccta actggtatag agcacctagt ccagtgacct gctgggtaaa ctgtggatga   3540

tggttgcaaa agactaattt aaaaaataac taccaagagg ccctgtctgt acctaacgcc   3600

ctatttttgc aatggctata tggcaagaaa gctggtaaac tatttgtctt tcaggacctt   3660

ttgaagtagt ttgtataact tcttaaaagt tgtgattcca gataaccagc tgtaacacag   3720

ctgagagact tttaatcaga caaagtaatt cctctcacta aactttaccc aaaaactaaa   3780

tctctaatat ggcaaaaatg gctagacacc cattttcaca ttcccatctg tcaccaattg   3840

gttaatcttt cctgatggta caggaaagct cagctactga tttttgtgat ttagaactgt   3900

atgtcagaca tccatgtttg taaaactaca catccctaat gtgtgccata gagtttaaca   3960

caagtcctgt gaatttcttc actgttgaaa attattttaa acaaaataga agctgtagta   4020

gccctttctg tgtgcacctt accaactttc tgtaaactca aaacttaaca tatttactaa   4080

gccacaagaa atttgatttc tattcaaggt ggccaaatta tttgtgtaat agaaaactga   4140

aaatctaata ttaaaaatat ggaacttcta atatattttt atatttagtt atagtttcag   4200

atatatatca tattggtatt cactaatctg ggaagggaag ggctactgca gctttacatg   4260

caatttatta aaatgattgt aaaatagctt gtatagtgta aaataagaat gatttttaga   4320

tgagattgtt ttatcatgac atgttatata ttttttgtag gggtcaaaga aatgctgatg   4380

gataacctat atgatttata gtttgtacat gcattcatac aggcagcgat ggtctcagaa   4440

accaaacagt ttgctctagg ggaagaggga gatggagact ggtcctgtgt gcagtgaagg   4500

ttgctgaggc tctgacccag tgagattaca gaggaagtta tcctctgcct cccattctga   4560

ccacccttct cattccaaca gtgagtctgt cagcgcaggt ttagtttact caatctcccc   4620

ttgcactaaa gtatgtaaag tatgtaaaca ggagacagga aggtggtgct tacatcctta   4680

aaggcaccat ctaatagcgg gttactttca catacagccc tcccccagca gttgaatgac   4740

aacagaagct tcagaagttt ggcaatagtt tgcatagagg taccagcaat atgtaaatag   4800

tgcagaatct cataggttgc caataataca ctaattcctt tctatcctac aacaagagtt   4860

tatttccaaa taaaatgagg acatgttttt gttttctttg aatgcttttt gaatgttatt   4920

tgttattttc agtattttgg agaaattatt taataaaaaa acaatcattt gctttttgaa   4980

tgctctctaa aagggaatgt aatattttaa gatggtgtgt aacccggctg gataaatttt   5040

tggtgcctaa gaaaactgct tgaatattct tatcaatgac agtgttaagt ttcaaaaaga   5100

gcttctaaaa cgtagattat cattccttta tagaatgtta tgtggttaaa accagaaagc   5160

acatctcaca cattaatctg attttcatcc caacaatctt ggcgctcaaa aaatagaact   5220

caatgagaaa aagaagatta tgtgcacttc gttgtcaata ataagtcaac tgatgctcat   5280

cgacaactat aggaggcttt tcattaaatg ggaaaagaag ctgtgccctt ttaggatacg   5340

tgggggaaaa gaaagtcatc ttaattatgt ttaattgtgg atttaagtgc tatatggtgg   5400

tgctgtttga aagcagattt atttcctatg tatgtgttat ctggccatcc caacccaaac   5460

tgttgaagtt tgtagtaact tcagtgagag ttggttactc acaacaaatc ctgaaaagta   5520

tttttagtgt ttgtaggtat tctgtgggat actatacaag cagaactgag gcacttagga   5580

cataacactt ttggggtata tatatccaaa tgcctaaaac tatgggagga aaccttggcc   5640

accccaaaag gaaaactaac atgatttgtg tctatgaagt gctggataat tagcatggga   5700

tgagctctgg gcatgccatg aaggaaagcc acgctccctt cagaattcag aggcagggag   5760

caattccagt ttcacctaag tctcataatt ttagttccct tttaaaaacc ctgaaaacta   5820

catcaccatg gaatgaaaaa tattgttata caatacattg atctgtcaaa cttccagaac   5880

catggtagcc ttcagtgaga tttccatctt ggctggtcac tccctgactg tagctgtagg   5940

tgaatgtgtt tttgtgtgtg tgtgtctggt tttagtgtca gaagggaaat aaaagtgtaa   6000

ggaggacact ttaaaccctt tgggtggagt ttcgtaattt cccagactat tttcaagcaa   6060

cctggtccac ccaggattag tgaccaggtt ttcaggaaag gatttgcttc tctctagaaa   6120

atgtctgaaa ggattttatt ttctgatgaa aggctgtatg aaaataccct cctcaaataa   6180

cttgcttaac tacatataga ttcaagtgtg tcaatattct attttgtata ttaaatgcta   6240

tataatgggg acaaatctat attatactgt gtatggcatt attaagaagc tttttcatta   6300

ttttttatca cagtaatttt aaaatgtgta aaaattaaaa ccagtgactc ctgtttaaaa   6360

ataaaagttg tagtttttta ttcatgctga ataataatct gtagttaaaa aaaaagtgtc   6420

tttttaccta cgcagtgaaa tgtcagactg taaaaccttg tgtggaaatg tttaactttt   6480

attttttcat ttaaatttgc tgttctggta ttaccaaacc acacatttgt accgaattgg   6540

cagtaaatgt tagccattta cagcaatgcc aaatatggag aaacatcata ataaaaaaat   6600

ctgctttttc atta                                                     6614


<210>  2277
<211>  777
<212>  PRT
<213>  Homo sapiens

<400>  2277


Met Asp Ser Lys Glu Ser Leu Thr Pro Gly Arg Glu Glu Asn Pro Ser 
1               5                   10                  15      


Ser Val Leu Ala Gln Glu Arg Gly Asp Val Met Asp Phe Tyr Lys Thr 
            20                  25                  30          


Leu Arg Gly Gly Ala Thr Val Lys Val Ser Ala Ser Ser Pro Ser Leu 
        35                  40                  45              


Ala Val Ala Ser Gln Ser Asp Ser Lys Gln Arg Arg Leu Leu Val Asp 
    50                  55                  60                  


Phe Pro Lys Gly Ser Val Ser Asn Ala Gln Gln Pro Asp Leu Ser Lys 
65                  70                  75                  80  


Ala Val Ser Leu Ser Met Gly Leu Tyr Met Gly Glu Thr Glu Thr Lys 
                85                  90                  95      


Val Met Gly Asn Asp Leu Gly Phe Pro Gln Gln Gly Gln Ile Ser Leu 
            100                 105                 110         


Ser Ser Gly Glu Thr Asp Leu Lys Leu Leu Glu Glu Ser Ile Ala Asn 
        115                 120                 125             


Leu Asn Arg Ser Thr Ser Val Pro Glu Asn Pro Lys Ser Ser Ala Ser 
    130                 135                 140                 


Thr Ala Val Ser Ala Ala Pro Thr Glu Lys Glu Phe Pro Lys Thr His 
145                 150                 155                 160 


Ser Asp Val Ser Ser Glu Gln Gln His Leu Lys Gly Gln Thr Gly Thr 
                165                 170                 175     


Asn Gly Gly Asn Val Lys Leu Tyr Thr Thr Asp Gln Ser Thr Phe Asp 
            180                 185                 190         


Ile Leu Gln Asp Leu Glu Phe Ser Ser Gly Ser Pro Gly Lys Glu Thr 
        195                 200                 205             


Asn Glu Ser Pro Trp Arg Ser Asp Leu Leu Ile Asp Glu Asn Cys Leu 
    210                 215                 220                 


Leu Ser Pro Leu Ala Gly Glu Asp Asp Ser Phe Leu Leu Glu Gly Asn 
225                 230                 235                 240 


Ser Asn Glu Asp Cys Lys Pro Leu Ile Leu Pro Asp Thr Lys Pro Lys 
                245                 250                 255     


Ile Lys Asp Asn Gly Asp Leu Val Leu Ser Ser Pro Ser Asn Val Thr 
            260                 265                 270         


Leu Pro Gln Val Lys Thr Glu Lys Glu Asp Phe Ile Glu Leu Cys Thr 
        275                 280                 285             


Pro Gly Val Ile Lys Gln Glu Lys Leu Gly Thr Val Tyr Cys Gln Ala 
    290                 295                 300                 


Ser Phe Pro Gly Ala Asn Ile Ile Gly Asn Lys Met Ser Ala Ile Ser 
305                 310                 315                 320 


Val His Gly Val Ser Thr Ser Gly Gly Gln Met Tyr His Tyr Asp Met 
                325                 330                 335     


Asn Thr Ala Ser Leu Ser Gln Gln Gln Asp Gln Lys Pro Ile Phe Asn 
            340                 345                 350         


Val Ile Pro Pro Ile Pro Val Gly Ser Glu Asn Trp Asn Arg Cys Gln 
        355                 360                 365             


Gly Ser Gly Asp Asp Asn Leu Thr Ser Leu Gly Thr Leu Asn Phe Pro 
    370                 375                 380                 


Gly Arg Thr Val Phe Ser Asn Gly Tyr Ser Ser Pro Ser Met Arg Pro 
385                 390                 395                 400 


Asp Val Ser Ser Pro Pro Ser Ser Ser Ser Thr Ala Thr Thr Gly Pro 
                405                 410                 415     


Pro Pro Lys Leu Cys Leu Val Cys Ser Asp Glu Ala Ser Gly Cys His 
            420                 425                 430         


Tyr Gly Val Leu Thr Cys Gly Ser Cys Lys Val Phe Phe Lys Arg Ala 
        435                 440                 445             


Val Glu Gly Gln His Asn Tyr Leu Cys Ala Gly Arg Asn Asp Cys Ile 
    450                 455                 460                 


Ile Asp Lys Ile Arg Arg Lys Asn Cys Pro Ala Cys Arg Tyr Arg Lys 
465                 470                 475                 480 


Cys Leu Gln Ala Gly Met Asn Leu Glu Ala Arg Lys Thr Lys Lys Lys 
                485                 490                 495     


Ile Lys Gly Ile Gln Gln Ala Thr Thr Gly Val Ser Gln Glu Thr Ser 
            500                 505                 510         


Glu Asn Pro Gly Asn Lys Thr Ile Val Pro Ala Thr Leu Pro Gln Leu 
        515                 520                 525             


Thr Pro Thr Leu Val Ser Leu Leu Glu Val Ile Glu Pro Glu Val Leu 
    530                 535                 540                 


Tyr Ala Gly Tyr Asp Ser Ser Val Pro Asp Ser Thr Trp Arg Ile Met 
545                 550                 555                 560 


Thr Thr Leu Asn Met Leu Gly Gly Arg Gln Val Ile Ala Ala Val Lys 
                565                 570                 575     


Trp Ala Lys Ala Ile Pro Gly Phe Arg Asn Leu His Leu Asp Asp Gln 
            580                 585                 590         


Met Thr Leu Leu Gln Tyr Ser Trp Met Phe Leu Met Ala Phe Ala Leu 
        595                 600                 605             


Gly Trp Arg Ser Tyr Arg Gln Ser Ser Ala Asn Leu Leu Cys Phe Ala 
    610                 615                 620                 


Pro Asp Leu Ile Ile Asn Glu Gln Arg Met Thr Leu Pro Cys Met Tyr 
625                 630                 635                 640 


Asp Gln Cys Lys His Met Leu Tyr Val Ser Ser Glu Leu His Arg Leu 
                645                 650                 655     


Gln Val Ser Tyr Glu Glu Tyr Leu Cys Met Lys Thr Leu Leu Leu Leu 
            660                 665                 670         


Ser Ser Val Pro Lys Asp Gly Leu Lys Ser Gln Glu Leu Phe Asp Glu 
        675                 680                 685             


Ile Arg Met Thr Tyr Ile Lys Glu Leu Gly Lys Ala Ile Val Lys Arg 
    690                 695                 700                 


Glu Gly Asn Ser Ser Gln Asn Trp Gln Arg Phe Tyr Gln Leu Thr Lys 
705                 710                 715                 720 


Leu Leu Asp Ser Met His Glu Val Val Glu Asn Leu Leu Asn Tyr Cys 
                725                 730                 735     


Phe Gln Thr Phe Leu Asp Lys Thr Met Ser Ile Glu Phe Pro Glu Met 
            740                 745                 750         


Leu Ala Glu Ile Ile Thr Asn Gln Ile Pro Lys Tyr Ser Asn Gly Asn 
        755                 760                 765             


Ile Lys Lys Leu Leu Phe His Gln Lys 
    770                 775         

<210>  2278
<211>  6327
<212>  DNA
<213>  Homo sapiens

<400>  2278
gataagcact taatgagtgc cttctctgtg cgagaatggg gaggaacaaa atgcagctcc     60

taccctcctc gggctttagt tgtaccttaa taacaggaat tttcatctgc ctggctcctt    120

tcctcaaaga acaaagaaga ctttgcttca ttaaagtgtc tgagaaggaa ggtttgaaca    180

ggatccctct ggctggtgtg tgaagaatta actgtagatg ggcaagtgtg gaaggaagga    240

gagcagtcag gaagctgcca taaccatcta catgagagag ttgatattca ctgatggact    300

ccaaagaatc attaactcct ggtagagaag aaaaccccag cagtgtgctt gctcaggaga    360

ggggagatgt gatggacttc tataaaaccc taagaggagg agctactgtg aaggtttctg    420

cgtcttcacc ctcactggct gtcgcttctc aatcagactc caagcagcga agacttttgg    480

ttgattttcc aaaaggctca gtaagcaatg cgcagcagcc agatctgtcc aaagcagttt    540

cactctcaat gggactgtat atgggagaga cagaaacaaa agtgatggga aatgacctgg    600

gattcccaca gcagggccaa atcagccttt cctcggggga aacagactta aagcttttgg    660

aagaaagcat tgcaaacctc aataggtcga ccagtgttcc agagaacccc aagagttcag    720

catccactgc tgtgtctgct gcccccacag agaaggagtt tccaaaaact cactctgatg    780

tatcttcaga acagcaacat ttgaagggcc agactggcac caacggtggc aatgtgaaat    840

tgtataccac agaccaaagc acctttgaca ttttgcagga tttggagttt tcttctgggt    900

ccccaggtaa agagacgaat gagagtcctt ggagatcaga cctgttgata gatgaaaact    960

gtttgctttc tcctctggcg ggagaagacg attcattcct tttggaagga aactcgaatg   1020

aggactgcaa gcctctcatt ttaccggaca ctaaacccaa aattaaggat aatggagatc   1080

tggttttgtc aagccccagt aatgtaacac tgccccaagt gaaaacagaa aaagaagatt   1140

tcatcgaact ctgcacccct ggggtaatta agcaagagaa actgggcaca gtttactgtc   1200

aggcaagctt tcctggagca aatataattg gtaataaaat gtctgccatt tctgttcatg   1260

gtgtgagtac ctctggagga cagatgtacc actatgacat gaatacagca tccctttctc   1320

aacagcagga tcagaagcct atttttaatg tcattccacc aattcccgtt ggttccgaaa   1380

attggaatag gtgccaagga tctggagatg acaacttgac ttctctgggg actctgaact   1440

tccctggtcg aacagttttt tctaatggct attcaagccc cagcatgaga ccagatgtaa   1500

gctctcctcc atccagctcc tcaacagcaa caacaggacc acctcccaaa ctctgcctgg   1560

tgtgctctga tgaagcttca ggatgtcatt atggagtctt aacttgtgga agctgtaaag   1620

ttttcttcaa aagagcagtg gaaggacagc acaattacct atgtgctgga aggaatgatt   1680

gcatcatcga taaaattcga agaaaaaact gcccagcatg ccgctatcga aaatgtcttc   1740

aggctggaat gaacctggaa gctcgaaaaa caaagaaaaa aataaaagga attcagcagg   1800

ccactacagg agtctcacaa gaaacctctg aaaatcctgg taacaaaaca atagttcctg   1860

caacgttacc acaactcacc cctaccctgg tgtcactgtt ggaggttatt gaacctgaag   1920

tgttatatgc aggatatgat agctctgttc cagactcaac ttggaggatc atgactacgc   1980

tcaacatgtt aggagggcgg caagtgattg cagcagtgaa atgggcaaag gcaataccag   2040

gtttcaggaa cttacacctg gatgaccaaa tgaccctact gcagtactcc tggatgtttc   2100

ttatggcatt tgctctgggg tggagatcat atagacaatc aagtgcaaac ctgctgtgtt   2160

ttgctcctga tctgattatt aatgagcaga gaatgactct accctgcatg tacgaccaat   2220

gtaaacacat gctgtatgtt tcctctgagt tacacaggct tcaggtatct tatgaagagt   2280

atctctgtat gaaaacctta ctgcttctct cttcagttcc taaggacggt ctgaagagcc   2340

aagagctatt tgatgaaatt agaatgacct acatcaaaga gctaggaaaa gccattgtca   2400

agagggaagg aaactccagc cagaactggc agcggtttta tcaactgaca aaactcttgg   2460

attctatgca tgaagtggtt gaaaatctcc ttaactattg cttccaaaca tttttggata   2520

agaccatgag tattgaattc cccgagatgt tagctgaaat catcaccaat cagataccaa   2580

aatattcaaa tggaaatatc aaaaaacttc tgtttcatca aaagtgactg ccttaataag   2640

aatggttgcc ttaaagaaag tcgaattaat agcttttatt gtataaacta tcagtttgtc   2700

ctgtagaggt tttgttgttt tattttttat tgttttcatc tgttgttttg ttttaaatac   2760

gcactacatg tggtttatag agggccaaga cttggcaaca gaagcagttg agtcgtcatc   2820

acttttcagt gatgggagag tagatggtga aatttattag ttaatatatc ccagaaatta   2880

gaaaccttaa tatgtggacg taatctccac agtcaaagaa ggatggcacc taaaccacca   2940

gtgcccaaag tctgtgtgat gaactttctc ttcatacttt ttttcacagt tggctggatg   3000

aaattttcta gactttctgt tggtgtatcc cccccctgta tagttaggat agcatttttg   3060

atttatgcat ggaaacctga aaaaaagttt acaagtgtat atcagaaaag ggaagttgtg   3120

ccttttatag ctattactgt ctggttttaa caatttcctt tatatttagt gaactacgct   3180

tgctcatttt ttcttacata attttttatt caagttattg tacagctgtt taagatgggc   3240

agctagttcg tagctttccc aaataaactc taaacattaa tcaatcatct gtgtgaaaat   3300

gggttggtgc ttctaacctg atggcactta gctatcagaa gaccacaaaa attgactcaa   3360

atctccagta ttcttgtcaa aaaaaaaaaa aaaaaagctc atattttgta tatatctgct   3420

tcagtggaga attatatagg ttgtgcaaat taacagtcct aactggtata gagcacctag   3480

tccagtgacc tgctgggtaa actgtggatg atggttgcaa aagactaatt taaaaaataa   3540

ctaccaagag gccctgtctg tacctaacgc cctatttttg caatggctat atggcaagaa   3600

agctggtaaa ctatttgtct ttcaggacct tttgaagtag tttgtataac ttcttaaaag   3660

ttgtgattcc agataaccag ctgtaacaca gctgagagac ttttaatcag acaaagtaat   3720

tcctctcact aaactttacc caaaaactaa atctctaata tggcaaaaat ggctagacac   3780

ccattttcac attcccatct gtcaccaatt ggttaatctt tcctgatggt acaggaaagc   3840

tcagctactg atttttgtga tttagaactg tatgtcagac atccatgttt gtaaaactac   3900

acatccctaa tgtgtgccat agagtttaac acaagtcctg tgaatttctt cactgttgaa   3960

aattatttta aacaaaatag aagctgtagt agccctttct gtgtgcacct taccaacttt   4020

ctgtaaactc aaaacttaac atatttacta agccacaaga aatttgattt ctattcaagg   4080

tggccaaatt atttgtgtaa tagaaaactg aaaatctaat attaaaaata tggaacttct   4140

aatatatttt tatatttagt tatagtttca gatatatatc atattggtat tcactaatct   4200

gggaagggaa gggctactgc agctttacat gcaatttatt aaaatgattg taaaatagct   4260

tgtatagtgt aaaataagaa tgatttttag atgagattgt tttatcatga catgttatat   4320

attttttgta ggggtcaaag aaatgctgat ggataaccta tatgatttat agtttgtaca   4380

tgcattcata caggcagcga tggtctcaga aaccaaacag tttgctctag gggaagaggg   4440

agatggagac tggtcctgtg tgcagtgaag gttgctgagg ctctgaccca gtgagattac   4500

agaggaagtt atcctctgcc tcccattctg accacccttc tcattccaac agtgagtctg   4560

tcagcgcagg tttagtttac tcaatctccc cttgcactaa agtatgtaaa gtatgtaaac   4620

aggagacagg aaggtggtgc ttacatcctt aaaggcacca tctaatagcg ggttactttc   4680

acatacagcc ctcccccagc agttgaatga caacagaagc ttcagaagtt tggcaatagt   4740

ttgcatagag gtaccagcaa tatgtaaata gtgcagaatc tcataggttg ccaataatac   4800

actaattcct ttctatccta caacaagagt ttatttccaa ataaaatgag gacatgtttt   4860

tgttttcttt gaatgctttt tgaatgttat ttgttatttt cagtattttg gagaaattat   4920

ttaataaaaa aacaatcatt tgctttttga atgctctcta aaagggaatg taatatttta   4980

agatggtgtg taacccggct ggataaattt ttggtgccta agaaaactgc ttgaatattc   5040

ttatcaatga cagtgttaag tttcaaaaag agcttctaaa acgtagatta tcattccttt   5100

atagaatgtt atgtggttaa aaccagaaag cacatctcac acattaatct gattttcatc   5160

ccaacaatct tggcgctcaa aaaatagaac tcaatgagaa aaagaagatt atgtgcactt   5220

cgttgtcaat aataagtcaa ctgatgctca tcgacaacta taggaggctt ttcattaaat   5280

gggaaaagaa gctgtgccct tttaggatac gtgggggaaa agaaagtcat cttaattatg   5340

tttaattgtg gatttaagtg ctatatggtg gtgctgtttg aaagcagatt tatttcctat   5400

gtatgtgtta tctggccatc ccaacccaaa ctgttgaagt ttgtagtaac ttcagtgaga   5460

gttggttact cacaacaaat cctgaaaagt atttttagtg tttgtaggta ttctgtggga   5520

tactatacaa gcagaactga ggcacttagg acataacact tttggggtat atatatccaa   5580

atgcctaaaa ctatgggagg aaaccttggc caccccaaaa ggaaaactaa catgatttgt   5640

gtctatgaag tgctggataa ttagcatggg atgagctctg ggcatgccat gaaggaaagc   5700

cacgctccct tcagaattca gaggcaggga gcaattccag tttcacctaa gtctcataat   5760

tttagttccc ttttaaaaac cctgaaaact acatcaccat ggaatgaaaa atattgttat   5820

acaatacatt gatctgtcaa acttccagaa ccatggtagc cttcagtgag atttccatct   5880

tggctggtca ctccctgact gtagctgtag gtgaatgtgt ttttgtgtgt gtgtgtctgg   5940

ttttagtgtc agaagggaaa taaaagtgta aggaggacac tttaaaccct ttgggtggag   6000

tttcgtaatt tcccagacta ttttcaagca acctggtcca cccaggatta gtgaccaggt   6060

tttcaggaaa ggatttgctt ctctctagaa aatgtctgaa aggattttat tttctgatga   6120

aaggctgtat gaaaataccc tcctcaaata acttgcttaa ctacatatag attcaagtgt   6180

gtcaatattc tattttgtat attaaatgct atataatggg gacaaatcta tattatactg   6240

tgtatggcat tattaagaag ctttttcatt attttttatc acagtaattt taaaatgtgt   6300

aaaaattaaa accagtgact cctgttt                                       6327


<210>  2279
<211>  777
<212>  PRT
<213>  Homo sapiens

<400>  2279


Met Asp Ser Lys Glu Ser Leu Thr Pro Gly Arg Glu Glu Asn Pro Ser 
1               5                   10                  15      


Ser Val Leu Ala Gln Glu Arg Gly Asp Val Met Asp Phe Tyr Lys Thr 
            20                  25                  30          


Leu Arg Gly Gly Ala Thr Val Lys Val Ser Ala Ser Ser Pro Ser Leu 
        35                  40                  45              


Ala Val Ala Ser Gln Ser Asp Ser Lys Gln Arg Arg Leu Leu Val Asp 
    50                  55                  60                  


Phe Pro Lys Gly Ser Val Ser Asn Ala Gln Gln Pro Asp Leu Ser Lys 
65                  70                  75                  80  


Ala Val Ser Leu Ser Met Gly Leu Tyr Met Gly Glu Thr Glu Thr Lys 
                85                  90                  95      


Val Met Gly Asn Asp Leu Gly Phe Pro Gln Gln Gly Gln Ile Ser Leu 
            100                 105                 110         


Ser Ser Gly Glu Thr Asp Leu Lys Leu Leu Glu Glu Ser Ile Ala Asn 
        115                 120                 125             


Leu Asn Arg Ser Thr Ser Val Pro Glu Asn Pro Lys Ser Ser Ala Ser 
    130                 135                 140                 


Thr Ala Val Ser Ala Ala Pro Thr Glu Lys Glu Phe Pro Lys Thr His 
145                 150                 155                 160 


Ser Asp Val Ser Ser Glu Gln Gln His Leu Lys Gly Gln Thr Gly Thr 
                165                 170                 175     


Asn Gly Gly Asn Val Lys Leu Tyr Thr Thr Asp Gln Ser Thr Phe Asp 
            180                 185                 190         


Ile Leu Gln Asp Leu Glu Phe Ser Ser Gly Ser Pro Gly Lys Glu Thr 
        195                 200                 205             


Asn Glu Ser Pro Trp Arg Ser Asp Leu Leu Ile Asp Glu Asn Cys Leu 
    210                 215                 220                 


Leu Ser Pro Leu Ala Gly Glu Asp Asp Ser Phe Leu Leu Glu Gly Asn 
225                 230                 235                 240 


Ser Asn Glu Asp Cys Lys Pro Leu Ile Leu Pro Asp Thr Lys Pro Lys 
                245                 250                 255     


Ile Lys Asp Asn Gly Asp Leu Val Leu Ser Ser Pro Ser Asn Val Thr 
            260                 265                 270         


Leu Pro Gln Val Lys Thr Glu Lys Glu Asp Phe Ile Glu Leu Cys Thr 
        275                 280                 285             


Pro Gly Val Ile Lys Gln Glu Lys Leu Gly Thr Val Tyr Cys Gln Ala 
    290                 295                 300                 


Ser Phe Pro Gly Ala Asn Ile Ile Gly Asn Lys Met Ser Ala Ile Ser 
305                 310                 315                 320 


Val His Gly Val Ser Thr Ser Gly Gly Gln Met Tyr His Tyr Asp Met 
                325                 330                 335     


Asn Thr Ala Ser Leu Ser Gln Gln Gln Asp Gln Lys Pro Ile Phe Asn 
            340                 345                 350         


Val Ile Pro Pro Ile Pro Val Gly Ser Glu Asn Trp Asn Arg Cys Gln 
        355                 360                 365             


Gly Ser Gly Asp Asp Asn Leu Thr Ser Leu Gly Thr Leu Asn Phe Pro 
    370                 375                 380                 


Gly Arg Thr Val Phe Ser Asn Gly Tyr Ser Ser Pro Ser Met Arg Pro 
385                 390                 395                 400 


Asp Val Ser Ser Pro Pro Ser Ser Ser Ser Thr Ala Thr Thr Gly Pro 
                405                 410                 415     


Pro Pro Lys Leu Cys Leu Val Cys Ser Asp Glu Ala Ser Gly Cys His 
            420                 425                 430         


Tyr Gly Val Leu Thr Cys Gly Ser Cys Lys Val Phe Phe Lys Arg Ala 
        435                 440                 445             


Val Glu Gly Gln His Asn Tyr Leu Cys Ala Gly Arg Asn Asp Cys Ile 
    450                 455                 460                 


Ile Asp Lys Ile Arg Arg Lys Asn Cys Pro Ala Cys Arg Tyr Arg Lys 
465                 470                 475                 480 


Cys Leu Gln Ala Gly Met Asn Leu Glu Ala Arg Lys Thr Lys Lys Lys 
                485                 490                 495     


Ile Lys Gly Ile Gln Gln Ala Thr Thr Gly Val Ser Gln Glu Thr Ser 
            500                 505                 510         


Glu Asn Pro Gly Asn Lys Thr Ile Val Pro Ala Thr Leu Pro Gln Leu 
        515                 520                 525             


Thr Pro Thr Leu Val Ser Leu Leu Glu Val Ile Glu Pro Glu Val Leu 
    530                 535                 540                 


Tyr Ala Gly Tyr Asp Ser Ser Val Pro Asp Ser Thr Trp Arg Ile Met 
545                 550                 555                 560 


Thr Thr Leu Asn Met Leu Gly Gly Arg Gln Val Ile Ala Ala Val Lys 
                565                 570                 575     


Trp Ala Lys Ala Ile Pro Gly Phe Arg Asn Leu His Leu Asp Asp Gln 
            580                 585                 590         


Met Thr Leu Leu Gln Tyr Ser Trp Met Phe Leu Met Ala Phe Ala Leu 
        595                 600                 605             


Gly Trp Arg Ser Tyr Arg Gln Ser Ser Ala Asn Leu Leu Cys Phe Ala 
    610                 615                 620                 


Pro Asp Leu Ile Ile Asn Glu Gln Arg Met Thr Leu Pro Cys Met Tyr 
625                 630                 635                 640 


Asp Gln Cys Lys His Met Leu Tyr Val Ser Ser Glu Leu His Arg Leu 
                645                 650                 655     


Gln Val Ser Tyr Glu Glu Tyr Leu Cys Met Lys Thr Leu Leu Leu Leu 
            660                 665                 670         


Ser Ser Val Pro Lys Asp Gly Leu Lys Ser Gln Glu Leu Phe Asp Glu 
        675                 680                 685             


Ile Arg Met Thr Tyr Ile Lys Glu Leu Gly Lys Ala Ile Val Lys Arg 
    690                 695                 700                 


Glu Gly Asn Ser Ser Gln Asn Trp Gln Arg Phe Tyr Gln Leu Thr Lys 
705                 710                 715                 720 


Leu Leu Asp Ser Met His Glu Val Val Glu Asn Leu Leu Asn Tyr Cys 
                725                 730                 735     


Phe Gln Thr Phe Leu Asp Lys Thr Met Ser Ile Glu Phe Pro Glu Met 
            740                 745                 750         


Leu Ala Glu Ile Ile Thr Asn Gln Ile Pro Lys Tyr Ser Asn Gly Asn 
        755                 760                 765             


Ile Lys Lys Leu Leu Phe His Gln Lys 
    770                 775         

<210>  2280
<211>  461
<212>  DNA
<213>  Homo sapiens

<400>  2280
catcaaggca gccaggagcc aggtgcagac tgggctttga ctctgcctgc agggaggaac     60

tgctgaaggt tccaagcaaa ggaccgccct gacctgcctt aggtttgaac aggatccctc    120

tggctggtgt gtgaagaatt aactgtagat gggcaagtgt ggaaggaagg agagcagtca    180

ggaagctgcc ataaccatct acatgagaga gaatcgtgta acagacacta ctcaatatcg    240

atctcaactg atccagttct ccagtctccc tggaaaacaa tggattgatg cccagggtgc    300

gctgaacact ggaaccatgg tcacttctgc acttcacacg attctgctcc caccagttga    360

gctaccaaca gttcctggtg cttttgcttc ccaaacatgt ttatgccatt tgttgcttat    420

tactgtactt acttaatttg attaaatatt aagtaaaatg a                        461


<210>  2281
<211>  95
<212>  PRT
<213>  Homo sapiens

<400>  2281


Met Gly Lys Cys Gly Arg Lys Glu Ser Ser Gln Glu Ala Ala Ile Thr 
1               5                   10                  15      


Ile Tyr Met Arg Glu Asn Arg Val Thr Asp Thr Thr Gln Tyr Arg Ser 
            20                  25                  30          


Gln Leu Ile Gln Phe Ser Ser Leu Pro Gly Lys Gln Trp Ile Asp Ala 
        35                  40                  45              


Gln Gly Ala Leu Asn Thr Gly Thr Met Val Thr Ser Ala Leu His Thr 
    50                  55                  60                  


Ile Leu Leu Pro Pro Val Glu Leu Pro Thr Val Pro Gly Ala Phe Ala 
65                  70                  75                  80  


Ser Gln Thr Cys Leu Cys His Leu Leu Leu Ile Thr Val Leu Thr 
                85                  90                  95  

<210>  2282
<211>  498
<212>  DNA
<213>  Homo sapiens

<400>  2282
agcccaggaa aggggccagc ttctgtgacg actgctgcag aggcaggtgc agtttgtgtg     60

ccacagatat taactttgat aagcacttaa tgagtgcctt ctctgtgcga gaatggggag    120

gaacaaaatg cagctcctac cctcctcggg ctttagttgt accttaataa caggaatttt    180

catctgcctg gctcctttcc tcaaagaaca aagaagactt tgcttcatta aagtgtctga    240

gaaggaagaa tcgtgtaaca gacactactc aatatcgatc tcaactgatc cagttctcca    300

gtctccctgg aaaacaatgg attgatgccc agggtgcgct gaacactgga accatggtca    360

cttctgcact tcacacgatt ctgctcccac cagttgagct accaacagtt cctggtgctt    420

ttgcttccca aacatgttta tgccatttgt tgcttattac tgtacttact taatttgatt    480

aaatattaag taaaatga                                                  498


<210>  2283
<211>  70
<212>  PRT
<213>  Homo sapiens

<400>  2283


Met Gly Arg Asn Lys Met Gln Leu Leu Pro Ser Ser Gly Phe Ser Cys 
1               5                   10                  15      


Thr Leu Ile Thr Gly Ile Phe Ile Cys Leu Ala Pro Phe Leu Lys Glu 
            20                  25                  30          


Gln Arg Arg Leu Cys Phe Ile Lys Val Ser Glu Lys Glu Glu Ser Cys 
        35                  40                  45              


Asn Arg His Tyr Ser Ile Ser Ile Ser Thr Asp Pro Val Leu Gln Ser 
    50                  55                  60                  


Pro Trp Lys Thr Met Asp 
65                  70  

<210>  2284
<211>  601
<212>  DNA
<213>  Homo sapiens

<400>  2284
aggaaagggg ccagcttctg tgacgactgc tgcagaggca ggtgcagttt gtgtgccaca     60

gatattaact ttgataagca cttaatgagt gccttctctg tgcgagaatg gggaggaaca    120

aaatgcagct cctaccctcc tcgggcttta gttgtacctt aataacagga attttcatct    180

gcctggctcc tttcctcaaa gaacaaagaa gactttgctt cattaaagtg tctgagaagg    240

aaggtttgaa caggatccct ctggctggtg tgtgaagaat taactgtaga tgggcaagtg    300

tggaaggaag gagagcagtc aggaagctgc cataaccatc tacatgagag agaatcgtgt    360

aacagacact actcaatatc gatctcaact gatccagttc tccagtctcc ctggaaaaca    420

atggattgat gcccagggtg cgctgaacac tggaaccatg gtcacttctg cacttcacac    480

gattctgctc ccaccagttg agctaccaac agttcctggt gcttttgctt cccaaacatg    540

tttatgccat ttgttgctta ttactgtact tacttaattt gattaaatat taagtaaaat    600

g                                                                    601


<210>  2285
<211>  95
<212>  PRT
<213>  Homo sapiens

<400>  2285


Met Gly Lys Cys Gly Arg Lys Glu Ser Ser Gln Glu Ala Ala Ile Thr 
1               5                   10                  15      


Ile Tyr Met Arg Glu Asn Arg Val Thr Asp Thr Thr Gln Tyr Arg Ser 
            20                  25                  30          


Gln Leu Ile Gln Phe Ser Ser Leu Pro Gly Lys Gln Trp Ile Asp Ala 
        35                  40                  45              


Gln Gly Ala Leu Asn Thr Gly Thr Met Val Thr Ser Ala Leu His Thr 
    50                  55                  60                  


Ile Leu Leu Pro Pro Val Glu Leu Pro Thr Val Pro Gly Ala Phe Ala 
65                  70                  75                  80  


Ser Gln Thr Cys Leu Cys His Leu Leu Leu Ile Thr Val Leu Thr 
                85                  90                  95  

<210>  2286
<211>  691
<212>  DNA
<213>  Homo sapiens

<400>  2286
gaattttgct cttaactgcc atagaatgag tatgtgcatg catatgcgtg tggaagacag     60

acttttatca ttgatttttt ttaaatagga aaactaaaca acaactaaaa actttctttc    120

tttttttttt tgagacggag tctggctctg tctcccaggc tggagtgcag tggcgcgatc    180

tcggctcact gcaagctccg cctcccagat tcacgccatt ctcctgcctc agcctcccga    240

gcagctggga ctacaggcac ccgccaccac acccggctac ttttttgtat ttttagtaga    300

aatggggttt caccgggtta gccaggatgg tctcgatccc tgacctggtg atccacccgc    360

ctcggcctcc caaggtactg ggattacagg cgtgagccac cgcgcccggt cctaaaaact    420

ttcttagtga gaaagagata aatggaggag gaaagcaaga taaagaggtt tgggatcttt    480

tctgggattt tgctgaacag ggcgtggtga cactggagga gtcagcagat tcggtagcag    540

aagaaaggca agaagaaaga ggacacgcaa tgaagtggat ttctctgtgt acctcccttc    600

ctctccccac tcaccaccca aattacaata atgacattac tccttccttc atttttattt    660

attgagtcaa taaacaaaag tcattaatgg t                                   691


<210>  2287
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  2287


Met Lys Trp Ile Ser Leu Cys Thr Ser Leu Pro Leu Pro Thr His His 
1               5                   10                  15      


Pro Asn Tyr Asn Asn Asp Ile Thr Pro Ser Phe Ile Phe Ile Tyr 
            20                  25                  30      

<210>  2288
<211>  526
<212>  DNA
<213>  Homo sapiens

<400>  2288
aatagcccac tgtgccacag agggcatgcc ttggatgtag agagtgaaga ctttccacaa     60

cttgtgaatg agccctctgt gagtttagcc aaaacattca tgtcaaagaa atggaaatct    120

caaataaaac ccatcgcagg ccaagctcag gagggctggc tagccaacaa atcctgaaca    180

agggggttca agggaaaagg aaaacatgtg tttcataggc atggtgatgg ttggggcaag    240

aaggcatctg cagcctgggt cactggtaac ctgtcgtagt gactgagctg acaccaagcc    300

ttgctctgaa gcagaatctt cctattagta aataccaggc aatgtcacta aaaaggctta    360

caggctgaga agaggaactg aacaaatctt ggagccaaga tgcatctcct tttcaggtgg    420

tacttctcca gggaacgatg tccttatctg tgagaccttg aactgaatgg ggacgaaggg    480

aactgaattg ttcagcggga ctgtaactga cagtggagct cctggt                   526


<210>  2289
<211>  35
<212>  PRT
<213>  Homo sapiens

<400>  2289


Met Glu Ile Ser Asn Lys Thr His Arg Arg Pro Ser Ser Gly Gly Leu 
1               5                   10                  15      


Ala Ser Gln Gln Ile Leu Asn Lys Gly Val Gln Gly Lys Arg Lys Thr 
            20                  25                  30          


Cys Val Ser 
        35  

<210>  2290
<211>  3591
<212>  DNA
<213>  Homo sapiens

<400>  2290
gctagaatgc actgtctttg aagcattgag caggccctca ccagacacca aatctgctgg     60

ttcctggatc ttggacttcc cagcctcata actaggcatc acaaatctcc gagaggaacg    120

catccacttc ctggcctggt agagcggaga gcagaggtgg gcccaggagt ccaagaactt    180

cccctaaggc tgctagtcgc acccatctct tgagcagaga cccaagaggg caggacagga    240

agaatggaag tgagatttgg ccccggtcat gttttccaaa gtgctgacat caggaaaata    300

atagaagtta acgcagatat ggggctgcca ctgaggagag agaagactga aagaagcata    360

tagataaaag tttcagttac ctgaggtcaa ccttggtctg aaattagatt atctgagtag    420

gctgaaccat cggtgaaaag gaggccaagc atctcaaaaa taggacacgt gagagtatgg    480

agccaatgtg acactcaggt gagttagcct tatgatccct aagcatgcag tccttggacc    540

agatgcatca ggatcttctg gtaagtgtgc taaaatatag gctactgaga cccaccctat    600

gtctgtcaaa tcagaatatt ctaaggaagc aggtcccagg gaatatatat tttaaagctc    660

cctaaataca cttcatgggc tgccagattt gggaatcgca ggattaggta gctacctaaa    720

tgaagacact taaatgtgcc aaaagcttct ctttcaccca tccatttatc catctattca    780

cccatccatc aaccaaacat gtgccagtat ctggtatttg cttcatgacc tgctactgct    840

gtggtgggtg caaagataaa tgatcaatgt tctcaaagag tcaatagtct aagagaatgg    900

atgaatgaag tataaataat aaaagatgtg ctatgaagta cgataggggt ccagaaaagt    960

atatacttat tccagattgt ggcagaagac tctggagagg tttcgtttta tataatggca   1020

tgaattcccc ttcagatcca tctctaaatc aagcttcacc tacttctgac tgtttgtgtt   1080

agataccaat cctatggatt tctatagttt tctggaatta ctttttacac actacagtag   1140

agttatgtgg ctgcttccat gttttactta gaagctgaga gcttgataaa agtgaaggct   1200

gcatcttaat catcaccttt tcccccacct cctagctagg gtctggctct gcctaagcag   1260

ctgccattgg tgctcaataa acattgaaga agttgggttg ttgcactggt tatgcaaaga   1320

aagggacaca gtgggtgtaa gcgtggggcg gggagcaaag ctgggaccaa tcatggaaca   1380

cctagaattt gaatcaaatt tgggctttag tttttaggca atgagcctaa gacaattttg   1440

gaagcatcct ttgttcacaa aaaagttaga aatggtgaga actagggcag tctatcacaa   1500

agtgtgggag aggtaatttt atatgtaaac tattataaat cacatttgag ttatgaagtg   1560

agacaattat tccctttgca gtttcatttc attctgtcta attatttcag ggagacattc   1620

tgaattgggt gctagtattt taacacttct ctaacacttt ctctttttaa attttgttta   1680

tttttaattg acaaataata attgtgtata tttatggggt acattgggca tggagggtgg   1740

gttattctgt gatgtcttga cctgtgtgta cattgtaaca cttctctaat actttctaat   1800

ccagccatcc ccaacctttt tggcaccagg aaccagtttt gtggaagacg atttttccac   1860

agatggttgg gggatgattt tgggatggaa ctattccacc tcagatcatc aggcattaga   1920

ttctcataag aagcatgcaa cgtagatccc tcacatatac agttcacaat agggttcatg   1980

gttctatgag aatctaatgc tgccactgat ctaacaggag gcagagctca gctgataatg   2040

ctttttcacc tgctactgac ttcctgctgt gttgcccagt tcctaacagg ccatagactg   2100

gtaccagtcc atagcctggg gcttgaggac ccctgctcta tgatgtctat acaacaataa   2160

aattgcctaa tgatacattt ctcagaatgt atacccatca ttaagtgaca catggctgct   2220

tgtgtatttt tatatatagc taaatgtggc tagattagat gtgatatctc tttggatgca   2280

gggataggtg ggcaagtttc taaaacacga aactaactgt gtcttttctc tgcttaagaa   2340

ccttccatga ctccctgttg ttcataaccg gataaattct aagctgccta actcagaatt   2400

ctagcttaga gatgtctacg cctggctgct cccaacagtt agtctcatgt cctgtctcaa   2460

acatggggct tcagtaagaa tgaaatttcc aaggagaatt ttatattctg catgccttta   2520

aaggctcaag cctggagacc ccccttcttg cctctcttac ccttttcacc agggcaccct   2580

ctattcatcc ttccagagcc ttctctggga agtcctttcc caaagcccac ttcccagcct   2640

aagcttagtg ctatttctgt agatacccag aaacacatca actatatgta cagtttaccc   2700

tagtatgtca aagttatagt tactgcctta ggagggattt tgagcttttc atctttatta   2760

ctcgggcttc tgctactgtg tcaagcaggt agttgacact caacaaatgt ttgtttagcc   2820

taactcagca gaacacatgg agtgtgttca catggagtaa cctgattttg cttagtctgc   2880

aacatttctt gcatgcatcc cctgcttgca gtctcaatta cagtcatcct gtttcagttt   2940

tcttaacttg tcactccctt cctctgataa cttttgccat acctctgtat aacatggcct   3000

actttttgaa aaagattttt ttacattcac ctacatttgt ctcaaatttt tttttaaaag   3060

aaactttgta ttactaccgt cattgaaaac cttcatcact tggcacaaaa gaaagtttaa   3120

aaaatacaac aaaagacatt ctactaaatt ctggctagac aaccttgcct gctctagtag   3180

atgcactgag accattaatg aatctttcat cccaccttgt gtcatattct ttgccacatg   3240

actttgggtc tccctcacta ctaggcaagt tcctgtctcc atctcttgat tctgaattca   3300

gccataatac ttgctctccc caatgttgtt ttagcagatt tgacacatac agaagcgtga   3360

aaaactcttg tgtgactggg atagctcctc tgcaatgaga acatgcctgg gataatgtac   3420

tgaaaagatg tgagaaatac atgaagcaga gtccagtcat cccagccaag aaccagctgt   3480

gaatgtaacc gcatgacttt gaggcaagtc cagaccaaga acaaagaacc actggtctta   3540

aagacagacc tgcagattcc tgagctaaat aaaagtttat tgttgaaagg c            3591


<210>  2291
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  2291


Met Glu Val Arg Phe Gly Pro Gly His Val Phe Gln Ser Ala Asp Ile 
1               5                   10                  15      


Arg Lys Ile Ile Glu Val Asn Ala Asp Met Gly Leu Pro Leu Arg Arg 
            20                  25                  30          


Glu Lys Thr Glu Arg Ser Ile 
        35                  

<210>  2292
<211>  396
<212>  DNA
<213>  Homo sapiens

<400>  2292
taacttgctc ctcaccttcc accgtgattg tgaggcctcc ccagccatgt ggaactatta     60

tctgagtagg ctgaaccatc ggtgaaaagg aggccaagca tctcaaaaat aggacacgtg    120

agagtatgga gccaatgtga cactcagatt tgacacatac agaagcgtga aaaactcttg    180

tgtgactggg atagctcctc tgcaatgaga acatgcctgg gataatgtac tgaaaagatg    240

tgagaaatac atgaagcaga gtccagtcat cccagccaag aaccagctgt gaatgtaacc    300

gcatgacttt gaggcaagtc cagaccaaga acaaagaacc actggtctta aagacagacc    360

tgcagattcc tgagctaaat aaaagtttat tgttga                              396


<210>  2293
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  2293


Met Thr Leu Arg Gln Val Gln Thr Lys Asn Lys Glu Pro Leu Val Leu 
1               5                   10                  15      


Lys Thr Asp Leu Gln Ile Pro Glu Leu Asn Lys Ser Leu Leu 
            20                  25                  30  

<210>  2294
<211>  547
<212>  DNA
<213>  Homo sapiens

<400>  2294
agctgaagaa aattgagatg aaagccagtc cacgcctcag catcctgagg aaatgttctt     60

ccttgatgct ctgagctctc taagaagtta ccacaaaacc aaacccatca gaagtttgca    120

ggacgtcctt gtttagagct gggaaataaa ccacgaaaca gcgcaaagga gagtccaggc    180

ctgccaatgc ttccgcgaac tcctcgcccc gacctcatcc ttctccagct cctacctgca    240

ggcctcagaa atgaatacct tccgcacggt ggctcacgtc tgtaatccca gcactttggg    300

aggccaaggc agatggatca cctgaggtcg ggagttcaag accagcctgg ccaacatggc    360

aaaactccgt gtctactaaa aatacaaaaa tggtggcggg cgcctgtagt cccagctact    420

tgggaggctg aggcaggaga atggctggaa cctgggaggt ggagttgcag tgagccgaga    480

tcgtgccgtt gcactccaac ctgggagaca gagtgaaact ccatctcaaa gaaagaaaga    540

aagaaag                                                              547


<210>  2295
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  2295


Met Leu Pro Arg Thr Pro Arg Pro Asp Leu Ile Leu Leu Gln Leu Leu 
1               5                   10                  15      


Pro Ala Gly Leu Arg Asn Glu Tyr Leu Pro His Gly Gly Ser Arg Leu 
            20                  25                  30          

<210>  2296
<211>  1142
<212>  DNA
<213>  Homo sapiens

<400>  2296
aggaaatgtt cttccttgat gctctgagct ctctaagaag ttaccacaaa accaaaccca     60

tcagaagttt gcaggacgtc cttgtttaga gctgggaaat aaaccacgaa acagcgcaaa    120

ggagagtcca ggcctgccaa tgcttccgcg aactcctcgc cccgacctca tccttctcca    180

gctcctacct gcaggcctca ggcctcctga cctccaggct ccttaccctc ccgctggcct    240

ctgctctaca ctcatctttg tgccctgctt ccaatcatgc caggcctcgg ggtccctgtc    300

tctaacttca ccatgagact caggtgcttc tctacactcc accctctcca acactgtttg    360

gaatctcagg cttggtccca atcctatggg ctaactttga aaagaccgct gttcataagg    420

agagagaaag gaggaagaga tgagaaagga agacagagaa agaaactcta tgatcacggt    480

ttttccaaaa ttcatggtta aattagaact tactatgtgc aaatatagaa gcacgggtcc    540

acagagttcc agagaatgaa tgctgacgac taagcaccag cctccactcc ctgccccata    600

gtgagtatcc ctcctctgtg tgctcatgct gtgaatcccc cccattctac cacttctccc    660

ctcatcactg gcttgctgta ggatcagaag ttccttaaga acaagaacct tctcccagtg    720

tatccccagc acctaataca gaaggtaata aggaggaggc atctgctaaa cgcttgttga    780

aggagtgaaa ttgagagacc aggaagggcc tgcaggcatt gtggtgagcc tgcctgttgt    840

ccacgtggct gcagcaagca aacatgggtt ttccttggaa ggactgtggg ccatcaaccc    900

attaattgcc gagttgcttc tatcagggca aggctgtgga atcctgttat cctagacaat    960

gaggtacagg gtgcaagcag atctgtgtgc tgctgtcttc cggtaaacgg accaagttct   1020

cacttcccat cctcctcccc agtctcaccc acccgtgctc ccaagagagc aattcatcat   1080

gtcagtgtct ggtgttttct tgaaggcctg tgctaaataa agtggattgt ttataaagtg   1140

gg                                                                  1142


<210>  2297
<211>  58
<212>  PRT
<213>  Homo sapiens

<400>  2297


Met Leu Pro Arg Thr Pro Arg Pro Asp Leu Ile Leu Leu Gln Leu Leu 
1               5                   10                  15      


Pro Ala Gly Leu Arg Pro Pro Asp Leu Gln Ala Pro Tyr Pro Pro Ala 
            20                  25                  30          


Gly Leu Cys Ser Thr Leu Ile Phe Val Pro Cys Phe Gln Ser Cys Gln 
        35                  40                  45              


Ala Ser Gly Ser Leu Ser Leu Thr Ser Pro 
    50                  55              

<210>  2298
<211>  1437
<212>  DNA
<213>  Homo sapiens

<400>  2298
caggaggtct cagcatgaaa cagcagcagt ggtgtgggat gactgccaaa atgggcaccg     60

tgttgtcagg ggtcttcacc atcatggccg tagacatgta tctcatcttt gaacagaagc    120

acctagggaa tggcagttgc actgagatca caccaaagta caggggtgca agtaacatca    180

taaataactt catcatctgc tggagtttta aaatcgtcct cttcctgtct ttcatcacca    240

tcctcatcag ctgcttcctc ctgtactcag tgtatgccca gatcttcagg ggcctggtca    300

tctacattgt ctggattttt ttctatgaaa ctgcaaacgt cgtaatacaa atcctcacca    360

acaatgactt tgacattaaa gaggtcagaa tcatgcgctg gtttggcttg gtgtctcgta    420

cagtcatgca ctgtttctgg atgttctttg tcatcaacta tgcccacata acctacaaaa    480

accggagcca gggcaatata atttcctaca agagacgaat ttctacagcg gagattctcc    540

acagcagaaa taaaagatta tcaatttcga gtgggttcag tggctcacac ctggaatccc    600

agtactttga gaggcagagg aggtgctctg gtaaaacaag tataaaatga atgtcaggat    660

gttctccctc atggtgggca tcttctctgt ccttaatacc acccagttct tcatctttga    720

cctgaaccag aagacacaca tttgctatga ggccaagttc agcatctacg tggactcaaa    780

gtcggagcta gtcacttgga ccctgttcca cagggctaat atcagcactg gcctctccct    840

caccaccatc atcatcggct gcttcctctt ttattgtatc cacaagaata tctacatggg    900

gctgctgatc tatgccatgt ggatcatcac ttacgagctc atcaacttct ccatagtcct    960

gctcctcaac gggatcatca aagatcactt caagacgctg agttatttgc actggatctt   1020

ccaaatctca cacatgctcc tgcacttttt ctgtctgccc ttcatcgtca agcatgcata   1080

caacctttac aaggaatccc agactgtggg caggaaacgc cgccacaggc tctgctccac   1140

cattgcagtg aactcatgac tacctgtccg tctgggaatg ttgtaccgga agttaaactg   1200

aaccatgcca gatgccagga aaggtgggag ggaatggtgt tcctcaacaa tggaaccctc   1260

cctaccctgc ctgtcttctg ttgatgctgc ttggtttgtc agggcttttg agttttacgc   1320

actgaggaat gattctcggg agagggcagg ttgtgcggat caattatttt acagatgtgt   1380

tgtgtgactt gttttagcag ttaatgatat gtggccttgt gcttacttaa ccatctc      1437


<210>  2299
<211>  211
<212>  PRT
<213>  Homo sapiens

<400>  2299


Met Lys Gln Gln Gln Trp Cys Gly Met Thr Ala Lys Met Gly Thr Val 
1               5                   10                  15      


Leu Ser Gly Val Phe Thr Ile Met Ala Val Asp Met Tyr Leu Ile Phe 
            20                  25                  30          


Glu Gln Lys His Leu Gly Asn Gly Ser Cys Thr Glu Ile Thr Pro Lys 
        35                  40                  45              


Tyr Arg Gly Ala Ser Asn Ile Ile Asn Asn Phe Ile Ile Cys Trp Ser 
    50                  55                  60                  


Phe Lys Ile Val Leu Phe Leu Ser Phe Ile Thr Ile Leu Ile Ser Cys 
65                  70                  75                  80  


Phe Leu Leu Tyr Ser Val Tyr Ala Gln Ile Phe Arg Gly Leu Val Ile 
                85                  90                  95      


Tyr Ile Val Trp Ile Phe Phe Tyr Glu Thr Ala Asn Val Val Ile Gln 
            100                 105                 110         


Ile Leu Thr Asn Asn Asp Phe Asp Ile Lys Glu Val Arg Ile Met Arg 
        115                 120                 125             


Trp Phe Gly Leu Val Ser Arg Thr Val Met His Cys Phe Trp Met Phe 
    130                 135                 140                 


Phe Val Ile Asn Tyr Ala His Ile Thr Tyr Lys Asn Arg Ser Gln Gly 
145                 150                 155                 160 


Asn Ile Ile Ser Tyr Lys Arg Arg Ile Ser Thr Ala Glu Ile Leu His 
                165                 170                 175     


Ser Arg Asn Lys Arg Leu Ser Ile Ser Ser Gly Phe Ser Gly Ser His 
            180                 185                 190         


Leu Glu Ser Gln Tyr Phe Glu Arg Gln Arg Arg Cys Ser Gly Lys Thr 
        195                 200                 205             


Ser Ile Lys 
    210     

<210>  2300
<211>  1522
<212>  DNA
<213>  Homo sapiens

<400>  2300
caggaggtct cagcatgaaa cagcagcagt ggtgtgggat gactgccaaa atgggcaccg     60

tgttgtcagg ggtcttcacc atcatggccg tagacatgta tctcatcttt gaacagaagc    120

acctagggaa tggcagttgc actgagatca caccaaagta caggggtgca agtaacatca    180

taaataactt catcatctgc tggagtttta aaatcgtcct cttcctgtct ttcatcacca    240

tcctcatcag ctgcttcctc ctgtactcag tgtatgccca gatcttcagg ggcctggtca    300

tctacattgt ctggattttt ttctatgaaa ctgcaaacgt cgtaatacaa atcctcacca    360

acaatgactt tgacattaaa gaggtcagaa tcatgcgctg gtttggcttg gtgtctcgta    420

cagtcatgca ctgtttctgg atgttctttg tcatcaacta tgcccacata acctacaaaa    480

accggagcca gggcaatata atttcctaca agagacgaat ttctacagcg gagattctcc    540

acagcagaaa taaaagatta tcaatttcga gtgggttcag tggctcacac ctggaatccc    600

agtactttga gaggcagagc ttccacacta gcatatttac ctgtctgtct ccagtgccaa    660

gctcagcccc cagcacctgt agatacacaa tagatgtctg ctgagaggtg ctctggtaaa    720

acaagtataa aatgaatgtc aggatgttct ccctcatggt gggcatcttc tctgtcctta    780

ataccaccca gttcttcatc tttgacctga accagaagac acacatttgc tatgaggcca    840

agttcagcat ctacgtggac tcaaagtcgg agctagtcac ttggaccctg ttccacaggg    900

ctaatatcag cactggcctc tccctcacca ccatcatcat cggctgcttc ctcttttatt    960

gtatccacaa gaatatctac atggggctgc tgatctatgc catgtggatc atcacttacg   1020

agctcatcaa cttctccata gtcctgctcc tcaacgggat catcaaagat cacttcaaga   1080

cgctgagtta tttgcactgg atcttccaaa tctcacacat gctcctgcac tttttctgtc   1140

tgcccttcat cgtcaagcat gcatacaacc tttacaagga atcccagact gtgggcagga   1200

aacgccgcca caggctctgc tccaccattg cagtgaactc atgactacct gtccgtctgg   1260

gaatgttgta ccggaagtta aactgaacca tgccagatgc caggaaaggt gggagggaat   1320

ggtgttcctc aacaatggaa ccctccctac cctgcctgtc ttctgttgat gctgcttggt   1380

ttgtcagggc ttttgagttt tacgcactga ggaatgattc tcgggagagg gcaggttgtg   1440

cggatcaatt attttacaga tgtgttgtgt gacttgtttt agcagttaat gatatgtggc   1500

cttgtgctta cttaaccatc tc                                            1522


<210>  2301
<211>  229
<212>  PRT
<213>  Homo sapiens

<400>  2301


Met Lys Gln Gln Gln Trp Cys Gly Met Thr Ala Lys Met Gly Thr Val 
1               5                   10                  15      


Leu Ser Gly Val Phe Thr Ile Met Ala Val Asp Met Tyr Leu Ile Phe 
            20                  25                  30          


Glu Gln Lys His Leu Gly Asn Gly Ser Cys Thr Glu Ile Thr Pro Lys 
        35                  40                  45              


Tyr Arg Gly Ala Ser Asn Ile Ile Asn Asn Phe Ile Ile Cys Trp Ser 
    50                  55                  60                  


Phe Lys Ile Val Leu Phe Leu Ser Phe Ile Thr Ile Leu Ile Ser Cys 
65                  70                  75                  80  


Phe Leu Leu Tyr Ser Val Tyr Ala Gln Ile Phe Arg Gly Leu Val Ile 
                85                  90                  95      


Tyr Ile Val Trp Ile Phe Phe Tyr Glu Thr Ala Asn Val Val Ile Gln 
            100                 105                 110         


Ile Leu Thr Asn Asn Asp Phe Asp Ile Lys Glu Val Arg Ile Met Arg 
        115                 120                 125             


Trp Phe Gly Leu Val Ser Arg Thr Val Met His Cys Phe Trp Met Phe 
    130                 135                 140                 


Phe Val Ile Asn Tyr Ala His Ile Thr Tyr Lys Asn Arg Ser Gln Gly 
145                 150                 155                 160 


Asn Ile Ile Ser Tyr Lys Arg Arg Ile Ser Thr Ala Glu Ile Leu His 
                165                 170                 175     


Ser Arg Asn Lys Arg Leu Ser Ile Ser Ser Gly Phe Ser Gly Ser His 
            180                 185                 190         


Leu Glu Ser Gln Tyr Phe Glu Arg Gln Ser Phe His Thr Ser Ile Phe 
        195                 200                 205             


Thr Cys Leu Ser Pro Val Pro Ser Ser Ala Pro Ser Thr Cys Arg Tyr 
    210                 215                 220                 


Thr Ile Asp Val Cys 
225                 

<210>  2302
<211>  1397
<212>  DNA
<213>  Homo sapiens

<400>  2302
aaagctcgct gttcgcttcg ctgcctgaca gctgccctgc cgccaccagg cagtcccagc     60

ttccccaaac cagtcttctg gcctctgtgg cgccccaggc ccgcgggatt cagggattag    120

gatctggaag ggtttggtcc aatcccctat ccctctcagc gtcctgggct cacctccccg    180

gcagcttagc gctcctcttc caaaactgct tgctgttctc agcggccatt gctctggccg    240

ggggaagtcc ttgtaggcgg gccaagggtt tgcccggcga gatgccccca gaccccgcaa    300

tctgagggcc aacccaggcc gcttccccgc cgccggtcac ccgctcccag ctcctgggga    360

cgccatcttg gatgtgggca cccctccacc cagcaccgct gccattggtg agctgcgcaa    420

gccgtggacg ggccgaccaa ttgggagccg gaatcctgca ggccgctgaa gccgaccggt    480

aacgtcaggg gctgggcaca caggtggacg gggaaggcgg agcttggacg agccgagagg    540

cggggctcaa agttcctacc cgcgagaggg aagaagcagg aggtgctctg gtaaaacaag    600

tataaaatga atgtcaggat gttctccctc atggtgggca tcttctctgt ccttaatacc    660

acccagttct tcatctttga cctgaaccag aagacacaca tttgctatga ggccaagttc    720

agcatctacg tggactcaaa gtcggagcta gtcacttgga ccctgttcca cagggctaat    780

atcagcactg gcctctccct caccaccatc atcatcggct gcttcctctt ttattgtatc    840

cacaagaata tctacatggg gctgctgatc tatgccatgt ggatcatcac ttacgagctc    900

atcaacttct ccatagtcct gctcctcaac gggatcatca aagatcactt caagacgctg    960

agttatttgc actggatctt ccaaatctca cacatgctcc tgcacttttt ctgtctgccc   1020

ttcatcgtca agcatgcata caacctttac aaggaatccc agactgtggg caggaaacgc   1080

cgccacaggc tctgctccac cattgcagtg aactcatgac tacctgtccg tctgggaatg   1140

ttgtaccgga agttaaactg aaccatgcca gatgccagga aaggtgggag ggaatggtgt   1200

tcctcaacaa tggaaccctc cctaccctgc ctgtcttctg ttgatgctgc ttggtttgtc   1260

agggcttttg agttttacgc actgaggaat gattctcggg agagggcagg ttgtgcggat   1320

caattatttt acagatgtgt tgtgtgactt gttttagcag ttaatgatat gtggccttgt   1380

gcttacttaa ccatctc                                                  1397


<210>  2303
<211>  170
<212>  PRT
<213>  Homo sapiens

<400>  2303


Met Asn Val Arg Met Phe Ser Leu Met Val Gly Ile Phe Ser Val Leu 
1               5                   10                  15      


Asn Thr Thr Gln Phe Phe Ile Phe Asp Leu Asn Gln Lys Thr His Ile 
            20                  25                  30          


Cys Tyr Glu Ala Lys Phe Ser Ile Tyr Val Asp Ser Lys Ser Glu Leu 
        35                  40                  45              


Val Thr Trp Thr Leu Phe His Arg Ala Asn Ile Ser Thr Gly Leu Ser 
    50                  55                  60                  


Leu Thr Thr Ile Ile Ile Gly Cys Phe Leu Phe Tyr Cys Ile His Lys 
65                  70                  75                  80  


Asn Ile Tyr Met Gly Leu Leu Ile Tyr Ala Met Trp Ile Ile Thr Tyr 
                85                  90                  95      


Glu Leu Ile Asn Phe Ser Ile Val Leu Leu Leu Asn Gly Ile Ile Lys 
            100                 105                 110         


Asp His Phe Lys Thr Leu Ser Tyr Leu His Trp Ile Phe Gln Ile Ser 
        115                 120                 125             


His Met Leu Leu His Phe Phe Cys Leu Pro Phe Ile Val Lys His Ala 
    130                 135                 140                 


Tyr Asn Leu Tyr Lys Glu Ser Gln Thr Val Gly Arg Lys Arg Arg His 
145                 150                 155                 160 


Arg Leu Cys Ser Thr Ile Ala Val Asn Ser 
                165                 170 

<210>  2304
<211>  902
<212>  DNA
<213>  Homo sapiens

<400>  2304
gctctctgat ttatatctag tgacttgggg gatttgtcta aggctacctc tgccatcttg     60

tcacgtgtct gtatgatttt cttcctgcag gaggtgctct ggtaaaacaa gtataaaatg    120

aatgtcagga tgttctccct catggtgggc atcttctctg tccttaatac cacccagttc    180

ttcatctttg acctgaacca gaagacacac atttgctatg aggccaagtt cagcatctac    240

gtggactcaa agtcggagct agtcacttgg accctgttcc acagggctaa tatcagcact    300

ggcctctccc tcaccaccat catcatcggc tgcttcctct tttattgtat ccacaagaat    360

atctacatgg ggctgctgat ctatgccatg tggatcatca cttacgagct catcaacttc    420

tccatagtcc tgctcctcaa cgggatcatc aaagatcact tcaagacgct gagttatttg    480

cactggatct tccaaatctc acacatgctc ctgcactttt tctgtctgcc cttcatcgtc    540

aagcatgcat acaaccttta caaggaatcc cagactgtgg gcaggaaacg ccgccacagg    600

ctctgctcca ccattgcagt gaactcatga ctacctgtcc gtctgggaat gttgtaccgg    660

aagttaaact gaaccatgcc agatgccagg aaaggtggga gggaatggtg ttcctcaaca    720

atggaaccct ccctaccctg cctgtcttct gttgatgctg cttggtttgt cagggctttt    780

gagttttacg cactgaggaa tgattctcgg gagagggcag gttgtgcgga tcaattattt    840

tacagatgtg ttgtgtgact tgttttagca gttaatgata tgtggccttg tgcttactta    900

ac                                                                   902


<210>  2305
<211>  170
<212>  PRT
<213>  Homo sapiens

<400>  2305


Met Asn Val Arg Met Phe Ser Leu Met Val Gly Ile Phe Ser Val Leu 
1               5                   10                  15      


Asn Thr Thr Gln Phe Phe Ile Phe Asp Leu Asn Gln Lys Thr His Ile 
            20                  25                  30          


Cys Tyr Glu Ala Lys Phe Ser Ile Tyr Val Asp Ser Lys Ser Glu Leu 
        35                  40                  45              


Val Thr Trp Thr Leu Phe His Arg Ala Asn Ile Ser Thr Gly Leu Ser 
    50                  55                  60                  


Leu Thr Thr Ile Ile Ile Gly Cys Phe Leu Phe Tyr Cys Ile His Lys 
65                  70                  75                  80  


Asn Ile Tyr Met Gly Leu Leu Ile Tyr Ala Met Trp Ile Ile Thr Tyr 
                85                  90                  95      


Glu Leu Ile Asn Phe Ser Ile Val Leu Leu Leu Asn Gly Ile Ile Lys 
            100                 105                 110         


Asp His Phe Lys Thr Leu Ser Tyr Leu His Trp Ile Phe Gln Ile Ser 
        115                 120                 125             


His Met Leu Leu His Phe Phe Cys Leu Pro Phe Ile Val Lys His Ala 
    130                 135                 140                 


Tyr Asn Leu Tyr Lys Glu Ser Gln Thr Val Gly Arg Lys Arg Arg His 
145                 150                 155                 160 


Arg Leu Cys Ser Thr Ile Ala Val Asn Ser 
                165                 170 

<210>  2306
<211>  1449
<212>  DNA
<213>  Homo sapiens

<400>  2306
gccgtcccca aagctcgctg ttcgcttcgc tgcctgacag ctgccctgcc gccaccaggc     60

agtcccagct tccccaaacc agtcttctgg cctctgtggc gccccaggcc cgcgggattc    120

agggattagg atctggaagg gtttggtcca atcccctatc cctctcagcg tcctgggctc    180

acctccccgg cagcttagcg ctcctcttcc aaaactgctt gctgttctca gcggccattg    240

ctctggccgg gggaagtcct tgtaggcggg ccaagggttt gcccggcgag atgcccccag    300

accccgcaat ctgagggcca acccaggccg cttccccgcc gccggtcacc cgctcccagc    360

tcctggggac gccatcttgg atgtgggcac ccctccaccc agcaccgctg ccattggtga    420

gctgcgcaag ccgtggacgg gccgaccaat tgggagccgg aatcctgcag gccgctgaag    480

ccgaccggta acgtcagggg ctgggcacac aggtggacgg ggaaggcgga gcttggacga    540

gccgagaggc ggggctcaaa gttcctaccc gcgagaggga agaagcaggt aaggaggtct    600

cagcatgaaa cagcagcagt ggtgtgggat gactgccaaa atgggcaccg tgttgtcagg    660

ggtcttcacc atcatggccg tagacatgta tctcatcttt gaacagaagc acctagggaa    720

tggcagttgc actgagatca caccaaagta caggggtgca agtaacatca taaataactt    780

catcatctgc tggagtttta aaatcgtcct cttcctgtct ttcatcacca tcctcatcag    840

ctgcttcctc ctgtactcag tgtatgccca gatcttcagg ggcctggtca tctacattgt    900

ctggattttt ttctatgaaa ctgcaaacgt cgtaatacaa atcctcacca acaatgactt    960

tgacattaaa gaggtcagaa tcatgcgctg gtttggcttg gtgtctcgta cagtcatgca   1020

ctgtttctgg atgttctttg tcatcaacta tgcccacata acctacaaaa accggagcca   1080

gggcaatata atttcctaca agagacgaat ttctacagcg gagattctcc acagcagaaa   1140

taaaagatta tcaatttcga gtgggttcag tggctcacac ctggaatccc agtactttga   1200

gaggcagagg taggtggatc gcctgaggtc aggagttcaa gaccagcctg gccttggcag   1260

ccatggcaaa accccgtctc tactaaaaaa aatagaaaat tagccaggcg tggcggcaca   1320

cacctgtaat cccagccact tgagaggctg agactggaga atcacttgac ctgggaggtg   1380

gaggttgcag tgagccgaga ttgcgccagt gcacttcagc ctgagtgaca gagtaagact   1440

ctgtccccc                                                           1449


<210>  2307
<211>  202
<212>  PRT
<213>  Homo sapiens

<400>  2307


Met Lys Gln Gln Gln Trp Cys Gly Met Thr Ala Lys Met Gly Thr Val 
1               5                   10                  15      


Leu Ser Gly Val Phe Thr Ile Met Ala Val Asp Met Tyr Leu Ile Phe 
            20                  25                  30          


Glu Gln Lys His Leu Gly Asn Gly Ser Cys Thr Glu Ile Thr Pro Lys 
        35                  40                  45              


Tyr Arg Gly Ala Ser Asn Ile Ile Asn Asn Phe Ile Ile Cys Trp Ser 
    50                  55                  60                  


Phe Lys Ile Val Leu Phe Leu Ser Phe Ile Thr Ile Leu Ile Ser Cys 
65                  70                  75                  80  


Phe Leu Leu Tyr Ser Val Tyr Ala Gln Ile Phe Arg Gly Leu Val Ile 
                85                  90                  95      


Tyr Ile Val Trp Ile Phe Phe Tyr Glu Thr Ala Asn Val Val Ile Gln 
            100                 105                 110         


Ile Leu Thr Asn Asn Asp Phe Asp Ile Lys Glu Val Arg Ile Met Arg 
        115                 120                 125             


Trp Phe Gly Leu Val Ser Arg Thr Val Met His Cys Phe Trp Met Phe 
    130                 135                 140                 


Phe Val Ile Asn Tyr Ala His Ile Thr Tyr Lys Asn Arg Ser Gln Gly 
145                 150                 155                 160 


Asn Ile Ile Ser Tyr Lys Arg Arg Ile Ser Thr Ala Glu Ile Leu His 
                165                 170                 175     


Ser Arg Asn Lys Arg Leu Ser Ile Ser Ser Gly Phe Ser Gly Ser His 
            180                 185                 190         


Leu Glu Ser Gln Tyr Phe Glu Arg Gln Arg 
        195                 200         

<210>  2308
<211>  3543
<212>  DNA
<213>  Homo sapiens

<400>  2308
tgctgggtgg aggggtgccc acatccaaga tggcgtcccc aggagctggg agcgggtgac     60

cggcggcggg gaagcggcct gggttggccc tcagattgcg gggtctgggg gcatctcgcc    120

gggcaaaccc ttggcccgcc tacaaggact tcccccggcc agagcaatgg ccgctgagaa    180

cagcaagcag ttttggaaga ggagcgctaa gctgccgggg agcattcagc ctgtatatgg    240

agcacagcat cctcctcttg acccacggct caccaaaaat ttcattaaag aacgatcaaa    300

agtcaacaca gttcctctga agaataagaa ggcctccagt tttcatgagt ttgcacggaa    360

taccagtgat gcttgggaca ttggcgatga tgaggaagag gacttttcct caccttcttt    420

ccaaactctg aactcaaaag ttgctttggc aactgcagcc caagttctag aaaaccacag    480

caagctgaga gtaaaaccag aacggtccca gtcaacgaca tcggacgtcc ctgccaacta    540

caaggtcata aagtccagca gtgatgccca gctgtccaga aactctagtg atacatgcct    600

gaggaaccca ctccacaaac agcaatcact ccctctccgg cccatcatcc ccctcgttgc    660

ccggatctcg gatcagaacg cttctggggc ccccccaatg actgtccggg agaaaacccg    720

cctagaaaaa ttccgtcaac ttctctccag ccagaacact gacttagatg aactgaggaa    780

gtgtagctgg ccaggggttc ccagggaggt tcgacctata acctggagac tcctgtcggt    840

gagttctacc cactgtgtag agaaatgtga gcctcacaca gcccttcttg cctgatgagg    900

gctatctccc agcaaacact gagaggagga agttgaccct gcagcggaag cgggaggaat    960

attttggctt cattgaacag tattatgact ctcgaaacga ggaacatcac caggatacct   1020

acagacagat tcacattgac attccaagga cgaatcctct cattccgttg ttccagcaac   1080

cacttgtaca ggagatcttt gaaagaattc tatttatttg ggccatccgc caccctgcca   1140

gtgggtatgt ccagggaatt aatgacctgg tcactccatt ctttgtcgtc ttcctctcag   1200

aatatgtgga agaggatgtg gagaactttg acgtgaccaa cttgtctcaa gacatgctgc   1260

gaagcattga ggctgacagc ttttggtgca tgagcaagct gctggatgga atccaggata   1320

actacacctt tgcacaacca ggaatccaga agaaggtgaa ggcactggaa gagcttgtca   1380

gccggattga tgagcaggta cataatcact tcaggaggta cgaggtagaa tacctgcagt   1440

ttgccttccg ctggatgaac aacctgctta tgcgggagct tcctcttcgc tgcaccatcc   1500

gcctgtggga cacatatcag tctgaaccag aagggttctc ccactttcat ctctacgtgt   1560

gtgcagcctt cttgatcaag tggaggaaag agatcttgga tgaggaggat tttcagggtc   1620

tcctcatgct gctacagaac ctacctacaa tacactgggg caacgaagaa attgggctgc   1680

ttctcgccga ggcatacaga ctcaagtaca tgtttgccga tgccccaaat cactaccgcc   1740

gataggtgct gtctcctccg gggacccaga ctgccttcat ctctgatggc agtctgatca   1800

ctgtggccac tgtgcgagcc gtggaccccg gccaggaacc actcctgttg tacaaagctc   1860

acacccaccg cccaggtctt aactttctgg catccaccac tccatgtctc tggatgtgtc   1920

acttggacca ctgtcagtat tccatgccgc gtggatgggc ccagttctgg gagaggacag   1980

aaaaggtggt acagggttgt ctgccccttt aaaagaaact ggacaaagaa ggggaaggct   2040

cagggtctca cctcacattg tccctacaag gacaggcccc aactgataac cgttgctttt   2100

ttttttttgt gaacatagtt tgatttgatc acaggtcaaa aacgccttat attttcgaaa   2160

gactcctggc ccctcttccc tcttcctggt ttcctagccg ttccccttct gccccagtct   2220

gagccagtga ggggtagctt tttaaaacca ttattctaga tggaggaggc actgatgctt   2280

gtaactctgg aaagaggcct acacccaagg gctaggaatt ttatttttcc ttttctcacc   2340

aggtgtctgc atgtgtgtgt gggtgtgaat gtgtatacat gcccatcagc atttagtcac   2400

atgtctgaat ttctgtgtcc agacgagccc catcaaacta gttgggaagg gccccagtga   2460

ccaagtgtat aagcatccct tgaagaggga ttggggcagg ggaggcagaa ggggctctcc   2520

agaccccttt tccatgatga cccactccaa gatattatgt gtaaattgtg ttattatgta   2580

tatgggtaaa gatgtacaaa tatatgtcct ctttgtagca gatatgattt tatatttata   2640

atgtgcatca acatgtgaaa gcaatctagg tcactagcac agaggaagtt gccaggaagg   2700

tggcttcagc acctccaggt tggttctggg tgtcctgctg tgaggggtag aacgggaggc   2760

tgctgaagtg agtagctgag cagctggagc catcccaagc atcagtgtct cagagtcctc   2820

ctcgcccctt tcttcacccc gccccccaac ccccagactt tcctggagca tctgcccttt   2880

gctcctagca gcctccccag gaagggactg cagaggcggg caagccctct ctatgtgttt   2940

ttatccccac cttccccgga atctggggag ggcttttgtt tttacgtttt caagttcagc   3000

attgtattcg gacagaagct gtgactgaag actcagtgcc aaggaaaggg gcttcttgtg   3060

tgtccctcgg gtttggggct cttctcagag agcagcactc catatccctt actgtcacct   3120

tcactcccca cacagctcat gagatgtgtg acccctgttt gagttttggt atttggtagt   3180

ggagggtggg gggatggggg ccagcagctg tcatcctcct gggaagccga gcagtgtccc   3240

tggtgggtaa caccctcaag tctctttgcc agtgaggccc caccacatcg gtgtgagtta   3300

ggtttctcat ctggagctgt ttctcaggca ttcttcccaa ccctcttcct tttccccttc   3360

ggtgtgcctc agtggtctcc ttcatagagt gagagggctt gagaccctcc ctcaaccgga   3420

ctaattaaag aaagacactt gtgttcccaa gtggtggttt tattttttta gtttttatgt   3480

ttgtatggga aattgtggat aaagtgaaaa gaattgtaaa taaatggtgt atttcctcct   3540

cca                                                                 3543


<210>  2309
<211>  242
<212>  PRT
<213>  Homo sapiens

<400>  2309


Met Ala Ala Glu Asn Ser Lys Gln Phe Trp Lys Arg Ser Ala Lys Leu 
1               5                   10                  15      


Pro Gly Ser Ile Gln Pro Val Tyr Gly Ala Gln His Pro Pro Leu Asp 
            20                  25                  30          


Pro Arg Leu Thr Lys Asn Phe Ile Lys Glu Arg Ser Lys Val Asn Thr 
        35                  40                  45              


Val Pro Leu Lys Asn Lys Lys Ala Ser Ser Phe His Glu Phe Ala Arg 
    50                  55                  60                  


Asn Thr Ser Asp Ala Trp Asp Ile Gly Asp Asp Glu Glu Glu Asp Phe 
65                  70                  75                  80  


Ser Ser Pro Ser Phe Gln Thr Leu Asn Ser Lys Val Ala Leu Ala Thr 
                85                  90                  95      


Ala Ala Gln Val Leu Glu Asn His Ser Lys Leu Arg Val Lys Pro Glu 
            100                 105                 110         


Arg Ser Gln Ser Thr Thr Ser Asp Val Pro Ala Asn Tyr Lys Val Ile 
        115                 120                 125             


Lys Ser Ser Ser Asp Ala Gln Leu Ser Arg Asn Ser Ser Asp Thr Cys 
    130                 135                 140                 


Leu Arg Asn Pro Leu His Lys Gln Gln Ser Leu Pro Leu Arg Pro Ile 
145                 150                 155                 160 


Ile Pro Leu Val Ala Arg Ile Ser Asp Gln Asn Ala Ser Gly Ala Pro 
                165                 170                 175     


Pro Met Thr Val Arg Glu Lys Thr Arg Leu Glu Lys Phe Arg Gln Leu 
            180                 185                 190         


Leu Ser Ser Gln Asn Thr Asp Leu Asp Glu Leu Arg Lys Cys Ser Trp 
        195                 200                 205             


Pro Gly Val Pro Arg Glu Val Arg Pro Ile Thr Trp Arg Leu Leu Ser 
    210                 215                 220                 


Val Ser Ser Thr His Cys Val Glu Lys Cys Glu Pro His Thr Ala Leu 
225                 230                 235                 240 


Leu Ala 
        

<210>  2310
<211>  3482
<212>  DNA
<213>  Homo sapiens

<400>  2310
tgctgggtgg aggggtgccc acatccaaga tggcgtcccc aggagctggg agcgggtgac     60

cggcggcggg gaagcggcct gggttggccc tcagattgcg gggtctgggg gcatctcgcc    120

gggcaaaccc ttggcccgcc tacaaggact tcccccggcc agagcaatgg ccgctgagaa    180

cagcaagcag ttttggaaga ggagcgctaa gctgccgggg agcattcagc ctgtatatgg    240

agcacagcat cctcctcttg acccacggct caccaaaaat ttcattaaag aacgatcaaa    300

agtcaacaca gttcctctga agaataagaa ggcctccagt tttcatgagt ttgcacggaa    360

taccagtgat gcttgggaca ttggcgatga tgaggaagag gacttttcct caccttcttt    420

ccaaactctg aactcaaaag ttgctttggc aactgcagcc caagttctag aaaaccacag    480

caagctgaga gtaaaaccag aacggtccca gtcaacgaca tcggacgtcc ctgccaacta    540

caaggtcata aagtccagca gtgatgccca gctgtccaga aactctagtg atacatgcct    600

gaggaaccca ctccacaaac agcaatcact ccctctccgg cccatcatcc ccctcgttgc    660

ccggatctcg gatcagaacg cttctggggc ccccccaatg actgtccggg agaaaacccg    720

cctagaaaaa ttccgtcaac ttctctccag ccagaacact gacttagatg aactgaggaa    780

gtgtagctgg ccaggggttc ccagggaggt tcgacctata acctggagac tcctgtcggg    840

ctatctccca gcaaacactg agaggaggaa gttgaccctg cagcggaagc gggaggaata    900

ttttggcttc attgaacagt attatgactc tcgaaacgag gaacatcacc aggataccta    960

cagacagatt cacattgaca ttccaaggac gaatcctctc attccgttgt tccagcaacc   1020

acttgtacag gagatctttg aaagaattct atttatttgg gccatccgcc accctgccag   1080

tgggtatgtc cagggaatta atgacctggt cactccattc tttgtcgtct tcctctcaga   1140

atatgtggaa gaggatgtgg agaactttga cgtgaccaac ttgtctcaag acatgctgcg   1200

aagcattgag gctgacagct tttggtgcat gagcaagctg ctggatggaa tccaggataa   1260

ctacaccttt gcacaaccag gaatccagaa gaaggtgaag gcactggaag agcttgtcag   1320

ccggattgat gagcaggtac ataatcactt caggaggtac gaggtagaat acctgcagtt   1380

tgccttccgc tggatgaaca acctgcttat gcgggagctt cctcttcgct gcaccatccg   1440

cctgtgggac acatatcagt ctgaaccaga agggttctcc cactttcatc tctacgtgtg   1500

tgcagccttc ttgatcaagt ggaggaaaga gatcttggat gaggaggatt ttcagggtct   1560

cctcatgctg ctacagaacc tacctacaat acactggggc aacgaagaaa ttgggctgct   1620

tctcgccgag gcatacagac tcaagtacat gtttgccgat gccccaaatc actaccgccg   1680

ataggtgctg tctcctccgg ggacccagac tgccttcatc tctgatggca gtctgatcac   1740

tgtggccact gtgcgagccg tggaccccgg ccaggaacca ctcctgttgt acaaagctca   1800

cacccaccgc ccaggtctta actttctggc atccaccact ccatgtctct ggatgtgtca   1860

cttggaccac tgtcagtatt ccatgccgcg tggatgggcc cagttctggg agaggacaga   1920

aaaggtggta cagggttgtc tgccccttta aaagaaactg gacaaagaag gggaaggctc   1980

agggtctcac ctcacattgt ccctacaagg acaggcccca actgataacc gttgcttttt   2040

tttttttgtg aacatagttt gatttgatca caggtcaaaa acgccttata ttttcgaaag   2100

actcctggcc cctcttccct cttcctggtt tcctagccgt tccccttctg ccccagtctg   2160

agccagtgag gggtagcttt ttaaaaccat tattctagat ggaggaggca ctgatgcttg   2220

taactctgga aagaggccta cacccaaggg ctaggaattt tatttttcct tttctcacca   2280

ggtgtctgca tgtgtgtgtg ggtgtgaatg tgtatacatg cccatcagca tttagtcaca   2340

tgtctgaatt tctgtgtcca gacgagcccc atcaaactag ttgggaaggg ccccagtgac   2400

caagtgtata agcatccctt gaagagggat tggggcaggg gaggcagaag gggctctcca   2460

gacccctttt ccatgatgac ccactccaag atattatgtg taaattgtgt tattatgtat   2520

atgggtaaag atgtacaaat atatgtcctc tttgtagcag atatgatttt atatttataa   2580

tgtgcatcaa catgtgaaag caatctaggt cactagcaca gaggaagttg ccaggaaggt   2640

ggcttcagca cctccaggtt ggttctgggt gtcctgctgt gaggggtaga acgggaggct   2700

gctgaagtga gtagctgagc agctggagcc atcccaagca tcagtgtctc agagtcctcc   2760

tcgccccttt cttcaccccg ccccccaacc cccagacttt cctggagcat ctgccctttg   2820

ctcctagcag cctccccagg aagggactgc agaggcgggc aagccctctc tatgtgtttt   2880

tatccccacc ttccccggaa tctggggagg gcttttgttt ttacgttttc aagttcagca   2940

ttgtattcgg acagaagctg tgactgaaga ctcagtgcca aggaaagggg cttcttgtgt   3000

gtccctcggg tttggggctc ttctcagaga gcagcactcc atatccctta ctgtcacctt   3060

cactccccac acagctcatg agatgtgtga cccctgtttg agttttggta tttggtagtg   3120

gagggtgggg ggatgggggc cagcagctgt catcctcctg ggaagccgag cagtgtccct   3180

ggtgggtaac accctcaagt ctctttgcca gtgaggcccc accacatcgg tgtgagttag   3240

gtttctcatc tggagctgtt tctcaggcat tcttcccaac cctcttcctt ttccccttcg   3300

gtgtgcctca gtggtctcct tcatagagtg agagggcttg agaccctccc tcaaccggac   3360

taattaaaga aagacacttg tgttcccaag tggtggtttt atttttttag tttttatgtt   3420

tgtatgggaa attgtggata aagtgaaaag aattgtaaat aaatggtgta tttcctcctc   3480

ca                                                                  3482


<210>  2311
<211>  505
<212>  PRT
<213>  Homo sapiens

<400>  2311


Met Ala Ala Glu Asn Ser Lys Gln Phe Trp Lys Arg Ser Ala Lys Leu 
1               5                   10                  15      


Pro Gly Ser Ile Gln Pro Val Tyr Gly Ala Gln His Pro Pro Leu Asp 
            20                  25                  30          


Pro Arg Leu Thr Lys Asn Phe Ile Lys Glu Arg Ser Lys Val Asn Thr 
        35                  40                  45              


Val Pro Leu Lys Asn Lys Lys Ala Ser Ser Phe His Glu Phe Ala Arg 
    50                  55                  60                  


Asn Thr Ser Asp Ala Trp Asp Ile Gly Asp Asp Glu Glu Glu Asp Phe 
65                  70                  75                  80  


Ser Ser Pro Ser Phe Gln Thr Leu Asn Ser Lys Val Ala Leu Ala Thr 
                85                  90                  95      


Ala Ala Gln Val Leu Glu Asn His Ser Lys Leu Arg Val Lys Pro Glu 
            100                 105                 110         


Arg Ser Gln Ser Thr Thr Ser Asp Val Pro Ala Asn Tyr Lys Val Ile 
        115                 120                 125             


Lys Ser Ser Ser Asp Ala Gln Leu Ser Arg Asn Ser Ser Asp Thr Cys 
    130                 135                 140                 


Leu Arg Asn Pro Leu His Lys Gln Gln Ser Leu Pro Leu Arg Pro Ile 
145                 150                 155                 160 


Ile Pro Leu Val Ala Arg Ile Ser Asp Gln Asn Ala Ser Gly Ala Pro 
                165                 170                 175     


Pro Met Thr Val Arg Glu Lys Thr Arg Leu Glu Lys Phe Arg Gln Leu 
            180                 185                 190         


Leu Ser Ser Gln Asn Thr Asp Leu Asp Glu Leu Arg Lys Cys Ser Trp 
        195                 200                 205             


Pro Gly Val Pro Arg Glu Val Arg Pro Ile Thr Trp Arg Leu Leu Ser 
    210                 215                 220                 


Gly Tyr Leu Pro Ala Asn Thr Glu Arg Arg Lys Leu Thr Leu Gln Arg 
225                 230                 235                 240 


Lys Arg Glu Glu Tyr Phe Gly Phe Ile Glu Gln Tyr Tyr Asp Ser Arg 
                245                 250                 255     


Asn Glu Glu His His Gln Asp Thr Tyr Arg Gln Ile His Ile Asp Ile 
            260                 265                 270         


Pro Arg Thr Asn Pro Leu Ile Pro Leu Phe Gln Gln Pro Leu Val Gln 
        275                 280                 285             


Glu Ile Phe Glu Arg Ile Leu Phe Ile Trp Ala Ile Arg His Pro Ala 
    290                 295                 300                 


Ser Gly Tyr Val Gln Gly Ile Asn Asp Leu Val Thr Pro Phe Phe Val 
305                 310                 315                 320 


Val Phe Leu Ser Glu Tyr Val Glu Glu Asp Val Glu Asn Phe Asp Val 
                325                 330                 335     


Thr Asn Leu Ser Gln Asp Met Leu Arg Ser Ile Glu Ala Asp Ser Phe 
            340                 345                 350         


Trp Cys Met Ser Lys Leu Leu Asp Gly Ile Gln Asp Asn Tyr Thr Phe 
        355                 360                 365             


Ala Gln Pro Gly Ile Gln Lys Lys Val Lys Ala Leu Glu Glu Leu Val 
    370                 375                 380                 


Ser Arg Ile Asp Glu Gln Val His Asn His Phe Arg Arg Tyr Glu Val 
385                 390                 395                 400 


Glu Tyr Leu Gln Phe Ala Phe Arg Trp Met Asn Asn Leu Leu Met Arg 
                405                 410                 415     


Glu Leu Pro Leu Arg Cys Thr Ile Arg Leu Trp Asp Thr Tyr Gln Ser 
            420                 425                 430         


Glu Pro Glu Gly Phe Ser His Phe His Leu Tyr Val Cys Ala Ala Phe 
        435                 440                 445             


Leu Ile Lys Trp Arg Lys Glu Ile Leu Asp Glu Glu Asp Phe Gln Gly 
    450                 455                 460                 


Leu Leu Met Leu Leu Gln Asn Leu Pro Thr Ile His Trp Gly Asn Glu 
465                 470                 475                 480 


Glu Ile Gly Leu Leu Leu Ala Glu Ala Tyr Arg Leu Lys Tyr Met Phe 
                485                 490                 495     


Ala Asp Ala Pro Asn His Tyr Arg Arg 
            500                 505 

<210>  2312
<211>  1448
<212>  DNA
<213>  Homo sapiens

<400>  2312
cactttaatg ttgttagttt ggagggaatt ggtggggagt gggcttgatg ctgagttttt     60

agcagccacc ctatttggga ctcaagctgc ctcctggccc catcttcgta gatgaagcag    120

cctcccatgt gataggcagc tgagaaatat tgaggctctt gccagcagtg tgtggagata    180

gcccagtcag gatgctgagc tgctttcagt gacacttgaa gacagtgtgt gcgtttggtg    240

ggacagtggt gcgtccagtg ctggatttcc tgtcattgca ggagaagagg atgtggagaa    300

ctttgacgtg accaacttgt ctcaagacat gctgcgaagc attgaggctg acagcttttg    360

gtgcatgagc aagctgctgg atggaatcca ggataactac acctttgcac aaccaggaat    420

ccagaagaag gtgaaggcac tggaagagct tgtcagccgg attgatgagc aggtacataa    480

tcacttcagg aggtacgagg tagaatacct gcagtttgcc ttccgctgga tgaacaacct    540

gcttatgcgg gagcttcctc ttcgctgcac catccgcctg tgggacacat atcagtctga    600

accagaaggg ttctcccact ttcatctcta cgtgtgtgca gccttcttga tcaagtggag    660

gaaagagatc ttggatgagg aggattttca gcccttattg cagagtaaaa ttagtcaact    720

cttagtcacc agctgggtca cactggtggc tgggaaagac caagaagagg cagaggaaga    780

ggtggcaccg atgataaaaa tccattcaag aatttagctg tgacacatct acagcaggtt    840

caaatctctc agctgtaaga caaactggat actttataag gactgtggcc tattatgcac    900

caaaatgcct tactgaaatt gtctggatga gctgcctgct gggtccagtg atacattagt    960

aaacgaagaa gttgaaatag aaggctaaca tatgctttgg atcgcttggc agtgtgacac   1020

caatatggca tcaagcctta ctatgagtcc aaggacttaa tgactaaata aaagtaaaaa   1080

tgaacaaaaa aaaaaagtga atgcttctag atttccttca aacagcctct tttatgactt   1140

ctcttctttt tgttccttct actttatgcc ttacttctct tctcacacca gggcaggcag   1200

tatatagtct agtaattatg agcacatgcc cagattgggc tcaaatccct ggctagcact   1260

accctgtgac cctaggcaag ttccttaacc tctgtgcctc aatttcctca tctgtaaaat   1320

ggaagttaat atgtatctca tagagtagat gtaggattaa acaaactagt acaaagtaca   1380

tgtgaaacat ctagagcccc atctgttatg taataagtgc tcaataaata ataaatgccg   1440

ttatactg                                                            1448


<210>  2313
<211>  162
<212>  PRT
<213>  Homo sapiens

<400>  2313


Met Leu Arg Ser Ile Glu Ala Asp Ser Phe Trp Cys Met Ser Lys Leu 
1               5                   10                  15      


Leu Asp Gly Ile Gln Asp Asn Tyr Thr Phe Ala Gln Pro Gly Ile Gln 
            20                  25                  30          


Lys Lys Val Lys Ala Leu Glu Glu Leu Val Ser Arg Ile Asp Glu Gln 
        35                  40                  45              


Val His Asn His Phe Arg Arg Tyr Glu Val Glu Tyr Leu Gln Phe Ala 
    50                  55                  60                  


Phe Arg Trp Met Asn Asn Leu Leu Met Arg Glu Leu Pro Leu Arg Cys 
65                  70                  75                  80  


Thr Ile Arg Leu Trp Asp Thr Tyr Gln Ser Glu Pro Glu Gly Phe Ser 
                85                  90                  95      


His Phe His Leu Tyr Val Cys Ala Ala Phe Leu Ile Lys Trp Arg Lys 
            100                 105                 110         


Glu Ile Leu Asp Glu Glu Asp Phe Gln Pro Leu Leu Gln Ser Lys Ile 
        115                 120                 125             


Ser Gln Leu Leu Val Thr Ser Trp Val Thr Leu Val Ala Gly Lys Asp 
    130                 135                 140                 


Gln Glu Glu Ala Glu Glu Glu Val Ala Pro Met Ile Lys Ile His Ser 
145                 150                 155                 160 


Arg Ile 
        

<210>  2314
<211>  2611
<212>  DNA
<213>  Homo sapiens

<400>  2314
atgttgttag tttggaggga attggtgggg agtgggcttg atgctgagtt tttagcagcc     60

accctatttg ggactcaagc tgcctcctgg ccccatcttc gtagatgaag cagcctccca    120

tgtgataggc agctgagaaa tattgaggct cttgccagca gtgtgtggag atagcccagt    180

caggatgctg agctgctttc agtgacactt gaagacagtg tgtgcgtttg gtgggacagt    240

ggtgcgtcca gtgctggatt tcctgtcatt gcaggagaag aggatgtgga gaactttgac    300

gtgaccaact tgtctcaaga catgctgcga agcattgagg ctgacagctt ttggtgcatg    360

agcaagctgc tggatggaat ccaggataac tacacctttg cacaaccagg aatccagaag    420

aaggtgaagg cactggaaga gcttgtcagc cggattgatg agcaggtaca taatcacttc    480

aggaggtacg aggtagaata cctgcagttt gccttccgct ggatgaacaa cctgcttatg    540

cgggagcttc ctcttcgctg caccatccgc ctgtgggaca catatcagtc tgaaccagaa    600

gggttctccc actttcatct ctacgtgtgt gcagccttct tgatcaagtg gaggaaagag    660

atcttggatg aggaggattt tcagggtctc ctcatgctgc tacagaacct acctacaata    720

cactggggca acgaagaaat tgggctgctt ctcgccgagg catacagact caagtacatg    780

tttgccgatg ccccaaatca ctaccgccga taggtgctgt ctcctccggg gacccagact    840

gccttcatct ctgatggcag tctgatcact gtggccactg tgcgagccgt ggaccccggc    900

caggaaccac tcctgttgta caaagctcac acccaccgcc caggtcttaa ctttctggca    960

tccaccactc catgtctctg gatgtgtcac ttggaccact gtcagtattc catgccgcgt   1020

ggatgggccc agttctggga gaggacagaa aaggtggtac agggttgtct gcccctttaa   1080

aagaaactgg acaaagaagg ggaaggctca gggtctcacc tcacattgtc cctacaagga   1140

caggccccaa ctgataaccg ttgctttttt ttttttgtga acatagtttg atttgatcac   1200

aggtcaaaaa cgccttatat tttcgaaaga ctcctggccc ctcttccctc ttcctggttt   1260

cctagccgtt ccccttctgc cccagtctga gccagtgagg ggtagctttt taaaaccatt   1320

attctagatg gaggaggcac tgatgcttgt aactctggaa agaggcctac acccaagggc   1380

taggaatttt atttttcctt ttctcaccag gtgtctgcat gtgtgtgtgg gtgtgaatgt   1440

gtatacatgc ccatcagcat ttagtcacat gtctgaattt ctgtgtccag acgagcccca   1500

tcaaactagt tgggaagggc cccagtgacc aagtgtataa gcatcccttg aagagggatt   1560

ggggcagggg aggcagaagg ggctctccag accccttttc catgatgacc cactccaaga   1620

tattatgtgt aaattgtgtt attatgtata tgggtaaaga tgtacaaata tatgtcctct   1680

ttgtagcaga tatgatttta tatttataat gtgcatcaac atgtgaaagc aatctaggtc   1740

actagcacag aggaagttgc caggaaggtg gcttcagcac ctccaggttg gttctgggtg   1800

tcctgctgtg aggggtagaa cgggaggctg ctgaagtgag tagctgagca gctggagcca   1860

tcccaagcat cagtgtctca gagtcctcct cgcccctttc ttcaccccgc cccccaaccc   1920

ccagactttc ctggagcatc tgccctttgc tcctagcagc ctccccagga agggactgca   1980

gaggcgggca agccctctct atgtgttttt atccccacct tccccggaat ctggggaggg   2040

cttttgtttt tacgttttca agttcagcat tgtattcgga cagaagctgt gactgaagac   2100

tcagtgccaa ggaaaggggc ttcttgtgtg tccctcgggt ttggggctct tctcagagag   2160

cagcactcca tatcccttac tgtcaccttc actccccaca cagctcatga gatgtgtgac   2220

ccctgtttga gttttggtat ttggtagtgg agggtggggg gatgggggcc agcagctgtc   2280

atcctcctgg gaagccgagc agtgtccctg gtgggtaaca ccctcaagtc tctttgccag   2340

tgaggcccca ccacatcggt gtgagttagg tttctcatct ggagctgttt ctcaggcatt   2400

cttcccaacc ctcttccttt tccccttcgg tgtgcctcag tggtctcctt catagagtga   2460

gagggcttga gaccctccct caaccggact aattaaagaa agacacttgt gttcccaagt   2520

ggtggtttta tttttttagt ttttatgttt gtatgggaaa ttgtggataa agtgaaaaga   2580

attgtaaata aatggtgtat ttcctcctcc a                                  2611


<210>  2315
<211>  163
<212>  PRT
<213>  Homo sapiens

<400>  2315


Met Leu Arg Ser Ile Glu Ala Asp Ser Phe Trp Cys Met Ser Lys Leu 
1               5                   10                  15      


Leu Asp Gly Ile Gln Asp Asn Tyr Thr Phe Ala Gln Pro Gly Ile Gln 
            20                  25                  30          


Lys Lys Val Lys Ala Leu Glu Glu Leu Val Ser Arg Ile Asp Glu Gln 
        35                  40                  45              


Val His Asn His Phe Arg Arg Tyr Glu Val Glu Tyr Leu Gln Phe Ala 
    50                  55                  60                  


Phe Arg Trp Met Asn Asn Leu Leu Met Arg Glu Leu Pro Leu Arg Cys 
65                  70                  75                  80  


Thr Ile Arg Leu Trp Asp Thr Tyr Gln Ser Glu Pro Glu Gly Phe Ser 
                85                  90                  95      


His Phe His Leu Tyr Val Cys Ala Ala Phe Leu Ile Lys Trp Arg Lys 
            100                 105                 110         


Glu Ile Leu Asp Glu Glu Asp Phe Gln Gly Leu Leu Met Leu Leu Gln 
        115                 120                 125             


Asn Leu Pro Thr Ile His Trp Gly Asn Glu Glu Ile Gly Leu Leu Leu 
    130                 135                 140                 


Ala Glu Ala Tyr Arg Leu Lys Tyr Met Phe Ala Asp Ala Pro Asn His 
145                 150                 155                 160 


Tyr Arg Arg 
            

<210>  2316
<211>  1169
<212>  DNA
<213>  Homo sapiens

<400>  2316
gaaggggaag gctcagggtc tcacctcaca ttgtccctac aaggacaggc cccaactgat     60

aaccgttgct tttttttttt tgtgaacata gtttgatttg atcacaggtc aaaaacgcct    120

tatattttcg aaagactcct ggcccctctt ccctcttcct ggtttcctag ccgttcccct    180

tctgccccag tctgagccag tgaggggtag ctttttaaaa ccattattct agatggagga    240

ggcactgatg cttgtaactc tggaaagagg cctacaccca agggctagga attttatttt    300

tccttttctc accaggtgtc tgcatgtgtg tgtgggtgtg aatgtgtata catgcccatc    360

agcatttagt cacatgtctg aatttctgtg tccagacgag ccccatcaaa ctagttggga    420

agggccccag tgaccaagtg tataagcatc cccctttctt caccccgccc cccaaccccc    480

agactttcct ggagcatctg ccctttgctc ctagcagcct ccccaggaag ggactgcaga    540

ggcgggcaag ccctctctat gtgtttttat ccccaccttc cccggaatct ggggagggct    600

tttgttttta cgttttcaag ttcagcattg tattcggaca gaagctgtga ctgaagactc    660

agtgccaagg aaaggggctt cttgtgtgtc cctcgggttt ggggctcttc tcagagagca    720

gcactccata tcccttactg tcaccttcac tccccacaca gctcatgaga tgtgtgaccc    780

ctgtttgagt tttggtattt ggtagtggag ggtgggggga tgggggccag cagctgtcat    840

cctcctggga agccgagcag tgtccctggt gggtaacacc ctcaagtctc tttgccagtg    900

aggccccacc acatcggtgt gagttaggtt tctcatctgg agctgtttct caggcattct    960

tcccaaccct cttccttttc cccttcggtg tgcctcagtg gtctccttca tagagtgaga   1020

gggcttgaga ccctccctca accggactaa ttaaagaaag acacttgtgt tcccaagtgg   1080

tggttttatt tttttagttt ttatgtttgt atgggaaatt gtggataaag tgaaaagaat   1140

tgtaaataaa tggtgtattt cctcctcca                                     1169


<210>  2317
<211>  102
<212>  PRT
<213>  Homo sapiens

<400>  2317


Met Cys Ile His Ala His Gln His Leu Val Thr Cys Leu Asn Phe Cys 
1               5                   10                  15      


Val Gln Thr Ser Pro Ile Lys Leu Val Gly Lys Gly Pro Ser Asp Gln 
            20                  25                  30          


Val Tyr Lys His Pro Pro Phe Phe Thr Pro Pro Pro Asn Pro Gln Thr 
        35                  40                  45              


Phe Leu Glu His Leu Pro Phe Ala Pro Ser Ser Leu Pro Arg Lys Gly 
    50                  55                  60                  


Leu Gln Arg Arg Ala Ser Pro Leu Tyr Val Phe Leu Ser Pro Pro Ser 
65                  70                  75                  80  


Pro Glu Ser Gly Glu Gly Phe Cys Phe Tyr Val Phe Lys Phe Ser Ile 
                85                  90                  95      


Val Phe Gly Gln Lys Leu 
            100         

<210>  2318
<211>  2134
<212>  DNA
<213>  Homo sapiens

<400>  2318
cttgcgcagg cgtagtgctc ctgcttcctg gccgagggcg ggcgagcgga gcctgctttc     60

gcagcgatcg cgagcgtgtg gcgattgctt ctgtctgtta tttagatatg gaagctgagg    120

ggatgcacag aggcagccag aacctaggtc agggtctcgc tcggtgctga ccgcccccgg    180

ggtcgagtag gcgatggggg agcccggctt cttcgtcaca ggagaccgcg ccggtggccg    240

gagctggtgc ctgcggcggg tggggatgag cgccgggtgg ctgctgctgg aagatgggtg    300

cgaggtgact gtaggacgag gatttggtgt cacataccaa ctggtatcaa aaatctgccc    360

cctgatgatt tctcgaaacc actgtgtttt gaagcagaat cctgagggcc aatggacaat    420

tatggacaac aagagtctaa atggtgtttg gctgaacaga gcgcgtctgg aacctttaag    480

ggtctattcc attcatcagg gagactacat ccaacttgga gtgcctctgg aaaataagga    540

gaatgcggag tatgaatatg aagttactga agaagactgg gagacaatat atccttgtct    600

ttccccaaag aatgaccaaa tgatagaaaa aaataaggaa ttgagaacta aaaggaaatt    660

cagtttggat gaattagcag gtcctggagc tgaaggcccc tcaaatttga aatccaaaat    720

aaataaagtg tcttgtgaat ctggtcagcc agtgaaatca caggggaaag gtgaagtggc    780

cagtacaccc tctgacaatt tggatcctaa gttgactgcc cttgagccaa gtaagaccac    840

aggggctccc atttaccctg gcttccccaa agtcacagag gttcatcatg agcagaaagc    900

ctcaaactct tcagcatctc agagaagctt acagatgttt aaggtgacca tgtccaggat    960

tctgaggctc aaaatacaga tgcaggaaaa acatgaagcc gttatgaatg tgaaaaagca   1020

gacccaaaag gggaactcaa agaaagttgt gcaaatggag caggaacttc aggacttaca   1080

gtcccagctg tgtgcagagc aggctcagca gcaggcaaga gtggagcaac tagagaagac   1140

tttccaggaa gaggaacagc atcttcaggg tttggagata gcccaaggag aaaaggacct   1200

gaagcaacag ctggcccagg ctctgcagga gcattgggct ctaatggaag agctaaatcg   1260

cagcaagaag gactttgaag caatcattca agccaagaac aaagaattag agcagaccaa   1320

ggaagagaag gagaagatgc aagcacagaa ggaagaagtt cttagccaca tgaatgatgt   1380

gctagagaat gagctccaat gtattatttg ttcagaatac ttcattgagg ctgtcacctt   1440

gaactgtgcc cacagtttct gctcctactg tatcaatgaa tggatgaagc ggaagataga   1500

atgccccatt tgtcggaagg acattaagtc caaaacgtac tctttggttc tggacaattg   1560

cattaataag atggtaaata atctgagctc agaagtgaaa gaacgacgaa ttgttctcat   1620

tagggaacga aaagcaaaga gattgttctg aagaccgtgc tctaagggca tttgaaagac   1680

tgccaggtag tgcgagcctg agatggtctg gaggattctc tctagccgtg actccgctgc   1740

tctgaaggtc aactgagaag tcttgtggga cagagacttg agttaggaag ccctcagtca   1800

cttgccttcc acggtggcca gccctgctgc catcattggc tgaagcacca ccaggattca   1860

cggcacccaa ctgcttcagg gtacttcgta gactctgcct cactacatgt cgaaagagtt   1920

atttgagttc tcttctgttt ttttttaatt tgttgttgtt gttactgttt tgatacctcg   1980

gaaacacctc cgttgacagt tgttttggat aggttgggtg taccccatgg ctgcctctga   2040

aggcagtgtc tattttgaga ggatggctta cctcttcttt gtgaaaatac tatctcattt   2100

cctggaaata aaatgtaaaa cctgtcagtt gctc                               2134


<210>  2319
<211>  485
<212>  PRT
<213>  Homo sapiens

<400>  2319


Met Gly Glu Pro Gly Phe Phe Val Thr Gly Asp Arg Ala Gly Gly Arg 
1               5                   10                  15      


Ser Trp Cys Leu Arg Arg Val Gly Met Ser Ala Gly Trp Leu Leu Leu 
            20                  25                  30          


Glu Asp Gly Cys Glu Val Thr Val Gly Arg Gly Phe Gly Val Thr Tyr 
        35                  40                  45              


Gln Leu Val Ser Lys Ile Cys Pro Leu Met Ile Ser Arg Asn His Cys 
    50                  55                  60                  


Val Leu Lys Gln Asn Pro Glu Gly Gln Trp Thr Ile Met Asp Asn Lys 
65                  70                  75                  80  


Ser Leu Asn Gly Val Trp Leu Asn Arg Ala Arg Leu Glu Pro Leu Arg 
                85                  90                  95      


Val Tyr Ser Ile His Gln Gly Asp Tyr Ile Gln Leu Gly Val Pro Leu 
            100                 105                 110         


Glu Asn Lys Glu Asn Ala Glu Tyr Glu Tyr Glu Val Thr Glu Glu Asp 
        115                 120                 125             


Trp Glu Thr Ile Tyr Pro Cys Leu Ser Pro Lys Asn Asp Gln Met Ile 
    130                 135                 140                 


Glu Lys Asn Lys Glu Leu Arg Thr Lys Arg Lys Phe Ser Leu Asp Glu 
145                 150                 155                 160 


Leu Ala Gly Pro Gly Ala Glu Gly Pro Ser Asn Leu Lys Ser Lys Ile 
                165                 170                 175     


Asn Lys Val Ser Cys Glu Ser Gly Gln Pro Val Lys Ser Gln Gly Lys 
            180                 185                 190         


Gly Glu Val Ala Ser Thr Pro Ser Asp Asn Leu Asp Pro Lys Leu Thr 
        195                 200                 205             


Ala Leu Glu Pro Ser Lys Thr Thr Gly Ala Pro Ile Tyr Pro Gly Phe 
    210                 215                 220                 


Pro Lys Val Thr Glu Val His His Glu Gln Lys Ala Ser Asn Ser Ser 
225                 230                 235                 240 


Ala Ser Gln Arg Ser Leu Gln Met Phe Lys Val Thr Met Ser Arg Ile 
                245                 250                 255     


Leu Arg Leu Lys Ile Gln Met Gln Glu Lys His Glu Ala Val Met Asn 
            260                 265                 270         


Val Lys Lys Gln Thr Gln Lys Gly Asn Ser Lys Lys Val Val Gln Met 
        275                 280                 285             


Glu Gln Glu Leu Gln Asp Leu Gln Ser Gln Leu Cys Ala Glu Gln Ala 
    290                 295                 300                 


Gln Gln Gln Ala Arg Val Glu Gln Leu Glu Lys Thr Phe Gln Glu Glu 
305                 310                 315                 320 


Glu Gln His Leu Gln Gly Leu Glu Ile Ala Gln Gly Glu Lys Asp Leu 
                325                 330                 335     


Lys Gln Gln Leu Ala Gln Ala Leu Gln Glu His Trp Ala Leu Met Glu 
            340                 345                 350         


Glu Leu Asn Arg Ser Lys Lys Asp Phe Glu Ala Ile Ile Gln Ala Lys 
        355                 360                 365             


Asn Lys Glu Leu Glu Gln Thr Lys Glu Glu Lys Glu Lys Met Gln Ala 
    370                 375                 380                 


Gln Lys Glu Glu Val Leu Ser His Met Asn Asp Val Leu Glu Asn Glu 
385                 390                 395                 400 


Leu Gln Cys Ile Ile Cys Ser Glu Tyr Phe Ile Glu Ala Val Thr Leu 
                405                 410                 415     


Asn Cys Ala His Ser Phe Cys Ser Tyr Cys Ile Asn Glu Trp Met Lys 
            420                 425                 430         


Arg Lys Ile Glu Cys Pro Ile Cys Arg Lys Asp Ile Lys Ser Lys Thr 
        435                 440                 445             


Tyr Ser Leu Val Leu Asp Asn Cys Ile Asn Lys Met Val Asn Asn Leu 
    450                 455                 460                 


Ser Ser Glu Val Lys Glu Arg Arg Ile Val Leu Ile Arg Glu Arg Lys 
465                 470                 475                 480 


Ala Lys Arg Leu Phe 
                485 

<210>  2320
<211>  5425
<212>  DNA
<213>  Homo sapiens

<400>  2320
cttgcgcagg cgtagtgctc ctgcttcctg gccgagggcg ggcgagcgga gcctgctttc     60

gcagcgatcg cgagcgtgtg gcgattgctt ctgtctgtta tttagatatg gaagctgagg    120

ggatgcacag aggcagccag aacctaggtc agggtctcgc tcggtgctga ccgcccccgg    180

ggtcgagtag gcgatggggg agcccggctt cttcgtcaca ggagaccgcg ccggtggccg    240

gagctggtgc ctgcggcggg tggggatgag cgccgggtgg ctgctgctgg aagatgggtg    300

cgaggtgact gtaggacgag gatttggtgt cacataccaa ctggtatcaa aaatctgccc    360

cctgatgatt tctcgaaacc actgtgtttt gaagcagaat cctgagggcc aatggacaat    420

tatggacaac aagagtctaa atggtgtttg gctgaacaga gcgcgtctgg aacctttaag    480

ggtctattcc attcatcagg gagactacat ccaacttgga gtgcctctgg aaaataagga    540

gaatgcggag tatgaatatg aagttactga agaagactgg gagacaatat atccttgtct    600

ttccccaaag aatgaccaaa tgatagaaaa aaataaggaa ttgagaacta aaaggaaatt    660

cagtttggat gaattagcag gtcctggagc tgaaggcccc tcaaatttga aatccaaaat    720

aaataaagtg tcttgtgaat ctggtcagcc agtgaaatca caggggaaag gtgaagtggc    780

cagtacaccc tctgacaatt tggatcctaa gttgactgcc cttgagccaa gtaagaccac    840

aggggctccc atttaccctg gcttccccaa agtcacagag gttcatcatg agcagaaagc    900

ctcaaactct tcagcatctc agagaagctt acagatgttt aaggtgacca tgtccaggat    960

tctgaggctc aaaatacaga tgcaggaaaa acatgaagcc gttatgaatg tgaaaaagca   1020

gacccaaaag gggaactcaa agaaagttgt gcaaatggag caggaacttc aggacttaca   1080

gtcccagctg tgtgcagagc aggctcagca gcaggcaaga gtggagcaac tagagaagac   1140

tttccaggaa gaggaacagc atcttcaggg tttggagata gcccaaggag aaaaggacct   1200

gaagcaacag ctggcccagg ctctgcagga gcattgggct ctaatggaag agctaaatcg   1260

cagcaagaag gactttgaag caatcattca agccaagaac aaagaattag agcagaccaa   1320

ggaagagaag gagaagatgc aagcacagaa ggaagaagtt cttagccaca tgaatgatgt   1380

gctagagaat gagctccaat gtattatttg ttcagaatac ttcattgagc aaagagattg   1440

ttctgaagac cgtgctctaa gggcatttga aagactgcca ggtagtgcga gcctgagatg   1500

gtctggagga ttctctctag ccgtgactcc gctgctctga aggtcaactg agaagtcttg   1560

tgggacagag acttgagtta ggaagccctc agtcacttgc cttccacggt ggccagccct   1620

gctgccatca ttggctgaag caccaccagg attcacggca cccaactgct tcagggtact   1680

tcgtagactc tgcctcacta catgtcgaaa gagttatttg agttctcttc tgtttttttt   1740

taatttgttg ttgttgttac tgttttgata cctcggaaac acctccgttg acagttgttt   1800

tggataggtt gggtgtaccc catggctgcc tctgaaggca gtgtctattt tgagaggatg   1860

gcttacctct tctttgtgaa aatactatct catttcctgg aaataaaatg taaaacctgt   1920

cagttgctca gctgggcttt ggtgtattta ccttccttcc cttcctgctc ccagacagtc   1980

tcacaagtaa acaccagcag ctcatagatt acaaccaaga aagtgactgt atcagatgat   2040

agacttcaag tgaatgtcag cctaagaggc caagctgcag atcgtggcaa cagatgagct   2100

ctgttaacct cctgactgtc gtgtttcctt tttattacag aggtgggtca ctgtttacct   2160

tgtttcaggg gtgggagaaa ctcctttcct tcagctggca tttgaatgtt tccaaatcta   2220

ttttatctga cgtcatgaac acacaggcaa tgattttatg acaacttgat gtgctttttt   2280

ctttattttt cttttacatt agaagttttc tctcttttct ccacctctcc tttattttta   2340

attttaattt taatttttga aacaagatct gactctgttg cccaagctgg agtacagtag   2400

tgcaatctca gctcactgca acctccacct cccagactca agccatcctc ccacctcaac   2460

ctcccaagta gctgggacta caggcatatg ccatcacacc cagctaattt ttgtttttct   2520

gtagagacag ggtttcacca tgttggccag gctggtctca aattcctgac cttaagtgat   2580

ccacctgcct aggcctctaa aatgctggga ttacaggcgt gagccaccac gcccagccta   2640

taccccatgt attttcataa agggttggaa actattgatt gccaactttt taaggatggt   2700

agggattttt tctttgttga atatactgtg aattttggga ttctggagtc cttagtcttc   2760

atttccattc ttctgcccat gattactgat caaaatactg gtagagtcat ggaggaagta   2820

agttaaatgt ggaaaaaatg ctttaaaagt acttactata accacatcat aagaattctg   2880

gaaaaataga gaacaaaagg aaaagattgt taccaccttg atttaataac ttcttgtttc   2940

cccatacatg tgttttgttt atagattgca tgggtatatg tcaattttta tatgttctgt   3000

gtttagttta catattgtaa ttcattttta agagagtaca gacatacact ttttgagtag   3060

gcaatatgtt cacatagttt gaaattaaag gtacaaaatg gcgtagaatg aaatgcctct   3120

caccctttcc ccacagcgac tacttcccac tcagaggcaa caagtattac agttgcttgt   3180

atattcttcc agagatctct gtctatacaa gcaaaaacac atgtggtctt tttccttgct   3240

ttgcacaaat ggtaaactgt acgctattct gaaccttgct tttttcagat atatgttggc   3300

aacagttcca tgtcagtaca tagtttcctt tctttattac agctgcctgt tttttcattg   3360

tgtatttgca ccatcattta cttttctggc ttacttttga tagaaatcta ggttggttca   3420

aaccttttta ctcttaaaac aatgctgcag ttaacaccct tgtacatata tctttagaga   3480

gaagatattt taaaaagaaa taccttttta aaaattattt tattattttt taatagagac   3540

tatgttgcct aggctggtct tgaaattctg ggctaaagca atcctaccac cttggcctcc   3600

caaagtgctg agattacagg catgagccat tgcacctggc caagaagaga catcttgact   3660

tgagcctgaa gactatgtac agagactgac ctcacagact gaccattcca tcccacagct   3720

gctggacata gagtgatttg cagcccctcc tttcagagta ccacatccct ctcaagtgtt   3780

ccacaacatc taggaaagtg agctcttaaa gacagactaa aaagagtaat aaatcaatac   3840

aacaacatta aaagccagac tagcggagtt tgaatcttgg ccctgctgtt agtaactgtg   3900

tgagccttgg gcaagttact cagcctcctt gtgtcttggt tttggtttct tcatctctaa   3960

gtaattatat ctgtcattat tgccctgatc acaaacaaaa gcctgaatgt actatgttta   4020

aaagacaaac caaaaattaa cccaaacttg cattatttgt ctgagctaca gaatgttctt   4080

tccttggaga gatatctgat attaaacatc atctgcattt tacttgccta gaaaatacac   4140

ggtaactttt ctgccttgca gcatcaaact atagtacagc tgagccccag tgctgtgcag   4200

tctgactcta attaaaggca ccttctttac agcagggctc tggggaactg gaaaaggggg   4260

tttgtttcat tatctggttt tattaagcag atgaatgcag ccagctatat gaagcacttt   4320

gcagtgaatg gcaggtgtcc catatctggt tatgttaacc tagaaagggc tcactctacc   4380

tctaggcatg tttcatccca acaatcagac tgtgccaaag caggggactt tgtcctttgt   4440

ggattgcata gctggatacc catcatctgt ttctctgatt ggaagctgct gttgtacaga   4500

aagacctgca tttccccctt gtctccagtt ctctcactac tttttcctcc tctgtgagtg   4560

accatccagg cagtcaccat aactgctgga gtgtctggga ttggtagctc tctccaactg   4620

cctgcttgct ctttacagcc tctctctgtg actggaatct ctccacctca tcgtatctaa   4680

ggataaccca gaaacatggg gtgtcctagg tatgtttatc tcgacactga accccctagg   4740

cttctgatga atccagtgat tagctaaatt tgacatagaa agtaagaagg aatgtctact   4800

ttgtattgtg gtcctaatct aagatcagga gaatcctgga attgttatct gtctcttgct   4860

ctgagataca gacttgttca taggtgtggg gcctgattgg aacaggatct gccattggtc   4920

acaataggtc aagggcttgt tctgaaccct agttagcttc attcagagaa agaaacttcc   4980

tacctggtca gctttttcag cttctccaac aaatgggagt tgaggcagta ggagtgtggg   5040

gttcttggga agacgatggg gccttgtatt aaggagaaat aatgaactat cttcttgatt   5100

cttccattga gaaaagcata tgaatcctag gaaagggctc agcctgtgat aggcattcaa   5160

taaatactcc aatgctgtca ttcctttgtc tacagcatcc ccaaacaatg taccagtgat   5220

gggctacctg agctcatcta gtcgccaagc agtatctcct gcttgctgct gctttactac   5280

attccagatg cccacctcat ccaatttcca gagccactat ctctgctgtc cactttcctt   5340

caggctctgt gaatacttca acctgctgtg atttggggcc gtttgtactc tgcatgtatt   5400

caataaattc aattcagcaa tagtt                                         5425


<210>  2321
<211>  448
<212>  PRT
<213>  Homo sapiens

<400>  2321


Met Gly Glu Pro Gly Phe Phe Val Thr Gly Asp Arg Ala Gly Gly Arg 
1               5                   10                  15      


Ser Trp Cys Leu Arg Arg Val Gly Met Ser Ala Gly Trp Leu Leu Leu 
            20                  25                  30          


Glu Asp Gly Cys Glu Val Thr Val Gly Arg Gly Phe Gly Val Thr Tyr 
        35                  40                  45              


Gln Leu Val Ser Lys Ile Cys Pro Leu Met Ile Ser Arg Asn His Cys 
    50                  55                  60                  


Val Leu Lys Gln Asn Pro Glu Gly Gln Trp Thr Ile Met Asp Asn Lys 
65                  70                  75                  80  


Ser Leu Asn Gly Val Trp Leu Asn Arg Ala Arg Leu Glu Pro Leu Arg 
                85                  90                  95      


Val Tyr Ser Ile His Gln Gly Asp Tyr Ile Gln Leu Gly Val Pro Leu 
            100                 105                 110         


Glu Asn Lys Glu Asn Ala Glu Tyr Glu Tyr Glu Val Thr Glu Glu Asp 
        115                 120                 125             


Trp Glu Thr Ile Tyr Pro Cys Leu Ser Pro Lys Asn Asp Gln Met Ile 
    130                 135                 140                 


Glu Lys Asn Lys Glu Leu Arg Thr Lys Arg Lys Phe Ser Leu Asp Glu 
145                 150                 155                 160 


Leu Ala Gly Pro Gly Ala Glu Gly Pro Ser Asn Leu Lys Ser Lys Ile 
                165                 170                 175     


Asn Lys Val Ser Cys Glu Ser Gly Gln Pro Val Lys Ser Gln Gly Lys 
            180                 185                 190         


Gly Glu Val Ala Ser Thr Pro Ser Asp Asn Leu Asp Pro Lys Leu Thr 
        195                 200                 205             


Ala Leu Glu Pro Ser Lys Thr Thr Gly Ala Pro Ile Tyr Pro Gly Phe 
    210                 215                 220                 


Pro Lys Val Thr Glu Val His His Glu Gln Lys Ala Ser Asn Ser Ser 
225                 230                 235                 240 


Ala Ser Gln Arg Ser Leu Gln Met Phe Lys Val Thr Met Ser Arg Ile 
                245                 250                 255     


Leu Arg Leu Lys Ile Gln Met Gln Glu Lys His Glu Ala Val Met Asn 
            260                 265                 270         


Val Lys Lys Gln Thr Gln Lys Gly Asn Ser Lys Lys Val Val Gln Met 
        275                 280                 285             


Glu Gln Glu Leu Gln Asp Leu Gln Ser Gln Leu Cys Ala Glu Gln Ala 
    290                 295                 300                 


Gln Gln Gln Ala Arg Val Glu Gln Leu Glu Lys Thr Phe Gln Glu Glu 
305                 310                 315                 320 


Glu Gln His Leu Gln Gly Leu Glu Ile Ala Gln Gly Glu Lys Asp Leu 
                325                 330                 335     


Lys Gln Gln Leu Ala Gln Ala Leu Gln Glu His Trp Ala Leu Met Glu 
            340                 345                 350         


Glu Leu Asn Arg Ser Lys Lys Asp Phe Glu Ala Ile Ile Gln Ala Lys 
        355                 360                 365             


Asn Lys Glu Leu Glu Gln Thr Lys Glu Glu Lys Glu Lys Met Gln Ala 
    370                 375                 380                 


Gln Lys Glu Glu Val Leu Ser His Met Asn Asp Val Leu Glu Asn Glu 
385                 390                 395                 400 


Leu Gln Cys Ile Ile Cys Ser Glu Tyr Phe Ile Glu Gln Arg Asp Cys 
                405                 410                 415     


Ser Glu Asp Arg Ala Leu Arg Ala Phe Glu Arg Leu Pro Gly Ser Ala 
            420                 425                 430         


Ser Leu Arg Trp Ser Gly Gly Phe Ser Leu Ala Val Thr Pro Leu Leu 
        435                 440                 445             

<210>  2322
<211>  5630
<212>  DNA
<213>  Homo sapiens

<400>  2322
cttgcgcagg cgtagtgctc ctgcttcctg gccgagggcg ggcgagcgga gcctgctttc     60

gcagcgatcg cgagcgtgtg gcgattgctt ctgtctgtta tttagatatg gaagctgagg    120

ggatgcacag aggcagccag aacctaggtc agggtctcgc tcggtgctga ccgcccccgg    180

ggtcgagtag gcgatggggg agcccggctt cttcgtcaca ggagaccgcg ccggtggccg    240

gagctggtgc ctgcggcggg tggggatgag cgccgggtgg ctgctgctgg aagatgggtg    300

cgaggtgact gtaggacgag gatttggtgt cacataccaa ctggtatcaa aaatctgccc    360

cctgatgatt tctcgaaacc actgtgtttt gaagcagaat cctgagggcc aatggacaat    420

tatggacaac aagagtctaa atggtgtttg gctgaacaga gcgcgtctgg aacctttaag    480

ggtctattcc attcatcagg gagactacat ccaacttgga gtgcctctgg aaaataagga    540

gaatgcggag tatgaatatg aagttactga agaagactgg gagacaatat atccttgtct    600

ttccccaaag aatgaccaaa tgatagaaaa aaataaggaa ttgagaacta aaaggaaatt    660

cagtttggat gaattagcag gtcctggagc tgaaggcccc tcaaatttga aatccaaaat    720

aaataaagtg tcttgtgaat ctggtcagcc agtgaaatca caggggaaag gtgaagtggc    780

cagtacaccc tctgacaatt tggatcctaa gttgactgcc cttgagccaa gtaagaccac    840

aggggctccc atttaccctg gcttccccaa agtcacagag gttcatcatg agcagaaagc    900

ctcaaactct tcagcatctc agagaagctt acagatgttt aaggtgacca tgtccaggat    960

tctgaggctc aaaatacaga tgcaggaaaa acatgaagcc gttatgaatg tgaaaaagca   1020

gacccaaaag gggaactcaa agaaagttgt gcaaatggag caggaacttc aggacttaca   1080

gtcccagctg tgtgcagagc aggctcagca gcaggcaaga gtggagcaac tagagaagac   1140

tttccaggaa gaggaacagc atcttcaggg tttggagata gcccaaggag aaaaggacct   1200

gaagcaacag ctggcccagg ctctgcagga gcattgggct ctaatggaag agctaaatcg   1260

cagcaagaag gactttgaag caatcattca agccaagaac aaagaattag agcagaccaa   1320

ggaagagaag gagaagatgc aagcacagaa ggaagaagtt cttagccaca tgaatgatgt   1380

gctagagaat gagctccaat gtattatttg ttcagaatac ttcattgagg ctgtcacctt   1440

gaactgtgcc cacagtttct gctcctactg tatcaatgaa tggatgaagc ggaagataga   1500

atgccccatt tgtcggaagg acattaagtc caaaacgtac tctttggttc tggacaattg   1560

cattaataag atggtaaata atctgagctc agaagtgaaa gaacgacgaa ttgttctcat   1620

tagggaacga aaagcaaaga gattgttctg aagaccgtgc tctaagggca tttgaaagac   1680

tgccaggtag tgcgagcctg agatggtctg gaggattctc tctagccgtg actccgctgc   1740

tctgaaggtc aactgagaag tcttgtggga cagagacttg agttaggaag ccctcagtca   1800

cttgccttcc acggtggcca gccctgctgc catcattggc tgaagcacca ccaggattca   1860

cggcacccaa ctgcttcagg gtacttcgta gactctgcct cactacatgt cgaaagagtt   1920

atttgagttc tcttctgttt ttttttaatt tgttgttgtt gttactgttt tgatacctcg   1980

gaaacacctc cgttgacagt tgttttggat aggttgggtg taccccatgg ctgcctctga   2040

aggcagtgtc tattttgaga ggatggctta cctcttcttt gtgaaaatac tatctcattt   2100

cctggaaata aaatgtaaaa cctgtcagtt gctcagctgg gctttggtgt atttaccttc   2160

cttcccttcc tgctcccaga cagtctcaca agtaaacacc agcagctcat agattacaac   2220

caagaaagtg actgtatcag atgatagact tcaagtgaat gtcagcctaa gaggccaagc   2280

tgcagatcgt ggcaacagat gagctctgtt aacctcctga ctgtcgtgtt tcctttttat   2340

tacagaggtg ggtcactgtt taccttgttt caggggtggg agaaactcct ttccttcagc   2400

tggcatttga atgtttccaa atctatttta tctgacgtca tgaacacaca ggcaatgatt   2460

ttatgacaac ttgatgtgct tttttcttta tttttctttt acattagaag ttttctctct   2520

tttctccacc tctcctttat ttttaatttt aattttaatt tttgaaacaa gatctgactc   2580

tgttgcccaa gctggagtac agtagtgcaa tctcagctca ctgcaacctc cacctcccag   2640

actcaagcca tcctcccacc tcaacctccc aagtagctgg gactacaggc atatgccatc   2700

acacccagct aatttttgtt tttctgtaga gacagggttt caccatgttg gccaggctgg   2760

tctcaaattc ctgaccttaa gtgatccacc tgcctaggcc tctaaaatgc tgggattaca   2820

ggcgtgagcc accacgccca gcctataccc catgtatttt cataaagggt tggaaactat   2880

tgattgccaa ctttttaagg atggtaggga ttttttcttt gttgaatata ctgtgaattt   2940

tgggattctg gagtccttag tcttcatttc cattcttctg cccatgatta ctgatcaaaa   3000

tactggtaga gtcatggagg aagtaagtta aatgtggaaa aaatgcttta aaagtactta   3060

ctataaccac atcataagaa ttctggaaaa atagagaaca aaaggaaaag attgttacca   3120

ccttgattta ataacttctt gtttccccat acatgtgttt tgtttataga ttgcatgggt   3180

atatgtcaat ttttatatgt tctgtgttta gtttacatat tgtaattcat ttttaagaga   3240

gtacagacat acactttttg agtaggcaat atgttcacat agtttgaaat taaaggtaca   3300

aaatggcgta gaatgaaatg cctctcaccc tttccccaca gcgactactt cccactcaga   3360

ggcaacaagt attacagttg cttgtatatt cttccagaga tctctgtcta tacaagcaaa   3420

aacacatgtg gtctttttcc ttgctttgca caaatggtaa actgtacgct attctgaacc   3480

ttgctttttt cagatatatg ttggcaacag ttccatgtca gtacatagtt tcctttcttt   3540

attacagctg cctgtttttt cattgtgtat ttgcaccatc atttactttt ctggcttact   3600

tttgatagaa atctaggttg gttcaaacct ttttactctt aaaacaatgc tgcagttaac   3660

acccttgtac atatatcttt agagagaaga tattttaaaa agaaatacct ttttaaaaat   3720

tattttatta ttttttaata gagactatgt tgcctaggct ggtcttgaaa ttctgggcta   3780

aagcaatcct accaccttgg cctcccaaag tgctgagatt acaggcatga gccattgcac   3840

ctggccaaga agagacatct tgacttgagc ctgaagacta tgtacagaga ctgacctcac   3900

agactgacca ttccatccca cagctgctgg acatagagtg atttgcagcc cctcctttca   3960

gagtaccaca tccctctcaa gtgttccaca acatctagga aagtgagctc ttaaagacag   4020

actaaaaaga gtaataaatc aatacaacaa cattaaaagc cagactagcg gagtttgaat   4080

cttggccctg ctgttagtaa ctgtgtgagc cttgggcaag ttactcagcc tccttgtgtc   4140

ttggttttgg tttcttcatc tctaagtaat tatatctgtc attattgccc tgatcacaaa   4200

caaaagcctg aatgtactat gtttaaaaga caaaccaaaa attaacccaa acttgcatta   4260

tttgtctgag ctacagaatg ttctttcctt ggagagatat ctgatattaa acatcatctg   4320

cattttactt gcctagaaaa tacacggtaa cttttctgcc ttgcagcatc aaactatagt   4380

acagctgagc cccagtgctg tgcagtctga ctctaattaa aggcaccttc tttacagcag   4440

ggctctgggg aactggaaaa gggggtttgt ttcattatct ggttttatta agcagatgaa   4500

tgcagccagc tatatgaagc actttgcagt gaatggcagg tgtcccatat ctggttatgt   4560

taacctagaa agggctcact ctacctctag gcatgtttca tcccaacaat cagactgtgc   4620

caaagcaggg gactttgtcc tttgtggatt gcatagctgg atacccatca tctgtttctc   4680

tgattggaag ctgctgttgt acagaaagac ctgcatttcc cccttgtctc cagttctctc   4740

actacttttt cctcctctgt gagtgaccat ccaggcagtc accataactg ctggagtgtc   4800

tgggattggt agctctctcc aactgcctgc ttgctcttta cagcctctct ctgtgactgg   4860

aatctctcca cctcatcgta tctaaggata acccagaaac atggggtgtc ctaggtatgt   4920

ttatctcgac actgaacccc ctaggcttct gatgaatcca gtgattagct aaatttgaca   4980

tagaaagtaa gaaggaatgt ctactttgta ttgtggtcct aatctaagat caggagaatc   5040

ctggaattgt tatctgtctc ttgctctgag atacagactt gttcataggt gtggggcctg   5100

attggaacag gatctgccat tggtcacaat aggtcaaggg cttgttctga accctagtta   5160

gcttcattca gagaaagaaa cttcctacct ggtcagcttt ttcagcttct ccaacaaatg   5220

ggagttgagg cagtaggagt gtggggttct tgggaagacg atggggcctt gtattaagga   5280

gaaataatga actatcttct tgattcttcc attgagaaaa gcatatgaat cctaggaaag   5340

ggctcagcct gtgataggca ttcaataaat actccaatgc tgtcattcct ttgtctacag   5400

catccccaaa caatgtacca gtgatgggct acctgagctc atctagtcgc caagcagtat   5460

ctcctgcttg ctgctgcttt actacattcc agatgcccac ctcatccaat ttccagagcc   5520

actatctctg ctgtccactt tccttcaggc tctgtgaata cttcaacctg ctgtgatttg   5580

gggccgtttg tactctgcat gtattcaata aattcaattc agcaatagtt              5630


<210>  2323
<211>  485
<212>  PRT
<213>  Homo sapiens

<400>  2323


Met Gly Glu Pro Gly Phe Phe Val Thr Gly Asp Arg Ala Gly Gly Arg 
1               5                   10                  15      


Ser Trp Cys Leu Arg Arg Val Gly Met Ser Ala Gly Trp Leu Leu Leu 
            20                  25                  30          


Glu Asp Gly Cys Glu Val Thr Val Gly Arg Gly Phe Gly Val Thr Tyr 
        35                  40                  45              


Gln Leu Val Ser Lys Ile Cys Pro Leu Met Ile Ser Arg Asn His Cys 
    50                  55                  60                  


Val Leu Lys Gln Asn Pro Glu Gly Gln Trp Thr Ile Met Asp Asn Lys 
65                  70                  75                  80  


Ser Leu Asn Gly Val Trp Leu Asn Arg Ala Arg Leu Glu Pro Leu Arg 
                85                  90                  95      


Val Tyr Ser Ile His Gln Gly Asp Tyr Ile Gln Leu Gly Val Pro Leu 
            100                 105                 110         


Glu Asn Lys Glu Asn Ala Glu Tyr Glu Tyr Glu Val Thr Glu Glu Asp 
        115                 120                 125             


Trp Glu Thr Ile Tyr Pro Cys Leu Ser Pro Lys Asn Asp Gln Met Ile 
    130                 135                 140                 


Glu Lys Asn Lys Glu Leu Arg Thr Lys Arg Lys Phe Ser Leu Asp Glu 
145                 150                 155                 160 


Leu Ala Gly Pro Gly Ala Glu Gly Pro Ser Asn Leu Lys Ser Lys Ile 
                165                 170                 175     


Asn Lys Val Ser Cys Glu Ser Gly Gln Pro Val Lys Ser Gln Gly Lys 
            180                 185                 190         


Gly Glu Val Ala Ser Thr Pro Ser Asp Asn Leu Asp Pro Lys Leu Thr 
        195                 200                 205             


Ala Leu Glu Pro Ser Lys Thr Thr Gly Ala Pro Ile Tyr Pro Gly Phe 
    210                 215                 220                 


Pro Lys Val Thr Glu Val His His Glu Gln Lys Ala Ser Asn Ser Ser 
225                 230                 235                 240 


Ala Ser Gln Arg Ser Leu Gln Met Phe Lys Val Thr Met Ser Arg Ile 
                245                 250                 255     


Leu Arg Leu Lys Ile Gln Met Gln Glu Lys His Glu Ala Val Met Asn 
            260                 265                 270         


Val Lys Lys Gln Thr Gln Lys Gly Asn Ser Lys Lys Val Val Gln Met 
        275                 280                 285             


Glu Gln Glu Leu Gln Asp Leu Gln Ser Gln Leu Cys Ala Glu Gln Ala 
    290                 295                 300                 


Gln Gln Gln Ala Arg Val Glu Gln Leu Glu Lys Thr Phe Gln Glu Glu 
305                 310                 315                 320 


Glu Gln His Leu Gln Gly Leu Glu Ile Ala Gln Gly Glu Lys Asp Leu 
                325                 330                 335     


Lys Gln Gln Leu Ala Gln Ala Leu Gln Glu His Trp Ala Leu Met Glu 
            340                 345                 350         


Glu Leu Asn Arg Ser Lys Lys Asp Phe Glu Ala Ile Ile Gln Ala Lys 
        355                 360                 365             


Asn Lys Glu Leu Glu Gln Thr Lys Glu Glu Lys Glu Lys Met Gln Ala 
    370                 375                 380                 


Gln Lys Glu Glu Val Leu Ser His Met Asn Asp Val Leu Glu Asn Glu 
385                 390                 395                 400 


Leu Gln Cys Ile Ile Cys Ser Glu Tyr Phe Ile Glu Ala Val Thr Leu 
                405                 410                 415     


Asn Cys Ala His Ser Phe Cys Ser Tyr Cys Ile Asn Glu Trp Met Lys 
            420                 425                 430         


Arg Lys Ile Glu Cys Pro Ile Cys Arg Lys Asp Ile Lys Ser Lys Thr 
        435                 440                 445             


Tyr Ser Leu Val Leu Asp Asn Cys Ile Asn Lys Met Val Asn Asn Leu 
    450                 455                 460                 


Ser Ser Glu Val Lys Glu Arg Arg Ile Val Leu Ile Arg Glu Arg Lys 
465                 470                 475                 480 


Ala Lys Arg Leu Phe 
                485 

<210>  2324
<211>  5833
<212>  DNA
<213>  Homo sapiens

<400>  2324
cttgcgcagg cgtagtgctc ctgcttcctg gccgagggcg ggcgagcgga gcctgctttc     60

gcagcgatcg cgagcgtgtg gcgattgctt ctgtctgtta tttagatatg gaagctgagg    120

ggatgcacag aggcagccag aacctaggtc agggtctcgc tcggtgctga ccgcccccgg    180

ggtcgagtag gcgatggggg agcccggctt cttcgtcaca ggagaccgcg ccggtggccg    240

gagctggtgc ctgcggcggg tggggatgag cgccgggtgg ctgctgctgg aagatgggtg    300

cgaggtgact gtaggacgag gatttggtgt cacataccaa ctggtatcaa aaatctgccc    360

cctgatgatt tctcgaaacc actgtgtttt gaagcagaat cctgagggcc aatggacaat    420

tatggacaac aagagtctaa atggtgtttg gctgaacaga gcgcgtctgg aacctttaag    480

ggtctattcc attcatcagg gagactacat ccaacttgga gtgcctctgg aaaataagga    540

gaatgcggag tatgaatatg aagttactga agaagactgg gagacaatat atccttgtct    600

ttccccaaag aatgaccaaa tgatagaaaa aaataaggaa ttgagaacta aaaggaaatt    660

cagtttggat gaattagcag gtcctggagc tgaaggcccc tcaaatttga aatccaaaat    720

aaataaagtg tcttgtgaat ctggtcagcc agtgaaatca caggggaaag gtgaagtggc    780

cagtacaccc tctgacaatt tggatcctaa gttgactgcc cttgagccaa gtaagaccac    840

aggggctccc atttaccctg gcttccccaa agtcacagag gttcatcatg agcagaaagc    900

ctcaaactct tcagcatctc agagaagctt acagatgttt aaggtgacca tgtccaggat    960

tctgaggctc aaaatacaga tgcaggaaaa acatgaagcc gttatgaatg tgaaaaagca   1020

gacccaaaag gggaactcaa agaaagttgt gcaaatggag caggaacttc aggacttaca   1080

gtcccagctg tgtgcagagc aggctcagca gcaggcaaga gtggagcaac tagagaagac   1140

tttccaggaa gaggaacagc atcttcaggg tttggagata gcccaaggag aaaaggacct   1200

gaagcaacag ctggcccagg ctctgcagga gcattgggct ctaatggaag agctaaatcg   1260

cagcaagaag gactttgaag caatcattca agccaagaac aaagaattag agcagaccaa   1320

ggaagagaag gagaagatgc aagcacagaa ggaagaagtt cttagccaca tgaatgatgt   1380

gctagagaat gagctccaat gtattatttg ttcagaatac ttcattgagg ctgtcacctt   1440

gaactgtgcc cacagtttct gctcctactg tatcaatgaa tggatgaagc ggaagataga   1500

atgccccatt tgtcggaagg acattaagtc caaaacgtac tctttggttc tggacaattg   1560

cattaataag atggtaaata atctgagctc agaagtgaaa gaacgacgaa ttgttctcat   1620

tagggaacga aaagcaaaga gattgttctg aagaccgtgc tctaagggca tttgaaagac   1680

tgccaggtag tgcgagcctg agatggtctg gaggattctc tctagccgtg actccgctgc   1740

tctgaaggtc aactgagaag tcttgtggga cagagacttg agttaggaag ccctcagtca   1800

cttgccttcc acggtggcca gccctgctgc catcattggc tgaagcacca ccaggattca   1860

cggcacccaa ctgcttcagg gtacttcgta gactctgcct cactacatgt cgaaagagtt   1920

atttgagttc tcttctgttt ttttttaatt tgttgttgtt gttactgttt tgatacctcg   1980

gaaacacctc cgttgacagt tgttttggat aggttgggtg taccccatgg ctgcctctga   2040

aggcagtgtc tattttgaga ggatggctta cctcttcttt gtgaaaatac tatctcattt   2100

cctggaaata aaatgtaaaa cctgtcagtt gctcagctgg gctttggtgt atttaccttc   2160

cttcccttcc tgctcccaga cagtctcaca agtaaacacc agcagctcat agattacaac   2220

caagaaagtg actgtatcag atgatagact tcaagtgaat gtcagcctaa gaggccaagc   2280

tgcagatcgt ggcaacagat gagctctgtt aacctcctga ctgtcgtgtt tcctttttat   2340

tacagaggtg ggtcactgtt taccttgttt caggggtggg agaaactcct ttccttcagc   2400

tggcatttga atgtttccaa atctatttta tctgacgtca tgaacacaca ggcaatgatt   2460

ttatgacaac ttgatgtgct tttttcttta tttttctttt acattagaag ttttctctct   2520

tttctccacc tctcctttat ttttaatttt aattttaatt tttgaaacaa gatctgactc   2580

tgttgcccaa gctggagtac agtagtgcaa tctcagctca ctgcaacctc cacctcccag   2640

actcaagcca tcctcccacc tcaacctccc aagtagctgg gactacaggc atatgccatc   2700

acacccagct aatttttgtt tttctgtaga gacagggttt caccatgttg gccaggctgg   2760

tctcaaattc ctgaccttaa gtgatccacc tgcctaggcc tctaaaatgc tgggattaca   2820

ggcgtgagcc accacgccca gcctataccc catgtatttt cataaagggt tggaaactat   2880

tgattgccaa ctttttaagg atggtaggga ttttttcttt gttgaatata ctgtgaattt   2940

tgggattctg gagtccttag tcttcatttc cattcttctg cccatgatta ctgatcaaaa   3000

tactggtaga gtcatggagg aagtaagtta aatgtggaaa aaatgcttta aaagtactta   3060

ctataaccac atcataagaa ttctggaaaa atagagaaca aaaggaaaag attgttacca   3120

ccttgattta ataacttctt gtttccccat acatgtgttt tgtttataga ttgcatgggt   3180

atatgtcaat ttttatatgt tctgtgttta gtttacatat tgtaattcat ttttaagaga   3240

gtacagacat acactttttg agtaggcaat atgttcacat agtttgaaat taaaggtaca   3300

aaatggcgta gaatgaaatg cctctcaccc tttccccaca gcgactactt cccactcaga   3360

ggcaacaagt attacagttg cttgtatatt cttccagaga tctctgtcta tacaagcaaa   3420

aacacatgtg gtctttttcc ttgctttgca caaatggtaa actgtacgct attctgaacc   3480

ttgctttttt cagatatatg ttggcaacag ttccatgtca gtacatagtt tcctttcttt   3540

attacagctg cctgtttttt cattgtgtat ttgcaccatc atttactttt ctggcttact   3600

tttgatagaa atctaggttg gttcaaacct ttttactctt aaaacaatgc tgcagttaac   3660

acccttgtac atatatcttt agagagaaga tattttaaaa agaaatacct ttttaaaaat   3720

tattttatta ttttttaata gagactatgt tgcctaggct ggtcttgaaa ttctgggcta   3780

aagcaatcct accaccttgg cctcccaaag tgctgagatt acaggcatga gccattgcac   3840

ctggccaaga agagacatct tgacttgagc ctgaagacta tgtacagaga ctgacctcac   3900

agactgacca ttccatccca cagctgctgg acatagagtg atttgcagcc cctcctttca   3960

gagtaccaca tccctctcaa gtgttccaca acatctagga aagtgagctc ttaaagacag   4020

actaaaaaga gtaataaatc aatacaacaa cattaaaagc cagactagcg gagtttgaat   4080

cttggccctg ctgttagtaa ctgtgtgagc cttgggcaag ttactcagcc tccttgtgtc   4140

ttggttttgg tttcttcatc tctaagtaat tatatctgtc attattgccc tgatcacaaa   4200

caaaagcctg aatgtactat gtttaaaaga caaaccaaaa attaacccaa acttgcatta   4260

tttgtctgag ctacagaatg ttctttcctt ggagagatat ctgatattaa acatcatctg   4320

cattttactt gcctagaaaa tacacggtaa cttttctgcc ttgcagcatc aaactatagt   4380

acagctgagc cccagtgctg tgcagtctga ctctaattaa aggcaccttc tttacagcag   4440

ggctctgggg aactggaaaa gggggtttgt ttcattatct ggttttatta agcagatgaa   4500

tgcagccagc tatatgaagc actttgcagt gaatggcagg tgtcccatat ctggttatgt   4560

taacctagaa agggctcact ctacctctag gcatgtttca tcccaacaat cagactgtgc   4620

caaagcaggg gactttgtcc tttgtggatt gcatagctgg atacccatca tctgtttctc   4680

tgattggaag ctgctgttgt acagaaagac ctgcatttcc cccttgtctc cagttctctc   4740

actacttttt cctcctctgt gagtgaccat ccaggcagtc accataactg ctggagtgtc   4800

tgggattggt agctctctcc aactgcctgc ttgctcttta cagcctctct ctgtgactgg   4860

aatctctcca cctcatcgta tctaaggata acccagaaac atggggtgtc ctaggtatgt   4920

ttatctcgac actgaacccc ctaggcttct gatgaatcca gtgattagct aaatttgaca   4980

tagaaagtaa gaaggaatgt ctactttgta ttgtggtcct aatctaagat caggagaatc   5040

ctggaattgt tatctgtctc ttgctctgag atacagactt gttcataggt gtggggcctg   5100

attggaacag gatctgccat tggtcacaat aggtcaaggg cttgttctga accctagtta   5160

gcttcattca gagaaagaaa cttcctacct ggtcagcttt ttcagcttct ccaacaaatg   5220

ggagttgagg cagtaggagt gtggggttct tgggaagacg atggggcctt gtattaagga   5280

gaaataatga actatcttct tgattcttcc attgagaaaa gcatatgaat cctaggaaag   5340

ggctcagcct gtgataggca ttcaataaat actccaatgc tgtcattcct ttgtctacag   5400

catccccaaa caatgtacca gtgatgggct acctgagctc atctagtcgc caagcagtat   5460

ctcctgcttg ctgctgcttt actacattcc agatgcccac ctcatccaat ttccagagcc   5520

actatctctg ctgtccactt tccttcaggc tctgtgaata cttcaacctg ctgtgatttg   5580

gggccgtttg tactctgcat gtattcaata aattcaattc agcaatagtt atcaaatgcc   5640

cattttctta ctaggcactg ctctaggtgt ttggtatggc aatgagcaaa acacaaccat   5700

tgtgagctga tgttctagaa aggtgtcaaa agcgtttcaa aggttttatg agatgctgtg   5760

ggagggggtt acgcactgct acctactgag gtagcaatgt tgggtgtttc ctcacattcc   5820

tcaacctcca cgc                                                      5833


<210>  2325
<211>  485
<212>  PRT
<213>  Homo sapiens

<400>  2325


Met Gly Glu Pro Gly Phe Phe Val Thr Gly Asp Arg Ala Gly Gly Arg 
1               5                   10                  15      


Ser Trp Cys Leu Arg Arg Val Gly Met Ser Ala Gly Trp Leu Leu Leu 
            20                  25                  30          


Glu Asp Gly Cys Glu Val Thr Val Gly Arg Gly Phe Gly Val Thr Tyr 
        35                  40                  45              


Gln Leu Val Ser Lys Ile Cys Pro Leu Met Ile Ser Arg Asn His Cys 
    50                  55                  60                  


Val Leu Lys Gln Asn Pro Glu Gly Gln Trp Thr Ile Met Asp Asn Lys 
65                  70                  75                  80  


Ser Leu Asn Gly Val Trp Leu Asn Arg Ala Arg Leu Glu Pro Leu Arg 
                85                  90                  95      


Val Tyr Ser Ile His Gln Gly Asp Tyr Ile Gln Leu Gly Val Pro Leu 
            100                 105                 110         


Glu Asn Lys Glu Asn Ala Glu Tyr Glu Tyr Glu Val Thr Glu Glu Asp 
        115                 120                 125             


Trp Glu Thr Ile Tyr Pro Cys Leu Ser Pro Lys Asn Asp Gln Met Ile 
    130                 135                 140                 


Glu Lys Asn Lys Glu Leu Arg Thr Lys Arg Lys Phe Ser Leu Asp Glu 
145                 150                 155                 160 


Leu Ala Gly Pro Gly Ala Glu Gly Pro Ser Asn Leu Lys Ser Lys Ile 
                165                 170                 175     


Asn Lys Val Ser Cys Glu Ser Gly Gln Pro Val Lys Ser Gln Gly Lys 
            180                 185                 190         


Gly Glu Val Ala Ser Thr Pro Ser Asp Asn Leu Asp Pro Lys Leu Thr 
        195                 200                 205             


Ala Leu Glu Pro Ser Lys Thr Thr Gly Ala Pro Ile Tyr Pro Gly Phe 
    210                 215                 220                 


Pro Lys Val Thr Glu Val His His Glu Gln Lys Ala Ser Asn Ser Ser 
225                 230                 235                 240 


Ala Ser Gln Arg Ser Leu Gln Met Phe Lys Val Thr Met Ser Arg Ile 
                245                 250                 255     


Leu Arg Leu Lys Ile Gln Met Gln Glu Lys His Glu Ala Val Met Asn 
            260                 265                 270         


Val Lys Lys Gln Thr Gln Lys Gly Asn Ser Lys Lys Val Val Gln Met 
        275                 280                 285             


Glu Gln Glu Leu Gln Asp Leu Gln Ser Gln Leu Cys Ala Glu Gln Ala 
    290                 295                 300                 


Gln Gln Gln Ala Arg Val Glu Gln Leu Glu Lys Thr Phe Gln Glu Glu 
305                 310                 315                 320 


Glu Gln His Leu Gln Gly Leu Glu Ile Ala Gln Gly Glu Lys Asp Leu 
                325                 330                 335     


Lys Gln Gln Leu Ala Gln Ala Leu Gln Glu His Trp Ala Leu Met Glu 
            340                 345                 350         


Glu Leu Asn Arg Ser Lys Lys Asp Phe Glu Ala Ile Ile Gln Ala Lys 
        355                 360                 365             


Asn Lys Glu Leu Glu Gln Thr Lys Glu Glu Lys Glu Lys Met Gln Ala 
    370                 375                 380                 


Gln Lys Glu Glu Val Leu Ser His Met Asn Asp Val Leu Glu Asn Glu 
385                 390                 395                 400 


Leu Gln Cys Ile Ile Cys Ser Glu Tyr Phe Ile Glu Ala Val Thr Leu 
                405                 410                 415     


Asn Cys Ala His Ser Phe Cys Ser Tyr Cys Ile Asn Glu Trp Met Lys 
            420                 425                 430         


Arg Lys Ile Glu Cys Pro Ile Cys Arg Lys Asp Ile Lys Ser Lys Thr 
        435                 440                 445             


Tyr Ser Leu Val Leu Asp Asn Cys Ile Asn Lys Met Val Asn Asn Leu 
    450                 455                 460                 


Ser Ser Glu Val Lys Glu Arg Arg Ile Val Leu Ile Arg Glu Arg Lys 
465                 470                 475                 480 


Ala Lys Arg Leu Phe 
                485 

<210>  2326
<211>  698
<212>  DNA
<213>  Homo sapiens

<400>  2326
gtagtgctcc tgcttcctgg ccgagggcgg gcgagcggag cctgctttcg cagcgatcgc     60

gagcgtgtgg cgattgcttc tgtctgttat ttagatatgg aagctgaggg gatgcacaga    120

ggcagccaga acctaggtca gggtctcgct cggtgctgac cgcccccggg gtcgagtagg    180

cgatggggga gcccggcttc ttcgtcacag gagaccgcgc cggtggccgg agctggtgcc    240

tgcggcgggt ggggatgagc gccgggtggc tgctgctgga agatgggtgc gaggtgactg    300

taggacgagg atttggtgtc acataccaac tggtatcaaa aatctgcccc ctgatgattt    360

ctcgaaacca ctgtgttttg aagcagaatc ctgagggcca atggacaatt atggacaaca    420

aggggaccac cagtttgtct aaggagaggt gaactgaccc aggttggaag gagggcaggt    480

caaaactgct gtgctcatca acaaagggat tgcacctgtg aatagccact gcactccagt    540

gtggctgaca tagtgaagcc ctgtcgctat caaaaagaaa agaagatacc taaagtgcag    600

atatacaagc accgaggaat gtgatgaaaa tacagactat gagagtctaa atggtgtttg    660

gctgaacaga gcgcgtctgg aacctttaag ggtctatt                            698


<210>  2327
<211>  89
<212>  PRT
<213>  Homo sapiens

<400>  2327


Met Gly Glu Pro Gly Phe Phe Val Thr Gly Asp Arg Ala Gly Gly Arg 
1               5                   10                  15      


Ser Trp Cys Leu Arg Arg Val Gly Met Ser Ala Gly Trp Leu Leu Leu 
            20                  25                  30          


Glu Asp Gly Cys Glu Val Thr Val Gly Arg Gly Phe Gly Val Thr Tyr 
        35                  40                  45              


Gln Leu Val Ser Lys Ile Cys Pro Leu Met Ile Ser Arg Asn His Cys 
    50                  55                  60                  


Val Leu Lys Gln Asn Pro Glu Gly Gln Trp Thr Ile Met Asp Asn Lys 
65                  70                  75                  80  


Gly Thr Thr Ser Leu Ser Lys Glu Arg 
                85                  

<210>  2328
<211>  3091
<212>  DNA
<213>  Homo sapiens

<400>  2328
gctaacccgc ttgcagactg agaaatgaaa agtttggaac ccagaagctg cagcctgcgg     60

aaaatgctgg agccgcagcc gacaccaagt tgatgtctgt gagcagctga ccttctggac    120

ctccatcagc ggcctgcagc caggagctga agccacagag acggtgtctt ctcagctatg    180

ataacctcag tgcaaatatt gcccaatcac tgaagagctg tgatcttcct aaacagttaa    240

aagtcaggca cagctatgta actcatacag tttctctttg ccagactaga ctaaagaagg    300

agcactaatt tattctgata aaacaggtct atgcagctac caggacaatg gaatctacgt    360

tgactttagc aacggaacaa cctgttaaga agaacactct taagaaatat aaaatagctt    420

gcattgttct tcttgctttg ctggtgatca tgtcacttgg attaggcctg gggcttggac    480

tcaggaaact ggaaaagcaa ggcagctgca ggaagaagtg ctttgatgca tcatttagag    540

gactggagaa ctgccggtgt gatgtggcat gtaaagaccg aggtgattgc tgctgggatt    600

ttgaagacac ctgtgtggaa tcaactcgaa tatggatgtg caataaattt cgttgtggag    660

agaccagatt agaggccagc ctttgctctt gttcagatga ctgtttgcag aggaaagatt    720

gctgtgctga ctataagagt gtttgccaag gagaaacctc atggctggaa gaaaactgtg    780

acacagccca gcagtctcag tgcccagaag ggtttgacct gccaccagtt atcttgtttt    840

ctatggatgg atttagagct gaatatttat acacatggga tactttaatg ccaaatatca    900

ataaactgaa aacatgtgga attcattcaa aatacatgag agctatgtat cctaccaaaa    960

ccttcccaaa tcattacacc attgtcacgg gcttgtatcc agagtcacat ggcatcattg   1020

acaataatat gtatgatgta aatctcaaca agaatttttc actttcttca aaggaacaaa   1080

ataatccagc ctggtggcat gggcaaccaa tgtggctgac agcaatgtat caaggtttaa   1140

aagccgctac ctacttttgg cccggatcag aagtggctat aaatggctcc tttccttcca   1200

tatacatgcc ttacaacgga agtgtcccat ttgaagagag gatttctaca ctgttaaaat   1260

ggctggacct gcccaaagct gaaagaccca ggttttatac catgtatttt gaagaacctg   1320

attcctctgg acatgcaggt ggaccagtca gtgccagagt aattaaagcc ttacaggtag   1380

tagatcatgc ttttgggatg ttgatggaag gcctgaagca gcggaatttg cacaactgtg   1440

tcaatatcat ccttctggct gaccatggaa tggaccagac ttattgtaac aagatggaat   1500

acatgactga ttattttccc agaataaact tcttctacat gtacgaaggg cctgcccccc   1560

gcatccgagc tcataatata cctcatgact tttttagttt taattctgag gaaattgtta   1620

gaaacctcag ttgccgaaaa cctgatcagc atttcaagcc ctatttgact cctgatttgc   1680

caaagcgact gcactatgcc aagaacgtca gaatcgacaa agttcatctc tttgtggatc   1740

aacagtggct ggctgttagg agtaaatcaa atacaaattg tggaggaggc aaccatggtt   1800

ataacaatga gtttaggagc atggaggcta tctttctggc acatggaccc agttttaaag   1860

agaagactga agttgaacca tttgaaaata ttgaagtcta taacctaatg tgtgatcttc   1920

tacgcattca accagcacca aacaatggaa cccatggtag tttaaaccat cttctgaagg   1980

tgccttttta tgagccatcc catgcagagg aggtgtcaaa gttttctgtt tgtggctttg   2040

ctaatccatt gcccacagag tctcttgact gtttctgccc tcacctacaa aatagtactc   2100

agctggaaca agtgaatcag atgctaaatc tcacccaaga agaaataaca gcaacagtga   2160

aagtaaattt gccatttggg aggcctaggg tactgcagaa gaacgtggac cactgtctcc   2220

tttaccacag ggaatatgtc agtggatttg gaaaagctat gaggatgccc atgtggagtt   2280

catacacagt cccccagttg ggagacacat cgcctctgcc tcccactgtc ccagactgtc   2340

tgcgggctga tgtcagggtt cctccttctg agagccaaaa atgttccttc tatttagcag   2400

acaagaatat cacccacggc ttcctctatc ctcctgccag caatagaaca tcagatagcc   2460

aatatgatgc tttaattact agcaatttgg tacctatgta tgaagaattc agaaaaatgt   2520

gggactactt ccacagtgtt cttcttataa aacatgccac agaaagaaat ggagtaaatg   2580

tggttagtgg accaatattt gattataatt atgatggcca ttttgatgct ccagatgaaa   2640

ttaccaaaca tttagccaac actgatgttc ccatcccaac acactacttt gtggtgctga   2700

ccagttgtaa aaacaagagc cacacaccgg aaaactgccc tgggtggctg gatgtcctac   2760

cctttatcat ccctcaccga cctaccaacg tggagagctg tcctgaaggt aaaccagaag   2820

ctctttgggt tgaagaaaga tttacagctc acattgcccg ggtccgtgat gtagaacttc   2880

tcactgggct tgacttctat caggataaag tgcagcctgt ctctgaaatt ttgcaactaa   2940

agacatattt accaacattt gaaaccacta tttaacttaa taatgtctac ttaatatata   3000

atttactgta taaagtaatt ttggcaaaat ataagtgatt tttttctgga gaattgtaaa   3060

ataaagtttt ctatttttcc ttaagtcccc t                                  3091


<210>  2329
<211>  875
<212>  PRT
<213>  Homo sapiens

<400>  2329


Met Glu Ser Thr Leu Thr Leu Ala Thr Glu Gln Pro Val Lys Lys Asn 
1               5                   10                  15      


Thr Leu Lys Lys Tyr Lys Ile Ala Cys Ile Val Leu Leu Ala Leu Leu 
            20                  25                  30          


Val Ile Met Ser Leu Gly Leu Gly Leu Gly Leu Gly Leu Arg Lys Leu 
        35                  40                  45              


Glu Lys Gln Gly Ser Cys Arg Lys Lys Cys Phe Asp Ala Ser Phe Arg 
    50                  55                  60                  


Gly Leu Glu Asn Cys Arg Cys Asp Val Ala Cys Lys Asp Arg Gly Asp 
65                  70                  75                  80  


Cys Cys Trp Asp Phe Glu Asp Thr Cys Val Glu Ser Thr Arg Ile Trp 
                85                  90                  95      


Met Cys Asn Lys Phe Arg Cys Gly Glu Thr Arg Leu Glu Ala Ser Leu 
            100                 105                 110         


Cys Ser Cys Ser Asp Asp Cys Leu Gln Arg Lys Asp Cys Cys Ala Asp 
        115                 120                 125             


Tyr Lys Ser Val Cys Gln Gly Glu Thr Ser Trp Leu Glu Glu Asn Cys 
    130                 135                 140                 


Asp Thr Ala Gln Gln Ser Gln Cys Pro Glu Gly Phe Asp Leu Pro Pro 
145                 150                 155                 160 


Val Ile Leu Phe Ser Met Asp Gly Phe Arg Ala Glu Tyr Leu Tyr Thr 
                165                 170                 175     


Trp Asp Thr Leu Met Pro Asn Ile Asn Lys Leu Lys Thr Cys Gly Ile 
            180                 185                 190         


His Ser Lys Tyr Met Arg Ala Met Tyr Pro Thr Lys Thr Phe Pro Asn 
        195                 200                 205             


His Tyr Thr Ile Val Thr Gly Leu Tyr Pro Glu Ser His Gly Ile Ile 
    210                 215                 220                 


Asp Asn Asn Met Tyr Asp Val Asn Leu Asn Lys Asn Phe Ser Leu Ser 
225                 230                 235                 240 


Ser Lys Glu Gln Asn Asn Pro Ala Trp Trp His Gly Gln Pro Met Trp 
                245                 250                 255     


Leu Thr Ala Met Tyr Gln Gly Leu Lys Ala Ala Thr Tyr Phe Trp Pro 
            260                 265                 270         


Gly Ser Glu Val Ala Ile Asn Gly Ser Phe Pro Ser Ile Tyr Met Pro 
        275                 280                 285             


Tyr Asn Gly Ser Val Pro Phe Glu Glu Arg Ile Ser Thr Leu Leu Lys 
    290                 295                 300                 


Trp Leu Asp Leu Pro Lys Ala Glu Arg Pro Arg Phe Tyr Thr Met Tyr 
305                 310                 315                 320 


Phe Glu Glu Pro Asp Ser Ser Gly His Ala Gly Gly Pro Val Ser Ala 
                325                 330                 335     


Arg Val Ile Lys Ala Leu Gln Val Val Asp His Ala Phe Gly Met Leu 
            340                 345                 350         


Met Glu Gly Leu Lys Gln Arg Asn Leu His Asn Cys Val Asn Ile Ile 
        355                 360                 365             


Leu Leu Ala Asp His Gly Met Asp Gln Thr Tyr Cys Asn Lys Met Glu 
    370                 375                 380                 


Tyr Met Thr Asp Tyr Phe Pro Arg Ile Asn Phe Phe Tyr Met Tyr Glu 
385                 390                 395                 400 


Gly Pro Ala Pro Arg Ile Arg Ala His Asn Ile Pro His Asp Phe Phe 
                405                 410                 415     


Ser Phe Asn Ser Glu Glu Ile Val Arg Asn Leu Ser Cys Arg Lys Pro 
            420                 425                 430         


Asp Gln His Phe Lys Pro Tyr Leu Thr Pro Asp Leu Pro Lys Arg Leu 
        435                 440                 445             


His Tyr Ala Lys Asn Val Arg Ile Asp Lys Val His Leu Phe Val Asp 
    450                 455                 460                 


Gln Gln Trp Leu Ala Val Arg Ser Lys Ser Asn Thr Asn Cys Gly Gly 
465                 470                 475                 480 


Gly Asn His Gly Tyr Asn Asn Glu Phe Arg Ser Met Glu Ala Ile Phe 
                485                 490                 495     


Leu Ala His Gly Pro Ser Phe Lys Glu Lys Thr Glu Val Glu Pro Phe 
            500                 505                 510         


Glu Asn Ile Glu Val Tyr Asn Leu Met Cys Asp Leu Leu Arg Ile Gln 
        515                 520                 525             


Pro Ala Pro Asn Asn Gly Thr His Gly Ser Leu Asn His Leu Leu Lys 
    530                 535                 540                 


Val Pro Phe Tyr Glu Pro Ser His Ala Glu Glu Val Ser Lys Phe Ser 
545                 550                 555                 560 


Val Cys Gly Phe Ala Asn Pro Leu Pro Thr Glu Ser Leu Asp Cys Phe 
                565                 570                 575     


Cys Pro His Leu Gln Asn Ser Thr Gln Leu Glu Gln Val Asn Gln Met 
            580                 585                 590         


Leu Asn Leu Thr Gln Glu Glu Ile Thr Ala Thr Val Lys Val Asn Leu 
        595                 600                 605             


Pro Phe Gly Arg Pro Arg Val Leu Gln Lys Asn Val Asp His Cys Leu 
    610                 615                 620                 


Leu Tyr His Arg Glu Tyr Val Ser Gly Phe Gly Lys Ala Met Arg Met 
625                 630                 635                 640 


Pro Met Trp Ser Ser Tyr Thr Val Pro Gln Leu Gly Asp Thr Ser Pro 
                645                 650                 655     


Leu Pro Pro Thr Val Pro Asp Cys Leu Arg Ala Asp Val Arg Val Pro 
            660                 665                 670         


Pro Ser Glu Ser Gln Lys Cys Ser Phe Tyr Leu Ala Asp Lys Asn Ile 
        675                 680                 685             


Thr His Gly Phe Leu Tyr Pro Pro Ala Ser Asn Arg Thr Ser Asp Ser 
    690                 695                 700                 


Gln Tyr Asp Ala Leu Ile Thr Ser Asn Leu Val Pro Met Tyr Glu Glu 
705                 710                 715                 720 


Phe Arg Lys Met Trp Asp Tyr Phe His Ser Val Leu Leu Ile Lys His 
                725                 730                 735     


Ala Thr Glu Arg Asn Gly Val Asn Val Val Ser Gly Pro Ile Phe Asp 
            740                 745                 750         


Tyr Asn Tyr Asp Gly His Phe Asp Ala Pro Asp Glu Ile Thr Lys His 
        755                 760                 765             


Leu Ala Asn Thr Asp Val Pro Ile Pro Thr His Tyr Phe Val Val Leu 
    770                 775                 780                 


Thr Ser Cys Lys Asn Lys Ser His Thr Pro Glu Asn Cys Pro Gly Trp 
785                 790                 795                 800 


Leu Asp Val Leu Pro Phe Ile Ile Pro His Arg Pro Thr Asn Val Glu 
                805                 810                 815     


Ser Cys Pro Glu Gly Lys Pro Glu Ala Leu Trp Val Glu Glu Arg Phe 
            820                 825                 830         


Thr Ala His Ile Ala Arg Val Arg Asp Val Glu Leu Leu Thr Gly Leu 
        835                 840                 845             


Asp Phe Tyr Gln Asp Lys Val Gln Pro Val Ser Glu Ile Leu Gln Leu 
    850                 855                 860                 


Lys Thr Tyr Leu Pro Thr Phe Glu Thr Thr Ile 
865                 870                 875 

<210>  2330
<211>  1762
<212>  DNA
<213>  Homo sapiens

<400>  2330
ggatatggga gacaatataa catccatcag agagttcctc ctactgggat ttcccgttgg     60

cccaaggatt cagatgctcc tctttgggct cttctccctg ttctacgtct tcaccctgct    120

ggggaacggg accatactgg ggctcatctc actggactcc agactgcacg cccccatgta    180

cttcttcctc tcacacctgg cggtcgtcga catcgcctac gcctgcaaca cggtgccccg    240

gatgctggtg aacctcctgc atccagccaa gcccatctcc tttgcgggcc gcatgatgca    300

gacctttctg ttttccactt ttgctgtcac agaatgtctc ctcctggtgg tgatgtccta    360

tgatctgtac gtggccatct gccaccccct ccgatatttg gccatcatga cctggagagt    420

ctgcatcacc ctcgcggtga cttcctggac cactggagtc cttttatcct tgattcatct    480

tgtgttactt ctacctttac ccttctgtag gccccagaaa atttatcact ttttttgtga    540

aatcttggct gttctcaaac ttgcctgtgc agatacccac atcaatgaga acatggtctt    600

ggccggagca atttctgggc tggtgggacc cttgtccaca attgtagttt catatatgtg    660

catcctctgt gctatccttc agatccaatc aagggaagtt cagaggaaag ccttccgcac    720

ctgcttctcc cacctctgtg tgattggact cgtttatggc acagccatta tcatgtatgt    780

tggacccaga tatgggaacc ccaaggagca gaagaaatat ctcctgctgt ttcacagcct    840

ctttaatccc atgctcaatc cccttatctg tagtcttagg aactcagaag tgaagaatac    900

tttgaagaga gtgctgggag tagaaagggc tttatgaaaa ggattatggc attgtgactg    960

acagtgacct aggaagttac atcattgagc ggttcttaac ccatctctgc actggtggga   1020

cctctgccct caatggacat gagaattatc tgagacattt atttaaaatg gagctatctc   1080

ctgccctacc tttaaatgac tgatttcagc agatgtggga tgaaattcta gaaattgatc   1140

tcttcaagtt gtgctgcagc cactccacac caggacaata ccccttacaa tatcctcatt   1200

agcttttgat ccagtcccat acctcccata atgttttcct caaaacactg gtcccttcag   1260

aggactttaa aaataagttc tatagtcaaa taagtttgag acttacttca catcagatgc   1320

ctctgtctag ggatcacaat tcatattagc atagtgaatg ctgtaaatat ttctctagga   1380

aagaataatt ctataccagc tttaagccag tgttttctaa acttatgtga gcacataaaa   1440

tttcctttgt aatacttagt aacagtttcc tggaacagga gatcttgata ttaattgact   1500

cattgtgaat acttcctaca gcccccttct agggcagaat gatttctttt ttccttgcaa   1560

agtgagcctc taaagagatg tagttctgag cattatgcct cgatcagtct gtaaaaatcc   1620

gggttctgtt tggatacaga ccgtgaggga ccctgtctct actgttcaat ggtagatcat   1680

ctaaagaaaa taaatgcaat cctgtccttc atcatggatc ggcattcctg ctatagaagc   1740

ttcaggagat gacctcattc aa                                            1762


<210>  2331
<211>  310
<212>  PRT
<213>  Homo sapiens

<400>  2331


Met Gly Asp Asn Ile Thr Ser Ile Arg Glu Phe Leu Leu Leu Gly Phe 
1               5                   10                  15      


Pro Val Gly Pro Arg Ile Gln Met Leu Leu Phe Gly Leu Phe Ser Leu 
            20                  25                  30          


Phe Tyr Val Phe Thr Leu Leu Gly Asn Gly Thr Ile Leu Gly Leu Ile 
        35                  40                  45              


Ser Leu Asp Ser Arg Leu His Ala Pro Met Tyr Phe Phe Leu Ser His 
    50                  55                  60                  


Leu Ala Val Val Asp Ile Ala Tyr Ala Cys Asn Thr Val Pro Arg Met 
65                  70                  75                  80  


Leu Val Asn Leu Leu His Pro Ala Lys Pro Ile Ser Phe Ala Gly Arg 
                85                  90                  95      


Met Met Gln Thr Phe Leu Phe Ser Thr Phe Ala Val Thr Glu Cys Leu 
            100                 105                 110         


Leu Leu Val Val Met Ser Tyr Asp Leu Tyr Val Ala Ile Cys His Pro 
        115                 120                 125             


Leu Arg Tyr Leu Ala Ile Met Thr Trp Arg Val Cys Ile Thr Leu Ala 
    130                 135                 140                 


Val Thr Ser Trp Thr Thr Gly Val Leu Leu Ser Leu Ile His Leu Val 
145                 150                 155                 160 


Leu Leu Leu Pro Leu Pro Phe Cys Arg Pro Gln Lys Ile Tyr His Phe 
                165                 170                 175     


Phe Cys Glu Ile Leu Ala Val Leu Lys Leu Ala Cys Ala Asp Thr His 
            180                 185                 190         


Ile Asn Glu Asn Met Val Leu Ala Gly Ala Ile Ser Gly Leu Val Gly 
        195                 200                 205             


Pro Leu Ser Thr Ile Val Val Ser Tyr Met Cys Ile Leu Cys Ala Ile 
    210                 215                 220                 


Leu Gln Ile Gln Ser Arg Glu Val Gln Arg Lys Ala Phe Arg Thr Cys 
225                 230                 235                 240 


Phe Ser His Leu Cys Val Ile Gly Leu Val Tyr Gly Thr Ala Ile Ile 
                245                 250                 255     


Met Tyr Val Gly Pro Arg Tyr Gly Asn Pro Lys Glu Gln Lys Lys Tyr 
            260                 265                 270         


Leu Leu Leu Phe His Ser Leu Phe Asn Pro Met Leu Asn Pro Leu Ile 
        275                 280                 285             


Cys Ser Leu Arg Asn Ser Glu Val Lys Asn Thr Leu Lys Arg Val Leu 
    290                 295                 300                 


Gly Val Glu Arg Ala Leu 
305                 310 

<210>  2332
<211>  4577
<212>  DNA
<213>  Homo sapiens

<400>  2332
aataaatcag ttattaaaaa caaactcata gataatccag atattggagt taacagatag     60

ggcatcataa catctatggt gaatataaag gaaagaaaga aaaaatgaaa gacaaaacag    120

gttgtgtcag atttctttct ggaagcttta aaatgctcac tttattttca tagattctaa    180

tttcctaaat tatgtttgat gtttcaagca aaaatcatag cattgtctag tgttattcta    240

aatggatgta agaccattat actacaaatt tgatagagta aagagacata atatgacaga    300

aggttgctat acttcactca gactggaata aagatgatac caattgactg tgataatgtt    360

tatataaatg aatatacact aagctgtaaa atgcaaccac taagctataa aatgcaacca    420

aaaaaactat aaaaaagaag atacactata aacactataa ataacaaaat ggaattctaa    480

aacaaatgtt caagtaaccc acatgaagtc atgaaaaata agcagagaaa caagaattga    540

tagagaaaac aaaaaatgtc aggcttacgc attaaagtat caataattca tttaattatg    600

aatggtctac caagagatag ataatagaag agtgtattta aaagtatgac cctttcttat    660

atgtttcttg tatgctgtgt acaagaaact cacttgaatt ttaccaatac agggcaggcc    720

aaattaacag gatgaaaaaa gatatattac acaaacatta atgaaaggaa agcaagagtg    780

tctgtatgca tatcagataa agcaaagaaa actaccaaaa ccagagatta tgtaatgatc    840

aaaggtttaa tccatgaaga agacagcaat tttaaaagtg tattcaccaa aaaataaagc    900

ttcaaaatat gtgatgtgaa aactgccaga actaaggcgg gccgggctca gaccagcgct    960

gcctcaggat gtaaagtgta acaagagggc caggggaggt ggtgggggac aacatgggcc   1020

tgtgaggcct gtgggtgccc gcgttcccca gctccccccg cagcccgctc cacagtggtc   1080

cgctccggtt ggttgtcacg tgcgcattcg ggttccagac ccaaggctgc gtgttctcca   1140

ccgcttgttg tggccagtgt tactgcggtg accgccagag cagcctcgac gctatggagg   1200

agcctggtgc tacccctcag ccctacctgg ggctggtcct ggaggagcta ggcagagttg   1260

tggcagcact acctgagagt atgagaccag atgagaatcc ttatggtttt ccatcggaac   1320

tggtggtatg tgcagctgtt attggatttt ttgttgttct cctttttttg tggagaagtt   1380

ttagatcggt taggagtcgg ctttatgtgg gaagagagca aaaacttggt gcaacgcttt   1440

ctggactaat tgaagaaaaa tgtaaactac ttgaaaagtt tagccttatt caaaaagagt   1500

atgaaggcta tgaagtagag tcatctttag aggatgccag ctttgagaag gcggcagcag   1560

aagaagcacg aagtttggag gcaacctgtg aaaagctgag caggtccaat tctgaacttg   1620

aggatgaaat cctctgtcta gaaaaagact taaaagaaga gaaatctaaa cattctcaac   1680

aagatgaatt gatggcggat atttcaaaaa gtatacagtc tctagaagat gagtcaaaat   1740

ccctcaaatc acaaatagct gaagccaaaa tcatctgcaa gacatttaaa atgagtgaag   1800

aacgacgggc tatagcaata aaagatgctt tgaatgaaaa ttctcaactt cagacaagcc   1860

ataaacagct ttttcagcaa gaagctgaag tatggaaagg acaagtgagt gaacttaata   1920

aacagaaaat aacatttgaa gactccaaag tacacgcaga acaagttctg aatgataaag   1980

aaaatcacat caagaccctg actggacact tgccaatgat gaaagatcag gctgctgtgc   2040

ttgaagaaga cacaacggat gatgataacc tggaattaaa agtgaacagt caatgggaaa   2100

atggtgctaa cttagatgat cctccgaaag gagctttgaa gaaactgatt catgctgcta   2160

agttaaatgt ttctttaaaa agcttagaag gagaaagaaa ccacattatt attcagttat   2220

ctgaagtgga caaaacaaag gaagagctta cagagcatat taaaaatctt cagactcaac   2280

aagcatcttt gcaatcagaa aacatatatt ttgaaagtga gaatcagaag cttcaacaga   2340

aacttaaaat aatgactgaa ttctatcaag aaaatgaaat gaaactctac aggaaattaa   2400

cagtggagga aaattaccga atagaggaag aagagaagct ttctagagtg gaagaaaaga   2460

tcagccatgc cactgaagag ctggagacct atagaaagct agccaaagat cttgaagaag   2520

aattggagag aactgttcat ttttatcaaa agcaggttat ttcctacgag aaaagaggac   2580

atgataattg gttggcagct cggactgctg aaagaaacct cagtgattta aggaaagaaa   2640

atgctcacaa caaacaaaaa ttaactgaaa gagagttgaa atttgaactt ttagaaaaag   2700

atcctaatgc actcgatgtt tcaaatacag catttggcag agagcattcc ccatgtagtc   2760

cctcaccatt gggtcggcct tcatctgaaa cgagagcttt tccctctcct caaactttgt   2820

tggaggatcc actcagactc tcacctgtgc ttccaggggg aggaggaaga ggcccaagca   2880

gcccagggaa tcccctggac catcagatta ccaatgaaag aggagaacca agctatgaca   2940

ggttaatcga tcctcacagg gctccttctg acactgggtc cctgtcatct ccggtggaac   3000

aggaccgtag gatgatgttt cctccaccag ggcaatcata tcctgattca actcttcctc   3060

cacaaaggga agacagattt tattctaatt ctgaaagact gtctggacca gcagaaccca   3120

gaagttttaa aatgacttct ttggataaaa tggataggtc aatgccttca gaaatggaat   3180

ccagtagaaa tgatgccaaa gatgatcttg gtaatttaaa tgtgcctgat tcatctctcc   3240

ctgctgaaaa tgaagcaact ggccctggcc ttattcctcc acctcttgct ccaatcagcg   3300

gtccattgtt tccagtggat acaaggggcc cattcatgag aagaggacct cctttccccc   3360

cacctcctcc aggaaccatg tttggagctt ctcgaggtta ttttccacca agggatttcc   3420

caggtccacc acatgctcca tttgcaatga gaaacatcta tccaccgagg ggtttacctc   3480

cttaccttca tccgagacct ggattttacc ccaaccccac attctgaagg tagaagcgag   3540

ttcccttcag gattgattcc gccttcaaag gagcctgcta ctggacatcc agaaccacag   3600

caagacacct gacaatattg ttgctttctt caaaagtaat tttgactgat ctcattttca   3660

gtttaagtaa ctgctgttac ttaagtgatt gcacttttct caaattgaag tttaatggaa   3720

taatagttct caggatagta ttttgtaaat aaagatggtt tgaatatgaa tcttatgagt   3780

aaatcatttc cattttatta tattctagat catataactt ttaacttggt gaactaatcc   3840

actcttagag aaacaatagt gggagtttta tatatgtaat cttgcaggtg aggaggcttt   3900

aaattctaaa ggttgtggtg tcttcatgcc aagaactgta ttcactgtgg ttgtagataa   3960

atgtgaaagt aactttatgc ttaatttaat aaattttcat tgattttttt aaaaaaagaa   4020

aactgaaagg agatatagat gaatccacaa ttatagttag aaatttcctc atgccttttt   4080

caataattga tagaactaga cagaaaatca gcaaggagtg ttggctttgg cagcactttc   4140

taaaatcaga atgatgccaa caagattaaa acggttcttg aatatagatt acacaaaatt   4200

ttgtgaagca tttcatgttt ttaaaaagag gaaaaaaaag aaaatcaaca agaatataaa   4260

acaactcaaa atgccattaa ccaaaagaat ctatttggca tttacagaat attccacaca   4320

gtaacagcag aatacacata ttttttttga gtgctgacga aacacctggc aagatagagc   4380

tgtcctaggc cctaaaactc gccacaacaa atttaaaaga gatagtaatc atccagagca   4440

gatgaaaacc agaaatcatt gtagggaatc caattggaaa tcagcataag aaagatatga   4500

aaatccctaa acatttggaa atttaaaaac acacttcaca ataatctatc agtcaaagaa   4560

gtctcaagga aaaattt                                                  4577


<210>  2333
<211>  777
<212>  PRT
<213>  Homo sapiens

<400>  2333


Met Glu Glu Pro Gly Ala Thr Pro Gln Pro Tyr Leu Gly Leu Val Leu 
1               5                   10                  15      


Glu Glu Leu Gly Arg Val Val Ala Ala Leu Pro Glu Ser Met Arg Pro 
            20                  25                  30          


Asp Glu Asn Pro Tyr Gly Phe Pro Ser Glu Leu Val Val Cys Ala Ala 
        35                  40                  45              


Val Ile Gly Phe Phe Val Val Leu Leu Phe Leu Trp Arg Ser Phe Arg 
    50                  55                  60                  


Ser Val Arg Ser Arg Leu Tyr Val Gly Arg Glu Gln Lys Leu Gly Ala 
65                  70                  75                  80  


Thr Leu Ser Gly Leu Ile Glu Glu Lys Cys Lys Leu Leu Glu Lys Phe 
                85                  90                  95      


Ser Leu Ile Gln Lys Glu Tyr Glu Gly Tyr Glu Val Glu Ser Ser Leu 
            100                 105                 110         


Glu Asp Ala Ser Phe Glu Lys Ala Ala Ala Glu Glu Ala Arg Ser Leu 
        115                 120                 125             


Glu Ala Thr Cys Glu Lys Leu Ser Arg Ser Asn Ser Glu Leu Glu Asp 
    130                 135                 140                 


Glu Ile Leu Cys Leu Glu Lys Asp Leu Lys Glu Glu Lys Ser Lys His 
145                 150                 155                 160 


Ser Gln Gln Asp Glu Leu Met Ala Asp Ile Ser Lys Ser Ile Gln Ser 
                165                 170                 175     


Leu Glu Asp Glu Ser Lys Ser Leu Lys Ser Gln Ile Ala Glu Ala Lys 
            180                 185                 190         


Ile Ile Cys Lys Thr Phe Lys Met Ser Glu Glu Arg Arg Ala Ile Ala 
        195                 200                 205             


Ile Lys Asp Ala Leu Asn Glu Asn Ser Gln Leu Gln Thr Ser His Lys 
    210                 215                 220                 


Gln Leu Phe Gln Gln Glu Ala Glu Val Trp Lys Gly Gln Val Ser Glu 
225                 230                 235                 240 


Leu Asn Lys Gln Lys Ile Thr Phe Glu Asp Ser Lys Val His Ala Glu 
                245                 250                 255     


Gln Val Leu Asn Asp Lys Glu Asn His Ile Lys Thr Leu Thr Gly His 
            260                 265                 270         


Leu Pro Met Met Lys Asp Gln Ala Ala Val Leu Glu Glu Asp Thr Thr 
        275                 280                 285             


Asp Asp Asp Asn Leu Glu Leu Lys Val Asn Ser Gln Trp Glu Asn Gly 
    290                 295                 300                 


Ala Asn Leu Asp Asp Pro Pro Lys Gly Ala Leu Lys Lys Leu Ile His 
305                 310                 315                 320 


Ala Ala Lys Leu Asn Val Ser Leu Lys Ser Leu Glu Gly Glu Arg Asn 
                325                 330                 335     


His Ile Ile Ile Gln Leu Ser Glu Val Asp Lys Thr Lys Glu Glu Leu 
            340                 345                 350         


Thr Glu His Ile Lys Asn Leu Gln Thr Gln Gln Ala Ser Leu Gln Ser 
        355                 360                 365             


Glu Asn Ile Tyr Phe Glu Ser Glu Asn Gln Lys Leu Gln Gln Lys Leu 
    370                 375                 380                 


Lys Ile Met Thr Glu Phe Tyr Gln Glu Asn Glu Met Lys Leu Tyr Arg 
385                 390                 395                 400 


Lys Leu Thr Val Glu Glu Asn Tyr Arg Ile Glu Glu Glu Glu Lys Leu 
                405                 410                 415     


Ser Arg Val Glu Glu Lys Ile Ser His Ala Thr Glu Glu Leu Glu Thr 
            420                 425                 430         


Tyr Arg Lys Leu Ala Lys Asp Leu Glu Glu Glu Leu Glu Arg Thr Val 
        435                 440                 445             


His Phe Tyr Gln Lys Gln Val Ile Ser Tyr Glu Lys Arg Gly His Asp 
    450                 455                 460                 


Asn Trp Leu Ala Ala Arg Thr Ala Glu Arg Asn Leu Ser Asp Leu Arg 
465                 470                 475                 480 


Lys Glu Asn Ala His Asn Lys Gln Lys Leu Thr Glu Arg Glu Leu Lys 
                485                 490                 495     


Phe Glu Leu Leu Glu Lys Asp Pro Asn Ala Leu Asp Val Ser Asn Thr 
            500                 505                 510         


Ala Phe Gly Arg Glu His Ser Pro Cys Ser Pro Ser Pro Leu Gly Arg 
        515                 520                 525             


Pro Ser Ser Glu Thr Arg Ala Phe Pro Ser Pro Gln Thr Leu Leu Glu 
    530                 535                 540                 


Asp Pro Leu Arg Leu Ser Pro Val Leu Pro Gly Gly Gly Gly Arg Gly 
545                 550                 555                 560 


Pro Ser Ser Pro Gly Asn Pro Leu Asp His Gln Ile Thr Asn Glu Arg 
                565                 570                 575     


Gly Glu Pro Ser Tyr Asp Arg Leu Ile Asp Pro His Arg Ala Pro Ser 
            580                 585                 590         


Asp Thr Gly Ser Leu Ser Ser Pro Val Glu Gln Asp Arg Arg Met Met 
        595                 600                 605             


Phe Pro Pro Pro Gly Gln Ser Tyr Pro Asp Ser Thr Leu Pro Pro Gln 
    610                 615                 620                 


Arg Glu Asp Arg Phe Tyr Ser Asn Ser Glu Arg Leu Ser Gly Pro Ala 
625                 630                 635                 640 


Glu Pro Arg Ser Phe Lys Met Thr Ser Leu Asp Lys Met Asp Arg Ser 
                645                 650                 655     


Met Pro Ser Glu Met Glu Ser Ser Arg Asn Asp Ala Lys Asp Asp Leu 
            660                 665                 670         


Gly Asn Leu Asn Val Pro Asp Ser Ser Leu Pro Ala Glu Asn Glu Ala 
        675                 680                 685             


Thr Gly Pro Gly Leu Ile Pro Pro Pro Leu Ala Pro Ile Ser Gly Pro 
    690                 695                 700                 


Leu Phe Pro Val Asp Thr Arg Gly Pro Phe Met Arg Arg Gly Pro Pro 
705                 710                 715                 720 


Phe Pro Pro Pro Pro Pro Gly Thr Met Phe Gly Ala Ser Arg Gly Tyr 
                725                 730                 735     


Phe Pro Pro Arg Asp Phe Pro Gly Pro Pro His Ala Pro Phe Ala Met 
            740                 745                 750         


Arg Asn Ile Tyr Pro Pro Arg Gly Leu Pro Pro Tyr Leu His Pro Arg 
        755                 760                 765             


Pro Gly Phe Tyr Pro Asn Pro Thr Phe 
    770                 775         

<210>  2334
<211>  1614
<212>  DNA
<213>  Homo sapiens

<400>  2334
aagctactca gataagaggc tccaagagga catttttgga tgtgaaaaac aatgagaagg     60

aggacaacac acatttacaa tcgtcttaat tttgtactca gaaaaaggat gtgaagacaa    120

tgcacaggga atacaatagt ttcagatctg tgtacagttt ccttttgctt catctcctgc    180

aacaatgtaa tgaagacacc atgatatcat taacatttca cacaaaagga aaatgaggct    240

gaaatggtgt gggcaaggcc caggaatctg gagcatccct aaccaagcag gagagcacct    300

gggatagaga aagtgctcaa gaatgttcac ttactgatta ctacaatcaa aaaaagatac    360

gacactaatt taccacattc ttcttactta ttttatgaga tactattctt ccaaggtgga    420

gaaagtggag aaagtagagt gacgcagcta agggagtaaa tcgaccctca gccaacaagt    480

ggcaaaagcc tgaagaaagt gatcaagatc actgatgacc ccgctgccca tctccaaggg    540

ggcgggtatc acaaccccga cgccacacca cgtatcattc cgcaaaactc ccgcgcctcc    600

cacgcagaac tggcaagagg gaaggcgaga cagcagtgaa cagctggtac gcagcaccca    660

cagcaccgcg gcagcagcta gtgccgactc ccgcctagct cttttgactc tgttcgcggg    720

aagaatgggg aaacagtaag gttgcggcgc ctcccgcgag acgaggtacc tgaggctggc    780

cccgcagtcc cccgccgcac cagcaccgga gcttcacacc ccacttccgg ggtcaagtca    840

ccgccgggaa tcctgtgatc gcagaaaggt agtctcaggt tccgccccta tccaagtccc    900

gcctccactg cctctcgccc tgtatctgtc aacttccggg acgccgcgcg tcactaagca    960

gccaatctcc acttccggac tcatccagcc ccttctccac ccctttcaga gacagcgcga   1020

ttgcgattta ggtttccgcg catttaattg gcgaagctgg agcgctagtc ttcgctgatt   1080

ggtgccgaga aatctgcccc atagacaccc gcggggcgca cagtttcagt cgtccgtggg   1140

tttcccgcca gccgcagtct tggaccataa tcatggtgga catgatggac ttgcccaggt   1200

cgcgcatcaa cgccggcatg ctagctcaat tcatcgacaa gcctgtctgc ttcgtaggga   1260

ggctggaaaa gattcatccc accggaaaaa tgtttattct ttcagatgga gaaggaaaaa   1320

atggaaccat cgagttgatg gaaccccttg atgaagaaat ctctggaatt gtggaagtgg   1380

ttggaagagt aaccgccaag gccaccatct tgtgtacatc ttatgtccag tttaaagaag   1440

atagccatcc ttttgatctt ggactttaca atgaagctgt gaaaattatc catgacttcc   1500

ctcagtttta tcctttaggg attgtgcaac atgattgatc ttgatggatt ttcatacgat   1560

tgtaaatgag ctatattaaa gtctattaaa ggaagccctt cttgtttgag ggag         1614


<210>  2335
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  2335


Met Val Asp Met Met Asp Leu Pro Arg Ser Arg Ile Asn Ala Gly Met 
1               5                   10                  15      


Leu Ala Gln Phe Ile Asp Lys Pro Val Cys Phe Val Gly Arg Leu Glu 
            20                  25                  30          


Lys Ile His Pro Thr Gly Lys Met Phe Ile Leu Ser Asp Gly Glu Gly 
        35                  40                  45              


Lys Asn Gly Thr Ile Glu Leu Met Glu Pro Leu Asp Glu Glu Ile Ser 
    50                  55                  60                  


Gly Ile Val Glu Val Val Gly Arg Val Thr Ala Lys Ala Thr Ile Leu 
65                  70                  75                  80  


Cys Thr Ser Tyr Val Gln Phe Lys Glu Asp Ser His Pro Phe Asp Leu 
                85                  90                  95      


Gly Leu Tyr Asn Glu Ala Val Lys Ile Ile His Asp Phe Pro Gln Phe 
            100                 105                 110         


Tyr Pro Leu Gly Ile Val Gln His Asp 
        115                 120     

<210>  2336
<211>  2230
<212>  DNA
<213>  Homo sapiens

<400>  2336
cttgaccccg gaagtggggt gtgaagctcc ggtgctggtg cggcggggga ctgcggggcc     60

agcctcaggt agcagcagca gcagcagcag cagcagcagc agcagcagca gcagcagcag    120

cagcagcagc aatgtttcac ttcttcagaa agcctccgga atctaaaaag ccctcagtac    180

cagagacaga agcagatgga ttcgtccttt taggagatac aacagatgag caaagaatga    240

cagcaagagg caaaacttcg gacatagagg ccaaccaacc tttggagacc aacaaagaaa    300

attcatccag tgtgactgta tcagaccctg agatggaaaa taaggcaggc cagactctgg    360

agaacagctc attaatggcc gagctcctga gcgatgtgcc gttcaccctg gccccgcatg    420

tgctggcagt acagggcacc atcactgacc ttcccgacca cttactctcc tatgatggca    480

gcgaaaactt atcacggttt tggtatgatt tcactcttga aaattcagtg ctctgtgatt    540

cataaccttt atgtctgttt gcaccttaac agctttaaaa tatgttcgcc tattttatct    600

aacctgtttg atgttctttg ccgtttcact gtttaaggtc ctcagcaagg atcataaagc    660

aaagaaaata gcattatgtt cactactcta tttttaagaa aaaggtacat ttgtatacaa    720

attgaactta agttctactt cctttctccc atataataaa tatacaaatt aggctatgaa    780

ggttttagga aaggactcga ttccttcaga tggtctctca aaatataaca cctcaaattt    840

atcttagaag aactgtgaaa aagaattgtg gcatttttca gtcactacag ctccgaagtc    900

tgagcaagaa gtgggtgtga agtctcctct ctggtttgta ggaagttgaa ttggtgttat    960

tcctgcattt ttttcttcca cagtgtttat gaatgaattc agaaaaaaag ttgccagtta   1020

gcttaatttc ttcagatgca ttgatgtgga aatttaaaac ttgtcctaaa cagcagtgct   1080

agtttgctga tacaaggatg ctagacctgc tctgcgtgct ctttctggag tggcccattt   1140

cggttttctg aaacccatgg cagccctttc catcgtgaat aatcgttgtg ttcccacctt   1200

tgttctctgc ctttttgcta cttcagtgtg ctctctgacc agctttccaa agaactttcc   1260

ctgcttctgc ctcggttgcc atttgctctc cttaccacat atgttcccag tttatgaaga   1320

gatccacatt tcctttcaac ccctctgcct cctgaagaaa aacatctcat gatgatacat   1380

attattgctg ataacaccct tatttagaaa tttgttggcc acaatagaga tggaaatgtt   1440

ttactgctgg aaaaactgaa atcaactcat ttccaattag agtataggca gaacacctag   1500

atatgacttt tagttcttga atatccatta cttactttaa tgaaaacaga actgccattg   1560

gtcaataaac tgtaaaggga agaggtaaat tgtgatagag aattttctat gtcatgggaa   1620

attgaaatca catttatttt gattaccagc aatatgattt gttaactctg tgccaagttt   1680

taagtatatt ttttcacaaa gatagagtgc catagtgaaa ctaaacactg tgcataaagg   1740

tacatgaatt attccagttt taaagtatta tgcatgtttg tttaataaat gtggcatggt   1800

tttaatacaa atgctatgtt atttaaaagt tagaggaaca tttctattga caaaaatatg   1860

cttcatttac atataatgtt accatatggt gttaatgatt aaattagatc tttacatagt   1920

tcttacaaag catcagtcta ggaaatatga cttattactg atgcaaacgt gaacattttg   1980

tagtagtttt gtaaaagaac atccttttca aatatctgtg ttaatgtacc cttgaaatta   2040

aatgcaagca catagtcagt ttgtctaatt ttgtgtgaaa ttttgtcgaa aatacctaaa   2100

catttcatct atatttgtgc ctaccatgtt ataaatgttc ataagtacct tcatgtgtct   2160

ataaaaaatg ttatatttaa ataaatgtga attaaaataa aatttttgat tattttcaga   2220

tccagaaaaa                                                          2230


<210>  2337
<211>  137
<212>  PRT
<213>  Homo sapiens

<400>  2337


Met Phe His Phe Phe Arg Lys Pro Pro Glu Ser Lys Lys Pro Ser Val 
1               5                   10                  15      


Pro Glu Thr Glu Ala Asp Gly Phe Val Leu Leu Gly Asp Thr Thr Asp 
            20                  25                  30          


Glu Gln Arg Met Thr Ala Arg Gly Lys Thr Ser Asp Ile Glu Ala Asn 
        35                  40                  45              


Gln Pro Leu Glu Thr Asn Lys Glu Asn Ser Ser Ser Val Thr Val Ser 
    50                  55                  60                  


Asp Pro Glu Met Glu Asn Lys Ala Gly Gln Thr Leu Glu Asn Ser Ser 
65                  70                  75                  80  


Leu Met Ala Glu Leu Leu Ser Asp Val Pro Phe Thr Leu Ala Pro His 
                85                  90                  95      


Val Leu Ala Val Gln Gly Thr Ile Thr Asp Leu Pro Asp His Leu Leu 
            100                 105                 110         


Ser Tyr Asp Gly Ser Glu Asn Leu Ser Arg Phe Trp Tyr Asp Phe Thr 
        115                 120                 125             


Leu Glu Asn Ser Val Leu Cys Asp Ser 
    130                 135         

<210>  2338
<211>  439
<212>  DNA
<213>  Homo sapiens

<400>  2338
ggggtgtgaa gctccggtgc tggtgcggcg ggggactgcg gggccagcct caggtagcag     60

cagcagcagc agcagcagca gcagcagcag cagcagcagc agcagcagca gcagcaatgt    120

ttcacttctt cagaaagcct ccggaatcta aaaagccctc agtaccagag acagaagcag    180

atggattcgt ccttttagtg gcgtgatctc ggctcactgc aacctccgcc tcctgggttc    240

aaacgattct cctgcctcag cctcctgagt agctgggact acaggggcct gccaccacgc    300

ccagctaatt tttttttttt ttgtattttc agtagagacg gggtttcacc atgttggcca    360

ggatggtctt gatctcttga catcatgatc cgcccgcctc ggcctcccaa agtcctggga    420

ttacaggcgt gagccaccg                                                 439


<210>  2339
<211>  57
<212>  PRT
<213>  Homo sapiens

<400>  2339


Trp Arg Asp Leu Gly Ser Leu Gln Pro Pro Pro Pro Gly Phe Lys Arg 
1               5                   10                  15      


Phe Ser Cys Leu Ser Leu Leu Ser Ser Trp Asp Tyr Arg Gly Leu Pro 
            20                  25                  30          


Pro Arg Pro Ala Asn Phe Phe Phe Phe Cys Ile Phe Ser Arg Asp Gly 
        35                  40                  45              


Val Ser Pro Cys Trp Pro Gly Trp Ser 
    50                  55          

<210>  2340
<211>  577
<212>  DNA
<213>  Homo sapiens

<400>  2340
aaccttttct ccctggtgga ggaaccactt gcatgagaat aagaggttgt tccccaggcc     60

atcagactcc aaacagttat gcaactggag cctcctgagg atgacccctt ctgcctggga    120

cccttagatc agcctctaga gaagctttga ctgctgtttc cccaaaacag caccccctgc    180

catcaggaag caaaagccat gttggttcac cacatgtatc gcatcctgat aatgtgaagt    240

gaaaaagtag agcctggaag cctttgtaag atgactgtgc cagaggagga agataaatat    300

ctcgatgcta tggaggcctg tcagctcttt gaagtatctg ggcaatatca agatttctac    360

ttcagatgaa aaaacaaata gttattcatt gaccctgttg ccgccaagaa agaggtgaaa    420

ggtgaacccc caacccacgg aaagatccag ccaagtaagg aactgcaaaa tattgaatga    480

ctaattctcc aaacaaggag aacaagaaga tttatactag ccatgcaagg aatctttgga    540

agtctaacag acctgacttg aagagaaggc tttaaac                             577


<210>  2341
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  2341


Met Leu Trp Arg Pro Val Ser Ser Leu Lys Tyr Leu Gly Asn Ile Lys 
1               5                   10                  15      


Ile Ser Thr Ser Asp Glu Lys Thr Asn Ser Tyr Ser Leu Thr Leu Leu 
            20                  25                  30          


Pro Pro Arg Lys Arg 
        35          

<210>  2342
<211>  618
<212>  DNA
<213>  Homo sapiens

<400>  2342
caggccatca gactccaaac agttatgcaa ctggagcctc ctgaggatga ccccttctgc     60

ctgggaccct tagatcagcc tctagagaag ctttgactgc tgtttcccca aaacagcacc    120

ccctgccatc aggaagcaag ctgatcaagg agagaagata aggcatggat attcagttta    180

aaatggtaga gaaccataat aatacctacc ttgaagtgat gatataaact acatgacaca    240

gagtacttgc ttcacacagt gttggaacac acagagctgc cacctggaaa tccctgctca    300

tctaagggtt gcatctagac tctgaaagcc atgttggttc accacatgta tcgcatcctg    360

ataatgtgaa gtgaaaaagt agagcctgga agcctttgta agatgactgt gccagaggag    420

gaagataaat atctcgatgc tatggaggcc tgtcagctct ttgaagtatc tgggcaatat    480

caagatttct acttcagatg aaaaaacaaa tagttattca ttgaccctgt tgccgccaag    540

aaagagaaac tcaggaattc tgctcttggg aagatggatt agatgtatta ttctttactc    600

ttcccactaa ctacaact                                                  618


<210>  2343
<211>  57
<212>  PRT
<213>  Homo sapiens

<400>  2343


Met Leu Trp Arg Pro Val Ser Ser Leu Lys Tyr Leu Gly Asn Ile Lys 
1               5                   10                  15      


Ile Ser Thr Ser Asp Glu Lys Thr Asn Ser Tyr Ser Leu Thr Leu Leu 
            20                  25                  30          


Pro Pro Arg Lys Arg Asn Ser Gly Ile Leu Leu Leu Gly Arg Trp Ile 
        35                  40                  45              


Arg Cys Ile Ile Leu Tyr Ser Ser His 
    50                  55          

<210>  2344
<211>  565
<212>  DNA
<213>  Homo sapiens

<400>  2344
actttctgga ttttgctaca gaagagaaca ccatgtgtag ggaacctgaa ttttttgtaa     60

taggccgtaa gcatgcctgc cctttggcct ggaaagagac actatatctt ccagggctgt    120

ttgctgtgta aacatccttg aaaagacagc cttgaacaaa gggcagtcaa tagttctact    180

caaaagacat ggagaaatgc aaaagaccca tggagatttg tcttctaatc ggcagcatct    240

tgcaaggaga acaagaagat ttatactagc catgcaagga atctttggaa gtctaacaga    300

cctgacttga agagaaggct ttaaacaaga aattcttcat tctggaacag tgattcttaa    360

agtgcggttc agagaccctg ggagacactg acattctttc agagtgtgag tgaggatttc    420

ctctttgcaa ctacaatctg taaccctttg tatcctgaga aaccgaatta atctgcaccc    480

tctctgtcaa agcttcctga tcatcacagc tggaaacaat ctctaacttt tgaaaatctg    540

taacaactac tgagatgtaa tatgg                                          565


<210>  2345
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  2345


Met Gln Lys Thr His Gly Asp Leu Ser Ser Asn Arg Gln His Leu Ala 
1               5                   10                  15      


Arg Arg Thr Arg Arg Phe Ile Leu Ala Met Gln Gly Ile Phe Gly Ser 
            20                  25                  30          


Leu Thr Asp Leu Thr 
        35          

<210>  2346
<211>  774
<212>  DNA
<213>  Homo sapiens

<400>  2346
atccttgaaa agacagcctt gaacaaaggg cagtcaatag ttctactcaa aagacatgga     60

gaaatgcaaa agacccatgg agatttgtct tctaatcggc agcatcttgc aaggagaaca    120

agaagattta tactagccat gcaaggaatc tttggaagtc taacagacct gacttgaaga    180

gaaggcttta aacaagaaat tcttcattct ggaacagtga ttcttaaagt gcggttcaga    240

gaccctggga gacactgaca ttctttcaga gtgtgagtga ggatttcctc tttgcaacta    300

caatctgtgt aaggttggat tttctttaca tacataaact aaaataagat tgcaataaga    360

tgaatgcaga agcagataag agaatccagc tgtcttaagt tagacttcac agagatttgc    420

aaaaatccaa acaagaccac tctcgtcatt aaagttattt tccatttgtt atggtgaact    480

tattttgcag gaaatttgtt atttatagta acatacaatt ttgttttttg atcattttaa    540

ataaattaat aaatattata agttttctat ttttaaaatt atacatgtca gaaaagaaca    600

gttctttcag gtcctcaaca attttaagac tattaacttg ttttggatca aaaagttcta    660

gatttgctat tctagacatg aatcctttga aattaattgg cttcataagt atatttttca    720

agtttgtggc ttgtcctgta accttctact gtgtagaagt tttaaatttt aatt          774


<210>  2347
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  2347


Met Gln Lys Thr His Gly Asp Leu Ser Ser Asn Arg Gln His Leu Ala 
1               5                   10                  15      


Arg Arg Thr Arg Arg Phe Ile Leu Ala Met Gln Gly Ile Phe Gly Ser 
            20                  25                  30          


Leu Thr Asp Leu Thr 
        35          

<210>  2348
<211>  532
<212>  DNA
<213>  Homo sapiens

<400>  2348
aaaccaacaa cgaaggaaca aaaactttga tctgttcaaa gcgaatacaa gcctgccacc     60

tggaggaagg actgcacccc ttcagcctca attatgttca attccacaaa tagttatgtg    120

ccgggcattg tgcttccttc atcagaacat ttatcaagtt tgcatgttta ttagccacct    180

ctgaaatatt aaaaaatgac tgccattgat ctctgagtgg cctgtggact tggcttacgg    240

cccatcaagg cctgggtaac acagcattgg accatgccaa cacagaaact cagaggggcc    300

aggtggctgc aggccagaag gagcagtggg aaggactgtg gcccagagga gctgaatagc    360

atcagaggag tgacctctgt acctggtcat gcagcagcca cccatgcagg ccactgggag    420

aaacccatgg tgggtgccca gtgggcctca tggacgccct gacaccagag gcggaagggg    480

gtgtattttc tggattccca tctctctttg tttcaataaa gacatctgca ac            532


<210>  2349
<211>  47
<212>  PRT
<213>  Homo sapiens

<400>  2349


Met Gln Gln Pro Pro Met Gln Ala Thr Gly Arg Asn Pro Trp Trp Val 
1               5                   10                  15      


Pro Ser Gly Pro His Gly Arg Pro Asp Thr Arg Gly Gly Arg Gly Cys 
            20                  25                  30          


Ile Phe Trp Ile Pro Ile Ser Leu Cys Phe Asn Lys Asp Ile Cys 
        35                  40                  45          

<210>  2350
<211>  900
<212>  DNA
<213>  Homo sapiens

<400>  2350
gttggcgctt ccggtggcct gcgaccccgt aattgcctcg gtgatgtcgt gggttcaagc     60

agcctccttg atccagggcc ctggagacaa aggggacgtg tttgacgaag aagcagacga    120

gtcgctcctg gcgcagcggg aatggcagag taacatgcaa agacgagtca aagaaggtta    180

tagagatgga atagatgctg gcaaagcagt tactcttcaa cagggcttca atcaaggtta    240

taagaaaggt gcagaagtca ttttaaacta tggacgactc cgaggaacat tgagtgcttt    300

gctctcctgg tgtcaccttc ataataataa ttcaactttg atcaataaaa taaacaatct    360

tctggatgca gttggccagt gtgaagagta tgtgctcaaa catctgaaat caatcactcc    420

accgtcccat gttgtagatt tattggactc cattgaggat atggaccttt gtcatgtagt    480

tccagctgag aaaaagattg atgaagctaa agatgaaaga ctctgtgaaa ataatgctga    540

gtttaacaaa aactgtagca agagccatag tgggatagat tgttcatatg tagaatgttg    600

tagaacacag gagcatgcac attcagaaaa cccaagcccc acatggattt tggaacagac    660

agccagttta gttaaacagc tgggcctatc agtagatgta ttacaacacc tcaaacaact    720

ataaaattac cttccctttt ctaatgaaaa taatgttcag aacatttggt ttcctaacaa    780

tcgaaatttg tactggtttc tgcatcaaac acctcaactg tagggttacc ctttatggaa    840

gtttgaaatt aacactattg tcttcaaaat taacactatt aaatgtaata taagcctttt    900


<210>  2351
<211>  226
<212>  PRT
<213>  Homo sapiens

<400>  2351


Met Ser Trp Val Gln Ala Ala Ser Leu Ile Gln Gly Pro Gly Asp Lys 
1               5                   10                  15      


Gly Asp Val Phe Asp Glu Glu Ala Asp Glu Ser Leu Leu Ala Gln Arg 
            20                  25                  30          


Glu Trp Gln Ser Asn Met Gln Arg Arg Val Lys Glu Gly Tyr Arg Asp 
        35                  40                  45              


Gly Ile Asp Ala Gly Lys Ala Val Thr Leu Gln Gln Gly Phe Asn Gln 
    50                  55                  60                  


Gly Tyr Lys Lys Gly Ala Glu Val Ile Leu Asn Tyr Gly Arg Leu Arg 
65                  70                  75                  80  


Gly Thr Leu Ser Ala Leu Leu Ser Trp Cys His Leu His Asn Asn Asn 
                85                  90                  95      


Ser Thr Leu Ile Asn Lys Ile Asn Asn Leu Leu Asp Ala Val Gly Gln 
            100                 105                 110         


Cys Glu Glu Tyr Val Leu Lys His Leu Lys Ser Ile Thr Pro Pro Ser 
        115                 120                 125             


His Val Val Asp Leu Leu Asp Ser Ile Glu Asp Met Asp Leu Cys His 
    130                 135                 140                 


Val Val Pro Ala Glu Lys Lys Ile Asp Glu Ala Lys Asp Glu Arg Leu 
145                 150                 155                 160 


Cys Glu Asn Asn Ala Glu Phe Asn Lys Asn Cys Ser Lys Ser His Ser 
                165                 170                 175     


Gly Ile Asp Cys Ser Tyr Val Glu Cys Cys Arg Thr Gln Glu His Ala 
            180                 185                 190         


His Ser Glu Asn Pro Ser Pro Thr Trp Ile Leu Glu Gln Thr Ala Ser 
        195                 200                 205             


Leu Val Lys Gln Leu Gly Leu Ser Val Asp Val Leu Gln His Leu Lys 
    210                 215                 220                 


Gln Leu 
225     

<210>  2352
<211>  660
<212>  DNA
<213>  Homo sapiens

<400>  2352
tccggtggcc tgcgaccccg taattgcctc ggtgatgtcg tgggttcaag cagcctcctt     60

gatccagggc cctggagaca aaggggacgt gtttgacgaa gaagcagacg agtcgctcct    120

ggcgcagcgg gaatggcaga gtaacatgca aagacgagtc aaagaaggtt atagagatgg    180

aatagatgct ggcaaagcag ttactcttca acagggcttc aatcaaggtt ataagaaagg    240

tgcagaagtc attttaaact atggacgact ccgaggaaca ttgaggtaat ttttaaagtc    300

taaatgctga atcattttaa cctcaatact actggaggat gtttctgtat aaataaagtg    360

tttaaactga aatgcttttc ctggtgctaa atacactaaa gcgtgtcgca gatcatagaa    420

ttatattgcc ttcaaaaagt caaaatcttt atcagctcat ctactttaat gtgtgaacta    480

catattgtct tttcgtgcaa agaaatggta agaagatgta tacttctgct acctgaacaa    540

ttatctatct cattgaaagg tcttcagatt ttgaataaaa cttgtagtac ttccacacag    600

tatgacagac ctctagacta gaagtacatg atgaaaatag ttggtaatta agataaaatt    660


<210>  2353
<211>  84
<212>  PRT
<213>  Homo sapiens

<400>  2353


Met Ser Trp Val Gln Ala Ala Ser Leu Ile Gln Gly Pro Gly Asp Lys 
1               5                   10                  15      


Gly Asp Val Phe Asp Glu Glu Ala Asp Glu Ser Leu Leu Ala Gln Arg 
            20                  25                  30          


Glu Trp Gln Ser Asn Met Gln Arg Arg Val Lys Glu Gly Tyr Arg Asp 
        35                  40                  45              


Gly Ile Asp Ala Gly Lys Ala Val Thr Leu Gln Gln Gly Phe Asn Gln 
    50                  55                  60                  


Gly Tyr Lys Lys Gly Ala Glu Val Ile Leu Asn Tyr Gly Arg Leu Arg 
65                  70                  75                  80  


Gly Thr Leu Arg 
                

<210>  2354
<211>  804
<212>  DNA
<213>  Homo sapiens

<400>  2354
ctgcgacccc gtaattgcct cggtgatgtc gtgggttcaa gcagcctcct tgatccaggg     60

ccctggagac aaaggggacg tgtttgacga agaagcagac gagtcgctcc tggcgcagcg    120

ggaatggcag agtaacatgc aaagacgagt caaagaaggt tatagagatg gaatagatgc    180

tggcaaagca gttactcttc aacagggctt caatcaaggt tataagaaag gtgcagaagt    240

cattttaaac tatggacgac tccgaggaac attgagttgg ccagtgtgaa gagtatgtgc    300

tcaaacatct gaaatcaatc actccaccgt cccatgttgt agatttattg gactccattg    360

aggatatgga cctttgtcat gtagttccag ctgagaaaaa gattgatgaa gctaaagatg    420

aaagactctg tgaaaataat gctgagttta acaaaaactg tagcaagagc catagtggga    480

tagattgttc atatgtagaa tgttgtagaa cacaggagca tgcacattca gaaaacccaa    540

gccccacatg gattttggaa cagacagcca gtttagttaa acagctgggc ctatcagtag    600

atgtattaca acacctcaaa caactataaa attaccttcc cttttctaat gaaaataatg    660

ttcagaacat ttggtttcct aacaatcgaa atttgtactg gtttctgcat caaacacctc    720

aactgtaggg ttacccttta tggaagtttg aaattaacac tattgtcttc aaaattaaca    780

ctattaaatg taatataagc cttt                                           804


<210>  2355
<211>  87
<212>  PRT
<213>  Homo sapiens

<400>  2355


Met Ser Trp Val Gln Ala Ala Ser Leu Ile Gln Gly Pro Gly Asp Lys 
1               5                   10                  15      


Gly Asp Val Phe Asp Glu Glu Ala Asp Glu Ser Leu Leu Ala Gln Arg 
            20                  25                  30          


Glu Trp Gln Ser Asn Met Gln Arg Arg Val Lys Glu Gly Tyr Arg Asp 
        35                  40                  45              


Gly Ile Asp Ala Gly Lys Ala Val Thr Leu Gln Gln Gly Phe Asn Gln 
    50                  55                  60                  


Gly Tyr Lys Lys Gly Ala Glu Val Ile Leu Asn Tyr Gly Arg Leu Arg 
65                  70                  75                  80  


Gly Thr Leu Ser Trp Pro Val 
                85          

<210>  2356
<211>  1228
<212>  DNA
<213>  Homo sapiens

<400>  2356
ccggttaatg gttttgacaa gcagggcacc acggggcata aaattgtatc atccagcctc     60

cttccagcag ctctctccag ttcttgtctg tgatgatgcg tacgttgctc tgccgcctgt    120

gggtccaggg agcaccccca agcaacagta ccaggactgc cagcggaact gcaagactcc    180

tggagggtgc catgtctgcc gcttgcccac ctcacagcaa gcgtggcggc ccaacactag    240

gttttttaaa aactgtgact atcagtgttt taaaaattgc ccggtaactc tagacttcaa    300

aagtgggata agtaatgata aaccaataat aaacttagga gaagcatagt ctgctttagt    360

tatattgtta tgccatatta tggtcagtaa cacagtaaag gcctaattca tctgctttct    420

aaattggttc tgtacttttc tagaaaagcc tacatgtata tacttagtta cagctgcact    480

tctccattac ttatttttag gaaggttata gagatggaat agatgctggc aaagcagtta    540

ctcttcaaca gggcttcaat caaggttata agaaaggtgc agaagtcatt ttaaactatg    600

gacgactccg aggaacattg agtgctttgc tctcctggtg tcaccttcat aataataatt    660

caactttgat caataaaata aacaatcttc tggatgcagt tggccagtgt gaagagtatg    720

tgctcaaaca tctgaaatca atcactccac cgtcccatgt tgtagattta ttggactcca    780

ttgaggatat ggacctttgt catgtagttc cagctgagaa aaagattgat gaagctaaag    840

atgaaagact ctgtgaaaat aatgctgagt ttaacaaaaa ctgtagcaag agccatagtg    900

ggatagattg ttcatatgta gaatgttgta gaacacagga gcatgcacat tcagaaaacc    960

caagccccac atggattttg gaacagacag ccagtttagt taaacagctg ggcctatcag   1020

tagatgtatt acaacacctc aaacaactat aaaattacct tcccttttct aatgaaaata   1080

atgttcagaa catttggttt cctaacaatc gaaatttgta ctggtttctg catcaaacac   1140

ctcaactgta gggttaccct ttatggaagt ttgaaattaa cactattgtc ttcaaaatta   1200

acactattaa atgtaatata agcctttt                                      1228


<210>  2357
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  2357


Met Val Leu Thr Ser Arg Ala Pro Arg Gly Ile Lys Leu Tyr His Pro 
1               5                   10                  15      


Ala Ser Phe Gln Gln Leu Ser Pro Val Leu Val Cys Asp Asp Ala Tyr 
            20                  25                  30          


Val Ala Leu Pro Pro Val Gly Pro Gly Ser Thr Pro Lys Gln Gln Tyr 
        35                  40                  45              


Gln Asp Cys Gln Arg Asn Cys Lys Thr Pro Gly Gly Cys His Val Cys 
    50                  55                  60                  


Arg Leu Pro Thr Ser Gln Gln Ala Trp Arg Pro Asn Thr Arg Phe Phe 
65                  70                  75                  80  


Lys Asn Cys Asp Tyr Gln Cys Phe Lys Asn Cys Pro Val Thr Leu Asp 
                85                  90                  95      


Phe Lys Ser Gly Ile Ser Asn Asp Lys Pro Ile Ile Asn Leu Gly Glu 
            100                 105                 110         


Ala 
    

<210>  2358
<211>  792
<212>  DNA
<213>  Homo sapiens

<400>  2358
gaaagaaatg agagaaagat ggatctgagc cttttaggaa gacgtcttca tttgagatgg     60

tgtatgacag tagatagtgt cagaggtgag catacaagag cagaagaatg caatgtggct    120

ttggggctct cccatcaaga agtggggtcc atttcctgat ccctggagtc tggactcagg    180

agcagcctgt gacttgcact gacatcaatg gataatgaaa tggatggaga cagagttgtg    240

caaattccag aagctacgcc ttgagggctc ttgcagattt tgcttttgac ctcttgaaac    300

tgccctgaga ccactaggaa ggaataccta tctggttttc tggaggaaga gagtcacatg    360

gagaagaact gaggcagcca ccaactgcca gacatgtgac caccagctct gctgacccca    420

cagctcaaag aagctgcaca gatgagctga ggccacactc ttcagggaac aatccgcaca    480

gtcctgagag acagcaactc cttgctcttc tgagccacta ggctttggaa cagttcattg    540

cctcttttac atgacatact ctaattgcat catcttgttc aatgctcaca acaaccctgc    600

aaggttctta ttaattttcc attttacaga taagaaaact gagcctcaca gagtagatgc    660

aaaaccgtta agtggcagga ctggaatttg cactcacatc tatgtggccc taaaggccac    720

cctctcccca tttcactggc ccatcaaaaa ccacagagac cagataacaa gagcttgtca    780

tagtgctgac ag                                                        792


<210>  2359
<211>  46
<212>  PRT
<213>  Homo sapiens

<400>  2359


Met Asp Leu Ser Leu Leu Gly Arg Arg Leu His Leu Arg Trp Cys Met 
1               5                   10                  15      


Thr Val Asp Ser Val Arg Gly Glu His Thr Arg Ala Glu Glu Cys Asn 
            20                  25                  30          


Val Ala Leu Gly Leu Ser His Gln Glu Val Gly Ser Ile Ser 
        35                  40                  45      

<210>  2360
<211>  920
<212>  DNA
<213>  Homo sapiens

<400>  2360
tgtgatcctc ccacctcagt ctcctgagtg ccaccaattg tgtgccacca agcctgacta     60

attttaaaaa ttttttgaag agaccaggtt tcactgtgtt gctcagggtg atcttgaact    120

tctgggctca agcaatcctc ctgccttagc ctcctcaaat gttggcccgt agttttaagt    180

agtaactcct tttctgtact tctgaagttt ttatcatcgt atgtaaaatt tagtgatgtc    240

acatgaattt gcttaaagta tagattattt tcataattct aggaaaccag atattaagca    300

ctaaacttat tctaggagtt tcgttattat atatatatat atatatatat atatatatat    360

atatatatat atatgacaaa gccccatctc tatatattta taaaacacaa aggccatggg    420

tggggaatgg atggcaggca ccatgtctgg cagcaaaggt ggcaagaaga aggccctgaa    480

acagcccaag aagcaggcca aggagaagga cgaggaagat aaggctttca agcagaaaca    540

aaaagaggag cagaagaaac tcgaggagct aaacatgaag gccgtgggga agtggcccct    600

ggccacaggt ggaattaaga aatttgccaa aaagtgagct gttgcttgtg cctgaggaaa    660

tggtaaccct ttatttcatc catattgaaa catctgtatt ccctgccata acaccttttg    720

ccacctatag ctggaattaa gtgttgtctt ggagctgttg tacatttaag aataaacttt    780

tgtaaaataa ataaataaat aaatgccagg cgcagtggct catgcctgta atctcagtac    840

tttgggatgc cgaggtggtg gatcacttga gatcaggagt tcaaccagcc tggccaacat    900

ggtgaaaccc catctgtcct                                                920


<210>  2361
<211>  73
<212>  PRT
<213>  Homo sapiens

<400>  2361


Met Gly Gly Glu Trp Met Ala Gly Thr Met Ser Gly Ser Lys Gly Gly 
1               5                   10                  15      


Lys Lys Lys Ala Leu Lys Gln Pro Lys Lys Gln Ala Lys Glu Lys Asp 
            20                  25                  30          


Glu Glu Asp Lys Ala Phe Lys Gln Lys Gln Lys Glu Glu Gln Lys Lys 
        35                  40                  45              


Leu Glu Glu Leu Asn Met Lys Ala Val Gly Lys Trp Pro Leu Ala Thr 
    50                  55                  60                  


Gly Gly Ile Lys Lys Phe Ala Lys Lys 
65                  70              

<210>  2362
<211>  3613
<212>  DNA
<213>  Homo sapiens

<400>  2362
cccttccggc ggcctctccg ggcccagaag ctcctcaagt cggcctctcc agacccactt     60

gcagcctccc ggtatcctct ccgggcccag ctcttcctcc cggctgcgtc tgcaggcccg    120

actcctgcct cccaacaacc tctttggact cagtgcctgc ccagctcctg gtggccttgg    180

tcggcccaca gcttcctgaa gccaagctcc ccaggcccag ctcgggcctc atggtggcct    240

ctcctggctc agctcctgcc ctccgacggc gtctccaggc cccaaatggc ctcgggtcgg    300

tgggcttctc caggcccagc ttgggcctcc cggcggcctc tgcaggctca agtggtcctg    360

aagtcagcct ctccaggccc agctccggcc tcccagcaag caagctcttt tggctcagct    420

cctgcccagc tcccgccggc ttttgtagac cctgaacttt ctccagcgat gctcctcagt    480

cccacctgcc tcccggtggc ctgtacaggc ccaggtctgg ctggagaaca gcctctgcag    540

gccccactct tgcctcctag gggcatctcc aggcccagct ctggcctcac ggcggcctcc    600

cgggaccaag tccctgcctg cctcccagca gcctgtgtgc ggcccagctc ctccgtcacg    660

gtggcctgtt caggcccaac tcatgcctct ggcacccttt cgagaggcgt gagcccctgc    720

ctcacattgg cctctctcac gctgagggag ttcagcgtgg gcccctgtct cacactggcc    780

tctctcacgc tgagggaggt cagcatgagc ccctgcctca cactggtctc tctcacgctg    840

agagcaatcc tccctcacgc tggcctgttg agacccagct catgcctctg ttggcctttc    900

caggcccagc ccctgcctgt tggcggcctc tagatgtcca gcctctacct caacagtggg    960

ccctccacgc ccacctcttg cctggccgtg gcctcttcgg gccaggctcc cgccttgggg   1020

cagcccccgc aggcccagct cctgcctcac ggccctccgg aggccaagct catgcgtcag   1080

ggcagcctct cccagcctgg cgtttgctcc tttgcatggg ctccaggccc tggacttcct   1140

ccagtcggcc tctccaggcc cagctcttcc tcccggcagc ctctgcagga ccagactgtc   1200

gtcaagtagg cctgtccagg gacagctcct tcctcccggc ggcctctgta ggcccagact   1260

gtcatcaagt aggcctgtcc aaggacagct cctgcctccc ggtggcctct gttggcccaa   1320

gtcgtcctca agtctgcctc cccaggccca gctctggcct ctcggcggcc tctccaggtg   1380

caaaagttcc tcgagtccgt ctctccaggc tcagctcctc ctgtctccca gtggcctctt   1440

tcagcccagc ccagctcatg cctcccggtg gccttcccag gccctgcttt tgactttccg   1500

cggcctctgc aggccccgaa cttgaccacc agtcggcctc tccaggcctg gcctcctgcc   1560

tgttgacagc cactagaggc ccagcctcta cctcaacagt gtgccctcca ggcccacctc   1620

ttgcctcgcc gtggcctcct cgggccaggc tcccacctcg ggacggcctc cgcaggccca   1680

gctcctgcct cacggaggcc ctctggaggc caagctcatg cgtcgtggcg gcctctcccg   1740

gcctggcgtt tgctcctttg catgggctcc aggtcctgca cttcctccag tcggcctctc   1800

caggcccagc tcttcctccc ggcagcctct gcaggaccag actgtcgtca agtaggcctg   1860

tccagggaca gctcctgctt cccggcggcc tctgtaggcc cagactgtca tcaagtaggc   1920

ctgtccaggg acagctcctg cctctcggtg gcctctgcag gcccaaatca tcctccccag   1980

gcccagctcc ggcctctcgg cggcctctcc aggtgcaaaa gtttgaatca gtatctccag   2040

gcccaggtcc tcctgtctcc cagtggcctc ttttggccca gcccagttca tgcctcctgg   2100

tggccttccc aggccccact tttgactttc cgcggcctct gcagattccg aacttgacct   2160

ccagtcggcc tctcctggcc cggcctcctg ccttccgaag gcctgcacag gcccagtctc   2220

tgcctcacag cggactctcc acgcccagct agctctcgcc tcactgcagc ctcccgagtc   2280

caaagctcct gcctcttggc cgcttcggca ggcccagctc ccacctgcca gtggcctctt   2340

ctggcccatg gggttcattc ctcacaacgg cctttccagg cccatttttt cccttccgac   2400

tgcctctcag gacccagaac ctctgggccc acttgaggag atgcagccag gaggaacagc   2460

tgggcttgca gaggctgcca tgcgggaggc agaggctggg cctcctgaag tcggcctctc   2520

cagacccact tgcagactcc cggcatcctc tctgggctca gctcttcctc ccggctgcgt   2580

ctccaggccc gactccggcc tcccaacaac ctctttggac tcagctcccg cccagctccc   2640

ggtggccctg gttggcccac aacttcctga agccaagctc cccagcccca gctcaggcct   2700

cacggtggcc tctccaggct cagctcctgc cctctgacag cgtctccagg ccccgaacgg   2760

cctccagtcg gtggattcct ctatgcccag cttgggcctc ccggcagcct ctgctggccc   2820

aaatcgtcct gaagtcgccc tctccaggcc cagctccggc ctcccggcag cctctccagg   2880

cgcaacgcgt cgtcaacgag ggcccctccg gggtcagctc ctgcctctca tcagcctcta   2940

gaggccagtc tggcggcctc tgcaggccca gactgccctt gagtcaggct ctccagggcc   3000

agctccagcc tcctggcaga ctctgcaggc ccaagtcgtc ctcaagtcgg cctggaagtg   3060

ggcctggaag agctgcattt tggcctcccc gggcccagct ccgtcctctc ggcggcctct   3120

ccaggtgcaa aacttcctcg agtcagcctc tccaggtcca gctcctcctg cctcccagtg   3180

gcctctttca gcccagccca gctcgtggct gtaggcagcc ttcccaggcc ctgcttttga   3240

cttttggcgg cctcttcagg cccagaactt gatctccagt cagcttttgc aggcccggca   3300

tcctgcctcc cgaaggcctg cacgggcccg gcctcggaat cacagcagac tctccacgcc   3360

cagctagctc tcgcctcact gtggcctccc cagtccaaag ctcctgcctt tcggccgctt   3420

cggcaggccc agctcccgcc tgccagtggc ctctttaggc ccagctcatt cctcacattg   3480

gcctttccag gccccgtttt tcccttccgg cagcctcttg gcctctaatt ttttttatct   3540

tttgtgtata aatcccaaaa tatggaattt tggaacattt ccaccattat ataaatattt   3600

tggtaggtaa ttt                                                      3613


<210>  2363
<211>  215
<212>  PRT
<213>  Homo sapiens

<400>  2363


Met Ala Ser Gly Arg Trp Ala Ser Pro Gly Pro Ala Trp Ala Ser Arg 
1               5                   10                  15      


Arg Pro Leu Gln Ala Gln Val Val Leu Lys Ser Ala Ser Pro Gly Pro 
            20                  25                  30          


Ala Pro Ala Ser Gln Gln Ala Ser Ser Phe Gly Ser Ala Pro Ala Gln 
        35                  40                  45              


Leu Pro Pro Ala Phe Val Asp Pro Glu Leu Ser Pro Ala Met Leu Leu 
    50                  55                  60                  


Ser Pro Thr Cys Leu Pro Val Ala Cys Thr Gly Pro Gly Leu Ala Gly 
65                  70                  75                  80  


Glu Gln Pro Leu Gln Ala Pro Leu Leu Pro Pro Arg Gly Ile Ser Arg 
                85                  90                  95      


Pro Ser Ser Gly Leu Thr Ala Ala Ser Arg Asp Gln Val Pro Ala Cys 
            100                 105                 110         


Leu Pro Ala Ala Cys Val Arg Pro Ser Ser Ser Val Thr Val Ala Cys 
        115                 120                 125             


Ser Gly Pro Thr His Ala Ser Gly Thr Leu Ser Arg Gly Val Ser Pro 
    130                 135                 140                 


Cys Leu Thr Leu Ala Ser Leu Thr Leu Arg Glu Phe Ser Val Gly Pro 
145                 150                 155                 160 


Cys Leu Thr Leu Ala Ser Leu Thr Leu Arg Glu Val Ser Met Ser Pro 
                165                 170                 175     


Cys Leu Thr Leu Val Ser Leu Thr Leu Arg Ala Ile Leu Pro His Ala 
            180                 185                 190         


Gly Leu Leu Arg Pro Ser Ser Cys Leu Cys Trp Pro Phe Gln Ala Gln 
        195                 200                 205             


Pro Leu Pro Val Gly Gly Leu 
    210                 215 

<210>  2364
<211>  1122
<212>  DNA
<213>  Homo sapiens

<400>  2364
atgggcctga agaggccact ggcaggcggg agctgggcct gccgaagcgg cggagaggcc     60

ggagctttgg actcgggagg ccgcaggcga gagcgagctg ggcgtggaga gtccgctagg    120

ctgccgggag gaagagctgg gcctggagag gccgactgca ggaagtgcag gacctggagc    180

ccatgcaaag gagcaaacgc caggccggga gaggccgccc tgacacatga gcttggcctc    240

cggagggccg tgaggcagga gctgggcctg cgggggccgc cccaaggcgg gagcctggtc    300

cgaggaggcc acggcgaggc aagaggtggg cgtggagggc ccacggttga gaggctgccg    360

ggaggaagag ctgggcctgg agaggccgac tgcaggaagt gcaggacctg gagcccatgc    420

aaaggagcaa acgccaggcc gggagaggcc gccctgacac atgagcttgg cctccggagg    480

gccgtgaggc aggagctggg cctgcggggg ccgccccaag gcgggagcct ggtccgagga    540

ggccacggcg aggcaagagg tgggcgtgga gggcccacgg ttgagaggct gccgggagga    600

agagctgggc ctggagaggc cgactgcagg aagtgcagga cctggagccc atgcaaagga    660

gcaaacgcca ggccgggaga ggccgccctg acacatgagc ttggcctccg gagggccgtg    720

aggcaggagc tgggcctgcg ggggccgccc caaggcggga gcctggtccg aggaggccac    780

ggcgaggcaa gaggtgggcg tggagggccc acggttgaga ggctgccggg aggaagagct    840

gggcctggag aggccgactg caggaagtgc aggacctgga gcccatgcaa aggagcaaac    900

gccaggccgg gagaggccgc cctgacacat gagcttggcc tccggagggc cgtgaggcag    960

gagctgggcc tgcgggggcc gccccaaggc gggagcctgg tccgaggagg ccacggcgag   1020

gcaagaggtg ggcgtggagg gcccacggtt gaggtagagg ctgggcctct agaggccgcc   1080

aacaggcagg ggctgggcct ggagaagcca acagaggcat ga                      1122


<210>  2365
<211>  373
<212>  PRT
<213>  Homo sapiens

<400>  2365


Met Gly Leu Lys Arg Pro Leu Ala Gly Gly Ser Trp Ala Cys Arg Ser 
1               5                   10                  15      


Gly Gly Glu Ala Gly Ala Leu Asp Ser Gly Gly Arg Arg Arg Glu Arg 
            20                  25                  30          


Ala Gly Arg Gly Glu Ser Ala Arg Leu Pro Gly Gly Arg Ala Gly Pro 
        35                  40                  45              


Gly Glu Ala Asp Cys Arg Lys Cys Arg Thr Trp Ser Pro Cys Lys Gly 
    50                  55                  60                  


Ala Asn Ala Arg Pro Gly Glu Ala Ala Leu Thr His Glu Leu Gly Leu 
65                  70                  75                  80  


Arg Arg Ala Val Arg Gln Glu Leu Gly Leu Arg Gly Pro Pro Gln Gly 
                85                  90                  95      


Gly Ser Leu Val Arg Gly Gly His Gly Glu Ala Arg Gly Gly Arg Gly 
            100                 105                 110         


Gly Pro Thr Val Glu Arg Leu Pro Gly Gly Arg Ala Gly Pro Gly Glu 
        115                 120                 125             


Ala Asp Cys Arg Lys Cys Arg Thr Trp Ser Pro Cys Lys Gly Ala Asn 
    130                 135                 140                 


Ala Arg Pro Gly Glu Ala Ala Leu Thr His Glu Leu Gly Leu Arg Arg 
145                 150                 155                 160 


Ala Val Arg Gln Glu Leu Gly Leu Arg Gly Pro Pro Gln Gly Gly Ser 
                165                 170                 175     


Leu Val Arg Gly Gly His Gly Glu Ala Arg Gly Gly Arg Gly Gly Pro 
            180                 185                 190         


Thr Val Glu Arg Leu Pro Gly Gly Arg Ala Gly Pro Gly Glu Ala Asp 
        195                 200                 205             


Cys Arg Lys Cys Arg Thr Trp Ser Pro Cys Lys Gly Ala Asn Ala Arg 
    210                 215                 220                 


Pro Gly Glu Ala Ala Leu Thr His Glu Leu Gly Leu Arg Arg Ala Val 
225                 230                 235                 240 


Arg Gln Glu Leu Gly Leu Arg Gly Pro Pro Gln Gly Gly Ser Leu Val 
                245                 250                 255     


Arg Gly Gly His Gly Glu Ala Arg Gly Gly Arg Gly Gly Pro Thr Val 
            260                 265                 270         


Glu Arg Leu Pro Gly Gly Arg Ala Gly Pro Gly Glu Ala Asp Cys Arg 
        275                 280                 285             


Lys Cys Arg Thr Trp Ser Pro Cys Lys Gly Ala Asn Ala Arg Pro Gly 
    290                 295                 300                 


Glu Ala Ala Leu Thr His Glu Leu Gly Leu Arg Arg Ala Val Arg Gln 
305                 310                 315                 320 


Glu Leu Gly Leu Arg Gly Pro Pro Gln Gly Gly Ser Leu Val Arg Gly 
                325                 330                 335     


Gly His Gly Glu Ala Arg Gly Gly Arg Gly Gly Pro Thr Val Glu Val 
            340                 345                 350         


Glu Ala Gly Pro Leu Glu Ala Ala Asn Arg Gln Gly Leu Gly Leu Glu 
        355                 360                 365             


Lys Pro Thr Glu Ala 
    370             

<210>  2366
<211>  1227
<212>  DNA
<213>  Homo sapiens

<400>  2366
atggcgactt ttccaggcac agcttttgcc ttttgcagcc tgtccaggcc cagaatgtgc     60

ttaactcggc atcgccagga caagctcatc ctcccggccc agtttttccc ttccggcggc    120

ctctccgggc ccagaagctc ctcaagtcag cctctccaga cacacttgca gcctcccggc    180

gtcctctccg ggcccagctc ttcctcccgg cagcctctgc aggaccagac tgttgtcaag    240

cccgactcct gcctcccaac aacctctttg gactcagtgc ctgcccagct cctggtggcc    300

ttggtcggcc cacagcttcc tgaagccaag ctccccgggc ccagctcagg cctcacggtg    360

gcctctccag gctcacctcc tgccctccga cggcgtctcc aggccccaaa tggcctcggg    420

tcgaggccca gcctctacct caagagtggg ccctccacgc ccacctcttg cctcgccgtg    480

gcctcctcgg accaggctcc cgccttgggg cggcccccgc aggcccagct cctgcctcac    540

ggccctccgg aggccaagct catgcgtcag ggcggcctct cccggcctgg cgtttgctcc    600

tttgcatggg ctccaggtcc tgcacttcct ccagtcggcc tctccaggcc cagctcttcc    660

tcccggcagc ctctgcggga ccagactgtc gtcaatgggc cctccacgcc cacctgttgc    720

cttgccgtgg cgtcctcggg ccaggctccc gccttggggc ggcccccgca ggcccagctc    780

ctgcctcacg gccctccgga ggccaagctc atgcgtcaga gcggcctctc ccggcctggc    840

gtttgctcct ttgcatgggc tccaggtcct gcacttcctc cagtcggcct ctccaggccc    900

agcgcttcct cccggcagcc tctgcaggac cagactgtcg tcaagtaggc ctgtccaggg    960

acagctcctg cctcccggca gactctgcag gcccaagtcg tcctcaagtc agcctcccca   1020

ggcccagctc cggcctctcg gcggcctctc caggtgcaaa agttcctcga gtccgtctct   1080

ccaggtccag ctcctcctgt ctcccagtgg cctctttcag cccagcccag ctcatgcctc   1140

ccggcgacct tcccaggccc cgcttttgac tttccgcgac ctctgcaggc cccgaaattg   1200

acctccagtc ggcctctgca ggcctgg                                       1227


<210>  2367
<211>  315
<212>  PRT
<213>  Homo sapiens

<400>  2367


Met Ala Thr Phe Pro Gly Thr Ala Phe Ala Phe Cys Ser Leu Ser Arg 
1               5                   10                  15      


Pro Arg Met Cys Leu Thr Arg His Arg Gln Asp Lys Leu Ile Leu Pro 
            20                  25                  30          


Ala Gln Phe Phe Pro Ser Gly Gly Leu Ser Gly Pro Arg Ser Ser Ser 
        35                  40                  45              


Ser Gln Pro Leu Gln Thr His Leu Gln Pro Pro Gly Val Leu Ser Gly 
    50                  55                  60                  


Pro Ser Ser Ser Ser Arg Gln Pro Leu Gln Asp Gln Thr Val Val Lys 
65                  70                  75                  80  


Pro Asp Ser Cys Leu Pro Thr Thr Ser Leu Asp Ser Val Pro Ala Gln 
                85                  90                  95      


Leu Leu Val Ala Leu Val Gly Pro Gln Leu Pro Glu Ala Lys Leu Pro 
            100                 105                 110         


Gly Pro Ser Ser Gly Leu Thr Val Ala Ser Pro Gly Ser Pro Pro Ala 
        115                 120                 125             


Leu Arg Arg Arg Leu Gln Ala Pro Asn Gly Leu Gly Ser Arg Pro Ser 
    130                 135                 140                 


Leu Tyr Leu Lys Ser Gly Pro Ser Thr Pro Thr Ser Cys Leu Ala Val 
145                 150                 155                 160 


Ala Ser Ser Asp Gln Ala Pro Ala Leu Gly Arg Pro Pro Gln Ala Gln 
                165                 170                 175     


Leu Leu Pro His Gly Pro Pro Glu Ala Lys Leu Met Arg Gln Gly Gly 
            180                 185                 190         


Leu Ser Arg Pro Gly Val Cys Ser Phe Ala Trp Ala Pro Gly Pro Ala 
        195                 200                 205             


Leu Pro Pro Val Gly Leu Ser Arg Pro Ser Ser Ser Ser Arg Gln Pro 
    210                 215                 220                 


Leu Arg Asp Gln Thr Val Val Asn Gly Pro Ser Thr Pro Thr Cys Cys 
225                 230                 235                 240 


Leu Ala Val Ala Ser Ser Gly Gln Ala Pro Ala Leu Gly Arg Pro Pro 
                245                 250                 255     


Gln Ala Gln Leu Leu Pro His Gly Pro Pro Glu Ala Lys Leu Met Arg 
            260                 265                 270         


Gln Ser Gly Leu Ser Arg Pro Gly Val Cys Ser Phe Ala Trp Ala Pro 
        275                 280                 285             


Gly Pro Ala Leu Pro Pro Val Gly Leu Ser Arg Pro Ser Ala Ser Ser 
    290                 295                 300                 


Arg Gln Pro Leu Gln Asp Gln Thr Val Val Lys 
305                 310                 315 

<210>  2368
<211>  1157
<212>  DNA
<213>  Homo sapiens

<400>  2368
ggtatggtgg ctcatgcctg tcattccagc acattgaaag gccaaggcgg gtgggtcacc     60

tgagttcagg agttcaagac cagcctgacc aacttggtga aaccccatct ctgctaaaaa    120

cacaaaaatt agccaggtat ggtggcgcat ttctgtaatc ccagctactc aggaggctga    180

ggcaggagac tcacctgaac ccaggaggtg gaggttgcag tgagtggaga tcacaccact    240

ggactctagc ctgggcagcg agagtaaaac tctgcctcaa aaaaaaagaa aagaaaagaa    300

actcaatcat caatatttag tcactcttaa gactgaccca ggaataacag agcagataaa    360

atccagcaaa ttagacttca ttcaagtact taggtgtact gtgagccacc atggtgcctc    420

taaacaccat ggaggcagtg gtcactattc ttgcactgat gaagatggct gtgtacagga    480

ttggggactt caggggcaat ggaaagtgcc aggactgcag ctcagagcca ggcttttcca    540

tgaaggactt atggccacac ttgtcacctc tagctagaaa aacattttag tagaaatgtc    600

attttattgt tttaattcca gaaatgactt cagtggcaaa tagaacttac ttttttactg    660

ttgttgttgt tgttgttgcg gagtttcact ctgttgccca ggctggagtg cagtgctgtg    720

atctcagttc atagcagcct ctgcctccca gcttcaagtg attctcctgc ttcagcctcc    780

cgagtagctg ggattacagg tgccagccac catgcctggc taattttttg tatttttagt    840

agagatgggg tttcaccatg ttggccaggc tggtctcgaa ctccttacct caggtgatcc    900

acccacctca gcctcccaaa gccgaggtgg gaggatcacc tgaggtcagg agttcaagac    960

cagcctggcc aatatggcga aaccccgtct ctactaaaaa tacaaaaatt aaccgggtgt   1020

ggtggcatgc gcctgtaatc ccagctcctc aggaggctga ggcaggagaa ttgttggagc   1080

acagggggca gaggctgcag tgagccgaga ttagaacatt gcactgcagc ctgggcgaca   1140

gtgcaagact ctgtctc                                                  1157


<210>  2369
<211>  81
<212>  PRT
<213>  Homo sapiens

<400>  2369


Met Leu Ala Arg Leu Val Ser Asn Ser Leu Pro Gln Val Ile His Pro 
1               5                   10                  15      


Pro Gln Pro Pro Lys Ala Glu Val Gly Gly Ser Pro Glu Val Arg Ser 
            20                  25                  30          


Ser Arg Pro Ala Trp Pro Ile Trp Arg Asn Pro Val Ser Thr Lys Asn 
        35                  40                  45              


Thr Lys Ile Asn Arg Val Trp Trp His Ala Pro Val Ile Pro Ala Pro 
    50                  55                  60                  


Gln Glu Ala Glu Ala Gly Glu Leu Leu Glu His Arg Gly Gln Arg Leu 
65                  70                  75                  80  


Gln 
    

<210>  2370
<211>  564
<212>  DNA
<213>  Homo sapiens

<400>  2370
gcttcccagc tacttgaacc ccgcaaggtt caaggctcca atgagctatg atcccaccac     60

aacactccag tctgcgagac tgaggctgga gttgcaatct cagctcacca caacgtccgc    120

ctcccagatt caagagattc tcctgcctca gcctcccaag ttgctgggac tacaggggtg    180

cgtcccacgc ccaggggcat tagcagtatg gtcaggtgct gcatccacaa gcccacgagc    240

caggagcctg ctgtgaaggt catcgacgtc accagtggaa gcagcttcac ccccgaggag    300

gtgcaggagc tgcaagaagc cacactgaag gaggttgaca tcctgcacaa ggtctaaggg    360

caccccagca tcaagccacc cagagttccc ttgctgagga tctgagcatg acccgggatg    420

aggcactgcc ggactctcat tccgcacagg acttccatga caattattag cccaacgaga    480

tcctgggcag tgctgtccac ttgaagaaac ccttggtttg gggtcctgcc ctcctgaagc    540

caggacagat aagagaaacc actc                                           564


<210>  2371
<211>  71
<212>  PRT
<213>  Homo sapiens

<400>  2371


Met Ser Tyr Asp Pro Thr Thr Thr Leu Gln Ser Ala Arg Leu Arg Leu 
1               5                   10                  15      


Glu Leu Gln Ser Gln Leu Thr Thr Thr Ser Ala Ser Gln Ile Gln Glu 
            20                  25                  30          


Ile Leu Leu Pro Gln Pro Pro Lys Leu Leu Gly Leu Gln Gly Cys Val 
        35                  40                  45              


Pro Arg Pro Gly Ala Leu Ala Val Trp Ser Gly Ala Ala Ser Thr Ser 
    50                  55                  60                  


Pro Arg Ala Arg Ser Leu Leu 
65                  70      

<210>  2372
<211>  447
<212>  DNA
<213>  Homo sapiens

<400>  2372
atggacagtg gccatgcatt ggaggagcca gtgcccaatg accgctatca cgccatctac     60

tttgcgatgc tgctgtctgg cgtgggcttc ctgctgccat acaacagctt catcacggac    120

gtggactacc tgcatcacaa gtacccaggg acttccattg tgtttgacat gagcctcacc    180

tacatcttgg tggcgctggc agccgtgctc ctgaacaacg tcctggtgga gagactgacc    240

ctgcacacca ggatcaccgc aagctacctc ttagccttgg gccctctcct ttttatcagc    300

atctgtgacg tgtggctgca gctcttctct cgggaccagg cctacgccat caacctggct    360

gctgtgggca ccgtggcctt cggctgcaca gtgcaaaacc agaatgagca ggtaaatcct    420

ggtgggggtg tgcggcaggc ttcctag                                        447


<210>  2373
<211>  148
<212>  PRT
<213>  Homo sapiens

<400>  2373


Met Asp Ser Gly His Ala Leu Glu Glu Pro Val Pro Asn Asp Arg Tyr 
1               5                   10                  15      


His Ala Ile Tyr Phe Ala Met Leu Leu Ser Gly Val Gly Phe Leu Leu 
            20                  25                  30          


Pro Tyr Asn Ser Phe Ile Thr Asp Val Asp Tyr Leu His His Lys Tyr 
        35                  40                  45              


Pro Gly Thr Ser Ile Val Phe Asp Met Ser Leu Thr Tyr Ile Leu Val 
    50                  55                  60                  


Ala Leu Ala Ala Val Leu Leu Asn Asn Val Leu Val Glu Arg Leu Thr 
65                  70                  75                  80  


Leu His Thr Arg Ile Thr Ala Ser Tyr Leu Leu Ala Leu Gly Pro Leu 
                85                  90                  95      


Leu Phe Ile Ser Ile Cys Asp Val Trp Leu Gln Leu Phe Ser Arg Asp 
            100                 105                 110         


Gln Ala Tyr Ala Ile Asn Leu Ala Ala Val Gly Thr Val Ala Phe Gly 
        115                 120                 125             


Cys Thr Val Gln Asn Gln Asn Glu Gln Val Asn Pro Gly Gly Gly Val 
    130                 135                 140                 


Arg Gln Ala Ser 
145             

<210>  2374
<211>  684
<212>  DNA
<213>  Homo sapiens

<400>  2374
gtgtatgccg ggcagacgct gatgccacgg ggagaggcct tagaaggagc ataggaaagt     60

cccaggtaag aactagcaca ggctgccatg ggctctgtcg ggagccagtg ccttgaggag    120

cccagtgtgg caggcacacc agacccgggc atagtgatga gcgtcacctt cgacagtcac    180

cagctggagg aggcggcgga ggcggctcag ggccagggcc ttagggccag gggcgtccca    240

gctttcacgg ataccacatt ggaggagcca gtgcccaatg accgctatca cgccatctac    300

tttgcgatgc tgctgtctgg cgtgggcttc ctgctgccat acaacagctt catcacggac    360

gtggactacc tgcatcacaa gtacccaggg acttccattg tgtttgacat gagcctcacc    420

tacatcttgg tggcgctggc agccgtgctc ctgaacaacg tcctggtgga gagactgacc    480

ctgcacacca ggatcaccgc aagctacctc ttagccttgg gccctctcct ttttatcagc    540

atctgtgacg tgtggctgca gctcttctct cgggaccagg cctacgccat caacctggct    600

gctgtgggca ccgtggcctt cggctgcaca gtgcaaaacc agaatgagca ggtaaatgct    660

ccagcacggc agatcatggc ttag                                           684


<210>  2375
<211>  198
<212>  PRT
<213>  Homo sapiens

<400>  2375


Met Gly Ser Val Gly Ser Gln Cys Leu Glu Glu Pro Ser Val Ala Gly 
1               5                   10                  15      


Thr Pro Asp Pro Gly Ile Val Met Ser Val Thr Phe Asp Ser His Gln 
            20                  25                  30          


Leu Glu Glu Ala Ala Glu Ala Ala Gln Gly Gln Gly Leu Arg Ala Arg 
        35                  40                  45              


Gly Val Pro Ala Phe Thr Asp Thr Thr Leu Glu Glu Pro Val Pro Asn 
    50                  55                  60                  


Asp Arg Tyr His Ala Ile Tyr Phe Ala Met Leu Leu Ser Gly Val Gly 
65                  70                  75                  80  


Phe Leu Leu Pro Tyr Asn Ser Phe Ile Thr Asp Val Asp Tyr Leu His 
                85                  90                  95      


His Lys Tyr Pro Gly Thr Ser Ile Val Phe Asp Met Ser Leu Thr Tyr 
            100                 105                 110         


Ile Leu Val Ala Leu Ala Ala Val Leu Leu Asn Asn Val Leu Val Glu 
        115                 120                 125             


Arg Leu Thr Leu His Thr Arg Ile Thr Ala Ser Tyr Leu Leu Ala Leu 
    130                 135                 140                 


Gly Pro Leu Leu Phe Ile Ser Ile Cys Asp Val Trp Leu Gln Leu Phe 
145                 150                 155                 160 


Ser Arg Asp Gln Ala Tyr Ala Ile Asn Leu Ala Ala Val Gly Thr Val 
                165                 170                 175     


Ala Phe Gly Cys Thr Val Gln Asn Gln Asn Glu Gln Val Asn Ala Pro 
            180                 185                 190         


Ala Arg Gln Ile Met Ala 
        195             

<210>  2376
<211>  1584
<212>  DNA
<213>  Homo sapiens

<400>  2376
atggtggccc cgggagaccc aggtgacctg cggctgaccc agcccaccac ccccgctgcc     60

cacccctcag ccttggtgcc caggccgctc cccctaaaca ggtccactcg cctgggaggc    120

cagcaatgcc gccagtgggg agtggctttc atagaagtca gctcctctca ttcgcacagg    180

gacctgggta ccagtgaacc accttttgca gaccagggag ccagctggcc cctcttcctg    240

aagaccagag agatgagaaa actgatgcca gagggcctga ggccagtgca agattcccag    300

ccgggctcca agggagcaca gagccaagac ctgaaccagg tctgcctggg ccccgagcca    360

ctgtccttcc cacgacccca gcggccattt gccgtggcca ataggatcaa taaaacgcct    420

ggggtatctg gccgctcggt ggaaattgac ccacgcaggg cctttgctgg ccacaccggg    480

ccccttggat ttaataagct ttgggctttc caagagaaag ccttggaaga ggaatttgaa    540

aaacttgcct cagctccaga ctttgcttct cactcactgg gtgaccttga tctgtggctc    600

cgtttctcta cctgcaaaga aaagggcata aagctgtatg agtggcgttt ctgccacttg    660

gaactgaagg agtgtggatg tacctgtttc caggaagagg aatcgatgga tttcatcaaa    720

ttctccttga ttcccccaaa gactaagaag ccctgctatg gtttgaataa gaagaaaggg    780

aaagaggcca tgccaggagc tgggctgctg ccaccccaag ctcccgcctt gccctctgag    840

gccagggctc ctcacggcat ctccctgact gctgccagaa ggagcaaagc caaggccaaa    900

gggaaggagg tgaagaagga gaacctcagc aaggggggcg ctgtgagcaa gctgatggag    960

agcatggcag ccgaggagga ctttgaaccc aaccaagact cgagcttctc tgaggacgag   1020

cacctgccac gtggcggggc tgcggagcgg ccgctgaccc cggcccctcg ctcctgcatc   1080

atcgacaagg acgagctgaa ggacggcctg cgtgtgctca tccccttgga cgacaagctg   1140

ctgtaggctg ggcacgtgca gaccgtgcac tcgccagaca tataccgtgt ggtggtggag   1200

ggtgagcgtg ggaaccagcc ccacatctac tgtctggagg agttgctgca ggaggtgatc   1260

atcgatgtga ggccagctgc cactcgcttc ttgccacaag ggaccaggat tgcagcctac   1320

tggagccagc agtaccgctg tctctaccca ggcaccgtgg tctgagggtt actggacctg   1380

gaggaggatg gggacttgac caccgtggag tctgacaacg gagacacggg caggatcccc   1440

ctctcacata tccgcctcct gccccctgac tataagatcc aatgtgctga gccatccccg   1500

gccctcctgg tgccaagtgc caagcgccgc agccggaaga ccagcaaaga cactggggag   1560

ggcaaagacg gtggcacggc tggg                                          1584


<210>  2377
<211>  381
<212>  PRT
<213>  Homo sapiens

<400>  2377


Met Val Ala Pro Gly Asp Pro Gly Asp Leu Arg Leu Thr Gln Pro Thr 
1               5                   10                  15      


Thr Pro Ala Ala His Pro Ser Ala Leu Val Pro Arg Pro Leu Pro Leu 
            20                  25                  30          


Asn Arg Ser Thr Arg Leu Gly Gly Gln Gln Cys Arg Gln Trp Gly Val 
        35                  40                  45              


Ala Phe Ile Glu Val Ser Ser Ser His Ser His Arg Asp Leu Gly Thr 
    50                  55                  60                  


Ser Glu Pro Pro Phe Ala Asp Gln Gly Ala Ser Trp Pro Leu Phe Leu 
65                  70                  75                  80  


Lys Thr Arg Glu Met Arg Lys Leu Met Pro Glu Gly Leu Arg Pro Val 
                85                  90                  95      


Gln Asp Ser Gln Pro Gly Ser Lys Gly Ala Gln Ser Gln Asp Leu Asn 
            100                 105                 110         


Gln Val Cys Leu Gly Pro Glu Pro Leu Ser Phe Pro Arg Pro Gln Arg 
        115                 120                 125             


Pro Phe Ala Val Ala Asn Arg Ile Asn Lys Thr Pro Gly Val Ser Gly 
    130                 135                 140                 


Arg Ser Val Glu Ile Asp Pro Arg Arg Ala Phe Ala Gly His Thr Gly 
145                 150                 155                 160 


Pro Leu Gly Phe Asn Lys Leu Trp Ala Phe Gln Glu Lys Ala Leu Glu 
                165                 170                 175     


Glu Glu Phe Glu Lys Leu Ala Ser Ala Pro Asp Phe Ala Ser His Ser 
            180                 185                 190         


Leu Gly Asp Leu Asp Leu Trp Leu Arg Phe Ser Thr Cys Lys Glu Lys 
        195                 200                 205             


Gly Ile Lys Leu Tyr Glu Trp Arg Phe Cys His Leu Glu Leu Lys Glu 
    210                 215                 220                 


Cys Gly Cys Thr Cys Phe Gln Glu Glu Glu Ser Met Asp Phe Ile Lys 
225                 230                 235                 240 


Phe Ser Leu Ile Pro Pro Lys Thr Lys Lys Pro Cys Tyr Gly Leu Asn 
                245                 250                 255     


Lys Lys Lys Gly Lys Glu Ala Met Pro Gly Ala Gly Leu Leu Pro Pro 
            260                 265                 270         


Gln Ala Pro Ala Leu Pro Ser Glu Ala Arg Ala Pro His Gly Ile Ser 
        275                 280                 285             


Leu Thr Ala Ala Arg Arg Ser Lys Ala Lys Ala Lys Gly Lys Glu Val 
    290                 295                 300                 


Lys Lys Glu Asn Leu Ser Lys Gly Gly Ala Val Ser Lys Leu Met Glu 
305                 310                 315                 320 


Ser Met Ala Ala Glu Glu Asp Phe Glu Pro Asn Gln Asp Ser Ser Phe 
                325                 330                 335     


Ser Glu Asp Glu His Leu Pro Arg Gly Gly Ala Ala Glu Arg Pro Leu 
            340                 345                 350         


Thr Pro Ala Pro Arg Ser Cys Ile Ile Asp Lys Asp Glu Leu Lys Asp 
        355                 360                 365             


Gly Leu Arg Val Leu Ile Pro Leu Asp Asp Lys Leu Leu 
    370                 375                 380     

<210>  2378
<211>  2401
<212>  DNA
<213>  Homo sapiens

<400>  2378
atgaggagga gacagcagcc acctcctggg gctggacgag tcgctgacct acgctggcga     60

gggccccagt accagataca acacagtgac tctgccacac agaacagctt ccctccaggt    120

gtccacacgg ctactggcca ggaagagcac ccttttttca tctgcaaagt ggggcgatac    180

atcttggttg ctgtcaagat caaagccgtg gtgaccgttg gaaaacagcg aaggagtcgc    240

tgcctcacca gctccacttc tcagacgcag aaacccatca agccacttgg aacctggccc    300

ctggcccttc ctagcactgc gggcgtgatg atctctctga gccgcatcct cacggagcta    360

ctgctgcccg acgagcgcgc cagcatgctc atcttcttcc tggtgtcggt ggcgctggag    420

ctgctgtgct tcctgctgca cctgttagtg cggtgcagtg gcttcgtgct cttctatacc    480

acacggccgc gcgacagccg ccggggcagg ccaggcctgg gcaggggctc tggctaccgc    540

gtgcaccacg acgtcgtcgc cggggacgtc cacttcgagc acccagcccc ggccctggcc    600

cccaacgggt ccccaaagga cagcccagcc catgaggtga ccggcagcgg cggggcctac    660

atgtgctttg acgtactgtg gccaagggtc cagcgcagct ggcccacctt cagagccgtg    720

ttactgcacc gctacgtggt ggcaggggtg atctgggccg acatgctctc catcgccgtg    780

acctacttca tcacgctgtg cctgttcccc gaccttgagt ctgagatctg ccactgcatc    840

ctgggcgagt ggctgcccat cctcatcatg gctgtgttca acctgtcaga cttcgtgggc    900

aagatcctgg cagccctgcc tgtggactgg cggggcaccc acctgctggc ctgctcctgc    960

ctgcgtgtgg tcttcatccc cctcttcacc ctgtgcgtct accccagcgg catgcccgcc   1020

ctccgccacc ccgcctggcc ctgcattttc tcactgctca tgggcatcag caacggctcc   1080

ttcggcagcg tgcccatgat cttggcagca ggcaaagtga gccccaagca gcgggagccg   1140

gcagggaaca ccatgactgt gtcctacgtg tcagggctga cactggggtc cgccgtggcc   1200

tactgcacct acagcctcac ccgcgatgcc cacggcagct gcctgcacgc ctccaccgcc   1260

aatggctcca tcctcacagg cctctgagcc agccccgccc actgccaggg acaccgaggg   1320

cctgaccagg ggccccgagg cctgagggcc cctcccccat ccccacctca gtgcctgcgg   1380

ggccctgagc ctccccctgt gccagcagca ccactccctc agggtctagc catcccccac   1440

cctggactga agttctgcaa agtcctttga ggaccagaac acgtttctgc gacccggggc   1500

tctggccagc actctgttct gtgtttggtc tcatacctgc gtctaccttc tatctgtgtc   1560

cagcggcccc agctccagcc cagccagcac tctgcagggt cacacgcacc atgtcaccac   1620

ccaggacagc agacacccgc cagagtgtgc gtgcccagtg actgcacccc ggccctcatc   1680

acccgctggc actgatcagg gcaccacctg gcccagcctc catcagggac ccctcctcat   1740

gaaccctgga gccctgagag gagaggggca gtcccccacc ttgtcaccct cagggcttcc   1800

ccttctgtcc tcattcttag agactgcttc tcccaaacaa aacacgttag ccatgaagga   1860

gtcggagccc tgggtccgaa tggacccgcc tgcagtctgc gtcagcctct gggaaaccac   1920

agcggtgatg ccagctgggc acgtcaggac ctccccacac acccacgtga tgccacaggt   1980

cgggggatgt gcctgactag ggagccctcc tattgccttc ctggcccggg atagaagagg   2040

ggaggtaagt ctgggggctt cgaagccggg ccccccaccc tggctgaagt cagcttgacc   2100

taggtcttga ccctcatcca gcaagggacc cgacagaccc aagggtccct agaatgtaag   2160

gaggggttgg gggtcactcc agcccgggcc tcccagaaca ccaggcccgt gtgggtggca   2220

ccctgagttc agggaatcct aagggtatcc ttccagagac ggcgtttcca ggggggagga   2280

ccgcccaccc ttccagatcc ccggccccgg ctgtgactgc cctgtttcac ccctgctgtg   2340

tcccgtcacc cgtctgtcca ctaactgtac cacaccagcc attaaaagat gaaggcagac   2400

g                                                                   2401


<210>  2379
<211>  428
<212>  PRT
<213>  Homo sapiens

<400>  2379


Met Arg Arg Arg Gln Gln Pro Pro Pro Gly Ala Gly Arg Val Ala Asp 
1               5                   10                  15      


Leu Arg Trp Arg Gly Pro Gln Tyr Gln Ile Gln His Ser Asp Ser Ala 
            20                  25                  30          


Thr Gln Asn Ser Phe Pro Pro Gly Val His Thr Ala Thr Gly Gln Glu 
        35                  40                  45              


Glu His Pro Phe Phe Ile Cys Lys Val Gly Arg Tyr Ile Leu Val Ala 
    50                  55                  60                  


Val Lys Ile Lys Ala Val Val Thr Val Gly Lys Gln Arg Arg Ser Arg 
65                  70                  75                  80  


Cys Leu Thr Ser Ser Thr Ser Gln Thr Gln Lys Pro Ile Lys Pro Leu 
                85                  90                  95      


Gly Thr Trp Pro Leu Ala Leu Pro Ser Thr Ala Gly Val Met Ile Ser 
            100                 105                 110         


Leu Ser Arg Ile Leu Thr Glu Leu Leu Leu Pro Asp Glu Arg Ala Ser 
        115                 120                 125             


Met Leu Ile Phe Phe Leu Val Ser Val Ala Leu Glu Leu Leu Cys Phe 
    130                 135                 140                 


Leu Leu His Leu Leu Val Arg Cys Ser Gly Phe Val Leu Phe Tyr Thr 
145                 150                 155                 160 


Thr Arg Pro Arg Asp Ser Arg Arg Gly Arg Pro Gly Leu Gly Arg Gly 
                165                 170                 175     


Ser Gly Tyr Arg Val His His Asp Val Val Ala Gly Asp Val His Phe 
            180                 185                 190         


Glu His Pro Ala Pro Ala Leu Ala Pro Asn Gly Ser Pro Lys Asp Ser 
        195                 200                 205             


Pro Ala His Glu Val Thr Gly Ser Gly Gly Ala Tyr Met Cys Phe Asp 
    210                 215                 220                 


Val Leu Trp Pro Arg Val Gln Arg Ser Trp Pro Thr Phe Arg Ala Val 
225                 230                 235                 240 


Leu Leu His Arg Tyr Val Val Ala Gly Val Ile Trp Ala Asp Met Leu 
                245                 250                 255     


Ser Ile Ala Val Thr Tyr Phe Ile Thr Leu Cys Leu Phe Pro Asp Leu 
            260                 265                 270         


Glu Ser Glu Ile Cys His Cys Ile Leu Gly Glu Trp Leu Pro Ile Leu 
        275                 280                 285             


Ile Met Ala Val Phe Asn Leu Ser Asp Phe Val Gly Lys Ile Leu Ala 
    290                 295                 300                 


Ala Leu Pro Val Asp Trp Arg Gly Thr His Leu Leu Ala Cys Ser Cys 
305                 310                 315                 320 


Leu Arg Val Val Phe Ile Pro Leu Phe Thr Leu Cys Val Tyr Pro Ser 
                325                 330                 335     


Gly Met Pro Ala Leu Arg His Pro Ala Trp Pro Cys Ile Phe Ser Leu 
            340                 345                 350         


Leu Met Gly Ile Ser Asn Gly Ser Phe Gly Ser Val Pro Met Ile Leu 
        355                 360                 365             


Ala Ala Gly Lys Val Ser Pro Lys Gln Arg Glu Pro Ala Gly Asn Thr 
    370                 375                 380                 


Met Thr Val Ser Tyr Val Ser Gly Leu Thr Leu Gly Ser Ala Val Ala 
385                 390                 395                 400 


Tyr Cys Thr Tyr Ser Leu Thr Arg Asp Ala His Gly Ser Cys Leu His 
                405                 410                 415     


Ala Ser Thr Ala Asn Gly Ser Ile Leu Thr Gly Leu 
            420                 425             

<210>  2380
<211>  540
<212>  DNA
<213>  Homo sapiens

<400>  2380
atgggtgagt ttaacagata ttttccctta tttcttttag gggaatctgg attgggaaag     60

tcgacattaa tcaactcatt attcctcaca gatttgtatt ctccagagta cccaggtcct    120

tctcatagaa ttaaaaagac tgtacagcgg ggacatgtga cagcacaggg cagcccgtgg    180

gggttatggc ggggtgagaa atcttcctgt ggctgtggaa ttcttgataa ggtggcgaac    240

gtgttgtgca gcggcatcct gagggctgcc cgccctccca ggcgcccagg gcgggcagct    300

attaacagaa gcaaactctt gctgtttatt tatgacagaa cacacatgca ggacttgaaa    360

gatgttacta acaatgtcca ctacgagaac tatggaagca gaaaactggc agctgtgact    420

tatcatggag ttgataacaa caagaataaa gggcagctga ctaagtaagt atatattttt    480

tctccaaaaa aggtattctt tctgtagtca ataatcatat tgtttcattt tcattaaatt    540


<210>  2381
<211>  155
<212>  PRT
<213>  Homo sapiens

<400>  2381


Met Gly Glu Phe Asn Arg Tyr Phe Pro Leu Phe Leu Leu Gly Glu Ser 
1               5                   10                  15      


Gly Leu Gly Lys Ser Thr Leu Ile Asn Ser Leu Phe Leu Thr Asp Leu 
            20                  25                  30          


Tyr Ser Pro Glu Tyr Pro Gly Pro Ser His Arg Ile Lys Lys Thr Val 
        35                  40                  45              


Gln Arg Gly His Val Thr Ala Gln Gly Ser Pro Trp Gly Leu Trp Arg 
    50                  55                  60                  


Gly Glu Lys Ser Ser Cys Gly Cys Gly Ile Leu Asp Lys Val Ala Asn 
65                  70                  75                  80  


Val Leu Cys Ser Gly Ile Leu Arg Ala Ala Arg Pro Pro Arg Arg Pro 
                85                  90                  95      


Gly Arg Ala Ala Ile Asn Arg Ser Lys Leu Leu Leu Phe Ile Tyr Asp 
            100                 105                 110         


Arg Thr His Met Gln Asp Leu Lys Asp Val Thr Asn Asn Val His Tyr 
        115                 120                 125             


Glu Asn Tyr Gly Ser Arg Lys Leu Ala Ala Val Thr Tyr His Gly Val 
    130                 135                 140                 


Asp Asn Asn Lys Asn Lys Gly Gln Leu Thr Lys 
145                 150                 155 

<210>  2382
<211>  1534
<212>  DNA
<213>  Homo sapiens

<400>  2382
gttacgcgtt cccatttcac ccaagacctt cagccagagc agggcatcaa agattcactc     60

caaaaagtaa taccaagaac atatggaaaa tgtggacatg agaaattaca atttaaaaaa    120

tgctgtaaaa gtgtgggtga atatgaggtg cacaagggag gttatagtga agttaaccaa    180

tgtttgtcaa ctacccaaaa caaaatattt cagactcata aatatgtcaa agtctttggt    240

aaattttcaa attccaatag agataaaaca agatatactg gaaataaaca tttcaaatgt    300

aacaaatatg gcaaatcatt ttgcatgctt tcacacctaa atcaacatca ggtaattcat    360

actagggaga agtcctacaa atgcaaagaa tgtggcaaat cctttaactg ctcctcaaac    420

catactacac ataaaataat tcatactgga gagaaaccat atagatgtga ggaatgtggc    480

aaagccttta gctggtctgc aaaccttact agacataaga gaactcatac tggagagaaa    540

ccctacacgt gtgaagaatg tggccaagcc tttaggcgct cctcagcact tactaaccac    600

aagagaattc atactggaga gagaccctac aaatgtgaag aatgtggcaa agcctttagc    660

gtatcctcaa ccctcactga ccacaagaga attcatactg gagagaaacc ctgcaggtgt    720

gaggaatgtg gcaaagcctt tagctggtcc tcaaacctta ctagacataa gagaattcat    780

actagagaga aaccctatgc ctgtgaagaa tgtggccaag cctttagctt atcctcgaac    840

cttatgagac ataggagaat tcatactgga gagaaaccct acacatgtga agaatgtggc    900

caagacttta ggcgctcctc agcacttact atccacaaga gaattcatac tggagagaga    960

ccctacaaat gtgaagagtg tggcaaagtc tttagcttat cctcaaccct cactgaccac   1020

aagagaattc atactggaga gagaccctac aaatgtgaag aatgtggcaa agcctttagc   1080

ttatcctcaa ccctcactga ccacaagaga attcatactg gagagagacc ctacacatgt   1140

gaagaatgtg gcaaagcctt taattgctcc tcaaccctta tgcaacataa gagaattcat   1200

actggagaga aaccctacaa atgtgaagaa tgtgagcaag cttttaagtg gcattcaagt   1260

cttgctaaac ataagataat tcacactgga gagaaaccct acaaatgtga ataatatggc   1320

aaagtccacc ctcaggcctt ataatacata aaataattta cactggaaaa aaacactaca   1380

aatgtagaga atgtggccaa gcctttaacc agttccaaac cttaattgaa tgtaagagaa   1440

ttcatattgg acagaaattt tataaatgta aaaaaatgta acaaagcctt taaccaaccc   1500

tcaaacctta ataaacctaa gagaatttat ttta                               1534


<210>  2383
<211>  329
<212>  PRT
<213>  Homo sapiens

<400>  2383


Met Leu Ser His Leu Asn Gln His Gln Val Ile His Thr Arg Glu Lys 
1               5                   10                  15      


Ser Tyr Lys Cys Lys Glu Cys Gly Lys Ser Phe Asn Cys Ser Ser Asn 
            20                  25                  30          


His Thr Thr His Lys Ile Ile His Thr Gly Glu Lys Pro Tyr Arg Cys 
        35                  40                  45              


Glu Glu Cys Gly Lys Ala Phe Ser Trp Ser Ala Asn Leu Thr Arg His 
    50                  55                  60                  


Lys Arg Thr His Thr Gly Glu Lys Pro Tyr Thr Cys Glu Glu Cys Gly 
65                  70                  75                  80  


Gln Ala Phe Arg Arg Ser Ser Ala Leu Thr Asn His Lys Arg Ile His 
                85                  90                  95      


Thr Gly Glu Arg Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Ser 
            100                 105                 110         


Val Ser Ser Thr Leu Thr Asp His Lys Arg Ile His Thr Gly Glu Lys 
        115                 120                 125             


Pro Cys Arg Cys Glu Glu Cys Gly Lys Ala Phe Ser Trp Ser Ser Asn 
    130                 135                 140                 


Leu Thr Arg His Lys Arg Ile His Thr Arg Glu Lys Pro Tyr Ala Cys 
145                 150                 155                 160 


Glu Glu Cys Gly Gln Ala Phe Ser Leu Ser Ser Asn Leu Met Arg His 
                165                 170                 175     


Arg Arg Ile His Thr Gly Glu Lys Pro Tyr Thr Cys Glu Glu Cys Gly 
            180                 185                 190         


Gln Asp Phe Arg Arg Ser Ser Ala Leu Thr Ile His Lys Arg Ile His 
        195                 200                 205             


Thr Gly Glu Arg Pro Tyr Lys Cys Glu Glu Cys Gly Lys Val Phe Ser 
    210                 215                 220                 


Leu Ser Ser Thr Leu Thr Asp His Lys Arg Ile His Thr Gly Glu Arg 
225                 230                 235                 240 


Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Ser Leu Ser Ser Thr 
                245                 250                 255     


Leu Thr Asp His Lys Arg Ile His Thr Gly Glu Arg Pro Tyr Thr Cys 
            260                 265                 270         


Glu Glu Cys Gly Lys Ala Phe Asn Cys Ser Ser Thr Leu Met Gln His 
        275                 280                 285             


Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Glu 
    290                 295                 300                 


Gln Ala Phe Lys Trp His Ser Ser Leu Ala Lys His Lys Ile Ile His 
305                 310                 315                 320 


Thr Gly Glu Lys Pro Tyr Lys Cys Glu 
                325                 

<210>  2384
<211>  2066
<212>  DNA
<213>  Homo sapiens

<400>  2384
ggcaggaaag aagagtcaca tcacgtaggt gatgggccta gagatatttc acaatgcctt     60

ctgtaattag aacccagaaa aaagagttat atcatttggg ttaaaggtct tgtgatatgt    120

cacaatccca actaagggca ggacccaggc agaaaaggag agtcacttcc tttgatgatt    180

ggtccagaga tacattacaa tttcccctga ggacagctct catgcagaag aggaactgaa    240

tatactgcat ggcccaggta tctgcagatt tatggctaaa agaccaggac cccctggaag    300

ccgagaaatg ggactgttga cattcagaga catagctata gaattctctc tggaggaatg    360

gcaatgcctg gattgtgctc agcggaattt atatagagat gtgatgttag agaactacag    420

aaacctggtc tccctgggta ttgctgtctc taagccagac ttgatcacct gtctggagca    480

aaataaagag tcccagaata taaagagaaa tgagatggta gccaaacacc cagttacgcg    540

ttcccatttc acccaagacc ttcagccaga gcagggcatc aaagattcac tccaaaaagt    600

aataccaaga acatatggaa aatgtggaca tgagaaatta caatttaaaa aatgctgtaa    660

aagtgtgggt gaatatgagg tgcacaaggg aggttatagt gaagttaacc aatgtttgtc    720

aactacccaa aacaaaatat ttcagactca taaatatgtc aaagtctttg gtaaattttc    780

aaattccaat agagataaaa caagatatac tggaaataaa catttcaaat gtaacaaata    840

tggcaaatca ttttgcatgc tttcacacct aaatcaacat caggtaattc atactaggga    900

gaagtcctac aaatgcaaag aatgtggcaa atcctttaac tgctcctcaa accatactac    960

acataaaata attcatactg gagagaaacc atatagatgt gaggaatgtg gcaaagcctt   1020

tagctggtct gcaaacctta ctagacataa gagaactcat actggagaga aaccctacac   1080

gtgtgaagaa tgtggccaag cctttaggcg ctcctcagca cttactaacc acaagagaat   1140

tcatactgga gagagaccct acaaatgtga agaatgtggc aaagccttta gcgtatcctc   1200

aaccctcact gaccacaaga gaattcatac tggagagaaa ccctgcaggt gtgaggaatg   1260

tggcaaagcc tttagctggt cctcaaacct tactagacat aagagaattc atactagaga   1320

gaaaccctat gcctgtgaag aatgtggcca agcctttagc ttatcctcga accttatgag   1380

acataggaga attcatactg gagagaaacc ctacacatgt gaagaatgtg gccaagactt   1440

taggcgctcc tcagcactta ctatccacaa gagaattcat actggagaga gaccctacaa   1500

atgtgaagag tgtggcaaag tctttagctt atcctcaacc ctcactgacc acaagagaat   1560

tcatactgga gagagaccct acaaatgtga agaatgtggc aaagccttta gcttatcctc   1620

aaccctcact gaccacaaga gaattcatac tggagagaga ccctacacat gtgaagaatg   1680

tggcaaagcc tttaattgct cctcaaccct tatgcaacat aagagaattc atactggaga   1740

gaaaccctac aaatgtgaag aatgtgagca agcttttaag tggcattcaa gtcttgctaa   1800

acataagata attcacactg gagagaaacc ctacaaatgt gaataatatg gcaaagtcca   1860

ccctcaggcc ttataataca taaaataatt tacactggaa aaaaacacta caaatgtaga   1920

gaatgtggcc aagcctttaa ccagttccaa accttaattg aatgtaagag aattcatatt   1980

ggacagaaat tttataaatg taaaaaaatg taacaaagcc tttaaccaac cctcaaacct   2040

taataaacct aagagaattt atttta                                        2066


<210>  2385
<211>  524
<212>  PRT
<213>  Homo sapiens

<400>  2385


Met Ala Lys Arg Pro Gly Pro Pro Gly Ser Arg Glu Met Gly Leu Leu 
1               5                   10                  15      


Thr Phe Arg Asp Ile Ala Ile Glu Phe Ser Leu Glu Glu Trp Gln Cys 
            20                  25                  30          


Leu Asp Cys Ala Gln Arg Asn Leu Tyr Arg Asp Val Met Leu Glu Asn 
        35                  40                  45              


Tyr Arg Asn Leu Val Ser Leu Gly Ile Ala Val Ser Lys Pro Asp Leu 
    50                  55                  60                  


Ile Thr Cys Leu Glu Gln Asn Lys Glu Ser Gln Asn Ile Lys Arg Asn 
65                  70                  75                  80  


Glu Met Val Ala Lys His Pro Val Thr Arg Ser His Phe Thr Gln Asp 
                85                  90                  95      


Leu Gln Pro Glu Gln Gly Ile Lys Asp Ser Leu Gln Lys Val Ile Pro 
            100                 105                 110         


Arg Thr Tyr Gly Lys Cys Gly His Glu Lys Leu Gln Phe Lys Lys Cys 
        115                 120                 125             


Cys Lys Ser Val Gly Glu Tyr Glu Val His Lys Gly Gly Tyr Ser Glu 
    130                 135                 140                 


Val Asn Gln Cys Leu Ser Thr Thr Gln Asn Lys Ile Phe Gln Thr His 
145                 150                 155                 160 


Lys Tyr Val Lys Val Phe Gly Lys Phe Ser Asn Ser Asn Arg Asp Lys 
                165                 170                 175     


Thr Arg Tyr Thr Gly Asn Lys His Phe Lys Cys Asn Lys Tyr Gly Lys 
            180                 185                 190         


Ser Phe Cys Met Leu Ser His Leu Asn Gln His Gln Val Ile His Thr 
        195                 200                 205             


Arg Glu Lys Ser Tyr Lys Cys Lys Glu Cys Gly Lys Ser Phe Asn Cys 
    210                 215                 220                 


Ser Ser Asn His Thr Thr His Lys Ile Ile His Thr Gly Glu Lys Pro 
225                 230                 235                 240 


Tyr Arg Cys Glu Glu Cys Gly Lys Ala Phe Ser Trp Ser Ala Asn Leu 
                245                 250                 255     


Thr Arg His Lys Arg Thr His Thr Gly Glu Lys Pro Tyr Thr Cys Glu 
            260                 265                 270         


Glu Cys Gly Gln Ala Phe Arg Arg Ser Ser Ala Leu Thr Asn His Lys 
        275                 280                 285             


Arg Ile His Thr Gly Glu Arg Pro Tyr Lys Cys Glu Glu Cys Gly Lys 
    290                 295                 300                 


Ala Phe Ser Val Ser Ser Thr Leu Thr Asp His Lys Arg Ile His Thr 
305                 310                 315                 320 


Gly Glu Lys Pro Cys Arg Cys Glu Glu Cys Gly Lys Ala Phe Ser Trp 
                325                 330                 335     


Ser Ser Asn Leu Thr Arg His Lys Arg Ile His Thr Arg Glu Lys Pro 
            340                 345                 350         


Tyr Ala Cys Glu Glu Cys Gly Gln Ala Phe Ser Leu Ser Ser Asn Leu 
        355                 360                 365             


Met Arg His Arg Arg Ile His Thr Gly Glu Lys Pro Tyr Thr Cys Glu 
    370                 375                 380                 


Glu Cys Gly Gln Asp Phe Arg Arg Ser Ser Ala Leu Thr Ile His Lys 
385                 390                 395                 400 


Arg Ile His Thr Gly Glu Arg Pro Tyr Lys Cys Glu Glu Cys Gly Lys 
                405                 410                 415     


Val Phe Ser Leu Ser Ser Thr Leu Thr Asp His Lys Arg Ile His Thr 
            420                 425                 430         


Gly Glu Arg Pro Tyr Lys Cys Glu Glu Cys Gly Lys Ala Phe Ser Leu 
        435                 440                 445             


Ser Ser Thr Leu Thr Asp His Lys Arg Ile His Thr Gly Glu Arg Pro 
    450                 455                 460                 


Tyr Thr Cys Glu Glu Cys Gly Lys Ala Phe Asn Cys Ser Ser Thr Leu 
465                 470                 475                 480 


Met Gln His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu 
                485                 490                 495     


Glu Cys Glu Gln Ala Phe Lys Trp His Ser Ser Leu Ala Lys His Lys 
            500                 505                 510         


Ile Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu 
        515                 520                 

<210>  2386
<211>  486
<212>  DNA
<213>  Homo sapiens

<400>  2386
agccctcaaa tgctacaaag agtgccaaaa tagagcccag ctaaaactgt ggtaaaactg     60

tggctgttgt atgcaaactc aaataaaact ggatccaggt atgagagtca tcatctcacc    120

tgtgagctgt gaccatgtat atgtcgcaat ttcacctgtc atcaggaagc agacatgaga    180

gtcctatcac ctgggtgctg gacgaagttt cgctcttgtt tcccaggccg gagcacaatg    240

gtgtgatctc gactcactgc aacctccgcc tcccggattc aagcgattct cctgcctcag    300

cctgccgagt agctgggatt acagatgaaa aaagatgcaa agaagacata tttgcttttt    360

atccacacat catttccaat cactatgctg agcaaagtca atgtgagcag agctgagaat    420

agcagttttc tggcaggacg gccacttctg agcaaaaaat gacacaataa aagtataaat    480

atttaa                                                               486


<210>  2387
<211>  93
<212>  PRT
<213>  Homo sapiens

<400>  2387


Met Tyr Met Ser Gln Phe His Leu Ser Ser Gly Ser Arg His Glu Ser 
1               5                   10                  15      


Pro Ile Thr Trp Val Leu Asp Glu Val Ser Leu Leu Phe Pro Arg Pro 
            20                  25                  30          


Glu His Asn Gly Val Ile Ser Thr His Cys Asn Leu Arg Leu Pro Asp 
        35                  40                  45              


Ser Ser Asp Ser Pro Ala Ser Ala Cys Arg Val Ala Gly Ile Thr Asp 
    50                  55                  60                  


Glu Lys Arg Cys Lys Glu Asp Ile Phe Ala Phe Tyr Pro His Ile Ile 
65                  70                  75                  80  


Ser Asn His Tyr Ala Glu Gln Ser Gln Cys Glu Gln Ser 
                85                  90              

<210>  2388
<211>  478
<212>  DNA
<213>  Homo sapiens

<400>  2388
aattctatca gatggatgtg catatgagag tcacaatctc accttcgttc tgggtcctgt     60

tatgacactg tatcatttga gggctttata caatatgcct tgatatcata atacactatg    120

acctttattt aagtaggaga cccaggacct tatctgttgc cctaagccta gatatcagag    180

tcaaaatctg ttctcttagc tggatccagg tatgagagtc atcatctcac ctgtgagctg    240

tgaccatgta tatgtcgcaa tttcacctgt catcaggaag cagacatgag agtcctatca    300

cctgggtgct ggatgaaaaa agatgcaaag aagacatatt tgctttttat ccacacatca    360

tttccaatca ctatgctgag caaagtcaat gtgagcagag ctgagaatag cagttttctg    420

gcaggacggc cacttctgag caaaaaatga cacaataaaa gtataaatat ttaatagt      478


<210>  2389
<211>  54
<212>  PRT
<213>  Homo sapiens

<400>  2389


Met Arg Val Leu Ser Pro Gly Cys Trp Met Lys Lys Asp Ala Lys Lys 
1               5                   10                  15      


Thr Tyr Leu Leu Phe Ile His Thr Ser Phe Pro Ile Thr Met Leu Ser 
            20                  25                  30          


Lys Val Asn Val Ser Arg Ala Glu Asn Ser Ser Phe Leu Ala Gly Arg 
        35                  40                  45              


Pro Leu Leu Ser Lys Lys 
    50                  

<210>  2390
<211>  387
<212>  DNA
<213>  Homo sapiens

<400>  2390
atgttaatct ttcaatgtga tgaatgtggc aaagctttta actggtgctt aatctttatt     60

caacataaga gaattaatac aggagagaaa ccatacaaat gtgaggaatg tggaaaagcc    120

tttaactggt tttcaaacct tattcgaaat aagagaattc gtactgtaga gaaactctac    180

aaatgtgaag aatgtgccga aggcttcaac cagggctcac atctcactga acgcaagaga    240

actcatactg gaaggaaatc ctacacatgt gaagaatgtg gcaaaacttt taactggttc    300

tcatactttt ctcaacataa gaggattcat actggagaga aaccatacaa ctgtgaagaa    360

tgtgaaaaag cttttatgca tggctga                                        387


<210>  2391
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  2391


Met Leu Ile Phe Gln Cys Asp Glu Cys Gly Lys Ala Phe Asn Trp Cys 
1               5                   10                  15      


Leu Ile Phe Ile Gln His Lys Arg Ile Asn Thr Gly Glu Lys Pro Tyr 
            20                  25                  30          


Lys Cys Glu Glu Cys Gly Lys Ala Phe Asn Trp Phe Ser Asn Leu Ile 
        35                  40                  45              


Arg Asn Lys Arg Ile Arg Thr Val Glu Lys Leu Tyr Lys Cys Glu Glu 
    50                  55                  60                  


Cys Ala Glu Gly Phe Asn Gln Gly Ser His Leu Thr Glu Arg Lys Arg 
65                  70                  75                  80  


Thr His Thr Gly Arg Lys Ser Tyr Thr Cys Glu Glu Cys Gly Lys Thr 
                85                  90                  95      


Phe Asn Trp Phe Ser Tyr Phe Ser Gln His Lys Arg Ile His Thr Gly 
            100                 105                 110         


Glu Lys Pro Tyr Asn Cys Glu Glu Cys Glu Lys Ala Phe Met His Gly 
        115                 120                 125             

<210>  2392
<211>  643
<212>  DNA
<213>  Homo sapiens

<400>  2392
agtttctcta cagtacgaat tctcttattt cgaataaggt ttgaaaacca gttaaaggct     60

tttccacatt cctcacattt gtatggtttc tctcctgtat taattctctt atgttgaata    120

aagattaagc accagttaaa agctttgcca cattcatcac attgaaagat taacattggt    180

taagtccact ataacttttt tctgtcccgt acactaaccc acgcttttcc agtcttttaa    240

ctttaaattt tcaatgccat agctttcata tcttctcatt atcacttttg ggaataaatg    300

ttttatgctc tgcccaggca aaaggtctgg agtaaaatga gaggacacag cagaagccct    360

caccactgtc atgctccaca ccggtggtga tggtgatgtc atcgatgtag gtggtgggtg    420

tcgtgtacag aagcacagac cactgcagtc ccgcgtagtt gaagaagtca gtctgtgttc    480

tggacaaaac aacccttggg ataccacgat atcataggag tgggcactgc caatcctcag    540

caccactctt gcacgcaggt cctgggtcca tttctccggc agggtcacct cccattcgta    600

caacatccag ctaacaaaat gccgcaggcg ccagtcctgg cca                      643


<210>  2393
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  2393


Met Leu His Thr Gly Gly Asp Gly Asp Val Ile Asp Val Gly Gly Gly 
1               5                   10                  15      


Cys Arg Val Gln Lys His Arg Pro Leu Gln Ser Arg Val Val Glu Glu 
            20                  25                  30          


Val Ser Leu Cys Ser Gly Gln Asn Asn Pro Trp Asp Thr Thr Ile Ser 
        35                  40                  45              

<210>  2394
<211>  6431
<212>  DNA
<213>  Homo sapiens

<400>  2394
gcagtgcccg ggctcccgct gcagccgccc ggggacacgc cgtgcaccct ccggctcggg     60

gctttctcgg cggcggcggc ggcagcagca gcagcgttag cggcggcggc gagagcagcg    120

ttcccggctg cgcttctccc tcaggcgggg cggcgagaga agcggcggcg gcggcggcgg    180

cacaccggtg tctctcccgc tggagatttc tttctgcttt cctcatcgac tgactgactc    240

accccctccc ttttttgagg aagggtgacc tcttctctgg gactggaaaa aatatttttg    300

tgaggagggg ggcgggtggc agcgacaggg tttgcttctt ctcttctttc atctccctct    360

cctcccccct cgaagaccga aaagcaaacc ccacaactgc tccagcagca tcctccttcc    420

cttcctccgc ctcccttctc ctccgccgct cgcagtttcg ccctctcttc cgctaatgat    480

tgcattatta tgctcccctc tctggggggt ctcgcccctc ttgggtcgct ccggagcccc    540

ggcctcccct ggctgcattt cttaaaaatt tgggagcctg ggagtgagtt ttctccgagg    600

cgtgtgtgag aggcggcggg ggtgttttcc tgcgcgaggg gcgggtgaag ttcattgccc    660

ccacttttcc cgcgaccttt ttcggacccg attttggatc gagttgaggg gggcgcgggc    720

gttttcgggg ggcggggggc gcggcggaga atggccgcgg ggagggctcc ccggagcctc    780

ccagtctctt gatcaaagca ttccgctatt ctgatttatt gcttgcttgg tgagttattt    840

ttttttcctc taaaggagac ctgtgtgttc agccattact ttgctcggcg ctgctcccag    900

gcatctccga ccctcggtgc tgtggggagc cccacacttg ggtcggggcg gagggaagcc    960

gtgaaggggg agggagggct cggtgtcaat ttttttttgt gtggctgcgg ccgtagcctg   1020

tggcgggcaa gcggggagac cccggcgcag cagaaccatg gatggcccga cgcggggcca   1080

tggactccgc aaaaagcggc ggtcgcggtc gcagcgagac cgggagaggc gctcccgggg   1140

cgggctgggg gccggcgcgg ccggcggcgg cggggctggc cggacccggg cgctctcact   1200

cgcctcgtcg tcgggctccg acaaggaaga caatgggaag cccccgtcct ccgccccgtc   1260

ccggcccaga cccccgcgga ggaagcggag agagtccacc tcggcagaag aggacatcat   1320

tgatggattt gccatgacca gctttgtcac ttttgaagcg ctggagaaag atgtagcact   1380

taagcctcag gaacgtgtgg agaaacgcca gacgcccctg accaagaaga aacgagaagc   1440

acttaccaat ggcttgtcct ttcattcaaa gaagagcaga ctcagccacc cacaccacta   1500

cagctcagat cgagaaaatg accgcaatct ctgccagcac cttgggaaga gaaagaaaat   1560

gccgaaggca ctcagacagc tcaagccagg acagaacagc tgcagggaca gtgacagtga   1620

aagtgccagt ggagaatcca agggcttcca ccggagcagc tctcgggaaa ggctcagtga   1680

tagttcagct ccttccagct tgggaacagg ctacttcaga tccggagtta ggtgttggca   1740

cgctaccaga acatgacagc caggatgcag ggccgattgt ccccaagata tcgggtctag   1800

agagaagcca ggagaagagc caggactgtt gcaaagagcc aatctttgag cctgtggtgc   1860

ttaaagaccc ctgccctcag gtcgcacagc caatacccca gccgcagacg gagccccaac   1920

tccgagctcc ttctccggac cctgacttgg tgcagcgcac agaggcccca cctcaacccc   1980

cacctctgag tacacagcca ccacagggcc ctcctgaggc ccagctccag cctgccccgc   2040

agcctcaggt gcagaggcca cccaggccac agtcccccac ccagctgctc catcagaacc   2100

tcccacctgt gcaggcccac ccctctgctc agagcctctc ccagccattg tcagcctaca   2160

acagcagtag cttaagcctc aacagtttaa gcagcagcag aagcagcact ccagcgaaga   2220

atatgtttgc ccctcccact gctctgcctc ctccaccacc actgacatca ggaagtctgc   2280

aggtggccgg acacccggcc gggagcactt actcagagca agacatcttg cgacaggaac   2340

tgaacactcg ttttttggcc tctcagagtg ctgaccgcgg ggcttccctg ggccctccgc   2400

cctacctgcg gaccgagttc catcagcacc agcaccagca ccagcacacc caccagcaca   2460

cgcaccagca caccttcacg ccgttccccc acgccatccc acccaccgcc atcatgccga   2520

cgccagcacc tcccatgttt gacaaatacc ctacaaaagt tgacccattc taccggcaca   2580

gtctcttcca ttcctatcct cctgcagtgt cgggcatccc ccctatgatc ccacccactg   2640

gcccttttgg ttcactacaa ggagcatttc agccgaagtt gacagatcct ttcagaccta   2700

tgttaaggaa accagggaag tggtgtgcta tgcatgttca catcgcctgg cagatttacc   2760

accaccaaca gaaagtcaag aaacagatgc agtcagaccc acataagctg gactttggac   2820

tgaaacctga gttcctgagc cgccctccag gccccagtct ttttggagcc atccaccacc   2880

cccatgacct ggcacggcct tcaactttgt tctctgccgc tggtgctgca cacccaactg   2940

ggaccccttt tgggccacct cctcatcaca gcaacttcct caaccctgct gcccacctag   3000

agccttttaa tcggccgtct acattcacag gcctagcagc agttggtggc aatgccttcg   3060

ggggacttgg aaatccttcc gttacaccca actcaatgtt cggccacaag gatggcccca   3120

gtgtgcagaa ctttagcaac cctcacgaac cctggaaccg gctgcaccga acgcctccgt   3180

cgttcccgac ccctccgccc tggctgaagc caggggagct ggagcgcagc gcgtccgctg   3240

cagctcatga cagagataga gatgtagata aacgagactc atctgttagt aaagatgaca   3300

aagaaaggga aagcgtcgag aagagacact ccagccaccc ttcaccagca cctgtcctcc   3360

cggtgaatgc cctgggacat acccgcagct ccactgaaca gatccgggct catctgaaca   3420

ctgaggctcg ggagaaggac aaacccaaag agagggagag agaccactcg gaatcccgca   3480

aggacctggc cgccgacgag cacaaggcga aagagggcca cctgcccgag aaggacgggc   3540

acggccacga ggggcgcgcc gcgggcgaag aggccaagca gctggcccgg gtgccgtctc   3600

cctacgtgcg gaccccggtg gtggagagtg ccaggcccaa cagcacctcg agccgggagg   3660

ccgagccgcg caagggtgag ccggcctacg agaaccccaa gaagagctcc gaggtcaagg   3720

tgaaggagga gcggaaggaa gaccatgacc tgcctccaga ggccccgcag acccaccggg   3780

cctcggagcc gccgcctccc aactcctcgt ccagcgtgca cccggggccc ctggcctcga   3840

tgcccatgac ggtgggggtg acgggcattc accccatgaa cagcatcagc agcctggaca   3900

ggactcgcat gatgaccccc ttcatgggca tcagccccct cccgggcgga gagcgcttcc   3960

cgtacccttc tttccactgg gaccccatcc gggacccctt gagggatcct taccgagaac   4020

ttgacattca ccggagagac ccgctgggca gggacttcct gctaaggaac gacccgctcc   4080

accggctctc gactccccgg ctgtacgaag ccgaccgctc cttcagggac cgggagcctc   4140

acgactacag ccaccaccac caccaccacc accacccgct gtctgtggac cctcggcggg   4200

agcacgagcg gggaggccac ctggacgagc gggagcgctt gcacatgctc agagaagact   4260

acgagcacac gcggctccac tccgtgcacc ccgcctccct cgacggacac ctcccccacc   4320

ccagcctcat caccccggga ctccccagca tgcactatcc ccgcatcagc cccaccgcgg   4380

gcaaccagaa cggactcctc aacaagaccc ctccgacagc agcgctgagc gcacctcccc   4440

cgctcatctc cacgctgggg ggccgcccgg tctctcccag aaggacgact cctctgtccg   4500

cagagataag ggagaggccc ccttcccaca cgctgaagga tatcgaggcc cgataagccg   4560

agaacaggag caagaacgag gaagaagaaa ccctaggcag acaccaggcc aggcttgaga   4620

gacagaactc ctgcatggct cacacagact gggggggaaa gccccacccc ttccccttgt   4680

aaaaaatgta tagactcagt gcacattttg aaatgttttg tatattatat gttgagattt   4740

ttcagatctt ttagcccagt catatgttct cacgtctcct actttttgtt tctcgtataa   4800

aactttttga tttgaaccaa aacagtgaag atgacaacac acaccaattg gatgataatt   4860

gtagcggggg cggtgggggg gagaagtcca cgccatccat catgcaaaat tctttcagat   4920

gaggtgggaa ggccgtgtac atagttatgt aaaaagagat tgcttcatga gctaatggtt   4980

catatatgca aaagggtaag atgaaagctt tactttgtac aaatgtaaat agataaagta   5040

acataataca ttaatacttc ttaaaatgtg ctatttgcaa acttacttaa tatcagtgaa   5100

cacagtcggc taaagctgtg ttcccatata ttgttataga cagctaaacc cttcaactat   5160

gcaatgaatg ttcgggcttt tcacaaaagc ccgcctaact caaaggagcc ttttcaaatc   5220

catttacagc atacttaagg tcatattttc cctgaacaag cgcttacgtg atatgactct   5280

gttttccttg cttgtttttt ttcaaacgga gaaacatcct gttttgcaaa ttggacccca   5340

ggctggaact tagcatctga agttgccgct tgtgggctct gggggaaagt gtagccccgg   5400

agaggtaact gaggacatga gcaaccagtg ccagggaggg tgggatttgc cagatgccaa   5460

aatcagggga cgggtggtgg tgtctgtcag acacacacag gtcgccagtg acttcacaca   5520

cacctcatgt gagaaccatg ccttttttag tgtgtcctat ttcatacctg tacacacttc   5580

ctcgttttgt aatgagattt acttacaccc aaacagatcc tgaaagaaag cttcaagttt   5640

tctcagatga tggatatgtt ttcactgtat tcaataactg acggatgtaa ggtgcacgtt   5700

tcctgatgtg acgcactgta ttccagctgg tgatcaagtc tgggaacagc cgtaacaggt   5760

caaccttgtg gagccatcgc gagttagagg gtgaaagatg gcagaaaaaa aagtcttgtg   5820

tgtgagtgtg ttttttgagt ttgcatcaat cttaatgtct cttcataata cttttataat   5880

acattaagcc tcttgtctac atatttggag agaatatgac tttactagca gagaaataca   5940

atatatcttg tctactggac tgtaaaatat atgtatgaaa taaaattagt tccatttggt   6000

cttctagtat attaaagtgc tatctgacgt tgttatcctg tttttgcaaa aaaaaaaaaa   6060

aaaaaaagtt aactacagac cattgtttct aataagcaga gagatctatt ttagtagtaa   6120

actgaaggtt tagttgtgag cttcagattt tgtgaactcc agatgttgtg cggtgttttt   6180

tttttttttt aagacaacaa ctaaaaaaaa tgcaaggaat atgtacactg gaactgtagt   6240

ggtagctttc agtattgtaa agagattgtt ctatacggac ctttttgctg tttatcctgt   6300

atgtaataaa gtcctttcta gatcctatgt gaaaagaaaa gtgaagcaac tgaatcttca   6360

gcatgttctc atcggcggag ccttcttgtg taatgtaaac tgtgccatgt tattaaaaaa   6420

tgtgaactaa g                                                        6431


<210>  2395
<211>  1035
<212>  PRT
<213>  Homo sapiens

<400>  2395


Met Ala Cys Pro Phe Ile Gln Arg Arg Ala Asp Ser Ala Thr His Thr 
1               5                   10                  15      


Thr Thr Ala Gln Ile Glu Lys Met Thr Ala Ile Ser Ala Ser Thr Leu 
            20                  25                  30          


Gly Arg Glu Arg Lys Cys Arg Arg His Ser Asp Ser Ser Ser Gln Asp 
        35                  40                  45              


Arg Thr Ala Ala Gly Thr Val Thr Val Lys Val Pro Val Glu Asn Pro 
    50                  55                  60                  


Arg Ala Ser Thr Gly Ala Ala Leu Gly Lys Gly Ser Val Ile Val Gln 
65                  70                  75                  80  


Leu Leu Pro Ala Trp Glu Gln Ala Thr Ser Asp Pro Glu Leu Gly Val 
                85                  90                  95      


Gly Thr Leu Pro Glu His Asp Ser Gln Asp Ala Gly Pro Ile Val Pro 
            100                 105                 110         


Lys Ile Ser Gly Leu Glu Arg Ser Gln Glu Lys Ser Gln Asp Cys Cys 
        115                 120                 125             


Lys Glu Pro Ile Phe Glu Pro Val Val Leu Lys Asp Pro Cys Pro Gln 
    130                 135                 140                 


Val Ala Gln Pro Ile Pro Gln Pro Gln Thr Glu Pro Gln Leu Arg Ala 
145                 150                 155                 160 


Pro Ser Pro Asp Pro Asp Leu Val Gln Arg Thr Glu Ala Pro Pro Gln 
                165                 170                 175     


Pro Pro Pro Leu Ser Thr Gln Pro Pro Gln Gly Pro Pro Glu Ala Gln 
            180                 185                 190         


Leu Gln Pro Ala Pro Gln Pro Gln Val Gln Arg Pro Pro Arg Pro Gln 
        195                 200                 205             


Ser Pro Thr Gln Leu Leu His Gln Asn Leu Pro Pro Val Gln Ala His 
    210                 215                 220                 


Pro Ser Ala Gln Ser Leu Ser Gln Pro Leu Ser Ala Tyr Asn Ser Ser 
225                 230                 235                 240 


Ser Leu Ser Leu Asn Ser Leu Ser Ser Ser Arg Ser Ser Thr Pro Ala 
                245                 250                 255     


Lys Asn Met Phe Ala Pro Pro Thr Ala Leu Pro Pro Pro Pro Pro Leu 
            260                 265                 270         


Thr Ser Gly Ser Leu Gln Val Ala Gly His Pro Ala Gly Ser Thr Tyr 
        275                 280                 285             


Ser Glu Gln Asp Ile Leu Arg Gln Glu Leu Asn Thr Arg Phe Leu Ala 
    290                 295                 300                 


Ser Gln Ser Ala Asp Arg Gly Ala Ser Leu Gly Pro Pro Pro Tyr Leu 
305                 310                 315                 320 


Arg Thr Glu Phe His Gln His Gln His Gln His Gln His Thr His Gln 
                325                 330                 335     


His Thr His Gln His Thr Phe Thr Pro Phe Pro His Ala Ile Pro Pro 
            340                 345                 350         


Thr Ala Ile Met Pro Thr Pro Ala Pro Pro Met Phe Asp Lys Tyr Pro 
        355                 360                 365             


Thr Lys Val Asp Pro Phe Tyr Arg His Ser Leu Phe His Ser Tyr Pro 
    370                 375                 380                 


Pro Ala Val Ser Gly Ile Pro Pro Met Ile Pro Pro Thr Gly Pro Phe 
385                 390                 395                 400 


Gly Ser Leu Gln Gly Ala Phe Gln Pro Lys Leu Thr Asp Pro Phe Arg 
                405                 410                 415     


Pro Met Leu Arg Lys Pro Gly Lys Trp Cys Ala Met His Val His Ile 
            420                 425                 430         


Ala Trp Gln Ile Tyr His His Gln Gln Lys Val Lys Lys Gln Met Gln 
        435                 440                 445             


Ser Asp Pro His Lys Leu Asp Phe Gly Leu Lys Pro Glu Phe Leu Ser 
    450                 455                 460                 


Arg Pro Pro Gly Pro Ser Leu Phe Gly Ala Ile His His Pro His Asp 
465                 470                 475                 480 


Leu Ala Arg Pro Ser Thr Leu Phe Ser Ala Ala Gly Ala Ala His Pro 
                485                 490                 495     


Thr Gly Thr Pro Phe Gly Pro Pro Pro His His Ser Asn Phe Leu Asn 
            500                 505                 510         


Pro Ala Ala His Leu Glu Pro Phe Asn Arg Pro Ser Thr Phe Thr Gly 
        515                 520                 525             


Leu Ala Ala Val Gly Gly Asn Ala Phe Gly Gly Leu Gly Asn Pro Ser 
    530                 535                 540                 


Val Thr Pro Asn Ser Met Phe Gly His Lys Asp Gly Pro Ser Val Gln 
545                 550                 555                 560 


Asn Phe Ser Asn Pro His Glu Pro Trp Asn Arg Leu His Arg Thr Pro 
                565                 570                 575     


Pro Ser Phe Pro Thr Pro Pro Pro Trp Leu Lys Pro Gly Glu Leu Glu 
            580                 585                 590         


Arg Ser Ala Ser Ala Ala Ala His Asp Arg Asp Arg Asp Val Asp Lys 
        595                 600                 605             


Arg Asp Ser Ser Val Ser Lys Asp Asp Lys Glu Arg Glu Ser Val Glu 
    610                 615                 620                 


Lys Arg His Ser Ser His Pro Ser Pro Ala Pro Val Leu Pro Val Asn 
625                 630                 635                 640 


Ala Leu Gly His Thr Arg Ser Ser Thr Glu Gln Ile Arg Ala His Leu 
                645                 650                 655     


Asn Thr Glu Ala Arg Glu Lys Asp Lys Pro Lys Glu Arg Glu Arg Asp 
            660                 665                 670         


His Ser Glu Ser Arg Lys Asp Leu Ala Ala Asp Glu His Lys Ala Lys 
        675                 680                 685             


Glu Gly His Leu Pro Glu Lys Asp Gly His Gly His Glu Gly Arg Ala 
    690                 695                 700                 


Ala Gly Glu Glu Ala Lys Gln Leu Ala Arg Val Pro Ser Pro Tyr Val 
705                 710                 715                 720 


Arg Thr Pro Val Val Glu Ser Ala Arg Pro Asn Ser Thr Ser Ser Arg 
                725                 730                 735     


Glu Ala Glu Pro Arg Lys Gly Glu Pro Ala Tyr Glu Asn Pro Lys Lys 
            740                 745                 750         


Ser Ser Glu Val Lys Val Lys Glu Glu Arg Lys Glu Asp His Asp Leu 
        755                 760                 765             


Pro Pro Glu Ala Pro Gln Thr His Arg Ala Ser Glu Pro Pro Pro Pro 
    770                 775                 780                 


Asn Ser Ser Ser Ser Val His Pro Gly Pro Leu Ala Ser Met Pro Met 
785                 790                 795                 800 


Thr Val Gly Val Thr Gly Ile His Pro Met Asn Ser Ile Ser Ser Leu 
                805                 810                 815     


Asp Arg Thr Arg Met Met Thr Pro Phe Met Gly Ile Ser Pro Leu Pro 
            820                 825                 830         


Gly Gly Glu Arg Phe Pro Tyr Pro Ser Phe His Trp Asp Pro Ile Arg 
        835                 840                 845             


Asp Pro Leu Arg Asp Pro Tyr Arg Glu Leu Asp Ile His Arg Arg Asp 
    850                 855                 860                 


Pro Leu Gly Arg Asp Phe Leu Leu Arg Asn Asp Pro Leu His Arg Leu 
865                 870                 875                 880 


Ser Thr Pro Arg Leu Tyr Glu Ala Asp Arg Ser Phe Arg Asp Arg Glu 
                885                 890                 895     


Pro His Asp Tyr Ser His His His His His His His His Pro Leu Ser 
            900                 905                 910         


Val Asp Pro Arg Arg Glu His Glu Arg Gly Gly His Leu Asp Glu Arg 
        915                 920                 925             


Glu Arg Leu His Met Leu Arg Glu Asp Tyr Glu His Thr Arg Leu His 
    930                 935                 940                 


Ser Val His Pro Ala Ser Leu Asp Gly His Leu Pro His Pro Ser Leu 
945                 950                 955                 960 


Ile Thr Pro Gly Leu Pro Ser Met His Tyr Pro Arg Ile Ser Pro Thr 
                965                 970                 975     


Ala Gly Asn Gln Asn Gly Leu Leu Asn Lys Thr Pro Pro Thr Ala Ala 
            980                 985                 990         


Leu Ser Ala Pro Pro Pro Leu Ile  Ser Thr Leu Gly Gly  Arg Pro Val 
        995                 1000                 1005             


Ser Pro  Arg Arg Thr Thr Pro  Leu Ser Ala Glu Ile  Arg Glu Arg 
    1010                 1015                 1020             


Pro Pro  Ser His Thr Leu Lys  Asp Ile Glu Ala Arg  
    1025                 1030                 1035 

<210>  2396
<211>  6630
<212>  DNA
<213>  Homo sapiens

<400>  2396
gcagtgcccg ggctcccgct gcagccgccc ggggacacgc cgtgcaccct ccggctcggg     60

gctttctcgg cggcggcggc ggcagcagca gcagcgttag cggcggcggc gagagcagcg    120

ttcccggctg cgcttctccc tcaggcgggg cggcgagaga agcggcggcg gcggcggcgg    180

cacaccggtg tctctcccgc tggagatttc tttctgcttt cctcatcgac tgactgactc    240

accccctccc ttttttgagg aagggtgacc tcttctctgg gactggaaaa aatatttttg    300

tgaggagggg ggcgggtggc agcgacaggg tttgcttctt ctcttctttc atctccctct    360

cctcccccct cgaagaccga aaagcaaacc ccacaactgc tccagcagca tcctccttcc    420

cttcctccgc ctcccttctc ctccgccgct cgcagtttcg ccctctcttc cgctaatgat    480

tgcattatta tgctcccctc tctggggggt ctcgcccctc ttgggtcgct ccggagcccc    540

ggcctcccct ggctgcattt cttaaaaatt tgggagcctg ggagtgagtt ttctccgagg    600

cgtgtgtgag aggcggcggg ggtgttttcc tgcgcgaggg gcgggtgaag ttcattgccc    660

ccacttttcc cgcgaccttt ttcggacccg attttggatc gagttgaggg gggcgcgggc    720

gttttcgggg ggcggggggc gcggcggaga atggccgcgg ggagggctcc ccggagcctc    780

ccagtctctt gatcaaagca ttccgctatt ctgatttatt gcttgcttgg tgagttattt    840

ttttttcctc taaaggagac ctgtgtgttc agccattact ttgctcggcg ctgctcccag    900

gcatctccga ccctcggtgc tgtggggagc cccacacttg ggtcggggcg gagggaagcc    960

gtgaaggggg agggagggct cggtgtcaat ttttttttgt gtggctgcgg ccgtagcctg   1020

tggcgggcaa gcggggagac cccggcgcag cagaaccatg gatggcccga cgcggggcca   1080

tggactccgc aaaaagcggc ggtcgcggtc gcagcgagac cgggagaggc gctcccgggg   1140

cgggctgggg gccggcgcgg ccggcggcgg cggggctggc cggacccggg cgctctcact   1200

cgcctcgtcg tcgggctccg acaaggaaga caatgggaag cccccgtcct ccgccccgtc   1260

ccggcccaga cccccgcgga ggaagcggag agagtccacc tcggcagaag aggacatcat   1320

tgatggattt gccatgacca gctttgtcac ttttgaagcg ctggagaaag atgtagcact   1380

taagcctcag gaacgtgtgg agaaacgcca gacgcccctg accaagaaga aacgagaagc   1440

acttaccaat ggcttgtcct ttcattcaaa gaagagcaga ctcagccacc cacaccacta   1500

cagctcagat cgagaaaatg accgcaatct ctgccagcac cttgggaaga gaaagaaaat   1560

gccgaaggca ctcagacagc tcaagccagg acagaacagc tgcagggaca gtgacagtga   1620

aagtgccagt ggagaatcca agggcttcca ccggagcagc tctcgggaaa ggctcagtga   1680

tagttcagct ccttccagct tgggaacagg ctacttcaga tccggagtta ggtgttggca   1740

cgctaccaga acatgacagc caggatgcag ggccgattgt ccccaagata tcgggtctag   1800

agagaagcca ggagaagagc caggactgtt gcaaagagcc aatctttgag cctgtggtgc   1860

ttaaagaccc ctgccctcag gtcgcacagc caatacccca gccgcagacg gagccccaac   1920

tccgagctcc ttctccggac cctgacttgg tgcagcgcac agaggcccca cctcaacccc   1980

cacctctgag tacacagcca ccacagggcc ctcctgaggc ccagctccag cctgccccgc   2040

agcctcaggt gcagaggcca cccaggccac agtcccccac ccagctgctc catcagaacc   2100

tcccacctgt gcaggcccac ccctctgctc agagcctctc ccagccattg tcagcctaca   2160

acagcagtag cttaagcctc aacagtttaa gcagcagcag aagcagcact ccagcgaaga   2220

atatgtttgc ccctcccact gctctgcctc ctccaccacc actgacatca ggaagtctgc   2280

aggtggccgg acacccggcc gggagcactt actcagagca agacatcttg cgacaggaac   2340

tgaacactcg ttttttggcc tctcagagtg ctgaccgcgg ggcttccctg ggccctccgc   2400

cctacctgcg gaccgagttc catcagcacc agcaccagca ccagcacacc caccagcaca   2460

cgcaccagca caccttcacg ccgttccccc acgccatccc acccaccgcc atcatgccga   2520

cgccagcacc tcccatgttt gacaaatacc ctacaaaagt tgacccattc taccggcaca   2580

gtctcttcca ttcctatcct cctgcagtgt cgggcatccc ccctatgatc ccacccactg   2640

gcccttttgg ttcactacaa ggagcatttc agccgaagtt gacagatcct ttcagaccta   2700

tgttaaggaa accagggaag tggtgtgcta tgcatgttca catcgcctgg cagatttacc   2760

accaccaaca gaaagtcaag aaacagatgc agtcagaccc acataagctg gactttggac   2820

tgaaacctga gttcctgagc cgccctccag gccccagtct ttttggagcc atccaccacc   2880

cccatgacct ggcacggcct tcaactttgt tctctgccgc tggtgctgca cacccaactg   2940

ggaccccttt tgggccacct cctcatcaca gcaacttcct caaccctgct gcccacctag   3000

agccttttaa tcggccgtct acattcacag gcctagcagc agttggtggc aatgccttcg   3060

ggggacttgg aaatccttcc gttacaccca actcaatgtt cggccacaag gatggcccca   3120

gtgtgcagaa ctttagcaac cctcacgaac cctggaaccg gctgcaccga acgcctccgt   3180

cgttcccgac ccctccgccc tggctgaagc caggggagct ggagcgcagc gcgtccgctg   3240

cagctcatga cagagataga gatgtagata aacgagactc atctgttagt aaagatgaca   3300

aagaaaggga aagcgtcgag aagagacact ccagccaccc ttcaccagca cctgtcctcc   3360

cggtgaatgc cctgggacat acccgcagct ccactgaaca gatccgggct catctgaaca   3420

ctgaggctcg ggagaaggac aaacccaaag agagggagag agaccactcg gaatcccgca   3480

aggacctggc cgccgacgag cacaaggcga aagagggcca cctgcccgag aaggacgggc   3540

acggccacga ggggcgcgcc gcgggcgaag aggccaagca gctggcccgg gtgccgtctc   3600

cctacgtgcg gaccccggtg gtggagagtg ccaggcccaa cagcacctcg agccgggagg   3660

ccgagccgcg caagggtgag ccggcctacg agaaccccaa gaagagctcc gaggtcaagg   3720

tgaaggagga gcggaaggaa gaccatgacc tgcctccaga ggccccgcag acccaccggg   3780

cctcggagcc gccgcctccc aactcctcgt ccagcgtgca cccggggccc ctggcctcga   3840

tgcccatgac ggtgggggtg acgggcattc accccatgaa cagcatcagc agcctggaca   3900

ggactcgcat gatgaccccc ttcatgggca tcagccccct cccgggcgga gagcgcttcc   3960

cgtacccttc tttccactgg gaccccatcc gggacccctt gagggatcct taccgagaac   4020

ttgacattca ccggagagac ccgctgggca gggacttcct gctaaggaac gacccgctcc   4080

accggctctc gactccccgg ctgtacgaag ccgaccgctc cttcagggac cgggagcctc   4140

acgactacag ccaccaccac caccaccacc accacccgct gtctgtggac cctcggcggg   4200

agcacgagcg gggaggccac ctggacgagc gggagcgctt gcacatgctc agagaagact   4260

acgagcacac gcggctccac tccgtgcacc ccgcctccct cgacggacac ctcccccacc   4320

ccagcctcat caccccggga ctccccagca tgcactatcc ccgcatcagc cccaccgcgg   4380

gcaaccagaa cggactcctc aacaagaccc ctccgacagc agcgctgagc gcacctcccc   4440

cgctcatctc cacgctgggg ggccgcccgg tctctcccag aaggacgact cctctgtccg   4500

cagagataag ggagaggccc ccttcccaca cgctgaagga tatcgaggcc cgataagccg   4560

agaacaggag caagaacgag gaagaagaaa ccctaggcag acaccaggcc aggcttgaga   4620

gacagaactc ctgcatggct cacacagact gggggggaaa gccccacccc ttccccttgt   4680

aaaaaatgta tagactcagt gcacattttg aaatgttttg tatattatat gttgagattt   4740

ttcagatctt ttagcccagt catatgttct cacgtctcct actttttgtt tctcgtataa   4800

aactttttga tttgaaccaa aacagtgaag atgacaacac acaccaattg gatgataatt   4860

gtagcggggg cggtgggggg gagaagtcca cgccatccat catgcaaaat tctttcagat   4920

gaggtgggaa ggccgtgtac atagttatgt aaaaagagat tgcttcatga gctaatggtt   4980

catatatgca aaagggtaag atgaaagctt tactttgtac aaatgtaaat agataaagta   5040

acataataca ttaatacttc ttaaaatgtg ctatttgcaa acttacttaa tatcagtgaa   5100

cacagtcggc taaagctgtg ttcccatata ttgttataga cagctaaacc cttcaactat   5160

gcaatgaatg ttcgggcttt tcacaaaagc ccgcctaact caaaggagcc ttttcaaatc   5220

catttacagc atacttaagg tcatattttc cctgaacaag cgcttacgtg atatgactct   5280

gttttccttg cttgtttttt ttcaaacgga gaaacatcct gttttgcaaa ttggacccca   5340

ggctggaact tagcatctga agttgccgct tgtgggctct gggggaaagt gtagccccgg   5400

agaggtaact gaggacatga gcaaccagtg ccagggaggg tgggatttgc cagatgccaa   5460

aatcagggga cgggtggtgg tgtctgtcag acacacacag gtcgccagtg acttcacaca   5520

cacctcatgt gagaaccatg ccttttttag tgtgtcctat ttcatacctg tacacacttc   5580

ctcgttttgt aatgagattt acttacaccc aaacagatcc tgaaagaaag cttcaagttt   5640

tctcagatga tggatatgtt ttcactgtat tcaataactg acggatgtaa ggtgcacgtt   5700

tcctgatgtg acgcactgta ttccagctgg tgatcaagtc tgggaacagc cgtaacaggt   5760

caaccttgtg gagccatcgc gagttagagg gtgaaagatg gcagaaaaaa aagtcttgtg   5820

tgtgagtgtg ttttttgagt ttgcatcaat cttaatgtct cttcataata cttttataat   5880

acattaagcc tcttgtctac atatttggag agaatatgac tttactagca gagaaataca   5940

atatatcttg tctactggac tgtaaaatat atgtatgaaa taaaattagt tccatttggt   6000

cttctagtat attaaagtgc tatctgacgt tgttatcctg tttttgcaaa aaaaaaaaaa   6060

aaaaaaagtt aactacagac cattgtttct aataagcaga gagatctatt ttagtagtaa   6120

actgaaggtt tagttgtgag cttcagattt tgtgaactcc agatgttgtg cggtgttttt   6180

tttttttttt aagacaacaa ctaaaaaaaa tgcaaggaat atgtacactg gaactgtagt   6240

ggtagctttc agtattgtaa agagattgtt ctatacggac ctttttgctg tttatcctgt   6300

atgtaataaa gtcctttcta gatcctatgt gaaaagaaaa gtgaagcaac tgaatcttca   6360

gcatgttctc atcggcggag ccttcttgtg taatgtaaac tgtgccatgt tattaaaaaa   6420

tgtgaactaa gcttccagct gcttgtttgt gtgaggtgac catcattacc ttagggaaga   6480

agccatacct gtacaagacc gggctcttga aaagaaacac ctcgaaccca gcccgtgtaa   6540

gaacagaagg ctcacctgca gtggctgacc accctaccca actcggttag tgtctcacca   6600

atttgttact ataaacattt gcaccccaca                                    6630


<210>  2397
<211>  1035
<212>  PRT
<213>  Homo sapiens

<400>  2397


Met Ala Cys Pro Phe Ile Gln Arg Arg Ala Asp Ser Ala Thr His Thr 
1               5                   10                  15      


Thr Thr Ala Gln Ile Glu Lys Met Thr Ala Ile Ser Ala Ser Thr Leu 
            20                  25                  30          


Gly Arg Glu Arg Lys Cys Arg Arg His Ser Asp Ser Ser Ser Gln Asp 
        35                  40                  45              


Arg Thr Ala Ala Gly Thr Val Thr Val Lys Val Pro Val Glu Asn Pro 
    50                  55                  60                  


Arg Ala Ser Thr Gly Ala Ala Leu Gly Lys Gly Ser Val Ile Val Gln 
65                  70                  75                  80  


Leu Leu Pro Ala Trp Glu Gln Ala Thr Ser Asp Pro Glu Leu Gly Val 
                85                  90                  95      


Gly Thr Leu Pro Glu His Asp Ser Gln Asp Ala Gly Pro Ile Val Pro 
            100                 105                 110         


Lys Ile Ser Gly Leu Glu Arg Ser Gln Glu Lys Ser Gln Asp Cys Cys 
        115                 120                 125             


Lys Glu Pro Ile Phe Glu Pro Val Val Leu Lys Asp Pro Cys Pro Gln 
    130                 135                 140                 


Val Ala Gln Pro Ile Pro Gln Pro Gln Thr Glu Pro Gln Leu Arg Ala 
145                 150                 155                 160 


Pro Ser Pro Asp Pro Asp Leu Val Gln Arg Thr Glu Ala Pro Pro Gln 
                165                 170                 175     


Pro Pro Pro Leu Ser Thr Gln Pro Pro Gln Gly Pro Pro Glu Ala Gln 
            180                 185                 190         


Leu Gln Pro Ala Pro Gln Pro Gln Val Gln Arg Pro Pro Arg Pro Gln 
        195                 200                 205             


Ser Pro Thr Gln Leu Leu His Gln Asn Leu Pro Pro Val Gln Ala His 
    210                 215                 220                 


Pro Ser Ala Gln Ser Leu Ser Gln Pro Leu Ser Ala Tyr Asn Ser Ser 
225                 230                 235                 240 


Ser Leu Ser Leu Asn Ser Leu Ser Ser Ser Arg Ser Ser Thr Pro Ala 
                245                 250                 255     


Lys Asn Met Phe Ala Pro Pro Thr Ala Leu Pro Pro Pro Pro Pro Leu 
            260                 265                 270         


Thr Ser Gly Ser Leu Gln Val Ala Gly His Pro Ala Gly Ser Thr Tyr 
        275                 280                 285             


Ser Glu Gln Asp Ile Leu Arg Gln Glu Leu Asn Thr Arg Phe Leu Ala 
    290                 295                 300                 


Ser Gln Ser Ala Asp Arg Gly Ala Ser Leu Gly Pro Pro Pro Tyr Leu 
305                 310                 315                 320 


Arg Thr Glu Phe His Gln His Gln His Gln His Gln His Thr His Gln 
                325                 330                 335     


His Thr His Gln His Thr Phe Thr Pro Phe Pro His Ala Ile Pro Pro 
            340                 345                 350         


Thr Ala Ile Met Pro Thr Pro Ala Pro Pro Met Phe Asp Lys Tyr Pro 
        355                 360                 365             


Thr Lys Val Asp Pro Phe Tyr Arg His Ser Leu Phe His Ser Tyr Pro 
    370                 375                 380                 


Pro Ala Val Ser Gly Ile Pro Pro Met Ile Pro Pro Thr Gly Pro Phe 
385                 390                 395                 400 


Gly Ser Leu Gln Gly Ala Phe Gln Pro Lys Leu Thr Asp Pro Phe Arg 
                405                 410                 415     


Pro Met Leu Arg Lys Pro Gly Lys Trp Cys Ala Met His Val His Ile 
            420                 425                 430         


Ala Trp Gln Ile Tyr His His Gln Gln Lys Val Lys Lys Gln Met Gln 
        435                 440                 445             


Ser Asp Pro His Lys Leu Asp Phe Gly Leu Lys Pro Glu Phe Leu Ser 
    450                 455                 460                 


Arg Pro Pro Gly Pro Ser Leu Phe Gly Ala Ile His His Pro His Asp 
465                 470                 475                 480 


Leu Ala Arg Pro Ser Thr Leu Phe Ser Ala Ala Gly Ala Ala His Pro 
                485                 490                 495     


Thr Gly Thr Pro Phe Gly Pro Pro Pro His His Ser Asn Phe Leu Asn 
            500                 505                 510         


Pro Ala Ala His Leu Glu Pro Phe Asn Arg Pro Ser Thr Phe Thr Gly 
        515                 520                 525             


Leu Ala Ala Val Gly Gly Asn Ala Phe Gly Gly Leu Gly Asn Pro Ser 
    530                 535                 540                 


Val Thr Pro Asn Ser Met Phe Gly His Lys Asp Gly Pro Ser Val Gln 
545                 550                 555                 560 


Asn Phe Ser Asn Pro His Glu Pro Trp Asn Arg Leu His Arg Thr Pro 
                565                 570                 575     


Pro Ser Phe Pro Thr Pro Pro Pro Trp Leu Lys Pro Gly Glu Leu Glu 
            580                 585                 590         


Arg Ser Ala Ser Ala Ala Ala His Asp Arg Asp Arg Asp Val Asp Lys 
        595                 600                 605             


Arg Asp Ser Ser Val Ser Lys Asp Asp Lys Glu Arg Glu Ser Val Glu 
    610                 615                 620                 


Lys Arg His Ser Ser His Pro Ser Pro Ala Pro Val Leu Pro Val Asn 
625                 630                 635                 640 


Ala Leu Gly His Thr Arg Ser Ser Thr Glu Gln Ile Arg Ala His Leu 
                645                 650                 655     


Asn Thr Glu Ala Arg Glu Lys Asp Lys Pro Lys Glu Arg Glu Arg Asp 
            660                 665                 670         


His Ser Glu Ser Arg Lys Asp Leu Ala Ala Asp Glu His Lys Ala Lys 
        675                 680                 685             


Glu Gly His Leu Pro Glu Lys Asp Gly His Gly His Glu Gly Arg Ala 
    690                 695                 700                 


Ala Gly Glu Glu Ala Lys Gln Leu Ala Arg Val Pro Ser Pro Tyr Val 
705                 710                 715                 720 


Arg Thr Pro Val Val Glu Ser Ala Arg Pro Asn Ser Thr Ser Ser Arg 
                725                 730                 735     


Glu Ala Glu Pro Arg Lys Gly Glu Pro Ala Tyr Glu Asn Pro Lys Lys 
            740                 745                 750         


Ser Ser Glu Val Lys Val Lys Glu Glu Arg Lys Glu Asp His Asp Leu 
        755                 760                 765             


Pro Pro Glu Ala Pro Gln Thr His Arg Ala Ser Glu Pro Pro Pro Pro 
    770                 775                 780                 


Asn Ser Ser Ser Ser Val His Pro Gly Pro Leu Ala Ser Met Pro Met 
785                 790                 795                 800 


Thr Val Gly Val Thr Gly Ile His Pro Met Asn Ser Ile Ser Ser Leu 
                805                 810                 815     


Asp Arg Thr Arg Met Met Thr Pro Phe Met Gly Ile Ser Pro Leu Pro 
            820                 825                 830         


Gly Gly Glu Arg Phe Pro Tyr Pro Ser Phe His Trp Asp Pro Ile Arg 
        835                 840                 845             


Asp Pro Leu Arg Asp Pro Tyr Arg Glu Leu Asp Ile His Arg Arg Asp 
    850                 855                 860                 


Pro Leu Gly Arg Asp Phe Leu Leu Arg Asn Asp Pro Leu His Arg Leu 
865                 870                 875                 880 


Ser Thr Pro Arg Leu Tyr Glu Ala Asp Arg Ser Phe Arg Asp Arg Glu 
                885                 890                 895     


Pro His Asp Tyr Ser His His His His His His His His Pro Leu Ser 
            900                 905                 910         


Val Asp Pro Arg Arg Glu His Glu Arg Gly Gly His Leu Asp Glu Arg 
        915                 920                 925             


Glu Arg Leu His Met Leu Arg Glu Asp Tyr Glu His Thr Arg Leu His 
    930                 935                 940                 


Ser Val His Pro Ala Ser Leu Asp Gly His Leu Pro His Pro Ser Leu 
945                 950                 955                 960 


Ile Thr Pro Gly Leu Pro Ser Met His Tyr Pro Arg Ile Ser Pro Thr 
                965                 970                 975     


Ala Gly Asn Gln Asn Gly Leu Leu Asn Lys Thr Pro Pro Thr Ala Ala 
            980                 985                 990         


Leu Ser Ala Pro Pro Pro Leu Ile  Ser Thr Leu Gly Gly  Arg Pro Val 
        995                 1000                 1005             


Ser Pro  Arg Arg Thr Thr Pro  Leu Ser Ala Glu Ile  Arg Glu Arg 
    1010                 1015                 1020             


Pro Pro  Ser His Thr Leu Lys  Asp Ile Glu Ala Arg  
    1025                 1030                 1035 

<210>  2398
<211>  6390
<212>  DNA
<213>  Homo sapiens

<400>  2398
cgctcgcagt ttcgccctct cttccgctaa tgattgcatt attatgctcc cctctctggg     60

gggtctcgcc cctcttgggt cgctccggag ccccggcctc ccctggctgc atttcttaaa    120

aatttgggag cctgggagtg agttttctcc gaggcgtgtg tgagaggcgg cgggggtgtt    180

ttcctgcgcg aggggcgggt gaagttcatt gcccccactt ttcccgcgac ctttttcgga    240

cccgattttg gatcgagttg aggggggcgc gggcgttttc ggggggcggg gggcgcggcg    300

gagaatggcc gcggggaggg ctccccggag cctcccagtc tcttgatcaa agcattccgc    360

tattctgatt tattgcttgc ttggtgagtt attttttttt cctctaaagg agacctgtgt    420

gttcagccat tactttgctc ggcgctgctc ccaggcatct ccgaccctcg gtgctgtggg    480

gagccccaca cttgggctcc tcgcctctcg ccctcgctcc ccgtccctcc tcccctctct    540

ccgccccttc ccccttttct ttctcctctc tttcttcccc tctctccctt ctttcggccg    600

ccgtctcccc cgcgccctcc tcggggcgga gggaagccgt gaagggggag ggagggctcg    660

gtgtcaattt ttttttgtgt ggctgcggcc gtagcctgtg gcgggcaagc ggggagaccc    720

cggcgcagca gaaccatgga tggcccgacg cggggccatg gactccgcaa aaagcggcgg    780

tcgcggtcgc agcgagaccg ggagaggcgc tcccggggcg ggctgggggc cggcgcggcc    840

ggcggcggcg gggctggccg gacccgggcg ctctcactcg cctcgtcgtc gggctccgac    900

aaggaagaca atgggaagcc cccgtcctcc gccccgtccc ggcccagacc cccgcggagg    960

aagcggagag agtccacctc ggcagaagag gacatcattg atggatttgc catgaccagc   1020

tttgtcactt ttgaagcgct ggagaaagat gtagcactta agcctcagga acgtgtggag   1080

aaacgccaga cgcccctgac caagaagaaa cgagaagcac ttaccaatgg cttgtccttt   1140

cattcaaaga agagcagact cagccaccca caccactaca gctcagatcg agaaaatgac   1200

cgcaatctct gccagcacct tgggaagaga aagaaaatgc cgaaggcact cagacagctc   1260

aagccaggac agaacagctg cagggacagt gacagtgaaa gtgccagtgg agaatccaag   1320

ggcttccacc ggagcagctc tcgggaaagg ctcagtgata gttcagctcc ttccagcttg   1380

ggaacaggct acttctgtga cagtgacagt gaccaggaag agaaggcatc agatgccagc   1440

tctgaaaaac tcttcaacac tgttattgta aacaaagatc cggagttagg tgttggcacg   1500

ctaccagaac atgacagcca ggatgcaggg ccgattgtcc ccaagatatc gggtctagag   1560

agaagccagg agaagagcca ggactgttgc aaagagccaa tctttgagcc tgtggtgctt   1620

aaagacccct gccctcaggt cgcacagcca ataccccagc cgcagacgga gccccaactc   1680

cgagctcctt ctccggaccc tgacttggtg cagcgcacag aggccccacc tcaaccccca   1740

cctctgagta cacagccacc acagggccct cctgaggccc agctccagcc tgccccgcag   1800

cctcaggtgc agaggccacc caggccacag tcccccaccc agctgctcca tcagaacctc   1860

ccacctgtgc aggcccaccc ctctgctcag agcctctccc agccattgtc agcctacaac   1920

agcagtagct taagcctcaa cagtttaagc agcagcagaa gcagcactcc agcgaagact   1980

cagcccgccc cacctcacat ctcccaccac ccctctgcct ccccgttccc cctctccctg   2040

cccaaccaca gccccctgca cagcttcaca cccaccctcc agccccccgc acactcacat   2100

caccccaata tgtttgcccc tcccactgct ctgcctcctc caccaccact gacatcagga   2160

agtctgcagg tggccggaca cccggccggg agcacttact cagagcaaga catcttgcga   2220

caggaactga acactcgttt tttggcctct cagagtgctg accgcggggc ttccctgggc   2280

cctccgccct acctgcggac cgagttccat cagcaccagc accagcacca gcacacccac   2340

cagcacacgc accagcacac cttcacgccg ttcccccacg ccatcccacc caccgccatc   2400

atgccgacgc cagcacctcc catgtttgac aaatacccta caaaagttga cccattctac   2460

cggcacagtc tcttccattc ctatcctcct gcagtgtcgg gcatcccccc tatgatccca   2520

cccactggcc cttttggttc actacaagga gcatttcagc cgaagacatc caaccctatc   2580

gatgtcgctg ctcggcctgg gacagtccca cacactttac tccaaaagga cccgaggttg   2640

acagatcctt tcagacctat gttaaggaaa ccagggaagt ggtgtgctat gcatgttcac   2700

atcgcctggc agatttacca ccaccaacag aaagtcaaga aacagatgca gtcagaccca   2760

cataagctgg actttggact gaaacctgag ttcctgagcc gccctccagg ccccagtctt   2820

tttggagcca tccaccaccc ccatgacctg gcacggcctt caactttgtt ctctgccgct   2880

ggtgctgcac acccaactgg gacccctttt gggccacctc ctcatcacag caacttcctc   2940

aaccctgctg cccacctaga gccttttaat cggccgtcta cattcacagg cctagcagca   3000

gttggtggca atgccttcgg gggacttgga aatccttccg ttacacccaa ctcaatgttc   3060

ggccacaagg atggccccag tgtgcagaac tttagcaacc ctcacgaacc ctggaaccgg   3120

ctgcaccgaa cgcctccgtc gttcccgacc cctccgccct ggctgaagcc aggggagctg   3180

gagcgcagcg cgtccgctgc agctcatgac agagatagag atgtagataa acgagactca   3240

tctgttagta aagatgacaa agaaagggaa agcgtcgaga agagacactc cagccaccct   3300

tcaccagcac ctgtcctccc ggtgaatgcc ctgggacata cccgcagctc cactgaacag   3360

atccgggctc atctgaacac tgaggctcgg gagaaggaca aacccaaaga gagggagaga   3420

gaccactcgg aatcccgcaa ggacctggcc gccgacgagc acaaggcgaa agagggccac   3480

ctgcccgaga aggacgggca cggccacgag gggcgcgccg cgggcgaaga ggccaagcag   3540

ctggcccggg tgccgtctcc ctacgtgcgg accccggtgg tggagagtgc caggcccaac   3600

agcacctcga gccgggaggc cgagccgcgc aagggtgagc cggcctacga gaaccccaag   3660

aagagctccg aggtcaaggt gaaggaggag cggaaggaag accatgacct gcctccagag   3720

gccccgcaga cccaccgggc ctcggagccg ccgcctccca actcctcgtc cagcgtgcac   3780

ccggggcccc tggcctcgat gcccatgacg gtgggggtga cgggcattca ccccatgaac   3840

agcatcagca gcctggacag gactcgcatg atgaccccct tcatgggcat cagccccctc   3900

ccgggcggag agcgcttccc gtacccttct ttccactggg accccatccg ggaccccttg   3960

agggatcctt accgagaact tgacattcac cggagagacc cgctgggcag ggacttcctg   4020

ctaaggaacg acccgctcca ccggctctcg actccccggc tgtacgaagc cgaccgctcc   4080

ttcagggacc gggagcctca cgactacagc caccaccacc accaccacca ccacccgctg   4140

tctgtggacc ctcggcggga gcacgagcgg ggaggccacc tggacgagcg ggagcgcttg   4200

cacatgctca gagaagacta cgagcacacg cggctccact ccgtgcaccc cgcctccctc   4260

gacggacacc tcccccaccc cagcctcatc accccgggac tccccagcat gcactatccc   4320

cgcatcagcc ccaccgcggg caaccagaac ggactcctca acaagacccc tccgacagca   4380

gcgctgagcg cacctccccc gctcatctcc acgctggggg gccgcccggt ctctcccaga   4440

aggacgactc ctctgtccgc agagataagg gagaggcccc cttcccacac gctgaaggat   4500

atcgaggccc gataagccga gaacaggagc aagaacgagg aagaagaaac cctaggcaga   4560

caccaggcca ggcttgagag acagaactcc tgcatggctc acacagactg ggggggaaag   4620

ccccacccct tccccttgta aaaaatgtat agactcagtg cacattttga aatgttttgt   4680

atattatatg ttgagatttt tcagatcttt tagcccagtc atatgttctc acgtctccta   4740

ctttttgttt ctcgtataaa actttttgat ttgaaccaaa acagtgaaga tgacaacaca   4800

caccaattgg atgataattg tagcgggggc ggtggggggg agaagtccac gccatccatc   4860

atgcaaaatt ctttcagatg aggtgggaag gccgtgtaca tagttatgta aaaagagatt   4920

gcttcatgag ctaatggttc atatatgcaa aagggtaaga tgaaagcttt actttgtaca   4980

aatgtaaata gataaagtaa cataatacat taatacttct taaaatgtgc tatttgcaaa   5040

cttacttaat atcagtgaac acagtcggct aaagctgtgt tcccatatat tgttatagac   5100

agctaaaccc ttcaactatg caatgaatgt tcgggctttt cacaaaagcc cgcctaactc   5160

aaaggagcct tttcaaatcc atttacagca tacttaaggt catattttcc ctgaacaagc   5220

gcttacgtga tatgactctg ttttccttgc ttgttttttt tcaaacggag aaacatcctg   5280

ttttgcaaat tggaccccag gctggaactt agcatctgaa gttgccgctt gtgggctctg   5340

ggggaaagtg tagccccgga gaggtaactg aggacatgag caaccagtgc cagggagggt   5400

gggatttgcc agatgccaaa atcaggggac gggtggtggt gtctgtcaga cacacacagg   5460

tcgccagtga cttcacacac acctcatgtg agaaccatgc cttttttagt gtgtcctatt   5520

tcatacctgt acacacttcc tcgttttgta atgagattta cttacaccca aacagatcct   5580

gaaagaaagc ttcaagtttt ctcagatgat ggatatgttt tcactgtatt caataactga   5640

cggatgtaag gtgcacgttt cctgatgtga cgcactgtat tccagctggt gatcaagtct   5700

gggaacagcc gtaacaggtc aaccttgtgg agccatcgcg agttagaggg tgaaagatgg   5760

cagaaaaaaa agtcttgtgt gtgagtgtgt tttttgagtt tgcatcaatc ttaatgtctc   5820

ttcataatac ttttataata cattaagcct cttgtctaca tatttggaga gaatatgact   5880

ttactagcag agaaatacaa tatatcttgt ctactggact gtaaaatata tgtatgaaat   5940

aaaattagtt ccatttggtc ttctagtata ttaaagtgct atctgacgtt gttatcctgt   6000

ttttgcaaaa aaaaaaaaaa aaaaaagtta actacagacc attgtttcta ataagcagag   6060

agatctattt tagtagtaaa ctgaaggttt agttgtgagc ttcagatttt gtgaactcca   6120

gatgttgtgc ggtgtttttt ttttttttta agacaacaac taaaaaaaat gcaaggaata   6180

tgtacactgg aactgtagtg gtagctttca gtattgtaaa gagattgttc tatacggacc   6240

tttttgctgt ttatcctgta tgtaataaag tcctttctag atcctatgtg aaaagaaaag   6300

tgaagcaact gaatcttcag catgttctca tcggcggagc cttcttgtgt aatgtaaact   6360

gtgccatgtt attaaaaaat gtgaactaag                                    6390


<210>  2399
<211>  1259
<212>  PRT
<213>  Homo sapiens

<400>  2399


Met Asp Gly Pro Thr Arg Gly His Gly Leu Arg Lys Lys Arg Arg Ser 
1               5                   10                  15      


Arg Ser Gln Arg Asp Arg Glu Arg Arg Ser Arg Gly Gly Leu Gly Ala 
            20                  25                  30          


Gly Ala Ala Gly Gly Gly Gly Ala Gly Arg Thr Arg Ala Leu Ser Leu 
        35                  40                  45              


Ala Ser Ser Ser Gly Ser Asp Lys Glu Asp Asn Gly Lys Pro Pro Ser 
    50                  55                  60                  


Ser Ala Pro Ser Arg Pro Arg Pro Pro Arg Arg Lys Arg Arg Glu Ser 
65                  70                  75                  80  


Thr Ser Ala Glu Glu Asp Ile Ile Asp Gly Phe Ala Met Thr Ser Phe 
                85                  90                  95      


Val Thr Phe Glu Ala Leu Glu Lys Asp Val Ala Leu Lys Pro Gln Glu 
            100                 105                 110         


Arg Val Glu Lys Arg Gln Thr Pro Leu Thr Lys Lys Lys Arg Glu Ala 
        115                 120                 125             


Leu Thr Asn Gly Leu Ser Phe His Ser Lys Lys Ser Arg Leu Ser His 
    130                 135                 140                 


Pro His His Tyr Ser Ser Asp Arg Glu Asn Asp Arg Asn Leu Cys Gln 
145                 150                 155                 160 


His Leu Gly Lys Arg Lys Lys Met Pro Lys Ala Leu Arg Gln Leu Lys 
                165                 170                 175     


Pro Gly Gln Asn Ser Cys Arg Asp Ser Asp Ser Glu Ser Ala Ser Gly 
            180                 185                 190         


Glu Ser Lys Gly Phe His Arg Ser Ser Ser Arg Glu Arg Leu Ser Asp 
        195                 200                 205             


Ser Ser Ala Pro Ser Ser Leu Gly Thr Gly Tyr Phe Cys Asp Ser Asp 
    210                 215                 220                 


Ser Asp Gln Glu Glu Lys Ala Ser Asp Ala Ser Ser Glu Lys Leu Phe 
225                 230                 235                 240 


Asn Thr Val Ile Val Asn Lys Asp Pro Glu Leu Gly Val Gly Thr Leu 
                245                 250                 255     


Pro Glu His Asp Ser Gln Asp Ala Gly Pro Ile Val Pro Lys Ile Ser 
            260                 265                 270         


Gly Leu Glu Arg Ser Gln Glu Lys Ser Gln Asp Cys Cys Lys Glu Pro 
        275                 280                 285             


Ile Phe Glu Pro Val Val Leu Lys Asp Pro Cys Pro Gln Val Ala Gln 
    290                 295                 300                 


Pro Ile Pro Gln Pro Gln Thr Glu Pro Gln Leu Arg Ala Pro Ser Pro 
305                 310                 315                 320 


Asp Pro Asp Leu Val Gln Arg Thr Glu Ala Pro Pro Gln Pro Pro Pro 
                325                 330                 335     


Leu Ser Thr Gln Pro Pro Gln Gly Pro Pro Glu Ala Gln Leu Gln Pro 
            340                 345                 350         


Ala Pro Gln Pro Gln Val Gln Arg Pro Pro Arg Pro Gln Ser Pro Thr 
        355                 360                 365             


Gln Leu Leu His Gln Asn Leu Pro Pro Val Gln Ala His Pro Ser Ala 
    370                 375                 380                 


Gln Ser Leu Ser Gln Pro Leu Ser Ala Tyr Asn Ser Ser Ser Leu Ser 
385                 390                 395                 400 


Leu Asn Ser Leu Ser Ser Ser Arg Ser Ser Thr Pro Ala Lys Thr Gln 
                405                 410                 415     


Pro Ala Pro Pro His Ile Ser His His Pro Ser Ala Ser Pro Phe Pro 
            420                 425                 430         


Leu Ser Leu Pro Asn His Ser Pro Leu His Ser Phe Thr Pro Thr Leu 
        435                 440                 445             


Gln Pro Pro Ala His Ser His His Pro Asn Met Phe Ala Pro Pro Thr 
    450                 455                 460                 


Ala Leu Pro Pro Pro Pro Pro Leu Thr Ser Gly Ser Leu Gln Val Ala 
465                 470                 475                 480 


Gly His Pro Ala Gly Ser Thr Tyr Ser Glu Gln Asp Ile Leu Arg Gln 
                485                 490                 495     


Glu Leu Asn Thr Arg Phe Leu Ala Ser Gln Ser Ala Asp Arg Gly Ala 
            500                 505                 510         


Ser Leu Gly Pro Pro Pro Tyr Leu Arg Thr Glu Phe His Gln His Gln 
        515                 520                 525             


His Gln His Gln His Thr His Gln His Thr His Gln His Thr Phe Thr 
    530                 535                 540                 


Pro Phe Pro His Ala Ile Pro Pro Thr Ala Ile Met Pro Thr Pro Ala 
545                 550                 555                 560 


Pro Pro Met Phe Asp Lys Tyr Pro Thr Lys Val Asp Pro Phe Tyr Arg 
                565                 570                 575     


His Ser Leu Phe His Ser Tyr Pro Pro Ala Val Ser Gly Ile Pro Pro 
            580                 585                 590         


Met Ile Pro Pro Thr Gly Pro Phe Gly Ser Leu Gln Gly Ala Phe Gln 
        595                 600                 605             


Pro Lys Thr Ser Asn Pro Ile Asp Val Ala Ala Arg Pro Gly Thr Val 
    610                 615                 620                 


Pro His Thr Leu Leu Gln Lys Asp Pro Arg Leu Thr Asp Pro Phe Arg 
625                 630                 635                 640 


Pro Met Leu Arg Lys Pro Gly Lys Trp Cys Ala Met His Val His Ile 
                645                 650                 655     


Ala Trp Gln Ile Tyr His His Gln Gln Lys Val Lys Lys Gln Met Gln 
            660                 665                 670         


Ser Asp Pro His Lys Leu Asp Phe Gly Leu Lys Pro Glu Phe Leu Ser 
        675                 680                 685             


Arg Pro Pro Gly Pro Ser Leu Phe Gly Ala Ile His His Pro His Asp 
    690                 695                 700                 


Leu Ala Arg Pro Ser Thr Leu Phe Ser Ala Ala Gly Ala Ala His Pro 
705                 710                 715                 720 


Thr Gly Thr Pro Phe Gly Pro Pro Pro His His Ser Asn Phe Leu Asn 
                725                 730                 735     


Pro Ala Ala His Leu Glu Pro Phe Asn Arg Pro Ser Thr Phe Thr Gly 
            740                 745                 750         


Leu Ala Ala Val Gly Gly Asn Ala Phe Gly Gly Leu Gly Asn Pro Ser 
        755                 760                 765             


Val Thr Pro Asn Ser Met Phe Gly His Lys Asp Gly Pro Ser Val Gln 
    770                 775                 780                 


Asn Phe Ser Asn Pro His Glu Pro Trp Asn Arg Leu His Arg Thr Pro 
785                 790                 795                 800 


Pro Ser Phe Pro Thr Pro Pro Pro Trp Leu Lys Pro Gly Glu Leu Glu 
                805                 810                 815     


Arg Ser Ala Ser Ala Ala Ala His Asp Arg Asp Arg Asp Val Asp Lys 
            820                 825                 830         


Arg Asp Ser Ser Val Ser Lys Asp Asp Lys Glu Arg Glu Ser Val Glu 
        835                 840                 845             


Lys Arg His Ser Ser His Pro Ser Pro Ala Pro Val Leu Pro Val Asn 
    850                 855                 860                 


Ala Leu Gly His Thr Arg Ser Ser Thr Glu Gln Ile Arg Ala His Leu 
865                 870                 875                 880 


Asn Thr Glu Ala Arg Glu Lys Asp Lys Pro Lys Glu Arg Glu Arg Asp 
                885                 890                 895     


His Ser Glu Ser Arg Lys Asp Leu Ala Ala Asp Glu His Lys Ala Lys 
            900                 905                 910         


Glu Gly His Leu Pro Glu Lys Asp Gly His Gly His Glu Gly Arg Ala 
        915                 920                 925             


Ala Gly Glu Glu Ala Lys Gln Leu Ala Arg Val Pro Ser Pro Tyr Val 
    930                 935                 940                 


Arg Thr Pro Val Val Glu Ser Ala Arg Pro Asn Ser Thr Ser Ser Arg 
945                 950                 955                 960 


Glu Ala Glu Pro Arg Lys Gly Glu Pro Ala Tyr Glu Asn Pro Lys Lys 
                965                 970                 975     


Ser Ser Glu Val Lys Val Lys Glu Glu Arg Lys Glu Asp His Asp Leu 
            980                 985                 990         


Pro Pro Glu Ala Pro Gln Thr His  Arg Ala Ser Glu Pro  Pro Pro Pro 
        995                 1000                 1005             


Asn Ser  Ser Ser Ser Val His  Pro Gly Pro Leu Ala  Ser Met Pro 
    1010                 1015                 1020             


Met Thr  Val Gly Val Thr Gly  Ile His Pro Met Asn  Ser Ile Ser 
    1025                 1030                 1035             


Ser Leu  Asp Arg Thr Arg Met  Met Thr Pro Phe Met  Gly Ile Ser 
    1040                 1045                 1050             


Pro Leu  Pro Gly Gly Glu Arg  Phe Pro Tyr Pro Ser  Phe His Trp 
    1055                 1060                 1065             


Asp Pro  Ile Arg Asp Pro Leu  Arg Asp Pro Tyr Arg  Glu Leu Asp 
    1070                 1075                 1080             


Ile His  Arg Arg Asp Pro Leu  Gly Arg Asp Phe Leu  Leu Arg Asn 
    1085                 1090                 1095             


Asp Pro  Leu His Arg Leu Ser  Thr Pro Arg Leu Tyr  Glu Ala Asp 
    1100                 1105                 1110             


Arg Ser  Phe Arg Asp Arg Glu  Pro His Asp Tyr Ser  His His His 
    1115                 1120                 1125             


His His  His His His Pro Leu  Ser Val Asp Pro Arg  Arg Glu His 
    1130                 1135                 1140             


Glu Arg  Gly Gly His Leu Asp  Glu Arg Glu Arg Leu  His Met Leu 
    1145                 1150                 1155             


Arg Glu  Asp Tyr Glu His Thr  Arg Leu His Ser Val  His Pro Ala 
    1160                 1165                 1170             


Ser Leu  Asp Gly His Leu Pro  His Pro Ser Leu Ile  Thr Pro Gly 
    1175                 1180                 1185             


Leu Pro  Ser Met His Tyr Pro  Arg Ile Ser Pro Thr  Ala Gly Asn 
    1190                 1195                 1200             


Gln Asn  Gly Leu Leu Asn Lys  Thr Pro Pro Thr Ala  Ala Leu Ser 
    1205                 1210                 1215             


Ala Pro  Pro Pro Leu Ile Ser  Thr Leu Gly Gly Arg  Pro Val Ser 
    1220                 1225                 1230             


Pro Arg  Arg Thr Thr Pro Leu  Ser Ala Glu Ile Arg  Glu Arg Pro 
    1235                 1240                 1245             


Pro Ser  His Thr Leu Lys Asp  Ile Glu Ala Arg 
    1250                 1255                 

<210>  2400
<211>  6318
<212>  DNA
<213>  Homo sapiens

<400>  2400
cgctcgcagt ttcgccctct cttccgctaa tgattgcatt attatgctcc cctctctggg     60

gggtctcgcc cctcttgggt cgctccggag ccccggcctc ccctggctgc atttcttaaa    120

aatttgggag cctgggagtg agttttctcc gaggcgtgtg tgagaggcgg cgggggtgtt    180

ttcctgcgcg aggggcgggt gaagttcatt gcccccactt ttcccgcgac ctttttcgga    240

cccgattttg gatcgagttg aggggggcgc gggcgttttc ggggggcggg gggcgcggcg    300

gagaatggcc gcggggaggg ctccccggag cctcccagtc tcttgatcaa agcattccgc    360

tattctgatt tattgcttgc ttggtgagtt attttttttt cctctaaagg agacctgtgt    420

gttcagccat tactttgctc ggcgctgctc ccaggcatct ccgaccctcg gtgctgtggg    480

gagccccaca cttgggctcc tcgcctctcg ccctcgctcc ccgtccctcc tcccctctct    540

ccgccccttc ccccttttct ttctcctctc tttcttcccc tctctccctt ctttcggccg    600

ccgtctcccc cgcgccctcc tcggggcgga gggaagccgt gaagggggag ggagggctcg    660

gtgtcaattt ttttttgtgt ggctgcggcc gtagcctgtg gcgggcaagc ggggagaccc    720

cggcgcagca gaaccatgga tggcccgacg cggggccatg gactccgcaa aaagcggcgg    780

tcgcggtcgc agcgagaccg ggagaggcgc tcccggggcg ggctgggggc cggcgcggcc    840

ggcggcggcg gggctggccg gacccgggcg ctctcactcg cctcgtcgtc gggctccgac    900

aaggaagaca atgggaagcc cccgtcctcc gccccgtccc ggcccagacc cccgcggagg    960

aagcggagag agtccacctc ggcagaagag gacatcattg atggatttgc catgaccagc   1020

tttgtcactt ttgaagcgct ggagaaagat gtagcactta agcctcagga acgtgtggag   1080

aaacgccaga cgcccctgac caagaagaaa cgagaagcac ttaccaatgg cttgtccttt   1140

cattcaaaga agagcagact cagccaccca caccactaca gctcagatcg agaaaatgac   1200

cgcaatctct gccagcacct tgggaagaga aagaaaatgc cgaaggcact cagacagctc   1260

aagccaggac agaacagctg cagggacagt gacagtgaaa gtgccagtgg agaatccaag   1320

ggcttccacc ggagcagctc tcgggaaagg ctcagtgata gttcagctcc ttccagcttg   1380

ggaacaggct acttctgtga cagtgacagt gaccaggaag agaaggcatc agatgccagc   1440

tctgaaaaac tcttcaacac tgttattgta aacaaagatc cggagttagg tgttggcacg   1500

ctaccagaac atgacagcca ggatgcaggg ccgattgtcc ccaagatatc gggtctagag   1560

agaagccagg agaagagcca ggactgttgc aaagagccaa tctttgagcc tgtggtgctt   1620

aaagacccct gccctcaggt cgcacagcca ataccccagc cgcagacgga gccccaactc   1680

cgagctcctt ctccggaccc tgacttggtg cagcgcacag aggccccacc tcaaccccca   1740

cctctgagta cacagccacc acagggccct cctgaggccc agctccagcc tgccccgcag   1800

cctcaggtgc agaggccacc caggccacag tcccccaccc agctgctcca tcagaacctc   1860

ccacctgtgc aggcccaccc ctctgctcag agcctctccc agccattgtc agcctacaac   1920

agcagtagct taagcctcaa cagtttaagc agcagcagaa gcagcactcc agcgaagact   1980

cagcccgccc cacctcacat ctcccaccac ccctctgcct ccccgttccc cctctccctg   2040

cccaaccaca gccccctgca cagcttcaca cccaccctcc agccccccgc acactcacat   2100

caccccaata tgtttgcccc tcccactgct ctgcctcctc caccaccact gacatcagga   2160

agtctgcagg tggccggaca cccggccggg agcacttact cagagcaaga catcttgcga   2220

caggaactga acactcgttt tttggcctct cagagtgctg accgcggggc ttccctgggc   2280

cctccgccct acctgcggac cgagttccat cagcaccagc accagcacca gcacacccac   2340

cagcacacgc accagcacac cttcacgccg ttcccccacg ccatcccacc caccgccatc   2400

atgccgacgc cagcacctcc catgtttgac aaatacccta caaaagttga cccattctac   2460

cggcacagtc tcttccattc ctatcctcct gcagtgtcgg gcatcccccc tatgatccca   2520

cccactggcc cttttggttc actacaagga gcatttcagc cgaagttgac agatcctttc   2580

agacctatgt taaggaaacc agggaagtgg tgtgctatgc atgttcacat cgcctggcag   2640

atttaccacc accaacagaa agtcaagaaa cagatgcagt cagacccaca taagctggac   2700

tttggactga aacctgagtt cctgagccgc cctccaggcc ccagtctttt tggagccatc   2760

caccaccccc atgacctggc acggccttca actttgttct ctgccgctgg tgctgcacac   2820

ccaactggga ccccttttgg gccacctcct catcacagca acttcctcaa ccctgctgcc   2880

cacctagagc cttttaatcg gccgtctaca ttcacaggcc tagcagcagt tggtggcaat   2940

gccttcgggg gacttggaaa tccttccgtt acacccaact caatgttcgg ccacaaggat   3000

ggccccagtg tgcagaactt tagcaaccct cacgaaccct ggaaccggct gcaccgaacg   3060

cctccgtcgt tcccgacccc tccgccctgg ctgaagccag gggagctgga gcgcagcgcg   3120

tccgctgcag ctcatgacag agatagagat gtagataaac gagactcatc tgttagtaaa   3180

gatgacaaag aaagggaaag cgtcgagaag agacactcca gccacccttc accagcacct   3240

gtcctcccgg tgaatgccct gggacatacc cgcagctcca ctgaacagat ccgggctcat   3300

ctgaacactg aggctcggga gaaggacaaa cccaaagaga gggagagaga ccactcggaa   3360

tcccgcaagg acctggccgc cgacgagcac aaggcgaaag agggccacct gcccgagaag   3420

gacgggcacg gccacgaggg gcgcgccgcg ggcgaagagg ccaagcagct ggcccgggtg   3480

ccgtctccct acgtgcggac cccggtggtg gagagtgcca ggcccaacag cacctcgagc   3540

cgggaggccg agccgcgcaa gggtgagccg gcctacgaga accccaagaa gagctccgag   3600

gtcaaggtga aggaggagcg gaaggaagac catgacctgc ctccagaggc cccgcagacc   3660

caccgggcct cggagccgcc gcctcccaac tcctcgtcca gcgtgcaccc ggggcccctg   3720

gcctcgatgc ccatgacggt gggggtgacg ggcattcacc ccatgaacag catcagcagc   3780

ctggacagga ctcgcatgat gacccccttc atgggcatca gccccctccc gggcggagag   3840

cgcttcccgt acccttcttt ccactgggac cccatccggg accccttgag ggatccttac   3900

cgagaacttg acattcaccg gagagacccg ctgggcaggg acttcctgct aaggaacgac   3960

ccgctccacc ggctctcgac tccccggctg tacgaagccg accgctcctt cagggaccgg   4020

gagcctcacg actacagcca ccaccaccac caccaccacc acccgctgtc tgtggaccct   4080

cggcgggagc acgagcgggg aggccacctg gacgagcggg agcgcttgca catgctcaga   4140

gaagactacg agcacacgcg gctccactcc gtgcaccccg cctccctcga cggacacctc   4200

ccccacccca gcctcatcac cccgggactc cccagcatgc actatccccg catcagcccc   4260

accgcgggca accagaacgg actcctcaac aagacccctc cgacagcagc gctgagcgca   4320

cctcccccgc tcatctccac gctggggggc cgcccggtct ctcccagaag gacgactcct   4380

ctgtccgcag agataaggga gaggccccct tcccacacgc tgaaggatat cgaggcccga   4440

taagccgaga acaggagcaa gaacgaggaa gaagaaaccc taggcagaca ccaggccagg   4500

cttgagagac agaactcctg catggctcac acagactggg ggggaaagcc ccaccccttc   4560

cccttgtaaa aaatgtatag actcagtgca cattttgaaa tgttttgtat attatatgtt   4620

gagatttttc agatctttta gcccagtcat atgttctcac gtctcctact ttttgtttct   4680

cgtataaaac tttttgattt gaaccaaaac agtgaagatg acaacacaca ccaattggat   4740

gataattgta gcgggggcgg tgggggggag aagtccacgc catccatcat gcaaaattct   4800

ttcagatgag gtgggaaggc cgtgtacata gttatgtaaa aagagattgc ttcatgagct   4860

aatggttcat atatgcaaaa gggtaagatg aaagctttac tttgtacaaa tgtaaataga   4920

taaagtaaca taatacatta atacttctta aaatgtgcta tttgcaaact tacttaatat   4980

cagtgaacac agtcggctaa agctgtgttc ccatatattg ttatagacag ctaaaccctt   5040

caactatgca atgaatgttc gggcttttca caaaagcccg cctaactcaa aggagccttt   5100

tcaaatccat ttacagcata cttaaggtca tattttccct gaacaagcgc ttacgtgata   5160

tgactctgtt ttccttgctt gttttttttc aaacggagaa acatcctgtt ttgcaaattg   5220

gaccccaggc tggaacttag catctgaagt tgccgcttgt gggctctggg ggaaagtgta   5280

gccccggaga ggtaactgag gacatgagca accagtgcca gggagggtgg gatttgccag   5340

atgccaaaat caggggacgg gtggtggtgt ctgtcagaca cacacaggtc gccagtgact   5400

tcacacacac ctcatgtgag aaccatgcct tttttagtgt gtcctatttc atacctgtac   5460

acacttcctc gttttgtaat gagatttact tacacccaaa cagatcctga aagaaagctt   5520

caagttttct cagatgatgg atatgttttc actgtattca ataactgacg gatgtaaggt   5580

gcacgtttcc tgatgtgacg cactgtattc cagctggtga tcaagtctgg gaacagccgt   5640

aacaggtcaa ccttgtggag ccatcgcgag ttagagggtg aaagatggca gaaaaaaaag   5700

tcttgtgtgt gagtgtgttt tttgagtttg catcaatctt aatgtctctt cataatactt   5760

ttataataca ttaagcctct tgtctacata tttggagaga atatgacttt actagcagag   5820

aaatacaata tatcttgtct actggactgt aaaatatatg tatgaaataa aattagttcc   5880

atttggtctt ctagtatatt aaagtgctat ctgacgttgt tatcctgttt ttgcaaaaaa   5940

aaaaaaaaaa aaaagttaac tacagaccat tgtttctaat aagcagagag atctatttta   6000

gtagtaaact gaaggtttag ttgtgagctt cagattttgt gaactccaga tgttgtgcgg   6060

tgtttttttt tttttttaag acaacaacta aaaaaaatgc aaggaatatg tacactggaa   6120

ctgtagtggt agctttcagt attgtaaaga gattgttcta tacggacctt tttgctgttt   6180

atcctgtatg taataaagtc ctttctagat cctatgtgaa aagaaaagtg aagcaactga   6240

atcttcagca tgttctcatc ggcggagcct tcttgtgtaa tgtaaactgt gccatgttat   6300

taaaaaatgt gaactaag                                                 6318


<210>  2401
<211>  1235
<212>  PRT
<213>  Homo sapiens

<400>  2401


Met Asp Gly Pro Thr Arg Gly His Gly Leu Arg Lys Lys Arg Arg Ser 
1               5                   10                  15      


Arg Ser Gln Arg Asp Arg Glu Arg Arg Ser Arg Gly Gly Leu Gly Ala 
            20                  25                  30          


Gly Ala Ala Gly Gly Gly Gly Ala Gly Arg Thr Arg Ala Leu Ser Leu 
        35                  40                  45              


Ala Ser Ser Ser Gly Ser Asp Lys Glu Asp Asn Gly Lys Pro Pro Ser 
    50                  55                  60                  


Ser Ala Pro Ser Arg Pro Arg Pro Pro Arg Arg Lys Arg Arg Glu Ser 
65                  70                  75                  80  


Thr Ser Ala Glu Glu Asp Ile Ile Asp Gly Phe Ala Met Thr Ser Phe 
                85                  90                  95      


Val Thr Phe Glu Ala Leu Glu Lys Asp Val Ala Leu Lys Pro Gln Glu 
            100                 105                 110         


Arg Val Glu Lys Arg Gln Thr Pro Leu Thr Lys Lys Lys Arg Glu Ala 
        115                 120                 125             


Leu Thr Asn Gly Leu Ser Phe His Ser Lys Lys Ser Arg Leu Ser His 
    130                 135                 140                 


Pro His His Tyr Ser Ser Asp Arg Glu Asn Asp Arg Asn Leu Cys Gln 
145                 150                 155                 160 


His Leu Gly Lys Arg Lys Lys Met Pro Lys Ala Leu Arg Gln Leu Lys 
                165                 170                 175     


Pro Gly Gln Asn Ser Cys Arg Asp Ser Asp Ser Glu Ser Ala Ser Gly 
            180                 185                 190         


Glu Ser Lys Gly Phe His Arg Ser Ser Ser Arg Glu Arg Leu Ser Asp 
        195                 200                 205             


Ser Ser Ala Pro Ser Ser Leu Gly Thr Gly Tyr Phe Cys Asp Ser Asp 
    210                 215                 220                 


Ser Asp Gln Glu Glu Lys Ala Ser Asp Ala Ser Ser Glu Lys Leu Phe 
225                 230                 235                 240 


Asn Thr Val Ile Val Asn Lys Asp Pro Glu Leu Gly Val Gly Thr Leu 
                245                 250                 255     


Pro Glu His Asp Ser Gln Asp Ala Gly Pro Ile Val Pro Lys Ile Ser 
            260                 265                 270         


Gly Leu Glu Arg Ser Gln Glu Lys Ser Gln Asp Cys Cys Lys Glu Pro 
        275                 280                 285             


Ile Phe Glu Pro Val Val Leu Lys Asp Pro Cys Pro Gln Val Ala Gln 
    290                 295                 300                 


Pro Ile Pro Gln Pro Gln Thr Glu Pro Gln Leu Arg Ala Pro Ser Pro 
305                 310                 315                 320 


Asp Pro Asp Leu Val Gln Arg Thr Glu Ala Pro Pro Gln Pro Pro Pro 
                325                 330                 335     


Leu Ser Thr Gln Pro Pro Gln Gly Pro Pro Glu Ala Gln Leu Gln Pro 
            340                 345                 350         


Ala Pro Gln Pro Gln Val Gln Arg Pro Pro Arg Pro Gln Ser Pro Thr 
        355                 360                 365             


Gln Leu Leu His Gln Asn Leu Pro Pro Val Gln Ala His Pro Ser Ala 
    370                 375                 380                 


Gln Ser Leu Ser Gln Pro Leu Ser Ala Tyr Asn Ser Ser Ser Leu Ser 
385                 390                 395                 400 


Leu Asn Ser Leu Ser Ser Ser Arg Ser Ser Thr Pro Ala Lys Thr Gln 
                405                 410                 415     


Pro Ala Pro Pro His Ile Ser His His Pro Ser Ala Ser Pro Phe Pro 
            420                 425                 430         


Leu Ser Leu Pro Asn His Ser Pro Leu His Ser Phe Thr Pro Thr Leu 
        435                 440                 445             


Gln Pro Pro Ala His Ser His His Pro Asn Met Phe Ala Pro Pro Thr 
    450                 455                 460                 


Ala Leu Pro Pro Pro Pro Pro Leu Thr Ser Gly Ser Leu Gln Val Ala 
465                 470                 475                 480 


Gly His Pro Ala Gly Ser Thr Tyr Ser Glu Gln Asp Ile Leu Arg Gln 
                485                 490                 495     


Glu Leu Asn Thr Arg Phe Leu Ala Ser Gln Ser Ala Asp Arg Gly Ala 
            500                 505                 510         


Ser Leu Gly Pro Pro Pro Tyr Leu Arg Thr Glu Phe His Gln His Gln 
        515                 520                 525             


His Gln His Gln His Thr His Gln His Thr His Gln His Thr Phe Thr 
    530                 535                 540                 


Pro Phe Pro His Ala Ile Pro Pro Thr Ala Ile Met Pro Thr Pro Ala 
545                 550                 555                 560 


Pro Pro Met Phe Asp Lys Tyr Pro Thr Lys Val Asp Pro Phe Tyr Arg 
                565                 570                 575     


His Ser Leu Phe His Ser Tyr Pro Pro Ala Val Ser Gly Ile Pro Pro 
            580                 585                 590         


Met Ile Pro Pro Thr Gly Pro Phe Gly Ser Leu Gln Gly Ala Phe Gln 
        595                 600                 605             


Pro Lys Leu Thr Asp Pro Phe Arg Pro Met Leu Arg Lys Pro Gly Lys 
    610                 615                 620                 


Trp Cys Ala Met His Val His Ile Ala Trp Gln Ile Tyr His His Gln 
625                 630                 635                 640 


Gln Lys Val Lys Lys Gln Met Gln Ser Asp Pro His Lys Leu Asp Phe 
                645                 650                 655     


Gly Leu Lys Pro Glu Phe Leu Ser Arg Pro Pro Gly Pro Ser Leu Phe 
            660                 665                 670         


Gly Ala Ile His His Pro His Asp Leu Ala Arg Pro Ser Thr Leu Phe 
        675                 680                 685             


Ser Ala Ala Gly Ala Ala His Pro Thr Gly Thr Pro Phe Gly Pro Pro 
    690                 695                 700                 


Pro His His Ser Asn Phe Leu Asn Pro Ala Ala His Leu Glu Pro Phe 
705                 710                 715                 720 


Asn Arg Pro Ser Thr Phe Thr Gly Leu Ala Ala Val Gly Gly Asn Ala 
                725                 730                 735     


Phe Gly Gly Leu Gly Asn Pro Ser Val Thr Pro Asn Ser Met Phe Gly 
            740                 745                 750         


His Lys Asp Gly Pro Ser Val Gln Asn Phe Ser Asn Pro His Glu Pro 
        755                 760                 765             


Trp Asn Arg Leu His Arg Thr Pro Pro Ser Phe Pro Thr Pro Pro Pro 
    770                 775                 780                 


Trp Leu Lys Pro Gly Glu Leu Glu Arg Ser Ala Ser Ala Ala Ala His 
785                 790                 795                 800 


Asp Arg Asp Arg Asp Val Asp Lys Arg Asp Ser Ser Val Ser Lys Asp 
                805                 810                 815     


Asp Lys Glu Arg Glu Ser Val Glu Lys Arg His Ser Ser His Pro Ser 
            820                 825                 830         


Pro Ala Pro Val Leu Pro Val Asn Ala Leu Gly His Thr Arg Ser Ser 
        835                 840                 845             


Thr Glu Gln Ile Arg Ala His Leu Asn Thr Glu Ala Arg Glu Lys Asp 
    850                 855                 860                 


Lys Pro Lys Glu Arg Glu Arg Asp His Ser Glu Ser Arg Lys Asp Leu 
865                 870                 875                 880 


Ala Ala Asp Glu His Lys Ala Lys Glu Gly His Leu Pro Glu Lys Asp 
                885                 890                 895     


Gly His Gly His Glu Gly Arg Ala Ala Gly Glu Glu Ala Lys Gln Leu 
            900                 905                 910         


Ala Arg Val Pro Ser Pro Tyr Val Arg Thr Pro Val Val Glu Ser Ala 
        915                 920                 925             


Arg Pro Asn Ser Thr Ser Ser Arg Glu Ala Glu Pro Arg Lys Gly Glu 
    930                 935                 940                 


Pro Ala Tyr Glu Asn Pro Lys Lys Ser Ser Glu Val Lys Val Lys Glu 
945                 950                 955                 960 


Glu Arg Lys Glu Asp His Asp Leu Pro Pro Glu Ala Pro Gln Thr His 
                965                 970                 975     


Arg Ala Ser Glu Pro Pro Pro Pro Asn Ser Ser Ser Ser Val His Pro 
            980                 985                 990         


Gly Pro Leu Ala Ser Met Pro Met  Thr Val Gly Val Thr  Gly Ile His 
        995                 1000                 1005             


Pro Met  Asn Ser Ile Ser Ser  Leu Asp Arg Thr Arg  Met Met Thr 
    1010                 1015                 1020             


Pro Phe  Met Gly Ile Ser Pro  Leu Pro Gly Gly Glu  Arg Phe Pro 
    1025                 1030                 1035             


Tyr Pro  Ser Phe His Trp Asp  Pro Ile Arg Asp Pro  Leu Arg Asp 
    1040                 1045                 1050             


Pro Tyr  Arg Glu Leu Asp Ile  His Arg Arg Asp Pro  Leu Gly Arg 
    1055                 1060                 1065             


Asp Phe  Leu Leu Arg Asn Asp  Pro Leu His Arg Leu  Ser Thr Pro 
    1070                 1075                 1080             


Arg Leu  Tyr Glu Ala Asp Arg  Ser Phe Arg Asp Arg  Glu Pro His 
    1085                 1090                 1095             


Asp Tyr  Ser His His His His  His His His His Pro  Leu Ser Val 
    1100                 1105                 1110             


Asp Pro  Arg Arg Glu His Glu  Arg Gly Gly His Leu  Asp Glu Arg 
    1115                 1120                 1125             


Glu Arg  Leu His Met Leu Arg  Glu Asp Tyr Glu His  Thr Arg Leu 
    1130                 1135                 1140             


His Ser  Val His Pro Ala Ser  Leu Asp Gly His Leu  Pro His Pro 
    1145                 1150                 1155             


Ser Leu  Ile Thr Pro Gly Leu  Pro Ser Met His Tyr  Pro Arg Ile 
    1160                 1165                 1170             


Ser Pro  Thr Ala Gly Asn Gln  Asn Gly Leu Leu Asn  Lys Thr Pro 
    1175                 1180                 1185             


Pro Thr  Ala Ala Leu Ser Ala  Pro Pro Pro Leu Ile  Ser Thr Leu 
    1190                 1195                 1200             


Gly Gly  Arg Pro Val Ser Pro  Arg Arg Thr Thr Pro  Leu Ser Ala 
    1205                 1210                 1215             


Glu Ile  Arg Glu Arg Pro Pro  Ser His Thr Leu Lys  Asp Ile Glu 
    1220                 1225                 1230             


Ala Arg  
    1235 

<210>  2402
<211>  6517
<212>  DNA
<213>  Homo sapiens

<400>  2402
cgctcgcagt ttcgccctct cttccgctaa tgattgcatt attatgctcc cctctctggg     60

gggtctcgcc cctcttgggt cgctccggag ccccggcctc ccctggctgc atttcttaaa    120

aatttgggag cctgggagtg agttttctcc gaggcgtgtg tgagaggcgg cgggggtgtt    180

ttcctgcgcg aggggcgggt gaagttcatt gcccccactt ttcccgcgac ctttttcgga    240

cccgattttg gatcgagttg aggggggcgc gggcgttttc ggggggcggg gggcgcggcg    300

gagaatggcc gcggggaggg ctccccggag cctcccagtc tcttgatcaa agcattccgc    360

tattctgatt tattgcttgc ttggtgagtt attttttttt cctctaaagg agacctgtgt    420

gttcagccat tactttgctc ggcgctgctc ccaggcatct ccgaccctcg gtgctgtggg    480

gagccccaca cttgggctcc tcgcctctcg ccctcgctcc ccgtccctcc tcccctctct    540

ccgccccttc ccccttttct ttctcctctc tttcttcccc tctctccctt ctttcggccg    600

ccgtctcccc cgcgccctcc tcggggcgga gggaagccgt gaagggggag ggagggctcg    660

gtgtcaattt ttttttgtgt ggctgcggcc gtagcctgtg gcgggcaagc ggggagaccc    720

cggcgcagca gaaccatgga tggcccgacg cggggccatg gactccgcaa aaagcggcgg    780

tcgcggtcgc agcgagaccg ggagaggcgc tcccggggcg ggctgggggc cggcgcggcc    840

ggcggcggcg gggctggccg gacccgggcg ctctcactcg cctcgtcgtc gggctccgac    900

aaggaagaca atgggaagcc cccgtcctcc gccccgtccc ggcccagacc cccgcggagg    960

aagcggagag agtccacctc ggcagaagag gacatcattg atggatttgc catgaccagc   1020

tttgtcactt ttgaagcgct ggagaaagat gtagcactta agcctcagga acgtgtggag   1080

aaacgccaga cgcccctgac caagaagaaa cgagaagcac ttaccaatgg cttgtccttt   1140

cattcaaaga agagcagact cagccaccca caccactaca gctcagatcg agaaaatgac   1200

cgcaatctct gccagcacct tgggaagaga aagaaaatgc cgaaggcact cagacagctc   1260

aagccaggac agaacagctg cagggacagt gacagtgaaa gtgccagtgg agaatccaag   1320

ggcttccacc ggagcagctc tcgggaaagg ctcagtgata gttcagctcc ttccagcttg   1380

ggaacaggct acttctgtga cagtgacagt gaccaggaag agaaggcatc agatgccagc   1440

tctgaaaaac tcttcaacac tgttattgta aacaaagatc cggagttagg tgttggcacg   1500

ctaccagaac atgacagcca ggatgcaggg ccgattgtcc ccaagatatc gggtctagag   1560

agaagccagg agaagagcca ggactgttgc aaagagccaa tctttgagcc tgtggtgctt   1620

aaagacccct gccctcaggt cgcacagcca ataccccagc cgcagacgga gccccaactc   1680

cgagctcctt ctccggaccc tgacttggtg cagcgcacag aggccccacc tcaaccccca   1740

cctctgagta cacagccacc acagggccct cctgaggccc agctccagcc tgccccgcag   1800

cctcaggtgc agaggccacc caggccacag tcccccaccc agctgctcca tcagaacctc   1860

ccacctgtgc aggcccaccc ctctgctcag agcctctccc agccattgtc agcctacaac   1920

agcagtagct taagcctcaa cagtttaagc agcagcagaa gcagcactcc agcgaagact   1980

cagcccgccc cacctcacat ctcccaccac ccctctgcct ccccgttccc cctctccctg   2040

cccaaccaca gccccctgca cagcttcaca cccaccctcc agccccccgc acactcacat   2100

caccccaata tgtttgcccc tcccactgct ctgcctcctc caccaccact gacatcagga   2160

agtctgcagg tggccggaca cccggccggg agcacttact cagagcaaga catcttgcga   2220

caggaactga acactcgttt tttggcctct cagagtgctg accgcggggc ttccctgggc   2280

cctccgccct acctgcggac cgagttccat cagcaccagc accagcacca gcacacccac   2340

cagcacacgc accagcacac cttcacgccg ttcccccacg ccatcccacc caccgccatc   2400

atgccgacgc cagcacctcc catgtttgac aaatacccta caaaagttga cccattctac   2460

cggcacagtc tcttccattc ctatcctcct gcagtgtcgg gcatcccccc tatgatccca   2520

cccactggcc cttttggttc actacaagga gcatttcagc cgaagttgac agatcctttc   2580

agacctatgt taaggaaacc agggaagtgg tgtgctatgc atgttcacat cgcctggcag   2640

atttaccacc accaacagaa agtcaagaaa cagatgcagt cagacccaca taagctggac   2700

tttggactga aacctgagtt cctgagccgc cctccaggcc ccagtctttt tggagccatc   2760

caccaccccc atgacctggc acggccttca actttgttct ctgccgctgg tgctgcacac   2820

ccaactggga ccccttttgg gccacctcct catcacagca acttcctcaa ccctgctgcc   2880

cacctagagc cttttaatcg gccgtctaca ttcacaggcc tagcagcagt tggtggcaat   2940

gccttcgggg gacttggaaa tccttccgtt acacccaact caatgttcgg ccacaaggat   3000

ggccccagtg tgcagaactt tagcaaccct cacgaaccct ggaaccggct gcaccgaacg   3060

cctccgtcgt tcccgacccc tccgccctgg ctgaagccag gggagctgga gcgcagcgcg   3120

tccgctgcag ctcatgacag agatagagat gtagataaac gagactcatc tgttagtaaa   3180

gatgacaaag aaagggaaag cgtcgagaag agacactcca gccacccttc accagcacct   3240

gtcctcccgg tgaatgccct gggacatacc cgcagctcca ctgaacagat ccgggctcat   3300

ctgaacactg aggctcggga gaaggacaaa cccaaagaga gggagagaga ccactcggaa   3360

tcccgcaagg acctggccgc cgacgagcac aaggcgaaag agggccacct gcccgagaag   3420

gacgggcacg gccacgaggg gcgcgccgcg ggcgaagagg ccaagcagct ggcccgggtg   3480

ccgtctccct acgtgcggac cccggtggtg gagagtgcca ggcccaacag cacctcgagc   3540

cgggaggccg agccgcgcaa gggtgagccg gcctacgaga accccaagaa gagctccgag   3600

gtcaaggtga aggaggagcg gaaggaagac catgacctgc ctccagaggc cccgcagacc   3660

caccgggcct cggagccgcc gcctcccaac tcctcgtcca gcgtgcaccc ggggcccctg   3720

gcctcgatgc ccatgacggt gggggtgacg ggcattcacc ccatgaacag catcagcagc   3780

ctggacagga ctcgcatgat gacccccttc atgggcatca gccccctccc gggcggagag   3840

cgcttcccgt acccttcttt ccactgggac cccatccggg accccttgag ggatccttac   3900

cgagaacttg acattcaccg gagagacccg ctgggcaggg acttcctgct aaggaacgac   3960

ccgctccacc ggctctcgac tccccggctg tacgaagccg accgctcctt cagggaccgg   4020

gagcctcacg actacagcca ccaccaccac caccaccacc acccgctgtc tgtggaccct   4080

cggcgggagc acgagcgggg aggccacctg gacgagcggg agcgcttgca catgctcaga   4140

gaagactacg agcacacgcg gctccactcc gtgcaccccg cctccctcga cggacacctc   4200

ccccacccca gcctcatcac cccgggactc cccagcatgc actatccccg catcagcccc   4260

accgcgggca accagaacgg actcctcaac aagacccctc cgacagcagc gctgagcgca   4320

cctcccccgc tcatctccac gctggggggc cgcccggtct ctcccagaag gacgactcct   4380

ctgtccgcag agataaggga gaggccccct tcccacacgc tgaaggatat cgaggcccga   4440

taagccgaga acaggagcaa gaacgaggaa gaagaaaccc taggcagaca ccaggccagg   4500

cttgagagac agaactcctg catggctcac acagactggg ggggaaagcc ccaccccttc   4560

cccttgtaaa aaatgtatag actcagtgca cattttgaaa tgttttgtat attatatgtt   4620

gagatttttc agatctttta gcccagtcat atgttctcac gtctcctact ttttgtttct   4680

cgtataaaac tttttgattt gaaccaaaac agtgaagatg acaacacaca ccaattggat   4740

gataattgta gcgggggcgg tgggggggag aagtccacgc catccatcat gcaaaattct   4800

ttcagatgag gtgggaaggc cgtgtacata gttatgtaaa aagagattgc ttcatgagct   4860

aatggttcat atatgcaaaa gggtaagatg aaagctttac tttgtacaaa tgtaaataga   4920

taaagtaaca taatacatta atacttctta aaatgtgcta tttgcaaact tacttaatat   4980

cagtgaacac agtcggctaa agctgtgttc ccatatattg ttatagacag ctaaaccctt   5040

caactatgca atgaatgttc gggcttttca caaaagcccg cctaactcaa aggagccttt   5100

tcaaatccat ttacagcata cttaaggtca tattttccct gaacaagcgc ttacgtgata   5160

tgactctgtt ttccttgctt gttttttttc aaacggagaa acatcctgtt ttgcaaattg   5220

gaccccaggc tggaacttag catctgaagt tgccgcttgt gggctctggg ggaaagtgta   5280

gccccggaga ggtaactgag gacatgagca accagtgcca gggagggtgg gatttgccag   5340

atgccaaaat caggggacgg gtggtggtgt ctgtcagaca cacacaggtc gccagtgact   5400

tcacacacac ctcatgtgag aaccatgcct tttttagtgt gtcctatttc atacctgtac   5460

acacttcctc gttttgtaat gagatttact tacacccaaa cagatcctga aagaaagctt   5520

caagttttct cagatgatgg atatgttttc actgtattca ataactgacg gatgtaaggt   5580

gcacgtttcc tgatgtgacg cactgtattc cagctggtga tcaagtctgg gaacagccgt   5640

aacaggtcaa ccttgtggag ccatcgcgag ttagagggtg aaagatggca gaaaaaaaag   5700

tcttgtgtgt gagtgtgttt tttgagtttg catcaatctt aatgtctctt cataatactt   5760

ttataataca ttaagcctct tgtctacata tttggagaga atatgacttt actagcagag   5820

aaatacaata tatcttgtct actggactgt aaaatatatg tatgaaataa aattagttcc   5880

atttggtctt ctagtatatt aaagtgctat ctgacgttgt tatcctgttt ttgcaaaaaa   5940

aaaaaaaaaa aaaagttaac tacagaccat tgtttctaat aagcagagag atctatttta   6000

gtagtaaact gaaggtttag ttgtgagctt cagattttgt gaactccaga tgttgtgcgg   6060

tgtttttttt tttttttaag acaacaacta aaaaaaatgc aaggaatatg tacactggaa   6120

ctgtagtggt agctttcagt attgtaaaga gattgttcta tacggacctt tttgctgttt   6180

atcctgtatg taataaagtc ctttctagat cctatgtgaa aagaaaagtg aagcaactga   6240

atcttcagca tgttctcatc ggcggagcct tcttgtgtaa tgtaaactgt gccatgttat   6300

taaaaaatgt gaactaagct tccagctgct tgtttgtgtg aggtgaccat cattacctta   6360

gggaagaagc catacctgta caagaccggg ctcttgaaaa gaaacacctc gaacccagcc   6420

cgtgtaagaa cagaaggctc acctgcagtg gctgaccacc ctacccaact cggttagtgt   6480

ctcaccaatt tgttactata aacatttgca ccccaca                            6517


<210>  2403
<211>  1235
<212>  PRT
<213>  Homo sapiens

<400>  2403


Met Asp Gly Pro Thr Arg Gly His Gly Leu Arg Lys Lys Arg Arg Ser 
1               5                   10                  15      


Arg Ser Gln Arg Asp Arg Glu Arg Arg Ser Arg Gly Gly Leu Gly Ala 
            20                  25                  30          


Gly Ala Ala Gly Gly Gly Gly Ala Gly Arg Thr Arg Ala Leu Ser Leu 
        35                  40                  45              


Ala Ser Ser Ser Gly Ser Asp Lys Glu Asp Asn Gly Lys Pro Pro Ser 
    50                  55                  60                  


Ser Ala Pro Ser Arg Pro Arg Pro Pro Arg Arg Lys Arg Arg Glu Ser 
65                  70                  75                  80  


Thr Ser Ala Glu Glu Asp Ile Ile Asp Gly Phe Ala Met Thr Ser Phe 
                85                  90                  95      


Val Thr Phe Glu Ala Leu Glu Lys Asp Val Ala Leu Lys Pro Gln Glu 
            100                 105                 110         


Arg Val Glu Lys Arg Gln Thr Pro Leu Thr Lys Lys Lys Arg Glu Ala 
        115                 120                 125             


Leu Thr Asn Gly Leu Ser Phe His Ser Lys Lys Ser Arg Leu Ser His 
    130                 135                 140                 


Pro His His Tyr Ser Ser Asp Arg Glu Asn Asp Arg Asn Leu Cys Gln 
145                 150                 155                 160 


His Leu Gly Lys Arg Lys Lys Met Pro Lys Ala Leu Arg Gln Leu Lys 
                165                 170                 175     


Pro Gly Gln Asn Ser Cys Arg Asp Ser Asp Ser Glu Ser Ala Ser Gly 
            180                 185                 190         


Glu Ser Lys Gly Phe His Arg Ser Ser Ser Arg Glu Arg Leu Ser Asp 
        195                 200                 205             


Ser Ser Ala Pro Ser Ser Leu Gly Thr Gly Tyr Phe Cys Asp Ser Asp 
    210                 215                 220                 


Ser Asp Gln Glu Glu Lys Ala Ser Asp Ala Ser Ser Glu Lys Leu Phe 
225                 230                 235                 240 


Asn Thr Val Ile Val Asn Lys Asp Pro Glu Leu Gly Val Gly Thr Leu 
                245                 250                 255     


Pro Glu His Asp Ser Gln Asp Ala Gly Pro Ile Val Pro Lys Ile Ser 
            260                 265                 270         


Gly Leu Glu Arg Ser Gln Glu Lys Ser Gln Asp Cys Cys Lys Glu Pro 
        275                 280                 285             


Ile Phe Glu Pro Val Val Leu Lys Asp Pro Cys Pro Gln Val Ala Gln 
    290                 295                 300                 


Pro Ile Pro Gln Pro Gln Thr Glu Pro Gln Leu Arg Ala Pro Ser Pro 
305                 310                 315                 320 


Asp Pro Asp Leu Val Gln Arg Thr Glu Ala Pro Pro Gln Pro Pro Pro 
                325                 330                 335     


Leu Ser Thr Gln Pro Pro Gln Gly Pro Pro Glu Ala Gln Leu Gln Pro 
            340                 345                 350         


Ala Pro Gln Pro Gln Val Gln Arg Pro Pro Arg Pro Gln Ser Pro Thr 
        355                 360                 365             


Gln Leu Leu His Gln Asn Leu Pro Pro Val Gln Ala His Pro Ser Ala 
    370                 375                 380                 


Gln Ser Leu Ser Gln Pro Leu Ser Ala Tyr Asn Ser Ser Ser Leu Ser 
385                 390                 395                 400 


Leu Asn Ser Leu Ser Ser Ser Arg Ser Ser Thr Pro Ala Lys Thr Gln 
                405                 410                 415     


Pro Ala Pro Pro His Ile Ser His His Pro Ser Ala Ser Pro Phe Pro 
            420                 425                 430         


Leu Ser Leu Pro Asn His Ser Pro Leu His Ser Phe Thr Pro Thr Leu 
        435                 440                 445             


Gln Pro Pro Ala His Ser His His Pro Asn Met Phe Ala Pro Pro Thr 
    450                 455                 460                 


Ala Leu Pro Pro Pro Pro Pro Leu Thr Ser Gly Ser Leu Gln Val Ala 
465                 470                 475                 480 


Gly His Pro Ala Gly Ser Thr Tyr Ser Glu Gln Asp Ile Leu Arg Gln 
                485                 490                 495     


Glu Leu Asn Thr Arg Phe Leu Ala Ser Gln Ser Ala Asp Arg Gly Ala 
            500                 505                 510         


Ser Leu Gly Pro Pro Pro Tyr Leu Arg Thr Glu Phe His Gln His Gln 
        515                 520                 525             


His Gln His Gln His Thr His Gln His Thr His Gln His Thr Phe Thr 
    530                 535                 540                 


Pro Phe Pro His Ala Ile Pro Pro Thr Ala Ile Met Pro Thr Pro Ala 
545                 550                 555                 560 


Pro Pro Met Phe Asp Lys Tyr Pro Thr Lys Val Asp Pro Phe Tyr Arg 
                565                 570                 575     


His Ser Leu Phe His Ser Tyr Pro Pro Ala Val Ser Gly Ile Pro Pro 
            580                 585                 590         


Met Ile Pro Pro Thr Gly Pro Phe Gly Ser Leu Gln Gly Ala Phe Gln 
        595                 600                 605             


Pro Lys Leu Thr Asp Pro Phe Arg Pro Met Leu Arg Lys Pro Gly Lys 
    610                 615                 620                 


Trp Cys Ala Met His Val His Ile Ala Trp Gln Ile Tyr His His Gln 
625                 630                 635                 640 


Gln Lys Val Lys Lys Gln Met Gln Ser Asp Pro His Lys Leu Asp Phe 
                645                 650                 655     


Gly Leu Lys Pro Glu Phe Leu Ser Arg Pro Pro Gly Pro Ser Leu Phe 
            660                 665                 670         


Gly Ala Ile His His Pro His Asp Leu Ala Arg Pro Ser Thr Leu Phe 
        675                 680                 685             


Ser Ala Ala Gly Ala Ala His Pro Thr Gly Thr Pro Phe Gly Pro Pro 
    690                 695                 700                 


Pro His His Ser Asn Phe Leu Asn Pro Ala Ala His Leu Glu Pro Phe 
705                 710                 715                 720 


Asn Arg Pro Ser Thr Phe Thr Gly Leu Ala Ala Val Gly Gly Asn Ala 
                725                 730                 735     


Phe Gly Gly Leu Gly Asn Pro Ser Val Thr Pro Asn Ser Met Phe Gly 
            740                 745                 750         


His Lys Asp Gly Pro Ser Val Gln Asn Phe Ser Asn Pro His Glu Pro 
        755                 760                 765             


Trp Asn Arg Leu His Arg Thr Pro Pro Ser Phe Pro Thr Pro Pro Pro 
    770                 775                 780                 


Trp Leu Lys Pro Gly Glu Leu Glu Arg Ser Ala Ser Ala Ala Ala His 
785                 790                 795                 800 


Asp Arg Asp Arg Asp Val Asp Lys Arg Asp Ser Ser Val Ser Lys Asp 
                805                 810                 815     


Asp Lys Glu Arg Glu Ser Val Glu Lys Arg His Ser Ser His Pro Ser 
            820                 825                 830         


Pro Ala Pro Val Leu Pro Val Asn Ala Leu Gly His Thr Arg Ser Ser 
        835                 840                 845             


Thr Glu Gln Ile Arg Ala His Leu Asn Thr Glu Ala Arg Glu Lys Asp 
    850                 855                 860                 


Lys Pro Lys Glu Arg Glu Arg Asp His Ser Glu Ser Arg Lys Asp Leu 
865                 870                 875                 880 


Ala Ala Asp Glu His Lys Ala Lys Glu Gly His Leu Pro Glu Lys Asp 
                885                 890                 895     


Gly His Gly His Glu Gly Arg Ala Ala Gly Glu Glu Ala Lys Gln Leu 
            900                 905                 910         


Ala Arg Val Pro Ser Pro Tyr Val Arg Thr Pro Val Val Glu Ser Ala 
        915                 920                 925             


Arg Pro Asn Ser Thr Ser Ser Arg Glu Ala Glu Pro Arg Lys Gly Glu 
    930                 935                 940                 


Pro Ala Tyr Glu Asn Pro Lys Lys Ser Ser Glu Val Lys Val Lys Glu 
945                 950                 955                 960 


Glu Arg Lys Glu Asp His Asp Leu Pro Pro Glu Ala Pro Gln Thr His 
                965                 970                 975     


Arg Ala Ser Glu Pro Pro Pro Pro Asn Ser Ser Ser Ser Val His Pro 
            980                 985                 990         


Gly Pro Leu Ala Ser Met Pro Met  Thr Val Gly Val Thr  Gly Ile His 
        995                 1000                 1005             


Pro Met  Asn Ser Ile Ser Ser  Leu Asp Arg Thr Arg  Met Met Thr 
    1010                 1015                 1020             


Pro Phe  Met Gly Ile Ser Pro  Leu Pro Gly Gly Glu  Arg Phe Pro 
    1025                 1030                 1035             


Tyr Pro  Ser Phe His Trp Asp  Pro Ile Arg Asp Pro  Leu Arg Asp 
    1040                 1045                 1050             


Pro Tyr  Arg Glu Leu Asp Ile  His Arg Arg Asp Pro  Leu Gly Arg 
    1055                 1060                 1065             


Asp Phe  Leu Leu Arg Asn Asp  Pro Leu His Arg Leu  Ser Thr Pro 
    1070                 1075                 1080             


Arg Leu  Tyr Glu Ala Asp Arg  Ser Phe Arg Asp Arg  Glu Pro His 
    1085                 1090                 1095             


Asp Tyr  Ser His His His His  His His His His Pro  Leu Ser Val 
    1100                 1105                 1110             


Asp Pro  Arg Arg Glu His Glu  Arg Gly Gly His Leu  Asp Glu Arg 
    1115                 1120                 1125             


Glu Arg  Leu His Met Leu Arg  Glu Asp Tyr Glu His  Thr Arg Leu 
    1130                 1135                 1140             


His Ser  Val His Pro Ala Ser  Leu Asp Gly His Leu  Pro His Pro 
    1145                 1150                 1155             


Ser Leu  Ile Thr Pro Gly Leu  Pro Ser Met His Tyr  Pro Arg Ile 
    1160                 1165                 1170             


Ser Pro  Thr Ala Gly Asn Gln  Asn Gly Leu Leu Asn  Lys Thr Pro 
    1175                 1180                 1185             


Pro Thr  Ala Ala Leu Ser Ala  Pro Pro Pro Leu Ile  Ser Thr Leu 
    1190                 1195                 1200             


Gly Gly  Arg Pro Val Ser Pro  Arg Arg Thr Thr Pro  Leu Ser Ala 
    1205                 1210                 1215             


Glu Ile  Arg Glu Arg Pro Pro  Ser His Thr Leu Lys  Asp Ile Glu 
    1220                 1225                 1230             


Ala Arg  
    1235 

<210>  2404
<211>  6589
<212>  DNA
<213>  Homo sapiens

<400>  2404
cgctcgcagt ttcgccctct cttccgctaa tgattgcatt attatgctcc cctctctggg     60

gggtctcgcc cctcttgggt cgctccggag ccccggcctc ccctggctgc atttcttaaa    120

aatttgggag cctgggagtg agttttctcc gaggcgtgtg tgagaggcgg cgggggtgtt    180

ttcctgcgcg aggggcgggt gaagttcatt gcccccactt ttcccgcgac ctttttcgga    240

cccgattttg gatcgagttg aggggggcgc gggcgttttc ggggggcggg gggcgcggcg    300

gagaatggcc gcggggaggg ctccccggag cctcccagtc tcttgatcaa agcattccgc    360

tattctgatt tattgcttgc ttggtgagtt attttttttt cctctaaagg agacctgtgt    420

gttcagccat tactttgctc ggcgctgctc ccaggcatct ccgaccctcg gtgctgtggg    480

gagccccaca cttgggctcc tcgcctctcg ccctcgctcc ccgtccctcc tcccctctct    540

ccgccccttc ccccttttct ttctcctctc tttcttcccc tctctccctt ctttcggccg    600

ccgtctcccc cgcgccctcc tcggggcgga gggaagccgt gaagggggag ggagggctcg    660

gtgtcaattt ttttttgtgt ggctgcggcc gtagcctgtg gcgggcaagc ggggagaccc    720

cggcgcagca gaaccatgga tggcccgacg cggggccatg gactccgcaa aaagcggcgg    780

tcgcggtcgc agcgagaccg ggagaggcgc tcccggggcg ggctgggggc cggcgcggcc    840

ggcggcggcg gggctggccg gacccgggcg ctctcactcg cctcgtcgtc gggctccgac    900

aaggaagaca atgggaagcc cccgtcctcc gccccgtccc ggcccagacc cccgcggagg    960

aagcggagag agtccacctc ggcagaagag gacatcattg atggatttgc catgaccagc   1020

tttgtcactt ttgaagcgct ggagaaagat gtagcactta agcctcagga acgtgtggag   1080

aaacgccaga cgcccctgac caagaagaaa cgagaagcac ttaccaatgg cttgtccttt   1140

cattcaaaga agagcagact cagccaccca caccactaca gctcagatcg agaaaatgac   1200

cgcaatctct gccagcacct tgggaagaga aagaaaatgc cgaaggcact cagacagctc   1260

aagccaggac agaacagctg cagggacagt gacagtgaaa gtgccagtgg agaatccaag   1320

ggcttccacc ggagcagctc tcgggaaagg ctcagtgata gttcagctcc ttccagcttg   1380

ggaacaggct acttctgtga cagtgacagt gaccaggaag agaaggcatc agatgccagc   1440

tctgaaaaac tcttcaacac tgttattgta aacaaagatc cggagttagg tgttggcacg   1500

ctaccagaac atgacagcca ggatgcaggg ccgattgtcc ccaagatatc gggtctagag   1560

agaagccagg agaagagcca ggactgttgc aaagagccaa tctttgagcc tgtggtgctt   1620

aaagacccct gccctcaggt cgcacagcca ataccccagc cgcagacgga gccccaactc   1680

cgagctcctt ctccggaccc tgacttggtg cagcgcacag aggccccacc tcaaccccca   1740

cctctgagta cacagccacc acagggccct cctgaggccc agctccagcc tgccccgcag   1800

cctcaggtgc agaggccacc caggccacag tcccccaccc agctgctcca tcagaacctc   1860

ccacctgtgc aggcccaccc ctctgctcag agcctctccc agccattgtc agcctacaac   1920

agcagtagct taagcctcaa cagtttaagc agcagcagaa gcagcactcc agcgaagact   1980

cagcccgccc cacctcacat ctcccaccac ccctctgcct ccccgttccc cctctccctg   2040

cccaaccaca gccccctgca cagcttcaca cccaccctcc agccccccgc acactcacat   2100

caccccaata tgtttgcccc tcccactgct ctgcctcctc caccaccact gacatcagga   2160

agtctgcagg tggccggaca cccggccggg agcacttact cagagcaaga catcttgcga   2220

caggaactga acactcgttt tttggcctct cagagtgctg accgcggggc ttccctgggc   2280

cctccgccct acctgcggac cgagttccat cagcaccagc accagcacca gcacacccac   2340

cagcacacgc accagcacac cttcacgccg ttcccccacg ccatcccacc caccgccatc   2400

atgccgacgc cagcacctcc catgtttgac aaatacccta caaaagttga cccattctac   2460

cggcacagtc tcttccattc ctatcctcct gcagtgtcgg gcatcccccc tatgatccca   2520

cccactggcc cttttggttc actacaagga gcatttcagc cgaagacatc caaccctatc   2580

gatgtcgctg ctcggcctgg gacagtccca cacactttac tccaaaagga cccgaggttg   2640

acagatcctt tcagacctat gttaaggaaa ccagggaagt ggtgtgctat gcatgttcac   2700

atcgcctggc agatttacca ccaccaacag aaagtcaaga aacagatgca gtcagaccca   2760

cataagctgg actttggact gaaacctgag ttcctgagcc gccctccagg ccccagtctt   2820

tttggagcca tccaccaccc ccatgacctg gcacggcctt caactttgtt ctctgccgct   2880

ggtgctgcac acccaactgg gacccctttt gggccacctc ctcatcacag caacttcctc   2940

aaccctgctg cccacctaga gccttttaat cggccgtcta cattcacagg cctagcagca   3000

gttggtggca atgccttcgg gggacttgga aatccttccg ttacacccaa ctcaatgttc   3060

ggccacaagg atggccccag tgtgcagaac tttagcaacc ctcacgaacc ctggaaccgg   3120

ctgcaccgaa cgcctccgtc gttcccgacc cctccgccct ggctgaagcc aggggagctg   3180

gagcgcagcg cgtccgctgc agctcatgac agagatagag atgtagataa acgagactca   3240

tctgttagta aagatgacaa agaaagggaa agcgtcgaga agagacactc cagccaccct   3300

tcaccagcac ctgtcctccc ggtgaatgcc ctgggacata cccgcagctc cactgaacag   3360

atccgggctc atctgaacac tgaggctcgg gagaaggaca aacccaaaga gagggagaga   3420

gaccactcgg aatcccgcaa ggacctggcc gccgacgagc acaaggcgaa agagggccac   3480

ctgcccgaga aggacgggca cggccacgag gggcgcgccg cgggcgaaga ggccaagcag   3540

ctggcccggg tgccgtctcc ctacgtgcgg accccggtgg tggagagtgc caggcccaac   3600

agcacctcga gccgggaggc cgagccgcgc aagggtgagc cggcctacga gaaccccaag   3660

aagagctccg aggtcaaggt gaaggaggag cggaaggaag accatgacct gcctccagag   3720

gccccgcaga cccaccgggc ctcggagccg ccgcctccca actcctcgtc cagcgtgcac   3780

ccggggcccc tggcctcgat gcccatgacg gtgggggtga cgggcattca ccccatgaac   3840

agcatcagca gcctggacag gactcgcatg atgaccccct tcatgggcat cagccccctc   3900

ccgggcggag agcgcttccc gtacccttct ttccactggg accccatccg ggaccccttg   3960

agggatcctt accgagaact tgacattcac cggagagacc cgctgggcag ggacttcctg   4020

ctaaggaacg acccgctcca ccggctctcg actccccggc tgtacgaagc cgaccgctcc   4080

ttcagggacc gggagcctca cgactacagc caccaccacc accaccacca ccacccgctg   4140

tctgtggacc ctcggcggga gcacgagcgg ggaggccacc tggacgagcg ggagcgcttg   4200

cacatgctca gagaagacta cgagcacacg cggctccact ccgtgcaccc cgcctccctc   4260

gacggacacc tcccccaccc cagcctcatc accccgggac tccccagcat gcactatccc   4320

cgcatcagcc ccaccgcggg caaccagaac ggactcctca acaagacccc tccgacagca   4380

gcgctgagcg cacctccccc gctcatctcc acgctggggg gccgcccggt ctctcccaga   4440

aggacgactc ctctgtccgc agagataagg gagaggcccc cttcccacac gctgaaggat   4500

atcgaggccc gataagccga gaacaggagc aagaacgagg aagaagaaac cctaggcaga   4560

caccaggcca ggcttgagag acagaactcc tgcatggctc acacagactg ggggggaaag   4620

ccccacccct tccccttgta aaaaatgtat agactcagtg cacattttga aatgttttgt   4680

atattatatg ttgagatttt tcagatcttt tagcccagtc atatgttctc acgtctccta   4740

ctttttgttt ctcgtataaa actttttgat ttgaaccaaa acagtgaaga tgacaacaca   4800

caccaattgg atgataattg tagcgggggc ggtggggggg agaagtccac gccatccatc   4860

atgcaaaatt ctttcagatg aggtgggaag gccgtgtaca tagttatgta aaaagagatt   4920

gcttcatgag ctaatggttc atatatgcaa aagggtaaga tgaaagcttt actttgtaca   4980

aatgtaaata gataaagtaa cataatacat taatacttct taaaatgtgc tatttgcaaa   5040

cttacttaat atcagtgaac acagtcggct aaagctgtgt tcccatatat tgttatagac   5100

agctaaaccc ttcaactatg caatgaatgt tcgggctttt cacaaaagcc cgcctaactc   5160

aaaggagcct tttcaaatcc atttacagca tacttaaggt catattttcc ctgaacaagc   5220

gcttacgtga tatgactctg ttttccttgc ttgttttttt tcaaacggag aaacatcctg   5280

ttttgcaaat tggaccccag gctggaactt agcatctgaa gttgccgctt gtgggctctg   5340

ggggaaagtg tagccccgga gaggtaactg aggacatgag caaccagtgc cagggagggt   5400

gggatttgcc agatgccaaa atcaggggac gggtggtggt gtctgtcaga cacacacagg   5460

tcgccagtga cttcacacac acctcatgtg agaaccatgc cttttttagt gtgtcctatt   5520

tcatacctgt acacacttcc tcgttttgta atgagattta cttacaccca aacagatcct   5580

gaaagaaagc ttcaagtttt ctcagatgat ggatatgttt tcactgtatt caataactga   5640

cggatgtaag gtgcacgttt cctgatgtga cgcactgtat tccagctggt gatcaagtct   5700

gggaacagcc gtaacaggtc aaccttgtgg agccatcgcg agttagaggg tgaaagatgg   5760

cagaaaaaaa agtcttgtgt gtgagtgtgt tttttgagtt tgcatcaatc ttaatgtctc   5820

ttcataatac ttttataata cattaagcct cttgtctaca tatttggaga gaatatgact   5880

ttactagcag agaaatacaa tatatcttgt ctactggact gtaaaatata tgtatgaaat   5940

aaaattagtt ccatttggtc ttctagtata ttaaagtgct atctgacgtt gttatcctgt   6000

ttttgcaaaa aaaaaaaaaa aaaaaagtta actacagacc attgtttcta ataagcagag   6060

agatctattt tagtagtaaa ctgaaggttt agttgtgagc ttcagatttt gtgaactcca   6120

gatgttgtgc ggtgtttttt ttttttttta agacaacaac taaaaaaaat gcaaggaata   6180

tgtacactgg aactgtagtg gtagctttca gtattgtaaa gagattgttc tatacggacc   6240

tttttgctgt ttatcctgta tgtaataaag tcctttctag atcctatgtg aaaagaaaag   6300

tgaagcaact gaatcttcag catgttctca tcggcggagc cttcttgtgt aatgtaaact   6360

gtgccatgtt attaaaaaat gtgaactaag cttccagctg cttgtttgtg tgaggtgacc   6420

atcattacct tagggaagaa gccatacctg tacaagaccg ggctcttgaa aagaaacacc   6480

tcgaacccag cccgtgtaag aacagaaggc tcacctgcag tggctgacca ccctacccaa   6540

ctcggttagt gtctcaccaa tttgttacta taaacatttg caccccaca               6589


<210>  2405
<211>  1259
<212>  PRT
<213>  Homo sapiens

<400>  2405


Met Asp Gly Pro Thr Arg Gly His Gly Leu Arg Lys Lys Arg Arg Ser 
1               5                   10                  15      


Arg Ser Gln Arg Asp Arg Glu Arg Arg Ser Arg Gly Gly Leu Gly Ala 
            20                  25                  30          


Gly Ala Ala Gly Gly Gly Gly Ala Gly Arg Thr Arg Ala Leu Ser Leu 
        35                  40                  45              


Ala Ser Ser Ser Gly Ser Asp Lys Glu Asp Asn Gly Lys Pro Pro Ser 
    50                  55                  60                  


Ser Ala Pro Ser Arg Pro Arg Pro Pro Arg Arg Lys Arg Arg Glu Ser 
65                  70                  75                  80  


Thr Ser Ala Glu Glu Asp Ile Ile Asp Gly Phe Ala Met Thr Ser Phe 
                85                  90                  95      


Val Thr Phe Glu Ala Leu Glu Lys Asp Val Ala Leu Lys Pro Gln Glu 
            100                 105                 110         


Arg Val Glu Lys Arg Gln Thr Pro Leu Thr Lys Lys Lys Arg Glu Ala 
        115                 120                 125             


Leu Thr Asn Gly Leu Ser Phe His Ser Lys Lys Ser Arg Leu Ser His 
    130                 135                 140                 


Pro His His Tyr Ser Ser Asp Arg Glu Asn Asp Arg Asn Leu Cys Gln 
145                 150                 155                 160 


His Leu Gly Lys Arg Lys Lys Met Pro Lys Ala Leu Arg Gln Leu Lys 
                165                 170                 175     


Pro Gly Gln Asn Ser Cys Arg Asp Ser Asp Ser Glu Ser Ala Ser Gly 
            180                 185                 190         


Glu Ser Lys Gly Phe His Arg Ser Ser Ser Arg Glu Arg Leu Ser Asp 
        195                 200                 205             


Ser Ser Ala Pro Ser Ser Leu Gly Thr Gly Tyr Phe Cys Asp Ser Asp 
    210                 215                 220                 


Ser Asp Gln Glu Glu Lys Ala Ser Asp Ala Ser Ser Glu Lys Leu Phe 
225                 230                 235                 240 


Asn Thr Val Ile Val Asn Lys Asp Pro Glu Leu Gly Val Gly Thr Leu 
                245                 250                 255     


Pro Glu His Asp Ser Gln Asp Ala Gly Pro Ile Val Pro Lys Ile Ser 
            260                 265                 270         


Gly Leu Glu Arg Ser Gln Glu Lys Ser Gln Asp Cys Cys Lys Glu Pro 
        275                 280                 285             


Ile Phe Glu Pro Val Val Leu Lys Asp Pro Cys Pro Gln Val Ala Gln 
    290                 295                 300                 


Pro Ile Pro Gln Pro Gln Thr Glu Pro Gln Leu Arg Ala Pro Ser Pro 
305                 310                 315                 320 


Asp Pro Asp Leu Val Gln Arg Thr Glu Ala Pro Pro Gln Pro Pro Pro 
                325                 330                 335     


Leu Ser Thr Gln Pro Pro Gln Gly Pro Pro Glu Ala Gln Leu Gln Pro 
            340                 345                 350         


Ala Pro Gln Pro Gln Val Gln Arg Pro Pro Arg Pro Gln Ser Pro Thr 
        355                 360                 365             


Gln Leu Leu His Gln Asn Leu Pro Pro Val Gln Ala His Pro Ser Ala 
    370                 375                 380                 


Gln Ser Leu Ser Gln Pro Leu Ser Ala Tyr Asn Ser Ser Ser Leu Ser 
385                 390                 395                 400 


Leu Asn Ser Leu Ser Ser Ser Arg Ser Ser Thr Pro Ala Lys Thr Gln 
                405                 410                 415     


Pro Ala Pro Pro His Ile Ser His His Pro Ser Ala Ser Pro Phe Pro 
            420                 425                 430         


Leu Ser Leu Pro Asn His Ser Pro Leu His Ser Phe Thr Pro Thr Leu 
        435                 440                 445             


Gln Pro Pro Ala His Ser His His Pro Asn Met Phe Ala Pro Pro Thr 
    450                 455                 460                 


Ala Leu Pro Pro Pro Pro Pro Leu Thr Ser Gly Ser Leu Gln Val Ala 
465                 470                 475                 480 


Gly His Pro Ala Gly Ser Thr Tyr Ser Glu Gln Asp Ile Leu Arg Gln 
                485                 490                 495     


Glu Leu Asn Thr Arg Phe Leu Ala Ser Gln Ser Ala Asp Arg Gly Ala 
            500                 505                 510         


Ser Leu Gly Pro Pro Pro Tyr Leu Arg Thr Glu Phe His Gln His Gln 
        515                 520                 525             


His Gln His Gln His Thr His Gln His Thr His Gln His Thr Phe Thr 
    530                 535                 540                 


Pro Phe Pro His Ala Ile Pro Pro Thr Ala Ile Met Pro Thr Pro Ala 
545                 550                 555                 560 


Pro Pro Met Phe Asp Lys Tyr Pro Thr Lys Val Asp Pro Phe Tyr Arg 
                565                 570                 575     


His Ser Leu Phe His Ser Tyr Pro Pro Ala Val Ser Gly Ile Pro Pro 
            580                 585                 590         


Met Ile Pro Pro Thr Gly Pro Phe Gly Ser Leu Gln Gly Ala Phe Gln 
        595                 600                 605             


Pro Lys Thr Ser Asn Pro Ile Asp Val Ala Ala Arg Pro Gly Thr Val 
    610                 615                 620                 


Pro His Thr Leu Leu Gln Lys Asp Pro Arg Leu Thr Asp Pro Phe Arg 
625                 630                 635                 640 


Pro Met Leu Arg Lys Pro Gly Lys Trp Cys Ala Met His Val His Ile 
                645                 650                 655     


Ala Trp Gln Ile Tyr His His Gln Gln Lys Val Lys Lys Gln Met Gln 
            660                 665                 670         


Ser Asp Pro His Lys Leu Asp Phe Gly Leu Lys Pro Glu Phe Leu Ser 
        675                 680                 685             


Arg Pro Pro Gly Pro Ser Leu Phe Gly Ala Ile His His Pro His Asp 
    690                 695                 700                 


Leu Ala Arg Pro Ser Thr Leu Phe Ser Ala Ala Gly Ala Ala His Pro 
705                 710                 715                 720 


Thr Gly Thr Pro Phe Gly Pro Pro Pro His His Ser Asn Phe Leu Asn 
                725                 730                 735     


Pro Ala Ala His Leu Glu Pro Phe Asn Arg Pro Ser Thr Phe Thr Gly 
            740                 745                 750         


Leu Ala Ala Val Gly Gly Asn Ala Phe Gly Gly Leu Gly Asn Pro Ser 
        755                 760                 765             


Val Thr Pro Asn Ser Met Phe Gly His Lys Asp Gly Pro Ser Val Gln 
    770                 775                 780                 


Asn Phe Ser Asn Pro His Glu Pro Trp Asn Arg Leu His Arg Thr Pro 
785                 790                 795                 800 


Pro Ser Phe Pro Thr Pro Pro Pro Trp Leu Lys Pro Gly Glu Leu Glu 
                805                 810                 815     


Arg Ser Ala Ser Ala Ala Ala His Asp Arg Asp Arg Asp Val Asp Lys 
            820                 825                 830         


Arg Asp Ser Ser Val Ser Lys Asp Asp Lys Glu Arg Glu Ser Val Glu 
        835                 840                 845             


Lys Arg His Ser Ser His Pro Ser Pro Ala Pro Val Leu Pro Val Asn 
    850                 855                 860                 


Ala Leu Gly His Thr Arg Ser Ser Thr Glu Gln Ile Arg Ala His Leu 
865                 870                 875                 880 


Asn Thr Glu Ala Arg Glu Lys Asp Lys Pro Lys Glu Arg Glu Arg Asp 
                885                 890                 895     


His Ser Glu Ser Arg Lys Asp Leu Ala Ala Asp Glu His Lys Ala Lys 
            900                 905                 910         


Glu Gly His Leu Pro Glu Lys Asp Gly His Gly His Glu Gly Arg Ala 
        915                 920                 925             


Ala Gly Glu Glu Ala Lys Gln Leu Ala Arg Val Pro Ser Pro Tyr Val 
    930                 935                 940                 


Arg Thr Pro Val Val Glu Ser Ala Arg Pro Asn Ser Thr Ser Ser Arg 
945                 950                 955                 960 


Glu Ala Glu Pro Arg Lys Gly Glu Pro Ala Tyr Glu Asn Pro Lys Lys 
                965                 970                 975     


Ser Ser Glu Val Lys Val Lys Glu Glu Arg Lys Glu Asp His Asp Leu 
            980                 985                 990         


Pro Pro Glu Ala Pro Gln Thr His  Arg Ala Ser Glu Pro  Pro Pro Pro 
        995                 1000                 1005             


Asn Ser  Ser Ser Ser Val His  Pro Gly Pro Leu Ala  Ser Met Pro 
    1010                 1015                 1020             


Met Thr  Val Gly Val Thr Gly  Ile His Pro Met Asn  Ser Ile Ser 
    1025                 1030                 1035             


Ser Leu  Asp Arg Thr Arg Met  Met Thr Pro Phe Met  Gly Ile Ser 
    1040                 1045                 1050             


Pro Leu  Pro Gly Gly Glu Arg  Phe Pro Tyr Pro Ser  Phe His Trp 
    1055                 1060                 1065             


Asp Pro  Ile Arg Asp Pro Leu  Arg Asp Pro Tyr Arg  Glu Leu Asp 
    1070                 1075                 1080             


Ile His  Arg Arg Asp Pro Leu  Gly Arg Asp Phe Leu  Leu Arg Asn 
    1085                 1090                 1095             


Asp Pro  Leu His Arg Leu Ser  Thr Pro Arg Leu Tyr  Glu Ala Asp 
    1100                 1105                 1110             


Arg Ser  Phe Arg Asp Arg Glu  Pro His Asp Tyr Ser  His His His 
    1115                 1120                 1125             


His His  His His His Pro Leu  Ser Val Asp Pro Arg  Arg Glu His 
    1130                 1135                 1140             


Glu Arg  Gly Gly His Leu Asp  Glu Arg Glu Arg Leu  His Met Leu 
    1145                 1150                 1155             


Arg Glu  Asp Tyr Glu His Thr  Arg Leu His Ser Val  His Pro Ala 
    1160                 1165                 1170             


Ser Leu  Asp Gly His Leu Pro  His Pro Ser Leu Ile  Thr Pro Gly 
    1175                 1180                 1185             


Leu Pro  Ser Met His Tyr Pro  Arg Ile Ser Pro Thr  Ala Gly Asn 
    1190                 1195                 1200             


Gln Asn  Gly Leu Leu Asn Lys  Thr Pro Pro Thr Ala  Ala Leu Ser 
    1205                 1210                 1215             


Ala Pro  Pro Pro Leu Ile Ser  Thr Leu Gly Gly Arg  Pro Val Ser 
    1220                 1225                 1230             


Pro Arg  Arg Thr Thr Pro Leu  Ser Ala Glu Ile Arg  Glu Arg Pro 
    1235                 1240                 1245             


Pro Ser  His Thr Leu Lys Asp  Ile Glu Ala Arg 
    1250                 1255                 

<210>  2406
<211>  3482
<212>  DNA
<213>  Homo sapiens

<400>  2406
aatttttgca ccattccagg caagttgatc ttataaggaa ataaaattga accttagggg     60

tctgatggaa attcactgtg acattcaaat caagaaaact tgctaatgcc cacagagcct    120

tttccccatg ggccctgatg gtagcctcca gaaggtgcag cctcaggtgg tgccctttct    180

tctgtggcaa gaataaactt tgggtcttgg attgcaatac cacctgtgga gaaaatggta    240

tgcgagggaa agcgatcagc ctcttgccct tgtttcttcc tcttgaccgc caagttctac    300

tggatcctca caatgatgca aagaactcac agccaggagt atgcccattc catacgggtg    360

gatggggaca ttattttggg gggtctcttc cctgtccacg caaagggaga gagaggggtg    420

ccttgtgggg agctgaagaa ggaaaagggg attcacagac tggaggccat gctttatgca    480

attgaccaga ttaacaagga ccctgatctc ctttccaaca tcactctggg tgtccgcatc    540

ctcgacacgt gctctaggga cacctatgct ttggagcagt ctctaacatt cgtgcaggca    600

ttaatagaga aagatgcttc ggatgtgaag tgtgctaatg gagatccacc cattttcacc    660

aagcccgaca agatttctgg cgtcataggt gctgcagcaa gctccgtgtc catcatggtt    720

gctaacattt taagactttt taagatacct caaatcagct atgcatccac agccccagag    780

ctaagtgata acaccaggta tgactttttc tctcgagtgg ttccgcctga ctcctaccaa    840

gcccaagcca tggtggacat cgtgacagca ctgggatgga attatgtttc gacactggct    900

tctgagggga actatggtga gagcggtgtg gaggccttca cccagatctc gagggagatt    960

ggtggtgttt gcattgctca gtcacagaaa atcccacgtg aaccaagacc tggagaattt   1020

gaaaaaatta tcaaacgcct gctagaaaca cctaatgctc gagcagtgat tatgtttgcc   1080

aatgaggatg acatcaggag gatattggaa gcagcaaaaa aactaaacca aagtgggcat   1140

tttctctgga ttggctcaga tagttgggga tccaaaatag cacctgtcta tcagcaagag   1200

gagattgcag aaggggctgt gacaattttg cccaaacgag catcaattga tggatttgat   1260

cgatacttta gaagccgaac tcttgccaat aatcgaagaa atgtgtggtt tgcagaattc   1320

tgggaggaga attttggctg caagttagga tcacatggga aaaggaacag tcatataaag   1380

aaatgcacag ggctggagcg aattgctcgg gattcatctt atgaacagga aggaaaggtc   1440

caatttgtaa ttgatgctgt atattccatg gcttacgccc tgcacaatat gcacaaagat   1500

ctctgccctg gatacattgg cctttgtcca cgaatgagta ccattgatgg gaaagagcta   1560

cttggttata ttcgggctgt aaattttaat ggcagtgctg gcactcctgt cacttttaat   1620

gaaaacggag atgctcctgg acgttatgat atcttccagt atcaaataac caacaaaagc   1680

acagagtaca aagtcatcgg ccactggacc aatcagcttc atctaaaagt ggaagacatg   1740

cagtgggctc atagagaaca tactcacccg gcgtctgtct gcagcctgcc gtgtaagcca   1800

ggggagagga agaaaacggt gaaaggggtc ccttgctgct ggcactgtga acgctgtgaa   1860

ggttacaact accaggtgga tgagctgtcc tgtgaacttt gccctctgga tcagagaccc   1920

aacatgaacc gcacaggctg ccagcttatc cccatcatca aattggagtg gcattctccc   1980

tgggctgtgg tgcctgtgtt tgttgcaata ttgggaatca tcgccaccac ctttgtgatc   2040

gtgacctttg tccgctataa tgacacacct atcgtgaggg cttcaggacg cgaacttagt   2100

tacgtgctcc taacggggat ttttctctgt tattcaatca cgtttttaat gattgcagca   2160

ccagatacaa tcatatgctc cttccgacgg gtcttcctag gacttggcat gtgtttcagc   2220

tatgcagccc ttctgaccaa aacaaaccgt atccaccgaa tatttgagca ggggaagaaa   2280

tctgtcacag cgcccaagtt cattagtcca gcatctcagc tggtgatcac cttcagcctc   2340

atctccgtcc agctccttgg agtgtttgtc tggtttgttg tggatccccc ccacatcatc   2400

attgactatg gagagcagcg gacactagat ccagagaagg ccaggggagt gctcaagtgt   2460

gacatttctg atctctcact catttgttca cttggataca gtatcctctt gatggtcact   2520

tgtactgttt atgccattaa aacgagaggt gtcccagaga ctttcaatga agccaaacct   2580

attggattta ccatgtatac cacctgcatc atttggttag ctttcatccc catctttttt   2640

ggtacagccc agtcagcaga aaagatgtac atccagacaa caacacttac tgtctccatg   2700

agtttaagtg cttcagtatc tctgggcatg ctctatatgc ccaaggttta tattataatt   2760

tttcatccag aacagaatgt tcaaaaacgc aagaggagct tcaaggctgt ggtgacagct   2820

gccaccatgc aaagcaaact gatccaaaaa ggaaatgaca gaccaaatgg cgaggtgaaa   2880

agtgaactct gtgagagtct tgaaaccaac acttcctcta ccaagacaac atatatcagt   2940

tacagcaatc attcaatctg aaacagggaa atggcacaat ctgaagagat gtggtatatg   3000

atcttaaatg atgaacatga gaccgcaaaa attcactcct ggagatctcc gtagactaca   3060

atcaatcaaa tcaatagtca gtcttgtaag gaacaaaaat tagccatgag ccaaaagtat   3120

caataaacgg ggagtgaaga aacccgtttt atacaataaa accaatgagt gtcaagctaa   3180

agtattgctt attcatgagc agttaaaaca aatcacaaaa ggaaaactaa tgttagctcg   3240

tgaaaaaaaa tgctgttgaa ataaataatg tctgatgtta ttcttgtatt tttctgtgat   3300

tgtgagaact cccgttcctg tcccacattg tttaacttgt ataagacaat gagtctgttt   3360

cttgtaatgg ctgaccagat tgaagccctg ggttgtgcta aaaataaatg caatgattga   3420

tgcatgcaat tttttataca aataatttat ttctaataat aaaggaatgt tttgcaaatg   3480

tt                                                                  3482


<210>  2407
<211>  908
<212>  PRT
<213>  Homo sapiens

<400>  2407


Met Val Cys Glu Gly Lys Arg Ser Ala Ser Cys Pro Cys Phe Phe Leu 
1               5                   10                  15      


Leu Thr Ala Lys Phe Tyr Trp Ile Leu Thr Met Met Gln Arg Thr His 
            20                  25                  30          


Ser Gln Glu Tyr Ala His Ser Ile Arg Val Asp Gly Asp Ile Ile Leu 
        35                  40                  45              


Gly Gly Leu Phe Pro Val His Ala Lys Gly Glu Arg Gly Val Pro Cys 
    50                  55                  60                  


Gly Glu Leu Lys Lys Glu Lys Gly Ile His Arg Leu Glu Ala Met Leu 
65                  70                  75                  80  


Tyr Ala Ile Asp Gln Ile Asn Lys Asp Pro Asp Leu Leu Ser Asn Ile 
                85                  90                  95      


Thr Leu Gly Val Arg Ile Leu Asp Thr Cys Ser Arg Asp Thr Tyr Ala 
            100                 105                 110         


Leu Glu Gln Ser Leu Thr Phe Val Gln Ala Leu Ile Glu Lys Asp Ala 
        115                 120                 125             


Ser Asp Val Lys Cys Ala Asn Gly Asp Pro Pro Ile Phe Thr Lys Pro 
    130                 135                 140                 


Asp Lys Ile Ser Gly Val Ile Gly Ala Ala Ala Ser Ser Val Ser Ile 
145                 150                 155                 160 


Met Val Ala Asn Ile Leu Arg Leu Phe Lys Ile Pro Gln Ile Ser Tyr 
                165                 170                 175     


Ala Ser Thr Ala Pro Glu Leu Ser Asp Asn Thr Arg Tyr Asp Phe Phe 
            180                 185                 190         


Ser Arg Val Val Pro Pro Asp Ser Tyr Gln Ala Gln Ala Met Val Asp 
        195                 200                 205             


Ile Val Thr Ala Leu Gly Trp Asn Tyr Val Ser Thr Leu Ala Ser Glu 
    210                 215                 220                 


Gly Asn Tyr Gly Glu Ser Gly Val Glu Ala Phe Thr Gln Ile Ser Arg 
225                 230                 235                 240 


Glu Ile Gly Gly Val Cys Ile Ala Gln Ser Gln Lys Ile Pro Arg Glu 
                245                 250                 255     


Pro Arg Pro Gly Glu Phe Glu Lys Ile Ile Lys Arg Leu Leu Glu Thr 
            260                 265                 270         


Pro Asn Ala Arg Ala Val Ile Met Phe Ala Asn Glu Asp Asp Ile Arg 
        275                 280                 285             


Arg Ile Leu Glu Ala Ala Lys Lys Leu Asn Gln Ser Gly His Phe Leu 
    290                 295                 300                 


Trp Ile Gly Ser Asp Ser Trp Gly Ser Lys Ile Ala Pro Val Tyr Gln 
305                 310                 315                 320 


Gln Glu Glu Ile Ala Glu Gly Ala Val Thr Ile Leu Pro Lys Arg Ala 
                325                 330                 335     


Ser Ile Asp Gly Phe Asp Arg Tyr Phe Arg Ser Arg Thr Leu Ala Asn 
            340                 345                 350         


Asn Arg Arg Asn Val Trp Phe Ala Glu Phe Trp Glu Glu Asn Phe Gly 
        355                 360                 365             


Cys Lys Leu Gly Ser His Gly Lys Arg Asn Ser His Ile Lys Lys Cys 
    370                 375                 380                 


Thr Gly Leu Glu Arg Ile Ala Arg Asp Ser Ser Tyr Glu Gln Glu Gly 
385                 390                 395                 400 


Lys Val Gln Phe Val Ile Asp Ala Val Tyr Ser Met Ala Tyr Ala Leu 
                405                 410                 415     


His Asn Met His Lys Asp Leu Cys Pro Gly Tyr Ile Gly Leu Cys Pro 
            420                 425                 430         


Arg Met Ser Thr Ile Asp Gly Lys Glu Leu Leu Gly Tyr Ile Arg Ala 
        435                 440                 445             


Val Asn Phe Asn Gly Ser Ala Gly Thr Pro Val Thr Phe Asn Glu Asn 
    450                 455                 460                 


Gly Asp Ala Pro Gly Arg Tyr Asp Ile Phe Gln Tyr Gln Ile Thr Asn 
465                 470                 475                 480 


Lys Ser Thr Glu Tyr Lys Val Ile Gly His Trp Thr Asn Gln Leu His 
                485                 490                 495     


Leu Lys Val Glu Asp Met Gln Trp Ala His Arg Glu His Thr His Pro 
            500                 505                 510         


Ala Ser Val Cys Ser Leu Pro Cys Lys Pro Gly Glu Arg Lys Lys Thr 
        515                 520                 525             


Val Lys Gly Val Pro Cys Cys Trp His Cys Glu Arg Cys Glu Gly Tyr 
    530                 535                 540                 


Asn Tyr Gln Val Asp Glu Leu Ser Cys Glu Leu Cys Pro Leu Asp Gln 
545                 550                 555                 560 


Arg Pro Asn Met Asn Arg Thr Gly Cys Gln Leu Ile Pro Ile Ile Lys 
                565                 570                 575     


Leu Glu Trp His Ser Pro Trp Ala Val Val Pro Val Phe Val Ala Ile 
            580                 585                 590         


Leu Gly Ile Ile Ala Thr Thr Phe Val Ile Val Thr Phe Val Arg Tyr 
        595                 600                 605             


Asn Asp Thr Pro Ile Val Arg Ala Ser Gly Arg Glu Leu Ser Tyr Val 
    610                 615                 620                 


Leu Leu Thr Gly Ile Phe Leu Cys Tyr Ser Ile Thr Phe Leu Met Ile 
625                 630                 635                 640 


Ala Ala Pro Asp Thr Ile Ile Cys Ser Phe Arg Arg Val Phe Leu Gly 
                645                 650                 655     


Leu Gly Met Cys Phe Ser Tyr Ala Ala Leu Leu Thr Lys Thr Asn Arg 
            660                 665                 670         


Ile His Arg Ile Phe Glu Gln Gly Lys Lys Ser Val Thr Ala Pro Lys 
        675                 680                 685             


Phe Ile Ser Pro Ala Ser Gln Leu Val Ile Thr Phe Ser Leu Ile Ser 
    690                 695                 700                 


Val Gln Leu Leu Gly Val Phe Val Trp Phe Val Val Asp Pro Pro His 
705                 710                 715                 720 


Ile Ile Ile Asp Tyr Gly Glu Gln Arg Thr Leu Asp Pro Glu Lys Ala 
                725                 730                 735     


Arg Gly Val Leu Lys Cys Asp Ile Ser Asp Leu Ser Leu Ile Cys Ser 
            740                 745                 750         


Leu Gly Tyr Ser Ile Leu Leu Met Val Thr Cys Thr Val Tyr Ala Ile 
        755                 760                 765             


Lys Thr Arg Gly Val Pro Glu Thr Phe Asn Glu Ala Lys Pro Ile Gly 
    770                 775                 780                 


Phe Thr Met Tyr Thr Thr Cys Ile Ile Trp Leu Ala Phe Ile Pro Ile 
785                 790                 795                 800 


Phe Phe Gly Thr Ala Gln Ser Ala Glu Lys Met Tyr Ile Gln Thr Thr 
                805                 810                 815     


Thr Leu Thr Val Ser Met Ser Leu Ser Ala Ser Val Ser Leu Gly Met 
            820                 825                 830         


Leu Tyr Met Pro Lys Val Tyr Ile Ile Ile Phe His Pro Glu Gln Asn 
        835                 840                 845             


Val Gln Lys Arg Lys Arg Ser Phe Lys Ala Val Val Thr Ala Ala Thr 
    850                 855                 860                 


Met Gln Ser Lys Leu Ile Gln Lys Gly Asn Asp Arg Pro Asn Gly Glu 
865                 870                 875                 880 


Val Lys Ser Glu Leu Cys Glu Ser Leu Glu Thr Asn Thr Ser Ser Thr 
                885                 890                 895     


Lys Thr Thr Tyr Ile Ser Tyr Ser Asn His Ser Ile 
            900                 905             

<210>  2408
<211>  3537
<212>  DNA
<213>  Homo sapiens

<400>  2408
aatttttgca ccattccagg caagttgatc ttataaggaa ataaaattga accttagggg     60

tctgatggaa attcactgtg acattcaaat caagaaaact tgctaatgcc cacagagcct    120

tttccccatg ggccctgatg gtagcctcca gaaggtgcag cctcaggtgg tgccctttct    180

tctgtggcaa gaataaactt tgggtcttgg attgcaatac cacctgtgga gaaaatggta    240

tgcgagggaa agcgatcagc ctcttgccct tgtttcttcc tcttgaccgc caagttctac    300

tggatcctca caatgatgca aagaactcac agccaggagt atgcccattc catacgggtg    360

gatggggaca ttattttggg gggtctcttc cctgtccacg caaagggaga gagaggggtg    420

ccttgtgggg agctgaagaa ggaaaagggg attcacagac tggaggccat gctttatgca    480

attgaccaga ttaacaagga ccctgatctc ctttccaaca tcactctggg tgtccgcatc    540

ctcgacacgt gctctaggga cacctatgct ttggagcagt ctctaacatt cgtgcaggca    600

ttaatagaga aagatgcttc ggatgtgaag tgtgctaatg gagatccacc cattttcacc    660

aagcccgaca agatttctgg cgtcataggt gctgcagcaa gctccgtgtc catcatggtt    720

gctaacattt taagactttt taagatacct caaatcagct atgcatccac agccccagag    780

ctaagtgata acaccaggta tgactttttc tctcgagtgg ttccgcctga ctcctaccaa    840

gcccaagcca tggtggacat cgtgacagca ctgggatgga attatgtttc gacactggct    900

tctgagggga actatggtga gagcggtgtg gaggccttca cccagatctc gagggagatt    960

ggtggtgttt gcattgctca gtcacagaaa atcccacgtg aaccaagacc tggagaattt   1020

gaaaaaatta tcaaacgcct gctagaaaca cctaatgctc gagcagtgat tatgtttgcc   1080

aatgaggatg acatcaggag gatattggaa gcagcaaaaa aactaaacca aagtgggcat   1140

tttctctgga ttggctcaga tagttgggga tccaaaatag cacctgtcta tcagcaagag   1200

gagattgcag aaggggctgt gacaattttg cccaaacgag catcaattga tggatttgat   1260

cgatacttta gaagccgaac tcttgccaat aatcgaagaa atgtgtggtt tgcagaattc   1320

tgggaggaga attttggctg caagttagga tcacatggga aaaggaacag tcatataaag   1380

aaatgcacag ggctggagcg aattgctcgg gattcatctt atgaacagga aggaaaggtc   1440

caatttgtaa ttgatgctgt atattccatg gcttacgccc tgcacaatat gcacaaagat   1500

ctctgccctg gatacattgg cctttgtcca cgaatgagta ccattgatgg gaaagagcta   1560

cttggttata ttcgggctgt aaattttaat ggcagtgctg gcactcctgt cacttttaat   1620

gaaaacggag atgctcctgg acgttatgat atcttccagt atcaaataac caacaaaagc   1680

acagagtaca aagtcatcgg ccactggacc aatcagcttc atctaaaagt ggaagacatg   1740

cagtgggctc atagagaaca tactcacccg gcgtctgtct gcagcctgcc gtgtaagcca   1800

ggggagagga agaaaacggt gaaaggggtc ccttgctgct ggcactgtga acgctgtgaa   1860

ggttacaact accaggtgga tgagctgtcc tgtgaacttt gccctctgga tcagagaccc   1920

aacatgaacc gcacaggctg ccagcttatc cccatcatca aattggagtg gcattctccc   1980

tgggctgtgg tgcctgtgtt tgttgcaata ttgggaatca tcgccaccac ctttgtgatc   2040

gtgacctttg tccgctataa tgacacacct atcgtgaggg cttcaggacg cgaacttagt   2100

tacgtgctcc taacggggat ttttctctgt tattcaatca cgtttttaat gattgcagca   2160

ccagatacaa tcatatgctc cttccgacgg gtcttcctag gacttggcat gtgtttcagc   2220

tatgcagccc ttctgaccaa aacaaaccgt atccaccgaa tatttgagca ggggaagaaa   2280

tctgtcacag cgcccaagtt cattagtcca gcatctcagc tggtgatcac cttcagcctc   2340

atctccgtcc agctccttgg agtgtttgtc tggtttgttg tggatccccc ccacatcatc   2400

attgactatg gagagcagcg gacactagat ccagagaagg ccaggggagt gctcaagtgt   2460

gacatttctg atctctcact catttgttca cttggataca gtatcctctt gatggtcact   2520

tgtactgttt atgccattaa aacgagaggt gtcccagaga ctttcaatga agccaaacct   2580

attggattta ccatgtatac cacctgcatc atttggttag ctttcatccc catctttttt   2640

ggtacagccc agtcagcaga aaagatgtac atccagacaa caacacttac tgtctccatg   2700

agtttaagtg cttcagtatc tctgggcatg ctctatatgc ccaaggttta tattataatt   2760

tttcatccag aacagaatgt tcaaaaacgc aagaggagct tcaaggctgt ggtgacagct   2820

gccaccatgc aaagcaaact gatccaaaaa ggaaatgaca gaccaaatgg cgaggtgaaa   2880

agtgaactct gtgagagtct tgaaaccaac agtaagtcat ctgtagagtt tccgatggtc   2940

aagagcggga gcacttccta atagatcttc ctctaccaag acaacatata tcagttacag   3000

caatcattca atctgaaaca gggaaatggc acaatctgaa gagatgtggt atatgatctt   3060

aaatgatgaa catgagaccg caaaaattca ctcctggaga tctccgtaga ctacaatcaa   3120

tcaaatcaat agtcagtctt gtaaggaaca aaaattagcc atgagccaaa agtatcaata   3180

aacggggagt gaagaaaccc gttttataca ataaaaccaa tgagtgtcaa gctaaagtat   3240

tgcttattca tgagcagtta aaacaaatca caaaaggaaa actaatgtta gctcgtgaaa   3300

aaaaatgctg ttgaaataaa taatgtctga tgttattctt gtatttttct gtgattgtga   3360

gaactcccgt tcctgtccca cattgtttaa cttgtataag acaatgagtc tgtttcttgt   3420

aatggctgac cagattgaag ccctgggttg tgctaaaaat aaatgcaatg attgatgcat   3480

gcaatttttt atacaaataa tttatttcta ataataaagg aatgttttgc aaatgtt      3537


<210>  2409
<211>  908
<212>  PRT
<213>  Homo sapiens

<400>  2409


Met Val Cys Glu Gly Lys Arg Ser Ala Ser Cys Pro Cys Phe Phe Leu 
1               5                   10                  15      


Leu Thr Ala Lys Phe Tyr Trp Ile Leu Thr Met Met Gln Arg Thr His 
            20                  25                  30          


Ser Gln Glu Tyr Ala His Ser Ile Arg Val Asp Gly Asp Ile Ile Leu 
        35                  40                  45              


Gly Gly Leu Phe Pro Val His Ala Lys Gly Glu Arg Gly Val Pro Cys 
    50                  55                  60                  


Gly Glu Leu Lys Lys Glu Lys Gly Ile His Arg Leu Glu Ala Met Leu 
65                  70                  75                  80  


Tyr Ala Ile Asp Gln Ile Asn Lys Asp Pro Asp Leu Leu Ser Asn Ile 
                85                  90                  95      


Thr Leu Gly Val Arg Ile Leu Asp Thr Cys Ser Arg Asp Thr Tyr Ala 
            100                 105                 110         


Leu Glu Gln Ser Leu Thr Phe Val Gln Ala Leu Ile Glu Lys Asp Ala 
        115                 120                 125             


Ser Asp Val Lys Cys Ala Asn Gly Asp Pro Pro Ile Phe Thr Lys Pro 
    130                 135                 140                 


Asp Lys Ile Ser Gly Val Ile Gly Ala Ala Ala Ser Ser Val Ser Ile 
145                 150                 155                 160 


Met Val Ala Asn Ile Leu Arg Leu Phe Lys Ile Pro Gln Ile Ser Tyr 
                165                 170                 175     


Ala Ser Thr Ala Pro Glu Leu Ser Asp Asn Thr Arg Tyr Asp Phe Phe 
            180                 185                 190         


Ser Arg Val Val Pro Pro Asp Ser Tyr Gln Ala Gln Ala Met Val Asp 
        195                 200                 205             


Ile Val Thr Ala Leu Gly Trp Asn Tyr Val Ser Thr Leu Ala Ser Glu 
    210                 215                 220                 


Gly Asn Tyr Gly Glu Ser Gly Val Glu Ala Phe Thr Gln Ile Ser Arg 
225                 230                 235                 240 


Glu Ile Gly Gly Val Cys Ile Ala Gln Ser Gln Lys Ile Pro Arg Glu 
                245                 250                 255     


Pro Arg Pro Gly Glu Phe Glu Lys Ile Ile Lys Arg Leu Leu Glu Thr 
            260                 265                 270         


Pro Asn Ala Arg Ala Val Ile Met Phe Ala Asn Glu Asp Asp Ile Arg 
        275                 280                 285             


Arg Ile Leu Glu Ala Ala Lys Lys Leu Asn Gln Ser Gly His Phe Leu 
    290                 295                 300                 


Trp Ile Gly Ser Asp Ser Trp Gly Ser Lys Ile Ala Pro Val Tyr Gln 
305                 310                 315                 320 


Gln Glu Glu Ile Ala Glu Gly Ala Val Thr Ile Leu Pro Lys Arg Ala 
                325                 330                 335     


Ser Ile Asp Gly Phe Asp Arg Tyr Phe Arg Ser Arg Thr Leu Ala Asn 
            340                 345                 350         


Asn Arg Arg Asn Val Trp Phe Ala Glu Phe Trp Glu Glu Asn Phe Gly 
        355                 360                 365             


Cys Lys Leu Gly Ser His Gly Lys Arg Asn Ser His Ile Lys Lys Cys 
    370                 375                 380                 


Thr Gly Leu Glu Arg Ile Ala Arg Asp Ser Ser Tyr Glu Gln Glu Gly 
385                 390                 395                 400 


Lys Val Gln Phe Val Ile Asp Ala Val Tyr Ser Met Ala Tyr Ala Leu 
                405                 410                 415     


His Asn Met His Lys Asp Leu Cys Pro Gly Tyr Ile Gly Leu Cys Pro 
            420                 425                 430         


Arg Met Ser Thr Ile Asp Gly Lys Glu Leu Leu Gly Tyr Ile Arg Ala 
        435                 440                 445             


Val Asn Phe Asn Gly Ser Ala Gly Thr Pro Val Thr Phe Asn Glu Asn 
    450                 455                 460                 


Gly Asp Ala Pro Gly Arg Tyr Asp Ile Phe Gln Tyr Gln Ile Thr Asn 
465                 470                 475                 480 


Lys Ser Thr Glu Tyr Lys Val Ile Gly His Trp Thr Asn Gln Leu His 
                485                 490                 495     


Leu Lys Val Glu Asp Met Gln Trp Ala His Arg Glu His Thr His Pro 
            500                 505                 510         


Ala Ser Val Cys Ser Leu Pro Cys Lys Pro Gly Glu Arg Lys Lys Thr 
        515                 520                 525             


Val Lys Gly Val Pro Cys Cys Trp His Cys Glu Arg Cys Glu Gly Tyr 
    530                 535                 540                 


Asn Tyr Gln Val Asp Glu Leu Ser Cys Glu Leu Cys Pro Leu Asp Gln 
545                 550                 555                 560 


Arg Pro Asn Met Asn Arg Thr Gly Cys Gln Leu Ile Pro Ile Ile Lys 
                565                 570                 575     


Leu Glu Trp His Ser Pro Trp Ala Val Val Pro Val Phe Val Ala Ile 
            580                 585                 590         


Leu Gly Ile Ile Ala Thr Thr Phe Val Ile Val Thr Phe Val Arg Tyr 
        595                 600                 605             


Asn Asp Thr Pro Ile Val Arg Ala Ser Gly Arg Glu Leu Ser Tyr Val 
    610                 615                 620                 


Leu Leu Thr Gly Ile Phe Leu Cys Tyr Ser Ile Thr Phe Leu Met Ile 
625                 630                 635                 640 


Ala Ala Pro Asp Thr Ile Ile Cys Ser Phe Arg Arg Val Phe Leu Gly 
                645                 650                 655     


Leu Gly Met Cys Phe Ser Tyr Ala Ala Leu Leu Thr Lys Thr Asn Arg 
            660                 665                 670         


Ile His Arg Ile Phe Glu Gln Gly Lys Lys Ser Val Thr Ala Pro Lys 
        675                 680                 685             


Phe Ile Ser Pro Ala Ser Gln Leu Val Ile Thr Phe Ser Leu Ile Ser 
    690                 695                 700                 


Val Gln Leu Leu Gly Val Phe Val Trp Phe Val Val Asp Pro Pro His 
705                 710                 715                 720 


Ile Ile Ile Asp Tyr Gly Glu Gln Arg Thr Leu Asp Pro Glu Lys Ala 
                725                 730                 735     


Arg Gly Val Leu Lys Cys Asp Ile Ser Asp Leu Ser Leu Ile Cys Ser 
            740                 745                 750         


Leu Gly Tyr Ser Ile Leu Leu Met Val Thr Cys Thr Val Tyr Ala Ile 
        755                 760                 765             


Lys Thr Arg Gly Val Pro Glu Thr Phe Asn Glu Ala Lys Pro Ile Gly 
    770                 775                 780                 


Phe Thr Met Tyr Thr Thr Cys Ile Ile Trp Leu Ala Phe Ile Pro Ile 
785                 790                 795                 800 


Phe Phe Gly Thr Ala Gln Ser Ala Glu Lys Met Tyr Ile Gln Thr Thr 
                805                 810                 815     


Thr Leu Thr Val Ser Met Ser Leu Ser Ala Ser Val Ser Leu Gly Met 
            820                 825                 830         


Leu Tyr Met Pro Lys Val Tyr Ile Ile Ile Phe His Pro Glu Gln Asn 
        835                 840                 845             


Val Gln Lys Arg Lys Arg Ser Phe Lys Ala Val Val Thr Ala Ala Thr 
    850                 855                 860                 


Met Gln Ser Lys Leu Ile Gln Lys Gly Asn Asp Arg Pro Asn Gly Glu 
865                 870                 875                 880 


Val Lys Ser Glu Leu Cys Glu Ser Leu Glu Thr Asn Ser Lys Ser Ser 
                885                 890                 895     


Val Glu Phe Pro Met Val Lys Ser Gly Ser Thr Ser 
            900                 905             

<210>  2410
<211>  3441
<212>  DNA
<213>  Homo sapiens

<400>  2410
gaggtgggcc agggggatga agagaaaggc ggggaggcaa gggcgggctg ggcgtattcc     60

acgagcgcct cggcggttgg cgaagcggac ggggtgcagc ctccccggtg cgaggaacgg    120

tctccgctga cagataccct ccttccggcc gcgccactcg ggaggcggat cccgtgggcc    180

tgaggaggct tcccccgccc ggtttgcttt ccctccctcg ctggcgctgc cgcgagtcca    240

ccgagcggcc tctgaggagc agccgcagga ggaggaggag gtcgtcgggg gcggcgggcg    300

gagaccgcgc tctcgcttcc ccggcggcgg caagggcagg acaatggagg tggcggtgga    360

gaaggcggtg gcggcggcgg cagcggcctc ggctgcggcc tccggggggc cctcggcggc    420

gccgagcggg gagaacgagg ccgagagtcg gcagggcccg gactcggagc gcggcggcga    480

ggcggcccgg ctcaacctgt tggacacttg cgccgtgtgc caccagaaca tccagagccg    540

ggcgcccaag ctgctgccct gcctgcactc tttctgccag cgctgcctgc ccgcgcccca    600

gcgctacctc atgctgcccg cgcccatgct gggctcggcc gagaccccgc cacccgtccc    660

tgcccccggc tcgccggtca gcggctcgtc gccgttcgcc acccaagttg gagtcattcg    720

ttgcccagtt tgcagccaag aatgtgcaga gagacacatc atagataact tttttgtgaa    780

ggacactact gaggttccca gcagtacagt agaaaagtca aatcaggtat gtacaagctg    840

tgaggacaac gcagaagcca atgggttttg tgtagagtgt gttgaatggc tctgcaagac    900

gtgtatcaga gctcatcaga gggtaaagtt cacaaaagac cacactgtca gacagaaaga    960

ggaagtatct ccagaggcag ttggtgtcac cagccagcga ccagtgtttt gtccttttca   1020

taaaaaggag cagctgaagc tgtactgtga gacatgtgac aaactgacat gtcgagactg   1080

tcagttgtta gaacataaag agcatagata ccaatttata gaagaagctt ttcagaatca   1140

gaaagtgatc atagatacac taatcaccaa actgatggaa aaaacaaaat acataaaatt   1200

cacaggaaat cagatccaaa acagaattat tgaagtaaat caaaatcaaa agcaggtgga   1260

acaggatatt aaagttgcta tatttacact gatggtagaa ataaataaaa aaggaaaagc   1320

tctactgcat cagttagaga gccttgcaaa ggaccatcgc atgaaactta tgcaacaaca   1380

acaggaagtg gctggactct ctaaacaatt ggagcatgtc atgcattttt ctaaatgggc   1440

agtttccagt ggcagcagta cagcattact ttatagcaaa cgactgatta cataccggtt   1500

acggcacctc cttcgtgcaa ggtgtgatgc atccccagtg accaacaaca ccatccaatt   1560

tcactgtgat cctagtttct gggctcaaaa tatcatcaac ttaggttctt tagtaatcga   1620

ggataaagag agccagccac aaatgcctaa gcagaatcct gtcgtggaac agaattcaca   1680

gccaccaagt ggtttatcat caaaccagtt atccaagttc ccaacacaga tcagcctagc   1740

tcaattacgg ctccagcata tgcagcaaca gcaaccgcct ccacgtttga taaactttca   1800

gaatcacagc cccaaaccca atggaccagt tcttcctcct catcctcaac aactgagata   1860

tccaccaaac cagaacatac cacgacaagc aataaagcca aaccccctac agatggcttt   1920

cttggctcaa caagccataa aacagtggca gatcagcagt ggacagggaa ccccatcaac   1980

taccaacagc acatcctcta ctccttccag ccccacgatt actagtgcag caggatatga   2040

tggaaaggct tttggttcac ctatgatcga tttgagctca ccagtgggag ggtcttataa   2100

tcttccctct cttccggata ttgactgttc aagtactatt atgctggaca atattgtgag   2160

gaaagatact aatatagatc atggccagcc aagaccaccc tcaaacagaa cggtccagtc   2220

accaaattca tcagtgccat ctccaggcct tgcaggacct gttactatga ctagtgtaca   2280

ccccccaata cgttcaccta gtgcctccag cgttggaagc cgaggaagct ctggctcttc   2340

cagcaaacca gcaggagctg actctacaca caaagtccca gtggtcatgc tggagccaat   2400

tcgaataaaa caagaaaaca gtggaccacc ggaaaattat gatttccctg ttgttatagt   2460

gaagcaagaa tcagatgaag aatctaggcc tcaaaatgcc aattatccaa gaagcatact   2520

cacctccctg ctcttaaata gcagtcagag ctctacttct gaggagactg tgctaagatc   2580

agatgcccct gatagtacag gagatcaacc tggacttcac caggacaatt cctcaaatgg   2640

aaagtctgaa tggttggatc cttcccagaa gtcacctctt catgttggag agacaaggaa   2700

agaggatgac cccaatgagg actggtgtgc agtttgtcaa aacggagggg aactcctctg   2760

ctgtgaaaag tgccccaaag tattccatct ttcttgtcat gtgcccacat tgacaaattt   2820

tccaagtgga gagtggattt gcactttctg ccgagactta tctaaaccag aagttgaata   2880

tgattgtgat gctcccagtc acaactcaga aaaaaagaaa actgaaggcc ttgttaagtt   2940

aacacctata gataaaagga agtgtgagcg cctactttta tttctttact gccatgaaat   3000

gagcctggct tttcaagacc ctgttcctct aactgtgcct gattattaca aaataattaa   3060

aaatccaatg gatttgtcaa ccatcaagaa aagactacaa gaagattatt ccatgtactc   3120

aaaacctgaa gattttgtag ctgattttag attgatcttt caaaactgtg ctgaattcaa   3180

tgagcctgat tcagaagtag ccaatgctgg tataaaactt gaaaattatt ttgaagaact   3240

tctaaagaac ctctatccag aaaaaaggtt tcccaaacca gaattcagga atgaatcaga   3300

agataataaa tttagtgatg attcagatga tgactttgta cagccccgga agaaacgcct   3360

caaaagcatt gaagaacgcc agttgcttaa ataatatgca gcaccactag cttgtgctgg   3420

tttttagatt tttttgtttt c                                             3441


<210>  2411
<211>  1016
<212>  PRT
<213>  Homo sapiens

<400>  2411


Met Glu Val Ala Val Glu Lys Ala Val Ala Ala Ala Ala Ala Ala Ser 
1               5                   10                  15      


Ala Ala Ala Ser Gly Gly Pro Ser Ala Ala Pro Ser Gly Glu Asn Glu 
            20                  25                  30          


Ala Glu Ser Arg Gln Gly Pro Asp Ser Glu Arg Gly Gly Glu Ala Ala 
        35                  40                  45              


Arg Leu Asn Leu Leu Asp Thr Cys Ala Val Cys His Gln Asn Ile Gln 
    50                  55                  60                  


Ser Arg Ala Pro Lys Leu Leu Pro Cys Leu His Ser Phe Cys Gln Arg 
65                  70                  75                  80  


Cys Leu Pro Ala Pro Gln Arg Tyr Leu Met Leu Pro Ala Pro Met Leu 
                85                  90                  95      


Gly Ser Ala Glu Thr Pro Pro Pro Val Pro Ala Pro Gly Ser Pro Val 
            100                 105                 110         


Ser Gly Ser Ser Pro Phe Ala Thr Gln Val Gly Val Ile Arg Cys Pro 
        115                 120                 125             


Val Cys Ser Gln Glu Cys Ala Glu Arg His Ile Ile Asp Asn Phe Phe 
    130                 135                 140                 


Val Lys Asp Thr Thr Glu Val Pro Ser Ser Thr Val Glu Lys Ser Asn 
145                 150                 155                 160 


Gln Val Cys Thr Ser Cys Glu Asp Asn Ala Glu Ala Asn Gly Phe Cys 
                165                 170                 175     


Val Glu Cys Val Glu Trp Leu Cys Lys Thr Cys Ile Arg Ala His Gln 
            180                 185                 190         


Arg Val Lys Phe Thr Lys Asp His Thr Val Arg Gln Lys Glu Glu Val 
        195                 200                 205             


Ser Pro Glu Ala Val Gly Val Thr Ser Gln Arg Pro Val Phe Cys Pro 
    210                 215                 220                 


Phe His Lys Lys Glu Gln Leu Lys Leu Tyr Cys Glu Thr Cys Asp Lys 
225                 230                 235                 240 


Leu Thr Cys Arg Asp Cys Gln Leu Leu Glu His Lys Glu His Arg Tyr 
                245                 250                 255     


Gln Phe Ile Glu Glu Ala Phe Gln Asn Gln Lys Val Ile Ile Asp Thr 
            260                 265                 270         


Leu Ile Thr Lys Leu Met Glu Lys Thr Lys Tyr Ile Lys Phe Thr Gly 
        275                 280                 285             


Asn Gln Ile Gln Asn Arg Ile Ile Glu Val Asn Gln Asn Gln Lys Gln 
    290                 295                 300                 


Val Glu Gln Asp Ile Lys Val Ala Ile Phe Thr Leu Met Val Glu Ile 
305                 310                 315                 320 


Asn Lys Lys Gly Lys Ala Leu Leu His Gln Leu Glu Ser Leu Ala Lys 
                325                 330                 335     


Asp His Arg Met Lys Leu Met Gln Gln Gln Gln Glu Val Ala Gly Leu 
            340                 345                 350         


Ser Lys Gln Leu Glu His Val Met His Phe Ser Lys Trp Ala Val Ser 
        355                 360                 365             


Ser Gly Ser Ser Thr Ala Leu Leu Tyr Ser Lys Arg Leu Ile Thr Tyr 
    370                 375                 380                 


Arg Leu Arg His Leu Leu Arg Ala Arg Cys Asp Ala Ser Pro Val Thr 
385                 390                 395                 400 


Asn Asn Thr Ile Gln Phe His Cys Asp Pro Ser Phe Trp Ala Gln Asn 
                405                 410                 415     


Ile Ile Asn Leu Gly Ser Leu Val Ile Glu Asp Lys Glu Ser Gln Pro 
            420                 425                 430         


Gln Met Pro Lys Gln Asn Pro Val Val Glu Gln Asn Ser Gln Pro Pro 
        435                 440                 445             


Ser Gly Leu Ser Ser Asn Gln Leu Ser Lys Phe Pro Thr Gln Ile Ser 
    450                 455                 460                 


Leu Ala Gln Leu Arg Leu Gln His Met Gln Gln Gln Gln Pro Pro Pro 
465                 470                 475                 480 


Arg Leu Ile Asn Phe Gln Asn His Ser Pro Lys Pro Asn Gly Pro Val 
                485                 490                 495     


Leu Pro Pro His Pro Gln Gln Leu Arg Tyr Pro Pro Asn Gln Asn Ile 
            500                 505                 510         


Pro Arg Gln Ala Ile Lys Pro Asn Pro Leu Gln Met Ala Phe Leu Ala 
        515                 520                 525             


Gln Gln Ala Ile Lys Gln Trp Gln Ile Ser Ser Gly Gln Gly Thr Pro 
    530                 535                 540                 


Ser Thr Thr Asn Ser Thr Ser Ser Thr Pro Ser Ser Pro Thr Ile Thr 
545                 550                 555                 560 


Ser Ala Ala Gly Tyr Asp Gly Lys Ala Phe Gly Ser Pro Met Ile Asp 
                565                 570                 575     


Leu Ser Ser Pro Val Gly Gly Ser Tyr Asn Leu Pro Ser Leu Pro Asp 
            580                 585                 590         


Ile Asp Cys Ser Ser Thr Ile Met Leu Asp Asn Ile Val Arg Lys Asp 
        595                 600                 605             


Thr Asn Ile Asp His Gly Gln Pro Arg Pro Pro Ser Asn Arg Thr Val 
    610                 615                 620                 


Gln Ser Pro Asn Ser Ser Val Pro Ser Pro Gly Leu Ala Gly Pro Val 
625                 630                 635                 640 


Thr Met Thr Ser Val His Pro Pro Ile Arg Ser Pro Ser Ala Ser Ser 
                645                 650                 655     


Val Gly Ser Arg Gly Ser Ser Gly Ser Ser Ser Lys Pro Ala Gly Ala 
            660                 665                 670         


Asp Ser Thr His Lys Val Pro Val Val Met Leu Glu Pro Ile Arg Ile 
        675                 680                 685             


Lys Gln Glu Asn Ser Gly Pro Pro Glu Asn Tyr Asp Phe Pro Val Val 
    690                 695                 700                 


Ile Val Lys Gln Glu Ser Asp Glu Glu Ser Arg Pro Gln Asn Ala Asn 
705                 710                 715                 720 


Tyr Pro Arg Ser Ile Leu Thr Ser Leu Leu Leu Asn Ser Ser Gln Ser 
                725                 730                 735     


Ser Thr Ser Glu Glu Thr Val Leu Arg Ser Asp Ala Pro Asp Ser Thr 
            740                 745                 750         


Gly Asp Gln Pro Gly Leu His Gln Asp Asn Ser Ser Asn Gly Lys Ser 
        755                 760                 765             


Glu Trp Leu Asp Pro Ser Gln Lys Ser Pro Leu His Val Gly Glu Thr 
    770                 775                 780                 


Arg Lys Glu Asp Asp Pro Asn Glu Asp Trp Cys Ala Val Cys Gln Asn 
785                 790                 795                 800 


Gly Gly Glu Leu Leu Cys Cys Glu Lys Cys Pro Lys Val Phe His Leu 
                805                 810                 815     


Ser Cys His Val Pro Thr Leu Thr Asn Phe Pro Ser Gly Glu Trp Ile 
            820                 825                 830         


Cys Thr Phe Cys Arg Asp Leu Ser Lys Pro Glu Val Glu Tyr Asp Cys 
        835                 840                 845             


Asp Ala Pro Ser His Asn Ser Glu Lys Lys Lys Thr Glu Gly Leu Val 
    850                 855                 860                 


Lys Leu Thr Pro Ile Asp Lys Arg Lys Cys Glu Arg Leu Leu Leu Phe 
865                 870                 875                 880 


Leu Tyr Cys His Glu Met Ser Leu Ala Phe Gln Asp Pro Val Pro Leu 
                885                 890                 895     


Thr Val Pro Asp Tyr Tyr Lys Ile Ile Lys Asn Pro Met Asp Leu Ser 
            900                 905                 910         


Thr Ile Lys Lys Arg Leu Gln Glu Asp Tyr Ser Met Tyr Ser Lys Pro 
        915                 920                 925             


Glu Asp Phe Val Ala Asp Phe Arg Leu Ile Phe Gln Asn Cys Ala Glu 
    930                 935                 940                 


Phe Asn Glu Pro Asp Ser Glu Val Ala Asn Ala Gly Ile Lys Leu Glu 
945                 950                 955                 960 


Asn Tyr Phe Glu Glu Leu Leu Lys Asn Leu Tyr Pro Glu Lys Arg Phe 
                965                 970                 975     


Pro Lys Pro Glu Phe Arg Asn Glu Ser Glu Asp Asn Lys Phe Ser Asp 
            980                 985                 990         


Asp Ser Asp Asp Asp Phe Val Gln  Pro Arg Lys Lys Arg  Leu Lys Ser 
        995                 1000                 1005             


Ile Glu  Glu Arg Gln Leu Leu  Lys 
    1010                 1015     

<210>  2412
<211>  4130
<212>  DNA
<213>  Homo sapiens

<400>  2412
gaggtgggcc agggggatga agagaaaggc ggggaggcaa gggcgggctg ggcgtattcc     60

acgagcgcct cggcggttgg cgaagcggac ggggtgcagc ctccccggtg cgaggaacgg    120

tctccgctga cagataccct ccttccggcc gcgccactcg ggaggcggat cccgtgggcc    180

tgaggaggct tcccccgccc ggtttgcttt ccctccctcg ctggcgctgc cgcgagtcca    240

ccgagcggcc tctgaggagc agccgcagga ggaggaggag gtcgtcgggg gcggcgggcg    300

gagaccgcgc tctcgcttcc ccggcggcgg caagggcagg acaatggagg tggcggtgga    360

gaaggcggtg gcggcggcgg cagcggcctc ggctgcggcc tccggggggc cctcggcggc    420

gccgagcggg gagaacgagg ccgagagtcg gcagggcccg gactcggagc gcggcggcga    480

ggcggcccgg ctcaacctgt tggacacttg cgccgtgtgc caccagaaca tccagagccg    540

ggcgcccaag ctgctgccct gcctgcactc tttctgccag cgctgcctgc ccgcgcccca    600

gcgctacctc atgctgcccg cgcccatgct gggctcggcc gagaccccgc cacccgtccc    660

tgcccccggc tcgccggtca gcggctcgtc gccgttcgcc acccaagttg gagtcattcg    720

ttgcccagtt tgcagccaag aatgtgcaga gagacacatc atagataact tttttgtgaa    780

ggacactact gaggttccca gcagtacagt agaaaagtca aatcaggtat gtacaagctg    840

tgaggacaac gcagaagcca atgggttttg tgtagagtgt gttgaatggc tctgcaagac    900

gtgtatcaga gctcatcaga gggtaaagtt cacaaaagac cacactgtca gacagaaaga    960

ggaagtatct ccagaggcag ttggtgtcac cagccagcga ccagtgtttt gtccttttca   1020

taaaaaggag cagctgaagc tgtactgtga gacatgtgac aaactgacat gtcgagactg   1080

tcagttgtta gaacataaag agcatagata ccaatttata gaagaagctt ttcagaatca   1140

gaaagtgatc atagatacac taatcaccaa actgatggaa aaaacaaaat acataaaatt   1200

cacaggaaat cagatccaaa acagaattat tgaagtaaat caaaatcaaa agcaggtgga   1260

acaggatatt aaagttgcta tatttacact gatggtagaa ataaataaaa aaggaaaagc   1320

tctactgcat cagttagaga gccttgcaaa ggaccatcgc atgaaactta tgcaacaaca   1380

acaggaagtg gctggactct ctaaacaatt ggagcatgtc atgcattttt ctaaatgggc   1440

agtttccagt ggcagcagta cagcattact ttatagcaaa cgactgatta cataccggtt   1500

acggcacctc cttcgtgcaa ggtgtgatgc atccccagtg accaacaaca ccatccaatt   1560

tcactgtgat cctagtttct gggctcaaaa tatcatcaac ttaggttctt tagtaatcga   1620

ggataaagag agccagccac aaatgcctaa gcagaatcct gtcgtggaac agaattcaca   1680

gccaccaagt ggtttatcat caaaccagtt atccaagttc ccaacacaga tcagcctagc   1740

tcaattacgg ctccagcata tgcagcaaca ggtaatggct cagaggcaac aggtgcaacg   1800

gaggccagca cctgtgggtt taccaaaccc tagaatgcag gggcccatcc agcaaccttc   1860

catctctcat cagcaaccgc ctccacgttt gataaacttt cagaatcaca gccccaaacc   1920

caatggacca gttcttcctc ctcatcctca acaactgaga tatccaccaa accagaacat   1980

accacgacaa gcaataaagc caaaccccct acagatggct ttcttggctc aacaagccat   2040

aaaacagtgg cagatcagca gtggacaggg aaccccatca actaccaaca gcacatcctc   2100

tactccttcc agccccacga ttactagtgc agcaggatat gatggaaagg cttttggttc   2160

acctatgatc gatttgagct caccagtggg agggtcttat aatcttccct ctcttccgga   2220

tattgactgt tcaagtacta ttatgctgga caatattgtg aggaaagata ctaatataga   2280

tcatggccag ccaagaccac cctcaaacag aacggtccag tcaccaaatt catcagtgcc   2340

atctccaggc cttgcaggac ctgttactat gactagtgta caccccccaa tacgttcacc   2400

tagtgcctcc agcgttggaa gccgaggaag ctctggctct tccagcaaac cagcaggagc   2460

tgactctaca cacaaagtcc cagtggtcat gctggagcca attcgaataa aacaagaaaa   2520

cagtggacca ccggaaaatt atgatttccc tgttgttata gtgaagcaag aatcagatga   2580

agaatctagg cctcaaaatg ccaattatcc aagaagcata ctcacctccc tgctcttaaa   2640

tagcagtcag agctctactt ctgaggagac tgtgctaaga tcagatgccc ctgatagtac   2700

aggagatcaa cctggacttc accaggacaa ttcctcaaat ggaaagtctg aatggttgga   2760

tccttcccag aagtcacctc ttcatgttgg agagacaagg aaagaggatg accccaatga   2820

ggactggtgt gcagtttgtc aaaacggagg ggaactcctc tgctgtgaaa agtgccccaa   2880

agtattccat ctttcttgtc atgtgcccac attgacaaat tttccaagtg gagagtggat   2940

ttgcactttc tgccgagact tatctaaacc agaagttgaa tatgattgtg atgctcccag   3000

tcacaactca gaaaaaaaga aaactgaagg ccttgttaag ttaacaccta tagataaaag   3060

gaagtgtgag cgcctacttt tatttcttta ctgccatgaa atgagcctgg cttttcaaga   3120

ccctgttcct ctaactgtgc ctgattatta caaaataatt aaaaatccaa tggatttgtc   3180

aaccatcaag aaaagactac aagaagatta ttccatgtac tcaaaacctg aagattttgt   3240

agctgatttt agattgatct ttcaaaactg tgctgaattc aatgagcctg attcagaagt   3300

agccaatgct ggtataaaac ttgaaaatta ttttgaagaa cttctaaaga acctctatcc   3360

agaaaaaagg tttcccaaac cagaattcag gaatgaatca gaagataata aatttagtga   3420

tgattcagat gatgactttg tacagccccg gaagaaacgc ctcaaaagca ttgaagaacg   3480

ccagttgctt aaataatatg cagcaccact agcttgtgct ggtttttaga tttttttgtt   3540

ttcaaaaaaa catttgtcag taatttaaca tcactacaaa aagaagagtt tgtgactatt   3600

ctcatctctg ttttggacgt ttactagact ttgatttcct taatagccca tttctgttaa   3660

cctcttatca ctaagaaaga aaggaaagaa ggagatgaat agaagaaaga aaatggaaag   3720

aaggaaaaaa ggaggataga aaaaggatgg aagaaagaag cattgaaaac aaagacattc   3780

ttcccacttc ttggattttt aaaccacagt ctggagtgat agctactgta gaaaggaaat   3840

agactttgta tgaactcttt aagttgaaaa gtaaaaaata tatgtggttt ggatgtgtgc   3900

tttaattcag ctttagaaat taataccact acccgtgaat tatatggcct gacaatatga   3960

attaggtgta ctgtactgaa gaacagtact ccacaaacat gggtggtaac aagagttcca   4020

tcccaggagg ccaaacggtg caacagaagg gtaggttaga tgctattaag aaggcactta   4080

atagtacatc atgtaagatg gcaactgtat taaagaaaaa tccggaaaac              4130


<210>  2413
<211>  1050
<212>  PRT
<213>  Homo sapiens

<400>  2413


Met Glu Val Ala Val Glu Lys Ala Val Ala Ala Ala Ala Ala Ala Ser 
1               5                   10                  15      


Ala Ala Ala Ser Gly Gly Pro Ser Ala Ala Pro Ser Gly Glu Asn Glu 
            20                  25                  30          


Ala Glu Ser Arg Gln Gly Pro Asp Ser Glu Arg Gly Gly Glu Ala Ala 
        35                  40                  45              


Arg Leu Asn Leu Leu Asp Thr Cys Ala Val Cys His Gln Asn Ile Gln 
    50                  55                  60                  


Ser Arg Ala Pro Lys Leu Leu Pro Cys Leu His Ser Phe Cys Gln Arg 
65                  70                  75                  80  


Cys Leu Pro Ala Pro Gln Arg Tyr Leu Met Leu Pro Ala Pro Met Leu 
                85                  90                  95      


Gly Ser Ala Glu Thr Pro Pro Pro Val Pro Ala Pro Gly Ser Pro Val 
            100                 105                 110         


Ser Gly Ser Ser Pro Phe Ala Thr Gln Val Gly Val Ile Arg Cys Pro 
        115                 120                 125             


Val Cys Ser Gln Glu Cys Ala Glu Arg His Ile Ile Asp Asn Phe Phe 
    130                 135                 140                 


Val Lys Asp Thr Thr Glu Val Pro Ser Ser Thr Val Glu Lys Ser Asn 
145                 150                 155                 160 


Gln Val Cys Thr Ser Cys Glu Asp Asn Ala Glu Ala Asn Gly Phe Cys 
                165                 170                 175     


Val Glu Cys Val Glu Trp Leu Cys Lys Thr Cys Ile Arg Ala His Gln 
            180                 185                 190         


Arg Val Lys Phe Thr Lys Asp His Thr Val Arg Gln Lys Glu Glu Val 
        195                 200                 205             


Ser Pro Glu Ala Val Gly Val Thr Ser Gln Arg Pro Val Phe Cys Pro 
    210                 215                 220                 


Phe His Lys Lys Glu Gln Leu Lys Leu Tyr Cys Glu Thr Cys Asp Lys 
225                 230                 235                 240 


Leu Thr Cys Arg Asp Cys Gln Leu Leu Glu His Lys Glu His Arg Tyr 
                245                 250                 255     


Gln Phe Ile Glu Glu Ala Phe Gln Asn Gln Lys Val Ile Ile Asp Thr 
            260                 265                 270         


Leu Ile Thr Lys Leu Met Glu Lys Thr Lys Tyr Ile Lys Phe Thr Gly 
        275                 280                 285             


Asn Gln Ile Gln Asn Arg Ile Ile Glu Val Asn Gln Asn Gln Lys Gln 
    290                 295                 300                 


Val Glu Gln Asp Ile Lys Val Ala Ile Phe Thr Leu Met Val Glu Ile 
305                 310                 315                 320 


Asn Lys Lys Gly Lys Ala Leu Leu His Gln Leu Glu Ser Leu Ala Lys 
                325                 330                 335     


Asp His Arg Met Lys Leu Met Gln Gln Gln Gln Glu Val Ala Gly Leu 
            340                 345                 350         


Ser Lys Gln Leu Glu His Val Met His Phe Ser Lys Trp Ala Val Ser 
        355                 360                 365             


Ser Gly Ser Ser Thr Ala Leu Leu Tyr Ser Lys Arg Leu Ile Thr Tyr 
    370                 375                 380                 


Arg Leu Arg His Leu Leu Arg Ala Arg Cys Asp Ala Ser Pro Val Thr 
385                 390                 395                 400 


Asn Asn Thr Ile Gln Phe His Cys Asp Pro Ser Phe Trp Ala Gln Asn 
                405                 410                 415     


Ile Ile Asn Leu Gly Ser Leu Val Ile Glu Asp Lys Glu Ser Gln Pro 
            420                 425                 430         


Gln Met Pro Lys Gln Asn Pro Val Val Glu Gln Asn Ser Gln Pro Pro 
        435                 440                 445             


Ser Gly Leu Ser Ser Asn Gln Leu Ser Lys Phe Pro Thr Gln Ile Ser 
    450                 455                 460                 


Leu Ala Gln Leu Arg Leu Gln His Met Gln Gln Gln Val Met Ala Gln 
465                 470                 475                 480 


Arg Gln Gln Val Gln Arg Arg Pro Ala Pro Val Gly Leu Pro Asn Pro 
                485                 490                 495     


Arg Met Gln Gly Pro Ile Gln Gln Pro Ser Ile Ser His Gln Gln Pro 
            500                 505                 510         


Pro Pro Arg Leu Ile Asn Phe Gln Asn His Ser Pro Lys Pro Asn Gly 
        515                 520                 525             


Pro Val Leu Pro Pro His Pro Gln Gln Leu Arg Tyr Pro Pro Asn Gln 
    530                 535                 540                 


Asn Ile Pro Arg Gln Ala Ile Lys Pro Asn Pro Leu Gln Met Ala Phe 
545                 550                 555                 560 


Leu Ala Gln Gln Ala Ile Lys Gln Trp Gln Ile Ser Ser Gly Gln Gly 
                565                 570                 575     


Thr Pro Ser Thr Thr Asn Ser Thr Ser Ser Thr Pro Ser Ser Pro Thr 
            580                 585                 590         


Ile Thr Ser Ala Ala Gly Tyr Asp Gly Lys Ala Phe Gly Ser Pro Met 
        595                 600                 605             


Ile Asp Leu Ser Ser Pro Val Gly Gly Ser Tyr Asn Leu Pro Ser Leu 
    610                 615                 620                 


Pro Asp Ile Asp Cys Ser Ser Thr Ile Met Leu Asp Asn Ile Val Arg 
625                 630                 635                 640 


Lys Asp Thr Asn Ile Asp His Gly Gln Pro Arg Pro Pro Ser Asn Arg 
                645                 650                 655     


Thr Val Gln Ser Pro Asn Ser Ser Val Pro Ser Pro Gly Leu Ala Gly 
            660                 665                 670         


Pro Val Thr Met Thr Ser Val His Pro Pro Ile Arg Ser Pro Ser Ala 
        675                 680                 685             


Ser Ser Val Gly Ser Arg Gly Ser Ser Gly Ser Ser Ser Lys Pro Ala 
    690                 695                 700                 


Gly Ala Asp Ser Thr His Lys Val Pro Val Val Met Leu Glu Pro Ile 
705                 710                 715                 720 


Arg Ile Lys Gln Glu Asn Ser Gly Pro Pro Glu Asn Tyr Asp Phe Pro 
                725                 730                 735     


Val Val Ile Val Lys Gln Glu Ser Asp Glu Glu Ser Arg Pro Gln Asn 
            740                 745                 750         


Ala Asn Tyr Pro Arg Ser Ile Leu Thr Ser Leu Leu Leu Asn Ser Ser 
        755                 760                 765             


Gln Ser Ser Thr Ser Glu Glu Thr Val Leu Arg Ser Asp Ala Pro Asp 
    770                 775                 780                 


Ser Thr Gly Asp Gln Pro Gly Leu His Gln Asp Asn Ser Ser Asn Gly 
785                 790                 795                 800 


Lys Ser Glu Trp Leu Asp Pro Ser Gln Lys Ser Pro Leu His Val Gly 
                805                 810                 815     


Glu Thr Arg Lys Glu Asp Asp Pro Asn Glu Asp Trp Cys Ala Val Cys 
            820                 825                 830         


Gln Asn Gly Gly Glu Leu Leu Cys Cys Glu Lys Cys Pro Lys Val Phe 
        835                 840                 845             


His Leu Ser Cys His Val Pro Thr Leu Thr Asn Phe Pro Ser Gly Glu 
    850                 855                 860                 


Trp Ile Cys Thr Phe Cys Arg Asp Leu Ser Lys Pro Glu Val Glu Tyr 
865                 870                 875                 880 


Asp Cys Asp Ala Pro Ser His Asn Ser Glu Lys Lys Lys Thr Glu Gly 
                885                 890                 895     


Leu Val Lys Leu Thr Pro Ile Asp Lys Arg Lys Cys Glu Arg Leu Leu 
            900                 905                 910         


Leu Phe Leu Tyr Cys His Glu Met Ser Leu Ala Phe Gln Asp Pro Val 
        915                 920                 925             


Pro Leu Thr Val Pro Asp Tyr Tyr Lys Ile Ile Lys Asn Pro Met Asp 
    930                 935                 940                 


Leu Ser Thr Ile Lys Lys Arg Leu Gln Glu Asp Tyr Ser Met Tyr Ser 
945                 950                 955                 960 


Lys Pro Glu Asp Phe Val Ala Asp Phe Arg Leu Ile Phe Gln Asn Cys 
                965                 970                 975     


Ala Glu Phe Asn Glu Pro Asp Ser Glu Val Ala Asn Ala Gly Ile Lys 
            980                 985                 990         


Leu Glu Asn Tyr Phe Glu Glu Leu  Leu Lys Asn Leu Tyr  Pro Glu Lys 
        995                 1000                 1005             


Arg Phe  Pro Lys Pro Glu Phe  Arg Asn Glu Ser Glu  Asp Asn Lys 
    1010                 1015                 1020             


Phe Ser  Asp Asp Ser Asp Asp  Asp Phe Val Gln Pro  Arg Lys Lys 
    1025                 1030                 1035             


Arg Leu  Lys Ser Ile Glu Glu  Arg Gln Leu Leu Lys  
    1040                 1045                 1050 

<210>  2414
<211>  4028
<212>  DNA
<213>  Homo sapiens

<400>  2414
gaggtgggcc agggggatga agagaaaggc ggggaggcaa gggcgggctg ggcgtattcc     60

acgagcgcct cggcggttgg cgaagcggac ggggtgcagc ctccccggtg cgaggaacgg    120

tctccgctga cagataccct ccttccggcc gcgccactcg ggaggcggat cccgtgggcc    180

tgaggaggct tcccccgccc ggtttgcttt ccctccctcg ctggcgctgc cgcgagtcca    240

ccgagcggcc tctgaggagc agccgcagga ggaggaggag gtcgtcgggg gcggcgggcg    300

gagaccgcgc tctcgcttcc ccggcggcgg caagggcagg acaatggagg tggcggtgga    360

gaaggcggtg gcggcggcgg cagcggcctc ggctgcggcc tccggggggc cctcggcggc    420

gccgagcggg gagaacgagg ccgagagtcg gcagggcccg gactcggagc gcggcggcga    480

ggcggcccgg ctcaacctgt tggacacttg cgccgtgtgc caccagaaca tccagagccg    540

ggcgcccaag ctgctgccct gcctgcactc tttctgccag cgctgcctgc ccgcgcccca    600

gcgctacctc atgctgcccg cgcccatgct gggctcggcc gagaccccgc cacccgtccc    660

tgcccccggc tcgccggtca gcggctcgtc gccgttcgcc acccaagttg gagtcattcg    720

ttgcccagtt tgcagccaag aatgtgcaga gagacacatc atagataact tttttgtgaa    780

ggacactact gaggttccca gcagtacagt agaaaagtca aatcaggtat gtacaagctg    840

tgaggacaac gcagaagcca atgggttttg tgtagagtgt gttgaatggc tctgcaagac    900

gtgtatcaga gctcatcaga gggtaaagtt cacaaaagac cacactgtca gacagaaaga    960

ggaagtatct ccagaggcag ttggtgtcac cagccagcga ccagtgtttt gtccttttca   1020

taaaaaggag cagctgaagc tgtactgtga gacatgtgac aaactgacat gtcgagactg   1080

tcagttgtta gaacataaag agcatagata ccaatttata gaagaagctt ttcagaatca   1140

gaaagtgatc atagatacac taatcaccaa actgatggaa aaaacaaaat acataaaatt   1200

cacaggaaat cagatccaaa acagaattat tgaagtaaat caaaatcaaa agcaggtgga   1260

acaggatatt aaagttgcta tatttacact gatggtagaa ataaataaaa aaggaaaagc   1320

tctactgcat cagttagaga gccttgcaaa ggaccatcgc atgaaactta tgcaacaaca   1380

acaggaagtg gctggactct ctaaacaatt ggagcatgtc atgcattttt ctaaatgggc   1440

agtttccagt ggcagcagta cagcattact ttatagcaaa cgactgatta cataccggtt   1500

acggcacctc cttcgtgcaa ggtgtgatgc atccccagtg accaacaaca ccatccaatt   1560

tcactgtgat cctagtttct gggctcaaaa tatcatcaac ttaggttctt tagtaatcga   1620

ggataaagag agccagccac aaatgcctaa gcagaatcct gtcgtggaac agaattcaca   1680

gccaccaagt ggtttatcat caaaccagtt atccaagttc ccaacacaga tcagcctagc   1740

tcaattacgg ctccagcata tgcagcaaca gcaaccgcct ccacgtttga taaactttca   1800

gaatcacagc cccaaaccca atggaccagt tcttcctcct catcctcaac aactgagata   1860

tccaccaaac cagaacatac cacgacaagc aataaagcca aaccccctac agatggcttt   1920

cttggctcaa caagccataa aacagtggca gatcagcagt ggacagggaa ccccatcaac   1980

taccaacagc acatcctcta ctccttccag ccccacgatt actagtgcag caggatatga   2040

tggaaaggct tttggttcac ctatgatcga tttgagctca ccagtgggag ggtcttataa   2100

tcttccctct cttccggata ttgactgttc aagtactatt atgctggaca atattgtgag   2160

gaaagatact aatatagatc atggccagcc aagaccaccc tcaaacagaa cggtccagtc   2220

accaaattca tcagtgccat ctccaggcct tgcaggacct gttactatga ctagtgtaca   2280

ccccccaata cgttcaccta gtgcctccag cgttggaagc cgaggaagct ctggctcttc   2340

cagcaaacca gcaggagctg actctacaca caaagtccca gtggtcatgc tggagccaat   2400

tcgaataaaa caagaaaaca gtggaccacc ggaaaattat gatttccctg ttgttatagt   2460

gaagcaagaa tcagatgaag aatctaggcc tcaaaatgcc aattatccaa gaagcatact   2520

cacctccctg ctcttaaata gcagtcagag ctctacttct gaggagactg tgctaagatc   2580

agatgcccct gatagtacag gagatcaacc tggacttcac caggacaatt cctcaaatgg   2640

aaagtctgaa tggttggatc cttcccagaa gtcacctctt catgttggag agacaaggaa   2700

agaggatgac cccaatgagg actggtgtgc agtttgtcaa aacggagggg aactcctctg   2760

ctgtgaaaag tgccccaaag tattccatct ttcttgtcat gtgcccacat tgacaaattt   2820

tccaagtgga gagtggattt gcactttctg ccgagactta tctaaaccag aagttgaata   2880

tgattgtgat gctcccagtc acaactcaga aaaaaagaaa actgaaggcc ttgttaagtt   2940

aacacctata gataaaagga agtgtgagcg cctactttta tttctttact gccatgaaat   3000

gagcctggct tttcaagacc ctgttcctct aactgtgcct gattattaca aaataattaa   3060

aaatccaatg gatttgtcaa ccatcaagaa aagactacaa gaagattatt ccatgtactc   3120

aaaacctgaa gattttgtag ctgattttag attgatcttt caaaactgtg ctgaattcaa   3180

tgagcctgat tcagaagtag ccaatgctgg tataaaactt gaaaattatt ttgaagaact   3240

tctaaagaac ctctatccag aaaaaaggtt tcccaaacca gaattcagga atgaatcaga   3300

agataataaa tttagtgatg attcagatga tgactttgta cagccccgga agaaacgcct   3360

caaaagcatt gaagaacgcc agttgcttaa ataatatgca gcaccactag cttgtgctgg   3420

tttttagatt tttttgtttt caaaaaaaca tttgtcagta atttaacatc actacaaaaa   3480

gaagagtttg tgactattct catctctgtt ttggacgttt actagacttt gatttcctta   3540

atagcccatt tctgttaacc tcttatcact aagaaagaaa ggaaagaagg agatgaatag   3600

aagaaagaaa atggaaagaa ggaaaaaagg aggatagaaa aaggatggaa gaaagaagca   3660

ttgaaaacaa agacattctt cccacttctt ggatttttaa accacagtct ggagtgatag   3720

ctactgtaga aaggaaatag actttgtatg aactctttaa gttgaaaagt aaaaaatata   3780

tgtggtttgg atgtgtgctt taattcagct ttagaaatta ataccactac ccgtgaatta   3840

tatggcctga caatatgaat taggtgtact gtactgaaga acagtactcc acaaacatgg   3900

gtggtaacaa gagttccatc ccaggaggcc aaacggtgca acagaagggt aggttagatg   3960

ctattaagaa ggcacttaat agtacatcat gtaagatggc aactgtatta aagaaaaatc   4020

cggaaaac                                                            4028


<210>  2415
<211>  1016
<212>  PRT
<213>  Homo sapiens

<400>  2415


Met Glu Val Ala Val Glu Lys Ala Val Ala Ala Ala Ala Ala Ala Ser 
1               5                   10                  15      


Ala Ala Ala Ser Gly Gly Pro Ser Ala Ala Pro Ser Gly Glu Asn Glu 
            20                  25                  30          


Ala Glu Ser Arg Gln Gly Pro Asp Ser Glu Arg Gly Gly Glu Ala Ala 
        35                  40                  45              


Arg Leu Asn Leu Leu Asp Thr Cys Ala Val Cys His Gln Asn Ile Gln 
    50                  55                  60                  


Ser Arg Ala Pro Lys Leu Leu Pro Cys Leu His Ser Phe Cys Gln Arg 
65                  70                  75                  80  


Cys Leu Pro Ala Pro Gln Arg Tyr Leu Met Leu Pro Ala Pro Met Leu 
                85                  90                  95      


Gly Ser Ala Glu Thr Pro Pro Pro Val Pro Ala Pro Gly Ser Pro Val 
            100                 105                 110         


Ser Gly Ser Ser Pro Phe Ala Thr Gln Val Gly Val Ile Arg Cys Pro 
        115                 120                 125             


Val Cys Ser Gln Glu Cys Ala Glu Arg His Ile Ile Asp Asn Phe Phe 
    130                 135                 140                 


Val Lys Asp Thr Thr Glu Val Pro Ser Ser Thr Val Glu Lys Ser Asn 
145                 150                 155                 160 


Gln Val Cys Thr Ser Cys Glu Asp Asn Ala Glu Ala Asn Gly Phe Cys 
                165                 170                 175     


Val Glu Cys Val Glu Trp Leu Cys Lys Thr Cys Ile Arg Ala His Gln 
            180                 185                 190         


Arg Val Lys Phe Thr Lys Asp His Thr Val Arg Gln Lys Glu Glu Val 
        195                 200                 205             


Ser Pro Glu Ala Val Gly Val Thr Ser Gln Arg Pro Val Phe Cys Pro 
    210                 215                 220                 


Phe His Lys Lys Glu Gln Leu Lys Leu Tyr Cys Glu Thr Cys Asp Lys 
225                 230                 235                 240 


Leu Thr Cys Arg Asp Cys Gln Leu Leu Glu His Lys Glu His Arg Tyr 
                245                 250                 255     


Gln Phe Ile Glu Glu Ala Phe Gln Asn Gln Lys Val Ile Ile Asp Thr 
            260                 265                 270         


Leu Ile Thr Lys Leu Met Glu Lys Thr Lys Tyr Ile Lys Phe Thr Gly 
        275                 280                 285             


Asn Gln Ile Gln Asn Arg Ile Ile Glu Val Asn Gln Asn Gln Lys Gln 
    290                 295                 300                 


Val Glu Gln Asp Ile Lys Val Ala Ile Phe Thr Leu Met Val Glu Ile 
305                 310                 315                 320 


Asn Lys Lys Gly Lys Ala Leu Leu His Gln Leu Glu Ser Leu Ala Lys 
                325                 330                 335     


Asp His Arg Met Lys Leu Met Gln Gln Gln Gln Glu Val Ala Gly Leu 
            340                 345                 350         


Ser Lys Gln Leu Glu His Val Met His Phe Ser Lys Trp Ala Val Ser 
        355                 360                 365             


Ser Gly Ser Ser Thr Ala Leu Leu Tyr Ser Lys Arg Leu Ile Thr Tyr 
    370                 375                 380                 


Arg Leu Arg His Leu Leu Arg Ala Arg Cys Asp Ala Ser Pro Val Thr 
385                 390                 395                 400 


Asn Asn Thr Ile Gln Phe His Cys Asp Pro Ser Phe Trp Ala Gln Asn 
                405                 410                 415     


Ile Ile Asn Leu Gly Ser Leu Val Ile Glu Asp Lys Glu Ser Gln Pro 
            420                 425                 430         


Gln Met Pro Lys Gln Asn Pro Val Val Glu Gln Asn Ser Gln Pro Pro 
        435                 440                 445             


Ser Gly Leu Ser Ser Asn Gln Leu Ser Lys Phe Pro Thr Gln Ile Ser 
    450                 455                 460                 


Leu Ala Gln Leu Arg Leu Gln His Met Gln Gln Gln Gln Pro Pro Pro 
465                 470                 475                 480 


Arg Leu Ile Asn Phe Gln Asn His Ser Pro Lys Pro Asn Gly Pro Val 
                485                 490                 495     


Leu Pro Pro His Pro Gln Gln Leu Arg Tyr Pro Pro Asn Gln Asn Ile 
            500                 505                 510         


Pro Arg Gln Ala Ile Lys Pro Asn Pro Leu Gln Met Ala Phe Leu Ala 
        515                 520                 525             


Gln Gln Ala Ile Lys Gln Trp Gln Ile Ser Ser Gly Gln Gly Thr Pro 
    530                 535                 540                 


Ser Thr Thr Asn Ser Thr Ser Ser Thr Pro Ser Ser Pro Thr Ile Thr 
545                 550                 555                 560 


Ser Ala Ala Gly Tyr Asp Gly Lys Ala Phe Gly Ser Pro Met Ile Asp 
                565                 570                 575     


Leu Ser Ser Pro Val Gly Gly Ser Tyr Asn Leu Pro Ser Leu Pro Asp 
            580                 585                 590         


Ile Asp Cys Ser Ser Thr Ile Met Leu Asp Asn Ile Val Arg Lys Asp 
        595                 600                 605             


Thr Asn Ile Asp His Gly Gln Pro Arg Pro Pro Ser Asn Arg Thr Val 
    610                 615                 620                 


Gln Ser Pro Asn Ser Ser Val Pro Ser Pro Gly Leu Ala Gly Pro Val 
625                 630                 635                 640 


Thr Met Thr Ser Val His Pro Pro Ile Arg Ser Pro Ser Ala Ser Ser 
                645                 650                 655     


Val Gly Ser Arg Gly Ser Ser Gly Ser Ser Ser Lys Pro Ala Gly Ala 
            660                 665                 670         


Asp Ser Thr His Lys Val Pro Val Val Met Leu Glu Pro Ile Arg Ile 
        675                 680                 685             


Lys Gln Glu Asn Ser Gly Pro Pro Glu Asn Tyr Asp Phe Pro Val Val 
    690                 695                 700                 


Ile Val Lys Gln Glu Ser Asp Glu Glu Ser Arg Pro Gln Asn Ala Asn 
705                 710                 715                 720 


Tyr Pro Arg Ser Ile Leu Thr Ser Leu Leu Leu Asn Ser Ser Gln Ser 
                725                 730                 735     


Ser Thr Ser Glu Glu Thr Val Leu Arg Ser Asp Ala Pro Asp Ser Thr 
            740                 745                 750         


Gly Asp Gln Pro Gly Leu His Gln Asp Asn Ser Ser Asn Gly Lys Ser 
        755                 760                 765             


Glu Trp Leu Asp Pro Ser Gln Lys Ser Pro Leu His Val Gly Glu Thr 
    770                 775                 780                 


Arg Lys Glu Asp Asp Pro Asn Glu Asp Trp Cys Ala Val Cys Gln Asn 
785                 790                 795                 800 


Gly Gly Glu Leu Leu Cys Cys Glu Lys Cys Pro Lys Val Phe His Leu 
                805                 810                 815     


Ser Cys His Val Pro Thr Leu Thr Asn Phe Pro Ser Gly Glu Trp Ile 
            820                 825                 830         


Cys Thr Phe Cys Arg Asp Leu Ser Lys Pro Glu Val Glu Tyr Asp Cys 
        835                 840                 845             


Asp Ala Pro Ser His Asn Ser Glu Lys Lys Lys Thr Glu Gly Leu Val 
    850                 855                 860                 


Lys Leu Thr Pro Ile Asp Lys Arg Lys Cys Glu Arg Leu Leu Leu Phe 
865                 870                 875                 880 


Leu Tyr Cys His Glu Met Ser Leu Ala Phe Gln Asp Pro Val Pro Leu 
                885                 890                 895     


Thr Val Pro Asp Tyr Tyr Lys Ile Ile Lys Asn Pro Met Asp Leu Ser 
            900                 905                 910         


Thr Ile Lys Lys Arg Leu Gln Glu Asp Tyr Ser Met Tyr Ser Lys Pro 
        915                 920                 925             


Glu Asp Phe Val Ala Asp Phe Arg Leu Ile Phe Gln Asn Cys Ala Glu 
    930                 935                 940                 


Phe Asn Glu Pro Asp Ser Glu Val Ala Asn Ala Gly Ile Lys Leu Glu 
945                 950                 955                 960 


Asn Tyr Phe Glu Glu Leu Leu Lys Asn Leu Tyr Pro Glu Lys Arg Phe 
                965                 970                 975     


Pro Lys Pro Glu Phe Arg Asn Glu Ser Glu Asp Asn Lys Phe Ser Asp 
            980                 985                 990         


Asp Ser Asp Asp Asp Phe Val Gln  Pro Arg Lys Lys Arg  Leu Lys Ser 
        995                 1000                 1005             


Ile Glu  Glu Arg Gln Leu Leu  Lys 
    1010                 1015     

<210>  2416
<211>  8480
<212>  DNA
<213>  Homo sapiens

<400>  2416
gaggtgggcc agggggatga agagaaaggc ggggaggcaa gggcgggctg ggcgtattcc     60

acgagcgcct cggcggttgg cgaagcggac ggggtgcagc ctccccggtg cgaggaacgg    120

tctccgctga cagataccct ccttccggcc gcgccactcg ggaggcggat cccgtgggcc    180

tgaggaggct tcccccgccc ggtttgcttt ccctccctcg ctggcgctgc cgcgagtcca    240

ccgagcggcc tctgaggagc agccgcagga ggaggaggag gtcgtcgggg gcggcgggcg    300

gagaccgcgc tctcgcttcc ccggcggcgg caagggcagg acaatggagg tggcggtgga    360

gaaggcggtg gcggcggcgg cagcggcctc ggctgcggcc tccggggggc cctcggcggc    420

gccgagcggg gagaacgagg ccgagagtcg gcagggcccg gactcggagc gcggcggcga    480

ggcggcccgg ctcaacctgt tggacacttg cgccgtgtgc caccagaaca tccagagccg    540

ggcgcccaag ctgctgccct gcctgcactc tttctgccag cgctgcctgc ccgcgcccca    600

gcgctacctc atgctgcccg cgcccatgct gggctcggcc gagaccccgc cacccgtccc    660

tgcccccggc tcgccggtca gcggctcgtc gccgttcgcc acccaagttg gagtcattcg    720

ttgcccagtt tgcagccaag aatgtgcaga gagacacatc atagataact tttttgtgaa    780

ggacactact gaggttccca gcagtacagt agaaaagtca aatcaggtat gtacaagctg    840

tgaggacaac gcagaagcca atgggttttg tgtagagtgt gttgaatggc tctgcaagac    900

gtgtatcaga gctcatcaga gggtaaagtt cacaaaagac cacactgtca gacagaaaga    960

ggaagtatct ccagaggcag ttggtgtcac cagccagcga ccagtgtttt gtccttttca   1020

taaaaaggag cagctgaagc tgtactgtga gacatgtgac aaactgacat gtcgagactg   1080

tcagttgtta gaacataaag agcatagata ccaatttata gaagaagctt ttcagaatca   1140

gaaagtgatc atagatacac taatcaccaa actgatggaa aaaacaaaat acataaaatt   1200

cacaggaaat cagatccaaa acagaattat tgaagtaaat caaaatcaaa agcaggtgga   1260

acaggatatt aaagttgcta tatttacact gatggtagaa ataaataaaa aaggaaaagc   1320

tctactgcat cagttagaga gccttgcaaa ggaccatcgc atgaaactta tgcaacaaca   1380

acaggaagtg gctggactct ctaaacaatt ggagcatgtc atgcattttt ctaaatgggc   1440

agtttccagt ggcagcagta cagcattact ttatagcaaa cgactgatta cataccggtt   1500

acggcacctc cttcgtgcaa ggtgtgatgc atccccagtg accaacaaca ccatccaatt   1560

tcactgtgat cctagtttct gggctcaaaa tatcatcaac ttaggttctt tagtaatcga   1620

ggataaagag agccagccac aaatgcctaa gcagaatcct gtcgtggaac agaattcaca   1680

gccaccaagt ggtttatcat caaaccagtt atccaagttc ccaacacaga tcagcctagc   1740

tcaattacgg ctccagcata tgcagcaaca gcaaccgcct ccacgtttga taaactttca   1800

gaatcacagc cccaaaccca atggaccagt tcttcctcct catcctcaac aactgagata   1860

tccaccaaac cagaacatac cacgacaagc aataaagcca aaccccctac agatggcttt   1920

cttggctcaa caagccataa aacagtggca gatcagcagt ggacagggaa ccccatcaac   1980

taccaacagc acatcctcta ctccttccag ccccacgatt actagtgcag caggatatga   2040

tggaaaggct tttggttcac ctatgatcga tttgagctca ccagtgggag ggtcttataa   2100

tcttccctct cttccggata ttgactgttc aagtactatt atgctggaca atattgtgag   2160

gaaagatact aatatagatc atggccagcc aagaccaccc tcaaacagaa cggtccagtc   2220

accaaattca tcagtgccat ctccaggcct tgcaggacct gttactatga ctagtgtaca   2280

ccccccaata cgttcaccta gtgcctccag cgttggaagc cgaggaagct ctggctcttc   2340

cagcaaacca gcaggagctg actctacaca caaagtccca gtggtcatgc tggagccaat   2400

tcgaataaaa caagaaaaca gtggaccacc ggaaaattat gatttccctg ttgttatagt   2460

gaagcaagaa tcagatgaag aatctaggcc tcaaaatgcc aattatccaa gaagcatact   2520

cacctccctg ctcttaaata gcagtcagag ctctacttct gaggagactg tgctaagatc   2580

agatgcccct gatagtacag gagatcaacc tggacttcac caggacaatt cctcaaatgg   2640

aaagtctgaa tggttggatc cttcccagaa gtcacctctt catgttggag agacaaggaa   2700

agaggatgac cccaatgagg actggtgtgc agtttgtcaa aacggagggg aactcctctg   2760

ctgtgaaaag tgccccaaag tattccatct ttcttgtcat gtgcccacat tgacaaattt   2820

tccaagtgga gagtggattt gcactttctg ccgagactta tctaaaccag aagttgaata   2880

tgattgtgat gctcccagtc acaactcaga aaaaaagaaa actgaaggcc ttgttaagtt   2940

aacacctata gataaaagga agtgtgagcg cctactttta tttctttact gccatgaaat   3000

gagcctggct tttcaagacc ctgttcctct aactgtgcct gattattaca aaataattaa   3060

aaatccaatg gatttgtcaa ccatcaagaa aagactacaa gaagattatt ccatgtactc   3120

aaaacctgaa gattttgtag ctgattttag attgatcttt caaaactgtg ctgaattcaa   3180

tgagcctgat tcagaagtag ccaatgctgg tataaaactt gaaaattatt ttgaagaact   3240

tctaaagaac ctctatccag aaaaaaggtt tcccaaacca gaattcagga atgaatcaga   3300

agataataaa tttagtgatg attcagatga tgactttgta cagccccgga agaaacgcct   3360

caaaagcatt gaagaacgcc agttgcttaa ataatatgca gcaccactag cttgtgctgg   3420

tttttagatt tttttgtttt caaaaaaaca tttgtcagta atttaacatc actacaaaaa   3480

gaagagtttg tgactattct catctctgtt ttggacgttt actagacttt gatttcctta   3540

atagcccatt tctgttaacc tcttatcact aagaaagaaa ggaaagaagg agatgaatag   3600

aagaaagaaa atggaaagaa ggaaaaaagg aggatagaaa aaggatggaa gaaagaagca   3660

ttgaaaacaa agacattctt cccacttctt ggatttttaa accacagtct ggagtgatag   3720

ctactgtaga aaggaaatag actttgtatg aactctttaa gttgaaaagt aaaaaatata   3780

tgtggtttgg atgtgtgctt taattcagct ttagaaatta ataccactac ccgtgaatta   3840

tatggcctga caatatgaat taggtgtact gtactgaaga acagtactcc acaaacatgg   3900

gtggtaacaa gagttccatc ccaggaggcc aaacggtgca acagaagggt aggttagatg   3960

ctattaagaa ggcacttaat agtacatcat gtaagatggc aactgtatta aagaaaaatc   4020

cggaaaacaa atgtttgatt tttgtttttg tttttatctt gtctgtagag gtattttggt   4080

atagcaggtt ttcaaggcca ttttttatac atttctagat ctagattttc aacttcttcc   4140

actgagggaa gtatatacat ttgggtttgc tgtgtgtcta tgtgaggttt aattgtacag   4200

gtgatccttt tacaacaagc ctcattgttt gcagtatagc ttttagtgga actacccaaa   4260

atataaatac agcagcgtgc actgtatttg atgtgagggt tcttcatcat ataccctact   4320

gggcattaaa tataagttcc tctgaaaggg actcgttttt gtggttttca tctgtctata   4380

atttggaatg aaaatgtgtt gtaggatttt gggagcaggc agctgggggg aattaatagt   4440

gatttttttt ttttcctgaa gcatctatct catgtttttc ttttgagagt cagaacatca   4500

aacttaatct ttgatctgac ttctgatttt attcttctga ttgattgata gaggtacaaa   4560

agacttatct tctgaggaca agcatattct taatgtgcca gacctacccg gttcagctga   4620

tatagataga tagatagata gaagaaaatt gctgtgccat acattaatcc agcatttgac   4680

acaatatcta aatggtttgc cgaagttaat ctgtatttat aaaacattaa ctggagtaaa   4740

tttttctcct taggatgata gaataaaaag agctcacttg aaagaaggct attatttgca   4800

ttatatcacc tgccataaat ttaacataga agacttggtt ttatctacat ggctttactt   4860

cttaaagtgg aaaatatcct gtggctaatt cattgggttt tcaggtactg ctaaagataa   4920

aatacaggga gaaaataact tgttagcaat agatccccat tgtttatata tataggtctt   4980

gttcataata tgtcaattat gtattgttaa aaagtcctac tcacttttca aatatgtgtt   5040

acatggtaat gtttgtcatt gttgttttaa agttgcattt gacatttgtt ctccaaagag   5100

tgtttgaaca gattttgata acagtgcata caccttttgt ctttttttgc tccagcattt   5160

tatttttagc acagcagctg tggagctttt gctgataatt ttattgttgg tatcttagaa   5220

tactgttcgt ctgacagttt attcttccat acttgtctcc caagttaaaa cagagcaaaa   5280

cagataaatt attttgagaa tcatcacaaa agggagttag aacttgtgag actaaaacta   5340

taatttccta aatgtgacta atgaacccca aactgtcact attacattca gtgccatatt   5400

tatctttcaa aacagtattt gtttcaccct aaccatcttt ggctgaatga aaggcagttg   5460

agaaccatct tttggtcata cataatataa ttatattaaa agtaaagatc ggggctgggc   5520

gcagtggctc acacctgcaa tcccaccagc actttgggag gccaaggtgg gcggatcaca   5580

aagtcaagag ttcgagatca gcctggccaa cattgtgaaa ccccgcctct acaaaaaata   5640

caaaaattag ccggacatgg tggcgtgcaa ctgtaatccc aactactcag gaggctgaga   5700

caggagaatc acttgaacgc aggaggcaga agttgcagtg agccaagatc tcaccattgc   5760

actccagcct gagtgacaga gactcagtct caaaaacaaa aagtaaaggt cttgggtttc   5820

tctctgtaaa tagcctttgt gtaatggtct ttagattaat atcctttgac tttattaata   5880

agtacctgtg tgcccaggtg gatctcagct aagtcatcct taaattctgt tcaaatagaa   5940

ataaaccata aaatgagcct aactataacc cacactcact tatcaagcat tcccccaaaa   6000

gttcagtgcg attcaggtaa ccttgaccta aacttgtaca ctccggtgta catctttgac   6060

cataaactct gggagatttc cctctggatt tgggatcagg agcccagtag ggccccattg   6120

ctgaatgttt atcacacttc tggctagggc ttatggatga gcagaccacg taggagctag   6180

gatttactca gttccacctc actgacagct tttctaggtg ccaagcaact gacttttcct   6240

gtgtaaggaa gcccaagtac ttgaccagtg atatatatgg ccatggcaaa agtataaatg   6300

gatggatgta gaccatattc aacgcagaat acattttaga tcggtatctg gcattgtaat   6360

cattttgtct tttgaattaa catgccctgc ttgtcttttc tgaatggaag ggtaggaaag   6420

tggaaggtac taaaaaggaa aatgtagttt tagtttcttt tctaagctaa agaactggct   6480

ttactactgc tatattttac taccacatag tagtgtagat gtagtataac ttgcttagga   6540

atgctttcaa aaaggttacc tccatagtca aaaaaagggg gagtatacag ctgattgttg   6600

catttatgaa actgcatttc aatatgctat gctgttactg tgcttagaca cttccttacg   6660

tttgagttcc aaggagagag agtgagaaga ggaactcctt ttgctgagct ctggtccaaa   6720

ttaatgtgaa tccccaaagt aaattgctgc atatgaacaa caggttttag gtttaaattg   6780

aagatacatt cattttatat gtatttgttg tgaatgagag aaattgagtg atctgattgg   6840

ccattaaaat tatggtgaat gggtcgggcg cagtggctca cgcctgtaat cccagcactt   6900

tgggaggccg aggtgggtag atacctgagg tcaggagttt gagaccagcc tgaccaacat   6960

ggtgaaaccc catctctact aaaaatacca aaatcaccag ggtgtggtgg cccatgcctg   7020

taatcctagc tactcgggag gctgaggcag gagaatcggc ttgaacccag gaggcagagg   7080

ttgcagtgag ctgagatcgc accactgtag tccagcctgg gtgtcagagc aagactctgt   7140

cacaaaaaga aaaattatgg ggaatggccg ggcgcggtgg ctcacacctg taatcccagc   7200

actttgggag gccgaggtgg gtggatcacc tgaagtcagg agctcaagac cagcctggcc   7260

aacatggtga aaccccacct caacagaata tacaaaaaaa ttagctgggt gtggtggcgg   7320

gtgcctgtaa tctcagctac tttgggatgc tgaggcagga gaatagcttg aacccaggag   7380

gtggaggttg cagtgagtcg agattgcacc attgcactcc agcctgggca acaagagcaa   7440

aactctgtct caaaaaaaaa aaaaaatggt gaccatgcgt tcaaccatat aatttcttac   7500

tgaaattgag ctcctccttt tgaataacca tgtacatatt tttaaaagta ttttatagcc   7560

ctatgtaaat taatagttga tgtcttttta taaatgttta ttgcatattc atcttgaatg   7620

tgaatttact gttgtaattc acatactggt gtcatgtttc tgagtgagaa taatgctagt   7680

cagtcagatc acagattttt ctccatgaag gttttactta ttgagaggga catctgaggc   7740

agtagtcttc gtctttaatt tttgggggca gattggtgct ttggttttaa taaaaactaa   7800

ctttgatgga tttttactgt caatatttta ccacaaggat tttttaatag aaaaattact   7860

gaatgttact tcagcagagt tctatctact ttgagtctcc attactacta ctgttgttcc   7920

cctagctgta acattgatcc atataggggc aagctactag tccataaata gctgtaatag   7980

gaaaacagtt ttttaaaatt ctaacacgtg tatttcacca gccttaaaag atttaaaaaa   8040

aaatctgaca ggaaggaaag cgggtggtaa gtatcttgga ttattctgcc tcataccagc   8100

cactcccaaa gtaggaggac caaagatgcc atgaagactt ctagttgtct ggaagttatt   8160

tggggaaggg gggaaagaca cagagtgggg acctttggaa gtcattttaa aaatttagct   8220

atgttaattc cacttgtaaa gtttgaaagg ttttgattct tgtaatttct gagaattact   8280

atgttttaaa tttactattg gatatttaac agatctttca tggggccaac ctatttgctt   8340

ccttaatttt caaattaagt cctaatttga gtcctaaaaa aatctttcct tgttagttgc   8400

aagttaaaca tttaataaaa ttattttccc acgttttcac atgtggtatg gaataaaggc   8460

tgttttaaca ttccctgcga                                               8480


<210>  2417
<211>  1016
<212>  PRT
<213>  Homo sapiens

<400>  2417


Met Glu Val Ala Val Glu Lys Ala Val Ala Ala Ala Ala Ala Ala Ser 
1               5                   10                  15      


Ala Ala Ala Ser Gly Gly Pro Ser Ala Ala Pro Ser Gly Glu Asn Glu 
            20                  25                  30          


Ala Glu Ser Arg Gln Gly Pro Asp Ser Glu Arg Gly Gly Glu Ala Ala 
        35                  40                  45              


Arg Leu Asn Leu Leu Asp Thr Cys Ala Val Cys His Gln Asn Ile Gln 
    50                  55                  60                  


Ser Arg Ala Pro Lys Leu Leu Pro Cys Leu His Ser Phe Cys Gln Arg 
65                  70                  75                  80  


Cys Leu Pro Ala Pro Gln Arg Tyr Leu Met Leu Pro Ala Pro Met Leu 
                85                  90                  95      


Gly Ser Ala Glu Thr Pro Pro Pro Val Pro Ala Pro Gly Ser Pro Val 
            100                 105                 110         


Ser Gly Ser Ser Pro Phe Ala Thr Gln Val Gly Val Ile Arg Cys Pro 
        115                 120                 125             


Val Cys Ser Gln Glu Cys Ala Glu Arg His Ile Ile Asp Asn Phe Phe 
    130                 135                 140                 


Val Lys Asp Thr Thr Glu Val Pro Ser Ser Thr Val Glu Lys Ser Asn 
145                 150                 155                 160 


Gln Val Cys Thr Ser Cys Glu Asp Asn Ala Glu Ala Asn Gly Phe Cys 
                165                 170                 175     


Val Glu Cys Val Glu Trp Leu Cys Lys Thr Cys Ile Arg Ala His Gln 
            180                 185                 190         


Arg Val Lys Phe Thr Lys Asp His Thr Val Arg Gln Lys Glu Glu Val 
        195                 200                 205             


Ser Pro Glu Ala Val Gly Val Thr Ser Gln Arg Pro Val Phe Cys Pro 
    210                 215                 220                 


Phe His Lys Lys Glu Gln Leu Lys Leu Tyr Cys Glu Thr Cys Asp Lys 
225                 230                 235                 240 


Leu Thr Cys Arg Asp Cys Gln Leu Leu Glu His Lys Glu His Arg Tyr 
                245                 250                 255     


Gln Phe Ile Glu Glu Ala Phe Gln Asn Gln Lys Val Ile Ile Asp Thr 
            260                 265                 270         


Leu Ile Thr Lys Leu Met Glu Lys Thr Lys Tyr Ile Lys Phe Thr Gly 
        275                 280                 285             


Asn Gln Ile Gln Asn Arg Ile Ile Glu Val Asn Gln Asn Gln Lys Gln 
    290                 295                 300                 


Val Glu Gln Asp Ile Lys Val Ala Ile Phe Thr Leu Met Val Glu Ile 
305                 310                 315                 320 


Asn Lys Lys Gly Lys Ala Leu Leu His Gln Leu Glu Ser Leu Ala Lys 
                325                 330                 335     


Asp His Arg Met Lys Leu Met Gln Gln Gln Gln Glu Val Ala Gly Leu 
            340                 345                 350         


Ser Lys Gln Leu Glu His Val Met His Phe Ser Lys Trp Ala Val Ser 
        355                 360                 365             


Ser Gly Ser Ser Thr Ala Leu Leu Tyr Ser Lys Arg Leu Ile Thr Tyr 
    370                 375                 380                 


Arg Leu Arg His Leu Leu Arg Ala Arg Cys Asp Ala Ser Pro Val Thr 
385                 390                 395                 400 


Asn Asn Thr Ile Gln Phe His Cys Asp Pro Ser Phe Trp Ala Gln Asn 
                405                 410                 415     


Ile Ile Asn Leu Gly Ser Leu Val Ile Glu Asp Lys Glu Ser Gln Pro 
            420                 425                 430         


Gln Met Pro Lys Gln Asn Pro Val Val Glu Gln Asn Ser Gln Pro Pro 
        435                 440                 445             


Ser Gly Leu Ser Ser Asn Gln Leu Ser Lys Phe Pro Thr Gln Ile Ser 
    450                 455                 460                 


Leu Ala Gln Leu Arg Leu Gln His Met Gln Gln Gln Gln Pro Pro Pro 
465                 470                 475                 480 


Arg Leu Ile Asn Phe Gln Asn His Ser Pro Lys Pro Asn Gly Pro Val 
                485                 490                 495     


Leu Pro Pro His Pro Gln Gln Leu Arg Tyr Pro Pro Asn Gln Asn Ile 
            500                 505                 510         


Pro Arg Gln Ala Ile Lys Pro Asn Pro Leu Gln Met Ala Phe Leu Ala 
        515                 520                 525             


Gln Gln Ala Ile Lys Gln Trp Gln Ile Ser Ser Gly Gln Gly Thr Pro 
    530                 535                 540                 


Ser Thr Thr Asn Ser Thr Ser Ser Thr Pro Ser Ser Pro Thr Ile Thr 
545                 550                 555                 560 


Ser Ala Ala Gly Tyr Asp Gly Lys Ala Phe Gly Ser Pro Met Ile Asp 
                565                 570                 575     


Leu Ser Ser Pro Val Gly Gly Ser Tyr Asn Leu Pro Ser Leu Pro Asp 
            580                 585                 590         


Ile Asp Cys Ser Ser Thr Ile Met Leu Asp Asn Ile Val Arg Lys Asp 
        595                 600                 605             


Thr Asn Ile Asp His Gly Gln Pro Arg Pro Pro Ser Asn Arg Thr Val 
    610                 615                 620                 


Gln Ser Pro Asn Ser Ser Val Pro Ser Pro Gly Leu Ala Gly Pro Val 
625                 630                 635                 640 


Thr Met Thr Ser Val His Pro Pro Ile Arg Ser Pro Ser Ala Ser Ser 
                645                 650                 655     


Val Gly Ser Arg Gly Ser Ser Gly Ser Ser Ser Lys Pro Ala Gly Ala 
            660                 665                 670         


Asp Ser Thr His Lys Val Pro Val Val Met Leu Glu Pro Ile Arg Ile 
        675                 680                 685             


Lys Gln Glu Asn Ser Gly Pro Pro Glu Asn Tyr Asp Phe Pro Val Val 
    690                 695                 700                 


Ile Val Lys Gln Glu Ser Asp Glu Glu Ser Arg Pro Gln Asn Ala Asn 
705                 710                 715                 720 


Tyr Pro Arg Ser Ile Leu Thr Ser Leu Leu Leu Asn Ser Ser Gln Ser 
                725                 730                 735     


Ser Thr Ser Glu Glu Thr Val Leu Arg Ser Asp Ala Pro Asp Ser Thr 
            740                 745                 750         


Gly Asp Gln Pro Gly Leu His Gln Asp Asn Ser Ser Asn Gly Lys Ser 
        755                 760                 765             


Glu Trp Leu Asp Pro Ser Gln Lys Ser Pro Leu His Val Gly Glu Thr 
    770                 775                 780                 


Arg Lys Glu Asp Asp Pro Asn Glu Asp Trp Cys Ala Val Cys Gln Asn 
785                 790                 795                 800 


Gly Gly Glu Leu Leu Cys Cys Glu Lys Cys Pro Lys Val Phe His Leu 
                805                 810                 815     


Ser Cys His Val Pro Thr Leu Thr Asn Phe Pro Ser Gly Glu Trp Ile 
            820                 825                 830         


Cys Thr Phe Cys Arg Asp Leu Ser Lys Pro Glu Val Glu Tyr Asp Cys 
        835                 840                 845             


Asp Ala Pro Ser His Asn Ser Glu Lys Lys Lys Thr Glu Gly Leu Val 
    850                 855                 860                 


Lys Leu Thr Pro Ile Asp Lys Arg Lys Cys Glu Arg Leu Leu Leu Phe 
865                 870                 875                 880 


Leu Tyr Cys His Glu Met Ser Leu Ala Phe Gln Asp Pro Val Pro Leu 
                885                 890                 895     


Thr Val Pro Asp Tyr Tyr Lys Ile Ile Lys Asn Pro Met Asp Leu Ser 
            900                 905                 910         


Thr Ile Lys Lys Arg Leu Gln Glu Asp Tyr Ser Met Tyr Ser Lys Pro 
        915                 920                 925             


Glu Asp Phe Val Ala Asp Phe Arg Leu Ile Phe Gln Asn Cys Ala Glu 
    930                 935                 940                 


Phe Asn Glu Pro Asp Ser Glu Val Ala Asn Ala Gly Ile Lys Leu Glu 
945                 950                 955                 960 


Asn Tyr Phe Glu Glu Leu Leu Lys Asn Leu Tyr Pro Glu Lys Arg Phe 
                965                 970                 975     


Pro Lys Pro Glu Phe Arg Asn Glu Ser Glu Asp Asn Lys Phe Ser Asp 
            980                 985                 990         


Asp Ser Asp Asp Asp Phe Val Gln  Pro Arg Lys Lys Arg  Leu Lys Ser 
        995                 1000                 1005             


Ile Glu  Glu Arg Gln Leu Leu  Lys 
    1010                 1015     

<210>  2418
<211>  8582
<212>  DNA
<213>  Homo sapiens

<400>  2418
gaggtgggcc agggggatga agagaaaggc ggggaggcaa gggcgggctg ggcgtattcc     60

acgagcgcct cggcggttgg cgaagcggac ggggtgcagc ctccccggtg cgaggaacgg    120

tctccgctga cagataccct ccttccggcc gcgccactcg ggaggcggat cccgtgggcc    180

tgaggaggct tcccccgccc ggtttgcttt ccctccctcg ctggcgctgc cgcgagtcca    240

ccgagcggcc tctgaggagc agccgcagga ggaggaggag gtcgtcgggg gcggcgggcg    300

gagaccgcgc tctcgcttcc ccggcggcgg caagggcagg acaatggagg tggcggtgga    360

gaaggcggtg gcggcggcgg cagcggcctc ggctgcggcc tccggggggc cctcggcggc    420

gccgagcggg gagaacgagg ccgagagtcg gcagggcccg gactcggagc gcggcggcga    480

ggcggcccgg ctcaacctgt tggacacttg cgccgtgtgc caccagaaca tccagagccg    540

ggcgcccaag ctgctgccct gcctgcactc tttctgccag cgctgcctgc ccgcgcccca    600

gcgctacctc atgctgcccg cgcccatgct gggctcggcc gagaccccgc cacccgtccc    660

tgcccccggc tcgccggtca gcggctcgtc gccgttcgcc acccaagttg gagtcattcg    720

ttgcccagtt tgcagccaag aatgtgcaga gagacacatc atagataact tttttgtgaa    780

ggacactact gaggttccca gcagtacagt agaaaagtca aatcaggtat gtacaagctg    840

tgaggacaac gcagaagcca atgggttttg tgtagagtgt gttgaatggc tctgcaagac    900

gtgtatcaga gctcatcaga gggtaaagtt cacaaaagac cacactgtca gacagaaaga    960

ggaagtatct ccagaggcag ttggtgtcac cagccagcga ccagtgtttt gtccttttca   1020

taaaaaggag cagctgaagc tgtactgtga gacatgtgac aaactgacat gtcgagactg   1080

tcagttgtta gaacataaag agcatagata ccaatttata gaagaagctt ttcagaatca   1140

gaaagtgatc atagatacac taatcaccaa actgatggaa aaaacaaaat acataaaatt   1200

cacaggaaat cagatccaaa acagaattat tgaagtaaat caaaatcaaa agcaggtgga   1260

acaggatatt aaagttgcta tatttacact gatggtagaa ataaataaaa aaggaaaagc   1320

tctactgcat cagttagaga gccttgcaaa ggaccatcgc atgaaactta tgcaacaaca   1380

acaggaagtg gctggactct ctaaacaatt ggagcatgtc atgcattttt ctaaatgggc   1440

agtttccagt ggcagcagta cagcattact ttatagcaaa cgactgatta cataccggtt   1500

acggcacctc cttcgtgcaa ggtgtgatgc atccccagtg accaacaaca ccatccaatt   1560

tcactgtgat cctagtttct gggctcaaaa tatcatcaac ttaggttctt tagtaatcga   1620

ggataaagag agccagccac aaatgcctaa gcagaatcct gtcgtggaac agaattcaca   1680

gccaccaagt ggtttatcat caaaccagtt atccaagttc ccaacacaga tcagcctagc   1740

tcaattacgg ctccagcata tgcagcaaca ggtaatggct cagaggcaac aggtgcaacg   1800

gaggccagca cctgtgggtt taccaaaccc tagaatgcag gggcccatcc agcaaccttc   1860

catctctcat cagcaaccgc ctccacgttt gataaacttt cagaatcaca gccccaaacc   1920

caatggacca gttcttcctc ctcatcctca acaactgaga tatccaccaa accagaacat   1980

accacgacaa gcaataaagc caaaccccct acagatggct ttcttggctc aacaagccat   2040

aaaacagtgg cagatcagca gtggacaggg aaccccatca actaccaaca gcacatcctc   2100

tactccttcc agccccacga ttactagtgc agcaggatat gatggaaagg cttttggttc   2160

acctatgatc gatttgagct caccagtggg agggtcttat aatcttccct ctcttccgga   2220

tattgactgt tcaagtacta ttatgctgga caatattgtg aggaaagata ctaatataga   2280

tcatggccag ccaagaccac cctcaaacag aacggtccag tcaccaaatt catcagtgcc   2340

atctccaggc cttgcaggac ctgttactat gactagtgta caccccccaa tacgttcacc   2400

tagtgcctcc agcgttggaa gccgaggaag ctctggctct tccagcaaac cagcaggagc   2460

tgactctaca cacaaagtcc cagtggtcat gctggagcca attcgaataa aacaagaaaa   2520

cagtggacca ccggaaaatt atgatttccc tgttgttata gtgaagcaag aatcagatga   2580

agaatctagg cctcaaaatg ccaattatcc aagaagcata ctcacctccc tgctcttaaa   2640

tagcagtcag agctctactt ctgaggagac tgtgctaaga tcagatgccc ctgatagtac   2700

aggagatcaa cctggacttc accaggacaa ttcctcaaat ggaaagtctg aatggttgga   2760

tccttcccag aagtcacctc ttcatgttgg agagacaagg aaagaggatg accccaatga   2820

ggactggtgt gcagtttgtc aaaacggagg ggaactcctc tgctgtgaaa agtgccccaa   2880

agtattccat ctttcttgtc atgtgcccac attgacaaat tttccaagtg gagagtggat   2940

ttgcactttc tgccgagact tatctaaacc agaagttgaa tatgattgtg atgctcccag   3000

tcacaactca gaaaaaaaga aaactgaagg ccttgttaag ttaacaccta tagataaaag   3060

gaagtgtgag cgcctacttt tatttcttta ctgccatgaa atgagcctgg cttttcaaga   3120

ccctgttcct ctaactgtgc ctgattatta caaaataatt aaaaatccaa tggatttgtc   3180

aaccatcaag aaaagactac aagaagatta ttccatgtac tcaaaacctg aagattttgt   3240

agctgatttt agattgatct ttcaaaactg tgctgaattc aatgagcctg attcagaagt   3300

agccaatgct ggtataaaac ttgaaaatta ttttgaagaa cttctaaaga acctctatcc   3360

agaaaaaagg tttcccaaac cagaattcag gaatgaatca gaagataata aatttagtga   3420

tgattcagat gatgactttg tacagccccg gaagaaacgc ctcaaaagca ttgaagaacg   3480

ccagttgctt aaataatatg cagcaccact agcttgtgct ggtttttaga tttttttgtt   3540

ttcaaaaaaa catttgtcag taatttaaca tcactacaaa aagaagagtt tgtgactatt   3600

ctcatctctg ttttggacgt ttactagact ttgatttcct taatagccca tttctgttaa   3660

cctcttatca ctaagaaaga aaggaaagaa ggagatgaat agaagaaaga aaatggaaag   3720

aaggaaaaaa ggaggataga aaaaggatgg aagaaagaag cattgaaaac aaagacattc   3780

ttcccacttc ttggattttt aaaccacagt ctggagtgat agctactgta gaaaggaaat   3840

agactttgta tgaactcttt aagttgaaaa gtaaaaaata tatgtggttt ggatgtgtgc   3900

tttaattcag ctttagaaat taataccact acccgtgaat tatatggcct gacaatatga   3960

attaggtgta ctgtactgaa gaacagtact ccacaaacat gggtggtaac aagagttcca   4020

tcccaggagg ccaaacggtg caacagaagg gtaggttaga tgctattaag aaggcactta   4080

atagtacatc atgtaagatg gcaactgtat taaagaaaaa tccggaaaac aaatgtttga   4140

tttttgtttt tgtttttatc ttgtctgtag aggtattttg gtatagcagg ttttcaaggc   4200

cattttttat acatttctag atctagattt tcaacttctt ccactgaggg aagtatatac   4260

atttgggttt gctgtgtgtc tatgtgaggt ttaattgtac aggtgatcct tttacaacaa   4320

gcctcattgt ttgcagtata gcttttagtg gaactaccca aaatataaat acagcagcgt   4380

gcactgtatt tgatgtgagg gttcttcatc atatacccta ctgggcatta aatataagtt   4440

cctctgaaag ggactcgttt ttgtggtttt catctgtcta taatttggaa tgaaaatgtg   4500

ttgtaggatt ttgggagcag gcagctgggg ggaattaata gtgatttttt ttttttcctg   4560

aagcatctat ctcatgtttt tcttttgaga gtcagaacat caaacttaat ctttgatctg   4620

acttctgatt ttattcttct gattgattga tagaggtaca aaagacttat cttctgagga   4680

caagcatatt cttaatgtgc cagacctacc cggttcagct gatatagata gatagataga   4740

tagaagaaaa ttgctgtgcc atacattaat ccagcatttg acacaatatc taaatggttt   4800

gccgaagtta atctgtattt ataaaacatt aactggagta aatttttctc cttaggatga   4860

tagaataaaa agagctcact tgaaagaagg ctattatttg cattatatca cctgccataa   4920

atttaacata gaagacttgg ttttatctac atggctttac ttcttaaagt ggaaaatatc   4980

ctgtggctaa ttcattgggt tttcaggtac tgctaaagat aaaatacagg gagaaaataa   5040

cttgttagca atagatcccc attgtttata tatataggtc ttgttcataa tatgtcaatt   5100

atgtattgtt aaaaagtcct actcactttt caaatatgtg ttacatggta atgtttgtca   5160

ttgttgtttt aaagttgcat ttgacatttg ttctccaaag agtgtttgaa cagattttga   5220

taacagtgca tacacctttt gtcttttttt gctccagcat tttattttta gcacagcagc   5280

tgtggagctt ttgctgataa ttttattgtt ggtatcttag aatactgttc gtctgacagt   5340

ttattcttcc atacttgtct cccaagttaa aacagagcaa aacagataaa ttattttgag   5400

aatcatcaca aaagggagtt agaacttgtg agactaaaac tataatttcc taaatgtgac   5460

taatgaaccc caaactgtca ctattacatt cagtgccata tttatctttc aaaacagtat   5520

ttgtttcacc ctaaccatct ttggctgaat gaaaggcagt tgagaaccat cttttggtca   5580

tacataatat aattatatta aaagtaaaga tcggggctgg gcgcagtggc tcacacctgc   5640

aatcccacca gcactttggg aggccaaggt gggcggatca caaagtcaag agttcgagat   5700

cagcctggcc aacattgtga aaccccgcct ctacaaaaaa tacaaaaatt agccggacat   5760

ggtggcgtgc aactgtaatc ccaactactc aggaggctga gacaggagaa tcacttgaac   5820

gcaggaggca gaagttgcag tgagccaaga tctcaccatt gcactccagc ctgagtgaca   5880

gagactcagt ctcaaaaaca aaaagtaaag gtcttgggtt tctctctgta aatagccttt   5940

gtgtaatggt ctttagatta atatcctttg actttattaa taagtacctg tgtgcccagg   6000

tggatctcag ctaagtcatc cttaaattct gttcaaatag aaataaacca taaaatgagc   6060

ctaactataa cccacactca cttatcaagc attcccccaa aagttcagtg cgattcaggt   6120

aaccttgacc taaacttgta cactccggtg tacatctttg accataaact ctgggagatt   6180

tccctctgga tttgggatca ggagcccagt agggccccat tgctgaatgt ttatcacact   6240

tctggctagg gcttatggat gagcagacca cgtaggagct aggatttact cagttccacc   6300

tcactgacag cttttctagg tgccaagcaa ctgacttttc ctgtgtaagg aagcccaagt   6360

acttgaccag tgatatatat ggccatggca aaagtataaa tggatggatg tagaccatat   6420

tcaacgcaga atacatttta gatcggtatc tggcattgta atcattttgt cttttgaatt   6480

aacatgccct gcttgtcttt tctgaatgga agggtaggaa agtggaaggt actaaaaagg   6540

aaaatgtagt tttagtttct tttctaagct aaagaactgg ctttactact gctatatttt   6600

actaccacat agtagtgtag atgtagtata acttgcttag gaatgctttc aaaaaggtta   6660

cctccatagt caaaaaaagg gggagtatac agctgattgt tgcatttatg aaactgcatt   6720

tcaatatgct atgctgttac tgtgcttaga cacttcctta cgtttgagtt ccaaggagag   6780

agagtgagaa gaggaactcc ttttgctgag ctctggtcca aattaatgtg aatccccaaa   6840

gtaaattgct gcatatgaac aacaggtttt aggtttaaat tgaagataca ttcattttat   6900

atgtatttgt tgtgaatgag agaaattgag tgatctgatt ggccattaaa attatggtga   6960

atgggtcggg cgcagtggct cacgcctgta atcccagcac tttgggaggc cgaggtgggt   7020

agatacctga ggtcaggagt ttgagaccag cctgaccaac atggtgaaac cccatctcta   7080

ctaaaaatac caaaatcacc agggtgtggt ggcccatgcc tgtaatccta gctactcggg   7140

aggctgaggc aggagaatcg gcttgaaccc aggaggcaga ggttgcagtg agctgagatc   7200

gcaccactgt agtccagcct gggtgtcaga gcaagactct gtcacaaaaa gaaaaattat   7260

ggggaatggc cgggcgcggt ggctcacacc tgtaatccca gcactttggg aggccgaggt   7320

gggtggatca cctgaagtca ggagctcaag accagcctgg ccaacatggt gaaaccccac   7380

ctcaacagaa tatacaaaaa aattagctgg gtgtggtggc gggtgcctgt aatctcagct   7440

actttgggat gctgaggcag gagaatagct tgaacccagg aggtggaggt tgcagtgagt   7500

cgagattgca ccattgcact ccagcctggg caacaagagc aaaactctgt ctcaaaaaaa   7560

aaaaaaaatg gtgaccatgc gttcaaccat ataatttctt actgaaattg agctcctcct   7620

tttgaataac catgtacata tttttaaaag tattttatag ccctatgtaa attaatagtt   7680

gatgtctttt tataaatgtt tattgcatat tcatcttgaa tgtgaattta ctgttgtaat   7740

tcacatactg gtgtcatgtt tctgagtgag aataatgcta gtcagtcaga tcacagattt   7800

ttctccatga aggttttact tattgagagg gacatctgag gcagtagtct tcgtctttaa   7860

tttttggggg cagattggtg ctttggtttt aataaaaact aactttgatg gatttttact   7920

gtcaatattt taccacaagg attttttaat agaaaaatta ctgaatgtta cttcagcaga   7980

gttctatcta ctttgagtct ccattactac tactgttgtt cccctagctg taacattgat   8040

ccatataggg gcaagctact agtccataaa tagctgtaat aggaaaacag ttttttaaaa   8100

ttctaacacg tgtatttcac cagccttaaa agatttaaaa aaaaatctga caggaaggaa   8160

agcgggtggt aagtatcttg gattattctg cctcatacca gccactccca aagtaggagg   8220

accaaagatg ccatgaagac ttctagttgt ctggaagtta tttggggaag gggggaaaga   8280

cacagagtgg ggacctttgg aagtcatttt aaaaatttag ctatgttaat tccacttgta   8340

aagtttgaaa ggttttgatt cttgtaattt ctgagaatta ctatgtttta aatttactat   8400

tggatattta acagatcttt catggggcca acctatttgc ttccttaatt ttcaaattaa   8460

gtcctaattt gagtcctaaa aaaatctttc cttgttagtt gcaagttaaa catttaataa   8520

aattattttc ccacgttttc acatgtggta tggaataaag gctgttttaa cattccctgc   8580

ga                                                                  8582


<210>  2419
<211>  1050
<212>  PRT
<213>  Homo sapiens

<400>  2419


Met Glu Val Ala Val Glu Lys Ala Val Ala Ala Ala Ala Ala Ala Ser 
1               5                   10                  15      


Ala Ala Ala Ser Gly Gly Pro Ser Ala Ala Pro Ser Gly Glu Asn Glu 
            20                  25                  30          


Ala Glu Ser Arg Gln Gly Pro Asp Ser Glu Arg Gly Gly Glu Ala Ala 
        35                  40                  45              


Arg Leu Asn Leu Leu Asp Thr Cys Ala Val Cys His Gln Asn Ile Gln 
    50                  55                  60                  


Ser Arg Ala Pro Lys Leu Leu Pro Cys Leu His Ser Phe Cys Gln Arg 
65                  70                  75                  80  


Cys Leu Pro Ala Pro Gln Arg Tyr Leu Met Leu Pro Ala Pro Met Leu 
                85                  90                  95      


Gly Ser Ala Glu Thr Pro Pro Pro Val Pro Ala Pro Gly Ser Pro Val 
            100                 105                 110         


Ser Gly Ser Ser Pro Phe Ala Thr Gln Val Gly Val Ile Arg Cys Pro 
        115                 120                 125             


Val Cys Ser Gln Glu Cys Ala Glu Arg His Ile Ile Asp Asn Phe Phe 
    130                 135                 140                 


Val Lys Asp Thr Thr Glu Val Pro Ser Ser Thr Val Glu Lys Ser Asn 
145                 150                 155                 160 


Gln Val Cys Thr Ser Cys Glu Asp Asn Ala Glu Ala Asn Gly Phe Cys 
                165                 170                 175     


Val Glu Cys Val Glu Trp Leu Cys Lys Thr Cys Ile Arg Ala His Gln 
            180                 185                 190         


Arg Val Lys Phe Thr Lys Asp His Thr Val Arg Gln Lys Glu Glu Val 
        195                 200                 205             


Ser Pro Glu Ala Val Gly Val Thr Ser Gln Arg Pro Val Phe Cys Pro 
    210                 215                 220                 


Phe His Lys Lys Glu Gln Leu Lys Leu Tyr Cys Glu Thr Cys Asp Lys 
225                 230                 235                 240 


Leu Thr Cys Arg Asp Cys Gln Leu Leu Glu His Lys Glu His Arg Tyr 
                245                 250                 255     


Gln Phe Ile Glu Glu Ala Phe Gln Asn Gln Lys Val Ile Ile Asp Thr 
            260                 265                 270         


Leu Ile Thr Lys Leu Met Glu Lys Thr Lys Tyr Ile Lys Phe Thr Gly 
        275                 280                 285             


Asn Gln Ile Gln Asn Arg Ile Ile Glu Val Asn Gln Asn Gln Lys Gln 
    290                 295                 300                 


Val Glu Gln Asp Ile Lys Val Ala Ile Phe Thr Leu Met Val Glu Ile 
305                 310                 315                 320 


Asn Lys Lys Gly Lys Ala Leu Leu His Gln Leu Glu Ser Leu Ala Lys 
                325                 330                 335     


Asp His Arg Met Lys Leu Met Gln Gln Gln Gln Glu Val Ala Gly Leu 
            340                 345                 350         


Ser Lys Gln Leu Glu His Val Met His Phe Ser Lys Trp Ala Val Ser 
        355                 360                 365             


Ser Gly Ser Ser Thr Ala Leu Leu Tyr Ser Lys Arg Leu Ile Thr Tyr 
    370                 375                 380                 


Arg Leu Arg His Leu Leu Arg Ala Arg Cys Asp Ala Ser Pro Val Thr 
385                 390                 395                 400 


Asn Asn Thr Ile Gln Phe His Cys Asp Pro Ser Phe Trp Ala Gln Asn 
                405                 410                 415     


Ile Ile Asn Leu Gly Ser Leu Val Ile Glu Asp Lys Glu Ser Gln Pro 
            420                 425                 430         


Gln Met Pro Lys Gln Asn Pro Val Val Glu Gln Asn Ser Gln Pro Pro 
        435                 440                 445             


Ser Gly Leu Ser Ser Asn Gln Leu Ser Lys Phe Pro Thr Gln Ile Ser 
    450                 455                 460                 


Leu Ala Gln Leu Arg Leu Gln His Met Gln Gln Gln Val Met Ala Gln 
465                 470                 475                 480 


Arg Gln Gln Val Gln Arg Arg Pro Ala Pro Val Gly Leu Pro Asn Pro 
                485                 490                 495     


Arg Met Gln Gly Pro Ile Gln Gln Pro Ser Ile Ser His Gln Gln Pro 
            500                 505                 510         


Pro Pro Arg Leu Ile Asn Phe Gln Asn His Ser Pro Lys Pro Asn Gly 
        515                 520                 525             


Pro Val Leu Pro Pro His Pro Gln Gln Leu Arg Tyr Pro Pro Asn Gln 
    530                 535                 540                 


Asn Ile Pro Arg Gln Ala Ile Lys Pro Asn Pro Leu Gln Met Ala Phe 
545                 550                 555                 560 


Leu Ala Gln Gln Ala Ile Lys Gln Trp Gln Ile Ser Ser Gly Gln Gly 
                565                 570                 575     


Thr Pro Ser Thr Thr Asn Ser Thr Ser Ser Thr Pro Ser Ser Pro Thr 
            580                 585                 590         


Ile Thr Ser Ala Ala Gly Tyr Asp Gly Lys Ala Phe Gly Ser Pro Met 
        595                 600                 605             


Ile Asp Leu Ser Ser Pro Val Gly Gly Ser Tyr Asn Leu Pro Ser Leu 
    610                 615                 620                 


Pro Asp Ile Asp Cys Ser Ser Thr Ile Met Leu Asp Asn Ile Val Arg 
625                 630                 635                 640 


Lys Asp Thr Asn Ile Asp His Gly Gln Pro Arg Pro Pro Ser Asn Arg 
                645                 650                 655     


Thr Val Gln Ser Pro Asn Ser Ser Val Pro Ser Pro Gly Leu Ala Gly 
            660                 665                 670         


Pro Val Thr Met Thr Ser Val His Pro Pro Ile Arg Ser Pro Ser Ala 
        675                 680                 685             


Ser Ser Val Gly Ser Arg Gly Ser Ser Gly Ser Ser Ser Lys Pro Ala 
    690                 695                 700                 


Gly Ala Asp Ser Thr His Lys Val Pro Val Val Met Leu Glu Pro Ile 
705                 710                 715                 720 


Arg Ile Lys Gln Glu Asn Ser Gly Pro Pro Glu Asn Tyr Asp Phe Pro 
                725                 730                 735     


Val Val Ile Val Lys Gln Glu Ser Asp Glu Glu Ser Arg Pro Gln Asn 
            740                 745                 750         


Ala Asn Tyr Pro Arg Ser Ile Leu Thr Ser Leu Leu Leu Asn Ser Ser 
        755                 760                 765             


Gln Ser Ser Thr Ser Glu Glu Thr Val Leu Arg Ser Asp Ala Pro Asp 
    770                 775                 780                 


Ser Thr Gly Asp Gln Pro Gly Leu His Gln Asp Asn Ser Ser Asn Gly 
785                 790                 795                 800 


Lys Ser Glu Trp Leu Asp Pro Ser Gln Lys Ser Pro Leu His Val Gly 
                805                 810                 815     


Glu Thr Arg Lys Glu Asp Asp Pro Asn Glu Asp Trp Cys Ala Val Cys 
            820                 825                 830         


Gln Asn Gly Gly Glu Leu Leu Cys Cys Glu Lys Cys Pro Lys Val Phe 
        835                 840                 845             


His Leu Ser Cys His Val Pro Thr Leu Thr Asn Phe Pro Ser Gly Glu 
    850                 855                 860                 


Trp Ile Cys Thr Phe Cys Arg Asp Leu Ser Lys Pro Glu Val Glu Tyr 
865                 870                 875                 880 


Asp Cys Asp Ala Pro Ser His Asn Ser Glu Lys Lys Lys Thr Glu Gly 
                885                 890                 895     


Leu Val Lys Leu Thr Pro Ile Asp Lys Arg Lys Cys Glu Arg Leu Leu 
            900                 905                 910         


Leu Phe Leu Tyr Cys His Glu Met Ser Leu Ala Phe Gln Asp Pro Val 
        915                 920                 925             


Pro Leu Thr Val Pro Asp Tyr Tyr Lys Ile Ile Lys Asn Pro Met Asp 
    930                 935                 940                 


Leu Ser Thr Ile Lys Lys Arg Leu Gln Glu Asp Tyr Ser Met Tyr Ser 
945                 950                 955                 960 


Lys Pro Glu Asp Phe Val Ala Asp Phe Arg Leu Ile Phe Gln Asn Cys 
                965                 970                 975     


Ala Glu Phe Asn Glu Pro Asp Ser Glu Val Ala Asn Ala Gly Ile Lys 
            980                 985                 990         


Leu Glu Asn Tyr Phe Glu Glu Leu  Leu Lys Asn Leu Tyr  Pro Glu Lys 
        995                 1000                 1005             


Arg Phe  Pro Lys Pro Glu Phe  Arg Asn Glu Ser Glu  Asp Asn Lys 
    1010                 1015                 1020             


Phe Ser  Asp Asp Ser Asp Asp  Asp Phe Val Gln Pro  Arg Lys Lys 
    1025                 1030                 1035             


Arg Leu  Lys Ser Ile Glu Glu  Arg Gln Leu Leu Lys  
    1040                 1045                 1050 

<210>  2420
<211>  466
<212>  DNA
<213>  Homo sapiens

<400>  2420
gcctccccgg tgcgaggaac ggtctccgct gacagatacc ctccttccgg ccgcgccact     60

cgggaggcgg atcccgtggg cctgaggagg cttcccccgc ccggtttgct ttccctccct    120

cgctggcgct gccgcgagtc caccgagcgg cctctgagga gcagccgcag gaggaggagg    180

aggtcgtcgg gggcggcggg cggagaccgc gctctcgctt ccccggcggc ggcaagggca    240

ggacaatgga cggcggcgcc gagcggggag aacgaggccg agagtcggca gggcccggac    300

tcggagcgcg gcggcgaggc ggcccggctc aacctgttgg acacttgcgc cgtgtgccac    360

cagaacatcc agagccgggc gcccaagctg ctgccctgcc tgcactcttt ctgccagcgc    420

tgcctgcccg cgccccagcg ctacctcatg ctgcccgcgc ccatgc                   466


<210>  2421
<211>  72
<212>  PRT
<213>  Homo sapiens

<400>  2421


Met Asp Gly Gly Ala Glu Arg Gly Glu Arg Gly Arg Glu Ser Ala Gly 
1               5                   10                  15      


Pro Gly Leu Gly Ala Arg Arg Arg Gly Gly Pro Ala Gln Pro Val Gly 
            20                  25                  30          


His Leu Arg Arg Val Pro Pro Glu His Pro Glu Pro Gly Ala Gln Ala 
        35                  40                  45              


Ala Ala Leu Pro Ala Leu Phe Leu Pro Ala Leu Pro Ala Arg Ala Pro 
    50                  55                  60                  


Ala Leu Pro His Ala Ala Arg Ala 
65                  70          

<210>  2422
<211>  5655
<212>  DNA
<213>  Homo sapiens

<400>  2422
atggagggcc cgcgctctgc ggcgtgtcgc gctcggccag caacttcccc gggcgctgtg     60

gacttgaccg cgccgccgcc gccgccgctg ctccgcattc tcaacagccg ggcggcccct    120

gccactcgca cttttgcaga cctctgtcgg agtctcctgc agccggaatc tcgggttctt    180

tgccggctgc agccagttaa ctgctacccg cccgctgcct ccacaaagct ttgtcccagt    240

tggagtcatt cgttgcccag tttgcagcca agaatgtgca gagagacaca tcatagataa    300

cttttttgtg aaggacacta ctgaggttcc cagcagtaca gtagaaaagt caaatcaggt    360

atgtacaagc tgtgaggaca acgcagaagc caatgggttt tgtgtagagt gtgttgaatg    420

gctctgcaag acgtgtatca gagctcatca gagggtaaag ttcacaaaag accacactgt    480

cagacagaaa gaggaagtat ctccagaggc agttggtgtc accagccagc gaccagtgtt    540

ttgtcctttt cataaaaagg agcagctgaa gctgtactgt gagacatgtg acaaactgac    600

atgtcgagac tgtcagttgt tagaacataa agagcataga taccaattta tagaagaagc    660

ttttcagaat cagaaagtga tcatagatac actaatcacc aaactgatgg aaaaaacaaa    720

atacataaaa ttcacaggaa atcagatcca aaacagaatt attgaagtaa atcaaaatca    780

aaagcaggtg gaacaggata ttaaagttgc tatatttaca ctgatggtag aaataaataa    840

aaaaggaaaa gctctactgc atcagttaga gagccttgca aaggaccatc gcatgaaact    900

tatgcaacaa caacaggaag tggctggact ctctaaacaa ttggagcatg tcatgcattt    960

ttctaaatgg gcagtttcca gtggcagcag tacagcatta ctttatagca aacgactgat   1020

tacataccgg ttacggcacc tccttcgtgc aaggtgtgat gcatccccag tgaccaacaa   1080

caccatccaa tttcactgtg atcctagttt ctgggctcaa aatatcatca acttaggttc   1140

tttagtaatc gaggataaag agagccagcc acaaatgcct aagcagaatc ctgtcgtgga   1200

acagaattca cagccaccaa gtggtttatc atcaaaccag ttatccaagt tcccaacaca   1260

gatcagccta gctcaattac ggctccagca tatgcagcaa cagcaaccgc ctccacgttt   1320

gataaacttt cagaatcaca gccccaaacc caatggacca gttcttcctc ctcatcctca   1380

acaactgaga tatccaccaa accagaacat accacgacaa gcaataaagc caaaccccct   1440

acagatggct ttcttggctc aacaagccat aaaacagtgg cagatcagca gtggacaggg   1500

aaccccatca actaccattt tttttttttt tcacagtctg gagtgatagc tactgtagaa   1560

aggaaataga ctttgtatga actctttaag ttgaaaagta aaaaatatat gtggtttgga   1620

tgtgtgcttt aattcagctt tagaaattaa taccactacc cgtgaattat atggcctgac   1680

aatatgaatt aggtgtactg tactgaagaa cagtactcca caaacatggg tggtaacaag   1740

agttccatcc caggaggcca aacggtgcaa cagaagggta ggttagatgc tattaagaag   1800

gcacttaata gtacatcatg taagatggca actgtattaa agaaaaatcc ggaaaacaaa   1860

tgtttgattt ttgtttttgt ttttatcttg tctgtagagg tattttggta tagcaggttt   1920

tcaaggccat tttttataca tttctagatc tagattttca acttcttcca ctgagggaag   1980

tatatacatt tgggtttgct gtgtgtctat gtgaggttta attgtacagg tgatcctttt   2040

acaacaagcc tcattgtttg cagtatagct tttagtggaa ctacccaaaa tataaaatac   2100

agggagaaaa taacttgtta gcaatagatc cccattgttt atatatatag gtcttgttca   2160

taatatgtca attatgtatt gttaaaaagt cctactcact tttcaaatat gtgttacatg   2220

gtaatgtttg tcattgttgt tttaaagttg catttgacat ttgttctcca aagagtgttt   2280

gaacagattt tgataacagt gcatacacct tttgtctttt tttgctccag cattttattt   2340

ttagcacagc agctgtggag cttttgctga taattttatt gttggtatct tagaatactg   2400

ttcgtctgac agtttattct tccatacttg tctcccaagt taaaacagag caaaacagat   2460

aaattatttt gagaatcatc acaaaaggga gttagaactt gtgagactaa aactataatt   2520

tcctaaatgt gactaatgaa ccccaaactg tcactattac attcagtgcc atatttatct   2580

ttcaaaacag tatttgtttc accctaacca tctttggctg aatgaaaggc agttgagaac   2640

catcttttgg tcatacataa tataattata ttaaaagtaa agatcggggc tgggcgcagt   2700

ggctcacacc tgcaatccca ccagcacttt gggaggccaa ggtgggcgga tcacaaagtc   2760

aagagttcga gatcagcctg gccaacattg tgaaaccccg cctctacaaa aaatacaaaa   2820

attagccgga catggtggcg tgcaactgta atcccaacta ctcaggaggc tgagacagga   2880

gaatcacttg aacgcaggag gcagaagttg cagtgagcca agatctcacc attgcactcc   2940

agcctgagtg acagagactc agtctcaaaa acaaaaagta aaggtcttgg gtttctctct   3000

gtaaatagcc tttgtgtaat ggtctttaga ttaatatcct ttgactttat taataagtac   3060

ctgtgtgccc aggtggatct cagctaagtc atccttaaat tctgttcaaa tagaaataaa   3120

ccataaaatg agcctaacta taacccacac tcacttatca agcattcccc caaaagttca   3180

gtgcgattca ggtaaccttg acctaaactt gtacactccg gtgtacatct ttgaccataa   3240

actctgggag atttccctct ggatttggga tcaggagccc agtagggccc cattgctgaa   3300

tgtttatcac acttctggct agggcttatg gatgagcaga ccacgtagga gctaggattt   3360

actcagttcc acctcactga cagcttttct aggtgccaag caactgactt ttcctgtgta   3420

aggaagccca agtacttgac cagtgatata tatggccatg gcaaaagtat aaatggatgg   3480

atgtagacca tattcaacgc agaatacatt ttagatcggt atctggcatt gtaatcattt   3540

tgtcttttga attaacatgc cctgcttgtc ttttctgaat ggaagggtag gaaagtggaa   3600

ggtactaaaa aggaaaatgt agttttagtt tcttttctaa gctaaagaac tggctttact   3660

actgctatat tttactacca catagtagtg tagatgtagt ataacttgct taggaatgct   3720

ttcaaaaagg ttacctccat agtcaaaaaa agggggagta tacagctgat tgttgcattt   3780

atgaaactgc atttcaatat gctatgctgt tactgtgctt agacacttcc ttacgtttga   3840

gttccaagga gagagagtga gaagaggaac tccttttgct gagctctggt ccaaattaat   3900

gtgaatcccc aaagtaaatt gctgcatatg aacaacaggt tttaggttta aattgaagat   3960

acattcattt tatatgtatt tgttgtgaat gagagaaatt gagtgatctg attggccatt   4020

aaaattatgg tgaatgggtc gggcgcagtg gctcacgcct gtaatcccag cactttggga   4080

ggccgaggtg ggtagatacc tgaggtcagg agtttgagac cagcctgacc aacatggtga   4140

aaccccatct ctactaaaaa taccaaaatc accagggtgt ggtggcccat gcctgtaatc   4200

ctagctactc gggaggctga ggcaggagaa tcggcttgaa cccaggaggc agaggttgca   4260

gtgagctgag atcgcaccac tgtagtccag cctgggtgtc agagcaagac tctgtcacaa   4320

aaagaaaaat tatggggaat ggccgggcgc ggtggctcac acctgtaatc ccagcacttt   4380

gggaggccga ggtgggtgga tcacctgaag tcaggagctc aagaccagcc tggccaacat   4440

ggtgaaaccc cacctcaaca gaatatacaa aaaaattagc tgggtgtggt ggcgggtgcc   4500

tgtaatctca gctactttgg gatgctgagg caggagaata gcttgaaccc aggaggtgga   4560

ggttgcagtg agtcgagatt gcaccattgc actccagcct gggcaacaag agcaaaactc   4620

tgtctcaaaa aaaaaaaaaa atggtgacca tgcgttcaac catataattt cttactgaaa   4680

ttgagctcct ccttttgaat aaccatgtac atatttttaa aagtatttta tagccctatg   4740

taaattaata gttgatgtct ttttataaat gtttattgca tattcatctt gaatgtgaat   4800

ttactgttgt aattcacata ctggtgtcat gtttctgagt gagaataatg ctagtcagtc   4860

agatcacaga tttttctcca tgaaggtttt acttattgag agggacatct gaggcagtag   4920

tcttcgtctt taatttttgg gggcagattg gtgctttggt tttaataaaa actaactttg   4980

atggattttt actgtcaata ttttaccaca aggatttttt aatagaaaaa ttactgaatg   5040

ttacttcagc agagttctat ctactttgag tctccattac tactactgtt gttcccctag   5100

ctgtaacatt gatccatata ggggcaagct actagtccat aaatagctgt aataggaaaa   5160

cagtttttta aaattctaac acgtgtattt caccagcctt aaaagattta aaaaaaaatc   5220

tgacaggaag gaaagcgggt ggtaagtatc ttggattatt ctgcctcata ccagccactc   5280

ccaaagtagg aggaccaaag atgccatgaa gacttctagt tgtctggaag ttatttgggg   5340

aaggggggaa agacacagag tggggacctt tggaagtcat tttaaaaatt tagctatgtt   5400

aattccactt gtaaagtttg aaaggttttg attcttgtaa tttctgagaa ttactatgtt   5460

ttaaatttac tattggatat ttaacagatc tttcatgggg ccaacctatt tgcttcctta   5520

attttcaaat taagtcctaa tttgagtcct aaaaaaatct ttccttgtta gttgcaagtt   5580

aaacatttaa taaaattatt ttcccacgtt ttcacatgtg gtatggaata aaggctgttt   5640

taacattccc tgcga                                                    5655


<210>  2423
<211>  279
<212>  PRT
<213>  Homo sapiens

<400>  2423


Met Glu Lys Thr Lys Tyr Ile Lys Phe Thr Gly Asn Gln Ile Gln Asn 
1               5                   10                  15      


Arg Ile Ile Glu Val Asn Gln Asn Gln Lys Gln Val Glu Gln Asp Ile 
            20                  25                  30          


Lys Val Ala Ile Phe Thr Leu Met Val Glu Ile Asn Lys Lys Gly Lys 
        35                  40                  45              


Ala Leu Leu His Gln Leu Glu Ser Leu Ala Lys Asp His Arg Met Lys 
    50                  55                  60                  


Leu Met Gln Gln Gln Gln Glu Val Ala Gly Leu Ser Lys Gln Leu Glu 
65                  70                  75                  80  


His Val Met His Phe Ser Lys Trp Ala Val Ser Ser Gly Ser Ser Thr 
                85                  90                  95      


Ala Leu Leu Tyr Ser Lys Arg Leu Ile Thr Tyr Arg Leu Arg His Leu 
            100                 105                 110         


Leu Arg Ala Arg Cys Asp Ala Ser Pro Val Thr Asn Asn Thr Ile Gln 
        115                 120                 125             


Phe His Cys Asp Pro Ser Phe Trp Ala Gln Asn Ile Ile Asn Leu Gly 
    130                 135                 140                 


Ser Leu Val Ile Glu Asp Lys Glu Ser Gln Pro Gln Met Pro Lys Gln 
145                 150                 155                 160 


Asn Pro Val Val Glu Gln Asn Ser Gln Pro Pro Ser Gly Leu Ser Ser 
                165                 170                 175     


Asn Gln Leu Ser Lys Phe Pro Thr Gln Ile Ser Leu Ala Gln Leu Arg 
            180                 185                 190         


Leu Gln His Met Gln Gln Gln Gln Pro Pro Pro Arg Leu Ile Asn Phe 
        195                 200                 205             


Gln Asn His Ser Pro Lys Pro Asn Gly Pro Val Leu Pro Pro His Pro 
    210                 215                 220                 


Gln Gln Leu Arg Tyr Pro Pro Asn Gln Asn Ile Pro Arg Gln Ala Ile 
225                 230                 235                 240 


Lys Pro Asn Pro Leu Gln Met Ala Phe Leu Ala Gln Gln Ala Ile Lys 
                245                 250                 255     


Gln Trp Gln Ile Ser Ser Gly Gln Gly Thr Pro Ser Thr Thr Ile Phe 
            260                 265                 270         


Phe Phe Phe His Ser Leu Glu 
        275                 

<210>  2424
<211>  1408
<212>  DNA
<213>  Homo sapiens

<400>  2424
cagatggtgt tttttggcta catggttttc agtatcctct ttggcctcct ggctgacaga     60

tatggccgct ggaaggttaa tcataaagac tgaatttttg cccacgaaat accgaggcta    120

tatgttaccc ttgtctcagg tgttctggct tgcgggctcc ctgctcatca ttggcttggc    180

ctctgtgatc atccccacca tcgggtggcg ctggctcatt cgcgtcgcct ccatcccggg    240

catcatcctc atcgtggcct tcaagtttat tcctgaatct gcccggttca atgtctccac    300

tgggaacact cgggctgccc tggccactct ggagcgcgtt gccaagatga accgctcggt    360

catgccggag gggaagctgg tggagcccgt cctggaaaaa agaggaagat ttgcagacct    420

attggatgct aaatatttac ggaccacatt acagatctgg gtcatatggc ttggaatctc    480

ttttgcctac tatggggtta tcctggccag tgctgagctg ctggagcggg acttggtctg    540

tggttcaaag tcagactctg cggtggtggt gactgggggg gactcagggg agagccagag    600

cccctgctac tgccacatgt ttgcaccctc tgactatcgg accatgatca tcagcaccat    660

cggtgaaatt gctttgaatc ctttaaatat actgggcatc aatttcctgg gaagacggct    720

gagcctttct attaccatgg gatgcacggc tttattcttc cttctcctca acatttgcac    780

ttcaagtgcc ggcctgattg gcttcctctt catgctgagg gctctggtag ctgcaaactt    840

caacaccgtc tacatttaca cagctgaggt ctaccccacc acgatgcgcg ctttggggat    900

gggaaccagc ggctccctgt gtcgcattgg tgcaatggtg gcaccattta tatcccaggt    960

tcttatgagt gcatcaatac tgggggccct gtgtctcttc tcatctgtct gtgttgtatg   1020

cgccatttct gcattcactc tccccatcga aaccaaagga cgggccctcc agcaaattaa   1080

atgaagacct gcaaagctat gtctaccaga tgagaaaaat gaattctatc ttcagaactg   1140

cggtgcattt ttttaaaact tggttttact tctgtatgct actcggtaat tagtaaagtg   1200

attttttttt taaaggcata tatgggaatg gggtaggtaa ctgtatattg atctcttcct   1260

tgaggaacaa tatataaagt acttttataa aatataattt aagctttcaa aggggtgtga   1320

gagggagatg gtggggggga agatggcttt tcttcattga aatcaagtct gtaaaccttt   1380

atatgaataa atactaaatt ttaaactt                                      1408


<210>  2425
<211>  340
<212>  PRT
<213>  Homo sapiens

<400>  2425


Met Ala Ala Gly Arg Leu Ile Ile Lys Thr Glu Phe Leu Pro Thr Lys 
1               5                   10                  15      


Tyr Arg Gly Tyr Met Leu Pro Leu Ser Gln Val Phe Trp Leu Ala Gly 
            20                  25                  30          


Ser Leu Leu Ile Ile Gly Leu Ala Ser Val Ile Ile Pro Thr Ile Gly 
        35                  40                  45              


Trp Arg Trp Leu Ile Arg Val Ala Ser Ile Pro Gly Ile Ile Leu Ile 
    50                  55                  60                  


Val Ala Phe Lys Phe Ile Pro Glu Ser Ala Arg Phe Asn Val Ser Thr 
65                  70                  75                  80  


Gly Asn Thr Arg Ala Ala Leu Ala Thr Leu Glu Arg Val Ala Lys Met 
                85                  90                  95      


Asn Arg Ser Val Met Pro Glu Gly Lys Leu Val Glu Pro Val Leu Glu 
            100                 105                 110         


Lys Arg Gly Arg Phe Ala Asp Leu Leu Asp Ala Lys Tyr Leu Arg Thr 
        115                 120                 125             


Thr Leu Gln Ile Trp Val Ile Trp Leu Gly Ile Ser Phe Ala Tyr Tyr 
    130                 135                 140                 


Gly Val Ile Leu Ala Ser Ala Glu Leu Leu Glu Arg Asp Leu Val Cys 
145                 150                 155                 160 


Gly Ser Lys Ser Asp Ser Ala Val Val Val Thr Gly Gly Asp Ser Gly 
                165                 170                 175     


Glu Ser Gln Ser Pro Cys Tyr Cys His Met Phe Ala Pro Ser Asp Tyr 
            180                 185                 190         


Arg Thr Met Ile Ile Ser Thr Ile Gly Glu Ile Ala Leu Asn Pro Leu 
        195                 200                 205             


Asn Ile Leu Gly Ile Asn Phe Leu Gly Arg Arg Leu Ser Leu Ser Ile 
    210                 215                 220                 


Thr Met Gly Cys Thr Ala Leu Phe Phe Leu Leu Leu Asn Ile Cys Thr 
225                 230                 235                 240 


Ser Ser Ala Gly Leu Ile Gly Phe Leu Phe Met Leu Arg Ala Leu Val 
                245                 250                 255     


Ala Ala Asn Phe Asn Thr Val Tyr Ile Tyr Thr Ala Glu Val Tyr Pro 
            260                 265                 270         


Thr Thr Met Arg Ala Leu Gly Met Gly Thr Ser Gly Ser Leu Cys Arg 
        275                 280                 285             


Ile Gly Ala Met Val Ala Pro Phe Ile Ser Gln Val Leu Met Ser Ala 
    290                 295                 300                 


Ser Ile Leu Gly Ala Leu Cys Leu Phe Ser Ser Val Cys Val Val Cys 
305                 310                 315                 320 


Ala Ile Ser Ala Phe Thr Leu Pro Ile Glu Thr Lys Gly Arg Ala Leu 
                325                 330                 335     


Gln Gln Ile Lys 
            340 

<210>  2426
<211>  5006
<212>  DNA
<213>  Homo sapiens

<400>  2426
ttggatttgg tgtttaaagt tatgtctatt tgtaataaca taaagggaga ctgcttctag     60

tggccccaat ttgtgtactg tataaggcag cgcatgaaca gacaatttta aaaattacag    120

tggaaattca caagtacaca tctgaataga gtggagccga agccgtcctc tagcaacaag    180

cgggcggcag aggaccccgt ttccacctgg ggcaggatct gccttgttag gctcccacca    240

acagggagct gaaatcctga acatgaaggg cctcaggggc aagcaagacc aacgtgaaac    300

cctgttcttt aaattaactt ccatccctcc cgtatttcca gcctacttct agtgaaaatg    360

gctaacgggg taaagtaaca tgtaaaacct gcttagagaa ccgttttatc tcgctcccac    420

ttgcagatgg tgttttttgg ctacatggtt ttcagtatcc tctttggcct cctggctgac    480

agatatggcc gctggaaggt aggtggggcc tcacagtagc atttggaatt gtcttttgtg    540

tattcttttg ggggcaacct tatcactgtt tctctttagt aggcatctcc ctcccaatac    600

ccaagataga aaatgcagac atttccctcc ctgatggaac attccaggct tatcttctgg    660

acatttttct cagggtacct gtgcctgcag ctgttcctct gcagtccagg tgtggagtaa    720

aaggagatgc gggtattata gagttctaag aaatctctac ccagaaggat taaaggaagg    780

aaggccgcta agtggctcta tttgaacttt taaaggttgg gacttagaag cagtcatggg    840

ttggttagat gcccccacca cgtccagttt actgtggtgg tgttgagaac agaggtctga    900

tatcagtggg ggcacacatc tgttctccat ttatccatat cttcgcttct aatgagttaa    960

taaggggaat ggaaaaggcc ccttagccct tcagagcagc cctattggga ggttttttcc   1020

tctggttttc atttaaatga ctagtccact gctgcaacag caagctcaga agaagctgtt   1080

ctttcaggac tatgtgtcat gagtgagtgt ccataaagtc tctaaccccc cagagcaccc   1140

aagtaggttg ggagggagca agtctccctt aattttgggg caagaaaact caccctcagg   1200

cacctatctg tttgaaacta gcaggaactg gccacaaatg aaaagagaag tccaaattac   1260

aatcagtagg aaacagatgc aagttttaaa gcctgtgatg gaattttagg acaagaaaaa   1320

gtaaaatgac tagtgctgga tggccaagac cattaagcca aacctgctgc tatgaggcag   1380

aggcagagaa agcagaagtt ctctgcagag ccatttgcct gaatgtcccg tccagggaca   1440

gaaatggaag cccatgctct taaatgagag agtttataaa gaagccaccc aaactgtaga   1500

cctcaaccta aaggaaagga gggccagatt cagaaagact cacccttttg cccccagtga   1560

aacctctgga gttaggggaa cgcagtgggt tcatgcagca agttcaagag gagcctattg   1620

gtaattgtgg gggtaagggg tggtgttgct ctgaaccttg ccagctatgc cagaaacgtc   1680

acattgtgca acttgcggta accttttagg taatttatca gctagtctgg aaactacagg   1740

gaaggtaaga gttgatggat gtacggagtt aaaacatatt agagtgtgga catttgcagg   1800

tataaacata agcagctaca cattttgctc atgttggtat agctttgaaa ctagctacgt   1860

gctcaaagtc acgtgcctac taagattaga catcaagaca taaattatgt cttctgatta   1920

caaacccagg tctgtctttt ctatttgctt gatttctggt gaaatcctct ctgagcataa   1980

acacaaatgg aggaatctca aaggaaaaca ttagtagaat tggctgtatg ttttaaagta   2040

catgaaataa atagcataga ttcttgtaaa tttgaaaaca cgagtatctc aaaaaagcac   2100

aaaaaggcat tttataaaag aaatacaaat tatcaagaaa ctttgaaaaa acattaaagt   2160

acaggagtta tcaaaaacaa aatacatagc aagatataat ttttccttat caaatatgta   2220

aggaaatttt tccttaaaga gtcctgcacc gttgaaatgg acattttcat gacttgcaag   2280

tatatagaca cccttactat atataacacc ctgttggtgt ctcataaaca gagaagataa   2340

aacagtgtta agagttatct tctctgggtt ggacaatcaa tggtgatttc aatttcttaa   2400

ttttcttttt tcttctgtat tgtttactat gaatttatcc ttataattaa agaaaaagca   2460

aataccttaa atgttctcct tgtactcctc ccaacatact gcctcattac gtccccagca   2520

gccctgtgag tagggaggac acgtttttgc cttttgatgt ccaagttcag ggacctgcca   2580

cccatgaggg tgggcacagc atggtagttt taaagaatgg tctgaacttg gtaggtctgg   2640

gcttccagac agtagaatgg catggattgt attgttggat gattgtgaaa gaccagtggg   2700

cttgctacag gttagctcct cagagaagca actatcagga tggaaaccga aaatcgcctt   2760

cagaagttag ggcttcttcc ctccccgcat tgaggcaggt cccattcatg tgttctgctg   2820

ttgcttcaga ttctgctcat ctcgttcctg tggggagcct atttctcctt gctgacctcg   2880

tttgctcctt cgtacatctg gtttgtcttc ctgcggacga tggtgggctg tggtgtgtcc   2940

ggccactcgc aagggttaat cataaagact gaatttttgc ccacgaaata ccgaggctat   3000

atgttaccct tgtctcaggt gttctggctt gcgggctccc tgctcatcat tggcttggcc   3060

tctgtgatca tccccaccat cgggtggcgc tggctcattc gcgtcgcctc catcccgggc   3120

atcatcctca tcgtggcctt caagtttatt cctgaatctg cccggttcaa tgtctccact   3180

gggaacactc gggctgccct ggccactctg gagcgcgttg ccaagatgaa ccgctcggtc   3240

atgccggagg ggaagctggt ggagcccgtc ctggaaaaaa gaggaagatt tgcagaccta   3300

ttggatgcta aatatttacg gaccacatta cagatctggg tcatatggct tggaatctct   3360

tttgcctact atggggttat cctggccagt gctgagctgc tggagcggga cttggtctgt   3420

ggttcaaagt cagactctgc ggtggtggtg actggggggg actcagggga gagccagagc   3480

ccctgctact gccacatgtt tgcaccctct gactatcgga ccatgatcat cagcaccatc   3540

ggtgaaattg ctttgaatcc tttaaatata ctgggcatca atttcctggg aagacggctg   3600

agcctttcta ttaccatggg atgcacggct ttattcttcc ttctcctcaa catttgcact   3660

tcaagtgccg gcctgattgg cttcctcttc atgctgaggg ctctggtagc tgcaaacttc   3720

aacaccgtct acatttacac agctgaggtc taccccacca cgatgcgcgc tttggggatg   3780

ggaaccagcg gctccctgtg tcgcattggt gcaatggtgg caccatttat atcccagaga   3840

gctttgctgt tggttaacca cttcatactt tactgtcgtt gtgagattaa tggagaacta   3900

tcaagaacac agaccaagag aaactaaagt atgagatgga gtatctgaat taccagtatc   3960

tgcgtgaaaa gatccaggcc aaagcatgtg tacagatgga cagaaaccca gttactgtgg   4020

aaaaattgac accaaagagt tttggtgtca cacaactcca taaccggaga caagacacat   4080

tagcaatcct ttcagagact ctgagataac acctcttcca aaaaaaactt tcacctgttt   4140

catgctgtca ggactgaaga gataatggat atttggcaga cagaggatat agcatgaagt   4200

gagagttaga agttaagcaa gctgaaatgg tatgagaaag ggggtgggga aacgggcaga   4260

tcccccatct tttccatata tcaaaacttg gctctggaga tgcctgacag gtggatgcca   4320

agagaggtct tacctggcca atgcgtgtta ataccagttc ctgttcttgg actaatcaca   4380

caaaatgact acaccagatt ggctcagata aatcaatttg tcaggaaggt acaacctgta   4440

gaatggctgc aaaggaccat cttagtgaag tgaatctgta ttttctcttt cacataaaga   4500

acagtttaga ggtaactgga gcataataaa ttgagtaatt ctcttgtgac ttgcaggttc   4560

ttatgagtgc atcaatactg ggggccctgt gtctcttctc atctgtctgt gttgtatgcg   4620

ccatttctgc attcactctc cccatcgaaa ccaaaggacg ggccctccag caaattaaat   4680

gaagacctgc aaagctatgt ctaccagatg agaaaaatga attctatctt cagaactgcg   4740

gtgcattttt ttaaaacttg gttttacttc tgtatgctac tcggtaatta gtaaagtgat   4800

ttttttttta aaggcatata tgggaatggg gtaggtaact gtatattgat ctcttccttg   4860

aggaacaata tataaagtac ttttataaaa tataatttaa gctttcaaag gggtgtgaga   4920

gggagatggt gggggggaag atggcttttc ttcattgaaa tcaagtctgt aaacctttat   4980

atgaataaat actaaatttt aaactt                                        5006


<210>  2427
<211>  335
<212>  PRT
<213>  Homo sapiens

<400>  2427


Met Val Gly Cys Gly Val Ser Gly His Ser Gln Gly Leu Ile Ile Lys 
1               5                   10                  15      


Thr Glu Phe Leu Pro Thr Lys Tyr Arg Gly Tyr Met Leu Pro Leu Ser 
            20                  25                  30          


Gln Val Phe Trp Leu Ala Gly Ser Leu Leu Ile Ile Gly Leu Ala Ser 
        35                  40                  45              


Val Ile Ile Pro Thr Ile Gly Trp Arg Trp Leu Ile Arg Val Ala Ser 
    50                  55                  60                  


Ile Pro Gly Ile Ile Leu Ile Val Ala Phe Lys Phe Ile Pro Glu Ser 
65                  70                  75                  80  


Ala Arg Phe Asn Val Ser Thr Gly Asn Thr Arg Ala Ala Leu Ala Thr 
                85                  90                  95      


Leu Glu Arg Val Ala Lys Met Asn Arg Ser Val Met Pro Glu Gly Lys 
            100                 105                 110         


Leu Val Glu Pro Val Leu Glu Lys Arg Gly Arg Phe Ala Asp Leu Leu 
        115                 120                 125             


Asp Ala Lys Tyr Leu Arg Thr Thr Leu Gln Ile Trp Val Ile Trp Leu 
    130                 135                 140                 


Gly Ile Ser Phe Ala Tyr Tyr Gly Val Ile Leu Ala Ser Ala Glu Leu 
145                 150                 155                 160 


Leu Glu Arg Asp Leu Val Cys Gly Ser Lys Ser Asp Ser Ala Val Val 
                165                 170                 175     


Val Thr Gly Gly Asp Ser Gly Glu Ser Gln Ser Pro Cys Tyr Cys His 
            180                 185                 190         


Met Phe Ala Pro Ser Asp Tyr Arg Thr Met Ile Ile Ser Thr Ile Gly 
        195                 200                 205             


Glu Ile Ala Leu Asn Pro Leu Asn Ile Leu Gly Ile Asn Phe Leu Gly 
    210                 215                 220                 


Arg Arg Leu Ser Leu Ser Ile Thr Met Gly Cys Thr Ala Leu Phe Phe 
225                 230                 235                 240 


Leu Leu Leu Asn Ile Cys Thr Ser Ser Ala Gly Leu Ile Gly Phe Leu 
                245                 250                 255     


Phe Met Leu Arg Ala Leu Val Ala Ala Asn Phe Asn Thr Val Tyr Ile 
            260                 265                 270         


Tyr Thr Ala Glu Val Tyr Pro Thr Thr Met Arg Ala Leu Gly Met Gly 
        275                 280                 285             


Thr Ser Gly Ser Leu Cys Arg Ile Gly Ala Met Val Ala Pro Phe Ile 
    290                 295                 300                 


Ser Gln Arg Ala Leu Leu Leu Val Asn His Phe Ile Leu Tyr Cys Arg 
305                 310                 315                 320 


Cys Glu Ile Asn Gly Glu Leu Ser Arg Thr Gln Thr Lys Arg Asn 
                325                 330                 335 

<210>  2428
<211>  654
<212>  DNA
<213>  Homo sapiens

<400>  2428
tccatgctgc cttttataat ttctctccgc ttcctgtttt ctagtgccgg cctgattggc     60

ttcctcttca tgctgagggc tctggtagct gcaaacttca acaccgtcta catttacaca    120

gctgaggtct accccaccac gatgcgcgct ttggggatgg gaaccagcgg ctccctgtgt    180

cgcattggtg caatggtggc accatttata tcccaggttc ttatgagtgc atcaatactg    240

ggggccctgt gtctcttctc atctgtctgt gttgtatgcg ccatttctgc attcactctc    300

cccatcgaaa ccaaaggacg ggccctccag caaattaaat gaagacctgc aaagctatgt    360

ctaccagatg agaaaaatga attctatctt cagaactgcg gtgcattttt ttaaaacttg    420

gttttacttc tgtatgctac tcggtaatta gtaaagtgat ttttttttta aaggcatata    480

tgggaatggg gtaggtaact gtatattgat ctcttccttg aggaacaata tataaagtac    540

ttttataaaa tataatttaa gctttcaaag gggtgtgaga gggagatggt gggggggaag    600

atggcttttc ttcattgaaa tcaagtctgt aaacctttat atgaataaat acta          654


<210>  2429
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  2429


Met Leu Pro Phe Ile Ile Ser Leu Arg Phe Leu Phe Ser Ser Ala Gly 
1               5                   10                  15      


Leu Ile Gly Phe Leu Phe Met Leu Arg Ala Leu Val Ala Ala Asn Phe 
            20                  25                  30          


Asn Thr Val Tyr Ile Tyr Thr Ala Glu Val Tyr Pro Thr Thr Met Arg 
        35                  40                  45              


Ala Leu Gly Met Gly Thr Ser Gly Ser Leu Cys Arg Ile Gly Ala Met 
    50                  55                  60                  


Val Ala Pro Phe Ile Ser Gln Val Leu Met Ser Ala Ser Ile Leu Gly 
65                  70                  75                  80  


Ala Leu Cys Leu Phe Ser Ser Val Cys Val Val Cys Ala Ile Ser Ala 
                85                  90                  95      


Phe Thr Leu Pro Ile Glu Thr Lys Gly Arg Ala Leu Gln Gln Ile Lys 
            100                 105                 110         

<210>  2430
<211>  11273
<212>  DNA
<213>  Homo sapiens

<400>  2430
tcttctgcgc tctccgcctt ttctctctag actggatctc tcctcccccc cgcgcccccc     60

tccccgcatc tcccactcgc tggctctctc tccagctgcc tcctctccag gtctctcctg    120

gctgcgcgcg ctcctctccc cgcttctccc cctcccgcag cctcgccgcc ttggtgcctt    180

cctgcccggc tcggccggcg ctcgtccccg gccccggccc cgccagcccg ggtctccgcg    240

ctcggagcag ctcagccctg cagtggctcg ggacccgatg ctatgagagg gaagcgagcc    300

gggcgcccag accttcagga ggcgtcggat gcgcggcggg tcttgggacc gggctctctc    360

tccggctcgc cttgccctcg ggtgattatt tggctccgct catagccctg ccttcctcgg    420

aggagccatc ggtgtcgcgt gcgtgtggag tatctgcaga catgactgcg tggaggagat    480

tccagtcgct gctcctgctt ctcgggctgc tggtgctgtg cgcgaggctc ctcactgcag    540

cgaagggtca gaactgtgga ggcttagtcc agggtcccaa tggcactatt gagagcccag    600

ggtttcctca cgggtatccg aactatgcca actgcacctg gatcatcatc acgggcgagc    660

gcaataggat acagttgtcc ttccatacct ttgctcttga agaagatttt gatattttat    720

cagtttacga tggacagcct caacaaggga atttaaaagt gagattatcg ggatttcagc    780

tgccctcctc tatagtgagt acaggatcta tcctcactct gtggttcacg acagacttcg    840

ctgtgagtgc ccaaggtttc aaagcattat atgaagtttt acctagccac acttgtggaa    900

atcctggaga aatcctgaaa ggagttctgc atggaacgag attcaacata ggagacaaaa    960

tccggtacag ctgcctccct ggctacatct tggaaggcca cgccatcctg acctgcatcg   1020

tcagcccagg aaatggtgca tcgtgggact tcccagctcc cttttgcaga gctgagggag   1080

cctgcggagg aaccttacgc gggaccagca gctccatctc cagcccgcac ttcccttcag   1140

agtacgagaa caacgcggac tgcacctgga ccattctggc tgagcccggg gacaccattg   1200

cgctggtctt cactgacttt cagctagaag aaggatatga tttcttagag atcagtggca   1260

cggaagctcc atccatatgg ctaactggca tgaacctccc ctctccagtt atcagtagca   1320

agaattggct acgactccat ttcacctctg acagcaacca ccgacgcaaa ggatttaacg   1380

ctcagttcca agtgagccaa ggaggtgttg cattggtctc tgacatgtgt ccagatcctg   1440

ggattccaga aaatggtaga agagcaggtt ccgaggctta gggttggtgc aaatgtacag   1500

ttttcatgtg aggacaatta cgtgctccag ggatctaaaa gcatcacctg tcagagagtt   1560

acagagacgc tcgctgcttg gagtgaccac aggcccatct gccgagcgag aacatgtgga   1620

tccaatctgc gtgggcccag cggcgtcatt acctccccta attatccggt tcagtatgaa   1680

gataatgcac actgtgtgtg ggtcatcacc accaccgacc cggacaaggt catcaagctt   1740

gcctttgaag agtttgagct ggagcgaggc tatgacaccc tgacggttgg tgatgctggg   1800

aaggtgggag acaccagatc ggtcttgtac gtgctcacgg gatccagtgt tcctgacctc   1860

attgtgagca tgagcaacca gatgtggcta catctgcagt cggatgatag cattggctca   1920

cctgggttta aagctgttta ccaagaaatt gaaaagggag ggtgtgggga tcctggaatc   1980

cccgcctatg ggaagcggac gggcagcagt ttcctccatg gagatacact cacctttgaa   2040

tgcccggcgg cctttgagct ggtgggggga gagagttatc acctgtcagc agaacaatca   2100

gtggtctggc aacaagccca gctgtgtatt ttcatgtttc ttcaacttta cggcatcatc   2160

tgggattatt ctgtcaccaa attatccaga ggaatatggg aacaacatga actgtgtctg   2220

gttgattatc tcggagccag gaagtcgaat tcacctaatc tttaatgatt ttgatgttga   2280

gcctcagttt gactttctcg cggtcaagga tgatggcatt tctgacataa ctgtcctggg   2340

tactttttct ggcaatgaag tgccttccca gctggccagc agtgggcata tagttcgctt   2400

ggaatttcag tctgaccatt ccactactgg cagagggttc aacatcactt acaccacatt   2460

tggtcagaat gagtgccatg atcctggcat tcctataaac ggacgacgtt ttggtgacag   2520

gtttctactc gggagctcgg tttctttcca ctgtgatgat ggctttgtca agacccaggg   2580

atccgagtcc attacctgca tactgcaaga cgggaacgtg gtctggagct ccaccgtgcc   2640

ccgctgtgaa gctccatgtg gtggacatct gacagcgtcc agcggagtca ttttgcctcc   2700

tggatggcca ggatattata aggattcttt acattgtgaa tggataattg aagcaaaacc   2760

aggccactct atcaaaataa cttttgacag atttcagaca gaggtcaatt atgacacctt   2820

ggaggtcaga gatgggccag ccagttcgtc cccactgatc ggcgagtacc acggcaccca   2880

ggcaccccag ttcctcatca gcaccgggaa cttcatgtac ctgctgttca ccactgacaa   2940

cagccgctcc agcatcggct tcctcatcca ctatgagagt gtgacgcttg agtcggattc   3000

ctgcctggac ccgggcatcc ctgtgaacgg ccatcgccac ggtggagact ttggcatcag   3060

gtccacagtg actttcagct gtgacccggg gtacacacta agtgacgacg agcccctcgt   3120

ctgtgagagg aaccaccagt ggaaccacgc cttgcccagc tgcgacgctc tatgtggagg   3180

ctacatccaa gggaagagtg gaacagtcct ttctcctggg tttccagatt tttatccaaa   3240

ctctctaaac tgcacgtgga ccattgaagt gtctcatggg aaaggagttc aaatgatctt   3300

tcacaccttt catcttgaga gttcccacga ctatttactg atcacagagg atggaagttt   3360

ttccgagccc gttgccaggc tcaccgggtc ggtgttgcct catacgatca aggcaggcct   3420

gtttggaaac ttcactgccc agcttcggtt tatatcagac ttctcaattt cgtacgaggg   3480

cttcaatatc acattttcag aatatgacct ggagccatgt gatgatcctg gagtccctgc   3540

cttcagccga agaattggtt ttcactttgg tgtgggagac tctctgacgt tttcctgctt   3600

cctgggatat cgtttagaag gtgccaccaa gcttacctgc ctgggtgggg gccgccgtgt   3660

gtggagtgca cctctgccaa ggtgtgtggc cgaatgtgga gcaagtgtca aaggaaatga   3720

aggaacatta ctgtctccaa attttccatc caattatgat aataaccatg agtgtatcta   3780

taaaatagaa acagaagccg gcaagggcat ccaccttaga acacgaagct tccagctgtt   3840

tgaaggagat actctaaagg tatatgatgg aaaagacagt tcctcacgtc cactgggcac   3900

gttcactaaa aatgaacttc tggggctgat cctaaacagc acatccaatc acctgtggct   3960

agagttcaac accaatggat ctgacaccga ccaaggtttt caactcacct ataccagttt   4020

tgatctggta aaatgtgagg atccgggcat ccctaactac ggctatagga tccgtgatga   4080

aggccacttt accgacactg tagttctgta cagttgcaac ccggggtacg ccatgcatgg   4140

cagcaacacc ctgacctgtt tgagtggaga caggagagtg tgggacaaac cactaccttc   4200

gtgcatagcg gaatgtggtg gtcagatcca tgcagccaca tcaggacgaa tattgtcccc   4260

tggctatcca gctccgtatg acaacaacct ccactgcacc tggattatag aggcagaccc   4320

aggaaagacc attagcctcc atttcattgt tttcgacacg gagatggctc acgacatcct   4380

caaggtctgg gacgggccgg tggacagtga catcctgctg aaggagtgga gtggctccgc   4440

ccttccggag gacatccaca gcaccttcaa ctcactcacc ctgcagttcg acagcgactt   4500

cttcatcagc aagtctggct tctccatcca gttctccacc tcaattgcag ccacctgtaa   4560

cgatccaggt atgccccaaa atggcacccg ctatggagac agcagagagg ctggagacac   4620

cgtcacattc cagtgtgacc ctggctatca gctccaagga caagccaaaa tcacctgtgt   4680

gcagctgaat aaccggttct tttggcaacc agaccctcct acatgcatag ctgcttgtgg   4740

agggaatctg acgggcccag caggtgttat tttgtcaccc aactacccac agccgtatcc   4800

tcctgggaag gaatgtgact ggagagtaaa agtgaacccg gactttgtca tcgccttgat   4860

attcaaaagt ttcaacatgg agcccagcta tgacttccta cacatctatg aaggggaaga   4920

ttccaacagc cccctcattg ggagttacca gggctctcag gccccagaaa gaatagagag   4980

tagcggaaac agcctgtttc tggcatttcg gagtgatgcc tccgtgggcc tttcagggtt   5040

cgccattgaa tttaaagaga aaccacggga agcttgtttt gacccaggaa atataatgaa   5100

tgggacaaga gttggaacag acttcaagct tggctccacc atcacctacc agtgtgactc   5160

tggctataag attcttgacc cctcatccat cacctgtgtg attggggctg atgggaaacc   5220

ctcctgggac caagtgctgc cctcctgcaa tgctccctgt ggaggccagt acacgggatc   5280

agaaggggta gttttatcac caaactaccc ccataattac acagctggtc aaatatgcct   5340

ctattccatc acggtaccaa aggaattcgt ggtctttgga cagtttgcct atttccagac   5400

agccctgaat gatttggcag aattatttga tggaacccat gcacaggcca gacttctcag   5460

ctcactctcg gggtctcact caggggaaac attgcccttg gctacgtcaa atcaaattct   5520

gctccgattc agtgcaaaga gcggtgcctc tgcccgcggc ttccacttcg tgtatcaagc   5580

tgttcctcgt accagtgaca cccaatgcag ctctgtcccc gagcccagat acggaaggag   5640

aattggttct gagttttctg ccggctccat cgtccgattc gagtgcaacc cgggatacct   5700

gcttcagggt tccacggcgc tccactgcca gtccgtgccc aacgccttgg cacagtggaa   5760

cgacacgatc cccagctgtg tggtaccctg cagtggcaat ttcactcaac gaagaggtac   5820

aatcctgtcc cccggctacc ctgagccata cggaaacaac ttgaactgta tatggaagat   5880

catagttacg gagggctcgg gaattcagat ccaagtgatc agttttgcca cggagcagaa   5940

ctgggactcc cttgagatcc acgatggtgg ggatgtgacc gcacccagac tgggaagctt   6000

ctcaggcacc acagtaccgg cactgctgaa cagtacttcc aaccaactct acctgcattt   6060

ccagtctgac attagtgtgg cagctgctgg tttccacctg gaatacaaaa ctgtaggtct   6120

tgctgcatgc caagaaccag ccctccccag caacagcatc aaaatcggag atcggtacat   6180

ggtgaacgac gtgctctcct tccagtgcga gcccgggtac accctgcagg gccgttccca   6240

catttcctgt atgccaggga ccgttcgccg ttggaactat ccgtctcccc tgtgcattgc   6300

aacctgtgga gggacgctga gcaccttggg tggtgtgatc ctgagccccg gcttcccagg   6360

ttcttacccc aacaacttag actgcacctg gaggatctca ttacccatcg gctatggtgc   6420

acatattcag tttctgaatt tttctaccga agctaatcat gacttccttg aaattcaaaa   6480

tggaccttac cacaccagcc ccatgattgg acaatttagc ggcacggatc tccccgcggc   6540

cctgctgagc acaacgcatg aaaccctcat ccacttttat agtgaccatt cgcaaaaccg   6600

gcaaggattt aaacttgctt accaagccta tgaattacag aactgtccag atccaccccc   6660

atttcagaat gggtacatga tcaactcgga ttacagcgtg gggcaatcag tatctttcga   6720

gtgttatcct gggtacattc taataggcca tcctgtcctc acttgtcagc atgggatcaa   6780

cagaaactgg aactaccctt ttccaagatg tgatgcccct tgtgggtaca acgtaacttc   6840

tcagaacggc accatctact cccctggctt tcctgatgag tatccgatcc tgaaggactg   6900

catttggctc atcacggtgc ctccagggca cggagtttac atcaacttca ccctgttaca   6960

gacggaagct gtcaacgatt acattgctgt ttgggacggt cccgatcaga actcacccca   7020

gctgggagtt ttcagtggca acacagccct cgaaacggcg tatagctcca ccaaccaagt   7080

cctgctcaag ttccacagcg acttttcaaa tggaggcttc tttgtcctca atttccacgc   7140

atttcagctc aagaaatgtc aacctccccc agcggttcca caggcagaaa tgcttactga   7200

ggatgatgat ttcgaaatag gagattttgt gaagtaccag tgccaccccg ggtacacctt   7260

ggtggggacc gacattctga cttgcaagct cagttcccag ttgcagtttg agggttctct   7320

cccaacatgt gaagcacaat gcccagcaaa tgaagtccgg actggatcat cgggagtcat   7380

tctcagtcca gggtatccgg gtaattattt taactcccag acttgctctt ggagtattaa   7440

agtggaacca aactacaaca ttaccatctt tgtggacaca tttcaaagtg aaaagcagtt   7500

tgatgcactg gaagtgtttg atggttcttc tgggcaaagt cctctgctag tagtcttaag   7560

tgggaatcat actgaacaat caaattttac aagcaggagt aatcagttat atctccgctg   7620

gtccactgac catgccacca gtaagaaagg attcaagatt cgctatgcag caccttactg   7680

cagtttgacc caccccctga agaatggggg tattctaaac aggactgcag gagcggttgg   7740

aagcaaagtg cattattttt gcaagcctgg ataccgaatg gtcggccaca gcaatgcaac   7800

ctgtagacga aacccacttg gcatgtacca gtgggactcc ctcacgccac tctgccaggc   7860

tgtgtcctgt ggaatcccag aatccccagg aaacggttca tttaccggga acgagttcac   7920

tttggacagt aaagtggtct atgaatgtca tgagggcttc aagcttgaat ccagccagca   7980

agcaacagcc gtgtgtcaag aagatgggtt gtggagtaac aaggggaagc cgcccacgtg   8040

taagccggtc gcttgcccca gcattgaagc tcagctctca gaacatgtca tctggaggct   8100

ggtttcagga tccttgaatg agtacggtgc tcaagtattg ctgagctgca gtcctggtta   8160

ctacttagaa ggctggaggc tcctgcggtg ccaggccaat gggacgtgga acataggaga   8220

tgagaggcca agctgtcgag ctggccactg cggttcccca gacccgattg tgaacggtca   8280

cattagtgga gatggcttca gttacagaga cacggtggtt taccagtgca atcctggttt   8340

ccggcttgtg ggaacttccg tgaggatatg cctgcaagac cacaagtggt ctggacaaac   8400

gcctgtctgt gtccccatca catgtggtca ccctggaaac cctgcccacg gattcactaa   8460

tggcagtgag ttcaacctga atgatgtcgt gaatttcacc tgcaacacgg gctatttgct   8520

gcagggcgtg tctcgagccc agtgtcggag caacggccag tggagtagcc ctctgcccac   8580

gtgtcgagtg gtgaactgtt ctgatccagg ctttgtggaa aatgccattc gtcacgggca   8640

acagaacttc cctgagagtt ttgagtatgg aatgagtatc ctgtaccatt gcaagaaggg   8700

attttacttg ctgggatctt cagccttgac ctgtatggca aatggcttat gggaccgatc   8760

cctgcccaag tgtttggcta tatcgtgtgg acacccaggg gtccctgcca acgccgtcct   8820

cactggagag ctgtttacct atggcgccgt cgtgcactac tcctgcagag ggagcgagag   8880

cctcataggc aacgacacga gagtgtgcca ggaagacagt cactggagcg gggcactgcc   8940

ccactgcaca ggaaataatc ctggattctg tggtgatccg gggaccccag cacatgggtc   9000

tcggcttggt gatgacttta agacaaagag tcttctccgc ttctcctgtg aaatggggca   9060

ccagctgagg ggctcccctg aacgcacgtg tttgctcaat gggtcatggt caggactgca   9120

gccggtgtgt gaggccgtgc tgtgtcctca gccgccgccg gtgcagaatg gaacagtgga   9180

gggaagtgat ttccgctggg gctccagcat aagttacagc tgcatggacg gttaccagct   9240

ctctcactcc gccatcctct cctgtgaagg tcgcggggtg tggaaaggag agatccccca   9300

gtgtctccct gtgttctgcg gagaccctgg catccccgca gaagggcgac ttagtgggaa   9360

aagtttcacc tataagtccg aagtcttctt ccagtgcaaa tctccattta tactcgtggg   9420

atcctccaga agagtctgcc aagctgacgg cacgtggagc ggcatacaac ccacctgcat   9480

tgatcctgct cataacacct gcccagaccc tggtacgcca cactttggaa tacagaatag   9540

ctccagaggc tatgaggttg gaagcacggt ttttttcagg tgcagaaaag gctaccatat   9600

tcaaggttcc acgactcgca cctgccttgc caatttaaca tggagtggga tacagaccga   9660

atgtatacct catgcctgca gacagccaga aaccccggca cacgcggatg tgagagccat   9720

cgatcttcct actttcggct acaccttagt gtacacctgc catccaggct ttttcctcgc   9780

agggggatct gagcacagaa catgtaaagc agacatgaaa tggacaggaa agtcgcctgt   9840

gtgtaaaagt aaaggagtga gagaagttaa tgaaacagtt actaaaactc cagttccttc   9900

agatgtcttt ttcgtcaatt cactgtggaa ggggtattat gaatatttag ggaaaagaca   9960

acccgccact ctaactgttg actggttcaa tgcaacaagc agtaaggtga atgccacctt  10020

cagcgaagcc tcgccagtgg agctgaagtt gacaggcatt tacaagaagg aggaggccca  10080

cttactcctg aaagcttttc aaattaaagg ccaggcagat atttttgtaa gcaagttcga  10140

aaatgacaac tggggactag atggttatgt gtcatctgga cttgaaagag gaggatttac  10200

ttttcaaggt gacattcatg gaaaagactt tggaaaattt aagctagaaa ggcaagatcc  10260

tttaaaccca gatcaagact cttccagtca ttaccacggc accagcagtg gctctgtggc  10320

ggctgccatt ctggttcctt tctttgctct aattttatca gggtttgcat tttacctcta  10380

caaacacaga acgagaccaa aagttcaata caatggctat gctgggcatg aaaacagcaa  10440

tggacaagca tcgtttgaaa accccatgta tgatacaaac ttaaaaccca cagaagccaa  10500

ggctgtgagg tttgacacaa ctctgaacac agtctgtaca gtggtatagc cctcagtgcc  10560

ccaacaggac tgattcatag ccatacctct gatggacaag cagtgattcc tttggtgcca  10620

tataccactc tcccttccac tctggcttta ctgcagcgat cttcaacctt gtctactggc  10680

ataagtgcag cggggatctc tactcaaatg tgtcagggtc ttctacggat caaactacac  10740

atgcgttttc attccaaaag tgggttctaa atgcctggct gcatctgtat gaaatcaagg  10800

cacactccag gaagactgcc acgtcgcgcc aacacgtcat actcaatgcc tcagactttc  10860

atatttctgt gttgctgaga tgcctttcaa tgcaatcgtc tgggctcgtg gatatgtccc  10920

tcaggtgcgg tgacagaatg gtggcaccac gatatgtgtt ctcttgtgtt gtttttcctt  10980

tttaaacccc catgaacacg aatactctga aaaaaataaa aagctttctg gaagaagaca  11040

cctttctgat agaggctcac acctacaaat gcttcactct gtccttccga gacctgacaa  11100

gctttgagga cctcacagct cccctgtgtg ttcatctcta gggatgtttg caatttccca  11160

gtcagctgtt ctgtcgcaga atgtttaatg cacaattttt tgcactagtg tgttatgaat  11220

gactaagatt ctgataaaaa aaataaatta tttacacagg gtttatacac act         11273


<210>  2431
<211>  2881
<212>  PRT
<213>  Homo sapiens

<400>  2431


Met Ile Ala Leu Ala His Leu Gly Leu Lys Leu Phe Thr Lys Lys Leu 
1               5                   10                  15      


Lys Arg Glu Gly Val Gly Ile Leu Glu Ser Pro Pro Met Gly Ser Gly 
            20                  25                  30          


Arg Ala Ala Val Ser Ser Met Glu Ile His Ser Pro Leu Asn Ala Arg 
        35                  40                  45              


Arg Pro Leu Ser Trp Trp Gly Glu Arg Val Ile Thr Cys Gln Gln Asn 
    50                  55                  60                  


Asn Gln Trp Ser Gly Asn Lys Pro Ser Cys Val Phe Ser Cys Phe Phe 
65                  70                  75                  80  


Asn Phe Thr Ala Ser Ser Gly Ile Ile Leu Ser Pro Asn Tyr Pro Glu 
                85                  90                  95      


Glu Tyr Gly Asn Asn Met Asn Cys Val Trp Leu Ile Ile Ser Glu Pro 
            100                 105                 110         


Gly Ser Arg Ile His Leu Ile Phe Asn Asp Phe Asp Val Glu Pro Gln 
        115                 120                 125             


Phe Asp Phe Leu Ala Val Lys Asp Asp Gly Ile Ser Asp Ile Thr Val 
    130                 135                 140                 


Leu Gly Thr Phe Ser Gly Asn Glu Val Pro Ser Gln Leu Ala Ser Ser 
145                 150                 155                 160 


Gly His Ile Val Arg Leu Glu Phe Gln Ser Asp His Ser Thr Thr Gly 
                165                 170                 175     


Arg Gly Phe Asn Ile Thr Tyr Thr Thr Phe Gly Gln Asn Glu Cys His 
            180                 185                 190         


Asp Pro Gly Ile Pro Ile Asn Gly Arg Arg Phe Gly Asp Arg Phe Leu 
        195                 200                 205             


Leu Gly Ser Ser Val Ser Phe His Cys Asp Asp Gly Phe Val Lys Thr 
    210                 215                 220                 


Gln Gly Ser Glu Ser Ile Thr Cys Ile Leu Gln Asp Gly Asn Val Val 
225                 230                 235                 240 


Trp Ser Ser Thr Val Pro Arg Cys Glu Ala Pro Cys Gly Gly His Leu 
                245                 250                 255     


Thr Ala Ser Ser Gly Val Ile Leu Pro Pro Gly Trp Pro Gly Tyr Tyr 
            260                 265                 270         


Lys Asp Ser Leu His Cys Glu Trp Ile Ile Glu Ala Lys Pro Gly His 
        275                 280                 285             


Ser Ile Lys Ile Thr Phe Asp Arg Phe Gln Thr Glu Val Asn Tyr Asp 
    290                 295                 300                 


Thr Leu Glu Val Arg Asp Gly Pro Ala Ser Ser Ser Pro Leu Ile Gly 
305                 310                 315                 320 


Glu Tyr His Gly Thr Gln Ala Pro Gln Phe Leu Ile Ser Thr Gly Asn 
                325                 330                 335     


Phe Met Tyr Leu Leu Phe Thr Thr Asp Asn Ser Arg Ser Ser Ile Gly 
            340                 345                 350         


Phe Leu Ile His Tyr Glu Ser Val Thr Leu Glu Ser Asp Ser Cys Leu 
        355                 360                 365             


Asp Pro Gly Ile Pro Val Asn Gly His Arg His Gly Gly Asp Phe Gly 
    370                 375                 380                 


Ile Arg Ser Thr Val Thr Phe Ser Cys Asp Pro Gly Tyr Thr Leu Ser 
385                 390                 395                 400 


Asp Asp Glu Pro Leu Val Cys Glu Arg Asn His Gln Trp Asn His Ala 
                405                 410                 415     


Leu Pro Ser Cys Asp Ala Leu Cys Gly Gly Tyr Ile Gln Gly Lys Ser 
            420                 425                 430         


Gly Thr Val Leu Ser Pro Gly Phe Pro Asp Phe Tyr Pro Asn Ser Leu 
        435                 440                 445             


Asn Cys Thr Trp Thr Ile Glu Val Ser His Gly Lys Gly Val Gln Met 
    450                 455                 460                 


Ile Phe His Thr Phe His Leu Glu Ser Ser His Asp Tyr Leu Leu Ile 
465                 470                 475                 480 


Thr Glu Asp Gly Ser Phe Ser Glu Pro Val Ala Arg Leu Thr Gly Ser 
                485                 490                 495     


Val Leu Pro His Thr Ile Lys Ala Gly Leu Phe Gly Asn Phe Thr Ala 
            500                 505                 510         


Gln Leu Arg Phe Ile Ser Asp Phe Ser Ile Ser Tyr Glu Gly Phe Asn 
        515                 520                 525             


Ile Thr Phe Ser Glu Tyr Asp Leu Glu Pro Cys Asp Asp Pro Gly Val 
    530                 535                 540                 


Pro Ala Phe Ser Arg Arg Ile Gly Phe His Phe Gly Val Gly Asp Ser 
545                 550                 555                 560 


Leu Thr Phe Ser Cys Phe Leu Gly Tyr Arg Leu Glu Gly Ala Thr Lys 
                565                 570                 575     


Leu Thr Cys Leu Gly Gly Gly Arg Arg Val Trp Ser Ala Pro Leu Pro 
            580                 585                 590         


Arg Cys Val Ala Glu Cys Gly Ala Ser Val Lys Gly Asn Glu Gly Thr 
        595                 600                 605             


Leu Leu Ser Pro Asn Phe Pro Ser Asn Tyr Asp Asn Asn His Glu Cys 
    610                 615                 620                 


Ile Tyr Lys Ile Glu Thr Glu Ala Gly Lys Gly Ile His Leu Arg Thr 
625                 630                 635                 640 


Arg Ser Phe Gln Leu Phe Glu Gly Asp Thr Leu Lys Val Tyr Asp Gly 
                645                 650                 655     


Lys Asp Ser Ser Ser Arg Pro Leu Gly Thr Phe Thr Lys Asn Glu Leu 
            660                 665                 670         


Leu Gly Leu Ile Leu Asn Ser Thr Ser Asn His Leu Trp Leu Glu Phe 
        675                 680                 685             


Asn Thr Asn Gly Ser Asp Thr Asp Gln Gly Phe Gln Leu Thr Tyr Thr 
    690                 695                 700                 


Ser Phe Asp Leu Val Lys Cys Glu Asp Pro Gly Ile Pro Asn Tyr Gly 
705                 710                 715                 720 


Tyr Arg Ile Arg Asp Glu Gly His Phe Thr Asp Thr Val Val Leu Tyr 
                725                 730                 735     


Ser Cys Asn Pro Gly Tyr Ala Met His Gly Ser Asn Thr Leu Thr Cys 
            740                 745                 750         


Leu Ser Gly Asp Arg Arg Val Trp Asp Lys Pro Leu Pro Ser Cys Ile 
        755                 760                 765             


Ala Glu Cys Gly Gly Gln Ile His Ala Ala Thr Ser Gly Arg Ile Leu 
    770                 775                 780                 


Ser Pro Gly Tyr Pro Ala Pro Tyr Asp Asn Asn Leu His Cys Thr Trp 
785                 790                 795                 800 


Ile Ile Glu Ala Asp Pro Gly Lys Thr Ile Ser Leu His Phe Ile Val 
                805                 810                 815     


Phe Asp Thr Glu Met Ala His Asp Ile Leu Lys Val Trp Asp Gly Pro 
            820                 825                 830         


Val Asp Ser Asp Ile Leu Leu Lys Glu Trp Ser Gly Ser Ala Leu Pro 
        835                 840                 845             


Glu Asp Ile His Ser Thr Phe Asn Ser Leu Thr Leu Gln Phe Asp Ser 
    850                 855                 860                 


Asp Phe Phe Ile Ser Lys Ser Gly Phe Ser Ile Gln Phe Ser Thr Ser 
865                 870                 875                 880 


Ile Ala Ala Thr Cys Asn Asp Pro Gly Met Pro Gln Asn Gly Thr Arg 
                885                 890                 895     


Tyr Gly Asp Ser Arg Glu Ala Gly Asp Thr Val Thr Phe Gln Cys Asp 
            900                 905                 910         


Pro Gly Tyr Gln Leu Gln Gly Gln Ala Lys Ile Thr Cys Val Gln Leu 
        915                 920                 925             


Asn Asn Arg Phe Phe Trp Gln Pro Asp Pro Pro Thr Cys Ile Ala Ala 
    930                 935                 940                 


Cys Gly Gly Asn Leu Thr Gly Pro Ala Gly Val Ile Leu Ser Pro Asn 
945                 950                 955                 960 


Tyr Pro Gln Pro Tyr Pro Pro Gly Lys Glu Cys Asp Trp Arg Val Lys 
                965                 970                 975     


Val Asn Pro Asp Phe Val Ile Ala Leu Ile Phe Lys Ser Phe Asn Met 
            980                 985                 990         


Glu Pro Ser Tyr Asp Phe Leu His  Ile Tyr Glu Gly Glu  Asp Ser Asn 
        995                 1000                 1005             


Ser Pro  Leu Ile Gly Ser Tyr  Gln Gly Ser Gln Ala  Pro Glu Arg 
    1010                 1015                 1020             


Ile Glu  Ser Ser Gly Asn Ser  Leu Phe Leu Ala Phe  Arg Ser Asp 
    1025                 1030                 1035             


Ala Ser  Val Gly Leu Ser Gly  Phe Ala Ile Glu Phe  Lys Glu Lys 
    1040                 1045                 1050             


Pro Arg  Glu Ala Cys Phe Asp  Pro Gly Asn Ile Met  Asn Gly Thr 
    1055                 1060                 1065             


Arg Val  Gly Thr Asp Phe Lys  Leu Gly Ser Thr Ile  Thr Tyr Gln 
    1070                 1075                 1080             


Cys Asp  Ser Gly Tyr Lys Ile  Leu Asp Pro Ser Ser  Ile Thr Cys 
    1085                 1090                 1095             


Val Ile  Gly Ala Asp Gly Lys  Pro Ser Trp Asp Gln  Val Leu Pro 
    1100                 1105                 1110             


Ser Cys  Asn Ala Pro Cys Gly  Gly Gln Tyr Thr Gly  Ser Glu Gly 
    1115                 1120                 1125             


Val Val  Leu Ser Pro Asn Tyr  Pro His Asn Tyr Thr  Ala Gly Gln 
    1130                 1135                 1140             


Ile Cys  Leu Tyr Ser Ile Thr  Val Pro Lys Glu Phe  Val Val Phe 
    1145                 1150                 1155             


Gly Gln  Phe Ala Tyr Phe Gln  Thr Ala Leu Asn Asp  Leu Ala Glu 
    1160                 1165                 1170             


Leu Phe  Asp Gly Thr His Ala  Gln Ala Arg Leu Leu  Ser Ser Leu 
    1175                 1180                 1185             


Ser Gly  Ser His Ser Gly Glu  Thr Leu Pro Leu Ala  Thr Ser Asn 
    1190                 1195                 1200             


Gln Ile  Leu Leu Arg Phe Ser  Ala Lys Ser Gly Ala  Ser Ala Arg 
    1205                 1210                 1215             


Gly Phe  His Phe Val Tyr Gln  Ala Val Pro Arg Thr  Ser Asp Thr 
    1220                 1225                 1230             


Gln Cys  Ser Ser Val Pro Glu  Pro Arg Tyr Gly Arg  Arg Ile Gly 
    1235                 1240                 1245             


Ser Glu  Phe Ser Ala Gly Ser  Ile Val Arg Phe Glu  Cys Asn Pro 
    1250                 1255                 1260             


Gly Tyr  Leu Leu Gln Gly Ser  Thr Ala Leu His Cys  Gln Ser Val 
    1265                 1270                 1275             


Pro Asn  Ala Leu Ala Gln Trp  Asn Asp Thr Ile Pro  Ser Cys Val 
    1280                 1285                 1290             


Val Pro  Cys Ser Gly Asn Phe  Thr Gln Arg Arg Gly  Thr Ile Leu 
    1295                 1300                 1305             


Ser Pro  Gly Tyr Pro Glu Pro  Tyr Gly Asn Asn Leu  Asn Cys Ile 
    1310                 1315                 1320             


Trp Lys  Ile Ile Val Thr Glu  Gly Ser Gly Ile Gln  Ile Gln Val 
    1325                 1330                 1335             


Ile Ser  Phe Ala Thr Glu Gln  Asn Trp Asp Ser Leu  Glu Ile His 
    1340                 1345                 1350             


Asp Gly  Gly Asp Val Thr Ala  Pro Arg Leu Gly Ser  Phe Ser Gly 
    1355                 1360                 1365             


Thr Thr  Val Pro Ala Leu Leu  Asn Ser Thr Ser Asn  Gln Leu Tyr 
    1370                 1375                 1380             


Leu His  Phe Gln Ser Asp Ile  Ser Val Ala Ala Ala  Gly Phe His 
    1385                 1390                 1395             


Leu Glu  Tyr Lys Thr Val Gly  Leu Ala Ala Cys Gln  Glu Pro Ala 
    1400                 1405                 1410             


Leu Pro  Ser Asn Ser Ile Lys  Ile Gly Asp Arg Tyr  Met Val Asn 
    1415                 1420                 1425             


Asp Val  Leu Ser Phe Gln Cys  Glu Pro Gly Tyr Thr  Leu Gln Gly 
    1430                 1435                 1440             


Arg Ser  His Ile Ser Cys Met  Pro Gly Thr Val Arg  Arg Trp Asn 
    1445                 1450                 1455             


Tyr Pro  Ser Pro Leu Cys Ile  Ala Thr Cys Gly Gly  Thr Leu Ser 
    1460                 1465                 1470             


Thr Leu  Gly Gly Val Ile Leu  Ser Pro Gly Phe Pro  Gly Ser Tyr 
    1475                 1480                 1485             


Pro Asn  Asn Leu Asp Cys Thr  Trp Arg Ile Ser Leu  Pro Ile Gly 
    1490                 1495                 1500             


Tyr Gly  Ala His Ile Gln Phe  Leu Asn Phe Ser Thr  Glu Ala Asn 
    1505                 1510                 1515             


His Asp  Phe Leu Glu Ile Gln  Asn Gly Pro Tyr His  Thr Ser Pro 
    1520                 1525                 1530             


Met Ile  Gly Gln Phe Ser Gly  Thr Asp Leu Pro Ala  Ala Leu Leu 
    1535                 1540                 1545             


Ser Thr  Thr His Glu Thr Leu  Ile His Phe Tyr Ser  Asp His Ser 
    1550                 1555                 1560             


Gln Asn  Arg Gln Gly Phe Lys  Leu Ala Tyr Gln Ala  Tyr Glu Leu 
    1565                 1570                 1575             


Gln Asn  Cys Pro Asp Pro Pro  Pro Phe Gln Asn Gly  Tyr Met Ile 
    1580                 1585                 1590             


Asn Ser  Asp Tyr Ser Val Gly  Gln Ser Val Ser Phe  Glu Cys Tyr 
    1595                 1600                 1605             


Pro Gly  Tyr Ile Leu Ile Gly  His Pro Val Leu Thr  Cys Gln His 
    1610                 1615                 1620             


Gly Ile  Asn Arg Asn Trp Asn  Tyr Pro Phe Pro Arg  Cys Asp Ala 
    1625                 1630                 1635             


Pro Cys  Gly Tyr Asn Val Thr  Ser Gln Asn Gly Thr  Ile Tyr Ser 
    1640                 1645                 1650             


Pro Gly  Phe Pro Asp Glu Tyr  Pro Ile Leu Lys Asp  Cys Ile Trp 
    1655                 1660                 1665             


Leu Ile  Thr Val Pro Pro Gly  His Gly Val Tyr Ile  Asn Phe Thr 
    1670                 1675                 1680             


Leu Leu  Gln Thr Glu Ala Val  Asn Asp Tyr Ile Ala  Val Trp Asp 
    1685                 1690                 1695             


Gly Pro  Asp Gln Asn Ser Pro  Gln Leu Gly Val Phe  Ser Gly Asn 
    1700                 1705                 1710             


Thr Ala  Leu Glu Thr Ala Tyr  Ser Ser Thr Asn Gln  Val Leu Leu 
    1715                 1720                 1725             


Lys Phe  His Ser Asp Phe Ser  Asn Gly Gly Phe Phe  Val Leu Asn 
    1730                 1735                 1740             


Phe His  Ala Phe Gln Leu Lys  Lys Cys Gln Pro Pro  Pro Ala Val 
    1745                 1750                 1755             


Pro Gln  Ala Glu Met Leu Thr  Glu Asp Asp Asp Phe  Glu Ile Gly 
    1760                 1765                 1770             


Asp Phe  Val Lys Tyr Gln Cys  His Pro Gly Tyr Thr  Leu Val Gly 
    1775                 1780                 1785             


Thr Asp  Ile Leu Thr Cys Lys  Leu Ser Ser Gln Leu  Gln Phe Glu 
    1790                 1795                 1800             


Gly Ser  Leu Pro Thr Cys Glu  Ala Gln Cys Pro Ala  Asn Glu Val 
    1805                 1810                 1815             


Arg Thr  Gly Ser Ser Gly Val  Ile Leu Ser Pro Gly  Tyr Pro Gly 
    1820                 1825                 1830             


Asn Tyr  Phe Asn Ser Gln Thr  Cys Ser Trp Ser Ile  Lys Val Glu 
    1835                 1840                 1845             


Pro Asn  Tyr Asn Ile Thr Ile  Phe Val Asp Thr Phe  Gln Ser Glu 
    1850                 1855                 1860             


Lys Gln  Phe Asp Ala Leu Glu  Val Phe Asp Gly Ser  Ser Gly Gln 
    1865                 1870                 1875             


Ser Pro  Leu Leu Val Val Leu  Ser Gly Asn His Thr  Glu Gln Ser 
    1880                 1885                 1890             


Asn Phe  Thr Ser Arg Ser Asn  Gln Leu Tyr Leu Arg  Trp Ser Thr 
    1895                 1900                 1905             


Asp His  Ala Thr Ser Lys Lys  Gly Phe Lys Ile Arg  Tyr Ala Ala 
    1910                 1915                 1920             


Pro Tyr  Cys Ser Leu Thr His  Pro Leu Lys Asn Gly  Gly Ile Leu 
    1925                 1930                 1935             


Asn Arg  Thr Ala Gly Ala Val  Gly Ser Lys Val His  Tyr Phe Cys 
    1940                 1945                 1950             


Lys Pro  Gly Tyr Arg Met Val  Gly His Ser Asn Ala  Thr Cys Arg 
    1955                 1960                 1965             


Arg Asn  Pro Leu Gly Met Tyr  Gln Trp Asp Ser Leu  Thr Pro Leu 
    1970                 1975                 1980             


Cys Gln  Ala Val Ser Cys Gly  Ile Pro Glu Ser Pro  Gly Asn Gly 
    1985                 1990                 1995             


Ser Phe  Thr Gly Asn Glu Phe  Thr Leu Asp Ser Lys  Val Val Tyr 
    2000                 2005                 2010             


Glu Cys  His Glu Gly Phe Lys  Leu Glu Ser Ser Gln  Gln Ala Thr 
    2015                 2020                 2025             


Ala Val  Cys Gln Glu Asp Gly  Leu Trp Ser Asn Lys  Gly Lys Pro 
    2030                 2035                 2040             


Pro Thr  Cys Lys Pro Val Ala  Cys Pro Ser Ile Glu  Ala Gln Leu 
    2045                 2050                 2055             


Ser Glu  His Val Ile Trp Arg  Leu Val Ser Gly Ser  Leu Asn Glu 
    2060                 2065                 2070             


Tyr Gly  Ala Gln Val Leu Leu  Ser Cys Ser Pro Gly  Tyr Tyr Leu 
    2075                 2080                 2085             


Glu Gly  Trp Arg Leu Leu Arg  Cys Gln Ala Asn Gly  Thr Trp Asn 
    2090                 2095                 2100             


Ile Gly  Asp Glu Arg Pro Ser  Cys Arg Ala Gly His  Cys Gly Ser 
    2105                 2110                 2115             


Pro Asp  Pro Ile Val Asn Gly  His Ile Ser Gly Asp  Gly Phe Ser 
    2120                 2125                 2130             


Tyr Arg  Asp Thr Val Val Tyr  Gln Cys Asn Pro Gly  Phe Arg Leu 
    2135                 2140                 2145             


Val Gly  Thr Ser Val Arg Ile  Cys Leu Gln Asp His  Lys Trp Ser 
    2150                 2155                 2160             


Gly Gln  Thr Pro Val Cys Val  Pro Ile Thr Cys Gly  His Pro Gly 
    2165                 2170                 2175             


Asn Pro  Ala His Gly Phe Thr  Asn Gly Ser Glu Phe  Asn Leu Asn 
    2180                 2185                 2190             


Asp Val  Val Asn Phe Thr Cys  Asn Thr Gly Tyr Leu  Leu Gln Gly 
    2195                 2200                 2205             


Val Ser  Arg Ala Gln Cys Arg  Ser Asn Gly Gln Trp  Ser Ser Pro 
    2210                 2215                 2220             


Leu Pro  Thr Cys Arg Val Val  Asn Cys Ser Asp Pro  Gly Phe Val 
    2225                 2230                 2235             


Glu Asn  Ala Ile Arg His Gly  Gln Gln Asn Phe Pro  Glu Ser Phe 
    2240                 2245                 2250             


Glu Tyr  Gly Met Ser Ile Leu  Tyr His Cys Lys Lys  Gly Phe Tyr 
    2255                 2260                 2265             


Leu Leu  Gly Ser Ser Ala Leu  Thr Cys Met Ala Asn  Gly Leu Trp 
    2270                 2275                 2280             


Asp Arg  Ser Leu Pro Lys Cys  Leu Ala Ile Ser Cys  Gly His Pro 
    2285                 2290                 2295             


Gly Val  Pro Ala Asn Ala Val  Leu Thr Gly Glu Leu  Phe Thr Tyr 
    2300                 2305                 2310             


Gly Ala  Val Val His Tyr Ser  Cys Arg Gly Ser Glu  Ser Leu Ile 
    2315                 2320                 2325             


Gly Asn  Asp Thr Arg Val Cys  Gln Glu Asp Ser His  Trp Ser Gly 
    2330                 2335                 2340             


Ala Leu  Pro His Cys Thr Gly  Asn Asn Pro Gly Phe  Cys Gly Asp 
    2345                 2350                 2355             


Pro Gly  Thr Pro Ala His Gly  Ser Arg Leu Gly Asp  Asp Phe Lys 
    2360                 2365                 2370             


Thr Lys  Ser Leu Leu Arg Phe  Ser Cys Glu Met Gly  His Gln Leu 
    2375                 2380                 2385             


Arg Gly  Ser Pro Glu Arg Thr  Cys Leu Leu Asn Gly  Ser Trp Ser 
    2390                 2395                 2400             


Gly Leu  Gln Pro Val Cys Glu  Ala Val Leu Cys Pro  Gln Pro Pro 
    2405                 2410                 2415             


Pro Val  Gln Asn Gly Thr Val  Glu Gly Ser Asp Phe  Arg Trp Gly 
    2420                 2425                 2430             


Ser Ser  Ile Ser Tyr Ser Cys  Met Asp Gly Tyr Gln  Leu Ser His 
    2435                 2440                 2445             


Ser Ala  Ile Leu Ser Cys Glu  Gly Arg Gly Val Trp  Lys Gly Glu 
    2450                 2455                 2460             


Ile Pro  Gln Cys Leu Pro Val  Phe Cys Gly Asp Pro  Gly Ile Pro 
    2465                 2470                 2475             


Ala Glu  Gly Arg Leu Ser Gly  Lys Ser Phe Thr Tyr  Lys Ser Glu 
    2480                 2485                 2490             


Val Phe  Phe Gln Cys Lys Ser  Pro Phe Ile Leu Val  Gly Ser Ser 
    2495                 2500                 2505             


Arg Arg  Val Cys Gln Ala Asp  Gly Thr Trp Ser Gly  Ile Gln Pro 
    2510                 2515                 2520             


Thr Cys  Ile Asp Pro Ala His  Asn Thr Cys Pro Asp  Pro Gly Thr 
    2525                 2530                 2535             


Pro His  Phe Gly Ile Gln Asn  Ser Ser Arg Gly Tyr  Glu Val Gly 
    2540                 2545                 2550             


Ser Thr  Val Phe Phe Arg Cys  Arg Lys Gly Tyr His  Ile Gln Gly 
    2555                 2560                 2565             


Ser Thr  Thr Arg Thr Cys Leu  Ala Asn Leu Thr Trp  Ser Gly Ile 
    2570                 2575                 2580             


Gln Thr  Glu Cys Ile Pro His  Ala Cys Arg Gln Pro  Glu Thr Pro 
    2585                 2590                 2595             


Ala His  Ala Asp Val Arg Ala  Ile Asp Leu Pro Thr  Phe Gly Tyr 
    2600                 2605                 2610             


Thr Leu  Val Tyr Thr Cys His  Pro Gly Phe Phe Leu  Ala Gly Gly 
    2615                 2620                 2625             


Ser Glu  His Arg Thr Cys Lys  Ala Asp Met Lys Trp  Thr Gly Lys 
    2630                 2635                 2640             


Ser Pro  Val Cys Lys Ser Lys  Gly Val Arg Glu Val  Asn Glu Thr 
    2645                 2650                 2655             


Val Thr  Lys Thr Pro Val Pro  Ser Asp Val Phe Phe  Val Asn Ser 
    2660                 2665                 2670             


Leu Trp  Lys Gly Tyr Tyr Glu  Tyr Leu Gly Lys Arg  Gln Pro Ala 
    2675                 2680                 2685             


Thr Leu  Thr Val Asp Trp Phe  Asn Ala Thr Ser Ser  Lys Val Asn 
    2690                 2695                 2700             


Ala Thr  Phe Ser Glu Ala Ser  Pro Val Glu Leu Lys  Leu Thr Gly 
    2705                 2710                 2715             


Ile Tyr  Lys Lys Glu Glu Ala  His Leu Leu Leu Lys  Ala Phe Gln 
    2720                 2725                 2730             


Ile Lys  Gly Gln Ala Asp Ile  Phe Val Ser Lys Phe  Glu Asn Asp 
    2735                 2740                 2745             


Asn Trp  Gly Leu Asp Gly Tyr  Val Ser Ser Gly Leu  Glu Arg Gly 
    2750                 2755                 2760             


Gly Phe  Thr Phe Gln Gly Asp  Ile His Gly Lys Asp  Phe Gly Lys 
    2765                 2770                 2775             


Phe Lys  Leu Glu Arg Gln Asp  Pro Leu Asn Pro Asp  Gln Asp Ser 
    2780                 2785                 2790             


Ser Ser  His Tyr His Gly Thr  Ser Ser Gly Ser Val  Ala Ala Ala 
    2795                 2800                 2805             


Ile Leu  Val Pro Phe Phe Ala  Leu Ile Leu Ser Gly  Phe Ala Phe 
    2810                 2815                 2820             


Tyr Leu  Tyr Lys His Arg Thr  Arg Pro Lys Val Gln  Tyr Asn Gly 
    2825                 2830                 2835             


Tyr Ala  Gly His Glu Asn Ser  Asn Gly Gln Ala Ser  Phe Glu Asn 
    2840                 2845                 2850             


Pro Met  Tyr Asp Thr Asn Leu  Lys Pro Thr Glu Ala  Lys Ala Val 
    2855                 2860                 2865             


Arg Phe  Asp Thr Thr Leu Asn  Thr Val Cys Thr Val  Val 
    2870                 2875                 2880     

<210>  2432
<211>  11804
<212>  DNA
<213>  Homo sapiens

<400>  2432
tcttctgcgc tctccgcctt ttctctctag actggatctc tcctcccccc cgcgcccccc     60

tccccgcatc tcccactcgc tggctctctc tccagctgcc tcctctccag gtctctcctg    120

gctgcgcgcg ctcctctccc cgcttctccc cctcccgcag cctcgccgcc ttggtgcctt    180

cctgcccggc tcggccggcg ctcgtccccg gccccggccc cgccagcccg ggtctccgcg    240

ctcggagcag ctcagccctg cagtggctcg ggacccgatg ctatgagagg gaagcgagcc    300

gggcgcccag accttcagga ggcgtcggat gcgcggcggg tcttgggacc gggctctctc    360

tccggctcgc cttgccctcg ggtgattatt tggctccgct catagccctg ccttcctcgg    420

aggagccatc ggtgtcgcgt gcgtgtggag tatctgcaga catgactgcg tggaggagat    480

tccagtcgct gctcctgctt ctcgggctgc tggtgctgtg cgcgaggctc ctcactgcag    540

cgaagggtca gaactgtgga ggcttagtcc agggtcccaa tggcactatt gagagcccag    600

ggtttcctca cgggtatccg aactatgcca actgcacctg gatcatcatc acgggcgagc    660

gcaataggat acagttgtcc ttccatacct ttgctcttga agaagatttt gatattttat    720

cagtttacga tggacagcct caacaaggga atttaaaagt gagattatcg ggatttcagc    780

tgccctcctc tatagtgagt acaggatcta tcctcactct gtggttcacg acagacttcg    840

ctgtgagtgc ccaaggtttc aaagcattat atgaagtttt acctagccac acttgtggaa    900

atcctggaga aatcctgaaa ggagttctgc atggaacgag attcaacata ggagacaaaa    960

tccggtacag ctgcctccct ggctacatct tggaaggcca cgccatcctg acctgcatcg   1020

tcagcccagg aaatggtgca tcgtgggact tcccagctcc cttttgcaga gctgagggag   1080

cctgcggagg aaccttacgc gggaccagca gctccatctc cagcccgcac ttcccttcag   1140

agtacgagaa caacgcggac tgcacctgga ccattctggc tgagcccggg gacaccattg   1200

cgctggtctt cactgacttt cagctagaag aaggatatga tttcttagag atcagtggca   1260

cggaagctcc atccatatgg ctaactggca tgaacctccc ctctccagtt atcagtagca   1320

agaattggct acgactccat ttcacctctg acagcaacca ccgacgcaaa ggatttaacg   1380

ctcagttcca agtgagccaa ggaggtgttg cattggtctc tgacatgtgt ccagatcctg   1440

ggattccaga aaatggtaga agagcaggtt ccgaggctta gggttggtgc aaatgtacag   1500

ttttcatgtg aggacaatta cgtgctccag ggatctaaaa gcatcacctg tcagagagtt   1560

acagagacgc tcgctgcttg gagtgaccac aggcccatct gccgagcgag aacatgtgga   1620

tccaatctgc gtgggcccag cggcgtcatt acctccccta attatccggt tcagtatgaa   1680

gataatgcac actgtgtgtg ggtcatcacc accaccgacc cggacaaggt catcaagctt   1740

gcctttgaag agtttgagct ggagcgaggc tatgacaccc tgacggttgg tgatgctggg   1800

aaggtgggag acaccagatc ggtcttgtac gtgctcacgg gatccagtgt tcctgacctc   1860

attgtgagca tgagcaacca gatgtggcta catctgcagt cggatgatag cattggctca   1920

cctgggttta aagctgttta ccaagaaatt gaaaagggag ggtgtgggga tcctggaatc   1980

cccgcctatg ggaagcggac gggcagcagt ttcctccatg gagatacact cacctttgaa   2040

tgcccggcgg cctttgagct ggtgggggga gagagttatc acctgtcagc agaacaatca   2100

gtggtctggc aacaagccca gctgtgtatt ttcatgtttc ttcaacttta cggcatcatc   2160

tgggattatt ctgtcaccaa attatccaga ggaatatggg aacaacatga actgtgtctg   2220

gttgattatc tcggagccag gaagtcgaat tcacctaatc tttaatgatt ttgatgttga   2280

gcctcagttt gactttctcg cggtcaagga tgatggcatt tctgacataa ctgtcctggg   2340

tactttttct ggcaatgaag tgccttccca gctggccagc agtgggcata tagttcgctt   2400

ggaatttcag tctgaccatt ccactactgg cagagggttc aacatcactt acaccacatt   2460

tggtcagaat gagtgccatg atcctggcat tcctataaac ggacgacgtt ttggtgacag   2520

gtttctactc gggagctcgg tttctttcca ctgtgatgat ggctttgtca agacccaggg   2580

atccgagtcc attacctgca tactgcaaga cgggaacgtg gtctggagct ccaccgtgcc   2640

ccgctgtgaa gctccatgtg gtggacatct gacagcgtcc agcggagtca ttttgcctcc   2700

tggatggcca ggatattata aggattcttt acattgtgaa tggataattg aagcaaaacc   2760

aggccactct atcaaaataa cttttgacag atttcagaca gaggtcaatt atgacacctt   2820

ggaggtcaga gatgggccag ccagttcgtc cccactgatc ggcgagtacc acggcaccca   2880

ggcaccccag ttcctcatca gcaccgggaa cttcatgtac ctgctgttca ccactgacaa   2940

cagccgctcc agcatcggct tcctcatcca ctatgagagt gtgacgcttg agtcggattc   3000

ctgcctggac ccgggcatcc ctgtgaacgg ccatcgccac ggtggagact ttggcatcag   3060

gtccacagtg actttcagct gtgacccggg gtacacacta agtgacgacg agcccctcgt   3120

ctgtgagagg aaccaccagt ggaaccacgc cttgcccagc tgcgacgctc tatgtggagg   3180

ctacatccaa gggaagagtg gaacagtcct ttctcctggg tttccagatt tttatccaaa   3240

ctctctaaac tgcacgtgga ccattgaagt gtctcatggg aaaggagttc aaatgatctt   3300

tcacaccttt catcttgaga gttcccacga ctatttactg atcacagagg atggaagttt   3360

ttccgagccc gttgccaggc tcaccgggtc ggtgttgcct catacgatca aggcaggcct   3420

gtttggaaac ttcactgccc agcttcggtt tatatcagac ttctcaattt cgtacgaggg   3480

cttcaatatc acattttcag aatatgacct ggagccatgt gatgatcctg gagtccctgc   3540

cttcagccga agaattggtt ttcactttgg tgtgggagac tctctgacgt tttcctgctt   3600

cctgggatat cgtttagaag gtgccaccaa gcttacctgc ctgggtgggg gccgccgtgt   3660

gtggagtgca cctctgccaa ggtgtgtggc cgaatgtgga gcaagtgtca aaggaaatga   3720

aggaacatta ctgtctccaa attttccatc caattatgat aataaccatg agtgtatcta   3780

taaaatagaa acagaagccg gcaagggcat ccaccttaga acacgaagct tccagctgtt   3840

tgaaggagat actctaaagg tatatgatgg aaaagacagt tcctcacgtc cactgggcac   3900

gttcactaaa aatgaacttc tggggctgat cctaaacagc acatccaatc acctgtggct   3960

agagttcaac accaatggat ctgacaccga ccaaggtttt caactcacct ataccagttt   4020

tgatctggta aaatgtgagg atccgggcat ccctaactac ggctatagga tccgtgatga   4080

aggccacttt accgacactg tagttctgta cagttgcaac ccggggtacg ccatgcatgg   4140

cagcaacacc ctgacctgtt tgagtggaga caggagagtg tgggacaaac cactaccttc   4200

gtgcatagcg gaatgtggtg gtcagatcca tgcagccaca tcaggacgaa tattgtcccc   4260

tggctatcca gctccgtatg acaacaacct ccactgcacc tggattatag aggcagaccc   4320

aggaaagacc attagcctcc atttcattgt tttcgacacg gagatggctc acgacatcct   4380

caaggtctgg gacgggccgg tggacagtga catcctgctg aaggagtgga gtggctccgc   4440

ccttccggag gacatccaca gcaccttcaa ctcactcacc ctgcagttcg acagcgactt   4500

cttcatcagc aagtctggct tctccatcca gttctccacc tcaattgcag ccacctgtaa   4560

cgatccaggt atgccccaaa atggcacccg ctatggagac agcagagagg ctggagacac   4620

cgtcacattc cagtgtgacc ctggctatca gctccaagga caagccaaaa tcacctgtgt   4680

gcagctgaat aaccggttct tttggcaacc agaccctcct acatgcatag ctgcttgtgg   4740

agggaatctg acgggcccag caggtgttat tttgtcaccc aactacccac agccgtatcc   4800

tcctgggaag gaatgtgact ggagagtaaa agtgaacccg gactttgtca tcgccttgat   4860

attcaaaagt ttcaacatgg agcccagcta tgacttccta cacatctatg aaggggaaga   4920

ttccaacagc cccctcattg ggagttacca gggctctcag gccccagaaa gaatagagag   4980

tagcggaaac agcctgtttc tggcatttcg gagtgatgcc tccgtgggcc tttcagggtt   5040

cgccattgaa tttaaagaga aaccacggga agcttgtttt gacccaggaa atataatgaa   5100

tgggacaaga gttggaacag acttcaagct tggctccacc atcacctacc agtgtgactc   5160

tggctataag attcttgacc cctcatccat cacctgtgtg attggggctg atgggaaacc   5220

ctcctgggac caagtgctgc cctcctgcaa tgctccctgt ggaggccagt acacgggatc   5280

agaaggggta gttttatcac caaactaccc ccataattac acagctggtc aaatatgcct   5340

ctattccatc acggtaccaa aggaattcgt ggtctttgga cagtttgcct atttccagac   5400

agccctgaat gatttggcag aattatttga tggaacccat gcacaggcca gacttctcag   5460

ctcactctcg gggtctcact caggggaaac attgcccttg gctacgtcaa atcaaattct   5520

gctccgattc agtgcaaaga gcggtgcctc tgcccgcggc ttccacttcg tgtatcaagc   5580

tgttcctcgt accagtgaca cccaatgcag ctctgtcccc gagcccagat acggaaggag   5640

aattggttct gagttttctg ccggctccat cgtccgattc gagtgcaacc cgggatacct   5700

gcttcagggt tccacggcgc tccactgcca gtccgtgccc aacgccttgg cacagtggaa   5760

cgacacgatc cccagctgtg tggtaccctg cagtggcaat ttcactcaac gaagaggtac   5820

aatcctgtcc cccggctacc ctgagccata cggaaacaac ttgaactgta tatggaagat   5880

catagttacg gagggctcgg gaattcagat ccaagtgatc agttttgcca cggagcagaa   5940

ctgggactcc cttgagatcc acgatggtgg ggatgtgacc gcacccagac tgggaagctt   6000

ctcaggcacc acagtaccgg cactgctgaa cagtacttcc aaccaactct acctgcattt   6060

ccagtctgac attagtgtgg cagctgctgg tttccacctg gaatacaaaa ctgtaggtct   6120

tgctgcatgc caagaaccag ccctccccag caacagcatc aaaatcggag atcggtacat   6180

ggtgaacgac gtgctctcct tccagtgcga gcccgggtac accctgcagg gccgttccca   6240

catttcctgt atgccaggga ccgttcgccg ttggaactat ccgtctcccc tgtgcattgc   6300

aacctgtgga gggacgctga gcaccttggg tggtgtgatc ctgagccccg gcttcccagg   6360

ttcttacccc aacaacttag actgcacctg gaggatctca ttacccatcg gctatggtgc   6420

acatattcag tttctgaatt tttctaccga agctaatcat gacttccttg aaattcaaaa   6480

tggaccttac cacaccagcc ccatgattgg acaatttagc ggcacggatc tccccgcggc   6540

cctgctgagc acaacgcatg aaaccctcat ccacttttat agtgaccatt cgcaaaaccg   6600

gcaaggattt aaacttgctt accaagccta tgaattacag aactgtccag atccaccccc   6660

atttcagaat gggtacatga tcaactcgga ttacagcgtg gggcaatcag tatctttcga   6720

gtgttatcct gggtacattc taataggcca tcctgtcctc acttgtcagc atgggatcaa   6780

cagaaactgg aactaccctt ttccaagatg tgatgcccct tgtgggtaca acgtaacttc   6840

tcagaacggc accatctact cccctggctt tcctgatgag tatccgatcc tgaaggactg   6900

catttggctc atcacggtgc ctccagggca cggagtttac atcaacttca ccctgttaca   6960

gacggaagct gtcaacgatt acattgctgt ttgggacggt cccgatcaga actcacccca   7020

gctgggagtt ttcagtggca acacagccct cgaaacggcg tatagctcca ccaaccaagt   7080

cctgctcaag ttccacagcg acttttcaaa tggaggcttc tttgtcctca atttccacgc   7140

atttcagctc aagaaatgtc aacctccccc agcggttcca caggcagaaa tgcttactga   7200

ggatgatgat ttcgaaatag gagattttgt gaagtaccag tgccaccccg ggtacacctt   7260

ggtggggacc gacattctga cttgcaagct cagttcccag ttgcagtttg agggttctct   7320

cccaacatgt gaagcacaat gcccagcaaa tgaagtccgg actggatcat cgggagtcat   7380

tctcagtcca gggtatccgg gtaattattt taactcccag acttgctctt ggagtattaa   7440

agtggaacca aactacaaca ttaccatctt tgtggacaca tttcaaagtg aaaagcagtt   7500

tgatgcactg gaagtgtttg atggttcttc tgggcaaagt cctctgctag tagtcttaag   7560

tgggaatcat actgaacaat caaattttac aagcaggagt aatcagttat atctccgctg   7620

gtccactgac catgccacca gtaagaaagg attcaagatt cgctatgcag caccttactg   7680

cagtttgacc caccccctga agaatggggg tattctaaac aggactgcag gagcggttgg   7740

aagcaaagtg cattattttt gcaagcctgg ataccgaatg gtcggccaca gcaatgcaac   7800

ctgtagacga aacccacttg gcatgtacca gtgggactcc ctcacgccac tctgccaggc   7860

tgtgtcctgt ggaatcccag aatccccagg aaacggttca tttaccggga acgagttcac   7920

tttggacagt aaagtggtct atgaatgtca tgagggcttc aagcttgaat ccagccagca   7980

agcaacagcc gtgtgtcaag aagatgggtt gtggagtaac aaggggaagc cgcccacgtg   8040

taagccggtc gcttgcccca gcattgaagc tcagctctca gaacatgtca tctggaggct   8100

ggtttcagga tccttgaatg agtacggtgc tcaagtattg ctgagctgca gtcctggtta   8160

ctacttagaa ggctggaggc tcctgcggtg ccaggccaat gggacgtgga acataggaga   8220

tgagaggcca agctgtcgag ttatctcgtg tggaagcctt tcctttcccc caaatggcaa   8280

caagattgga acgttgacag tttatggggc cacagctata tttacgtgca acaccggcta   8340

cacgcttgtg gggtctcatg tcagagagtg cttggcaaat gggctctgga gcggcagcga   8400

aactcgatgt ctggctggcc actgcggttc cccagacccg attgtgaacg gtcacattag   8460

tggagatggc ttcagttaca gagacacggt ggtttaccag tgcaatcctg gtttccggct   8520

tgtgggaact tccgtgagga tatgcctgca agaccacaag tggtctggac aaacgcctgt   8580

ctgtgtcccc atcacatgtg gtcaccctgg aaaccctgcc cacggattca ctaatggcag   8640

tgagttcaac ctgaatgatg tcgtgaattt cacctgcaac acgggctatt tgctgcaggg   8700

cgtgtctcga gcccagtgtc ggagcaacgg ccagtggagt agccctctgc ccacgtgtcg   8760

agtggtgaac tgttctgatc caggctttgt ggaaaatgcc attcgtcacg ggcaacagaa   8820

cttccctgag agttttgagt atggaatgag tatcctgtac cattgcaaga agggatttta   8880

cttgctggga tcttcagcct tgacctgtat ggcaaatggc ttatgggacc gatccctgcc   8940

caagtgtttg gctatatcgt gtggacaccc aggggtccct gccaacgccg tcctcactgg   9000

agagctgttt acctatggcg ccgtcgtgca ctactcctgc agagggagcg agagcctcat   9060

aggcaacgac acgagagtgt gccaggaaga cagtcactgg agcggggcac tgccccactg   9120

cacaggaaat aatcctggat tctgtggtga tccggggacc ccagcacatg ggtctcggct   9180

tggtgatgac tttaagacaa agagtcttct ccgcttctcc tgtgaaatgg ggcaccagct   9240

gaggggctcc cctgaacgca cgtgtttgct caatgggtca tggtcaggac tgcagccggt   9300

gtgtgaggcc gtgtcctgtg gcaaccctgg cacacccacc aacggaatga ttgtcagtag   9360

tgatggcatt ctgttctcca gctcggtcat ctatgcctgc tgggaaggct acaagacctc   9420

agggctcatg acacggcatt gcacagccaa tgggacctgg acaggcactg ctcccgactg   9480

cacaattata agttgtgggg atccaggcac actagcaaat ggcatccagt ttgggaccga   9540

cttcaccttc aacaagactg tgagctatca gtgtaaccca ggctatgtca tggaagcagt   9600

cacatccgcc actattcgct gtaccaaaga cggcaggtgg aatccgagca aacctgtctg   9660

caaagccgtg ctgtgtcctc agccgccgcc ggtgcagaat ggaacagtgg agggaagtga   9720

tttccgctgg ggctccagca taagttacag ctgcatggac ggttaccagc tctctcactc   9780

cgccatcctc tcctgtgaag gtcgcggggt gtggaaagga gagatccccc agtgtctccc   9840

tgtgttctgc ggagaccctg gcatccccgc agaagggcga cttagtggga aaagtttcac   9900

ctataagtcc gaagtcttct tccagtgcaa atctccattt atactcgtgg gatcctccag   9960

aagagtctgc caagctgacg gcacgtggag cggcatacaa cccacctgca ttgatcctgc  10020

tcataacacc tgcccagacc ctggtacgcc acactttgga atacagaata gctccagagg  10080

ctatgaggtt ggaagcacgg tttttttcag gtgcagaaaa ggctaccata ttcaaggttc  10140

cacgactcgc acctgccttg ccaatttaac atggagtggg atacagaccg aatgtatacc  10200

tcatgcctgc agacagccag aaaccccggc acacgcggat gtgagagcca tcgatcttcc  10260

tactttcggc tacaccttag tgtacacctg ccatccaggc tttttcctcg cagggggatc  10320

tgagcacaga acatgtaaag cagacatgaa atggacagga aagtcgcctg tgtgtaaaag  10380

taaaggagtg agagaagtta atgaaacagt tactaaaact ccagttcctt cagatgtctt  10440

tttcgtcaat tcactgtgga aggggtatta tgaatattta gggaaaagac aacccgccac  10500

tctaactgtt gactggttca atgcaacaag cagtaaggtg aatgccacct tcagcgaagc  10560

ctcgccagtg gagctgaagt tgacaggcat ttacaagaag gaggaggccc acttactcct  10620

gaaagctttt caaattaaag gccaggcaga tatttttgta agcaagttcg aaaatgacaa  10680

ctggggacta gatggttatg tgtcatctgg acttgaaaga ggaggattta cttttcaagg  10740

tgacattcat ggaaaagact ttggaaaatt taagctagaa aggcaagatc ctttaaaccc  10800

agatcaagac tcttccagtc attaccacgg caccagcagt ggctctgtgg cggctgccat  10860

tctggttcct ttctttgctc taattttatc agggtttgca ttttacctct acaaacacag  10920

aacgagacca aaagttcaat acaatggcta tgctgggcat gaaaacagca atggacaagc  10980

atcgtttgaa aaccccatgt atgatacaaa cttaaaaccc acagaagcca aggctgtgag  11040

gtttgacaca actctgaaca cagtctgtac agtggtatag ccctcagtgc cccaacagga  11100

ctgattcata gccatacctc tgatggacaa gcagtgattc ctttggtgcc atataccact  11160

ctcccttcca ctctggcttt actgcagcga tcttcaacct tgtctactgg cataagtgca  11220

gcggggatct ctactcaaat gtgtcagggt cttctacgga tcaaactaca catgcgtttt  11280

cattccaaaa gtgggttcta aatgcctggc tgcatctgta tgaaatcaag gcacactcca  11340

ggaagactgc cacgtcgcgc caacacgtca tactcaatgc ctcagacttt catatttctg  11400

tgttgctgag atgcctttca atgcaatcgt ctgggctcgt ggatatgtcc ctcaggtgcg  11460

gtgacagaat ggtggcacca cgatatgtgt tctcttgtgt tgtttttcct ttttaaaccc  11520

ccatgaacac gaatactctg aaaaaaataa aaagctttct ggaagaagac acctttctga  11580

tagaggctca cacctacaaa tgcttcactc tgtccttccg agacctgaca agctttgagg  11640

acctcacagc tcccctgtgt gttcatctct agggatgttt gcaatttccc agtcagctgt  11700

tctgtcgcag aatgtttaat gcacaatttt ttgcactagt gtgttatgaa tgactaagat  11760

tctgataaaa aaaataaatt atttacacag ggtttataca cact                   11804


<210>  2433
<211>  3058
<212>  PRT
<213>  Homo sapiens

<400>  2433


Met Ile Ala Leu Ala His Leu Gly Leu Lys Leu Phe Thr Lys Lys Leu 
1               5                   10                  15      


Lys Arg Glu Gly Val Gly Ile Leu Glu Ser Pro Pro Met Gly Ser Gly 
            20                  25                  30          


Arg Ala Ala Val Ser Ser Met Glu Ile His Ser Pro Leu Asn Ala Arg 
        35                  40                  45              


Arg Pro Leu Ser Trp Trp Gly Glu Arg Val Ile Thr Cys Gln Gln Asn 
    50                  55                  60                  


Asn Gln Trp Ser Gly Asn Lys Pro Ser Cys Val Phe Ser Cys Phe Phe 
65                  70                  75                  80  


Asn Phe Thr Ala Ser Ser Gly Ile Ile Leu Ser Pro Asn Tyr Pro Glu 
                85                  90                  95      


Glu Tyr Gly Asn Asn Met Asn Cys Val Trp Leu Ile Ile Ser Glu Pro 
            100                 105                 110         


Gly Ser Arg Ile His Leu Ile Phe Asn Asp Phe Asp Val Glu Pro Gln 
        115                 120                 125             


Phe Asp Phe Leu Ala Val Lys Asp Asp Gly Ile Ser Asp Ile Thr Val 
    130                 135                 140                 


Leu Gly Thr Phe Ser Gly Asn Glu Val Pro Ser Gln Leu Ala Ser Ser 
145                 150                 155                 160 


Gly His Ile Val Arg Leu Glu Phe Gln Ser Asp His Ser Thr Thr Gly 
                165                 170                 175     


Arg Gly Phe Asn Ile Thr Tyr Thr Thr Phe Gly Gln Asn Glu Cys His 
            180                 185                 190         


Asp Pro Gly Ile Pro Ile Asn Gly Arg Arg Phe Gly Asp Arg Phe Leu 
        195                 200                 205             


Leu Gly Ser Ser Val Ser Phe His Cys Asp Asp Gly Phe Val Lys Thr 
    210                 215                 220                 


Gln Gly Ser Glu Ser Ile Thr Cys Ile Leu Gln Asp Gly Asn Val Val 
225                 230                 235                 240 


Trp Ser Ser Thr Val Pro Arg Cys Glu Ala Pro Cys Gly Gly His Leu 
                245                 250                 255     


Thr Ala Ser Ser Gly Val Ile Leu Pro Pro Gly Trp Pro Gly Tyr Tyr 
            260                 265                 270         


Lys Asp Ser Leu His Cys Glu Trp Ile Ile Glu Ala Lys Pro Gly His 
        275                 280                 285             


Ser Ile Lys Ile Thr Phe Asp Arg Phe Gln Thr Glu Val Asn Tyr Asp 
    290                 295                 300                 


Thr Leu Glu Val Arg Asp Gly Pro Ala Ser Ser Ser Pro Leu Ile Gly 
305                 310                 315                 320 


Glu Tyr His Gly Thr Gln Ala Pro Gln Phe Leu Ile Ser Thr Gly Asn 
                325                 330                 335     


Phe Met Tyr Leu Leu Phe Thr Thr Asp Asn Ser Arg Ser Ser Ile Gly 
            340                 345                 350         


Phe Leu Ile His Tyr Glu Ser Val Thr Leu Glu Ser Asp Ser Cys Leu 
        355                 360                 365             


Asp Pro Gly Ile Pro Val Asn Gly His Arg His Gly Gly Asp Phe Gly 
    370                 375                 380                 


Ile Arg Ser Thr Val Thr Phe Ser Cys Asp Pro Gly Tyr Thr Leu Ser 
385                 390                 395                 400 


Asp Asp Glu Pro Leu Val Cys Glu Arg Asn His Gln Trp Asn His Ala 
                405                 410                 415     


Leu Pro Ser Cys Asp Ala Leu Cys Gly Gly Tyr Ile Gln Gly Lys Ser 
            420                 425                 430         


Gly Thr Val Leu Ser Pro Gly Phe Pro Asp Phe Tyr Pro Asn Ser Leu 
        435                 440                 445             


Asn Cys Thr Trp Thr Ile Glu Val Ser His Gly Lys Gly Val Gln Met 
    450                 455                 460                 


Ile Phe His Thr Phe His Leu Glu Ser Ser His Asp Tyr Leu Leu Ile 
465                 470                 475                 480 


Thr Glu Asp Gly Ser Phe Ser Glu Pro Val Ala Arg Leu Thr Gly Ser 
                485                 490                 495     


Val Leu Pro His Thr Ile Lys Ala Gly Leu Phe Gly Asn Phe Thr Ala 
            500                 505                 510         


Gln Leu Arg Phe Ile Ser Asp Phe Ser Ile Ser Tyr Glu Gly Phe Asn 
        515                 520                 525             


Ile Thr Phe Ser Glu Tyr Asp Leu Glu Pro Cys Asp Asp Pro Gly Val 
    530                 535                 540                 


Pro Ala Phe Ser Arg Arg Ile Gly Phe His Phe Gly Val Gly Asp Ser 
545                 550                 555                 560 


Leu Thr Phe Ser Cys Phe Leu Gly Tyr Arg Leu Glu Gly Ala Thr Lys 
                565                 570                 575     


Leu Thr Cys Leu Gly Gly Gly Arg Arg Val Trp Ser Ala Pro Leu Pro 
            580                 585                 590         


Arg Cys Val Ala Glu Cys Gly Ala Ser Val Lys Gly Asn Glu Gly Thr 
        595                 600                 605             


Leu Leu Ser Pro Asn Phe Pro Ser Asn Tyr Asp Asn Asn His Glu Cys 
    610                 615                 620                 


Ile Tyr Lys Ile Glu Thr Glu Ala Gly Lys Gly Ile His Leu Arg Thr 
625                 630                 635                 640 


Arg Ser Phe Gln Leu Phe Glu Gly Asp Thr Leu Lys Val Tyr Asp Gly 
                645                 650                 655     


Lys Asp Ser Ser Ser Arg Pro Leu Gly Thr Phe Thr Lys Asn Glu Leu 
            660                 665                 670         


Leu Gly Leu Ile Leu Asn Ser Thr Ser Asn His Leu Trp Leu Glu Phe 
        675                 680                 685             


Asn Thr Asn Gly Ser Asp Thr Asp Gln Gly Phe Gln Leu Thr Tyr Thr 
    690                 695                 700                 


Ser Phe Asp Leu Val Lys Cys Glu Asp Pro Gly Ile Pro Asn Tyr Gly 
705                 710                 715                 720 


Tyr Arg Ile Arg Asp Glu Gly His Phe Thr Asp Thr Val Val Leu Tyr 
                725                 730                 735     


Ser Cys Asn Pro Gly Tyr Ala Met His Gly Ser Asn Thr Leu Thr Cys 
            740                 745                 750         


Leu Ser Gly Asp Arg Arg Val Trp Asp Lys Pro Leu Pro Ser Cys Ile 
        755                 760                 765             


Ala Glu Cys Gly Gly Gln Ile His Ala Ala Thr Ser Gly Arg Ile Leu 
    770                 775                 780                 


Ser Pro Gly Tyr Pro Ala Pro Tyr Asp Asn Asn Leu His Cys Thr Trp 
785                 790                 795                 800 


Ile Ile Glu Ala Asp Pro Gly Lys Thr Ile Ser Leu His Phe Ile Val 
                805                 810                 815     


Phe Asp Thr Glu Met Ala His Asp Ile Leu Lys Val Trp Asp Gly Pro 
            820                 825                 830         


Val Asp Ser Asp Ile Leu Leu Lys Glu Trp Ser Gly Ser Ala Leu Pro 
        835                 840                 845             


Glu Asp Ile His Ser Thr Phe Asn Ser Leu Thr Leu Gln Phe Asp Ser 
    850                 855                 860                 


Asp Phe Phe Ile Ser Lys Ser Gly Phe Ser Ile Gln Phe Ser Thr Ser 
865                 870                 875                 880 


Ile Ala Ala Thr Cys Asn Asp Pro Gly Met Pro Gln Asn Gly Thr Arg 
                885                 890                 895     


Tyr Gly Asp Ser Arg Glu Ala Gly Asp Thr Val Thr Phe Gln Cys Asp 
            900                 905                 910         


Pro Gly Tyr Gln Leu Gln Gly Gln Ala Lys Ile Thr Cys Val Gln Leu 
        915                 920                 925             


Asn Asn Arg Phe Phe Trp Gln Pro Asp Pro Pro Thr Cys Ile Ala Ala 
    930                 935                 940                 


Cys Gly Gly Asn Leu Thr Gly Pro Ala Gly Val Ile Leu Ser Pro Asn 
945                 950                 955                 960 


Tyr Pro Gln Pro Tyr Pro Pro Gly Lys Glu Cys Asp Trp Arg Val Lys 
                965                 970                 975     


Val Asn Pro Asp Phe Val Ile Ala Leu Ile Phe Lys Ser Phe Asn Met 
            980                 985                 990         


Glu Pro Ser Tyr Asp Phe Leu His  Ile Tyr Glu Gly Glu  Asp Ser Asn 
        995                 1000                 1005             


Ser Pro  Leu Ile Gly Ser Tyr  Gln Gly Ser Gln Ala  Pro Glu Arg 
    1010                 1015                 1020             


Ile Glu  Ser Ser Gly Asn Ser  Leu Phe Leu Ala Phe  Arg Ser Asp 
    1025                 1030                 1035             


Ala Ser  Val Gly Leu Ser Gly  Phe Ala Ile Glu Phe  Lys Glu Lys 
    1040                 1045                 1050             


Pro Arg  Glu Ala Cys Phe Asp  Pro Gly Asn Ile Met  Asn Gly Thr 
    1055                 1060                 1065             


Arg Val  Gly Thr Asp Phe Lys  Leu Gly Ser Thr Ile  Thr Tyr Gln 
    1070                 1075                 1080             


Cys Asp  Ser Gly Tyr Lys Ile  Leu Asp Pro Ser Ser  Ile Thr Cys 
    1085                 1090                 1095             


Val Ile  Gly Ala Asp Gly Lys  Pro Ser Trp Asp Gln  Val Leu Pro 
    1100                 1105                 1110             


Ser Cys  Asn Ala Pro Cys Gly  Gly Gln Tyr Thr Gly  Ser Glu Gly 
    1115                 1120                 1125             


Val Val  Leu Ser Pro Asn Tyr  Pro His Asn Tyr Thr  Ala Gly Gln 
    1130                 1135                 1140             


Ile Cys  Leu Tyr Ser Ile Thr  Val Pro Lys Glu Phe  Val Val Phe 
    1145                 1150                 1155             


Gly Gln  Phe Ala Tyr Phe Gln  Thr Ala Leu Asn Asp  Leu Ala Glu 
    1160                 1165                 1170             


Leu Phe  Asp Gly Thr His Ala  Gln Ala Arg Leu Leu  Ser Ser Leu 
    1175                 1180                 1185             


Ser Gly  Ser His Ser Gly Glu  Thr Leu Pro Leu Ala  Thr Ser Asn 
    1190                 1195                 1200             


Gln Ile  Leu Leu Arg Phe Ser  Ala Lys Ser Gly Ala  Ser Ala Arg 
    1205                 1210                 1215             


Gly Phe  His Phe Val Tyr Gln  Ala Val Pro Arg Thr  Ser Asp Thr 
    1220                 1225                 1230             


Gln Cys  Ser Ser Val Pro Glu  Pro Arg Tyr Gly Arg  Arg Ile Gly 
    1235                 1240                 1245             


Ser Glu  Phe Ser Ala Gly Ser  Ile Val Arg Phe Glu  Cys Asn Pro 
    1250                 1255                 1260             


Gly Tyr  Leu Leu Gln Gly Ser  Thr Ala Leu His Cys  Gln Ser Val 
    1265                 1270                 1275             


Pro Asn  Ala Leu Ala Gln Trp  Asn Asp Thr Ile Pro  Ser Cys Val 
    1280                 1285                 1290             


Val Pro  Cys Ser Gly Asn Phe  Thr Gln Arg Arg Gly  Thr Ile Leu 
    1295                 1300                 1305             


Ser Pro  Gly Tyr Pro Glu Pro  Tyr Gly Asn Asn Leu  Asn Cys Ile 
    1310                 1315                 1320             


Trp Lys  Ile Ile Val Thr Glu  Gly Ser Gly Ile Gln  Ile Gln Val 
    1325                 1330                 1335             


Ile Ser  Phe Ala Thr Glu Gln  Asn Trp Asp Ser Leu  Glu Ile His 
    1340                 1345                 1350             


Asp Gly  Gly Asp Val Thr Ala  Pro Arg Leu Gly Ser  Phe Ser Gly 
    1355                 1360                 1365             


Thr Thr  Val Pro Ala Leu Leu  Asn Ser Thr Ser Asn  Gln Leu Tyr 
    1370                 1375                 1380             


Leu His  Phe Gln Ser Asp Ile  Ser Val Ala Ala Ala  Gly Phe His 
    1385                 1390                 1395             


Leu Glu  Tyr Lys Thr Val Gly  Leu Ala Ala Cys Gln  Glu Pro Ala 
    1400                 1405                 1410             


Leu Pro  Ser Asn Ser Ile Lys  Ile Gly Asp Arg Tyr  Met Val Asn 
    1415                 1420                 1425             


Asp Val  Leu Ser Phe Gln Cys  Glu Pro Gly Tyr Thr  Leu Gln Gly 
    1430                 1435                 1440             


Arg Ser  His Ile Ser Cys Met  Pro Gly Thr Val Arg  Arg Trp Asn 
    1445                 1450                 1455             


Tyr Pro  Ser Pro Leu Cys Ile  Ala Thr Cys Gly Gly  Thr Leu Ser 
    1460                 1465                 1470             


Thr Leu  Gly Gly Val Ile Leu  Ser Pro Gly Phe Pro  Gly Ser Tyr 
    1475                 1480                 1485             


Pro Asn  Asn Leu Asp Cys Thr  Trp Arg Ile Ser Leu  Pro Ile Gly 
    1490                 1495                 1500             


Tyr Gly  Ala His Ile Gln Phe  Leu Asn Phe Ser Thr  Glu Ala Asn 
    1505                 1510                 1515             


His Asp  Phe Leu Glu Ile Gln  Asn Gly Pro Tyr His  Thr Ser Pro 
    1520                 1525                 1530             


Met Ile  Gly Gln Phe Ser Gly  Thr Asp Leu Pro Ala  Ala Leu Leu 
    1535                 1540                 1545             


Ser Thr  Thr His Glu Thr Leu  Ile His Phe Tyr Ser  Asp His Ser 
    1550                 1555                 1560             


Gln Asn  Arg Gln Gly Phe Lys  Leu Ala Tyr Gln Ala  Tyr Glu Leu 
    1565                 1570                 1575             


Gln Asn  Cys Pro Asp Pro Pro  Pro Phe Gln Asn Gly  Tyr Met Ile 
    1580                 1585                 1590             


Asn Ser  Asp Tyr Ser Val Gly  Gln Ser Val Ser Phe  Glu Cys Tyr 
    1595                 1600                 1605             


Pro Gly  Tyr Ile Leu Ile Gly  His Pro Val Leu Thr  Cys Gln His 
    1610                 1615                 1620             


Gly Ile  Asn Arg Asn Trp Asn  Tyr Pro Phe Pro Arg  Cys Asp Ala 
    1625                 1630                 1635             


Pro Cys  Gly Tyr Asn Val Thr  Ser Gln Asn Gly Thr  Ile Tyr Ser 
    1640                 1645                 1650             


Pro Gly  Phe Pro Asp Glu Tyr  Pro Ile Leu Lys Asp  Cys Ile Trp 
    1655                 1660                 1665             


Leu Ile  Thr Val Pro Pro Gly  His Gly Val Tyr Ile  Asn Phe Thr 
    1670                 1675                 1680             


Leu Leu  Gln Thr Glu Ala Val  Asn Asp Tyr Ile Ala  Val Trp Asp 
    1685                 1690                 1695             


Gly Pro  Asp Gln Asn Ser Pro  Gln Leu Gly Val Phe  Ser Gly Asn 
    1700                 1705                 1710             


Thr Ala  Leu Glu Thr Ala Tyr  Ser Ser Thr Asn Gln  Val Leu Leu 
    1715                 1720                 1725             


Lys Phe  His Ser Asp Phe Ser  Asn Gly Gly Phe Phe  Val Leu Asn 
    1730                 1735                 1740             


Phe His  Ala Phe Gln Leu Lys  Lys Cys Gln Pro Pro  Pro Ala Val 
    1745                 1750                 1755             


Pro Gln  Ala Glu Met Leu Thr  Glu Asp Asp Asp Phe  Glu Ile Gly 
    1760                 1765                 1770             


Asp Phe  Val Lys Tyr Gln Cys  His Pro Gly Tyr Thr  Leu Val Gly 
    1775                 1780                 1785             


Thr Asp  Ile Leu Thr Cys Lys  Leu Ser Ser Gln Leu  Gln Phe Glu 
    1790                 1795                 1800             


Gly Ser  Leu Pro Thr Cys Glu  Ala Gln Cys Pro Ala  Asn Glu Val 
    1805                 1810                 1815             


Arg Thr  Gly Ser Ser Gly Val  Ile Leu Ser Pro Gly  Tyr Pro Gly 
    1820                 1825                 1830             


Asn Tyr  Phe Asn Ser Gln Thr  Cys Ser Trp Ser Ile  Lys Val Glu 
    1835                 1840                 1845             


Pro Asn  Tyr Asn Ile Thr Ile  Phe Val Asp Thr Phe  Gln Ser Glu 
    1850                 1855                 1860             


Lys Gln  Phe Asp Ala Leu Glu  Val Phe Asp Gly Ser  Ser Gly Gln 
    1865                 1870                 1875             


Ser Pro  Leu Leu Val Val Leu  Ser Gly Asn His Thr  Glu Gln Ser 
    1880                 1885                 1890             


Asn Phe  Thr Ser Arg Ser Asn  Gln Leu Tyr Leu Arg  Trp Ser Thr 
    1895                 1900                 1905             


Asp His  Ala Thr Ser Lys Lys  Gly Phe Lys Ile Arg  Tyr Ala Ala 
    1910                 1915                 1920             


Pro Tyr  Cys Ser Leu Thr His  Pro Leu Lys Asn Gly  Gly Ile Leu 
    1925                 1930                 1935             


Asn Arg  Thr Ala Gly Ala Val  Gly Ser Lys Val His  Tyr Phe Cys 
    1940                 1945                 1950             


Lys Pro  Gly Tyr Arg Met Val  Gly His Ser Asn Ala  Thr Cys Arg 
    1955                 1960                 1965             


Arg Asn  Pro Leu Gly Met Tyr  Gln Trp Asp Ser Leu  Thr Pro Leu 
    1970                 1975                 1980             


Cys Gln  Ala Val Ser Cys Gly  Ile Pro Glu Ser Pro  Gly Asn Gly 
    1985                 1990                 1995             


Ser Phe  Thr Gly Asn Glu Phe  Thr Leu Asp Ser Lys  Val Val Tyr 
    2000                 2005                 2010             


Glu Cys  His Glu Gly Phe Lys  Leu Glu Ser Ser Gln  Gln Ala Thr 
    2015                 2020                 2025             


Ala Val  Cys Gln Glu Asp Gly  Leu Trp Ser Asn Lys  Gly Lys Pro 
    2030                 2035                 2040             


Pro Thr  Cys Lys Pro Val Ala  Cys Pro Ser Ile Glu  Ala Gln Leu 
    2045                 2050                 2055             


Ser Glu  His Val Ile Trp Arg  Leu Val Ser Gly Ser  Leu Asn Glu 
    2060                 2065                 2070             


Tyr Gly  Ala Gln Val Leu Leu  Ser Cys Ser Pro Gly  Tyr Tyr Leu 
    2075                 2080                 2085             


Glu Gly  Trp Arg Leu Leu Arg  Cys Gln Ala Asn Gly  Thr Trp Asn 
    2090                 2095                 2100             


Ile Gly  Asp Glu Arg Pro Ser  Cys Arg Val Ile Ser  Cys Gly Ser 
    2105                 2110                 2115             


Leu Ser  Phe Pro Pro Asn Gly  Asn Lys Ile Gly Thr  Leu Thr Val 
    2120                 2125                 2130             


Tyr Gly  Ala Thr Ala Ile Phe  Thr Cys Asn Thr Gly  Tyr Thr Leu 
    2135                 2140                 2145             


Val Gly  Ser His Val Arg Glu  Cys Leu Ala Asn Gly  Leu Trp Ser 
    2150                 2155                 2160             


Gly Ser  Glu Thr Arg Cys Leu  Ala Gly His Cys Gly  Ser Pro Asp 
    2165                 2170                 2175             


Pro Ile  Val Asn Gly His Ile  Ser Gly Asp Gly Phe  Ser Tyr Arg 
    2180                 2185                 2190             


Asp Thr  Val Val Tyr Gln Cys  Asn Pro Gly Phe Arg  Leu Val Gly 
    2195                 2200                 2205             


Thr Ser  Val Arg Ile Cys Leu  Gln Asp His Lys Trp  Ser Gly Gln 
    2210                 2215                 2220             


Thr Pro  Val Cys Val Pro Ile  Thr Cys Gly His Pro  Gly Asn Pro 
    2225                 2230                 2235             


Ala His  Gly Phe Thr Asn Gly  Ser Glu Phe Asn Leu  Asn Asp Val 
    2240                 2245                 2250             


Val Asn  Phe Thr Cys Asn Thr  Gly Tyr Leu Leu Gln  Gly Val Ser 
    2255                 2260                 2265             


Arg Ala  Gln Cys Arg Ser Asn  Gly Gln Trp Ser Ser  Pro Leu Pro 
    2270                 2275                 2280             


Thr Cys  Arg Val Val Asn Cys  Ser Asp Pro Gly Phe  Val Glu Asn 
    2285                 2290                 2295             


Ala Ile  Arg His Gly Gln Gln  Asn Phe Pro Glu Ser  Phe Glu Tyr 
    2300                 2305                 2310             


Gly Met  Ser Ile Leu Tyr His  Cys Lys Lys Gly Phe  Tyr Leu Leu 
    2315                 2320                 2325             


Gly Ser  Ser Ala Leu Thr Cys  Met Ala Asn Gly Leu  Trp Asp Arg 
    2330                 2335                 2340             


Ser Leu  Pro Lys Cys Leu Ala  Ile Ser Cys Gly His  Pro Gly Val 
    2345                 2350                 2355             


Pro Ala  Asn Ala Val Leu Thr  Gly Glu Leu Phe Thr  Tyr Gly Ala 
    2360                 2365                 2370             


Val Val  His Tyr Ser Cys Arg  Gly Ser Glu Ser Leu  Ile Gly Asn 
    2375                 2380                 2385             


Asp Thr  Arg Val Cys Gln Glu  Asp Ser His Trp Ser  Gly Ala Leu 
    2390                 2395                 2400             


Pro His  Cys Thr Gly Asn Asn  Pro Gly Phe Cys Gly  Asp Pro Gly 
    2405                 2410                 2415             


Thr Pro  Ala His Gly Ser Arg  Leu Gly Asp Asp Phe  Lys Thr Lys 
    2420                 2425                 2430             


Ser Leu  Leu Arg Phe Ser Cys  Glu Met Gly His Gln  Leu Arg Gly 
    2435                 2440                 2445             


Ser Pro  Glu Arg Thr Cys Leu  Leu Asn Gly Ser Trp  Ser Gly Leu 
    2450                 2455                 2460             


Gln Pro  Val Cys Glu Ala Val  Ser Cys Gly Asn Pro  Gly Thr Pro 
    2465                 2470                 2475             


Thr Asn  Gly Met Ile Val Ser  Ser Asp Gly Ile Leu  Phe Ser Ser 
    2480                 2485                 2490             


Ser Val  Ile Tyr Ala Cys Trp  Glu Gly Tyr Lys Thr  Ser Gly Leu 
    2495                 2500                 2505             


Met Thr  Arg His Cys Thr Ala  Asn Gly Thr Trp Thr  Gly Thr Ala 
    2510                 2515                 2520             


Pro Asp  Cys Thr Ile Ile Ser  Cys Gly Asp Pro Gly  Thr Leu Ala 
    2525                 2530                 2535             


Asn Gly  Ile Gln Phe Gly Thr  Asp Phe Thr Phe Asn  Lys Thr Val 
    2540                 2545                 2550             


Ser Tyr  Gln Cys Asn Pro Gly  Tyr Val Met Glu Ala  Val Thr Ser 
    2555                 2560                 2565             


Ala Thr  Ile Arg Cys Thr Lys  Asp Gly Arg Trp Asn  Pro Ser Lys 
    2570                 2575                 2580             


Pro Val  Cys Lys Ala Val Leu  Cys Pro Gln Pro Pro  Pro Val Gln 
    2585                 2590                 2595             


Asn Gly  Thr Val Glu Gly Ser  Asp Phe Arg Trp Gly  Ser Ser Ile 
    2600                 2605                 2610             


Ser Tyr  Ser Cys Met Asp Gly  Tyr Gln Leu Ser His  Ser Ala Ile 
    2615                 2620                 2625             


Leu Ser  Cys Glu Gly Arg Gly  Val Trp Lys Gly Glu  Ile Pro Gln 
    2630                 2635                 2640             


Cys Leu  Pro Val Phe Cys Gly  Asp Pro Gly Ile Pro  Ala Glu Gly 
    2645                 2650                 2655             


Arg Leu  Ser Gly Lys Ser Phe  Thr Tyr Lys Ser Glu  Val Phe Phe 
    2660                 2665                 2670             


Gln Cys  Lys Ser Pro Phe Ile  Leu Val Gly Ser Ser  Arg Arg Val 
    2675                 2680                 2685             


Cys Gln  Ala Asp Gly Thr Trp  Ser Gly Ile Gln Pro  Thr Cys Ile 
    2690                 2695                 2700             


Asp Pro  Ala His Asn Thr Cys  Pro Asp Pro Gly Thr  Pro His Phe 
    2705                 2710                 2715             


Gly Ile  Gln Asn Ser Ser Arg  Gly Tyr Glu Val Gly  Ser Thr Val 
    2720                 2725                 2730             


Phe Phe  Arg Cys Arg Lys Gly  Tyr His Ile Gln Gly  Ser Thr Thr 
    2735                 2740                 2745             


Arg Thr  Cys Leu Ala Asn Leu  Thr Trp Ser Gly Ile  Gln Thr Glu 
    2750                 2755                 2760             


Cys Ile  Pro His Ala Cys Arg  Gln Pro Glu Thr Pro  Ala His Ala 
    2765                 2770                 2775             


Asp Val  Arg Ala Ile Asp Leu  Pro Thr Phe Gly Tyr  Thr Leu Val 
    2780                 2785                 2790             


Tyr Thr  Cys His Pro Gly Phe  Phe Leu Ala Gly Gly  Ser Glu His 
    2795                 2800                 2805             


Arg Thr  Cys Lys Ala Asp Met  Lys Trp Thr Gly Lys  Ser Pro Val 
    2810                 2815                 2820             


Cys Lys  Ser Lys Gly Val Arg  Glu Val Asn Glu Thr  Val Thr Lys 
    2825                 2830                 2835             


Thr Pro  Val Pro Ser Asp Val  Phe Phe Val Asn Ser  Leu Trp Lys 
    2840                 2845                 2850             


Gly Tyr  Tyr Glu Tyr Leu Gly  Lys Arg Gln Pro Ala  Thr Leu Thr 
    2855                 2860                 2865             


Val Asp  Trp Phe Asn Ala Thr  Ser Ser Lys Val Asn  Ala Thr Phe 
    2870                 2875                 2880             


Ser Glu  Ala Ser Pro Val Glu  Leu Lys Leu Thr Gly  Ile Tyr Lys 
    2885                 2890                 2895             


Lys Glu  Glu Ala His Leu Leu  Leu Lys Ala Phe Gln  Ile Lys Gly 
    2900                 2905                 2910             


Gln Ala  Asp Ile Phe Val Ser  Lys Phe Glu Asn Asp  Asn Trp Gly 
    2915                 2920                 2925             


Leu Asp  Gly Tyr Val Ser Ser  Gly Leu Glu Arg Gly  Gly Phe Thr 
    2930                 2935                 2940             


Phe Gln  Gly Asp Ile His Gly  Lys Asp Phe Gly Lys  Phe Lys Leu 
    2945                 2950                 2955             


Glu Arg  Gln Asp Pro Leu Asn  Pro Asp Gln Asp Ser  Ser Ser His 
    2960                 2965                 2970             


Tyr His  Gly Thr Ser Ser Gly  Ser Val Ala Ala Ala  Ile Leu Val 
    2975                 2980                 2985             


Pro Phe  Phe Ala Leu Ile Leu  Ser Gly Phe Ala Phe  Tyr Leu Tyr 
    2990                 2995                 3000             


Lys His  Arg Thr Arg Pro Lys  Val Gln Tyr Asn Gly  Tyr Ala Gly 
    3005                 3010                 3015             


His Glu  Asn Ser Asn Gly Gln  Ala Ser Phe Glu Asn  Pro Met Tyr 
    3020                 3025                 3030             


Asp Thr  Asn Leu Lys Pro Thr  Glu Ala Lys Ala Val  Arg Phe Asp 
    3035                 3040                 3045             


Thr Thr  Leu Asn Thr Val Cys  Thr Val Val 
    3050                 3055             

<210>  2434
<211>  406
<212>  DNA
<213>  Homo sapiens

<400>  2434
agctgaggga gcctgcggag gaaccttacg cgggaccagc agctccatct ccagcccgca     60

cttcccttca gagtacgaga acaacgcgga ctgcacctgg accattctgg ctgagcccgg    120

ggacaccatt gcgctggtct tcactgactt tcagctagaa gaaggatatg atttcttaga    180

gatcagtggc acggaagctc catccatatg gctaactggc atgaacctcc cctctccagt    240

tatcagtagc aagaattggc tacgactcca tttcacctct gacagcaacc accgacgcaa    300

aggatttaac gctcagttcc aagtgaaaaa ggcgattgag ttgaagtcaa gaggagtcaa    360

gatgctgccc agcaaggatg gaagccataa aaactctgtc tgtgag                   406


<210>  2435
<211>  61
<212>  PRT
<213>  Homo sapiens

<400>  2435


Met Asn Leu Pro Ser Pro Val Ile Ser Ser Lys Asn Trp Leu Arg Leu 
1               5                   10                  15      


His Phe Thr Ser Asp Ser Asn His Arg Arg Lys Gly Phe Asn Ala Gln 
            20                  25                  30          


Phe Gln Val Lys Lys Ala Ile Glu Leu Lys Ser Arg Gly Val Lys Met 
        35                  40                  45              


Leu Pro Ser Lys Asp Gly Ser His Lys Asn Ser Val Cys 
    50                  55                  60      

<210>  2436
<211>  1535
<212>  DNA
<213>  Homo sapiens

<400>  2436
gaactcgccg ggccacaccc cctgtccagg gaaggaacac gcccccggtg acagccggta     60

cggccccggg tttgggcaac ctcgattacg ggcggcctcc agccccgcca gcagcgcccc    120

gcgcccgccc gcccgcgccc ctgccgcccc ccggttccgg ccgcggaccc cactctctgc    180

cgttccggct gcggctccgc tgccggtagc gccgtccccc gggaccaccc ttcggctggc    240

gccctcccat gctctcggcc acccggaggg cttgccagct cctcctcctc cacagcctct    300

ttcccgtccc gaggatgggc aactcggcct cgaacatcgt cagcccccag gaggccttgc    360

cgggccggaa ggaacagacc cctgtagcgg ccaaacatca tgtcaatggc aacagaacag    420

tcgaaccttt cccagaggga acacagatgg ctgtatttgg aatgggatgt ttctggggag    480

ctgaaaggaa attctgggtc ttgaaaggag tgtattcaac tcaagttggt tttgcaggag    540

gctatacttc aaatcctact tataaagaag tctgctcaga aaaaactggc catgcagaag    600

tcgtccgagt ggtgtaccag ccagaacaca tgagttttga ggaactgctc aaggtcttct    660

gggagaatca cgacccgacc caaggtatgc gccaggggaa cgaccatggc actcagtacc    720

gctcggccat ctacccgacc tctgccaagc aaatggaggc agccctgagc tccaaagaga    780

actaccaaaa ggttctttca gagcacggct tcggccccat cactaccgac atccgggagg    840

gacagacttt ctactatgcg gaagactacc accagcagta cctgagcaag aaccccaatg    900

gctactgcgg ccttgggggc accggcgtgt cctgcccagt gggtattaaa aaataatttc    960

tccccacatg gtgggccttt gaggttccag taaaaatgct ttcaacaaat tgggcaatgc   1020

ttgtgtgatt cacaatcgtg gcatttaaag tgcacaaagt acaaaggaat ttatacagat   1080

tgggtttacc gaagtataat ctataggagg cgcgatggca agttgataaa atgtgactta   1140

tctcctaata agttatggtg ggagtggagc tgtgcagttt cctgtgtctt ctggggtctg   1200

agtgaagata gcagggatgc tgtgttcacc cttcttggta gaagctaagg tgtgagctgg   1260

gaggttgctg gacaggatgg gggaccccag aagtccttta tctgtgctct ctgcccgcca   1320

gtgccttaca atttgcaaac gtgtatagcc tcagtgactc attcgctgaa atccttcgct   1380

ttaccaaatc tagacataca taaggggctt tctctccctt ttcagccctc tctgtgcaga   1440

gaaaagatgt gagtccgctt gatgaattct aatgctttgc ttagagctat gagaaatgtt   1500

tgttttaata aaaacctaca gtccaataat gccaa                              1535


<210>  2437
<211>  235
<212>  PRT
<213>  Homo sapiens

<400>  2437


Met Leu Ser Ala Thr Arg Arg Ala Cys Gln Leu Leu Leu Leu His Ser 
1               5                   10                  15      


Leu Phe Pro Val Pro Arg Met Gly Asn Ser Ala Ser Asn Ile Val Ser 
            20                  25                  30          


Pro Gln Glu Ala Leu Pro Gly Arg Lys Glu Gln Thr Pro Val Ala Ala 
        35                  40                  45              


Lys His His Val Asn Gly Asn Arg Thr Val Glu Pro Phe Pro Glu Gly 
    50                  55                  60                  


Thr Gln Met Ala Val Phe Gly Met Gly Cys Phe Trp Gly Ala Glu Arg 
65                  70                  75                  80  


Lys Phe Trp Val Leu Lys Gly Val Tyr Ser Thr Gln Val Gly Phe Ala 
                85                  90                  95      


Gly Gly Tyr Thr Ser Asn Pro Thr Tyr Lys Glu Val Cys Ser Glu Lys 
            100                 105                 110         


Thr Gly His Ala Glu Val Val Arg Val Val Tyr Gln Pro Glu His Met 
        115                 120                 125             


Ser Phe Glu Glu Leu Leu Lys Val Phe Trp Glu Asn His Asp Pro Thr 
    130                 135                 140                 


Gln Gly Met Arg Gln Gly Asn Asp His Gly Thr Gln Tyr Arg Ser Ala 
145                 150                 155                 160 


Ile Tyr Pro Thr Ser Ala Lys Gln Met Glu Ala Ala Leu Ser Ser Lys 
                165                 170                 175     


Glu Asn Tyr Gln Lys Val Leu Ser Glu His Gly Phe Gly Pro Ile Thr 
            180                 185                 190         


Thr Asp Ile Arg Glu Gly Gln Thr Phe Tyr Tyr Ala Glu Asp Tyr His 
        195                 200                 205             


Gln Gln Tyr Leu Ser Lys Asn Pro Asn Gly Tyr Cys Gly Leu Gly Gly 
    210                 215                 220                 


Thr Gly Val Ser Cys Pro Val Gly Ile Lys Lys 
225                 230                 235 

<210>  2438
<211>  889
<212>  DNA
<213>  Homo sapiens

<400>  2438
cgccgggcca caccccctgt ccagggaagg aacacgcccc cggtgacagc cggtacggcc     60

ccgggtttgg gcaacctcga ttacgggcgg cctccagccc cgccagcagc gccccgcgcc    120

cgcccgcccg cgcccctgcc gccccccggt tccggccgcg gaccccactc tctgccgttc    180

cggctgcggc tccgctgccg gtagcgccgt cccccgggac cacccttcgg ctggcgccct    240

cccatgctct cggccacccg gagggcttgc cagctcctcc tcctccacag cctctttccc    300

gtcccgagga tgggcaactc ggcctcgaac atcgtcagcc cccaggaggc cttgccgggc    360

cggaaggaac agacccctgt agcggccaaa catcatgtca atggcaacag aacagtcgaa    420

cctttcccag agggaacaca gatggctgta tttgaaaaaa ctggccatgc agaagtcgtc    480

cgagtggtgt accagccaga acacatgagt tttgaggaac tgctcaaggt cttctgggag    540

aatcacgacc cgacccaagg tatgcgccag gggaacgacc atggcactca gtaccgctcg    600

gccatctacc cgacctctgc caagcaaatg gaggcagccc tgagctccaa agagaactac    660

caaaaggttc tttcagagca cggcttcggc cccatcacta ccgacatccg ggagggacag    720

actttctact atgcggaaga ctaccaccag cagtacctga gcaagaaccc caatggctac    780

tgcggccttg ggggcaccgg cgtgtcctgc ccagtgggta ttaaaaaata atttctcccc    840

acatggtggg cctttgaggt tccagtaaaa atgctttcaa caaattggg                889


<210>  2439
<211>  195
<212>  PRT
<213>  Homo sapiens

<400>  2439


Met Leu Ser Ala Thr Arg Arg Ala Cys Gln Leu Leu Leu Leu His Ser 
1               5                   10                  15      


Leu Phe Pro Val Pro Arg Met Gly Asn Ser Ala Ser Asn Ile Val Ser 
            20                  25                  30          


Pro Gln Glu Ala Leu Pro Gly Arg Lys Glu Gln Thr Pro Val Ala Ala 
        35                  40                  45              


Lys His His Val Asn Gly Asn Arg Thr Val Glu Pro Phe Pro Glu Gly 
    50                  55                  60                  


Thr Gln Met Ala Val Phe Glu Lys Thr Gly His Ala Glu Val Val Arg 
65                  70                  75                  80  


Val Val Tyr Gln Pro Glu His Met Ser Phe Glu Glu Leu Leu Lys Val 
                85                  90                  95      


Phe Trp Glu Asn His Asp Pro Thr Gln Gly Met Arg Gln Gly Asn Asp 
            100                 105                 110         


His Gly Thr Gln Tyr Arg Ser Ala Ile Tyr Pro Thr Ser Ala Lys Gln 
        115                 120                 125             


Met Glu Ala Ala Leu Ser Ser Lys Glu Asn Tyr Gln Lys Val Leu Ser 
    130                 135                 140                 


Glu His Gly Phe Gly Pro Ile Thr Thr Asp Ile Arg Glu Gly Gln Thr 
145                 150                 155                 160 


Phe Tyr Tyr Ala Glu Asp Tyr His Gln Gln Tyr Leu Ser Lys Asn Pro 
                165                 170                 175     


Asn Gly Tyr Cys Gly Leu Gly Gly Thr Gly Val Ser Cys Pro Val Gly 
            180                 185                 190         


Ile Lys Lys 
        195 

<210>  2440
<211>  1009
<212>  DNA
<213>  Homo sapiens

<400>  2440
cgccgggcca caccccctgt ccagggaagg aacacgcccc cggtgacagc cggtacggcc     60

ccgggtttgg gcaacctcga ttacgggcgg cctccagccc cgccagcagc gccccgcgcc    120

cgcccgcccg cgcccctgcc gccccccggt tccggccgcg gaccccactc tctgccgttc    180

cggctgcggc tccgctgccg gtagcgccgt cccccgggac cacccttcgg ctggcgccct    240

cccatgctct cggccacccg gagggcttgc cagctcctcc tcctccacag cctctttccc    300

gtcccgagga tgggcaactc ggcctcgaac atcgtcagcc cccaggaggc cttgccgggc    360

cggaaggaac agacccctgt agcggccaaa catcatgtca atggcaacag aacagtcgaa    420

cctttcccag agggaacaca gatggctgta tttggaatgg gatgtttctg gggagctgaa    480

aggaaattct gggtcttgaa aggagtgtat tcaactcaag ttggttttgc aggaggctat    540

acttcaaatc ctacttataa agaagtctgc tcagaaaaaa ctggccatgc agaagtcgtc    600

cgagtggtgt accagccaga acacatgagt tttgaggaac tgctcaaggt cttctgggag    660

aatcacgacc cgacccaagg tatgcgccag gggaacgacc atggcactca gtaccgctcg    720

gccatctacc cgacctctgc caagcaaatg gaggcagccc tgagctccaa agagaactac    780

caaaaggttc tttcagagca cggcttcggc cccatcacta ccgacatccg ggagggacag    840

actttctact atgcggaaga ctaccaccag cagtacctga gcaagaaccc caatggctac    900

tgcggccttg ggggcaccgg cgtgtcctgc ccagtgggta ttaaaaaata atttctcccc    960

acatggtggg cctttgaggt tccagtaaaa atgctttcaa caaattggg               1009


<210>  2441
<211>  235
<212>  PRT
<213>  Homo sapiens

<400>  2441


Met Leu Ser Ala Thr Arg Arg Ala Cys Gln Leu Leu Leu Leu His Ser 
1               5                   10                  15      


Leu Phe Pro Val Pro Arg Met Gly Asn Ser Ala Ser Asn Ile Val Ser 
            20                  25                  30          


Pro Gln Glu Ala Leu Pro Gly Arg Lys Glu Gln Thr Pro Val Ala Ala 
        35                  40                  45              


Lys His His Val Asn Gly Asn Arg Thr Val Glu Pro Phe Pro Glu Gly 
    50                  55                  60                  


Thr Gln Met Ala Val Phe Gly Met Gly Cys Phe Trp Gly Ala Glu Arg 
65                  70                  75                  80  


Lys Phe Trp Val Leu Lys Gly Val Tyr Ser Thr Gln Val Gly Phe Ala 
                85                  90                  95      


Gly Gly Tyr Thr Ser Asn Pro Thr Tyr Lys Glu Val Cys Ser Glu Lys 
            100                 105                 110         


Thr Gly His Ala Glu Val Val Arg Val Val Tyr Gln Pro Glu His Met 
        115                 120                 125             


Ser Phe Glu Glu Leu Leu Lys Val Phe Trp Glu Asn His Asp Pro Thr 
    130                 135                 140                 


Gln Gly Met Arg Gln Gly Asn Asp His Gly Thr Gln Tyr Arg Ser Ala 
145                 150                 155                 160 


Ile Tyr Pro Thr Ser Ala Lys Gln Met Glu Ala Ala Leu Ser Ser Lys 
                165                 170                 175     


Glu Asn Tyr Gln Lys Val Leu Ser Glu His Gly Phe Gly Pro Ile Thr 
            180                 185                 190         


Thr Asp Ile Arg Glu Gly Gln Thr Phe Tyr Tyr Ala Glu Asp Tyr His 
        195                 200                 205             


Gln Gln Tyr Leu Ser Lys Asn Pro Asn Gly Tyr Cys Gly Leu Gly Gly 
    210                 215                 220                 


Thr Gly Val Ser Cys Pro Val Gly Ile Lys Lys 
225                 230                 235 

<210>  2442
<211>  1410
<212>  DNA
<213>  Homo sapiens

<400>  2442
cgccgggcca caccccctgt ccagggaagg aacacgcccc cggtgacagc cggtacggcc     60

ccgggtttgg gcaacctcga ttacgggcgg cctccagccc cgccagcagc gccccgcgcc    120

cgcccgcccg cgcccctgcc gccccccggt tccggccgcg gaccccactc tctgccgttc    180

cggctgcggc tccgctgccg gtagcgccgt cccccgggac cacccttcgg ctggcgccct    240

cccatgctct cggccacccg gagggcttgc cagctcctcc tcctccacag cctctttccc    300

gtcccgagga tgggcaactc ggcctcgaac atcgtcagcc cccaggaggc cttgccgggc    360

cggaaggaac agacccctgt agcggccaaa catcatgtca atggcaacag aacagtcgaa    420

cctttcccag agggaacaca gatggctgta tttgaaaaaa ctggccatgc agaagtcgtc    480

cgagtggtgt accagccaga acacatgagt tttgaggaac tgctcaaggt cttctgggag    540

aatcacgacc cgacccaagg tatgcgccag gggaacgacc atggcactca gtaccgctcg    600

gccatctacc cgacctctgc caagcaaatg gaggcagccc tgagctccaa agagaactac    660

caaaaggttc tttcagagca cggcttcggc cccatcacta ccgacatccg ggagggacag    720

actttctact atgcggaaga ctaccaccag cagtacctga gcaagaaccc caatggctac    780

tgcggccttg ggggcaccgg cgtgtcctgc ccagtgggta ttaaaaaata atttctcccc    840

acatggtggg cctttgaggt tccagtaaaa atgctttcaa caaattgggc aatgcttgtg    900

tgattcacaa tcgtggcatt taaagtgcac aaagtacaaa ggaatttata cagattgggt    960

ttaccgaagt ataatctata ggaggcgcga tggcaagttg ataaaatgtg acttatctcc   1020

taataagtta tggtgggagt ggagctgtgc agtttcctgt gtcttctggg gtctgagtga   1080

agatagcagg gatgctgtgt tcacccttct tggtagaagc taaggtgtga gctgggaggt   1140

tgctggacag gatgggggac cccagaagtc ctttatctgt gctctctgcc cgccagtgcc   1200

ttacaatttg caaacgtgta tagcctcagt gactcattcg ctgaaatcct tcgctttacc   1260

aaatctagac atacataagg ggctttctct cccttttcag ccctctctgt gcagagaaaa   1320

gatgtgagtc cgcttgatga attctaatgc tttgcttaga gctatgagaa atgtttgttt   1380

taataaaaac ctacagtcca ataatgccaa                                    1410


<210>  2443
<211>  195
<212>  PRT
<213>  Homo sapiens

<400>  2443


Met Leu Ser Ala Thr Arg Arg Ala Cys Gln Leu Leu Leu Leu His Ser 
1               5                   10                  15      


Leu Phe Pro Val Pro Arg Met Gly Asn Ser Ala Ser Asn Ile Val Ser 
            20                  25                  30          


Pro Gln Glu Ala Leu Pro Gly Arg Lys Glu Gln Thr Pro Val Ala Ala 
        35                  40                  45              


Lys His His Val Asn Gly Asn Arg Thr Val Glu Pro Phe Pro Glu Gly 
    50                  55                  60                  


Thr Gln Met Ala Val Phe Glu Lys Thr Gly His Ala Glu Val Val Arg 
65                  70                  75                  80  


Val Val Tyr Gln Pro Glu His Met Ser Phe Glu Glu Leu Leu Lys Val 
                85                  90                  95      


Phe Trp Glu Asn His Asp Pro Thr Gln Gly Met Arg Gln Gly Asn Asp 
            100                 105                 110         


His Gly Thr Gln Tyr Arg Ser Ala Ile Tyr Pro Thr Ser Ala Lys Gln 
        115                 120                 125             


Met Glu Ala Ala Leu Ser Ser Lys Glu Asn Tyr Gln Lys Val Leu Ser 
    130                 135                 140                 


Glu His Gly Phe Gly Pro Ile Thr Thr Asp Ile Arg Glu Gly Gln Thr 
145                 150                 155                 160 


Phe Tyr Tyr Ala Glu Asp Tyr His Gln Gln Tyr Leu Ser Lys Asn Pro 
                165                 170                 175     


Asn Gly Tyr Cys Gly Leu Gly Gly Thr Gly Val Ser Cys Pro Val Gly 
            180                 185                 190         


Ile Lys Lys 
        195 

<210>  2444
<211>  808
<212>  DNA
<213>  Homo sapiens

<400>  2444
attattattt tacattgtag gtacagccag tgtgatcaga caaagcaatt cgagaactac     60

aaaagaggaa aaaagatcag aagttcttaa atacataagg gaatgcagca tttgataaag    120

ccaaacatca tgtcaatggc aacagaacag tcgaaccttt cccagaggga acacagatgg    180

ctgtatttgg aatgggatgt ttctggggag ctgaaaggaa attctgggtc ttgaaaggag    240

tgtattcaac tcaagttggt tttgcaggag gctatacttc aaatcctact tataaagaag    300

tctgctcaga tgttcagaac aattccatgt ttattagtct attcaaaagc ttttagaaat    360

ctgcacagcc aagtggcact gaatccagaa gcatgaaagg agctgcacaa cttttcctcg    420

taagatttac acaagcagca cgggaaatct gaggcccaga catttcctta tcaacagaat    480

actccggtgg attttcaagc aggctgttca gcagaggttt cgagcaggag cccaggtgtg    540

ggaagagcgg agtgtgggag tcctcgtgtg accctctggg ggtggtgatg gaactgactg    600

tatggtctgc aaaacctaaa atatttactg tcaggtgctt atgtgtcctg tcctgagccc    660

gtttcctctc ttgtaaaatg gggcaatgct gcttgatgaa accagtcaag ttgtggttgg    720

attcttatat gtaataaacc tgcacattgt gcacatatac cctaaaactt aaagtatgat    780

aaaaataaaa aaaattgttg caaatctg                                       808


<210>  2445
<211>  59
<212>  PRT
<213>  Homo sapiens

<400>  2445


Met Ala Val Phe Gly Met Gly Cys Phe Trp Gly Ala Glu Arg Lys Phe 
1               5                   10                  15      


Trp Val Leu Lys Gly Val Tyr Ser Thr Gln Val Gly Phe Ala Gly Gly 
            20                  25                  30          


Tyr Thr Ser Asn Pro Thr Tyr Lys Glu Val Cys Ser Asp Val Gln Asn 
        35                  40                  45              


Asn Ser Met Phe Ile Ser Leu Phe Lys Ser Phe 
    50                  55                  

<210>  2446
<211>  1633
<212>  DNA
<213>  Homo sapiens

<400>  2446
gagagagaga aagagggaga gagagaggca gagggagagc tgaggaaaga aaaaaaggca     60

agacttggca cagctcagtc aaatcagctt cttttgtctg ctttctcggc ttgagcttca    120

ggaaagaaaa ccgtcctggg gtacagaaaa actcagaact ttttggtttt caaacttaga    180

aggcttttta agtctcttgg gctatttgaa agtgttggta catacaatga cgtttagtca    240

ccagtattaa gggaaataaa agcctttttc aaaacgaagc ttccatagtg tccatgcatt    300

tgggaaatac tatatttgat tttttgcatg tatgattata ccatgagaga caggattaat    360

atagaagatg gcaaggcaaa tttctaatta gagggaatat taattttcta caaaataaag    420

tttgttcatc aatacaaacc tgctttcaaa tcaaatcaga aagacatcct tcggaatgtg    480

ttcagaaccc aaacatcatg tcaatggcaa cagaacagtc gaacctttcc cagagggaac    540

acagatggct gtatttggaa tgggatgttt ctggggagct gaaaggaaat tctgggtctt    600

gaaaggagtg tattcaactc aagttggttt tgcaggaggc tatacttcaa atcctactta    660

taaagaagtc tgctcagaaa aaactggcca tgcagaagtc gtccgagtgg tgtaccagcc    720

agaacacatg agttttgagg aactgctcaa ggtcttctgg gagaatcacg acccgaccca    780

aggtatgcgc caggggaacg accatggcac tcagtaccgc tcggccatct acccgacctc    840

tgccaagcaa atggaggcag ccctgagctc caaagagaac taccaaaagg ttctttcaga    900

gcacggcttc ggccccatca ctaccgacat ccgggaggga cagactttct actatgcgga    960

agactaccac cagcagtacc tgagcaagaa ccccaatggc tactgcggcc ttgggggcac   1020

cggcgtgtcc tgcccagtgg gtattaaaaa ataatttctc cccacatggt gggcctttga   1080

ggttccagta aaaatgcttt caacaaattg ggcaatgctt gtgtgattca caatcgtggc   1140

atttaaagtg cacaaagtac aaaggaattt atacagattg ggtttaccga agtataatct   1200

ataggaggcg cgatggcaag ttgataaaat gtgacttatc tcctaataag ttatggtggg   1260

agtggagctg tgcagtttcc tgtgtcttct ggggtctgag tgaagatagc agggatgctg   1320

tgttcaccct tcttggtaga agctaaggtg tgagctggga ggttgctgga caggatgggg   1380

gaccccagaa gtcctttatc tgtgctctct gcccgccagt gccttacaat ttgcaaacgt   1440

gtatagcctc agtgactcat tcgctgaaat ccttcgcttt accaaatcta gacatacata   1500

aggggctttc tctccctttt cagccctctc tgtgcagaga aaagatgtga gtccgcttga   1560

tgaattctaa tgctttgctt agagctatga gaaatgtttg ttttaataaa aacctacagt   1620

ccaataatgc caa                                                      1633


<210>  2447
<211>  192
<212>  PRT
<213>  Homo sapiens

<400>  2447


Met Cys Ser Glu Pro Lys His His Val Asn Gly Asn Arg Thr Val Glu 
1               5                   10                  15      


Pro Phe Pro Glu Gly Thr Gln Met Ala Val Phe Gly Met Gly Cys Phe 
            20                  25                  30          


Trp Gly Ala Glu Arg Lys Phe Trp Val Leu Lys Gly Val Tyr Ser Thr 
        35                  40                  45              


Gln Val Gly Phe Ala Gly Gly Tyr Thr Ser Asn Pro Thr Tyr Lys Glu 
    50                  55                  60                  


Val Cys Ser Glu Lys Thr Gly His Ala Glu Val Val Arg Val Val Tyr 
65                  70                  75                  80  


Gln Pro Glu His Met Ser Phe Glu Glu Leu Leu Lys Val Phe Trp Glu 
                85                  90                  95      


Asn His Asp Pro Thr Gln Gly Met Arg Gln Gly Asn Asp His Gly Thr 
            100                 105                 110         


Gln Tyr Arg Ser Ala Ile Tyr Pro Thr Ser Ala Lys Gln Met Glu Ala 
        115                 120                 125             


Ala Leu Ser Ser Lys Glu Asn Tyr Gln Lys Val Leu Ser Glu His Gly 
    130                 135                 140                 


Phe Gly Pro Ile Thr Thr Asp Ile Arg Glu Gly Gln Thr Phe Tyr Tyr 
145                 150                 155                 160 


Ala Glu Asp Tyr His Gln Gln Tyr Leu Ser Lys Asn Pro Asn Gly Tyr 
                165                 170                 175     


Cys Gly Leu Gly Gly Thr Gly Val Ser Cys Pro Val Gly Ile Lys Lys 
            180                 185                 190         

<210>  2448
<211>  1708
<212>  DNA
<213>  Homo sapiens

<400>  2448
gagagagaga aagagggaga gagagaggca gagggagagc tgaggaaaga aaaaaaggca     60

agacttggca cagctcagtc aaatcagctt cttttgtctg ctttctcggc ttgagcttca    120

ggaaagaaaa ccgtcctggg gtacagaaaa actcagaact ttttggtttt caaacttaga    180

aggcttttta agtctcttgg gctatttgaa agtgttggta catacaatga cgtttagtca    240

ccagtattaa gggaaataaa agcctttttc aaaacgaagc ttccatagtg tccatgcatt    300

tgggaaatac tatatttgat tttttgcatg tatgattata ccatgagaga caggattaat    360

atagaagatg gcaaggcaaa tttctaatta gagggaatat taattttcta caaaataaag    420

tttgttcatc aatacaaacc tgctttcaaa tcaaatcaga aagacatcct tcggaatgtg    480

ttcagaacca attagtgaca acactgaaga ccagaaaggc aagctgaaga caccagactt    540

cgcttgaagg gcaaacaaga aatccaaaca tcatgtcaat ggcaacagaa cagtcgaacc    600

tttcccagag ggaacacaga tggctgtatt tggaatggga tgtttctggg gagctgaaag    660

gaaattctgg gtcttgaaag gagtgtattc aactcaagtt ggttttgcag gaggctatac    720

ttcaaatcct acttataaag aagtctgctc agaaaaaact ggccatgcag aagtcgtccg    780

agtggtgtac cagccagaac acatgagttt tgaggaactg ctcaaggtct tctgggagaa    840

tcacgacccg acccaaggta tgcgccaggg gaacgaccat ggcactcagt accgctcggc    900

catctacccg acctctgcca agcaaatgga ggcagccctg agctccaaag agaactacca    960

aaaggttctt tcagagcacg gcttcggccc catcactacc gacatccggg agggacagac   1020

tttctactat gcggaagact accaccagca gtacctgagc aagaacccca atggctactg   1080

cggccttggg ggcaccggcg tgtcctgccc agtgggtatt aaaaaataat ttctccccac   1140

atggtgggcc tttgaggttc cagtaaaaat gctttcaaca aattgggcaa tgcttgtgtg   1200

attcacaatc gtggcattta aagtgcacaa agtacaaagg aatttataca gattgggttt   1260

accgaagtat aatctatagg aggcgcgatg gcaagttgat aaaatgtgac ttatctccta   1320

ataagttatg gtgggagtgg agctgtgcag tttcctgtgt cttctggggt ctgagtgaag   1380

atagcaggga tgctgtgttc acccttcttg gtagaagcta aggtgtgagc tgggaggttg   1440

ctggacagga tgggggaccc cagaagtcct ttatctgtgc tctctgcccg ccagtgcctt   1500

acaatttgca aacgtgtata gcctcagtga ctcattcgct gaaatccttc gctttaccaa   1560

atctagacat acataagggg ctttctctcc cttttcagcc ctctctgtgc agagaaaaga   1620

tgtgagtccg cttgatgaat tctaatgctt tgcttagagc tatgagaaat gtttgtttta   1680

ataaaaacct acagtccaat aatgccaa                                      1708


<210>  2449
<211>  169
<212>  PRT
<213>  Homo sapiens

<400>  2449


Met Ala Val Phe Gly Met Gly Cys Phe Trp Gly Ala Glu Arg Lys Phe 
1               5                   10                  15      


Trp Val Leu Lys Gly Val Tyr Ser Thr Gln Val Gly Phe Ala Gly Gly 
            20                  25                  30          


Tyr Thr Ser Asn Pro Thr Tyr Lys Glu Val Cys Ser Glu Lys Thr Gly 
        35                  40                  45              


His Ala Glu Val Val Arg Val Val Tyr Gln Pro Glu His Met Ser Phe 
    50                  55                  60                  


Glu Glu Leu Leu Lys Val Phe Trp Glu Asn His Asp Pro Thr Gln Gly 
65                  70                  75                  80  


Met Arg Gln Gly Asn Asp His Gly Thr Gln Tyr Arg Ser Ala Ile Tyr 
                85                  90                  95      


Pro Thr Ser Ala Lys Gln Met Glu Ala Ala Leu Ser Ser Lys Glu Asn 
            100                 105                 110         


Tyr Gln Lys Val Leu Ser Glu His Gly Phe Gly Pro Ile Thr Thr Asp 
        115                 120                 125             


Ile Arg Glu Gly Gln Thr Phe Tyr Tyr Ala Glu Asp Tyr His Gln Gln 
    130                 135                 140                 


Tyr Leu Ser Lys Asn Pro Asn Gly Tyr Cys Gly Leu Gly Gly Thr Gly 
145                 150                 155                 160 


Val Ser Cys Pro Val Gly Ile Lys Lys 
                165                 

<210>  2450
<211>  2407
<212>  DNA
<213>  Homo sapiens

<400>  2450
ctccctccct cttccccctt cccctctccc tgcagccgcg tccacactgc gccgcccggg     60

cagcccagag cgcggcgcgc acgggcaccg gcggcgagtg ccgcggccac tgcccctccc    120

gggaccccct gtacgccgtc cgcgccgtcc agggtcacac cggcgacgga acccgccggc    180

agcaattagc cagcatcccg gggtcggccc ccagaagcat tccccggccc aggacgagga    240

tgaacaggac aggcgaggca caaagtcgca actgaacttt ttagaaacat tatttgtgtg    300

tgtatgtgtg tagcagggga gaatgagctg atgccgaggg tccagccacc ccgcctctgc    360

ctcctcctcc ccctgccgcc gctgccctcg cagacgcgcg cgcacacacg gcacttgggc    420

cgggtttccg cgctccgtcc ccccgtttgg atgggggttt tcatttccga aggaggcaca    480

gcccgcggag cgctctgaag ggctggagcc ccaagttact cctcgccagc gccggccgcc    540

cgctgtcact cgcgctggcc ggccggggga agggacccgc acgccgggct ttgttgtgga    600

aatcccggtt acctggtccc ttatttcgcg tgagtctttg gcgtccacga ccttgagtct    660

gacggaaagt cagtcggcct caagccatgc tggccacagg acccagtgca gccctgcttc    720

ccgcaccgtg ggtctttcct gatagctgca ggcttgagat tgcagcctca ggataggaca    780

cgttcagatg ccttccagac tacacacact atgcttagat tcgagagtct ttcctgacct    840

taaaatttgt cccttgctta ctttcacact gcagaagatt tatatatata ttcatcatta    900

tttttgcagc agtacaagtg gaaacttcaa aaaaatcatt ccctttcatg tcctggtctt    960

tttaagtctt gatatgtaac cattttcata aatgtccaaa cagagattgt cattcccctt   1020

aaaaacagaa acaaaacaca aaactagtgc ttgtgaaaac acacagcgca aagacaatta   1080

tcctattgca ttaaaaaaaa aatcagtctg cctagagaca tttcattggc tgcattgtct   1140

taattcccta acgaaactgc atcaaaatgt cagttgtaat ttagcctctg atcagctgtt   1200

aaatattatt taaatattta caggtcctgt ggggtatctc ccattaccca tgtcgccctc   1260

aaattacata agcgatcata aaataagaag aaaaaaaaag gtctttagta gatcacagca   1320

gagttaccac tgataagagt gttggctttg ttcagttgtt tctaaattac cagccgtcaa   1380

gcacagtagc ccctaaaacc aattttgagc aaggataaat tcaactccct catctgagaa   1440

ccttgacttt ccagttgcct tgaagtattg ggaatagtaa ctgtacattt tcaatttaat   1500

tatttggtat tttatttgac tgtcttggcc atgtcatttt atggaagcat ttttaaatag   1560

cactttttgt tagtggtgtg gaatttctgc ggttattatt tttttttttt tttgcaacag   1620

atgaagcaaa aaaaaaaaag cactcattgg agaaatagtg agtgtaaaaa gagatttatt   1680

ttgtacagac agcaaagtat cctgtgtaat gttgctgaca taaagcactt tgggggaaaa   1740

aagtggaaat ctgttttcca taaatcacac agactcttgt acatagttat atacactcac   1800

gtagagaaat gaactgcata tatcatactg gatatggggc cgattttact ctagaggcac   1860

atctggtgct tattgtcata aatcttttaa agaattaggt acactttttt ctattaatat   1920

gtatagtttt gtgatttgtc acagttatgt ttcatataat cataagttat tttgtcttgt   1980

tcatgaagtc ctttttttat gtcaaaagta aaatgaaggg attgtgcact tggtacagaa   2040

taaaactgga aatagagaag acgccctcct gcctaaaatc ctccttcagc ctgtcggttt   2100

aaaacacaat ggcaaccatc attgtttgtt tgtttgtttt tttgttttgt tttaccatca   2160

gcctcttaca tactgggaat ggtaattata attaaaggca gatgatgcgg gagggaatgt   2220

tcaagtccag ctttaaaatg ctgcattgct ttgggccaga gctgtagcct ggatttaatt   2280

atagatatga ggaggaaatg gcagtaaaaa tgaatgtctc cctgagtcct ttacatgttg   2340

ggagtgtcca taaataaaac atgaagtttt atttcatcag atttaattaa agcttttata   2400

catgttt                                                             2407


<210>  2451
<211>  73
<212>  PRT
<213>  Homo sapiens

<400>  2451


Met Ser Lys Gln Arg Leu Ser Phe Pro Leu Lys Thr Glu Thr Lys His 
1               5                   10                  15      


Lys Thr Ser Ala Cys Glu Asn Thr Gln Arg Lys Asp Asn Tyr Pro Ile 
            20                  25                  30          


Ala Leu Lys Lys Lys Ser Val Cys Leu Glu Thr Phe His Trp Leu His 
        35                  40                  45              


Cys Leu Asn Ser Leu Thr Lys Leu His Gln Asn Val Ser Cys Asn Leu 
    50                  55                  60                  


Ala Ser Asp Gln Leu Leu Asn Ile Ile 
65                  70              

<210>  2452
<211>  847
<212>  DNA
<213>  Homo sapiens

<400>  2452
ctccctccct cttccccctt cccctctccc tgcagccgcg tccacactgc gccgcccggg     60

cagcccagag cgcggcgcgc acgggcaccg gcggcgagtg ccgcggccac tgcccctccc    120

gggaccccct gtacgccgtc cgcgccgtcc agggtcacac cggcgacgga acccgccggc    180

agcaattagc cagcatcccg gggtcggccc ccagaagcat tccccggccc aggacgagga    240

tgaacaggac aggcgaggca caaagtcgca actgaacttt ttagaaacat tatttgtgtg    300

tgtatgtgtg tagcagggga gaatgagctg atgccgaggg tccagccacc ccgcctctgc    360

ctcctcctcc ccctgccgcc gctgccctcg cagacgcgcg cgcacacacg gcacttgggc    420

cgggtttccg cgctccgtcc ccccgtttgg atgggggttt tcatttccga aggaggcaca    480

gcccgcggag cgctctgaag ggctggagcc ccaagttact cctcgccagc gccggccgcc    540

cgctgtcact cgcgctggcc ggccggggga agggacccgc acgccgggct ttgttgtgga    600

aatcccggtt acctggtccc ttatttcgcg tgagtctttg gcgtccacga ccttgagtct    660

gacggaaagt cagtcggcct caagcatgaa gcaggagtgg tcccagggct acagggccct    720

cccttcgctc tccaaccacg gctctcagaa tggccttgat ctaggggatc tccttagcct    780

tcctcccggg acatccatgt ccagcaatag tgtctctaac tcattaccat cctacctttt    840

tggcacg                                                              847


<210>  2453
<211>  64
<212>  PRT
<213>  Homo sapiens

<400>  2453


Met Cys Val Ala Gly Glu Asn Glu Leu Met Pro Arg Val Gln Pro Pro 
1               5                   10                  15      


Arg Leu Cys Leu Leu Leu Pro Leu Pro Pro Leu Pro Ser Gln Thr Arg 
            20                  25                  30          


Ala His Thr Arg His Leu Gly Arg Val Ser Ala Leu Arg Pro Pro Val 
        35                  40                  45              


Trp Met Gly Val Phe Ile Ser Glu Gly Gly Thr Ala Arg Gly Ala Leu 
    50                  55                  60                  

<210>  2454
<211>  1166
<212>  DNA
<213>  Homo sapiens

<400>  2454
ctccctccct cttccccctt cccctctccc tgcagccgcg tccacactgc gccgcccggg     60

cagcccagag cgcggcgcgc acgggcaccg gcggcgagtg ccgcggccac tgcccctccc    120

gggaccccct gtacgccgtc cgcgccgtcc agggtcacac cggcgacgga acccgccggc    180

agcaattagc cagcatcccg gggtcggccc ccagaagcat tccccggccc aggacgagga    240

tgaacaggac aggcgaggca caaagtcgca actgaacttt ttagaaacat tatttgtgtg    300

tgtatgtgtg tagcagggga gaatgagctg atgccgaggg tccagccacc ccgcctctgc    360

ctcctcctcc ccctgccgcc gctgccctcg cagacgcgcg cgcacacacg gcacttgggc    420

cgggtttccg cgctccgtcc ccccgtttgg atgggggttt tcatttccga aggaggcaca    480

gcccgcggag cgctctgaag ggctggagcc ccaagttact cctcgccagc gccggccgcc    540

cgctgtcact cgcgctggcc ggccggggga agggacccgc acgccgggct ttgttgtgga    600

aatcccggtt acctggctta taacccacac catggataac ttattggact ttgcctgaaa    660

ggagtcatta gtgacattgg atatttgacc gtcttggcca caggtttttc agaatgaatg    720

gaagatcatg cagcatgagt ctccaccgga catcgggaac cccacagggg cctaggatgg    780

tcagtggtca tcacattcct gccatccgag cccactccgg gactcctggc ccctcgccct    840

gtggcagcac atcgagtccc actatggcaa gccttgctaa caacctccat ctcaagatgc    900

cctcaggagg agggatggct cctcagaaca acgtggctga gagccgcatc catctgcctg    960

ccttaagccc caggagacaa atgctcacca atgggaagcc gcgattccag gtcacccagg   1020

ctggaggcat gtcagggtca catactttaa agccaaagca gcaggagttt ggaagccctt   1080

ttcctccaaa tcctgggaaa gtgaagtccc atgggatact ggagcagtta atgtgtggtc   1140

ccatcccctg ccaggatgac cgctga                                        1166


<210>  2455
<211>  150
<212>  PRT
<213>  Homo sapiens

<400>  2455


Met Asn Gly Arg Ser Cys Ser Met Ser Leu His Arg Thr Ser Gly Thr 
1               5                   10                  15      


Pro Gln Gly Pro Arg Met Val Ser Gly His His Ile Pro Ala Ile Arg 
            20                  25                  30          


Ala His Ser Gly Thr Pro Gly Pro Ser Pro Cys Gly Ser Thr Ser Ser 
        35                  40                  45              


Pro Thr Met Ala Ser Leu Ala Asn Asn Leu His Leu Lys Met Pro Ser 
    50                  55                  60                  


Gly Gly Gly Met Ala Pro Gln Asn Asn Val Ala Glu Ser Arg Ile His 
65                  70                  75                  80  


Leu Pro Ala Leu Ser Pro Arg Arg Gln Met Leu Thr Asn Gly Lys Pro 
                85                  90                  95      


Arg Phe Gln Val Thr Gln Ala Gly Gly Met Ser Gly Ser His Thr Leu 
            100                 105                 110         


Lys Pro Lys Gln Gln Glu Phe Gly Ser Pro Phe Pro Pro Asn Pro Gly 
        115                 120                 125             


Lys Val Lys Ser His Gly Ile Leu Glu Gln Leu Met Cys Gly Pro Ile 
    130                 135                 140                 


Pro Cys Gln Asp Asp Arg 
145                 150 

<210>  2456
<211>  6728
<212>  DNA
<213>  Homo sapiens

<400>  2456
tagtgaggct aatcccgaag cagcacattc caaggggcta atctgcccaa gttcattgct     60

tacttgaaac gtctcttggg ggaagagccg aacaagtgac tttttttttc cagtgggcgg    120

tcataagagc attattaacg gaatgaccag ccctagctgc agcaaaatga aagcaacagg    180

agctgctccg gggactgctt ttgccagtac ccagaatcag tgctcaggct cagaaatcct    240

ggatagaaag agcattttat aaaagagaat gtgtccacat catacccagc accaaagacc    300

cccataggtg ttgctgtggg cgtctgatag gccagcatgt tggcctcacc cccagtatct    360

ccgtgcttca gaatgagaaa aatgaaagtc gcctctcccg aaatgacatc cagtctgaaa    420

agtggtccat cagcaaacac actcaactca gccctacgga tgcttttggg accattgagt    480

tccaaggagg tggccattcc aacaaagcca tgtatgtgcg agtatctttt gatacaaaac    540

ctgatctcct cttacacctg atgaccaagg aatggcagtt ggagcttccc aagcttctca    600

tctctgtcca tgggggcctg cagaactttg aactccagcc aaaactcaag caagtctttg    660

ggaaagggct catcaaagca gcaatgacaa ctggagcgtg gatattcact ggaggggtta    720

acacaggtgt tattcgtcat gttggcgatg ccttgaagga tcatgcctct aagtctcgag    780

gaaagatatg caccataggt attgccccct ggggaattgt ggaaaaccag gaggacctca    840

ttggaagaga tgttgtccgg ccataccaga ccatgtccaa tcccatgagc aagctcactg    900

ttctcaacag catgcattcc cacttcattc tggctgacaa cgggaccact ggaaaatatg    960

gagcagaggt gaaacttcga agacaactgg aaaagcatat ttcactccag aagataaaca   1020

caagatgcct gccgtttttc tctcttgact cccgcttgtt ttattcattt tggggtagtt   1080

gccagttaga ctcagttgga atcggtcaag gtgttcctgt ggtggcactc atagtggaag   1140

gaggacccaa tgtgatctcg attgttttgg agtaccttcg agacacccct cccgtgccag   1200

tggttgtctg tgatgggagt ggacgggcat cggacatcct ggcctttggg cataaatact   1260

cagaagaagg cggactgata aatgaatctt tgagggacca gctgttggtg actatacaga   1320

agactttcac atacactcga acccaagctc agcatctgtt catcatcctc atggagtgca   1380

tgaagaagaa ggaattgatt acggtatttc ggatgggatc agaaggacac caggacattg   1440

atttggctat cctgacagct ttactcaaag gagccaatgc ctcggcccca gaccaactga   1500

gcttagcttt agcctggaac agagtcgaca tcgctcgcag ccagatcttt atttacgggc   1560

aacagtggcc ggtgggatct ctggagcaag ccatgttgga tgccttagtt ctggacagag   1620

tggattttgt gaaattactc atagagaatg gagtaagcat gcaccgtttt ctcaccatct   1680

ccagactaga ggaattgtac aatacgagac atgggccctc aaatacattg taccacttgg   1740

tcagggatgt caaaaagggg aacctgcccc cagactacag aatcagcctg attgacatcg   1800

gcctggtgat cgagtacctg atgggcgggg cttatcgctg caactacacg cgcaagcgct   1860

tccggaccct ctaccacaac ctcttcggcc ccaagaggcc caaagccttg aaactgctgg   1920

gaatggagga tgatattccc ttgaggcgag gaagaaagac aaccaagaaa cgtgaagaag   1980

aggtggacat tgacttggat gatcctgaga tcaaccactt ccccttccct ttccatgagc   2040

tcatggtgtg ggctgttctc atgaagcggc agaagatggc cctgttcttc tggcagcacg   2100

gtgaggaggc catggccaag gccctggtgg cctgcaagct ctgcaaagcc atggctcatg   2160

aggcctctga gaacgacatg gttgacgaca tttcccagga gctgaatcac aattccagag   2220

actttggcca gctggctgtg gagctcctgg accagtccta caagcaggac gaacagctgg   2280

ccatgaaact gctgacgtat gagctgaaga actggagcaa cgccacgtgc ctgcagcttg   2340

ccgtggctgc caaacaccgc gacttcatcg cgcacacgtg cagccagatg ctgctcaccg   2400

acatgtggat gggccggctc cgcatgcgca agaactcagg cctcaaggta attctgggaa   2460

ttctacttcc tccttcaatt ctcagcttgg agttcaagaa caaagacgac atgccctata   2520

tgtctcaggc ccaggaaatc cacctccaag agaaggaggc agaagaacca gagaagccca   2580

caaaggaaaa agaggaagag gacatggagc tcacagcaat gttgggacga aacaacgggg   2640

agtcctccag gaagaaggat gaagaggaag ttcagagcaa gcaccggtta atccccctcg   2700

gcagaaaaat ctatgaattc tacaatgcac ccatcgtgaa gttctggttc tacacactgg   2760

cgtatatcgg atacctgatg ctcttcaact atatcgtgtt agtgaagatg gaacgctggc   2820

cgtccaccca ggaatggatc gtaatctcct atattttcac cctgggaata gaaaagatga   2880

gagagattct gatgtcagag ccagggaagt tgctacagaa agtgaaggta tggctgcagg   2940

agtactggaa tgtcacggac ctcatcgcca tccttctgtt ttctgtcgga atgatccttc   3000

gtctccaaga ccagcccttc aggagtgacg ggagggtcat ctactgcgtg aacatcattt   3060

actggtatat ccgtctccta gacatcttcg gcgtgaacaa gtatttgggc ccgtatgtaa   3120

tgatgattgg aaaaatgatg atagacatga tgtactttgt catcattatg ctggtggttc   3180

tgatgagctt tggggtcgcc aggcaagcca tcctttttcc caatgaggag ccatcatgga   3240

aactggccaa gaacatcttc tacatgccct attggatgat ttatggggaa gtgtttgcgg   3300

accagataga ccctccctgt ggacagaatg agacccgaga ggatggtaaa ataatccagc   3360

tgcctccctg caagacagga gcttggatcg tgccggccat catggcctgc tacctcttag   3420

tggcaaacat cttgctggtc aacctcctca ttgctgtctt taacaataca ttttttgaag   3480

taaaatcgat atccaaccaa gtctggaagt ttcagaggta tcagctcatc atgactttcc   3540

atgaaaggcc agttctgccc ccaccactga tcatcttcag ccacatgacc atgatattcc   3600

agcacctgtg ctgccgatgg aggaaacacg agagcgaccc ggatgaaagg gactacggcc   3660

tgaaactctt cataaccgat gatgagctca agaaagtaca tgactttgaa gagcaatgca   3720

tagaagaata cttcagagaa aaggatgatc ggttcaactc atctaatgat gagaggatac   3780

gggtgacttc agaaagggtg gagaacatgt ctatgcggct ggaggaagtc aacgagagag   3840

agcactccat gaaggcttca ctccagaccg tggacatccg gctggcgcag ctggaagacc   3900

ttatcgggcg catggccacg gccctggagc gcctgacagg tctggagcgg gccgagtcca   3960

acaaaatccg ctcgaggacc tcgtcagact gcacggacgc cgcctacatt gtccgtcaga   4020

gcagcttcaa cagccaggaa gggaacacct tcaagctcca agagagtata gaccctgcag   4080

gtgaggagac catgtcccca acttctccaa ccttaatgcc ccgtatgcga agccattctt   4140

tctattcggt caatatgaaa gacaaaggtg gtatagaaaa gttggaaagt atttttaaag   4200

aaaggtccct gagcctacac cgggctacta gttcccactc tgtagcaaaa gaacccaaag   4260

ctcctgcagc ccctgccaac accttggcca ttgttcctga ttccagaaga ccatcatcgt   4320

gtatagacat ctatgtctct gctatggatg agctccactg tgatatagac cctctggaca   4380

attccgtgaa catccttggg ctgggcgagc caagcttttc aactccagta ccttccacag   4440

ccccttcaag tagtgcctat gcaacacttg cacccacaga cagacctcca agccggagca   4500

ttgattttga ggacatcacc tccatggaca ctagatcttt ttcttcagac tacacccacc   4560

tcccagaatg ccaaaacccc tgggactcag agcctccgat gtaccacacc attgagcgtt   4620

ccaaaagtag ccgctaccta gccaccacac cctttcttct agaagaggct cccattgtga   4680

aatctcatag ctttatgttt tccccctcaa ggagctatta tgccaacttt ggggtgcctg   4740

taaaaacagc agaatacaca agtattacag actgtattga cacaaggtgt gtcaatgccc   4800

ctcaagcaat tgcggacaga gctgccttcc ctggaggtct tggagacaaa gtggaggact   4860

taacttgctg ccatccagag cgagaagcag aactgagtca ccccagctct gacagtgagg   4920

agaatgaggc caaaggccgc agagccacca ttgcaatatc ctcccaggag ggtgataact   4980

cagagagaac cctgtccaac aacatcactg ttcccaagat agagcgcgcc aacagctact   5040

cggcagagga gccaagtgcg ccatatgcac acaccaggaa gagcttctcc atcagtgaca   5100

aactcgacag gcagcggaac acagcaagcc tgcgaaatcc cttccagaga agcaagtcct   5160

ccaagccgga gggccgaggg gacagcctgt ccatgaggag actgtccaga acatcggctt   5220

tccaaagctt tgaaagcaag cacaactaaa ccttcttaat atccgccaca gaaggctcaa   5280

gaatccagcc ctaaaattct ctccaactcc agtttttccc ctttccttga atcatacctg   5340

ctttattctt agctgagcaa aacaagcaat gctttgggag gtgttaactc aaaggtgact   5400

tctgggccac agatcaagaa agcatttgat ctgacccagt gccagacaca ggggatttaa   5460

ggcatgttca cacttgctgg gcagggaggg ggaagagagg gagaaggaag ggttagagat   5520

gaatgtgtat ccgcagtcac agcagaaagc catgagagca ggggaaacaa ggggcttcga   5580

gcacgctcca tgccaggagg catctgttga tttctgacca ttatcaagag ttgtaggatg   5640

cagggctaaa ttgcaaaata aaataaaata gccagcgtac acaatgagat attctaaact   5700

tccattctgt tttcttttca cattggctcc atcactggtg actgatgaag agcatcctct   5760

ttattcagta taagccggca gcaagcagtt ctacctaacg tcccacatcc ttctcatgcc   5820

aacacttctg taattgatca ttataaagaa aaaacaaggt aacagtcata gttcacctgt   5880

ctcttatcta ttcacttctg gtgccacaac tgtttatcct tttttgaaga aaataaggga   5940

acagaaatgc ctttttgtat tgcaatcgaa atgaaagaag agttgatgtt aaaaaaacaa   6000

aagtcaagtg atttattata tacagtgggc gttcaagtct agtcgagcaa gctcaggaga   6060

atgtaattaa ataattttat attttttaat ttattttgta tctcacctgt catggatgaa   6120

ttcattcact gaatatgtaa tattgaactt aaaaaaaaaa aaaaaaaaac agtggacaga   6180

actagcctga aattgccatg tgggatgttc tgttctcacc gttcatgtcg tgtgttgtgc   6240

tgctgtgtga ccgtcatcat ttgcatggct ccaccacgtc ctcctgaaca cctccaagac   6300

gtaactgcca atttttcaca ccactcatca catgaccatt ttgtatatga atatatggtt   6360

atatgtggat attttcatac ctagagtttt gccatctaat ctgagctcag cataaattta   6420

attggagttt ttcaagggct ggtatctttt ctatggaaat gttccaaagt actttttaag   6480

gaagtttcaa aactataaat aaccttagat ttgactggga gtttggtatc aacccaaagc   6540

catcagttgc aagcatacca tgaatatttt tcttatagac agagctataa aaaaagatac   6600

agtagaccaa aatagaaagc aaataaacca tataaagagt tctatagtat atgccactta   6660

tacacatgta tatgcattta tgcagagaca catatttata tataaaataa atggacataa   6720

agagcttt                                                            6728


<210>  2457
<211>  1579
<212>  PRT
<213>  Homo sapiens

<400>  2457


Met Tyr Val Arg Val Ser Phe Asp Thr Lys Pro Asp Leu Leu Leu His 
1               5                   10                  15      


Leu Met Thr Lys Glu Trp Gln Leu Glu Leu Pro Lys Leu Leu Ile Ser 
            20                  25                  30          


Val His Gly Gly Leu Gln Asn Phe Glu Leu Gln Pro Lys Leu Lys Gln 
        35                  40                  45              


Val Phe Gly Lys Gly Leu Ile Lys Ala Ala Met Thr Thr Gly Ala Trp 
    50                  55                  60                  


Ile Phe Thr Gly Gly Val Asn Thr Gly Val Ile Arg His Val Gly Asp 
65                  70                  75                  80  


Ala Leu Lys Asp His Ala Ser Lys Ser Arg Gly Lys Ile Cys Thr Ile 
                85                  90                  95      


Gly Ile Ala Pro Trp Gly Ile Val Glu Asn Gln Glu Asp Leu Ile Gly 
            100                 105                 110         


Arg Asp Val Val Arg Pro Tyr Gln Thr Met Ser Asn Pro Met Ser Lys 
        115                 120                 125             


Leu Thr Val Leu Asn Ser Met His Ser His Phe Ile Leu Ala Asp Asn 
    130                 135                 140                 


Gly Thr Thr Gly Lys Tyr Gly Ala Glu Val Lys Leu Arg Arg Gln Leu 
145                 150                 155                 160 


Glu Lys His Ile Ser Leu Gln Lys Ile Asn Thr Arg Cys Leu Pro Phe 
                165                 170                 175     


Phe Ser Leu Asp Ser Arg Leu Phe Tyr Ser Phe Trp Gly Ser Cys Gln 
            180                 185                 190         


Leu Asp Ser Val Gly Ile Gly Gln Gly Val Pro Val Val Ala Leu Ile 
        195                 200                 205             


Val Glu Gly Gly Pro Asn Val Ile Ser Ile Val Leu Glu Tyr Leu Arg 
    210                 215                 220                 


Asp Thr Pro Pro Val Pro Val Val Val Cys Asp Gly Ser Gly Arg Ala 
225                 230                 235                 240 


Ser Asp Ile Leu Ala Phe Gly His Lys Tyr Ser Glu Glu Gly Gly Leu 
                245                 250                 255     


Ile Asn Glu Ser Leu Arg Asp Gln Leu Leu Val Thr Ile Gln Lys Thr 
            260                 265                 270         


Phe Thr Tyr Thr Arg Thr Gln Ala Gln His Leu Phe Ile Ile Leu Met 
        275                 280                 285             


Glu Cys Met Lys Lys Lys Glu Leu Ile Thr Val Phe Arg Met Gly Ser 
    290                 295                 300                 


Glu Gly His Gln Asp Ile Asp Leu Ala Ile Leu Thr Ala Leu Leu Lys 
305                 310                 315                 320 


Gly Ala Asn Ala Ser Ala Pro Asp Gln Leu Ser Leu Ala Leu Ala Trp 
                325                 330                 335     


Asn Arg Val Asp Ile Ala Arg Ser Gln Ile Phe Ile Tyr Gly Gln Gln 
            340                 345                 350         


Trp Pro Val Gly Ser Leu Glu Gln Ala Met Leu Asp Ala Leu Val Leu 
        355                 360                 365             


Asp Arg Val Asp Phe Val Lys Leu Leu Ile Glu Asn Gly Val Ser Met 
    370                 375                 380                 


His Arg Phe Leu Thr Ile Ser Arg Leu Glu Glu Leu Tyr Asn Thr Arg 
385                 390                 395                 400 


His Gly Pro Ser Asn Thr Leu Tyr His Leu Val Arg Asp Val Lys Lys 
                405                 410                 415     


Gly Asn Leu Pro Pro Asp Tyr Arg Ile Ser Leu Ile Asp Ile Gly Leu 
            420                 425                 430         


Val Ile Glu Tyr Leu Met Gly Gly Ala Tyr Arg Cys Asn Tyr Thr Arg 
        435                 440                 445             


Lys Arg Phe Arg Thr Leu Tyr His Asn Leu Phe Gly Pro Lys Arg Pro 
    450                 455                 460                 


Lys Ala Leu Lys Leu Leu Gly Met Glu Asp Asp Ile Pro Leu Arg Arg 
465                 470                 475                 480 


Gly Arg Lys Thr Thr Lys Lys Arg Glu Glu Glu Val Asp Ile Asp Leu 
                485                 490                 495     


Asp Asp Pro Glu Ile Asn His Phe Pro Phe Pro Phe His Glu Leu Met 
            500                 505                 510         


Val Trp Ala Val Leu Met Lys Arg Gln Lys Met Ala Leu Phe Phe Trp 
        515                 520                 525             


Gln His Gly Glu Glu Ala Met Ala Lys Ala Leu Val Ala Cys Lys Leu 
    530                 535                 540                 


Cys Lys Ala Met Ala His Glu Ala Ser Glu Asn Asp Met Val Asp Asp 
545                 550                 555                 560 


Ile Ser Gln Glu Leu Asn His Asn Ser Arg Asp Phe Gly Gln Leu Ala 
                565                 570                 575     


Val Glu Leu Leu Asp Gln Ser Tyr Lys Gln Asp Glu Gln Leu Ala Met 
            580                 585                 590         


Lys Leu Leu Thr Tyr Glu Leu Lys Asn Trp Ser Asn Ala Thr Cys Leu 
        595                 600                 605             


Gln Leu Ala Val Ala Ala Lys His Arg Asp Phe Ile Ala His Thr Cys 
    610                 615                 620                 


Ser Gln Met Leu Leu Thr Asp Met Trp Met Gly Arg Leu Arg Met Arg 
625                 630                 635                 640 


Lys Asn Ser Gly Leu Lys Val Ile Leu Gly Ile Leu Leu Pro Pro Ser 
                645                 650                 655     


Ile Leu Ser Leu Glu Phe Lys Asn Lys Asp Asp Met Pro Tyr Met Ser 
            660                 665                 670         


Gln Ala Gln Glu Ile His Leu Gln Glu Lys Glu Ala Glu Glu Pro Glu 
        675                 680                 685             


Lys Pro Thr Lys Glu Lys Glu Glu Glu Asp Met Glu Leu Thr Ala Met 
    690                 695                 700                 


Leu Gly Arg Asn Asn Gly Glu Ser Ser Arg Lys Lys Asp Glu Glu Glu 
705                 710                 715                 720 


Val Gln Ser Lys His Arg Leu Ile Pro Leu Gly Arg Lys Ile Tyr Glu 
                725                 730                 735     


Phe Tyr Asn Ala Pro Ile Val Lys Phe Trp Phe Tyr Thr Leu Ala Tyr 
            740                 745                 750         


Ile Gly Tyr Leu Met Leu Phe Asn Tyr Ile Val Leu Val Lys Met Glu 
        755                 760                 765             


Arg Trp Pro Ser Thr Gln Glu Trp Ile Val Ile Ser Tyr Ile Phe Thr 
    770                 775                 780                 


Leu Gly Ile Glu Lys Met Arg Glu Ile Leu Met Ser Glu Pro Gly Lys 
785                 790                 795                 800 


Leu Leu Gln Lys Val Lys Val Trp Leu Gln Glu Tyr Trp Asn Val Thr 
                805                 810                 815     


Asp Leu Ile Ala Ile Leu Leu Phe Ser Val Gly Met Ile Leu Arg Leu 
            820                 825                 830         


Gln Asp Gln Pro Phe Arg Ser Asp Gly Arg Val Ile Tyr Cys Val Asn 
        835                 840                 845             


Ile Ile Tyr Trp Tyr Ile Arg Leu Leu Asp Ile Phe Gly Val Asn Lys 
    850                 855                 860                 


Tyr Leu Gly Pro Tyr Val Met Met Ile Gly Lys Met Met Ile Asp Met 
865                 870                 875                 880 


Met Tyr Phe Val Ile Ile Met Leu Val Val Leu Met Ser Phe Gly Val 
                885                 890                 895     


Ala Arg Gln Ala Ile Leu Phe Pro Asn Glu Glu Pro Ser Trp Lys Leu 
            900                 905                 910         


Ala Lys Asn Ile Phe Tyr Met Pro Tyr Trp Met Ile Tyr Gly Glu Val 
        915                 920                 925             


Phe Ala Asp Gln Ile Asp Pro Pro Cys Gly Gln Asn Glu Thr Arg Glu 
    930                 935                 940                 


Asp Gly Lys Ile Ile Gln Leu Pro Pro Cys Lys Thr Gly Ala Trp Ile 
945                 950                 955                 960 


Val Pro Ala Ile Met Ala Cys Tyr Leu Leu Val Ala Asn Ile Leu Leu 
                965                 970                 975     


Val Asn Leu Leu Ile Ala Val Phe Asn Asn Thr Phe Phe Glu Val Lys 
            980                 985                 990         


Ser Ile Ser Asn Gln Val Trp Lys  Phe Gln Arg Tyr Gln  Leu Ile Met 
        995                 1000                 1005             


Thr Phe  His Glu Arg Pro Val  Leu Pro Pro Pro Leu  Ile Ile Phe 
    1010                 1015                 1020             


Ser His  Met Thr Met Ile Phe  Gln His Leu Cys Cys  Arg Trp Arg 
    1025                 1030                 1035             


Lys His  Glu Ser Asp Pro Asp  Glu Arg Asp Tyr Gly  Leu Lys Leu 
    1040                 1045                 1050             


Phe Ile  Thr Asp Asp Glu Leu  Lys Lys Val His Asp  Phe Glu Glu 
    1055                 1060                 1065             


Gln Cys  Ile Glu Glu Tyr Phe  Arg Glu Lys Asp Asp  Arg Phe Asn 
    1070                 1075                 1080             


Ser Ser  Asn Asp Glu Arg Ile  Arg Val Thr Ser Glu  Arg Val Glu 
    1085                 1090                 1095             


Asn Met  Ser Met Arg Leu Glu  Glu Val Asn Glu Arg  Glu His Ser 
    1100                 1105                 1110             


Met Lys  Ala Ser Leu Gln Thr  Val Asp Ile Arg Leu  Ala Gln Leu 
    1115                 1120                 1125             


Glu Asp  Leu Ile Gly Arg Met  Ala Thr Ala Leu Glu  Arg Leu Thr 
    1130                 1135                 1140             


Gly Leu  Glu Arg Ala Glu Ser  Asn Lys Ile Arg Ser  Arg Thr Ser 
    1145                 1150                 1155             


Ser Asp  Cys Thr Asp Ala Ala  Tyr Ile Val Arg Gln  Ser Ser Phe 
    1160                 1165                 1170             


Asn Ser  Gln Glu Gly Asn Thr  Phe Lys Leu Gln Glu  Ser Ile Asp 
    1175                 1180                 1185             


Pro Ala  Gly Glu Glu Thr Met  Ser Pro Thr Ser Pro  Thr Leu Met 
    1190                 1195                 1200             


Pro Arg  Met Arg Ser His Ser  Phe Tyr Ser Val Asn  Met Lys Asp 
    1205                 1210                 1215             


Lys Gly  Gly Ile Glu Lys Leu  Glu Ser Ile Phe Lys  Glu Arg Ser 
    1220                 1225                 1230             


Leu Ser  Leu His Arg Ala Thr  Ser Ser His Ser Val  Ala Lys Glu 
    1235                 1240                 1245             


Pro Lys  Ala Pro Ala Ala Pro  Ala Asn Thr Leu Ala  Ile Val Pro 
    1250                 1255                 1260             


Asp Ser  Arg Arg Pro Ser Ser  Cys Ile Asp Ile Tyr  Val Ser Ala 
    1265                 1270                 1275             


Met Asp  Glu Leu His Cys Asp  Ile Asp Pro Leu Asp  Asn Ser Val 
    1280                 1285                 1290             


Asn Ile  Leu Gly Leu Gly Glu  Pro Ser Phe Ser Thr  Pro Val Pro 
    1295                 1300                 1305             


Ser Thr  Ala Pro Ser Ser Ser  Ala Tyr Ala Thr Leu  Ala Pro Thr 
    1310                 1315                 1320             


Asp Arg  Pro Pro Ser Arg Ser  Ile Asp Phe Glu Asp  Ile Thr Ser 
    1325                 1330                 1335             


Met Asp  Thr Arg Ser Phe Ser  Ser Asp Tyr Thr His  Leu Pro Glu 
    1340                 1345                 1350             


Cys Gln  Asn Pro Trp Asp Ser  Glu Pro Pro Met Tyr  His Thr Ile 
    1355                 1360                 1365             


Glu Arg  Ser Lys Ser Ser Arg  Tyr Leu Ala Thr Thr  Pro Phe Leu 
    1370                 1375                 1380             


Leu Glu  Glu Ala Pro Ile Val  Lys Ser His Ser Phe  Met Phe Ser 
    1385                 1390                 1395             


Pro Ser  Arg Ser Tyr Tyr Ala  Asn Phe Gly Val Pro  Val Lys Thr 
    1400                 1405                 1410             


Ala Glu  Tyr Thr Ser Ile Thr  Asp Cys Ile Asp Thr  Arg Cys Val 
    1415                 1420                 1425             


Asn Ala  Pro Gln Ala Ile Ala  Asp Arg Ala Ala Phe  Pro Gly Gly 
    1430                 1435                 1440             


Leu Gly  Asp Lys Val Glu Asp  Leu Thr Cys Cys His  Pro Glu Arg 
    1445                 1450                 1455             


Glu Ala  Glu Leu Ser His Pro  Ser Ser Asp Ser Glu  Glu Asn Glu 
    1460                 1465                 1470             


Ala Lys  Gly Arg Arg Ala Thr  Ile Ala Ile Ser Ser  Gln Glu Gly 
    1475                 1480                 1485             


Asp Asn  Ser Glu Arg Thr Leu  Ser Asn Asn Ile Thr  Val Pro Lys 
    1490                 1495                 1500             


Ile Glu  Arg Ala Asn Ser Tyr  Ser Ala Glu Glu Pro  Ser Ala Pro 
    1505                 1510                 1515             


Tyr Ala  His Thr Arg Lys Ser  Phe Ser Ile Ser Asp  Lys Leu Asp 
    1520                 1525                 1530             


Arg Gln  Arg Asn Thr Ala Ser  Leu Arg Asn Pro Phe  Gln Arg Ser 
    1535                 1540                 1545             


Lys Ser  Ser Lys Pro Glu Gly  Arg Gly Asp Ser Leu  Ser Met Arg 
    1550                 1555                 1560             


Arg Leu  Ser Arg Thr Ser Ala  Phe Gln Ser Phe Glu  Ser Lys His 
    1565                 1570                 1575             


Asn 
    

<210>  2458
<211>  6623
<212>  DNA
<213>  Homo sapiens

<400>  2458
tagtgaggct aatcccgaag cagcacattc caaggggcta atctgcccaa gttcattgct     60

tacttgaaac gtctcttggg ggaagagccg aacaagtgac tttttttttc cagtgggcgg    120

tcataagagc attattaacg gaatgaccag ccctagctgc agcaaaatga aagcaacagg    180

agctgctccg gggactgctt ttgccagtac ccagaatcag tgctcaggct cagaaatcct    240

ggatagaaag agcattttat aaaagagaat gtgtccacat catacccagc accaaagacc    300

cccataggtg ttgctgtggg cgtctgatag gccagcatgt tggcctcacc cccagtatct    360

ccgtgcttca gaatgagaaa aatgaaagtc gcctctcccg aaatgacatc cagtctgaaa    420

agtggtccat cagcaaacac actcaactca gccctacgga tgcttttggg accattgagt    480

tccaaggagg tggccattcc aacaaagcca tgtatgtgcg agtatctttt gatacaaaac    540

ctgatctcct cttacacctg atgaccaagg aatggcagtt ggagcttccc aagcttctca    600

tctctgtcca tgggggcctg cagaactttg aactccagcc aaaactcaag caagtctttg    660

ggaaagggct catcaaagca gcaatgacaa ctggagcgtg gatattcact ggaggggtta    720

acacaggtgt tattcgtcat gttggcgatg ccttgaagga tcatgcctct aagtctcgag    780

gaaagatatg caccataggt attgccccct ggggaattgt ggaaaaccag gaggacctca    840

ttggaagaga tgttgtccgg ccataccaga ccatgtccaa tcccatgagc aagctcactg    900

ttctcaacag catgcattcc cacttcattc tggctgacaa cgggaccact ggaaaatatg    960

gagcagaggt gaaacttcga agacaactgg aaaagcatat ttcactccag aagataaaca   1020

caagaatcgg tcaaggtgtt cctgtggtgg cactcatagt ggaaggagga cccaatgtga   1080

tctcgattgt tttggagtac cttcgagaca cccctcccgt gccagtggtt gtctgtgatg   1140

ggagtggacg ggcatcggac atcctggcct ttgggcataa atactcagaa gaaggcggac   1200

tgataaatga atctttgagg gaccagctgt tggtgactat acagaagact ttcacataca   1260

ctcgaaccca agctcagcat ctgttcatca tcctcatgga gtgcatgaag aagaaggaat   1320

tgattacggt atttcggatg ggatcagaag gacaccagga cattgatttg gctatcctga   1380

cagctttact caaaggagcc aatgcctcgg ccccagacca actgagctta gctttagcct   1440

ggaacagagt cgacatcgct cgcagccaga tctttattta cgggcaacag tggccggtgg   1500

gatctctgga gcaagccatg ttggatgcct tagttctgga cagagtggat tttgtgaaat   1560

tactcataga gaatggagta agcatgcacc gttttctcac catctccaga ctagaggaat   1620

tgtacaatac gagacatggg ccctcaaata cattgtacca cttggtcagg gatgtcaaaa   1680

aggggaacct gcccccagac tacagaatca gcctgattga catcggcctg gtgatcgagt   1740

acctgatggg cggggcttat cgctgcaact acacgcgcaa gcgcttccgg accctctacc   1800

acaacctctt cggccccaag agggatgata ttcccttgag gcgaggaaga aagacaacca   1860

agaaacgtga agaagaggtg gacattgact tggatgatcc tgagatcaac cacttcccct   1920

tccctttcca tgagctcatg gtgtgggctg ttctcatgaa gcggcagaag atggccctgt   1980

tcttctggca gcacggtgag gaggccatgg ccaaggccct ggtggcctgc aagctctgca   2040

aagccatggc tcatgaggcc tctgagaacg acatggttga cgacatttcc caggagctga   2100

atcacaattc cagagacttt ggccagctgg ctgtggagct cctggaccag tcctacaagc   2160

aggacgaaca gctggccatg aaactgctga cgtatgagct gaagaactgg agcaacgcca   2220

cgtgcctgca gcttgccgtg gctgccaaac accgcgactt catcgcgcac acgtgcagcc   2280

agatgctgct caccgacatg tggatgggcc ggctccgcat gcgcaagaac tcaggcctca   2340

aggtaattct gggaattcta cttcctcctt caattctcag cttggagttc aagaacaaag   2400

acgacatgcc ctatatgtct caggcccagg aaatccacct ccaagagaag gaggcagaag   2460

aaccagagaa gcccacaaag gaaaaagagg aagaggacat ggagctcaca gcaatgttgg   2520

gacgaaacaa cggggagtcc tccaggaaga aggatgaaga ggaagttcag agcaagcacc   2580

ggttaatccc cctcggcaga aaaatctatg aattctacaa tgcacccatc gtgaagttct   2640

ggttctacac actggcgtat atcggatacc tgatgctctt caactatatc gtgttagtga   2700

agatggaacg ctggccgtcc acccaggaat ggatcgtaat ctcctatatt ttcaccctgg   2760

gaatagaaaa gatgagagag attctgatgt cagagccagg gaagttgcta cagaaagtga   2820

aggtatggct gcaggagtac tggaatgtca cggacctcat cgccatcctt ctgttttctg   2880

tcggaatgat ccttcgtctc caagaccagc ccttcaggag tgacgggagg gtcatctact   2940

gcgtgaacat catttactgg tatatccgtc tcctagacat cttcggcgtg aacaagtatt   3000

tgggcccgta tgtaatgatg attggaaaaa tgatgataga catgatgtac tttgtcatca   3060

ttatgctggt ggttctgatg agctttgggg tcgccaggca agccatcctt tttcccaatg   3120

aggagccatc atggaaactg gccaagaaca tcttctacat gccctattgg atgatttatg   3180

gggaagtgtt tgcggaccag atagaccctc cctgtggaca gaatgagacc cgagaggatg   3240

gtaaaataat ccagctgcct ccctgcaaga caggagcttg gatcgtgccg gccatcatgg   3300

cctgctacct cttagtggca aacatcttgc tggtcaacct cctcattgct gtctttaaca   3360

atacattttt tgaagtaaaa tcgatatcca accaagtctg gaagtttcag aggtatcagc   3420

tcatcatgac tttccatgaa aggccagttc tgcccccacc actgatcatc ttcagccaca   3480

tgaccatgat attccagcac ctgtgctgcc gatggaggaa acacgagagc gacccggatg   3540

aaagggacta cggcctgaaa ctcttcataa ccgatgatga gctcaagaaa gtacatgact   3600

ttgaagagca atgcatagaa gaatacttca gagaaaagga tgatcggttc aactcatcta   3660

atgatgagag gatacgggtg acttcagaaa gggtggagaa catgtctatg cggctggagg   3720

aagtcaacga gagagagcac tccatgaagg cttcactcca gaccgtggac atccggctgg   3780

cgcagctgga agaccttatc gggcgcatgg ccacggccct ggagcgcctg acaggtctgg   3840

agcgggccga gtccaacaaa atccgctcga ggacctcgtc agactgcacg gacgccgcct   3900

acattgtccg tcagagcagc ttcaacagcc aggaagggaa caccttcaag ctccaagaga   3960

gtatagaccc tgcaggtgag gagaccatgt ccccaacttc tccaacctta atgccccgta   4020

tgcgaagcca ttctttctat tcggtcaata tgaaagacaa aggtggtata gaaaagttgg   4080

aaagtatttt taaagaaagg tccctgagcc tacaccgggc tactagttcc cactctgtag   4140

caaaagaacc caaagctcct gcagcccctg ccaacacctt ggccattgtt cctgattcca   4200

gaagaccatc atcgtgtata gacatctatg tctctgctat ggatgagctc cactgtgata   4260

tagaccctct ggacaattcc gtgaacatcc ttgggctggg cgagccaagc ttttcaactc   4320

cagtaccttc cacagcccct tcaagtagtg cctatgcaac acttgcaccc acagacagac   4380

ctccaagccg gagcattgat tttgaggaca tcacctccat ggacactaga tctttttctt   4440

cagactacac ccacctccca gaatgccaaa acccctggga ctcagagcct ccgatgtacc   4500

acaccattga gcgttccaaa agtagccgct acctagccac cacacccttt cttctagaag   4560

aggctcccat tgtgaaatct catagcttta tgttttcccc ctcaaggagc tattatgcca   4620

actttggggt gcctgtaaaa acagcagaat acacaagtat tacagactgt attgacacaa   4680

ggtgtgtcaa tgcccctcaa gcaattgcgg acagagctgc cttccctgga ggtcttggag   4740

acaaagtgga ggacttaact tgctgccatc cagagcgaga agcagaactg agtcacccca   4800

gctctgacag tgaggagaat gaggccaaag gccgcagagc caccattgca atatcctccc   4860

aggagggtga taactcagag agaaccctgt ccaacaacat cactgttccc aagatagagc   4920

gcgccaacag ctactcggca gaggagccaa gtgcgccata tgcacacacc aggaagagct   4980

tctccatcag tgacaaactc gacaggcagc ggaacacagc aagcctgcga aatcccttcc   5040

agagaagcaa gtcctccaag ccggagggcc gaggggacag cctgtccatg aggagactgt   5100

ccagaacatc ggctttccaa agctttgaaa gcaagcacaa ctaaaccttc ttaatatccg   5160

ccacagaagg ctcaagaatc cagccctaaa attctctcca actccagttt ttcccctttc   5220

cttgaatcat acctgcttta ttcttagctg agcaaaacaa gcaatgcttt gggaggtgtt   5280

aactcaaagg tgacttctgg gccacagatc aagaaagcat ttgatctgac ccagtgccag   5340

acacagggga tttaaggcat gttcacactt gctgggcagg gagggggaag agagggagaa   5400

ggaagggtta gagatgaatg tgtatccgca gtcacagcag aaagccatga gagcagggga   5460

aacaaggggc ttcgagcacg ctccatgcca ggaggcatct gttgatttct gaccattatc   5520

aagagttgta ggatgcaggg ctaaattgca aaataaaata aaatagccag cgtacacaat   5580

gagatattct aaacttccat tctgttttct tttcacattg gctccatcac tggtgactga   5640

tgaagagcat cctctttatt cagtataagc cggcagcaag cagttctacc taacgtccca   5700

catccttctc atgccaacac ttctgtaatt gatcattata aagaaaaaac aaggtaacag   5760

tcatagttca cctgtctctt atctattcac ttctggtgcc acaactgttt atcctttttt   5820

gaagaaaata agggaacaga aatgcctttt tgtattgcaa tcgaaatgaa agaagagttg   5880

atgttaaaaa aacaaaagtc aagtgattta ttatatacag tgggcgttca agtctagtcg   5940

agcaagctca ggagaatgta attaaataat tttatatttt ttaatttatt ttgtatctca   6000

cctgtcatgg atgaattcat tcactgaata tgtaatattg aacttaaaaa aaaaaaaaaa   6060

aaaacagtgg acagaactag cctgaaattg ccatgtggga tgttctgttc tcaccgttca   6120

tgtcgtgtgt tgtgctgctg tgtgaccgtc atcatttgca tggctccacc acgtcctcct   6180

gaacacctcc aagacgtaac tgccaatttt tcacaccact catcacatga ccattttgta   6240

tatgaatata tggttatatg tggatatttt catacctaga gttttgccat ctaatctgag   6300

ctcagcataa atttaattgg agtttttcaa gggctggtat cttttctatg gaaatgttcc   6360

aaagtacttt ttaaggaagt ttcaaaacta taaataacct tagatttgac tgggagtttg   6420

gtatcaaccc aaagccatca gttgcaagca taccatgaat atttttctta tagacagagc   6480

tataaaaaaa gatacagtag accaaaatag aaagcaaata aaccatataa agagttctat   6540

agtatatgcc acttatacac atgtatatgc atttatgcag agacacatat ttatatataa   6600

aataaatgga cataaagagc ttt                                           6623


<210>  2459
<211>  1544
<212>  PRT
<213>  Homo sapiens

<400>  2459


Met Tyr Val Arg Val Ser Phe Asp Thr Lys Pro Asp Leu Leu Leu His 
1               5                   10                  15      


Leu Met Thr Lys Glu Trp Gln Leu Glu Leu Pro Lys Leu Leu Ile Ser 
            20                  25                  30          


Val His Gly Gly Leu Gln Asn Phe Glu Leu Gln Pro Lys Leu Lys Gln 
        35                  40                  45              


Val Phe Gly Lys Gly Leu Ile Lys Ala Ala Met Thr Thr Gly Ala Trp 
    50                  55                  60                  


Ile Phe Thr Gly Gly Val Asn Thr Gly Val Ile Arg His Val Gly Asp 
65                  70                  75                  80  


Ala Leu Lys Asp His Ala Ser Lys Ser Arg Gly Lys Ile Cys Thr Ile 
                85                  90                  95      


Gly Ile Ala Pro Trp Gly Ile Val Glu Asn Gln Glu Asp Leu Ile Gly 
            100                 105                 110         


Arg Asp Val Val Arg Pro Tyr Gln Thr Met Ser Asn Pro Met Ser Lys 
        115                 120                 125             


Leu Thr Val Leu Asn Ser Met His Ser His Phe Ile Leu Ala Asp Asn 
    130                 135                 140                 


Gly Thr Thr Gly Lys Tyr Gly Ala Glu Val Lys Leu Arg Arg Gln Leu 
145                 150                 155                 160 


Glu Lys His Ile Ser Leu Gln Lys Ile Asn Thr Arg Ile Gly Gln Gly 
                165                 170                 175     


Val Pro Val Val Ala Leu Ile Val Glu Gly Gly Pro Asn Val Ile Ser 
            180                 185                 190         


Ile Val Leu Glu Tyr Leu Arg Asp Thr Pro Pro Val Pro Val Val Val 
        195                 200                 205             


Cys Asp Gly Ser Gly Arg Ala Ser Asp Ile Leu Ala Phe Gly His Lys 
    210                 215                 220                 


Tyr Ser Glu Glu Gly Gly Leu Ile Asn Glu Ser Leu Arg Asp Gln Leu 
225                 230                 235                 240 


Leu Val Thr Ile Gln Lys Thr Phe Thr Tyr Thr Arg Thr Gln Ala Gln 
                245                 250                 255     


His Leu Phe Ile Ile Leu Met Glu Cys Met Lys Lys Lys Glu Leu Ile 
            260                 265                 270         


Thr Val Phe Arg Met Gly Ser Glu Gly His Gln Asp Ile Asp Leu Ala 
        275                 280                 285             


Ile Leu Thr Ala Leu Leu Lys Gly Ala Asn Ala Ser Ala Pro Asp Gln 
    290                 295                 300                 


Leu Ser Leu Ala Leu Ala Trp Asn Arg Val Asp Ile Ala Arg Ser Gln 
305                 310                 315                 320 


Ile Phe Ile Tyr Gly Gln Gln Trp Pro Val Gly Ser Leu Glu Gln Ala 
                325                 330                 335     


Met Leu Asp Ala Leu Val Leu Asp Arg Val Asp Phe Val Lys Leu Leu 
            340                 345                 350         


Ile Glu Asn Gly Val Ser Met His Arg Phe Leu Thr Ile Ser Arg Leu 
        355                 360                 365             


Glu Glu Leu Tyr Asn Thr Arg His Gly Pro Ser Asn Thr Leu Tyr His 
    370                 375                 380                 


Leu Val Arg Asp Val Lys Lys Gly Asn Leu Pro Pro Asp Tyr Arg Ile 
385                 390                 395                 400 


Ser Leu Ile Asp Ile Gly Leu Val Ile Glu Tyr Leu Met Gly Gly Ala 
                405                 410                 415     


Tyr Arg Cys Asn Tyr Thr Arg Lys Arg Phe Arg Thr Leu Tyr His Asn 
            420                 425                 430         


Leu Phe Gly Pro Lys Arg Asp Asp Ile Pro Leu Arg Arg Gly Arg Lys 
        435                 440                 445             


Thr Thr Lys Lys Arg Glu Glu Glu Val Asp Ile Asp Leu Asp Asp Pro 
    450                 455                 460                 


Glu Ile Asn His Phe Pro Phe Pro Phe His Glu Leu Met Val Trp Ala 
465                 470                 475                 480 


Val Leu Met Lys Arg Gln Lys Met Ala Leu Phe Phe Trp Gln His Gly 
                485                 490                 495     


Glu Glu Ala Met Ala Lys Ala Leu Val Ala Cys Lys Leu Cys Lys Ala 
            500                 505                 510         


Met Ala His Glu Ala Ser Glu Asn Asp Met Val Asp Asp Ile Ser Gln 
        515                 520                 525             


Glu Leu Asn His Asn Ser Arg Asp Phe Gly Gln Leu Ala Val Glu Leu 
    530                 535                 540                 


Leu Asp Gln Ser Tyr Lys Gln Asp Glu Gln Leu Ala Met Lys Leu Leu 
545                 550                 555                 560 


Thr Tyr Glu Leu Lys Asn Trp Ser Asn Ala Thr Cys Leu Gln Leu Ala 
                565                 570                 575     


Val Ala Ala Lys His Arg Asp Phe Ile Ala His Thr Cys Ser Gln Met 
            580                 585                 590         


Leu Leu Thr Asp Met Trp Met Gly Arg Leu Arg Met Arg Lys Asn Ser 
        595                 600                 605             


Gly Leu Lys Val Ile Leu Gly Ile Leu Leu Pro Pro Ser Ile Leu Ser 
    610                 615                 620                 


Leu Glu Phe Lys Asn Lys Asp Asp Met Pro Tyr Met Ser Gln Ala Gln 
625                 630                 635                 640 


Glu Ile His Leu Gln Glu Lys Glu Ala Glu Glu Pro Glu Lys Pro Thr 
                645                 650                 655     


Lys Glu Lys Glu Glu Glu Asp Met Glu Leu Thr Ala Met Leu Gly Arg 
            660                 665                 670         


Asn Asn Gly Glu Ser Ser Arg Lys Lys Asp Glu Glu Glu Val Gln Ser 
        675                 680                 685             


Lys His Arg Leu Ile Pro Leu Gly Arg Lys Ile Tyr Glu Phe Tyr Asn 
    690                 695                 700                 


Ala Pro Ile Val Lys Phe Trp Phe Tyr Thr Leu Ala Tyr Ile Gly Tyr 
705                 710                 715                 720 


Leu Met Leu Phe Asn Tyr Ile Val Leu Val Lys Met Glu Arg Trp Pro 
                725                 730                 735     


Ser Thr Gln Glu Trp Ile Val Ile Ser Tyr Ile Phe Thr Leu Gly Ile 
            740                 745                 750         


Glu Lys Met Arg Glu Ile Leu Met Ser Glu Pro Gly Lys Leu Leu Gln 
        755                 760                 765             


Lys Val Lys Val Trp Leu Gln Glu Tyr Trp Asn Val Thr Asp Leu Ile 
    770                 775                 780                 


Ala Ile Leu Leu Phe Ser Val Gly Met Ile Leu Arg Leu Gln Asp Gln 
785                 790                 795                 800 


Pro Phe Arg Ser Asp Gly Arg Val Ile Tyr Cys Val Asn Ile Ile Tyr 
                805                 810                 815     


Trp Tyr Ile Arg Leu Leu Asp Ile Phe Gly Val Asn Lys Tyr Leu Gly 
            820                 825                 830         


Pro Tyr Val Met Met Ile Gly Lys Met Met Ile Asp Met Met Tyr Phe 
        835                 840                 845             


Val Ile Ile Met Leu Val Val Leu Met Ser Phe Gly Val Ala Arg Gln 
    850                 855                 860                 


Ala Ile Leu Phe Pro Asn Glu Glu Pro Ser Trp Lys Leu Ala Lys Asn 
865                 870                 875                 880 


Ile Phe Tyr Met Pro Tyr Trp Met Ile Tyr Gly Glu Val Phe Ala Asp 
                885                 890                 895     


Gln Ile Asp Pro Pro Cys Gly Gln Asn Glu Thr Arg Glu Asp Gly Lys 
            900                 905                 910         


Ile Ile Gln Leu Pro Pro Cys Lys Thr Gly Ala Trp Ile Val Pro Ala 
        915                 920                 925             


Ile Met Ala Cys Tyr Leu Leu Val Ala Asn Ile Leu Leu Val Asn Leu 
    930                 935                 940                 


Leu Ile Ala Val Phe Asn Asn Thr Phe Phe Glu Val Lys Ser Ile Ser 
945                 950                 955                 960 


Asn Gln Val Trp Lys Phe Gln Arg Tyr Gln Leu Ile Met Thr Phe His 
                965                 970                 975     


Glu Arg Pro Val Leu Pro Pro Pro Leu Ile Ile Phe Ser His Met Thr 
            980                 985                 990         


Met Ile Phe Gln His Leu Cys Cys  Arg Trp Arg Lys His  Glu Ser Asp 
        995                 1000                 1005             


Pro Asp  Glu Arg Asp Tyr Gly  Leu Lys Leu Phe Ile  Thr Asp Asp 
    1010                 1015                 1020             


Glu Leu  Lys Lys Val His Asp  Phe Glu Glu Gln Cys  Ile Glu Glu 
    1025                 1030                 1035             


Tyr Phe  Arg Glu Lys Asp Asp  Arg Phe Asn Ser Ser  Asn Asp Glu 
    1040                 1045                 1050             


Arg Ile  Arg Val Thr Ser Glu  Arg Val Glu Asn Met  Ser Met Arg 
    1055                 1060                 1065             


Leu Glu  Glu Val Asn Glu Arg  Glu His Ser Met Lys  Ala Ser Leu 
    1070                 1075                 1080             


Gln Thr  Val Asp Ile Arg Leu  Ala Gln Leu Glu Asp  Leu Ile Gly 
    1085                 1090                 1095             


Arg Met  Ala Thr Ala Leu Glu  Arg Leu Thr Gly Leu  Glu Arg Ala 
    1100                 1105                 1110             


Glu Ser  Asn Lys Ile Arg Ser  Arg Thr Ser Ser Asp  Cys Thr Asp 
    1115                 1120                 1125             


Ala Ala  Tyr Ile Val Arg Gln  Ser Ser Phe Asn Ser  Gln Glu Gly 
    1130                 1135                 1140             


Asn Thr  Phe Lys Leu Gln Glu  Ser Ile Asp Pro Ala  Gly Glu Glu 
    1145                 1150                 1155             


Thr Met  Ser Pro Thr Ser Pro  Thr Leu Met Pro Arg  Met Arg Ser 
    1160                 1165                 1170             


His Ser  Phe Tyr Ser Val Asn  Met Lys Asp Lys Gly  Gly Ile Glu 
    1175                 1180                 1185             


Lys Leu  Glu Ser Ile Phe Lys  Glu Arg Ser Leu Ser  Leu His Arg 
    1190                 1195                 1200             


Ala Thr  Ser Ser His Ser Val  Ala Lys Glu Pro Lys  Ala Pro Ala 
    1205                 1210                 1215             


Ala Pro  Ala Asn Thr Leu Ala  Ile Val Pro Asp Ser  Arg Arg Pro 
    1220                 1225                 1230             


Ser Ser  Cys Ile Asp Ile Tyr  Val Ser Ala Met Asp  Glu Leu His 
    1235                 1240                 1245             


Cys Asp  Ile Asp Pro Leu Asp  Asn Ser Val Asn Ile  Leu Gly Leu 
    1250                 1255                 1260             


Gly Glu  Pro Ser Phe Ser Thr  Pro Val Pro Ser Thr  Ala Pro Ser 
    1265                 1270                 1275             


Ser Ser  Ala Tyr Ala Thr Leu  Ala Pro Thr Asp Arg  Pro Pro Ser 
    1280                 1285                 1290             


Arg Ser  Ile Asp Phe Glu Asp  Ile Thr Ser Met Asp  Thr Arg Ser 
    1295                 1300                 1305             


Phe Ser  Ser Asp Tyr Thr His  Leu Pro Glu Cys Gln  Asn Pro Trp 
    1310                 1315                 1320             


Asp Ser  Glu Pro Pro Met Tyr  His Thr Ile Glu Arg  Ser Lys Ser 
    1325                 1330                 1335             


Ser Arg  Tyr Leu Ala Thr Thr  Pro Phe Leu Leu Glu  Glu Ala Pro 
    1340                 1345                 1350             


Ile Val  Lys Ser His Ser Phe  Met Phe Ser Pro Ser  Arg Ser Tyr 
    1355                 1360                 1365             


Tyr Ala  Asn Phe Gly Val Pro  Val Lys Thr Ala Glu  Tyr Thr Ser 
    1370                 1375                 1380             


Ile Thr  Asp Cys Ile Asp Thr  Arg Cys Val Asn Ala  Pro Gln Ala 
    1385                 1390                 1395             


Ile Ala  Asp Arg Ala Ala Phe  Pro Gly Gly Leu Gly  Asp Lys Val 
    1400                 1405                 1410             


Glu Asp  Leu Thr Cys Cys His  Pro Glu Arg Glu Ala  Glu Leu Ser 
    1415                 1420                 1425             


His Pro  Ser Ser Asp Ser Glu  Glu Asn Glu Ala Lys  Gly Arg Arg 
    1430                 1435                 1440             


Ala Thr  Ile Ala Ile Ser Ser  Gln Glu Gly Asp Asn  Ser Glu Arg 
    1445                 1450                 1455             


Thr Leu  Ser Asn Asn Ile Thr  Val Pro Lys Ile Glu  Arg Ala Asn 
    1460                 1465                 1470             


Ser Tyr  Ser Ala Glu Glu Pro  Ser Ala Pro Tyr Ala  His Thr Arg 
    1475                 1480                 1485             


Lys Ser  Phe Ser Ile Ser Asp  Lys Leu Asp Arg Gln  Arg Asn Thr 
    1490                 1495                 1500             


Ala Ser  Leu Arg Asn Pro Phe  Gln Arg Ser Lys Ser  Ser Lys Pro 
    1505                 1510                 1515             


Glu Gly  Arg Gly Asp Ser Leu  Ser Met Arg Arg Leu  Ser Arg Thr 
    1520                 1525                 1530             


Ser Ala  Phe Gln Ser Phe Glu  Ser Lys His Asn 
    1535                 1540                 

<210>  2460
<211>  6653
<212>  DNA
<213>  Homo sapiens

<400>  2460
tagtgaggct aatcccgaag cagcacattc caaggggcta atctgcccaa gttcattgct     60

tacttgaaac gtctcttggg ggaagagccg aacaagtgac tttttttttc cagtgggcgg    120

tcataagagc attattaacg gaatgaccag ccctagctgc agcaaaatga aagcaacagg    180

agctgctccg gggactgctt ttgccagtac ccagaatcag tgctcaggct cagaaatcct    240

ggatagaaag agcattttat aaaagagaat gtgtccacat catacccagc accaaagacc    300

cccataggtg ttgctgtggg cgtctgatag gccagcatgt tggcctcacc cccagtatct    360

ccgtgcttca gaatgagaaa aatgaaagtc gcctctcccg aaatgacatc cagtctgaaa    420

agtggtccat cagcaaacac actcaactca gccctacgga tgcttttggg accattgagt    480

tccaaggagg tggccattcc aacaaagcca tgtatgtgcg agtatctttt gatacaaaac    540

ctgatctcct cttacacctg atgaccaagg aatggcagtt ggagcttccc aagcttctca    600

tctctgtcca tgggggcctg cagaactttg aactccagcc aaaactcaag caagtctttg    660

ggaaagggct catcaaagca gcaatgacaa ctggagcgtg gatattcact ggaggggtta    720

acacaggtgt tattcgtcat gttggcgatg ccttgaagga tcatgcctct aagtctcgag    780

gaaagatatg caccataggt attgccccct ggggaattgt ggaaaaccag gaggacctca    840

ttggaagaga tgttgtccgg ccataccaga ccatgtccaa tcccatgagc aagctcactg    900

ttctcaacag catgcattcc cacttcattc tggctgacaa cgggaccact ggaaaatatg    960

gagcagaggt gaaacttcga agacaactgg aaaagcatat ttcactccag aagataaaca   1020

caagaatcgg tcaaggtgtt cctgtggtgg cactcatagt ggaaggagga cccaatgtga   1080

tctcgattgt tttggagtac cttcgagaca cccctcccgt gccagtggtt gtctgtgatg   1140

ggagtggacg ggcatcggac atcctggcct ttgggcataa atactcagaa gaaggcggac   1200

tgataaatga atctttgagg gaccagctgt tggtgactat acagaagact ttcacataca   1260

ctcgaaccca agctcagcat ctgttcatca tcctcatgga gtgcatgaag aagaaggaat   1320

tgattacggt atttcggatg ggatcagaag gacaccagga cattgatttg gctatcctga   1380

cagctttact caaaggagcc aatgcctcgg ccccagacca actgagctta gctttagcct   1440

ggaacagagt cgacatcgct cgcagccaga tctttattta cgggcaacag tggccggtgg   1500

gatctctgga gcaagccatg ttggatgcct tagttctgga cagagtggat tttgtgaaat   1560

tactcataga gaatggagta agcatgcacc gttttctcac catctccaga ctagaggaat   1620

tgtacaatac gagacatggg ccctcaaata cattgtacca cttggtcagg gatgtcaaaa   1680

aggggaacct gcccccagac tacagaatca gcctgattga catcggcctg gtgatcgagt   1740

acctgatggg cggggcttat cgctgcaact acacgcgcaa gcgcttccgg accctctacc   1800

acaacctctt cggccccaag aggcccaaag ccttgaaact gctgggaatg gaggatgata   1860

ttcccttgag gcgaggaaga aagacaacca agaaacgtga agaagaggtg gacattgact   1920

tggatgatcc tgagatcaac cacttcccct tccctttcca tgagctcatg gtgtgggctg   1980

ttctcatgaa gcggcagaag atggccctgt tcttctggca gcacggtgag gaggccatgg   2040

ccaaggccct ggtggcctgc aagctctgca aagccatggc tcatgaggcc tctgagaacg   2100

acatggttga cgacatttcc caggagctga atcacaattc cagagacttt ggccagctgg   2160

ctgtggagct cctggaccag tcctacaagc aggacgaaca gctggccatg aaactgctga   2220

cgtatgagct gaagaactgg agcaacgcca cgtgcctgca gcttgccgtg gctgccaaac   2280

accgcgactt catcgcgcac acgtgcagcc agatgctgct caccgacatg tggatgggcc   2340

ggctccgcat gcgcaagaac tcaggcctca aggtaattct gggaattcta cttcctcctt   2400

caattctcag cttggagttc aagaacaaag acgacatgcc ctatatgtct caggcccagg   2460

aaatccacct ccaagagaag gaggcagaag aaccagagaa gcccacaaag gaaaaagagg   2520

aagaggacat ggagctcaca gcaatgttgg gacgaaacaa cggggagtcc tccaggaaga   2580

aggatgaaga ggaagttcag agcaagcacc ggttaatccc cctcggcaga aaaatctatg   2640

aattctacaa tgcacccatc gtgaagttct ggttctacac actggcgtat atcggatacc   2700

tgatgctctt caactatatc gtgttagtga agatggaacg ctggccgtcc acccaggaat   2760

ggatcgtaat ctcctatatt ttcaccctgg gaatagaaaa gatgagagag attctgatgt   2820

cagagccagg gaagttgcta cagaaagtga aggtatggct gcaggagtac tggaatgtca   2880

cggacctcat cgccatcctt ctgttttctg tcggaatgat ccttcgtctc caagaccagc   2940

ccttcaggag tgacgggagg gtcatctact gcgtgaacat catttactgg tatatccgtc   3000

tcctagacat cttcggcgtg aacaagtatt tgggcccgta tgtaatgatg attggaaaaa   3060

tgatgataga catgatgtac tttgtcatca ttatgctggt ggttctgatg agctttgggg   3120

tcgccaggca agccatcctt tttcccaatg aggagccatc atggaaactg gccaagaaca   3180

tcttctacat gccctattgg atgatttatg gggaagtgtt tgcggaccag atagaccctc   3240

cctgtggaca gaatgagacc cgagaggatg gtaaaataat ccagctgcct ccctgcaaga   3300

caggagcttg gatcgtgccg gccatcatgg cctgctacct cttagtggca aacatcttgc   3360

tggtcaacct cctcattgct gtctttaaca atacattttt tgaagtaaaa tcgatatcca   3420

accaagtctg gaagtttcag aggtatcagc tcatcatgac tttccatgaa aggccagttc   3480

tgcccccacc actgatcatc ttcagccaca tgaccatgat attccagcac ctgtgctgcc   3540

gatggaggaa acacgagagc gacccggatg aaagggacta cggcctgaaa ctcttcataa   3600

ccgatgatga gctcaagaaa gtacatgact ttgaagagca atgcatagaa gaatacttca   3660

gagaaaagga tgatcggttc aactcatcta atgatgagag gatacgggtg acttcagaaa   3720

gggtggagaa catgtctatg cggctggagg aagtcaacga gagagagcac tccatgaagg   3780

cttcactcca gaccgtggac atccggctgg cgcagctgga agaccttatc gggcgcatgg   3840

ccacggccct ggagcgcctg acaggtctgg agcgggccga gtccaacaaa atccgctcga   3900

ggacctcgtc agactgcacg gacgccgcct acattgtccg tcagagcagc ttcaacagcc   3960

aggaagggaa caccttcaag ctccaagaga gtatagaccc tgcaggtgag gagaccatgt   4020

ccccaacttc tccaacctta atgccccgta tgcgaagcca ttctttctat tcggtcaata   4080

tgaaagacaa aggtggtata gaaaagttgg aaagtatttt taaagaaagg tccctgagcc   4140

tacaccgggc tactagttcc cactctgtag caaaagaacc caaagctcct gcagcccctg   4200

ccaacacctt ggccattgtt cctgattcca gaagaccatc atcgtgtata gacatctatg   4260

tctctgctat ggatgagctc cactgtgata tagaccctct ggacaattcc gtgaacatcc   4320

ttgggctggg cgagccaagc ttttcaactc cagtaccttc cacagcccct tcaagtagtg   4380

cctatgcaac acttgcaccc acagacagac ctccaagccg gagcattgat tttgaggaca   4440

tcacctccat ggacactaga tctttttctt cagactacac ccacctccca gaatgccaaa   4500

acccctggga ctcagagcct ccgatgtacc acaccattga gcgttccaaa agtagccgct   4560

acctagccac cacacccttt cttctagaag aggctcccat tgtgaaatct catagcttta   4620

tgttttcccc ctcaaggagc tattatgcca actttggggt gcctgtaaaa acagcagaat   4680

acacaagtat tacagactgt attgacacaa ggtgtgtcaa tgcccctcaa gcaattgcgg   4740

acagagctgc cttccctgga ggtcttggag acaaagtgga ggacttaact tgctgccatc   4800

cagagcgaga agcagaactg agtcacccca gctctgacag tgaggagaat gaggccaaag   4860

gccgcagagc caccattgca atatcctccc aggagggtga taactcagag agaaccctgt   4920

ccaacaacat cactgttccc aagatagagc gcgccaacag ctactcggca gaggagccaa   4980

gtgcgccata tgcacacacc aggaagagct tctccatcag tgacaaactc gacaggcagc   5040

ggaacacagc aagcctgcga aatcccttcc agagaagcaa gtcctccaag ccggagggcc   5100

gaggggacag cctgtccatg aggagactgt ccagaacatc ggctttccaa agctttgaaa   5160

gcaagcacaa ctaaaccttc ttaatatccg ccacagaagg ctcaagaatc cagccctaaa   5220

attctctcca actccagttt ttcccctttc cttgaatcat acctgcttta ttcttagctg   5280

agcaaaacaa gcaatgcttt gggaggtgtt aactcaaagg tgacttctgg gccacagatc   5340

aagaaagcat ttgatctgac ccagtgccag acacagggga tttaaggcat gttcacactt   5400

gctgggcagg gagggggaag agagggagaa ggaagggtta gagatgaatg tgtatccgca   5460

gtcacagcag aaagccatga gagcagggga aacaaggggc ttcgagcacg ctccatgcca   5520

ggaggcatct gttgatttct gaccattatc aagagttgta ggatgcaggg ctaaattgca   5580

aaataaaata aaatagccag cgtacacaat gagatattct aaacttccat tctgttttct   5640

tttcacattg gctccatcac tggtgactga tgaagagcat cctctttatt cagtataagc   5700

cggcagcaag cagttctacc taacgtccca catccttctc atgccaacac ttctgtaatt   5760

gatcattata aagaaaaaac aaggtaacag tcatagttca cctgtctctt atctattcac   5820

ttctggtgcc acaactgttt atcctttttt gaagaaaata agggaacaga aatgcctttt   5880

tgtattgcaa tcgaaatgaa agaagagttg atgttaaaaa aacaaaagtc aagtgattta   5940

ttatatacag tgggcgttca agtctagtcg agcaagctca ggagaatgta attaaataat   6000

tttatatttt ttaatttatt ttgtatctca cctgtcatgg atgaattcat tcactgaata   6060

tgtaatattg aacttaaaaa aaaaaaaaaa aaaacagtgg acagaactag cctgaaattg   6120

ccatgtggga tgttctgttc tcaccgttca tgtcgtgtgt tgtgctgctg tgtgaccgtc   6180

atcatttgca tggctccacc acgtcctcct gaacacctcc aagacgtaac tgccaatttt   6240

tcacaccact catcacatga ccattttgta tatgaatata tggttatatg tggatatttt   6300

catacctaga gttttgccat ctaatctgag ctcagcataa atttaattgg agtttttcaa   6360

gggctggtat cttttctatg gaaatgttcc aaagtacttt ttaaggaagt ttcaaaacta   6420

taaataacct tagatttgac tgggagtttg gtatcaaccc aaagccatca gttgcaagca   6480

taccatgaat atttttctta tagacagagc tataaaaaaa gatacagtag accaaaatag   6540

aaagcaaata aaccatataa agagttctat agtatatgcc acttatacac atgtatatgc   6600

atttatgcag agacacatat ttatatataa aataaatgga cataaagagc ttt          6653


<210>  2461
<211>  1554
<212>  PRT
<213>  Homo sapiens

<400>  2461


Met Tyr Val Arg Val Ser Phe Asp Thr Lys Pro Asp Leu Leu Leu His 
1               5                   10                  15      


Leu Met Thr Lys Glu Trp Gln Leu Glu Leu Pro Lys Leu Leu Ile Ser 
            20                  25                  30          


Val His Gly Gly Leu Gln Asn Phe Glu Leu Gln Pro Lys Leu Lys Gln 
        35                  40                  45              


Val Phe Gly Lys Gly Leu Ile Lys Ala Ala Met Thr Thr Gly Ala Trp 
    50                  55                  60                  


Ile Phe Thr Gly Gly Val Asn Thr Gly Val Ile Arg His Val Gly Asp 
65                  70                  75                  80  


Ala Leu Lys Asp His Ala Ser Lys Ser Arg Gly Lys Ile Cys Thr Ile 
                85                  90                  95      


Gly Ile Ala Pro Trp Gly Ile Val Glu Asn Gln Glu Asp Leu Ile Gly 
            100                 105                 110         


Arg Asp Val Val Arg Pro Tyr Gln Thr Met Ser Asn Pro Met Ser Lys 
        115                 120                 125             


Leu Thr Val Leu Asn Ser Met His Ser His Phe Ile Leu Ala Asp Asn 
    130                 135                 140                 


Gly Thr Thr Gly Lys Tyr Gly Ala Glu Val Lys Leu Arg Arg Gln Leu 
145                 150                 155                 160 


Glu Lys His Ile Ser Leu Gln Lys Ile Asn Thr Arg Ile Gly Gln Gly 
                165                 170                 175     


Val Pro Val Val Ala Leu Ile Val Glu Gly Gly Pro Asn Val Ile Ser 
            180                 185                 190         


Ile Val Leu Glu Tyr Leu Arg Asp Thr Pro Pro Val Pro Val Val Val 
        195                 200                 205             


Cys Asp Gly Ser Gly Arg Ala Ser Asp Ile Leu Ala Phe Gly His Lys 
    210                 215                 220                 


Tyr Ser Glu Glu Gly Gly Leu Ile Asn Glu Ser Leu Arg Asp Gln Leu 
225                 230                 235                 240 


Leu Val Thr Ile Gln Lys Thr Phe Thr Tyr Thr Arg Thr Gln Ala Gln 
                245                 250                 255     


His Leu Phe Ile Ile Leu Met Glu Cys Met Lys Lys Lys Glu Leu Ile 
            260                 265                 270         


Thr Val Phe Arg Met Gly Ser Glu Gly His Gln Asp Ile Asp Leu Ala 
        275                 280                 285             


Ile Leu Thr Ala Leu Leu Lys Gly Ala Asn Ala Ser Ala Pro Asp Gln 
    290                 295                 300                 


Leu Ser Leu Ala Leu Ala Trp Asn Arg Val Asp Ile Ala Arg Ser Gln 
305                 310                 315                 320 


Ile Phe Ile Tyr Gly Gln Gln Trp Pro Val Gly Ser Leu Glu Gln Ala 
                325                 330                 335     


Met Leu Asp Ala Leu Val Leu Asp Arg Val Asp Phe Val Lys Leu Leu 
            340                 345                 350         


Ile Glu Asn Gly Val Ser Met His Arg Phe Leu Thr Ile Ser Arg Leu 
        355                 360                 365             


Glu Glu Leu Tyr Asn Thr Arg His Gly Pro Ser Asn Thr Leu Tyr His 
    370                 375                 380                 


Leu Val Arg Asp Val Lys Lys Gly Asn Leu Pro Pro Asp Tyr Arg Ile 
385                 390                 395                 400 


Ser Leu Ile Asp Ile Gly Leu Val Ile Glu Tyr Leu Met Gly Gly Ala 
                405                 410                 415     


Tyr Arg Cys Asn Tyr Thr Arg Lys Arg Phe Arg Thr Leu Tyr His Asn 
            420                 425                 430         


Leu Phe Gly Pro Lys Arg Pro Lys Ala Leu Lys Leu Leu Gly Met Glu 
        435                 440                 445             


Asp Asp Ile Pro Leu Arg Arg Gly Arg Lys Thr Thr Lys Lys Arg Glu 
    450                 455                 460                 


Glu Glu Val Asp Ile Asp Leu Asp Asp Pro Glu Ile Asn His Phe Pro 
465                 470                 475                 480 


Phe Pro Phe His Glu Leu Met Val Trp Ala Val Leu Met Lys Arg Gln 
                485                 490                 495     


Lys Met Ala Leu Phe Phe Trp Gln His Gly Glu Glu Ala Met Ala Lys 
            500                 505                 510         


Ala Leu Val Ala Cys Lys Leu Cys Lys Ala Met Ala His Glu Ala Ser 
        515                 520                 525             


Glu Asn Asp Met Val Asp Asp Ile Ser Gln Glu Leu Asn His Asn Ser 
    530                 535                 540                 


Arg Asp Phe Gly Gln Leu Ala Val Glu Leu Leu Asp Gln Ser Tyr Lys 
545                 550                 555                 560 


Gln Asp Glu Gln Leu Ala Met Lys Leu Leu Thr Tyr Glu Leu Lys Asn 
                565                 570                 575     


Trp Ser Asn Ala Thr Cys Leu Gln Leu Ala Val Ala Ala Lys His Arg 
            580                 585                 590         


Asp Phe Ile Ala His Thr Cys Ser Gln Met Leu Leu Thr Asp Met Trp 
        595                 600                 605             


Met Gly Arg Leu Arg Met Arg Lys Asn Ser Gly Leu Lys Val Ile Leu 
    610                 615                 620                 


Gly Ile Leu Leu Pro Pro Ser Ile Leu Ser Leu Glu Phe Lys Asn Lys 
625                 630                 635                 640 


Asp Asp Met Pro Tyr Met Ser Gln Ala Gln Glu Ile His Leu Gln Glu 
                645                 650                 655     


Lys Glu Ala Glu Glu Pro Glu Lys Pro Thr Lys Glu Lys Glu Glu Glu 
            660                 665                 670         


Asp Met Glu Leu Thr Ala Met Leu Gly Arg Asn Asn Gly Glu Ser Ser 
        675                 680                 685             


Arg Lys Lys Asp Glu Glu Glu Val Gln Ser Lys His Arg Leu Ile Pro 
    690                 695                 700                 


Leu Gly Arg Lys Ile Tyr Glu Phe Tyr Asn Ala Pro Ile Val Lys Phe 
705                 710                 715                 720 


Trp Phe Tyr Thr Leu Ala Tyr Ile Gly Tyr Leu Met Leu Phe Asn Tyr 
                725                 730                 735     


Ile Val Leu Val Lys Met Glu Arg Trp Pro Ser Thr Gln Glu Trp Ile 
            740                 745                 750         


Val Ile Ser Tyr Ile Phe Thr Leu Gly Ile Glu Lys Met Arg Glu Ile 
        755                 760                 765             


Leu Met Ser Glu Pro Gly Lys Leu Leu Gln Lys Val Lys Val Trp Leu 
    770                 775                 780                 


Gln Glu Tyr Trp Asn Val Thr Asp Leu Ile Ala Ile Leu Leu Phe Ser 
785                 790                 795                 800 


Val Gly Met Ile Leu Arg Leu Gln Asp Gln Pro Phe Arg Ser Asp Gly 
                805                 810                 815     


Arg Val Ile Tyr Cys Val Asn Ile Ile Tyr Trp Tyr Ile Arg Leu Leu 
            820                 825                 830         


Asp Ile Phe Gly Val Asn Lys Tyr Leu Gly Pro Tyr Val Met Met Ile 
        835                 840                 845             


Gly Lys Met Met Ile Asp Met Met Tyr Phe Val Ile Ile Met Leu Val 
    850                 855                 860                 


Val Leu Met Ser Phe Gly Val Ala Arg Gln Ala Ile Leu Phe Pro Asn 
865                 870                 875                 880 


Glu Glu Pro Ser Trp Lys Leu Ala Lys Asn Ile Phe Tyr Met Pro Tyr 
                885                 890                 895     


Trp Met Ile Tyr Gly Glu Val Phe Ala Asp Gln Ile Asp Pro Pro Cys 
            900                 905                 910         


Gly Gln Asn Glu Thr Arg Glu Asp Gly Lys Ile Ile Gln Leu Pro Pro 
        915                 920                 925             


Cys Lys Thr Gly Ala Trp Ile Val Pro Ala Ile Met Ala Cys Tyr Leu 
    930                 935                 940                 


Leu Val Ala Asn Ile Leu Leu Val Asn Leu Leu Ile Ala Val Phe Asn 
945                 950                 955                 960 


Asn Thr Phe Phe Glu Val Lys Ser Ile Ser Asn Gln Val Trp Lys Phe 
                965                 970                 975     


Gln Arg Tyr Gln Leu Ile Met Thr Phe His Glu Arg Pro Val Leu Pro 
            980                 985                 990         


Pro Pro Leu Ile Ile Phe Ser His  Met Thr Met Ile Phe  Gln His Leu 
        995                 1000                 1005             


Cys Cys  Arg Trp Arg Lys His  Glu Ser Asp Pro Asp  Glu Arg Asp 
    1010                 1015                 1020             


Tyr Gly  Leu Lys Leu Phe Ile  Thr Asp Asp Glu Leu  Lys Lys Val 
    1025                 1030                 1035             


His Asp  Phe Glu Glu Gln Cys  Ile Glu Glu Tyr Phe  Arg Glu Lys 
    1040                 1045                 1050             


Asp Asp  Arg Phe Asn Ser Ser  Asn Asp Glu Arg Ile  Arg Val Thr 
    1055                 1060                 1065             


Ser Glu  Arg Val Glu Asn Met  Ser Met Arg Leu Glu  Glu Val Asn 
    1070                 1075                 1080             


Glu Arg  Glu His Ser Met Lys  Ala Ser Leu Gln Thr  Val Asp Ile 
    1085                 1090                 1095             


Arg Leu  Ala Gln Leu Glu Asp  Leu Ile Gly Arg Met  Ala Thr Ala 
    1100                 1105                 1110             


Leu Glu  Arg Leu Thr Gly Leu  Glu Arg Ala Glu Ser  Asn Lys Ile 
    1115                 1120                 1125             


Arg Ser  Arg Thr Ser Ser Asp  Cys Thr Asp Ala Ala  Tyr Ile Val 
    1130                 1135                 1140             


Arg Gln  Ser Ser Phe Asn Ser  Gln Glu Gly Asn Thr  Phe Lys Leu 
    1145                 1150                 1155             


Gln Glu  Ser Ile Asp Pro Ala  Gly Glu Glu Thr Met  Ser Pro Thr 
    1160                 1165                 1170             


Ser Pro  Thr Leu Met Pro Arg  Met Arg Ser His Ser  Phe Tyr Ser 
    1175                 1180                 1185             


Val Asn  Met Lys Asp Lys Gly  Gly Ile Glu Lys Leu  Glu Ser Ile 
    1190                 1195                 1200             


Phe Lys  Glu Arg Ser Leu Ser  Leu His Arg Ala Thr  Ser Ser His 
    1205                 1210                 1215             


Ser Val  Ala Lys Glu Pro Lys  Ala Pro Ala Ala Pro  Ala Asn Thr 
    1220                 1225                 1230             


Leu Ala  Ile Val Pro Asp Ser  Arg Arg Pro Ser Ser  Cys Ile Asp 
    1235                 1240                 1245             


Ile Tyr  Val Ser Ala Met Asp  Glu Leu His Cys Asp  Ile Asp Pro 
    1250                 1255                 1260             


Leu Asp  Asn Ser Val Asn Ile  Leu Gly Leu Gly Glu  Pro Ser Phe 
    1265                 1270                 1275             


Ser Thr  Pro Val Pro Ser Thr  Ala Pro Ser Ser Ser  Ala Tyr Ala 
    1280                 1285                 1290             


Thr Leu  Ala Pro Thr Asp Arg  Pro Pro Ser Arg Ser  Ile Asp Phe 
    1295                 1300                 1305             


Glu Asp  Ile Thr Ser Met Asp  Thr Arg Ser Phe Ser  Ser Asp Tyr 
    1310                 1315                 1320             


Thr His  Leu Pro Glu Cys Gln  Asn Pro Trp Asp Ser  Glu Pro Pro 
    1325                 1330                 1335             


Met Tyr  His Thr Ile Glu Arg  Ser Lys Ser Ser Arg  Tyr Leu Ala 
    1340                 1345                 1350             


Thr Thr  Pro Phe Leu Leu Glu  Glu Ala Pro Ile Val  Lys Ser His 
    1355                 1360                 1365             


Ser Phe  Met Phe Ser Pro Ser  Arg Ser Tyr Tyr Ala  Asn Phe Gly 
    1370                 1375                 1380             


Val Pro  Val Lys Thr Ala Glu  Tyr Thr Ser Ile Thr  Asp Cys Ile 
    1385                 1390                 1395             


Asp Thr  Arg Cys Val Asn Ala  Pro Gln Ala Ile Ala  Asp Arg Ala 
    1400                 1405                 1410             


Ala Phe  Pro Gly Gly Leu Gly  Asp Lys Val Glu Asp  Leu Thr Cys 
    1415                 1420                 1425             


Cys His  Pro Glu Arg Glu Ala  Glu Leu Ser His Pro  Ser Ser Asp 
    1430                 1435                 1440             


Ser Glu  Glu Asn Glu Ala Lys  Gly Arg Arg Ala Thr  Ile Ala Ile 
    1445                 1450                 1455             


Ser Ser  Gln Glu Gly Asp Asn  Ser Glu Arg Thr Leu  Ser Asn Asn 
    1460                 1465                 1470             


Ile Thr  Val Pro Lys Ile Glu  Arg Ala Asn Ser Tyr  Ser Ala Glu 
    1475                 1480                 1485             


Glu Pro  Ser Ala Pro Tyr Ala  His Thr Arg Lys Ser  Phe Ser Ile 
    1490                 1495                 1500             


Ser Asp  Lys Leu Asp Arg Gln  Arg Asn Thr Ala Ser  Leu Arg Asn 
    1505                 1510                 1515             


Pro Phe  Gln Arg Ser Lys Ser  Ser Lys Pro Glu Gly  Arg Gly Asp 
    1520                 1525                 1530             


Ser Leu  Ser Met Arg Arg Leu  Ser Arg Thr Ser Ala  Phe Gln Ser 
    1535                 1540                 1545             


Phe Glu  Ser Lys His Asn 
    1550                 

<210>  2462
<211>  6659
<212>  DNA
<213>  Homo sapiens

<400>  2462
tagtgaggct aatcccgaag cagcacattc caaggggcta atctgcccaa gttcattgct     60

tacttgaaac gtctcttggg ggaagagccg aacaagtgac tttttttttc cagtgggcgg    120

tcataagagc attattaacg gaatgaccag ccctagctgc agcaaaatga aagcaacagg    180

agctgctccg gggactgctt ttgccagtac ccagaatcag tgctcaggct cagaaatcct    240

ggatagaaag agcattttat aaaagagaat gtgtccacat catacccagc accaaagacc    300

cccataggtg ttgctgtggg cgtctgatag gccagcatgt tggcctcacc cccagtatct    360

ccgtgcttca gaatgagaaa aatgaaagtc gcctctcccg aaatgacatc cagtctgaaa    420

agtggtccat cagcaaacac actcaactca gccctacgga tgcttttggg accattgagt    480

tccaaggagg tggccattcc aacaaagcca tgtatgtgcg agtatctttt gatacaaaac    540

ctgatctcct cttacacctg atgaccaagg aatggcagtt ggagcttccc aagcttctca    600

tctctgtcca tgggggcctg cagaactttg aactccagcc aaaactcaag caagtctttg    660

ggaaagggct catcaaagca gcaatgacaa ctggagcgtg gatattcact ggaggggtta    720

acacaggtgt tattcgtcat gttggcgatg ccttgaagga tcatgcctct aagtctcgag    780

gaaagatatg caccataggt attgccccct ggggaattgt ggaaaaccag gaggacctca    840

ttggaagaga tgttgtccgg ccataccaga ccatgtccaa tcccatgagc aagctcactg    900

ttctcaacag catgcattcc cacttcattc tggctgacaa cgggaccact ggaaaatatg    960

gagcagaggt gaaacttcga agacaactgg aaaagcatat ttcactccag aagataaaca   1020

caagaatcgg tcaaggtgtt cctgtggtgg cactcatagt ggaaggagga cccaatgtga   1080

tctcgattgt tttggagtac cttcgagaca cccctcccgt gccagtggtt gtctgtgatg   1140

ggagtggacg ggcatcggac atcctggcct ttgggcataa atactcagaa gaaggcggac   1200

tgataaatga atctttgagg gaccagctgt tggtgactat acagaagact ttcacataca   1260

ctcgaaccca agctcagcat ctgttcatca tcctcatgga gtgcatgaag aagaaggaat   1320

tgattacggt atttcggatg ggatcagaag gacaccagga cattgatttg gctatcctga   1380

cagctttact caaaggagcc aatgcctcgg ccccagacca actgagctta gctttagcct   1440

ggaacagagt cgacatcgct cgcagccaga tctttattta cgggcaacag tggccggtgg   1500

gatctctgga gcaagccatg ttggatgcct tagttctgga cagagtggat tttgtgaaat   1560

tactcataga gaatggagta agcatgcacc gttttctcac catctccaga ctagaggaat   1620

tgtacaatac gagacatggg ccctcaaata cattgtacca cttggtcagg gatgtcaaaa   1680

agcgagagta tccaggtttc ggttggatct attttaaggg gaacctgccc ccagactaca   1740

gaatcagcct gattgacatc ggcctggtga tcgagtacct gatgggcggg gcttatcgct   1800

gcaactacac gcgcaagcgc ttccggaccc tctaccacaa cctcttcggc cccaagaggg   1860

atgatattcc cttgaggcga ggaagaaaga caaccaagaa acgtgaagaa gaggtggaca   1920

ttgacttgga tgatcctgag atcaaccact tccccttccc tttccatgag ctcatggtgt   1980

gggctgttct catgaagcgg cagaagatgg ccctgttctt ctggcagcac ggtgaggagg   2040

ccatggccaa ggccctggtg gcctgcaagc tctgcaaagc catggctcat gaggcctctg   2100

agaacgacat ggttgacgac atttcccagg agctgaatca caattccaga gactttggcc   2160

agctggctgt ggagctcctg gaccagtcct acaagcagga cgaacagctg gccatgaaac   2220

tgctgacgta tgagctgaag aactggagca acgccacgtg cctgcagctt gccgtggctg   2280

ccaaacaccg cgacttcatc gcgcacacgt gcagccagat gctgctcacc gacatgtgga   2340

tgggccggct ccgcatgcgc aagaactcag gcctcaaggt aattctggga attctacttc   2400

ctccttcaat tctcagcttg gagttcaaga acaaagacga catgccctat atgtctcagg   2460

cccaggaaat ccacctccaa gagaaggagg cagaagaacc agagaagccc acaaaggaaa   2520

aagaggaaga ggacatggag ctcacagcaa tgttgggacg aaacaacggg gagtcctcca   2580

ggaagaagga tgaagaggaa gttcagagca agcaccggtt aatccccctc ggcagaaaaa   2640

tctatgaatt ctacaatgca cccatcgtga agttctggtt ctacacactg gcgtatatcg   2700

gatacctgat gctcttcaac tatatcgtgt tagtgaagat ggaacgctgg ccgtccaccc   2760

aggaatggat cgtaatctcc tatattttca ccctgggaat agaaaagatg agagagattc   2820

tgatgtcaga gccagggaag ttgctacaga aagtgaaggt atggctgcag gagtactgga   2880

atgtcacgga cctcatcgcc atccttctgt tttctgtcgg aatgatcctt cgtctccaag   2940

accagccctt caggagtgac gggagggtca tctactgcgt gaacatcatt tactggtata   3000

tccgtctcct agacatcttc ggcgtgaaca agtatttggg cccgtatgta atgatgattg   3060

gaaaaatgat gatagacatg atgtactttg tcatcattat gctggtggtt ctgatgagct   3120

ttggggtcgc caggcaagcc atcctttttc ccaatgagga gccatcatgg aaactggcca   3180

agaacatctt ctacatgccc tattggatga tttatgggga agtgtttgcg gaccagatag   3240

accctccctg tggacagaat gagacccgag aggatggtaa aataatccag ctgcctccct   3300

gcaagacagg agcttggatc gtgccggcca tcatggcctg ctacctctta gtggcaaaca   3360

tcttgctggt caacctcctc attgctgtct ttaacaatac attttttgaa gtaaaatcga   3420

tatccaacca agtctggaag tttcagaggt atcagctcat catgactttc catgaaaggc   3480

cagttctgcc cccaccactg atcatcttca gccacatgac catgatattc cagcacctgt   3540

gctgccgatg gaggaaacac gagagcgacc cggatgaaag ggactacggc ctgaaactct   3600

tcataaccga tgatgagctc aagaaagtac atgactttga agagcaatgc atagaagaat   3660

acttcagaga aaaggatgat cggttcaact catctaatga tgagaggata cgggtgactt   3720

cagaaagggt ggagaacatg tctatgcggc tggaggaagt caacgagaga gagcactcca   3780

tgaaggcttc actccagacc gtggacatcc ggctggcgca gctggaagac cttatcgggc   3840

gcatggccac ggccctggag cgcctgacag gtctggagcg ggccgagtcc aacaaaatcc   3900

gctcgaggac ctcgtcagac tgcacggacg ccgcctacat tgtccgtcag agcagcttca   3960

acagccagga agggaacacc ttcaagctcc aagagagtat agaccctgca ggtgaggaga   4020

ccatgtcccc aacttctcca accttaatgc cccgtatgcg aagccattct ttctattcgg   4080

tcaatatgaa agacaaaggt ggtatagaaa agttggaaag tatttttaaa gaaaggtccc   4140

tgagcctaca ccgggctact agttcccact ctgtagcaaa agaacccaaa gctcctgcag   4200

cccctgccaa caccttggcc attgttcctg attccagaag accatcatcg tgtatagaca   4260

tctatgtctc tgctatggat gagctccact gtgatataga ccctctggac aattccgtga   4320

acatccttgg gctgggcgag ccaagctttt caactccagt accttccaca gccccttcaa   4380

gtagtgccta tgcaacactt gcacccacag acagacctcc aagccggagc attgattttg   4440

aggacatcac ctccatggac actagatctt tttcttcaga ctacacccac ctcccagaat   4500

gccaaaaccc ctgggactca gagcctccga tgtaccacac cattgagcgt tccaaaagta   4560

gccgctacct agccaccaca ccctttcttc tagaagaggc tcccattgtg aaatctcata   4620

gctttatgtt ttccccctca aggagctatt atgccaactt tggggtgcct gtaaaaacag   4680

cagaatacac aagtattaca gactgtattg acacaaggtg tgtcaatgcc cctcaagcaa   4740

ttgcggacag agctgccttc cctggaggtc ttggagacaa agtggaggac ttaacttgct   4800

gccatccaga gcgagaagca gaactgagtc accccagctc tgacagtgag gagaatgagg   4860

ccaaaggccg cagagccacc attgcaatat cctcccagga gggtgataac tcagagagaa   4920

ccctgtccaa caacatcact gttcccaaga tagagcgcgc caacagctac tcggcagagg   4980

agccaagtgc gccatatgca cacaccagga agagcttctc catcagtgac aaactcgaca   5040

ggcagcggaa cacagcaagc ctgcgaaatc ccttccagag aagcaagtcc tccaagccgg   5100

agggccgagg ggacagcctg tccatgagga gactgtccag aacatcggct ttccaaagct   5160

ttgaaagcaa gcacaactaa accttcttaa tatccgccac agaaggctca agaatccagc   5220

cctaaaattc tctccaactc cagtttttcc cctttccttg aatcatacct gctttattct   5280

tagctgagca aaacaagcaa tgctttggga ggtgttaact caaaggtgac ttctgggcca   5340

cagatcaaga aagcatttga tctgacccag tgccagacac aggggattta aggcatgttc   5400

acacttgctg ggcagggagg gggaagagag ggagaaggaa gggttagaga tgaatgtgta   5460

tccgcagtca cagcagaaag ccatgagagc aggggaaaca aggggcttcg agcacgctcc   5520

atgccaggag gcatctgttg atttctgacc attatcaaga gttgtaggat gcagggctaa   5580

attgcaaaat aaaataaaat agccagcgta cacaatgaga tattctaaac ttccattctg   5640

ttttcttttc acattggctc catcactggt gactgatgaa gagcatcctc tttattcagt   5700

ataagccggc agcaagcagt tctacctaac gtcccacatc cttctcatgc caacacttct   5760

gtaattgatc attataaaga aaaaacaagg taacagtcat agttcacctg tctcttatct   5820

attcacttct ggtgccacaa ctgtttatcc ttttttgaag aaaataaggg aacagaaatg   5880

cctttttgta ttgcaatcga aatgaaagaa gagttgatgt taaaaaaaca aaagtcaagt   5940

gatttattat atacagtggg cgttcaagtc tagtcgagca agctcaggag aatgtaatta   6000

aataatttta tattttttaa tttattttgt atctcacctg tcatggatga attcattcac   6060

tgaatatgta atattgaact taaaaaaaaa aaaaaaaaaa cagtggacag aactagcctg   6120

aaattgccat gtgggatgtt ctgttctcac cgttcatgtc gtgtgttgtg ctgctgtgtg   6180

accgtcatca tttgcatggc tccaccacgt cctcctgaac acctccaaga cgtaactgcc   6240

aatttttcac accactcatc acatgaccat tttgtatatg aatatatggt tatatgtgga   6300

tattttcata cctagagttt tgccatctaa tctgagctca gcataaattt aattggagtt   6360

tttcaagggc tggtatcttt tctatggaaa tgttccaaag tactttttaa ggaagtttca   6420

aaactataaa taaccttaga tttgactggg agtttggtat caacccaaag ccatcagttg   6480

caagcatacc atgaatattt ttcttataga cagagctata aaaaaagata cagtagacca   6540

aaatagaaag caaataaacc atataaagag ttctatagta tatgccactt atacacatgt   6600

atatgcattt atgcagagac acatatttat atataaaata aatggacata aagagcttt    6659


<210>  2463
<211>  1556
<212>  PRT
<213>  Homo sapiens

<400>  2463


Met Tyr Val Arg Val Ser Phe Asp Thr Lys Pro Asp Leu Leu Leu His 
1               5                   10                  15      


Leu Met Thr Lys Glu Trp Gln Leu Glu Leu Pro Lys Leu Leu Ile Ser 
            20                  25                  30          


Val His Gly Gly Leu Gln Asn Phe Glu Leu Gln Pro Lys Leu Lys Gln 
        35                  40                  45              


Val Phe Gly Lys Gly Leu Ile Lys Ala Ala Met Thr Thr Gly Ala Trp 
    50                  55                  60                  


Ile Phe Thr Gly Gly Val Asn Thr Gly Val Ile Arg His Val Gly Asp 
65                  70                  75                  80  


Ala Leu Lys Asp His Ala Ser Lys Ser Arg Gly Lys Ile Cys Thr Ile 
                85                  90                  95      


Gly Ile Ala Pro Trp Gly Ile Val Glu Asn Gln Glu Asp Leu Ile Gly 
            100                 105                 110         


Arg Asp Val Val Arg Pro Tyr Gln Thr Met Ser Asn Pro Met Ser Lys 
        115                 120                 125             


Leu Thr Val Leu Asn Ser Met His Ser His Phe Ile Leu Ala Asp Asn 
    130                 135                 140                 


Gly Thr Thr Gly Lys Tyr Gly Ala Glu Val Lys Leu Arg Arg Gln Leu 
145                 150                 155                 160 


Glu Lys His Ile Ser Leu Gln Lys Ile Asn Thr Arg Ile Gly Gln Gly 
                165                 170                 175     


Val Pro Val Val Ala Leu Ile Val Glu Gly Gly Pro Asn Val Ile Ser 
            180                 185                 190         


Ile Val Leu Glu Tyr Leu Arg Asp Thr Pro Pro Val Pro Val Val Val 
        195                 200                 205             


Cys Asp Gly Ser Gly Arg Ala Ser Asp Ile Leu Ala Phe Gly His Lys 
    210                 215                 220                 


Tyr Ser Glu Glu Gly Gly Leu Ile Asn Glu Ser Leu Arg Asp Gln Leu 
225                 230                 235                 240 


Leu Val Thr Ile Gln Lys Thr Phe Thr Tyr Thr Arg Thr Gln Ala Gln 
                245                 250                 255     


His Leu Phe Ile Ile Leu Met Glu Cys Met Lys Lys Lys Glu Leu Ile 
            260                 265                 270         


Thr Val Phe Arg Met Gly Ser Glu Gly His Gln Asp Ile Asp Leu Ala 
        275                 280                 285             


Ile Leu Thr Ala Leu Leu Lys Gly Ala Asn Ala Ser Ala Pro Asp Gln 
    290                 295                 300                 


Leu Ser Leu Ala Leu Ala Trp Asn Arg Val Asp Ile Ala Arg Ser Gln 
305                 310                 315                 320 


Ile Phe Ile Tyr Gly Gln Gln Trp Pro Val Gly Ser Leu Glu Gln Ala 
                325                 330                 335     


Met Leu Asp Ala Leu Val Leu Asp Arg Val Asp Phe Val Lys Leu Leu 
            340                 345                 350         


Ile Glu Asn Gly Val Ser Met His Arg Phe Leu Thr Ile Ser Arg Leu 
        355                 360                 365             


Glu Glu Leu Tyr Asn Thr Arg His Gly Pro Ser Asn Thr Leu Tyr His 
    370                 375                 380                 


Leu Val Arg Asp Val Lys Lys Arg Glu Tyr Pro Gly Phe Gly Trp Ile 
385                 390                 395                 400 


Tyr Phe Lys Gly Asn Leu Pro Pro Asp Tyr Arg Ile Ser Leu Ile Asp 
                405                 410                 415     


Ile Gly Leu Val Ile Glu Tyr Leu Met Gly Gly Ala Tyr Arg Cys Asn 
            420                 425                 430         


Tyr Thr Arg Lys Arg Phe Arg Thr Leu Tyr His Asn Leu Phe Gly Pro 
        435                 440                 445             


Lys Arg Asp Asp Ile Pro Leu Arg Arg Gly Arg Lys Thr Thr Lys Lys 
    450                 455                 460                 


Arg Glu Glu Glu Val Asp Ile Asp Leu Asp Asp Pro Glu Ile Asn His 
465                 470                 475                 480 


Phe Pro Phe Pro Phe His Glu Leu Met Val Trp Ala Val Leu Met Lys 
                485                 490                 495     


Arg Gln Lys Met Ala Leu Phe Phe Trp Gln His Gly Glu Glu Ala Met 
            500                 505                 510         


Ala Lys Ala Leu Val Ala Cys Lys Leu Cys Lys Ala Met Ala His Glu 
        515                 520                 525             


Ala Ser Glu Asn Asp Met Val Asp Asp Ile Ser Gln Glu Leu Asn His 
    530                 535                 540                 


Asn Ser Arg Asp Phe Gly Gln Leu Ala Val Glu Leu Leu Asp Gln Ser 
545                 550                 555                 560 


Tyr Lys Gln Asp Glu Gln Leu Ala Met Lys Leu Leu Thr Tyr Glu Leu 
                565                 570                 575     


Lys Asn Trp Ser Asn Ala Thr Cys Leu Gln Leu Ala Val Ala Ala Lys 
            580                 585                 590         


His Arg Asp Phe Ile Ala His Thr Cys Ser Gln Met Leu Leu Thr Asp 
        595                 600                 605             


Met Trp Met Gly Arg Leu Arg Met Arg Lys Asn Ser Gly Leu Lys Val 
    610                 615                 620                 


Ile Leu Gly Ile Leu Leu Pro Pro Ser Ile Leu Ser Leu Glu Phe Lys 
625                 630                 635                 640 


Asn Lys Asp Asp Met Pro Tyr Met Ser Gln Ala Gln Glu Ile His Leu 
                645                 650                 655     


Gln Glu Lys Glu Ala Glu Glu Pro Glu Lys Pro Thr Lys Glu Lys Glu 
            660                 665                 670         


Glu Glu Asp Met Glu Leu Thr Ala Met Leu Gly Arg Asn Asn Gly Glu 
        675                 680                 685             


Ser Ser Arg Lys Lys Asp Glu Glu Glu Val Gln Ser Lys His Arg Leu 
    690                 695                 700                 


Ile Pro Leu Gly Arg Lys Ile Tyr Glu Phe Tyr Asn Ala Pro Ile Val 
705                 710                 715                 720 


Lys Phe Trp Phe Tyr Thr Leu Ala Tyr Ile Gly Tyr Leu Met Leu Phe 
                725                 730                 735     


Asn Tyr Ile Val Leu Val Lys Met Glu Arg Trp Pro Ser Thr Gln Glu 
            740                 745                 750         


Trp Ile Val Ile Ser Tyr Ile Phe Thr Leu Gly Ile Glu Lys Met Arg 
        755                 760                 765             


Glu Ile Leu Met Ser Glu Pro Gly Lys Leu Leu Gln Lys Val Lys Val 
    770                 775                 780                 


Trp Leu Gln Glu Tyr Trp Asn Val Thr Asp Leu Ile Ala Ile Leu Leu 
785                 790                 795                 800 


Phe Ser Val Gly Met Ile Leu Arg Leu Gln Asp Gln Pro Phe Arg Ser 
                805                 810                 815     


Asp Gly Arg Val Ile Tyr Cys Val Asn Ile Ile Tyr Trp Tyr Ile Arg 
            820                 825                 830         


Leu Leu Asp Ile Phe Gly Val Asn Lys Tyr Leu Gly Pro Tyr Val Met 
        835                 840                 845             


Met Ile Gly Lys Met Met Ile Asp Met Met Tyr Phe Val Ile Ile Met 
    850                 855                 860                 


Leu Val Val Leu Met Ser Phe Gly Val Ala Arg Gln Ala Ile Leu Phe 
865                 870                 875                 880 


Pro Asn Glu Glu Pro Ser Trp Lys Leu Ala Lys Asn Ile Phe Tyr Met 
                885                 890                 895     


Pro Tyr Trp Met Ile Tyr Gly Glu Val Phe Ala Asp Gln Ile Asp Pro 
            900                 905                 910         


Pro Cys Gly Gln Asn Glu Thr Arg Glu Asp Gly Lys Ile Ile Gln Leu 
        915                 920                 925             


Pro Pro Cys Lys Thr Gly Ala Trp Ile Val Pro Ala Ile Met Ala Cys 
    930                 935                 940                 


Tyr Leu Leu Val Ala Asn Ile Leu Leu Val Asn Leu Leu Ile Ala Val 
945                 950                 955                 960 


Phe Asn Asn Thr Phe Phe Glu Val Lys Ser Ile Ser Asn Gln Val Trp 
                965                 970                 975     


Lys Phe Gln Arg Tyr Gln Leu Ile Met Thr Phe His Glu Arg Pro Val 
            980                 985                 990         


Leu Pro Pro Pro Leu Ile Ile Phe  Ser His Met Thr Met  Ile Phe Gln 
        995                 1000                 1005             


His Leu  Cys Cys Arg Trp Arg  Lys His Glu Ser Asp  Pro Asp Glu 
    1010                 1015                 1020             


Arg Asp  Tyr Gly Leu Lys Leu  Phe Ile Thr Asp Asp  Glu Leu Lys 
    1025                 1030                 1035             


Lys Val  His Asp Phe Glu Glu  Gln Cys Ile Glu Glu  Tyr Phe Arg 
    1040                 1045                 1050             


Glu Lys  Asp Asp Arg Phe Asn  Ser Ser Asn Asp Glu  Arg Ile Arg 
    1055                 1060                 1065             


Val Thr  Ser Glu Arg Val Glu  Asn Met Ser Met Arg  Leu Glu Glu 
    1070                 1075                 1080             


Val Asn  Glu Arg Glu His Ser  Met Lys Ala Ser Leu  Gln Thr Val 
    1085                 1090                 1095             


Asp Ile  Arg Leu Ala Gln Leu  Glu Asp Leu Ile Gly  Arg Met Ala 
    1100                 1105                 1110             


Thr Ala  Leu Glu Arg Leu Thr  Gly Leu Glu Arg Ala  Glu Ser Asn 
    1115                 1120                 1125             


Lys Ile  Arg Ser Arg Thr Ser  Ser Asp Cys Thr Asp  Ala Ala Tyr 
    1130                 1135                 1140             


Ile Val  Arg Gln Ser Ser Phe  Asn Ser Gln Glu Gly  Asn Thr Phe 
    1145                 1150                 1155             


Lys Leu  Gln Glu Ser Ile Asp  Pro Ala Gly Glu Glu  Thr Met Ser 
    1160                 1165                 1170             


Pro Thr  Ser Pro Thr Leu Met  Pro Arg Met Arg Ser  His Ser Phe 
    1175                 1180                 1185             


Tyr Ser  Val Asn Met Lys Asp  Lys Gly Gly Ile Glu  Lys Leu Glu 
    1190                 1195                 1200             


Ser Ile  Phe Lys Glu Arg Ser  Leu Ser Leu His Arg  Ala Thr Ser 
    1205                 1210                 1215             


Ser His  Ser Val Ala Lys Glu  Pro Lys Ala Pro Ala  Ala Pro Ala 
    1220                 1225                 1230             


Asn Thr  Leu Ala Ile Val Pro  Asp Ser Arg Arg Pro  Ser Ser Cys 
    1235                 1240                 1245             


Ile Asp  Ile Tyr Val Ser Ala  Met Asp Glu Leu His  Cys Asp Ile 
    1250                 1255                 1260             


Asp Pro  Leu Asp Asn Ser Val  Asn Ile Leu Gly Leu  Gly Glu Pro 
    1265                 1270                 1275             


Ser Phe  Ser Thr Pro Val Pro  Ser Thr Ala Pro Ser  Ser Ser Ala 
    1280                 1285                 1290             


Tyr Ala  Thr Leu Ala Pro Thr  Asp Arg Pro Pro Ser  Arg Ser Ile 
    1295                 1300                 1305             


Asp Phe  Glu Asp Ile Thr Ser  Met Asp Thr Arg Ser  Phe Ser Ser 
    1310                 1315                 1320             


Asp Tyr  Thr His Leu Pro Glu  Cys Gln Asn Pro Trp  Asp Ser Glu 
    1325                 1330                 1335             


Pro Pro  Met Tyr His Thr Ile  Glu Arg Ser Lys Ser  Ser Arg Tyr 
    1340                 1345                 1350             


Leu Ala  Thr Thr Pro Phe Leu  Leu Glu Glu Ala Pro  Ile Val Lys 
    1355                 1360                 1365             


Ser His  Ser Phe Met Phe Ser  Pro Ser Arg Ser Tyr  Tyr Ala Asn 
    1370                 1375                 1380             


Phe Gly  Val Pro Val Lys Thr  Ala Glu Tyr Thr Ser  Ile Thr Asp 
    1385                 1390                 1395             


Cys Ile  Asp Thr Arg Cys Val  Asn Ala Pro Gln Ala  Ile Ala Asp 
    1400                 1405                 1410             


Arg Ala  Ala Phe Pro Gly Gly  Leu Gly Asp Lys Val  Glu Asp Leu 
    1415                 1420                 1425             


Thr Cys  Cys His Pro Glu Arg  Glu Ala Glu Leu Ser  His Pro Ser 
    1430                 1435                 1440             


Ser Asp  Ser Glu Glu Asn Glu  Ala Lys Gly Arg Arg  Ala Thr Ile 
    1445                 1450                 1455             


Ala Ile  Ser Ser Gln Glu Gly  Asp Asn Ser Glu Arg  Thr Leu Ser 
    1460                 1465                 1470             


Asn Asn  Ile Thr Val Pro Lys  Ile Glu Arg Ala Asn  Ser Tyr Ser 
    1475                 1480                 1485             


Ala Glu  Glu Pro Ser Ala Pro  Tyr Ala His Thr Arg  Lys Ser Phe 
    1490                 1495                 1500             


Ser Ile  Ser Asp Lys Leu Asp  Arg Gln Arg Asn Thr  Ala Ser Leu 
    1505                 1510                 1515             


Arg Asn  Pro Phe Gln Arg Ser  Lys Ser Ser Lys Pro  Glu Gly Arg 
    1520                 1525                 1530             


Gly Asp  Ser Leu Ser Met Arg  Arg Leu Ser Arg Thr  Ser Ala Phe 
    1535                 1540                 1545             


Gln Ser  Phe Glu Ser Lys His  Asn 
    1550                 1555     

<210>  2464
<211>  6698
<212>  DNA
<213>  Homo sapiens

<400>  2464
tagtgaggct aatcccgaag cagcacattc caaggggcta atctgcccaa gttcattgct     60

tacttgaaac gtctcttggg ggaagagccg aacaagtgac tttttttttc cagtgggcgg    120

tcataagagc attattaacg gaatgaccag ccctagctgc agcaaaatga aagcaacagg    180

agctgctccg gggactgctt ttgccagtac ccagaatcag tgctcaggct cagaaatcct    240

ggatagaaag agcattttat aaaagagaat gtgtccacat catacccagc accaaagacc    300

cccataggtg ttgctgtggg cgtctgatag gccagcatgt tggcctcacc cccagtatct    360

ccgtgcttca gaatgagaaa aatgaaagtc gcctctcccg aaatgacatc cagtctgaaa    420

agtggtccat cagcaaacac actcaactca gccctacgga tgcttttggg accattgagt    480

tccaaggagg tggccattcc aacaaagcca tgtatgtgcg agtatctttt gatacaaaac    540

ctgatctcct cttacacctg atgaccaagg aatggcagtt ggagcttccc aagcttctca    600

tctctgtcca tgggggcctg cagaactttg aactccagcc aaaactcaag caagtctttg    660

ggaaagggct catcaaagca gcaatgacaa ctggagcgtg gatattcact ggaggggtta    720

acacaggtgt tattcgtcat gttggcgatg ccttgaagga tcatgcctct aagtctcgag    780

gaaagatatg caccataggt attgccccct ggggaattgt ggaaaaccag gaggacctca    840

ttggaagaga tgttgtccgg ccataccaga ccatgtccaa tcccatgagc aagctcactg    900

ttctcaacag catgcattcc cacttcattc tggctgacaa cgggaccact ggaaaatatg    960

gagcagaggt gaaacttcga agacaactgg aaaagcatat ttcactccag aagataaaca   1020

caagatgcct gccgtttttc tctcttgact cccgcttgtt ttattcattt tggggtagtt   1080

gccagttaga ctcagttgga atcggtcaag gtgttcctgt ggtggcactc atagtggaag   1140

gaggacccaa tgtgatctcg attgttttgg agtaccttcg agacacccct cccgtgccag   1200

tggttgtctg tgatgggagt ggacgggcat cggacatcct ggcctttggg cataaatact   1260

cagaagaagg cggactgata aatgaatctt tgagggacca gctgttggtg actatacaga   1320

agactttcac atacactcga acccaagctc agcatctgtt catcatcctc atggagtgca   1380

tgaagaagaa ggaattgatt acggtatttc ggatgggatc agaaggacac caggacattg   1440

atttggctat cctgacagct ttactcaaag gagccaatgc ctcggcccca gaccaactga   1500

gcttagcttt agcctggaac agagtcgaca tcgctcgcag ccagatcttt atttacgggc   1560

aacagtggcc ggtgggatct ctggagcaag ccatgttgga tgccttagtt ctggacagag   1620

tggattttgt gaaattactc atagagaatg gagtaagcat gcaccgtttt ctcaccatct   1680

ccagactaga ggaattgtac aatacgagac atgggccctc aaatacattg taccacttgg   1740

tcagggatgt caaaaagggg aacctgcccc cagactacag aatcagcctg attgacatcg   1800

gcctggtgat cgagtacctg atgggcgggg cttatcgctg caactacacg cgcaagcgct   1860

tccggaccct ctaccacaac ctcttcggcc ccaagaggga tgatattccc ttgaggcgag   1920

gaagaaagac aaccaagaaa cgtgaagaag aggtggacat tgacttggat gatcctgaga   1980

tcaaccactt ccccttccct ttccatgagc tcatggtgtg ggctgttctc atgaagcggc   2040

agaagatggc cctgttcttc tggcagcacg gtgaggaggc catggccaag gccctggtgg   2100

cctgcaagct ctgcaaagcc atggctcatg aggcctctga gaacgacatg gttgacgaca   2160

tttcccagga gctgaatcac aattccagag actttggcca gctggctgtg gagctcctgg   2220

accagtccta caagcaggac gaacagctgg ccatgaaact gctgacgtat gagctgaaga   2280

actggagcaa cgccacgtgc ctgcagcttg ccgtggctgc caaacaccgc gacttcatcg   2340

cgcacacgtg cagccagatg ctgctcaccg acatgtggat gggccggctc cgcatgcgca   2400

agaactcagg cctcaaggta attctgggaa ttctacttcc tccttcaatt ctcagcttgg   2460

agttcaagaa caaagacgac atgccctata tgtctcaggc ccaggaaatc cacctccaag   2520

agaaggaggc agaagaacca gagaagccca caaaggaaaa agaggaagag gacatggagc   2580

tcacagcaat gttgggacga aacaacgggg agtcctccag gaagaaggat gaagaggaag   2640

ttcagagcaa gcaccggtta atccccctcg gcagaaaaat ctatgaattc tacaatgcac   2700

ccatcgtgaa gttctggttc tacacactgg cgtatatcgg atacctgatg ctcttcaact   2760

atatcgtgtt agtgaagatg gaacgctggc cgtccaccca ggaatggatc gtaatctcct   2820

atattttcac cctgggaata gaaaagatga gagagattct gatgtcagag ccagggaagt   2880

tgctacagaa agtgaaggta tggctgcagg agtactggaa tgtcacggac ctcatcgcca   2940

tccttctgtt ttctgtcgga atgatccttc gtctccaaga ccagcccttc aggagtgacg   3000

ggagggtcat ctactgcgtg aacatcattt actggtatat ccgtctccta gacatcttcg   3060

gcgtgaacaa gtatttgggc ccgtatgtaa tgatgattgg aaaaatgatg atagacatga   3120

tgtactttgt catcattatg ctggtggttc tgatgagctt tggggtcgcc aggcaagcca   3180

tcctttttcc caatgaggag ccatcatgga aactggccaa gaacatcttc tacatgccct   3240

attggatgat ttatggggaa gtgtttgcgg accagataga ccctccctgt ggacagaatg   3300

agacccgaga ggatggtaaa ataatccagc tgcctccctg caagacagga gcttggatcg   3360

tgccggccat catggcctgc tacctcttag tggcaaacat cttgctggtc aacctcctca   3420

ttgctgtctt taacaataca ttttttgaag taaaatcgat atccaaccaa gtctggaagt   3480

ttcagaggta tcagctcatc atgactttcc atgaaaggcc agttctgccc ccaccactga   3540

tcatcttcag ccacatgacc atgatattcc agcacctgtg ctgccgatgg aggaaacacg   3600

agagcgaccc ggatgaaagg gactacggcc tgaaactctt cataaccgat gatgagctca   3660

agaaagtaca tgactttgaa gagcaatgca tagaagaata cttcagagaa aaggatgatc   3720

ggttcaactc atctaatgat gagaggatac gggtgacttc agaaagggtg gagaacatgt   3780

ctatgcggct ggaggaagtc aacgagagag agcactccat gaaggcttca ctccagaccg   3840

tggacatccg gctggcgcag ctggaagacc ttatcgggcg catggccacg gccctggagc   3900

gcctgacagg tctggagcgg gccgagtcca acaaaatccg ctcgaggacc tcgtcagact   3960

gcacggacgc cgcctacatt gtccgtcaga gcagcttcaa cagccaggaa gggaacacct   4020

tcaagctcca agagagtata gaccctgcag gtgaggagac catgtcccca acttctccaa   4080

ccttaatgcc ccgtatgcga agccattctt tctattcggt caatatgaaa gacaaaggtg   4140

gtatagaaaa gttggaaagt atttttaaag aaaggtccct gagcctacac cgggctacta   4200

gttcccactc tgtagcaaaa gaacccaaag ctcctgcagc ccctgccaac accttggcca   4260

ttgttcctga ttccagaaga ccatcatcgt gtatagacat ctatgtctct gctatggatg   4320

agctccactg tgatatagac cctctggaca attccgtgaa catccttggg ctgggcgagc   4380

caagcttttc aactccagta ccttccacag ccccttcaag tagtgcctat gcaacacttg   4440

cacccacaga cagacctcca agccggagca ttgattttga ggacatcacc tccatggaca   4500

ctagatcttt ttcttcagac tacacccacc tcccagaatg ccaaaacccc tgggactcag   4560

agcctccgat gtaccacacc attgagcgtt ccaaaagtag ccgctaccta gccaccacac   4620

cctttcttct agaagaggct cccattgtga aatctcatag ctttatgttt tccccctcaa   4680

ggagctatta tgccaacttt ggggtgcctg taaaaacagc agaatacaca agtattacag   4740

actgtattga cacaaggtgt gtcaatgccc ctcaagcaat tgcggacaga gctgccttcc   4800

ctggaggtct tggagacaaa gtggaggact taacttgctg ccatccagag cgagaagcag   4860

aactgagtca ccccagctct gacagtgagg agaatgaggc caaaggccgc agagccacca   4920

ttgcaatatc ctcccaggag ggtgataact cagagagaac cctgtccaac aacatcactg   4980

ttcccaagat agagcgcgcc aacagctact cggcagagga gccaagtgcg ccatatgcac   5040

acaccaggaa gagcttctcc atcagtgaca aactcgacag gcagcggaac acagcaagcc   5100

tgcgaaatcc cttccagaga agcaagtcct ccaagccgga gggccgaggg gacagcctgt   5160

ccatgaggag actgtccaga acatcggctt tccaaagctt tgaaagcaag cacaactaaa   5220

ccttcttaat atccgccaca gaaggctcaa gaatccagcc ctaaaattct ctccaactcc   5280

agtttttccc ctttccttga atcatacctg ctttattctt agctgagcaa aacaagcaat   5340

gctttgggag gtgttaactc aaaggtgact tctgggccac agatcaagaa agcatttgat   5400

ctgacccagt gccagacaca ggggatttaa ggcatgttca cacttgctgg gcagggaggg   5460

ggaagagagg gagaaggaag ggttagagat gaatgtgtat ccgcagtcac agcagaaagc   5520

catgagagca ggggaaacaa ggggcttcga gcacgctcca tgccaggagg catctgttga   5580

tttctgacca ttatcaagag ttgtaggatg cagggctaaa ttgcaaaata aaataaaata   5640

gccagcgtac acaatgagat attctaaact tccattctgt tttcttttca cattggctcc   5700

atcactggtg actgatgaag agcatcctct ttattcagta taagccggca gcaagcagtt   5760

ctacctaacg tcccacatcc ttctcatgcc aacacttctg taattgatca ttataaagaa   5820

aaaacaaggt aacagtcata gttcacctgt ctcttatcta ttcacttctg gtgccacaac   5880

tgtttatcct tttttgaaga aaataaggga acagaaatgc ctttttgtat tgcaatcgaa   5940

atgaaagaag agttgatgtt aaaaaaacaa aagtcaagtg atttattata tacagtgggc   6000

gttcaagtct agtcgagcaa gctcaggaga atgtaattaa ataattttat attttttaat   6060

ttattttgta tctcacctgt catggatgaa ttcattcact gaatatgtaa tattgaactt   6120

aaaaaaaaaa aaaaaaaaac agtggacaga actagcctga aattgccatg tgggatgttc   6180

tgttctcacc gttcatgtcg tgtgttgtgc tgctgtgtga ccgtcatcat ttgcatggct   6240

ccaccacgtc ctcctgaaca cctccaagac gtaactgcca atttttcaca ccactcatca   6300

catgaccatt ttgtatatga atatatggtt atatgtggat attttcatac ctagagtttt   6360

gccatctaat ctgagctcag cataaattta attggagttt ttcaagggct ggtatctttt   6420

ctatggaaat gttccaaagt actttttaag gaagtttcaa aactataaat aaccttagat   6480

ttgactggga gtttggtatc aacccaaagc catcagttgc aagcatacca tgaatatttt   6540

tcttatagac agagctataa aaaaagatac agtagaccaa aatagaaagc aaataaacca   6600

tataaagagt tctatagtat atgccactta tacacatgta tatgcattta tgcagagaca   6660

catatttata tataaaataa atggacataa agagcttt                           6698


<210>  2465
<211>  1569
<212>  PRT
<213>  Homo sapiens

<400>  2465


Met Tyr Val Arg Val Ser Phe Asp Thr Lys Pro Asp Leu Leu Leu His 
1               5                   10                  15      


Leu Met Thr Lys Glu Trp Gln Leu Glu Leu Pro Lys Leu Leu Ile Ser 
            20                  25                  30          


Val His Gly Gly Leu Gln Asn Phe Glu Leu Gln Pro Lys Leu Lys Gln 
        35                  40                  45              


Val Phe Gly Lys Gly Leu Ile Lys Ala Ala Met Thr Thr Gly Ala Trp 
    50                  55                  60                  


Ile Phe Thr Gly Gly Val Asn Thr Gly Val Ile Arg His Val Gly Asp 
65                  70                  75                  80  


Ala Leu Lys Asp His Ala Ser Lys Ser Arg Gly Lys Ile Cys Thr Ile 
                85                  90                  95      


Gly Ile Ala Pro Trp Gly Ile Val Glu Asn Gln Glu Asp Leu Ile Gly 
            100                 105                 110         


Arg Asp Val Val Arg Pro Tyr Gln Thr Met Ser Asn Pro Met Ser Lys 
        115                 120                 125             


Leu Thr Val Leu Asn Ser Met His Ser His Phe Ile Leu Ala Asp Asn 
    130                 135                 140                 


Gly Thr Thr Gly Lys Tyr Gly Ala Glu Val Lys Leu Arg Arg Gln Leu 
145                 150                 155                 160 


Glu Lys His Ile Ser Leu Gln Lys Ile Asn Thr Arg Cys Leu Pro Phe 
                165                 170                 175     


Phe Ser Leu Asp Ser Arg Leu Phe Tyr Ser Phe Trp Gly Ser Cys Gln 
            180                 185                 190         


Leu Asp Ser Val Gly Ile Gly Gln Gly Val Pro Val Val Ala Leu Ile 
        195                 200                 205             


Val Glu Gly Gly Pro Asn Val Ile Ser Ile Val Leu Glu Tyr Leu Arg 
    210                 215                 220                 


Asp Thr Pro Pro Val Pro Val Val Val Cys Asp Gly Ser Gly Arg Ala 
225                 230                 235                 240 


Ser Asp Ile Leu Ala Phe Gly His Lys Tyr Ser Glu Glu Gly Gly Leu 
                245                 250                 255     


Ile Asn Glu Ser Leu Arg Asp Gln Leu Leu Val Thr Ile Gln Lys Thr 
            260                 265                 270         


Phe Thr Tyr Thr Arg Thr Gln Ala Gln His Leu Phe Ile Ile Leu Met 
        275                 280                 285             


Glu Cys Met Lys Lys Lys Glu Leu Ile Thr Val Phe Arg Met Gly Ser 
    290                 295                 300                 


Glu Gly His Gln Asp Ile Asp Leu Ala Ile Leu Thr Ala Leu Leu Lys 
305                 310                 315                 320 


Gly Ala Asn Ala Ser Ala Pro Asp Gln Leu Ser Leu Ala Leu Ala Trp 
                325                 330                 335     


Asn Arg Val Asp Ile Ala Arg Ser Gln Ile Phe Ile Tyr Gly Gln Gln 
            340                 345                 350         


Trp Pro Val Gly Ser Leu Glu Gln Ala Met Leu Asp Ala Leu Val Leu 
        355                 360                 365             


Asp Arg Val Asp Phe Val Lys Leu Leu Ile Glu Asn Gly Val Ser Met 
    370                 375                 380                 


His Arg Phe Leu Thr Ile Ser Arg Leu Glu Glu Leu Tyr Asn Thr Arg 
385                 390                 395                 400 


His Gly Pro Ser Asn Thr Leu Tyr His Leu Val Arg Asp Val Lys Lys 
                405                 410                 415     


Gly Asn Leu Pro Pro Asp Tyr Arg Ile Ser Leu Ile Asp Ile Gly Leu 
            420                 425                 430         


Val Ile Glu Tyr Leu Met Gly Gly Ala Tyr Arg Cys Asn Tyr Thr Arg 
        435                 440                 445             


Lys Arg Phe Arg Thr Leu Tyr His Asn Leu Phe Gly Pro Lys Arg Asp 
    450                 455                 460                 


Asp Ile Pro Leu Arg Arg Gly Arg Lys Thr Thr Lys Lys Arg Glu Glu 
465                 470                 475                 480 


Glu Val Asp Ile Asp Leu Asp Asp Pro Glu Ile Asn His Phe Pro Phe 
                485                 490                 495     


Pro Phe His Glu Leu Met Val Trp Ala Val Leu Met Lys Arg Gln Lys 
            500                 505                 510         


Met Ala Leu Phe Phe Trp Gln His Gly Glu Glu Ala Met Ala Lys Ala 
        515                 520                 525             


Leu Val Ala Cys Lys Leu Cys Lys Ala Met Ala His Glu Ala Ser Glu 
    530                 535                 540                 


Asn Asp Met Val Asp Asp Ile Ser Gln Glu Leu Asn His Asn Ser Arg 
545                 550                 555                 560 


Asp Phe Gly Gln Leu Ala Val Glu Leu Leu Asp Gln Ser Tyr Lys Gln 
                565                 570                 575     


Asp Glu Gln Leu Ala Met Lys Leu Leu Thr Tyr Glu Leu Lys Asn Trp 
            580                 585                 590         


Ser Asn Ala Thr Cys Leu Gln Leu Ala Val Ala Ala Lys His Arg Asp 
        595                 600                 605             


Phe Ile Ala His Thr Cys Ser Gln Met Leu Leu Thr Asp Met Trp Met 
    610                 615                 620                 


Gly Arg Leu Arg Met Arg Lys Asn Ser Gly Leu Lys Val Ile Leu Gly 
625                 630                 635                 640 


Ile Leu Leu Pro Pro Ser Ile Leu Ser Leu Glu Phe Lys Asn Lys Asp 
                645                 650                 655     


Asp Met Pro Tyr Met Ser Gln Ala Gln Glu Ile His Leu Gln Glu Lys 
            660                 665                 670         


Glu Ala Glu Glu Pro Glu Lys Pro Thr Lys Glu Lys Glu Glu Glu Asp 
        675                 680                 685             


Met Glu Leu Thr Ala Met Leu Gly Arg Asn Asn Gly Glu Ser Ser Arg 
    690                 695                 700                 


Lys Lys Asp Glu Glu Glu Val Gln Ser Lys His Arg Leu Ile Pro Leu 
705                 710                 715                 720 


Gly Arg Lys Ile Tyr Glu Phe Tyr Asn Ala Pro Ile Val Lys Phe Trp 
                725                 730                 735     


Phe Tyr Thr Leu Ala Tyr Ile Gly Tyr Leu Met Leu Phe Asn Tyr Ile 
            740                 745                 750         


Val Leu Val Lys Met Glu Arg Trp Pro Ser Thr Gln Glu Trp Ile Val 
        755                 760                 765             


Ile Ser Tyr Ile Phe Thr Leu Gly Ile Glu Lys Met Arg Glu Ile Leu 
    770                 775                 780                 


Met Ser Glu Pro Gly Lys Leu Leu Gln Lys Val Lys Val Trp Leu Gln 
785                 790                 795                 800 


Glu Tyr Trp Asn Val Thr Asp Leu Ile Ala Ile Leu Leu Phe Ser Val 
                805                 810                 815     


Gly Met Ile Leu Arg Leu Gln Asp Gln Pro Phe Arg Ser Asp Gly Arg 
            820                 825                 830         


Val Ile Tyr Cys Val Asn Ile Ile Tyr Trp Tyr Ile Arg Leu Leu Asp 
        835                 840                 845             


Ile Phe Gly Val Asn Lys Tyr Leu Gly Pro Tyr Val Met Met Ile Gly 
    850                 855                 860                 


Lys Met Met Ile Asp Met Met Tyr Phe Val Ile Ile Met Leu Val Val 
865                 870                 875                 880 


Leu Met Ser Phe Gly Val Ala Arg Gln Ala Ile Leu Phe Pro Asn Glu 
                885                 890                 895     


Glu Pro Ser Trp Lys Leu Ala Lys Asn Ile Phe Tyr Met Pro Tyr Trp 
            900                 905                 910         


Met Ile Tyr Gly Glu Val Phe Ala Asp Gln Ile Asp Pro Pro Cys Gly 
        915                 920                 925             


Gln Asn Glu Thr Arg Glu Asp Gly Lys Ile Ile Gln Leu Pro Pro Cys 
    930                 935                 940                 


Lys Thr Gly Ala Trp Ile Val Pro Ala Ile Met Ala Cys Tyr Leu Leu 
945                 950                 955                 960 


Val Ala Asn Ile Leu Leu Val Asn Leu Leu Ile Ala Val Phe Asn Asn 
                965                 970                 975     


Thr Phe Phe Glu Val Lys Ser Ile Ser Asn Gln Val Trp Lys Phe Gln 
            980                 985                 990         


Arg Tyr Gln Leu Ile Met Thr Phe  His Glu Arg Pro Val  Leu Pro Pro 
        995                 1000                 1005             


Pro Leu  Ile Ile Phe Ser His  Met Thr Met Ile Phe  Gln His Leu 
    1010                 1015                 1020             


Cys Cys  Arg Trp Arg Lys His  Glu Ser Asp Pro Asp  Glu Arg Asp 
    1025                 1030                 1035             


Tyr Gly  Leu Lys Leu Phe Ile  Thr Asp Asp Glu Leu  Lys Lys Val 
    1040                 1045                 1050             


His Asp  Phe Glu Glu Gln Cys  Ile Glu Glu Tyr Phe  Arg Glu Lys 
    1055                 1060                 1065             


Asp Asp  Arg Phe Asn Ser Ser  Asn Asp Glu Arg Ile  Arg Val Thr 
    1070                 1075                 1080             


Ser Glu  Arg Val Glu Asn Met  Ser Met Arg Leu Glu  Glu Val Asn 
    1085                 1090                 1095             


Glu Arg  Glu His Ser Met Lys  Ala Ser Leu Gln Thr  Val Asp Ile 
    1100                 1105                 1110             


Arg Leu  Ala Gln Leu Glu Asp  Leu Ile Gly Arg Met  Ala Thr Ala 
    1115                 1120                 1125             


Leu Glu  Arg Leu Thr Gly Leu  Glu Arg Ala Glu Ser  Asn Lys Ile 
    1130                 1135                 1140             


Arg Ser  Arg Thr Ser Ser Asp  Cys Thr Asp Ala Ala  Tyr Ile Val 
    1145                 1150                 1155             


Arg Gln  Ser Ser Phe Asn Ser  Gln Glu Gly Asn Thr  Phe Lys Leu 
    1160                 1165                 1170             


Gln Glu  Ser Ile Asp Pro Ala  Gly Glu Glu Thr Met  Ser Pro Thr 
    1175                 1180                 1185             


Ser Pro  Thr Leu Met Pro Arg  Met Arg Ser His Ser  Phe Tyr Ser 
    1190                 1195                 1200             


Val Asn  Met Lys Asp Lys Gly  Gly Ile Glu Lys Leu  Glu Ser Ile 
    1205                 1210                 1215             


Phe Lys  Glu Arg Ser Leu Ser  Leu His Arg Ala Thr  Ser Ser His 
    1220                 1225                 1230             


Ser Val  Ala Lys Glu Pro Lys  Ala Pro Ala Ala Pro  Ala Asn Thr 
    1235                 1240                 1245             


Leu Ala  Ile Val Pro Asp Ser  Arg Arg Pro Ser Ser  Cys Ile Asp 
    1250                 1255                 1260             


Ile Tyr  Val Ser Ala Met Asp  Glu Leu His Cys Asp  Ile Asp Pro 
    1265                 1270                 1275             


Leu Asp  Asn Ser Val Asn Ile  Leu Gly Leu Gly Glu  Pro Ser Phe 
    1280                 1285                 1290             


Ser Thr  Pro Val Pro Ser Thr  Ala Pro Ser Ser Ser  Ala Tyr Ala 
    1295                 1300                 1305             


Thr Leu  Ala Pro Thr Asp Arg  Pro Pro Ser Arg Ser  Ile Asp Phe 
    1310                 1315                 1320             


Glu Asp  Ile Thr Ser Met Asp  Thr Arg Ser Phe Ser  Ser Asp Tyr 
    1325                 1330                 1335             


Thr His  Leu Pro Glu Cys Gln  Asn Pro Trp Asp Ser  Glu Pro Pro 
    1340                 1345                 1350             


Met Tyr  His Thr Ile Glu Arg  Ser Lys Ser Ser Arg  Tyr Leu Ala 
    1355                 1360                 1365             


Thr Thr  Pro Phe Leu Leu Glu  Glu Ala Pro Ile Val  Lys Ser His 
    1370                 1375                 1380             


Ser Phe  Met Phe Ser Pro Ser  Arg Ser Tyr Tyr Ala  Asn Phe Gly 
    1385                 1390                 1395             


Val Pro  Val Lys Thr Ala Glu  Tyr Thr Ser Ile Thr  Asp Cys Ile 
    1400                 1405                 1410             


Asp Thr  Arg Cys Val Asn Ala  Pro Gln Ala Ile Ala  Asp Arg Ala 
    1415                 1420                 1425             


Ala Phe  Pro Gly Gly Leu Gly  Asp Lys Val Glu Asp  Leu Thr Cys 
    1430                 1435                 1440             


Cys His  Pro Glu Arg Glu Ala  Glu Leu Ser His Pro  Ser Ser Asp 
    1445                 1450                 1455             


Ser Glu  Glu Asn Glu Ala Lys  Gly Arg Arg Ala Thr  Ile Ala Ile 
    1460                 1465                 1470             


Ser Ser  Gln Glu Gly Asp Asn  Ser Glu Arg Thr Leu  Ser Asn Asn 
    1475                 1480                 1485             


Ile Thr  Val Pro Lys Ile Glu  Arg Ala Asn Ser Tyr  Ser Ala Glu 
    1490                 1495                 1500             


Glu Pro  Ser Ala Pro Tyr Ala  His Thr Arg Lys Ser  Phe Ser Ile 
    1505                 1510                 1515             


Ser Asp  Lys Leu Asp Arg Gln  Arg Asn Thr Ala Ser  Leu Arg Asn 
    1520                 1525                 1530             


Pro Phe  Gln Arg Ser Lys Ser  Ser Lys Pro Glu Gly  Arg Gly Asp 
    1535                 1540                 1545             


Ser Leu  Ser Met Arg Arg Leu  Ser Arg Thr Ser Ala  Phe Gln Ser 
    1550                 1555                 1560             


Phe Glu  Ser Lys His Asn 
    1565                 

<210>  2466
<211>  6689
<212>  DNA
<213>  Homo sapiens

<400>  2466
tagtgaggct aatcccgaag cagcacattc caaggggcta atctgcccaa gttcattgct     60

tacttgaaac gtctcttggg ggaagagccg aacaagtgac tttttttttc cagtgggcgg    120

tcataagagc attattaacg gaatgaccag ccctagctgc agcaaaatga aagcaacagg    180

agctgctccg gggactgctt ttgccagtac ccagaatcag tgctcaggct cagaaatcct    240

ggatagaaag agcattttat aaaagagaat gtgtccacat catacccagc accaaagacc    300

cccataggtg ttgctgtggg cgtctgatag gccagcatgt tggcctcacc cccagtatct    360

ccgtgcttca gaatgagaaa aatgaaagtc gcctctcccg aaatgacatc cagtctgaaa    420

agtggtccat cagcaaacac actcaactca gccctacgga tgcttttggg accattgagt    480

tccaaggagg tggccattcc aacaaagcca tgtatgtgcg agtatctttt gatacaaaac    540

ctgatctcct cttacacctg atgaccaagg aatggcagtt ggagcttccc aagcttctca    600

tctctgtcca tgggggcctg cagaactttg aactccagcc aaaactcaag caagtctttg    660

ggaaagggct catcaaagca gcaatgacaa ctggagcgtg gatattcact ggaggggtta    720

acacaggtgt tattcgtcat gttggcgatg ccttgaagga tcatgcctct aagtctcgag    780

gaaagatatg caccataggt attgccccct ggggaattgt ggaaaaccag gaggacctca    840

ttggaagaga tgttgtccgg ccataccaga ccatgtccaa tcccatgagc aagctcactg    900

ttctcaacag catgcattcc cacttcattc tggctgacaa cgggaccact ggaaaatatg    960

gagcagaggt gaaacttcga agacaactgg aaaagcatat ttcactccag aagataaaca   1020

caagaatcgg tcaaggtgtt cctgtggtgg cactcatagt ggaaggagga cccaatgtga   1080

tctcgattgt tttggagtac cttcgagaca cccctcccgt gccagtggtt gtctgtgatg   1140

ggagtggacg ggcatcggac atcctggcct ttgggcataa atactcagaa gaaggcggac   1200

tgataaatga atctttgagg gaccagctgt tggtgactat acagaagact ttcacataca   1260

ctcgaaccca agctcagcat ctgttcatca tcctcatgga gtgcatgaag aagaaggaat   1320

tgattacggt atttcggatg ggatcagaag gacaccagga cattgatttg gctatcctga   1380

cagctttact caaaggagcc aatgcctcgg ccccagacca actgagctta gctttagcct   1440

ggaacagagt cgacatcgct cgcagccaga tctttattta cgggcaacag tggccggtgg   1500

gatctctgga gcaagccatg ttggatgcct tagttctgga cagagtggat tttgtgaaat   1560

tactcataga gaatggagta agcatgcacc gttttctcac catctccaga ctagaggaat   1620

tgtacaatac gagacatggg ccctcaaata cattgtacca cttggtcagg gatgtcaaaa   1680

agcgagagta tccaggtttc ggttggatct attttaaggg gaacctgccc ccagactaca   1740

gaatcagcct gattgacatc ggcctggtga tcgagtacct gatgggcggg gcttatcgct   1800

gcaactacac gcgcaagcgc ttccggaccc tctaccacaa cctcttcggc cccaagaggc   1860

ccaaagcctt gaaactgctg ggaatggagg atgatattcc cttgaggcga ggaagaaaga   1920

caaccaagaa acgtgaagaa gaggtggaca ttgacttgga tgatcctgag atcaaccact   1980

tccccttccc tttccatgag ctcatggtgt gggctgttct catgaagcgg cagaagatgg   2040

ccctgttctt ctggcagcac ggtgaggagg ccatggccaa ggccctggtg gcctgcaagc   2100

tctgcaaagc catggctcat gaggcctctg agaacgacat ggttgacgac atttcccagg   2160

agctgaatca caattccaga gactttggcc agctggctgt ggagctcctg gaccagtcct   2220

acaagcagga cgaacagctg gccatgaaac tgctgacgta tgagctgaag aactggagca   2280

acgccacgtg cctgcagctt gccgtggctg ccaaacaccg cgacttcatc gcgcacacgt   2340

gcagccagat gctgctcacc gacatgtgga tgggccggct ccgcatgcgc aagaactcag   2400

gcctcaaggt aattctggga attctacttc ctccttcaat tctcagcttg gagttcaaga   2460

acaaagacga catgccctat atgtctcagg cccaggaaat ccacctccaa gagaaggagg   2520

cagaagaacc agagaagccc acaaaggaaa aagaggaaga ggacatggag ctcacagcaa   2580

tgttgggacg aaacaacggg gagtcctcca ggaagaagga tgaagaggaa gttcagagca   2640

agcaccggtt aatccccctc ggcagaaaaa tctatgaatt ctacaatgca cccatcgtga   2700

agttctggtt ctacacactg gcgtatatcg gatacctgat gctcttcaac tatatcgtgt   2760

tagtgaagat ggaacgctgg ccgtccaccc aggaatggat cgtaatctcc tatattttca   2820

ccctgggaat agaaaagatg agagagattc tgatgtcaga gccagggaag ttgctacaga   2880

aagtgaaggt atggctgcag gagtactgga atgtcacgga cctcatcgcc atccttctgt   2940

tttctgtcgg aatgatcctt cgtctccaag accagccctt caggagtgac gggagggtca   3000

tctactgcgt gaacatcatt tactggtata tccgtctcct agacatcttc ggcgtgaaca   3060

agtatttggg cccgtatgta atgatgattg gaaaaatgat gatagacatg atgtactttg   3120

tcatcattat gctggtggtt ctgatgagct ttggggtcgc caggcaagcc atcctttttc   3180

ccaatgagga gccatcatgg aaactggcca agaacatctt ctacatgccc tattggatga   3240

tttatgggga agtgtttgcg gaccagatag accctccctg tggacagaat gagacccgag   3300

aggatggtaa aataatccag ctgcctccct gcaagacagg agcttggatc gtgccggcca   3360

tcatggcctg ctacctctta gtggcaaaca tcttgctggt caacctcctc attgctgtct   3420

ttaacaatac attttttgaa gtaaaatcga tatccaacca agtctggaag tttcagaggt   3480

atcagctcat catgactttc catgaaaggc cagttctgcc cccaccactg atcatcttca   3540

gccacatgac catgatattc cagcacctgt gctgccgatg gaggaaacac gagagcgacc   3600

cggatgaaag ggactacggc ctgaaactct tcataaccga tgatgagctc aagaaagtac   3660

atgactttga agagcaatgc atagaagaat acttcagaga aaaggatgat cggttcaact   3720

catctaatga tgagaggata cgggtgactt cagaaagggt ggagaacatg tctatgcggc   3780

tggaggaagt caacgagaga gagcactcca tgaaggcttc actccagacc gtggacatcc   3840

ggctggcgca gctggaagac cttatcgggc gcatggccac ggccctggag cgcctgacag   3900

gtctggagcg ggccgagtcc aacaaaatcc gctcgaggac ctcgtcagac tgcacggacg   3960

ccgcctacat tgtccgtcag agcagcttca acagccagga agggaacacc ttcaagctcc   4020

aagagagtat agaccctgca ggtgaggaga ccatgtcccc aacttctcca accttaatgc   4080

cccgtatgcg aagccattct ttctattcgg tcaatatgaa agacaaaggt ggtatagaaa   4140

agttggaaag tatttttaaa gaaaggtccc tgagcctaca ccgggctact agttcccact   4200

ctgtagcaaa agaacccaaa gctcctgcag cccctgccaa caccttggcc attgttcctg   4260

attccagaag accatcatcg tgtatagaca tctatgtctc tgctatggat gagctccact   4320

gtgatataga ccctctggac aattccgtga acatccttgg gctgggcgag ccaagctttt   4380

caactccagt accttccaca gccccttcaa gtagtgccta tgcaacactt gcacccacag   4440

acagacctcc aagccggagc attgattttg aggacatcac ctccatggac actagatctt   4500

tttcttcaga ctacacccac ctcccagaat gccaaaaccc ctgggactca gagcctccga   4560

tgtaccacac cattgagcgt tccaaaagta gccgctacct agccaccaca ccctttcttc   4620

tagaagaggc tcccattgtg aaatctcata gctttatgtt ttccccctca aggagctatt   4680

atgccaactt tggggtgcct gtaaaaacag cagaatacac aagtattaca gactgtattg   4740

acacaaggtg tgtcaatgcc cctcaagcaa ttgcggacag agctgccttc cctggaggtc   4800

ttggagacaa agtggaggac ttaacttgct gccatccaga gcgagaagca gaactgagtc   4860

accccagctc tgacagtgag gagaatgagg ccaaaggccg cagagccacc attgcaatat   4920

cctcccagga gggtgataac tcagagagaa ccctgtccaa caacatcact gttcccaaga   4980

tagagcgcgc caacagctac tcggcagagg agccaagtgc gccatatgca cacaccagga   5040

agagcttctc catcagtgac aaactcgaca ggcagcggaa cacagcaagc ctgcgaaatc   5100

ccttccagag aagcaagtcc tccaagccgg agggccgagg ggacagcctg tccatgagga   5160

gactgtccag aacatcggct ttccaaagct ttgaaagcaa gcacaactaa accttcttaa   5220

tatccgccac agaaggctca agaatccagc cctaaaattc tctccaactc cagtttttcc   5280

cctttccttg aatcatacct gctttattct tagctgagca aaacaagcaa tgctttggga   5340

ggtgttaact caaaggtgac ttctgggcca cagatcaaga aagcatttga tctgacccag   5400

tgccagacac aggggattta aggcatgttc acacttgctg ggcagggagg gggaagagag   5460

ggagaaggaa gggttagaga tgaatgtgta tccgcagtca cagcagaaag ccatgagagc   5520

aggggaaaca aggggcttcg agcacgctcc atgccaggag gcatctgttg atttctgacc   5580

attatcaaga gttgtaggat gcagggctaa attgcaaaat aaaataaaat agccagcgta   5640

cacaatgaga tattctaaac ttccattctg ttttcttttc acattggctc catcactggt   5700

gactgatgaa gagcatcctc tttattcagt ataagccggc agcaagcagt tctacctaac   5760

gtcccacatc cttctcatgc caacacttct gtaattgatc attataaaga aaaaacaagg   5820

taacagtcat agttcacctg tctcttatct attcacttct ggtgccacaa ctgtttatcc   5880

ttttttgaag aaaataaggg aacagaaatg cctttttgta ttgcaatcga aatgaaagaa   5940

gagttgatgt taaaaaaaca aaagtcaagt gatttattat atacagtggg cgttcaagtc   6000

tagtcgagca agctcaggag aatgtaatta aataatttta tattttttaa tttattttgt   6060

atctcacctg tcatggatga attcattcac tgaatatgta atattgaact taaaaaaaaa   6120

aaaaaaaaaa cagtggacag aactagcctg aaattgccat gtgggatgtt ctgttctcac   6180

cgttcatgtc gtgtgttgtg ctgctgtgtg accgtcatca tttgcatggc tccaccacgt   6240

cctcctgaac acctccaaga cgtaactgcc aatttttcac accactcatc acatgaccat   6300

tttgtatatg aatatatggt tatatgtgga tattttcata cctagagttt tgccatctaa   6360

tctgagctca gcataaattt aattggagtt tttcaagggc tggtatcttt tctatggaaa   6420

tgttccaaag tactttttaa ggaagtttca aaactataaa taaccttaga tttgactggg   6480

agtttggtat caacccaaag ccatcagttg caagcatacc atgaatattt ttcttataga   6540

cagagctata aaaaaagata cagtagacca aaatagaaag caaataaacc atataaagag   6600

ttctatagta tatgccactt atacacatgt atatgcattt atgcagagac acatatttat   6660

atataaaata aatggacata aagagcttt                                     6689


<210>  2467
<211>  1566
<212>  PRT
<213>  Homo sapiens

<400>  2467


Met Tyr Val Arg Val Ser Phe Asp Thr Lys Pro Asp Leu Leu Leu His 
1               5                   10                  15      


Leu Met Thr Lys Glu Trp Gln Leu Glu Leu Pro Lys Leu Leu Ile Ser 
            20                  25                  30          


Val His Gly Gly Leu Gln Asn Phe Glu Leu Gln Pro Lys Leu Lys Gln 
        35                  40                  45              


Val Phe Gly Lys Gly Leu Ile Lys Ala Ala Met Thr Thr Gly Ala Trp 
    50                  55                  60                  


Ile Phe Thr Gly Gly Val Asn Thr Gly Val Ile Arg His Val Gly Asp 
65                  70                  75                  80  


Ala Leu Lys Asp His Ala Ser Lys Ser Arg Gly Lys Ile Cys Thr Ile 
                85                  90                  95      


Gly Ile Ala Pro Trp Gly Ile Val Glu Asn Gln Glu Asp Leu Ile Gly 
            100                 105                 110         


Arg Asp Val Val Arg Pro Tyr Gln Thr Met Ser Asn Pro Met Ser Lys 
        115                 120                 125             


Leu Thr Val Leu Asn Ser Met His Ser His Phe Ile Leu Ala Asp Asn 
    130                 135                 140                 


Gly Thr Thr Gly Lys Tyr Gly Ala Glu Val Lys Leu Arg Arg Gln Leu 
145                 150                 155                 160 


Glu Lys His Ile Ser Leu Gln Lys Ile Asn Thr Arg Ile Gly Gln Gly 
                165                 170                 175     


Val Pro Val Val Ala Leu Ile Val Glu Gly Gly Pro Asn Val Ile Ser 
            180                 185                 190         


Ile Val Leu Glu Tyr Leu Arg Asp Thr Pro Pro Val Pro Val Val Val 
        195                 200                 205             


Cys Asp Gly Ser Gly Arg Ala Ser Asp Ile Leu Ala Phe Gly His Lys 
    210                 215                 220                 


Tyr Ser Glu Glu Gly Gly Leu Ile Asn Glu Ser Leu Arg Asp Gln Leu 
225                 230                 235                 240 


Leu Val Thr Ile Gln Lys Thr Phe Thr Tyr Thr Arg Thr Gln Ala Gln 
                245                 250                 255     


His Leu Phe Ile Ile Leu Met Glu Cys Met Lys Lys Lys Glu Leu Ile 
            260                 265                 270         


Thr Val Phe Arg Met Gly Ser Glu Gly His Gln Asp Ile Asp Leu Ala 
        275                 280                 285             


Ile Leu Thr Ala Leu Leu Lys Gly Ala Asn Ala Ser Ala Pro Asp Gln 
    290                 295                 300                 


Leu Ser Leu Ala Leu Ala Trp Asn Arg Val Asp Ile Ala Arg Ser Gln 
305                 310                 315                 320 


Ile Phe Ile Tyr Gly Gln Gln Trp Pro Val Gly Ser Leu Glu Gln Ala 
                325                 330                 335     


Met Leu Asp Ala Leu Val Leu Asp Arg Val Asp Phe Val Lys Leu Leu 
            340                 345                 350         


Ile Glu Asn Gly Val Ser Met His Arg Phe Leu Thr Ile Ser Arg Leu 
        355                 360                 365             


Glu Glu Leu Tyr Asn Thr Arg His Gly Pro Ser Asn Thr Leu Tyr His 
    370                 375                 380                 


Leu Val Arg Asp Val Lys Lys Arg Glu Tyr Pro Gly Phe Gly Trp Ile 
385                 390                 395                 400 


Tyr Phe Lys Gly Asn Leu Pro Pro Asp Tyr Arg Ile Ser Leu Ile Asp 
                405                 410                 415     


Ile Gly Leu Val Ile Glu Tyr Leu Met Gly Gly Ala Tyr Arg Cys Asn 
            420                 425                 430         


Tyr Thr Arg Lys Arg Phe Arg Thr Leu Tyr His Asn Leu Phe Gly Pro 
        435                 440                 445             


Lys Arg Pro Lys Ala Leu Lys Leu Leu Gly Met Glu Asp Asp Ile Pro 
    450                 455                 460                 


Leu Arg Arg Gly Arg Lys Thr Thr Lys Lys Arg Glu Glu Glu Val Asp 
465                 470                 475                 480 


Ile Asp Leu Asp Asp Pro Glu Ile Asn His Phe Pro Phe Pro Phe His 
                485                 490                 495     


Glu Leu Met Val Trp Ala Val Leu Met Lys Arg Gln Lys Met Ala Leu 
            500                 505                 510         


Phe Phe Trp Gln His Gly Glu Glu Ala Met Ala Lys Ala Leu Val Ala 
        515                 520                 525             


Cys Lys Leu Cys Lys Ala Met Ala His Glu Ala Ser Glu Asn Asp Met 
    530                 535                 540                 


Val Asp Asp Ile Ser Gln Glu Leu Asn His Asn Ser Arg Asp Phe Gly 
545                 550                 555                 560 


Gln Leu Ala Val Glu Leu Leu Asp Gln Ser Tyr Lys Gln Asp Glu Gln 
                565                 570                 575     


Leu Ala Met Lys Leu Leu Thr Tyr Glu Leu Lys Asn Trp Ser Asn Ala 
            580                 585                 590         


Thr Cys Leu Gln Leu Ala Val Ala Ala Lys His Arg Asp Phe Ile Ala 
        595                 600                 605             


His Thr Cys Ser Gln Met Leu Leu Thr Asp Met Trp Met Gly Arg Leu 
    610                 615                 620                 


Arg Met Arg Lys Asn Ser Gly Leu Lys Val Ile Leu Gly Ile Leu Leu 
625                 630                 635                 640 


Pro Pro Ser Ile Leu Ser Leu Glu Phe Lys Asn Lys Asp Asp Met Pro 
                645                 650                 655     


Tyr Met Ser Gln Ala Gln Glu Ile His Leu Gln Glu Lys Glu Ala Glu 
            660                 665                 670         


Glu Pro Glu Lys Pro Thr Lys Glu Lys Glu Glu Glu Asp Met Glu Leu 
        675                 680                 685             


Thr Ala Met Leu Gly Arg Asn Asn Gly Glu Ser Ser Arg Lys Lys Asp 
    690                 695                 700                 


Glu Glu Glu Val Gln Ser Lys His Arg Leu Ile Pro Leu Gly Arg Lys 
705                 710                 715                 720 


Ile Tyr Glu Phe Tyr Asn Ala Pro Ile Val Lys Phe Trp Phe Tyr Thr 
                725                 730                 735     


Leu Ala Tyr Ile Gly Tyr Leu Met Leu Phe Asn Tyr Ile Val Leu Val 
            740                 745                 750         


Lys Met Glu Arg Trp Pro Ser Thr Gln Glu Trp Ile Val Ile Ser Tyr 
        755                 760                 765             


Ile Phe Thr Leu Gly Ile Glu Lys Met Arg Glu Ile Leu Met Ser Glu 
    770                 775                 780                 


Pro Gly Lys Leu Leu Gln Lys Val Lys Val Trp Leu Gln Glu Tyr Trp 
785                 790                 795                 800 


Asn Val Thr Asp Leu Ile Ala Ile Leu Leu Phe Ser Val Gly Met Ile 
                805                 810                 815     


Leu Arg Leu Gln Asp Gln Pro Phe Arg Ser Asp Gly Arg Val Ile Tyr 
            820                 825                 830         


Cys Val Asn Ile Ile Tyr Trp Tyr Ile Arg Leu Leu Asp Ile Phe Gly 
        835                 840                 845             


Val Asn Lys Tyr Leu Gly Pro Tyr Val Met Met Ile Gly Lys Met Met 
    850                 855                 860                 


Ile Asp Met Met Tyr Phe Val Ile Ile Met Leu Val Val Leu Met Ser 
865                 870                 875                 880 


Phe Gly Val Ala Arg Gln Ala Ile Leu Phe Pro Asn Glu Glu Pro Ser 
                885                 890                 895     


Trp Lys Leu Ala Lys Asn Ile Phe Tyr Met Pro Tyr Trp Met Ile Tyr 
            900                 905                 910         


Gly Glu Val Phe Ala Asp Gln Ile Asp Pro Pro Cys Gly Gln Asn Glu 
        915                 920                 925             


Thr Arg Glu Asp Gly Lys Ile Ile Gln Leu Pro Pro Cys Lys Thr Gly 
    930                 935                 940                 


Ala Trp Ile Val Pro Ala Ile Met Ala Cys Tyr Leu Leu Val Ala Asn 
945                 950                 955                 960 


Ile Leu Leu Val Asn Leu Leu Ile Ala Val Phe Asn Asn Thr Phe Phe 
                965                 970                 975     


Glu Val Lys Ser Ile Ser Asn Gln Val Trp Lys Phe Gln Arg Tyr Gln 
            980                 985                 990         


Leu Ile Met Thr Phe His Glu Arg  Pro Val Leu Pro Pro  Pro Leu Ile 
        995                 1000                 1005             


Ile Phe  Ser His Met Thr Met  Ile Phe Gln His Leu  Cys Cys Arg 
    1010                 1015                 1020             


Trp Arg  Lys His Glu Ser Asp  Pro Asp Glu Arg Asp  Tyr Gly Leu 
    1025                 1030                 1035             


Lys Leu  Phe Ile Thr Asp Asp  Glu Leu Lys Lys Val  His Asp Phe 
    1040                 1045                 1050             


Glu Glu  Gln Cys Ile Glu Glu  Tyr Phe Arg Glu Lys  Asp Asp Arg 
    1055                 1060                 1065             


Phe Asn  Ser Ser Asn Asp Glu  Arg Ile Arg Val Thr  Ser Glu Arg 
    1070                 1075                 1080             


Val Glu  Asn Met Ser Met Arg  Leu Glu Glu Val Asn  Glu Arg Glu 
    1085                 1090                 1095             


His Ser  Met Lys Ala Ser Leu  Gln Thr Val Asp Ile  Arg Leu Ala 
    1100                 1105                 1110             


Gln Leu  Glu Asp Leu Ile Gly  Arg Met Ala Thr Ala  Leu Glu Arg 
    1115                 1120                 1125             


Leu Thr  Gly Leu Glu Arg Ala  Glu Ser Asn Lys Ile  Arg Ser Arg 
    1130                 1135                 1140             


Thr Ser  Ser Asp Cys Thr Asp  Ala Ala Tyr Ile Val  Arg Gln Ser 
    1145                 1150                 1155             


Ser Phe  Asn Ser Gln Glu Gly  Asn Thr Phe Lys Leu  Gln Glu Ser 
    1160                 1165                 1170             


Ile Asp  Pro Ala Gly Glu Glu  Thr Met Ser Pro Thr  Ser Pro Thr 
    1175                 1180                 1185             


Leu Met  Pro Arg Met Arg Ser  His Ser Phe Tyr Ser  Val Asn Met 
    1190                 1195                 1200             


Lys Asp  Lys Gly Gly Ile Glu  Lys Leu Glu Ser Ile  Phe Lys Glu 
    1205                 1210                 1215             


Arg Ser  Leu Ser Leu His Arg  Ala Thr Ser Ser His  Ser Val Ala 
    1220                 1225                 1230             


Lys Glu  Pro Lys Ala Pro Ala  Ala Pro Ala Asn Thr  Leu Ala Ile 
    1235                 1240                 1245             


Val Pro  Asp Ser Arg Arg Pro  Ser Ser Cys Ile Asp  Ile Tyr Val 
    1250                 1255                 1260             


Ser Ala  Met Asp Glu Leu His  Cys Asp Ile Asp Pro  Leu Asp Asn 
    1265                 1270                 1275             


Ser Val  Asn Ile Leu Gly Leu  Gly Glu Pro Ser Phe  Ser Thr Pro 
    1280                 1285                 1290             


Val Pro  Ser Thr Ala Pro Ser  Ser Ser Ala Tyr Ala  Thr Leu Ala 
    1295                 1300                 1305             


Pro Thr  Asp Arg Pro Pro Ser  Arg Ser Ile Asp Phe  Glu Asp Ile 
    1310                 1315                 1320             


Thr Ser  Met Asp Thr Arg Ser  Phe Ser Ser Asp Tyr  Thr His Leu 
    1325                 1330                 1335             


Pro Glu  Cys Gln Asn Pro Trp  Asp Ser Glu Pro Pro  Met Tyr His 
    1340                 1345                 1350             


Thr Ile  Glu Arg Ser Lys Ser  Ser Arg Tyr Leu Ala  Thr Thr Pro 
    1355                 1360                 1365             


Phe Leu  Leu Glu Glu Ala Pro  Ile Val Lys Ser His  Ser Phe Met 
    1370                 1375                 1380             


Phe Ser  Pro Ser Arg Ser Tyr  Tyr Ala Asn Phe Gly  Val Pro Val 
    1385                 1390                 1395             


Lys Thr  Ala Glu Tyr Thr Ser  Ile Thr Asp Cys Ile  Asp Thr Arg 
    1400                 1405                 1410             


Cys Val  Asn Ala Pro Gln Ala  Ile Ala Asp Arg Ala  Ala Phe Pro 
    1415                 1420                 1425             


Gly Gly  Leu Gly Asp Lys Val  Glu Asp Leu Thr Cys  Cys His Pro 
    1430                 1435                 1440             


Glu Arg  Glu Ala Glu Leu Ser  His Pro Ser Ser Asp  Ser Glu Glu 
    1445                 1450                 1455             


Asn Glu  Ala Lys Gly Arg Arg  Ala Thr Ile Ala Ile  Ser Ser Gln 
    1460                 1465                 1470             


Glu Gly  Asp Asn Ser Glu Arg  Thr Leu Ser Asn Asn  Ile Thr Val 
    1475                 1480                 1485             


Pro Lys  Ile Glu Arg Ala Asn  Ser Tyr Ser Ala Glu  Glu Pro Ser 
    1490                 1495                 1500             


Ala Pro  Tyr Ala His Thr Arg  Lys Ser Phe Ser Ile  Ser Asp Lys 
    1505                 1510                 1515             


Leu Asp  Arg Gln Arg Asn Thr  Ala Ser Leu Arg Asn  Pro Phe Gln 
    1520                 1525                 1530             


Arg Ser  Lys Ser Ser Lys Pro  Glu Gly Arg Gly Asp  Ser Leu Ser 
    1535                 1540                 1545             


Met Arg  Arg Leu Ser Arg Thr  Ser Ala Phe Gln Ser  Phe Glu Ser 
    1550                 1555                 1560             


Lys His  Asn 
    1565     

<210>  2468
<211>  5177
<212>  DNA
<213>  Homo sapiens

<400>  2468
tccgaccaca ggctgttttg tgcaggctgt ccctcttctt caaaatcgtg catcccctcc     60

ccgaagcagc aggcagtgtg cctccattca gccacatttg gtatgcatga gcacggctgc    120

agagagaggg gaggtggctg ttttaagaag gttcaggggc tcaggcaagg ctacttgact    180

agtcttccaa gttccaggaa gcctctgccc taatggaatt tgcaggtgtg gagatgacca    240

tgggatgcca gagccgtggg ggaccgttta ttttctaggc attgctcagg ttttcagttt    300

cttgttttcc tggtggaatt tggaaggggt catgaatcag gctgatgctc ctcgacccct    360

aaactggacc atccggaagc tgtgccacgc agcctttctt ccatctgtca gacttctgaa    420

ggctcagaaa tcctggatag aaagagcatt ttataaaaga gaatgtgtcc acatcatacc    480

cagcaccaaa gacccccata ggtgttgctg tgggcgtctg ataggccagc atgttggcct    540

cacccccagt atctccgtgc ttcagaatga gaaaaatgaa agtcgcctct cccgaaatga    600

catccagtct gaaaagtggt ccatcagcaa acacactcaa ctcagcccta cggatgcttt    660

tgggaccatt gagttccaag gaggtggcca ttccaacaaa gccatgtatg tgcgagtatc    720

ttttgataca aaacctgatc tcctcttaca cctgatgacc aaggaatggc agttggagct    780

tcccaagctt ctcatctctg tccatggggg cctgcagaac tttgaactcc agccaaaact    840

caagcaagtc tttgggaaag ggctcatcaa agcagcaatg acaactggag cgtggatatt    900

cactggaggg gttaacacag gtgttattcg tcatgttggc gatgccttga aggatcatgc    960

ctctaagtct cgaggaaaga tatgcaccat aggtattgcc ccctggggaa ttgtggaaaa   1020

ccaggaggac ctcattggaa gagatgttgt ccggccatac cagaccatgt ccaatcccat   1080

gagcaagctc actgttctca acagcatgca ttcccacttc attctggctg acaacgggac   1140

cactggaaaa tatggagcag aggtgaaact tcgaagacaa ctggaaaagc atatttcact   1200

ccagaagata aacacaagaa tcggtcaagg tgttcctgtg gtggcactca tagtggaagg   1260

aggacccaat gtgatctcga ttgttttgga gtaccttcga gacacccctc ccgtgccagt   1320

ggttgtctgt gatgggagtg gacgggcatc ggacatcctg gcctttgggc ataaatactc   1380

agaagaaggc ggactgataa atgaatcttt gagggaccag ctgttggtga ctatacagaa   1440

gactttcaca tacactcgaa cccaagctca gcatctgttc atcatcctca tggagtgcat   1500

gaagaagaag gaattgatta cggtatttcg gatgggatca gaaggacacc aggacattga   1560

tttggctatc ctgacagctt tactcaaagg agccaatgcc tcggccccag accaactgag   1620

cttagcttta gcctggaaca gagtcgacat cgctcgcagc cagatcttta tttacgggca   1680

acagtggccg gtgggatctc tggagcaagc catgttggat gccttagttc tggacagagt   1740

ggattttgtg aaattactca tagagaatgg agtaagcatg caccgttttc tcaccatctc   1800

cagactagag gaattgtaca atacgagaca tgggccctca aatacattgt accacttggt   1860

cagggatgtc aaaaagggga acctgccccc agactacaga atcagcctga ttgacatcgg   1920

cctggtgatc gagtacctga tgggcggggc ttatcgctgc aactacacgc gcaagcgctt   1980

ccggaccctc taccacaacc tcttcggccc caagaggccc aaagccttga aactgctggg   2040

aatggaggat gatattccct tgaggcgagg aagaaagaca accaagaaac gtgaagaaga   2100

ggtggacatt gacttggatg atcctgagat caaccacttc cccttccctt tccatgagct   2160

catggtgtgg gctgttctca tgaagcggca gaagatggcc ctgttcttct ggcagcacgg   2220

tgaggaggcc atggccaagg ccctggtggc ctgcaagctc tgcaaagcca tggctcatga   2280

ggcctctgag aacgacatgg ttgacgacat ttcccaggag ctgaatcaca attccagaga   2340

ctttggccag ctggctgtgg agctcctgga ccagtcctac aagcaggacg aacagctggc   2400

catgaaactg ctgacgtatg agctgaagaa ctggagcaac gccacgtgcc tgcagcttgc   2460

cgtggctgcc aaacaccgcg acttcatcgc gcacacgtgc agccagatgc tgctcaccga   2520

catgtggatg ggccggctcc gcatgcgcaa gaactcaggc ctcaaggtaa ttctgggaat   2580

tctacttcct ccttcaattc tcagcttgga gttcaagaac aaagacgaca tgccctatat   2640

gtctcaggcc caggaaatcc acctccaaga gaaggaggca gaagaaccag agaagcccac   2700

aaaggaaaaa gaggaagagg acatggagct cacagcaatg ttgggacgaa acaacgggga   2760

gtcctccagg aagaaggatg aagaggaagt tcagagcaag caccggttaa tccccctcgg   2820

cagaaaaatc tatgaattct acaatgcacc catcgtgaag ttctggttct acacactggc   2880

gtatatcgga tacctgatgc tcttcaacta tatcgtgtta gtgaagatgg aacgctggcc   2940

gtccacccag gaatggatcg taatctccta tattttcacc ctgggaatag aaaagatgag   3000

agagattctg atgtcagagc cagggaagtt gctacagaaa gtgaaggtat ggctgcagga   3060

gtactggaat gtcacggacc tcatcgccat ccttctgttt tctgtcggaa tgatccttcg   3120

tctccaagac cagcccttca ggagtgacgg gagggtcatc tactgcgtga acatcattta   3180

ctggtatatc cgtctcctag acatcttcgg cgtgaacaag tatttgggcc cgtatgtaat   3240

gatgattgga aaaatgatga tagacatgat gtactttgtc atcattatgc tggtggttct   3300

gatgagcttt ggggtcgcca ggcaagccat cctttttccc aatgaggagc catcatggaa   3360

actggccaag aacatcttct acatgcccta ttggatgatt tatggggaag tgtttgcgga   3420

ccagatagac cctccctgtg gacagaatga gacccgagag gatggtaaaa taatccagct   3480

gcctccctgc aagacaggag cttggatcgt gccggccatc atggcctgct acctcttagt   3540

ggcaaacatc ttgctggtca acctcctcat tgctgtcttt aacaatacat tttttgaagt   3600

aaaatcgata tccaaccaag tctggaagtt tcagaggtat cagctcatca tgactttcca   3660

tgaaaggcca gttctgcccc caccactgat catcttcagc cacatgacca tgatattcca   3720

gcacctgtgc tgccgatgga ggaaacacga gagcgacccg gatgaaaggg actacggcct   3780

gaaactcttc ataaccgatg atgagctcaa gaaagtacat gactttgaag agcaatgcat   3840

agaagaatac ttcagagaaa aggatgatcg gttcaactca tctaatgatg agaggatacg   3900

ggtgacttca gaaagggtgg agaacatgtc tatgcggctg gaggaagtca acgagagaga   3960

gcactccatg aaggcttcac tccagaccgt ggacatccgg ctggcgcagc tggaagacct   4020

tatcgggcgc atggccacgg ccctggagcg cctgacaggt ctggagcggg ccgagtccaa   4080

caaaatccgc tcgaggacct cgtcagactg cacggacgcc gcctacattg tccgtcagag   4140

cagcttcaac agccaggaag ggaacacctt caagctccaa gagagtatag accctgcaga   4200

gcatcctctt tattcagtat aagccggcag caagcagttc tacctaacgt cccacatcct   4260

tctcatgcca acacttctgt aattgatcat tataaagaaa aaacaaggta acagtcatag   4320

ttcacctgtc tcttatctat tcacttctgg tgccacaact gtttatcctt ttttgaagaa   4380

aataagggaa cagaaatgcc tttttgtatt gcaatcgaaa tgaaagaaga gttgatgtta   4440

aaaaaacaaa agtcaagtga tttattatat acagtgggcg ttcaagtcta gtcgagcaag   4500

ctcaggagaa tgtaattaaa taattttata ttttttaatt tattttgtat ctcacctgtc   4560

atggatgaat tcattcactg aatatgtaat attgaactta aaaaaaaaaa aaaaaaaaca   4620

gtggacagaa ctagcctgaa attgccatgt gggatgttct gttctcaccg ttcatgtcgt   4680

gtgttgtgct gctgtgtgac cgtcatcatt tgcatggctc caccacgtcc tcctgaacac   4740

ctccaagacg taactgccaa tttttcacac cactcatcac atgaccattt tgtatatgaa   4800

tatatggtta tatgtggata ttttcatacc tagagttttg ccatctaatc tgagctcagc   4860

ataaatttaa ttggagtttt tcaagggctg gtatcttttc tatggaaatg ttccaaagta   4920

ctttttaagg aagtttcaaa actataaata accttagatt tgactgggag tttggtatca   4980

acccaaagcc atcagttgca agcataccat gaatattttt cttatagaca gagctataaa   5040

aaaagataca gtagaccaaa atagaaagca aataaaccat ataaagagtt ctatagtata   5100

tgccacttat acacatgtat atgcatttat gcagagacac atatttatat ataaaataaa   5160

tggacataaa gagcttt                                                  5177


<210>  2469
<211>  1325
<212>  PRT
<213>  Homo sapiens

<400>  2469


Met Pro Glu Pro Trp Gly Thr Val Tyr Phe Leu Gly Ile Ala Gln Val 
1               5                   10                  15      


Phe Ser Phe Leu Phe Ser Trp Trp Asn Leu Glu Gly Val Met Asn Gln 
            20                  25                  30          


Ala Asp Ala Pro Arg Pro Leu Asn Trp Thr Ile Arg Lys Leu Cys His 
        35                  40                  45              


Ala Ala Phe Leu Pro Ser Val Arg Leu Leu Lys Ala Gln Lys Ser Trp 
    50                  55                  60                  


Ile Glu Arg Ala Phe Tyr Lys Arg Glu Cys Val His Ile Ile Pro Ser 
65                  70                  75                  80  


Thr Lys Asp Pro His Arg Cys Cys Cys Gly Arg Leu Ile Gly Gln His 
                85                  90                  95      


Val Gly Leu Thr Pro Ser Ile Ser Val Leu Gln Asn Glu Lys Asn Glu 
            100                 105                 110         


Ser Arg Leu Ser Arg Asn Asp Ile Gln Ser Glu Lys Trp Ser Ile Ser 
        115                 120                 125             


Lys His Thr Gln Leu Ser Pro Thr Asp Ala Phe Gly Thr Ile Glu Phe 
    130                 135                 140                 


Gln Gly Gly Gly His Ser Asn Lys Ala Met Tyr Val Arg Val Ser Phe 
145                 150                 155                 160 


Asp Thr Lys Pro Asp Leu Leu Leu His Leu Met Thr Lys Glu Trp Gln 
                165                 170                 175     


Leu Glu Leu Pro Lys Leu Leu Ile Ser Val His Gly Gly Leu Gln Asn 
            180                 185                 190         


Phe Glu Leu Gln Pro Lys Leu Lys Gln Val Phe Gly Lys Gly Leu Ile 
        195                 200                 205             


Lys Ala Ala Met Thr Thr Gly Ala Trp Ile Phe Thr Gly Gly Val Asn 
    210                 215                 220                 


Thr Gly Val Ile Arg His Val Gly Asp Ala Leu Lys Asp His Ala Ser 
225                 230                 235                 240 


Lys Ser Arg Gly Lys Ile Cys Thr Ile Gly Ile Ala Pro Trp Gly Ile 
                245                 250                 255     


Val Glu Asn Gln Glu Asp Leu Ile Gly Arg Asp Val Val Arg Pro Tyr 
            260                 265                 270         


Gln Thr Met Ser Asn Pro Met Ser Lys Leu Thr Val Leu Asn Ser Met 
        275                 280                 285             


His Ser His Phe Ile Leu Ala Asp Asn Gly Thr Thr Gly Lys Tyr Gly 
    290                 295                 300                 


Ala Glu Val Lys Leu Arg Arg Gln Leu Glu Lys His Ile Ser Leu Gln 
305                 310                 315                 320 


Lys Ile Asn Thr Arg Ile Gly Gln Gly Val Pro Val Val Ala Leu Ile 
                325                 330                 335     


Val Glu Gly Gly Pro Asn Val Ile Ser Ile Val Leu Glu Tyr Leu Arg 
            340                 345                 350         


Asp Thr Pro Pro Val Pro Val Val Val Cys Asp Gly Ser Gly Arg Ala 
        355                 360                 365             


Ser Asp Ile Leu Ala Phe Gly His Lys Tyr Ser Glu Glu Gly Gly Leu 
    370                 375                 380                 


Ile Asn Glu Ser Leu Arg Asp Gln Leu Leu Val Thr Ile Gln Lys Thr 
385                 390                 395                 400 


Phe Thr Tyr Thr Arg Thr Gln Ala Gln His Leu Phe Ile Ile Leu Met 
                405                 410                 415     


Glu Cys Met Lys Lys Lys Glu Leu Ile Thr Val Phe Arg Met Gly Ser 
            420                 425                 430         


Glu Gly His Gln Asp Ile Asp Leu Ala Ile Leu Thr Ala Leu Leu Lys 
        435                 440                 445             


Gly Ala Asn Ala Ser Ala Pro Asp Gln Leu Ser Leu Ala Leu Ala Trp 
    450                 455                 460                 


Asn Arg Val Asp Ile Ala Arg Ser Gln Ile Phe Ile Tyr Gly Gln Gln 
465                 470                 475                 480 


Trp Pro Val Gly Ser Leu Glu Gln Ala Met Leu Asp Ala Leu Val Leu 
                485                 490                 495     


Asp Arg Val Asp Phe Val Lys Leu Leu Ile Glu Asn Gly Val Ser Met 
            500                 505                 510         


His Arg Phe Leu Thr Ile Ser Arg Leu Glu Glu Leu Tyr Asn Thr Arg 
        515                 520                 525             


His Gly Pro Ser Asn Thr Leu Tyr His Leu Val Arg Asp Val Lys Lys 
    530                 535                 540                 


Gly Asn Leu Pro Pro Asp Tyr Arg Ile Ser Leu Ile Asp Ile Gly Leu 
545                 550                 555                 560 


Val Ile Glu Tyr Leu Met Gly Gly Ala Tyr Arg Cys Asn Tyr Thr Arg 
                565                 570                 575     


Lys Arg Phe Arg Thr Leu Tyr His Asn Leu Phe Gly Pro Lys Arg Pro 
            580                 585                 590         


Lys Ala Leu Lys Leu Leu Gly Met Glu Asp Asp Ile Pro Leu Arg Arg 
        595                 600                 605             


Gly Arg Lys Thr Thr Lys Lys Arg Glu Glu Glu Val Asp Ile Asp Leu 
    610                 615                 620                 


Asp Asp Pro Glu Ile Asn His Phe Pro Phe Pro Phe His Glu Leu Met 
625                 630                 635                 640 


Val Trp Ala Val Leu Met Lys Arg Gln Lys Met Ala Leu Phe Phe Trp 
                645                 650                 655     


Gln His Gly Glu Glu Ala Met Ala Lys Ala Leu Val Ala Cys Lys Leu 
            660                 665                 670         


Cys Lys Ala Met Ala His Glu Ala Ser Glu Asn Asp Met Val Asp Asp 
        675                 680                 685             


Ile Ser Gln Glu Leu Asn His Asn Ser Arg Asp Phe Gly Gln Leu Ala 
    690                 695                 700                 


Val Glu Leu Leu Asp Gln Ser Tyr Lys Gln Asp Glu Gln Leu Ala Met 
705                 710                 715                 720 


Lys Leu Leu Thr Tyr Glu Leu Lys Asn Trp Ser Asn Ala Thr Cys Leu 
                725                 730                 735     


Gln Leu Ala Val Ala Ala Lys His Arg Asp Phe Ile Ala His Thr Cys 
            740                 745                 750         


Ser Gln Met Leu Leu Thr Asp Met Trp Met Gly Arg Leu Arg Met Arg 
        755                 760                 765             


Lys Asn Ser Gly Leu Lys Val Ile Leu Gly Ile Leu Leu Pro Pro Ser 
    770                 775                 780                 


Ile Leu Ser Leu Glu Phe Lys Asn Lys Asp Asp Met Pro Tyr Met Ser 
785                 790                 795                 800 


Gln Ala Gln Glu Ile His Leu Gln Glu Lys Glu Ala Glu Glu Pro Glu 
                805                 810                 815     


Lys Pro Thr Lys Glu Lys Glu Glu Glu Asp Met Glu Leu Thr Ala Met 
            820                 825                 830         


Leu Gly Arg Asn Asn Gly Glu Ser Ser Arg Lys Lys Asp Glu Glu Glu 
        835                 840                 845             


Val Gln Ser Lys His Arg Leu Ile Pro Leu Gly Arg Lys Ile Tyr Glu 
    850                 855                 860                 


Phe Tyr Asn Ala Pro Ile Val Lys Phe Trp Phe Tyr Thr Leu Ala Tyr 
865                 870                 875                 880 


Ile Gly Tyr Leu Met Leu Phe Asn Tyr Ile Val Leu Val Lys Met Glu 
                885                 890                 895     


Arg Trp Pro Ser Thr Gln Glu Trp Ile Val Ile Ser Tyr Ile Phe Thr 
            900                 905                 910         


Leu Gly Ile Glu Lys Met Arg Glu Ile Leu Met Ser Glu Pro Gly Lys 
        915                 920                 925             


Leu Leu Gln Lys Val Lys Val Trp Leu Gln Glu Tyr Trp Asn Val Thr 
    930                 935                 940                 


Asp Leu Ile Ala Ile Leu Leu Phe Ser Val Gly Met Ile Leu Arg Leu 
945                 950                 955                 960 


Gln Asp Gln Pro Phe Arg Ser Asp Gly Arg Val Ile Tyr Cys Val Asn 
                965                 970                 975     


Ile Ile Tyr Trp Tyr Ile Arg Leu Leu Asp Ile Phe Gly Val Asn Lys 
            980                 985                 990         


Tyr Leu Gly Pro Tyr Val Met Met  Ile Gly Lys Met Met  Ile Asp Met 
        995                 1000                 1005             


Met Tyr  Phe Val Ile Ile Met  Leu Val Val Leu Met  Ser Phe Gly 
    1010                 1015                 1020             


Val Ala  Arg Gln Ala Ile Leu  Phe Pro Asn Glu Glu  Pro Ser Trp 
    1025                 1030                 1035             


Lys Leu  Ala Lys Asn Ile Phe  Tyr Met Pro Tyr Trp  Met Ile Tyr 
    1040                 1045                 1050             


Gly Glu  Val Phe Ala Asp Gln  Ile Asp Pro Pro Cys  Gly Gln Asn 
    1055                 1060                 1065             


Glu Thr  Arg Glu Asp Gly Lys  Ile Ile Gln Leu Pro  Pro Cys Lys 
    1070                 1075                 1080             


Thr Gly  Ala Trp Ile Val Pro  Ala Ile Met Ala Cys  Tyr Leu Leu 
    1085                 1090                 1095             


Val Ala  Asn Ile Leu Leu Val  Asn Leu Leu Ile Ala  Val Phe Asn 
    1100                 1105                 1110             


Asn Thr  Phe Phe Glu Val Lys  Ser Ile Ser Asn Gln  Val Trp Lys 
    1115                 1120                 1125             


Phe Gln  Arg Tyr Gln Leu Ile  Met Thr Phe His Glu  Arg Pro Val 
    1130                 1135                 1140             


Leu Pro  Pro Pro Leu Ile Ile  Phe Ser His Met Thr  Met Ile Phe 
    1145                 1150                 1155             


Gln His  Leu Cys Cys Arg Trp  Arg Lys His Glu Ser  Asp Pro Asp 
    1160                 1165                 1170             


Glu Arg  Asp Tyr Gly Leu Lys  Leu Phe Ile Thr Asp  Asp Glu Leu 
    1175                 1180                 1185             


Lys Lys  Val His Asp Phe Glu  Glu Gln Cys Ile Glu  Glu Tyr Phe 
    1190                 1195                 1200             


Arg Glu  Lys Asp Asp Arg Phe  Asn Ser Ser Asn Asp  Glu Arg Ile 
    1205                 1210                 1215             


Arg Val  Thr Ser Glu Arg Val  Glu Asn Met Ser Met  Arg Leu Glu 
    1220                 1225                 1230             


Glu Val  Asn Glu Arg Glu His  Ser Met Lys Ala Ser  Leu Gln Thr 
    1235                 1240                 1245             


Val Asp  Ile Arg Leu Ala Gln  Leu Glu Asp Leu Ile  Gly Arg Met 
    1250                 1255                 1260             


Ala Thr  Ala Leu Glu Arg Leu  Thr Gly Leu Glu Arg  Ala Glu Ser 
    1265                 1270                 1275             


Asn Lys  Ile Arg Ser Arg Thr  Ser Ser Asp Cys Thr  Asp Ala Ala 
    1280                 1285                 1290             


Tyr Ile  Val Arg Gln Ser Ser  Phe Asn Ser Gln Glu  Gly Asn Thr 
    1295                 1300                 1305             


Phe Lys  Leu Gln Glu Ser Ile  Asp Pro Ala Glu His  Pro Leu Tyr 
    1310                 1315                 1320             


Ser Val  
    1325 

<210>  2470
<211>  6847
<212>  DNA
<213>  Homo sapiens

<400>  2470
tccgaccaca ggctgttttg tgcaggctgt ccctcttctt caaaatcgtg catcccctcc     60

ccgaagcagc aggcagtgtg cctccattca gccacatttg gtatgcatga gcacggctgc    120

agagagaggg gaggtggctg ttttaagaag gttcaggggc tcaggcaagg ctacttgact    180

agtcttccaa gttccaggaa gcctctgccc taatggaatt tgcaggtgtg gagatgacca    240

tgggatgcca gagccgtggg ggaccgttta ttttctaggc attgctcagg ttttcagttt    300

cttgttttcc tggtggaatt tggaaggggt catgaatcag gctgatgctc ctcgacccct    360

aaactggacc atccggaagc tgtgccacgc agcctttctt ccatctgtca gacttctgaa    420

ggctcagaaa tcctggatag aaagagcatt ttataaaaga gaatgtgtcc acatcatacc    480

cagcaccaaa gacccccata ggtgttgctg tgggcgtctg ataggccagc atgttggcct    540

cacccccagt atctccgtgc ttcagaatga gaaaaatgaa agtcgcctct cccgaaatga    600

catccagtct gaaaagtggt ccatcagcaa acacactcaa ctcagcccta cggatgcttt    660

tgggaccatt gagttccaag gaggtggcca ttccaacaaa gccatgtatg tgcgagtatc    720

ttttgataca aaacctgatc tcctcttaca cctgatgacc aaggaatggc agttggagct    780

tcccaagctt ctcatctctg tccatggggg cctgcagaac tttgaactcc agccaaaact    840

caagcaagtc tttgggaaag ggctcatcaa agcagcaatg acaactggag cgtggatatt    900

cactggaggg gttaacacag gtgttattcg tcatgttggc gatgccttga aggatcatgc    960

ctctaagtct cgaggaaaga tatgcaccat aggtattgcc ccctggggaa ttgtggaaaa   1020

ccaggaggac ctcattggaa gagatgttgt ccggccatac cagaccatgt ccaatcccat   1080

gagcaagctc actgttctca acagcatgca ttcccacttc attctggctg acaacgggac   1140

cactggaaaa tatggagcag aggtgaaact tcgaagacaa ctggaaaagc atatttcact   1200

ccagaagata aacacaagaa tcggtcaagg tgttcctgtg gtggcactca tagtggaagg   1260

aggacccaat gtgatctcga ttgttttgga gtaccttcga gacacccctc ccgtgccagt   1320

ggttgtctgt gatgggagtg gacgggcatc ggacatcctg gcctttgggc ataaatactc   1380

agaagaaggc ggactgataa atgaatcttt gagggaccag ctgttggtga ctatacagaa   1440

gactttcaca tacactcgaa cccaagctca gcatctgttc atcatcctca tggagtgcat   1500

gaagaagaag gaattgatta cggtatttcg gatgggatca gaaggacacc aggacattga   1560

tttggctatc ctgacagctt tactcaaagg agccaatgcc tcggccccag accaactgag   1620

cttagcttta gcctggaaca gagtcgacat cgctcgcagc cagatcttta tttacgggca   1680

acagtggccg gtgggatctc tggagcaagc catgttggat gccttagttc tggacagagt   1740

ggattttgtg aaattactca tagagaatgg agtaagcatg caccgttttc tcaccatctc   1800

cagactagag gaattgtaca atacgagaca tgggccctca aatacattgt accacttggt   1860

cagggatgtc aaaaagggga acctgccccc agactacaga atcagcctga ttgacatcgg   1920

cctggtgatc gagtacctga tgggcggggc ttatcgctgc aactacacgc gcaagcgctt   1980

ccggaccctc taccacaacc tcttcggccc caagaggccc aaagccttga aactgctggg   2040

aatggaggat gatattccct tgaggcgagg aagaaagaca accaagaaac gtgaagaaga   2100

ggtggacatt gacttggatg atcctgagat caaccacttc cccttccctt tccatgagct   2160

catggtgtgg gctgttctca tgaagcggca gaagatggcc ctgttcttct ggcagcacgg   2220

tgaggaggcc atggccaagg ccctggtggc ctgcaagctc tgcaaagcca tggctcatga   2280

ggcctctgag aacgacatgg ttgacgacat ttcccaggag ctgaatcaca attccagaga   2340

ctttggccag ctggctgtgg agctcctgga ccagtcctac aagcaggacg aacagctggc   2400

catgaaactg ctgacgtatg agctgaagaa ctggagcaac gccacgtgcc tgcagcttgc   2460

cgtggctgcc aaacaccgcg acttcatcgc gcacacgtgc agccagatgc tgctcaccga   2520

catgtggatg ggccggctcc gcatgcgcaa gaactcaggc ctcaaggtaa ttctgggaat   2580

tctacttcct ccttcaattc tcagcttgga gttcaagaac aaagacgaca tgccctatat   2640

gtctcaggcc caggaaatcc acctccaaga gaaggaggca gaagaaccag agaagcccac   2700

aaaggaaaaa gaggaagagg acatggagct cacagcaatg ttgggacgaa acaacgggga   2760

gtcctccagg aagaaggatg aagaggaagt tcagagcaag caccggttaa tccccctcgg   2820

cagaaaaatc tatgaattct acaatgcacc catcgtgaag ttctggttct acacactggc   2880

gtatatcgga tacctgatgc tcttcaacta tatcgtgtta gtgaagatgg aacgctggcc   2940

gtccacccag gaatggatcg taatctccta tattttcacc ctgggaatag aaaagatgag   3000

agagattctg atgtcagagc cagggaagtt gctacagaaa gtgaaggtat ggctgcagga   3060

gtactggaat gtcacggacc tcatcgccat ccttctgttt tctgtcggaa tgatccttcg   3120

tctccaagac cagcccttca ggagtgacgg gagggtcatc tactgcgtga acatcattta   3180

ctggtatatc cgtctcctag acatcttcgg cgtgaacaag tatttgggcc cgtatgtaat   3240

gatgattgga aaaatgatga tagacatgat gtactttgtc atcattatgc tggtggttct   3300

gatgagcttt ggggtcgcca ggcaagccat cctttttccc aatgaggagc catcatggaa   3360

actggccaag aacatcttct acatgcccta ttggatgatt tatggggaag tgtttgcgga   3420

ccagatagac cctccctgtg gacagaatga gacccgagag gatggtaaaa taatccagct   3480

gcctccctgc aagacaggag cttggatcgt gccggccatc atggcctgct acctcttagt   3540

ggcaaacatc ttgctggtca acctcctcat tgctgtcttt aacaatacat tttttgaagt   3600

aaaatcgata tccaaccaag tctggaagtt tcagaggtat cagctcatca tgactttcca   3660

tgaaaggcca gttctgcccc caccactgat catcttcagc cacatgacca tgatattcca   3720

gcacctgtgc tgccgatgga ggaaacacga gagcgacccg gatgaaaggg actacggcct   3780

gaaactcttc ataaccgatg atgagctcaa gaaagtacat gactttgaag agcaatgcat   3840

agaagaatac ttcagagaaa aggatgatcg gttcaactca tctaatgatg agaggatacg   3900

ggtgacttca gaaagggtgg agaacatgtc tatgcggctg gaggaagtca acgagagaga   3960

gcactccatg aaggcttcac tccagaccgt ggacatccgg ctggcgcagc tggaagacct   4020

tatcgggcgc atggccacgg ccctggagcg cctgacaggt ctggagcggg ccgagtccaa   4080

caaaatccgc tcgaggacct cgtcagactg cacggacgcc gcctacattg tccgtcagag   4140

cagcttcaac agccaggaag ggaacacctt caagctccaa gagagtatag accctgcagg   4200

tgaggagacc atgtccccaa cttctccaac cttaatgccc cgtatgcgaa gccattcttt   4260

ctattcggtc aatatgaaag acaaaggtgg tatagaaaag ttggaaagta tttttaaaga   4320

aaggtccctg agcctacacc gggctactag ttcccactct gtagcaaaag aacccaaagc   4380

tcctgcagcc cctgccaaca ccttggccat tgttcctgat tccagaagac catcatcgtg   4440

tatagacatc tatgtctctg ctatggatga gctccactgt gatatagacc ctctggacaa   4500

ttccgtgaac atccttgggc tgggcgagcc aagcttttca actccagtac cttccacagc   4560

cccttcaagt agtgcctatg caacacttgc acccacagac agacctccaa gccggagcat   4620

tgattttgag gacatcacct ccatggacac tagatctttt tcttcagact acacccacct   4680

cccagaatgc caaaacccct gggactcaga gcctccgatg taccacacca ttgagcgttc   4740

caaaagtagc cgctacctag ccaccacacc ctttcttcta gaagaggctc ccattgtgaa   4800

atctcatagc tttatgtttt ccccctcaag gagctattat gccaactttg gggtgcctgt   4860

aaaaacagca gaatacacaa gtattacaga ctgtattgac acaaggtgtg tcaatgcccc   4920

tcaagcaatt gcggacagag ctgccttccc tggaggtctt ggagacaaag tggaggactt   4980

aacttgctgc catccagagc gagaagcaga actgagtcac cccagctctg acagtgagga   5040

gaatgaggcc aaaggccgca gagccaccat tgcaatatcc tcccaggagg gtgataactc   5100

agagagaacc ctgtccaaca acatcactgt tcccaagata gagcgcgcca acagctactc   5160

ggcagaggag ccaagtgcgc catatgcaca caccaggaag agcttctcca tcagtgacaa   5220

actcgacagg cagcggaaca cagcaagcct gcgaaatccc ttccagagaa gcaagtcctc   5280

caagccggag ggccgagggg acagcctgtc catgaggaga ctgtccagaa catcggcttt   5340

ccaaagcttt gaaagcaagc acaactaaac cttcttaata tccgccacag aaggctcaag   5400

aatccagccc taaaattctc tccaactcca gtttttcccc tttccttgaa tcatacctgc   5460

tttattctta gctgagcaaa acaagcaatg ctttgggagg tgttaactca aaggtgactt   5520

ctgggccaca gatcaagaaa gcatttgatc tgacccagtg ccagacacag gggatttaag   5580

gcatgttcac acttgctggg cagggagggg gaagagaggg agaaggaagg gttagagatg   5640

aatgtgtatc cgcagtcaca gcagaaagcc atgagagcag gggaaacaag gggcttcgag   5700

cacgctccat gccaggaggc atctgttgat ttctgaccat tatcaagagt tgtaggatgc   5760

agggctaaat tgcaaaataa aataaaatag ccagcgtaca caatgagata ttctaaactt   5820

ccattctgtt ttcttttcac attggctcca tcactggtga ctgatgaaga gcatcctctt   5880

tattcagtat aagccggcag caagcagttc tacctaacgt cccacatcct tctcatgcca   5940

acacttctgt aattgatcat tataaagaaa aaacaaggta acagtcatag ttcacctgtc   6000

tcttatctat tcacttctgg tgccacaact gtttatcctt ttttgaagaa aataagggaa   6060

cagaaatgcc tttttgtatt gcaatcgaaa tgaaagaaga gttgatgtta aaaaaacaaa   6120

agtcaagtga tttattatat acagtgggcg ttcaagtcta gtcgagcaag ctcaggagaa   6180

tgtaattaaa taattttata ttttttaatt tattttgtat ctcacctgtc atggatgaat   6240

tcattcactg aatatgtaat attgaactta aaaaaaaaaa aaaaaaaaca gtggacagaa   6300

ctagcctgaa attgccatgt gggatgttct gttctcaccg ttcatgtcgt gtgttgtgct   6360

gctgtgtgac cgtcatcatt tgcatggctc caccacgtcc tcctgaacac ctccaagacg   6420

taactgccaa tttttcacac cactcatcac atgaccattt tgtatatgaa tatatggtta   6480

tatgtggata ttttcatacc tagagttttg ccatctaatc tgagctcagc ataaatttaa   6540

ttggagtttt tcaagggctg gtatcttttc tatggaaatg ttccaaagta ctttttaagg   6600

aagtttcaaa actataaata accttagatt tgactgggag tttggtatca acccaaagcc   6660

atcagttgca agcataccat gaatattttt cttatagaca gagctataaa aaaagataca   6720

gtagaccaaa atagaaagca aataaaccat ataaagagtt ctatagtata tgccacttat   6780

acacatgtat atgcatttat gcagagacac atatttatat ataaaataaa tggacataaa   6840

gagcttt                                                             6847


<210>  2471
<211>  1707
<212>  PRT
<213>  Homo sapiens

<400>  2471


Met Pro Glu Pro Trp Gly Thr Val Tyr Phe Leu Gly Ile Ala Gln Val 
1               5                   10                  15      


Phe Ser Phe Leu Phe Ser Trp Trp Asn Leu Glu Gly Val Met Asn Gln 
            20                  25                  30          


Ala Asp Ala Pro Arg Pro Leu Asn Trp Thr Ile Arg Lys Leu Cys His 
        35                  40                  45              


Ala Ala Phe Leu Pro Ser Val Arg Leu Leu Lys Ala Gln Lys Ser Trp 
    50                  55                  60                  


Ile Glu Arg Ala Phe Tyr Lys Arg Glu Cys Val His Ile Ile Pro Ser 
65                  70                  75                  80  


Thr Lys Asp Pro His Arg Cys Cys Cys Gly Arg Leu Ile Gly Gln His 
                85                  90                  95      


Val Gly Leu Thr Pro Ser Ile Ser Val Leu Gln Asn Glu Lys Asn Glu 
            100                 105                 110         


Ser Arg Leu Ser Arg Asn Asp Ile Gln Ser Glu Lys Trp Ser Ile Ser 
        115                 120                 125             


Lys His Thr Gln Leu Ser Pro Thr Asp Ala Phe Gly Thr Ile Glu Phe 
    130                 135                 140                 


Gln Gly Gly Gly His Ser Asn Lys Ala Met Tyr Val Arg Val Ser Phe 
145                 150                 155                 160 


Asp Thr Lys Pro Asp Leu Leu Leu His Leu Met Thr Lys Glu Trp Gln 
                165                 170                 175     


Leu Glu Leu Pro Lys Leu Leu Ile Ser Val His Gly Gly Leu Gln Asn 
            180                 185                 190         


Phe Glu Leu Gln Pro Lys Leu Lys Gln Val Phe Gly Lys Gly Leu Ile 
        195                 200                 205             


Lys Ala Ala Met Thr Thr Gly Ala Trp Ile Phe Thr Gly Gly Val Asn 
    210                 215                 220                 


Thr Gly Val Ile Arg His Val Gly Asp Ala Leu Lys Asp His Ala Ser 
225                 230                 235                 240 


Lys Ser Arg Gly Lys Ile Cys Thr Ile Gly Ile Ala Pro Trp Gly Ile 
                245                 250                 255     


Val Glu Asn Gln Glu Asp Leu Ile Gly Arg Asp Val Val Arg Pro Tyr 
            260                 265                 270         


Gln Thr Met Ser Asn Pro Met Ser Lys Leu Thr Val Leu Asn Ser Met 
        275                 280                 285             


His Ser His Phe Ile Leu Ala Asp Asn Gly Thr Thr Gly Lys Tyr Gly 
    290                 295                 300                 


Ala Glu Val Lys Leu Arg Arg Gln Leu Glu Lys His Ile Ser Leu Gln 
305                 310                 315                 320 


Lys Ile Asn Thr Arg Ile Gly Gln Gly Val Pro Val Val Ala Leu Ile 
                325                 330                 335     


Val Glu Gly Gly Pro Asn Val Ile Ser Ile Val Leu Glu Tyr Leu Arg 
            340                 345                 350         


Asp Thr Pro Pro Val Pro Val Val Val Cys Asp Gly Ser Gly Arg Ala 
        355                 360                 365             


Ser Asp Ile Leu Ala Phe Gly His Lys Tyr Ser Glu Glu Gly Gly Leu 
    370                 375                 380                 


Ile Asn Glu Ser Leu Arg Asp Gln Leu Leu Val Thr Ile Gln Lys Thr 
385                 390                 395                 400 


Phe Thr Tyr Thr Arg Thr Gln Ala Gln His Leu Phe Ile Ile Leu Met 
                405                 410                 415     


Glu Cys Met Lys Lys Lys Glu Leu Ile Thr Val Phe Arg Met Gly Ser 
            420                 425                 430         


Glu Gly His Gln Asp Ile Asp Leu Ala Ile Leu Thr Ala Leu Leu Lys 
        435                 440                 445             


Gly Ala Asn Ala Ser Ala Pro Asp Gln Leu Ser Leu Ala Leu Ala Trp 
    450                 455                 460                 


Asn Arg Val Asp Ile Ala Arg Ser Gln Ile Phe Ile Tyr Gly Gln Gln 
465                 470                 475                 480 


Trp Pro Val Gly Ser Leu Glu Gln Ala Met Leu Asp Ala Leu Val Leu 
                485                 490                 495     


Asp Arg Val Asp Phe Val Lys Leu Leu Ile Glu Asn Gly Val Ser Met 
            500                 505                 510         


His Arg Phe Leu Thr Ile Ser Arg Leu Glu Glu Leu Tyr Asn Thr Arg 
        515                 520                 525             


His Gly Pro Ser Asn Thr Leu Tyr His Leu Val Arg Asp Val Lys Lys 
    530                 535                 540                 


Gly Asn Leu Pro Pro Asp Tyr Arg Ile Ser Leu Ile Asp Ile Gly Leu 
545                 550                 555                 560 


Val Ile Glu Tyr Leu Met Gly Gly Ala Tyr Arg Cys Asn Tyr Thr Arg 
                565                 570                 575     


Lys Arg Phe Arg Thr Leu Tyr His Asn Leu Phe Gly Pro Lys Arg Pro 
            580                 585                 590         


Lys Ala Leu Lys Leu Leu Gly Met Glu Asp Asp Ile Pro Leu Arg Arg 
        595                 600                 605             


Gly Arg Lys Thr Thr Lys Lys Arg Glu Glu Glu Val Asp Ile Asp Leu 
    610                 615                 620                 


Asp Asp Pro Glu Ile Asn His Phe Pro Phe Pro Phe His Glu Leu Met 
625                 630                 635                 640 


Val Trp Ala Val Leu Met Lys Arg Gln Lys Met Ala Leu Phe Phe Trp 
                645                 650                 655     


Gln His Gly Glu Glu Ala Met Ala Lys Ala Leu Val Ala Cys Lys Leu 
            660                 665                 670         


Cys Lys Ala Met Ala His Glu Ala Ser Glu Asn Asp Met Val Asp Asp 
        675                 680                 685             


Ile Ser Gln Glu Leu Asn His Asn Ser Arg Asp Phe Gly Gln Leu Ala 
    690                 695                 700                 


Val Glu Leu Leu Asp Gln Ser Tyr Lys Gln Asp Glu Gln Leu Ala Met 
705                 710                 715                 720 


Lys Leu Leu Thr Tyr Glu Leu Lys Asn Trp Ser Asn Ala Thr Cys Leu 
                725                 730                 735     


Gln Leu Ala Val Ala Ala Lys His Arg Asp Phe Ile Ala His Thr Cys 
            740                 745                 750         


Ser Gln Met Leu Leu Thr Asp Met Trp Met Gly Arg Leu Arg Met Arg 
        755                 760                 765             


Lys Asn Ser Gly Leu Lys Val Ile Leu Gly Ile Leu Leu Pro Pro Ser 
    770                 775                 780                 


Ile Leu Ser Leu Glu Phe Lys Asn Lys Asp Asp Met Pro Tyr Met Ser 
785                 790                 795                 800 


Gln Ala Gln Glu Ile His Leu Gln Glu Lys Glu Ala Glu Glu Pro Glu 
                805                 810                 815     


Lys Pro Thr Lys Glu Lys Glu Glu Glu Asp Met Glu Leu Thr Ala Met 
            820                 825                 830         


Leu Gly Arg Asn Asn Gly Glu Ser Ser Arg Lys Lys Asp Glu Glu Glu 
        835                 840                 845             


Val Gln Ser Lys His Arg Leu Ile Pro Leu Gly Arg Lys Ile Tyr Glu 
    850                 855                 860                 


Phe Tyr Asn Ala Pro Ile Val Lys Phe Trp Phe Tyr Thr Leu Ala Tyr 
865                 870                 875                 880 


Ile Gly Tyr Leu Met Leu Phe Asn Tyr Ile Val Leu Val Lys Met Glu 
                885                 890                 895     


Arg Trp Pro Ser Thr Gln Glu Trp Ile Val Ile Ser Tyr Ile Phe Thr 
            900                 905                 910         


Leu Gly Ile Glu Lys Met Arg Glu Ile Leu Met Ser Glu Pro Gly Lys 
        915                 920                 925             


Leu Leu Gln Lys Val Lys Val Trp Leu Gln Glu Tyr Trp Asn Val Thr 
    930                 935                 940                 


Asp Leu Ile Ala Ile Leu Leu Phe Ser Val Gly Met Ile Leu Arg Leu 
945                 950                 955                 960 


Gln Asp Gln Pro Phe Arg Ser Asp Gly Arg Val Ile Tyr Cys Val Asn 
                965                 970                 975     


Ile Ile Tyr Trp Tyr Ile Arg Leu Leu Asp Ile Phe Gly Val Asn Lys 
            980                 985                 990         


Tyr Leu Gly Pro Tyr Val Met Met  Ile Gly Lys Met Met  Ile Asp Met 
        995                 1000                 1005             


Met Tyr  Phe Val Ile Ile Met  Leu Val Val Leu Met  Ser Phe Gly 
    1010                 1015                 1020             


Val Ala  Arg Gln Ala Ile Leu  Phe Pro Asn Glu Glu  Pro Ser Trp 
    1025                 1030                 1035             


Lys Leu  Ala Lys Asn Ile Phe  Tyr Met Pro Tyr Trp  Met Ile Tyr 
    1040                 1045                 1050             


Gly Glu  Val Phe Ala Asp Gln  Ile Asp Pro Pro Cys  Gly Gln Asn 
    1055                 1060                 1065             


Glu Thr  Arg Glu Asp Gly Lys  Ile Ile Gln Leu Pro  Pro Cys Lys 
    1070                 1075                 1080             


Thr Gly  Ala Trp Ile Val Pro  Ala Ile Met Ala Cys  Tyr Leu Leu 
    1085                 1090                 1095             


Val Ala  Asn Ile Leu Leu Val  Asn Leu Leu Ile Ala  Val Phe Asn 
    1100                 1105                 1110             


Asn Thr  Phe Phe Glu Val Lys  Ser Ile Ser Asn Gln  Val Trp Lys 
    1115                 1120                 1125             


Phe Gln  Arg Tyr Gln Leu Ile  Met Thr Phe His Glu  Arg Pro Val 
    1130                 1135                 1140             


Leu Pro  Pro Pro Leu Ile Ile  Phe Ser His Met Thr  Met Ile Phe 
    1145                 1150                 1155             


Gln His  Leu Cys Cys Arg Trp  Arg Lys His Glu Ser  Asp Pro Asp 
    1160                 1165                 1170             


Glu Arg  Asp Tyr Gly Leu Lys  Leu Phe Ile Thr Asp  Asp Glu Leu 
    1175                 1180                 1185             


Lys Lys  Val His Asp Phe Glu  Glu Gln Cys Ile Glu  Glu Tyr Phe 
    1190                 1195                 1200             


Arg Glu  Lys Asp Asp Arg Phe  Asn Ser Ser Asn Asp  Glu Arg Ile 
    1205                 1210                 1215             


Arg Val  Thr Ser Glu Arg Val  Glu Asn Met Ser Met  Arg Leu Glu 
    1220                 1225                 1230             


Glu Val  Asn Glu Arg Glu His  Ser Met Lys Ala Ser  Leu Gln Thr 
    1235                 1240                 1245             


Val Asp  Ile Arg Leu Ala Gln  Leu Glu Asp Leu Ile  Gly Arg Met 
    1250                 1255                 1260             


Ala Thr  Ala Leu Glu Arg Leu  Thr Gly Leu Glu Arg  Ala Glu Ser 
    1265                 1270                 1275             


Asn Lys  Ile Arg Ser Arg Thr  Ser Ser Asp Cys Thr  Asp Ala Ala 
    1280                 1285                 1290             


Tyr Ile  Val Arg Gln Ser Ser  Phe Asn Ser Gln Glu  Gly Asn Thr 
    1295                 1300                 1305             


Phe Lys  Leu Gln Glu Ser Ile  Asp Pro Ala Gly Glu  Glu Thr Met 
    1310                 1315                 1320             


Ser Pro  Thr Ser Pro Thr Leu  Met Pro Arg Met Arg  Ser His Ser 
    1325                 1330                 1335             


Phe Tyr  Ser Val Asn Met Lys  Asp Lys Gly Gly Ile  Glu Lys Leu 
    1340                 1345                 1350             


Glu Ser  Ile Phe Lys Glu Arg  Ser Leu Ser Leu His  Arg Ala Thr 
    1355                 1360                 1365             


Ser Ser  His Ser Val Ala Lys  Glu Pro Lys Ala Pro  Ala Ala Pro 
    1370                 1375                 1380             


Ala Asn  Thr Leu Ala Ile Val  Pro Asp Ser Arg Arg  Pro Ser Ser 
    1385                 1390                 1395             


Cys Ile  Asp Ile Tyr Val Ser  Ala Met Asp Glu Leu  His Cys Asp 
    1400                 1405                 1410             


Ile Asp  Pro Leu Asp Asn Ser  Val Asn Ile Leu Gly  Leu Gly Glu 
    1415                 1420                 1425             


Pro Ser  Phe Ser Thr Pro Val  Pro Ser Thr Ala Pro  Ser Ser Ser 
    1430                 1435                 1440             


Ala Tyr  Ala Thr Leu Ala Pro  Thr Asp Arg Pro Pro  Ser Arg Ser 
    1445                 1450                 1455             


Ile Asp  Phe Glu Asp Ile Thr  Ser Met Asp Thr Arg  Ser Phe Ser 
    1460                 1465                 1470             


Ser Asp  Tyr Thr His Leu Pro  Glu Cys Gln Asn Pro  Trp Asp Ser 
    1475                 1480                 1485             


Glu Pro  Pro Met Tyr His Thr  Ile Glu Arg Ser Lys  Ser Ser Arg 
    1490                 1495                 1500             


Tyr Leu  Ala Thr Thr Pro Phe  Leu Leu Glu Glu Ala  Pro Ile Val 
    1505                 1510                 1515             


Lys Ser  His Ser Phe Met Phe  Ser Pro Ser Arg Ser  Tyr Tyr Ala 
    1520                 1525                 1530             


Asn Phe  Gly Val Pro Val Lys  Thr Ala Glu Tyr Thr  Ser Ile Thr 
    1535                 1540                 1545             


Asp Cys  Ile Asp Thr Arg Cys  Val Asn Ala Pro Gln  Ala Ile Ala 
    1550                 1555                 1560             


Asp Arg  Ala Ala Phe Pro Gly  Gly Leu Gly Asp Lys  Val Glu Asp 
    1565                 1570                 1575             


Leu Thr  Cys Cys His Pro Glu  Arg Glu Ala Glu Leu  Ser His Pro 
    1580                 1585                 1590             


Ser Ser  Asp Ser Glu Glu Asn  Glu Ala Lys Gly Arg  Arg Ala Thr 
    1595                 1600                 1605             


Ile Ala  Ile Ser Ser Gln Glu  Gly Asp Asn Ser Glu  Arg Thr Leu 
    1610                 1615                 1620             


Ser Asn  Asn Ile Thr Val Pro  Lys Ile Glu Arg Ala  Asn Ser Tyr 
    1625                 1630                 1635             


Ser Ala  Glu Glu Pro Ser Ala  Pro Tyr Ala His Thr  Arg Lys Ser 
    1640                 1645                 1650             


Phe Ser  Ile Ser Asp Lys Leu  Asp Arg Gln Arg Asn  Thr Ala Ser 
    1655                 1660                 1665             


Leu Arg  Asn Pro Phe Gln Arg  Ser Lys Ser Ser Lys  Pro Glu Gly 
    1670                 1675                 1680             


Arg Gly  Asp Ser Leu Ser Met  Arg Arg Leu Ser Arg  Thr Ser Ala 
    1685                 1690                 1695             


Phe Gln  Ser Phe Glu Ser Lys  His Asn 
    1700                 1705         

<210>  2472
<211>  6109
<212>  DNA
<213>  Homo sapiens

<400>  2472
tccgaccaca ggctgttttg tgcaggctgt ccctcttctt caaaatcgtg catcccctcc     60

ccgaagcagc aggcagtgtg cctccattca gccacatttg gtatgcatga gcacggctgc    120

agagagaggg gaggtggctg ttttaagaag gttcaggggc tcaggcaagg ctacttgact    180

agtcttccaa gttccaggaa gcctctgccc taatggaatt tgcaggtgtg gagatgacca    240

tgggatgcca gagccgtggg ggaccgttta ttttctaggc attgctcagg ttttcagttt    300

cttgttttcc tggtggaatt tggaaggggt catgaatcag gctgatgctc ctcgacccct    360

aaactggacc atccggaagc tgtgccacgc agcctttctt ccatctgtca gacttctgaa    420

ggctcagaaa tcctggatag aaagagcatt ttataaaaga gaatgtgtcc acatcatacc    480

cagcaccaaa gacccccata ggtgttgctg tgggcgtctg ataggccagc atgttggcct    540

cacccccagt atctccgtgc ttcagaatga gaaaaatgaa agtcgcctct cccgaaatga    600

catccagtct gaaaagtggt ccatcagcaa acacactcaa ctcagcccta cggatgcttt    660

tgggaccatt gagttccaag gaggtggcca ttccaacaaa gccatgtatg tgcgagtatc    720

ttttgataca aaacctgatc tcctcttaca cctgatgacc aaggaatggc agttggagct    780

tcccaagctt ctcatctctg tccatggggg cctgcagaac tttgaactcc agccaaaact    840

caagcaagtc tttgggaaag ggctcatcaa agcagcaatg acaactggag cgtggatatt    900

cactggaggg gttaacacag gtgttattcg tcatgttggc gatgccttga aggatcatgc    960

ctctaagtct cgaggaaaga tatgcaccat aggtattgcc ccctggggaa ttgtggaaaa   1020

ccaggaggac ctcattggaa gagatgttgt ccggccatac cagaccatgt ccaatcccat   1080

gagcaagctc actgttctca acagcatgca ttcccacttc attctggctg acaacgggac   1140

cactggaaaa tatggagcag aggtgaaact tcgaagacaa ctggaaaagc atatttcact   1200

ccagaagata aacacaagaa tcggtcaagg tgttcctgtg gtggcactca tagtggaagg   1260

aggacccaat gtgatctcga ttgttttgga gtaccttcga gacacccctc ccgtgccagt   1320

ggttgtctgt gatgggagtg gacgggcatc ggacatcctg gcctttgggc ataaatactc   1380

agaagaaggc ggactgataa atgaatcttt gagggaccag ctgttggtga ctatacagaa   1440

gactttcaca tacactcgaa cccaagctca gcatctgttc atcatcctca tggagtgcat   1500

gaagaagaag gaattgatta cggtatttcg gatgggatca gaaggacacc aggacattga   1560

tttggctatc ctgacagctt tactcaaagg agccaatgcc tcggccccag accaactgag   1620

cttagcttta gcctggaaca gagtcgacat cgctcgcagc cagatcttta tttacgggca   1680

acagtggccg gtgggatctc tggagcaagc catgttggat gccttagttc tggacagagt   1740

ggattttgtg aaattactca tagagaatgg agtaagcatg caccgttttc tcaccatctc   1800

cagactagag gaattgtaca atacgagaca tgggccctca aatacattgt accacttggt   1860

cagggatgtc aaaaagggga acctgccccc agactacaga atcagcctga ttgacatcgg   1920

cctggtgatc gagtacctga tgggcggggc ttatcgctgc aactacacgc gcaagcgctt   1980

ccggaccctc taccacaacc tcttcggccc caagaggccc aaagccttga aactgctggg   2040

aatggaggat gatattccct tgaggcgagg aagaaagaca accaagaaac gtgaagaaga   2100

ggtggacatt gacttggatg atcctgagat caaccacttc cccttccctt tccatgagct   2160

catggtgtgg gctgttctca tgaagcggca gaagatggcc ctgttcttct ggcagcacgg   2220

tgaggaggcc atggccaagg ccctggtggc ctgcaagctc tgcaaagcca tggctcatga   2280

ggcctctgag aacgacatgg ttgacgacat ttcccaggag ctgaatcaca attccagaga   2340

ctttggccag ctggctgtgg agctcctgga ccagtcctac aagcaggacg aacagctggc   2400

catgaaactg ctgacgtatg agctgaagaa ctggagcaac gccacgtgcc tgcagcttgc   2460

cgtggctgcc aaacaccgcg acttcatcgc gcacacgtgc agccagatgc tgctcaccga   2520

catgtggatg ggccggctcc gcatgcgcaa gaactcaggc ctcaaggtaa ttctgggaat   2580

tctacttcct ccttcaattc tcagcttgga gttcaagaac aaagacgaca tgccctatat   2640

gtctcaggcc caggaaatcc acctccaaga gaaggaggca gaagaaccag agaagcccac   2700

aaaggaaaaa gaggaagagg acatggagct cacagcaatg ttgggacgaa acaacgggga   2760

gtcctccagg aagaaggatg aagaggaagt tcagagcaag caccggttaa tccccctcgg   2820

cagaaaaatc tatgaattct acaatgcacc catcgtgaag ttctggttct acacactggc   2880

gtatatcgga tacctgatgc tcttcaacta tatcgtgtta gtgaagatgg aacgctggcc   2940

gtccacccag gaatggatcg taatctccta tattttcacc ctgggaatag aaaagatgag   3000

agagattctg atgtcagagc cagggaagtt gctacagaaa gtgaaggtat ggctgcagga   3060

gtactggaat gtcacggacc tcatcgccat ccttctgttt tctgtcggaa tgatccttcg   3120

tctccaagac cagcccttca ggagtgacgg gagggtcatc tactgcgtga acatcattta   3180

ctggtatatc cgtctcctag acatcttcgg cgtgaacaag tatttgggcc cgtatgtaat   3240

gatgattgga aaaatgatga tagacatgat gtactttgtc atcattatgc tggtggttct   3300

gatgagcttt ggggtcgcca ggcaagccat cctttttccc aatgaggagc catcatggaa   3360

actggccaag aacatcttct acatgcccta ttggatgatt tatggggaag tgtttgcgga   3420

ccagatagac cctccctgtg gacagaatga gacccgagag gatggtaaaa taatccagct   3480

gcctccctgc aagacaggag cttggatcgt gccggccatc atggcctgct acctcttagt   3540

ggcaaacatc ttgctggtca acctcctcat tgctgtcttt aacaatacat tttttgaagt   3600

aaaatcgata tccaaccaag tctggaagtt tcagaggtat cagctcatca tgactttcca   3660

tgaaaggcca gttctgcccc caccactgat catcttcagc cacatgacca tgatattcca   3720

gcacctgtgc tgccgatgga ggaaacacga gagcgacccg gatgaaaggg actacggcct   3780

gaaactcttc ataaccgatg atgagctcaa gaaagtacat gactttgaag agcaatgcat   3840

agaagaatac ttcagagaaa aggatgatcg gttcaactca tctaatgatg agaggatacg   3900

ggtgacttca gaaagggtgg agaacatgtc tatgcggctg gaggaagtca acgagagaga   3960

gcactccatg aaggcttcac tccagaccgt ggacatccgg ctggcgcagc tggaagacct   4020

tatcgggcgc atggccacgg ccctggagcg cctgacaggt ctggagcggg ccgagtccaa   4080

caaaatccgc tcgaggacct cgtcagactg cacggacgcc gcctacattg tccgtcagag   4140

cagcttcaac agccaggaag ggaacacctt caagctccaa gagagtatag accctgcagg   4200

tgaggagacc atgtccccaa cttctccaac cttaatgccc cgtatgcgaa gccattcttt   4260

ctattcggtc aatatgaaag acaaaggtgg tatagaaaag ttggaaagta tttttaaaga   4320

aaggtccctg agcctacacc gggctactag ttcccactct gtagcaaaag aacccaaagc   4380

tcctgcagcc cctgccaaca ccttggccat tgttcctgat tccagaagac catcatcgtg   4440

tatagacatc tatgtctctg ctatggatga gctccactgt gatatagacc ctctggacaa   4500

ttccgtgaac atccttgggc tgggcgagcc aagcttttca actccagtac cttccacagc   4560

cccttcaagt agtgcctatg caacacttgc acccacagac agacctccaa gccggagcat   4620

tgattttgag gacatcacct ccatggacac tagatctttt tcttcagact acacccacct   4680

cccagaatgc caaaacccct gggactcaga gcctccgatg taccacacca ttgagcgttc   4740

caaaagtagc cgctacctag ccaccacacc ctttcttcta gaagaggctc ccattgtgaa   4800

atctcatagc tttatgtttt ccccctcaag gagctattat gccaactttg gggtgcctgt   4860

aaaaacagca gaatacacaa gtattacaga ctgtattgac acaaggtgtg tcaatgcccc   4920

tcaagcaatt gcggacagag ctgccttccc tggaggtctt ggagacaaag tggaggactt   4980

aacttgctgc catccagagc gagaagcaga actgagtcac cccagctctg acagtgagga   5040

gaatgaggcc aaaggccgca gagccaccat tgcaatatcc tcccaggagg gtgataactc   5100

agagagaacc ctgtccaaca acatcactgt tcccaagata gagcgcgcca acagctactc   5160

ggcagaggag ccaagtgcgc catatgcaca caccaggaag agcttctcca tcagtgacaa   5220

actcgacagg cagcggaaca cagcaagcct gcgaaatccc ttccagagaa gcaagtcctc   5280

caagccggag ggccgagggg acagcctgtc catgaggaga ctgtccagaa catcggcttt   5340

ccaaagcttt gaaagcaagc acaactaaac cttcttaata tccgccacag aaggctcaag   5400

aatccagccc taaaattctc tccaactcca gtttttcccc tttccttgaa tcatacctgc   5460

tttattctta gctgagcaaa acaagcaatg ctttgggagg tgttaactca aaggtgactt   5520

ctgggccaca gatcaagaaa gcatttgatc tgacccagtg ccagacacag gggatttaag   5580

gcatgttcac acttgctggg cagggagggg gaagagaggg agaaggaagg gttagagatg   5640

aatgtgtatc cgcagtcaca gcagaaagcc atgagagcag gggaaacaag gggcttcgag   5700

cacgctccat gccaggaggc atctgttgat ttctgaccat tatcaagagt tgtaggatgc   5760

agggctaaat tgcaaaataa aataaaatag ccagcgtaca caatgagata ttctaaactt   5820

ccattctgtt ttcttttcac attggctcca tcactggtga ctgatgaaga gcatcctctt   5880

tattcagtat aagccggcag caagcagttc tacctaacgt cccacatcct tctcatgcca   5940

acacttctgt aattgatcat tataaagaaa aaacaaggta acagtcatag ttcacctgtc   6000

tcttatctat tcacttctgg tgccacaact gtttatcctt ttttgaagaa aataagggaa   6060

cagaaatgcc tttttgtatt gcaatcgaaa tgaaagaaga gttgatgtt               6109


<210>  2473
<211>  1707
<212>  PRT
<213>  Homo sapiens

<400>  2473


Met Pro Glu Pro Trp Gly Thr Val Tyr Phe Leu Gly Ile Ala Gln Val 
1               5                   10                  15      


Phe Ser Phe Leu Phe Ser Trp Trp Asn Leu Glu Gly Val Met Asn Gln 
            20                  25                  30          


Ala Asp Ala Pro Arg Pro Leu Asn Trp Thr Ile Arg Lys Leu Cys His 
        35                  40                  45              


Ala Ala Phe Leu Pro Ser Val Arg Leu Leu Lys Ala Gln Lys Ser Trp 
    50                  55                  60                  


Ile Glu Arg Ala Phe Tyr Lys Arg Glu Cys Val His Ile Ile Pro Ser 
65                  70                  75                  80  


Thr Lys Asp Pro His Arg Cys Cys Cys Gly Arg Leu Ile Gly Gln His 
                85                  90                  95      


Val Gly Leu Thr Pro Ser Ile Ser Val Leu Gln Asn Glu Lys Asn Glu 
            100                 105                 110         


Ser Arg Leu Ser Arg Asn Asp Ile Gln Ser Glu Lys Trp Ser Ile Ser 
        115                 120                 125             


Lys His Thr Gln Leu Ser Pro Thr Asp Ala Phe Gly Thr Ile Glu Phe 
    130                 135                 140                 


Gln Gly Gly Gly His Ser Asn Lys Ala Met Tyr Val Arg Val Ser Phe 
145                 150                 155                 160 


Asp Thr Lys Pro Asp Leu Leu Leu His Leu Met Thr Lys Glu Trp Gln 
                165                 170                 175     


Leu Glu Leu Pro Lys Leu Leu Ile Ser Val His Gly Gly Leu Gln Asn 
            180                 185                 190         


Phe Glu Leu Gln Pro Lys Leu Lys Gln Val Phe Gly Lys Gly Leu Ile 
        195                 200                 205             


Lys Ala Ala Met Thr Thr Gly Ala Trp Ile Phe Thr Gly Gly Val Asn 
    210                 215                 220                 


Thr Gly Val Ile Arg His Val Gly Asp Ala Leu Lys Asp His Ala Ser 
225                 230                 235                 240 


Lys Ser Arg Gly Lys Ile Cys Thr Ile Gly Ile Ala Pro Trp Gly Ile 
                245                 250                 255     


Val Glu Asn Gln Glu Asp Leu Ile Gly Arg Asp Val Val Arg Pro Tyr 
            260                 265                 270         


Gln Thr Met Ser Asn Pro Met Ser Lys Leu Thr Val Leu Asn Ser Met 
        275                 280                 285             


His Ser His Phe Ile Leu Ala Asp Asn Gly Thr Thr Gly Lys Tyr Gly 
    290                 295                 300                 


Ala Glu Val Lys Leu Arg Arg Gln Leu Glu Lys His Ile Ser Leu Gln 
305                 310                 315                 320 


Lys Ile Asn Thr Arg Ile Gly Gln Gly Val Pro Val Val Ala Leu Ile 
                325                 330                 335     


Val Glu Gly Gly Pro Asn Val Ile Ser Ile Val Leu Glu Tyr Leu Arg 
            340                 345                 350         


Asp Thr Pro Pro Val Pro Val Val Val Cys Asp Gly Ser Gly Arg Ala 
        355                 360                 365             


Ser Asp Ile Leu Ala Phe Gly His Lys Tyr Ser Glu Glu Gly Gly Leu 
    370                 375                 380                 


Ile Asn Glu Ser Leu Arg Asp Gln Leu Leu Val Thr Ile Gln Lys Thr 
385                 390                 395                 400 


Phe Thr Tyr Thr Arg Thr Gln Ala Gln His Leu Phe Ile Ile Leu Met 
                405                 410                 415     


Glu Cys Met Lys Lys Lys Glu Leu Ile Thr Val Phe Arg Met Gly Ser 
            420                 425                 430         


Glu Gly His Gln Asp Ile Asp Leu Ala Ile Leu Thr Ala Leu Leu Lys 
        435                 440                 445             


Gly Ala Asn Ala Ser Ala Pro Asp Gln Leu Ser Leu Ala Leu Ala Trp 
    450                 455                 460                 


Asn Arg Val Asp Ile Ala Arg Ser Gln Ile Phe Ile Tyr Gly Gln Gln 
465                 470                 475                 480 


Trp Pro Val Gly Ser Leu Glu Gln Ala Met Leu Asp Ala Leu Val Leu 
                485                 490                 495     


Asp Arg Val Asp Phe Val Lys Leu Leu Ile Glu Asn Gly Val Ser Met 
            500                 505                 510         


His Arg Phe Leu Thr Ile Ser Arg Leu Glu Glu Leu Tyr Asn Thr Arg 
        515                 520                 525             


His Gly Pro Ser Asn Thr Leu Tyr His Leu Val Arg Asp Val Lys Lys 
    530                 535                 540                 


Gly Asn Leu Pro Pro Asp Tyr Arg Ile Ser Leu Ile Asp Ile Gly Leu 
545                 550                 555                 560 


Val Ile Glu Tyr Leu Met Gly Gly Ala Tyr Arg Cys Asn Tyr Thr Arg 
                565                 570                 575     


Lys Arg Phe Arg Thr Leu Tyr His Asn Leu Phe Gly Pro Lys Arg Pro 
            580                 585                 590         


Lys Ala Leu Lys Leu Leu Gly Met Glu Asp Asp Ile Pro Leu Arg Arg 
        595                 600                 605             


Gly Arg Lys Thr Thr Lys Lys Arg Glu Glu Glu Val Asp Ile Asp Leu 
    610                 615                 620                 


Asp Asp Pro Glu Ile Asn His Phe Pro Phe Pro Phe His Glu Leu Met 
625                 630                 635                 640 


Val Trp Ala Val Leu Met Lys Arg Gln Lys Met Ala Leu Phe Phe Trp 
                645                 650                 655     


Gln His Gly Glu Glu Ala Met Ala Lys Ala Leu Val Ala Cys Lys Leu 
            660                 665                 670         


Cys Lys Ala Met Ala His Glu Ala Ser Glu Asn Asp Met Val Asp Asp 
        675                 680                 685             


Ile Ser Gln Glu Leu Asn His Asn Ser Arg Asp Phe Gly Gln Leu Ala 
    690                 695                 700                 


Val Glu Leu Leu Asp Gln Ser Tyr Lys Gln Asp Glu Gln Leu Ala Met 
705                 710                 715                 720 


Lys Leu Leu Thr Tyr Glu Leu Lys Asn Trp Ser Asn Ala Thr Cys Leu 
                725                 730                 735     


Gln Leu Ala Val Ala Ala Lys His Arg Asp Phe Ile Ala His Thr Cys 
            740                 745                 750         


Ser Gln Met Leu Leu Thr Asp Met Trp Met Gly Arg Leu Arg Met Arg 
        755                 760                 765             


Lys Asn Ser Gly Leu Lys Val Ile Leu Gly Ile Leu Leu Pro Pro Ser 
    770                 775                 780                 


Ile Leu Ser Leu Glu Phe Lys Asn Lys Asp Asp Met Pro Tyr Met Ser 
785                 790                 795                 800 


Gln Ala Gln Glu Ile His Leu Gln Glu Lys Glu Ala Glu Glu Pro Glu 
                805                 810                 815     


Lys Pro Thr Lys Glu Lys Glu Glu Glu Asp Met Glu Leu Thr Ala Met 
            820                 825                 830         


Leu Gly Arg Asn Asn Gly Glu Ser Ser Arg Lys Lys Asp Glu Glu Glu 
        835                 840                 845             


Val Gln Ser Lys His Arg Leu Ile Pro Leu Gly Arg Lys Ile Tyr Glu 
    850                 855                 860                 


Phe Tyr Asn Ala Pro Ile Val Lys Phe Trp Phe Tyr Thr Leu Ala Tyr 
865                 870                 875                 880 


Ile Gly Tyr Leu Met Leu Phe Asn Tyr Ile Val Leu Val Lys Met Glu 
                885                 890                 895     


Arg Trp Pro Ser Thr Gln Glu Trp Ile Val Ile Ser Tyr Ile Phe Thr 
            900                 905                 910         


Leu Gly Ile Glu Lys Met Arg Glu Ile Leu Met Ser Glu Pro Gly Lys 
        915                 920                 925             


Leu Leu Gln Lys Val Lys Val Trp Leu Gln Glu Tyr Trp Asn Val Thr 
    930                 935                 940                 


Asp Leu Ile Ala Ile Leu Leu Phe Ser Val Gly Met Ile Leu Arg Leu 
945                 950                 955                 960 


Gln Asp Gln Pro Phe Arg Ser Asp Gly Arg Val Ile Tyr Cys Val Asn 
                965                 970                 975     


Ile Ile Tyr Trp Tyr Ile Arg Leu Leu Asp Ile Phe Gly Val Asn Lys 
            980                 985                 990         


Tyr Leu Gly Pro Tyr Val Met Met  Ile Gly Lys Met Met  Ile Asp Met 
        995                 1000                 1005             


Met Tyr  Phe Val Ile Ile Met  Leu Val Val Leu Met  Ser Phe Gly 
    1010                 1015                 1020             


Val Ala  Arg Gln Ala Ile Leu  Phe Pro Asn Glu Glu  Pro Ser Trp 
    1025                 1030                 1035             


Lys Leu  Ala Lys Asn Ile Phe  Tyr Met Pro Tyr Trp  Met Ile Tyr 
    1040                 1045                 1050             


Gly Glu  Val Phe Ala Asp Gln  Ile Asp Pro Pro Cys  Gly Gln Asn 
    1055                 1060                 1065             


Glu Thr  Arg Glu Asp Gly Lys  Ile Ile Gln Leu Pro  Pro Cys Lys 
    1070                 1075                 1080             


Thr Gly  Ala Trp Ile Val Pro  Ala Ile Met Ala Cys  Tyr Leu Leu 
    1085                 1090                 1095             


Val Ala  Asn Ile Leu Leu Val  Asn Leu Leu Ile Ala  Val Phe Asn 
    1100                 1105                 1110             


Asn Thr  Phe Phe Glu Val Lys  Ser Ile Ser Asn Gln  Val Trp Lys 
    1115                 1120                 1125             


Phe Gln  Arg Tyr Gln Leu Ile  Met Thr Phe His Glu  Arg Pro Val 
    1130                 1135                 1140             


Leu Pro  Pro Pro Leu Ile Ile  Phe Ser His Met Thr  Met Ile Phe 
    1145                 1150                 1155             


Gln His  Leu Cys Cys Arg Trp  Arg Lys His Glu Ser  Asp Pro Asp 
    1160                 1165                 1170             


Glu Arg  Asp Tyr Gly Leu Lys  Leu Phe Ile Thr Asp  Asp Glu Leu 
    1175                 1180                 1185             


Lys Lys  Val His Asp Phe Glu  Glu Gln Cys Ile Glu  Glu Tyr Phe 
    1190                 1195                 1200             


Arg Glu  Lys Asp Asp Arg Phe  Asn Ser Ser Asn Asp  Glu Arg Ile 
    1205                 1210                 1215             


Arg Val  Thr Ser Glu Arg Val  Glu Asn Met Ser Met  Arg Leu Glu 
    1220                 1225                 1230             


Glu Val  Asn Glu Arg Glu His  Ser Met Lys Ala Ser  Leu Gln Thr 
    1235                 1240                 1245             


Val Asp  Ile Arg Leu Ala Gln  Leu Glu Asp Leu Ile  Gly Arg Met 
    1250                 1255                 1260             


Ala Thr  Ala Leu Glu Arg Leu  Thr Gly Leu Glu Arg  Ala Glu Ser 
    1265                 1270                 1275             


Asn Lys  Ile Arg Ser Arg Thr  Ser Ser Asp Cys Thr  Asp Ala Ala 
    1280                 1285                 1290             


Tyr Ile  Val Arg Gln Ser Ser  Phe Asn Ser Gln Glu  Gly Asn Thr 
    1295                 1300                 1305             


Phe Lys  Leu Gln Glu Ser Ile  Asp Pro Ala Gly Glu  Glu Thr Met 
    1310                 1315                 1320             


Ser Pro  Thr Ser Pro Thr Leu  Met Pro Arg Met Arg  Ser His Ser 
    1325                 1330                 1335             


Phe Tyr  Ser Val Asn Met Lys  Asp Lys Gly Gly Ile  Glu Lys Leu 
    1340                 1345                 1350             


Glu Ser  Ile Phe Lys Glu Arg  Ser Leu Ser Leu His  Arg Ala Thr 
    1355                 1360                 1365             


Ser Ser  His Ser Val Ala Lys  Glu Pro Lys Ala Pro  Ala Ala Pro 
    1370                 1375                 1380             


Ala Asn  Thr Leu Ala Ile Val  Pro Asp Ser Arg Arg  Pro Ser Ser 
    1385                 1390                 1395             


Cys Ile  Asp Ile Tyr Val Ser  Ala Met Asp Glu Leu  His Cys Asp 
    1400                 1405                 1410             


Ile Asp  Pro Leu Asp Asn Ser  Val Asn Ile Leu Gly  Leu Gly Glu 
    1415                 1420                 1425             


Pro Ser  Phe Ser Thr Pro Val  Pro Ser Thr Ala Pro  Ser Ser Ser 
    1430                 1435                 1440             


Ala Tyr  Ala Thr Leu Ala Pro  Thr Asp Arg Pro Pro  Ser Arg Ser 
    1445                 1450                 1455             


Ile Asp  Phe Glu Asp Ile Thr  Ser Met Asp Thr Arg  Ser Phe Ser 
    1460                 1465                 1470             


Ser Asp  Tyr Thr His Leu Pro  Glu Cys Gln Asn Pro  Trp Asp Ser 
    1475                 1480                 1485             


Glu Pro  Pro Met Tyr His Thr  Ile Glu Arg Ser Lys  Ser Ser Arg 
    1490                 1495                 1500             


Tyr Leu  Ala Thr Thr Pro Phe  Leu Leu Glu Glu Ala  Pro Ile Val 
    1505                 1510                 1515             


Lys Ser  His Ser Phe Met Phe  Ser Pro Ser Arg Ser  Tyr Tyr Ala 
    1520                 1525                 1530             


Asn Phe  Gly Val Pro Val Lys  Thr Ala Glu Tyr Thr  Ser Ile Thr 
    1535                 1540                 1545             


Asp Cys  Ile Asp Thr Arg Cys  Val Asn Ala Pro Gln  Ala Ile Ala 
    1550                 1555                 1560             


Asp Arg  Ala Ala Phe Pro Gly  Gly Leu Gly Asp Lys  Val Glu Asp 
    1565                 1570                 1575             


Leu Thr  Cys Cys His Pro Glu  Arg Glu Ala Glu Leu  Ser His Pro 
    1580                 1585                 1590             


Ser Ser  Asp Ser Glu Glu Asn  Glu Ala Lys Gly Arg  Arg Ala Thr 
    1595                 1600                 1605             


Ile Ala  Ile Ser Ser Gln Glu  Gly Asp Asn Ser Glu  Arg Thr Leu 
    1610                 1615                 1620             


Ser Asn  Asn Ile Thr Val Pro  Lys Ile Glu Arg Ala  Asn Ser Tyr 
    1625                 1630                 1635             


Ser Ala  Glu Glu Pro Ser Ala  Pro Tyr Ala His Thr  Arg Lys Ser 
    1640                 1645                 1650             


Phe Ser  Ile Ser Asp Lys Leu  Asp Arg Gln Arg Asn  Thr Ala Ser 
    1655                 1660                 1665             


Leu Arg  Asn Pro Phe Gln Arg  Ser Lys Ser Ser Lys  Pro Glu Gly 
    1670                 1675                 1680             


Arg Gly  Asp Ser Leu Ser Met  Arg Arg Leu Ser Arg  Thr Ser Ala 
    1685                 1690                 1695             


Phe Gln  Ser Phe Glu Ser Lys  His Asn 
    1700                 1705         

<210>  2474
<211>  2231
<212>  DNA
<213>  Homo sapiens

<400>  2474
tagtgaggct aatcccgaag cagcacattc caaggggcta atctgcccaa gttcattgct     60

tacttgaaac gtctcttggg ggaagagccg aacaagtgac tttttttttc cagtgggcgg    120

tcataagagc attattaacg gaatgaccag ccctagctgc agcaaaatga aagcaacagg    180

agctgctccg gggactgctt ttgccagtac ccagaatcag tgctcaggct cagaaatcct    240

ggatagaaag agcattttat aaaagagaat gtgtccacat catacccagc accaaagacc    300

cccataggtg ttgctgtggg cgtctgatag gccagcatgt tggcctcacc cccagtatct    360

ccgtgcttca gaatgagaaa aatgaaagtc gcctctcccg aaatgacatc cagtctgaaa    420

agtggtccat cagcaaacac actcaactca gccctacgga tgcttttggg accattgagt    480

tccaaggagg tggccattcc aacaaagcca tgtatgtgcg agtatctttt gatacaaaac    540

ctgatctcct cttacacctg atgaccaagg aatggcagtt ggagcttccc aagcttctca    600

tctctgtcca tgggggcctg cagaactttg aactccagcc aaaactcaag caagtctttg    660

ggaaagggct catcaaagca gcaatgacaa ctggagcgtg gatattcact ggaggggtta    720

acacaggtgt tattcgtcat gttggcgatg ccttgaagga tcatgcctct aagtctcgag    780

gaaagatatg caccataggt attgccccct ggggaattgt ggaaaaccag gaggacctca    840

ttggaagaga tgttgtccgg ccataccaga ccatgtccaa tcccatgagc aagctcactg    900

ttctcaacag catgcattcc cacttcattc tggctgacaa cgggaccact ggaaaatatg    960

gagcagaggt gaaacttcga agacaactgg aaaagcatat ttcactccag aagataaaca   1020

caagaatcgg tcaaggtgtt cctgtggtgg cactcatagt ggaaggagga cccaatgtga   1080

tctcgattgt tttggagtac cttcgagaca cccctcccgt gccagtggtt gtctgtgatg   1140

ggagtggacg ggcatcggac atcctggcct ttgggcataa atactcagaa gaaggcggac   1200

tgataaatga atctttgagg gaccagctgt tggtgactat acagaagact ttcacataca   1260

ctcgaaccca agctcagcat ctgttcatca tcctcatgga gtgcatgaag aagaaggaat   1320

tggtaggtaa ttccgcatgg gtggccagct gtctccacat tttcagtcat tttcttgaat   1380

cacacaacat tttctcaaat catgcaacat tctctctttc tggccgagct tacagctctc   1440

ctcaggctcc attggctcca gtagcttcct ctcctaagta actaagacac tgcttttact   1500

gccttcgagt taataaggtg tgtgcagcag agttttagca tcatttcctt ttggagctca   1560

tccaaacgct ctgactgcct caacaaaatg agttgaagtg ataaaattgg tcccctcctg   1620

gagaacgctt cagcttgatc ttcttaggtt tcggatttca ttttgcttgg aagtcatgaa   1680

ccactgaggt gctttctgtc aaatagcttt aatgacaaag ggtccaggct gttacactaa   1740

tctgtacagg tagaaaacgg agaaacataa gaaatcctgg aggaatctaa aatcagagca   1800

aaatgtgttt ctaaaatcag agcaaaatgt cttacaaatg tggtatgatc agagaccctg   1860

ctagggtgaa caaaatcatg tgattttgtt ctctgcttac tcaaacattt aacaagaact   1920

tgctatctgc caagcaggga gcaagatctt tatgcatata aactcatatg acctttgcaa   1980

ctgtcctgat gagagaggta caattattac cctcatctta cagatgagga aacccggctc   2040

atttgattag taaatgagga gctaagactc aaaaccagtg atgtttaacc tctgtatgga   2100

gtatttttat tcagaaagtg tctcactgaa gccaatgcag tggatcaccc actctgggta   2160

gatgccccca ggcctcagcc agagagacta ttctcaaagg tcagttaaac ccaactgctg   2220

agagagatag c                                                        2231


<210>  2475
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  2475


Met Tyr Val Arg Val Ser Phe Asp Thr Lys Pro Asp Leu Leu Leu His 
1               5                   10                  15      


Leu Met Thr Lys Glu Trp Gln Leu Glu Leu Pro Lys Leu Leu Ile Ser 
            20                  25                  30          


Val His Gly Gly Leu Gln Asn Phe Glu Leu Gln Pro Lys Leu Lys Gln 
        35                  40                  45              


Val Phe Gly Lys Gly Leu Ile Lys Ala Ala Met Thr Thr Gly Ala Trp 
    50                  55                  60                  


Ile Phe Thr Gly Gly Val Asn Thr Gly Val Ile Arg His Val Gly Asp 
65                  70                  75                  80  


Ala Leu Lys Asp His Ala Ser Lys Ser Arg Gly Lys Ile Cys Thr Ile 
                85                  90                  95      


Gly Ile Ala Pro Trp Gly Ile Val Glu Asn Gln Glu Asp Leu Ile Gly 
            100                 105                 110         


Arg Asp Val Val Arg Pro Tyr Gln Thr Met Ser Asn Pro Met Ser Lys 
        115                 120                 125             


Leu Thr Val Leu Asn Ser Met His Ser His Phe Ile Leu Ala Asp Asn 
    130                 135                 140                 


Gly Thr Thr Gly Lys Tyr Gly Ala Glu Val Lys Leu Arg Arg Gln Leu 
145                 150                 155                 160 


Glu Lys His Ile Ser Leu Gln Lys Ile Asn Thr Arg Ile Gly Gln Gly 
                165                 170                 175     


Val Pro Val Val Ala Leu Ile Val Glu Gly Gly Pro Asn Val Ile Ser 
            180                 185                 190         


Ile Val Leu Glu Tyr Leu Arg Asp Thr Pro Pro Val Pro Val Val Val 
        195                 200                 205             


Cys Asp Gly Ser Gly Arg Ala Ser Asp Ile Leu Ala Phe Gly His Lys 
    210                 215                 220                 


Tyr Ser Glu Glu Gly Gly Leu Ile Asn Glu Ser Leu Arg Asp Gln Leu 
225                 230                 235                 240 


Leu Val Thr Ile Gln Lys Thr Phe Thr Tyr Thr Arg Thr Gln Ala Gln 
                245                 250                 255     


His Leu Phe Ile Ile Leu Met Glu Cys Met Lys Lys Lys Glu Leu Val 
            260                 265                 270         


Gly Asn Ser Ala Trp Val Ala Ser Cys Leu His Ile Phe Ser His Phe 
        275                 280                 285             


Leu Glu Ser His Asn Ile Phe Ser Asn His Ala Thr Phe Ser Leu Ser 
    290                 295                 300                 


Gly Arg Ala Tyr Ser Ser Pro Gln Ala Pro Leu Ala Pro Val Ala Ser 
305                 310                 315                 320 


Ser Pro Lys 
            

<210>  2476
<211>  1442
<212>  DNA
<213>  Homo sapiens

<400>  2476
tagtgaggct aatcccgaag cagcacattc caaggggcta atctgcccaa gttcattgct     60

tacttgaaac gtctcttggg ggaagagccg aacaagtgac tttttttttc cagtgggcgg    120

tcataagagc attattaacg gaatgaccag ccctagctgc agcaaaatga aagcaacagg    180

agctgctccg gggactgctt ttgccagtac ccagaatcag tgctcaggct cagaaatcct    240

ggatagaaag agcattttat aaaagagaat gtgtccacat catacccagc accaaagacc    300

cccataggtg ttgctgtggg cgtctgatag gccagcatgt tggcctcacc cccagtatct    360

ccgtgcttca gaatgagaaa aatgaaagtc gcctctcccg aaatgacatc cagtctgaaa    420

agtggtccat cagcaaacac actcaactca gccctacgga tgcttttggg accattgagt    480

tccaaggagg tggccattcc aacaaagcca tgtatgtgcg agtatctttt gatacaaaac    540

ctgatctcct cttacacctg atgaccaagg aatggcagtt ggagcttccc aagcttctca    600

tctctgtcca tgggggcctg cagaactttg aactccagcc aaaactcaag caagtctttg    660

ggaaagggct catcaaagca gcaatgacaa ctggagcgtg gatattcact ggaggggtta    720

acacaggtgt tattcgtcat gttggcgatg ccttgaagga tcatgcctct aagtctcgag    780

gaaagatatg caccataggt attgccccct ggggaattgt ggaaaaccag gaggacctca    840

ttggaagaga tgttgtccgg ccataccaga ccatgtccaa tcccatgagc aagctcactg    900

ttctcaacag catgcattcc cacttcattc tggctgacaa cgggaccact ggaaaatatg    960

gagcagaggt gaaacttcga agacaactgg aaaagcatat ttcactccag aagataaaca   1020

caagaatcgg tcaaggtgtt cctgtggtgg cactcatagt ggaaggagga cccaatgtga   1080

tctcgattgt tttggagtac cttcgagaca cccctcccgt gccagtggtt gtctgtgatg   1140

ggagtggacg ggcatcggac atcctggcct ttgggcataa atactcagaa gaaggcgggt   1200

aggtaacttt ccaggcccca tggaagaacc ctaaagcctg tttggaaacg agggtatgag   1260

tggattatgt tttcagtagc tcaaccaaga cctcaaatca aaacaagcta tgaacaaatt   1320

gtctaaaaaa tgtctgtcat gggagggctg tggtgaagaa cagagaaaca tattctaaat   1380

gtcctgtgaa gtgggaaatt ctatgaaagc tacacggata ataaaaaggg tgaggaaaag   1440

ag                                                                  1442


<210>  2477
<211>  230
<212>  PRT
<213>  Homo sapiens

<400>  2477


Met Tyr Val Arg Val Ser Phe Asp Thr Lys Pro Asp Leu Leu Leu His 
1               5                   10                  15      


Leu Met Thr Lys Glu Trp Gln Leu Glu Leu Pro Lys Leu Leu Ile Ser 
            20                  25                  30          


Val His Gly Gly Leu Gln Asn Phe Glu Leu Gln Pro Lys Leu Lys Gln 
        35                  40                  45              


Val Phe Gly Lys Gly Leu Ile Lys Ala Ala Met Thr Thr Gly Ala Trp 
    50                  55                  60                  


Ile Phe Thr Gly Gly Val Asn Thr Gly Val Ile Arg His Val Gly Asp 
65                  70                  75                  80  


Ala Leu Lys Asp His Ala Ser Lys Ser Arg Gly Lys Ile Cys Thr Ile 
                85                  90                  95      


Gly Ile Ala Pro Trp Gly Ile Val Glu Asn Gln Glu Asp Leu Ile Gly 
            100                 105                 110         


Arg Asp Val Val Arg Pro Tyr Gln Thr Met Ser Asn Pro Met Ser Lys 
        115                 120                 125             


Leu Thr Val Leu Asn Ser Met His Ser His Phe Ile Leu Ala Asp Asn 
    130                 135                 140                 


Gly Thr Thr Gly Lys Tyr Gly Ala Glu Val Lys Leu Arg Arg Gln Leu 
145                 150                 155                 160 


Glu Lys His Ile Ser Leu Gln Lys Ile Asn Thr Arg Ile Gly Gln Gly 
                165                 170                 175     


Val Pro Val Val Ala Leu Ile Val Glu Gly Gly Pro Asn Val Ile Ser 
            180                 185                 190         


Ile Val Leu Glu Tyr Leu Arg Asp Thr Pro Pro Val Pro Val Val Val 
        195                 200                 205             


Cys Asp Gly Ser Gly Arg Ala Ser Asp Ile Leu Ala Phe Gly His Lys 
    210                 215                 220                 


Tyr Ser Glu Glu Gly Gly 
225                 230 

<210>  2478
<211>  1510
<212>  DNA
<213>  Homo sapiens

<400>  2478
tagtgaggct aatcccgaag cagcacattc caaggggcta atctgcccaa gttcattgct     60

tacttgaaac gtctcttggg ggaagagccg aacaagtgac tttttttttc cagtgggcgg    120

tcataagagc attattaacg gaatgaccag ccctagctgc agcaaaatga aagcaacagg    180

agctgctccg gggactgctt ttgccagtac ccagaatcag tgctcaggct cagaaatcct    240

ggatagaaag agcattttat aaaagagaat gtgtccacat catacccagc accaaagacc    300

cccataggtg ttgctgtggg cgtctgatag gccagcatgt tggcctcacc cccagtatct    360

ccgtgcttca gaatgagaaa aatgaaagtc gcctctcccg aaatgacatc cagtctgaaa    420

agtggtccat cagcaaacac actcaactca gccctacgga tgcttttggg accattgagt    480

tccaaggagg tggccattcc aacaaagcca tgtatgtgcg agtatctttt gatacaaaac    540

ctgatctcct cttacacctg atgaccaagg aatggcagtt ggagcttccc aagcttctca    600

tctctgtcca tgggggcctg cagaactttg aactccagcc aaaactcaag caagtctttg    660

ggaaagggct catcaaagca gcaatgacaa ctggagcgtg gatattcact ggaggggtta    720

acacaggtgt tattcgtcat gttggcgatg ccttgaagga tcatgcctct aagtctcgag    780

gaaagatatg caccataggt attgccccct ggggaattgt ggaaaaccag gaggacctca    840

ttggaagaga tgttgtccgg ccataccaga ccatgtccaa tcccatgagc aagctcactg    900

ttctcaacag catgcattcc cacttcattc tggctgacaa cgggaccact ggaaaatatg    960

gagcagaggt gaaacttcga agacaactgg aaaagcatat ttcactccag aagataaaca   1020

caagatgcct gccgtttttc tctcttgact cccgcttgtt ttattcattt tggggtagtt   1080

gccagttaga ctcagttgga atcggtcaag gtgttcctgt ggtggcactc atagtggaag   1140

gaggacccaa tgtgatctcg attgttttgg agtaccttcg agacacccct cccgtgccag   1200

tggttgtctg tgatgggagt ggacgggcat cggacatcct ggcctttggg cataaatact   1260

cagaagaagg cgggtaggta actttccagg ccccatggaa gaaccctaaa gcctgtttgg   1320

aaacgagggt atgagtggat tatgttttca gtagctcaac caagacctca aatcaaaaca   1380

agctatgaac aaattgtcta aaaaatgtct gtcatgggag ggctgtggtg aagaacagag   1440

aaacatattc taaatgtcct gtgaagtggg aaattctatg aaagctacac ggataataaa   1500

aagggtgagg                                                          1510


<210>  2479
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  2479


Met Tyr Val Arg Val Ser Phe Asp Thr Lys Pro Asp Leu Leu Leu His 
1               5                   10                  15      


Leu Met Thr Lys Glu Trp Gln Leu Glu Leu Pro Lys Leu Leu Ile Ser 
            20                  25                  30          


Val His Gly Gly Leu Gln Asn Phe Glu Leu Gln Pro Lys Leu Lys Gln 
        35                  40                  45              


Val Phe Gly Lys Gly Leu Ile Lys Ala Ala Met Thr Thr Gly Ala Trp 
    50                  55                  60                  


Ile Phe Thr Gly Gly Val Asn Thr Gly Val Ile Arg His Val Gly Asp 
65                  70                  75                  80  


Ala Leu Lys Asp His Ala Ser Lys Ser Arg Gly Lys Ile Cys Thr Ile 
                85                  90                  95      


Gly Ile Ala Pro Trp Gly Ile Val Glu Asn Gln Glu Asp Leu Ile Gly 
            100                 105                 110         


Arg Asp Val Val Arg Pro Tyr Gln Thr Met Ser Asn Pro Met Ser Lys 
        115                 120                 125             


Leu Thr Val Leu Asn Ser Met His Ser His Phe Ile Leu Ala Asp Asn 
    130                 135                 140                 


Gly Thr Thr Gly Lys Tyr Gly Ala Glu Val Lys Leu Arg Arg Gln Leu 
145                 150                 155                 160 


Glu Lys His Ile Ser Leu Gln Lys Ile Asn Thr Arg Cys Leu Pro Phe 
                165                 170                 175     


Phe Ser Leu Asp Ser Arg Leu Phe Tyr Ser Phe Trp Gly Ser Cys Gln 
            180                 185                 190         


Leu Asp Ser Val Gly Ile Gly Gln Gly Val Pro Val Val Ala Leu Ile 
        195                 200                 205             


Val Glu Gly Gly Pro Asn Val Ile Ser Ile Val Leu Glu Tyr Leu Arg 
    210                 215                 220                 


Asp Thr Pro Pro Val Pro Val Val Val Cys Asp Gly Ser Gly Arg Ala 
225                 230                 235                 240 


Ser Asp Ile Leu Ala Phe Gly His Lys Tyr Ser Glu Glu Gly Gly 
                245                 250                 255 

<210>  2480
<211>  1931
<212>  DNA
<213>  Homo sapiens

<400>  2480
tagtgaggct aatcccgaag cagcacattc caaggggcta atctgcccaa gttcattgct     60

tacttgaaac gtctcttggg ggaagagccg aacaagtgac tttttttttc cagtgggcgg    120

tcataagagc attattaacg gaatgaccag ccctagctgc agcaaaatga aagcaacagg    180

agctgctccg gggactgctt ttgccagtac ccagaatcag tgctcaggct cagaaatcct    240

ggatagaaag agcattttat aaaagagaat gtgtccacat catacccagc accaaagacc    300

cccataggtg ttgctgtggg cgtctgatag gccagcatgt tggcctcacc cccagtatct    360

ccgtgcttca gaatgagaaa aatgaaagtc gcctctcccg aaatgacatc cagtctgaaa    420

agtggtccat cagcaaacac actcaactca gccctacgga tgcttttggg accattgagt    480

tccaaggagg tggccattcc aacaaagcca tgtatgtgcg agtatctttt gatacaaaac    540

ctgatctcct cttacacctg atgaccaagg aatggcagtt ggagcttccc aagcttctca    600

tctctgtcca tgggggcctg cagaactttg aactccagcc aaaactcaag caagtctttg    660

ggaaagggct catcaaagca gcaatgacaa ctggagcgtg gatattcact ggaggggtta    720

acacaggtgt tattcgtcat gttggcgatg ccttgaagga tcatgcctct aagtctcgag    780

gaaagatatg caccataggt attgccccct ggggaattgt ggaaaaccag gaggacctca    840

ttggaagaga tgttgtccgg ccataccaga ccatgtccaa tcccatgagc aagctcactg    900

ttctcaacag catgcattcc cacttcattc tggctgacaa cgggaccact ggaaaatatg    960

gagcagaggt gaaacttcga agacaactgg aaaagcatat ttcactccag aagataaaca   1020

caagttttca tagttacaaa acagctcatg tggaccttca ggataaaaga caggtgaaga   1080

ctgccttaga gcaagcagag tggcagccgg gaagaggaat gtttgatcat gataatctca   1140

tgcaaagtac ataaaggggg gggccatgtg atctctcccc tccatggtac cctctgctcc   1200

tttgttttct acctgcatat ggcttttttg ttcattggct taccttcctc acatggttgg   1260

tctggaggac caccactaac agaggcttca ttccccaagt atgcatgccc tggaagccca   1320

tctcccagtt actggccttg ggctcaggat ctccacttca atcccaggaa agcaaatctg   1380

gctcactgca ggtctgacat ccatgtaagt ccagccagct ttgaaaaaag tcaagcaggg   1440

ctgcgccttc tatgcagtgg atgggtctgt tctctgacag gggagagggg atagggcgga   1500

caccatgaga gttttcagta cacatgccac agtgacctct ttggccagct taaaggattt   1560

cccattcaat ctactcatcc actgcccagc ttctgtcctt tgtcctccga ttactagata   1620

gaaaagcaaa gcaagaaggc aatgccccaa aagaaggcca gtcgatgggc attaatacag   1680

gattgctgtg aaaatgcctc gagcactgag aatgcacaaa atagatttgt ttagctgtat   1740

tgaaaacaaa cagaaaaaaa tacagtttgc catattaatt taatatattc tgcattctca   1800

gtccctagga aaagatacac tatgcaccat cagttttcaa ttttttatca ctgtgtgagg   1860

gaggcattct aattaatcca aactctatat tttcagtgtc ttgacatccc catatctcca   1920

gccaaatttg c                                                        1931


<210>  2481
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  2481


Met Tyr Val Arg Val Ser Phe Asp Thr Lys Pro Asp Leu Leu Leu His 
1               5                   10                  15      


Leu Met Thr Lys Glu Trp Gln Leu Glu Leu Pro Lys Leu Leu Ile Ser 
            20                  25                  30          


Val His Gly Gly Leu Gln Asn Phe Glu Leu Gln Pro Lys Leu Lys Gln 
        35                  40                  45              


Val Phe Gly Lys Gly Leu Ile Lys Ala Ala Met Thr Thr Gly Ala Trp 
    50                  55                  60                  


Ile Phe Thr Gly Gly Val Asn Thr Gly Val Ile Arg His Val Gly Asp 
65                  70                  75                  80  


Ala Leu Lys Asp His Ala Ser Lys Ser Arg Gly Lys Ile Cys Thr Ile 
                85                  90                  95      


Gly Ile Ala Pro Trp Gly Ile Val Glu Asn Gln Glu Asp Leu Ile Gly 
            100                 105                 110         


Arg Asp Val Val Arg Pro Tyr Gln Thr Met Ser Asn Pro Met Ser Lys 
        115                 120                 125             


Leu Thr Val Leu Asn Ser Met His Ser His Phe Ile Leu Ala Asp Asn 
    130                 135                 140                 


Gly Thr Thr Gly Lys Tyr Gly Ala Glu Val Lys Leu Arg Arg Gln Leu 
145                 150                 155                 160 


Glu Lys His Ile Ser Leu Gln Lys Ile Asn Thr Ser Phe His Ser Tyr 
                165                 170                 175     


Lys Thr Ala His Val Asp Leu Gln Asp Lys Arg Gln Val Lys Thr Ala 
            180                 185                 190         


Leu Glu Gln Ala Glu Trp Gln Pro Gly Arg Gly Met Phe Asp His Asp 
        195                 200                 205             


Asn Leu Met Gln Ser Thr 
    210                 

<210>  2482
<211>  536
<212>  DNA
<213>  Homo sapiens

<400>  2482
ctctacgttc acctgtgtca tagcaacagg agaaaactgc agttgacttt cgctttccaa     60

atgtcttgga aacagggctt tcaattctaa accccaactt ccactctacg gtttcctgaa    120

aattcagcat ctgtacttca gagttccact ggagaagtgg ctgacctcaa aatgtattag    180

agatcccatt gcagttaaag gtcgatggat tcaacaatgt gcagcagccc ttcaaagaat    240

acagactgtg gtttcctcct gggatgactt caccaggacc cttggcaaca gtgctggtgg    300

aaagtggaaa gaaacagtta catgagccat agatggcaga aacagtagat agaactcaca    360

tttaggcagc aggtatatga agccctgaaa ctccttggga tccctatgtt caaatgccaa    420

agcaactgtg accaactttt gccatatggc aaaaaaagac actctcttgg cctccttttt    480

ccaccagcaa tggaaaagaa aagaaataac aataataaag aaagaagagg ttggtg        536


<210>  2483
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  2483


Met Phe Lys Cys Gln Ser Asn Cys Asp Gln Leu Leu Pro Tyr Gly Lys 
1               5                   10                  15      


Lys Arg His Ser Leu Gly Leu Leu Phe Pro Pro Ala Met Glu Lys Lys 
            20                  25                  30          


Arg Asn Asn Asn Asn Lys Glu Arg Arg Gly 
        35                  40          

<210>  2484
<211>  3866
<212>  DNA
<213>  Homo sapiens

<400>  2484
tctaactcca ggctgcacag ccctccgctg cataagacac tccttccttc ctcttgagga     60

gagaaggaag agtggggagg actttgtctt gcatcttgga tgccaactca gccacagcag    120

gatagggcac tgggcagagt tgtgaggccc ccattccagg ccccagctcc cagatgacat    180

ttctagacac accctgagtc agaagtgaac ctgccacctt gaaggaaagg acccagtccg    240

gccagcattc agcatctgct aaatgaagag cgcttgggac ctgaacaacc agcagcgata    300

cccaggtaca aaggacctcc agaccagagc cagccagcag caaaaagagc atggagctga    360

ggagtacagc agcccccaga gctgagggct acagcaacgt gggcttccag aatgaagaaa    420

actttcttga gaacgagaac acatcaggaa acaactcaat aagaagcaga gctgtgcaaa    480

gcagggagca cacaaacacc aaacaggatg aagaacaggt cacagttgag caggattctc    540

caagaaacag agaacacatg gaggatgatg atgaggagat gcaacaaaaa gggtgtttgg    600

aaaggaggta tgacacagta tgtggtttct gtaggaaaca caaaacaact cttcggcaca    660

tcatctgggg cattttatta gcaggttatc tggttatggt gatttcggcc tgtgtgctga    720

actttcacag agcccttcct ctttttgtga tcaccgtggc tgccatcttc tttgttgtct    780

gggatcacct gatggccaaa tacgaacatc gaattgatga gatgctgtct cctggcagaa    840

ggcttctaaa cagccattgg ttctggctga agtgggtgat ctggagctcc ctggtcctag    900

cagttatttt ctggttggcc tttgacactg ccaaattggg tcaacagcag ctggtgtcct    960

tcggtgggct cataatgtac attgtcctgt tatttctatt ttccaagtac ccaaccagag   1020

tttactggag acctgtctta tggggaatcg ggctacagtt tcttcttggg ctcttgattc   1080

taaggactga ccctggattt atagcttttg attggttggg cagacaagtt cagacttttc   1140

tggagtacac agatgctggt gcttcatttg tctttggtga gaaatacaaa gaccacttct   1200

ttgcatttaa ggtcctgccg atcgtggttt tcttcagcac tgtgatgtcc atgctgtact   1260

acctgggact gatgcagtgg attattagaa aggttggatg gatcatgcta gttactacgg   1320

gatcatctcc tattgaatct gtagttgctt ctggcaatat atttgttgga caaacggagt   1380

ctccactgct ggtccgacca tatttacctt acatcaccaa gtctgaactc cacgccatca   1440

tgaccgccgg gttctctacc attgctggaa gcgtgctagg tgcatacatt tcttttgggg   1500

ttccatcctc ccacttgtta acagcgtcag ttatgtcagc acctgcgtca ttggctgctg   1560

ctaaactctt ttggcctgag acagaaaaac ctaaaataac cctcaagaat gccatgaaaa   1620

tggaaagtgg tgattcaggg aatcttctag aagctgcaac acagggagca tcctcctcca   1680

tctccctggt ggccaacatc gctgtgaatc tgattgcctt cctggccctg ctgtctttta   1740

tgaattcagc cctgtcctgg tttggaaaca tgtttgacta cccacagctg agttttgagc   1800

taatctgctc ctacatcttc atgccctttt ccttcatgat gggagtggaa tggcaggaca   1860

gctttatggt tgccagactc ataggttata agaccttctt caatgaattt gtggcttatg   1920

agcacctctc aaaatggatc cacttgagga aagaaggtgg acccaaattt gtaaacggtg   1980

tgcagcaata tatatcaatt cgttctgaga taatcgccac ttacgctctc tgtggttttg   2040

ccaatatcgg gtccctagga atcgtgatcg gcggactcac atccatggct ccttccagaa   2100

agcgtgatat cgcctcgggg gcagtgagag ctctgattgc ggggaccgtg gcctgcttca   2160

tgacagcctg catcgcaggc atactctcca gcactcctgt ggacatcaac tgccatcacg   2220

ttttagagaa tgccttcaac tccactttcc ctggaaacac aaccaaggtg atagcttgtt   2280

gccaaagtct gttgagcagc actgttgcca agggtcctgg tgaagtcatc ccaggaggaa   2340

accacagtct gtattctttg aagggctgct gcacattgtt gaatccatcg acctttaact   2400

gcaatgggat ctctaataca ttttgaggtc agccacttct ccagtggaac tctgaagtac   2460

agatgctgaa ttttctgctt tggaaagaaa aaaaaaagaa gctattgtcc acagattgat   2520

gcttccataa tggaatcagc tttaattgca aggaatgaag aaaaacaaga gtggaccttc   2580

aaagctacaa cattttcctc ctcccctccc tccccaccag ccccttcccc accaagaact   2640

gctatgatgt cccaaagtga ggtgttgttg attccagtct caatgggatt ttctgacttt   2700

aatgtttgca aggcatttca ccagaataca gctataaacg gccgctccca acaactgggc   2760

tctgactcac ccacacccac ttagtgtcca ctaagtagtc cagggtgact cagtttaagc   2820

acatctcagg tgaggtcact ctgcatatac cttggcttac ctgaaatagc ctgaacttga   2880

atctcacata agggaaaact agtcatcaat caccaactca ttgactaccc tcaggaagtc   2940

ctgcagaaat caagagtcct tgaggagaac acgtggatca taccaaaacc agggtttaaa   3000

tccattctgc ttaagagttc tatcagtcag tttaaccata aattacgcta cagaaacaaa   3060

caacccaaaa acctcagtgg cttacagatt tatttttcac tcacatgttt gtaatgatcc   3120

atcttggttg taatccatat tgcttcagca cccagtctaa aggagcagcc tctaaggggg   3180

gcatgttggt cttaagaggg aaaagaaagg tgggaaccac atgatggctc tttcatcttc   3240

cgctaggaaa tgataccctt tacttccatg acattccatt agccaaaaca agtcctgtga   3300

caggcacgat gtcagtcacc acagttaaat tatcctgtca tagggaggga tagtgaatat   3360

tttgcagaag taatatgata caccataagg gtacataata tccatgtctc ccttcaagga   3420

gccatcctgt tgtaggccat aacggtaggc ctattcatct gcacatttgg taatgtattc   3480

ctggtgacaa agcagctact cttcaatcaa aagccgtgta agaagcagtt gaggaaaaaa   3540

agtcctggtt gagctctgaa aaccttgcgt tgataatttc attgaccagg atggcatcag   3600

tatcaaactt gaagaatggg tgtcagtgtc taagaaaaag attccagaga caatggtggt   3660

gtgctcttta acgaaatgcc catcaccact gctcttaata gcatgaagac cacatgctgt   3720

gagaaaacac aaacatcaat taccaagtca agaaacagac actgaatgtg aaaaaggttt   3780

tgaaatacct taagtaattt attttgtttc tatttttcct tctgtttgtg tacaagagta   3840

atttaaaaga aaaagctatg tgaaaa                                        3866


<210>  2485
<211>  691
<212>  PRT
<213>  Homo sapiens

<400>  2485


Met Glu Leu Arg Ser Thr Ala Ala Pro Arg Ala Glu Gly Tyr Ser Asn 
1               5                   10                  15      


Val Gly Phe Gln Asn Glu Glu Asn Phe Leu Glu Asn Glu Asn Thr Ser 
            20                  25                  30          


Gly Asn Asn Ser Ile Arg Ser Arg Ala Val Gln Ser Arg Glu His Thr 
        35                  40                  45              


Asn Thr Lys Gln Asp Glu Glu Gln Val Thr Val Glu Gln Asp Ser Pro 
    50                  55                  60                  


Arg Asn Arg Glu His Met Glu Asp Asp Asp Glu Glu Met Gln Gln Lys 
65                  70                  75                  80  


Gly Cys Leu Glu Arg Arg Tyr Asp Thr Val Cys Gly Phe Cys Arg Lys 
                85                  90                  95      


His Lys Thr Thr Leu Arg His Ile Ile Trp Gly Ile Leu Leu Ala Gly 
            100                 105                 110         


Tyr Leu Val Met Val Ile Ser Ala Cys Val Leu Asn Phe His Arg Ala 
        115                 120                 125             


Leu Pro Leu Phe Val Ile Thr Val Ala Ala Ile Phe Phe Val Val Trp 
    130                 135                 140                 


Asp His Leu Met Ala Lys Tyr Glu His Arg Ile Asp Glu Met Leu Ser 
145                 150                 155                 160 


Pro Gly Arg Arg Leu Leu Asn Ser His Trp Phe Trp Leu Lys Trp Val 
                165                 170                 175     


Ile Trp Ser Ser Leu Val Leu Ala Val Ile Phe Trp Leu Ala Phe Asp 
            180                 185                 190         


Thr Ala Lys Leu Gly Gln Gln Gln Leu Val Ser Phe Gly Gly Leu Ile 
        195                 200                 205             


Met Tyr Ile Val Leu Leu Phe Leu Phe Ser Lys Tyr Pro Thr Arg Val 
    210                 215                 220                 


Tyr Trp Arg Pro Val Leu Trp Gly Ile Gly Leu Gln Phe Leu Leu Gly 
225                 230                 235                 240 


Leu Leu Ile Leu Arg Thr Asp Pro Gly Phe Ile Ala Phe Asp Trp Leu 
                245                 250                 255     


Gly Arg Gln Val Gln Thr Phe Leu Glu Tyr Thr Asp Ala Gly Ala Ser 
            260                 265                 270         


Phe Val Phe Gly Glu Lys Tyr Lys Asp His Phe Phe Ala Phe Lys Val 
        275                 280                 285             


Leu Pro Ile Val Val Phe Phe Ser Thr Val Met Ser Met Leu Tyr Tyr 
    290                 295                 300                 


Leu Gly Leu Met Gln Trp Ile Ile Arg Lys Val Gly Trp Ile Met Leu 
305                 310                 315                 320 


Val Thr Thr Gly Ser Ser Pro Ile Glu Ser Val Val Ala Ser Gly Asn 
                325                 330                 335     


Ile Phe Val Gly Gln Thr Glu Ser Pro Leu Leu Val Arg Pro Tyr Leu 
            340                 345                 350         


Pro Tyr Ile Thr Lys Ser Glu Leu His Ala Ile Met Thr Ala Gly Phe 
        355                 360                 365             


Ser Thr Ile Ala Gly Ser Val Leu Gly Ala Tyr Ile Ser Phe Gly Val 
    370                 375                 380                 


Pro Ser Ser His Leu Leu Thr Ala Ser Val Met Ser Ala Pro Ala Ser 
385                 390                 395                 400 


Leu Ala Ala Ala Lys Leu Phe Trp Pro Glu Thr Glu Lys Pro Lys Ile 
                405                 410                 415     


Thr Leu Lys Asn Ala Met Lys Met Glu Ser Gly Asp Ser Gly Asn Leu 
            420                 425                 430         


Leu Glu Ala Ala Thr Gln Gly Ala Ser Ser Ser Ile Ser Leu Val Ala 
        435                 440                 445             


Asn Ile Ala Val Asn Leu Ile Ala Phe Leu Ala Leu Leu Ser Phe Met 
    450                 455                 460                 


Asn Ser Ala Leu Ser Trp Phe Gly Asn Met Phe Asp Tyr Pro Gln Leu 
465                 470                 475                 480 


Ser Phe Glu Leu Ile Cys Ser Tyr Ile Phe Met Pro Phe Ser Phe Met 
                485                 490                 495     


Met Gly Val Glu Trp Gln Asp Ser Phe Met Val Ala Arg Leu Ile Gly 
            500                 505                 510         


Tyr Lys Thr Phe Phe Asn Glu Phe Val Ala Tyr Glu His Leu Ser Lys 
        515                 520                 525             


Trp Ile His Leu Arg Lys Glu Gly Gly Pro Lys Phe Val Asn Gly Val 
    530                 535                 540                 


Gln Gln Tyr Ile Ser Ile Arg Ser Glu Ile Ile Ala Thr Tyr Ala Leu 
545                 550                 555                 560 


Cys Gly Phe Ala Asn Ile Gly Ser Leu Gly Ile Val Ile Gly Gly Leu 
                565                 570                 575     


Thr Ser Met Ala Pro Ser Arg Lys Arg Asp Ile Ala Ser Gly Ala Val 
            580                 585                 590         


Arg Ala Leu Ile Ala Gly Thr Val Ala Cys Phe Met Thr Ala Cys Ile 
        595                 600                 605             


Ala Gly Ile Leu Ser Ser Thr Pro Val Asp Ile Asn Cys His His Val 
    610                 615                 620                 


Leu Glu Asn Ala Phe Asn Ser Thr Phe Pro Gly Asn Thr Thr Lys Val 
625                 630                 635                 640 


Ile Ala Cys Cys Gln Ser Leu Leu Ser Ser Thr Val Ala Lys Gly Pro 
                645                 650                 655     


Gly Glu Val Ile Pro Gly Gly Asn His Ser Leu Tyr Ser Leu Lys Gly 
            660                 665                 670         


Cys Cys Thr Leu Leu Asn Pro Ser Thr Phe Asn Cys Asn Gly Ile Ser 
        675                 680                 685             


Asn Thr Phe 
    690     

<210>  2486
<211>  897
<212>  DNA
<213>  Homo sapiens

<400>  2486
ctcgcccgga ccacgtgatc cgtgcggcca gggtagctat cgcggcggcg gcggcggcgg     60

cggttgaact gactcggagc gaggagaccc gagcgagcag acgcggccct ggcgcccgcc    120

ctgcgcactc accatggcga tgcatttcat cttctcagat acagcggtgc ttctgtttga    180

tttctggagt gtccacagtc ctgctggcat ggccctttcg gtgttggtgc tcctgcttct    240

ggctgtactg tatgaaggca tcaaggttgg caaagccaag ctgctcaacc aggtactggt    300

gaacctgcca acctccatca gccagcagac catcgcagag acagacgggg actctgcagg    360

ctcagattca ttccctgttg gcagaaccca ccacaggtgg tatttgtgtc actttggcca    420

gtctctaatc catgtcatcc aggtggtcat cggctacttc atcatgctgg ccgtaatgtc    480

ctacaacacc tggattttcc ttggtgtggt cttgggctct gctgtgggct actacctagc    540

ttacccactt ctcactttct tctatgcaga acaaaaagct gcatctaata atgttcaata    600

cttaatattc tctatttatt acttactgct tactcgtaat gatctagtgg ggaaacatga    660

ttcattcact taaaatactg attaagccat gggcaggtac tgactgaaga tgcaatccaa    720

ccaaagccat tacatttttt gagttagatg ggactctctg gatagttgaa cctcttcact    780

ttataaaaaa ggaaagagag aaaatcactg ctgtatacta aatacctcac agattagatg    840

aaaagatggt tgtaagcttt gggaattaaa aacaaacaaa tacattttag taaatat       897


<210>  2487
<211>  179
<212>  PRT
<213>  Homo sapiens

<400>  2487


Met Ala Met His Phe Ile Phe Ser Asp Thr Ala Val Leu Leu Phe Asp 
1               5                   10                  15      


Phe Trp Ser Val His Ser Pro Ala Gly Met Ala Leu Ser Val Leu Val 
            20                  25                  30          


Leu Leu Leu Leu Ala Val Leu Tyr Glu Gly Ile Lys Val Gly Lys Ala 
        35                  40                  45              


Lys Leu Leu Asn Gln Val Leu Val Asn Leu Pro Thr Ser Ile Ser Gln 
    50                  55                  60                  


Gln Thr Ile Ala Glu Thr Asp Gly Asp Ser Ala Gly Ser Asp Ser Phe 
65                  70                  75                  80  


Pro Val Gly Arg Thr His His Arg Trp Tyr Leu Cys His Phe Gly Gln 
                85                  90                  95      


Ser Leu Ile His Val Ile Gln Val Val Ile Gly Tyr Phe Ile Met Leu 
            100                 105                 110         


Ala Val Met Ser Tyr Asn Thr Trp Ile Phe Leu Gly Val Val Leu Gly 
        115                 120                 125             


Ser Ala Val Gly Tyr Tyr Leu Ala Tyr Pro Leu Leu Thr Phe Phe Tyr 
    130                 135                 140                 


Ala Glu Gln Lys Ala Ala Ser Asn Asn Val Gln Tyr Leu Ile Phe Ser 
145                 150                 155                 160 


Ile Tyr Tyr Leu Leu Leu Thr Arg Asn Asp Leu Val Gly Lys His Asp 
                165                 170                 175     


Ser Phe Thr 
            

<210>  2488
<211>  962
<212>  DNA
<213>  Homo sapiens

<400>  2488
ctcgcccgga ccacgtgatc cgtgcggcca gggtagctat cgcggcggcg gcggcggcgg     60

cggttgaact gactcggagc gaggagaccc gagcgagcag acgcggccct ggcgcccgcc    120

ctgcgcactc accatggcga tgcatttcat cttctcagat acagcggtgc ttctgtttga    180

tttctggagt gtccacagtc ctgctggcat ggccctttcg gtgttggtgc tcctgcttct    240

ggctgtactg tatgaaggca tcaaggttgg caaagccaag ctgctcaacc aggtactggt    300

gaacctgcca acctccatca gccagcagac catcgcagag acagacgggg actctgcagg    360

ctcagattca ttccctgttg gcagaaccca ccacaggtgg tatttgtgtc actttggcca    420

gtctctaatc catgtcatcc aggtggtcat cggctacttc atcatgctgg ccgtaatgtc    480

ctacaacacc tggattttcc ttggtgtggt cttgggctct gctgtgggct actacctagc    540

ttacccactt ctcactttct tctatgcaga acaaaaagct gcatctaata atgttcaata    600

cttaatattc tctatttatt acttactgct tactcgtaat gatctagtgg ggaaacatga    660

ttcattcact taaaatactg attaagccat gggcaggtac tgactgaaga tgcaatccaa    720

ccaaagccat tacatttttt gagttagatg ggactctctg gatagttgaa cctcttcact    780

ttataaaaaa ggaaagagag aaaatcactg ctgtatacta aatacctcac agattagatg    840

aaaagatggt tgtaagcttt gggaattaaa aacaaacaaa tacattttag taaatatata    900

tttttaaata gtctatgact gttctgttct cctaattcca acagaaagca catgaaccct    960

tg                                                                   962


<210>  2489
<211>  179
<212>  PRT
<213>  Homo sapiens

<400>  2489


Met Ala Met His Phe Ile Phe Ser Asp Thr Ala Val Leu Leu Phe Asp 
1               5                   10                  15      


Phe Trp Ser Val His Ser Pro Ala Gly Met Ala Leu Ser Val Leu Val 
            20                  25                  30          


Leu Leu Leu Leu Ala Val Leu Tyr Glu Gly Ile Lys Val Gly Lys Ala 
        35                  40                  45              


Lys Leu Leu Asn Gln Val Leu Val Asn Leu Pro Thr Ser Ile Ser Gln 
    50                  55                  60                  


Gln Thr Ile Ala Glu Thr Asp Gly Asp Ser Ala Gly Ser Asp Ser Phe 
65                  70                  75                  80  


Pro Val Gly Arg Thr His His Arg Trp Tyr Leu Cys His Phe Gly Gln 
                85                  90                  95      


Ser Leu Ile His Val Ile Gln Val Val Ile Gly Tyr Phe Ile Met Leu 
            100                 105                 110         


Ala Val Met Ser Tyr Asn Thr Trp Ile Phe Leu Gly Val Val Leu Gly 
        115                 120                 125             


Ser Ala Val Gly Tyr Tyr Leu Ala Tyr Pro Leu Leu Thr Phe Phe Tyr 
    130                 135                 140                 


Ala Glu Gln Lys Ala Ala Ser Asn Asn Val Gln Tyr Leu Ile Phe Ser 
145                 150                 155                 160 


Ile Tyr Tyr Leu Leu Leu Thr Arg Asn Asp Leu Val Gly Lys His Asp 
                165                 170                 175     


Ser Phe Thr 
            

<210>  2490
<211>  1773
<212>  DNA
<213>  Homo sapiens

<400>  2490
gatccgtgcg gccagggtag ctatcgcggc ggcggcggcg gcggcggttg aactgactcg     60

gagcgaggag acccgagcga gcagacgcgg ccctggcgcc cgccctgcgc actcaccatg    120

gcgatgcatt tcatcttctc agatacagcg gtgcttctgt ttgatttctg gagtgtccac    180

agtcctgctg gcatggccct ttcggtgttg gtgctcctgc ttctggctgt actgtatgaa    240

ggcatcaagg ttggcaaagc caagctgctc aaccaggtac tggtgaacct gccaacctcc    300

atcagccagc agaccatcgc agagacagac ggggactctg caggctcaga ttcattccct    360

gttggcagaa cccaccacag gtggtatttg tgtcactttg gccagtctct aatccatgtc    420

atccaggtgg tcatcggcta cttcatcatg ctggccgtaa tgtcctacaa cacctggatt    480

ttccttggtg tggtcttggg ctctgctgtg ggctactacc tagcttaccc acttctcagc    540

acagcttagc tggtgaggaa cgtgcaggca ctgaggctgg agggacatgg agccccctct    600

tccagacact atacttccaa ctgccctttc ttctgatggc tattcctcca ccttattccc    660

agcccctgga aactttgagc tgaagccagc acttgctccc tggagttcgg aagccattgc    720

agcaaccttc cttctcagcc agcctacgta gggcccaggc atggtcttgt gtcttaagac    780

agctgctgtg accaaaggga gaatggagat aacaggggtg gcagggttac tgagcccatg    840

acaatgcttc tctgtgactc aaaccaggaa tttccaaaga tttcaagcca gggagaaggg    900

ttcttggtga tgcagggcat ggaacctgga caccctcagc tctcctgctt tgtgccttat    960

ctacaggagc atcgcccatt ggacttcctg acctcttctg tctttgaggg acagagacca   1020

agctagatcc tttttctcac ctttctgcct ttggaacaca tgaagatcat ctcgtctatg   1080

gatcatgttg acaaactaag ttttttttat ttttcccatt gaactcctag ttggcaattt   1140

tgcacattca tacaaaaaaa tttttaatga aatgatttca ttgattcatg atggatggca   1200

gaaactgctg agacctattt ccctttcttg gggagagaat aagtgacagc tgattaaagg   1260

cagagacaca ggactgcttt caggctcctg gtttattctc tgatagactg agctccttcc   1320

accagaaggc actgcctgca ggaagaagat gatctgatgg ccgtgggtgt ctgggaagct   1380

cttcgtggcc tcaatgccct cctttatcct catctttctt ctatgcagaa caaaaagctg   1440

catctaataa tgttcaatac ttaatattct ctatttatta cttactgctt actcgtaatg   1500

atctagtggg gaaacatgat tcattcactt aaaatactga ttaagccatg ggcaggtact   1560

gactgaagat gcaatccaac caaagccatt acattttttg agttagatgg gactctctgg   1620

atagttgaac ctcttcactt tataaaaaag gaaagagaga aaatcactgc tgtatactaa   1680

atacctcaca gattagatga aaagatggtt gtaagctttg ggaattaaaa acaaacaaat   1740

acattttagt aaatatatat ttttaaatag tct                                1773


<210>  2491
<211>  143
<212>  PRT
<213>  Homo sapiens

<400>  2491


Met Ala Met His Phe Ile Phe Ser Asp Thr Ala Val Leu Leu Phe Asp 
1               5                   10                  15      


Phe Trp Ser Val His Ser Pro Ala Gly Met Ala Leu Ser Val Leu Val 
            20                  25                  30          


Leu Leu Leu Leu Ala Val Leu Tyr Glu Gly Ile Lys Val Gly Lys Ala 
        35                  40                  45              


Lys Leu Leu Asn Gln Val Leu Val Asn Leu Pro Thr Ser Ile Ser Gln 
    50                  55                  60                  


Gln Thr Ile Ala Glu Thr Asp Gly Asp Ser Ala Gly Ser Asp Ser Phe 
65                  70                  75                  80  


Pro Val Gly Arg Thr His His Arg Trp Tyr Leu Cys His Phe Gly Gln 
                85                  90                  95      


Ser Leu Ile His Val Ile Gln Val Val Ile Gly Tyr Phe Ile Met Leu 
            100                 105                 110         


Ala Val Met Ser Tyr Asn Thr Trp Ile Phe Leu Gly Val Val Leu Gly 
        115                 120                 125             


Ser Ala Val Gly Tyr Tyr Leu Ala Tyr Pro Leu Leu Ser Thr Ala 
    130                 135                 140             

<210>  2492
<211>  1821
<212>  DNA
<213>  Homo sapiens

<400>  2492
gatccgtgcg gccagggtag ctatcgcggc ggcggcggcg gcggcggttg aactgactcg     60

gagcgaggag acccgagcga gcagacgcgg ccctggcgcc cgccctgcgc actcaccatg    120

gcgatgcatt tcatcttctc agatacagcg gtgcttctgt ttgatttctg gagtgtccac    180

agtcctgctg gcatggccct ttcggtgttg gtgctcctgc ttctggctgt actgtatgaa    240

ggcatcaagg ttggcaaagc caagctgctc aaccaggtac tggtgaacct gccaacctcc    300

atcagccagc agaccatcgc agagacagac ggggactctg caggctcaga ttcattccct    360

gttggcagaa cccaccacag gtggtatttg tgtcactttg gccagtctct aatccatgtc    420

atccaggtgg tcatcggcta cttcatcatg ctggccgtaa tgtcctacaa cacctggatt    480

ttccttggtg tggtcttggg ctctgctgtg ggctactacc tagcttaccc acttctcagc    540

acagcttagc tggtgaggaa cgtgcaggca ctgaggctgg agggacatgg agccccctct    600

tccagacact atacttccaa ctgccctttc ttctgatggc tattcctcca ccttattccc    660

agcccctgga aactttgagc tgaagccagc acttgctccc tggagttcgg aagccattgc    720

agcaaccttc cttctcagcc agcctacgta gggcccaggc atggtcttgt gtcttaagac    780

agctgctgtg accaaaggga gaatggagat aacaggggtg gcagggttac tgagcccatg    840

acaatgcttc tctgtgactc aaaccaggaa tttccaaaga tttcaagcca gggagaaggg    900

ttcttggtga tgcagggcat ggaacctgga caccctcagc tctcctgctt tgtgccttat    960

ctacaggagc atcgcccatt ggacttcctg acctcttctg tctttgaggg acagagacca   1020

agctagatcc tttttctcac ctttctgcct ttggaacaca tgaagatcat ctcgtctatg   1080

gatcatgttg acaaactaag ttttttttat ttttcccatt gaactcctag ttggcaattt   1140

tgcacattca tacaaaaaaa tttttaatga aatgatttca ttgattcatg atggatggca   1200

gaaactgctg agacctattt ccctttcttg gggagagaat aagtgacagc tgattaaagg   1260

cagagacaca ggactgcttt caggctcctg gtttattctc tgatagactg agctccttcc   1320

accagaaggc actgcctgca ggaagaagat gatctgatgg ccgtgggtgt ctgggaagct   1380

cttcgtggcc tcaatgccct cctttatcct catctttctt ctatgcagaa caaaaagctg   1440

catctaataa tgttcaatac ttaatattct ctatttatta cttactgctt actcgtaatg   1500

atctagtggg gaaacatgat tcattcactt aaaatactga ttaagccatg ggcaggtact   1560

gactgaagat gcaatccaac caaagccatt acattttttg agttagatgg gactctctgg   1620

atagttgaac ctcttcactt tataaaaaag gaaagagaga aaatcactgc tgtatactaa   1680

atacctcaca gattagatga aaagatggtt gtaagctttg ggaattaaaa acaaacaaat   1740

acattttagt aaatatatat ttttaaatag tctatgactg ttctgttctc ctaattccaa   1800

cagaaagcac atgaaccctt g                                             1821


<210>  2493
<211>  143
<212>  PRT
<213>  Homo sapiens

<400>  2493


Met Ala Met His Phe Ile Phe Ser Asp Thr Ala Val Leu Leu Phe Asp 
1               5                   10                  15      


Phe Trp Ser Val His Ser Pro Ala Gly Met Ala Leu Ser Val Leu Val 
            20                  25                  30          


Leu Leu Leu Leu Ala Val Leu Tyr Glu Gly Ile Lys Val Gly Lys Ala 
        35                  40                  45              


Lys Leu Leu Asn Gln Val Leu Val Asn Leu Pro Thr Ser Ile Ser Gln 
    50                  55                  60                  


Gln Thr Ile Ala Glu Thr Asp Gly Asp Ser Ala Gly Ser Asp Ser Phe 
65                  70                  75                  80  


Pro Val Gly Arg Thr His His Arg Trp Tyr Leu Cys His Phe Gly Gln 
                85                  90                  95      


Ser Leu Ile His Val Ile Gln Val Val Ile Gly Tyr Phe Ile Met Leu 
            100                 105                 110         


Ala Val Met Ser Tyr Asn Thr Trp Ile Phe Leu Gly Val Val Leu Gly 
        115                 120                 125             


Ser Ala Val Gly Tyr Tyr Leu Ala Tyr Pro Leu Leu Ser Thr Ala 
    130                 135                 140             

<210>  2494
<211>  1173
<212>  DNA
<213>  Homo sapiens

<400>  2494
gggtagctat cgcggcggcg gcggcggcgg cggttgaact gactcggagc gaggagaccc     60

gagcgagcag acgcggccct ggcgcccgcc ctgcgcactc accatggcga tgcatttcat    120

cttctcagat acagcggtgc ttctgtttga tttctggagt gtccacagtc ctgctggcat    180

ggccctttcg gtgttggtgc tcctgcttct ggctgtactg tatgaaggca tcaaggttgg    240

caaagccaag ctgctcaacc aggtactggt gaacctgcca acctccatca gccagcagac    300

catcgcagag acagacgggg actctgcagg ctcagattca ttccctgttg gcagaaccca    360

ccacaggagc atcgcccatt ggacttcctg acctcttctg tctttgaggg acagagacca    420

agctagatcc tttttctcac ctttctgcct ttggaacaca tgaagatcat ctcgtctatg    480

gatcatgttg acaaactaag ttttttttat ttttcccatt gaactcctag ttggcaattt    540

tgcacattca tacaaaaaaa tttttaatga aatgatttca ttgattcatg atggatggca    600

gaaactgctg agacctattt ccctttcttg gggagagaat aagtgacagc tgattaaagg    660

cagagacaca ggactgcttt caggctcctg gtttattctc tgatagactg agctccttcc    720

accagaaggc actgcctgca ggaagaagat gatctgatgg ccgtgggtgt ctgggaagct    780

cttcgtggcc tcaatgccct cctttatcct catctttctt ctatgcagaa caaaaagctg    840

catctaataa tgttcaatac ttaatattct ctatttatta cttactgctt actcgtaatg    900

atctagtggg gaaacatgat tcattcactt aaaatactga ttaagccatg ggcaggtact    960

gactgaagat gcaatccaac caaagccatt acattttttg agttagatgg gactctctgg   1020

atagttgaac ctcttcactt tataaaaaag gaaagagaga aaatcactgc tgtatactaa   1080

atacctcaca gattagatga aaagatggtt gtaagctttg ggaattaaaa acaaacaaat   1140

acattttagt aaatatatat ttttaaatag tct                                1173


<210>  2495
<211>  95
<212>  PRT
<213>  Homo sapiens

<400>  2495


Met Ala Met His Phe Ile Phe Ser Asp Thr Ala Val Leu Leu Phe Asp 
1               5                   10                  15      


Phe Trp Ser Val His Ser Pro Ala Gly Met Ala Leu Ser Val Leu Val 
            20                  25                  30          


Leu Leu Leu Leu Ala Val Leu Tyr Glu Gly Ile Lys Val Gly Lys Ala 
        35                  40                  45              


Lys Leu Leu Asn Gln Val Leu Val Asn Leu Pro Thr Ser Ile Ser Gln 
    50                  55                  60                  


Gln Thr Ile Ala Glu Thr Asp Gly Asp Ser Ala Gly Ser Asp Ser Phe 
65                  70                  75                  80  


Pro Val Gly Arg Thr His His Arg Ser Ile Ala His Trp Thr Ser 
                85                  90                  95  

<210>  2496
<211>  1221
<212>  DNA
<213>  Homo sapiens

<400>  2496
gggtagctat cgcggcggcg gcggcggcgg cggttgaact gactcggagc gaggagaccc     60

gagcgagcag acgcggccct ggcgcccgcc ctgcgcactc accatggcga tgcatttcat    120

cttctcagat acagcggtgc ttctgtttga tttctggagt gtccacagtc ctgctggcat    180

ggccctttcg gtgttggtgc tcctgcttct ggctgtactg tatgaaggca tcaaggttgg    240

caaagccaag ctgctcaacc aggtactggt gaacctgcca acctccatca gccagcagac    300

catcgcagag acagacgggg actctgcagg ctcagattca ttccctgttg gcagaaccca    360

ccacaggagc atcgcccatt ggacttcctg acctcttctg tctttgaggg acagagacca    420

agctagatcc tttttctcac ctttctgcct ttggaacaca tgaagatcat ctcgtctatg    480

gatcatgttg acaaactaag ttttttttat ttttcccatt gaactcctag ttggcaattt    540

tgcacattca tacaaaaaaa tttttaatga aatgatttca ttgattcatg atggatggca    600

gaaactgctg agacctattt ccctttcttg gggagagaat aagtgacagc tgattaaagg    660

cagagacaca ggactgcttt caggctcctg gtttattctc tgatagactg agctccttcc    720

accagaaggc actgcctgca ggaagaagat gatctgatgg ccgtgggtgt ctgggaagct    780

cttcgtggcc tcaatgccct cctttatcct catctttctt ctatgcagaa caaaaagctg    840

catctaataa tgttcaatac ttaatattct ctatttatta cttactgctt actcgtaatg    900

atctagtggg gaaacatgat tcattcactt aaaatactga ttaagccatg ggcaggtact    960

gactgaagat gcaatccaac caaagccatt acattttttg agttagatgg gactctctgg   1020

atagttgaac ctcttcactt tataaaaaag gaaagagaga aaatcactgc tgtatactaa   1080

atacctcaca gattagatga aaagatggtt gtaagctttg ggaattaaaa acaaacaaat   1140

acattttagt aaatatatat ttttaaatag tctatgactg ttctgttctc ctaattccaa   1200

cagaaagcac atgaaccctt g                                             1221


<210>  2497
<211>  95
<212>  PRT
<213>  Homo sapiens

<400>  2497


Met Ala Met His Phe Ile Phe Ser Asp Thr Ala Val Leu Leu Phe Asp 
1               5                   10                  15      


Phe Trp Ser Val His Ser Pro Ala Gly Met Ala Leu Ser Val Leu Val 
            20                  25                  30          


Leu Leu Leu Leu Ala Val Leu Tyr Glu Gly Ile Lys Val Gly Lys Ala 
        35                  40                  45              


Lys Leu Leu Asn Gln Val Leu Val Asn Leu Pro Thr Ser Ile Ser Gln 
    50                  55                  60                  


Gln Thr Ile Ala Glu Thr Asp Gly Asp Ser Ala Gly Ser Asp Ser Phe 
65                  70                  75                  80  


Pro Val Gly Arg Thr His His Arg Ser Ile Ala His Trp Thr Ser 
                85                  90                  95  

<210>  2498
<211>  599
<212>  DNA
<213>  Homo sapiens

<400>  2498
gggtagctat cgcggcggcg gcggcggcgg cggttgaact gactcggagc gaggagaccc     60

gagcgagcag acgcggccct ggcgcccgcc ctgcgcactc accatggcga tgcatttcat    120

cttctcagat acagcggtgc ttctgtttga tttctggagt gtccacagtc ctgctggcat    180

ggccctttcg gtgttggtgc tcctgcttct ggctgtactg tatgaaggca tcaaggttgg    240

caaagccaag ctgctcaacc aggtactggt gaacctgcca acctccatca gccagcagac    300

catcgcagag acagacgggg actctgcagg ctcagattca ttccctgttg gcagaaccca    360

ccacagggca gaattgctat tctggattct caaatgaaaa tttaactctt gagaagaaag    420

actcatggaa ggaactggta cattccccaa aggaacacag gcaagaggga agggctccga    480

tacatgcaag ctggagcata gatccatcac agctctctgc tcaaggtttt ggcaaaaggc    540

aaaatccact ctggctgata catgagggga caaaatttgc cccattcacc ctcatattt     599


<210>  2499
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  2499


Met Ala Met His Phe Ile Phe Ser Asp Thr Ala Val Leu Leu Phe Asp 
1               5                   10                  15      


Phe Trp Ser Val His Ser Pro Ala Gly Met Ala Leu Ser Val Leu Val 
            20                  25                  30          


Leu Leu Leu Leu Ala Val Leu Tyr Glu Gly Ile Lys Val Gly Lys Ala 
        35                  40                  45              


Lys Leu Leu Asn Gln Val Leu Val Asn Leu Pro Thr Ser Ile Ser Gln 
    50                  55                  60                  


Gln Thr Ile Ala Glu Thr Asp Gly Asp Ser Ala Gly Ser Asp Ser Phe 
65                  70                  75                  80  


Pro Val Gly Arg Thr His His Arg Ala Glu Leu Leu Phe Trp Ile Leu 
                85                  90                  95      


Lys 
    

<210>  2500
<211>  1305
<212>  DNA
<213>  Homo sapiens

<400>  2500
agctatcgcg gcggcggcgg cggcggcggt tgaactgact cggagcgagg agacccgagc     60

gagcagacgc ggccctggcg cccgccctgc gcactcacca tggcgggttc acctgggctg    120

gagagaacga cagcttgcaa gactcgttcg tctttgaaga agtcatatca ttttcttcat    180

cccatgaaga atgtcataga atttaagata caggaagctc agcctgggca acatagctag    240

accccgtctc tacaaaaatt agccacaagt ggtggcaggc gcctgtaatc ccagctactc    300

ggaggctgag gcaggatgag gaggattgct tgagcccaga agttccaggc tgcagtgagc    360

catgaccttc ggcctgggca acagaacaag acgtcctcaa acaaacaaaa caaaaaaaaa    420

aagatatagg aagtgtatgt aggccattta gtgaaatgat cagccgtcct ttaaaaaggg    480

aaatagatgg aaagcacttg caaaagttcc ccagccagtc agcctagcaa ctgggacctt    540

catctccttc ccaacccttg tttacaaata aggaagcttt tctcaaagtg taagtaaccc    600

caaatgaaga aatatagaag aaaacaagtt ccagggattg ctccctcctt caccacagcc    660

ccaccctgaa aaaagcacaa atcagttaaa ctttcagagg ccaagattca tcccaagtag    720

gaaaacaaga ttggggccct gccccttgcc tatctgacca caaagccctt taattgaaaa    780

ctgtagccca gatcgcttct ctcaagtcag ggtgtgctga cttccatctt ttcctctagc    840

aaaaaggcaa aagtagaaag ggttgagtga caggtgagtc ttcgtccctc tggggcttcg    900

gactccgtgg gtgtttccag ctctgaacaa accatacagt tcatcttccc agctatctcc    960

tgcttctctg gcttcagaac catcctagcc aactgctctc tggccagggc aggtgtctct   1020

caggcggctt ggtccccagc acccccaggg agcctccact gtgcctccct ttctctgacc   1080

tacaacctgt tgtaattatt tgctcactta aatgtccccc ctcatagaca ggtagctccc   1140

taagggccaa agacttgtcc cattcatctc tgtatcgcca gggtctgcac agacctagca   1200

caacaaaaag aaatctttca aattactctt actgttctgt gggtgttcag gtctatggca   1260

aaacatgtct gggctgtttt gggctcctaa gataactggc ccagg                   1305


<210>  2501
<211>  46
<212>  PRT
<213>  Homo sapiens

<400>  2501


Met Ala Gly Ser Pro Gly Leu Glu Arg Thr Thr Ala Cys Lys Thr Arg 
1               5                   10                  15      


Ser Ser Leu Lys Lys Ser Tyr His Phe Leu His Pro Met Lys Asn Val 
            20                  25                  30          


Ile Glu Phe Lys Ile Gln Glu Ala Gln Pro Gly Gln His Ser 
        35                  40                  45      

<210>  2502
<211>  585
<212>  DNA
<213>  Homo sapiens

<400>  2502
agctatcgcg gcggcggcgg cggcggcggt tgaactgact cggagcgagg agacccgagc     60

gagcagacgc ggccctggcg cccgccctgc gcactcacca tggcgatgca tttcatcttc    120

tcagatacag cggtgcttct gtttgatttc tggagtgtcc acagtcctgc tggtaagaat    180

tggggacctc agacttgtag cttggaaagc cttgtagtac taggcaaggg agaatctggg    240

ttctcttgat tctctgtggg catttaagtg aggctgattc ctctggcata aacactgagc    300

aggaacttca cagttataat tccatttgta accactcccc ttcagatcgc aaagggctcc    360

attatcttac tgatcctcac aaaggccgag aggcagggag gcagcttttc cctctgttac    420

agggcaagaa actaaagccc agagacagga agagagactc gtgcagggtc acacagtaag    480

tacgcatcag agccactact agatcaaggc ctccgggtgt cacctggcac ctcccttatc    540

cagggctcat tgttctgcac cagttcagaa gcccacagca gctgc                    585


<210>  2503
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  2503


Met Ala Met His Phe Ile Phe Ser Asp Thr Ala Val Leu Leu Phe Asp 
1               5                   10                  15      


Phe Trp Ser Val His Ser Pro Ala Gly Lys Asn Trp Gly Pro Gln Thr 
            20                  25                  30          


Cys Ser Leu Glu Ser Leu Val Val Leu Gly Lys Gly Glu Ser Gly Phe 
        35                  40                  45              


Ser 
    

<210>  2504
<211>  1856
<212>  DNA
<213>  Homo sapiens

<400>  2504
gactcggagc gaggagaccc gagcgagcag acgcggccct ggcgcccgcc ctgcgcactc     60

accatggcga tgcatttcat cttctcagat acagcggtgc ttctgtttga tttctggagt    120

gtccacagtc ctgctgggca agaaactaaa gcccagagac aggaagagag actcgtgcag    180

ggtcacacag taatcttcat atggaggaat gattgatgac ctcattggcc actggtgatc    240

aattcaacct tcagtccctg tctccttcca gaggcatggc cctttcggtg ttggtgctcc    300

tgcttctggc tgtactgtat gaaggcatca aggttggcaa agccaagctg ctcaaccagg    360

tactggtgaa cctgccaacc tccatcagcc agcagaccat cgcagagaca gacggggact    420

ctgcaggctc agattcattc cctgttggca gaacccacca caggtggtat ttgtgtcact    480

ttggccagtc tctaatccat gtcatccagg tggtcatcgg ctacttcatc atgctggccg    540

taatgtccta caacacctgg attttccttg gtgtggtctt gggctctgct gtgggctact    600

acctagctta cccacttctc agcacagctt agctggtgag gaacgtgcag gcactgaggc    660

tggagggaca tggagccccc tcttccagac actatacttc caactgccct ttcttctgat    720

ggctattcct ccaccttatt cccagcccct ggaaactttg agctgaagcc agcacttgct    780

ccctggagtt cggaagccat tgcagcaacc ttccttctca gccagcctac gtagggccca    840

ggcatggtct tgtgtcttaa gacagctgct gtgaccaaag ggagaatgga gataacaggg    900

gtggcagggt tactgagccc atgacaatgc ttctctgtga ctcaaaccag gaatttccaa    960

agatttcaag ccagggagaa gggttcttgg tgatgcaggg catggaacct ggacaccctc   1020

agctctcctg ctttgtgcct tatctacagg agcatcgccc attggacttc ctgacctctt   1080

ctgtctttga gggacagaga ccaagctaga tcctttttct cacctttctg cctttggaac   1140

acatgaagat catctcgtct atggatcatg ttgacaaact aagttttttt tatttttccc   1200

attgaactcc tagttggcaa ttttgcacat tcatacaaaa aaatttttaa tgaaatgatt   1260

tcattgattc atgatggatg gcagaaactg ctgagaccta tttccctttc ttggggagag   1320

aataagtgac agctgattaa aggcagagac acaggactgc tttcaggctc ctggtttatt   1380

ctctgataga ctgagctcct tccaccagaa ggcactgcct gcaggaagaa gatgatctga   1440

tggccgtggg tgtctgggaa gctcttcgtg gcctcaatgc cctcctttat cctcatcttt   1500

cttctatgca gaacaaaaag ctgcatctaa taatgttcaa tacttaatat tctctattta   1560

ttacttactg cttactcgta atgatctagt ggggaaacat gattcattca cttaaaatac   1620

tgattaagcc atgggcaggt actgactgaa gatgcaatcc aaccaaagcc attacatttt   1680

ttgagttaga tgggactctc tggatagttg aacctcttca ctttataaaa aaggaaagag   1740

agaaaatcac tgctgtatac taaatacctc acagattaga tgaaaagatg gttgtaagct   1800

ttgggaatta aaaacaaaca aatacatttt agtaaatata tatttttaaa tagtct       1856


<210>  2505
<211>  138
<212>  PRT
<213>  Homo sapiens

<400>  2505


Met Thr Ser Leu Ala Thr Gly Asp Gln Phe Asn Leu Gln Ser Leu Ser 
1               5                   10                  15      


Pro Ser Arg Gly Met Ala Leu Ser Val Leu Val Leu Leu Leu Leu Ala 
            20                  25                  30          


Val Leu Tyr Glu Gly Ile Lys Val Gly Lys Ala Lys Leu Leu Asn Gln 
        35                  40                  45              


Val Leu Val Asn Leu Pro Thr Ser Ile Ser Gln Gln Thr Ile Ala Glu 
    50                  55                  60                  


Thr Asp Gly Asp Ser Ala Gly Ser Asp Ser Phe Pro Val Gly Arg Thr 
65                  70                  75                  80  


His His Arg Trp Tyr Leu Cys His Phe Gly Gln Ser Leu Ile His Val 
                85                  90                  95      


Ile Gln Val Val Ile Gly Tyr Phe Ile Met Leu Ala Val Met Ser Tyr 
            100                 105                 110         


Asn Thr Trp Ile Phe Leu Gly Val Val Leu Gly Ser Ala Val Gly Tyr 
        115                 120                 125             


Tyr Leu Ala Tyr Pro Leu Leu Ser Thr Ala 
    130                 135             

<210>  2506
<211>  1904
<212>  DNA
<213>  Homo sapiens

<400>  2506
gactcggagc gaggagaccc gagcgagcag acgcggccct ggcgcccgcc ctgcgcactc     60

accatggcga tgcatttcat cttctcagat acagcggtgc ttctgtttga tttctggagt    120

gtccacagtc ctgctgggca agaaactaaa gcccagagac aggaagagag actcgtgcag    180

ggtcacacag taatcttcat atggaggaat gattgatgac ctcattggcc actggtgatc    240

aattcaacct tcagtccctg tctccttcca gaggcatggc cctttcggtg ttggtgctcc    300

tgcttctggc tgtactgtat gaaggcatca aggttggcaa agccaagctg ctcaaccagg    360

tactggtgaa cctgccaacc tccatcagcc agcagaccat cgcagagaca gacggggact    420

ctgcaggctc agattcattc cctgttggca gaacccacca caggtggtat ttgtgtcact    480

ttggccagtc tctaatccat gtcatccagg tggtcatcgg ctacttcatc atgctggccg    540

taatgtccta caacacctgg attttccttg gtgtggtctt gggctctgct gtgggctact    600

acctagctta cccacttctc agcacagctt agctggtgag gaacgtgcag gcactgaggc    660

tggagggaca tggagccccc tcttccagac actatacttc caactgccct ttcttctgat    720

ggctattcct ccaccttatt cccagcccct ggaaactttg agctgaagcc agcacttgct    780

ccctggagtt cggaagccat tgcagcaacc ttccttctca gccagcctac gtagggccca    840

ggcatggtct tgtgtcttaa gacagctgct gtgaccaaag ggagaatgga gataacaggg    900

gtggcagggt tactgagccc atgacaatgc ttctctgtga ctcaaaccag gaatttccaa    960

agatttcaag ccagggagaa gggttcttgg tgatgcaggg catggaacct ggacaccctc   1020

agctctcctg ctttgtgcct tatctacagg agcatcgccc attggacttc ctgacctctt   1080

ctgtctttga gggacagaga ccaagctaga tcctttttct cacctttctg cctttggaac   1140

acatgaagat catctcgtct atggatcatg ttgacaaact aagttttttt tatttttccc   1200

attgaactcc tagttggcaa ttttgcacat tcatacaaaa aaatttttaa tgaaatgatt   1260

tcattgattc atgatggatg gcagaaactg ctgagaccta tttccctttc ttggggagag   1320

aataagtgac agctgattaa aggcagagac acaggactgc tttcaggctc ctggtttatt   1380

ctctgataga ctgagctcct tccaccagaa ggcactgcct gcaggaagaa gatgatctga   1440

tggccgtggg tgtctgggaa gctcttcgtg gcctcaatgc cctcctttat cctcatcttt   1500

cttctatgca gaacaaaaag ctgcatctaa taatgttcaa tacttaatat tctctattta   1560

ttacttactg cttactcgta atgatctagt ggggaaacat gattcattca cttaaaatac   1620

tgattaagcc atgggcaggt actgactgaa gatgcaatcc aaccaaagcc attacatttt   1680

ttgagttaga tgggactctc tggatagttg aacctcttca ctttataaaa aaggaaagag   1740

agaaaatcac tgctgtatac taaatacctc acagattaga tgaaaagatg gttgtaagct   1800

ttgggaatta aaaacaaaca aatacatttt agtaaatata tatttttaaa tagtctatga   1860

ctgttctgtt ctcctaattc caacagaaag cacatgaacc cttg                    1904


<210>  2507
<211>  138
<212>  PRT
<213>  Homo sapiens

<400>  2507


Met Thr Ser Leu Ala Thr Gly Asp Gln Phe Asn Leu Gln Ser Leu Ser 
1               5                   10                  15      


Pro Ser Arg Gly Met Ala Leu Ser Val Leu Val Leu Leu Leu Leu Ala 
            20                  25                  30          


Val Leu Tyr Glu Gly Ile Lys Val Gly Lys Ala Lys Leu Leu Asn Gln 
        35                  40                  45              


Val Leu Val Asn Leu Pro Thr Ser Ile Ser Gln Gln Thr Ile Ala Glu 
    50                  55                  60                  


Thr Asp Gly Asp Ser Ala Gly Ser Asp Ser Phe Pro Val Gly Arg Thr 
65                  70                  75                  80  


His His Arg Trp Tyr Leu Cys His Phe Gly Gln Ser Leu Ile His Val 
                85                  90                  95      


Ile Gln Val Val Ile Gly Tyr Phe Ile Met Leu Ala Val Met Ser Tyr 
            100                 105                 110         


Asn Thr Trp Ile Phe Leu Gly Val Val Leu Gly Ser Ala Val Gly Tyr 
        115                 120                 125             


Tyr Leu Ala Tyr Pro Leu Leu Ser Thr Ala 
    130                 135             

<210>  2508
<211>  1760
<212>  DNA
<213>  Homo sapiens

<400>  2508
ggagacccga gcgagcagac gcggccctgg cgcccgccct gcgcactcac catggcgatg     60

catttcatct tctcagatac agcggtgctt ctgtttgatt tctggagtgt ccacagtcct    120

gctgggcaag aaactaaagc ccagagacag gaagagagac tcgtgcaggg tcacacagca    180

tggccctttc ggtgttggtg ctcctgcttc tggctgtact gtatgaaggc atcaaggttg    240

gcaaagccaa gctgctcaac caggtactgg tgaacctgcc aacctccatc agccagcaga    300

ccatcgcaga gacagacggg gactctgcag gctcagattc attccctgtt ggcagaaccc    360

accacaggtg gtatttgtgt cactttggcc agtctctaat ccatgtcatc caggtggtca    420

tcggctactt catcatgctg gccgtaatgt cctacaacac ctggattttc cttggtgtgg    480

tcttgggctc tgctgtgggc tactacctag cttacccact tctcagcaca gcttagctgg    540

tgaggaacgt gcaggcactg aggctggagg gacatggagc cccctcttcc agacactata    600

cttccaactg ccctttcttc tgatggctat tcctccacct tattcccagc ccctggaaac    660

tttgagctga agccagcact tgctccctgg agttcggaag ccattgcagc aaccttcctt    720

ctcagccagc ctacgtaggg cccaggcatg gtcttgtgtc ttaagacagc tgctgtgacc    780

aaagggagaa tggagataac aggggtggca gggttactga gcccatgaca atgcttctct    840

gtgactcaaa ccaggaattt ccaaagattt caagccaggg agaagggttc ttggtgatgc    900

agggcatgga acctggacac cctcagctct cctgctttgt gccttatcta caggagcatc    960

gcccattgga cttcctgacc tcttctgtct ttgagggaca gagaccaagc tagatccttt   1020

ttctcacctt tctgcctttg gaacacatga agatcatctc gtctatggat catgttgaca   1080

aactaagttt tttttatttt tcccattgaa ctcctagttg gcaattttgc acattcatac   1140

aaaaaaattt ttaatgaaat gatttcattg attcatgatg gatggcagaa actgctgaga   1200

cctatttccc tttcttgggg agagaataag tgacagctga ttaaaggcag agacacagga   1260

ctgctttcag gctcctggtt tattctctga tagactgagc tccttccacc agaaggcact   1320

gcctgcagga agaagatgat ctgatggccg tgggtgtctg ggaagctctt cgtggcctca   1380

atgccctcct ttatcctcat ctttcttcta tgcagaacaa aaagctgcat ctaataatgt   1440

tcaatactta atattctcta tttattactt actgcttact cgtaatgatc tagtggggaa   1500

acatgattca ttcacttaaa atactgatta agccatgggc aggtactgac tgaagatgca   1560

atccaaccaa agccattaca ttttttgagt tagatgggac tctctggata gttgaacctc   1620

ttcactttat aaaaaaggaa agagagaaaa tcactgctgt atactaaata cctcacagat   1680

tagatgaaaa gatggttgta agctttggga attaaaaaca aacaaataca ttttagtaaa   1740

tatatatttt taaatagtct                                               1760


<210>  2509
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  2509


Met Ala Leu Ser Val Leu Val Leu Leu Leu Leu Ala Val Leu Tyr Glu 
1               5                   10                  15      


Gly Ile Lys Val Gly Lys Ala Lys Leu Leu Asn Gln Val Leu Val Asn 
            20                  25                  30          


Leu Pro Thr Ser Ile Ser Gln Gln Thr Ile Ala Glu Thr Asp Gly Asp 
        35                  40                  45              


Ser Ala Gly Ser Asp Ser Phe Pro Val Gly Arg Thr His His Arg Trp 
    50                  55                  60                  


Tyr Leu Cys His Phe Gly Gln Ser Leu Ile His Val Ile Gln Val Val 
65                  70                  75                  80  


Ile Gly Tyr Phe Ile Met Leu Ala Val Met Ser Tyr Asn Thr Trp Ile 
                85                  90                  95      


Phe Leu Gly Val Val Leu Gly Ser Ala Val Gly Tyr Tyr Leu Ala Tyr 
            100                 105                 110         


Pro Leu Leu Ser Thr Ala 
        115             

<210>  2510
<211>  1808
<212>  DNA
<213>  Homo sapiens

<400>  2510
ggagacccga gcgagcagac gcggccctgg cgcccgccct gcgcactcac catggcgatg     60

catttcatct tctcagatac agcggtgctt ctgtttgatt tctggagtgt ccacagtcct    120

gctgggcaag aaactaaagc ccagagacag gaagagagac tcgtgcaggg tcacacagca    180

tggccctttc ggtgttggtg ctcctgcttc tggctgtact gtatgaaggc atcaaggttg    240

gcaaagccaa gctgctcaac caggtactgg tgaacctgcc aacctccatc agccagcaga    300

ccatcgcaga gacagacggg gactctgcag gctcagattc attccctgtt ggcagaaccc    360

accacaggtg gtatttgtgt cactttggcc agtctctaat ccatgtcatc caggtggtca    420

tcggctactt catcatgctg gccgtaatgt cctacaacac ctggattttc cttggtgtgg    480

tcttgggctc tgctgtgggc tactacctag cttacccact tctcagcaca gcttagctgg    540

tgaggaacgt gcaggcactg aggctggagg gacatggagc cccctcttcc agacactata    600

cttccaactg ccctttcttc tgatggctat tcctccacct tattcccagc ccctggaaac    660

tttgagctga agccagcact tgctccctgg agttcggaag ccattgcagc aaccttcctt    720

ctcagccagc ctacgtaggg cccaggcatg gtcttgtgtc ttaagacagc tgctgtgacc    780

aaagggagaa tggagataac aggggtggca gggttactga gcccatgaca atgcttctct    840

gtgactcaaa ccaggaattt ccaaagattt caagccaggg agaagggttc ttggtgatgc    900

agggcatgga acctggacac cctcagctct cctgctttgt gccttatcta caggagcatc    960

gcccattgga cttcctgacc tcttctgtct ttgagggaca gagaccaagc tagatccttt   1020

ttctcacctt tctgcctttg gaacacatga agatcatctc gtctatggat catgttgaca   1080

aactaagttt tttttatttt tcccattgaa ctcctagttg gcaattttgc acattcatac   1140

aaaaaaattt ttaatgaaat gatttcattg attcatgatg gatggcagaa actgctgaga   1200

cctatttccc tttcttgggg agagaataag tgacagctga ttaaaggcag agacacagga   1260

ctgctttcag gctcctggtt tattctctga tagactgagc tccttccacc agaaggcact   1320

gcctgcagga agaagatgat ctgatggccg tgggtgtctg ggaagctctt cgtggcctca   1380

atgccctcct ttatcctcat ctttcttcta tgcagaacaa aaagctgcat ctaataatgt   1440

tcaatactta atattctcta tttattactt actgcttact cgtaatgatc tagtggggaa   1500

acatgattca ttcacttaaa atactgatta agccatgggc aggtactgac tgaagatgca   1560

atccaaccaa agccattaca ttttttgagt tagatgggac tctctggata gttgaacctc   1620

ttcactttat aaaaaaggaa agagagaaaa tcactgctgt atactaaata cctcacagat   1680

tagatgaaaa gatggttgta agctttggga attaaaaaca aacaaataca ttttagtaaa   1740

tatatatttt taaatagtct atgactgttc tgttctccta attccaacag aaagcacatg   1800

aacccttg                                                            1808


<210>  2511
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  2511


Met Ala Leu Ser Val Leu Val Leu Leu Leu Leu Ala Val Leu Tyr Glu 
1               5                   10                  15      


Gly Ile Lys Val Gly Lys Ala Lys Leu Leu Asn Gln Val Leu Val Asn 
            20                  25                  30          


Leu Pro Thr Ser Ile Ser Gln Gln Thr Ile Ala Glu Thr Asp Gly Asp 
        35                  40                  45              


Ser Ala Gly Ser Asp Ser Phe Pro Val Gly Arg Thr His His Arg Trp 
    50                  55                  60                  


Tyr Leu Cys His Phe Gly Gln Ser Leu Ile His Val Ile Gln Val Val 
65                  70                  75                  80  


Ile Gly Tyr Phe Ile Met Leu Ala Val Met Ser Tyr Asn Thr Trp Ile 
                85                  90                  95      


Phe Leu Gly Val Val Leu Gly Ser Ala Val Gly Tyr Tyr Leu Ala Tyr 
            100                 105                 110         


Pro Leu Leu Ser Thr Ala 
        115             

<210>  2512
<211>  782
<212>  DNA
<213>  Homo sapiens

<400>  2512
ccgccctgcg cactcaccat ggcgatgcat ttcatcttct cagatacagc ggtgcttctg     60

tttgatttct ggagtgtcca cagtcctgct ggcatggccc tttcggtgtt ggtgctcctg    120

cttctggctg tactgtatga aggcatcaag gttggcaaag ccaagctgct caaccaggta    180

ctggtgaacc tgccaacctc catcagccag cagaccatcg cagagacaga cggggactct    240

gcaggctcag attcattccc tgttggcaga acccaccaca ggtacaggca gtgggtatgg    300

gaaaggggca gaagcctcac attcaccctg agagacaggc tggcccagac agcattagcc    360

ccacttcaca gagaggacag cgaggcccag ggaaggacca ggacttgcca aagtggctac    420

acatagccaa gtgaactaga gctcatgtct cctgatgccc aggccaaagc actctgtgaa    480

cagccagcca cttgagaggc tcagaaggct ttctttaggg aacagtgatc ttcaggtgca    540

ggcccctatc tagcaaatga ggtggccacc caccctcccc caaatctcac cagttccatg    600

ggtcactagg ctcccatatc caggagggga tctgcagctg tcctgaagca atgtatccca    660

cttggtggga ggaggatgac aagctctcct ctcctccctt cccactcgaa tcaggcaacc    720

atttagggtc cctgttctgc cctctgtcca gccccagcct cacctgtgct taataagcct    780

gc                                                                   782


<210>  2513
<211>  135
<212>  PRT
<213>  Homo sapiens

<400>  2513


Met Ala Met His Phe Ile Phe Ser Asp Thr Ala Val Leu Leu Phe Asp 
1               5                   10                  15      


Phe Trp Ser Val His Ser Pro Ala Gly Met Ala Leu Ser Val Leu Val 
            20                  25                  30          


Leu Leu Leu Leu Ala Val Leu Tyr Glu Gly Ile Lys Val Gly Lys Ala 
        35                  40                  45              


Lys Leu Leu Asn Gln Val Leu Val Asn Leu Pro Thr Ser Ile Ser Gln 
    50                  55                  60                  


Gln Thr Ile Ala Glu Thr Asp Gly Asp Ser Ala Gly Ser Asp Ser Phe 
65                  70                  75                  80  


Pro Val Gly Arg Thr His His Arg Tyr Arg Gln Trp Val Trp Glu Arg 
                85                  90                  95      


Gly Arg Ser Leu Thr Phe Thr Leu Arg Asp Arg Leu Ala Gln Thr Ala 
            100                 105                 110         


Leu Ala Pro Leu His Arg Glu Asp Ser Glu Ala Gln Gly Arg Thr Arg 
        115                 120                 125             


Thr Cys Gln Ser Gly Tyr Thr 
    130                 135 

<210>  2514
<211>  3264
<212>  DNA
<213>  Homo sapiens

<400>  2514
tgaggaggcc caggaatctg tacttttaat aaggccctgg agtctaagca gctgctgctg     60

tccctctaca ctaagccgct tgccagtgtg gagctcatga ttggcctgtg gtttcccagt    120

gattcacccg ggactgactc tgcctctgtg gatccggcta taacagcatc gtcatccaca    180

cctgtgatcc gctccagtgt cctccctccc accctatcct ctttgccttt tcatcctgtt    240

gtccgctgtt gtccctgggc tctggtctta ctgtcccatc cccagactgg tccttgtttg    300

tttcctttat ttaaggtgca ctcttcatct ttctcaggaa atatgggcca gctattggct    360

gaacatcctt cgggggctaa gcatgactat cctaattgca cagaggcttt ttctcataca    420

ttccttcctc tccccaattt cttcccatat tttgttccaa agtggccata tcagtttctt    480

ctgctgtttg catatcttcc tgaaatgtta aaacaaccga acgacagcac agccctcatc    540

tctgtctagt attgcacaag aaagtgggct gttctctgtg ttgtagcatc tgttttcctc    600

ttgccaaatg agggcctggt aagaagaccc aggatccagt cctgatgctg ccaccaactc    660

acagtgtgac cctgggcatg tcacagctgc cccttggact tccagtgctg ccctgagaag    720

ctgcattgag agcagttagg agcacagaat ctgaaaccag cccacccagg caaaattcta    780

gctagcaact tggcaagtta cttaaactct gtctgcctta gtagtctcat ctatgaaatg    840

gagctaagaa taataattcc cctcttgaaa ttgagtgagt taagacatat aacattttta    900

gaagagtgcc tggcacagaa taatcagtgt catttccctc ccagcatgaa aaaagagggt    960

tgctctaaat tagcacttcc tagaggatag tctatgagat tctttcccac agggcactca   1020

gcaagagaaa aaggggagga gagagttctg ggtacaggct tctggcagtg cagaaagcta   1080

ttaaacctta ttttgtctaa ttccagtctc tctcaaactc ccttgaccat agaatccatt   1140

tttcccagta cctcctagca tcctgtactt ctcccatgga acacttctga gaaacacccc   1200

tccagctttg acatgtatgg gaaaaaaagg cactggggtt attgagccct tactgtgtgt   1260

cactttgtgt ggatggcttt gcagagtttt cccccagctc ccctcggagg aaactgaggc   1320

cagagagagg ccctggttaa caaatgtgtt ttgttccaaa tcctggactc agactactat   1380

tctttactat ctcctttggt cctaactgtt gagaggggga ggattggaga cgactagaac   1440

atgcaaggcc tgtggtttag ggctgtcgtc tgcaagcaga agtttgtggc tctggtttcc   1500

aggaggctac aggacaccca catggcacag cttcctgaca aaatggcagc taatcaaatc   1560

tgcctacctt tccaccccca cactgacgtt tgcctccacc ggaactcctt ttctatgcat   1620

ttcatcttct cagatacagc ggtgcttctg tttgatttct ggagtgtcca cagtcctgct   1680

ggcatggccc tttcggtgtt ggtgctcctg cttctggctg tactgtatga aggcatcaag   1740

gttggcaaag ccaagctgct caaccaggta ctggtgaacc tgccaacctc catcagccag   1800

cagaccatcg cagagacaga cggggactct gcaggctcag attcattccc tgttggcaga   1860

acccaccaca ggtggtattt gtgtcacttt ggccagtctc taatccatgt catccaggtg   1920

gtcatcggct acttcatcat gctggccgta atgtcctaca acacctggat tttccttggt   1980

gtggtcttgg gctctgctgt gggctactac ctagcttacc cacttctcag cacagcttag   2040

ctggtgagga acgtgcaggc actgaggctg gagggacatg gagccccctc ttccagacac   2100

tatacttcca actgcccttt cttctgatgg ctattcctcc accttattcc cagcccctgg   2160

aaactttgag ctgaagccag cacttgctcc ctggagttcg gaagccattg cagcaacctt   2220

ccttctcagc cagcctacgt agggcccagg catggtcttg tgtcttaaga cagctgctgt   2280

gaccaaaggg agaatggaga taacaggggt ggcagggtta ctgagcccat gacaatgctt   2340

ctctgtgact caaaccagga atttccaaag atttcaagcc agggagaagg gttcttggtg   2400

atgcagggca tggaacctgg acaccctcag ctctcctgct ttgtgcctta tctacaggag   2460

catcgcccat tggacttcct gacctcttct gtctttgagg gacagagacc aagctagatc   2520

ctttttctca cctttctgcc tttggaacac atgaagatca tctcgtctat ggatcatgtt   2580

gacaaactaa gtttttttta tttttcccat tgaactccta gttggcaatt ttgcacattc   2640

atacaaaaaa atttttaatg aaatgatttc attgattcat gatggatggc agaaactgct   2700

gagacctatt tccctttctt ggggagagaa taagtgacag ctgattaaag gcagagacac   2760

aggactgctt tcaggctcct ggtttattct ctgatagact gagctccttc caccagaagg   2820

cactgcctgc aggaagaaga tgatctgatg gccgtgggtg tctgggaagc tcttcgtggc   2880

ctcaatgccc tcctttatcc tcatctttct tctatgcaga acaaaaagct gcatctaata   2940

atgttcaata cttaatattc tctatttatt acttactgct tactcgtaat gatctagtgg   3000

ggaaacatga ttcattcact taaaatactg attaagccat gggcaggtac tgactgaaga   3060

tgcaatccaa ccaaagccat tacatttttt gagttagatg ggactctctg gatagttgaa   3120

cctcttcact ttataaaaaa ggaaagagag aaaatcactg ctgtatacta aatacctcac   3180

agattagatg aaaagatggt tgtaagcttt gggaattaaa aacaaacaaa tacattttag   3240

taaatatata tttttaaata gtct                                          3264


<210>  2515
<211>  199
<212>  PRT
<213>  Homo sapiens

<400>  2515


Met Gln Gly Leu Trp Phe Arg Ala Val Val Cys Lys Gln Lys Phe Val 
1               5                   10                  15      


Ala Leu Val Ser Arg Arg Leu Gln Asp Thr His Met Ala Gln Leu Pro 
            20                  25                  30          


Asp Lys Met Ala Ala Asn Gln Ile Cys Leu Pro Phe His Pro His Thr 
        35                  40                  45              


Asp Val Cys Leu His Arg Asn Ser Phe Ser Met His Phe Ile Phe Ser 
    50                  55                  60                  


Asp Thr Ala Val Leu Leu Phe Asp Phe Trp Ser Val His Ser Pro Ala 
65                  70                  75                  80  


Gly Met Ala Leu Ser Val Leu Val Leu Leu Leu Leu Ala Val Leu Tyr 
                85                  90                  95      


Glu Gly Ile Lys Val Gly Lys Ala Lys Leu Leu Asn Gln Val Leu Val 
            100                 105                 110         


Asn Leu Pro Thr Ser Ile Ser Gln Gln Thr Ile Ala Glu Thr Asp Gly 
        115                 120                 125             


Asp Ser Ala Gly Ser Asp Ser Phe Pro Val Gly Arg Thr His His Arg 
    130                 135                 140                 


Trp Tyr Leu Cys His Phe Gly Gln Ser Leu Ile His Val Ile Gln Val 
145                 150                 155                 160 


Val Ile Gly Tyr Phe Ile Met Leu Ala Val Met Ser Tyr Asn Thr Trp 
                165                 170                 175     


Ile Phe Leu Gly Val Val Leu Gly Ser Ala Val Gly Tyr Tyr Leu Ala 
            180                 185                 190         


Tyr Pro Leu Leu Ser Thr Ala 
        195                 

<210>  2516
<211>  3863
<212>  DNA
<213>  Homo sapiens

<400>  2516
atcttggaaa cagtttttga agttggtaga gtctcgggcc cgcttaactg ctgaaagagt     60

aggaaggggt ccgtttcatt agcgcgttca accaaagagc gctgttaggt gagcaaaaac    120

aaaccagttg tgtctgagcc aacacccgtt tgtctatggg ttgtagcagt tggtccacct    180

aatcaaggaa gtgccgagag cacaggacat gaaaagacac agcgctaagg tttcctgcac    240

cacaaggttc ctttcactta aaaaaatttt tttttatatt acaccatctt tatttgtacc    300

ttaccgtcta aggctatcaa tcaaacttca gtaagaacag tttcagcatc aactaacgaa    360

cagtagccaa accagagagc agtcaaaagt gttttaaagg gagcagcatc agctgatgtt    420

ctgccaagtc tctgggtgtt caggaccatg gtcccccggc acttccaggc ccctgtgggc    480

tgcaggtgga tccccaggag ccaaagggcc gctcaggaaa gggtggaact tggcctcgca    540

atcagctggc ttctgcctat tatggtcatc ttctttccag aggtcttgct atctcagtgg    600

acgtggctgt catccagccg tcctgggctg ttttctcata gaagaggatc tccctctgaa    660

aactgtgtca tccttcaatt cctgggccaa gtctggggac acatcttttc ttaaagcttg    720

ctggtatgac gagcagttcc cattttcctg cactttacga agtctctgag gtgcaagcag    780

tagacatcct tctccatgga ctccccctga ggctgcttca tgtgttttca gggcagttca    840

ggcagatcgg aaaccactgg ctgcagcttc gggatgtccc tctccagctg tgcccttgaa    900

ccctgcagag agacctgctc gctgagcaga ccttgggctt gtgctgtgag ttctgtactc    960

ctttgggttt cttctcacaa tcgtatgtct gctttaccag tctttccctc gggacattcg   1020

aaggaagcac ctaaattacc attgtcatcc atgctttcag agggacttgc ggccacgatg   1080

ctgggggacc accctgttct gcttccctgt tcccctccac tgccaagtcc tcattttcca   1140

tgtcgtcttt cctggtgcag atgaagggtg ctcagcagag cgtgagccac cagggaagcc   1200

actcgcctac tccagttcga atattgggga cttgaggcca tcttgtcttt tttgtgtgtg   1260

tgtggcgtct gatttacaac ttcttggtcg ggcagctctg tgggttgctg atggtccatg   1320

ctgtcattca catcgtccgt ggtgtgcact ggaagatctc catgctgtga agcgtgcagg   1380

atgtgcttca catcagtcac ttggggaagt tcaggaggct gctttttcat gcttttttca   1440

gaagctcgcc taggttaggt cctgatcgga agacctgctc atttccatta gaaccttcaa   1500

gcagagtgtt tggagcaatc aaggactggc cccagcatgg ataacaggta gctaccactg   1560

gtgtgggctg ctggctgcat cttggcgcag gcctttctgt gggcctcacc ttagactgaa   1620

gccctttggg ccagcccttc cctccttctc actgcgtgtc gtctcctgac cagagaggcc   1680

atcacagcgg tgcacgccca gctcacccat agtatcccta gggtcactgg cactggtccc   1740

aggattctgt acatcactac ttactgctgc ccacaggtgg gccagcagca gttgaggagg   1800

catttcgtgg tgagcagcag gtccttcatg gctcttgagg gctccacagc tcttcctctt   1860

ttctctactg gtatgtgggt cacaactgac cactcagaac cctgcagagt gttccacctc   1920

taacacaaac aagggctcgc caaccagggc aaaccatcca ttatgctggg ggaggaaagg   1980

caccgcaaat tctagaaaac tgtgtccctg attttgctgt gcaaatataa agtgacatta   2040

cttaacacag tgccttggaa gaggggaaag agttcacggc agcccccagc tcaggccact   2100

gcaggtccca cctggcctta cagcatagct agagggtcaa agccagtcaa agccccgtgt   2160

ccacgcatga tcctctcagg gcagcgtgat ggcccgtccc tggtggggct cattaccctg   2220

atttcaagtt tccttctgct gcagggaagc ctggtcccgc ctacaaagag actgtctacc   2280

ttgctagatt gaactatagg actatgtttt cttcatctct gtaaccccag aagctctcca   2340

gagaccctta tacactaggg acatggtcat tgcttgtctt gttttcttgt tgactctact   2400

ctgacttagg gcacatcgct ttcccctcta gatctccata ttcagatctg tgaatgacag   2460

taagtgggtg aaggcccctc tagctttaaa acccctccaa tacagagagt acactgaaac   2520

cggaagcaga agctgagtgt ggtgagtgga gcattttccc tggcatgatg gaggggacct   2580

atggatctgg ctatgagggt ggcatctggc cacttgaatg gctctgcaga gctggaccct   2640

agttttcaaa tcagactcaa gaatgatctt tagtgtgggt ggttttgtgg ggcatatatt   2700

ttttgagacc ttgttattga cacaacagct tctgggaagt ctttttgaca gagagtatgc   2760

acaggtgcgg gctccatctg ctcggcagcc gctgtctggt gacggtgagc gctgagagct   2820

ggatggtcct gttagaaagg cagcatgcca gcctccggtg atgagcagag tgacccgacc   2880

ttgtctctcc ttccccatgg agcactgcag gctctttccc cagacctgct tctaggcttc   2940

ccttcacccg ctcccaccag gcagctgagg ccactttagg attccatttt tagttgtact   3000

ttttttttaa ttgatcattt tgtgagcatt tttctctcta atgcaacaga actagcacaa   3060

gtccttaaag atgtaggatc tctcagctcc cacaaaaaca aagataatgg cctatgtaat   3120

tctctacata tttaaattgt tagctctaaa aatagattca gagaaagggt ggacacatgt   3180

tccaattttc tcataacagt cctgggttgt gcctgttatc ctggcatagt tattaatcct   3240

gtcccctttc actctcagac tctcctggtt tggaggataa tttcattcta ttcaaagagg   3300

aaatctacaa aaaggtgtca tcatctaacc tgtattcata taaacatttt ccagtctcac   3360

ggttctgtgt acctctccaa acccctcaat cttctaatca ttttgtgtat tatttatagg   3420

aaaagagcac cagctaaaat atcttgccct tggatttctt cagccagctg ctgaagtaat   3480

ttgtcttagt ctttactgaa gactgaattg tatcattaag actttcttct aagtcctgtt   3540

attttgactt tttgactcac tctgtgccct ctgatacata aagtagcaat aatttgtaca   3600

atgagccatt gtatttgttc acgagaaatt cttcctgttc ctcacatttc tattcatttt   3660

cctaaaggta tgtatttgaa aacttgaaaa attgcctggc ccagttatag tttaatggga   3720

gcatttaaac atacttttcc tacaaagctt atcagttagt tacttaacct ttatgaatag   3780

gttaaatatt ttccacagta tttatataaa tatgatactt ggtttcaagt taaatctaat   3840

aaaaaggaag ttattcttga ctt                                           3863


<210>  2517
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  2517


Met Lys Arg His Ser Ala Lys Val Ser Cys Thr Thr Arg Phe Leu Ser 
1               5                   10                  15      


Leu Lys Lys Ile Phe Phe Tyr Ile Thr Pro Ser Leu Phe Val Pro Tyr 
            20                  25                  30          


Arg Leu Arg Leu Ser Ile Lys Leu Gln 
        35                  40      

<210>  2518
<211>  538
<212>  DNA
<213>  Homo sapiens

<400>  2518
atttgtacct taccgtctaa ggctatcaat caaacttcag taagaacagt ttcagcatca     60

actaacgaac agtagccaaa ccagagagca gtcaaaagtg ttttaaaggg agcagcatca    120

gctgatgttc tgccaagtct ctgggtgttc aggaccaccc tgttctgctt ccctgttccc    180

ctccactgcc aagtcctcat tttccatgtc gtctttcctg gtgcagatga agggtgctca    240

gcagagcgtg agccaccagg gaagccactc gcctactcca gttcgaatat tggggacttg    300

aggccatctt gtcttttttg tgtgtgtgtg gcgtctgatt tacaacttct tggtcgggca    360

gctctgtggg ttgctgatgg tccatgctgt cattcacatc gtccgtggtg tgcactggaa    420

gatctccatg ctgtgaagcg tgcaggatgt gcttcacatc agtcacttgg ggaagttcag    480

gaggctgctt tttcatgctt ttttcagaag ctcgcctagg ttaggtcctg atcggaag      538


<210>  2519
<211>  58
<212>  PRT
<213>  Homo sapiens

<400>  2519


Met Phe Cys Gln Val Ser Gly Cys Ser Gly Pro Pro Cys Ser Ala Ser 
1               5                   10                  15      


Leu Phe Pro Ser Thr Ala Lys Ser Ser Phe Ser Met Ser Ser Phe Leu 
            20                  25                  30          


Val Gln Met Lys Gly Ala Gln Gln Ser Val Ser His Gln Gly Ser His 
        35                  40                  45              


Ser Pro Thr Pro Val Arg Ile Leu Gly Thr 
    50                  55              

<210>  2520
<211>  735
<212>  DNA
<213>  Homo sapiens

<400>  2520
agacggcaag ggatgtgtag ctttttcaat cctggccata acattcttct tcatgctctt     60

ctcaatgtcc tttctccttt cattaggtaa aatggagatg atccccaggg ccatcttgga    120

aacagttttt gaagttggta gagtctcggg cccgcttaac tgctgaaaga gtaggaaggg    180

gtccgtttca ttagcgcgtt caaccaaaga gcgctgttag gtttcctgca ccacaaggtt    240

cctttcactt aaaaaaattt ttttttatat tacaccatct ttatttgtac cttaccgtct    300

aaggctatca atcaaacttc agtaagaaca gtttcagcat caactaacga acagtagcca    360

aaccagagag cagtcaaaag tgttttaaag ggagcagcat cagctgatgt tctgccaagt    420

ctctgggtgt tcaggaccat ggtcccccgg cacttccagg cccctgtggg ctgcaggtgg    480

atccccagga gccaaagggc cgctcaggaa agggtggaac ttggcctcgc aatcagctgg    540

cttctgccta ttatggtcat cttctttcca gaggtcttgc tatctcagtg gacgtggctg    600

tcatccagcc gtcctgggct gttttctcat agaagaggat ctccctctga aaactgtgtc    660

atccttcaat tcctgggcca agtctgggga cacatctttt cttaaagctt gctggtatga    720

cgagcagttc ccatt                                                     735


<210>  2521
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  2521


Met Phe Cys Gln Val Ser Gly Cys Ser Gly Pro Trp Ser Pro Gly Thr 
1               5                   10                  15      


Ser Arg Pro Leu Trp Ala Ala Gly Gly Ser Pro Gly Ala Lys Gly Pro 
            20                  25                  30          


Leu Arg Lys Gly Trp Asn Leu Ala Ser Gln Ser Ala Gly Phe Cys Leu 
        35                  40                  45              


Leu Trp Ser Ser Ser Phe Gln Arg Ser Cys Tyr Leu Ser Gly Arg Gly 
    50                  55                  60                  


Cys His Pro Ala Val Leu Gly Cys Phe Leu Ile Glu Glu Asp Leu Pro 
65                  70                  75                  80  


Leu Lys Thr Val Ser Ser Phe Asn Ser Trp Ala Lys Ser Gly Asp Thr 
                85                  90                  95      


Ser Phe Leu Lys Ala Cys Trp Tyr Asp Glu Gln Phe 
            100                 105             

<210>  2522
<211>  555
<212>  DNA
<213>  Homo sapiens

<400>  2522
agtctcgggc ccgcttaact gctgaaagag taggaagggg tccgtttcat tagcgcgttc     60

aaccaaagag cgctgttagg tgagcaaaaa caaaccagtt gtgtctgagc caacacccgt    120

ttgtctatgg gttgtagcag ttggtccacc taatcaagga agtgccgaga gcacaggaca    180

tgaaaagaca cagcgctaag agtctcactc tgttgcccag gctggagtgc agcagcaaga    240

tcataactca gggcaaactt gacctcccag gctcaagcga tcttctggcc tcagcctccc    300

aggtttcctg caccacaagg ttcctttcac ttaaaaaaat ttttttttat attacaccat    360

ctttatttgt accttaccgt ctaaggctat caatcaaact tcagtaagaa cagtttcagc    420

atcaactaac gaacagtagc caaaccagag agcagtcaaa agtgttttaa agggagcagc    480

atcagctgat gttctgccaa gtctctgggt gttcaggacc atggtccccc ggcacttcca    540

ggcccctgtg ggctg                                                     555


<210>  2523
<211>  75
<212>  PRT
<213>  Homo sapiens

<400>  2523


Met Lys Arg His Ser Ala Lys Ser Leu Thr Leu Leu Pro Arg Leu Glu 
1               5                   10                  15      


Cys Ser Ser Lys Ile Ile Thr Gln Gly Lys Leu Asp Leu Pro Gly Ser 
            20                  25                  30          


Ser Asp Leu Leu Ala Ser Ala Ser Gln Val Ser Cys Thr Thr Arg Phe 
        35                  40                  45              


Leu Ser Leu Lys Lys Ile Phe Phe Tyr Ile Thr Pro Ser Leu Phe Val 
    50                  55                  60                  


Pro Tyr Arg Leu Arg Leu Ser Ile Lys Leu Gln 
65                  70                  75  

<210>  2524
<211>  406
<212>  DNA
<213>  Homo sapiens

<400>  2524
ggaaactcct attgtgatct taagggctgt aacccagaga atctggttct tcctggagta     60

tttcagcagg gatcagctta aataggtcta cttgaagttc acaactgcca aaaccgcgtg    120

ttcagactga aaggctggga gcatttcaga cgcatttatg aacttccacc aagatgatcc    180

ggcaggctga aatcgcaggg agagcgtctg ttcaacaaac cctttcttct tgattgaatt    240

agtgttaccc actaacagga tgaggaattc ccactccaca agctgacttt ttttcctctt    300

tccacctccc gcctccctcc attaaaatgt aaacttgatt cctgtgtcct ttgccggagc    360

ctggcttccc tgtaagccca tcataaacat cttggtagaa atgcaa                   406


<210>  2525
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  2525


Gln Asp Glu Glu Phe Pro Leu His Lys Leu Thr Phe Phe Pro Leu Ser 
1               5                   10                  15      


Thr Ser Arg Leu Pro Pro Leu Lys Cys Lys Leu Asp Ser Cys Val Leu 
            20                  25                  30          


Cys Arg Ser Leu Ala Ser Leu 
        35                  

<210>  2526
<211>  253
<212>  DNA
<213>  Homo sapiens

<400>  2526
acagcctgca agcagcagct ggtgcccagc gtgcaaatgt atcactacca gcaccagagg     60

ttaacagata ctacagctgg agctgcagaa agagcctcct gaggagctgg actctgcaga    120

tgagaatgaa agcagtgact ttatggtgta cagtctggac cttcaaattg gagggggtga    180

ggagaaccct aaagcccagg catcgatggg gaattctgga gacaaaagct aattaaagtt    240

catttcaaac ctg                                                       253


<210>  2527
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  2527


Met Arg Met Lys Ala Val Thr Leu Trp Cys Thr Val Trp Thr Phe Lys 
1               5                   10                  15      


Leu Glu Gly Val Arg Arg Thr Leu Lys Pro Arg His Arg Trp Gly Ile 
            20                  25                  30          


Leu Glu Thr Lys Ala Asn 
        35              

<210>  2528
<211>  6639
<212>  DNA
<213>  Homo sapiens

<400>  2528
ccgggcggtt ggcgtcctct gcggctcctg ccaggggcgg gcttttcaaa tcttcccttt     60

gaaggagtgg cgacggcccg gacagttcgc gttggagatg gaggggccga gcctgagggg    120

tcctgcgctc cgcctggcgg ggcttcccac ccagcaggac tgcaacattc aagaaaaaat    180

agacttagaa attcgaatgc gagaaggaat atggaaactc ctttctctga gcactcagaa    240

agatcaagtt ttacatgcag ttaagaatct catggtgtgc aatgctcgac taatggccta    300

tacatcggag ctacagaaat tagaagaaca gattgcaaat cagactggaa gatgtgatgt    360

gaaatttgaa agtaaagaac gaacagcatg taaaggaaag attgccatat cagatattcg    420

aataccacta atgtggaaag actctgatca cttcagcaat aaagaacgat cacgacgcta    480

tgccattttt tgtttattca aaatgggagc taatgtgttt gatactgatg tggtgaatgt    540

ggataaaaca atcacagata tatgttttga aaatgtaacc atatttaatg aagcagggcc    600

agactttcag ataaaggtgg aagtgtatag ttgctgtaca gaagaatctt ctataaccaa    660

cacaccaaaa aagctagcta agaaactcaa gacatctata agtaaagcta caggaaagaa    720

aataagttca gtgcttcaag aagaggatga tgaaatgtgc ttgctcctca gctctgctgt    780

ttttggtgta aagtataatt tgctagctca cactacccta accttggaaa gtgctgagga    840

tagtttcaag acccataatc tgtctattaa tggaaatgag gagtcttcat tttggcttcc    900

cctgtatggc aacatgtgct gccgactagt tgcccagcca gcttgtatgg ctgaggatgc    960

atttgcagga tttcttaatc agcagcaaat ggtagaaggt ctgattagtt ggagaaggtt   1020

gtattgtgtt ttgcgaggag gtaaactcta ttgtttttac agtccagagg aaattgaagc   1080

taaagtggaa ccagctttgg tagtacccat taacaaggaa accagaatcc gggcaatgga   1140

taaggatgcc aagaaaagaa tccataattt ctctgtcatc aatcctgttc ctggacaagc   1200

tataactcag atttttgcag ttgacaatag agaagatctt cagaagtgga tggaagcctt   1260

ctggcagcat ttctttgatc ttagccaatg gaagcactgt tgtgaagaac ttatgaaaat   1320

tgagattatg tcaccacgga aaccaccttt gttcttgaca aaagaggcaa cctcagtcta   1380

ccatgatatg agcattgatt cacctatgaa acttgaaagt ttaacggata taatacaaaa   1440

aaaaattgaa gagacaaatg ggcagttcct tattggtcag catgaagaat ccttaccacc   1500

tccttgggcc acactctttg atggtaacca tcaaatggtc atccagaaaa aggtactgta   1560

tcctgcaagt gagccattac atgatgaaaa agggaaaaag agacaagctc cccttcctcc   1620

ttctgataaa cttccattca gcttaaaatc acagagtaac acagatcaat tggttaagga   1680

caactgggga aaaacaagtg tatctcagac atcgtctttg gataccaaac tatcaactct   1740

aatgcatcac ttacagaaac caatggctgc tcctcgaaaa cttctgcctg ccaggagaaa   1800

tagattaagt gatggtgagc acacagacac taaaaccaat tttgaagcca agccagtgcc   1860

agctccaagg cagaaatcca tcaaagacat tctggaccct agatcatggc tgcaggcaca   1920

agtatagaaa actcttaatg ataaaacatt taacaaaatc tataactgtg aagcttaatt   1980

cagaggcatt atagaataat gtgtaattat ataggtaaat atagtgattt ataccaataa   2040

ttaataagct attaggtata gaaaaacatt ttataatgaa gaagtggatt tctcttttac   2100

tcctgatttg cagaatgtaa gtgatttctc cagcagtgtg caagaggcag tttctagaca   2160

atatcctaat tgttggaagg gttaatttat tcctgaatta gtaccaggca gtgaataagc   2220

cctaggcaga ataaagcatt aaaatttctt ttggggagag actgtctagt aatttaaaat   2280

gtgttaaata tgaaccatat tctcattgtg agaattttaa tactaatgga atgtttcaaa   2340

ggttttattc aaaccacaaa ttatagaatc cacccaagaa aattttctta gcattctgga   2400

attctcatct aatggttcac tggctctcat ctattgttta actcactagt ttataggcct   2460

gaccttttaa attcctggga taaattttag aatattaaat tcttcatctt taaagggaat   2520

ttgtaatgtg ctattcaaac ttgtttcctt gatgagccct gaaatactgt tgacattaac   2580

tttcataaat gaagcataac acttactagt ttagagaaat ggtagatgaa atgctcttta   2640

cattcaattt tctgtgtgtg gtgctaattt ccattgtgac tttggaattt agggaagtga   2700

gtagctgatc aacaccttaa aattcattta atacttattt aaaaagaaga tgagagattc   2760

aaaaatatca gaaaagttgg ccatggtaaa taattttcag aattcttttt taaaatttta   2820

attagatttc cttttcctag taagagttga tgtctgctag tggtattttt cattaaatgt   2880

catattctta caacagtgac attggaatca tttccatagg aggtaatttc catagcaact   2940

aatcatagtg acccaaacag gattataaag tcaagtgagg aataaatagc agaaaaatac   3000

cttaaaggaa caaaaaatcc attttttata ataatgcttt ttgtaaacaa gagcagaaca   3060

gttttaaaaa tctaattaga atttccaaat aaaacagttt ccataaggtg tcagcaacag   3120

cactaaaaat ctcaaatcac actgaaccct aaatgtcatt gcaagaaata aaaatttaag   3180

aattaaattg ctgccctgtg tataatctct tgagatcttt ttaaagctag caagaactct   3240

atttggatca gaactacatt attacaaaac aaaatgaaca cttgaccaaa aaaccacatt   3300

aatttaaatg gagcctttca ttattttcag atagcggggt cttttccatt tatagagaat   3360

gatgtaactg ccaggacact tttgtgtttg cccaggactc ctagtaagaa ttgaatcttg   3420

agggagtaat gataacaaaa ggtttcttgt gactggtaac atcaggacag acagagtttt   3480

tggtgagaag aaagtactat atgcctgctt gatagcatgt agagatcatc acatgtatgg   3540

aaaccttaaa aagtaaactt attttttcta actagaaggc tctcataagt ttctgttatg   3600

attgccattt caataaatga cattaaaaat ctaaaggata ttattgtttg aatttttggg   3660

ttatttttta aaacttcatt gctgtttttg acagcatttg tgactgtcat tgccactaaa   3720

ttattgagct agaagatgct gcagggaaaa ttgttttgaa gctggcatct aagcattctt   3780

ttttttttcc tagttgatgc cttcctttat tacaaatcag tattaaaact tccagattat   3840

attcttgtca tttttcctca tgcagataac agcaggaagg acttaaggtg tataagaaaa   3900

agaaagtatt catacagaaa ttacctagca gttgtgccct cagagtagaa ctttgaaaca   3960

ggactgaagc cctttttacc tagaaccatt taaaagcctg agcaaggacc accaccccct   4020

ccccaccaaa ttattcggtc tctttctggg gggcccagct tactgtatgt tacaagtctt   4080

tgaaatgggt ctggtgtctt cagctcctga aatgctaatt taccccttac ctaaggagtg   4140

tagttataat acagagttgg tttccttcct tccttccttc cttccttcct tccttccttc   4200

cttccttcct tccttccttc cttccttcat tccctctgtc cgtctctcct tccctccttc   4260

cctccttcct tcctttttgt ctttgtttct ttctctggcc ccctgtcctc tctctctgtc   4320

tcatcccctt ttcccacttt ccttctgtct ctccttcctc ccttccttta cagtttaaaa   4380

aaaaaatcta aaaatagtta agcactgtgt caaagagtgt ttcaaaagaa ttgtttgttt   4440

tctcatttct taaaccagaa gtttatgaca aataaatatg ccatgtaata tgaaagctgc   4500

ttcagctttt tatgagcttt cacattcctt gtttgtcctt ttaatttgtt tcttgatata   4560

tgaagactat aaacttgaaa caaagagtta gctgtcagct cttgataata taattgggga   4620

aacagaatag atattttatg atatgataat tctgatgatc taaagataat gtcttagaca   4680

attaccttta catttcaagc tctgggatat aaattacgta gtcagcatta agatagtatt   4740

atttttaatt gctactaagt ggtaactttt gtattttaat atcttgcaag ggcaaagaag   4800

gcatttttaa aattctaaat gcacacctcc taaggtaaat agtctttcaa aaatatcagg   4860

cgtgccaact cttgctgagt tttgttaaat cctccttaac tgtctgcagt gccccctgac   4920

ttcttttaaa tggatgtgaa tatatgtgga aaactaaatc catttattat aaatgcctta   4980

tctttaccct ttgggatctt actaaatgca ttttacctgc tactatttat taaaaatgga   5040

agctgtcttg aattagagat acctcacgta aggtaggtta agcagtcaag tatttcttta   5100

ggcttatgtt cagcacctca gccccctact gagaagttaa ttaattcagt ccaaaatgaa   5160

attatagggc agtttggtgc aatttatgtt aaatgccatt tgaatgtaat cacctgtgtt   5220

accacgaatg aggcacaact atactacatg gacagagtac tgcattgcac catgagcaag   5280

aactgctctg caagaaaaat atctgtccct gtggtctgaa tttatcaaaa ctcattttct   5340

tgttaaagag tgaattattg aatagtaatt aaactttaac tgatgaccat ttatattcta   5400

gtagccatct tcactgttag tcttaaatta taatgtaaag ttgacatttt ccccttacat   5460

ttcaaaggca tcactatttt taaatgttta catatgttta catgtttgtg tgcaactgct   5520

tcattgctat taatagttaa atgaaatctg catattctgg atcatagatg ttcttagtta   5580

actctgggaa agatgttacc tttgggtttt taaaagacaa gtcatcattt gaaaatatat   5640

tagggtgtgt tgattttctg acatgcttgt gtaattggct ttgtttataa tttttatttt   5700

ttaatatggg tcagactttt ggattaaaaa gtattatatc atggacatac attttttaaa   5760

gtaccaaagg tatttggtaa gcgagcccaa gtcatgtaat tgaaacttct gtacattaaa   5820

agaactgatt catgaagacg ttttctaact ttttctcttt aagtgctcct ctagactaga   5880

ctgattgaag tagacagtgt ggtggaatca gtttaatcag aaaaagacat accaagtagc   5940

tggtgctaat tattataaga ctaacattct gataagccat ggtataatta acattattaa   6000

aatgtttaca tataatcctt cttaaagtat actcttttaa aaatccattg acataacctt   6060

acttttagtt tagtgatcca gaatttcccc agagcttaag ccactgcagt aaattaggta   6120

cgtaggatat tcagtcgcta ctagccacaa ggagtctcct tattttaatg tacctccctc   6180

agtactttat tcctgcagag cgcctcagag tgggggagag aaatgagcaa tcctggctca   6240

gttggattat ttcagcattt tatttctaaa tctgtagtgt gatcagaaat atttaaaatt   6300

aaaaaaatac tttacagaga gaggcctact aatcaatgtg cttagagaaa caaactacct   6360

ttacattcaa ttaacaacaa aaaaagttac agaaatttta acaaacattt ttctttatct   6420

gagtatggga gaaaatacta atgctgacac gtttaataat tagaaaagat cattccagat   6480

cttatggaaa attgtgtttt aaattccagc agtttgctct tgagacatgg taatctctta   6540

atgtaactac taaaggagag gtagattgaa aagatcttgt atatacataa ttatgtcaga   6600

tggttcaaga tatcaaaata aattgttttg ttgaaaatg                          6639


<210>  2529
<211>  609
<212>  PRT
<213>  Homo sapiens

<400>  2529


Met Glu Gly Pro Ser Leu Arg Gly Pro Ala Leu Arg Leu Ala Gly Leu 
1               5                   10                  15      


Pro Thr Gln Gln Asp Cys Asn Ile Gln Glu Lys Ile Asp Leu Glu Ile 
            20                  25                  30          


Arg Met Arg Glu Gly Ile Trp Lys Leu Leu Ser Leu Ser Thr Gln Lys 
        35                  40                  45              


Asp Gln Val Leu His Ala Val Lys Asn Leu Met Val Cys Asn Ala Arg 
    50                  55                  60                  


Leu Met Ala Tyr Thr Ser Glu Leu Gln Lys Leu Glu Glu Gln Ile Ala 
65                  70                  75                  80  


Asn Gln Thr Gly Arg Cys Asp Val Lys Phe Glu Ser Lys Glu Arg Thr 
                85                  90                  95      


Ala Cys Lys Gly Lys Ile Ala Ile Ser Asp Ile Arg Ile Pro Leu Met 
            100                 105                 110         


Trp Lys Asp Ser Asp His Phe Ser Asn Lys Glu Arg Ser Arg Arg Tyr 
        115                 120                 125             


Ala Ile Phe Cys Leu Phe Lys Met Gly Ala Asn Val Phe Asp Thr Asp 
    130                 135                 140                 


Val Val Asn Val Asp Lys Thr Ile Thr Asp Ile Cys Phe Glu Asn Val 
145                 150                 155                 160 


Thr Ile Phe Asn Glu Ala Gly Pro Asp Phe Gln Ile Lys Val Glu Val 
                165                 170                 175     


Tyr Ser Cys Cys Thr Glu Glu Ser Ser Ile Thr Asn Thr Pro Lys Lys 
            180                 185                 190         


Leu Ala Lys Lys Leu Lys Thr Ser Ile Ser Lys Ala Thr Gly Lys Lys 
        195                 200                 205             


Ile Ser Ser Val Leu Gln Glu Glu Asp Asp Glu Met Cys Leu Leu Leu 
    210                 215                 220                 


Ser Ser Ala Val Phe Gly Val Lys Tyr Asn Leu Leu Ala His Thr Thr 
225                 230                 235                 240 


Leu Thr Leu Glu Ser Ala Glu Asp Ser Phe Lys Thr His Asn Leu Ser 
                245                 250                 255     


Ile Asn Gly Asn Glu Glu Ser Ser Phe Trp Leu Pro Leu Tyr Gly Asn 
            260                 265                 270         


Met Cys Cys Arg Leu Val Ala Gln Pro Ala Cys Met Ala Glu Asp Ala 
        275                 280                 285             


Phe Ala Gly Phe Leu Asn Gln Gln Gln Met Val Glu Gly Leu Ile Ser 
    290                 295                 300                 


Trp Arg Arg Leu Tyr Cys Val Leu Arg Gly Gly Lys Leu Tyr Cys Phe 
305                 310                 315                 320 


Tyr Ser Pro Glu Glu Ile Glu Ala Lys Val Glu Pro Ala Leu Val Val 
                325                 330                 335     


Pro Ile Asn Lys Glu Thr Arg Ile Arg Ala Met Asp Lys Asp Ala Lys 
            340                 345                 350         


Lys Arg Ile His Asn Phe Ser Val Ile Asn Pro Val Pro Gly Gln Ala 
        355                 360                 365             


Ile Thr Gln Ile Phe Ala Val Asp Asn Arg Glu Asp Leu Gln Lys Trp 
    370                 375                 380                 


Met Glu Ala Phe Trp Gln His Phe Phe Asp Leu Ser Gln Trp Lys His 
385                 390                 395                 400 


Cys Cys Glu Glu Leu Met Lys Ile Glu Ile Met Ser Pro Arg Lys Pro 
                405                 410                 415     


Pro Leu Phe Leu Thr Lys Glu Ala Thr Ser Val Tyr His Asp Met Ser 
            420                 425                 430         


Ile Asp Ser Pro Met Lys Leu Glu Ser Leu Thr Asp Ile Ile Gln Lys 
        435                 440                 445             


Lys Ile Glu Glu Thr Asn Gly Gln Phe Leu Ile Gly Gln His Glu Glu 
    450                 455                 460                 


Ser Leu Pro Pro Pro Trp Ala Thr Leu Phe Asp Gly Asn His Gln Met 
465                 470                 475                 480 


Val Ile Gln Lys Lys Val Leu Tyr Pro Ala Ser Glu Pro Leu His Asp 
                485                 490                 495     


Glu Lys Gly Lys Lys Arg Gln Ala Pro Leu Pro Pro Ser Asp Lys Leu 
            500                 505                 510         


Pro Phe Ser Leu Lys Ser Gln Ser Asn Thr Asp Gln Leu Val Lys Asp 
        515                 520                 525             


Asn Trp Gly Lys Thr Ser Val Ser Gln Thr Ser Ser Leu Asp Thr Lys 
    530                 535                 540                 


Leu Ser Thr Leu Met His His Leu Gln Lys Pro Met Ala Ala Pro Arg 
545                 550                 555                 560 


Lys Leu Leu Pro Ala Arg Arg Asn Arg Leu Ser Asp Gly Glu His Thr 
                565                 570                 575     


Asp Thr Lys Thr Asn Phe Glu Ala Lys Pro Val Pro Ala Pro Arg Gln 
            580                 585                 590         


Lys Ser Ile Lys Asp Ile Leu Asp Pro Arg Ser Trp Leu Gln Ala Gln 
        595                 600                 605             


Val 
    

<210>  2530
<211>  1943
<212>  DNA
<213>  Homo sapiens

<400>  2530
ggacagttcg cgttggagat ggaggggccg agcctgaggg gtcctgcgct ccgcctggcg     60

gggcttccca cccagcagga ctgcaacatt caagaaaaaa tagacttaga aattcgaatg    120

cgagaaggaa tatggaaact cctttctctg agcactcaga aagatcaagt tttacatgca    180

gttaagaatc tcatggtgtg caatgctcga ctaatggcct atacatcgga gctacagaaa    240

ttagaagaac agattgcaaa tcagactgga agatgatatt cgaataccac taatgtggaa    300

agactctgat cacttcagca ataaagaacg atcacgacgc tatgccattt tttgtttatt    360

caaaatggga gctaatgtgt ttgatactga tgtggtgaat gtggataaaa caatcacaga    420

tatatgtttt gaaaatgtaa ccatattgta agtatttttt aatcttcaga gaataaaaat    480

aatttaaaat tcttcttttt taaaagaaag ttcttattat tggttctttg gattcatttt    540

atgtttaaat gtttaagtga tctttaaatg tttaatatga ttttaaaaat cattttgttc    600

agaagaagtc catttctcta tctgcagttt tctgatgtga aataaaaatg gaaatcttgt    660

aattactatt agcagtaaat atttgactta ttagatatga cccattttta aattgttaat    720

aaatatagtt cagttattaa caaagctatg catacaacag aatatcctgt aatgttattt    780

gatatagaga gaatttaagc ataaaacagg atttttatct catgtaggat atttggttgc    840

agaaatacta aaatagtata gcaactttat ttacaagata gtcctgaagt acatgctata    900

taggaagagc actttgaaat tttggggtgt tctttttctt atggtgcact tctttcatgt    960

acttcaaagc aataaaaaaa aatgggtgat ctcagggctg tttttattgt ccctgctctt   1020

ttacaggctc attttattgt ggtcataata cagaacaaga aggaactcct tgggtagcca   1080

tagaaatcat ttttaactaa catagttttt cctgccctcc ttcaaaggtt ctatgtgcct   1140

aaatcagtgt gggatttgta ttttagactt ttaaagacac gatctttaga tctaaatgtt   1200

aatagctact aactattaat ataaaaatcc atgtgcatgg tttttgccat tttcagctat   1260

ggagctagac aggtgagatt ttagaggcct agttttgcca ctcacataac attaaaaaaa   1320

cctatagtaa accatatttt gtagcttctg gtccagtgtc tcatagtaat agtatagcct   1380

ggaaaaataa aatgcattgt tctgagttat aagtagtaat tcaggccttc ttacaagctg   1440

tattgaacca aaggaattta tttaggatcc aaaacatatc cccaaatgct tatataattg   1500

aggctaaaaa aattactttt ttcttggtta tctgaataca tttatttcca ttatcaacta   1560

ttgctagtga actttttttt ctgccaaaat taccagttga tgggcccttt tcttcacatc   1620

attttgctat tgtttgtttt gatcatggag acaaaaatca gacttttttt tccagggaaa   1680

gaacaataga agttactgag gaagacaaca catgatttat aattttttga gaattctgta   1740

aatattttaa attgtactaa aaataactgc tgacaaatgt tctacatgtt gaaaaatgtg   1800

ctttttgtta tgatgattgt ttttaataag tattcaatat ttatgaatct ctggtttttc   1860

tctaaatatt gacatttgtt agtcattacc aggaatactg catgtttaaa agttgccaaa   1920

taataaacta taaaaatagc tgg                                           1943


<210>  2531
<211>  85
<212>  PRT
<213>  Homo sapiens

<400>  2531


Met Glu Gly Pro Ser Leu Arg Gly Pro Ala Leu Arg Leu Ala Gly Leu 
1               5                   10                  15      


Pro Thr Gln Gln Asp Cys Asn Ile Gln Glu Lys Ile Asp Leu Glu Ile 
            20                  25                  30          


Arg Met Arg Glu Gly Ile Trp Lys Leu Leu Ser Leu Ser Thr Gln Lys 
        35                  40                  45              


Asp Gln Val Leu His Ala Val Lys Asn Leu Met Val Cys Asn Ala Arg 
    50                  55                  60                  


Leu Met Ala Tyr Thr Ser Glu Leu Gln Lys Leu Glu Glu Gln Ile Ala 
65                  70                  75                  80  


Asn Gln Thr Gly Arg 
                85  

<210>  2532
<211>  2081
<212>  DNA
<213>  Homo sapiens

<400>  2532
ccgggcggtt ggcgtcctct gcggctcctg ccaggggcgg gcttttcaaa tcttcccttt     60

gaaggagtgg cgacggcccg gacagttcgc gttggagatg gaggggccga gcctgagggg    120

tcctgcgctc cgcctggcgg ggcttcccac ccagcaggac tgcaacattc aagaaaaaat    180

agacttagaa attcgaatgc gagaaggaat atggaaactc ctttctctga gcactcagaa    240

agatcaagtt ttacatgcag ttaagaatct catggtgtgc aatgctcgac taatggccta    300

tacatcggag ctacagaaat tagaagaaca gattgcaaat cagactggaa gatgtgatgt    360

gaaatttgaa agtaaagaac gaacagcatg taaaggaaag attgccatat cagatattcg    420

aataccacta atgtggaaag actctgatca cttcagcaat aaagaacgat cacgacgcta    480

tgccattttt tgtttattca aaatgggagc taatgtgttt gatactgatg tggtgaatgt    540

ggataaaaca atcacagata tatgttttga aaatgtaacc atattgtaag tattttttaa    600

tcttcagaga ataaaaataa tttaaaattc ttctttttta aaagaaagtt cttattattg    660

gttctttgga ttcattttat gtttaaatgt ttaagtgatc tttaaatgtt taatatgatt    720

ttaaaaatca ttttgttcag aagaagtcca tttctctatc tgcagttttc tgatgtgaaa    780

taaaaatgga aatcttgtaa ttactattag cagtaaatat ttgacttatt agatatgacc    840

catttttaaa ttgttaataa atatagttca gttattaaca aagctatgca tacaacagaa    900

tatcctgtaa tgttatttga tatagagaga atttaagcat aaaacaggat ttttatctca    960

tgtaggatat ttggttgcag aaatactaaa atagtatagc aactttattt acaagatagt   1020

cctgaagtac atgctatata ggaagagcac tttgaaattt tggggtgttc tttttcttat   1080

ggtgcacttc tttcatgtac ttcaaagcaa taaaaaaaaa tgggtgatct cagggctgtt   1140

tttattgtcc ctgctctttt acaggctcat tttattgtgg tcataataca gaacaagaag   1200

gaactccttg ggtagccata gaaatcattt ttaactaaca tagtttttcc tgccctcctt   1260

caaaggttct atgtgcctaa atcagtgtgg gatttgtatt ttagactttt aaagacacga   1320

tctttagatc taaatgttaa tagctactaa ctattaatat aaaaatccat gtgcatggtt   1380

tttgccattt tcagctatgg agctagacag gtgagatttt agaggcctag ttttgccact   1440

cacataacat taaaaaaacc tatagtaaac catattttgt agcttctggt ccagtgtctc   1500

atagtaatag tatagcctgg aaaaataaaa tgcattgttc tgagttataa gtagtaattc   1560

aggccttctt acaagctgta ttgaaccaaa ggaatttatt taggatccaa aacatatccc   1620

caaatgctta tataattgag gctaaaaaaa ttactttttt cttggttatc tgaatacatt   1680

tatttccatt atcaactatt gctagtgaac ttttttttct gccaaaatta ccagttgatg   1740

ggcccttttc ttcacatcat tttgctattg tttgttttga tcatggagac aaaaatcaga   1800

cttttttttc cagggaaaga acaatagaag ttactgagga agacaacaca tgatttataa   1860

ttttttgaga attctgtaaa tattttaaat tgtactaaaa ataactgctg acaaatgttc   1920

tacatgttga aaaatgtgct ttttgttatg atgattgttt ttaataagta ttcaatattt   1980

atgaatctct ggtttttctc taaatattga catttgttag tcattaccag gaatactgca   2040

tgtttaaaag ttgccaaata ataaactata aaaatagctg g                       2081


<210>  2533
<211>  163
<212>  PRT
<213>  Homo sapiens

<400>  2533


Met Glu Gly Pro Ser Leu Arg Gly Pro Ala Leu Arg Leu Ala Gly Leu 
1               5                   10                  15      


Pro Thr Gln Gln Asp Cys Asn Ile Gln Glu Lys Ile Asp Leu Glu Ile 
            20                  25                  30          


Arg Met Arg Glu Gly Ile Trp Lys Leu Leu Ser Leu Ser Thr Gln Lys 
        35                  40                  45              


Asp Gln Val Leu His Ala Val Lys Asn Leu Met Val Cys Asn Ala Arg 
    50                  55                  60                  


Leu Met Ala Tyr Thr Ser Glu Leu Gln Lys Leu Glu Glu Gln Ile Ala 
65                  70                  75                  80  


Asn Gln Thr Gly Arg Cys Asp Val Lys Phe Glu Ser Lys Glu Arg Thr 
                85                  90                  95      


Ala Cys Lys Gly Lys Ile Ala Ile Ser Asp Ile Arg Ile Pro Leu Met 
            100                 105                 110         


Trp Lys Asp Ser Asp His Phe Ser Asn Lys Glu Arg Ser Arg Arg Tyr 
        115                 120                 125             


Ala Ile Phe Cys Leu Phe Lys Met Gly Ala Asn Val Phe Asp Thr Asp 
    130                 135                 140                 


Val Val Asn Val Asp Lys Thr Ile Thr Asp Ile Cys Phe Glu Asn Val 
145                 150                 155                 160 


Thr Ile Leu 
            

<210>  2534
<211>  739
<212>  DNA
<213>  Homo sapiens

<400>  2534
gcaacttccg gcggcgggag ctgcagagcg caaggcgcgc ccactgcgcg tgcgcttcgg     60

cccggctcct cctgcgcccc cggcccctgc gactgggact tggtacggcc gggcggttgg    120

cgtcctctgc ggctcctgcc aggggcgggc ttttcaaatc ttccctttga aggagtggcg    180

acggcccgga cagttcgcgt tggagatgga ggggccgagc ctgaggggtc ctgcgctccg    240

cctggcgggg cttcccaccc agcaggactg caacattcaa gaaaaaatag acttagaaat    300

tcgaatgcga gaaggaatat ggaaactcct ttctctgagc actcagaaag atcaagtttt    360

acatgcagtt aagaatctca tggtgtgcaa tgctcgacta atggcctata catcggagct    420

acagaaatta gaagaacaga ttgcaaatca gactggaaga tgtgatgtga aatttgaaag    480

taaagaacga acagcatgta aaggaaagat tgccatatca gatattcgaa taccactaat    540

gtggaaagac tctgatcact tcagcaataa agaacgatca cgacgctatg ccattttttg    600

tttattcaaa atgggagcta atgtgtttga tactgatgtg gtgaatgtgg ataaaacaat    660

cacagatata tgttttgaaa atgtaaccat attgtaagta ttttttaatc ttcagagaat    720

aaaaataatt taaaattct                                                 739


<210>  2535
<211>  163
<212>  PRT
<213>  Homo sapiens

<400>  2535


Met Glu Gly Pro Ser Leu Arg Gly Pro Ala Leu Arg Leu Ala Gly Leu 
1               5                   10                  15      


Pro Thr Gln Gln Asp Cys Asn Ile Gln Glu Lys Ile Asp Leu Glu Ile 
            20                  25                  30          


Arg Met Arg Glu Gly Ile Trp Lys Leu Leu Ser Leu Ser Thr Gln Lys 
        35                  40                  45              


Asp Gln Val Leu His Ala Val Lys Asn Leu Met Val Cys Asn Ala Arg 
    50                  55                  60                  


Leu Met Ala Tyr Thr Ser Glu Leu Gln Lys Leu Glu Glu Gln Ile Ala 
65                  70                  75                  80  


Asn Gln Thr Gly Arg Cys Asp Val Lys Phe Glu Ser Lys Glu Arg Thr 
                85                  90                  95      


Ala Cys Lys Gly Lys Ile Ala Ile Ser Asp Ile Arg Ile Pro Leu Met 
            100                 105                 110         


Trp Lys Asp Ser Asp His Phe Ser Asn Lys Glu Arg Ser Arg Arg Tyr 
        115                 120                 125             


Ala Ile Phe Cys Leu Phe Lys Met Gly Ala Asn Val Phe Asp Thr Asp 
    130                 135                 140                 


Val Val Asn Val Asp Lys Thr Ile Thr Asp Ile Cys Phe Glu Asn Val 
145                 150                 155                 160 


Thr Ile Leu 
            

<210>  2536
<211>  2934
<212>  DNA
<213>  Homo sapiens

<400>  2536
gcacatgatc tcttgcctgc tgacatgtaa gagatgactt tgcttctcct tcgccttctg     60

ccatgactat gaggcctccc cagtcatgtg aaccgacttt tagagtaatg caacagaagg    120

cttttgagga aagcagatat ccctggcagg agtcctttga gaatgttgct gtgtgcctgc    180

cattacgctg cccgaggtgt ggagaccata ccagatttag aagcttgtca tccttgaggg    240

cccatctgga gttcagtcac agctacgaag aaagaaccct cttgacaaaa tgcagtctct    300

ttccatccct caaagacaca gacctagtca cttcctcaga actcctgaaa ccgggaaaat    360

tgcagagcag tggcaacgtg gtaaagcaga aaccgagcta tgttaacttg tacagcattt    420

cacatgaaca ttccaaggac aggaagccat ttgaggtggt ggcagagagg cctgtgtcct    480

atgtgcagac ctacactgcc atggacctcc atgcagactc gctggatggg acacggtcgg    540

gtcctggact gcccacctca gacaccaaag cttctttcga ggcacatgtc agagaaaaat    600

tcaatcgaat ggttgaggct gtggatagga ccattgagaa gagaattgat aaactcacca    660

aagagttggc ccagaaaact gcggaactgt tggaagttcg ggcagctttt gtgcagctga    720

ctcagaaaaa gcaggaagtt cagagacgag agcgggcctt aaacagacag gtggacgtgg    780

ccgtggaaat gatagctgta ctgaggcaac gcctgacgga atctgaggag gagcttctta    840

ggaaagaaga agaagttgtc acattcaacc atttcctgga agcggcagct gagaaggagg    900

ttcaagggaa agcccggctc caggacttta ttgagaatct gttacagcgg gtagaactgg    960

cggagaagca gcttgagtac tatcagagcc agcaggcctc tggctttgtc cgtgatctca   1020

gcgggcacgt gcttacagac atctcctcaa ataggaagcc caaatgccta agccgagggc   1080

acccgcattc ggtatgtaac caccctgatc tcaaggccca tttccaccca aagggaagga   1140

accacctgaa aaaggccaag gatgacagag ccagcatgca gcctgccaag gccattcacg   1200

aacaggctga gtcctcaaga gacctctgca gacctccaaa gaaaggggag ctcctggggt   1260

ttggccgcaa aggcaacatc aggcccaaaa tggctaaaaa aaagccaaca gccattgtga   1320

acatcatcta aaagggtggg tggtgctgga ccaatcatcg ctgggctttg gggaacgttg   1380

ttccaggagc caacagtaat gtctttctgg aaacattcca tagtaagaca cattggaaaa   1440

gccaagggca taacacaggc aagcacctca attaaccaga gcttagcaaa tgggaatctt   1500

agtgaaccag aattttatta taaccccctt ttagaagctt gcaaattaca gaaagaataa   1560

aaaaattaaa tcaatcttaa agctctaact tctaaagtaa ctggcccagt ctccagtaat   1620

cttggcatct gggcttctat gcagtggtca ctaattttca ggaccaaggc cacacaaaat   1680

gtcaggccta gggagaaaat tcatctgtgc ccactgctct ccaaagtgcg aggcaaggaa   1740

tggcagtgta aagttctgtt aatagcagta aaatgaaaat atttgtgttt gtgtataacc   1800

ttcccctcag ctaatttgaa agcctccaaa ataaggattc ccattccccg agtattctgg   1860

ttaatcaaga tttcaatttc tgggttgctc aagggactcg ttcagtcaga cttcagttct   1920

cattccgaca gggtgtcttt cagttcgttt gtttgattga ggttttttgg tggcctagat   1980

gcatgtttat tcagattttg gtacacctct gccgtcttct ttggctgagt attctgcacc   2040

cacagaccat gctgccagcc tctatcttaa tagctgcttc tgtggatatg gctggggagc   2100

gaagtaaaat cctcttttga ttagcaccca gcatgggctg ggtggctagg tggttggaat   2160

gacagtggac tgcacgcttg gtgcatcgtg catcgtgacc atcctggaag cactgcgggt   2220

gtcgccaagc cctttcctaa gacctgcttc ccggccagtg tcagtggccc tctctctctc   2280

tgctatgggc atgactttct cttcgctggc ttaacttttc cactgggtgg ttcactttgc   2340

ctcctgctgc ttctgtgccc tgttaagggc ttcaggtatc tttcaaccaa gtatctggag   2400

tgttcactct atgttgcatt ctaaagtaat ttctgaaata aacaatgcat gtaggagcca   2460

gaatctgaca ctgtcttccc ctccttccct ccctaaaatg gctttagttt ccacaaagag   2520

ctgttaagaa tttcctgctg tatgattttc ctcaagaatg aatttccatg ttattttttc   2580

cttaaattta gcaatatcat caggtctctt gcagagttta caagtgctga cattcttctg   2640

aaaacaggaa taattttgtc cacaaatata tacatatata catatatata acacatacaa   2700

aatatatatg ttaagtatat taataattta tttttaaata ctcatggaga aagtgtgtgt   2760

ttgtggtggg tggtttttaa actatatatg tttgttcatg taaactgaat tctcttattt   2820

aaaaaatcaa aactgtaacg taattaacat tggcagaatt atgattgtta ctgcaataag   2880

catcaaatta gcagcgcatt aaaaatagga aataaagcag ttgcttaaaa tgcc         2934


<210>  2537
<211>  422
<212>  PRT
<213>  Homo sapiens

<400>  2537


Met Thr Met Arg Pro Pro Gln Ser Cys Glu Pro Thr Phe Arg Val Met 
1               5                   10                  15      


Gln Gln Lys Ala Phe Glu Glu Ser Arg Tyr Pro Trp Gln Glu Ser Phe 
            20                  25                  30          


Glu Asn Val Ala Val Cys Leu Pro Leu Arg Cys Pro Arg Cys Gly Asp 
        35                  40                  45              


His Thr Arg Phe Arg Ser Leu Ser Ser Leu Arg Ala His Leu Glu Phe 
    50                  55                  60                  


Ser His Ser Tyr Glu Glu Arg Thr Leu Leu Thr Lys Cys Ser Leu Phe 
65                  70                  75                  80  


Pro Ser Leu Lys Asp Thr Asp Leu Val Thr Ser Ser Glu Leu Leu Lys 
                85                  90                  95      


Pro Gly Lys Leu Gln Ser Ser Gly Asn Val Val Lys Gln Lys Pro Ser 
            100                 105                 110         


Tyr Val Asn Leu Tyr Ser Ile Ser His Glu His Ser Lys Asp Arg Lys 
        115                 120                 125             


Pro Phe Glu Val Val Ala Glu Arg Pro Val Ser Tyr Val Gln Thr Tyr 
    130                 135                 140                 


Thr Ala Met Asp Leu His Ala Asp Ser Leu Asp Gly Thr Arg Ser Gly 
145                 150                 155                 160 


Pro Gly Leu Pro Thr Ser Asp Thr Lys Ala Ser Phe Glu Ala His Val 
                165                 170                 175     


Arg Glu Lys Phe Asn Arg Met Val Glu Ala Val Asp Arg Thr Ile Glu 
            180                 185                 190         


Lys Arg Ile Asp Lys Leu Thr Lys Glu Leu Ala Gln Lys Thr Ala Glu 
        195                 200                 205             


Leu Leu Glu Val Arg Ala Ala Phe Val Gln Leu Thr Gln Lys Lys Gln 
    210                 215                 220                 


Glu Val Gln Arg Arg Glu Arg Ala Leu Asn Arg Gln Val Asp Val Ala 
225                 230                 235                 240 


Val Glu Met Ile Ala Val Leu Arg Gln Arg Leu Thr Glu Ser Glu Glu 
                245                 250                 255     


Glu Leu Leu Arg Lys Glu Glu Glu Val Val Thr Phe Asn His Phe Leu 
            260                 265                 270         


Glu Ala Ala Ala Glu Lys Glu Val Gln Gly Lys Ala Arg Leu Gln Asp 
        275                 280                 285             


Phe Ile Glu Asn Leu Leu Gln Arg Val Glu Leu Ala Glu Lys Gln Leu 
    290                 295                 300                 


Glu Tyr Tyr Gln Ser Gln Gln Ala Ser Gly Phe Val Arg Asp Leu Ser 
305                 310                 315                 320 


Gly His Val Leu Thr Asp Ile Ser Ser Asn Arg Lys Pro Lys Cys Leu 
                325                 330                 335     


Ser Arg Gly His Pro His Ser Val Cys Asn His Pro Asp Leu Lys Ala 
            340                 345                 350         


His Phe His Pro Lys Gly Arg Asn His Leu Lys Lys Ala Lys Asp Asp 
        355                 360                 365             


Arg Ala Ser Met Gln Pro Ala Lys Ala Ile His Glu Gln Ala Glu Ser 
    370                 375                 380                 


Ser Arg Asp Leu Cys Arg Pro Pro Lys Lys Gly Glu Leu Leu Gly Phe 
385                 390                 395                 400 


Gly Arg Lys Gly Asn Ile Arg Pro Lys Met Ala Lys Lys Lys Pro Thr 
                405                 410                 415     


Ala Ile Val Asn Ile Ile 
            420         

<210>  2538
<211>  2500
<212>  DNA
<213>  Homo sapiens

<400>  2538
aggcgctgga ggtgcgcgtc actgtccgcc gccgtgtccg cggctgcgcc agacagtgta     60

gaacctgcgg cctcgatgtc cttctcccgt gccctattgt gggctcggct cccggcgggg    120

cgccaggctg gccaccgggc agccatctgc tctgcccttc gtccccactt tgggcccttt    180

cccggggttc tggggcaagt ttctgtcctt gccaccgcct cctcctctgc ctccggtggc    240

tccaaaatac caaacacgtc cttgttcgtg cccctgactg tgaaacctca gggccccagc    300

gccgacggcg acgtcggggc cgagctaacc cggcctctgg acaagaatga agtaaagaag    360

gtcttagaca aattttacaa gaggaaagaa attcagaaac tgggtgctga ttatggactt    420

gatgctcgtc tcttccacca agctttcata agctttagaa attatattat gcagtctcat    480

tccctggatg tggacattca cattgttttg aatgatattt gcttcggtgc agctcatgcg    540

gatgatttat tcccattttt cttgagacat gccaaacaaa tatttcctgt gttggactgt    600

aaggatgatc tacgtaaaat cagtgactta agaataccac ctaactggta cccagatgct    660

agagccatgc agcggaagat aatatttcat tcaggcccca caaacagtgg aaagacttat    720

cacgcaatcc agaaatactt ctcagcaaag tctggagtgt attgtggccc tctaaaatta    780

ctggcacatg agatcttcga aaagagtaat gctgctggtg tgccatgtga cttggtgaca    840

ggtgaagagc gtgtgacagt tcagccaaat gggaaacagg cttcacatgt ttcttgtaca    900

gttgagatgt gcagtgttac aactccttat gaagtggctg taattgatga aattcaaatg    960

attagagatc cagccagagg atgggcctgg accagagcac ttctaggact gtgtgctgaa   1020

gaggttcatt tgtgtggaga acctgctgct attgacctgg tgatggagct tatgtacaca   1080

acgggggagg aagtggaggt tcgagactat aagaggctta cccccatttc tgtgctggac   1140

catgcactag aatctttaga taaccttcgg cctggggact gcattgtctg ttttagcaag   1200

aatgatattt attctgtgag tcggcagatt gaaattcggg gattagaatc agctgttata   1260

tatggcagtc tcccacctgg gaccaaactt gctcaagcaa aaaagtttaa tgatcccaat   1320

gacccatgca aaatcttggt tgctacagat gcaattggca tgggacttaa tttgagcata   1380

aggagaatta ttttttactc ccttataaag cccagtatca atgaaaaggg agagagagaa   1440

ctagaaccaa tcacaacctc tcaagccctg cagattgctg gcagagctgg cagattcagc   1500

tcacggttta aagaaggaga ggttacaaca atgaatcatg aagatctcag tttattaaag   1560

gaaattttga agaggcctgt ggatcctata agggcagctg gtcttcatcc aactgctgag   1620

cagattgaaa tgtttgccta ccatctccct gatgcaacac tgtccaatct cattgatatt   1680

tttgtagact tttcacaagt tgatgggcag tattttgtct gcaatatgga tgattttaaa   1740

ttttctgcag agttgatcca gcatattcca ctaagtctgc gagtgaggta tgttttctgc   1800

acagctccta tcaacaagaa gcagcctttt gtgtgttctt cactgttaca gtttgccagg   1860

cagtatagca ggaatgagcc cctgaccttt gcatggttac gccgatacat caaatggcct   1920

ttacttccac ctaagaatat taaagacctc atggatcttg aagctgtcca cgatgtcttg   1980

gatctttact tgtggctaag ctaccgattt atggatatgt ttccagatgc cagccttatt   2040

cgagatctcc agaaagaact agatggtatt atccaagatg gtgtgcacaa tatcactaaa   2100

ttgattaaaa tgtctgagac gcataagctg ttgaatttgg agggctttcc atcagggagc   2160

cagtcacgat tgtcaggaac cttaaagagc caagctagaa ggacacgcgg caccaaagct   2220

ctagggagta aagctactga gccacccagc cccgatgcag gagagctgtc ccttgcttcc   2280

agattggtgc agcaaggact cctcactcca gacatgctga aacagctaga aaaagagtgg   2340

atgacacaac aaactgaaca caacaaagaa aaaacagagt ctgggactca tccaaaaggg   2400

acgagaagaa agaagaagga acctgattcg gactagtttt ctgttcctgt tttttttttt   2460

ttatttaatt ttgcaaataa aaatttattt tgaatccttt                         2500


<210>  2539
<211>  786
<212>  PRT
<213>  Homo sapiens

<400>  2539


Met Ser Phe Ser Arg Ala Leu Leu Trp Ala Arg Leu Pro Ala Gly Arg 
1               5                   10                  15      


Gln Ala Gly His Arg Ala Ala Ile Cys Ser Ala Leu Arg Pro His Phe 
            20                  25                  30          


Gly Pro Phe Pro Gly Val Leu Gly Gln Val Ser Val Leu Ala Thr Ala 
        35                  40                  45              


Ser Ser Ser Ala Ser Gly Gly Ser Lys Ile Pro Asn Thr Ser Leu Phe 
    50                  55                  60                  


Val Pro Leu Thr Val Lys Pro Gln Gly Pro Ser Ala Asp Gly Asp Val 
65                  70                  75                  80  


Gly Ala Glu Leu Thr Arg Pro Leu Asp Lys Asn Glu Val Lys Lys Val 
                85                  90                  95      


Leu Asp Lys Phe Tyr Lys Arg Lys Glu Ile Gln Lys Leu Gly Ala Asp 
            100                 105                 110         


Tyr Gly Leu Asp Ala Arg Leu Phe His Gln Ala Phe Ile Ser Phe Arg 
        115                 120                 125             


Asn Tyr Ile Met Gln Ser His Ser Leu Asp Val Asp Ile His Ile Val 
    130                 135                 140                 


Leu Asn Asp Ile Cys Phe Gly Ala Ala His Ala Asp Asp Leu Phe Pro 
145                 150                 155                 160 


Phe Phe Leu Arg His Ala Lys Gln Ile Phe Pro Val Leu Asp Cys Lys 
                165                 170                 175     


Asp Asp Leu Arg Lys Ile Ser Asp Leu Arg Ile Pro Pro Asn Trp Tyr 
            180                 185                 190         


Pro Asp Ala Arg Ala Met Gln Arg Lys Ile Ile Phe His Ser Gly Pro 
        195                 200                 205             


Thr Asn Ser Gly Lys Thr Tyr His Ala Ile Gln Lys Tyr Phe Ser Ala 
    210                 215                 220                 


Lys Ser Gly Val Tyr Cys Gly Pro Leu Lys Leu Leu Ala His Glu Ile 
225                 230                 235                 240 


Phe Glu Lys Ser Asn Ala Ala Gly Val Pro Cys Asp Leu Val Thr Gly 
                245                 250                 255     


Glu Glu Arg Val Thr Val Gln Pro Asn Gly Lys Gln Ala Ser His Val 
            260                 265                 270         


Ser Cys Thr Val Glu Met Cys Ser Val Thr Thr Pro Tyr Glu Val Ala 
        275                 280                 285             


Val Ile Asp Glu Ile Gln Met Ile Arg Asp Pro Ala Arg Gly Trp Ala 
    290                 295                 300                 


Trp Thr Arg Ala Leu Leu Gly Leu Cys Ala Glu Glu Val His Leu Cys 
305                 310                 315                 320 


Gly Glu Pro Ala Ala Ile Asp Leu Val Met Glu Leu Met Tyr Thr Thr 
                325                 330                 335     


Gly Glu Glu Val Glu Val Arg Asp Tyr Lys Arg Leu Thr Pro Ile Ser 
            340                 345                 350         


Val Leu Asp His Ala Leu Glu Ser Leu Asp Asn Leu Arg Pro Gly Asp 
        355                 360                 365             


Cys Ile Val Cys Phe Ser Lys Asn Asp Ile Tyr Ser Val Ser Arg Gln 
    370                 375                 380                 


Ile Glu Ile Arg Gly Leu Glu Ser Ala Val Ile Tyr Gly Ser Leu Pro 
385                 390                 395                 400 


Pro Gly Thr Lys Leu Ala Gln Ala Lys Lys Phe Asn Asp Pro Asn Asp 
                405                 410                 415     


Pro Cys Lys Ile Leu Val Ala Thr Asp Ala Ile Gly Met Gly Leu Asn 
            420                 425                 430         


Leu Ser Ile Arg Arg Ile Ile Phe Tyr Ser Leu Ile Lys Pro Ser Ile 
        435                 440                 445             


Asn Glu Lys Gly Glu Arg Glu Leu Glu Pro Ile Thr Thr Ser Gln Ala 
    450                 455                 460                 


Leu Gln Ile Ala Gly Arg Ala Gly Arg Phe Ser Ser Arg Phe Lys Glu 
465                 470                 475                 480 


Gly Glu Val Thr Thr Met Asn His Glu Asp Leu Ser Leu Leu Lys Glu 
                485                 490                 495     


Ile Leu Lys Arg Pro Val Asp Pro Ile Arg Ala Ala Gly Leu His Pro 
            500                 505                 510         


Thr Ala Glu Gln Ile Glu Met Phe Ala Tyr His Leu Pro Asp Ala Thr 
        515                 520                 525             


Leu Ser Asn Leu Ile Asp Ile Phe Val Asp Phe Ser Gln Val Asp Gly 
    530                 535                 540                 


Gln Tyr Phe Val Cys Asn Met Asp Asp Phe Lys Phe Ser Ala Glu Leu 
545                 550                 555                 560 


Ile Gln His Ile Pro Leu Ser Leu Arg Val Arg Tyr Val Phe Cys Thr 
                565                 570                 575     


Ala Pro Ile Asn Lys Lys Gln Pro Phe Val Cys Ser Ser Leu Leu Gln 
            580                 585                 590         


Phe Ala Arg Gln Tyr Ser Arg Asn Glu Pro Leu Thr Phe Ala Trp Leu 
        595                 600                 605             


Arg Arg Tyr Ile Lys Trp Pro Leu Leu Pro Pro Lys Asn Ile Lys Asp 
    610                 615                 620                 


Leu Met Asp Leu Glu Ala Val His Asp Val Leu Asp Leu Tyr Leu Trp 
625                 630                 635                 640 


Leu Ser Tyr Arg Phe Met Asp Met Phe Pro Asp Ala Ser Leu Ile Arg 
                645                 650                 655     


Asp Leu Gln Lys Glu Leu Asp Gly Ile Ile Gln Asp Gly Val His Asn 
            660                 665                 670         


Ile Thr Lys Leu Ile Lys Met Ser Glu Thr His Lys Leu Leu Asn Leu 
        675                 680                 685             


Glu Gly Phe Pro Ser Gly Ser Gln Ser Arg Leu Ser Gly Thr Leu Lys 
    690                 695                 700                 


Ser Gln Ala Arg Arg Thr Arg Gly Thr Lys Ala Leu Gly Ser Lys Ala 
705                 710                 715                 720 


Thr Glu Pro Pro Ser Pro Asp Ala Gly Glu Leu Ser Leu Ala Ser Arg 
                725                 730                 735     


Leu Val Gln Gln Gly Leu Leu Thr Pro Asp Met Leu Lys Gln Leu Glu 
            740                 745                 750         


Lys Glu Trp Met Thr Gln Gln Thr Glu His Asn Lys Glu Lys Thr Glu 
        755                 760                 765             


Ser Gly Thr His Pro Lys Gly Thr Arg Arg Lys Lys Lys Glu Pro Asp 
    770                 775                 780                 


Ser Asp 
785     

<210>  2540
<211>  1933
<212>  DNA
<213>  Homo sapiens

<400>  2540
aaatgtgagc acagcccttg cggtggtatg agaggtggcc tcgacggtgg agcccatcct     60

gggatgccat cactgggaag agagagctgg tgctcccagc ctggggaaac tcggataaag    120

gtgacaggag gctccatccc aggcacattc ccggtgaaag ggcattttat ccagggtgaa    180

gaacacgtgc tactgtctac agagtgcgtc cacgtacgtc acctcttctc atcgccacag    240

catccctttg aggcagccac gtaaggccaa agttcttgtc cccagagcca tgaaaaatac    300

acactgaaaa cctcccagtt ctcctgtgga tgaacaatct gcagattttt agaaattgtt    360

ccagggtctc agtagtaacc cttgcaggca ccgctggccc aggatctgga caattctaga    420

ggcaggaagc acagagacga agaaggggac tcactgcctg accgcagaga aacgagctgt    480

gccttttgac cagatggaga aaccaaggca cagagcccaa ctgggacgca gtgaaatcga    540

gatttgaacg caggcagtct agctgcagag ttcttgcttg cccgctgtgc tacactggct    600

aggctggaaa caaggcacgg ggagacttgg ggcctcagct ggaaaaatgg ccctaagctc    660

tttctaacac agtggaaagt gcacaggccc tggggtccta ctttggcttt tcttaaactg    720

caggtaaagg tccaagtcta tattcatatc tgtaaaagct tcatagctat gtcagtggtc    780

acagtgagaa agaaagcaaa ttatcacaca aggaaaggca tgtggtctac agtgggcaca    840

ctagaagcat ctcctgaagc tcagcctttc cctggctggg gacccctctt cgctcaccca    900

acttggtctc ttgggataag aaaatgtgtg cagacctttc agtccactca gtaaggcatg    960

atcctaaacc attagaaagt acctgttcca tgtactggaa ttaaaggaac agttgggaat   1020

tttatggaaa ttctattcct gttactaaag aaaacagctc ttgaattctg ccctgtattc   1080

tttttaatgg taagtccaaa gttaagtcgt cataacataa atcagtgtga cctgctggta   1140

ttccacttgc tgcaaaagaa tcagaaactg tgtgggagag caaacttcca taataagaaa   1200

accaatgtag agacttccaa acgctgccag tggttacagt cacaatggtg tctctatcgg   1260

agcagccaca aatgaagcag aaatgctaac ctcagcaagt ttcaaaagaa tgctgctaat   1320

catttttaca ggtttattct gaaccgaaga caaggaatgc tcaggaagaa attctgacat   1380

gatttctaaa tcacaactgt acattaaggg tcatatttgc aaaacaccta tcaaggaaag   1440

aaaagccata caagaaaatg cagttcatgt gacttttaac atttttcaga ataattacaa   1500

tctcaattgc acaaaataac caacttttca aagcaaatga gacttctggt taaacacggc   1560

attaacctac aaggacaaaa agaaaggaaa cagtgactga taagagatct taacataatt   1620

ctggaagaca ggaagctcac ggaagtaatt gcttagtaga gcaaacactg aaacctgagt   1680

gcccgcagag ggtgactcgg gtgagaaagg agctgtgacg tttgtaaaac tctaaaatgc   1740

tcaggaatca gaggtctggg gcaagacata gagccaaaaa caagagattg gttaaaaagc   1800

tatataaaaa agcttggcca ggcacggtgg ctcacccctg taatcccagc attttgggag   1860

gccaaggcag gtggatcatt tgaggtcagg agttcgagac cagcctggcc caggtggtac   1920

ccccatccct act                                                      1933


<210>  2541
<211>  78
<212>  PRT
<213>  Homo sapiens

<400>  2541


Met Arg Gly Gly Leu Asp Gly Gly Ala His Pro Gly Met Pro Ser Leu 
1               5                   10                  15      


Gly Arg Glu Ser Trp Cys Ser Gln Pro Gly Glu Thr Arg Ile Lys Val 
            20                  25                  30          


Thr Gly Gly Ser Ile Pro Gly Thr Phe Pro Val Lys Gly His Phe Ile 
        35                  40                  45              


Gln Gly Glu Glu His Val Leu Leu Ser Thr Glu Cys Val His Val Arg 
    50                  55                  60                  


His Leu Phe Ser Ser Pro Gln His Pro Phe Glu Ala Ala Thr 
65                  70                  75              

<210>  2542
<211>  3810
<212>  DNA
<213>  Homo sapiens

<400>  2542
ctccactaaa cctcagctac catccagagc ctcctattag acaatcaagt gtgtgccaga     60

gggagggacc aaaggggtgg ggtggggggg agtttaatca ttgaaccaag caggctggag    120

gtatttagtc cgcaacacct cgctccccag gaggtctgcc agcctggact ggaagcgtgc    180

aacactccag agtcgtagga gtgaacactg cacaggaatc tctgcccatc tcaggagaaa    240

ccaaacttgg ggaaaatgtt tgcggtccac ttgatggcat tttacttcag caagctgaag    300

gaggaccaga tcaagaaggt ggacaggttc ctgtatcaca tgcggctctc cgatgacacc    360

cttttggaca tcatgaggcg gttccgggct gagatggaga agggcctggc aaaggacacc    420

aaccccacgg ctgcagtgaa gatgttgccc accttcgtca gggccattcc cgatggttcc    480

gaaaatgggg agttcctttc cctggatctc ggagggtcca agttccgagt gctgaaggtg    540

caagtcgctg aagaggggaa gcgacacgtg cagatggaga gtcagttcta cccaacgccc    600

aatgaaatca tccgcgggaa cggcacagag ctgtttgaat atgtagctga ctgtctggca    660

gatttcatga agaccaaaga tttaaagcat aagaaattgc cccttggcct aactttttct    720

ttcccctgtc gacagactaa actggaagag ggtgtcctac tttcgtggac aaaaaagttt    780

aaggcacgag gagttcagga cacggatgtg gtgagccgtc tgaccaaagc catgagaaga    840

cacaaggaca tggacgtgga catcctggcc ctggtcaatg acaccgtggg gaccatgatg    900

acctgtgcct atgacgaccc ctactgcgaa gttggtgtca tcatcggaac tggcaccaat    960

gcgtgttaca tggaggacat gagcaacatt gacctggtgg agggcgacga gggcaggatg   1020

tgcatcaaca cagagtgggg ggccttcggg gacgacgggg ccctggagga cattcgcact   1080

gagttcgaca gggagctgga cctcggctct ctcaacccag gaaagcaact gttcgagaag   1140

atgatcagtg gcctgtacct gggggagctt gtcaggctta tcttgctgaa gatggccaag   1200

gctggcctcc tgtttggtgg tgagaaatct tctgctctcc acactaaggg caagatcgaa   1260

acacggcacg tggctgccat ggagaagtat aaagaaggcc ttgctaatac aagagagatc   1320

ctggtggacc tgggtctgga accgtctgag gctgactgca ttgccgtcca gcatgtctgt   1380

accatcgtct ccttccgctc ggccaatctc tgtgcagcag ctctggcggc catcctgaca   1440

cgcctccggg agaacaagaa ggtggaacgg ctccggacca cagtgggcat ggacggcacc   1500

ctctacaaga tacaccctca gtacccaaaa cgcctgcaca aggtggtgag gaaactggtc   1560

ccaagctgtg atgtccgctt cctcctgtca gagagtggca gcaccaaggg ggccgccatg   1620

gtgaccgcgg tggcctcccg cgtgcaggcc cagcggaagc agatcgacag ggtgctggct   1680

ttgttccagc tgacccgaga gcagctcgtg gacgtgcagg ccaagatgcg ggctgagctg   1740

gagtatgggc tgaagaagaa gagccacggg ctggccacgg tcaggatgct gcccacctac   1800

gtctgcgggc tgccggacgg cacagagaaa ggaaagtttc tcgccctgga tcttggggga   1860

accaacttcc gggtcctcct ggtgaagatc agaagtggac ggaggtcagt gcgaatgtac   1920

aacaagatct tcgccatccc cctggagatc atgcagggca ctggtgagga gctctttgat   1980

cacattgtgc agtgcatcgc cgacttcctg gactacatgg gcctcaaggg agcctcccta   2040

cctttgggct tcacattctc atttccctgc aggcagatga gcattgacaa gggaacactc   2100

atagggtgga ccaaaggttt caaggccact gactgtgaag gggaggacgt ggtggacatg   2160

ctcagggaag ccatcaagag gagaaacgag tttgacctgg acattgttgc agtcgtgaat   2220

gatacagtgg ggaccatgat gacctgtggc tatgaagatc ctaattgtga gattggcctg   2280

attgcaggaa caggcagcaa catgtgctac atggaggaca tgaggaacat cgagatggtg   2340

gaggggggtg aagggaagat gtgcatcaat acagagtggg gaggatttgg agacaatggc   2400

tgcatagatg acatctggac ccgatacgac acggaggtgg atgaggggtc cttgaatcct   2460

ggcaagcaga gatacgagaa aatgaccagt gggatgtact tgggggagat tgtgcggcag   2520

atcctgatcg acctgaccaa gcagggtctc ctcttccgag ggcagatttc agagcgtctc   2580

cggaccaggg gcatcttcga aaccaagttc ctgtcccaga tcgaaagcga tcggctggcc   2640

cttctccagg tcaggaggat tctgcagcag ctgggcctgg acagcacgtg tgaggacagc   2700

atcgtggtga aggaggtgtg cggagccgtg tcccggcggg cggcccagct ctgcggtgct   2760

ggcctggccg ctatagtgga aaaaaggaga gaagaccagg ggctagagca cctgaggatc   2820

actgtgggtg tggacggcac cctgtacaag ctgcaccctc acttttctag aatattgcag   2880

gaaactgtga aggaactagc ccctcgatgt gatgtgacat tcatgctgtc agaagatggc   2940

agtggaaaag gggcagcact gatcactgct gtggccaaga ggttacagca ggcacagaag   3000

gagaactagg aacccctggg attggacctg atgcatcttg gatactgaac agcttttcct   3060

ctggcagatc agttggtcag agaccaatgg gcaccctcct ggctgacctc accttctgga   3120

tggccgaaag agaaccccag gttctcgggt actcttagta tcttgtactg gatttgcagt   3180

gacattacat gacatctcta tttggtatat ttgggccaaa atgggccaac ttatgaaatc   3240

aaagtgtctg tcctgagaga tcccctttca acacattgtt caggtgaggc ttgagctgtc   3300

aattctctat ggctttcagt cttgtggctg cgggacttgg aaatatatag aatctgccca   3360

tgtggctggc aggctgtttc cccattggga tgcttaagcc atctcttata ggggattgga   3420

ccctgtactt gtggatgaac attggagagc aagaggaact cacgttatga actaggggga   3480

tctcatctaa cttgtcctta acttgccatg ttgacttcaa acctattaag agaacaaaga   3540

ctttgaagta tccagcccca gggtgcagag aggttgattg ccagggagca ctgcaggaat   3600

cattgcatgc ttaaagcgag ttatgtcagc accctgtagg attttgttcc ttattaagtg   3660

tgtgccatgt ggtggggtgc tgtctggggc atctgttttt cattttgcct gtggtttgtg   3720

ttgcaggtgt tgatagttgt tttaaggatt gttaggtata ggaaatccag taaattaata   3780

aaaaaatttt gattttccaa taaactttgc                                    3810


<210>  2543
<211>  917
<212>  PRT
<213>  Homo sapiens

<400>  2543


Met Phe Ala Val His Leu Met Ala Phe Tyr Phe Ser Lys Leu Lys Glu 
1               5                   10                  15      


Asp Gln Ile Lys Lys Val Asp Arg Phe Leu Tyr His Met Arg Leu Ser 
            20                  25                  30          


Asp Asp Thr Leu Leu Asp Ile Met Arg Arg Phe Arg Ala Glu Met Glu 
        35                  40                  45              


Lys Gly Leu Ala Lys Asp Thr Asn Pro Thr Ala Ala Val Lys Met Leu 
    50                  55                  60                  


Pro Thr Phe Val Arg Ala Ile Pro Asp Gly Ser Glu Asn Gly Glu Phe 
65                  70                  75                  80  


Leu Ser Leu Asp Leu Gly Gly Ser Lys Phe Arg Val Leu Lys Val Gln 
                85                  90                  95      


Val Ala Glu Glu Gly Lys Arg His Val Gln Met Glu Ser Gln Phe Tyr 
            100                 105                 110         


Pro Thr Pro Asn Glu Ile Ile Arg Gly Asn Gly Thr Glu Leu Phe Glu 
        115                 120                 125             


Tyr Val Ala Asp Cys Leu Ala Asp Phe Met Lys Thr Lys Asp Leu Lys 
    130                 135                 140                 


His Lys Lys Leu Pro Leu Gly Leu Thr Phe Ser Phe Pro Cys Arg Gln 
145                 150                 155                 160 


Thr Lys Leu Glu Glu Gly Val Leu Leu Ser Trp Thr Lys Lys Phe Lys 
                165                 170                 175     


Ala Arg Gly Val Gln Asp Thr Asp Val Val Ser Arg Leu Thr Lys Ala 
            180                 185                 190         


Met Arg Arg His Lys Asp Met Asp Val Asp Ile Leu Ala Leu Val Asn 
        195                 200                 205             


Asp Thr Val Gly Thr Met Met Thr Cys Ala Tyr Asp Asp Pro Tyr Cys 
    210                 215                 220                 


Glu Val Gly Val Ile Ile Gly Thr Gly Thr Asn Ala Cys Tyr Met Glu 
225                 230                 235                 240 


Asp Met Ser Asn Ile Asp Leu Val Glu Gly Asp Glu Gly Arg Met Cys 
                245                 250                 255     


Ile Asn Thr Glu Trp Gly Ala Phe Gly Asp Asp Gly Ala Leu Glu Asp 
            260                 265                 270         


Ile Arg Thr Glu Phe Asp Arg Glu Leu Asp Leu Gly Ser Leu Asn Pro 
        275                 280                 285             


Gly Lys Gln Leu Phe Glu Lys Met Ile Ser Gly Leu Tyr Leu Gly Glu 
    290                 295                 300                 


Leu Val Arg Leu Ile Leu Leu Lys Met Ala Lys Ala Gly Leu Leu Phe 
305                 310                 315                 320 


Gly Gly Glu Lys Ser Ser Ala Leu His Thr Lys Gly Lys Ile Glu Thr 
                325                 330                 335     


Arg His Val Ala Ala Met Glu Lys Tyr Lys Glu Gly Leu Ala Asn Thr 
            340                 345                 350         


Arg Glu Ile Leu Val Asp Leu Gly Leu Glu Pro Ser Glu Ala Asp Cys 
        355                 360                 365             


Ile Ala Val Gln His Val Cys Thr Ile Val Ser Phe Arg Ser Ala Asn 
    370                 375                 380                 


Leu Cys Ala Ala Ala Leu Ala Ala Ile Leu Thr Arg Leu Arg Glu Asn 
385                 390                 395                 400 


Lys Lys Val Glu Arg Leu Arg Thr Thr Val Gly Met Asp Gly Thr Leu 
                405                 410                 415     


Tyr Lys Ile His Pro Gln Tyr Pro Lys Arg Leu His Lys Val Val Arg 
            420                 425                 430         


Lys Leu Val Pro Ser Cys Asp Val Arg Phe Leu Leu Ser Glu Ser Gly 
        435                 440                 445             


Ser Thr Lys Gly Ala Ala Met Val Thr Ala Val Ala Ser Arg Val Gln 
    450                 455                 460                 


Ala Gln Arg Lys Gln Ile Asp Arg Val Leu Ala Leu Phe Gln Leu Thr 
465                 470                 475                 480 


Arg Glu Gln Leu Val Asp Val Gln Ala Lys Met Arg Ala Glu Leu Glu 
                485                 490                 495     


Tyr Gly Leu Lys Lys Lys Ser His Gly Leu Ala Thr Val Arg Met Leu 
            500                 505                 510         


Pro Thr Tyr Val Cys Gly Leu Pro Asp Gly Thr Glu Lys Gly Lys Phe 
        515                 520                 525             


Leu Ala Leu Asp Leu Gly Gly Thr Asn Phe Arg Val Leu Leu Val Lys 
    530                 535                 540                 


Ile Arg Ser Gly Arg Arg Ser Val Arg Met Tyr Asn Lys Ile Phe Ala 
545                 550                 555                 560 


Ile Pro Leu Glu Ile Met Gln Gly Thr Gly Glu Glu Leu Phe Asp His 
                565                 570                 575     


Ile Val Gln Cys Ile Ala Asp Phe Leu Asp Tyr Met Gly Leu Lys Gly 
            580                 585                 590         


Ala Ser Leu Pro Leu Gly Phe Thr Phe Ser Phe Pro Cys Arg Gln Met 
        595                 600                 605             


Ser Ile Asp Lys Gly Thr Leu Ile Gly Trp Thr Lys Gly Phe Lys Ala 
    610                 615                 620                 


Thr Asp Cys Glu Gly Glu Asp Val Val Asp Met Leu Arg Glu Ala Ile 
625                 630                 635                 640 


Lys Arg Arg Asn Glu Phe Asp Leu Asp Ile Val Ala Val Val Asn Asp 
                645                 650                 655     


Thr Val Gly Thr Met Met Thr Cys Gly Tyr Glu Asp Pro Asn Cys Glu 
            660                 665                 670         


Ile Gly Leu Ile Ala Gly Thr Gly Ser Asn Met Cys Tyr Met Glu Asp 
        675                 680                 685             


Met Arg Asn Ile Glu Met Val Glu Gly Gly Glu Gly Lys Met Cys Ile 
    690                 695                 700                 


Asn Thr Glu Trp Gly Gly Phe Gly Asp Asn Gly Cys Ile Asp Asp Ile 
705                 710                 715                 720 


Trp Thr Arg Tyr Asp Thr Glu Val Asp Glu Gly Ser Leu Asn Pro Gly 
                725                 730                 735     


Lys Gln Arg Tyr Glu Lys Met Thr Ser Gly Met Tyr Leu Gly Glu Ile 
            740                 745                 750         


Val Arg Gln Ile Leu Ile Asp Leu Thr Lys Gln Gly Leu Leu Phe Arg 
        755                 760                 765             


Gly Gln Ile Ser Glu Arg Leu Arg Thr Arg Gly Ile Phe Glu Thr Lys 
    770                 775                 780                 


Phe Leu Ser Gln Ile Glu Ser Asp Arg Leu Ala Leu Leu Gln Val Arg 
785                 790                 795                 800 


Arg Ile Leu Gln Gln Leu Gly Leu Asp Ser Thr Cys Glu Asp Ser Ile 
                805                 810                 815     


Val Val Lys Glu Val Cys Gly Ala Val Ser Arg Arg Ala Ala Gln Leu 
            820                 825                 830         


Cys Gly Ala Gly Leu Ala Ala Ile Val Glu Lys Arg Arg Glu Asp Gln 
        835                 840                 845             


Gly Leu Glu His Leu Arg Ile Thr Val Gly Val Asp Gly Thr Leu Tyr 
    850                 855                 860                 


Lys Leu His Pro His Phe Ser Arg Ile Leu Gln Glu Thr Val Lys Glu 
865                 870                 875                 880 


Leu Ala Pro Arg Cys Asp Val Thr Phe Met Leu Ser Glu Asp Gly Ser 
                885                 890                 895     


Gly Lys Gly Ala Ala Leu Ile Thr Ala Val Ala Lys Arg Leu Gln Gln 
            900                 905                 910         


Ala Gln Lys Glu Asn 
        915         

<210>  2544
<211>  1630
<212>  DNA
<213>  Homo sapiens

<400>  2544
aaagcgagcg aagctagggt cgccgccact gccgcaggag gcgtgagggg ataaaaacat     60

tcagatggca gatcacagtt tttcagatgg ggttccttca gattccgtgg aagctgctaa    120

aaatgcaagt aacacagaaa agctcacaga tcaggtgatg cagaatcctc gagttctggc    180

agctttacag gagcgacttg acaatgtccc tcacacccct tccagctaca tcgaaacttt    240

acctaaagca gtaaaaagaa gaattaatgc attgaaacaa cctgcaggat attaaagtga    300

aattttctga ccctggacag cctatgtctt ttgtgttaga gttccacttt gaacccaacg    360

actactttac caactcagtc ctgacaaaaa cctacaagat gaaatcagaa ccagataagg    420

ctgatccctt ttcctttgaa ggtcctgaga ttgtggactg tgacgggtgt actattgact    480

ggaagaaagg aaagaatgtt actgtcaaaa ccatcaagaa aaagcagaac acaatcccgt    540

ggacagagct tactccatct aactcgtttt caagtgcatg attttcactt tcacttttcc    600

tttttcctta ttattttgct taacttgtac agtggcaact gaaatgcatt tcagaaatag    660

gaggtttcgt ccagcaccct ctgcagcctt ggtgcctgta gctctggact tccctgggcc    720

tttccctgtg ggagggccct gtagaccaca tcagggtggg gtgggggtca cttggcaaaa    780

agggccgagg tctggtgatg tggttcccag gatctggaac ctctcccacc cctcctgcag    840

ttggactgaa ttcttccctt tcatccgaag aaacccactt gctgtttcca gccgctgaat    900

ctgctgagtg tgcagcctgc atcacctgct gtatgccgat catctcagaa agggctgtgt    960

agagtagggc cctgttctcc ttaggatgtt gcttcttgat tttttttttt ttttaggggt   1020

gggtcagggt tgtgacacac cagcccaggt gagagctgct gcgggtcacc tcatatttat   1080

ttatcccttc ttgcctgtga ggactgcggc ttttcgctgt ggctcgtcct taacgtttct   1140

gaaccacctt ggtgccctga gcaggaagat gtgccacttc ctagcaggcg caaggcctgt   1200

gcggaagaaa cgccgctccc tgccaccagg gctgaagatg cgagcccgtc ctcatgacgc   1260

aggcgccacc ctgctgccgg agccgggctt cggcagtctt ctccactgag ggactgggct   1320

gggaagtcct gcgtttcagt ggagcgtatg agcgtcaagt cctgctttct cagtagcccc   1380

attgcggggc cccaccattc atcctgtctg aaggtcctgg gtttggtgtg accgcttggc   1440

ggctggtggg tggggttttc aagtgggtga cggcgctctc cggcagccgg ggatggccgt   1500

gtccgcactg accaggcctg tggagagtgc tcggcctaac cttagaacac atttgtaact   1560

gaatacagtg ttttcaattt gtacagaata gttagaatat tctattaaag tggtgaaaca   1620

ttgagtcagc                                                          1630


<210>  2545
<211>  85
<212>  PRT
<213>  Homo sapiens

<400>  2545


Met Ser Phe Val Leu Glu Phe His Phe Glu Pro Asn Asp Tyr Phe Thr 
1               5                   10                  15      


Asn Ser Val Leu Thr Lys Thr Tyr Lys Met Lys Ser Glu Pro Asp Lys 
            20                  25                  30          


Ala Asp Pro Phe Ser Phe Glu Gly Pro Glu Ile Val Asp Cys Asp Gly 
        35                  40                  45              


Cys Thr Ile Asp Trp Lys Lys Gly Lys Asn Val Thr Val Lys Thr Ile 
    50                  55                  60                  


Lys Lys Lys Gln Asn Thr Ile Pro Trp Thr Glu Leu Thr Pro Ser Asn 
65                  70                  75                  80  


Ser Phe Ser Ser Ala 
                85  

<210>  2546
<211>  2561
<212>  DNA
<213>  Homo sapiens

<400>  2546
gaagcgcagt tgacttgcgc cgcgctcggc gaatcgcagc ctgtcttgct cgcggagaga     60

ggagctagga gcctcggcca atgggagccg gcgttgttgg aggccacggc ggcgcagccc    120

caaagcgagc gaagctaggg tcgccgccac tgccgcagga ggcgtgaggg gataaaaaca    180

ttcagatggc agatcacagt ttttcagatg gggttccttc agattccgtg gaagctgcta    240

aaaatgcaag taacacagaa aagctcacag atcaggtgat gcagaatcct cgagttctgg    300

cagctttaca ggagcgactt gacaatgtcc ctcacacccc ttccagctac atcgaaactt    360

tacctaaagc agtaaaaaga agaattaatg cattgaaaca acttcaggtg agatgtgctc    420

acatagaagc caagttctat gaagaggtac atgacttgga aagaaagtat gcagcgctat    480

accagcctct ctttgacaag agaagagaat ttatcaccgg cgatgttgaa ccaacagatg    540

cggaatcgga atggcacagt gaaaatgaag aggaagagaa attggctgga gacatgaaaa    600

gtaaagtagt cgtcacagaa aaagcagcgg caacggctga agagccagat cccaaaggaa    660

ttccagagtt ctggtttacc atcttcagaa atgtggacat gctgagtgaa ttagtccagg    720

aatatgatga accaatcttg aaacacctgc aggatattaa agtgaaattt tctgaccctg    780

gacagcctat gtcttttgtg ttagagttcc actttgaacc caacgactac tttaccaact    840

cagtcctgac aaaaacctac aagatgaaat cagaaccaga taaggctgat cccttttcct    900

ttgaaggtcc tgagattgtg gactgtgacg ggtgtactat tgactggaag aaaggaaaga    960

atgttactgt caaaaccatc aagaaaaagc agaagcataa gggtcgaggc actgttagaa   1020

caattacgaa acaagtaccc aatgagtcct ttttcaactt cttcaatcca ttgaaagcat   1080

ccggggatgg agaatcactg gatgaagatt ctgaattcac attagcctct gattttgaaa   1140

ttggacactt tttccgtgag cggatagtcc cgcgggctgt gctgtacttc actggggagg   1200

ccatagaaga tgatgacaat tttgaagaag gtgaagaagg agaagaggag gaattagaag   1260

gtgacgagga gggagaagac gaggatgatg cggaaattaa ccccaaggtg taatttttgt   1320

ctgttaatca ttcatacgtt tctagaagga acccagccag ccggcggaat gcaagcagca   1380

gtaggaagcg gaggcgggtg cctggcagac cggctgtcgg gactccaggc ctgtgggcgg   1440

ggcctcggtc cttgccgcag cacaatcccg tggacagagc ttactccatc taactcgttt   1500

tcaagtgcat gattttcact ttcacttttc ctttttcctt attattttgc ttaacttgta   1560

cagtggcaac tgaaatgcat ttcagaaata ggaggtttcg tccagcaccc tctgcagcct   1620

tggtgcctgt agctctggac ttccctgggc ctttccctgt gggagggccc tgtagaccac   1680

atcagggtgg ggtgggggtc acttggcaaa aagggccgag gtctggtgat gtggttccca   1740

ggatctggaa cctctcccac ccctcctgca gttggactga attcttccct ttcatccgaa   1800

gaaacccact tgctgtttcc agccgctgaa tctgctgagt gtgcagcctg catcacctgc   1860

tgtatgccga tcatctcaga aagggctgtg tagagtaggg ccctgttctc cttaggatgt   1920

tgcttcttga tttttttttt tttttagggg tgggtcaggg ttgtgacaca ccagcccagg   1980

tgagagctgc tgcgggtcac ctcatattta tttatccctt cttgcctgtg aggactgcgg   2040

cttttcgctg tggctcgtcc ttaacgtttc tgaaccacct tggtgccctg agcaggaaga   2100

tgtgccactt cctagcaggc gcaaggcctg tgcggaagaa acgccgctcc ctgccaccag   2160

ggctgaagat gcgagcccgt cctcatgacg caggcgccac cctgctgccg gagccgggct   2220

tcggcagtct tctccactga gggactgggc tgggaagtcc tgcgtttcag tggagcgtat   2280

gagcgtcaag tcctgctttc tcagtagccc cattgcgggg ccccaccatt catcctgtct   2340

gaaggtcctg ggtttggtgt gaccgcttgg cggctggtgg gtggggtttt caagtgggtg   2400

acggcgctct ccggcagccg gggatggccg tgtccgcact gaccaggcct gtggagagtg   2460

ctcggcctaa ccttagaaca catttgtaac tgaatacagt gttttcaatt tgtacagaat   2520

agttagaata ttctattaaa gtggtgaaac attgagtcag c                       2561


<210>  2547
<211>  375
<212>  PRT
<213>  Homo sapiens

<400>  2547


Met Ala Asp His Ser Phe Ser Asp Gly Val Pro Ser Asp Ser Val Glu 
1               5                   10                  15      


Ala Ala Lys Asn Ala Ser Asn Thr Glu Lys Leu Thr Asp Gln Val Met 
            20                  25                  30          


Gln Asn Pro Arg Val Leu Ala Ala Leu Gln Glu Arg Leu Asp Asn Val 
        35                  40                  45              


Pro His Thr Pro Ser Ser Tyr Ile Glu Thr Leu Pro Lys Ala Val Lys 
    50                  55                  60                  


Arg Arg Ile Asn Ala Leu Lys Gln Leu Gln Val Arg Cys Ala His Ile 
65                  70                  75                  80  


Glu Ala Lys Phe Tyr Glu Glu Val His Asp Leu Glu Arg Lys Tyr Ala 
                85                  90                  95      


Ala Leu Tyr Gln Pro Leu Phe Asp Lys Arg Arg Glu Phe Ile Thr Gly 
            100                 105                 110         


Asp Val Glu Pro Thr Asp Ala Glu Ser Glu Trp His Ser Glu Asn Glu 
        115                 120                 125             


Glu Glu Glu Lys Leu Ala Gly Asp Met Lys Ser Lys Val Val Val Thr 
    130                 135                 140                 


Glu Lys Ala Ala Ala Thr Ala Glu Glu Pro Asp Pro Lys Gly Ile Pro 
145                 150                 155                 160 


Glu Phe Trp Phe Thr Ile Phe Arg Asn Val Asp Met Leu Ser Glu Leu 
                165                 170                 175     


Val Gln Glu Tyr Asp Glu Pro Ile Leu Lys His Leu Gln Asp Ile Lys 
            180                 185                 190         


Val Lys Phe Ser Asp Pro Gly Gln Pro Met Ser Phe Val Leu Glu Phe 
        195                 200                 205             


His Phe Glu Pro Asn Asp Tyr Phe Thr Asn Ser Val Leu Thr Lys Thr 
    210                 215                 220                 


Tyr Lys Met Lys Ser Glu Pro Asp Lys Ala Asp Pro Phe Ser Phe Glu 
225                 230                 235                 240 


Gly Pro Glu Ile Val Asp Cys Asp Gly Cys Thr Ile Asp Trp Lys Lys 
                245                 250                 255     


Gly Lys Asn Val Thr Val Lys Thr Ile Lys Lys Lys Gln Lys His Lys 
            260                 265                 270         


Gly Arg Gly Thr Val Arg Thr Ile Thr Lys Gln Val Pro Asn Glu Ser 
        275                 280                 285             


Phe Phe Asn Phe Phe Asn Pro Leu Lys Ala Ser Gly Asp Gly Glu Ser 
    290                 295                 300                 


Leu Asp Glu Asp Ser Glu Phe Thr Leu Ala Ser Asp Phe Glu Ile Gly 
305                 310                 315                 320 


His Phe Phe Arg Glu Arg Ile Val Pro Arg Ala Val Leu Tyr Phe Thr 
                325                 330                 335     


Gly Glu Ala Ile Glu Asp Asp Asp Asn Phe Glu Glu Gly Glu Glu Gly 
            340                 345                 350         


Glu Glu Glu Glu Leu Glu Gly Asp Glu Glu Gly Glu Asp Glu Asp Asp 
        355                 360                 365             


Ala Glu Ile Asn Pro Lys Val 
    370                 375 

<210>  2548
<211>  671
<212>  DNA
<213>  Homo sapiens

<400>  2548
gcagcctgtc ttgctcgcgg agagaggagc taggagcctc ggccaatggg agccggcgtt     60

gttggaggcc acggcggcgc agccccaaag cgagcgaagc tagggtcgcc gccactgccg    120

caggaggcgt gaggggataa aaacattcag atggcagatc acagtttttc agatggggtt    180

ccttcagatt ccgtggaagc tgctaaaaat gcaagtaaca cagaaaagct cacagatcag    240

gtgatgcaga atcctcgagt tctggcagct ttacaggagc gacttgacaa tgtccctcac    300

accccttcca gctacatcga aactttacct aaagcagtaa aaagaagaat taatgcattg    360

aaacaacttc aggtgagatg tgctcacata gaagccaagt tctatgaaga ggtacatgac    420

ttggaaagaa agtatgcagc gctataccag cctctctttg acaagagaag agaatttatc    480

accggcgatg ttgaaccaac agatgcggaa tcggaatggc acagtgaaaa tgaagaggaa    540

gagaaattgg ctgtaaaaag gaaagaatgt tactgtcaaa accatcaaga aaaagcagaa    600

gcataagggt cgaggcactg ttagaacaat tacgaaacaa gtacccaatg agtccttttt    660

caacttcttc a                                                         671


<210>  2549
<211>  151
<212>  PRT
<213>  Homo sapiens

<400>  2549


Met Ala Asp His Ser Phe Ser Asp Gly Val Pro Ser Asp Ser Val Glu 
1               5                   10                  15      


Ala Ala Lys Asn Ala Ser Asn Thr Glu Lys Leu Thr Asp Gln Val Met 
            20                  25                  30          


Gln Asn Pro Arg Val Leu Ala Ala Leu Gln Glu Arg Leu Asp Asn Val 
        35                  40                  45              


Pro His Thr Pro Ser Ser Tyr Ile Glu Thr Leu Pro Lys Ala Val Lys 
    50                  55                  60                  


Arg Arg Ile Asn Ala Leu Lys Gln Leu Gln Val Arg Cys Ala His Ile 
65                  70                  75                  80  


Glu Ala Lys Phe Tyr Glu Glu Val His Asp Leu Glu Arg Lys Tyr Ala 
                85                  90                  95      


Ala Leu Tyr Gln Pro Leu Phe Asp Lys Arg Arg Glu Phe Ile Thr Gly 
            100                 105                 110         


Asp Val Glu Pro Thr Asp Ala Glu Ser Glu Trp His Ser Glu Asn Glu 
        115                 120                 125             


Glu Glu Glu Lys Leu Ala Val Lys Arg Lys Glu Cys Tyr Cys Gln Asn 
    130                 135                 140                 


His Gln Glu Lys Ala Glu Ala 
145                 150     

<210>  2550
<211>  983
<212>  DNA
<213>  Homo sapiens

<400>  2550
gaagcgcagt tgacttgcgc cgcgctcggc gaatcgcagc ctgtcttgct cgcggagaga     60

ggagctagga gcctcggcca atgggagccg gcgttgttgg aggccacggc ggcgcagccc    120

caaagcgagc gaagctaggg tcgccgccac tgccgcagga ggcgtgaggg gataaaaaca    180

ttcagatggc agatcacagt ttttcagatg gggttccttc agattccgtg gaagctgcta    240

aaaatgcaag taacacagaa aagctcacag atcaggtgat gcagaatcct cgagttctgg    300

cagctttaca ggagcgactt gacaatgtcc ctcacacccc ttccagctac atcgaaactt    360

tacctaaagc agtaaaaaga agaattaatg cattgaaaca acttcaggtg agatgtgctc    420

acatagaagc caagttctat gaagaggtac atgacttgga aagaaagtat gcagcgctat    480

accagcctct ctttgacaag agaagagaat ttatcaccgg cgatgttgaa ccaacagatg    540

cggaatcgga atggcacagt gaaaatgaag aggaagagaa attggctgga gacatgaaaa    600

gtaaagtagt cgtcacagaa aaagcagcgg caacggctga agagccagat cccaaaggaa    660

ttccagagtt ctggtttacc atcttcagaa atgtggacat gctgagtgaa ttagtccagg    720

aatatgatga accaatcttg aaacacctgc aggatattaa agtgaaattt tctgaccctg    780

gacagcctat gtcttttgtg ttagagttcc actttgaacc caacgactac tttaccaact    840

cagtcctgac aaaaacctac aagatgaaat cagaaccaga taaggctgat cccttttcct    900

ttgaaggtcc tgagattgtg gactgtgacg ggtgtactat tgactggaag aaaggaaaga    960

atgttactgt caaaaccatc aag                                            983


<210>  2551
<211>  265
<212>  PRT
<213>  Homo sapiens

<400>  2551


Met Ala Asp His Ser Phe Ser Asp Gly Val Pro Ser Asp Ser Val Glu 
1               5                   10                  15      


Ala Ala Lys Asn Ala Ser Asn Thr Glu Lys Leu Thr Asp Gln Val Met 
            20                  25                  30          


Gln Asn Pro Arg Val Leu Ala Ala Leu Gln Glu Arg Leu Asp Asn Val 
        35                  40                  45              


Pro His Thr Pro Ser Ser Tyr Ile Glu Thr Leu Pro Lys Ala Val Lys 
    50                  55                  60                  


Arg Arg Ile Asn Ala Leu Lys Gln Leu Gln Val Arg Cys Ala His Ile 
65                  70                  75                  80  


Glu Ala Lys Phe Tyr Glu Glu Val His Asp Leu Glu Arg Lys Tyr Ala 
                85                  90                  95      


Ala Leu Tyr Gln Pro Leu Phe Asp Lys Arg Arg Glu Phe Ile Thr Gly 
            100                 105                 110         


Asp Val Glu Pro Thr Asp Ala Glu Ser Glu Trp His Ser Glu Asn Glu 
        115                 120                 125             


Glu Glu Glu Lys Leu Ala Gly Asp Met Lys Ser Lys Val Val Val Thr 
    130                 135                 140                 


Glu Lys Ala Ala Ala Thr Ala Glu Glu Pro Asp Pro Lys Gly Ile Pro 
145                 150                 155                 160 


Glu Phe Trp Phe Thr Ile Phe Arg Asn Val Asp Met Leu Ser Glu Leu 
                165                 170                 175     


Val Gln Glu Tyr Asp Glu Pro Ile Leu Lys His Leu Gln Asp Ile Lys 
            180                 185                 190         


Val Lys Phe Ser Asp Pro Gly Gln Pro Met Ser Phe Val Leu Glu Phe 
        195                 200                 205             


His Phe Glu Pro Asn Asp Tyr Phe Thr Asn Ser Val Leu Thr Lys Thr 
    210                 215                 220                 


Tyr Lys Met Lys Ser Glu Pro Asp Lys Ala Asp Pro Phe Ser Phe Glu 
225                 230                 235                 240 


Gly Pro Glu Ile Val Asp Cys Asp Gly Cys Thr Ile Asp Trp Lys Lys 
                245                 250                 255     


Gly Lys Asn Val Thr Val Lys Thr Ile 
            260                 265 

<210>  2552
<211>  898
<212>  DNA
<213>  Homo sapiens

<400>  2552
cccaaagcga gcgaagctag ggtcgccgcc actgccgcag gaggcgtgag gggataaaaa     60

cattcagatg gcagatcaca gtttttcaga tggggttcct tcagattccg tggaagctgc    120

taaaaatgca agtaacacag aaaagctcac agatcaggtg atgcagaatc ctcgagttct    180

ggcagcttta caggagcgac ttgacaatgt ccctcacacc ccttccagct acatcgaaac    240

gcatgaggat gttgtatttc ttactccctt ttttagttta cctaaagcag taaaaagaag    300

aattaatgca ttgaaacaac ttcaggtgag atgtgctcac atagaagcca agttctatga    360

agaggtacat gacttggaaa gaaagtatgc agcgctatac cagcctctct ttgacaagag    420

aagagaattt atcaccggcg atgttgaacc aacagatgcg gaatcggaat ggcacagtga    480

aaatgaagag gaagagaaat tggctggaga catgaaaagt aaagtagtcg tcacagaaaa    540

agcagcggca acggctgaag agccagatcc caaaggaatt ccagagttct ggtttaccat    600

cttcagaaat gtggacatgc tgagtgaatt agtccaggaa tatgatgaac caatcttgaa    660

acacctgcag gatattaaag tgaaattttc tgaccctgga cagcctatgt cttttgtgtt    720

agagttccac tttgaaccca acgactactt taccaactca gtcctgacaa aaacctacaa    780

gatgaaatca gaaccagata aggctgatcc cttttccttt gaaggtcctg agattgtgga    840

ctgtgacggg tgtactattg actggaagaa aggaaagaat gttactgtca aaaccatc      898


<210>  2553
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  2553


Met Ala Asp His Ser Phe Ser Asp Gly Val Pro Ser Asp Ser Val Glu 
1               5                   10                  15      


Ala Ala Lys Asn Ala Ser Asn Thr Glu Lys Leu Thr Asp Gln Val Met 
            20                  25                  30          


Gln Asn Pro Arg Val Leu Ala Ala Leu Gln Glu Arg Leu Asp Asn Val 
        35                  40                  45              


Pro His Thr Pro Ser Ser Tyr Ile Glu Thr His Glu Asp Val Val Phe 
    50                  55                  60                  


Leu Thr Pro Phe Phe Ser Leu Pro Lys Ala Val Lys Arg Arg Ile Asn 
65                  70                  75                  80  


Ala Leu Lys Gln Leu Gln Val Arg Cys Ala His Ile Glu Ala Lys Phe 
                85                  90                  95      


Tyr Glu Glu Val His Asp Leu Glu Arg Lys Tyr Ala Ala Leu Tyr Gln 
            100                 105                 110         


Pro Leu Phe Asp Lys Arg Arg Glu Phe Ile Thr Gly Asp Val Glu Pro 
        115                 120                 125             


Thr Asp Ala Glu Ser Glu Trp His Ser Glu Asn Glu Glu Glu Glu Lys 
    130                 135                 140                 


Leu Ala Gly Asp Met Lys Ser Lys Val Val Val Thr Glu Lys Ala Ala 
145                 150                 155                 160 


Ala Thr Ala Glu Glu Pro Asp Pro Lys Gly Ile Pro Glu Phe Trp Phe 
                165                 170                 175     


Thr Ile Phe Arg Asn Val Asp Met Leu Ser Glu Leu Val Gln Glu Tyr 
            180                 185                 190         


Asp Glu Pro Ile Leu Lys His Leu Gln Asp Ile Lys Val Lys Phe Ser 
        195                 200                 205             


Asp Pro Gly Gln Pro Met Ser Phe Val Leu Glu Phe His Phe Glu Pro 
    210                 215                 220                 


Asn Asp Tyr Phe Thr Asn Ser Val Leu Thr Lys Thr Tyr Lys Met Lys 
225                 230                 235                 240 


Ser Glu Pro Asp Lys Ala Asp Pro Phe Ser Phe Glu Gly Pro Glu Ile 
                245                 250                 255     


Val Asp Cys Asp Gly Cys Thr Ile Asp Trp Lys Lys Gly Lys Asn Val 
            260                 265                 270         


Thr Val Lys Thr 
        275     

<210>  2554
<211>  671
<212>  DNA
<213>  Homo sapiens

<400>  2554
ctggggcgct ggcgggaggc ccctcccaac tcccggcgcg cctcgcccgg ctgcccgcct     60

cactgaaggt caaggcgctt tgttctgcgc cgcgggcggc ctcctgggcg gcggcccctt    120

ggaggaggcg aagacggcga gaggcggcgg ccgctcaaat ctcccgctag cccagcccgc    180

cccgcgtgcg ggggctgtgg cggttacacg gccgggcgcg ccggagcgtt caggcttccc    240

gtttttaagg ggataaaaac attcagatgg cagatcacag tttttcagat ggggttcctt    300

cagattccgt ggaagctgct aaaaatgcaa gtaacacaga aaagctcaca gatcaggtga    360

tgcagaatcc tcgagttctg gcagctttac aggagcgact tgacaatgtc cctcacaccc    420

cttccagcta catcgaaact ttacctaaag cagtaaaaag aagaattaat gcattgaaac    480

aacttcaggt gagatgtgct cacatagaag ccaagttcta tgaagaggta catgacttgg    540

aaagaaagta tgcagcgcta taccagcctc tctttgacaa gagaagagaa tttatcaccg    600

gcgatgttga accaacagat gcggaatcgg aatggcacag tgaaaatgaa gaggaagaga    660

aattggctgt a                                                         671


<210>  2555
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  2555


Met Ala Asp His Ser Phe Ser Asp Gly Val Pro Ser Asp Ser Val Glu 
1               5                   10                  15      


Ala Ala Lys Asn Ala Ser Asn Thr Glu Lys Leu Thr Asp Gln Val Met 
            20                  25                  30          


Gln Asn Pro Arg Val Leu Ala Ala Leu Gln Glu Arg Leu Asp Asn Val 
        35                  40                  45              


Pro His Thr Pro Ser Ser Tyr Ile Glu Thr Leu Pro Lys Ala Val Lys 
    50                  55                  60                  


Arg Arg Ile Asn Ala Leu Lys Gln Leu Gln Val Arg Cys Ala His Ile 
65                  70                  75                  80  


Glu Ala Lys Phe Tyr Glu Glu Val His Asp Leu Glu Arg Lys Tyr Ala 
                85                  90                  95      


Ala Leu Tyr Gln Pro Leu Phe Asp Lys Arg Arg Glu Phe Ile Thr Gly 
            100                 105                 110         


Asp Val Glu Pro Thr Asp Ala Glu Ser Glu Trp His Ser Glu Asn Glu 
        115                 120                 125             


Glu Glu Glu Lys Leu Ala 
    130                 

<210>  2556
<211>  544
<212>  DNA
<213>  Homo sapiens

<400>  2556
gtgaggaagt agctgatctc tgcaggaaac tgctgttacc tggcctcagc tgaatttttg     60

tgggacctcc tgagggcttg gcaccgcaga agtctctgaa gagacagtct gctgctgttt    120

ggaggggata aaaacattca gatggcagat cacagttttt cagatggggt tccttcagat    180

tccgtggaag ctgctaaaaa tgcaagtaac acagaaaagc tcacagatca ggtgatgcag    240

aatcctcgag ttctggcagc tttacaggag cgacttgaca atgtccctca caccccttcc    300

agctacatcg aaactttacc taaagcagta aaaagaagaa ttaatgcatt gaaacaactt    360

caggtgagat gtgctcacat agaagccaag ttctatgaag aggtacatga cttggaaaga    420

aagtatgcag cgctatacca gcctctcttt gacaagagaa gagaatttat caccggcgat    480

gttgaaccaa cagatgcgga atcggaatgg cacagtgaaa atgaagagga agagaaattg    540

gctg                                                                 544


<210>  2557
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  2557


Met Ala Asp His Ser Phe Ser Asp Gly Val Pro Ser Asp Ser Val Glu 
1               5                   10                  15      


Ala Ala Lys Asn Ala Ser Asn Thr Glu Lys Leu Thr Asp Gln Val Met 
            20                  25                  30          


Gln Asn Pro Arg Val Leu Ala Ala Leu Gln Glu Arg Leu Asp Asn Val 
        35                  40                  45              


Pro His Thr Pro Ser Ser Tyr Ile Glu Thr Leu Pro Lys Ala Val Lys 
    50                  55                  60                  


Arg Arg Ile Asn Ala Leu Lys Gln Leu Gln Val Arg Cys Ala His Ile 
65                  70                  75                  80  


Glu Ala Lys Phe Tyr Glu Glu Val His Asp Leu Glu Arg Lys Tyr Ala 
                85                  90                  95      


Ala Leu Tyr Gln Pro Leu Phe Asp Lys Arg Arg Glu Phe Ile Thr Gly 
            100                 105                 110         


Asp Val Glu Pro Thr Asp Ala Glu Ser Glu Trp His Ser Glu Asn Glu 
        115                 120                 125             


Glu Glu Glu Lys Leu 
    130             

<210>  2558
<211>  610
<212>  DNA
<213>  Homo sapiens

<400>  2558
aaagcgagcg aagctagggt cgccgccact gccgcaggag gcgtgaggga aaagtgtttt     60

aggcttccag agtagaaatc tgatattact tcgtttgatt cttcgaccac tatggtgata    120

ggaagtagct gatctctgca ggaaactgct gttacctggc ctcagctgaa tttttgtggg    180

acctcctgag gggataaaaa cattcagatg gcagatcaca gtttttcaga tggggttcct    240

tcagattccg tggaagctgc taaaaatgca agtaacacag aaaagctcac agatcaggtg    300

atgcagaatc ctcgagttct ggcagcttta caggagcgac ttgacaatgt ccctcacacc    360

ccttccagct acatcgaaac tttacctaaa gcagtaaaaa gaagaattaa tgcattgaaa    420

caacttcagg tgagatgtgc tcacatagaa gccaagttct atgaagaggt acatgacttg    480

gaaagaaagt atgcagcgct ataccagcct ctctttgaca agagaagaga atttatcacc    540

ggcgatgttg aaccaacaga tgcggaatcg gaatggcaca gtgaaaatga agaggaagag    600

aaattggctg                                                           610


<210>  2559
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  2559


Met Ala Asp His Ser Phe Ser Asp Gly Val Pro Ser Asp Ser Val Glu 
1               5                   10                  15      


Ala Ala Lys Asn Ala Ser Asn Thr Glu Lys Leu Thr Asp Gln Val Met 
            20                  25                  30          


Gln Asn Pro Arg Val Leu Ala Ala Leu Gln Glu Arg Leu Asp Asn Val 
        35                  40                  45              


Pro His Thr Pro Ser Ser Tyr Ile Glu Thr Leu Pro Lys Ala Val Lys 
    50                  55                  60                  


Arg Arg Ile Asn Ala Leu Lys Gln Leu Gln Val Arg Cys Ala His Ile 
65                  70                  75                  80  


Glu Ala Lys Phe Tyr Glu Glu Val His Asp Leu Glu Arg Lys Tyr Ala 
                85                  90                  95      


Ala Leu Tyr Gln Pro Leu Phe Asp Lys Arg Arg Glu Phe Ile Thr Gly 
            100                 105                 110         


Asp Val Glu Pro Thr Asp Ala Glu Ser Glu Trp His Ser Glu Asn Glu 
        115                 120                 125             


Glu Glu Glu Lys Leu 
    130             

<210>  2560
<211>  558
<212>  DNA
<213>  Homo sapiens

<400>  2560
gaggccacgg cggcgcagcc ccaaagcgag cgaagctagg gtcgccgcca ctgccgcagg     60

aggcgtgagg aagtagctga tctctgcagg aaactgctgt tacctggcct cagctgaatt    120

tttgtgggac ctcctgaggg gataaaaaca ttcagatggc agatcacagt ttttcagatg    180

gggttccttc agattccgtg gaagctgcta aaaatgcaag taacacagaa aagctcacag    240

atcaggtgat gcagaatcct cgagttctgg cagctttaca ggagcgactt gacaatgtcc    300

ctcacacccc ttccagctac atcgaaactt tacctaaagc agtaaaaaga agaattaatg    360

cattgaaaca acttcaggtg agatgtgctc acatagaagc caagttctat gaagaggtac    420

atgacttgga aagaaagtat gcagcgctat accagcctct ctttgacaag agaagagaat    480

ttatcaccgg cgatgttgaa ccaacagatg cggaatcgga atggcacagt gaaaatgaag    540

aggaagagaa attggctg                                                  558


<210>  2561
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  2561


Met Ala Asp His Ser Phe Ser Asp Gly Val Pro Ser Asp Ser Val Glu 
1               5                   10                  15      


Ala Ala Lys Asn Ala Ser Asn Thr Glu Lys Leu Thr Asp Gln Val Met 
            20                  25                  30          


Gln Asn Pro Arg Val Leu Ala Ala Leu Gln Glu Arg Leu Asp Asn Val 
        35                  40                  45              


Pro His Thr Pro Ser Ser Tyr Ile Glu Thr Leu Pro Lys Ala Val Lys 
    50                  55                  60                  


Arg Arg Ile Asn Ala Leu Lys Gln Leu Gln Val Arg Cys Ala His Ile 
65                  70                  75                  80  


Glu Ala Lys Phe Tyr Glu Glu Val His Asp Leu Glu Arg Lys Tyr Ala 
                85                  90                  95      


Ala Leu Tyr Gln Pro Leu Phe Asp Lys Arg Arg Glu Phe Ile Thr Gly 
            100                 105                 110         


Asp Val Glu Pro Thr Asp Ala Glu Ser Glu Trp His Ser Glu Asn Glu 
        115                 120                 125             


Glu Glu Glu Lys Leu 
    130             

<210>  2562
<211>  827
<212>  DNA
<213>  Homo sapiens

<400>  2562
tgacaggtta ggaagttttc atttcagttt caaattcaaa ttcatactgt aaagtggtga     60

tgaacacatc ccatccgcag gtacttaacc tccatacaaa taagaactac ctctcatatg    120

ggcaaaaaga tcaaaattct acagaagaat ctgatggcta aatggctaat ttgcaaaaca    180

caatgccctg tacattttga ggacatccta aaacatgtgt aaacttttca gaattcagtt    240

taccaaagtt atcaaactta aaaatgatta aaatttattt gctactgcaa agaattcaac    300

caatttctcc aatgactact ccatattcat tttgaaaaac agtaccggat ttaaagctta    360

cacaacaaaa ttcacaaaag tgttatatgt gcctatatga catataggca caaataactg    420

cagacattct gaagctaaca ctgctcaacc aggaaaaaaa aaagactgca attggatatg    480

taataacagc tatttaagac ggcagtaacg tgttaaaatg gttcataaaa atcacatcat    540

aaggccctga aattctagta aaaatatctc taagtaaact tgtgaactac tactaaataa    600

ctaattttct ctctctctgt agtcactcat tttatctttg gattactttc ccattctatc    660

accacgttgc tttctctgaa cttcatttta catttgcata ttatttattc cattagcaat    720

tgctcatccc agtctgaatc tcaaaattct actataggag gcatttggca ttctgtggaa    780

taagagaatt ttgagatgga aatgatcaac cagctcaaaa ccccgta                  827


<210>  2563
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  2563


Met Gly Lys Lys Ile Lys Ile Leu Gln Lys Asn Leu Met Ala Lys Trp 
1               5                   10                  15      


Leu Ile Cys Lys Thr Gln Cys Pro Val His Phe Glu Asp Ile Leu Lys 
            20                  25                  30          


His Val 
        

<210>  2564
<211>  1127
<212>  DNA
<213>  Homo sapiens

<400>  2564
ctgcccggca catgggcttg tctccccaca gtggggaggg cctggtcaga gttcagccct     60

ccatgccagg ccctaggaga ggggcttgtt tggctagacc tctcactccg agagacccag    120

cagcctgagg cagccctgtc tcatctggct ctgtattgac cctccaggtt gaagaggaga    180

agaggaagaa gaaagaggag gcggcccgga ggaaacagga acaagaagta atgcattttg    240

tttgggggtg agggctctac tgggcaggag tgcaccctga ccccatgccc tgtggctctc    300

tgtgcctccg tggaccttag ccaggcccct gcagaccctc acagaaggag ctccgctttc    360

tgcctccacc acccaaggcc tgccaggccc ttctcacatg gggtgcaggg aaggcctggc    420

caaggggaag gctgtgccat gtggtcacaa gctccaagac agcgtttata gacttactac    480

tattaggttt tctagtaagc tttccactat tcctgtagaa ataacatctg gtttaatttt    540

aaattccttg tatgttccct ccaccttggc tttccccttc ccatctttca tagcactctg    600

aatctgaggg cttggaagca agttgagggc tggaggtatg agcagatgtc gttcacagtg    660

cggagcccca ggtgctgctc gggggcagtg actgtgccgt gttgcgtgtt ctaggcagca    720

aagctggcca agatgaagat tccccccagt gagatgttct tgtcagaaac cgacaaatac    780

tccaagtttg atgaaaatgg tctgcccaca catgacatgg agggcaaaga gctcagcaaa    840

gggcaagcca agaagctgaa gaagctcttc gaggctcagg agaagctcta caaggaatat    900

ctgcagatgg cccagaatgg aagcttccag tgagggggca caggactgac tttttaaacc    960

attgtggact agtggctgct gtctgcctca gtgacaatgt cccagcgctc ctatcatgtt   1020

tacagtcacc cttgggtcct aaattaagag ttgtgttcat gtaggttcgt gtcgtcgttg   1080

gctctgagac attgataata aatttttctc aacagtgaga ccctctc                 1127


<210>  2565
<211>  66
<212>  PRT
<213>  Homo sapiens

<400>  2565


Met Lys Ile Pro Pro Ser Glu Met Phe Leu Ser Glu Thr Asp Lys Tyr 
1               5                   10                  15      


Ser Lys Phe Asp Glu Asn Gly Leu Pro Thr His Asp Met Glu Gly Lys 
            20                  25                  30          


Glu Leu Ser Lys Gly Gln Ala Lys Lys Leu Lys Lys Leu Phe Glu Ala 
        35                  40                  45              


Gln Glu Lys Leu Tyr Lys Glu Tyr Leu Gln Met Ala Gln Asn Gly Ser 
    50                  55                  60                  


Phe Gln 
65      

<210>  2566
<211>  2280
<212>  DNA
<213>  Homo sapiens

<400>  2566
aatggtcctt ctgtaagaaa gctgattctg gcaccaacag agaggctgcc tcagatgaag     60

agtgttagca cccgaaggga cccccaggcc tgtcctgacc ctcccacccc tgctgtcggc    120

ccaacttgtg tccctttcct ggaagaactg cttccggcgg ccagtgtgct atgcttcctc    180

ctggctctgc cctgcacccc cagaacagcc cctgggctta cgggagacac tagtctctgg    240

gcttctgcag ccaatcaagc tgctgggccc tccctcccaa gcactggagg aggtactcgt    300

tctgtgggcc ggggcccctc cctcctgagc actggaggag gcacttgttc tgtgggccac    360

ggcccctcct tccccagcac tggaggaggc actggttgtg tgggccctgg ctcctccatg    420

tctgagggaa ctgctctgct tctcctacag tccctgagat tctgcagctc agcgatgccc    480

tgcgggacaa catcctgccc gagcttgggg tgcggtttga agaccacgaa ggactgccca    540

cagtggtgaa actggtagac agaaacacct tattaaaaga gagagaagaa aagagacggg    600

ttgaagagga gaagaggaag aagaaagagg aggcggcccg gaggaaacag gaacaagaag    660

taatgcattt tgtttggggg tgagggctct actgggcagg agtgcaccct gaccccatgc    720

cctgtggctc tctgtgcctc cgtggacctt agccaggccc ctgcagaccc tcacagaagg    780

agctccgctt tctgcctcca ccacccaagg cctgccaggc ccttctcaca tggggtgcag    840

ggaaggcctg gccaagggga aggctgtgcc atgtggtcac aagctccaag acagcgttta    900

tagacttact actattaggt tttctagtaa gctttccact attcctgtag aaataacatc    960

tggtttaatt ttaaattcct tgtatgttcc ctccaccttg gctttcccct tcccatcttt   1020

catagcactc tgaatctgag ggcttggaag caagttgagg gctggaggta tgagcagatg   1080

tcgttcacag tgcggagccc caggtgctgc tcgggggcag tgactgtgcc gtgttgcgtg   1140

ttctaggcag caaagctggc caagatgaag attcccccca gtgagatgtt cttgtcagaa   1200

accgacaaat actccaagtt tgatgaaaat gtaagcatgt aagcatcctt ctcttctatt   1260

cagaacttga tcagaccaca ttaaagtggg aggacaggaa ttttcaacct tggacaagca   1320

gattttctgt ctgtagaaaa tttggaatca aatctgacac ccgctttagg tccagggcct   1380

cctggcccaa ctactgagct ccttccacag cccaggcagc taggcaagcc cgtgccaggg   1440

ccccctccac tggtgtggtg agctctggtc cctagccctg ggagttgtgg ccccgggcca   1500

agatccaccc aggccctcac aagctggctg aagtgccgtg gcgcagatag gcctcctacc   1560

cccagtttct tcctttgtca tagcgattca cagccactgc ctccaaacct ctaggcccct   1620

ccctgctggc atttggatgt gtttgctatg tacctttggg ccagctgtgt cagaactcag   1680

ccatgggtag gctctgaggg gcacagtgcc cctcacctta ggcaggaagc acccccagac   1740

tctggtcgcc cctctcccat tcttagctgc tggagccagc actgccagat gagtgtgctg   1800

gctccagagc agtgtggtga ctgaatgtcc aagcaagagg acatggctgc atcagggaga   1860

tagacacttt gagacgggag ggcaaagaaa ggggagttgg ggttacccag gtgcagagga   1920

gaccaatagc cgctgtgctc tgggttttca gggtctgccc acacatgaca tggagggcaa   1980

agagctcagc aaagggcaag ccaagaagct gaagaagctc ttcgaggctc aggagaagct   2040

ctacaaggaa tatctgcaga tggcccagaa tggaagcttc cagtgagggg gcacaggact   2100

gactttttaa accattgtgg actagtggct gctgtctgcc tcagtgacaa tgtcccagcg   2160

ctcctatcat gtttacagtc acccttgggt cctaaattaa gagttgtgtt catgtaggtt   2220

cgtgtcgtcg ttggctctga gacattgata ataaattttt ctcaacagtg agaccctctc   2280


<210>  2567
<211>  164
<212>  PRT
<213>  Homo sapiens

<400>  2567


Met Lys Ser Val Ser Thr Arg Arg Asp Pro Gln Ala Cys Pro Asp Pro 
1               5                   10                  15      


Pro Thr Pro Ala Val Gly Pro Thr Cys Val Pro Phe Leu Glu Glu Leu 
            20                  25                  30          


Leu Pro Ala Ala Ser Val Leu Cys Phe Leu Leu Ala Leu Pro Cys Thr 
        35                  40                  45              


Pro Arg Thr Ala Pro Gly Leu Thr Gly Asp Thr Ser Leu Trp Ala Ser 
    50                  55                  60                  


Ala Ala Asn Gln Ala Ala Gly Pro Ser Leu Pro Ser Thr Gly Gly Gly 
65                  70                  75                  80  


Thr Arg Ser Val Gly Arg Gly Pro Ser Leu Leu Ser Thr Gly Gly Gly 
                85                  90                  95      


Thr Cys Ser Val Gly His Gly Pro Ser Phe Pro Ser Thr Gly Gly Gly 
            100                 105                 110         


Thr Gly Cys Val Gly Pro Gly Ser Ser Met Ser Glu Gly Thr Ala Leu 
        115                 120                 125             


Leu Leu Leu Gln Ser Leu Arg Phe Cys Ser Ser Ala Met Pro Cys Gly 
    130                 135                 140                 


Thr Thr Ser Cys Pro Ser Leu Gly Cys Gly Leu Lys Thr Thr Lys Asp 
145                 150                 155                 160 


Cys Pro Gln Trp 
                

<210>  2568
<211>  2681
<212>  DNA
<213>  Homo sapiens

<400>  2568
caggtgctgg cttgccttcc ttctaatgag ggtgctatcc aggggtggct ttcaaagagt     60

gaagggcagg cacctacctc agctcatgcc ccagtcagct gctcctcagg tggctgagga    120

gggcctgttc ccaggaatga tactgcagac aaatataaag gccattgttc ccctaggtct    180

ctgcctgggg aggttgaaac tccggaagct gcccaaagtg gctgtgctta tgagcgcggc    240

cttgaagccc aaggatatgc aatttttttt tttttttttt gagatggagt cttgccctgt    300

cgctaggctg gagtgcagtg gtgtcatctt ggcccactgc aacctccgac tccctggttc    360

aagcgattct tctgcctcag cgtcccaagt agctgggatt acaggcacat gccaccacac    420

ccagatagtt tttgtatttt tagtagagat ggggtttcac catgttggcc aggatggtct    480

cgatctcctg accttgtgat ccacccgcct cagcctccaa aagtgctggg attacagtca    540

tgagccaccg tgcctgcccg gatatgtgaa tattttatct agcagtgaat gaaggtgtgg    600

ggtgcccagc aaggagctct aggggtctca gttatgagga cacagcagga aaaggacaga    660

cgagaatggc agcatgtgca tggtcagtgc tgcccaaagg cagggcaggc aggaggatgg    720

ggtgggatgg tgggggtccc agcaggctgg ggggcagggc acctgcccgc ctagcacagt    780

tgggcgcagc aagctgaggg gccagaagaa aactaaaggg tgtggtgatt ccagcaaacc    840

caaggtcaga tttcagagca gaaagttgtc acttggagag cagcaagcat ctgtcctgtt    900

gatgtagtct aggagatgct gtcacatcac ctgatactct ggagtctttc tgagataggt    960

tggcatccca tttaccctgt aacacccaaa acttcttatg tcctgttctc tacctgggcg   1020

ttgtgcgtgg gctgggaacg ggaaaactcg ggcagagcag agacacagag ggggcgcctg   1080

ctagagactg cgtgaggagc ccactaggag aaccgtggga tgccgggcaa gtctgcactg   1140

ctgcgctctg aagtcagcca cagacacatg ggtttccaag cgaagctccc tccccatgtg   1200

atggaggtca cagtcgccct ccctgtcatg cctcctttca ccctcccagc tgggtcaggt   1260

ccccagtcag aggcagaggt gagcacagtc ttgggaagca acctgcggtc cacccccacc   1320

gctcagcccc gcctttacag ctgcgtgcgc ttcagccctg ggagggctga ttctcacaga   1380

gctcgagctc cttggtggtc ctgggactca gctctcctgg gtgccggtca ggacccccat   1440

cgcagtcccg tgtgcatttg ggaaccaagt ccttggggct tgagtgtaaa tggtccttct   1500

gtaagaaagc tgattctggc accaacagag aggctgcctc agatgaagag tgttagcacc   1560

cgaagggacc cccaggcctg tcctgaccct cccacccctg ctgtcggccc aacttgtgtc   1620

cctttcctgg aagaactgct tccggcggcc agtgtgctat gcttcctcct ggctctgccc   1680

tgcaccccca gaacagcccc tgggcttacg ggagacacta gtctctgggc ttctgcagcc   1740

aatcaagctg ctgggccctc cctcccaagc actggaggag gtactcgttc tgtgggccgg   1800

ggcccctccc tcctgagcac tggaggaggc acttgttctg tgggccacgg cccctccttc   1860

cccagcactg gaggaggcac tggttgtgtg ggccctggct cctccatgtc tgagggaact   1920

gctctgcttc tcctacagtc cctgagattc tgcagctcag cgatgccctg cgggacaaca   1980

tcctgcccga gcttggggtg cggtttgaag accacgaagg actgcccaca gtggtgaaac   2040

tggtagacag aaacacctta ttaaaagaga gagaagaaaa gagacgggtt gaagaggaga   2100

agaggaagaa gaaagaggag gcggcccgga ggaaacagga acaagaacac tctgaatctg   2160

agggcttgga agcaagttga gggctggagg tatgagcaga tgtcgttcac agtgcggagc   2220

cccaggtgct gctcgggggc agtgactgtg ccgtgttgcg tgttctaggc agcaaagctg   2280

gccaagatga agattccccc cagtgagatg ttcttgtcag aaaccgacaa atactccaag   2340

tttgatgaaa atggtctgcc cacacatgac atggagggca aagagctcag caaagggcaa   2400

gccaagaagc tgaagaagct cttcgaggct caggagaagc tctacaagga atatctgcag   2460

atggcccaga atggaagctt ccagtgaggg ggcacaggac tgacttttta aaccattgtg   2520

gactagtggc tgctgtctgc ctcagtgaca atgtcccagc gctcctatca tgtttacagt   2580

cacccttggg tcctaaatta agagttgtgt tcatgtaggt tcgtgtcgtc gttggctctg   2640

agacattgat aataaatttt tctcaacagt gagaccctct c                       2681


<210>  2569
<211>  305
<212>  PRT
<213>  Homo sapiens

<400>  2569


Met Pro Gly Lys Ser Ala Leu Leu Arg Ser Glu Val Ser His Arg His 
1               5                   10                  15      


Met Gly Phe Gln Ala Lys Leu Pro Pro His Val Met Glu Val Thr Val 
            20                  25                  30          


Ala Leu Pro Val Met Pro Pro Phe Thr Leu Pro Ala Gly Ser Gly Pro 
        35                  40                  45              


Gln Ser Glu Ala Glu Val Ser Thr Val Leu Gly Ser Asn Leu Arg Ser 
    50                  55                  60                  


Thr Pro Thr Ala Gln Pro Arg Leu Tyr Ser Cys Val Arg Phe Ser Pro 
65                  70                  75                  80  


Gly Arg Ala Asp Ser His Arg Ala Arg Ala Pro Trp Trp Ser Trp Asp 
                85                  90                  95      


Ser Ala Leu Leu Gly Ala Gly Gln Asp Pro His Arg Ser Pro Val Cys 
            100                 105                 110         


Ile Trp Glu Pro Ser Pro Trp Gly Leu Ser Val Asn Gly Pro Ser Val 
        115                 120                 125             


Arg Lys Leu Ile Leu Ala Pro Thr Glu Arg Leu Pro Gln Met Lys Ser 
    130                 135                 140                 


Val Ser Thr Arg Arg Asp Pro Gln Ala Cys Pro Asp Pro Pro Thr Pro 
145                 150                 155                 160 


Ala Val Gly Pro Thr Cys Val Pro Phe Leu Glu Glu Leu Leu Pro Ala 
                165                 170                 175     


Ala Ser Val Leu Cys Phe Leu Leu Ala Leu Pro Cys Thr Pro Arg Thr 
            180                 185                 190         


Ala Pro Gly Leu Thr Gly Asp Thr Ser Leu Trp Ala Ser Ala Ala Asn 
        195                 200                 205             


Gln Ala Ala Gly Pro Ser Leu Pro Ser Thr Gly Gly Gly Thr Arg Ser 
    210                 215                 220                 


Val Gly Arg Gly Pro Ser Leu Leu Ser Thr Gly Gly Gly Thr Cys Ser 
225                 230                 235                 240 


Val Gly His Gly Pro Ser Phe Pro Ser Thr Gly Gly Gly Thr Gly Cys 
                245                 250                 255     


Val Gly Pro Gly Ser Ser Met Ser Glu Gly Thr Ala Leu Leu Leu Leu 
            260                 265                 270         


Gln Ser Leu Arg Phe Cys Ser Ser Ala Met Pro Cys Gly Thr Thr Ser 
        275                 280                 285             


Cys Pro Ser Leu Gly Cys Gly Leu Lys Thr Thr Lys Asp Cys Pro Gln 
    290                 295                 300                 


Trp 
305 

<210>  2570
<211>  2476
<212>  DNA
<213>  Homo sapiens

<400>  2570
catttacagt gttgtgcagc cgccaccgtc catctccaga actcttccct tttcccaaac     60

tggaactctg tccccatgga acagcaactc cacatcccct ccctcagccc ctggtgctca    120

ccctctactt ctgtctcttt ggattttact actccaggga ccctacatga gtggagtcac    180

acagtgtttg tcctgtgtct ggcttatttc gctgatcacg gtgtcctcag gtctatccat    240

gttgcagcct gtgtcaggac ctcctgcctt tttaatggcc aaatcatatt ccatggatgg    300

atgggccctg atctgtctat tcttccatgg aagaattctc atcacctttg cgttatcttt    360

gtagcccaca tttctcttca gtaaatccct gatgatgatg tcattgtctg ctcctctgcc    420

ccagctctgc taacagaagc cacagaggct tcttcctcag ctcctcagaa tccagaccca    480

gaggtcggtg tgggcctgag gggtacggcg tgtgtccctt tcccccaggg agtgtggccc    540

gggaggcttt cttggtgcct gctctgatga tcacccatgg cgggtgggct ggggtgctgg    600

ccttgtggcc tcccatgaca cccgtgacag tgaccacagg tgctggcttg ccttccttct    660

aatgagggtg ctatccaggg gtggctttca aagagtgaag ggcaggcacc tacctcagct    720

catgccccag tcagctgctc ctcaggtggc tgaggagggc ctgttcccag gaatgatact    780

gcagacaaat ataaaggcca ttgttcccct aggtctctgc ctggggaggt tgaaactccg    840

gaagctgccc aaagtggctg tgcttatgag cgcggccttg aagcccaagg atatgcaatt    900

tttttttttt ttttttgaga tggagtcttg ccctgtcgct aggctggagt gcagtggtgt    960

catcttggcc cactgcaacc tccgactccc tggttcaagc gattcttctg cctcagcgtc   1020

ccaagtagct gggattacag gcacatgcca ccacacccag atagtttttg tatttttagt   1080

agagatgggg tttcaccatg ttggccagga tggtctcgat ctcctgacct tgtgatccac   1140

ccgcctcagc ctccaaaagt gctgggatta cagtcatgag ccaccgtgcc tgcccggata   1200

tgtgaatatt ttatctagca gtgaatgaag gtgtggggtg cccagcaagg agctctaggg   1260

gtctcagtta tgaggacaca gcaggaaaag gacagacgag aatggcagca tgtgcatggt   1320

cagtgctgcc caaaggcagg gcaggcagga ggatggggtg ggatggtggg ggtcccagca   1380

ggctgggggg cagggcacct gcccgcctag cacagttggg cgcagcaagc tgaggggcca   1440

gaagaaaact aaagggtgtg gtgattccag caaacccaag gtcagatttc agagcagaaa   1500

gttgtcactt ggagagcagc aagcatctgt cctgttgatg tagtctagga gatgctgtca   1560

catcacctga tactctggag tctttctgag ataggttggc atcccattta ccctgtaaca   1620

cccaaaactt cttatgtcct gttctctacc tgggcgttgt gcgtgggctg ggaacgggaa   1680

aactcgggca gagcagagac acagaggggg cgcctgctag agactgcgtg aggagcccac   1740

taggagaacc gtgggatgcc gggcaagtct gcactgctgc gctctgaagt cagccacaga   1800

cacatgggtt tccaagcgaa gctccctccc catgtgatgg aggtcacagt cgccctccct   1860

gtcatgcctc ctttcaccct cccagctggg tcaggtcccc agtcagaggc agagtccctg   1920

agattctgca gctcagcgat gccctgcggg acaacatcct gcccgagctt ggggtgcggt   1980

ttgaagacca cgaaggactg cccacagtgg tgaaactggt agacagaaac accttattaa   2040

aagagagaga agaaaagaga cgggcagcaa agctggccaa gatgaagatt ccccccagtg   2100

agatgttctt gtcagaaacc gacaaatact ccaagtttga tgaaaatggt ctgcccacac   2160

atgacatgga gggcaaagag ctcagcaaag ggcaagccaa gaagctgaag aagctcttcg   2220

aggctcagga gaagctctac aaggaatatc tgcagatggc ccagaatgga agcttccagt   2280

gagggggcac aggactgact ttttaaacca ttgtggacta gtggctgctg tctgcctcag   2340

tgacaatgtc ccagcgctcc tatcatgttt acagtcaccc ttgggtccta aattaagagt   2400

tgtgttcatg taggttcgtg tcgtcgttgg ctctgagaca ttgataataa atttttctca   2460

acagtgagac cctctc                                                   2476


<210>  2571
<211>  85
<212>  PRT
<213>  Homo sapiens

<400>  2571


Met Pro Gly Lys Ser Ala Leu Leu Arg Ser Glu Val Ser His Arg His 
1               5                   10                  15      


Met Gly Phe Gln Ala Lys Leu Pro Pro His Val Met Glu Val Thr Val 
            20                  25                  30          


Ala Leu Pro Val Met Pro Pro Phe Thr Leu Pro Ala Gly Ser Gly Pro 
        35                  40                  45              


Gln Ser Glu Ala Glu Ser Leu Arg Phe Cys Ser Ser Ala Met Pro Cys 
    50                  55                  60                  


Gly Thr Thr Ser Cys Pro Ser Leu Gly Cys Gly Leu Lys Thr Thr Lys 
65                  70                  75                  80  


Asp Cys Pro Gln Trp 
                85  

<210>  2572
<211>  5750
<212>  DNA
<213>  Homo sapiens

<400>  2572
gtctccaggt gaagaggcga cttgcacttc ctggtgctgc ccctggaccc tgatcctgct     60

ctctctgcct cccaggcaaa ggccggcgtg tgcagcccca gtggtcccct cctgctggga    120

cccagccatg cagactccac ctttacaaca gcctcaccag gaacaagtgt ttcttgcatt    180

tcttgtgatc gtcattcctt cattcctaac aaaggaagtg ttcatacctc aagatgggaa    240

aaaggtgacg tggtattgct gtgggccaac cgtctatgac gcatctcaca tggggcacgc    300

caggtcctac atctcttttg atatcttgag aagagtgttg aaggattact tcaaatttga    360

tgtcttttat tgcatgaaca ttacggatat tgatgacaag atcatcaaga gggcccggca    420

gaaccacctg ttcgagcagt atcgggagaa gaggcctgaa gcggcacagc tcttggagga    480

tgttcaggcc gccctgaagc cattttcagt aaaattaaat gagaccacgg atcccgataa    540

aaagcagatg ctcgaacgga ttcagcacgc agtgcagctt gccacagagc cacttgagaa    600

agctgtgcag tccagactca cgggagagga agtcaacagc tgtgtggagg tgttgctgga    660

agaagccaag gatttgctct ctgactggct ggattctaca cttggctgtg atgtcactga    720

caattccatc ttctccaagc tgcccaagtt ctgggagggg gacttccaca gagacatgga    780

agctctgaat gttctccctc cagatgtctt aacccgggtt agtgagtatg tgccagaaat    840

tgtgaacttt gtccagaaga ttgtggacaa cggttacggg taagcacaag ggccttccct    900

agggagggaa gggctgcaga acatcgcaca gggaggagct ccccagctct gagcctgagt    960

ttgggaagca gaggagcagg tgttctgggg ctgcgtagct agaagtccca gcagacttcc   1020

tcctacaact ctgggcccac ccaggggctg aggagcatgg gtctgcactg tcctgggggc   1080

catggtgaga acctaaccca gaatctgctg ggaagctcgg cagccaagac catcagtcat   1140

ggggccccag agctgcataa tggtgagtgc gaatactgct gggccttcac agacatcagt   1200

gccattgcgt agacattttg agagtgctag tcctggtgtc atatcccgaa ggaggatgca   1260

tttcatcagc atctatcgct tggctatgat tttagtgact ttttgttggc aaatccatca   1320

tacacttccc tggcccgtat tgtctcaatc tccaaagtaa gcattttcag aaatggccaa   1380

caaatggaaa tgcagacagg aacccggtta tctgtctgta gtgtgtaggg accagcccca   1440

cagggtcggt gggtttttct ccccatgtgt ggagatgaga gattgtagaa ataaagacac   1500

aagacaaaga gataaaagag aagacagctg ggcccggggg accactacca ccaagacgcg   1560

gagaccggta gtggccccga atgccaggct gcactgatat ttattggata caagacaaag   1620

gggtaggtta aggagagtga gccatcttca atgataggta aggccacgtg ggtcacgtgt   1680

ccactggaca gggggccctt ccctgcctgg cagccaaggc agagagagag aggagacaga   1740

gagaggcagc ttacgccatt atttctgcat atcagagact tttagtactt tcactaattt   1800

gctactgcta tctagaaggt agagccaggt gtacaggatg gaacatgaag gaggactagg   1860

agcgtgaccg ctgaagcaca gcatcacagg gagacggtta ggcctccgga taactgcggg   1920

cgagcctgac tcatgtcagg ccctccacaa gaggtggagg agcagagtct tctccagact   1980

cccgcggggc aagggagact ccctttcccg gtctgctaag tagcgggtgt ttttccttga   2040

cacttacgct accgctagac cacagtccgc ttggcaacgg gcatcctccc agacgctggc   2100

gttaccacta gaccaaggaa cccttctggt ggccgtgtcc gggcataaca ggaggttcac   2160

actcttgtct tctggtcact cctcactatg tcccctcagc tgctatctct gtatggcctg   2220

gtttttccta gattatgatt atagagcgag gattattata atattggaat aaagagtaat   2280

tgctacaaac taatgattaa tgatattcat atataatcat atctaagatc tatatctggt   2340

ataactattc ttattttata ttttattata ctggaacagc tcgtgccctc ggtctcttgc   2400

ctcggcacct gggtggcttg ccgcccacag tagtgctcag cactgtaccg tgcgcctgct   2460

cccagagacc cactgtgtcc agcctcagat tgcttccctc ccacaggaac cacacaggct   2520

ggatgaaaga gaaacaagag gttgtgacag tgccaggaac ggggcagact cttaagcagt   2580

agcgctgctt ctctccccac ttcacacaaa ctactgtggg gcagcataag agcctgtgcc   2640

aagccgagag gcatgggcaa gccgaagctc agagaggaca ggtcattcca gactggagta   2700

atctagagtg cttcttggag gccaagagcc tcagctaagc taatgggtag agtgtggaca   2760

ttcagggaaa ggtgaggcca cacaagaatg aggacggcag cagccctgag caaggcaggg   2820

tgggagctgc atgggtcaca ggacgccagg cagagggacg agctgcccag ggcaggcagg   2880

ctgcctccgc agcgggatgg gccctggtgt cccactcagt ccaaacagct gatacggttt   2940

tcagtggcca ccacagagag tagataggcc acagatttcg cacttttata gccctgcttt   3000

attttgttac tgtcatcctg ctgacacact ttcgggtctg ttagatgcac ccacccaatt   3060

ccttttctgt tttccagcta tgtctccaat gggtctgtct actttgatac agcgaagttt   3120

gcttctagcg agaagcactc ctatgggaag ctggtgcctg aggccgttgg agatcagaaa   3180

gcccttcaag aaggggaagg tgacctgagc atctctgcag accgcctgag tgagaagcgc   3240

tctcccaacg actttgcctt atggaaggcc tctaagcccg gagaaccgtc ctggccgtgc   3300

ccttggggaa agggtcgtcc gggctggcat atcgagtgct cggccatggc aggcaccctc   3360

ctaggggctt cgatggacat tcacggaggt gggttcgacc tccggttccc ccaccatgac   3420

aatgagctgg cacagtcgga ggcctacttt gaaaacgact gctgggtcag gtacttcctg   3480

cacacaggcc acctgaccat tgcaggctgc aaaatgtcaa agtcactaaa aaacttcatc   3540

accattaaag atgccttgaa aaagcactca gcacggcagt tgcggctggc cttcctcatg   3600

cactcgtgga aggacaccct ggactactcc agcaacacca tggagtcagc gcttcaatat   3660

gagaagttct tgaatgtgag tccccagccc cttcctggag gttggtggag cagcctcccc   3720

tgcacagtgg gcaccttgtg cagtggtgat aggtgcacca gcctcccgat gtctctaatg   3780

gagaccagca catgggtgga agcacctcca tgctagtggg tataacaggc tcggggccac   3840

tcctgaaatg gctgacggct cagcagagtg gacagaggcc tcgtcctcct agtcactgca   3900

gtgcacgtcc ttctgacttg tactttccac caaatgagca tctgtaaacc taaagcaaga   3960

gcatgtttct gtcaaagaaa tatcttttcc tttctttctg accacttgtg taattctggt   4020

ctttcagatt tttaccaaaa ataaaatcac agcagtagaa agttgtaaca gatatttcag   4080

gatggaaaag ttgcctaaat gctgttaaac tgatttttct aacttcagga gtttttctta   4140

aatgtgaaag atatccttcg cgctcctgtt gacatcactg gtcagtttga gaagtgggga   4200

gaagaagaag cagaactgaa taagaagtaa ggtggtgcca tttctttggg gtttttgagc   4260

atgcccatgt tctatgccta gcctcgcatc ttggccacca tgtgtcctgg actgtcgagg   4320

aagggctggg gacactgtcg tacgttgtgc agaattaatt caggataggc ggctctgcta   4380

atgggagctg ctctgggtgt tgaagtgcat ggagaatttc ttttttgttt tttctttttg   4440

agacggagtt tcgcccttgt tgcccaggct ggagtgcagt ggcgtgatct cggctcacca   4500

caacctccac ctcccgggtt cgagcgattc tcctgcctca gcctcccgag tagctggggt   4560

tacaggcatg cgccaccata cctggctaat ttcagatttt tagtagaggt gggggtctct   4620

ccatgtttgt caggctggtc tcgaactccc gacctcaggt gatccgccca cctcagcctc   4680

ccaaagtgct gggattatag gcgtgagcca ctgcgcctgg ccacatgggg aatttctatg   4740

gtgtgttttc aggtctgact tcacattcct tcctctttgt tgctcagctt ttatgacaag   4800

aagacagcaa ttcacaaagc cctctgtgac aatgttgaca cccgcaccgt catggaagag   4860

atgcgggcct tggtcagtca gtgcaacctc tatatggcag cccggaaagc cgtgaggaag   4920

aggcccaacc aggctctgct ggagaacatc gccctgtacc tcacccatat gctgaagatc   4980

tttggggccg tagaagagga cagctccctg ggattcccgg tcggagggcc tggaaccagc   5040

ctcagtctcg aggccacagt catgccctac cttcaggtgt tatcagaatt ccgagaagga   5100

gtgcggaaga ttgcccgaga gcaaaaagtc cctgagattc tgcagctcag cgatgccctg   5160

cgggacaaca tcctgcccga gcttggggtg cggtttgaag accacgaagg actgcccaca   5220

gtggtgaaac tggtagacag aaacacctta ttaaaagaga gagaagaaaa gagacgggtt   5280

gaagaggaga agaggaagaa gaaagaggag gcggcccgga ggaaacagga acaagaagca   5340

gcaaagctgg ccaagatgaa gattcccccc agtgagatgt tcttgtcaga aaccgacaaa   5400

tactccaagt ttgatgaaaa tggtctgccc acacatgaca tggagggcaa agagctcagc   5460

aaagggcaag ccaagaagct gaagaagctc ttcgaggctc aggagaagct ctacaaggaa   5520

tatctgcaga tggcccagaa tggaagcttc cagtgagggg gcacaggact gactttttaa   5580

accattgtgg actagtggct gctgtctgcc tcagtgacaa tgtcccagcg ctcctatcat   5640

gtttacagtc acccttgggt cctaaattaa gagttgtgtt catgtaggtt cgtgtcgtcg   5700

ttggctctga gacattgata ataaattttt ctcaacagtg agaccctctc              5750


<210>  2573
<211>  251
<212>  PRT
<213>  Homo sapiens

<400>  2573


Met Gln Thr Pro Pro Leu Gln Gln Pro His Gln Glu Gln Val Phe Leu 
1               5                   10                  15      


Ala Phe Leu Val Ile Val Ile Pro Ser Phe Leu Thr Lys Glu Val Phe 
            20                  25                  30          


Ile Pro Gln Asp Gly Lys Lys Val Thr Trp Tyr Cys Cys Gly Pro Thr 
        35                  40                  45              


Val Tyr Asp Ala Ser His Met Gly His Ala Arg Ser Tyr Ile Ser Phe 
    50                  55                  60                  


Asp Ile Leu Arg Arg Val Leu Lys Asp Tyr Phe Lys Phe Asp Val Phe 
65                  70                  75                  80  


Tyr Cys Met Asn Ile Thr Asp Ile Asp Asp Lys Ile Ile Lys Arg Ala 
                85                  90                  95      


Arg Gln Asn His Leu Phe Glu Gln Tyr Arg Glu Lys Arg Pro Glu Ala 
            100                 105                 110         


Ala Gln Leu Leu Glu Asp Val Gln Ala Ala Leu Lys Pro Phe Ser Val 
        115                 120                 125             


Lys Leu Asn Glu Thr Thr Asp Pro Asp Lys Lys Gln Met Leu Glu Arg 
    130                 135                 140                 


Ile Gln His Ala Val Gln Leu Ala Thr Glu Pro Leu Glu Lys Ala Val 
145                 150                 155                 160 


Gln Ser Arg Leu Thr Gly Glu Glu Val Asn Ser Cys Val Glu Val Leu 
                165                 170                 175     


Leu Glu Glu Ala Lys Asp Leu Leu Ser Asp Trp Leu Asp Ser Thr Leu 
            180                 185                 190         


Gly Cys Asp Val Thr Asp Asn Ser Ile Phe Ser Lys Leu Pro Lys Phe 
        195                 200                 205             


Trp Glu Gly Asp Phe His Arg Asp Met Glu Ala Leu Asn Val Leu Pro 
    210                 215                 220                 


Pro Asp Val Leu Thr Arg Val Ser Glu Tyr Val Pro Glu Ile Val Asn 
225                 230                 235                 240 


Phe Val Gln Lys Ile Val Asp Asn Gly Tyr Gly 
                245                 250     

<210>  2574
<211>  2538
<212>  DNA
<213>  Homo sapiens

<400>  2574
gtctccaggt gaagaggcga cttgcacttc ctggtgctgc ccctggaccc tgatcctgct     60

ctctctgcct cccaggcaaa ggccggcgtg tgcagcccca gtggtcccct cctgctggga    120

cccagccatg cagactccac ctttacaaca gcctcaccag gaacaagtgt ttcttgcatt    180

tcttgtgatc gtcattcctt cattcctaac aaaggaagtg ttcatacctc aagatgggaa    240

aaaggtgacg tggtattgct gtgggccaac cgtctatgac gcatctcaca tggggcacgc    300

caggtcctac atctcttttg atatcttgag aagagtgttg aaggattact tcaaatttga    360

tgtcttttat tgcatgaaca ttacggatat tgatgacaag atcatcaaga gggcccggca    420

gaaccacctg ttcgagcagt atcgggagaa gaggcctgaa gcggcacagc tcttggagga    480

tgttcaggcc gccctgaagc cattttcagt aaaattaaat gagaccacgg atcccgataa    540

aaagcagatg ctcgaacgga ttcagcacgc agtgcagctt gccacagagc cacttgagaa    600

agctgtgcag tccagactca cgggagagga agtcaacagc tgtgtggagg tgttgctgga    660

agaagccaag gatttgctct ctgactggct ggattctaca cttggctgtg atgtcactga    720

caattccatc ttctccaagc tgcccaagtt ctgggagggg gacttccaca gagacatgga    780

agctctgaat gttctccctc cagatgtctt aacccgggtt agtgagtatg tgccagaaat    840

tgtgaacttt gtccagaaga ttgtggacaa cggttacggc tatgtctcca atgggtctgt    900

ctactttgat acagcgaagt ttgcttctag cgagaagcac tcctatggga agctggtgcc    960

tgaggccgtt ggagatcaga aagcccttca agaaggggaa ggtgacctga gcatctctgc   1020

agaccgcctg agtgagaagc gctctcccaa cgactttgcc ttatggaagg cctctaagcc   1080

cggagaaccg tcctggccgt gcccttgggg aaagggtcgt ccgggctggc atatcgagtg   1140

ctcggccatg gcaggcaccc tcctaggggc ttcgatggac attcacggag gtgggttcga   1200

cctccggttc ccccaccatg acaatgagct ggcacagtcg gaggcctact ttgaaaacga   1260

ctgctgggtc aggtacttcc tgcacacagg ccacctgacc attgcaggct gcaaaatgtc   1320

aaagtcacta aaaaacttca tcaccattaa agatgccttg aaaaagcact cagcacggca   1380

gttgcggctg gccttcctca tgcactcgtg gaaggacacc ctggactact ccagcaacac   1440

catggagtca gcgcttcaat atgagaagtt cttgaatgag tttttcttaa atgtgaaaga   1500

tatccttcgc gctcctgttg acatcactgg tcagtttgag aagtggggag aagaagaagc   1560

agaactgaat aagaactttt atgacaagaa gacagcaatt cacaaagccc tctgtgacaa   1620

tgttgacacc cgcaccgtca tggaagagat gcgggccttg gtcagtcagt gcaacctcta   1680

tatggcagcc cggaaagccg tgaggaagag gcccaaccag gctctgctgg agaacatcgc   1740

cctgtacctc acccatatgc tgaagatctt tggggccgta gaagaggaca gctccctggg   1800

attcccggtc ggagggcctg gaaccagcct cagtctcgag gccacagtca tgccctacct   1860

tcaggtgtta tcagaattcc gagaaggagt gcggaagatt gcccgagagc aaaaagtccc   1920

tgagattctg cagctcagcg atgccctgcg ggacaacatc ctgcccgagc ttggggtgcg   1980

gtttgaagac cacgaaggac tgcccacagt ggtgaaactg gtagacagaa acaccttatt   2040

aaaagagaga gaagaaaaga gacgggttga agaggagaag aggaagaaga aagaggaggc   2100

ggcccggagg aaacaggaac aagaagcagc aaagctggcc aagatgaaga ttccccccag   2160

tgagatgttc ttgtcagaaa ccgacaaata ctccaagttt gatgaaaatg gtctgcccac   2220

acatgacatg gagggcaaag agctcagcaa agggcaagcc aagaagctga agaagctctt   2280

cgaggctcag gagaagctct acaaggaata tctgcagatg gcccagaatg gaagcttcca   2340

gtgagggggc acaggactga ctttttaaac cattgtggac tagtggctgc tgtctgcctc   2400

agtgacaatg tcccagcgct cctatcatgt ttacagtcac ccttgggtcc taaattaaga   2460

gttgtgttca tgtaggttcg tgtcgtcgtt ggctctgaga cattgataat aaatttttct   2520

caacagtgag accctctc                                                 2538


<210>  2575
<211>  738
<212>  PRT
<213>  Homo sapiens

<400>  2575


Met Gln Thr Pro Pro Leu Gln Gln Pro His Gln Glu Gln Val Phe Leu 
1               5                   10                  15      


Ala Phe Leu Val Ile Val Ile Pro Ser Phe Leu Thr Lys Glu Val Phe 
            20                  25                  30          


Ile Pro Gln Asp Gly Lys Lys Val Thr Trp Tyr Cys Cys Gly Pro Thr 
        35                  40                  45              


Val Tyr Asp Ala Ser His Met Gly His Ala Arg Ser Tyr Ile Ser Phe 
    50                  55                  60                  


Asp Ile Leu Arg Arg Val Leu Lys Asp Tyr Phe Lys Phe Asp Val Phe 
65                  70                  75                  80  


Tyr Cys Met Asn Ile Thr Asp Ile Asp Asp Lys Ile Ile Lys Arg Ala 
                85                  90                  95      


Arg Gln Asn His Leu Phe Glu Gln Tyr Arg Glu Lys Arg Pro Glu Ala 
            100                 105                 110         


Ala Gln Leu Leu Glu Asp Val Gln Ala Ala Leu Lys Pro Phe Ser Val 
        115                 120                 125             


Lys Leu Asn Glu Thr Thr Asp Pro Asp Lys Lys Gln Met Leu Glu Arg 
    130                 135                 140                 


Ile Gln His Ala Val Gln Leu Ala Thr Glu Pro Leu Glu Lys Ala Val 
145                 150                 155                 160 


Gln Ser Arg Leu Thr Gly Glu Glu Val Asn Ser Cys Val Glu Val Leu 
                165                 170                 175     


Leu Glu Glu Ala Lys Asp Leu Leu Ser Asp Trp Leu Asp Ser Thr Leu 
            180                 185                 190         


Gly Cys Asp Val Thr Asp Asn Ser Ile Phe Ser Lys Leu Pro Lys Phe 
        195                 200                 205             


Trp Glu Gly Asp Phe His Arg Asp Met Glu Ala Leu Asn Val Leu Pro 
    210                 215                 220                 


Pro Asp Val Leu Thr Arg Val Ser Glu Tyr Val Pro Glu Ile Val Asn 
225                 230                 235                 240 


Phe Val Gln Lys Ile Val Asp Asn Gly Tyr Gly Tyr Val Ser Asn Gly 
                245                 250                 255     


Ser Val Tyr Phe Asp Thr Ala Lys Phe Ala Ser Ser Glu Lys His Ser 
            260                 265                 270         


Tyr Gly Lys Leu Val Pro Glu Ala Val Gly Asp Gln Lys Ala Leu Gln 
        275                 280                 285             


Glu Gly Glu Gly Asp Leu Ser Ile Ser Ala Asp Arg Leu Ser Glu Lys 
    290                 295                 300                 


Arg Ser Pro Asn Asp Phe Ala Leu Trp Lys Ala Ser Lys Pro Gly Glu 
305                 310                 315                 320 


Pro Ser Trp Pro Cys Pro Trp Gly Lys Gly Arg Pro Gly Trp His Ile 
                325                 330                 335     


Glu Cys Ser Ala Met Ala Gly Thr Leu Leu Gly Ala Ser Met Asp Ile 
            340                 345                 350         


His Gly Gly Gly Phe Asp Leu Arg Phe Pro His His Asp Asn Glu Leu 
        355                 360                 365             


Ala Gln Ser Glu Ala Tyr Phe Glu Asn Asp Cys Trp Val Arg Tyr Phe 
    370                 375                 380                 


Leu His Thr Gly His Leu Thr Ile Ala Gly Cys Lys Met Ser Lys Ser 
385                 390                 395                 400 


Leu Lys Asn Phe Ile Thr Ile Lys Asp Ala Leu Lys Lys His Ser Ala 
                405                 410                 415     


Arg Gln Leu Arg Leu Ala Phe Leu Met His Ser Trp Lys Asp Thr Leu 
            420                 425                 430         


Asp Tyr Ser Ser Asn Thr Met Glu Ser Ala Leu Gln Tyr Glu Lys Phe 
        435                 440                 445             


Leu Asn Glu Phe Phe Leu Asn Val Lys Asp Ile Leu Arg Ala Pro Val 
    450                 455                 460                 


Asp Ile Thr Gly Gln Phe Glu Lys Trp Gly Glu Glu Glu Ala Glu Leu 
465                 470                 475                 480 


Asn Lys Asn Phe Tyr Asp Lys Lys Thr Ala Ile His Lys Ala Leu Cys 
                485                 490                 495     


Asp Asn Val Asp Thr Arg Thr Val Met Glu Glu Met Arg Ala Leu Val 
            500                 505                 510         


Ser Gln Cys Asn Leu Tyr Met Ala Ala Arg Lys Ala Val Arg Lys Arg 
        515                 520                 525             


Pro Asn Gln Ala Leu Leu Glu Asn Ile Ala Leu Tyr Leu Thr His Met 
    530                 535                 540                 


Leu Lys Ile Phe Gly Ala Val Glu Glu Asp Ser Ser Leu Gly Phe Pro 
545                 550                 555                 560 


Val Gly Gly Pro Gly Thr Ser Leu Ser Leu Glu Ala Thr Val Met Pro 
                565                 570                 575     


Tyr Leu Gln Val Leu Ser Glu Phe Arg Glu Gly Val Arg Lys Ile Ala 
            580                 585                 590         


Arg Glu Gln Lys Val Pro Glu Ile Leu Gln Leu Ser Asp Ala Leu Arg 
        595                 600                 605             


Asp Asn Ile Leu Pro Glu Leu Gly Val Arg Phe Glu Asp His Glu Gly 
    610                 615                 620                 


Leu Pro Thr Val Val Lys Leu Val Asp Arg Asn Thr Leu Leu Lys Glu 
625                 630                 635                 640 


Arg Glu Glu Lys Arg Arg Val Glu Glu Glu Lys Arg Lys Lys Lys Glu 
                645                 650                 655     


Glu Ala Ala Arg Arg Lys Gln Glu Gln Glu Ala Ala Lys Leu Ala Lys 
            660                 665                 670         


Met Lys Ile Pro Pro Ser Glu Met Phe Leu Ser Glu Thr Asp Lys Tyr 
        675                 680                 685             


Ser Lys Phe Asp Glu Asn Gly Leu Pro Thr His Asp Met Glu Gly Lys 
    690                 695                 700                 


Glu Leu Ser Lys Gly Gln Ala Lys Lys Leu Lys Lys Leu Phe Glu Ala 
705                 710                 715                 720 


Gln Glu Lys Leu Tyr Lys Glu Tyr Leu Gln Met Ala Gln Asn Gly Ser 
                725                 730                 735     


Phe Gln 
        

<210>  2576
<211>  2764
<212>  DNA
<213>  Homo sapiens

<400>  2576
acttccgggg cggcggttgc atcagattct aggaagtgtc tgtagccgca gctgcgggtc     60

cgggattccc agccatggca gattcctccg ggcagcaggc tcctgactac aggtccattc    120

tgagcattag tgacgaggca gccagggcac aagccctgaa cgagcacctc agcacgcgta    180

gctatgtcca ggggtactca ctgtcccagg cagacgtgga cgcgttcagg cagctctcgg    240

ccccgcccgc tgacccccag ctcttccacg tggctcggtg gttcaggcac atagaagcgc    300

tcctgggtag cccctgtggc aaaggccagc cctgcaggct ccaagcaagc aaaggccggc    360

gtgtgcagcc ccagtggtcc cctcctgctg ggacccagcc atgcagactc cacctttaca    420

acagcctcac caggaacaag gaagtgttca tacctcaaga tgggaaaaag gtgacgtggt    480

attgctgtgg gccaaccgtc tatgacgcat ctcacatggg gcacgccagg tcctacatct    540

cttttgatat cttgagaaga gtgttgaagg attacttcaa atttgatgtc ttttattgca    600

tgaacattac ggatattgat gacaagatca tcaagagggc ccggcagaac cacctgttcg    660

agcagtatcg ggagaagagg cctgaagcgg cacagctctt ggaggatgtt caggccgccc    720

tgaagccatt ttcagtaaaa ttaaatgaga ccacggatcc cgataaaaag cagatgctcg    780

aacggattca gcacgcagtg cagcttgcca cagagccact tgagaaagct gtgcagtcca    840

gactcacggg agaggaagtc aacagctgtg tggaggtgtt gctggaagaa gccaaggatt    900

tgctctctga ctggctggat tctacacttg gctgtgatgt cactgacaat tccatcttct    960

ccaagctgcc caagttctgg gagggggact tccacagaga catggaagct ctgaatgttc   1020

tccctccaga tgtcttaacc cgggttagtg agtatgtgcc agaaattgtg aactttgtcc   1080

agaagattgt ggacaacggt tacggctatg tctccaatgg gtctgtctac tttgatacag   1140

cgaagtttgc ttctagcgag aagcactcct atgggaagct ggtgcctgag gccgttggag   1200

atcagaaagc ccttcaagaa ggggaaggtg acctgagcat ctctgcagac cgcctgagtg   1260

agaagcgctc tcccaacgac tttgccttat ggaaggcctc taagcccgga gaaccgtcct   1320

ggccgtgccc ttggggaaag ggtcgtccgg gctggcatat cgagtgctcg gccatggcag   1380

gcaccctcct aggggcttcg atggacattc acggaggtgg gttcgacctc cggttccccc   1440

accatgacaa tgagctggca cagtcggagg cctactttga aaacgactgc tgggtcaggt   1500

acttcctgca cacaggccac ctgaccattg caggctgcaa aatgtcaaag tcactaaaaa   1560

acttcatcac cattaaagat gccttgaaaa agcactcagc acggcagttg cggctggcct   1620

tcctcatgca ctcgtggaag gacaccctgg actactccag caacaccatg gagtcagcgc   1680

ttcaatatga gaagttcttg aatgagtttt tcttaaatgt gaaagatatc cttcgcgctc   1740

ctgttgacat cactggtcag tttgagaagt ggggagaaga agaagcagaa ctgaataaga   1800

acttttatga caagaagaca gcaattcaca aagccctctg tgacaatgtt gacacccgca   1860

ccgtcatgga agagatgcgg gccttggtca gtcagtgcaa cctctatatg gcagcccgga   1920

aagccgtgag gaagaggccc aaccaggctc tgctggagaa catcgccctg tacctcaccc   1980

atatgctgaa gatctttggg gccgtagaag aggacagctc cctgggattc ccggtcggag   2040

ggcctggaac cagcctcagt ctcgaggcca cagtcatgcc ctaccttcag gtgttatcag   2100

aattccgaga aggagtgcgg aagattgccc gagagcaaaa agtccctgag attctgcagc   2160

tcagcgatgc cctgcgggac aacatcctgc ccgagcttgg ggtgcggttt gaagaccacg   2220

aaggactgcc cacagtggtg aaactggtag acagaaacac cttattaaaa gagagagaag   2280

aaaagagacg ggttgaagag gagaagagga agaagaaaga ggaggcggcc cggaggaaac   2340

aggaacaaga agcagcaaag ctggccaaga tgaagattcc ccccagtgag atgttcttgt   2400

cagaaaccga caaatactcc aagtttgatg aaaatggtct gcccacacat gacatggagg   2460

gcaaagagct cagcaaaggg caagccaaga agctgaagaa gctcttcgag gctcaggaga   2520

agctctacaa ggaatatctg cagatggccc agaatggaag cttccagtga gggggcacag   2580

gactgacttt ttaaaccatt gtggactagt ggctgctgtc tgcctcagtg acaatgtccc   2640

agcgctccta tcatgtttac agtcaccctt gggtcctaaa ttaagagttg tgttcatgta   2700

ggttcgtgtc gtcgttggct ctgagacatt gataataaat ttttctcaac agtgagaccc   2760

tctc                                                                2764


<210>  2577
<211>  831
<212>  PRT
<213>  Homo sapiens

<400>  2577


Met Ala Asp Ser Ser Gly Gln Gln Ala Pro Asp Tyr Arg Ser Ile Leu 
1               5                   10                  15      


Ser Ile Ser Asp Glu Ala Ala Arg Ala Gln Ala Leu Asn Glu His Leu 
            20                  25                  30          


Ser Thr Arg Ser Tyr Val Gln Gly Tyr Ser Leu Ser Gln Ala Asp Val 
        35                  40                  45              


Asp Ala Phe Arg Gln Leu Ser Ala Pro Pro Ala Asp Pro Gln Leu Phe 
    50                  55                  60                  


His Val Ala Arg Trp Phe Arg His Ile Glu Ala Leu Leu Gly Ser Pro 
65                  70                  75                  80  


Cys Gly Lys Gly Gln Pro Cys Arg Leu Gln Ala Ser Lys Gly Arg Arg 
                85                  90                  95      


Val Gln Pro Gln Trp Ser Pro Pro Ala Gly Thr Gln Pro Cys Arg Leu 
            100                 105                 110         


His Leu Tyr Asn Ser Leu Thr Arg Asn Lys Glu Val Phe Ile Pro Gln 
        115                 120                 125             


Asp Gly Lys Lys Val Thr Trp Tyr Cys Cys Gly Pro Thr Val Tyr Asp 
    130                 135                 140                 


Ala Ser His Met Gly His Ala Arg Ser Tyr Ile Ser Phe Asp Ile Leu 
145                 150                 155                 160 


Arg Arg Val Leu Lys Asp Tyr Phe Lys Phe Asp Val Phe Tyr Cys Met 
                165                 170                 175     


Asn Ile Thr Asp Ile Asp Asp Lys Ile Ile Lys Arg Ala Arg Gln Asn 
            180                 185                 190         


His Leu Phe Glu Gln Tyr Arg Glu Lys Arg Pro Glu Ala Ala Gln Leu 
        195                 200                 205             


Leu Glu Asp Val Gln Ala Ala Leu Lys Pro Phe Ser Val Lys Leu Asn 
    210                 215                 220                 


Glu Thr Thr Asp Pro Asp Lys Lys Gln Met Leu Glu Arg Ile Gln His 
225                 230                 235                 240 


Ala Val Gln Leu Ala Thr Glu Pro Leu Glu Lys Ala Val Gln Ser Arg 
                245                 250                 255     


Leu Thr Gly Glu Glu Val Asn Ser Cys Val Glu Val Leu Leu Glu Glu 
            260                 265                 270         


Ala Lys Asp Leu Leu Ser Asp Trp Leu Asp Ser Thr Leu Gly Cys Asp 
        275                 280                 285             


Val Thr Asp Asn Ser Ile Phe Ser Lys Leu Pro Lys Phe Trp Glu Gly 
    290                 295                 300                 


Asp Phe His Arg Asp Met Glu Ala Leu Asn Val Leu Pro Pro Asp Val 
305                 310                 315                 320 


Leu Thr Arg Val Ser Glu Tyr Val Pro Glu Ile Val Asn Phe Val Gln 
                325                 330                 335     


Lys Ile Val Asp Asn Gly Tyr Gly Tyr Val Ser Asn Gly Ser Val Tyr 
            340                 345                 350         


Phe Asp Thr Ala Lys Phe Ala Ser Ser Glu Lys His Ser Tyr Gly Lys 
        355                 360                 365             


Leu Val Pro Glu Ala Val Gly Asp Gln Lys Ala Leu Gln Glu Gly Glu 
    370                 375                 380                 


Gly Asp Leu Ser Ile Ser Ala Asp Arg Leu Ser Glu Lys Arg Ser Pro 
385                 390                 395                 400 


Asn Asp Phe Ala Leu Trp Lys Ala Ser Lys Pro Gly Glu Pro Ser Trp 
                405                 410                 415     


Pro Cys Pro Trp Gly Lys Gly Arg Pro Gly Trp His Ile Glu Cys Ser 
            420                 425                 430         


Ala Met Ala Gly Thr Leu Leu Gly Ala Ser Met Asp Ile His Gly Gly 
        435                 440                 445             


Gly Phe Asp Leu Arg Phe Pro His His Asp Asn Glu Leu Ala Gln Ser 
    450                 455                 460                 


Glu Ala Tyr Phe Glu Asn Asp Cys Trp Val Arg Tyr Phe Leu His Thr 
465                 470                 475                 480 


Gly His Leu Thr Ile Ala Gly Cys Lys Met Ser Lys Ser Leu Lys Asn 
                485                 490                 495     


Phe Ile Thr Ile Lys Asp Ala Leu Lys Lys His Ser Ala Arg Gln Leu 
            500                 505                 510         


Arg Leu Ala Phe Leu Met His Ser Trp Lys Asp Thr Leu Asp Tyr Ser 
        515                 520                 525             


Ser Asn Thr Met Glu Ser Ala Leu Gln Tyr Glu Lys Phe Leu Asn Glu 
    530                 535                 540                 


Phe Phe Leu Asn Val Lys Asp Ile Leu Arg Ala Pro Val Asp Ile Thr 
545                 550                 555                 560 


Gly Gln Phe Glu Lys Trp Gly Glu Glu Glu Ala Glu Leu Asn Lys Asn 
                565                 570                 575     


Phe Tyr Asp Lys Lys Thr Ala Ile His Lys Ala Leu Cys Asp Asn Val 
            580                 585                 590         


Asp Thr Arg Thr Val Met Glu Glu Met Arg Ala Leu Val Ser Gln Cys 
        595                 600                 605             


Asn Leu Tyr Met Ala Ala Arg Lys Ala Val Arg Lys Arg Pro Asn Gln 
    610                 615                 620                 


Ala Leu Leu Glu Asn Ile Ala Leu Tyr Leu Thr His Met Leu Lys Ile 
625                 630                 635                 640 


Phe Gly Ala Val Glu Glu Asp Ser Ser Leu Gly Phe Pro Val Gly Gly 
                645                 650                 655     


Pro Gly Thr Ser Leu Ser Leu Glu Ala Thr Val Met Pro Tyr Leu Gln 
            660                 665                 670         


Val Leu Ser Glu Phe Arg Glu Gly Val Arg Lys Ile Ala Arg Glu Gln 
        675                 680                 685             


Lys Val Pro Glu Ile Leu Gln Leu Ser Asp Ala Leu Arg Asp Asn Ile 
    690                 695                 700                 


Leu Pro Glu Leu Gly Val Arg Phe Glu Asp His Glu Gly Leu Pro Thr 
705                 710                 715                 720 


Val Val Lys Leu Val Asp Arg Asn Thr Leu Leu Lys Glu Arg Glu Glu 
                725                 730                 735     


Lys Arg Arg Val Glu Glu Glu Lys Arg Lys Lys Lys Glu Glu Ala Ala 
            740                 745                 750         


Arg Arg Lys Gln Glu Gln Glu Ala Ala Lys Leu Ala Lys Met Lys Ile 
        755                 760                 765             


Pro Pro Ser Glu Met Phe Leu Ser Glu Thr Asp Lys Tyr Ser Lys Phe 
    770                 775                 780                 


Asp Glu Asn Gly Leu Pro Thr His Asp Met Glu Gly Lys Glu Leu Ser 
785                 790                 795                 800 


Lys Gly Gln Ala Lys Lys Leu Lys Lys Leu Phe Glu Ala Gln Glu Lys 
                805                 810                 815     


Leu Tyr Lys Glu Tyr Leu Gln Met Ala Gln Asn Gly Ser Phe Gln 
            820                 825                 830     

<210>  2578
<211>  2811
<212>  DNA
<213>  Homo sapiens

<400>  2578
acttccgggg cggcggttgc atcagattct aggaagtgtc tgtagccgca gctgcgggtc     60

cgggattccc agccatggca gattcctccg ggcagcaggc tcctgactac aggtccattc    120

tgagcattag tgacgaggca gccagggcac aagccctgaa cgagcacctc agcacgcgta    180

gctatgtcca ggggtactca ctgtcccagg cagacgtgga cgcgttcagg cagctctcgg    240

ccccgcccgc tgacccccag ctcttccacg tggctcggtg gttcaggcac atagaagcgc    300

tcctgggtag cccctgtggc aaaggccagc cctgcaggct ccaagcaagc aaaggccggc    360

gtgtgcagcc ccagtggtcc cctcctgctg ggacccagcc atgcagactc cacctttaca    420

acagcctcac caggaacaag tgtttcttgc atttcttgtg atcgtcattc cttcattcct    480

aacaaaggaa gtgttcatac ctcaagatgg gaaaaaggtg acgtggtatt gctgtgggcc    540

aaccgtctat gacgcatctc acatggggca cgccaggtcc tacatctctt ttgatatctt    600

gagaagagtg ttgaaggatt acttcaaatt tgatgtcttt tattgcatga acattacgga    660

tattgatgac aagatcatca agagggcccg gcagaaccac ctgttcgagc agtatcggga    720

gaagaggcct gaagcggcac agctcttgga ggatgttcag gccgccctga agccattttc    780

agtaaaatta aatgagacca cggatcccga taaaaagcag atgctcgaac ggattcagca    840

cgcagtgcag cttgccacag agccacttga gaaagctgtg cagtccagac tcacgggaga    900

ggaagtcaac agctgtgtgg aggtgttgct ggaagaagcc aaggatttgc tctctgactg    960

gctggattct acacttggct gtgatgtcac tgacaattcc atcttctcca agctgcccaa   1020

gttctgggag ggggacttcc acagagacat ggaagctctg aatgttctcc ctccagatgt   1080

cttaacccgg gttagtgagt atgtgccaga aattgtgaac tttgtccaga agattgtgga   1140

caacggttac ggctatgtct ccaatgggtc tgtctacttt gatacagcga agtttgcttc   1200

tagcgagaag cactcctatg ggaagctggt gcctgaggcc gttggagatc agaaagccct   1260

tcaagaaggg gaaggtgacc tgagcatctc tgcagaccgc ctgagtgaga agcgctctcc   1320

caacgacttt gccttatgga aggcctctaa gcccggagaa ccgtcctggc cgtgcccttg   1380

gggaaagggt cgtccgggct ggcatatcga gtgctcggcc atggcaggca ccctcctagg   1440

ggcttcgatg gacattcacg gaggtgggtt cgacctccgg ttcccccacc atgacaatga   1500

gctggcacag tcggaggcct actttgaaaa cgactgctgg gtcaggtact tcctgcacac   1560

aggccacctg accattgcag gctgcaaaat gtcaaagtca ctaaaaaact tcatcaccat   1620

taaagatgcc ttgaaaaagc actcagcacg gcagttgcgg ctggccttcc tcatgcactc   1680

gtggaaggac accctggact actccagcaa caccatggag tcagcgcttc aatatgagaa   1740

gttcttgaat gagtttttct taaatgtgaa agatatcctt cgcgctcctg ttgacatcac   1800

tggtcagttt gagaagtggg gagaagaaga agcagaactg aataagaact tttatgacaa   1860

gaagacagca attcacaaag ccctctgtga caatgttgac acccgcaccg tcatggaaga   1920

gatgcgggcc ttggtcagtc agtgcaacct ctatatggca gcccggaaag ccgtgaggaa   1980

gaggcccaac caggctctgc tggagaacat cgccctgtac ctcacccata tgctgaagat   2040

ctttggggcc gtagaagagg acagctccct gggattcccg gtcggagggc ctggaaccag   2100

cctcagtctc gaggccacag tcatgcccta ccttcaggtg ttatcagaat tccgagaagg   2160

agtgcggaag attgcccgag agcaaaaagt ccctgagatt ctgcagctca gcgatgccct   2220

gcgggacaac atcctgcccg agcttggggt gcggtttgaa gaccacgaag gactgcccac   2280

agtggtgaaa ctggtagaca gaaacacctt attaaaagag agagaagaaa agagacgggt   2340

tgaagaggag aagaggaaga agaaagagga ggcggcccgg aggaaacagg aacaagaagc   2400

agcaaagctg gccaagatga agattccccc cagtgagatg ttcttgtcag aaaccgacaa   2460

atactccaag tttgatgaaa atggtctgcc cacacatgac atggagggca aagagctcag   2520

caaagggcaa gccaagaagc tgaagaagct cttcgaggct caggagaagc tctacaagga   2580

atatctgcag atggcccaga atggaagctt ccagtgaggg ggcacaggac tgacttttta   2640

aaccattgtg gactagtggc tgctgtctgc ctcagtgaca atgtcccagc gctcctatca   2700

tgtttacagt cacccttggg tcctaaatta agagttgtgt tcatgtaggt tcgtgtcgtc   2760

gttggctctg agacattgat aataaatttt tctcaacagt gagaccctct c            2811


<210>  2579
<211>  738
<212>  PRT
<213>  Homo sapiens

<400>  2579


Met Gln Thr Pro Pro Leu Gln Gln Pro His Gln Glu Gln Val Phe Leu 
1               5                   10                  15      


Ala Phe Leu Val Ile Val Ile Pro Ser Phe Leu Thr Lys Glu Val Phe 
            20                  25                  30          


Ile Pro Gln Asp Gly Lys Lys Val Thr Trp Tyr Cys Cys Gly Pro Thr 
        35                  40                  45              


Val Tyr Asp Ala Ser His Met Gly His Ala Arg Ser Tyr Ile Ser Phe 
    50                  55                  60                  


Asp Ile Leu Arg Arg Val Leu Lys Asp Tyr Phe Lys Phe Asp Val Phe 
65                  70                  75                  80  


Tyr Cys Met Asn Ile Thr Asp Ile Asp Asp Lys Ile Ile Lys Arg Ala 
                85                  90                  95      


Arg Gln Asn His Leu Phe Glu Gln Tyr Arg Glu Lys Arg Pro Glu Ala 
            100                 105                 110         


Ala Gln Leu Leu Glu Asp Val Gln Ala Ala Leu Lys Pro Phe Ser Val 
        115                 120                 125             


Lys Leu Asn Glu Thr Thr Asp Pro Asp Lys Lys Gln Met Leu Glu Arg 
    130                 135                 140                 


Ile Gln His Ala Val Gln Leu Ala Thr Glu Pro Leu Glu Lys Ala Val 
145                 150                 155                 160 


Gln Ser Arg Leu Thr Gly Glu Glu Val Asn Ser Cys Val Glu Val Leu 
                165                 170                 175     


Leu Glu Glu Ala Lys Asp Leu Leu Ser Asp Trp Leu Asp Ser Thr Leu 
            180                 185                 190         


Gly Cys Asp Val Thr Asp Asn Ser Ile Phe Ser Lys Leu Pro Lys Phe 
        195                 200                 205             


Trp Glu Gly Asp Phe His Arg Asp Met Glu Ala Leu Asn Val Leu Pro 
    210                 215                 220                 


Pro Asp Val Leu Thr Arg Val Ser Glu Tyr Val Pro Glu Ile Val Asn 
225                 230                 235                 240 


Phe Val Gln Lys Ile Val Asp Asn Gly Tyr Gly Tyr Val Ser Asn Gly 
                245                 250                 255     


Ser Val Tyr Phe Asp Thr Ala Lys Phe Ala Ser Ser Glu Lys His Ser 
            260                 265                 270         


Tyr Gly Lys Leu Val Pro Glu Ala Val Gly Asp Gln Lys Ala Leu Gln 
        275                 280                 285             


Glu Gly Glu Gly Asp Leu Ser Ile Ser Ala Asp Arg Leu Ser Glu Lys 
    290                 295                 300                 


Arg Ser Pro Asn Asp Phe Ala Leu Trp Lys Ala Ser Lys Pro Gly Glu 
305                 310                 315                 320 


Pro Ser Trp Pro Cys Pro Trp Gly Lys Gly Arg Pro Gly Trp His Ile 
                325                 330                 335     


Glu Cys Ser Ala Met Ala Gly Thr Leu Leu Gly Ala Ser Met Asp Ile 
            340                 345                 350         


His Gly Gly Gly Phe Asp Leu Arg Phe Pro His His Asp Asn Glu Leu 
        355                 360                 365             


Ala Gln Ser Glu Ala Tyr Phe Glu Asn Asp Cys Trp Val Arg Tyr Phe 
    370                 375                 380                 


Leu His Thr Gly His Leu Thr Ile Ala Gly Cys Lys Met Ser Lys Ser 
385                 390                 395                 400 


Leu Lys Asn Phe Ile Thr Ile Lys Asp Ala Leu Lys Lys His Ser Ala 
                405                 410                 415     


Arg Gln Leu Arg Leu Ala Phe Leu Met His Ser Trp Lys Asp Thr Leu 
            420                 425                 430         


Asp Tyr Ser Ser Asn Thr Met Glu Ser Ala Leu Gln Tyr Glu Lys Phe 
        435                 440                 445             


Leu Asn Glu Phe Phe Leu Asn Val Lys Asp Ile Leu Arg Ala Pro Val 
    450                 455                 460                 


Asp Ile Thr Gly Gln Phe Glu Lys Trp Gly Glu Glu Glu Ala Glu Leu 
465                 470                 475                 480 


Asn Lys Asn Phe Tyr Asp Lys Lys Thr Ala Ile His Lys Ala Leu Cys 
                485                 490                 495     


Asp Asn Val Asp Thr Arg Thr Val Met Glu Glu Met Arg Ala Leu Val 
            500                 505                 510         


Ser Gln Cys Asn Leu Tyr Met Ala Ala Arg Lys Ala Val Arg Lys Arg 
        515                 520                 525             


Pro Asn Gln Ala Leu Leu Glu Asn Ile Ala Leu Tyr Leu Thr His Met 
    530                 535                 540                 


Leu Lys Ile Phe Gly Ala Val Glu Glu Asp Ser Ser Leu Gly Phe Pro 
545                 550                 555                 560 


Val Gly Gly Pro Gly Thr Ser Leu Ser Leu Glu Ala Thr Val Met Pro 
                565                 570                 575     


Tyr Leu Gln Val Leu Ser Glu Phe Arg Glu Gly Val Arg Lys Ile Ala 
            580                 585                 590         


Arg Glu Gln Lys Val Pro Glu Ile Leu Gln Leu Ser Asp Ala Leu Arg 
        595                 600                 605             


Asp Asn Ile Leu Pro Glu Leu Gly Val Arg Phe Glu Asp His Glu Gly 
    610                 615                 620                 


Leu Pro Thr Val Val Lys Leu Val Asp Arg Asn Thr Leu Leu Lys Glu 
625                 630                 635                 640 


Arg Glu Glu Lys Arg Arg Val Glu Glu Glu Lys Arg Lys Lys Lys Glu 
                645                 650                 655     


Glu Ala Ala Arg Arg Lys Gln Glu Gln Glu Ala Ala Lys Leu Ala Lys 
            660                 665                 670         


Met Lys Ile Pro Pro Ser Glu Met Phe Leu Ser Glu Thr Asp Lys Tyr 
        675                 680                 685             


Ser Lys Phe Asp Glu Asn Gly Leu Pro Thr His Asp Met Glu Gly Lys 
    690                 695                 700                 


Glu Leu Ser Lys Gly Gln Ala Lys Lys Leu Lys Lys Leu Phe Glu Ala 
705                 710                 715                 720 


Gln Glu Lys Leu Tyr Lys Glu Tyr Leu Gln Met Ala Gln Asn Gly Ser 
                725                 730                 735     


Phe Gln 
        

<210>  2580
<211>  2517
<212>  DNA
<213>  Homo sapiens

<400>  2580
cgacttccgg ggcggcggtt gcatcagatt ctaggaagtg tctgtagccg cagctgcggg     60

tccgggattc ccagccatgg cagattcctc cgggcagcag ggcaaaggcc ggcgtgtgca    120

gccccagtgg tcccctcctg ctgggaccca gccatgcaga ctccaccttt acaacagcct    180

caccaggaac aaggaagtgt tcatacctca agatgggaaa aaggtgacgt ggtattgctg    240

tgggccaacc gtctatgacg catctcacat ggggcacgcc aggtcctaca tctcttttga    300

tatcttgaga agagtgttga aggattactt caaatttgat gtcttttatt gcatgaacat    360

tacggatatt gatgacaaga tcatcaagag ggcccggcag aaccacctgt tcgagcagta    420

tcgggagaag aggcctgaag cggcacagct cttggaggat gttcaggccg ccctgaagcc    480

attttcagta aaattaaatg agaccacgga tcccgataaa aagcagatgc tcgaacggat    540

tcagcacgca gtgcagcttg ccacagagcc acttgagaaa gctgtgcagt ccagactcac    600

gggagaggaa gtcaacagct gtgtggaggt gttgctggaa gaagccaagg atttgctctc    660

tgactggctg gattctacac ttggctgtga tgtcactgac aattccatct tctccaagct    720

gcccaagttc tgggaggggg acttccacag agacatggaa gctctgaatg ttctccctcc    780

agatgtctta acccgggtta gtgagtatgt gccagaaatt gtgaactttg tccagaagat    840

tgtggacaac ggttacggct atgtctccaa tgggtctgtc tactttgata cagcgaagtt    900

tgcttctagc gagaagcact cctatgggaa gctggtgcct gaggccgttg gagatcagaa    960

agcccttcaa gaaggggaag gtgacctgag catctctgca gaccgcctga gtgagaagcg   1020

ctctcccaac gactttgcct tatggaaggc ctctaagccc ggagaaccgt cctggccgtg   1080

cccttgggga aagggtcgtc cgggctggca tatcgagtgc tcggccatgg caggcaccct   1140

cctaggggct tcgatggaca ttcacggagg tgggttcgac ctccggttcc cccaccatga   1200

caatgagctg gcacagtcgg aggcctactt tgaaaacgac tgctgggtca ggtacttcct   1260

gcacacaggc cacctgacca ttgcaggctg caaaatgtca aagtcactaa aaaacttcat   1320

caccattaaa gatgccttga aaaagcactc agcacggcag ttgcggctgg ccttcctcat   1380

gcactcgtgg aaggacaccc tggactactc cagcaacacc atggagtcag cgcttcaata   1440

tgagaagttc ttgaatgagt ttttcttaaa tgtgaaagat atccttcgcg ctcctgttga   1500

catcactggt cagtttgaga agtggggaga agaagaagca gaactgaata agaactttta   1560

tgacaagaag acagcaattc acaaagccct ctgtgacaat gttgacaccc gcaccgtcat   1620

ggaagagatg cgggccttgg tcagtcagtg caacctctat atggcagccc ggaaagccgt   1680

gaggaagagg cccaaccagg ctctgctgga gaacatcgcc ctgtacctca cccatatgct   1740

gaagatcttt ggggccgtag aagaggacag ctccctggga ttcccggtcg gagggcctgg   1800

aaccagcctc agtctcgagg ccacagtcat gccctacctt caggtgttat cagaattccg   1860

agaaggagtg cggaagattg cccgagagca aaaagtccct gagattctgc agctcagcga   1920

tgccctgcgg gacaacatcc tgcccgagct tggggtgcgg tttgaagacc acgaaggact   1980

gcccacagtg gtgaaactgg tagacagaaa caccttatta aaagagagag aagaaaagag   2040

acgggttgaa gaggagaaga ggaagaagaa agaggaggcg gcccggagga aacaggaaca   2100

agaagcagca aagctggcca agatgaagat tccccccagt gagatgttct tgtcagaaac   2160

cgacaaatac tccaagtttg atgaaaatgg tctgcccaca catgacatgg agggcaaaga   2220

gctcagcaaa gggcaagcca agaagctgaa gaagctcttc gaggctcagg agaagctcta   2280

caaggaatat ctgcagatgg cccagaatgg aagcttccag tgagggggca caggactgac   2340

tttttaaacc attgtggact agtggctgct gtctgcctca gtgacaatgt cccagcgctc   2400

ctatcatgtt tacagtcacc cttgggtcct aaattaagag ttgtgttcat gtaggttcgt   2460

gtcgtcgttg gctctgagac attgataata aatttttctc aacagtgaga ccctctc      2517


<210>  2581
<211>  748
<212>  PRT
<213>  Homo sapiens

<400>  2581


Met Ala Asp Ser Ser Gly Gln Gln Gly Lys Gly Arg Arg Val Gln Pro 
1               5                   10                  15      


Gln Trp Ser Pro Pro Ala Gly Thr Gln Pro Cys Arg Leu His Leu Tyr 
            20                  25                  30          


Asn Ser Leu Thr Arg Asn Lys Glu Val Phe Ile Pro Gln Asp Gly Lys 
        35                  40                  45              


Lys Val Thr Trp Tyr Cys Cys Gly Pro Thr Val Tyr Asp Ala Ser His 
    50                  55                  60                  


Met Gly His Ala Arg Ser Tyr Ile Ser Phe Asp Ile Leu Arg Arg Val 
65                  70                  75                  80  


Leu Lys Asp Tyr Phe Lys Phe Asp Val Phe Tyr Cys Met Asn Ile Thr 
                85                  90                  95      


Asp Ile Asp Asp Lys Ile Ile Lys Arg Ala Arg Gln Asn His Leu Phe 
            100                 105                 110         


Glu Gln Tyr Arg Glu Lys Arg Pro Glu Ala Ala Gln Leu Leu Glu Asp 
        115                 120                 125             


Val Gln Ala Ala Leu Lys Pro Phe Ser Val Lys Leu Asn Glu Thr Thr 
    130                 135                 140                 


Asp Pro Asp Lys Lys Gln Met Leu Glu Arg Ile Gln His Ala Val Gln 
145                 150                 155                 160 


Leu Ala Thr Glu Pro Leu Glu Lys Ala Val Gln Ser Arg Leu Thr Gly 
                165                 170                 175     


Glu Glu Val Asn Ser Cys Val Glu Val Leu Leu Glu Glu Ala Lys Asp 
            180                 185                 190         


Leu Leu Ser Asp Trp Leu Asp Ser Thr Leu Gly Cys Asp Val Thr Asp 
        195                 200                 205             


Asn Ser Ile Phe Ser Lys Leu Pro Lys Phe Trp Glu Gly Asp Phe His 
    210                 215                 220                 


Arg Asp Met Glu Ala Leu Asn Val Leu Pro Pro Asp Val Leu Thr Arg 
225                 230                 235                 240 


Val Ser Glu Tyr Val Pro Glu Ile Val Asn Phe Val Gln Lys Ile Val 
                245                 250                 255     


Asp Asn Gly Tyr Gly Tyr Val Ser Asn Gly Ser Val Tyr Phe Asp Thr 
            260                 265                 270         


Ala Lys Phe Ala Ser Ser Glu Lys His Ser Tyr Gly Lys Leu Val Pro 
        275                 280                 285             


Glu Ala Val Gly Asp Gln Lys Ala Leu Gln Glu Gly Glu Gly Asp Leu 
    290                 295                 300                 


Ser Ile Ser Ala Asp Arg Leu Ser Glu Lys Arg Ser Pro Asn Asp Phe 
305                 310                 315                 320 


Ala Leu Trp Lys Ala Ser Lys Pro Gly Glu Pro Ser Trp Pro Cys Pro 
                325                 330                 335     


Trp Gly Lys Gly Arg Pro Gly Trp His Ile Glu Cys Ser Ala Met Ala 
            340                 345                 350         


Gly Thr Leu Leu Gly Ala Ser Met Asp Ile His Gly Gly Gly Phe Asp 
        355                 360                 365             


Leu Arg Phe Pro His His Asp Asn Glu Leu Ala Gln Ser Glu Ala Tyr 
    370                 375                 380                 


Phe Glu Asn Asp Cys Trp Val Arg Tyr Phe Leu His Thr Gly His Leu 
385                 390                 395                 400 


Thr Ile Ala Gly Cys Lys Met Ser Lys Ser Leu Lys Asn Phe Ile Thr 
                405                 410                 415     


Ile Lys Asp Ala Leu Lys Lys His Ser Ala Arg Gln Leu Arg Leu Ala 
            420                 425                 430         


Phe Leu Met His Ser Trp Lys Asp Thr Leu Asp Tyr Ser Ser Asn Thr 
        435                 440                 445             


Met Glu Ser Ala Leu Gln Tyr Glu Lys Phe Leu Asn Glu Phe Phe Leu 
    450                 455                 460                 


Asn Val Lys Asp Ile Leu Arg Ala Pro Val Asp Ile Thr Gly Gln Phe 
465                 470                 475                 480 


Glu Lys Trp Gly Glu Glu Glu Ala Glu Leu Asn Lys Asn Phe Tyr Asp 
                485                 490                 495     


Lys Lys Thr Ala Ile His Lys Ala Leu Cys Asp Asn Val Asp Thr Arg 
            500                 505                 510         


Thr Val Met Glu Glu Met Arg Ala Leu Val Ser Gln Cys Asn Leu Tyr 
        515                 520                 525             


Met Ala Ala Arg Lys Ala Val Arg Lys Arg Pro Asn Gln Ala Leu Leu 
    530                 535                 540                 


Glu Asn Ile Ala Leu Tyr Leu Thr His Met Leu Lys Ile Phe Gly Ala 
545                 550                 555                 560 


Val Glu Glu Asp Ser Ser Leu Gly Phe Pro Val Gly Gly Pro Gly Thr 
                565                 570                 575     


Ser Leu Ser Leu Glu Ala Thr Val Met Pro Tyr Leu Gln Val Leu Ser 
            580                 585                 590         


Glu Phe Arg Glu Gly Val Arg Lys Ile Ala Arg Glu Gln Lys Val Pro 
        595                 600                 605             


Glu Ile Leu Gln Leu Ser Asp Ala Leu Arg Asp Asn Ile Leu Pro Glu 
    610                 615                 620                 


Leu Gly Val Arg Phe Glu Asp His Glu Gly Leu Pro Thr Val Val Lys 
625                 630                 635                 640 


Leu Val Asp Arg Asn Thr Leu Leu Lys Glu Arg Glu Glu Lys Arg Arg 
                645                 650                 655     


Val Glu Glu Glu Lys Arg Lys Lys Lys Glu Glu Ala Ala Arg Arg Lys 
            660                 665                 670         


Gln Glu Gln Glu Ala Ala Lys Leu Ala Lys Met Lys Ile Pro Pro Ser 
        675                 680                 685             


Glu Met Phe Leu Ser Glu Thr Asp Lys Tyr Ser Lys Phe Asp Glu Asn 
    690                 695                 700                 


Gly Leu Pro Thr His Asp Met Glu Gly Lys Glu Leu Ser Lys Gly Gln 
705                 710                 715                 720 


Ala Lys Lys Leu Lys Lys Leu Phe Glu Ala Gln Glu Lys Leu Tyr Lys 
                725                 730                 735     


Glu Tyr Leu Gln Met Ala Gln Asn Gly Ser Phe Gln 
            740                 745             

<210>  2582
<211>  712
<212>  DNA
<213>  Homo sapiens

<400>  2582
gaagcggcac agctcttgga ggatgttcag gccgccctga agccattttc agtaaaatta     60

aatgagacca cggatcccga taaaaagcag atgctcgaac ggattcagca cgcagtgcag    120

cttgccacag agccacttga gaaagctgtg cagtccagac tcacgggaga ggaagtcaac    180

agctgtgtgg aggtgttgct ggaagaagcc aaggatttgc tctctgactg gctggattct    240

acacttggct gtgatgtcac tgacaattcc atcttctcca agctgcccaa gttctgggag    300

ggggacttcc acagagacat ggaagctctg aatctatgtc tccaatgggt ctgtctactt    360

tgatacagcg aagtttgctt ctagcgagaa gcactcctat gggaagctgg tgcctgaggc    420

cgttggagat cagaaagccc ttcaagaagg ggaaggtgag gagggcatgc ctgagagcat    480

gtgggctctc cctcctggcc cagcctgggt tgtgttgact ttgcaggcca cgggggctgc    540

gctgagccca cccctcagac tcttgggaac agtgcttttt cacctgaagg aattttagga    600

gttttctgca ctcaacattg tgcagctcta agaccatgac atgtgttttt ttaatggata    660

tataataatt atgcaattta tggggaacat gtgatgtctt aatacatgca ca            712


<210>  2583
<211>  90
<212>  PRT
<213>  Homo sapiens

<400>  2583


Met Leu Glu Arg Ile Gln His Ala Val Gln Leu Ala Thr Glu Pro Leu 
1               5                   10                  15      


Glu Lys Ala Val Gln Ser Arg Leu Thr Gly Glu Glu Val Asn Ser Cys 
            20                  25                  30          


Val Glu Val Leu Leu Glu Glu Ala Lys Asp Leu Leu Ser Asp Trp Leu 
        35                  40                  45              


Asp Ser Thr Leu Gly Cys Asp Val Thr Asp Asn Ser Ile Phe Ser Lys 
    50                  55                  60                  


Leu Pro Lys Phe Trp Glu Gly Asp Phe His Arg Asp Met Glu Ala Leu 
65                  70                  75                  80  


Asn Leu Cys Leu Gln Trp Val Cys Leu Leu 
                85                  90  

<210>  2584
<211>  863
<212>  DNA
<213>  Homo sapiens

<400>  2584
cgacttccgg ggcggcggtt gcatcagatt ctaggaagtg tctgtagccg cagctgcggg     60

tccgggattc ccagccatgg cagattcctc cgggcagcag ggcaaaggcc ggcgtgtgca    120

gccccagtgg tcccctcctg ctgggaccca gccatgcaga ctccaccttt acaacagcct    180

caccaggaac aaggaagtgt tcatacctca agatgggaaa aaggtgacgt ggtattgctg    240

tgggccaacc gtctatgacg catctcacat ggggcacgcc aggtcctaca tctcttttga    300

tatcttgaga agagtgttga aggattactt caaatttgat gtcttttatt gcatgaacat    360

tacggatatt gatgacaaga tcatcaagag ggcccggcag aaccacctgt tcgagcagta    420

tcgggagaag aggcctgaag cggcacagct cttggaggat gttcaggccg ccctgaagcc    480

attttcagta aaattaaatg agaccacgga tcccgataaa aagcagatgc tcgaacggat    540

tcagcacgca gtgcagcttg ccacagagcc acttgagaaa gctgtgcagt ccagactcac    600

gggagaggaa gtcaacagct gtgtggaggt gttgctggaa gaagccaagg atttgctctc    660

tgactggctg gattctacac ttggctgtga tgtcactgac aattccatct tctccaagct    720

gcccaagttc tgggaggggg acttccacag agacatggaa gctctgaatg ttctccctcc    780

agatgtctta acccgggtta gtgagtatgt gccagaaatt gtgaactttg tccagaagat    840

tgtggacaac ggttacgggt aag                                            863


<210>  2585
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  2585


Met Ala Asp Ser Ser Gly Gln Gln Gly Lys Gly Arg Arg Val Gln Pro 
1               5                   10                  15      


Gln Trp Ser Pro Pro Ala Gly Thr Gln Pro Cys Arg Leu His Leu Tyr 
            20                  25                  30          


Asn Ser Leu Thr Arg Asn Lys Glu Val Phe Ile Pro Gln Asp Gly Lys 
        35                  40                  45              


Lys Val Thr Trp Tyr Cys Cys Gly Pro Thr Val Tyr Asp Ala Ser His 
    50                  55                  60                  


Met Gly His Ala Arg Ser Tyr Ile Ser Phe Asp Ile Leu Arg Arg Val 
65                  70                  75                  80  


Leu Lys Asp Tyr Phe Lys Phe Asp Val Phe Tyr Cys Met Asn Ile Thr 
                85                  90                  95      


Asp Ile Asp Asp Lys Ile Ile Lys Arg Ala Arg Gln Asn His Leu Phe 
            100                 105                 110         


Glu Gln Tyr Arg Glu Lys Arg Pro Glu Ala Ala Gln Leu Leu Glu Asp 
        115                 120                 125             


Val Gln Ala Ala Leu Lys Pro Phe Ser Val Lys Leu Asn Glu Thr Thr 
    130                 135                 140                 


Asp Pro Asp Lys Lys Gln Met Leu Glu Arg Ile Gln His Ala Val Gln 
145                 150                 155                 160 


Leu Ala Thr Glu Pro Leu Glu Lys Ala Val Gln Ser Arg Leu Thr Gly 
                165                 170                 175     


Glu Glu Val Asn Ser Cys Val Glu Val Leu Leu Glu Glu Ala Lys Asp 
            180                 185                 190         


Leu Leu Ser Asp Trp Leu Asp Ser Thr Leu Gly Cys Asp Val Thr Asp 
        195                 200                 205             


Asn Ser Ile Phe Ser Lys Leu Pro Lys Phe Trp Glu Gly Asp Phe His 
    210                 215                 220                 


Arg Asp Met Glu Ala Leu Asn Val Leu Pro Pro Asp Val Leu Thr Arg 
225                 230                 235                 240 


Val Ser Glu Tyr Val Pro Glu Ile Val Asn Phe Val Gln Lys Ile Val 
                245                 250                 255     


Asp Asn Gly Tyr Gly 
            260     

<210>  2586
<211>  2664
<212>  DNA
<213>  Homo sapiens

<400>  2586
gtagaatcca gccagtcaga gagcaaatcc ttggcttctt ccagcaacac ctgaagagaa     60

agaaacaaaa atccagcagc gggccacaca cttcacatga gaacatctcg tgcagctggt    120

gtgagcccat cagtgccctg aattcaaagg tgctgacctt gacctgtgaa gagccaccgt    180

ctcctaggga gactgtgatg cttacacaac tggctcggca gggacaaata caagactcta    240

caaatgggca ggtctcacat gaactcagag gagcaaagcc aaggggactg tgggtgcaga    300

ggcaaaaaga ggtgggaggg ccgaggtggg cctggtgagc atgtgcagcc tacctgggcc    360

gtgcagggca gggttatggg cagaggctgg gcaggagcac acagtgtgtc acctacagca    420

caaccccttg gtgcattcag gaaaagattc atgacggaca cagccagagg ttaggagaga    480

taggcagggc actggtccca gaggtctcaa aagccccatc tccctgacgc cattgactga    540

agatgccatc cccacttgac acaccatgga atgggagtaa aaaccaccaa tcccagcaaa    600

acatggcacc tatgtgaacc aggtcctgac cacacacact ctaggcatga gacacgcccc    660

aactgcactc atgtcagaaa agagaaatgt ctaccctccg ccatcttgga gggacctaga    720

gtctcaatgc actgacgtgg acccaggaca gggcgtgaca ccaagcagat ggtctgtggc    780

ctactatggg aaggggaggc aaagaaccaa ggctggagag aaaaagtgta ggaaaatggc    840

ctggcagaca gcaaggacac agggtggaca aagccacaac acagacagag aaggggcaca    900

gggcccacgt gggccaggtt cctgatgcaa tccctgccta cagctcctga atcaaacaga    960

tgtgttaaat gtattgcagg cctgcaagtg gcaaggcacg tctgcaggaa tgagcacacc   1020

ctccccaccg cggcagggca tccagtgggc agacaagcac caaaagcagg gtgtgcgctc   1080

tggggagcaa aggctgccaa gtctgctgcc cgaaaagcaa acactgggcc tgccccaagt   1140

acagggaaac gcgcatcctg gccctcagga tcaccaaggt cacgacccag caagaaccga   1200

catcctaatc gaggtcacca aacacccaag aacatgagca actgtgaatg ggagtcagca   1260

gaaacgacaa acagatggac gcttcagatg gaggagttat cagatacata ataaaatcca   1320

gtaaatatta caggcttaaa gacataagga cggactccca gatgacaggc aatagcaagc   1380

agggacaggc cagcaaagcg gcccagctgg atctgaaaat agaagcaaac ggaacctgca   1440

gagatgaaat ctattaacag gcgaaacagt cttatccatc ctactgagtg actgtttcac   1500

ttcctgtctg aaggagaatt tgtgaacagg aagacagaac tgaagaagtc atccaaaatg   1560

aaacagagac aagaaggaaa attttatgaa agacaggtta ggagacacgg agaaggatga   1620

gatgaaatga tgagactcac atctaattgg caacccagag gagaggagag agggaatcga   1680

gtaaaggtga tacttgaaga cacatctgag aatttctcaa aacccatgca acaatccagc   1740

cccgggaagc acacaaaata tccaatagga taagtaaaaa caaatctctt acaatgtctt   1800

tgtgaaatag cagaaaactg aaaagagaga atacttttat aatgcgcctg atagaaaaga   1860

catatttacc aatcaaagaa aagtaatttg aagggcagcc gatgttttca acaacagcca   1920

acaatggaag ccagaagacg gcaaccacct tgaacaaaca gggaaatata cacacttcaa   1980

gatagacaaa agctgcttcc caccaatact tctaagataa tgtttctaaa acttgcctga   2040

tgatagggct ggaatactca atgttgctgg tcaagcatac agatcaacaa tcaaaatgca   2100

taaatacaaa atgataagag acttctgctt tccagtttca cataagtcag gagcttggaa   2160

gttgccactc tacctaacaa caggtctctg tagcagatct aagatctttg tggacctaag   2220

atcgctgctg tggatcccaa tggctctgac ttctgcgtgc aactgcagaa gctgcaggga   2280

caccccgcgg tggacctacc tggcgtgccc catgtgagat gcgtcataga cggttggccc   2340

acagcaatac cacgtcacct ttttcccatc ttgaggtatg aacacttcct ttgttaggaa   2400

tgaaggaatg acgatcacaa gaaatgcaag aaacactgca caggattacc aaaaacagca   2460

acaaacatca cagtgtggtt tgtgtttagt gtaaacaatt caacagagac cattttgttt   2520

tactgtgaaa agtcacagtc tcagtgggag cccagtgaga tgtacggcac ctcccaccaa   2580

ctgagccctg ggtgggtggg gcctcttcct ccctggggtt ctactcatct atggagggag   2640

gcgataaagg gaatcaatga tttt                                          2664


<210>  2587
<211>  73
<212>  PRT
<213>  Homo sapiens

<400>  2587


Met His Lys Tyr Lys Met Ile Arg Asp Phe Cys Phe Pro Val Ser His 
1               5                   10                  15      


Lys Ser Gly Ala Trp Lys Leu Pro Leu Tyr Leu Thr Thr Gly Leu Cys 
            20                  25                  30          


Ser Arg Ser Lys Ile Phe Val Asp Leu Arg Ser Leu Leu Trp Ile Pro 
        35                  40                  45              


Met Ala Leu Thr Ser Ala Cys Asn Cys Arg Ser Cys Arg Asp Thr Pro 
    50                  55                  60                  


Arg Trp Thr Tyr Leu Ala Cys Pro Met 
65                  70              

<210>  2588
<211>  775
<212>  DNA
<213>  Homo sapiens

<400>  2588
gggagaggag gcagcaccgg gcacggagca caaaacacgt tggatactct tccaagatat     60

cacggctcag gagagtcttc caacggtcct gtaaggttcc tcaacagcag catcagtgcc    120

ataaagtctc ccttccactg agtcctgcta acagcagagg agtgaaaaaa actcatggga    180

caaactgctg tccccacacg tcactgtgtc tgtctgcaaa tgtaggaagg atggggacct    240

gtcccaggga agacagagtc attccgcagt gataaagcag catgtttctg acacaggggt    300

gtctgtgcct atcctcattc ctccctcatc accatcaccg gagcatgctc cttgcatcag    360

ataaacagaa agagaggaat ggaaagccca ttgctcacac atgagtcaca gctattctta    420

agagaatgtt ctccaggcct ttcatgtcct atcactgatt ctcagaactc tgcaaggtca    480

gtgtgaccac cctgctccaa acctaagaaa atggaggctc ccaaaggaag gagaaaattc    540

acccagcgtc acacagcttg caagaggcag agaggaagcc gattccagct ctgcctgcag    600

gaccctctca tcccccctcc gcttcccttc ttgacaaagg gtcttctcca ctctggaggt    660

gccacctgtg ggcacaaagg tctctgggga gatgtggatt cctgaagacc tgcaggggaa    720

ttgggagagg gttttctcac aggatgatcc tatgtagaga ggtgagtttg gcaca         775


<210>  2589
<211>  64
<212>  PRT
<213>  Homo sapiens

<400>  2589


Met Glu Ala Pro Lys Gly Arg Arg Lys Phe Thr Gln Arg His Thr Ala 
1               5                   10                  15      


Cys Lys Arg Gln Arg Gly Ser Arg Phe Gln Leu Cys Leu Gln Asp Pro 
            20                  25                  30          


Leu Ile Pro Pro Pro Leu Pro Phe Leu Thr Lys Gly Leu Leu His Ser 
        35                  40                  45              


Gly Gly Ala Thr Cys Gly His Lys Gly Leu Trp Gly Asp Val Asp Ser 
    50                  55                  60                  

<210>  2590
<211>  1134
<212>  DNA
<213>  Homo sapiens

<400>  2590
cctgccaaca aactggtcac tggaagtctg attgtcctct taacaagcag actaacaggc     60

cggttcctca aggccctggc aaaacgaaga gtgaagagtc actcccactc ccacagctcc    120

ttgtcctggc cactgaagat tgacagagcc cagggccccc ggccccatct gccgtcactg    180

catcggaacc caggcaccac ccactacacc acaattgacc tgaaagatgc cttcttcacc    240

attcccctac accccgattc ccaaaacctc tttgctttca cccagactga ccccaacacc    300

ctccagtcac aacaactcac gtggactgtc ctccctcagg gcttccagga tagccttctt    360

ttcttcgggc aagccctagc ccaagacctt gcctccttgg atctttcccc cagccgcctt    420

cttcaatatc tagatgacct ccttctcttc tttgggccct gcctcttacg tctctgtacc    480

cagtttttac ggaaccgcgt ccgagctttc acccacggaa ccatgaaaga catgacgcta    540

ctgcaagaat accggcaatt tcaaaaccag tcttcaggaa tccacatctc cccagagacc    600

tttgtgccca caggtggcac ctccagagtg gagaagaccc tttgtcaaga agggaagcgg    660

aggggggatg agagggtcct gcaggcagag ctggaatcgg cttcctctct gcctcttgca    720

agctgtgtga cgctgggtga attttctcct tcctttggga gcctccattt tcttaggact    780

cagtggaagg gagactttat ggcactgatg ctgctgttga ggaacctgaa gaaggggaag    840

gtgcaagaga ccatcacctg cagcatgagt gtcctctggg acttcaacta cctactgcac    900

ttgagtgtcc tctgggacct caaccacctc cactcaagtg tcctctggga cctcaaccac    960

ctcctccagt tgagtgtcct ctgggacctc aaccacctcc tccagttgag tgtcctctgg   1020

aacctcaaca accttcttat taaagtttcc tctgggacct caaccacctc ctgcactcaa   1080

gtgccctctg ggacctcatc aacctcctcc actcgactgc cctctgggaa ctga         1134


<210>  2591
<211>  203
<212>  PRT
<213>  Homo sapiens

<400>  2591


Met Lys Asp Met Thr Leu Leu Gln Glu Tyr Arg Gln Phe Gln Asn Gln 
1               5                   10                  15      


Ser Ser Gly Ile His Ile Ser Pro Glu Thr Phe Val Pro Thr Gly Gly 
            20                  25                  30          


Thr Ser Arg Val Glu Lys Thr Leu Cys Gln Glu Gly Lys Arg Arg Gly 
        35                  40                  45              


Asp Glu Arg Val Leu Gln Ala Glu Leu Glu Ser Ala Ser Ser Leu Pro 
    50                  55                  60                  


Leu Ala Ser Cys Val Thr Leu Gly Glu Phe Ser Pro Ser Phe Gly Ser 
65                  70                  75                  80  


Leu His Phe Leu Arg Thr Gln Trp Lys Gly Asp Phe Met Ala Leu Met 
                85                  90                  95      


Leu Leu Leu Arg Asn Leu Lys Lys Gly Lys Val Gln Glu Thr Ile Thr 
            100                 105                 110         


Cys Ser Met Ser Val Leu Trp Asp Phe Asn Tyr Leu Leu His Leu Ser 
        115                 120                 125             


Val Leu Trp Asp Leu Asn His Leu His Ser Ser Val Leu Trp Asp Leu 
    130                 135                 140                 


Asn His Leu Leu Gln Leu Ser Val Leu Trp Asp Leu Asn His Leu Leu 
145                 150                 155                 160 


Gln Leu Ser Val Leu Trp Asn Leu Asn Asn Leu Leu Ile Lys Val Ser 
                165                 170                 175     


Ser Gly Thr Ser Thr Thr Ser Cys Thr Gln Val Pro Ser Gly Thr Ser 
            180                 185                 190         


Ser Thr Ser Ser Thr Arg Leu Pro Ser Gly Asn 
        195                 200             

<210>  2592
<211>  1425
<212>  DNA
<213>  Homo sapiens

<400>  2592
cctgccaaca aactggtcac tggaagtctg attgtcctct taacaagcag actaacaggc     60

cggttcctca aggccctggc aaaacgaaga gtgaagagtc actcccactc ccacagctcc    120

ttgtcctggc cactgaagat tgacagagcc cagggccccc ggccccatct gccgtcactg    180

catcggaacc caggcaccac ccactacacc acaattgacc tgaaagatgc cttcttcacc    240

attcccctac accccgattc ccaaaacctc tttgctttca cccagactga ccccaacacc    300

ctccagtcac aacaactcac gtggactgtc ctccctcagg gcttccagga tagccttctt    360

ttcttcgggc aagccctagc ccaagacctt gcctccttgg atctttcccc cagccgcctt    420

cttcaatatc tagatgacct ccttctctac caccagcagc cacacttccc aaacatttcc    480

tccaagcgtc tcgccaaccc caatgaccag ctattcatag atggctcctc ttccaggccc    540

gctggctcct ccagaattgc tggatatgca gttgtttctc ttgaccaatt tttacggaac    600

cgcgtccgag ctttcaccca cggaaccatg aaagacatga cgctactgca agaataccgg    660

caatttcaaa accaacttgg atacattttc ctcattgcat tttccacgtc cacccttgct    720

catggccgtc gactgtcaga acctaagctt ttcctggccc cattggacct aatctgggac    780

gtcaacggag ctttcggtca aacatctttt ttacctttgt gccctttgtc agaaatggat    840

aaaaggtctt caggaatcca catctcccca gagacctttg tgcccacagg tggcacctcc    900

agagtggaga agaccctttg tcaagaaggg aagcggaggg gggatgagag ggtcctgcag    960

gcagagctgg aatcggcttc ctctctgcct cttgcaagct gtgactcagt ggaagggaga   1020

ctttatggca ctgatgctgc tgttgaggaa cctgaagaag gggaaggtgc aagagaccat   1080

cacctgcagc atgaggtcaa catggctgaa caggagcctc gttctctgtc agaatcgccc   1140

tacttgccct acctcatggc tggcccttcc ggaccattga tgggctgcca gccaccccct   1200

ccacctccgt gtcctctggg acctcaacca ctctctgcaa ctgaaggttt tctgggacct   1260

ctgatacatc ctccactcga acatcctctg ggacctgaaa caccttctcc agctgaagtt   1320

ttactgagaa ctcagatacc tcctccactc aagtttccta atggacctca gcaatgtcct   1380

ccactcgagt gtcccctgga acttcaatca tctcctccac tctag                   1425


<210>  2593
<211>  265
<212>  PRT
<213>  Homo sapiens

<400>  2593


Met Lys Asp Met Thr Leu Leu Gln Glu Tyr Arg Gln Phe Gln Asn Gln 
1               5                   10                  15      


Leu Gly Tyr Ile Phe Leu Ile Ala Phe Ser Thr Ser Thr Leu Ala His 
            20                  25                  30          


Gly Arg Arg Leu Ser Glu Pro Lys Leu Phe Leu Ala Pro Leu Asp Leu 
        35                  40                  45              


Ile Trp Asp Val Asn Gly Ala Phe Gly Gln Thr Ser Phe Leu Pro Leu 
    50                  55                  60                  


Cys Pro Leu Ser Glu Met Asp Lys Arg Ser Ser Gly Ile His Ile Ser 
65                  70                  75                  80  


Pro Glu Thr Phe Val Pro Thr Gly Gly Thr Ser Arg Val Glu Lys Thr 
                85                  90                  95      


Leu Cys Gln Glu Gly Lys Arg Arg Gly Asp Glu Arg Val Leu Gln Ala 
            100                 105                 110         


Glu Leu Glu Ser Ala Ser Ser Leu Pro Leu Ala Ser Cys Asp Ser Val 
        115                 120                 125             


Glu Gly Arg Leu Tyr Gly Thr Asp Ala Ala Val Glu Glu Pro Glu Glu 
    130                 135                 140                 


Gly Glu Gly Ala Arg Asp His His Leu Gln His Glu Val Asn Met Ala 
145                 150                 155                 160 


Glu Gln Glu Pro Arg Ser Leu Ser Glu Ser Pro Tyr Leu Pro Tyr Leu 
                165                 170                 175     


Met Ala Gly Pro Ser Gly Pro Leu Met Gly Cys Gln Pro Pro Pro Pro 
            180                 185                 190         


Pro Pro Cys Pro Leu Gly Pro Gln Pro Leu Ser Ala Thr Glu Gly Phe 
        195                 200                 205             


Leu Gly Pro Leu Ile His Pro Pro Leu Glu His Pro Leu Gly Pro Glu 
    210                 215                 220                 


Thr Pro Ser Pro Ala Glu Val Leu Leu Arg Thr Gln Ile Pro Pro Pro 
225                 230                 235                 240 


Leu Lys Phe Pro Asn Gly Pro Gln Gln Cys Pro Pro Leu Glu Cys Pro 
                245                 250                 255     


Leu Glu Leu Gln Ser Ser Pro Pro Leu 
            260                 265 

<210>  2594
<211>  3593
<212>  DNA
<213>  Homo sapiens

<400>  2594
tggaaactgt ggttataatg tgtcttatgt ccctttttgt ttatactagt tgatgtgttg     60

agcttcttga tttttttgta tttttttctt acttttgaga atttctcagt aattatttcc    120

tttcatacct cagtttctca gtctgttttt catacttcat gtctttttat tggtatcctt    180

attttcctaa ttttacttag tttgctgttt tgccattttt actcattgag cattattcaa    240

atggtaattt tattttcttc agttaattta tgcatctcca tcattttagg gttgatttct    300

gaactttttt tatttctttg attatgccat gtgaccctaa tactttgtac atgtcatctt    360

tgactgagat tcaggcatta acaacaagcc tcctgccaca acctttataa tgtgcctttc    420

tcctggggtc atctaaaaca aataggccca gattctagag gcctcttaag cctgttctgg    480

gatgtgtctt gtgtggaatt gtgtgtgtat ttttcattta aagagggttt ctcagctttc    540

tttgtagtgc cctggaatca cacaatacac ttgtcgcctg gtgctgctgc tgcagccttc    600

ctaccgctgt catgggtatt tcctttcggt ctcagcagac ccagcctgtc actcagagta    660

ccaccatttc tctcagcact ccgtgtcaca gggggcagaa accaatcttt gccaaagctt    720

caaaaggcca aaagtaaaaa cacttgtgcc agtatttgct ttctcttttg aaggagaagc    780

caagagctga gggtgtactc ttaaaggcat gatgctatac tgcggaggag cgggggctgc    840

agtgggtaaa cgtaacagac tgtttttctt cttatctggc tcctagcact gtgctcacct    900

ggggtgctgc aaactgtgaa atggttttta gagttcagat gcatcttctc actagctatg    960

tcttctcatt ttacccaaga ccttctgcca gagcagggca tacaagatgc attcccaaaa   1020

agaatactga gaggatatgg aaattgtggc cttgataatt tatatttaag gaaagactgg   1080

gaaagtttag atgagtgtaa gttgcaaaaa gattataatg gacttaacca atgttcatca   1140

actacccata gcaaaatctt tcaatataat aaatatgtta aaatctttga taacttttca   1200

aatttacata gacgtaatat aagtaatact ggagagaaac ctttcaaatg tcaagaatgt   1260

ggcaaatcct ttcaaatgct ctcattccta actgaacatc agaaaattca cactggaaaa   1320

aaattccaaa aatgtggaga atgtggcaaa acctttatcc agtgctcaca ctttactgaa   1380

cctgagaaca ttgacactgg agagaaacct tacaagtgtc aagaatgtaa caacgtcatt   1440

aaaacttgct cagtccttac taaaaataga atttatgccg gaggggaaca ttacagatgt   1500

gaagaatttg gcaaagtatt taaccagtgc tcccacctta ctgaacatga gcatggtact   1560

gaggaaaaac cctgcaaata tgaagagtgc agcagtgtct ttatctcttg ctcaagcctt   1620

tctaatcaac agatgattct tgctggagag aagctctcca aatgtgaaac atggtacaaa   1680

ggttttaacc acagcccaaa tccttccaaa caccagagaa atgagattgg agggaaacct   1740

ttcaaatgtg aggaatgtga cagcatcttc aagtggttct cagaccttac taaacataag   1800

agaattcaca ctggtgagaa accatacaaa tgtgacgaat gtgggaaagc ctatacacag   1860

tcctcacacc tcagtgaaca caggaggatt cacaccggag agaaacccta ccaatgtgaa   1920

gaatgtggga aggtcttcag aacttgctca agcctttcta accataagag aactcattct   1980

gaagaaaaac cctacacgtg tgaagaatgt ggcaacatct ttaagcagtt atcagacctc   2040

actaagcata agaaaaccca tactggagag aagccctaca aatgtgacga atgtggaaaa   2100

aactttaccc agtcctccaa ccttattgta cataagagaa ttcatactgg agagaaaccc   2160

tacaagtgtg aagaatgtgg cagagtcttc atgtggttct cagacattac caaacataag   2220

aaaacccata ctggagagaa accctacaaa tgtgacgaat gtggaaaaaa ctttacccag   2280

tcctcaaacc ttattgtaca taagagaatt catactggag agaaacccta caagtgtgaa   2340

aagtgtggca aagccttcac ccagttctca cacctgactg tacatgaaag cattcatact   2400

tgagaaaaaa ataaacaaat ataaaaatag gcaaagccgt tagtatctgc tcgcatccca   2460

ctttacatca gagttcagac ttaataaagt tatcataaat gtaattacta ttgaaagacc   2520

tttcatgaaa tataagtctc cagagcacac aagagtattt cttctgaaaa aaatgttaca   2580

attatactag atggaagact tgcatcagtt gcttaaactt tcagaaaatt tgtagagaaa   2640

cccaacaaat ctcataaatg tggaataaca tttgttcaaa aatgatagct tagaaaacac   2700

tagagttcat actaaaagat attttgcaaa tacactaaat gggaaaaata agcaaggaca   2760

cgttcagaaa tgacactgaa tccctgtgtt gagtctacag agacatctag acttaaaata   2820

gatcatttat atttaagttt aaaaggagga tgagactgag tttttgtaga gttataatta   2880

cattcaaaat atactttttt gcattgaaaa aatgttaaat ttttgaaaag cgaatattga   2940

tgtcattcta ttctcaaatc agtagatgct gtgtcttcat ttctagtgct gatgtgaaaa   3000

cacatggtca gttgttgctg cgtcagagat atgagaaatt cttttctctt aggtgtgcat   3060

cactgatata cttgtccgtg aaaggtgaaa gacactgaaa tgtaagatgc gtgagtaaaa   3120

tcttggtaga gaggctcttt gtggttgttt tatatacttg taagtgattt atgagatagg   3180

tgtttagaat aatactcttc tgttagggtc accctgatca gaccgttccc ttcccctccc   3240

acaggactta caatacggtc ccttgtgctc tctgcacagc taccccaggg caaaaaacaa   3300

accccccttc actgatccct ccagtaactg tgcagacagt tacaggatgc ggttaacatg   3360

tctgttcacc tcgcataaca aagctggcaa aaaacatctc caggatgcag acaagacacc   3420

tgcaccctcg actaagctcc cccaccccaa cccagttctc ctgcaccccc aactcagctc   3480

ccgcaccccg acctagttct ggccctataa aaacctgcta tagtctgtaa gcagggctgc   3540

ctcctctaac tgtggtggag cagccaagca gctcaataaa gcttgcttgc ctg          3593


<210>  2595
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  2595


Met Val Phe Arg Val Gln Met His Leu Leu Thr Ser Tyr Val Phe Ser 
1               5                   10                  15      


Phe Tyr Pro Arg Pro Ser Ala Arg Ala Gly His Thr Arg Cys Ile Pro 
            20                  25                  30          


Lys Lys Asn Thr Glu Arg Ile Trp Lys Leu Trp Pro 
        35                  40                  

<210>  2596
<211>  3084
<212>  DNA
<213>  Homo sapiens

<400>  2596
cagctgtagt ttgatcttag tttggtttta aattatttag catatgcctt ttgattgagt     60

agtttagttc ctaaataagc aatttactga aatgaaaaga tgtactttag ccattgtatt    120

ttttttactt gattcttgta gctttttctt tctctctttc ctttttgtgt cttgtacttt    180

gtataataag ctttgactct ttttaaattt tcttttgtgt gtcttatagg tattttcttt    240

gtggttacca tggaaattat ataaaacatc ttaaagttac aacaaggtat tttacactga    300

gatgggattt caccatgcta ctcaggcttg tcttgaactc ctgggctcaa gcgatctgcc    360

tgcctcagcc tcccaaagtg ctgggattac aggtgtgaac caccgtgccc agccaggcct    420

caatgtttct gtggacaaat tcactgctat gtcttctcat tttacccaag accttctgcc    480

agagcagggc atacaagatg cattcccaaa aagaatactg agaggatatg gaaattgtgg    540

ccttgataat ttatatttaa ggaaagactg ggaaagttta gatgagtgta agttgcaaaa    600

agattataat ggacttaacc aatgttcatc aactacccat agcaaaatct ttcaatataa    660

taaatatgtt aaaatctttg ataacttttc aaatttacat agacgtaata taagtaatac    720

tggagagaaa cctttcaaat gtcaagaatg tggcaaatcc tttcaaatgc tctcattcct    780

aactgaacat cagaaaattc acactggaaa aaaattccaa aaatgtggag aatgtggcaa    840

aacctttatc cagtgctcac actttactga acctgagaac attgacactg gagagaaacc    900

ttacaagtgt caagaatgta acaacgtcat taaaacttgc tcagtcctta ctaaaaatag    960

aatttatgcc ggaggggaac attacagatg tgaagaattt ggcaaagtat ttaaccagtg   1020

ctcccacctt actgaacatg agcatggtac tgaggaaaaa ccctgcaaat atgaagagtg   1080

cagcagtgtc tttatctctt gctcaagcct ttctaatcaa cagatgattc ttgctggaga   1140

gaagctctcc aaatgtgaaa catggtacaa aggttttaac cacagcccaa atccttccaa   1200

acaccagaga aatgagattg gagggaaacc tttcaaatgt gaggaatgtg acagcatctt   1260

caagtggttc tcagacctta ctaaacataa gagaattcac actggtgaga aaccatacaa   1320

atgtgacgaa tgtgggaaag cctatacaca gtcctcacac ctcagtgaac acaggaggat   1380

tcacaccgga gagaaaccct accaatgtga agaatgtggg aaggtcttca gaacttgctc   1440

aagcctttct aaccataaga gaactcattc tgaagaaaaa ccctacacgt gtgaagaatg   1500

tggcaacatc tttaagcagt tatcagacct cactaagcat aagaaaaccc atactggaga   1560

gaagccctac aaatgtgacg aatgtggaaa aaactttacc cagtcctcca accttattgt   1620

acataagaga attcatactg gagagaaacc ctacaagtgt gaagaatgtg gcagagtctt   1680

catgtggttc tcagacatta ccaaacataa gaaaacccat actggagaga aaccctacaa   1740

atgtgacgaa tgtggaaaaa actttaccca gtcctcaaac cttattgtac ataagagaat   1800

tcatactgga gagaaaccct acaagtgtga aaagtgtggc aaagccttca cccagttctc   1860

acacctgact gtacatgaaa gcattcatac ttgagaaaaa aataaacaaa tataaaaata   1920

ggcaaagccg ttagtatctg ctcgcatccc actttacatc agagttcaga cttaataaag   1980

ttatcataaa tgtaattact attgaaagac ctttcatgaa atataagtct ccagagcaca   2040

caagagtatt tcttctgaaa aaaatgttac aattatacta gatggaagac ttgcatcagt   2100

tgcttaaact ttcagaaaat ttgtagagaa acccaacaaa tctcataaat gtggaataac   2160

atttgttcaa aaatgatagc ttagaaaaca ctagagttca tactaaaaga tattttgcaa   2220

atacactaaa tgggaaaaat aagcaaggac acgttcagaa atgacactga atccctgtgt   2280

tgagtctaca gagacatcta gacttaaaat agatcattta tatttaagtt taaaaggagg   2340

atgagactga gtttttgtag agttataatt acattcaaaa tatacttttt tgcattgaaa   2400

aaatgttaaa tttttgaaaa gcgaatattg atgtcattct attctcaaat cagtagatgc   2460

tgtgtcttca tttctagtgc tgatgtgaaa acacatggtc agttgttgct gcgtcagaga   2520

tatgagaaat tcttttctct taggtgtgca tcactgatat acttgtccgt gaaaggtgaa   2580

agacactgaa atgtaagatg cgtgagtaaa atcttggtag agaggctctt tgtggttgtt   2640

ttatatactt gtaagtgatt tatgagatag gtgtttagaa taatactctt ctgttagggt   2700

caccctgatc agaccgttcc cttcccctcc cacaggactt acaatacggt cccttgtgct   2760

ctctgcacag ctaccccagg gcaaaaaaca aacccccctt cactgatccc tccagtaact   2820

gtgcagacag ttacaggatg cggttaacat gtctgttcac ctcgcataac aaagctggca   2880

aaaaacatct ccaggatgca gacaagacac ctgcaccctc gactaagctc ccccacccca   2940

acccagttct cctgcacccc caactcagct cccgcacccc gacctagttc tggccctata   3000

aaaacctgct atagtctgta agcagggctg cctcctctaa ctgtggtgga gcagccaagc   3060

agctcaataa agcttgcttg cctg                                          3084


<210>  2597
<211>  530
<212>  PRT
<213>  Homo sapiens

<400>  2597


Met Gly Phe His His Ala Thr Gln Ala Cys Leu Glu Leu Leu Gly Ser 
1               5                   10                  15      


Ser Asp Leu Pro Ala Ser Ala Ser Gln Ser Ala Gly Ile Thr Gly Val 
            20                  25                  30          


Asn His Arg Ala Gln Pro Gly Leu Asn Val Ser Val Asp Lys Phe Thr 
        35                  40                  45              


Ala Met Ser Ser His Phe Thr Gln Asp Leu Leu Pro Glu Gln Gly Ile 
    50                  55                  60                  


Gln Asp Ala Phe Pro Lys Arg Ile Leu Arg Gly Tyr Gly Asn Cys Gly 
65                  70                  75                  80  


Leu Asp Asn Leu Tyr Leu Arg Lys Asp Trp Glu Ser Leu Asp Glu Cys 
                85                  90                  95      


Lys Leu Gln Lys Asp Tyr Asn Gly Leu Asn Gln Cys Ser Ser Thr Thr 
            100                 105                 110         


His Ser Lys Ile Phe Gln Tyr Asn Lys Tyr Val Lys Ile Phe Asp Asn 
        115                 120                 125             


Phe Ser Asn Leu His Arg Arg Asn Ile Ser Asn Thr Gly Glu Lys Pro 
    130                 135                 140                 


Phe Lys Cys Gln Glu Cys Gly Lys Ser Phe Gln Met Leu Ser Phe Leu 
145                 150                 155                 160 


Thr Glu His Gln Lys Ile His Thr Gly Lys Lys Phe Gln Lys Cys Gly 
                165                 170                 175     


Glu Cys Gly Lys Thr Phe Ile Gln Cys Ser His Phe Thr Glu Pro Glu 
            180                 185                 190         


Asn Ile Asp Thr Gly Glu Lys Pro Tyr Lys Cys Gln Glu Cys Asn Asn 
        195                 200                 205             


Val Ile Lys Thr Cys Ser Val Leu Thr Lys Asn Arg Ile Tyr Ala Gly 
    210                 215                 220                 


Gly Glu His Tyr Arg Cys Glu Glu Phe Gly Lys Val Phe Asn Gln Cys 
225                 230                 235                 240 


Ser His Leu Thr Glu His Glu His Gly Thr Glu Glu Lys Pro Cys Lys 
                245                 250                 255     


Tyr Glu Glu Cys Ser Ser Val Phe Ile Ser Cys Ser Ser Leu Ser Asn 
            260                 265                 270         


Gln Gln Met Ile Leu Ala Gly Glu Lys Leu Ser Lys Cys Glu Thr Trp 
        275                 280                 285             


Tyr Lys Gly Phe Asn His Ser Pro Asn Pro Ser Lys His Gln Arg Asn 
    290                 295                 300                 


Glu Ile Gly Gly Lys Pro Phe Lys Cys Glu Glu Cys Asp Ser Ile Phe 
305                 310                 315                 320 


Lys Trp Phe Ser Asp Leu Thr Lys His Lys Arg Ile His Thr Gly Glu 
                325                 330                 335     


Lys Pro Tyr Lys Cys Asp Glu Cys Gly Lys Ala Tyr Thr Gln Ser Ser 
            340                 345                 350         


His Leu Ser Glu His Arg Arg Ile His Thr Gly Glu Lys Pro Tyr Gln 
        355                 360                 365             


Cys Glu Glu Cys Gly Lys Val Phe Arg Thr Cys Ser Ser Leu Ser Asn 
    370                 375                 380                 


His Lys Arg Thr His Ser Glu Glu Lys Pro Tyr Thr Cys Glu Glu Cys 
385                 390                 395                 400 


Gly Asn Ile Phe Lys Gln Leu Ser Asp Leu Thr Lys His Lys Lys Thr 
                405                 410                 415     


His Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly Lys Asn Phe 
            420                 425                 430         


Thr Gln Ser Ser Asn Leu Ile Val His Lys Arg Ile His Thr Gly Glu 
        435                 440                 445             


Lys Pro Tyr Lys Cys Glu Glu Cys Gly Arg Val Phe Met Trp Phe Ser 
    450                 455                 460                 


Asp Ile Thr Lys His Lys Lys Thr His Thr Gly Glu Lys Pro Tyr Lys 
465                 470                 475                 480 


Cys Asp Glu Cys Gly Lys Asn Phe Thr Gln Ser Ser Asn Leu Ile Val 
                485                 490                 495     


His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Lys Cys 
            500                 505                 510         


Gly Lys Ala Phe Thr Gln Phe Ser His Leu Thr Val His Glu Ser Ile 
        515                 520                 525             


His Thr 
    530 

<210>  2598
<211>  3462
<212>  DNA
<213>  Homo sapiens

<400>  2598
cttttcataa tgattgtagt gcattttctg tgaaatgtta ctgctgtcca ctgcatgcca     60

gtgactcaaa atacctagtt ttcatgacta cacagtcaca gttgaatact gtagttatct    120

aggcaaattc ttttttaatg gtacatcaat gtttcatagc agattttatg actaacatct    180

cttagtgttt tgtaattcca tattactgtt tttatggttg aataatattc cttgtatgta    240

tataccacat tttttctgtg tgttcatcac ttgaggcttc ccccatttga cttttctgaa    300

tagtggtaca gtaaacatgg gtgtgcaaat atctcttcta agtcctgagt tgctttgtat    360

acttttgata tagatctaga aatgggattg ctggatcata taattccatt tttaattttt    420

ttaagaaaat tatgcttttt tttttttttt tacacagagt ttcactctat cacccaggct    480

gtagtgcagt ggtgccatct cagctcactg caacctctgc ttcctgggct cgagccttct    540

tcccacttca gcctcctgag gacctggaac tacaggggca caccgccaca cccagctaac    600

ttttgtgttt ttaatagaga cagggttttg ccatgttgcc caggctggtc tcggactcct    660

gggctcaagt gatccacccg cctcggtctc ccgaagtgct ggggttccag gtgtgagctg    720

gtgtgaacca gtgtgcccgg cctatgctat ctttcatcgt ggctgcatcc tttctttcct    780

accagcaggt tacgtggttt tcaatgtctt cacatccttg acagctatgt cttctcattt    840

tacccaagac cttctgccag agcagggcat acaagatgca ttcccaaaaa gaatactgag    900

aggatatgga aattgtggcc ttgataattt atatttaagg aaagactggg aaagtttaga    960

tgagtgtaag ttgcaaaaag attataatgg acttaaccaa tgttcatcaa ctacccatag   1020

caaaatcttt caatataata aatatgttaa aatctttgat aacttttcaa atttacatag   1080

acgtaatata agtaatactg gagagaaacc tttcaaatgt caagaatgtg gcaaatcctt   1140

tcaaatgctc tcattcctaa ctgaacatca gaaaattcac actggaaaaa aattccaaaa   1200

atgtggagaa tgtggcaaaa cctttatcca gtgctcacac tttactgaac ctgagaacat   1260

tgacactgga gagaaacctt acaagtgtca agaatgtaac aacgtcatta aaacttgctc   1320

agtccttact aaaaatagaa tttatgccgg aggggaacat tacagatgtg aagaatttgg   1380

caaagtattt aaccagtgct cccaccttac tgaacatgag catggtactg aggaaaaacc   1440

ctgcaaatat gaagagtgca gcagtgtctt tatctcttgc tcaagccttt ctaatcaaca   1500

gatgattctt gctggagaga agctctccaa atgtgaaaca tggtacaaag gttttaacca   1560

cagcccaaat ccttccaaac accagagaaa tgagattgga gggaaacctt tcaaatgtga   1620

ggaatgtgac agcatcttca agtggttctc agaccttact aaacataaga gaattcacac   1680

tggtgagaaa ccatacaaat gtgacgaatg tgggaaagcc tatacacagt cctcacacct   1740

cagtgaacac aggaggattc acaccggaga gaaaccctac caatgtgaag aatgtgggaa   1800

ggtcttcaga acttgctcaa gcctttctaa ccataagaga actcattctg aagaaaaacc   1860

ctacacgtgt gaagaatgtg gcaacatctt taagcagtta tcagacctca ctaagcataa   1920

gaaaacccat actggagaga agccctacaa atgtgacgaa tgtggaaaaa actttaccca   1980

gtcctccaac cttattgtac ataagagaat tcatactgga gagaaaccct acaagtgtga   2040

agaatgtggc agagtcttca tgtggttctc agacattacc aaacataaga aaacccatac   2100

tggagagaaa ccctacaaat gtgacgaatg tggaaaaaac tttacccagt cctcaaacct   2160

tattgtacat aagagaattc atactggaga gaaaccctac aagtgtgaaa agtgtggcaa   2220

agccttcacc cagttctcac acctgactgt acatgaaagc attcatactt gagaaaaaaa   2280

taaacaaata taaaaatagg caaagccgtt agtatctgct cgcatcccac tttacatcag   2340

agttcagact taataaagtt atcataaatg taattactat tgaaagacct ttcatgaaat   2400

ataagtctcc agagcacaca agagtatttc ttctgaaaaa aatgttacaa ttatactaga   2460

tggaagactt gcatcagttg cttaaacttt cagaaaattt gtagagaaac ccaacaaatc   2520

tcataaatgt ggaataacat ttgttcaaaa atgatagctt agaaaacact agagttcata   2580

ctaaaagata ttttgcaaat acactaaatg ggaaaaataa gcaaggacac gttcagaaat   2640

gacactgaat ccctgtgttg agtctacaga gacatctaga cttaaaatag atcatttata   2700

tttaagttta aaaggaggat gagactgagt ttttgtagag ttataattac attcaaaata   2760

tacttttttg cattgaaaaa atgttaaatt tttgaaaagc gaatattgat gtcattctat   2820

tctcaaatca gtagatgctg tgtcttcatt tctagtgctg atgtgaaaac acatggtcag   2880

ttgttgctgc gtcagagata tgagaaattc ttttctctta ggtgtgcatc actgatatac   2940

ttgtccgtga aaggtgaaag acactgaaat gtaagatgcg tgagtaaaat cttggtagag   3000

aggctctttg tggttgtttt atatacttgt aagtgattta tgagataggt gtttagaata   3060

atactcttct gttagggtca ccctgatcag accgttccct tcccctccca caggacttac   3120

aatacggtcc cttgtgctct ctgcacagct accccagggc aaaaaacaaa ccccccttca   3180

ctgatccctc cagtaactgt gcagacagtt acaggatgcg gttaacatgt ctgttcacct   3240

cgcataacaa agctggcaaa aaacatctcc aggatgcaga caagacacct gcaccctcga   3300

ctaagctccc ccaccccaac ccagttctcc tgcaccccca actcagctcc cgcaccccga   3360

cctagttctg gccctataaa aacctgctat agtctgtaag cagggctgcc tcctctaact   3420

gtggtggagc agccaagcag ctcaataaag cttgcttgcc tg                      3462


<210>  2599
<211>  481
<212>  PRT
<213>  Homo sapiens

<400>  2599


Met Ser Ser His Phe Thr Gln Asp Leu Leu Pro Glu Gln Gly Ile Gln 
1               5                   10                  15      


Asp Ala Phe Pro Lys Arg Ile Leu Arg Gly Tyr Gly Asn Cys Gly Leu 
            20                  25                  30          


Asp Asn Leu Tyr Leu Arg Lys Asp Trp Glu Ser Leu Asp Glu Cys Lys 
        35                  40                  45              


Leu Gln Lys Asp Tyr Asn Gly Leu Asn Gln Cys Ser Ser Thr Thr His 
    50                  55                  60                  


Ser Lys Ile Phe Gln Tyr Asn Lys Tyr Val Lys Ile Phe Asp Asn Phe 
65                  70                  75                  80  


Ser Asn Leu His Arg Arg Asn Ile Ser Asn Thr Gly Glu Lys Pro Phe 
                85                  90                  95      


Lys Cys Gln Glu Cys Gly Lys Ser Phe Gln Met Leu Ser Phe Leu Thr 
            100                 105                 110         


Glu His Gln Lys Ile His Thr Gly Lys Lys Phe Gln Lys Cys Gly Glu 
        115                 120                 125             


Cys Gly Lys Thr Phe Ile Gln Cys Ser His Phe Thr Glu Pro Glu Asn 
    130                 135                 140                 


Ile Asp Thr Gly Glu Lys Pro Tyr Lys Cys Gln Glu Cys Asn Asn Val 
145                 150                 155                 160 


Ile Lys Thr Cys Ser Val Leu Thr Lys Asn Arg Ile Tyr Ala Gly Gly 
                165                 170                 175     


Glu His Tyr Arg Cys Glu Glu Phe Gly Lys Val Phe Asn Gln Cys Ser 
            180                 185                 190         


His Leu Thr Glu His Glu His Gly Thr Glu Glu Lys Pro Cys Lys Tyr 
        195                 200                 205             


Glu Glu Cys Ser Ser Val Phe Ile Ser Cys Ser Ser Leu Ser Asn Gln 
    210                 215                 220                 


Gln Met Ile Leu Ala Gly Glu Lys Leu Ser Lys Cys Glu Thr Trp Tyr 
225                 230                 235                 240 


Lys Gly Phe Asn His Ser Pro Asn Pro Ser Lys His Gln Arg Asn Glu 
                245                 250                 255     


Ile Gly Gly Lys Pro Phe Lys Cys Glu Glu Cys Asp Ser Ile Phe Lys 
            260                 265                 270         


Trp Phe Ser Asp Leu Thr Lys His Lys Arg Ile His Thr Gly Glu Lys 
        275                 280                 285             


Pro Tyr Lys Cys Asp Glu Cys Gly Lys Ala Tyr Thr Gln Ser Ser His 
    290                 295                 300                 


Leu Ser Glu His Arg Arg Ile His Thr Gly Glu Lys Pro Tyr Gln Cys 
305                 310                 315                 320 


Glu Glu Cys Gly Lys Val Phe Arg Thr Cys Ser Ser Leu Ser Asn His 
                325                 330                 335     


Lys Arg Thr His Ser Glu Glu Lys Pro Tyr Thr Cys Glu Glu Cys Gly 
            340                 345                 350         


Asn Ile Phe Lys Gln Leu Ser Asp Leu Thr Lys His Lys Lys Thr His 
        355                 360                 365             


Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly Lys Asn Phe Thr 
    370                 375                 380                 


Gln Ser Ser Asn Leu Ile Val His Lys Arg Ile His Thr Gly Glu Lys 
385                 390                 395                 400 


Pro Tyr Lys Cys Glu Glu Cys Gly Arg Val Phe Met Trp Phe Ser Asp 
                405                 410                 415     


Ile Thr Lys His Lys Lys Thr His Thr Gly Glu Lys Pro Tyr Lys Cys 
            420                 425                 430         


Asp Glu Cys Gly Lys Asn Phe Thr Gln Ser Ser Asn Leu Ile Val His 
        435                 440                 445             


Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Lys Cys Gly 
    450                 455                 460                 


Lys Ala Phe Thr Gln Phe Ser His Leu Thr Val His Glu Ser Ile His 
465                 470                 475                 480 


Thr 
    

<210>  2600
<211>  2958
<212>  DNA
<213>  Homo sapiens

<400>  2600
actctactaa gcacagtaca aggttgataa ttggagaatt tcagcaagag taatgtcact     60

tttttctaat aaaacaggtc tcactgtctg taagccaggc ctgatcacct gcctggagca    120

acgaaaagag ccctggaatg tgaagagaca ggaggcagca gacggacatc cagagatggg    180

atttcaccat gctactcagg cttgtcttga actcctgggc tcaagcgatc tgcctgcctc    240

agcctcccaa agtgctggga ttacaggtgt gaaccaccgt gcccagccag gcctcaatgt    300

ttctgtggac aaattcactg ctatgtcttc tcattttacc caagaccttc tgccagagca    360

gggcatacaa gatgcattcc caaaaagaat actgagagga tatggaaatt gtggccttga    420

taatttatat ttaaggaaag actgggaaag tttagatgag tgtaagttgc aaaaagatta    480

taatggactt aaccaatgtt catcaactac ccatagcaaa atctttcaat ataataaata    540

tgttaaaatc tttgataact tttcaaattt acatagacgt aatataagta atactggaga    600

gaaacctttc aaatgtcaag aatgtggcaa atcctttcaa atgctctcat tcctaactga    660

acatcagaaa attcacactg gaaaaaaatt ccaaaaatgt ggagaatgtg gcaaaacctt    720

tatccagtgc tcacacttta ctgaacctga gaacattgac actggagaga aaccttacaa    780

gtgtcaagaa tgtaacaacg tcattaaaac ttgctcagtc cttactaaaa atagaattta    840

tgccggaggg gaacattaca gatgtgaaga atttggcaaa gtatttaacc agtgctccca    900

ccttactgaa catgagcatg gtactgagga aaaaccctgc aaatatgaag agtgcagcag    960

tgtctttatc tcttgctcaa gcctttctaa tcaacagatg attcttgctg gagagaagct   1020

ctccaaatgt gaaacatggt acaaaggttt taaccacagc ccaaatcctt ccaaacacca   1080

gagaaatgag attggaggga aacctttcaa atgtgaggaa tgtgacagca tcttcaagtg   1140

gttctcagac cttactaaac ataagagaat tcacactggt gagaaaccat acaaatgtga   1200

cgaatgtggg aaagcctata cacagtcctc acacctcagt gaacacagga ggattcacac   1260

cggagagaaa ccctaccaat gtgaagaatg tgggaaggtc ttcagaactt gctcaagcct   1320

ttctaaccat aagagaactc attctgaaga aaaaccctac acgtgtgaag aatgtggcaa   1380

catctttaag cagttatcag acctcactaa gcataagaaa acccatactg gagagaagcc   1440

ctacaaatgt gacgaatgtg gaaaaaactt tacccagtcc tccaacctta ttgtacataa   1500

gagaattcat actggagaga aaccctacaa gtgtgaagaa tgtggcagag tcttcatgtg   1560

gttctcagac attaccaaac ataagaaaac ccatactgga gagaaaccct acaaatgtga   1620

cgaatgtgga aaaaacttta cccagtcctc aaaccttatt gtacataaga gaattcatac   1680

tggagagaaa ccctacaagt gtgaaaagtg tggcaaagcc ttcacccagt tctcacacct   1740

gactgtacat gaaagcattc atacttgaga aaaaaataaa caaatataaa aataggcaaa   1800

gccgttagta tctgctcgca tcccacttta catcagagtt cagacttaat aaagttatca   1860

taaatgtaat tactattgaa agacctttca tgaaatataa gtctccagag cacacaagag   1920

tatttcttct gaaaaaaatg ttacaattat actagatgga agacttgcat cagttgctta   1980

aactttcaga aaatttgtag agaaacccaa caaatctcat aaatgtggaa taacatttgt   2040

tcaaaaatga tagcttagaa aacactagag ttcatactaa aagatatttt gcaaatacac   2100

taaatgggaa aaataagcaa ggacacgttc agaaatgaca ctgaatccct gtgttgagtc   2160

tacagagaca tctagactta aaatagatca tttatattta agtttaaaag gaggatgaga   2220

ctgagttttt gtagagttat aattacattc aaaatatact tttttgcatt gaaaaaatgt   2280

taaatttttg aaaagcgaat attgatgtca ttctattctc aaatcagtag atgctgtgtc   2340

ttcatttcta gtgctgatgt gaaaacacat ggtcagttgt tgctgcgtca gagatatgag   2400

aaattctttt ctcttaggtg tgcatcactg atatacttgt ccgtgaaagg tgaaagacac   2460

tgaaatgtaa gatgcgtgag taaaatcttg gtagagaggc tctttgtggt tgttttatat   2520

acttgtaagt gatttatgag ataggtgttt agaataatac tcttctgtta gggtcaccct   2580

gatcagaccg ttcccttccc ctcccacagg acttacaata cggtcccttg tgctctctgc   2640

acagctaccc cagggcaaaa aacaaacccc ccttcactga tccctccagt aactgtgcag   2700

acagttacag gatgcggtta acatgtctgt tcacctcgca taacaaagct ggcaaaaaac   2760

atctccagga tgcagacaag acacctgcac cctcgactaa gctcccccac cccaacccag   2820

ttctcctgca cccccaactc agctcccgca ccccgaccta gttctggccc tataaaaacc   2880

tgctatagtc tgtaagcagg gctgcctcct ctaactgtgg tggagcagcc aagcagctca   2940

ataaagcttg cttgcctg                                                 2958


<210>  2601
<211>  571
<212>  PRT
<213>  Homo sapiens

<400>  2601


Met Ser Leu Phe Ser Asn Lys Thr Gly Leu Thr Val Cys Lys Pro Gly 
1               5                   10                  15      


Leu Ile Thr Cys Leu Glu Gln Arg Lys Glu Pro Trp Asn Val Lys Arg 
            20                  25                  30          


Gln Glu Ala Ala Asp Gly His Pro Glu Met Gly Phe His His Ala Thr 
        35                  40                  45              


Gln Ala Cys Leu Glu Leu Leu Gly Ser Ser Asp Leu Pro Ala Ser Ala 
    50                  55                  60                  


Ser Gln Ser Ala Gly Ile Thr Gly Val Asn His Arg Ala Gln Pro Gly 
65                  70                  75                  80  


Leu Asn Val Ser Val Asp Lys Phe Thr Ala Met Ser Ser His Phe Thr 
                85                  90                  95      


Gln Asp Leu Leu Pro Glu Gln Gly Ile Gln Asp Ala Phe Pro Lys Arg 
            100                 105                 110         


Ile Leu Arg Gly Tyr Gly Asn Cys Gly Leu Asp Asn Leu Tyr Leu Arg 
        115                 120                 125             


Lys Asp Trp Glu Ser Leu Asp Glu Cys Lys Leu Gln Lys Asp Tyr Asn 
    130                 135                 140                 


Gly Leu Asn Gln Cys Ser Ser Thr Thr His Ser Lys Ile Phe Gln Tyr 
145                 150                 155                 160 


Asn Lys Tyr Val Lys Ile Phe Asp Asn Phe Ser Asn Leu His Arg Arg 
                165                 170                 175     


Asn Ile Ser Asn Thr Gly Glu Lys Pro Phe Lys Cys Gln Glu Cys Gly 
            180                 185                 190         


Lys Ser Phe Gln Met Leu Ser Phe Leu Thr Glu His Gln Lys Ile His 
        195                 200                 205             


Thr Gly Lys Lys Phe Gln Lys Cys Gly Glu Cys Gly Lys Thr Phe Ile 
    210                 215                 220                 


Gln Cys Ser His Phe Thr Glu Pro Glu Asn Ile Asp Thr Gly Glu Lys 
225                 230                 235                 240 


Pro Tyr Lys Cys Gln Glu Cys Asn Asn Val Ile Lys Thr Cys Ser Val 
                245                 250                 255     


Leu Thr Lys Asn Arg Ile Tyr Ala Gly Gly Glu His Tyr Arg Cys Glu 
            260                 265                 270         


Glu Phe Gly Lys Val Phe Asn Gln Cys Ser His Leu Thr Glu His Glu 
        275                 280                 285             


His Gly Thr Glu Glu Lys Pro Cys Lys Tyr Glu Glu Cys Ser Ser Val 
    290                 295                 300                 


Phe Ile Ser Cys Ser Ser Leu Ser Asn Gln Gln Met Ile Leu Ala Gly 
305                 310                 315                 320 


Glu Lys Leu Ser Lys Cys Glu Thr Trp Tyr Lys Gly Phe Asn His Ser 
                325                 330                 335     


Pro Asn Pro Ser Lys His Gln Arg Asn Glu Ile Gly Gly Lys Pro Phe 
            340                 345                 350         


Lys Cys Glu Glu Cys Asp Ser Ile Phe Lys Trp Phe Ser Asp Leu Thr 
        355                 360                 365             


Lys His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu 
    370                 375                 380                 


Cys Gly Lys Ala Tyr Thr Gln Ser Ser His Leu Ser Glu His Arg Arg 
385                 390                 395                 400 


Ile His Thr Gly Glu Lys Pro Tyr Gln Cys Glu Glu Cys Gly Lys Val 
                405                 410                 415     


Phe Arg Thr Cys Ser Ser Leu Ser Asn His Lys Arg Thr His Ser Glu 
            420                 425                 430         


Glu Lys Pro Tyr Thr Cys Glu Glu Cys Gly Asn Ile Phe Lys Gln Leu 
        435                 440                 445             


Ser Asp Leu Thr Lys His Lys Lys Thr His Thr Gly Glu Lys Pro Tyr 
    450                 455                 460                 


Lys Cys Asp Glu Cys Gly Lys Asn Phe Thr Gln Ser Ser Asn Leu Ile 
465                 470                 475                 480 


Val His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu 
                485                 490                 495     


Cys Gly Arg Val Phe Met Trp Phe Ser Asp Ile Thr Lys His Lys Lys 
            500                 505                 510         


Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly Lys Asn 
        515                 520                 525             


Phe Thr Gln Ser Ser Asn Leu Ile Val His Lys Arg Ile His Thr Gly 
    530                 535                 540                 


Glu Lys Pro Tyr Lys Cys Glu Lys Cys Gly Lys Ala Phe Thr Gln Phe 
545                 550                 555                 560 


Ser His Leu Thr Val His Glu Ser Ile His Thr 
                565                 570     

<210>  2602
<211>  3431
<212>  DNA
<213>  Homo sapiens

<400>  2602
gtgtcccctg ctagccgtag gtcgtgtgac ccgcaggcac cgggagatcc agaagtgaaa     60

cgccaggctc tctggaggcc aggagatgtt tcagtattgt ccagggataa cacaggatgc    120

ccaccatggc catgtctgct ggagcatcta gtgaatttca ggccctgggt tatttctcag    180

aggacagcct gaggtatgaa gtgtggcctc tccagggagc agctggatgc cctgggctga    240

gagaaatctc ctggtctact cttcctctaa agaggtgtga tttgtccaga gaatctttcc    300

taagaggaaa tcccagagaa gcaggagaaa gagaaagaaa tggctggtgc tcagactctg    360

ttgacgttca gggatgtggc catagaattc tccctggagg agtggaaatg cctggacctc    420

gctcagcaga atttgtacag ggatgtgatg ttggagaact acagaaactt gttctccgtt    480

ggtctcactg tctgtaagcc aggcctgatc acctgcctgg agcaacgaaa agagccctgg    540

aatgtgaaga gacaggaggc agcagacgga catccagaga tgggatttca ccatgctact    600

caggcttgtc ttgaactcct gggctcaagc gatctgcctg cctcagcctc ccaaagtgct    660

gggattacag gtgtgaacca ccgtgcccag ccaggcctca atgtttctgt ggacaaattc    720

actgcactgt gctcacctgg ggtgctgcaa actgtgaaat ggtttttaga gttcagatgc    780

atcttctcac tagctatgtc ttctcatttt acccaagacc ttctgccaga gcagggcata    840

caagatgcat tcccaaaaag aatactgaga ggatatggaa attgtggcct tgataattta    900

tatttaagga aagactggga aagtttagat gagtgtaagt tgcaaaaaga ttataatgga    960

cttaaccaat gttcatcaac tacccatagc aaaatctttc aatataataa atatgttaaa   1020

atctttgata acttttcaaa tttacataga cgtaatataa gtaatactgg agagaaacct   1080

ttcaaatgtc aagaatgtgg caaatccttt caaatgctct cattcctaac tgaacatcag   1140

aaaattcaca ctggaaaaaa attccaaaaa tgtggagaat gtggcaaaac ctttatccag   1200

tgctcacact ttactgaacc tgagaacatt gacactggag agaaacctta caagtgtcaa   1260

gaatgtaaca acgtcattaa aacttgctca gtccttacta aaaatagaat ttatgccgga   1320

ggggaacatt acagatgtga agaatttggc aaagtattta accagtgctc ccaccttact   1380

gaacatgagc atggtactga ggaaaaaccc tgcaaatatg aagagtgcag cagtgtcttt   1440

atctcttgct caagcctttc taatcaacag atgattcttg ctggagagaa gctctccaaa   1500

tgtgaaacat ggtacaaagg ttttaaccac agcccaaatc cttccaaaca ccagagaaat   1560

gagattggag ggaaaccttt caaatgtgag gaatgtgaca gcatcttcaa gtggttctca   1620

gaccttacta aacataagag aattcacact ggtgagaaac catacaaatg tgacgaatgt   1680

gggaaagcct atacacagtc ctcacacctc agtgaacaca ggaggattca caccggagag   1740

aaaccctacc aatgtgaaga atgtgggaag gtcttcagaa cttgctcaag cctttctaac   1800

cataagagaa ctcattctga agaaaaaccc tacacgtgtg aagaatgtgg caacatcttt   1860

aagcagttat cagacctcac taagcataag aaaacccata ctggagagaa gccctacaaa   1920

tgtgacgaat gtggaaaaaa ctttacccag tcctccaacc ttattgtaca taagagaatt   1980

catactggag agaaacccta caagtgtgaa gaatgtggca gagtcttcat gtggttctca   2040

gacattacca aacataagaa aacccatact ggagagaaac cctacaaatg tgacgaatgt   2100

ggaaaaaact ttacccagtc ctcaaacctt attgtacata agagaattca tactggagag   2160

aaaccctaca agtgtgaaaa gtgtggcaaa gccttcaccc agttctcaca cctgactgta   2220

catgaaagca ttcatacttg agaaaaaaat aaacaaatat aaaaataggc aaagccgtta   2280

gtatctgctc gcatcccact ttacatcaga gttcagactt aataaagtta tcataaatgt   2340

aattactatt gaaagacctt tcatgaaata taagtctcca gagcacacaa gagtatttct   2400

tctgaaaaaa atgttacaat tatactagat ggaagacttg catcagttgc ttaaactttc   2460

agaaaatttg tagagaaacc caacaaatct cataaatgtg gaataacatt tgttcaaaaa   2520

tgatagctta gaaaacacta gagttcatac taaaagatat tttgcaaata cactaaatgg   2580

gaaaaataag caaggacacg ttcagaaatg acactgaatc cctgtgttga gtctacagag   2640

acatctagac ttaaaataga tcatttatat ttaagtttaa aaggaggatg agactgagtt   2700

tttgtagagt tataattaca ttcaaaatat acttttttgc attgaaaaaa tgttaaattt   2760

ttgaaaagcg aatattgatg tcattctatt ctcaaatcag tagatgctgt gtcttcattt   2820

ctagtgctga tgtgaaaaca catggtcagt tgttgctgcg tcagagatat gagaaattct   2880

tttctcttag gtgtgcatca ctgatatact tgtccgtgaa aggtgaaaga cactgaaatg   2940

taagatgcgt gagtaaaatc ttggtagaga ggctctttgt ggttgtttta tatacttgta   3000

agtgatttat gagataggtg tttagaataa tactcttctg ttagggtcac cctgatcaga   3060

ccgttccctt cccctcccac aggacttaca atacggtccc ttgtgctctc tgcacagcta   3120

ccccagggca aaaaacaaac cccccttcac tgatccctcc agtaactgtg cagacagtta   3180

caggatgcgg ttaacatgtc tgttcacctc gcataacaaa gctggcaaaa aacatctcca   3240

ggatgcagac aagacacctg caccctcgac taagctcccc caccccaacc cagttctcct   3300

gcacccccaa ctcagctccc gcaccccgac ctagttctgg ccctataaaa acctgctata   3360

gtctgtaagc agggctgcct cctctaactg tggtggagca gccaagcagc tcaataaagc   3420

ttgcttgcct g                                                        3431


<210>  2603
<211>  633
<212>  PRT
<213>  Homo sapiens

<400>  2603


Met Ala Gly Ala Gln Thr Leu Leu Thr Phe Arg Asp Val Ala Ile Glu 
1               5                   10                  15      


Phe Ser Leu Glu Glu Trp Lys Cys Leu Asp Leu Ala Gln Gln Asn Leu 
            20                  25                  30          


Tyr Arg Asp Val Met Leu Glu Asn Tyr Arg Asn Leu Phe Ser Val Gly 
        35                  40                  45              


Leu Thr Val Cys Lys Pro Gly Leu Ile Thr Cys Leu Glu Gln Arg Lys 
    50                  55                  60                  


Glu Pro Trp Asn Val Lys Arg Gln Glu Ala Ala Asp Gly His Pro Glu 
65                  70                  75                  80  


Met Gly Phe His His Ala Thr Gln Ala Cys Leu Glu Leu Leu Gly Ser 
                85                  90                  95      


Ser Asp Leu Pro Ala Ser Ala Ser Gln Ser Ala Gly Ile Thr Gly Val 
            100                 105                 110         


Asn His Arg Ala Gln Pro Gly Leu Asn Val Ser Val Asp Lys Phe Thr 
        115                 120                 125             


Ala Leu Cys Ser Pro Gly Val Leu Gln Thr Val Lys Trp Phe Leu Glu 
    130                 135                 140                 


Phe Arg Cys Ile Phe Ser Leu Ala Met Ser Ser His Phe Thr Gln Asp 
145                 150                 155                 160 


Leu Leu Pro Glu Gln Gly Ile Gln Asp Ala Phe Pro Lys Arg Ile Leu 
                165                 170                 175     


Arg Gly Tyr Gly Asn Cys Gly Leu Asp Asn Leu Tyr Leu Arg Lys Asp 
            180                 185                 190         


Trp Glu Ser Leu Asp Glu Cys Lys Leu Gln Lys Asp Tyr Asn Gly Leu 
        195                 200                 205             


Asn Gln Cys Ser Ser Thr Thr His Ser Lys Ile Phe Gln Tyr Asn Lys 
    210                 215                 220                 


Tyr Val Lys Ile Phe Asp Asn Phe Ser Asn Leu His Arg Arg Asn Ile 
225                 230                 235                 240 


Ser Asn Thr Gly Glu Lys Pro Phe Lys Cys Gln Glu Cys Gly Lys Ser 
                245                 250                 255     


Phe Gln Met Leu Ser Phe Leu Thr Glu His Gln Lys Ile His Thr Gly 
            260                 265                 270         


Lys Lys Phe Gln Lys Cys Gly Glu Cys Gly Lys Thr Phe Ile Gln Cys 
        275                 280                 285             


Ser His Phe Thr Glu Pro Glu Asn Ile Asp Thr Gly Glu Lys Pro Tyr 
    290                 295                 300                 


Lys Cys Gln Glu Cys Asn Asn Val Ile Lys Thr Cys Ser Val Leu Thr 
305                 310                 315                 320 


Lys Asn Arg Ile Tyr Ala Gly Gly Glu His Tyr Arg Cys Glu Glu Phe 
                325                 330                 335     


Gly Lys Val Phe Asn Gln Cys Ser His Leu Thr Glu His Glu His Gly 
            340                 345                 350         


Thr Glu Glu Lys Pro Cys Lys Tyr Glu Glu Cys Ser Ser Val Phe Ile 
        355                 360                 365             


Ser Cys Ser Ser Leu Ser Asn Gln Gln Met Ile Leu Ala Gly Glu Lys 
    370                 375                 380                 


Leu Ser Lys Cys Glu Thr Trp Tyr Lys Gly Phe Asn His Ser Pro Asn 
385                 390                 395                 400 


Pro Ser Lys His Gln Arg Asn Glu Ile Gly Gly Lys Pro Phe Lys Cys 
                405                 410                 415     


Glu Glu Cys Asp Ser Ile Phe Lys Trp Phe Ser Asp Leu Thr Lys His 
            420                 425                 430         


Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly 
        435                 440                 445             


Lys Ala Tyr Thr Gln Ser Ser His Leu Ser Glu His Arg Arg Ile His 
    450                 455                 460                 


Thr Gly Glu Lys Pro Tyr Gln Cys Glu Glu Cys Gly Lys Val Phe Arg 
465                 470                 475                 480 


Thr Cys Ser Ser Leu Ser Asn His Lys Arg Thr His Ser Glu Glu Lys 
                485                 490                 495     


Pro Tyr Thr Cys Glu Glu Cys Gly Asn Ile Phe Lys Gln Leu Ser Asp 
            500                 505                 510         


Leu Thr Lys His Lys Lys Thr His Thr Gly Glu Lys Pro Tyr Lys Cys 
        515                 520                 525             


Asp Glu Cys Gly Lys Asn Phe Thr Gln Ser Ser Asn Leu Ile Val His 
    530                 535                 540                 


Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly 
545                 550                 555                 560 


Arg Val Phe Met Trp Phe Ser Asp Ile Thr Lys His Lys Lys Thr His 
                565                 570                 575     


Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly Lys Asn Phe Thr 
            580                 585                 590         


Gln Ser Ser Asn Leu Ile Val His Lys Arg Ile His Thr Gly Glu Lys 
        595                 600                 605             


Pro Tyr Lys Cys Glu Lys Cys Gly Lys Ala Phe Thr Gln Phe Ser His 
    610                 615                 620                 


Leu Thr Val His Glu Ser Ile His Thr 
625                 630             

<210>  2604
<211>  3465
<212>  DNA
<213>  Homo sapiens

<400>  2604
ctgtccccgc ggctctgtgt cccctgctag ccgtaggtcg tgtgacccgc aggcaccggg     60

agatccagaa gtgaaacgcc aggctctctg gaggccagga gatggcacag acaccttacc    120

agaatgtctt tggtttgagg ttccactttg gaaacttgac agggtgattt gctctcagcc    180

accctctgga ctttttcctc agtttcagta ttgtccaggg ataacacagg atgcccacca    240

tggccatgtc tgctggagca tctagtgaat ttcaggccct gggttatttc tcagaggaca    300

gcctgaggta tgaagtgtgg cctctccagg gagcagctgg atgccctggg ctgagagaaa    360

tctcctggtc tactcttcct ctaaagagac tctgttgacg ttcagggatg tggccataga    420

attctccctg gaggagtgga aatgcctgga cctcgctcag cagaatttgt acagggatgt    480

gatgttggag aactacagaa acttgttctc cgttggtctc actgtctgta agccaggcct    540

gatcacctgc ctggagcaac gaaaagagcc ctggaatgtg aagagacagg aggcagcaga    600

cggacatcca gagatgggat ttcaccatgc tactcaggct tgtcttgaac tcctgggctc    660

aagcgatctg cctgcctcag cctcccaaag tgctgggatt acaggtgtga accaccgtgc    720

ccagccaggc ctcaatgttt ctgtggacaa attcactgca ctgtgctcac ctggggtgct    780

gcaaactgtg aaatggtttt tagagttcag atgcatcttc tcactagcta tgtcttctca    840

ttttacccaa gaccttctgc cagagcaggg catacaagat gcattcccaa aaagaatact    900

gagaggatat ggaaattgtg gccttgataa tttatattta aggaaagact gggaaagttt    960

agatgagtgt aagttgcaaa aagattataa tggacttaac caatgttcat caactaccca   1020

tagcaaaatc tttcaatata ataaatatgt taaaatcttt gataactttt caaatttaca   1080

tagacgtaat ataagtaata ctggagagaa acctttcaaa tgtcaagaat gtggcaaatc   1140

ctttcaaatg ctctcattcc taactgaaca tcagaaaatt cacactggaa aaaaattcca   1200

aaaatgtgga gaatgtggca aaacctttat ccagtgctca cactttactg aacctgagaa   1260

cattgacact ggagagaaac cttacaagtg tcaagaatgt aacaacgtca ttaaaacttg   1320

ctcagtcctt actaaaaata gaatttatgc cggaggggaa cattacagat gtgaagaatt   1380

tggcaaagta tttaaccagt gctcccacct tactgaacat gagcatggta ctgaggaaaa   1440

accctgcaaa tatgaagagt gcagcagtgt ctttatctct tgctcaagcc tttctaatca   1500

acagatgatt cttgctggag agaagctctc caaatgtgaa acatggtaca aaggttttaa   1560

ccacagccca aatccttcca aacaccagag aaatgagatt ggagggaaac ctttcaaatg   1620

tgaggaatgt gacagcatct tcaagtggtt ctcagacctt actaaacata agagaattca   1680

cactggtgag aaaccataca aatgtgacga atgtgggaaa gcctatacac agtcctcaca   1740

cctcagtgaa cacaggagga ttcacaccgg agagaaaccc taccaatgtg aagaatgtgg   1800

gaaggtcttc agaacttgct caagcctttc taaccataag agaactcatt ctgaagaaaa   1860

accctacacg tgtgaagaat gtggcaacat ctttaagcag ttatcagacc tcactaagca   1920

taagaaaacc catactggag agaagcccta caaatgtgac gaatgtggaa aaaactttac   1980

ccagtcctcc aaccttattg tacataagag aattcatact ggagagaaac cctacaagtg   2040

tgaagaatgt ggcagagtct tcatgtggtt ctcagacatt accaaacata agaaaaccca   2100

tactggagag aaaccctaca aatgtgacga atgtggaaaa aactttaccc agtcctcaaa   2160

ccttattgta cataagagaa ttcatactgg agagaaaccc tacaagtgtg aaaagtgtgg   2220

caaagccttc acccagttct cacacctgac tgtacatgaa agcattcata cttgagaaaa   2280

aaataaacaa atataaaaat aggcaaagcc gttagtatct gctcgcatcc cactttacat   2340

cagagttcag acttaataaa gttatcataa atgtaattac tattgaaaga cctttcatga   2400

aatataagtc tccagagcac acaagagtat ttcttctgaa aaaaatgtta caattatact   2460

agatggaaga cttgcatcag ttgcttaaac tttcagaaaa tttgtagaga aacccaacaa   2520

atctcataaa tgtggaataa catttgttca aaaatgatag cttagaaaac actagagttc   2580

atactaaaag atattttgca aatacactaa atgggaaaaa taagcaagga cacgttcaga   2640

aatgacactg aatccctgtg ttgagtctac agagacatct agacttaaaa tagatcattt   2700

atatttaagt ttaaaaggag gatgagactg agtttttgta gagttataat tacattcaaa   2760

atatactttt ttgcattgaa aaaatgttaa atttttgaaa agcgaatatt gatgtcattc   2820

tattctcaaa tcagtagatg ctgtgtcttc atttctagtg ctgatgtgaa aacacatggt   2880

cagttgttgc tgcgtcagag atatgagaaa ttcttttctc ttaggtgtgc atcactgata   2940

tacttgtccg tgaaaggtga aagacactga aatgtaagat gcgtgagtaa aatcttggta   3000

gagaggctct ttgtggttgt tttatatact tgtaagtgat ttatgagata ggtgtttaga   3060

ataatactct tctgttaggg tcaccctgat cagaccgttc ccttcccctc ccacaggact   3120

tacaatacgg tcccttgtgc tctctgcaca gctaccccag ggcaaaaaac aaacccccct   3180

tcactgatcc ctccagtaac tgtgcagaca gttacaggat gcggttaaca tgtctgttca   3240

cctcgcataa caaagctggc aaaaaacatc tccaggatgc agacaagaca cctgcaccct   3300

cgactaagct cccccacccc aacccagttc tcctgcaccc ccaactcagc tcccgcaccc   3360

cgacctagtt ctggccctat aaaaacctgc tatagtctgt aagcagggct gcctcctcta   3420

actgtggtgg agcagccaag cagctcaata aagcttgctt gcctg                   3465


<210>  2605
<211>  644
<212>  PRT
<213>  Homo sapiens

<400>  2605


Met Pro Trp Ala Glu Arg Asn Leu Leu Val Tyr Ser Ser Ser Lys Glu 
1               5                   10                  15      


Thr Leu Leu Thr Phe Arg Asp Val Ala Ile Glu Phe Ser Leu Glu Glu 
            20                  25                  30          


Trp Lys Cys Leu Asp Leu Ala Gln Gln Asn Leu Tyr Arg Asp Val Met 
        35                  40                  45              


Leu Glu Asn Tyr Arg Asn Leu Phe Ser Val Gly Leu Thr Val Cys Lys 
    50                  55                  60                  


Pro Gly Leu Ile Thr Cys Leu Glu Gln Arg Lys Glu Pro Trp Asn Val 
65                  70                  75                  80  


Lys Arg Gln Glu Ala Ala Asp Gly His Pro Glu Met Gly Phe His His 
                85                  90                  95      


Ala Thr Gln Ala Cys Leu Glu Leu Leu Gly Ser Ser Asp Leu Pro Ala 
            100                 105                 110         


Ser Ala Ser Gln Ser Ala Gly Ile Thr Gly Val Asn His Arg Ala Gln 
        115                 120                 125             


Pro Gly Leu Asn Val Ser Val Asp Lys Phe Thr Ala Leu Cys Ser Pro 
    130                 135                 140                 


Gly Val Leu Gln Thr Val Lys Trp Phe Leu Glu Phe Arg Cys Ile Phe 
145                 150                 155                 160 


Ser Leu Ala Met Ser Ser His Phe Thr Gln Asp Leu Leu Pro Glu Gln 
                165                 170                 175     


Gly Ile Gln Asp Ala Phe Pro Lys Arg Ile Leu Arg Gly Tyr Gly Asn 
            180                 185                 190         


Cys Gly Leu Asp Asn Leu Tyr Leu Arg Lys Asp Trp Glu Ser Leu Asp 
        195                 200                 205             


Glu Cys Lys Leu Gln Lys Asp Tyr Asn Gly Leu Asn Gln Cys Ser Ser 
    210                 215                 220                 


Thr Thr His Ser Lys Ile Phe Gln Tyr Asn Lys Tyr Val Lys Ile Phe 
225                 230                 235                 240 


Asp Asn Phe Ser Asn Leu His Arg Arg Asn Ile Ser Asn Thr Gly Glu 
                245                 250                 255     


Lys Pro Phe Lys Cys Gln Glu Cys Gly Lys Ser Phe Gln Met Leu Ser 
            260                 265                 270         


Phe Leu Thr Glu His Gln Lys Ile His Thr Gly Lys Lys Phe Gln Lys 
        275                 280                 285             


Cys Gly Glu Cys Gly Lys Thr Phe Ile Gln Cys Ser His Phe Thr Glu 
    290                 295                 300                 


Pro Glu Asn Ile Asp Thr Gly Glu Lys Pro Tyr Lys Cys Gln Glu Cys 
305                 310                 315                 320 


Asn Asn Val Ile Lys Thr Cys Ser Val Leu Thr Lys Asn Arg Ile Tyr 
                325                 330                 335     


Ala Gly Gly Glu His Tyr Arg Cys Glu Glu Phe Gly Lys Val Phe Asn 
            340                 345                 350         


Gln Cys Ser His Leu Thr Glu His Glu His Gly Thr Glu Glu Lys Pro 
        355                 360                 365             


Cys Lys Tyr Glu Glu Cys Ser Ser Val Phe Ile Ser Cys Ser Ser Leu 
    370                 375                 380                 


Ser Asn Gln Gln Met Ile Leu Ala Gly Glu Lys Leu Ser Lys Cys Glu 
385                 390                 395                 400 


Thr Trp Tyr Lys Gly Phe Asn His Ser Pro Asn Pro Ser Lys His Gln 
                405                 410                 415     


Arg Asn Glu Ile Gly Gly Lys Pro Phe Lys Cys Glu Glu Cys Asp Ser 
            420                 425                 430         


Ile Phe Lys Trp Phe Ser Asp Leu Thr Lys His Lys Arg Ile His Thr 
        435                 440                 445             


Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly Lys Ala Tyr Thr Gln 
    450                 455                 460                 


Ser Ser His Leu Ser Glu His Arg Arg Ile His Thr Gly Glu Lys Pro 
465                 470                 475                 480 


Tyr Gln Cys Glu Glu Cys Gly Lys Val Phe Arg Thr Cys Ser Ser Leu 
                485                 490                 495     


Ser Asn His Lys Arg Thr His Ser Glu Glu Lys Pro Tyr Thr Cys Glu 
            500                 505                 510         


Glu Cys Gly Asn Ile Phe Lys Gln Leu Ser Asp Leu Thr Lys His Lys 
        515                 520                 525             


Lys Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly Lys 
    530                 535                 540                 


Asn Phe Thr Gln Ser Ser Asn Leu Ile Val His Lys Arg Ile His Thr 
545                 550                 555                 560 


Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Arg Val Phe Met Trp 
                565                 570                 575     


Phe Ser Asp Ile Thr Lys His Lys Lys Thr His Thr Gly Glu Lys Pro 
            580                 585                 590         


Tyr Lys Cys Asp Glu Cys Gly Lys Asn Phe Thr Gln Ser Ser Asn Leu 
        595                 600                 605             


Ile Val His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu 
    610                 615                 620                 


Lys Cys Gly Lys Ala Phe Thr Gln Phe Ser His Leu Thr Val His Glu 
625                 630                 635                 640 


Ser Ile His Thr 
                

<210>  2606
<211>  3440
<212>  DNA
<213>  Homo sapiens

<400>  2606
agagctccac ttcctgtccc cgcggctctg tgtcccctgc tagccgtagg tcgtgtgacc     60

cgcaggcacc gggagatcca gaagtgaaac gccaggctct ctggaggcca ggagatgcca    120

ttaggaaaac agagaaggca gccatggtcc ccgcaagcca gaaacttttc catttccagt    180

aactggataa atcattgaat tcagcgtctt ggggtcagca tgaagaaggg agtggtcaaa    240

gggacttctg cttcatttgg gccattttcc tgatgtggtt gttgtgtgat ttgtccagag    300

aatctttcct aagaggaaat cccagagaag caggagaaag agaaagaaat ggctggtgct    360

cagactctgt tgacgttcag ggatgtggcc atagaattct ccctggagga gtggaaatgc    420

ctggacctcg ctcagcagaa tttgtacagg gatgtgatgt tggagaacta cagaaacttg    480

ttctccgttg gtctcactgt ctgtaagcca ggcctgatca cctgcctgga gcaacgaaaa    540

gagccctgga atgtgaagag acaggaggca gcagacggac atccagagat gggatttcac    600

catgctactc aggcttgtct tgaactcctg ggctcaagcg atctgcctgc ctcagcctcc    660

caaagtgctg ggattacagg tgtgaaccac cgtgcccagc caggcctcaa tgtttctgtg    720

gacaaattca ctgcactgtg ctcacctggg gtgctgcaaa ctgtgaaatg gtttttagag    780

ttcagatgca tcttctcact agctatgtct tctcatttta cccaagacct tctgccagag    840

cagggcatac aagatgcatt cccaaaaaga atactgagag gatatggaaa ttgtggcctt    900

gataatttat atttaaggaa agactgggaa agtttagatg agtgtaagtt gcaaaaagat    960

tataatggac ttaaccaatg ttcatcaact acccatagca aaatctttca atataataaa   1020

tatgttaaaa tctttgataa cttttcaaat ttacatagac gtaatataag taatactgga   1080

gagaaacctt tcaaatgtca agaatgtggc aaatcctttc aaatgctctc attcctaact   1140

gaacatcaga aaattcacac tggaaaaaaa ttccaaaaat gtggagaatg tggcaaaacc   1200

tttatccagt gctcacactt tactgaacct gagaacattg acactggaga gaaaccttac   1260

aagtgtcaag aatgtaacaa cgtcattaaa acttgctcag tccttactaa aaatagaatt   1320

tatgccggag gggaacatta cagatgtgaa gaatttggca aagtatttaa ccagtgctcc   1380

caccttactg aacatgagca tggtactgag gaaaaaccct gcaaatatga agagtgcagc   1440

agtgtcttta tctcttgctc aagcctttct aatcaacaga tgattcttgc tggagagaag   1500

ctctccaaat gtgaaacatg gtacaaaggt tttaaccaca gcccaaatcc ttccaaacac   1560

cagagaaatg agattggagg gaaacctttc aaatgtgagg aatgtgacag catcttcaag   1620

tggttctcag accttactaa acataagaga attcacactg gtgagaaacc atacaaatgt   1680

gacgaatgtg ggaaagccta tacacagtcc tcacacctca gtgaacacag gaggattcac   1740

accggagaga aaccctacca atgtgaagaa tgtgggaagg tcttcagaac ttgctcaagc   1800

ctttctaacc ataagagaac tcattctgaa gaaaaaccct acacgtgtga agaatgtggc   1860

aacatcttta agcagttatc agacctcact aagcataaga aaacccatac tggagagaag   1920

ccctacaaat gtgacgaatg tggaaaaaac tttacccagt cctccaacct tattgtacat   1980

aagagaattc atactggaga gaaaccctac aagtgtgaag aatgtggcag agtcttcatg   2040

tggttctcag acattaccaa acataagaaa acccatactg gagagaaacc ctacaaatgt   2100

gacgaatgtg gaaaaaactt tacccagtcc tcaaacctta ttgtacataa gagaattcat   2160

actggagaga aaccctacaa gtgtgaaaag tgtggcaaag ccttcaccca gttctcacac   2220

ctgactgtac atgaaagcat tcatacttga gaaaaaaata aacaaatata aaaataggca   2280

aagccgttag tatctgctcg catcccactt tacatcagag ttcagactta ataaagttat   2340

cataaatgta attactattg aaagaccttt catgaaatat aagtctccag agcacacaag   2400

agtatttctt ctgaaaaaaa tgttacaatt atactagatg gaagacttgc atcagttgct   2460

taaactttca gaaaatttgt agagaaaccc aacaaatctc ataaatgtgg aataacattt   2520

gttcaaaaat gatagcttag aaaacactag agttcatact aaaagatatt ttgcaaatac   2580

actaaatggg aaaaataagc aaggacacgt tcagaaatga cactgaatcc ctgtgttgag   2640

tctacagaga catctagact taaaatagat catttatatt taagtttaaa aggaggatga   2700

gactgagttt ttgtagagtt ataattacat tcaaaatata cttttttgca ttgaaaaaat   2760

gttaaatttt tgaaaagcga atattgatgt cattctattc tcaaatcagt agatgctgtg   2820

tcttcatttc tagtgctgat gtgaaaacac atggtcagtt gttgctgcgt cagagatatg   2880

agaaattctt ttctcttagg tgtgcatcac tgatatactt gtccgtgaaa ggtgaaagac   2940

actgaaatgt aagatgcgtg agtaaaatct tggtagagag gctctttgtg gttgttttat   3000

atacttgtaa gtgatttatg agataggtgt ttagaataat actcttctgt tagggtcacc   3060

ctgatcagac cgttcccttc ccctcccaca ggacttacaa tacggtccct tgtgctctct   3120

gcacagctac cccagggcaa aaaacaaacc ccccttcact gatccctcca gtaactgtgc   3180

agacagttac aggatgcggt taacatgtct gttcacctcg cataacaaag ctggcaaaaa   3240

acatctccag gatgcagaca agacacctgc accctcgact aagctccccc accccaaccc   3300

agttctcctg cacccccaac tcagctcccg caccccgacc tagttctggc cctataaaaa   3360

cctgctatag tctgtaagca gggctgcctc ctctaactgt ggtggagcag ccaagcagct   3420

caataaagct tgcttgcctg                                               3440


<210>  2607
<211>  633
<212>  PRT
<213>  Homo sapiens

<400>  2607


Met Ala Gly Ala Gln Thr Leu Leu Thr Phe Arg Asp Val Ala Ile Glu 
1               5                   10                  15      


Phe Ser Leu Glu Glu Trp Lys Cys Leu Asp Leu Ala Gln Gln Asn Leu 
            20                  25                  30          


Tyr Arg Asp Val Met Leu Glu Asn Tyr Arg Asn Leu Phe Ser Val Gly 
        35                  40                  45              


Leu Thr Val Cys Lys Pro Gly Leu Ile Thr Cys Leu Glu Gln Arg Lys 
    50                  55                  60                  


Glu Pro Trp Asn Val Lys Arg Gln Glu Ala Ala Asp Gly His Pro Glu 
65                  70                  75                  80  


Met Gly Phe His His Ala Thr Gln Ala Cys Leu Glu Leu Leu Gly Ser 
                85                  90                  95      


Ser Asp Leu Pro Ala Ser Ala Ser Gln Ser Ala Gly Ile Thr Gly Val 
            100                 105                 110         


Asn His Arg Ala Gln Pro Gly Leu Asn Val Ser Val Asp Lys Phe Thr 
        115                 120                 125             


Ala Leu Cys Ser Pro Gly Val Leu Gln Thr Val Lys Trp Phe Leu Glu 
    130                 135                 140                 


Phe Arg Cys Ile Phe Ser Leu Ala Met Ser Ser His Phe Thr Gln Asp 
145                 150                 155                 160 


Leu Leu Pro Glu Gln Gly Ile Gln Asp Ala Phe Pro Lys Arg Ile Leu 
                165                 170                 175     


Arg Gly Tyr Gly Asn Cys Gly Leu Asp Asn Leu Tyr Leu Arg Lys Asp 
            180                 185                 190         


Trp Glu Ser Leu Asp Glu Cys Lys Leu Gln Lys Asp Tyr Asn Gly Leu 
        195                 200                 205             


Asn Gln Cys Ser Ser Thr Thr His Ser Lys Ile Phe Gln Tyr Asn Lys 
    210                 215                 220                 


Tyr Val Lys Ile Phe Asp Asn Phe Ser Asn Leu His Arg Arg Asn Ile 
225                 230                 235                 240 


Ser Asn Thr Gly Glu Lys Pro Phe Lys Cys Gln Glu Cys Gly Lys Ser 
                245                 250                 255     


Phe Gln Met Leu Ser Phe Leu Thr Glu His Gln Lys Ile His Thr Gly 
            260                 265                 270         


Lys Lys Phe Gln Lys Cys Gly Glu Cys Gly Lys Thr Phe Ile Gln Cys 
        275                 280                 285             


Ser His Phe Thr Glu Pro Glu Asn Ile Asp Thr Gly Glu Lys Pro Tyr 
    290                 295                 300                 


Lys Cys Gln Glu Cys Asn Asn Val Ile Lys Thr Cys Ser Val Leu Thr 
305                 310                 315                 320 


Lys Asn Arg Ile Tyr Ala Gly Gly Glu His Tyr Arg Cys Glu Glu Phe 
                325                 330                 335     


Gly Lys Val Phe Asn Gln Cys Ser His Leu Thr Glu His Glu His Gly 
            340                 345                 350         


Thr Glu Glu Lys Pro Cys Lys Tyr Glu Glu Cys Ser Ser Val Phe Ile 
        355                 360                 365             


Ser Cys Ser Ser Leu Ser Asn Gln Gln Met Ile Leu Ala Gly Glu Lys 
    370                 375                 380                 


Leu Ser Lys Cys Glu Thr Trp Tyr Lys Gly Phe Asn His Ser Pro Asn 
385                 390                 395                 400 


Pro Ser Lys His Gln Arg Asn Glu Ile Gly Gly Lys Pro Phe Lys Cys 
                405                 410                 415     


Glu Glu Cys Asp Ser Ile Phe Lys Trp Phe Ser Asp Leu Thr Lys His 
            420                 425                 430         


Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly 
        435                 440                 445             


Lys Ala Tyr Thr Gln Ser Ser His Leu Ser Glu His Arg Arg Ile His 
    450                 455                 460                 


Thr Gly Glu Lys Pro Tyr Gln Cys Glu Glu Cys Gly Lys Val Phe Arg 
465                 470                 475                 480 


Thr Cys Ser Ser Leu Ser Asn His Lys Arg Thr His Ser Glu Glu Lys 
                485                 490                 495     


Pro Tyr Thr Cys Glu Glu Cys Gly Asn Ile Phe Lys Gln Leu Ser Asp 
            500                 505                 510         


Leu Thr Lys His Lys Lys Thr His Thr Gly Glu Lys Pro Tyr Lys Cys 
        515                 520                 525             


Asp Glu Cys Gly Lys Asn Phe Thr Gln Ser Ser Asn Leu Ile Val His 
    530                 535                 540                 


Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly 
545                 550                 555                 560 


Arg Val Phe Met Trp Phe Ser Asp Ile Thr Lys His Lys Lys Thr His 
                565                 570                 575     


Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly Lys Asn Phe Thr 
            580                 585                 590         


Gln Ser Ser Asn Leu Ile Val His Lys Arg Ile His Thr Gly Glu Lys 
        595                 600                 605             


Pro Tyr Lys Cys Glu Lys Cys Gly Lys Ala Phe Thr Gln Phe Ser His 
    610                 615                 620                 


Leu Thr Val His Glu Ser Ile His Thr 
625                 630             

<210>  2608
<211>  3203
<212>  DNA
<213>  Homo sapiens

<400>  2608
gtcccgacag agctccactt cctgtccccg cggctctgtg tcccctgcta gccgtaggtc     60

gtgtgacccg caggcaccgg gagatccaga agtgaaacgc caggctctct ggaggccagg    120

agatgactct gttgacgttc agggatgtgg ccatagaatt ctccctggag gagtggaaat    180

gcctggacct cgctcagcag aatttgtaca gggatgtgat gttggagaac tacagaaact    240

tgttctccgt tggtctcact gtctgtaagc caggcctgat cacctgcctg gagcaacgaa    300

aagagccctg gaatgtgaag agacaggagg cagcagacgg acatccaggt attttctttg    360

tggttaccat ggaaattata taaaacatct taaagttaca acaaggtatt ttacactgag    420

atgggatttc accatgctac tcaggcttgt cttgaactcc tgggctcaag cgatctgcct    480

gcctcagcct cccaaagtgc tgggattaca ggtgtgaacc accgtgccca gccaggcctc    540

aatgtttctg tggacaaatt cactgctatg tcttctcatt ttacccaaga ccttctgcca    600

gagcagggca tacaagatgc attcccaaaa agaatactga gaggatatgg aaattgtggc    660

cttgataatt tatatttaag gaaagactgg gaaagtttag atgagtgtaa gttgcaaaaa    720

gattataatg gacttaacca atgttcatca actacccata gcaaaatctt tcaatataat    780

aaatatgtta aaatctttga taacttttca aatttacata gacgtaatat aagtaatact    840

ggagagaaac ctttcaaatg tcaagaatgt ggcaaatcct ttcaaatgct ctcattccta    900

actgaacatc agaaaattca cactggaaaa aaattccaaa aatgtggaga atgtggcaaa    960

acctttatcc agtgctcaca ctttactgaa cctgagaaca ttgacactgg agagaaacct   1020

tacaagtgtc aagaatgtaa caacgtcatt aaaacttgct cagtccttac taaaaataga   1080

atttatgccg gaggggaaca ttacagatgt gaagaatttg gcaaagtatt taaccagtgc   1140

tcccacctta ctgaacatga gcatggtact gaggaaaaac cctgcaaata tgaagagtgc   1200

agcagtgtct ttatctcttg ctcaagcctt tctaatcaac agatgattct tgctggagag   1260

aagctctcca aatgtgaaac atggtacaaa ggttttaacc acagcccaaa tccttccaaa   1320

caccagagaa atgagattgg agggaaacct ttcaaatgtg aggaatgtga cagcatcttc   1380

aagtggttct cagaccttac taaacataag agaattcaca ctggtgagaa accatacaaa   1440

tgtgacgaat gtgggaaagc ctatacacag tcctcacacc tcagtgaaca caggaggatt   1500

cacaccggag agaaacccta ccaatgtgaa gaatgtggga aggtcttcag aacttgctca   1560

agcctttcta accataagag aactcattct gaagaaaaac cctacacgtg tgaagaatgt   1620

ggcaacatct ttaagcagtt atcagacctc actaagcata agaaaaccca tactggagag   1680

aagccctaca aatgtgacga atgtggaaaa aactttaccc agtcctccaa ccttattgta   1740

cataagagaa ttcatactgg agagaaaccc tacaagtgtg aagaatgtgg cagagtcttc   1800

atgtggttct cagacattac caaacataag aaaacccata ctggagagaa accctacaaa   1860

tgtgacgaat gtggaaaaaa ctttacccag tcctcaaacc ttattgtaca taagagaatt   1920

catactggag agaaacccta caagtgtgaa aagtgtggca aagccttcac ccagttctca   1980

cacctgactg tacatgaaag cattcatact tgagaaaaaa ataaacaaat ataaaaatag   2040

gcaaagccgt tagtatctgc tcgcatccca ctttacatca gagttcagac ttaataaagt   2100

tatcataaat gtaattacta ttgaaagacc tttcatgaaa tataagtctc cagagcacac   2160

aagagtattt cttctgaaaa aaatgttaca attatactag atggaagact tgcatcagtt   2220

gcttaaactt tcagaaaatt tgtagagaaa cccaacaaat ctcataaatg tggaataaca   2280

tttgttcaaa aatgatagct tagaaaacac tagagttcat actaaaagat attttgcaaa   2340

tacactaaat gggaaaaata agcaaggaca cgttcagaaa tgacactgaa tccctgtgtt   2400

gagtctacag agacatctag acttaaaata gatcatttat atttaagttt aaaaggagga   2460

tgagactgag tttttgtaga gttataatta cattcaaaat atactttttt gcattgaaaa   2520

aatgttaaat ttttgaaaag cgaatattga tgtcattcta ttctcaaatc agtagatgct   2580

gtgtcttcat ttctagtgct gatgtgaaaa cacatggtca gttgttgctg cgtcagagat   2640

atgagaaatt cttttctctt aggtgtgcat cactgatata cttgtccgtg aaaggtgaaa   2700

gacactgaaa tgtaagatgc gtgagtaaaa tcttggtaga gaggctcttt gtggttgttt   2760

tatatacttg taagtgattt atgagatagg tgtttagaat aatactcttc tgttagggtc   2820

accctgatca gaccgttccc ttcccctccc acaggactta caatacggtc ccttgtgctc   2880

tctgcacagc taccccaggg caaaaaacaa accccccttc actgatccct ccagtaactg   2940

tgcagacagt tacaggatgc ggttaacatg tctgttcacc tcgcataaca aagctggcaa   3000

aaaacatctc caggatgcag acaagacacc tgcaccctcg actaagctcc cccaccccaa   3060

cccagttctc ctgcaccccc aactcagctc ccgcaccccg acctagttct ggccctataa   3120

aaacctgcta tagtctgtaa gcagggctgc ctcctctaac tgtggtggag cagccaagca   3180

gctcaataaa gcttgcttgc ctg                                           3203


<210>  2609
<211>  530
<212>  PRT
<213>  Homo sapiens

<400>  2609


Met Gly Phe His His Ala Thr Gln Ala Cys Leu Glu Leu Leu Gly Ser 
1               5                   10                  15      


Ser Asp Leu Pro Ala Ser Ala Ser Gln Ser Ala Gly Ile Thr Gly Val 
            20                  25                  30          


Asn His Arg Ala Gln Pro Gly Leu Asn Val Ser Val Asp Lys Phe Thr 
        35                  40                  45              


Ala Met Ser Ser His Phe Thr Gln Asp Leu Leu Pro Glu Gln Gly Ile 
    50                  55                  60                  


Gln Asp Ala Phe Pro Lys Arg Ile Leu Arg Gly Tyr Gly Asn Cys Gly 
65                  70                  75                  80  


Leu Asp Asn Leu Tyr Leu Arg Lys Asp Trp Glu Ser Leu Asp Glu Cys 
                85                  90                  95      


Lys Leu Gln Lys Asp Tyr Asn Gly Leu Asn Gln Cys Ser Ser Thr Thr 
            100                 105                 110         


His Ser Lys Ile Phe Gln Tyr Asn Lys Tyr Val Lys Ile Phe Asp Asn 
        115                 120                 125             


Phe Ser Asn Leu His Arg Arg Asn Ile Ser Asn Thr Gly Glu Lys Pro 
    130                 135                 140                 


Phe Lys Cys Gln Glu Cys Gly Lys Ser Phe Gln Met Leu Ser Phe Leu 
145                 150                 155                 160 


Thr Glu His Gln Lys Ile His Thr Gly Lys Lys Phe Gln Lys Cys Gly 
                165                 170                 175     


Glu Cys Gly Lys Thr Phe Ile Gln Cys Ser His Phe Thr Glu Pro Glu 
            180                 185                 190         


Asn Ile Asp Thr Gly Glu Lys Pro Tyr Lys Cys Gln Glu Cys Asn Asn 
        195                 200                 205             


Val Ile Lys Thr Cys Ser Val Leu Thr Lys Asn Arg Ile Tyr Ala Gly 
    210                 215                 220                 


Gly Glu His Tyr Arg Cys Glu Glu Phe Gly Lys Val Phe Asn Gln Cys 
225                 230                 235                 240 


Ser His Leu Thr Glu His Glu His Gly Thr Glu Glu Lys Pro Cys Lys 
                245                 250                 255     


Tyr Glu Glu Cys Ser Ser Val Phe Ile Ser Cys Ser Ser Leu Ser Asn 
            260                 265                 270         


Gln Gln Met Ile Leu Ala Gly Glu Lys Leu Ser Lys Cys Glu Thr Trp 
        275                 280                 285             


Tyr Lys Gly Phe Asn His Ser Pro Asn Pro Ser Lys His Gln Arg Asn 
    290                 295                 300                 


Glu Ile Gly Gly Lys Pro Phe Lys Cys Glu Glu Cys Asp Ser Ile Phe 
305                 310                 315                 320 


Lys Trp Phe Ser Asp Leu Thr Lys His Lys Arg Ile His Thr Gly Glu 
                325                 330                 335     


Lys Pro Tyr Lys Cys Asp Glu Cys Gly Lys Ala Tyr Thr Gln Ser Ser 
            340                 345                 350         


His Leu Ser Glu His Arg Arg Ile His Thr Gly Glu Lys Pro Tyr Gln 
        355                 360                 365             


Cys Glu Glu Cys Gly Lys Val Phe Arg Thr Cys Ser Ser Leu Ser Asn 
    370                 375                 380                 


His Lys Arg Thr His Ser Glu Glu Lys Pro Tyr Thr Cys Glu Glu Cys 
385                 390                 395                 400 


Gly Asn Ile Phe Lys Gln Leu Ser Asp Leu Thr Lys His Lys Lys Thr 
                405                 410                 415     


His Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly Lys Asn Phe 
            420                 425                 430         


Thr Gln Ser Ser Asn Leu Ile Val His Lys Arg Ile His Thr Gly Glu 
        435                 440                 445             


Lys Pro Tyr Lys Cys Glu Glu Cys Gly Arg Val Phe Met Trp Phe Ser 
    450                 455                 460                 


Asp Ile Thr Lys His Lys Lys Thr His Thr Gly Glu Lys Pro Tyr Lys 
465                 470                 475                 480 


Cys Asp Glu Cys Gly Lys Asn Phe Thr Gln Ser Ser Asn Leu Ile Val 
                485                 490                 495     


His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Lys Cys 
            500                 505                 510         


Gly Lys Ala Phe Thr Gln Phe Ser His Leu Thr Val His Glu Ser Ile 
        515                 520                 525             


His Thr 
    530 

<210>  2610
<211>  2986
<212>  DNA
<213>  Homo sapiens

<400>  2610
gtcccgacag agctccactt cctgtccccg cggctctgtg tcccctgcta gccgtaggtc     60

gtgtgacccg caggcaccgg gagatccaga agtgaaacgc caggctctct ggaggccagg    120

agatgactct gttgacgttc agggatgtgg ccatagaatt ctccctggag gagtggaaat    180

gcctggacct cgctcagcag aatttgtaca gggatgtgat gttggagaac tacagaaact    240

tgttctccgt tggtctcact gtctgtaagc caggcctgat cacctgcctg gagcaacgaa    300

aagagccctg gaatgtgaag agacaggagg cagcagacgg acatccagct atgtcttctc    360

attttaccca agaccttctg ccagagcagg gcatacaaga tgcattccca aaaagaatac    420

tgagaggata tggaaattgt ggccttgata atttatattt aaggaaagac tgggaaagtt    480

tagatgagtg taagttgcaa aaagattata atggacttaa ccaatgttca tcaactaccc    540

atagcaaaat ctttcaatat aataaatatg ttaaaatctt tgataacttt tcaaatttac    600

atagacgtaa tataagtaat actggagaga aacctttcaa atgtcaagaa tgtggcaaat    660

cctttcaaat gctctcattc ctaactgaac atcagaaaat tcacactgga aaaaaattcc    720

aaaaatgtgg agaatgtggc aaaaccttta tccagtgctc acactttact gaacctgaga    780

acattgacac tggagagaaa ccttacaagt gtcaagaatg taacaacgtc attaaaactt    840

gctcagtcct tactaaaaat agaatttatg ccggagggga acattacaga tgtgaagaat    900

ttggcaaagt atttaaccag tgctcccacc ttactgaaca tgagcatggt actgaggaaa    960

aaccctgcaa atatgaagag tgcagcagtg tctttatctc ttgctcaagc ctttctaatc   1020

aacagatgat tcttgctgga gagaagctct ccaaatgtga aacatggtac aaaggtttta   1080

accacagccc aaatccttcc aaacaccaga gaaatgagat tggagggaaa cctttcaaat   1140

gtgaggaatg tgacagcatc ttcaagtggt tctcagacct tactaaacat aagagaattc   1200

acactggtga gaaaccatac aaatgtgacg aatgtgggaa agcctataca cagtcctcac   1260

acctcagtga acacaggagg attcacaccg gagagaaacc ctaccaatgt gaagaatgtg   1320

ggaaggtctt cagaacttgc tcaagccttt ctaaccataa gagaactcat tctgaagaaa   1380

aaccctacac gtgtgaagaa tgtggcaaca tctttaagca gttatcagac ctcactaagc   1440

ataagaaaac ccatactgga gagaagccct acaaatgtga cgaatgtgga aaaaacttta   1500

cccagtcctc caaccttatt gtacataaga gaattcatac tggagagaaa ccctacaagt   1560

gtgaagaatg tggcagagtc ttcatgtggt tctcagacat taccaaacat aagaaaaccc   1620

atactggaga gaaaccctac aaatgtgacg aatgtggaaa aaactttacc cagtcctcaa   1680

accttattgt acataagaga attcatactg gagagaaacc ctacaagtgt gaaaagtgtg   1740

gcaaagcctt cacccagttc tcacacctga ctgtacatga aagcattcat acttgagaaa   1800

aaaataaaca aatataaaaa taggcaaagc cgttagtatc tgctcgcatc ccactttaca   1860

tcagagttca gacttaataa agttatcata aatgtaatta ctattgaaag acctttcatg   1920

aaatataagt ctccagagca cacaagagta tttcttctga aaaaaatgtt acaattatac   1980

tagatggaag acttgcatca gttgcttaaa ctttcagaaa atttgtagag aaacccaaca   2040

aatctcataa atgtggaata acatttgttc aaaaatgata gcttagaaaa cactagagtt   2100

catactaaaa gatattttgc aaatacacta aatgggaaaa ataagcaagg acacgttcag   2160

aaatgacact gaatccctgt gttgagtcta cagagacatc tagacttaaa atagatcatt   2220

tatatttaag tttaaaagga ggatgagact gagtttttgt agagttataa ttacattcaa   2280

aatatacttt tttgcattga aaaaatgtta aatttttgaa aagcgaatat tgatgtcatt   2340

ctattctcaa atcagtagat gctgtgtctt catttctagt gctgatgtga aaacacatgg   2400

tcagttgttg ctgcgtcaga gatatgagaa attcttttct cttaggtgtg catcactgat   2460

atacttgtcc gtgaaaggtg aaagacactg aaatgtaaga tgcgtgagta aaatcttggt   2520

agagaggctc tttgtggttg ttttatatac ttgtaagtga tttatgagat aggtgtttag   2580

aataatactc ttctgttagg gtcaccctga tcagaccgtt cccttcccct cccacaggac   2640

ttacaatacg gtcccttgtg ctctctgcac agctacccca gggcaaaaaa caaacccccc   2700

ttcactgatc cctccagtaa ctgtgcagac agttacagga tgcggttaac atgtctgttc   2760

acctcgcata acaaagctgg caaaaaacat ctccaggatg cagacaagac acctgcaccc   2820

tcgactaagc tcccccaccc caacccagtt ctcctgcacc cccaactcag ctcccgcacc   2880

ccgacctagt tctggcccta taaaaacctg ctatagtctg taagcagggc tgcctcctct   2940

aactgtggtg gagcagccaa gcagctcaat aaagcttgct tgcctg                  2986


<210>  2611
<211>  557
<212>  PRT
<213>  Homo sapiens

<400>  2611


Met Thr Leu Leu Thr Phe Arg Asp Val Ala Ile Glu Phe Ser Leu Glu 
1               5                   10                  15      


Glu Trp Lys Cys Leu Asp Leu Ala Gln Gln Asn Leu Tyr Arg Asp Val 
            20                  25                  30          


Met Leu Glu Asn Tyr Arg Asn Leu Phe Ser Val Gly Leu Thr Val Cys 
        35                  40                  45              


Lys Pro Gly Leu Ile Thr Cys Leu Glu Gln Arg Lys Glu Pro Trp Asn 
    50                  55                  60                  


Val Lys Arg Gln Glu Ala Ala Asp Gly His Pro Ala Met Ser Ser His 
65                  70                  75                  80  


Phe Thr Gln Asp Leu Leu Pro Glu Gln Gly Ile Gln Asp Ala Phe Pro 
                85                  90                  95      


Lys Arg Ile Leu Arg Gly Tyr Gly Asn Cys Gly Leu Asp Asn Leu Tyr 
            100                 105                 110         


Leu Arg Lys Asp Trp Glu Ser Leu Asp Glu Cys Lys Leu Gln Lys Asp 
        115                 120                 125             


Tyr Asn Gly Leu Asn Gln Cys Ser Ser Thr Thr His Ser Lys Ile Phe 
    130                 135                 140                 


Gln Tyr Asn Lys Tyr Val Lys Ile Phe Asp Asn Phe Ser Asn Leu His 
145                 150                 155                 160 


Arg Arg Asn Ile Ser Asn Thr Gly Glu Lys Pro Phe Lys Cys Gln Glu 
                165                 170                 175     


Cys Gly Lys Ser Phe Gln Met Leu Ser Phe Leu Thr Glu His Gln Lys 
            180                 185                 190         


Ile His Thr Gly Lys Lys Phe Gln Lys Cys Gly Glu Cys Gly Lys Thr 
        195                 200                 205             


Phe Ile Gln Cys Ser His Phe Thr Glu Pro Glu Asn Ile Asp Thr Gly 
    210                 215                 220                 


Glu Lys Pro Tyr Lys Cys Gln Glu Cys Asn Asn Val Ile Lys Thr Cys 
225                 230                 235                 240 


Ser Val Leu Thr Lys Asn Arg Ile Tyr Ala Gly Gly Glu His Tyr Arg 
                245                 250                 255     


Cys Glu Glu Phe Gly Lys Val Phe Asn Gln Cys Ser His Leu Thr Glu 
            260                 265                 270         


His Glu His Gly Thr Glu Glu Lys Pro Cys Lys Tyr Glu Glu Cys Ser 
        275                 280                 285             


Ser Val Phe Ile Ser Cys Ser Ser Leu Ser Asn Gln Gln Met Ile Leu 
    290                 295                 300                 


Ala Gly Glu Lys Leu Ser Lys Cys Glu Thr Trp Tyr Lys Gly Phe Asn 
305                 310                 315                 320 


His Ser Pro Asn Pro Ser Lys His Gln Arg Asn Glu Ile Gly Gly Lys 
                325                 330                 335     


Pro Phe Lys Cys Glu Glu Cys Asp Ser Ile Phe Lys Trp Phe Ser Asp 
            340                 345                 350         


Leu Thr Lys His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys 
        355                 360                 365             


Asp Glu Cys Gly Lys Ala Tyr Thr Gln Ser Ser His Leu Ser Glu His 
    370                 375                 380                 


Arg Arg Ile His Thr Gly Glu Lys Pro Tyr Gln Cys Glu Glu Cys Gly 
385                 390                 395                 400 


Lys Val Phe Arg Thr Cys Ser Ser Leu Ser Asn His Lys Arg Thr His 
                405                 410                 415     


Ser Glu Glu Lys Pro Tyr Thr Cys Glu Glu Cys Gly Asn Ile Phe Lys 
            420                 425                 430         


Gln Leu Ser Asp Leu Thr Lys His Lys Lys Thr His Thr Gly Glu Lys 
        435                 440                 445             


Pro Tyr Lys Cys Asp Glu Cys Gly Lys Asn Phe Thr Gln Ser Ser Asn 
    450                 455                 460                 


Leu Ile Val His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys 
465                 470                 475                 480 


Glu Glu Cys Gly Arg Val Phe Met Trp Phe Ser Asp Ile Thr Lys His 
                485                 490                 495     


Lys Lys Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly 
            500                 505                 510         


Lys Asn Phe Thr Gln Ser Ser Asn Leu Ile Val His Lys Arg Ile His 
        515                 520                 525             


Thr Gly Glu Lys Pro Tyr Lys Cys Glu Lys Cys Gly Lys Ala Phe Thr 
    530                 535                 540                 


Gln Phe Ser His Leu Thr Val His Glu Ser Ile His Thr 
545                 550                 555         

<210>  2612
<211>  3190
<212>  DNA
<213>  Homo sapiens

<400>  2612
gtcccgacag agctccactt cctgtccccg cggctctgtg tcccctgcta gccgtaggtc     60

gtgtgacccg caggcaccgg gagatccaga agtgaaacgc caggctctct ggaggccagg    120

agatgactct gttgacgttc agggatgtgg ccatagaatt ctccctggag gagtggaaat    180

gcctggacct cgctcagcag aatttgtaca gggatgtgat gttggagaac tacagaaact    240

tgttctccgt tggtctcact gtctgtaagc caggcctgat cacctgcctg gagcaacgaa    300

aagagccctg gaatgtgaag agacaggagg cagcagacgg acatccaggc tggaagtgca    360

gtggtgtgat cgtggctcac tgcggcctcc acttcccagg ttcagagatg ggatttcacc    420

atgctactca ggcttgtctt gaactcctgg gctcaagcga tctgcctgcc tcagcctccc    480

aaagtgctgg gattacaggt gtgaaccacc gtgcccagcc aggcctcaat gtttctgtgg    540

acaaattcac tgctatgtct tctcatttta cccaagacct tctgccagag cagggcatac    600

aagatgcatt cccaaaaaga atactgagag gatatggaaa ttgtggcctt gataatttat    660

atttaaggaa agactgggaa agtttagatg agtgtaagtt gcaaaaagat tataatggac    720

ttaaccaatg ttcatcaact acccatagca aaatctttca atataataaa tatgttaaaa    780

tctttgataa cttttcaaat ttacatagac gtaatataag taatactgga gagaaacctt    840

tcaaatgtca agaatgtggc aaatcctttc aaatgctctc attcctaact gaacatcaga    900

aaattcacac tggaaaaaaa ttccaaaaat gtggagaatg tggcaaaacc tttatccagt    960

gctcacactt tactgaacct gagaacattg acactggaga gaaaccttac aagtgtcaag   1020

aatgtaacaa cgtcattaaa acttgctcag tccttactaa aaatagaatt tatgccggag   1080

gggaacatta cagatgtgaa gaatttggca aagtatttaa ccagtgctcc caccttactg   1140

aacatgagca tggtactgag gaaaaaccct gcaaatatga agagtgcagc agtgtcttta   1200

tctcttgctc aagcctttct aatcaacaga tgattcttgc tggagagaag ctctccaaat   1260

gtgaaacatg gtacaaaggt tttaaccaca gcccaaatcc ttccaaacac cagagaaatg   1320

agattggagg gaaacctttc aaatgtgagg aatgtgacag catcttcaag tggttctcag   1380

accttactaa acataagaga attcacactg gtgagaaacc atacaaatgt gacgaatgtg   1440

ggaaagccta tacacagtcc tcacacctca gtgaacacag gaggattcac accggagaga   1500

aaccctacca atgtgaagaa tgtgggaagg tcttcagaac ttgctcaagc ctttctaacc   1560

ataagagaac tcattctgaa gaaaaaccct acacgtgtga agaatgtggc aacatcttta   1620

agcagttatc agacctcact aagcataaga aaacccatac tggagagaag ccctacaaat   1680

gtgacgaatg tggaaaaaac tttacccagt cctccaacct tattgtacat aagagaattc   1740

atactggaga gaaaccctac aagtgtgaag aatgtggcag agtcttcatg tggttctcag   1800

acattaccaa acataagaaa acccatactg gagagaaacc ctacaaatgt gacgaatgtg   1860

gaaaaaactt tacccagtcc tcaaacctta ttgtacataa gagaattcat actggagaga   1920

aaccctacaa gtgtgaaaag tgtggcaaag ccttcaccca gttctcacac ctgactgtac   1980

atgaaagcat tcatacttga gaaaaaaata aacaaatata aaaataggca aagccgttag   2040

tatctgctcg catcccactt tacatcagag ttcagactta ataaagttat cataaatgta   2100

attactattg aaagaccttt catgaaatat aagtctccag agcacacaag agtatttctt   2160

ctgaaaaaaa tgttacaatt atactagatg gaagacttgc atcagttgct taaactttca   2220

gaaaatttgt agagaaaccc aacaaatctc ataaatgtgg aataacattt gttcaaaaat   2280

gatagcttag aaaacactag agttcatact aaaagatatt ttgcaaatac actaaatggg   2340

aaaaataagc aaggacacgt tcagaaatga cactgaatcc ctgtgttgag tctacagaga   2400

catctagact taaaatagat catttatatt taagtttaaa aggaggatga gactgagttt   2460

ttgtagagtt ataattacat tcaaaatata cttttttgca ttgaaaaaat gttaaatttt   2520

tgaaaagcga atattgatgt cattctattc tcaaatcagt agatgctgtg tcttcatttc   2580

tagtgctgat gtgaaaacac atggtcagtt gttgctgcgt cagagatatg agaaattctt   2640

ttctcttagg tgtgcatcac tgatatactt gtccgtgaaa ggtgaaagac actgaaatgt   2700

aagatgcgtg agtaaaatct tggtagagag gctctttgtg gttgttttat atacttgtaa   2760

gtgatttatg agataggtgt ttagaataat actcttctgt tagggtcacc ctgatcagac   2820

cgttcccttc ccctcccaca ggacttacaa tacggtccct tgtgctctct gcacagctac   2880

cccagggcaa aaaacaaacc ccccttcact gatccctcca gtaactgtgc agacagttac   2940

aggatgcggt taacatgtct gttcacctcg cataacaaag ctggcaaaaa acatctccag   3000

gatgcagaca agacacctgc accctcgact aagctccccc accccaaccc agttctcctg   3060

cacccccaac tcagctcccg caccccgacc tagttctggc cctataaaaa cctgctatag   3120

tctgtaagca gggctgcctc ctctaactgt ggtggagcag ccaagcagct caataaagct   3180

tgcttgcctg                                                          3190


<210>  2613
<211>  625
<212>  PRT
<213>  Homo sapiens

<400>  2613


Met Thr Leu Leu Thr Phe Arg Asp Val Ala Ile Glu Phe Ser Leu Glu 
1               5                   10                  15      


Glu Trp Lys Cys Leu Asp Leu Ala Gln Gln Asn Leu Tyr Arg Asp Val 
            20                  25                  30          


Met Leu Glu Asn Tyr Arg Asn Leu Phe Ser Val Gly Leu Thr Val Cys 
        35                  40                  45              


Lys Pro Gly Leu Ile Thr Cys Leu Glu Gln Arg Lys Glu Pro Trp Asn 
    50                  55                  60                  


Val Lys Arg Gln Glu Ala Ala Asp Gly His Pro Gly Trp Lys Cys Ser 
65                  70                  75                  80  


Gly Val Ile Val Ala His Cys Gly Leu His Phe Pro Gly Ser Glu Met 
                85                  90                  95      


Gly Phe His His Ala Thr Gln Ala Cys Leu Glu Leu Leu Gly Ser Ser 
            100                 105                 110         


Asp Leu Pro Ala Ser Ala Ser Gln Ser Ala Gly Ile Thr Gly Val Asn 
        115                 120                 125             


His Arg Ala Gln Pro Gly Leu Asn Val Ser Val Asp Lys Phe Thr Ala 
    130                 135                 140                 


Met Ser Ser His Phe Thr Gln Asp Leu Leu Pro Glu Gln Gly Ile Gln 
145                 150                 155                 160 


Asp Ala Phe Pro Lys Arg Ile Leu Arg Gly Tyr Gly Asn Cys Gly Leu 
                165                 170                 175     


Asp Asn Leu Tyr Leu Arg Lys Asp Trp Glu Ser Leu Asp Glu Cys Lys 
            180                 185                 190         


Leu Gln Lys Asp Tyr Asn Gly Leu Asn Gln Cys Ser Ser Thr Thr His 
        195                 200                 205             


Ser Lys Ile Phe Gln Tyr Asn Lys Tyr Val Lys Ile Phe Asp Asn Phe 
    210                 215                 220                 


Ser Asn Leu His Arg Arg Asn Ile Ser Asn Thr Gly Glu Lys Pro Phe 
225                 230                 235                 240 


Lys Cys Gln Glu Cys Gly Lys Ser Phe Gln Met Leu Ser Phe Leu Thr 
                245                 250                 255     


Glu His Gln Lys Ile His Thr Gly Lys Lys Phe Gln Lys Cys Gly Glu 
            260                 265                 270         


Cys Gly Lys Thr Phe Ile Gln Cys Ser His Phe Thr Glu Pro Glu Asn 
        275                 280                 285             


Ile Asp Thr Gly Glu Lys Pro Tyr Lys Cys Gln Glu Cys Asn Asn Val 
    290                 295                 300                 


Ile Lys Thr Cys Ser Val Leu Thr Lys Asn Arg Ile Tyr Ala Gly Gly 
305                 310                 315                 320 


Glu His Tyr Arg Cys Glu Glu Phe Gly Lys Val Phe Asn Gln Cys Ser 
                325                 330                 335     


His Leu Thr Glu His Glu His Gly Thr Glu Glu Lys Pro Cys Lys Tyr 
            340                 345                 350         


Glu Glu Cys Ser Ser Val Phe Ile Ser Cys Ser Ser Leu Ser Asn Gln 
        355                 360                 365             


Gln Met Ile Leu Ala Gly Glu Lys Leu Ser Lys Cys Glu Thr Trp Tyr 
    370                 375                 380                 


Lys Gly Phe Asn His Ser Pro Asn Pro Ser Lys His Gln Arg Asn Glu 
385                 390                 395                 400 


Ile Gly Gly Lys Pro Phe Lys Cys Glu Glu Cys Asp Ser Ile Phe Lys 
                405                 410                 415     


Trp Phe Ser Asp Leu Thr Lys His Lys Arg Ile His Thr Gly Glu Lys 
            420                 425                 430         


Pro Tyr Lys Cys Asp Glu Cys Gly Lys Ala Tyr Thr Gln Ser Ser His 
        435                 440                 445             


Leu Ser Glu His Arg Arg Ile His Thr Gly Glu Lys Pro Tyr Gln Cys 
    450                 455                 460                 


Glu Glu Cys Gly Lys Val Phe Arg Thr Cys Ser Ser Leu Ser Asn His 
465                 470                 475                 480 


Lys Arg Thr His Ser Glu Glu Lys Pro Tyr Thr Cys Glu Glu Cys Gly 
                485                 490                 495     


Asn Ile Phe Lys Gln Leu Ser Asp Leu Thr Lys His Lys Lys Thr His 
            500                 505                 510         


Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly Lys Asn Phe Thr 
        515                 520                 525             


Gln Ser Ser Asn Leu Ile Val His Lys Arg Ile His Thr Gly Glu Lys 
    530                 535                 540                 


Pro Tyr Lys Cys Glu Glu Cys Gly Arg Val Phe Met Trp Phe Ser Asp 
545                 550                 555                 560 


Ile Thr Lys His Lys Lys Thr His Thr Gly Glu Lys Pro Tyr Lys Cys 
                565                 570                 575     


Asp Glu Cys Gly Lys Asn Phe Thr Gln Ser Ser Asn Leu Ile Val His 
            580                 585                 590         


Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Lys Cys Gly 
        595                 600                 605             


Lys Ala Phe Thr Gln Phe Ser His Leu Thr Val His Glu Ser Ile His 
    610                 615                 620                 


Thr 
625 

<210>  2614
<211>  3132
<212>  DNA
<213>  Homo sapiens

<400>  2614
gtcccgacag agctccactt cctgtccccg cggctctgtg tcccctgcta gccgtaggtc     60

gtgtgacccg caggcaccgg gagatccaga agtgaaacgc caggctctct ggaggccagg    120

agatgactct gttgacgttc agggatgtgg ccatagaatt ctccctggag gagtggaaat    180

gcctggacct cgctcagcag aatttgtaca gggatgtgat gttggagaac tacagaaact    240

tgttctccgt tggtctcact gtctgtaagc caggcctgat cacctgcctg gagcaacgaa    300

aagagccctg gaatgtgaag agacaggagg cagcagacgg acatccagca tccgcaaacg    360

tttagcttgt ctttatatct tgacaattgt gaataatgct gcagtgaaca tgagggagca    420

gataattctt caagatgctg cttttattcc cttcagttat tatatacaca gaagtgtgat    480

tgctgcgttg caggctatgt cttctcattt tacccaagac cttctgccag agcagggcat    540

acaagatgca ttcccaaaaa gaatactgag aggatatgga aattgtggcc ttgataattt    600

atatttaagg aaagactggg aaagtttaga tgagtgtaag ttgcaaaaag attataatgg    660

acttaaccaa tgttcatcaa ctacccatag caaaatcttt caatataata aatatgttaa    720

aatctttgat aacttttcaa atttacatag acgtaatata agtaatactg gagagaaacc    780

tttcaaatgt caagaatgtg gcaaatcctt tcaaatgctc tcattcctaa ctgaacatca    840

gaaaattcac actggaaaaa aattccaaaa atgtggagaa tgtggcaaaa cctttatcca    900

gtgctcacac tttactgaac ctgagaacat tgacactgga gagaaacctt acaagtgtca    960

agaatgtaac aacgtcatta aaacttgctc agtccttact aaaaatagaa tttatgccgg   1020

aggggaacat tacagatgtg aagaatttgg caaagtattt aaccagtgct cccaccttac   1080

tgaacatgag catggtactg aggaaaaacc ctgcaaatat gaagagtgca gcagtgtctt   1140

tatctcttgc tcaagccttt ctaatcaaca gatgattctt gctggagaga agctctccaa   1200

atgtgaaaca tggtacaaag gttttaacca cagcccaaat ccttccaaac accagagaaa   1260

tgagattgga gggaaacctt tcaaatgtga ggaatgtgac agcatcttca agtggttctc   1320

agaccttact aaacataaga gaattcacac tggtgagaaa ccatacaaat gtgacgaatg   1380

tgggaaagcc tatacacagt cctcacacct cagtgaacac aggaggattc acaccggaga   1440

gaaaccctac caatgtgaag aatgtgggaa ggtcttcaga acttgctcaa gcctttctaa   1500

ccataagaga actcattctg aagaaaaacc ctacacgtgt gaagaatgtg gcaacatctt   1560

taagcagtta tcagacctca ctaagcataa gaaaacccat actggagaga agccctacaa   1620

atgtgacgaa tgtggaaaaa actttaccca gtcctccaac cttattgtac ataagagaat   1680

tcatactgga gagaaaccct acaagtgtga agaatgtggc agagtcttca tgtggttctc   1740

agacattacc aaacataaga aaacccatac tggagagaaa ccctacaaat gtgacgaatg   1800

tggaaaaaac tttacccagt cctcaaacct tattgtacat aagagaattc atactggaga   1860

gaaaccctac aagtgtgaaa agtgtggcaa agccttcacc cagttctcac acctgactgt   1920

acatgaaagc attcatactt gagaaaaaaa taaacaaata taaaaatagg caaagccgtt   1980

agtatctgct cgcatcccac tttacatcag agttcagact taataaagtt atcataaatg   2040

taattactat tgaaagacct ttcatgaaat ataagtctcc agagcacaca agagtatttc   2100

ttctgaaaaa aatgttacaa ttatactaga tggaagactt gcatcagttg cttaaacttt   2160

cagaaaattt gtagagaaac ccaacaaatc tcataaatgt ggaataacat ttgttcaaaa   2220

atgatagctt agaaaacact agagttcata ctaaaagata ttttgcaaat acactaaatg   2280

ggaaaaataa gcaaggacac gttcagaaat gacactgaat ccctgtgttg agtctacaga   2340

gacatctaga cttaaaatag atcatttata tttaagttta aaaggaggat gagactgagt   2400

ttttgtagag ttataattac attcaaaata tacttttttg cattgaaaaa atgttaaatt   2460

tttgaaaagc gaatattgat gtcattctat tctcaaatca gtagatgctg tgtcttcatt   2520

tctagtgctg atgtgaaaac acatggtcag ttgttgctgc gtcagagata tgagaaattc   2580

ttttctctta ggtgtgcatc actgatatac ttgtccgtga aaggtgaaag acactgaaat   2640

gtaagatgcg tgagtaaaat cttggtagag aggctctttg tggttgtttt atatacttgt   2700

aagtgattta tgagataggt gtttagaata atactcttct gttagggtca ccctgatcag   2760

accgttccct tcccctccca caggacttac aatacggtcc cttgtgctct ctgcacagct   2820

accccagggc aaaaaacaaa ccccccttca ctgatccctc cagtaactgt gcagacagtt   2880

acaggatgcg gttaacatgt ctgttcacct cgcataacaa agctggcaaa aaacatctcc   2940

aggatgcaga caagacacct gcaccctcga ctaagctccc ccaccccaac ccagttctcc   3000

tgcaccccca actcagctcc cgcaccccga cctagttctg gccctataaa aacctgctat   3060

agtctgtaag cagggctgcc tcctctaact gtggtggagc agccaagcag ctcaataaag   3120

cttgcttgcc tg                                                       3132


<210>  2615
<211>  510
<212>  PRT
<213>  Homo sapiens

<400>  2615


Met Arg Glu Gln Ile Ile Leu Gln Asp Ala Ala Phe Ile Pro Phe Ser 
1               5                   10                  15      


Tyr Tyr Ile His Arg Ser Val Ile Ala Ala Leu Gln Ala Met Ser Ser 
            20                  25                  30          


His Phe Thr Gln Asp Leu Leu Pro Glu Gln Gly Ile Gln Asp Ala Phe 
        35                  40                  45              


Pro Lys Arg Ile Leu Arg Gly Tyr Gly Asn Cys Gly Leu Asp Asn Leu 
    50                  55                  60                  


Tyr Leu Arg Lys Asp Trp Glu Ser Leu Asp Glu Cys Lys Leu Gln Lys 
65                  70                  75                  80  


Asp Tyr Asn Gly Leu Asn Gln Cys Ser Ser Thr Thr His Ser Lys Ile 
                85                  90                  95      


Phe Gln Tyr Asn Lys Tyr Val Lys Ile Phe Asp Asn Phe Ser Asn Leu 
            100                 105                 110         


His Arg Arg Asn Ile Ser Asn Thr Gly Glu Lys Pro Phe Lys Cys Gln 
        115                 120                 125             


Glu Cys Gly Lys Ser Phe Gln Met Leu Ser Phe Leu Thr Glu His Gln 
    130                 135                 140                 


Lys Ile His Thr Gly Lys Lys Phe Gln Lys Cys Gly Glu Cys Gly Lys 
145                 150                 155                 160 


Thr Phe Ile Gln Cys Ser His Phe Thr Glu Pro Glu Asn Ile Asp Thr 
                165                 170                 175     


Gly Glu Lys Pro Tyr Lys Cys Gln Glu Cys Asn Asn Val Ile Lys Thr 
            180                 185                 190         


Cys Ser Val Leu Thr Lys Asn Arg Ile Tyr Ala Gly Gly Glu His Tyr 
        195                 200                 205             


Arg Cys Glu Glu Phe Gly Lys Val Phe Asn Gln Cys Ser His Leu Thr 
    210                 215                 220                 


Glu His Glu His Gly Thr Glu Glu Lys Pro Cys Lys Tyr Glu Glu Cys 
225                 230                 235                 240 


Ser Ser Val Phe Ile Ser Cys Ser Ser Leu Ser Asn Gln Gln Met Ile 
                245                 250                 255     


Leu Ala Gly Glu Lys Leu Ser Lys Cys Glu Thr Trp Tyr Lys Gly Phe 
            260                 265                 270         


Asn His Ser Pro Asn Pro Ser Lys His Gln Arg Asn Glu Ile Gly Gly 
        275                 280                 285             


Lys Pro Phe Lys Cys Glu Glu Cys Asp Ser Ile Phe Lys Trp Phe Ser 
    290                 295                 300                 


Asp Leu Thr Lys His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys 
305                 310                 315                 320 


Cys Asp Glu Cys Gly Lys Ala Tyr Thr Gln Ser Ser His Leu Ser Glu 
                325                 330                 335     


His Arg Arg Ile His Thr Gly Glu Lys Pro Tyr Gln Cys Glu Glu Cys 
            340                 345                 350         


Gly Lys Val Phe Arg Thr Cys Ser Ser Leu Ser Asn His Lys Arg Thr 
        355                 360                 365             


His Ser Glu Glu Lys Pro Tyr Thr Cys Glu Glu Cys Gly Asn Ile Phe 
    370                 375                 380                 


Lys Gln Leu Ser Asp Leu Thr Lys His Lys Lys Thr His Thr Gly Glu 
385                 390                 395                 400 


Lys Pro Tyr Lys Cys Asp Glu Cys Gly Lys Asn Phe Thr Gln Ser Ser 
                405                 410                 415     


Asn Leu Ile Val His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys 
            420                 425                 430         


Cys Glu Glu Cys Gly Arg Val Phe Met Trp Phe Ser Asp Ile Thr Lys 
        435                 440                 445             


His Lys Lys Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys 
    450                 455                 460                 


Gly Lys Asn Phe Thr Gln Ser Ser Asn Leu Ile Val His Lys Arg Ile 
465                 470                 475                 480 


His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Lys Cys Gly Lys Ala Phe 
                485                 490                 495     


Thr Gln Phe Ser His Leu Thr Val His Glu Ser Ile His Thr 
            500                 505                 510 

<210>  2616
<211>  2752
<212>  DNA
<213>  Homo sapiens

<400>  2616
ttccgggatc tagcggggcc tttgtcccga cagagctcca cttcctgtcc ccgcggctct     60

gtgtcccctg ctagccgtag gtcgtgtgac ccgcaggcac cgggagatcc agaactatgt    120

cttctcattt tacccaagac cttctgccag agcagggcat acaagatgca ttcccaaaaa    180

gaatactgag aggatatgga aattgtggcc ttgataattt atatttaagg aaagactggg    240

aaagtttaga tgagtgtaag ttgcaaaaag attataatgg acttaaccaa tgttcatcaa    300

ctacccatag caaaatcttt caatataata aatatgttaa aatctttgat aacttttcaa    360

atttacatag acgtaatata agtaatactg gagagaaacc tttcaaatgt caagaatgtg    420

gcaaatcctt tcaaatgctc tcattcctaa ctgaacatca gaaaattcac actggaaaaa    480

aattccaaaa atgtggagaa tgtggcaaaa cctttatcca gtgctcacac tttactgaac    540

ctgagaacat tgacactgga gagaaacctt acaagtgtca agaatgtaac aacgtcatta    600

aaacttgctc agtccttact aaaaatagaa tttatgccgg aggggaacat tacagatgtg    660

aagaatttgg caaagtattt aaccagtgct cccaccttac tgaacatgag catggtactg    720

aggaaaaacc ctgcaaatat gaagagtgca gcagtgtctt tatctcttgc tcaagccttt    780

ctaatcaaca gatgattctt gctggagaga agctctccaa atgtgaaaca tggtacaaag    840

gttttaacca cagcccaaat ccttccaaac accagagaaa tgagattgga gggaaacctt    900

tcaaatgtga ggaatgtgac agcatcttca agtggttctc agaccttact aaacataaga    960

gaattcacac tggtgagaaa ccatacaaat gtgacgaatg tgggaaagcc tatacacagt   1020

cctcacacct cagtgaacac aggaggattc acaccggaga gaaaccctac caatgtgaag   1080

aatgtgggaa ggtcttcaga acttgctcaa gcctttctaa ccataagaga actcattctg   1140

aagaaaaacc ctacacgtgt gaagaatgtg gcaacatctt taagcagtta tcagacctca   1200

ctaagcataa gaaaacccat actggagaga agccctacaa atgtgacgaa tgtggaaaaa   1260

actttaccca gtcctccaac cttattgtac ataagagaat tcatactgga gagaaaccct   1320

acaagtgtga agaatgtggc agagtcttca tgtggttctc agacattacc aaacataaga   1380

aaacccatac tggagagaaa ccctacaaat gtgacgaatg tggaaaaaac tttacccagt   1440

cctcaaacct tattgtacat aagagaattc atactggaga gaaaccctac aagtgtgaaa   1500

agtgtggcaa agccttcacc cagttctcac acctgactgt acatgaaagc attcatactt   1560

gagaaaaaaa taaacaaata taaaaatagg caaagccgtt agtatctgct cgcatcccac   1620

tttacatcag agttcagact taataaagtt atcataaatg taattactat tgaaagacct   1680

ttcatgaaat ataagtctcc agagcacaca agagtatttc ttctgaaaaa aatgttacaa   1740

ttatactaga tggaagactt gcatcagttg cttaaacttt cagaaaattt gtagagaaac   1800

ccaacaaatc tcataaatgt ggaataacat ttgttcaaaa atgatagctt agaaaacact   1860

agagttcata ctaaaagata ttttgcaaat acactaaatg ggaaaaataa gcaaggacac   1920

gttcagaaat gacactgaat ccctgtgttg agtctacaga gacatctaga cttaaaatag   1980

atcatttata tttaagttta aaaggaggat gagactgagt ttttgtagag ttataattac   2040

attcaaaata tacttttttg cattgaaaaa atgttaaatt tttgaaaagc gaatattgat   2100

gtcattctat tctcaaatca gtagatgctg tgtcttcatt tctagtgctg atgtgaaaac   2160

acatggtcag ttgttgctgc gtcagagata tgagaaattc ttttctctta ggtgtgcatc   2220

actgatatac ttgtccgtga aaggtgaaag acactgaaat gtaagatgcg tgagtaaaat   2280

cttggtagag aggctctttg tggttgtttt atatacttgt aagtgattta tgagataggt   2340

gtttagaata atactcttct gttagggtca ccctgatcag accgttccct tcccctccca   2400

caggacttac aatacggtcc cttgtgctct ctgcacagct accccagggc aaaaaacaaa   2460

ccccccttca ctgatccctc cagtaactgt gcagacagtt acaggatgcg gttaacatgt   2520

ctgttcacct cgcataacaa agctggcaaa aaacatctcc aggatgcaga caagacacct   2580

gcaccctcga ctaagctccc ccaccccaac ccagttctcc tgcaccccca actcagctcc   2640

cgcaccccga cctagttctg gccctataaa aacctgctat agtctgtaag cagggctgcc   2700

tcctctaact gtggtggagc agccaagcag ctcaataaag cttgcttgcc tg           2752


<210>  2617
<211>  481
<212>  PRT
<213>  Homo sapiens

<400>  2617


Met Ser Ser His Phe Thr Gln Asp Leu Leu Pro Glu Gln Gly Ile Gln 
1               5                   10                  15      


Asp Ala Phe Pro Lys Arg Ile Leu Arg Gly Tyr Gly Asn Cys Gly Leu 
            20                  25                  30          


Asp Asn Leu Tyr Leu Arg Lys Asp Trp Glu Ser Leu Asp Glu Cys Lys 
        35                  40                  45              


Leu Gln Lys Asp Tyr Asn Gly Leu Asn Gln Cys Ser Ser Thr Thr His 
    50                  55                  60                  


Ser Lys Ile Phe Gln Tyr Asn Lys Tyr Val Lys Ile Phe Asp Asn Phe 
65                  70                  75                  80  


Ser Asn Leu His Arg Arg Asn Ile Ser Asn Thr Gly Glu Lys Pro Phe 
                85                  90                  95      


Lys Cys Gln Glu Cys Gly Lys Ser Phe Gln Met Leu Ser Phe Leu Thr 
            100                 105                 110         


Glu His Gln Lys Ile His Thr Gly Lys Lys Phe Gln Lys Cys Gly Glu 
        115                 120                 125             


Cys Gly Lys Thr Phe Ile Gln Cys Ser His Phe Thr Glu Pro Glu Asn 
    130                 135                 140                 


Ile Asp Thr Gly Glu Lys Pro Tyr Lys Cys Gln Glu Cys Asn Asn Val 
145                 150                 155                 160 


Ile Lys Thr Cys Ser Val Leu Thr Lys Asn Arg Ile Tyr Ala Gly Gly 
                165                 170                 175     


Glu His Tyr Arg Cys Glu Glu Phe Gly Lys Val Phe Asn Gln Cys Ser 
            180                 185                 190         


His Leu Thr Glu His Glu His Gly Thr Glu Glu Lys Pro Cys Lys Tyr 
        195                 200                 205             


Glu Glu Cys Ser Ser Val Phe Ile Ser Cys Ser Ser Leu Ser Asn Gln 
    210                 215                 220                 


Gln Met Ile Leu Ala Gly Glu Lys Leu Ser Lys Cys Glu Thr Trp Tyr 
225                 230                 235                 240 


Lys Gly Phe Asn His Ser Pro Asn Pro Ser Lys His Gln Arg Asn Glu 
                245                 250                 255     


Ile Gly Gly Lys Pro Phe Lys Cys Glu Glu Cys Asp Ser Ile Phe Lys 
            260                 265                 270         


Trp Phe Ser Asp Leu Thr Lys His Lys Arg Ile His Thr Gly Glu Lys 
        275                 280                 285             


Pro Tyr Lys Cys Asp Glu Cys Gly Lys Ala Tyr Thr Gln Ser Ser His 
    290                 295                 300                 


Leu Ser Glu His Arg Arg Ile His Thr Gly Glu Lys Pro Tyr Gln Cys 
305                 310                 315                 320 


Glu Glu Cys Gly Lys Val Phe Arg Thr Cys Ser Ser Leu Ser Asn His 
                325                 330                 335     


Lys Arg Thr His Ser Glu Glu Lys Pro Tyr Thr Cys Glu Glu Cys Gly 
            340                 345                 350         


Asn Ile Phe Lys Gln Leu Ser Asp Leu Thr Lys His Lys Lys Thr His 
        355                 360                 365             


Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly Lys Asn Phe Thr 
    370                 375                 380                 


Gln Ser Ser Asn Leu Ile Val His Lys Arg Ile His Thr Gly Glu Lys 
385                 390                 395                 400 


Pro Tyr Lys Cys Glu Glu Cys Gly Arg Val Phe Met Trp Phe Ser Asp 
                405                 410                 415     


Ile Thr Lys His Lys Lys Thr His Thr Gly Glu Lys Pro Tyr Lys Cys 
            420                 425                 430         


Asp Glu Cys Gly Lys Asn Phe Thr Gln Ser Ser Asn Leu Ile Val His 
        435                 440                 445             


Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Lys Cys Gly 
    450                 455                 460                 


Lys Ala Phe Thr Gln Phe Ser His Leu Thr Val His Glu Ser Ile His 
465                 470                 475                 480 


Thr 
    

<210>  2618
<211>  3257
<212>  DNA
<213>  Homo sapiens

<400>  2618
atcaggcaca tgtctggaga ggagaggacg gcttccggga tctagcgggg cctttgtccc     60

gacagagctc cacttcctgt ccccgcggct ctgtgtcccc tgctagccgt aggtcgtgtg    120

acccgcaggc accgggagat ccagaagtga aacgccaggc tctctggagg ccaggagatg    180

actctgttga cgttcaggga tgtggccata gaattctccc tggaggagtg gaaatgcctg    240

gacctcgctc agcagaattt gtacagggat gtgatgttgg agaactacag aaacttgttc    300

tccgttggtc tcactgtctg taagccaggc ctgatcacct gcctggagca acgaaaagag    360

ccctggaatg tgaagagaca ggaggcagca gacggacatc cagagatggg atttcaccat    420

gctactcagg cttgtcttga actcctgggc tcaagcgatc tgcctgcctc agcctcccaa    480

agtgctggga ttacaggtgt gaaccaccgt gcccagccag gcctcaatgt ttctgtggac    540

aaattcactg cactgtgctc acctggggtg ctgcaaactg tgaaatggtt tttagagttc    600

agatgcatct tctcactagc tatgtcttct cattttaccc aagaccttct gccagagcag    660

ggcatacaag atgcattccc aaaaagaata ctgagaggat atggaaattg tggccttgat    720

aatttatatt taaggaaaga ctgggaaagt ttagatgagt gtaagttgca aaaagattat    780

aatggactta accaatgttc atcaactacc catagcaaaa tctttcaata taataaatat    840

gttaaaatct ttgataactt ttcaaattta catagacgta atataagtaa tactggagag    900

aaacctttca aatgtcaaga atgtggcaaa tcctttcaaa tgctctcatt cctaactgaa    960

catcagaaaa ttcacactgg aaaaaaattc caaaaatgtg gagaatgtgg caaaaccttt   1020

atccagtgct cacactttac tgaacctgag aacattgaca ctggagagaa accttacaag   1080

tgtcaagaat gtaacaacgt cattaaaact tgctcagtcc ttactaaaaa tagaatttat   1140

gccggagggg aacattacag atgtgaagaa tttggcaaag tatttaacca gtgctcccac   1200

cttactgaac atgagcatgg tactgaggaa aaaccctgca aatatgaaga gtgcagcagt   1260

gtctttatct cttgctcaag cctttctaat caacagatga ttcttgctgg agagaagctc   1320

tccaaatgtg aaacatggta caaaggtttt aaccacagcc caaatccttc caaacaccag   1380

agaaatgaga ttggagggaa acctttcaaa tgtgaggaat gtgacagcat cttcaagtgg   1440

ttctcagacc ttactaaaca taagagaatt cacactggtg agaaaccata caaatgtgac   1500

gaatgtggga aagcctatac acagtcctca cacctcagtg aacacaggag gattcacacc   1560

ggagagaaac cctaccaatg tgaagaatgt gggaaggtct tcagaacttg ctcaagcctt   1620

tctaaccata agagaactca ttctgaagaa aaaccctaca cgtgtgaaga atgtggcaac   1680

atctttaagc agttatcaga cctcactaag cataagaaaa cccatactgg agagaagccc   1740

tacaaatgtg acgaatgtgg aaaaaacttt acccagtcct ccaaccttat tgtacataag   1800

agaattcata ctggagagaa accctacaag tgtgaagaat gtggcagagt cttcatgtgg   1860

ttctcagaca ttaccaaaca taagaaaacc catactggag agaaacccta caaatgtgac   1920

gaatgtggaa aaaactttac ccagtcctca aaccttattg tacataagag aattcatact   1980

ggagagaaac cctacaagtg tgaaaagtgt ggcaaagcct tcacccagtt ctcacacctg   2040

actgtacatg aaagcattca tacttgagaa aaaaataaac aaatataaaa ataggcaaag   2100

ccgttagtat ctgctcgcat cccactttac atcagagttc agacttaata aagttatcat   2160

aaatgtaatt actattgaaa gacctttcat gaaatataag tctccagagc acacaagagt   2220

atttcttctg aaaaaaatgt tacaattata ctagatggaa gacttgcatc agttgcttaa   2280

actttcagaa aatttgtaga gaaacccaac aaatctcata aatgtggaat aacatttgtt   2340

caaaaatgat agcttagaaa acactagagt tcatactaaa agatattttg caaatacact   2400

aaatgggaaa aataagcaag gacacgttca gaaatgacac tgaatccctg tgttgagtct   2460

acagagacat ctagacttaa aatagatcat ttatatttaa gtttaaaagg aggatgagac   2520

tgagtttttg tagagttata attacattca aaatatactt ttttgcattg aaaaaatgtt   2580

aaatttttga aaagcgaata ttgatgtcat tctattctca aatcagtaga tgctgtgtct   2640

tcatttctag tgctgatgtg aaaacacatg gtcagttgtt gctgcgtcag agatatgaga   2700

aattcttttc tcttaggtgt gcatcactga tatacttgtc cgtgaaaggt gaaagacact   2760

gaaatgtaag atgcgtgagt aaaatcttgg tagagaggct ctttgtggtt gttttatata   2820

cttgtaagtg atttatgaga taggtgttta gaataatact cttctgttag ggtcaccctg   2880

atcagaccgt tcccttcccc tcccacagga cttacaatac ggtcccttgt gctctctgca   2940

cagctacccc agggcaaaaa acaaaccccc cttcactgat ccctccagta actgtgcaga   3000

cagttacagg atgcggttaa catgtctgtt cacctcgcat aacaaagctg gcaaaaaaca   3060

tctccaggat gcagacaaga cacctgcacc ctcgactaag ctcccccacc ccaacccagt   3120

tctcctgcac ccccaactca gctcccgcac cccgacctag ttctggccct ataaaaacct   3180

gctatagtct gtaagcaggg ctgcctcctc taactgtggt ggagcagcca agcagctcaa   3240

taaagcttgc ttgcctg                                                  3257


<210>  2619
<211>  629
<212>  PRT
<213>  Homo sapiens

<400>  2619


Met Thr Leu Leu Thr Phe Arg Asp Val Ala Ile Glu Phe Ser Leu Glu 
1               5                   10                  15      


Glu Trp Lys Cys Leu Asp Leu Ala Gln Gln Asn Leu Tyr Arg Asp Val 
            20                  25                  30          


Met Leu Glu Asn Tyr Arg Asn Leu Phe Ser Val Gly Leu Thr Val Cys 
        35                  40                  45              


Lys Pro Gly Leu Ile Thr Cys Leu Glu Gln Arg Lys Glu Pro Trp Asn 
    50                  55                  60                  


Val Lys Arg Gln Glu Ala Ala Asp Gly His Pro Glu Met Gly Phe His 
65                  70                  75                  80  


His Ala Thr Gln Ala Cys Leu Glu Leu Leu Gly Ser Ser Asp Leu Pro 
                85                  90                  95      


Ala Ser Ala Ser Gln Ser Ala Gly Ile Thr Gly Val Asn His Arg Ala 
            100                 105                 110         


Gln Pro Gly Leu Asn Val Ser Val Asp Lys Phe Thr Ala Leu Cys Ser 
        115                 120                 125             


Pro Gly Val Leu Gln Thr Val Lys Trp Phe Leu Glu Phe Arg Cys Ile 
    130                 135                 140                 


Phe Ser Leu Ala Met Ser Ser His Phe Thr Gln Asp Leu Leu Pro Glu 
145                 150                 155                 160 


Gln Gly Ile Gln Asp Ala Phe Pro Lys Arg Ile Leu Arg Gly Tyr Gly 
                165                 170                 175     


Asn Cys Gly Leu Asp Asn Leu Tyr Leu Arg Lys Asp Trp Glu Ser Leu 
            180                 185                 190         


Asp Glu Cys Lys Leu Gln Lys Asp Tyr Asn Gly Leu Asn Gln Cys Ser 
        195                 200                 205             


Ser Thr Thr His Ser Lys Ile Phe Gln Tyr Asn Lys Tyr Val Lys Ile 
    210                 215                 220                 


Phe Asp Asn Phe Ser Asn Leu His Arg Arg Asn Ile Ser Asn Thr Gly 
225                 230                 235                 240 


Glu Lys Pro Phe Lys Cys Gln Glu Cys Gly Lys Ser Phe Gln Met Leu 
                245                 250                 255     


Ser Phe Leu Thr Glu His Gln Lys Ile His Thr Gly Lys Lys Phe Gln 
            260                 265                 270         


Lys Cys Gly Glu Cys Gly Lys Thr Phe Ile Gln Cys Ser His Phe Thr 
        275                 280                 285             


Glu Pro Glu Asn Ile Asp Thr Gly Glu Lys Pro Tyr Lys Cys Gln Glu 
    290                 295                 300                 


Cys Asn Asn Val Ile Lys Thr Cys Ser Val Leu Thr Lys Asn Arg Ile 
305                 310                 315                 320 


Tyr Ala Gly Gly Glu His Tyr Arg Cys Glu Glu Phe Gly Lys Val Phe 
                325                 330                 335     


Asn Gln Cys Ser His Leu Thr Glu His Glu His Gly Thr Glu Glu Lys 
            340                 345                 350         


Pro Cys Lys Tyr Glu Glu Cys Ser Ser Val Phe Ile Ser Cys Ser Ser 
        355                 360                 365             


Leu Ser Asn Gln Gln Met Ile Leu Ala Gly Glu Lys Leu Ser Lys Cys 
    370                 375                 380                 


Glu Thr Trp Tyr Lys Gly Phe Asn His Ser Pro Asn Pro Ser Lys His 
385                 390                 395                 400 


Gln Arg Asn Glu Ile Gly Gly Lys Pro Phe Lys Cys Glu Glu Cys Asp 
                405                 410                 415     


Ser Ile Phe Lys Trp Phe Ser Asp Leu Thr Lys His Lys Arg Ile His 
            420                 425                 430         


Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly Lys Ala Tyr Thr 
        435                 440                 445             


Gln Ser Ser His Leu Ser Glu His Arg Arg Ile His Thr Gly Glu Lys 
    450                 455                 460                 


Pro Tyr Gln Cys Glu Glu Cys Gly Lys Val Phe Arg Thr Cys Ser Ser 
465                 470                 475                 480 


Leu Ser Asn His Lys Arg Thr His Ser Glu Glu Lys Pro Tyr Thr Cys 
                485                 490                 495     


Glu Glu Cys Gly Asn Ile Phe Lys Gln Leu Ser Asp Leu Thr Lys His 
            500                 505                 510         


Lys Lys Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly 
        515                 520                 525             


Lys Asn Phe Thr Gln Ser Ser Asn Leu Ile Val His Lys Arg Ile His 
    530                 535                 540                 


Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Arg Val Phe Met 
545                 550                 555                 560 


Trp Phe Ser Asp Ile Thr Lys His Lys Lys Thr His Thr Gly Glu Lys 
                565                 570                 575     


Pro Tyr Lys Cys Asp Glu Cys Gly Lys Asn Phe Thr Gln Ser Ser Asn 
            580                 585                 590         


Leu Ile Val His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys 
        595                 600                 605             


Glu Lys Cys Gly Lys Ala Phe Thr Gln Phe Ser His Leu Thr Val His 
    610                 615                 620                 


Glu Ser Ile His Thr 
625                 

<210>  2620
<211>  3188
<212>  DNA
<213>  Homo sapiens

<400>  2620
atcaggcaca tgtctggaga ggagaggacg gcttccggga tctagcgggg cctttgtccc     60

gacagagctc cacttcctgt ccccgcggct ctgtgtcccc tgctagccgt aggtcgtgtg    120

acccgcaggc accgggagat ccagaagtga aacgccaggc tctctggagg ccaggagatg    180

actctgttga cgttcaggga tgtggccata gaattctccc tggaggagtg gaaatgcctg    240

gacctcgctc agcagaattt gtacagggat gtgatgttgg agaactacag aaacttgttc    300

tccgttggtc tcactgtctg taagccaggc ctgatcacct gcctggagca acgaaaagag    360

ccctggaatg tgaagagaca ggaggcagca gacggacatc cagagatggg atttcaccat    420

gctactcagg cttgtcttga actcctgggc tcaagcgatc tgcctgcctc agcctcccaa    480

agtgctggga ttacaggtgt gaaccaccgt gcccagccag gcctcaatgt ttctgtggac    540

aaattcactg ctatgtcttc tcattttacc caagaccttc tgccagagca gggcatacaa    600

gatgcattcc caaaaagaat actgagagga tatggaaatt gtggccttga taatttatat    660

ttaaggaaag actgggaaag tttagatgag tgtaagttgc aaaaagatta taatggactt    720

aaccaatgtt catcaactac ccatagcaaa atctttcaat ataataaata tgttaaaatc    780

tttgataact tttcaaattt acatagacgt aatataagta atactggaga gaaacctttc    840

aaatgtcaag aatgtggcaa atcctttcaa atgctctcat tcctaactga acatcagaaa    900

attcacactg gaaaaaaatt ccaaaaatgt ggagaatgtg gcaaaacctt tatccagtgc    960

tcacacttta ctgaacctga gaacattgac actggagaga aaccttacaa gtgtcaagaa   1020

tgtaacaacg tcattaaaac ttgctcagtc cttactaaaa atagaattta tgccggaggg   1080

gaacattaca gatgtgaaga atttggcaaa gtatttaacc agtgctccca ccttactgaa   1140

catgagcatg gtactgagga aaaaccctgc aaatatgaag agtgcagcag tgtctttatc   1200

tcttgctcaa gcctttctaa tcaacagatg attcttgctg gagagaagct ctccaaatgt   1260

gaaacatggt acaaaggttt taaccacagc ccaaatcctt ccaaacacca gagaaatgag   1320

attggaggga aacctttcaa atgtgaggaa tgtgacagca tcttcaagtg gttctcagac   1380

cttactaaac ataagagaat tcacactggt gagaaaccat acaaatgtga cgaatgtggg   1440

aaagcctata cacagtcctc acacctcagt gaacacagga ggattcacac cggagagaaa   1500

ccctaccaat gtgaagaatg tgggaaggtc ttcagaactt gctcaagcct ttctaaccat   1560

aagagaactc attctgaaga aaaaccctac acgtgtgaag aatgtggcaa catctttaag   1620

cagttatcag acctcactaa gcataagaaa acccatactg gagagaagcc ctacaaatgt   1680

gacgaatgtg gaaaaaactt tacccagtcc tccaacctta ttgtacataa gagaattcat   1740

actggagaga aaccctacaa gtgtgaagaa tgtggcagag tcttcatgtg gttctcagac   1800

attaccaaac ataagaaaac ccatactgga gagaaaccct acaaatgtga cgaatgtgga   1860

aaaaacttta cccagtcctc aaaccttatt gtacataaga gaattcatac tggagagaaa   1920

ccctacaagt gtgaaaagtg tggcaaagcc ttcacccagt tctcacacct gactgtacat   1980

gaaagcattc atacttgaga aaaaaataaa caaatataaa aataggcaaa gccgttagta   2040

tctgctcgca tcccacttta catcagagtt cagacttaat aaagttatca taaatgtaat   2100

tactattgaa agacctttca tgaaatataa gtctccagag cacacaagag tatttcttct   2160

gaaaaaaatg ttacaattat actagatgga agacttgcat cagttgctta aactttcaga   2220

aaatttgtag agaaacccaa caaatctcat aaatgtggaa taacatttgt tcaaaaatga   2280

tagcttagaa aacactagag ttcatactaa aagatatttt gcaaatacac taaatgggaa   2340

aaataagcaa ggacacgttc agaaatgaca ctgaatccct gtgttgagtc tacagagaca   2400

tctagactta aaatagatca tttatattta agtttaaaag gaggatgaga ctgagttttt   2460

gtagagttat aattacattc aaaatatact tttttgcatt gaaaaaatgt taaatttttg   2520

aaaagcgaat attgatgtca ttctattctc aaatcagtag atgctgtgtc ttcatttcta   2580

gtgctgatgt gaaaacacat ggtcagttgt tgctgcgtca gagatatgag aaattctttt   2640

ctcttaggtg tgcatcactg atatacttgt ccgtgaaagg tgaaagacac tgaaatgtaa   2700

gatgcgtgag taaaatcttg gtagagaggc tctttgtggt tgttttatat acttgtaagt   2760

gatttatgag ataggtgttt agaataatac tcttctgtta gggtcaccct gatcagaccg   2820

ttcccttccc ctcccacagg acttacaata cggtcccttg tgctctctgc acagctaccc   2880

cagggcaaaa aacaaacccc ccttcactga tccctccagt aactgtgcag acagttacag   2940

gatgcggtta acatgtctgt tcacctcgca taacaaagct ggcaaaaaac atctccagga   3000

tgcagacaag acacctgcac cctcgactaa gctcccccac cccaacccag ttctcctgca   3060

cccccaactc agctcccgca ccccgaccta gttctggccc tataaaaacc tgctatagtc   3120

tgtaagcagg gctgcctcct ctaactgtgg tggagcagcc aagcagctca ataaagcttg   3180

cttgcctg                                                            3188


<210>  2621
<211>  606
<212>  PRT
<213>  Homo sapiens

<400>  2621


Met Thr Leu Leu Thr Phe Arg Asp Val Ala Ile Glu Phe Ser Leu Glu 
1               5                   10                  15      


Glu Trp Lys Cys Leu Asp Leu Ala Gln Gln Asn Leu Tyr Arg Asp Val 
            20                  25                  30          


Met Leu Glu Asn Tyr Arg Asn Leu Phe Ser Val Gly Leu Thr Val Cys 
        35                  40                  45              


Lys Pro Gly Leu Ile Thr Cys Leu Glu Gln Arg Lys Glu Pro Trp Asn 
    50                  55                  60                  


Val Lys Arg Gln Glu Ala Ala Asp Gly His Pro Glu Met Gly Phe His 
65                  70                  75                  80  


His Ala Thr Gln Ala Cys Leu Glu Leu Leu Gly Ser Ser Asp Leu Pro 
                85                  90                  95      


Ala Ser Ala Ser Gln Ser Ala Gly Ile Thr Gly Val Asn His Arg Ala 
            100                 105                 110         


Gln Pro Gly Leu Asn Val Ser Val Asp Lys Phe Thr Ala Met Ser Ser 
        115                 120                 125             


His Phe Thr Gln Asp Leu Leu Pro Glu Gln Gly Ile Gln Asp Ala Phe 
    130                 135                 140                 


Pro Lys Arg Ile Leu Arg Gly Tyr Gly Asn Cys Gly Leu Asp Asn Leu 
145                 150                 155                 160 


Tyr Leu Arg Lys Asp Trp Glu Ser Leu Asp Glu Cys Lys Leu Gln Lys 
                165                 170                 175     


Asp Tyr Asn Gly Leu Asn Gln Cys Ser Ser Thr Thr His Ser Lys Ile 
            180                 185                 190         


Phe Gln Tyr Asn Lys Tyr Val Lys Ile Phe Asp Asn Phe Ser Asn Leu 
        195                 200                 205             


His Arg Arg Asn Ile Ser Asn Thr Gly Glu Lys Pro Phe Lys Cys Gln 
    210                 215                 220                 


Glu Cys Gly Lys Ser Phe Gln Met Leu Ser Phe Leu Thr Glu His Gln 
225                 230                 235                 240 


Lys Ile His Thr Gly Lys Lys Phe Gln Lys Cys Gly Glu Cys Gly Lys 
                245                 250                 255     


Thr Phe Ile Gln Cys Ser His Phe Thr Glu Pro Glu Asn Ile Asp Thr 
            260                 265                 270         


Gly Glu Lys Pro Tyr Lys Cys Gln Glu Cys Asn Asn Val Ile Lys Thr 
        275                 280                 285             


Cys Ser Val Leu Thr Lys Asn Arg Ile Tyr Ala Gly Gly Glu His Tyr 
    290                 295                 300                 


Arg Cys Glu Glu Phe Gly Lys Val Phe Asn Gln Cys Ser His Leu Thr 
305                 310                 315                 320 


Glu His Glu His Gly Thr Glu Glu Lys Pro Cys Lys Tyr Glu Glu Cys 
                325                 330                 335     


Ser Ser Val Phe Ile Ser Cys Ser Ser Leu Ser Asn Gln Gln Met Ile 
            340                 345                 350         


Leu Ala Gly Glu Lys Leu Ser Lys Cys Glu Thr Trp Tyr Lys Gly Phe 
        355                 360                 365             


Asn His Ser Pro Asn Pro Ser Lys His Gln Arg Asn Glu Ile Gly Gly 
    370                 375                 380                 


Lys Pro Phe Lys Cys Glu Glu Cys Asp Ser Ile Phe Lys Trp Phe Ser 
385                 390                 395                 400 


Asp Leu Thr Lys His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys 
                405                 410                 415     


Cys Asp Glu Cys Gly Lys Ala Tyr Thr Gln Ser Ser His Leu Ser Glu 
            420                 425                 430         


His Arg Arg Ile His Thr Gly Glu Lys Pro Tyr Gln Cys Glu Glu Cys 
        435                 440                 445             


Gly Lys Val Phe Arg Thr Cys Ser Ser Leu Ser Asn His Lys Arg Thr 
    450                 455                 460                 


His Ser Glu Glu Lys Pro Tyr Thr Cys Glu Glu Cys Gly Asn Ile Phe 
465                 470                 475                 480 


Lys Gln Leu Ser Asp Leu Thr Lys His Lys Lys Thr His Thr Gly Glu 
                485                 490                 495     


Lys Pro Tyr Lys Cys Asp Glu Cys Gly Lys Asn Phe Thr Gln Ser Ser 
            500                 505                 510         


Asn Leu Ile Val His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys 
        515                 520                 525             


Cys Glu Glu Cys Gly Arg Val Phe Met Trp Phe Ser Asp Ile Thr Lys 
    530                 535                 540                 


His Lys Lys Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys 
545                 550                 555                 560 


Gly Lys Asn Phe Thr Gln Ser Ser Asn Leu Ile Val His Lys Arg Ile 
                565                 570                 575     


His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Lys Cys Gly Lys Ala Phe 
            580                 585                 590         


Thr Gln Phe Ser His Leu Thr Val His Glu Ser Ile His Thr 
        595                 600                 605     

<210>  2622
<211>  3339
<212>  DNA
<213>  Homo sapiens

<400>  2622
aatcaggcac atgtctggag aggagaggac ggcttccggg atctagcggg gcctttgtcc     60

cgacagagct ccacttcctg tccccgcggc tctgtgtccc ctgctagccg taggtcgtgt    120

gacccgcagg caccgggaga tccagaagtg aaacgccagg ctctctggag gccaggagat    180

ggtgtgattt gtccagagaa tctttcctaa gaggaaatcc cagagaagca ggagaaagag    240

aaagaaatgg ctggtgctca gactctgttg acgttcaggg atgtggccat agaattctcc    300

ctggaggagt ggaaatgcct ggacctcgct cagcagaatt tgtacaggga tgtgatgttg    360

gagaactaca gaaacttgtt ctccgttggt ctcactgtct gtaagccagg cctgatcacc    420

tgcctggagc aacgaaaaga gccctggaat gtgaagagac aggaggcagc agacggacat    480

ccaggtattt tctttgtggt taccatggaa attatataaa acatcttaaa gttacaacaa    540

ggtattttac actgagatgg gatttcacca tgctactcag gcttgtcttg aactcctggg    600

ctcaagcgat ctgcctgcct cagcctccca aagtgctggg attacaggtg tgaaccaccg    660

tgcccagcca ggcctcaatg tttctgtgga caaattcact gctatgtctt ctcattttac    720

ccaagacctt ctgccagagc agggcataca agatgcattc ccaaaaagaa tactgagagg    780

atatggaaat tgtggccttg ataatttata tttaaggaaa gactgggaaa gtttagatga    840

gtgtaagttg caaaaagatt ataatggact taaccaatgt tcatcaacta cccatagcaa    900

aatctttcaa tataataaat atgttaaaat ctttgataac ttttcaaatt tacatagacg    960

taatataagt aatactggag agaaaccttt caaatgtcaa gaatgtggca aatcctttca   1020

aatgctctca ttcctaactg aacatcagaa aattcacact ggaaaaaaat tccaaaaatg   1080

tggagaatgt ggcaaaacct ttatccagtg ctcacacttt actgaacctg agaacattga   1140

cactggagag aaaccttaca agtgtcaaga atgtaacaac gtcattaaaa cttgctcagt   1200

ccttactaaa aatagaattt atgccggagg ggaacattac agatgtgaag aatttggcaa   1260

agtatttaac cagtgctccc accttactga acatgagcat ggtactgagg aaaaaccctg   1320

caaatatgaa gagtgcagca gtgtctttat ctcttgctca agcctttcta atcaacagat   1380

gattcttgct ggagagaagc tctccaaatg tgaaacatgg tacaaaggtt ttaaccacag   1440

cccaaatcct tccaaacacc agagaaatga gattggaggg aaacctttca aatgtgagga   1500

atgtgacagc atcttcaagt ggttctcaga ccttactaaa cataagagaa ttcacactgg   1560

tgagaaacca tacaaatgtg acgaatgtgg gaaagcctat acacagtcct cacacctcag   1620

tgaacacagg aggattcaca ccggagagaa accctaccaa tgtgaagaat gtgggaaggt   1680

cttcagaact tgctcaagcc tttctaacca taagagaact cattctgaag aaaaacccta   1740

cacgtgtgaa gaatgtggca acatctttaa gcagttatca gacctcacta agcataagaa   1800

aacccatact ggagagaagc cctacaaatg tgacgaatgt ggaaaaaact ttacccagtc   1860

ctccaacctt attgtacata agagaattca tactggagag aaaccctaca agtgtgaaga   1920

atgtggcaga gtcttcatgt ggttctcaga cattaccaaa cataagaaaa cccatactgg   1980

agagaaaccc tacaaatgtg acgaatgtgg aaaaaacttt acccagtcct caaaccttat   2040

tgtacataag agaattcata ctggagagaa accctacaag tgtgaaaagt gtggcaaagc   2100

cttcacccag ttctcacacc tgactgtaca tgaaagcatt catacttgag aaaaaaataa   2160

acaaatataa aaataggcaa agccgttagt atctgctcgc atcccacttt acatcagagt   2220

tcagacttaa taaagttatc ataaatgtaa ttactattga aagacctttc atgaaatata   2280

agtctccaga gcacacaaga gtatttcttc tgaaaaaaat gttacaatta tactagatgg   2340

aagacttgca tcagttgctt aaactttcag aaaatttgta gagaaaccca acaaatctca   2400

taaatgtgga ataacatttg ttcaaaaatg atagcttaga aaacactaga gttcatacta   2460

aaagatattt tgcaaataca ctaaatggga aaaataagca aggacacgtt cagaaatgac   2520

actgaatccc tgtgttgagt ctacagagac atctagactt aaaatagatc atttatattt   2580

aagtttaaaa ggaggatgag actgagtttt tgtagagtta taattacatt caaaatatac   2640

ttttttgcat tgaaaaaatg ttaaattttt gaaaagcgaa tattgatgtc attctattct   2700

caaatcagta gatgctgtgt cttcatttct agtgctgatg tgaaaacaca tggtcagttg   2760

ttgctgcgtc agagatatga gaaattcttt tctcttaggt gtgcatcact gatatacttg   2820

tccgtgaaag gtgaaagaca ctgaaatgta agatgcgtga gtaaaatctt ggtagagagg   2880

ctctttgtgg ttgttttata tacttgtaag tgatttatga gataggtgtt tagaataata   2940

ctcttctgtt agggtcaccc tgatcagacc gttcccttcc cctcccacag gacttacaat   3000

acggtccctt gtgctctctg cacagctacc ccagggcaaa aaacaaaccc cccttcactg   3060

atccctccag taactgtgca gacagttaca ggatgcggtt aacatgtctg ttcacctcgc   3120

ataacaaagc tggcaaaaaa catctccagg atgcagacaa gacacctgca ccctcgacta   3180

agctccccca ccccaaccca gttctcctgc acccccaact cagctcccgc accccgacct   3240

agttctggcc ctataaaaac ctgctatagt ctgtaagcag ggctgcctcc tctaactgtg   3300

gtggagcagc caagcagctc aataaagctt gcttgcctg                          3339


<210>  2623
<211>  530
<212>  PRT
<213>  Homo sapiens

<400>  2623


Met Gly Phe His His Ala Thr Gln Ala Cys Leu Glu Leu Leu Gly Ser 
1               5                   10                  15      


Ser Asp Leu Pro Ala Ser Ala Ser Gln Ser Ala Gly Ile Thr Gly Val 
            20                  25                  30          


Asn His Arg Ala Gln Pro Gly Leu Asn Val Ser Val Asp Lys Phe Thr 
        35                  40                  45              


Ala Met Ser Ser His Phe Thr Gln Asp Leu Leu Pro Glu Gln Gly Ile 
    50                  55                  60                  


Gln Asp Ala Phe Pro Lys Arg Ile Leu Arg Gly Tyr Gly Asn Cys Gly 
65                  70                  75                  80  


Leu Asp Asn Leu Tyr Leu Arg Lys Asp Trp Glu Ser Leu Asp Glu Cys 
                85                  90                  95      


Lys Leu Gln Lys Asp Tyr Asn Gly Leu Asn Gln Cys Ser Ser Thr Thr 
            100                 105                 110         


His Ser Lys Ile Phe Gln Tyr Asn Lys Tyr Val Lys Ile Phe Asp Asn 
        115                 120                 125             


Phe Ser Asn Leu His Arg Arg Asn Ile Ser Asn Thr Gly Glu Lys Pro 
    130                 135                 140                 


Phe Lys Cys Gln Glu Cys Gly Lys Ser Phe Gln Met Leu Ser Phe Leu 
145                 150                 155                 160 


Thr Glu His Gln Lys Ile His Thr Gly Lys Lys Phe Gln Lys Cys Gly 
                165                 170                 175     


Glu Cys Gly Lys Thr Phe Ile Gln Cys Ser His Phe Thr Glu Pro Glu 
            180                 185                 190         


Asn Ile Asp Thr Gly Glu Lys Pro Tyr Lys Cys Gln Glu Cys Asn Asn 
        195                 200                 205             


Val Ile Lys Thr Cys Ser Val Leu Thr Lys Asn Arg Ile Tyr Ala Gly 
    210                 215                 220                 


Gly Glu His Tyr Arg Cys Glu Glu Phe Gly Lys Val Phe Asn Gln Cys 
225                 230                 235                 240 


Ser His Leu Thr Glu His Glu His Gly Thr Glu Glu Lys Pro Cys Lys 
                245                 250                 255     


Tyr Glu Glu Cys Ser Ser Val Phe Ile Ser Cys Ser Ser Leu Ser Asn 
            260                 265                 270         


Gln Gln Met Ile Leu Ala Gly Glu Lys Leu Ser Lys Cys Glu Thr Trp 
        275                 280                 285             


Tyr Lys Gly Phe Asn His Ser Pro Asn Pro Ser Lys His Gln Arg Asn 
    290                 295                 300                 


Glu Ile Gly Gly Lys Pro Phe Lys Cys Glu Glu Cys Asp Ser Ile Phe 
305                 310                 315                 320 


Lys Trp Phe Ser Asp Leu Thr Lys His Lys Arg Ile His Thr Gly Glu 
                325                 330                 335     


Lys Pro Tyr Lys Cys Asp Glu Cys Gly Lys Ala Tyr Thr Gln Ser Ser 
            340                 345                 350         


His Leu Ser Glu His Arg Arg Ile His Thr Gly Glu Lys Pro Tyr Gln 
        355                 360                 365             


Cys Glu Glu Cys Gly Lys Val Phe Arg Thr Cys Ser Ser Leu Ser Asn 
    370                 375                 380                 


His Lys Arg Thr His Ser Glu Glu Lys Pro Tyr Thr Cys Glu Glu Cys 
385                 390                 395                 400 


Gly Asn Ile Phe Lys Gln Leu Ser Asp Leu Thr Lys His Lys Lys Thr 
                405                 410                 415     


His Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly Lys Asn Phe 
            420                 425                 430         


Thr Gln Ser Ser Asn Leu Ile Val His Lys Arg Ile His Thr Gly Glu 
        435                 440                 445             


Lys Pro Tyr Lys Cys Glu Glu Cys Gly Arg Val Phe Met Trp Phe Ser 
    450                 455                 460                 


Asp Ile Thr Lys His Lys Lys Thr His Thr Gly Glu Lys Pro Tyr Lys 
465                 470                 475                 480 


Cys Asp Glu Cys Gly Lys Asn Phe Thr Gln Ser Ser Asn Leu Ile Val 
                485                 490                 495     


His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Lys Cys 
            500                 505                 510         


Gly Lys Ala Phe Thr Gln Phe Ser His Leu Thr Val His Glu Ser Ile 
        515                 520                 525             


His Thr 
    530 

<210>  2624
<211>  3622
<212>  DNA
<213>  Homo sapiens

<400>  2624
aatcaggcac atgtctggag aggagaggac ggcttccggg atctagcggg gcctttgtcc     60

cgacagagct ccacttcctg tccccgcggc tctgtgtccc ctgctagccg taggtcgtgt    120

gacccgcagg caccgggaga tccagaagtg aaacgccagg ctctctggag gccaggagat    180

ggcacagaca ccttaccaga atgtctttgg tttgaggttc cactttggaa acttgacagg    240

gtgatttgct ctcagccacc ctctggactt tttcctcagt ttcagtattg tccagggata    300

acacaggatg cccaccatgg ccatgtctgc tggagcatct agtgaatttc aggccctggg    360

ttatttctca gaggacagcc tgaggtatga agtgtggcct ctccagggag cagctggatg    420

ccctgggctg agagaaatct cctggtctac tcttcctcta aagaggtgtg atttgtccag    480

agaatctttc ctaagaggaa atcccagaga agcaggagaa agagaaagaa atggctggtg    540

ctcagactct gttgacgttc agggatgtgg ccatagaatt ctccctggag gagtggaaat    600

gcctggacct cgctcagcag aatttgtaca gggatgtgat gttggagaac tacagaaact    660

tgttctccgt tggtctcact gtctgtaagc caggcctgat cacctgcctg gagcaacgaa    720

aagagccctg gaatgtgaag agacaggagg cagcagacgg acatccagag atgggatttc    780

accatgctac tcaggcttgt cttgaactcc tgggctcaag cgatctgcct gcctcagcct    840

cccaaagtgc tgggattaca ggtgtgaacc accgtgccca gccaggcctc aatgtttctg    900

tggacaaatt cactgcactg tgctcacctg gggtgctgca aactgtgaaa tggtttttag    960

agttcagatg catcttctca ctagctatgt cttctcattt tacccaagac cttctgccag   1020

agcagggcat acaagatgca ttcccaaaaa gaatactgag aggatatgga aattgtggcc   1080

ttgataattt atatttaagg aaagactggg aaagtttaga tgagtgtaag ttgcaaaaag   1140

attataatgg acttaaccaa tgttcatcaa ctacccatag caaaatcttt caatataata   1200

aatatgttaa aatctttgat aacttttcaa atttacatag acgtaatata agtaatactg   1260

gagagaaacc tttcaaatgt caagaatgtg gcaaatcctt tcaaatgctc tcattcctaa   1320

ctgaacatca gaaaattcac actggaaaaa aattccaaaa atgtggagaa tgtggcaaaa   1380

cctttatcca gtgctcacac tttactgaac ctgagaacat tgacactgga gagaaacctt   1440

acaagtgtca agaatgtaac aacgtcatta aaacttgctc agtccttact aaaaatagaa   1500

tttatgccgg aggggaacat tacagatgtg aagaatttgg caaagtattt aaccagtgct   1560

cccaccttac tgaacatgag catggtactg aggaaaaacc ctgcaaatat gaagagtgca   1620

gcagtgtctt tatctcttgc tcaagccttt ctaatcaaca gatgattctt gctggagaga   1680

agctctccaa atgtgaaaca tggtacaaag gttttaacca cagcccaaat ccttccaaac   1740

accagagaaa tgagattgga gggaaacctt tcaaatgtga ggaatgtgac agcatcttca   1800

agtggttctc agaccttact aaacataaga gaattcacac tggtgagaaa ccatacaaat   1860

gtgacgaatg tgggaaagcc tatacacagt cctcacacct cagtgaacac aggaggattc   1920

acaccggaga gaaaccctac caatgtgaag aatgtgggaa ggtcttcaga acttgctcaa   1980

gcctttctaa ccataagaga actcattctg aagaaaaacc ctacacgtgt gaagaatgtg   2040

gcaacatctt taagcagtta tcagacctca ctaagcataa gaaaacccat actggagaga   2100

agccctacaa atgtgacgaa tgtggaaaaa actttaccca gtcctccaac cttattgtac   2160

ataagagaat tcatactgga gagaaaccct acaagtgtga agaatgtggc agagtcttca   2220

tgtggttctc agacattacc aaacataaga aaacccatac tggagagaaa ccctacaaat   2280

gtgacgaatg tggaaaaaac tttacccagt cctcaaacct tattgtacat aagagaattc   2340

atactggaga gaaaccctac aagtgtgaaa agtgtggcaa agccttcacc cagttctcac   2400

acctgactgt acatgaaagc attcatactt gagaaaaaaa taaacaaata taaaaatagg   2460

caaagccgtt agtatctgct cgcatcccac tttacatcag agttcagact taataaagtt   2520

atcataaatg taattactat tgaaagacct ttcatgaaat ataagtctcc agagcacaca   2580

agagtatttc ttctgaaaaa aatgttacaa ttatactaga tggaagactt gcatcagttg   2640

cttaaacttt cagaaaattt gtagagaaac ccaacaaatc tcataaatgt ggaataacat   2700

ttgttcaaaa atgatagctt agaaaacact agagttcata ctaaaagata ttttgcaaat   2760

acactaaatg ggaaaaataa gcaaggacac gttcagaaat gacactgaat ccctgtgttg   2820

agtctacaga gacatctaga cttaaaatag atcatttata tttaagttta aaaggaggat   2880

gagactgagt ttttgtagag ttataattac attcaaaata tacttttttg cattgaaaaa   2940

atgttaaatt tttgaaaagc gaatattgat gtcattctat tctcaaatca gtagatgctg   3000

tgtcttcatt tctagtgctg atgtgaaaac acatggtcag ttgttgctgc gtcagagata   3060

tgagaaattc ttttctctta ggtgtgcatc actgatatac ttgtccgtga aaggtgaaag   3120

acactgaaat gtaagatgcg tgagtaaaat cttggtagag aggctctttg tggttgtttt   3180

atatacttgt aagtgattta tgagataggt gtttagaata atactcttct gttagggtca   3240

ccctgatcag accgttccct tcccctccca caggacttac aatacggtcc cttgtgctct   3300

ctgcacagct accccagggc aaaaaacaaa ccccccttca ctgatccctc cagtaactgt   3360

gcagacagtt acaggatgcg gttaacatgt ctgttcacct cgcataacaa agctggcaaa   3420

aaacatctcc aggatgcaga caagacacct gcaccctcga ctaagctccc ccaccccaac   3480

ccagttctcc tgcaccccca actcagctcc cgcaccccga cctagttctg gccctataaa   3540

aacctgctat agtctgtaag cagggctgcc tcctctaact gtggtggagc agccaagcag   3600

ctcaataaag cttgcttgcc tg                                            3622


<210>  2625
<211>  633
<212>  PRT
<213>  Homo sapiens

<400>  2625


Met Ala Gly Ala Gln Thr Leu Leu Thr Phe Arg Asp Val Ala Ile Glu 
1               5                   10                  15      


Phe Ser Leu Glu Glu Trp Lys Cys Leu Asp Leu Ala Gln Gln Asn Leu 
            20                  25                  30          


Tyr Arg Asp Val Met Leu Glu Asn Tyr Arg Asn Leu Phe Ser Val Gly 
        35                  40                  45              


Leu Thr Val Cys Lys Pro Gly Leu Ile Thr Cys Leu Glu Gln Arg Lys 
    50                  55                  60                  


Glu Pro Trp Asn Val Lys Arg Gln Glu Ala Ala Asp Gly His Pro Glu 
65                  70                  75                  80  


Met Gly Phe His His Ala Thr Gln Ala Cys Leu Glu Leu Leu Gly Ser 
                85                  90                  95      


Ser Asp Leu Pro Ala Ser Ala Ser Gln Ser Ala Gly Ile Thr Gly Val 
            100                 105                 110         


Asn His Arg Ala Gln Pro Gly Leu Asn Val Ser Val Asp Lys Phe Thr 
        115                 120                 125             


Ala Leu Cys Ser Pro Gly Val Leu Gln Thr Val Lys Trp Phe Leu Glu 
    130                 135                 140                 


Phe Arg Cys Ile Phe Ser Leu Ala Met Ser Ser His Phe Thr Gln Asp 
145                 150                 155                 160 


Leu Leu Pro Glu Gln Gly Ile Gln Asp Ala Phe Pro Lys Arg Ile Leu 
                165                 170                 175     


Arg Gly Tyr Gly Asn Cys Gly Leu Asp Asn Leu Tyr Leu Arg Lys Asp 
            180                 185                 190         


Trp Glu Ser Leu Asp Glu Cys Lys Leu Gln Lys Asp Tyr Asn Gly Leu 
        195                 200                 205             


Asn Gln Cys Ser Ser Thr Thr His Ser Lys Ile Phe Gln Tyr Asn Lys 
    210                 215                 220                 


Tyr Val Lys Ile Phe Asp Asn Phe Ser Asn Leu His Arg Arg Asn Ile 
225                 230                 235                 240 


Ser Asn Thr Gly Glu Lys Pro Phe Lys Cys Gln Glu Cys Gly Lys Ser 
                245                 250                 255     


Phe Gln Met Leu Ser Phe Leu Thr Glu His Gln Lys Ile His Thr Gly 
            260                 265                 270         


Lys Lys Phe Gln Lys Cys Gly Glu Cys Gly Lys Thr Phe Ile Gln Cys 
        275                 280                 285             


Ser His Phe Thr Glu Pro Glu Asn Ile Asp Thr Gly Glu Lys Pro Tyr 
    290                 295                 300                 


Lys Cys Gln Glu Cys Asn Asn Val Ile Lys Thr Cys Ser Val Leu Thr 
305                 310                 315                 320 


Lys Asn Arg Ile Tyr Ala Gly Gly Glu His Tyr Arg Cys Glu Glu Phe 
                325                 330                 335     


Gly Lys Val Phe Asn Gln Cys Ser His Leu Thr Glu His Glu His Gly 
            340                 345                 350         


Thr Glu Glu Lys Pro Cys Lys Tyr Glu Glu Cys Ser Ser Val Phe Ile 
        355                 360                 365             


Ser Cys Ser Ser Leu Ser Asn Gln Gln Met Ile Leu Ala Gly Glu Lys 
    370                 375                 380                 


Leu Ser Lys Cys Glu Thr Trp Tyr Lys Gly Phe Asn His Ser Pro Asn 
385                 390                 395                 400 


Pro Ser Lys His Gln Arg Asn Glu Ile Gly Gly Lys Pro Phe Lys Cys 
                405                 410                 415     


Glu Glu Cys Asp Ser Ile Phe Lys Trp Phe Ser Asp Leu Thr Lys His 
            420                 425                 430         


Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly 
        435                 440                 445             


Lys Ala Tyr Thr Gln Ser Ser His Leu Ser Glu His Arg Arg Ile His 
    450                 455                 460                 


Thr Gly Glu Lys Pro Tyr Gln Cys Glu Glu Cys Gly Lys Val Phe Arg 
465                 470                 475                 480 


Thr Cys Ser Ser Leu Ser Asn His Lys Arg Thr His Ser Glu Glu Lys 
                485                 490                 495     


Pro Tyr Thr Cys Glu Glu Cys Gly Asn Ile Phe Lys Gln Leu Ser Asp 
            500                 505                 510         


Leu Thr Lys His Lys Lys Thr His Thr Gly Glu Lys Pro Tyr Lys Cys 
        515                 520                 525             


Asp Glu Cys Gly Lys Asn Phe Thr Gln Ser Ser Asn Leu Ile Val His 
    530                 535                 540                 


Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly 
545                 550                 555                 560 


Arg Val Phe Met Trp Phe Ser Asp Ile Thr Lys His Lys Lys Thr His 
                565                 570                 575     


Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly Lys Asn Phe Thr 
            580                 585                 590         


Gln Ser Ser Asn Leu Ile Val His Lys Arg Ile His Thr Gly Glu Lys 
        595                 600                 605             


Pro Tyr Lys Cys Glu Lys Cys Gly Lys Ala Phe Thr Gln Phe Ser His 
    610                 615                 620                 


Leu Thr Val His Glu Ser Ile His Thr 
625                 630             

<210>  2626
<211>  3338
<212>  DNA
<213>  Homo sapiens

<400>  2626
aatcaggcac atgtctggag aggagaggac ggcttccggg atctagcggg gcctttgtcc     60

cgacagagct ccacttcctg tccccgcggc tctgtgtccc ctgctagccg taggtcgtgt    120

gacccgcagg caccgggaga tccagaagtg aaacgccagg ctctctggag gccaggagat    180

ggtgtgattt gtccagagaa tctttcctaa gaggaaatcc cagagaagca ggagaaagag    240

aaagaaatgg ctggtgctca gactctgttg acgttcaggg atgtggccat agaattctcc    300

ctggaggagt ggaaatgcct ggacctcgct cagcagaatt tgtacaggga tgtgatgttg    360

gagaactaca gaaacttgtt ctccgttggt ctcactgtct gtaagccagg cctgatcacc    420

tgcctggagc aacgaaaaga gccctggaat gtgaagagac aggaggcagc agacggacat    480

ccagagatgg gatttcacca tgctactcag gcttgtcttg aactcctggg ctcaagcgat    540

ctgcctgcct cagcctccca aagtgctggg attacaggtg tgaaccaccg tgcccagcca    600

ggcctcaatg tttctgtgga caaattcact gcactgtgct cacctggggt gctgcaaact    660

gtgaaatggt ttttagagtt cagatgcatc ttctcactag ctatgtcttc tcattttacc    720

caagaccttc tgccagagca gggcatacaa gatgcattcc caaaaagaat actgagagga    780

tatggaaatt gtggccttga taatttatat ttaaggaaag actgggaaag tttagatgag    840

tgtaagttgc aaaaagatta taatggactt aaccaatgtt catcaactac ccatagcaaa    900

atctttcaat ataataaata tgttaaaatc tttgataact tttcaaattt acatagacgt    960

aatataagta atactggaga gaaacctttc aaatgtcaag aatgtggcaa atcctttcaa   1020

atgctctcat tcctaactga acatcagaaa attcacactg gaaaaaaatt ccaaaaatgt   1080

ggagaatgtg gcaaaacctt tatccagtgc tcacacttta ctgaacctga gaacattgac   1140

actggagaga aaccttacaa gtgtcaagaa tgtaacaacg tcattaaaac ttgctcagtc   1200

cttactaaaa atagaattta tgccggaggg gaacattaca gatgtgaaga atttggcaaa   1260

gtatttaacc agtgctccca ccttactgaa catgagcatg gtactgagga aaaaccctgc   1320

aaatatgaag agtgcagcag tgtctttatc tcttgctcaa gcctttctaa tcaacagatg   1380

attcttgctg gagagaagct ctccaaatgt gaaacatggt acaaaggttt taaccacagc   1440

ccaaatcctt ccaaacacca gagaaatgag attggaggga aacctttcaa atgtgaggaa   1500

tgtgacagca tcttcaagtg gttctcagac cttactaaac ataagagaat tcacactggt   1560

gagaaaccat acaaatgtga cgaatgtggg aaagcctata cacagtcctc acacctcagt   1620

gaacacagga ggattcacac cggagagaaa ccctaccaat gtgaagaatg tgggaaggtc   1680

ttcagaactt gctcaagcct ttctaaccat aagagaactc attctgaaga aaaaccctac   1740

acgtgtgaag aatgtggcaa catctttaag cagttatcag acctcactaa gcataagaaa   1800

acccatactg gagagaagcc ctacaaatgt gacgaatgtg gaaaaaactt tacccagtcc   1860

tccaacctta ttgtacataa gagaattcat actggagaga aaccctacaa gtgtgaagaa   1920

tgtggcagag tcttcatgtg gttctcagac attaccaaac ataagaaaac ccatactgga   1980

gagaaaccct acaaatgtga cgaatgtgga aaaaacttta cccagtcctc aaaccttatt   2040

gtacataaga gaattcatac tggagagaaa ccctacaagt gtgaaaagtg tggcaaagcc   2100

ttcacccagt tctcacacct gactgtacat gaaagcattc atacttgaga aaaaaataaa   2160

caaatataaa aataggcaaa gccgttagta tctgctcgca tcccacttta catcagagtt   2220

cagacttaat aaagttatca taaatgtaat tactattgaa agacctttca tgaaatataa   2280

gtctccagag cacacaagag tatttcttct gaaaaaaatg ttacaattat actagatgga   2340

agacttgcat cagttgctta aactttcaga aaatttgtag agaaacccaa caaatctcat   2400

aaatgtggaa taacatttgt tcaaaaatga tagcttagaa aacactagag ttcatactaa   2460

aagatatttt gcaaatacac taaatgggaa aaataagcaa ggacacgttc agaaatgaca   2520

ctgaatccct gtgttgagtc tacagagaca tctagactta aaatagatca tttatattta   2580

agtttaaaag gaggatgaga ctgagttttt gtagagttat aattacattc aaaatatact   2640

tttttgcatt gaaaaaatgt taaatttttg aaaagcgaat attgatgtca ttctattctc   2700

aaatcagtag atgctgtgtc ttcatttcta gtgctgatgt gaaaacacat ggtcagttgt   2760

tgctgcgtca gagatatgag aaattctttt ctcttaggtg tgcatcactg atatacttgt   2820

ccgtgaaagg tgaaagacac tgaaatgtaa gatgcgtgag taaaatcttg gtagagaggc   2880

tctttgtggt tgttttatat acttgtaagt gatttatgag ataggtgttt agaataatac   2940

tcttctgtta gggtcaccct gatcagaccg ttcccttccc ctcccacagg acttacaata   3000

cggtcccttg tgctctctgc acagctaccc cagggcaaaa aacaaacccc ccttcactga   3060

tccctccagt aactgtgcag acagttacag gatgcggtta acatgtctgt tcacctcgca   3120

taacaaagct ggcaaaaaac atctccagga tgcagacaag acacctgcac cctcgactaa   3180

gctcccccac cccaacccag ttctcctgca cccccaactc agctcccgca ccccgaccta   3240

gttctggccc tataaaaacc tgctatagtc tgtaagcagg gctgcctcct ctaactgtgg   3300

tggagcagcc aagcagctca ataaagcttg cttgcctg                           3338


<210>  2627
<211>  633
<212>  PRT
<213>  Homo sapiens

<400>  2627


Met Ala Gly Ala Gln Thr Leu Leu Thr Phe Arg Asp Val Ala Ile Glu 
1               5                   10                  15      


Phe Ser Leu Glu Glu Trp Lys Cys Leu Asp Leu Ala Gln Gln Asn Leu 
            20                  25                  30          


Tyr Arg Asp Val Met Leu Glu Asn Tyr Arg Asn Leu Phe Ser Val Gly 
        35                  40                  45              


Leu Thr Val Cys Lys Pro Gly Leu Ile Thr Cys Leu Glu Gln Arg Lys 
    50                  55                  60                  


Glu Pro Trp Asn Val Lys Arg Gln Glu Ala Ala Asp Gly His Pro Glu 
65                  70                  75                  80  


Met Gly Phe His His Ala Thr Gln Ala Cys Leu Glu Leu Leu Gly Ser 
                85                  90                  95      


Ser Asp Leu Pro Ala Ser Ala Ser Gln Ser Ala Gly Ile Thr Gly Val 
            100                 105                 110         


Asn His Arg Ala Gln Pro Gly Leu Asn Val Ser Val Asp Lys Phe Thr 
        115                 120                 125             


Ala Leu Cys Ser Pro Gly Val Leu Gln Thr Val Lys Trp Phe Leu Glu 
    130                 135                 140                 


Phe Arg Cys Ile Phe Ser Leu Ala Met Ser Ser His Phe Thr Gln Asp 
145                 150                 155                 160 


Leu Leu Pro Glu Gln Gly Ile Gln Asp Ala Phe Pro Lys Arg Ile Leu 
                165                 170                 175     


Arg Gly Tyr Gly Asn Cys Gly Leu Asp Asn Leu Tyr Leu Arg Lys Asp 
            180                 185                 190         


Trp Glu Ser Leu Asp Glu Cys Lys Leu Gln Lys Asp Tyr Asn Gly Leu 
        195                 200                 205             


Asn Gln Cys Ser Ser Thr Thr His Ser Lys Ile Phe Gln Tyr Asn Lys 
    210                 215                 220                 


Tyr Val Lys Ile Phe Asp Asn Phe Ser Asn Leu His Arg Arg Asn Ile 
225                 230                 235                 240 


Ser Asn Thr Gly Glu Lys Pro Phe Lys Cys Gln Glu Cys Gly Lys Ser 
                245                 250                 255     


Phe Gln Met Leu Ser Phe Leu Thr Glu His Gln Lys Ile His Thr Gly 
            260                 265                 270         


Lys Lys Phe Gln Lys Cys Gly Glu Cys Gly Lys Thr Phe Ile Gln Cys 
        275                 280                 285             


Ser His Phe Thr Glu Pro Glu Asn Ile Asp Thr Gly Glu Lys Pro Tyr 
    290                 295                 300                 


Lys Cys Gln Glu Cys Asn Asn Val Ile Lys Thr Cys Ser Val Leu Thr 
305                 310                 315                 320 


Lys Asn Arg Ile Tyr Ala Gly Gly Glu His Tyr Arg Cys Glu Glu Phe 
                325                 330                 335     


Gly Lys Val Phe Asn Gln Cys Ser His Leu Thr Glu His Glu His Gly 
            340                 345                 350         


Thr Glu Glu Lys Pro Cys Lys Tyr Glu Glu Cys Ser Ser Val Phe Ile 
        355                 360                 365             


Ser Cys Ser Ser Leu Ser Asn Gln Gln Met Ile Leu Ala Gly Glu Lys 
    370                 375                 380                 


Leu Ser Lys Cys Glu Thr Trp Tyr Lys Gly Phe Asn His Ser Pro Asn 
385                 390                 395                 400 


Pro Ser Lys His Gln Arg Asn Glu Ile Gly Gly Lys Pro Phe Lys Cys 
                405                 410                 415     


Glu Glu Cys Asp Ser Ile Phe Lys Trp Phe Ser Asp Leu Thr Lys His 
            420                 425                 430         


Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly 
        435                 440                 445             


Lys Ala Tyr Thr Gln Ser Ser His Leu Ser Glu His Arg Arg Ile His 
    450                 455                 460                 


Thr Gly Glu Lys Pro Tyr Gln Cys Glu Glu Cys Gly Lys Val Phe Arg 
465                 470                 475                 480 


Thr Cys Ser Ser Leu Ser Asn His Lys Arg Thr His Ser Glu Glu Lys 
                485                 490                 495     


Pro Tyr Thr Cys Glu Glu Cys Gly Asn Ile Phe Lys Gln Leu Ser Asp 
            500                 505                 510         


Leu Thr Lys His Lys Lys Thr His Thr Gly Glu Lys Pro Tyr Lys Cys 
        515                 520                 525             


Asp Glu Cys Gly Lys Asn Phe Thr Gln Ser Ser Asn Leu Ile Val His 
    530                 535                 540                 


Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly 
545                 550                 555                 560 


Arg Val Phe Met Trp Phe Ser Asp Ile Thr Lys His Lys Lys Thr His 
                565                 570                 575     


Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly Lys Asn Phe Thr 
            580                 585                 590         


Gln Ser Ser Asn Leu Ile Val His Lys Arg Ile His Thr Gly Glu Lys 
        595                 600                 605             


Pro Tyr Lys Cys Glu Lys Cys Gly Lys Ala Phe Thr Gln Phe Ser His 
    610                 615                 620                 


Leu Thr Val His Glu Ser Ile His Thr 
625                 630             

<210>  2628
<211>  3238
<212>  DNA
<213>  Homo sapiens

<400>  2628
aatcaggcac atgtctggag aggagaggac ggcttccggg atctagcggg gcctttgtcc     60

cgacagagct ccacttcctg tccccgcggc tctgtgtccc ctgctagccg taggtcgtgt    120

gacccgcagg caccgggaga tccagaagtg aaacgccagg ctctctggag gccaggagat    180

ggcacagaca ccttaccaga atgtctttgg tttgaggttc cactttggaa acttgacagg    240

gtgatttgct ctcagccacc ctctggactt tttcctcagt ttcagtattg tccagggata    300

acacaggatg cccaccatgg ccatgtctgc tggagcatct agtgaatttc aggccctggg    360

ttatttctca gaggacagcc tgaggtatga agtgtggcct ctccagggag cagctggatg    420

ccctgggctg agagaaatct cctggtctac tcttcctcta aagaggtgtg atttgtccag    480

agaatctttc ctaagaggaa atcccagaga agcaggagaa agagaaagaa atggctggtg    540

ctcagactct gttgacgttc agggatgtgg ccatagaatt ctccctggag gagtggaaat    600

gcctggacct cgctcagcag aatttgtaca gggatgtgat gttggagaac tacagaaact    660

tgttctccgt tggtctcact gtctgtaagc caggcctgat cacctgcctg gagcaacgaa    720

aagagccctg gaatgtgaag agacaggagg cagcagacgg acatccagct atgtcttctc    780

attttaccca agaccttctg ccagagcagg gcatacaaga tgcattccca aaaagaatac    840

tgagaggata tggaaattgt ggccttgata atttatattt aaggaaagac tgggaaagtt    900

tagatgagtg taagttgcaa aaagattata atggacttaa ccaatgttca tcaactaccc    960

atagcaaaat ctttcaatat aataaatatg ttaaaatctt tgataacttt tcaaatttac   1020

atagacgtaa tataagtaat actggagaga aacctttcaa atgtcaagaa tgtggcaaat   1080

cctttcaaat gctctcattc ctaactgaac atcagaaaat tcacactgga aaaaaattcc   1140

aaaaatgtgg agaatgtggc aaaaccttta tccagtgctc acactttact gaacctgaga   1200

acattgacac tggagagaaa ccttacaagt gtcaagaatg taacaacgtc attaaaactt   1260

gctcagtcct tactaaaaat agaatttatg ccggagggga acattacaga tgtgaagaat   1320

ttggcaaagt atttaaccag tgctcccacc ttactgaaca tgagcatggt actgaggaaa   1380

aacctttcaa atgtgaggaa tgtgacagca tcttcaagtg gttctcagac cttactaaac   1440

ataagagaat tcacactggt gagaaaccat acaaatgtga cgaatgtggg aaagcctata   1500

cacagtcctc acacctcagt gaacacagga ggattcacac cggagagaaa ccctaccaat   1560

gtgaagaatg tgggaaggtc ttcagaactt gctcaagcct ttctaaccat aagagaactc   1620

attctgaaga aaaaccctac acgtgtgaag aatgtggcaa catctttaag cagttatcag   1680

acctcactaa gcataagaaa acccatactg gagagaagcc ctacaaatgt gacgaatgtg   1740

gaaaaaactt tacccagtcc tccaacctta ttgtacataa gagaattcat actggagaga   1800

aaccctacaa gtgtgaagaa tgtggcagag tcttcatgtg gttctcagac attaccaaac   1860

ataagaaaac ccatactgga gagaaaccct acaaatgtga cgaatgtgga aaaaacttta   1920

cccagtcctc aaaccttatt gtacataaga gaattcatac tggagagaaa ccctacaagt   1980

gtgaaaagtg tggcaaagcc ttcacccagt tctcacacct gactgtacat gaaagcattc   2040

atacttgaga aaaaaataaa caaatataaa aataggcaaa gccgttagta tctgctcgca   2100

tcccacttta catcagagtt cagacttaat aaagttatca taaatgtaat tactattgaa   2160

agacctttca tgaaatataa gtctccagag cacacaagag tatttcttct gaaaaaaatg   2220

ttacaattat actagatgga agacttgcat cagttgctta aactttcaga aaatttgtag   2280

agaaacccaa caaatctcat aaatgtggaa taacatttgt tcaaaaatga tagcttagaa   2340

aacactagag ttcatactaa aagatatttt gcaaatacac taaatgggaa aaataagcaa   2400

ggacacgttc agaaatgaca ctgaatccct gtgttgagtc tacagagaca tctagactta   2460

aaatagatca tttatattta agtttaaaag gaggatgaga ctgagttttt gtagagttat   2520

aattacattc aaaatatact tttttgcatt gaaaaaatgt taaatttttg aaaagcgaat   2580

attgatgtca ttctattctc aaatcagtag atgctgtgtc ttcatttcta gtgctgatgt   2640

gaaaacacat ggtcagttgt tgctgcgtca gagatatgag aaattctttt ctcttaggtg   2700

tgcatcactg atatacttgt ccgtgaaagg tgaaagacac tgaaatgtaa gatgcgtgag   2760

taaaatcttg gtagagaggc tctttgtggt tgttttatat acttgtaagt gatttatgag   2820

ataggtgttt agaataatac tcttctgtta gggtcaccct gatcagaccg ttcccttccc   2880

ctcccacagg acttacaata cggtcccttg tgctctctgc acagctaccc cagggcaaaa   2940

aacaaacccc ccttcactga tccctccagt aactgtgcag acagttacag gatgcggtta   3000

acatgtctgt tcacctcgca taacaaagct ggcaaaaaac atctccagga tgcagacaag   3060

acacctgcac cctcgactaa gctcccccac cccaacccag ttctcctgca cccccaactc   3120

agctcccgca ccccgaccta gttctggccc tataaaaacc tgctatagtc tgtaagcagg   3180

gctgcctcct ctaactgtgg tggagcagcc aagcagctca ataaagcttg cttgcctg     3238


<210>  2629
<211>  505
<212>  PRT
<213>  Homo sapiens

<400>  2629


Met Ala Gly Ala Gln Thr Leu Leu Thr Phe Arg Asp Val Ala Ile Glu 
1               5                   10                  15      


Phe Ser Leu Glu Glu Trp Lys Cys Leu Asp Leu Ala Gln Gln Asn Leu 
            20                  25                  30          


Tyr Arg Asp Val Met Leu Glu Asn Tyr Arg Asn Leu Phe Ser Val Gly 
        35                  40                  45              


Leu Thr Val Cys Lys Pro Gly Leu Ile Thr Cys Leu Glu Gln Arg Lys 
    50                  55                  60                  


Glu Pro Trp Asn Val Lys Arg Gln Glu Ala Ala Asp Gly His Pro Ala 
65                  70                  75                  80  


Met Ser Ser His Phe Thr Gln Asp Leu Leu Pro Glu Gln Gly Ile Gln 
                85                  90                  95      


Asp Ala Phe Pro Lys Arg Ile Leu Arg Gly Tyr Gly Asn Cys Gly Leu 
            100                 105                 110         


Asp Asn Leu Tyr Leu Arg Lys Asp Trp Glu Ser Leu Asp Glu Cys Lys 
        115                 120                 125             


Leu Gln Lys Asp Tyr Asn Gly Leu Asn Gln Cys Ser Ser Thr Thr His 
    130                 135                 140                 


Ser Lys Ile Phe Gln Tyr Asn Lys Tyr Val Lys Ile Phe Asp Asn Phe 
145                 150                 155                 160 


Ser Asn Leu His Arg Arg Asn Ile Ser Asn Thr Gly Glu Lys Pro Phe 
                165                 170                 175     


Lys Cys Gln Glu Cys Gly Lys Ser Phe Gln Met Leu Ser Phe Leu Thr 
            180                 185                 190         


Glu His Gln Lys Ile His Thr Gly Lys Lys Phe Gln Lys Cys Gly Glu 
        195                 200                 205             


Cys Gly Lys Thr Phe Ile Gln Cys Ser His Phe Thr Glu Pro Glu Asn 
    210                 215                 220                 


Ile Asp Thr Gly Glu Lys Pro Tyr Lys Cys Gln Glu Cys Asn Asn Val 
225                 230                 235                 240 


Ile Lys Thr Cys Ser Val Leu Thr Lys Asn Arg Ile Tyr Ala Gly Gly 
                245                 250                 255     


Glu His Tyr Arg Cys Glu Glu Phe Gly Lys Val Phe Asn Gln Cys Ser 
            260                 265                 270         


His Leu Thr Glu His Glu His Gly Thr Glu Glu Lys Pro Phe Lys Cys 
        275                 280                 285             


Glu Glu Cys Asp Ser Ile Phe Lys Trp Phe Ser Asp Leu Thr Lys His 
    290                 295                 300                 


Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly 
305                 310                 315                 320 


Lys Ala Tyr Thr Gln Ser Ser His Leu Ser Glu His Arg Arg Ile His 
                325                 330                 335     


Thr Gly Glu Lys Pro Tyr Gln Cys Glu Glu Cys Gly Lys Val Phe Arg 
            340                 345                 350         


Thr Cys Ser Ser Leu Ser Asn His Lys Arg Thr His Ser Glu Glu Lys 
        355                 360                 365             


Pro Tyr Thr Cys Glu Glu Cys Gly Asn Ile Phe Lys Gln Leu Ser Asp 
    370                 375                 380                 


Leu Thr Lys His Lys Lys Thr His Thr Gly Glu Lys Pro Tyr Lys Cys 
385                 390                 395                 400 


Asp Glu Cys Gly Lys Asn Phe Thr Gln Ser Ser Asn Leu Ile Val His 
                405                 410                 415     


Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly 
            420                 425                 430         


Arg Val Phe Met Trp Phe Ser Asp Ile Thr Lys His Lys Lys Thr His 
        435                 440                 445             


Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly Lys Asn Phe Thr 
    450                 455                 460                 


Gln Ser Ser Asn Leu Ile Val His Lys Arg Ile His Thr Gly Glu Lys 
465                 470                 475                 480 


Pro Tyr Lys Cys Glu Lys Cys Gly Lys Ala Phe Thr Gln Phe Ser His 
                485                 490                 495     


Leu Thr Val His Glu Ser Ile His Thr 
            500                 505 

<210>  2630
<211>  3215
<212>  DNA
<213>  Homo sapiens

<400>  2630
aatcaggcac atgtctggag aggagaggac ggcttccggg atctagcggg gcctttgtcc     60

cgacagagct ccacttcctg tccccgcggc tctgtgtccc ctgctagccg taggtcgtgt    120

gacccgcagg caccgggaga tccagaagtg aaacgccagg ctctctggag gccaggagat    180

ggtgtgattt gtccagagaa tctttcctaa gaggaaatcc cagagaagca ggagaaagag    240

aaagaaatgg ctggtgctca gactctgttg acgttcaggg atgtggccat agaattctcc    300

ctggaggagt ggaaatgcct ggacctcgct cagcagaatt tgtacaggga tgtgatgttg    360

gagaactaca gaaacttgtt ctccgttggt ctcactgtct gtaagccagg cctgatcacc    420

tgcctggagc aacgaaaaga gccctggaat gtgaagagac aggaggcagc agacggacat    480

ccagagatgg gatttcacca tgctactcag gcttgtcttg aactcctggg ctcaagcgat    540

ctgcctgcct cagcctccca aagtgctggg attacagcta tgtcttctca ttttacccaa    600

gaccttctgc cagagcaggg catacaagat gcattcccaa aaagaatact gagaggatat    660

ggaaattgtg gccttgataa tttatattta aggaaagact gggaaagttt agatgagtgt    720

aagttgcaaa aagattataa tggacttaac caatgttcat caactaccca tagcaaaatc    780

tttcaatata ataaatatgt taaaatcttt gataactttt caaatttaca tagacgtaat    840

ataagtaata ctggagagaa acctttcaaa tgtcaagaat gtggcaaatc ctttcaaatg    900

ctctcattcc taactgaaca tcagaaaatt cacactggaa aaaaattcca aaaatgtgga    960

gaatgtggca aaacctttat ccagtgctca cactttactg aacctgagaa cattgacact   1020

ggagagaaac cttacaagtg tcaagaatgt aacaacgtca ttaaaacttg ctcagtcctt   1080

actaaaaata gaatttatgc cggaggggaa cattacagat gtgaagaatt tggcaaagta   1140

tttaaccagt gctcccacct tactgaacat gagcatggta ctgaggaaaa accctgcaaa   1200

tatgaagagt gcagcagtgt ctttatctct tgctcaagcc tttctaatca acagatgatt   1260

cttgctggag agaagctctc caaatgtgaa acatggtaca aaggttttaa ccacagccca   1320

aatccttcca aacaccagag aaatgagatt ggagggaaac ctttcaaatg tgaggaatgt   1380

gacagcatct tcaagtggtt ctcagacctt actaaacata agagaattca cactggtgag   1440

aaaccataca aatgtgacga atgtgggaaa gcctatacac agtcctcaca cctcagtgaa   1500

cacaggagga ttcacaccgg agagaaaccc taccaatgtg aagaatgtgg gaaggtcttc   1560

agaacttgct caagcctttc taaccataag agaactcatt ctgaagaaaa accctacacg   1620

tgtgaagaat gtggcaacat ctttaagcag ttatcagacc tcactaagca taagaaaacc   1680

catactggag agaagcccta caaatgtgac gaatgtggaa aaaactttac ccagtcctcc   1740

aaccttattg tacataagag aattcatact ggagagaaac cctacaagtg tgaagaatgt   1800

ggcagagtct tcatgtggtt ctcagacatt accaaacata agaaaaccca tactggagag   1860

aaaccctaca aatgtgacga atgtggaaaa aactttaccc agtcctcaaa ccttattgta   1920

cataagagaa ttcatactgg agagaaaccc tacaagtgtg aaaagtgtgg caaagccttc   1980

acccagttct cacacctgac tgtacatgaa agcattcata cttgagaaaa aaataaacaa   2040

atataaaaat aggcaaagcc gttagtatct gctcgcatcc cactttacat cagagttcag   2100

acttaataaa gttatcataa atgtaattac tattgaaaga cctttcatga aatataagtc   2160

tccagagcac acaagagtat ttcttctgaa aaaaatgtta caattatact agatggaaga   2220

cttgcatcag ttgcttaaac tttcagaaaa tttgtagaga aacccaacaa atctcataaa   2280

tgtggaataa catttgttca aaaatgatag cttagaaaac actagagttc atactaaaag   2340

atattttgca aatacactaa atgggaaaaa taagcaagga cacgttcaga aatgacactg   2400

aatccctgtg ttgagtctac agagacatct agacttaaaa tagatcattt atatttaagt   2460

ttaaaaggag gatgagactg agtttttgta gagttataat tacattcaaa atatactttt   2520

ttgcattgaa aaaatgttaa atttttgaaa agcgaatatt gatgtcattc tattctcaaa   2580

tcagtagatg ctgtgtcttc atttctagtg ctgatgtgaa aacacatggt cagttgttgc   2640

tgcgtcagag atatgagaaa ttcttttctc ttaggtgtgc atcactgata tacttgtccg   2700

tgaaaggtga aagacactga aatgtaagat gcgtgagtaa aatcttggta gagaggctct   2760

ttgtggttgt tttatatact tgtaagtgat ttatgagata ggtgtttaga ataatactct   2820

tctgttaggg tcaccctgat cagaccgttc ccttcccctc ccacaggact tacaatacgg   2880

tcccttgtgc tctctgcaca gctaccccag ggcaaaaaac aaacccccct tcactgatcc   2940

ctccagtaac tgtgcagaca gttacaggat gcggttaaca tgtctgttca cctcgcataa   3000

caaagctggc aaaaaacatc tccaggatgc agacaagaca cctgcaccct cgactaagct   3060

cccccacccc aacccagttc tcctgcaccc ccaactcagc tcccgcaccc cgacctagtt   3120

ctggccctat aaaaacctgc tatagtctgt aagcagggct gcctcctcta actgtggtgg   3180

agcagccaag cagctcaata aagcttgctt gcctg                              3215


<210>  2631
<211>  592
<212>  PRT
<213>  Homo sapiens

<400>  2631


Met Ala Gly Ala Gln Thr Leu Leu Thr Phe Arg Asp Val Ala Ile Glu 
1               5                   10                  15      


Phe Ser Leu Glu Glu Trp Lys Cys Leu Asp Leu Ala Gln Gln Asn Leu 
            20                  25                  30          


Tyr Arg Asp Val Met Leu Glu Asn Tyr Arg Asn Leu Phe Ser Val Gly 
        35                  40                  45              


Leu Thr Val Cys Lys Pro Gly Leu Ile Thr Cys Leu Glu Gln Arg Lys 
    50                  55                  60                  


Glu Pro Trp Asn Val Lys Arg Gln Glu Ala Ala Asp Gly His Pro Glu 
65                  70                  75                  80  


Met Gly Phe His His Ala Thr Gln Ala Cys Leu Glu Leu Leu Gly Ser 
                85                  90                  95      


Ser Asp Leu Pro Ala Ser Ala Ser Gln Ser Ala Gly Ile Thr Ala Met 
            100                 105                 110         


Ser Ser His Phe Thr Gln Asp Leu Leu Pro Glu Gln Gly Ile Gln Asp 
        115                 120                 125             


Ala Phe Pro Lys Arg Ile Leu Arg Gly Tyr Gly Asn Cys Gly Leu Asp 
    130                 135                 140                 


Asn Leu Tyr Leu Arg Lys Asp Trp Glu Ser Leu Asp Glu Cys Lys Leu 
145                 150                 155                 160 


Gln Lys Asp Tyr Asn Gly Leu Asn Gln Cys Ser Ser Thr Thr His Ser 
                165                 170                 175     


Lys Ile Phe Gln Tyr Asn Lys Tyr Val Lys Ile Phe Asp Asn Phe Ser 
            180                 185                 190         


Asn Leu His Arg Arg Asn Ile Ser Asn Thr Gly Glu Lys Pro Phe Lys 
        195                 200                 205             


Cys Gln Glu Cys Gly Lys Ser Phe Gln Met Leu Ser Phe Leu Thr Glu 
    210                 215                 220                 


His Gln Lys Ile His Thr Gly Lys Lys Phe Gln Lys Cys Gly Glu Cys 
225                 230                 235                 240 


Gly Lys Thr Phe Ile Gln Cys Ser His Phe Thr Glu Pro Glu Asn Ile 
                245                 250                 255     


Asp Thr Gly Glu Lys Pro Tyr Lys Cys Gln Glu Cys Asn Asn Val Ile 
            260                 265                 270         


Lys Thr Cys Ser Val Leu Thr Lys Asn Arg Ile Tyr Ala Gly Gly Glu 
        275                 280                 285             


His Tyr Arg Cys Glu Glu Phe Gly Lys Val Phe Asn Gln Cys Ser His 
    290                 295                 300                 


Leu Thr Glu His Glu His Gly Thr Glu Glu Lys Pro Cys Lys Tyr Glu 
305                 310                 315                 320 


Glu Cys Ser Ser Val Phe Ile Ser Cys Ser Ser Leu Ser Asn Gln Gln 
                325                 330                 335     


Met Ile Leu Ala Gly Glu Lys Leu Ser Lys Cys Glu Thr Trp Tyr Lys 
            340                 345                 350         


Gly Phe Asn His Ser Pro Asn Pro Ser Lys His Gln Arg Asn Glu Ile 
        355                 360                 365             


Gly Gly Lys Pro Phe Lys Cys Glu Glu Cys Asp Ser Ile Phe Lys Trp 
    370                 375                 380                 


Phe Ser Asp Leu Thr Lys His Lys Arg Ile His Thr Gly Glu Lys Pro 
385                 390                 395                 400 


Tyr Lys Cys Asp Glu Cys Gly Lys Ala Tyr Thr Gln Ser Ser His Leu 
                405                 410                 415     


Ser Glu His Arg Arg Ile His Thr Gly Glu Lys Pro Tyr Gln Cys Glu 
            420                 425                 430         


Glu Cys Gly Lys Val Phe Arg Thr Cys Ser Ser Leu Ser Asn His Lys 
        435                 440                 445             


Arg Thr His Ser Glu Glu Lys Pro Tyr Thr Cys Glu Glu Cys Gly Asn 
    450                 455                 460                 


Ile Phe Lys Gln Leu Ser Asp Leu Thr Lys His Lys Lys Thr His Thr 
465                 470                 475                 480 


Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly Lys Asn Phe Thr Gln 
                485                 490                 495     


Ser Ser Asn Leu Ile Val His Lys Arg Ile His Thr Gly Glu Lys Pro 
            500                 505                 510         


Tyr Lys Cys Glu Glu Cys Gly Arg Val Phe Met Trp Phe Ser Asp Ile 
        515                 520                 525             


Thr Lys His Lys Lys Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Asp 
    530                 535                 540                 


Glu Cys Gly Lys Asn Phe Thr Gln Ser Ser Asn Leu Ile Val His Lys 
545                 550                 555                 560 


Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Lys Cys Gly Lys 
                565                 570                 575     


Ala Phe Thr Gln Phe Ser His Leu Thr Val His Glu Ser Ile His Thr 
            580                 585                 590         

<210>  2632
<211>  3179
<212>  DNA
<213>  Homo sapiens

<400>  2632
aatcaggcac atgtctggag aggagaggac ggcttccggg atctagcggg gcctttgtcc     60

cgacagagct ccacttcctg tccccgcggc tctgtgtccc ctgctagccg taggtcgtgt    120

gacccgcagg caccgggaga tccagaagtg aaacgccagg ctctctggag gccaggagat    180

ggtgtgattt gtccagagaa tctttcctaa gaggaaatcc cagagaagca ggagaaagag    240

aaagaaatgg ctggtgctca gactctgttg acgttcaggg atgtggccat agaattctcc    300

ctggaggagt ggaaatgcct ggacctcgct cagcagaatt tgtacaggga tgtgatgttg    360

gagaactaca gaaacttgtt ctccgttggt ctcactgtct gtaagccagg cctgatcacc    420

tgcctggagc aacgaaaaga gccctggaat gtgaagagac aggaggcagc agacggacat    480

ccaggtattt tctttgtggt taccatggaa attatataaa acatcttaaa gttacaacaa    540

gctatgtctt ctcattttac ccaagacctt ctgccagagc agggcataca agatgcattc    600

ccaaaaagaa tactgagagg atatggaaat tgtggccttg ataatttata tttaaggaaa    660

gactgggaaa gtttagatga gtgtaagttg caaaaagatt ataatggact taaccaatgt    720

tcatcaacta cccatagcaa aatctttcaa tataataaat atgttaaaat ctttgataac    780

ttttcaaatt tacatagacg taatataagt aatactggag agaaaccttt caaatgtcaa    840

gaatgtggca aatcctttca aatgctctca ttcctaactg aacatcagaa aattcacact    900

ggaaaaaaat tccaaaaatg tggagaatgt ggcaaaacct ttatccagtg ctcacacttt    960

actgaacctg agaacattga cactggagag aaaccttaca agtgtcaaga atgtaacaac   1020

gtcattaaaa cttgctcagt ccttactaaa aatagaattt atgccggagg ggaacattac   1080

agatgtgaag aatttggcaa agtatttaac cagtgctccc accttactga acatgagcat   1140

ggtactgagg aaaaaccctg caaatatgaa gagtgcagca gtgtctttat ctcttgctca   1200

agcctttcta atcaacagat gattcttgct ggagagaagc tctccaaatg tgaaacatgg   1260

tacaaaggtt ttaaccacag cccaaatcct tccaaacacc agagaaatga gattggaggg   1320

aaacctttca aatgtgagga atgtgacagc atcttcaagt ggttctcaga ccttactaaa   1380

cataagagaa ttcacactgg tgagaaacca tacaaatgtg acgaatgtgg gaaagcctat   1440

acacagtcct cacacctcag tgaacacagg aggattcaca ccggagagaa accctaccaa   1500

tgtgaagaat gtgggaaggt cttcagaact tgctcaagcc tttctaacca taagagaact   1560

cattctgaag aaaaacccta cacgtgtgaa gaatgtggca acatctttaa gcagttatca   1620

gacctcacta agcataagaa aacccatact ggagagaagc cctacaaatg tgacgaatgt   1680

ggaaaaaact ttacccagtc ctccaacctt attgtacata agagaattca tactggagag   1740

aaaccctaca agtgtgaaga atgtggcaga gtcttcatgt ggttctcaga cattaccaaa   1800

cataagaaaa cccatactgg agagaaaccc tacaaatgtg acgaatgtgg aaaaaacttt   1860

acccagtcct caaaccttat tgtacataag agaattcata ctggagagaa accctacaag   1920

tgtgaaaagt gtggcaaagc cttcacccag ttctcacacc tgactgtaca tgaaagcatt   1980

catacttgag aaaaaaataa acaaatataa aaataggcaa agccgttagt atctgctcgc   2040

atcccacttt acatcagagt tcagacttaa taaagttatc ataaatgtaa ttactattga   2100

aagacctttc atgaaatata agtctccaga gcacacaaga gtatttcttc tgaaaaaaat   2160

gttacaatta tactagatgg aagacttgca tcagttgctt aaactttcag aaaatttgta   2220

gagaaaccca acaaatctca taaatgtgga ataacatttg ttcaaaaatg atagcttaga   2280

aaacactaga gttcatacta aaagatattt tgcaaataca ctaaatggga aaaataagca   2340

aggacacgtt cagaaatgac actgaatccc tgtgttgagt ctacagagac atctagactt   2400

aaaatagatc atttatattt aagtttaaaa ggaggatgag actgagtttt tgtagagtta   2460

taattacatt caaaatatac ttttttgcat tgaaaaaatg ttaaattttt gaaaagcgaa   2520

tattgatgtc attctattct caaatcagta gatgctgtgt cttcatttct agtgctgatg   2580

tgaaaacaca tggtcagttg ttgctgcgtc agagatatga gaaattcttt tctcttaggt   2640

gtgcatcact gatatacttg tccgtgaaag gtgaaagaca ctgaaatgta agatgcgtga   2700

gtaaaatctt ggtagagagg ctctttgtgg ttgttttata tacttgtaag tgatttatga   2760

gataggtgtt tagaataata ctcttctgtt agggtcaccc tgatcagacc gttcccttcc   2820

cctcccacag gacttacaat acggtccctt gtgctctctg cacagctacc ccagggcaaa   2880

aaacaaaccc cccttcactg atccctccag taactgtgca gacagttaca ggatgcggtt   2940

aacatgtctg ttcacctcgc ataacaaagc tggcaaaaaa catctccagg atgcagacaa   3000

gacacctgca ccctcgacta agctccccca ccccaaccca gttctcctgc acccccaact   3060

cagctcccgc accccgacct agttctggcc ctataaaaac ctgctatagt ctgtaagcag   3120

ggctgcctcc tctaactgtg gtggagcagc caagcagctc aataaagctt gcttgcctg    3179


<210>  2633
<211>  90
<212>  PRT
<213>  Homo sapiens

<400>  2633


Met Ala Gly Ala Gln Thr Leu Leu Thr Phe Arg Asp Val Ala Ile Glu 
1               5                   10                  15      


Phe Ser Leu Glu Glu Trp Lys Cys Leu Asp Leu Ala Gln Gln Asn Leu 
            20                  25                  30          


Tyr Arg Asp Val Met Leu Glu Asn Tyr Arg Asn Leu Phe Ser Val Gly 
        35                  40                  45              


Leu Thr Val Cys Lys Pro Gly Leu Ile Thr Cys Leu Glu Gln Arg Lys 
    50                  55                  60                  


Glu Pro Trp Asn Val Lys Arg Gln Glu Ala Ala Asp Gly His Pro Gly 
65                  70                  75                  80  


Ile Phe Phe Val Val Thr Met Glu Ile Ile 
                85                  90  

<210>  2634
<211>  3135
<212>  DNA
<213>  Homo sapiens

<400>  2634
tggaaactgt ggttataatg tgtcttatgt ccctttttgt ttatactagt tgatgtgttg     60

agcttcttga tttttttgta tttttttctt acttttgaga atttctcagt aattatttcc    120

tttcatacct cagtttctca gtctgttttt catacttcat gtctttttat tggtatcctt    180

attttcctaa ttttacttag tttgctgttt tgccattttt actcattgag cattattcaa    240

atggtaattt tattttcttc agttaattta tgcatctcca tcattttagg gttgatttct    300

gaactttttt tatttctttg attatgccat gtgaccctaa tactttgtac atgtcatctt    360

tgactgagat tcaggcatta acaacaagcc tcctgccaca acctttataa tgtgcctttc    420

tcctggggtc atctaaaaca aataggccca gattctagag gcctcttaag cctgttctgg    480

gatgtgtctt gtgtggaatt gtgtgtgtat ttttcattta aagagggttt ctcagctttc    540

tttgtagtgc cctggaatca cacaatacac ttgtcgcctg gtgctgctgc tgcagccttc    600

ctaccgctgt catgggtatt tcctttcggt ctcagcagac ccagcctgtc actcagagta    660

ccaccatttc tctcagcact ccgtgtcaca gggggcagaa accaatcttt gccaaagctt    720

caaaaggcca aaagtaaaaa cacttgtgcc agtatttgct ttctcttttg aaggagaagc    780

caagagctga gggtgtactc ttaaaggcat gatgctatac tgcggaggag cgggggctgc    840

agtgggtaaa cgtaacagac tgtttttctt cttatctggc tcctagcact gtgctcacct    900

ggggtgctgc aaactgtgaa atggttttta gagttcagat gcatcttctc actagctatg    960

tcttctcatt ttacccaaga ccttctgcca gagcagggca tacaagatgc attcccaaaa   1020

agaatactga gaggatatgg aaattgtggc cttgataatt tatatttaag gaaagactgg   1080

gaaagtttag atgagtgtaa gttgcaaaaa gattataatg gacttaacca atgttcatca   1140

actacccata gcaaaatctt tcaatataat aaatatgtta aaatctttga taacttttca   1200

aatttacata gacgtaatat aagtaatact ggagagaaac ctttcaaatg tcaagaatgt   1260

ggcaaatcct ttcaaatgct ctcattccta actgaacatc agaaaattca cactggaaaa   1320

aaattccaaa aatgtggaga atgtggcaaa acctttatcc agtgctcaca ctttactgaa   1380

cctgagaaca ttgacactgg agagaaacct tacaagtgtc aagaatgtaa caacgtcatt   1440

aaaacttgct cagtccttac taaaaataga atttatgccg gaggggaaca ttacagatgt   1500

gaagaatttg gcaaagtatt taaccagtgc tcccacctta ctgaacatga gcatggtact   1560

gaggaaaaac cctgcaaata tgaagagtgc agcagtgtct ttatctcttg ctcaagcctt   1620

tctaatcaac agatgattct tgctggagag aagctctcca aatgtgaaac atggtacaaa   1680

ggttttaacc acagcccaaa tccttccaaa caccagagaa atgagattgg agggaaacct   1740

ttcaaatgtg aggaatgtga cagcatcttc aagtggttct cagaccttac taaacataag   1800

agaattcaca ctggtgagaa accatacaaa tgtgacgaat gtgggaaagc ctatacacag   1860

tcctcacacc tcagtgaaca caggaggatt cacaccggag agaaacccta ccaatgtgaa   1920

gaatgtggga aggtcttcag aacttgctca agcctttcta accataagag aactcattct   1980

gaagaaaaac cctacacgtg tgaagaatgt ggcaacatct ttaagcagtt atcagacctc   2040

actaagcata agaaaaccca tactggagag aagccctaca aatgtgacga atgtggaaaa   2100

aactttaccc agtcctccaa ccttattgta cataagagaa ttcatactgg agagaaaccc   2160

tacaagtgtg aagaatgtgg cagagtcttc atgtggttct cagacattac caaacataag   2220

aaaacccata ctggagagaa accctacaaa tgtgacgaat gtggaaaaaa ctttacccag   2280

tcctcaaacc ttattgtaca taagagaatt catactggag agaaacccta caagtgtgaa   2340

aagtgtggca aagccttcac ccagttctca cacctgactg tacatgaaag cattcatact   2400

tgagaaaaaa ataaacaaat ataaaaatag gcaaagccgt tagtatctgc tcgcatccca   2460

ctttacatca gagttcagac ttaataaagt tatcataaat gtaattacta ttgaaagacc   2520

tttcatgaaa tataagtctc cagagcacac aagagtattt cttctgaaaa aaatgttaca   2580

attatactag atggaagact tgcatcagtt gcttaaactt tcagaaaatt tgtagagaaa   2640

cccaacaaat ctcataaatg tggaataaca tttgttcaaa aatgatagct tagaaaacac   2700

tagagttcat actaaaagat attttgcaaa tacactaaat gggaaaaata agcaaggaca   2760

cgttcagaaa tgacactgaa tccctgtgtt gagtctacag agacatctag acttaaaata   2820

gatcatttat atttaagttt aaaaggagga tgagactgag tttttgtaga gttataatta   2880

cattcaaaat atactttttt gcattgaaaa aatgttaaat ttttgaaaag cgaatattga   2940

tgtcattcta ttctcaaatc agtagatgct gtgtcttcat ttctagtgct gatgtgaaaa   3000

cacatggtca gttgttgctg cgtcagagat atgagaaatt cttttctctt aggtgtgcat   3060

cactgatata cttgtccgtg aaaggtgaaa gacactgaaa tgtaagatgc gtgagtaaaa   3120

tcttggtaga gaggc                                                    3135


<210>  2635
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  2635


Met Val Phe Arg Val Gln Met His Leu Leu Thr Ser Tyr Val Phe Ser 
1               5                   10                  15      


Phe Tyr Pro Arg Pro Ser Ala Arg Ala Gly His Thr Arg Cys Ile Pro 
            20                  25                  30          


Lys Lys Asn Thr Glu Arg Ile Trp Lys Leu Trp Pro 
        35                  40                  

<210>  2636
<211>  2626
<212>  DNA
<213>  Homo sapiens

<400>  2636
cagctgtagt ttgatcttag tttggtttta aattatttag catatgcctt ttgattgagt     60

agtttagttc ctaaataagc aatttactga aatgaaaaga tgtactttag ccattgtatt    120

ttttttactt gattcttgta gctttttctt tctctctttc ctttttgtgt cttgtacttt    180

gtataataag ctttgactct ttttaaattt tcttttgtgt gtcttatagg tattttcttt    240

gtggttacca tggaaattat ataaaacatc ttaaagttac aacaaggtat tttacactga    300

gatgggattt caccatgcta ctcaggcttg tcttgaactc ctgggctcaa gcgatctgcc    360

tgcctcagcc tcccaaagtg ctgggattac aggtgtgaac caccgtgccc agccaggcct    420

caatgtttct gtggacaaat tcactgctat gtcttctcat tttacccaag accttctgcc    480

agagcagggc atacaagatg cattcccaaa aagaatactg agaggatatg gaaattgtgg    540

ccttgataat ttatatttaa ggaaagactg ggaaagttta gatgagtgta agttgcaaaa    600

agattataat ggacttaacc aatgttcatc aactacccat agcaaaatct ttcaatataa    660

taaatatgtt aaaatctttg ataacttttc aaatttacat agacgtaata taagtaatac    720

tggagagaaa cctttcaaat gtcaagaatg tggcaaatcc tttcaaatgc tctcattcct    780

aactgaacat cagaaaattc acactggaaa aaaattccaa aaatgtggag aatgtggcaa    840

aacctttatc cagtgctcac actttactga acctgagaac attgacactg gagagaaacc    900

ttacaagtgt caagaatgta acaacgtcat taaaacttgc tcagtcctta ctaaaaatag    960

aatttatgcc ggaggggaac attacagatg tgaagaattt ggcaaagtat ttaaccagtg   1020

ctcccacctt actgaacatg agcatggtac tgaggaaaaa ccctgcaaat atgaagagtg   1080

cagcagtgtc tttatctctt gctcaagcct ttctaatcaa cagatgattc ttgctggaga   1140

gaagctctcc aaatgtgaaa catggtacaa aggttttaac cacagcccaa atccttccaa   1200

acaccagaga aatgagattg gagggaaacc tttcaaatgt gaggaatgtg acagcatctt   1260

caagtggttc tcagacctta ctaaacataa gagaattcac actggtgaga aaccatacaa   1320

atgtgacgaa tgtgggaaag cctatacaca gtcctcacac ctcagtgaac acaggaggat   1380

tcacaccgga gagaaaccct accaatgtga agaatgtggg aaggtcttca gaacttgctc   1440

aagcctttct aaccataaga gaactcattc tgaagaaaaa ccctacacgt gtgaagaatg   1500

tggcaacatc tttaagcagt tatcagacct cactaagcat aagaaaaccc atactggaga   1560

gaagccctac aaatgtgacg aatgtggaaa aaactttacc cagtcctcca accttattgt   1620

acataagaga attcatactg gagagaaacc ctacaagtgt gaagaatgtg gcagagtctt   1680

catgtggttc tcagacatta ccaaacataa gaaaacccat actggagaga aaccctacaa   1740

atgtgacgaa tgtggaaaaa actttaccca gtcctcaaac cttattgtac ataagagaat   1800

tcatactgga gagaaaccct acaagtgtga aaagtgtggc aaagccttca cccagttctc   1860

acacctgact gtacatgaaa gcattcatac ttgagaaaaa aataaacaaa tataaaaata   1920

ggcaaagccg ttagtatctg ctcgcatccc actttacatc agagttcaga cttaataaag   1980

ttatcataaa tgtaattact attgaaagac ctttcatgaa atataagtct ccagagcaca   2040

caagagtatt tcttctgaaa aaaatgttac aattatacta gatggaagac ttgcatcagt   2100

tgcttaaact ttcagaaaat ttgtagagaa acccaacaaa tctcataaat gtggaataac   2160

atttgttcaa aaatgatagc ttagaaaaca ctagagttca tactaaaaga tattttgcaa   2220

atacactaaa tgggaaaaat aagcaaggac acgttcagaa atgacactga atccctgtgt   2280

tgagtctaca gagacatcta gacttaaaat agatcattta tatttaagtt taaaaggagg   2340

atgagactga gtttttgtag agttataatt acattcaaaa tatacttttt tgcattgaaa   2400

aaatgttaaa tttttgaaaa gcgaatattg atgtcattct attctcaaat cagtagatgc   2460

tgtgtcttca tttctagtgc tgatgtgaaa acacatggtc agttgttgct gcgtcagaga   2520

tatgagaaat tcttttctct taggtgtgca tcactgatat acttgtccgt gaaaggtgaa   2580

agacactgaa atgtaagatg cgtgagtaaa atcttggtag agaggc                  2626


<210>  2637
<211>  530
<212>  PRT
<213>  Homo sapiens

<400>  2637


Met Gly Phe His His Ala Thr Gln Ala Cys Leu Glu Leu Leu Gly Ser 
1               5                   10                  15      


Ser Asp Leu Pro Ala Ser Ala Ser Gln Ser Ala Gly Ile Thr Gly Val 
            20                  25                  30          


Asn His Arg Ala Gln Pro Gly Leu Asn Val Ser Val Asp Lys Phe Thr 
        35                  40                  45              


Ala Met Ser Ser His Phe Thr Gln Asp Leu Leu Pro Glu Gln Gly Ile 
    50                  55                  60                  


Gln Asp Ala Phe Pro Lys Arg Ile Leu Arg Gly Tyr Gly Asn Cys Gly 
65                  70                  75                  80  


Leu Asp Asn Leu Tyr Leu Arg Lys Asp Trp Glu Ser Leu Asp Glu Cys 
                85                  90                  95      


Lys Leu Gln Lys Asp Tyr Asn Gly Leu Asn Gln Cys Ser Ser Thr Thr 
            100                 105                 110         


His Ser Lys Ile Phe Gln Tyr Asn Lys Tyr Val Lys Ile Phe Asp Asn 
        115                 120                 125             


Phe Ser Asn Leu His Arg Arg Asn Ile Ser Asn Thr Gly Glu Lys Pro 
    130                 135                 140                 


Phe Lys Cys Gln Glu Cys Gly Lys Ser Phe Gln Met Leu Ser Phe Leu 
145                 150                 155                 160 


Thr Glu His Gln Lys Ile His Thr Gly Lys Lys Phe Gln Lys Cys Gly 
                165                 170                 175     


Glu Cys Gly Lys Thr Phe Ile Gln Cys Ser His Phe Thr Glu Pro Glu 
            180                 185                 190         


Asn Ile Asp Thr Gly Glu Lys Pro Tyr Lys Cys Gln Glu Cys Asn Asn 
        195                 200                 205             


Val Ile Lys Thr Cys Ser Val Leu Thr Lys Asn Arg Ile Tyr Ala Gly 
    210                 215                 220                 


Gly Glu His Tyr Arg Cys Glu Glu Phe Gly Lys Val Phe Asn Gln Cys 
225                 230                 235                 240 


Ser His Leu Thr Glu His Glu His Gly Thr Glu Glu Lys Pro Cys Lys 
                245                 250                 255     


Tyr Glu Glu Cys Ser Ser Val Phe Ile Ser Cys Ser Ser Leu Ser Asn 
            260                 265                 270         


Gln Gln Met Ile Leu Ala Gly Glu Lys Leu Ser Lys Cys Glu Thr Trp 
        275                 280                 285             


Tyr Lys Gly Phe Asn His Ser Pro Asn Pro Ser Lys His Gln Arg Asn 
    290                 295                 300                 


Glu Ile Gly Gly Lys Pro Phe Lys Cys Glu Glu Cys Asp Ser Ile Phe 
305                 310                 315                 320 


Lys Trp Phe Ser Asp Leu Thr Lys His Lys Arg Ile His Thr Gly Glu 
                325                 330                 335     


Lys Pro Tyr Lys Cys Asp Glu Cys Gly Lys Ala Tyr Thr Gln Ser Ser 
            340                 345                 350         


His Leu Ser Glu His Arg Arg Ile His Thr Gly Glu Lys Pro Tyr Gln 
        355                 360                 365             


Cys Glu Glu Cys Gly Lys Val Phe Arg Thr Cys Ser Ser Leu Ser Asn 
    370                 375                 380                 


His Lys Arg Thr His Ser Glu Glu Lys Pro Tyr Thr Cys Glu Glu Cys 
385                 390                 395                 400 


Gly Asn Ile Phe Lys Gln Leu Ser Asp Leu Thr Lys His Lys Lys Thr 
                405                 410                 415     


His Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly Lys Asn Phe 
            420                 425                 430         


Thr Gln Ser Ser Asn Leu Ile Val His Lys Arg Ile His Thr Gly Glu 
        435                 440                 445             


Lys Pro Tyr Lys Cys Glu Glu Cys Gly Arg Val Phe Met Trp Phe Ser 
    450                 455                 460                 


Asp Ile Thr Lys His Lys Lys Thr His Thr Gly Glu Lys Pro Tyr Lys 
465                 470                 475                 480 


Cys Asp Glu Cys Gly Lys Asn Phe Thr Gln Ser Ser Asn Leu Ile Val 
                485                 490                 495     


His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Lys Cys 
            500                 505                 510         


Gly Lys Ala Phe Thr Gln Phe Ser His Leu Thr Val His Glu Ser Ile 
        515                 520                 525             


His Thr 
    530 

<210>  2638
<211>  3004
<212>  DNA
<213>  Homo sapiens

<400>  2638
cttttcataa tgattgtagt gcattttctg tgaaatgtta ctgctgtcca ctgcatgcca     60

gtgactcaaa atacctagtt ttcatgacta cacagtcaca gttgaatact gtagttatct    120

aggcaaattc ttttttaatg gtacatcaat gtttcatagc agattttatg actaacatct    180

cttagtgttt tgtaattcca tattactgtt tttatggttg aataatattc cttgtatgta    240

tataccacat tttttctgtg tgttcatcac ttgaggcttc ccccatttga cttttctgaa    300

tagtggtaca gtaaacatgg gtgtgcaaat atctcttcta agtcctgagt tgctttgtat    360

acttttgata tagatctaga aatgggattg ctggatcata taattccatt tttaattttt    420

ttaagaaaat tatgcttttt tttttttttt tacacagagt ttcactctat cacccaggct    480

gtagtgcagt ggtgccatct cagctcactg caacctctgc ttcctgggct cgagccttct    540

tcccacttca gcctcctgag gacctggaac tacaggggca caccgccaca cccagctaac    600

ttttgtgttt ttaatagaga cagggttttg ccatgttgcc caggctggtc tcggactcct    660

gggctcaagt gatccacccg cctcggtctc ccgaagtgct ggggttccag gtgtgagctg    720

gtgtgaacca gtgtgcccgg cctatgctat ctttcatcgt ggctgcatcc tttctttcct    780

accagcaggt tacgtggttt tcaatgtctt cacatccttg acagctatgt cttctcattt    840

tacccaagac cttctgccag agcagggcat acaagatgca ttcccaaaaa gaatactgag    900

aggatatgga aattgtggcc ttgataattt atatttaagg aaagactggg aaagtttaga    960

tgagtgtaag ttgcaaaaag attataatgg acttaaccaa tgttcatcaa ctacccatag   1020

caaaatcttt caatataata aatatgttaa aatctttgat aacttttcaa atttacatag   1080

acgtaatata agtaatactg gagagaaacc tttcaaatgt caagaatgtg gcaaatcctt   1140

tcaaatgctc tcattcctaa ctgaacatca gaaaattcac actggaaaaa aattccaaaa   1200

atgtggagaa tgtggcaaaa cctttatcca gtgctcacac tttactgaac ctgagaacat   1260

tgacactgga gagaaacctt acaagtgtca agaatgtaac aacgtcatta aaacttgctc   1320

agtccttact aaaaatagaa tttatgccgg aggggaacat tacagatgtg aagaatttgg   1380

caaagtattt aaccagtgct cccaccttac tgaacatgag catggtactg aggaaaaacc   1440

ctgcaaatat gaagagtgca gcagtgtctt tatctcttgc tcaagccttt ctaatcaaca   1500

gatgattctt gctggagaga agctctccaa atgtgaaaca tggtacaaag gttttaacca   1560

cagcccaaat ccttccaaac accagagaaa tgagattgga gggaaacctt tcaaatgtga   1620

ggaatgtgac agcatcttca agtggttctc agaccttact aaacataaga gaattcacac   1680

tggtgagaaa ccatacaaat gtgacgaatg tgggaaagcc tatacacagt cctcacacct   1740

cagtgaacac aggaggattc acaccggaga gaaaccctac caatgtgaag aatgtgggaa   1800

ggtcttcaga acttgctcaa gcctttctaa ccataagaga actcattctg aagaaaaacc   1860

ctacacgtgt gaagaatgtg gcaacatctt taagcagtta tcagacctca ctaagcataa   1920

gaaaacccat actggagaga agccctacaa atgtgacgaa tgtggaaaaa actttaccca   1980

gtcctccaac cttattgtac ataagagaat tcatactgga gagaaaccct acaagtgtga   2040

agaatgtggc agagtcttca tgtggttctc agacattacc aaacataaga aaacccatac   2100

tggagagaaa ccctacaaat gtgacgaatg tggaaaaaac tttacccagt cctcaaacct   2160

tattgtacat aagagaattc atactggaga gaaaccctac aagtgtgaaa agtgtggcaa   2220

agccttcacc cagttctcac acctgactgt acatgaaagc attcatactt gagaaaaaaa   2280

taaacaaata taaaaatagg caaagccgtt agtatctgct cgcatcccac tttacatcag   2340

agttcagact taataaagtt atcataaatg taattactat tgaaagacct ttcatgaaat   2400

ataagtctcc agagcacaca agagtatttc ttctgaaaaa aatgttacaa ttatactaga   2460

tggaagactt gcatcagttg cttaaacttt cagaaaattt gtagagaaac ccaacaaatc   2520

tcataaatgt ggaataacat ttgttcaaaa atgatagctt agaaaacact agagttcata   2580

ctaaaagata ttttgcaaat acactaaatg ggaaaaataa gcaaggacac gttcagaaat   2640

gacactgaat ccctgtgttg agtctacaga gacatctaga cttaaaatag atcatttata   2700

tttaagttta aaaggaggat gagactgagt ttttgtagag ttataattac attcaaaata   2760

tacttttttg cattgaaaaa atgttaaatt tttgaaaagc gaatattgat gtcattctat   2820

tctcaaatca gtagatgctg tgtcttcatt tctagtgctg atgtgaaaac acatggtcag   2880

ttgttgctgc gtcagagata tgagaaattc ttttctctta ggtgtgcatc actgatatac   2940

ttgtccgtga aaggtgaaag acactgaaat gtaagatgcg tgagtaaaat cttggtagag   3000

aggc                                                                3004


<210>  2639
<211>  481
<212>  PRT
<213>  Homo sapiens

<400>  2639


Met Ser Ser His Phe Thr Gln Asp Leu Leu Pro Glu Gln Gly Ile Gln 
1               5                   10                  15      


Asp Ala Phe Pro Lys Arg Ile Leu Arg Gly Tyr Gly Asn Cys Gly Leu 
            20                  25                  30          


Asp Asn Leu Tyr Leu Arg Lys Asp Trp Glu Ser Leu Asp Glu Cys Lys 
        35                  40                  45              


Leu Gln Lys Asp Tyr Asn Gly Leu Asn Gln Cys Ser Ser Thr Thr His 
    50                  55                  60                  


Ser Lys Ile Phe Gln Tyr Asn Lys Tyr Val Lys Ile Phe Asp Asn Phe 
65                  70                  75                  80  


Ser Asn Leu His Arg Arg Asn Ile Ser Asn Thr Gly Glu Lys Pro Phe 
                85                  90                  95      


Lys Cys Gln Glu Cys Gly Lys Ser Phe Gln Met Leu Ser Phe Leu Thr 
            100                 105                 110         


Glu His Gln Lys Ile His Thr Gly Lys Lys Phe Gln Lys Cys Gly Glu 
        115                 120                 125             


Cys Gly Lys Thr Phe Ile Gln Cys Ser His Phe Thr Glu Pro Glu Asn 
    130                 135                 140                 


Ile Asp Thr Gly Glu Lys Pro Tyr Lys Cys Gln Glu Cys Asn Asn Val 
145                 150                 155                 160 


Ile Lys Thr Cys Ser Val Leu Thr Lys Asn Arg Ile Tyr Ala Gly Gly 
                165                 170                 175     


Glu His Tyr Arg Cys Glu Glu Phe Gly Lys Val Phe Asn Gln Cys Ser 
            180                 185                 190         


His Leu Thr Glu His Glu His Gly Thr Glu Glu Lys Pro Cys Lys Tyr 
        195                 200                 205             


Glu Glu Cys Ser Ser Val Phe Ile Ser Cys Ser Ser Leu Ser Asn Gln 
    210                 215                 220                 


Gln Met Ile Leu Ala Gly Glu Lys Leu Ser Lys Cys Glu Thr Trp Tyr 
225                 230                 235                 240 


Lys Gly Phe Asn His Ser Pro Asn Pro Ser Lys His Gln Arg Asn Glu 
                245                 250                 255     


Ile Gly Gly Lys Pro Phe Lys Cys Glu Glu Cys Asp Ser Ile Phe Lys 
            260                 265                 270         


Trp Phe Ser Asp Leu Thr Lys His Lys Arg Ile His Thr Gly Glu Lys 
        275                 280                 285             


Pro Tyr Lys Cys Asp Glu Cys Gly Lys Ala Tyr Thr Gln Ser Ser His 
    290                 295                 300                 


Leu Ser Glu His Arg Arg Ile His Thr Gly Glu Lys Pro Tyr Gln Cys 
305                 310                 315                 320 


Glu Glu Cys Gly Lys Val Phe Arg Thr Cys Ser Ser Leu Ser Asn His 
                325                 330                 335     


Lys Arg Thr His Ser Glu Glu Lys Pro Tyr Thr Cys Glu Glu Cys Gly 
            340                 345                 350         


Asn Ile Phe Lys Gln Leu Ser Asp Leu Thr Lys His Lys Lys Thr His 
        355                 360                 365             


Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly Lys Asn Phe Thr 
    370                 375                 380                 


Gln Ser Ser Asn Leu Ile Val His Lys Arg Ile His Thr Gly Glu Lys 
385                 390                 395                 400 


Pro Tyr Lys Cys Glu Glu Cys Gly Arg Val Phe Met Trp Phe Ser Asp 
                405                 410                 415     


Ile Thr Lys His Lys Lys Thr His Thr Gly Glu Lys Pro Tyr Lys Cys 
            420                 425                 430         


Asp Glu Cys Gly Lys Asn Phe Thr Gln Ser Ser Asn Leu Ile Val His 
        435                 440                 445             


Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Lys Cys Gly 
    450                 455                 460                 


Lys Ala Phe Thr Gln Phe Ser His Leu Thr Val His Glu Ser Ile His 
465                 470                 475                 480 


Thr 
    

<210>  2640
<211>  2500
<212>  DNA
<213>  Homo sapiens

<400>  2640
actctactaa gcacagtaca aggttgataa ttggagaatt tcagcaagag taatgtcact     60

tttttctaat aaaacaggtc tcactgtctg taagccaggc ctgatcacct gcctggagca    120

acgaaaagag ccctggaatg tgaagagaca ggaggcagca gacggacatc cagagatggg    180

atttcaccat gctactcagg cttgtcttga actcctgggc tcaagcgatc tgcctgcctc    240

agcctcccaa agtgctggga ttacaggtgt gaaccaccgt gcccagccag gcctcaatgt    300

ttctgtggac aaattcactg ctatgtcttc tcattttacc caagaccttc tgccagagca    360

gggcatacaa gatgcattcc caaaaagaat actgagagga tatggaaatt gtggccttga    420

taatttatat ttaaggaaag actgggaaag tttagatgag tgtaagttgc aaaaagatta    480

taatggactt aaccaatgtt catcaactac ccatagcaaa atctttcaat ataataaata    540

tgttaaaatc tttgataact tttcaaattt acatagacgt aatataagta atactggaga    600

gaaacctttc aaatgtcaag aatgtggcaa atcctttcaa atgctctcat tcctaactga    660

acatcagaaa attcacactg gaaaaaaatt ccaaaaatgt ggagaatgtg gcaaaacctt    720

tatccagtgc tcacacttta ctgaacctga gaacattgac actggagaga aaccttacaa    780

gtgtcaagaa tgtaacaacg tcattaaaac ttgctcagtc cttactaaaa atagaattta    840

tgccggaggg gaacattaca gatgtgaaga atttggcaaa gtatttaacc agtgctccca    900

ccttactgaa catgagcatg gtactgagga aaaaccctgc aaatatgaag agtgcagcag    960

tgtctttatc tcttgctcaa gcctttctaa tcaacagatg attcttgctg gagagaagct   1020

ctccaaatgt gaaacatggt acaaaggttt taaccacagc ccaaatcctt ccaaacacca   1080

gagaaatgag attggaggga aacctttcaa atgtgaggaa tgtgacagca tcttcaagtg   1140

gttctcagac cttactaaac ataagagaat tcacactggt gagaaaccat acaaatgtga   1200

cgaatgtggg aaagcctata cacagtcctc acacctcagt gaacacagga ggattcacac   1260

cggagagaaa ccctaccaat gtgaagaatg tgggaaggtc ttcagaactt gctcaagcct   1320

ttctaaccat aagagaactc attctgaaga aaaaccctac acgtgtgaag aatgtggcaa   1380

catctttaag cagttatcag acctcactaa gcataagaaa acccatactg gagagaagcc   1440

ctacaaatgt gacgaatgtg gaaaaaactt tacccagtcc tccaacctta ttgtacataa   1500

gagaattcat actggagaga aaccctacaa gtgtgaagaa tgtggcagag tcttcatgtg   1560

gttctcagac attaccaaac ataagaaaac ccatactgga gagaaaccct acaaatgtga   1620

cgaatgtgga aaaaacttta cccagtcctc aaaccttatt gtacataaga gaattcatac   1680

tggagagaaa ccctacaagt gtgaaaagtg tggcaaagcc ttcacccagt tctcacacct   1740

gactgtacat gaaagcattc atacttgaga aaaaaataaa caaatataaa aataggcaaa   1800

gccgttagta tctgctcgca tcccacttta catcagagtt cagacttaat aaagttatca   1860

taaatgtaat tactattgaa agacctttca tgaaatataa gtctccagag cacacaagag   1920

tatttcttct gaaaaaaatg ttacaattat actagatgga agacttgcat cagttgctta   1980

aactttcaga aaatttgtag agaaacccaa caaatctcat aaatgtggaa taacatttgt   2040

tcaaaaatga tagcttagaa aacactagag ttcatactaa aagatatttt gcaaatacac   2100

taaatgggaa aaataagcaa ggacacgttc agaaatgaca ctgaatccct gtgttgagtc   2160

tacagagaca tctagactta aaatagatca tttatattta agtttaaaag gaggatgaga   2220

ctgagttttt gtagagttat aattacattc aaaatatact tttttgcatt gaaaaaatgt   2280

taaatttttg aaaagcgaat attgatgtca ttctattctc aaatcagtag atgctgtgtc   2340

ttcatttcta gtgctgatgt gaaaacacat ggtcagttgt tgctgcgtca gagatatgag   2400

aaattctttt ctcttaggtg tgcatcactg atatacttgt ccgtgaaagg tgaaagacac   2460

tgaaatgtaa gatgcgtgag taaaatcttg gtagagaggc                         2500


<210>  2641
<211>  571
<212>  PRT
<213>  Homo sapiens

<400>  2641


Met Ser Leu Phe Ser Asn Lys Thr Gly Leu Thr Val Cys Lys Pro Gly 
1               5                   10                  15      


Leu Ile Thr Cys Leu Glu Gln Arg Lys Glu Pro Trp Asn Val Lys Arg 
            20                  25                  30          


Gln Glu Ala Ala Asp Gly His Pro Glu Met Gly Phe His His Ala Thr 
        35                  40                  45              


Gln Ala Cys Leu Glu Leu Leu Gly Ser Ser Asp Leu Pro Ala Ser Ala 
    50                  55                  60                  


Ser Gln Ser Ala Gly Ile Thr Gly Val Asn His Arg Ala Gln Pro Gly 
65                  70                  75                  80  


Leu Asn Val Ser Val Asp Lys Phe Thr Ala Met Ser Ser His Phe Thr 
                85                  90                  95      


Gln Asp Leu Leu Pro Glu Gln Gly Ile Gln Asp Ala Phe Pro Lys Arg 
            100                 105                 110         


Ile Leu Arg Gly Tyr Gly Asn Cys Gly Leu Asp Asn Leu Tyr Leu Arg 
        115                 120                 125             


Lys Asp Trp Glu Ser Leu Asp Glu Cys Lys Leu Gln Lys Asp Tyr Asn 
    130                 135                 140                 


Gly Leu Asn Gln Cys Ser Ser Thr Thr His Ser Lys Ile Phe Gln Tyr 
145                 150                 155                 160 


Asn Lys Tyr Val Lys Ile Phe Asp Asn Phe Ser Asn Leu His Arg Arg 
                165                 170                 175     


Asn Ile Ser Asn Thr Gly Glu Lys Pro Phe Lys Cys Gln Glu Cys Gly 
            180                 185                 190         


Lys Ser Phe Gln Met Leu Ser Phe Leu Thr Glu His Gln Lys Ile His 
        195                 200                 205             


Thr Gly Lys Lys Phe Gln Lys Cys Gly Glu Cys Gly Lys Thr Phe Ile 
    210                 215                 220                 


Gln Cys Ser His Phe Thr Glu Pro Glu Asn Ile Asp Thr Gly Glu Lys 
225                 230                 235                 240 


Pro Tyr Lys Cys Gln Glu Cys Asn Asn Val Ile Lys Thr Cys Ser Val 
                245                 250                 255     


Leu Thr Lys Asn Arg Ile Tyr Ala Gly Gly Glu His Tyr Arg Cys Glu 
            260                 265                 270         


Glu Phe Gly Lys Val Phe Asn Gln Cys Ser His Leu Thr Glu His Glu 
        275                 280                 285             


His Gly Thr Glu Glu Lys Pro Cys Lys Tyr Glu Glu Cys Ser Ser Val 
    290                 295                 300                 


Phe Ile Ser Cys Ser Ser Leu Ser Asn Gln Gln Met Ile Leu Ala Gly 
305                 310                 315                 320 


Glu Lys Leu Ser Lys Cys Glu Thr Trp Tyr Lys Gly Phe Asn His Ser 
                325                 330                 335     


Pro Asn Pro Ser Lys His Gln Arg Asn Glu Ile Gly Gly Lys Pro Phe 
            340                 345                 350         


Lys Cys Glu Glu Cys Asp Ser Ile Phe Lys Trp Phe Ser Asp Leu Thr 
        355                 360                 365             


Lys His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu 
    370                 375                 380                 


Cys Gly Lys Ala Tyr Thr Gln Ser Ser His Leu Ser Glu His Arg Arg 
385                 390                 395                 400 


Ile His Thr Gly Glu Lys Pro Tyr Gln Cys Glu Glu Cys Gly Lys Val 
                405                 410                 415     


Phe Arg Thr Cys Ser Ser Leu Ser Asn His Lys Arg Thr His Ser Glu 
            420                 425                 430         


Glu Lys Pro Tyr Thr Cys Glu Glu Cys Gly Asn Ile Phe Lys Gln Leu 
        435                 440                 445             


Ser Asp Leu Thr Lys His Lys Lys Thr His Thr Gly Glu Lys Pro Tyr 
    450                 455                 460                 


Lys Cys Asp Glu Cys Gly Lys Asn Phe Thr Gln Ser Ser Asn Leu Ile 
465                 470                 475                 480 


Val His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu 
                485                 490                 495     


Cys Gly Arg Val Phe Met Trp Phe Ser Asp Ile Thr Lys His Lys Lys 
            500                 505                 510         


Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly Lys Asn 
        515                 520                 525             


Phe Thr Gln Ser Ser Asn Leu Ile Val His Lys Arg Ile His Thr Gly 
    530                 535                 540                 


Glu Lys Pro Tyr Lys Cys Glu Lys Cys Gly Lys Ala Phe Thr Gln Phe 
545                 550                 555                 560 


Ser His Leu Thr Val His Glu Ser Ile His Thr 
                565                 570     

<210>  2642
<211>  2973
<212>  DNA
<213>  Homo sapiens

<400>  2642
gtgtcccctg ctagccgtag gtcgtgtgac ccgcaggcac cgggagatcc agaagtgaaa     60

cgccaggctc tctggaggcc aggagatgtt tcagtattgt ccagggataa cacaggatgc    120

ccaccatggc catgtctgct ggagcatcta gtgaatttca ggccctgggt tatttctcag    180

aggacagcct gaggtatgaa gtgtggcctc tccagggagc agctggatgc cctgggctga    240

gagaaatctc ctggtctact cttcctctaa agaggtgtga tttgtccaga gaatctttcc    300

taagaggaaa tcccagagaa gcaggagaaa gagaaagaaa tggctggtgc tcagactctg    360

ttgacgttca gggatgtggc catagaattc tccctggagg agtggaaatg cctggacctc    420

gctcagcaga atttgtacag ggatgtgatg ttggagaact acagaaactt gttctccgtt    480

ggtctcactg tctgtaagcc aggcctgatc acctgcctgg agcaacgaaa agagccctgg    540

aatgtgaaga gacaggaggc agcagacgga catccagaga tgggatttca ccatgctact    600

caggcttgtc ttgaactcct gggctcaagc gatctgcctg cctcagcctc ccaaagtgct    660

gggattacag gtgtgaacca ccgtgcccag ccaggcctca atgtttctgt ggacaaattc    720

actgcactgt gctcacctgg ggtgctgcaa actgtgaaat ggtttttaga gttcagatgc    780

atcttctcac tagctatgtc ttctcatttt acccaagacc ttctgccaga gcagggcata    840

caagatgcat tcccaaaaag aatactgaga ggatatggaa attgtggcct tgataattta    900

tatttaagga aagactggga aagtttagat gagtgtaagt tgcaaaaaga ttataatgga    960

cttaaccaat gttcatcaac tacccatagc aaaatctttc aatataataa atatgttaaa   1020

atctttgata acttttcaaa tttacataga cgtaatataa gtaatactgg agagaaacct   1080

ttcaaatgtc aagaatgtgg caaatccttt caaatgctct cattcctaac tgaacatcag   1140

aaaattcaca ctggaaaaaa attccaaaaa tgtggagaat gtggcaaaac ctttatccag   1200

tgctcacact ttactgaacc tgagaacatt gacactggag agaaacctta caagtgtcaa   1260

gaatgtaaca acgtcattaa aacttgctca gtccttacta aaaatagaat ttatgccgga   1320

ggggaacatt acagatgtga agaatttggc aaagtattta accagtgctc ccaccttact   1380

gaacatgagc atggtactga ggaaaaaccc tgcaaatatg aagagtgcag cagtgtcttt   1440

atctcttgct caagcctttc taatcaacag atgattcttg ctggagagaa gctctccaaa   1500

tgtgaaacat ggtacaaagg ttttaaccac agcccaaatc cttccaaaca ccagagaaat   1560

gagattggag ggaaaccttt caaatgtgag gaatgtgaca gcatcttcaa gtggttctca   1620

gaccttacta aacataagag aattcacact ggtgagaaac catacaaatg tgacgaatgt   1680

gggaaagcct atacacagtc ctcacacctc agtgaacaca ggaggattca caccggagag   1740

aaaccctacc aatgtgaaga atgtgggaag gtcttcagaa cttgctcaag cctttctaac   1800

cataagagaa ctcattctga agaaaaaccc tacacgtgtg aagaatgtgg caacatcttt   1860

aagcagttat cagacctcac taagcataag aaaacccata ctggagagaa gccctacaaa   1920

tgtgacgaat gtggaaaaaa ctttacccag tcctccaacc ttattgtaca taagagaatt   1980

catactggag agaaacccta caagtgtgaa gaatgtggca gagtcttcat gtggttctca   2040

gacattacca aacataagaa aacccatact ggagagaaac cctacaaatg tgacgaatgt   2100

ggaaaaaact ttacccagtc ctcaaacctt attgtacata agagaattca tactggagag   2160

aaaccctaca agtgtgaaaa gtgtggcaaa gccttcaccc agttctcaca cctgactgta   2220

catgaaagca ttcatacttg agaaaaaaat aaacaaatat aaaaataggc aaagccgtta   2280

gtatctgctc gcatcccact ttacatcaga gttcagactt aataaagtta tcataaatgt   2340

aattactatt gaaagacctt tcatgaaata taagtctcca gagcacacaa gagtatttct   2400

tctgaaaaaa atgttacaat tatactagat ggaagacttg catcagttgc ttaaactttc   2460

agaaaatttg tagagaaacc caacaaatct cataaatgtg gaataacatt tgttcaaaaa   2520

tgatagctta gaaaacacta gagttcatac taaaagatat tttgcaaata cactaaatgg   2580

gaaaaataag caaggacacg ttcagaaatg acactgaatc cctgtgttga gtctacagag   2640

acatctagac ttaaaataga tcatttatat ttaagtttaa aaggaggatg agactgagtt   2700

tttgtagagt tataattaca ttcaaaatat acttttttgc attgaaaaaa tgttaaattt   2760

ttgaaaagcg aatattgatg tcattctatt ctcaaatcag tagatgctgt gtcttcattt   2820

ctagtgctga tgtgaaaaca catggtcagt tgttgctgcg tcagagatat gagaaattct   2880

tttctcttag gtgtgcatca ctgatatact tgtccgtgaa aggtgaaaga cactgaaatg   2940

taagatgcgt gagtaaaatc ttggtagaga ggc                                2973


<210>  2643
<211>  633
<212>  PRT
<213>  Homo sapiens

<400>  2643


Met Ala Gly Ala Gln Thr Leu Leu Thr Phe Arg Asp Val Ala Ile Glu 
1               5                   10                  15      


Phe Ser Leu Glu Glu Trp Lys Cys Leu Asp Leu Ala Gln Gln Asn Leu 
            20                  25                  30          


Tyr Arg Asp Val Met Leu Glu Asn Tyr Arg Asn Leu Phe Ser Val Gly 
        35                  40                  45              


Leu Thr Val Cys Lys Pro Gly Leu Ile Thr Cys Leu Glu Gln Arg Lys 
    50                  55                  60                  


Glu Pro Trp Asn Val Lys Arg Gln Glu Ala Ala Asp Gly His Pro Glu 
65                  70                  75                  80  


Met Gly Phe His His Ala Thr Gln Ala Cys Leu Glu Leu Leu Gly Ser 
                85                  90                  95      


Ser Asp Leu Pro Ala Ser Ala Ser Gln Ser Ala Gly Ile Thr Gly Val 
            100                 105                 110         


Asn His Arg Ala Gln Pro Gly Leu Asn Val Ser Val Asp Lys Phe Thr 
        115                 120                 125             


Ala Leu Cys Ser Pro Gly Val Leu Gln Thr Val Lys Trp Phe Leu Glu 
    130                 135                 140                 


Phe Arg Cys Ile Phe Ser Leu Ala Met Ser Ser His Phe Thr Gln Asp 
145                 150                 155                 160 


Leu Leu Pro Glu Gln Gly Ile Gln Asp Ala Phe Pro Lys Arg Ile Leu 
                165                 170                 175     


Arg Gly Tyr Gly Asn Cys Gly Leu Asp Asn Leu Tyr Leu Arg Lys Asp 
            180                 185                 190         


Trp Glu Ser Leu Asp Glu Cys Lys Leu Gln Lys Asp Tyr Asn Gly Leu 
        195                 200                 205             


Asn Gln Cys Ser Ser Thr Thr His Ser Lys Ile Phe Gln Tyr Asn Lys 
    210                 215                 220                 


Tyr Val Lys Ile Phe Asp Asn Phe Ser Asn Leu His Arg Arg Asn Ile 
225                 230                 235                 240 


Ser Asn Thr Gly Glu Lys Pro Phe Lys Cys Gln Glu Cys Gly Lys Ser 
                245                 250                 255     


Phe Gln Met Leu Ser Phe Leu Thr Glu His Gln Lys Ile His Thr Gly 
            260                 265                 270         


Lys Lys Phe Gln Lys Cys Gly Glu Cys Gly Lys Thr Phe Ile Gln Cys 
        275                 280                 285             


Ser His Phe Thr Glu Pro Glu Asn Ile Asp Thr Gly Glu Lys Pro Tyr 
    290                 295                 300                 


Lys Cys Gln Glu Cys Asn Asn Val Ile Lys Thr Cys Ser Val Leu Thr 
305                 310                 315                 320 


Lys Asn Arg Ile Tyr Ala Gly Gly Glu His Tyr Arg Cys Glu Glu Phe 
                325                 330                 335     


Gly Lys Val Phe Asn Gln Cys Ser His Leu Thr Glu His Glu His Gly 
            340                 345                 350         


Thr Glu Glu Lys Pro Cys Lys Tyr Glu Glu Cys Ser Ser Val Phe Ile 
        355                 360                 365             


Ser Cys Ser Ser Leu Ser Asn Gln Gln Met Ile Leu Ala Gly Glu Lys 
    370                 375                 380                 


Leu Ser Lys Cys Glu Thr Trp Tyr Lys Gly Phe Asn His Ser Pro Asn 
385                 390                 395                 400 


Pro Ser Lys His Gln Arg Asn Glu Ile Gly Gly Lys Pro Phe Lys Cys 
                405                 410                 415     


Glu Glu Cys Asp Ser Ile Phe Lys Trp Phe Ser Asp Leu Thr Lys His 
            420                 425                 430         


Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly 
        435                 440                 445             


Lys Ala Tyr Thr Gln Ser Ser His Leu Ser Glu His Arg Arg Ile His 
    450                 455                 460                 


Thr Gly Glu Lys Pro Tyr Gln Cys Glu Glu Cys Gly Lys Val Phe Arg 
465                 470                 475                 480 


Thr Cys Ser Ser Leu Ser Asn His Lys Arg Thr His Ser Glu Glu Lys 
                485                 490                 495     


Pro Tyr Thr Cys Glu Glu Cys Gly Asn Ile Phe Lys Gln Leu Ser Asp 
            500                 505                 510         


Leu Thr Lys His Lys Lys Thr His Thr Gly Glu Lys Pro Tyr Lys Cys 
        515                 520                 525             


Asp Glu Cys Gly Lys Asn Phe Thr Gln Ser Ser Asn Leu Ile Val His 
    530                 535                 540                 


Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly 
545                 550                 555                 560 


Arg Val Phe Met Trp Phe Ser Asp Ile Thr Lys His Lys Lys Thr His 
                565                 570                 575     


Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly Lys Asn Phe Thr 
            580                 585                 590         


Gln Ser Ser Asn Leu Ile Val His Lys Arg Ile His Thr Gly Glu Lys 
        595                 600                 605             


Pro Tyr Lys Cys Glu Lys Cys Gly Lys Ala Phe Thr Gln Phe Ser His 
    610                 615                 620                 


Leu Thr Val His Glu Ser Ile His Thr 
625                 630             

<210>  2644
<211>  3007
<212>  DNA
<213>  Homo sapiens

<400>  2644
ctgtccccgc ggctctgtgt cccctgctag ccgtaggtcg tgtgacccgc aggcaccggg     60

agatccagaa gtgaaacgcc aggctctctg gaggccagga gatggcacag acaccttacc    120

agaatgtctt tggtttgagg ttccactttg gaaacttgac agggtgattt gctctcagcc    180

accctctgga ctttttcctc agtttcagta ttgtccaggg ataacacagg atgcccacca    240

tggccatgtc tgctggagca tctagtgaat ttcaggccct gggttatttc tcagaggaca    300

gcctgaggta tgaagtgtgg cctctccagg gagcagctgg atgccctggg ctgagagaaa    360

tctcctggtc tactcttcct ctaaagagac tctgttgacg ttcagggatg tggccataga    420

attctccctg gaggagtgga aatgcctgga cctcgctcag cagaatttgt acagggatgt    480

gatgttggag aactacagaa acttgttctc cgttggtctc actgtctgta agccaggcct    540

gatcacctgc ctggagcaac gaaaagagcc ctggaatgtg aagagacagg aggcagcaga    600

cggacatcca gagatgggat ttcaccatgc tactcaggct tgtcttgaac tcctgggctc    660

aagcgatctg cctgcctcag cctcccaaag tgctgggatt acaggtgtga accaccgtgc    720

ccagccaggc ctcaatgttt ctgtggacaa attcactgca ctgtgctcac ctggggtgct    780

gcaaactgtg aaatggtttt tagagttcag atgcatcttc tcactagcta tgtcttctca    840

ttttacccaa gaccttctgc cagagcaggg catacaagat gcattcccaa aaagaatact    900

gagaggatat ggaaattgtg gccttgataa tttatattta aggaaagact gggaaagttt    960

agatgagtgt aagttgcaaa aagattataa tggacttaac caatgttcat caactaccca   1020

tagcaaaatc tttcaatata ataaatatgt taaaatcttt gataactttt caaatttaca   1080

tagacgtaat ataagtaata ctggagagaa acctttcaaa tgtcaagaat gtggcaaatc   1140

ctttcaaatg ctctcattcc taactgaaca tcagaaaatt cacactggaa aaaaattcca   1200

aaaatgtgga gaatgtggca aaacctttat ccagtgctca cactttactg aacctgagaa   1260

cattgacact ggagagaaac cttacaagtg tcaagaatgt aacaacgtca ttaaaacttg   1320

ctcagtcctt actaaaaata gaatttatgc cggaggggaa cattacagat gtgaagaatt   1380

tggcaaagta tttaaccagt gctcccacct tactgaacat gagcatggta ctgaggaaaa   1440

accctgcaaa tatgaagagt gcagcagtgt ctttatctct tgctcaagcc tttctaatca   1500

acagatgatt cttgctggag agaagctctc caaatgtgaa acatggtaca aaggttttaa   1560

ccacagccca aatccttcca aacaccagag aaatgagatt ggagggaaac ctttcaaatg   1620

tgaggaatgt gacagcatct tcaagtggtt ctcagacctt actaaacata agagaattca   1680

cactggtgag aaaccataca aatgtgacga atgtgggaaa gcctatacac agtcctcaca   1740

cctcagtgaa cacaggagga ttcacaccgg agagaaaccc taccaatgtg aagaatgtgg   1800

gaaggtcttc agaacttgct caagcctttc taaccataag agaactcatt ctgaagaaaa   1860

accctacacg tgtgaagaat gtggcaacat ctttaagcag ttatcagacc tcactaagca   1920

taagaaaacc catactggag agaagcccta caaatgtgac gaatgtggaa aaaactttac   1980

ccagtcctcc aaccttattg tacataagag aattcatact ggagagaaac cctacaagtg   2040

tgaagaatgt ggcagagtct tcatgtggtt ctcagacatt accaaacata agaaaaccca   2100

tactggagag aaaccctaca aatgtgacga atgtggaaaa aactttaccc agtcctcaaa   2160

ccttattgta cataagagaa ttcatactgg agagaaaccc tacaagtgtg aaaagtgtgg   2220

caaagccttc acccagttct cacacctgac tgtacatgaa agcattcata cttgagaaaa   2280

aaataaacaa atataaaaat aggcaaagcc gttagtatct gctcgcatcc cactttacat   2340

cagagttcag acttaataaa gttatcataa atgtaattac tattgaaaga cctttcatga   2400

aatataagtc tccagagcac acaagagtat ttcttctgaa aaaaatgtta caattatact   2460

agatggaaga cttgcatcag ttgcttaaac tttcagaaaa tttgtagaga aacccaacaa   2520

atctcataaa tgtggaataa catttgttca aaaatgatag cttagaaaac actagagttc   2580

atactaaaag atattttgca aatacactaa atgggaaaaa taagcaagga cacgttcaga   2640

aatgacactg aatccctgtg ttgagtctac agagacatct agacttaaaa tagatcattt   2700

atatttaagt ttaaaaggag gatgagactg agtttttgta gagttataat tacattcaaa   2760

atatactttt ttgcattgaa aaaatgttaa atttttgaaa agcgaatatt gatgtcattc   2820

tattctcaaa tcagtagatg ctgtgtcttc atttctagtg ctgatgtgaa aacacatggt   2880

cagttgttgc tgcgtcagag atatgagaaa ttcttttctc ttaggtgtgc atcactgata   2940

tacttgtccg tgaaaggtga aagacactga aatgtaagat gcgtgagtaa aatcttggta   3000

gagaggc                                                             3007


<210>  2645
<211>  644
<212>  PRT
<213>  Homo sapiens

<400>  2645


Met Pro Trp Ala Glu Arg Asn Leu Leu Val Tyr Ser Ser Ser Lys Glu 
1               5                   10                  15      


Thr Leu Leu Thr Phe Arg Asp Val Ala Ile Glu Phe Ser Leu Glu Glu 
            20                  25                  30          


Trp Lys Cys Leu Asp Leu Ala Gln Gln Asn Leu Tyr Arg Asp Val Met 
        35                  40                  45              


Leu Glu Asn Tyr Arg Asn Leu Phe Ser Val Gly Leu Thr Val Cys Lys 
    50                  55                  60                  


Pro Gly Leu Ile Thr Cys Leu Glu Gln Arg Lys Glu Pro Trp Asn Val 
65                  70                  75                  80  


Lys Arg Gln Glu Ala Ala Asp Gly His Pro Glu Met Gly Phe His His 
                85                  90                  95      


Ala Thr Gln Ala Cys Leu Glu Leu Leu Gly Ser Ser Asp Leu Pro Ala 
            100                 105                 110         


Ser Ala Ser Gln Ser Ala Gly Ile Thr Gly Val Asn His Arg Ala Gln 
        115                 120                 125             


Pro Gly Leu Asn Val Ser Val Asp Lys Phe Thr Ala Leu Cys Ser Pro 
    130                 135                 140                 


Gly Val Leu Gln Thr Val Lys Trp Phe Leu Glu Phe Arg Cys Ile Phe 
145                 150                 155                 160 


Ser Leu Ala Met Ser Ser His Phe Thr Gln Asp Leu Leu Pro Glu Gln 
                165                 170                 175     


Gly Ile Gln Asp Ala Phe Pro Lys Arg Ile Leu Arg Gly Tyr Gly Asn 
            180                 185                 190         


Cys Gly Leu Asp Asn Leu Tyr Leu Arg Lys Asp Trp Glu Ser Leu Asp 
        195                 200                 205             


Glu Cys Lys Leu Gln Lys Asp Tyr Asn Gly Leu Asn Gln Cys Ser Ser 
    210                 215                 220                 


Thr Thr His Ser Lys Ile Phe Gln Tyr Asn Lys Tyr Val Lys Ile Phe 
225                 230                 235                 240 


Asp Asn Phe Ser Asn Leu His Arg Arg Asn Ile Ser Asn Thr Gly Glu 
                245                 250                 255     


Lys Pro Phe Lys Cys Gln Glu Cys Gly Lys Ser Phe Gln Met Leu Ser 
            260                 265                 270         


Phe Leu Thr Glu His Gln Lys Ile His Thr Gly Lys Lys Phe Gln Lys 
        275                 280                 285             


Cys Gly Glu Cys Gly Lys Thr Phe Ile Gln Cys Ser His Phe Thr Glu 
    290                 295                 300                 


Pro Glu Asn Ile Asp Thr Gly Glu Lys Pro Tyr Lys Cys Gln Glu Cys 
305                 310                 315                 320 


Asn Asn Val Ile Lys Thr Cys Ser Val Leu Thr Lys Asn Arg Ile Tyr 
                325                 330                 335     


Ala Gly Gly Glu His Tyr Arg Cys Glu Glu Phe Gly Lys Val Phe Asn 
            340                 345                 350         


Gln Cys Ser His Leu Thr Glu His Glu His Gly Thr Glu Glu Lys Pro 
        355                 360                 365             


Cys Lys Tyr Glu Glu Cys Ser Ser Val Phe Ile Ser Cys Ser Ser Leu 
    370                 375                 380                 


Ser Asn Gln Gln Met Ile Leu Ala Gly Glu Lys Leu Ser Lys Cys Glu 
385                 390                 395                 400 


Thr Trp Tyr Lys Gly Phe Asn His Ser Pro Asn Pro Ser Lys His Gln 
                405                 410                 415     


Arg Asn Glu Ile Gly Gly Lys Pro Phe Lys Cys Glu Glu Cys Asp Ser 
            420                 425                 430         


Ile Phe Lys Trp Phe Ser Asp Leu Thr Lys His Lys Arg Ile His Thr 
        435                 440                 445             


Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly Lys Ala Tyr Thr Gln 
    450                 455                 460                 


Ser Ser His Leu Ser Glu His Arg Arg Ile His Thr Gly Glu Lys Pro 
465                 470                 475                 480 


Tyr Gln Cys Glu Glu Cys Gly Lys Val Phe Arg Thr Cys Ser Ser Leu 
                485                 490                 495     


Ser Asn His Lys Arg Thr His Ser Glu Glu Lys Pro Tyr Thr Cys Glu 
            500                 505                 510         


Glu Cys Gly Asn Ile Phe Lys Gln Leu Ser Asp Leu Thr Lys His Lys 
        515                 520                 525             


Lys Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly Lys 
    530                 535                 540                 


Asn Phe Thr Gln Ser Ser Asn Leu Ile Val His Lys Arg Ile His Thr 
545                 550                 555                 560 


Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Arg Val Phe Met Trp 
                565                 570                 575     


Phe Ser Asp Ile Thr Lys His Lys Lys Thr His Thr Gly Glu Lys Pro 
            580                 585                 590         


Tyr Lys Cys Asp Glu Cys Gly Lys Asn Phe Thr Gln Ser Ser Asn Leu 
        595                 600                 605             


Ile Val His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu 
    610                 615                 620                 


Lys Cys Gly Lys Ala Phe Thr Gln Phe Ser His Leu Thr Val His Glu 
625                 630                 635                 640 


Ser Ile His Thr 
                

<210>  2646
<211>  2982
<212>  DNA
<213>  Homo sapiens

<400>  2646
agagctccac ttcctgtccc cgcggctctg tgtcccctgc tagccgtagg tcgtgtgacc     60

cgcaggcacc gggagatcca gaagtgaaac gccaggctct ctggaggcca ggagatgcca    120

ttaggaaaac agagaaggca gccatggtcc ccgcaagcca gaaacttttc catttccagt    180

aactggataa atcattgaat tcagcgtctt ggggtcagca tgaagaaggg agtggtcaaa    240

gggacttctg cttcatttgg gccattttcc tgatgtggtt gttgtgtgat ttgtccagag    300

aatctttcct aagaggaaat cccagagaag caggagaaag agaaagaaat ggctggtgct    360

cagactctgt tgacgttcag ggatgtggcc atagaattct ccctggagga gtggaaatgc    420

ctggacctcg ctcagcagaa tttgtacagg gatgtgatgt tggagaacta cagaaacttg    480

ttctccgttg gtctcactgt ctgtaagcca ggcctgatca cctgcctgga gcaacgaaaa    540

gagccctgga atgtgaagag acaggaggca gcagacggac atccagagat gggatttcac    600

catgctactc aggcttgtct tgaactcctg ggctcaagcg atctgcctgc ctcagcctcc    660

caaagtgctg ggattacagg tgtgaaccac cgtgcccagc caggcctcaa tgtttctgtg    720

gacaaattca ctgcactgtg ctcacctggg gtgctgcaaa ctgtgaaatg gtttttagag    780

ttcagatgca tcttctcact agctatgtct tctcatttta cccaagacct tctgccagag    840

cagggcatac aagatgcatt cccaaaaaga atactgagag gatatggaaa ttgtggcctt    900

gataatttat atttaaggaa agactgggaa agtttagatg agtgtaagtt gcaaaaagat    960

tataatggac ttaaccaatg ttcatcaact acccatagca aaatctttca atataataaa   1020

tatgttaaaa tctttgataa cttttcaaat ttacatagac gtaatataag taatactgga   1080

gagaaacctt tcaaatgtca agaatgtggc aaatcctttc aaatgctctc attcctaact   1140

gaacatcaga aaattcacac tggaaaaaaa ttccaaaaat gtggagaatg tggcaaaacc   1200

tttatccagt gctcacactt tactgaacct gagaacattg acactggaga gaaaccttac   1260

aagtgtcaag aatgtaacaa cgtcattaaa acttgctcag tccttactaa aaatagaatt   1320

tatgccggag gggaacatta cagatgtgaa gaatttggca aagtatttaa ccagtgctcc   1380

caccttactg aacatgagca tggtactgag gaaaaaccct gcaaatatga agagtgcagc   1440

agtgtcttta tctcttgctc aagcctttct aatcaacaga tgattcttgc tggagagaag   1500

ctctccaaat gtgaaacatg gtacaaaggt tttaaccaca gcccaaatcc ttccaaacac   1560

cagagaaatg agattggagg gaaacctttc aaatgtgagg aatgtgacag catcttcaag   1620

tggttctcag accttactaa acataagaga attcacactg gtgagaaacc atacaaatgt   1680

gacgaatgtg ggaaagccta tacacagtcc tcacacctca gtgaacacag gaggattcac   1740

accggagaga aaccctacca atgtgaagaa tgtgggaagg tcttcagaac ttgctcaagc   1800

ctttctaacc ataagagaac tcattctgaa gaaaaaccct acacgtgtga agaatgtggc   1860

aacatcttta agcagttatc agacctcact aagcataaga aaacccatac tggagagaag   1920

ccctacaaat gtgacgaatg tggaaaaaac tttacccagt cctccaacct tattgtacat   1980

aagagaattc atactggaga gaaaccctac aagtgtgaag aatgtggcag agtcttcatg   2040

tggttctcag acattaccaa acataagaaa acccatactg gagagaaacc ctacaaatgt   2100

gacgaatgtg gaaaaaactt tacccagtcc tcaaacctta ttgtacataa gagaattcat   2160

actggagaga aaccctacaa gtgtgaaaag tgtggcaaag ccttcaccca gttctcacac   2220

ctgactgtac atgaaagcat tcatacttga gaaaaaaata aacaaatata aaaataggca   2280

aagccgttag tatctgctcg catcccactt tacatcagag ttcagactta ataaagttat   2340

cataaatgta attactattg aaagaccttt catgaaatat aagtctccag agcacacaag   2400

agtatttctt ctgaaaaaaa tgttacaatt atactagatg gaagacttgc atcagttgct   2460

taaactttca gaaaatttgt agagaaaccc aacaaatctc ataaatgtgg aataacattt   2520

gttcaaaaat gatagcttag aaaacactag agttcatact aaaagatatt ttgcaaatac   2580

actaaatggg aaaaataagc aaggacacgt tcagaaatga cactgaatcc ctgtgttgag   2640

tctacagaga catctagact taaaatagat catttatatt taagtttaaa aggaggatga   2700

gactgagttt ttgtagagtt ataattacat tcaaaatata cttttttgca ttgaaaaaat   2760

gttaaatttt tgaaaagcga atattgatgt cattctattc tcaaatcagt agatgctgtg   2820

tcttcatttc tagtgctgat gtgaaaacac atggtcagtt gttgctgcgt cagagatatg   2880

agaaattctt ttctcttagg tgtgcatcac tgatatactt gtccgtgaaa ggtgaaagac   2940

actgaaatgt aagatgcgtg agtaaaatct tggtagagag gc                      2982


<210>  2647
<211>  633
<212>  PRT
<213>  Homo sapiens

<400>  2647


Met Ala Gly Ala Gln Thr Leu Leu Thr Phe Arg Asp Val Ala Ile Glu 
1               5                   10                  15      


Phe Ser Leu Glu Glu Trp Lys Cys Leu Asp Leu Ala Gln Gln Asn Leu 
            20                  25                  30          


Tyr Arg Asp Val Met Leu Glu Asn Tyr Arg Asn Leu Phe Ser Val Gly 
        35                  40                  45              


Leu Thr Val Cys Lys Pro Gly Leu Ile Thr Cys Leu Glu Gln Arg Lys 
    50                  55                  60                  


Glu Pro Trp Asn Val Lys Arg Gln Glu Ala Ala Asp Gly His Pro Glu 
65                  70                  75                  80  


Met Gly Phe His His Ala Thr Gln Ala Cys Leu Glu Leu Leu Gly Ser 
                85                  90                  95      


Ser Asp Leu Pro Ala Ser Ala Ser Gln Ser Ala Gly Ile Thr Gly Val 
            100                 105                 110         


Asn His Arg Ala Gln Pro Gly Leu Asn Val Ser Val Asp Lys Phe Thr 
        115                 120                 125             


Ala Leu Cys Ser Pro Gly Val Leu Gln Thr Val Lys Trp Phe Leu Glu 
    130                 135                 140                 


Phe Arg Cys Ile Phe Ser Leu Ala Met Ser Ser His Phe Thr Gln Asp 
145                 150                 155                 160 


Leu Leu Pro Glu Gln Gly Ile Gln Asp Ala Phe Pro Lys Arg Ile Leu 
                165                 170                 175     


Arg Gly Tyr Gly Asn Cys Gly Leu Asp Asn Leu Tyr Leu Arg Lys Asp 
            180                 185                 190         


Trp Glu Ser Leu Asp Glu Cys Lys Leu Gln Lys Asp Tyr Asn Gly Leu 
        195                 200                 205             


Asn Gln Cys Ser Ser Thr Thr His Ser Lys Ile Phe Gln Tyr Asn Lys 
    210                 215                 220                 


Tyr Val Lys Ile Phe Asp Asn Phe Ser Asn Leu His Arg Arg Asn Ile 
225                 230                 235                 240 


Ser Asn Thr Gly Glu Lys Pro Phe Lys Cys Gln Glu Cys Gly Lys Ser 
                245                 250                 255     


Phe Gln Met Leu Ser Phe Leu Thr Glu His Gln Lys Ile His Thr Gly 
            260                 265                 270         


Lys Lys Phe Gln Lys Cys Gly Glu Cys Gly Lys Thr Phe Ile Gln Cys 
        275                 280                 285             


Ser His Phe Thr Glu Pro Glu Asn Ile Asp Thr Gly Glu Lys Pro Tyr 
    290                 295                 300                 


Lys Cys Gln Glu Cys Asn Asn Val Ile Lys Thr Cys Ser Val Leu Thr 
305                 310                 315                 320 


Lys Asn Arg Ile Tyr Ala Gly Gly Glu His Tyr Arg Cys Glu Glu Phe 
                325                 330                 335     


Gly Lys Val Phe Asn Gln Cys Ser His Leu Thr Glu His Glu His Gly 
            340                 345                 350         


Thr Glu Glu Lys Pro Cys Lys Tyr Glu Glu Cys Ser Ser Val Phe Ile 
        355                 360                 365             


Ser Cys Ser Ser Leu Ser Asn Gln Gln Met Ile Leu Ala Gly Glu Lys 
    370                 375                 380                 


Leu Ser Lys Cys Glu Thr Trp Tyr Lys Gly Phe Asn His Ser Pro Asn 
385                 390                 395                 400 


Pro Ser Lys His Gln Arg Asn Glu Ile Gly Gly Lys Pro Phe Lys Cys 
                405                 410                 415     


Glu Glu Cys Asp Ser Ile Phe Lys Trp Phe Ser Asp Leu Thr Lys His 
            420                 425                 430         


Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly 
        435                 440                 445             


Lys Ala Tyr Thr Gln Ser Ser His Leu Ser Glu His Arg Arg Ile His 
    450                 455                 460                 


Thr Gly Glu Lys Pro Tyr Gln Cys Glu Glu Cys Gly Lys Val Phe Arg 
465                 470                 475                 480 


Thr Cys Ser Ser Leu Ser Asn His Lys Arg Thr His Ser Glu Glu Lys 
                485                 490                 495     


Pro Tyr Thr Cys Glu Glu Cys Gly Asn Ile Phe Lys Gln Leu Ser Asp 
            500                 505                 510         


Leu Thr Lys His Lys Lys Thr His Thr Gly Glu Lys Pro Tyr Lys Cys 
        515                 520                 525             


Asp Glu Cys Gly Lys Asn Phe Thr Gln Ser Ser Asn Leu Ile Val His 
    530                 535                 540                 


Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly 
545                 550                 555                 560 


Arg Val Phe Met Trp Phe Ser Asp Ile Thr Lys His Lys Lys Thr His 
                565                 570                 575     


Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly Lys Asn Phe Thr 
            580                 585                 590         


Gln Ser Ser Asn Leu Ile Val His Lys Arg Ile His Thr Gly Glu Lys 
        595                 600                 605             


Pro Tyr Lys Cys Glu Lys Cys Gly Lys Ala Phe Thr Gln Phe Ser His 
    610                 615                 620                 


Leu Thr Val His Glu Ser Ile His Thr 
625                 630             

<210>  2648
<211>  2745
<212>  DNA
<213>  Homo sapiens

<400>  2648
gtcccgacag agctccactt cctgtccccg cggctctgtg tcccctgcta gccgtaggtc     60

gtgtgacccg caggcaccgg gagatccaga agtgaaacgc caggctctct ggaggccagg    120

agatgactct gttgacgttc agggatgtgg ccatagaatt ctccctggag gagtggaaat    180

gcctggacct cgctcagcag aatttgtaca gggatgtgat gttggagaac tacagaaact    240

tgttctccgt tggtctcact gtctgtaagc caggcctgat cacctgcctg gagcaacgaa    300

aagagccctg gaatgtgaag agacaggagg cagcagacgg acatccaggt attttctttg    360

tggttaccat ggaaattata taaaacatct taaagttaca acaaggtatt ttacactgag    420

atgggatttc accatgctac tcaggcttgt cttgaactcc tgggctcaag cgatctgcct    480

gcctcagcct cccaaagtgc tgggattaca ggtgtgaacc accgtgccca gccaggcctc    540

aatgtttctg tggacaaatt cactgctatg tcttctcatt ttacccaaga ccttctgcca    600

gagcagggca tacaagatgc attcccaaaa agaatactga gaggatatgg aaattgtggc    660

cttgataatt tatatttaag gaaagactgg gaaagtttag atgagtgtaa gttgcaaaaa    720

gattataatg gacttaacca atgttcatca actacccata gcaaaatctt tcaatataat    780

aaatatgtta aaatctttga taacttttca aatttacata gacgtaatat aagtaatact    840

ggagagaaac ctttcaaatg tcaagaatgt ggcaaatcct ttcaaatgct ctcattccta    900

actgaacatc agaaaattca cactggaaaa aaattccaaa aatgtggaga atgtggcaaa    960

acctttatcc agtgctcaca ctttactgaa cctgagaaca ttgacactgg agagaaacct   1020

tacaagtgtc aagaatgtaa caacgtcatt aaaacttgct cagtccttac taaaaataga   1080

atttatgccg gaggggaaca ttacagatgt gaagaatttg gcaaagtatt taaccagtgc   1140

tcccacctta ctgaacatga gcatggtact gaggaaaaac cctgcaaata tgaagagtgc   1200

agcagtgtct ttatctcttg ctcaagcctt tctaatcaac agatgattct tgctggagag   1260

aagctctcca aatgtgaaac atggtacaaa ggttttaacc acagcccaaa tccttccaaa   1320

caccagagaa atgagattgg agggaaacct ttcaaatgtg aggaatgtga cagcatcttc   1380

aagtggttct cagaccttac taaacataag agaattcaca ctggtgagaa accatacaaa   1440

tgtgacgaat gtgggaaagc ctatacacag tcctcacacc tcagtgaaca caggaggatt   1500

cacaccggag agaaacccta ccaatgtgaa gaatgtggga aggtcttcag aacttgctca   1560

agcctttcta accataagag aactcattct gaagaaaaac cctacacgtg tgaagaatgt   1620

ggcaacatct ttaagcagtt atcagacctc actaagcata agaaaaccca tactggagag   1680

aagccctaca aatgtgacga atgtggaaaa aactttaccc agtcctccaa ccttattgta   1740

cataagagaa ttcatactgg agagaaaccc tacaagtgtg aagaatgtgg cagagtcttc   1800

atgtggttct cagacattac caaacataag aaaacccata ctggagagaa accctacaaa   1860

tgtgacgaat gtggaaaaaa ctttacccag tcctcaaacc ttattgtaca taagagaatt   1920

catactggag agaaacccta caagtgtgaa aagtgtggca aagccttcac ccagttctca   1980

cacctgactg tacatgaaag cattcatact tgagaaaaaa ataaacaaat ataaaaatag   2040

gcaaagccgt tagtatctgc tcgcatccca ctttacatca gagttcagac ttaataaagt   2100

tatcataaat gtaattacta ttgaaagacc tttcatgaaa tataagtctc cagagcacac   2160

aagagtattt cttctgaaaa aaatgttaca attatactag atggaagact tgcatcagtt   2220

gcttaaactt tcagaaaatt tgtagagaaa cccaacaaat ctcataaatg tggaataaca   2280

tttgttcaaa aatgatagct tagaaaacac tagagttcat actaaaagat attttgcaaa   2340

tacactaaat gggaaaaata agcaaggaca cgttcagaaa tgacactgaa tccctgtgtt   2400

gagtctacag agacatctag acttaaaata gatcatttat atttaagttt aaaaggagga   2460

tgagactgag tttttgtaga gttataatta cattcaaaat atactttttt gcattgaaaa   2520

aatgttaaat ttttgaaaag cgaatattga tgtcattcta ttctcaaatc agtagatgct   2580

gtgtcttcat ttctagtgct gatgtgaaaa cacatggtca gttgttgctg cgtcagagat   2640

atgagaaatt cttttctctt aggtgtgcat cactgatata cttgtccgtg aaaggtgaaa   2700

gacactgaaa tgtaagatgc gtgagtaaaa tcttggtaga gaggc                   2745


<210>  2649
<211>  530
<212>  PRT
<213>  Homo sapiens

<400>  2649


Met Gly Phe His His Ala Thr Gln Ala Cys Leu Glu Leu Leu Gly Ser 
1               5                   10                  15      


Ser Asp Leu Pro Ala Ser Ala Ser Gln Ser Ala Gly Ile Thr Gly Val 
            20                  25                  30          


Asn His Arg Ala Gln Pro Gly Leu Asn Val Ser Val Asp Lys Phe Thr 
        35                  40                  45              


Ala Met Ser Ser His Phe Thr Gln Asp Leu Leu Pro Glu Gln Gly Ile 
    50                  55                  60                  


Gln Asp Ala Phe Pro Lys Arg Ile Leu Arg Gly Tyr Gly Asn Cys Gly 
65                  70                  75                  80  


Leu Asp Asn Leu Tyr Leu Arg Lys Asp Trp Glu Ser Leu Asp Glu Cys 
                85                  90                  95      


Lys Leu Gln Lys Asp Tyr Asn Gly Leu Asn Gln Cys Ser Ser Thr Thr 
            100                 105                 110         


His Ser Lys Ile Phe Gln Tyr Asn Lys Tyr Val Lys Ile Phe Asp Asn 
        115                 120                 125             


Phe Ser Asn Leu His Arg Arg Asn Ile Ser Asn Thr Gly Glu Lys Pro 
    130                 135                 140                 


Phe Lys Cys Gln Glu Cys Gly Lys Ser Phe Gln Met Leu Ser Phe Leu 
145                 150                 155                 160 


Thr Glu His Gln Lys Ile His Thr Gly Lys Lys Phe Gln Lys Cys Gly 
                165                 170                 175     


Glu Cys Gly Lys Thr Phe Ile Gln Cys Ser His Phe Thr Glu Pro Glu 
            180                 185                 190         


Asn Ile Asp Thr Gly Glu Lys Pro Tyr Lys Cys Gln Glu Cys Asn Asn 
        195                 200                 205             


Val Ile Lys Thr Cys Ser Val Leu Thr Lys Asn Arg Ile Tyr Ala Gly 
    210                 215                 220                 


Gly Glu His Tyr Arg Cys Glu Glu Phe Gly Lys Val Phe Asn Gln Cys 
225                 230                 235                 240 


Ser His Leu Thr Glu His Glu His Gly Thr Glu Glu Lys Pro Cys Lys 
                245                 250                 255     


Tyr Glu Glu Cys Ser Ser Val Phe Ile Ser Cys Ser Ser Leu Ser Asn 
            260                 265                 270         


Gln Gln Met Ile Leu Ala Gly Glu Lys Leu Ser Lys Cys Glu Thr Trp 
        275                 280                 285             


Tyr Lys Gly Phe Asn His Ser Pro Asn Pro Ser Lys His Gln Arg Asn 
    290                 295                 300                 


Glu Ile Gly Gly Lys Pro Phe Lys Cys Glu Glu Cys Asp Ser Ile Phe 
305                 310                 315                 320 


Lys Trp Phe Ser Asp Leu Thr Lys His Lys Arg Ile His Thr Gly Glu 
                325                 330                 335     


Lys Pro Tyr Lys Cys Asp Glu Cys Gly Lys Ala Tyr Thr Gln Ser Ser 
            340                 345                 350         


His Leu Ser Glu His Arg Arg Ile His Thr Gly Glu Lys Pro Tyr Gln 
        355                 360                 365             


Cys Glu Glu Cys Gly Lys Val Phe Arg Thr Cys Ser Ser Leu Ser Asn 
    370                 375                 380                 


His Lys Arg Thr His Ser Glu Glu Lys Pro Tyr Thr Cys Glu Glu Cys 
385                 390                 395                 400 


Gly Asn Ile Phe Lys Gln Leu Ser Asp Leu Thr Lys His Lys Lys Thr 
                405                 410                 415     


His Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly Lys Asn Phe 
            420                 425                 430         


Thr Gln Ser Ser Asn Leu Ile Val His Lys Arg Ile His Thr Gly Glu 
        435                 440                 445             


Lys Pro Tyr Lys Cys Glu Glu Cys Gly Arg Val Phe Met Trp Phe Ser 
    450                 455                 460                 


Asp Ile Thr Lys His Lys Lys Thr His Thr Gly Glu Lys Pro Tyr Lys 
465                 470                 475                 480 


Cys Asp Glu Cys Gly Lys Asn Phe Thr Gln Ser Ser Asn Leu Ile Val 
                485                 490                 495     


His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Lys Cys 
            500                 505                 510         


Gly Lys Ala Phe Thr Gln Phe Ser His Leu Thr Val His Glu Ser Ile 
        515                 520                 525             


His Thr 
    530 

<210>  2650
<211>  2528
<212>  DNA
<213>  Homo sapiens

<400>  2650
gtcccgacag agctccactt cctgtccccg cggctctgtg tcccctgcta gccgtaggtc     60

gtgtgacccg caggcaccgg gagatccaga agtgaaacgc caggctctct ggaggccagg    120

agatgactct gttgacgttc agggatgtgg ccatagaatt ctccctggag gagtggaaat    180

gcctggacct cgctcagcag aatttgtaca gggatgtgat gttggagaac tacagaaact    240

tgttctccgt tggtctcact gtctgtaagc caggcctgat cacctgcctg gagcaacgaa    300

aagagccctg gaatgtgaag agacaggagg cagcagacgg acatccagct atgtcttctc    360

attttaccca agaccttctg ccagagcagg gcatacaaga tgcattccca aaaagaatac    420

tgagaggata tggaaattgt ggccttgata atttatattt aaggaaagac tgggaaagtt    480

tagatgagtg taagttgcaa aaagattata atggacttaa ccaatgttca tcaactaccc    540

atagcaaaat ctttcaatat aataaatatg ttaaaatctt tgataacttt tcaaatttac    600

atagacgtaa tataagtaat actggagaga aacctttcaa atgtcaagaa tgtggcaaat    660

cctttcaaat gctctcattc ctaactgaac atcagaaaat tcacactgga aaaaaattcc    720

aaaaatgtgg agaatgtggc aaaaccttta tccagtgctc acactttact gaacctgaga    780

acattgacac tggagagaaa ccttacaagt gtcaagaatg taacaacgtc attaaaactt    840

gctcagtcct tactaaaaat agaatttatg ccggagggga acattacaga tgtgaagaat    900

ttggcaaagt atttaaccag tgctcccacc ttactgaaca tgagcatggt actgaggaaa    960

aaccctgcaa atatgaagag tgcagcagtg tctttatctc ttgctcaagc ctttctaatc   1020

aacagatgat tcttgctgga gagaagctct ccaaatgtga aacatggtac aaaggtttta   1080

accacagccc aaatccttcc aaacaccaga gaaatgagat tggagggaaa cctttcaaat   1140

gtgaggaatg tgacagcatc ttcaagtggt tctcagacct tactaaacat aagagaattc   1200

acactggtga gaaaccatac aaatgtgacg aatgtgggaa agcctataca cagtcctcac   1260

acctcagtga acacaggagg attcacaccg gagagaaacc ctaccaatgt gaagaatgtg   1320

ggaaggtctt cagaacttgc tcaagccttt ctaaccataa gagaactcat tctgaagaaa   1380

aaccctacac gtgtgaagaa tgtggcaaca tctttaagca gttatcagac ctcactaagc   1440

ataagaaaac ccatactgga gagaagccct acaaatgtga cgaatgtgga aaaaacttta   1500

cccagtcctc caaccttatt gtacataaga gaattcatac tggagagaaa ccctacaagt   1560

gtgaagaatg tggcagagtc ttcatgtggt tctcagacat taccaaacat aagaaaaccc   1620

atactggaga gaaaccctac aaatgtgacg aatgtggaaa aaactttacc cagtcctcaa   1680

accttattgt acataagaga attcatactg gagagaaacc ctacaagtgt gaaaagtgtg   1740

gcaaagcctt cacccagttc tcacacctga ctgtacatga aagcattcat acttgagaaa   1800

aaaataaaca aatataaaaa taggcaaagc cgttagtatc tgctcgcatc ccactttaca   1860

tcagagttca gacttaataa agttatcata aatgtaatta ctattgaaag acctttcatg   1920

aaatataagt ctccagagca cacaagagta tttcttctga aaaaaatgtt acaattatac   1980

tagatggaag acttgcatca gttgcttaaa ctttcagaaa atttgtagag aaacccaaca   2040

aatctcataa atgtggaata acatttgttc aaaaatgata gcttagaaaa cactagagtt   2100

catactaaaa gatattttgc aaatacacta aatgggaaaa ataagcaagg acacgttcag   2160

aaatgacact gaatccctgt gttgagtcta cagagacatc tagacttaaa atagatcatt   2220

tatatttaag tttaaaagga ggatgagact gagtttttgt agagttataa ttacattcaa   2280

aatatacttt tttgcattga aaaaatgtta aatttttgaa aagcgaatat tgatgtcatt   2340

ctattctcaa atcagtagat gctgtgtctt catttctagt gctgatgtga aaacacatgg   2400

tcagttgttg ctgcgtcaga gatatgagaa attcttttct cttaggtgtg catcactgat   2460

atacttgtcc gtgaaaggtg aaagacactg aaatgtaaga tgcgtgagta aaatcttggt   2520

agagaggc                                                            2528


<210>  2651
<211>  557
<212>  PRT
<213>  Homo sapiens

<400>  2651


Met Thr Leu Leu Thr Phe Arg Asp Val Ala Ile Glu Phe Ser Leu Glu 
1               5                   10                  15      


Glu Trp Lys Cys Leu Asp Leu Ala Gln Gln Asn Leu Tyr Arg Asp Val 
            20                  25                  30          


Met Leu Glu Asn Tyr Arg Asn Leu Phe Ser Val Gly Leu Thr Val Cys 
        35                  40                  45              


Lys Pro Gly Leu Ile Thr Cys Leu Glu Gln Arg Lys Glu Pro Trp Asn 
    50                  55                  60                  


Val Lys Arg Gln Glu Ala Ala Asp Gly His Pro Ala Met Ser Ser His 
65                  70                  75                  80  


Phe Thr Gln Asp Leu Leu Pro Glu Gln Gly Ile Gln Asp Ala Phe Pro 
                85                  90                  95      


Lys Arg Ile Leu Arg Gly Tyr Gly Asn Cys Gly Leu Asp Asn Leu Tyr 
            100                 105                 110         


Leu Arg Lys Asp Trp Glu Ser Leu Asp Glu Cys Lys Leu Gln Lys Asp 
        115                 120                 125             


Tyr Asn Gly Leu Asn Gln Cys Ser Ser Thr Thr His Ser Lys Ile Phe 
    130                 135                 140                 


Gln Tyr Asn Lys Tyr Val Lys Ile Phe Asp Asn Phe Ser Asn Leu His 
145                 150                 155                 160 


Arg Arg Asn Ile Ser Asn Thr Gly Glu Lys Pro Phe Lys Cys Gln Glu 
                165                 170                 175     


Cys Gly Lys Ser Phe Gln Met Leu Ser Phe Leu Thr Glu His Gln Lys 
            180                 185                 190         


Ile His Thr Gly Lys Lys Phe Gln Lys Cys Gly Glu Cys Gly Lys Thr 
        195                 200                 205             


Phe Ile Gln Cys Ser His Phe Thr Glu Pro Glu Asn Ile Asp Thr Gly 
    210                 215                 220                 


Glu Lys Pro Tyr Lys Cys Gln Glu Cys Asn Asn Val Ile Lys Thr Cys 
225                 230                 235                 240 


Ser Val Leu Thr Lys Asn Arg Ile Tyr Ala Gly Gly Glu His Tyr Arg 
                245                 250                 255     


Cys Glu Glu Phe Gly Lys Val Phe Asn Gln Cys Ser His Leu Thr Glu 
            260                 265                 270         


His Glu His Gly Thr Glu Glu Lys Pro Cys Lys Tyr Glu Glu Cys Ser 
        275                 280                 285             


Ser Val Phe Ile Ser Cys Ser Ser Leu Ser Asn Gln Gln Met Ile Leu 
    290                 295                 300                 


Ala Gly Glu Lys Leu Ser Lys Cys Glu Thr Trp Tyr Lys Gly Phe Asn 
305                 310                 315                 320 


His Ser Pro Asn Pro Ser Lys His Gln Arg Asn Glu Ile Gly Gly Lys 
                325                 330                 335     


Pro Phe Lys Cys Glu Glu Cys Asp Ser Ile Phe Lys Trp Phe Ser Asp 
            340                 345                 350         


Leu Thr Lys His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys 
        355                 360                 365             


Asp Glu Cys Gly Lys Ala Tyr Thr Gln Ser Ser His Leu Ser Glu His 
    370                 375                 380                 


Arg Arg Ile His Thr Gly Glu Lys Pro Tyr Gln Cys Glu Glu Cys Gly 
385                 390                 395                 400 


Lys Val Phe Arg Thr Cys Ser Ser Leu Ser Asn His Lys Arg Thr His 
                405                 410                 415     


Ser Glu Glu Lys Pro Tyr Thr Cys Glu Glu Cys Gly Asn Ile Phe Lys 
            420                 425                 430         


Gln Leu Ser Asp Leu Thr Lys His Lys Lys Thr His Thr Gly Glu Lys 
        435                 440                 445             


Pro Tyr Lys Cys Asp Glu Cys Gly Lys Asn Phe Thr Gln Ser Ser Asn 
    450                 455                 460                 


Leu Ile Val His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys 
465                 470                 475                 480 


Glu Glu Cys Gly Arg Val Phe Met Trp Phe Ser Asp Ile Thr Lys His 
                485                 490                 495     


Lys Lys Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly 
            500                 505                 510         


Lys Asn Phe Thr Gln Ser Ser Asn Leu Ile Val His Lys Arg Ile His 
        515                 520                 525             


Thr Gly Glu Lys Pro Tyr Lys Cys Glu Lys Cys Gly Lys Ala Phe Thr 
    530                 535                 540                 


Gln Phe Ser His Leu Thr Val His Glu Ser Ile His Thr 
545                 550                 555         

<210>  2652
<211>  2732
<212>  DNA
<213>  Homo sapiens

<400>  2652
gtcccgacag agctccactt cctgtccccg cggctctgtg tcccctgcta gccgtaggtc     60

gtgtgacccg caggcaccgg gagatccaga agtgaaacgc caggctctct ggaggccagg    120

agatgactct gttgacgttc agggatgtgg ccatagaatt ctccctggag gagtggaaat    180

gcctggacct cgctcagcag aatttgtaca gggatgtgat gttggagaac tacagaaact    240

tgttctccgt tggtctcact gtctgtaagc caggcctgat cacctgcctg gagcaacgaa    300

aagagccctg gaatgtgaag agacaggagg cagcagacgg acatccaggc tggaagtgca    360

gtggtgtgat cgtggctcac tgcggcctcc acttcccagg ttcagagatg ggatttcacc    420

atgctactca ggcttgtctt gaactcctgg gctcaagcga tctgcctgcc tcagcctccc    480

aaagtgctgg gattacaggt gtgaaccacc gtgcccagcc aggcctcaat gtttctgtgg    540

acaaattcac tgctatgtct tctcatttta cccaagacct tctgccagag cagggcatac    600

aagatgcatt cccaaaaaga atactgagag gatatggaaa ttgtggcctt gataatttat    660

atttaaggaa agactgggaa agtttagatg agtgtaagtt gcaaaaagat tataatggac    720

ttaaccaatg ttcatcaact acccatagca aaatctttca atataataaa tatgttaaaa    780

tctttgataa cttttcaaat ttacatagac gtaatataag taatactgga gagaaacctt    840

tcaaatgtca agaatgtggc aaatcctttc aaatgctctc attcctaact gaacatcaga    900

aaattcacac tggaaaaaaa ttccaaaaat gtggagaatg tggcaaaacc tttatccagt    960

gctcacactt tactgaacct gagaacattg acactggaga gaaaccttac aagtgtcaag   1020

aatgtaacaa cgtcattaaa acttgctcag tccttactaa aaatagaatt tatgccggag   1080

gggaacatta cagatgtgaa gaatttggca aagtatttaa ccagtgctcc caccttactg   1140

aacatgagca tggtactgag gaaaaaccct gcaaatatga agagtgcagc agtgtcttta   1200

tctcttgctc aagcctttct aatcaacaga tgattcttgc tggagagaag ctctccaaat   1260

gtgaaacatg gtacaaaggt tttaaccaca gcccaaatcc ttccaaacac cagagaaatg   1320

agattggagg gaaacctttc aaatgtgagg aatgtgacag catcttcaag tggttctcag   1380

accttactaa acataagaga attcacactg gtgagaaacc atacaaatgt gacgaatgtg   1440

ggaaagccta tacacagtcc tcacacctca gtgaacacag gaggattcac accggagaga   1500

aaccctacca atgtgaagaa tgtgggaagg tcttcagaac ttgctcaagc ctttctaacc   1560

ataagagaac tcattctgaa gaaaaaccct acacgtgtga agaatgtggc aacatcttta   1620

agcagttatc agacctcact aagcataaga aaacccatac tggagagaag ccctacaaat   1680

gtgacgaatg tggaaaaaac tttacccagt cctccaacct tattgtacat aagagaattc   1740

atactggaga gaaaccctac aagtgtgaag aatgtggcag agtcttcatg tggttctcag   1800

acattaccaa acataagaaa acccatactg gagagaaacc ctacaaatgt gacgaatgtg   1860

gaaaaaactt tacccagtcc tcaaacctta ttgtacataa gagaattcat actggagaga   1920

aaccctacaa gtgtgaaaag tgtggcaaag ccttcaccca gttctcacac ctgactgtac   1980

atgaaagcat tcatacttga gaaaaaaata aacaaatata aaaataggca aagccgttag   2040

tatctgctcg catcccactt tacatcagag ttcagactta ataaagttat cataaatgta   2100

attactattg aaagaccttt catgaaatat aagtctccag agcacacaag agtatttctt   2160

ctgaaaaaaa tgttacaatt atactagatg gaagacttgc atcagttgct taaactttca   2220

gaaaatttgt agagaaaccc aacaaatctc ataaatgtgg aataacattt gttcaaaaat   2280

gatagcttag aaaacactag agttcatact aaaagatatt ttgcaaatac actaaatggg   2340

aaaaataagc aaggacacgt tcagaaatga cactgaatcc ctgtgttgag tctacagaga   2400

catctagact taaaatagat catttatatt taagtttaaa aggaggatga gactgagttt   2460

ttgtagagtt ataattacat tcaaaatata cttttttgca ttgaaaaaat gttaaatttt   2520

tgaaaagcga atattgatgt cattctattc tcaaatcagt agatgctgtg tcttcatttc   2580

tagtgctgat gtgaaaacac atggtcagtt gttgctgcgt cagagatatg agaaattctt   2640

ttctcttagg tgtgcatcac tgatatactt gtccgtgaaa ggtgaaagac actgaaatgt   2700

aagatgcgtg agtaaaatct tggtagagag gc                                 2732


<210>  2653
<211>  625
<212>  PRT
<213>  Homo sapiens

<400>  2653


Met Thr Leu Leu Thr Phe Arg Asp Val Ala Ile Glu Phe Ser Leu Glu 
1               5                   10                  15      


Glu Trp Lys Cys Leu Asp Leu Ala Gln Gln Asn Leu Tyr Arg Asp Val 
            20                  25                  30          


Met Leu Glu Asn Tyr Arg Asn Leu Phe Ser Val Gly Leu Thr Val Cys 
        35                  40                  45              


Lys Pro Gly Leu Ile Thr Cys Leu Glu Gln Arg Lys Glu Pro Trp Asn 
    50                  55                  60                  


Val Lys Arg Gln Glu Ala Ala Asp Gly His Pro Gly Trp Lys Cys Ser 
65                  70                  75                  80  


Gly Val Ile Val Ala His Cys Gly Leu His Phe Pro Gly Ser Glu Met 
                85                  90                  95      


Gly Phe His His Ala Thr Gln Ala Cys Leu Glu Leu Leu Gly Ser Ser 
            100                 105                 110         


Asp Leu Pro Ala Ser Ala Ser Gln Ser Ala Gly Ile Thr Gly Val Asn 
        115                 120                 125             


His Arg Ala Gln Pro Gly Leu Asn Val Ser Val Asp Lys Phe Thr Ala 
    130                 135                 140                 


Met Ser Ser His Phe Thr Gln Asp Leu Leu Pro Glu Gln Gly Ile Gln 
145                 150                 155                 160 


Asp Ala Phe Pro Lys Arg Ile Leu Arg Gly Tyr Gly Asn Cys Gly Leu 
                165                 170                 175     


Asp Asn Leu Tyr Leu Arg Lys Asp Trp Glu Ser Leu Asp Glu Cys Lys 
            180                 185                 190         


Leu Gln Lys Asp Tyr Asn Gly Leu Asn Gln Cys Ser Ser Thr Thr His 
        195                 200                 205             


Ser Lys Ile Phe Gln Tyr Asn Lys Tyr Val Lys Ile Phe Asp Asn Phe 
    210                 215                 220                 


Ser Asn Leu His Arg Arg Asn Ile Ser Asn Thr Gly Glu Lys Pro Phe 
225                 230                 235                 240 


Lys Cys Gln Glu Cys Gly Lys Ser Phe Gln Met Leu Ser Phe Leu Thr 
                245                 250                 255     


Glu His Gln Lys Ile His Thr Gly Lys Lys Phe Gln Lys Cys Gly Glu 
            260                 265                 270         


Cys Gly Lys Thr Phe Ile Gln Cys Ser His Phe Thr Glu Pro Glu Asn 
        275                 280                 285             


Ile Asp Thr Gly Glu Lys Pro Tyr Lys Cys Gln Glu Cys Asn Asn Val 
    290                 295                 300                 


Ile Lys Thr Cys Ser Val Leu Thr Lys Asn Arg Ile Tyr Ala Gly Gly 
305                 310                 315                 320 


Glu His Tyr Arg Cys Glu Glu Phe Gly Lys Val Phe Asn Gln Cys Ser 
                325                 330                 335     


His Leu Thr Glu His Glu His Gly Thr Glu Glu Lys Pro Cys Lys Tyr 
            340                 345                 350         


Glu Glu Cys Ser Ser Val Phe Ile Ser Cys Ser Ser Leu Ser Asn Gln 
        355                 360                 365             


Gln Met Ile Leu Ala Gly Glu Lys Leu Ser Lys Cys Glu Thr Trp Tyr 
    370                 375                 380                 


Lys Gly Phe Asn His Ser Pro Asn Pro Ser Lys His Gln Arg Asn Glu 
385                 390                 395                 400 


Ile Gly Gly Lys Pro Phe Lys Cys Glu Glu Cys Asp Ser Ile Phe Lys 
                405                 410                 415     


Trp Phe Ser Asp Leu Thr Lys His Lys Arg Ile His Thr Gly Glu Lys 
            420                 425                 430         


Pro Tyr Lys Cys Asp Glu Cys Gly Lys Ala Tyr Thr Gln Ser Ser His 
        435                 440                 445             


Leu Ser Glu His Arg Arg Ile His Thr Gly Glu Lys Pro Tyr Gln Cys 
    450                 455                 460                 


Glu Glu Cys Gly Lys Val Phe Arg Thr Cys Ser Ser Leu Ser Asn His 
465                 470                 475                 480 


Lys Arg Thr His Ser Glu Glu Lys Pro Tyr Thr Cys Glu Glu Cys Gly 
                485                 490                 495     


Asn Ile Phe Lys Gln Leu Ser Asp Leu Thr Lys His Lys Lys Thr His 
            500                 505                 510         


Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly Lys Asn Phe Thr 
        515                 520                 525             


Gln Ser Ser Asn Leu Ile Val His Lys Arg Ile His Thr Gly Glu Lys 
    530                 535                 540                 


Pro Tyr Lys Cys Glu Glu Cys Gly Arg Val Phe Met Trp Phe Ser Asp 
545                 550                 555                 560 


Ile Thr Lys His Lys Lys Thr His Thr Gly Glu Lys Pro Tyr Lys Cys 
                565                 570                 575     


Asp Glu Cys Gly Lys Asn Phe Thr Gln Ser Ser Asn Leu Ile Val His 
            580                 585                 590         


Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Lys Cys Gly 
        595                 600                 605             


Lys Ala Phe Thr Gln Phe Ser His Leu Thr Val His Glu Ser Ile His 
    610                 615                 620                 


Thr 
625 

<210>  2654
<211>  2674
<212>  DNA
<213>  Homo sapiens

<400>  2654
gtcccgacag agctccactt cctgtccccg cggctctgtg tcccctgcta gccgtaggtc     60

gtgtgacccg caggcaccgg gagatccaga agtgaaacgc caggctctct ggaggccagg    120

agatgactct gttgacgttc agggatgtgg ccatagaatt ctccctggag gagtggaaat    180

gcctggacct cgctcagcag aatttgtaca gggatgtgat gttggagaac tacagaaact    240

tgttctccgt tggtctcact gtctgtaagc caggcctgat cacctgcctg gagcaacgaa    300

aagagccctg gaatgtgaag agacaggagg cagcagacgg acatccagca tccgcaaacg    360

tttagcttgt ctttatatct tgacaattgt gaataatgct gcagtgaaca tgagggagca    420

gataattctt caagatgctg cttttattcc cttcagttat tatatacaca gaagtgtgat    480

tgctgcgttg caggctatgt cttctcattt tacccaagac cttctgccag agcagggcat    540

acaagatgca ttcccaaaaa gaatactgag aggatatgga aattgtggcc ttgataattt    600

atatttaagg aaagactggg aaagtttaga tgagtgtaag ttgcaaaaag attataatgg    660

acttaaccaa tgttcatcaa ctacccatag caaaatcttt caatataata aatatgttaa    720

aatctttgat aacttttcaa atttacatag acgtaatata agtaatactg gagagaaacc    780

tttcaaatgt caagaatgtg gcaaatcctt tcaaatgctc tcattcctaa ctgaacatca    840

gaaaattcac actggaaaaa aattccaaaa atgtggagaa tgtggcaaaa cctttatcca    900

gtgctcacac tttactgaac ctgagaacat tgacactgga gagaaacctt acaagtgtca    960

agaatgtaac aacgtcatta aaacttgctc agtccttact aaaaatagaa tttatgccgg   1020

aggggaacat tacagatgtg aagaatttgg caaagtattt aaccagtgct cccaccttac   1080

tgaacatgag catggtactg aggaaaaacc ctgcaaatat gaagagtgca gcagtgtctt   1140

tatctcttgc tcaagccttt ctaatcaaca gatgattctt gctggagaga agctctccaa   1200

atgtgaaaca tggtacaaag gttttaacca cagcccaaat ccttccaaac accagagaaa   1260

tgagattgga gggaaacctt tcaaatgtga ggaatgtgac agcatcttca agtggttctc   1320

agaccttact aaacataaga gaattcacac tggtgagaaa ccatacaaat gtgacgaatg   1380

tgggaaagcc tatacacagt cctcacacct cagtgaacac aggaggattc acaccggaga   1440

gaaaccctac caatgtgaag aatgtgggaa ggtcttcaga acttgctcaa gcctttctaa   1500

ccataagaga actcattctg aagaaaaacc ctacacgtgt gaagaatgtg gcaacatctt   1560

taagcagtta tcagacctca ctaagcataa gaaaacccat actggagaga agccctacaa   1620

atgtgacgaa tgtggaaaaa actttaccca gtcctccaac cttattgtac ataagagaat   1680

tcatactgga gagaaaccct acaagtgtga agaatgtggc agagtcttca tgtggttctc   1740

agacattacc aaacataaga aaacccatac tggagagaaa ccctacaaat gtgacgaatg   1800

tggaaaaaac tttacccagt cctcaaacct tattgtacat aagagaattc atactggaga   1860

gaaaccctac aagtgtgaaa agtgtggcaa agccttcacc cagttctcac acctgactgt   1920

acatgaaagc attcatactt gagaaaaaaa taaacaaata taaaaatagg caaagccgtt   1980

agtatctgct cgcatcccac tttacatcag agttcagact taataaagtt atcataaatg   2040

taattactat tgaaagacct ttcatgaaat ataagtctcc agagcacaca agagtatttc   2100

ttctgaaaaa aatgttacaa ttatactaga tggaagactt gcatcagttg cttaaacttt   2160

cagaaaattt gtagagaaac ccaacaaatc tcataaatgt ggaataacat ttgttcaaaa   2220

atgatagctt agaaaacact agagttcata ctaaaagata ttttgcaaat acactaaatg   2280

ggaaaaataa gcaaggacac gttcagaaat gacactgaat ccctgtgttg agtctacaga   2340

gacatctaga cttaaaatag atcatttata tttaagttta aaaggaggat gagactgagt   2400

ttttgtagag ttataattac attcaaaata tacttttttg cattgaaaaa atgttaaatt   2460

tttgaaaagc gaatattgat gtcattctat tctcaaatca gtagatgctg tgtcttcatt   2520

tctagtgctg atgtgaaaac acatggtcag ttgttgctgc gtcagagata tgagaaattc   2580

ttttctctta ggtgtgcatc actgatatac ttgtccgtga aaggtgaaag acactgaaat   2640

gtaagatgcg tgagtaaaat cttggtagag aggc                               2674


<210>  2655
<211>  510
<212>  PRT
<213>  Homo sapiens

<400>  2655


Met Arg Glu Gln Ile Ile Leu Gln Asp Ala Ala Phe Ile Pro Phe Ser 
1               5                   10                  15      


Tyr Tyr Ile His Arg Ser Val Ile Ala Ala Leu Gln Ala Met Ser Ser 
            20                  25                  30          


His Phe Thr Gln Asp Leu Leu Pro Glu Gln Gly Ile Gln Asp Ala Phe 
        35                  40                  45              


Pro Lys Arg Ile Leu Arg Gly Tyr Gly Asn Cys Gly Leu Asp Asn Leu 
    50                  55                  60                  


Tyr Leu Arg Lys Asp Trp Glu Ser Leu Asp Glu Cys Lys Leu Gln Lys 
65                  70                  75                  80  


Asp Tyr Asn Gly Leu Asn Gln Cys Ser Ser Thr Thr His Ser Lys Ile 
                85                  90                  95      


Phe Gln Tyr Asn Lys Tyr Val Lys Ile Phe Asp Asn Phe Ser Asn Leu 
            100                 105                 110         


His Arg Arg Asn Ile Ser Asn Thr Gly Glu Lys Pro Phe Lys Cys Gln 
        115                 120                 125             


Glu Cys Gly Lys Ser Phe Gln Met Leu Ser Phe Leu Thr Glu His Gln 
    130                 135                 140                 


Lys Ile His Thr Gly Lys Lys Phe Gln Lys Cys Gly Glu Cys Gly Lys 
145                 150                 155                 160 


Thr Phe Ile Gln Cys Ser His Phe Thr Glu Pro Glu Asn Ile Asp Thr 
                165                 170                 175     


Gly Glu Lys Pro Tyr Lys Cys Gln Glu Cys Asn Asn Val Ile Lys Thr 
            180                 185                 190         


Cys Ser Val Leu Thr Lys Asn Arg Ile Tyr Ala Gly Gly Glu His Tyr 
        195                 200                 205             


Arg Cys Glu Glu Phe Gly Lys Val Phe Asn Gln Cys Ser His Leu Thr 
    210                 215                 220                 


Glu His Glu His Gly Thr Glu Glu Lys Pro Cys Lys Tyr Glu Glu Cys 
225                 230                 235                 240 


Ser Ser Val Phe Ile Ser Cys Ser Ser Leu Ser Asn Gln Gln Met Ile 
                245                 250                 255     


Leu Ala Gly Glu Lys Leu Ser Lys Cys Glu Thr Trp Tyr Lys Gly Phe 
            260                 265                 270         


Asn His Ser Pro Asn Pro Ser Lys His Gln Arg Asn Glu Ile Gly Gly 
        275                 280                 285             


Lys Pro Phe Lys Cys Glu Glu Cys Asp Ser Ile Phe Lys Trp Phe Ser 
    290                 295                 300                 


Asp Leu Thr Lys His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys 
305                 310                 315                 320 


Cys Asp Glu Cys Gly Lys Ala Tyr Thr Gln Ser Ser His Leu Ser Glu 
                325                 330                 335     


His Arg Arg Ile His Thr Gly Glu Lys Pro Tyr Gln Cys Glu Glu Cys 
            340                 345                 350         


Gly Lys Val Phe Arg Thr Cys Ser Ser Leu Ser Asn His Lys Arg Thr 
        355                 360                 365             


His Ser Glu Glu Lys Pro Tyr Thr Cys Glu Glu Cys Gly Asn Ile Phe 
    370                 375                 380                 


Lys Gln Leu Ser Asp Leu Thr Lys His Lys Lys Thr His Thr Gly Glu 
385                 390                 395                 400 


Lys Pro Tyr Lys Cys Asp Glu Cys Gly Lys Asn Phe Thr Gln Ser Ser 
                405                 410                 415     


Asn Leu Ile Val His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys 
            420                 425                 430         


Cys Glu Glu Cys Gly Arg Val Phe Met Trp Phe Ser Asp Ile Thr Lys 
        435                 440                 445             


His Lys Lys Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys 
    450                 455                 460                 


Gly Lys Asn Phe Thr Gln Ser Ser Asn Leu Ile Val His Lys Arg Ile 
465                 470                 475                 480 


His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Lys Cys Gly Lys Ala Phe 
                485                 490                 495     


Thr Gln Phe Ser His Leu Thr Val His Glu Ser Ile His Thr 
            500                 505                 510 

<210>  2656
<211>  2294
<212>  DNA
<213>  Homo sapiens

<400>  2656
ttccgggatc tagcggggcc tttgtcccga cagagctcca cttcctgtcc ccgcggctct     60

gtgtcccctg ctagccgtag gtcgtgtgac ccgcaggcac cgggagatcc agaactatgt    120

cttctcattt tacccaagac cttctgccag agcagggcat acaagatgca ttcccaaaaa    180

gaatactgag aggatatgga aattgtggcc ttgataattt atatttaagg aaagactggg    240

aaagtttaga tgagtgtaag ttgcaaaaag attataatgg acttaaccaa tgttcatcaa    300

ctacccatag caaaatcttt caatataata aatatgttaa aatctttgat aacttttcaa    360

atttacatag acgtaatata agtaatactg gagagaaacc tttcaaatgt caagaatgtg    420

gcaaatcctt tcaaatgctc tcattcctaa ctgaacatca gaaaattcac actggaaaaa    480

aattccaaaa atgtggagaa tgtggcaaaa cctttatcca gtgctcacac tttactgaac    540

ctgagaacat tgacactgga gagaaacctt acaagtgtca agaatgtaac aacgtcatta    600

aaacttgctc agtccttact aaaaatagaa tttatgccgg aggggaacat tacagatgtg    660

aagaatttgg caaagtattt aaccagtgct cccaccttac tgaacatgag catggtactg    720

aggaaaaacc ctgcaaatat gaagagtgca gcagtgtctt tatctcttgc tcaagccttt    780

ctaatcaaca gatgattctt gctggagaga agctctccaa atgtgaaaca tggtacaaag    840

gttttaacca cagcccaaat ccttccaaac accagagaaa tgagattgga gggaaacctt    900

tcaaatgtga ggaatgtgac agcatcttca agtggttctc agaccttact aaacataaga    960

gaattcacac tggtgagaaa ccatacaaat gtgacgaatg tgggaaagcc tatacacagt   1020

cctcacacct cagtgaacac aggaggattc acaccggaga gaaaccctac caatgtgaag   1080

aatgtgggaa ggtcttcaga acttgctcaa gcctttctaa ccataagaga actcattctg   1140

aagaaaaacc ctacacgtgt gaagaatgtg gcaacatctt taagcagtta tcagacctca   1200

ctaagcataa gaaaacccat actggagaga agccctacaa atgtgacgaa tgtggaaaaa   1260

actttaccca gtcctccaac cttattgtac ataagagaat tcatactgga gagaaaccct   1320

acaagtgtga agaatgtggc agagtcttca tgtggttctc agacattacc aaacataaga   1380

aaacccatac tggagagaaa ccctacaaat gtgacgaatg tggaaaaaac tttacccagt   1440

cctcaaacct tattgtacat aagagaattc atactggaga gaaaccctac aagtgtgaaa   1500

agtgtggcaa agccttcacc cagttctcac acctgactgt acatgaaagc attcatactt   1560

gagaaaaaaa taaacaaata taaaaatagg caaagccgtt agtatctgct cgcatcccac   1620

tttacatcag agttcagact taataaagtt atcataaatg taattactat tgaaagacct   1680

ttcatgaaat ataagtctcc agagcacaca agagtatttc ttctgaaaaa aatgttacaa   1740

ttatactaga tggaagactt gcatcagttg cttaaacttt cagaaaattt gtagagaaac   1800

ccaacaaatc tcataaatgt ggaataacat ttgttcaaaa atgatagctt agaaaacact   1860

agagttcata ctaaaagata ttttgcaaat acactaaatg ggaaaaataa gcaaggacac   1920

gttcagaaat gacactgaat ccctgtgttg agtctacaga gacatctaga cttaaaatag   1980

atcatttata tttaagttta aaaggaggat gagactgagt ttttgtagag ttataattac   2040

attcaaaata tacttttttg cattgaaaaa atgttaaatt tttgaaaagc gaatattgat   2100

gtcattctat tctcaaatca gtagatgctg tgtcttcatt tctagtgctg atgtgaaaac   2160

acatggtcag ttgttgctgc gtcagagata tgagaaattc ttttctctta ggtgtgcatc   2220

actgatatac ttgtccgtga aaggtgaaag acactgaaat gtaagatgcg tgagtaaaat   2280

cttggtagag aggc                                                     2294


<210>  2657
<211>  481
<212>  PRT
<213>  Homo sapiens

<400>  2657


Met Ser Ser His Phe Thr Gln Asp Leu Leu Pro Glu Gln Gly Ile Gln 
1               5                   10                  15      


Asp Ala Phe Pro Lys Arg Ile Leu Arg Gly Tyr Gly Asn Cys Gly Leu 
            20                  25                  30          


Asp Asn Leu Tyr Leu Arg Lys Asp Trp Glu Ser Leu Asp Glu Cys Lys 
        35                  40                  45              


Leu Gln Lys Asp Tyr Asn Gly Leu Asn Gln Cys Ser Ser Thr Thr His 
    50                  55                  60                  


Ser Lys Ile Phe Gln Tyr Asn Lys Tyr Val Lys Ile Phe Asp Asn Phe 
65                  70                  75                  80  


Ser Asn Leu His Arg Arg Asn Ile Ser Asn Thr Gly Glu Lys Pro Phe 
                85                  90                  95      


Lys Cys Gln Glu Cys Gly Lys Ser Phe Gln Met Leu Ser Phe Leu Thr 
            100                 105                 110         


Glu His Gln Lys Ile His Thr Gly Lys Lys Phe Gln Lys Cys Gly Glu 
        115                 120                 125             


Cys Gly Lys Thr Phe Ile Gln Cys Ser His Phe Thr Glu Pro Glu Asn 
    130                 135                 140                 


Ile Asp Thr Gly Glu Lys Pro Tyr Lys Cys Gln Glu Cys Asn Asn Val 
145                 150                 155                 160 


Ile Lys Thr Cys Ser Val Leu Thr Lys Asn Arg Ile Tyr Ala Gly Gly 
                165                 170                 175     


Glu His Tyr Arg Cys Glu Glu Phe Gly Lys Val Phe Asn Gln Cys Ser 
            180                 185                 190         


His Leu Thr Glu His Glu His Gly Thr Glu Glu Lys Pro Cys Lys Tyr 
        195                 200                 205             


Glu Glu Cys Ser Ser Val Phe Ile Ser Cys Ser Ser Leu Ser Asn Gln 
    210                 215                 220                 


Gln Met Ile Leu Ala Gly Glu Lys Leu Ser Lys Cys Glu Thr Trp Tyr 
225                 230                 235                 240 


Lys Gly Phe Asn His Ser Pro Asn Pro Ser Lys His Gln Arg Asn Glu 
                245                 250                 255     


Ile Gly Gly Lys Pro Phe Lys Cys Glu Glu Cys Asp Ser Ile Phe Lys 
            260                 265                 270         


Trp Phe Ser Asp Leu Thr Lys His Lys Arg Ile His Thr Gly Glu Lys 
        275                 280                 285             


Pro Tyr Lys Cys Asp Glu Cys Gly Lys Ala Tyr Thr Gln Ser Ser His 
    290                 295                 300                 


Leu Ser Glu His Arg Arg Ile His Thr Gly Glu Lys Pro Tyr Gln Cys 
305                 310                 315                 320 


Glu Glu Cys Gly Lys Val Phe Arg Thr Cys Ser Ser Leu Ser Asn His 
                325                 330                 335     


Lys Arg Thr His Ser Glu Glu Lys Pro Tyr Thr Cys Glu Glu Cys Gly 
            340                 345                 350         


Asn Ile Phe Lys Gln Leu Ser Asp Leu Thr Lys His Lys Lys Thr His 
        355                 360                 365             


Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly Lys Asn Phe Thr 
    370                 375                 380                 


Gln Ser Ser Asn Leu Ile Val His Lys Arg Ile His Thr Gly Glu Lys 
385                 390                 395                 400 


Pro Tyr Lys Cys Glu Glu Cys Gly Arg Val Phe Met Trp Phe Ser Asp 
                405                 410                 415     


Ile Thr Lys His Lys Lys Thr His Thr Gly Glu Lys Pro Tyr Lys Cys 
            420                 425                 430         


Asp Glu Cys Gly Lys Asn Phe Thr Gln Ser Ser Asn Leu Ile Val His 
        435                 440                 445             


Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Lys Cys Gly 
    450                 455                 460                 


Lys Ala Phe Thr Gln Phe Ser His Leu Thr Val His Glu Ser Ile His 
465                 470                 475                 480 


Thr 
    

<210>  2658
<211>  2799
<212>  DNA
<213>  Homo sapiens

<400>  2658
atcaggcaca tgtctggaga ggagaggacg gcttccggga tctagcgggg cctttgtccc     60

gacagagctc cacttcctgt ccccgcggct ctgtgtcccc tgctagccgt aggtcgtgtg    120

acccgcaggc accgggagat ccagaagtga aacgccaggc tctctggagg ccaggagatg    180

actctgttga cgttcaggga tgtggccata gaattctccc tggaggagtg gaaatgcctg    240

gacctcgctc agcagaattt gtacagggat gtgatgttgg agaactacag aaacttgttc    300

tccgttggtc tcactgtctg taagccaggc ctgatcacct gcctggagca acgaaaagag    360

ccctggaatg tgaagagaca ggaggcagca gacggacatc cagagatggg atttcaccat    420

gctactcagg cttgtcttga actcctgggc tcaagcgatc tgcctgcctc agcctcccaa    480

agtgctggga ttacaggtgt gaaccaccgt gcccagccag gcctcaatgt ttctgtggac    540

aaattcactg cactgtgctc acctggggtg ctgcaaactg tgaaatggtt tttagagttc    600

agatgcatct tctcactagc tatgtcttct cattttaccc aagaccttct gccagagcag    660

ggcatacaag atgcattccc aaaaagaata ctgagaggat atggaaattg tggccttgat    720

aatttatatt taaggaaaga ctgggaaagt ttagatgagt gtaagttgca aaaagattat    780

aatggactta accaatgttc atcaactacc catagcaaaa tctttcaata taataaatat    840

gttaaaatct ttgataactt ttcaaattta catagacgta atataagtaa tactggagag    900

aaacctttca aatgtcaaga atgtggcaaa tcctttcaaa tgctctcatt cctaactgaa    960

catcagaaaa ttcacactgg aaaaaaattc caaaaatgtg gagaatgtgg caaaaccttt   1020

atccagtgct cacactttac tgaacctgag aacattgaca ctggagagaa accttacaag   1080

tgtcaagaat gtaacaacgt cattaaaact tgctcagtcc ttactaaaaa tagaatttat   1140

gccggagggg aacattacag atgtgaagaa tttggcaaag tatttaacca gtgctcccac   1200

cttactgaac atgagcatgg tactgaggaa aaaccctgca aatatgaaga gtgcagcagt   1260

gtctttatct cttgctcaag cctttctaat caacagatga ttcttgctgg agagaagctc   1320

tccaaatgtg aaacatggta caaaggtttt aaccacagcc caaatccttc caaacaccag   1380

agaaatgaga ttggagggaa acctttcaaa tgtgaggaat gtgacagcat cttcaagtgg   1440

ttctcagacc ttactaaaca taagagaatt cacactggtg agaaaccata caaatgtgac   1500

gaatgtggga aagcctatac acagtcctca cacctcagtg aacacaggag gattcacacc   1560

ggagagaaac cctaccaatg tgaagaatgt gggaaggtct tcagaacttg ctcaagcctt   1620

tctaaccata agagaactca ttctgaagaa aaaccctaca cgtgtgaaga atgtggcaac   1680

atctttaagc agttatcaga cctcactaag cataagaaaa cccatactgg agagaagccc   1740

tacaaatgtg acgaatgtgg aaaaaacttt acccagtcct ccaaccttat tgtacataag   1800

agaattcata ctggagagaa accctacaag tgtgaagaat gtggcagagt cttcatgtgg   1860

ttctcagaca ttaccaaaca taagaaaacc catactggag agaaacccta caaatgtgac   1920

gaatgtggaa aaaactttac ccagtcctca aaccttattg tacataagag aattcatact   1980

ggagagaaac cctacaagtg tgaaaagtgt ggcaaagcct tcacccagtt ctcacacctg   2040

actgtacatg aaagcattca tacttgagaa aaaaataaac aaatataaaa ataggcaaag   2100

ccgttagtat ctgctcgcat cccactttac atcagagttc agacttaata aagttatcat   2160

aaatgtaatt actattgaaa gacctttcat gaaatataag tctccagagc acacaagagt   2220

atttcttctg aaaaaaatgt tacaattata ctagatggaa gacttgcatc agttgcttaa   2280

actttcagaa aatttgtaga gaaacccaac aaatctcata aatgtggaat aacatttgtt   2340

caaaaatgat agcttagaaa acactagagt tcatactaaa agatattttg caaatacact   2400

aaatgggaaa aataagcaag gacacgttca gaaatgacac tgaatccctg tgttgagtct   2460

acagagacat ctagacttaa aatagatcat ttatatttaa gtttaaaagg aggatgagac   2520

tgagtttttg tagagttata attacattca aaatatactt ttttgcattg aaaaaatgtt   2580

aaatttttga aaagcgaata ttgatgtcat tctattctca aatcagtaga tgctgtgtct   2640

tcatttctag tgctgatgtg aaaacacatg gtcagttgtt gctgcgtcag agatatgaga   2700

aattcttttc tcttaggtgt gcatcactga tatacttgtc cgtgaaaggt gaaagacact   2760

gaaatgtaag atgcgtgagt aaaatcttgg tagagaggc                          2799


<210>  2659
<211>  629
<212>  PRT
<213>  Homo sapiens

<400>  2659


Met Thr Leu Leu Thr Phe Arg Asp Val Ala Ile Glu Phe Ser Leu Glu 
1               5                   10                  15      


Glu Trp Lys Cys Leu Asp Leu Ala Gln Gln Asn Leu Tyr Arg Asp Val 
            20                  25                  30          


Met Leu Glu Asn Tyr Arg Asn Leu Phe Ser Val Gly Leu Thr Val Cys 
        35                  40                  45              


Lys Pro Gly Leu Ile Thr Cys Leu Glu Gln Arg Lys Glu Pro Trp Asn 
    50                  55                  60                  


Val Lys Arg Gln Glu Ala Ala Asp Gly His Pro Glu Met Gly Phe His 
65                  70                  75                  80  


His Ala Thr Gln Ala Cys Leu Glu Leu Leu Gly Ser Ser Asp Leu Pro 
                85                  90                  95      


Ala Ser Ala Ser Gln Ser Ala Gly Ile Thr Gly Val Asn His Arg Ala 
            100                 105                 110         


Gln Pro Gly Leu Asn Val Ser Val Asp Lys Phe Thr Ala Leu Cys Ser 
        115                 120                 125             


Pro Gly Val Leu Gln Thr Val Lys Trp Phe Leu Glu Phe Arg Cys Ile 
    130                 135                 140                 


Phe Ser Leu Ala Met Ser Ser His Phe Thr Gln Asp Leu Leu Pro Glu 
145                 150                 155                 160 


Gln Gly Ile Gln Asp Ala Phe Pro Lys Arg Ile Leu Arg Gly Tyr Gly 
                165                 170                 175     


Asn Cys Gly Leu Asp Asn Leu Tyr Leu Arg Lys Asp Trp Glu Ser Leu 
            180                 185                 190         


Asp Glu Cys Lys Leu Gln Lys Asp Tyr Asn Gly Leu Asn Gln Cys Ser 
        195                 200                 205             


Ser Thr Thr His Ser Lys Ile Phe Gln Tyr Asn Lys Tyr Val Lys Ile 
    210                 215                 220                 


Phe Asp Asn Phe Ser Asn Leu His Arg Arg Asn Ile Ser Asn Thr Gly 
225                 230                 235                 240 


Glu Lys Pro Phe Lys Cys Gln Glu Cys Gly Lys Ser Phe Gln Met Leu 
                245                 250                 255     


Ser Phe Leu Thr Glu His Gln Lys Ile His Thr Gly Lys Lys Phe Gln 
            260                 265                 270         


Lys Cys Gly Glu Cys Gly Lys Thr Phe Ile Gln Cys Ser His Phe Thr 
        275                 280                 285             


Glu Pro Glu Asn Ile Asp Thr Gly Glu Lys Pro Tyr Lys Cys Gln Glu 
    290                 295                 300                 


Cys Asn Asn Val Ile Lys Thr Cys Ser Val Leu Thr Lys Asn Arg Ile 
305                 310                 315                 320 


Tyr Ala Gly Gly Glu His Tyr Arg Cys Glu Glu Phe Gly Lys Val Phe 
                325                 330                 335     


Asn Gln Cys Ser His Leu Thr Glu His Glu His Gly Thr Glu Glu Lys 
            340                 345                 350         


Pro Cys Lys Tyr Glu Glu Cys Ser Ser Val Phe Ile Ser Cys Ser Ser 
        355                 360                 365             


Leu Ser Asn Gln Gln Met Ile Leu Ala Gly Glu Lys Leu Ser Lys Cys 
    370                 375                 380                 


Glu Thr Trp Tyr Lys Gly Phe Asn His Ser Pro Asn Pro Ser Lys His 
385                 390                 395                 400 


Gln Arg Asn Glu Ile Gly Gly Lys Pro Phe Lys Cys Glu Glu Cys Asp 
                405                 410                 415     


Ser Ile Phe Lys Trp Phe Ser Asp Leu Thr Lys His Lys Arg Ile His 
            420                 425                 430         


Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly Lys Ala Tyr Thr 
        435                 440                 445             


Gln Ser Ser His Leu Ser Glu His Arg Arg Ile His Thr Gly Glu Lys 
    450                 455                 460                 


Pro Tyr Gln Cys Glu Glu Cys Gly Lys Val Phe Arg Thr Cys Ser Ser 
465                 470                 475                 480 


Leu Ser Asn His Lys Arg Thr His Ser Glu Glu Lys Pro Tyr Thr Cys 
                485                 490                 495     


Glu Glu Cys Gly Asn Ile Phe Lys Gln Leu Ser Asp Leu Thr Lys His 
            500                 505                 510         


Lys Lys Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly 
        515                 520                 525             


Lys Asn Phe Thr Gln Ser Ser Asn Leu Ile Val His Lys Arg Ile His 
    530                 535                 540                 


Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Arg Val Phe Met 
545                 550                 555                 560 


Trp Phe Ser Asp Ile Thr Lys His Lys Lys Thr His Thr Gly Glu Lys 
                565                 570                 575     


Pro Tyr Lys Cys Asp Glu Cys Gly Lys Asn Phe Thr Gln Ser Ser Asn 
            580                 585                 590         


Leu Ile Val His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys 
        595                 600                 605             


Glu Lys Cys Gly Lys Ala Phe Thr Gln Phe Ser His Leu Thr Val His 
    610                 615                 620                 


Glu Ser Ile His Thr 
625                 

<210>  2660
<211>  2730
<212>  DNA
<213>  Homo sapiens

<400>  2660
atcaggcaca tgtctggaga ggagaggacg gcttccggga tctagcgggg cctttgtccc     60

gacagagctc cacttcctgt ccccgcggct ctgtgtcccc tgctagccgt aggtcgtgtg    120

acccgcaggc accgggagat ccagaagtga aacgccaggc tctctggagg ccaggagatg    180

actctgttga cgttcaggga tgtggccata gaattctccc tggaggagtg gaaatgcctg    240

gacctcgctc agcagaattt gtacagggat gtgatgttgg agaactacag aaacttgttc    300

tccgttggtc tcactgtctg taagccaggc ctgatcacct gcctggagca acgaaaagag    360

ccctggaatg tgaagagaca ggaggcagca gacggacatc cagagatggg atttcaccat    420

gctactcagg cttgtcttga actcctgggc tcaagcgatc tgcctgcctc agcctcccaa    480

agtgctggga ttacaggtgt gaaccaccgt gcccagccag gcctcaatgt ttctgtggac    540

aaattcactg ctatgtcttc tcattttacc caagaccttc tgccagagca gggcatacaa    600

gatgcattcc caaaaagaat actgagagga tatggaaatt gtggccttga taatttatat    660

ttaaggaaag actgggaaag tttagatgag tgtaagttgc aaaaagatta taatggactt    720

aaccaatgtt catcaactac ccatagcaaa atctttcaat ataataaata tgttaaaatc    780

tttgataact tttcaaattt acatagacgt aatataagta atactggaga gaaacctttc    840

aaatgtcaag aatgtggcaa atcctttcaa atgctctcat tcctaactga acatcagaaa    900

attcacactg gaaaaaaatt ccaaaaatgt ggagaatgtg gcaaaacctt tatccagtgc    960

tcacacttta ctgaacctga gaacattgac actggagaga aaccttacaa gtgtcaagaa   1020

tgtaacaacg tcattaaaac ttgctcagtc cttactaaaa atagaattta tgccggaggg   1080

gaacattaca gatgtgaaga atttggcaaa gtatttaacc agtgctccca ccttactgaa   1140

catgagcatg gtactgagga aaaaccctgc aaatatgaag agtgcagcag tgtctttatc   1200

tcttgctcaa gcctttctaa tcaacagatg attcttgctg gagagaagct ctccaaatgt   1260

gaaacatggt acaaaggttt taaccacagc ccaaatcctt ccaaacacca gagaaatgag   1320

attggaggga aacctttcaa atgtgaggaa tgtgacagca tcttcaagtg gttctcagac   1380

cttactaaac ataagagaat tcacactggt gagaaaccat acaaatgtga cgaatgtggg   1440

aaagcctata cacagtcctc acacctcagt gaacacagga ggattcacac cggagagaaa   1500

ccctaccaat gtgaagaatg tgggaaggtc ttcagaactt gctcaagcct ttctaaccat   1560

aagagaactc attctgaaga aaaaccctac acgtgtgaag aatgtggcaa catctttaag   1620

cagttatcag acctcactaa gcataagaaa acccatactg gagagaagcc ctacaaatgt   1680

gacgaatgtg gaaaaaactt tacccagtcc tccaacctta ttgtacataa gagaattcat   1740

actggagaga aaccctacaa gtgtgaagaa tgtggcagag tcttcatgtg gttctcagac   1800

attaccaaac ataagaaaac ccatactgga gagaaaccct acaaatgtga cgaatgtgga   1860

aaaaacttta cccagtcctc aaaccttatt gtacataaga gaattcatac tggagagaaa   1920

ccctacaagt gtgaaaagtg tggcaaagcc ttcacccagt tctcacacct gactgtacat   1980

gaaagcattc atacttgaga aaaaaataaa caaatataaa aataggcaaa gccgttagta   2040

tctgctcgca tcccacttta catcagagtt cagacttaat aaagttatca taaatgtaat   2100

tactattgaa agacctttca tgaaatataa gtctccagag cacacaagag tatttcttct   2160

gaaaaaaatg ttacaattat actagatgga agacttgcat cagttgctta aactttcaga   2220

aaatttgtag agaaacccaa caaatctcat aaatgtggaa taacatttgt tcaaaaatga   2280

tagcttagaa aacactagag ttcatactaa aagatatttt gcaaatacac taaatgggaa   2340

aaataagcaa ggacacgttc agaaatgaca ctgaatccct gtgttgagtc tacagagaca   2400

tctagactta aaatagatca tttatattta agtttaaaag gaggatgaga ctgagttttt   2460

gtagagttat aattacattc aaaatatact tttttgcatt gaaaaaatgt taaatttttg   2520

aaaagcgaat attgatgtca ttctattctc aaatcagtag atgctgtgtc ttcatttcta   2580

gtgctgatgt gaaaacacat ggtcagttgt tgctgcgtca gagatatgag aaattctttt   2640

ctcttaggtg tgcatcactg atatacttgt ccgtgaaagg tgaaagacac tgaaatgtaa   2700

gatgcgtgag taaaatcttg gtagagaggc                                    2730


<210>  2661
<211>  606
<212>  PRT
<213>  Homo sapiens

<400>  2661


Met Thr Leu Leu Thr Phe Arg Asp Val Ala Ile Glu Phe Ser Leu Glu 
1               5                   10                  15      


Glu Trp Lys Cys Leu Asp Leu Ala Gln Gln Asn Leu Tyr Arg Asp Val 
            20                  25                  30          


Met Leu Glu Asn Tyr Arg Asn Leu Phe Ser Val Gly Leu Thr Val Cys 
        35                  40                  45              


Lys Pro Gly Leu Ile Thr Cys Leu Glu Gln Arg Lys Glu Pro Trp Asn 
    50                  55                  60                  


Val Lys Arg Gln Glu Ala Ala Asp Gly His Pro Glu Met Gly Phe His 
65                  70                  75                  80  


His Ala Thr Gln Ala Cys Leu Glu Leu Leu Gly Ser Ser Asp Leu Pro 
                85                  90                  95      


Ala Ser Ala Ser Gln Ser Ala Gly Ile Thr Gly Val Asn His Arg Ala 
            100                 105                 110         


Gln Pro Gly Leu Asn Val Ser Val Asp Lys Phe Thr Ala Met Ser Ser 
        115                 120                 125             


His Phe Thr Gln Asp Leu Leu Pro Glu Gln Gly Ile Gln Asp Ala Phe 
    130                 135                 140                 


Pro Lys Arg Ile Leu Arg Gly Tyr Gly Asn Cys Gly Leu Asp Asn Leu 
145                 150                 155                 160 


Tyr Leu Arg Lys Asp Trp Glu Ser Leu Asp Glu Cys Lys Leu Gln Lys 
                165                 170                 175     


Asp Tyr Asn Gly Leu Asn Gln Cys Ser Ser Thr Thr His Ser Lys Ile 
            180                 185                 190         


Phe Gln Tyr Asn Lys Tyr Val Lys Ile Phe Asp Asn Phe Ser Asn Leu 
        195                 200                 205             


His Arg Arg Asn Ile Ser Asn Thr Gly Glu Lys Pro Phe Lys Cys Gln 
    210                 215                 220                 


Glu Cys Gly Lys Ser Phe Gln Met Leu Ser Phe Leu Thr Glu His Gln 
225                 230                 235                 240 


Lys Ile His Thr Gly Lys Lys Phe Gln Lys Cys Gly Glu Cys Gly Lys 
                245                 250                 255     


Thr Phe Ile Gln Cys Ser His Phe Thr Glu Pro Glu Asn Ile Asp Thr 
            260                 265                 270         


Gly Glu Lys Pro Tyr Lys Cys Gln Glu Cys Asn Asn Val Ile Lys Thr 
        275                 280                 285             


Cys Ser Val Leu Thr Lys Asn Arg Ile Tyr Ala Gly Gly Glu His Tyr 
    290                 295                 300                 


Arg Cys Glu Glu Phe Gly Lys Val Phe Asn Gln Cys Ser His Leu Thr 
305                 310                 315                 320 


Glu His Glu His Gly Thr Glu Glu Lys Pro Cys Lys Tyr Glu Glu Cys 
                325                 330                 335     


Ser Ser Val Phe Ile Ser Cys Ser Ser Leu Ser Asn Gln Gln Met Ile 
            340                 345                 350         


Leu Ala Gly Glu Lys Leu Ser Lys Cys Glu Thr Trp Tyr Lys Gly Phe 
        355                 360                 365             


Asn His Ser Pro Asn Pro Ser Lys His Gln Arg Asn Glu Ile Gly Gly 
    370                 375                 380                 


Lys Pro Phe Lys Cys Glu Glu Cys Asp Ser Ile Phe Lys Trp Phe Ser 
385                 390                 395                 400 


Asp Leu Thr Lys His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys 
                405                 410                 415     


Cys Asp Glu Cys Gly Lys Ala Tyr Thr Gln Ser Ser His Leu Ser Glu 
            420                 425                 430         


His Arg Arg Ile His Thr Gly Glu Lys Pro Tyr Gln Cys Glu Glu Cys 
        435                 440                 445             


Gly Lys Val Phe Arg Thr Cys Ser Ser Leu Ser Asn His Lys Arg Thr 
    450                 455                 460                 


His Ser Glu Glu Lys Pro Tyr Thr Cys Glu Glu Cys Gly Asn Ile Phe 
465                 470                 475                 480 


Lys Gln Leu Ser Asp Leu Thr Lys His Lys Lys Thr His Thr Gly Glu 
                485                 490                 495     


Lys Pro Tyr Lys Cys Asp Glu Cys Gly Lys Asn Phe Thr Gln Ser Ser 
            500                 505                 510         


Asn Leu Ile Val His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys 
        515                 520                 525             


Cys Glu Glu Cys Gly Arg Val Phe Met Trp Phe Ser Asp Ile Thr Lys 
    530                 535                 540                 


His Lys Lys Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys 
545                 550                 555                 560 


Gly Lys Asn Phe Thr Gln Ser Ser Asn Leu Ile Val His Lys Arg Ile 
                565                 570                 575     


His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Lys Cys Gly Lys Ala Phe 
            580                 585                 590         


Thr Gln Phe Ser His Leu Thr Val His Glu Ser Ile His Thr 
        595                 600                 605     

<210>  2662
<211>  2757
<212>  DNA
<213>  Homo sapiens

<400>  2662
aatcaggcac atgtctggag aggagaggac ggcttccggg atctagcggg gcctttgtcc     60

cgacagagct ccacttcctg tccccgcggc tctgtgtccc ctgctagccg taggtcgtgt    120

gacccgcagg caccgggaga tccagaagtg aaacgccagg ctctctggag gccaggagat    180

ggtgtgattt gtccagagaa tctttcctaa gaggaaatcc cagagaagca ggagaaagag    240

aaagaaatgg ctggtgctca gactctgttg acgttcaggg atgtggccat agaattctcc    300

ctggaggagt ggaaatgcct ggacctcgct cagcagaatt tgtacaggga tgtgatgttg    360

gagaactaca gaaacttgtt ctccgttggt ctcactgtct gtaagccagg cctgatcacc    420

tgcctggagc aacgaaaaga gccctggaat gtgaagagac aggaggcagc agacggacat    480

ccagagatgg gatttcacca tgctactcag gcttgtcttg aactcctggg ctcaagcgat    540

ctgcctgcct cagcctccca aagtgctggg attacagcta tgtcttctca ttttacccaa    600

gaccttctgc cagagcaggg catacaagat gcattcccaa aaagaatact gagaggatat    660

ggaaattgtg gccttgataa tttatattta aggaaagact gggaaagttt agatgagtgt    720

aagttgcaaa aagattataa tggacttaac caatgttcat caactaccca tagcaaaatc    780

tttcaatata ataaatatgt taaaatcttt gataactttt caaatttaca tagacgtaat    840

ataagtaata ctggagagaa acctttcaaa tgtcaagaat gtggcaaatc ctttcaaatg    900

ctctcattcc taactgaaca tcagaaaatt cacactggaa aaaaattcca aaaatgtgga    960

gaatgtggca aaacctttat ccagtgctca cactttactg aacctgagaa cattgacact   1020

ggagagaaac cttacaagtg tcaagaatgt aacaacgtca ttaaaacttg ctcagtcctt   1080

actaaaaata gaatttatgc cggaggggaa cattacagat gtgaagaatt tggcaaagta   1140

tttaaccagt gctcccacct tactgaacat gagcatggta ctgaggaaaa accctgcaaa   1200

tatgaagagt gcagcagtgt ctttatctct tgctcaagcc tttctaatca acagatgatt   1260

cttgctggag agaagctctc caaatgtgaa acatggtaca aaggttttaa ccacagccca   1320

aatccttcca aacaccagag aaatgagatt ggagggaaac ctttcaaatg tgaggaatgt   1380

gacagcatct tcaagtggtt ctcagacctt actaaacata agagaattca cactggtgag   1440

aaaccataca aatgtgacga atgtgggaaa gcctatacac agtcctcaca cctcagtgaa   1500

cacaggagga ttcacaccgg agagaaaccc taccaatgtg aagaatgtgg gaaggtcttc   1560

agaacttgct caagcctttc taaccataag agaactcatt ctgaagaaaa accctacacg   1620

tgtgaagaat gtggcaacat ctttaagcag ttatcagacc tcactaagca taagaaaacc   1680

catactggag agaagcccta caaatgtgac gaatgtggaa aaaactttac ccagtcctcc   1740

aaccttattg tacataagag aattcatact ggagagaaac cctacaagtg tgaagaatgt   1800

ggcagagtct tcatgtggtt ctcagacatt accaaacata agaaaaccca tactggagag   1860

aaaccctaca aatgtgacga atgtggaaaa aactttaccc agtcctcaaa ccttattgta   1920

cataagagaa ttcatactgg agagaaaccc tacaagtgtg aaaagtgtgg caaagccttc   1980

acccagttct cacacctgac tgtacatgaa agcattcata cttgagaaaa aaataaacaa   2040

atataaaaat aggcaaagcc gttagtatct gctcgcatcc cactttacat cagagttcag   2100

acttaataaa gttatcataa atgtaattac tattgaaaga cctttcatga aatataagtc   2160

tccagagcac acaagagtat ttcttctgaa aaaaatgtta caattatact agatggaaga   2220

cttgcatcag ttgcttaaac tttcagaaaa tttgtagaga aacccaacaa atctcataaa   2280

tgtggaataa catttgttca aaaatgatag cttagaaaac actagagttc atactaaaag   2340

atattttgca aatacactaa atgggaaaaa taagcaagga cacgttcaga aatgacactg   2400

aatccctgtg ttgagtctac agagacatct agacttaaaa tagatcattt atatttaagt   2460

ttaaaaggag gatgagactg agtttttgta gagttataat tacattcaaa atatactttt   2520

ttgcattgaa aaaatgttaa atttttgaaa agcgaatatt gatgtcattc tattctcaaa   2580

tcagtagatg ctgtgtcttc atttctagtg ctgatgtgaa aacacatggt cagttgttgc   2640

tgcgtcagag atatgagaaa ttcttttctc ttaggtgtgc atcactgata tacttgtccg   2700

tgaaaggtga aagacactga aatgtaagat gcgtgagtaa aatcttggta gagaggc      2757


<210>  2663
<211>  592
<212>  PRT
<213>  Homo sapiens

<400>  2663


Met Ala Gly Ala Gln Thr Leu Leu Thr Phe Arg Asp Val Ala Ile Glu 
1               5                   10                  15      


Phe Ser Leu Glu Glu Trp Lys Cys Leu Asp Leu Ala Gln Gln Asn Leu 
            20                  25                  30          


Tyr Arg Asp Val Met Leu Glu Asn Tyr Arg Asn Leu Phe Ser Val Gly 
        35                  40                  45              


Leu Thr Val Cys Lys Pro Gly Leu Ile Thr Cys Leu Glu Gln Arg Lys 
    50                  55                  60                  


Glu Pro Trp Asn Val Lys Arg Gln Glu Ala Ala Asp Gly His Pro Glu 
65                  70                  75                  80  


Met Gly Phe His His Ala Thr Gln Ala Cys Leu Glu Leu Leu Gly Ser 
                85                  90                  95      


Ser Asp Leu Pro Ala Ser Ala Ser Gln Ser Ala Gly Ile Thr Ala Met 
            100                 105                 110         


Ser Ser His Phe Thr Gln Asp Leu Leu Pro Glu Gln Gly Ile Gln Asp 
        115                 120                 125             


Ala Phe Pro Lys Arg Ile Leu Arg Gly Tyr Gly Asn Cys Gly Leu Asp 
    130                 135                 140                 


Asn Leu Tyr Leu Arg Lys Asp Trp Glu Ser Leu Asp Glu Cys Lys Leu 
145                 150                 155                 160 


Gln Lys Asp Tyr Asn Gly Leu Asn Gln Cys Ser Ser Thr Thr His Ser 
                165                 170                 175     


Lys Ile Phe Gln Tyr Asn Lys Tyr Val Lys Ile Phe Asp Asn Phe Ser 
            180                 185                 190         


Asn Leu His Arg Arg Asn Ile Ser Asn Thr Gly Glu Lys Pro Phe Lys 
        195                 200                 205             


Cys Gln Glu Cys Gly Lys Ser Phe Gln Met Leu Ser Phe Leu Thr Glu 
    210                 215                 220                 


His Gln Lys Ile His Thr Gly Lys Lys Phe Gln Lys Cys Gly Glu Cys 
225                 230                 235                 240 


Gly Lys Thr Phe Ile Gln Cys Ser His Phe Thr Glu Pro Glu Asn Ile 
                245                 250                 255     


Asp Thr Gly Glu Lys Pro Tyr Lys Cys Gln Glu Cys Asn Asn Val Ile 
            260                 265                 270         


Lys Thr Cys Ser Val Leu Thr Lys Asn Arg Ile Tyr Ala Gly Gly Glu 
        275                 280                 285             


His Tyr Arg Cys Glu Glu Phe Gly Lys Val Phe Asn Gln Cys Ser His 
    290                 295                 300                 


Leu Thr Glu His Glu His Gly Thr Glu Glu Lys Pro Cys Lys Tyr Glu 
305                 310                 315                 320 


Glu Cys Ser Ser Val Phe Ile Ser Cys Ser Ser Leu Ser Asn Gln Gln 
                325                 330                 335     


Met Ile Leu Ala Gly Glu Lys Leu Ser Lys Cys Glu Thr Trp Tyr Lys 
            340                 345                 350         


Gly Phe Asn His Ser Pro Asn Pro Ser Lys His Gln Arg Asn Glu Ile 
        355                 360                 365             


Gly Gly Lys Pro Phe Lys Cys Glu Glu Cys Asp Ser Ile Phe Lys Trp 
    370                 375                 380                 


Phe Ser Asp Leu Thr Lys His Lys Arg Ile His Thr Gly Glu Lys Pro 
385                 390                 395                 400 


Tyr Lys Cys Asp Glu Cys Gly Lys Ala Tyr Thr Gln Ser Ser His Leu 
                405                 410                 415     


Ser Glu His Arg Arg Ile His Thr Gly Glu Lys Pro Tyr Gln Cys Glu 
            420                 425                 430         


Glu Cys Gly Lys Val Phe Arg Thr Cys Ser Ser Leu Ser Asn His Lys 
        435                 440                 445             


Arg Thr His Ser Glu Glu Lys Pro Tyr Thr Cys Glu Glu Cys Gly Asn 
    450                 455                 460                 


Ile Phe Lys Gln Leu Ser Asp Leu Thr Lys His Lys Lys Thr His Thr 
465                 470                 475                 480 


Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly Lys Asn Phe Thr Gln 
                485                 490                 495     


Ser Ser Asn Leu Ile Val His Lys Arg Ile His Thr Gly Glu Lys Pro 
            500                 505                 510         


Tyr Lys Cys Glu Glu Cys Gly Arg Val Phe Met Trp Phe Ser Asp Ile 
        515                 520                 525             


Thr Lys His Lys Lys Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Asp 
    530                 535                 540                 


Glu Cys Gly Lys Asn Phe Thr Gln Ser Ser Asn Leu Ile Val His Lys 
545                 550                 555                 560 


Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Lys Cys Gly Lys 
                565                 570                 575     


Ala Phe Thr Gln Phe Ser His Leu Thr Val His Glu Ser Ile His Thr 
            580                 585                 590         

<210>  2664
<211>  2881
<212>  DNA
<213>  Homo sapiens

<400>  2664
aatcaggcac atgtctggag aggagaggac ggcttccggg atctagcggg gcctttgtcc     60

cgacagagct ccacttcctg tccccgcggc tctgtgtccc ctgctagccg taggtcgtgt    120

gacccgcagg caccgggaga tccagaagtg aaacgccagg ctctctggag gccaggagat    180

ggtgtgattt gtccagagaa tctttcctaa gaggaaatcc cagagaagca ggagaaagag    240

aaagaaatgg ctggtgctca gactctgttg acgttcaggg atgtggccat agaattctcc    300

ctggaggagt ggaaatgcct ggacctcgct cagcagaatt tgtacaggga tgtgatgttg    360

gagaactaca gaaacttgtt ctccgttggt ctcactgtct gtaagccagg cctgatcacc    420

tgcctggagc aacgaaaaga gccctggaat gtgaagagac aggaggcagc agacggacat    480

ccaggtattt tctttgtggt taccatggaa attatataaa acatcttaaa gttacaacaa    540

ggtattttac actgagatgg gatttcacca tgctactcag gcttgtcttg aactcctggg    600

ctcaagcgat ctgcctgcct cagcctccca aagtgctggg attacaggtg tgaaccaccg    660

tgcccagcca ggcctcaatg tttctgtgga caaattcact gctatgtctt ctcattttac    720

ccaagacctt ctgccagagc agggcataca agatgcattc ccaaaaagaa tactgagagg    780

atatggaaat tgtggccttg ataatttata tttaaggaaa gactgggaaa gtttagatga    840

gtgtaagttg caaaaagatt ataatggact taaccaatgt tcatcaacta cccatagcaa    900

aatctttcaa tataataaat atgttaaaat ctttgataac ttttcaaatt tacatagacg    960

taatataagt aatactggag agaaaccttt caaatgtcaa gaatgtggca aatcctttca   1020

aatgctctca ttcctaactg aacatcagaa aattcacact ggaaaaaaat tccaaaaatg   1080

tggagaatgt ggcaaaacct ttatccagtg ctcacacttt actgaacctg agaacattga   1140

cactggagag aaaccttaca agtgtcaaga atgtaacaac gtcattaaaa cttgctcagt   1200

ccttactaaa aatagaattt atgccggagg ggaacattac agatgtgaag aatttggcaa   1260

agtatttaac cagtgctccc accttactga acatgagcat ggtactgagg aaaaaccctg   1320

caaatatgaa gagtgcagca gtgtctttat ctcttgctca agcctttcta atcaacagat   1380

gattcttgct ggagagaagc tctccaaatg tgaaacatgg tacaaaggtt ttaaccacag   1440

cccaaatcct tccaaacacc agagaaatga gattggaggg aaacctttca aatgtgagga   1500

atgtgacagc atcttcaagt ggttctcaga ccttactaaa cataagagaa ttcacactgg   1560

tgagaaacca tacaaatgtg acgaatgtgg gaaagcctat acacagtcct cacacctcag   1620

tgaacacagg aggattcaca ccggagagaa accctaccaa tgtgaagaat gtgggaaggt   1680

cttcagaact tgctcaagcc tttctaacca taagagaact cattctgaag aaaaacccta   1740

cacgtgtgaa gaatgtggca acatctttaa gcagttatca gacctcacta agcataagaa   1800

aacccatact ggagagaagc cctacaaatg tgacgaatgt ggaaaaaact ttacccagtc   1860

ctccaacctt attgtacata agagaattca tactggagag aaaccctaca agtgtgaaga   1920

atgtggcaga gtcttcatgt ggttctcaga cattaccaaa cataagaaaa cccatactgg   1980

agagaaaccc tacaaatgtg acgaatgtgg aaaaaacttt acccagtcct caaaccttat   2040

tgtacataag agaattcata ctggagagaa accctacaag tgtgaaaagt gtggcaaagc   2100

cttcacccag ttctcacacc tgactgtaca tgaaagcatt catacttgag aaaaaaataa   2160

acaaatataa aaataggcaa agccgttagt atctgctcgc atcccacttt acatcagagt   2220

tcagacttaa taaagttatc ataaatgtaa ttactattga aagacctttc atgaaatata   2280

agtctccaga gcacacaaga gtatttcttc tgaaaaaaat gttacaatta tactagatgg   2340

aagacttgca tcagttgctt aaactttcag aaaatttgta gagaaaccca acaaatctca   2400

taaatgtgga ataacatttg ttcaaaaatg atagcttaga aaacactaga gttcatacta   2460

aaagatattt tgcaaataca ctaaatggga aaaataagca aggacacgtt cagaaatgac   2520

actgaatccc tgtgttgagt ctacagagac atctagactt aaaatagatc atttatattt   2580

aagtttaaaa ggaggatgag actgagtttt tgtagagtta taattacatt caaaatatac   2640

ttttttgcat tgaaaaaatg ttaaattttt gaaaagcgaa tattgatgtc attctattct   2700

caaatcagta gatgctgtgt cttcatttct agtgctgatg tgaaaacaca tggtcagttg   2760

ttgctgcgtc agagatatga gaaattcttt tctcttaggt gtgcatcact gatatacttg   2820

tccgtgaaag gtgaaagaca ctgaaatgta agatgcgtga gtaaaatctt ggtagagagg   2880

c                                                                   2881


<210>  2665
<211>  530
<212>  PRT
<213>  Homo sapiens

<400>  2665


Met Gly Phe His His Ala Thr Gln Ala Cys Leu Glu Leu Leu Gly Ser 
1               5                   10                  15      


Ser Asp Leu Pro Ala Ser Ala Ser Gln Ser Ala Gly Ile Thr Gly Val 
            20                  25                  30          


Asn His Arg Ala Gln Pro Gly Leu Asn Val Ser Val Asp Lys Phe Thr 
        35                  40                  45              


Ala Met Ser Ser His Phe Thr Gln Asp Leu Leu Pro Glu Gln Gly Ile 
    50                  55                  60                  


Gln Asp Ala Phe Pro Lys Arg Ile Leu Arg Gly Tyr Gly Asn Cys Gly 
65                  70                  75                  80  


Leu Asp Asn Leu Tyr Leu Arg Lys Asp Trp Glu Ser Leu Asp Glu Cys 
                85                  90                  95      


Lys Leu Gln Lys Asp Tyr Asn Gly Leu Asn Gln Cys Ser Ser Thr Thr 
            100                 105                 110         


His Ser Lys Ile Phe Gln Tyr Asn Lys Tyr Val Lys Ile Phe Asp Asn 
        115                 120                 125             


Phe Ser Asn Leu His Arg Arg Asn Ile Ser Asn Thr Gly Glu Lys Pro 
    130                 135                 140                 


Phe Lys Cys Gln Glu Cys Gly Lys Ser Phe Gln Met Leu Ser Phe Leu 
145                 150                 155                 160 


Thr Glu His Gln Lys Ile His Thr Gly Lys Lys Phe Gln Lys Cys Gly 
                165                 170                 175     


Glu Cys Gly Lys Thr Phe Ile Gln Cys Ser His Phe Thr Glu Pro Glu 
            180                 185                 190         


Asn Ile Asp Thr Gly Glu Lys Pro Tyr Lys Cys Gln Glu Cys Asn Asn 
        195                 200                 205             


Val Ile Lys Thr Cys Ser Val Leu Thr Lys Asn Arg Ile Tyr Ala Gly 
    210                 215                 220                 


Gly Glu His Tyr Arg Cys Glu Glu Phe Gly Lys Val Phe Asn Gln Cys 
225                 230                 235                 240 


Ser His Leu Thr Glu His Glu His Gly Thr Glu Glu Lys Pro Cys Lys 
                245                 250                 255     


Tyr Glu Glu Cys Ser Ser Val Phe Ile Ser Cys Ser Ser Leu Ser Asn 
            260                 265                 270         


Gln Gln Met Ile Leu Ala Gly Glu Lys Leu Ser Lys Cys Glu Thr Trp 
        275                 280                 285             


Tyr Lys Gly Phe Asn His Ser Pro Asn Pro Ser Lys His Gln Arg Asn 
    290                 295                 300                 


Glu Ile Gly Gly Lys Pro Phe Lys Cys Glu Glu Cys Asp Ser Ile Phe 
305                 310                 315                 320 


Lys Trp Phe Ser Asp Leu Thr Lys His Lys Arg Ile His Thr Gly Glu 
                325                 330                 335     


Lys Pro Tyr Lys Cys Asp Glu Cys Gly Lys Ala Tyr Thr Gln Ser Ser 
            340                 345                 350         


His Leu Ser Glu His Arg Arg Ile His Thr Gly Glu Lys Pro Tyr Gln 
        355                 360                 365             


Cys Glu Glu Cys Gly Lys Val Phe Arg Thr Cys Ser Ser Leu Ser Asn 
    370                 375                 380                 


His Lys Arg Thr His Ser Glu Glu Lys Pro Tyr Thr Cys Glu Glu Cys 
385                 390                 395                 400 


Gly Asn Ile Phe Lys Gln Leu Ser Asp Leu Thr Lys His Lys Lys Thr 
                405                 410                 415     


His Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly Lys Asn Phe 
            420                 425                 430         


Thr Gln Ser Ser Asn Leu Ile Val His Lys Arg Ile His Thr Gly Glu 
        435                 440                 445             


Lys Pro Tyr Lys Cys Glu Glu Cys Gly Arg Val Phe Met Trp Phe Ser 
    450                 455                 460                 


Asp Ile Thr Lys His Lys Lys Thr His Thr Gly Glu Lys Pro Tyr Lys 
465                 470                 475                 480 


Cys Asp Glu Cys Gly Lys Asn Phe Thr Gln Ser Ser Asn Leu Ile Val 
                485                 490                 495     


His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Lys Cys 
            500                 505                 510         


Gly Lys Ala Phe Thr Gln Phe Ser His Leu Thr Val His Glu Ser Ile 
        515                 520                 525             


His Thr 
    530 

<210>  2666
<211>  2880
<212>  DNA
<213>  Homo sapiens

<400>  2666
aatcaggcac atgtctggag aggagaggac ggcttccggg atctagcggg gcctttgtcc     60

cgacagagct ccacttcctg tccccgcggc tctgtgtccc ctgctagccg taggtcgtgt    120

gacccgcagg caccgggaga tccagaagtg aaacgccagg ctctctggag gccaggagat    180

ggtgtgattt gtccagagaa tctttcctaa gaggaaatcc cagagaagca ggagaaagag    240

aaagaaatgg ctggtgctca gactctgttg acgttcaggg atgtggccat agaattctcc    300

ctggaggagt ggaaatgcct ggacctcgct cagcagaatt tgtacaggga tgtgatgttg    360

gagaactaca gaaacttgtt ctccgttggt ctcactgtct gtaagccagg cctgatcacc    420

tgcctggagc aacgaaaaga gccctggaat gtgaagagac aggaggcagc agacggacat    480

ccagagatgg gatttcacca tgctactcag gcttgtcttg aactcctggg ctcaagcgat    540

ctgcctgcct cagcctccca aagtgctggg attacaggtg tgaaccaccg tgcccagcca    600

ggcctcaatg tttctgtgga caaattcact gcactgtgct cacctggggt gctgcaaact    660

gtgaaatggt ttttagagtt cagatgcatc ttctcactag ctatgtcttc tcattttacc    720

caagaccttc tgccagagca gggcatacaa gatgcattcc caaaaagaat actgagagga    780

tatggaaatt gtggccttga taatttatat ttaaggaaag actgggaaag tttagatgag    840

tgtaagttgc aaaaagatta taatggactt aaccaatgtt catcaactac ccatagcaaa    900

atctttcaat ataataaata tgttaaaatc tttgataact tttcaaattt acatagacgt    960

aatataagta atactggaga gaaacctttc aaatgtcaag aatgtggcaa atcctttcaa   1020

atgctctcat tcctaactga acatcagaaa attcacactg gaaaaaaatt ccaaaaatgt   1080

ggagaatgtg gcaaaacctt tatccagtgc tcacacttta ctgaacctga gaacattgac   1140

actggagaga aaccttacaa gtgtcaagaa tgtaacaacg tcattaaaac ttgctcagtc   1200

cttactaaaa atagaattta tgccggaggg gaacattaca gatgtgaaga atttggcaaa   1260

gtatttaacc agtgctccca ccttactgaa catgagcatg gtactgagga aaaaccctgc   1320

aaatatgaag agtgcagcag tgtctttatc tcttgctcaa gcctttctaa tcaacagatg   1380

attcttgctg gagagaagct ctccaaatgt gaaacatggt acaaaggttt taaccacagc   1440

ccaaatcctt ccaaacacca gagaaatgag attggaggga aacctttcaa atgtgaggaa   1500

tgtgacagca tcttcaagtg gttctcagac cttactaaac ataagagaat tcacactggt   1560

gagaaaccat acaaatgtga cgaatgtggg aaagcctata cacagtcctc acacctcagt   1620

gaacacagga ggattcacac cggagagaaa ccctaccaat gtgaagaatg tgggaaggtc   1680

ttcagaactt gctcaagcct ttctaaccat aagagaactc attctgaaga aaaaccctac   1740

acgtgtgaag aatgtggcaa catctttaag cagttatcag acctcactaa gcataagaaa   1800

acccatactg gagagaagcc ctacaaatgt gacgaatgtg gaaaaaactt tacccagtcc   1860

tccaacctta ttgtacataa gagaattcat actggagaga aaccctacaa gtgtgaagaa   1920

tgtggcagag tcttcatgtg gttctcagac attaccaaac ataagaaaac ccatactgga   1980

gagaaaccct acaaatgtga cgaatgtgga aaaaacttta cccagtcctc aaaccttatt   2040

gtacataaga gaattcatac tggagagaaa ccctacaagt gtgaaaagtg tggcaaagcc   2100

ttcacccagt tctcacacct gactgtacat gaaagcattc atacttgaga aaaaaataaa   2160

caaatataaa aataggcaaa gccgttagta tctgctcgca tcccacttta catcagagtt   2220

cagacttaat aaagttatca taaatgtaat tactattgaa agacctttca tgaaatataa   2280

gtctccagag cacacaagag tatttcttct gaaaaaaatg ttacaattat actagatgga   2340

agacttgcat cagttgctta aactttcaga aaatttgtag agaaacccaa caaatctcat   2400

aaatgtggaa taacatttgt tcaaaaatga tagcttagaa aacactagag ttcatactaa   2460

aagatatttt gcaaatacac taaatgggaa aaataagcaa ggacacgttc agaaatgaca   2520

ctgaatccct gtgttgagtc tacagagaca tctagactta aaatagatca tttatattta   2580

agtttaaaag gaggatgaga ctgagttttt gtagagttat aattacattc aaaatatact   2640

tttttgcatt gaaaaaatgt taaatttttg aaaagcgaat attgatgtca ttctattctc   2700

aaatcagtag atgctgtgtc ttcatttcta gtgctgatgt gaaaacacat ggtcagttgt   2760

tgctgcgtca gagatatgag aaattctttt ctcttaggtg tgcatcactg atatacttgt   2820

ccgtgaaagg tgaaagacac tgaaatgtaa gatgcgtgag taaaatcttg gtagagaggc   2880


<210>  2667
<211>  633
<212>  PRT
<213>  Homo sapiens

<400>  2667


Met Ala Gly Ala Gln Thr Leu Leu Thr Phe Arg Asp Val Ala Ile Glu 
1               5                   10                  15      


Phe Ser Leu Glu Glu Trp Lys Cys Leu Asp Leu Ala Gln Gln Asn Leu 
            20                  25                  30          


Tyr Arg Asp Val Met Leu Glu Asn Tyr Arg Asn Leu Phe Ser Val Gly 
        35                  40                  45              


Leu Thr Val Cys Lys Pro Gly Leu Ile Thr Cys Leu Glu Gln Arg Lys 
    50                  55                  60                  


Glu Pro Trp Asn Val Lys Arg Gln Glu Ala Ala Asp Gly His Pro Glu 
65                  70                  75                  80  


Met Gly Phe His His Ala Thr Gln Ala Cys Leu Glu Leu Leu Gly Ser 
                85                  90                  95      


Ser Asp Leu Pro Ala Ser Ala Ser Gln Ser Ala Gly Ile Thr Gly Val 
            100                 105                 110         


Asn His Arg Ala Gln Pro Gly Leu Asn Val Ser Val Asp Lys Phe Thr 
        115                 120                 125             


Ala Leu Cys Ser Pro Gly Val Leu Gln Thr Val Lys Trp Phe Leu Glu 
    130                 135                 140                 


Phe Arg Cys Ile Phe Ser Leu Ala Met Ser Ser His Phe Thr Gln Asp 
145                 150                 155                 160 


Leu Leu Pro Glu Gln Gly Ile Gln Asp Ala Phe Pro Lys Arg Ile Leu 
                165                 170                 175     


Arg Gly Tyr Gly Asn Cys Gly Leu Asp Asn Leu Tyr Leu Arg Lys Asp 
            180                 185                 190         


Trp Glu Ser Leu Asp Glu Cys Lys Leu Gln Lys Asp Tyr Asn Gly Leu 
        195                 200                 205             


Asn Gln Cys Ser Ser Thr Thr His Ser Lys Ile Phe Gln Tyr Asn Lys 
    210                 215                 220                 


Tyr Val Lys Ile Phe Asp Asn Phe Ser Asn Leu His Arg Arg Asn Ile 
225                 230                 235                 240 


Ser Asn Thr Gly Glu Lys Pro Phe Lys Cys Gln Glu Cys Gly Lys Ser 
                245                 250                 255     


Phe Gln Met Leu Ser Phe Leu Thr Glu His Gln Lys Ile His Thr Gly 
            260                 265                 270         


Lys Lys Phe Gln Lys Cys Gly Glu Cys Gly Lys Thr Phe Ile Gln Cys 
        275                 280                 285             


Ser His Phe Thr Glu Pro Glu Asn Ile Asp Thr Gly Glu Lys Pro Tyr 
    290                 295                 300                 


Lys Cys Gln Glu Cys Asn Asn Val Ile Lys Thr Cys Ser Val Leu Thr 
305                 310                 315                 320 


Lys Asn Arg Ile Tyr Ala Gly Gly Glu His Tyr Arg Cys Glu Glu Phe 
                325                 330                 335     


Gly Lys Val Phe Asn Gln Cys Ser His Leu Thr Glu His Glu His Gly 
            340                 345                 350         


Thr Glu Glu Lys Pro Cys Lys Tyr Glu Glu Cys Ser Ser Val Phe Ile 
        355                 360                 365             


Ser Cys Ser Ser Leu Ser Asn Gln Gln Met Ile Leu Ala Gly Glu Lys 
    370                 375                 380                 


Leu Ser Lys Cys Glu Thr Trp Tyr Lys Gly Phe Asn His Ser Pro Asn 
385                 390                 395                 400 


Pro Ser Lys His Gln Arg Asn Glu Ile Gly Gly Lys Pro Phe Lys Cys 
                405                 410                 415     


Glu Glu Cys Asp Ser Ile Phe Lys Trp Phe Ser Asp Leu Thr Lys His 
            420                 425                 430         


Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly 
        435                 440                 445             


Lys Ala Tyr Thr Gln Ser Ser His Leu Ser Glu His Arg Arg Ile His 
    450                 455                 460                 


Thr Gly Glu Lys Pro Tyr Gln Cys Glu Glu Cys Gly Lys Val Phe Arg 
465                 470                 475                 480 


Thr Cys Ser Ser Leu Ser Asn His Lys Arg Thr His Ser Glu Glu Lys 
                485                 490                 495     


Pro Tyr Thr Cys Glu Glu Cys Gly Asn Ile Phe Lys Gln Leu Ser Asp 
            500                 505                 510         


Leu Thr Lys His Lys Lys Thr His Thr Gly Glu Lys Pro Tyr Lys Cys 
        515                 520                 525             


Asp Glu Cys Gly Lys Asn Phe Thr Gln Ser Ser Asn Leu Ile Val His 
    530                 535                 540                 


Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly 
545                 550                 555                 560 


Arg Val Phe Met Trp Phe Ser Asp Ile Thr Lys His Lys Lys Thr His 
                565                 570                 575     


Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly Lys Asn Phe Thr 
            580                 585                 590         


Gln Ser Ser Asn Leu Ile Val His Lys Arg Ile His Thr Gly Glu Lys 
        595                 600                 605             


Pro Tyr Lys Cys Glu Lys Cys Gly Lys Ala Phe Thr Gln Phe Ser His 
    610                 615                 620                 


Leu Thr Val His Glu Ser Ile His Thr 
625                 630             

<210>  2668
<211>  3164
<212>  DNA
<213>  Homo sapiens

<400>  2668
aatcaggcac atgtctggag aggagaggac ggcttccggg atctagcggg gcctttgtcc     60

cgacagagct ccacttcctg tccccgcggc tctgtgtccc ctgctagccg taggtcgtgt    120

gacccgcagg caccgggaga tccagaagtg aaacgccagg ctctctggag gccaggagat    180

ggcacagaca ccttaccaga atgtctttgg tttgaggttc cactttggaa acttgacagg    240

gtgatttgct ctcagccacc ctctggactt tttcctcagt ttcagtattg tccagggata    300

acacaggatg cccaccatgg ccatgtctgc tggagcatct agtgaatttc aggccctggg    360

ttatttctca gaggacagcc tgaggtatga agtgtggcct ctccagggag cagctggatg    420

ccctgggctg agagaaatct cctggtctac tcttcctcta aagaggtgtg atttgtccag    480

agaatctttc ctaagaggaa atcccagaga agcaggagaa agagaaagaa atggctggtg    540

ctcagactct gttgacgttc agggatgtgg ccatagaatt ctccctggag gagtggaaat    600

gcctggacct cgctcagcag aatttgtaca gggatgtgat gttggagaac tacagaaact    660

tgttctccgt tggtctcact gtctgtaagc caggcctgat cacctgcctg gagcaacgaa    720

aagagccctg gaatgtgaag agacaggagg cagcagacgg acatccagag atgggatttc    780

accatgctac tcaggcttgt cttgaactcc tgggctcaag cgatctgcct gcctcagcct    840

cccaaagtgc tgggattaca ggtgtgaacc accgtgccca gccaggcctc aatgtttctg    900

tggacaaatt cactgcactg tgctcacctg gggtgctgca aactgtgaaa tggtttttag    960

agttcagatg catcttctca ctagctatgt cttctcattt tacccaagac cttctgccag   1020

agcagggcat acaagatgca ttcccaaaaa gaatactgag aggatatgga aattgtggcc   1080

ttgataattt atatttaagg aaagactggg aaagtttaga tgagtgtaag ttgcaaaaag   1140

attataatgg acttaaccaa tgttcatcaa ctacccatag caaaatcttt caatataata   1200

aatatgttaa aatctttgat aacttttcaa atttacatag acgtaatata agtaatactg   1260

gagagaaacc tttcaaatgt caagaatgtg gcaaatcctt tcaaatgctc tcattcctaa   1320

ctgaacatca gaaaattcac actggaaaaa aattccaaaa atgtggagaa tgtggcaaaa   1380

cctttatcca gtgctcacac tttactgaac ctgagaacat tgacactgga gagaaacctt   1440

acaagtgtca agaatgtaac aacgtcatta aaacttgctc agtccttact aaaaatagaa   1500

tttatgccgg aggggaacat tacagatgtg aagaatttgg caaagtattt aaccagtgct   1560

cccaccttac tgaacatgag catggtactg aggaaaaacc ctgcaaatat gaagagtgca   1620

gcagtgtctt tatctcttgc tcaagccttt ctaatcaaca gatgattctt gctggagaga   1680

agctctccaa atgtgaaaca tggtacaaag gttttaacca cagcccaaat ccttccaaac   1740

accagagaaa tgagattgga gggaaacctt tcaaatgtga ggaatgtgac agcatcttca   1800

agtggttctc agaccttact aaacataaga gaattcacac tggtgagaaa ccatacaaat   1860

gtgacgaatg tgggaaagcc tatacacagt cctcacacct cagtgaacac aggaggattc   1920

acaccggaga gaaaccctac caatgtgaag aatgtgggaa ggtcttcaga acttgctcaa   1980

gcctttctaa ccataagaga actcattctg aagaaaaacc ctacacgtgt gaagaatgtg   2040

gcaacatctt taagcagtta tcagacctca ctaagcataa gaaaacccat actggagaga   2100

agccctacaa atgtgacgaa tgtggaaaaa actttaccca gtcctccaac cttattgtac   2160

ataagagaat tcatactgga gagaaaccct acaagtgtga agaatgtggc agagtcttca   2220

tgtggttctc agacattacc aaacataaga aaacccatac tggagagaaa ccctacaaat   2280

gtgacgaatg tggaaaaaac tttacccagt cctcaaacct tattgtacat aagagaattc   2340

atactggaga gaaaccctac aagtgtgaaa agtgtggcaa agccttcacc cagttctcac   2400

acctgactgt acatgaaagc attcatactt gagaaaaaaa taaacaaata taaaaatagg   2460

caaagccgtt agtatctgct cgcatcccac tttacatcag agttcagact taataaagtt   2520

atcataaatg taattactat tgaaagacct ttcatgaaat ataagtctcc agagcacaca   2580

agagtatttc ttctgaaaaa aatgttacaa ttatactaga tggaagactt gcatcagttg   2640

cttaaacttt cagaaaattt gtagagaaac ccaacaaatc tcataaatgt ggaataacat   2700

ttgttcaaaa atgatagctt agaaaacact agagttcata ctaaaagata ttttgcaaat   2760

acactaaatg ggaaaaataa gcaaggacac gttcagaaat gacactgaat ccctgtgttg   2820

agtctacaga gacatctaga cttaaaatag atcatttata tttaagttta aaaggaggat   2880

gagactgagt ttttgtagag ttataattac attcaaaata tacttttttg cattgaaaaa   2940

atgttaaatt tttgaaaagc gaatattgat gtcattctat tctcaaatca gtagatgctg   3000

tgtcttcatt tctagtgctg atgtgaaaac acatggtcag ttgttgctgc gtcagagata   3060

tgagaaattc ttttctctta ggtgtgcatc actgatatac ttgtccgtga aaggtgaaag   3120

acactgaaat gtaagatgcg tgagtaaaat cttggtagag aggc                    3164


<210>  2669
<211>  633
<212>  PRT
<213>  Homo sapiens

<400>  2669


Met Ala Gly Ala Gln Thr Leu Leu Thr Phe Arg Asp Val Ala Ile Glu 
1               5                   10                  15      


Phe Ser Leu Glu Glu Trp Lys Cys Leu Asp Leu Ala Gln Gln Asn Leu 
            20                  25                  30          


Tyr Arg Asp Val Met Leu Glu Asn Tyr Arg Asn Leu Phe Ser Val Gly 
        35                  40                  45              


Leu Thr Val Cys Lys Pro Gly Leu Ile Thr Cys Leu Glu Gln Arg Lys 
    50                  55                  60                  


Glu Pro Trp Asn Val Lys Arg Gln Glu Ala Ala Asp Gly His Pro Glu 
65                  70                  75                  80  


Met Gly Phe His His Ala Thr Gln Ala Cys Leu Glu Leu Leu Gly Ser 
                85                  90                  95      


Ser Asp Leu Pro Ala Ser Ala Ser Gln Ser Ala Gly Ile Thr Gly Val 
            100                 105                 110         


Asn His Arg Ala Gln Pro Gly Leu Asn Val Ser Val Asp Lys Phe Thr 
        115                 120                 125             


Ala Leu Cys Ser Pro Gly Val Leu Gln Thr Val Lys Trp Phe Leu Glu 
    130                 135                 140                 


Phe Arg Cys Ile Phe Ser Leu Ala Met Ser Ser His Phe Thr Gln Asp 
145                 150                 155                 160 


Leu Leu Pro Glu Gln Gly Ile Gln Asp Ala Phe Pro Lys Arg Ile Leu 
                165                 170                 175     


Arg Gly Tyr Gly Asn Cys Gly Leu Asp Asn Leu Tyr Leu Arg Lys Asp 
            180                 185                 190         


Trp Glu Ser Leu Asp Glu Cys Lys Leu Gln Lys Asp Tyr Asn Gly Leu 
        195                 200                 205             


Asn Gln Cys Ser Ser Thr Thr His Ser Lys Ile Phe Gln Tyr Asn Lys 
    210                 215                 220                 


Tyr Val Lys Ile Phe Asp Asn Phe Ser Asn Leu His Arg Arg Asn Ile 
225                 230                 235                 240 


Ser Asn Thr Gly Glu Lys Pro Phe Lys Cys Gln Glu Cys Gly Lys Ser 
                245                 250                 255     


Phe Gln Met Leu Ser Phe Leu Thr Glu His Gln Lys Ile His Thr Gly 
            260                 265                 270         


Lys Lys Phe Gln Lys Cys Gly Glu Cys Gly Lys Thr Phe Ile Gln Cys 
        275                 280                 285             


Ser His Phe Thr Glu Pro Glu Asn Ile Asp Thr Gly Glu Lys Pro Tyr 
    290                 295                 300                 


Lys Cys Gln Glu Cys Asn Asn Val Ile Lys Thr Cys Ser Val Leu Thr 
305                 310                 315                 320 


Lys Asn Arg Ile Tyr Ala Gly Gly Glu His Tyr Arg Cys Glu Glu Phe 
                325                 330                 335     


Gly Lys Val Phe Asn Gln Cys Ser His Leu Thr Glu His Glu His Gly 
            340                 345                 350         


Thr Glu Glu Lys Pro Cys Lys Tyr Glu Glu Cys Ser Ser Val Phe Ile 
        355                 360                 365             


Ser Cys Ser Ser Leu Ser Asn Gln Gln Met Ile Leu Ala Gly Glu Lys 
    370                 375                 380                 


Leu Ser Lys Cys Glu Thr Trp Tyr Lys Gly Phe Asn His Ser Pro Asn 
385                 390                 395                 400 


Pro Ser Lys His Gln Arg Asn Glu Ile Gly Gly Lys Pro Phe Lys Cys 
                405                 410                 415     


Glu Glu Cys Asp Ser Ile Phe Lys Trp Phe Ser Asp Leu Thr Lys His 
            420                 425                 430         


Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly 
        435                 440                 445             


Lys Ala Tyr Thr Gln Ser Ser His Leu Ser Glu His Arg Arg Ile His 
    450                 455                 460                 


Thr Gly Glu Lys Pro Tyr Gln Cys Glu Glu Cys Gly Lys Val Phe Arg 
465                 470                 475                 480 


Thr Cys Ser Ser Leu Ser Asn His Lys Arg Thr His Ser Glu Glu Lys 
                485                 490                 495     


Pro Tyr Thr Cys Glu Glu Cys Gly Asn Ile Phe Lys Gln Leu Ser Asp 
            500                 505                 510         


Leu Thr Lys His Lys Lys Thr His Thr Gly Glu Lys Pro Tyr Lys Cys 
        515                 520                 525             


Asp Glu Cys Gly Lys Asn Phe Thr Gln Ser Ser Asn Leu Ile Val His 
    530                 535                 540                 


Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly 
545                 550                 555                 560 


Arg Val Phe Met Trp Phe Ser Asp Ile Thr Lys His Lys Lys Thr His 
                565                 570                 575     


Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly Lys Asn Phe Thr 
            580                 585                 590         


Gln Ser Ser Asn Leu Ile Val His Lys Arg Ile His Thr Gly Glu Lys 
        595                 600                 605             


Pro Tyr Lys Cys Glu Lys Cys Gly Lys Ala Phe Thr Gln Phe Ser His 
    610                 615                 620                 


Leu Thr Val His Glu Ser Ile His Thr 
625                 630             

<210>  2670
<211>  2780
<212>  DNA
<213>  Homo sapiens

<400>  2670
aatcaggcac atgtctggag aggagaggac ggcttccggg atctagcggg gcctttgtcc     60

cgacagagct ccacttcctg tccccgcggc tctgtgtccc ctgctagccg taggtcgtgt    120

gacccgcagg caccgggaga tccagaagtg aaacgccagg ctctctggag gccaggagat    180

ggcacagaca ccttaccaga atgtctttgg tttgaggttc cactttggaa acttgacagg    240

gtgatttgct ctcagccacc ctctggactt tttcctcagt ttcagtattg tccagggata    300

acacaggatg cccaccatgg ccatgtctgc tggagcatct agtgaatttc aggccctggg    360

ttatttctca gaggacagcc tgaggtatga agtgtggcct ctccagggag cagctggatg    420

ccctgggctg agagaaatct cctggtctac tcttcctcta aagaggtgtg atttgtccag    480

agaatctttc ctaagaggaa atcccagaga agcaggagaa agagaaagaa atggctggtg    540

ctcagactct gttgacgttc agggatgtgg ccatagaatt ctccctggag gagtggaaat    600

gcctggacct cgctcagcag aatttgtaca gggatgtgat gttggagaac tacagaaact    660

tgttctccgt tggtctcact gtctgtaagc caggcctgat cacctgcctg gagcaacgaa    720

aagagccctg gaatgtgaag agacaggagg cagcagacgg acatccagct atgtcttctc    780

attttaccca agaccttctg ccagagcagg gcatacaaga tgcattccca aaaagaatac    840

tgagaggata tggaaattgt ggccttgata atttatattt aaggaaagac tgggaaagtt    900

tagatgagtg taagttgcaa aaagattata atggacttaa ccaatgttca tcaactaccc    960

atagcaaaat ctttcaatat aataaatatg ttaaaatctt tgataacttt tcaaatttac   1020

atagacgtaa tataagtaat actggagaga aacctttcaa atgtcaagaa tgtggcaaat   1080

cctttcaaat gctctcattc ctaactgaac atcagaaaat tcacactgga aaaaaattcc   1140

aaaaatgtgg agaatgtggc aaaaccttta tccagtgctc acactttact gaacctgaga   1200

acattgacac tggagagaaa ccttacaagt gtcaagaatg taacaacgtc attaaaactt   1260

gctcagtcct tactaaaaat agaatttatg ccggagggga acattacaga tgtgaagaat   1320

ttggcaaagt atttaaccag tgctcccacc ttactgaaca tgagcatggt actgaggaaa   1380

aacctttcaa atgtgaggaa tgtgacagca tcttcaagtg gttctcagac cttactaaac   1440

ataagagaat tcacactggt gagaaaccat acaaatgtga cgaatgtggg aaagcctata   1500

cacagtcctc acacctcagt gaacacagga ggattcacac cggagagaaa ccctaccaat   1560

gtgaagaatg tgggaaggtc ttcagaactt gctcaagcct ttctaaccat aagagaactc   1620

attctgaaga aaaaccctac acgtgtgaag aatgtggcaa catctttaag cagttatcag   1680

acctcactaa gcataagaaa acccatactg gagagaagcc ctacaaatgt gacgaatgtg   1740

gaaaaaactt tacccagtcc tccaacctta ttgtacataa gagaattcat actggagaga   1800

aaccctacaa gtgtgaagaa tgtggcagag tcttcatgtg gttctcagac attaccaaac   1860

ataagaaaac ccatactgga gagaaaccct acaaatgtga cgaatgtgga aaaaacttta   1920

cccagtcctc aaaccttatt gtacataaga gaattcatac tggagagaaa ccctacaagt   1980

gtgaaaagtg tggcaaagcc ttcacccagt tctcacacct gactgtacat gaaagcattc   2040

atacttgaga aaaaaataaa caaatataaa aataggcaaa gccgttagta tctgctcgca   2100

tcccacttta catcagagtt cagacttaat aaagttatca taaatgtaat tactattgaa   2160

agacctttca tgaaatataa gtctccagag cacacaagag tatttcttct gaaaaaaatg   2220

ttacaattat actagatgga agacttgcat cagttgctta aactttcaga aaatttgtag   2280

agaaacccaa caaatctcat aaatgtggaa taacatttgt tcaaaaatga tagcttagaa   2340

aacactagag ttcatactaa aagatatttt gcaaatacac taaatgggaa aaataagcaa   2400

ggacacgttc agaaatgaca ctgaatccct gtgttgagtc tacagagaca tctagactta   2460

aaatagatca tttatattta agtttaaaag gaggatgaga ctgagttttt gtagagttat   2520

aattacattc aaaatatact tttttgcatt gaaaaaatgt taaatttttg aaaagcgaat   2580

attgatgtca ttctattctc aaatcagtag atgctgtgtc ttcatttcta gtgctgatgt   2640

gaaaacacat ggtcagttgt tgctgcgtca gagatatgag aaattctttt ctcttaggtg   2700

tgcatcactg atatacttgt ccgtgaaagg tgaaagacac tgaaatgtaa gatgcgtgag   2760

taaaatcttg gtagagaggc                                               2780


<210>  2671
<211>  505
<212>  PRT
<213>  Homo sapiens

<400>  2671


Met Ala Gly Ala Gln Thr Leu Leu Thr Phe Arg Asp Val Ala Ile Glu 
1               5                   10                  15      


Phe Ser Leu Glu Glu Trp Lys Cys Leu Asp Leu Ala Gln Gln Asn Leu 
            20                  25                  30          


Tyr Arg Asp Val Met Leu Glu Asn Tyr Arg Asn Leu Phe Ser Val Gly 
        35                  40                  45              


Leu Thr Val Cys Lys Pro Gly Leu Ile Thr Cys Leu Glu Gln Arg Lys 
    50                  55                  60                  


Glu Pro Trp Asn Val Lys Arg Gln Glu Ala Ala Asp Gly His Pro Ala 
65                  70                  75                  80  


Met Ser Ser His Phe Thr Gln Asp Leu Leu Pro Glu Gln Gly Ile Gln 
                85                  90                  95      


Asp Ala Phe Pro Lys Arg Ile Leu Arg Gly Tyr Gly Asn Cys Gly Leu 
            100                 105                 110         


Asp Asn Leu Tyr Leu Arg Lys Asp Trp Glu Ser Leu Asp Glu Cys Lys 
        115                 120                 125             


Leu Gln Lys Asp Tyr Asn Gly Leu Asn Gln Cys Ser Ser Thr Thr His 
    130                 135                 140                 


Ser Lys Ile Phe Gln Tyr Asn Lys Tyr Val Lys Ile Phe Asp Asn Phe 
145                 150                 155                 160 


Ser Asn Leu His Arg Arg Asn Ile Ser Asn Thr Gly Glu Lys Pro Phe 
                165                 170                 175     


Lys Cys Gln Glu Cys Gly Lys Ser Phe Gln Met Leu Ser Phe Leu Thr 
            180                 185                 190         


Glu His Gln Lys Ile His Thr Gly Lys Lys Phe Gln Lys Cys Gly Glu 
        195                 200                 205             


Cys Gly Lys Thr Phe Ile Gln Cys Ser His Phe Thr Glu Pro Glu Asn 
    210                 215                 220                 


Ile Asp Thr Gly Glu Lys Pro Tyr Lys Cys Gln Glu Cys Asn Asn Val 
225                 230                 235                 240 


Ile Lys Thr Cys Ser Val Leu Thr Lys Asn Arg Ile Tyr Ala Gly Gly 
                245                 250                 255     


Glu His Tyr Arg Cys Glu Glu Phe Gly Lys Val Phe Asn Gln Cys Ser 
            260                 265                 270         


His Leu Thr Glu His Glu His Gly Thr Glu Glu Lys Pro Phe Lys Cys 
        275                 280                 285             


Glu Glu Cys Asp Ser Ile Phe Lys Trp Phe Ser Asp Leu Thr Lys His 
    290                 295                 300                 


Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly 
305                 310                 315                 320 


Lys Ala Tyr Thr Gln Ser Ser His Leu Ser Glu His Arg Arg Ile His 
                325                 330                 335     


Thr Gly Glu Lys Pro Tyr Gln Cys Glu Glu Cys Gly Lys Val Phe Arg 
            340                 345                 350         


Thr Cys Ser Ser Leu Ser Asn His Lys Arg Thr His Ser Glu Glu Lys 
        355                 360                 365             


Pro Tyr Thr Cys Glu Glu Cys Gly Asn Ile Phe Lys Gln Leu Ser Asp 
    370                 375                 380                 


Leu Thr Lys His Lys Lys Thr His Thr Gly Glu Lys Pro Tyr Lys Cys 
385                 390                 395                 400 


Asp Glu Cys Gly Lys Asn Phe Thr Gln Ser Ser Asn Leu Ile Val His 
                405                 410                 415     


Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly 
            420                 425                 430         


Arg Val Phe Met Trp Phe Ser Asp Ile Thr Lys His Lys Lys Thr His 
        435                 440                 445             


Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly Lys Asn Phe Thr 
    450                 455                 460                 


Gln Ser Ser Asn Leu Ile Val His Lys Arg Ile His Thr Gly Glu Lys 
465                 470                 475                 480 


Pro Tyr Lys Cys Glu Lys Cys Gly Lys Ala Phe Thr Gln Phe Ser His 
                485                 490                 495     


Leu Thr Val His Glu Ser Ile His Thr 
            500                 505 

<210>  2672
<211>  2721
<212>  DNA
<213>  Homo sapiens

<400>  2672
aatcaggcac atgtctggag aggagaggac ggcttccggg atctagcggg gcctttgtcc     60

cgacagagct ccacttcctg tccccgcggc tctgtgtccc ctgctagccg taggtcgtgt    120

gacccgcagg caccgggaga tccagaagtg aaacgccagg ctctctggag gccaggagat    180

ggtgtgattt gtccagagaa tctttcctaa gaggaaatcc cagagaagca ggagaaagag    240

aaagaaatgg ctggtgctca gactctgttg acgttcaggg atgtggccat agaattctcc    300

ctggaggagt ggaaatgcct ggacctcgct cagcagaatt tgtacaggga tgtgatgttg    360

gagaactaca gaaacttgtt ctccgttggt ctcactgtct gtaagccagg cctgatcacc    420

tgcctggagc aacgaaaaga gccctggaat gtgaagagac aggaggcagc agacggacat    480

ccaggtattt tctttgtggt taccatggaa attatataaa acatcttaaa gttacaacaa    540

gctatgtctt ctcattttac ccaagacctt ctgccagagc agggcataca agatgcattc    600

ccaaaaagaa tactgagagg atatggaaat tgtggccttg ataatttata tttaaggaaa    660

gactgggaaa gtttagatga gtgtaagttg caaaaagatt ataatggact taaccaatgt    720

tcatcaacta cccatagcaa aatctttcaa tataataaat atgttaaaat ctttgataac    780

ttttcaaatt tacatagacg taatataagt aatactggag agaaaccttt caaatgtcaa    840

gaatgtggca aatcctttca aatgctctca ttcctaactg aacatcagaa aattcacact    900

ggaaaaaaat tccaaaaatg tggagaatgt ggcaaaacct ttatccagtg ctcacacttt    960

actgaacctg agaacattga cactggagag aaaccttaca agtgtcaaga atgtaacaac   1020

gtcattaaaa cttgctcagt ccttactaaa aatagaattt atgccggagg ggaacattac   1080

agatgtgaag aatttggcaa agtatttaac cagtgctccc accttactga acatgagcat   1140

ggtactgagg aaaaaccctg caaatatgaa gagtgcagca gtgtctttat ctcttgctca   1200

agcctttcta atcaacagat gattcttgct ggagagaagc tctccaaatg tgaaacatgg   1260

tacaaaggtt ttaaccacag cccaaatcct tccaaacacc agagaaatga gattggaggg   1320

aaacctttca aatgtgagga atgtgacagc atcttcaagt ggttctcaga ccttactaaa   1380

cataagagaa ttcacactgg tgagaaacca tacaaatgtg acgaatgtgg gaaagcctat   1440

acacagtcct cacacctcag tgaacacagg aggattcaca ccggagagaa accctaccaa   1500

tgtgaagaat gtgggaaggt cttcagaact tgctcaagcc tttctaacca taagagaact   1560

cattctgaag aaaaacccta cacgtgtgaa gaatgtggca acatctttaa gcagttatca   1620

gacctcacta agcataagaa aacccatact ggagagaagc cctacaaatg tgacgaatgt   1680

ggaaaaaact ttacccagtc ctccaacctt attgtacata agagaattca tactggagag   1740

aaaccctaca agtgtgaaga atgtggcaga gtcttcatgt ggttctcaga cattaccaaa   1800

cataagaaaa cccatactgg agagaaaccc tacaaatgtg acgaatgtgg aaaaaacttt   1860

acccagtcct caaaccttat tgtacataag agaattcata ctggagagaa accctacaag   1920

tgtgaaaagt gtggcaaagc cttcacccag ttctcacacc tgactgtaca tgaaagcatt   1980

catacttgag aaaaaaataa acaaatataa aaataggcaa agccgttagt atctgctcgc   2040

atcccacttt acatcagagt tcagacttaa taaagttatc ataaatgtaa ttactattga   2100

aagacctttc atgaaatata agtctccaga gcacacaaga gtatttcttc tgaaaaaaat   2160

gttacaatta tactagatgg aagacttgca tcagttgctt aaactttcag aaaatttgta   2220

gagaaaccca acaaatctca taaatgtgga ataacatttg ttcaaaaatg atagcttaga   2280

aaacactaga gttcatacta aaagatattt tgcaaataca ctaaatggga aaaataagca   2340

aggacacgtt cagaaatgac actgaatccc tgtgttgagt ctacagagac atctagactt   2400

aaaatagatc atttatattt aagtttaaaa ggaggatgag actgagtttt tgtagagtta   2460

taattacatt caaaatatac ttttttgcat tgaaaaaatg ttaaattttt gaaaagcgaa   2520

tattgatgtc attctattct caaatcagta gatgctgtgt cttcatttct agtgctgatg   2580

tgaaaacaca tggtcagttg ttgctgcgtc agagatatga gaaattcttt tctcttaggt   2640

gtgcatcact gatatacttg tccgtgaaag gtgaaagaca ctgaaatgta agatgcgtga   2700

gtaaaatctt ggtagagagg c                                             2721


<210>  2673
<211>  90
<212>  PRT
<213>  Homo sapiens

<400>  2673


Met Ala Gly Ala Gln Thr Leu Leu Thr Phe Arg Asp Val Ala Ile Glu 
1               5                   10                  15      


Phe Ser Leu Glu Glu Trp Lys Cys Leu Asp Leu Ala Gln Gln Asn Leu 
            20                  25                  30          


Tyr Arg Asp Val Met Leu Glu Asn Tyr Arg Asn Leu Phe Ser Val Gly 
        35                  40                  45              


Leu Thr Val Cys Lys Pro Gly Leu Ile Thr Cys Leu Glu Gln Arg Lys 
    50                  55                  60                  


Glu Pro Trp Asn Val Lys Arg Gln Glu Ala Ala Asp Gly His Pro Gly 
65                  70                  75                  80  


Ile Phe Phe Val Val Thr Met Glu Ile Ile 
                85                  90  

<210>  2674
<211>  2963
<212>  DNA
<213>  Homo sapiens

<400>  2674
tggaaactgt ggttataatg tgtcttatgt ccctttttgt ttatactagt tgatgtgttg     60

agcttcttga tttttttgta tttttttctt acttttgaga atttctcagt aattatttcc    120

tttcatacct cagtttctca gtctgttttt catacttcat gtctttttat tggtatcctt    180

attttcctaa ttttacttag tttgctgttt tgccattttt actcattgag cattattcaa    240

atggtaattt tattttcttc agttaattta tgcatctcca tcattttagg gttgatttct    300

gaactttttt tatttctttg attatgccat gtgaccctaa tactttgtac atgtcatctt    360

tgactgagat tcaggcatta acaacaagcc tcctgccaca acctttataa tgtgcctttc    420

tcctggggtc atctaaaaca aataggccca gattctagag gcctcttaag cctgttctgg    480

gatgtgtctt gtgtggaatt gtgtgtgtat ttttcattta aagagggttt ctcagctttc    540

tttgtagtgc cctggaatca cacaatacac ttgtcgcctg gtgctgctgc tgcagccttc    600

ctaccgctgt catgggtatt tcctttcggt ctcagcagac ccagcctgtc actcagagta    660

ccaccatttc tctcagcact ccgtgtcaca gggggcagaa accaatcttt gccaaagctt    720

caaaaggcca aaagtaaaaa cacttgtgcc agtatttgct ttctcttttg aaggagaagc    780

caagagctga gggtgtactc ttaaaggcat gatgctatac tgcggaggag cgggggctgc    840

agtgggtaaa cgtaacagac tgtttttctt cttatctggc tcctagcact gtgctcacct    900

ggggtgctgc aaactgtgaa atggttttta gagttcagat gcatcttctc actagctatg    960

tcttctcatt ttacccaaga ccttctgcca gagcagggca tacaagatgc attcccaaaa   1020

agaatactga gaggatatgg aaattgtggc cttgataatt tatatttaag gaaagactgg   1080

gaaagtttag atgagtgtaa gttgcaaaaa gattataatg gacttaacca atgttcatca   1140

actacccata gcaaaatctt tcaatataat aaatatgtta aaatctttga taacttttca   1200

aatttacata gacgtaatat aagtaatact ggagagaaac ctttcaaatg tcaagaatgt   1260

ggcaaatcct ttcaaatgct ctcattccta actgaacatc agaaaattca cactggaaaa   1320

aaattccaaa aatgtggaga atgtggcaaa acctttatcc agtgctcaca ctttactgaa   1380

cctgagaaca ttgacactgg agagaaacct tacaagtgtc aagaatgtaa caacgtcatt   1440

aaaacttgct cagtccttac taaaaataga atttatgccg gaggggaaca ttacagatgt   1500

gaagaatttg gcaaagtatt taaccagtgc tcccacctta ctgaacatga gcatggtact   1560

gaggaaaaac cctgcaaata tgaagagtgc agcagtgtct ttatctcttg ctcaagcctt   1620

tctaatcaac agatgattct tgctggagag aagctctcca aatgtgaaac atggtacaaa   1680

ggttttaacc acagcccaaa tccttccaaa caccagagaa atgagattgg agggaaacct   1740

ttcaaatgtg aggaatgtga cagcatcttc aagtggttct cagaccttac taaacataag   1800

agaattcaca ctggtgagaa accatacaaa tgtgacgaat gtgggaaagc ctatacacag   1860

tcctcacacc tcagtgaaca caggaggatt cacaccggag agaaacccta ccaatgtgaa   1920

gaatgtggga aggtcttcag aacttgctca agcctttcta accataagag aactcattct   1980

gaagaaaaac cctacacgtg tgaagaatgt ggcaacatct ttaagcagtt atcagacctc   2040

actaagcata agaaaaccca tactggagag aagccctaca aatgtgacga atgtggaaaa   2100

aactttaccc agtcctccaa ccttattgta cataagagaa ttcatactgg agagaaaccc   2160

tacaagtgtg aagaatgtgg cagagtcttc atgtggttct cagacattac caaacataag   2220

aaaacccata ctggagagaa accctacaaa tgtgacgaat gtggaaaaaa ctttacccag   2280

tcctcaaacc ttattgtaca taagagaatt catactggag agaaacccta caagtgtgaa   2340

aagtgtggca aagccttcac ccagttctca cacctgactg tacatgaaag cattcatact   2400

tgagaaaaaa ataaacaaat ataaaaatag gcaaagccgt tagtatctgc tcgcatccca   2460

ctttacatca gagttcagac ttaataaagt tatcataaat gtaattacta ttgaaagacc   2520

tttcatgaaa tataagtctc cagagcacac aagagtattt cttctgaaaa aaatgttaca   2580

attatactag atggaagact tgcatcagtt gcttaaactt tcagaaaatt tgtagagaaa   2640

cccaacaaat ctcataaatg tggaataaca tttgttcaaa aatgatagct tagaaaacac   2700

tagagttcat actaaaagat attttgcaaa tacactaaat gggaaaaata agcaaggaca   2760

cgttcagaaa tgacactgaa tccctgtgtt gagtctacag agacatctag acttaaaata   2820

gatcatttat atttaagttt aaaaggagga tgagactgag tttttgtaga gttataatta   2880

cattcaaaat atactttttt gcattgaaaa aatgttaaat ttttgaaaag cgaatattga   2940

tgtcattcta ttctcaaatc agt                                           2963


<210>  2675
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  2675


Met Val Phe Arg Val Gln Met His Leu Leu Thr Ser Tyr Val Phe Ser 
1               5                   10                  15      


Phe Tyr Pro Arg Pro Ser Ala Arg Ala Gly His Thr Arg Cys Ile Pro 
            20                  25                  30          


Lys Lys Asn Thr Glu Arg Ile Trp Lys Leu Trp Pro 
        35                  40                  

<210>  2676
<211>  2454
<212>  DNA
<213>  Homo sapiens

<400>  2676
cagctgtagt ttgatcttag tttggtttta aattatttag catatgcctt ttgattgagt     60

agtttagttc ctaaataagc aatttactga aatgaaaaga tgtactttag ccattgtatt    120

ttttttactt gattcttgta gctttttctt tctctctttc ctttttgtgt cttgtacttt    180

gtataataag ctttgactct ttttaaattt tcttttgtgt gtcttatagg tattttcttt    240

gtggttacca tggaaattat ataaaacatc ttaaagttac aacaaggtat tttacactga    300

gatgggattt caccatgcta ctcaggcttg tcttgaactc ctgggctcaa gcgatctgcc    360

tgcctcagcc tcccaaagtg ctgggattac aggtgtgaac caccgtgccc agccaggcct    420

caatgtttct gtggacaaat tcactgctat gtcttctcat tttacccaag accttctgcc    480

agagcagggc atacaagatg cattcccaaa aagaatactg agaggatatg gaaattgtgg    540

ccttgataat ttatatttaa ggaaagactg ggaaagttta gatgagtgta agttgcaaaa    600

agattataat ggacttaacc aatgttcatc aactacccat agcaaaatct ttcaatataa    660

taaatatgtt aaaatctttg ataacttttc aaatttacat agacgtaata taagtaatac    720

tggagagaaa cctttcaaat gtcaagaatg tggcaaatcc tttcaaatgc tctcattcct    780

aactgaacat cagaaaattc acactggaaa aaaattccaa aaatgtggag aatgtggcaa    840

aacctttatc cagtgctcac actttactga acctgagaac attgacactg gagagaaacc    900

ttacaagtgt caagaatgta acaacgtcat taaaacttgc tcagtcctta ctaaaaatag    960

aatttatgcc ggaggggaac attacagatg tgaagaattt ggcaaagtat ttaaccagtg   1020

ctcccacctt actgaacatg agcatggtac tgaggaaaaa ccctgcaaat atgaagagtg   1080

cagcagtgtc tttatctctt gctcaagcct ttctaatcaa cagatgattc ttgctggaga   1140

gaagctctcc aaatgtgaaa catggtacaa aggttttaac cacagcccaa atccttccaa   1200

acaccagaga aatgagattg gagggaaacc tttcaaatgt gaggaatgtg acagcatctt   1260

caagtggttc tcagacctta ctaaacataa gagaattcac actggtgaga aaccatacaa   1320

atgtgacgaa tgtgggaaag cctatacaca gtcctcacac ctcagtgaac acaggaggat   1380

tcacaccgga gagaaaccct accaatgtga agaatgtggg aaggtcttca gaacttgctc   1440

aagcctttct aaccataaga gaactcattc tgaagaaaaa ccctacacgt gtgaagaatg   1500

tggcaacatc tttaagcagt tatcagacct cactaagcat aagaaaaccc atactggaga   1560

gaagccctac aaatgtgacg aatgtggaaa aaactttacc cagtcctcca accttattgt   1620

acataagaga attcatactg gagagaaacc ctacaagtgt gaagaatgtg gcagagtctt   1680

catgtggttc tcagacatta ccaaacataa gaaaacccat actggagaga aaccctacaa   1740

atgtgacgaa tgtggaaaaa actttaccca gtcctcaaac cttattgtac ataagagaat   1800

tcatactgga gagaaaccct acaagtgtga aaagtgtggc aaagccttca cccagttctc   1860

acacctgact gtacatgaaa gcattcatac ttgagaaaaa aataaacaaa tataaaaata   1920

ggcaaagccg ttagtatctg ctcgcatccc actttacatc agagttcaga cttaataaag   1980

ttatcataaa tgtaattact attgaaagac ctttcatgaa atataagtct ccagagcaca   2040

caagagtatt tcttctgaaa aaaatgttac aattatacta gatggaagac ttgcatcagt   2100

tgcttaaact ttcagaaaat ttgtagagaa acccaacaaa tctcataaat gtggaataac   2160

atttgttcaa aaatgatagc ttagaaaaca ctagagttca tactaaaaga tattttgcaa   2220

atacactaaa tgggaaaaat aagcaaggac acgttcagaa atgacactga atccctgtgt   2280

tgagtctaca gagacatcta gacttaaaat agatcattta tatttaagtt taaaaggagg   2340

atgagactga gtttttgtag agttataatt acattcaaaa tatacttttt tgcattgaaa   2400

aaatgttaaa tttttgaaaa gcgaatattg atgtcattct attctcaaat cagt         2454


<210>  2677
<211>  530
<212>  PRT
<213>  Homo sapiens

<400>  2677


Met Gly Phe His His Ala Thr Gln Ala Cys Leu Glu Leu Leu Gly Ser 
1               5                   10                  15      


Ser Asp Leu Pro Ala Ser Ala Ser Gln Ser Ala Gly Ile Thr Gly Val 
            20                  25                  30          


Asn His Arg Ala Gln Pro Gly Leu Asn Val Ser Val Asp Lys Phe Thr 
        35                  40                  45              


Ala Met Ser Ser His Phe Thr Gln Asp Leu Leu Pro Glu Gln Gly Ile 
    50                  55                  60                  


Gln Asp Ala Phe Pro Lys Arg Ile Leu Arg Gly Tyr Gly Asn Cys Gly 
65                  70                  75                  80  


Leu Asp Asn Leu Tyr Leu Arg Lys Asp Trp Glu Ser Leu Asp Glu Cys 
                85                  90                  95      


Lys Leu Gln Lys Asp Tyr Asn Gly Leu Asn Gln Cys Ser Ser Thr Thr 
            100                 105                 110         


His Ser Lys Ile Phe Gln Tyr Asn Lys Tyr Val Lys Ile Phe Asp Asn 
        115                 120                 125             


Phe Ser Asn Leu His Arg Arg Asn Ile Ser Asn Thr Gly Glu Lys Pro 
    130                 135                 140                 


Phe Lys Cys Gln Glu Cys Gly Lys Ser Phe Gln Met Leu Ser Phe Leu 
145                 150                 155                 160 


Thr Glu His Gln Lys Ile His Thr Gly Lys Lys Phe Gln Lys Cys Gly 
                165                 170                 175     


Glu Cys Gly Lys Thr Phe Ile Gln Cys Ser His Phe Thr Glu Pro Glu 
            180                 185                 190         


Asn Ile Asp Thr Gly Glu Lys Pro Tyr Lys Cys Gln Glu Cys Asn Asn 
        195                 200                 205             


Val Ile Lys Thr Cys Ser Val Leu Thr Lys Asn Arg Ile Tyr Ala Gly 
    210                 215                 220                 


Gly Glu His Tyr Arg Cys Glu Glu Phe Gly Lys Val Phe Asn Gln Cys 
225                 230                 235                 240 


Ser His Leu Thr Glu His Glu His Gly Thr Glu Glu Lys Pro Cys Lys 
                245                 250                 255     


Tyr Glu Glu Cys Ser Ser Val Phe Ile Ser Cys Ser Ser Leu Ser Asn 
            260                 265                 270         


Gln Gln Met Ile Leu Ala Gly Glu Lys Leu Ser Lys Cys Glu Thr Trp 
        275                 280                 285             


Tyr Lys Gly Phe Asn His Ser Pro Asn Pro Ser Lys His Gln Arg Asn 
    290                 295                 300                 


Glu Ile Gly Gly Lys Pro Phe Lys Cys Glu Glu Cys Asp Ser Ile Phe 
305                 310                 315                 320 


Lys Trp Phe Ser Asp Leu Thr Lys His Lys Arg Ile His Thr Gly Glu 
                325                 330                 335     


Lys Pro Tyr Lys Cys Asp Glu Cys Gly Lys Ala Tyr Thr Gln Ser Ser 
            340                 345                 350         


His Leu Ser Glu His Arg Arg Ile His Thr Gly Glu Lys Pro Tyr Gln 
        355                 360                 365             


Cys Glu Glu Cys Gly Lys Val Phe Arg Thr Cys Ser Ser Leu Ser Asn 
    370                 375                 380                 


His Lys Arg Thr His Ser Glu Glu Lys Pro Tyr Thr Cys Glu Glu Cys 
385                 390                 395                 400 


Gly Asn Ile Phe Lys Gln Leu Ser Asp Leu Thr Lys His Lys Lys Thr 
                405                 410                 415     


His Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly Lys Asn Phe 
            420                 425                 430         


Thr Gln Ser Ser Asn Leu Ile Val His Lys Arg Ile His Thr Gly Glu 
        435                 440                 445             


Lys Pro Tyr Lys Cys Glu Glu Cys Gly Arg Val Phe Met Trp Phe Ser 
    450                 455                 460                 


Asp Ile Thr Lys His Lys Lys Thr His Thr Gly Glu Lys Pro Tyr Lys 
465                 470                 475                 480 


Cys Asp Glu Cys Gly Lys Asn Phe Thr Gln Ser Ser Asn Leu Ile Val 
                485                 490                 495     


His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Lys Cys 
            500                 505                 510         


Gly Lys Ala Phe Thr Gln Phe Ser His Leu Thr Val His Glu Ser Ile 
        515                 520                 525             


His Thr 
    530 

<210>  2678
<211>  2832
<212>  DNA
<213>  Homo sapiens

<400>  2678
cttttcataa tgattgtagt gcattttctg tgaaatgtta ctgctgtcca ctgcatgcca     60

gtgactcaaa atacctagtt ttcatgacta cacagtcaca gttgaatact gtagttatct    120

aggcaaattc ttttttaatg gtacatcaat gtttcatagc agattttatg actaacatct    180

cttagtgttt tgtaattcca tattactgtt tttatggttg aataatattc cttgtatgta    240

tataccacat tttttctgtg tgttcatcac ttgaggcttc ccccatttga cttttctgaa    300

tagtggtaca gtaaacatgg gtgtgcaaat atctcttcta agtcctgagt tgctttgtat    360

acttttgata tagatctaga aatgggattg ctggatcata taattccatt tttaattttt    420

ttaagaaaat tatgcttttt tttttttttt tacacagagt ttcactctat cacccaggct    480

gtagtgcagt ggtgccatct cagctcactg caacctctgc ttcctgggct cgagccttct    540

tcccacttca gcctcctgag gacctggaac tacaggggca caccgccaca cccagctaac    600

ttttgtgttt ttaatagaga cagggttttg ccatgttgcc caggctggtc tcggactcct    660

gggctcaagt gatccacccg cctcggtctc ccgaagtgct ggggttccag gtgtgagctg    720

gtgtgaacca gtgtgcccgg cctatgctat ctttcatcgt ggctgcatcc tttctttcct    780

accagcaggt tacgtggttt tcaatgtctt cacatccttg acagctatgt cttctcattt    840

tacccaagac cttctgccag agcagggcat acaagatgca ttcccaaaaa gaatactgag    900

aggatatgga aattgtggcc ttgataattt atatttaagg aaagactggg aaagtttaga    960

tgagtgtaag ttgcaaaaag attataatgg acttaaccaa tgttcatcaa ctacccatag   1020

caaaatcttt caatataata aatatgttaa aatctttgat aacttttcaa atttacatag   1080

acgtaatata agtaatactg gagagaaacc tttcaaatgt caagaatgtg gcaaatcctt   1140

tcaaatgctc tcattcctaa ctgaacatca gaaaattcac actggaaaaa aattccaaaa   1200

atgtggagaa tgtggcaaaa cctttatcca gtgctcacac tttactgaac ctgagaacat   1260

tgacactgga gagaaacctt acaagtgtca agaatgtaac aacgtcatta aaacttgctc   1320

agtccttact aaaaatagaa tttatgccgg aggggaacat tacagatgtg aagaatttgg   1380

caaagtattt aaccagtgct cccaccttac tgaacatgag catggtactg aggaaaaacc   1440

ctgcaaatat gaagagtgca gcagtgtctt tatctcttgc tcaagccttt ctaatcaaca   1500

gatgattctt gctggagaga agctctccaa atgtgaaaca tggtacaaag gttttaacca   1560

cagcccaaat ccttccaaac accagagaaa tgagattgga gggaaacctt tcaaatgtga   1620

ggaatgtgac agcatcttca agtggttctc agaccttact aaacataaga gaattcacac   1680

tggtgagaaa ccatacaaat gtgacgaatg tgggaaagcc tatacacagt cctcacacct   1740

cagtgaacac aggaggattc acaccggaga gaaaccctac caatgtgaag aatgtgggaa   1800

ggtcttcaga acttgctcaa gcctttctaa ccataagaga actcattctg aagaaaaacc   1860

ctacacgtgt gaagaatgtg gcaacatctt taagcagtta tcagacctca ctaagcataa   1920

gaaaacccat actggagaga agccctacaa atgtgacgaa tgtggaaaaa actttaccca   1980

gtcctccaac cttattgtac ataagagaat tcatactgga gagaaaccct acaagtgtga   2040

agaatgtggc agagtcttca tgtggttctc agacattacc aaacataaga aaacccatac   2100

tggagagaaa ccctacaaat gtgacgaatg tggaaaaaac tttacccagt cctcaaacct   2160

tattgtacat aagagaattc atactggaga gaaaccctac aagtgtgaaa agtgtggcaa   2220

agccttcacc cagttctcac acctgactgt acatgaaagc attcatactt gagaaaaaaa   2280

taaacaaata taaaaatagg caaagccgtt agtatctgct cgcatcccac tttacatcag   2340

agttcagact taataaagtt atcataaatg taattactat tgaaagacct ttcatgaaat   2400

ataagtctcc agagcacaca agagtatttc ttctgaaaaa aatgttacaa ttatactaga   2460

tggaagactt gcatcagttg cttaaacttt cagaaaattt gtagagaaac ccaacaaatc   2520

tcataaatgt ggaataacat ttgttcaaaa atgatagctt agaaaacact agagttcata   2580

ctaaaagata ttttgcaaat acactaaatg ggaaaaataa gcaaggacac gttcagaaat   2640

gacactgaat ccctgtgttg agtctacaga gacatctaga cttaaaatag atcatttata   2700

tttaagttta aaaggaggat gagactgagt ttttgtagag ttataattac attcaaaata   2760

tacttttttg cattgaaaaa atgttaaatt tttgaaaagc gaatattgat gtcattctat   2820

tctcaaatca gt                                                       2832


<210>  2679
<211>  481
<212>  PRT
<213>  Homo sapiens

<400>  2679


Met Ser Ser His Phe Thr Gln Asp Leu Leu Pro Glu Gln Gly Ile Gln 
1               5                   10                  15      


Asp Ala Phe Pro Lys Arg Ile Leu Arg Gly Tyr Gly Asn Cys Gly Leu 
            20                  25                  30          


Asp Asn Leu Tyr Leu Arg Lys Asp Trp Glu Ser Leu Asp Glu Cys Lys 
        35                  40                  45              


Leu Gln Lys Asp Tyr Asn Gly Leu Asn Gln Cys Ser Ser Thr Thr His 
    50                  55                  60                  


Ser Lys Ile Phe Gln Tyr Asn Lys Tyr Val Lys Ile Phe Asp Asn Phe 
65                  70                  75                  80  


Ser Asn Leu His Arg Arg Asn Ile Ser Asn Thr Gly Glu Lys Pro Phe 
                85                  90                  95      


Lys Cys Gln Glu Cys Gly Lys Ser Phe Gln Met Leu Ser Phe Leu Thr 
            100                 105                 110         


Glu His Gln Lys Ile His Thr Gly Lys Lys Phe Gln Lys Cys Gly Glu 
        115                 120                 125             


Cys Gly Lys Thr Phe Ile Gln Cys Ser His Phe Thr Glu Pro Glu Asn 
    130                 135                 140                 


Ile Asp Thr Gly Glu Lys Pro Tyr Lys Cys Gln Glu Cys Asn Asn Val 
145                 150                 155                 160 


Ile Lys Thr Cys Ser Val Leu Thr Lys Asn Arg Ile Tyr Ala Gly Gly 
                165                 170                 175     


Glu His Tyr Arg Cys Glu Glu Phe Gly Lys Val Phe Asn Gln Cys Ser 
            180                 185                 190         


His Leu Thr Glu His Glu His Gly Thr Glu Glu Lys Pro Cys Lys Tyr 
        195                 200                 205             


Glu Glu Cys Ser Ser Val Phe Ile Ser Cys Ser Ser Leu Ser Asn Gln 
    210                 215                 220                 


Gln Met Ile Leu Ala Gly Glu Lys Leu Ser Lys Cys Glu Thr Trp Tyr 
225                 230                 235                 240 


Lys Gly Phe Asn His Ser Pro Asn Pro Ser Lys His Gln Arg Asn Glu 
                245                 250                 255     


Ile Gly Gly Lys Pro Phe Lys Cys Glu Glu Cys Asp Ser Ile Phe Lys 
            260                 265                 270         


Trp Phe Ser Asp Leu Thr Lys His Lys Arg Ile His Thr Gly Glu Lys 
        275                 280                 285             


Pro Tyr Lys Cys Asp Glu Cys Gly Lys Ala Tyr Thr Gln Ser Ser His 
    290                 295                 300                 


Leu Ser Glu His Arg Arg Ile His Thr Gly Glu Lys Pro Tyr Gln Cys 
305                 310                 315                 320 


Glu Glu Cys Gly Lys Val Phe Arg Thr Cys Ser Ser Leu Ser Asn His 
                325                 330                 335     


Lys Arg Thr His Ser Glu Glu Lys Pro Tyr Thr Cys Glu Glu Cys Gly 
            340                 345                 350         


Asn Ile Phe Lys Gln Leu Ser Asp Leu Thr Lys His Lys Lys Thr His 
        355                 360                 365             


Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly Lys Asn Phe Thr 
    370                 375                 380                 


Gln Ser Ser Asn Leu Ile Val His Lys Arg Ile His Thr Gly Glu Lys 
385                 390                 395                 400 


Pro Tyr Lys Cys Glu Glu Cys Gly Arg Val Phe Met Trp Phe Ser Asp 
                405                 410                 415     


Ile Thr Lys His Lys Lys Thr His Thr Gly Glu Lys Pro Tyr Lys Cys 
            420                 425                 430         


Asp Glu Cys Gly Lys Asn Phe Thr Gln Ser Ser Asn Leu Ile Val His 
        435                 440                 445             


Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Lys Cys Gly 
    450                 455                 460                 


Lys Ala Phe Thr Gln Phe Ser His Leu Thr Val His Glu Ser Ile His 
465                 470                 475                 480 


Thr 
    

<210>  2680
<211>  2328
<212>  DNA
<213>  Homo sapiens

<400>  2680
actctactaa gcacagtaca aggttgataa ttggagaatt tcagcaagag taatgtcact     60

tttttctaat aaaacaggtc tcactgtctg taagccaggc ctgatcacct gcctggagca    120

acgaaaagag ccctggaatg tgaagagaca ggaggcagca gacggacatc cagagatggg    180

atttcaccat gctactcagg cttgtcttga actcctgggc tcaagcgatc tgcctgcctc    240

agcctcccaa agtgctggga ttacaggtgt gaaccaccgt gcccagccag gcctcaatgt    300

ttctgtggac aaattcactg ctatgtcttc tcattttacc caagaccttc tgccagagca    360

gggcatacaa gatgcattcc caaaaagaat actgagagga tatggaaatt gtggccttga    420

taatttatat ttaaggaaag actgggaaag tttagatgag tgtaagttgc aaaaagatta    480

taatggactt aaccaatgtt catcaactac ccatagcaaa atctttcaat ataataaata    540

tgttaaaatc tttgataact tttcaaattt acatagacgt aatataagta atactggaga    600

gaaacctttc aaatgtcaag aatgtggcaa atcctttcaa atgctctcat tcctaactga    660

acatcagaaa attcacactg gaaaaaaatt ccaaaaatgt ggagaatgtg gcaaaacctt    720

tatccagtgc tcacacttta ctgaacctga gaacattgac actggagaga aaccttacaa    780

gtgtcaagaa tgtaacaacg tcattaaaac ttgctcagtc cttactaaaa atagaattta    840

tgccggaggg gaacattaca gatgtgaaga atttggcaaa gtatttaacc agtgctccca    900

ccttactgaa catgagcatg gtactgagga aaaaccctgc aaatatgaag agtgcagcag    960

tgtctttatc tcttgctcaa gcctttctaa tcaacagatg attcttgctg gagagaagct   1020

ctccaaatgt gaaacatggt acaaaggttt taaccacagc ccaaatcctt ccaaacacca   1080

gagaaatgag attggaggga aacctttcaa atgtgaggaa tgtgacagca tcttcaagtg   1140

gttctcagac cttactaaac ataagagaat tcacactggt gagaaaccat acaaatgtga   1200

cgaatgtggg aaagcctata cacagtcctc acacctcagt gaacacagga ggattcacac   1260

cggagagaaa ccctaccaat gtgaagaatg tgggaaggtc ttcagaactt gctcaagcct   1320

ttctaaccat aagagaactc attctgaaga aaaaccctac acgtgtgaag aatgtggcaa   1380

catctttaag cagttatcag acctcactaa gcataagaaa acccatactg gagagaagcc   1440

ctacaaatgt gacgaatgtg gaaaaaactt tacccagtcc tccaacctta ttgtacataa   1500

gagaattcat actggagaga aaccctacaa gtgtgaagaa tgtggcagag tcttcatgtg   1560

gttctcagac attaccaaac ataagaaaac ccatactgga gagaaaccct acaaatgtga   1620

cgaatgtgga aaaaacttta cccagtcctc aaaccttatt gtacataaga gaattcatac   1680

tggagagaaa ccctacaagt gtgaaaagtg tggcaaagcc ttcacccagt tctcacacct   1740

gactgtacat gaaagcattc atacttgaga aaaaaataaa caaatataaa aataggcaaa   1800

gccgttagta tctgctcgca tcccacttta catcagagtt cagacttaat aaagttatca   1860

taaatgtaat tactattgaa agacctttca tgaaatataa gtctccagag cacacaagag   1920

tatttcttct gaaaaaaatg ttacaattat actagatgga agacttgcat cagttgctta   1980

aactttcaga aaatttgtag agaaacccaa caaatctcat aaatgtggaa taacatttgt   2040

tcaaaaatga tagcttagaa aacactagag ttcatactaa aagatatttt gcaaatacac   2100

taaatgggaa aaataagcaa ggacacgttc agaaatgaca ctgaatccct gtgttgagtc   2160

tacagagaca tctagactta aaatagatca tttatattta agtttaaaag gaggatgaga   2220

ctgagttttt gtagagttat aattacattc aaaatatact tttttgcatt gaaaaaatgt   2280

taaatttttg aaaagcgaat attgatgtca ttctattctc aaatcagt                2328


<210>  2681
<211>  571
<212>  PRT
<213>  Homo sapiens

<400>  2681


Met Ser Leu Phe Ser Asn Lys Thr Gly Leu Thr Val Cys Lys Pro Gly 
1               5                   10                  15      


Leu Ile Thr Cys Leu Glu Gln Arg Lys Glu Pro Trp Asn Val Lys Arg 
            20                  25                  30          


Gln Glu Ala Ala Asp Gly His Pro Glu Met Gly Phe His His Ala Thr 
        35                  40                  45              


Gln Ala Cys Leu Glu Leu Leu Gly Ser Ser Asp Leu Pro Ala Ser Ala 
    50                  55                  60                  


Ser Gln Ser Ala Gly Ile Thr Gly Val Asn His Arg Ala Gln Pro Gly 
65                  70                  75                  80  


Leu Asn Val Ser Val Asp Lys Phe Thr Ala Met Ser Ser His Phe Thr 
                85                  90                  95      


Gln Asp Leu Leu Pro Glu Gln Gly Ile Gln Asp Ala Phe Pro Lys Arg 
            100                 105                 110         


Ile Leu Arg Gly Tyr Gly Asn Cys Gly Leu Asp Asn Leu Tyr Leu Arg 
        115                 120                 125             


Lys Asp Trp Glu Ser Leu Asp Glu Cys Lys Leu Gln Lys Asp Tyr Asn 
    130                 135                 140                 


Gly Leu Asn Gln Cys Ser Ser Thr Thr His Ser Lys Ile Phe Gln Tyr 
145                 150                 155                 160 


Asn Lys Tyr Val Lys Ile Phe Asp Asn Phe Ser Asn Leu His Arg Arg 
                165                 170                 175     


Asn Ile Ser Asn Thr Gly Glu Lys Pro Phe Lys Cys Gln Glu Cys Gly 
            180                 185                 190         


Lys Ser Phe Gln Met Leu Ser Phe Leu Thr Glu His Gln Lys Ile His 
        195                 200                 205             


Thr Gly Lys Lys Phe Gln Lys Cys Gly Glu Cys Gly Lys Thr Phe Ile 
    210                 215                 220                 


Gln Cys Ser His Phe Thr Glu Pro Glu Asn Ile Asp Thr Gly Glu Lys 
225                 230                 235                 240 


Pro Tyr Lys Cys Gln Glu Cys Asn Asn Val Ile Lys Thr Cys Ser Val 
                245                 250                 255     


Leu Thr Lys Asn Arg Ile Tyr Ala Gly Gly Glu His Tyr Arg Cys Glu 
            260                 265                 270         


Glu Phe Gly Lys Val Phe Asn Gln Cys Ser His Leu Thr Glu His Glu 
        275                 280                 285             


His Gly Thr Glu Glu Lys Pro Cys Lys Tyr Glu Glu Cys Ser Ser Val 
    290                 295                 300                 


Phe Ile Ser Cys Ser Ser Leu Ser Asn Gln Gln Met Ile Leu Ala Gly 
305                 310                 315                 320 


Glu Lys Leu Ser Lys Cys Glu Thr Trp Tyr Lys Gly Phe Asn His Ser 
                325                 330                 335     


Pro Asn Pro Ser Lys His Gln Arg Asn Glu Ile Gly Gly Lys Pro Phe 
            340                 345                 350         


Lys Cys Glu Glu Cys Asp Ser Ile Phe Lys Trp Phe Ser Asp Leu Thr 
        355                 360                 365             


Lys His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu 
    370                 375                 380                 


Cys Gly Lys Ala Tyr Thr Gln Ser Ser His Leu Ser Glu His Arg Arg 
385                 390                 395                 400 


Ile His Thr Gly Glu Lys Pro Tyr Gln Cys Glu Glu Cys Gly Lys Val 
                405                 410                 415     


Phe Arg Thr Cys Ser Ser Leu Ser Asn His Lys Arg Thr His Ser Glu 
            420                 425                 430         


Glu Lys Pro Tyr Thr Cys Glu Glu Cys Gly Asn Ile Phe Lys Gln Leu 
        435                 440                 445             


Ser Asp Leu Thr Lys His Lys Lys Thr His Thr Gly Glu Lys Pro Tyr 
    450                 455                 460                 


Lys Cys Asp Glu Cys Gly Lys Asn Phe Thr Gln Ser Ser Asn Leu Ile 
465                 470                 475                 480 


Val His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu 
                485                 490                 495     


Cys Gly Arg Val Phe Met Trp Phe Ser Asp Ile Thr Lys His Lys Lys 
            500                 505                 510         


Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly Lys Asn 
        515                 520                 525             


Phe Thr Gln Ser Ser Asn Leu Ile Val His Lys Arg Ile His Thr Gly 
    530                 535                 540                 


Glu Lys Pro Tyr Lys Cys Glu Lys Cys Gly Lys Ala Phe Thr Gln Phe 
545                 550                 555                 560 


Ser His Leu Thr Val His Glu Ser Ile His Thr 
                565                 570     

<210>  2682
<211>  2801
<212>  DNA
<213>  Homo sapiens

<400>  2682
gtgtcccctg ctagccgtag gtcgtgtgac ccgcaggcac cgggagatcc agaagtgaaa     60

cgccaggctc tctggaggcc aggagatgtt tcagtattgt ccagggataa cacaggatgc    120

ccaccatggc catgtctgct ggagcatcta gtgaatttca ggccctgggt tatttctcag    180

aggacagcct gaggtatgaa gtgtggcctc tccagggagc agctggatgc cctgggctga    240

gagaaatctc ctggtctact cttcctctaa agaggtgtga tttgtccaga gaatctttcc    300

taagaggaaa tcccagagaa gcaggagaaa gagaaagaaa tggctggtgc tcagactctg    360

ttgacgttca gggatgtggc catagaattc tccctggagg agtggaaatg cctggacctc    420

gctcagcaga atttgtacag ggatgtgatg ttggagaact acagaaactt gttctccgtt    480

ggtctcactg tctgtaagcc aggcctgatc acctgcctgg agcaacgaaa agagccctgg    540

aatgtgaaga gacaggaggc agcagacgga catccagaga tgggatttca ccatgctact    600

caggcttgtc ttgaactcct gggctcaagc gatctgcctg cctcagcctc ccaaagtgct    660

gggattacag gtgtgaacca ccgtgcccag ccaggcctca atgtttctgt ggacaaattc    720

actgcactgt gctcacctgg ggtgctgcaa actgtgaaat ggtttttaga gttcagatgc    780

atcttctcac tagctatgtc ttctcatttt acccaagacc ttctgccaga gcagggcata    840

caagatgcat tcccaaaaag aatactgaga ggatatggaa attgtggcct tgataattta    900

tatttaagga aagactggga aagtttagat gagtgtaagt tgcaaaaaga ttataatgga    960

cttaaccaat gttcatcaac tacccatagc aaaatctttc aatataataa atatgttaaa   1020

atctttgata acttttcaaa tttacataga cgtaatataa gtaatactgg agagaaacct   1080

ttcaaatgtc aagaatgtgg caaatccttt caaatgctct cattcctaac tgaacatcag   1140

aaaattcaca ctggaaaaaa attccaaaaa tgtggagaat gtggcaaaac ctttatccag   1200

tgctcacact ttactgaacc tgagaacatt gacactggag agaaacctta caagtgtcaa   1260

gaatgtaaca acgtcattaa aacttgctca gtccttacta aaaatagaat ttatgccgga   1320

ggggaacatt acagatgtga agaatttggc aaagtattta accagtgctc ccaccttact   1380

gaacatgagc atggtactga ggaaaaaccc tgcaaatatg aagagtgcag cagtgtcttt   1440

atctcttgct caagcctttc taatcaacag atgattcttg ctggagagaa gctctccaaa   1500

tgtgaaacat ggtacaaagg ttttaaccac agcccaaatc cttccaaaca ccagagaaat   1560

gagattggag ggaaaccttt caaatgtgag gaatgtgaca gcatcttcaa gtggttctca   1620

gaccttacta aacataagag aattcacact ggtgagaaac catacaaatg tgacgaatgt   1680

gggaaagcct atacacagtc ctcacacctc agtgaacaca ggaggattca caccggagag   1740

aaaccctacc aatgtgaaga atgtgggaag gtcttcagaa cttgctcaag cctttctaac   1800

cataagagaa ctcattctga agaaaaaccc tacacgtgtg aagaatgtgg caacatcttt   1860

aagcagttat cagacctcac taagcataag aaaacccata ctggagagaa gccctacaaa   1920

tgtgacgaat gtggaaaaaa ctttacccag tcctccaacc ttattgtaca taagagaatt   1980

catactggag agaaacccta caagtgtgaa gaatgtggca gagtcttcat gtggttctca   2040

gacattacca aacataagaa aacccatact ggagagaaac cctacaaatg tgacgaatgt   2100

ggaaaaaact ttacccagtc ctcaaacctt attgtacata agagaattca tactggagag   2160

aaaccctaca agtgtgaaaa gtgtggcaaa gccttcaccc agttctcaca cctgactgta   2220

catgaaagca ttcatacttg agaaaaaaat aaacaaatat aaaaataggc aaagccgtta   2280

gtatctgctc gcatcccact ttacatcaga gttcagactt aataaagtta tcataaatgt   2340

aattactatt gaaagacctt tcatgaaata taagtctcca gagcacacaa gagtatttct   2400

tctgaaaaaa atgttacaat tatactagat ggaagacttg catcagttgc ttaaactttc   2460

agaaaatttg tagagaaacc caacaaatct cataaatgtg gaataacatt tgttcaaaaa   2520

tgatagctta gaaaacacta gagttcatac taaaagatat tttgcaaata cactaaatgg   2580

gaaaaataag caaggacacg ttcagaaatg acactgaatc cctgtgttga gtctacagag   2640

acatctagac ttaaaataga tcatttatat ttaagtttaa aaggaggatg agactgagtt   2700

tttgtagagt tataattaca ttcaaaatat acttttttgc attgaaaaaa tgttaaattt   2760

ttgaaaagcg aatattgatg tcattctatt ctcaaatcag t                       2801


<210>  2683
<211>  633
<212>  PRT
<213>  Homo sapiens

<400>  2683


Met Ala Gly Ala Gln Thr Leu Leu Thr Phe Arg Asp Val Ala Ile Glu 
1               5                   10                  15      


Phe Ser Leu Glu Glu Trp Lys Cys Leu Asp Leu Ala Gln Gln Asn Leu 
            20                  25                  30          


Tyr Arg Asp Val Met Leu Glu Asn Tyr Arg Asn Leu Phe Ser Val Gly 
        35                  40                  45              


Leu Thr Val Cys Lys Pro Gly Leu Ile Thr Cys Leu Glu Gln Arg Lys 
    50                  55                  60                  


Glu Pro Trp Asn Val Lys Arg Gln Glu Ala Ala Asp Gly His Pro Glu 
65                  70                  75                  80  


Met Gly Phe His His Ala Thr Gln Ala Cys Leu Glu Leu Leu Gly Ser 
                85                  90                  95      


Ser Asp Leu Pro Ala Ser Ala Ser Gln Ser Ala Gly Ile Thr Gly Val 
            100                 105                 110         


Asn His Arg Ala Gln Pro Gly Leu Asn Val Ser Val Asp Lys Phe Thr 
        115                 120                 125             


Ala Leu Cys Ser Pro Gly Val Leu Gln Thr Val Lys Trp Phe Leu Glu 
    130                 135                 140                 


Phe Arg Cys Ile Phe Ser Leu Ala Met Ser Ser His Phe Thr Gln Asp 
145                 150                 155                 160 


Leu Leu Pro Glu Gln Gly Ile Gln Asp Ala Phe Pro Lys Arg Ile Leu 
                165                 170                 175     


Arg Gly Tyr Gly Asn Cys Gly Leu Asp Asn Leu Tyr Leu Arg Lys Asp 
            180                 185                 190         


Trp Glu Ser Leu Asp Glu Cys Lys Leu Gln Lys Asp Tyr Asn Gly Leu 
        195                 200                 205             


Asn Gln Cys Ser Ser Thr Thr His Ser Lys Ile Phe Gln Tyr Asn Lys 
    210                 215                 220                 


Tyr Val Lys Ile Phe Asp Asn Phe Ser Asn Leu His Arg Arg Asn Ile 
225                 230                 235                 240 


Ser Asn Thr Gly Glu Lys Pro Phe Lys Cys Gln Glu Cys Gly Lys Ser 
                245                 250                 255     


Phe Gln Met Leu Ser Phe Leu Thr Glu His Gln Lys Ile His Thr Gly 
            260                 265                 270         


Lys Lys Phe Gln Lys Cys Gly Glu Cys Gly Lys Thr Phe Ile Gln Cys 
        275                 280                 285             


Ser His Phe Thr Glu Pro Glu Asn Ile Asp Thr Gly Glu Lys Pro Tyr 
    290                 295                 300                 


Lys Cys Gln Glu Cys Asn Asn Val Ile Lys Thr Cys Ser Val Leu Thr 
305                 310                 315                 320 


Lys Asn Arg Ile Tyr Ala Gly Gly Glu His Tyr Arg Cys Glu Glu Phe 
                325                 330                 335     


Gly Lys Val Phe Asn Gln Cys Ser His Leu Thr Glu His Glu His Gly 
            340                 345                 350         


Thr Glu Glu Lys Pro Cys Lys Tyr Glu Glu Cys Ser Ser Val Phe Ile 
        355                 360                 365             


Ser Cys Ser Ser Leu Ser Asn Gln Gln Met Ile Leu Ala Gly Glu Lys 
    370                 375                 380                 


Leu Ser Lys Cys Glu Thr Trp Tyr Lys Gly Phe Asn His Ser Pro Asn 
385                 390                 395                 400 


Pro Ser Lys His Gln Arg Asn Glu Ile Gly Gly Lys Pro Phe Lys Cys 
                405                 410                 415     


Glu Glu Cys Asp Ser Ile Phe Lys Trp Phe Ser Asp Leu Thr Lys His 
            420                 425                 430         


Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly 
        435                 440                 445             


Lys Ala Tyr Thr Gln Ser Ser His Leu Ser Glu His Arg Arg Ile His 
    450                 455                 460                 


Thr Gly Glu Lys Pro Tyr Gln Cys Glu Glu Cys Gly Lys Val Phe Arg 
465                 470                 475                 480 


Thr Cys Ser Ser Leu Ser Asn His Lys Arg Thr His Ser Glu Glu Lys 
                485                 490                 495     


Pro Tyr Thr Cys Glu Glu Cys Gly Asn Ile Phe Lys Gln Leu Ser Asp 
            500                 505                 510         


Leu Thr Lys His Lys Lys Thr His Thr Gly Glu Lys Pro Tyr Lys Cys 
        515                 520                 525             


Asp Glu Cys Gly Lys Asn Phe Thr Gln Ser Ser Asn Leu Ile Val His 
    530                 535                 540                 


Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly 
545                 550                 555                 560 


Arg Val Phe Met Trp Phe Ser Asp Ile Thr Lys His Lys Lys Thr His 
                565                 570                 575     


Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly Lys Asn Phe Thr 
            580                 585                 590         


Gln Ser Ser Asn Leu Ile Val His Lys Arg Ile His Thr Gly Glu Lys 
        595                 600                 605             


Pro Tyr Lys Cys Glu Lys Cys Gly Lys Ala Phe Thr Gln Phe Ser His 
    610                 615                 620                 


Leu Thr Val His Glu Ser Ile His Thr 
625                 630             

<210>  2684
<211>  2835
<212>  DNA
<213>  Homo sapiens

<400>  2684
ctgtccccgc ggctctgtgt cccctgctag ccgtaggtcg tgtgacccgc aggcaccggg     60

agatccagaa gtgaaacgcc aggctctctg gaggccagga gatggcacag acaccttacc    120

agaatgtctt tggtttgagg ttccactttg gaaacttgac agggtgattt gctctcagcc    180

accctctgga ctttttcctc agtttcagta ttgtccaggg ataacacagg atgcccacca    240

tggccatgtc tgctggagca tctagtgaat ttcaggccct gggttatttc tcagaggaca    300

gcctgaggta tgaagtgtgg cctctccagg gagcagctgg atgccctggg ctgagagaaa    360

tctcctggtc tactcttcct ctaaagagac tctgttgacg ttcagggatg tggccataga    420

attctccctg gaggagtgga aatgcctgga cctcgctcag cagaatttgt acagggatgt    480

gatgttggag aactacagaa acttgttctc cgttggtctc actgtctgta agccaggcct    540

gatcacctgc ctggagcaac gaaaagagcc ctggaatgtg aagagacagg aggcagcaga    600

cggacatcca gagatgggat ttcaccatgc tactcaggct tgtcttgaac tcctgggctc    660

aagcgatctg cctgcctcag cctcccaaag tgctgggatt acaggtgtga accaccgtgc    720

ccagccaggc ctcaatgttt ctgtggacaa attcactgca ctgtgctcac ctggggtgct    780

gcaaactgtg aaatggtttt tagagttcag atgcatcttc tcactagcta tgtcttctca    840

ttttacccaa gaccttctgc cagagcaggg catacaagat gcattcccaa aaagaatact    900

gagaggatat ggaaattgtg gccttgataa tttatattta aggaaagact gggaaagttt    960

agatgagtgt aagttgcaaa aagattataa tggacttaac caatgttcat caactaccca   1020

tagcaaaatc tttcaatata ataaatatgt taaaatcttt gataactttt caaatttaca   1080

tagacgtaat ataagtaata ctggagagaa acctttcaaa tgtcaagaat gtggcaaatc   1140

ctttcaaatg ctctcattcc taactgaaca tcagaaaatt cacactggaa aaaaattcca   1200

aaaatgtgga gaatgtggca aaacctttat ccagtgctca cactttactg aacctgagaa   1260

cattgacact ggagagaaac cttacaagtg tcaagaatgt aacaacgtca ttaaaacttg   1320

ctcagtcctt actaaaaata gaatttatgc cggaggggaa cattacagat gtgaagaatt   1380

tggcaaagta tttaaccagt gctcccacct tactgaacat gagcatggta ctgaggaaaa   1440

accctgcaaa tatgaagagt gcagcagtgt ctttatctct tgctcaagcc tttctaatca   1500

acagatgatt cttgctggag agaagctctc caaatgtgaa acatggtaca aaggttttaa   1560

ccacagccca aatccttcca aacaccagag aaatgagatt ggagggaaac ctttcaaatg   1620

tgaggaatgt gacagcatct tcaagtggtt ctcagacctt actaaacata agagaattca   1680

cactggtgag aaaccataca aatgtgacga atgtgggaaa gcctatacac agtcctcaca   1740

cctcagtgaa cacaggagga ttcacaccgg agagaaaccc taccaatgtg aagaatgtgg   1800

gaaggtcttc agaacttgct caagcctttc taaccataag agaactcatt ctgaagaaaa   1860

accctacacg tgtgaagaat gtggcaacat ctttaagcag ttatcagacc tcactaagca   1920

taagaaaacc catactggag agaagcccta caaatgtgac gaatgtggaa aaaactttac   1980

ccagtcctcc aaccttattg tacataagag aattcatact ggagagaaac cctacaagtg   2040

tgaagaatgt ggcagagtct tcatgtggtt ctcagacatt accaaacata agaaaaccca   2100

tactggagag aaaccctaca aatgtgacga atgtggaaaa aactttaccc agtcctcaaa   2160

ccttattgta cataagagaa ttcatactgg agagaaaccc tacaagtgtg aaaagtgtgg   2220

caaagccttc acccagttct cacacctgac tgtacatgaa agcattcata cttgagaaaa   2280

aaataaacaa atataaaaat aggcaaagcc gttagtatct gctcgcatcc cactttacat   2340

cagagttcag acttaataaa gttatcataa atgtaattac tattgaaaga cctttcatga   2400

aatataagtc tccagagcac acaagagtat ttcttctgaa aaaaatgtta caattatact   2460

agatggaaga cttgcatcag ttgcttaaac tttcagaaaa tttgtagaga aacccaacaa   2520

atctcataaa tgtggaataa catttgttca aaaatgatag cttagaaaac actagagttc   2580

atactaaaag atattttgca aatacactaa atgggaaaaa taagcaagga cacgttcaga   2640

aatgacactg aatccctgtg ttgagtctac agagacatct agacttaaaa tagatcattt   2700

atatttaagt ttaaaaggag gatgagactg agtttttgta gagttataat tacattcaaa   2760

atatactttt ttgcattgaa aaaatgttaa atttttgaaa agcgaatatt gatgtcattc   2820

tattctcaaa tcagt                                                    2835


<210>  2685
<211>  644
<212>  PRT
<213>  Homo sapiens

<400>  2685


Met Pro Trp Ala Glu Arg Asn Leu Leu Val Tyr Ser Ser Ser Lys Glu 
1               5                   10                  15      


Thr Leu Leu Thr Phe Arg Asp Val Ala Ile Glu Phe Ser Leu Glu Glu 
            20                  25                  30          


Trp Lys Cys Leu Asp Leu Ala Gln Gln Asn Leu Tyr Arg Asp Val Met 
        35                  40                  45              


Leu Glu Asn Tyr Arg Asn Leu Phe Ser Val Gly Leu Thr Val Cys Lys 
    50                  55                  60                  


Pro Gly Leu Ile Thr Cys Leu Glu Gln Arg Lys Glu Pro Trp Asn Val 
65                  70                  75                  80  


Lys Arg Gln Glu Ala Ala Asp Gly His Pro Glu Met Gly Phe His His 
                85                  90                  95      


Ala Thr Gln Ala Cys Leu Glu Leu Leu Gly Ser Ser Asp Leu Pro Ala 
            100                 105                 110         


Ser Ala Ser Gln Ser Ala Gly Ile Thr Gly Val Asn His Arg Ala Gln 
        115                 120                 125             


Pro Gly Leu Asn Val Ser Val Asp Lys Phe Thr Ala Leu Cys Ser Pro 
    130                 135                 140                 


Gly Val Leu Gln Thr Val Lys Trp Phe Leu Glu Phe Arg Cys Ile Phe 
145                 150                 155                 160 


Ser Leu Ala Met Ser Ser His Phe Thr Gln Asp Leu Leu Pro Glu Gln 
                165                 170                 175     


Gly Ile Gln Asp Ala Phe Pro Lys Arg Ile Leu Arg Gly Tyr Gly Asn 
            180                 185                 190         


Cys Gly Leu Asp Asn Leu Tyr Leu Arg Lys Asp Trp Glu Ser Leu Asp 
        195                 200                 205             


Glu Cys Lys Leu Gln Lys Asp Tyr Asn Gly Leu Asn Gln Cys Ser Ser 
    210                 215                 220                 


Thr Thr His Ser Lys Ile Phe Gln Tyr Asn Lys Tyr Val Lys Ile Phe 
225                 230                 235                 240 


Asp Asn Phe Ser Asn Leu His Arg Arg Asn Ile Ser Asn Thr Gly Glu 
                245                 250                 255     


Lys Pro Phe Lys Cys Gln Glu Cys Gly Lys Ser Phe Gln Met Leu Ser 
            260                 265                 270         


Phe Leu Thr Glu His Gln Lys Ile His Thr Gly Lys Lys Phe Gln Lys 
        275                 280                 285             


Cys Gly Glu Cys Gly Lys Thr Phe Ile Gln Cys Ser His Phe Thr Glu 
    290                 295                 300                 


Pro Glu Asn Ile Asp Thr Gly Glu Lys Pro Tyr Lys Cys Gln Glu Cys 
305                 310                 315                 320 


Asn Asn Val Ile Lys Thr Cys Ser Val Leu Thr Lys Asn Arg Ile Tyr 
                325                 330                 335     


Ala Gly Gly Glu His Tyr Arg Cys Glu Glu Phe Gly Lys Val Phe Asn 
            340                 345                 350         


Gln Cys Ser His Leu Thr Glu His Glu His Gly Thr Glu Glu Lys Pro 
        355                 360                 365             


Cys Lys Tyr Glu Glu Cys Ser Ser Val Phe Ile Ser Cys Ser Ser Leu 
    370                 375                 380                 


Ser Asn Gln Gln Met Ile Leu Ala Gly Glu Lys Leu Ser Lys Cys Glu 
385                 390                 395                 400 


Thr Trp Tyr Lys Gly Phe Asn His Ser Pro Asn Pro Ser Lys His Gln 
                405                 410                 415     


Arg Asn Glu Ile Gly Gly Lys Pro Phe Lys Cys Glu Glu Cys Asp Ser 
            420                 425                 430         


Ile Phe Lys Trp Phe Ser Asp Leu Thr Lys His Lys Arg Ile His Thr 
        435                 440                 445             


Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly Lys Ala Tyr Thr Gln 
    450                 455                 460                 


Ser Ser His Leu Ser Glu His Arg Arg Ile His Thr Gly Glu Lys Pro 
465                 470                 475                 480 


Tyr Gln Cys Glu Glu Cys Gly Lys Val Phe Arg Thr Cys Ser Ser Leu 
                485                 490                 495     


Ser Asn His Lys Arg Thr His Ser Glu Glu Lys Pro Tyr Thr Cys Glu 
            500                 505                 510         


Glu Cys Gly Asn Ile Phe Lys Gln Leu Ser Asp Leu Thr Lys His Lys 
        515                 520                 525             


Lys Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly Lys 
    530                 535                 540                 


Asn Phe Thr Gln Ser Ser Asn Leu Ile Val His Lys Arg Ile His Thr 
545                 550                 555                 560 


Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Arg Val Phe Met Trp 
                565                 570                 575     


Phe Ser Asp Ile Thr Lys His Lys Lys Thr His Thr Gly Glu Lys Pro 
            580                 585                 590         


Tyr Lys Cys Asp Glu Cys Gly Lys Asn Phe Thr Gln Ser Ser Asn Leu 
        595                 600                 605             


Ile Val His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu 
    610                 615                 620                 


Lys Cys Gly Lys Ala Phe Thr Gln Phe Ser His Leu Thr Val His Glu 
625                 630                 635                 640 


Ser Ile His Thr 
                

<210>  2686
<211>  2810
<212>  DNA
<213>  Homo sapiens

<400>  2686
agagctccac ttcctgtccc cgcggctctg tgtcccctgc tagccgtagg tcgtgtgacc     60

cgcaggcacc gggagatcca gaagtgaaac gccaggctct ctggaggcca ggagatgcca    120

ttaggaaaac agagaaggca gccatggtcc ccgcaagcca gaaacttttc catttccagt    180

aactggataa atcattgaat tcagcgtctt ggggtcagca tgaagaaggg agtggtcaaa    240

gggacttctg cttcatttgg gccattttcc tgatgtggtt gttgtgtgat ttgtccagag    300

aatctttcct aagaggaaat cccagagaag caggagaaag agaaagaaat ggctggtgct    360

cagactctgt tgacgttcag ggatgtggcc atagaattct ccctggagga gtggaaatgc    420

ctggacctcg ctcagcagaa tttgtacagg gatgtgatgt tggagaacta cagaaacttg    480

ttctccgttg gtctcactgt ctgtaagcca ggcctgatca cctgcctgga gcaacgaaaa    540

gagccctgga atgtgaagag acaggaggca gcagacggac atccagagat gggatttcac    600

catgctactc aggcttgtct tgaactcctg ggctcaagcg atctgcctgc ctcagcctcc    660

caaagtgctg ggattacagg tgtgaaccac cgtgcccagc caggcctcaa tgtttctgtg    720

gacaaattca ctgcactgtg ctcacctggg gtgctgcaaa ctgtgaaatg gtttttagag    780

ttcagatgca tcttctcact agctatgtct tctcatttta cccaagacct tctgccagag    840

cagggcatac aagatgcatt cccaaaaaga atactgagag gatatggaaa ttgtggcctt    900

gataatttat atttaaggaa agactgggaa agtttagatg agtgtaagtt gcaaaaagat    960

tataatggac ttaaccaatg ttcatcaact acccatagca aaatctttca atataataaa   1020

tatgttaaaa tctttgataa cttttcaaat ttacatagac gtaatataag taatactgga   1080

gagaaacctt tcaaatgtca agaatgtggc aaatcctttc aaatgctctc attcctaact   1140

gaacatcaga aaattcacac tggaaaaaaa ttccaaaaat gtggagaatg tggcaaaacc   1200

tttatccagt gctcacactt tactgaacct gagaacattg acactggaga gaaaccttac   1260

aagtgtcaag aatgtaacaa cgtcattaaa acttgctcag tccttactaa aaatagaatt   1320

tatgccggag gggaacatta cagatgtgaa gaatttggca aagtatttaa ccagtgctcc   1380

caccttactg aacatgagca tggtactgag gaaaaaccct gcaaatatga agagtgcagc   1440

agtgtcttta tctcttgctc aagcctttct aatcaacaga tgattcttgc tggagagaag   1500

ctctccaaat gtgaaacatg gtacaaaggt tttaaccaca gcccaaatcc ttccaaacac   1560

cagagaaatg agattggagg gaaacctttc aaatgtgagg aatgtgacag catcttcaag   1620

tggttctcag accttactaa acataagaga attcacactg gtgagaaacc atacaaatgt   1680

gacgaatgtg ggaaagccta tacacagtcc tcacacctca gtgaacacag gaggattcac   1740

accggagaga aaccctacca atgtgaagaa tgtgggaagg tcttcagaac ttgctcaagc   1800

ctttctaacc ataagagaac tcattctgaa gaaaaaccct acacgtgtga agaatgtggc   1860

aacatcttta agcagttatc agacctcact aagcataaga aaacccatac tggagagaag   1920

ccctacaaat gtgacgaatg tggaaaaaac tttacccagt cctccaacct tattgtacat   1980

aagagaattc atactggaga gaaaccctac aagtgtgaag aatgtggcag agtcttcatg   2040

tggttctcag acattaccaa acataagaaa acccatactg gagagaaacc ctacaaatgt   2100

gacgaatgtg gaaaaaactt tacccagtcc tcaaacctta ttgtacataa gagaattcat   2160

actggagaga aaccctacaa gtgtgaaaag tgtggcaaag ccttcaccca gttctcacac   2220

ctgactgtac atgaaagcat tcatacttga gaaaaaaata aacaaatata aaaataggca   2280

aagccgttag tatctgctcg catcccactt tacatcagag ttcagactta ataaagttat   2340

cataaatgta attactattg aaagaccttt catgaaatat aagtctccag agcacacaag   2400

agtatttctt ctgaaaaaaa tgttacaatt atactagatg gaagacttgc atcagttgct   2460

taaactttca gaaaatttgt agagaaaccc aacaaatctc ataaatgtgg aataacattt   2520

gttcaaaaat gatagcttag aaaacactag agttcatact aaaagatatt ttgcaaatac   2580

actaaatggg aaaaataagc aaggacacgt tcagaaatga cactgaatcc ctgtgttgag   2640

tctacagaga catctagact taaaatagat catttatatt taagtttaaa aggaggatga   2700

gactgagttt ttgtagagtt ataattacat tcaaaatata cttttttgca ttgaaaaaat   2760

gttaaatttt tgaaaagcga atattgatgt cattctattc tcaaatcagt              2810


<210>  2687
<211>  633
<212>  PRT
<213>  Homo sapiens

<400>  2687


Met Ala Gly Ala Gln Thr Leu Leu Thr Phe Arg Asp Val Ala Ile Glu 
1               5                   10                  15      


Phe Ser Leu Glu Glu Trp Lys Cys Leu Asp Leu Ala Gln Gln Asn Leu 
            20                  25                  30          


Tyr Arg Asp Val Met Leu Glu Asn Tyr Arg Asn Leu Phe Ser Val Gly 
        35                  40                  45              


Leu Thr Val Cys Lys Pro Gly Leu Ile Thr Cys Leu Glu Gln Arg Lys 
    50                  55                  60                  


Glu Pro Trp Asn Val Lys Arg Gln Glu Ala Ala Asp Gly His Pro Glu 
65                  70                  75                  80  


Met Gly Phe His His Ala Thr Gln Ala Cys Leu Glu Leu Leu Gly Ser 
                85                  90                  95      


Ser Asp Leu Pro Ala Ser Ala Ser Gln Ser Ala Gly Ile Thr Gly Val 
            100                 105                 110         


Asn His Arg Ala Gln Pro Gly Leu Asn Val Ser Val Asp Lys Phe Thr 
        115                 120                 125             


Ala Leu Cys Ser Pro Gly Val Leu Gln Thr Val Lys Trp Phe Leu Glu 
    130                 135                 140                 


Phe Arg Cys Ile Phe Ser Leu Ala Met Ser Ser His Phe Thr Gln Asp 
145                 150                 155                 160 


Leu Leu Pro Glu Gln Gly Ile Gln Asp Ala Phe Pro Lys Arg Ile Leu 
                165                 170                 175     


Arg Gly Tyr Gly Asn Cys Gly Leu Asp Asn Leu Tyr Leu Arg Lys Asp 
            180                 185                 190         


Trp Glu Ser Leu Asp Glu Cys Lys Leu Gln Lys Asp Tyr Asn Gly Leu 
        195                 200                 205             


Asn Gln Cys Ser Ser Thr Thr His Ser Lys Ile Phe Gln Tyr Asn Lys 
    210                 215                 220                 


Tyr Val Lys Ile Phe Asp Asn Phe Ser Asn Leu His Arg Arg Asn Ile 
225                 230                 235                 240 


Ser Asn Thr Gly Glu Lys Pro Phe Lys Cys Gln Glu Cys Gly Lys Ser 
                245                 250                 255     


Phe Gln Met Leu Ser Phe Leu Thr Glu His Gln Lys Ile His Thr Gly 
            260                 265                 270         


Lys Lys Phe Gln Lys Cys Gly Glu Cys Gly Lys Thr Phe Ile Gln Cys 
        275                 280                 285             


Ser His Phe Thr Glu Pro Glu Asn Ile Asp Thr Gly Glu Lys Pro Tyr 
    290                 295                 300                 


Lys Cys Gln Glu Cys Asn Asn Val Ile Lys Thr Cys Ser Val Leu Thr 
305                 310                 315                 320 


Lys Asn Arg Ile Tyr Ala Gly Gly Glu His Tyr Arg Cys Glu Glu Phe 
                325                 330                 335     


Gly Lys Val Phe Asn Gln Cys Ser His Leu Thr Glu His Glu His Gly 
            340                 345                 350         


Thr Glu Glu Lys Pro Cys Lys Tyr Glu Glu Cys Ser Ser Val Phe Ile 
        355                 360                 365             


Ser Cys Ser Ser Leu Ser Asn Gln Gln Met Ile Leu Ala Gly Glu Lys 
    370                 375                 380                 


Leu Ser Lys Cys Glu Thr Trp Tyr Lys Gly Phe Asn His Ser Pro Asn 
385                 390                 395                 400 


Pro Ser Lys His Gln Arg Asn Glu Ile Gly Gly Lys Pro Phe Lys Cys 
                405                 410                 415     


Glu Glu Cys Asp Ser Ile Phe Lys Trp Phe Ser Asp Leu Thr Lys His 
            420                 425                 430         


Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly 
        435                 440                 445             


Lys Ala Tyr Thr Gln Ser Ser His Leu Ser Glu His Arg Arg Ile His 
    450                 455                 460                 


Thr Gly Glu Lys Pro Tyr Gln Cys Glu Glu Cys Gly Lys Val Phe Arg 
465                 470                 475                 480 


Thr Cys Ser Ser Leu Ser Asn His Lys Arg Thr His Ser Glu Glu Lys 
                485                 490                 495     


Pro Tyr Thr Cys Glu Glu Cys Gly Asn Ile Phe Lys Gln Leu Ser Asp 
            500                 505                 510         


Leu Thr Lys His Lys Lys Thr His Thr Gly Glu Lys Pro Tyr Lys Cys 
        515                 520                 525             


Asp Glu Cys Gly Lys Asn Phe Thr Gln Ser Ser Asn Leu Ile Val His 
    530                 535                 540                 


Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly 
545                 550                 555                 560 


Arg Val Phe Met Trp Phe Ser Asp Ile Thr Lys His Lys Lys Thr His 
                565                 570                 575     


Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly Lys Asn Phe Thr 
            580                 585                 590         


Gln Ser Ser Asn Leu Ile Val His Lys Arg Ile His Thr Gly Glu Lys 
        595                 600                 605             


Pro Tyr Lys Cys Glu Lys Cys Gly Lys Ala Phe Thr Gln Phe Ser His 
    610                 615                 620                 


Leu Thr Val His Glu Ser Ile His Thr 
625                 630             

<210>  2688
<211>  2573
<212>  DNA
<213>  Homo sapiens

<400>  2688
gtcccgacag agctccactt cctgtccccg cggctctgtg tcccctgcta gccgtaggtc     60

gtgtgacccg caggcaccgg gagatccaga agtgaaacgc caggctctct ggaggccagg    120

agatgactct gttgacgttc agggatgtgg ccatagaatt ctccctggag gagtggaaat    180

gcctggacct cgctcagcag aatttgtaca gggatgtgat gttggagaac tacagaaact    240

tgttctccgt tggtctcact gtctgtaagc caggcctgat cacctgcctg gagcaacgaa    300

aagagccctg gaatgtgaag agacaggagg cagcagacgg acatccaggt attttctttg    360

tggttaccat ggaaattata taaaacatct taaagttaca acaaggtatt ttacactgag    420

atgggatttc accatgctac tcaggcttgt cttgaactcc tgggctcaag cgatctgcct    480

gcctcagcct cccaaagtgc tgggattaca ggtgtgaacc accgtgccca gccaggcctc    540

aatgtttctg tggacaaatt cactgctatg tcttctcatt ttacccaaga ccttctgcca    600

gagcagggca tacaagatgc attcccaaaa agaatactga gaggatatgg aaattgtggc    660

cttgataatt tatatttaag gaaagactgg gaaagtttag atgagtgtaa gttgcaaaaa    720

gattataatg gacttaacca atgttcatca actacccata gcaaaatctt tcaatataat    780

aaatatgtta aaatctttga taacttttca aatttacata gacgtaatat aagtaatact    840

ggagagaaac ctttcaaatg tcaagaatgt ggcaaatcct ttcaaatgct ctcattccta    900

actgaacatc agaaaattca cactggaaaa aaattccaaa aatgtggaga atgtggcaaa    960

acctttatcc agtgctcaca ctttactgaa cctgagaaca ttgacactgg agagaaacct   1020

tacaagtgtc aagaatgtaa caacgtcatt aaaacttgct cagtccttac taaaaataga   1080

atttatgccg gaggggaaca ttacagatgt gaagaatttg gcaaagtatt taaccagtgc   1140

tcccacctta ctgaacatga gcatggtact gaggaaaaac cctgcaaata tgaagagtgc   1200

agcagtgtct ttatctcttg ctcaagcctt tctaatcaac agatgattct tgctggagag   1260

aagctctcca aatgtgaaac atggtacaaa ggttttaacc acagcccaaa tccttccaaa   1320

caccagagaa atgagattgg agggaaacct ttcaaatgtg aggaatgtga cagcatcttc   1380

aagtggttct cagaccttac taaacataag agaattcaca ctggtgagaa accatacaaa   1440

tgtgacgaat gtgggaaagc ctatacacag tcctcacacc tcagtgaaca caggaggatt   1500

cacaccggag agaaacccta ccaatgtgaa gaatgtggga aggtcttcag aacttgctca   1560

agcctttcta accataagag aactcattct gaagaaaaac cctacacgtg tgaagaatgt   1620

ggcaacatct ttaagcagtt atcagacctc actaagcata agaaaaccca tactggagag   1680

aagccctaca aatgtgacga atgtggaaaa aactttaccc agtcctccaa ccttattgta   1740

cataagagaa ttcatactgg agagaaaccc tacaagtgtg aagaatgtgg cagagtcttc   1800

atgtggttct cagacattac caaacataag aaaacccata ctggagagaa accctacaaa   1860

tgtgacgaat gtggaaaaaa ctttacccag tcctcaaacc ttattgtaca taagagaatt   1920

catactggag agaaacccta caagtgtgaa aagtgtggca aagccttcac ccagttctca   1980

cacctgactg tacatgaaag cattcatact tgagaaaaaa ataaacaaat ataaaaatag   2040

gcaaagccgt tagtatctgc tcgcatccca ctttacatca gagttcagac ttaataaagt   2100

tatcataaat gtaattacta ttgaaagacc tttcatgaaa tataagtctc cagagcacac   2160

aagagtattt cttctgaaaa aaatgttaca attatactag atggaagact tgcatcagtt   2220

gcttaaactt tcagaaaatt tgtagagaaa cccaacaaat ctcataaatg tggaataaca   2280

tttgttcaaa aatgatagct tagaaaacac tagagttcat actaaaagat attttgcaaa   2340

tacactaaat gggaaaaata agcaaggaca cgttcagaaa tgacactgaa tccctgtgtt   2400

gagtctacag agacatctag acttaaaata gatcatttat atttaagttt aaaaggagga   2460

tgagactgag tttttgtaga gttataatta cattcaaaat atactttttt gcattgaaaa   2520

aatgttaaat ttttgaaaag cgaatattga tgtcattcta ttctcaaatc agt          2573


<210>  2689
<211>  530
<212>  PRT
<213>  Homo sapiens

<400>  2689


Met Gly Phe His His Ala Thr Gln Ala Cys Leu Glu Leu Leu Gly Ser 
1               5                   10                  15      


Ser Asp Leu Pro Ala Ser Ala Ser Gln Ser Ala Gly Ile Thr Gly Val 
            20                  25                  30          


Asn His Arg Ala Gln Pro Gly Leu Asn Val Ser Val Asp Lys Phe Thr 
        35                  40                  45              


Ala Met Ser Ser His Phe Thr Gln Asp Leu Leu Pro Glu Gln Gly Ile 
    50                  55                  60                  


Gln Asp Ala Phe Pro Lys Arg Ile Leu Arg Gly Tyr Gly Asn Cys Gly 
65                  70                  75                  80  


Leu Asp Asn Leu Tyr Leu Arg Lys Asp Trp Glu Ser Leu Asp Glu Cys 
                85                  90                  95      


Lys Leu Gln Lys Asp Tyr Asn Gly Leu Asn Gln Cys Ser Ser Thr Thr 
            100                 105                 110         


His Ser Lys Ile Phe Gln Tyr Asn Lys Tyr Val Lys Ile Phe Asp Asn 
        115                 120                 125             


Phe Ser Asn Leu His Arg Arg Asn Ile Ser Asn Thr Gly Glu Lys Pro 
    130                 135                 140                 


Phe Lys Cys Gln Glu Cys Gly Lys Ser Phe Gln Met Leu Ser Phe Leu 
145                 150                 155                 160 


Thr Glu His Gln Lys Ile His Thr Gly Lys Lys Phe Gln Lys Cys Gly 
                165                 170                 175     


Glu Cys Gly Lys Thr Phe Ile Gln Cys Ser His Phe Thr Glu Pro Glu 
            180                 185                 190         


Asn Ile Asp Thr Gly Glu Lys Pro Tyr Lys Cys Gln Glu Cys Asn Asn 
        195                 200                 205             


Val Ile Lys Thr Cys Ser Val Leu Thr Lys Asn Arg Ile Tyr Ala Gly 
    210                 215                 220                 


Gly Glu His Tyr Arg Cys Glu Glu Phe Gly Lys Val Phe Asn Gln Cys 
225                 230                 235                 240 


Ser His Leu Thr Glu His Glu His Gly Thr Glu Glu Lys Pro Cys Lys 
                245                 250                 255     


Tyr Glu Glu Cys Ser Ser Val Phe Ile Ser Cys Ser Ser Leu Ser Asn 
            260                 265                 270         


Gln Gln Met Ile Leu Ala Gly Glu Lys Leu Ser Lys Cys Glu Thr Trp 
        275                 280                 285             


Tyr Lys Gly Phe Asn His Ser Pro Asn Pro Ser Lys His Gln Arg Asn 
    290                 295                 300                 


Glu Ile Gly Gly Lys Pro Phe Lys Cys Glu Glu Cys Asp Ser Ile Phe 
305                 310                 315                 320 


Lys Trp Phe Ser Asp Leu Thr Lys His Lys Arg Ile His Thr Gly Glu 
                325                 330                 335     


Lys Pro Tyr Lys Cys Asp Glu Cys Gly Lys Ala Tyr Thr Gln Ser Ser 
            340                 345                 350         


His Leu Ser Glu His Arg Arg Ile His Thr Gly Glu Lys Pro Tyr Gln 
        355                 360                 365             


Cys Glu Glu Cys Gly Lys Val Phe Arg Thr Cys Ser Ser Leu Ser Asn 
    370                 375                 380                 


His Lys Arg Thr His Ser Glu Glu Lys Pro Tyr Thr Cys Glu Glu Cys 
385                 390                 395                 400 


Gly Asn Ile Phe Lys Gln Leu Ser Asp Leu Thr Lys His Lys Lys Thr 
                405                 410                 415     


His Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly Lys Asn Phe 
            420                 425                 430         


Thr Gln Ser Ser Asn Leu Ile Val His Lys Arg Ile His Thr Gly Glu 
        435                 440                 445             


Lys Pro Tyr Lys Cys Glu Glu Cys Gly Arg Val Phe Met Trp Phe Ser 
    450                 455                 460                 


Asp Ile Thr Lys His Lys Lys Thr His Thr Gly Glu Lys Pro Tyr Lys 
465                 470                 475                 480 


Cys Asp Glu Cys Gly Lys Asn Phe Thr Gln Ser Ser Asn Leu Ile Val 
                485                 490                 495     


His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Lys Cys 
            500                 505                 510         


Gly Lys Ala Phe Thr Gln Phe Ser His Leu Thr Val His Glu Ser Ile 
        515                 520                 525             


His Thr 
    530 

<210>  2690
<211>  2356
<212>  DNA
<213>  Homo sapiens

<400>  2690
gtcccgacag agctccactt cctgtccccg cggctctgtg tcccctgcta gccgtaggtc     60

gtgtgacccg caggcaccgg gagatccaga agtgaaacgc caggctctct ggaggccagg    120

agatgactct gttgacgttc agggatgtgg ccatagaatt ctccctggag gagtggaaat    180

gcctggacct cgctcagcag aatttgtaca gggatgtgat gttggagaac tacagaaact    240

tgttctccgt tggtctcact gtctgtaagc caggcctgat cacctgcctg gagcaacgaa    300

aagagccctg gaatgtgaag agacaggagg cagcagacgg acatccagct atgtcttctc    360

attttaccca agaccttctg ccagagcagg gcatacaaga tgcattccca aaaagaatac    420

tgagaggata tggaaattgt ggccttgata atttatattt aaggaaagac tgggaaagtt    480

tagatgagtg taagttgcaa aaagattata atggacttaa ccaatgttca tcaactaccc    540

atagcaaaat ctttcaatat aataaatatg ttaaaatctt tgataacttt tcaaatttac    600

atagacgtaa tataagtaat actggagaga aacctttcaa atgtcaagaa tgtggcaaat    660

cctttcaaat gctctcattc ctaactgaac atcagaaaat tcacactgga aaaaaattcc    720

aaaaatgtgg agaatgtggc aaaaccttta tccagtgctc acactttact gaacctgaga    780

acattgacac tggagagaaa ccttacaagt gtcaagaatg taacaacgtc attaaaactt    840

gctcagtcct tactaaaaat agaatttatg ccggagggga acattacaga tgtgaagaat    900

ttggcaaagt atttaaccag tgctcccacc ttactgaaca tgagcatggt actgaggaaa    960

aaccctgcaa atatgaagag tgcagcagtg tctttatctc ttgctcaagc ctttctaatc   1020

aacagatgat tcttgctgga gagaagctct ccaaatgtga aacatggtac aaaggtttta   1080

accacagccc aaatccttcc aaacaccaga gaaatgagat tggagggaaa cctttcaaat   1140

gtgaggaatg tgacagcatc ttcaagtggt tctcagacct tactaaacat aagagaattc   1200

acactggtga gaaaccatac aaatgtgacg aatgtgggaa agcctataca cagtcctcac   1260

acctcagtga acacaggagg attcacaccg gagagaaacc ctaccaatgt gaagaatgtg   1320

ggaaggtctt cagaacttgc tcaagccttt ctaaccataa gagaactcat tctgaagaaa   1380

aaccctacac gtgtgaagaa tgtggcaaca tctttaagca gttatcagac ctcactaagc   1440

ataagaaaac ccatactgga gagaagccct acaaatgtga cgaatgtgga aaaaacttta   1500

cccagtcctc caaccttatt gtacataaga gaattcatac tggagagaaa ccctacaagt   1560

gtgaagaatg tggcagagtc ttcatgtggt tctcagacat taccaaacat aagaaaaccc   1620

atactggaga gaaaccctac aaatgtgacg aatgtggaaa aaactttacc cagtcctcaa   1680

accttattgt acataagaga attcatactg gagagaaacc ctacaagtgt gaaaagtgtg   1740

gcaaagcctt cacccagttc tcacacctga ctgtacatga aagcattcat acttgagaaa   1800

aaaataaaca aatataaaaa taggcaaagc cgttagtatc tgctcgcatc ccactttaca   1860

tcagagttca gacttaataa agttatcata aatgtaatta ctattgaaag acctttcatg   1920

aaatataagt ctccagagca cacaagagta tttcttctga aaaaaatgtt acaattatac   1980

tagatggaag acttgcatca gttgcttaaa ctttcagaaa atttgtagag aaacccaaca   2040

aatctcataa atgtggaata acatttgttc aaaaatgata gcttagaaaa cactagagtt   2100

catactaaaa gatattttgc aaatacacta aatgggaaaa ataagcaagg acacgttcag   2160

aaatgacact gaatccctgt gttgagtcta cagagacatc tagacttaaa atagatcatt   2220

tatatttaag tttaaaagga ggatgagact gagtttttgt agagttataa ttacattcaa   2280

aatatacttt tttgcattga aaaaatgtta aatttttgaa aagcgaatat tgatgtcatt   2340

ctattctcaa atcagt                                                   2356


<210>  2691
<211>  557
<212>  PRT
<213>  Homo sapiens

<400>  2691


Met Thr Leu Leu Thr Phe Arg Asp Val Ala Ile Glu Phe Ser Leu Glu 
1               5                   10                  15      


Glu Trp Lys Cys Leu Asp Leu Ala Gln Gln Asn Leu Tyr Arg Asp Val 
            20                  25                  30          


Met Leu Glu Asn Tyr Arg Asn Leu Phe Ser Val Gly Leu Thr Val Cys 
        35                  40                  45              


Lys Pro Gly Leu Ile Thr Cys Leu Glu Gln Arg Lys Glu Pro Trp Asn 
    50                  55                  60                  


Val Lys Arg Gln Glu Ala Ala Asp Gly His Pro Ala Met Ser Ser His 
65                  70                  75                  80  


Phe Thr Gln Asp Leu Leu Pro Glu Gln Gly Ile Gln Asp Ala Phe Pro 
                85                  90                  95      


Lys Arg Ile Leu Arg Gly Tyr Gly Asn Cys Gly Leu Asp Asn Leu Tyr 
            100                 105                 110         


Leu Arg Lys Asp Trp Glu Ser Leu Asp Glu Cys Lys Leu Gln Lys Asp 
        115                 120                 125             


Tyr Asn Gly Leu Asn Gln Cys Ser Ser Thr Thr His Ser Lys Ile Phe 
    130                 135                 140                 


Gln Tyr Asn Lys Tyr Val Lys Ile Phe Asp Asn Phe Ser Asn Leu His 
145                 150                 155                 160 


Arg Arg Asn Ile Ser Asn Thr Gly Glu Lys Pro Phe Lys Cys Gln Glu 
                165                 170                 175     


Cys Gly Lys Ser Phe Gln Met Leu Ser Phe Leu Thr Glu His Gln Lys 
            180                 185                 190         


Ile His Thr Gly Lys Lys Phe Gln Lys Cys Gly Glu Cys Gly Lys Thr 
        195                 200                 205             


Phe Ile Gln Cys Ser His Phe Thr Glu Pro Glu Asn Ile Asp Thr Gly 
    210                 215                 220                 


Glu Lys Pro Tyr Lys Cys Gln Glu Cys Asn Asn Val Ile Lys Thr Cys 
225                 230                 235                 240 


Ser Val Leu Thr Lys Asn Arg Ile Tyr Ala Gly Gly Glu His Tyr Arg 
                245                 250                 255     


Cys Glu Glu Phe Gly Lys Val Phe Asn Gln Cys Ser His Leu Thr Glu 
            260                 265                 270         


His Glu His Gly Thr Glu Glu Lys Pro Cys Lys Tyr Glu Glu Cys Ser 
        275                 280                 285             


Ser Val Phe Ile Ser Cys Ser Ser Leu Ser Asn Gln Gln Met Ile Leu 
    290                 295                 300                 


Ala Gly Glu Lys Leu Ser Lys Cys Glu Thr Trp Tyr Lys Gly Phe Asn 
305                 310                 315                 320 


His Ser Pro Asn Pro Ser Lys His Gln Arg Asn Glu Ile Gly Gly Lys 
                325                 330                 335     


Pro Phe Lys Cys Glu Glu Cys Asp Ser Ile Phe Lys Trp Phe Ser Asp 
            340                 345                 350         


Leu Thr Lys His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys 
        355                 360                 365             


Asp Glu Cys Gly Lys Ala Tyr Thr Gln Ser Ser His Leu Ser Glu His 
    370                 375                 380                 


Arg Arg Ile His Thr Gly Glu Lys Pro Tyr Gln Cys Glu Glu Cys Gly 
385                 390                 395                 400 


Lys Val Phe Arg Thr Cys Ser Ser Leu Ser Asn His Lys Arg Thr His 
                405                 410                 415     


Ser Glu Glu Lys Pro Tyr Thr Cys Glu Glu Cys Gly Asn Ile Phe Lys 
            420                 425                 430         


Gln Leu Ser Asp Leu Thr Lys His Lys Lys Thr His Thr Gly Glu Lys 
        435                 440                 445             


Pro Tyr Lys Cys Asp Glu Cys Gly Lys Asn Phe Thr Gln Ser Ser Asn 
    450                 455                 460                 


Leu Ile Val His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys 
465                 470                 475                 480 


Glu Glu Cys Gly Arg Val Phe Met Trp Phe Ser Asp Ile Thr Lys His 
                485                 490                 495     


Lys Lys Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly 
            500                 505                 510         


Lys Asn Phe Thr Gln Ser Ser Asn Leu Ile Val His Lys Arg Ile His 
        515                 520                 525             


Thr Gly Glu Lys Pro Tyr Lys Cys Glu Lys Cys Gly Lys Ala Phe Thr 
    530                 535                 540                 


Gln Phe Ser His Leu Thr Val His Glu Ser Ile His Thr 
545                 550                 555         

<210>  2692
<211>  2560
<212>  DNA
<213>  Homo sapiens

<400>  2692
gtcccgacag agctccactt cctgtccccg cggctctgtg tcccctgcta gccgtaggtc     60

gtgtgacccg caggcaccgg gagatccaga agtgaaacgc caggctctct ggaggccagg    120

agatgactct gttgacgttc agggatgtgg ccatagaatt ctccctggag gagtggaaat    180

gcctggacct cgctcagcag aatttgtaca gggatgtgat gttggagaac tacagaaact    240

tgttctccgt tggtctcact gtctgtaagc caggcctgat cacctgcctg gagcaacgaa    300

aagagccctg gaatgtgaag agacaggagg cagcagacgg acatccaggc tggaagtgca    360

gtggtgtgat cgtggctcac tgcggcctcc acttcccagg ttcagagatg ggatttcacc    420

atgctactca ggcttgtctt gaactcctgg gctcaagcga tctgcctgcc tcagcctccc    480

aaagtgctgg gattacaggt gtgaaccacc gtgcccagcc aggcctcaat gtttctgtgg    540

acaaattcac tgctatgtct tctcatttta cccaagacct tctgccagag cagggcatac    600

aagatgcatt cccaaaaaga atactgagag gatatggaaa ttgtggcctt gataatttat    660

atttaaggaa agactgggaa agtttagatg agtgtaagtt gcaaaaagat tataatggac    720

ttaaccaatg ttcatcaact acccatagca aaatctttca atataataaa tatgttaaaa    780

tctttgataa cttttcaaat ttacatagac gtaatataag taatactgga gagaaacctt    840

tcaaatgtca agaatgtggc aaatcctttc aaatgctctc attcctaact gaacatcaga    900

aaattcacac tggaaaaaaa ttccaaaaat gtggagaatg tggcaaaacc tttatccagt    960

gctcacactt tactgaacct gagaacattg acactggaga gaaaccttac aagtgtcaag   1020

aatgtaacaa cgtcattaaa acttgctcag tccttactaa aaatagaatt tatgccggag   1080

gggaacatta cagatgtgaa gaatttggca aagtatttaa ccagtgctcc caccttactg   1140

aacatgagca tggtactgag gaaaaaccct gcaaatatga agagtgcagc agtgtcttta   1200

tctcttgctc aagcctttct aatcaacaga tgattcttgc tggagagaag ctctccaaat   1260

gtgaaacatg gtacaaaggt tttaaccaca gcccaaatcc ttccaaacac cagagaaatg   1320

agattggagg gaaacctttc aaatgtgagg aatgtgacag catcttcaag tggttctcag   1380

accttactaa acataagaga attcacactg gtgagaaacc atacaaatgt gacgaatgtg   1440

ggaaagccta tacacagtcc tcacacctca gtgaacacag gaggattcac accggagaga   1500

aaccctacca atgtgaagaa tgtgggaagg tcttcagaac ttgctcaagc ctttctaacc   1560

ataagagaac tcattctgaa gaaaaaccct acacgtgtga agaatgtggc aacatcttta   1620

agcagttatc agacctcact aagcataaga aaacccatac tggagagaag ccctacaaat   1680

gtgacgaatg tggaaaaaac tttacccagt cctccaacct tattgtacat aagagaattc   1740

atactggaga gaaaccctac aagtgtgaag aatgtggcag agtcttcatg tggttctcag   1800

acattaccaa acataagaaa acccatactg gagagaaacc ctacaaatgt gacgaatgtg   1860

gaaaaaactt tacccagtcc tcaaacctta ttgtacataa gagaattcat actggagaga   1920

aaccctacaa gtgtgaaaag tgtggcaaag ccttcaccca gttctcacac ctgactgtac   1980

atgaaagcat tcatacttga gaaaaaaata aacaaatata aaaataggca aagccgttag   2040

tatctgctcg catcccactt tacatcagag ttcagactta ataaagttat cataaatgta   2100

attactattg aaagaccttt catgaaatat aagtctccag agcacacaag agtatttctt   2160

ctgaaaaaaa tgttacaatt atactagatg gaagacttgc atcagttgct taaactttca   2220

gaaaatttgt agagaaaccc aacaaatctc ataaatgtgg aataacattt gttcaaaaat   2280

gatagcttag aaaacactag agttcatact aaaagatatt ttgcaaatac actaaatggg   2340

aaaaataagc aaggacacgt tcagaaatga cactgaatcc ctgtgttgag tctacagaga   2400

catctagact taaaatagat catttatatt taagtttaaa aggaggatga gactgagttt   2460

ttgtagagtt ataattacat tcaaaatata cttttttgca ttgaaaaaat gttaaatttt   2520

tgaaaagcga atattgatgt cattctattc tcaaatcagt                         2560


<210>  2693
<211>  625
<212>  PRT
<213>  Homo sapiens

<400>  2693


Met Thr Leu Leu Thr Phe Arg Asp Val Ala Ile Glu Phe Ser Leu Glu 
1               5                   10                  15      


Glu Trp Lys Cys Leu Asp Leu Ala Gln Gln Asn Leu Tyr Arg Asp Val 
            20                  25                  30          


Met Leu Glu Asn Tyr Arg Asn Leu Phe Ser Val Gly Leu Thr Val Cys 
        35                  40                  45              


Lys Pro Gly Leu Ile Thr Cys Leu Glu Gln Arg Lys Glu Pro Trp Asn 
    50                  55                  60                  


Val Lys Arg Gln Glu Ala Ala Asp Gly His Pro Gly Trp Lys Cys Ser 
65                  70                  75                  80  


Gly Val Ile Val Ala His Cys Gly Leu His Phe Pro Gly Ser Glu Met 
                85                  90                  95      


Gly Phe His His Ala Thr Gln Ala Cys Leu Glu Leu Leu Gly Ser Ser 
            100                 105                 110         


Asp Leu Pro Ala Ser Ala Ser Gln Ser Ala Gly Ile Thr Gly Val Asn 
        115                 120                 125             


His Arg Ala Gln Pro Gly Leu Asn Val Ser Val Asp Lys Phe Thr Ala 
    130                 135                 140                 


Met Ser Ser His Phe Thr Gln Asp Leu Leu Pro Glu Gln Gly Ile Gln 
145                 150                 155                 160 


Asp Ala Phe Pro Lys Arg Ile Leu Arg Gly Tyr Gly Asn Cys Gly Leu 
                165                 170                 175     


Asp Asn Leu Tyr Leu Arg Lys Asp Trp Glu Ser Leu Asp Glu Cys Lys 
            180                 185                 190         


Leu Gln Lys Asp Tyr Asn Gly Leu Asn Gln Cys Ser Ser Thr Thr His 
        195                 200                 205             


Ser Lys Ile Phe Gln Tyr Asn Lys Tyr Val Lys Ile Phe Asp Asn Phe 
    210                 215                 220                 


Ser Asn Leu His Arg Arg Asn Ile Ser Asn Thr Gly Glu Lys Pro Phe 
225                 230                 235                 240 


Lys Cys Gln Glu Cys Gly Lys Ser Phe Gln Met Leu Ser Phe Leu Thr 
                245                 250                 255     


Glu His Gln Lys Ile His Thr Gly Lys Lys Phe Gln Lys Cys Gly Glu 
            260                 265                 270         


Cys Gly Lys Thr Phe Ile Gln Cys Ser His Phe Thr Glu Pro Glu Asn 
        275                 280                 285             


Ile Asp Thr Gly Glu Lys Pro Tyr Lys Cys Gln Glu Cys Asn Asn Val 
    290                 295                 300                 


Ile Lys Thr Cys Ser Val Leu Thr Lys Asn Arg Ile Tyr Ala Gly Gly 
305                 310                 315                 320 


Glu His Tyr Arg Cys Glu Glu Phe Gly Lys Val Phe Asn Gln Cys Ser 
                325                 330                 335     


His Leu Thr Glu His Glu His Gly Thr Glu Glu Lys Pro Cys Lys Tyr 
            340                 345                 350         


Glu Glu Cys Ser Ser Val Phe Ile Ser Cys Ser Ser Leu Ser Asn Gln 
        355                 360                 365             


Gln Met Ile Leu Ala Gly Glu Lys Leu Ser Lys Cys Glu Thr Trp Tyr 
    370                 375                 380                 


Lys Gly Phe Asn His Ser Pro Asn Pro Ser Lys His Gln Arg Asn Glu 
385                 390                 395                 400 


Ile Gly Gly Lys Pro Phe Lys Cys Glu Glu Cys Asp Ser Ile Phe Lys 
                405                 410                 415     


Trp Phe Ser Asp Leu Thr Lys His Lys Arg Ile His Thr Gly Glu Lys 
            420                 425                 430         


Pro Tyr Lys Cys Asp Glu Cys Gly Lys Ala Tyr Thr Gln Ser Ser His 
        435                 440                 445             


Leu Ser Glu His Arg Arg Ile His Thr Gly Glu Lys Pro Tyr Gln Cys 
    450                 455                 460                 


Glu Glu Cys Gly Lys Val Phe Arg Thr Cys Ser Ser Leu Ser Asn His 
465                 470                 475                 480 


Lys Arg Thr His Ser Glu Glu Lys Pro Tyr Thr Cys Glu Glu Cys Gly 
                485                 490                 495     


Asn Ile Phe Lys Gln Leu Ser Asp Leu Thr Lys His Lys Lys Thr His 
            500                 505                 510         


Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly Lys Asn Phe Thr 
        515                 520                 525             


Gln Ser Ser Asn Leu Ile Val His Lys Arg Ile His Thr Gly Glu Lys 
    530                 535                 540                 


Pro Tyr Lys Cys Glu Glu Cys Gly Arg Val Phe Met Trp Phe Ser Asp 
545                 550                 555                 560 


Ile Thr Lys His Lys Lys Thr His Thr Gly Glu Lys Pro Tyr Lys Cys 
                565                 570                 575     


Asp Glu Cys Gly Lys Asn Phe Thr Gln Ser Ser Asn Leu Ile Val His 
            580                 585                 590         


Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Lys Cys Gly 
        595                 600                 605             


Lys Ala Phe Thr Gln Phe Ser His Leu Thr Val His Glu Ser Ile His 
    610                 615                 620                 


Thr 
625 

<210>  2694
<211>  2502
<212>  DNA
<213>  Homo sapiens

<400>  2694
gtcccgacag agctccactt cctgtccccg cggctctgtg tcccctgcta gccgtaggtc     60

gtgtgacccg caggcaccgg gagatccaga agtgaaacgc caggctctct ggaggccagg    120

agatgactct gttgacgttc agggatgtgg ccatagaatt ctccctggag gagtggaaat    180

gcctggacct cgctcagcag aatttgtaca gggatgtgat gttggagaac tacagaaact    240

tgttctccgt tggtctcact gtctgtaagc caggcctgat cacctgcctg gagcaacgaa    300

aagagccctg gaatgtgaag agacaggagg cagcagacgg acatccagca tccgcaaacg    360

tttagcttgt ctttatatct tgacaattgt gaataatgct gcagtgaaca tgagggagca    420

gataattctt caagatgctg cttttattcc cttcagttat tatatacaca gaagtgtgat    480

tgctgcgttg caggctatgt cttctcattt tacccaagac cttctgccag agcagggcat    540

acaagatgca ttcccaaaaa gaatactgag aggatatgga aattgtggcc ttgataattt    600

atatttaagg aaagactggg aaagtttaga tgagtgtaag ttgcaaaaag attataatgg    660

acttaaccaa tgttcatcaa ctacccatag caaaatcttt caatataata aatatgttaa    720

aatctttgat aacttttcaa atttacatag acgtaatata agtaatactg gagagaaacc    780

tttcaaatgt caagaatgtg gcaaatcctt tcaaatgctc tcattcctaa ctgaacatca    840

gaaaattcac actggaaaaa aattccaaaa atgtggagaa tgtggcaaaa cctttatcca    900

gtgctcacac tttactgaac ctgagaacat tgacactgga gagaaacctt acaagtgtca    960

agaatgtaac aacgtcatta aaacttgctc agtccttact aaaaatagaa tttatgccgg   1020

aggggaacat tacagatgtg aagaatttgg caaagtattt aaccagtgct cccaccttac   1080

tgaacatgag catggtactg aggaaaaacc ctgcaaatat gaagagtgca gcagtgtctt   1140

tatctcttgc tcaagccttt ctaatcaaca gatgattctt gctggagaga agctctccaa   1200

atgtgaaaca tggtacaaag gttttaacca cagcccaaat ccttccaaac accagagaaa   1260

tgagattgga gggaaacctt tcaaatgtga ggaatgtgac agcatcttca agtggttctc   1320

agaccttact aaacataaga gaattcacac tggtgagaaa ccatacaaat gtgacgaatg   1380

tgggaaagcc tatacacagt cctcacacct cagtgaacac aggaggattc acaccggaga   1440

gaaaccctac caatgtgaag aatgtgggaa ggtcttcaga acttgctcaa gcctttctaa   1500

ccataagaga actcattctg aagaaaaacc ctacacgtgt gaagaatgtg gcaacatctt   1560

taagcagtta tcagacctca ctaagcataa gaaaacccat actggagaga agccctacaa   1620

atgtgacgaa tgtggaaaaa actttaccca gtcctccaac cttattgtac ataagagaat   1680

tcatactgga gagaaaccct acaagtgtga agaatgtggc agagtcttca tgtggttctc   1740

agacattacc aaacataaga aaacccatac tggagagaaa ccctacaaat gtgacgaatg   1800

tggaaaaaac tttacccagt cctcaaacct tattgtacat aagagaattc atactggaga   1860

gaaaccctac aagtgtgaaa agtgtggcaa agccttcacc cagttctcac acctgactgt   1920

acatgaaagc attcatactt gagaaaaaaa taaacaaata taaaaatagg caaagccgtt   1980

agtatctgct cgcatcccac tttacatcag agttcagact taataaagtt atcataaatg   2040

taattactat tgaaagacct ttcatgaaat ataagtctcc agagcacaca agagtatttc   2100

ttctgaaaaa aatgttacaa ttatactaga tggaagactt gcatcagttg cttaaacttt   2160

cagaaaattt gtagagaaac ccaacaaatc tcataaatgt ggaataacat ttgttcaaaa   2220

atgatagctt agaaaacact agagttcata ctaaaagata ttttgcaaat acactaaatg   2280

ggaaaaataa gcaaggacac gttcagaaat gacactgaat ccctgtgttg agtctacaga   2340

gacatctaga cttaaaatag atcatttata tttaagttta aaaggaggat gagactgagt   2400

ttttgtagag ttataattac attcaaaata tacttttttg cattgaaaaa atgttaaatt   2460

tttgaaaagc gaatattgat gtcattctat tctcaaatca gt                      2502


<210>  2695
<211>  510
<212>  PRT
<213>  Homo sapiens

<400>  2695


Met Arg Glu Gln Ile Ile Leu Gln Asp Ala Ala Phe Ile Pro Phe Ser 
1               5                   10                  15      


Tyr Tyr Ile His Arg Ser Val Ile Ala Ala Leu Gln Ala Met Ser Ser 
            20                  25                  30          


His Phe Thr Gln Asp Leu Leu Pro Glu Gln Gly Ile Gln Asp Ala Phe 
        35                  40                  45              


Pro Lys Arg Ile Leu Arg Gly Tyr Gly Asn Cys Gly Leu Asp Asn Leu 
    50                  55                  60                  


Tyr Leu Arg Lys Asp Trp Glu Ser Leu Asp Glu Cys Lys Leu Gln Lys 
65                  70                  75                  80  


Asp Tyr Asn Gly Leu Asn Gln Cys Ser Ser Thr Thr His Ser Lys Ile 
                85                  90                  95      


Phe Gln Tyr Asn Lys Tyr Val Lys Ile Phe Asp Asn Phe Ser Asn Leu 
            100                 105                 110         


His Arg Arg Asn Ile Ser Asn Thr Gly Glu Lys Pro Phe Lys Cys Gln 
        115                 120                 125             


Glu Cys Gly Lys Ser Phe Gln Met Leu Ser Phe Leu Thr Glu His Gln 
    130                 135                 140                 


Lys Ile His Thr Gly Lys Lys Phe Gln Lys Cys Gly Glu Cys Gly Lys 
145                 150                 155                 160 


Thr Phe Ile Gln Cys Ser His Phe Thr Glu Pro Glu Asn Ile Asp Thr 
                165                 170                 175     


Gly Glu Lys Pro Tyr Lys Cys Gln Glu Cys Asn Asn Val Ile Lys Thr 
            180                 185                 190         


Cys Ser Val Leu Thr Lys Asn Arg Ile Tyr Ala Gly Gly Glu His Tyr 
        195                 200                 205             


Arg Cys Glu Glu Phe Gly Lys Val Phe Asn Gln Cys Ser His Leu Thr 
    210                 215                 220                 


Glu His Glu His Gly Thr Glu Glu Lys Pro Cys Lys Tyr Glu Glu Cys 
225                 230                 235                 240 


Ser Ser Val Phe Ile Ser Cys Ser Ser Leu Ser Asn Gln Gln Met Ile 
                245                 250                 255     


Leu Ala Gly Glu Lys Leu Ser Lys Cys Glu Thr Trp Tyr Lys Gly Phe 
            260                 265                 270         


Asn His Ser Pro Asn Pro Ser Lys His Gln Arg Asn Glu Ile Gly Gly 
        275                 280                 285             


Lys Pro Phe Lys Cys Glu Glu Cys Asp Ser Ile Phe Lys Trp Phe Ser 
    290                 295                 300                 


Asp Leu Thr Lys His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys 
305                 310                 315                 320 


Cys Asp Glu Cys Gly Lys Ala Tyr Thr Gln Ser Ser His Leu Ser Glu 
                325                 330                 335     


His Arg Arg Ile His Thr Gly Glu Lys Pro Tyr Gln Cys Glu Glu Cys 
            340                 345                 350         


Gly Lys Val Phe Arg Thr Cys Ser Ser Leu Ser Asn His Lys Arg Thr 
        355                 360                 365             


His Ser Glu Glu Lys Pro Tyr Thr Cys Glu Glu Cys Gly Asn Ile Phe 
    370                 375                 380                 


Lys Gln Leu Ser Asp Leu Thr Lys His Lys Lys Thr His Thr Gly Glu 
385                 390                 395                 400 


Lys Pro Tyr Lys Cys Asp Glu Cys Gly Lys Asn Phe Thr Gln Ser Ser 
                405                 410                 415     


Asn Leu Ile Val His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys 
            420                 425                 430         


Cys Glu Glu Cys Gly Arg Val Phe Met Trp Phe Ser Asp Ile Thr Lys 
        435                 440                 445             


His Lys Lys Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys 
    450                 455                 460                 


Gly Lys Asn Phe Thr Gln Ser Ser Asn Leu Ile Val His Lys Arg Ile 
465                 470                 475                 480 


His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Lys Cys Gly Lys Ala Phe 
                485                 490                 495     


Thr Gln Phe Ser His Leu Thr Val His Glu Ser Ile His Thr 
            500                 505                 510 

<210>  2696
<211>  2122
<212>  DNA
<213>  Homo sapiens

<400>  2696
ttccgggatc tagcggggcc tttgtcccga cagagctcca cttcctgtcc ccgcggctct     60

gtgtcccctg ctagccgtag gtcgtgtgac ccgcaggcac cgggagatcc agaactatgt    120

cttctcattt tacccaagac cttctgccag agcagggcat acaagatgca ttcccaaaaa    180

gaatactgag aggatatgga aattgtggcc ttgataattt atatttaagg aaagactggg    240

aaagtttaga tgagtgtaag ttgcaaaaag attataatgg acttaaccaa tgttcatcaa    300

ctacccatag caaaatcttt caatataata aatatgttaa aatctttgat aacttttcaa    360

atttacatag acgtaatata agtaatactg gagagaaacc tttcaaatgt caagaatgtg    420

gcaaatcctt tcaaatgctc tcattcctaa ctgaacatca gaaaattcac actggaaaaa    480

aattccaaaa atgtggagaa tgtggcaaaa cctttatcca gtgctcacac tttactgaac    540

ctgagaacat tgacactgga gagaaacctt acaagtgtca agaatgtaac aacgtcatta    600

aaacttgctc agtccttact aaaaatagaa tttatgccgg aggggaacat tacagatgtg    660

aagaatttgg caaagtattt aaccagtgct cccaccttac tgaacatgag catggtactg    720

aggaaaaacc ctgcaaatat gaagagtgca gcagtgtctt tatctcttgc tcaagccttt    780

ctaatcaaca gatgattctt gctggagaga agctctccaa atgtgaaaca tggtacaaag    840

gttttaacca cagcccaaat ccttccaaac accagagaaa tgagattgga gggaaacctt    900

tcaaatgtga ggaatgtgac agcatcttca agtggttctc agaccttact aaacataaga    960

gaattcacac tggtgagaaa ccatacaaat gtgacgaatg tgggaaagcc tatacacagt   1020

cctcacacct cagtgaacac aggaggattc acaccggaga gaaaccctac caatgtgaag   1080

aatgtgggaa ggtcttcaga acttgctcaa gcctttctaa ccataagaga actcattctg   1140

aagaaaaacc ctacacgtgt gaagaatgtg gcaacatctt taagcagtta tcagacctca   1200

ctaagcataa gaaaacccat actggagaga agccctacaa atgtgacgaa tgtggaaaaa   1260

actttaccca gtcctccaac cttattgtac ataagagaat tcatactgga gagaaaccct   1320

acaagtgtga agaatgtggc agagtcttca tgtggttctc agacattacc aaacataaga   1380

aaacccatac tggagagaaa ccctacaaat gtgacgaatg tggaaaaaac tttacccagt   1440

cctcaaacct tattgtacat aagagaattc atactggaga gaaaccctac aagtgtgaaa   1500

agtgtggcaa agccttcacc cagttctcac acctgactgt acatgaaagc attcatactt   1560

gagaaaaaaa taaacaaata taaaaatagg caaagccgtt agtatctgct cgcatcccac   1620

tttacatcag agttcagact taataaagtt atcataaatg taattactat tgaaagacct   1680

ttcatgaaat ataagtctcc agagcacaca agagtatttc ttctgaaaaa aatgttacaa   1740

ttatactaga tggaagactt gcatcagttg cttaaacttt cagaaaattt gtagagaaac   1800

ccaacaaatc tcataaatgt ggaataacat ttgttcaaaa atgatagctt agaaaacact   1860

agagttcata ctaaaagata ttttgcaaat acactaaatg ggaaaaataa gcaaggacac   1920

gttcagaaat gacactgaat ccctgtgttg agtctacaga gacatctaga cttaaaatag   1980

atcatttata tttaagttta aaaggaggat gagactgagt ttttgtagag ttataattac   2040

attcaaaata tacttttttg cattgaaaaa atgttaaatt tttgaaaagc gaatattgat   2100

gtcattctat tctcaaatca gt                                            2122


<210>  2697
<211>  481
<212>  PRT
<213>  Homo sapiens

<400>  2697


Met Ser Ser His Phe Thr Gln Asp Leu Leu Pro Glu Gln Gly Ile Gln 
1               5                   10                  15      


Asp Ala Phe Pro Lys Arg Ile Leu Arg Gly Tyr Gly Asn Cys Gly Leu 
            20                  25                  30          


Asp Asn Leu Tyr Leu Arg Lys Asp Trp Glu Ser Leu Asp Glu Cys Lys 
        35                  40                  45              


Leu Gln Lys Asp Tyr Asn Gly Leu Asn Gln Cys Ser Ser Thr Thr His 
    50                  55                  60                  


Ser Lys Ile Phe Gln Tyr Asn Lys Tyr Val Lys Ile Phe Asp Asn Phe 
65                  70                  75                  80  


Ser Asn Leu His Arg Arg Asn Ile Ser Asn Thr Gly Glu Lys Pro Phe 
                85                  90                  95      


Lys Cys Gln Glu Cys Gly Lys Ser Phe Gln Met Leu Ser Phe Leu Thr 
            100                 105                 110         


Glu His Gln Lys Ile His Thr Gly Lys Lys Phe Gln Lys Cys Gly Glu 
        115                 120                 125             


Cys Gly Lys Thr Phe Ile Gln Cys Ser His Phe Thr Glu Pro Glu Asn 
    130                 135                 140                 


Ile Asp Thr Gly Glu Lys Pro Tyr Lys Cys Gln Glu Cys Asn Asn Val 
145                 150                 155                 160 


Ile Lys Thr Cys Ser Val Leu Thr Lys Asn Arg Ile Tyr Ala Gly Gly 
                165                 170                 175     


Glu His Tyr Arg Cys Glu Glu Phe Gly Lys Val Phe Asn Gln Cys Ser 
            180                 185                 190         


His Leu Thr Glu His Glu His Gly Thr Glu Glu Lys Pro Cys Lys Tyr 
        195                 200                 205             


Glu Glu Cys Ser Ser Val Phe Ile Ser Cys Ser Ser Leu Ser Asn Gln 
    210                 215                 220                 


Gln Met Ile Leu Ala Gly Glu Lys Leu Ser Lys Cys Glu Thr Trp Tyr 
225                 230                 235                 240 


Lys Gly Phe Asn His Ser Pro Asn Pro Ser Lys His Gln Arg Asn Glu 
                245                 250                 255     


Ile Gly Gly Lys Pro Phe Lys Cys Glu Glu Cys Asp Ser Ile Phe Lys 
            260                 265                 270         


Trp Phe Ser Asp Leu Thr Lys His Lys Arg Ile His Thr Gly Glu Lys 
        275                 280                 285             


Pro Tyr Lys Cys Asp Glu Cys Gly Lys Ala Tyr Thr Gln Ser Ser His 
    290                 295                 300                 


Leu Ser Glu His Arg Arg Ile His Thr Gly Glu Lys Pro Tyr Gln Cys 
305                 310                 315                 320 


Glu Glu Cys Gly Lys Val Phe Arg Thr Cys Ser Ser Leu Ser Asn His 
                325                 330                 335     


Lys Arg Thr His Ser Glu Glu Lys Pro Tyr Thr Cys Glu Glu Cys Gly 
            340                 345                 350         


Asn Ile Phe Lys Gln Leu Ser Asp Leu Thr Lys His Lys Lys Thr His 
        355                 360                 365             


Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly Lys Asn Phe Thr 
    370                 375                 380                 


Gln Ser Ser Asn Leu Ile Val His Lys Arg Ile His Thr Gly Glu Lys 
385                 390                 395                 400 


Pro Tyr Lys Cys Glu Glu Cys Gly Arg Val Phe Met Trp Phe Ser Asp 
                405                 410                 415     


Ile Thr Lys His Lys Lys Thr His Thr Gly Glu Lys Pro Tyr Lys Cys 
            420                 425                 430         


Asp Glu Cys Gly Lys Asn Phe Thr Gln Ser Ser Asn Leu Ile Val His 
        435                 440                 445             


Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Lys Cys Gly 
    450                 455                 460                 


Lys Ala Phe Thr Gln Phe Ser His Leu Thr Val His Glu Ser Ile His 
465                 470                 475                 480 


Thr 
    

<210>  2698
<211>  2558
<212>  DNA
<213>  Homo sapiens

<400>  2698
atcaggcaca tgtctggaga ggagaggacg gcttccggga tctagcgggg cctttgtccc     60

gacagagctc cacttcctgt ccccgcggct ctgtgtcccc tgctagccgt aggtcgtgtg    120

acccgcaggc accgggagat ccagaagtga aacgccaggc tctctggagg ccaggagatg    180

actctgttga cgttcaggga tgtggccata gaattctccc tggaggagtg gaaatgcctg    240

gacctcgctc agcagaattt gtacagggat gtgatgttgg agaactacag aaacttgttc    300

tccgttggtc tcactgtctg taagccaggc ctgatcacct gcctggagca acgaaaagag    360

ccctggaatg tgaagagaca ggaggcagca gacggacatc cagagatggg atttcaccat    420

gctactcagg cttgtcttga actcctgggc tcaagcgatc tgcctgcctc agcctcccaa    480

agtgctggga ttacaggtgt gaaccaccgt gcccagccag gcctcaatgt ttctgtggac    540

aaattcactg ctatgtcttc tcattttacc caagaccttc tgccagagca gggcatacaa    600

gatgcattcc caaaaagaat actgagagga tatggaaatt gtggccttga taatttatat    660

ttaaggaaag actgggaaag tttagatgag tgtaagttgc aaaaagatta taatggactt    720

aaccaatgtt catcaactac ccatagcaaa atctttcaat ataataaata tgttaaaatc    780

tttgataact tttcaaattt acatagacgt aatataagta atactggaga gaaacctttc    840

aaatgtcaag aatgtggcaa atcctttcaa atgctctcat tcctaactga acatcagaaa    900

attcacactg gaaaaaaatt ccaaaaatgt ggagaatgtg gcaaaacctt tatccagtgc    960

tcacacttta ctgaacctga gaacattgac actggagaga aaccttacaa gtgtcaagaa   1020

tgtaacaacg tcattaaaac ttgctcagtc cttactaaaa atagaattta tgccggaggg   1080

gaacattaca gatgtgaaga atttggcaaa gtatttaacc agtgctccca ccttactgaa   1140

catgagcatg gtactgagga aaaaccctgc aaatatgaag agtgcagcag tgtctttatc   1200

tcttgctcaa gcctttctaa tcaacagatg attcttgctg gagagaagct ctccaaatgt   1260

gaaacatggt acaaaggttt taaccacagc ccaaatcctt ccaaacacca gagaaatgag   1320

attggaggga aacctttcaa atgtgaggaa tgtgacagca tcttcaagtg gttctcagac   1380

cttactaaac ataagagaat tcacactggt gagaaaccat acaaatgtga cgaatgtggg   1440

aaagcctata cacagtcctc acacctcagt gaacacagga ggattcacac cggagagaaa   1500

ccctaccaat gtgaagaatg tgggaaggtc ttcagaactt gctcaagcct ttctaaccat   1560

aagagaactc attctgaaga aaaaccctac acgtgtgaag aatgtggcaa catctttaag   1620

cagttatcag acctcactaa gcataagaaa acccatactg gagagaagcc ctacaaatgt   1680

gacgaatgtg gaaaaaactt tacccagtcc tccaacctta ttgtacataa gagaattcat   1740

actggagaga aaccctacaa gtgtgaagaa tgtggcagag tcttcatgtg gttctcagac   1800

attaccaaac ataagaaaac ccatactgga gagaaaccct acaaatgtga cgaatgtgga   1860

aaaaacttta cccagtcctc aaaccttatt gtacataaga gaattcatac tggagagaaa   1920

ccctacaagt gtgaaaagtg tggcaaagcc ttcacccagt tctcacacct gactgtacat   1980

gaaagcattc atacttgaga aaaaaataaa caaatataaa aataggcaaa gccgttagta   2040

tctgctcgca tcccacttta catcagagtt cagacttaat aaagttatca taaatgtaat   2100

tactattgaa agacctttca tgaaatataa gtctccagag cacacaagag tatttcttct   2160

gaaaaaaatg ttacaattat actagatgga agacttgcat cagttgctta aactttcaga   2220

aaatttgtag agaaacccaa caaatctcat aaatgtggaa taacatttgt tcaaaaatga   2280

tagcttagaa aacactagag ttcatactaa aagatatttt gcaaatacac taaatgggaa   2340

aaataagcaa ggacacgttc agaaatgaca ctgaatccct gtgttgagtc tacagagaca   2400

tctagactta aaatagatca tttatattta agtttaaaag gaggatgaga ctgagttttt   2460

gtagagttat aattacattc aaaatatact tttttgcatt gaaaaaatgt taaatttttg   2520

aaaagcgaat attgatgtca ttctattctc aaatcagt                           2558


<210>  2699
<211>  606
<212>  PRT
<213>  Homo sapiens

<400>  2699


Met Thr Leu Leu Thr Phe Arg Asp Val Ala Ile Glu Phe Ser Leu Glu 
1               5                   10                  15      


Glu Trp Lys Cys Leu Asp Leu Ala Gln Gln Asn Leu Tyr Arg Asp Val 
            20                  25                  30          


Met Leu Glu Asn Tyr Arg Asn Leu Phe Ser Val Gly Leu Thr Val Cys 
        35                  40                  45              


Lys Pro Gly Leu Ile Thr Cys Leu Glu Gln Arg Lys Glu Pro Trp Asn 
    50                  55                  60                  


Val Lys Arg Gln Glu Ala Ala Asp Gly His Pro Glu Met Gly Phe His 
65                  70                  75                  80  


His Ala Thr Gln Ala Cys Leu Glu Leu Leu Gly Ser Ser Asp Leu Pro 
                85                  90                  95      


Ala Ser Ala Ser Gln Ser Ala Gly Ile Thr Gly Val Asn His Arg Ala 
            100                 105                 110         


Gln Pro Gly Leu Asn Val Ser Val Asp Lys Phe Thr Ala Met Ser Ser 
        115                 120                 125             


His Phe Thr Gln Asp Leu Leu Pro Glu Gln Gly Ile Gln Asp Ala Phe 
    130                 135                 140                 


Pro Lys Arg Ile Leu Arg Gly Tyr Gly Asn Cys Gly Leu Asp Asn Leu 
145                 150                 155                 160 


Tyr Leu Arg Lys Asp Trp Glu Ser Leu Asp Glu Cys Lys Leu Gln Lys 
                165                 170                 175     


Asp Tyr Asn Gly Leu Asn Gln Cys Ser Ser Thr Thr His Ser Lys Ile 
            180                 185                 190         


Phe Gln Tyr Asn Lys Tyr Val Lys Ile Phe Asp Asn Phe Ser Asn Leu 
        195                 200                 205             


His Arg Arg Asn Ile Ser Asn Thr Gly Glu Lys Pro Phe Lys Cys Gln 
    210                 215                 220                 


Glu Cys Gly Lys Ser Phe Gln Met Leu Ser Phe Leu Thr Glu His Gln 
225                 230                 235                 240 


Lys Ile His Thr Gly Lys Lys Phe Gln Lys Cys Gly Glu Cys Gly Lys 
                245                 250                 255     


Thr Phe Ile Gln Cys Ser His Phe Thr Glu Pro Glu Asn Ile Asp Thr 
            260                 265                 270         


Gly Glu Lys Pro Tyr Lys Cys Gln Glu Cys Asn Asn Val Ile Lys Thr 
        275                 280                 285             


Cys Ser Val Leu Thr Lys Asn Arg Ile Tyr Ala Gly Gly Glu His Tyr 
    290                 295                 300                 


Arg Cys Glu Glu Phe Gly Lys Val Phe Asn Gln Cys Ser His Leu Thr 
305                 310                 315                 320 


Glu His Glu His Gly Thr Glu Glu Lys Pro Cys Lys Tyr Glu Glu Cys 
                325                 330                 335     


Ser Ser Val Phe Ile Ser Cys Ser Ser Leu Ser Asn Gln Gln Met Ile 
            340                 345                 350         


Leu Ala Gly Glu Lys Leu Ser Lys Cys Glu Thr Trp Tyr Lys Gly Phe 
        355                 360                 365             


Asn His Ser Pro Asn Pro Ser Lys His Gln Arg Asn Glu Ile Gly Gly 
    370                 375                 380                 


Lys Pro Phe Lys Cys Glu Glu Cys Asp Ser Ile Phe Lys Trp Phe Ser 
385                 390                 395                 400 


Asp Leu Thr Lys His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys 
                405                 410                 415     


Cys Asp Glu Cys Gly Lys Ala Tyr Thr Gln Ser Ser His Leu Ser Glu 
            420                 425                 430         


His Arg Arg Ile His Thr Gly Glu Lys Pro Tyr Gln Cys Glu Glu Cys 
        435                 440                 445             


Gly Lys Val Phe Arg Thr Cys Ser Ser Leu Ser Asn His Lys Arg Thr 
    450                 455                 460                 


His Ser Glu Glu Lys Pro Tyr Thr Cys Glu Glu Cys Gly Asn Ile Phe 
465                 470                 475                 480 


Lys Gln Leu Ser Asp Leu Thr Lys His Lys Lys Thr His Thr Gly Glu 
                485                 490                 495     


Lys Pro Tyr Lys Cys Asp Glu Cys Gly Lys Asn Phe Thr Gln Ser Ser 
            500                 505                 510         


Asn Leu Ile Val His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys 
        515                 520                 525             


Cys Glu Glu Cys Gly Arg Val Phe Met Trp Phe Ser Asp Ile Thr Lys 
    530                 535                 540                 


His Lys Lys Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys 
545                 550                 555                 560 


Gly Lys Asn Phe Thr Gln Ser Ser Asn Leu Ile Val His Lys Arg Ile 
                565                 570                 575     


His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Lys Cys Gly Lys Ala Phe 
            580                 585                 590         


Thr Gln Phe Ser His Leu Thr Val His Glu Ser Ile His Thr 
        595                 600                 605     

<210>  2700
<211>  2627
<212>  DNA
<213>  Homo sapiens

<400>  2700
atcaggcaca tgtctggaga ggagaggacg gcttccggga tctagcgggg cctttgtccc     60

gacagagctc cacttcctgt ccccgcggct ctgtgtcccc tgctagccgt aggtcgtgtg    120

acccgcaggc accgggagat ccagaagtga aacgccaggc tctctggagg ccaggagatg    180

actctgttga cgttcaggga tgtggccata gaattctccc tggaggagtg gaaatgcctg    240

gacctcgctc agcagaattt gtacagggat gtgatgttgg agaactacag aaacttgttc    300

tccgttggtc tcactgtctg taagccaggc ctgatcacct gcctggagca acgaaaagag    360

ccctggaatg tgaagagaca ggaggcagca gacggacatc cagagatggg atttcaccat    420

gctactcagg cttgtcttga actcctgggc tcaagcgatc tgcctgcctc agcctcccaa    480

agtgctggga ttacaggtgt gaaccaccgt gcccagccag gcctcaatgt ttctgtggac    540

aaattcactg cactgtgctc acctggggtg ctgcaaactg tgaaatggtt tttagagttc    600

agatgcatct tctcactagc tatgtcttct cattttaccc aagaccttct gccagagcag    660

ggcatacaag atgcattccc aaaaagaata ctgagaggat atggaaattg tggccttgat    720

aatttatatt taaggaaaga ctgggaaagt ttagatgagt gtaagttgca aaaagattat    780

aatggactta accaatgttc atcaactacc catagcaaaa tctttcaata taataaatat    840

gttaaaatct ttgataactt ttcaaattta catagacgta atataagtaa tactggagag    900

aaacctttca aatgtcaaga atgtggcaaa tcctttcaaa tgctctcatt cctaactgaa    960

catcagaaaa ttcacactgg aaaaaaattc caaaaatgtg gagaatgtgg caaaaccttt   1020

atccagtgct cacactttac tgaacctgag aacattgaca ctggagagaa accttacaag   1080

tgtcaagaat gtaacaacgt cattaaaact tgctcagtcc ttactaaaaa tagaatttat   1140

gccggagggg aacattacag atgtgaagaa tttggcaaag tatttaacca gtgctcccac   1200

cttactgaac atgagcatgg tactgaggaa aaaccctgca aatatgaaga gtgcagcagt   1260

gtctttatct cttgctcaag cctttctaat caacagatga ttcttgctgg agagaagctc   1320

tccaaatgtg aaacatggta caaaggtttt aaccacagcc caaatccttc caaacaccag   1380

agaaatgaga ttggagggaa acctttcaaa tgtgaggaat gtgacagcat cttcaagtgg   1440

ttctcagacc ttactaaaca taagagaatt cacactggtg agaaaccata caaatgtgac   1500

gaatgtggga aagcctatac acagtcctca cacctcagtg aacacaggag gattcacacc   1560

ggagagaaac cctaccaatg tgaagaatgt gggaaggtct tcagaacttg ctcaagcctt   1620

tctaaccata agagaactca ttctgaagaa aaaccctaca cgtgtgaaga atgtggcaac   1680

atctttaagc agttatcaga cctcactaag cataagaaaa cccatactgg agagaagccc   1740

tacaaatgtg acgaatgtgg aaaaaacttt acccagtcct ccaaccttat tgtacataag   1800

agaattcata ctggagagaa accctacaag tgtgaagaat gtggcagagt cttcatgtgg   1860

ttctcagaca ttaccaaaca taagaaaacc catactggag agaaacccta caaatgtgac   1920

gaatgtggaa aaaactttac ccagtcctca aaccttattg tacataagag aattcatact   1980

ggagagaaac cctacaagtg tgaaaagtgt ggcaaagcct tcacccagtt ctcacacctg   2040

actgtacatg aaagcattca tacttgagaa aaaaataaac aaatataaaa ataggcaaag   2100

ccgttagtat ctgctcgcat cccactttac atcagagttc agacttaata aagttatcat   2160

aaatgtaatt actattgaaa gacctttcat gaaatataag tctccagagc acacaagagt   2220

atttcttctg aaaaaaatgt tacaattata ctagatggaa gacttgcatc agttgcttaa   2280

actttcagaa aatttgtaga gaaacccaac aaatctcata aatgtggaat aacatttgtt   2340

caaaaatgat agcttagaaa acactagagt tcatactaaa agatattttg caaatacact   2400

aaatgggaaa aataagcaag gacacgttca gaaatgacac tgaatccctg tgttgagtct   2460

acagagacat ctagacttaa aatagatcat ttatatttaa gtttaaaagg aggatgagac   2520

tgagtttttg tagagttata attacattca aaatatactt ttttgcattg aaaaaatgtt   2580

aaatttttga aaagcgaata ttgatgtcat tctattctca aatcagt                 2627


<210>  2701
<211>  629
<212>  PRT
<213>  Homo sapiens

<400>  2701


Met Thr Leu Leu Thr Phe Arg Asp Val Ala Ile Glu Phe Ser Leu Glu 
1               5                   10                  15      


Glu Trp Lys Cys Leu Asp Leu Ala Gln Gln Asn Leu Tyr Arg Asp Val 
            20                  25                  30          


Met Leu Glu Asn Tyr Arg Asn Leu Phe Ser Val Gly Leu Thr Val Cys 
        35                  40                  45              


Lys Pro Gly Leu Ile Thr Cys Leu Glu Gln Arg Lys Glu Pro Trp Asn 
    50                  55                  60                  


Val Lys Arg Gln Glu Ala Ala Asp Gly His Pro Glu Met Gly Phe His 
65                  70                  75                  80  


His Ala Thr Gln Ala Cys Leu Glu Leu Leu Gly Ser Ser Asp Leu Pro 
                85                  90                  95      


Ala Ser Ala Ser Gln Ser Ala Gly Ile Thr Gly Val Asn His Arg Ala 
            100                 105                 110         


Gln Pro Gly Leu Asn Val Ser Val Asp Lys Phe Thr Ala Leu Cys Ser 
        115                 120                 125             


Pro Gly Val Leu Gln Thr Val Lys Trp Phe Leu Glu Phe Arg Cys Ile 
    130                 135                 140                 


Phe Ser Leu Ala Met Ser Ser His Phe Thr Gln Asp Leu Leu Pro Glu 
145                 150                 155                 160 


Gln Gly Ile Gln Asp Ala Phe Pro Lys Arg Ile Leu Arg Gly Tyr Gly 
                165                 170                 175     


Asn Cys Gly Leu Asp Asn Leu Tyr Leu Arg Lys Asp Trp Glu Ser Leu 
            180                 185                 190         


Asp Glu Cys Lys Leu Gln Lys Asp Tyr Asn Gly Leu Asn Gln Cys Ser 
        195                 200                 205             


Ser Thr Thr His Ser Lys Ile Phe Gln Tyr Asn Lys Tyr Val Lys Ile 
    210                 215                 220                 


Phe Asp Asn Phe Ser Asn Leu His Arg Arg Asn Ile Ser Asn Thr Gly 
225                 230                 235                 240 


Glu Lys Pro Phe Lys Cys Gln Glu Cys Gly Lys Ser Phe Gln Met Leu 
                245                 250                 255     


Ser Phe Leu Thr Glu His Gln Lys Ile His Thr Gly Lys Lys Phe Gln 
            260                 265                 270         


Lys Cys Gly Glu Cys Gly Lys Thr Phe Ile Gln Cys Ser His Phe Thr 
        275                 280                 285             


Glu Pro Glu Asn Ile Asp Thr Gly Glu Lys Pro Tyr Lys Cys Gln Glu 
    290                 295                 300                 


Cys Asn Asn Val Ile Lys Thr Cys Ser Val Leu Thr Lys Asn Arg Ile 
305                 310                 315                 320 


Tyr Ala Gly Gly Glu His Tyr Arg Cys Glu Glu Phe Gly Lys Val Phe 
                325                 330                 335     


Asn Gln Cys Ser His Leu Thr Glu His Glu His Gly Thr Glu Glu Lys 
            340                 345                 350         


Pro Cys Lys Tyr Glu Glu Cys Ser Ser Val Phe Ile Ser Cys Ser Ser 
        355                 360                 365             


Leu Ser Asn Gln Gln Met Ile Leu Ala Gly Glu Lys Leu Ser Lys Cys 
    370                 375                 380                 


Glu Thr Trp Tyr Lys Gly Phe Asn His Ser Pro Asn Pro Ser Lys His 
385                 390                 395                 400 


Gln Arg Asn Glu Ile Gly Gly Lys Pro Phe Lys Cys Glu Glu Cys Asp 
                405                 410                 415     


Ser Ile Phe Lys Trp Phe Ser Asp Leu Thr Lys His Lys Arg Ile His 
            420                 425                 430         


Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly Lys Ala Tyr Thr 
        435                 440                 445             


Gln Ser Ser His Leu Ser Glu His Arg Arg Ile His Thr Gly Glu Lys 
    450                 455                 460                 


Pro Tyr Gln Cys Glu Glu Cys Gly Lys Val Phe Arg Thr Cys Ser Ser 
465                 470                 475                 480 


Leu Ser Asn His Lys Arg Thr His Ser Glu Glu Lys Pro Tyr Thr Cys 
                485                 490                 495     


Glu Glu Cys Gly Asn Ile Phe Lys Gln Leu Ser Asp Leu Thr Lys His 
            500                 505                 510         


Lys Lys Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly 
        515                 520                 525             


Lys Asn Phe Thr Gln Ser Ser Asn Leu Ile Val His Lys Arg Ile His 
    530                 535                 540                 


Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly Arg Val Phe Met 
545                 550                 555                 560 


Trp Phe Ser Asp Ile Thr Lys His Lys Lys Thr His Thr Gly Glu Lys 
                565                 570                 575     


Pro Tyr Lys Cys Asp Glu Cys Gly Lys Asn Phe Thr Gln Ser Ser Asn 
            580                 585                 590         


Leu Ile Val His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys 
        595                 600                 605             


Glu Lys Cys Gly Lys Ala Phe Thr Gln Phe Ser His Leu Thr Val His 
    610                 615                 620                 


Glu Ser Ile His Thr 
625                 

<210>  2702
<211>  2585
<212>  DNA
<213>  Homo sapiens

<400>  2702
aatcaggcac atgtctggag aggagaggac ggcttccggg atctagcggg gcctttgtcc     60

cgacagagct ccacttcctg tccccgcggc tctgtgtccc ctgctagccg taggtcgtgt    120

gacccgcagg caccgggaga tccagaagtg aaacgccagg ctctctggag gccaggagat    180

ggtgtgattt gtccagagaa tctttcctaa gaggaaatcc cagagaagca ggagaaagag    240

aaagaaatgg ctggtgctca gactctgttg acgttcaggg atgtggccat agaattctcc    300

ctggaggagt ggaaatgcct ggacctcgct cagcagaatt tgtacaggga tgtgatgttg    360

gagaactaca gaaacttgtt ctccgttggt ctcactgtct gtaagccagg cctgatcacc    420

tgcctggagc aacgaaaaga gccctggaat gtgaagagac aggaggcagc agacggacat    480

ccagagatgg gatttcacca tgctactcag gcttgtcttg aactcctggg ctcaagcgat    540

ctgcctgcct cagcctccca aagtgctggg attacagcta tgtcttctca ttttacccaa    600

gaccttctgc cagagcaggg catacaagat gcattcccaa aaagaatact gagaggatat    660

ggaaattgtg gccttgataa tttatattta aggaaagact gggaaagttt agatgagtgt    720

aagttgcaaa aagattataa tggacttaac caatgttcat caactaccca tagcaaaatc    780

tttcaatata ataaatatgt taaaatcttt gataactttt caaatttaca tagacgtaat    840

ataagtaata ctggagagaa acctttcaaa tgtcaagaat gtggcaaatc ctttcaaatg    900

ctctcattcc taactgaaca tcagaaaatt cacactggaa aaaaattcca aaaatgtgga    960

gaatgtggca aaacctttat ccagtgctca cactttactg aacctgagaa cattgacact   1020

ggagagaaac cttacaagtg tcaagaatgt aacaacgtca ttaaaacttg ctcagtcctt   1080

actaaaaata gaatttatgc cggaggggaa cattacagat gtgaagaatt tggcaaagta   1140

tttaaccagt gctcccacct tactgaacat gagcatggta ctgaggaaaa accctgcaaa   1200

tatgaagagt gcagcagtgt ctttatctct tgctcaagcc tttctaatca acagatgatt   1260

cttgctggag agaagctctc caaatgtgaa acatggtaca aaggttttaa ccacagccca   1320

aatccttcca aacaccagag aaatgagatt ggagggaaac ctttcaaatg tgaggaatgt   1380

gacagcatct tcaagtggtt ctcagacctt actaaacata agagaattca cactggtgag   1440

aaaccataca aatgtgacga atgtgggaaa gcctatacac agtcctcaca cctcagtgaa   1500

cacaggagga ttcacaccgg agagaaaccc taccaatgtg aagaatgtgg gaaggtcttc   1560

agaacttgct caagcctttc taaccataag agaactcatt ctgaagaaaa accctacacg   1620

tgtgaagaat gtggcaacat ctttaagcag ttatcagacc tcactaagca taagaaaacc   1680

catactggag agaagcccta caaatgtgac gaatgtggaa aaaactttac ccagtcctcc   1740

aaccttattg tacataagag aattcatact ggagagaaac cctacaagtg tgaagaatgt   1800

ggcagagtct tcatgtggtt ctcagacatt accaaacata agaaaaccca tactggagag   1860

aaaccctaca aatgtgacga atgtggaaaa aactttaccc agtcctcaaa ccttattgta   1920

cataagagaa ttcatactgg agagaaaccc tacaagtgtg aaaagtgtgg caaagccttc   1980

acccagttct cacacctgac tgtacatgaa agcattcata cttgagaaaa aaataaacaa   2040

atataaaaat aggcaaagcc gttagtatct gctcgcatcc cactttacat cagagttcag   2100

acttaataaa gttatcataa atgtaattac tattgaaaga cctttcatga aatataagtc   2160

tccagagcac acaagagtat ttcttctgaa aaaaatgtta caattatact agatggaaga   2220

cttgcatcag ttgcttaaac tttcagaaaa tttgtagaga aacccaacaa atctcataaa   2280

tgtggaataa catttgttca aaaatgatag cttagaaaac actagagttc atactaaaag   2340

atattttgca aatacactaa atgggaaaaa taagcaagga cacgttcaga aatgacactg   2400

aatccctgtg ttgagtctac agagacatct agacttaaaa tagatcattt atatttaagt   2460

ttaaaaggag gatgagactg agtttttgta gagttataat tacattcaaa atatactttt   2520

ttgcattgaa aaaatgttaa atttttgaaa agcgaatatt gatgtcattc tattctcaaa   2580

tcagt                                                               2585


<210>  2703
<211>  592
<212>  PRT
<213>  Homo sapiens

<400>  2703


Met Ala Gly Ala Gln Thr Leu Leu Thr Phe Arg Asp Val Ala Ile Glu 
1               5                   10                  15      


Phe Ser Leu Glu Glu Trp Lys Cys Leu Asp Leu Ala Gln Gln Asn Leu 
            20                  25                  30          


Tyr Arg Asp Val Met Leu Glu Asn Tyr Arg Asn Leu Phe Ser Val Gly 
        35                  40                  45              


Leu Thr Val Cys Lys Pro Gly Leu Ile Thr Cys Leu Glu Gln Arg Lys 
    50                  55                  60                  


Glu Pro Trp Asn Val Lys Arg Gln Glu Ala Ala Asp Gly His Pro Glu 
65                  70                  75                  80  


Met Gly Phe His His Ala Thr Gln Ala Cys Leu Glu Leu Leu Gly Ser 
                85                  90                  95      


Ser Asp Leu Pro Ala Ser Ala Ser Gln Ser Ala Gly Ile Thr Ala Met 
            100                 105                 110         


Ser Ser His Phe Thr Gln Asp Leu Leu Pro Glu Gln Gly Ile Gln Asp 
        115                 120                 125             


Ala Phe Pro Lys Arg Ile Leu Arg Gly Tyr Gly Asn Cys Gly Leu Asp 
    130                 135                 140                 


Asn Leu Tyr Leu Arg Lys Asp Trp Glu Ser Leu Asp Glu Cys Lys Leu 
145                 150                 155                 160 


Gln Lys Asp Tyr Asn Gly Leu Asn Gln Cys Ser Ser Thr Thr His Ser 
                165                 170                 175     


Lys Ile Phe Gln Tyr Asn Lys Tyr Val Lys Ile Phe Asp Asn Phe Ser 
            180                 185                 190         


Asn Leu His Arg Arg Asn Ile Ser Asn Thr Gly Glu Lys Pro Phe Lys 
        195                 200                 205             


Cys Gln Glu Cys Gly Lys Ser Phe Gln Met Leu Ser Phe Leu Thr Glu 
    210                 215                 220                 


His Gln Lys Ile His Thr Gly Lys Lys Phe Gln Lys Cys Gly Glu Cys 
225                 230                 235                 240 


Gly Lys Thr Phe Ile Gln Cys Ser His Phe Thr Glu Pro Glu Asn Ile 
                245                 250                 255     


Asp Thr Gly Glu Lys Pro Tyr Lys Cys Gln Glu Cys Asn Asn Val Ile 
            260                 265                 270         


Lys Thr Cys Ser Val Leu Thr Lys Asn Arg Ile Tyr Ala Gly Gly Glu 
        275                 280                 285             


His Tyr Arg Cys Glu Glu Phe Gly Lys Val Phe Asn Gln Cys Ser His 
    290                 295                 300                 


Leu Thr Glu His Glu His Gly Thr Glu Glu Lys Pro Cys Lys Tyr Glu 
305                 310                 315                 320 


Glu Cys Ser Ser Val Phe Ile Ser Cys Ser Ser Leu Ser Asn Gln Gln 
                325                 330                 335     


Met Ile Leu Ala Gly Glu Lys Leu Ser Lys Cys Glu Thr Trp Tyr Lys 
            340                 345                 350         


Gly Phe Asn His Ser Pro Asn Pro Ser Lys His Gln Arg Asn Glu Ile 
        355                 360                 365             


Gly Gly Lys Pro Phe Lys Cys Glu Glu Cys Asp Ser Ile Phe Lys Trp 
    370                 375                 380                 


Phe Ser Asp Leu Thr Lys His Lys Arg Ile His Thr Gly Glu Lys Pro 
385                 390                 395                 400 


Tyr Lys Cys Asp Glu Cys Gly Lys Ala Tyr Thr Gln Ser Ser His Leu 
                405                 410                 415     


Ser Glu His Arg Arg Ile His Thr Gly Glu Lys Pro Tyr Gln Cys Glu 
            420                 425                 430         


Glu Cys Gly Lys Val Phe Arg Thr Cys Ser Ser Leu Ser Asn His Lys 
        435                 440                 445             


Arg Thr His Ser Glu Glu Lys Pro Tyr Thr Cys Glu Glu Cys Gly Asn 
    450                 455                 460                 


Ile Phe Lys Gln Leu Ser Asp Leu Thr Lys His Lys Lys Thr His Thr 
465                 470                 475                 480 


Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly Lys Asn Phe Thr Gln 
                485                 490                 495     


Ser Ser Asn Leu Ile Val His Lys Arg Ile His Thr Gly Glu Lys Pro 
            500                 505                 510         


Tyr Lys Cys Glu Glu Cys Gly Arg Val Phe Met Trp Phe Ser Asp Ile 
        515                 520                 525             


Thr Lys His Lys Lys Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Asp 
    530                 535                 540                 


Glu Cys Gly Lys Asn Phe Thr Gln Ser Ser Asn Leu Ile Val His Lys 
545                 550                 555                 560 


Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Lys Cys Gly Lys 
                565                 570                 575     


Ala Phe Thr Gln Phe Ser His Leu Thr Val His Glu Ser Ile His Thr 
            580                 585                 590         

<210>  2704
<211>  2608
<212>  DNA
<213>  Homo sapiens

<400>  2704
aatcaggcac atgtctggag aggagaggac ggcttccggg atctagcggg gcctttgtcc     60

cgacagagct ccacttcctg tccccgcggc tctgtgtccc ctgctagccg taggtcgtgt    120

gacccgcagg caccgggaga tccagaagtg aaacgccagg ctctctggag gccaggagat    180

ggcacagaca ccttaccaga atgtctttgg tttgaggttc cactttggaa acttgacagg    240

gtgatttgct ctcagccacc ctctggactt tttcctcagt ttcagtattg tccagggata    300

acacaggatg cccaccatgg ccatgtctgc tggagcatct agtgaatttc aggccctggg    360

ttatttctca gaggacagcc tgaggtatga agtgtggcct ctccagggag cagctggatg    420

ccctgggctg agagaaatct cctggtctac tcttcctcta aagaggtgtg atttgtccag    480

agaatctttc ctaagaggaa atcccagaga agcaggagaa agagaaagaa atggctggtg    540

ctcagactct gttgacgttc agggatgtgg ccatagaatt ctccctggag gagtggaaat    600

gcctggacct cgctcagcag aatttgtaca gggatgtgat gttggagaac tacagaaact    660

tgttctccgt tggtctcact gtctgtaagc caggcctgat cacctgcctg gagcaacgaa    720

aagagccctg gaatgtgaag agacaggagg cagcagacgg acatccagct atgtcttctc    780

attttaccca agaccttctg ccagagcagg gcatacaaga tgcattccca aaaagaatac    840

tgagaggata tggaaattgt ggccttgata atttatattt aaggaaagac tgggaaagtt    900

tagatgagtg taagttgcaa aaagattata atggacttaa ccaatgttca tcaactaccc    960

atagcaaaat ctttcaatat aataaatatg ttaaaatctt tgataacttt tcaaatttac   1020

atagacgtaa tataagtaat actggagaga aacctttcaa atgtcaagaa tgtggcaaat   1080

cctttcaaat gctctcattc ctaactgaac atcagaaaat tcacactgga aaaaaattcc   1140

aaaaatgtgg agaatgtggc aaaaccttta tccagtgctc acactttact gaacctgaga   1200

acattgacac tggagagaaa ccttacaagt gtcaagaatg taacaacgtc attaaaactt   1260

gctcagtcct tactaaaaat agaatttatg ccggagggga acattacaga tgtgaagaat   1320

ttggcaaagt atttaaccag tgctcccacc ttactgaaca tgagcatggt actgaggaaa   1380

aacctttcaa atgtgaggaa tgtgacagca tcttcaagtg gttctcagac cttactaaac   1440

ataagagaat tcacactggt gagaaaccat acaaatgtga cgaatgtggg aaagcctata   1500

cacagtcctc acacctcagt gaacacagga ggattcacac cggagagaaa ccctaccaat   1560

gtgaagaatg tgggaaggtc ttcagaactt gctcaagcct ttctaaccat aagagaactc   1620

attctgaaga aaaaccctac acgtgtgaag aatgtggcaa catctttaag cagttatcag   1680

acctcactaa gcataagaaa acccatactg gagagaagcc ctacaaatgt gacgaatgtg   1740

gaaaaaactt tacccagtcc tccaacctta ttgtacataa gagaattcat actggagaga   1800

aaccctacaa gtgtgaagaa tgtggcagag tcttcatgtg gttctcagac attaccaaac   1860

ataagaaaac ccatactgga gagaaaccct acaaatgtga cgaatgtgga aaaaacttta   1920

cccagtcctc aaaccttatt gtacataaga gaattcatac tggagagaaa ccctacaagt   1980

gtgaaaagtg tggcaaagcc ttcacccagt tctcacacct gactgtacat gaaagcattc   2040

atacttgaga aaaaaataaa caaatataaa aataggcaaa gccgttagta tctgctcgca   2100

tcccacttta catcagagtt cagacttaat aaagttatca taaatgtaat tactattgaa   2160

agacctttca tgaaatataa gtctccagag cacacaagag tatttcttct gaaaaaaatg   2220

ttacaattat actagatgga agacttgcat cagttgctta aactttcaga aaatttgtag   2280

agaaacccaa caaatctcat aaatgtggaa taacatttgt tcaaaaatga tagcttagaa   2340

aacactagag ttcatactaa aagatatttt gcaaatacac taaatgggaa aaataagcaa   2400

ggacacgttc agaaatgaca ctgaatccct gtgttgagtc tacagagaca tctagactta   2460

aaatagatca tttatattta agtttaaaag gaggatgaga ctgagttttt gtagagttat   2520

aattacattc aaaatatact tttttgcatt gaaaaaatgt taaatttttg aaaagcgaat   2580

attgatgtca ttctattctc aaatcagt                                      2608


<210>  2705
<211>  505
<212>  PRT
<213>  Homo sapiens

<400>  2705


Met Ala Gly Ala Gln Thr Leu Leu Thr Phe Arg Asp Val Ala Ile Glu 
1               5                   10                  15      


Phe Ser Leu Glu Glu Trp Lys Cys Leu Asp Leu Ala Gln Gln Asn Leu 
            20                  25                  30          


Tyr Arg Asp Val Met Leu Glu Asn Tyr Arg Asn Leu Phe Ser Val Gly 
        35                  40                  45              


Leu Thr Val Cys Lys Pro Gly Leu Ile Thr Cys Leu Glu Gln Arg Lys 
    50                  55                  60                  


Glu Pro Trp Asn Val Lys Arg Gln Glu Ala Ala Asp Gly His Pro Ala 
65                  70                  75                  80  


Met Ser Ser His Phe Thr Gln Asp Leu Leu Pro Glu Gln Gly Ile Gln 
                85                  90                  95      


Asp Ala Phe Pro Lys Arg Ile Leu Arg Gly Tyr Gly Asn Cys Gly Leu 
            100                 105                 110         


Asp Asn Leu Tyr Leu Arg Lys Asp Trp Glu Ser Leu Asp Glu Cys Lys 
        115                 120                 125             


Leu Gln Lys Asp Tyr Asn Gly Leu Asn Gln Cys Ser Ser Thr Thr His 
    130                 135                 140                 


Ser Lys Ile Phe Gln Tyr Asn Lys Tyr Val Lys Ile Phe Asp Asn Phe 
145                 150                 155                 160 


Ser Asn Leu His Arg Arg Asn Ile Ser Asn Thr Gly Glu Lys Pro Phe 
                165                 170                 175     


Lys Cys Gln Glu Cys Gly Lys Ser Phe Gln Met Leu Ser Phe Leu Thr 
            180                 185                 190         


Glu His Gln Lys Ile His Thr Gly Lys Lys Phe Gln Lys Cys Gly Glu 
        195                 200                 205             


Cys Gly Lys Thr Phe Ile Gln Cys Ser His Phe Thr Glu Pro Glu Asn 
    210                 215                 220                 


Ile Asp Thr Gly Glu Lys Pro Tyr Lys Cys Gln Glu Cys Asn Asn Val 
225                 230                 235                 240 


Ile Lys Thr Cys Ser Val Leu Thr Lys Asn Arg Ile Tyr Ala Gly Gly 
                245                 250                 255     


Glu His Tyr Arg Cys Glu Glu Phe Gly Lys Val Phe Asn Gln Cys Ser 
            260                 265                 270         


His Leu Thr Glu His Glu His Gly Thr Glu Glu Lys Pro Phe Lys Cys 
        275                 280                 285             


Glu Glu Cys Asp Ser Ile Phe Lys Trp Phe Ser Asp Leu Thr Lys His 
    290                 295                 300                 


Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly 
305                 310                 315                 320 


Lys Ala Tyr Thr Gln Ser Ser His Leu Ser Glu His Arg Arg Ile His 
                325                 330                 335     


Thr Gly Glu Lys Pro Tyr Gln Cys Glu Glu Cys Gly Lys Val Phe Arg 
            340                 345                 350         


Thr Cys Ser Ser Leu Ser Asn His Lys Arg Thr His Ser Glu Glu Lys 
        355                 360                 365             


Pro Tyr Thr Cys Glu Glu Cys Gly Asn Ile Phe Lys Gln Leu Ser Asp 
    370                 375                 380                 


Leu Thr Lys His Lys Lys Thr His Thr Gly Glu Lys Pro Tyr Lys Cys 
385                 390                 395                 400 


Asp Glu Cys Gly Lys Asn Phe Thr Gln Ser Ser Asn Leu Ile Val His 
                405                 410                 415     


Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly 
            420                 425                 430         


Arg Val Phe Met Trp Phe Ser Asp Ile Thr Lys His Lys Lys Thr His 
        435                 440                 445             


Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly Lys Asn Phe Thr 
    450                 455                 460                 


Gln Ser Ser Asn Leu Ile Val His Lys Arg Ile His Thr Gly Glu Lys 
465                 470                 475                 480 


Pro Tyr Lys Cys Glu Lys Cys Gly Lys Ala Phe Thr Gln Phe Ser His 
                485                 490                 495     


Leu Thr Val His Glu Ser Ile His Thr 
            500                 505 

<210>  2706
<211>  2549
<212>  DNA
<213>  Homo sapiens

<400>  2706
aatcaggcac atgtctggag aggagaggac ggcttccggg atctagcggg gcctttgtcc     60

cgacagagct ccacttcctg tccccgcggc tctgtgtccc ctgctagccg taggtcgtgt    120

gacccgcagg caccgggaga tccagaagtg aaacgccagg ctctctggag gccaggagat    180

ggtgtgattt gtccagagaa tctttcctaa gaggaaatcc cagagaagca ggagaaagag    240

aaagaaatgg ctggtgctca gactctgttg acgttcaggg atgtggccat agaattctcc    300

ctggaggagt ggaaatgcct ggacctcgct cagcagaatt tgtacaggga tgtgatgttg    360

gagaactaca gaaacttgtt ctccgttggt ctcactgtct gtaagccagg cctgatcacc    420

tgcctggagc aacgaaaaga gccctggaat gtgaagagac aggaggcagc agacggacat    480

ccaggtattt tctttgtggt taccatggaa attatataaa acatcttaaa gttacaacaa    540

gctatgtctt ctcattttac ccaagacctt ctgccagagc agggcataca agatgcattc    600

ccaaaaagaa tactgagagg atatggaaat tgtggccttg ataatttata tttaaggaaa    660

gactgggaaa gtttagatga gtgtaagttg caaaaagatt ataatggact taaccaatgt    720

tcatcaacta cccatagcaa aatctttcaa tataataaat atgttaaaat ctttgataac    780

ttttcaaatt tacatagacg taatataagt aatactggag agaaaccttt caaatgtcaa    840

gaatgtggca aatcctttca aatgctctca ttcctaactg aacatcagaa aattcacact    900

ggaaaaaaat tccaaaaatg tggagaatgt ggcaaaacct ttatccagtg ctcacacttt    960

actgaacctg agaacattga cactggagag aaaccttaca agtgtcaaga atgtaacaac   1020

gtcattaaaa cttgctcagt ccttactaaa aatagaattt atgccggagg ggaacattac   1080

agatgtgaag aatttggcaa agtatttaac cagtgctccc accttactga acatgagcat   1140

ggtactgagg aaaaaccctg caaatatgaa gagtgcagca gtgtctttat ctcttgctca   1200

agcctttcta atcaacagat gattcttgct ggagagaagc tctccaaatg tgaaacatgg   1260

tacaaaggtt ttaaccacag cccaaatcct tccaaacacc agagaaatga gattggaggg   1320

aaacctttca aatgtgagga atgtgacagc atcttcaagt ggttctcaga ccttactaaa   1380

cataagagaa ttcacactgg tgagaaacca tacaaatgtg acgaatgtgg gaaagcctat   1440

acacagtcct cacacctcag tgaacacagg aggattcaca ccggagagaa accctaccaa   1500

tgtgaagaat gtgggaaggt cttcagaact tgctcaagcc tttctaacca taagagaact   1560

cattctgaag aaaaacccta cacgtgtgaa gaatgtggca acatctttaa gcagttatca   1620

gacctcacta agcataagaa aacccatact ggagagaagc cctacaaatg tgacgaatgt   1680

ggaaaaaact ttacccagtc ctccaacctt attgtacata agagaattca tactggagag   1740

aaaccctaca agtgtgaaga atgtggcaga gtcttcatgt ggttctcaga cattaccaaa   1800

cataagaaaa cccatactgg agagaaaccc tacaaatgtg acgaatgtgg aaaaaacttt   1860

acccagtcct caaaccttat tgtacataag agaattcata ctggagagaa accctacaag   1920

tgtgaaaagt gtggcaaagc cttcacccag ttctcacacc tgactgtaca tgaaagcatt   1980

catacttgag aaaaaaataa acaaatataa aaataggcaa agccgttagt atctgctcgc   2040

atcccacttt acatcagagt tcagacttaa taaagttatc ataaatgtaa ttactattga   2100

aagacctttc atgaaatata agtctccaga gcacacaaga gtatttcttc tgaaaaaaat   2160

gttacaatta tactagatgg aagacttgca tcagttgctt aaactttcag aaaatttgta   2220

gagaaaccca acaaatctca taaatgtgga ataacatttg ttcaaaaatg atagcttaga   2280

aaacactaga gttcatacta aaagatattt tgcaaataca ctaaatggga aaaataagca   2340

aggacacgtt cagaaatgac actgaatccc tgtgttgagt ctacagagac atctagactt   2400

aaaatagatc atttatattt aagtttaaaa ggaggatgag actgagtttt tgtagagtta   2460

taattacatt caaaatatac ttttttgcat tgaaaaaatg ttaaattttt gaaaagcgaa   2520

tattgatgtc attctattct caaatcagt                                     2549


<210>  2707
<211>  90
<212>  PRT
<213>  Homo sapiens

<400>  2707


Met Ala Gly Ala Gln Thr Leu Leu Thr Phe Arg Asp Val Ala Ile Glu 
1               5                   10                  15      


Phe Ser Leu Glu Glu Trp Lys Cys Leu Asp Leu Ala Gln Gln Asn Leu 
            20                  25                  30          


Tyr Arg Asp Val Met Leu Glu Asn Tyr Arg Asn Leu Phe Ser Val Gly 
        35                  40                  45              


Leu Thr Val Cys Lys Pro Gly Leu Ile Thr Cys Leu Glu Gln Arg Lys 
    50                  55                  60                  


Glu Pro Trp Asn Val Lys Arg Gln Glu Ala Ala Asp Gly His Pro Gly 
65                  70                  75                  80  


Ile Phe Phe Val Val Thr Met Glu Ile Ile 
                85                  90  

<210>  2708
<211>  2992
<212>  DNA
<213>  Homo sapiens

<400>  2708
aatcaggcac atgtctggag aggagaggac ggcttccggg atctagcggg gcctttgtcc     60

cgacagagct ccacttcctg tccccgcggc tctgtgtccc ctgctagccg taggtcgtgt    120

gacccgcagg caccgggaga tccagaagtg aaacgccagg ctctctggag gccaggagat    180

ggcacagaca ccttaccaga atgtctttgg tttgaggttc cactttggaa acttgacagg    240

gtgatttgct ctcagccacc ctctggactt tttcctcagt ttcagtattg tccagggata    300

acacaggatg cccaccatgg ccatgtctgc tggagcatct agtgaatttc aggccctggg    360

ttatttctca gaggacagcc tgaggtatga agtgtggcct ctccagggag cagctggatg    420

ccctgggctg agagaaatct cctggtctac tcttcctcta aagaggtgtg atttgtccag    480

agaatctttc ctaagaggaa atcccagaga agcaggagaa agagaaagaa atggctggtg    540

ctcagactct gttgacgttc agggatgtgg ccatagaatt ctccctggag gagtggaaat    600

gcctggacct cgctcagcag aatttgtaca gggatgtgat gttggagaac tacagaaact    660

tgttctccgt tggtctcact gtctgtaagc caggcctgat cacctgcctg gagcaacgaa    720

aagagccctg gaatgtgaag agacaggagg cagcagacgg acatccagag atgggatttc    780

accatgctac tcaggcttgt cttgaactcc tgggctcaag cgatctgcct gcctcagcct    840

cccaaagtgc tgggattaca ggtgtgaacc accgtgccca gccaggcctc aatgtttctg    900

tggacaaatt cactgcactg tgctcacctg gggtgctgca aactgtgaaa tggtttttag    960

agttcagatg catcttctca ctagctatgt cttctcattt tacccaagac cttctgccag   1020

agcagggcat acaagatgca ttcccaaaaa gaatactgag aggatatgga aattgtggcc   1080

ttgataattt atatttaagg aaagactggg aaagtttaga tgagtgtaag ttgcaaaaag   1140

attataatgg acttaaccaa tgttcatcaa ctacccatag caaaatcttt caatataata   1200

aatatgttaa aatctttgat aacttttcaa atttacatag acgtaatata agtaatactg   1260

gagagaaacc tttcaaatgt caagaatgtg gcaaatcctt tcaaatgctc tcattcctaa   1320

ctgaacatca gaaaattcac actggaaaaa aattccaaaa atgtggagaa tgtggcaaaa   1380

cctttatcca gtgctcacac tttactgaac ctgagaacat tgacactgga gagaaacctt   1440

acaagtgtca agaatgtaac aacgtcatta aaacttgctc agtccttact aaaaatagaa   1500

tttatgccgg aggggaacat tacagatgtg aagaatttgg caaagtattt aaccagtgct   1560

cccaccttac tgaacatgag catggtactg aggaaaaacc ctgcaaatat gaagagtgca   1620

gcagtgtctt tatctcttgc tcaagccttt ctaatcaaca gatgattctt gctggagaga   1680

agctctccaa atgtgaaaca tggtacaaag gttttaacca cagcccaaat ccttccaaac   1740

accagagaaa tgagattgga gggaaacctt tcaaatgtga ggaatgtgac agcatcttca   1800

agtggttctc agaccttact aaacataaga gaattcacac tggtgagaaa ccatacaaat   1860

gtgacgaatg tgggaaagcc tatacacagt cctcacacct cagtgaacac aggaggattc   1920

acaccggaga gaaaccctac caatgtgaag aatgtgggaa ggtcttcaga acttgctcaa   1980

gcctttctaa ccataagaga actcattctg aagaaaaacc ctacacgtgt gaagaatgtg   2040

gcaacatctt taagcagtta tcagacctca ctaagcataa gaaaacccat actggagaga   2100

agccctacaa atgtgacgaa tgtggaaaaa actttaccca gtcctccaac cttattgtac   2160

ataagagaat tcatactgga gagaaaccct acaagtgtga agaatgtggc agagtcttca   2220

tgtggttctc agacattacc aaacataaga aaacccatac tggagagaaa ccctacaaat   2280

gtgacgaatg tggaaaaaac tttacccagt cctcaaacct tattgtacat aagagaattc   2340

atactggaga gaaaccctac aagtgtgaaa agtgtggcaa agccttcacc cagttctcac   2400

acctgactgt acatgaaagc attcatactt gagaaaaaaa taaacaaata taaaaatagg   2460

caaagccgtt agtatctgct cgcatcccac tttacatcag agttcagact taataaagtt   2520

atcataaatg taattactat tgaaagacct ttcatgaaat ataagtctcc agagcacaca   2580

agagtatttc ttctgaaaaa aatgttacaa ttatactaga tggaagactt gcatcagttg   2640

cttaaacttt cagaaaattt gtagagaaac ccaacaaatc tcataaatgt ggaataacat   2700

ttgttcaaaa atgatagctt agaaaacact agagttcata ctaaaagata ttttgcaaat   2760

acactaaatg ggaaaaataa gcaaggacac gttcagaaat gacactgaat ccctgtgttg   2820

agtctacaga gacatctaga cttaaaatag atcatttata tttaagttta aaaggaggat   2880

gagactgagt ttttgtagag ttataattac attcaaaata tacttttttg cattgaaaaa   2940

atgttaaatt tttgaaaagc gaatattgat gtcattctat tctcaaatca gt           2992


<210>  2709
<211>  633
<212>  PRT
<213>  Homo sapiens

<400>  2709


Met Ala Gly Ala Gln Thr Leu Leu Thr Phe Arg Asp Val Ala Ile Glu 
1               5                   10                  15      


Phe Ser Leu Glu Glu Trp Lys Cys Leu Asp Leu Ala Gln Gln Asn Leu 
            20                  25                  30          


Tyr Arg Asp Val Met Leu Glu Asn Tyr Arg Asn Leu Phe Ser Val Gly 
        35                  40                  45              


Leu Thr Val Cys Lys Pro Gly Leu Ile Thr Cys Leu Glu Gln Arg Lys 
    50                  55                  60                  


Glu Pro Trp Asn Val Lys Arg Gln Glu Ala Ala Asp Gly His Pro Glu 
65                  70                  75                  80  


Met Gly Phe His His Ala Thr Gln Ala Cys Leu Glu Leu Leu Gly Ser 
                85                  90                  95      


Ser Asp Leu Pro Ala Ser Ala Ser Gln Ser Ala Gly Ile Thr Gly Val 
            100                 105                 110         


Asn His Arg Ala Gln Pro Gly Leu Asn Val Ser Val Asp Lys Phe Thr 
        115                 120                 125             


Ala Leu Cys Ser Pro Gly Val Leu Gln Thr Val Lys Trp Phe Leu Glu 
    130                 135                 140                 


Phe Arg Cys Ile Phe Ser Leu Ala Met Ser Ser His Phe Thr Gln Asp 
145                 150                 155                 160 


Leu Leu Pro Glu Gln Gly Ile Gln Asp Ala Phe Pro Lys Arg Ile Leu 
                165                 170                 175     


Arg Gly Tyr Gly Asn Cys Gly Leu Asp Asn Leu Tyr Leu Arg Lys Asp 
            180                 185                 190         


Trp Glu Ser Leu Asp Glu Cys Lys Leu Gln Lys Asp Tyr Asn Gly Leu 
        195                 200                 205             


Asn Gln Cys Ser Ser Thr Thr His Ser Lys Ile Phe Gln Tyr Asn Lys 
    210                 215                 220                 


Tyr Val Lys Ile Phe Asp Asn Phe Ser Asn Leu His Arg Arg Asn Ile 
225                 230                 235                 240 


Ser Asn Thr Gly Glu Lys Pro Phe Lys Cys Gln Glu Cys Gly Lys Ser 
                245                 250                 255     


Phe Gln Met Leu Ser Phe Leu Thr Glu His Gln Lys Ile His Thr Gly 
            260                 265                 270         


Lys Lys Phe Gln Lys Cys Gly Glu Cys Gly Lys Thr Phe Ile Gln Cys 
        275                 280                 285             


Ser His Phe Thr Glu Pro Glu Asn Ile Asp Thr Gly Glu Lys Pro Tyr 
    290                 295                 300                 


Lys Cys Gln Glu Cys Asn Asn Val Ile Lys Thr Cys Ser Val Leu Thr 
305                 310                 315                 320 


Lys Asn Arg Ile Tyr Ala Gly Gly Glu His Tyr Arg Cys Glu Glu Phe 
                325                 330                 335     


Gly Lys Val Phe Asn Gln Cys Ser His Leu Thr Glu His Glu His Gly 
            340                 345                 350         


Thr Glu Glu Lys Pro Cys Lys Tyr Glu Glu Cys Ser Ser Val Phe Ile 
        355                 360                 365             


Ser Cys Ser Ser Leu Ser Asn Gln Gln Met Ile Leu Ala Gly Glu Lys 
    370                 375                 380                 


Leu Ser Lys Cys Glu Thr Trp Tyr Lys Gly Phe Asn His Ser Pro Asn 
385                 390                 395                 400 


Pro Ser Lys His Gln Arg Asn Glu Ile Gly Gly Lys Pro Phe Lys Cys 
                405                 410                 415     


Glu Glu Cys Asp Ser Ile Phe Lys Trp Phe Ser Asp Leu Thr Lys His 
            420                 425                 430         


Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly 
        435                 440                 445             


Lys Ala Tyr Thr Gln Ser Ser His Leu Ser Glu His Arg Arg Ile His 
    450                 455                 460                 


Thr Gly Glu Lys Pro Tyr Gln Cys Glu Glu Cys Gly Lys Val Phe Arg 
465                 470                 475                 480 


Thr Cys Ser Ser Leu Ser Asn His Lys Arg Thr His Ser Glu Glu Lys 
                485                 490                 495     


Pro Tyr Thr Cys Glu Glu Cys Gly Asn Ile Phe Lys Gln Leu Ser Asp 
            500                 505                 510         


Leu Thr Lys His Lys Lys Thr His Thr Gly Glu Lys Pro Tyr Lys Cys 
        515                 520                 525             


Asp Glu Cys Gly Lys Asn Phe Thr Gln Ser Ser Asn Leu Ile Val His 
    530                 535                 540                 


Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly 
545                 550                 555                 560 


Arg Val Phe Met Trp Phe Ser Asp Ile Thr Lys His Lys Lys Thr His 
                565                 570                 575     


Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly Lys Asn Phe Thr 
            580                 585                 590         


Gln Ser Ser Asn Leu Ile Val His Lys Arg Ile His Thr Gly Glu Lys 
        595                 600                 605             


Pro Tyr Lys Cys Glu Lys Cys Gly Lys Ala Phe Thr Gln Phe Ser His 
    610                 615                 620                 


Leu Thr Val His Glu Ser Ile His Thr 
625                 630             

<210>  2710
<211>  2708
<212>  DNA
<213>  Homo sapiens

<400>  2710
aatcaggcac atgtctggag aggagaggac ggcttccggg atctagcggg gcctttgtcc     60

cgacagagct ccacttcctg tccccgcggc tctgtgtccc ctgctagccg taggtcgtgt    120

gacccgcagg caccgggaga tccagaagtg aaacgccagg ctctctggag gccaggagat    180

ggtgtgattt gtccagagaa tctttcctaa gaggaaatcc cagagaagca ggagaaagag    240

aaagaaatgg ctggtgctca gactctgttg acgttcaggg atgtggccat agaattctcc    300

ctggaggagt ggaaatgcct ggacctcgct cagcagaatt tgtacaggga tgtgatgttg    360

gagaactaca gaaacttgtt ctccgttggt ctcactgtct gtaagccagg cctgatcacc    420

tgcctggagc aacgaaaaga gccctggaat gtgaagagac aggaggcagc agacggacat    480

ccagagatgg gatttcacca tgctactcag gcttgtcttg aactcctggg ctcaagcgat    540

ctgcctgcct cagcctccca aagtgctggg attacaggtg tgaaccaccg tgcccagcca    600

ggcctcaatg tttctgtgga caaattcact gcactgtgct cacctggggt gctgcaaact    660

gtgaaatggt ttttagagtt cagatgcatc ttctcactag ctatgtcttc tcattttacc    720

caagaccttc tgccagagca gggcatacaa gatgcattcc caaaaagaat actgagagga    780

tatggaaatt gtggccttga taatttatat ttaaggaaag actgggaaag tttagatgag    840

tgtaagttgc aaaaagatta taatggactt aaccaatgtt catcaactac ccatagcaaa    900

atctttcaat ataataaata tgttaaaatc tttgataact tttcaaattt acatagacgt    960

aatataagta atactggaga gaaacctttc aaatgtcaag aatgtggcaa atcctttcaa   1020

atgctctcat tcctaactga acatcagaaa attcacactg gaaaaaaatt ccaaaaatgt   1080

ggagaatgtg gcaaaacctt tatccagtgc tcacacttta ctgaacctga gaacattgac   1140

actggagaga aaccttacaa gtgtcaagaa tgtaacaacg tcattaaaac ttgctcagtc   1200

cttactaaaa atagaattta tgccggaggg gaacattaca gatgtgaaga atttggcaaa   1260

gtatttaacc agtgctccca ccttactgaa catgagcatg gtactgagga aaaaccctgc   1320

aaatatgaag agtgcagcag tgtctttatc tcttgctcaa gcctttctaa tcaacagatg   1380

attcttgctg gagagaagct ctccaaatgt gaaacatggt acaaaggttt taaccacagc   1440

ccaaatcctt ccaaacacca gagaaatgag attggaggga aacctttcaa atgtgaggaa   1500

tgtgacagca tcttcaagtg gttctcagac cttactaaac ataagagaat tcacactggt   1560

gagaaaccat acaaatgtga cgaatgtggg aaagcctata cacagtcctc acacctcagt   1620

gaacacagga ggattcacac cggagagaaa ccctaccaat gtgaagaatg tgggaaggtc   1680

ttcagaactt gctcaagcct ttctaaccat aagagaactc attctgaaga aaaaccctac   1740

acgtgtgaag aatgtggcaa catctttaag cagttatcag acctcactaa gcataagaaa   1800

acccatactg gagagaagcc ctacaaatgt gacgaatgtg gaaaaaactt tacccagtcc   1860

tccaacctta ttgtacataa gagaattcat actggagaga aaccctacaa gtgtgaagaa   1920

tgtggcagag tcttcatgtg gttctcagac attaccaaac ataagaaaac ccatactgga   1980

gagaaaccct acaaatgtga cgaatgtgga aaaaacttta cccagtcctc aaaccttatt   2040

gtacataaga gaattcatac tggagagaaa ccctacaagt gtgaaaagtg tggcaaagcc   2100

ttcacccagt tctcacacct gactgtacat gaaagcattc atacttgaga aaaaaataaa   2160

caaatataaa aataggcaaa gccgttagta tctgctcgca tcccacttta catcagagtt   2220

cagacttaat aaagttatca taaatgtaat tactattgaa agacctttca tgaaatataa   2280

gtctccagag cacacaagag tatttcttct gaaaaaaatg ttacaattat actagatgga   2340

agacttgcat cagttgctta aactttcaga aaatttgtag agaaacccaa caaatctcat   2400

aaatgtggaa taacatttgt tcaaaaatga tagcttagaa aacactagag ttcatactaa   2460

aagatatttt gcaaatacac taaatgggaa aaataagcaa ggacacgttc agaaatgaca   2520

ctgaatccct gtgttgagtc tacagagaca tctagactta aaatagatca tttatattta   2580

agtttaaaag gaggatgaga ctgagttttt gtagagttat aattacattc aaaatatact   2640

tttttgcatt gaaaaaatgt taaatttttg aaaagcgaat attgatgtca ttctattctc   2700

aaatcagt                                                            2708


<210>  2711
<211>  633
<212>  PRT
<213>  Homo sapiens

<400>  2711


Met Ala Gly Ala Gln Thr Leu Leu Thr Phe Arg Asp Val Ala Ile Glu 
1               5                   10                  15      


Phe Ser Leu Glu Glu Trp Lys Cys Leu Asp Leu Ala Gln Gln Asn Leu 
            20                  25                  30          


Tyr Arg Asp Val Met Leu Glu Asn Tyr Arg Asn Leu Phe Ser Val Gly 
        35                  40                  45              


Leu Thr Val Cys Lys Pro Gly Leu Ile Thr Cys Leu Glu Gln Arg Lys 
    50                  55                  60                  


Glu Pro Trp Asn Val Lys Arg Gln Glu Ala Ala Asp Gly His Pro Glu 
65                  70                  75                  80  


Met Gly Phe His His Ala Thr Gln Ala Cys Leu Glu Leu Leu Gly Ser 
                85                  90                  95      


Ser Asp Leu Pro Ala Ser Ala Ser Gln Ser Ala Gly Ile Thr Gly Val 
            100                 105                 110         


Asn His Arg Ala Gln Pro Gly Leu Asn Val Ser Val Asp Lys Phe Thr 
        115                 120                 125             


Ala Leu Cys Ser Pro Gly Val Leu Gln Thr Val Lys Trp Phe Leu Glu 
    130                 135                 140                 


Phe Arg Cys Ile Phe Ser Leu Ala Met Ser Ser His Phe Thr Gln Asp 
145                 150                 155                 160 


Leu Leu Pro Glu Gln Gly Ile Gln Asp Ala Phe Pro Lys Arg Ile Leu 
                165                 170                 175     


Arg Gly Tyr Gly Asn Cys Gly Leu Asp Asn Leu Tyr Leu Arg Lys Asp 
            180                 185                 190         


Trp Glu Ser Leu Asp Glu Cys Lys Leu Gln Lys Asp Tyr Asn Gly Leu 
        195                 200                 205             


Asn Gln Cys Ser Ser Thr Thr His Ser Lys Ile Phe Gln Tyr Asn Lys 
    210                 215                 220                 


Tyr Val Lys Ile Phe Asp Asn Phe Ser Asn Leu His Arg Arg Asn Ile 
225                 230                 235                 240 


Ser Asn Thr Gly Glu Lys Pro Phe Lys Cys Gln Glu Cys Gly Lys Ser 
                245                 250                 255     


Phe Gln Met Leu Ser Phe Leu Thr Glu His Gln Lys Ile His Thr Gly 
            260                 265                 270         


Lys Lys Phe Gln Lys Cys Gly Glu Cys Gly Lys Thr Phe Ile Gln Cys 
        275                 280                 285             


Ser His Phe Thr Glu Pro Glu Asn Ile Asp Thr Gly Glu Lys Pro Tyr 
    290                 295                 300                 


Lys Cys Gln Glu Cys Asn Asn Val Ile Lys Thr Cys Ser Val Leu Thr 
305                 310                 315                 320 


Lys Asn Arg Ile Tyr Ala Gly Gly Glu His Tyr Arg Cys Glu Glu Phe 
                325                 330                 335     


Gly Lys Val Phe Asn Gln Cys Ser His Leu Thr Glu His Glu His Gly 
            340                 345                 350         


Thr Glu Glu Lys Pro Cys Lys Tyr Glu Glu Cys Ser Ser Val Phe Ile 
        355                 360                 365             


Ser Cys Ser Ser Leu Ser Asn Gln Gln Met Ile Leu Ala Gly Glu Lys 
    370                 375                 380                 


Leu Ser Lys Cys Glu Thr Trp Tyr Lys Gly Phe Asn His Ser Pro Asn 
385                 390                 395                 400 


Pro Ser Lys His Gln Arg Asn Glu Ile Gly Gly Lys Pro Phe Lys Cys 
                405                 410                 415     


Glu Glu Cys Asp Ser Ile Phe Lys Trp Phe Ser Asp Leu Thr Lys His 
            420                 425                 430         


Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly 
        435                 440                 445             


Lys Ala Tyr Thr Gln Ser Ser His Leu Ser Glu His Arg Arg Ile His 
    450                 455                 460                 


Thr Gly Glu Lys Pro Tyr Gln Cys Glu Glu Cys Gly Lys Val Phe Arg 
465                 470                 475                 480 


Thr Cys Ser Ser Leu Ser Asn His Lys Arg Thr His Ser Glu Glu Lys 
                485                 490                 495     


Pro Tyr Thr Cys Glu Glu Cys Gly Asn Ile Phe Lys Gln Leu Ser Asp 
            500                 505                 510         


Leu Thr Lys His Lys Lys Thr His Thr Gly Glu Lys Pro Tyr Lys Cys 
        515                 520                 525             


Asp Glu Cys Gly Lys Asn Phe Thr Gln Ser Ser Asn Leu Ile Val His 
    530                 535                 540                 


Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Glu Cys Gly 
545                 550                 555                 560 


Arg Val Phe Met Trp Phe Ser Asp Ile Thr Lys His Lys Lys Thr His 
                565                 570                 575     


Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly Lys Asn Phe Thr 
            580                 585                 590         


Gln Ser Ser Asn Leu Ile Val His Lys Arg Ile His Thr Gly Glu Lys 
        595                 600                 605             


Pro Tyr Lys Cys Glu Lys Cys Gly Lys Ala Phe Thr Gln Phe Ser His 
    610                 615                 620                 


Leu Thr Val His Glu Ser Ile His Thr 
625                 630             

<210>  2712
<211>  2709
<212>  DNA
<213>  Homo sapiens

<400>  2712
aatcaggcac atgtctggag aggagaggac ggcttccggg atctagcggg gcctttgtcc     60

cgacagagct ccacttcctg tccccgcggc tctgtgtccc ctgctagccg taggtcgtgt    120

gacccgcagg caccgggaga tccagaagtg aaacgccagg ctctctggag gccaggagat    180

ggtgtgattt gtccagagaa tctttcctaa gaggaaatcc cagagaagca ggagaaagag    240

aaagaaatgg ctggtgctca gactctgttg acgttcaggg atgtggccat agaattctcc    300

ctggaggagt ggaaatgcct ggacctcgct cagcagaatt tgtacaggga tgtgatgttg    360

gagaactaca gaaacttgtt ctccgttggt ctcactgtct gtaagccagg cctgatcacc    420

tgcctggagc aacgaaaaga gccctggaat gtgaagagac aggaggcagc agacggacat    480

ccaggtattt tctttgtggt taccatggaa attatataaa acatcttaaa gttacaacaa    540

ggtattttac actgagatgg gatttcacca tgctactcag gcttgtcttg aactcctggg    600

ctcaagcgat ctgcctgcct cagcctccca aagtgctggg attacaggtg tgaaccaccg    660

tgcccagcca ggcctcaatg tttctgtgga caaattcact gctatgtctt ctcattttac    720

ccaagacctt ctgccagagc agggcataca agatgcattc ccaaaaagaa tactgagagg    780

atatggaaat tgtggccttg ataatttata tttaaggaaa gactgggaaa gtttagatga    840

gtgtaagttg caaaaagatt ataatggact taaccaatgt tcatcaacta cccatagcaa    900

aatctttcaa tataataaat atgttaaaat ctttgataac ttttcaaatt tacatagacg    960

taatataagt aatactggag agaaaccttt caaatgtcaa gaatgtggca aatcctttca   1020

aatgctctca ttcctaactg aacatcagaa aattcacact ggaaaaaaat tccaaaaatg   1080

tggagaatgt ggcaaaacct ttatccagtg ctcacacttt actgaacctg agaacattga   1140

cactggagag aaaccttaca agtgtcaaga atgtaacaac gtcattaaaa cttgctcagt   1200

ccttactaaa aatagaattt atgccggagg ggaacattac agatgtgaag aatttggcaa   1260

agtatttaac cagtgctccc accttactga acatgagcat ggtactgagg aaaaaccctg   1320

caaatatgaa gagtgcagca gtgtctttat ctcttgctca agcctttcta atcaacagat   1380

gattcttgct ggagagaagc tctccaaatg tgaaacatgg tacaaaggtt ttaaccacag   1440

cccaaatcct tccaaacacc agagaaatga gattggaggg aaacctttca aatgtgagga   1500

atgtgacagc atcttcaagt ggttctcaga ccttactaaa cataagagaa ttcacactgg   1560

tgagaaacca tacaaatgtg acgaatgtgg gaaagcctat acacagtcct cacacctcag   1620

tgaacacagg aggattcaca ccggagagaa accctaccaa tgtgaagaat gtgggaaggt   1680

cttcagaact tgctcaagcc tttctaacca taagagaact cattctgaag aaaaacccta   1740

cacgtgtgaa gaatgtggca acatctttaa gcagttatca gacctcacta agcataagaa   1800

aacccatact ggagagaagc cctacaaatg tgacgaatgt ggaaaaaact ttacccagtc   1860

ctccaacctt attgtacata agagaattca tactggagag aaaccctaca agtgtgaaga   1920

atgtggcaga gtcttcatgt ggttctcaga cattaccaaa cataagaaaa cccatactgg   1980

agagaaaccc tacaaatgtg acgaatgtgg aaaaaacttt acccagtcct caaaccttat   2040

tgtacataag agaattcata ctggagagaa accctacaag tgtgaaaagt gtggcaaagc   2100

cttcacccag ttctcacacc tgactgtaca tgaaagcatt catacttgag aaaaaaataa   2160

acaaatataa aaataggcaa agccgttagt atctgctcgc atcccacttt acatcagagt   2220

tcagacttaa taaagttatc ataaatgtaa ttactattga aagacctttc atgaaatata   2280

agtctccaga gcacacaaga gtatttcttc tgaaaaaaat gttacaatta tactagatgg   2340

aagacttgca tcagttgctt aaactttcag aaaatttgta gagaaaccca acaaatctca   2400

taaatgtgga ataacatttg ttcaaaaatg atagcttaga aaacactaga gttcatacta   2460

aaagatattt tgcaaataca ctaaatggga aaaataagca aggacacgtt cagaaatgac   2520

actgaatccc tgtgttgagt ctacagagac atctagactt aaaatagatc atttatattt   2580

aagtttaaaa ggaggatgag actgagtttt tgtagagtta taattacatt caaaatatac   2640

ttttttgcat tgaaaaaatg ttaaattttt gaaaagcgaa tattgatgtc attctattct   2700

caaatcagt                                                           2709


<210>  2713
<211>  530
<212>  PRT
<213>  Homo sapiens

<400>  2713


Met Gly Phe His His Ala Thr Gln Ala Cys Leu Glu Leu Leu Gly Ser 
1               5                   10                  15      


Ser Asp Leu Pro Ala Ser Ala Ser Gln Ser Ala Gly Ile Thr Gly Val 
            20                  25                  30          


Asn His Arg Ala Gln Pro Gly Leu Asn Val Ser Val Asp Lys Phe Thr 
        35                  40                  45              


Ala Met Ser Ser His Phe Thr Gln Asp Leu Leu Pro Glu Gln Gly Ile 
    50                  55                  60                  


Gln Asp Ala Phe Pro Lys Arg Ile Leu Arg Gly Tyr Gly Asn Cys Gly 
65                  70                  75                  80  


Leu Asp Asn Leu Tyr Leu Arg Lys Asp Trp Glu Ser Leu Asp Glu Cys 
                85                  90                  95      


Lys Leu Gln Lys Asp Tyr Asn Gly Leu Asn Gln Cys Ser Ser Thr Thr 
            100                 105                 110         


His Ser Lys Ile Phe Gln Tyr Asn Lys Tyr Val Lys Ile Phe Asp Asn 
        115                 120                 125             


Phe Ser Asn Leu His Arg Arg Asn Ile Ser Asn Thr Gly Glu Lys Pro 
    130                 135                 140                 


Phe Lys Cys Gln Glu Cys Gly Lys Ser Phe Gln Met Leu Ser Phe Leu 
145                 150                 155                 160 


Thr Glu His Gln Lys Ile His Thr Gly Lys Lys Phe Gln Lys Cys Gly 
                165                 170                 175     


Glu Cys Gly Lys Thr Phe Ile Gln Cys Ser His Phe Thr Glu Pro Glu 
            180                 185                 190         


Asn Ile Asp Thr Gly Glu Lys Pro Tyr Lys Cys Gln Glu Cys Asn Asn 
        195                 200                 205             


Val Ile Lys Thr Cys Ser Val Leu Thr Lys Asn Arg Ile Tyr Ala Gly 
    210                 215                 220                 


Gly Glu His Tyr Arg Cys Glu Glu Phe Gly Lys Val Phe Asn Gln Cys 
225                 230                 235                 240 


Ser His Leu Thr Glu His Glu His Gly Thr Glu Glu Lys Pro Cys Lys 
                245                 250                 255     


Tyr Glu Glu Cys Ser Ser Val Phe Ile Ser Cys Ser Ser Leu Ser Asn 
            260                 265                 270         


Gln Gln Met Ile Leu Ala Gly Glu Lys Leu Ser Lys Cys Glu Thr Trp 
        275                 280                 285             


Tyr Lys Gly Phe Asn His Ser Pro Asn Pro Ser Lys His Gln Arg Asn 
    290                 295                 300                 


Glu Ile Gly Gly Lys Pro Phe Lys Cys Glu Glu Cys Asp Ser Ile Phe 
305                 310                 315                 320 


Lys Trp Phe Ser Asp Leu Thr Lys His Lys Arg Ile His Thr Gly Glu 
                325                 330                 335     


Lys Pro Tyr Lys Cys Asp Glu Cys Gly Lys Ala Tyr Thr Gln Ser Ser 
            340                 345                 350         


His Leu Ser Glu His Arg Arg Ile His Thr Gly Glu Lys Pro Tyr Gln 
        355                 360                 365             


Cys Glu Glu Cys Gly Lys Val Phe Arg Thr Cys Ser Ser Leu Ser Asn 
    370                 375                 380                 


His Lys Arg Thr His Ser Glu Glu Lys Pro Tyr Thr Cys Glu Glu Cys 
385                 390                 395                 400 


Gly Asn Ile Phe Lys Gln Leu Ser Asp Leu Thr Lys His Lys Lys Thr 
                405                 410                 415     


His Thr Gly Glu Lys Pro Tyr Lys Cys Asp Glu Cys Gly Lys Asn Phe 
            420                 425                 430         


Thr Gln Ser Ser Asn Leu Ile Val His Lys Arg Ile His Thr Gly Glu 
        435                 440                 445             


Lys Pro Tyr Lys Cys Glu Glu Cys Gly Arg Val Phe Met Trp Phe Ser 
    450                 455                 460                 


Asp Ile Thr Lys His Lys Lys Thr His Thr Gly Glu Lys Pro Tyr Lys 
465                 470                 475                 480 


Cys Asp Glu Cys Gly Lys Asn Phe Thr Gln Ser Ser Asn Leu Ile Val 
                485                 490                 495     


His Lys Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Lys Cys 
            500                 505                 510         


Gly Lys Ala Phe Thr Gln Phe Ser His Leu Thr Val His Glu Ser Ile 
        515                 520                 525             


His Thr 
    530 

<210>  2714
<211>  783
<212>  DNA
<213>  Homo sapiens

<400>  2714
atcaggcaca tgtctggaga ggagaggacg gcttccggga tctagcgggg cctttgtccc     60

gacagagctc cacttcctgt ccccgcggct ctgtgtcccc tgctagccgt aggtcgtgtg    120

acccgcaggc accgggagat ccagaagtga aacgccaggc tctctggagg ccaggagatg    180

actctgttga cgttcaggga tgtggccata gaattctccc tggaggagtg gaaatgcctg    240

gacctcgctc agcagaattt gtacagggat gtgatgttgg agaactacag aaacttgttc    300

tccgttggtc tcactgtctg taagccaggc ctgatcacct gcctggagca acgaaaagag    360

ccctggaatg tgaagagaca ggaggcagca gacggacatc cagagatggg atttcaccat    420

gctactcagg cttgtcttga actcctgggc tcaagcgatc tgcctgcctc agcctcccaa    480

agtgctggga ttacaggtgt gaaccaccgt gcccagccag gcctcaatgt ttctgtggac    540

aaattcactg ctatgtcttc tcattttacc caagaccttc tgccagagca gggcatacaa    600

gatgcattcc caaaaagaat actgagagga tatggaaatt gtggccttga taatttatat    660

ttaaggaaag actgggaaag tttagatgag tgtaagttgc aaaaagatta taatggactt    720

aaccaatgtt catcaactac ccatagcaaa atctttcaat ataataaata tgttaaaatc    780

ttt                                                                  783


<210>  2715
<211>  201
<212>  PRT
<213>  Homo sapiens

<400>  2715


Met Thr Leu Leu Thr Phe Arg Asp Val Ala Ile Glu Phe Ser Leu Glu 
1               5                   10                  15      


Glu Trp Lys Cys Leu Asp Leu Ala Gln Gln Asn Leu Tyr Arg Asp Val 
            20                  25                  30          


Met Leu Glu Asn Tyr Arg Asn Leu Phe Ser Val Gly Leu Thr Val Cys 
        35                  40                  45              


Lys Pro Gly Leu Ile Thr Cys Leu Glu Gln Arg Lys Glu Pro Trp Asn 
    50                  55                  60                  


Val Lys Arg Gln Glu Ala Ala Asp Gly His Pro Glu Met Gly Phe His 
65                  70                  75                  80  


His Ala Thr Gln Ala Cys Leu Glu Leu Leu Gly Ser Ser Asp Leu Pro 
                85                  90                  95      


Ala Ser Ala Ser Gln Ser Ala Gly Ile Thr Gly Val Asn His Arg Ala 
            100                 105                 110         


Gln Pro Gly Leu Asn Val Ser Val Asp Lys Phe Thr Ala Met Ser Ser 
        115                 120                 125             


His Phe Thr Gln Asp Leu Leu Pro Glu Gln Gly Ile Gln Asp Ala Phe 
    130                 135                 140                 


Pro Lys Arg Ile Leu Arg Gly Tyr Gly Asn Cys Gly Leu Asp Asn Leu 
145                 150                 155                 160 


Tyr Leu Arg Lys Asp Trp Glu Ser Leu Asp Glu Cys Lys Leu Gln Lys 
                165                 170                 175     


Asp Tyr Asn Gly Leu Asn Gln Cys Ser Ser Thr Thr His Ser Lys Ile 
            180                 185                 190         


Phe Gln Tyr Asn Lys Tyr Val Lys Ile 
        195                 200     

<210>  2716
<211>  637
<212>  DNA
<213>  Homo sapiens

<400>  2716
aatcaggcac atgtctggag aggagaggac ggcttccggg atctagcggg gcctttgtcc     60

cgacagagct ccacttcctg tccccgcggc tctgtgtccc ctgctagccg taggtcgtgt    120

gacccgcagg caccgggaga tccagaagtg aaacgccagg ctctctggag gccaggagat    180

gactctgttg acgttcaggg atgtggccat agaattctcc ctggaggagt ggaaatgcct    240

ggacctcgct cagcagaatt tgtacaggga tgtgatgttg gagaactaca gaaacttgtt    300

ctccgttggt ctcactgtct gtaagccagg cctgatcacc tgcctggagc aacgaaaaga    360

gccctggaat gtgaagagac aggaggcagc agacggacat ccagctatgt cttctcattt    420

tacccaagac cttctgccag agcagggcat acaagatgca ttcccaaaaa gaatactgag    480

aggatatgga aattgtggcc ttgataattt atatttaagg aaagactggg aaagtttaga    540

tgagtgtaag ttgcaaaaag attataatgg acttaaccaa tgttcatcaa ctacccatag    600

caaaatcttt caatataata aatatgttaa aatcttt                             637


<210>  2717
<211>  152
<212>  PRT
<213>  Homo sapiens

<400>  2717


Met Thr Leu Leu Thr Phe Arg Asp Val Ala Ile Glu Phe Ser Leu Glu 
1               5                   10                  15      


Glu Trp Lys Cys Leu Asp Leu Ala Gln Gln Asn Leu Tyr Arg Asp Val 
            20                  25                  30          


Met Leu Glu Asn Tyr Arg Asn Leu Phe Ser Val Gly Leu Thr Val Cys 
        35                  40                  45              


Lys Pro Gly Leu Ile Thr Cys Leu Glu Gln Arg Lys Glu Pro Trp Asn 
    50                  55                  60                  


Val Lys Arg Gln Glu Ala Ala Asp Gly His Pro Ala Met Ser Ser His 
65                  70                  75                  80  


Phe Thr Gln Asp Leu Leu Pro Glu Gln Gly Ile Gln Asp Ala Phe Pro 
                85                  90                  95      


Lys Arg Ile Leu Arg Gly Tyr Gly Asn Cys Gly Leu Asp Asn Leu Tyr 
            100                 105                 110         


Leu Arg Lys Asp Trp Glu Ser Leu Asp Glu Cys Lys Leu Gln Lys Asp 
        115                 120                 125             


Tyr Asn Gly Leu Asn Gln Cys Ser Ser Thr Thr His Ser Lys Ile Phe 
    130                 135                 140                 


Gln Tyr Asn Lys Tyr Val Lys Ile 
145                 150         

<210>  2718
<211>  703
<212>  DNA
<213>  Homo sapiens

<400>  2718
ctgtccccgc ggctctgtgt cccctgctag ccgtaggtcg tgtgacccgc aggcaccggg     60

agatccagaa gtgaaacgcc aggctctctg gaggccagga gatggcacag acaccttacc    120

agaatgtctt tggtttgagg ttccactttg gaaacttgac agggtgattt gctctcagcc    180

accctctgga ctttttcctc agtttcagta ttgtccaggg ataacacagg atgcccacca    240

tggccatgtc tgctggagca tctagtgaat ttcaggccct gggttatttc tcagaggaca    300

gcctgaggta tgaagtgtgg cctctccagg gagcagctgg atgccctggg ctgagagaaa    360

tctcctggtc tactcttcct ctaaagagac tctgttgacg ttcagggatg tggccataga    420

attctccctg gaggagtgga aatgcctgga cctcgctcag cagaatttgt acagggatgt    480

gatgttggag aactacagaa acttgttctc cgttggtctc actgtctgta agccaggcct    540

gatcacctgc ctggagcaac gaaaagagcc ctggaatgtg aagagacagg aggcagcaga    600

cggacatcca gagatgggat ttcaccatgc tactcaggct tgtcttgaac tcctgggctc    660

aagcgatctg cctgcctcag cctcccaaag tgctgggatt aca                      703


<210>  2719
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  2719


Met Pro Trp Ala Glu Arg Asn Leu Leu Val Tyr Ser Ser Ser Lys Glu 
1               5                   10                  15      


Thr Leu Leu Thr Phe Arg Asp Val Ala Ile Glu Phe Ser Leu Glu Glu 
            20                  25                  30          


Trp Lys Cys Leu Asp Leu Ala Gln Gln Asn Leu Tyr Arg Asp Val Met 
        35                  40                  45              


Leu Glu Asn Tyr Arg Asn Leu Phe Ser Val Gly Leu Thr Val Cys Lys 
    50                  55                  60                  


Pro Gly Leu Ile Thr Cys Leu Glu Gln Arg Lys Glu Pro Trp Asn Val 
65                  70                  75                  80  


Lys Arg Gln Glu Ala Ala Asp Gly His Pro Glu Met Gly Phe His His 
                85                  90                  95      


Ala Thr Gln Ala Cys Leu Glu Leu Leu Gly Ser Ser Asp Leu Pro Ala 
            100                 105                 110         


Ser Ala Ser Gln Ser Ala Gly Ile 
        115                 120 

<210>  2720
<211>  635
<212>  DNA
<213>  Homo sapiens

<400>  2720
aatcaggcac atgtctggag aggagaggac ggcttccggg atctagcggg gcctttgtcc     60

cgacagagct ccacttcctg tccccgcggc tctgtgtccc ctgctagccg taggtcgtgt    120

gacccgcagg caccgggaga tccagaagtg aaacgccagg ctctctggag gccaggagat    180

ggtgtgattt gtccagagaa tctttcctaa gaggaaatcc cagagaagca ggagaaagag    240

aaagaaatgg ctggtgctca gactctgttg acgttcaggg atgtggccat agaattctcc    300

ctggaggagt ggaaatgcct ggacctcgct cagcagaatt tgtacaggga tgtgatgttg    360

gagaactaca gaaacttgtt ctccgttggt ctcactgtct gtaagccagg cctgatcacc    420

tgcctggagc aacgaaaaga gccctggaat gtgaagagac aggaggcagc agacggacat    480

ccaggtattt tctttgtggt taccatggaa attatataaa acatcttaaa gttacaacaa    540

ggtattttac actgagatgg gatttcacca tgctactcag gcttgtcttg aactcctggg    600

ctcaagcgat ctgcctgcct cagcctccca aagtg                               635


<210>  2721
<211>  90
<212>  PRT
<213>  Homo sapiens

<400>  2721


Met Ala Gly Ala Gln Thr Leu Leu Thr Phe Arg Asp Val Ala Ile Glu 
1               5                   10                  15      


Phe Ser Leu Glu Glu Trp Lys Cys Leu Asp Leu Ala Gln Gln Asn Leu 
            20                  25                  30          


Tyr Arg Asp Val Met Leu Glu Asn Tyr Arg Asn Leu Phe Ser Val Gly 
        35                  40                  45              


Leu Thr Val Cys Lys Pro Gly Leu Ile Thr Cys Leu Glu Gln Arg Lys 
    50                  55                  60                  


Glu Pro Trp Asn Val Lys Arg Gln Glu Ala Ala Asp Gly His Pro Gly 
65                  70                  75                  80  


Ile Phe Phe Val Val Thr Met Glu Ile Ile 
                85                  90  

<210>  2722
<211>  427
<212>  DNA
<213>  Homo sapiens

<400>  2722
gtcccgacag agctccactt cctgtccccg cggctctgtg tcccctgcta gccgtaggtc     60

gtgtgacccg caggcaccgg gagatccaga agtgaaacgc caggctctct ggaggccagg    120

agatgactct gttgacgttc agggatgtgg ccatagaatt ctccctggag gagtggaaat    180

gcctggacct cgctcagcag aatttgtaca gggatgtgat gttggagaac tacagaaact    240

tgttctccgt tggtctcact gtctgtaagc caggcctgat cacctgcctg gagcaacgaa    300

aagagccctg gaatgtgaag agacaggagg cagcagacgg acatccagag atgggatttc    360

accatgctac tcaggcttgt cttgaactcc tgggctcaag cgatctgcct gcctcagcct    420

cccaaag                                                              427


<210>  2723
<211>  100
<212>  PRT
<213>  Homo sapiens

<400>  2723


Met Thr Leu Leu Thr Phe Arg Asp Val Ala Ile Glu Phe Ser Leu Glu 
1               5                   10                  15      


Glu Trp Lys Cys Leu Asp Leu Ala Gln Gln Asn Leu Tyr Arg Asp Val 
            20                  25                  30          


Met Leu Glu Asn Tyr Arg Asn Leu Phe Ser Val Gly Leu Thr Val Cys 
        35                  40                  45              


Lys Pro Gly Leu Ile Thr Cys Leu Glu Gln Arg Lys Glu Pro Trp Asn 
    50                  55                  60                  


Val Lys Arg Gln Glu Ala Ala Asp Gly His Pro Glu Met Gly Phe His 
65                  70                  75                  80  


His Ala Thr Gln Ala Cys Leu Glu Leu Leu Gly Ser Ser Asp Leu Pro 
                85                  90                  95      


Ala Ser Ala Ser 
            100 

<210>  2724
<211>  607
<212>  DNA
<213>  Homo sapiens

<400>  2724
gtcccgacag agctccactt cctgtccccg cggctctgtg tcccctgcta gccgtaggtc     60

gtgtgacccg caggcaccgg gagatccaga agtgaaacgc caggctctct ggaggccagg    120

agatgactct gttgacgttc agggatgtgg ccatagaatt ctccctggag gagtggaaat    180

gcctggacct cgctcagcag aatttgtaca gggatgtgat gttggagaac tacagaaact    240

tgttctccgt tggtctcact gtctgtaagc caggcctgat cacctgcctg gagcaacgaa    300

aagagccctg gaatgtgaag agacaggagg cagcagacgg acatccagca tccgcaaacg    360

tttagcttgt ctttatatct tgacaattgt gaataatgct gcagtgaaca tgagggagca    420

gataattctt caagatgctg cttttattcc cttcagttat tatatacaca gaagtgtgat    480

tgctgcgttg cagggtattt tctttgtggt taccatggaa attatataaa acatcttaaa    540

gttacaacaa ggttgtactt tttttgagac agggatttat tctgtcactc aggctggaag    600

tgcagtg                                                              607


<210>  2725
<211>  80
<212>  PRT
<213>  Homo sapiens

<400>  2725


Met Thr Leu Leu Thr Phe Arg Asp Val Ala Ile Glu Phe Ser Leu Glu 
1               5                   10                  15      


Glu Trp Lys Cys Leu Asp Leu Ala Gln Gln Asn Leu Tyr Arg Asp Val 
            20                  25                  30          


Met Leu Glu Asn Tyr Arg Asn Leu Phe Ser Val Gly Leu Thr Val Cys 
        35                  40                  45              


Lys Pro Gly Leu Ile Thr Cys Leu Glu Gln Arg Lys Glu Pro Trp Asn 
    50                  55                  60                  


Val Lys Arg Gln Glu Ala Ala Asp Gly His Pro Ala Ser Ala Asn Val 
65                  70                  75                  80  

<210>  2726
<211>  562
<212>  DNA
<213>  Homo sapiens

<400>  2726
gtcccgacag agctccactt cctgtccccg cggctctgtg tcccctgcta gccgtaggtc     60

gtgtgacccg caggcaccgg gagatccaga agtgaaacgc caggctctct ggaggccagg    120

agatgactct gttgacgttc agggatgtgg ccatagaatt ctccctggag gagtggaaat    180

gcctggacct cgctcagcag aatttgtaca gggatgtgat gttggagaac tacagaaact    240

tgttctccgt tggtctcact gtctgtaagc caggcctgat cacctgcctg gagcaacgaa    300

aagagccctg gaatgtgaag agacaggagg cagcagacgg acatccagag tttcactcta    360

tcacccaggc tgtagtgcag tggtgccatc tcagctcact gcaacctctg cttcctgggc    420

tcgagccttc ttcccacttc agcctcctga ggacctggaa ctacaggggc acaccgccac    480

acccagctaa cttttgtgtt tttaatagag acagggtttt gccatgttgc ccaggctggt    540

ctcggactcc tgggctcaag tg                                             562


<210>  2727
<211>  145
<212>  PRT
<213>  Homo sapiens

<400>  2727


Met Thr Leu Leu Thr Phe Arg Asp Val Ala Ile Glu Phe Ser Leu Glu 
1               5                   10                  15      


Glu Trp Lys Cys Leu Asp Leu Ala Gln Gln Asn Leu Tyr Arg Asp Val 
            20                  25                  30          


Met Leu Glu Asn Tyr Arg Asn Leu Phe Ser Val Gly Leu Thr Val Cys 
        35                  40                  45              


Lys Pro Gly Leu Ile Thr Cys Leu Glu Gln Arg Lys Glu Pro Trp Asn 
    50                  55                  60                  


Val Lys Arg Gln Glu Ala Ala Asp Gly His Pro Glu Phe His Ser Ile 
65                  70                  75                  80  


Thr Gln Ala Val Val Gln Trp Cys His Leu Ser Ser Leu Gln Pro Leu 
                85                  90                  95      


Leu Pro Gly Leu Glu Pro Ser Ser His Phe Ser Leu Leu Arg Thr Trp 
            100                 105                 110         


Asn Tyr Arg Gly Thr Pro Pro His Pro Ala Asn Phe Cys Val Phe Asn 
        115                 120                 125             


Arg Asp Arg Val Leu Pro Cys Cys Pro Gly Trp Ser Arg Thr Pro Gly 
    130                 135                 140                 


Leu 
145 

<210>  2728
<211>  670
<212>  DNA
<213>  Homo sapiens

<400>  2728
gtcccgacag agctccactt cctgtccccg cggctctgtg tcccctgcta gccgtaggtc     60

gtgtgacccg caggcaccgg gagatccaga agtgaaacgc caggctctct ggaggccagg    120

agatgactct gttgacgttc agggatgtgg ccatagaatt ctccctggag gagtggaaat    180

gcctggacct cgctcagcag aatttgtaca gggatgtgat gttggagaac tacagaaact    240

tgttctccgt tggtctcact gtctgtaagc caggcctgat cacctgcctg gagcaacgaa    300

aagagccctg gaatgtgaag agacaggagg cagcagacgg acatccagca tccgcaaacg    360

tttagcttgt ctttatatct tgacaattgt gaataatgct gcagtgaaca tgagggagca    420

gataattctt caagatgctg cttttattcc cttcagttat tatatacaca gaagtgtgat    480

tgctgcgttg cagggaccaa gtgttgaaga gactatactg tctgtattgt atcttcttcg    540

tgaacttgtg aaagattaag tttcactcta tcacccaggc tgtagtgcag tggtgccatc    600

tcagctcact gcaacctctg cttcctgggc tcgagccttc ttcccacttc agcctcctga    660

ggacctggaa                                                           670


<210>  2729
<211>  80
<212>  PRT
<213>  Homo sapiens

<400>  2729


Met Thr Leu Leu Thr Phe Arg Asp Val Ala Ile Glu Phe Ser Leu Glu 
1               5                   10                  15      


Glu Trp Lys Cys Leu Asp Leu Ala Gln Gln Asn Leu Tyr Arg Asp Val 
            20                  25                  30          


Met Leu Glu Asn Tyr Arg Asn Leu Phe Ser Val Gly Leu Thr Val Cys 
        35                  40                  45              


Lys Pro Gly Leu Ile Thr Cys Leu Glu Gln Arg Lys Glu Pro Trp Asn 
    50                  55                  60                  


Val Lys Arg Gln Glu Ala Ala Asp Gly His Pro Ala Ser Ala Asn Val 
65                  70                  75                  80  

<210>  2730
<211>  519
<212>  DNA
<213>  Homo sapiens

<400>  2730
aatcaggcac atgtctggag aggagaggac ggcttccggg atctagcggg gcctttgtcc     60

cgacagagct ccacttcctg tccccgcggc tctgtgtccc ctgctagccg taggtcgtgt    120

gacccgcagg caccgggaga tccagaagtg aaacgccagg ctctctggag gccaggagat    180

ggtgtgattt gtccagagaa tctttcctaa gaggaaatcc cagagaagca ggagaaagag    240

aaagaaatgg ctggtgctca gactctgttg acgttcaggg atgtggccat agaattctcc    300

ctggaggagt ggaaatgcct ggacctcgct cagcagaatt tgtacaggga tgtgatgttg    360

gagaactaca gaaacttgtt ctccgttggt ctcactgtct gtaagccagg cctgatcacc    420

tgcctggagc aacgaaaaga gccctggaat gtgaagagac aggaggcagc agacggacat    480

ccaggaccaa gtgttgaaga gactatactg tctgtattg                           519


<210>  2731
<211>  90
<212>  PRT
<213>  Homo sapiens

<400>  2731


Met Ala Gly Ala Gln Thr Leu Leu Thr Phe Arg Asp Val Ala Ile Glu 
1               5                   10                  15      


Phe Ser Leu Glu Glu Trp Lys Cys Leu Asp Leu Ala Gln Gln Asn Leu 
            20                  25                  30          


Tyr Arg Asp Val Met Leu Glu Asn Tyr Arg Asn Leu Phe Ser Val Gly 
        35                  40                  45              


Leu Thr Val Cys Lys Pro Gly Leu Ile Thr Cys Leu Glu Gln Arg Lys 
    50                  55                  60                  


Glu Pro Trp Asn Val Lys Arg Gln Glu Ala Ala Asp Gly His Pro Gly 
65                  70                  75                  80  


Pro Ser Val Glu Glu Thr Ile Leu Ser Val 
                85                  90  

<210>  2732
<211>  610
<212>  DNA
<213>  Homo sapiens

<400>  2732
gtcccgacag agctccactt cctgtccccg cggctctgtg tcccctgcta gccgtaggtc     60

gtgtgacccg caggcaccgg gagatccaga agtgaaacgc caggctctct ggaggccagg    120

agatgactct gttgacgttc agggatgtgg ccatagaatt ctccctggag gagtggaaat    180

gcctggacct cgctcagcag aatttgtaca gggatgtgat gttggagaac tacagaaact    240

tgttctccgt tggtctcact gtctgtaagc caggcctgat cacctgcctg gagcaacgaa    300

aagagccctg gaatgtgaag agacaggagg cagcagacgg acatccagca tccgcaaacg    360

tttagcttgt ctttatatct tgacaattgt gaataatgct gcagtgaaca tgagggagca    420

gataattctt caagatgctg cttttattcc cttcagttat tatatacaca gaagtgtgat    480

tgctgcgttg cagggtaggt ttatcttttt ctaactttta aataacgccc ccccaccctg    540

gttttcataa tgactctacc agttgagaac tctgagcgtt cagaattgtt ttttctttac    600

atccttatca                                                           610


<210>  2733
<211>  80
<212>  PRT
<213>  Homo sapiens

<400>  2733


Met Thr Leu Leu Thr Phe Arg Asp Val Ala Ile Glu Phe Ser Leu Glu 
1               5                   10                  15      


Glu Trp Lys Cys Leu Asp Leu Ala Gln Gln Asn Leu Tyr Arg Asp Val 
            20                  25                  30          


Met Leu Glu Asn Tyr Arg Asn Leu Phe Ser Val Gly Leu Thr Val Cys 
        35                  40                  45              


Lys Pro Gly Leu Ile Thr Cys Leu Glu Gln Arg Lys Glu Pro Trp Asn 
    50                  55                  60                  


Val Lys Arg Gln Glu Ala Ala Asp Gly His Pro Ala Ser Ala Asn Val 
65                  70                  75                  80  

<210>  2734
<211>  7935
<212>  DNA
<213>  Homo sapiens

<400>  2734
ggttgtcaaa catggctgaa gcgctgccgc tgccgctact gccgctgcag ggaaaatgct     60

gagccctccc gggccgggtg ggcggcggcg gcgagggcgg cgacggggac ccgcttcccg    120

agcgcggcgg cggcggccat ggcccggctg gctgactact tcatcgtggt aggctatgac    180

cacgagaagc caggatcagg agaaggtctg gggaaaataa tccagagatt tccacagaag    240

gactgggatg atacaccttt tccacaggga attgagttgt tttgtcagcc tggcgggtgg    300

cagctgtcca gagagaggaa gcagccaacg ttctttgtgg ttgtcctgac agacattgac    360

tcagatcgac attactgctc atgcctaacc ttctatgagg cagagatcaa tcttcaggga    420

acaaagaagg aagagattga aggtgaagca aaagtgtctg gtttaattca gcctgcagaa    480

gtgtttgctc ccaaaagcct ggtgttggta tccagattat attatccaga aatttttagg    540

gcttgcctgg gtttgatcta taccgtgtat gtggacagcc tgaatgtctc cttggaaagt    600

ctaattgcaa acctttgtgc ctgccttgtc ccagcggctg gagggtctca gaagctgttt    660

tctttgggtg caggagatag acagttgatc cagactcctt tacatgatag tcttcctatc    720

acgggcacta gtgtggctct cctgttccag caattgggaa ttcaaaatgt cctcagcctc    780

ttttgtgcag tcctcacaga aaataaggtt ctcttccatt ctgcaagttt ccagagactt    840

agtgatgctt gtagagccct ggaatcttta atgtttcctc ttaaatatag ttatccttat    900

atccctattc tcccggctca gctactggaa gttctaagtt ccccaacgcc tttcattatt    960

ggagtacatt ctgtctttaa aactgatgtc catgaacttt tagatgtaat catagcagat   1020

ttggatggag gcactattaa aattcccgaa tgtattcacc tctcttccct cccagaacca   1080

cttctacatc agactcaatc agctctttct ttgattttac acccagattt ggaagtagca   1140

gatcatgctt ttcctcctcc acgaacagct ttatcccact caaaaatgct ggataaagag   1200

gtgcgagccg ttttccttag attatttgca caactcttcc aaggatatag atcctgcctg   1260

caacttataa gaattcatgc agagccagta atacatttcc acaagacagc attcttgggg   1320

cagcgtggtt tggtcgagaa tgatttcctc actaaagtac tcagtggaat ggcatttgca   1380

ggttttgttt cagaaagagg tcctccttat agatcttgtg atctctttga tgagttggta   1440

gcctttgaag tagagagaat taaagttgaa gaaaataacc cagtgaagat gataaagcat   1500

gtcagggaac ttgctgagca actattcaaa aatgagaatc caaatcctca tatggcattc   1560

cagaaagttc cacggccaac agaaggatcc catttgcgag ttcatattct tcctttccca   1620

gagattaatg aagcccgggt tcaggaatta atacaggaaa atgttgctaa gaaccagaat   1680

gcacctcctg ccacacgaat agaaaagaaa tgtgttgtgc cagcaggtcc acctgttgtt   1740

tcgataatgg acaaggtgac gacagttttc aacagtgcac aaagactaga agttgtcaga   1800

aactgtatct cattcatatt tgaaaataaa attttggaaa ctgaaaagac ccttcctgct   1860

gcactcagag cccttaaagg aaaggcagca agacagtgtc tcactgatga attgggtttg   1920

catgtccagc aaaaccgggc aatattagac catcaacagt ttgactacat aataaggatg   1980

atgaattgta ctctacagga ttgttcaagt ttagaagaat acaacattgc cgcagcatta   2040

ctccctttga ccagtgcttt ctataggaaa cttgcccctg gagtcagcca gtttgcttac   2100

acgtgtgtac aagaccaccc catttggaca aatcagcaat tttgggagac aaccttttac   2160

aatgcagtgc aggaacaggt tcgctccctt tatctctcag ccaaggaaga caatcatgcc   2220

ccgcatctga agcaaaagga taagcttcct gatgaccatt atcaggagaa gacagcaatg   2280

gacctggcag ctgagcaact acgcctttgg cctaccctga gcaagtcaac tcagcaagag   2340

ctagtgcaac atgaggaaag cactgtcttt agtcaggcca ttcactttgc aaacctcatg   2400

gtgaacctgc tagttccact cgacacaagt aaaaacaagc tcctaagaac atcagcgcca   2460

ggtgactggg agagcggaag caacagcatt gtcacaaaca gtattgcagg aagtgtagct   2520

gagagctatg atacagagag tgggtttgaa gattcagaga atactgacat tgccaattct   2580

gttgtgcggt tcattacccg atttattgac aaagtttgta cagagagtgg agttactcag   2640

gatcacatca agagccttca ttgcatgata ccaggaattg tagctatgca cattgagacc   2700

ctagaagcag tacatcgaga aagcagaaga cttccgccta ttcagaagcc caagattctt   2760

agacctgctc tgctgccagg agaagaaatt gtctgtgagg gtcttcgagt cttgctggat   2820

cctgatggaa gagaagaagc tactggaggt cttcttggag gccctcagct cctgccagca   2880

gaaggagcct tgttcctcac cacatacaga attctcttca gaggaacacc ccatgatcag   2940

ttagtgggtg agcagacagt tgtgcggagc tttcccattg cctccatcac caaggagaag   3000

aagattacaa tgcagaacca gctacagcag aacatgcaag aaggactgca gatcacatca   3060

gcatcttttc agttgattaa ggtagcattt gatgaagaag tcagtccaga agtagtagag   3120

atctttaaga aacagctgat gaagttccgt tatcctcagt ccattttcag tacctttgct   3180

tttgctgctg gacaaactac cccacaaata attttaccaa aacagaagga aaagaacact   3240

tcttttcgta ccttctcaaa aacaattgtg aaaggtgcca aaagggcagg gaaaatgaca   3300

attgggcggc aatatttact gaagaagaag acagggacaa ttgtggaaga aagagtaaat   3360

cgtcctggat ggaatgaaga tgatgatgta tctgtttcag atgagagtga gctccccaca   3420

agtaccaccc tgaaggcctc cgagaagtct acaatggaac agttggtgga aaaagcttgt   3480

ttcagagact atcagcgttt aggtttagga accataagtg gcagctcttc ccgttcaaga   3540

cccgagtatt ttagaattac tgcctccaac aggatgtatt cactctgccg gagctatcct   3600

ggccttttag tcgtacctca agctgtacag gacagtagtt taccaagagt agctcgctgc   3660

tatcgacaca atcgcctgcc tgttgtatgt tggaagaact caagaagtgg tactctgctc   3720

ctccgatctg gaggattcca tgggaaggga gtcgttggtc ttttcaaatc tcagaactcc   3780

cctcaggccg ctcctacctc ctctttagaa tcttccagta gcatagaaca agagaaatac   3840

ttgcaagcct tactgaatgc tgtttctgtc catcagaaac tcagaggcaa cagcactctt   3900

actgtcaggc cagcctttgc tctatctcca ggtgtgtggg caagtcttcg ctctagcact   3960

cgcttgatca gctctccaac atccttcatt gatgttggcg cccggctggc aggcaaggat   4020

cactcggcct ccttcagtaa cagcagctac ctacaaaacc agctcttgaa acggcaagca   4080

gccctttaca tatttggtga aaagtcgcaa ctaaggaact tcaaggtaga atttgcttta   4140

aattgtgagt ttgttcctgt tgaatttcat gaaatccggc aagtgaaagc cagttttaag   4200

aagctgatga gggcttgtat cccaagcacc atccctactg actcagaagt gaccttcctg   4260

aaagcgctgg gagattctga gtggttccca cagcttcaca ggataatgca gctggctgtg   4320

gttgtatcag aagtacttga gaatggttcc tcagttttgg tctgtttgga ggaaggctgg   4380

gacatcactg cacaagtgac atccctggtt cagttactca gtgatccctt ttataggaca   4440

cttgaaggct tccagatgtt ggttgaaaaa gagtggctct cttttggtca caaattcagt   4500

cagaggagca gcttgaccct caactgtcag gggagtggtt ttgctccagt cttcttacag   4560

ttcttagact gtgtacacca ggttcacaac cagtatccaa ctgagtttga attcaatctc   4620

tattacttaa agttcttggc tttccactat gtgtctaatc gctttaaaac atttctcctg   4680

gattcagact atgaaagatt agagcacgga actttatttg atgataaagg agaaaagcat   4740

gccaaaaaag gagtctgtat ttgggaatgt attgacagaa tgcacaagag gagtcccatt   4800

ttctttaatt atttatattc accattggaa atagaggctc taaagcccaa tgtaaacgtc   4860

tctagcctca agaagtggga ttactacata gaagagaccc tgtccacagg cccttcctat   4920

gactggatga tgctaacccc caagcacttc ccctccgaag actctgacct ggctggagaa   4980

gctgggccac ggagccagag gagaacagtg tggccatgct atgatgatgt cagctgtact   5040

cagcctgatg ctctcaccag ccttttcagt gaaattgaaa aattggagca caaattgaac   5100

caagcccctg agaagtggca gcagctgtgg gaaagggtaa ccgtggacct taaagaagaa   5160

ccaagaacag atcgctccca aagacacctg tcgagatccc caggaattgt gtctaccaac   5220

ctaccttcct atcagaagag gtctctgcta catctcccag acagcagcat gggggaggaa   5280

cagaattcca gcatctcccc atccaatgga gtggagcgaa gagcagccac gctctatagc   5340

cagtatacat ccaagaatga tgaaaacagg tcctttgagg gaacacttta taaaagaggg   5400

gctttgctga aaggttggaa gccccgttgg tttgttttgg atgtaacaaa acatcagctg   5460

cgctactatg actcaggtga ggacacaagc tgtaaaggcc acattgatct ggctgaagta   5520

gaaatggtca tccctgctgg ccccagcatg ggagccccaa agcacacaag tgacaaggct   5580

ttctttgatc tcaagaccag caaacgtgtg tataacttct gcgcccagga tggacagagt   5640

gcccagcaat ggatggacaa gatccagagt tgtatctctg atgcctgatg cccatggtca   5700

acccacgcag aagaaacaga agaactcatg ctgccagata gatagaaaaa gaagcatgga   5760

tccttgagga gctgacaaca agttatccca gggcctgagg ttctcctgcc cagtcccctc   5820

ttgcaggggt tgctatatct acttaacctg aataggtgtt tcacacaggt ctggtcaaca   5880

gccccatgca ctccctgtat cttgcactaa atttttctaa cagggtctta gtggttaatg   5940

atcagaagat gtctcctgag ccaactgtga acctcaccca ggcaaaatgg ctaccaccta   6000

cttgggtcct tcttcatgaa agctatagat ccttttttgt tctctgaggt cataatttcc   6060

tcggagacct gtttaacaag caaaaatcaa aaccctccaa gattgtctca tattctacct   6120

ggactaggtt tcctatgaga gacatctact tgtaatgcct gacctttgag atgctcagtt   6180

ctctggtgct gccaaaagat gcttccatgg tccgtgctct gccagtgggg ttcacaacaa   6240

gagacgtcat tgttcagtag caggcaaaga gggagcacac agcattattc tgatggaaaa   6300

agattatcca gggaatggta caacaatgac cagcccaatg caggaaaaca ctacttccaa   6360

aacactgaat tctctagacc agaggtgctc tgaggatcca gggccttgtg ttcttatgta   6420

tcttctgctt cctgacagct tctttttcaa aataacatgc aaaaaaagct gaatgcacta   6480

actcacaaaa caaacacttg cactgaattc ccaatgaagt gaagatgttg gaaagacaga   6540

ggccagctat ttaggaccat acgcacctgt gacaagggct gtgttgacca cagtcacact   6600

gtggcatgac tggataccca aactacactt ctacacatga aaagtaagaa ctgtctttag   6660

attttcttta ctttgataac ttgtgattgt ttagcttaag acccaagaaa tgctgtttgc   6720

tcatggtaaa cagaaacagc atcttcgcta caaccactga caccagctgg cgtcataggt   6780

agctagatca ttgcatttgt tttgaaatgt taatatgtta aatactaaac taatatttca   6840

aaaatgtgta tatatgattt ctatatcctt gtttttcaga tagcctgctt ataatttaat   6900

ataaattaac tgatgcattc ataagatttc aataatgaaa tggttccctt ttaaaaaata   6960

aaaatacttt gtagattaaa aataaatcag aatttcaaat ttaaaattgt ccacacacta   7020

ggaaatagaa ctgtgttaat atataagaaa tctggggata attaagaatg aaggactttt   7080

ctatcatttc cattttataa attgccacct gtgaaaatgg tttttgcaca ttatttgtat   7140

ttttctttgt atatgaaata attttttgta ctttgtaaaa tatggagccc attgtacctt   7200

cagctatttg agactataca cagtgcttct tttgtaactg gattacttta actttcgtga   7260

aggcattaca ttgcctcaca ttcactaacc accttgaatt aaatttattt cttaagaaaa   7320

agcatccctc atttactgtg aactaaagtt cattctgtag tgcacagcat tcaggagggt   7380

aacactcagg attcatacat gggactaaag gttcaagaat aaaacaaagc atgacccact   7440

ttgttccttc attctcctaa tgtcatcact gccctttgct caagaagtaa ctagggatac   7500

tggacatgtt agcatgagct tctgggttcc agacacactt ctgcagagtt taggtaagag   7560

acttgaggcc aagattctca tatgtgctgc cactcctacc actgtctcta ataagctgtt   7620

tgaaattgct taagtccctt acctattctg ggtccattcc accacccaga gtatatggta   7680

atttgtgaaa attttaggca tgagacattg aagtctgttt gagcagcaga tttttctgct   7740

tcagggaact tttttttttt tttttttttt gagacagagt ctcactctgt tgcccaggct   7800

ctggagttct ggagtgcagt ggcgcaatct cggctcactg caagctccac ctcccgggtt   7860

cacaccattc tcctgcctca gcctcccaag tagctgggac tacaggggcc caccaccacg   7920

cccagctaat ttttt                                                    7935


<210>  2735
<211>  1849
<212>  PRT
<213>  Homo sapiens

<400>  2735


Met Ala Arg Leu Ala Asp Tyr Phe Ile Val Val Gly Tyr Asp His Glu 
1               5                   10                  15      


Lys Pro Gly Ser Gly Glu Gly Leu Gly Lys Ile Ile Gln Arg Phe Pro 
            20                  25                  30          


Gln Lys Asp Trp Asp Asp Thr Pro Phe Pro Gln Gly Ile Glu Leu Phe 
        35                  40                  45              


Cys Gln Pro Gly Gly Trp Gln Leu Ser Arg Glu Arg Lys Gln Pro Thr 
    50                  55                  60                  


Phe Phe Val Val Val Leu Thr Asp Ile Asp Ser Asp Arg His Tyr Cys 
65                  70                  75                  80  


Ser Cys Leu Thr Phe Tyr Glu Ala Glu Ile Asn Leu Gln Gly Thr Lys 
                85                  90                  95      


Lys Glu Glu Ile Glu Gly Glu Ala Lys Val Ser Gly Leu Ile Gln Pro 
            100                 105                 110         


Ala Glu Val Phe Ala Pro Lys Ser Leu Val Leu Val Ser Arg Leu Tyr 
        115                 120                 125             


Tyr Pro Glu Ile Phe Arg Ala Cys Leu Gly Leu Ile Tyr Thr Val Tyr 
    130                 135                 140                 


Val Asp Ser Leu Asn Val Ser Leu Glu Ser Leu Ile Ala Asn Leu Cys 
145                 150                 155                 160 


Ala Cys Leu Val Pro Ala Ala Gly Gly Ser Gln Lys Leu Phe Ser Leu 
                165                 170                 175     


Gly Ala Gly Asp Arg Gln Leu Ile Gln Thr Pro Leu His Asp Ser Leu 
            180                 185                 190         


Pro Ile Thr Gly Thr Ser Val Ala Leu Leu Phe Gln Gln Leu Gly Ile 
        195                 200                 205             


Gln Asn Val Leu Ser Leu Phe Cys Ala Val Leu Thr Glu Asn Lys Val 
    210                 215                 220                 


Leu Phe His Ser Ala Ser Phe Gln Arg Leu Ser Asp Ala Cys Arg Ala 
225                 230                 235                 240 


Leu Glu Ser Leu Met Phe Pro Leu Lys Tyr Ser Tyr Pro Tyr Ile Pro 
                245                 250                 255     


Ile Leu Pro Ala Gln Leu Leu Glu Val Leu Ser Ser Pro Thr Pro Phe 
            260                 265                 270         


Ile Ile Gly Val His Ser Val Phe Lys Thr Asp Val His Glu Leu Leu 
        275                 280                 285             


Asp Val Ile Ile Ala Asp Leu Asp Gly Gly Thr Ile Lys Ile Pro Glu 
    290                 295                 300                 


Cys Ile His Leu Ser Ser Leu Pro Glu Pro Leu Leu His Gln Thr Gln 
305                 310                 315                 320 


Ser Ala Leu Ser Leu Ile Leu His Pro Asp Leu Glu Val Ala Asp His 
                325                 330                 335     


Ala Phe Pro Pro Pro Arg Thr Ala Leu Ser His Ser Lys Met Leu Asp 
            340                 345                 350         


Lys Glu Val Arg Ala Val Phe Leu Arg Leu Phe Ala Gln Leu Phe Gln 
        355                 360                 365             


Gly Tyr Arg Ser Cys Leu Gln Leu Ile Arg Ile His Ala Glu Pro Val 
    370                 375                 380                 


Ile His Phe His Lys Thr Ala Phe Leu Gly Gln Arg Gly Leu Val Glu 
385                 390                 395                 400 


Asn Asp Phe Leu Thr Lys Val Leu Ser Gly Met Ala Phe Ala Gly Phe 
                405                 410                 415     


Val Ser Glu Arg Gly Pro Pro Tyr Arg Ser Cys Asp Leu Phe Asp Glu 
            420                 425                 430         


Leu Val Ala Phe Glu Val Glu Arg Ile Lys Val Glu Glu Asn Asn Pro 
        435                 440                 445             


Val Lys Met Ile Lys His Val Arg Glu Leu Ala Glu Gln Leu Phe Lys 
    450                 455                 460                 


Asn Glu Asn Pro Asn Pro His Met Ala Phe Gln Lys Val Pro Arg Pro 
465                 470                 475                 480 


Thr Glu Gly Ser His Leu Arg Val His Ile Leu Pro Phe Pro Glu Ile 
                485                 490                 495     


Asn Glu Ala Arg Val Gln Glu Leu Ile Gln Glu Asn Val Ala Lys Asn 
            500                 505                 510         


Gln Asn Ala Pro Pro Ala Thr Arg Ile Glu Lys Lys Cys Val Val Pro 
        515                 520                 525             


Ala Gly Pro Pro Val Val Ser Ile Met Asp Lys Val Thr Thr Val Phe 
    530                 535                 540                 


Asn Ser Ala Gln Arg Leu Glu Val Val Arg Asn Cys Ile Ser Phe Ile 
545                 550                 555                 560 


Phe Glu Asn Lys Ile Leu Glu Thr Glu Lys Thr Leu Pro Ala Ala Leu 
                565                 570                 575     


Arg Ala Leu Lys Gly Lys Ala Ala Arg Gln Cys Leu Thr Asp Glu Leu 
            580                 585                 590         


Gly Leu His Val Gln Gln Asn Arg Ala Ile Leu Asp His Gln Gln Phe 
        595                 600                 605             


Asp Tyr Ile Ile Arg Met Met Asn Cys Thr Leu Gln Asp Cys Ser Ser 
    610                 615                 620                 


Leu Glu Glu Tyr Asn Ile Ala Ala Ala Leu Leu Pro Leu Thr Ser Ala 
625                 630                 635                 640 


Phe Tyr Arg Lys Leu Ala Pro Gly Val Ser Gln Phe Ala Tyr Thr Cys 
                645                 650                 655     


Val Gln Asp His Pro Ile Trp Thr Asn Gln Gln Phe Trp Glu Thr Thr 
            660                 665                 670         


Phe Tyr Asn Ala Val Gln Glu Gln Val Arg Ser Leu Tyr Leu Ser Ala 
        675                 680                 685             


Lys Glu Asp Asn His Ala Pro His Leu Lys Gln Lys Asp Lys Leu Pro 
    690                 695                 700                 


Asp Asp His Tyr Gln Glu Lys Thr Ala Met Asp Leu Ala Ala Glu Gln 
705                 710                 715                 720 


Leu Arg Leu Trp Pro Thr Leu Ser Lys Ser Thr Gln Gln Glu Leu Val 
                725                 730                 735     


Gln His Glu Glu Ser Thr Val Phe Ser Gln Ala Ile His Phe Ala Asn 
            740                 745                 750         


Leu Met Val Asn Leu Leu Val Pro Leu Asp Thr Ser Lys Asn Lys Leu 
        755                 760                 765             


Leu Arg Thr Ser Ala Pro Gly Asp Trp Glu Ser Gly Ser Asn Ser Ile 
    770                 775                 780                 


Val Thr Asn Ser Ile Ala Gly Ser Val Ala Glu Ser Tyr Asp Thr Glu 
785                 790                 795                 800 


Ser Gly Phe Glu Asp Ser Glu Asn Thr Asp Ile Ala Asn Ser Val Val 
                805                 810                 815     


Arg Phe Ile Thr Arg Phe Ile Asp Lys Val Cys Thr Glu Ser Gly Val 
            820                 825                 830         


Thr Gln Asp His Ile Lys Ser Leu His Cys Met Ile Pro Gly Ile Val 
        835                 840                 845             


Ala Met His Ile Glu Thr Leu Glu Ala Val His Arg Glu Ser Arg Arg 
    850                 855                 860                 


Leu Pro Pro Ile Gln Lys Pro Lys Ile Leu Arg Pro Ala Leu Leu Pro 
865                 870                 875                 880 


Gly Glu Glu Ile Val Cys Glu Gly Leu Arg Val Leu Leu Asp Pro Asp 
                885                 890                 895     


Gly Arg Glu Glu Ala Thr Gly Gly Leu Leu Gly Gly Pro Gln Leu Leu 
            900                 905                 910         


Pro Ala Glu Gly Ala Leu Phe Leu Thr Thr Tyr Arg Ile Leu Phe Arg 
        915                 920                 925             


Gly Thr Pro His Asp Gln Leu Val Gly Glu Gln Thr Val Val Arg Ser 
    930                 935                 940                 


Phe Pro Ile Ala Ser Ile Thr Lys Glu Lys Lys Ile Thr Met Gln Asn 
945                 950                 955                 960 


Gln Leu Gln Gln Asn Met Gln Glu Gly Leu Gln Ile Thr Ser Ala Ser 
                965                 970                 975     


Phe Gln Leu Ile Lys Val Ala Phe Asp Glu Glu Val Ser Pro Glu Val 
            980                 985                 990         


Val Glu Ile Phe Lys Lys Gln Leu  Met Lys Phe Arg Tyr  Pro Gln Ser 
        995                 1000                 1005             


Ile Phe  Ser Thr Phe Ala Phe  Ala Ala Gly Gln Thr  Thr Pro Gln 
    1010                 1015                 1020             


Ile Ile  Leu Pro Lys Gln Lys  Glu Lys Asn Thr Ser  Phe Arg Thr 
    1025                 1030                 1035             


Phe Ser  Lys Thr Ile Val Lys  Gly Ala Lys Arg Ala  Gly Lys Met 
    1040                 1045                 1050             


Thr Ile  Gly Arg Gln Tyr Leu  Leu Lys Lys Lys Thr  Gly Thr Ile 
    1055                 1060                 1065             


Val Glu  Glu Arg Val Asn Arg  Pro Gly Trp Asn Glu  Asp Asp Asp 
    1070                 1075                 1080             


Val Ser  Val Ser Asp Glu Ser  Glu Leu Pro Thr Ser  Thr Thr Leu 
    1085                 1090                 1095             


Lys Ala  Ser Glu Lys Ser Thr  Met Glu Gln Leu Val  Glu Lys Ala 
    1100                 1105                 1110             


Cys Phe  Arg Asp Tyr Gln Arg  Leu Gly Leu Gly Thr  Ile Ser Gly 
    1115                 1120                 1125             


Ser Ser  Ser Arg Ser Arg Pro  Glu Tyr Phe Arg Ile  Thr Ala Ser 
    1130                 1135                 1140             


Asn Arg  Met Tyr Ser Leu Cys  Arg Ser Tyr Pro Gly  Leu Leu Val 
    1145                 1150                 1155             


Val Pro  Gln Ala Val Gln Asp  Ser Ser Leu Pro Arg  Val Ala Arg 
    1160                 1165                 1170             


Cys Tyr  Arg His Asn Arg Leu  Pro Val Val Cys Trp  Lys Asn Ser 
    1175                 1180                 1185             


Arg Ser  Gly Thr Leu Leu Leu  Arg Ser Gly Gly Phe  His Gly Lys 
    1190                 1195                 1200             


Gly Val  Val Gly Leu Phe Lys  Ser Gln Asn Ser Pro  Gln Ala Ala 
    1205                 1210                 1215             


Pro Thr  Ser Ser Leu Glu Ser  Ser Ser Ser Ile Glu  Gln Glu Lys 
    1220                 1225                 1230             


Tyr Leu  Gln Ala Leu Leu Asn  Ala Val Ser Val His  Gln Lys Leu 
    1235                 1240                 1245             


Arg Gly  Asn Ser Thr Leu Thr  Val Arg Pro Ala Phe  Ala Leu Ser 
    1250                 1255                 1260             


Pro Gly  Val Trp Ala Ser Leu  Arg Ser Ser Thr Arg  Leu Ile Ser 
    1265                 1270                 1275             


Ser Pro  Thr Ser Phe Ile Asp  Val Gly Ala Arg Leu  Ala Gly Lys 
    1280                 1285                 1290             


Asp His  Ser Ala Ser Phe Ser  Asn Ser Ser Tyr Leu  Gln Asn Gln 
    1295                 1300                 1305             


Leu Leu  Lys Arg Gln Ala Ala  Leu Tyr Ile Phe Gly  Glu Lys Ser 
    1310                 1315                 1320             


Gln Leu  Arg Asn Phe Lys Val  Glu Phe Ala Leu Asn  Cys Glu Phe 
    1325                 1330                 1335             


Val Pro  Val Glu Phe His Glu  Ile Arg Gln Val Lys  Ala Ser Phe 
    1340                 1345                 1350             


Lys Lys  Leu Met Arg Ala Cys  Ile Pro Ser Thr Ile  Pro Thr Asp 
    1355                 1360                 1365             


Ser Glu  Val Thr Phe Leu Lys  Ala Leu Gly Asp Ser  Glu Trp Phe 
    1370                 1375                 1380             


Pro Gln  Leu His Arg Ile Met  Gln Leu Ala Val Val  Val Ser Glu 
    1385                 1390                 1395             


Val Leu  Glu Asn Gly Ser Ser  Val Leu Val Cys Leu  Glu Glu Gly 
    1400                 1405                 1410             


Trp Asp  Ile Thr Ala Gln Val  Thr Ser Leu Val Gln  Leu Leu Ser 
    1415                 1420                 1425             


Asp Pro  Phe Tyr Arg Thr Leu  Glu Gly Phe Gln Met  Leu Val Glu 
    1430                 1435                 1440             


Lys Glu  Trp Leu Ser Phe Gly  His Lys Phe Ser Gln  Arg Ser Ser 
    1445                 1450                 1455             


Leu Thr  Leu Asn Cys Gln Gly  Ser Gly Phe Ala Pro  Val Phe Leu 
    1460                 1465                 1470             


Gln Phe  Leu Asp Cys Val His  Gln Val His Asn Gln  Tyr Pro Thr 
    1475                 1480                 1485             


Glu Phe  Glu Phe Asn Leu Tyr  Tyr Leu Lys Phe Leu  Ala Phe His 
    1490                 1495                 1500             


Tyr Val  Ser Asn Arg Phe Lys  Thr Phe Leu Leu Asp  Ser Asp Tyr 
    1505                 1510                 1515             


Glu Arg  Leu Glu His Gly Thr  Leu Phe Asp Asp Lys  Gly Glu Lys 
    1520                 1525                 1530             


His Ala  Lys Lys Gly Val Cys  Ile Trp Glu Cys Ile  Asp Arg Met 
    1535                 1540                 1545             


His Lys  Arg Ser Pro Ile Phe  Phe Asn Tyr Leu Tyr  Ser Pro Leu 
    1550                 1555                 1560             


Glu Ile  Glu Ala Leu Lys Pro  Asn Val Asn Val Ser  Ser Leu Lys 
    1565                 1570                 1575             


Lys Trp  Asp Tyr Tyr Ile Glu  Glu Thr Leu Ser Thr  Gly Pro Ser 
    1580                 1585                 1590             


Tyr Asp  Trp Met Met Leu Thr  Pro Lys His Phe Pro  Ser Glu Asp 
    1595                 1600                 1605             


Ser Asp  Leu Ala Gly Glu Ala  Gly Pro Arg Ser Gln  Arg Arg Thr 
    1610                 1615                 1620             


Val Trp  Pro Cys Tyr Asp Asp  Val Ser Cys Thr Gln  Pro Asp Ala 
    1625                 1630                 1635             


Leu Thr  Ser Leu Phe Ser Glu  Ile Glu Lys Leu Glu  His Lys Leu 
    1640                 1645                 1650             


Asn Gln  Ala Pro Glu Lys Trp  Gln Gln Leu Trp Glu  Arg Val Thr 
    1655                 1660                 1665             


Val Asp  Leu Lys Glu Glu Pro  Arg Thr Asp Arg Ser  Gln Arg His 
    1670                 1675                 1680             


Leu Ser  Arg Ser Pro Gly Ile  Val Ser Thr Asn Leu  Pro Ser Tyr 
    1685                 1690                 1695             


Gln Lys  Arg Ser Leu Leu His  Leu Pro Asp Ser Ser  Met Gly Glu 
    1700                 1705                 1710             


Glu Gln  Asn Ser Ser Ile Ser  Pro Ser Asn Gly Val  Glu Arg Arg 
    1715                 1720                 1725             


Ala Ala  Thr Leu Tyr Ser Gln  Tyr Thr Ser Lys Asn  Asp Glu Asn 
    1730                 1735                 1740             


Arg Ser  Phe Glu Gly Thr Leu  Tyr Lys Arg Gly Ala  Leu Leu Lys 
    1745                 1750                 1755             


Gly Trp  Lys Pro Arg Trp Phe  Val Leu Asp Val Thr  Lys His Gln 
    1760                 1765                 1770             


Leu Arg  Tyr Tyr Asp Ser Gly  Glu Asp Thr Ser Cys  Lys Gly His 
    1775                 1780                 1785             


Ile Asp  Leu Ala Glu Val Glu  Met Val Ile Pro Ala  Gly Pro Ser 
    1790                 1795                 1800             


Met Gly  Ala Pro Lys His Thr  Ser Asp Lys Ala Phe  Phe Asp Leu 
    1805                 1810                 1815             


Lys Thr  Ser Lys Arg Val Tyr  Asn Phe Cys Ala Gln  Asp Gly Gln 
    1820                 1825                 1830             


Ser Ala  Gln Gln Trp Met Asp  Lys Ile Gln Ser Cys  Ile Ser Asp 
    1835                 1840                 1845             


Ala 
    

<210>  2736
<211>  7340
<212>  DNA
<213>  Homo sapiens

<400>  2736
ggttgtcaaa catggctgaa gcgctgccgc tgccgctact gccgctgcag ggaaaatgct     60

gagccctccc gggccgggtg ggcggcggcg gcgagggcgg cgacggggac ccgcttcccg    120

agcgcggcgg cggcggccat ggcccggctg gctgactact tcatcgtggt aggctatgac    180

cacgagaagc caggatcagg agaaggtctg gggaaaataa tccagagatt tccacagaag    240

gactgggatg atacaccttt tccacaggga attgagttgt tttgtcagcc tggcgggtgg    300

cagctgtcca gagagaggaa gcagccaacg ttctttgtgg ttgtcctgac agacattgac    360

tcagatcgac attactgctc atgcctaacc ttctatgagg cagagatcaa tcttcaggga    420

acaaagaagg aagagattga aggtgaagca aaagtgtctg gtttaattca gcctgcagaa    480

gtgtttgctc ccaaaagcct ggtgttggta tccagattat attatccaga aatttttagg    540

gcttgcctgg gtttgatcta taccgtgtat gtggacagcc tgaatgtctc cttggaaagt    600

ctaattgcaa acctttgtgc ctgccttgtc ccagcggctg gagggtctca gaagctgttt    660

tctttgggtg caggagatag acagttgatc cagactcctt tacatgatag tcttcctatc    720

acgggcacta gtgtggctct cctgttccag caattgggaa ttcaaaatgt cctcagcctc    780

ttttgtgcag tcctcacaga aaataaggtt ctcttccatt ctgcaagttt ccagagactt    840

agtgatgctt gtagagccct ggaatcttta atgtttcctc ttaaatatag ttatccttat    900

atccctattc tcccggctca gctactggaa gttctaagtt ccccaacgcc tttcattatt    960

ggagtacatt ctgtctttaa aactgatgtc catgaacttt tagatgtaat catagcagat   1020

ttggatggag gcactattaa aattcccgaa tgtattcacc tctcttccct cccagaacca   1080

cttctacatc agactcaatc agctctttct ttgattttac acccagattt ggaagtagca   1140

gatcatgctt ttcctcctcc acgaacagct ttatcccact caaaaatgct ggataaagag   1200

gtgcgagccg ttttccttag attatttgca caactcttcc aaggatatag atcctgcctg   1260

caacttataa gaattcatgc agagccagta atacatttcc acaagacagc attcttgggg   1320

cagcgtggtt tggtcgagaa tgatttcctc actaaagtac tcagtggaat ggcatttgca   1380

ggttttgttt cagaaagagg tcctccttat agatcttgtg atctctttga tgagttggta   1440

gcctttgaag tagagagaat taaagttgaa gaaaataacc cagtgaagat gataaagcat   1500

gtcagggaac ttgctgagca actattcaaa aatgagaatc caaatcctca tatggcattc   1560

cagaaagttc cacggccaac agaaggatcc catttgcgag ttcatattct tcctttccca   1620

gagattaatg aagcccgggt tcaggaatta atacaggaaa atgttgctaa gaaccagaat   1680

gcacctcctg ccacacgaat agaaaagaaa tgtgttgtgc cagcaggtcc acctgttgtt   1740

tcgataatgg acaaggtgac gacagttttc aacagtgcac aaagactaga agttgtcaga   1800

aactgtatct cattcatatt tgaaaataaa attttggaaa ctgaaaagac ccttcctgct   1860

gcactcagag cccttaaagg aaaggcagca agacagtgtc tcactgatga attgggtttg   1920

catgtccagc aaaaccgggc aatattagac catcaacagt ttgactacat aataaggatg   1980

atgaattgta ctctacagga ttgttcaagt ttagaagaat acaacattgc cgcagcatta   2040

ctccctttga ccagtgcttt ctataggaaa cttgcccctg gagtcagcca gtttgcttac   2100

acgtgtgtac aagaccaccc catttggaca aatcagcaat tttgggagac aaccttttac   2160

aatgcagtgc aggaacaggt tcgctccctt tatctctcag ccaaggaaga caatcatgcc   2220

ccgcatctga agcaaaagga taagcttcct gatgaccatt atcaggagaa gacagcaatg   2280

gacctggcag ctgagcaact acgcctttgg cctaccctga gcaagtcaac tcagcaagag   2340

ctagtgcaac atgaggaaag cactgtcttt agtcaggcca ttcactttgc aaacctcatg   2400

gtgaacctgc tagttccact cgacacaagt aaaaacaagc tcctaagaac atcagcgcca   2460

ggtgactggg agagcggaag caacagcatt gtcacaaaca gtattgcagg aagtgtagct   2520

gagagctatg atacagagag tgggtttgaa gattcagaga atactgacat tgccaattct   2580

gttgtgcggt tcattacccg atttattgac aaagtttgta cagagagtgg agttactcag   2640

gatcacatca agagccttca ttgcatgata ccaggaattg tagctatgca cattgagacc   2700

ctagaagcag tacatcgaga aagcagaaga cttccgccta ttcagaagcc caagattctt   2760

agacctgctc tgctgccagg agaagaaatt gtctgtgagg gtcttcgagt cttgctggat   2820

cctgatggaa gagaagaagc tactggaggt cttcttggag gccctcagct cctgccagca   2880

gaaggagcct tgttcctcac cacatacaga attctcttca gaggaacacc ccatgatcag   2940

ttagtgggtg agcagacagt tgtgcggagc tttcccattg cctccatcac caaggagaag   3000

aagattacaa tgcagaacca gctacagcag aacatgcaag aaggactgca gatcacatca   3060

gcatcttttc agttgattaa ggtagcattt gatgaagaag tcagtccaga agtagtagag   3120

atctttaaga aacagctgat gaagttccgt tatcctcagt ccattttcag tacctttgct   3180

tttgctgctg gacaaactac cccacaaata attttaccaa aacagaagga aaagaacact   3240

tcttttcgta ccttctcaaa aacaattgtg aaaggtgcca aaagggcagg gaaaatgaca   3300

attgggcggc aatatttact gaagaagaag acagggacaa ttgtggaaga aagagtaaat   3360

cgtcctggat ggaatgaaga tgatgatgta tctgtttcag atgagagtga gctccccaca   3420

agtaccaccc tgaaggcctc cgagaagtct acaatggaac agttggtgga aaaagcttgt   3480

ttcagagact atcagcgttt aggtttagga accataagtg gcagctcttc ccgttcaaga   3540

cccgagtatt ttagaattac tgcctccaac aggatgtatt cactctgccg gagctatcct   3600

ggccttttag tcgtacctca agctgtacag gacagtagtt taccaagagt agctcgctgc   3660

tatcgacaca atcgcctgcc tgttgtatgt tggaagaact caagaagtgg tactctgctc   3720

ctccgatctg gaggattcca tgggaaggga gtcgttggtc ttttcaaatc tcagaactcc   3780

cctcaggccg ctcctacctc ctctttagaa tcttccagta gcatagaaca agagaaatac   3840

ttgcaagcct tactgaatgc tgtttctgtc catcagaaac tcagaggcaa cagcactctt   3900

actgtcaggc cagcctttgc tctatctcca ggtgtgtggg caagtcttcg ctctagcact   3960

cgcttgatca gctctccaac atccttcatt gatgttggcg cccggctggc aggcaaggat   4020

cactcggcct ccttcagtaa cagcagctac ctacaaaacc agctcttgaa acggcaagca   4080

gccctttaca tatttggtga aaagtcgcaa ctaaggaact tcaaggtaga atttgcttta   4140

aattgtgagt ttgttcctgt tgaatttcat gaaatccggc aagtgaaagc cagttttaag   4200

aagctgatga gggcttgtat cccaagcacc atccctactg actcagaagt gaccttcctg   4260

aaagcgctgg gagattctga gtggttccca cagcttcaca ggataatgca gctggctgtg   4320

gttgtatcag aagtacttga gaatggttcc tcagttttgg tctgtttgga ggaaggctgg   4380

gacatcactg cacaagtgac atccctggtt cagttactca gtgatccctt ttataggaca   4440

cttgaaggct tccagatgtt ggttgaaaaa gagtggctct cttttggtca caaattcagt   4500

cagaggagca gcttgaccct caactgtcag gggagtggtt ttgctccagt cttcttacag   4560

ttcttagact gtgtacacca ggttcacaac cagtatccaa ctgagtttga attcaatctc   4620

tattacttaa agttcttggc tttccactat gtgtctaatc gctttaaaac atttctcctg   4680

gattcagact atgaaagatt agagcacgga actttatttg atgataaagg agaaaagcat   4740

gccaaaaaag gagtctgtat ttgggaatgt attgacagaa tgcacaagag gagtcccatt   4800

ttctttaatt atttatattc accattggaa atagaggctc taaagcccaa tgtaaacgtc   4860

tctagcctca agaagtggga ttactacata gaagagaccc tgtccacagg cccttcctat   4920

gactggatga tgctaacccc caagcacttc ccctccgaag actctgacct ggctggagaa   4980

gctgggccac ggagccagag gagaacagtg tggccatgct atgatgatgt cagctgtact   5040

cagcctgatg ctctcaccag ccttttcagt gaaattgaaa aattggagca caaattgaac   5100

caagcccctg agaagtggca gcagctgtgg gaaagggtaa ccgtggacct taaagaagaa   5160

ccaagaacag atcgctccca aagacacctg tcgagatccc caggaattgt gtctaccaac   5220

ctaccttcct atcagaagag gtctctgcta catctcccag acagcagcat gggggaggaa   5280

cagaattcca gcatctcccc atccaatgga gtggagcgaa gagcagccac gctctatagc   5340

cagtatacat ccaagaatga tgaaaacagg tcctttgagg gaacacttta taaaagaggg   5400

gctttgctga aaggttggaa gccccgttgg tttgttttgg atgtaacaaa acatcagctg   5460

cgctactatg actcaggtga ggacacaagc tgtaaaggcc acattgatct ggctgaagta   5520

gaaatggtca tccctgctgg ccccagcatg ggagccccaa agcacacaag tgacaaggct   5580

ttctttgatc tcaagaccag caaacgtgtg tataacttct gcgcccagga tggacagagt   5640

gcccagcaat ggatggacaa gatccagagt tgtatctctg atgcctgatg cccatggtca   5700

acccacgcag aagaaacaga agaactcatg ctgccagata gatagaaaaa gaagcatgga   5760

tccttgagga gctgacaaca agttatccca gggcctgagg ttctcctgcc cagtcccctc   5820

ttgcaggggt tgctatatct acttaacctg aataggtgtt tcacacaggt ctggtcaaca   5880

gccccatgca ctccctgtat cttgcactaa atttttctaa cagggtctta gtggttaatg   5940

atcagaagat gtctcctgag ccaactgtga acctcaccca ggcaaaatgg ctaccaccta   6000

cttgggtcct tcttcatgaa agctatagat ccttttttgt tctctgaggt cataatttcc   6060

tcggagacct gtttaacaag caaaaatcaa aaccctccaa gattgtctca tattctacct   6120

ggactaggtt tcctatgaga gacatctact tgtaatgcct gacctttgag atgctcagtt   6180

ctctggtgct gccaaaagat gcttccatgg tccgtgctct gccagtgggg ttcacaacaa   6240

gagacgtcat tgttcagtag caggcaaaga gggagcacac agcattattc tgatggaaaa   6300

agattatcca gggaatggta caacaatgac cagcccaatg caggaaaaca ctacttccaa   6360

aacactgaat tctctagacc agaggtgctc tgaggatcca gggccttgtg ttcttatgta   6420

tcttctgctt cctgacagct tctttttcaa aataacatgc aaaaaaagct gaatgcacta   6480

actcacaaaa caaacacttg cactgaattc ccaatgaagt gaagatgttg gaaagacaga   6540

ggccagctat ttaggaccat acgcacctgt gacaagggct gtgttgacca cagtcacact   6600

gtggcatgac tggataccca aactacactt ctacacatga aaagtaagaa ctgtctttag   6660

attttcttta ctttgataac ttgtgattgt ttagcttaag acccaagaaa tgctgtttgc   6720

tcatggtaaa cagaaacagc atcttcgcta caaccactga caccagctgg cgtcataggt   6780

agctagatca ttgcatttgt tttgaaatgt taatatgtta aatactaaac taatatttca   6840

aaaatgtgta tatatgattt ctatatcctt gtttttcaga tagcctgctt ataatttaat   6900

ataaattaac tgatgcattc ataagatttc aataatgaaa tggttccctt ttaaaaaata   6960

aaaatacttt gtagattaaa aataaatcag aatttcaaat ttaaaattgt ccacacacta   7020

ggaaatagaa ctgtgttaat atataagaaa tctggggata attaagaatg aaggactttt   7080

ctatcatttc cattttataa attgccacct gtgaaaatgg tttttgcaca ttatttgtat   7140

ttttctttgt atatgaaata attttttgta ctttgtaaaa tatggagccc attgtacctt   7200

cagctatttg agactataca cagtgcttct tttgtaactg gattacttta actttcgtga   7260

aggcattaca ttgcctcaca ttcactaacc accttgaatt aaatttattt cttaagaaaa   7320

agcatccctc atttactgtg                                               7340


<210>  2737
<211>  1849
<212>  PRT
<213>  Homo sapiens

<400>  2737


Met Ala Arg Leu Ala Asp Tyr Phe Ile Val Val Gly Tyr Asp His Glu 
1               5                   10                  15      


Lys Pro Gly Ser Gly Glu Gly Leu Gly Lys Ile Ile Gln Arg Phe Pro 
            20                  25                  30          


Gln Lys Asp Trp Asp Asp Thr Pro Phe Pro Gln Gly Ile Glu Leu Phe 
        35                  40                  45              


Cys Gln Pro Gly Gly Trp Gln Leu Ser Arg Glu Arg Lys Gln Pro Thr 
    50                  55                  60                  


Phe Phe Val Val Val Leu Thr Asp Ile Asp Ser Asp Arg His Tyr Cys 
65                  70                  75                  80  


Ser Cys Leu Thr Phe Tyr Glu Ala Glu Ile Asn Leu Gln Gly Thr Lys 
                85                  90                  95      


Lys Glu Glu Ile Glu Gly Glu Ala Lys Val Ser Gly Leu Ile Gln Pro 
            100                 105                 110         


Ala Glu Val Phe Ala Pro Lys Ser Leu Val Leu Val Ser Arg Leu Tyr 
        115                 120                 125             


Tyr Pro Glu Ile Phe Arg Ala Cys Leu Gly Leu Ile Tyr Thr Val Tyr 
    130                 135                 140                 


Val Asp Ser Leu Asn Val Ser Leu Glu Ser Leu Ile Ala Asn Leu Cys 
145                 150                 155                 160 


Ala Cys Leu Val Pro Ala Ala Gly Gly Ser Gln Lys Leu Phe Ser Leu 
                165                 170                 175     


Gly Ala Gly Asp Arg Gln Leu Ile Gln Thr Pro Leu His Asp Ser Leu 
            180                 185                 190         


Pro Ile Thr Gly Thr Ser Val Ala Leu Leu Phe Gln Gln Leu Gly Ile 
        195                 200                 205             


Gln Asn Val Leu Ser Leu Phe Cys Ala Val Leu Thr Glu Asn Lys Val 
    210                 215                 220                 


Leu Phe His Ser Ala Ser Phe Gln Arg Leu Ser Asp Ala Cys Arg Ala 
225                 230                 235                 240 


Leu Glu Ser Leu Met Phe Pro Leu Lys Tyr Ser Tyr Pro Tyr Ile Pro 
                245                 250                 255     


Ile Leu Pro Ala Gln Leu Leu Glu Val Leu Ser Ser Pro Thr Pro Phe 
            260                 265                 270         


Ile Ile Gly Val His Ser Val Phe Lys Thr Asp Val His Glu Leu Leu 
        275                 280                 285             


Asp Val Ile Ile Ala Asp Leu Asp Gly Gly Thr Ile Lys Ile Pro Glu 
    290                 295                 300                 


Cys Ile His Leu Ser Ser Leu Pro Glu Pro Leu Leu His Gln Thr Gln 
305                 310                 315                 320 


Ser Ala Leu Ser Leu Ile Leu His Pro Asp Leu Glu Val Ala Asp His 
                325                 330                 335     


Ala Phe Pro Pro Pro Arg Thr Ala Leu Ser His Ser Lys Met Leu Asp 
            340                 345                 350         


Lys Glu Val Arg Ala Val Phe Leu Arg Leu Phe Ala Gln Leu Phe Gln 
        355                 360                 365             


Gly Tyr Arg Ser Cys Leu Gln Leu Ile Arg Ile His Ala Glu Pro Val 
    370                 375                 380                 


Ile His Phe His Lys Thr Ala Phe Leu Gly Gln Arg Gly Leu Val Glu 
385                 390                 395                 400 


Asn Asp Phe Leu Thr Lys Val Leu Ser Gly Met Ala Phe Ala Gly Phe 
                405                 410                 415     


Val Ser Glu Arg Gly Pro Pro Tyr Arg Ser Cys Asp Leu Phe Asp Glu 
            420                 425                 430         


Leu Val Ala Phe Glu Val Glu Arg Ile Lys Val Glu Glu Asn Asn Pro 
        435                 440                 445             


Val Lys Met Ile Lys His Val Arg Glu Leu Ala Glu Gln Leu Phe Lys 
    450                 455                 460                 


Asn Glu Asn Pro Asn Pro His Met Ala Phe Gln Lys Val Pro Arg Pro 
465                 470                 475                 480 


Thr Glu Gly Ser His Leu Arg Val His Ile Leu Pro Phe Pro Glu Ile 
                485                 490                 495     


Asn Glu Ala Arg Val Gln Glu Leu Ile Gln Glu Asn Val Ala Lys Asn 
            500                 505                 510         


Gln Asn Ala Pro Pro Ala Thr Arg Ile Glu Lys Lys Cys Val Val Pro 
        515                 520                 525             


Ala Gly Pro Pro Val Val Ser Ile Met Asp Lys Val Thr Thr Val Phe 
    530                 535                 540                 


Asn Ser Ala Gln Arg Leu Glu Val Val Arg Asn Cys Ile Ser Phe Ile 
545                 550                 555                 560 


Phe Glu Asn Lys Ile Leu Glu Thr Glu Lys Thr Leu Pro Ala Ala Leu 
                565                 570                 575     


Arg Ala Leu Lys Gly Lys Ala Ala Arg Gln Cys Leu Thr Asp Glu Leu 
            580                 585                 590         


Gly Leu His Val Gln Gln Asn Arg Ala Ile Leu Asp His Gln Gln Phe 
        595                 600                 605             


Asp Tyr Ile Ile Arg Met Met Asn Cys Thr Leu Gln Asp Cys Ser Ser 
    610                 615                 620                 


Leu Glu Glu Tyr Asn Ile Ala Ala Ala Leu Leu Pro Leu Thr Ser Ala 
625                 630                 635                 640 


Phe Tyr Arg Lys Leu Ala Pro Gly Val Ser Gln Phe Ala Tyr Thr Cys 
                645                 650                 655     


Val Gln Asp His Pro Ile Trp Thr Asn Gln Gln Phe Trp Glu Thr Thr 
            660                 665                 670         


Phe Tyr Asn Ala Val Gln Glu Gln Val Arg Ser Leu Tyr Leu Ser Ala 
        675                 680                 685             


Lys Glu Asp Asn His Ala Pro His Leu Lys Gln Lys Asp Lys Leu Pro 
    690                 695                 700                 


Asp Asp His Tyr Gln Glu Lys Thr Ala Met Asp Leu Ala Ala Glu Gln 
705                 710                 715                 720 


Leu Arg Leu Trp Pro Thr Leu Ser Lys Ser Thr Gln Gln Glu Leu Val 
                725                 730                 735     


Gln His Glu Glu Ser Thr Val Phe Ser Gln Ala Ile His Phe Ala Asn 
            740                 745                 750         


Leu Met Val Asn Leu Leu Val Pro Leu Asp Thr Ser Lys Asn Lys Leu 
        755                 760                 765             


Leu Arg Thr Ser Ala Pro Gly Asp Trp Glu Ser Gly Ser Asn Ser Ile 
    770                 775                 780                 


Val Thr Asn Ser Ile Ala Gly Ser Val Ala Glu Ser Tyr Asp Thr Glu 
785                 790                 795                 800 


Ser Gly Phe Glu Asp Ser Glu Asn Thr Asp Ile Ala Asn Ser Val Val 
                805                 810                 815     


Arg Phe Ile Thr Arg Phe Ile Asp Lys Val Cys Thr Glu Ser Gly Val 
            820                 825                 830         


Thr Gln Asp His Ile Lys Ser Leu His Cys Met Ile Pro Gly Ile Val 
        835                 840                 845             


Ala Met His Ile Glu Thr Leu Glu Ala Val His Arg Glu Ser Arg Arg 
    850                 855                 860                 


Leu Pro Pro Ile Gln Lys Pro Lys Ile Leu Arg Pro Ala Leu Leu Pro 
865                 870                 875                 880 


Gly Glu Glu Ile Val Cys Glu Gly Leu Arg Val Leu Leu Asp Pro Asp 
                885                 890                 895     


Gly Arg Glu Glu Ala Thr Gly Gly Leu Leu Gly Gly Pro Gln Leu Leu 
            900                 905                 910         


Pro Ala Glu Gly Ala Leu Phe Leu Thr Thr Tyr Arg Ile Leu Phe Arg 
        915                 920                 925             


Gly Thr Pro His Asp Gln Leu Val Gly Glu Gln Thr Val Val Arg Ser 
    930                 935                 940                 


Phe Pro Ile Ala Ser Ile Thr Lys Glu Lys Lys Ile Thr Met Gln Asn 
945                 950                 955                 960 


Gln Leu Gln Gln Asn Met Gln Glu Gly Leu Gln Ile Thr Ser Ala Ser 
                965                 970                 975     


Phe Gln Leu Ile Lys Val Ala Phe Asp Glu Glu Val Ser Pro Glu Val 
            980                 985                 990         


Val Glu Ile Phe Lys Lys Gln Leu  Met Lys Phe Arg Tyr  Pro Gln Ser 
        995                 1000                 1005             


Ile Phe  Ser Thr Phe Ala Phe  Ala Ala Gly Gln Thr  Thr Pro Gln 
    1010                 1015                 1020             


Ile Ile  Leu Pro Lys Gln Lys  Glu Lys Asn Thr Ser  Phe Arg Thr 
    1025                 1030                 1035             


Phe Ser  Lys Thr Ile Val Lys  Gly Ala Lys Arg Ala  Gly Lys Met 
    1040                 1045                 1050             


Thr Ile  Gly Arg Gln Tyr Leu  Leu Lys Lys Lys Thr  Gly Thr Ile 
    1055                 1060                 1065             


Val Glu  Glu Arg Val Asn Arg  Pro Gly Trp Asn Glu  Asp Asp Asp 
    1070                 1075                 1080             


Val Ser  Val Ser Asp Glu Ser  Glu Leu Pro Thr Ser  Thr Thr Leu 
    1085                 1090                 1095             


Lys Ala  Ser Glu Lys Ser Thr  Met Glu Gln Leu Val  Glu Lys Ala 
    1100                 1105                 1110             


Cys Phe  Arg Asp Tyr Gln Arg  Leu Gly Leu Gly Thr  Ile Ser Gly 
    1115                 1120                 1125             


Ser Ser  Ser Arg Ser Arg Pro  Glu Tyr Phe Arg Ile  Thr Ala Ser 
    1130                 1135                 1140             


Asn Arg  Met Tyr Ser Leu Cys  Arg Ser Tyr Pro Gly  Leu Leu Val 
    1145                 1150                 1155             


Val Pro  Gln Ala Val Gln Asp  Ser Ser Leu Pro Arg  Val Ala Arg 
    1160                 1165                 1170             


Cys Tyr  Arg His Asn Arg Leu  Pro Val Val Cys Trp  Lys Asn Ser 
    1175                 1180                 1185             


Arg Ser  Gly Thr Leu Leu Leu  Arg Ser Gly Gly Phe  His Gly Lys 
    1190                 1195                 1200             


Gly Val  Val Gly Leu Phe Lys  Ser Gln Asn Ser Pro  Gln Ala Ala 
    1205                 1210                 1215             


Pro Thr  Ser Ser Leu Glu Ser  Ser Ser Ser Ile Glu  Gln Glu Lys 
    1220                 1225                 1230             


Tyr Leu  Gln Ala Leu Leu Asn  Ala Val Ser Val His  Gln Lys Leu 
    1235                 1240                 1245             


Arg Gly  Asn Ser Thr Leu Thr  Val Arg Pro Ala Phe  Ala Leu Ser 
    1250                 1255                 1260             


Pro Gly  Val Trp Ala Ser Leu  Arg Ser Ser Thr Arg  Leu Ile Ser 
    1265                 1270                 1275             


Ser Pro  Thr Ser Phe Ile Asp  Val Gly Ala Arg Leu  Ala Gly Lys 
    1280                 1285                 1290             


Asp His  Ser Ala Ser Phe Ser  Asn Ser Ser Tyr Leu  Gln Asn Gln 
    1295                 1300                 1305             


Leu Leu  Lys Arg Gln Ala Ala  Leu Tyr Ile Phe Gly  Glu Lys Ser 
    1310                 1315                 1320             


Gln Leu  Arg Asn Phe Lys Val  Glu Phe Ala Leu Asn  Cys Glu Phe 
    1325                 1330                 1335             


Val Pro  Val Glu Phe His Glu  Ile Arg Gln Val Lys  Ala Ser Phe 
    1340                 1345                 1350             


Lys Lys  Leu Met Arg Ala Cys  Ile Pro Ser Thr Ile  Pro Thr Asp 
    1355                 1360                 1365             


Ser Glu  Val Thr Phe Leu Lys  Ala Leu Gly Asp Ser  Glu Trp Phe 
    1370                 1375                 1380             


Pro Gln  Leu His Arg Ile Met  Gln Leu Ala Val Val  Val Ser Glu 
    1385                 1390                 1395             


Val Leu  Glu Asn Gly Ser Ser  Val Leu Val Cys Leu  Glu Glu Gly 
    1400                 1405                 1410             


Trp Asp  Ile Thr Ala Gln Val  Thr Ser Leu Val Gln  Leu Leu Ser 
    1415                 1420                 1425             


Asp Pro  Phe Tyr Arg Thr Leu  Glu Gly Phe Gln Met  Leu Val Glu 
    1430                 1435                 1440             


Lys Glu  Trp Leu Ser Phe Gly  His Lys Phe Ser Gln  Arg Ser Ser 
    1445                 1450                 1455             


Leu Thr  Leu Asn Cys Gln Gly  Ser Gly Phe Ala Pro  Val Phe Leu 
    1460                 1465                 1470             


Gln Phe  Leu Asp Cys Val His  Gln Val His Asn Gln  Tyr Pro Thr 
    1475                 1480                 1485             


Glu Phe  Glu Phe Asn Leu Tyr  Tyr Leu Lys Phe Leu  Ala Phe His 
    1490                 1495                 1500             


Tyr Val  Ser Asn Arg Phe Lys  Thr Phe Leu Leu Asp  Ser Asp Tyr 
    1505                 1510                 1515             


Glu Arg  Leu Glu His Gly Thr  Leu Phe Asp Asp Lys  Gly Glu Lys 
    1520                 1525                 1530             


His Ala  Lys Lys Gly Val Cys  Ile Trp Glu Cys Ile  Asp Arg Met 
    1535                 1540                 1545             


His Lys  Arg Ser Pro Ile Phe  Phe Asn Tyr Leu Tyr  Ser Pro Leu 
    1550                 1555                 1560             


Glu Ile  Glu Ala Leu Lys Pro  Asn Val Asn Val Ser  Ser Leu Lys 
    1565                 1570                 1575             


Lys Trp  Asp Tyr Tyr Ile Glu  Glu Thr Leu Ser Thr  Gly Pro Ser 
    1580                 1585                 1590             


Tyr Asp  Trp Met Met Leu Thr  Pro Lys His Phe Pro  Ser Glu Asp 
    1595                 1600                 1605             


Ser Asp  Leu Ala Gly Glu Ala  Gly Pro Arg Ser Gln  Arg Arg Thr 
    1610                 1615                 1620             


Val Trp  Pro Cys Tyr Asp Asp  Val Ser Cys Thr Gln  Pro Asp Ala 
    1625                 1630                 1635             


Leu Thr  Ser Leu Phe Ser Glu  Ile Glu Lys Leu Glu  His Lys Leu 
    1640                 1645                 1650             


Asn Gln  Ala Pro Glu Lys Trp  Gln Gln Leu Trp Glu  Arg Val Thr 
    1655                 1660                 1665             


Val Asp  Leu Lys Glu Glu Pro  Arg Thr Asp Arg Ser  Gln Arg His 
    1670                 1675                 1680             


Leu Ser  Arg Ser Pro Gly Ile  Val Ser Thr Asn Leu  Pro Ser Tyr 
    1685                 1690                 1695             


Gln Lys  Arg Ser Leu Leu His  Leu Pro Asp Ser Ser  Met Gly Glu 
    1700                 1705                 1710             


Glu Gln  Asn Ser Ser Ile Ser  Pro Ser Asn Gly Val  Glu Arg Arg 
    1715                 1720                 1725             


Ala Ala  Thr Leu Tyr Ser Gln  Tyr Thr Ser Lys Asn  Asp Glu Asn 
    1730                 1735                 1740             


Arg Ser  Phe Glu Gly Thr Leu  Tyr Lys Arg Gly Ala  Leu Leu Lys 
    1745                 1750                 1755             


Gly Trp  Lys Pro Arg Trp Phe  Val Leu Asp Val Thr  Lys His Gln 
    1760                 1765                 1770             


Leu Arg  Tyr Tyr Asp Ser Gly  Glu Asp Thr Ser Cys  Lys Gly His 
    1775                 1780                 1785             


Ile Asp  Leu Ala Glu Val Glu  Met Val Ile Pro Ala  Gly Pro Ser 
    1790                 1795                 1800             


Met Gly  Ala Pro Lys His Thr  Ser Asp Lys Ala Phe  Phe Asp Leu 
    1805                 1810                 1815             


Lys Thr  Ser Lys Arg Val Tyr  Asn Phe Cys Ala Gln  Asp Gly Gln 
    1820                 1825                 1830             


Ser Ala  Gln Gln Trp Met Asp  Lys Ile Gln Ser Cys  Ile Ser Asp 
    1835                 1840                 1845             


Ala 
    

<210>  2738
<211>  7002
<212>  DNA
<213>  Homo sapiens

<400>  2738
ggttgtcaaa catggctgaa gcgctgccgc tgccgctact gccgctgcag ggaaaatgct     60

gagccctccc gggccgggtg ggcggcggcg gcgagggcgg cgacggggac ccgcttcccg    120

agcgcggcgg cggcggccat ggcccggctg gctgactact tcatcgtggt aggctatgac    180

cacgagaagc caggatcagg agaaggtctg gggaaaataa tccagagatt tccacagaag    240

gactgggatg atacaccttt tccacaggga attgagttgt tttgtcagcc tggcgggtgg    300

cagctgtcca gagagaggaa gcagccaacg ttctttgtgg ttgtcctgac agacattgac    360

tcagatcgac attactgctc atgcctaacc ttctatgagg cagagatcaa tcttcaggga    420

acaaagaagg aagagattga aggtgaagca aaagtgtctg gtttaattca gcctgcagaa    480

gtgtttgctc ccaaaagcct ggtgttggta tccagattat attatccaga aatttttagg    540

gcttgcctgg gtttgatcta taccgtgtat gtggacagcc tgaatgtctc cttggaaagt    600

ctaattgcaa acctttgtgc ctgccttgtc ccagcggctg gagggtctca gaagctgttt    660

tctttgggtg caggagatag acagttgatc cagactcctt tacatgatag tcttcctatc    720

acgggcacta gtgtggctct cctgttccag caattgggaa ttcaaaatgt cctcagcctc    780

ttttgtgcag tcctcacaga aaataaggtt ctcttccatt ctgcaagttt ccagagactt    840

agtgatgctt gtagagccct ggaatcttta atgtttcctc ttaaatatag ttatccttat    900

atccctattc tcccggctca gctactggaa gttctaagtt ccccaacgcc tttcattatt    960

ggagtacatt ctgtctttaa aactgatgtc catgaacttt tagatgtaat catagcagat   1020

ttggatggag gcactattaa aattcccgaa tgtattcacc tctcttccct cccagaacca   1080

cttctacatc agactcaatc agctctttct ttgattttac acccagattt ggaagtagca   1140

gatcatgctt ttcctcctcc acgaacagct ttatcccact caaaaatgct ggataaagag   1200

gtgcgagccg ttttccttag attatttgca caactcttcc aaggatatag atcctgcctg   1260

caacttataa gaattcatgc agagccagta atacatttcc acaagacagc attcttgggg   1320

cagcgtggtt tggtcgagaa tgatttcctc actaaagtac tcagtggaat ggcatttgca   1380

ggttttgttt cagaaagagg tcctccttat agatcttgtg atctctttga tgagttggta   1440

gcctttgaag tagagagaat taaagttgaa gaaaataacc cagtgaagat gataaagcat   1500

gtcagggaac ttgctgagca actattcaaa aatgagaatc caaatcctca tatggcattc   1560

cagaaagttc cacggccaac agaaggatcc catttgcgag ttcatattct tcctttccca   1620

gagattaatg aagcccgggt tcaggaatta atacaggaaa atgttgctaa gaaccagaat   1680

gcacctcctg ccacacgaat agaaaagaaa tgtgttgtgc cagcaggtcc acctgttgtt   1740

tcgataatgg acaaggtgac gacagttttc aacagtgcac aaagactaga agttgtcaga   1800

aactgtatct cattcatatt tgaaaataaa attttggaaa ctgaaaagac ccttcctgct   1860

gcactcagag cccttaaagg aaaggcagca agacagtgtc tcactgatga attgggtttg   1920

catgtccagc aaaaccgggc aatattagac catcaacagt ttgactacat aataaggatg   1980

atgaattgta ctctacagga ttgttcaagt ttagaagaat acaacattgc cgcagcatta   2040

ctccctttga ccagtgcttt ctataggaaa cttgcccctg gagtcagcca gtttgcttac   2100

acgtgtgtac aagaccaccc catttggaca aatcagcaat tttgggagac aaccttttac   2160

aatgcagtgc aggaacaggt tcgctccctt tatctctcag ccaaggaaga caatcatgcc   2220

ccgcatctga agcaaaagga taagcttcct gatgaccatt atcaggagaa gacagcaatg   2280

gacctggcag ctgagcaact acgcctttgg cctaccctga gcaagtcaac tcagcaagag   2340

ctagtgcaac atgaggaaag cactgtcttt agtcaggcca ttcactttgc aaacctcatg   2400

gtgaacctgc tagttccact cgacacaagt aaaaacaagc tcctaagaac atcagcgcca   2460

ggtgactggg agagcggaag caacagcatt gtcacaaaca gtattgcagg aagtgtagct   2520

gagagctatg atacagagag tgggtttgaa gattcagaga atactgacat tgccaattct   2580

gttgtgcggt tcattacccg atttattgac aaagtttgta cagagagtgg agttactcag   2640

gatcacatca agagccttca ttgcatgata ccaggaattg tagctatgca cattgagacc   2700

ctagaagcag tacatcgaga aagcagaaga cttccgccta ttcagaagcc caagattctt   2760

agacctgctc tgctgccagg agaagaaatt gtctgtgagg gtcttcgagt cttgctggat   2820

cctgatggaa gagaagaagc tactggaggt cttcttggag gccctcagct cctgccagca   2880

gaaggagcct tgttcctcac cacatacaga attctcttca gaggaacacc ccatgatcag   2940

ttagtgggtg agcagacagt tgtgcggagc tttcccattg cctccatcac caaggagaag   3000

aagattacaa tgcagaacca gctacagcag aacatgcaag aaggactgca gatcacatca   3060

gcatcttttc agttgattaa ggtagcattt gatgaagaag tcagtccaga agtagtagag   3120

atctttaaga aacagctgat gaagttccgt tatcctcagt ccattttcag tacctttgct   3180

tttgctgctg gacaaactac cccacaaata attttaccaa aacagaagga aaagaacact   3240

tcttttcgta ccttctcaaa aacaattgtg aaaggtgcca aaagggcagg gaaaatgaca   3300

attgggcggc aatatttact gaagaagaag acagggacaa ttgtggaaga aagagtaaat   3360

cgtcctggat ggaatgaaga tgatgatgta tctgtttcag atgagagtga gctccccaca   3420

agtaccaccc tgaaggcctc cgagaagtct acaatggaac agttggtgga aaaagcttgt   3480

ttcagagact atcagcgttt aggtttagga accataagtg gcagctcttc ccgttcaaga   3540

cccgagtatt ttagaattac tgcctccaac aggatgtatt cactctgccg gagctatcct   3600

ggccttttag tcgtacctca agctgtacag gacagtagtt taccaagagt agctcgctgc   3660

tatcgacaca atcgcctgcc tgttgtatgt tggaagaact caagaagtgg tactctgctc   3720

ctccgatctg gaggattcca tgggaaggga gtcgttggtc ttttcaaatc tcagaactcc   3780

cctcaggccg ctcctacctc ctctttagaa tcttccagta gcatagaaca agagaaatac   3840

ttgcaagcct tactgaatgc tgtttctgtc catcagaaac tcagaggcaa cagcactctt   3900

actgtcaggc cagcctttgc tctatctcca ggtgtgtggg caagtcttcg ctctagcact   3960

cgcttgatca gctctccaac atccttcatt gatgttggcg cccggctggc aggcaaggat   4020

cactcggcct ccttcagtaa cagcagctac ctacaaaacc agctcttgaa acggcaagca   4080

gccctttaca tatttggtga aaagtcgcaa ctaaggaact tcaaggtaga atttgcttta   4140

aattgtgagt ttgttcctgt tgaatttcat gaaatccggc aagtgaaagc cagttttaag   4200

aagctgatga gggcttgtat cccaagcacc atccctactg actcagaagt gaccttcctg   4260

aaagcgctgg gagattctga gtggttccca cagcttcaca ggataatgca gctggctgtg   4320

gttgtatcag aagtacttga gaatggttcc tcagttttgg tctgtttgga ggaaggctgg   4380

gacatcactg cacaagtgac atccctggtt cagttactca gtgatccctt ttataggaca   4440

cttgaaggct tccagatgtt ggttgaaaaa gagtggctct cttttggtca caaattcagt   4500

cagaggagca gcttgaccct caactgtcag gggagtggtt ttgctccagt cttcttacag   4560

ttcttagact gtgtacacca ggttcacaac cagtatccaa ctgagtttga attcaatctc   4620

tattacttaa agttcttggc tttccactat gtgtctaatc gctttaaaac atttctcctg   4680

gattcagact atgaaagatt agagcacgga actttatttg atgataaagg agaaaagcat   4740

gccaaaaaag gagtctgtat ttgggaatgt attgacagaa tgcacaagag gagtcccatt   4800

ttctttaatt atttatattc accattggaa atagaggctc taaagcccaa tgtaaacgtc   4860

tctagcctca agaagtggga ttactacata gaagagaccc tgtccacagg cccttcctat   4920

gactggatga tgctaacccc caagcacttc ccctccgaag actctgacct ggctggagaa   4980

gctgggccac ggagccagag gagaacagtg tggccatgct atgatgatgt cagctgtact   5040

cagcctgatg ctctcaccag ccttttcagt gaaattgaaa aattggagca caaattgaac   5100

caagcccctg agaagtggca gcagctgtgg gaaagggtaa ccgtggacct taaagaagaa   5160

ccaagaacag atcgctccca aagacacctg tcgagatccc caggaattgt gtctaccaac   5220

ctaccttcct atcagaagag gtctctgcta catctcccag acagcagcat gggggaggaa   5280

cagaattcca gcatctcccc atccaatgga gtggagcgaa gagcagccac gctctatagc   5340

cagtatacat ccaagaatga tgaaaacagg tcctttgagg gaacacttta taaaagaggg   5400

gctttgctga aaggttggaa gccccgttgg tttgttttgg atgtaacaaa acatcagctg   5460

cgctactatg actcaggtga ggacacaagc tgtaaaggcc acattgatct ggctgaagta   5520

gaaatggtca tccctgctgg ccccagcatg ggagccccaa agcacacaag tgacaaggct   5580

ttctttgatc tcaagaccag caaacgtgtg tataacttct gcgcccagga tggacagagt   5640

gcccagcaat ggatggacaa gatccagagt tgtatctctg atgcctgatg cccatggtca   5700

acccacgcag aagaaacaga agaactcatg ctgccagata gatagaaaaa gaagcatgga   5760

tccttgagga gctgacaaca agttatccca gggcctgagg ttctcctgcc cagtcccctc   5820

ttgcaggggt tgctatatct acttaacctg aataggtgtt tcacacaggt ctggtcaaca   5880

gccccatgca ctccctgtat cttgcactaa atttttctaa cagggtctta gtggttaatg   5940

atcagaagat gtctcctgag ccaactgtga acctcaccca ggcaaaatgg ctaccaccta   6000

cttgggtcct tcttcatgaa agctatagat ccttttttgt tctctgaggt cataatttcc   6060

tcggagacct gtttaacaag caaaaatcaa aaccctccaa gattgtctca tattctacct   6120

ggactaggtt tcctatgaga gacatctact tgtaatgcct gacctttgag atgctcagtt   6180

ctctggtgct gccaaaagat gcttccatgg tccgtgctct gccagtgggg ttcacaacaa   6240

gagacgtcat tgttcagtag caggcaaaga gggagcacac agcattattc tgatggaaaa   6300

agattatcca gggaatggta caacaatgac cagcccaatg caggaaaaca ctacttccaa   6360

aacactgaat tctctagacc agaggtgctc tgaggatcca gggccttgtg ttcttatgta   6420

tcttctgctt cctgacagct tctttttcaa aataacatgc aaaaaaagct gaatgcacta   6480

actcacaaaa caaacacttg cactgaattc ccaatgaagt gaagatgttg gaaagacaga   6540

ggccagctat ttaggaccat acgcacctgt gacaagggct gtgttgacca cagtcacact   6600

gtggcatgac tggataccca aactacactt ctacacatga aaagtaagaa ctgtctttag   6660

attttcttta ctttgataac ttgtgattgt ttagcttaag acccaagaaa tgctgtttgc   6720

tcatggtaaa cagaaacagc atcttcgcta caaccactga caccagctgg cgtcataggt   6780

agctagatca ttgcatttgt tttgaaatgt taatatgtta aatactaaac taatatttca   6840

aaaatgtgta tatatgattt ctatatcctt gtttttcaga tagcctgctt ataatttaat   6900

ataaattaac tgatgcattc ataagatttc aataatgaaa tggttccctt ttaaaaaata   6960

aaaatacttt gtagattaaa aataaatcag aatttcaaat tt                      7002


<210>  2739
<211>  1849
<212>  PRT
<213>  Homo sapiens

<400>  2739


Met Ala Arg Leu Ala Asp Tyr Phe Ile Val Val Gly Tyr Asp His Glu 
1               5                   10                  15      


Lys Pro Gly Ser Gly Glu Gly Leu Gly Lys Ile Ile Gln Arg Phe Pro 
            20                  25                  30          


Gln Lys Asp Trp Asp Asp Thr Pro Phe Pro Gln Gly Ile Glu Leu Phe 
        35                  40                  45              


Cys Gln Pro Gly Gly Trp Gln Leu Ser Arg Glu Arg Lys Gln Pro Thr 
    50                  55                  60                  


Phe Phe Val Val Val Leu Thr Asp Ile Asp Ser Asp Arg His Tyr Cys 
65                  70                  75                  80  


Ser Cys Leu Thr Phe Tyr Glu Ala Glu Ile Asn Leu Gln Gly Thr Lys 
                85                  90                  95      


Lys Glu Glu Ile Glu Gly Glu Ala Lys Val Ser Gly Leu Ile Gln Pro 
            100                 105                 110         


Ala Glu Val Phe Ala Pro Lys Ser Leu Val Leu Val Ser Arg Leu Tyr 
        115                 120                 125             


Tyr Pro Glu Ile Phe Arg Ala Cys Leu Gly Leu Ile Tyr Thr Val Tyr 
    130                 135                 140                 


Val Asp Ser Leu Asn Val Ser Leu Glu Ser Leu Ile Ala Asn Leu Cys 
145                 150                 155                 160 


Ala Cys Leu Val Pro Ala Ala Gly Gly Ser Gln Lys Leu Phe Ser Leu 
                165                 170                 175     


Gly Ala Gly Asp Arg Gln Leu Ile Gln Thr Pro Leu His Asp Ser Leu 
            180                 185                 190         


Pro Ile Thr Gly Thr Ser Val Ala Leu Leu Phe Gln Gln Leu Gly Ile 
        195                 200                 205             


Gln Asn Val Leu Ser Leu Phe Cys Ala Val Leu Thr Glu Asn Lys Val 
    210                 215                 220                 


Leu Phe His Ser Ala Ser Phe Gln Arg Leu Ser Asp Ala Cys Arg Ala 
225                 230                 235                 240 


Leu Glu Ser Leu Met Phe Pro Leu Lys Tyr Ser Tyr Pro Tyr Ile Pro 
                245                 250                 255     


Ile Leu Pro Ala Gln Leu Leu Glu Val Leu Ser Ser Pro Thr Pro Phe 
            260                 265                 270         


Ile Ile Gly Val His Ser Val Phe Lys Thr Asp Val His Glu Leu Leu 
        275                 280                 285             


Asp Val Ile Ile Ala Asp Leu Asp Gly Gly Thr Ile Lys Ile Pro Glu 
    290                 295                 300                 


Cys Ile His Leu Ser Ser Leu Pro Glu Pro Leu Leu His Gln Thr Gln 
305                 310                 315                 320 


Ser Ala Leu Ser Leu Ile Leu His Pro Asp Leu Glu Val Ala Asp His 
                325                 330                 335     


Ala Phe Pro Pro Pro Arg Thr Ala Leu Ser His Ser Lys Met Leu Asp 
            340                 345                 350         


Lys Glu Val Arg Ala Val Phe Leu Arg Leu Phe Ala Gln Leu Phe Gln 
        355                 360                 365             


Gly Tyr Arg Ser Cys Leu Gln Leu Ile Arg Ile His Ala Glu Pro Val 
    370                 375                 380                 


Ile His Phe His Lys Thr Ala Phe Leu Gly Gln Arg Gly Leu Val Glu 
385                 390                 395                 400 


Asn Asp Phe Leu Thr Lys Val Leu Ser Gly Met Ala Phe Ala Gly Phe 
                405                 410                 415     


Val Ser Glu Arg Gly Pro Pro Tyr Arg Ser Cys Asp Leu Phe Asp Glu 
            420                 425                 430         


Leu Val Ala Phe Glu Val Glu Arg Ile Lys Val Glu Glu Asn Asn Pro 
        435                 440                 445             


Val Lys Met Ile Lys His Val Arg Glu Leu Ala Glu Gln Leu Phe Lys 
    450                 455                 460                 


Asn Glu Asn Pro Asn Pro His Met Ala Phe Gln Lys Val Pro Arg Pro 
465                 470                 475                 480 


Thr Glu Gly Ser His Leu Arg Val His Ile Leu Pro Phe Pro Glu Ile 
                485                 490                 495     


Asn Glu Ala Arg Val Gln Glu Leu Ile Gln Glu Asn Val Ala Lys Asn 
            500                 505                 510         


Gln Asn Ala Pro Pro Ala Thr Arg Ile Glu Lys Lys Cys Val Val Pro 
        515                 520                 525             


Ala Gly Pro Pro Val Val Ser Ile Met Asp Lys Val Thr Thr Val Phe 
    530                 535                 540                 


Asn Ser Ala Gln Arg Leu Glu Val Val Arg Asn Cys Ile Ser Phe Ile 
545                 550                 555                 560 


Phe Glu Asn Lys Ile Leu Glu Thr Glu Lys Thr Leu Pro Ala Ala Leu 
                565                 570                 575     


Arg Ala Leu Lys Gly Lys Ala Ala Arg Gln Cys Leu Thr Asp Glu Leu 
            580                 585                 590         


Gly Leu His Val Gln Gln Asn Arg Ala Ile Leu Asp His Gln Gln Phe 
        595                 600                 605             


Asp Tyr Ile Ile Arg Met Met Asn Cys Thr Leu Gln Asp Cys Ser Ser 
    610                 615                 620                 


Leu Glu Glu Tyr Asn Ile Ala Ala Ala Leu Leu Pro Leu Thr Ser Ala 
625                 630                 635                 640 


Phe Tyr Arg Lys Leu Ala Pro Gly Val Ser Gln Phe Ala Tyr Thr Cys 
                645                 650                 655     


Val Gln Asp His Pro Ile Trp Thr Asn Gln Gln Phe Trp Glu Thr Thr 
            660                 665                 670         


Phe Tyr Asn Ala Val Gln Glu Gln Val Arg Ser Leu Tyr Leu Ser Ala 
        675                 680                 685             


Lys Glu Asp Asn His Ala Pro His Leu Lys Gln Lys Asp Lys Leu Pro 
    690                 695                 700                 


Asp Asp His Tyr Gln Glu Lys Thr Ala Met Asp Leu Ala Ala Glu Gln 
705                 710                 715                 720 


Leu Arg Leu Trp Pro Thr Leu Ser Lys Ser Thr Gln Gln Glu Leu Val 
                725                 730                 735     


Gln His Glu Glu Ser Thr Val Phe Ser Gln Ala Ile His Phe Ala Asn 
            740                 745                 750         


Leu Met Val Asn Leu Leu Val Pro Leu Asp Thr Ser Lys Asn Lys Leu 
        755                 760                 765             


Leu Arg Thr Ser Ala Pro Gly Asp Trp Glu Ser Gly Ser Asn Ser Ile 
    770                 775                 780                 


Val Thr Asn Ser Ile Ala Gly Ser Val Ala Glu Ser Tyr Asp Thr Glu 
785                 790                 795                 800 


Ser Gly Phe Glu Asp Ser Glu Asn Thr Asp Ile Ala Asn Ser Val Val 
                805                 810                 815     


Arg Phe Ile Thr Arg Phe Ile Asp Lys Val Cys Thr Glu Ser Gly Val 
            820                 825                 830         


Thr Gln Asp His Ile Lys Ser Leu His Cys Met Ile Pro Gly Ile Val 
        835                 840                 845             


Ala Met His Ile Glu Thr Leu Glu Ala Val His Arg Glu Ser Arg Arg 
    850                 855                 860                 


Leu Pro Pro Ile Gln Lys Pro Lys Ile Leu Arg Pro Ala Leu Leu Pro 
865                 870                 875                 880 


Gly Glu Glu Ile Val Cys Glu Gly Leu Arg Val Leu Leu Asp Pro Asp 
                885                 890                 895     


Gly Arg Glu Glu Ala Thr Gly Gly Leu Leu Gly Gly Pro Gln Leu Leu 
            900                 905                 910         


Pro Ala Glu Gly Ala Leu Phe Leu Thr Thr Tyr Arg Ile Leu Phe Arg 
        915                 920                 925             


Gly Thr Pro His Asp Gln Leu Val Gly Glu Gln Thr Val Val Arg Ser 
    930                 935                 940                 


Phe Pro Ile Ala Ser Ile Thr Lys Glu Lys Lys Ile Thr Met Gln Asn 
945                 950                 955                 960 


Gln Leu Gln Gln Asn Met Gln Glu Gly Leu Gln Ile Thr Ser Ala Ser 
                965                 970                 975     


Phe Gln Leu Ile Lys Val Ala Phe Asp Glu Glu Val Ser Pro Glu Val 
            980                 985                 990         


Val Glu Ile Phe Lys Lys Gln Leu  Met Lys Phe Arg Tyr  Pro Gln Ser 
        995                 1000                 1005             


Ile Phe  Ser Thr Phe Ala Phe  Ala Ala Gly Gln Thr  Thr Pro Gln 
    1010                 1015                 1020             


Ile Ile  Leu Pro Lys Gln Lys  Glu Lys Asn Thr Ser  Phe Arg Thr 
    1025                 1030                 1035             


Phe Ser  Lys Thr Ile Val Lys  Gly Ala Lys Arg Ala  Gly Lys Met 
    1040                 1045                 1050             


Thr Ile  Gly Arg Gln Tyr Leu  Leu Lys Lys Lys Thr  Gly Thr Ile 
    1055                 1060                 1065             


Val Glu  Glu Arg Val Asn Arg  Pro Gly Trp Asn Glu  Asp Asp Asp 
    1070                 1075                 1080             


Val Ser  Val Ser Asp Glu Ser  Glu Leu Pro Thr Ser  Thr Thr Leu 
    1085                 1090                 1095             


Lys Ala  Ser Glu Lys Ser Thr  Met Glu Gln Leu Val  Glu Lys Ala 
    1100                 1105                 1110             


Cys Phe  Arg Asp Tyr Gln Arg  Leu Gly Leu Gly Thr  Ile Ser Gly 
    1115                 1120                 1125             


Ser Ser  Ser Arg Ser Arg Pro  Glu Tyr Phe Arg Ile  Thr Ala Ser 
    1130                 1135                 1140             


Asn Arg  Met Tyr Ser Leu Cys  Arg Ser Tyr Pro Gly  Leu Leu Val 
    1145                 1150                 1155             


Val Pro  Gln Ala Val Gln Asp  Ser Ser Leu Pro Arg  Val Ala Arg 
    1160                 1165                 1170             


Cys Tyr  Arg His Asn Arg Leu  Pro Val Val Cys Trp  Lys Asn Ser 
    1175                 1180                 1185             


Arg Ser  Gly Thr Leu Leu Leu  Arg Ser Gly Gly Phe  His Gly Lys 
    1190                 1195                 1200             


Gly Val  Val Gly Leu Phe Lys  Ser Gln Asn Ser Pro  Gln Ala Ala 
    1205                 1210                 1215             


Pro Thr  Ser Ser Leu Glu Ser  Ser Ser Ser Ile Glu  Gln Glu Lys 
    1220                 1225                 1230             


Tyr Leu  Gln Ala Leu Leu Asn  Ala Val Ser Val His  Gln Lys Leu 
    1235                 1240                 1245             


Arg Gly  Asn Ser Thr Leu Thr  Val Arg Pro Ala Phe  Ala Leu Ser 
    1250                 1255                 1260             


Pro Gly  Val Trp Ala Ser Leu  Arg Ser Ser Thr Arg  Leu Ile Ser 
    1265                 1270                 1275             


Ser Pro  Thr Ser Phe Ile Asp  Val Gly Ala Arg Leu  Ala Gly Lys 
    1280                 1285                 1290             


Asp His  Ser Ala Ser Phe Ser  Asn Ser Ser Tyr Leu  Gln Asn Gln 
    1295                 1300                 1305             


Leu Leu  Lys Arg Gln Ala Ala  Leu Tyr Ile Phe Gly  Glu Lys Ser 
    1310                 1315                 1320             


Gln Leu  Arg Asn Phe Lys Val  Glu Phe Ala Leu Asn  Cys Glu Phe 
    1325                 1330                 1335             


Val Pro  Val Glu Phe His Glu  Ile Arg Gln Val Lys  Ala Ser Phe 
    1340                 1345                 1350             


Lys Lys  Leu Met Arg Ala Cys  Ile Pro Ser Thr Ile  Pro Thr Asp 
    1355                 1360                 1365             


Ser Glu  Val Thr Phe Leu Lys  Ala Leu Gly Asp Ser  Glu Trp Phe 
    1370                 1375                 1380             


Pro Gln  Leu His Arg Ile Met  Gln Leu Ala Val Val  Val Ser Glu 
    1385                 1390                 1395             


Val Leu  Glu Asn Gly Ser Ser  Val Leu Val Cys Leu  Glu Glu Gly 
    1400                 1405                 1410             


Trp Asp  Ile Thr Ala Gln Val  Thr Ser Leu Val Gln  Leu Leu Ser 
    1415                 1420                 1425             


Asp Pro  Phe Tyr Arg Thr Leu  Glu Gly Phe Gln Met  Leu Val Glu 
    1430                 1435                 1440             


Lys Glu  Trp Leu Ser Phe Gly  His Lys Phe Ser Gln  Arg Ser Ser 
    1445                 1450                 1455             


Leu Thr  Leu Asn Cys Gln Gly  Ser Gly Phe Ala Pro  Val Phe Leu 
    1460                 1465                 1470             


Gln Phe  Leu Asp Cys Val His  Gln Val His Asn Gln  Tyr Pro Thr 
    1475                 1480                 1485             


Glu Phe  Glu Phe Asn Leu Tyr  Tyr Leu Lys Phe Leu  Ala Phe His 
    1490                 1495                 1500             


Tyr Val  Ser Asn Arg Phe Lys  Thr Phe Leu Leu Asp  Ser Asp Tyr 
    1505                 1510                 1515             


Glu Arg  Leu Glu His Gly Thr  Leu Phe Asp Asp Lys  Gly Glu Lys 
    1520                 1525                 1530             


His Ala  Lys Lys Gly Val Cys  Ile Trp Glu Cys Ile  Asp Arg Met 
    1535                 1540                 1545             


His Lys  Arg Ser Pro Ile Phe  Phe Asn Tyr Leu Tyr  Ser Pro Leu 
    1550                 1555                 1560             


Glu Ile  Glu Ala Leu Lys Pro  Asn Val Asn Val Ser  Ser Leu Lys 
    1565                 1570                 1575             


Lys Trp  Asp Tyr Tyr Ile Glu  Glu Thr Leu Ser Thr  Gly Pro Ser 
    1580                 1585                 1590             


Tyr Asp  Trp Met Met Leu Thr  Pro Lys His Phe Pro  Ser Glu Asp 
    1595                 1600                 1605             


Ser Asp  Leu Ala Gly Glu Ala  Gly Pro Arg Ser Gln  Arg Arg Thr 
    1610                 1615                 1620             


Val Trp  Pro Cys Tyr Asp Asp  Val Ser Cys Thr Gln  Pro Asp Ala 
    1625                 1630                 1635             


Leu Thr  Ser Leu Phe Ser Glu  Ile Glu Lys Leu Glu  His Lys Leu 
    1640                 1645                 1650             


Asn Gln  Ala Pro Glu Lys Trp  Gln Gln Leu Trp Glu  Arg Val Thr 
    1655                 1660                 1665             


Val Asp  Leu Lys Glu Glu Pro  Arg Thr Asp Arg Ser  Gln Arg His 
    1670                 1675                 1680             


Leu Ser  Arg Ser Pro Gly Ile  Val Ser Thr Asn Leu  Pro Ser Tyr 
    1685                 1690                 1695             


Gln Lys  Arg Ser Leu Leu His  Leu Pro Asp Ser Ser  Met Gly Glu 
    1700                 1705                 1710             


Glu Gln  Asn Ser Ser Ile Ser  Pro Ser Asn Gly Val  Glu Arg Arg 
    1715                 1720                 1725             


Ala Ala  Thr Leu Tyr Ser Gln  Tyr Thr Ser Lys Asn  Asp Glu Asn 
    1730                 1735                 1740             


Arg Ser  Phe Glu Gly Thr Leu  Tyr Lys Arg Gly Ala  Leu Leu Lys 
    1745                 1750                 1755             


Gly Trp  Lys Pro Arg Trp Phe  Val Leu Asp Val Thr  Lys His Gln 
    1760                 1765                 1770             


Leu Arg  Tyr Tyr Asp Ser Gly  Glu Asp Thr Ser Cys  Lys Gly His 
    1775                 1780                 1785             


Ile Asp  Leu Ala Glu Val Glu  Met Val Ile Pro Ala  Gly Pro Ser 
    1790                 1795                 1800             


Met Gly  Ala Pro Lys His Thr  Ser Asp Lys Ala Phe  Phe Asp Leu 
    1805                 1810                 1815             


Lys Thr  Ser Lys Arg Val Tyr  Asn Phe Cys Ala Gln  Asp Gly Gln 
    1820                 1825                 1830             


Ser Ala  Gln Gln Trp Met Asp  Lys Ile Gln Ser Cys  Ile Ser Asp 
    1835                 1840                 1845             


Ala 
    

<210>  2740
<211>  6952
<212>  DNA
<213>  Homo sapiens

<400>  2740
ggttgtcaaa catggctgaa gcgctgccgc tgccgctact gccgctgcag ggaaaatgct     60

gagccctccc gggccgggtg ggcggcggcg gcgagggcgg cgacggggac ccgcttcccg    120

agcgcggcgg cggcggccat ggcccggctg gctgactact tcatcgtggt aggctatgac    180

cacgagaagc caggatcagg agaaggtctg gggaaaataa tccagagatt tccacagaag    240

gactgggatg atacaccttt tccacaggga attgagttgt tttgtcagcc tggcgggtgg    300

cagctgtcca gagagaggaa gcagccaacg ttctttgtgg ttgtcctgac agacattgac    360

tcagatcgac attactgctc atgcctaacc ttctatgagg cagagatcaa tcttcaggga    420

acaaagaagg aagagattga aggtgaagca aaagtgtctg gtttaattca gcctgcagaa    480

gtgtttgctc ccaaaagcct ggtgttggta tccagattat attatccaga aatttttagg    540

gcttgcctgg gtttgatcta taccgtgtat gtggacagcc tgaatgtctc cttggaaagt    600

ctaattgcaa acctttgtgc ctgccttgtc ccagcggctg gagggtctca gaagctgttt    660

tctttgggtg caggagatag acagttgatc cagactcctt tacatgatag tcttcctatc    720

acgggcacta gtgtggctct cctgttccag caattgggaa ttcaaaatgt cctcagcctc    780

ttttgtgcag tcctcacaga aaataaggtt ctcttccatt ctgcaagttt ccagagactt    840

agtgatgctt gtagagccct ggaatcttta atgtttcctc ttaaatatag ttatccttat    900

atccctattc tcccggctca gctactggaa gttctaagtt ccccaacgcc tttcattatt    960

ggagtacatt ctgtctttaa aactgatgtc catgaacttt tagatgtaat catagcagat   1020

ttggatggag gcactattaa aattcccgaa tgtattcacc tctcttccct cccagaacca   1080

cttctacatc agactcaatc agctctttct ttgattttac acccagattt ggaagtagca   1140

gatcatgctt ttcctcctcc acgaacagct ttatcccact caaaaatgct ggataaagag   1200

gtgcgagccg ttttccttag attatttgca caactcttcc aaggatatag atcctgcctg   1260

caacttataa gaattcatgc agagccagta atacatttcc acaagacagc attcttgggg   1320

cagcgtggtt tggtcgagaa tgatttcctc actaaagtac tcagtggaat ggcatttgca   1380

ggttttgttt cagaaagagg tcctccttat agatcttgtg atctctttga tgagttggta   1440

gcctttgaag tagagagaat taaagttgaa gaaaataacc cagtgaagat gataaagcat   1500

gtcagggaac ttgctgagca actattcaaa aatgagaatc caaatcctca tatggcattc   1560

cagaaagttc cacggccaac agaaggatcc catttgcgag ttcatattct tcctttccca   1620

gagattaatg aagcccgggt tcaggaatta atacaggaaa atgttgctaa gaaccagaat   1680

gcacctcctg ccacacgaat agaaaagaaa tgtgttgtgc cagcaggtcc acctgttgtt   1740

tcgataatgg acaaggtgac gacagttttc aacagtgcac aaagactaga agttgtcaga   1800

aactgtatct cattcatatt tgaaaataaa attttggaaa ctgaaaagac ccttcctgct   1860

gcactcagag cccttaaagg aaaggcagca agacagtgtc tcactgatga attgggtttg   1920

catgtccagc aaaaccgggc aatattagac catcaacagt ttgactacat aataaggatg   1980

atgaattgta ctctacagga ttgttcaagt ttagaagaat acaacattgc cgcagcatta   2040

ctccctttga ccagtgcttt ctataggaaa cttgcccctg gagtcagcca gtttgcttac   2100

acgtgtgtac aagaccaccc catttggaca aatcagcaat tttgggagac aaccttttac   2160

aatgcagtgc aggaacaggt tcgctccctt tatctctcag ccaaggaaga caatcatgcc   2220

ccgcatctga agcaaaagga taagcttcct gatgaccatt atcaggagaa gacagcaatg   2280

gacctggcag ctgagcaact acgcctttgg cctaccctga gcaagtcaac tcagcaagag   2340

ctagtgcaac atgaggaaag cactgtcttt agtcaggcca ttcactttgc aaacctcatg   2400

gtgaacctgc tagttccact cgacacaagt aaaaacaagc tcctaagaac atcagcgcca   2460

ggtgactggg agagcggaag caacagcatt gtcacaaaca gtattgcagg aagtgtagct   2520

gagagctatg atacagagag tgggtttgaa gattcagaga atactgacat tgccaattct   2580

gttgtgcggt tcattacccg atttattgac aaagtttgta cagagagtgg agttactcag   2640

gatcacatca agagccttca ttgcatgata ccaggaattg tagctatgca cattgagacc   2700

ctagaagcag tacatcgaga aagcagaaga cttccgccta ttcagaagcc caagattctt   2760

agacctgctc tgctgccagg agaagaaatt gtctgtgagg gtcttcgagt cttgctggat   2820

cctgatggaa gagaagaagc tactggaggt cttcttggag gccctcagct cctgccagca   2880

gaaggagcct tgttcctcac cacatacaga attctcttca gaggaacacc ccatgatcag   2940

ttagtgggtg agcagacagt tgtgcggagc tttcccattg cctccatcac caaggagaag   3000

aagattacaa tgcagaacca gctacagcag aacatgcaag aaggactgca gatcacatca   3060

gcatcttttc agttgattaa ggtagcattt gatgaagaag tcagtccaga agtagtagag   3120

atctttaaga aacagctgat gaagttccgt tatcctcagt ccattttcag tacctttgct   3180

tttgctgctg gacaaactac cccacaaata attttaccaa aacagaagga aaagaacact   3240

tcttttcgta ccttctcaaa aacaattgtg aaaggtgcca aaagggcagg gaaaatgaca   3300

attgggcggc aatatttact gaagaagaag acagggacaa ttgtggaaga aagagtaaat   3360

cgtcctggat ggaatgaaga tgatgatgta tctgtttcag atgagagtga gctccccaca   3420

agtaccaccc tgaaggcctc cgagaagtct acaatggaac agttggtgga aaaagcttgt   3480

ttcagagact atcagcgttt aggtttagga accataagtg gcagctcttc ccgttcaaga   3540

cccgagtatt ttagaattac tgcctccaac aggatgtatt cactctgccg gagctatcct   3600

ggccttttag tcgtacctca agctgtacag gacagtagtt taccaagagt agctcgctgc   3660

tatcgacaca atcgcctgcc tgttgtatgt tggaagaact caagaagtgg tactctgctc   3720

ctccgatctg gaggattcca tgggaaggga gtcgttggtc ttttcaaatc tcagaactcc   3780

cctcaggccg ctcctacctc ctctttagaa tcttccagta gcatagaaca agagaaatac   3840

ttgcaagcct tactgaatgc tgtttctgtc catcagaaac tcagaggcaa cagcactctt   3900

actgtcaggc cagcctttgc tctatctcca ggtgtgtggg caagtcttcg ctctagcact   3960

cgcttgatca gctctccaac atccttcatt gatgttggcg cccggctggc aggcaaggat   4020

cactcggcct ccttcagtaa cagcagctac ctacaaaacc agctcttgaa acggcaagca   4080

gccctttaca tatttggtga aaagtcgcaa ctaaggaact tcaaggtaga atttgcttta   4140

aattgtgagt ttgttcctgt tgaatttcat gaaatccggc aagtgaaagc cagttttaag   4200

aagctgatga gggcttgtat cccaagcacc atccctactg actcagaagt gaccttcctg   4260

aaagcgctgg gagattctga gtggttccca cagcttcaca ggataatgca gctggctgtg   4320

gttgtatcag aagtacttga gaatggttcc tcagttttgg tctgtttgga ggaaggctgg   4380

gacatcactg cacaagtgac atccctggtt cagttactca gtgatccctt ttataggaca   4440

cttgaaggct tccagatgtt ggttgaaaaa gagtggctct cttttggtca caaattcagt   4500

cagaggagca gcttgaccct caactgtcag gggagtggtt ttgctccagt cttcttacag   4560

ttcttagact gtgtacacca ggttcacaac cagtatccaa ctgagtttga attcaatctc   4620

tattacttaa agttcttggc tttccactat gtgtctaatc gctttaaaac atttctcctg   4680

gattcagact atgaaagatt agagcacgga actttatttg atgataaagg agaaaagcat   4740

gccaaaaaag gagtctgtat ttgggaatgt attgacagaa tgcacaagag gagtcccatt   4800

ttctttaatt atttatattc accattggaa atagaggctc taaagcccaa tgtaaacgtc   4860

tctagcctca agaagtggga ttactacata gaagagaccc tgtccacagg cccttcctat   4920

gactggatga tgctaacccc caagcacttc ccctccgaag actctgacct ggctggagaa   4980

gctgggccac ggagccagag gagaacagtg tggccatgct atgatgatgt cagctgtact   5040

cagcctgatg ctctcaccag ccttttcagt gaaattgaaa aattggagca caaattgaac   5100

caagcccctg agaagtggca gcagctgtgg gaaagggtaa ccgtggacct taaagaagaa   5160

ccaagaacag atcgctccca aagacacctg tcgagatccc caggaattgt gtctaccaac   5220

ctaccttcct atcagaagag gtctctgcta catctcccag acagcagcat gggggaggaa   5280

cagaattcca gcatctcccc atccaatgga gtggagcgaa gagcagccac gctctatagc   5340

cagtatacat ccaagaatga tgaaaacagg tcctttgagg gaacacttta taaaagaggg   5400

gctttgctga aaggttggaa gccccgttgg tttgttttgg atgtaacaaa acatcagctg   5460

cgctactatg actcaggtga ggacacaagc tgtaaaggcc acattgatct ggctgaagta   5520

gaaatggtca tccctgctgg ccccagcatg ggagccccaa agcacacaag tgacaaggct   5580

ttctttgatc tcaagaccag caaacgtgtg tataacttct gcgcccagga tggacagagt   5640

gcccagcaat ggatggacaa gatccagagt tgtatctctg atgcctgatg cccatggtca   5700

acccacgcag aagaaacaga agaactcatg ctgccagata gatagaaaaa gaagcatgga   5760

tccttgagga gctgacaaca agttatccca gggcctgagg ttctcctgcc cagtcccctc   5820

ttgcaggggt tgctatatct acttaacctg aataggtgtt tcacacaggt ctggtcaaca   5880

gccccatgca ctccctgtat cttgcactaa atttttctaa cagggtctta gtggttaatg   5940

atcagaagat gtctcctgag ccaactgtga acctcaccca ggcaaaatgg ctaccaccta   6000

cttgggtcct tcttcatgaa agctatagat ccttttttgt tctctgaggt cataatttcc   6060

tcggagacct gtttaacaag caaaaatcaa aaccctccaa gattgtctca tattctacct   6120

ggactaggtt tcctatgaga gacatctact tgtaatgcct gacctttgag atgctcagtt   6180

ctctggtgct gccaaaagat gcttccatgg tccgtgctct gccagtgggg ttcacaacaa   6240

gagacgtcat tgttcagtag caggcaaaga gggagcacac agcattattc tgatggaaaa   6300

agattatcca gggaatggta caacaatgac cagcccaatg caggaaaaca ctacttccaa   6360

aacactgaat tctctagacc agaggtgctc tgaggatcca gggccttgtg ttcttatgta   6420

tcttctgctt cctgacagct tctttttcaa aataacatgc aaaaaaagct gaatgcacta   6480

actcacaaaa caaacacttg cactgaattc ccaatgaagt gaagatgttg gaaagacaga   6540

ggccagctat ttaggaccat acgcacctgt gacaagggct gtgttgacca cagtcacact   6600

gtggcatgac tggataccca aactacactt ctacacatga aaagtaagaa ctgtctttag   6660

attttcttta ctttgataac ttgtgattgt ttagcttaag acccaagaaa tgctgtttgc   6720

tcatggtaaa cagaaacagc atcttcgcta caaccactga caccagctgg cgtcataggt   6780

agctagatca ttgcatttgt tttgaaatgt taatatgtta aatactaaac taatatttca   6840

aaaatgtgta tatatgattt ctatatcctt gtttttcaga tagcctgctt ataatttaat   6900

ataaattaac tgatgcattc ataagatttc aataatgaaa tggttccctt tt           6952


<210>  2741
<211>  1849
<212>  PRT
<213>  Homo sapiens

<400>  2741


Met Ala Arg Leu Ala Asp Tyr Phe Ile Val Val Gly Tyr Asp His Glu 
1               5                   10                  15      


Lys Pro Gly Ser Gly Glu Gly Leu Gly Lys Ile Ile Gln Arg Phe Pro 
            20                  25                  30          


Gln Lys Asp Trp Asp Asp Thr Pro Phe Pro Gln Gly Ile Glu Leu Phe 
        35                  40                  45              


Cys Gln Pro Gly Gly Trp Gln Leu Ser Arg Glu Arg Lys Gln Pro Thr 
    50                  55                  60                  


Phe Phe Val Val Val Leu Thr Asp Ile Asp Ser Asp Arg His Tyr Cys 
65                  70                  75                  80  


Ser Cys Leu Thr Phe Tyr Glu Ala Glu Ile Asn Leu Gln Gly Thr Lys 
                85                  90                  95      


Lys Glu Glu Ile Glu Gly Glu Ala Lys Val Ser Gly Leu Ile Gln Pro 
            100                 105                 110         


Ala Glu Val Phe Ala Pro Lys Ser Leu Val Leu Val Ser Arg Leu Tyr 
        115                 120                 125             


Tyr Pro Glu Ile Phe Arg Ala Cys Leu Gly Leu Ile Tyr Thr Val Tyr 
    130                 135                 140                 


Val Asp Ser Leu Asn Val Ser Leu Glu Ser Leu Ile Ala Asn Leu Cys 
145                 150                 155                 160 


Ala Cys Leu Val Pro Ala Ala Gly Gly Ser Gln Lys Leu Phe Ser Leu 
                165                 170                 175     


Gly Ala Gly Asp Arg Gln Leu Ile Gln Thr Pro Leu His Asp Ser Leu 
            180                 185                 190         


Pro Ile Thr Gly Thr Ser Val Ala Leu Leu Phe Gln Gln Leu Gly Ile 
        195                 200                 205             


Gln Asn Val Leu Ser Leu Phe Cys Ala Val Leu Thr Glu Asn Lys Val 
    210                 215                 220                 


Leu Phe His Ser Ala Ser Phe Gln Arg Leu Ser Asp Ala Cys Arg Ala 
225                 230                 235                 240 


Leu Glu Ser Leu Met Phe Pro Leu Lys Tyr Ser Tyr Pro Tyr Ile Pro 
                245                 250                 255     


Ile Leu Pro Ala Gln Leu Leu Glu Val Leu Ser Ser Pro Thr Pro Phe 
            260                 265                 270         


Ile Ile Gly Val His Ser Val Phe Lys Thr Asp Val His Glu Leu Leu 
        275                 280                 285             


Asp Val Ile Ile Ala Asp Leu Asp Gly Gly Thr Ile Lys Ile Pro Glu 
    290                 295                 300                 


Cys Ile His Leu Ser Ser Leu Pro Glu Pro Leu Leu His Gln Thr Gln 
305                 310                 315                 320 


Ser Ala Leu Ser Leu Ile Leu His Pro Asp Leu Glu Val Ala Asp His 
                325                 330                 335     


Ala Phe Pro Pro Pro Arg Thr Ala Leu Ser His Ser Lys Met Leu Asp 
            340                 345                 350         


Lys Glu Val Arg Ala Val Phe Leu Arg Leu Phe Ala Gln Leu Phe Gln 
        355                 360                 365             


Gly Tyr Arg Ser Cys Leu Gln Leu Ile Arg Ile His Ala Glu Pro Val 
    370                 375                 380                 


Ile His Phe His Lys Thr Ala Phe Leu Gly Gln Arg Gly Leu Val Glu 
385                 390                 395                 400 


Asn Asp Phe Leu Thr Lys Val Leu Ser Gly Met Ala Phe Ala Gly Phe 
                405                 410                 415     


Val Ser Glu Arg Gly Pro Pro Tyr Arg Ser Cys Asp Leu Phe Asp Glu 
            420                 425                 430         


Leu Val Ala Phe Glu Val Glu Arg Ile Lys Val Glu Glu Asn Asn Pro 
        435                 440                 445             


Val Lys Met Ile Lys His Val Arg Glu Leu Ala Glu Gln Leu Phe Lys 
    450                 455                 460                 


Asn Glu Asn Pro Asn Pro His Met Ala Phe Gln Lys Val Pro Arg Pro 
465                 470                 475                 480 


Thr Glu Gly Ser His Leu Arg Val His Ile Leu Pro Phe Pro Glu Ile 
                485                 490                 495     


Asn Glu Ala Arg Val Gln Glu Leu Ile Gln Glu Asn Val Ala Lys Asn 
            500                 505                 510         


Gln Asn Ala Pro Pro Ala Thr Arg Ile Glu Lys Lys Cys Val Val Pro 
        515                 520                 525             


Ala Gly Pro Pro Val Val Ser Ile Met Asp Lys Val Thr Thr Val Phe 
    530                 535                 540                 


Asn Ser Ala Gln Arg Leu Glu Val Val Arg Asn Cys Ile Ser Phe Ile 
545                 550                 555                 560 


Phe Glu Asn Lys Ile Leu Glu Thr Glu Lys Thr Leu Pro Ala Ala Leu 
                565                 570                 575     


Arg Ala Leu Lys Gly Lys Ala Ala Arg Gln Cys Leu Thr Asp Glu Leu 
            580                 585                 590         


Gly Leu His Val Gln Gln Asn Arg Ala Ile Leu Asp His Gln Gln Phe 
        595                 600                 605             


Asp Tyr Ile Ile Arg Met Met Asn Cys Thr Leu Gln Asp Cys Ser Ser 
    610                 615                 620                 


Leu Glu Glu Tyr Asn Ile Ala Ala Ala Leu Leu Pro Leu Thr Ser Ala 
625                 630                 635                 640 


Phe Tyr Arg Lys Leu Ala Pro Gly Val Ser Gln Phe Ala Tyr Thr Cys 
                645                 650                 655     


Val Gln Asp His Pro Ile Trp Thr Asn Gln Gln Phe Trp Glu Thr Thr 
            660                 665                 670         


Phe Tyr Asn Ala Val Gln Glu Gln Val Arg Ser Leu Tyr Leu Ser Ala 
        675                 680                 685             


Lys Glu Asp Asn His Ala Pro His Leu Lys Gln Lys Asp Lys Leu Pro 
    690                 695                 700                 


Asp Asp His Tyr Gln Glu Lys Thr Ala Met Asp Leu Ala Ala Glu Gln 
705                 710                 715                 720 


Leu Arg Leu Trp Pro Thr Leu Ser Lys Ser Thr Gln Gln Glu Leu Val 
                725                 730                 735     


Gln His Glu Glu Ser Thr Val Phe Ser Gln Ala Ile His Phe Ala Asn 
            740                 745                 750         


Leu Met Val Asn Leu Leu Val Pro Leu Asp Thr Ser Lys Asn Lys Leu 
        755                 760                 765             


Leu Arg Thr Ser Ala Pro Gly Asp Trp Glu Ser Gly Ser Asn Ser Ile 
    770                 775                 780                 


Val Thr Asn Ser Ile Ala Gly Ser Val Ala Glu Ser Tyr Asp Thr Glu 
785                 790                 795                 800 


Ser Gly Phe Glu Asp Ser Glu Asn Thr Asp Ile Ala Asn Ser Val Val 
                805                 810                 815     


Arg Phe Ile Thr Arg Phe Ile Asp Lys Val Cys Thr Glu Ser Gly Val 
            820                 825                 830         


Thr Gln Asp His Ile Lys Ser Leu His Cys Met Ile Pro Gly Ile Val 
        835                 840                 845             


Ala Met His Ile Glu Thr Leu Glu Ala Val His Arg Glu Ser Arg Arg 
    850                 855                 860                 


Leu Pro Pro Ile Gln Lys Pro Lys Ile Leu Arg Pro Ala Leu Leu Pro 
865                 870                 875                 880 


Gly Glu Glu Ile Val Cys Glu Gly Leu Arg Val Leu Leu Asp Pro Asp 
                885                 890                 895     


Gly Arg Glu Glu Ala Thr Gly Gly Leu Leu Gly Gly Pro Gln Leu Leu 
            900                 905                 910         


Pro Ala Glu Gly Ala Leu Phe Leu Thr Thr Tyr Arg Ile Leu Phe Arg 
        915                 920                 925             


Gly Thr Pro His Asp Gln Leu Val Gly Glu Gln Thr Val Val Arg Ser 
    930                 935                 940                 


Phe Pro Ile Ala Ser Ile Thr Lys Glu Lys Lys Ile Thr Met Gln Asn 
945                 950                 955                 960 


Gln Leu Gln Gln Asn Met Gln Glu Gly Leu Gln Ile Thr Ser Ala Ser 
                965                 970                 975     


Phe Gln Leu Ile Lys Val Ala Phe Asp Glu Glu Val Ser Pro Glu Val 
            980                 985                 990         


Val Glu Ile Phe Lys Lys Gln Leu  Met Lys Phe Arg Tyr  Pro Gln Ser 
        995                 1000                 1005             


Ile Phe  Ser Thr Phe Ala Phe  Ala Ala Gly Gln Thr  Thr Pro Gln 
    1010                 1015                 1020             


Ile Ile  Leu Pro Lys Gln Lys  Glu Lys Asn Thr Ser  Phe Arg Thr 
    1025                 1030                 1035             


Phe Ser  Lys Thr Ile Val Lys  Gly Ala Lys Arg Ala  Gly Lys Met 
    1040                 1045                 1050             


Thr Ile  Gly Arg Gln Tyr Leu  Leu Lys Lys Lys Thr  Gly Thr Ile 
    1055                 1060                 1065             


Val Glu  Glu Arg Val Asn Arg  Pro Gly Trp Asn Glu  Asp Asp Asp 
    1070                 1075                 1080             


Val Ser  Val Ser Asp Glu Ser  Glu Leu Pro Thr Ser  Thr Thr Leu 
    1085                 1090                 1095             


Lys Ala  Ser Glu Lys Ser Thr  Met Glu Gln Leu Val  Glu Lys Ala 
    1100                 1105                 1110             


Cys Phe  Arg Asp Tyr Gln Arg  Leu Gly Leu Gly Thr  Ile Ser Gly 
    1115                 1120                 1125             


Ser Ser  Ser Arg Ser Arg Pro  Glu Tyr Phe Arg Ile  Thr Ala Ser 
    1130                 1135                 1140             


Asn Arg  Met Tyr Ser Leu Cys  Arg Ser Tyr Pro Gly  Leu Leu Val 
    1145                 1150                 1155             


Val Pro  Gln Ala Val Gln Asp  Ser Ser Leu Pro Arg  Val Ala Arg 
    1160                 1165                 1170             


Cys Tyr  Arg His Asn Arg Leu  Pro Val Val Cys Trp  Lys Asn Ser 
    1175                 1180                 1185             


Arg Ser  Gly Thr Leu Leu Leu  Arg Ser Gly Gly Phe  His Gly Lys 
    1190                 1195                 1200             


Gly Val  Val Gly Leu Phe Lys  Ser Gln Asn Ser Pro  Gln Ala Ala 
    1205                 1210                 1215             


Pro Thr  Ser Ser Leu Glu Ser  Ser Ser Ser Ile Glu  Gln Glu Lys 
    1220                 1225                 1230             


Tyr Leu  Gln Ala Leu Leu Asn  Ala Val Ser Val His  Gln Lys Leu 
    1235                 1240                 1245             


Arg Gly  Asn Ser Thr Leu Thr  Val Arg Pro Ala Phe  Ala Leu Ser 
    1250                 1255                 1260             


Pro Gly  Val Trp Ala Ser Leu  Arg Ser Ser Thr Arg  Leu Ile Ser 
    1265                 1270                 1275             


Ser Pro  Thr Ser Phe Ile Asp  Val Gly Ala Arg Leu  Ala Gly Lys 
    1280                 1285                 1290             


Asp His  Ser Ala Ser Phe Ser  Asn Ser Ser Tyr Leu  Gln Asn Gln 
    1295                 1300                 1305             


Leu Leu  Lys Arg Gln Ala Ala  Leu Tyr Ile Phe Gly  Glu Lys Ser 
    1310                 1315                 1320             


Gln Leu  Arg Asn Phe Lys Val  Glu Phe Ala Leu Asn  Cys Glu Phe 
    1325                 1330                 1335             


Val Pro  Val Glu Phe His Glu  Ile Arg Gln Val Lys  Ala Ser Phe 
    1340                 1345                 1350             


Lys Lys  Leu Met Arg Ala Cys  Ile Pro Ser Thr Ile  Pro Thr Asp 
    1355                 1360                 1365             


Ser Glu  Val Thr Phe Leu Lys  Ala Leu Gly Asp Ser  Glu Trp Phe 
    1370                 1375                 1380             


Pro Gln  Leu His Arg Ile Met  Gln Leu Ala Val Val  Val Ser Glu 
    1385                 1390                 1395             


Val Leu  Glu Asn Gly Ser Ser  Val Leu Val Cys Leu  Glu Glu Gly 
    1400                 1405                 1410             


Trp Asp  Ile Thr Ala Gln Val  Thr Ser Leu Val Gln  Leu Leu Ser 
    1415                 1420                 1425             


Asp Pro  Phe Tyr Arg Thr Leu  Glu Gly Phe Gln Met  Leu Val Glu 
    1430                 1435                 1440             


Lys Glu  Trp Leu Ser Phe Gly  His Lys Phe Ser Gln  Arg Ser Ser 
    1445                 1450                 1455             


Leu Thr  Leu Asn Cys Gln Gly  Ser Gly Phe Ala Pro  Val Phe Leu 
    1460                 1465                 1470             


Gln Phe  Leu Asp Cys Val His  Gln Val His Asn Gln  Tyr Pro Thr 
    1475                 1480                 1485             


Glu Phe  Glu Phe Asn Leu Tyr  Tyr Leu Lys Phe Leu  Ala Phe His 
    1490                 1495                 1500             


Tyr Val  Ser Asn Arg Phe Lys  Thr Phe Leu Leu Asp  Ser Asp Tyr 
    1505                 1510                 1515             


Glu Arg  Leu Glu His Gly Thr  Leu Phe Asp Asp Lys  Gly Glu Lys 
    1520                 1525                 1530             


His Ala  Lys Lys Gly Val Cys  Ile Trp Glu Cys Ile  Asp Arg Met 
    1535                 1540                 1545             


His Lys  Arg Ser Pro Ile Phe  Phe Asn Tyr Leu Tyr  Ser Pro Leu 
    1550                 1555                 1560             


Glu Ile  Glu Ala Leu Lys Pro  Asn Val Asn Val Ser  Ser Leu Lys 
    1565                 1570                 1575             


Lys Trp  Asp Tyr Tyr Ile Glu  Glu Thr Leu Ser Thr  Gly Pro Ser 
    1580                 1585                 1590             


Tyr Asp  Trp Met Met Leu Thr  Pro Lys His Phe Pro  Ser Glu Asp 
    1595                 1600                 1605             


Ser Asp  Leu Ala Gly Glu Ala  Gly Pro Arg Ser Gln  Arg Arg Thr 
    1610                 1615                 1620             


Val Trp  Pro Cys Tyr Asp Asp  Val Ser Cys Thr Gln  Pro Asp Ala 
    1625                 1630                 1635             


Leu Thr  Ser Leu Phe Ser Glu  Ile Glu Lys Leu Glu  His Lys Leu 
    1640                 1645                 1650             


Asn Gln  Ala Pro Glu Lys Trp  Gln Gln Leu Trp Glu  Arg Val Thr 
    1655                 1660                 1665             


Val Asp  Leu Lys Glu Glu Pro  Arg Thr Asp Arg Ser  Gln Arg His 
    1670                 1675                 1680             


Leu Ser  Arg Ser Pro Gly Ile  Val Ser Thr Asn Leu  Pro Ser Tyr 
    1685                 1690                 1695             


Gln Lys  Arg Ser Leu Leu His  Leu Pro Asp Ser Ser  Met Gly Glu 
    1700                 1705                 1710             


Glu Gln  Asn Ser Ser Ile Ser  Pro Ser Asn Gly Val  Glu Arg Arg 
    1715                 1720                 1725             


Ala Ala  Thr Leu Tyr Ser Gln  Tyr Thr Ser Lys Asn  Asp Glu Asn 
    1730                 1735                 1740             


Arg Ser  Phe Glu Gly Thr Leu  Tyr Lys Arg Gly Ala  Leu Leu Lys 
    1745                 1750                 1755             


Gly Trp  Lys Pro Arg Trp Phe  Val Leu Asp Val Thr  Lys His Gln 
    1760                 1765                 1770             


Leu Arg  Tyr Tyr Asp Ser Gly  Glu Asp Thr Ser Cys  Lys Gly His 
    1775                 1780                 1785             


Ile Asp  Leu Ala Glu Val Glu  Met Val Ile Pro Ala  Gly Pro Ser 
    1790                 1795                 1800             


Met Gly  Ala Pro Lys His Thr  Ser Asp Lys Ala Phe  Phe Asp Leu 
    1805                 1810                 1815             


Lys Thr  Ser Lys Arg Val Tyr  Asn Phe Cys Ala Gln  Asp Gly Gln 
    1820                 1825                 1830             


Ser Ala  Gln Gln Trp Met Asp  Lys Ile Gln Ser Cys  Ile Ser Asp 
    1835                 1840                 1845             


Ala 
    

<210>  2742
<211>  521
<212>  DNA
<213>  Homo sapiens

<400>  2742
tttactggtg gctactctga cttttcaggc tcaagaaagc cacacatctt aatctgacca     60

ttatatcaat gtgtagccac tcggctacac gtaagactga gaagtcttat ggggtctttt    120

ttgctcaaag ccttcttaaa atccatcttt tatttttgag agtttaaaaa cagtcatttt    180

ttccaattct gaatttctgg ttattatttt ctttcactcc tgtaaaccaa acaatagttt    240

cctaaactca tctcttcctt gactacattt ggcaaggtaa tgcaattaca atgaacacac    300

actactaaca acttcttttc ttaaaccttc aatcttggta gaaacatgaa atggcctcca    360

agttgccaaa gatagtcatc caaaaccttg gaacaactct gaaggtccct catatggatt    420

ccttgcttcc cagctccctt tacaactgga tgtgaaaggt gctgtcttct gtactttctc    480

ttgagaggca gaaagaaata aacaatggct aattctgacc t                        521


<210>  2743
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  2743


Met Ala Ser Lys Leu Pro Lys Ile Val Ile Gln Asn Leu Gly Thr Thr 
1               5                   10                  15      


Leu Lys Val Pro His Met Asp Ser Leu Leu Pro Ser Ser Leu Tyr Asn 
            20                  25                  30          


Trp Met 
        

<210>  2744
<211>  1078
<212>  DNA
<213>  Homo sapiens

<400>  2744
gcagccccta ggagcccagc gccgccgcca tgtcctccgg ggctagcgcg agcgccctgc     60

agctcttggt agagcagctc aagttggagg ctggcgtgga gaggatcaag gtctctcagg    120

cagctgcaga gcttcaacag tactgtatgc agaatgcctg caaggatgcc ctgctggtgg    180

gtgttccagc tggaagtaac cccttccggg agcctagatc ctgtgcttta ctctgaagac    240

tcgagagaag tttgctgagg aatgccttca agcacaaagt gatgaatgac tgccttcaag    300

tctcaagaaa acacttttac ctaactttta gagatatttc agccctttcc tgtggcctgg    360

tcctatagcc aaaatcacag atattcatga gtttctactt gagtgagaaa actgggtgaa    420

ggaatagaat tttaaatagt aataactgct tgtttttttg tgcaagtact tttatacata    480

agataaacaa aaaccttacc accaaacata ccaaaatgca cctctttcat aagtgagtta    540

ctaagatttc tatacctgga atatcatgta tgtttcattt actggatgtt tacattttag    600

gaaggaaaat agttttgttt atttaaacaa ctgaatactt ataaactgtt gttcctggaa    660

gttatttatt ccataaaaaa tttgttcttt tctcatgaat ttataattcc taaatgaaga    720

ccagaaagta caaattgctg ggaggaagaa taggctttat taatcaactg atgtcttgat    780

ttttctaaat gggaagattg ctttattttt aacactaatt atgggagcag attcttagca    840

aacttctttg gaaaagttaa tgttatgatg tgcattaggc tgccccatcg tgtatataaa    900

tgaagcagat ttgatttttg tattcttacg tttctctgct ttgtagttgt ggctgtactt    960

aaagaaatac agaatttcat atatttaaaa atgtttaaaa tgtgacccac agaacattgt   1020

aaatgattaa aaactaacat gaaaatatta caacctaaaa gaattcttaa cttcaaaa     1078


<210>  2745
<211>  68
<212>  PRT
<213>  Homo sapiens

<400>  2745


Met Ser Ser Gly Ala Ser Ala Ser Ala Leu Gln Leu Leu Val Glu Gln 
1               5                   10                  15      


Leu Lys Leu Glu Ala Gly Val Glu Arg Ile Lys Val Ser Gln Ala Ala 
            20                  25                  30          


Ala Glu Leu Gln Gln Tyr Cys Met Gln Asn Ala Cys Lys Asp Ala Leu 
        35                  40                  45              


Leu Val Gly Val Pro Ala Gly Ser Asn Pro Phe Arg Glu Pro Arg Ser 
    50                  55                  60                  


Cys Ala Leu Leu 
65              

<210>  2746
<211>  557
<212>  DNA
<213>  Homo sapiens

<400>  2746
cccggctggg cgcagggcag tcaccgaagt ggcctggccg ggcgactagt ccgtctgcac     60

cgcagacagc agctattact gaacgcctgc tcggtgacca ggagcctccc cagcctaact    120

attgttcttc tcccttgtct cccatttcct tttcctttca ctttatcctc tgcgagtcaa    180

gctcttcgcg cagatccagg actggctatc agtcgctctg aggatgcgac ctacttgtcg    240

ccagcttcca cttggttccg cgccaggaca ggttttactt tcatttctcc cgcgcgcgcc    300

tccgactgct ggggaggtca aggacagcta ggcgtcggcc cacggccagg gaaggtcccg    360

tggtctggac tcgttccttc cagtctccac cagtcctggg gggtggggcg cggcgggggt    420

gttcgttctc cagagaactc tgcgactgta cctcgctgcc acctcgctgc ctcctcgctg    480

ccctttacaa aagctcgtga taattcccac ctgagagtct tggcatgcac tttatcagcc    540

tggtgcactt tgccgct                                                   557


<210>  2747
<211>  35
<212>  PRT
<213>  Homo sapiens

<400>  2747


Met Arg Pro Thr Cys Arg Gln Leu Pro Leu Gly Ser Ala Pro Gly Gln 
1               5                   10                  15      


Val Leu Leu Ser Phe Leu Pro Arg Ala Pro Pro Thr Ala Gly Glu Val 
            20                  25                  30          


Lys Asp Ser 
        35  

<210>  2748
<211>  1209
<212>  DNA
<213>  Homo sapiens

<400>  2748
gcacggccga ctggggcgcg gcgtggattc ctctaggctg gggtcaccaa cttctcaagg     60

ggcaaaggag agtcctagcc cccgcccaaa gaatttgtgc ctgttcatga tgaatcacgc    120

tagacacgtt tgtcacccgt ttgtgctctt tcatcacagc ttcttctctt tcttacttct    180

ctcctggggg ccaaactggg aaggaaaggc taagccacgg ggcttcctgc ttcgtgcttg    240

tgggtttctg gggtcctact aaccactcct ctaatcgaat gtcctgaagc ccagcgactc    300

gacggagagg ccaaaggtgc gagaccacta gccaaacagg cttctagtcc tcacctcccg    360

gcaattcgct gtgtgaaggt gggcgagtca tgtcccatct ctcgagtccc catcttagag    420

ccggtcccca gcagaccttt aagcttcctt cctactctgc catatggctc tgagctccgg    480

tgcaaaggcg gctgggcagt gggtcgcgcg gaccttgccc agagtggtct gtctgggccg    540

cgcactgctg gcttagctgc cttttcactc tcgggactca acagtggaca ttgcacctgg    600

ggaagaaatg gccgcgcgga agttatttaa ggactcttcc tggaaggagt cacctgagcg    660

gacctgaatt ccatctgagg acggaggaca gattccgggc cctgaccctg gccctggtaa    720

ggggttggga cgcggagggt tagaggagtg cagcgcggcg cactggtctg gatccggccg    780

cccggctggg cgcagggcag tcaccgaagt ggcctggccg ggcgactagt ccgtctgcac    840

cgcagacagc agctattact gaacgcctgc tcggtgacca ggagcctccc cagcctaact    900

attgttcttc tcccttgtct cccatttcct tttcctttca ctttatcctc tgcgagtcaa    960

gctcttcgcg cagatccagg actggctatc agtcgctctg aggatgcgac ctacttgtcg   1020

ccagcttcca cttggttccg cgccaggaca ggttttactt tcatttctcc cgcgcgcgcc   1080

tccgactgct ggggaggtca aggacagcta ggcgtcggcc cacggccagg gaaggtcccg   1140

tggtctggac tcgttccttc cagtctccac cagtcctggg gggtggggcg cggcgggggt   1200

cttcaaaaa                                                           1209


<210>  2749
<211>  51
<212>  PRT
<213>  Homo sapiens

<400>  2749


Met Met Asn His Ala Arg His Val Cys His Pro Phe Val Leu Phe His 
1               5                   10                  15      


His Ser Phe Phe Ser Phe Leu Leu Leu Ser Trp Gly Pro Asn Trp Glu 
            20                  25                  30          


Gly Lys Ala Lys Pro Arg Gly Phe Leu Leu Arg Ala Cys Gly Phe Leu 
        35                  40                  45              


Gly Ser Tyr 
    50      

<210>  2750
<211>  893
<212>  DNA
<213>  Homo sapiens

<400>  2750
ctttcttact tctctcctgg gggccaaact gggaaggaaa ggctaagcca cggggcttcc     60

tgcttcgtgc ttgtgggttt ctggggtcct actaaccact cctctaatcg aatgtcctga    120

agcccagcga ctcgacggag aggccaaagg tgcgagacca ctagccaaac aggcttctag    180

tcctcacctc ccggcaattc gctgtgtgaa ggtgggcgag tcatgtccca tctctcgagt    240

ccccatctta gagccggtcc ccagcagacc tttaagcttc cttcctactc tgccatatgg    300

ctctgagctc cggtgcaaag gcggctgggc agtgggtcgc gcggaccttg cccagagtgg    360

tctgtctggg ccgcgcactg ctggcttagc tgccttttca ctctcgggac tcaacagtgg    420

acattgcacc tggggaagaa atggccgcgc ggaagttatt taaggactct tcctggaagg    480

agtcacctga gcggacctga attccatctg aggacggagg acagattccg ggccctgacc    540

ctggccctgc tcttcgcgca gatccaggac tggctatcag tcgctctgag gatgcgacct    600

acttgtcgcc agcttccact tggttccgcg ccaggacagg ttttactttc atttctcccg    660

cgcgcgcctc cgactgctgg ggaggtcaag gacagctagg cgtcggccca cggccaggga    720

aggtcccgtg gtctggactc gttccttcca gtctccacca gtcctggggg gtggggcgcg    780

gcgggggtgt tcgttctcca gagaactctg cgactgtacc tcgctgccac ctcgctgcct    840

cctcgctgcc ctttacaaaa gctcgtgatt ccgtggggga aacttgagct gtg           893


<210>  2751
<211>  35
<212>  PRT
<213>  Homo sapiens

<400>  2751


Met Arg Pro Thr Cys Arg Gln Leu Pro Leu Gly Ser Ala Pro Gly Gln 
1               5                   10                  15      


Val Leu Leu Ser Phe Leu Pro Arg Ala Pro Pro Thr Ala Gly Glu Val 
            20                  25                  30          


Lys Asp Ser 
        35  

<210>  2752
<211>  2123
<212>  DNA
<213>  Homo sapiens

<400>  2752
atccgcgctg tcccttccgc gggctcttgc tgttcttcgc caggaggctt tgcactccgg     60

gccgcatggg tcctggataa ggacctcaag aggttgtagt ggcgcccctt cgctccggcg    120

tactgtctga accctgtgcc caaagagggc tgtggcagtt cctgcaccaa ccgcctggag    180

cccataccta agccctctgg gcacgaggga cctcctctcc cccgctcccc cctcccccca    240

tcccaactcc agccccaaag gaagcaatgc gcgcgtccga gagcaggagc gcgcgtggct    300

gaggaaagaa agggaaggca accgggcagc ccaggccccg ccccgccgct cccccacccg    360

tgcgcttata aagcacagga accagagctg gccactcagt ggtttcttgg tgacactgga    420

tagaacagct caagccttgc cacttcgggc ttctcactgc agctgggctt ggacttcgga    480

gttttgccat tgccagtggg acgtctgaga ctttctcctt caagtacttg gcagatcact    540

ctcttagcag ggtctgcgct tcgcagccgg gatgaagctg gtttccgtcg ccctgatgta    600

cctgggttcg ctcgccttcc taggcgctga caccgctcgg ttggatgtcg cgtcggagtt    660

tcgaaagaag tggaataagt gggctctgag tcgtgggaag agggaactgc ggatgtccag    720

cagctacccc accgggctcg ctgacgtgaa ggccgggcct gcccagaccc ttattcggcc    780

ccaggacatg aagggtgcct ctcgaagccc cgaagacagg taactacgcc ctgtgctgtc    840

cagggacggg agggaaggaa ggtgtgcggg aggagttctc tgtctccact cccctggccc    900

gggggatcgt cggggctgga ccgcagctca gatggcgcga gcagtttcca gctccctctg    960

gctctagaat ggctcccgtt cccggtgttg gggccaaagc tctgcttgat ggggtctcaa   1020

gttgcctttc ttccccctcc ccccgcccgc agcagtccgg atgccgcccg catccgagtc   1080

aagcgctacc gccagagcat gaacaacttc cagggcctcc ggagctttgg ctgccgcttc   1140

gggacgtgca cggtgcagaa gctggcacac cagatctacc agttcacaga taaggacaag   1200

gacaacgtcg cccccaggag caagatcagc ccccagggct acggccgccg gcgccggcgc   1260

tccctgcccg aggccggccc gggtcggact ctggtgtctt ctaagccaca agcacacggg   1320

gctccagccc ccccgagtgg aagtgctccc cactttcttt aggatttagg cgcccatggt   1380

acaaggaata gtcgcgcaag catcccgctg gtgcctcccg ggacgaagga cttcccgagc   1440

ggtgtgggga ccgggctctg acagccctgc ggagaccctg agtccgggag gcaccgtccg   1500

gcggcgagct ctggctttgc aagggcccct ccttctgggg gcttcgcttc cttagccttg   1560

ctcaggtgca agtgccccag ggggcggggt gcagaagaat ccgagtgttt gccaggctta   1620

aggagaggag aaactgagaa atgaatgctg agacccccgg agcaggggtc tgagccacag   1680

ccgtgctcgc ccacaaactg atttctcacg gcgtgtcacc ccaccagggc gcaagcctca   1740

ctattacttg aactttccaa aacctaaaga ggaaaagtgc aatgcgtgtt gtacatacag   1800

aggtaactat caatatttaa gtttgttgct gtcaagattt tttttgtaac ttcaaatata   1860

gagatatttt tgtacgttat atattgtatt aagggcattt taaaagcaat tatattgtcc   1920

tcccctattt taagacgtga atgtctcagc gaggtgtaaa gttgttcgcc gcgtggaatg   1980

tgagtgtgtt tgtgtgcatg aaagagaaag actgattacc tcctgtgtgg aagaaggaaa   2040

caccgagtct ctgtataatc tatttacata aaatgggtga tatgcgaaca gcaaaccaat   2100

aaactgtctc aatgctgatt cat                                           2123


<210>  2753
<211>  83
<212>  PRT
<213>  Homo sapiens

<400>  2753


Met Lys Leu Val Ser Val Ala Leu Met Tyr Leu Gly Ser Leu Ala Phe 
1               5                   10                  15      


Leu Gly Ala Asp Thr Ala Arg Leu Asp Val Ala Ser Glu Phe Arg Lys 
            20                  25                  30          


Lys Trp Asn Lys Trp Ala Leu Ser Arg Gly Lys Arg Glu Leu Arg Met 
        35                  40                  45              


Ser Ser Ser Tyr Pro Thr Gly Leu Ala Asp Val Lys Ala Gly Pro Ala 
    50                  55                  60                  


Gln Thr Leu Ile Arg Pro Gln Asp Met Lys Gly Ala Ser Arg Ser Pro 
65                  70                  75                  80  


Glu Asp Arg 
            

<210>  2754
<211>  1890
<212>  DNA
<213>  Homo sapiens

<400>  2754
atccgcgctg tcccttccgc gggctcttgc tgttcttcgc caggaggctt tgcactccgg     60

gccgcatggg tcctggataa ggacctcaag aggttgtagt ggcgcccctt cgctccggcg    120

tactgtctga accctgtgcc caaagagggc tgtggcagtt cctgcaccaa ccgcctggag    180

cccataccta agccctctgg gcacgaggga cctcctctcc cccgctcccc cctcccccca    240

tcccaactcc agccccaaag gaagcaatgc gcgcgtccga gagcaggagc gcgcgtggct    300

gaggaaagaa agggaaggca accgggcagc ccaggccccg ccccgccgct cccccacccg    360

tgcgcttata aagcacagga accagagctg gccactcagt ggtttcttgg tgacactgga    420

tagaacagct caagccttgc cacttcgggc ttctcactgc agctgggctt ggacttcgga    480

gttttgccat tgccagtggg acgtctgaga ctttctcctt caagtacttg gcagatcact    540

ctcttagcag ggtctgcgct tcgcagccgg gatgaagctg gtttccgtcg ccctgatgta    600

cctgggttcg ctcgccttcc taggcgctga caccgctcgg ttggatgtcg cgtcggagtt    660

tcgaaagaag tggaataagt gggctctgag tcgtgggaag agggaactgc ggatgtccag    720

cagctacccc accgggctcg ctgacgtgaa ggccgggcct gcccagaccc ttattcggcc    780

ccaggacatg aagggtgcct ctcgaagccc cgaagacagc agtccggatg ccgcccgcat    840

ccgagtcaag cgctaccgcc agagcatgaa caacttccag ggcctccgga gctttggctg    900

ccgcttcggg acgtgcacgg tgcagaagct ggcacaccag atctaccagt tcacagataa    960

ggacaaggac aacgtcgccc ccaggagcaa gatcagcccc cagggctacg gccgccggcg   1020

ccggcgctcc ctgcccgagg ccggcccggg tcggactctg gtgtcttcta agccacaagc   1080

acacggggct ccagcccccc cgagtggaag tgctccccac tttctttagg atttaggcgc   1140

ccatggtaca aggaatagtc gcgcaagcat cccgctggtg cctcccggga cgaaggactt   1200

cccgagcggt gtggggaccg ggctctgaca gccctgcgga gaccctgagt ccgggaggca   1260

ccgtccggcg gcgagctctg gctttgcaag ggcccctcct tctgggggct tcgcttcctt   1320

agccttgctc aggtgcaagt gccccagggg gcggggtgca gaagaatccg agtgtttgcc   1380

aggcttaagg agaggagaaa ctgagaaatg aatgctgaga cccccggagc aggggtctga   1440

gccacagccg tgctcgccca caaactgatt tctcacggcg tgtcacccca ccagggcgca   1500

agcctcacta ttacttgaac tttccaaaac ctaaagagga aaagtgcaat gcgtgttgta   1560

catacagagg taactatcaa tatttaagtt tgttgctgtc aagatttttt ttgtaacttc   1620

aaatatagag atatttttgt acgttatata ttgtattaag ggcattttaa aagcaattat   1680

attgtcctcc cctattttaa gacgtgaatg tctcagcgag gtgtaaagtt gttcgccgcg   1740

tggaatgtga gtgtgtttgt gtgcatgaaa gagaaagact gattacctcc tgtgtggaag   1800

aaggaaacac cgagtctctg tataatctat ttacataaaa tgggtgatat gcgaacagca   1860

aaccaataaa ctgtctcaat gctgattcat                                    1890


<210>  2755
<211>  185
<212>  PRT
<213>  Homo sapiens

<400>  2755


Met Lys Leu Val Ser Val Ala Leu Met Tyr Leu Gly Ser Leu Ala Phe 
1               5                   10                  15      


Leu Gly Ala Asp Thr Ala Arg Leu Asp Val Ala Ser Glu Phe Arg Lys 
            20                  25                  30          


Lys Trp Asn Lys Trp Ala Leu Ser Arg Gly Lys Arg Glu Leu Arg Met 
        35                  40                  45              


Ser Ser Ser Tyr Pro Thr Gly Leu Ala Asp Val Lys Ala Gly Pro Ala 
    50                  55                  60                  


Gln Thr Leu Ile Arg Pro Gln Asp Met Lys Gly Ala Ser Arg Ser Pro 
65                  70                  75                  80  


Glu Asp Ser Ser Pro Asp Ala Ala Arg Ile Arg Val Lys Arg Tyr Arg 
                85                  90                  95      


Gln Ser Met Asn Asn Phe Gln Gly Leu Arg Ser Phe Gly Cys Arg Phe 
            100                 105                 110         


Gly Thr Cys Thr Val Gln Lys Leu Ala His Gln Ile Tyr Gln Phe Thr 
        115                 120                 125             


Asp Lys Asp Lys Asp Asn Val Ala Pro Arg Ser Lys Ile Ser Pro Gln 
    130                 135                 140                 


Gly Tyr Gly Arg Arg Arg Arg Arg Ser Leu Pro Glu Ala Gly Pro Gly 
145                 150                 155                 160 


Arg Thr Leu Val Ser Ser Lys Pro Gln Ala His Gly Ala Pro Ala Pro 
                165                 170                 175     


Pro Ser Gly Ser Ala Pro His Phe Leu 
            180                 185 

<210>  2756
<211>  1769
<212>  DNA
<213>  Homo sapiens

<400>  2756
atccgcgctg tcccttccgc gggctcttgc tgttcttcgc caggaggctt tgcactccgg     60

gccgcatggg tcctggataa ggacctcaag aggttgtagt ggcgcccctt cgctccggcg    120

tactgtctga accctgtgcc caaagagggc tgtggcagtt cctgcaccaa ccgcctggag    180

cccataccta agccctctgg gcacgaggga cctcctctcc cccgctcccc cctcccccca    240

tcccaactcc agccccaaag gaagcaatgc gcgcgtccga gagcaggagc gcgcgtggct    300

gaggaaagaa agggaaggca accgggcagc ccaggccccg ccccgccgct cccccacccg    360

tgcgcttata aagcacagga accagagctg gccactcagt ggtttcttgg tgacactgga    420

tagaacagct caagccttgc cacttcgggc ttctcactgc agctgggctt ggacttcgga    480

gttttgccat tgccagtggg acgtctgaga ctttctcctt caagtacttg gcagatcact    540

ctcttagcag ggtctgcgct tcgcagccgg gatgaagctg gtttccgtcg ccctgatgta    600

cctgggttcg ctcgccttcc taggcgctga caccgctcgg ttggatgtcg cgtcggagtt    660

tcgaaagaag tggaataagt gggctctgag tcgtgggaag agggaactgc ggatgtccag    720

cagctacccc accgggctcg ctgacgtgaa ggccgggcct gcccagaccc ttattcggcc    780

ccaggacatg aagggtgcct ctcgaagccc cgaagacagc agtccggatg ccgcccgcat    840

ccgagtcaag cgctaccgcc agagcatgaa caacttccag ggcctccgga gctttggctg    900

ccgcttcggg acgtgcacgg tgcagaagct ggcacaccag atctaccagt tcacagataa    960

ggacaaggac aacgtcgccc ccaggagcaa gatcagcccc cagggctacg gccgccggcg   1020

ccggcgctcc ctgcccgagg ccggcccggg tcggactctg gtgtcttcta agccacaagc   1080

acacggggct ccagcccccc cgagtggaag tgctccccac tttctttagg atttaggcac   1140

cgtccggcgg cgagctctgg ctttgcaagg gcccctcctt ctgggggctt cgcttcctta   1200

gccttgctca ggtgcaagtg ccccaggggg cggggtgcag aagaatccga gtgtttgcca   1260

ggcttaagga gaggagaaac tgagaaatga atgctgagac ccccggagca ggggtctgag   1320

ccacagccgt gctcgcccac aaactgattt ctcacggcgt gtcaccccac cagggcgcaa   1380

gcctcactat tacttgaact ttccaaaacc taaagaggaa aagtgcaatg cgtgttgtac   1440

atacagaggt aactatcaat atttaagttt gttgctgtca agattttttt tgtaacttca   1500

aatatagaga tatttttgta cgttatatat tgtattaagg gcattttaaa agcaattata   1560

ttgtcctccc ctattttaag acgtgaatgt ctcagcgagg tgtaaagttg ttcgccgcgt   1620

ggaatgtgag tgtgtttgtg tgcatgaaag agaaagactg attacctcct gtgtggaaga   1680

aggaaacacc gagtctctgt ataatctatt tacataaaat gggtgatatg cgaacagcaa   1740

accaataaac tgtctcaatg ctgattcat                                     1769


<210>  2757
<211>  185
<212>  PRT
<213>  Homo sapiens

<400>  2757


Met Lys Leu Val Ser Val Ala Leu Met Tyr Leu Gly Ser Leu Ala Phe 
1               5                   10                  15      


Leu Gly Ala Asp Thr Ala Arg Leu Asp Val Ala Ser Glu Phe Arg Lys 
            20                  25                  30          


Lys Trp Asn Lys Trp Ala Leu Ser Arg Gly Lys Arg Glu Leu Arg Met 
        35                  40                  45              


Ser Ser Ser Tyr Pro Thr Gly Leu Ala Asp Val Lys Ala Gly Pro Ala 
    50                  55                  60                  


Gln Thr Leu Ile Arg Pro Gln Asp Met Lys Gly Ala Ser Arg Ser Pro 
65                  70                  75                  80  


Glu Asp Ser Ser Pro Asp Ala Ala Arg Ile Arg Val Lys Arg Tyr Arg 
                85                  90                  95      


Gln Ser Met Asn Asn Phe Gln Gly Leu Arg Ser Phe Gly Cys Arg Phe 
            100                 105                 110         


Gly Thr Cys Thr Val Gln Lys Leu Ala His Gln Ile Tyr Gln Phe Thr 
        115                 120                 125             


Asp Lys Asp Lys Asp Asn Val Ala Pro Arg Ser Lys Ile Ser Pro Gln 
    130                 135                 140                 


Gly Tyr Gly Arg Arg Arg Arg Arg Ser Leu Pro Glu Ala Gly Pro Gly 
145                 150                 155                 160 


Arg Thr Leu Val Ser Ser Lys Pro Gln Ala His Gly Ala Pro Ala Pro 
                165                 170                 175     


Pro Ser Gly Ser Ala Pro His Phe Leu 
            180                 185 

<210>  2758
<211>  2034
<212>  DNA
<213>  Homo sapiens

<400>  2758
agaaagggaa ggcaaccggg cagcccaggc cccgccccgc cgctccccca cccgtgcgct     60

tataaagcac aggaaccaga gctggccact cagtggtttc ttggtgacac tggatagaac    120

agctcaagcc ttgccacttc gggcttctca ctgcagctgg gcttggactt cggagttttg    180

ccattgccag tgggacgtct gagactttct ccttcaagta cttggcagat cactctctta    240

gcaggtaggt gccgcagacc ctgcgggtta agaggtgggg tggggggcag tgcttgccaa    300

ggccctaaac tgggagcgct gggtgagggg aacaacccac tttggagggt tctctgagag    360

atagatacac cccatatcct gggcccagct cgtgcacaca gctggaggtc cagagaccca    420

gtcccctctg ctccgtcagc caagttccaa gaagttgagc agagaccctc tgggagcctg    480

gcggggtgca gcggcctccc ctgcggggcc tgtcacccgg ccggcgcgtg caaacgcctc    540

tggcgcctct ctgcgcggag ggagataagc gtctgagcca gggaaagcgc gggctaaacc    600

cgcctcgccg gggcccctgc ccgccctccg tgccccgccc gggcggtgca gctggcccgg    660

gtgctcacgc tcgactctct ttcttctttt ccagggtctg cgcttcgcag ccgggatgaa    720

gctggtttcc gtcgccctga tgtacctggg ttcgctcgcc ttcctaggcg ctgacaccgc    780

tcggttggat gtcgcgtcgg agtttcgaaa gaagtggaat aagtgggctc tgagtcgtgg    840

gaagagggaa ctgcggatgt ccagcagcta ccccaccggg ctcgctgacg tgaaggccgg    900

gcctgcccag acccttattc ggccccagga catgaagggt gcctctcgaa gccccgaaga    960

cagcagtccg gatgccgccc gcatccgagt caagcgctac cgccagagca tgaacaactt   1020

ccagggcctc cggagctttg gctgccgctt cgggacgtgc acggtgcaga agctggcaca   1080

ccagatctac cagttcacag ataaggacaa ggacaacgtc gcccccagga gcaagatcag   1140

cccccagggc tacggccgcc ggcgccggcg ctccctgccc gaggccggcc cgggtcggac   1200

tctggtgtct tctaagccac aagcacacgg ggctccagcc cccccgagtg gaagtgctcc   1260

ccactttctt taggatttag gcgcccatgg tacaaggaat agtcgcgcaa gcatcccgct   1320

ggtgcctccc gggacgaagg acttcccgag cggtgtgggg accgggctct gacagccctg   1380

cggagaccct gagtccggga ggcaccgtcc ggcggcgagc tctggctttg caagggcccc   1440

tccttctggg ggcttcgctt ccttagcctt gctcaggtgc aagtgcccca gggggcgggg   1500

tgcagaagaa tccgagtgtt tgccaggctt aaggagagga gaaactgaga aatgaatgct   1560

gagacccccg gagcaggggt ctgagccaca gccgtgctcg cccacaaact gatttctcac   1620

ggcgtgtcac cccaccaggg cgcaagcctc actattactt gaactttcca aaacctaaag   1680

aggaaaagtg caatgcgtgt tgtacataca gaggtaacta tcaatattta agtttgttgc   1740

tgtcaagatt ttttttgtaa cttcaaatat agagatattt ttgtacgtta tatattgtat   1800

taagggcatt ttaaaagcaa ttatattgtc ctcccctatt ttaagacgtg aatgtctcag   1860

cgaggtgtaa agttgttcgc cgcgtggaat gtgagtgtgt ttgtgtgcat gaaagagaaa   1920

gactgattac ctcctgtgtg gaagaaggaa acaccgagtc tctgtataat ctatttacat   1980

aaaatgggtg atatgcgaac agcaaaccaa taaactgtct caatgctgat tcat         2034


<210>  2759
<211>  185
<212>  PRT
<213>  Homo sapiens

<400>  2759


Met Lys Leu Val Ser Val Ala Leu Met Tyr Leu Gly Ser Leu Ala Phe 
1               5                   10                  15      


Leu Gly Ala Asp Thr Ala Arg Leu Asp Val Ala Ser Glu Phe Arg Lys 
            20                  25                  30          


Lys Trp Asn Lys Trp Ala Leu Ser Arg Gly Lys Arg Glu Leu Arg Met 
        35                  40                  45              


Ser Ser Ser Tyr Pro Thr Gly Leu Ala Asp Val Lys Ala Gly Pro Ala 
    50                  55                  60                  


Gln Thr Leu Ile Arg Pro Gln Asp Met Lys Gly Ala Ser Arg Ser Pro 
65                  70                  75                  80  


Glu Asp Ser Ser Pro Asp Ala Ala Arg Ile Arg Val Lys Arg Tyr Arg 
                85                  90                  95      


Gln Ser Met Asn Asn Phe Gln Gly Leu Arg Ser Phe Gly Cys Arg Phe 
            100                 105                 110         


Gly Thr Cys Thr Val Gln Lys Leu Ala His Gln Ile Tyr Gln Phe Thr 
        115                 120                 125             


Asp Lys Asp Lys Asp Asn Val Ala Pro Arg Ser Lys Ile Ser Pro Gln 
    130                 135                 140                 


Gly Tyr Gly Arg Arg Arg Arg Arg Ser Leu Pro Glu Ala Gly Pro Gly 
145                 150                 155                 160 


Arg Thr Leu Val Ser Ser Lys Pro Gln Ala His Gly Ala Pro Ala Pro 
                165                 170                 175     


Pro Ser Gly Ser Ala Pro His Phe Leu 
            180                 185 

<210>  2760
<211>  1734
<212>  DNA
<213>  Homo sapiens

<400>  2760
agaaagggaa ggcaaccggg cagcccaggc cccgccccgc cgctccccca cccgtgcgct     60

tataaagcac aggaaccaga gctggccact cagtggtttc ttggtgacac tggatagaac    120

agctcaagcc ttgccacttc gggcttctca ctgcagctgg gcttggactt cggagttttg    180

ccattgccag tgggacgtct gagactttct ccttcaagta cttggcagat cactctctta    240

gcagggtctg cgcttcgcag ccgggatgaa gctggtttcc gtcgccctga tgtacctggg    300

ttcgctcgcc ttcctaggcg ctgacaccgc tcggttggat gtcgcgtcgg agtttcgaaa    360

gaagtgagtc cgggcagcgc cttccccctt gctggtacct ggcaggcaag gggaactgac    420

cgttggtccc gaaggtctag aagtgaatgg gagcagggac aggcctgggc gtcacctgaa    480

cgcacgcgaa tcgggtctgc ttgtgttttc caggtggaat aagtgggctc tgagtcgtgg    540

gaagagggaa ctgcggatgt ccagcagcta ccccaccggg ctcgctgacg tgaaggccgg    600

gcctgcccag acccttattc ggccccagga catgaagggt gcctctcgaa gccccgaaga    660

cagcagtccg gatgccgccc gcatccgagt caagcgctac cgccagagca tgaacaactt    720

ccagggcctc cggagctttg gctgccgctt cgggacgtgc acggtgcaga agctggcaca    780

ccagatctac cagttcacag ataaggacaa ggacaacgtc gcccccagga gcaagatcag    840

cccccagggc tacggccgcc ggcgccggcg ctccctgccc gaggccggcc cgggtcggac    900

tctggtgtct tctaagccac aagcacacgg ggctccagcc cccccgagtg gaagtgctcc    960

ccactttctt taggatttag gcgcccatgg tacaaggaat agtcgcgcaa gcatcccgct   1020

ggtgcctccc gggacgaagg acttcccgag cggtgtgggg accgggctct gacagccctg   1080

cggagaccct gagtccggga ggcaccgtcc ggcggcgagc tctggctttg caagggcccc   1140

tccttctggg ggcttcgctt ccttagcctt gctcaggtgc aagtgcccca gggggcgggg   1200

tgcagaagaa tccgagtgtt tgccaggctt aaggagagga gaaactgaga aatgaatgct   1260

gagacccccg gagcaggggt ctgagccaca gccgtgctcg cccacaaact gatttctcac   1320

ggcgtgtcac cccaccaggg cgcaagcctc actattactt gaactttcca aaacctaaag   1380

aggaaaagtg caatgcgtgt tgtacataca gaggtaacta tcaatattta agtttgttgc   1440

tgtcaagatt ttttttgtaa cttcaaatat agagatattt ttgtacgtta tatattgtat   1500

taagggcatt ttaaaagcaa ttatattgtc ctcccctatt ttaagacgtg aatgtctcag   1560

cgaggtgtaa agttgttcgc cgcgtggaat gtgagtgtgt ttgtgtgcat gaaagagaaa   1620

gactgattac ctcctgtgtg gaagaaggaa acaccgagtc tctgtataat ctatttacat   1680

aaaatgggtg atatgcgaac agcaaaccaa taaactgtct caatgctgat tcat         1734


<210>  2761
<211>  138
<212>  PRT
<213>  Homo sapiens

<400>  2761


Met Ser Ser Ser Tyr Pro Thr Gly Leu Ala Asp Val Lys Ala Gly Pro 
1               5                   10                  15      


Ala Gln Thr Leu Ile Arg Pro Gln Asp Met Lys Gly Ala Ser Arg Ser 
            20                  25                  30          


Pro Glu Asp Ser Ser Pro Asp Ala Ala Arg Ile Arg Val Lys Arg Tyr 
        35                  40                  45              


Arg Gln Ser Met Asn Asn Phe Gln Gly Leu Arg Ser Phe Gly Cys Arg 
    50                  55                  60                  


Phe Gly Thr Cys Thr Val Gln Lys Leu Ala His Gln Ile Tyr Gln Phe 
65                  70                  75                  80  


Thr Asp Lys Asp Lys Asp Asn Val Ala Pro Arg Ser Lys Ile Ser Pro 
                85                  90                  95      


Gln Gly Tyr Gly Arg Arg Arg Arg Arg Ser Leu Pro Glu Ala Gly Pro 
            100                 105                 110         


Gly Arg Thr Leu Val Ser Ser Lys Pro Gln Ala His Gly Ala Pro Ala 
        115                 120                 125             


Pro Pro Ser Gly Ser Ala Pro His Phe Leu 
    130                 135             

<210>  2762
<211>  1967
<212>  DNA
<213>  Homo sapiens

<400>  2762
agaaagggaa ggcaaccggg cagcccaggc cccgccccgc cgctccccca cccgtgcgct     60

tataaagcac aggaaccaga gctggccact cagtggtttc ttggtgacac tggatagaac    120

agctcaagcc ttgccacttc gggcttctca ctgcagctgg gcttggactt cggagttttg    180

ccattgccag tgggacgtct gagactttct ccttcaagta cttggcagat cactctctta    240

gcagggtctg cgcttcgcag ccgggatgaa gctggtttcc gtcgccctga tgtacctggg    300

ttcgctcgcc ttcctaggcg ctgacaccgc tcggttggat gtcgcgtcgg agtttcgaaa    360

gaagtgagtc cgggcagcgc cttccccctt gctggtacct ggcaggcaag gggaactgac    420

cgttggtccc gaaggtctag aagtgaatgg gagcagggac aggcctgggc gtcacctgaa    480

cgcacgcgaa tcgggtctgc ttgtgttttc caggtggaat aagtgggctc tgagtcgtgg    540

gaagagggaa ctgcggatgt ccagcagcta ccccaccggg ctcgctgacg tgaaggccgg    600

gcctgcccag acccttattc ggccccagga catgaagggt gcctctcgaa gccccgaaga    660

caggtaacta cgccctgtgc tgtccaggga cgggagggaa ggaaggtgtg cgggaggagt    720

tctctgtctc cactcccctg gcccggggga tcgtcggggc tggaccgcag ctcagatggc    780

gcgagcagtt tccagctccc tctggctcta gaatggctcc cgttcccggt gttggggcca    840

aagctctgct tgatggggtc tcaagttgcc tttcttcccc ctccccccgc ccgcagcagt    900

ccggatgccg cccgcatccg agtcaagcgc taccgccaga gcatgaacaa cttccagggc    960

ctccggagct ttggctgccg cttcgggacg tgcacggtgc agaagctggc acaccagatc   1020

taccagttca cagataagga caaggacaac gtcgccccca ggagcaagat cagcccccag   1080

ggctacggcc gccggcgccg gcgctccctg cccgaggccg gcccgggtcg gactctggtg   1140

tcttctaagc cacaagcaca cggggctcca gcccccccga gtggaagtgc tccccacttt   1200

ctttaggatt taggcgccca tggtacaagg aatagtcgcg caagcatccc gctggtgcct   1260

cccgggacga aggacttccc gagcggtgtg gggaccgggc tctgacagcc ctgcggagac   1320

cctgagtccg ggaggcaccg tccggcggcg agctctggct ttgcaagggc ccctccttct   1380

gggggcttcg cttccttagc cttgctcagg tgcaagtgcc ccagggggcg gggtgcagaa   1440

gaatccgagt gtttgccagg cttaaggaga ggagaaactg agaaatgaat gctgagaccc   1500

ccggagcagg ggtctgagcc acagccgtgc tcgcccacaa actgatttct cacggcgtgt   1560

caccccacca gggcgcaagc ctcactatta cttgaacttt ccaaaaccta aagaggaaaa   1620

gtgcaatgcg tgttgtacat acagaggtaa ctatcaatat ttaagtttgt tgctgtcaag   1680

attttttttg taacttcaaa tatagagata tttttgtacg ttatatattg tattaagggc   1740

attttaaaag caattatatt gtcctcccct attttaagac gtgaatgtct cagcgaggtg   1800

taaagttgtt cgccgcgtgg aatgtgagtg tgtttgtgtg catgaaagag aaagactgat   1860

tacctcctgt gtggaagaag gaaacaccga gtctctgtat aatctattta cataaaatgg   1920

gtgatatgcg aacagcaaac caataaactg tctcaatgct gattcat                 1967


<210>  2763
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  2763


Met Gly Ser Gln Val Ala Phe Leu Pro Pro Pro Pro Ala Arg Ser Ser 
1               5                   10                  15      


Pro Asp Ala Ala Arg Ile Arg Val Lys Arg Tyr Arg Gln Ser Met Asn 
            20                  25                  30          


Asn Phe Gln Gly Leu Arg Ser Phe Gly Cys Arg Phe Gly Thr Cys Thr 
        35                  40                  45              


Val Gln Lys Leu Ala His Gln Ile Tyr Gln Phe Thr Asp Lys Asp Lys 
    50                  55                  60                  


Asp Asn Val Ala Pro Arg Ser Lys Ile Ser Pro Gln Gly Tyr Gly Arg 
65                  70                  75                  80  


Arg Arg Arg Arg Ser Leu Pro Glu Ala Gly Pro Gly Arg Thr Leu Val 
                85                  90                  95      


Ser Ser Lys Pro Gln Ala His Gly Ala Pro Ala Pro Pro Ser Gly Ser 
            100                 105                 110         


Ala Pro His Phe Leu 
        115         

<210>  2764
<211>  1236
<212>  DNA
<213>  Homo sapiens

<400>  2764
cataggtcct gagtgagtcc ccctggccca ccccattcag ctgagatctg acaacatatg     60

tttggggaca aacagcccca gcagccagga gcaggccaca tcatacatag tcagcatcag    120

ccatggtccc ctcccactct cctgggggaa aaaggtgctt tacaggcagc gtggcatccg    180

agcatcccca tggcgatgct gaggtcagac ctcactgtgg tgatctcacg ctggggccac    240

cggactcagg ccaggctggg agtaggctgt ctagccattg ctggctgtca ttgtcaccaa    300

gggaagggga gaagctgtga agagttgctc tggaaaaaac aaatctgctc ataggacaat    360

gggtctgggt gaacctatcc cggccctctt ggctgctggg ccagggcctg gtttttcaca    420

gggcaccatt gagaccacag gaagtggctt cctgcctctg aagacagcac acaactgccc    480

tagaaagcgc tcttgtcacc cctgctgctg gagtgcaatt gcacaatctc ggctcattgc    540

aagctccgcc tcccaggttc aagtgattct cctgcctcag cctccctagt tgctaagact    600

acagggtaga gaatcagagg cttgtagatg tctttgccac ttccacggga tctctgggag    660

ctggaaactg agctttaaga aataactata gtgcaaaggg aactaaggga aaagggttca    720

gcccaaagca gaagggactg tgatgatcac agtgacctcc tgaggccagc atggtggtag    780

cagccagaga cagcagctga gtgagaccct aagggaggga tgagccaggc agtgtgtggt    840

tggagttctc cctacacatc tcgttttcct cacctccaga tcacacacat gcacacacac    900

atatgcaccc acacacccct tacacactcc ggcccgaagg tttctgcagg actccttcct    960

ggcactctct ccagtgctgc cagcgtcgca ccacactgca aggctttgca aactttcctt   1020

ccaaagtgaa ggagaccctc tggccatctg aggctcggtc tgaagcaaca gcctcagagc   1080

gcaatctcag gcatgcagga agtgcaggaa ggccacgtgc cacatacgtt atctcactta   1140

atctcattag caggaaatgt ctttaaagtc ttatgttggt gcttaaaaat tcctgagcag   1200

tttagccctt aataaagcca ggctttttaa aatttg                             1236


<210>  2765
<211>  76
<212>  PRT
<213>  Homo sapiens

<400>  2765


Met Gly Leu Gly Glu Pro Ile Pro Ala Leu Leu Ala Ala Gly Pro Gly 
1               5                   10                  15      


Pro Gly Phe Ser Gln Gly Thr Ile Glu Thr Thr Gly Ser Gly Phe Leu 
            20                  25                  30          


Pro Leu Lys Thr Ala His Asn Cys Pro Arg Lys Arg Ser Cys His Pro 
        35                  40                  45              


Cys Cys Trp Ser Ala Ile Ala Gln Ser Arg Leu Ile Ala Ser Ser Ala 
    50                  55                  60                  


Ser Gln Val Gln Val Ile Leu Leu Pro Gln Pro Pro 
65                  70                  75      

<210>  2766
<211>  3555
<212>  DNA
<213>  Homo sapiens

<400>  2766
atggggagag aggatgagga gatagcactg cccaccgcgc gtactgcccc gccctccact     60

cttctccctc gcaaccgact ctcccttcaa acgggaaaca agatggcggc tgcaggtccg    120

agtactcggg cctcttccgc ggcggcagca gccgctctga gtcggcgggg ccggcggggc    180

cgctgtgacg agacggcggc agctaagact ggggccccag gcccggcttc tggaccttcg    240

ctgttggtgt tgtcgccgcc gttgctgcag ccgccgctgc cgccgcggcc ggaggaatcg    300

ggctgcgccg ggtgcctgga gccccccgga gaagcagcgg ccctgccgtg cggccactcg    360

ctttgccgag gctgcgccca acgcgccgcc gacgcggcgg gcccgggttg ccctcgctgc    420

cgcgcccgcg gcccaggctg ggcccgccgt cgggcccgcg acgacggcca ggccgactca    480

gaggtgctgg gcgagtgcgc ccgccgcagc caacccgagc gctgccgccc gcgccgggac    540

gggggcgcgg ctgccgcggg gcccaggcca gagcaggagc cgcgtgccgc gcctgcggag    600

ccagacttta tattcagagc accaatcaaa ttaagcaagc ctggggaact tcgtgaggaa    660

tatgaaagct tgagaaagct gagagaagaa aagttacaag aggaaaaacc ctctgaagat    720

caaatccaca agctgttacc agaggataca gaaacaggga aaaggaaaat ggatgaacag    780

aaaaaaagag atgaaccatt agtactgaaa acaaatctgg aacgttgtcc tgcacgtctc    840

tcagattcag agaatgaaga accttctcga ggccagatga cacagacaca tcgctcggca    900

tttgtttcca agaacaactc ctactcctta gctttcctgg cagggaagct aaactccaag    960

gtggaaagga gtcagagctg tagtgacaca gcccaggaaa gagcgaagag cagagtcaga   1020

gcagttccag gcaacaaagc caaggtcaca actatgactc cagcctccaa ccccatcatt   1080

ggtgtcctct tgtcaactca aaacaaccgc tgcgtctcgg cccctgactt aaccatcgaa   1140

aagcgtctac ccttcagctc cctttcatcc ttggcttccc tgcataagcc agagcgttct   1200

gtcagccctg agagcaatga cagcatctcc gaagaactaa accatttcaa gcccattgtc   1260

tgctcaccat gtactcctcc caagagactc cctgatggcc gtgtgctaag tcctctcatc   1320

atcaaatcaa ctccacgcaa cctaaacaga agcctgcaga agcagacttc ttatgaggcc   1380

agtccacgga tcctcaaaaa gtgggaacag atctttcagg agcggcagat caaaaagacc   1440

ctttcaaaag ccactcttac ctctctggct cctgaaatgg gggaagagtt actaggctct   1500

gaaggtatcc attctagcaa ggagaagcca cttgtggctg taaatacaag attatctggt   1560

gggcaggtcc tctctgagta tactggaccc acctctgctg atcttgatca tttcccctct   1620

gttagccaaa caaaagcaga acaggacagt gataataaaa gtagcactga gatcccactg   1680

gaaacctgct gttcctcaga actcaaaggg ggaggcagtg ggacttcttt ggagagggag   1740

cagtttgagg ggttagggtc aactccagat gccaagttag acaaaacctg tataagcaga   1800

gccatgaaaa tcaccacagt taattcagtg ctaccccaaa acagtgtttt gggtggagtc   1860

ctcaaaacaa agcaacaatt gaagacatta aatcattttg atctgactaa tggtgttcta   1920

gttgagagcc taagtgaaga gccacttcct tctttgcgtc gaggccggaa aagacactgc   1980

aagaccaagc acttagaaca aaatggctcc cttaaaaaac tgcgacaaac cagtggggag   2040

gtgggtctgg ccccaacaga cccagtcctg cgagagatgg agcagaagct tcagcaagag   2100

gaagaagacc gacagttggc tctgcagttg cagcgcatgt tcgacaatga gaggcggact   2160

gtgagccggc gaaaaggaag tgtggatcag tatctcctac ggtccagcaa catggccggg   2220

gccaagtagc acctaatgaa gtgttaccta tttttaaaag gattggagaa ggtacctgga   2280

tccttgtgga ctgccactgc tggctgcctc ctctccaact catcagaaga gcattttgac   2340

aaagacagag gacttggacc agggcatgcc ctgttgggga tgtttctgtc agcaaggaca   2400

tggcatggaa tcaagtgggc tgatgtgttg ttatttaaac agtaccaaag tgcattcttc   2460

aatgtatgtt tgcctgcttg aagcaaggcc caagttgaga atacagtaaa ggaaactcat   2520

gaaagtggat gttctgttta tagtcagagt cttgtctctg gtgaacaatc tcagacaaaa   2580

acatgggtta agcttaggct gtgtgtggat ttttggtgct gtatgtgctc tgggagatgc   2640

cccatgttgg atgtcttgct ttggcattca gaatggcagt agagattagg agcagggatg   2700

gggtttccat ggtgtacaac tacgtctttt ggcataagtt atgtccagtt tacagtttgc   2760

tccaatttac tgtcatgttc acattcaacc attcatgctc ctaatgaagg aaccaagaaa   2820

gagtctgagt aaagaacgaa tatacaggat gacactgtcc ctgcacatta gggctgtact   2880

cacaagatct ggtttttaaa aatacccttt tttggagcca ttgttcagga atttgttaag   2940

atccccttgg tgtcagtttc tcatacaaca gagaacaaat gtatccctgt tgcatctgaa   3000

ctggaaaacc atttttagag ggaagtgtga caatgctgct gtggcctggg ttccaagaaa   3060

gaatgcatgt ggcacccagt ctattgccct gtgcacccac tctttattgc cgctgggcca   3120

ggcaccaggt catgcctggg ccaaggaggg gagatcctga caaggggatg ccaccttgtg   3180

gccagcaagt ggggcccagc tgagctctga ggcctgtggc cggctggtca accttgaggt   3240

gcggtccagg gcacagagcc ctcggggaga gctggggcac aggccgggtg gtgcacacag   3300

cccccatgca cagctctagc cttgtgagtc actggctgtg ggctcctggc agaactcatc   3360

catgaactcg aggaagtggc cgaacttggg ctggctctca ctcagcgctg ggcaggccat   3420

ggggagcggg gtagtcccga acactgtgcg cagagagcca ctcaccagct gccggtaacg   3480

tgcctggaac tccttcaaca gcctcttggc ctccaggtac tgcttgtggt tcaccagccg   3540

ccgttctgtc cactg                                                    3555


<210>  2767
<211>  742
<212>  PRT
<213>  Homo sapiens

<400>  2767


Met Gly Arg Glu Asp Glu Glu Ile Ala Leu Pro Thr Ala Arg Thr Ala 
1               5                   10                  15      


Pro Pro Ser Thr Leu Leu Pro Arg Asn Arg Leu Ser Leu Gln Thr Gly 
            20                  25                  30          


Asn Lys Met Ala Ala Ala Gly Pro Ser Thr Arg Ala Ser Ser Ala Ala 
        35                  40                  45              


Ala Ala Ala Ala Leu Ser Arg Arg Gly Arg Arg Gly Arg Cys Asp Glu 
    50                  55                  60                  


Thr Ala Ala Ala Lys Thr Gly Ala Pro Gly Pro Ala Ser Gly Pro Ser 
65                  70                  75                  80  


Leu Leu Val Leu Ser Pro Pro Leu Leu Gln Pro Pro Leu Pro Pro Arg 
                85                  90                  95      


Pro Glu Glu Ser Gly Cys Ala Gly Cys Leu Glu Pro Pro Gly Glu Ala 
            100                 105                 110         


Ala Ala Leu Pro Cys Gly His Ser Leu Cys Arg Gly Cys Ala Gln Arg 
        115                 120                 125             


Ala Ala Asp Ala Ala Gly Pro Gly Cys Pro Arg Cys Arg Ala Arg Gly 
    130                 135                 140                 


Pro Gly Trp Ala Arg Arg Arg Ala Arg Asp Asp Gly Gln Ala Asp Ser 
145                 150                 155                 160 


Glu Val Leu Gly Glu Cys Ala Arg Arg Ser Gln Pro Glu Arg Cys Arg 
                165                 170                 175     


Pro Arg Arg Asp Gly Gly Ala Ala Ala Ala Gly Pro Arg Pro Glu Gln 
            180                 185                 190         


Glu Pro Arg Ala Ala Pro Ala Glu Pro Asp Phe Ile Phe Arg Ala Pro 
        195                 200                 205             


Ile Lys Leu Ser Lys Pro Gly Glu Leu Arg Glu Glu Tyr Glu Ser Leu 
    210                 215                 220                 


Arg Lys Leu Arg Glu Glu Lys Leu Gln Glu Glu Lys Pro Ser Glu Asp 
225                 230                 235                 240 


Gln Ile His Lys Leu Leu Pro Glu Asp Thr Glu Thr Gly Lys Arg Lys 
                245                 250                 255     


Met Asp Glu Gln Lys Lys Arg Asp Glu Pro Leu Val Leu Lys Thr Asn 
            260                 265                 270         


Leu Glu Arg Cys Pro Ala Arg Leu Ser Asp Ser Glu Asn Glu Glu Pro 
        275                 280                 285             


Ser Arg Gly Gln Met Thr Gln Thr His Arg Ser Ala Phe Val Ser Lys 
    290                 295                 300                 


Asn Asn Ser Tyr Ser Leu Ala Phe Leu Ala Gly Lys Leu Asn Ser Lys 
305                 310                 315                 320 


Val Glu Arg Ser Gln Ser Cys Ser Asp Thr Ala Gln Glu Arg Ala Lys 
                325                 330                 335     


Ser Arg Val Arg Ala Val Pro Gly Asn Lys Ala Lys Val Thr Thr Met 
            340                 345                 350         


Thr Pro Ala Ser Asn Pro Ile Ile Gly Val Leu Leu Ser Thr Gln Asn 
        355                 360                 365             


Asn Arg Cys Val Ser Ala Pro Asp Leu Thr Ile Glu Lys Arg Leu Pro 
    370                 375                 380                 


Phe Ser Ser Leu Ser Ser Leu Ala Ser Leu His Lys Pro Glu Arg Ser 
385                 390                 395                 400 


Val Ser Pro Glu Ser Asn Asp Ser Ile Ser Glu Glu Leu Asn His Phe 
                405                 410                 415     


Lys Pro Ile Val Cys Ser Pro Cys Thr Pro Pro Lys Arg Leu Pro Asp 
            420                 425                 430         


Gly Arg Val Leu Ser Pro Leu Ile Ile Lys Ser Thr Pro Arg Asn Leu 
        435                 440                 445             


Asn Arg Ser Leu Gln Lys Gln Thr Ser Tyr Glu Ala Ser Pro Arg Ile 
    450                 455                 460                 


Leu Lys Lys Trp Glu Gln Ile Phe Gln Glu Arg Gln Ile Lys Lys Thr 
465                 470                 475                 480 


Leu Ser Lys Ala Thr Leu Thr Ser Leu Ala Pro Glu Met Gly Glu Glu 
                485                 490                 495     


Leu Leu Gly Ser Glu Gly Ile His Ser Ser Lys Glu Lys Pro Leu Val 
            500                 505                 510         


Ala Val Asn Thr Arg Leu Ser Gly Gly Gln Val Leu Ser Glu Tyr Thr 
        515                 520                 525             


Gly Pro Thr Ser Ala Asp Leu Asp His Phe Pro Ser Val Ser Gln Thr 
    530                 535                 540                 


Lys Ala Glu Gln Asp Ser Asp Asn Lys Ser Ser Thr Glu Ile Pro Leu 
545                 550                 555                 560 


Glu Thr Cys Cys Ser Ser Glu Leu Lys Gly Gly Gly Ser Gly Thr Ser 
                565                 570                 575     


Leu Glu Arg Glu Gln Phe Glu Gly Leu Gly Ser Thr Pro Asp Ala Lys 
            580                 585                 590         


Leu Asp Lys Thr Cys Ile Ser Arg Ala Met Lys Ile Thr Thr Val Asn 
        595                 600                 605             


Ser Val Leu Pro Gln Asn Ser Val Leu Gly Gly Val Leu Lys Thr Lys 
    610                 615                 620                 


Gln Gln Leu Lys Thr Leu Asn His Phe Asp Leu Thr Asn Gly Val Leu 
625                 630                 635                 640 


Val Glu Ser Leu Ser Glu Glu Pro Leu Pro Ser Leu Arg Arg Gly Arg 
                645                 650                 655     


Lys Arg His Cys Lys Thr Lys His Leu Glu Gln Asn Gly Ser Leu Lys 
            660                 665                 670         


Lys Leu Arg Gln Thr Ser Gly Glu Val Gly Leu Ala Pro Thr Asp Pro 
        675                 680                 685             


Val Leu Arg Glu Met Glu Gln Lys Leu Gln Gln Glu Glu Glu Asp Arg 
    690                 695                 700                 


Gln Leu Ala Leu Gln Leu Gln Arg Met Phe Asp Asn Glu Arg Arg Thr 
705                 710                 715                 720 


Val Ser Arg Arg Lys Gly Ser Val Asp Gln Tyr Leu Leu Arg Ser Ser 
                725                 730                 735     


Asn Met Ala Gly Ala Lys 
            740         

<210>  2768
<211>  7822
<212>  DNA
<213>  Homo sapiens

<400>  2768
aacgggaaac aagatggcgg ctgcaggtcc gagtactcgg gcctcttccg cggcggcagc     60

agccgctctg agtcggcggg gccggcgggg ccgctgtgac gagacggcgg cagctaagac    120

tggggcccca ggcccggctt ctggaccttc gctgttggtg ttgtcgccgc cgttgctgca    180

gccgccgctg ccgccgcggc cggaggaatc gggctgcgcc gggtgcctgg agccccccgg    240

agaagcagcg gccctgccgt gcggccactc gctttgccga ggctgcgccc aacgcgccgc    300

cgacgcggcg ggcccgggtt gccctcgctg ccgcgcccgc ggcccaggct gggcccgccg    360

tcgggcccgc gacgacggcc aggccgactc agaggtgctg ggcgagtgcg cccgccgcag    420

ccaacccgag cgctgccgcc cgcgccggga cgggggcgcg gctgccgcgg ggcccaggcc    480

agagcaggag ccgcgtgccg cgcctgcgga gccagacttt atattcagag caccaatcaa    540

attaagcaag cctggggaac ttcgtgagga atatgaaagc ttgagaaagc tgagagaaga    600

aaagttacaa gaggaaaaac cctctgaaga tcaaatccac aagctgttac cagaggatac    660

agaaacaggg aaaaggaaaa tggatgaaca gaaaaaaaga gatgaaccat tagtactgaa    720

aacaaatctg gaacgttgtc ctgcacgtct ctcagattca gagaatgaag aaccttctcg    780

aggccagatg acacagacac atcgctcggc atttgtttcc aagaacaact cctactcctt    840

agctttcctg gcagggaagc taaactccaa ggtggaaagg agtcagagct gtagtgacac    900

agcccaggaa agagcgaaga gcagagtcag agcagttcca ggcaacaaag ccaaggtcac    960

aactatgact ccagcctcca accccatcat tggtgtcctc ttgtcaactc aaaacaaccg   1020

ctgcgtctcg gcccctgact taaccatcga aaagcgtcta cccttcagct ccctttcatc   1080

cttggcttcc ctgcataagc cagagcgttc tgtcagccct gagagcaatg acagcatctc   1140

cgaagaacta aaccatttca agcccattgt ctgctcacca tgtactcctc ccaagagact   1200

ccctgatggc cgtgtgctaa gtcctctcat catcaaatca actccacgca acctaaacag   1260

aagcctgcag aagcagactt cttatgaggc cagtccacgg atcctcaaaa agtgggaaca   1320

gatctttcag gagcggcaga tcaaaaagac cctttcaaaa gccactctta cctctctggc   1380

tcctgaaatg ggggaagagt tactaggctc tgaaggtatc cattctagca aggagaagcc   1440

acttgtggct gtaaatacaa gattatctgg tgggcaggtc ctctctgagt atactggacc   1500

cacctctgct gatcttgatc atttcccctc tgttagccaa acaaaagcag aacaggacag   1560

tgataataaa agtagcactg agatcccact ggaaacctgc tgttcctcag aactcaaagg   1620

gggaggcagt gggacttctt tggagaggga gcagtttgag gggttagggt caactccaga   1680

tgccaagtta gacaaaacct gtataagcag agccatgaaa atcaccacag ttaattcagt   1740

gctaccccaa aacagtgttt tgggtggagt cctcaaaaca aagcaacaat tgaagacatt   1800

aaatcatttt gatctgacta atggtgttct agttgagagc ctaagtgaag agccacttcc   1860

ttctttgcgt cgaggccgga aaagacactg caagaccaag cacttagaac aaaatggctc   1920

ccttaaaaaa ctgcgacaaa ccagtgggga ggtgggtctg gccccaacag acccagtcct   1980

gcgagagatg gagcagaagc ttcagcaaga ggaagaagac cgacagttgg ctctgcagtt   2040

gcagcgcatg ttcgacaatg agaggcggac tgtgagccgg cgaaaaggaa gtgtggatca   2100

gtatctccta cggtccagca acatggccgg ggccaagtag cacctaatga agtgttacct   2160

atttttaaaa ggtcttaggc cttgatcatt tatcctgaag agctgagtgt tctcactttg   2220

gttttatttt aatggcaaaa cactgtctaa tatggttctg agaggttcca gggcctttgt   2280

agtcaatatc caagggaaaa gcatctccgt ttctctgtga cccaggccag aagcctgagt   2340

gacccatccc taagggcttc tgggccaaac ctggcagcac ccactgggaa tgagatttgg   2400

aacggcctca ggagcataat ggccacagtt agtaatggta aagaggggat accttcttaa   2460

actgatagac ttcctgactt ctttcagcag ggtattgttt taaatcagcc ttgcagataa   2520

aaattaattc catctttttc agacaagtga acaatttagt tccttggcag atccaaaatg   2580

atagatggtt atgttacgct ttctgctgtc ccttgccaaa aataagtaaa tatatcagtt   2640

aagattatgc ctttacaaaa gttaatttac attctctgtt taaaaaataa tatttggtga   2700

atgctatata gttgacagag cacatttaca gaccttatta atttagtctt tccaagagac   2760

ctctcatgta actggcatta gccccatttt tagatgatga aactgcagtg cagatgttct   2820

ggttctctca actaccaagt ggcataaccc atggattttc taaaggtttc ccaaatagat   2880

cacaacctaa gggtgtgcca ggggagccta ggggaagcta ggctgggcat tgaacactga   2940

tagtgcagaa tccacatgca aacaagatcg acagggtgga taaacatata tgtgcattat   3000

ccccatcccc cacagtttag agccttctgc ttttctgggg gtttcagcct atgagacaaa   3060

ctataatcag gcttcattat tacttttcaa atggccaagg gttatctgca atgttgatct   3120

aaaatcctaa aaaatcaccc tgaagtcagg caaggaacaa tacttaaact ccatactatg   3180

gaaacaaggt atctagctgg atgcagctgg taaattcagt cccatggacc tttgggggtt   3240

tattttcctt agcagctgac accatgtgtc ttttgcatcc ctggtggtgc ttggtgcttc   3300

tgcccatctg ggctcattga gaatagggat gaagatatga ttttagggaa tttctgatgg   3360

gctggcatgc cccatgtagt atgagttact atataaagtc atgtgactgg cattttaaca   3420

gaccttccag agcttatata tcccaatata tgttgtttcc tttgagtagc cccagcagga   3480

tactgcttag tttttccagt gccattggtg aaagcatttc tggaactgtc ttcaaagact   3540

agaaacactg actcccaaaa tgctagaact ggaagggacc ttaatggtta tctattccag   3600

cctcctccta aggtcctcct cagcttctag acctagaagc caaagtccag aacagtgacc   3660

cattgatcaa ggcagatagt ataactcctt ttaagtgttc tcagatttgc cttttctcag   3720

ggcaaatctt cagtgttttg tggttatttg tggttgagag agagagagaa tgtaatgtct   3780

gagactagcc agcagctatt tgaagcctct gggaaagaag gtggcttatc aagtgggttt   3840

gtagtaatga gtgctgctgt aaagcagagc cattttcttg tgcagctcat agttcccaaa   3900

cagttcccaa acagaaattc cagagatgtc ttaaacattg tggtcatcat tgagataggt   3960

ggaatctctt tggtgactac gttggtgggg aacatcactc acctgaatgt atgcattctg   4020

tgttctctgt gtgtgtgcac atatgcagat gtatgtttta aaaacattta ccaaactcat   4080

gattttgtag tcacaccact tcagttctgg gccctaccaa caatttatgt cctccaagag   4140

ctgctggagg gcatgtttgt gcccaaaaca gaagagctgg ctctggttta cagaagacag   4200

ggagggtgac cttactataa atgcccttag aggaaactta tcagttactg ccatttcacg   4260

catttccttt ttgatcttag taaatattat tggaaggcta gtcttgttgg taggagcaaa   4320

gacacttatt tttccacttg ccatctttct ctatatctcc agtaatttga aaaacacttt   4380

tcagttggaa ttgatttttg tctttggtaa aaagaaatat ttttaataga taaaagatat   4440

atattttaaa tatttcccca aattaatact ttcattttaa gaattgcata gcagttgtaa   4500

caagtgcaga atgaagaaca aattcttgtt aagcaaatag tccaaactct aggtccagct   4560

tactgccttc cccccttgta cctacagtga tgcctaggat ggtattgaca gttgttttct   4620

aaacttcctg ctgagcaaca gtccttcaaa tataggtaga gtggtctagg ttaaggaggg   4680

aggagggttg atctttaatc aggttggctt tggaggaagg aaaaaccact aaggtattat   4740

ctgaatttta agatgcttcc catccttaat aactaaaacc tgaatgcttt tctttctgaa   4800

aaatctccct ctctccttcc atgattctga agttggttaa aagtcgatat gttgatgtgt   4860

attatttggg ggaacagaaa aggacaagga aggaaacaga acgatgggaa gggtttgtga   4920

gctagaataa gaggtgcagg atttcacaaa acaaattcct cacaaatcat tgaagcccag   4980

ttcaccatac aaattaccca tgtcttactc tgttccttgt atatatgcat tctgggtttt   5040

tttattatta aaggggaagt taggggggag ggtgaaggtc agtctgaggg gaaatccagg   5100

aaatgtggtg cccttagaag ggggctgtca gctcttttcc atagagaggg aaagaaactt   5160

tgagaaaatg ttcttgaccc attgattgta tctgctggaa gaagtcatct gggcctgttg   5220

ggttggtatc agatcagggg attatgcatc cagcccctgg cccctttaat ctatttgcct   5280

ctttttaaaa aaggttaagt cttcttgggt gaggcttgcc agggaaactc ctaagtggct   5340

tcacttattt tttaaatttt aatttaattt ttaaattttt gcttggaagc agcactggta   5400

ataaatgttt tattttttgt tcattttccc taaaggaaaa atgtccttaa gagattaaag   5460

ctcttaattg attactgtct ggttacaaac tggcaaactg actaaaatgg gaagctgcca   5520

ccgtgcctga ctcatgtagc tgatgaccga aggctcatcc tttcttttct atttgacaga   5580

catttactga gcttcagact tgagccaacc ctgagctgga ctgtggagat aaagcagttc   5640

ctgctcttga ggagctcaat gtctaatgga atgcatttga atgtatgtgt ggctggagag   5700

ttcatttatg gtcttaggaa agccatttct ggtcccattt agaaaactga ccagcaccca   5760

gcaagctgca ttctacattt tagagacccc attggtattt gtgaatttga ttgcaccacc   5820

gcttttcctt tactaagtaa tgttatggaa ggagaatgaa ttttctcctc tagtgattac   5880

aggacattaa catctcttca gaagctgctt ttagcttaag ccccaagaag tgaggtgggt   5940

tgtggatcac tgacatggtc aggggaggcc cacacctcaa ttcagtaacc acctaatctc   6000

tcccccaacc tgatctctca tcagagctgg cagcaacttg ggattccttt cctttttcct   6060

gcctaacttt tcattgaaat gtctagtagg agagtgagaa aagagaacaa aggctgggtc   6120

acagtcatag aatgttacag ctggaatggg catggaaatc atccaagtta aacttcttct   6180

ctgccccccg cccccacttt tttttttttt tttttttaac caaacgaact tgtgatccag   6240

tgccctattt tatagtgtgg ttttccaggg tctgaataaa taatcattaa agtttgacac   6300

acgcagacac acgcaccaat gatggggata cccccaaatg atttaggagg ttattttatt   6360

ttaatagttt tttcttcctg atttttttca gttagttaga gttaaatgta cctatagccc   6420

ctgaatacat gctcaggtag agaaagtctc catagtataa gtaagtaata tgaatgtgga   6480

atcttggaaa gtgatatatt ttgattggaa taattttaat taaatttaat gattttaatt   6540

aagaattaaa agccagctag ccaaattttc tttaaaaatt ggaaactcat tatggtctta   6600

aattgtcctc aggcagcctt ttcctcatca acccatagag tggtcttttg aactggtatc   6660

taaacatacc tggttatgaa ttctcaaaag agaaagcagg tctggggcgg ggtggtcagg   6720

agacagattc tagggaaagt gctgaagaga ttttcttctg aagatgatct aggaaatgca   6780

tctttataca tgattgttag ctgctgtagc tttctgaaga agattgtaga aaagagacta   6840

agatatatgc aagggtcacc agtttagaga tcagtcaaat tggaaaaagt gccaagactg   6900

gatgtgcaga ttgttctatg tattatcagt atttttttcc tcttaagaaa aaaatttact   6960

ctctctcctt tgtgagtaaa tgcctcctta atgcctttta agtaaggtgg caacttttaa   7020

ctgtcatctt gtgagaggca acctcaaact ctaagcagac tccctctctc cctttctggt   7080

gtcttaaatc aagaactagt ttgaagccaa ggcaaagcaa ggtttgttca tcttcctttc   7140

ctgtcattta aggtaaaaca ggcaatgaac tcgctcttca aataccatag ttcaagagta   7200

gctgttggcc ctggttccag attaatatag cagcaggcag attgcccctt cttggggcca   7260

ccaccctcca aagctgtgcc accaatgaga gcattgggtt caagtttgca tcaaacatgg   7320

tattaccaac gctgagcctc cagcagagca cttaaaagtc ctagtgagag aatagatact   7380

atgcaaggga aaaaaattta aatgccaacg aatagttttt ttttttttga acctgataca   7440

ctgtttgttt actctcaact ctttgtacaa atattattgt cctaagggcc ttttcccctc   7500

ctgcctagaa aataggttgt gtattggttt tattcaacct gctgtctgct ttaggattgg   7560

agaaggtacc tggatccttg tggactgcca ctgctggctg cctcctctcc aactcatcag   7620

aagagcattt tgacaaagac agaggacttg gaccagggca tgccctgttg gggatgtttc   7680

tgtcagcaag gacatggcat ggaatcaagt gggctgatgt gttgttattt aaacagtacc   7740

aaagtgcatt cttcaatgta tgtttgcctg cttgaagcaa ggcccaagtt gagaatacag   7800

taaaggaaac tcatgaaagt gg                                            7822


<210>  2769
<211>  708
<212>  PRT
<213>  Homo sapiens

<400>  2769


Met Ala Ala Ala Gly Pro Ser Thr Arg Ala Ser Ser Ala Ala Ala Ala 
1               5                   10                  15      


Ala Ala Leu Ser Arg Arg Gly Arg Arg Gly Arg Cys Asp Glu Thr Ala 
            20                  25                  30          


Ala Ala Lys Thr Gly Ala Pro Gly Pro Ala Ser Gly Pro Ser Leu Leu 
        35                  40                  45              


Val Leu Ser Pro Pro Leu Leu Gln Pro Pro Leu Pro Pro Arg Pro Glu 
    50                  55                  60                  


Glu Ser Gly Cys Ala Gly Cys Leu Glu Pro Pro Gly Glu Ala Ala Ala 
65                  70                  75                  80  


Leu Pro Cys Gly His Ser Leu Cys Arg Gly Cys Ala Gln Arg Ala Ala 
                85                  90                  95      


Asp Ala Ala Gly Pro Gly Cys Pro Arg Cys Arg Ala Arg Gly Pro Gly 
            100                 105                 110         


Trp Ala Arg Arg Arg Ala Arg Asp Asp Gly Gln Ala Asp Ser Glu Val 
        115                 120                 125             


Leu Gly Glu Cys Ala Arg Arg Ser Gln Pro Glu Arg Cys Arg Pro Arg 
    130                 135                 140                 


Arg Asp Gly Gly Ala Ala Ala Ala Gly Pro Arg Pro Glu Gln Glu Pro 
145                 150                 155                 160 


Arg Ala Ala Pro Ala Glu Pro Asp Phe Ile Phe Arg Ala Pro Ile Lys 
                165                 170                 175     


Leu Ser Lys Pro Gly Glu Leu Arg Glu Glu Tyr Glu Ser Leu Arg Lys 
            180                 185                 190         


Leu Arg Glu Glu Lys Leu Gln Glu Glu Lys Pro Ser Glu Asp Gln Ile 
        195                 200                 205             


His Lys Leu Leu Pro Glu Asp Thr Glu Thr Gly Lys Arg Lys Met Asp 
    210                 215                 220                 


Glu Gln Lys Lys Arg Asp Glu Pro Leu Val Leu Lys Thr Asn Leu Glu 
225                 230                 235                 240 


Arg Cys Pro Ala Arg Leu Ser Asp Ser Glu Asn Glu Glu Pro Ser Arg 
                245                 250                 255     


Gly Gln Met Thr Gln Thr His Arg Ser Ala Phe Val Ser Lys Asn Asn 
            260                 265                 270         


Ser Tyr Ser Leu Ala Phe Leu Ala Gly Lys Leu Asn Ser Lys Val Glu 
        275                 280                 285             


Arg Ser Gln Ser Cys Ser Asp Thr Ala Gln Glu Arg Ala Lys Ser Arg 
    290                 295                 300                 


Val Arg Ala Val Pro Gly Asn Lys Ala Lys Val Thr Thr Met Thr Pro 
305                 310                 315                 320 


Ala Ser Asn Pro Ile Ile Gly Val Leu Leu Ser Thr Gln Asn Asn Arg 
                325                 330                 335     


Cys Val Ser Ala Pro Asp Leu Thr Ile Glu Lys Arg Leu Pro Phe Ser 
            340                 345                 350         


Ser Leu Ser Ser Leu Ala Ser Leu His Lys Pro Glu Arg Ser Val Ser 
        355                 360                 365             


Pro Glu Ser Asn Asp Ser Ile Ser Glu Glu Leu Asn His Phe Lys Pro 
    370                 375                 380                 


Ile Val Cys Ser Pro Cys Thr Pro Pro Lys Arg Leu Pro Asp Gly Arg 
385                 390                 395                 400 


Val Leu Ser Pro Leu Ile Ile Lys Ser Thr Pro Arg Asn Leu Asn Arg 
                405                 410                 415     


Ser Leu Gln Lys Gln Thr Ser Tyr Glu Ala Ser Pro Arg Ile Leu Lys 
            420                 425                 430         


Lys Trp Glu Gln Ile Phe Gln Glu Arg Gln Ile Lys Lys Thr Leu Ser 
        435                 440                 445             


Lys Ala Thr Leu Thr Ser Leu Ala Pro Glu Met Gly Glu Glu Leu Leu 
    450                 455                 460                 


Gly Ser Glu Gly Ile His Ser Ser Lys Glu Lys Pro Leu Val Ala Val 
465                 470                 475                 480 


Asn Thr Arg Leu Ser Gly Gly Gln Val Leu Ser Glu Tyr Thr Gly Pro 
                485                 490                 495     


Thr Ser Ala Asp Leu Asp His Phe Pro Ser Val Ser Gln Thr Lys Ala 
            500                 505                 510         


Glu Gln Asp Ser Asp Asn Lys Ser Ser Thr Glu Ile Pro Leu Glu Thr 
        515                 520                 525             


Cys Cys Ser Ser Glu Leu Lys Gly Gly Gly Ser Gly Thr Ser Leu Glu 
    530                 535                 540                 


Arg Glu Gln Phe Glu Gly Leu Gly Ser Thr Pro Asp Ala Lys Leu Asp 
545                 550                 555                 560 


Lys Thr Cys Ile Ser Arg Ala Met Lys Ile Thr Thr Val Asn Ser Val 
                565                 570                 575     


Leu Pro Gln Asn Ser Val Leu Gly Gly Val Leu Lys Thr Lys Gln Gln 
            580                 585                 590         


Leu Lys Thr Leu Asn His Phe Asp Leu Thr Asn Gly Val Leu Val Glu 
        595                 600                 605             


Ser Leu Ser Glu Glu Pro Leu Pro Ser Leu Arg Arg Gly Arg Lys Arg 
    610                 615                 620                 


His Cys Lys Thr Lys His Leu Glu Gln Asn Gly Ser Leu Lys Lys Leu 
625                 630                 635                 640 


Arg Gln Thr Ser Gly Glu Val Gly Leu Ala Pro Thr Asp Pro Val Leu 
                645                 650                 655     


Arg Glu Met Glu Gln Lys Leu Gln Gln Glu Glu Glu Asp Arg Gln Leu 
            660                 665                 670         


Ala Leu Gln Leu Gln Arg Met Phe Asp Asn Glu Arg Arg Thr Val Ser 
        675                 680                 685             


Arg Arg Lys Gly Ser Val Asp Gln Tyr Leu Leu Arg Ser Ser Asn Met 
    690                 695                 700                 


Ala Gly Ala Lys 
705             

<210>  2770
<211>  8418
<212>  DNA
<213>  Homo sapiens

<400>  2770
aacgggaaac aagatggcgg ctgcaggtcc gagtactcgg gcctcttccg cggcggcagc     60

agccgctctg agtcggcggg gccggcgggg ccgctgtgac gagacggcgg cagctaagac    120

tggggcccca ggcccggctt ctggaccttc gctgttggtg ttgtcgccgc cgttgctgca    180

gccgccgctg ccgccgcggc cggaggaatc gggctgcgcc gggtgcctgg agccccccgg    240

agaagcagcg gccctgccgt gcggccactc gctttgccga ggctgcgccc aacgcgccgc    300

cgacgcggcg ggcccgggtt gccctcgctg ccgcgcccgc ggcccaggct gggcccgccg    360

tcgggcccgc gacgacggcc aggccgactc agaggtgctg ggcgagtgcg cccgccgcag    420

ccaacccgag cgctgccgcc cgcgccggga cgggggcgcg gctgccgcgg ggcccaggcc    480

agagcaggag ccgcgtgccg cgcctgcgga gccagacttt atattcagag caccaatcaa    540

attaagcaag cctggggaac ttcgtgagga atatgaaagc ttgagaaagc tgagagaaga    600

aaagttacaa gaggaaaaac cctctgaaga tcaaatccac aagctgttac cagaggatac    660

agaaacaggg aaaaggaaaa tggatgaaca gaaaaaaaga gatgaaccat tagtactgaa    720

aacaaatctg gaacgttgtc ctgcacgtct ctcagattca gagaatgaag aaccttctcg    780

aggccagatg acacagacac atcgctcggc atttgtttcc aagaacaact cctactcctt    840

agctttcctg gcagggaagc taaactccaa ggtggaaagg agtcagagct gtagtgacac    900

agcccaggaa agagcgaaga gcagagtcag agcagttcca ggcaacaaag ccaaggtcac    960

aactatgact ccagcctcca accccatcat tggtgtcctc ttgtcaactc aaaacaaccg   1020

ctgcgtctcg gcccctgact taaccatcga aaagcgtcta cccttcagct ccctttcatc   1080

cttggcttcc ctgcataagc cagagcgttc tgtcagccct gagagcaatg acagcatctc   1140

cgaagaacta aaccatttca agcccattgt ctgctcacca tgtactcctc ccaagagact   1200

ccctgatggc cgtgtgctaa gtcctctcat catcaaatca actccacgca acctaaacag   1260

aagcctgcag aagcagactt cttatgaggc cagtccacgg atcctcaaaa agtgggaaca   1320

gatctttcag gagcggcaga tcaaaaagac cctttcaaaa gccactctta cctctctggc   1380

tcctgaaatg ggggaagagt tactaggctc tgaaggtatc cattctagca aggagaagcc   1440

acttgtggct gtaaatacaa gattatctgg tgggcaggtc ctctctgagt atactggacc   1500

cacctctgct gatcttgatc atttcccctc tgttagccaa acaaaagcag aacaggacag   1560

tgataataaa agtagcactg agatcccact ggaaacctgc tgttcctcag aactcaaagg   1620

gggaggcagt gggacttctt tggagaggga gcagtttgag gggttagggt caactccaga   1680

tgccaagtta gacaaaacct gtataagcag agccatgaaa atcaccacag ttaattcagt   1740

gctaccccaa aacagtgttt tgggtggagt cctcaaaaca aagcaacaat tgaagacatt   1800

aaatcatttt gatctgacta atggtgttct agttgagagc ctaagtgaag agccacttcc   1860

ttctttgcgt cgaggccgga aaagacactg caagaccaag cacttagaac aaaatggctc   1920

ccttaaaaaa ctgcgacaaa ccagtgggga ggtgggtctg gccccaacag acccagtcct   1980

gcgagagatg gagcagaagc ttcagcaaga ggaagaagac cgacagttgg ctctgcagtt   2040

gcagcgcatg ttcgacaatg agaggcggac tgtgagccgg cgaaaaggaa gtgtggatca   2100

gtatctccta cggtccagca acatggccgg ggccaagtag cacctaatga agtgttacct   2160

atttttaaaa ggtcttaggc cttgatcatt tatcctgaag agctgagtgt tctcactttg   2220

gttttatttt aatggcaaaa cactgtctaa tatggttctg agaggttcca gggcctttgt   2280

agtcaatatc caagggaaaa gcatctccgt ttctctgtga cccaggccag aagcctgagt   2340

gacccatccc taagggcttc tgggccaaac ctggcagcac ccactgggaa tgagatttgg   2400

aacggcctca ggagcataat ggccacagtt agtaatggta aagaggggat accttcttaa   2460

actgatagac ttcctgactt ctttcagcag ggtattgttt taaatcagcc ttgcagataa   2520

aaattaattc catctttttc agacaagtga acaatttagt tccttggcag atccaaaatg   2580

atagatggtt atgttacgct ttctgctgtc ccttgccaaa aataagtaaa tatatcagtt   2640

aagattatgc ctttacaaaa gttaatttac attctctgtt taaaaaataa tatttggtga   2700

atgctatata gttgacagag cacatttaca gaccttatta atttagtctt tccaagagac   2760

ctctcatgta actggcatta gccccatttt tagatgatga aactgcagtg cagatgttct   2820

ggttctctca actaccaagt ggcataaccc atggattttc taaaggtttc ccaaatagat   2880

cacaacctaa gggtgtgcca ggggagccta ggggaagcta ggctgggcat tgaacactga   2940

tagtgcagaa tccacatgca aacaagatcg acagggtgga taaacatata tgtgcattat   3000

ccccatcccc cacagtttag agccttctgc ttttctgggg gtttcagcct atgagacaaa   3060

ctataatcag gcttcattat tacttttcaa atggccaagg gttatctgca atgttgatct   3120

aaaatcctaa aaaatcaccc tgaagtcagg caaggaacaa tacttaaact ccatactatg   3180

gaaacaaggt atctagctgg atgcagctgg taaattcagt cccatggacc tttgggggtt   3240

tattttcctt agcagctgac accatgtgtc ttttgcatcc ctggtggtgc ttggtgcttc   3300

tgcccatctg ggctcattga gaatagggat gaagatatga ttttagggaa tttctgatgg   3360

gctggcatgc cccatgtagt atgagttact atataaagtc atgtgactgg cattttaaca   3420

gaccttccag agcttatata tcccaatata tgttgtttcc tttgagtagc cccagcagga   3480

tactgcttag tttttccagt gccattggtg aaagcatttc tggaactgtc ttcaaagact   3540

agaaacactg actcccaaaa tgctagaact ggaagggacc ttaatggtta tctattccag   3600

cctcctccta aggtcctcct cagcttctag acctagaagc caaagtccag aacagtgacc   3660

cattgatcaa ggcagatagt ataactcctt ttaagtgttc tcagatttgc cttttctcag   3720

ggcaaatctt cagtgttttg tggttatttg tggttgagag agagagagaa tgtaatgtct   3780

gagactagcc agcagctatt tgaagcctct gggaaagaag gtggcttatc aagtgggttt   3840

gtagtaatga gtgctgctgt aaagcagagc cattttcttg tgcagctcat agttcccaaa   3900

cagttcccaa acagaaattc cagagatgtc ttaaacattg tggtcatcat tgagataggt   3960

ggaatctctt tggtgactac gttggtgggg aacatcactc acctgaatgt atgcattctg   4020

tgttctctgt gtgtgtgcac atatgcagat gtatgtttta aaaacattta ccaaactcat   4080

gattttgtag tcacaccact tcagttctgg gccctaccaa caatttatgt cctccaagag   4140

ctgctggagg gcatgtttgt gcccaaaaca gaagagctgg ctctggttta cagaagacag   4200

ggagggtgac cttactataa atgcccttag aggaaactta tcagttactg ccatttcacg   4260

catttccttt ttgatcttag taaatattat tggaaggcta gtcttgttgg taggagcaaa   4320

gacacttatt tttccacttg ccatctttct ctatatctcc agtaatttga aaaacacttt   4380

tcagttggaa ttgatttttg tctttggtaa aaagaaatat ttttaataga taaaagatat   4440

atattttaaa tatttcccca aattaatact ttcattttaa gaattgcata gcagttgtaa   4500

caagtgcaga atgaagaaca aattcttgtt aagcaaatag tccaaactct aggtccagct   4560

tactgccttc cccccttgta cctacagtga tgcctaggat ggtattgaca gttgttttct   4620

aaacttcctg ctgagcaaca gtccttcaaa tataggtaga gtggtctagg ttaaggaggg   4680

aggagggttg atctttaatc aggttggctt tggaggaagg aaaaaccact aaggtattat   4740

ctgaatttta agatgcttcc catccttaat aactaaaacc tgaatgcttt tctttctgaa   4800

aaatctccct ctctccttcc atgattctga agttggttaa aagtcgatat gttgatgtgt   4860

attatttggg ggaacagaaa aggacaagga aggaaacaga acgatgggaa gggtttgtga   4920

gctagaataa gaggtgcagg atttcacaaa acaaattcct cacaaatcat tgaagcccag   4980

ttcaccatac aaattaccca tgtcttactc tgttccttgt atatatgcat tctgggtttt   5040

tttattatta aaggggaagt taggggggag ggtgaaggtc agtctgaggg gaaatccagg   5100

aaatgtggtg cccttagaag ggggctgtca gctcttttcc atagagaggg aaagaaactt   5160

tgagaaaatg ttcttgaccc attgattgta tctgctggaa gaagtcatct gggcctgttg   5220

ggttggtatc agatcagggg attatgcatc cagcccctgg cccctttaat ctatttgcct   5280

ctttttaaaa aaggttaagt cttcttgggt gaggcttgcc agggaaactc ctaagtggct   5340

tcacttattt tttaaatttt aatttaattt ttaaattttt gcttggaagc agcactggta   5400

ataaatgttt tattttttgt tcattttccc taaaggaaaa atgtccttaa gagattaaag   5460

ctcttaattg attactgtct ggttacaaac tggcaaactg actaaaatgg gaagctgcca   5520

ccgtgcctga ctcatgtagc tgatgaccga aggctcatcc tttcttttct atttgacaga   5580

catttactga gcttcagact tgagccaacc ctgagctgga ctgtggagat aaagcagttc   5640

ctgctcttga ggagctcaat gtctaatgga atgcatttga atgtatgtgt ggctggagag   5700

ttcatttatg gtcttaggaa agccatttct ggtcccattt agaaaactga ccagcaccca   5760

gcaagctgca ttctacattt tagagacccc attggtattt gtgaatttga ttgcaccacc   5820

gcttttcctt tactaagtaa tgttatggaa ggagaatgaa ttttctcctc tagtgattac   5880

aggacattaa catctcttca gaagctgctt ttagcttaag ccccaagaag tgaggtgggt   5940

tgtggatcac tgacatggtc aggggaggcc cacacctcaa ttcagtaacc acctaatctc   6000

tcccccaacc tgatctctca tcagagctgg cagcaacttg ggattccttt cctttttcct   6060

gcctaacttt tcattgaaat gtctagtagg agagtgagaa aagagaacaa aggctgggtc   6120

acagtcatag aatgttacag ctggaatggg catggaaatc atccaagtta aacttcttct   6180

ctgccccccg cccccacttt tttttttttt tttttttaac caaacgaact tgtgatccag   6240

tgccctattt tatagtgtgg ttttccaggg tctgaataaa taatcattaa agtttgacac   6300

acgcagacac acgcaccaat gatggggata cccccaaatg atttaggagg ttattttatt   6360

ttaatagttt tttcttcctg atttttttca gttagttaga gttaaatgta cctatagccc   6420

ctgaatacat gctcaggtag agaaagtctc catagtataa gtaagtaata tgaatgtgga   6480

atcttggaaa gtgatatatt ttgattggaa taattttaat taaatttaat gattttaatt   6540

aagaattaaa agccagctag ccaaattttc tttaaaaatt ggaaactcat tatggtctta   6600

aattgtcctc aggcagcctt ttcctcatca acccatagag tggtcttttg aactggtatc   6660

taaacatacc tggttatgaa ttctcaaaag agaaagcagg tctggggcgg ggtggtcagg   6720

agacagattc tagggaaagt gctgaagaga ttttcttctg aagatgatct aggaaatgca   6780

tctttataca tgattgttag ctgctgtagc tttctgaaga agattgtaga aaagagacta   6840

agatatatgc aagggtcacc agtttagaga tcagtcaaat tggaaaaagt gccaagactg   6900

gatgtgcaga ttgttctatg tattatcagt atttttttcc tcttaagaaa aaaatttact   6960

ctctctcctt tgtgagtaaa tgcctcctta atgcctttta agtaaggtgg caacttttaa   7020

ctgtcatctt gtgagaggca acctcaaact ctaagcagac tccctctctc cctttctggt   7080

gtcttaaatc aagaactagt ttgaagccaa ggcaaagcaa ggtttgttca tcttcctttc   7140

ctgtcattta aggtaaaaca ggcaatgaac tcgctcttca aataccatag ttcaagagta   7200

gctgttggcc ctggttccag attaatatag cagcaggcag attgcccctt cttggggcca   7260

ccaccctcca aagctgtgcc accaatgaga gcattgggtt caagtttgca tcaaacatgg   7320

tattaccaac gctgagcctc cagcagagca cttaaaagtc ctagtgagag aatagatact   7380

atgcaaggga aaaaaattta aatgccaacg aatagttttt ttttttttga acctgataca   7440

ctgtttgttt actctcaact ctttgtacaa atattattgt cctaagggcc ttttcccctc   7500

ctgcctagaa aataggttgt gtattggttt tattcaacct gctgtctgct ttaggattgg   7560

agaaggtacc tggatccttg tggactgcca ctgctggctg cctcctctcc aactcatcag   7620

aagagcattt tgacaaagac agaggacttg gaccagggca tgccctgttg gggatgtttc   7680

tgtcagcaag gacatggcat ggaatcaagt gggctgatgt gttgttattt aaacagtacc   7740

aaagtgcatt cttcaatgta tgtttgcctg cttgaagcaa ggcccaagtt gagaatacag   7800

taaaggaaac tcatgaaagt ggatgttctg tttatagtca gagtcttgtc tctggtgaac   7860

aatctcagac aaaaacatgg gttaagctta ggctgtgtgt ggatttttgg tgctgtatgt   7920

gctctgggag atgccccatg ttggatgtct tgctttggca ttcagaatgg cagtagagat   7980

taggagcagg gatggggttt ccatggtgta caactacgtc ttttggcata agttatgtcc   8040

agtttacagt ttgctccaat ttactgtcat gttcacattc aaccattcat gctcctaatg   8100

aaggaaccaa gaaagagtct gagtaaagaa cgaatataca ggatgacact gtccctgcac   8160

attagggctg tactcacaag atctggtttt taaaaatacc cttttttgga gccattgttc   8220

aggaatttgt taagatcccc ttggtgtcag tttctcatac aacagagaac aaatgtatcc   8280

ctgttgcatc tgaactggaa aaccattttt agagggaagt gtgacaatgc tgctgtggcc   8340

tgggttccaa gaaagaatgc atgtggcacc cagtctattg ccctgtgcac ccactcttta   8400

ttgccgctgg gccaggca                                                 8418


<210>  2771
<211>  708
<212>  PRT
<213>  Homo sapiens

<400>  2771


Met Ala Ala Ala Gly Pro Ser Thr Arg Ala Ser Ser Ala Ala Ala Ala 
1               5                   10                  15      


Ala Ala Leu Ser Arg Arg Gly Arg Arg Gly Arg Cys Asp Glu Thr Ala 
            20                  25                  30          


Ala Ala Lys Thr Gly Ala Pro Gly Pro Ala Ser Gly Pro Ser Leu Leu 
        35                  40                  45              


Val Leu Ser Pro Pro Leu Leu Gln Pro Pro Leu Pro Pro Arg Pro Glu 
    50                  55                  60                  


Glu Ser Gly Cys Ala Gly Cys Leu Glu Pro Pro Gly Glu Ala Ala Ala 
65                  70                  75                  80  


Leu Pro Cys Gly His Ser Leu Cys Arg Gly Cys Ala Gln Arg Ala Ala 
                85                  90                  95      


Asp Ala Ala Gly Pro Gly Cys Pro Arg Cys Arg Ala Arg Gly Pro Gly 
            100                 105                 110         


Trp Ala Arg Arg Arg Ala Arg Asp Asp Gly Gln Ala Asp Ser Glu Val 
        115                 120                 125             


Leu Gly Glu Cys Ala Arg Arg Ser Gln Pro Glu Arg Cys Arg Pro Arg 
    130                 135                 140                 


Arg Asp Gly Gly Ala Ala Ala Ala Gly Pro Arg Pro Glu Gln Glu Pro 
145                 150                 155                 160 


Arg Ala Ala Pro Ala Glu Pro Asp Phe Ile Phe Arg Ala Pro Ile Lys 
                165                 170                 175     


Leu Ser Lys Pro Gly Glu Leu Arg Glu Glu Tyr Glu Ser Leu Arg Lys 
            180                 185                 190         


Leu Arg Glu Glu Lys Leu Gln Glu Glu Lys Pro Ser Glu Asp Gln Ile 
        195                 200                 205             


His Lys Leu Leu Pro Glu Asp Thr Glu Thr Gly Lys Arg Lys Met Asp 
    210                 215                 220                 


Glu Gln Lys Lys Arg Asp Glu Pro Leu Val Leu Lys Thr Asn Leu Glu 
225                 230                 235                 240 


Arg Cys Pro Ala Arg Leu Ser Asp Ser Glu Asn Glu Glu Pro Ser Arg 
                245                 250                 255     


Gly Gln Met Thr Gln Thr His Arg Ser Ala Phe Val Ser Lys Asn Asn 
            260                 265                 270         


Ser Tyr Ser Leu Ala Phe Leu Ala Gly Lys Leu Asn Ser Lys Val Glu 
        275                 280                 285             


Arg Ser Gln Ser Cys Ser Asp Thr Ala Gln Glu Arg Ala Lys Ser Arg 
    290                 295                 300                 


Val Arg Ala Val Pro Gly Asn Lys Ala Lys Val Thr Thr Met Thr Pro 
305                 310                 315                 320 


Ala Ser Asn Pro Ile Ile Gly Val Leu Leu Ser Thr Gln Asn Asn Arg 
                325                 330                 335     


Cys Val Ser Ala Pro Asp Leu Thr Ile Glu Lys Arg Leu Pro Phe Ser 
            340                 345                 350         


Ser Leu Ser Ser Leu Ala Ser Leu His Lys Pro Glu Arg Ser Val Ser 
        355                 360                 365             


Pro Glu Ser Asn Asp Ser Ile Ser Glu Glu Leu Asn His Phe Lys Pro 
    370                 375                 380                 


Ile Val Cys Ser Pro Cys Thr Pro Pro Lys Arg Leu Pro Asp Gly Arg 
385                 390                 395                 400 


Val Leu Ser Pro Leu Ile Ile Lys Ser Thr Pro Arg Asn Leu Asn Arg 
                405                 410                 415     


Ser Leu Gln Lys Gln Thr Ser Tyr Glu Ala Ser Pro Arg Ile Leu Lys 
            420                 425                 430         


Lys Trp Glu Gln Ile Phe Gln Glu Arg Gln Ile Lys Lys Thr Leu Ser 
        435                 440                 445             


Lys Ala Thr Leu Thr Ser Leu Ala Pro Glu Met Gly Glu Glu Leu Leu 
    450                 455                 460                 


Gly Ser Glu Gly Ile His Ser Ser Lys Glu Lys Pro Leu Val Ala Val 
465                 470                 475                 480 


Asn Thr Arg Leu Ser Gly Gly Gln Val Leu Ser Glu Tyr Thr Gly Pro 
                485                 490                 495     


Thr Ser Ala Asp Leu Asp His Phe Pro Ser Val Ser Gln Thr Lys Ala 
            500                 505                 510         


Glu Gln Asp Ser Asp Asn Lys Ser Ser Thr Glu Ile Pro Leu Glu Thr 
        515                 520                 525             


Cys Cys Ser Ser Glu Leu Lys Gly Gly Gly Ser Gly Thr Ser Leu Glu 
    530                 535                 540                 


Arg Glu Gln Phe Glu Gly Leu Gly Ser Thr Pro Asp Ala Lys Leu Asp 
545                 550                 555                 560 


Lys Thr Cys Ile Ser Arg Ala Met Lys Ile Thr Thr Val Asn Ser Val 
                565                 570                 575     


Leu Pro Gln Asn Ser Val Leu Gly Gly Val Leu Lys Thr Lys Gln Gln 
            580                 585                 590         


Leu Lys Thr Leu Asn His Phe Asp Leu Thr Asn Gly Val Leu Val Glu 
        595                 600                 605             


Ser Leu Ser Glu Glu Pro Leu Pro Ser Leu Arg Arg Gly Arg Lys Arg 
    610                 615                 620                 


His Cys Lys Thr Lys His Leu Glu Gln Asn Gly Ser Leu Lys Lys Leu 
625                 630                 635                 640 


Arg Gln Thr Ser Gly Glu Val Gly Leu Ala Pro Thr Asp Pro Val Leu 
                645                 650                 655     


Arg Glu Met Glu Gln Lys Leu Gln Gln Glu Glu Glu Asp Arg Gln Leu 
            660                 665                 670         


Ala Leu Gln Leu Gln Arg Met Phe Asp Asn Glu Arg Arg Thr Val Ser 
        675                 680                 685             


Arg Arg Lys Gly Ser Val Asp Gln Tyr Leu Leu Arg Ser Ser Asn Met 
    690                 695                 700                 


Ala Gly Ala Lys 
705             

<210>  2772
<211>  2339
<212>  DNA
<213>  Homo sapiens

<400>  2772
gtcttgctgg cgcgaggtag tcagaggacg tggccgcggg gcttgctggg acttgaggtt     60

agacgtcccg gccgtcggtt gccgcctaca ctgtctgccg tcgcgtcgca gttactaagg    120

cgtggggaag atagcggcag gcaccgcagt ggagcggctc cgagatcccc ggggggctcg    180

caggcgcgca tccctcctga ctgggacgtc gcctccgcag acccctcgga ggctgaagcg    240

acgccggagg caggcaaaga aacaagtgaa gaaacaaaaa aaaaaggaag ttaaggggcc    300

attcccaaag tcaaagatca agccaaggac actggttagt ggttcagaaa ggtaacctca    360

agaagaagcc caagggtttg gttggagcac aagctgaacg tcgggaaagc ctgaaggcga    420

cttcttttga gttcaagggg aagaaagagt ctcggcggga aaatcaggtg gaccttcctg    480

gacatatcct ggaccaggct tttctgctga agcaccactg tgtgaggaag ccatcagatc    540

tgtgcaccat taatgtgagt ggcctgaagt tctccaaggc caaggaaaat gacttcaagc    600

attttcattc tgtgatttat atcaatgcct cagaaaacct gctgcctcta gttcttggac    660

ctttccttca acagcctgac tgtggaggcc atctgtgatt tggggattct gccacacctc    720

cgtgtcctgc tcctcacagg caatggcctt acctccctgc cgcccaattt ggccgtcgca    780

gaacaggagg catctgtaac atcgctgaca agcaagaggt acatcctgag gttcccagcg    840

ctggagacac tgatgctgga tgacaacaga ctctccaacc ccagttgctt tgccagcctg    900

gctgggctca ggagatcgca aaagaggatg ctgtcctacc agtagctctc ttcccatctc    960

tctgcgagtt cgtctttcat aacaaccctc tggtggccca tacacgaggg gtccctccac   1020

tgctgaagag cttcctccag gagcgactgg gaatccactt aattcgaagg aagatagtaa   1080

agcctaagca tcatgttttg atgtctcgga aggaatcatg gaaggtgaaa agcgaaatcc   1140

caaaggtgcc gaagcagcct ctggtgctcc atcacccgcg catgacgaca accaagtctc   1200

cctcaaagga tatgctagag ccagaggcag agctggctga agatctgccc actaccaaaa   1260

gcacttctgt ggagtcagag atgcccactg agaacctgga aggccattcc ccgtcttgcc   1320

ggaccttcgt gccactgcct cccatctgct ccaactccac tgtgcatagt gaagagaccc   1380

tgtcccacct gagtgacaca actgtccgcc tcagcccaga gcgcccatca gatgaggact   1440

ccaagagcac agagtccatc ttcctgaccc aggtgagtga actgccttcc tccgtcatcc   1500

ataaggatga tttagagtta aaggagaaag accaaaagaa accaccaacg gcacccagag   1560

aggtgaaagg gactcggagg aaactcccaa ctgccttcct tcccagcaag taccacggct   1620

atgaagaact gctgacagcc aagcctgatc cagccttcat tgagccaaag ggaatccaga   1680

agaatgcaca agccctgcaa caaatgctga agcacccact cctgtgccac tcctccaagc   1740

ccaagctgga cactcttcag aaaccctatg ttcacaaaga gaaacgggtg ctgtcctgca   1800

ccagtggaca gaacggcggc tggtgaacca caagcagtac ctggaggcca agaggctgtt   1860

gaaggagttc caggcacgtt accggcagct gagtctcaat atgttgccca ggctggtctc   1920

aaactcctga gctcaaatga tcctcctgcc tcccaaagtg ctgttatcac aggagtcaac   1980

cactatgccc ggcttcctaa taatttttac tgctgctctc aaagtttttg acaacgcact   2040

tgtgttgctg gcaaacaaca ttttcaccgc aatgctgagc cactgctaac agaccattag   2100

ctaaaaattt acaaaagtga aaaaaatcat gtatccattt aaatattcaa atgaatcatg   2160

ttggtgtttt ctcaatatgg agttctgtac aagtttttgt ttctttgttt tcattgcttt   2220

tggttgttat ttataaggat ttgagaactt ggtctctaga agagagtttt tatactgaaa   2280

aagactaagg gagggtgaga aagtagcatt ttaaatgtga ataaaaaata tcaattgct    2339


<210>  2773
<211>  241
<212>  PRT
<213>  Homo sapiens

<400>  2773


Met Ser Arg Lys Glu Ser Trp Lys Val Lys Ser Glu Ile Pro Lys Val 
1               5                   10                  15      


Pro Lys Gln Pro Leu Val Leu His His Pro Arg Met Thr Thr Thr Lys 
            20                  25                  30          


Ser Pro Ser Lys Asp Met Leu Glu Pro Glu Ala Glu Leu Ala Glu Asp 
        35                  40                  45              


Leu Pro Thr Thr Lys Ser Thr Ser Val Glu Ser Glu Met Pro Thr Glu 
    50                  55                  60                  


Asn Leu Glu Gly His Ser Pro Ser Cys Arg Thr Phe Val Pro Leu Pro 
65                  70                  75                  80  


Pro Ile Cys Ser Asn Ser Thr Val His Ser Glu Glu Thr Leu Ser His 
                85                  90                  95      


Leu Ser Asp Thr Thr Val Arg Leu Ser Pro Glu Arg Pro Ser Asp Glu 
            100                 105                 110         


Asp Ser Lys Ser Thr Glu Ser Ile Phe Leu Thr Gln Val Ser Glu Leu 
        115                 120                 125             


Pro Ser Ser Val Ile His Lys Asp Asp Leu Glu Leu Lys Glu Lys Asp 
    130                 135                 140                 


Gln Lys Lys Pro Pro Thr Ala Pro Arg Glu Val Lys Gly Thr Arg Arg 
145                 150                 155                 160 


Lys Leu Pro Thr Ala Phe Leu Pro Ser Lys Tyr His Gly Tyr Glu Glu 
                165                 170                 175     


Leu Leu Thr Ala Lys Pro Asp Pro Ala Phe Ile Glu Pro Lys Gly Ile 
            180                 185                 190         


Gln Lys Asn Ala Gln Ala Leu Gln Gln Met Leu Lys His Pro Leu Leu 
        195                 200                 205             


Cys His Ser Ser Lys Pro Lys Leu Asp Thr Leu Gln Lys Pro Tyr Val 
    210                 215                 220                 


His Lys Glu Lys Arg Val Leu Ser Cys Thr Ser Gly Gln Asn Gly Gly 
225                 230                 235                 240 


Trp 
    

<210>  2774
<211>  923
<212>  DNA
<213>  Homo sapiens

<400>  2774
aaggcataaa caagagaaag cagcactgtc tgaaaagcaa cttgcttaaa atttccactg     60

ccaagagacc agatggtttc tgggacgtct agttaggcta aaaatacccg cacccacaat    120

gagtttgatt tacaaacaaa ggaaagcagg gttagccagt ataaacatgc agctggaaag    180

ctagaagatt taatgcttac aaaacactgc ttaaagggtg tcaaatggcc atacaagata    240

taaaacgtta gacagcttat gcgctcaatt gcttgctcat tactctctct gtctcttaca    300

tacctacgcc atacttgttt cttaagggta ccttcaggtc tgacagagct gagtcccacc    360

aagaaattaa ggttggagag gaccctcctg ccagtctctg gcctgaaaga cccttcccac    420

cctctccatc ctgtcacaca cacacacacc tctctctctc tctcactcac tcacacacac    480

acaccctgga gtgaaaccca gaagcttctt tagaccttgg tgcagctgct atccacccag    540

aagttggtaa tattttgtta cactctgggt tatctgcctt gtctatacta gtattctttt    600

tattttttta ggtgtacgat gtaatggttt ttagtatatt cagttattta accatcacca    660

caattaattt tagaacattt ctgtcacctc aaaaaggaac cctataccct ttagctatca    720

cctcaaaccc cacttcctcc agccctaagg aactactcat gtattttatg tctctacgta    780

tttgcctatt tggagtgcag tggcgggatc tcggctcact gcaagctccg cctcccgggt    840

tcacgccatt ctcctgcctc agcctcccag gtagctggga ctacaggcgc ccgccactac    900

gcccggctaa ttttttgtat ttt                                            923


<210>  2775
<211>  99
<212>  PRT
<213>  Homo sapiens

<400>  2775


Met Val Phe Ser Ile Phe Ser Tyr Leu Thr Ile Thr Thr Ile Asn Phe 
1               5                   10                  15      


Arg Thr Phe Leu Ser Pro Gln Lys Gly Thr Leu Tyr Pro Leu Ala Ile 
            20                  25                  30          


Thr Ser Asn Pro Thr Ser Ser Ser Pro Lys Glu Leu Leu Met Tyr Phe 
        35                  40                  45              


Met Ser Leu Arg Ile Cys Leu Phe Gly Val Gln Trp Arg Asp Leu Gly 
    50                  55                  60                  


Ser Leu Gln Ala Pro Pro Pro Gly Phe Thr Pro Phe Ser Cys Leu Ser 
65                  70                  75                  80  


Leu Pro Gly Ser Trp Asp Tyr Arg Arg Pro Pro Leu Arg Pro Ala Asn 
                85                  90                  95      


Phe Leu Tyr 
            

<210>  2776
<211>  1110
<212>  DNA
<213>  Homo sapiens

<400>  2776
ggagcggcag atcaaaaaga ccctttcaaa agccactctt acctctctgg ctcctgaaat     60

gggggaagag ttactaggct ctgaaggtat ccattctagc aaggagaagc cacttgtggc    120

tgtaaataca agattatctg gtgggcaggt cctctctgag tatactggac ccacctctgc    180

tgatcttgat catttcccct ctgttagcca aacaaaagca gaacaggaca gtgataataa    240

aagtagcact gagatcccac tggaaacctg ctgttcctca gaactcaaag ggggaggcag    300

tgggacttct ttggagaggg agcagtttga ggggttaggg tcaactccag atgccaagtt    360

agacaaaacc tgtataagca gagccatgaa aatcaccaca gttaattcag tgctacccca    420

aaacagtgtt ttgggtggag tcctcaaaac aaagcaacaa ttgaagacat taaatcattt    480

tgatctgact aatggtgttc tagttgagag cctaagtgaa gagccacttc cttctttgcg    540

tcgaggccgg aaaagacact gcaagaccaa gcacttagaa caaaatggct cccttaaaaa    600

actgcgacaa accagtgggg aggtgggtct ggccccaaca gacccagtcc tgcgagagat    660

ggagcagaag cttcagcaag aggaagaaga ccgacagttg gctctgcagt tgcagcgcat    720

gttcgacaat gagaggcgga ctgtgagccg gcgaaaagga agtgtggatc agtatctcct    780

acggtccagc aacatggccg gggccaagta gcacctaatg aagtgttacc tatttttaaa    840

aggattggag aaggtacctg gatccttgtg gactgccact gctggctgcc tcctctccaa    900

ctcatcagaa gagcattttg acaaagacag aggacttgga ccagggcatg ccctgttggg    960

gatgtttctg tcagcaagga catggcatgg aatcaagtgg gctgatgtgt tgttatttaa   1020

acagtaccaa agtgcattct tcaatgtatg tttgcctgct tgaagcaagg cccaagttga   1080

gaatacagta aaggaaactc atgaaagtgg                                    1110


<210>  2777
<211>  81
<212>  PRT
<213>  Homo sapiens

<400>  2777


Met Lys Cys Tyr Leu Phe Leu Lys Gly Leu Glu Lys Val Pro Gly Ser 
1               5                   10                  15      


Leu Trp Thr Ala Thr Ala Gly Cys Leu Leu Ser Asn Ser Ser Glu Glu 
            20                  25                  30          


His Phe Asp Lys Asp Arg Gly Leu Gly Pro Gly His Ala Leu Leu Gly 
        35                  40                  45              


Met Phe Leu Ser Ala Arg Thr Trp His Gly Ile Lys Trp Ala Asp Val 
    50                  55                  60                  


Leu Leu Phe Lys Gln Tyr Gln Ser Ala Phe Phe Asn Val Cys Leu Pro 
65                  70                  75                  80  


Ala 
    

<210>  2778
<211>  5347
<212>  DNA
<213>  Homo sapiens

<400>  2778
ccctagtatt tgatgtaggc tacatatcca gcatggaaaa aagaggaaaa actcttagct     60

cttaaacacg caacagtgat ggtggaattt cagacaggag gggcaaggta ctctgtgcat    120

gagtaggtat tattacaggg tcaaggcatc acccagcagt gagtcccatc cacagcagca    180

tgtcttaccc aataccaccc ccaatcctag caagcatgta gccctgcagt gaggggccta    240

gacatacctg ggtagaggtg aggggtggtg tcaacctgag agtctctcct gcattcatta    300

cagatcgcaa aagaggatgc tgtcctacca gtagctctct tcccatctct ctgcgagttc    360

gtctttcata acaaccctct ggtggcccat acacgaggtg aaaagcgaaa tcccaaaggt    420

gccgaagcag cctctggtgc tccatcaccc gcgcatgacg acaaccaagt ctccctcaaa    480

ggatatgcta gagccagagg cagagctggc tgaagatctg cccactacca aaagcacttc    540

tgtggagtca gagatgccca ctgagaacct ggaaggccat tccccgtctt gccggacctt    600

cgtgccactg cctcccatct gctccaactc cactgtgcat agtgaagaga ccctgtccca    660

cctgagtgac acaactgtcc gcctcagccc agagcgccca tcagatgagg actccaagag    720

cacagagtcc atcttcctga cccaggtgag tgaactgcct tcctccgtca tccataagga    780

tgatttagag ttaaaggaga aagaccaaaa gaaaccacca acggcaccca gagaggtgaa    840

agggactcgg aggaaactcc caactgcctt ccttcccagc aagtaccacg gctatgaaga    900

actgctgaca gccaagcctg atccagcctt cattgagcca aagggaatcc agaagaatgc    960

acaagccctg caacaaatgc tgaagcaccc actcctgtgc cactcctcca agcccaagct   1020

ggacactctt cagaaaccct atgttcacaa agagaaacgg gcccagagaa tcccgattcc   1080

acccccaaag aagactagag cccaacttct ggatgacatc ttcattcgct tgcgggatcc   1140

ccggaacatt acagaggctc cactaggtgc tgtcctgcac cagtggacag aacggcggct   1200

ggtgaaccac aagcagtacc tggaggccaa gaggctgttg aaggagttcc aggcacgtta   1260

ccggcagctg gtgagtggct ctctgcgcac agtgttcggg actaccccgc tccccatggc   1320

ctgcccagcg ctgagtgaga gccagcccaa gttcggccac ttcctcgagt tcatggatga   1380

gttctgccag gagcccacag ccagtgactc acaaggctag agctgtgcat gggggctgtg   1440

tgcaccaccc ggcctgtgcc ccagctctcc ccgagggctc tgtgccctgg accgcacctc   1500

aaggttgacc agccggccac aggcctcaga gctcagctgg gccccacttg ctggccacaa   1560

ggtggcatcc ccttgtcagg atctcccctc cttggcccag gcatgacctg gtgcctggcc   1620

cagcggcaat aaagagtggg tgcacagggc aatagactgg gtgccacatg cattctttct   1680

tggaacccag gccacagcag cattgtcaca cttccctcta aaaatggttt tccagttcag   1740

atgcaacagg gatacatttg ttctctgttg tatgagaaac tgacaccaag gggatcttaa   1800

caaattcctg aacaatggct ccaaaaaagg gtatttttaa aaaccagatc ttgtgagtac   1860

agccctaatg tgcagggaca gtgtcatcct gtatattcgt tctttactca gactctttct   1920

tggttccttc attaggagca tgaatggttg aatgtgaaca tgacagtaaa ttggagcaaa   1980

ctgtaaactg gacataactt atgccaaaag acgtagttgt acaccatgga aaccccatcc   2040

ctgctcctaa tctctactgc cattctgaat gccaaagcaa gacatccaac atggggcatc   2100

tcccagagca catacagcac caaaaatcca cacacagcct aagcttaacc catgtttttg   2160

tctgagattg ttcaccagag acaagactct gactataaac agaacatcca ctttcatgag   2220

tttcctttac tgtattctca acttgggcct tgcttcaagc aggcaaacat acattgaaga   2280

atgcactttg gtactgttta aataacaaca catcagccca cttgattcca tgccatgtcc   2340

ttgctgacag aaacatcccc aacagggcat gccctggtcc aagtcctctg tctttgtcaa   2400

aatgctcttc tgatgagttg gagaggaggc agccagcagt ggcagtccac aaggatccag   2460

gtaccttctc caatcctaaa gcagacagca ggttgaataa aaccaataca caacctattt   2520

tctaggcagg aggggaaaag gcccttagga caataatatt tgtacaaaga gttgagagta   2580

aacaaacagt gtatcaggtt caaaaaaaaa aaaactattc gttggcattt aaattttttt   2640

cccttgcata gtatctattc tctcactagg acttttaagt gctctgctgg aggctcagcg   2700

ttggtaatac catgtttgat gcaaacttga acccaatgct ctcattggtg gcacagcttt   2760

ggagggtggt ggccccaaga aggggcaatc tgcctgctgc tatattaatc tggaaccagg   2820

gccaacagct actcttgaac tatggtattt gaagagcgag ttcattgcct gttttacctt   2880

aaatgacagg aaaggaagat gaacaaacct tgctttgcct tggcttcaaa ctagttcttg   2940

atttaagaca ccagaaaggg agagagggag tctgcttaga gtttgaggtt gcctctcaca   3000

agatgacagt taaaagttgc caccttactt aaaaggcatt aaggaggcat ttactcacaa   3060

aggagagaga gtaaattttt ttcttaagag gaaaaaaata ctgataatac atagaacaat   3120

ctgcacatcc agtcttggca ctttttccaa tttgactgat ctctaaactg gtgacccttg   3180

catatatctt agtctctttt ctacaatctt cttcagaaag ctacagcagc taacaatcat   3240

gtataaagat gcatttccta gatcatcttc agaagaaaat ctcttcagca ctttccctag   3300

aatctgtctc ctgaccaccc cgccccagac ctgctttctc ttttgagaat tcataaccag   3360

gtatgtttag ataccagttc aaaagaccac tctatgggtt gatgaggaaa aggctgcctg   3420

aggacaattt aagaccataa tgagtttcca atttttaaag aaaatttggc tagctggctt   3480

ttaattctta attaaaatca ttaaatttaa ttaaaattat tccaatcaaa atatatcact   3540

ttccaagatt ccacattcat attacttact tatactatgg agactttctc tacctgagca   3600

tgtattcagg ggctataggt acatttaact ctaactaact gaaaaaaatc aggaagaaaa   3660

aactattaaa ataaaataac ctcctaaatc atttgggggt atccccatca ttggtgcgtg   3720

tgtctgcgtg tgtcaaactt taatgattat ttattcagac cctggaaaac cacactataa   3780

aatagggcac tggatcacaa gttcgtttgg ttaaaaaaaa aaaaaaaaaa aagtgggggc   3840

ggggggcaga gaagaagttt aacttggatg atttccatgc ccattccagc tgtaacattc   3900

tatgactgtg acccagcctt tgttctcttt tctcactctc ctactagaca tttcaatgaa   3960

aagttaggca ggaaaaagga aaggaatccc aagttgctgc cagctctgat gagagatcag   4020

gttgggggag agattaggtg gttactgaat tgaggtgtgg gcctcccctg accatgtcag   4080

tgatccacaa cccacctcac ttcttggggc ttaagctaaa agcagcttct gaagagatgt   4140

taatgtcctg taatcactag aggagaaaat tcattctcct tccataacat tacttagtaa   4200

aggaaaagcg gtggtgcaat caaattcaca aataccaatg gggtctctaa aatgtagaat   4260

gcagcttgct gggtgctggt cagttttcta aatgggacca gaaatggctt tcctaagacc   4320

ataaatgaac tctccagcca cacatacatt caaatgcatt ccattagaca ttgagctcct   4380

caagagcagg aactgcttta tctccacagt ccagctcagg gttggctcaa gtctgaagct   4440

cagtaaatgt ctgtcaaata gaaaagaaag gatgagcctt cggtcatcag ctacatgagt   4500

caggcacggt ggcagcttcc cattttagtc agtttgccag tttgtaacca gacagtaatc   4560

aattaagagc tttaatctct taaggacatt tttcctttag ggaaaatgaa caaaaaataa   4620

aacatttatt accagtgctg cttccaagca aaaatttaaa aattaaatta aaatttaaaa   4680

aataagtgaa gccacttagg agtttccctg gcaagcctca cccaagaaga cttaaccttt   4740

tttaaaaaga ggcaaataga ttaaaggggc caggggctgg atgcataatc ccctgatctg   4800

ataccaaccc aacaggccca gatgacttct tccagcagat acaatcaatg ggtcaagaac   4860

attttctcaa agtttctttc cctctctatg gaaaagagct gacagccccc ttctaagggc   4920

accacatttc ctggatttcc cctcagactg accttcaccc tcccccctaa cttccccttt   4980

aataataaaa aaacccagaa tgcatatata caaggaacag agtaagacat gggtaatttg   5040

tatggtgaac tgggcttcaa tgatttgtga ggaatttgtt ttgtgaaatc ctgcacctct   5100

tattctagct cacaaaccct tcccatcgtt ctgtttcctt ccttgtcctt ttctgttccc   5160

ccaaataata cacatcaaca tatcgacttt taaccaactt cagaatcatg gaaggagaga   5220

gggagatttt tcagaaagaa aagcattcag gttttagtta ttaaggatgg gaagcatctt   5280

aaaattcaga taatacctta gtggtttttc cttcctccaa agccaacctg attaaagatc   5340

aaccctc                                                             5347


<210>  2779
<211>  321
<212>  PRT
<213>  Homo sapiens

<400>  2779


Met Thr Thr Thr Lys Ser Pro Ser Lys Asp Met Leu Glu Pro Glu Ala 
1               5                   10                  15      


Glu Leu Ala Glu Asp Leu Pro Thr Thr Lys Ser Thr Ser Val Glu Ser 
            20                  25                  30          


Glu Met Pro Thr Glu Asn Leu Glu Gly His Ser Pro Ser Cys Arg Thr 
        35                  40                  45              


Phe Val Pro Leu Pro Pro Ile Cys Ser Asn Ser Thr Val His Ser Glu 
    50                  55                  60                  


Glu Thr Leu Ser His Leu Ser Asp Thr Thr Val Arg Leu Ser Pro Glu 
65                  70                  75                  80  


Arg Pro Ser Asp Glu Asp Ser Lys Ser Thr Glu Ser Ile Phe Leu Thr 
                85                  90                  95      


Gln Val Ser Glu Leu Pro Ser Ser Val Ile His Lys Asp Asp Leu Glu 
            100                 105                 110         


Leu Lys Glu Lys Asp Gln Lys Lys Pro Pro Thr Ala Pro Arg Glu Val 
        115                 120                 125             


Lys Gly Thr Arg Arg Lys Leu Pro Thr Ala Phe Leu Pro Ser Lys Tyr 
    130                 135                 140                 


His Gly Tyr Glu Glu Leu Leu Thr Ala Lys Pro Asp Pro Ala Phe Ile 
145                 150                 155                 160 


Glu Pro Lys Gly Ile Gln Lys Asn Ala Gln Ala Leu Gln Gln Met Leu 
                165                 170                 175     


Lys His Pro Leu Leu Cys His Ser Ser Lys Pro Lys Leu Asp Thr Leu 
            180                 185                 190         


Gln Lys Pro Tyr Val His Lys Glu Lys Arg Ala Gln Arg Ile Pro Ile 
        195                 200                 205             


Pro Pro Pro Lys Lys Thr Arg Ala Gln Leu Leu Asp Asp Ile Phe Ile 
    210                 215                 220                 


Arg Leu Arg Asp Pro Arg Asn Ile Thr Glu Ala Pro Leu Gly Ala Val 
225                 230                 235                 240 


Leu His Gln Trp Thr Glu Arg Arg Leu Val Asn His Lys Gln Tyr Leu 
                245                 250                 255     


Glu Ala Lys Arg Leu Leu Lys Glu Phe Gln Ala Arg Tyr Arg Gln Leu 
            260                 265                 270         


Val Ser Gly Ser Leu Arg Thr Val Phe Gly Thr Thr Pro Leu Pro Met 
        275                 280                 285             


Ala Cys Pro Ala Leu Ser Glu Ser Gln Pro Lys Phe Gly His Phe Leu 
    290                 295                 300                 


Glu Phe Met Asp Glu Phe Cys Gln Glu Pro Thr Ala Ser Asp Ser Gln 
305                 310                 315                 320 


Gly 
    

<210>  2780
<211>  6818
<212>  DNA
<213>  Homo sapiens

<400>  2780
ttacagcttt gttagtagct ttgcttccac aacaatctgc ttttgtttca ggagtgaaac     60

ttttgaattt ctcagaggat actaattatt ctattttgaa gtttttataa cttttgttaa    120

ataaactgtt tttattcagg tgataattct tccctttttt atattgttaa ttttcctcaa    180

atagtaggag attcttgatt attcagtctt tttgtgtaac aatcctcaat cagaagctta    240

aaatgcagta attcctgtga ttgtggggag agcaggatgc gcgttcagac agcgtgccca    300

tctttctaga ggtgctgttg ttttctaggg ttcattgctt agcactcaca cttgcaacca    360

tggcccatcc cccagggaat tcctactttg ttcattgcac aaagctttcc caaactccct    420

tgcagaccct catcacagga gaagttattt atgccatgtt gttccatctc ctattactgt    480

tttcttcatt ttcatgtgac ttgtctcatt ataatatcat taacatgtag aaggtgtcgg    540

ttaactaggg taaaggtgag caatgtctgc acaggatcta gtcccagcag atgctatgct    600

gtgttaggtt gaactcagct gttagactca tctcattctg acggtcccaa gaatgaaatc    660

actctgcagc ctcctcctta tgactgtgtg ctggttgttc ttggtatctc tcctgaattc    720

actggctcaa cacattctgt ttctactaat ataagaaata tttccaaatc ctctgacaga    780

atgtcttcta tatacatttt tctcttctaa gacagttggt tagctttctg ctcagtatgg    840

actccccagt aattctgagg ctcgaaagtg cttatgtgct ttaaagtcag attgaaggtc    900

agtcagtgtg gctgaaatac agtgaatgag ggagagtatc atgaaatgag actgaagaag    960

taggcagggg cccaatcatg caggacatca gaggactaga taagcagttt gtattttatc   1020

ctaagtgcaa agggacttat tacctgatgc atgtcacagc cagctcctct tcctagttag   1080

cactggggct gaggaccaat gagaactccc tctaggaggt gccctgctgc acacagtgga   1140

tggcagacct atatcctggg tgctctaggc atcaatcagc ggtctcacca accttcattc   1200

tgtttctctt ctgtttcaga ggttgtgttt tcatcttacc ctggattttc aacctcagag   1260

gtgaaaagcg aaatcccaaa ggtgccgaag cagcctctgg tgctccatca cccgcgcatg   1320

acgacaacca agtctccctc aaaggatatg ctagagccag aggcagagct ggctgaagat   1380

ctgcccacta ccaaaagcac ttctgtggag tcagagatgc ccactgagaa cctggaaggc   1440

cattccccgt cttgccggac cttcgtgcca ctgcctccca tctgctccaa ctccactgtg   1500

catagtgaag agaccctgtc ccacctgagt gacacaactg tccgcctcag cccagagcgc   1560

ccatcagatg aggactccaa gagcacagag tccatcttcc tgacccaggt gagtgaactg   1620

ccttcctccg tcatccataa ggatgattta gagttaaagg agaaagacca aaagaaacca   1680

ccaacggcac ccagagaggt gaaagggact cggaggaaac tcccaactgc cttccttccc   1740

agcaagtacc acggctatga agaactgctg acagccaagc ctgatccagc cttcattgag   1800

ccaaagggaa tccagaagaa tgcacaagcc ctgcaacaaa tgctgaagca cccactcctg   1860

tgccactcct ccaagcccaa gctggacact cttcagaaac cctatgttca caaagagaaa   1920

cgggtaaaca tccagctcac tgaatgtgta aatggcccct gagtaccgcc cacaattaca   1980

gatgtggctg tcaccttggg accctctgag ggccatgctt tcccagcacc cccagatgcc   2040

ccccagcctg ttgctgtgac tgtatgaagt taggccaggg aagtctgtgc ataaacctgg   2100

gataacaccc tcctccatga ccttctgcca ggcccagaga atcccgattc cacccccaaa   2160

gaagactaga gcccaacttc tggatgacat cttcattcgc ttgcgggatc cccggaacat   2220

tacagaggct ccactaggta cggctctgcc acagctgcca ggatcccaga tccagttcac   2280

gcctgctggc taaaggcaaa gaaagggctt gtgtcagtgc aggaaaggcc cttagagagc   2340

aactgcctac atcagtctct acatgtagat ggacaaaagg agagccagcg tgaggcaggg   2400

agttgcctaa aatcacacag catgttaagg tcctgaacca gggcttaaga tagagtcaat   2460

gcataggggc agtaggaagt cagtgacttc ccaagctgga aaggccattt ttagcccctt   2520

agcatcctcc tgccacacca tcccattttc caagggtctc tggacccaat cctcttgctt   2580

ctggctaggt gagaaccagg atgagcttgg tgcctctcct ggcttctttt cctgcaggtg   2640

ctgtcctgca ccagtggaca gaacggcggc tggtgaacca caagcagtac ctggaggcca   2700

agaggctgtt gaaggagttc caggcacgtt accggcagct ggtgagtggc tctctgcgca   2760

cagtgttcgg gactaccccg ctccccatgg cctgcccagc gctgagtgag agccagccca   2820

agttcggcca cttcctcgag ttcatggatg agttctgcca ggagcccaca gccagtgact   2880

cacaaggcta gagctgtgca tgggggctgt gtgcaccacc cggcctgtgc cccagctctc   2940

cccgagggct ctgtgccctg gaccgcacct caaggttgac cagccggcca caggcctcag   3000

agctcagctg ggccccactt gctggccaca aggtggcatc cccttgtcag gatctcccct   3060

ccttggccca ggcatgacct ggtgcctggc ccagcggcaa taaagagtgg gtgcacaggg   3120

caatagactg ggtgccacat gcattctttc ttggaaccca ggccacagca gcattgtcac   3180

acttccctct aaaaatggtt ttccagttca gatgcaacag ggatacattt gttctctgtt   3240

gtatgagaaa ctgacaccaa ggggatctta acaaattcct gaacaatggc tccaaaaaag   3300

ggtattttta aaaaccagat cttgtgagta cagccctaat gtgcagggac agtgtcatcc   3360

tgtatattcg ttctttactc agactctttc ttggttcctt cattaggagc atgaatggtt   3420

gaatgtgaac atgacagtaa attggagcaa actgtaaact ggacataact tatgccaaaa   3480

gacgtagttg tacaccatgg aaaccccatc cctgctccta atctctactg ccattctgaa   3540

tgccaaagca agacatccaa catggggcat ctcccagagc acatacagca ccaaaaatcc   3600

acacacagcc taagcttaac ccatgttttt gtctgagatt gttcaccaga gacaagactc   3660

tgactataaa cagaacatcc actttcatga gtttccttta ctgtattctc aacttgggcc   3720

ttgcttcaag caggcaaaca tacattgaag aatgcacttt ggtactgttt aaataacaac   3780

acatcagccc acttgattcc atgccatgtc cttgctgaca gaaacatccc caacagggca   3840

tgccctggtc caagtcctct gtctttgtca aaatgctctt ctgatgagtt ggagaggagg   3900

cagccagcag tggcagtcca caaggatcca ggtaccttct ccaatcctaa agcagacagc   3960

aggttgaata aaaccaatac acaacctatt ttctaggcag gaggggaaaa ggcccttagg   4020

acaataatat ttgtacaaag agttgagagt aaacaaacag tgtatcaggt tcaaaaaaaa   4080

aaaaactatt cgttggcatt taaatttttt tcccttgcat agtatctatt ctctcactag   4140

gacttttaag tgctctgctg gaggctcagc gttggtaata ccatgtttga tgcaaacttg   4200

aacccaatgc tctcattggt ggcacagctt tggagggtgg tggccccaag aaggggcaat   4260

ctgcctgctg ctatattaat ctggaaccag ggccaacagc tactcttgaa ctatggtatt   4320

tgaagagcga gttcattgcc tgttttacct taaatgacag gaaaggaaga tgaacaaacc   4380

ttgctttgcc ttggcttcaa actagttctt gatttaagac accagaaagg gagagaggga   4440

gtctgcttag agtttgaggt tgcctctcac aagatgacag ttaaaagttg ccaccttact   4500

taaaaggcat taaggaggca tttactcaca aaggagagag agtaaatttt tttcttaaga   4560

ggaaaaaaat actgataata catagaacaa tctgcacatc cagtcttggc actttttcca   4620

atttgactga tctctaaact ggtgaccctt gcatatatct tagtctcttt tctacaatct   4680

tcttcagaaa gctacagcag ctaacaatca tgtataaaga tgcatttcct agatcatctt   4740

cagaagaaaa tctcttcagc actttcccta gaatctgtct cctgaccacc ccgccccaga   4800

cctgctttct cttttgagaa ttcataacca ggtatgttta gataccagtt caaaagacca   4860

ctctatgggt tgatgaggaa aaggctgcct gaggacaatt taagaccata atgagtttcc   4920

aatttttaaa gaaaatttgg ctagctggct tttaattctt aattaaaatc attaaattta   4980

attaaaatta ttccaatcaa aatatatcac tttccaagat tccacattca tattacttac   5040

ttatactatg gagactttct ctacctgagc atgtattcag gggctatagg tacatttaac   5100

tctaactaac tgaaaaaaat caggaagaaa aaactattaa aataaaataa cctcctaaat   5160

catttggggg tatccccatc attggtgcgt gtgtctgcgt gtgtcaaact ttaatgatta   5220

tttattcaga ccctggaaaa ccacactata aaatagggca ctggatcaca agttcgtttg   5280

gttaaaaaaa aaaaaaaaaa aaagtggggg cggggggcag agaagaagtt taacttggat   5340

gatttccatg cccattccag ctgtaacatt ctatgactgt gacccagcct ttgttctctt   5400

ttctcactct cctactagac atttcaatga aaagttaggc aggaaaaagg aaaggaatcc   5460

caagttgctg ccagctctga tgagagatca ggttggggga gagattaggt ggttactgaa   5520

ttgaggtgtg ggcctcccct gaccatgtca gtgatccaca acccacctca cttcttgggg   5580

cttaagctaa aagcagcttc tgaagagatg ttaatgtcct gtaatcacta gaggagaaaa   5640

ttcattctcc ttccataaca ttacttagta aaggaaaagc ggtggtgcaa tcaaattcac   5700

aaataccaat ggggtctcta aaatgtagaa tgcagcttgc tgggtgctgg tcagttttct   5760

aaatgggacc agaaatggct ttcctaagac cataaatgaa ctctccagcc acacatacat   5820

tcaaatgcat tccattagac attgagctcc tcaagagcag gaactgcttt atctccacag   5880

tccagctcag ggttggctca agtctgaagc tcagtaaatg tctgtcaaat agaaaagaaa   5940

ggatgagcct tcggtcatca gctacatgag tcaggcacgg tggcagcttc ccattttagt   6000

cagtttgcca gtttgtaacc agacagtaat caattaagag ctttaatctc ttaaggacat   6060

ttttccttta gggaaaatga acaaaaaata aaacatttat taccagtgct gcttccaagc   6120

aaaaatttaa aaattaaatt aaaatttaaa aaataagtga agccacttag gagtttccct   6180

ggcaagcctc acccaagaag acttaacctt ttttaaaaag aggcaaatag attaaagggg   6240

ccaggggctg gatgcataat cccctgatct gataccaacc caacaggccc agatgacttc   6300

ttccagcaga tacaatcaat gggtcaagaa cattttctca aagtttcttt ccctctctat   6360

ggaaaagagc tgacagcccc cttctaaggg caccacattt cctggatttc ccctcagact   6420

gaccttcacc ctccccccta acttcccctt taataataaa aaaacccaga atgcatatat   6480

acaaggaaca gagtaagaca tgggtaattt gtatggtgaa ctgggcttca atgatttgtg   6540

aggaatttgt tttgtgaaat cctgcacctc ttattctagc tcacaaaccc ttcccatcgt   6600

tctgtttcct tccttgtcct tttctgttcc cccaaataat acacatcaac atatcgactt   6660

ttaaccaact tcagaatcat ggaaggagag agggagattt ttcagaaaga aaagcattca   6720

ggttttagtt attaaggatg ggaagcatct taaaattcag ataatacctt agtggttttt   6780

ccttcctcca aagccaacct gattaaagat caaccctc                           6818


<210>  2781
<211>  287
<212>  PRT
<213>  Homo sapiens

<400>  2781


Met Arg Thr Pro Ser Arg Arg Cys Pro Ala Ala His Ser Gly Trp Gln 
1               5                   10                  15      


Thr Tyr Ile Leu Gly Ala Leu Gly Ile Asn Gln Arg Ser His Gln Pro 
            20                  25                  30          


Ser Phe Cys Phe Ser Ser Val Ser Glu Val Val Phe Ser Ser Tyr Pro 
        35                  40                  45              


Gly Phe Ser Thr Ser Glu Val Lys Ser Glu Ile Pro Lys Val Pro Lys 
    50                  55                  60                  


Gln Pro Leu Val Leu His His Pro Arg Met Thr Thr Thr Lys Ser Pro 
65                  70                  75                  80  


Ser Lys Asp Met Leu Glu Pro Glu Ala Glu Leu Ala Glu Asp Leu Pro 
                85                  90                  95      


Thr Thr Lys Ser Thr Ser Val Glu Ser Glu Met Pro Thr Glu Asn Leu 
            100                 105                 110         


Glu Gly His Ser Pro Ser Cys Arg Thr Phe Val Pro Leu Pro Pro Ile 
        115                 120                 125             


Cys Ser Asn Ser Thr Val His Ser Glu Glu Thr Leu Ser His Leu Ser 
    130                 135                 140                 


Asp Thr Thr Val Arg Leu Ser Pro Glu Arg Pro Ser Asp Glu Asp Ser 
145                 150                 155                 160 


Lys Ser Thr Glu Ser Ile Phe Leu Thr Gln Val Ser Glu Leu Pro Ser 
                165                 170                 175     


Ser Val Ile His Lys Asp Asp Leu Glu Leu Lys Glu Lys Asp Gln Lys 
            180                 185                 190         


Lys Pro Pro Thr Ala Pro Arg Glu Val Lys Gly Thr Arg Arg Lys Leu 
        195                 200                 205             


Pro Thr Ala Phe Leu Pro Ser Lys Tyr His Gly Tyr Glu Glu Leu Leu 
    210                 215                 220                 


Thr Ala Lys Pro Asp Pro Ala Phe Ile Glu Pro Lys Gly Ile Gln Lys 
225                 230                 235                 240 


Asn Ala Gln Ala Leu Gln Gln Met Leu Lys His Pro Leu Leu Cys His 
                245                 250                 255     


Ser Ser Lys Pro Lys Leu Asp Thr Leu Gln Lys Pro Tyr Val His Lys 
            260                 265                 270         


Glu Lys Arg Val Asn Ile Gln Leu Thr Glu Cys Val Asn Gly Pro 
        275                 280                 285         

<210>  2782
<211>  6254
<212>  DNA
<213>  Homo sapiens

<400>  2782
ccccgggggg ctcgcaggcg cgcatccctc ctgactggga cgtcgcctcc gcagacccct     60

cggaggctga agcgacgccg gaggcaggga gatggccttc tcaggaatct acaagctgga    120

tgatgggaag ccttacctga acaactgctt cccagccaga aatctgcttc gcgtgccgga    180

ggaaggccaa ggacactggt tagtggttca gaaaggtaac ctcaagaaga agcccaaggg    240

tttggttgga gcacaagctg aacgtcggga aagcctgaag gcgacttctt ttgagttcaa    300

ggggaagaaa gagtctcggc gggaaaatca ggtggacctt cctggacata tcctggacca    360

ggcttttctg ctgaagcacc actgtgtgag gaagccatca gatctgtgca ccattaatgt    420

gagtggcctg aagttctcca aggccaagga aaatgacttc aagcattttc attctgtgat    480

ttatatcaat gcctcagaaa acctgctgcc tctagaggca tttcacacgt ttccagccct    540

aaaggaactg gatctcgcat ttaatggcat caaaactatc tacgtgaaat atggagactt    600

taagttatta gaattcttgg acctttcctt caacagcctg actgtggagg ccatctgtga    660

tttggggatt ctgccacacc tccgtgtcct gctcctcaca ggcaatggcc ttacctccct    720

gccgcccaat ttggccgtcg cagaacagga ggcatctgta acatcgctga caagcaagag    780

gtacatcctg aggttcccag cgctggagac actgatgctg gatgacaaca gactctccaa    840

ccccagttgc tttgccagcc tggctgggct caggagactg aagaagttaa gcttggatga    900

aaacaggatt atcaggatcc catacctaca gcaagttcag ctctatgacg agtcagtaga    960

ctggaatgga ggcaggggaa gtccccataa agagccccaa ttcatgctgc agtccaagcc   1020

aaggatgctt gaggactcag atgagcaact ggattatact gtactgccca tgaaaaagga   1080

tgttgaccgg acagatcgca aaagaggatg ctgtcctacc agtagctctc ttcccatctc   1140

tctgcgagtt cgtctttcat aacaaccctc tggtggccca tacacgaggg gtccctccac   1200

tgctgaagag cttcctccag gagcgactgg gaatccactt aattcgaagg aagatagtaa   1260

agcctaagca tcatgttttg atgtctcgga aggaatcatg gaaggtgaaa agcgaaatcc   1320

caaaggtgcc gaagcagcct ctggtgctcc atcacccgcg catgacgaca accaagtctc   1380

cctcaaagga tatgctagag ccagaggcag agctggctga agatctgccc actaccaaaa   1440

gcacttctgt ggagtcagag atgcccactg agaacctgga aggccattcc ccgtcttgcc   1500

ggaccttcgt gccactgcct cccatctgct ccaactccac tgtgcatagt gaagagaccc   1560

tgtcccacct gagtgacaca actgtccgcc tcagcccaga gcgcccatca gatgaggact   1620

ccaagagcac agagtccatc ttcctgaccc aggtgagtga actgccttcc tccgtcatcc   1680

ataaggatga tttagagtta aaggagaaag accaaaagaa accaccaacg gcacccagag   1740

aggtgaaagg gactcggagg aaactcccaa ctgccttcct tcccagcaag taccacggct   1800

atgaagaact gctgacagcc aagcctgatc cagccttcat tgagccaaag ggaatccaga   1860

agaatgcaca agccctgcaa caaatgctga agcacccact cctgtgccac tcctccaagc   1920

ccaagctgga cactcttcag aaaccctatg ttcacaaaga gaaacgggcc cagagaatcc   1980

cgattccacc cccaaagaag actagagccc aacttctgga tgacatcttc attcgcttgc   2040

gggatccccg gaacattaca gaggctccac taggtgctgt cctgcaccag tggacagaac   2100

ggcggctggt gaaccacaag cagtacctgg aggccaagag gctgttgaag gagttccagg   2160

cacgttaccg gcagctggtg agtggctctc tgcgcacagt gttcgggact accccgctcc   2220

ccatggcctg cccagcgctg agtgagagcc agcccaagtt cggccacttc ctcgagttca   2280

tggatgagtt ctgccaggag cccacagcca gtgactcaca aggctagagc tgtgcatggg   2340

ggctgtgtgc accacccggc ctgtgcccca gctctccccg agggctctgt gccctggacc   2400

gcacctcaag gttgaccagc cggccacagg cctcagagct cagctgggcc ccacttgctg   2460

gccacaaggt ggcatcccct tgtcaggatc tcccctcctt ggcccaggca tgacctggtg   2520

cctggcccag cggcaataaa gagtgggtgc acagggcaat agactgggtg ccacatgcat   2580

tctttcttgg aacccaggcc acagcagcat tgtcacactt ccctctaaaa atggttttcc   2640

agttcagatg caacagggat acatttgttc tctgttgtat gagaaactga caccaagggg   2700

atcttaacaa attcctgaac aatggctcca aaaaagggta tttttaaaaa ccagatcttg   2760

tgagtacagc cctaatgtgc agggacagtg tcatcctgta tattcgttct ttactcagac   2820

tctttcttgg ttccttcatt aggagcatga atggttgaat gtgaacatga cagtaaattg   2880

gagcaaactg taaactggac ataacttatg ccaaaagacg tagttgtaca ccatggaaac   2940

cccatccctg ctcctaatct ctactgccat tctgaatgcc aaagcaagac atccaacatg   3000

gggcatctcc cagagcacat acagcaccaa aaatccacac acagcctaag cttaacccat   3060

gtttttgtct gagattgttc accagagaca agactctgac tataaacaga acatccactt   3120

tcatgagttt cctttactgt attctcaact tgggccttgc ttcaagcagg caaacataca   3180

ttgaagaatg cactttggta ctgtttaaat aacaacacat cagcccactt gattccatgc   3240

catgtccttg ctgacagaaa catccccaac agggcatgcc ctggtccaag tcctctgtct   3300

ttgtcaaaat gctcttctga tgagttggag aggaggcagc cagcagtggc agtccacaag   3360

gatccaggta ccttctccaa tcctaaagca gacagcaggt tgaataaaac caatacacaa   3420

cctattttct aggcaggagg ggaaaaggcc cttaggacaa taatatttgt acaaagagtt   3480

gagagtaaac aaacagtgta tcaggttcaa aaaaaaaaaa actattcgtt ggcatttaaa   3540

tttttttccc ttgcatagta tctattctct cactaggact tttaagtgct ctgctggagg   3600

ctcagcgttg gtaataccat gtttgatgca aacttgaacc caatgctctc attggtggca   3660

cagctttgga gggtggtggc cccaagaagg ggcaatctgc ctgctgctat attaatctgg   3720

aaccagggcc aacagctact cttgaactat ggtatttgaa gagcgagttc attgcctgtt   3780

ttaccttaaa tgacaggaaa ggaagatgaa caaaccttgc tttgccttgg cttcaaacta   3840

gttcttgatt taagacacca gaaagggaga gagggagtct gcttagagtt tgaggttgcc   3900

tctcacaaga tgacagttaa aagttgccac cttacttaaa aggcattaag gaggcattta   3960

ctcacaaagg agagagagta aatttttttc ttaagaggaa aaaaatactg ataatacata   4020

gaacaatctg cacatccagt cttggcactt tttccaattt gactgatctc taaactggtg   4080

acccttgcat atatcttagt ctcttttcta caatcttctt cagaaagcta cagcagctaa   4140

caatcatgta taaagatgca tttcctagat catcttcaga agaaaatctc ttcagcactt   4200

tccctagaat ctgtctcctg accaccccgc cccagacctg ctttctcttt tgagaattca   4260

taaccaggta tgtttagata ccagttcaaa agaccactct atgggttgat gaggaaaagg   4320

ctgcctgagg acaatttaag accataatga gtttccaatt tttaaagaaa atttggctag   4380

ctggctttta attcttaatt aaaatcatta aatttaatta aaattattcc aatcaaaata   4440

tatcactttc caagattcca cattcatatt acttacttat actatggaga ctttctctac   4500

ctgagcatgt attcaggggc tataggtaca tttaactcta actaactgaa aaaaatcagg   4560

aagaaaaaac tattaaaata aaataacctc ctaaatcatt tgggggtatc cccatcattg   4620

gtgcgtgtgt ctgcgtgtgt caaactttaa tgattattta ttcagaccct ggaaaaccac   4680

actataaaat agggcactgg atcacaagtt cgtttggtta aaaaaaaaaa aaaaaaaaag   4740

tgggggcggg gggcagagaa gaagtttaac ttggatgatt tccatgccca ttccagctgt   4800

aacattctat gactgtgacc cagcctttgt tctcttttct cactctccta ctagacattt   4860

caatgaaaag ttaggcagga aaaaggaaag gaatcccaag ttgctgccag ctctgatgag   4920

agatcaggtt gggggagaga ttaggtggtt actgaattga ggtgtgggcc tcccctgacc   4980

atgtcagtga tccacaaccc acctcacttc ttggggctta agctaaaagc agcttctgaa   5040

gagatgttaa tgtcctgtaa tcactagagg agaaaattca ttctccttcc ataacattac   5100

ttagtaaagg aaaagcggtg gtgcaatcaa attcacaaat accaatgggg tctctaaaat   5160

gtagaatgca gcttgctggg tgctggtcag ttttctaaat gggaccagaa atggctttcc   5220

taagaccata aatgaactct ccagccacac atacattcaa atgcattcca ttagacattg   5280

agctcctcaa gagcaggaac tgctttatct ccacagtcca gctcagggtt ggctcaagtc   5340

tgaagctcag taaatgtctg tcaaatagaa aagaaaggat gagccttcgg tcatcagcta   5400

catgagtcag gcacggtggc agcttcccat tttagtcagt ttgccagttt gtaaccagac   5460

agtaatcaat taagagcttt aatctcttaa ggacattttt cctttaggga aaatgaacaa   5520

aaaataaaac atttattacc agtgctgctt ccaagcaaaa atttaaaaat taaattaaaa   5580

tttaaaaaat aagtgaagcc acttaggagt ttccctggca agcctcaccc aagaagactt   5640

aacctttttt aaaaagaggc aaatagatta aaggggccag gggctggatg cataatcccc   5700

tgatctgata ccaacccaac aggcccagat gacttcttcc agcagataca atcaatgggt   5760

caagaacatt ttctcaaagt ttctttccct ctctatggaa aagagctgac agcccccttc   5820

taagggcacc acatttcctg gatttcccct cagactgacc ttcaccctcc cccctaactt   5880

cccctttaat aataaaaaaa cccagaatgc atatatacaa ggaacagagt aagacatggg   5940

taatttgtat ggtgaactgg gcttcaatga tttgtgagga atttgttttg tgaaatcctg   6000

cacctcttat tctagctcac aaacccttcc catcgttctg tttccttcct tgtccttttc   6060

tgttccccca aataatacac atcaacatat cgacttttaa ccaacttcag aatcatggaa   6120

ggagagaggg agatttttca gaaagaaaag cattcaggtt ttagttatta aggatgggaa   6180

gcatcttaaa attcagataa taccttagtg gtttttcctt cctccaaagc caacctgatt   6240

aaagatcaac cctc                                                     6254


<210>  2783
<211>  415
<212>  PRT
<213>  Homo sapiens

<400>  2783


Met Leu Thr Gly Gln Ile Ala Lys Glu Asp Ala Val Leu Pro Val Ala 
1               5                   10                  15      


Leu Phe Pro Ser Leu Cys Glu Phe Val Phe His Asn Asn Pro Leu Val 
            20                  25                  30          


Ala His Thr Arg Gly Val Pro Pro Leu Leu Lys Ser Phe Leu Gln Glu 
        35                  40                  45              


Arg Leu Gly Ile His Leu Ile Arg Arg Lys Ile Val Lys Pro Lys His 
    50                  55                  60                  


His Val Leu Met Ser Arg Lys Glu Ser Trp Lys Val Lys Ser Glu Ile 
65                  70                  75                  80  


Pro Lys Val Pro Lys Gln Pro Leu Val Leu His His Pro Arg Met Thr 
                85                  90                  95      


Thr Thr Lys Ser Pro Ser Lys Asp Met Leu Glu Pro Glu Ala Glu Leu 
            100                 105                 110         


Ala Glu Asp Leu Pro Thr Thr Lys Ser Thr Ser Val Glu Ser Glu Met 
        115                 120                 125             


Pro Thr Glu Asn Leu Glu Gly His Ser Pro Ser Cys Arg Thr Phe Val 
    130                 135                 140                 


Pro Leu Pro Pro Ile Cys Ser Asn Ser Thr Val His Ser Glu Glu Thr 
145                 150                 155                 160 


Leu Ser His Leu Ser Asp Thr Thr Val Arg Leu Ser Pro Glu Arg Pro 
                165                 170                 175     


Ser Asp Glu Asp Ser Lys Ser Thr Glu Ser Ile Phe Leu Thr Gln Val 
            180                 185                 190         


Ser Glu Leu Pro Ser Ser Val Ile His Lys Asp Asp Leu Glu Leu Lys 
        195                 200                 205             


Glu Lys Asp Gln Lys Lys Pro Pro Thr Ala Pro Arg Glu Val Lys Gly 
    210                 215                 220                 


Thr Arg Arg Lys Leu Pro Thr Ala Phe Leu Pro Ser Lys Tyr His Gly 
225                 230                 235                 240 


Tyr Glu Glu Leu Leu Thr Ala Lys Pro Asp Pro Ala Phe Ile Glu Pro 
                245                 250                 255     


Lys Gly Ile Gln Lys Asn Ala Gln Ala Leu Gln Gln Met Leu Lys His 
            260                 265                 270         


Pro Leu Leu Cys His Ser Ser Lys Pro Lys Leu Asp Thr Leu Gln Lys 
        275                 280                 285             


Pro Tyr Val His Lys Glu Lys Arg Ala Gln Arg Ile Pro Ile Pro Pro 
    290                 295                 300                 


Pro Lys Lys Thr Arg Ala Gln Leu Leu Asp Asp Ile Phe Ile Arg Leu 
305                 310                 315                 320 


Arg Asp Pro Arg Asn Ile Thr Glu Ala Pro Leu Gly Ala Val Leu His 
                325                 330                 335     


Gln Trp Thr Glu Arg Arg Leu Val Asn His Lys Gln Tyr Leu Glu Ala 
            340                 345                 350         


Lys Arg Leu Leu Lys Glu Phe Gln Ala Arg Tyr Arg Gln Leu Val Ser 
        355                 360                 365             


Gly Ser Leu Arg Thr Val Phe Gly Thr Thr Pro Leu Pro Met Ala Cys 
    370                 375                 380                 


Pro Ala Leu Ser Glu Ser Gln Pro Lys Phe Gly His Phe Leu Glu Phe 
385                 390                 395                 400 


Met Asp Glu Phe Cys Gln Glu Pro Thr Ala Ser Asp Ser Gln Gly 
                405                 410                 415 

<210>  2784
<211>  6421
<212>  DNA
<213>  Homo sapiens

<400>  2784
ccccgggggg ctcgcaggcg cgcatccctc ctgactggga cgtcgcctcc gcagacccct     60

cggaggctga agcgacgccg gaggcaggga gatggccttc tcaggaatct acaagctgga    120

tgatgggaag ccttacctga acaactgctt cccagccaga aatctgcttc gcgtgccgga    180

ggaaggccaa ggacactggt tagtggttca gaaaggtaac ctcaagaaga agcccaaggg    240

tttggttgga gcacaagctg aacgtcggga aagcctgaag gcgacttctt ttgagttcaa    300

ggggaagaaa gagtctcggc gggaaaatca ggtggacctt cctggacata tcctggacca    360

ggcttttctg ctgaagcacc actgtgtgag gaagccatca gatctgtgca ccattaatgt    420

gagtggcctg aagttctcca aggccaagga aaatgacttc aagcattttc attctgtgat    480

ttatatcaat gcctcagaaa acctgctgcc tctagaggca tttcacacgt ttccagccct    540

aaaggaactg gatctcgcat ttaatggcat caaaactatc tacgtgaaat atggagactt    600

taagttatta gaattcttgg acctttcctt caacagcctg actgtggagg ccatctgtga    660

tttggggatt ctgccacacc tccgtgtcct gctcctcaca ggcaatggcc ttacctccct    720

gccgcccaat ttggccgtcg cagaacagga ggcatctgta acatcgctga caagcaagag    780

gtacatcctg aggttcccag cgctggagac actgatgctg gatgacaaca gactctccaa    840

ccccagttgc tttgccagcc tggctgggct caggagactg aagaagttaa gcttggatga    900

aaacaggatt atcaggatcc catacctaca gcaagttcag ctctatgacg agtcagtaga    960

ctggaatgga ggcaggggaa gtccccataa agagccccaa ttcatgctgc agtccaagcc   1020

aaggatgctt gaggactcag atgagcaact ggattatact gtactgccca tgaaaaagga   1080

tgttgaccgg acagaggttg tgttttcatc ttaccctgga ttttcaacct cagagacaac   1140

caagatatgt tcacttcctc ccatattcga gatccttcct gtgaagtcac tgaaggccag   1200

gaaccagacg ctggccccac ccttcccaga gctgagatac cttagcctgg cctacaacaa   1260

gatcgcaaaa gaggatgctg tcctaccagt agctctcttc ccatctctct gcgagttcgt   1320

ctttcataac aaccctctgg tggcccatac acgaggggtc cctccactgc tgaagagctt   1380

cctccaggag cgactgggaa tccacttaat tcgaaggaag atagtaaagc ctaagcatca   1440

tgttttgatg tctcggaagg aatcatggaa ggtgaaaagc gaaatcccaa aggtgccgaa   1500

gcagcctctg gtgctccatc acccgcgcat gacgacaacc aagtctccct caaaggatat   1560

gctagagcca gaggcagagc tggctgaaga tctgcccact accaaaagca cttctgtgga   1620

gtcagagatg cccactgaga acctggaagg ccattccccg tcttgccgga ccttcgtgcc   1680

actgcctccc atctgctcca actccactgt gcatagtgaa gagaccctgt cccacctgag   1740

tgacacaact gtccgcctca gcccagagcg cccatcagat gaggactcca agagcacaga   1800

gtccatcttc ctgacccagg tgagtgaact gccttcctcc gtcatccata aggatgattt   1860

agagttaaag gagaaagacc aaaagaaacc accaacggca cccagagagg tgaaagggac   1920

tcggaggaaa ctcccaactg ccttccttcc cagcaagtac cacggctatg aagaactgct   1980

gacagccaag cctgatccag ccttcattga gccaaaggga atccagaaga atgcacaagc   2040

cctgcaacaa atgctgaagc acccactcct gtgccactcc tccaagccca agctggacac   2100

tcttcagaaa ccctatgttc acaaagagaa acgggcccag agaatcccga ttccaccccc   2160

aaagaagact agagcccaac ttctggatga catcttcatt cgcttgcggg atccccggaa   2220

cattacagag gctccactag gtgctgtcct gcaccagtgg acagaacggc ggctggtgaa   2280

ccacaagcag tacctggagg ccaagaggct gttgaaggag ttccaggcac gttaccggca   2340

gctggtgagt ggctctctgc gcacagtgtt cgggactacc ccgctcccca tggcctgccc   2400

agcgctgagt gagagccagc ccaagttcgg ccacttcctc gagttcatgg atgagttctg   2460

ccaggagccc acagccagtg actcacaagg ctagagctgt gcatgggggc tgtgtgcacc   2520

acccggcctg tgccccagct ctccccgagg gctctgtgcc ctggaccgca cctcaaggtt   2580

gaccagccgg ccacaggcct cagagctcag ctgggcccca cttgctggcc acaaggtggc   2640

atccccttgt caggatctcc cctccttggc ccaggcatga cctggtgcct ggcccagcgg   2700

caataaagag tgggtgcaca gggcaataga ctgggtgcca catgcattct ttcttggaac   2760

ccaggccaca gcagcattgt cacacttccc tctaaaaatg gttttccagt tcagatgcaa   2820

cagggataca tttgttctct gttgtatgag aaactgacac caaggggatc ttaacaaatt   2880

cctgaacaat ggctccaaaa aagggtattt ttaaaaacca gatcttgtga gtacagccct   2940

aatgtgcagg gacagtgtca tcctgtatat tcgttcttta ctcagactct ttcttggttc   3000

cttcattagg agcatgaatg gttgaatgtg aacatgacag taaattggag caaactgtaa   3060

actggacata acttatgcca aaagacgtag ttgtacacca tggaaacccc atccctgctc   3120

ctaatctcta ctgccattct gaatgccaaa gcaagacatc caacatgggg catctcccag   3180

agcacataca gcaccaaaaa tccacacaca gcctaagctt aacccatgtt tttgtctgag   3240

attgttcacc agagacaaga ctctgactat aaacagaaca tccactttca tgagtttcct   3300

ttactgtatt ctcaacttgg gccttgcttc aagcaggcaa acatacattg aagaatgcac   3360

tttggtactg tttaaataac aacacatcag cccacttgat tccatgccat gtccttgctg   3420

acagaaacat ccccaacagg gcatgccctg gtccaagtcc tctgtctttg tcaaaatgct   3480

cttctgatga gttggagagg aggcagccag cagtggcagt ccacaaggat ccaggtacct   3540

tctccaatcc taaagcagac agcaggttga ataaaaccaa tacacaacct attttctagg   3600

caggagggga aaaggccctt aggacaataa tatttgtaca aagagttgag agtaaacaaa   3660

cagtgtatca ggttcaaaaa aaaaaaaact attcgttggc atttaaattt ttttcccttg   3720

catagtatct attctctcac taggactttt aagtgctctg ctggaggctc agcgttggta   3780

ataccatgtt tgatgcaaac ttgaacccaa tgctctcatt ggtggcacag ctttggaggg   3840

tggtggcccc aagaaggggc aatctgcctg ctgctatatt aatctggaac cagggccaac   3900

agctactctt gaactatggt atttgaagag cgagttcatt gcctgtttta ccttaaatga   3960

caggaaagga agatgaacaa accttgcttt gccttggctt caaactagtt cttgatttaa   4020

gacaccagaa agggagagag ggagtctgct tagagtttga ggttgcctct cacaagatga   4080

cagttaaaag ttgccacctt acttaaaagg cattaaggag gcatttactc acaaaggaga   4140

gagagtaaat ttttttctta agaggaaaaa aatactgata atacatagaa caatctgcac   4200

atccagtctt ggcacttttt ccaatttgac tgatctctaa actggtgacc cttgcatata   4260

tcttagtctc ttttctacaa tcttcttcag aaagctacag cagctaacaa tcatgtataa   4320

agatgcattt cctagatcat cttcagaaga aaatctcttc agcactttcc ctagaatctg   4380

tctcctgacc accccgcccc agacctgctt tctcttttga gaattcataa ccaggtatgt   4440

ttagatacca gttcaaaaga ccactctatg ggttgatgag gaaaaggctg cctgaggaca   4500

atttaagacc ataatgagtt tccaattttt aaagaaaatt tggctagctg gcttttaatt   4560

cttaattaaa atcattaaat ttaattaaaa ttattccaat caaaatatat cactttccaa   4620

gattccacat tcatattact tacttatact atggagactt tctctacctg agcatgtatt   4680

caggggctat aggtacattt aactctaact aactgaaaaa aatcaggaag aaaaaactat   4740

taaaataaaa taacctccta aatcatttgg gggtatcccc atcattggtg cgtgtgtctg   4800

cgtgtgtcaa actttaatga ttatttattc agaccctgga aaaccacact ataaaatagg   4860

gcactggatc acaagttcgt ttggttaaaa aaaaaaaaaa aaaaaagtgg gggcgggggg   4920

cagagaagaa gtttaacttg gatgatttcc atgcccattc cagctgtaac attctatgac   4980

tgtgacccag cctttgttct cttttctcac tctcctacta gacatttcaa tgaaaagtta   5040

ggcaggaaaa aggaaaggaa tcccaagttg ctgccagctc tgatgagaga tcaggttggg   5100

ggagagatta ggtggttact gaattgaggt gtgggcctcc cctgaccatg tcagtgatcc   5160

acaacccacc tcacttcttg gggcttaagc taaaagcagc ttctgaagag atgttaatgt   5220

cctgtaatca ctagaggaga aaattcattc tccttccata acattactta gtaaaggaaa   5280

agcggtggtg caatcaaatt cacaaatacc aatggggtct ctaaaatgta gaatgcagct   5340

tgctgggtgc tggtcagttt tctaaatggg accagaaatg gctttcctaa gaccataaat   5400

gaactctcca gccacacata cattcaaatg cattccatta gacattgagc tcctcaagag   5460

caggaactgc tttatctcca cagtccagct cagggttggc tcaagtctga agctcagtaa   5520

atgtctgtca aatagaaaag aaaggatgag ccttcggtca tcagctacat gagtcaggca   5580

cggtggcagc ttcccatttt agtcagtttg ccagtttgta accagacagt aatcaattaa   5640

gagctttaat ctcttaagga catttttcct ttagggaaaa tgaacaaaaa ataaaacatt   5700

tattaccagt gctgcttcca agcaaaaatt taaaaattaa attaaaattt aaaaaataag   5760

tgaagccact taggagtttc cctggcaagc ctcacccaag aagacttaac cttttttaaa   5820

aagaggcaaa tagattaaag gggccagggg ctggatgcat aatcccctga tctgatacca   5880

acccaacagg cccagatgac ttcttccagc agatacaatc aatgggtcaa gaacattttc   5940

tcaaagtttc tttccctctc tatggaaaag agctgacagc ccccttctaa gggcaccaca   6000

tttcctggat ttcccctcag actgaccttc accctccccc ctaacttccc ctttaataat   6060

aaaaaaaccc agaatgcata tatacaagga acagagtaag acatgggtaa tttgtatggt   6120

gaactgggct tcaatgattt gtgaggaatt tgttttgtga aatcctgcac ctcttattct   6180

agctcacaaa cccttcccat cgttctgttt ccttccttgt ccttttctgt tcccccaaat   6240

aatacacatc aacatatcga cttttaacca acttcagaat catggaagga gagagggaga   6300

tttttcagaa agaaaagcat tcaggtttta gttattaagg atgggaagca tcttaaaatt   6360

cagataatac cttagtggtt tttccttcct ccaaagccaa cctgattaaa gatcaaccct   6420

c                                                                   6421


<210>  2785
<211>  800
<212>  PRT
<213>  Homo sapiens

<400>  2785


Met Ala Phe Ser Gly Ile Tyr Lys Leu Asp Asp Gly Lys Pro Tyr Leu 
1               5                   10                  15      


Asn Asn Cys Phe Pro Ala Arg Asn Leu Leu Arg Val Pro Glu Glu Gly 
            20                  25                  30          


Gln Gly His Trp Leu Val Val Gln Lys Gly Asn Leu Lys Lys Lys Pro 
        35                  40                  45              


Lys Gly Leu Val Gly Ala Gln Ala Glu Arg Arg Glu Ser Leu Lys Ala 
    50                  55                  60                  


Thr Ser Phe Glu Phe Lys Gly Lys Lys Glu Ser Arg Arg Glu Asn Gln 
65                  70                  75                  80  


Val Asp Leu Pro Gly His Ile Leu Asp Gln Ala Phe Leu Leu Lys His 
                85                  90                  95      


His Cys Val Arg Lys Pro Ser Asp Leu Cys Thr Ile Asn Val Ser Gly 
            100                 105                 110         


Leu Lys Phe Ser Lys Ala Lys Glu Asn Asp Phe Lys His Phe His Ser 
        115                 120                 125             


Val Ile Tyr Ile Asn Ala Ser Glu Asn Leu Leu Pro Leu Glu Ala Phe 
    130                 135                 140                 


His Thr Phe Pro Ala Leu Lys Glu Leu Asp Leu Ala Phe Asn Gly Ile 
145                 150                 155                 160 


Lys Thr Ile Tyr Val Lys Tyr Gly Asp Phe Lys Leu Leu Glu Phe Leu 
                165                 170                 175     


Asp Leu Ser Phe Asn Ser Leu Thr Val Glu Ala Ile Cys Asp Leu Gly 
            180                 185                 190         


Ile Leu Pro His Leu Arg Val Leu Leu Leu Thr Gly Asn Gly Leu Thr 
        195                 200                 205             


Ser Leu Pro Pro Asn Leu Ala Val Ala Glu Gln Glu Ala Ser Val Thr 
    210                 215                 220                 


Ser Leu Thr Ser Lys Arg Tyr Ile Leu Arg Phe Pro Ala Leu Glu Thr 
225                 230                 235                 240 


Leu Met Leu Asp Asp Asn Arg Leu Ser Asn Pro Ser Cys Phe Ala Ser 
                245                 250                 255     


Leu Ala Gly Leu Arg Arg Leu Lys Lys Leu Ser Leu Asp Glu Asn Arg 
            260                 265                 270         


Ile Ile Arg Ile Pro Tyr Leu Gln Gln Val Gln Leu Tyr Asp Glu Ser 
        275                 280                 285             


Val Asp Trp Asn Gly Gly Arg Gly Ser Pro His Lys Glu Pro Gln Phe 
    290                 295                 300                 


Met Leu Gln Ser Lys Pro Arg Met Leu Glu Asp Ser Asp Glu Gln Leu 
305                 310                 315                 320 


Asp Tyr Thr Val Leu Pro Met Lys Lys Asp Val Asp Arg Thr Glu Val 
                325                 330                 335     


Val Phe Ser Ser Tyr Pro Gly Phe Ser Thr Ser Glu Thr Thr Lys Ile 
            340                 345                 350         


Cys Ser Leu Pro Pro Ile Phe Glu Ile Leu Pro Val Lys Ser Leu Lys 
        355                 360                 365             


Ala Arg Asn Gln Thr Leu Ala Pro Pro Phe Pro Glu Leu Arg Tyr Leu 
    370                 375                 380                 


Ser Leu Ala Tyr Asn Lys Ile Ala Lys Glu Asp Ala Val Leu Pro Val 
385                 390                 395                 400 


Ala Leu Phe Pro Ser Leu Cys Glu Phe Val Phe His Asn Asn Pro Leu 
                405                 410                 415     


Val Ala His Thr Arg Gly Val Pro Pro Leu Leu Lys Ser Phe Leu Gln 
            420                 425                 430         


Glu Arg Leu Gly Ile His Leu Ile Arg Arg Lys Ile Val Lys Pro Lys 
        435                 440                 445             


His His Val Leu Met Ser Arg Lys Glu Ser Trp Lys Val Lys Ser Glu 
    450                 455                 460                 


Ile Pro Lys Val Pro Lys Gln Pro Leu Val Leu His His Pro Arg Met 
465                 470                 475                 480 


Thr Thr Thr Lys Ser Pro Ser Lys Asp Met Leu Glu Pro Glu Ala Glu 
                485                 490                 495     


Leu Ala Glu Asp Leu Pro Thr Thr Lys Ser Thr Ser Val Glu Ser Glu 
            500                 505                 510         


Met Pro Thr Glu Asn Leu Glu Gly His Ser Pro Ser Cys Arg Thr Phe 
        515                 520                 525             


Val Pro Leu Pro Pro Ile Cys Ser Asn Ser Thr Val His Ser Glu Glu 
    530                 535                 540                 


Thr Leu Ser His Leu Ser Asp Thr Thr Val Arg Leu Ser Pro Glu Arg 
545                 550                 555                 560 


Pro Ser Asp Glu Asp Ser Lys Ser Thr Glu Ser Ile Phe Leu Thr Gln 
                565                 570                 575     


Val Ser Glu Leu Pro Ser Ser Val Ile His Lys Asp Asp Leu Glu Leu 
            580                 585                 590         


Lys Glu Lys Asp Gln Lys Lys Pro Pro Thr Ala Pro Arg Glu Val Lys 
        595                 600                 605             


Gly Thr Arg Arg Lys Leu Pro Thr Ala Phe Leu Pro Ser Lys Tyr His 
    610                 615                 620                 


Gly Tyr Glu Glu Leu Leu Thr Ala Lys Pro Asp Pro Ala Phe Ile Glu 
625                 630                 635                 640 


Pro Lys Gly Ile Gln Lys Asn Ala Gln Ala Leu Gln Gln Met Leu Lys 
                645                 650                 655     


His Pro Leu Leu Cys His Ser Ser Lys Pro Lys Leu Asp Thr Leu Gln 
            660                 665                 670         


Lys Pro Tyr Val His Lys Glu Lys Arg Ala Gln Arg Ile Pro Ile Pro 
        675                 680                 685             


Pro Pro Lys Lys Thr Arg Ala Gln Leu Leu Asp Asp Ile Phe Ile Arg 
    690                 695                 700                 


Leu Arg Asp Pro Arg Asn Ile Thr Glu Ala Pro Leu Gly Ala Val Leu 
705                 710                 715                 720 


His Gln Trp Thr Glu Arg Arg Leu Val Asn His Lys Gln Tyr Leu Glu 
                725                 730                 735     


Ala Lys Arg Leu Leu Lys Glu Phe Gln Ala Arg Tyr Arg Gln Leu Val 
            740                 745                 750         


Ser Gly Ser Leu Arg Thr Val Phe Gly Thr Thr Pro Leu Pro Met Ala 
        755                 760                 765             


Cys Pro Ala Leu Ser Glu Ser Gln Pro Lys Phe Gly His Phe Leu Glu 
    770                 775                 780                 


Phe Met Asp Glu Phe Cys Gln Glu Pro Thr Ala Ser Asp Ser Gln Gly 
785                 790                 795                 800 

<210>  2786
<211>  6160
<212>  DNA
<213>  Homo sapiens

<400>  2786
ccccgggggg ctcgcaggcg cgcatccctc ctgactggga cgtcgcctcc gcagacccct     60

cggaggctga agcgacgccg gaggcaggga gatggccttc tcaggaatct acaagctgga    120

tgatgggaag ccttacctga acaactgctt cccagccaga aatctgcttc gcgtgccgga    180

ggaaggccaa ggacactggt tagtggttca gaaaggtaac ctcaagaaga agcccaaggg    240

tttggttgga gcacaagctg aacgtcggga aagcctgaag gcgacttctt ttgagttcaa    300

ggggaagaaa gagtctcggc gggaaaatca ggtggacctt cctggacata tcctggacca    360

ggcttttctg ctgaagcacc actgtgtgag gaagccatca gatctgtgca ccattaatgt    420

gagtggcctg aagttctcca aggccaagga aaatgacttc aagcattttc attctgtgat    480

ttatatcaat gcctcagaaa acctgctgcc tctagaggca tttcacacgt ttccagccct    540

aaaggaactg gatctcgcat ttaatggcat caaaactatc tacgtgaaat atggagactt    600

taagttatta gaattcttgg acctttcctt caacagcctg actgtggagg ccatctgtga    660

tttggggatt ctgccacacc tccgtgtcct gctcctcaca ggcaatggcc ttacctccct    720

gccgcccaat ttggccgtcg cagaacagga ggcatctgta acatcgctga caagcaagag    780

gtacatcctg aggttcccag cgctggagac actgatgctg gatgacaaca gactctccaa    840

ccccagttgc tttgccagcc tggctgggct caggagactg aagaagttaa gcttggatga    900

aaacaggatt atcaggatcc catacctaca gcaagttcag ctctatgacg agtcagtaga    960

ctggaatgga ggcaggggaa gtccccataa agagccccaa ttcatgctgc agtccaagcc   1020

aaggatgctt gaggactcag atgagcaact ggattatact gtactgccca tgaaaaagga   1080

tgttgaccgg acaggggtcc ctccactgct gaagagcttc ctccaggagc gactgggaat   1140

ccacttaatt cgaaggaaga tagtaaagcc taagcatcat gttttgatgt ctcggaagga   1200

atcatggaag gtgaaaagcg aaatcccaaa ggtgccgaag cagcctctgg tgctccatca   1260

cccgcgcatg acgacaacca agtctccctc aaaggatatg ctagagccag aggcagagct   1320

ggctgaagat ctgcccacta ccaaaagcac ttctgtggag tcagagatgc ccactgagaa   1380

cctggaaggc cattccccgt cttgccggac cttcgtgcca ctgcctccca tctgctccaa   1440

ctccactgtg catagtgaag agaccctgtc ccacctgagt gacacaactg tccgcctcag   1500

cccagagcgc ccatcagatg aggactccaa gagcacagag tccatcttcc tgacccaggt   1560

gagtgaactg ccttcctccg tcatccataa ggatgattta gagttaaagg agaaagacca   1620

aaagaaacca ccaacggcac ccagagaggt gaaagggact cggaggaaac tcccaactgc   1680

cttccttccc agcaagtacc acggctatga agaactgctg acagccaagc ctgatccagc   1740

cttcattgag ccaaagggaa tccagaagaa tgcacaagcc ctgcaacaaa tgctgaagca   1800

cccactcctg tgccactcct ccaagcccaa gctggacact cttcagaaac cctatgttca   1860

caaagagaaa cgggcccaga gaatcccgat tccaccccca aagaagacta gagcccaact   1920

tctggatgac atcttcattc gcttgcggga tccccggaac attacagagg ctccactagg   1980

tgctgtcctg caccagtgga cagaacggcg gctggtgaac cacaagcagt acctggaggc   2040

caagaggctg ttgaaggagt tccaggcacg ttaccggcag ctggtgagtg gctctctgcg   2100

cacagtgttc gggactaccc cgctccccat ggcctgccca gcgctgagtg agagccagcc   2160

caagttcggc cacttcctcg agttcatgga tgagttctgc caggagccca cagccagtga   2220

ctcacaaggc tagagctgtg catgggggct gtgtgcacca cccggcctgt gccccagctc   2280

tccccgaggg ctctgtgccc tggaccgcac ctcaaggttg accagccggc cacaggcctc   2340

agagctcagc tgggccccac ttgctggcca caaggtggca tccccttgtc aggatctccc   2400

ctccttggcc caggcatgac ctggtgcctg gcccagcggc aataaagagt gggtgcacag   2460

ggcaatagac tgggtgccac atgcattctt tcttggaacc caggccacag cagcattgtc   2520

acacttccct ctaaaaatgg ttttccagtt cagatgcaac agggatacat ttgttctctg   2580

ttgtatgaga aactgacacc aaggggatct taacaaattc ctgaacaatg gctccaaaaa   2640

agggtatttt taaaaaccag atcttgtgag tacagcccta atgtgcaggg acagtgtcat   2700

cctgtatatt cgttctttac tcagactctt tcttggttcc ttcattagga gcatgaatgg   2760

ttgaatgtga acatgacagt aaattggagc aaactgtaaa ctggacataa cttatgccaa   2820

aagacgtagt tgtacaccat ggaaacccca tccctgctcc taatctctac tgccattctg   2880

aatgccaaag caagacatcc aacatggggc atctcccaga gcacatacag caccaaaaat   2940

ccacacacag cctaagctta acccatgttt ttgtctgaga ttgttcacca gagacaagac   3000

tctgactata aacagaacat ccactttcat gagtttcctt tactgtattc tcaacttggg   3060

ccttgcttca agcaggcaaa catacattga agaatgcact ttggtactgt ttaaataaca   3120

acacatcagc ccacttgatt ccatgccatg tccttgctga cagaaacatc cccaacaggg   3180

catgccctgg tccaagtcct ctgtctttgt caaaatgctc ttctgatgag ttggagagga   3240

ggcagccagc agtggcagtc cacaaggatc caggtacctt ctccaatcct aaagcagaca   3300

gcaggttgaa taaaaccaat acacaaccta ttttctaggc aggaggggaa aaggccctta   3360

ggacaataat atttgtacaa agagttgaga gtaaacaaac agtgtatcag gttcaaaaaa   3420

aaaaaaacta ttcgttggca tttaaatttt tttcccttgc atagtatcta ttctctcact   3480

aggactttta agtgctctgc tggaggctca gcgttggtaa taccatgttt gatgcaaact   3540

tgaacccaat gctctcattg gtggcacagc tttggagggt ggtggcccca agaaggggca   3600

atctgcctgc tgctatatta atctggaacc agggccaaca gctactcttg aactatggta   3660

tttgaagagc gagttcattg cctgttttac cttaaatgac aggaaaggaa gatgaacaaa   3720

ccttgctttg ccttggcttc aaactagttc ttgatttaag acaccagaaa gggagagagg   3780

gagtctgctt agagtttgag gttgcctctc acaagatgac agttaaaagt tgccacctta   3840

cttaaaaggc attaaggagg catttactca caaaggagag agagtaaatt tttttcttaa   3900

gaggaaaaaa atactgataa tacatagaac aatctgcaca tccagtcttg gcactttttc   3960

caatttgact gatctctaaa ctggtgaccc ttgcatatat cttagtctct tttctacaat   4020

cttcttcaga aagctacagc agctaacaat catgtataaa gatgcatttc ctagatcatc   4080

ttcagaagaa aatctcttca gcactttccc tagaatctgt ctcctgacca ccccgcccca   4140

gacctgcttt ctcttttgag aattcataac caggtatgtt tagataccag ttcaaaagac   4200

cactctatgg gttgatgagg aaaaggctgc ctgaggacaa tttaagacca taatgagttt   4260

ccaattttta aagaaaattt ggctagctgg cttttaattc ttaattaaaa tcattaaatt   4320

taattaaaat tattccaatc aaaatatatc actttccaag attccacatt catattactt   4380

acttatacta tggagacttt ctctacctga gcatgtattc aggggctata ggtacattta   4440

actctaacta actgaaaaaa atcaggaaga aaaaactatt aaaataaaat aacctcctaa   4500

atcatttggg ggtatcccca tcattggtgc gtgtgtctgc gtgtgtcaaa ctttaatgat   4560

tatttattca gaccctggaa aaccacacta taaaataggg cactggatca caagttcgtt   4620

tggttaaaaa aaaaaaaaaa aaaaagtggg ggcggggggc agagaagaag tttaacttgg   4680

atgatttcca tgcccattcc agctgtaaca ttctatgact gtgacccagc ctttgttctc   4740

ttttctcact ctcctactag acatttcaat gaaaagttag gcaggaaaaa ggaaaggaat   4800

cccaagttgc tgccagctct gatgagagat caggttgggg gagagattag gtggttactg   4860

aattgaggtg tgggcctccc ctgaccatgt cagtgatcca caacccacct cacttcttgg   4920

ggcttaagct aaaagcagct tctgaagaga tgttaatgtc ctgtaatcac tagaggagaa   4980

aattcattct ccttccataa cattacttag taaaggaaaa gcggtggtgc aatcaaattc   5040

acaaatacca atggggtctc taaaatgtag aatgcagctt gctgggtgct ggtcagtttt   5100

ctaaatggga ccagaaatgg ctttcctaag accataaatg aactctccag ccacacatac   5160

attcaaatgc attccattag acattgagct cctcaagagc aggaactgct ttatctccac   5220

agtccagctc agggttggct caagtctgaa gctcagtaaa tgtctgtcaa atagaaaaga   5280

aaggatgagc cttcggtcat cagctacatg agtcaggcac ggtggcagct tcccatttta   5340

gtcagtttgc cagtttgtaa ccagacagta atcaattaag agctttaatc tcttaaggac   5400

atttttcctt tagggaaaat gaacaaaaaa taaaacattt attaccagtg ctgcttccaa   5460

gcaaaaattt aaaaattaaa ttaaaattta aaaaataagt gaagccactt aggagtttcc   5520

ctggcaagcc tcacccaaga agacttaacc ttttttaaaa agaggcaaat agattaaagg   5580

ggccaggggc tggatgcata atcccctgat ctgataccaa cccaacaggc ccagatgact   5640

tcttccagca gatacaatca atgggtcaag aacattttct caaagtttct ttccctctct   5700

atggaaaaga gctgacagcc cccttctaag ggcaccacat ttcctggatt tcccctcaga   5760

ctgaccttca ccctcccccc taacttcccc tttaataata aaaaaaccca gaatgcatat   5820

atacaaggaa cagagtaaga catgggtaat ttgtatggtg aactgggctt caatgatttg   5880

tgaggaattt gttttgtgaa atcctgcacc tcttattcta gctcacaaac ccttcccatc   5940

gttctgtttc cttccttgtc cttttctgtt cccccaaata atacacatca acatatcgac   6000

ttttaaccaa cttcagaatc atggaaggag agagggagat ttttcagaaa gaaaagcatt   6060

caggttttag ttattaagga tgggaagcat cttaaaattc agataatacc ttagtggttt   6120

ttccttcctc caaagccaac ctgattaaag atcaaccctc                         6160


<210>  2787
<211>  713
<212>  PRT
<213>  Homo sapiens

<400>  2787


Met Ala Phe Ser Gly Ile Tyr Lys Leu Asp Asp Gly Lys Pro Tyr Leu 
1               5                   10                  15      


Asn Asn Cys Phe Pro Ala Arg Asn Leu Leu Arg Val Pro Glu Glu Gly 
            20                  25                  30          


Gln Gly His Trp Leu Val Val Gln Lys Gly Asn Leu Lys Lys Lys Pro 
        35                  40                  45              


Lys Gly Leu Val Gly Ala Gln Ala Glu Arg Arg Glu Ser Leu Lys Ala 
    50                  55                  60                  


Thr Ser Phe Glu Phe Lys Gly Lys Lys Glu Ser Arg Arg Glu Asn Gln 
65                  70                  75                  80  


Val Asp Leu Pro Gly His Ile Leu Asp Gln Ala Phe Leu Leu Lys His 
                85                  90                  95      


His Cys Val Arg Lys Pro Ser Asp Leu Cys Thr Ile Asn Val Ser Gly 
            100                 105                 110         


Leu Lys Phe Ser Lys Ala Lys Glu Asn Asp Phe Lys His Phe His Ser 
        115                 120                 125             


Val Ile Tyr Ile Asn Ala Ser Glu Asn Leu Leu Pro Leu Glu Ala Phe 
    130                 135                 140                 


His Thr Phe Pro Ala Leu Lys Glu Leu Asp Leu Ala Phe Asn Gly Ile 
145                 150                 155                 160 


Lys Thr Ile Tyr Val Lys Tyr Gly Asp Phe Lys Leu Leu Glu Phe Leu 
                165                 170                 175     


Asp Leu Ser Phe Asn Ser Leu Thr Val Glu Ala Ile Cys Asp Leu Gly 
            180                 185                 190         


Ile Leu Pro His Leu Arg Val Leu Leu Leu Thr Gly Asn Gly Leu Thr 
        195                 200                 205             


Ser Leu Pro Pro Asn Leu Ala Val Ala Glu Gln Glu Ala Ser Val Thr 
    210                 215                 220                 


Ser Leu Thr Ser Lys Arg Tyr Ile Leu Arg Phe Pro Ala Leu Glu Thr 
225                 230                 235                 240 


Leu Met Leu Asp Asp Asn Arg Leu Ser Asn Pro Ser Cys Phe Ala Ser 
                245                 250                 255     


Leu Ala Gly Leu Arg Arg Leu Lys Lys Leu Ser Leu Asp Glu Asn Arg 
            260                 265                 270         


Ile Ile Arg Ile Pro Tyr Leu Gln Gln Val Gln Leu Tyr Asp Glu Ser 
        275                 280                 285             


Val Asp Trp Asn Gly Gly Arg Gly Ser Pro His Lys Glu Pro Gln Phe 
    290                 295                 300                 


Met Leu Gln Ser Lys Pro Arg Met Leu Glu Asp Ser Asp Glu Gln Leu 
305                 310                 315                 320 


Asp Tyr Thr Val Leu Pro Met Lys Lys Asp Val Asp Arg Thr Gly Val 
                325                 330                 335     


Pro Pro Leu Leu Lys Ser Phe Leu Gln Glu Arg Leu Gly Ile His Leu 
            340                 345                 350         


Ile Arg Arg Lys Ile Val Lys Pro Lys His His Val Leu Met Ser Arg 
        355                 360                 365             


Lys Glu Ser Trp Lys Val Lys Ser Glu Ile Pro Lys Val Pro Lys Gln 
    370                 375                 380                 


Pro Leu Val Leu His His Pro Arg Met Thr Thr Thr Lys Ser Pro Ser 
385                 390                 395                 400 


Lys Asp Met Leu Glu Pro Glu Ala Glu Leu Ala Glu Asp Leu Pro Thr 
                405                 410                 415     


Thr Lys Ser Thr Ser Val Glu Ser Glu Met Pro Thr Glu Asn Leu Glu 
            420                 425                 430         


Gly His Ser Pro Ser Cys Arg Thr Phe Val Pro Leu Pro Pro Ile Cys 
        435                 440                 445             


Ser Asn Ser Thr Val His Ser Glu Glu Thr Leu Ser His Leu Ser Asp 
    450                 455                 460                 


Thr Thr Val Arg Leu Ser Pro Glu Arg Pro Ser Asp Glu Asp Ser Lys 
465                 470                 475                 480 


Ser Thr Glu Ser Ile Phe Leu Thr Gln Val Ser Glu Leu Pro Ser Ser 
                485                 490                 495     


Val Ile His Lys Asp Asp Leu Glu Leu Lys Glu Lys Asp Gln Lys Lys 
            500                 505                 510         


Pro Pro Thr Ala Pro Arg Glu Val Lys Gly Thr Arg Arg Lys Leu Pro 
        515                 520                 525             


Thr Ala Phe Leu Pro Ser Lys Tyr His Gly Tyr Glu Glu Leu Leu Thr 
    530                 535                 540                 


Ala Lys Pro Asp Pro Ala Phe Ile Glu Pro Lys Gly Ile Gln Lys Asn 
545                 550                 555                 560 


Ala Gln Ala Leu Gln Gln Met Leu Lys His Pro Leu Leu Cys His Ser 
                565                 570                 575     


Ser Lys Pro Lys Leu Asp Thr Leu Gln Lys Pro Tyr Val His Lys Glu 
            580                 585                 590         


Lys Arg Ala Gln Arg Ile Pro Ile Pro Pro Pro Lys Lys Thr Arg Ala 
        595                 600                 605             


Gln Leu Leu Asp Asp Ile Phe Ile Arg Leu Arg Asp Pro Arg Asn Ile 
    610                 615                 620                 


Thr Glu Ala Pro Leu Gly Ala Val Leu His Gln Trp Thr Glu Arg Arg 
625                 630                 635                 640 


Leu Val Asn His Lys Gln Tyr Leu Glu Ala Lys Arg Leu Leu Lys Glu 
                645                 650                 655     


Phe Gln Ala Arg Tyr Arg Gln Leu Val Ser Gly Ser Leu Arg Thr Val 
            660                 665                 670         


Phe Gly Thr Thr Pro Leu Pro Met Ala Cys Pro Ala Leu Ser Glu Ser 
        675                 680                 685             


Gln Pro Lys Phe Gly His Phe Leu Glu Phe Met Asp Glu Phe Cys Gln 
    690                 695                 700                 


Glu Pro Thr Ala Ser Asp Ser Gln Gly 
705                 710             

<210>  2788
<211>  6068
<212>  DNA
<213>  Homo sapiens

<400>  2788
tgccgcctac actgtctgcc gtcgcgtcgc agttactaag gcgtggggaa gatagcggca     60

ggcaccgcag tggagcggct ccgagatccc cggggggctc gcaggcgcgc atccctcctg    120

actgggacgt cgcctccgca gacccctcgg aggctgaagc gacgccggag gcaggcaaag    180

aaacaagtga agaaacaaaa aaaaaaggaa gttaaggggc cattcccaaa gtcaaagatc    240

aagccaagga cactggttag tggttcagaa aggtaacctc aagaagaagc ccaagggttt    300

ggttggagca caagctgaac gtcgggaaag cctgaaggcg acttcttttg agttcaaggg    360

gaagaaagag tctcggcggg aaaatcaggt ggaccttcct ggacatatcc tggaccaggc    420

ttttctgttc ttggaccttt ccttcaacag cctgactgtg gaggccatct gtgatttggg    480

gattctgcca cacctccgtg tcctgctcct cacaggcaat ggccttacct ccctgccgcc    540

caatttggcc gtcgcagaac aggaggcatc tgtaacatcg ctgacaagca agaggtacat    600

cctgaggttc ccagcgctgg agacactgat gctggatgac aacagactct ccaaccccag    660

ttgctttgcc agcctggctg ggctcaggag actgaagaag ttaagcttgg atgaaaacag    720

gattatcagg atcccatacc tacagcaagt tcagctctat gacgagtcag tagactggaa    780

tggaggcagg ggaagtcccc ataaagagcc ccaattcatg ctgcagtcca agccaaggat    840

gcttgaggac tcagatgagc aactggatta tactgtactg cccatgaaaa aggatgttga    900

ccggacagat cgcaaaagag gatgctgtcc taccagtagc tctcttccca tctctctgcg    960

agttcgtctt tcataacaac cctctggtgg cccatacacg aggggtccct ccactgctga   1020

agagcttcct ccaggagcga ctgggaatcc acttaattcg aaggaagata gtaaagccta   1080

agcatcatgt tttgatgtct cggaaggaat catggaaggt gaaaagcgaa atcccaaagg   1140

tgccgaagca gcctctggtg ctccatcacc cgcgcatgac gacaaccaag tctccctcaa   1200

aggatatgct agagccagag gcagagctgg ctgaagatct gcccactacc aaaagcactt   1260

ctgtggagtc agagatgccc actgagaacc tggaaggcca ttccccgtct tgccggacct   1320

tcgtgccact gcctcccatc tgctccaact ccactgtgca tagtgaagag accctgtccc   1380

acctgagtga cacaactgtc cgcctcagcc cagagcgccc atcagatgag gactccaaga   1440

gcacagagtc catcttcctg acccaggtga gtgaactgcc ttcctccgtc atccataagg   1500

atgatttaga gttaaaggag aaagaccaaa agaaaccacc aacggcaccc agagaggtga   1560

aagggactcg gaggaaactc ccaactgcct tccttcccag caagtaccac ggctatgaag   1620

aactgctgac agccaagcct gatccagcct tcattgagcc aaagggaatc cagaagaatg   1680

cacaagccct gcaacaaatg ctgaagcacc cactcctgtg ccactcctcc aagcccaagc   1740

tggacactct tcagaaaccc tatgttcaca aagagaaacg ggcccagaga atcccgattc   1800

cacccccaaa gaagactaga gcccaacttc tggatgacat cttcattcgc ttgcgggatc   1860

cccggaacat tacagaggct ccactaggtg ctgtcctgca ccagtggaca gaacggcggc   1920

tggtgaacca caagcagtac ctggaggcca agaggctgtt gaaggagttc caggcacgtt   1980

accggcagct ggtgagtggc tctctgcgca cagtgttcgg gactaccccg ctccccatgg   2040

cctgcccagc gctgagtgag agccagccca agttcggcca cttcctcgag ttcatggatg   2100

agttctgcca ggagcccaca gccagtgact cacaaggcta gagctgtgca tgggggctgt   2160

gtgcaccacc cggcctgtgc cccagctctc cccgagggct ctgtgccctg gaccgcacct   2220

caaggttgac cagccggcca caggcctcag agctcagctg ggccccactt gctggccaca   2280

aggtggcatc cccttgtcag gatctcccct ccttggccca ggcatgacct ggtgcctggc   2340

ccagcggcaa taaagagtgg gtgcacaggg caatagactg ggtgccacat gcattctttc   2400

ttggaaccca ggccacagca gcattgtcac acttccctct aaaaatggtt ttccagttca   2460

gatgcaacag ggatacattt gttctctgtt gtatgagaaa ctgacaccaa ggggatctta   2520

acaaattcct gaacaatggc tccaaaaaag ggtattttta aaaaccagat cttgtgagta   2580

cagccctaat gtgcagggac agtgtcatcc tgtatattcg ttctttactc agactctttc   2640

ttggttcctt cattaggagc atgaatggtt gaatgtgaac atgacagtaa attggagcaa   2700

actgtaaact ggacataact tatgccaaaa gacgtagttg tacaccatgg aaaccccatc   2760

cctgctccta atctctactg ccattctgaa tgccaaagca agacatccaa catggggcat   2820

ctcccagagc acatacagca ccaaaaatcc acacacagcc taagcttaac ccatgttttt   2880

gtctgagatt gttcaccaga gacaagactc tgactataaa cagaacatcc actttcatga   2940

gtttccttta ctgtattctc aacttgggcc ttgcttcaag caggcaaaca tacattgaag   3000

aatgcacttt ggtactgttt aaataacaac acatcagccc acttgattcc atgccatgtc   3060

cttgctgaca gaaacatccc caacagggca tgccctggtc caagtcctct gtctttgtca   3120

aaatgctctt ctgatgagtt ggagaggagg cagccagcag tggcagtcca caaggatcca   3180

ggtaccttct ccaatcctaa agcagacagc aggttgaata aaaccaatac acaacctatt   3240

ttctaggcag gaggggaaaa ggcccttagg acaataatat ttgtacaaag agttgagagt   3300

aaacaaacag tgtatcaggt tcaaaaaaaa aaaaactatt cgttggcatt taaatttttt   3360

tcccttgcat agtatctatt ctctcactag gacttttaag tgctctgctg gaggctcagc   3420

gttggtaata ccatgtttga tgcaaacttg aacccaatgc tctcattggt ggcacagctt   3480

tggagggtgg tggccccaag aaggggcaat ctgcctgctg ctatattaat ctggaaccag   3540

ggccaacagc tactcttgaa ctatggtatt tgaagagcga gttcattgcc tgttttacct   3600

taaatgacag gaaaggaaga tgaacaaacc ttgctttgcc ttggcttcaa actagttctt   3660

gatttaagac accagaaagg gagagaggga gtctgcttag agtttgaggt tgcctctcac   3720

aagatgacag ttaaaagttg ccaccttact taaaaggcat taaggaggca tttactcaca   3780

aaggagagag agtaaatttt tttcttaaga ggaaaaaaat actgataata catagaacaa   3840

tctgcacatc cagtcttggc actttttcca atttgactga tctctaaact ggtgaccctt   3900

gcatatatct tagtctcttt tctacaatct tcttcagaaa gctacagcag ctaacaatca   3960

tgtataaaga tgcatttcct agatcatctt cagaagaaaa tctcttcagc actttcccta   4020

gaatctgtct cctgaccacc ccgccccaga cctgctttct cttttgagaa ttcataacca   4080

ggtatgttta gataccagtt caaaagacca ctctatgggt tgatgaggaa aaggctgcct   4140

gaggacaatt taagaccata atgagtttcc aatttttaaa gaaaatttgg ctagctggct   4200

tttaattctt aattaaaatc attaaattta attaaaatta ttccaatcaa aatatatcac   4260

tttccaagat tccacattca tattacttac ttatactatg gagactttct ctacctgagc   4320

atgtattcag gggctatagg tacatttaac tctaactaac tgaaaaaaat caggaagaaa   4380

aaactattaa aataaaataa cctcctaaat catttggggg tatccccatc attggtgcgt   4440

gtgtctgcgt gtgtcaaact ttaatgatta tttattcaga ccctggaaaa ccacactata   4500

aaatagggca ctggatcaca agttcgtttg gttaaaaaaa aaaaaaaaaa aaagtggggg   4560

cggggggcag agaagaagtt taacttggat gatttccatg cccattccag ctgtaacatt   4620

ctatgactgt gacccagcct ttgttctctt ttctcactct cctactagac atttcaatga   4680

aaagttaggc aggaaaaagg aaaggaatcc caagttgctg ccagctctga tgagagatca   4740

ggttggggga gagattaggt ggttactgaa ttgaggtgtg ggcctcccct gaccatgtca   4800

gtgatccaca acccacctca cttcttgggg cttaagctaa aagcagcttc tgaagagatg   4860

ttaatgtcct gtaatcacta gaggagaaaa ttcattctcc ttccataaca ttacttagta   4920

aaggaaaagc ggtggtgcaa tcaaattcac aaataccaat ggggtctcta aaatgtagaa   4980

tgcagcttgc tgggtgctgg tcagttttct aaatgggacc agaaatggct ttcctaagac   5040

cataaatgaa ctctccagcc acacatacat tcaaatgcat tccattagac attgagctcc   5100

tcaagagcag gaactgcttt atctccacag tccagctcag ggttggctca agtctgaagc   5160

tcagtaaatg tctgtcaaat agaaaagaaa ggatgagcct tcggtcatca gctacatgag   5220

tcaggcacgg tggcagcttc ccattttagt cagtttgcca gtttgtaacc agacagtaat   5280

caattaagag ctttaatctc ttaaggacat ttttccttta gggaaaatga acaaaaaata   5340

aaacatttat taccagtgct gcttccaagc aaaaatttaa aaattaaatt aaaatttaaa   5400

aaataagtga agccacttag gagtttccct ggcaagcctc acccaagaag acttaacctt   5460

ttttaaaaag aggcaaatag attaaagggg ccaggggctg gatgcataat cccctgatct   5520

gataccaacc caacaggccc agatgacttc ttccagcaga tacaatcaat gggtcaagaa   5580

cattttctca aagtttcttt ccctctctat ggaaaagagc tgacagcccc cttctaaggg   5640

caccacattt cctggatttc ccctcagact gaccttcacc ctccccccta acttcccctt   5700

taataataaa aaaacccaga atgcatatat acaaggaaca gagtaagaca tgggtaattt   5760

gtatggtgaa ctgggcttca atgatttgtg aggaatttgt tttgtgaaat cctgcacctc   5820

ttattctagc tcacaaaccc ttcccatcgt tctgtttcct tccttgtcct tttctgttcc   5880

cccaaataat acacatcaac atatcgactt ttaaccaact tcagaatcat ggaaggagag   5940

agggagattt ttcagaaaga aaagcattca ggttttagtt attaaggatg ggaagcatct   6000

taaaattcag ataatacctt agtggttttt ccttcctcca aagccaacct gattaaagat   6060

caaccctc                                                            6068


<210>  2789
<211>  415
<212>  PRT
<213>  Homo sapiens

<400>  2789


Met Leu Thr Gly Gln Ile Ala Lys Glu Asp Ala Val Leu Pro Val Ala 
1               5                   10                  15      


Leu Phe Pro Ser Leu Cys Glu Phe Val Phe His Asn Asn Pro Leu Val 
            20                  25                  30          


Ala His Thr Arg Gly Val Pro Pro Leu Leu Lys Ser Phe Leu Gln Glu 
        35                  40                  45              


Arg Leu Gly Ile His Leu Ile Arg Arg Lys Ile Val Lys Pro Lys His 
    50                  55                  60                  


His Val Leu Met Ser Arg Lys Glu Ser Trp Lys Val Lys Ser Glu Ile 
65                  70                  75                  80  


Pro Lys Val Pro Lys Gln Pro Leu Val Leu His His Pro Arg Met Thr 
                85                  90                  95      


Thr Thr Lys Ser Pro Ser Lys Asp Met Leu Glu Pro Glu Ala Glu Leu 
            100                 105                 110         


Ala Glu Asp Leu Pro Thr Thr Lys Ser Thr Ser Val Glu Ser Glu Met 
        115                 120                 125             


Pro Thr Glu Asn Leu Glu Gly His Ser Pro Ser Cys Arg Thr Phe Val 
    130                 135                 140                 


Pro Leu Pro Pro Ile Cys Ser Asn Ser Thr Val His Ser Glu Glu Thr 
145                 150                 155                 160 


Leu Ser His Leu Ser Asp Thr Thr Val Arg Leu Ser Pro Glu Arg Pro 
                165                 170                 175     


Ser Asp Glu Asp Ser Lys Ser Thr Glu Ser Ile Phe Leu Thr Gln Val 
            180                 185                 190         


Ser Glu Leu Pro Ser Ser Val Ile His Lys Asp Asp Leu Glu Leu Lys 
        195                 200                 205             


Glu Lys Asp Gln Lys Lys Pro Pro Thr Ala Pro Arg Glu Val Lys Gly 
    210                 215                 220                 


Thr Arg Arg Lys Leu Pro Thr Ala Phe Leu Pro Ser Lys Tyr His Gly 
225                 230                 235                 240 


Tyr Glu Glu Leu Leu Thr Ala Lys Pro Asp Pro Ala Phe Ile Glu Pro 
                245                 250                 255     


Lys Gly Ile Gln Lys Asn Ala Gln Ala Leu Gln Gln Met Leu Lys His 
            260                 265                 270         


Pro Leu Leu Cys His Ser Ser Lys Pro Lys Leu Asp Thr Leu Gln Lys 
        275                 280                 285             


Pro Tyr Val His Lys Glu Lys Arg Ala Gln Arg Ile Pro Ile Pro Pro 
    290                 295                 300                 


Pro Lys Lys Thr Arg Ala Gln Leu Leu Asp Asp Ile Phe Ile Arg Leu 
305                 310                 315                 320 


Arg Asp Pro Arg Asn Ile Thr Glu Ala Pro Leu Gly Ala Val Leu His 
                325                 330                 335     


Gln Trp Thr Glu Arg Arg Leu Val Asn His Lys Gln Tyr Leu Glu Ala 
            340                 345                 350         


Lys Arg Leu Leu Lys Glu Phe Gln Ala Arg Tyr Arg Gln Leu Val Ser 
        355                 360                 365             


Gly Ser Leu Arg Thr Val Phe Gly Thr Thr Pro Leu Pro Met Ala Cys 
    370                 375                 380                 


Pro Ala Leu Ser Glu Ser Gln Pro Lys Phe Gly His Phe Leu Glu Phe 
385                 390                 395                 400 


Met Asp Glu Phe Cys Gln Glu Pro Thr Ala Ser Asp Ser Gln Gly 
                405                 410                 415 

<210>  2790
<211>  6275
<212>  DNA
<213>  Homo sapiens

<400>  2790
gggacttgag gttagacgtc ccggccgtcg gttgccgcct acactgtctg ccgtcgcgtc     60

gcagttacta aggcgtgggg aagatagcgg caggcaccgc agtggagcgg ctccgagatc    120

cccggggggc tcgcaggcgc gcatccctcc tgactgggac gtcgcctccg cagacccctc    180

ggaggctgaa gcgacgccgg aggcaggcca aggacactgg ttagtggttc agaaaggtaa    240

cctcaagaag aagcccaagg gtttggttgg agcacaagct gaacgtcggg aaagcctgaa    300

ggcgacttct tttgagttca aggggaagaa agagtctcgg cgggaaaatc aggtggacct    360

tcctggacat atcctggacc aggcttttct gctgaagcac cactgtgtga ggaagccatc    420

agatctgtgc accattaatg tgagtggcct gaagttctcc aaggccaagg aaaatgactt    480

caagcatttt cattctgtga tttatatcaa tgcctcagaa aacctgctgc ctctagaggc    540

atttcacacg tttccagccc taaaggaact ggatctcgca tttaatggca tcaaaactat    600

ctacgtgaaa tatggagact ttaagttatt agaattcttg gacctttcct tcaacagcct    660

gactgtggag gccatctgtg atttggggat tctgccacac ctccgtgtcc tgctcctcac    720

aggcaatggc cttacctccc tgccgcccaa tttggccgtc gcagaacagg aggcatctgt    780

aacatcgctg acaagcaaga ggtacatcct gaggttccca gcgctggaga cactgatgct    840

ggatgacaac agactctcca accccagttg ctttgccagc ctggctgggc tcaggagact    900

gaagaagtta agcttggatg aaaacaggat tatcaggatc ccatacctac agcaagttca    960

gctctatgac gagtcagtag actggaatgg aggcagggga agtccccata aagagcccca   1020

attcatgctg cagtccaagc caaggatgct tgaggactca gatgagcaac tggattatac   1080

tgtactgccc atgaaaaagg atgttgaccg gacagatcgc aaaagaggat gctgtcctac   1140

cagtagctct cttcccatct ctctgcgagt tcgtctttca taacaaccct ctggtggccc   1200

atacacgagg ggtccctcca ctgctgaaga gcttcctcca ggagcgactg ggaatccact   1260

taattcgaag gaagatagta aagcctaagc atcatgtttt gatgtctcgg aaggaatcat   1320

ggaaggtgaa aagcgaaatc ccaaaggtgc cgaagcagcc tctggtgctc catcacccgc   1380

gcatgacgac aaccaagtct ccctcaaagg atatgctaga gccagaggca gagctggctg   1440

aagatctgcc cactaccaaa agcacttctg tggagtcaga gatgcccact gagaacctgg   1500

aaggccattc cccgtcttgc cggaccttcg tgccactgcc tcccatctgc tccaactcca   1560

ctgtgcatag tgaagagacc ctgtcccacc tgagtgacac aactgtccgc ctcagcccag   1620

agcgcccatc agatgaggac tccaagagca cagagtccat cttcctgacc caggtgagtg   1680

aactgccttc ctccgtcatc cataaggatg atttagagtt aaaggagaaa gaccaaaaga   1740

aaccaccaac ggcacccaga gaggtgaaag ggactcggag gaaactccca actgccttcc   1800

ttcccagcaa gtaccacggc tatgaagaac tgctgacagc caagcctgat ccagccttca   1860

ttgagccaaa gggaatccag aagaatgcac aagccctgca acaaatgctg aagcacccac   1920

tcctgtgcca ctcctccaag cccaagctgg acactcttca gaaaccctat gttcacaaag   1980

agaaacgggc ccagagaatc ccgattccac ccccaaagaa gactagagcc caacttctgg   2040

atgacatctt cattcgcttg cgggatcccc ggaacattac agaggctcca ctaggtgctg   2100

tcctgcacca gtggacagaa cggcggctgg tgaaccacaa gcagtacctg gaggccaaga   2160

ggctgttgaa ggagttccag gcacgttacc ggcagctggt gagtggctct ctgcgcacag   2220

tgttcgggac taccccgctc cccatggcct gcccagcgct gagtgagagc cagcccaagt   2280

tcggccactt cctcgagttc atggatgagt tctgccagga gcccacagcc agtgactcac   2340

aaggctagag ctgtgcatgg gggctgtgtg caccacccgg cctgtgcccc agctctcccc   2400

gagggctctg tgccctggac cgcacctcaa ggttgaccag ccggccacag gcctcagagc   2460

tcagctgggc cccacttgct ggccacaagg tggcatcccc ttgtcaggat ctcccctcct   2520

tggcccaggc atgacctggt gcctggccca gcggcaataa agagtgggtg cacagggcaa   2580

tagactgggt gccacatgca ttctttcttg gaacccaggc cacagcagca ttgtcacact   2640

tccctctaaa aatggttttc cagttcagat gcaacaggga tacatttgtt ctctgttgta   2700

tgagaaactg acaccaaggg gatcttaaca aattcctgaa caatggctcc aaaaaagggt   2760

atttttaaaa accagatctt gtgagtacag ccctaatgtg cagggacagt gtcatcctgt   2820

atattcgttc tttactcaga ctctttcttg gttccttcat taggagcatg aatggttgaa   2880

tgtgaacatg acagtaaatt ggagcaaact gtaaactgga cataacttat gccaaaagac   2940

gtagttgtac accatggaaa ccccatccct gctcctaatc tctactgcca ttctgaatgc   3000

caaagcaaga catccaacat ggggcatctc ccagagcaca tacagcacca aaaatccaca   3060

cacagcctaa gcttaaccca tgtttttgtc tgagattgtt caccagagac aagactctga   3120

ctataaacag aacatccact ttcatgagtt tcctttactg tattctcaac ttgggccttg   3180

cttcaagcag gcaaacatac attgaagaat gcactttggt actgtttaaa taacaacaca   3240

tcagcccact tgattccatg ccatgtcctt gctgacagaa acatccccaa cagggcatgc   3300

cctggtccaa gtcctctgtc tttgtcaaaa tgctcttctg atgagttgga gaggaggcag   3360

ccagcagtgg cagtccacaa ggatccaggt accttctcca atcctaaagc agacagcagg   3420

ttgaataaaa ccaatacaca acctattttc taggcaggag gggaaaaggc ccttaggaca   3480

ataatatttg tacaaagagt tgagagtaaa caaacagtgt atcaggttca aaaaaaaaaa   3540

aactattcgt tggcatttaa atttttttcc cttgcatagt atctattctc tcactaggac   3600

ttttaagtgc tctgctggag gctcagcgtt ggtaatacca tgtttgatgc aaacttgaac   3660

ccaatgctct cattggtggc acagctttgg agggtggtgg ccccaagaag gggcaatctg   3720

cctgctgcta tattaatctg gaaccagggc caacagctac tcttgaacta tggtatttga   3780

agagcgagtt cattgcctgt tttaccttaa atgacaggaa aggaagatga acaaaccttg   3840

ctttgccttg gcttcaaact agttcttgat ttaagacacc agaaagggag agagggagtc   3900

tgcttagagt ttgaggttgc ctctcacaag atgacagtta aaagttgcca ccttacttaa   3960

aaggcattaa ggaggcattt actcacaaag gagagagagt aaattttttt cttaagagga   4020

aaaaaatact gataatacat agaacaatct gcacatccag tcttggcact ttttccaatt   4080

tgactgatct ctaaactggt gacccttgca tatatcttag tctcttttct acaatcttct   4140

tcagaaagct acagcagcta acaatcatgt ataaagatgc atttcctaga tcatcttcag   4200

aagaaaatct cttcagcact ttccctagaa tctgtctcct gaccaccccg ccccagacct   4260

gctttctctt ttgagaattc ataaccaggt atgtttagat accagttcaa aagaccactc   4320

tatgggttga tgaggaaaag gctgcctgag gacaatttaa gaccataatg agtttccaat   4380

ttttaaagaa aatttggcta gctggctttt aattcttaat taaaatcatt aaatttaatt   4440

aaaattattc caatcaaaat atatcacttt ccaagattcc acattcatat tacttactta   4500

tactatggag actttctcta cctgagcatg tattcagggg ctataggtac atttaactct   4560

aactaactga aaaaaatcag gaagaaaaaa ctattaaaat aaaataacct cctaaatcat   4620

ttgggggtat ccccatcatt ggtgcgtgtg tctgcgtgtg tcaaacttta atgattattt   4680

attcagaccc tggaaaacca cactataaaa tagggcactg gatcacaagt tcgtttggtt   4740

aaaaaaaaaa aaaaaaaaaa gtgggggcgg ggggcagaga agaagtttaa cttggatgat   4800

ttccatgccc attccagctg taacattcta tgactgtgac ccagcctttg ttctcttttc   4860

tcactctcct actagacatt tcaatgaaaa gttaggcagg aaaaaggaaa ggaatcccaa   4920

gttgctgcca gctctgatga gagatcaggt tgggggagag attaggtggt tactgaattg   4980

aggtgtgggc ctcccctgac catgtcagtg atccacaacc cacctcactt cttggggctt   5040

aagctaaaag cagcttctga agagatgtta atgtcctgta atcactagag gagaaaattc   5100

attctccttc cataacatta cttagtaaag gaaaagcggt ggtgcaatca aattcacaaa   5160

taccaatggg gtctctaaaa tgtagaatgc agcttgctgg gtgctggtca gttttctaaa   5220

tgggaccaga aatggctttc ctaagaccat aaatgaactc tccagccaca catacattca   5280

aatgcattcc attagacatt gagctcctca agagcaggaa ctgctttatc tccacagtcc   5340

agctcagggt tggctcaagt ctgaagctca gtaaatgtct gtcaaataga aaagaaagga   5400

tgagccttcg gtcatcagct acatgagtca ggcacggtgg cagcttccca ttttagtcag   5460

tttgccagtt tgtaaccaga cagtaatcaa ttaagagctt taatctctta aggacatttt   5520

tcctttaggg aaaatgaaca aaaaataaaa catttattac cagtgctgct tccaagcaaa   5580

aatttaaaaa ttaaattaaa atttaaaaaa taagtgaagc cacttaggag tttccctggc   5640

aagcctcacc caagaagact taaccttttt taaaaagagg caaatagatt aaaggggcca   5700

ggggctggat gcataatccc ctgatctgat accaacccaa caggcccaga tgacttcttc   5760

cagcagatac aatcaatggg tcaagaacat tttctcaaag tttctttccc tctctatgga   5820

aaagagctga cagccccctt ctaagggcac cacatttcct ggatttcccc tcagactgac   5880

cttcaccctc ccccctaact tcccctttaa taataaaaaa acccagaatg catatataca   5940

aggaacagag taagacatgg gtaatttgta tggtgaactg ggcttcaatg atttgtgagg   6000

aatttgtttt gtgaaatcct gcacctctta ttctagctca caaacccttc ccatcgttct   6060

gtttccttcc ttgtcctttt ctgttccccc aaataataca catcaacata tcgactttta   6120

accaacttca gaatcatgga aggagagagg gagatttttc agaaagaaaa gcattcaggt   6180

tttagttatt aaggatggga agcatcttaa aattcagata ataccttagt ggtttttcct   6240

tcctccaaag ccaacctgat taaagatcaa ccctc                              6275


<210>  2791
<211>  415
<212>  PRT
<213>  Homo sapiens

<400>  2791


Met Leu Thr Gly Gln Ile Ala Lys Glu Asp Ala Val Leu Pro Val Ala 
1               5                   10                  15      


Leu Phe Pro Ser Leu Cys Glu Phe Val Phe His Asn Asn Pro Leu Val 
            20                  25                  30          


Ala His Thr Arg Gly Val Pro Pro Leu Leu Lys Ser Phe Leu Gln Glu 
        35                  40                  45              


Arg Leu Gly Ile His Leu Ile Arg Arg Lys Ile Val Lys Pro Lys His 
    50                  55                  60                  


His Val Leu Met Ser Arg Lys Glu Ser Trp Lys Val Lys Ser Glu Ile 
65                  70                  75                  80  


Pro Lys Val Pro Lys Gln Pro Leu Val Leu His His Pro Arg Met Thr 
                85                  90                  95      


Thr Thr Lys Ser Pro Ser Lys Asp Met Leu Glu Pro Glu Ala Glu Leu 
            100                 105                 110         


Ala Glu Asp Leu Pro Thr Thr Lys Ser Thr Ser Val Glu Ser Glu Met 
        115                 120                 125             


Pro Thr Glu Asn Leu Glu Gly His Ser Pro Ser Cys Arg Thr Phe Val 
    130                 135                 140                 


Pro Leu Pro Pro Ile Cys Ser Asn Ser Thr Val His Ser Glu Glu Thr 
145                 150                 155                 160 


Leu Ser His Leu Ser Asp Thr Thr Val Arg Leu Ser Pro Glu Arg Pro 
                165                 170                 175     


Ser Asp Glu Asp Ser Lys Ser Thr Glu Ser Ile Phe Leu Thr Gln Val 
            180                 185                 190         


Ser Glu Leu Pro Ser Ser Val Ile His Lys Asp Asp Leu Glu Leu Lys 
        195                 200                 205             


Glu Lys Asp Gln Lys Lys Pro Pro Thr Ala Pro Arg Glu Val Lys Gly 
    210                 215                 220                 


Thr Arg Arg Lys Leu Pro Thr Ala Phe Leu Pro Ser Lys Tyr His Gly 
225                 230                 235                 240 


Tyr Glu Glu Leu Leu Thr Ala Lys Pro Asp Pro Ala Phe Ile Glu Pro 
                245                 250                 255     


Lys Gly Ile Gln Lys Asn Ala Gln Ala Leu Gln Gln Met Leu Lys His 
            260                 265                 270         


Pro Leu Leu Cys His Ser Ser Lys Pro Lys Leu Asp Thr Leu Gln Lys 
        275                 280                 285             


Pro Tyr Val His Lys Glu Lys Arg Ala Gln Arg Ile Pro Ile Pro Pro 
    290                 295                 300                 


Pro Lys Lys Thr Arg Ala Gln Leu Leu Asp Asp Ile Phe Ile Arg Leu 
305                 310                 315                 320 


Arg Asp Pro Arg Asn Ile Thr Glu Ala Pro Leu Gly Ala Val Leu His 
                325                 330                 335     


Gln Trp Thr Glu Arg Arg Leu Val Asn His Lys Gln Tyr Leu Glu Ala 
            340                 345                 350         


Lys Arg Leu Leu Lys Glu Phe Gln Ala Arg Tyr Arg Gln Leu Val Ser 
        355                 360                 365             


Gly Ser Leu Arg Thr Val Phe Gly Thr Thr Pro Leu Pro Met Ala Cys 
    370                 375                 380                 


Pro Ala Leu Ser Glu Ser Gln Pro Lys Phe Gly His Phe Leu Glu Phe 
385                 390                 395                 400 


Met Asp Glu Phe Cys Gln Glu Pro Thr Ala Ser Asp Ser Gln Gly 
                405                 410                 415 

<210>  2792
<211>  6390
<212>  DNA
<213>  Homo sapiens

<400>  2792
gtcttgctgg cgcgaggtag tcagaggacg tggccgcggg gcttgctggg acttgaggtt     60

agacgtcccg gccgtcggtt gccgcctaca ctgtctgccg tcgcgtcgca gttactaagg    120

cgtggggaag atagcggcag gcaccgcagt ggagcggctc cgagatcccc ggggggctcg    180

caggcgcgca tccctcctga ctgggacgtc gcctccgcag acccctcgga ggctgaagcg    240

acgccggagg caggcaaaga aacaagtgaa gaaacaaaaa aaaaaggaag ttaaggggcc    300

attcccaaag tcaaagatca agccaaggac actggttagt ggttcagaaa ggtaacctca    360

agaagaagcc caagggtttg gttggagcac aagctgaacg tcgggaaagc ctgaaggcga    420

cttcttttga gttcaagggg aagaaagagt ctcggcggga aaatcaggtg gaccttcctg    480

gacatatcct ggaccaggct tttctgctga agcaccactg tgtgaggaag ccatcagatc    540

tgtgcaccat taatgtgagt ggcctgaagt tctccaaggc caaggaaaat gacttcaagc    600

attttcattc tgtgatttat atcaatgcct cagaaaacct gctgcctcta gaggcatttc    660

acacgtttcc agccctaaag gaactggatc tcgcatttaa tggcatcaaa actatctacg    720

tgaaatatgg agactttaag ttattagaat tcttggacct ttccttcaac agcctgactg    780

tggaggccat ctgtgatttg gggattctgc cacacctccg tgtcctgctc ctcacaggca    840

atggccttac ctccctgccg cccaatttgg ccgtcgcaga acaggaggca tctgtaacat    900

cgctgacaag caagaggtac atcctgaggt tcccagcgct ggagacactg atgctggatg    960

acaacagact ctccaacccc agttgctttg ccagcctggc tgggctcagg agactgaaga   1020

agttaagctt ggatgaaaac aggattatca ggatcccata cctacagcaa gttcagctct   1080

atgacgagtc agtagactgg aatggaggca ggggaagtcc ccataaagag ccccaattca   1140

tgctgcagtc caagccaagg atgcttgagg actcagatga gcaactggat tatactgtac   1200

tgcccatgaa aaaggatgtt gaccggacag atcgcaaaag aggatgctgt cctaccagta   1260

gctctcttcc catctctctg cgagttcgtc tttcataaca accctctggt ggcccataca   1320

cgaggggtcc ctccactgct gaagagcttc ctccaggagc gactgggaat ccacttaatt   1380

cgaaggaaga tagtaaagcc taagcatcat gttttgatgt ctcggaagga atcatggaag   1440

gtgaaaagcg aaatcccaaa ggtgccgaag cagcctctgg tgctccatca cccgcgcatg   1500

acgacaacca agtctccctc aaaggatatg ctagagccag aggcagagct ggctgaagat   1560

ctgcccacta ccaaaagcac ttctgtggag tcagagatgc ccactgagaa cctggaaggc   1620

cattccccgt cttgccggac cttcgtgcca ctgcctccca tctgctccaa ctccactgtg   1680

catagtgaag agaccctgtc ccacctgagt gacacaactg tccgcctcag cccagagcgc   1740

ccatcagatg aggactccaa gagcacagag tccatcttcc tgacccaggt gagtgaactg   1800

ccttcctccg tcatccataa ggatgattta gagttaaagg agaaagacca aaagaaacca   1860

ccaacggcac ccagagaggt gaaagggact cggaggaaac tcccaactgc cttccttccc   1920

agcaagtacc acggctatga agaactgctg acagccaagc ctgatccagc cttcattgag   1980

ccaaagggaa tccagaagaa tgcacaagcc ctgcaacaaa tgctgaagca cccactcctg   2040

tgccactcct ccaagcccaa gctggacact cttcagaaac cctatgttca caaagagaaa   2100

cgggcccaga gaatcccgat tccaccccca aagaagacta gagcccaact tctggatgac   2160

atcttcattc gcttgcggga tccccggaac attacagagg ctccactagg tgctgtcctg   2220

caccagtgga cagaacggcg gctggtgaac cacaagcagt acctggaggc caagaggctg   2280

ttgaaggagt tccaggcacg ttaccggcag ctggtgagtg gctctctgcg cacagtgttc   2340

gggactaccc cgctccccat ggcctgccca gcgctgagtg agagccagcc caagttcggc   2400

cacttcctcg agttcatgga tgagttctgc caggagccca cagccagtga ctcacaaggc   2460

tagagctgtg catgggggct gtgtgcacca cccggcctgt gccccagctc tccccgaggg   2520

ctctgtgccc tggaccgcac ctcaaggttg accagccggc cacaggcctc agagctcagc   2580

tgggccccac ttgctggcca caaggtggca tccccttgtc aggatctccc ctccttggcc   2640

caggcatgac ctggtgcctg gcccagcggc aataaagagt gggtgcacag ggcaatagac   2700

tgggtgccac atgcattctt tcttggaacc caggccacag cagcattgtc acacttccct   2760

ctaaaaatgg ttttccagtt cagatgcaac agggatacat ttgttctctg ttgtatgaga   2820

aactgacacc aaggggatct taacaaattc ctgaacaatg gctccaaaaa agggtatttt   2880

taaaaaccag atcttgtgag tacagcccta atgtgcaggg acagtgtcat cctgtatatt   2940

cgttctttac tcagactctt tcttggttcc ttcattagga gcatgaatgg ttgaatgtga   3000

acatgacagt aaattggagc aaactgtaaa ctggacataa cttatgccaa aagacgtagt   3060

tgtacaccat ggaaacccca tccctgctcc taatctctac tgccattctg aatgccaaag   3120

caagacatcc aacatggggc atctcccaga gcacatacag caccaaaaat ccacacacag   3180

cctaagctta acccatgttt ttgtctgaga ttgttcacca gagacaagac tctgactata   3240

aacagaacat ccactttcat gagtttcctt tactgtattc tcaacttggg ccttgcttca   3300

agcaggcaaa catacattga agaatgcact ttggtactgt ttaaataaca acacatcagc   3360

ccacttgatt ccatgccatg tccttgctga cagaaacatc cccaacaggg catgccctgg   3420

tccaagtcct ctgtctttgt caaaatgctc ttctgatgag ttggagagga ggcagccagc   3480

agtggcagtc cacaaggatc caggtacctt ctccaatcct aaagcagaca gcaggttgaa   3540

taaaaccaat acacaaccta ttttctaggc aggaggggaa aaggccctta ggacaataat   3600

atttgtacaa agagttgaga gtaaacaaac agtgtatcag gttcaaaaaa aaaaaaacta   3660

ttcgttggca tttaaatttt tttcccttgc atagtatcta ttctctcact aggactttta   3720

agtgctctgc tggaggctca gcgttggtaa taccatgttt gatgcaaact tgaacccaat   3780

gctctcattg gtggcacagc tttggagggt ggtggcccca agaaggggca atctgcctgc   3840

tgctatatta atctggaacc agggccaaca gctactcttg aactatggta tttgaagagc   3900

gagttcattg cctgttttac cttaaatgac aggaaaggaa gatgaacaaa ccttgctttg   3960

ccttggcttc aaactagttc ttgatttaag acaccagaaa gggagagagg gagtctgctt   4020

agagtttgag gttgcctctc acaagatgac agttaaaagt tgccacctta cttaaaaggc   4080

attaaggagg catttactca caaaggagag agagtaaatt tttttcttaa gaggaaaaaa   4140

atactgataa tacatagaac aatctgcaca tccagtcttg gcactttttc caatttgact   4200

gatctctaaa ctggtgaccc ttgcatatat cttagtctct tttctacaat cttcttcaga   4260

aagctacagc agctaacaat catgtataaa gatgcatttc ctagatcatc ttcagaagaa   4320

aatctcttca gcactttccc tagaatctgt ctcctgacca ccccgcccca gacctgcttt   4380

ctcttttgag aattcataac caggtatgtt tagataccag ttcaaaagac cactctatgg   4440

gttgatgagg aaaaggctgc ctgaggacaa tttaagacca taatgagttt ccaattttta   4500

aagaaaattt ggctagctgg cttttaattc ttaattaaaa tcattaaatt taattaaaat   4560

tattccaatc aaaatatatc actttccaag attccacatt catattactt acttatacta   4620

tggagacttt ctctacctga gcatgtattc aggggctata ggtacattta actctaacta   4680

actgaaaaaa atcaggaaga aaaaactatt aaaataaaat aacctcctaa atcatttggg   4740

ggtatcccca tcattggtgc gtgtgtctgc gtgtgtcaaa ctttaatgat tatttattca   4800

gaccctggaa aaccacacta taaaataggg cactggatca caagttcgtt tggttaaaaa   4860

aaaaaaaaaa aaaaagtggg ggcggggggc agagaagaag tttaacttgg atgatttcca   4920

tgcccattcc agctgtaaca ttctatgact gtgacccagc ctttgttctc ttttctcact   4980

ctcctactag acatttcaat gaaaagttag gcaggaaaaa ggaaaggaat cccaagttgc   5040

tgccagctct gatgagagat caggttgggg gagagattag gtggttactg aattgaggtg   5100

tgggcctccc ctgaccatgt cagtgatcca caacccacct cacttcttgg ggcttaagct   5160

aaaagcagct tctgaagaga tgttaatgtc ctgtaatcac tagaggagaa aattcattct   5220

ccttccataa cattacttag taaaggaaaa gcggtggtgc aatcaaattc acaaatacca   5280

atggggtctc taaaatgtag aatgcagctt gctgggtgct ggtcagtttt ctaaatggga   5340

ccagaaatgg ctttcctaag accataaatg aactctccag ccacacatac attcaaatgc   5400

attccattag acattgagct cctcaagagc aggaactgct ttatctccac agtccagctc   5460

agggttggct caagtctgaa gctcagtaaa tgtctgtcaa atagaaaaga aaggatgagc   5520

cttcggtcat cagctacatg agtcaggcac ggtggcagct tcccatttta gtcagtttgc   5580

cagtttgtaa ccagacagta atcaattaag agctttaatc tcttaaggac atttttcctt   5640

tagggaaaat gaacaaaaaa taaaacattt attaccagtg ctgcttccaa gcaaaaattt   5700

aaaaattaaa ttaaaattta aaaaataagt gaagccactt aggagtttcc ctggcaagcc   5760

tcacccaaga agacttaacc ttttttaaaa agaggcaaat agattaaagg ggccaggggc   5820

tggatgcata atcccctgat ctgataccaa cccaacaggc ccagatgact tcttccagca   5880

gatacaatca atgggtcaag aacattttct caaagtttct ttccctctct atggaaaaga   5940

gctgacagcc cccttctaag ggcaccacat ttcctggatt tcccctcaga ctgaccttca   6000

ccctcccccc taacttcccc tttaataata aaaaaaccca gaatgcatat atacaaggaa   6060

cagagtaaga catgggtaat ttgtatggtg aactgggctt caatgatttg tgaggaattt   6120

gttttgtgaa atcctgcacc tcttattcta gctcacaaac ccttcccatc gttctgtttc   6180

cttccttgtc cttttctgtt cccccaaata atacacatca acatatcgac ttttaaccaa   6240

cttcagaatc atggaaggag agagggagat ttttcagaaa gaaaagcatt caggttttag   6300

ttattaagga tgggaagcat cttaaaattc agataatacc ttagtggttt ttccttcctc   6360

caaagccaac ctgattaaag atcaaccctc                                    6390


<210>  2793
<211>  415
<212>  PRT
<213>  Homo sapiens

<400>  2793


Met Leu Thr Gly Gln Ile Ala Lys Glu Asp Ala Val Leu Pro Val Ala 
1               5                   10                  15      


Leu Phe Pro Ser Leu Cys Glu Phe Val Phe His Asn Asn Pro Leu Val 
            20                  25                  30          


Ala His Thr Arg Gly Val Pro Pro Leu Leu Lys Ser Phe Leu Gln Glu 
        35                  40                  45              


Arg Leu Gly Ile His Leu Ile Arg Arg Lys Ile Val Lys Pro Lys His 
    50                  55                  60                  


His Val Leu Met Ser Arg Lys Glu Ser Trp Lys Val Lys Ser Glu Ile 
65                  70                  75                  80  


Pro Lys Val Pro Lys Gln Pro Leu Val Leu His His Pro Arg Met Thr 
                85                  90                  95      


Thr Thr Lys Ser Pro Ser Lys Asp Met Leu Glu Pro Glu Ala Glu Leu 
            100                 105                 110         


Ala Glu Asp Leu Pro Thr Thr Lys Ser Thr Ser Val Glu Ser Glu Met 
        115                 120                 125             


Pro Thr Glu Asn Leu Glu Gly His Ser Pro Ser Cys Arg Thr Phe Val 
    130                 135                 140                 


Pro Leu Pro Pro Ile Cys Ser Asn Ser Thr Val His Ser Glu Glu Thr 
145                 150                 155                 160 


Leu Ser His Leu Ser Asp Thr Thr Val Arg Leu Ser Pro Glu Arg Pro 
                165                 170                 175     


Ser Asp Glu Asp Ser Lys Ser Thr Glu Ser Ile Phe Leu Thr Gln Val 
            180                 185                 190         


Ser Glu Leu Pro Ser Ser Val Ile His Lys Asp Asp Leu Glu Leu Lys 
        195                 200                 205             


Glu Lys Asp Gln Lys Lys Pro Pro Thr Ala Pro Arg Glu Val Lys Gly 
    210                 215                 220                 


Thr Arg Arg Lys Leu Pro Thr Ala Phe Leu Pro Ser Lys Tyr His Gly 
225                 230                 235                 240 


Tyr Glu Glu Leu Leu Thr Ala Lys Pro Asp Pro Ala Phe Ile Glu Pro 
                245                 250                 255     


Lys Gly Ile Gln Lys Asn Ala Gln Ala Leu Gln Gln Met Leu Lys His 
            260                 265                 270         


Pro Leu Leu Cys His Ser Ser Lys Pro Lys Leu Asp Thr Leu Gln Lys 
        275                 280                 285             


Pro Tyr Val His Lys Glu Lys Arg Ala Gln Arg Ile Pro Ile Pro Pro 
    290                 295                 300                 


Pro Lys Lys Thr Arg Ala Gln Leu Leu Asp Asp Ile Phe Ile Arg Leu 
305                 310                 315                 320 


Arg Asp Pro Arg Asn Ile Thr Glu Ala Pro Leu Gly Ala Val Leu His 
                325                 330                 335     


Gln Trp Thr Glu Arg Arg Leu Val Asn His Lys Gln Tyr Leu Glu Ala 
            340                 345                 350         


Lys Arg Leu Leu Lys Glu Phe Gln Ala Arg Tyr Arg Gln Leu Val Ser 
        355                 360                 365             


Gly Ser Leu Arg Thr Val Phe Gly Thr Thr Pro Leu Pro Met Ala Cys 
    370                 375                 380                 


Pro Ala Leu Ser Glu Ser Gln Pro Lys Phe Gly His Phe Leu Glu Phe 
385                 390                 395                 400 


Met Asp Glu Phe Cys Gln Glu Pro Thr Ala Ser Asp Ser Gln Gly 
                405                 410                 415 

<210>  2794
<211>  6149
<212>  DNA
<213>  Homo sapiens

<400>  2794
gtcttgctgg cgcgaggtag tcagaggacg tggccgcggg gcttgctggg acttgaggtt     60

agacgtcccg gccgtcggtt gccgcctaca ctgtctgccg tcgcgtcgca gttactaagg    120

cgtggggaag atagcggcag gcaccgcagt ggagcggctc cgagatcccc ggggggctcg    180

caggcgcgca tccctcctga ctgggacgtc gcctccgcag acccctcgga ggctgaagcg    240

acgccggagg caggcaaaga aacaagtgaa gaaacaaaaa aaaaaggaag ttaaggggcc    300

attcccaaag tcaaagatca agccaaggac actggttagt ggttcagaaa ggtaacctca    360

agaagaagcc caagggtttg gttggagcac aagctgaacg tcgggaaagc ctgaaggcga    420

cttcttttga gttcaagggg aagaaagagt ctcggcggga aaatcaggtg gaccttcctg    480

gacatatcct ggaccaggct tttctgctga agcaccactg tgtgaggaag ccatcagatc    540

tgtgcaccat taatgtgagt ggcctgaagt tctccaaggc caaggaaaat gacttcaagc    600

attttcattc tgtgatttat atcaatgcct cagaaaacct gctgcctcta gttcttggac    660

ctttccttca acagcctgac tgtggaggcc atctgtgatt tggggattct gccacacctc    720

cgtgtcctgc tcctcacagg caatggcctt acctccctgc cgcccaattt ggccgtcgca    780

gaacaggagg catctgtaac atcgctgaca agcaagaggt acatcctgag gttcccagcg    840

ctggagacac tgatgctgga tgacaacaga ctctccaacc ccagttgctt tgccagcctg    900

gctgggctca ggagactgaa gaagttaagc ttggatgaaa acaggattat caggatccca    960

tacctacagc aagttcagct ctatgacgag tcagtagact ggaatggagg caggggaagt   1020

ccccataaag agccccaatt catgctgcag tccaagccaa ggatgcttga ggactcagat   1080

gagcaactgg attatactgt actgcccatg aaaaaggatg ttgaccggac agatcgcaaa   1140

agaggatgct gtcctaccag tagctctctt cccatctctc aggggtccct ccactgctga   1200

agagcttcct ccaggagcga ctgggaatcc acttaattcg aaggaagata gtaaagccta   1260

agcatcatgt tttgatgtct cggaaggaat catggaaggt gaaaagcgaa atcccaaagg   1320

tgccgaagca gcctctggtg ctccatcacc cgcgcatgac gacaaccaag tctccctcaa   1380

aggatatgct agagccagag gcagagctgg ctgaagatct gcccactacc aaaagcactt   1440

ctgtggagtc agagatgccc actgagaacc tggaaggcca ttccccgtct tgccggacct   1500

tcgtgccact gcctcccatc tgctccaact ccactgtgca tagtgaagag accctgtccc   1560

acctgagtga cacaactgtc cgcctcagcc cagagcgccc atcagatgag gactccaaga   1620

gcacagagtc catcttcctg acccaggtga gtgaactgcc ttcctccgtc atccataagg   1680

atgatttaga gttaaaggag aaagaccaaa agaaaccacc aacggcaccc agagaggtga   1740

aagggactcg gaggaaactc ccaactgcct tccttcccag caagtaccac ggctatgaag   1800

aactgctgac agccaagcct gatccagcct tcattgagcc aaagggaatc cagaagaatg   1860

cacaagccct gcaacaaatg ctgaagcacc cactcctgtg ccactcctcc aagcccaagc   1920

tggacactct tcagaaaccc tatgttcaca aagagaaacg ggcccagaga atcccgattc   1980

cacccccaaa gaagactaga gcccaacttc tggatgacat cttcattcgc ttgcgggatc   2040

cccggaacat tacagaggct ccactaggtg ctgtcctgca ccagtggaca gaacggcggc   2100

tggtgaacca caagcagtac ctggaggcca agaggctgtt gaaggagttc caggcacgtt   2160

accggcagct ggtgagtggc tctctgcgca cagtgttcgg gactaccccg ctccccatgg   2220

cctgcccagc gctgagtgag agccagccca agttcggcca cttcctcgag ttcatggatg   2280

agttctgcca ggagcccaca gccagtgact cacaaggcta gagctgtgca tgggggctgt   2340

gtgcaccacc cggcctgtgc cccagctctc cccgagggct ctgtgccctg gaccgcacct   2400

caaggttgac cagccggcca caggcctcag agctcagctg ggccccactt gctggccaca   2460

aggtggcatc cccttgtcag gatctcccct ccttggccca ggcatgacct ggtgcctggc   2520

ccagcggcaa taaagagtgg gtgcacaggg caatagactg ggtgccacat gcattctttc   2580

ttggaaccca ggccacagca gcattgtcac acttccctct aaaaatggtt ttccagttca   2640

gatgcaacag ggatacattt gttctctgtt gtatgagaaa ctgacaccaa ggggatctta   2700

acaaattcct gaacaatggc tccaaaaaag ggtattttta aaaaccagat cttgtgagta   2760

cagccctaat gtgcagggac agtgtcatcc tgtatattcg ttctttactc agactctttc   2820

ttggttcctt cattaggagc atgaatggtt gaatgtgaac atgacagtaa attggagcaa   2880

actgtaaact ggacataact tatgccaaaa gacgtagttg tacaccatgg aaaccccatc   2940

cctgctccta atctctactg ccattctgaa tgccaaagca agacatccaa catggggcat   3000

ctcccagagc acatacagca ccaaaaatcc acacacagcc taagcttaac ccatgttttt   3060

gtctgagatt gttcaccaga gacaagactc tgactataaa cagaacatcc actttcatga   3120

gtttccttta ctgtattctc aacttgggcc ttgcttcaag caggcaaaca tacattgaag   3180

aatgcacttt ggtactgttt aaataacaac acatcagccc acttgattcc atgccatgtc   3240

cttgctgaca gaaacatccc caacagggca tgccctggtc caagtcctct gtctttgtca   3300

aaatgctctt ctgatgagtt ggagaggagg cagccagcag tggcagtcca caaggatcca   3360

ggtaccttct ccaatcctaa agcagacagc aggttgaata aaaccaatac acaacctatt   3420

ttctaggcag gaggggaaaa ggcccttagg acaataatat ttgtacaaag agttgagagt   3480

aaacaaacag tgtatcaggt tcaaaaaaaa aaaaactatt cgttggcatt taaatttttt   3540

tcccttgcat agtatctatt ctctcactag gacttttaag tgctctgctg gaggctcagc   3600

gttggtaata ccatgtttga tgcaaacttg aacccaatgc tctcattggt ggcacagctt   3660

tggagggtgg tggccccaag aaggggcaat ctgcctgctg ctatattaat ctggaaccag   3720

ggccaacagc tactcttgaa ctatggtatt tgaagagcga gttcattgcc tgttttacct   3780

taaatgacag gaaaggaaga tgaacaaacc ttgctttgcc ttggcttcaa actagttctt   3840

gatttaagac accagaaagg gagagaggga gtctgcttag agtttgaggt tgcctctcac   3900

aagatgacag ttaaaagttg ccaccttact taaaaggcat taaggaggca tttactcaca   3960

aaggagagag agtaaatttt tttcttaaga ggaaaaaaat actgataata catagaacaa   4020

tctgcacatc cagtcttggc actttttcca atttgactga tctctaaact ggtgaccctt   4080

gcatatatct tagtctcttt tctacaatct tcttcagaaa gctacagcag ctaacaatca   4140

tgtataaaga tgcatttcct agatcatctt cagaagaaaa tctcttcagc actttcccta   4200

gaatctgtct cctgaccacc ccgccccaga cctgctttct cttttgagaa ttcataacca   4260

ggtatgttta gataccagtt caaaagacca ctctatgggt tgatgaggaa aaggctgcct   4320

gaggacaatt taagaccata atgagtttcc aatttttaaa gaaaatttgg ctagctggct   4380

tttaattctt aattaaaatc attaaattta attaaaatta ttccaatcaa aatatatcac   4440

tttccaagat tccacattca tattacttac ttatactatg gagactttct ctacctgagc   4500

atgtattcag gggctatagg tacatttaac tctaactaac tgaaaaaaat caggaagaaa   4560

aaactattaa aataaaataa cctcctaaat catttggggg tatccccatc attggtgcgt   4620

gtgtctgcgt gtgtcaaact ttaatgatta tttattcaga ccctggaaaa ccacactata   4680

aaatagggca ctggatcaca agttcgtttg gttaaaaaaa aaaaaaaaaa aaagtggggg   4740

cggggggcag agaagaagtt taacttggat gatttccatg cccattccag ctgtaacatt   4800

ctatgactgt gacccagcct ttgttctctt ttctcactct cctactagac atttcaatga   4860

aaagttaggc aggaaaaagg aaaggaatcc caagttgctg ccagctctga tgagagatca   4920

ggttggggga gagattaggt ggttactgaa ttgaggtgtg ggcctcccct gaccatgtca   4980

gtgatccaca acccacctca cttcttgggg cttaagctaa aagcagcttc tgaagagatg   5040

ttaatgtcct gtaatcacta gaggagaaaa ttcattctcc ttccataaca ttacttagta   5100

aaggaaaagc ggtggtgcaa tcaaattcac aaataccaat ggggtctcta aaatgtagaa   5160

tgcagcttgc tgggtgctgg tcagttttct aaatgggacc agaaatggct ttcctaagac   5220

cataaatgaa ctctccagcc acacatacat tcaaatgcat tagaaaagaa aggatgagcc   5280

ttcggtcatc agctacatga gtcaggcacg gtggcagctt cccattttag tcagtttgcc   5340

agtttgtaac cagacagtaa tcaattaaga gctttaatct cttaaggaca tttttccttt   5400

agggaaaatg aacaaaaaat aaaacattta ttaccagtgc tgcttccaag caaaaattta   5460

aaaattaaat taaaatttaa aaaataagtg aagccactta ggagtttccc tggcaagcct   5520

cacccaagaa gacttaacct tttttaaaaa gaggcaaata gattaaaggg gccaggggct   5580

ggatgcataa tcccctgatc tgataccaac ccaacaggcc cagatgactt cttccagcag   5640

atacaatcaa tgggtcaaga acattttctc aaagtttctt tccctctcta tggaaaagag   5700

ctgacagccc ccttctaagg gcaccacatt tcctggattt cccctcagac tgaccttcac   5760

cctcccccct aacttcccct ttaataataa aaaaacccag aatgcatata tacaaggaac   5820

agagtaagac atgggtaatt tgtatggtga actgggcttc aatgatttgt gaggaatttg   5880

ttttgtgaaa tcctgcacct cttattctag ctcacaaacc cttcccatcg ttctgtttcc   5940

ttccttgtcc ttttctgttc ccccaaataa tacacatcaa catatcgact tttaaccaac   6000

ttcagaatca tggaaggaga gagggagatt tttcagaaag aaaagcattc aggttttagt   6060

tattaaggat gggaagcatc ttaaaattca gataatacct tagtggtttt tccttcctcc   6120

aaagccaacc tgattaaaga tcaaccctc                                     6149


<210>  2795
<211>  348
<212>  PRT
<213>  Homo sapiens

<400>  2795


Met Ser Arg Lys Glu Ser Trp Lys Val Lys Ser Glu Ile Pro Lys Val 
1               5                   10                  15      


Pro Lys Gln Pro Leu Val Leu His His Pro Arg Met Thr Thr Thr Lys 
            20                  25                  30          


Ser Pro Ser Lys Asp Met Leu Glu Pro Glu Ala Glu Leu Ala Glu Asp 
        35                  40                  45              


Leu Pro Thr Thr Lys Ser Thr Ser Val Glu Ser Glu Met Pro Thr Glu 
    50                  55                  60                  


Asn Leu Glu Gly His Ser Pro Ser Cys Arg Thr Phe Val Pro Leu Pro 
65                  70                  75                  80  


Pro Ile Cys Ser Asn Ser Thr Val His Ser Glu Glu Thr Leu Ser His 
                85                  90                  95      


Leu Ser Asp Thr Thr Val Arg Leu Ser Pro Glu Arg Pro Ser Asp Glu 
            100                 105                 110         


Asp Ser Lys Ser Thr Glu Ser Ile Phe Leu Thr Gln Val Ser Glu Leu 
        115                 120                 125             


Pro Ser Ser Val Ile His Lys Asp Asp Leu Glu Leu Lys Glu Lys Asp 
    130                 135                 140                 


Gln Lys Lys Pro Pro Thr Ala Pro Arg Glu Val Lys Gly Thr Arg Arg 
145                 150                 155                 160 


Lys Leu Pro Thr Ala Phe Leu Pro Ser Lys Tyr His Gly Tyr Glu Glu 
                165                 170                 175     


Leu Leu Thr Ala Lys Pro Asp Pro Ala Phe Ile Glu Pro Lys Gly Ile 
            180                 185                 190         


Gln Lys Asn Ala Gln Ala Leu Gln Gln Met Leu Lys His Pro Leu Leu 
        195                 200                 205             


Cys His Ser Ser Lys Pro Lys Leu Asp Thr Leu Gln Lys Pro Tyr Val 
    210                 215                 220                 


His Lys Glu Lys Arg Ala Gln Arg Ile Pro Ile Pro Pro Pro Lys Lys 
225                 230                 235                 240 


Thr Arg Ala Gln Leu Leu Asp Asp Ile Phe Ile Arg Leu Arg Asp Pro 
                245                 250                 255     


Arg Asn Ile Thr Glu Ala Pro Leu Gly Ala Val Leu His Gln Trp Thr 
            260                 265                 270         


Glu Arg Arg Leu Val Asn His Lys Gln Tyr Leu Glu Ala Lys Arg Leu 
        275                 280                 285             


Leu Lys Glu Phe Gln Ala Arg Tyr Arg Gln Leu Val Ser Gly Ser Leu 
    290                 295                 300                 


Arg Thr Val Phe Gly Thr Thr Pro Leu Pro Met Ala Cys Pro Ala Leu 
305                 310                 315                 320 


Ser Glu Ser Gln Pro Lys Phe Gly His Phe Leu Glu Phe Met Asp Glu 
                325                 330                 335     


Phe Cys Gln Glu Pro Thr Ala Ser Asp Ser Gln Gly 
            340                 345             

<210>  2796
<211>  6295
<212>  DNA
<213>  Homo sapiens

<400>  2796
agtttgggtc ttgctggcgc gaggtagtca gaggacgtgg ccgcggggct tgctgggact     60

tgaggttaga cgtcccggcc gtcggttgcc gcctacactg tctgccgtcg cgtcgcagtt    120

actaaggcgt ggggaagata gcggcaggca ccgcagtgga gcggctccga gatccccggg    180

gggctcgcag gcgcgcatcc ctcctgactg ggacgtcgcc tccgcagacc cctcggaggc    240

tgaagcgacg ccggaggcag gcaaagaaac aagtgaagaa acaaaaaaaa aaggaagtta    300

aggggccatt cccaaagtca aagatcaagg agatggcctt ctcaggaatc tacaagctgg    360

atgatgggaa gccttacctg aacaactgct tcccagccag aaatctgctt cgcgtgccgg    420

aggaaggcca aggacactgg ttagtggttc agaaaggtaa cctcaagaag aagcccaagg    480

gtttggttgg agcacaagct gaacgtcggg aaagcctgaa ggcgacttct tttgagttca    540

aggggaagaa agagtctcgg cgggaaaatc aggtggacct tcctggacat atcctggacc    600

aggcttttct gctgaagcac cactgtgtga ggaagccatc agatctgtgc accattaatg    660

tgagtggcct gaagttctcc aaggccaagg aaaatgactt caagcatttt cattctgtga    720

tttatatcaa tgcctcagaa aacctgctgc ctctagaggc atttcacacg tttccagccc    780

taaaggaact ggatctcgca tttaatggca tcaaaactat ctacgtgaaa tatggagact    840

ttaagttatt agaattcttg gacctttcct tcaacagcct gactgtggag gccatctgtg    900

atttggggat tctgccacac ctccgtgtcc tgctcctcac aggcaatggc cttacctccc    960

tgccgcccaa tttggccgtc gcagaacagg aggcatctgt aacatcgctg acaagcaaga   1020

ggtacatcct gaggttccca gcgctggaga cactgatgct ggatgacaac agactctcca   1080

accccagttg ctttgccagc ctggctgggc tcaggagact gaagaagtta agcttggatg   1140

aaaacaggat tatcaggatc ccatacctac agcaagttca gctctatgac gagtcagtag   1200

actggaatgg aggcagggga agtccccata aagagcccca attcatgctg cagtccaagc   1260

caaggatgct tgaggactca gatgagcaac tggattatac tgtactgccc atgaaaaagg   1320

atgttgaccg gacaggggtc cctccactgc tgaagagctt cctccaggag cgactgggaa   1380

tccacttaat tcgaaggaag atagtaaagc ctaagcatca tgttttgatg tctcggaagg   1440

aatcatggaa ggtgaaaagc gaaatcccaa aggtgccgaa gcagcctctg gtgctccatc   1500

acccgcgcat gacgacaacc aagtctccct caaaggatat gctagagcca gaggcagagc   1560

tggctgaaga tctgcccact accaaaagca cttctgtgga gtcagagatg cccactgaga   1620

acctggaagg ccattccccg tcttgccgga ccttcgtgcc actgcctccc atctgctcca   1680

actccactgt gcatagtgaa gagaccctgt cccacctgag tgacacaact gtccgcctca   1740

gcccagagcg cccatcagat gaggactcca agagcacaga gtccatcttc ctgacccagg   1800

tgagtgaact gccttcctcc gtcatccata aggatgattt agagttaaag gagaaagacc   1860

aaaagaaacc accaacggca cccagagagg tgaaagggac tcggaggaaa ctcccaactg   1920

ccttccttcc cagcaagtac cacggctatg aagaactgct gacagccaag cctgatccag   1980

ccttcattga gccaaaggga atccagaaga atgcacaagc cctgcaacaa atgctgaagc   2040

acccactcct gtgccactcc tccaagccca agctggacac tcttcagaaa ccctatgttc   2100

acaaagagaa acgggtgctg tcctgcacca gtggacagaa cggcggctgg tgaaccacaa   2160

gcagtacctg gaggccaaga ggctgttgaa ggagttccag gcacgttacc ggcagctggt   2220

gagtggctct ctgcgcacag tgttcgggac taccccgctc cccatggcct gcccagcgct   2280

gagtgagagc cagcccaagt tcggccactt cctcgagttc atggatgagt tctgccagga   2340

gcccacagcc agtgactcac aaggctagag ctgtgcatgg gggctgtgtg caccacccgg   2400

cctgtgcccc agctctcccc gagggctctg tgccctggac cgcacctcaa ggttgaccag   2460

ccggccacag gcctcagagc tcagctgggc cccacttgct ggccacaagg tggcatcccc   2520

ttgtcaggat ctcccctcct tggcccaggc atgacctggt gcctggccca gcggcaataa   2580

agagtgggtg cacagggcaa tagactgggt gccacatgca ttctttcttg gaacccaggc   2640

cacagcagca ttgtcacact tccctctaaa aatggttttc cagttcagat gcaacaggga   2700

tacatttgtt ctctgttgta tgagaaactg acaccaaggg gatcttaaca aattcctgaa   2760

caatggctcc aaaaaagggt atttttaaaa accagatctt gtgagtacag ccctaatgtg   2820

cagggacagt gtcatcctgt atattcgttc tttactcaga ctctttcttg gttccttcat   2880

taggagcatg aatggttgaa tgtgaacatg acagtaaatt ggagcaaact gtaaactgga   2940

cataacttat gccaaaagac gtagttgtac accatggaaa ccccatccct gctcctaatc   3000

tctactgcca ttctgaatgc caaagcaaga catccaacat ggggcatctc ccagagcaca   3060

tacagcacca aaaatccaca cacagcctaa gcttaaccca tgtttttgtc tgagattgtt   3120

caccagagac aagactctga ctataaacag aacatccact ttcatgagtt tcctttactg   3180

tattctcaac ttgggccttg cttcaagcag gcaaacatac attgaagaat gcactttggt   3240

actgtttaaa taacaacaca tcagcccact tgattccatg ccatgtcctt gctgacagaa   3300

acatccccaa cagggcatgc cctggtccaa gtcctctgtc tttgtcaaaa tgctcttctg   3360

atgagttgga gaggaggcag ccagcagtgg cagtccacaa ggatccaggt accttctcca   3420

atcctaaagc agacagcagg ttgaataaaa ccaatacaca acctattttc taggcaggag   3480

gggaaaaggc ccttaggaca ataatatttg tacaaagagt tgagagtaaa caaacagtgt   3540

atcaggttca aaaaaaaaaa aactattcgt tggcatttaa atttttttcc cttgcatagt   3600

atctattctc tcactaggac ttttaagtgc tctgctggag gctcagcgtt ggtaatacca   3660

tgtttgatgc aaacttgaac ccaatgctct cattggtggc acagctttgg agggtggtgg   3720

ccccaagaag gggcaatctg cctgctgcta tattaatctg gaaccagggc caacagctac   3780

tcttgaacta tggtatttga agagcgagtt cattgcctgt tttaccttaa atgacaggaa   3840

aggaagatga acaaaccttg ctttgccttg gcttcaaact agttcttgat ttaagacacc   3900

agaaagggag agagggagtc tgcttagagt ttgaggttgc ctctcacaag atgacagtta   3960

aaagttgcca ccttacttaa aaggcattaa ggaggcattt actcacaaag gagagagagt   4020

aaattttttt cttaagagga aaaaaatact gataatacat agaacaatct gcacatccag   4080

tcttggcact ttttccaatt tgactgatct ctaaactggt gacccttgca tatatcttag   4140

tctcttttct acaatcttct tcagaaagct acagcagcta acaatcatgt ataaagatgc   4200

atttcctaga tcatcttcag aagaaaatct cttcagcact ttccctagaa tctgtctcct   4260

gaccaccccg ccccagacct gctttctctt ttgagaattc ataaccaggt atgtttagat   4320

accagttcaa aagaccactc tatgggttga tgaggaaaag gctgcctgag gacaatttaa   4380

gaccataatg agtttccaat ttttaaagaa aatttggcta gctggctttt aattcttaat   4440

taaaatcatt aaatttaatt aaaattattc caatcaaaat atatcacttt ccaagattcc   4500

acattcatat tacttactta tactatggag actttctcta cctgagcatg tattcagggg   4560

ctataggtac atttaactct aactaactga aaaaaatcag gaagaaaaaa ctattaaaat   4620

aaaataacct cctaaatcat ttgggggtat ccccatcatt ggtgcgtgtg tctgcgtgtg   4680

tcaaacttta atgattattt attcagaccc tggaaaacca cactataaaa tagggcactg   4740

gatcacaagt tcgtttggtt aaaaaaaaaa aaaaaaaaaa gtgggggcgg ggggcagaga   4800

agaagtttaa cttggatgat ttccatgccc attccagctg taacattcta tgactgtgac   4860

ccagcctttg ttctcttttc tcactctcct actagacatt tcaatgaaaa gttaggcagg   4920

aaaaaggaaa ggaatcccaa gttgctgcca gctctgatga gagatcaggt tgggggagag   4980

attaggtggt tactgaattg aggtgtgggc ctcccctgac catgtcagtg atccacaacc   5040

cacctcactt cttggggctt aagctaaaag cagcttctga agagatgtta atgtcctgta   5100

atcactagag gagaaaattc attctccttc cataacatta cttagtaaag gaaaagcggt   5160

ggtgcaatca aattcacaaa taccaatggg gtctctaaaa tgtagaatgc agcttgctgg   5220

gtgctggtca gttttctaaa tgggaccaga aatggctttc ctaagaccat aaatgaactc   5280

tccagccaca catacattca aatgcattcc attagacatt gagctcctca agagcaggaa   5340

ctgctttatc tccacagtcc agctcagggt tggctcaagt ctgaagctca gtaaatgtct   5400

gtcaaataga aaagaaagga tgagccttcg gtcatcagct acatgagtca ggcacggtgg   5460

cagcttccca ttttagtcag tttgccagtt tgtaaccaga cagtaatcaa ttaagagctt   5520

taatctctta aggacatttt tcctttaggg aaaatgaaca aaaaataaaa catttattac   5580

cagtgctgct tccaagcaaa aatttaaaaa ttaaattaaa atttaaaaaa taagtgaagc   5640

cacttaggag tttccctggc aagcctcacc caagaagact taaccttttt taaaaagagg   5700

caaatagatt aaaggggcca ggggctggat gcataatccc ctgatctgat accaacccaa   5760

caggcccaga tgacttcttc cagcagatac aatcaatggg tcaagaacat tttctcaaag   5820

tttctttccc tctctatgga aaagagctga cagccccctt ctaagggcac cacatttcct   5880

ggatttcccc tcagactgac cttcaccctc ccccctaact tcccctttaa taataaaaaa   5940

acccagaatg catatataca aggaacagag taagacatgg gtaatttgta tggtgaactg   6000

ggcttcaatg atttgtgagg aatttgtttt gtgaaatcct gcacctctta ttctagctca   6060

caaacccttc ccatcgttct gtttccttcc ttgtcctttt ctgttccccc aaataataca   6120

catcaacata tcgactttta accaacttca gaatcatgga aggagagagg gagatttttc   6180

agaaagaaaa gcattcaggt tttagttatt aaggatggga agcatcttaa aattcagata   6240

ataccttagt ggtttttcct tcctccaaag ccaacctgat taaagatcaa ccctc        6295


<210>  2797
<211>  606
<212>  PRT
<213>  Homo sapiens

<400>  2797


Met Ala Phe Ser Gly Ile Tyr Lys Leu Asp Asp Gly Lys Pro Tyr Leu 
1               5                   10                  15      


Asn Asn Cys Phe Pro Ala Arg Asn Leu Leu Arg Val Pro Glu Glu Gly 
            20                  25                  30          


Gln Gly His Trp Leu Val Val Gln Lys Gly Asn Leu Lys Lys Lys Pro 
        35                  40                  45              


Lys Gly Leu Val Gly Ala Gln Ala Glu Arg Arg Glu Ser Leu Lys Ala 
    50                  55                  60                  


Thr Ser Phe Glu Phe Lys Gly Lys Lys Glu Ser Arg Arg Glu Asn Gln 
65                  70                  75                  80  


Val Asp Leu Pro Gly His Ile Leu Asp Gln Ala Phe Leu Leu Lys His 
                85                  90                  95      


His Cys Val Arg Lys Pro Ser Asp Leu Cys Thr Ile Asn Val Ser Gly 
            100                 105                 110         


Leu Lys Phe Ser Lys Ala Lys Glu Asn Asp Phe Lys His Phe His Ser 
        115                 120                 125             


Val Ile Tyr Ile Asn Ala Ser Glu Asn Leu Leu Pro Leu Glu Ala Phe 
    130                 135                 140                 


His Thr Phe Pro Ala Leu Lys Glu Leu Asp Leu Ala Phe Asn Gly Ile 
145                 150                 155                 160 


Lys Thr Ile Tyr Val Lys Tyr Gly Asp Phe Lys Leu Leu Glu Phe Leu 
                165                 170                 175     


Asp Leu Ser Phe Asn Ser Leu Thr Val Glu Ala Ile Cys Asp Leu Gly 
            180                 185                 190         


Ile Leu Pro His Leu Arg Val Leu Leu Leu Thr Gly Asn Gly Leu Thr 
        195                 200                 205             


Ser Leu Pro Pro Asn Leu Ala Val Ala Glu Gln Glu Ala Ser Val Thr 
    210                 215                 220                 


Ser Leu Thr Ser Lys Arg Tyr Ile Leu Arg Phe Pro Ala Leu Glu Thr 
225                 230                 235                 240 


Leu Met Leu Asp Asp Asn Arg Leu Ser Asn Pro Ser Cys Phe Ala Ser 
                245                 250                 255     


Leu Ala Gly Leu Arg Arg Leu Lys Lys Leu Ser Leu Asp Glu Asn Arg 
            260                 265                 270         


Ile Ile Arg Ile Pro Tyr Leu Gln Gln Val Gln Leu Tyr Asp Glu Ser 
        275                 280                 285             


Val Asp Trp Asn Gly Gly Arg Gly Ser Pro His Lys Glu Pro Gln Phe 
    290                 295                 300                 


Met Leu Gln Ser Lys Pro Arg Met Leu Glu Asp Ser Asp Glu Gln Leu 
305                 310                 315                 320 


Asp Tyr Thr Val Leu Pro Met Lys Lys Asp Val Asp Arg Thr Gly Val 
                325                 330                 335     


Pro Pro Leu Leu Lys Ser Phe Leu Gln Glu Arg Leu Gly Ile His Leu 
            340                 345                 350         


Ile Arg Arg Lys Ile Val Lys Pro Lys His His Val Leu Met Ser Arg 
        355                 360                 365             


Lys Glu Ser Trp Lys Val Lys Ser Glu Ile Pro Lys Val Pro Lys Gln 
    370                 375                 380                 


Pro Leu Val Leu His His Pro Arg Met Thr Thr Thr Lys Ser Pro Ser 
385                 390                 395                 400 


Lys Asp Met Leu Glu Pro Glu Ala Glu Leu Ala Glu Asp Leu Pro Thr 
                405                 410                 415     


Thr Lys Ser Thr Ser Val Glu Ser Glu Met Pro Thr Glu Asn Leu Glu 
            420                 425                 430         


Gly His Ser Pro Ser Cys Arg Thr Phe Val Pro Leu Pro Pro Ile Cys 
        435                 440                 445             


Ser Asn Ser Thr Val His Ser Glu Glu Thr Leu Ser His Leu Ser Asp 
    450                 455                 460                 


Thr Thr Val Arg Leu Ser Pro Glu Arg Pro Ser Asp Glu Asp Ser Lys 
465                 470                 475                 480 


Ser Thr Glu Ser Ile Phe Leu Thr Gln Val Ser Glu Leu Pro Ser Ser 
                485                 490                 495     


Val Ile His Lys Asp Asp Leu Glu Leu Lys Glu Lys Asp Gln Lys Lys 
            500                 505                 510         


Pro Pro Thr Ala Pro Arg Glu Val Lys Gly Thr Arg Arg Lys Leu Pro 
        515                 520                 525             


Thr Ala Phe Leu Pro Ser Lys Tyr His Gly Tyr Glu Glu Leu Leu Thr 
    530                 535                 540                 


Ala Lys Pro Asp Pro Ala Phe Ile Glu Pro Lys Gly Ile Gln Lys Asn 
545                 550                 555                 560 


Ala Gln Ala Leu Gln Gln Met Leu Lys His Pro Leu Leu Cys His Ser 
                565                 570                 575     


Ser Lys Pro Lys Leu Asp Thr Leu Gln Lys Pro Tyr Val His Lys Glu 
            580                 585                 590         


Lys Arg Val Leu Ser Cys Thr Ser Gly Gln Asn Gly Gly Trp 
        595                 600                 605     

<210>  2798
<211>  6401
<212>  DNA
<213>  Homo sapiens

<400>  2798
agtttgggtc ttgctggcgc gaggtagtca gaggacgtgg ccgcggggct tgctgggact     60

tgaggttaga cgtcccggcc gtcggttgcc gcctacactg tctgccgtcg cgtcgcagtt    120

actaaggcgt ggggaagata gcggcaggca ccgcagtgga gcggctccga gatccccggg    180

gggctcgcag gcgcgcatcc ctcctgactg ggacgtcgcc tccgcagacc cctcggaggc    240

tgaagcgacg ccggaggcag gcaaagaaac aagtgaagaa acaaaaaaaa aaggaagtta    300

aggggccatt cccaaagtca aagatcaagg agatggcctt ctcaggaatc tacaagctgg    360

atgatgggaa gccttacctg aacaactgct tcccagccag aaatctgctt cgcgtgccgg    420

aggaaggcca aggacactgg ttagtggttc agaaaggtaa cctcaagaag aagcccaagg    480

gtttggttgg agcacaagct gaacgtcggg aaagcctgaa ggcgacttct tttgagttca    540

aggggaagaa agagtctcgg cgggaaaatc aggtggacct tcctggacat atcctggacc    600

aggcttttct gctgaagcac cactgtgtga ggaagccatc agatctgtgc accattaatg    660

tgagtggcct gaagttctcc aaggccaagg aaaatgactt caagcatttt cattctgtga    720

tttatatcaa tgcctcagaa aacctgctgc ctctagaggc atttcacacg tttccagccc    780

taaaggaact ggatctcgca tttaatggca tcaaaactat ctacgtgaaa tatggagact    840

ttaagttatt agaattcttg gacctttcct tcaacagcct gactgtggag gccatctgtg    900

atttggggat tctgccacac ctccgtgtcc tgctcctcac aggcaatggc cttacctccc    960

tgccgcccaa tttggccgtc gcagaacagg aggcatctgt aacatcgctg acaagcaaga   1020

ggtacatcct gaggttccca gcgctggaga cactgatgct ggatgacaac agactctcca   1080

accccagttg ctttgccagc ctggctgggc tcaggagact gaagaagtta agcttggatg   1140

aaaacaggat tatcaggatc ccatacctac agcaagttca gctctatgac gagtcagtag   1200

actggaatgg aggcagggga agtccccata aagagcccca attcatgctg cagtccaagc   1260

caaggatgct tgaggactca gatgagcaac tggattatac tgtactgccc atgaaaaagg   1320

atgttgaccg gacaggggtc cctccactgc tgaagagctt cctccaggag cgactgggaa   1380

tccacttaat tcgaaggaag atagtaaagc ctaagcatca tgttttgatg tctcggaagg   1440

aatcatggaa ggtgaaaagc gaaatcccaa aggtgccgaa gcagcctctg gtgctccatc   1500

acccgcgcat gacgacaacc aagtctccct caaaggatat gctagagcca gaggcagagc   1560

tggctgaaga tctgcccact accaaaagca cttctgtgga gtcagagatg cccactgaga   1620

acctggaagg ccattccccg tcttgccgga ccttcgtgcc actgcctccc atctgctcca   1680

actccactgt gcatagtgaa gagaccctgt cccacctgag tgacacaact gtccgcctca   1740

gcccagagcg cccatcagat gaggactcca agagcacaga gtccatcttc ctgacccagg   1800

tgagtgaact gccttcctcc gtcatccata aggatgattt agagttaaag gagaaagacc   1860

aaaagaaacc accaacggca cccagagagg tgaaagggac tcggaggaaa ctcccaactg   1920

ccttccttcc cagcaagtac cacggctatg aagaactgct gacagccaag cctgatccag   1980

ccttcattga gccaaaggga atccagaaga atgcacaagc cctgcaacaa atgctgaagc   2040

acccactcct gtgccactcc tccaagccca agctggacac tcttcagaaa ccctatgttc   2100

acaaagagaa acgggcccag agaatcccga ttccaccccc aaagaagact agagcccaac   2160

ttctggatga catcttcatt cgcttgcggg atccccggaa cattacagag gctccactag   2220

gtgctgtcct gcaccagtgg acagaacggc ggctggtgaa ccacaagcag tacctggagg   2280

ccaagaggct gttgaaggag ttccaggcac gttaccggca gctggtgagt ggctctctgc   2340

gcacagtgtt cgggactacc ccgctcccca tggcctgccc agcgctgagt gagagccagc   2400

ccaagttcgg ccacttcctc gagttcatgg atgagttctg ccaggagccc acagccagtg   2460

actcacaagg ctagagctgt gcatgggggc tgtgtgcacc acccggcctg tgccccagct   2520

ctccccgagg gctctgtgcc ctggaccgca cctcaaggtt gaccagccgg ccacaggcct   2580

cagagctcag ctgggcccca cttgctggcc acaaggtggc atccccttgt caggatctcc   2640

cctccttggc ccaggcatga cctggtgcct ggcccagcgg caataaagag tgggtgcaca   2700

gggcaataga ctgggtgcca catgcattct ttcttggaac ccaggccaca gcagcattgt   2760

cacacttccc tctaaaaatg gttttccagt tcagatgcaa cagggataca tttgttctct   2820

gttgtatgag aaactgacac caaggggatc ttaacaaatt cctgaacaat ggctccaaaa   2880

aagggtattt ttaaaaacca gatcttgtga gtacagccct aatgtgcagg gacagtgtca   2940

tcctgtatat tcgttcttta ctcagactct ttcttggttc cttcattagg agcatgaatg   3000

gttgaatgtg aacatgacag taaattggag caaactgtaa actggacata acttatgcca   3060

aaagacgtag ttgtacacca tggaaacccc atccctgctc ctaatctcta ctgccattct   3120

gaatgccaaa gcaagacatc caacatgggg catctcccag agcacataca gcaccaaaaa   3180

tccacacaca gcctaagctt aacccatgtt tttgtctgag attgttcacc agagacaaga   3240

ctctgactat aaacagaaca tccactttca tgagtttcct ttactgtatt ctcaacttgg   3300

gccttgcttc aagcaggcaa acatacattg aagaatgcac tttggtactg tttaaataac   3360

aacacatcag cccacttgat tccatgccat gtccttgctg acagaaacat ccccaacagg   3420

gcatgccctg gtccaagtcc tctgtctttg tcaaaatgct cttctgatga gttggagagg   3480

aggcagccag cagtggcagt ccacaaggat ccaggtacct tctccaatcc taaagcagac   3540

agcaggttga ataaaaccaa tacacaacct attttctagg caggagggga aaaggccctt   3600

aggacaataa tatttgtaca aagagttgag agtaaacaaa cagtgtatca ggttcaaaaa   3660

aaaaaaaact attcgttggc atttaaattt ttttcccttg catagtatct attctctcac   3720

taggactttt aagtgctctg ctggaggctc agcgttggta ataccatgtt tgatgcaaac   3780

ttgaacccaa tgctctcatt ggtggcacag ctttggaggg tggtggcccc aagaaggggc   3840

aatctgcctg ctgctatatt aatctggaac cagggccaac agctactctt gaactatggt   3900

atttgaagag cgagttcatt gcctgtttta ccttaaatga caggaaagga agatgaacaa   3960

accttgcttt gccttggctt caaactagtt cttgatttaa gacaccagaa agggagagag   4020

ggagtctgct tagagtttga ggttgcctct cacaagatga cagttaaaag ttgccacctt   4080

acttaaaagg cattaaggag gcatttactc acaaaggaga gagagtaaat ttttttctta   4140

agaggaaaaa aatactgata atacatagaa caatctgcac atccagtctt ggcacttttt   4200

ccaatttgac tgatctctaa actggtgacc cttgcatata tcttagtctc ttttctacaa   4260

tcttcttcag aaagctacag cagctaacaa tcatgtataa agatgcattt cctagatcat   4320

cttcagaaga aaatctcttc agcactttcc ctagaatctg tctcctgacc accccgcccc   4380

agacctgctt tctcttttga gaattcataa ccaggtatgt ttagatacca gttcaaaaga   4440

ccactctatg ggttgatgag gaaaaggctg cctgaggaca atttaagacc ataatgagtt   4500

tccaattttt aaagaaaatt tggctagctg gcttttaatt cttaattaaa atcattaaat   4560

ttaattaaaa ttattccaat caaaatatat cactttccaa gattccacat tcatattact   4620

tacttatact atggagactt tctctacctg agcatgtatt caggggctat aggtacattt   4680

aactctaact aactgaaaaa aatcaggaag aaaaaactat taaaataaaa taacctccta   4740

aatcatttgg gggtatcccc atcattggtg cgtgtgtctg cgtgtgtcaa actttaatga   4800

ttatttattc agaccctgga aaaccacact ataaaatagg gcactggatc acaagttcgt   4860

ttggttaaaa aaaaaaaaaa aaaaaagtgg gggcgggggg cagagaagaa gtttaacttg   4920

gatgatttcc atgcccattc cagctgtaac attctatgac tgtgacccag cctttgttct   4980

cttttctcac tctcctacta gacatttcaa tgaaaagtta ggcaggaaaa aggaaaggaa   5040

tcccaagttg ctgccagctc tgatgagaga tcaggttggg ggagagatta ggtggttact   5100

gaattgaggt gtgggcctcc cctgaccatg tcagtgatcc acaacccacc tcacttcttg   5160

gggcttaagc taaaagcagc ttctgaagag atgttaatgt cctgtaatca ctagaggaga   5220

aaattcattc tccttccata acattactta gtaaaggaaa agcggtggtg caatcaaatt   5280

cacaaatacc aatggggtct ctaaaatgta gaatgcagct tgctgggtgc tggtcagttt   5340

tctaaatggg accagaaatg gctttcctaa gaccataaat gaactctcca gccacacata   5400

cattcaaatg cattccatta gacattgagc tcctcaagag caggaactgc tttatctcca   5460

cagtccagct cagggttggc tcaagtctga agctcagtaa atgtctgtca aatagaaaag   5520

aaaggatgag ccttcggtca tcagctacat gagtcaggca cggtggcagc ttcccatttt   5580

agtcagtttg ccagtttgta accagacagt aatcaattaa gagctttaat ctcttaagga   5640

catttttcct ttagggaaaa tgaacaaaaa ataaaacatt tattaccagt gctgcttcca   5700

agcaaaaatt taaaaattaa attaaaattt aaaaaataag tgaagccact taggagtttc   5760

cctggcaagc ctcacccaag aagacttaac cttttttaaa aagaggcaaa tagattaaag   5820

gggccagggg ctggatgcat aatcccctga tctgatacca acccaacagg cccagatgac   5880

ttcttccagc agatacaatc aatgggtcaa gaacattttc tcaaagtttc tttccctctc   5940

tatggaaaag agctgacagc ccccttctaa gggcaccaca tttcctggat ttcccctcag   6000

actgaccttc accctccccc ctaacttccc ctttaataat aaaaaaaccc agaatgcata   6060

tatacaagga acagagtaag acatgggtaa tttgtatggt gaactgggct tcaatgattt   6120

gtgaggaatt tgttttgtga aatcctgcac ctcttattct agctcacaaa cccttcccat   6180

cgttctgttt ccttccttgt ccttttctgt tcccccaaat aatacacatc aacatatcga   6240

cttttaacca acttcagaat catggaagga gagagggaga tttttcagaa agaaaagcat   6300

tcaggtttta gttattaagg atgggaagca tcttaaaatt cagataatac cttagtggtt   6360

tttccttcct ccaaagccaa cctgattaaa gatcaaccct c                       6401


<210>  2799
<211>  713
<212>  PRT
<213>  Homo sapiens

<400>  2799


Met Ala Phe Ser Gly Ile Tyr Lys Leu Asp Asp Gly Lys Pro Tyr Leu 
1               5                   10                  15      


Asn Asn Cys Phe Pro Ala Arg Asn Leu Leu Arg Val Pro Glu Glu Gly 
            20                  25                  30          


Gln Gly His Trp Leu Val Val Gln Lys Gly Asn Leu Lys Lys Lys Pro 
        35                  40                  45              


Lys Gly Leu Val Gly Ala Gln Ala Glu Arg Arg Glu Ser Leu Lys Ala 
    50                  55                  60                  


Thr Ser Phe Glu Phe Lys Gly Lys Lys Glu Ser Arg Arg Glu Asn Gln 
65                  70                  75                  80  


Val Asp Leu Pro Gly His Ile Leu Asp Gln Ala Phe Leu Leu Lys His 
                85                  90                  95      


His Cys Val Arg Lys Pro Ser Asp Leu Cys Thr Ile Asn Val Ser Gly 
            100                 105                 110         


Leu Lys Phe Ser Lys Ala Lys Glu Asn Asp Phe Lys His Phe His Ser 
        115                 120                 125             


Val Ile Tyr Ile Asn Ala Ser Glu Asn Leu Leu Pro Leu Glu Ala Phe 
    130                 135                 140                 


His Thr Phe Pro Ala Leu Lys Glu Leu Asp Leu Ala Phe Asn Gly Ile 
145                 150                 155                 160 


Lys Thr Ile Tyr Val Lys Tyr Gly Asp Phe Lys Leu Leu Glu Phe Leu 
                165                 170                 175     


Asp Leu Ser Phe Asn Ser Leu Thr Val Glu Ala Ile Cys Asp Leu Gly 
            180                 185                 190         


Ile Leu Pro His Leu Arg Val Leu Leu Leu Thr Gly Asn Gly Leu Thr 
        195                 200                 205             


Ser Leu Pro Pro Asn Leu Ala Val Ala Glu Gln Glu Ala Ser Val Thr 
    210                 215                 220                 


Ser Leu Thr Ser Lys Arg Tyr Ile Leu Arg Phe Pro Ala Leu Glu Thr 
225                 230                 235                 240 


Leu Met Leu Asp Asp Asn Arg Leu Ser Asn Pro Ser Cys Phe Ala Ser 
                245                 250                 255     


Leu Ala Gly Leu Arg Arg Leu Lys Lys Leu Ser Leu Asp Glu Asn Arg 
            260                 265                 270         


Ile Ile Arg Ile Pro Tyr Leu Gln Gln Val Gln Leu Tyr Asp Glu Ser 
        275                 280                 285             


Val Asp Trp Asn Gly Gly Arg Gly Ser Pro His Lys Glu Pro Gln Phe 
    290                 295                 300                 


Met Leu Gln Ser Lys Pro Arg Met Leu Glu Asp Ser Asp Glu Gln Leu 
305                 310                 315                 320 


Asp Tyr Thr Val Leu Pro Met Lys Lys Asp Val Asp Arg Thr Gly Val 
                325                 330                 335     


Pro Pro Leu Leu Lys Ser Phe Leu Gln Glu Arg Leu Gly Ile His Leu 
            340                 345                 350         


Ile Arg Arg Lys Ile Val Lys Pro Lys His His Val Leu Met Ser Arg 
        355                 360                 365             


Lys Glu Ser Trp Lys Val Lys Ser Glu Ile Pro Lys Val Pro Lys Gln 
    370                 375                 380                 


Pro Leu Val Leu His His Pro Arg Met Thr Thr Thr Lys Ser Pro Ser 
385                 390                 395                 400 


Lys Asp Met Leu Glu Pro Glu Ala Glu Leu Ala Glu Asp Leu Pro Thr 
                405                 410                 415     


Thr Lys Ser Thr Ser Val Glu Ser Glu Met Pro Thr Glu Asn Leu Glu 
            420                 425                 430         


Gly His Ser Pro Ser Cys Arg Thr Phe Val Pro Leu Pro Pro Ile Cys 
        435                 440                 445             


Ser Asn Ser Thr Val His Ser Glu Glu Thr Leu Ser His Leu Ser Asp 
    450                 455                 460                 


Thr Thr Val Arg Leu Ser Pro Glu Arg Pro Ser Asp Glu Asp Ser Lys 
465                 470                 475                 480 


Ser Thr Glu Ser Ile Phe Leu Thr Gln Val Ser Glu Leu Pro Ser Ser 
                485                 490                 495     


Val Ile His Lys Asp Asp Leu Glu Leu Lys Glu Lys Asp Gln Lys Lys 
            500                 505                 510         


Pro Pro Thr Ala Pro Arg Glu Val Lys Gly Thr Arg Arg Lys Leu Pro 
        515                 520                 525             


Thr Ala Phe Leu Pro Ser Lys Tyr His Gly Tyr Glu Glu Leu Leu Thr 
    530                 535                 540                 


Ala Lys Pro Asp Pro Ala Phe Ile Glu Pro Lys Gly Ile Gln Lys Asn 
545                 550                 555                 560 


Ala Gln Ala Leu Gln Gln Met Leu Lys His Pro Leu Leu Cys His Ser 
                565                 570                 575     


Ser Lys Pro Lys Leu Asp Thr Leu Gln Lys Pro Tyr Val His Lys Glu 
            580                 585                 590         


Lys Arg Ala Gln Arg Ile Pro Ile Pro Pro Pro Lys Lys Thr Arg Ala 
        595                 600                 605             


Gln Leu Leu Asp Asp Ile Phe Ile Arg Leu Arg Asp Pro Arg Asn Ile 
    610                 615                 620                 


Thr Glu Ala Pro Leu Gly Ala Val Leu His Gln Trp Thr Glu Arg Arg 
625                 630                 635                 640 


Leu Val Asn His Lys Gln Tyr Leu Glu Ala Lys Arg Leu Leu Lys Glu 
                645                 650                 655     


Phe Gln Ala Arg Tyr Arg Gln Leu Val Ser Gly Ser Leu Arg Thr Val 
            660                 665                 670         


Phe Gly Thr Thr Pro Leu Pro Met Ala Cys Pro Ala Leu Ser Glu Ser 
        675                 680                 685             


Gln Pro Lys Phe Gly His Phe Leu Glu Phe Met Asp Glu Phe Cys Gln 
    690                 695                 700                 


Glu Pro Thr Ala Ser Asp Ser Gln Gly 
705                 710             

<210>  2800
<211>  6495
<212>  DNA
<213>  Homo sapiens

<400>  2800
agtttgggtc ttgctggcgc gaggtagtca gaggacgtgg ccgcggggct tgctgggact     60

tgaggttaga cgtcccggcc gtcggttgcc gcctacactg tctgccgtcg cgtcgcagtt    120

actaaggcgt ggggaagata gcggcaggca ccgcagtgga gcggctccga gatccccggg    180

gggctcgcag gcgcgcatcc ctcctgactg ggacgtcgcc tccgcagacc cctcggaggc    240

tgaagcgacg ccggaggcag gcaaagaaac aagtgaagaa acaaaaaaaa aaggaagtta    300

aggggccatt cccaaagtca aagatcaagg agatggcctt ctcaggaatc tacaagctgg    360

atgatgggaa gccttacctg aacaactgct tcccagccag aaatctgctt cgcgtgccgg    420

aggaaggcca aggacactgg ttagtggttc agaaaggtaa cctcaagaag aagcccaagg    480

gtttggttgg agcacaagct gaacgtcggg aaagcctgaa ggcgacttct tttgagttca    540

aggggaagaa agagtctcgg cgggaaaatc aggtggacct tcctggacat atcctggacc    600

aggcttttct gctgaagcac cactgtgtga ggaagccatc agatctgtgc accattaatg    660

tgagtggcct gaagttctcc aaggccaagg aaaatgactt caagcatttt cattctgtga    720

tttatatcaa tgcctcagaa aacctgctgc ctctagaggc atttcacacg tttccagccc    780

taaaggaact ggatctcgca tttaatggca tcaaaactat ctacgtgaaa tatggagact    840

ttaagttatt agaattcttg gacctttcct tcaacagcct gactgtggag gccatctgtg    900

atttggggat tctgccacac ctccgtgtcc tgctcctcac aggcaatggc cttacctccc    960

tgccgcccaa tttggccgtc gcagaacagg aggcatctgt aacatcgctg acaagcaaga   1020

ggtacatcct gaggttccca gcgctggaga cactgatgct ggatgacaac agactctcca   1080

accccagttg ctttgccagc ctggctgggc tcaggagact gaagaagtta agcttggatg   1140

aaaacaggat tatcaggatc ccatacctac agcaagttca gctctatgac gagtcagtag   1200

actggaatgg aggcagggga agtccccata aagagcccca attcatgctg cagtccaagc   1260

caaggatgct tgaggactca gatgagcaac tggattatac tgtactgccc atgaaaaagg   1320

atgttgaccg gacagatcgc aaaagaggat gctgtcctac cagtagctct cttcccatct   1380

ctctgcgagt tcgtctttca taacaaccct ctggtggccc atacacgagg ggtccctcca   1440

ctgctgaaga gcttcctcca ggagcgactg ggaatccact taattcgaag gaagatagta   1500

aagcctaagc atcatgtttt gatgtctcgg aaggaatcat ggaaggtgaa aagcgaaatc   1560

ccaaaggtgc cgaagcagcc tctggtgctc catcacccgc gcatgacgac aaccaagtct   1620

ccctcaaagg atatgctaga gccagaggca gagctggctg aagatctgcc cactaccaaa   1680

agcacttctg tggagtcaga gatgcccact gagaacctgg aaggccattc cccgtcttgc   1740

cggaccttcg tgccactgcc tcccatctgc tccaactcca ctgtgcatag tgaagagacc   1800

ctgtcccacc tgagtgacac aactgtccgc ctcagcccag agcgcccatc agatgaggac   1860

tccaagagca cagagtccat cttcctgacc caggtgagtg aactgccttc ctccgtcatc   1920

cataaggatg atttagagtt aaaggagaaa gaccaaaaga aaccaccaac ggcacccaga   1980

gaggtgaaag ggactcggag gaaactccca actgccttcc ttcccagcaa gtaccacggc   2040

tatgaagaac tgctgacagc caagcctgat ccagccttca ttgagccaaa gggaatccag   2100

aagaatgcac aagccctgca acaaatgctg aagcacccac tcctgtgcca ctcctccaag   2160

cccaagctgg acactcttca gaaaccctat gttcacaaag agaaacgggc ccagagaatc   2220

ccgattccac ccccaaagaa gactagagcc caacttctgg atgacatctt cattcgcttg   2280

cgggatcccc ggaacattac agaggctcca ctaggtgctg tcctgcacca gtggacagaa   2340

cggcggctgg tgaaccacaa gcagtacctg gaggccaaga ggctgttgaa ggagttccag   2400

gcacgttacc ggcagctggt gagtggctct ctgcgcacag tgttcgggac taccccgctc   2460

cccatggcct gcccagcgct gagtgagagc cagcccaagt tcggccactt cctcgagttc   2520

atggatgagt tctgccagga gcccacagcc agtgactcac aaggctagag ctgtgcatgg   2580

gggctgtgtg caccacccgg cctgtgcccc agctctcccc gagggctctg tgccctggac   2640

cgcacctcaa ggttgaccag ccggccacag gcctcagagc tcagctgggc cccacttgct   2700

ggccacaagg tggcatcccc ttgtcaggat ctcccctcct tggcccaggc atgacctggt   2760

gcctggccca gcggcaataa agagtgggtg cacagggcaa tagactgggt gccacatgca   2820

ttctttcttg gaacccaggc cacagcagca ttgtcacact tccctctaaa aatggttttc   2880

cagttcagat gcaacaggga tacatttgtt ctctgttgta tgagaaactg acaccaaggg   2940

gatcttaaca aattcctgaa caatggctcc aaaaaagggt atttttaaaa accagatctt   3000

gtgagtacag ccctaatgtg cagggacagt gtcatcctgt atattcgttc tttactcaga   3060

ctctttcttg gttccttcat taggagcatg aatggttgaa tgtgaacatg acagtaaatt   3120

ggagcaaact gtaaactgga cataacttat gccaaaagac gtagttgtac accatggaaa   3180

ccccatccct gctcctaatc tctactgcca ttctgaatgc caaagcaaga catccaacat   3240

ggggcatctc ccagagcaca tacagcacca aaaatccaca cacagcctaa gcttaaccca   3300

tgtttttgtc tgagattgtt caccagagac aagactctga ctataaacag aacatccact   3360

ttcatgagtt tcctttactg tattctcaac ttgggccttg cttcaagcag gcaaacatac   3420

attgaagaat gcactttggt actgtttaaa taacaacaca tcagcccact tgattccatg   3480

ccatgtcctt gctgacagaa acatccccaa cagggcatgc cctggtccaa gtcctctgtc   3540

tttgtcaaaa tgctcttctg atgagttgga gaggaggcag ccagcagtgg cagtccacaa   3600

ggatccaggt accttctcca atcctaaagc agacagcagg ttgaataaaa ccaatacaca   3660

acctattttc taggcaggag gggaaaaggc ccttaggaca ataatatttg tacaaagagt   3720

tgagagtaaa caaacagtgt atcaggttca aaaaaaaaaa aactattcgt tggcatttaa   3780

atttttttcc cttgcatagt atctattctc tcactaggac ttttaagtgc tctgctggag   3840

gctcagcgtt ggtaatacca tgtttgatgc aaacttgaac ccaatgctct cattggtggc   3900

acagctttgg agggtggtgg ccccaagaag gggcaatctg cctgctgcta tattaatctg   3960

gaaccagggc caacagctac tcttgaacta tggtatttga agagcgagtt cattgcctgt   4020

tttaccttaa atgacaggaa aggaagatga acaaaccttg ctttgccttg gcttcaaact   4080

agttcttgat ttaagacacc agaaagggag agagggagtc tgcttagagt ttgaggttgc   4140

ctctcacaag atgacagtta aaagttgcca ccttacttaa aaggcattaa ggaggcattt   4200

actcacaaag gagagagagt aaattttttt cttaagagga aaaaaatact gataatacat   4260

agaacaatct gcacatccag tcttggcact ttttccaatt tgactgatct ctaaactggt   4320

gacccttgca tatatcttag tctcttttct acaatcttct tcagaaagct acagcagcta   4380

acaatcatgt ataaagatgc atttcctaga tcatcttcag aagaaaatct cttcagcact   4440

ttccctagaa tctgtctcct gaccaccccg ccccagacct gctttctctt ttgagaattc   4500

ataaccaggt atgtttagat accagttcaa aagaccactc tatgggttga tgaggaaaag   4560

gctgcctgag gacaatttaa gaccataatg agtttccaat ttttaaagaa aatttggcta   4620

gctggctttt aattcttaat taaaatcatt aaatttaatt aaaattattc caatcaaaat   4680

atatcacttt ccaagattcc acattcatat tacttactta tactatggag actttctcta   4740

cctgagcatg tattcagggg ctataggtac atttaactct aactaactga aaaaaatcag   4800

gaagaaaaaa ctattaaaat aaaataacct cctaaatcat ttgggggtat ccccatcatt   4860

ggtgcgtgtg tctgcgtgtg tcaaacttta atgattattt attcagaccc tggaaaacca   4920

cactataaaa tagggcactg gatcacaagt tcgtttggtt aaaaaaaaaa aaaaaaaaaa   4980

gtgggggcgg ggggcagaga agaagtttaa cttggatgat ttccatgccc attccagctg   5040

taacattcta tgactgtgac ccagcctttg ttctcttttc tcactctcct actagacatt   5100

tcaatgaaaa gttaggcagg aaaaaggaaa ggaatcccaa gttgctgcca gctctgatga   5160

gagatcaggt tgggggagag attaggtggt tactgaattg aggtgtgggc ctcccctgac   5220

catgtcagtg atccacaacc cacctcactt cttggggctt aagctaaaag cagcttctga   5280

agagatgtta atgtcctgta atcactagag gagaaaattc attctccttc cataacatta   5340

cttagtaaag gaaaagcggt ggtgcaatca aattcacaaa taccaatggg gtctctaaaa   5400

tgtagaatgc agcttgctgg gtgctggtca gttttctaaa tgggaccaga aatggctttc   5460

ctaagaccat aaatgaactc tccagccaca catacattca aatgcattcc attagacatt   5520

gagctcctca agagcaggaa ctgctttatc tccacagtcc agctcagggt tggctcaagt   5580

ctgaagctca gtaaatgtct gtcaaataga aaagaaagga tgagccttcg gtcatcagct   5640

acatgagtca ggcacggtgg cagcttccca ttttagtcag tttgccagtt tgtaaccaga   5700

cagtaatcaa ttaagagctt taatctctta aggacatttt tcctttaggg aaaatgaaca   5760

aaaaataaaa catttattac cagtgctgct tccaagcaaa aatttaaaaa ttaaattaaa   5820

atttaaaaaa taagtgaagc cacttaggag tttccctggc aagcctcacc caagaagact   5880

taaccttttt taaaaagagg caaatagatt aaaggggcca ggggctggat gcataatccc   5940

ctgatctgat accaacccaa caggcccaga tgacttcttc cagcagatac aatcaatggg   6000

tcaagaacat tttctcaaag tttctttccc tctctatgga aaagagctga cagccccctt   6060

ctaagggcac cacatttcct ggatttcccc tcagactgac cttcaccctc ccccctaact   6120

tcccctttaa taataaaaaa acccagaatg catatataca aggaacagag taagacatgg   6180

gtaatttgta tggtgaactg ggcttcaatg atttgtgagg aatttgtttt gtgaaatcct   6240

gcacctctta ttctagctca caaacccttc ccatcgttct gtttccttcc ttgtcctttt   6300

ctgttccccc aaataataca catcaacata tcgactttta accaacttca gaatcatgga   6360

aggagagagg gagatttttc agaaagaaaa gcattcaggt tttagttatt aaggatggga   6420

agcatcttaa aattcagata ataccttagt ggtttttcct tcctccaaag ccaacctgat   6480

taaagatcaa ccctc                                                    6495


<210>  2801
<211>  415
<212>  PRT
<213>  Homo sapiens

<400>  2801


Met Leu Thr Gly Gln Ile Ala Lys Glu Asp Ala Val Leu Pro Val Ala 
1               5                   10                  15      


Leu Phe Pro Ser Leu Cys Glu Phe Val Phe His Asn Asn Pro Leu Val 
            20                  25                  30          


Ala His Thr Arg Gly Val Pro Pro Leu Leu Lys Ser Phe Leu Gln Glu 
        35                  40                  45              


Arg Leu Gly Ile His Leu Ile Arg Arg Lys Ile Val Lys Pro Lys His 
    50                  55                  60                  


His Val Leu Met Ser Arg Lys Glu Ser Trp Lys Val Lys Ser Glu Ile 
65                  70                  75                  80  


Pro Lys Val Pro Lys Gln Pro Leu Val Leu His His Pro Arg Met Thr 
                85                  90                  95      


Thr Thr Lys Ser Pro Ser Lys Asp Met Leu Glu Pro Glu Ala Glu Leu 
            100                 105                 110         


Ala Glu Asp Leu Pro Thr Thr Lys Ser Thr Ser Val Glu Ser Glu Met 
        115                 120                 125             


Pro Thr Glu Asn Leu Glu Gly His Ser Pro Ser Cys Arg Thr Phe Val 
    130                 135                 140                 


Pro Leu Pro Pro Ile Cys Ser Asn Ser Thr Val His Ser Glu Glu Thr 
145                 150                 155                 160 


Leu Ser His Leu Ser Asp Thr Thr Val Arg Leu Ser Pro Glu Arg Pro 
                165                 170                 175     


Ser Asp Glu Asp Ser Lys Ser Thr Glu Ser Ile Phe Leu Thr Gln Val 
            180                 185                 190         


Ser Glu Leu Pro Ser Ser Val Ile His Lys Asp Asp Leu Glu Leu Lys 
        195                 200                 205             


Glu Lys Asp Gln Lys Lys Pro Pro Thr Ala Pro Arg Glu Val Lys Gly 
    210                 215                 220                 


Thr Arg Arg Lys Leu Pro Thr Ala Phe Leu Pro Ser Lys Tyr His Gly 
225                 230                 235                 240 


Tyr Glu Glu Leu Leu Thr Ala Lys Pro Asp Pro Ala Phe Ile Glu Pro 
                245                 250                 255     


Lys Gly Ile Gln Lys Asn Ala Gln Ala Leu Gln Gln Met Leu Lys His 
            260                 265                 270         


Pro Leu Leu Cys His Ser Ser Lys Pro Lys Leu Asp Thr Leu Gln Lys 
        275                 280                 285             


Pro Tyr Val His Lys Glu Lys Arg Ala Gln Arg Ile Pro Ile Pro Pro 
    290                 295                 300                 


Pro Lys Lys Thr Arg Ala Gln Leu Leu Asp Asp Ile Phe Ile Arg Leu 
305                 310                 315                 320 


Arg Asp Pro Arg Asn Ile Thr Glu Ala Pro Leu Gly Ala Val Leu His 
                325                 330                 335     


Gln Trp Thr Glu Arg Arg Leu Val Asn His Lys Gln Tyr Leu Glu Ala 
            340                 345                 350         


Lys Arg Leu Leu Lys Glu Phe Gln Ala Arg Tyr Arg Gln Leu Val Ser 
        355                 360                 365             


Gly Ser Leu Arg Thr Val Phe Gly Thr Thr Pro Leu Pro Met Ala Cys 
    370                 375                 380                 


Pro Ala Leu Ser Glu Ser Gln Pro Lys Phe Gly His Phe Leu Glu Phe 
385                 390                 395                 400 


Met Asp Glu Phe Cys Gln Glu Pro Thr Ala Ser Asp Ser Gln Gly 
                405                 410                 415 

<210>  2802
<211>  5985
<212>  DNA
<213>  Homo sapiens

<400>  2802
aatcgggatc cgtagtttgg gtcttgctgg cgcgaggtag tcagaggacg tggccgcggg     60

gcttgctggg acttgaggtt agacgtcccg gccgtcggtt gccgcctaca ctgtctgccg    120

tcgcgtcgca gttactaagg cgtggggaag atagcggcag gcaccgcagt ggagcggctc    180

cgagatcccc ggggggctcg caggcgcgca tccctcctga ctgggacgtc gcctccgcag    240

acccctcgga ggctgaagcg acgccggagg caggccaagg acactggtta gtggttcaga    300

aaggtaacct caagaagaag cccaagggtt tggttggagc acaagctgaa cgtcgggaaa    360

gcctgaaggc gacttctttt gagttcaagg ggaagaaaga gtctcggcgg gaaaatcagg    420

tggaccttcc tggacatatc ctggaccagg cttttctgct gaagcaccac tgtgtgagga    480

agccatcaga tctgtgcacc attaatgtga gtggcctgaa gttctccaag gccaaggaaa    540

atgacttcaa gcattttcat tctgtgattt atatcaatgc ctcagaaaac ctgctgcctc    600

tagaggcatt tcacacgttt ccagccctaa aggaactgga tctcgcattt aatggcatca    660

aaactatcta cgtgaaatat ggagacttta agttattaga attcttggac ctttccttca    720

acagcctgac tgtggaggcc atctgtgatt tggggattct gccacacctc cgtgtcctgc    780

tcctcacagg caatggcctt acctccctgc cgcccaattt ggccgtcgca gaacaggagg    840

catctgtaac atcgctgaca agcaagaggt acatcctgag gttcccagcg ctggagacac    900

tgatgctgga tgacaacaga ctctccaacc ccagttgctt tgccagcctg gctgggctca    960

ggagactgaa gaagttaagc ttggatgaaa acaggattat caggatccca tacctacagc   1020

aagttcagct ctatgacgag tcagtagact ggaatggagg caggggaagt ccccataaag   1080

agccccaatt catgctgcag tccaagccaa ggatgcttga ggactcagat gagcaactgg   1140

attatactgt actgcccatg aaaaaggatg ttgaccggac agatcgcaaa agaggatgct   1200

gtcctaccag tagctctctt cccatctctc tgcgagttcg tctttcataa caaccctctg   1260

gtggcccata cacgaggggt ccctccactg ctgaagagct tcctccagga gcgactggga   1320

atccacttaa ttcgaaggaa gatagtaaag cctaagcatc atgttttgat gtctcggaag   1380

gaatcatgga aggtgaaaag cgaaatccca aaggtgccga agcagcctct ggtgctccat   1440

cacccgcgca tgacgacaac caagtctccc tcaaaggata tgctagagcc agaggcagag   1500

ctggctgaag atctgcccac taccaaaagc acttctgtgg agtcagagat gcccactgag   1560

aacctggaag gccattcccc gtcttgccgg accttcgtgc cactgcctcc catctgctcc   1620

aactccactg tgcatagtga agagaccctg tcccacctga gtgacacaac tgtccgcctc   1680

agcccagagc gcccatcaga tgaggactcc aagagcacag agtccatctt cctgacccag   1740

gtgagtgaac tgccttcctc cgtcatccat aaggatgatt tagagttaaa ggagaaagac   1800

caaaagaaac caccaacggc acccagagag gtgaaaggga ctcggaggaa actcccaact   1860

gccttccttc ccagcaagta ccacggctat gaagaactgc tgacagccaa gcctgatcca   1920

gccttcattg agccaaaggg aatccagaag aatgcacaag ccctgcaaca aatgctgaag   1980

cacccactcc tgtgccactc ctccaagccc aagctggaca ctcttcagaa accctatgtt   2040

cacaaagaga aacgggccca gagaatcccg attccacccc caaagaagac tagagcccaa   2100

cttctggatg acatcttcat tcgcttgcgg gatccccgga acattacaga ggctccacta   2160

ggtacggctc tgccacagct gccaggatcc cagatccagt tcacgcctgc tggctaaagg   2220

caaagaaagg gcttgtgtca gtgcaggaaa ggcccttaga gagcaactgc ctacatcagt   2280

ctctacatgt agatggacaa aaggagagcc agcgtgaggc agggagttgc ctaaaatcac   2340

acagcatgtt aaggtcctga accagggctt aagatagagt caatgcatag gggcagtagg   2400

aagtcagtga cttcccaagc tggaaaggcc atttttagcc ccttagcatc ctcctgccac   2460

accatcccat tttccaaggg tctctggacc caatcctctt gcttctggct aggtgagaac   2520

caggatgagc ttggtgcctc tcctggcttc ttttcctgca ggtgctgtcc tgcaccagtg   2580

gacagaacgg cggctggtga accacaagca gtacctggag gccaagaggc tgttgaagga   2640

gttccaggca cgttaccggc agctggtgag tggctctctg cgcacagtgt tcgggactac   2700

cccgctcccc atggcctgcc cagcgctgag tgagagccag cccaagttcg gccacttcct   2760

cgagttcatg gatgagttct gccaggagcc cacagccagt gactcacaag gctagagctg   2820

tgcatggggg ctgtgtgcac cacccggcct gtgccccagc tctccccgag ggctctgtgc   2880

cctggaccgc acctcaaggt tgaccagccg gccacaggcc tcagagctca gctgggcccc   2940

acttgctggc cacaaggtgg catccccttg tcaggatctc ccctccttgg cccaggcatg   3000

acctggtgcc tggcccagcg gcaataaaga gtgggtgcac agggcaatag actgggtgcc   3060

acatgcattc tttcttggaa cccaggccac agcagcattg tcacacttcc ctctaaaaat   3120

ggttttccag ttcagatgca acagggatac atttgttctc tgttgtatga gaaactgaca   3180

ccaaggggat cttaacaaat tcctgaacaa tggctccaaa aaagggtatt tttaaaaacc   3240

agatcttgtg agtacagccc taatgtgcag ggacagtgtc atcctgtata ttcgttcttt   3300

actcagactc tttcttggtt ccttcattag gagcatgaat ggttgaatgt gaacatgaca   3360

gtaaattgga gcaaactgta aactggacat aacttatgcc aaaagacgta gttgtacacc   3420

atggaaaccc catccctgct cctaatctct actgccattc tgaatgccaa agcaagacat   3480

ccaacatggg gcatctccca gagcacatac agcaccaaaa atccacacac agcctaagct   3540

taacccatgt ttttgtctga gattgttcac cagagacaag actctgacta taaacagaac   3600

atccactttc atgagtttcc tttactgtat tctcaacttg ggccttgctt caagcaggca   3660

aacatacatt gaagaatgca ctttggtact gtttaaataa caacacatca gcccacttga   3720

ttccatgcca tgtccttgct gacagaaaca tccccaacag ggcatgccct ggtccaagtc   3780

ctctgtcttt gtcaaaatgc tcttctgatg agttggagag gaggcagcca gcagtggcag   3840

tccacaagga tccaggtacc ttctccaatc ctaaagcaga cagcaggttg aataaaacca   3900

atacacaacc tattttctag gcaggagggg aaaaggccct taggacaata atatttgtac   3960

aaagagttga gagtaaacaa acagtgtatc aggttcaaaa aaaaaaaaac tattcgttgg   4020

catttaaatt tttttccctt gcatagtatc tattctctca ctaggacttt taagtgctct   4080

gctggaggct cagcgttggt aataccatgt ttgatgcaaa cttgaaccca atgctctcat   4140

tggtggcaca gctttggagg gtggtggccc caagaagggg caatctgcct gctgctatat   4200

taatctggaa ccagggccaa cagctactct tgaactatgg tatttgaaga gcgagttcat   4260

tgcctgtttt accttaaatg acaggaaagg aagatgaaca aaccttgctt tgccttggct   4320

tcaaactagt tcttgattta agacaccaga aagggagaga gggagtctgc ttagagtttg   4380

aggttgcctc tcacaagatg acagttaaaa gttgccacct tacttaaaag gcattaagga   4440

ggcatttact cacaaaggag agagagtaaa tttttttctt aagaggaaaa aaatactgat   4500

aatacataga acaatctgca catccagtct tggcactttt tccaatttga ctgatctcta   4560

aactggtgac ccttgcatat atcttagtct cttttctaca atcttcttca gaaagctaca   4620

gcagctaaca atcatgtata aagatgcatt tcctagatca tcttcagaag aaaatctctt   4680

cagcactttc cctagaatct gtctcctgac caccccgccc cagacctgct ttctcttttg   4740

agaattcata accaggtatg tttagatacc agttcaaaag accactctat gggttgatga   4800

ggaaaaggct gcctgaggac aatttaagac cataatgagt ttccaatttt taaagaaaat   4860

ttggctagct ggcttttaat tcttaattaa aatcattaaa tttaattaaa attattccaa   4920

tcaaaatata tcactttcca agattccaca ttcatattac ttacttatac tatggagact   4980

ttctctacct gagcatgtat tcaggggcta taggtacatt taactctaac taactgaaaa   5040

aaatcaggaa gaaaaaacta ttaaaataaa ataacctcct aaatcatttg ggggtatccc   5100

catcattggt gcgtgtgtct gcgtgtgtca aactttaatg attatttatt cagaccctgg   5160

aaaaccacac tataaaatag ggcactggat cacaagttcg tttggttaaa aaaaaaaaaa   5220

aaaaaaagtg ggggcggggg gcagagaaga agtttaactt ggatgatttc catgcccatt   5280

ccagctgtaa cattctatga ctgtgaccca gcctttgttc tcttttctca ctctcctact   5340

agacatttca atgaaaagtt aggcaggaaa aaggaaagga atcccaagtt gctgccagct   5400

ctgatgagag atcaggttgg gggagagatt aggtggttac tgaattgagg tgtgggcctc   5460

ccctgaccat gtcagtgatc cacaacccac ctcacttctt ggggcttaag ctaaaagcag   5520

cttctgaaga gatgttaatg tcctgtaatc actagaggag aaaattcatt ctccttccat   5580

aacattactt agtaaaggaa aagcggtggt gcaatcaaat tcacaaatac caatggggtc   5640

tctaaaatgt agaatgcagc ttgctgggtg ctggtcagtt ttctaaatgg gaccagaaat   5700

ggctttccta agaccataaa tgaactctcc agccacacat acattcaaat gcattccatt   5760

agacattgag ctcctcaaga gcaggaactg ctttatctcc acagtccagc tcagggttgg   5820

ctcaagtctg aagctcagta aatgtctgtc aaatagaaaa gaaaggatga gccttcggtc   5880

atcagctaca tgagtcaggc acggtggcag cttcccattt tagtcagttt gccagtttgt   5940

aaccagacag taatcaatta agagctttaa tctcttaagg acatt                   5985


<210>  2803
<211>  349
<212>  PRT
<213>  Homo sapiens

<400>  2803


Met Leu Thr Gly Gln Ile Ala Lys Glu Asp Ala Val Leu Pro Val Ala 
1               5                   10                  15      


Leu Phe Pro Ser Leu Cys Glu Phe Val Phe His Asn Asn Pro Leu Val 
            20                  25                  30          


Ala His Thr Arg Gly Val Pro Pro Leu Leu Lys Ser Phe Leu Gln Glu 
        35                  40                  45              


Arg Leu Gly Ile His Leu Ile Arg Arg Lys Ile Val Lys Pro Lys His 
    50                  55                  60                  


His Val Leu Met Ser Arg Lys Glu Ser Trp Lys Val Lys Ser Glu Ile 
65                  70                  75                  80  


Pro Lys Val Pro Lys Gln Pro Leu Val Leu His His Pro Arg Met Thr 
                85                  90                  95      


Thr Thr Lys Ser Pro Ser Lys Asp Met Leu Glu Pro Glu Ala Glu Leu 
            100                 105                 110         


Ala Glu Asp Leu Pro Thr Thr Lys Ser Thr Ser Val Glu Ser Glu Met 
        115                 120                 125             


Pro Thr Glu Asn Leu Glu Gly His Ser Pro Ser Cys Arg Thr Phe Val 
    130                 135                 140                 


Pro Leu Pro Pro Ile Cys Ser Asn Ser Thr Val His Ser Glu Glu Thr 
145                 150                 155                 160 


Leu Ser His Leu Ser Asp Thr Thr Val Arg Leu Ser Pro Glu Arg Pro 
                165                 170                 175     


Ser Asp Glu Asp Ser Lys Ser Thr Glu Ser Ile Phe Leu Thr Gln Val 
            180                 185                 190         


Ser Glu Leu Pro Ser Ser Val Ile His Lys Asp Asp Leu Glu Leu Lys 
        195                 200                 205             


Glu Lys Asp Gln Lys Lys Pro Pro Thr Ala Pro Arg Glu Val Lys Gly 
    210                 215                 220                 


Thr Arg Arg Lys Leu Pro Thr Ala Phe Leu Pro Ser Lys Tyr His Gly 
225                 230                 235                 240 


Tyr Glu Glu Leu Leu Thr Ala Lys Pro Asp Pro Ala Phe Ile Glu Pro 
                245                 250                 255     


Lys Gly Ile Gln Lys Asn Ala Gln Ala Leu Gln Gln Met Leu Lys His 
            260                 265                 270         


Pro Leu Leu Cys His Ser Ser Lys Pro Lys Leu Asp Thr Leu Gln Lys 
        275                 280                 285             


Pro Tyr Val His Lys Glu Lys Arg Ala Gln Arg Ile Pro Ile Pro Pro 
    290                 295                 300                 


Pro Lys Lys Thr Arg Ala Gln Leu Leu Asp Asp Ile Phe Ile Arg Leu 
305                 310                 315                 320 


Arg Asp Pro Arg Asn Ile Thr Glu Ala Pro Leu Gly Thr Ala Leu Pro 
                325                 330                 335     


Gln Leu Pro Gly Ser Gln Ile Gln Phe Thr Pro Ala Gly 
            340                 345                 

<210>  2804
<211>  5180
<212>  DNA
<213>  Homo sapiens

<400>  2804
ttacagcttt gttagtagct ttgcttccac aacaatctgc ttttgtttca ggagtgaaac     60

ttttgaattt ctcagaggat actaattatt ctattttgaa gtttttataa cttttgttaa    120

ataaactgtt tttattcagg tgataattct tccctttttt atattgttaa ttttcctcaa    180

atagtaggag attcttgatt attcagtctt tttgtgtaac aatcctcaat cagaagctta    240

aaatgcagta attcctgtga ttgtggggag agcaggatgc gcgttcagac agcgtgccca    300

tctttctaga ggtgctgttg ttttctaggg ttcattgctt agcactcaca cttgcaacca    360

tggcccatcc cccagggaat tcctactttg ttcattgcac aaagctttcc caaactccct    420

tgcagaccct catcacagga gaagttattt atgccatgtt gttccatctc ctattactgt    480

tttcttcatt ttcatgtgac ttgtctcatt ataatatcat taacatgtag aaggtgtcgg    540

ttaactaggg taaaggtgag caatgtctgc acaggatcta gtcccagcag atgctatgct    600

gtgttaggtt gaactcagct gttagactca tctcattctg acggtcccaa gaatgaaatc    660

actctgcagc ctcctcctta tgactgtgtg ctggttgttc ttggtatctc tcctgaattc    720

actggctcaa cacattctgt ttctactaat ataagaaata tttccaaatc ctctgacaga    780

atgtcttcta tatacatttt tctcttctaa gacagttggt tagctttctg ctcagtatgg    840

actccccagt aattctgagg ctcgaaagtg cttatgtgct ttaaagtcag attgaaggtc    900

agtcagtgtg gctgaaatac agtgaatgag ggagagtatc atgaaatgag actgaagaag    960

taggcagggg cccaatcatg caggacatca gaggactaga taagcagttt gtattttatc   1020

ctaagtgcaa agggacttat tacctgatgc atgtcacagc cagctcctct tcctagttag   1080

cactggggct gaggaccaat gagaactccc tctaggaggt gccctgctgc acacagtgga   1140

tggcagacct atatcctggg tgctctaggc atcaatcagc ggtctcacca accttcattc   1200

tgtttctctt ctgtttcaga ggttgtgttt tcatcttacc ctggattttc aacctcagag   1260

gtgaaaagcg aaatcccaaa ggtgccgaag cagcctctgg tgctccatca cccgcgcatg   1320

acgacaacca agtctccctc aaaggatatg ctagagccag aggcagagct ggctgaagat   1380

ctgcccacta ccaaaagcac ttctgtggag tcagagatgc ccactgagaa cctggaaggc   1440

cattccccgt cttgccggac cttcgtgcca ctgcctccca tctgctccaa ctccactgtg   1500

catagtgaag agaccctgtc ccacctgagt gacacaactg tccgcctcag cccagagcgc   1560

ccatcagatg aggactccaa gagcacagag tccatcttcc tgacccaggt gagtgaactg   1620

ccttcctccg tcatccataa ggatgattta gagttaaagg agaaagacca aaagaaacca   1680

ccaacggcac ccagagaggt gaaagggact cggaggaaac tcccaactgc cttccttccc   1740

agcaagtacc acggctatga agaactgctg acagccaagc ctgatccagc cttcattgag   1800

ccaaagggaa tccagaagaa tgcacaagcc ctgcaacaaa tgctgaagca cccactcctg   1860

tgccactcct ccaagcccaa gctggacact cttcagaaac cctatgttca caaagagaaa   1920

cgggtaaaca tccagctcac tgaatgtgta aatggcccct gagtaccgcc cacaattaca   1980

gatgtggctg tcaccttggg accctctgag ggccatgctt tcccagcacc cccagatgcc   2040

ccccagcctg ttgctgtgac tgtatgaagt taggccaggg aagtctgtgc ataaacctgg   2100

gataacaccc tcctccatga ccttctgcca ggcccagaga atcccgattc cacccccaaa   2160

gaagactaga gcccaacttc tggatgacat cttcattcgc ttgcgggatc cccggaacat   2220

tacagaggct ccactaggta cggctctgcc acagctgcca ggatcccaga tccagttcac   2280

gcctgctggc taaaggcaaa gaaagggctt gtgtcagtgc aggaaaggcc cttagagagc   2340

aactgcctac atcagtctct acatgtagat ggacaaaagg agagccagcg tgaggcaggg   2400

agttgcctaa aatcacacag catgttaagg tcctgaacca gggcttaaga tagagtcaat   2460

gcataggggc agtaggaagt cagtgacttc ccaagctgga aaggccattt ttagcccctt   2520

agcatcctcc tgccacacca tcccattttc caagggtctc tggacccaat cctcttgctt   2580

ctggctaggt gagaaccagg atgagcttgg tgcctctcct ggcttctttt cctgcaggtg   2640

ctgtcctgca ccagtggaca gaacggcggc tggtgaacca caagcagtac ctggaggcca   2700

agaggctgtt gaaggagttc caggcacgtt accggcagct ggtgagtggc tctctgcgca   2760

cagtgttcgg gactaccccg ctccccatgg cctgcccagc gctgagtgag agccagccca   2820

agttcggcca cttcctcgag ttcatggatg agttctgcca ggagcccaca gccagtgact   2880

cacaaggcta gagctgtgca tgggggctgt gtgcaccacc cggcctgtgc cccagctctc   2940

cccgagggct ctgtgccctg gaccgcacct caaggttgac cagccggcca caggcctcag   3000

agctcagctg ggccccactt gctggccaca aggtggcatc cccttgtcag gatctcccct   3060

ccttggccca ggcatgacct ggtgcctggc ccagcggcaa taaagagtgg gtgcacaggg   3120

caatagactg ggtgccacat gcattctttc ttggaaccca ggccacagca gcattgtcac   3180

acttccctct aaaaatggtt ttccagttca gatgcaacag ggatacattt gttctctgtt   3240

gtatgagaaa ctgacaccaa ggggatctta acaaattcct gaacaatggc tccaaaaaag   3300

ggtattttta aaaaccagat cttgtgagta cagccctaat gtgcagggac agtgtcatcc   3360

tgtatattcg ttctttactc agactctttc ttggttcctt cattaggagc atgaatggtt   3420

gaatgtgaac atgacagtaa attggagcaa actgtaaact ggacataact tatgccaaaa   3480

gacgtagttg tacaccatgg aaaccccatc cctgctccta atctctactg ccattctgaa   3540

tgccaaagca agacatccaa catggggcat ctcccagagc acatacagca ccaaaaatcc   3600

acacacagcc taagcttaac ccatgttttt gtctgagatt gttcaccaga gacaagactc   3660

tgactataaa cagaacatcc actttcatga gtttccttta ctgtattctc aacttgggcc   3720

ttgcttcaag caggcaaaca tacattgaag aatgcacttt ggtactgttt aaataacaac   3780

acatcagccc acttgattcc atgccatgtc cttgctgaca gaaacatccc caacagggca   3840

tgccctggtc caagtcctct gtctttgtca aaatgctctt ctgatgagtt ggagaggagg   3900

cagccagcag tggcagtcca caaggatcca ggtaccttct ccaatcctaa agcagacagc   3960

aggttgaata aaaccaatac acaacctatt ttctaggcag gaggggaaaa ggcccttagg   4020

acaataatat ttgtacaaag agttgagagt aaacaaacag tgtatcaggt tcaaaaaaaa   4080

aaaaactatt cgttggcatt taaatttttt tcccttgcat agtatctatt ctctcactag   4140

gacttttaag tgctctgctg gaggctcagc gttggtaata ccatgtttga tgcaaacttg   4200

aacccaatgc tctcattggt ggcacagctt tggagggtgg tggccccaag aaggggcaat   4260

ctgcctgctg ctatattaat ctggaaccag ggccaacagc tactcttgaa ctatggtatt   4320

tgaagagcga gttcattgcc tgttttacct taaatgacag gaaaggaaga tgaacaaacc   4380

ttgctttgcc ttggcttcaa actagttctt gatttaagac accagaaagg gagagaggga   4440

gtctgcttag agtttgaggt tgcctctcac aagatgacag ttaaaagttg ccaccttact   4500

taaaaggcat taaggaggca tttactcaca aaggagagag agtaaatttt tttcttaaga   4560

ggaaaaaaat actgataata catagaacaa tctgcacatc cagtcttggc actttttcca   4620

atttgactga tctctaaact ggtgaccctt gcatatatct tagtctcttt tctacaatct   4680

tcttcagaaa gctacagcag ctaacaatca tgtataaaga tgcatttcct agatcatctt   4740

cagaagaaaa tctcttcagc actttcccta gaatctgtct cctgaccacc ccgccccaga   4800

cctgctttct cttttgagaa ttcataacca ggtatgttta gataccagtt caaaagacca   4860

ctctatgggt tgatgaggaa aaggctgcct gaggacaatt taagaccata atgagtttcc   4920

aatttttaaa gaaaatttgg ctagctggct tttaattctt aattaaaatc attaaattta   4980

attaaaatta ttccaatcaa aatatatcac tttccaagat tccacattca tattacttac   5040

ttatactatg gagactttct ctacctgagc atgtattcag gggctatagg tacatttaac   5100

tctaactaac tgaaaaaaat caggaagaaa aaactattaa aataaaataa cctcctaaat   5160

catttggggg tatccccatc                                               5180


<210>  2805
<211>  287
<212>  PRT
<213>  Homo sapiens

<400>  2805


Met Arg Thr Pro Ser Arg Arg Cys Pro Ala Ala His Ser Gly Trp Gln 
1               5                   10                  15      


Thr Tyr Ile Leu Gly Ala Leu Gly Ile Asn Gln Arg Ser His Gln Pro 
            20                  25                  30          


Ser Phe Cys Phe Ser Ser Val Ser Glu Val Val Phe Ser Ser Tyr Pro 
        35                  40                  45              


Gly Phe Ser Thr Ser Glu Val Lys Ser Glu Ile Pro Lys Val Pro Lys 
    50                  55                  60                  


Gln Pro Leu Val Leu His His Pro Arg Met Thr Thr Thr Lys Ser Pro 
65                  70                  75                  80  


Ser Lys Asp Met Leu Glu Pro Glu Ala Glu Leu Ala Glu Asp Leu Pro 
                85                  90                  95      


Thr Thr Lys Ser Thr Ser Val Glu Ser Glu Met Pro Thr Glu Asn Leu 
            100                 105                 110         


Glu Gly His Ser Pro Ser Cys Arg Thr Phe Val Pro Leu Pro Pro Ile 
        115                 120                 125             


Cys Ser Asn Ser Thr Val His Ser Glu Glu Thr Leu Ser His Leu Ser 
    130                 135                 140                 


Asp Thr Thr Val Arg Leu Ser Pro Glu Arg Pro Ser Asp Glu Asp Ser 
145                 150                 155                 160 


Lys Ser Thr Glu Ser Ile Phe Leu Thr Gln Val Ser Glu Leu Pro Ser 
                165                 170                 175     


Ser Val Ile His Lys Asp Asp Leu Glu Leu Lys Glu Lys Asp Gln Lys 
            180                 185                 190         


Lys Pro Pro Thr Ala Pro Arg Glu Val Lys Gly Thr Arg Arg Lys Leu 
        195                 200                 205             


Pro Thr Ala Phe Leu Pro Ser Lys Tyr His Gly Tyr Glu Glu Leu Leu 
    210                 215                 220                 


Thr Ala Lys Pro Asp Pro Ala Phe Ile Glu Pro Lys Gly Ile Gln Lys 
225                 230                 235                 240 


Asn Ala Gln Ala Leu Gln Gln Met Leu Lys His Pro Leu Leu Cys His 
                245                 250                 255     


Ser Ser Lys Pro Lys Leu Asp Thr Leu Gln Lys Pro Tyr Val His Lys 
            260                 265                 270         


Glu Lys Arg Val Asn Ile Gln Leu Thr Glu Cys Val Asn Gly Pro 
        275                 280                 285         

<210>  2806
<211>  4678
<212>  DNA
<213>  Homo sapiens

<400>  2806
gggacttgag gttagacgtc ccggccgtcg gttgccgcct acactgtctg ccgtcgcgtc     60

gcagttacta aggcgtgggg aagatagcgg caggcaccgc agtggagcgg ctccgagatc    120

cccggggggc tcgcaggcgc gcatccctcc tgactgggac gtcgcctccg cagacccctc    180

ggaggctgaa gcgacgccgg aggcaggcca aggacactgg ttagtggttc agaaaggtaa    240

cctcaagaag aagcccaagg gtttggttgg agcacaagct gaacgtcggg aaagcctgaa    300

ggcgacttct tttgagttca aggggaagaa agagtctcgg cgggaaaatc aggtggacct    360

tcctggacat atcctggacc aggcttttct gctgaagcac cactgtgtga ggaagccatc    420

agatctgtgc accattaatg tgagtggcct gaagttctcc aaggccaagg aaaatgactt    480

caagcatttt cattctgtga tttatatcaa tgcctcagaa aacctgctgc ctctagaggc    540

atttcacacg tttccagccc taaaggaact ggatctcgca tttaatggca tcaaaactat    600

ctacgtgaaa tatggagact ttaagttatt agaattcttg gacctttcct tcaacagcct    660

gactgtggag gccatctgtg atttggggat tctgccacac ctccgtgtcc tgctcctcac    720

aggcaatggc cttacctccc tgccgcccaa tttggccgtc gcagaacagg aggcatctgt    780

aacatcgctg acaagcaaga ggtacatcct gaggttccca gcgctggaga cactgatgct    840

ggatgacaac agactctcca accccagttg ctttgccagc ctggctgggc tcaggagact    900

gaagaagtta agcttggatg aaaacaggat tatcaggatc ccatacctac agcaagttca    960

gctctatgac gagtcagtag actggaatgg aggcagggga agtccccata aagagcccca   1020

attcatgctg cagtccaagc caaggatgct tgaggactca gatgagcaac tggattatac   1080

tgtactgccc atgaaaaagg atgttgaccg gacagaggtt gtgttttcat cttaccctgg   1140

attttcaacc tcagagatcg caaaagagga tgctgtccta ccagtagctc tcttcccatc   1200

tctctgcgag ttcgtctttc ataacaaccc tctggtggcc catacacgag gggtccctcc   1260

actgctgaag agcttcctcc aggagcgact gggaatccac ttaattcgaa ggaagatagt   1320

aaagcctaag catcatgttt tgatgtctcg gaaggaatca tggaaggtga aaagcgaaat   1380

cccaaaggtg ccgaagcagc ctctggtgct ccatcacccg cgcatgacga caaccaagtc   1440

tccctcaaag gatatgctag agccagaggc agagctggct gaagatctgc ccactaccaa   1500

aagcacttct gtggagtcag agatgcccac tgagaacctg gaaggccatt ccccgtcttg   1560

ccggaccttc gtgccactgc ctcccatctg ctccaactcc actgtgcata gtgaagagac   1620

cctgtcccac ctgagtgaca caactgtccg cctcagccca gagcgcccat cagatgagga   1680

ctccaagagc acagagtcca tcttcctgac ccaggtgagt gaactgcctt cctccgtcat   1740

ccataaggat gatttagagt taaaggagaa agaccaaaag aaaccaccaa cggcacccag   1800

agaggtgaaa gggactcgga ggaaactccc aactgccttc cttcccagca agtaccacgg   1860

ctatgaagaa ctgctgacag ccaagcctga tccagccttc attgagccaa agggaatcca   1920

gaagaatgca caagccctgc aacaaatgct gaagcaccca ctcctgtgcc actcctccaa   1980

gcccaagctg gacactcttc agaaacccta tgttcacaaa gagaaacggg cccagagaat   2040

cccgattcca cccccaaaga agactagagc ccaacttctg gatgacatct tcattcgctt   2100

gcgggatccc cggaacatta cagaggctcc actaggtgct gtcctgcacc agtggacaga   2160

acggcggctg gtgaaccaca agcagtacct ggaggccaag aggctgttga aggagttcca   2220

ggcacgttac cggcagctgg tgagtggctc tctgcgcaca gtgttcggga ctaccccgct   2280

ccccatggcc tgcccagcgc tgagtgagag ccagcccaag ttcggccact tcctcgagtt   2340

catggatgag ttctgccagg agcccacagc cagtgactca caaggctaga gctgtgcatg   2400

ggggctgtgt gcaccacccg gcctgtgccc cagctctccc cgagggctct gtgccctgga   2460

ccgcacctca aggttgacca gccggccaca ggcctcagag ctcagctggg ccccacttgc   2520

tggccacaag gtggcatccc cttgtcagga tctcccctcc ttggcccagg catgacctgg   2580

tgcctggccc agcggcaata aagagtgggt gcacagggca atagactggg tgccacatgc   2640

attctttctt ggaacccagg ccacagcagc attgtcacac ttccctctaa aaatggtttt   2700

ccagttcaga tgcaacaggg atacatttgt tctctgttgt atgagaaact gacaccaagg   2760

ggatcttaac aaattcctga acaatggctc caaaaaaggg tatttttaaa aaccagatct   2820

tgtgagtaca gccctaatgt gcagggacag tgtcatcctg tatattcgtt ctttactcag   2880

actctttctt ggttccttca ttaggagcat gaatggttga atgtgaacat gacagtaaat   2940

tggagcaaac tgtaaactgg acataactta tgccaaaaga cgtagttgta caccatggaa   3000

accccatccc tgctcctaat ctctactgcc attctgaatg ccaaagcaag acatccaaca   3060

tggggcatct cccagagcac atacagcacc aaaaatccac acacagccta agcttaaccc   3120

atgtttttgt ctgagattgt tcaccagaga caagactctg actataaaca gaacatccac   3180

tttcatgagt ttcctttact gtattctcaa cttgggcctt gcttcaagca ggcaaacata   3240

cattgaagaa tgcactttgg tactgtttaa ataacaacac atcagcccac ttgattccat   3300

gccatgtcct tgctgacaga aacatcccca acagggcatg ccctggtcca agtcctctgt   3360

ctttgtcaaa atgctcttct gatgagttgg agaggaggca gccagcagtg gcagtccaca   3420

aggatccagg taccttctcc aatcctaaag cagacagcag gttgaataaa accaatacac   3480

aacctatttt ctaggcagga ggggaaaagg cccttaggac aataatattt gtacaaagag   3540

ttgagagtaa acaaacagtg tatcaggttc aaaaaaaaaa aaactattcg ttggcattta   3600

aatttttttc ccttgcatag tatctattct ctcactagga cttttaagtg ctctgctgga   3660

ggctcagcgt tggtaatacc atgtttgatg caaacttgaa cccaatgctc tcattggtgg   3720

cacagctttg gagggtggtg gccccaagaa ggggcaatct gcctgctgct atattaatct   3780

ggaaccaggg ccaacagcta ctcttgaact atggtatttg aagagcgagt tcattgcctg   3840

ttttacctta aatgacagga aaggaagatg aacaaacctt gctttgcctt ggcttcaaac   3900

tagttcttga tttaagacac cagaaaggga gagagggagt ctgcttagag tttgaggttg   3960

cctctcacaa gatgacagtt aaaagttgcc accttactta aaaggcatta aggaggcatt   4020

tactcacaaa ggagagagag taaatttttt tcttaagagg aaaaaaatac tgataataca   4080

tagaacaatc tgcacatcca gtcttggcac tttttccaat ttgactgatc tctaaactgg   4140

tgacccttgc atatatctta gtctcttttc tacaatcttc ttcagaaagc tacagcagct   4200

aacaatcatg tataaagatg catttcctag atcatcttca gaagaaaatc tcttcagcac   4260

tttccctaga atctgtctcc tgaccacccc gccccagacc tgctttctct tttgagaatt   4320

cataaccagg tatgtttaga taccagttca aaagaccact ctatgggttg atgaggaaaa   4380

ggctgcctga ggacaattta agaccataat gagtttccaa tttttaaaga aaatttggct   4440

agctggcttt taattcttaa ttaaaatcat taaatttaat taaaattatt ccaatcaaaa   4500

tatatcactt tccaagattc cacattcata ttacttactt atactatgga gactttctct   4560

acctgagcat gtattcaggg gctataggta catttaactc taactaactg aaaaaaatca   4620

ggaagaaaaa actattaaaa taaaataacc tcctaaatca tttgggggta tccccatc     4678


<210>  2807
<211>  517
<212>  PRT
<213>  Homo sapiens

<400>  2807


Met Leu Asp Asp Asn Arg Leu Ser Asn Pro Ser Cys Phe Ala Ser Leu 
1               5                   10                  15      


Ala Gly Leu Arg Arg Leu Lys Lys Leu Ser Leu Asp Glu Asn Arg Ile 
            20                  25                  30          


Ile Arg Ile Pro Tyr Leu Gln Gln Val Gln Leu Tyr Asp Glu Ser Val 
        35                  40                  45              


Asp Trp Asn Gly Gly Arg Gly Ser Pro His Lys Glu Pro Gln Phe Met 
    50                  55                  60                  


Leu Gln Ser Lys Pro Arg Met Leu Glu Asp Ser Asp Glu Gln Leu Asp 
65                  70                  75                  80  


Tyr Thr Val Leu Pro Met Lys Lys Asp Val Asp Arg Thr Glu Val Val 
                85                  90                  95      


Phe Ser Ser Tyr Pro Gly Phe Ser Thr Ser Glu Ile Ala Lys Glu Asp 
            100                 105                 110         


Ala Val Leu Pro Val Ala Leu Phe Pro Ser Leu Cys Glu Phe Val Phe 
        115                 120                 125             


His Asn Asn Pro Leu Val Ala His Thr Arg Gly Val Pro Pro Leu Leu 
    130                 135                 140                 


Lys Ser Phe Leu Gln Glu Arg Leu Gly Ile His Leu Ile Arg Arg Lys 
145                 150                 155                 160 


Ile Val Lys Pro Lys His His Val Leu Met Ser Arg Lys Glu Ser Trp 
                165                 170                 175     


Lys Val Lys Ser Glu Ile Pro Lys Val Pro Lys Gln Pro Leu Val Leu 
            180                 185                 190         


His His Pro Arg Met Thr Thr Thr Lys Ser Pro Ser Lys Asp Met Leu 
        195                 200                 205             


Glu Pro Glu Ala Glu Leu Ala Glu Asp Leu Pro Thr Thr Lys Ser Thr 
    210                 215                 220                 


Ser Val Glu Ser Glu Met Pro Thr Glu Asn Leu Glu Gly His Ser Pro 
225                 230                 235                 240 


Ser Cys Arg Thr Phe Val Pro Leu Pro Pro Ile Cys Ser Asn Ser Thr 
                245                 250                 255     


Val His Ser Glu Glu Thr Leu Ser His Leu Ser Asp Thr Thr Val Arg 
            260                 265                 270         


Leu Ser Pro Glu Arg Pro Ser Asp Glu Asp Ser Lys Ser Thr Glu Ser 
        275                 280                 285             


Ile Phe Leu Thr Gln Val Ser Glu Leu Pro Ser Ser Val Ile His Lys 
    290                 295                 300                 


Asp Asp Leu Glu Leu Lys Glu Lys Asp Gln Lys Lys Pro Pro Thr Ala 
305                 310                 315                 320 


Pro Arg Glu Val Lys Gly Thr Arg Arg Lys Leu Pro Thr Ala Phe Leu 
                325                 330                 335     


Pro Ser Lys Tyr His Gly Tyr Glu Glu Leu Leu Thr Ala Lys Pro Asp 
            340                 345                 350         


Pro Ala Phe Ile Glu Pro Lys Gly Ile Gln Lys Asn Ala Gln Ala Leu 
        355                 360                 365             


Gln Gln Met Leu Lys His Pro Leu Leu Cys His Ser Ser Lys Pro Lys 
    370                 375                 380                 


Leu Asp Thr Leu Gln Lys Pro Tyr Val His Lys Glu Lys Arg Ala Gln 
385                 390                 395                 400 


Arg Ile Pro Ile Pro Pro Pro Lys Lys Thr Arg Ala Gln Leu Leu Asp 
                405                 410                 415     


Asp Ile Phe Ile Arg Leu Arg Asp Pro Arg Asn Ile Thr Glu Ala Pro 
            420                 425                 430         


Leu Gly Ala Val Leu His Gln Trp Thr Glu Arg Arg Leu Val Asn His 
        435                 440                 445             


Lys Gln Tyr Leu Glu Ala Lys Arg Leu Leu Lys Glu Phe Gln Ala Arg 
    450                 455                 460                 


Tyr Arg Gln Leu Val Ser Gly Ser Leu Arg Thr Val Phe Gly Thr Thr 
465                 470                 475                 480 


Pro Leu Pro Met Ala Cys Pro Ala Leu Ser Glu Ser Gln Pro Lys Phe 
                485                 490                 495     


Gly His Phe Leu Glu Phe Met Asp Glu Phe Cys Gln Glu Pro Thr Ala 
            500                 505                 510         


Ser Asp Ser Gln Gly 
        515         

<210>  2808
<211>  5104
<212>  DNA
<213>  Homo sapiens

<400>  2808
aatcgggatc cgtagtttgg gtcttgctgg cgcgaggtag tcagaggacg tggccgcggg     60

gcttgctggg acttgaggtt agacgtcccg gccgtcggtt gccgcctaca ctgtctgccg    120

tcgcgtcgca gttactaagg cgtggggaag atagcggcag gcaccgcagt ggagcggctc    180

cgagatcccc ggggggctcg caggcgcgca tccctcctga ctgggacgtc gcctccgcag    240

acccctcgga ggctgaagcg acgccggagg caggccaagg acactggtta gtggttcaga    300

aaggtaacct caagaagaag cccaagggtt tggttggagc acaagctgaa cgtcgggaaa    360

gcctgaaggc gacttctttt gagttcaagg ggaagaaaga gtctcggcgg gaaaatcagg    420

tggaccttcc tggacatatc ctggaccagg cttttctgct gaagcaccac tgtgtgagga    480

agccatcaga tctgtgcacc attaatgtga gtggcctgaa gttctccaag gccaaggaaa    540

atgacttcaa gcattttcat tctgtgattt atatcaatgc ctcagaaaac ctgctgcctc    600

tagaggcatt tcacacgttt ccagccctaa aggaactgga tctcgcattt aatggcatca    660

aaactatcta cgtgaaatat ggagacttta agttattaga attcttggac ctttccttca    720

acagcctgac tgtggaggcc atctgtgatt tggggattct gccacacctc cgtgtcctgc    780

tcctcacagg caatggcctt acctccctgc cgcccaattt ggccgtcgca gaacaggagg    840

catctgtaac atcgctgaca agcaagaggt acatcctgag gttcccagcg ctggagacac    900

tgatgctgga tgacaacaga ctctccaacc ccagttgctt tgccagcctg gctgggctca    960

ggagactgaa gaagttaagc ttggatgaaa acaggattat caggatccca tacctacagc   1020

aagttcagct ctatgacgag tcagtagact ggaatggagg caggggaagt ccccataaag   1080

agccccaatt catgctgcag tccaagccaa ggatgcttga ggactcagat gagcaactgg   1140

attatactgt actgcccatg aaaaaggatg ttgaccggac agatcgcaaa agaggatgct   1200

gtcctaccag tagctctctt cccatctctc tgcgagttcg tctttcataa caaccctctg   1260

gtggcccata cacgaggggt ccctccactg ctgaagagct tcctccagga gcgactggga   1320

atccacttaa ttcgaaggaa gatagtaaag cctaagcatc atgttttgat gtctcggaag   1380

gaatcatgga aggtgaaaag cgaaatccca aaggtgccga agcagcctct ggtgctccat   1440

cacccgcgca tgacgacaac caagtctccc tcaaaggata tgctagagcc agaggcagag   1500

ctggctgaag atctgcccac taccaaaagc acttctgtgg agtcagagat gcccactgag   1560

aacctggaag gccattcccc gtcttgccgg accttcgtgc cactgcctcc catctgctcc   1620

aactccactg tgcatagtga agagaccctg tcccacctga gtgacacaac tgtccgcctc   1680

agcccagagc gcccatcaga tgaggactcc aagagcacag agtccatctt cctgacccag   1740

gtgagtgaac tgccttcctc cgtcatccat aaggatgatt tagagttaaa ggagaaagac   1800

caaaagaaac caccaacggc acccagagag gtgaaaggga ctcggaggaa actcccaact   1860

gccttccttc ccagcaagta ccacggctat gaagaactgc tgacagccaa gcctgatcca   1920

gccttcattg agccaaaggg aatccagaag aatgcacaag ccctgcaaca aatgctgaag   1980

cacccactcc tgtgccactc ctccaagccc aagctggaca ctcttcagaa accctatgtt   2040

cacaaagaga aacgggccca gagaatcccg attccacccc caaagaagac tagagcccaa   2100

cttctggatg acatcttcat tcgcttgcgg gatccccgga acattacaga ggctccacta   2160

ggtacggctc tgccacagct gccaggatcc cagatccagt tcacgcctgc tggctaaagg   2220

caaagaaagg gcttgtgtca gtgcaggaaa ggcccttaga gagcaactgc ctacatcagt   2280

ctctacatgt agatggacaa aaggagagcc agcgtgaggc agggagttgc ctaaaatcac   2340

acagcatgtt aaggtcctga accagggctt aagatagagt caatgcatag gggcagtagg   2400

aagtcagtga cttcccaagc tggaaaggcc atttttagcc ccttagcatc ctcctgccac   2460

accatcccat tttccaaggg tctctggacc caatcctctt gcttctggct aggtgagaac   2520

caggatgagc ttggtgcctc tcctggcttc ttttcctgca ggtgctgtcc tgcaccagtg   2580

gacagaacgg cggctggtga accacaagca gtacctggag gccaagaggc tgttgaagga   2640

gttccaggca cgttaccggc agctggtgag tggctctctg cgcacagtgt tcgggactac   2700

cccgctcccc atggcctgcc cagcgctgag tgagagccag cccaagttcg gccacttcct   2760

cgagttcatg gatgagttct gccaggagcc cacagccagt gactcacaag gctagagctg   2820

tgcatggggg ctgtgtgcac cacccggcct gtgccccagc tctccccgag ggctctgtgc   2880

cctggaccgc acctcaaggt tgaccagccg gccacaggcc tcagagctca gctgggcccc   2940

acttgctggc cacaaggtgg catccccttg tcaggatctc ccctccttgg cccaggcatg   3000

acctggtgcc tggcccagcg gcaataaaga gtgggtgcac agggcaatag actgggtgcc   3060

acatgcattc tttcttggaa cccaggccac agcagcattg tcacacttcc ctctaaaaat   3120

ggttttccag ttcagatgca acagggatac atttgttctc tgttgtatga gaaactgaca   3180

ccaaggggat cttaacaaat tcctgaacaa tggctccaaa aaagggtatt tttaaaaacc   3240

agatcttgtg agtacagccc taatgtgcag ggacagtgtc atcctgtata ttcgttcttt   3300

actcagactc tttcttggtt ccttcattag gagcatgaat ggttgaatgt gaacatgaca   3360

gtaaattgga gcaaactgta aactggacat aacttatgcc aaaagacgta gttgtacacc   3420

atggaaaccc catccctgct cctaatctct actgccattc tgaatgccaa agcaagacat   3480

ccaacatggg gcatctccca gagcacatac agcaccaaaa atccacacac agcctaagct   3540

taacccatgt ttttgtctga gattgttcac cagagacaag actctgacta taaacagaac   3600

atccactttc atgagtttcc tttactgtat tctcaacttg ggccttgctt caagcaggca   3660

aacatacatt gaagaatgca ctttggtact gtttaaataa caacacatca gcccacttga   3720

ttccatgcca tgtccttgct gacagaaaca tccccaacag ggcatgccct ggtccaagtc   3780

ctctgtcttt gtcaaaatgc tcttctgatg agttggagag gaggcagcca gcagtggcag   3840

tccacaagga tccaggtacc ttctccaatc ctaaagcaga cagcaggttg aataaaacca   3900

atacacaacc tattttctag gcaggagggg aaaaggccct taggacaata atatttgtac   3960

aaagagttga gagtaaacaa acagtgtatc aggttcaaaa aaaaaaaaac tattcgttgg   4020

catttaaatt tttttccctt gcatagtatc tattctctca ctaggacttt taagtgctct   4080

gctggaggct cagcgttggt aataccatgt ttgatgcaaa cttgaaccca atgctctcat   4140

tggtggcaca gctttggagg gtggtggccc caagaagggg caatctgcct gctgctatat   4200

taatctggaa ccagggccaa cagctactct tgaactatgg tatttgaaga gcgagttcat   4260

tgcctgtttt accttaaatg acaggaaagg aagatgaaca aaccttgctt tgccttggct   4320

tcaaactagt tcttgattta agacaccaga aagggagaga gggagtctgc ttagagtttg   4380

aggttgcctc tcacaagatg acagttaaaa gttgccacct tacttaaaag gcattaagga   4440

ggcatttact cacaaaggag agagagtaaa tttttttctt aagaggaaaa aaatactgat   4500

aatacataga acaatctgca catccagtct tggcactttt tccaatttga ctgatctcta   4560

aactggtgac ccttgcatat atcttagtct cttttctaca atcttcttca gaaagctaca   4620

gcagctaaca atcatgtata aagatgcatt tcctagatca tcttcagaag aaaatctctt   4680

cagcactttc cctagaatct gtctcctgac caccccgccc cagacctgct ttctcttttg   4740

agaattcata accaggtatg tttagatacc agttcaaaag accactctat gggttgatga   4800

ggaaaaggct gcctgaggac aatttaagac cataatgagt ttccaatttt taaagaaaat   4860

ttggctagct ggcttttaat tcttaattaa aatcattaaa tttaattaaa attattccaa   4920

tcaaaatata tcactttcca agattccaca ttcatattac ttacttatac tatggagact   4980

ttctctacct gagcatgtat tcaggggcta taggtacatt taactctaac taactgaaaa   5040

aaatcaggaa gaaaaaacta ttaaaataaa ataacctcct aaatcatttg ggggtatccc   5100

catc                                                                5104


<210>  2809
<211>  349
<212>  PRT
<213>  Homo sapiens

<400>  2809


Met Leu Thr Gly Gln Ile Ala Lys Glu Asp Ala Val Leu Pro Val Ala 
1               5                   10                  15      


Leu Phe Pro Ser Leu Cys Glu Phe Val Phe His Asn Asn Pro Leu Val 
            20                  25                  30          


Ala His Thr Arg Gly Val Pro Pro Leu Leu Lys Ser Phe Leu Gln Glu 
        35                  40                  45              


Arg Leu Gly Ile His Leu Ile Arg Arg Lys Ile Val Lys Pro Lys His 
    50                  55                  60                  


His Val Leu Met Ser Arg Lys Glu Ser Trp Lys Val Lys Ser Glu Ile 
65                  70                  75                  80  


Pro Lys Val Pro Lys Gln Pro Leu Val Leu His His Pro Arg Met Thr 
                85                  90                  95      


Thr Thr Lys Ser Pro Ser Lys Asp Met Leu Glu Pro Glu Ala Glu Leu 
            100                 105                 110         


Ala Glu Asp Leu Pro Thr Thr Lys Ser Thr Ser Val Glu Ser Glu Met 
        115                 120                 125             


Pro Thr Glu Asn Leu Glu Gly His Ser Pro Ser Cys Arg Thr Phe Val 
    130                 135                 140                 


Pro Leu Pro Pro Ile Cys Ser Asn Ser Thr Val His Ser Glu Glu Thr 
145                 150                 155                 160 


Leu Ser His Leu Ser Asp Thr Thr Val Arg Leu Ser Pro Glu Arg Pro 
                165                 170                 175     


Ser Asp Glu Asp Ser Lys Ser Thr Glu Ser Ile Phe Leu Thr Gln Val 
            180                 185                 190         


Ser Glu Leu Pro Ser Ser Val Ile His Lys Asp Asp Leu Glu Leu Lys 
        195                 200                 205             


Glu Lys Asp Gln Lys Lys Pro Pro Thr Ala Pro Arg Glu Val Lys Gly 
    210                 215                 220                 


Thr Arg Arg Lys Leu Pro Thr Ala Phe Leu Pro Ser Lys Tyr His Gly 
225                 230                 235                 240 


Tyr Glu Glu Leu Leu Thr Ala Lys Pro Asp Pro Ala Phe Ile Glu Pro 
                245                 250                 255     


Lys Gly Ile Gln Lys Asn Ala Gln Ala Leu Gln Gln Met Leu Lys His 
            260                 265                 270         


Pro Leu Leu Cys His Ser Ser Lys Pro Lys Leu Asp Thr Leu Gln Lys 
        275                 280                 285             


Pro Tyr Val His Lys Glu Lys Arg Ala Gln Arg Ile Pro Ile Pro Pro 
    290                 295                 300                 


Pro Lys Lys Thr Arg Ala Gln Leu Leu Asp Asp Ile Phe Ile Arg Leu 
305                 310                 315                 320 


Arg Asp Pro Arg Asn Ile Thr Glu Ala Pro Leu Gly Thr Ala Leu Pro 
                325                 330                 335     


Gln Leu Pro Gly Ser Gln Ile Gln Phe Thr Pro Ala Gly 
            340                 345                 

<210>  2810
<211>  3121
<212>  DNA
<213>  Homo sapiens

<400>  2810
ttacagcttt gttagtagct ttgcttccac aacaatctgc ttttgtttca ggagtgaaac     60

ttttgaattt ctcagaggat actaattatt ctattttgaa gtttttataa cttttgttaa    120

ataaactgtt tttattcagg tgataattct tccctttttt atattgttaa ttttcctcaa    180

atagtaggag attcttgatt attcagtctt tttgtgtaac aatcctcaat cagaagctta    240

aaatgcagta attcctgtga ttgtggggag agcaggatgc gcgttcagac agcgtgccca    300

tctttctaga ggtgctgttg ttttctaggg ttcattgctt agcactcaca cttgcaacca    360

tggcccatcc cccagggaat tcctactttg ttcattgcac aaagctttcc caaactccct    420

tgcagaccct catcacagga gaagttattt atgccatgtt gttccatctc ctattactgt    480

tttcttcatt ttcatgtgac ttgtctcatt ataatatcat taacatgtag aaggtgtcgg    540

ttaactaggg taaaggtgag caatgtctgc acaggatcta gtcccagcag atgctatgct    600

gtgttaggtt gaactcagct gttagactca tctcattctg acggtcccaa gaatgaaatc    660

actctgcagc ctcctcctta tgactgtgtg ctggttgttc ttggtatctc tcctgaattc    720

actggctcaa cacattctgt ttctactaat ataagaaata tttccaaatc ctctgacaga    780

atgtcttcta tatacatttt tctcttctaa gacagttggt tagctttctg ctcagtatgg    840

actccccagt aattctgagg ctcgaaagtg cttatgtgct ttaaagtcag attgaaggtc    900

agtcagtgtg gctgaaatac agtgaatgag ggagagtatc atgaaatgag actgaagaag    960

taggcagggg cccaatcatg caggacatca gaggactaga taagcagttt gtattttatc   1020

ctaagtgcaa agggacttat tacctgatgc atgtcacagc cagctcctct tcctagttag   1080

cactggggct gaggaccaat gagaactccc tctaggaggt gccctgctgc acacagtgga   1140

tggcagacct atatcctggg tgctctaggc atcaatcagc ggtctcacca accttcattc   1200

tgtttctctt ctgtttcaga ggttgtgttt tcatcttacc ctggattttc aacctcagag   1260

gtgaaaagcg aaatcccaaa ggtgccgaag cagcctctgg tgctccatca cccgcgcatg   1320

acgacaacca agtctccctc aaaggatatg ctagagccag aggcagagct ggctgaagat   1380

ctgcccacta ccaaaagcac ttctgtggag tcagagatgc ccactgagaa cctggaaggc   1440

cattccccgt cttgccggac cttcgtgcca ctgcctccca tctgctccaa ctccactgtg   1500

catagtgaag agaccctgtc ccacctgagt gacacaactg tccgcctcag cccagagcgc   1560

ccatcagatg aggactccaa gagcacagag tccatcttcc tgacccaggt gagtgaactg   1620

ccttcctccg tcatccataa ggatgattta gagttaaagg agaaagacca aaagaaacca   1680

ccaacggcac ccagagaggt gaaagggact cggaggaaac tcccaactgc cttccttccc   1740

agcaagtacc acggctatga agaactgctg acagccaagc ctgatccagc cttcattgag   1800

ccaaagggaa tccagaagaa tgcacaagcc ctgcaacaaa tgctgaagca cccactcctg   1860

tgccactcct ccaagcccaa gctggacact cttcagaaac cctatgttca caaagagaaa   1920

cgggtaaaca tccagctcac tgaatgtgta aatggcccct gagtaccgcc cacaattaca   1980

gatgtggctg tcaccttggg accctctgag ggccatgctt tcccagcacc cccagatgcc   2040

ccccagcctg ttgctgtgac tgtatgaagt taggccaggg aagtctgtgc ataaacctgg   2100

gataacaccc tcctccatga ccttctgcca ggcccagaga atcccgattc cacccccaaa   2160

gaagactaga gcccaacttc tggatgacat cttcattcgc ttgcgggatc cccggaacat   2220

tacagaggct ccactaggta cggctctgcc acagctgcca ggatcccaga tccagttcac   2280

gcctgctggc taaaggcaaa gaaagggctt gtgtcagtgc aggaaaggcc cttagagagc   2340

aactgcctac atcagtctct acatgtagat ggacaaaagg agagccagcg tgaggcaggg   2400

agttgcctaa aatcacacag catgttaagg tcctgaacca gggcttaaga tagagtcaat   2460

gcataggggc agtaggaagt cagtgacttc ccaagctgga aaggccattt ttagcccctt   2520

agcatcctcc tgccacacca tcccattttc caagggtctc tggacccaat cctcttgctt   2580

ctggctaggt gagaaccagg atgagcttgg tgcctctcct ggcttctttt cctgcaggtg   2640

ctgtcctgca ccagtggaca gaacggcggc tggtgaacca caagcagtac ctggaggcca   2700

agaggctgtt gaaggagttc caggcacgtt accggcagct ggtgagtggc tctctgcgca   2760

cagtgttcgg gactaccccg ctccccatgg cctgcccagc gctgagtgag agccagccca   2820

agttcggcca cttcctcgag ttcatggatg agttctgcca ggagcccaca gccagtgact   2880

cacaaggcta gagctgtgca tgggggctgt gtgcaccacc cggcctgtgc cccagctctc   2940

cccgagggct ctgtgccctg gaccgcacct caaggttgac cagccggcca caggcctcag   3000

agctcagctg ggccccactt gctggccaca aggtggcatc cccttgtcag gatctcccct   3060

ccttggccca ggcatgacct ggtgcctggc ccagcggcaa taaagagtgg gtgcacaggg   3120

c                                                                   3121


<210>  2811
<211>  287
<212>  PRT
<213>  Homo sapiens

<400>  2811


Met Arg Thr Pro Ser Arg Arg Cys Pro Ala Ala His Ser Gly Trp Gln 
1               5                   10                  15      


Thr Tyr Ile Leu Gly Ala Leu Gly Ile Asn Gln Arg Ser His Gln Pro 
            20                  25                  30          


Ser Phe Cys Phe Ser Ser Val Ser Glu Val Val Phe Ser Ser Tyr Pro 
        35                  40                  45              


Gly Phe Ser Thr Ser Glu Val Lys Ser Glu Ile Pro Lys Val Pro Lys 
    50                  55                  60                  


Gln Pro Leu Val Leu His His Pro Arg Met Thr Thr Thr Lys Ser Pro 
65                  70                  75                  80  


Ser Lys Asp Met Leu Glu Pro Glu Ala Glu Leu Ala Glu Asp Leu Pro 
                85                  90                  95      


Thr Thr Lys Ser Thr Ser Val Glu Ser Glu Met Pro Thr Glu Asn Leu 
            100                 105                 110         


Glu Gly His Ser Pro Ser Cys Arg Thr Phe Val Pro Leu Pro Pro Ile 
        115                 120                 125             


Cys Ser Asn Ser Thr Val His Ser Glu Glu Thr Leu Ser His Leu Ser 
    130                 135                 140                 


Asp Thr Thr Val Arg Leu Ser Pro Glu Arg Pro Ser Asp Glu Asp Ser 
145                 150                 155                 160 


Lys Ser Thr Glu Ser Ile Phe Leu Thr Gln Val Ser Glu Leu Pro Ser 
                165                 170                 175     


Ser Val Ile His Lys Asp Asp Leu Glu Leu Lys Glu Lys Asp Gln Lys 
            180                 185                 190         


Lys Pro Pro Thr Ala Pro Arg Glu Val Lys Gly Thr Arg Arg Lys Leu 
        195                 200                 205             


Pro Thr Ala Phe Leu Pro Ser Lys Tyr His Gly Tyr Glu Glu Leu Leu 
    210                 215                 220                 


Thr Ala Lys Pro Asp Pro Ala Phe Ile Glu Pro Lys Gly Ile Gln Lys 
225                 230                 235                 240 


Asn Ala Gln Ala Leu Gln Gln Met Leu Lys His Pro Leu Leu Cys His 
                245                 250                 255     


Ser Ser Lys Pro Lys Leu Asp Thr Leu Gln Lys Pro Tyr Val His Lys 
            260                 265                 270         


Glu Lys Arg Val Asn Ile Gln Leu Thr Glu Cys Val Asn Gly Pro 
        275                 280                 285         

<210>  2812
<211>  2598
<212>  DNA
<213>  Homo sapiens

<400>  2812
agtttgggtc ttgctggcgc gaggtagtca gaggacgtgg ccgcggggct tgctgggact     60

tgaggttaga cgtcccggcc gtcggttgcc gcctacactg tctgccgtcg cgtcgcagtt    120

actaaggcgt ggggaagata gcggcaggca ccgcagtgga gcggctccga gatccccggg    180

gggctcgcag gcgcgcatcc ctcctgactg ggacgtcgcc tccgcagacc cctcggaggc    240

tgaagcgacg ccggaggcag gcaaagaaac aagtgaagaa acaaaaaaaa aaggaagtta    300

aggggccatt cccaaagtca aagatcaagg agatggcctt ctcaggaatc tacaagctgg    360

atgatgggaa gccttacctg aacaactgct tcccagccag aaatctgctt cgcgtgccgg    420

aggaaggcca aggacactgg ttagtggttc agaaaggtaa cctcaagaag aagcccaagg    480

gtttggttgg agcacaagct gaacgtcggg aaagcctgaa ggcgacttct tttgagttca    540

aggggaagaa agagtctcgg cgggaaaatc aggtggacct tcctggacat atcctggacc    600

aggcttttct gctgaagcac cactgtgtga ggaagccatc agatctgtgc accattaatg    660

tgagtggcct gaagttctcc aaggccaagg aaaatgactt caagcatttt cattctgtga    720

tttatatcaa tgcctcagaa aacctgctgc ctctagaggc atttcacacg tttccagccc    780

taaaggaact ggatctcgca tttaatggca tcaaaactat ctacgtgaaa tatggagact    840

ttaagttatt agaattcttg gacctttcct tcaacagcct gactgtggag gccatctgtg    900

atttggggat tctgccacac ctccgtgtcc tgctcctcac aggcaatggc cttacctccc    960

tgccgcccaa tttggccgtc gcagaacagg aggcatctgt aacatcgctg acaagcaaga   1020

ggtacatcct gaggttccca gcgctggaga cactgatgct ggatgacaac agactctcca   1080

accccagttg ctttgccagc ctggctgggc tcaggagact gaagaagtta agcttggatg   1140

aaaacaggat tatcaggatc ccatacctac agcaagttca gctctatgac gagtcagtag   1200

actggaatgg aggcagggga agtccccata aagagcccca attcatgctg cagtccaagc   1260

caaggatgct tgaggactca gatgagcaac tggattatac tgtactgccc atgaaaaagg   1320

atgttgaccg gacaggggtc cctccactgc tgaagagctt cctccaggag cgactgggaa   1380

tccacttaat tcgaaggaag atagtaaagc ctaagcatca tgttttgatg tctcggaagg   1440

aatcatggaa ggtgaaaagc gaaatcccaa aggtgccgaa gcagcctctg gtgctccatc   1500

acccgcgcat gacgacaacc aagtctccct caaaggatat gctagagcca gaggcagagc   1560

tggctgaaga tctgcccact accaaaagca cttctgtgga gtcagagatg cccactgaga   1620

acctggaagg ccattccccg tcttgccgga ccttcgtgcc actgcctccc atctgctcca   1680

actccactgt gcatagtgaa gagaccctgt cccacctgag tgacacaact gtccgcctca   1740

gcccagagcg cccatcagat gaggactcca agagcacaga gtccatcttc ctgacccagg   1800

tgagtgaact gccttcctcc gtcatccata aggatgattt agagttaaag gagaaagacc   1860

aaaagaaacc accaacggca cccagagagg tgaaagggac tcggaggaaa ctcccaactg   1920

ccttccttcc cagcaagtac cacggctatg aagaactgct gacagccaag cctgatccag   1980

ccttcattga gccaaaggga atccagaaga atgcacaagc cctgcaacaa atgctgaagc   2040

acccactcct gtgccactcc tccaagccca agctggacac tcttcagaaa ccctatgttc   2100

acaaagagaa acgggtgctg tcctgcacca gtggacagaa cggcggctgg tgaaccacaa   2160

gcagtacctg gaggccaaga ggctgttgaa ggagttccag gcacgttacc ggcagctggt   2220

gagtggctct ctgcgcacag tgttcgggac taccccgctc cccatggcct gcccagcgct   2280

gagtgagagc cagcccaagt tcggccactt cctcgagttc atggatgagt tctgccagga   2340

gcccacagcc agtgactcac aaggctagag ctgtgcatgg gggctgtgtg caccacccgg   2400

cctgtgcccc agctctcccc gagggctctg tgccctggac cgcacctcaa ggttgaccag   2460

ccggccacag gcctcagagc tcagctgggc cccacttgct ggccacaagg tggcatcccc   2520

ttgtcaggat ctcccctcct tggcccaggc atgacctggt gcctggccca gcggcaataa   2580

agagtgggtg cacagggc                                                 2598


<210>  2813
<211>  606
<212>  PRT
<213>  Homo sapiens

<400>  2813


Met Ala Phe Ser Gly Ile Tyr Lys Leu Asp Asp Gly Lys Pro Tyr Leu 
1               5                   10                  15      


Asn Asn Cys Phe Pro Ala Arg Asn Leu Leu Arg Val Pro Glu Glu Gly 
            20                  25                  30          


Gln Gly His Trp Leu Val Val Gln Lys Gly Asn Leu Lys Lys Lys Pro 
        35                  40                  45              


Lys Gly Leu Val Gly Ala Gln Ala Glu Arg Arg Glu Ser Leu Lys Ala 
    50                  55                  60                  


Thr Ser Phe Glu Phe Lys Gly Lys Lys Glu Ser Arg Arg Glu Asn Gln 
65                  70                  75                  80  


Val Asp Leu Pro Gly His Ile Leu Asp Gln Ala Phe Leu Leu Lys His 
                85                  90                  95      


His Cys Val Arg Lys Pro Ser Asp Leu Cys Thr Ile Asn Val Ser Gly 
            100                 105                 110         


Leu Lys Phe Ser Lys Ala Lys Glu Asn Asp Phe Lys His Phe His Ser 
        115                 120                 125             


Val Ile Tyr Ile Asn Ala Ser Glu Asn Leu Leu Pro Leu Glu Ala Phe 
    130                 135                 140                 


His Thr Phe Pro Ala Leu Lys Glu Leu Asp Leu Ala Phe Asn Gly Ile 
145                 150                 155                 160 


Lys Thr Ile Tyr Val Lys Tyr Gly Asp Phe Lys Leu Leu Glu Phe Leu 
                165                 170                 175     


Asp Leu Ser Phe Asn Ser Leu Thr Val Glu Ala Ile Cys Asp Leu Gly 
            180                 185                 190         


Ile Leu Pro His Leu Arg Val Leu Leu Leu Thr Gly Asn Gly Leu Thr 
        195                 200                 205             


Ser Leu Pro Pro Asn Leu Ala Val Ala Glu Gln Glu Ala Ser Val Thr 
    210                 215                 220                 


Ser Leu Thr Ser Lys Arg Tyr Ile Leu Arg Phe Pro Ala Leu Glu Thr 
225                 230                 235                 240 


Leu Met Leu Asp Asp Asn Arg Leu Ser Asn Pro Ser Cys Phe Ala Ser 
                245                 250                 255     


Leu Ala Gly Leu Arg Arg Leu Lys Lys Leu Ser Leu Asp Glu Asn Arg 
            260                 265                 270         


Ile Ile Arg Ile Pro Tyr Leu Gln Gln Val Gln Leu Tyr Asp Glu Ser 
        275                 280                 285             


Val Asp Trp Asn Gly Gly Arg Gly Ser Pro His Lys Glu Pro Gln Phe 
    290                 295                 300                 


Met Leu Gln Ser Lys Pro Arg Met Leu Glu Asp Ser Asp Glu Gln Leu 
305                 310                 315                 320 


Asp Tyr Thr Val Leu Pro Met Lys Lys Asp Val Asp Arg Thr Gly Val 
                325                 330                 335     


Pro Pro Leu Leu Lys Ser Phe Leu Gln Glu Arg Leu Gly Ile His Leu 
            340                 345                 350         


Ile Arg Arg Lys Ile Val Lys Pro Lys His His Val Leu Met Ser Arg 
        355                 360                 365             


Lys Glu Ser Trp Lys Val Lys Ser Glu Ile Pro Lys Val Pro Lys Gln 
    370                 375                 380                 


Pro Leu Val Leu His His Pro Arg Met Thr Thr Thr Lys Ser Pro Ser 
385                 390                 395                 400 


Lys Asp Met Leu Glu Pro Glu Ala Glu Leu Ala Glu Asp Leu Pro Thr 
                405                 410                 415     


Thr Lys Ser Thr Ser Val Glu Ser Glu Met Pro Thr Glu Asn Leu Glu 
            420                 425                 430         


Gly His Ser Pro Ser Cys Arg Thr Phe Val Pro Leu Pro Pro Ile Cys 
        435                 440                 445             


Ser Asn Ser Thr Val His Ser Glu Glu Thr Leu Ser His Leu Ser Asp 
    450                 455                 460                 


Thr Thr Val Arg Leu Ser Pro Glu Arg Pro Ser Asp Glu Asp Ser Lys 
465                 470                 475                 480 


Ser Thr Glu Ser Ile Phe Leu Thr Gln Val Ser Glu Leu Pro Ser Ser 
                485                 490                 495     


Val Ile His Lys Asp Asp Leu Glu Leu Lys Glu Lys Asp Gln Lys Lys 
            500                 505                 510         


Pro Pro Thr Ala Pro Arg Glu Val Lys Gly Thr Arg Arg Lys Leu Pro 
        515                 520                 525             


Thr Ala Phe Leu Pro Ser Lys Tyr His Gly Tyr Glu Glu Leu Leu Thr 
    530                 535                 540                 


Ala Lys Pro Asp Pro Ala Phe Ile Glu Pro Lys Gly Ile Gln Lys Asn 
545                 550                 555                 560 


Ala Gln Ala Leu Gln Gln Met Leu Lys His Pro Leu Leu Cys His Ser 
                565                 570                 575     


Ser Lys Pro Lys Leu Asp Thr Leu Gln Lys Pro Tyr Val His Lys Glu 
            580                 585                 590         


Lys Arg Val Leu Ser Cys Thr Ser Gly Gln Asn Gly Gly Trp 
        595                 600                 605     

<210>  2814
<211>  1457
<212>  DNA
<213>  Homo sapiens

<400>  2814
agaaaactgt tccaagaaac taaccttcct tgggtcactc ttcttcccat ggctttactg     60

tggcgataaa agtcacagga atggactcct ggatgcatca ctcaagtcaa agcctggaaa    120

cctgagagag agagcaaccc cagacagccc agaggaatgt cctggatatc catgtgaaga    180

aataggagat cttaagctga aaatcataaa agataagtaa atgagtaagg gctattcatc    240

ctactcagtc ccactcctac cttatcagat actttcagtt atttctactt ttcctctcga    300

gattcgctgt gagatactag aacttctttt tgatgcatac ttgtgggaag attttgatta    360

tccatgagat tacagttgta acttcataga ctcccaaagg gaaattcttg aaagatcact    420

ctggctgaca gataggagga tgggctggga ggcaagaaac tgcagactgg gaccaaacag    480

gaggataaca gcaatgagca gagataaggt ctcactacgt tgcccaggct ggcctcaaac    540

tcctgggctc aaacaatcct cctgcctcag cctcccaaag tgctgggatt acaagtgtga    600

gtgaccatgc ctggccaacc cacagctttc aaagcgtgct gatttcaact gctactctga    660

tgcagaatat catactgact ggacctggcg agcaggaaaa gttgcaaaca ccctagatgc    720

cttagtaaga tacctgtgtg ttacaggatg gagcctgact ggctcatgga gaaagcctac    780

ctaagaatga agccgggacc cggcagaatg gctcctgtga agaagggtgg caagaagaaa    840

aagggccgtt ctgccatcaa tgaggtggtg acccgagaat acaccatcaa cattcacaag    900

tgcatccatg gagtgggctt caagaagcat gccccttgag cactcaaaga gattcggaaa    960

tttgtcagga aggagatggg aactctagat gtgcacaact gataccaggc tcaacaaggc   1020

tgtctgggcc aaaggaataa ggaatgtccc atgccgaatc catgtgcagt tgtccagaga   1080

atataatgag gatgaagatt caccaaataa gctctgtact tcggttacct atgtacctgt   1140

taccactttc aaaaatctat agacagtcat tgtggatgag aactaatcac tgattgtcaa   1200

ctatatcaaa caaagttata aaactgcaaa aaaaaaaaaa aaaatgaagc caacaccaag   1260

gaaaacaaag atgtcttcat gtgtatgaca gaacaagtaa cagactaaca gaagctgcac   1320

acatgctcaa gaaatagaga tgcacgcaga gacctgacaa catcctgtgc gcctatatcc   1380

agccaaagca tccagcagac tgacctcatg atttttcaca tacatgaacc aataaattcc   1440

cttttttgtt taagcca                                                  1457


<210>  2815
<211>  63
<212>  PRT
<213>  Homo sapiens

<400>  2815


Met Glu Pro Asp Trp Leu Met Glu Lys Ala Tyr Leu Arg Met Lys Pro 
1               5                   10                  15      


Gly Pro Gly Arg Met Ala Pro Val Lys Lys Gly Gly Lys Lys Lys Lys 
            20                  25                  30          


Gly Arg Ser Ala Ile Asn Glu Val Val Thr Arg Glu Tyr Thr Ile Asn 
        35                  40                  45              


Ile His Lys Cys Ile His Gly Val Gly Phe Lys Lys His Ala Pro 
    50                  55                  60              

<210>  2816
<211>  416
<212>  DNA
<213>  Homo sapiens

<400>  2816
aaaacaaatt caacagtata ttaagaagat cattcatcgg ccaggcgcag tggctcatgc     60

ctgtaatccc agcactttgg gaggccaagg tgggcggatc acctgaggtc gggagttcaa    120

gaccagcctg atcaacatgg agaaacccca tgtctactga aaatacaaaa ttagccaggc    180

atggtggcat atgcctgtaa tcccagctcc caaagtgctg ggattacaag tgtgagtgac    240

catgcctggc caacccacag ctttcaaagc gtgctgattt caactgctac tctgatgcag    300

gtaggaatac atttattctc cccctcatat ataagaacat gaaagtgcag ggtgggggag    360

acttgcctta ttttatgtaa ctaggctttc cactgaaaac aactagaatg atgaat        416


<210>  2817
<211>  53
<212>  PRT
<213>  Homo sapiens

<400>  2817


Met Val Ala Tyr Ala Cys Asn Pro Ser Ser Gln Ser Ala Gly Ile Thr 
1               5                   10                  15      


Ser Val Ser Asp His Ala Trp Pro Thr His Ser Phe Gln Ser Val Leu 
            20                  25                  30          


Ile Ser Thr Ala Thr Leu Met Gln Val Gly Ile His Leu Phe Ser Pro 
        35                  40                  45              


Ser Tyr Ile Arg Thr 
    50              

<210>  2818
<211>  894
<212>  DNA
<213>  Homo sapiens

<400>  2818
aaagcagtct gctttcacct gacagggaca acagtacacc tttttcctct tctcttgggg     60

ccatatcaac tccgggatct tggttatttt gatatcctac agaatatcat actgactgga    120

cctggcgagc aggaaaagtt gcaaacaccc tagatgcctt agtaagatac ctgtgtgtta    180

caggatggag cctgactggc tcatggagaa agcctaccta agaatgaagc cgggacccgg    240

cagaatggct cctgtgaaga agggtggcaa gaagaaaaag ggccgttctg ccatcaatga    300

ggtggtgacc cgagaataca ccatcaacat tcacaagtgc atccatggag tgggcttcaa    360

gaagcatgcc ccttgagcac tcaaagagat tcggaaattt gtcaggaagg agatgggaac    420

tctagatgtg cacaactgat accaggctca acaaggctgt ctgggccaaa ggaataagga    480

atgtcccatg ccgaatccat gtgcagttgt ccagagaata taatgaggat gaagattcac    540

caaataagct ctgtacttcg gttacctatg tacctgttac cactttcaaa aatctataga    600

cagtcattgt ggatgagaac taatcactga ttgtcaacta tatcaaacaa agttataaaa    660

ctgcaaaaaa aaaaaaaaaa atgaagccaa caccaaggaa aacaaagatg tcttcatgtg    720

tatgacagaa caagtaacag actaacagaa gctgcacaca tgctcaagaa atagagatgc    780

acgcagagac ctgacaacat cctgtgcgcc tatatccagc caaagcatcc agcagactga    840

cctcatgatt tttcacatac atgaaccaat aaattccctt ttttgtttaa gcca          894


<210>  2819
<211>  63
<212>  PRT
<213>  Homo sapiens

<400>  2819


Met Glu Pro Asp Trp Leu Met Glu Lys Ala Tyr Leu Arg Met Lys Pro 
1               5                   10                  15      


Gly Pro Gly Arg Met Ala Pro Val Lys Lys Gly Gly Lys Lys Lys Lys 
            20                  25                  30          


Gly Arg Ser Ala Ile Asn Glu Val Val Thr Arg Glu Tyr Thr Ile Asn 
        35                  40                  45              


Ile His Lys Cys Ile His Gly Val Gly Phe Lys Lys His Ala Pro 
    50                  55                  60              

<210>  2820
<211>  901
<212>  DNA
<213>  Homo sapiens

<400>  2820
ctgtcagcag cagcagtgat agtgcaacag caatggcagt actaaccatg gtaactgcgt     60

tggcagagat tccagccttg gttgaggcat cacatcttca gcaggtctac aattacagtg    120

acaccctccc tgaaagccca gcagtggata tagacttgtt gacttcagtt tagcagtgat    180

gcagcttctg atctctgcct gactggctca tggagaaagc ctacctaaga atgaagccgg    240

gacccggcag aatggctcct gtgaagaagg gtggcaagaa gaaaaagggc cgttctgcca    300

tcaatgaggt ggtgacccga gaatacacca tcaacattca caagtgcatc catggagtgg    360

gcttcaagaa gcatgcccct tgagcactca aagagattcg gaaatttgtc aggaaggaga    420

tgggaactct agatgtgcac aactgatacc aggctcaaca aggctgtctg ggccaaagga    480

ataaggaatg tcccatgccg aatccatgtg cagttgtcca gagaatataa tgaggatgaa    540

gattcaccaa ataagctctg tacttcggtt acctatgtac ctgttaccac tttcaaaaat    600

ctatagacag tcattgtgga tgagaactaa tcactgattg tcaactatat caaacaaagt    660

tataaaactg caaaaaaaaa aaaaaaaatg aagccaacac caaggaaaac aaagatgtct    720

tcatgtgtat gacagaacaa gtaacagact aacagaagct gcacacatgc tcaagaaata    780

gagatgcacg cagagacctg acaacatcct gtgcgcctat atccagccaa agcatccagc    840

agactgacct catgattttt cacatacatg aaccaataaa ttcccttttt tgtttaagcc    900

a                                                                    901


<210>  2821
<211>  57
<212>  PRT
<213>  Homo sapiens

<400>  2821


Met Cys Thr Thr Asp Thr Arg Leu Asn Lys Ala Val Trp Ala Lys Gly 
1               5                   10                  15      


Ile Arg Asn Val Pro Cys Arg Ile His Val Gln Leu Ser Arg Glu Tyr 
            20                  25                  30          


Asn Glu Asp Glu Asp Ser Pro Asn Lys Leu Cys Thr Ser Val Thr Tyr 
        35                  40                  45              


Val Pro Val Thr Thr Phe Lys Asn Leu 
    50                  55          

<210>  2822
<211>  563
<212>  DNA
<213>  Homo sapiens

<400>  2822
agtcagagga cgtggccgcg gggcttgctg ggacttgagg ttagacgtcc cggccgtcgg     60

ttgccgccta cactgtctgc cgtcgcgtcg cagttactaa ggcgtgggga agatagcggc    120

aggcaccgca gtggagcggc tccgagatcc ccggggggct cgcaggcgcg catccctcct    180

gactgggacg tcgcctccgc agacccctcg gaggctgaag cgacgccgga ggcaggcaaa    240

gaaacaagtg aagaaacaaa aaaaaaagga agttaagggg ccattcccaa agtcaaagat    300

caagccaagg acactggtta gtggttcaga aaggtaacct caagaagaag cccaagggtt    360

tggttggagc acaagctgaa cgtcgggaaa gcctgaaggc gacttctttt gagttcaagg    420

ggaagaaaga gtctcggcgg gaaaatcagg tggaccttcc tggacatatc ctggaccagg    480

cttttctggc caaggaaaat gacttcaagc attttcattc tgtgatttat atcaatgcct    540

cagaaaacct gctgcctcta ggt                                            563


<210>  2823
<211>  103
<212>  PRT
<213>  Homo sapiens

<400>  2823


Arg Asn Lys Lys Lys Arg Lys Leu Arg Gly His Ser Gln Ser Gln Arg 
1               5                   10                  15      


Ser Ser Gln Gly His Trp Leu Val Val Gln Lys Gly Asn Leu Lys Lys 
            20                  25                  30          


Lys Pro Lys Gly Leu Val Gly Ala Gln Ala Glu Arg Arg Glu Ser Leu 
        35                  40                  45              


Lys Ala Thr Ser Phe Glu Phe Lys Gly Lys Lys Glu Ser Arg Arg Glu 
    50                  55                  60                  


Asn Gln Val Asp Leu Pro Gly His Ile Leu Asp Gln Ala Phe Leu Ala 
65                  70                  75                  80  


Lys Glu Asn Asp Phe Lys His Phe His Ser Val Ile Tyr Ile Asn Ala 
                85                  90                  95      


Ser Glu Asn Leu Leu Pro Leu 
            100             

<210>  2824
<211>  610
<212>  DNA
<213>  Homo sapiens

<400>  2824
gtcttgctgg cgcgaggtag tcagaggacg tggccgcggg gcttgctggg acttgaggtt     60

agacgtcccg gccgtcggtt gccgcctaca ctgtctgccg tcgcgtcgca gttactaagg    120

cgtggggaag atagcggcag gcaccgcagt ggagcggctc cgagatcccc ggggggctcg    180

caggcgcgca tccctcctga ctgggacgtc gcctccgcag acccctcgga ggctgaagcg    240

acgccggagg caggcaaaga aacaagtgaa gaaacaaaaa aaaaaggaag ttaaggggcc    300

attcccaaag tcaaagatca agccaaggac actggttagt ggttcagaaa ggtaacctca    360

agaagaagcc caagggtttg gttggagcac aagctgaacg tcgggaaagc ctgaaggcga    420

cttcttttga gttcaagggg aagaaagagt ctcggcggga aaatcaggtg gaccttcctg    480

gacatatcct ggaccaggct tttctgctga agcaccactg tgtgaggaag ccatcagatc    540

tgtgcaccat taatgtgagt ggcctgaagt tctccaagct tgataggagc atatcattaa    600

agaaactctt                                                           610


<210>  2825
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  2825


Arg Asn Lys Lys Lys Arg Lys Leu Arg Gly His Ser Gln Ser Gln Arg 
1               5                   10                  15      


Ser Ser Gln Gly His Trp Leu Val Val Gln Lys Gly Asn Leu Lys Lys 
            20                  25                  30          


Lys Pro Lys Gly Leu Val Gly Ala Gln Ala Glu Arg Arg Glu Ser Leu 
        35                  40                  45              


Lys Ala Thr Ser Phe Glu Phe Lys Gly Lys Lys Glu Ser Arg Arg Glu 
    50                  55                  60                  


Asn Gln Val Asp Leu Pro Gly His Ile Leu Asp Gln Ala Phe Leu Leu 
65                  70                  75                  80  


Lys His His Cys Val Arg Lys Pro Ser Asp Leu Cys Thr Ile Asn Val 
                85                  90                  95      


Ser Gly Leu Lys Phe Ser Lys Leu Asp Arg Ser Ile Ser Leu Lys Lys 
            100                 105                 110         

<210>  2826
<211>  508
<212>  DNA
<213>  Homo sapiens

<400>  2826
agaggcggac aagatggcgg cggcagctgt acagggcggg agaagcggtg gtagcggagg     60

ctgtagtggg gctggtggtg cttccaactg cgggacagga agtggccgta gcggcttgtt    120

ggataagtgg aagatagatg ataagcctgt aaaaattgac aagtgggatg gatcagctgt    180

gaaaaactct ttggatgatt ctgccaaaaa ggtacttctg gaaaaataca aatatgtgga    240

gaattttggt ctaattgatg gtcgcctcac catctgtaca atctcctgtt tctttgccat    300

agtggctttg atttgggatt atatgcaccc ctttccagag tccaaacccg ttttggcttt    360

gtgtgtcata acctattttg tgatgatggg gattctgacc atttatacct catataagga    420

gaagagcatc tttctcgtgg cccacaggaa agatcctaca ggaatggatc ctgatgatat    480

ttggcagctg tcctccagtc ttaaaagg                                       508


<210>  2827
<211>  164
<212>  PRT
<213>  Homo sapiens

<400>  2827


Met Ala Ala Ala Ala Val Gln Gly Gly Arg Ser Gly Gly Ser Gly Gly 
1               5                   10                  15      


Cys Ser Gly Ala Gly Gly Ala Ser Asn Cys Gly Thr Gly Ser Gly Arg 
            20                  25                  30          


Ser Gly Leu Leu Asp Lys Trp Lys Ile Asp Asp Lys Pro Val Lys Ile 
        35                  40                  45              


Asp Lys Trp Asp Gly Ser Ala Val Lys Asn Ser Leu Asp Asp Ser Ala 
    50                  55                  60                  


Lys Lys Val Leu Leu Glu Lys Tyr Lys Tyr Val Glu Asn Phe Gly Leu 
65                  70                  75                  80  


Ile Asp Gly Arg Leu Thr Ile Cys Thr Ile Ser Cys Phe Phe Ala Ile 
                85                  90                  95      


Val Ala Leu Ile Trp Asp Tyr Met His Pro Phe Pro Glu Ser Lys Pro 
            100                 105                 110         


Val Leu Ala Leu Cys Val Ile Thr Tyr Phe Val Met Met Gly Ile Leu 
        115                 120                 125             


Thr Ile Tyr Thr Ser Tyr Lys Glu Lys Ser Ile Phe Leu Val Ala His 
    130                 135                 140                 


Arg Lys Asp Pro Thr Gly Met Asp Pro Asp Asp Ile Trp Gln Leu Ser 
145                 150                 155                 160 


Ser Ser Leu Lys 
                

<210>  2828
<211>  662
<212>  DNA
<213>  Homo sapiens

<400>  2828
ggacaagatg gcggcggcag ctgtacaggg cgggagaagc ggtggtagcg gaggctgtag     60

tggggctggt ggtgcttcca actgcgggac aggaagtggc cgtagcggct tgttggataa    120

ggtgaggagc cggttcttgg gaacagttga atcctgggga ggcctgggag gcggcgagcc    180

aaccttccca tcccggtctc ccttattttc tacggccttt tgaggggagc ccttgtgtga    240

ccactatcac aaccctacgc acgcttggag cctgcccttg ccctcatcac acttcaaacc    300

tggacccggt cctctttaga acttcttctt ttctcgcaag tgttctggtc ctggtcgcca    360

cacctttttc gtggaagata gatgataagc ctgtaaaaat tgacaagtgg gatggatcag    420

ctgtgaaaaa ctctttggat gattctgcca aaaagtggct ttgatttggg attatatgca    480

cccctttcca gagtccaaac ccgttttggc tttgtgtgtc ataacctatt ttgtgatgat    540

ggggattctg accatttata cctcatataa ggagaagagc atctttctcg tggcccacag    600

gaaagatcct acaggaatgg atcctgatga tatttggcag ctgtcctcca gtcttaaaag    660

gt                                                                   662


<210>  2829
<211>  61
<212>  PRT
<213>  Homo sapiens

<400>  2829


Met His Pro Phe Pro Glu Ser Lys Pro Val Leu Ala Leu Cys Val Ile 
1               5                   10                  15      


Thr Tyr Phe Val Met Met Gly Ile Leu Thr Ile Tyr Thr Ser Tyr Lys 
            20                  25                  30          


Glu Lys Ser Ile Phe Leu Val Ala His Arg Lys Asp Pro Thr Gly Met 
        35                  40                  45              


Asp Pro Asp Asp Ile Trp Gln Leu Ser Ser Ser Leu Lys 
    50                  55                  60      

<210>  2830
<211>  613
<212>  DNA
<213>  Homo sapiens

<400>  2830
gttcttggga acagttgaat cctggggagg cctgggaggc ggcgagccaa ccttcccatc     60

ccggtctccc ttattttcta cggccttttg aggggagccc ttgtgtgacc actatcacaa    120

ccctacgcac gcttggagcc tgcccttgcc ctcatcacac ttcaaacctg gacccggtcc    180

tctttagaac ttcttctttt ctcgcaagtg ttctggtcct ggtcgccaca cctttttcgt    240

ggaagataga tgataagcct gtaaaaattg acaagtggga tggatcagct gtgaaaaact    300

ctttggatga ttctgccaaa aaggtacttc tggaaaaata caaatatgtg gagaattttg    360

gtctaattga tggtcgcctc accatctgta caatctcctg tttctttgcc atagtggctt    420

tgatttggga ttatatgcac ccctttccag agtccaaacc cgttttggct ttgtgtgtca    480

taacctattt tgtgatgatg gggattctga ccatttatac ctcatataag gagaagagca    540

tctttctcgt ggcccacagg aaagatccta caggaatgga tcctgatgat atttggcagc    600

tgtcctccag tct                                                       613


<210>  2831
<211>  58
<212>  PRT
<213>  Homo sapiens

<400>  2831


Met His Pro Phe Pro Glu Ser Lys Pro Val Leu Ala Leu Cys Val Ile 
1               5                   10                  15      


Thr Tyr Phe Val Met Met Gly Ile Leu Thr Ile Tyr Thr Ser Tyr Lys 
            20                  25                  30          


Glu Lys Ser Ile Phe Leu Val Ala His Arg Lys Asp Pro Thr Gly Met 
        35                  40                  45              


Asp Pro Asp Asp Ile Trp Gln Leu Ser Ser 
    50                  55              

<210>  2832
<211>  1014
<212>  DNA
<213>  Homo sapiens

<400>  2832
cctattttgt gatgatgggg attctgacca tttatacctc atataaggag aagagcatct     60

ttctcgtggc ccacaggaaa gatcctacag gaatggatcc tgatgatatt tggcagctgt    120

cctccagtct taaaaggttt gatgacaaat acaccttgaa gctgaccttc atcagtggga    180

gaacaaagca gcagcgggaa gccgagttca caaagtccat tgctaagttt tttgaccaca    240

gtgggacact ggtcatggat gcatatgagc ctgaaatatc caggctccat gacagtcttg    300

ccatagaaag aaaaataaag tagccaattc taaaagtagc cctctttctc ctggatcttg    360

ctgaattagt ggcttggggg gtgggggaga taaaaagaac ttaaaatggg taaagtaaga    420

aatgttaaaa agtccctgtt ttgtcctgaa attttagtct attctgggta aataggattt    480

tctgacacag atatgagaag ttgtagctct gatgtctagc tgtagtctcc ttgatctgct    540

gattgcatta ttttaatttg cttttctggg aaagcagttt tgctaaaagc tgtacagact    600

ttttcttttg tacctagcag tactttatat agtatagctt tgggccatgt agcattttaa    660

gactcaattt taaaaaatta ttaatctgtt gctgactctt aattcctatt tcaatatgtg    720

tttccttgaa gaattcagga tacaacttct tgtgtatgac agctttcctt cacacactat    780

ttttgtgggt gtgtatatat ctgatttggg aagaatttaa aaaacacata gctttttaat    840

ttgtttgaaa cagactttct gcctgttaca tttttgcttt taaccaatta aagaagccaa    900

tggcatttta gttttatatt gtgttttcca ctagtatatc cctgttgatt tgtttgtgcc    960

ttttattaac tgccattttc taaaattttt ttcaataaaa ggaaggaaga tgtg         1014


<210>  2833
<211>  103
<212>  PRT
<213>  Homo sapiens

<400>  2833


Met Met Gly Ile Leu Thr Ile Tyr Thr Ser Tyr Lys Glu Lys Ser Ile 
1               5                   10                  15      


Phe Leu Val Ala His Arg Lys Asp Pro Thr Gly Met Asp Pro Asp Asp 
            20                  25                  30          


Ile Trp Gln Leu Ser Ser Ser Leu Lys Arg Phe Asp Asp Lys Tyr Thr 
        35                  40                  45              


Leu Lys Leu Thr Phe Ile Ser Gly Arg Thr Lys Gln Gln Arg Glu Ala 
    50                  55                  60                  


Glu Phe Thr Lys Ser Ile Ala Lys Phe Phe Asp His Ser Gly Thr Leu 
65                  70                  75                  80  


Val Met Asp Ala Tyr Glu Pro Glu Ile Ser Arg Leu His Asp Ser Leu 
                85                  90                  95      


Ala Ile Glu Arg Lys Ile Lys 
            100             

<210>  2834
<211>  2313
<212>  DNA
<213>  Homo sapiens

<400>  2834
cctattttgt gatgatgggg attctgacca tttatacctc atataaggag aagagcatct     60

ttctcgtggc ccacaggaaa gatcctacag gaatggatcc tgatgatatt tggcagctgt    120

cctccagtct taaaaggttt gatgacaaat acaccttgaa gctgaccttc atcagtggga    180

gaacaaagca gcagcgggaa gccgagttca caaagtccat tgctaagttt tttgaccaca    240

gtgggacact ggtcatggat gcatatgagc ctgaaatatc caggctccat gacagtcttg    300

ccatagaaag aaaaataaag tagccaattc taaaagtagc cctctttctc ctggatcttg    360

ctgaattagt ggcttggggg gtgggggaga taaaaagaac ttaaaatggg taaagtaaga    420

aatgttaaaa agtccctgtt ttgtcctgaa attttagtct attctgggta aataggattt    480

tctgacacag atatgagaag ttgtagctct gatgtctagc tgtagtctcc ttgatctgct    540

gattgcatta ttttaatttg cttttctggg aaagcagttt tgctaaaagc tgtacagact    600

ttttcttttg tacctagcag tactttatat agtatagctt tgggccatgt agcattttaa    660

gactcaattt taaaaaatta ttaatctgtt gctgactctt aattcctatt tcaatatgtg    720

tttccttgaa gaattcagga tacaacttct tgtgtatgac agctttcctt cacacactat    780

ttttgtgggt gtgtatatat ctgatttggg aagaatttaa aaaacacata gctttttaat    840

ttgtttgaaa cagactttct gcctgttaca tttttgcttt taaccaatta aagaagccaa    900

tggcatttta gttttatatt gtgttttcca ctagtatatc cctgttgatt tgtttgtgcc    960

ttttattaac tgccattttc taaaattttt ttcaataaaa ggaaggaaga tgtgaaaaaa   1020

atggagtcat agttttgatg gagagaacag agaaacaagt gttaacatct ttctactata   1080

ggtttttttc atttttaggc tattttactt gtcaaaggcc cctgagaacc tgtagctaag   1140

gaactcttag ctttccagtg ataataacaa taataacaac attctgtact tactttgtgc   1200

cagaaatgct ccaagtactt tacatgtgtt aataatgctc acagcaatcc taagaggcag   1260

gtgctgttat tatccccatt ttacacatga ggaaactgag atacaaaagt taaataattg   1320

tcacacagct agtgatagaa ctgggattca aacctgggga gtccggcttc agagtttgtg   1380

gtcctgcaga gacaaaacag ccgcttttcc agtattttcc cagtatggtc agagaagacc   1440

tgggtgcttg ccaagatcct ttgaccttta ggaatatttc cctacagcct tacaaaacat   1500

caattttggc tgagcctagt acccaacact atattcagtt tgtaagaaat taccattatc   1560

acatttcctg tttgtcttgg agaggttgtc ctatctcgca ccacatggta gggaattgtg   1620

aacaacactg gacagaaagt taaagccttg gattctgtac tcttcattcc tgtaaacctt   1680

gggtaagttt cggaattctc tgtgagcttc ttaaagtttt tgaaagcatg taaccggata   1740

agtgtatttt tacaatggag gagttacagt catcttggta tttgtgggag attggttcca   1800

ggatccccaa gcataccaaa atccaaggat gctcaagtcc cttatataaa atggtatagc   1860

atttgcatat aacctacaca catcctccca tatactttta atcacctctg gattacctat   1920

aatacctaat ataatgtaaa tgctatgtaa atagttatac tgcattggtt ttttaattta   1980

tattttttgt tattttttaa aatatatttt taatccatgg ttggttaaat ctgtagatat   2040

agagggccaa ctgtactgtt agacacaagg gtctcgaggc ttgcagatag agactgaata   2100

accctctcca tgatgatccc ttagagttcc cccactgtgc ctttttcttt acatgtgcat   2160

gcaaacatgt gtctccacat acattttttt taacaaaaat tgaattatgt tgatatatgt   2220

cctgtaattt gtgttttaaa cttaatatat cttaggcatt ttccctgtgt gtgtgtataa   2280

tgcagctatt aaaaatgagt ctgaggccag gca                                2313


<210>  2835
<211>  103
<212>  PRT
<213>  Homo sapiens

<400>  2835


Met Met Gly Ile Leu Thr Ile Tyr Thr Ser Tyr Lys Glu Lys Ser Ile 
1               5                   10                  15      


Phe Leu Val Ala His Arg Lys Asp Pro Thr Gly Met Asp Pro Asp Asp 
            20                  25                  30          


Ile Trp Gln Leu Ser Ser Ser Leu Lys Arg Phe Asp Asp Lys Tyr Thr 
        35                  40                  45              


Leu Lys Leu Thr Phe Ile Ser Gly Arg Thr Lys Gln Gln Arg Glu Ala 
    50                  55                  60                  


Glu Phe Thr Lys Ser Ile Ala Lys Phe Phe Asp His Ser Gly Thr Leu 
65                  70                  75                  80  


Val Met Asp Ala Tyr Glu Pro Glu Ile Ser Arg Leu His Asp Ser Leu 
                85                  90                  95      


Ala Ile Glu Arg Lys Ile Lys 
            100             

<210>  2836
<211>  1138
<212>  DNA
<213>  Homo sapiens

<400>  2836
gaaaactgtt aatagcacgt taatttagac ttttagaata tatccttggg tcaccttcga     60

cagttttatc aacctactct agaacttctg atccctctct ctctacagct ttaaggaaaa    120

aaagctcccc atctttgggg aagggaggaa tgcccctttt acagctccgt tcaatatagg    180

catccaaatc actatcctcc ttggccccat ggggacaggg aaatctgcac atagaggtgg    240

tcaaaaatgc caaataccat ggggcagatc tacaatagca tgcaggagag cagcgaaaaa    300

aaaggagccc tgagccctgg gggtgcttgt cagagccaac aggtatttga aggaagaggc    360

aacactgttc tggggcaagg agtcaaagtg ggattacttc ctagtaacaa ctgtctcctg    420

caggctagcc tcttccacct cctccttcca ccacctctca cacttctggc tgtggaaata    480

acatcatttc ttggctgtga tctccaacat acctatctta aactgcttgg tttgggtgcc    540

cataggggag aaaaagtacc tgaattcaac tggtagggtc tgttagctta caagtaggat    600

aaaattcaca gatgtgaaag ttgtggtaat gaaaaattgc atgggaaagg aaaattaaaa    660

tgacctgtgg atggagcctc taaacattta atgtactgct gttttatggc tttagcatca    720

aagtgtgttg ttaataccaa tatacattta attgaactag gaaagtttat aagtctccca    780

ttcagggact actgcagtat agagagatgt agtctaaaag aaacaacata caaccgcaag    840

aggaaaagaa ataaaagcac aggtttagtt gaaaacttag ttactcctgt agtactcagg    900

ccattttcca ttataaccag ctatgtggac tttgcagtca ccaaggtgaa atatcctgag    960

tactccaaga gtgaccttta aaaagatagg cacctcttag gctgctactg agctcttgag   1020

gaaacaacag cggccagagg agcttcctga aagcgtaact gattcattta tgggtgatag   1080

aattgctctt cctctttgtg ggccaaattg gagtcagtgc aatcactaat acatccca     1138


<210>  2837
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  2837


Met Pro Asn Thr Met Gly Gln Ile Tyr Asn Ser Met Gln Glu Ser Ser 
1               5                   10                  15      


Glu Lys Lys Gly Ala Leu Ser Pro Gly Gly Ala Cys Gln Ser Gln Gln 
            20                  25                  30          


Val Phe Glu Gly Arg Gly Asn Thr Val Leu Gly Gln Gly Val Lys Val 
        35                  40                  45              


Gly Leu Leu Pro Ser Asn Asn Cys Leu Leu Gln Ala Ser Leu Phe His 
    50                  55                  60                  


Leu Leu Leu Pro Pro Pro Leu Thr Leu Leu Ala Val Glu Ile Thr Ser 
65                  70                  75                  80  


Phe Leu Gly Cys Asp Leu Gln His Thr Tyr Leu Lys Leu Leu Gly Leu 
                85                  90                  95      


Gly Ala His Arg Gly Glu Lys Val Pro Glu Phe Asn Trp 
            100                 105                 

<210>  2838
<211>  3519
<212>  DNA
<213>  Homo sapiens

<400>  2838
tttcctttta ttggcgtttg taaaatttct tctttttaaa attgttatat tttagagaca     60

gggtctcgct ctgtcaccca ggctggagtg cagtggtgca atcacagctc accacagcct    120

ccaactcctg ggctcaaggc atcctcccac gtaggccttc caaagcgctg agattgtagg    180

cataagccac caggcccagc ctattacctt tacgttgtac ttagtcccag ataaaaaatg    240

accttagatc agtcctttcc tctttggctg gggagagggg ggcttaaatt ccggtactgt    300

gaaacagaag aatggactca gtgctatgtg acaaatctat gtatgtaaat gtgtgtatat    360

acacacacat aaattatata tatgaatata ttttcatttt catattttgc aaggagagta    420

gccaatgctc tggacctctg gtcctttttg tagggtaccc tctgaggccg ggaacctttg    480

ctcaactctc aggctgtcca gggaagcttt aggcggtgat accgagctac agaccaatat    540

aagagctcgg ggctgtggca ctgaagagag gaggcggccg ttgggaactg aggtgggccc    600

agggcttgag ctgagttggc gagggtggag gtggtgccgg tcccacgccg tggtggggac    660

cgagctgcgg gctggaggga ggggcagcgc cgagggggcg ggacggggag ggctcgcgga    720

gtaggccaac ggttggcccc aaccgccact gactacagcc tgcgcccgcc tcttttcgtt    780

gccgttacct gtttccggca gtcgacacgc tcttcgcttc tcggggcttg tctccgtgtc    840

ctccgtctca gttgtttctc cctctctatc ctcctctgtc tcagtctccc cagccttggg    900

gccggtgcct cttccgggct tcggcgaatg agacctgcgg acctgccccc gcgccccatg    960

gaagaatccc cggcgtccag ctctgccccg acagagacgg aggagccggg gtccagtgca   1020

gaggtcatgg aagaagtgac aacatgctcc ttcaacagcc ctctgttccg gcaggaagat   1080

gacagaggga ttacctaccg gatcccagcc ctgctctaca taccccccac ccacaccttc   1140

ctggcctttg cagagaagcg ttctacgagg agagatgagg atgctctcca cctggtgctg   1200

aggcgagggt tgaggattgg gcagttggta cagtgggggc ccctgaagcc actgatggaa   1260

gccacactac cggggcatcg gaccatgaac ccctgtcctg tatgggagca gaagagtggt   1320

tgtgtgttcc tgttcttcat ctgtgtgcgg ggccatgtca cagagcgtca acagattgtg   1380

tcaggcagga atgctgcccg cctttgcttc atctacagtc aggatgctgg atgttcatgg   1440

agtgaggtga gggacttgac tgaggaggtc attggctcag agctgaagca ctgggccaca   1500

tttgctgtgg gcccaggtca tggcatccag ctgcagtcag ggagactggt catccctgcg   1560

tatacctact acatcccttc ctggttcttt tgcttccagc taccatgtaa aaccaggcct   1620

cattctctga tgatctacag tgatgaccta ggggtcacat ggcaccatgg tagactcatt   1680

aggcccatgg ttacagtaga atgtgaagtg gcagaggtga ctgggagggc tggccaccct   1740

gtgctatatt gcagtgcccg gacaccaaac aggtgccggg cagaggcgct cagcactgac   1800

catggtgaag gctttcagag actggccctg agtcgacagc tctgtgagcc cccacatggt   1860

tgccaaggga gtgtggtaag tttccggccc ctggagatcc cacataggtg ccaggactct   1920

agcagcaaag atgcacccac cattcagcag agctctccag gcagttcact gaggctggag   1980

gaggaagctg gaacaccgtc agaatcatgg ctcttgtact cacacccaac cagtaggaaa   2040

cagagggttg acctaggtat ctatctcaac cagaccccct tggaggctgc ctgctggtcc   2100

cgcccctgga tcttgcactg tgggccctgt ggctactctg atctggctgc tctggaggag   2160

gagggcttgt ttgggtgttt gtttgaatgt gggaccaagc aagagtgtga gcagattgcc   2220

ttccgcctgt ttacacaccg ggagatcctg agtcacctgc agggggactg caccagccct   2280

ggtaggaacc caagccaatt caaaagcaat taattggctt aggacccaat ttccatagat   2340

gcaaatggca gttacagaca ggttaacaga agctactgaa gtctacagat aatcaaaaaa   2400

cttaatattc tgttccctac cttttttcac ttttcctcct ccaaagagca aaatgaaaat   2460

tttgccttag ctactgcagt ggaaagagca ctgaactagg agttggaaga caaggatgtg   2520

gtcctggctc tgccactggc ttgcttttgg accttggatg tgtcacctga actctctgga   2580

cctcaggttt ccatctgtaa aatgagagta ttggttctaa gatttctcat cttctcatcc   2640

ctaggacaag catagtgcct gcatgcttca tgatcagtaa gtcctggctg cataaaggac   2700

tctgatgtca aaatggaaac caggggactt accttttcac atgacttacc cctcatccga   2760

gtgtgaggtt acaagcaggt gtcatggcag gaaggaagac cagatctgta tgatttgttc   2820

catttttaat aacaaaaata tccacaccct tttaataatg ctcagttctg taggctctct   2880

atcctagagg aattgagcaa aacagaagaa tcatgaagtc tcctaccttc tacagccttg   2940

tagttctgct taccttctct tcctcatcca gaaagcatca ttttctaggg agaacaatga   3000

gaatctcaat gccagtagta ctggataata gtgcgtattg cttctggtgg cattaccctg   3060

atgatgggct gaagttcatt tattagggtg gttcctgatg ggaaaaggac atggattagg   3120

actttaaaac actggacaga atttcccaca gtctttgccc tcaaggagtt caccagttta   3180

tggggctaga agagcgagaa aattcaagaa aataaatgta gctggtggga gactttgtag   3240

atgttgggct atatgttggg gtgatggtag ctcctgatgt aattttctta gttgcatctt   3300

caatatgcct ggagtcgtct gtccaaggct tgtccaggct tctgggtttc tctcaagttt   3360

gtttttctca ggatattgtc ctggcccagc tactccttta cctgtgagaa gatcttcacc   3420

attaggaaga tctctagacc cccagatctc agaatcaggc ctatttgtgt aggcccatgg   3480

aaatcactac ttgtgaagta gagatgcctt tttgtctaa                          3519


<210>  2839
<211>  461
<212>  PRT
<213>  Homo sapiens

<400>  2839


Met Arg Pro Ala Asp Leu Pro Pro Arg Pro Met Glu Glu Ser Pro Ala 
1               5                   10                  15      


Ser Ser Ser Ala Pro Thr Glu Thr Glu Glu Pro Gly Ser Ser Ala Glu 
            20                  25                  30          


Val Met Glu Glu Val Thr Thr Cys Ser Phe Asn Ser Pro Leu Phe Arg 
        35                  40                  45              


Gln Glu Asp Asp Arg Gly Ile Thr Tyr Arg Ile Pro Ala Leu Leu Tyr 
    50                  55                  60                  


Ile Pro Pro Thr His Thr Phe Leu Ala Phe Ala Glu Lys Arg Ser Thr 
65                  70                  75                  80  


Arg Arg Asp Glu Asp Ala Leu His Leu Val Leu Arg Arg Gly Leu Arg 
                85                  90                  95      


Ile Gly Gln Leu Val Gln Trp Gly Pro Leu Lys Pro Leu Met Glu Ala 
            100                 105                 110         


Thr Leu Pro Gly His Arg Thr Met Asn Pro Cys Pro Val Trp Glu Gln 
        115                 120                 125             


Lys Ser Gly Cys Val Phe Leu Phe Phe Ile Cys Val Arg Gly His Val 
    130                 135                 140                 


Thr Glu Arg Gln Gln Ile Val Ser Gly Arg Asn Ala Ala Arg Leu Cys 
145                 150                 155                 160 


Phe Ile Tyr Ser Gln Asp Ala Gly Cys Ser Trp Ser Glu Val Arg Asp 
                165                 170                 175     


Leu Thr Glu Glu Val Ile Gly Ser Glu Leu Lys His Trp Ala Thr Phe 
            180                 185                 190         


Ala Val Gly Pro Gly His Gly Ile Gln Leu Gln Ser Gly Arg Leu Val 
        195                 200                 205             


Ile Pro Ala Tyr Thr Tyr Tyr Ile Pro Ser Trp Phe Phe Cys Phe Gln 
    210                 215                 220                 


Leu Pro Cys Lys Thr Arg Pro His Ser Leu Met Ile Tyr Ser Asp Asp 
225                 230                 235                 240 


Leu Gly Val Thr Trp His His Gly Arg Leu Ile Arg Pro Met Val Thr 
                245                 250                 255     


Val Glu Cys Glu Val Ala Glu Val Thr Gly Arg Ala Gly His Pro Val 
            260                 265                 270         


Leu Tyr Cys Ser Ala Arg Thr Pro Asn Arg Cys Arg Ala Glu Ala Leu 
        275                 280                 285             


Ser Thr Asp His Gly Glu Gly Phe Gln Arg Leu Ala Leu Ser Arg Gln 
    290                 295                 300                 


Leu Cys Glu Pro Pro His Gly Cys Gln Gly Ser Val Val Ser Phe Arg 
305                 310                 315                 320 


Pro Leu Glu Ile Pro His Arg Cys Gln Asp Ser Ser Ser Lys Asp Ala 
                325                 330                 335     


Pro Thr Ile Gln Gln Ser Ser Pro Gly Ser Ser Leu Arg Leu Glu Glu 
            340                 345                 350         


Glu Ala Gly Thr Pro Ser Glu Ser Trp Leu Leu Tyr Ser His Pro Thr 
        355                 360                 365             


Ser Arg Lys Gln Arg Val Asp Leu Gly Ile Tyr Leu Asn Gln Thr Pro 
    370                 375                 380                 


Leu Glu Ala Ala Cys Trp Ser Arg Pro Trp Ile Leu His Cys Gly Pro 
385                 390                 395                 400 


Cys Gly Tyr Ser Asp Leu Ala Ala Leu Glu Glu Glu Gly Leu Phe Gly 
                405                 410                 415     


Cys Leu Phe Glu Cys Gly Thr Lys Gln Glu Cys Glu Gln Ile Ala Phe 
            420                 425                 430         


Arg Leu Phe Thr His Arg Glu Ile Leu Ser His Leu Gln Gly Asp Cys 
        435                 440                 445             


Thr Ser Pro Gly Arg Asn Pro Ser Gln Phe Lys Ser Asn 
    450                 455                 460     

<210>  2840
<211>  2689
<212>  DNA
<213>  Homo sapiens

<400>  2840
ataagagctc ggggctgtgg cactgaagag aggaggcggc cgttgggaac tgagtctccc     60

cagccttggg gccggtgcct cttccgggct tcggcgaatg agacctgcgg acctgccccc    120

gcgccccatg gaagaatccc cggcgtccag ctctgccccg acagagacgg aggagccggg    180

gtccagtgca gaggtcatgg aagaagtgac aacatgctcc ttcaacagcc ctctgttccg    240

gcaggaagat gacagaggga ttacctaccg gatcccagcc ctgctctaca taccccccac    300

ccacaccttc ctggcctttg cagagaagcg ttctacgagg agagatgagg atgctctcca    360

cctggtgctg aggcgagggt tgaggattgg gcagttggta cagtgggggc ccctgaagcc    420

actgatggaa gccacactac cggggcatcg gaccatgaac ccctgtcctg tatgggagca    480

gaagagtggt tgtgtgttcc tgttcttcat ctgtgtgcgg ggccatgtca cagagcgtca    540

acagattgtg tcaggcagga atgctgcccg cctttgcttc atctacagtc aggatgctgg    600

atgttcatgg agtgaggtga gggacttgac tgaggaggtc attggctcag agctgaagca    660

ctgggccaca tttgctgtgg gcccaggtca tggcatccag ctgcagtcag ggagactggt    720

catccctgcg tatacctact acatcccttc ctggttcttt tgcttccagc taccatgtaa    780

aaccaggcct cattctctga tgatctacag tgatgaccta ggggtcacat ggcaccatgg    840

tagactcatt aggcccatgg ttacagtaga atgtgaagtg gcagaggtga ctgggagggc    900

tggccaccct gtgctatatt gcagtgcccg gacaccaaac aggtgccggg cagaggcgct    960

cagcactgac catggtgaag gctttcagag actggccctg agtcgacagc tctgtgagcc   1020

cccacatggt tgccaaggga gtgtggtaag tttccggccc ctggagatcc cacataggtg   1080

ccaggactct agcagcaaag atgcacccac cattcagcag agctctccag gcagttcact   1140

gaggctggag gaggaagctg gaacaccgtc agaatcatgg ctcttgtact cacacccaac   1200

cagtaggaaa cagagggttg acctaggtat ctatctcaac cagaccccct tggaggctgc   1260

ctgctggtcc cgcccctgga tcttgcactg tgggccctgt ggctactctg atctggctgc   1320

tctggaggag gagggcttgt ttgggtgttt gtttgaatgt gggaccaagc aagagtgtga   1380

gcagattgcc ttccgcctgt ttacacaccg ggagatcctg agtcacctgc agggggactg   1440

caccagccct ggtaggaacc caagccaatt caaaagcaat taattggctt aggacccaat   1500

ttccatagat gcaaatggca gttacagaca ggttaacaga agctactgaa gtctacagat   1560

aatcaaaaaa cttaatattc tgttccctac cttttttcac ttttcctcct ccaaagagca   1620

aaatgaaaat tttgccttag ctactgcagt ggaaagagca ctgaactagg agttggaaga   1680

caaggatgtg gtcctggctc tgccactggc ttgcttttgg accttggatg tgtcacctga   1740

actctctgga cctcaggttt ccatctgtaa aatgagagta ttggttctaa gatttctcat   1800

cttctcatcc ctaggacaag catagtgcct gcatgcttca tgatcagtaa gtcctggctg   1860

cataaaggac tctgatgtca aaatggaaac caggggactt accttttcac atgacttacc   1920

cctcatccga gtgtgaggtt acaagcaggt gtcatggcag gaaggaagac cagatctgta   1980

tgatttgttc catttttaat aacaaaaata tccacaccct tttaataatg ctcagttctg   2040

taggctctct atcctagagg aattgagcaa aacagaagaa tcatgaagtc tcctaccttc   2100

tacagccttg tagttctgct taccttctct tcctcatcca gaaagcatca ttttctaggg   2160

agaacaatga gaatctcaat gccagtagta ctggataata gtgcgtattg cttctggtgg   2220

cattaccctg atgatgggct gaagttcatt tattagggtg gttcctgatg ggaaaaggac   2280

atggattagg actttaaaac actggacaga atttcccaca gtctttgccc tcaaggagtt   2340

caccagttta tggggctaga agagcgagaa aattcaagaa aataaatgta gctggtggga   2400

gactttgtag atgttgggct atatgttggg gtgatggtag ctcctgatgt aattttctta   2460

gttgcatctt caatatgcct ggagtcgtct gtccaaggct tgtccaggct tctgggtttc   2520

tctcaagttt gtttttctca ggatattgtc ctggcccagc tactccttta cctgtgagaa   2580

gatcttcacc attaggaaga tctctagacc cccagatctc agaatcaggc ctatttgtgt   2640

aggcccatgg aaatcactac ttgtgaagta gagatgcctt tttgtctaa               2689


<210>  2841
<211>  461
<212>  PRT
<213>  Homo sapiens

<400>  2841


Met Arg Pro Ala Asp Leu Pro Pro Arg Pro Met Glu Glu Ser Pro Ala 
1               5                   10                  15      


Ser Ser Ser Ala Pro Thr Glu Thr Glu Glu Pro Gly Ser Ser Ala Glu 
            20                  25                  30          


Val Met Glu Glu Val Thr Thr Cys Ser Phe Asn Ser Pro Leu Phe Arg 
        35                  40                  45              


Gln Glu Asp Asp Arg Gly Ile Thr Tyr Arg Ile Pro Ala Leu Leu Tyr 
    50                  55                  60                  


Ile Pro Pro Thr His Thr Phe Leu Ala Phe Ala Glu Lys Arg Ser Thr 
65                  70                  75                  80  


Arg Arg Asp Glu Asp Ala Leu His Leu Val Leu Arg Arg Gly Leu Arg 
                85                  90                  95      


Ile Gly Gln Leu Val Gln Trp Gly Pro Leu Lys Pro Leu Met Glu Ala 
            100                 105                 110         


Thr Leu Pro Gly His Arg Thr Met Asn Pro Cys Pro Val Trp Glu Gln 
        115                 120                 125             


Lys Ser Gly Cys Val Phe Leu Phe Phe Ile Cys Val Arg Gly His Val 
    130                 135                 140                 


Thr Glu Arg Gln Gln Ile Val Ser Gly Arg Asn Ala Ala Arg Leu Cys 
145                 150                 155                 160 


Phe Ile Tyr Ser Gln Asp Ala Gly Cys Ser Trp Ser Glu Val Arg Asp 
                165                 170                 175     


Leu Thr Glu Glu Val Ile Gly Ser Glu Leu Lys His Trp Ala Thr Phe 
            180                 185                 190         


Ala Val Gly Pro Gly His Gly Ile Gln Leu Gln Ser Gly Arg Leu Val 
        195                 200                 205             


Ile Pro Ala Tyr Thr Tyr Tyr Ile Pro Ser Trp Phe Phe Cys Phe Gln 
    210                 215                 220                 


Leu Pro Cys Lys Thr Arg Pro His Ser Leu Met Ile Tyr Ser Asp Asp 
225                 230                 235                 240 


Leu Gly Val Thr Trp His His Gly Arg Leu Ile Arg Pro Met Val Thr 
                245                 250                 255     


Val Glu Cys Glu Val Ala Glu Val Thr Gly Arg Ala Gly His Pro Val 
            260                 265                 270         


Leu Tyr Cys Ser Ala Arg Thr Pro Asn Arg Cys Arg Ala Glu Ala Leu 
        275                 280                 285             


Ser Thr Asp His Gly Glu Gly Phe Gln Arg Leu Ala Leu Ser Arg Gln 
    290                 295                 300                 


Leu Cys Glu Pro Pro His Gly Cys Gln Gly Ser Val Val Ser Phe Arg 
305                 310                 315                 320 


Pro Leu Glu Ile Pro His Arg Cys Gln Asp Ser Ser Ser Lys Asp Ala 
                325                 330                 335     


Pro Thr Ile Gln Gln Ser Ser Pro Gly Ser Ser Leu Arg Leu Glu Glu 
            340                 345                 350         


Glu Ala Gly Thr Pro Ser Glu Ser Trp Leu Leu Tyr Ser His Pro Thr 
        355                 360                 365             


Ser Arg Lys Gln Arg Val Asp Leu Gly Ile Tyr Leu Asn Gln Thr Pro 
    370                 375                 380                 


Leu Glu Ala Ala Cys Trp Ser Arg Pro Trp Ile Leu His Cys Gly Pro 
385                 390                 395                 400 


Cys Gly Tyr Ser Asp Leu Ala Ala Leu Glu Glu Glu Gly Leu Phe Gly 
                405                 410                 415     


Cys Leu Phe Glu Cys Gly Thr Lys Gln Glu Cys Glu Gln Ile Ala Phe 
            420                 425                 430         


Arg Leu Phe Thr His Arg Glu Ile Leu Ser His Leu Gln Gly Asp Cys 
        435                 440                 445             


Thr Ser Pro Gly Arg Asn Pro Ser Gln Phe Lys Ser Asn 
    450                 455                 460     

<210>  2842
<211>  581
<212>  DNA
<213>  Homo sapiens

<400>  2842
agagaggagg cggccgttgg gaactgagtc tccccagcct tggggccggt gcctcttccg     60

ggcttcggcg aatgagacct gcggacctgc ccccgcgccc catggaagaa tccccggcgt    120

ccagctctgc cccgacagag acggaggagc cggggtccag tgcagtgggg gcccctgaag    180

ccactgatgg aagccacact accggggcat cggaccatga acccctgtcc tgtatgggag    240

cagaagagtg gttgtgtgtt cctgttcttc atctgtgtgc ggggccatgt cacagagcgt    300

caacagattg tgtcaggcag gaatgctgcc cgcctttgct tcatctacag tcaggatgct    360

ggatgttcat ggagtgagag aaccctgact aatacagtaa attggtacca gtagagtggg    420

gcattgccga aaagataccc aaaaatgtgg aaactacttt ggaacttggt aacaggcaga    480

agttggaaca gtttggaggg ctcagaagaa gagagaaaaa tgtggaaaag tttggaactc    540

cctagagact tgttgaatgg ctttgacaaa aatgctgata a                        581


<210>  2843
<211>  101
<212>  PRT
<213>  Homo sapiens

<400>  2843


Met Arg Pro Ala Asp Leu Pro Pro Arg Pro Met Glu Glu Ser Pro Ala 
1               5                   10                  15      


Ser Ser Ser Ala Pro Thr Glu Thr Glu Glu Pro Gly Ser Ser Ala Val 
            20                  25                  30          


Gly Ala Pro Glu Ala Thr Asp Gly Ser His Thr Thr Gly Ala Ser Asp 
        35                  40                  45              


His Glu Pro Leu Ser Cys Met Gly Ala Glu Glu Trp Leu Cys Val Pro 
    50                  55                  60                  


Val Leu His Leu Cys Ala Gly Pro Cys His Arg Ala Ser Thr Asp Cys 
65                  70                  75                  80  


Val Arg Gln Glu Cys Cys Pro Pro Leu Leu His Leu Gln Ser Gly Cys 
                85                  90                  95      


Trp Met Phe Met Glu 
            100     

<210>  2844
<211>  425
<212>  DNA
<213>  Homo sapiens

<400>  2844
tttccggcag tcgacacgct cttcgcttct cggggcttgt ctccgtgtcc tccgtctcag     60

ttgtttctcc ctctctatcc tcctctgtct cagtctcccc agccttgggg ccggtgcctc    120

ttccgggctt cggcgaatga gacctgcgga cctgcccccg cgccccatgg aagaatcccc    180

ggcgtccagc tctgccccga cagagacgga ggagccgggg tccagtgcag cacctgattt    240

gtgtgaaacg ttttgggtgg caatgccaga atcaccatct atattacttc tgtcatcaac    300

acgatcagca taattacaaa aattaatggc tctaattgtt atagtgataa taaagcataa    360

atgaaattgt gaggacatca aaatttataa ttaaagacac ctattaaaac agcagtttaa    420

aattt                                                                425


<210>  2845
<211>  58
<212>  PRT
<213>  Homo sapiens

<400>  2845


Met Arg Pro Ala Asp Leu Pro Pro Arg Pro Met Glu Glu Ser Pro Ala 
1               5                   10                  15      


Ser Ser Ser Ala Pro Thr Glu Thr Glu Glu Pro Gly Ser Ser Ala Ala 
            20                  25                  30          


Pro Asp Leu Cys Glu Thr Phe Trp Val Ala Met Pro Glu Ser Pro Ser 
        35                  40                  45              


Ile Leu Leu Leu Ser Ser Thr Arg Ser Ala 
    50                  55              

<210>  2846
<211>  583
<212>  DNA
<213>  Homo sapiens

<400>  2846
agtcgacacg ctcttcgctt ctcggggctt gtctccgtgt cctccgtctc agttgtttct     60

ccctctctat cctcctctgt ctcagtctcc ccagccttgg ggccggtgcc tcttccgggc    120

ttcggcgaat gagacctgcg gacctgcccc cgcgccccat ggaagaatcc ccggcgtcca    180

gctctgcccc gacagagacg gaggagccgg ggtccagtgc agtgggggcc cctgaagcca    240

ctgatggaag ccacactacc ggggcatcgg accatgaacc cctgtcctgt atgggagcag    300

aagagtggtt gtgtgttcct gttcttcatc tgtgtgcggg gccatgtcac agagcgtcaa    360

cagattgtgt caggcaggaa tgctgcccgc ctttgcttca tctacagtca ggatgctgga    420

tgttcatgga gtgaggtgag ggacttgact gaggaggtca ttggctcaga gctgaagcac    480

tgggccacat ttgctgtggg cccaggtcat ggcatccagc tgcagtcagg gagactggtc    540

atccctgcgt atacctacta catcccttcc tggttctttt gct                      583


<210>  2847
<211>  101
<212>  PRT
<213>  Homo sapiens

<400>  2847


Met Arg Pro Ala Asp Leu Pro Pro Arg Pro Met Glu Glu Ser Pro Ala 
1               5                   10                  15      


Ser Ser Ser Ala Pro Thr Glu Thr Glu Glu Pro Gly Ser Ser Ala Val 
            20                  25                  30          


Gly Ala Pro Glu Ala Thr Asp Gly Ser His Thr Thr Gly Ala Ser Asp 
        35                  40                  45              


His Glu Pro Leu Ser Cys Met Gly Ala Glu Glu Trp Leu Cys Val Pro 
    50                  55                  60                  


Val Leu His Leu Cys Ala Gly Pro Cys His Arg Ala Ser Thr Asp Cys 
65                  70                  75                  80  


Val Arg Gln Glu Cys Cys Pro Pro Leu Leu His Leu Gln Ser Gly Cys 
                85                  90                  95      


Trp Met Phe Met Glu 
            100     

<210>  2848
<211>  580
<212>  DNA
<213>  Homo sapiens

<400>  2848
ctcttcgctt ctcggggctt gtctccgtgt cctccgtctc agttgtttct ccctctctat     60

cctcctctgt ctcagtctcc ccagccttgg ggccggtgcc tcttccgggc ttcggcgaat    120

gagacctgcg gacctgcccc cgcgccccat ggaagaatcc ccggcgtcca gctctgcccc    180

gacagagacg gaggagccgg ggtccagtgc agaggtcatg gaagaagtga caacatgctc    240

cttcaacagc cctctgttcc ggcaggaaga tgacagaggg attacctacc ggatcccagc    300

cctgctctac atacccccca cccacacctt cctggccttt gcagagaagc gttctacgag    360

gagagatgag gatgctctcc acctggtgct gaggcgaggg ttgaggattg ggcagttggt    420

acagatgggg ttttgccatg ttgcccagac tggtctcaaa ctcctggact caagctattc    480

taaagtgctg ggattacagc atgagccact gtgcctggcc atttgggggc ccctgaagcc    540

actgatggaa gccacactac cggggcatcg gaccatgaac                          580


<210>  2849
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  2849


Met Arg Pro Ala Asp Leu Pro Pro Arg Pro Met Glu Glu Ser Pro Ala 
1               5                   10                  15      


Ser Ser Ser Ala Pro Thr Glu Thr Glu Glu Pro Gly Ser Ser Ala Glu 
            20                  25                  30          


Val Met Glu Glu Val Thr Thr Cys Ser Phe Asn Ser Pro Leu Phe Arg 
        35                  40                  45              


Gln Glu Asp Asp Arg Gly Ile Thr Tyr Arg Ile Pro Ala Leu Leu Tyr 
    50                  55                  60                  


Ile Pro Pro Thr His Thr Phe Leu Ala Phe Ala Glu Lys Arg Ser Thr 
65                  70                  75                  80  


Arg Arg Asp Glu Asp Ala Leu His Leu Val Leu Arg Arg Gly Leu Arg 
                85                  90                  95      


Ile Gly Gln Leu Val Gln Met Gly Phe Cys His Val Ala Gln Thr Gly 
            100                 105                 110         


Leu Lys Leu Leu Asp Ser Ser Tyr Ser Lys Val Leu Gly Leu Gln His 
        115                 120                 125             


Glu Pro Leu Cys Leu Ala Ile Trp Gly Pro Leu Lys Pro Leu Met Glu 
    130                 135                 140                 


Ala Thr Leu Pro Gly His Arg Thr Met 
145                 150             

<210>  2850
<211>  746
<212>  DNA
<213>  Homo sapiens

<400>  2850
tcttcgcttc tcggggcttg tctccgtgtc ctccgtctca gttgtttctc cctctctatc     60

ctcctctgtc tcagtctccc cagccttggg gccggtgcct cttccgggct tcggcgaatg    120

agacctgcgg acctgccccc gcgccccatg gaagaatccc cggcgtccag ctctgccccg    180

acagagacgg aggagccggg gtccagtgca gaggtcatgg aagaagtgac aacatgctcc    240

ttcaacagcc ctctgttccg gcaggaagat gacagaggga ttacctaccg gatcccagcc    300

ctgctctaca taccccccac ccacaccttc ctggcctttg cagagaagcg ttctacgagg    360

agagatgagg atgctctcca cctggtgctg aggcgagggt tgaggattgg gcagttggta    420

caggtgactc ttcatcccag atctgagtct gggcctcagt ttctcttcac aaagctcaga    480

gctcttcagg atctgtgcct tttctcatca gtacaggaaa gccctgtgtg gggagcagag    540

gcagaaaaaa cagcaaaaac aatggctctc actgagtgct tattgtgtgc caggggcaca    600

ttgggtcctc acagccattc tgtgtcgtag gtactgtttt cagtcatatt ttacagacaa    660

ggaaactgag actcagagag gttgccattt gctcaaggtt atacagctat aataaagcag    720

tagaagctgg tttcaaactc agtcgc                                         746


<210>  2851
<211>  170
<212>  PRT
<213>  Homo sapiens

<400>  2851


Met Arg Pro Ala Asp Leu Pro Pro Arg Pro Met Glu Glu Ser Pro Ala 
1               5                   10                  15      


Ser Ser Ser Ala Pro Thr Glu Thr Glu Glu Pro Gly Ser Ser Ala Glu 
            20                  25                  30          


Val Met Glu Glu Val Thr Thr Cys Ser Phe Asn Ser Pro Leu Phe Arg 
        35                  40                  45              


Gln Glu Asp Asp Arg Gly Ile Thr Tyr Arg Ile Pro Ala Leu Leu Tyr 
    50                  55                  60                  


Ile Pro Pro Thr His Thr Phe Leu Ala Phe Ala Glu Lys Arg Ser Thr 
65                  70                  75                  80  


Arg Arg Asp Glu Asp Ala Leu His Leu Val Leu Arg Arg Gly Leu Arg 
                85                  90                  95      


Ile Gly Gln Leu Val Gln Val Thr Leu His Pro Arg Ser Glu Ser Gly 
            100                 105                 110         


Pro Gln Phe Leu Phe Thr Lys Leu Arg Ala Leu Gln Asp Leu Cys Leu 
        115                 120                 125             


Phe Ser Ser Val Gln Glu Ser Pro Val Trp Gly Ala Glu Ala Glu Lys 
    130                 135                 140                 


Thr Ala Lys Thr Met Ala Leu Thr Glu Cys Leu Leu Cys Ala Arg Gly 
145                 150                 155                 160 


Thr Leu Gly Pro His Ser His Ser Val Ser 
                165                 170 

<210>  2852
<211>  882
<212>  DNA
<213>  Homo sapiens

<400>  2852
cacttagctt gtggagaagg tcctaactca acactgcaac tttaagctgg cttaacttgt     60

ccaagttcca gatgaccaac aaagacagct atagacactc taactctgtg ccaattaccc    120

aaggccttca gggccctggg acctattcca tgatagtggt accctaactg aacccatttc    180

agccactcag attgatagga tggaaaagac agggcaggtg gtagcagctg tgaagaaaag    240

aggaaagcag aagggtggcc tataatctac aggcatgtag agaggactac ataggcctct    300

gttctttgcc ctcaggagcc cccttcctgt cccttggact cagaatggat ccttccagca    360

cacatggccc aacactgaga gtgcaggaag catgggtagg ggcctcctgc tgctggtatg    420

tacccaggcc agcctcctgc cgacacagcc tactggctgg gttcatgttc ttactattca    480

cctcaggcca ttgtctgggt gcttaatttg acttgtttcc cctggtcacc agtctcccct    540

ccgatattca caggacatca agcagcttca gccacgggta agaggctttt caccctgcct    600

gttgggtagc ccagaggacc cacaaaggtc aacctgagtc tccacagcct cctccccagg    660

gcagtaggaa ttgatatctc attcactggt attttccctc tgtccctaat tgggttttct    720

atagttacta gttttccagg cctccaaggg agattctgag gcttgatgtg ttctgactgt    780

gtcttggctt tgtgatgctg agtgccagaa atactctgta ctataaaaac taccatcgtt    840

ctttgaaaca acaaagagga ataaagaact taattctggt ga                       882


<210>  2853
<211>  63
<212>  PRT
<213>  Homo sapiens

<400>  2853


Met Tyr Pro Gly Gln Pro Pro Ala Asp Thr Ala Tyr Trp Leu Gly Ser 
1               5                   10                  15      


Cys Ser Tyr Tyr Ser Pro Gln Ala Ile Val Trp Val Leu Asn Leu Thr 
            20                  25                  30          


Cys Phe Pro Trp Ser Pro Val Ser Pro Pro Ile Phe Thr Gly His Gln 
        35                  40                  45              


Ala Ala Ser Ala Thr Gly Lys Arg Leu Phe Thr Leu Pro Val Gly 
    50                  55                  60              

<210>  2854
<211>  963
<212>  DNA
<213>  Homo sapiens

<400>  2854
atggatgcca cagcctgtaa tgaatcagtg gatggctcac ccgtcttcta tctattgggc     60

atcccctctc tgccagagac cttcttcctc cctgtgtttt ttattttcct cctcttctac    120

cttctcatcc tgatgggtaa tgccctgatc ctggtggccg tggtggcaga gcccagcctc    180

cacaagccca tgtacttctt tctgatcaat ctctccacct tggacatcct tttcaccaca    240

accactgtcc ccaagatgct gtccttattc ttgcttgggg accgcttcct cagcttttct    300

tcctgcttac tgcagatgta cctcttccaa agttttacat gttcagaagc cttcatcctg    360

gtggtcatgg cctatgaccg ctatgtggct atctgccacc cactgcacta ccctgtcctc    420

atgaacccac agaccaatgc taccttggca gccagtgcct ggctaactgc cctcctcctg    480

cccatcccag cagtagtaag gacctcccag atggcatata acagcattgc ctacatctac    540

cactgcttct gtgatcatct ggctgtggtc caggcctcct gctctgacac caccccccag    600

accctcatgg gcttctgcat cgccatggtg gtgtccttcc tcccccttct cctggtgctt    660

ctctcctatg tccacatcct ggcctcagtg cttcgcatca gttccctaga aggacgggca    720

aaagccttct ccacctgcag ctcccacctt ctggtcgtgg gcacctacta ctcatctatt    780

gccatagcct acgtggccta cagggctgac ctgccccttg acttccatat catgggcaat    840

gtggtatatg ccattctcac accaattctc aaccccctca tttacacgct gagaaacagg    900

gatgtaaagg cagccatcac caaaatcatg tctcaagacc caggctgtga caggagcatt    960

tga                                                                  963


<210>  2855
<211>  320
<212>  PRT
<213>  Homo sapiens

<400>  2855


Met Asp Ala Thr Ala Cys Asn Glu Ser Val Asp Gly Ser Pro Val Phe 
1               5                   10                  15      


Tyr Leu Leu Gly Ile Pro Ser Leu Pro Glu Thr Phe Phe Leu Pro Val 
            20                  25                  30          


Phe Phe Ile Phe Leu Leu Phe Tyr Leu Leu Ile Leu Met Gly Asn Ala 
        35                  40                  45              


Leu Ile Leu Val Ala Val Val Ala Glu Pro Ser Leu His Lys Pro Met 
    50                  55                  60                  


Tyr Phe Phe Leu Ile Asn Leu Ser Thr Leu Asp Ile Leu Phe Thr Thr 
65                  70                  75                  80  


Thr Thr Val Pro Lys Met Leu Ser Leu Phe Leu Leu Gly Asp Arg Phe 
                85                  90                  95      


Leu Ser Phe Ser Ser Cys Leu Leu Gln Met Tyr Leu Phe Gln Ser Phe 
            100                 105                 110         


Thr Cys Ser Glu Ala Phe Ile Leu Val Val Met Ala Tyr Asp Arg Tyr 
        115                 120                 125             


Val Ala Ile Cys His Pro Leu His Tyr Pro Val Leu Met Asn Pro Gln 
    130                 135                 140                 


Thr Asn Ala Thr Leu Ala Ala Ser Ala Trp Leu Thr Ala Leu Leu Leu 
145                 150                 155                 160 


Pro Ile Pro Ala Val Val Arg Thr Ser Gln Met Ala Tyr Asn Ser Ile 
                165                 170                 175     


Ala Tyr Ile Tyr His Cys Phe Cys Asp His Leu Ala Val Val Gln Ala 
            180                 185                 190         


Ser Cys Ser Asp Thr Thr Pro Gln Thr Leu Met Gly Phe Cys Ile Ala 
        195                 200                 205             


Met Val Val Ser Phe Leu Pro Leu Leu Leu Val Leu Leu Ser Tyr Val 
    210                 215                 220                 


His Ile Leu Ala Ser Val Leu Arg Ile Ser Ser Leu Glu Gly Arg Ala 
225                 230                 235                 240 


Lys Ala Phe Ser Thr Cys Ser Ser His Leu Leu Val Val Gly Thr Tyr 
                245                 250                 255     


Tyr Ser Ser Ile Ala Ile Ala Tyr Val Ala Tyr Arg Ala Asp Leu Pro 
            260                 265                 270         


Leu Asp Phe His Ile Met Gly Asn Val Val Tyr Ala Ile Leu Thr Pro 
        275                 280                 285             


Ile Leu Asn Pro Leu Ile Tyr Thr Leu Arg Asn Arg Asp Val Lys Ala 
    290                 295                 300                 


Ala Ile Thr Lys Ile Met Ser Gln Asp Pro Gly Cys Asp Arg Ser Ile 
305                 310                 315                 320 

<210>  2856
<211>  3276
<212>  DNA
<213>  Homo sapiens

<400>  2856
atgccgaact tctgcgctgc ccccaactgc acgcggaaga gcacgcagtc cgacttggcc     60

ttcttcaggt tcccgcggga ccctgccaga tgccagaagt gggtggagaa ctgtaggaga    120

gcagacttag aagataaaac acctgatcag ctaaataaac attatcgatt atgtgccaaa    180

cattttgaga cctctatgat ctgtagaact agtccttata ggacagttct tcgagataat    240

gcaataccaa caatatttga tcttaccagt catttgaaca acccacatag tagacacaga    300

aaacgaataa aagaactgag tgaagatgaa atcaggacac tgaaacagaa aaaaattgat    360

gaaacttctg agcaggaaca aaaacataaa gaaaccaaca atagcaatgc tcagaacccc    420

agcgaagaag agggtgaagg gcaagatgag gacattttac ctctaaccct tgaagagaag    480

gaaaacaaag aatacctaaa atctctattt gaaatcttga ttctgatggg aaagcaaaac    540

atacctctgg atggacatga ggctgatgaa atcccagaag gtctctttac tccagataac    600

tttcaggcac tgctggagtg tcggataaat tctggtgaag aggttctgag aaagcggttt    660

gagacaacag cagttaacac gttgttttgt tcaaaaacac agcagaggca gatgctagag    720

atctgtgaga gctgtattcg agaagaaact ctcagggaag tgagagactc acacttcttt    780

tccattatca ctgacgatgt agtggacata gcaggggaag agcacctacc tgtgttggtg    840

aggtttgttg atgaatctca taacctaaga gaggaattta taggcttcct gccttatgaa    900

gccgatgcag aaattttggc tgtgaaattt cacactatga taactgagaa gtggggatta    960

aatatggagt attgtcgtgg ccaggcttac attgtctcta gtggattttc ttccaaaatg   1020

aaagttgttg cttctagact tttagagaaa tatccccaag ctatctacac actctgctct   1080

tcctgtgcct taaatatgtg gttggcaaaa tcagtacctg ttatgggagt atctgttgca   1140

ttaggaacaa ttgaggaagt ttgttctttt ttccatcgat caccacaact gcttttagaa   1200

cttgacaacg taatttctgt tctttttcag aacagtaaag aaaggggtaa agaactgaag   1260

gaaatctgcc attctcagtg gacaggcagg catgatgctt ttgaaatttt agtggaactc   1320

ctgcaagcac ttgttttatg tttagatggt ataaatagtg acacaaatat tagatggaat   1380

aactatatag ctggccgagc atttgtactc tgcagtgcag tgtcagattt tgatttcatt   1440

gttactattg ttgttcttaa aaatgtccta tcttttacaa gagcctttgg gaaaaacctc   1500

caggggcaaa cctctgatgt cttctttgcg gccggtagct tgactgcagt actgcattca   1560

ctcaacgaag tgatggaaaa tattgaagtt tatcatgaat tttggtttga ggaagccaca   1620

aatttggcaa ccaaacttga tattcaaatg aaactccctg ggaaattccg cagagctcac   1680

cagggtaact tggaatctca gctaacctct gagagttact ataaagaaac cctaagtgtc   1740

ccaacagtgg agcacattat tcaggaactt aaagatatat tctcagaaca gcacctcaaa   1800

gctcttaaat gcttatctct ggtaccctca gtcatgggac aactcaaatt caatacgtcg   1860

gaggaacacc atgctgacat gtatagaagt gacttaccca atcctgacac gctgtcagct   1920

gagcttcatt gttggagaat caaatggaaa cacaggggga aagatataga gcttccgtcc   1980

accatctatg aagccctcca cctgcctgac atcaagtttt ttcctaatgt gtatgcattg   2040

ctgaaggtcc tgtgtattct tcctgtgatg aaggttgaga atgagcggta tgaaaatgga   2100

cgaaagcgtc ttaaagcata tttgaggaac actttgacag accaaaggtc aagtaacttg   2160

gctttgctta acataaattt tgatataaaa cacgacctgg atttaatggt ggacacatat   2220

attaaactct atacaagtaa gtcagagctt cctacagata attccgaaac tgtggaaaat   2280

acctaagaga cttttaaaaa taggctttct tatatttgat atttggaaga aaaagccgta   2340

aggtgtatgt agaccactta atcactaaat atctttgcct ataggactcc attgaataca   2400

ttagccattg ataatctacc tgtttaaatg gcccctgttt gaactctcaa gctttgaaga   2460

cctacctgtt cttccagaag agaacgttga aagtgccatg tttccttttg cgtgatctct   2520

gttgatggca ctctggaatt gtttcagtta agtcatttta gacatagcat ttattatcac   2580

tgtggatctc tacttgttgg gtgttatgaa ttctttgaag aaatatattt tgaagaggtg   2640

tgggaggaag gaatacattt tataaaatgt tgtagtgaag cccacaattg acctttgact   2700

aataggagtt ttaagtatgt taaaaatcta tactggacag ttacaagaaa ttaccggaga   2760

aaagcttgtg agctcaccaa acaaggattt cagtgtagat tttgtctttc ttgaacttaa   2820

agaaacaaat gacaaagttt gaatggaaaa gcctgctgtt gttccacatc tcgttgctgt   2880

ttacattcct ttgtggagcc tacatcttcc taagcttttt agcaggtata tgttgaacac   2940

ttctgtttca tggttgagac agaatcagag gccatggata ctgacaactg atttgtctgt   3000

tttttttctc tgtctttttc catgactctt atatactgcc tcatcttgat ttataagcaa   3060

aacctggaaa acctacaaaa taagtgttgt ggtttatcta gaaaaatatg gaaaatattg   3120

ctgttatttt tggtgaagaa aatcaatttt gtatagttta tttcaatcta aataaaatgt   3180

gaattttgtt taaagcttag gcacattatt ttttgtgggg tcaaaacatt cttgtgtaaa   3240

ttctcttaaa catttgataa acagcttcac aattca                             3276


<210>  2857
<211>  761
<212>  PRT
<213>  Homo sapiens

<400>  2857


Met Pro Asn Phe Cys Ala Ala Pro Asn Cys Thr Arg Lys Ser Thr Gln 
1               5                   10                  15      


Ser Asp Leu Ala Phe Phe Arg Phe Pro Arg Asp Pro Ala Arg Cys Gln 
            20                  25                  30          


Lys Trp Val Glu Asn Cys Arg Arg Ala Asp Leu Glu Asp Lys Thr Pro 
        35                  40                  45              


Asp Gln Leu Asn Lys His Tyr Arg Leu Cys Ala Lys His Phe Glu Thr 
    50                  55                  60                  


Ser Met Ile Cys Arg Thr Ser Pro Tyr Arg Thr Val Leu Arg Asp Asn 
65                  70                  75                  80  


Ala Ile Pro Thr Ile Phe Asp Leu Thr Ser His Leu Asn Asn Pro His 
                85                  90                  95      


Ser Arg His Arg Lys Arg Ile Lys Glu Leu Ser Glu Asp Glu Ile Arg 
            100                 105                 110         


Thr Leu Lys Gln Lys Lys Ile Asp Glu Thr Ser Glu Gln Glu Gln Lys 
        115                 120                 125             


His Lys Glu Thr Asn Asn Ser Asn Ala Gln Asn Pro Ser Glu Glu Glu 
    130                 135                 140                 


Gly Glu Gly Gln Asp Glu Asp Ile Leu Pro Leu Thr Leu Glu Glu Lys 
145                 150                 155                 160 


Glu Asn Lys Glu Tyr Leu Lys Ser Leu Phe Glu Ile Leu Ile Leu Met 
                165                 170                 175     


Gly Lys Gln Asn Ile Pro Leu Asp Gly His Glu Ala Asp Glu Ile Pro 
            180                 185                 190         


Glu Gly Leu Phe Thr Pro Asp Asn Phe Gln Ala Leu Leu Glu Cys Arg 
        195                 200                 205             


Ile Asn Ser Gly Glu Glu Val Leu Arg Lys Arg Phe Glu Thr Thr Ala 
    210                 215                 220                 


Val Asn Thr Leu Phe Cys Ser Lys Thr Gln Gln Arg Gln Met Leu Glu 
225                 230                 235                 240 


Ile Cys Glu Ser Cys Ile Arg Glu Glu Thr Leu Arg Glu Val Arg Asp 
                245                 250                 255     


Ser His Phe Phe Ser Ile Ile Thr Asp Asp Val Val Asp Ile Ala Gly 
            260                 265                 270         


Glu Glu His Leu Pro Val Leu Val Arg Phe Val Asp Glu Ser His Asn 
        275                 280                 285             


Leu Arg Glu Glu Phe Ile Gly Phe Leu Pro Tyr Glu Ala Asp Ala Glu 
    290                 295                 300                 


Ile Leu Ala Val Lys Phe His Thr Met Ile Thr Glu Lys Trp Gly Leu 
305                 310                 315                 320 


Asn Met Glu Tyr Cys Arg Gly Gln Ala Tyr Ile Val Ser Ser Gly Phe 
                325                 330                 335     


Ser Ser Lys Met Lys Val Val Ala Ser Arg Leu Leu Glu Lys Tyr Pro 
            340                 345                 350         


Gln Ala Ile Tyr Thr Leu Cys Ser Ser Cys Ala Leu Asn Met Trp Leu 
        355                 360                 365             


Ala Lys Ser Val Pro Val Met Gly Val Ser Val Ala Leu Gly Thr Ile 
    370                 375                 380                 


Glu Glu Val Cys Ser Phe Phe His Arg Ser Pro Gln Leu Leu Leu Glu 
385                 390                 395                 400 


Leu Asp Asn Val Ile Ser Val Leu Phe Gln Asn Ser Lys Glu Arg Gly 
                405                 410                 415     


Lys Glu Leu Lys Glu Ile Cys His Ser Gln Trp Thr Gly Arg His Asp 
            420                 425                 430         


Ala Phe Glu Ile Leu Val Glu Leu Leu Gln Ala Leu Val Leu Cys Leu 
        435                 440                 445             


Asp Gly Ile Asn Ser Asp Thr Asn Ile Arg Trp Asn Asn Tyr Ile Ala 
    450                 455                 460                 


Gly Arg Ala Phe Val Leu Cys Ser Ala Val Ser Asp Phe Asp Phe Ile 
465                 470                 475                 480 


Val Thr Ile Val Val Leu Lys Asn Val Leu Ser Phe Thr Arg Ala Phe 
                485                 490                 495     


Gly Lys Asn Leu Gln Gly Gln Thr Ser Asp Val Phe Phe Ala Ala Gly 
            500                 505                 510         


Ser Leu Thr Ala Val Leu His Ser Leu Asn Glu Val Met Glu Asn Ile 
        515                 520                 525             


Glu Val Tyr His Glu Phe Trp Phe Glu Glu Ala Thr Asn Leu Ala Thr 
    530                 535                 540                 


Lys Leu Asp Ile Gln Met Lys Leu Pro Gly Lys Phe Arg Arg Ala His 
545                 550                 555                 560 


Gln Gly Asn Leu Glu Ser Gln Leu Thr Ser Glu Ser Tyr Tyr Lys Glu 
                565                 570                 575     


Thr Leu Ser Val Pro Thr Val Glu His Ile Ile Gln Glu Leu Lys Asp 
            580                 585                 590         


Ile Phe Ser Glu Gln His Leu Lys Ala Leu Lys Cys Leu Ser Leu Val 
        595                 600                 605             


Pro Ser Val Met Gly Gln Leu Lys Phe Asn Thr Ser Glu Glu His His 
    610                 615                 620                 


Ala Asp Met Tyr Arg Ser Asp Leu Pro Asn Pro Asp Thr Leu Ser Ala 
625                 630                 635                 640 


Glu Leu His Cys Trp Arg Ile Lys Trp Lys His Arg Gly Lys Asp Ile 
                645                 650                 655     


Glu Leu Pro Ser Thr Ile Tyr Glu Ala Leu His Leu Pro Asp Ile Lys 
            660                 665                 670         


Phe Phe Pro Asn Val Tyr Ala Leu Leu Lys Val Leu Cys Ile Leu Pro 
        675                 680                 685             


Val Met Lys Val Glu Asn Glu Arg Tyr Glu Asn Gly Arg Lys Arg Leu 
    690                 695                 700                 


Lys Ala Tyr Leu Arg Asn Thr Leu Thr Asp Gln Arg Ser Ser Asn Leu 
705                 710                 715                 720 


Ala Leu Leu Asn Ile Asn Phe Asp Ile Lys His Asp Leu Asp Leu Met 
                725                 730                 735     


Val Asp Thr Tyr Ile Lys Leu Tyr Thr Ser Lys Ser Glu Leu Pro Thr 
            740                 745                 750         


Asp Asn Ser Glu Thr Val Glu Asn Thr 
        755                 760     

<210>  2858
<211>  3464
<212>  DNA
<213>  Homo sapiens

<400>  2858
cgtctcgggc gggcgggagg tgcaccagcg gcggcggcgg cggtaaatcc tcccggccgc     60

tcacagcact gtggagccgc gtccccagcc cggcctcgga ccgcggcacc cctcctggcc    120

ctcgcggctt ctagcccgcc cgcccctccc ccgcgcgtcg gccctgccga gccggccggc    180

cggcctggct cccctccccg gccccgacgg gcgggcggac tgccctgagg aggcggggag    240

gggagggctg ggccggccgg cgggcgggcg acgatgccga acttctgcgc tgcccccaac    300

tgcacgcgga agagcacgca gtccgacttg gccttcttca ggttcccgcg ggaccctgcc    360

agatgccaga agtgggtgga gaactgtagg agagcagact tagaagataa aacacctgat    420

cagctaaata aacattatcg attatgtgcc aaacattttg agacctctat gatctgtaga    480

actagtcctt ataggacagt tcttcgagat aatgcaatac caacaatatt tgatcttacc    540

agtcatttga acaacccaca tagtagacac agaaaacgaa taaaagaact gagtgaagat    600

gaaatcagga cactgaaaca gaaaaaaatt gatgaaactt ctgagcagga acaaaaacat    660

aaagaaacca acaatagcaa tgctcagaac cccagcgaag aagagggtga agggcaagat    720

gaggacattt tacctctaac ccttgaagag aaggaaaaca aagaatacct aaaatctcta    780

tttgaaatct tgattctgat gggaaagcaa aacatacctc tggatggaca tgaggctgat    840

gaaatcccag aaggtctctt tactccagat aactttcagg cactgctgga gtgtcggata    900

aattctggtg aagaggttct gagaaagcgg tttgagacaa cagcagttaa cacgttgttt    960

tgttcaaaaa cacagcagag gcagatgcta gagatctgtg agagctgtat tcgagaagaa   1020

actctcaggg aagtgagaga ctcacacttc ttttccatta tcactgacga tgtagtggac   1080

atagcagggg aagagcacct acctgtgttg gtgaggtttg ttgatgaatc tcataaccta   1140

agagaggaat ttataggctt cctgccttat gaagccgatg cagaaatttt ggctgtgaaa   1200

tttcacacta tgataactga gaagtgggga ttaaatatgg agtattgtcg tggccaggct   1260

tacattgtct ctagtggatt ttcttccaaa atgaaagttg ttgcttctag acttttagag   1320

aaatatcccc aagctatcta cacactctgc tcttcctgtg ccttaaatat gtggttggca   1380

aaatcagtac ctgttatggg agtatctgtt gcattaggaa caattgagga agtttgttct   1440

tttttccatc gatcaccaca actgctttta gaacttgaca acgtaatttc tgttcttttt   1500

cagaacagta aagaaagggg taaagaactg aaggaaatct gccattctca gtggacaggc   1560

aggcatgatg cttttgaaat tttagtggaa ctcctgcaag cacttgtttt atgtttagat   1620

ggtataaata gtgacacaaa tattagatgg aataactata tagctggccg agcatttgta   1680

ctctgcagtg cagtgtcaga ttttgatttc attgttacta ttgttgttct taaaaatgtc   1740

ctatctttta caagagcctt tgggaaaaac ctccaggggc aaacctctga tgtcttcttt   1800

gcggccggta gcttgactgc agtactgcat tcactcaacg aagtgatgga aaatattgaa   1860

gtttatcatg aattttggtt tgaggaagcc acaaatttgg caaccaaact tgatattcaa   1920

atgaaactcc ctgggaaatt ccgcagagct caccagggta acttggaatc tcagctaacc   1980

tctgagagtt actataaaga aaccctaagt gtcccaacag tggagcacat tattcaggaa   2040

cttaaagata tattctcaga acagcacctc aaagctctta aatgcttatc tctggtaccc   2100

tcagtcatgg gacaactcaa attcaatacg tcggaggaac accatgctga catgtataga   2160

agtgacttac ccaatcctga cacgctgtca gctgagcttc attgttggag aatcaaatgg   2220

aaacacaggg ggaaagatat agagcttccg tccaccatct atgaagccct ccacctgcct   2280

gacatcaagt tttttcctaa tgtgtatgca ttgctgaagg tcctgtgtat tcttcctgtg   2340

atgaaggttg agaatgagcg gtatgaaaat ggacgaaagc gtcttaaagc atatttgagg   2400

aacactttga cagaccaaag gtcaagtaac ttggctttgc ttaacataaa ttttgatata   2460

aaacacgacc tggatttaat ggtggacaca tatattaaac tctatacaag taagtcagag   2520

cttcctacag ataattccga aactgtggaa aatacctaag agacttttaa aaataggctt   2580

tcttatattt gatatttgga agaaaaagcc gtaaggtgta tgtagaccac ttaatcacta   2640

aatatctttg cctataggac tccattgaat acattagcca ttgataatct acctgtttaa   2700

atggcccctg tttgaactct caagctttga agacctacct gttcttccag aagagaacgt   2760

tgaaagtgcc atgtttcctt ttgcgtgatc tctgttgatg gcactctgga attgtttcag   2820

ttaagtcatt ttagacatag catttattat cactgtggat ctctacttgt tgggtgttat   2880

gaattctttg aagaaatata ttttgaagag gtgtgggagg aaggaataca ttttataaaa   2940

tgttgtagtg aagcccacaa ttgacctttg actaatagga gttttaagta tgttaaaaat   3000

ctatactgga cagttacaag aaattaccgg agaaaagctt gtgagctcac caaacaagga   3060

tttcagtgta gattttgtct ttcttgaact taaagaaaca aatgacaaag tttgaatgga   3120

aaagcctgct gttgttccac atctcgttgc tgtttacatt cctttgtgga gcctacatct   3180

tcctaagctt tttagcaggt atatgttgaa cacttctgtt tcatggttga gacagaatca   3240

gaggccatgg atactgacaa ctgatttgtc tgtttttttt ctctgtcttt ttccatgact   3300

cttatatact gcctcatctt gatttataag caaaacctgg aaaacctaca aaataagtgt   3360

tgtggtttat ctagaaaaat atggaaaata ttgctgttat ttttggtgaa gaaaatcaat   3420

tttgtatagt ttatttcaat ctaaataaaa tgtgaatttt gttt                    3464


<210>  2859
<211>  761
<212>  PRT
<213>  Homo sapiens

<400>  2859


Met Pro Asn Phe Cys Ala Ala Pro Asn Cys Thr Arg Lys Ser Thr Gln 
1               5                   10                  15      


Ser Asp Leu Ala Phe Phe Arg Phe Pro Arg Asp Pro Ala Arg Cys Gln 
            20                  25                  30          


Lys Trp Val Glu Asn Cys Arg Arg Ala Asp Leu Glu Asp Lys Thr Pro 
        35                  40                  45              


Asp Gln Leu Asn Lys His Tyr Arg Leu Cys Ala Lys His Phe Glu Thr 
    50                  55                  60                  


Ser Met Ile Cys Arg Thr Ser Pro Tyr Arg Thr Val Leu Arg Asp Asn 
65                  70                  75                  80  


Ala Ile Pro Thr Ile Phe Asp Leu Thr Ser His Leu Asn Asn Pro His 
                85                  90                  95      


Ser Arg His Arg Lys Arg Ile Lys Glu Leu Ser Glu Asp Glu Ile Arg 
            100                 105                 110         


Thr Leu Lys Gln Lys Lys Ile Asp Glu Thr Ser Glu Gln Glu Gln Lys 
        115                 120                 125             


His Lys Glu Thr Asn Asn Ser Asn Ala Gln Asn Pro Ser Glu Glu Glu 
    130                 135                 140                 


Gly Glu Gly Gln Asp Glu Asp Ile Leu Pro Leu Thr Leu Glu Glu Lys 
145                 150                 155                 160 


Glu Asn Lys Glu Tyr Leu Lys Ser Leu Phe Glu Ile Leu Ile Leu Met 
                165                 170                 175     


Gly Lys Gln Asn Ile Pro Leu Asp Gly His Glu Ala Asp Glu Ile Pro 
            180                 185                 190         


Glu Gly Leu Phe Thr Pro Asp Asn Phe Gln Ala Leu Leu Glu Cys Arg 
        195                 200                 205             


Ile Asn Ser Gly Glu Glu Val Leu Arg Lys Arg Phe Glu Thr Thr Ala 
    210                 215                 220                 


Val Asn Thr Leu Phe Cys Ser Lys Thr Gln Gln Arg Gln Met Leu Glu 
225                 230                 235                 240 


Ile Cys Glu Ser Cys Ile Arg Glu Glu Thr Leu Arg Glu Val Arg Asp 
                245                 250                 255     


Ser His Phe Phe Ser Ile Ile Thr Asp Asp Val Val Asp Ile Ala Gly 
            260                 265                 270         


Glu Glu His Leu Pro Val Leu Val Arg Phe Val Asp Glu Ser His Asn 
        275                 280                 285             


Leu Arg Glu Glu Phe Ile Gly Phe Leu Pro Tyr Glu Ala Asp Ala Glu 
    290                 295                 300                 


Ile Leu Ala Val Lys Phe His Thr Met Ile Thr Glu Lys Trp Gly Leu 
305                 310                 315                 320 


Asn Met Glu Tyr Cys Arg Gly Gln Ala Tyr Ile Val Ser Ser Gly Phe 
                325                 330                 335     


Ser Ser Lys Met Lys Val Val Ala Ser Arg Leu Leu Glu Lys Tyr Pro 
            340                 345                 350         


Gln Ala Ile Tyr Thr Leu Cys Ser Ser Cys Ala Leu Asn Met Trp Leu 
        355                 360                 365             


Ala Lys Ser Val Pro Val Met Gly Val Ser Val Ala Leu Gly Thr Ile 
    370                 375                 380                 


Glu Glu Val Cys Ser Phe Phe His Arg Ser Pro Gln Leu Leu Leu Glu 
385                 390                 395                 400 


Leu Asp Asn Val Ile Ser Val Leu Phe Gln Asn Ser Lys Glu Arg Gly 
                405                 410                 415     


Lys Glu Leu Lys Glu Ile Cys His Ser Gln Trp Thr Gly Arg His Asp 
            420                 425                 430         


Ala Phe Glu Ile Leu Val Glu Leu Leu Gln Ala Leu Val Leu Cys Leu 
        435                 440                 445             


Asp Gly Ile Asn Ser Asp Thr Asn Ile Arg Trp Asn Asn Tyr Ile Ala 
    450                 455                 460                 


Gly Arg Ala Phe Val Leu Cys Ser Ala Val Ser Asp Phe Asp Phe Ile 
465                 470                 475                 480 


Val Thr Ile Val Val Leu Lys Asn Val Leu Ser Phe Thr Arg Ala Phe 
                485                 490                 495     


Gly Lys Asn Leu Gln Gly Gln Thr Ser Asp Val Phe Phe Ala Ala Gly 
            500                 505                 510         


Ser Leu Thr Ala Val Leu His Ser Leu Asn Glu Val Met Glu Asn Ile 
        515                 520                 525             


Glu Val Tyr His Glu Phe Trp Phe Glu Glu Ala Thr Asn Leu Ala Thr 
    530                 535                 540                 


Lys Leu Asp Ile Gln Met Lys Leu Pro Gly Lys Phe Arg Arg Ala His 
545                 550                 555                 560 


Gln Gly Asn Leu Glu Ser Gln Leu Thr Ser Glu Ser Tyr Tyr Lys Glu 
                565                 570                 575     


Thr Leu Ser Val Pro Thr Val Glu His Ile Ile Gln Glu Leu Lys Asp 
            580                 585                 590         


Ile Phe Ser Glu Gln His Leu Lys Ala Leu Lys Cys Leu Ser Leu Val 
        595                 600                 605             


Pro Ser Val Met Gly Gln Leu Lys Phe Asn Thr Ser Glu Glu His His 
    610                 615                 620                 


Ala Asp Met Tyr Arg Ser Asp Leu Pro Asn Pro Asp Thr Leu Ser Ala 
625                 630                 635                 640 


Glu Leu His Cys Trp Arg Ile Lys Trp Lys His Arg Gly Lys Asp Ile 
                645                 650                 655     


Glu Leu Pro Ser Thr Ile Tyr Glu Ala Leu His Leu Pro Asp Ile Lys 
            660                 665                 670         


Phe Phe Pro Asn Val Tyr Ala Leu Leu Lys Val Leu Cys Ile Leu Pro 
        675                 680                 685             


Val Met Lys Val Glu Asn Glu Arg Tyr Glu Asn Gly Arg Lys Arg Leu 
    690                 695                 700                 


Lys Ala Tyr Leu Arg Asn Thr Leu Thr Asp Gln Arg Ser Ser Asn Leu 
705                 710                 715                 720 


Ala Leu Leu Asn Ile Asn Phe Asp Ile Lys His Asp Leu Asp Leu Met 
                725                 730                 735     


Val Asp Thr Tyr Ile Lys Leu Tyr Thr Ser Lys Ser Glu Leu Pro Thr 
            740                 745                 750         


Asp Asn Ser Glu Thr Val Glu Asn Thr 
        755                 760     

<210>  2860
<211>  686
<212>  DNA
<213>  Homo sapiens

<400>  2860
cgtctcgggc gggcgggagg tgcaccagcg gcggcggcgg cggtaaatcc tcccggccgc     60

tcacagcact gtggagccgc gtccccagcc cggcctcgga ccgcggcacc cctcctggcc    120

ctcgcggctt ctagcccgcc cgcccctccc ccgcgcgtcg gccctgccga gccggccggc    180

cggcctggct cccctccccg gccccgacgg gcgggcggac tgccctgagg aggcggggag    240

gggagggctg ggccggccgg cgggcgggcg acgatgccga acttctgcgc tgcccccaac    300

tgcacgcgga agagcacgca gtccgacttg gccttcttca ggttcccgcg ggaccctgcc    360

agatgccaga agtgggtgga gaactgtagg agagcagact tagaagataa aacacctgat    420

cagctaaata aacattatcg attatgtgcc aaacattttg agacctctat gatctgtaga    480

actatacatt ttgcagaggc atcagaaaac taaagaatga ttgggttatt ttatttctca    540

aaattaattg aagcagatac ttgtgaagtc attgggagag tccttatagg acagttcttc    600

gagataatgc aataccaaca atatttgatc ttaccagtca tttgaacaac ccacatagta    660

gacacagaaa acgaataaaa gaactg                                         686


<210>  2861
<211>  79
<212>  PRT
<213>  Homo sapiens

<400>  2861


Met Pro Asn Phe Cys Ala Ala Pro Asn Cys Thr Arg Lys Ser Thr Gln 
1               5                   10                  15      


Ser Asp Leu Ala Phe Phe Arg Phe Pro Arg Asp Pro Ala Arg Cys Gln 
            20                  25                  30          


Lys Trp Val Glu Asn Cys Arg Arg Ala Asp Leu Glu Asp Lys Thr Pro 
        35                  40                  45              


Asp Gln Leu Asn Lys His Tyr Arg Leu Cys Ala Lys His Phe Glu Thr 
    50                  55                  60                  


Ser Met Ile Cys Arg Thr Ile His Phe Ala Glu Ala Ser Glu Asn 
65                  70                  75                  

<210>  2862
<211>  1147
<212>  DNA
<213>  Homo sapiens

<400>  2862
gccgcagtgc gactgcgcac agtctaatcc gcggggagag agaattgcgc atgcgcgcct     60

gtctcccggg acgctagagc aggcggttcc tgggctgctc cggtaggttt ggcgtgcgcg    120

ggtttctgca gatctagggc gagcttgcac gttacatcac cgatgcatct cttcttgctt    180

gcttaatttg ccaccactta ggcctttctt gcagaattcg ccatatactc cttaagggcc    240

gcggaatcgg agcgaccttg gtgactggca aactctcggc agatgtgcgt gcactggttt    300

gatgcagacg tggttgtagg cgatttaatt tttcccagct ttgcagcgac tgttggcttc    360

ccagaacgga tctccccagc ctcgactgga agctgaggga caaaaattca taaaagcaat    420

tactctttcc cggcgaggct tctagaagag caagaagagc gatatgatta cacctgcagc    480

cctataaaga ttgatctgtc cgtctttccc ttacagtcgt ggcctgttaa acgttcctgt    540

gttgttcagt gccagaatga gtgaccgcta tttagaacaa aggattagta tcaaattttg    600

cgtgaaattg aacaagtctg caagtgagac ccaccatctt ttaaaagaag cttatgggga    660

tgaagtcatg tcaagggcca gagtttttga ctggcacaaa aggtttaaag aaggacggga    720

agatgttcga gatgatgccc gaagtgggcg tccagtcacc caccgaacag atgacaatat    780

ccagaaggtc aaggacttgg tttgttcaaa caggcagtta accgtgagga tgatggctga    840

agagttaaat ttagacaaag aaactgttag gctcattttg aaagaaaact tgaacatgag    900

gaagatttct gcaaaagtta tttcgggtgt tttgaagggt gagcctaaac cacgaaaact    960

tgactttcgg tccgatcttt caaaggaaac taggaaaaat agctcatgtt tgaggaaaaa   1020

ggatgttttt cttctctact agcccaggac ctcctaaaag ccaagcccac atctgattgt   1080

tccatgttcc ctgcatccag aataaacctt gcgtggaact gctcaataaa tgtttgatag   1140

atgaatg                                                             1147


<210>  2863
<211>  161
<212>  PRT
<213>  Homo sapiens

<400>  2863


Met Ser Asp Arg Tyr Leu Glu Gln Arg Ile Ser Ile Lys Phe Cys Val 
1               5                   10                  15      


Lys Leu Asn Lys Ser Ala Ser Glu Thr His His Leu Leu Lys Glu Ala 
            20                  25                  30          


Tyr Gly Asp Glu Val Met Ser Arg Ala Arg Val Phe Asp Trp His Lys 
        35                  40                  45              


Arg Phe Lys Glu Gly Arg Glu Asp Val Arg Asp Asp Ala Arg Ser Gly 
    50                  55                  60                  


Arg Pro Val Thr His Arg Thr Asp Asp Asn Ile Gln Lys Val Lys Asp 
65                  70                  75                  80  


Leu Val Cys Ser Asn Arg Gln Leu Thr Val Arg Met Met Ala Glu Glu 
                85                  90                  95      


Leu Asn Leu Asp Lys Glu Thr Val Arg Leu Ile Leu Lys Glu Asn Leu 
            100                 105                 110         


Asn Met Arg Lys Ile Ser Ala Lys Val Ile Ser Gly Val Leu Lys Gly 
        115                 120                 125             


Glu Pro Lys Pro Arg Lys Leu Asp Phe Arg Ser Asp Leu Ser Lys Glu 
    130                 135                 140                 


Thr Arg Lys Asn Ser Ser Cys Leu Arg Lys Lys Asp Val Phe Leu Leu 
145                 150                 155                 160 


Tyr 
    

<210>  2864
<211>  1310
<212>  DNA
<213>  Homo sapiens

<400>  2864
gccgcagtgc gactgcgcac agtctaatcc gcggggagag agaattgcgc atgcgcgcct     60

gtctcccggg acgctagagc aggcggttcc tgggctgctc cggtaggttt ggcgtgcgcg    120

ggtttctgca gatctagggc gagcttgcac gttacatcac cgatgcatct cttcttgctt    180

gcttaatttg ccaccactta ggcctttctt gcagaattcg ccatatactc cttaagggcc    240

gcggaatcgg agcgaccttg gtgactggca aactctcggc agatgtgcgt gcactggttt    300

gatgcagacg tggttgtagg cgatttaatt tttcccagct ttgcagcgac tgttggcttc    360

ccagaacgga tctccccagc ctcgactgga agctgaggga caaaaattca taaaagcaat    420

tactctttcc cggcgaggct tctagaagag caagaagagc gatatgatta cacctgcagc    480

cctataaaga ttgatctgtc cgtctttccc ttacagtcgt ggcctgttaa acgttcctgt    540

gttgttcagt gccagaatga gtgaccgcta tttagaacaa aggattagta tcaaattttg    600

cgtgaaattg aacaagtctg caagtgagac ccaccatctt ttaaaagaag cttatgggga    660

tgaagtcatg tcaagggcca gagtttttga ctggcacaaa aggtttaaag aaggacggga    720

agatgttcga gatgatgccc gaagtgggcg tccagtcacc caccgaacag atgacaatat    780

ccagaaggtc aaggacttgg tttgttcaaa caggcagtta accgtgagga tgatggctga    840

agagttaaat ttagacaaag aaactgttag gctcattttg aaagaaaact tgaacatgag    900

gaagatttct gcaaaagtta tttcgggtgt tttgaagggt gagcctaaac cacgaaaact    960

tgactttcgg tccgatcttt caaaggaaac taggaaaaat agctcatgtt tgaggaaaaa   1020

gagacggaac ctcactatgt tgcccaggct ggtctcgaac tccttgtctc aagggatcct   1080

cccaccttgg cctcccaaag ctctgggatt atcagcatga gccaccatgc caagccaaaa   1140

ccaggagttc aatggtgtaa attccagtct gagtccacag gccgaagagc gaggagtgct   1200

gatgtacaag ggcaggagaa gatggatgtc acagctcaag aagcgagaac aaatttgccc   1260

ttctatcttt ttgttctatt caggtcctca atgaattgga tgatgtccat              1310


<210>  2865
<211>  187
<212>  PRT
<213>  Homo sapiens

<400>  2865


Met Ser Asp Arg Tyr Leu Glu Gln Arg Ile Ser Ile Lys Phe Cys Val 
1               5                   10                  15      


Lys Leu Asn Lys Ser Ala Ser Glu Thr His His Leu Leu Lys Glu Ala 
            20                  25                  30          


Tyr Gly Asp Glu Val Met Ser Arg Ala Arg Val Phe Asp Trp His Lys 
        35                  40                  45              


Arg Phe Lys Glu Gly Arg Glu Asp Val Arg Asp Asp Ala Arg Ser Gly 
    50                  55                  60                  


Arg Pro Val Thr His Arg Thr Asp Asp Asn Ile Gln Lys Val Lys Asp 
65                  70                  75                  80  


Leu Val Cys Ser Asn Arg Gln Leu Thr Val Arg Met Met Ala Glu Glu 
                85                  90                  95      


Leu Asn Leu Asp Lys Glu Thr Val Arg Leu Ile Leu Lys Glu Asn Leu 
            100                 105                 110         


Asn Met Arg Lys Ile Ser Ala Lys Val Ile Ser Gly Val Leu Lys Gly 
        115                 120                 125             


Glu Pro Lys Pro Arg Lys Leu Asp Phe Arg Ser Asp Leu Ser Lys Glu 
    130                 135                 140                 


Thr Arg Lys Asn Ser Ser Cys Leu Arg Lys Lys Arg Arg Asn Leu Thr 
145                 150                 155                 160 


Met Leu Pro Arg Leu Val Ser Asn Ser Leu Ser Gln Gly Ile Leu Pro 
                165                 170                 175     


Pro Trp Pro Pro Lys Ala Leu Gly Leu Ser Ala 
            180                 185         

<210>  2866
<211>  5408
<212>  DNA
<213>  Homo sapiens

<400>  2866
gccgcagtgc gactgcgcac agtctaatcc gcggggagag agaattgcgc atgcgcgcct     60

gtctcccggg acgctagagc aggcggttcc tgggctgctc cggtaggttt ggcgtgcgcg    120

ggtttctgca gatctagggc gagcttgcac gttacatcac cgatgcatct cttcttgctt    180

gcttaatttg ccaccactta ggcctttctt gcagaattcg ccatatactc cttaagggcc    240

gcggaatcgg agcgaccttg gtgactggca aactctcggc agatgtgcgt gcactggttt    300

gatgcagacg tggttgtagg cgatttaatt tttcccagct ttgcagcgac tgttggcttc    360

ccagaacgga tctccccagc ctcgactgga agctgaggga caaaaattca taaaagcaat    420

tactctttcc cggcgaggct tctagaagag caagaagagc gatatgatta cacctgcagc    480

cctataaaga ttgatctgtc cgtctttccc ttacagtcgt ggcctgttaa acgttcctgt    540

gttgttcagt gccagaatga gtgaccgcta tttagaacaa aggattagta tcaaattttg    600

cgtgaaattg aacaagtctg caagtgagac ccaccatctt ttaaaagaag cttatgggga    660

tgaagtcatg tcaagggcca gagtttttga ctggcacaaa aggtttaaag aaggacggga    720

agatgttcga gatgatgccc gaagtgggcg tccagtcacc caccgaacag atgacaatat    780

ccagaaggtc aaggacttgg tttgttcaaa caggcagtta accgtgagga tgatggctga    840

agagttaaat ttagacaaag aaactgttag gctcattttg aaagaaaact tgaacatgag    900

gaagatttct gcaaaagtta tttcgggtgt tttgaaggag acggaacctc actatgttgc    960

ccaggctggt ctcgaactcc ttgtctcaag ggatcctccc accttggcct cccaaagctc   1020

tgggattatc agcatgagcc accatgccaa gccaaaacca ggagttcaat ggtgtaaatt   1080

ccagtctgag tccacaggcc gaagagcgag gagtgctgat gtacaagggc aggagaagat   1140

ggatgtcaca gctcaagaag cgagaacaaa tttgcccttc tatctttttg ttctattcag   1200

gtcctcaatg aattggatga tgtccatgca cattagggag ggctgcctct tcattactcg   1260

gtctaccaat tcaaatgcta atctcttccg gaaacatccc cacagacaca cccagaaata   1320

atgttttccc atctatctca gtaccccatg atccagtcaa gtgaacatat aaaattggct   1380

gtcacatctc cattttgttt atttatttac ttatttattt tagactagtt aagttcagta   1440

gtgagaaaga gggaaggaat agaacgagga gttcaatctg tgactgacag tgaacaattg   1500

attgagataa ctcactacct ttggaccagc catctccatt ttataaataa gaaaactgaa   1560

gctcagaaag gttgtctaaa ctgccaaagc catagaactt taagtgcgga aataggtttt   1620

gtgttcaatc tgcttctcta taaaatccca tacaggacat ccaggcatct aaaaggtagc   1680

tcagtatctc tgccttctct ccattgttag ccttgatgga caatttttgc tggagcaaat   1740

attctgaaaa agattcctcc tgtttcctat gggagtagac agcaagcagg tgaagccggg   1800

ctctcttgag cctgggaccc cccggtagga gcatttggct ggaaagatgt ggaagtcaat   1860

aagcatttcc tccaccaccc agaagcatct ccaagctcag gcaggaggtg ggcagtgaag   1920

gggaatacca agcatcctgc acatcaggta gaaggaggaa gcccaggcca tggcaggact   1980

tacctgttga gtcctgctgg gtttgggcaa tgtctcagca gagactggca tactctcagg   2040

cttttcactt ccttccttag actgggggcg cctcttgccc tgtgcatctt gcacaaagcc   2100

tggtcctgag taggtgccct gcaaaggtgc aggggatcaa tgggggtgac tgagtctaac   2160

tgaagaaaaa gaaggcattt caagtctcta taggttgggg actttaatga gtgtaaatag   2220

ctacccttta ttgagcattg tttatgtgtg gacacttttt atgcatgtat attggaatat   2280

ttttagctgt aagtaatgat aactaacagt gacttaaata agtagttatt ttctggcata   2340

ataagaattc caaaggtgct cctttggtct ttccatcttg gttacaagat ggctgtgaca   2400

ccctgccctc acctccaagt tcaaggcagg caggggttgg gaggtgcgga cagttcagac   2460

tcagcagtcc tgtttcatca ggaaagcaaa agctctccca gtaactccca gcagagttct   2520

actaaatctc attggcccaa gggagctgca gtggtaggta acaaggagca aatggctttt   2580

gggtagccag tcaacagggt ctgccatgtg catagaaagc acagtatgta tttggcatgg   2640

agtcggtact caataagcat tagctatttg gcgtgcctgt gtgtgtttgt gtgtctgcgt   2700

gtggttatat gtatattttc cattttccca aacagtcctt ggaagtagca tcctccttta   2760

ctaatgggac ctaacacaca gctggcaaaa ggcacagtta gagccacaca tcagactcat   2820

ttctttctga ctgaagtctg agggctcttt ccattgccat gctatgttcc accctcccct   2880

tcaactgccc ctctaaagtc ttgtcttgga gtcacatgag gtccaagtgg gcttgatgaa   2940

gaaagaatag ggaaggagat cagatcagta ctgttgtcca ggctggagcg cagttgattg   3000

tagctcactg cagcctccaa ctccatggct caagtgatcc tcctgcctca gccttccaag   3060

tagctaggac aacaggtgcg tgctaccatg catggctaat taattaaaag aatttttttt   3120

ggtagagaca gggtctcact atgttgccca ggctggtctt gaactcctgg gctccagtga   3180

tcctccccct tcagcctccc aaagtgctag aattacaggc attagccacc atgcctggcc   3240

tggagatcag ttctttttta cttttttttg agacaggctc tccctatgtc accgaggcta   3300

cagtgcagtg gttcaatcgc agctcactgt agcctctatc tcctgggctc aagtgatcct   3360

cccacctcag cctcctgagt agctgggact agaggcatgt atcaccatgc ccagctaatt   3420

tttgcatttt ttgtagagtc agggtttcac cctgttgccc actctggtct caaactcctg   3480

ggctcaacca atctgcccac ctaggcctcc caaaatgctg ggactatagg tgtgagccac   3540

tgcacctggc ctggagctca gttctgaaat aagttgacac ctgtccctgg ggctatccac   3600

agagtaacga tgaagtcatg agaggaggtt caataactgt gtgctagagt catacctcca   3660

cctgagtgca gccactttgg aatggtcagg ctagaaggtt cagcctttat tctgatgatg   3720

ccactactgc ccagaactcc tctgggactc tttgcaagtt gcaaaagacc tcaatctcat   3780

tactgtaata ttgcacctca tttctgaccc caaacccagc tgcagcttct catctcacga   3840

atttcaagtg acttttgact attgccaaaa atcaaaaatc attccctgaa aacagaatct   3900

attgtaattt agatgcaaaa gaatgtgttg tctgctttgc agccaatttt caaataaaaa   3960

agaaatgttt aaagcagtgg aagcactgtt taaataaata tgccgggcca ggcgtggtgg   4020

ctcacgcctg taatcccagc actttaggag gccaaggcgg gtcgatcacg aagtcaggag   4080

atcgagacca acctggctaa cacagtgaaa ccccgtctct accaaaaata caaaaaatta   4140

gctgggagtg gtggcgggtg cctgtagtcc cagctatttg ggaggctgag gcaggagaat   4200

ggcaagaacc tgggaggcgg agcttgcagt gagccaaggt cacaccactg cactccagcc   4260

tgggctacag agcgagactc tgtctcaaaa aataaataaa ataaaataaa ataaataaat   4320

aaataaatat gccctcccag gttgacatct tggaagagga taactctaag tttggttgta   4380

taatttctgc tgtgtttaag aaaaattact taacttgtga gacattatga aaaggatgct   4440

ggacttggta aagatacaaa tgggcttata atgttggtca ggtgagacat gttgcattgg   4500

tgaaattata aattgatatt gttttctcag agcaatttcg caatgagcat cacgaagctt   4560

taaagagttt aaaccacacc ggtcacagtg gttcacgcct gtaatcccaa tactttggga   4620

ggccgaggtg ggcagatcac aagtcaggag ctagagacca gcctggtcaa catggtgaaa   4680

ccccttctct actaaaaata caaaaattag ctgggtgtgg tggtgcatgc ctgtaatccc   4740

agctactcgg gaggctgagg caggagcatc gcttgaacct gggaggtgga ggttgcagtg   4800

agctgagatc gcaccactgc actccagcct gggcggcaga gcaagactcc ctctcaaaaa   4860

aaaaaaaaaa aaaaaaaaaa aagaatttaa gccagttgac ctaggaatct tctaggacga   4920

tttcttagga atctttctta ggaaaacagt cagagatgca gacaaagatt tatgtaacag   4980

ccattcattg cagacttatt tgtaaaagta gtaaaaagaa ggaaataacc caaatgtccc   5040

acaatggaga aattgttaag aaaattacag catactcatt aagtgaaata atgcagctat   5100

ttaagatgat gtttttaaag aactgtcaat gatgtttgaa gatgttcaca ataagatagg   5160

tgataaaaca gactataaaa ccacatgcat tatatagtcc catttttact ttctgtatgc   5220

taaaacaaac ccctcaagat agatccaaaa cattaccagt ggtttgatct gggtgatgaa   5280

attataagtg attttaaact tgcttcatta tgcttttata tatataattt ttcttattat   5340

aacaataaat attacttttg tagttagaaa atatgtataa tgaacattaa aattacttgt   5400

taagaaag                                                            5408


<210>  2867
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  2867


Met Ser Asp Arg Tyr Leu Glu Gln Arg Ile Ser Ile Lys Phe Cys Val 
1               5                   10                  15      


Lys Leu Asn Lys Ser Ala Ser Glu Thr His His Leu Leu Lys Glu Ala 
            20                  25                  30          


Tyr Gly Asp Glu Val Met Ser Arg Ala Arg Val Phe Asp Trp His Lys 
        35                  40                  45              


Arg Phe Lys Glu Gly Arg Glu Asp Val Arg Asp Asp Ala Arg Ser Gly 
    50                  55                  60                  


Arg Pro Val Thr His Arg Thr Asp Asp Asn Ile Gln Lys Val Lys Asp 
65                  70                  75                  80  


Leu Val Cys Ser Asn Arg Gln Leu Thr Val Arg Met Met Ala Glu Glu 
                85                  90                  95      


Leu Asn Leu Asp Lys Glu Thr Val Arg Leu Ile Leu Lys Glu Asn Leu 
            100                 105                 110         


Asn Met Arg Lys Ile Ser Ala Lys Val Ile Ser Gly Val Leu Lys Glu 
        115                 120                 125             


Thr Glu Pro His Tyr Val Ala Gln Ala Gly Leu Glu Leu Leu Val Ser 
    130                 135                 140                 


Arg Asp Pro Pro Thr Leu Ala Ser Gln Ser Ser Gly Ile Ile Ser Met 
145                 150                 155                 160 


Ser His His Ala Lys Pro Lys Pro Gly Val Gln Trp Cys Lys Phe Gln 
                165                 170                 175     


Ser Glu Ser Thr Gly Arg Arg Ala Arg Ser Ala Asp Val Gln Gly Gln 
            180                 185                 190         


Glu Lys Met Asp Val Thr Ala Gln Glu Ala Arg Thr Asn Leu Pro Phe 
        195                 200                 205             


Tyr Leu Phe Val Leu Phe Arg Ser Ser Met Asn Trp Met Met Ser Met 
    210                 215                 220                 


His Ile Arg Glu Gly Cys Leu Phe Ile Thr Arg Ser Thr Asn Ser Asn 
225                 230                 235                 240 


Ala Asn Leu Phe Arg Lys His Pro His Arg His Thr Gln Lys 
                245                 250                 

<210>  2868
<211>  4228
<212>  DNA
<213>  Homo sapiens

<400>  2868
agaattgcgc atgcgcgcct gtctcccggg acgctagagc aggcggttcc tgggctgctc     60

cgagacggaa cctcactatg ttgcccaggc tggtctcgaa ctccttgtct caagggatcc    120

tcccaccttg gcctcccaaa gctctgggat tatcagcatg agccaccatg ccaagccaaa    180

accaggagtt caatggtgta aattccagtc tgagtccaca ggccgaagag cgaggagtgc    240

tgatgtacaa gggcaggaga agatggatgt cacagctcaa gaagcgagaa caaatttgcc    300

cttctatctt tttgttctat tcagcccagg atccctggga caggaagcag cagcagttaa    360

acagtcacac atcagtgctc cagcaagtga actgaggtgc atccaactaa ggagcagatc    420

caggaccaga ggaaataaaa ttatctggga gcagggccag gaaggtgctg gtctgcacgg    480

tcgatgcatt ttcaacgagc agtgattctg ttcctcatct ttcattgctt tatgggactt    540

cagggaatga aagcataaca tcctgctttc ccataagttc tctggctgct acactggcac    600

caattaaaga catgtctatg caattaatca aaaccaattt ggaagcactc tggtgctgct    660

cctctgatgt gctgcctgct ccacatacag tagttcctca gctgcggtga tggagccagg    720

cacataggag cttttgatga actggctgta ctggccccaa gtgttaacta tgtcatctga    780

catgactaat gaggctccgg acttgatccg cgtgagcgga gcagccctgc tgtctggagg    840

aggctcagtt tccacagcca gcctgggaag aggctgcaac gtgcagggta cacactgcat    900

catgtcagct ggagtcctag aggcctctag cgttggagct gggagtcatc catggagagg    960

gtgatggaaa ctgtgggcca ggctctgtgt tgggcgccag tgtgaatgtg acccaattta   1020

aacttctagc tcagcctcct cattttagac ctgaaaatca agacccagca aaagtgtgag   1080

gcttgccaaa gacctgaact ttggagagag aaatgatgga gaaagcaggg tctctgccct   1140

agatgagagg taaatatgta tgagggtaac aactggggcc tggtgcaagt atacttcatc   1200

aagggttaac cataggcttc ctttcttcct tctgcaaacc tttatcaagg ggaagggttg   1260

cttgtgccct tgtcacctca gcaattccaa gagcatggaa tttggagtca acagatctgt   1320

gtttgagtcc cagccctact ttgagttgat gtaatcttgc aaatcacttc atttttctga   1380

gccttggttt cctcagctgt aacattggaa taggccatat actgcccagc cagcctacct   1440

ccatgagccc ttctgtgact caactgagtt aatgggtgtg aaagtgtaag taagagcctc   1500

tgcacgtgtt agttattatt ccagttttca tccccctaag gagcactggc tgaaatctct   1560

ggaatatgga tccacagata gctttaactc tcttcctctt cctgcctctt tcaaatggac   1620

ataaaaacca attggtcatc cgcctaaaat ctcaacagct ttcccagaga gcccatgcat   1680

agaaagagga agaactcaac cgttgtaaat taatgtcatt ccatacattg attgagcacc   1740

taccacatgc cagacattgt gtgagggatc ggagttggat aagacatgtt tcttggccac   1800

cttgagaagc tcaccattta gtaggagaaa cagagctggg cataaataac tataatgtac   1860

tgcagacaaa tgcaattgcc ataggaaaga tacaaatcaa gtgttttggg agccagagga   1920

tggagtgatt cattccccaa aaggagactg gaaaaaggtt catcaacgaa gtggtactga   1980

aggatgggca gggcttagct ctgtcaggaa gaacgaggca gggcactcca gacagagaga   2040

ccagcatagg caaatgtatg aaatctggaa aggaatggtg atctaaagga cagaataaaa   2100

tcaagtaagg tattgggagt gagcatgaat caaagaaaaa tcactgcacc ccaactctga   2160

aactcaggca taaatgttgc tgtttcactg ttctctttgc tggctgaggt caccttggcc   2220

tctgtccctc agtcagagaa aatcccacac tggcccttcc tccagcaaag ccaaacccaa   2280

gccccagcca gcagaagcaa aaacaaatga acagggatca acaataccat tagatgcaaa   2340

aattcttgag ctgggaaggc caggtcacag ccatacctcc ccagccaggg taacagcttg   2400

atcagatgtg gcaatgacac caaccctgga gcacgatggc aaggaactta acttaagcct   2460

cttggcatgg gtcacaggct acatttttct ccttcccccc tcatccaaaa gaagctagct   2520

tcttctttat gagtgctgct gtcagaatgg ctttggaaag cctagagctg cagctgaact   2580

caaggcatgg ccatgggcca ccccagggac ttgtattttc tcagtctttc tatctttcgt   2640

tgcgaatttt ttttattgtg caaataatac agtgttaaga acggaaactt caagaagaga   2700

aagaggaaag agagcatcca ctcacatgtc atctgtttcc atttctcctt gccctttcct   2760

gctgttgtcc atgagcataa ttttttggcc gcttttatta ctgatacaac tacgtattct   2820

gtttttattg cttagccttg tatcatacaa ggctacttat tgccagcccc tggtgtccac   2880

actggcttgg cattgttctc ccaagactga aaaaatatgc caggtgtcat gtaaagggac   2940

tttccgcaga taacatgatc gccattgaca actggcatca tgtggcagag gaaaagcttc   3000

gaccgctctg ccatcatgtt gacttgggtt ggaatctcag ctcctctact tcgaagctag   3060

atggccctgg gcagatcatt ccatctcttt gagccacagt tcctcatcta taagatgggg   3120

atggcattag taccatctta tgatactaat gggatcacag tgagaattaa gtgagatacc   3180

aaaaggggaa tgctcaataa agagcagctc tccttcccaa cccttgaggg gctgacctag   3240

acaccactct gctttttcct ctcttgccca catttggcca cctcccctcc cctggaccca   3300

gcaggccccc tgggtgagcc cacctaaatt atgacaggca taccagtctg catatttatt   3360

attcactggg tgaatttgct atcttttact taagtatttt cctctgatga aacttttgtt   3420

tttgtccagt ttttcactat ttccaataat gatgcaaaaa aaaataccag tgtgtgccgc   3480

tcaccctatg ctttaaaaat tgtattttct cagaaacaat ccccaggagt aggatcactg   3540

agatagagga tagaaacatt ttcaaggttt ctgatgtgta tttccaaatt gcttttcaga   3600

tttgtacctg ttatgctgcc accaatttga gggagggaac cacttaggct acattggagg   3660

ccgctgggcc ctggtcacaa acttctgtct ctgctttatt tctaccattg tcttctctta   3720

acatggctcc tgaacttctc actctatggg acaattcatt gtttgtcccc aaaatgatgc   3780

tcccatactt ttgtgccttt gtacttccta ttagtcttca ccacccttgc ccaagaatat   3840

tcttccttta agataccctc tcaccttaga gctcaacctt tgtggaactg ggaacttcta   3900

tactctcttc aagacccagt tcaaacaccc ctctctccgt gaaccagttc caatcccccc   3960

aagcagagtt cgtcactttt gttataagtg gtacctggag gaacccttgg catccaagtg   4020

ttcaccaaga gtcagccatc ccctaacctc agctacaggc cccagttttc gtgattctct   4080

cttctctttt cctctctcac tctttgcacc aggcaatctc accaggtttt cccaactcat   4140

gtcctaaata ttcttagatc cacttatctt tgcctcatgg tcattgccag agctatcacc   4200

tctccaggat tcctgcaatg gtccccac                                      4228


<210>  2869
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  2869


Met Ser His His Ala Lys Pro Lys Pro Gly Val Gln Trp Cys Lys Phe 
1               5                   10                  15      


Gln Ser Glu Ser Thr Gly Arg Arg Ala Arg Ser Ala Asp Val Gln Gly 
            20                  25                  30          


Gln Glu Lys Met Asp Val Thr Ala Gln Glu Ala Arg Thr Asn Leu Pro 
        35                  40                  45              


Phe Tyr Leu Phe Val Leu Phe Ser Pro Gly Ser Leu Gly Gln Glu Ala 
    50                  55                  60                  


Ala Ala Val Lys Gln Ser His Ile Ser Ala Pro Ala Ser Glu Leu Arg 
65                  70                  75                  80  


Cys Ile Gln Leu Arg Ser Arg Ser Arg Thr Arg Gly Asn Lys Ile Ile 
                85                  90                  95      


Trp Glu Gln Gly Gln Glu Gly Ala Gly Leu His Gly Arg Cys Ile Phe 
            100                 105                 110         


Asn Glu Gln 
        115 

<210>  2870
<211>  2899
<212>  DNA
<213>  Homo sapiens

<400>  2870
acttaggcct ttcttgcaga attcgccata tactccttaa gggccgcgga atcggagcga     60

ccttggtgac tggcaaactc tcggcagatg tgcgtgcact ggtttgatgc agacgtggtt    120

gtaggcgatt taatttttcc cagctttgca gcgactgttg gcttcccaga acggatctcc    180

ccagcctcga ctggaagctg agggacaaaa attcataaaa gcaattactc tttcccggcg    240

aggcttctag aagagcaaga agagcgatat gattacacct gcagccctat aaagattgat    300

ctgtccgtct ttcccttaca gtcgtggcct gttaaacgtt cctgtgttgt tcagtgccag    360

aatgagtgac cgctatttag aacaaaggat tagtatcaaa ttttgcgtga aattgaacaa    420

gtctgcaagt gagacccacc atcttttaaa agaagcttat ggggatgaag tcatgtcaag    480

ggccagagtt tttgactggc acaaaaggtt taaagaagga cgggaagatg ttcgagatga    540

tgcccgaagt gggcgtccag tcacccaccg aacagatgac aatatccaga aggtcaagga    600

cttggtttgt tcaaacaggc agttaaccgt gaggatgatg gctgaagagt taaatttaga    660

caaagaaact gttaggctca ttttgaaaga aaacttgaac atgaggaaga tttctgcaaa    720

agttatttcg ggtgttttga agggtgagcc taaaccacga aaacttgact ttcggtccga    780

tctttcaaag gaaactagga aaaatagctc atgtttgagg aaaaaggtaa caggttctga    840

aacatggagt tatctccagg gtgaagctgg tggggaaatg cccctgccgg tatcccatcc    900

cagagtccac tactctgcca gtcagcttct gcaggcgtca tcttcaacaa gccttccccc    960

cagggtagct gagaattggt tcaccccatg gtgagaggaa tgtgagttag ctgaaccaga   1020

actaggatgc tgcctcactg ttaggcacct tctttggctg ctcacgtatt tttcagtctt   1080

caccactcct ccctatgtgc catggccctc ctcattactc tttgctggac tcttggacca   1140

ttttccttgc tgttctccat aactttgaaa aacttttggc tgttcccttc tggtatttgc   1200

ttgttcttga tttcttttgc tcaacaagtt tggatttctt ctctgcccag accttagctt   1260

gttgtggctg tcctgttcct ttgttctcaa ccttctgcct cagaggatca tgccagtgag   1320

aagagaggaa caggatctcc tggaatctgt atctctgtgc ccagggaagc atgcttttct   1380

gggaggaccc caaaagaagg cttacagttt cagcctgctt tgcagtcagg gcctgaggta   1440

tggtacagaa ggtagtagca tgctggtatt actgaacagt gctgggccta ggggctgatc   1500

tggcccagat gactcagtag gcacccttag gaatcagggg ttggccacca atactgatct   1560

tctcacaggc ctacacctca cagaagagct gggtttgttt cattctagtc ctatgctttg   1620

gacctccact catttgggta tcacccctgt tggaagagga ggatctggtg ctagaaaata   1680

taaacccggg gacccaggca aggctgtgtt gtgtggggag gaagaccagg tggctctcta   1740

gtccctgaat taagggagcc tgctgcctat gtgcggattc ccacacagca gcctgttttt   1800

agtaactaat gcctatagtt ttgagaactt gctgttttta ggacactgct gggcattgac   1860

aatgtggagg ttatgaacaa gatctccaag ggctgatggg cttcatggat gagatggttc   1920

ttgaactgga tccatgagga tgggtgagac agggctgtga aattagggaa agcttccggg   1980

gcaggtggaa cagcatgagg cttccaacct gcatcagtag aaaatgacac tggccaggtg   2040

tggtgaatca cgcctgtaat cccagcactt tgggagactg aggtgggtgg atcacaaggt   2100

caagagatcg agaccatcct ggccaacatg gtgaaacccc gtctctacta aaaatacaaa   2160

aattagctgg gcgtggtggt gcacacctgt agtcccaact actcaggagg ctgaggcagg   2220

agaatctgtt gaacccggaa ggcagaggtt gcagtgagtg gagattgcgc cactgtactc   2280

caacctggcg acagagctag actctgtccc aaaaaaaaaa aaaaggaatt agaaaatgat   2340

gacactattg gctaaaataa caaagtttaa agaggaagat aatggtgttg cagcagatga   2400

acaatttggg ataatttgct ttctctccta agcctccaac tctatgccac ttgttgttaa   2460

attgcttccc ctgagtctgt gaataggttt gtaacaacca atttgatatc tgattttcca   2520

tttggacccc gacaagcagt ttctgcaagt tcaaactctg tctcttctct tcctgcctct   2580

gccaggattt atggaatgga acttttccca agtgggttcc aagtaatacc acatagactg   2640

gaaacattca gggggcaggg gtttggtaat agcatttcac agaattggcc agtctttgtt   2700

ttactcaagg atttttagat ataacagctc ctcttaaaca atattgcttg atagtagagg   2760

cacaacactc attcatcaca gttactttta gtgctgttct ttcactttct ctactcacct   2820

ccaaaaatta caagttcctc attaacacct gtttttgttt tgttttgttt tttgagatgg   2880

agtcttgctc tgctgccca                                                2899


<210>  2871
<211>  210
<212>  PRT
<213>  Homo sapiens

<400>  2871


Met Ser Asp Arg Tyr Leu Glu Gln Arg Ile Ser Ile Lys Phe Cys Val 
1               5                   10                  15      


Lys Leu Asn Lys Ser Ala Ser Glu Thr His His Leu Leu Lys Glu Ala 
            20                  25                  30          


Tyr Gly Asp Glu Val Met Ser Arg Ala Arg Val Phe Asp Trp His Lys 
        35                  40                  45              


Arg Phe Lys Glu Gly Arg Glu Asp Val Arg Asp Asp Ala Arg Ser Gly 
    50                  55                  60                  


Arg Pro Val Thr His Arg Thr Asp Asp Asn Ile Gln Lys Val Lys Asp 
65                  70                  75                  80  


Leu Val Cys Ser Asn Arg Gln Leu Thr Val Arg Met Met Ala Glu Glu 
                85                  90                  95      


Leu Asn Leu Asp Lys Glu Thr Val Arg Leu Ile Leu Lys Glu Asn Leu 
            100                 105                 110         


Asn Met Arg Lys Ile Ser Ala Lys Val Ile Ser Gly Val Leu Lys Gly 
        115                 120                 125             


Glu Pro Lys Pro Arg Lys Leu Asp Phe Arg Ser Asp Leu Ser Lys Glu 
    130                 135                 140                 


Thr Arg Lys Asn Ser Ser Cys Leu Arg Lys Lys Val Thr Gly Ser Glu 
145                 150                 155                 160 


Thr Trp Ser Tyr Leu Gln Gly Glu Ala Gly Gly Glu Met Pro Leu Pro 
                165                 170                 175     


Val Ser His Pro Arg Val His Tyr Ser Ala Ser Gln Leu Leu Gln Ala 
            180                 185                 190         


Ser Ser Ser Thr Ser Leu Pro Pro Arg Val Ala Glu Asn Trp Phe Thr 
        195                 200                 205             


Pro Trp 
    210 

<210>  2872
<211>  711
<212>  DNA
<213>  Homo sapiens

<400>  2872
gagaagagag gaacaggatc tcctggaatc tgtatctctg tgcccaggga agcatgcttt     60

tctgggagga ccccaaaaga aggcttacag tttcagcctg ctttgcagtc agggcctgag    120

cccaggatcc ctgggacagg aagcagcagc agttaaacag tcacacatca gtgctccagc    180

aagtgaactg aggtgcatcc aactaaggag cagatccagg accagaggaa ataaaattat    240

ctgggagcag ggccaggaag gtgctggtct gcacggtcga tgcattttca acgagcagtg    300

attctgttcc tcatctttca ttgctttatg ggacttcagg gaatgaaagc ataacatcct    360

gctttcccat aagttctctg gctgctacac tggcaccaat taaagacatg tctatgcaat    420

taatcaaaac caatttggaa gcactctggt gctgctcctc tgatgtgctg cctgctccac    480

atacagtagt tcctcagctg cggtgatgga gccaggcaca taggagcttt tgatgaactg    540

gctgtactgg ccccaagtgt taactatgtc atctgacatg actaatgagg ctccggactt    600

gatccgcgtg agcggagcag ccctgctgtc tggaggaggc tcagtttcca cagccagcct    660

gggaagaggc tgcaacgtgc agggtacaca ctgcatcatg tcagctggag t             711


<210>  2873
<211>  58
<212>  PRT
<213>  Homo sapiens

<400>  2873


Met Asn Trp Leu Tyr Trp Pro Gln Val Leu Thr Met Ser Ser Asp Met 
1               5                   10                  15      


Thr Asn Glu Ala Pro Asp Leu Ile Arg Val Ser Gly Ala Ala Leu Leu 
            20                  25                  30          


Ser Gly Gly Gly Ser Val Ser Thr Ala Ser Leu Gly Arg Gly Cys Asn 
        35                  40                  45              


Val Gln Gly Thr His Cys Ile Met Ser Ala 
    50                  55              

<210>  2874
<211>  2902
<212>  DNA
<213>  Homo sapiens

<400>  2874
aaaaaaaaaa agtgatgagt tgtgaggcag gtcgcggccc tactgcctca ggagacgatg     60

cgcagctcat ttgcttaaat ttgcagctga cggctgccac ctctctagag gcacctggcg    120

gggagcctct caacataaga cagtgaccag tctggtgact cacagccggc acagccatga    180

actacccgct aacgctggaa atggacctcg agaacctgga ggacctgttc tgggaactgg    240

acagattgga caactataac gacacctccc tggtggaaaa tcatctctgc cctgccacag    300

aggggcccct catggcctcc ttcaaggccg tgttcgtgcc cgtggcctac agcctcatct    360

tcctcctggg cgtgatcggc aacgtcctgg tgctggtgat cctggagcgg caccggcaga    420

cacgcagttc cacggagacc ttcctgttcc acctggccgt ggccgacctc ctgctggtct    480

tcatcttgcc ctttgccgtg gccgagggct ctgtgggctg ggtcctgggg accttcctct    540

gcaaaactgt gattgccctg cacaaagtca acttctactg cagcagcctg ctcctggcct    600

gcatcgccgt ggaccgctac ctggccattg tccacgccgt ccatgcctac cgccaccgcc    660

gcctcctctc catccacatc acctgtggga ccatctggct ggtgggcttc ctccttgcct    720

tgccagagat tctcttcgcc aaagtcagcc aaggccatca caacaactcc ctgccacgtt    780

gcaccttctc ccaagagaac caagcagaaa cgcatgcctg gttcacctcc cgattcctct    840

accatgtggc gggattcctg ctgcccatgc tggtgatggg ctggtgctac gtgggggtag    900

tgcacaggtt gcgccaggcc cagcggcgcc ctcagcggca gaaggcagtc agggtggcca    960

tcctggtgac aagcatcttc ttcctctgct ggtcacccta ccacatcgtc atcttcctgg   1020

acaccctggc gaggctgaag gccgtggaca atacctgcaa gctgaatggc tctctccccg   1080

tggccatcac catgtgtgag ttcctgggcc tggcccactg ctgcctcaac cccatgctct   1140

acactttcgc cggcgtgaag ttccgcagtg acctgtcgcg gctcctgacg aagctgggct   1200

gtaccggccc tgcctccctg tgccagctct tccctagctg gcgcaggagc agtctctctg   1260

agtcagagaa tgccacctct ctcaccacgt tctaggtccc agtgtcccct tttattgctg   1320

cttttccttg gggcaggcag tgatgctgga tgctccttcc aacaggagct gggatcctaa   1380

gggctcaccg tggctaagag tgtcctagga gtatcctcat ttggggtagc tagaggaacc   1440

aacccccatt tctagaacat ccctgccagc tcttctgccg gccctggggc taggctggag   1500

cccagggagc ggaaagcagc tcaaaggcac agtgaaggct gtccttaccc atctgcaccc   1560

ccctgggctg agagaacctc acgcacctcc catcctaatc atccaatgct caagaaacaa   1620

cttctacttc tgcccttgcc aacggagagc gcctgcccct cccagaacac actccatcag   1680

cttaggggct gctgacctcc acagcttccc ctctctcctc ctgcccacct gtcaaacaaa   1740

gccagaagct gagcaccagg ggatgagtgg aggttaaggc tgaggaaagg ccagctggca   1800

gcagagtgtg gccttcggac aactcagtcc ctaaaaacac agacattctg ccaggccccc   1860

aagcctgcag tcatcttgac caagcaggaa gctcagactg gttgagttca ggtagctgcc   1920

cctggctctg accgaaacag cgctgggtcc accccatgtc accggatcct gggtggtctg   1980

caggcagggc tgactctagg tgcccttgga ggccagccag tgacctgagg aagcgtgaag   2040

gccgagaagc aagaaagaaa cccgacagag ggaagaaaag agctttcttc ccgaacccca   2100

aggagggaga tggatcaatc aaacccggcg gtcccctccg ccaggcgaga tggggtgggg   2160

tggagaactc ctagggtggc tgggtccagg ggatgggagg ttgtgggcat tgatggggaa   2220

ggaggctggc ttgtcccctc ctcactccct tcccataagc tatagacccg aggaaactca   2280

gagtcggaac ggagaaaggt ggactggaag gggcccgtgg gagtcatctc aaccatcccc   2340

tccgtggcat caccttaggc agggaagtgt aagaaacaca ctgaggcagg gaagtcccca   2400

ggccccagga agccgtgccc tgcccccgtg aggatgtcac tcagatggaa ccgcaggaag   2460

ctgctccgtg cttgtttgct cacctggggt gtgggaggcc cgtccggcag ttctgggtgc   2520

tccctaccac ctccccagcc tttgatcagg tggggagtca gggacccctg cccttgtccc   2580

actcaagcca agcagccaag ctccttggga ggccccactg gggaaataac agctgtggct   2640

cacgtgagag tgtcttcacg gcaggacaac gaggaagccc taagacgtcc cttttttctc   2700

tgagtatctc ctcgcaagct gggtaatcga tgggggagtc tgaagcagat gcaaagaggc   2760

aagaggctgg attttgaatt ttctttttaa taaaaaggca cctataaaac aggtcaatac   2820

agtacaggca gcacagagac ccccggaaca agcctaaaaa ttgtttcaaa ataaaaacca   2880

agaagatgtc ttcacatatt gt                                            2902


<210>  2875
<211>  372
<212>  PRT
<213>  Homo sapiens

<400>  2875


Met Asn Tyr Pro Leu Thr Leu Glu Met Asp Leu Glu Asn Leu Glu Asp 
1               5                   10                  15      


Leu Phe Trp Glu Leu Asp Arg Leu Asp Asn Tyr Asn Asp Thr Ser Leu 
            20                  25                  30          


Val Glu Asn His Leu Cys Pro Ala Thr Glu Gly Pro Leu Met Ala Ser 
        35                  40                  45              


Phe Lys Ala Val Phe Val Pro Val Ala Tyr Ser Leu Ile Phe Leu Leu 
    50                  55                  60                  


Gly Val Ile Gly Asn Val Leu Val Leu Val Ile Leu Glu Arg His Arg 
65                  70                  75                  80  


Gln Thr Arg Ser Ser Thr Glu Thr Phe Leu Phe His Leu Ala Val Ala 
                85                  90                  95      


Asp Leu Leu Leu Val Phe Ile Leu Pro Phe Ala Val Ala Glu Gly Ser 
            100                 105                 110         


Val Gly Trp Val Leu Gly Thr Phe Leu Cys Lys Thr Val Ile Ala Leu 
        115                 120                 125             


His Lys Val Asn Phe Tyr Cys Ser Ser Leu Leu Leu Ala Cys Ile Ala 
    130                 135                 140                 


Val Asp Arg Tyr Leu Ala Ile Val His Ala Val His Ala Tyr Arg His 
145                 150                 155                 160 


Arg Arg Leu Leu Ser Ile His Ile Thr Cys Gly Thr Ile Trp Leu Val 
                165                 170                 175     


Gly Phe Leu Leu Ala Leu Pro Glu Ile Leu Phe Ala Lys Val Ser Gln 
            180                 185                 190         


Gly His His Asn Asn Ser Leu Pro Arg Cys Thr Phe Ser Gln Glu Asn 
        195                 200                 205             


Gln Ala Glu Thr His Ala Trp Phe Thr Ser Arg Phe Leu Tyr His Val 
    210                 215                 220                 


Ala Gly Phe Leu Leu Pro Met Leu Val Met Gly Trp Cys Tyr Val Gly 
225                 230                 235                 240 


Val Val His Arg Leu Arg Gln Ala Gln Arg Arg Pro Gln Arg Gln Lys 
                245                 250                 255     


Ala Val Arg Val Ala Ile Leu Val Thr Ser Ile Phe Phe Leu Cys Trp 
            260                 265                 270         


Ser Pro Tyr His Ile Val Ile Phe Leu Asp Thr Leu Ala Arg Leu Lys 
        275                 280                 285             


Ala Val Asp Asn Thr Cys Lys Leu Asn Gly Ser Leu Pro Val Ala Ile 
    290                 295                 300                 


Thr Met Cys Glu Phe Leu Gly Leu Ala His Cys Cys Leu Asn Pro Met 
305                 310                 315                 320 


Leu Tyr Thr Phe Ala Gly Val Lys Phe Arg Ser Asp Leu Ser Arg Leu 
                325                 330                 335     


Leu Thr Lys Leu Gly Cys Thr Gly Pro Ala Ser Leu Cys Gln Leu Phe 
            340                 345                 350         


Pro Ser Trp Arg Arg Ser Ser Leu Ser Glu Ser Glu Asn Ala Thr Ser 
        355                 360                 365             


Leu Thr Thr Phe 
    370         

<210>  2876
<211>  4890
<212>  DNA
<213>  Homo sapiens

<400>  2876
aaaaaaaaaa agtgatgagt tgtgaggcag gtcgcggccc tactgcctca ggagacgatg     60

cgcagctcat ttgcttaaat ttgcagctga cggctgccac ctctctagag gcacctggcg    120

gggagcctct caacataaga cagtgaccag tctggtgact cacagccggc acagccatga    180

actacccgct aacgctggaa atggacctcg agaacctgga ggacctgttc tgggaactgg    240

acagattgga caactataac gacacctccc tggtggaaaa tcatctctgc cctgccacag    300

aggggcccct catggcctcc ttcaaggccg tgttcgtgcc cgtggcctac agcctcatct    360

tcctcctggg cgtgatcggc aacgtcctgg tgctggtgat cctggagcgg caccggcaga    420

cacgcagttc cacggagacc ttcctgttcc acctggccgt ggccgacctc ctgctggtct    480

tcatcttgcc ctttgccgtg gccgagggct ctgtgggctg ggtcctgggg accttcctct    540

gcaaaactgt gattgccctg cacaaagtca acttctactg cagcagcctg ctcctggcct    600

gcatcgccgt ggaccgctac ctggccattg tccacgccgt ccatgcctac cgccaccgcc    660

gcctcctctc catccacatc acctgtggga ccatctggct ggtgggcttc ctccttgcct    720

tgccagagat tctcttcgcc aaagtcagcc aaggccatca caacaactcc ctgccacgtt    780

gcaccttctc ccaagagaac caagcagaaa cgcatgcctg gttcacctcc cgattcctct    840

accatgtggc gggattcctg ctgcccatgc tggtgatggg ctggtgctac gtgggggtag    900

tgcacaggtt gcgccaggcc cagcggcgcc ctcagcggca gaaggcagtc agggtggcca    960

tcctggtgac aagcatcttc ttcctctgct ggtcacccta ccacatcgtc atcttcctgg   1020

acaccctggc gaggctgaag gccgtggaca atacctgcaa gctgaatggc tctctccccg   1080

tggccatcac catgtgtgag ttcctgggcc tggcccactg ctgcctcaac cccatgctct   1140

acactttcgc cggcgtgaag ttccgcagtg acctgtcgcg gctcctgacg aagctgggct   1200

gtaccggccc tgcctccctg tgccagctct tccctagctg gcgcaggagc agtctctctg   1260

agtcagagaa tgccacctct ctcaccacgt tctaggtccc agtgtcccct tttattgctg   1320

cttttccttg gggcaggcag tgatgctgga tgctccttcc aacaggagct gggatcctaa   1380

gggctcaccg tggctaagag tgtcctagga gtatcctcat ttggggtagc tagaggaacc   1440

aacccccatt tctagaacat ccctgccagc tcttctgccg gccctggggc taggctggag   1500

cccagggagc ggaaagcagc tcaaaggcac agtgaaggct gtccttaccc atctgcaccc   1560

ccctgggctg agagaacctc acgcacctcc catcctaatc atccaatgct caagaaacaa   1620

cttctacttc tgcccttgcc aacggagagc gcctgcccct cccagaacac actccatcag   1680

cttaggggct gctgacctcc acagcttccc ctctctcctc ctgcccacct gtcaaacaaa   1740

gccagaagct gagcaccagg ggatgagtgg aggttaaggc tgaggaaagg ccagctggca   1800

gcagagtgtg gccttcggac aactcagtcc ctaaaaacac agacattctg ccaggccccc   1860

aagcctgcag tcatcttgac caagcaggaa gctcagactg gttgagttca ggtagctgcc   1920

cctggctctg accgaaacag cgctgggtcc accccatgtc accggatcct gggtggtctg   1980

caggcagggc tgactctagg tgcccttgga ggccagccag tgacctgagg aagcgtgaag   2040

gccgagaagc aagaaagaaa cccgacagag ggaagaaaag agctttcttc ccgaacccca   2100

aggagggaga tggatcaatc aaacccggcg gtcccctccg ccaggcgaga tggggtgggg   2160

tggagaactc ctagggtggc tgggtccagg ggatgggagg ttgtgggcat tgatggggaa   2220

ggaggctggc ttgtcccctc ctcactccct tcccataagc tatagacccg aggaaactca   2280

gagtcggaac ggagaaaggt ggactggaag gggcccgtgg gagtcatctc aaccatcccc   2340

tccgtggcat caccttaggc agggaagtgt aagaaacaca ctgaggcagg gaagtcccca   2400

ggccccagga agccgtgccc tgcccccgtg aggatgtcac tcagatggaa ccgcaggaag   2460

ctgctccgtg cttgtttgct cacctggggt gtgggaggcc cgtccggcag ttctgggtgc   2520

tccctaccac ctccccagcc tttgatcagg tggggagtca gggacccctg cccttgtccc   2580

actcaagcca agcagccaag ctccttggga ggccccactg gggaaataac agctgtggct   2640

cacgtgagag tgtcttcacg gcaggacaac gaggaagccc taagacgtcc cttttttctc   2700

tgagtatctc ctcgcaagct gggtaatcga tgggggagtc tgaagcagat gcaaagaggc   2760

aagaggctgg attttgaatt ttctttttaa taaaaaggca cctataaaac aggtcaatac   2820

agtacaggca gcacagagac ccccggaaca agcctaaaaa ttgtttcaaa ataaaaacca   2880

agaagatgtc ttcacatatt gtatttatat atttatattt atatatatat ttatataatg   2940

gtacaaaatg gctgggggtg tggccatgga tggagggaag agtaggctgg cctgtggcgt   3000

gggtgggagg agaggggacg gagagggcac tcggcccgct gcaatctgac ccctctctcc   3060

tcagggcagg aaacacagag tcagacagtt tgggggggtc ttgggccagg ggtggagggc   3120

tcaagggcac agggcccagg ctgaggcagg gcgggcaaag cgcctggcag gatgaagggc   3180

aagtggcccc ccaaacacag aggccctggc catggaccct gggaggtgac cggggtgagt   3240

caggggcctg ttgtcagccc cagaggaagc gctggacctg gccgatggtg ggccgagagg   3300

acagcaccag gctgggagaa gtggggcgag ttccctttgt attacagctg ccagtgcaag   3360

accaggccct ccaggccagg aaggctaggg acgggtcctg gtagaagaca ccctgtctag   3420

aatggccctt ggtcctggag gtggggcgca aaaggcctca gccagggaac tgccctgcca   3480

cctcccgagg caggaaagga agtgagaaaa ggagaagttt ttttactcct ggggccaaag   3540

tagggggaca aacacccagt cgtatatggc ttcagctctg accaaaggcg gatagggagc   3600

tctcctgggt aggagcaggg agccaagggg gaggcagtgg ctgtgcctgg gtgggcacag   3660

acagatctgg tacatggccc tgagccctgg gcagagggac aaccttgccg gtgagtgggc   3720

aggcagagag gaggcggcag gatgctgttt ccccgattcc atcctcaggg agtggagact   3780

ggaggggagg tgcactgact cagatgaact gttctccccc ttctttgata agaagtaggt   3840

ggcagcagcc tctggaaaag tcagggccct ggaggttacc tggcccaggg ctactacagc   3900

cacaggcccc agtggcacca tgccacccct tccatggctc cactcaaggg ggccacacag   3960

ccaccgcctc ttcctccttt ccttcatccc aaactgggac aaaagacttc aagttctggc   4020

taagatgtag cagcagcgga tgcccgggca tccaaagtgg aaagccaggg ccccgtgtca   4080

ccggtgtggg caaacacaca tgcacgtgca cacatgttct ccctgaatca ctcagcagca   4140

gacaggctgc cgccctgggg gtctcagccc tgctagggct caccaggtgg aagcctaggt   4200

ggtctgacct cagtttagga gtgggtcatt tacgtcatct taccatttgg ggacgagaca   4260

ggaatggtat cccttaggga cccagagaca ctgcaaacag tgggtggcca tgtagggctg   4320

catgtccctg ggtccagggg aatggaggga gcaataactt gaagaagggg ggaagggttt   4380

cttttatcct tttttttttg tgtgacttct atcaaaacac agaaatacag cacacgcaca   4440

aaccagcaca aaagcgcagc gctctattta cagctccggc tggcacctgc ccacctggcc   4500

agccgcctgc agggaggggt gggagagggg tcagccacat cagcagggaa aggatacgaa   4560

gcaggtaaag acagaaggaa aatgggcggg tgcggagaaa ccaagaggga ggtggagctc   4620

cagcaatgcg gacacgagga gacaggagca gaaggggctg ggggagacct gacctgtcct   4680

tcctctctcc ccccagattc ccatccagga ctccaaaagc atagctgaag ggggtgtggc   4740

gggtgcaggg atgcacggaa agaggtaaaa tagagaggct ccataggaat tgggaggagt   4800

gggggagggg cagtcctggt ggccgaaatg gaaccaaccc caatgcaaaa tcccccaccc   4860

cacactgcca cttcccccta agctgccagc                                    4890


<210>  2877
<211>  372
<212>  PRT
<213>  Homo sapiens

<400>  2877


Met Asn Tyr Pro Leu Thr Leu Glu Met Asp Leu Glu Asn Leu Glu Asp 
1               5                   10                  15      


Leu Phe Trp Glu Leu Asp Arg Leu Asp Asn Tyr Asn Asp Thr Ser Leu 
            20                  25                  30          


Val Glu Asn His Leu Cys Pro Ala Thr Glu Gly Pro Leu Met Ala Ser 
        35                  40                  45              


Phe Lys Ala Val Phe Val Pro Val Ala Tyr Ser Leu Ile Phe Leu Leu 
    50                  55                  60                  


Gly Val Ile Gly Asn Val Leu Val Leu Val Ile Leu Glu Arg His Arg 
65                  70                  75                  80  


Gln Thr Arg Ser Ser Thr Glu Thr Phe Leu Phe His Leu Ala Val Ala 
                85                  90                  95      


Asp Leu Leu Leu Val Phe Ile Leu Pro Phe Ala Val Ala Glu Gly Ser 
            100                 105                 110         


Val Gly Trp Val Leu Gly Thr Phe Leu Cys Lys Thr Val Ile Ala Leu 
        115                 120                 125             


His Lys Val Asn Phe Tyr Cys Ser Ser Leu Leu Leu Ala Cys Ile Ala 
    130                 135                 140                 


Val Asp Arg Tyr Leu Ala Ile Val His Ala Val His Ala Tyr Arg His 
145                 150                 155                 160 


Arg Arg Leu Leu Ser Ile His Ile Thr Cys Gly Thr Ile Trp Leu Val 
                165                 170                 175     


Gly Phe Leu Leu Ala Leu Pro Glu Ile Leu Phe Ala Lys Val Ser Gln 
            180                 185                 190         


Gly His His Asn Asn Ser Leu Pro Arg Cys Thr Phe Ser Gln Glu Asn 
        195                 200                 205             


Gln Ala Glu Thr His Ala Trp Phe Thr Ser Arg Phe Leu Tyr His Val 
    210                 215                 220                 


Ala Gly Phe Leu Leu Pro Met Leu Val Met Gly Trp Cys Tyr Val Gly 
225                 230                 235                 240 


Val Val His Arg Leu Arg Gln Ala Gln Arg Arg Pro Gln Arg Gln Lys 
                245                 250                 255     


Ala Val Arg Val Ala Ile Leu Val Thr Ser Ile Phe Phe Leu Cys Trp 
            260                 265                 270         


Ser Pro Tyr His Ile Val Ile Phe Leu Asp Thr Leu Ala Arg Leu Lys 
        275                 280                 285             


Ala Val Asp Asn Thr Cys Lys Leu Asn Gly Ser Leu Pro Val Ala Ile 
    290                 295                 300                 


Thr Met Cys Glu Phe Leu Gly Leu Ala His Cys Cys Leu Asn Pro Met 
305                 310                 315                 320 


Leu Tyr Thr Phe Ala Gly Val Lys Phe Arg Ser Asp Leu Ser Arg Leu 
                325                 330                 335     


Leu Thr Lys Leu Gly Cys Thr Gly Pro Ala Ser Leu Cys Gln Leu Phe 
            340                 345                 350         


Pro Ser Trp Arg Arg Ser Ser Leu Ser Glu Ser Glu Asn Ala Thr Ser 
        355                 360                 365             


Leu Thr Thr Phe 
    370         

<210>  2878
<211>  1360
<212>  DNA
<213>  Homo sapiens

<400>  2878
tcagtggctt aaggggtgca ggggtctgga gaaatgagac tgggctgtgg gtgagggtgt     60

aggtctgtac cccttacccc gtctttcttc aggaggccca cagcccctaa agaccatctg    120

agactctggc ttgccatttg tcacatctcc cttgccgcac ccacagcctt cagggacaag    180

tctgtgagac tcctctttca tctctaccca cgggttttgg ccatcagaag caggtccaca    240

tatgcggcca ctgtttctgc cgttctgcta gaggagtggg atcagctgca gcctgcgtcc    300

ctggggaaag caagagttcc tgacggagac tctgcagttt gtatgcccga acccatattc    360

actttgaccc tgacccatcc tcagcttggc cttggggctc tccctcatct ctgacccttc    420

caactacacc ccagttgggc ctcctctgct ggggttcctc tgggactttt gacctggttg    480

cggggggcgg gtggagaacc tccctttccc ctagatgaag cccagaaaca gcctgagctg    540

gttttggttc ctcttcttca cacctacatg atgaaatgag atggtccacg tggacgggct    600

gtgtcgcctg tgatgctctg gtcacactga agtcatgatg tgtggtaatt gtctatggag    660

aggggtcata gaaagccagg ctctggggct tggaccagct tcaccgtgcg ctatagcagc    720

ttcccctccc ggctggtgtg cagggtgggg ctggaggtat agtttatgac cagcctctgt    780

ggatgcccca gcccaggccc tggttctgtt ggaaggaggc tctcagatcg agggtcgcat    840

agacagggtc tgctctaggt ctgccaggat cggcctttcc agcaggatgg gtccctggca    900

tacccacccc aggacctgga atcttcttgt tcctggttct tagccatcta atttttgttc    960

tatttggacc tttcattgat gagaattagc agcccgtccc caccccccag cccctgcctt   1020

aaagaagtgg acattttaag cggctcgagt tggtcttcga gttcaagagg acaaatggaa   1080

tacagaatga cgaacctggc ttatggccag gagcccccag ttcctttttt tttttttttt   1140

ctggcaagtt tgtgtaacca aaaggcccca gttcttagct caacatgaga gtgtaaaacc   1200

cagcgttcaa ggaatgtgaa ccaatacctg gtatgggcaa ggacaaggag gagaatagga   1260

agcagaagga atagaaggac ccagactaac tccagaggaa aatggtgagc taagaccttt   1320

actgcatcac aaatcaataa atacttattg agaagctgct                         1360


<210>  2879
<211>  69
<212>  PRT
<213>  Homo sapiens

<400>  2879


Met Arg Ile Ser Ser Pro Ser Pro Pro Pro Ser Pro Cys Leu Lys Glu 
1               5                   10                  15      


Val Asp Ile Leu Ser Gly Ser Ser Trp Ser Ser Ser Ser Arg Gly Gln 
            20                  25                  30          


Met Glu Tyr Arg Met Thr Asn Leu Ala Tyr Gly Gln Glu Pro Pro Val 
        35                  40                  45              


Pro Phe Phe Phe Phe Phe Leu Ala Ser Leu Cys Asn Gln Lys Ala Pro 
    50                  55                  60                  


Val Leu Ser Ser Thr 
65                  

<210>  2880
<211>  2870
<212>  DNA
<213>  Homo sapiens

<400>  2880
ccactctaag gaatgcggtc cctttgacag gcgaaaaact gaagttggaa aagacaaagt     60

gatttgttca aaattgaaat ttgaaacttg acatttggtc agtgggccct atgtaggaaa    120

aaacctccaa gagagctagg gttcctctca gagaggaaag acaggtcctt aggtcctcac    180

cctcccgtct ccttgccctt gcagttctgg gaactggaca gattggacaa ctataacgac    240

acctccctgg tggaaaatca tctctgccct gccacagagg ggcccctcat ggcctccttc    300

aaggccgtgt tcgtgcccgt ggcctacagc ctcatcttcc tcctgggcgt gatcggcaac    360

gtcctggtgc tggtgatcct ggagcggcac cggcagacac gcagttccac ggagaccttc    420

ctgttccacc tggccgtggc cgacctcctg ctggtcttca tcttgccctt tgccgtggcc    480

gagggctctg tgggctgggt cctggggacc ttcctctgca aaactgtgat tgccctgcac    540

aaagtcaact tctactgcag cagcctgctc ctggcctgca tcgccgtgga ccgctacctg    600

gccattgtcc acgccgtcca tgcctaccgc caccgccgcc tcctctccat ccacatcacc    660

tgtgggacca tctggctggt gggcttcctc cttgccttgc cagagattct cttcgccaaa    720

gtcagccaag gccatcacaa caactccctg ccacgttgca ccttctccca agagaaccaa    780

gcagaaacgc atgcctggtt cacctcccga ttcctctacc atgtggcggg attcctgctg    840

cccatgctgg tgatgggctg gtgctacgtg ggggtagtgc acaggttgcg ccaggcccag    900

cggcgccctc agcggcagaa ggcagtcagg gtggccatcc tggtgacaag catcttcttc    960

ctctgctggt caccctacca catcgtcatc ttcctggaca ccctggcgag gctgaaggcc   1020

gtggacaata cctgcaagct gaatggctct ctccccgtgg ccatcaccat gtgtgagttc   1080

ctgggcctgg cccactgctg cctcaacccc atgctctaca ctttcgccgg cgtgaagttc   1140

cgcagtgacc tgtcgcggct cctgacgaag ctgggctgta ccggccctgc ctccctgtgc   1200

cagctcttcc ctagctggcg caggagcagt ctctctgagt cagagaatgc cacctctctc   1260

accacgttct aggtcccagt gtcccctttt attgctgctt ttccttgggg caggcagtga   1320

tgctggatgc tccttccaac aggagctggg atcctaaggg ctcaccgtgg ctaagagtgt   1380

cctaggagta tcctcatttg gggtagctag aggaaccaac ccccatttct agaacatccc   1440

tgccagctct tctgccggcc ctggggctag gctggagccc agggagcgga aagcagctca   1500

aaggcacagt gaaggctgtc cttacccatc tgcacccccc tgggctgaga gaacctcacg   1560

cacctcccat cctaatcatc caatgctcaa gaaacaactt ctacttctgc ccttgccaac   1620

ggagagcgcc tgcccctccc agaacacact ccatcagctt aggggctgct gacctccaca   1680

gcttcccctc tctcctcctg cccacctgtc aaacaaagcc agaagctgag caccagggga   1740

tgagtggagg ttaaggctga ggaaaggcca gctggcagca gagtgtggcc ttcggacaac   1800

tcagtcccta aaaacacaga cattctgcca ggcccccaag cctgcagtca tcttgaccaa   1860

gcaggaagct cagactggtt gagttcaggt agctgcccct ggctctgacc gaaacagcgc   1920

tgggtccacc ccatgtcacc ggatcctggg tggtctgcag gcagggctga ctctaggtgc   1980

ccttggaggc cagccagtga cctgaggaag cgtgaaggcc gagaagcaag aaagaaaccc   2040

gacagaggga agaaaagagc tttcttcccg aaccccaagg agggagatgg atcaatcaaa   2100

cccggcggtc ccctccgcca ggcgagatgg ggtggggtgg agaactccta gggtggctgg   2160

gtccagggga tgggaggttg tgggcattga tggggaagga ggctggcttg tcccctcctc   2220

actcccttcc cataagctat agacccgagg aaactcagag tcggaacgga gaaaggtgga   2280

ctggaagggg cccgtgggag tcatctcaac catcccctcc gtggcatcac cttaggcagg   2340

gaagtgtaag aaacacactg aggcagggaa gtccccaggc cccaggaagc cgtgccctgc   2400

ccccgtgagg atgtcactca gatggaaccg caggaagctg ctccgtgctt gtttgctcac   2460

ctggggtgtg ggaggcccgt ccggcagttc tgggtgctcc ctaccacctc cccagccttt   2520

gatcaggtgg ggagtcaggg acccctgccc ttgtcccact caagccaagc agccaagctc   2580

cttgggaggc cccactgggg aaataacagc tgtggctcac gtgagagtgt cttcacggca   2640

ggacaacgag gaagccctaa gacgtccctt ttttctctga gtatctcctc gcaagctggg   2700

taatcgatgg gggagtctga agcagatgca aagaggcaag aggctggatt ttgaattttc   2760

tttttaataa aaaggcacct ataaaacagg tcaatacagt acaggcagca cagagacccc   2820

cggaacaagc ctaaaaattg tttcaaaata aaaaccaaga agatgtcttc              2870


<210>  2881
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  2881


Met Ala Ser Phe Lys Ala Val Phe Val Pro Val Ala Tyr Ser Leu Ile 
1               5                   10                  15      


Phe Leu Leu Gly Val Ile Gly Asn Val Leu Val Leu Val Ile Leu Glu 
            20                  25                  30          


Arg His Arg Gln Thr Arg Ser Ser Thr Glu Thr Phe Leu Phe His Leu 
        35                  40                  45              


Ala Val Ala Asp Leu Leu Leu Val Phe Ile Leu Pro Phe Ala Val Ala 
    50                  55                  60                  


Glu Gly Ser Val Gly Trp Val Leu Gly Thr Phe Leu Cys Lys Thr Val 
65                  70                  75                  80  


Ile Ala Leu His Lys Val Asn Phe Tyr Cys Ser Ser Leu Leu Leu Ala 
                85                  90                  95      


Cys Ile Ala Val Asp Arg Tyr Leu Ala Ile Val His Ala Val His Ala 
            100                 105                 110         


Tyr Arg His Arg Arg Leu Leu Ser Ile His Ile Thr Cys Gly Thr Ile 
        115                 120                 125             


Trp Leu Val Gly Phe Leu Leu Ala Leu Pro Glu Ile Leu Phe Ala Lys 
    130                 135                 140                 


Val Ser Gln Gly His His Asn Asn Ser Leu Pro Arg Cys Thr Phe Ser 
145                 150                 155                 160 


Gln Glu Asn Gln Ala Glu Thr His Ala Trp Phe Thr Ser Arg Phe Leu 
                165                 170                 175     


Tyr His Val Ala Gly Phe Leu Leu Pro Met Leu Val Met Gly Trp Cys 
            180                 185                 190         


Tyr Val Gly Val Val His Arg Leu Arg Gln Ala Gln Arg Arg Pro Gln 
        195                 200                 205             


Arg Gln Lys Ala Val Arg Val Ala Ile Leu Val Thr Ser Ile Phe Phe 
    210                 215                 220                 


Leu Cys Trp Ser Pro Tyr His Ile Val Ile Phe Leu Asp Thr Leu Ala 
225                 230                 235                 240 


Arg Leu Lys Ala Val Asp Asn Thr Cys Lys Leu Asn Gly Ser Leu Pro 
                245                 250                 255     


Val Ala Ile Thr Met Cys Glu Phe Leu Gly Leu Ala His Cys Cys Leu 
            260                 265                 270         


Asn Pro Met Leu Tyr Thr Phe Ala Gly Val Lys Phe Arg Ser Asp Leu 
        275                 280                 285             


Ser Arg Leu Leu Thr Lys Leu Gly Cys Thr Gly Pro Ala Ser Leu Cys 
    290                 295                 300                 


Gln Leu Phe Pro Ser Trp Arg Arg Ser Ser Leu Ser Glu Ser Glu Asn 
305                 310                 315                 320 


Ala Thr Ser Leu Thr Thr Phe 
                325         

<210>  2882
<211>  4815
<212>  DNA
<213>  Homo sapiens

<400>  2882
aacgggtacc tgggtttggg ggcatgcaga gtatgcccat ggaggtgccc atgaatgcca     60

tgcagaggcc cgtgagacca ggcatgggct ggaccgaaga cttgccccct atggggggac    120

ccagcaattt tgcccagaac accatgccct acccaggtgg gcagggtgag gcggagcgat    180

tcatgactcc ccgggtccgt gaggagctgc tgcggcacca gctgctggag aagcggtcga    240

tgggcatgca gcgccccctg ggcatggcag gcagtggcat gggacagagc atggagatgg    300

agcggatgat gcaggcgcac cgacagatgg atcctgccat gtttcccggg cagatggctg    360

gtggtgaggg cctggcgggc actcccatgg gcatggagtt tggtggaggc cggggcctcc    420

tgagccctcc catggggcag tctgggctga gggaggtgga cccacccatg gggccaggca    480

acctcaacat gaacatgaat gtcaacatga acatgaacat gaacctgaac gtgcagatga    540

ccccgcagca gcagatgctg atgtcgcaga agatgcgggg ccctggggac ttgatggggc    600

cccagggcct cagtcctgag gagatggccc gggttcgggc ccagaacagc agtggcgtga    660

tgggcggccc gcagaagatg ctgatgcctt cacagtttcc caaccagggc cagcagggat    720

tctctggagg ccagggaccc taccaagcca tgtcccagga catgggcaat acccaagaca    780

tgttcagccc tgatcagagc tcaatgccca tgagcaacgt gggcaccacc cggctcagcc    840

acatgcctct gccccctgcg tccaatcctc ctgggaccgt gcattcagcc ccaaaccggg    900

ggctaggcag gcggccttcg gacctcacca tcagtattaa tcagatgggc tcaccgggca    960

tggggcactt gaagtcgccc acccttagcc aggtgcactc acccctggtc acctcgccct   1020

ctgccaacct caagtcaccc cagactccct cacagatggt gcccttgcct tctgccaacc   1080

cgccaggacc tctcaagtcg ccccaggtcc tcggctcctc cctcagtgtc cgttcaccca   1140

ctggctcgcc cagcaggctc aagtctcctt ccatggcggt gccttctcca ggctgggttg   1200

cctcacctaa gacggccatg cccagcccgg gggtctccca gaacaagcag ccgcctctca   1260

acatgaactc ttccaccacc ctgagcaaca tggaacaggg taccctcccg cctagcggcc   1320

cccggagcag ctcctcagca cctcccgcca accctcccag cggcctcatg aaccccagcc   1380

taccattcac ttcctcccca gaccccacac cttcccagaa ccccctgtca ctgatgatga   1440

cccagatgtc caagtacgcc atgcccagct ccaccccgct ctaccacaat gccatcaaga   1500

ccatcgccac ctcagacgac gagctgctgc ccgaccggcc cctgctgccc cccccaccac   1560

caccgcaggg ctccgggcca gggatcagca acagccagcc cagccagatg cacctgaact   1620

cagccgctgc ccagagccct atgggcatga acctgccagg ccagcagccc ctgtcccatg   1680

agcccccgcc cgccatgctg ccctccccca cccctctggg ctccaacatt ccactgcatc   1740

ccaacgcaca ggggacaggg gggccccctc aaaactccat gatgatggcc ccagggggcc   1800

ccgactccct gaatgccccc tgtggcccag tgcccagctc ctcccagatg atgcccttcc   1860

cccctcggct gcagcagccc catggtgcca tggctgggcg catgggcgac gcatacccac   1920

cgggtgtgct ccctggggtg gcatcagtgc tgaacgaccc cgagctgagc gaggtgatcc   1980

ggcccacccc aacggggatc cccgagttcg acttgtcgag gatcatcccc tctgagaagc   2040

caagcagcac cctccagtac ttccccaaga gcgagaacca gccccccaag gctcagcccc   2100

ctaatctgca tctcatgaac ctgcagaaca tgatggcgga gcagactccc tctcggcctc   2160

ccaacctccc aggccagcag ggcgtccagc gggggctcaa catgtccatg tgccaccctg   2220

gacagatgtc cttgctgggc aggacaggcg tgcccccaca gcaggggatg gtgccccatg   2280

gcctgcacca gggggtcatg tcccctccac aaggcctcat gacccagcag aatttcatgc   2340

tgatgaagca gcggggcgtg gggggcgagg tctacagcca gccgccccac atgctctccc   2400

cgcagggctc cctcatgggc cccccgcccc agcagaacct catggtgtcc cacccccttc   2460

ggcagcgcag tgtgtccctg gacagccaga tgggctacct cccggcacca ggcggcatgg   2520

ccaacctgcc cttctagaag tcgctgccag ggctggagcc ggggcaatgt tgcaaatacg   2580

ataaccttaa caaagttctt cccctcaatg ttgggatggc ctgggtcgcg gggtggggtg   2640

gagggggtgg gagggggctt gtgtagggag tggcatttgt ggaaaccaga tgtgctggca   2700

gcttaggggg aagtggcagt gtggggtggg ggattttgca ttggggttgg ttccatttcg   2760

gccaccagga ctgcccctcc cccactcctc ccaattccta tggagcctct ctattttacc   2820

tctttccgtg catccctgca cccgccacac ccccttcagc tatgcttttg gagtcctgga   2880

tgggaatctg gggggagaga ggaaggacag gtcaggtctc ccccagcccc ttctgctcct   2940

gtctcctcgt gtccgcattg ctggagctcc acctccctct tggtttctcc gcacccgccc   3000

attttccttc tgtctttacc tgcttcgtat cctttccctg ctgatgtggc tgacccctct   3060

cccacccctc cctgcaggcg gctggccagg tgggcaggtg ccagccggag ctgtaaatag   3120

agcgctgcgc ttttgtgctg gtttgtgcgt gtgctgtatt tctgtgtttt gatagaagtc   3180

acacaaaaaa aaaaggataa aagaaaccct tccccccttc ttcaagttat tgctccctcc   3240

attcccctgg acccagggac atgcagccct acatggccac ccactgtttg cagtgtctct   3300

gggtccctaa gggataccat tcctgtctcg tccccaaatg gtaagatgac gtaaatgacc   3360

cactcctaaa ctgaggtcag accacctagg cttccacctg gtgagcccta gcagggctga   3420

gacccccagg gcggcagcct gtctgctgct gagtgattca gggagaacat gtgtgcacgt   3480

gcatgtgtgt ttgcccacac cggtgacacg gggccctggc tttccacttt ggatgcccgg   3540

gcatccgctg ctgctacatc ttagccagaa cttgaagtct tttgtcccag tttgggatga   3600

aggaaaggag gaagaggcgg tggctgtgtg gcccccttga gtggagccat ggaaggggtg   3660

gcatggtgcc actggggcct gtggctgtag tagccctggg ccaggtaacc tccagggccc   3720

tgacttttcc agaggctgct gccacctact tcttatcaaa gaagggggag aacagttcat   3780

ctgagtcagt gcacctcccc tccagtctcc actccctgag gatggaatcg gggaaacagc   3840

atcctgccgc ctcctctctg cctgcccact caccggcaag gttgtccctc tgcccagggc   3900

tcagggccat gtaccagatc tgtctgtgcc cacccaggca cagccactgc ctcccccttg   3960

gctccctgct cctacccagg agagctccct atccgccttt ggtcagagct gaagccatat   4020

acgactgggt gtttgtcccc ctactttggc cccaggagta aaaaaacttc tccttttctc   4080

acttcctttc ctgcctcggg aggtggcagg gcagttccct ggctgaggcc ttttgcgccc   4140

cacctccagg accaagggcc attctagaca gggtgtcttc taccaggacc cgtccctagc   4200

cttcctggcc tggagggcct ggtcttgcac tggcagctgt aatacaaagg gaactcgccc   4260

cacttctccc agcctggtgc tgtcctctcg gcccaccatc ggccaggtcc agcgcttcct   4320

ctggggctga caacaggccc ctgactcacc ccggtcacct cccagggtcc atggccaggg   4380

cctctgtgtt tggggggcca cttgcccttc atcctgccag gcgctttgcc cgccctgcct   4440

cagcctgggc cctgtgccct tgagccctcc acccctggcc caagaccccc ccaaactgtc   4500

tgactctgtg tttcctgccc tgaggagaga ggggtcagat tgcagcgggc cgagtgccct   4560

ctccgtcccc tctcctccca cccacgccac aggccagcct actcttccct ccatccatgg   4620

ccacaccccc agccattttg taccattata taaatatata tataaatata aatatataaa   4680

tacaatatgt gaagacatct tcttggtttt tattttgaaa caatttttag gcttgttccg   4740

ggggtctctg tgctgcctgt actgtattga cctgttttat aggtgccttt ttattaaaaa   4800

gaaaattcaa aatcc                                                    4815


<210>  2883
<211>  837
<212>  PRT
<213>  Homo sapiens

<400>  2883


Met Gln Ser Met Pro Met Glu Val Pro Met Asn Ala Met Gln Arg Pro 
1               5                   10                  15      


Val Arg Pro Gly Met Gly Trp Thr Glu Asp Leu Pro Pro Met Gly Gly 
            20                  25                  30          


Pro Ser Asn Phe Ala Gln Asn Thr Met Pro Tyr Pro Gly Gly Gln Gly 
        35                  40                  45              


Glu Ala Glu Arg Phe Met Thr Pro Arg Val Arg Glu Glu Leu Leu Arg 
    50                  55                  60                  


His Gln Leu Leu Glu Lys Arg Ser Met Gly Met Gln Arg Pro Leu Gly 
65                  70                  75                  80  


Met Ala Gly Ser Gly Met Gly Gln Ser Met Glu Met Glu Arg Met Met 
                85                  90                  95      


Gln Ala His Arg Gln Met Asp Pro Ala Met Phe Pro Gly Gln Met Ala 
            100                 105                 110         


Gly Gly Glu Gly Leu Ala Gly Thr Pro Met Gly Met Glu Phe Gly Gly 
        115                 120                 125             


Gly Arg Gly Leu Leu Ser Pro Pro Met Gly Gln Ser Gly Leu Arg Glu 
    130                 135                 140                 


Val Asp Pro Pro Met Gly Pro Gly Asn Leu Asn Met Asn Met Asn Val 
145                 150                 155                 160 


Asn Met Asn Met Asn Met Asn Leu Asn Val Gln Met Thr Pro Gln Gln 
                165                 170                 175     


Gln Met Leu Met Ser Gln Lys Met Arg Gly Pro Gly Asp Leu Met Gly 
            180                 185                 190         


Pro Gln Gly Leu Ser Pro Glu Glu Met Ala Arg Val Arg Ala Gln Asn 
        195                 200                 205             


Ser Ser Gly Val Met Gly Gly Pro Gln Lys Met Leu Met Pro Ser Gln 
    210                 215                 220                 


Phe Pro Asn Gln Gly Gln Gln Gly Phe Ser Gly Gly Gln Gly Pro Tyr 
225                 230                 235                 240 


Gln Ala Met Ser Gln Asp Met Gly Asn Thr Gln Asp Met Phe Ser Pro 
                245                 250                 255     


Asp Gln Ser Ser Met Pro Met Ser Asn Val Gly Thr Thr Arg Leu Ser 
            260                 265                 270         


His Met Pro Leu Pro Pro Ala Ser Asn Pro Pro Gly Thr Val His Ser 
        275                 280                 285             


Ala Pro Asn Arg Gly Leu Gly Arg Arg Pro Ser Asp Leu Thr Ile Ser 
    290                 295                 300                 


Ile Asn Gln Met Gly Ser Pro Gly Met Gly His Leu Lys Ser Pro Thr 
305                 310                 315                 320 


Leu Ser Gln Val His Ser Pro Leu Val Thr Ser Pro Ser Ala Asn Leu 
                325                 330                 335     


Lys Ser Pro Gln Thr Pro Ser Gln Met Val Pro Leu Pro Ser Ala Asn 
            340                 345                 350         


Pro Pro Gly Pro Leu Lys Ser Pro Gln Val Leu Gly Ser Ser Leu Ser 
        355                 360                 365             


Val Arg Ser Pro Thr Gly Ser Pro Ser Arg Leu Lys Ser Pro Ser Met 
    370                 375                 380                 


Ala Val Pro Ser Pro Gly Trp Val Ala Ser Pro Lys Thr Ala Met Pro 
385                 390                 395                 400 


Ser Pro Gly Val Ser Gln Asn Lys Gln Pro Pro Leu Asn Met Asn Ser 
                405                 410                 415     


Ser Thr Thr Leu Ser Asn Met Glu Gln Gly Thr Leu Pro Pro Ser Gly 
            420                 425                 430         


Pro Arg Ser Ser Ser Ser Ala Pro Pro Ala Asn Pro Pro Ser Gly Leu 
        435                 440                 445             


Met Asn Pro Ser Leu Pro Phe Thr Ser Ser Pro Asp Pro Thr Pro Ser 
    450                 455                 460                 


Gln Asn Pro Leu Ser Leu Met Met Thr Gln Met Ser Lys Tyr Ala Met 
465                 470                 475                 480 


Pro Ser Ser Thr Pro Leu Tyr His Asn Ala Ile Lys Thr Ile Ala Thr 
                485                 490                 495     


Ser Asp Asp Glu Leu Leu Pro Asp Arg Pro Leu Leu Pro Pro Pro Pro 
            500                 505                 510         


Pro Pro Gln Gly Ser Gly Pro Gly Ile Ser Asn Ser Gln Pro Ser Gln 
        515                 520                 525             


Met His Leu Asn Ser Ala Ala Ala Gln Ser Pro Met Gly Met Asn Leu 
    530                 535                 540                 


Pro Gly Gln Gln Pro Leu Ser His Glu Pro Pro Pro Ala Met Leu Pro 
545                 550                 555                 560 


Ser Pro Thr Pro Leu Gly Ser Asn Ile Pro Leu His Pro Asn Ala Gln 
                565                 570                 575     


Gly Thr Gly Gly Pro Pro Gln Asn Ser Met Met Met Ala Pro Gly Gly 
            580                 585                 590         


Pro Asp Ser Leu Asn Ala Pro Cys Gly Pro Val Pro Ser Ser Ser Gln 
        595                 600                 605             


Met Met Pro Phe Pro Pro Arg Leu Gln Gln Pro His Gly Ala Met Ala 
    610                 615                 620                 


Gly Arg Met Gly Asp Ala Tyr Pro Pro Gly Val Leu Pro Gly Val Ala 
625                 630                 635                 640 


Ser Val Leu Asn Asp Pro Glu Leu Ser Glu Val Ile Arg Pro Thr Pro 
                645                 650                 655     


Thr Gly Ile Pro Glu Phe Asp Leu Ser Arg Ile Ile Pro Ser Glu Lys 
            660                 665                 670         


Pro Ser Ser Thr Leu Gln Tyr Phe Pro Lys Ser Glu Asn Gln Pro Pro 
        675                 680                 685             


Lys Ala Gln Pro Pro Asn Leu His Leu Met Asn Leu Gln Asn Met Met 
    690                 695                 700                 


Ala Glu Gln Thr Pro Ser Arg Pro Pro Asn Leu Pro Gly Gln Gln Gly 
705                 710                 715                 720 


Val Gln Arg Gly Leu Asn Met Ser Met Cys His Pro Gly Gln Met Ser 
                725                 730                 735     


Leu Leu Gly Arg Thr Gly Val Pro Pro Gln Gln Gly Met Val Pro His 
            740                 745                 750         


Gly Leu His Gln Gly Val Met Ser Pro Pro Gln Gly Leu Met Thr Gln 
        755                 760                 765             


Gln Asn Phe Met Leu Met Lys Gln Arg Gly Val Gly Gly Glu Val Tyr 
    770                 775                 780                 


Ser Gln Pro Pro His Met Leu Ser Pro Gln Gly Ser Leu Met Gly Pro 
785                 790                 795                 800 


Pro Pro Gln Gln Asn Leu Met Val Ser His Pro Leu Arg Gln Arg Ser 
                805                 810                 815     


Val Ser Leu Asp Ser Gln Met Gly Tyr Leu Pro Ala Pro Gly Gly Met 
            820                 825                 830         


Ala Asn Leu Pro Phe 
        835         

<210>  2884
<211>  4437
<212>  DNA
<213>  Homo sapiens

<400>  2884
gaggaaccct tgcagtccat gatttcacag acacagagcc tagggggccc cccgctggag     60

catgaagtgc ctgggcaccc cccgggtggg gacatggggc agcagatgaa catgatgata    120

cagaggctgg gccaggacag cctcacgcct gagcaggtgg cctggcgcaa gctgcaggag    180

gagtactacg aagagaaacg gcggaaagag gaacagattg ggctgcatgg gagccgtcct    240

ctgcaggaca tgatgggcat ggggggcatg atggtgaggg ggcccccgcc tccttaccac    300

agcaagcctg gggatcagtg gccacctgga atgggtgcgc agctgcgggg gcccatggat    360

gttcaagatc ccatgcagct ccggggcgga cctccctttc ctgggccccg tttcccaggc    420

aaccagatac aacgggtacc tgggtttggg ggcatgcaga gtatgcccat ggaggtgccc    480

atgaatgcca tgcagaggcc cgtgagacca ggcatgggct ggaccgaaga cttgccccct    540

atggggggac ccagcaattt tgcccagaac accatgccct acccaggtgg gcagggtgag    600

gcggagcgat tcatgactcc ccgggtccgt gaggagctgc tgcggcacca gctgctggag    660

aagcggtcga tgggcatgca gcgccccctg ggcatggcag gcagtggcat gggacagagc    720

atggagatgg agcggatgat gcaggcgcac cgacagatgg atcctgccat gtttcccggg    780

cagatggctg gtggtgaggg cctggcgggc actcccatgg gcatggagtt tggtggaggc    840

cggggcctcc tgagccctcc catggggcag tctgggctga gggaggtgga cccacccatg    900

gggccaggca acctcaacat gaacatgaat gtcaacatga acatgaacat gaacctgaac    960

gtgcagatga ccccgcagca gcagatgctg atgtcgcaga agatgcgggg ccctggggac   1020

ttgatggggc cccagggcct cagtcctgag gagatggccc gggttcgggc ccagaacagc   1080

agtggcgtga tgggcggccc gcagaagatg ctgatgcctt cacagtttcc caaccagggc   1140

cagcagggat tctctggagg ccagggaccc taccaagcca tgtcccagga catgggcaat   1200

acccaagaca tgttcagccc tgatcagagc tcaatgccca tgagcaacgt gggcaccacc   1260

cggctcagcc acatgcctct gccccctgcg tccaatcctc ctgggaccgt gcattcagcc   1320

ccaaaccggg ggctaggcag gcggccttcg gacctcacca tcagtattaa tcagatgggc   1380

tcaccgggca tggggcactt gaagtcgccc acccttagcc aggtgcactc acccctggtc   1440

acctcgccct ctgccaacct caagtcaccc cagactccct cacagatggt gcccttgcct   1500

tctgccaacc cgccaggacc tctcaagtcg ccccaggtcc tcggctcctc cctcagtgtc   1560

cgttcaccca ctggctcgcc cagcaggctc aagtctcctt ccatggcggt gccttctcca   1620

ggctgggttg cctcacctaa gacggccatg cccagcccgg gggtctccca gaacaagcag   1680

ccgcctctca acatgaactc ttccaccacc ctgagcaaca tggaacaggg taccctcccg   1740

cctagcggcc cccggagcag ctcctcagca cctcccgcca accctcccag cggcctcatg   1800

aaccccagcc taccattcac ttcctcccca gaccccacac cttcccagaa ccccctgtca   1860

ctgatgatga cccagatgtc caagtacgcc atgcccagct ccaccccgct ctaccacaat   1920

gccatcaaga ccatcgccac ctcagacgac gagctgctgc ccgaccggcc cctgctgccc   1980

cccccaccac caccgcaggg ctccgggcca gggatcagca acagccagcc cagccagatg   2040

cacctgaact cagccgctgc ccagagccct atgggcatga acctgccagg ccagcagccc   2100

ctgtcccatg agcccccgcc cgccatgctg ccctccccca cccctctggg ctccaacatt   2160

ccactgcatc ccaacgcaca ggggacaggg gggccccctc aaaactccat gatgatggcc   2220

ccagggggcc ccgactccct gaatgccccc tgtggcccag tgcccagctc ctcccagatg   2280

atgcccttcc cccctcggct gcagcagccc catggtgcca tggcccccac tgggggtggg   2340

ggcggggggc ctggcctgca gcagcactac ccgtcaggca tggccctgcc tcccgaggac   2400

ctgcccaacc agccgccagg ccccatgcct ccccagcagc acctgatggg caaagccatg   2460

gctgggcgca tgggcgacgc atacccaccg ggtgtgctcc ctggggtggc atcagtgctg   2520

aacgaccccg agctgagcga ggtgatccgg cccaccccaa cggggatccc cgagttcgac   2580

ttgtcgagga tcatcccctt cttggtttct ccgcacccgc ccattttcct tctgtcttta   2640

cctgcttcgt atcctttccc tgctgatgtg gctgacccct ctcccacccc tccctgcagg   2700

cggctggcca ggtgggcagg tgccagccgg agctgtaaat agagcgctgc gcttttgtgc   2760

tggtttgtgc gtgtgctgta tttctgtgtt ttgatagaag tcacacaaaa aaaaaaggat   2820

aaaagaaacc cttcccccct tcttcaagtt attgctccct ccattcccct ggacccaggg   2880

acatgcagcc ctacatggcc acccactgtt tgcagtgtct ctgggtccct aagggatacc   2940

attcctgtct cgtccccaaa tggtaagatg acgtaaatga cccactccta aactgaggtc   3000

agaccaccta ggcttccacc tggtgagccc tagcagggct gagaccccca gggcggcagc   3060

ctgtctgctg ctgagtgatt cagggagaac atgtgtgcac gtgcatgtgt gtttgcccac   3120

accggtgaca cggggccctg gctttccact ttggatgccc gggcatccgc tgctgctaca   3180

tcttagccag aacttgaagt cttttgtccc agtttgggat gaaggaaagg aggaagaggc   3240

ggtggctgtg tggccccctt gagtggagcc atggaagggg tggcatggtg ccactggggc   3300

ctgtggctgt agtagccctg ggccaggtaa cctccagggc cctgactttt ccagaggctg   3360

ctgccaccta cttcttatca aagaaggggg agaacagttc atctgagtca gtgcacctcc   3420

cctccagtct ccactccctg aggatggaat cggggaaaca gcatcctgcc gcctcctctc   3480

tgcctgccca ctcaccggca aggttgtccc tctgcccagg gctcagggcc atgtaccaga   3540

tctgtctgtg cccacccagg cacagccact gcctccccct tggctccctg ctcctaccca   3600

ggagagctcc ctatccgcct ttggtcagag ctgaagccat atacgactgg gtgtttgtcc   3660

ccctactttg gccccaggag taaaaaaact tctccttttc tcacttcctt tcctgcctcg   3720

ggaggtggca gggcagttcc ctggctgagg ccttttgcgc cccacctcca ggaccaaggg   3780

ccattctaga cagggtgtct tctaccagga cccgtcccta gccttcctgg cctggagggc   3840

ctggtcttgc actggcagct gtaatacaaa gggaactcgc cccacttctc ccagcctggt   3900

gctgtcctct cggcccacca tcggccaggt ccagcgcttc ctctggggct gacaacaggc   3960

ccctgactca ccccggtcac ctcccagggt ccatggccag ggcctctgtg tttggggggc   4020

cacttgccct tcatcctgcc aggcgctttg cccgccctgc ctcagcctgg gccctgtgcc   4080

cttgagccct ccacccctgg cccaagaccc ccccaaactg tctgactctg tgtttcctgc   4140

cctgaggaga gaggggtcag attgcagcgg gccgagtgcc ctctccgtcc cctctcctcc   4200

cacccacgcc acaggccagc ctactcttcc ctccatccat ggccacaccc ccagccattt   4260

tgtaccatta tataaatata tatataaata taaatatata aatacaatat gtgaagacat   4320

cttcttggtt tttattttga aacaattttt aggcttgttc cgggggtctc tgtgctgcct   4380

gtactgtatt gacctgtttt ataggtgcct ttttattaaa aagaaaattc aaaatcc      4437


<210>  2885
<211>  907
<212>  PRT
<213>  Homo sapiens

<400>  2885


Met Ile Ser Gln Thr Gln Ser Leu Gly Gly Pro Pro Leu Glu His Glu 
1               5                   10                  15      


Val Pro Gly His Pro Pro Gly Gly Asp Met Gly Gln Gln Met Asn Met 
            20                  25                  30          


Met Ile Gln Arg Leu Gly Gln Asp Ser Leu Thr Pro Glu Gln Val Ala 
        35                  40                  45              


Trp Arg Lys Leu Gln Glu Glu Tyr Tyr Glu Glu Lys Arg Arg Lys Glu 
    50                  55                  60                  


Glu Gln Ile Gly Leu His Gly Ser Arg Pro Leu Gln Asp Met Met Gly 
65                  70                  75                  80  


Met Gly Gly Met Met Val Arg Gly Pro Pro Pro Pro Tyr His Ser Lys 
                85                  90                  95      


Pro Gly Asp Gln Trp Pro Pro Gly Met Gly Ala Gln Leu Arg Gly Pro 
            100                 105                 110         


Met Asp Val Gln Asp Pro Met Gln Leu Arg Gly Gly Pro Pro Phe Pro 
        115                 120                 125             


Gly Pro Arg Phe Pro Gly Asn Gln Ile Gln Arg Val Pro Gly Phe Gly 
    130                 135                 140                 


Gly Met Gln Ser Met Pro Met Glu Val Pro Met Asn Ala Met Gln Arg 
145                 150                 155                 160 


Pro Val Arg Pro Gly Met Gly Trp Thr Glu Asp Leu Pro Pro Met Gly 
                165                 170                 175     


Gly Pro Ser Asn Phe Ala Gln Asn Thr Met Pro Tyr Pro Gly Gly Gln 
            180                 185                 190         


Gly Glu Ala Glu Arg Phe Met Thr Pro Arg Val Arg Glu Glu Leu Leu 
        195                 200                 205             


Arg His Gln Leu Leu Glu Lys Arg Ser Met Gly Met Gln Arg Pro Leu 
    210                 215                 220                 


Gly Met Ala Gly Ser Gly Met Gly Gln Ser Met Glu Met Glu Arg Met 
225                 230                 235                 240 


Met Gln Ala His Arg Gln Met Asp Pro Ala Met Phe Pro Gly Gln Met 
                245                 250                 255     


Ala Gly Gly Glu Gly Leu Ala Gly Thr Pro Met Gly Met Glu Phe Gly 
            260                 265                 270         


Gly Gly Arg Gly Leu Leu Ser Pro Pro Met Gly Gln Ser Gly Leu Arg 
        275                 280                 285             


Glu Val Asp Pro Pro Met Gly Pro Gly Asn Leu Asn Met Asn Met Asn 
    290                 295                 300                 


Val Asn Met Asn Met Asn Met Asn Leu Asn Val Gln Met Thr Pro Gln 
305                 310                 315                 320 


Gln Gln Met Leu Met Ser Gln Lys Met Arg Gly Pro Gly Asp Leu Met 
                325                 330                 335     


Gly Pro Gln Gly Leu Ser Pro Glu Glu Met Ala Arg Val Arg Ala Gln 
            340                 345                 350         


Asn Ser Ser Gly Val Met Gly Gly Pro Gln Lys Met Leu Met Pro Ser 
        355                 360                 365             


Gln Phe Pro Asn Gln Gly Gln Gln Gly Phe Ser Gly Gly Gln Gly Pro 
    370                 375                 380                 


Tyr Gln Ala Met Ser Gln Asp Met Gly Asn Thr Gln Asp Met Phe Ser 
385                 390                 395                 400 


Pro Asp Gln Ser Ser Met Pro Met Ser Asn Val Gly Thr Thr Arg Leu 
                405                 410                 415     


Ser His Met Pro Leu Pro Pro Ala Ser Asn Pro Pro Gly Thr Val His 
            420                 425                 430         


Ser Ala Pro Asn Arg Gly Leu Gly Arg Arg Pro Ser Asp Leu Thr Ile 
        435                 440                 445             


Ser Ile Asn Gln Met Gly Ser Pro Gly Met Gly His Leu Lys Ser Pro 
    450                 455                 460                 


Thr Leu Ser Gln Val His Ser Pro Leu Val Thr Ser Pro Ser Ala Asn 
465                 470                 475                 480 


Leu Lys Ser Pro Gln Thr Pro Ser Gln Met Val Pro Leu Pro Ser Ala 
                485                 490                 495     


Asn Pro Pro Gly Pro Leu Lys Ser Pro Gln Val Leu Gly Ser Ser Leu 
            500                 505                 510         


Ser Val Arg Ser Pro Thr Gly Ser Pro Ser Arg Leu Lys Ser Pro Ser 
        515                 520                 525             


Met Ala Val Pro Ser Pro Gly Trp Val Ala Ser Pro Lys Thr Ala Met 
    530                 535                 540                 


Pro Ser Pro Gly Val Ser Gln Asn Lys Gln Pro Pro Leu Asn Met Asn 
545                 550                 555                 560 


Ser Ser Thr Thr Leu Ser Asn Met Glu Gln Gly Thr Leu Pro Pro Ser 
                565                 570                 575     


Gly Pro Arg Ser Ser Ser Ser Ala Pro Pro Ala Asn Pro Pro Ser Gly 
            580                 585                 590         


Leu Met Asn Pro Ser Leu Pro Phe Thr Ser Ser Pro Asp Pro Thr Pro 
        595                 600                 605             


Ser Gln Asn Pro Leu Ser Leu Met Met Thr Gln Met Ser Lys Tyr Ala 
    610                 615                 620                 


Met Pro Ser Ser Thr Pro Leu Tyr His Asn Ala Ile Lys Thr Ile Ala 
625                 630                 635                 640 


Thr Ser Asp Asp Glu Leu Leu Pro Asp Arg Pro Leu Leu Pro Pro Pro 
                645                 650                 655     


Pro Pro Pro Gln Gly Ser Gly Pro Gly Ile Ser Asn Ser Gln Pro Ser 
            660                 665                 670         


Gln Met His Leu Asn Ser Ala Ala Ala Gln Ser Pro Met Gly Met Asn 
        675                 680                 685             


Leu Pro Gly Gln Gln Pro Leu Ser His Glu Pro Pro Pro Ala Met Leu 
    690                 695                 700                 


Pro Ser Pro Thr Pro Leu Gly Ser Asn Ile Pro Leu His Pro Asn Ala 
705                 710                 715                 720 


Gln Gly Thr Gly Gly Pro Pro Gln Asn Ser Met Met Met Ala Pro Gly 
                725                 730                 735     


Gly Pro Asp Ser Leu Asn Ala Pro Cys Gly Pro Val Pro Ser Ser Ser 
            740                 745                 750         


Gln Met Met Pro Phe Pro Pro Arg Leu Gln Gln Pro His Gly Ala Met 
        755                 760                 765             


Ala Pro Thr Gly Gly Gly Gly Gly Gly Pro Gly Leu Gln Gln His Tyr 
    770                 775                 780                 


Pro Ser Gly Met Ala Leu Pro Pro Glu Asp Leu Pro Asn Gln Pro Pro 
785                 790                 795                 800 


Gly Pro Met Pro Pro Gln Gln His Leu Met Gly Lys Ala Met Ala Gly 
                805                 810                 815     


Arg Met Gly Asp Ala Tyr Pro Pro Gly Val Leu Pro Gly Val Ala Ser 
            820                 825                 830         


Val Leu Asn Asp Pro Glu Leu Ser Glu Val Ile Arg Pro Thr Pro Thr 
        835                 840                 845             


Gly Ile Pro Glu Phe Asp Leu Ser Arg Ile Ile Pro Phe Leu Val Ser 
    850                 855                 860                 


Pro His Pro Pro Ile Phe Leu Leu Ser Leu Pro Ala Ser Tyr Pro Phe 
865                 870                 875                 880 


Pro Ala Asp Val Ala Asp Pro Ser Pro Thr Pro Pro Cys Arg Arg Leu 
                885                 890                 895     


Ala Arg Trp Ala Gly Ala Ser Arg Ser Cys Lys 
            900                 905         

<210>  2886
<211>  7743
<212>  DNA
<213>  Homo sapiens

<400>  2886
cgtgcgtgtc ttgtctccct gtccacgtgt gagctgtgag tgtgtgtgag tcagagttcg     60

ggtgtctgtg ggtctctgag cctctgctgg cagcacccgg ggctcgccaa gctcttgccg    120

gctggcgcgc gcccagcccc tggcgggact tgtccgtgtg tctgtccgcg cgcggggcct    180

ggagaagcac gctgcagtcc tgtccgcctc ccgctcgctg cctcgctggc tgtcgctcgc    240

tcgctctgcc tctccgcccg ggctctgccg aagggggcgg ggtgggggtg cagggcgggg    300

ggaggggagg ctcctgcatt cttgcggtcg gggaggaatc cgagccagcg ttactggtct    360

ccagaagagc ccagctgcag ccccggggcc ccgccaggcc tctcgctgcc cgcccgggcc    420

tgctgggatg ggcacgggct aggcctcgag ctggggacgg ggcggggcgt ggccccaacc    480

ccgggccccc tccacggctg gagcgctctg ggggtggggc acgaggggta ccccaccctg    540

ggtgaggggc gcgtctggga gcaggaatcc ctcagggggc caggggagac ctcacagccg    600

ccccacacgg cacctttgct acctagcctt ttagtgaatt ctgtctctgc cgcccgtcgg    660

ggcggaggct tgctggagac tgcaagcccc ctgagggcaa ggtgcgggag ggatggggac    720

agggctggcc tccaggatcg agaccccatc tcgtaatcct ctttttccag tgccacccca    780

ccctatccag ctccctagtc ccagggctgt tgggtcctcc cttctcccct ccccctctga    840

caccccctcc ccaagtcacg agttttctct ttggggcttg ttgctgcagt ccgtgctcca    900

gtaccgagta cctggctggg ccctgggcac gcacaggggc cgtagcccca ctgtgtgtgg    960

gagccatgag gatcctggct aacaagacaa ggttacccca ccccaggagg agagaagctc   1020

cagggagccc gccgctgtcc ccccgcggtc attgcccccc tgccccagcc aagccaatgc   1080

acccagaaaa taaattgacc aatcatggca agacagggaa tggcggggcc caatctcagc   1140

accagaatgt gaaccaagga cccacctgca acgtgggctc gaagggcgtg ggggcgggga   1200

accatggggc caaggccaac cagatctcgc ctagcaactc aagtctgaag aacccccagg   1260

caggggtgcc ccctttcagc tcgctcaagg gcaaggtgaa gagggaccgg agtgtgtctg   1320

tggactctgg agagcagcga gaggctggga ccccatccct ggattcagag gccaaagagg   1380

tggcgccgcg gagtaagcgg cgctgtgtgc tggagcggaa gcagccgtac agtggggacg   1440

aatggtgctc tggaccggac agtgaggagg acgacaagcc cattggggcc acccacaatt   1500

gtaatgtagc agacccagcc atggcggccc cacagctggg tcccggccaa accacccaac   1560

tgcccctcag cgagagcagc gtgccaggcg ccccgcacgg ccctcctcct ggccttcggc   1620

ctgatgcccc tgggggcggg ggcgggggcg ggggcgtccc cggaaagcct ccctcgcagt   1680

tcgtatatgt cttcaccacc cacctggcca acacggctgc agaggcagtg ctgcagggcc   1740

gggccgactc catcctcgcc taccaccagc agaacgtgcc ccgggccaag cttgaccagg   1800

cccctaaagt gccccccacc ccagaaccgc tacccctgag cacgccgtca gcaggcaccc   1860

cgcagtccca gccacctcca ctgccgccgc cgccaccccc ggcccctggc agtgccccgc   1920

ctgctctgcc cccagagggg cctcctgagg acagcagtca ggacctggcc cccaactcgg   1980

tgggagctgc cagcacaggt ggtgggactg ggggcaccca ccctaacacc ccgacggcta   2040

ccaccgccaa caaccctctg cctcctggag gagaccccag cagtgccccc ggccctgccc   2100

tgctggggga ggcagccgcc cctggaaatg ggcagcgcag cctggtgggc tcagagggct   2160

tgtccaaaga gcagctggag catcgggaac ggtccctcca gacgctgcga gacattgagc   2220

gactgctgct ccgcagcgga gagactgagc ccttcctcaa ggggccccca ggaggagcgg   2280

gtgagggggg cccaccagca caagcccccc ctccccccca gcagccaccc acggcccctc   2340

ccagcgggct gaagaaatat gaggaaccct tgcagtccat gatttcacag acacagagcc   2400

tagggggccc cccgctggag catgaagtgc ctgggcaccc cccgggtggg gacatggggc   2460

agcagatgaa catgatgata cagaggctgg gccaggacag cctcacgcct gagcaggtgg   2520

cctggcgcaa gctgcaggag gagtactacg aagagaaacg gcggaaagag gaacagattg   2580

ggctgcatgg gagccgtcct ctgcaggaca tgatgggcat ggggggcatg atggtgaggg   2640

ggcccccgcc tccttaccac agcaagcctg gggatcagtg gccacctgga atgggtgcgc   2700

agctgcgggg gcccatggat gttcaagatc ccatgcagct ccggggcgga cctccctttc   2760

ctgggccccg tttcccaggc aaccagatac aacgggtacc tgggtttggg ggcatgcaga   2820

gtatgcccat ggaggtgccc atgaatgcca tgcagaggcc cgtgagacca ggcatgggct   2880

ggaccgaaga cttgccccct atggggggac ccagcaattt tgcccagaac accatgccct   2940

acccaggtgg gcagggtgag gcggagcgat tcatgactcc ccgggtccgt gaggagctgc   3000

tgcggcacca gctgctggag aagcggtcga tgggcatgca gcgccccctg ggcatggcag   3060

gcagtggcat gggacagagc atggagatgg agcggatgat gcaggcgcac cgacagatgg   3120

atcctgccat gtttcccggg cagatggctg gtggtgaggg cctggcgggc actcccatgg   3180

gcatggagtt tggtggaggc cggggcctcc tgagccctcc catggggcag tctgggctga   3240

gggaggtgga cccacccatg gggccaggca acctcaacat gaacatgaat gtcaacatga   3300

acatgaacat gaacctgaac gtgcagatga ccccgcagca gcagatgctg atgtcgcaga   3360

agatgcgggg ccctggggac ttgatggggc cccagggcct cagtcctgag gagatggccc   3420

gggttcgggc ccagaacagc agtggcgtga tgggcggccc gcagaagatg ctgatgcctt   3480

cacagtttcc caaccagggc cagcagggat tctctggagg ccagggaccc taccaagcca   3540

tgtcccagga catgggcaat acccaagaca tgttcagccc tgatcagagc tcaatgccca   3600

tgagcaacgt gggcaccacc cggctcagcc acatgcctct gccccctgcg tccaatcctc   3660

ctgggaccgt gcattcagcc ccaaaccggg ggctaggcag gcggccttcg gacctcacca   3720

tcagtattaa tcagatgggc tcaccgggca tggggcactt gaagtcgccc acccttagcc   3780

aggtgcactc acccctggtc acctcgccct ctgccaacct caagtcaccc cagactccct   3840

cacagatggt gcccttgcct tctgccaacc cgccaggacc tctcaagtcg ccccaggtcc   3900

tcggctcctc cctcagtgtc cgttcaccca ctggctcgcc cagcaggctc aagtctcctt   3960

ccatggcggt gccttctcca ggctgggttg cctcacctaa gacggccatg cccagcccgg   4020

gggtctccca gaacaagcag ccgcctctca acatgaactc ttccaccacc ctgagcaaca   4080

tggaacaggg taccctcccg cctagcggcc cccggagcag ctcctcagca cctcccgcca   4140

accctcccag cggcctcatg aaccccagcc taccattcac ttcctcccca gaccccacac   4200

cttcccagaa ccccctgtca ctgatgatga cccagatgtc caagtacgcc atgcccagct   4260

ccaccccgct ctaccacaat gccatcaaga ccatcgccac ctcagacgac gagctgctgc   4320

ccgaccggcc cctgctgccc cccccaccac caccgcaggg ctccgggcca gggatcagca   4380

acagccagcc cagccagatg cacctgaact cagccgctgc ccagagccct atgggcatga   4440

acctgccagg ccagcagccc ctgtcccatg agcccccgcc cgccatgctg ccctccccca   4500

cccctctggg ctccaacatt ccactgcatc ccaacgcaca ggggacaggg gggccccctc   4560

aaaactccat gatgatggcc ccagggggcc ccgactccct gaatgccccc tgtggcccag   4620

tgcccagctc ctcccagatg atgcccttcc cccctcggct gcagcagccc catggtgcca   4680

tggcccccac tgggggtggg ggcggggggc ctggcctgca gcagcactac ccgtcaggca   4740

tggccctgcc tcccgaggac ctgcccaacc agccgccagg ccccatgcct ccccagcagc   4800

acctgatggg caaagccatg gctgggcgca tgggcgacgc atacccaccg ggtgtgctcc   4860

ctggggtggc atcagtgctg aacgaccccg agctgagcga ggtgatccgg cccaccccaa   4920

cggggatccc cgagttcgac ttgtcgagga tcatcccctc tgagaagcca agcagcaccc   4980

tccagtactt ccccaagagc gagaaccagc cccccaaggc tcagccccct aatctgcatc   5040

tcatgaacct gcagaacatg atggcggagc agactccctc tcggcctccc aacctcccag   5100

gccagcaggg cgtccagcgg gggctcaaca tgtccatgtg ccaccctgga cagatgtcct   5160

tgctgggcag gacaggcgtg cccccacagc aggggatggt gccccatggc ctgcaccagg   5220

gggtcatgtc ccctccacaa ggcctcatga cccagcagaa tttcatgctg atgaagcagc   5280

ggggcgtggg gggcgaggtc tacagccagc cgccccacat gctctccccg cagggctccc   5340

tcatgggccc cccgccccag cagaacctca tggtgtccca cccccttcgg cagcgcagtg   5400

tgtccctgga cagccagatg ggctacctcc cggcaccagg cggcatggcc aacctgccct   5460

tctagaagtc gctgccaggg ctggagccgg ggcaatgttg caaatacgat aaccttaaca   5520

aagttcttcc cctcaatgtt gggatggcct gggtcgcggg gtggggtgga gggggtggga   5580

gggggcttgt gtagggagtg gcatttgtgg aaaccagatg tgctggcagc ttagggggaa   5640

gtggcagtgt ggggtggggg attttgcatt ggggttggtt ccatttcggc caccaggact   5700

gcccctcccc cactcctccc aattcctatg gagcctctct attttacctc tttccgtgca   5760

tccctgcacc cgccacaccc ccttcagcta tgcttttgga gtcctggatg ggaatctggg   5820

gggagagagg aaggacaggt caggtctccc ccagcccctt ctgctcctgt ctcctcgtgt   5880

ccgcattgct ggagctccac ctccctcttg gtttctccgc acccgcccat tttccttctg   5940

tctttacctg cttcgtatcc tttccctgct gatgtggctg acccctctcc cacccctccc   6000

tgcaggcggc tggccaggtg ggcaggtgcc agccggagct gtaaatagag cgctgcgctt   6060

ttgtgctggt ttgtgcgtgt gctgtatttc tgtgttttga tagaagtcac acaaaaaaaa   6120

aaggataaaa gaaacccttc cccccttctt caagttattg ctccctccat tcccctggac   6180

ccagggacat gcagccctac atggccaccc actgtttgca gtgtctctgg gtccctaagg   6240

gataccattc ctgtctcgtc cccaaatggt aagatgacgt aaatgaccca ctcctaaact   6300

gaggtcagac cacctaggct tccacctggt gagccctagc agggctgaga cccccagggc   6360

ggcagcctgt ctgctgctga gtgattcagg gagaacatgt gtgcacgtgc atgtgtgttt   6420

gcccacaccg gtgacacggg gccctggctt tccactttgg atgcccgggc atccgctgct   6480

gctacatctt agccagaact tgaagtcttt tgtcccagtt tgggatgaag gaaaggagga   6540

agaggcggtg gctgtgtggc ccccttgagt ggagccatgg aaggggtggc atggtgccac   6600

tggggcctgt ggctgtagta gccctgggcc aggtaacctc cagggccctg acttttccag   6660

aggctgctgc cacctacttc ttatcaaaga agggggagaa cagttcatct gagtcagtgc   6720

acctcccctc cagtctccac tccctgagga tggaatcggg gaaacagcat cctgccgcct   6780

cctctctgcc tgcccactca ccggcaaggt tgtccctctg cccagggctc agggccatgt   6840

accagatctg tctgtgccca cccaggcaca gccactgcct cccccttggc tccctgctcc   6900

tacccaggag agctccctat ccgcctttgg tcagagctga agccatatac gactgggtgt   6960

ttgtccccct actttggccc caggagtaaa aaaacttctc cttttctcac ttcctttcct   7020

gcctcgggag gtggcagggc agttccctgg ctgaggcctt ttgcgcccca cctccaggac   7080

caagggccat tctagacagg gtgtcttcta ccaggacccg tccctagcct tcctggcctg   7140

gagggcctgg tcttgcactg gcagctgtaa tacaaaggga actcgcccca cttctcccag   7200

cctggtgctg tcctctcggc ccaccatcgg ccaggtccag cgcttcctct ggggctgaca   7260

acaggcccct gactcacccc ggtcacctcc cagggtccat ggccagggcc tctgtgtttg   7320

gggggccact tgcccttcat cctgccaggc gctttgcccg ccctgcctca gcctgggccc   7380

tgtgcccttg agccctccac ccctggccca agaccccccc aaactgtctg actctgtgtt   7440

tcctgccctg aggagagagg ggtcagattg cagcgggccg agtgccctct ccgtcccctc   7500

tcctcccacc cacgccacag gccagcctac tcttccctcc atccatggcc acacccccag   7560

ccattttgta ccattatata aatatatata taaatataaa tatataaata caatatgtga   7620

agacatcttc ttggttttta ttttgaaaca atttttaggc ttgttccggg ggtctctgtg   7680

ctgcctgtac tgtattgacc tgttttatag gtgccttttt attaaaaaga aaattcaaaa   7740

tcc                                                                 7743


<210>  2887
<211>  1499
<212>  PRT
<213>  Homo sapiens

<400>  2887


Met Arg Ile Leu Ala Asn Lys Thr Arg Leu Pro His Pro Arg Arg Arg 
1               5                   10                  15      


Glu Ala Pro Gly Ser Pro Pro Leu Ser Pro Arg Gly His Cys Pro Pro 
            20                  25                  30          


Ala Pro Ala Lys Pro Met His Pro Glu Asn Lys Leu Thr Asn His Gly 
        35                  40                  45              


Lys Thr Gly Asn Gly Gly Ala Gln Ser Gln His Gln Asn Val Asn Gln 
    50                  55                  60                  


Gly Pro Thr Cys Asn Val Gly Ser Lys Gly Val Gly Ala Gly Asn His 
65                  70                  75                  80  


Gly Ala Lys Ala Asn Gln Ile Ser Pro Ser Asn Ser Ser Leu Lys Asn 
                85                  90                  95      


Pro Gln Ala Gly Val Pro Pro Phe Ser Ser Leu Lys Gly Lys Val Lys 
            100                 105                 110         


Arg Asp Arg Ser Val Ser Val Asp Ser Gly Glu Gln Arg Glu Ala Gly 
        115                 120                 125             


Thr Pro Ser Leu Asp Ser Glu Ala Lys Glu Val Ala Pro Arg Ser Lys 
    130                 135                 140                 


Arg Arg Cys Val Leu Glu Arg Lys Gln Pro Tyr Ser Gly Asp Glu Trp 
145                 150                 155                 160 


Cys Ser Gly Pro Asp Ser Glu Glu Asp Asp Lys Pro Ile Gly Ala Thr 
                165                 170                 175     


His Asn Cys Asn Val Ala Asp Pro Ala Met Ala Ala Pro Gln Leu Gly 
            180                 185                 190         


Pro Gly Gln Thr Thr Gln Leu Pro Leu Ser Glu Ser Ser Val Pro Gly 
        195                 200                 205             


Ala Pro His Gly Pro Pro Pro Gly Leu Arg Pro Asp Ala Pro Gly Gly 
    210                 215                 220                 


Gly Gly Gly Gly Gly Gly Val Pro Gly Lys Pro Pro Ser Gln Phe Val 
225                 230                 235                 240 


Tyr Val Phe Thr Thr His Leu Ala Asn Thr Ala Ala Glu Ala Val Leu 
                245                 250                 255     


Gln Gly Arg Ala Asp Ser Ile Leu Ala Tyr His Gln Gln Asn Val Pro 
            260                 265                 270         


Arg Ala Lys Leu Asp Gln Ala Pro Lys Val Pro Pro Thr Pro Glu Pro 
        275                 280                 285             


Leu Pro Leu Ser Thr Pro Ser Ala Gly Thr Pro Gln Ser Gln Pro Pro 
    290                 295                 300                 


Pro Leu Pro Pro Pro Pro Pro Pro Ala Pro Gly Ser Ala Pro Pro Ala 
305                 310                 315                 320 


Leu Pro Pro Glu Gly Pro Pro Glu Asp Ser Ser Gln Asp Leu Ala Pro 
                325                 330                 335     


Asn Ser Val Gly Ala Ala Ser Thr Gly Gly Gly Thr Gly Gly Thr His 
            340                 345                 350         


Pro Asn Thr Pro Thr Ala Thr Thr Ala Asn Asn Pro Leu Pro Pro Gly 
        355                 360                 365             


Gly Asp Pro Ser Ser Ala Pro Gly Pro Ala Leu Leu Gly Glu Ala Ala 
    370                 375                 380                 


Ala Pro Gly Asn Gly Gln Arg Ser Leu Val Gly Ser Glu Gly Leu Ser 
385                 390                 395                 400 


Lys Glu Gln Leu Glu His Arg Glu Arg Ser Leu Gln Thr Leu Arg Asp 
                405                 410                 415     


Ile Glu Arg Leu Leu Leu Arg Ser Gly Glu Thr Glu Pro Phe Leu Lys 
            420                 425                 430         


Gly Pro Pro Gly Gly Ala Gly Glu Gly Gly Pro Pro Ala Gln Ala Pro 
        435                 440                 445             


Pro Pro Pro Gln Gln Pro Pro Thr Ala Pro Pro Ser Gly Leu Lys Lys 
    450                 455                 460                 


Tyr Glu Glu Pro Leu Gln Ser Met Ile Ser Gln Thr Gln Ser Leu Gly 
465                 470                 475                 480 


Gly Pro Pro Leu Glu His Glu Val Pro Gly His Pro Pro Gly Gly Asp 
                485                 490                 495     


Met Gly Gln Gln Met Asn Met Met Ile Gln Arg Leu Gly Gln Asp Ser 
            500                 505                 510         


Leu Thr Pro Glu Gln Val Ala Trp Arg Lys Leu Gln Glu Glu Tyr Tyr 
        515                 520                 525             


Glu Glu Lys Arg Arg Lys Glu Glu Gln Ile Gly Leu His Gly Ser Arg 
    530                 535                 540                 


Pro Leu Gln Asp Met Met Gly Met Gly Gly Met Met Val Arg Gly Pro 
545                 550                 555                 560 


Pro Pro Pro Tyr His Ser Lys Pro Gly Asp Gln Trp Pro Pro Gly Met 
                565                 570                 575     


Gly Ala Gln Leu Arg Gly Pro Met Asp Val Gln Asp Pro Met Gln Leu 
            580                 585                 590         


Arg Gly Gly Pro Pro Phe Pro Gly Pro Arg Phe Pro Gly Asn Gln Ile 
        595                 600                 605             


Gln Arg Val Pro Gly Phe Gly Gly Met Gln Ser Met Pro Met Glu Val 
    610                 615                 620                 


Pro Met Asn Ala Met Gln Arg Pro Val Arg Pro Gly Met Gly Trp Thr 
625                 630                 635                 640 


Glu Asp Leu Pro Pro Met Gly Gly Pro Ser Asn Phe Ala Gln Asn Thr 
                645                 650                 655     


Met Pro Tyr Pro Gly Gly Gln Gly Glu Ala Glu Arg Phe Met Thr Pro 
            660                 665                 670         


Arg Val Arg Glu Glu Leu Leu Arg His Gln Leu Leu Glu Lys Arg Ser 
        675                 680                 685             


Met Gly Met Gln Arg Pro Leu Gly Met Ala Gly Ser Gly Met Gly Gln 
    690                 695                 700                 


Ser Met Glu Met Glu Arg Met Met Gln Ala His Arg Gln Met Asp Pro 
705                 710                 715                 720 


Ala Met Phe Pro Gly Gln Met Ala Gly Gly Glu Gly Leu Ala Gly Thr 
                725                 730                 735     


Pro Met Gly Met Glu Phe Gly Gly Gly Arg Gly Leu Leu Ser Pro Pro 
            740                 745                 750         


Met Gly Gln Ser Gly Leu Arg Glu Val Asp Pro Pro Met Gly Pro Gly 
        755                 760                 765             


Asn Leu Asn Met Asn Met Asn Val Asn Met Asn Met Asn Met Asn Leu 
    770                 775                 780                 


Asn Val Gln Met Thr Pro Gln Gln Gln Met Leu Met Ser Gln Lys Met 
785                 790                 795                 800 


Arg Gly Pro Gly Asp Leu Met Gly Pro Gln Gly Leu Ser Pro Glu Glu 
                805                 810                 815     


Met Ala Arg Val Arg Ala Gln Asn Ser Ser Gly Val Met Gly Gly Pro 
            820                 825                 830         


Gln Lys Met Leu Met Pro Ser Gln Phe Pro Asn Gln Gly Gln Gln Gly 
        835                 840                 845             


Phe Ser Gly Gly Gln Gly Pro Tyr Gln Ala Met Ser Gln Asp Met Gly 
    850                 855                 860                 


Asn Thr Gln Asp Met Phe Ser Pro Asp Gln Ser Ser Met Pro Met Ser 
865                 870                 875                 880 


Asn Val Gly Thr Thr Arg Leu Ser His Met Pro Leu Pro Pro Ala Ser 
                885                 890                 895     


Asn Pro Pro Gly Thr Val His Ser Ala Pro Asn Arg Gly Leu Gly Arg 
            900                 905                 910         


Arg Pro Ser Asp Leu Thr Ile Ser Ile Asn Gln Met Gly Ser Pro Gly 
        915                 920                 925             


Met Gly His Leu Lys Ser Pro Thr Leu Ser Gln Val His Ser Pro Leu 
    930                 935                 940                 


Val Thr Ser Pro Ser Ala Asn Leu Lys Ser Pro Gln Thr Pro Ser Gln 
945                 950                 955                 960 


Met Val Pro Leu Pro Ser Ala Asn Pro Pro Gly Pro Leu Lys Ser Pro 
                965                 970                 975     


Gln Val Leu Gly Ser Ser Leu Ser Val Arg Ser Pro Thr Gly Ser Pro 
            980                 985                 990         


Ser Arg Leu Lys Ser Pro Ser Met  Ala Val Pro Ser Pro  Gly Trp Val 
        995                 1000                 1005             


Ala Ser  Pro Lys Thr Ala Met  Pro Ser Pro Gly Val  Ser Gln Asn 
    1010                 1015                 1020             


Lys Gln  Pro Pro Leu Asn Met  Asn Ser Ser Thr Thr  Leu Ser Asn 
    1025                 1030                 1035             


Met Glu  Gln Gly Thr Leu Pro  Pro Ser Gly Pro Arg  Ser Ser Ser 
    1040                 1045                 1050             


Ser Ala  Pro Pro Ala Asn Pro  Pro Ser Gly Leu Met  Asn Pro Ser 
    1055                 1060                 1065             


Leu Pro  Phe Thr Ser Ser Pro  Asp Pro Thr Pro Ser  Gln Asn Pro 
    1070                 1075                 1080             


Leu Ser  Leu Met Met Thr Gln  Met Ser Lys Tyr Ala  Met Pro Ser 
    1085                 1090                 1095             


Ser Thr  Pro Leu Tyr His Asn  Ala Ile Lys Thr Ile  Ala Thr Ser 
    1100                 1105                 1110             


Asp Asp  Glu Leu Leu Pro Asp  Arg Pro Leu Leu Pro  Pro Pro Pro 
    1115                 1120                 1125             


Pro Pro  Gln Gly Ser Gly Pro  Gly Ile Ser Asn Ser  Gln Pro Ser 
    1130                 1135                 1140             


Gln Met  His Leu Asn Ser Ala  Ala Ala Gln Ser Pro  Met Gly Met 
    1145                 1150                 1155             


Asn Leu  Pro Gly Gln Gln Pro  Leu Ser His Glu Pro  Pro Pro Ala 
    1160                 1165                 1170             


Met Leu  Pro Ser Pro Thr Pro  Leu Gly Ser Asn Ile  Pro Leu His 
    1175                 1180                 1185             


Pro Asn  Ala Gln Gly Thr Gly  Gly Pro Pro Gln Asn  Ser Met Met 
    1190                 1195                 1200             


Met Ala  Pro Gly Gly Pro Asp  Ser Leu Asn Ala Pro  Cys Gly Pro 
    1205                 1210                 1215             


Val Pro  Ser Ser Ser Gln Met  Met Pro Phe Pro Pro  Arg Leu Gln 
    1220                 1225                 1230             


Gln Pro  His Gly Ala Met Ala  Pro Thr Gly Gly Gly  Gly Gly Gly 
    1235                 1240                 1245             


Pro Gly  Leu Gln Gln His Tyr  Pro Ser Gly Met Ala  Leu Pro Pro 
    1250                 1255                 1260             


Glu Asp  Leu Pro Asn Gln Pro  Pro Gly Pro Met Pro  Pro Gln Gln 
    1265                 1270                 1275             


His Leu  Met Gly Lys Ala Met  Ala Gly Arg Met Gly  Asp Ala Tyr 
    1280                 1285                 1290             


Pro Pro  Gly Val Leu Pro Gly  Val Ala Ser Val Leu  Asn Asp Pro 
    1295                 1300                 1305             


Glu Leu  Ser Glu Val Ile Arg  Pro Thr Pro Thr Gly  Ile Pro Glu 
    1310                 1315                 1320             


Phe Asp  Leu Ser Arg Ile Ile  Pro Ser Glu Lys Pro  Ser Ser Thr 
    1325                 1330                 1335             


Leu Gln  Tyr Phe Pro Lys Ser  Glu Asn Gln Pro Pro  Lys Ala Gln 
    1340                 1345                 1350             


Pro Pro  Asn Leu His Leu Met  Asn Leu Gln Asn Met  Met Ala Glu 
    1355                 1360                 1365             


Gln Thr  Pro Ser Arg Pro Pro  Asn Leu Pro Gly Gln  Gln Gly Val 
    1370                 1375                 1380             


Gln Arg  Gly Leu Asn Met Ser  Met Cys His Pro Gly  Gln Met Ser 
    1385                 1390                 1395             


Leu Leu  Gly Arg Thr Gly Val  Pro Pro Gln Gln Gly  Met Val Pro 
    1400                 1405                 1410             


His Gly  Leu His Gln Gly Val  Met Ser Pro Pro Gln  Gly Leu Met 
    1415                 1420                 1425             


Thr Gln  Gln Asn Phe Met Leu  Met Lys Gln Arg Gly  Val Gly Gly 
    1430                 1435                 1440             


Glu Val  Tyr Ser Gln Pro Pro  His Met Leu Ser Pro  Gln Gly Ser 
    1445                 1450                 1455             


Leu Met  Gly Pro Pro Pro Gln  Gln Asn Leu Met Val  Ser His Pro 
    1460                 1465                 1470             


Leu Arg  Gln Arg Ser Val Ser  Leu Asp Ser Gln Met  Gly Tyr Leu 
    1475                 1480                 1485             


Pro Ala  Pro Gly Gly Met Ala  Asn Leu Pro Phe 
    1490                 1495                 

<210>  2888
<211>  130
<212>  DNA
<213>  Homo sapiens

<400>  2888
gccccagcag aacctcatgg tgtcccaccc ccttcggcag cgcagtgtgt ccctggacag     60

ccagatgggc tacctcccgg caccaggtgc cagccggagc tgtaaataga gcgctgcgct    120

tttgtgctgg                                                           130


<210>  2889
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  2889


Met Val Ser His Pro Leu Arg Gln Arg Ser Val Ser Leu Asp Ser Gln 
1               5                   10                  15      


Met Gly Tyr Leu Pro Ala Pro Gly Ala Ser Arg Ser Cys Lys 
            20                  25                  30  

<210>  2890
<211>  1515
<212>  DNA
<213>  Homo sapiens

<400>  2890
gccagagagc cccgatgctt attcaggctg gggagtggag ccgagtggag gggcaagcga     60

ggctccggca gcgcagggga gcccggggag gcggcggcgc gcggcggagc cagtggctgg    120

acatgccccg gacccggggc cgctgcacca ccgccgccgc ccggagccag ccggccggac    180

gcccgcacgc ctgggtcccc cggcgccgcg ccgcccgggg gctgtgaccc ggaccctcgg    240

agtccgacca acaataagcg cccagacagc ccctccccac ccagcgcccg gcattcccgc    300

gggctttggg gaaaggaaag gagaggcgag gaaggaagga aggaagcaag caagcaagca    360

agggaaggag gagcaggagc aggagccgga gccctgaggt tcggggccga gaccccggcc    420

ccgcgccccg gccccggcgg gtgtgcgcgc tctcccgcca ctgcccggcg cccgcgacag    480

gggacagggg ggccccctca aaactccatg atgatggccc cagggggccc cgactccctg    540

aatgccccct gtggcccagt gcccagctcc tcccagatga tgcccttccc ccctcggctg    600

cagcagcccc atggtgccat ggcccccact gggggtgggg gcggggggcc tggcctgcag    660

cagcactacc cgtcaggcat ggccctgcct cccgaggacc tgcccaacca gccgccaggc    720

cccatgcctc cccagcagca cctgatgggc aaagccatgg ctgggcgcat gggcgacgca    780

tacccaccgg gtgtgctccc tggggtggca tcagtgctga acgaccccga gctgagcgag    840

gtgatccggc ccaccccaac ggggatcccc gagttcgact tgtcgaggat catcccctct    900

gagaagccaa gcagcaccct ccagtacttc cccaagagcg agaaccagcc ccccaaggct    960

cagcccccta atctgcatct catgaacctg cagaacatga tggcggagca gactccctct   1020

cggcctccca acctcccagg ccagcagggc gtccagcggg ggctcaacat gtccatgtgc   1080

caccctggac agatgtcctt gctgggcagg acaggcgtgc ccccacagca ggggatggtg   1140

ccccatggcc tgcaccaggg ggtcatgtcc cctccacaag gcctcatgac ccagcagaat   1200

ttcatgctga tgaagcagcg gggcgtgggg ggcgaggtct acagccagcc gccccacatg   1260

ctctccccgc agggctccct catgggcccc ccgccccagc agaacctcat ggtgtcccac   1320

ccccttcggc agcgcagtgt gtccctggac agccagatgg gctacctccc ggcaccaggc   1380

ggcatggcca acctgccctt ctagaagtcg ctgccagggc tggagccggg gcaatgttgc   1440

aaatacgata accttaacaa agttcttccc ctcaatgttg ggatggcctg ggtcgcgggg   1500

tggggtggag ggggt                                                    1515


<210>  2891
<211>  298
<212>  PRT
<213>  Homo sapiens

<400>  2891


Met Met Met Ala Pro Gly Gly Pro Asp Ser Leu Asn Ala Pro Cys Gly 
1               5                   10                  15      


Pro Val Pro Ser Ser Ser Gln Met Met Pro Phe Pro Pro Arg Leu Gln 
            20                  25                  30          


Gln Pro His Gly Ala Met Ala Pro Thr Gly Gly Gly Gly Gly Gly Pro 
        35                  40                  45              


Gly Leu Gln Gln His Tyr Pro Ser Gly Met Ala Leu Pro Pro Glu Asp 
    50                  55                  60                  


Leu Pro Asn Gln Pro Pro Gly Pro Met Pro Pro Gln Gln His Leu Met 
65                  70                  75                  80  


Gly Lys Ala Met Ala Gly Arg Met Gly Asp Ala Tyr Pro Pro Gly Val 
                85                  90                  95      


Leu Pro Gly Val Ala Ser Val Leu Asn Asp Pro Glu Leu Ser Glu Val 
            100                 105                 110         


Ile Arg Pro Thr Pro Thr Gly Ile Pro Glu Phe Asp Leu Ser Arg Ile 
        115                 120                 125             


Ile Pro Ser Glu Lys Pro Ser Ser Thr Leu Gln Tyr Phe Pro Lys Ser 
    130                 135                 140                 


Glu Asn Gln Pro Pro Lys Ala Gln Pro Pro Asn Leu His Leu Met Asn 
145                 150                 155                 160 


Leu Gln Asn Met Met Ala Glu Gln Thr Pro Ser Arg Pro Pro Asn Leu 
                165                 170                 175     


Pro Gly Gln Gln Gly Val Gln Arg Gly Leu Asn Met Ser Met Cys His 
            180                 185                 190         


Pro Gly Gln Met Ser Leu Leu Gly Arg Thr Gly Val Pro Pro Gln Gln 
        195                 200                 205             


Gly Met Val Pro His Gly Leu His Gln Gly Val Met Ser Pro Pro Gln 
    210                 215                 220                 


Gly Leu Met Thr Gln Gln Asn Phe Met Leu Met Lys Gln Arg Gly Val 
225                 230                 235                 240 


Gly Gly Glu Val Tyr Ser Gln Pro Pro His Met Leu Ser Pro Gln Gly 
                245                 250                 255     


Ser Leu Met Gly Pro Pro Pro Gln Gln Asn Leu Met Val Ser His Pro 
            260                 265                 270         


Leu Arg Gln Arg Ser Val Ser Leu Asp Ser Gln Met Gly Tyr Leu Pro 
        275                 280                 285             


Ala Pro Gly Gly Met Ala Asn Leu Pro Phe 
    290                 295             

<210>  2892
<211>  322
<212>  DNA
<213>  Homo sapiens

<400>  2892
ctcccgccta gcggcccccg gagcagctcc tcagcacctc ccgccaaccc tcccagcggc     60

ctcatgaacc ccagcctacc attcacttcc tccccagacc ccacaccttc ccagaacccc    120

ctgtcactga tgatgaccca gatgtccaag tacgccatgc ccagctccac cccgctctac    180

cacaatgcca tcaagaccat cgccacctca gacgacgagc tgctgcccga ccggcccctg    240

ctgccccccc cacccctctg ggctccaaca ttccactgca tcccaacgca caggggacag    300

gggggccccc tcaaaactcc at                                             322


<210>  2893
<211>  85
<212>  PRT
<213>  Homo sapiens

<400>  2893


Met Asn Pro Ser Leu Pro Phe Thr Ser Ser Pro Asp Pro Thr Pro Ser 
1               5                   10                  15      


Gln Asn Pro Leu Ser Leu Met Met Thr Gln Met Ser Lys Tyr Ala Met 
            20                  25                  30          


Pro Ser Ser Thr Pro Leu Tyr His Asn Ala Ile Lys Thr Ile Ala Thr 
        35                  40                  45              


Ser Asp Asp Glu Leu Leu Pro Asp Arg Pro Leu Leu Pro Pro Pro Pro 
    50                  55                  60                  


Leu Trp Ala Pro Thr Phe His Cys Ile Pro Thr His Arg Gly Gln Gly 
65                  70                  75                  80  


Gly Pro Leu Lys Thr 
                85  

<210>  2894
<211>  565
<212>  DNA
<213>  Homo sapiens

<400>  2894
cacagagaag gggtgagcct cacaagttgt caggcttcct gatttatttt gtggaaaata     60

aaattcacta aaaaaataca ataaagggga aaataaacag attaaagcca gaatgagcca    120

gctccttgca aaccagccat tctactcctg atggagaagg cagctgaggg aattagcgag    180

cttaatccct ccagccagca gctacaggcc gtcctggggc tggatagctc tgcttcaagg    240

agaagcctcc tgacctcaat ggaggatccc tgagctatag gactgacggg ggcttcatat    300

ttgcagctgg aatttacacg cgcctctgcc ctcttccacg gccaaggttc ccttcaaatg    360

gacatttgag catgctctga ttctcagcac tccctgggga aaagaaagaa gaaaccgggc    420

tggcagaatg gaggtgaggg aggaggtggc tgtcttcagt atgtactccc ctcctgagcc    480

tggccaagag ctcatgcact ctttcccctg ccttcttcct ctgtgtgccc actcttctgt    540

cactgttcct gctcagccct ccctt                                          565


<210>  2895
<211>  40
<212>  PRT
<213>  Homo sapiens

<400>  2895


Met Glu Lys Ala Ala Glu Gly Ile Ser Glu Leu Asn Pro Ser Ser Gln 
1               5                   10                  15      


Gln Leu Gln Ala Val Leu Gly Leu Asp Ser Ser Ala Ser Arg Arg Ser 
            20                  25                  30          


Leu Leu Thr Ser Met Glu Asp Pro 
        35                  40  

<210>  2896
<211>  569
<212>  DNA
<213>  Homo sapiens

<400>  2896
acagctgtgc ccatccctgc cccagtgaaa gctatggatt taatccccaa gcgtactcaa     60

tgaatcaaat gcaggtatgg attgtggatc ccagtaagcc cgtccatgta ctccagccgt    120

ccttgaaaat ggatatttgg ggcatgagga gcagattgag gtgaagaaat gcagagctag    180

gatggcggag ggaagaagag ggagactgag agcccagggg attcggaaat ccggaggact    240

gtgctggact ttctaacagg agagagccac tcaggaagac tggatgactg gggcatactt    300

cgatgatgga agaaatgatg gtgatgaaaa ccctcaagga aataattcac ctccagtaac    360

atcagagctg tcctttaggt tctgaagtta gcacaggccc ttatgagtgg aggggcagct    420

gttcattatc cttacctact ccgcttcacc ccaaggtggt cccctgtctc actggtgtca    480

atcaacagca aagatcctgt cctctaacta cctgcaaaaa cactacttaa ggtgtcgccc    540

cctcttcatg ggagtagaca tattctcct                                      569


<210>  2897
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  2897


Met Asn Gln Met Gln Val Trp Ile Val Asp Pro Ser Lys Pro Val His 
1               5                   10                  15      


Val Leu Gln Pro Ser Leu Lys Met Asp Ile Trp Gly Met Arg Ser Arg 
            20                  25                  30          


Leu Arg 
        

<210>  2898
<211>  3089
<212>  DNA
<213>  Homo sapiens

<400>  2898
aatttcatct ggcgcccccg ttcaatcagc ctgcattgtc gaggctttag gagaggcagt     60

taggaaagga gagatactga tctctcagcc ccagggcagc actaatggtg cctgtctaga    120

ctctgacagg tggagctgct gagctaacta cggacctggt gggggaagtt ttccttggct    180

ttcacgtggc tttggctggg gagccctgag aaggtggctg cctccttttt ctgaagcctg    240

gcttcccata cggcagtggc tgggggagag tgatggagag aaaggctaag ctaaggtcaa    300

agaaagtgga ggaaggctgg cttgtcccgc tggacttgac ggcggagctg ctgcaatctc    360

gcgggctggg cccttgcccc gggtggaccc gagtgcctgc ggggaggcgg gtgtggctcc    420

cccgggaggt gacagctggc ggggcccgta aggagctggt ctgctccggc tcccctctcg    480

tagccggcgc cctgggacca gcgcgtgagc acgtctcgga ggagtccgat gcgctgggca    540

gggccgggtg gtcacccccg cccagcttcc aggggtgact gtgcctctga cgtcagacgg    600

tttttgggtc attccctggc acggggactt tattttcata acagcatgaa gtgccgtgga    660

actggaatag gcgtgtcctc tccctcgacc ctccccctcc ttgtccctct gctcacccct    720

cgctcgttcc ctccctccgg cgagggccgc ctttataaca actgctcaga gtgcgagggc    780

gggatagctg tccaaggtct cccccagcac tgaggagctc gcctgctgcc ctcttgcgcg    840

cgggaagcag caccaagttc acggccaacg ccttggcact agggtccaga atggctacaa    900

cagtccctga tggttgccgc aatggcctga aatccaagta ctacagactt tgtgataagg    960

ctgaagcttg gggcatcgtc ctagaaacgg tggccacagc cggggttgtg acctcggtgg   1020

ccttcatgct cactctcccg atcctcgtct gcaaggtgca ggactccaac aggcgaaaaa   1080

tgctgcctac tcagtttctc ttcctcctgg gtgtgttggg catctttggc ctcaccttcg   1140

ccttcatcat cggactggac gggagcacag ggcccacacg cttcttcctc tttgggatcc   1200

tcttttccat ctgcttctcc tgcctgctgg ctcatgctgt cagtctgacc aagctcgtcc   1260

gggggaggaa gcccctttcc ctgttggtga ttctgggtct ggccgtgggc ttcagcctag   1320

tccaggatgt tatcgctatt gaatatattg tcctgaccat gaataggacc aacgtcaatg   1380

tcttttctga gctttccgct cctcgtcgca atgaagactt tgtcctcctg ctcacctacg   1440

tcctcttctt gatggcgctg accttcctca tgtcctcctt caccttctgt ggttccttca   1500

cgggctggaa gagacatggg gcccacatct acctcacgat gctcctctcc attgccatct   1560

gggtggcctg gatcaccctg ctcatgcttc ctgactttga ccgcaggtgg gatgacacca   1620

tcctcagctc cgccttggct gccaatggct gggtgttcct gttggcttat gttagtcccg   1680

agttttggct gctcacaaag caacgaaacc ccatggatta tcctgttgag gatgctttct   1740

gtaaacctca actcgtgaag aagagctatg gtgtggagaa cagagcctac tctcaagagg   1800

aaatcactca aggttttgaa gagacagggg acacgctcta tgccccctat tccacacatt   1860

ttcagctgca gaaccagcct ccccaaaagg aattctccat cccacgggcc cacgcttggc   1920

cgagccctta caaagactat gaagtaaaga aagagggcag ctaactctgt cctgaagagt   1980

gggacaaatg cagccgggcg gcagatctag cgggagctca aagggatgtg ggcgaaatct   2040

tgagtcttct gagaaaactg tacaagacac tacgggaaca gtttgcctcc ctcccagcct   2100

caaccacaat tcttccatgc tggggctgat gtgggctagt aagactccag ttcttagagg   2160

cgctgtagta tttttttttt tttgtctcat cctttggata cttcttttaa gtgggagtct   2220

caggcaactc aagtttagac ccttactctt tttgtttgtt ttttgaaaca ggatcttgct   2280

ctgtcaccca ggcttgagtg cagtggtgcg atcacagccc agtgcagcct cgaccacctg   2340

tgctcaagca atcctcccat ctccatctcc caaagtgctg ggatgacagg cgtgagccac   2400

agctcccagc ctaggccctt aatcttgctg ttattttcca tggactaaag gtctggtcat   2460

ctgagctcac gctggctcac acagctctag gggcctgctc ctctaactca cagtgggttt   2520

tgtgaggctc tgtggcccag agcagacctg catatctgag caaaaatagc aaaagcctct   2580

ctcagcccac tggcctgaat ctacactgga agccaacttg ctggcacccc cgctccccaa   2640

cccttcttgc ctgggtagga gaggctaaag atcaccctaa atttactcat ctctctagtg   2700

ctgcctcaca ttgggcctca gcagctcccc agcaccaatt cacaggtcac ccctctcttc   2760

ttgcactgtc cccaaacttg ctgtcaattc cgagatctaa tctcccccta cgctctgcca   2820

ggaattcttt cagacctcac tagcacaagc ccggttgctc cttgtcagga gaatttgtag   2880

atcattctca cttcaaattc ctggggctga tacttctctc atcttgcacc ccaacctctg   2940

taaatagatt taccgcattt acggctgcat tctgtaagtg ggcatggtct cctaatggag   3000

gagtgttcat tgtataataa gttattcacc tgagtatgca ataaagatgt ggtggccact   3060

ctttcatggt ggtggcagca gttaccagt                                     3089


<210>  2899
<211>  357
<212>  PRT
<213>  Homo sapiens

<400>  2899


Met Ala Thr Thr Val Pro Asp Gly Cys Arg Asn Gly Leu Lys Ser Lys 
1               5                   10                  15      


Tyr Tyr Arg Leu Cys Asp Lys Ala Glu Ala Trp Gly Ile Val Leu Glu 
            20                  25                  30          


Thr Val Ala Thr Ala Gly Val Val Thr Ser Val Ala Phe Met Leu Thr 
        35                  40                  45              


Leu Pro Ile Leu Val Cys Lys Val Gln Asp Ser Asn Arg Arg Lys Met 
    50                  55                  60                  


Leu Pro Thr Gln Phe Leu Phe Leu Leu Gly Val Leu Gly Ile Phe Gly 
65                  70                  75                  80  


Leu Thr Phe Ala Phe Ile Ile Gly Leu Asp Gly Ser Thr Gly Pro Thr 
                85                  90                  95      


Arg Phe Phe Leu Phe Gly Ile Leu Phe Ser Ile Cys Phe Ser Cys Leu 
            100                 105                 110         


Leu Ala His Ala Val Ser Leu Thr Lys Leu Val Arg Gly Arg Lys Pro 
        115                 120                 125             


Leu Ser Leu Leu Val Ile Leu Gly Leu Ala Val Gly Phe Ser Leu Val 
    130                 135                 140                 


Gln Asp Val Ile Ala Ile Glu Tyr Ile Val Leu Thr Met Asn Arg Thr 
145                 150                 155                 160 


Asn Val Asn Val Phe Ser Glu Leu Ser Ala Pro Arg Arg Asn Glu Asp 
                165                 170                 175     


Phe Val Leu Leu Leu Thr Tyr Val Leu Phe Leu Met Ala Leu Thr Phe 
            180                 185                 190         


Leu Met Ser Ser Phe Thr Phe Cys Gly Ser Phe Thr Gly Trp Lys Arg 
        195                 200                 205             


His Gly Ala His Ile Tyr Leu Thr Met Leu Leu Ser Ile Ala Ile Trp 
    210                 215                 220                 


Val Ala Trp Ile Thr Leu Leu Met Leu Pro Asp Phe Asp Arg Arg Trp 
225                 230                 235                 240 


Asp Asp Thr Ile Leu Ser Ser Ala Leu Ala Ala Asn Gly Trp Val Phe 
                245                 250                 255     


Leu Leu Ala Tyr Val Ser Pro Glu Phe Trp Leu Leu Thr Lys Gln Arg 
            260                 265                 270         


Asn Pro Met Asp Tyr Pro Val Glu Asp Ala Phe Cys Lys Pro Gln Leu 
        275                 280                 285             


Val Lys Lys Ser Tyr Gly Val Glu Asn Arg Ala Tyr Ser Gln Glu Glu 
    290                 295                 300                 


Ile Thr Gln Gly Phe Glu Glu Thr Gly Asp Thr Leu Tyr Ala Pro Tyr 
305                 310                 315                 320 


Ser Thr His Phe Gln Leu Gln Asn Gln Pro Pro Gln Lys Glu Phe Ser 
                325                 330                 335     


Ile Pro Arg Ala His Ala Trp Pro Ser Pro Tyr Lys Asp Tyr Glu Val 
            340                 345                 350         


Lys Lys Glu Gly Ser 
        355         

<210>  2900
<211>  4285
<212>  DNA
<213>  Homo sapiens

<400>  2900
aatttcatct ggcgcccccg ttcaatcagc ctgcattgtc gaggctttag gagaggcagt     60

taggaaagga gagatactga tctctcagcc ccagggcagc actaatggtg cctgtctaga    120

ctctgacagg tggagctgct gagctaacta cggacctggt gggggaagtt ttccttggct    180

ttcacgtggc tttggctggg gagccctgag aaggtggctg cctccttttt ctgaagcctg    240

gcttcccata cggcagtggc tgggggagag tgatggagag aaaggctaag ctaaggtcaa    300

agaaagtgga ggaaggctgg cttgtcccgc tggacttgac ggcggagctg ctgcaatctc    360

gcgggctggg cccttgcccc gggtggaccc gagtgcctgc ggggaggcgg gtgtggctcc    420

cccgggaggt gacagctggc ggggcccgta aggagctggt ctgctccggc tcccctctcg    480

tagccggcgc cctgggacca gcgcgtgagc acgtctcgga ggagtccgat gcgctgggca    540

gggccgggtg gtcacccccg cccagcttcc aggggtgact gtgcctctga cgtcagacgg    600

tttttgggtc attccctggc acggggactt tattttcata acagcatgaa gtgccgtgga    660

actggaatag gcgtgtcctc tccctcgacc ctccccctcc ttgtccctct gctcacccct    720

cgctcgttcc ctccctccgg cgagggccgc ctttataaca actgctcaga gtgcgagggc    780

gggatagctg tccaaggtct cccccagcac tgaggagctc gcctgctgcc ctcttgcgcg    840

cgggaagcag caccaagttc acggccaacg ccttggcact agggtccaga atggctacaa    900

cagtccctga tggttgccgc aatggcctga aatccaagta ctacagactt tgtgataagg    960

ctgaagcttg gggcatcgtc ctagaaacgg tggccacagc cggggttgtg acctcggtgg   1020

ccttcatgct cactctcccg atcctcgtct gcaaggtgca ggactccaac aggcgaaaaa   1080

tgctgcctac tcagtttctc ttcctcctgg gtgtgttggg catctttggc ctcaccttcg   1140

ccttcatcat cggactggac gggagcacag ggcccacacg cttcttcctc tttgggatcc   1200

tcttttccat ctgcttctcc tgcctgctgg ctcatgctgt cagtctgacc aagctcgtcc   1260

gggggaggaa gcccctttcc ctgttggtga ttctgggtct ggccgtgggc ttcagcctag   1320

tccaggatgt tatcgctatt gaatatattg tcctgaccat gaataggacc aacgtcaatg   1380

tcttttctga gctttccgct cctcgtcgca atgaagactt tgtcctcctg ctcacctacg   1440

tcctcttctt gatggcgctg accttcctca tgtcctcctt caccttctgt ggttccttca   1500

cgggctggaa gagacatggg gcccacatct acctcacgat gctcctctcc attgccatct   1560

gggtggcctg gatcaccctg ctcatgcttc ctgactttga ccgcaggtgg gatgacacca   1620

tcctcagctc cgccttggct gccaatggct gggtgttcct gttggcttat gttagtcccg   1680

agttttggct gctcacaaag caacgaaacc ccatggatta tcctgttgag gatgctttct   1740

gtaaacctca actcgtgaag aagagctatg gtgtggagaa cagagcctac tctcaagagg   1800

aaatcactca aggttttgaa gagacagggg acacgctcta tgccccctat tccacacatt   1860

ttcagctgca gaaccagcct ccccaaaagg aattctccat cccacgggcc cacgcttggc   1920

cgagccctta caaagactat gaagtaaaga aagagggcag ctaactctgt cctgaagagt   1980

gggacaaatg cagccgggcg gcagatctag cgggagctca aagggatgtg ggcgaaatct   2040

tgagtcttct gagaaaactg tacaagacac tacgggaaca gtttgcctcc ctcccagcct   2100

caaccacaat tcttccatgc tggggctgat gtgggctagt aagactccag ttcttagagg   2160

cgctgtagta tttttttttt tttgtctcat cctttggata cttcttttaa gtgggagtct   2220

caggcaactc aagtttagac ccttactctt tttgtttgtt ttttgaaaca ggatcttgct   2280

ctgtcaccca ggcttgagtg cagtggtgcg atcacagccc agtgcagcct cgaccacctg   2340

tgctcaagca atcctcccat ctccatctcc caaagtgctg ggatgacagg cgtgagccac   2400

agctcccagc ctaggccctt aatcttgctg ttattttcca tggactaaag gtctggtcat   2460

ctgagctcac gctggctcac acagctctag gggcctgctc ctctaactca cagtgggttt   2520

tgtgaggctc tgtggcccag agcagacctg catatctgag caaaaatagc aaaagcctct   2580

ctcagcccac tggcctgaat ctacactgga agccaacttg ctggcacccc cgctccccaa   2640

cccttcttgc ctgggtagga gaggctaaag atcaccctaa atttactcat ctctctagtg   2700

ctgcctcaca ttgggcctca gcagctcccc agcaccaatt cacaggtcac ccctctcttc   2760

ttgcactgtc cccaaacttg ctgtcaattc cgagatctaa tctcccccta cgctctgcca   2820

ggaattcttt cagacctcac tagcacaagc ccggttgctc cttgtcagga gaatttgtag   2880

atcattctca cttcaaattc ctggggctga tacttctctc atcttgcacc ccaacctctg   2940

taaatagatt taccgcattt acggctgcat tctgtaagtg ggcatggtct cctaatggag   3000

gagtgttcat tgtataataa gttattcacc tgagtatgca ataaagatgt ggtggccact   3060

ctttcatggt ggtggcagca gttaccagta atgagcatta gactctgggg gatagaacac   3120

gggctgccct gagagcttca tgttggagct gaagttcaag gttcacttcc tttgggtttg   3180

tacttgaccc ttcttcatgt gtctctcccg ttccctctaa aacaagtgtg tttcccctca   3240

tttttgaggc tgtcaatggt gtgagagcca ggatcatcac ggggcctgag gttttactcc   3300

agaaaagcag aggagtggca accttggctt ggggtttggc agcccaggaa aggcagggag   3360

gagagctcaa agccggtttc atgtttcacc caaggtctaa ttgtgggaga ggacaaatcc   3420

agatcccctg tttgacagaa ttagttcaca aatgtctctt ggcaaaaaca tgtgacacct   3480

aaccatgata attgacttaa tccaagaaag agctctgtag ggcagagcaa taggaaatct   3540

ctctttcgtt atggaaaaaa aataatccct ctacatagaa actgagtgac atgtaaaaat   3600

gtgtagctaa gtcagggagt tacttcctaa gagcctgacg ctctgctttt catcaaaagg   3660

aaaaaccagc gtgaggcaga ggcgagggag gtggaggtga gtggatgatg tgctgagtta   3720

gggatgttta tatgccgcaa aggtttggtt ggtaggcttc gcgctaagat tagcctggct   3780

ttgtactgaa aagggggaag gacacatagt gacacagatc cttctggtct ttcccaggag   3840

gtgtgaccta atgaggtttg ttgtgagaat aaagcaatgt ggtttcacat atattatcta   3900

tcataggcta gggactcaag aaatgcatat tcccccccca ctttctttct ctctttcctt   3960

ccttccttcc tttcttcttt ctttctttct ttctttcttt ctttctttct ttctttcttt   4020

ctctctctct ctctctctct ctttctttct ttctttttga gatagagtct cactctgtca   4080

tccaggctgg agtgcagtgg catgatctca gctcactgca gcctccgcat cctgggttca   4140

agcgattttc gtgcctcggc cttctgagta gctgggatta caggcgtgcg tgcgccacca   4200

cgcctggcta atttttgtat ttttagtaca gacgaggttt caccatgttg accaggctgg   4260

tcttgaactc ctgatcttaa gtgat                                         4285


<210>  2901
<211>  357
<212>  PRT
<213>  Homo sapiens

<400>  2901


Met Ala Thr Thr Val Pro Asp Gly Cys Arg Asn Gly Leu Lys Ser Lys 
1               5                   10                  15      


Tyr Tyr Arg Leu Cys Asp Lys Ala Glu Ala Trp Gly Ile Val Leu Glu 
            20                  25                  30          


Thr Val Ala Thr Ala Gly Val Val Thr Ser Val Ala Phe Met Leu Thr 
        35                  40                  45              


Leu Pro Ile Leu Val Cys Lys Val Gln Asp Ser Asn Arg Arg Lys Met 
    50                  55                  60                  


Leu Pro Thr Gln Phe Leu Phe Leu Leu Gly Val Leu Gly Ile Phe Gly 
65                  70                  75                  80  


Leu Thr Phe Ala Phe Ile Ile Gly Leu Asp Gly Ser Thr Gly Pro Thr 
                85                  90                  95      


Arg Phe Phe Leu Phe Gly Ile Leu Phe Ser Ile Cys Phe Ser Cys Leu 
            100                 105                 110         


Leu Ala His Ala Val Ser Leu Thr Lys Leu Val Arg Gly Arg Lys Pro 
        115                 120                 125             


Leu Ser Leu Leu Val Ile Leu Gly Leu Ala Val Gly Phe Ser Leu Val 
    130                 135                 140                 


Gln Asp Val Ile Ala Ile Glu Tyr Ile Val Leu Thr Met Asn Arg Thr 
145                 150                 155                 160 


Asn Val Asn Val Phe Ser Glu Leu Ser Ala Pro Arg Arg Asn Glu Asp 
                165                 170                 175     


Phe Val Leu Leu Leu Thr Tyr Val Leu Phe Leu Met Ala Leu Thr Phe 
            180                 185                 190         


Leu Met Ser Ser Phe Thr Phe Cys Gly Ser Phe Thr Gly Trp Lys Arg 
        195                 200                 205             


His Gly Ala His Ile Tyr Leu Thr Met Leu Leu Ser Ile Ala Ile Trp 
    210                 215                 220                 


Val Ala Trp Ile Thr Leu Leu Met Leu Pro Asp Phe Asp Arg Arg Trp 
225                 230                 235                 240 


Asp Asp Thr Ile Leu Ser Ser Ala Leu Ala Ala Asn Gly Trp Val Phe 
                245                 250                 255     


Leu Leu Ala Tyr Val Ser Pro Glu Phe Trp Leu Leu Thr Lys Gln Arg 
            260                 265                 270         


Asn Pro Met Asp Tyr Pro Val Glu Asp Ala Phe Cys Lys Pro Gln Leu 
        275                 280                 285             


Val Lys Lys Ser Tyr Gly Val Glu Asn Arg Ala Tyr Ser Gln Glu Glu 
    290                 295                 300                 


Ile Thr Gln Gly Phe Glu Glu Thr Gly Asp Thr Leu Tyr Ala Pro Tyr 
305                 310                 315                 320 


Ser Thr His Phe Gln Leu Gln Asn Gln Pro Pro Gln Lys Glu Phe Ser 
                325                 330                 335     


Ile Pro Arg Ala His Ala Trp Pro Ser Pro Tyr Lys Asp Tyr Glu Val 
            340                 345                 350         


Lys Lys Glu Gly Ser 
        355         

<210>  2902
<211>  2339
<212>  DNA
<213>  Homo sapiens

<400>  2902
gcttcccata cggcagtggc tgggggagag tgatggagag aaaggctaag ctaaggtcaa     60

agaaagtgga ggaaggctgg cttgtcccgc tggacttgac ggcggagctg ctgcaatctc    120

gcgggctggg cccttgcccc gggtggaccc gagtgcctgc ggggaggcgg gtgtggctcc    180

cccgggaggt gacagctggc ggggcccgta aggagctggt ctgctccggc tcccctctcg    240

tagccggcgc cctgggacca gcgcgtgagc acgtctcgga ggagtccgat gcgctgggca    300

gggccgggtg gtcacccccg cccagcttcc aggggtgact gtgcctctga cgtcagacgg    360

tttttgggtc attccctggc acggggactt tattttcata acagcatgaa gtgccgtgga    420

actggaatag gcgtgtcctc tccctcgacc ctccccctcc ttgtccctct gctcacccct    480

cgctcgttcc ctccctccgg cgagggccgc ctttataaca actgctcaga gtgcgagggc    540

gggatagctg tccaaggtct cccccagcac tgaggagctc gcctgctgcc ctcttgcgcg    600

cgggaagcag caccaagttc acggccaacg ccttggcact agggtccaga atggctacaa    660

cagtccctga tggttgccgc aatggcctga aatccaagta ctacagactt tgtgataagg    720

ctgaagcttg gggcatcgtc ctagaaacgg tggccacagc cggggttgtg acctcggtgg    780

ccttcatgct cactctcccg atcctcgtct gcaaggtgca ggactccaac aggcgaaaaa    840

tgctgcctac tcagtttctc ttcctcctgg gtgtgttggg catctttggc ctcaccttcg    900

ccttcatcat cggactggac gggagcacag ggcccacacg cttcttcctc tttgggatcc    960

tcttttccat ctgcttctcc tgcctgctgg ctcatgctgt cagtctgacc aagctcgtcc   1020

gggggaggaa gcccctttcc ctgttggtga ttctgggtct ggccgtgggc ttcagcctag   1080

tccaggatgt tatcgctatt gaatatattg tcctgaccat gaataggacc aacgtcaatg   1140

tcttttctga gctttccgct cctcgtcgca atgaagactt tgtcctcctg ctcacctacg   1200

tcctcttctt gatggcgctg accttcctca tgtcctcctt caccttctgt ggttccttca   1260

cgggctggaa gagacatggg gcccacatct acctcacgat gctcctctcc attgccatct   1320

gggtggcctg gatcaccctg ctcatgcttc ctgactttga ccgcaggtgg gatgacacca   1380

tcctcagctc cgccttggct gccaatggct gggtgttcct gttggcttat gttagtcccg   1440

agttttggct gctcacaaag caacgaaacc ccatggatta tcctgttgag gatgctttct   1500

gtaaacctca actcgtgaag aagagctatg gtgtggagaa cagagcctac tctcaagagg   1560

aaatcactca aggtacagat gcagcctggc taggcagaga atcccttgta gaaaggtggg   1620

ggagaatcat aggatattat aactgtaagg aacatgcaag attttccaga ttataccctt   1680

gatagaatag ataagttcct taaggctcag atcttgctta aagtcgtcca gcctgttaga   1740

gacaagtaga acacgaagct ggcctctgga gtctttattg agtactttgt acaattggtg   1800

tagactggga gagccctcct cacttcccct ttcttgtgct gtaatttcct gtggggcaga   1860

acacctcaga ggtttctgtg catcaaaata agatgcagca aagacatgga aaaaggataa   1920

cgagacaaat tcccagcaat aagtagatga ggttgtgttt tttataaaag ataacgaggc   1980

attccttcca gaaatgtgga gcctttgtag atttcagtgc ataaaaccaa gccatgattt   2040

cctgcagtga tcacagagca gagaagggag aaagcccttt tatcacaaac cagcaggaag   2100

tctctgtaaa attggtaagg attctggttt agtgtgaaga accacatttt ttgtgtatgt   2160

ttctgggccc atgggaagga acagatcata tttgacatac aagaatcaaa tgattcaggc   2220

caggcatggt ggctcactcc tgtaatccta gccctctggg aggctgaggt gggaggattg   2280

cttgagccca gaagtttgag accagcttgg gcaaaatagc aagacttcat ctctattta    2339


<210>  2903
<211>  343
<212>  PRT
<213>  Homo sapiens

<400>  2903


Met Ala Thr Thr Val Pro Asp Gly Cys Arg Asn Gly Leu Lys Ser Lys 
1               5                   10                  15      


Tyr Tyr Arg Leu Cys Asp Lys Ala Glu Ala Trp Gly Ile Val Leu Glu 
            20                  25                  30          


Thr Val Ala Thr Ala Gly Val Val Thr Ser Val Ala Phe Met Leu Thr 
        35                  40                  45              


Leu Pro Ile Leu Val Cys Lys Val Gln Asp Ser Asn Arg Arg Lys Met 
    50                  55                  60                  


Leu Pro Thr Gln Phe Leu Phe Leu Leu Gly Val Leu Gly Ile Phe Gly 
65                  70                  75                  80  


Leu Thr Phe Ala Phe Ile Ile Gly Leu Asp Gly Ser Thr Gly Pro Thr 
                85                  90                  95      


Arg Phe Phe Leu Phe Gly Ile Leu Phe Ser Ile Cys Phe Ser Cys Leu 
            100                 105                 110         


Leu Ala His Ala Val Ser Leu Thr Lys Leu Val Arg Gly Arg Lys Pro 
        115                 120                 125             


Leu Ser Leu Leu Val Ile Leu Gly Leu Ala Val Gly Phe Ser Leu Val 
    130                 135                 140                 


Gln Asp Val Ile Ala Ile Glu Tyr Ile Val Leu Thr Met Asn Arg Thr 
145                 150                 155                 160 


Asn Val Asn Val Phe Ser Glu Leu Ser Ala Pro Arg Arg Asn Glu Asp 
                165                 170                 175     


Phe Val Leu Leu Leu Thr Tyr Val Leu Phe Leu Met Ala Leu Thr Phe 
            180                 185                 190         


Leu Met Ser Ser Phe Thr Phe Cys Gly Ser Phe Thr Gly Trp Lys Arg 
        195                 200                 205             


His Gly Ala His Ile Tyr Leu Thr Met Leu Leu Ser Ile Ala Ile Trp 
    210                 215                 220                 


Val Ala Trp Ile Thr Leu Leu Met Leu Pro Asp Phe Asp Arg Arg Trp 
225                 230                 235                 240 


Asp Asp Thr Ile Leu Ser Ser Ala Leu Ala Ala Asn Gly Trp Val Phe 
                245                 250                 255     


Leu Leu Ala Tyr Val Ser Pro Glu Phe Trp Leu Leu Thr Lys Gln Arg 
            260                 265                 270         


Asn Pro Met Asp Tyr Pro Val Glu Asp Ala Phe Cys Lys Pro Gln Leu 
        275                 280                 285             


Val Lys Lys Ser Tyr Gly Val Glu Asn Arg Ala Tyr Ser Gln Glu Glu 
    290                 295                 300                 


Ile Thr Gln Gly Thr Asp Ala Ala Trp Leu Gly Arg Glu Ser Leu Val 
305                 310                 315                 320 


Glu Arg Trp Gly Arg Ile Ile Gly Tyr Tyr Asn Cys Lys Glu His Ala 
                325                 330                 335     


Arg Phe Ser Arg Leu Tyr Pro 
            340             

<210>  2904
<211>  1920
<212>  DNA
<213>  Homo sapiens

<400>  2904
gcttcccata cggcagtggc tgggggagag tgatggagag aaaggctaag ctaaggtcaa     60

agaaagtgga ggaaggctgg cttgtcccgc tggacttgac ggcggagctg ctgcaatctc    120

gcgggctggg cccttgcccc gggtggaccc gagtgcctgc ggggaggcgg gtgtggctcc    180

cccgggaggt gacagctggc ggggcccgta aggagctggt ctgctccggc tcccctctcg    240

tagccggcgc cctgggacca gcgcgtgagc acgtctcgga ggagtccgat gcgctgggca    300

gggccgggtg gtcacccccg cccagcttcc aggggtgact gtgcctctga cgtcagacgg    360

tttttgggtc attccctggc acggggactt tattttcata acagcatgaa gtgccgtgga    420

actggaatag gcgtgtcctc tccctcgacc ctccccctcc ttgtccctct gctcacccct    480

cgctcgttcc ctccctccgg cgagggccgc ctttataaca actgctcaga gtgcgagggc    540

gggatagctg tccaaggtct cccccagcac tgaggagctc gcctgctgcc ctcttgcgcg    600

cgggaagcag caccaagttc acggccaacg ccttggcact agggttttga agagacaggg    660

gacacgctct atgcccccta ttccacacat tttcagctgc agaaccagcc tccccaaaag    720

gaattctcca tcccacgggc ccacgcttgg ccgagccctt acaaagacta tgaagtaaag    780

aaagagggca gctaactctg tcctgaagag tgggacaaat gcagccgggc ggcagatcta    840

gcgggagctc aaagggatgt gggcgaaatc ttgagtcttc tgagaaaact gtacaagaca    900

ctacgggaac agtttgcctc cctcccagcc tcaaccacaa ttcttccatg ctggggctga    960

tgtgggctag taagactcca gttcttagag gcgctgtagt attttttttt ttttgtctca   1020

tcctttggat acttctttta agtgggagtc tcaggcaact caagtttaga cccttactct   1080

ttttgtttgt tttttgaaac aggatcttgc tctgtcaccc aggcttgagt gcagtggtgc   1140

gatcacagcc cagtgcagcc tcgaccacct gtgctcaagc aatcctccca tctccatctc   1200

ccaaagtgct gggatgacag gcgtgagcca cagctcccag cctaggccct taatcttgct   1260

gttattttcc atggactaaa ggtctggtca tctgagctca cgctggctca cacagctcta   1320

ggggcctgct cctctaactc acagtgggtt ttgtgaggct ctgtggccca gagcagacct   1380

gcatatctga gcaaaaatag caaaagcctc tctcagccca ctggcctgaa tctacactgg   1440

aagccaactt gctggcaccc ccgctcccca acccttcttg cctgggtagg agaggctaaa   1500

gatcacccta aatttactca tctctctagt gctgcctcac attgggcctc agcagctccc   1560

cagcaccaat tcacaggtca cccctctctt cttgcactgt ccccaaactt gctgtcaatt   1620

ccgagatcta atctccccct acgctctgcc aggaattctt tcagacctca ctagcacaag   1680

cccggttgct ccttgtcagg agaatttgta gatcattctc acttcaaatt cctggggctg   1740

atacttctct catcttgcac cccaacctct gtaaatagat ttaccgcatt tacggctgca   1800

ttctgtaagt gggcatggtc tcctaatgga ggagtgttca ttgtataata agttattcac   1860

ctgagtatgc aataaagatg tggtggccac tctttcatgg tggtggcagc agttaccagt   1920


<210>  2905
<211>  35
<212>  PRT
<213>  Homo sapiens

<400>  2905


Met Pro Pro Ile Pro His Ile Phe Ser Cys Arg Thr Ser Leu Pro Lys 
1               5                   10                  15      


Arg Asn Ser Pro Ser His Gly Pro Thr Leu Gly Arg Ala Leu Thr Lys 
            20                  25                  30          


Thr Met Lys 
        35  

<210>  2906
<211>  3116
<212>  DNA
<213>  Homo sapiens

<400>  2906
gcttcccata cggcagtggc tgggggagag tgatggagag aaaggctaag ctaaggtcaa     60

agaaagtgga ggaaggctgg cttgtcccgc tggacttgac ggcggagctg ctgcaatctc    120

gcgggctggg cccttgcccc gggtggaccc gagtgcctgc ggggaggcgg gtgtggctcc    180

cccgggaggt gacagctggc ggggcccgta aggagctggt ctgctccggc tcccctctcg    240

tagccggcgc cctgggacca gcgcgtgagc acgtctcgga ggagtccgat gcgctgggca    300

gggccgggtg gtcacccccg cccagcttcc aggggtgact gtgcctctga cgtcagacgg    360

tttttgggtc attccctggc acggggactt tattttcata acagcatgaa gtgccgtgga    420

actggaatag gcgtgtcctc tccctcgacc ctccccctcc ttgtccctct gctcacccct    480

cgctcgttcc ctccctccgg cgagggccgc ctttataaca actgctcaga gtgcgagggc    540

gggatagctg tccaaggtct cccccagcac tgaggagctc gcctgctgcc ctcttgcgcg    600

cgggaagcag caccaagttc acggccaacg ccttggcact agggttttga agagacaggg    660

gacacgctct atgcccccta ttccacacat tttcagctgc agaaccagcc tccccaaaag    720

gaattctcca tcccacgggc ccacgcttgg ccgagccctt acaaagacta tgaagtaaag    780

aaagagggca gctaactctg tcctgaagag tgggacaaat gcagccgggc ggcagatcta    840

gcgggagctc aaagggatgt gggcgaaatc ttgagtcttc tgagaaaact gtacaagaca    900

ctacgggaac agtttgcctc cctcccagcc tcaaccacaa ttcttccatg ctggggctga    960

tgtgggctag taagactcca gttcttagag gcgctgtagt attttttttt ttttgtctca   1020

tcctttggat acttctttta agtgggagtc tcaggcaact caagtttaga cccttactct   1080

ttttgtttgt tttttgaaac aggatcttgc tctgtcaccc aggcttgagt gcagtggtgc   1140

gatcacagcc cagtgcagcc tcgaccacct gtgctcaagc aatcctccca tctccatctc   1200

ccaaagtgct gggatgacag gcgtgagcca cagctcccag cctaggccct taatcttgct   1260

gttattttcc atggactaaa ggtctggtca tctgagctca cgctggctca cacagctcta   1320

ggggcctgct cctctaactc acagtgggtt ttgtgaggct ctgtggccca gagcagacct   1380

gcatatctga gcaaaaatag caaaagcctc tctcagccca ctggcctgaa tctacactgg   1440

aagccaactt gctggcaccc ccgctcccca acccttcttg cctgggtagg agaggctaaa   1500

gatcacccta aatttactca tctctctagt gctgcctcac attgggcctc agcagctccc   1560

cagcaccaat tcacaggtca cccctctctt cttgcactgt ccccaaactt gctgtcaatt   1620

ccgagatcta atctccccct acgctctgcc aggaattctt tcagacctca ctagcacaag   1680

cccggttgct ccttgtcagg agaatttgta gatcattctc acttcaaatt cctggggctg   1740

atacttctct catcttgcac cccaacctct gtaaatagat ttaccgcatt tacggctgca   1800

ttctgtaagt gggcatggtc tcctaatgga ggagtgttca ttgtataata agttattcac   1860

ctgagtatgc aataaagatg tggtggccac tctttcatgg tggtggcagc agttaccagt   1920

aatgagcatt agactctggg ggatagaaca cgggctgccc tgagagcttc atgttggagc   1980

tgaagttcaa ggttcacttc ctttgggttt gtacttgacc cttcttcatg tgtctctccc   2040

gttccctcta aaacaagtgt gtttcccctc atttttgagg ctgtcaatgg tgtgagagcc   2100

aggatcatca cggggcctga ggttttactc cagaaaagca gaggagtggc aaccttggct   2160

tggggtttgg cagcccagga aaggcaggga ggagagctca aagccggttt catgtttcac   2220

ccaaggtcta attgtgggag aggacaaatc cagatcccct gtttgacaga attagttcac   2280

aaatgtctct tggcaaaaac atgtgacacc taaccatgat aattgactta atccaagaaa   2340

gagctctgta gggcagagca ataggaaatc tctctttcgt tatggaaaaa aaataatccc   2400

tctacataga aactgagtga catgtaaaaa tgtgtagcta agtcagggag ttacttccta   2460

agagcctgac gctctgcttt tcatcaaaag gaaaaaccag cgtgaggcag aggcgaggga   2520

ggtggaggtg agtggatgat gtgctgagtt agggatgttt atatgccgca aaggtttggt   2580

tggtaggctt cgcgctaaga ttagcctggc tttgtactga aaagggggaa ggacacatag   2640

tgacacagat ccttctggtc tttcccagga ggtgtgacct aatgaggttt gttgtgagaa   2700

taaagcaatg tggtttcaca tatattatct atcataggct agggactcaa gaaatgcata   2760

ttcccccccc actttctttc tctctttcct tccttccttc ctttcttctt tctttctttc   2820

tttctttctt tctttctttc tttctttctt tctctctctc tctctctctc tctttctttc   2880

tttctttttg agatagagtc tcactctgtc atccaggctg gagtgcagtg gcatgatctc   2940

agctcactgc agcctccgca tcctgggttc aagcgatttt cgtgcctcgg ccttctgagt   3000

agctgggatt acaggcgtgc gtgcgccacc acgcctggct aatttttgta tttttagtac   3060

agacgaggtt tcaccatgtt gaccaggctg gtcttgaact cctgatctta agtgat       3116


<210>  2907
<211>  35
<212>  PRT
<213>  Homo sapiens

<400>  2907


Met Pro Pro Ile Pro His Ile Phe Ser Cys Arg Thr Ser Leu Pro Lys 
1               5                   10                  15      


Arg Asn Ser Pro Ser His Gly Pro Thr Leu Gly Arg Ala Leu Thr Lys 
            20                  25                  30          


Thr Met Lys 
        35  

<210>  2908
<211>  2894
<212>  DNA
<213>  Homo sapiens

<400>  2908
ctttgtcgtt gttttattta aaatgttatt gtctctgatt agaaaataca gtcatgaggg     60

ctaaaaactg aaatgatgtg aaaaggcatc cattaagcag tgttgcccca ccaccctttc    120

catcagtctt gtctcatggg gatggggaaa atgaagacag aacgctttgc cttgctttgc    180

aatccctcct ttgaaggcct tctgtcccag gaagccaatg ttcatttgat gtggaagagg    240

gacctgtgtt taaccagaag ctgtcctccc tcatcccttt cccatggctt acacgcaatg    300

cttaaaatat acagtgaaat ttgagtagga ttctctactc aaagacttct ctgggaagtg    360

tccagaattg accacacagg tgctgacggt agaaagaaca cagacccaaa accctgatct    420

agttgcatta actccattag ccctgagttc ctctgtaaaa tgaagactgt ggaggcacca    480

actagaggat ttctgtgacc ttctcaaact ctaaaatttt tggcactgga ctgttccact    540

ttgaagggtc aagaaagaaa tctggaggtt gcagaaatca gggtcaggcg cacatacacg    600

cacgcacgca cacacacaca cacacacaca cacacacaca cacacacaga tccagcagca    660

tccttggaac atcctgaagt caagaaaggc acagcactgt ctgccccgat agaaggaatt    720

ccagaaaaca gccacgaggt tgggccacag aatttccaaa gagagcaatc tacaaactgg    780

gggttgattt cccagttcct ggatctcagc agtcaacaca cgagaaggat ttttttctga    840

agctgccacc tccaattctg aaataatccc atgtttcaga ctggggccgg gacggtggca    900

aacctgcaga ccctggcagc aagatgaggg caaggaaggg aaaggtcagc tgggcacagt    960

ccagttctca gcagtaatga cagaaatgaa ggaaggaagc tcagaatgag tgcacggggg   1020

aaatgggttt tgctgatgca tttccagggc cggccgtact ctttgttttg gcacactttt   1080

cctgacaaac agccagtgtt ctcaacacat aaatactagt ccacgttaac aacaatagca   1140

tatgagaccg ctctccgtaa agatgccaga ttggatgcaa atggactgga aataccttgg   1200

agggtttcac aaaaataaga caaagggcaa aggaactttg ccaaaggaga tggagagcaa   1260

ttctttaaag ttagtgggag ggaggaagca aagagctcat aaatacaagc ctcttaaaat   1320

gggacgcatt tgcctcgcgc ctactgggtg tctgcagctc agcttggtgc cccacacagg   1380

acaccgactt taagtggctg cctttgcaag gctgagaggc catgagggtt gatgcctgaa   1440

gtgtcagcgc catctagtgg aaacatgggg catggccgct ttggacggcc tcagcctaaa   1500

atgagaggca gagagacacg ctctatttcg catctcacaa tgcaagatga gagaaaggct   1560

gttgagtttt atttcatcat cgcccgttta ggtcaaagga gatgccactt tggctcccag   1620

tcatcaatca actggcaaca cccaaggacc aggctgggct acatttgcac attccatttc   1680

agcccaggta gagatggaga cacttataag aacggcttcg gaatgttctc cagtttgatt   1740

ctcagatgtc aaagcctgta ggccatgaga ggtccctact taaacagaac agctatcctt   1800

tggtaccctc tccaaagaaa agaaagagta aaaaaataat aacttttaaa aatagcttat   1860

ttatgtgcag aaggtgtgag acctgaagat gagttaacag ccgcagcagt gggaggaggg   1920

gtgacaggta ctgctcaaat gagcagcaac cttctgccac ctggcaagaa caggcgttca   1980

gtgcagggct ggcctgcccc tgcaggcttc agagaccact gcgtttctta gaagggaaac   2040

aacggggccg ggcgcggtgg ctcatgcctg taatcccagc actttcagag gccacggtat   2100

cccagcactt tcagaggcca aggtaggtgg atcacgaggt ttggagttcg agatctgcct   2160

ggcccatata gtgaaaccct gtctctacta aaaatacaaa aatcagccgg gcatggtgga   2220

ggaggaggag gaggagaagg aggagaagga agaaggagaa acaacagtcc agagatgatg   2280

ccatttccgg ggaaagaggt tgacttgagg aaggcagcca tgggaataaa agctcccaca   2340

gatccttttc actaaaaaga aagcaggccg ggtgcagtag ctcacgcctg taatcccagc   2400

acttgtggga ggccaaagca ggagaatctc gagttcaaga ccagcctggg caacagagca   2460

agacccccac ctctacaaaa aatatatttt gtgtgttttt caacaagtga ttcaaattgc   2520

tgctcagatt ttaaaactta ctgtaactat cagtgtaaag acccatgcct ggatcctgtt   2580

tcatttttat atcaacttgg taaaaatgct gttcttgaca ccctgtcctc tctatcctcc   2640

ctcaaaccac atgtgatctc tgaaaaaata aaattagcca agtgtggtag tgcacgtctg   2700

tggtcccagc tactcaggag actgaggcag gagaatcact cgagcacaga aagttgaggc   2760

tgcagtgagc tatgattgtg ccactgcact ccagcctggg ccatagagct agaccctgtc   2820

tcaaaaaaaa aaaaaaaaaa aaatgccgat ccagagtatt ttgtgatttt accttttact   2880

cctcctccct tgct                                                     2894


<210>  2909
<211>  62
<212>  PRT
<213>  Homo sapiens

<400>  2909


Met Gly Met Gly Lys Met Lys Thr Glu Arg Phe Ala Leu Leu Cys Asn 
1               5                   10                  15      


Pro Ser Phe Glu Gly Leu Leu Ser Gln Glu Ala Asn Val His Leu Met 
            20                  25                  30          


Trp Lys Arg Asp Leu Cys Leu Thr Arg Ser Cys Pro Pro Ser Ser Leu 
        35                  40                  45              


Ser His Gly Leu His Ala Met Leu Lys Ile Tyr Ser Glu Ile 
    50                  55                  60          

<210>  2910
<211>  821
<212>  DNA
<213>  Homo sapiens

<400>  2910
gtgtggacag cctacaccaa gggaagagtc aggggagaag gaacacaaga ctccggaagc     60

atgccagcgt ataaaaccac ttgggacaga actggagtca gagataccaa tttgggaagg    120

agaaggatct agtgacagaa acttgggagt gcccagtgga cactttgcct cattggttcg    180

tgcctcagct tccaatctgg acatggagca caataacagt gggcccactg ctctccgaat    240

tcctgcgcgc acttgaaggg agtgtctggt gcaggcatgc agggaggaag aatgactctg    300

agcttgacca ttcaacttcg aaactttaac atcaatggat cagcacacac tggtgtacgg    360

tctgctatgc atgcagccct gtgctaggca aaagaagtat cagaccagga actgacagcc    420

tcactgcaac aggaagagag gcttcacaca ataagcgttt cattcaacca ggctggacct    480

gtgcttattg agttgaacat cactgagcac aaaatgcaag ccagacacca taagagctgt    540

aaggatgata aagatgtctt tctaccctcg agagctctaa gtgtggtcag gagagaaaca    600

catgcaaaga ttatgctggc tggaaggaaa tgctggaatg aaggtggaag gtacatccag    660

aatgttctgg gggtgaggaa tagcgaatga tgggttctga cttagaacat gaagggaagg    720

tattaagaaa gaggtgatat taagcattta ttgagcatct ctactttttt tgtgtatgtg    780

accttgtttg gaaatacaat atctcttctt gatgctggca a                        821


<210>  2911
<211>  58
<212>  PRT
<213>  Homo sapiens

<400>  2911


Met Gln Ala Arg His His Lys Ser Cys Lys Asp Asp Lys Asp Val Phe 
1               5                   10                  15      


Leu Pro Ser Arg Ala Leu Ser Val Val Arg Arg Glu Thr His Ala Lys 
            20                  25                  30          


Ile Met Leu Ala Gly Arg Lys Cys Trp Asn Glu Gly Gly Arg Tyr Ile 
        35                  40                  45              


Gln Asn Val Leu Gly Val Arg Asn Ser Glu 
    50                  55              

<210>  2912
<211>  447
<212>  DNA
<213>  Homo sapiens

<400>  2912
tgtggacagc ctacaccaag ggaagagtca ggggagaagg aacacaagac tccggaagca     60

tgccagcgta taaaaccttc tctctctgtg acctgtaatt tgagggtgac aaaaaagaac    120

ttcccatgaa agaacaaaca aacatgacac cacctgggac cattgaagtt ggatttcccc    180

tggtaaggtc tgatgttata ccctttaatc atctttgttg ggttctgcca agcctcccca    240

aacttcccac acttctcatt agtggatcag tgggtatcct tgctagagac tgaccgattg    300

tgggtacaat ggcacggttg ttcttgctga ccacacatct gtttatacag taccatgatt    360

gtttcttgag caaacaaaag caaagacagt ggtaagttgt ttccctacta tcagctcatg    420

acctaccata acacttagga cgtttca                                        447


<210>  2913
<211>  55
<212>  PRT
<213>  Homo sapiens

<400>  2913


Met Lys Glu Gln Thr Asn Met Thr Pro Pro Gly Thr Ile Glu Val Gly 
1               5                   10                  15      


Phe Pro Leu Val Arg Ser Asp Val Ile Pro Phe Asn His Leu Cys Trp 
            20                  25                  30          


Val Leu Pro Ser Leu Pro Lys Leu Pro Thr Leu Leu Ile Ser Gly Ser 
        35                  40                  45              


Val Gly Ile Leu Ala Arg Asp 
    50                  55  

<210>  2914
<211>  480
<212>  DNA
<213>  Homo sapiens

<400>  2914
agcctacacc aagggaagag tcaggggaga aggaacacaa gactccggaa gcatgccagc     60

gtataaaacc acactttgcc tcattggttc gtgcctcagc ttccaatctg gacatggagc    120

acaataacag tgggcccact gctctccgaa ttcctgcgcg cacttgaagg gccagaaaag    180

caaattaaac tggaatgtta tggagaccac tatccctgcc tcctttcctt ttttaaaggt    240

ggcactaatt tctgtaattc tttccaagat gtggctttcc ttctgatata ccatcatggc    300

tggaagagaa gatatgggtg agcttagagg cttccacttg gccattttta ccataatagc    360

tctattcaac aggtcaagag agaaatctga ggacttttcc agtttttaat tataaccatc    420

ccaattatgc actcaggggc ctaaccatca ctggtaggtt tatgtagccc atgtgaagta    480


<210>  2915
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  2915


Met Ala Gly Arg Glu Asp Met Gly Glu Leu Arg Gly Phe His Leu Ala 
1               5                   10                  15      


Ile Phe Thr Ile Ile Ala Leu Phe Asn Arg Ser Arg Glu Lys Ser Glu 
            20                  25                  30          


Asp Phe Ser Ser Phe 
        35          

<210>  2916
<211>  729
<212>  DNA
<213>  Homo sapiens

<400>  2916
ctacaccaag ggaagagtca ggggagaagg aacacaagac tccggaagca tgccagcgta     60

taaaaccaca ctttgcctca ttggttcgtg cctcagcttc caatctggac atggagcaca    120

ataacagtgg gcccactgct ctccgaattc ctgcgcgcac ttgaagggag tgtctggtgc    180

aggcatgcag ggaggaagaa tgactctgag cttgaccatt caacttcgaa actttaacat    240

caatggatca gcacacactg gtgtacggtc tgctatgcat gcagccctgt gctaggcaaa    300

agaagtatca gaccaggaac tgacagcctc actgcaacag gaagagaggc ttcacacaat    360

aagcgtttca ttcaaccagg ctggacctgt gcttattgag ttgaacatca ctgagcacaa    420

aatgcaagcc agacaccata agagctgtaa ggatgataaa gatgtctttc taccctcgag    480

agctctaagt gtggtcagga gagaaacaca tgcaaagatt atgctggctg gaaggaaatg    540

ctggaatgaa ggtggaaggt acatccagaa tgttctgggg gtgaggaata gcgaatgatg    600

ggttctgact tagaacatga agggaaggta ttaagaaaga ggtgatatta agcatttatt    660

gagcatctct actttttttg tgtatgtgac cttgtttgga aatacaatat ctcttcttga    720

tgctggcaa                                                            729


<210>  2917
<211>  58
<212>  PRT
<213>  Homo sapiens

<400>  2917


Met Gln Ala Arg His His Lys Ser Cys Lys Asp Asp Lys Asp Val Phe 
1               5                   10                  15      


Leu Pro Ser Arg Ala Leu Ser Val Val Arg Arg Glu Thr His Ala Lys 
            20                  25                  30          


Ile Met Leu Ala Gly Arg Lys Cys Trp Asn Glu Gly Gly Arg Tyr Ile 
        35                  40                  45              


Gln Asn Val Leu Gly Val Arg Asn Ser Glu 
    50                  55              

<210>  2918
<211>  804
<212>  DNA
<213>  Homo sapiens

<400>  2918
caggggagaa ggaacacaag actccggaag catgccagcg tataaaacca actgcacaaa     60

caagccagaa actgaaccct acccggaatc ccctggtgta tgaagggagc ctagctctgg    120

ctgactctgc ttgtgttcac agacactttg cctcattggt tcgtgcctca gcttccaatc    180

tggacatgga gcacaataac agtgggccca ctgctctccg aattcctgcg cgcacttgaa    240

gggagtgtct ggtgcaggca tgcagggagg aagaatgact ctgagcttga ccattcaact    300

tcgaaacttt aacatcaatg gatcagcaca cactggtgta cggtctgcta tgcatgcagc    360

cctgtgctag gcaaaagaag tatcagacca ggaactgaca gcctcactgc aacaggaaga    420

gaggcttcac acaataagcg tttcattcaa ccaggctgga cctgtgctta ttgagttgaa    480

catcactgag cacaaaatgc aagccagaca ccataagagc tgtaaggatg ataaagatgt    540

ctttctaccc tcgagagctc taagtgtggt caggagagaa acacatgcaa agattatgct    600

ggctggaagg aaatgctgga atgaaggtgg aaggtacatc cagaatgttc tgggggtgag    660

gaatagcgaa tgatgggttc tgacttagaa catgaaggga aggtattaag aaagaggtga    720

tattaagcat ttattgagca tctctacttt ttttgtgtat gtgaccttgt ttggaaatac    780

aatatctctt cttgatgctg gcaa                                           804


<210>  2919
<211>  58
<212>  PRT
<213>  Homo sapiens

<400>  2919


Met Gln Ala Arg His His Lys Ser Cys Lys Asp Asp Lys Asp Val Phe 
1               5                   10                  15      


Leu Pro Ser Arg Ala Leu Ser Val Val Arg Arg Glu Thr His Ala Lys 
            20                  25                  30          


Ile Met Leu Ala Gly Arg Lys Cys Trp Asn Glu Gly Gly Arg Tyr Ile 
        35                  40                  45              


Gln Asn Val Leu Gly Val Arg Asn Ser Glu 
    50                  55              

<210>  2920
<211>  934
<212>  DNA
<213>  Homo sapiens

<400>  2920
aggaacacaa gactccggaa gcatgccagc gtataaaacc gtcaggagca atggctgacg     60

cctgtaatcc cagcattttg ggggcctaat cgggcagatt gcttgatgcc aggagttcga    120

gaccagcctg gccaacacgg taaagccgcg tctctactaa aaatacaaaa attagccaga    180

actgcacaaa caagccagaa actgaaccct acccggaatc ccctggtgta tgaagggagc    240

ctagctctgg ctgactctgc ttgtgttcac agacactttg cctcattggt tcgtgcctca    300

gcttccaatc tggacatgga gcacaataac agtgggccca ctgctctccg aattcctgcg    360

cgcacttgaa gggagtgtct ggtgcaggca tgcagggagg aagaatgact ctgagcttga    420

ccattcaact tcgaaacttt aacatcaatg gatcagcaca cactggtgta cggtctgcta    480

tgcatgcagc cctgtgctag gcaaaagaag tatcagacca ggaactgaca gcctcactgc    540

aacaggaaga gaggcttcac acaataagcg tttcattcaa ccaggctgga cctgtgctta    600

ttgagttgaa catcactgag cacaaaatgc aagccagaca ccataagagc tgtaaggatg    660

ataaagatgt ctttctaccc tcgagagctc taagtgtggt caggagagaa acacatgcaa    720

agattatgct ggctggaagg aaatgctgga atgaaggtgg aaggtacatc cagaatgttc    780

tgggggtgag gaatagcgaa tgatgggttc tgacttagaa catgaaggga aggtattaag    840

aaagaggtga tattaagcat ttattgagca tctctacttt ttttgtgtat gtgaccttgt    900

ttggaaatac aatatctctt cttgatgctg gcaa                                934


<210>  2921
<211>  87
<212>  PRT
<213>  Homo sapiens

<400>  2921


Met Pro Gly Val Arg Asp Gln Pro Gly Gln His Gly Lys Ala Ala Ser 
1               5                   10                  15      


Leu Leu Lys Ile Gln Lys Leu Ala Arg Thr Ala Gln Thr Ser Gln Lys 
            20                  25                  30          


Leu Asn Pro Thr Arg Asn Pro Leu Val Tyr Glu Gly Ser Leu Ala Leu 
        35                  40                  45              


Ala Asp Ser Ala Cys Val His Arg His Phe Ala Ser Leu Val Arg Ala 
    50                  55                  60                  


Ser Ala Ser Asn Leu Asp Met Glu His Asn Asn Ser Gly Pro Thr Ala 
65                  70                  75                  80  


Leu Arg Ile Pro Ala Arg Thr 
                85          

<210>  2922
<211>  2461
<212>  DNA
<213>  Homo sapiens

<400>  2922
ttggatacat gacgcagcaa ctgatgaacc tggcaggagg cgcagtggtg ctggccttgg     60

agggtggcca tgacctcaca gccatctgtg acgcctctga ggcctgtgtg gctgctcttc    120

tgggtaacag ggtgagccgt ctccctcccc catccatgct tctgtcaggc aggtaagccc    180

ggctctcagg actacccaag gagcaggcag atgggatggg acagggtggg agtggccaag    240

cctgaaacaa ggtaggcgaa gcggaagcct ctgttccaag ttaggtccag gcagcatctc    300

ctggcctagg tagagtgtgc ttgtggctag aaggctgggg cccctggggt gggagtgagc    360

tgggcctgtg ggtccctgag agactggtgg ctgatgtact gttttctata ggtggatccc    420

ctttcagaag aaggctggaa acagaaaccc aacctcaatg ccatccgctc tctggaggcc    480

gtgatccggg tgcacagtaa gtgtggagat gggacactcg ctgagctcag actgaaggat    540

cttggtggta ccctgcccca ccgtggccag atcctagggc ttccggtgcc agccaggtga    600

cctgctgttg gtctggagta agattcctgt gagtgaccca ggcagcaatg gtaaatactg    660

gggctgcatg cagcgcctgg cctcctgtcc agactcctgg gtgcctagag tgccaggggc    720

tgacaaagaa gaagtggagg cagtgaccgc actggcgtcc ctctctgtgg gcatcctggc    780

tgaagatagg ccctcggagc agctggtgga ggaggaagaa cctatgaatc tctaaggctc    840

tggaaccatc tgcccgccca ccatgccctt gggacctggt tctcttctaa cccctggcaa    900

tagcccccat tcctgggtct ttagagatcc tgtgggcaag tagttggaac cagagaacag    960

cctgcctgct ttgacagtta tcccagggag cgtgagaaaa tccctgggtc tagaatggga   1020

actggagagg accctgagag gagacgggct gggcggcgac ccccacaggg ctctcgagaa   1080

cagattctcc cctccagtat gggccctggc tgtggccccc attcctcagg actgcacaga   1140

ggaggactgg ctccggctcc gtcgggctca cccttaacca ctattcctgg ctctgcaaac   1200

cccagacttt gcacacagcc tcaggctcca cacagaaatg tgaacttggc ctcagacagg   1260

ctggcccttc ctaggctcta ggggctaggg gggagtgggg agccaagagg tcccatattc   1320

ctgagtgcag gggtagtccc tctcacctgc ttcctcagac gactctggaa gcttccctct   1380

accactgggc actgagacga agctccctga cagccgagac tggcagccct ccatctggtc   1440

cgtaccctcg ccagaggccc ccctacatca acctcctggc gatgccctgg tggagcagat   1500

gggtgctctg ggagtcctgt gcttcctgat ccaatggtgc caaacccttc atctccccaa   1560

gaagcgcagc atacccctgg gacccctcgg ccactgccca ctcggggagc cttctctgtt   1620

tctggggcct cccccaccat agctctgatt cccaccccac ataggagtag cctgactgag   1680

ggggaagggg tgggagagaa gatacagaca tggaggaggg gaggctgctc tggcaaagtc   1740

ttcaaggctt ttgggggtcc aggcctgggg tcaagaagga aaatgtgtgt gagcatgtgt   1800

gtgagtgagg cgtgtgtgtg agcgtgtgtg tgagtgaggc gtgtgtgtgt gtctttccta   1860

ggacccacca taccctgtgt atgtatgcat gtttttgtaa aaaggaagaa aatggaaaaa   1920

aatctgaaca ataaatgttt tatttgcttt aaaagtgcct ctgaaagggc cccccagaag   1980

tgagcagtgc gccgtcaagc gggtgtgcag ggcacacagc tgcacggcac agtgtgggtc   2040

tgagtcactg ccggaggagg gaccagggtg gtctgggccg cagccccttt aacaatctgc   2100

ccttcctgcc ctgcaggaag aacccattct gaacacaccc tggctgtccc tggctgcccc   2160

actttggggt gacaaagagg aggcagccct gggctgagtc cacagagacc agccctgata   2220

tggcaggagt gggggtgggg tgggggagtg ggaatacagg agctcagccc cagctcacca   2280

cggcatcccc gaagagttgt gactcagaca cacctgggtt taagtcccag ctgggagctc   2340

aggtaagtca aatcgtcttc tggggcctct gtttatcagt agaaggctcc agaagtatac   2400

actgttgatg gctccttccc gctctgatgc accatgcctg attaagcata cactgagcct   2460

a                                                                   2461


<210>  2923
<211>  55
<212>  PRT
<213>  Homo sapiens

<400>  2923


Met Gln Arg Leu Ala Ser Cys Pro Asp Ser Trp Val Pro Arg Val Pro 
1               5                   10                  15      


Gly Ala Asp Lys Glu Glu Val Glu Ala Val Thr Ala Leu Ala Ser Leu 
            20                  25                  30          


Ser Val Gly Ile Leu Ala Glu Asp Arg Pro Ser Glu Gln Leu Val Glu 
        35                  40                  45              


Glu Glu Glu Pro Met Asn Leu 
    50                  55  

<210>  2924
<211>  6925
<212>  DNA
<213>  Homo sapiens

<400>  2924
caccggcctc tgtcccgggc tcagtcttcc ccagccgcac ctgcctcact gtcagcccca     60

gagcctgcca gccaggcccg agtcctctcc agctcagaga cccctgccag gaccctgccc    120

ttcaccacag gtgagaccgg gaggagggtg gcgggtggag ggaggggctc ggctgcacga    180

gtccatgtgg gtgtcttggt gtcacttggg acatttttag aggccacaga gtgcttagcc    240

ttgttaggcc cacgtagtac ccatggagca catggaacag ctggttattg catttggccg    300

atgaggacca aggctcacga aatctaaggt gacaagcctg tggtcaaata gcaagtggta    360

gtcaagccag gataagaatt ccagtctcct gccaatgcac tcagcccttt taaaaaatga    420

tatttattac tgttgctctg cttgtaaaaa gagctcagaa gtattttaga cattttgaag    480

agtacagaaa aacctaagaa gaaaagaaaa atcaccaacc agtatcccac cacccagaag    540

taaaccctct gaaattctgc tgtatttcag tccaggcttt gttctggcca tatgtacatg    600

tacagatgcc atgaacacat gaactacgtt ttgtatcctg ctttacttag ttaacatatt    660

atgaatcctt cttggcataa ttagtcttta aaactgagag tctcatagta tttcattaat    720

gtatttcatt tttactgagg gatcccttat cagttagaca tttagattat agcttatttg    780

aatttcctta tgcataaatc tttcctcatg cttgggatta tttcccaagg ttcactctaa    840

agaagtagca ttcctgggtc acatggtgtg agcattttga gagtcgttgg tgtcctagac    900

gcacagaaat tgaccctccc acccgcaatg agcaggaccc tcctctgaag acttcccacg    960

ggtcagactg aaatagtcac ttctccaaag ctggatttgt ctatcacatg gtccagtgtc   1020

atcgtgggct tcttagctcc cggtttgggg gtttcctagg aattcttttc cctcctgctg   1080

ccccttggta gcctctctgg gttcatgaca cgtgtgtgag atgctgtacg ttaggcctca   1140

tgctttgctc tgagcacttg agggcctggt gctgggccct cgagtcctgg gccacccagc   1200

agtcgtgtcc gcatgtggga aggccgtggc tctgtggcag ccatgttggc tggagctgtg   1260

ttgatgtgtt ggctgctgcc acctggggaa gtgtctgggc gtgtgtggac aggtgtgagg   1320

ggctggggct ggggtagggg caggatgaaa tgcaggcctg tgtgggtgtg aggggtgtgt   1380

acccgcccgg ctccatgtgg gtgcctgctg tggcggtgct ggcgtgttct ctgcagccaa   1440

ggccatgggg cgtgaggact ccctgggtcc ccgctctgac ccttgctcct gcagggctga   1500

tctatgactc ggtcatgctg aagcaccagt gctcctgcgg tgacaacagc aggcacccgg   1560

agcacgccgg ccgcatccag agcatctggt cccggctgca ggagcggggg ctccggagcc   1620

agtgtgagtg tctccgaggc cggaaggcct ccctggaaga gctgcagtcg gtccactctg   1680

agcggcacgt gctcctctac ggcaccaacc cgctcagccg cctcaaactg gacaacggga   1740

agctggcagg gctcctggca cagcggatgt ttgtgatgct gccctgtggt ggggttgggg   1800

taagtgtgcc caggggtctc aggggggcgt tgccagggct ctcagctctc ctccctgtgg   1860

ttctcccagg cccagcccct gcagaacctc tgcttgttgt ggttctgcca gacagggtga   1920

gccagggact tcctgaggtg ccccctgcag caggaagctc cttttggaca ggcgtgtctc   1980

ggacccacag tctcccccga atgcggagtc cagcctaagc cttcccctag aaggtgtctg   2040

gtagatgttg agtgaggttt caggagcagg gccaaggctg gggcttagga tcatctctcc   2100

cttcaaagac ccccatgact gggcattggc cgccaggctg ctctgtctgc tcttaagtgg   2160

caagttgggg tacctcagcc tggtccccag accttgggct gcctggtgtg acatcacggt   2220

ggtgcttccg gtgtccttgg cgatcccagc actccccact ccgggacata gccccaaact   2280

ccgctcgcga gctttgcttc ctaagtcctc acccctttgt gaagggagct tcccgctccc   2340

tccggctcag ctctcctcgc ctaacactat ccctgcagta gtttctcaag caaggtgtgt   2400

agaggcaggg gatggaggcc tcattccgga gggaaagtgg gagctgtagc tggtggggga   2460

ctttgggagc cagtcagtgc cctattcaca acttcccatt tcttgccact ttctggtttt   2520

tccaactgtt gttgcttctg ttttctcctc cctcctctcc ctctctgtct ttctctctct   2580

ctctctttct ccagcctctt gcgactctct ctgccttcct cgcctctctt ggtctgcctc   2640

gccctcccca tctccccatc atgccccccg gcccctccct agccttgagg cccagggact   2700

gggtttgggg ggcctcccag cctgggctag gggccctgag tggaagacag tggtgcagac   2760

ggcccctcca gctccgaccg tcccgcaggg cctgagcaga gtcagctggg gcttaaaacc   2820

ccctcccggc ccaaacccca agtcccgccc aggtaacgcc atgccccctc ccctgaccgg   2880

ggaggcaggc gtgatgctgc cagcagagtg ctggccagat aatgggctgg tgctgggact   2940

taagctggga aaaagtcatg ctgggattgg gggacacagg aggccttgcc tttgggcggt   3000

ggggcactgg ggaggcagca ctgtctgccc agctccctgc ccctggggtc ctggccgtgg   3060

ggtggggacc acccccttgg gccctggctc ctgtgtgaag ccttggatga tgcgggccct   3120

gactctggct cccgcaggtg gacactgaca ccatctggaa tgagcttcat tcctccaatg   3180

cagcccgctg ggccgctggc agtgtcactg acctcgcctt caaagtggct tctcgtgagc   3240

taaagaatgg tttcgctgtg gtgcggcccc caggacacca tgcagatcat tcaacagcca   3300

tgggcttctg cttcttcaac tcagtggcca tcgcctgccg gcagctgcaa cagcagagca   3360

aggccagcaa gatcctcatt gtagactggg acgtgcacca tggcaacggc acccagcaaa   3420

ccttctacca agaccccagt gtgctctaca tctccctgca tcgccatgac gacggcaact   3480

tcttcccggg gagtggggct gtggatgagg taggggctgg cagcggtgag ggcttcaatg   3540

tcaatgtggc ctgggctgga ggtctggacc cccccatggg ggatcctgag tacctggctg   3600

ctttcaggat agtcgtgatg cccatcgccc gagagttctc tccagaccta gtcctggtgt   3660

ctgctggatt tgatgctgct gagggtcacc cggccccact gggtggctac catgtttctg   3720

ccaaatgttt tggatacatg acgcagcaac tgatgaacct ggcaggaggc gcagtggtgc   3780

tggccttgga gggtggccat gacctcacag ccatctgtga cgcctctgag gcctgtgtgg   3840

ctgctcttct gggtaacagg gtggatcccc tttcagaaga aggctggaaa cagaaaccca   3900

acctcaatgc catccgctct ctggaggccg tgatccgggt gcacagtaag tgtggagatg   3960

ggacactcgc tgagctcaga ctgaaggatc ttggtggtac cctgccccac cgtggccaga   4020

tcctagggct tccggtgcca gccaggtgac ctgctgttgg tctggagtaa gattcctgtg   4080

agtgacccag gcagcaatgg tgagcacccc ccagtgaggg gttatcctct gagccccccc   4140

gatggagcca gcagggccta ccagacagtg gcccctcaag gtagggactg gcctccatct   4200

ctagcgacag ccctagacca gggccaggtc aagagcaaca ctcaggcctt gtttgccaaa   4260

aggcctggtt cccatccctc ccctcagtcc tggccacagg cgtctcagga gctctgctgg   4320

cttgggggct gcgtcttggg ataaccccca catttgtaaa gtactttaaa ttttcaactt   4380

caactcaaca tctattgagc atcttatgtc aagacccata atctatacta gggataaaaa   4440

tgagtaaaat agattcccat atcaagggct gggtagggga gccgtgatgt ctttacataa   4500

tggtaaagac atggctgatt cctcttacgg tgggtgccct cacactgagc cagattccag   4560

gacatggttc ctcacagcag caggcaggag gagcattctc ctggcctggg cacccatgca   4620

gagcggccgt ggtgatggtc agttctccca tgttgtgttc gtcccacctc ccaggccctc   4680

ctttcctgag tgctgggctg agcactggtg ggggctgtgt ttaagtggga ggcccgagct   4740

tggggctctg ggaggtcact gtgacacaga ccctgtctgc aggcaagcag gctctcctga   4800

tgctctcagg agccccgcac ctgtggggaa tgagtcaaag gtggccttgc agccacaggg   4860

gatgagagaa aggctgggca cctgctagga ctccctcaca gccatgttga acccactctg   4920

tgtaccctgt caggctgtgc gggagtggga gcgaagtgag gagaggggca ggtgggagag   4980

ccgaccctaa gtggaggaca ggcccgctcc tccggggccc tgggcctgag acaccaacct   5040

caatatccgg tctaggacgc agtgtggagg ggcttgcttt ctccaaccct ttctgacctg   5100

gcatcttacc ccaggtaaat actggggctg catgcagcgc ctggcctcct gtccagactc   5160

ctgggtgcct agagtgccag gggctgacaa agaagaagtg gaggcagtga ccgcactggc   5220

gtccctctct gtgggcatcc tggctgaaga taggccctcg gagcagctgg tggaggagga   5280

agaacctatg aatctctaag gctctggaac catctgcccg cccaccatgc ccttgggacc   5340

tggttctctt ctaacccctg gcaatagccc ccattcctgg gtctttagag atcctgtggg   5400

caagtagttg gaaccagaga acagcctgcc tgctttgaca gttatcccag ggagcgtgag   5460

aaaatccctg ggtctagaat gggaactgga gaggaccctg agaggagacg ggctgggcgg   5520

cgacccccac agggctctcg agaacagatt ctcccctcca gtatgggccc tggctgtggc   5580

ccccattcct caggactgca cagaggagga ctggctccgg ctccgtcggg ctcaccctta   5640

accactattc ctggctctgc aaaccccaga ctttgcacac agcctcaggc tccacacaga   5700

aatgtgaact tggcctcaga caggctggcc cttcctaggc tctaggggct aggggggagt   5760

ggggagccaa gaggtcccat attcctgagt gcaggggtag tccctctcac ctgcttcctc   5820

agacgactct ggaagcttcc ctctaccact gggcactgag acgaagctcc ctgacagccg   5880

agactggcag ccctccatct ggtccgtacc ctcgccagag gcccccctac atcaacctcc   5940

tggcgatgcc ctggtggagc agatgggtgc tctgggagtc ctgtgcttcc tgatccaatg   6000

gtgccaaacc cttcatctcc ccaagaagcg cagcataccc ctgggacccc tcggccactg   6060

cccactcggg gagccttctc tgtttctggg gcctccccca ccatagctct gattcccacc   6120

ccacatagga gtagcctgac tgagggggaa ggggtgggag agaagataca gacatggagg   6180

aggggaggct gctctggcaa agtcttcaag gcttttgggg gtccaggcct ggggtcaaga   6240

aggaaaatgt gtgtgagcat gtgtgtgagt gaggcgtgtg tgtgagcgtg tgtgtgagtg   6300

aggcgtgtgt gtgtgtcttt cctaggaccc accataccct gtgtatgtat gcatgttttt   6360

gtaaaaagga agaaaatgga aaaaaatctg aacaataaat gttttatttg ctttaaaagt   6420

gcctctgaaa gggcccccca gaagtgagca gtgcgccgtc aagcgggtgt gcagggcaca   6480

cagctgcacg gcacagtgtg ggtctgagtc actgccggag gagggaccag ggtggtctgg   6540

gccgcagccc ctttaacaat ctgcccttcc tgccctgcag gaagaaccca ttctgaacac   6600

accctggctg tccctggctg ccccactttg gggtgacaaa gaggaggcag ccctgggctg   6660

agtccacaga gaccagccct gatatggcag gagtgggggt ggggtggggg agtgggaata   6720

caggagctca gccccagctc accacggcat ccccgaagag ttgtgactca gacacacctg   6780

ggtttaagtc ccagctggga gctcaggtaa gtcaaatcgt cttctggggc ctctgtttat   6840

cagtagaagg ctccagaagt atacactgtt gatggctcct tcccgctctg atgcaccatg   6900

cctgattaag catacactga gccta                                         6925


<210>  2925
<211>  249
<212>  PRT
<213>  Homo sapiens

<400>  2925


Met Gly Phe Cys Phe Phe Asn Ser Val Ala Ile Ala Cys Arg Gln Leu 
1               5                   10                  15      


Gln Gln Gln Ser Lys Ala Ser Lys Ile Leu Ile Val Asp Trp Asp Val 
            20                  25                  30          


His His Gly Asn Gly Thr Gln Gln Thr Phe Tyr Gln Asp Pro Ser Val 
        35                  40                  45              


Leu Tyr Ile Ser Leu His Arg His Asp Asp Gly Asn Phe Phe Pro Gly 
    50                  55                  60                  


Ser Gly Ala Val Asp Glu Val Gly Ala Gly Ser Gly Glu Gly Phe Asn 
65                  70                  75                  80  


Val Asn Val Ala Trp Ala Gly Gly Leu Asp Pro Pro Met Gly Asp Pro 
                85                  90                  95      


Glu Tyr Leu Ala Ala Phe Arg Ile Val Val Met Pro Ile Ala Arg Glu 
            100                 105                 110         


Phe Ser Pro Asp Leu Val Leu Val Ser Ala Gly Phe Asp Ala Ala Glu 
        115                 120                 125             


Gly His Pro Ala Pro Leu Gly Gly Tyr His Val Ser Ala Lys Cys Phe 
    130                 135                 140                 


Gly Tyr Met Thr Gln Gln Leu Met Asn Leu Ala Gly Gly Ala Val Val 
145                 150                 155                 160 


Leu Ala Leu Glu Gly Gly His Asp Leu Thr Ala Ile Cys Asp Ala Ser 
                165                 170                 175     


Glu Ala Cys Val Ala Ala Leu Leu Gly Asn Arg Val Asp Pro Leu Ser 
            180                 185                 190         


Glu Glu Gly Trp Lys Gln Lys Pro Asn Leu Asn Ala Ile Arg Ser Leu 
        195                 200                 205             


Glu Ala Val Ile Arg Val His Ser Lys Cys Gly Asp Gly Thr Leu Ala 
    210                 215                 220                 


Glu Leu Arg Leu Lys Asp Leu Gly Gly Thr Leu Pro His Arg Gly Gln 
225                 230                 235                 240 


Ile Leu Gly Leu Pro Val Pro Ala Arg 
                245                 

<210>  2926
<211>  4545
<212>  DNA
<213>  Homo sapiens

<400>  2926
aacccccatg agagtgtttt gccattgtca agtgagcctg agggaggctg aggggggatc     60

aggctgtatc atgcccccga ggacaaactt tccagtttac cctgctccct ctctctgtcc    120

ctaggctgcc ccaggccctg tgcagacaca ccaggccctc agccgcagcc catggacctg    180

cgggtgggcc agcggccccc agtggagccc ccaccagagc ccacattgct ggccctgcag    240

cgtccccagc gcctgcacca ccacctcttc ctagcaggcc tgcagcagca gcgctcggtg    300

gagcccatga ggctctccat ggacacgccg atgcccgagt tgcaggtggg accccaggaa    360

caagagctgc ggcagcttct ccacaaggac aagagcaagc gaagtgctgt agccagcagc    420

gtggtcaagc agaagctagc ggaggtgatt ctgaaaaaac agcaggcggc cctagaaaga    480

acagtccatc ccaacagccc cggcattccc tacagaaccc tggagcccct ggagacggaa    540

ggagccaccc gctccatgct cagcagcttt ttgcctcctg ttcccagcct gcccagtgac    600

cccccagagc acttccctct gcgcaagaca gtctctgagc ccaacctgaa gctgcgctat    660

aagcccaaga agtccctgga gcggaggaag aatccactgc tccgaaagga gagtgcgccc    720

cccagcctcc ggcggcggcc cgcagagacc ctcggagact cctccccaag tagtagcagc    780

acgcccgcat cagggtgcag ctcccccaat gacagcgagc acggccccaa tcccatcctg    840

ggctcggagg ctgacagtga ccgcaggacc catccgactc tgggccctcg ggggccaatc    900

ctggggagcc cccacactcc cctcttcctg ccccatggct tggagcccga ggctgggggc    960

accttgccct ctcgcctgca gcccattctc ctcctggacc cctcaggctc tcatgccccg   1020

ctgctgactg tgcccgggct tgggcccttg cccttccact ttgcccagtc cttaatgacc   1080

accgagcggc tctctgggtc aggcctccac tggccactga gccggactcg ctcagagccc   1140

ctgcccccca gtgccaccgc tcccccaccg ccgggcccca tgcagccccg cctggagcag   1200

ctcaaaactc acgtccaggt gatcaagagg tcagccaagc cgagtgagaa gccccggctg   1260

cggcagatac cctcggctga agacctggag acagatggcg ggggaccggg ccaggtggtg   1320

gacgatggcc tggagcacag ggagctgggc catgggcagc ctgaggccag aggccccgct   1380

cctctccagc agcaccctca ggtgttgctc tgggaacagc agcgactggc tgggcggctc   1440

ccccggggca gcaccgggga cactgtgctg cttcctctgg cccagggtgg gcaccggcct   1500

ctgtcccggg ctcagtcttc cccagccgca cctgcctcac tgtcagcccc agagcctgcc   1560

agccaggccc gagtcctctc cagctcagag acccctgcca ggaccctgcc cttcaccaca   1620

gggctgatct atgactcggt catgctgaag caccagtgct cctgcggtga caacagcagg   1680

cacccggagc acgccggccg catccagagc atctggtccc ggctgcagga gcgggggctc   1740

cggagccagt gtgagtgtct ccgaggccgg aaggcctccc tggaagagct gcagtcggtc   1800

cactctgagc ggcacgtgct cctctacggc accaacccgc tcagccgcct caaactggac   1860

aacgggaagc tggcagggct cctggcacag cggatgtttg tgatgctgcc ctgtggtggg   1920

gttggggtgg acactgacac catctggaat gagcttcatt cctccaatgc agcccgctgg   1980

gccgctggca gtgtcactga cctcgccttc aaagtggctt ctcgtgagct aaagaatggt   2040

ttcgctgtgg tgcggccccc aggacaccat gcagatcatt caacagccat gggcttctgc   2100

ttcttcaact cagtggccat cgcctgccgg cagctgcaac agcagagcaa ggccagcaag   2160

atcctcattg tagactggga cgtgcaccat ggcaacggca cccagcaaac cttctaccaa   2220

gaccccagtg tgctctacat ctccctgcat cgccatgacg acggcaactt cttcccgggg   2280

agtggggctg tggatgaggt aggggctggc agcggtgagg gcttcaatgt caatgtggcc   2340

tgggctggag gtctggaccc ccccatgggg gatcctgagt acctggctgc tttcaggata   2400

gtcgtgatgc ccatcgcccg agagttctct ccagacctag tcctggtgtc tgctggattt   2460

gatgctgctg agggtcaccc ggccccactg ggtggctacc atgtttctgc caaatgtttt   2520

ggatacatga cgcagcaact gatgaacctg gcaggaggcg cagtggtgct ggccttggag   2580

ggtggccatg acctcacagc catctgtgac gcctctgagg cctgtgtggc tgctcttctg   2640

ggtaacaggg tggatcccct ttcagaagaa ggctggaaac agaaacccaa cctcaatgcc   2700

atccgctctc tggaggccgt gatccgggtg cacagtaaat actggggctg catgcagcgc   2760

ctggcctcct gtccagactc ctgggtgcct agagtgccag gggctgacaa agaagaagtg   2820

gaggcagtga ccgcactggc gtccctctct gtgggcatcc tggctgaaga taggccctcg   2880

gagcagctgg tggaggagga agaacctatg aatctctaag gctctggaac catctgcccg   2940

cccaccatgc ccttgggacc tggttctctt ctaacccctg gcaatagccc ccattcctgg   3000

gtctttagag atcctgtggg caagtagttg gaaccagaga acagcctgcc tgctttgaca   3060

gttatcccag ggagcgtgag aaaatccctg ggtctagaat gggaactgga gaggaccctg   3120

agaggagacg ggctgggcgg cgacccccac agggctctcg agaacagatt ctcccctcca   3180

gtatgggccc tggctgtggc ccccattcct caggactgca cagaggagga ctggctccgg   3240

ctccgtcggg ctcaccctta accactattc ctggctctgc aaaccccaga ctttgcacac   3300

agcctcaggc tccacacaga aatgtgaact tggcctcaga caggctggcc cttcctaggc   3360

tctaggggct aggggggagt ggggagccaa gaggtcccat attcctgagt gcaggggtag   3420

tccctctcac ctgcttcctc agacgactct ggaagcttcc ctctaccact gggcactgag   3480

acgaagctcc ctgacagccg agactggcag ccctccatct ggtccgtacc ctcgccagag   3540

gcccccctac atcaacctcc tggcgatgcc ctggtggagc agatgggtgc tctgggagtc   3600

ctgtgcttcc tgatccaatg gtgccaaacc cttcatctcc ccaagaagcg cagcataccc   3660

ctgggacccc tcggccactg cccactcggg gagccttctc tgtttctggg gcctccccca   3720

ccatagctct gattcccacc ccacatagga gtagcctgac tgagggggaa ggggtgggag   3780

agaagataca gacatggagg aggggaggct gctctggcaa agtcttcaag gcttttgggg   3840

gtccaggcct ggggtcaaga aggaaaatgt gtgtgagcat gtgtgtgagt gaggcgtgtg   3900

tgtgagcgtg tgtgtgagtg aggcgtgtgt gtgtgtcttt cctaggaccc accataccct   3960

gtgtatgtat gcatgttttt gtaaaaagga agaaaatgga aaaaaatctg aacaataaat   4020

gttttatttg ctttaaaagt gcctctgaaa gggcccccca gaagtgagca gtgcgccgtc   4080

aagcgggtgt gcagggcaca cagctgcacg gcacagtgtg ggtctgagtc actgccggag   4140

gagggaccag ggtggtctgg gccgcagccc ctttaacaat ctgcccttcc tgccctgcag   4200

gaagaaccca ttctgaacac accctggctg tccctggctg ccccactttg gggtgacaaa   4260

gaggaggcag ccctgggctg agtccacaga gaccagccct gatatggcag gagtgggggt   4320

ggggtggggg agtgggaata caggagctca gccccagctc accacggcat ccccgaagag   4380

ttgtgactca gacacacctg ggtttaagtc ccagctggga gctcaggtaa gtcaaatcgt   4440

cttctggggc ctctgtttat cagtagaagg ctccagaagt atacactgtt gatggctcct   4500

tcccgctctg atgcaccatg cctgattaag catacactga gccta                   4545


<210>  2927
<211>  915
<212>  PRT
<213>  Homo sapiens

<400>  2927


Met Asp Leu Arg Val Gly Gln Arg Pro Pro Val Glu Pro Pro Pro Glu 
1               5                   10                  15      


Pro Thr Leu Leu Ala Leu Gln Arg Pro Gln Arg Leu His His His Leu 
            20                  25                  30          


Phe Leu Ala Gly Leu Gln Gln Gln Arg Ser Val Glu Pro Met Arg Leu 
        35                  40                  45              


Ser Met Asp Thr Pro Met Pro Glu Leu Gln Val Gly Pro Gln Glu Gln 
    50                  55                  60                  


Glu Leu Arg Gln Leu Leu His Lys Asp Lys Ser Lys Arg Ser Ala Val 
65                  70                  75                  80  


Ala Ser Ser Val Val Lys Gln Lys Leu Ala Glu Val Ile Leu Lys Lys 
                85                  90                  95      


Gln Gln Ala Ala Leu Glu Arg Thr Val His Pro Asn Ser Pro Gly Ile 
            100                 105                 110         


Pro Tyr Arg Thr Leu Glu Pro Leu Glu Thr Glu Gly Ala Thr Arg Ser 
        115                 120                 125             


Met Leu Ser Ser Phe Leu Pro Pro Val Pro Ser Leu Pro Ser Asp Pro 
    130                 135                 140                 


Pro Glu His Phe Pro Leu Arg Lys Thr Val Ser Glu Pro Asn Leu Lys 
145                 150                 155                 160 


Leu Arg Tyr Lys Pro Lys Lys Ser Leu Glu Arg Arg Lys Asn Pro Leu 
                165                 170                 175     


Leu Arg Lys Glu Ser Ala Pro Pro Ser Leu Arg Arg Arg Pro Ala Glu 
            180                 185                 190         


Thr Leu Gly Asp Ser Ser Pro Ser Ser Ser Ser Thr Pro Ala Ser Gly 
        195                 200                 205             


Cys Ser Ser Pro Asn Asp Ser Glu His Gly Pro Asn Pro Ile Leu Gly 
    210                 215                 220                 


Ser Glu Ala Asp Ser Asp Arg Arg Thr His Pro Thr Leu Gly Pro Arg 
225                 230                 235                 240 


Gly Pro Ile Leu Gly Ser Pro His Thr Pro Leu Phe Leu Pro His Gly 
                245                 250                 255     


Leu Glu Pro Glu Ala Gly Gly Thr Leu Pro Ser Arg Leu Gln Pro Ile 
            260                 265                 270         


Leu Leu Leu Asp Pro Ser Gly Ser His Ala Pro Leu Leu Thr Val Pro 
        275                 280                 285             


Gly Leu Gly Pro Leu Pro Phe His Phe Ala Gln Ser Leu Met Thr Thr 
    290                 295                 300                 


Glu Arg Leu Ser Gly Ser Gly Leu His Trp Pro Leu Ser Arg Thr Arg 
305                 310                 315                 320 


Ser Glu Pro Leu Pro Pro Ser Ala Thr Ala Pro Pro Pro Pro Gly Pro 
                325                 330                 335     


Met Gln Pro Arg Leu Glu Gln Leu Lys Thr His Val Gln Val Ile Lys 
            340                 345                 350         


Arg Ser Ala Lys Pro Ser Glu Lys Pro Arg Leu Arg Gln Ile Pro Ser 
        355                 360                 365             


Ala Glu Asp Leu Glu Thr Asp Gly Gly Gly Pro Gly Gln Val Val Asp 
    370                 375                 380                 


Asp Gly Leu Glu His Arg Glu Leu Gly His Gly Gln Pro Glu Ala Arg 
385                 390                 395                 400 


Gly Pro Ala Pro Leu Gln Gln His Pro Gln Val Leu Leu Trp Glu Gln 
                405                 410                 415     


Gln Arg Leu Ala Gly Arg Leu Pro Arg Gly Ser Thr Gly Asp Thr Val 
            420                 425                 430         


Leu Leu Pro Leu Ala Gln Gly Gly His Arg Pro Leu Ser Arg Ala Gln 
        435                 440                 445             


Ser Ser Pro Ala Ala Pro Ala Ser Leu Ser Ala Pro Glu Pro Ala Ser 
    450                 455                 460                 


Gln Ala Arg Val Leu Ser Ser Ser Glu Thr Pro Ala Arg Thr Leu Pro 
465                 470                 475                 480 


Phe Thr Thr Gly Leu Ile Tyr Asp Ser Val Met Leu Lys His Gln Cys 
                485                 490                 495     


Ser Cys Gly Asp Asn Ser Arg His Pro Glu His Ala Gly Arg Ile Gln 
            500                 505                 510         


Ser Ile Trp Ser Arg Leu Gln Glu Arg Gly Leu Arg Ser Gln Cys Glu 
        515                 520                 525             


Cys Leu Arg Gly Arg Lys Ala Ser Leu Glu Glu Leu Gln Ser Val His 
    530                 535                 540                 


Ser Glu Arg His Val Leu Leu Tyr Gly Thr Asn Pro Leu Ser Arg Leu 
545                 550                 555                 560 


Lys Leu Asp Asn Gly Lys Leu Ala Gly Leu Leu Ala Gln Arg Met Phe 
                565                 570                 575     


Val Met Leu Pro Cys Gly Gly Val Gly Val Asp Thr Asp Thr Ile Trp 
            580                 585                 590         


Asn Glu Leu His Ser Ser Asn Ala Ala Arg Trp Ala Ala Gly Ser Val 
        595                 600                 605             


Thr Asp Leu Ala Phe Lys Val Ala Ser Arg Glu Leu Lys Asn Gly Phe 
    610                 615                 620                 


Ala Val Val Arg Pro Pro Gly His His Ala Asp His Ser Thr Ala Met 
625                 630                 635                 640 


Gly Phe Cys Phe Phe Asn Ser Val Ala Ile Ala Cys Arg Gln Leu Gln 
                645                 650                 655     


Gln Gln Ser Lys Ala Ser Lys Ile Leu Ile Val Asp Trp Asp Val His 
            660                 665                 670         


His Gly Asn Gly Thr Gln Gln Thr Phe Tyr Gln Asp Pro Ser Val Leu 
        675                 680                 685             


Tyr Ile Ser Leu His Arg His Asp Asp Gly Asn Phe Phe Pro Gly Ser 
    690                 695                 700                 


Gly Ala Val Asp Glu Val Gly Ala Gly Ser Gly Glu Gly Phe Asn Val 
705                 710                 715                 720 


Asn Val Ala Trp Ala Gly Gly Leu Asp Pro Pro Met Gly Asp Pro Glu 
                725                 730                 735     


Tyr Leu Ala Ala Phe Arg Ile Val Val Met Pro Ile Ala Arg Glu Phe 
            740                 745                 750         


Ser Pro Asp Leu Val Leu Val Ser Ala Gly Phe Asp Ala Ala Glu Gly 
        755                 760                 765             


His Pro Ala Pro Leu Gly Gly Tyr His Val Ser Ala Lys Cys Phe Gly 
    770                 775                 780                 


Tyr Met Thr Gln Gln Leu Met Asn Leu Ala Gly Gly Ala Val Val Leu 
785                 790                 795                 800 


Ala Leu Glu Gly Gly His Asp Leu Thr Ala Ile Cys Asp Ala Ser Glu 
                805                 810                 815     


Ala Cys Val Ala Ala Leu Leu Gly Asn Arg Val Asp Pro Leu Ser Glu 
            820                 825                 830         


Glu Gly Trp Lys Gln Lys Pro Asn Leu Asn Ala Ile Arg Ser Leu Glu 
        835                 840                 845             


Ala Val Ile Arg Val His Ser Lys Tyr Trp Gly Cys Met Gln Arg Leu 
    850                 855                 860                 


Ala Ser Cys Pro Asp Ser Trp Val Pro Arg Val Pro Gly Ala Asp Lys 
865                 870                 875                 880 


Glu Glu Val Glu Ala Val Thr Ala Leu Ala Ser Leu Ser Val Gly Ile 
                885                 890                 895     


Leu Ala Glu Asp Arg Pro Ser Glu Gln Leu Val Glu Glu Glu Glu Pro 
            900                 905                 910         


Met Asn Leu 
        915 

<210>  2928
<211>  4667
<212>  DNA
<213>  Homo sapiens

<400>  2928
attgtcatcc tacccggccg gccgggctgc cagggccctc cccctcccgg ccccctccct     60

tcctctcgcc gtctcacagt cgctctgcag cctccggcga ctggggggat gtgaggccgg    120

cgccccagcc ccccgccccg ccatgagccc cccgctctga gggccccggc ccctggatgc    180

acagccccgg cgctgatggg acccaggtga gcccgggtgc ccactactgc agccccactg    240

gcgcaggctg ccccaggccc tgtgcagaca caccaggccc tcagccgcag cccatggacc    300

tgcgggtggg ccagcggccc ccagtggagc ccccaccaga gcccacattg ctggccctgc    360

agcgtcccca gcgcctgcac caccacctct tcctagcagg cctgcagcag cagcgctcgg    420

tggagcccat gaggctctcc atggacacgc cgatgcccga gttgcaggtg ggaccccagg    480

aacaagagct gcggcagctt ctccacaagg acaagagcaa gcgaagtgct gtagccagca    540

gcgtggtcaa gcagaagcta gcggaggtga ttctgaaaaa acagcaggcg gccctagaaa    600

gaacagtcca tcccaacagc cccggcattc cctacagaac cctggagccc ctggagacgg    660

aaggagccac ccgctccatg ctcagcagct ttttgcctcc tgttcccagc ctgcccagtg    720

accccccaga gcacttccct ctgcgcaaga cagtctctga gcccaacctg aagctgcgct    780

ataagcccaa gaagtccctg gagcggagga agaatccact gctccgaaag gagagtgcgc    840

cccccagcct ccggcggcgg cccgcagaga ccctcggaga ctcctcccca agtagtagca    900

gcacgcccgc atcagggtgc agctccccca atgacagcga gcacggcccc aatcccatcc    960

tgggctcgga ggctgacagt gaccgcagga cccatccgac tctgggccct cgggggccaa   1020

tcctggggag cccccacact cccctcttcc tgccccatgg cttggagccc gaggctgggg   1080

gcaccttgcc ctctcgcctg cagcccattc tcctcctgga cccctcaggc tctcatgccc   1140

cgctgctgac tgtgcccggg cttgggccct tgcccttcca ctttgcccag tccttaatga   1200

ccaccgagcg gctctctggg tcaggcctcc actggccact gagccggact cgctcagagc   1260

ccctgccccc cagtgccacc gctcccccac cgccgggccc catgcagccc cgcctggagc   1320

agctcaaaac tcacgtccag gtgatcaaga ggtcagccaa gccgagtgag aagccccggc   1380

tgcggcagat accctcggct gaagacctgg agacagatgg cgggggaccg ggccaggtgg   1440

tggacgatgg cctggagcac agggagctgg gccatgggca gcctgaggcc agaggccccg   1500

ctcctctcca gcagcaccct caggtgttgc tctgggaaca gcagcgactg gctgggcggc   1560

tcccccgggg cagcaccggg gacactgtgc tgcttcctct ggcccagggt gggcaccggc   1620

ctctgtcccg ggctcagtct tccccagccg cacctgcctc actgtcagcc ccagagcctg   1680

ccagccaggc ccgagtcctc tccagctcag agacccctgc caggaccctg cccttcacca   1740

cagggctgat ctatgactcg gtcatgctga agcaccagtg ctcctgcggt gacaacagca   1800

ggcacccgga gcacgccggc cgcatccaga gcatctggtc ccggctgcag gagcgggggc   1860

tccggagcca gtgtgagtgt ctccgaggcc ggaaggcctc cctggaagag ctgcagtcgg   1920

tccactctga gcggcacgtg ctcctctacg gcaccaaccc gctcagccgc ctcaaactgg   1980

acaacgggaa gctggcaggg ctcctggcac agcggatgtt tgtgatgctg ccctgtggtg   2040

gggttggggt ggacactgac accatctgga atgagcttca ttcctccaat gcagcccgct   2100

gggccgctgg cagtgtcact gacctcgcct tcaaagtggc ttctcgtgag ctaaagaatg   2160

gtttcgctgt ggtgcggccc ccaggacacc atgcagatca ttcaacagcc atgggcttct   2220

gcttcttcaa ctcagtggcc atcgcctgcc ggcagctgca acagcagagc aaggccagca   2280

agatcctcat tgtagactgg gacgtgcacc atggcaacgg cacccagcaa accttctacc   2340

aagaccccag tgtgctctac atctccctgc atcgccatga cgacggcaac ttcttcccgg   2400

ggagtggggc tgtggatgag gtaggggctg gcagcggtga gggcttcaat gtcaatgtgg   2460

cctgggctgg aggtctggac ccccccatgg gggatcctga gtacctggct gctttcagga   2520

tagtcgtgat gcccatcgcc cgagagttct ctccagacct agtcctggtg tctgctggat   2580

ttgatgctgc tgagggtcac ccggccccac tgggtggcta ccatgtttct gccaaatgtt   2640

ttggatacat gacgcagcaa ctgatgaacc tggcaggagg cgcagtggtg ctggccttgg   2700

agggtggcca tgacctcaca gccatctgtg acgcctctga ggcctgtgtg gctgctcttc   2760

tgggtaacag ggtggatccc ctttcagaag aaggctggaa acagaaaccc aacctcaatg   2820

ccatccgctc tctggaggcc gtgatccggg tgcacagtaa atactggggc tgcatgcagc   2880

gcctggcctc ctgtccagac tcctgggtgc ctagagtgcc aggggctgac aaagaagaag   2940

tggaggcagt gaccgcactg gcgtccctct ctgtgggcat cctggctgaa gataggccct   3000

cggagcagct ggtggaggag gaagaaccta tgaatctcta aggctctgga accatctgcc   3060

cgcccaccat gcccttggga cctggttctc ttctaacccc tggcaatagc ccccattcct   3120

gggtctttag agatcctgtg ggcaagtagt tggaaccaga gaacagcctg cctgctttga   3180

cagttatccc agggagcgtg agaaaatccc tgggtctaga atgggaactg gagaggaccc   3240

tgagaggaga cgggctgggc ggcgaccccc acagggctct cgagaacaga ttctcccctc   3300

cagtatgggc cctggctgtg gcccccattc ctcaggactg cacagaggag gactggctcc   3360

ggctccgtcg ggctcaccct taaccactat tcctggctct gcaaacccca gactttgcac   3420

acagcctcag gctccacaca gaaatgtgaa cttggcctca gacaggctgg cccttcctag   3480

gctctagggg ctagggggga gtggggagcc aagaggtccc atattcctga gtgcaggggt   3540

agtccctctc acctgcttcc tcagacgact ctggaagctt ccctctacca ctgggcactg   3600

agacgaagct ccctgacagc cgagactggc agccctccat ctggtccgta ccctcgccag   3660

aggcccccct acatcaacct cctggcgatg ccctggtgga gcagatgggt gctctgggag   3720

tcctgtgctt cctgatccaa tggtgccaaa cccttcatct ccccaagaag cgcagcatac   3780

ccctgggacc cctcggccac tgcccactcg gggagccttc tctgtttctg gggcctcccc   3840

caccatagct ctgattccca ccccacatag gagtagcctg actgaggggg aaggggtggg   3900

agagaagata cagacatgga ggaggggagg ctgctctggc aaagtcttca aggcttttgg   3960

gggtccaggc ctggggtcaa gaaggaaaat gtgtgtgagc atgtgtgtga gtgaggcgtg   4020

tgtgtgagcg tgtgtgtgag tgaggcgtgt gtgtgtgtct ttcctaggac ccaccatacc   4080

ctgtgtatgt atgcatgttt ttgtaaaaag gaagaaaatg gaaaaaaatc tgaacaataa   4140

atgttttatt tgctttaaaa gtgcctctga aagggccccc cagaagtgag cagtgcgccg   4200

tcaagcgggt gtgcagggca cacagctgca cggcacagtg tgggtctgag tcactgccgg   4260

aggagggacc agggtggtct gggccgcagc ccctttaaca atctgccctt cctgccctgc   4320

aggaagaacc cattctgaac acaccctggc tgtccctggc tgccccactt tggggtgaca   4380

aagaggaggc agccctgggc tgagtccaca gagaccagcc ctgatatggc aggagtgggg   4440

gtggggtggg ggagtgggaa tacaggagct cagccccagc tcaccacggc atccccgaag   4500

agttgtgact cagacacacc tgggtttaag tcccagctgg gagctcaggt aagtcaaatc   4560

gtcttctggg gcctctgttt atcagtagaa ggctccagaa gtatacactg ttgatggctc   4620

cttcccgctc tgatgcacca tgcctgatta agcatacact gagccta                 4667


<210>  2929
<211>  954
<212>  PRT
<213>  Homo sapiens

<400>  2929


Met His Ser Pro Gly Ala Asp Gly Thr Gln Val Ser Pro Gly Ala His 
1               5                   10                  15      


Tyr Cys Ser Pro Thr Gly Ala Gly Cys Pro Arg Pro Cys Ala Asp Thr 
            20                  25                  30          


Pro Gly Pro Gln Pro Gln Pro Met Asp Leu Arg Val Gly Gln Arg Pro 
        35                  40                  45              


Pro Val Glu Pro Pro Pro Glu Pro Thr Leu Leu Ala Leu Gln Arg Pro 
    50                  55                  60                  


Gln Arg Leu His His His Leu Phe Leu Ala Gly Leu Gln Gln Gln Arg 
65                  70                  75                  80  


Ser Val Glu Pro Met Arg Leu Ser Met Asp Thr Pro Met Pro Glu Leu 
                85                  90                  95      


Gln Val Gly Pro Gln Glu Gln Glu Leu Arg Gln Leu Leu His Lys Asp 
            100                 105                 110         


Lys Ser Lys Arg Ser Ala Val Ala Ser Ser Val Val Lys Gln Lys Leu 
        115                 120                 125             


Ala Glu Val Ile Leu Lys Lys Gln Gln Ala Ala Leu Glu Arg Thr Val 
    130                 135                 140                 


His Pro Asn Ser Pro Gly Ile Pro Tyr Arg Thr Leu Glu Pro Leu Glu 
145                 150                 155                 160 


Thr Glu Gly Ala Thr Arg Ser Met Leu Ser Ser Phe Leu Pro Pro Val 
                165                 170                 175     


Pro Ser Leu Pro Ser Asp Pro Pro Glu His Phe Pro Leu Arg Lys Thr 
            180                 185                 190         


Val Ser Glu Pro Asn Leu Lys Leu Arg Tyr Lys Pro Lys Lys Ser Leu 
        195                 200                 205             


Glu Arg Arg Lys Asn Pro Leu Leu Arg Lys Glu Ser Ala Pro Pro Ser 
    210                 215                 220                 


Leu Arg Arg Arg Pro Ala Glu Thr Leu Gly Asp Ser Ser Pro Ser Ser 
225                 230                 235                 240 


Ser Ser Thr Pro Ala Ser Gly Cys Ser Ser Pro Asn Asp Ser Glu His 
                245                 250                 255     


Gly Pro Asn Pro Ile Leu Gly Ser Glu Ala Asp Ser Asp Arg Arg Thr 
            260                 265                 270         


His Pro Thr Leu Gly Pro Arg Gly Pro Ile Leu Gly Ser Pro His Thr 
        275                 280                 285             


Pro Leu Phe Leu Pro His Gly Leu Glu Pro Glu Ala Gly Gly Thr Leu 
    290                 295                 300                 


Pro Ser Arg Leu Gln Pro Ile Leu Leu Leu Asp Pro Ser Gly Ser His 
305                 310                 315                 320 


Ala Pro Leu Leu Thr Val Pro Gly Leu Gly Pro Leu Pro Phe His Phe 
                325                 330                 335     


Ala Gln Ser Leu Met Thr Thr Glu Arg Leu Ser Gly Ser Gly Leu His 
            340                 345                 350         


Trp Pro Leu Ser Arg Thr Arg Ser Glu Pro Leu Pro Pro Ser Ala Thr 
        355                 360                 365             


Ala Pro Pro Pro Pro Gly Pro Met Gln Pro Arg Leu Glu Gln Leu Lys 
    370                 375                 380                 


Thr His Val Gln Val Ile Lys Arg Ser Ala Lys Pro Ser Glu Lys Pro 
385                 390                 395                 400 


Arg Leu Arg Gln Ile Pro Ser Ala Glu Asp Leu Glu Thr Asp Gly Gly 
                405                 410                 415     


Gly Pro Gly Gln Val Val Asp Asp Gly Leu Glu His Arg Glu Leu Gly 
            420                 425                 430         


His Gly Gln Pro Glu Ala Arg Gly Pro Ala Pro Leu Gln Gln His Pro 
        435                 440                 445             


Gln Val Leu Leu Trp Glu Gln Gln Arg Leu Ala Gly Arg Leu Pro Arg 
    450                 455                 460                 


Gly Ser Thr Gly Asp Thr Val Leu Leu Pro Leu Ala Gln Gly Gly His 
465                 470                 475                 480 


Arg Pro Leu Ser Arg Ala Gln Ser Ser Pro Ala Ala Pro Ala Ser Leu 
                485                 490                 495     


Ser Ala Pro Glu Pro Ala Ser Gln Ala Arg Val Leu Ser Ser Ser Glu 
            500                 505                 510         


Thr Pro Ala Arg Thr Leu Pro Phe Thr Thr Gly Leu Ile Tyr Asp Ser 
        515                 520                 525             


Val Met Leu Lys His Gln Cys Ser Cys Gly Asp Asn Ser Arg His Pro 
    530                 535                 540                 


Glu His Ala Gly Arg Ile Gln Ser Ile Trp Ser Arg Leu Gln Glu Arg 
545                 550                 555                 560 


Gly Leu Arg Ser Gln Cys Glu Cys Leu Arg Gly Arg Lys Ala Ser Leu 
                565                 570                 575     


Glu Glu Leu Gln Ser Val His Ser Glu Arg His Val Leu Leu Tyr Gly 
            580                 585                 590         


Thr Asn Pro Leu Ser Arg Leu Lys Leu Asp Asn Gly Lys Leu Ala Gly 
        595                 600                 605             


Leu Leu Ala Gln Arg Met Phe Val Met Leu Pro Cys Gly Gly Val Gly 
    610                 615                 620                 


Val Asp Thr Asp Thr Ile Trp Asn Glu Leu His Ser Ser Asn Ala Ala 
625                 630                 635                 640 


Arg Trp Ala Ala Gly Ser Val Thr Asp Leu Ala Phe Lys Val Ala Ser 
                645                 650                 655     


Arg Glu Leu Lys Asn Gly Phe Ala Val Val Arg Pro Pro Gly His His 
            660                 665                 670         


Ala Asp His Ser Thr Ala Met Gly Phe Cys Phe Phe Asn Ser Val Ala 
        675                 680                 685             


Ile Ala Cys Arg Gln Leu Gln Gln Gln Ser Lys Ala Ser Lys Ile Leu 
    690                 695                 700                 


Ile Val Asp Trp Asp Val His His Gly Asn Gly Thr Gln Gln Thr Phe 
705                 710                 715                 720 


Tyr Gln Asp Pro Ser Val Leu Tyr Ile Ser Leu His Arg His Asp Asp 
                725                 730                 735     


Gly Asn Phe Phe Pro Gly Ser Gly Ala Val Asp Glu Val Gly Ala Gly 
            740                 745                 750         


Ser Gly Glu Gly Phe Asn Val Asn Val Ala Trp Ala Gly Gly Leu Asp 
        755                 760                 765             


Pro Pro Met Gly Asp Pro Glu Tyr Leu Ala Ala Phe Arg Ile Val Val 
    770                 775                 780                 


Met Pro Ile Ala Arg Glu Phe Ser Pro Asp Leu Val Leu Val Ser Ala 
785                 790                 795                 800 


Gly Phe Asp Ala Ala Glu Gly His Pro Ala Pro Leu Gly Gly Tyr His 
                805                 810                 815     


Val Ser Ala Lys Cys Phe Gly Tyr Met Thr Gln Gln Leu Met Asn Leu 
            820                 825                 830         


Ala Gly Gly Ala Val Val Leu Ala Leu Glu Gly Gly His Asp Leu Thr 
        835                 840                 845             


Ala Ile Cys Asp Ala Ser Glu Ala Cys Val Ala Ala Leu Leu Gly Asn 
    850                 855                 860                 


Arg Val Asp Pro Leu Ser Glu Glu Gly Trp Lys Gln Lys Pro Asn Leu 
865                 870                 875                 880 


Asn Ala Ile Arg Ser Leu Glu Ala Val Ile Arg Val His Ser Lys Tyr 
                885                 890                 895     


Trp Gly Cys Met Gln Arg Leu Ala Ser Cys Pro Asp Ser Trp Val Pro 
            900                 905                 910         


Arg Val Pro Gly Ala Asp Lys Glu Glu Val Glu Ala Val Thr Ala Leu 
        915                 920                 925             


Ala Ser Leu Ser Val Gly Ile Leu Ala Glu Asp Arg Pro Ser Glu Gln 
    930                 935                 940                 


Leu Val Glu Glu Glu Glu Pro Met Asn Leu 
945                 950                 

<210>  2930
<211>  1963
<212>  DNA
<213>  Homo sapiens

<400>  2930
ttggatacat gacgcagcaa ctgatgaacc tggcaggagg cgcagtggtg ctggccttgg     60

agggtggcca tgacctcaca gccatctgtg acgcctctga ggcctgtgtg gctgctcttc    120

tgggtaacag ggtgagccgt ctccctcccc catccatgct tctgtcaggc aggtaagccc    180

ggctctcagg actacccaag gagcaggcag atgggatggg acagggtggg agtggccaag    240

cctgaaacaa ggtaggcgaa gcggaagcct ctgttccaag ttaggtccag gcagcatctc    300

ctggcctagg tagagtgtgc ttgtggctag aaggctgggg cccctggggt gggagtgagc    360

tgggcctgtg ggtccctgag agactggtgg ctgatgtact gttttctata ggtggatccc    420

ctttcagaag aaggctggaa acagaaaccc aacctcaatg ccatccgctc tctggaggcc    480

gtgatccggg tgcacagtaa gtgtggagat gggacactcg ctgagctcag actgaaggat    540

cttggtggta ccctgcccca ccgtggccag atcctagggc ttccggtgcc agccaggtga    600

cctgctgttg gtctggagta agattcctgt gagtgaccca ggcagcaatg gtaaatactg    660

gggctgcatg cagcgcctgg cctcctgtcc agactcctgg gtgcctagag tgccaggggc    720

tgacaaagaa gaagtggagg cagtgaccgc actggcgtcc ctctctgtgg gcatcctggc    780

tgaagatagg ccctcggagc agctggtgga ggaggaagaa cctatgaatc tctaaggctc    840

tggaaccatc tgcccgccca ccatgccctt gggacctggt tctcttctaa cccctggcaa    900

tagcccccat tcctgggtct ttagagatcc tgtgggcaag tagttggaac cagagaacag    960

cctgcctgct ttgacagtta tcccagggag cgtgagaaaa tccctgggtc tagaatggga   1020

actggagagg accctgagag gagacgggct gggcggcgac ccccacaggg ctctcgagaa   1080

cagattctcc cctccagtat gggccctggc tgtggccccc attcctcagg actgcacaga   1140

ggaggactgg ctccggctcc gtcgggctca cccttaacca ctattcctgg ctctgcaaac   1200

cccagacttt gcacacagcc tcaggctcca cacagaaatg tgaacttggc ctcagacagg   1260

ctggcccttc ctaggctcta ggggctaggg gggagtgggg agccaagagg tcccatattc   1320

ctgagtgcag gggtagtccc tctcacctgc ttcctcagac gactctggaa gcttccctct   1380

accactgggc actgagacga agctccctga cagccgagac tggcagccct ccatctggtc   1440

cgtaccctcg ccagaggccc ccctacatca acctcctggc gatgccctgg tggagcagat   1500

gggtgctctg ggagtcctgt gcttcctgat ccaatggtgc caaacccttc atctccccaa   1560

gaagcgcagc atacccctgg gacccctcgg ccactgccca ctcggggagc cttctctgtt   1620

tctggggcct cccccaccat agctctgatt cccaccccac ataggagtag cctgactgag   1680

ggggaagggg tgggagagaa gatacagaca tggaggaggg gaggctgctc tggcaaagtc   1740

ttcaaggctt ttgggggtcc aggcctgggg tcaagaagga aaatgtgtgt gagcatgtgt   1800

gtgagtgagg cgtgtgtgtg agcgtgtgtg tgagtgaggc gtgtgtgtgt gtctttccta   1860

ggacccacca taccctgtgt atgtatgcat gtttttgtaa aaaggaagaa aatggaaaaa   1920

aatctgaaca ataaatgttt tatttgcttt aaaagtgcct ctg                     1963


<210>  2931
<211>  55
<212>  PRT
<213>  Homo sapiens

<400>  2931


Met Gln Arg Leu Ala Ser Cys Pro Asp Ser Trp Val Pro Arg Val Pro 
1               5                   10                  15      


Gly Ala Asp Lys Glu Glu Val Glu Ala Val Thr Ala Leu Ala Ser Leu 
            20                  25                  30          


Ser Val Gly Ile Leu Ala Glu Asp Arg Pro Ser Glu Gln Leu Val Glu 
        35                  40                  45              


Glu Glu Glu Pro Met Asn Leu 
    50                  55  

<210>  2932
<211>  6427
<212>  DNA
<213>  Homo sapiens

<400>  2932
caccggcctc tgtcccgggc tcagtcttcc ccagccgcac ctgcctcact gtcagcccca     60

gagcctgcca gccaggcccg agtcctctcc agctcagaga cccctgccag gaccctgccc    120

ttcaccacag gtgagaccgg gaggagggtg gcgggtggag ggaggggctc ggctgcacga    180

gtccatgtgg gtgtcttggt gtcacttggg acatttttag aggccacaga gtgcttagcc    240

ttgttaggcc cacgtagtac ccatggagca catggaacag ctggttattg catttggccg    300

atgaggacca aggctcacga aatctaaggt gacaagcctg tggtcaaata gcaagtggta    360

gtcaagccag gataagaatt ccagtctcct gccaatgcac tcagcccttt taaaaaatga    420

tatttattac tgttgctctg cttgtaaaaa gagctcagaa gtattttaga cattttgaag    480

agtacagaaa aacctaagaa gaaaagaaaa atcaccaacc agtatcccac cacccagaag    540

taaaccctct gaaattctgc tgtatttcag tccaggcttt gttctggcca tatgtacatg    600

tacagatgcc atgaacacat gaactacgtt ttgtatcctg ctttacttag ttaacatatt    660

atgaatcctt cttggcataa ttagtcttta aaactgagag tctcatagta tttcattaat    720

gtatttcatt tttactgagg gatcccttat cagttagaca tttagattat agcttatttg    780

aatttcctta tgcataaatc tttcctcatg cttgggatta tttcccaagg ttcactctaa    840

agaagtagca ttcctgggtc acatggtgtg agcattttga gagtcgttgg tgtcctagac    900

gcacagaaat tgaccctccc acccgcaatg agcaggaccc tcctctgaag acttcccacg    960

ggtcagactg aaatagtcac ttctccaaag ctggatttgt ctatcacatg gtccagtgtc   1020

atcgtgggct tcttagctcc cggtttgggg gtttcctagg aattcttttc cctcctgctg   1080

ccccttggta gcctctctgg gttcatgaca cgtgtgtgag atgctgtacg ttaggcctca   1140

tgctttgctc tgagcacttg agggcctggt gctgggccct cgagtcctgg gccacccagc   1200

agtcgtgtcc gcatgtggga aggccgtggc tctgtggcag ccatgttggc tggagctgtg   1260

ttgatgtgtt ggctgctgcc acctggggaa gtgtctgggc gtgtgtggac aggtgtgagg   1320

ggctggggct ggggtagggg caggatgaaa tgcaggcctg tgtgggtgtg aggggtgtgt   1380

acccgcccgg ctccatgtgg gtgcctgctg tggcggtgct ggcgtgttct ctgcagccaa   1440

ggccatgggg cgtgaggact ccctgggtcc ccgctctgac ccttgctcct gcagggctga   1500

tctatgactc ggtcatgctg aagcaccagt gctcctgcgg tgacaacagc aggcacccgg   1560

agcacgccgg ccgcatccag agcatctggt cccggctgca ggagcggggg ctccggagcc   1620

agtgtgagtg tctccgaggc cggaaggcct ccctggaaga gctgcagtcg gtccactctg   1680

agcggcacgt gctcctctac ggcaccaacc cgctcagccg cctcaaactg gacaacggga   1740

agctggcagg gctcctggca cagcggatgt ttgtgatgct gccctgtggt ggggttgggg   1800

taagtgtgcc caggggtctc aggggggcgt tgccagggct ctcagctctc ctccctgtgg   1860

ttctcccagg cccagcccct gcagaacctc tgcttgttgt ggttctgcca gacagggtga   1920

gccagggact tcctgaggtg ccccctgcag caggaagctc cttttggaca ggcgtgtctc   1980

ggacccacag tctcccccga atgcggagtc cagcctaagc cttcccctag aaggtgtctg   2040

gtagatgttg agtgaggttt caggagcagg gccaaggctg gggcttagga tcatctctcc   2100

cttcaaagac ccccatgact gggcattggc cgccaggctg ctctgtctgc tcttaagtgg   2160

caagttgggg tacctcagcc tggtccccag accttgggct gcctggtgtg acatcacggt   2220

ggtgcttccg gtgtccttgg cgatcccagc actccccact ccgggacata gccccaaact   2280

ccgctcgcga gctttgcttc ctaagtcctc acccctttgt gaagggagct tcccgctccc   2340

tccggctcag ctctcctcgc ctaacactat ccctgcagta gtttctcaag caaggtgtgt   2400

agaggcaggg gatggaggcc tcattccgga gggaaagtgg gagctgtagc tggtggggga   2460

ctttgggagc cagtcagtgc cctattcaca acttcccatt tcttgccact ttctggtttt   2520

tccaactgtt gttgcttctg ttttctcctc cctcctctcc ctctctgtct ttctctctct   2580

ctctctttct ccagcctctt gcgactctct ctgccttcct cgcctctctt ggtctgcctc   2640

gccctcccca tctccccatc atgccccccg gcccctccct agccttgagg cccagggact   2700

gggtttgggg ggcctcccag cctgggctag gggccctgag tggaagacag tggtgcagac   2760

ggcccctcca gctccgaccg tcccgcaggg cctgagcaga gtcagctggg gcttaaaacc   2820

ccctcccggc ccaaacccca agtcccgccc aggtaacgcc atgccccctc ccctgaccgg   2880

ggaggcaggc gtgatgctgc cagcagagtg ctggccagat aatgggctgg tgctgggact   2940

taagctggga aaaagtcatg ctgggattgg gggacacagg aggccttgcc tttgggcggt   3000

ggggcactgg ggaggcagca ctgtctgccc agctccctgc ccctggggtc ctggccgtgg   3060

ggtggggacc acccccttgg gccctggctc ctgtgtgaag ccttggatga tgcgggccct   3120

gactctggct cccgcaggtg gacactgaca ccatctggaa tgagcttcat tcctccaatg   3180

cagcccgctg ggccgctggc agtgtcactg acctcgcctt caaagtggct tctcgtgagc   3240

taaagaatgg tttcgctgtg gtgcggcccc caggacacca tgcagatcat tcaacagcca   3300

tgggcttctg cttcttcaac tcagtggcca tcgcctgccg gcagctgcaa cagcagagca   3360

aggccagcaa gatcctcatt gtagactggg acgtgcacca tggcaacggc acccagcaaa   3420

ccttctacca agaccccagt gtgctctaca tctccctgca tcgccatgac gacggcaact   3480

tcttcccggg gagtggggct gtggatgagg taggggctgg cagcggtgag ggcttcaatg   3540

tcaatgtggc ctgggctgga ggtctggacc cccccatggg ggatcctgag tacctggctg   3600

ctttcaggat agtcgtgatg cccatcgccc gagagttctc tccagaccta gtcctggtgt   3660

ctgctggatt tgatgctgct gagggtcacc cggccccact gggtggctac catgtttctg   3720

ccaaatgttt tggatacatg acgcagcaac tgatgaacct ggcaggaggc gcagtggtgc   3780

tggccttgga gggtggccat gacctcacag ccatctgtga cgcctctgag gcctgtgtgg   3840

ctgctcttct gggtaacagg gtggatcccc tttcagaaga aggctggaaa cagaaaccca   3900

acctcaatgc catccgctct ctggaggccg tgatccgggt gcacagtaag tgtggagatg   3960

ggacactcgc tgagctcaga ctgaaggatc ttggtggtac cctgccccac cgtggccaga   4020

tcctagggct tccggtgcca gccaggtgac ctgctgttgg tctggagtaa gattcctgtg   4080

agtgacccag gcagcaatgg tgagcacccc ccagtgaggg gttatcctct gagccccccc   4140

gatggagcca gcagggccta ccagacagtg gcccctcaag gtagggactg gcctccatct   4200

ctagcgacag ccctagacca gggccaggtc aagagcaaca ctcaggcctt gtttgccaaa   4260

aggcctggtt cccatccctc ccctcagtcc tggccacagg cgtctcagga gctctgctgg   4320

cttgggggct gcgtcttggg ataaccccca catttgtaaa gtactttaaa ttttcaactt   4380

caactcaaca tctattgagc atcttatgtc aagacccata atctatacta gggataaaaa   4440

tgagtaaaat agattcccat atcaagggct gggtagggga gccgtgatgt ctttacataa   4500

tggtaaagac atggctgatt cctcttacgg tgggtgccct cacactgagc cagattccag   4560

gacatggttc ctcacagcag caggcaggag gagcattctc ctggcctggg cacccatgca   4620

gagcggccgt ggtgatggtc agttctccca tgttgtgttc gtcccacctc ccaggccctc   4680

ctttcctgag tgctgggctg agcactggtg ggggctgtgt ttaagtggga ggcccgagct   4740

tggggctctg ggaggtcact gtgacacaga ccctgtctgc aggcaagcag gctctcctga   4800

tgctctcagg agccccgcac ctgtggggaa tgagtcaaag gtggccttgc agccacaggg   4860

gatgagagaa aggctgggca cctgctagga ctccctcaca gccatgttga acccactctg   4920

tgtaccctgt caggctgtgc gggagtggga gcgaagtgag gagaggggca ggtgggagag   4980

ccgaccctaa gtggaggaca ggcccgctcc tccggggccc tgggcctgag acaccaacct   5040

caatatccgg tctaggacgc agtgtggagg ggcttgcttt ctccaaccct ttctgacctg   5100

gcatcttacc ccaggtaaat actggggctg catgcagcgc ctggcctcct gtccagactc   5160

ctgggtgcct agagtgccag gggctgacaa agaagaagtg gaggcagtga ccgcactggc   5220

gtccctctct gtgggcatcc tggctgaaga taggccctcg gagcagctgg tggaggagga   5280

agaacctatg aatctctaag gctctggaac catctgcccg cccaccatgc ccttgggacc   5340

tggttctctt ctaacccctg gcaatagccc ccattcctgg gtctttagag atcctgtggg   5400

caagtagttg gaaccagaga acagcctgcc tgctttgaca gttatcccag ggagcgtgag   5460

aaaatccctg ggtctagaat gggaactgga gaggaccctg agaggagacg ggctgggcgg   5520

cgacccccac agggctctcg agaacagatt ctcccctcca gtatgggccc tggctgtggc   5580

ccccattcct caggactgca cagaggagga ctggctccgg ctccgtcggg ctcaccctta   5640

accactattc ctggctctgc aaaccccaga ctttgcacac agcctcaggc tccacacaga   5700

aatgtgaact tggcctcaga caggctggcc cttcctaggc tctaggggct aggggggagt   5760

ggggagccaa gaggtcccat attcctgagt gcaggggtag tccctctcac ctgcttcctc   5820

agacgactct ggaagcttcc ctctaccact gggcactgag acgaagctcc ctgacagccg   5880

agactggcag ccctccatct ggtccgtacc ctcgccagag gcccccctac atcaacctcc   5940

tggcgatgcc ctggtggagc agatgggtgc tctgggagtc ctgtgcttcc tgatccaatg   6000

gtgccaaacc cttcatctcc ccaagaagcg cagcataccc ctgggacccc tcggccactg   6060

cccactcggg gagccttctc tgtttctggg gcctccccca ccatagctct gattcccacc   6120

ccacatagga gtagcctgac tgagggggaa ggggtgggag agaagataca gacatggagg   6180

aggggaggct gctctggcaa agtcttcaag gcttttgggg gtccaggcct ggggtcaaga   6240

aggaaaatgt gtgtgagcat gtgtgtgagt gaggcgtgtg tgtgagcgtg tgtgtgagtg   6300

aggcgtgtgt gtgtgtcttt cctaggaccc accataccct gtgtatgtat gcatgttttt   6360

gtaaaaagga agaaaatgga aaaaaatctg aacaataaat gttttatttg ctttaaaagt   6420

gcctctg                                                             6427


<210>  2933
<211>  249
<212>  PRT
<213>  Homo sapiens

<400>  2933


Met Gly Phe Cys Phe Phe Asn Ser Val Ala Ile Ala Cys Arg Gln Leu 
1               5                   10                  15      


Gln Gln Gln Ser Lys Ala Ser Lys Ile Leu Ile Val Asp Trp Asp Val 
            20                  25                  30          


His His Gly Asn Gly Thr Gln Gln Thr Phe Tyr Gln Asp Pro Ser Val 
        35                  40                  45              


Leu Tyr Ile Ser Leu His Arg His Asp Asp Gly Asn Phe Phe Pro Gly 
    50                  55                  60                  


Ser Gly Ala Val Asp Glu Val Gly Ala Gly Ser Gly Glu Gly Phe Asn 
65                  70                  75                  80  


Val Asn Val Ala Trp Ala Gly Gly Leu Asp Pro Pro Met Gly Asp Pro 
                85                  90                  95      


Glu Tyr Leu Ala Ala Phe Arg Ile Val Val Met Pro Ile Ala Arg Glu 
            100                 105                 110         


Phe Ser Pro Asp Leu Val Leu Val Ser Ala Gly Phe Asp Ala Ala Glu 
        115                 120                 125             


Gly His Pro Ala Pro Leu Gly Gly Tyr His Val Ser Ala Lys Cys Phe 
    130                 135                 140                 


Gly Tyr Met Thr Gln Gln Leu Met Asn Leu Ala Gly Gly Ala Val Val 
145                 150                 155                 160 


Leu Ala Leu Glu Gly Gly His Asp Leu Thr Ala Ile Cys Asp Ala Ser 
                165                 170                 175     


Glu Ala Cys Val Ala Ala Leu Leu Gly Asn Arg Val Asp Pro Leu Ser 
            180                 185                 190         


Glu Glu Gly Trp Lys Gln Lys Pro Asn Leu Asn Ala Ile Arg Ser Leu 
        195                 200                 205             


Glu Ala Val Ile Arg Val His Ser Lys Cys Gly Asp Gly Thr Leu Ala 
    210                 215                 220                 


Glu Leu Arg Leu Lys Asp Leu Gly Gly Thr Leu Pro His Arg Gly Gln 
225                 230                 235                 240 


Ile Leu Gly Leu Pro Val Pro Ala Arg 
                245                 

<210>  2934
<211>  4091
<212>  DNA
<213>  Homo sapiens

<400>  2934
ataataccta ccttgcagga ccacgacagg attaagtgag gaaaaacccc catgagagtg     60

ttttgccatt gtcaagtgag cctgagggag gctgaggggg gatcaggctg tatcatgccc    120

ccgaggacaa actttccagt ttaccctgct ccctctctct gtccctaggc tgccccaggc    180

cctgtgcaga cacaccaggc cctcagccgc agcccatgga cctgcgggtg ggccagcggc    240

ccccagtgga gcccccacca gagcccacat tgctggccct gcagcgtccc cagcgcctgc    300

accaccacct cttcctagca ggcctgcagc agcagcgctc ggtggagccc atgaggctct    360

ccatggacac gccgatgccc gagttgcagg tgggacccca ggaacaagag ctgcggcagc    420

ttctccacaa ggacaagagc aagcgaagtg ctgtagccag cagcgtggtc aagcagaagc    480

tagcggaggt gattctgaaa aaacagcagg cggccctaga aagaacagtc catcccaaca    540

gccccggcat tccctacaga accctggagc ccctggagac ggaaggagcc acccgctcca    600

tgctcagcag ctttttgcct cctgttccca gcctgcccag tgacccccca gagcacttcc    660

ctctgcgcaa gacagtctct gagcccaacc tgaagctgcg ctataagccc aagaagtccc    720

tggagcggag gaagaatcca ctgctccgaa aggagagtgc gccccccagc ctccggcggc    780

ggcccgcaga gaccctcgga gactcctccc caagtagtag cagcacgccc gcatcagggt    840

gcagctcccc caatgacagc gagcacggcc ccaatcccat cctgggctcg gaggctgaca    900

gtgaccgcag gacccatccg actctgggcc ctcgggggcc aatcctgggg agcccccaca    960

ctcccctctt cctgccccat ggcttggagc ccgaggctgg gggcaccttg ccctctcgcc   1020

tgcagcccat tctcctcctg gacccctcag gctctcatgc cccgctgctg actgtgcccg   1080

ggcttgggcc cttgcccttc cactttgccc agtccttaat gaccaccgag cggctctctg   1140

ggtcaggcct ccactggcca ctgagccgga ctcgctcaga gcccctgccc cccagtgcca   1200

ccgctccccc accgccgggc cccatgcagc cccgcctgga gcagctcaaa actcacgtcc   1260

aggtgatcaa gaggtcagcc aagccgagtg agaagccccg gctgcggcag ataccctcgg   1320

ctgaagacct ggagacagat ggcgggggac cgggccaggt ggtggacgat ggcctggagc   1380

acagggagct gggccatggg cagcctgagg ccagaggccc cgctcctctc cagcagcacc   1440

ctcaggtgtt gctctgggaa cagcagcgac tggctgggcg gctcccccgg ggcagcaccg   1500

gggacactgt gctgcttcct ctggcccagg gtgggcaccg gcctctgtcc cgggctcagt   1560

cttccccagc cgcacctgcc tcactgtcag ccccagagcc tgccagccag gcccgagtcc   1620

tctccagctc agagacccct gccaggaccc tgcccttcac cacagggctg atctatgact   1680

cggtcatgct gaagcaccag tgctcctgcg gtgacaacag caggcacccg gagcacgccg   1740

gccgcatcca gagcatctgg tcccggctgc aggagcgggg gctccggagc cagtgtgagt   1800

gtctccgagg ccggaaggcc tccctggaag agctgcagtc ggtccactct gagcggcacg   1860

tgctcctcta cggcaccaac ccgctcagcc gcctcaaact ggacaacggg aagctggcag   1920

ggctcctggc acagcggatg tttgtgatgc tgccctgtgg tggggttggg gtggacactg   1980

acaccatctg gaatgagctt cattcctcca atgcagcccg ctgggccgct ggcagtgtca   2040

ctgacctcgc cttcaaagtg gcttctcgtg agctaaagaa tggtttcgct gtggtgcggc   2100

ccccaggaca ccatgcagat cattcaacag ccatgggctt ctgcttcttc aactcagtgg   2160

ccatcgcctg ccggcagctg caacagcaga gcaaggccag caagatcctc attgtagact   2220

gggacgtgca ccatggcaac ggcacccagc aaaccttcta ccaagacccc agtgtgctct   2280

acatctccct gcatcgccat gacgacggca acttcttccc ggggagtggg gctgtggatg   2340

aggtaggggc tggcagcggt gagggcttca atgtcaatgt ggcctgggct ggaggtctgg   2400

acccccccat gggggatcct gagtacctgg ctgctttcag gatagtcgtg atgcccatcg   2460

cccgagagtt ctctccagac ctagtcctgg tgtctgctgg atttgatgct gctgagggtc   2520

acccggcccc actgggtggc taccatgttt ctgccaaatg ttttggatac atgacgcagc   2580

aactgatgaa cctggcagga ggcgcagtgg tgctggcctt ggagggtggc catgacctca   2640

cagccatctg tgacgcctct gaggcctgtg tggctgctct tctgggtaac agggtggatc   2700

ccctttcaga agaaggctgg aaacagaaac ccaacctcaa tgccatccgc tctctggagg   2760

ccgtgatccg ggtgcacagt aaatactggg gctgcatgca gcgcctggcc tcctgtccag   2820

actcctgggt gcctagagtg ccaggggctg acaaagaaga agtggaggca gtgaccgcac   2880

tggcgtccct ctctgtgggc atcctggctg aagataggcc ctcggagcag ctggtggagg   2940

aggaagaacc tatgaatctc taaggctctg gaaccatctg cccgcccacc atgcccttgg   3000

gacctggttc tcttctaacc cctggcaata gcccccattc ctgggtcttt agagatcctg   3060

tgggcaagta gttggaacca gagaacagcc tgcctgcttt gacagttatc ccagggagcg   3120

tgagaaaatc cctgggtcta gaatgggaac tggagaggac cctgagagga gacgggctgg   3180

gcggcgaccc ccacagggct ctcgagaaca gattctcccc tccagtatgg gccctggctg   3240

tggcccccat tcctcaggac tgcacagagg aggactggct ccggctccgt cgggctcacc   3300

cttaaccact attcctggct ctgcaaaccc cagactttgc acacagcctc aggctccaca   3360

cagaaatgtg aacttggcct cagacaggct ggcccttcct aggctctagg ggctaggggg   3420

gagtggggag ccaagaggtc ccatattcct gagtgcaggg gtagtccctc tcacctgctt   3480

cctcagacga ctctggaagc ttccctctac cactgggcac tgagacgaag ctccctgaca   3540

gccgagactg gcagccctcc atctggtccg taccctcgcc agaggccccc ctacatcaac   3600

ctcctggcga tgccctggtg gagcagatgg gtgctctggg agtcctgtgc ttcctgatcc   3660

aatggtgcca aacccttcat ctccccaaga agcgcagcat acccctggga cccctcggcc   3720

actgcccact cggggagcct tctctgtttc tggggcctcc cccaccatag ctctgattcc   3780

caccccacat aggagtagcc tgactgaggg ggaaggggtg ggagagaaga tacagacatg   3840

gaggagggga ggctgctctg gcaaagtctt caaggctttt gggggtccag gcctggggtc   3900

aagaaggaaa atgtgtgtga gcatgtgtgt gagtgaggcg tgtgtgtgag cgtgtgtgtg   3960

agtgaggcgt gtgtgtgtgt ctttcctagg acccaccata ccctgtgtat gtatgcatgt   4020

ttttgtaaaa aggaagaaaa tggaaaaaaa tctgaacaat aaatgtttta tttgctttaa   4080

aagtgcctct g                                                        4091


<210>  2935
<211>  915
<212>  PRT
<213>  Homo sapiens

<400>  2935


Met Asp Leu Arg Val Gly Gln Arg Pro Pro Val Glu Pro Pro Pro Glu 
1               5                   10                  15      


Pro Thr Leu Leu Ala Leu Gln Arg Pro Gln Arg Leu His His His Leu 
            20                  25                  30          


Phe Leu Ala Gly Leu Gln Gln Gln Arg Ser Val Glu Pro Met Arg Leu 
        35                  40                  45              


Ser Met Asp Thr Pro Met Pro Glu Leu Gln Val Gly Pro Gln Glu Gln 
    50                  55                  60                  


Glu Leu Arg Gln Leu Leu His Lys Asp Lys Ser Lys Arg Ser Ala Val 
65                  70                  75                  80  


Ala Ser Ser Val Val Lys Gln Lys Leu Ala Glu Val Ile Leu Lys Lys 
                85                  90                  95      


Gln Gln Ala Ala Leu Glu Arg Thr Val His Pro Asn Ser Pro Gly Ile 
            100                 105                 110         


Pro Tyr Arg Thr Leu Glu Pro Leu Glu Thr Glu Gly Ala Thr Arg Ser 
        115                 120                 125             


Met Leu Ser Ser Phe Leu Pro Pro Val Pro Ser Leu Pro Ser Asp Pro 
    130                 135                 140                 


Pro Glu His Phe Pro Leu Arg Lys Thr Val Ser Glu Pro Asn Leu Lys 
145                 150                 155                 160 


Leu Arg Tyr Lys Pro Lys Lys Ser Leu Glu Arg Arg Lys Asn Pro Leu 
                165                 170                 175     


Leu Arg Lys Glu Ser Ala Pro Pro Ser Leu Arg Arg Arg Pro Ala Glu 
            180                 185                 190         


Thr Leu Gly Asp Ser Ser Pro Ser Ser Ser Ser Thr Pro Ala Ser Gly 
        195                 200                 205             


Cys Ser Ser Pro Asn Asp Ser Glu His Gly Pro Asn Pro Ile Leu Gly 
    210                 215                 220                 


Ser Glu Ala Asp Ser Asp Arg Arg Thr His Pro Thr Leu Gly Pro Arg 
225                 230                 235                 240 


Gly Pro Ile Leu Gly Ser Pro His Thr Pro Leu Phe Leu Pro His Gly 
                245                 250                 255     


Leu Glu Pro Glu Ala Gly Gly Thr Leu Pro Ser Arg Leu Gln Pro Ile 
            260                 265                 270         


Leu Leu Leu Asp Pro Ser Gly Ser His Ala Pro Leu Leu Thr Val Pro 
        275                 280                 285             


Gly Leu Gly Pro Leu Pro Phe His Phe Ala Gln Ser Leu Met Thr Thr 
    290                 295                 300                 


Glu Arg Leu Ser Gly Ser Gly Leu His Trp Pro Leu Ser Arg Thr Arg 
305                 310                 315                 320 


Ser Glu Pro Leu Pro Pro Ser Ala Thr Ala Pro Pro Pro Pro Gly Pro 
                325                 330                 335     


Met Gln Pro Arg Leu Glu Gln Leu Lys Thr His Val Gln Val Ile Lys 
            340                 345                 350         


Arg Ser Ala Lys Pro Ser Glu Lys Pro Arg Leu Arg Gln Ile Pro Ser 
        355                 360                 365             


Ala Glu Asp Leu Glu Thr Asp Gly Gly Gly Pro Gly Gln Val Val Asp 
    370                 375                 380                 


Asp Gly Leu Glu His Arg Glu Leu Gly His Gly Gln Pro Glu Ala Arg 
385                 390                 395                 400 


Gly Pro Ala Pro Leu Gln Gln His Pro Gln Val Leu Leu Trp Glu Gln 
                405                 410                 415     


Gln Arg Leu Ala Gly Arg Leu Pro Arg Gly Ser Thr Gly Asp Thr Val 
            420                 425                 430         


Leu Leu Pro Leu Ala Gln Gly Gly His Arg Pro Leu Ser Arg Ala Gln 
        435                 440                 445             


Ser Ser Pro Ala Ala Pro Ala Ser Leu Ser Ala Pro Glu Pro Ala Ser 
    450                 455                 460                 


Gln Ala Arg Val Leu Ser Ser Ser Glu Thr Pro Ala Arg Thr Leu Pro 
465                 470                 475                 480 


Phe Thr Thr Gly Leu Ile Tyr Asp Ser Val Met Leu Lys His Gln Cys 
                485                 490                 495     


Ser Cys Gly Asp Asn Ser Arg His Pro Glu His Ala Gly Arg Ile Gln 
            500                 505                 510         


Ser Ile Trp Ser Arg Leu Gln Glu Arg Gly Leu Arg Ser Gln Cys Glu 
        515                 520                 525             


Cys Leu Arg Gly Arg Lys Ala Ser Leu Glu Glu Leu Gln Ser Val His 
    530                 535                 540                 


Ser Glu Arg His Val Leu Leu Tyr Gly Thr Asn Pro Leu Ser Arg Leu 
545                 550                 555                 560 


Lys Leu Asp Asn Gly Lys Leu Ala Gly Leu Leu Ala Gln Arg Met Phe 
                565                 570                 575     


Val Met Leu Pro Cys Gly Gly Val Gly Val Asp Thr Asp Thr Ile Trp 
            580                 585                 590         


Asn Glu Leu His Ser Ser Asn Ala Ala Arg Trp Ala Ala Gly Ser Val 
        595                 600                 605             


Thr Asp Leu Ala Phe Lys Val Ala Ser Arg Glu Leu Lys Asn Gly Phe 
    610                 615                 620                 


Ala Val Val Arg Pro Pro Gly His His Ala Asp His Ser Thr Ala Met 
625                 630                 635                 640 


Gly Phe Cys Phe Phe Asn Ser Val Ala Ile Ala Cys Arg Gln Leu Gln 
                645                 650                 655     


Gln Gln Ser Lys Ala Ser Lys Ile Leu Ile Val Asp Trp Asp Val His 
            660                 665                 670         


His Gly Asn Gly Thr Gln Gln Thr Phe Tyr Gln Asp Pro Ser Val Leu 
        675                 680                 685             


Tyr Ile Ser Leu His Arg His Asp Asp Gly Asn Phe Phe Pro Gly Ser 
    690                 695                 700                 


Gly Ala Val Asp Glu Val Gly Ala Gly Ser Gly Glu Gly Phe Asn Val 
705                 710                 715                 720 


Asn Val Ala Trp Ala Gly Gly Leu Asp Pro Pro Met Gly Asp Pro Glu 
                725                 730                 735     


Tyr Leu Ala Ala Phe Arg Ile Val Val Met Pro Ile Ala Arg Glu Phe 
            740                 745                 750         


Ser Pro Asp Leu Val Leu Val Ser Ala Gly Phe Asp Ala Ala Glu Gly 
        755                 760                 765             


His Pro Ala Pro Leu Gly Gly Tyr His Val Ser Ala Lys Cys Phe Gly 
    770                 775                 780                 


Tyr Met Thr Gln Gln Leu Met Asn Leu Ala Gly Gly Ala Val Val Leu 
785                 790                 795                 800 


Ala Leu Glu Gly Gly His Asp Leu Thr Ala Ile Cys Asp Ala Ser Glu 
                805                 810                 815     


Ala Cys Val Ala Ala Leu Leu Gly Asn Arg Val Asp Pro Leu Ser Glu 
            820                 825                 830         


Glu Gly Trp Lys Gln Lys Pro Asn Leu Asn Ala Ile Arg Ser Leu Glu 
        835                 840                 845             


Ala Val Ile Arg Val His Ser Lys Tyr Trp Gly Cys Met Gln Arg Leu 
    850                 855                 860                 


Ala Ser Cys Pro Asp Ser Trp Val Pro Arg Val Pro Gly Ala Asp Lys 
865                 870                 875                 880 


Glu Glu Val Glu Ala Val Thr Ala Leu Ala Ser Leu Ser Val Gly Ile 
                885                 890                 895     


Leu Ala Glu Asp Arg Pro Ser Glu Gln Leu Val Glu Glu Glu Glu Pro 
            900                 905                 910         


Met Asn Leu 
        915 

<210>  2936
<211>  4202
<212>  DNA
<213>  Homo sapiens

<400>  2936
ataataccta ccttgcagga ccacgacagg attaagtgag gaaaaacccc catgagagtg     60

ttttgccatt gtcaagtgag cctgagggag gctgaggggg gatcaggctg tatcatgccc    120

ccgaggacaa actttccagt ttaccctgct ccctctctct gtccctaggc tgccccaggc    180

cctgtgcaga cacaccaggc cctcagccgc agcccatgga cctgcgggtg ggccagcggc    240

ccccagtgga gcccccacca gagcccacat tgctggccct gcagcgtccc cagcgcctgc    300

accaccacct cttcctagca ggcctgcagc agcagcgctc ggtggagccc atgaggctct    360

ccatggacac gccgatgccc gagttgcagg tgggacccca ggaacaagag ctgcggcagc    420

ttctccacaa ggacaagagc aagcgaagtg ctgtagccag cagcgtggtc aagcagaagc    480

tagcggaggt gattctgaaa aaacagcagg cggccctaga aagaacagtc catcccaaca    540

gccccggcat tccctacaga accctggagc ccctggagac ggaaggagcc acccgctcca    600

tgctcagcag ctttttgcct cctgttccca gcctgcccag tgacccccca gagcacttcc    660

ctctgcgcaa gacagtctct gagcccaacc tgaagctgcg ctataagccc aagaagtccc    720

tggagcggag gaagaatcca ctgctccgaa aggagagtgc gccccccagc ctccggcggc    780

ggcccgcaga gaccctcgga gactcctccc caagtagtag cagcacgccc gcatcagggt    840

gcagctcccc caatgacagc gagcacggcc ccaatcccat cctgggctcg gaggcgctct    900

tgggccagcg gctgcggctg caggagactt ctgtggcccc gttcgccttg ccgacagtgt    960

ccttgctgcc cgcaatcact ctggggctgc ccgcccctgc cagggctgac agtgaccgca   1020

ggacccatcc gactctgggc cctcgggggc caatcctggg gagcccccac actcccctct   1080

tcctgcccca tggcttggag cccgaggctg ggggcacctt gccctctcgc ctgcagccca   1140

ttctcctcct ggacccctca ggctctcatg ccccgctgct gactgtgccc gggcttgggc   1200

ccttgccctt ccactttgcc cagtccttaa tgaccaccga gcggctctct gggtcaggcc   1260

tccactggcc actgagccgg actcgctcag agcccctgcc ccccagtgcc accgctcccc   1320

caccgccggg ccccatgcag ccccgcctgg agcagctcaa aactcacgtc caggtgatca   1380

agaggtcagc caagccgagt gagaagcccc ggctgcggca gataccctcg gctgaagacc   1440

tggagacaga tggcggggga ccgggccagg tggtggacga tggcctggag cacagggagc   1500

tgggccatgg gcagcctgag gccagaggcc ccgctcctct ccagcagcac cctcaggtgt   1560

tgctctggga acagcagcga ctggctgggc ggctcccccg gggcagcacc ggggacactg   1620

tgctgcttcc tctggcccag ggtgggcacc ggcctctgtc ccgggctcag tcttccccag   1680

ccgcacctgc ctcactgtca gccccagagc ctgccagcca ggcccgagtc ctctccagct   1740

cagagacccc tgccaggacc ctgcccttca ccacagggct gatctatgac tcggtcatgc   1800

tgaagcacca gtgctcctgc ggtgacaaca gcaggcaccc ggagcacgcc ggccgcatcc   1860

agagcatctg gtcccggctg caggagcggg ggctccggag ccagtgtgag tgtctccgag   1920

gccggaaggc ctccctggaa gagctgcagt cggtccactc tgagcggcac gtgctcctct   1980

acggcaccaa cccgctcagc cgcctcaaac tggacaacgg gaagctggca gggctcctgg   2040

cacagcggat gtttgtgatg ctgccctgtg gtggggttgg ggtggacact gacaccatct   2100

ggaatgagct tcattcctcc aatgcagccc gctgggccgc tggcagtgtc actgacctcg   2160

ccttcaaagt ggcttctcgt gagctaaaga atggtttcgc tgtggtgcgg cccccaggac   2220

accatgcaga tcattcaaca gccatgggct tctgcttctt caactcagtg gccatcgcct   2280

gccggcagct gcaacagcag agcaaggcca gcaagatcct cattgtagac tgggacgtgc   2340

accatggcaa cggcacccag caaaccttct accaagaccc cagtgtgctc tacatctccc   2400

tgcatcgcca tgacgacggc aacttcttcc cggggagtgg ggctgtggat gaggtagggg   2460

ctggcagcgg tgagggcttc aatgtcaatg tggcctgggc tggaggtctg gaccccccca   2520

tgggggatcc tgagtacctg gctgctttca ggatagtcgt gatgcccatc gcccgagagt   2580

tctctccaga cctagtcctg gtgtctgctg gatttgatgc tgctgagggt cacccggccc   2640

cactgggtgg ctaccatgtt tctgccaaat gttttggata catgacgcag caactgatga   2700

acctggcagg aggcgcagtg gtgctggcct tggagggtgg ccatgacctc acagccatct   2760

gtgacgcctc tgaggcctgt gtggctgctc ttctgggtaa cagggtggat cccctttcag   2820

aagaaggctg gaaacagaaa cccaacctca atgccatccg ctctctggag gccgtgatcc   2880

gggtgcacag taaatactgg ggctgcatgc agcgcctggc ctcctgtcca gactcctggg   2940

tgcctagagt gccaggggct gacaaagaag aagtggaggc agtgaccgca ctggcgtccc   3000

tctctgtggg catcctggct gaagataggc cctcggagca gctggtggag gaggaagaac   3060

ctatgaatct ctaaggctct ggaaccatct gcccgcccac catgcccttg ggacctggtt   3120

ctcttctaac ccctggcaat agcccccatt cctgggtctt tagagatcct gtgggcaagt   3180

agttggaacc agagaacagc ctgcctgctt tgacagttat cccagggagc gtgagaaaat   3240

ccctgggtct agaatgggaa ctggagagga ccctgagagg agacgggctg ggcggcgacc   3300

cccacagggc tctcgagaac agattctccc ctccagtatg ggccctggct gtggccccca   3360

ttcctcagga ctgcacagag gaggactggc tccggctccg tcgggctcac ccttaaccac   3420

tattcctggc tctgcaaacc ccagactttg cacacagcct caggctccac acagaaatgt   3480

gaacttggcc tcagacaggc tggcccttcc taggctctag gggctagggg ggagtgggga   3540

gccaagaggt cccatattcc tgagtgcagg ggtagtccct ctcacctgct tcctcagacg   3600

actctggaag cttccctcta ccactgggca ctgagacgaa gctccctgac agccgagact   3660

ggcagccctc catctggtcc gtaccctcgc cagaggcccc cctacatcaa cctcctggcg   3720

atgccctggt ggagcagatg ggtgctctgg gagtcctgtg cttcctgatc caatggtgcc   3780

aaacccttca tctccccaag aagcgcagca tacccctggg acccctcggc cactgcccac   3840

tcggggagcc ttctctgttt ctggggcctc ccccaccata gctctgattc ccaccccaca   3900

taggagtagc ctgactgagg gggaaggggt gggagagaag atacagacat ggaggagggg   3960

aggctgctct ggcaaagtct tcaaggcttt tgggggtcca ggcctggggt caagaaggaa   4020

aatgtgtgtg agcatgtgtg tgagtgaggc gtgtgtgtga gcgtgtgtgt gagtgaggcg   4080

tgtgtgtgtg tctttcctag gacccaccat accctgtgta tgtatgcatg tttttgtaaa   4140

aaggaagaaa atggaaaaaa atctgaacaa taaatgtttt atttgcttta aaagtgcctc   4200

tg                                                                  4202


<210>  2937
<211>  952
<212>  PRT
<213>  Homo sapiens

<400>  2937


Met Asp Leu Arg Val Gly Gln Arg Pro Pro Val Glu Pro Pro Pro Glu 
1               5                   10                  15      


Pro Thr Leu Leu Ala Leu Gln Arg Pro Gln Arg Leu His His His Leu 
            20                  25                  30          


Phe Leu Ala Gly Leu Gln Gln Gln Arg Ser Val Glu Pro Met Arg Leu 
        35                  40                  45              


Ser Met Asp Thr Pro Met Pro Glu Leu Gln Val Gly Pro Gln Glu Gln 
    50                  55                  60                  


Glu Leu Arg Gln Leu Leu His Lys Asp Lys Ser Lys Arg Ser Ala Val 
65                  70                  75                  80  


Ala Ser Ser Val Val Lys Gln Lys Leu Ala Glu Val Ile Leu Lys Lys 
                85                  90                  95      


Gln Gln Ala Ala Leu Glu Arg Thr Val His Pro Asn Ser Pro Gly Ile 
            100                 105                 110         


Pro Tyr Arg Thr Leu Glu Pro Leu Glu Thr Glu Gly Ala Thr Arg Ser 
        115                 120                 125             


Met Leu Ser Ser Phe Leu Pro Pro Val Pro Ser Leu Pro Ser Asp Pro 
    130                 135                 140                 


Pro Glu His Phe Pro Leu Arg Lys Thr Val Ser Glu Pro Asn Leu Lys 
145                 150                 155                 160 


Leu Arg Tyr Lys Pro Lys Lys Ser Leu Glu Arg Arg Lys Asn Pro Leu 
                165                 170                 175     


Leu Arg Lys Glu Ser Ala Pro Pro Ser Leu Arg Arg Arg Pro Ala Glu 
            180                 185                 190         


Thr Leu Gly Asp Ser Ser Pro Ser Ser Ser Ser Thr Pro Ala Ser Gly 
        195                 200                 205             


Cys Ser Ser Pro Asn Asp Ser Glu His Gly Pro Asn Pro Ile Leu Gly 
    210                 215                 220                 


Ser Glu Ala Leu Leu Gly Gln Arg Leu Arg Leu Gln Glu Thr Ser Val 
225                 230                 235                 240 


Ala Pro Phe Ala Leu Pro Thr Val Ser Leu Leu Pro Ala Ile Thr Leu 
                245                 250                 255     


Gly Leu Pro Ala Pro Ala Arg Ala Asp Ser Asp Arg Arg Thr His Pro 
            260                 265                 270         


Thr Leu Gly Pro Arg Gly Pro Ile Leu Gly Ser Pro His Thr Pro Leu 
        275                 280                 285             


Phe Leu Pro His Gly Leu Glu Pro Glu Ala Gly Gly Thr Leu Pro Ser 
    290                 295                 300                 


Arg Leu Gln Pro Ile Leu Leu Leu Asp Pro Ser Gly Ser His Ala Pro 
305                 310                 315                 320 


Leu Leu Thr Val Pro Gly Leu Gly Pro Leu Pro Phe His Phe Ala Gln 
                325                 330                 335     


Ser Leu Met Thr Thr Glu Arg Leu Ser Gly Ser Gly Leu His Trp Pro 
            340                 345                 350         


Leu Ser Arg Thr Arg Ser Glu Pro Leu Pro Pro Ser Ala Thr Ala Pro 
        355                 360                 365             


Pro Pro Pro Gly Pro Met Gln Pro Arg Leu Glu Gln Leu Lys Thr His 
    370                 375                 380                 


Val Gln Val Ile Lys Arg Ser Ala Lys Pro Ser Glu Lys Pro Arg Leu 
385                 390                 395                 400 


Arg Gln Ile Pro Ser Ala Glu Asp Leu Glu Thr Asp Gly Gly Gly Pro 
                405                 410                 415     


Gly Gln Val Val Asp Asp Gly Leu Glu His Arg Glu Leu Gly His Gly 
            420                 425                 430         


Gln Pro Glu Ala Arg Gly Pro Ala Pro Leu Gln Gln His Pro Gln Val 
        435                 440                 445             


Leu Leu Trp Glu Gln Gln Arg Leu Ala Gly Arg Leu Pro Arg Gly Ser 
    450                 455                 460                 


Thr Gly Asp Thr Val Leu Leu Pro Leu Ala Gln Gly Gly His Arg Pro 
465                 470                 475                 480 


Leu Ser Arg Ala Gln Ser Ser Pro Ala Ala Pro Ala Ser Leu Ser Ala 
                485                 490                 495     


Pro Glu Pro Ala Ser Gln Ala Arg Val Leu Ser Ser Ser Glu Thr Pro 
            500                 505                 510         


Ala Arg Thr Leu Pro Phe Thr Thr Gly Leu Ile Tyr Asp Ser Val Met 
        515                 520                 525             


Leu Lys His Gln Cys Ser Cys Gly Asp Asn Ser Arg His Pro Glu His 
    530                 535                 540                 


Ala Gly Arg Ile Gln Ser Ile Trp Ser Arg Leu Gln Glu Arg Gly Leu 
545                 550                 555                 560 


Arg Ser Gln Cys Glu Cys Leu Arg Gly Arg Lys Ala Ser Leu Glu Glu 
                565                 570                 575     


Leu Gln Ser Val His Ser Glu Arg His Val Leu Leu Tyr Gly Thr Asn 
            580                 585                 590         


Pro Leu Ser Arg Leu Lys Leu Asp Asn Gly Lys Leu Ala Gly Leu Leu 
        595                 600                 605             


Ala Gln Arg Met Phe Val Met Leu Pro Cys Gly Gly Val Gly Val Asp 
    610                 615                 620                 


Thr Asp Thr Ile Trp Asn Glu Leu His Ser Ser Asn Ala Ala Arg Trp 
625                 630                 635                 640 


Ala Ala Gly Ser Val Thr Asp Leu Ala Phe Lys Val Ala Ser Arg Glu 
                645                 650                 655     


Leu Lys Asn Gly Phe Ala Val Val Arg Pro Pro Gly His His Ala Asp 
            660                 665                 670         


His Ser Thr Ala Met Gly Phe Cys Phe Phe Asn Ser Val Ala Ile Ala 
        675                 680                 685             


Cys Arg Gln Leu Gln Gln Gln Ser Lys Ala Ser Lys Ile Leu Ile Val 
    690                 695                 700                 


Asp Trp Asp Val His His Gly Asn Gly Thr Gln Gln Thr Phe Tyr Gln 
705                 710                 715                 720 


Asp Pro Ser Val Leu Tyr Ile Ser Leu His Arg His Asp Asp Gly Asn 
                725                 730                 735     


Phe Phe Pro Gly Ser Gly Ala Val Asp Glu Val Gly Ala Gly Ser Gly 
            740                 745                 750         


Glu Gly Phe Asn Val Asn Val Ala Trp Ala Gly Gly Leu Asp Pro Pro 
        755                 760                 765             


Met Gly Asp Pro Glu Tyr Leu Ala Ala Phe Arg Ile Val Val Met Pro 
    770                 775                 780                 


Ile Ala Arg Glu Phe Ser Pro Asp Leu Val Leu Val Ser Ala Gly Phe 
785                 790                 795                 800 


Asp Ala Ala Glu Gly His Pro Ala Pro Leu Gly Gly Tyr His Val Ser 
                805                 810                 815     


Ala Lys Cys Phe Gly Tyr Met Thr Gln Gln Leu Met Asn Leu Ala Gly 
            820                 825                 830         


Gly Ala Val Val Leu Ala Leu Glu Gly Gly His Asp Leu Thr Ala Ile 
        835                 840                 845             


Cys Asp Ala Ser Glu Ala Cys Val Ala Ala Leu Leu Gly Asn Arg Val 
    850                 855                 860                 


Asp Pro Leu Ser Glu Glu Gly Trp Lys Gln Lys Pro Asn Leu Asn Ala 
865                 870                 875                 880 


Ile Arg Ser Leu Glu Ala Val Ile Arg Val His Ser Lys Tyr Trp Gly 
                885                 890                 895     


Cys Met Gln Arg Leu Ala Ser Cys Pro Asp Ser Trp Val Pro Arg Val 
            900                 905                 910         


Pro Gly Ala Asp Lys Glu Glu Val Glu Ala Val Thr Ala Leu Ala Ser 
        915                 920                 925             


Leu Ser Val Gly Ile Leu Ala Glu Asp Arg Pro Ser Glu Gln Leu Val 
    930                 935                 940                 


Glu Glu Glu Glu Pro Met Asn Leu 
945                 950         

<210>  2938
<211>  4169
<212>  DNA
<213>  Homo sapiens

<400>  2938
attgtcatcc tacccggccg gccgggctgc cagggccctc cccctcccgg ccccctccct     60

tcctctcgcc gtctcacagt cgctctgcag cctccggcga ctggggggat gtgaggccgg    120

cgccccagcc ccccgccccg ccatgagccc cccgctctga gggccccggc ccctggatgc    180

acagccccgg cgctgatggg acccaggtga gcccgggtgc ccactactgc agccccactg    240

gcgcaggctg ccccaggccc tgtgcagaca caccaggccc tcagccgcag cccatggacc    300

tgcgggtggg ccagcggccc ccagtggagc ccccaccaga gcccacattg ctggccctgc    360

agcgtcccca gcgcctgcac caccacctct tcctagcagg cctgcagcag cagcgctcgg    420

tggagcccat gaggctctcc atggacacgc cgatgcccga gttgcaggtg ggaccccagg    480

aacaagagct gcggcagctt ctccacaagg acaagagcaa gcgaagtgct gtagccagca    540

gcgtggtcaa gcagaagcta gcggaggtga ttctgaaaaa acagcaggcg gccctagaaa    600

gaacagtcca tcccaacagc cccggcattc cctacagaac cctggagccc ctggagacgg    660

aaggagccac ccgctccatg ctcagcagct ttttgcctcc tgttcccagc ctgcccagtg    720

accccccaga gcacttccct ctgcgcaaga cagtctctga gcccaacctg aagctgcgct    780

ataagcccaa gaagtccctg gagcggagga agaatccact gctccgaaag gagagtgcgc    840

cccccagcct ccggcggcgg cccgcagaga ccctcggaga ctcctcccca agtagtagca    900

gcacgcccgc atcagggtgc agctccccca atgacagcga gcacggcccc aatcccatcc    960

tgggctcgga ggctgacagt gaccgcagga cccatccgac tctgggccct cgggggccaa   1020

tcctggggag cccccacact cccctcttcc tgccccatgg cttggagccc gaggctgggg   1080

gcaccttgcc ctctcgcctg cagcccattc tcctcctgga cccctcaggc tctcatgccc   1140

cgctgctgac tgtgcccggg cttgggccct tgcccttcca ctttgcccag tccttaatga   1200

ccaccgagcg gctctctggg tcaggcctcc actggccact gagccggact cgctcagagc   1260

ccctgccccc cagtgccacc gctcccccac cgccgggccc catgcagccc cgcctggagc   1320

agctcaaaac tcacgtccag gtgatcaaga ggtcagccaa gccgagtgag aagccccggc   1380

tgcggcagat accctcggct gaagacctgg agacagatgg cgggggaccg ggccaggtgg   1440

tggacgatgg cctggagcac agggagctgg gccatgggca gcctgaggcc agaggccccg   1500

ctcctctcca gcagcaccct caggtgttgc tctgggaaca gcagcgactg gctgggcggc   1560

tcccccgggg cagcaccggg gacactgtgc tgcttcctct ggcccagggt gggcaccggc   1620

ctctgtcccg ggctcagtct tccccagccg cacctgcctc actgtcagcc ccagagcctg   1680

ccagccaggc ccgagtcctc tccagctcag agacccctgc caggaccctg cccttcacca   1740

cagggctgat ctatgactcg gtcatgctga agcaccagtg ctcctgcggt gacaacagca   1800

ggcacccgga gcacgccggc cgcatccaga gcatctggtc ccggctgcag gagcgggggc   1860

tccggagcca gtgtgagtgt ctccgaggcc ggaaggcctc cctggaagag ctgcagtcgg   1920

tccactctga gcggcacgtg ctcctctacg gcaccaaccc gctcagccgc ctcaaactgg   1980

acaacgggaa gctggcaggg ctcctggcac agcggatgtt tgtgatgctg ccctgtggtg   2040

gggttggggt ggacactgac accatctgga atgagcttca ttcctccaat gcagcccgct   2100

gggccgctgg cagtgtcact gacctcgcct tcaaagtggc ttctcgtgag ctaaagaatg   2160

gtttcgctgt ggtgcggccc ccaggacacc atgcagatca ttcaacagcc atgggcttct   2220

gcttcttcaa ctcagtggcc atcgcctgcc ggcagctgca acagcagagc aaggccagca   2280

agatcctcat tgtagactgg gacgtgcacc atggcaacgg cacccagcaa accttctacc   2340

aagaccccag tgtgctctac atctccctgc atcgccatga cgacggcaac ttcttcccgg   2400

ggagtggggc tgtggatgag gtaggggctg gcagcggtga gggcttcaat gtcaatgtgg   2460

cctgggctgg aggtctggac ccccccatgg gggatcctga gtacctggct gctttcagga   2520

tagtcgtgat gcccatcgcc cgagagttct ctccagacct agtcctggtg tctgctggat   2580

ttgatgctgc tgagggtcac ccggccccac tgggtggcta ccatgtttct gccaaatgtt   2640

ttggatacat gacgcagcaa ctgatgaacc tggcaggagg cgcagtggtg ctggccttgg   2700

agggtggcca tgacctcaca gccatctgtg acgcctctga ggcctgtgtg gctgctcttc   2760

tgggtaacag ggtggatccc ctttcagaag aaggctggaa acagaaaccc aacctcaatg   2820

ccatccgctc tctggaggcc gtgatccggg tgcacagtaa atactggggc tgcatgcagc   2880

gcctggcctc ctgtccagac tcctgggtgc ctagagtgcc aggggctgac aaagaagaag   2940

tggaggcagt gaccgcactg gcgtccctct ctgtgggcat cctggctgaa gataggccct   3000

cggagcagct ggtggaggag gaagaaccta tgaatctcta aggctctgga accatctgcc   3060

cgcccaccat gcccttggga cctggttctc ttctaacccc tggcaatagc ccccattcct   3120

gggtctttag agatcctgtg ggcaagtagt tggaaccaga gaacagcctg cctgctttga   3180

cagttatccc agggagcgtg agaaaatccc tgggtctaga atgggaactg gagaggaccc   3240

tgagaggaga cgggctgggc ggcgaccccc acagggctct cgagaacaga ttctcccctc   3300

cagtatgggc cctggctgtg gcccccattc ctcaggactg cacagaggag gactggctcc   3360

ggctccgtcg ggctcaccct taaccactat tcctggctct gcaaacccca gactttgcac   3420

acagcctcag gctccacaca gaaatgtgaa cttggcctca gacaggctgg cccttcctag   3480

gctctagggg ctagggggga gtggggagcc aagaggtccc atattcctga gtgcaggggt   3540

agtccctctc acctgcttcc tcagacgact ctggaagctt ccctctacca ctgggcactg   3600

agacgaagct ccctgacagc cgagactggc agccctccat ctggtccgta ccctcgccag   3660

aggcccccct acatcaacct cctggcgatg ccctggtgga gcagatgggt gctctgggag   3720

tcctgtgctt cctgatccaa tggtgccaaa cccttcatct ccccaagaag cgcagcatac   3780

ccctgggacc cctcggccac tgcccactcg gggagccttc tctgtttctg gggcctcccc   3840

caccatagct ctgattccca ccccacatag gagtagcctg actgaggggg aaggggtggg   3900

agagaagata cagacatgga ggaggggagg ctgctctggc aaagtcttca aggcttttgg   3960

gggtccaggc ctggggtcaa gaaggaaaat gtgtgtgagc atgtgtgtga gtgaggcgtg   4020

tgtgtgagcg tgtgtgtgag tgaggcgtgt gtgtgtgtct ttcctaggac ccaccatacc   4080

ctgtgtatgt atgcatgttt ttgtaaaaag gaagaaaatg gaaaaaaatc tgaacaataa   4140

atgttttatt tgctttaaaa gtgcctctg                                     4169


<210>  2939
<211>  954
<212>  PRT
<213>  Homo sapiens

<400>  2939


Met His Ser Pro Gly Ala Asp Gly Thr Gln Val Ser Pro Gly Ala His 
1               5                   10                  15      


Tyr Cys Ser Pro Thr Gly Ala Gly Cys Pro Arg Pro Cys Ala Asp Thr 
            20                  25                  30          


Pro Gly Pro Gln Pro Gln Pro Met Asp Leu Arg Val Gly Gln Arg Pro 
        35                  40                  45              


Pro Val Glu Pro Pro Pro Glu Pro Thr Leu Leu Ala Leu Gln Arg Pro 
    50                  55                  60                  


Gln Arg Leu His His His Leu Phe Leu Ala Gly Leu Gln Gln Gln Arg 
65                  70                  75                  80  


Ser Val Glu Pro Met Arg Leu Ser Met Asp Thr Pro Met Pro Glu Leu 
                85                  90                  95      


Gln Val Gly Pro Gln Glu Gln Glu Leu Arg Gln Leu Leu His Lys Asp 
            100                 105                 110         


Lys Ser Lys Arg Ser Ala Val Ala Ser Ser Val Val Lys Gln Lys Leu 
        115                 120                 125             


Ala Glu Val Ile Leu Lys Lys Gln Gln Ala Ala Leu Glu Arg Thr Val 
    130                 135                 140                 


His Pro Asn Ser Pro Gly Ile Pro Tyr Arg Thr Leu Glu Pro Leu Glu 
145                 150                 155                 160 


Thr Glu Gly Ala Thr Arg Ser Met Leu Ser Ser Phe Leu Pro Pro Val 
                165                 170                 175     


Pro Ser Leu Pro Ser Asp Pro Pro Glu His Phe Pro Leu Arg Lys Thr 
            180                 185                 190         


Val Ser Glu Pro Asn Leu Lys Leu Arg Tyr Lys Pro Lys Lys Ser Leu 
        195                 200                 205             


Glu Arg Arg Lys Asn Pro Leu Leu Arg Lys Glu Ser Ala Pro Pro Ser 
    210                 215                 220                 


Leu Arg Arg Arg Pro Ala Glu Thr Leu Gly Asp Ser Ser Pro Ser Ser 
225                 230                 235                 240 


Ser Ser Thr Pro Ala Ser Gly Cys Ser Ser Pro Asn Asp Ser Glu His 
                245                 250                 255     


Gly Pro Asn Pro Ile Leu Gly Ser Glu Ala Asp Ser Asp Arg Arg Thr 
            260                 265                 270         


His Pro Thr Leu Gly Pro Arg Gly Pro Ile Leu Gly Ser Pro His Thr 
        275                 280                 285             


Pro Leu Phe Leu Pro His Gly Leu Glu Pro Glu Ala Gly Gly Thr Leu 
    290                 295                 300                 


Pro Ser Arg Leu Gln Pro Ile Leu Leu Leu Asp Pro Ser Gly Ser His 
305                 310                 315                 320 


Ala Pro Leu Leu Thr Val Pro Gly Leu Gly Pro Leu Pro Phe His Phe 
                325                 330                 335     


Ala Gln Ser Leu Met Thr Thr Glu Arg Leu Ser Gly Ser Gly Leu His 
            340                 345                 350         


Trp Pro Leu Ser Arg Thr Arg Ser Glu Pro Leu Pro Pro Ser Ala Thr 
        355                 360                 365             


Ala Pro Pro Pro Pro Gly Pro Met Gln Pro Arg Leu Glu Gln Leu Lys 
    370                 375                 380                 


Thr His Val Gln Val Ile Lys Arg Ser Ala Lys Pro Ser Glu Lys Pro 
385                 390                 395                 400 


Arg Leu Arg Gln Ile Pro Ser Ala Glu Asp Leu Glu Thr Asp Gly Gly 
                405                 410                 415     


Gly Pro Gly Gln Val Val Asp Asp Gly Leu Glu His Arg Glu Leu Gly 
            420                 425                 430         


His Gly Gln Pro Glu Ala Arg Gly Pro Ala Pro Leu Gln Gln His Pro 
        435                 440                 445             


Gln Val Leu Leu Trp Glu Gln Gln Arg Leu Ala Gly Arg Leu Pro Arg 
    450                 455                 460                 


Gly Ser Thr Gly Asp Thr Val Leu Leu Pro Leu Ala Gln Gly Gly His 
465                 470                 475                 480 


Arg Pro Leu Ser Arg Ala Gln Ser Ser Pro Ala Ala Pro Ala Ser Leu 
                485                 490                 495     


Ser Ala Pro Glu Pro Ala Ser Gln Ala Arg Val Leu Ser Ser Ser Glu 
            500                 505                 510         


Thr Pro Ala Arg Thr Leu Pro Phe Thr Thr Gly Leu Ile Tyr Asp Ser 
        515                 520                 525             


Val Met Leu Lys His Gln Cys Ser Cys Gly Asp Asn Ser Arg His Pro 
    530                 535                 540                 


Glu His Ala Gly Arg Ile Gln Ser Ile Trp Ser Arg Leu Gln Glu Arg 
545                 550                 555                 560 


Gly Leu Arg Ser Gln Cys Glu Cys Leu Arg Gly Arg Lys Ala Ser Leu 
                565                 570                 575     


Glu Glu Leu Gln Ser Val His Ser Glu Arg His Val Leu Leu Tyr Gly 
            580                 585                 590         


Thr Asn Pro Leu Ser Arg Leu Lys Leu Asp Asn Gly Lys Leu Ala Gly 
        595                 600                 605             


Leu Leu Ala Gln Arg Met Phe Val Met Leu Pro Cys Gly Gly Val Gly 
    610                 615                 620                 


Val Asp Thr Asp Thr Ile Trp Asn Glu Leu His Ser Ser Asn Ala Ala 
625                 630                 635                 640 


Arg Trp Ala Ala Gly Ser Val Thr Asp Leu Ala Phe Lys Val Ala Ser 
                645                 650                 655     


Arg Glu Leu Lys Asn Gly Phe Ala Val Val Arg Pro Pro Gly His His 
            660                 665                 670         


Ala Asp His Ser Thr Ala Met Gly Phe Cys Phe Phe Asn Ser Val Ala 
        675                 680                 685             


Ile Ala Cys Arg Gln Leu Gln Gln Gln Ser Lys Ala Ser Lys Ile Leu 
    690                 695                 700                 


Ile Val Asp Trp Asp Val His His Gly Asn Gly Thr Gln Gln Thr Phe 
705                 710                 715                 720 


Tyr Gln Asp Pro Ser Val Leu Tyr Ile Ser Leu His Arg His Asp Asp 
                725                 730                 735     


Gly Asn Phe Phe Pro Gly Ser Gly Ala Val Asp Glu Val Gly Ala Gly 
            740                 745                 750         


Ser Gly Glu Gly Phe Asn Val Asn Val Ala Trp Ala Gly Gly Leu Asp 
        755                 760                 765             


Pro Pro Met Gly Asp Pro Glu Tyr Leu Ala Ala Phe Arg Ile Val Val 
    770                 775                 780                 


Met Pro Ile Ala Arg Glu Phe Ser Pro Asp Leu Val Leu Val Ser Ala 
785                 790                 795                 800 


Gly Phe Asp Ala Ala Glu Gly His Pro Ala Pro Leu Gly Gly Tyr His 
                805                 810                 815     


Val Ser Ala Lys Cys Phe Gly Tyr Met Thr Gln Gln Leu Met Asn Leu 
            820                 825                 830         


Ala Gly Gly Ala Val Val Leu Ala Leu Glu Gly Gly His Asp Leu Thr 
        835                 840                 845             


Ala Ile Cys Asp Ala Ser Glu Ala Cys Val Ala Ala Leu Leu Gly Asn 
    850                 855                 860                 


Arg Val Asp Pro Leu Ser Glu Glu Gly Trp Lys Gln Lys Pro Asn Leu 
865                 870                 875                 880 


Asn Ala Ile Arg Ser Leu Glu Ala Val Ile Arg Val His Ser Lys Tyr 
                885                 890                 895     


Trp Gly Cys Met Gln Arg Leu Ala Ser Cys Pro Asp Ser Trp Val Pro 
            900                 905                 910         


Arg Val Pro Gly Ala Asp Lys Glu Glu Val Glu Ala Val Thr Ala Leu 
        915                 920                 925             


Ala Ser Leu Ser Val Gly Ile Leu Ala Glu Asp Arg Pro Ser Glu Gln 
    930                 935                 940                 


Leu Val Glu Glu Glu Glu Pro Met Asn Leu 
945                 950                 

<210>  2940
<211>  1208
<212>  DNA
<213>  Homo sapiens

<400>  2940
gtcacatggt gtgagcattt tgagagtcgt tggtgtccta gacgcacaga aattgaccct     60

cccacccgca atgagcagga ccctcctctg aagacttccc acgggtcaga ctgaaatagt    120

cacttctcca aagctggatt tgtctatcac atggtccagt gtcatcgtgg gcttcttagc    180

tcccggtttg ggggtttcct aggaattctt ttccctcctg ctgccccttg gtagcctctc    240

tgggttcatg acacgtgtgt gagatgctgt acgttaggcc tcatgctttg ctctgagcac    300

ttgagggcct ggtgctgggc cctcgagtcc tgggccaccc agcagtcgtg tccgcatgtg    360

ggaaggccgt ggctctgtgg cagccatgtt ggctggagct gtgttgatgt gttggctgct    420

gccacctggg gaagtgtctg ggcgtgtgtg gacaggtgtg aggggctggg gctggggtag    480

gggcaggatg aaatgcaggc ctgtgtgggt gtgaggggtg tgtacccgcc cggctccatg    540

tgggtgcctg ctgtggcggt gctggcgtgt tctctgcagc caaggccatg gggcgtgagg    600

actccctggg tccccgctct gacccttgct cctgcagggc tgatctatga ctcggtcatg    660

ctgaagcacc agtgctcctg cggtgacaac agcaggcacc cggagcacgc cggccgcatc    720

cagagcatct ggtcccggct gcaggagcgg gggctccgga gccagtgtga gtgtctccga    780

ggccggaagg cctccctgga agagctgcag tcggtccact ctgagcggca cgtgctcctc    840

tacggcacca acccgctcag ccgcctcaaa ctggacaacg ggaagctggc agggctcctg    900

gcacagcgga tgtttgtgat gctgccctgt ggtggggttg gggtggacac tgacaccatc    960

tggaatgagc ttcattcctc caatgcagcc cgctgggccg ctggcagtgt cactgacctc   1020

gccttcaaag tggcttctcg tgagctaaag aatggtttcg ctgtggtgcg gcccccagga   1080

caccatgcag atcattcaac agccatgggc ttctgcttct tcaactcagt ggccatcgcc   1140

tgccggcagc tgcaacagca gagcaaggcc agcaagatcc tcattgtaga ctgggtagtg   1200

atgataag                                                            1208


<210>  2941
<211>  237
<212>  PRT
<213>  Homo sapiens

<400>  2941


Met Gln Ala Cys Val Gly Val Arg Gly Val Tyr Pro Pro Gly Ser Met 
1               5                   10                  15      


Trp Val Pro Ala Val Ala Val Leu Ala Cys Ser Leu Gln Pro Arg Pro 
            20                  25                  30          


Trp Gly Val Arg Thr Pro Trp Val Pro Ala Leu Thr Leu Ala Pro Ala 
        35                  40                  45              


Gly Leu Ile Tyr Asp Ser Val Met Leu Lys His Gln Cys Ser Cys Gly 
    50                  55                  60                  


Asp Asn Ser Arg His Pro Glu His Ala Gly Arg Ile Gln Ser Ile Trp 
65                  70                  75                  80  


Ser Arg Leu Gln Glu Arg Gly Leu Arg Ser Gln Cys Glu Cys Leu Arg 
                85                  90                  95      


Gly Arg Lys Ala Ser Leu Glu Glu Leu Gln Ser Val His Ser Glu Arg 
            100                 105                 110         


His Val Leu Leu Tyr Gly Thr Asn Pro Leu Ser Arg Leu Lys Leu Asp 
        115                 120                 125             


Asn Gly Lys Leu Ala Gly Leu Leu Ala Gln Arg Met Phe Val Met Leu 
    130                 135                 140                 


Pro Cys Gly Gly Val Gly Val Asp Thr Asp Thr Ile Trp Asn Glu Leu 
145                 150                 155                 160 


His Ser Ser Asn Ala Ala Arg Trp Ala Ala Gly Ser Val Thr Asp Leu 
                165                 170                 175     


Ala Phe Lys Val Ala Ser Arg Glu Leu Lys Asn Gly Phe Ala Val Val 
            180                 185                 190         


Arg Pro Pro Gly His His Ala Asp His Ser Thr Ala Met Gly Phe Cys 
        195                 200                 205             


Phe Phe Asn Ser Val Ala Ile Ala Cys Arg Gln Leu Gln Gln Gln Ser 
    210                 215                 220                 


Lys Ala Ser Lys Ile Leu Ile Val Asp Trp Val Val Met 
225                 230                 235         

<210>  2942
<211>  1410
<212>  DNA
<213>  Homo sapiens

<400>  2942
gtcacatggt gtgagcattt tgagagtcgt tggtgtccta gacgcacaga aattgaccct     60

cccacccgca atgagcagga ccctcctctg aagacttccc acgggtcaga ctgaaatagt    120

cacttctcca aagctggatt tgtctatcac atggtccagt gtcatcgtgg gcttcttagc    180

tcccggtttg ggggtttcct aggaattctt ttccctcctg ctgccccttg gtagcctctc    240

tgggttcatg acacgtgtgt gagatgctgt acgttaggcc tcatgctttg ctctgagcac    300

ttgagggcct ggtgctgggc cctcgagtcc tgggccaccc agcagtcgtg tccgcatgtg    360

ggaaggccgt ggctctgtgg cagccatgtt ggctggagct gtgttgatgt gttggctgct    420

gccacctggg gaagtgtctg ggcgtgtgtg gacaggtgtg aggggctggg gctggggtag    480

gggcaggatg aaatgcaggc ctgtgtgggt gtgaggggtg tgtacccgcc cggctccatg    540

tgggtgcctg ctgtggcggt gctggcgtgt tctctgcagc caaggccatg gggcgtgagg    600

actccctggg tccccgctct gacccttgct cctgcagggc tgatctatga ctcggtcatg    660

ctgaagcacc agtgctcctg cggtgacaac agcaggcacc cggagcacgc cggccgcatc    720

cagagcatct ggtcccggct gcaggagcgg gggctccgga gccagtgtga gtgtctccga    780

ggccggaagg cctccctgga agagctgcag tcggtccact ctgagcggca cgtgctcctc    840

tacggcacca acccgctcag ccgcctcaaa ctggacaacg ggaagctggc agggctcctg    900

gcacagcgga tgtttgtgat gctgccctgt ggtggggttg ggcctcttgc gactctctct    960

gccttcctcg cctctcttgg tctgcctcgc cctccccatc tccccatcat gccccccggc   1020

ccctccctag ccttgaggcc cagggactgg gtttgggggg cctcccagcc tgggctaggg   1080

gccctgagtg gaagacagtg gtgcagacgg cccctccagc tccgaccgtc ccgcagggcc   1140

tgagcagagt cagctggggc ttaaaacccc ctcccggccc aaaccccaag tcccgcccag   1200

gtaacgccat gccccctccc ctgaccgggg aggcaggcgt gatgctgcca gcagagtgct   1260

ggccagataa tgggctggtg ctgggactta agctgggaaa aagtcatgct gggattgggg   1320

gacacaggag gccttgcctt tgggcggtgg ggcactgggg aggcagcact gtctgcccag   1380

ctccctgccc ctggggtcct ggccgtgggg                                    1410


<210>  2943
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  2943


Met Gln Ala Cys Val Gly Val Arg Gly Val Tyr Pro Pro Gly Ser Met 
1               5                   10                  15      


Trp Val Pro Ala Val Ala Val Leu Ala Cys Ser Leu Gln Pro Arg Pro 
            20                  25                  30          


Trp Gly Val Arg Thr Pro Trp Val Pro Ala Leu Thr Leu Ala Pro Ala 
        35                  40                  45              


Gly Leu Ile Tyr Asp Ser Val Met Leu Lys His Gln Cys Ser Cys Gly 
    50                  55                  60                  


Asp Asn Ser Arg His Pro Glu His Ala Gly Arg Ile Gln Ser Ile Trp 
65                  70                  75                  80  


Ser Arg Leu Gln Glu Arg Gly Leu Arg Ser Gln Cys Glu Cys Leu Arg 
                85                  90                  95      


Gly Arg Lys Ala Ser Leu Glu Glu Leu Gln Ser Val His Ser Glu Arg 
            100                 105                 110         


His Val Leu Leu Tyr Gly Thr Asn Pro Leu Ser Arg Leu Lys Leu Asp 
        115                 120                 125             


Asn Gly Lys Leu Ala Gly Leu Leu Ala Gln Arg Met Phe Val Met Leu 
    130                 135                 140                 


Pro Cys Gly Gly Val Gly Pro Leu Ala Thr Leu Ser Ala Phe Leu Ala 
145                 150                 155                 160 


Ser Leu Gly Leu Pro Arg Pro Pro His Leu Pro Ile Met Pro Pro Gly 
                165                 170                 175     


Pro Ser Leu Ala Leu Arg Pro Arg Asp Trp Val Trp Gly Ala Ser Gln 
            180                 185                 190         


Pro Gly Leu Gly Ala Leu Ser Gly Arg Gln Trp Cys Arg Arg Pro Leu 
        195                 200                 205             


Gln Leu Arg Pro Ser Arg Arg Ala 
    210                 215     

<210>  2944
<211>  713
<212>  DNA
<213>  Homo sapiens

<400>  2944
aggctgacag tgaccgcagg acccatccga ctctgggccc tcgggggcca atcctgggga     60

gcccccacac tcccctcttc ctgccccatg gcttggagcc cgaggctggg ggcaccttgc    120

cctctcgcct gcagcccatt ctcctcctgg acccctcagg ctctcatgcc ccgctgctga    180

ctggtgagtc tgctgcttct tcagggaagg ggctgggtcc ctgcaccctg ctaagagcca    240

agcttgggat ggacccatcc ttcctcccca tctctgtccc cctgtcctgc gcattgccct    300

gctgcaccct ggccccccac cctataccct cgcttccttc cattgctccc tgtggttccc    360

tccttattcc accccccgat tctttccagt gcccgggctt gggcccttgc ccttccactt    420

tgcccagtcc ttaatgacca ccgagcggct ctctgggtca ggcctccact ggccactgag    480

ccggactcgc tcagagcccc tgccccccag tgccaccgct cccccaccgc cgggccccat    540

gcagccccgc ctggagcagc tcaaaactca cgtccaggtg atcaagaggt cagccaagcc    600

gagtgagaag ccccggctgc ggcagatacc ctcggctgaa gacctggaga cagatggcgg    660

gggaccgggc caggtggtgg acgatggcct ggagcacagg gagctgggcc atg           713


<210>  2945
<211>  92
<212>  PRT
<213>  Homo sapiens

<400>  2945


Met Thr Thr Glu Arg Leu Ser Gly Ser Gly Leu His Trp Pro Leu Ser 
1               5                   10                  15      


Arg Thr Arg Ser Glu Pro Leu Pro Pro Ser Ala Thr Ala Pro Pro Pro 
            20                  25                  30          


Pro Gly Pro Met Gln Pro Arg Leu Glu Gln Leu Lys Thr His Val Gln 
        35                  40                  45              


Val Ile Lys Arg Ser Ala Lys Pro Ser Glu Lys Pro Arg Leu Arg Gln 
    50                  55                  60                  


Ile Pro Ser Ala Glu Asp Leu Glu Thr Asp Gly Gly Gly Pro Gly Gln 
65                  70                  75                  80  


Val Val Asp Asp Gly Leu Glu His Arg Glu Leu Gly 
                85                  90          

<210>  2946
<211>  974
<212>  DNA
<213>  Homo sapiens

<400>  2946
cagggtgcag ctcccccaat gacagcgagc acggccccaa tcccatcctg ggctcggagg     60

taaggccttg ccgagactgg gctctcctgg ggcagttctg aggctcagcc ttcttccagc    120

aggcggccct acctgggctg gggctgcagg gtctgggcag cccctgccag agcctcctgg    180

gtgttctggg gaaggtgcgc cggggtagag gtctgggacc ggtgaccctc gccctgctcc    240

ctatggcagg cgctcttggg ccagcggctg cggctgcagg agacttctgt ggccccgttc    300

gccttgccga cagtgtcctt gctgcccgca atcactctgg ggctgcccgc ccctgccagg    360

gtgagtggct ggggtgccca cccccactcc aagccccccc agcttctttc actccctttt    420

cttgctgcct caccccatca tcttcattgt tctctgctgg aatcttcttc cccgtgactt    480

ctcccgcctc tcccccaggc tgacagtgac cgcaggaccc atccgactct gggccctcgg    540

gggccaatcc tggggagccc ccacactccc ctcttcctgc cccatggctt ggagcccgag    600

gctgggggca ccttgccctc tcgcctgcag cccattctcc tcctggaccc ctcaggctct    660

catgccccgc tgctgactgt gcccgggctt gggcccttgc ccttccactt tgcccagtcc    720

ttaatgacca ccgagcggct ctctgggtca ggcctccact ggccactgag ccggactcgc    780

tcagagcccc tgccccccag tgccaccgct cccccaccgc cgggccccat gcagccccgc    840

ctggagcagc tcaaaactca cgtccaggtg atcaagaggt cagccaagcc gagtgagaag    900

ccccggctgc ggcagatacc ctcggctgaa gacctggaga cagatggcgg gggaccgggc    960

caggtggtgg acga                                                      974


<210>  2947
<211>  82
<212>  PRT
<213>  Homo sapiens

<400>  2947


Met Thr Thr Glu Arg Leu Ser Gly Ser Gly Leu His Trp Pro Leu Ser 
1               5                   10                  15      


Arg Thr Arg Ser Glu Pro Leu Pro Pro Ser Ala Thr Ala Pro Pro Pro 
            20                  25                  30          


Pro Gly Pro Met Gln Pro Arg Leu Glu Gln Leu Lys Thr His Val Gln 
        35                  40                  45              


Val Ile Lys Arg Ser Ala Lys Pro Ser Glu Lys Pro Arg Leu Arg Gln 
    50                  55                  60                  


Ile Pro Ser Ala Glu Asp Leu Glu Thr Asp Gly Gly Gly Pro Gly Gln 
65                  70                  75                  80  


Val Val 
        

<210>  2948
<211>  343
<212>  DNA
<213>  Homo sapiens

<400>  2948
ccctgagaag gtcttggcct gaagacactc acctctcttt ccccaggagt gtcttttagg     60

aagacagaca aatagccagc agttccacag cgactcaggg gactgccagg gttcaaatcc    120

tgctcctgct agatgccact tctgctgctc ttcattgctg ccctagacaa ggccaggccc    180

tgcggcgtgc tgcgagcctt ccttccgtta tctttaccag ctctacatgg tcattcacag    240

atgagaaagc tgaagatcag agagctcaca catttcccac aaggttacac agtcagtaag    300

agacactatc aggattccaa tgacctgctg ttaaagttca tct                      343


<210>  2949
<211>  69
<212>  PRT
<213>  Homo sapiens

<400>  2949


Met Pro Leu Leu Leu Leu Phe Ile Ala Ala Leu Asp Lys Ala Arg Pro 
1               5                   10                  15      


Cys Gly Val Leu Arg Ala Phe Leu Pro Leu Ser Leu Pro Ala Leu His 
            20                  25                  30          


Gly His Ser Gln Met Arg Lys Leu Lys Ile Arg Glu Leu Thr His Phe 
        35                  40                  45              


Pro Gln Gly Tyr Thr Val Ser Lys Arg His Tyr Gln Asp Ser Asn Asp 
    50                  55                  60                  


Leu Leu Leu Lys Phe 
65                  

<210>  2950
<211>  353
<212>  DNA
<213>  Homo sapiens

<400>  2950
gtggagtgat agaaaaatct tccaatgaac tatcaagaag acagacaaat agccagcagt     60

tccacagcga ctcaggggac tgccagggtt caaatcctgc tcctgctaga tgccacttct    120

gctgctcttc attgctgccc tagacaaggc caggccctgc ggcgtgctgc gagccttcct    180

tccgttatct ttaccagctc tacatggtca ttcacagatg agaaagctga agatcagaga    240

gctcacacat ttcccacaag gttacacagt cagtaagaga cactatcagg attccaatga    300

cctgctgtta aagttcatct cttattcact cattgcctcc ctcaaggctg aag           353


<210>  2951
<211>  83
<212>  PRT
<213>  Homo sapiens

<400>  2951


Met Asn Tyr Gln Glu Asp Arg Gln Ile Ala Ser Ser Ser Thr Ala Thr 
1               5                   10                  15      


Gln Gly Thr Ala Arg Val Gln Ile Leu Leu Leu Leu Asp Ala Thr Ser 
            20                  25                  30          


Ala Ala Leu His Cys Cys Pro Arg Gln Gly Gln Ala Leu Arg Arg Ala 
        35                  40                  45              


Ala Ser Leu Pro Ser Val Ile Phe Thr Ser Ser Thr Trp Ser Phe Thr 
    50                  55                  60                  


Asp Glu Lys Ala Glu Asp Gln Arg Ala His Thr Phe Pro Thr Arg Leu 
65                  70                  75                  80  


His Ser Gln 
            

<210>  2952
<211>  589
<212>  DNA
<213>  Homo sapiens

<400>  2952
aaagcccaga aacagactct cctggtacag aggaaacaca actcacaagc agaggtaggg     60

gtatgttcaa cctgatcgtc ctcaaagtaa tgccaattaa aatgagacaa agaagacaga    120

caaatagcca gcagttccac agcgactcag gggactgcca gggttcaaat cctgctcctg    180

ctagatgcca cttctgctgc tcttcattgc tgccctagac aaggccaggc cctgcggcgt    240

gctgcgagcc ttccttccgt tatctttacc agctctacat ggtcattcac agatgagaaa    300

gctgaagatc agagagctca cacatttccc acaaggttac acagtcagta agagacacta    360

tcaggattcc aatgacctgc tgttaaagtt catctcttat tcactcattg cctccctcaa    420

ggctgaagag tggggtggag gggagaccag cagagctact gagctcaatc tgcctccttg    480

gccctcccag cccagagctc tgccagcggt ggtaggagga gtgtggtaag tatttgctga    540

tgaatgaaca accgaaggac aaaataatga actgtcatct tccaaggca                589


<210>  2953
<211>  51
<212>  PRT
<213>  Homo sapiens

<400>  2953


Met Phe Asn Leu Ile Val Leu Lys Val Met Pro Ile Lys Met Arg Gln 
1               5                   10                  15      


Arg Arg Gln Thr Asn Ser Gln Gln Phe His Ser Asp Ser Gly Asp Cys 
            20                  25                  30          


Gln Gly Ser Asn Pro Ala Pro Ala Arg Cys His Phe Cys Cys Ser Ser 
        35                  40                  45              


Leu Leu Pro 
    50      

<210>  2954
<211>  561
<212>  DNA
<213>  Homo sapiens

<400>  2954
aaacacaact cacaagcaga ggtaggggta tgttcaacct gatcgtcctc aaagtaatgc     60

caattaaaat gagacaaagg aaaaagccca ccgtgagggg tgatggccag gtgctcactg    120

cagattccct cccatatatg ggaggctcct ggagctccat agtctcctct actactgctg    180

aggagcaggc catggcaggc gcctgtgggg acagccccca gaggacaggg ctgactgcag    240

gaggaacaga gcatcacagt gagaagacag acaaatagcc agcagttcca cagcgactca    300

ggggactgcc agggttcaaa tcctgctcct gctagatgcc acttctgctg ctcttcattg    360

ctgccctaga caaggccagg ccctgcggcg tgctgcgagc cttccttccg ttatctttac    420

cagctctaca tggtcattca cagatgagaa agctgaagat cagagagctc acacatttcc    480

cacaaggtta cacagtcagt aagagacact atcaggattc caatgacctg ctgttaaagt    540

tcatctctta ttcactcatt g                                              561


<210>  2955
<211>  82
<212>  PRT
<213>  Homo sapiens

<400>  2955


Met Phe Asn Leu Ile Val Leu Lys Val Met Pro Ile Lys Met Arg Gln 
1               5                   10                  15      


Arg Lys Lys Pro Thr Val Arg Gly Asp Gly Gln Val Leu Thr Ala Asp 
            20                  25                  30          


Ser Leu Pro Tyr Met Gly Gly Ser Trp Ser Ser Ile Val Ser Ser Thr 
        35                  40                  45              


Thr Ala Glu Glu Gln Ala Met Ala Gly Ala Cys Gly Asp Ser Pro Gln 
    50                  55                  60                  


Arg Thr Gly Leu Thr Ala Gly Gly Thr Glu His His Ser Glu Lys Thr 
65                  70                  75                  80  


Asp Lys 
        

<210>  2956
<211>  569
<212>  DNA
<213>  Homo sapiens

<400>  2956
acaactcaca agcagaggta ggggtatgtt caacctgatc gtcctcaaag taatgccaat     60

taaaatgaga caaagaagac agacaaatag ccagcagttc cacagcgact caggggactg    120

ccagggttca aatcctgctc ctgctagatg ccacttctgc tgctcttcat tgctgcccta    180

gacaaggcca ggccctgcgg cgtgctgcga gccttccttc cgttatcttt accagctcta    240

catggtcatt cacagatgag aaagctgaag atcagagagc tcacacattt cccacaaggt    300

tacacagtca gtaagagaca ctatcaggat tccaatgacc tgctgttaaa gttcatctct    360

tattcactca ttgcctccct caaggctgaa gagtggggtg gaggggagac cagcagagct    420

actgagctca atctgcctcc ttggccctcc cagcccagag ctctgccagc ggtggtagga    480

ggagtgtgtt ctggtagata tcatggagca ggagtcccta gcaccaagaa gctgagatcc    540

ggaagaggcg ccccaaaaaa tcagcctgg                                      569


<210>  2957
<211>  139
<212>  PRT
<213>  Homo sapiens

<400>  2957


Met Pro Leu Leu Leu Leu Phe Ile Ala Ala Leu Asp Lys Ala Arg Pro 
1               5                   10                  15      


Cys Gly Val Leu Arg Ala Phe Leu Pro Leu Ser Leu Pro Ala Leu His 
            20                  25                  30          


Gly His Ser Gln Met Arg Lys Leu Lys Ile Arg Glu Leu Thr His Phe 
        35                  40                  45              


Pro Gln Gly Tyr Thr Val Ser Lys Arg His Tyr Gln Asp Ser Asn Asp 
    50                  55                  60                  


Leu Leu Leu Lys Phe Ile Ser Tyr Ser Leu Ile Ala Ser Leu Lys Ala 
65                  70                  75                  80  


Glu Glu Trp Gly Gly Gly Glu Thr Ser Arg Ala Thr Glu Leu Asn Leu 
                85                  90                  95      


Pro Pro Trp Pro Ser Gln Pro Arg Ala Leu Pro Ala Val Val Gly Gly 
            100                 105                 110         


Val Cys Ser Gly Arg Tyr His Gly Ala Gly Val Pro Ser Thr Lys Lys 
        115                 120                 125             


Leu Arg Ser Gly Arg Gly Ala Pro Lys Asn Gln 
    130                 135                 

<210>  2958
<211>  9626
<212>  DNA
<213>  Homo sapiens

<400>  2958
tacgggaaat gtttggtgca gcatccagaa tggacaccac tgctgtctgc accgggggag     60

tgacagagag tcgagggatt gtggatagcc tgcagaagtt ttcctcgctc cctgcttacc    120

tccccacgaa cttgcacatc tccaatgcag aggagtcctt tttccttaaa gaagccaacc    180

aagacctcac aaggaactcc agtctgcagg cccgggtgga gccattcttc atctaccgag    240

ccaggacacc ccctattatc aatgccagct atggcccatt ttcagtggag aagataatcc    300

cccaggagct cctgttgaca tctacagcct ttggaaacat ggacaaattt cccttcaact    360

ggaaattgaa atcccacatc cttgacagct ccatctactc caacagaccc aaagtgcaga    420

ccttgtttta tgtcactggc atgggctggg atgacagtga ccttacggaa gatctaccct    480

gtgtcaagat gtttgctttc cctgaggcca gggaagtggc agccagctgt cggctgcaag    540

gggccccagg gctgtgtgtg gctgagctgg agctgctgcc cgagtggttc agctcaggcc    600

tggacctgga accagaggag gagatcccag ccctgctcgg gggcaccacg atggagctct    660

tcttcacgct ctacccagct gacaaggctg gccagtgtcc tctggaggag gaaggcaagt    720

gggagaacaa tatccactcg ggcctggaga gcccccagca agcgtttcca gcccgagaga    780

ggattgggag tgtggtggtc tacccaaccc aagatgatct gaagtggtcc ctggtgagct    840

tggacgagaa tgtggtcatc tcggtacctc tgaatctagt ccgggaaggg gacacggcca    900

cctttttggt ctctctgacc agtagctctg tggcagacca gttcactctt agaattaagg    960

cggcagcagg tgtgaagata acggcagtga gagtcagcag tgaggaccaa tgggcagtcc   1020

aggaggaaat tgataatggc agcactcaga cgtcggccac cctcacctgc atgggccatc   1080

gcccggacac gcagagcagg gtaaatggat ccttctatga gatcttgcaa gtggactttg   1140

gaattgataa tagcagtgac ctggctgggg cccagcagat tacctggcag gtggagtacc   1200

cgattgagga ctccatgagt gagctggtcg tctccgagat cttcgtcagc cagacaacct   1260

tcgtgggcat cgtccctctt gccatggaca ccgaggtttt gaacactgcc attctcactg   1320

gaaagcctgt ttcagttcct gtcaaagtcg tgggggtcca ggaggatggt tctgtggtcg   1380

atgtgtctga gtctgtggaa tgcaagtctg ccgatgaaga tgtcattaag gtttccaaca   1440

actgtgattc catttttgtg aatgggaagg aaatgaagag caaagtggac acgattgtga   1500

acttcaccca ccagcacttc acctcccagt tcgaggtcac tgtctgggca cccaggctcc   1560

ccctgcagat tgagatctca gacaccgagc tgagccagat caagggctgg aggatcccgg   1620

ttgctgccaa cagaaggcct acccgggaaa gcgatgacga ggacgatgag gagaagaagg   1680

gacgaggctg ctccctgcag taccagcacg ccacagtgcg tgtcctcacc cagtttgtgg   1740

ccgagtcacc tgacttaggg cagctgacct acatgctggg ccccgactgg cagtttgaca   1800

tcactgacct tgtgaccgag ttcatgaagg tggaggagcc gaaaatcgct cagttacagg   1860

acggcaggac cctggctggt cgggagccgg gaataaccac ggtgcaggtc ctctcgccgt   1920

tgtctgactc catcctggct gagaagacgg tgattgtcct ggatgaccga gtcaccatcg   1980

cggagctggg agtgcagctc gtagctggca tgtctctctc cctgcagcca caccgagcag   2040

acaaaagggc catcgtctcc acagctgctg ccctggatgt tcttcagtcc ccacagcagg   2100

aagcaatagt aagttcttgg attttgttca gtgatggttc ggtgacacct ttagacattt   2160

acgatcctaa ggattattct gttactgtct catcattgga tgaaatggtg gtgtctgtcc   2220

aggcaaacct tgagtccaaa tggccaattg tggttgcaga gggtgaagga caagggcctt   2280

tgattaagtt agaaatgatg ataagtgaac cttgtcagaa gaccaagagg aagagtgttc   2340

ttgccgtggg taaaggaaat gtcaaggtca aattcgaacc aagtagtgat gagcaccaag   2400

gaggcagcaa tgatattgag ggcataaatc gggaatataa agaccacctc agtaattcca   2460

tagagcgcga aggaaaccag gagagagcag tccaggaatg gttccaccgt ggcacacctg   2520

ttggccaaga ggaaagtacc aacaaaagca caacccccca gtctcccatg gaagggaaga   2580

ataagttact caaaagtggt ggtccagatg cctttacaag cttccccact caagggaagt   2640

caccggaccc caataatcct agtgacctca cagtgacctc aagggggcta acggacttgg   2700

agattggcat gtatgccttg ctctgcgtct tctgtctggc cattctggtc ttcttgatca   2760

actgcgtggc gtttgcctgg aaatacagac acaaaaggtt tgctgtgagt gagcagggca   2820

acatccccca ttcccacgac tgggtctggc ttgggaatga agtggaactt ttggagaacc   2880

ctgttgacat tacactccca tcagaggagt gcacaaccat gatagacagg ggcctgcagt   2940

tcgaggagag gaacttcctt ctgaatggca gttcccagaa gacttttcat agtcaactac   3000

tcagaccctc tgactatgtc tatgagaaag aaattaaaaa tgaacctatg aattcttcgg   3060

gcccaaagag gaagagagtc aagttcactt cctacaccac catcctccca gaggacggcg   3120

gcccatacac caactccatc ctgtttgaca gcgatgataa catcaagtgg gtctgccaag   3180

atatggggct gggggattca caggacttta gagactatat ggaaagtctg caagaccaga   3240

tgtaaactcc tttcttatgt ttgtattcac ctttatgcct tctgtttttt gaatgctgga   3300

gcagtgagtt tgatcagcaa taggggatga tttaacaaag tttgatttgt ggaggtctgg   3360

tgggattcat ttctaagcag gtaaaagagg tttggagagc tatagaagct gggttttaag   3420

tttggaaatg cctctaaaac agccacatgt ggggactgga gaaattctaa gacaacagtt   3480

ttatggactg cctggtacga gctcagtgca aatgtattaa acctgacccc acagacattg   3540

ttagtcatct cgtgacaaat ggccatgtgg aattagaaaa gatttgggtg ttgatttttc   3600

tatttctaga ccttttaaag cacagtggac acttattgcc ccttggcctg agtttagaca   3660

tacatgaaag atgactgaat gtagctatcc tgatttgtca tgagcgctgc tcattatttt   3720

tatatacatt tgcacctgca cctgttcctt tgacctctgg aattcttttt gaaacatgaa   3780

gagaagaaat ttcagtcttt tccttgagct ctgtttgatt tacacatgag ttttcttccc   3840

tgggatttgc catgccatgt tatttcctgg gtctccatgc aggatgtcag gtttttccag   3900

ttttctgcac ttcatcatct agggatggta tccaagaagc ttattctcac tttgtttttt   3960

ccttcctttt gttgttgaac tttcttgtat aacactggga caaagggttt tacttaaaat   4020

gttaatatac agtgagggag ggccatctct ttactgtttt ctatgtgaag tttcaaacat   4080

ttggaaaaaa gttgtcaatc acaaacattt atttttattc tctgcttgtt gaaaactcat   4140

ggggaactcc tggagtgcat ttctgagggt aaaaaggccc caacatagct gtatttatac   4200

aagtgctttg tggccaacac aatttactat ccaaactgaa gtcttaaagt agaattgacc   4260

tacacagaaa ggaaattgcc taggcaatag atgcagatta cactttccat tttaccagaa   4320

caaaagtttt ttttttttta aataagtaga atgacagttc aagttagcaa tatatagaaa   4380

tccatccata caatgaccaa aataaataaa taaataaaac tcaatcatga ctttggcaga   4440

gataaaacat tgacaagggt gtgcatttgt ggagagaagc agtgggtttc cccccaaaat   4500

ccatacaaat aaatgactat tccagaactc aagaagcagc tattatagaa aaaaaaatta   4560

aaaaccacag ctattgaaaa attaaaacgg caagagaaaa aaagaaacaa ctcctgcata   4620

atgtttaaat aaaaatgtta ttttaatagc atcatgaatg gtcttaaggc aaaaatttca   4680

gattagcaaa atgtgatgac atatttatta agattgtatt attggaaatg tagacactgg   4740

actagtatgc ctcattatga gctttactga gccatttgca tctctaagaa atatgatttt   4800

aaaggcccaa agtaggaagg atctgcaggg ggtcacctga agcagtgccc tgactccaaa   4860

tggctgataa ctgagctaat ccaaggagag gcgttcagtt gttctcttat tatagatttc   4920

cttgggtggg aacatgacaa ccccgcctcc tctagccatg acgtggcagc caaaaagttc   4980

ttcctgtatc tctggcccac aggactgtag tgtgtttggg aacagtgctg aaattgcaag   5040

tgatgtaggc ctgacctcca gagcccagcg ttcagttagt tgtataaaat ggggcttagg   5100

aaccgaagct gatgaagttc caaaagtagt tcagtttgat gggataagga agcaaggaga   5160

gccaggcatt agctgcaaaa ggagcttgca gagagatggc tgacacttta tgggaagatt   5220

cctcagtcag ccaaaagctt ttcaaagagt ttggtgcaga ggtagctcag agccaaccat   5280

ccaggaccga agaaagctca tgtgctgatt gacacatagc tatccaggtg agtcggctcc   5340

ttctatgagg cttttcaatc gtctctccct ttggatctct ggcattccag aaagactggg   5400

aattcatttc tgaaaatgat gaacctccgc tgaaacgggg aggaaatctc ttacacacat   5460

acagcagggt cctgcccact ggtaaagtga gacgttgggt agggggtgta actggggagg   5520

aggtgaagga aattatccct gccatgggga gtgttattca ggaacataaa aattagagca   5580

ttccctctga tggcagtgct tgacggggtg cagggaacaa actggggagc gttcaaacat   5640

gccagtggtt tctcagcagg gctggaaact ggccacagtc ctgaagatgc ttcttgtgac   5700

aacttagagt cactgggagt cacacagctc ctgtgtagcc gcctttgctc ctctgtgtta   5760

aaacccagtc agttcaaaat aacaatcaaa tggaaggcca tgggggaagg gttccttcca   5820

ccatataacc cacacccaga tgtatataaa cgcatataca tacatatacc cgtgtgtgtg   5880

tgtgtgtgtg tgtgtgtgtg tgtgaatact gaagagccag acaacaaact atttagtaag   5940

aatcaacagt gactgtcaat tgttctcaga tttggcatgg atactatttc tcatgaaata   6000

atgtcattaa agtatttcct cctctaaata tttcctgaag atcataaacc atgggttata   6060

gcaccttgtt ttccagctag tcaatataca actattaggt gctgtgcccc aaaatatcta   6120

aaatgggggt aaagatataa actattaagc catgaaatct aattttctgg ggaccatgca   6180

tttgcctgga ttttccagga ttttatggct gatagaccca aattattagt cttgataaac   6240

aacctgaacc aaacatttat aaagtccctt cctctcccat gggaatggaa tgctcagact   6300

cctgctgagg gagacaccag caagcctctt gagaaggcac cagacagtga actctgtggt   6360

cacatgaagg gaggttcaga tgctagacga ccagcgtatg acctggaacc attgaggatt   6420

gcaaccgctg cctccagggt ccagatgtgc tgcagtagag ggcagagcac aggaatcaag   6480

aagcagctgc cacaccaaag aactgatgct taaacacaca ggtgtgttgc atttgagaga   6540

aggcaagaag aaaagacaat agaaggttac cctggaaaaa caacacctag caaacctcag   6600

aatactccat gtgtcccaag agaaggaata attgtctttc tagctgttat atattgcaca   6660

ctggccagga taaattccca gactataata atcctgacta tgtagacgga agtttctatt   6720

tataaagtca tgcaggggga aagttgatta atttttgtcc cattgccaca tctgtagact   6780

aagtaatttt taacttgcta acttttagaa tgtccacctt tgtgcatttt ggtagcattc   6840

ttgtttcatt attttagaaa ggggtcttcc cattactggg atgtcggggc cctgtcagag   6900

aactattatt aaggctctgt gagggaactg ttcagtctca cagcaaggac cacagagcgt   6960

ggtttcatct gaaccctaca agtcagggac accagtgtgt tttctactcg agttacctaa   7020

aaatggtctc aattttccat ttcattctct gtaaatgaca caatagatgg tttatagact   7080

cagcagccct caccttttat taaaattata tatgtgtgat gtaatgcata tcacctgtca   7140

tgtaaaggga cggtatggat ggtggaaaag ttatgctaaa atatggattg cagatatttt   7200

tgtatgtaat ataggcaata taatgaaaca ccgagttttt taaagtgaaa gcatgcaaaa   7260

tcgtagcttt taaatgtaca gacatcccac tcaaaaatat ctaaactgat agtgggaaaa   7320

acatttgaga cctagtaaca tcatgaaatg cactgaattt ggaattctgg cctagaaagg   7380

ctgtggctta tgttgggatt gatgatggaa tctgccagaa cattttcatc ttattcttct   7440

tgacttttgg atttttttct tttctttttt tctggaaata tttcggaaat aaagtgactt   7500

catttttcag cataaaagta tattctaacc acagggtaac acatcgtttt taacatgaaa   7560

ataaacattt aaacattctt cagttgtttc attattttat ctgcatgttc cataaagcag   7620

ctgtatggtt ggctataata tagatttatt ttttcttttc agccagagat tttaataccc   7680

ttgatgcagt aataaatgga catcaaaaga aaacatttct taaaagttgc caacgtattt   7740

taccttgaaa acatttctta tttgttatcc tagtaggctg gggaaagctt ctctccagat   7800

gtctcagaaa aagatctcct gtttctcatg gccccgtcca gggtcaaacc atgttgaaag   7860

tcagtgctga aatgcatgat gctgcgggtg tttgagagcc tttgacctct gtccaccctt   7920

tggtctttgc tcgtcaatgg cttggtcttg tatatgtatc tggggcaggg gctttgtact   7980

gggcccaggg tgctgagctt tccagaacag gcagagctct agagacctaa gaaaaccaca   8040

ggacaggcgg ggattctttt tgagaggctg aagtagatgt ttcagctgaa agatgggtgg   8100

tacacttgcc aagtgcctag aggggctaga ggctctctgt tggtgtgtgt gtatttcttg   8160

aaactgcaga gtcatttttg gcatgctggc aaatgctact ccttgctttt aggatgaata   8220

gggatgcctc tttggcgata atttgacgtg tcataataaa tgcccaatac caaacctagt   8280

ctttctccag gcccttcaga catcattcag gtaactgggt gtaaacacag gagttggctt   8340

tgtgaaactg aggcaggatt tcctgcctct aaactattgg cagcaaaaga gccaaaaatg   8400

tgctcccagg tgcaaaaccc cagccccatc agaattgctt ctcagcactt tgggtaactg   8460

ttttgcacta acagcttcct ccttgtcttt tccctgggaa catgggagca ctgacacaga   8520

actcaactgg tccagccctt tgggaggccc aggtgggcag atcacctgaa gtcaggagtt   8580

tgagaccagc ctgggcaaca tggtgaaacc ctgtctctac taaaaataca aaaattatcc   8640

agtcgtggtg gtgcatgcct gtagtcccag ctactctgga ggctgaggca ggagaatcac   8700

ttgaacctga gaggtgaagg ttgtagtgag ccaagatcgt accactgcac tctggcctgg   8760

gcaacaagag cgagactttg tctcaaacag aaacaaaaca agaaaaacaa aaagaactta   8820

accagttctc cccagatctc agcgtgcatg catatataga gtttagtaaa atgtgtttca   8880

aaaaaagaag gataaaagaa agtttgaagt aagatttgta aaagaatgaa cactttaggt   8940

tttgtgtgtg agtgcaaaat gtaaacacgg catttgaaat tttttggtat tgaaatcctt   9000

aatgcctgtt agtttcttta tggttttata caattgagat aggttctgaa gtttttttgt   9060

tgtttgcttt tagaaatttt taaaaataca aaaaaaaagc gcagaaacat tttcatctgg   9120

gttactgtgt ttatagacta ttctatgact caagacaact aggacaccat cattttccag   9180

ataagaaata acagttcaag ttcattaggg aaattatctt cccagtccaa gcaagcaata   9240

atgttatcaa cttacaatat tggacaatct tcatattcta tgagatgcct ttaaaatttc   9300

tttggattta atgctgctct tggtcagttg ttcaaatgaa acattgtaat ttcatgttaa   9360

cgacaagagt ctcacgggag tctctttaga tgctgcagga actgagagga tagaagacct   9420

ctctatacat ctacattgcc cattggagta aagcacttta cagagagatg gatgccgctt   9480

tgggatttgg ggtctatgta atgctgattt ttttcaaacc tgtttggaaa tattacttct   9540

ttgggatggc tgaaataact tttgacctga cacatctttc tgtacttcct gtggccaaaa   9600

aagcaagtga gactttctgt ttccca                                        9626


<210>  2959
<211>  1078
<212>  PRT
<213>  Homo sapiens

<400>  2959


Met Phe Gly Ala Ala Ser Arg Met Asp Thr Thr Ala Val Cys Thr Gly 
1               5                   10                  15      


Gly Val Thr Glu Ser Arg Gly Ile Val Asp Ser Leu Gln Lys Phe Ser 
            20                  25                  30          


Ser Leu Pro Ala Tyr Leu Pro Thr Asn Leu His Ile Ser Asn Ala Glu 
        35                  40                  45              


Glu Ser Phe Phe Leu Lys Glu Ala Asn Gln Asp Leu Thr Arg Asn Ser 
    50                  55                  60                  


Ser Leu Gln Ala Arg Val Glu Pro Phe Phe Ile Tyr Arg Ala Arg Thr 
65                  70                  75                  80  


Pro Pro Ile Ile Asn Ala Ser Tyr Gly Pro Phe Ser Val Glu Lys Ile 
                85                  90                  95      


Ile Pro Gln Glu Leu Leu Leu Thr Ser Thr Ala Phe Gly Asn Met Asp 
            100                 105                 110         


Lys Phe Pro Phe Asn Trp Lys Leu Lys Ser His Ile Leu Asp Ser Ser 
        115                 120                 125             


Ile Tyr Ser Asn Arg Pro Lys Val Gln Thr Leu Phe Tyr Val Thr Gly 
    130                 135                 140                 


Met Gly Trp Asp Asp Ser Asp Leu Thr Glu Asp Leu Pro Cys Val Lys 
145                 150                 155                 160 


Met Phe Ala Phe Pro Glu Ala Arg Glu Val Ala Ala Ser Cys Arg Leu 
                165                 170                 175     


Gln Gly Ala Pro Gly Leu Cys Val Ala Glu Leu Glu Leu Leu Pro Glu 
            180                 185                 190         


Trp Phe Ser Ser Gly Leu Asp Leu Glu Pro Glu Glu Glu Ile Pro Ala 
        195                 200                 205             


Leu Leu Gly Gly Thr Thr Met Glu Leu Phe Phe Thr Leu Tyr Pro Ala 
    210                 215                 220                 


Asp Lys Ala Gly Gln Cys Pro Leu Glu Glu Glu Gly Lys Trp Glu Asn 
225                 230                 235                 240 


Asn Ile His Ser Gly Leu Glu Ser Pro Gln Gln Ala Phe Pro Ala Arg 
                245                 250                 255     


Glu Arg Ile Gly Ser Val Val Val Tyr Pro Thr Gln Asp Asp Leu Lys 
            260                 265                 270         


Trp Ser Leu Val Ser Leu Asp Glu Asn Val Val Ile Ser Val Pro Leu 
        275                 280                 285             


Asn Leu Val Arg Glu Gly Asp Thr Ala Thr Phe Leu Val Ser Leu Thr 
    290                 295                 300                 


Ser Ser Ser Val Ala Asp Gln Phe Thr Leu Arg Ile Lys Ala Ala Ala 
305                 310                 315                 320 


Gly Val Lys Ile Thr Ala Val Arg Val Ser Ser Glu Asp Gln Trp Ala 
                325                 330                 335     


Val Gln Glu Glu Ile Asp Asn Gly Ser Thr Gln Thr Ser Ala Thr Leu 
            340                 345                 350         


Thr Cys Met Gly His Arg Pro Asp Thr Gln Ser Arg Val Asn Gly Ser 
        355                 360                 365             


Phe Tyr Glu Ile Leu Gln Val Asp Phe Gly Ile Asp Asn Ser Ser Asp 
    370                 375                 380                 


Leu Ala Gly Ala Gln Gln Ile Thr Trp Gln Val Glu Tyr Pro Ile Glu 
385                 390                 395                 400 


Asp Ser Met Ser Glu Leu Val Val Ser Glu Ile Phe Val Ser Gln Thr 
                405                 410                 415     


Thr Phe Val Gly Ile Val Pro Leu Ala Met Asp Thr Glu Val Leu Asn 
            420                 425                 430         


Thr Ala Ile Leu Thr Gly Lys Pro Val Ser Val Pro Val Lys Val Val 
        435                 440                 445             


Gly Val Gln Glu Asp Gly Ser Val Val Asp Val Ser Glu Ser Val Glu 
    450                 455                 460                 


Cys Lys Ser Ala Asp Glu Asp Val Ile Lys Val Ser Asn Asn Cys Asp 
465                 470                 475                 480 


Ser Ile Phe Val Asn Gly Lys Glu Met Lys Ser Lys Val Asp Thr Ile 
                485                 490                 495     


Val Asn Phe Thr His Gln His Phe Thr Ser Gln Phe Glu Val Thr Val 
            500                 505                 510         


Trp Ala Pro Arg Leu Pro Leu Gln Ile Glu Ile Ser Asp Thr Glu Leu 
        515                 520                 525             


Ser Gln Ile Lys Gly Trp Arg Ile Pro Val Ala Ala Asn Arg Arg Pro 
    530                 535                 540                 


Thr Arg Glu Ser Asp Asp Glu Asp Asp Glu Glu Lys Lys Gly Arg Gly 
545                 550                 555                 560 


Cys Ser Leu Gln Tyr Gln His Ala Thr Val Arg Val Leu Thr Gln Phe 
                565                 570                 575     


Val Ala Glu Ser Pro Asp Leu Gly Gln Leu Thr Tyr Met Leu Gly Pro 
            580                 585                 590         


Asp Trp Gln Phe Asp Ile Thr Asp Leu Val Thr Glu Phe Met Lys Val 
        595                 600                 605             


Glu Glu Pro Lys Ile Ala Gln Leu Gln Asp Gly Arg Thr Leu Ala Gly 
    610                 615                 620                 


Arg Glu Pro Gly Ile Thr Thr Val Gln Val Leu Ser Pro Leu Ser Asp 
625                 630                 635                 640 


Ser Ile Leu Ala Glu Lys Thr Val Ile Val Leu Asp Asp Arg Val Thr 
                645                 650                 655     


Ile Ala Glu Leu Gly Val Gln Leu Val Ala Gly Met Ser Leu Ser Leu 
            660                 665                 670         


Gln Pro His Arg Ala Asp Lys Arg Ala Ile Val Ser Thr Ala Ala Ala 
        675                 680                 685             


Leu Asp Val Leu Gln Ser Pro Gln Gln Glu Ala Ile Val Ser Ser Trp 
    690                 695                 700                 


Ile Leu Phe Ser Asp Gly Ser Val Thr Pro Leu Asp Ile Tyr Asp Pro 
705                 710                 715                 720 


Lys Asp Tyr Ser Val Thr Val Ser Ser Leu Asp Glu Met Val Val Ser 
                725                 730                 735     


Val Gln Ala Asn Leu Glu Ser Lys Trp Pro Ile Val Val Ala Glu Gly 
            740                 745                 750         


Glu Gly Gln Gly Pro Leu Ile Lys Leu Glu Met Met Ile Ser Glu Pro 
        755                 760                 765             


Cys Gln Lys Thr Lys Arg Lys Ser Val Leu Ala Val Gly Lys Gly Asn 
    770                 775                 780                 


Val Lys Val Lys Phe Glu Pro Ser Ser Asp Glu His Gln Gly Gly Ser 
785                 790                 795                 800 


Asn Asp Ile Glu Gly Ile Asn Arg Glu Tyr Lys Asp His Leu Ser Asn 
                805                 810                 815     


Ser Ile Glu Arg Glu Gly Asn Gln Glu Arg Ala Val Gln Glu Trp Phe 
            820                 825                 830         


His Arg Gly Thr Pro Val Gly Gln Glu Glu Ser Thr Asn Lys Ser Thr 
        835                 840                 845             


Thr Pro Gln Ser Pro Met Glu Gly Lys Asn Lys Leu Leu Lys Ser Gly 
    850                 855                 860                 


Gly Pro Asp Ala Phe Thr Ser Phe Pro Thr Gln Gly Lys Ser Pro Asp 
865                 870                 875                 880 


Pro Asn Asn Pro Ser Asp Leu Thr Val Thr Ser Arg Gly Leu Thr Asp 
                885                 890                 895     


Leu Glu Ile Gly Met Tyr Ala Leu Leu Cys Val Phe Cys Leu Ala Ile 
            900                 905                 910         


Leu Val Phe Leu Ile Asn Cys Val Ala Phe Ala Trp Lys Tyr Arg His 
        915                 920                 925             


Lys Arg Phe Ala Val Ser Glu Gln Gly Asn Ile Pro His Ser His Asp 
    930                 935                 940                 


Trp Val Trp Leu Gly Asn Glu Val Glu Leu Leu Glu Asn Pro Val Asp 
945                 950                 955                 960 


Ile Thr Leu Pro Ser Glu Glu Cys Thr Thr Met Ile Asp Arg Gly Leu 
                965                 970                 975     


Gln Phe Glu Glu Arg Asn Phe Leu Leu Asn Gly Ser Ser Gln Lys Thr 
            980                 985                 990         


Phe His Ser Gln Leu Leu Arg Pro  Ser Asp Tyr Val Tyr  Glu Lys Glu 
        995                 1000                 1005             


Ile Lys  Asn Glu Pro Met Asn  Ser Ser Gly Pro Lys  Arg Lys Arg 
    1010                 1015                 1020             


Val Lys  Phe Thr Ser Tyr Thr  Thr Ile Leu Pro Glu  Asp Gly Gly 
    1025                 1030                 1035             


Pro Tyr  Thr Asn Ser Ile Leu  Phe Asp Ser Asp Asp  Asn Ile Lys 
    1040                 1045                 1050             


Trp Val  Cys Gln Asp Met Gly  Leu Gly Asp Ser Gln  Asp Phe Arg 
    1055                 1060                 1065             


Asp Tyr  Met Glu Ser Leu Gln  Asp Gln Met 
    1070                 1075             

<210>  2960
<211>  2632
<212>  DNA
<213>  Homo sapiens

<400>  2960
gggaatacca ggggtgggca ctgtcaagag acccagcttt gacttcaaat gccacccaga     60

gggacaactg ctcactttca gagcaggagc aggaggccag aggagagtgt gagtctaaca    120

tctgcacagt gagaagtcca ggagaagcaa aaatgagatc caggctggag cggctgtgcc    180

agagggtccc tatgatccag acctcaagag agggttcctg gacctcccac agaaagggat    240

tcaagaccag ctgaaactga ttagagccaa gatagccaac caaatgactt caggaagacc    300

tcaggcttca ttatcatctc atttccatgc taaaaaaacc cagctcccta gaacaatggg    360

aaatattggg cacttcatca ggcgagttca ggtgcatttc tagagattgt ccaggtgctg    420

gtaacaataa tagagaacca tccatatcca caagaggcag aacctcttcc agcaaaatgg    480

tgctgcctca cccaaaggtc acactggcat tagcccctca tcctctggag ttcatctcat    540

ccaggcgaag acagctggct ggcctcagag ggtgagacgc aactcgaggg taaaaacatt    600

tttacagggc atggacacaa aagtggcctt tacctctgga taagctttta aaacttccca    660

tttacatgta aaggtgtact ttctatgtgc caccaagaaa cctaaagtga gtaaaaggtg    720

tttcacttta atcaagttcc ccaatgaggg ggcacagctc tgaaaagcac tgtcacaaca    780

ggagattcga gggtgcatgc aaagcaatgt ttctagaaaa tgccaaagga aacagacaca    840

actccagtgt ggactcccgc ttccctgcac tgctgctcca tcctcagggc ggaggccaca    900

tcgtccagct agctgtgaga acctcatcat gctccttgat tgtgtgcagc aggtgtctgc    960

tgaagtcctc cacactctgc ctggccagat tctcttcttg caggattcct ttgactaaac   1020

tgtcaccttg tcaaagaggt ctgatgccga ctaaaagttc tctgttactg ggcgtgcaga   1080

gagaagccta ttgtggctgt aaggatgggt gaaggagaag ggcacaaagt ggacagcaga   1140

agcaggagct gtcacacagg cctggcccat catggtggag agtttggatt tcattctaag   1200

ccaaatggga agtctcatcc gctgagcagt gcctcctccc gattcagcac gtccctggtg   1260

ccgactttct gcacgtgttc actttgaggc tgcattgtgg gcctgcaaga aatgcaaagc   1320

tggttgaggc tttattcaat tcaaattcaa gctgttaaat cgaggctctc agactcctgc   1380

tgcctggcca gtggagaaat taactttcac atatggcttt gggatttctc tctgtcatcc   1440

tggtcgacgt gttctctcat ttttctgaag tctgggacct caacacagac atctgggtga   1500

aggccttgac agcagcgctg gtgcaaaatg aattgtcaca tcacacccaa cgttctcaac   1560

ctttagaatc tgaaagtaag aaaaacacct caaacaaaac attaaagatt gaataattga   1620

aggcactatg cttggtgctg aagaaggtct aaggaggtct acaccacaga ggctgcaccc   1680

actcctcagc cttgctgagc cacaccattc tcatctctac agcatccacc tctcttggct   1740

cttgtaagga ttgagacatg ccaccaggct tactattgat tctgagtaat cagcacagat   1800

ttctaaaaga aactttatgg gatgctgaga catgaataaa aacaacttta ttcctttgga   1860

aaggacaacc cacatgctaa gaagatgaca ctacacgttg ttatagcccg aaaggccctc   1920

tttccacagg ggagcagtga aaagtagagg ttgcccatgt ggattcccaa gtcagataga   1980

tgtggattca gatcccagct ctgctgcttg ctacccaaga gaccatggac tgtggactct   2040

ttaggtctca gggtttttgt ttgttgtctg tttttcactt ccaaaaccag aaaatgagaa   2100

gatattttcc ataagatggc ggtggagaag agaacttgat ggaccttgct tggacaaaat   2160

gccttcaccg ctaactcagt cagctatggc gatgggtcaa ggacctggtg gttttacaga   2220

gaagaccctt ggtcaaatct ttgtgaatga agcaaccatt ctgatgttca ataacaggaa   2280

tgcaccagtt tataccaaac tatctgtact attgagaaca gcaaaaatat ctgaccaaaa   2340

acaccaaaga gtgacatttt aaaagacatc aaagaactct caaggcttcc agagttggaa   2400

agatcaagaa agagagaatg caacttcatt aagtgactca actccaaata ggagcatttc   2460

aagagtatgt atttcaacaa agaagtatta gaagatgaca gtgtccttgc agtatctttt   2520

aggggctatc agaacatgat ttctgctata ttctatcatc ggagccttaa taatgttaac   2580

tataattcaa gggaagatca aataaacttc acctttcaag gaaaggagta ac           2632


<210>  2961
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  2961


Met Arg Gly His Ser Ser Glu Lys His Cys His Asn Arg Arg Phe Glu 
1               5                   10                  15      


Gly Ala Cys Lys Ala Met Phe Leu Glu Asn Ala Lys Gly Asn Arg His 
            20                  25                  30          


Asn Ser Ser Val Asp Ser Arg Phe Pro Ala Leu Leu Leu His Pro Gln 
        35                  40                  45              


Gly Gly Gly His Ile Val Gln Leu Ala Val Arg Thr Ser Ser Cys Ser 
    50                  55                  60                  


Leu Ile Val Cys Ser Arg Cys Leu Leu Lys Ser Ser Thr Leu Cys Leu 
65                  70                  75                  80  


Ala Arg Phe Ser Ser Cys Arg Ile Pro Leu Thr Lys Leu Ser Pro Cys 
                85                  90                  95      


Gln Arg Gly Leu Met Pro Thr Lys Ser Ser Leu Leu Leu Gly Val Gln 
            100                 105                 110         


Arg Glu Ala Tyr Cys Gly Cys Lys Asp Gly 
        115                 120         

<210>  2962
<211>  2452
<212>  DNA
<213>  Homo sapiens

<400>  2962
gggaatacca ggggtgggca ctgtcaagag acccagcttt gacttcaaat gccacccaga     60

gggacaactg ctcactttca gagcaggagc aggaggccag aggagagtgg gtccctatga    120

tccagacctc aagagagggt tcctggacct cccacagaaa gggattcaag accagctgaa    180

actgattaga gccaagatag ccaaccaaat gacttcagga agacctcagg cttcattatc    240

atctcatttc catgctaaaa aaacccagct ccctagaaca atgggaaata ttgggcactt    300

catcaggcga gttcaggtgc atttctagag attgtccagg tgctggtaac aataatagag    360

aaccatccat atccacaaga ggcagaacct cttccagcaa aatggtgctg cctcacccaa    420

aggtggccga ggaggccgtc ggaggaccac aaagctgcaa gtggctttcc tgcggcctgc    480

agggaacagg tggaggacac ttggaagggc acccaccccg ggtctcacag gagtctgcac    540

ccgcaggtca cactggcatt agcccctcat cctctggagt tcatctcatc caggcgaaga    600

cagctggctg gcctcagagg gtgagacgca actcgagggt aaaaacattt ttacagggca    660

tggacacaaa agtggccttt acctctggat aagcttttaa aacttcccat ttacatgtaa    720

aggtgtactt tctatgtgcc accaagaaac ctaaagtgag taaaaggtgt ttcactttaa    780

tcaagttccc caatgagggg gcacagctct gaaaagcact gtcacaacag gagattcgag    840

ggtgcatgca aagcaatgtt tctagaaaat gccaaaggaa acagacacaa ctccagtgtg    900

gactcccgct tccctgcact gctgctccat cctcagggcg gaggccacat cgtccagcta    960

gctgtgagaa cctcatcatg ctccttgatt gtgtgcagca ggtgtctgct gaagtcctcc   1020

acactctgcc tgtctcatcc gctgagcagt gcctcctccc gattcagcac gtccctggtg   1080

ccgactttct gcacgtgttc actttgaggc tgcattgtgg gcctgcaaga aatgcaaagc   1140

tggttgaggc tttattcaat tcaaattcaa gctgttaaat cgaggctctc agactcctgc   1200

tgcctggcca gtggagaaat taactttcac atatggcttt gggatttctc tctgtcatcc   1260

tggtcgacgt gttctctcat ttttctgaag tctgggacct caacacagac atctgggtga   1320

aggccttgac agcagcgctg gtgcaaaatg aattgtcaca tcacacccaa cgttctcaac   1380

ctttagaatc tgaaagtaag aaaaacacct caaacaaaac attaaagatt gaataattga   1440

aggcactatg cttggtgctg aagaaggtct aaggaggtct acaccacaga ggctgcaccc   1500

actcctcagc cttgctgagc cacaccattc tcatctctac agcatccacc tctcttggct   1560

cttgtaagga ttgagacatg ccaccaggct tactattgat tctgagtaat cagcacagat   1620

ttctaaaaga aactttatgg gatgctgaga catgaataaa aacaacttta ttcctttgga   1680

aaggacaacc cacatgctaa gaagatgaca ctacacgttg ttatagcccg aaaggccctc   1740

tttccacagg ggagcagtga aaagtagagg ttgcccatgt ggattcccaa gtcagataga   1800

tgtggattca gatcccagct ctgctgcttg ctacccaaga gaccatggac tgtggactct   1860

ttaggtctca gggtttttgt ttgttgtctg tttttcactt ccaaaaccag aaaatgagaa   1920

gatattttcc ataagatggc ggtggagaag agaacttgat ggaccttgct tggacaaaat   1980

gccttcaccg ctaactcagt cagctatggc gatgggtcaa ggacctggtg gttttacaga   2040

gaagaccctt ggtcaaatct ttgtgaatga agcaaccatt ctgatgttca ataacaggaa   2100

tgcaccagtt tataccaaac tatctgtact attgagaaca gcaaaaatat ctgaccaaaa   2160

acaccaaaga gtgacatttt aaaagacatc aaagaactct caaggcttcc agagttggaa   2220

agatcaagaa agagagaatg caacttcatt aagtgactca actccaaata ggagcatttc   2280

aagagtatgt atttcaacaa agaagtatta gaagatgaca gtgtccttgc agtatctttt   2340

aggggctatc agaacatgat ttctgctata ttctatcatc ggagccttaa taatgttaac   2400

tataattcaa gggaagatca aataaacttc acctttcaag gaaaggagta ac           2452


<210>  2963
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  2963


Met Leu Lys Lys Pro Ser Ser Leu Glu Gln Trp Glu Ile Leu Gly Thr 
1               5                   10                  15      


Ser Ser Gly Glu Phe Arg Cys Ile Ser Arg Asp Cys Pro Gly Ala Gly 
            20                  25                  30          


Asn Asn Asn Arg Glu Pro Ser Ile Ser Thr Arg Gly Arg Thr Ser Ser 
        35                  40                  45              


Ser Lys Met Val Leu Pro His Pro Lys Val Ala Glu Glu Ala Val Gly 
    50                  55                  60                  


Gly Pro Gln Ser Cys Lys Trp Leu Ser Cys Gly Leu Gln Gly Thr Gly 
65                  70                  75                  80  


Gly Gly His Leu Glu Gly His Pro Pro Arg Val Ser Gln Glu Ser Ala 
                85                  90                  95      


Pro Ala Gly His Thr Gly Ile Ser Pro Ser Ser Ser Gly Val His Leu 
            100                 105                 110         


Ile Gln Ala Lys Thr Ala Gly Trp Pro Gln Arg Val Arg Arg Asn Ser 
        115                 120                 125             


Arg Val Lys Thr Phe Leu Gln Gly Met Asp Thr Lys Val Ala Phe Thr 
    130                 135                 140                 


Ser Gly 
145     

<210>  2964
<211>  547
<212>  DNA
<213>  Homo sapiens

<400>  2964
tacagccttc atctctaaca tgttccaaag ttgcatctct ttttcgatag aaataaaaca     60

acagtgatga aagcgtcaaa ggaatccttc aaaatggctt gatgtgttgg gattgaaaac    120

ctgccacttg aggttgcaac ccaggtgacc ctaatttcct gccaagttga gtacaagatc    180

ttcttttagc attggaagta tcagtttttg ggacttccta ctataggatt tataccagtg    240

gcccagttct cagtccgctg gacttaaacg gagagtaaca ccctgccctg cttctcaggc    300

cttcagactc agactaaatc ttaccactga tttcctggtt tttcagcttg cagatgacgc    360

gtctaggatt tctcaacctc tataattgca ctgctgcaac ctgaaacaag aagtatttca    420

ggaaaatcca atcccctctt ggaggacaat gaagatcttt ccacaaaatt tagtcaataa    480

atatttactg agttctcact gtgttcttgg cataatcatc actggaaaat aaaacacaca    540

gaaaatg                                                              547


<210>  2965
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  2965


Asp Phe Ser Thr Ser Ile Ile Ala Leu Leu Gln Pro Glu Thr Arg Ser 
1               5                   10                  15      


Ile Ser Gly Lys Ser Asn Pro Leu Leu Glu Asp Asn Glu Asp Leu Ser 
            20                  25                  30          


Thr Lys Phe Ser Gln 
        35          

<210>  2966
<211>  586
<212>  DNA
<213>  Homo sapiens

<400>  2966
gtggcggtcg ccgggcagca gagcccgggc gcagcgagcg cagcgcagcg cagggagcgc     60

aggcggtggc ggcaccaggt tcccggggct ccagcgctcg gcgcagcgaa gtagcctccg    120

gcggtggcaa ctacggcggc ggcgccgggg cgatgctgtg ggtctcgttg ggcgccggtg    180

tcctggcctc ttcctcagat gaaaagattc tgaagaatag agatcttgaa catagcatgg    240

tgccagacac ataacagaac gaagaacaaa ctaaattcat ctcaaaatga ttataaatca    300

tcaagaagga gtagcctgcc acctggaggc ctgtgtgcgc ttcatccagc cggacgggct    360

ggtgcggggg gcctccaagc tggtgcccgt gggctacggt atctggaagc tgcagattca    420

gcgtgtggtg gaggacaagg tggggacaga cttgctggag gaggagatca ccaagtttga    480

agagtgtatg cagagtgtcg acatcgcagc tttcaacaag atctggcctg agtgtgtgtg    540

tgtgcccgcg tgcatgaggc cctgacacaa ttaaaaactg agaccg                   586


<210>  2967
<211>  92
<212>  PRT
<213>  Homo sapiens

<400>  2967


Met Ile Ile Asn His Gln Glu Gly Val Ala Cys His Leu Glu Ala Cys 
1               5                   10                  15      


Val Arg Phe Ile Gln Pro Asp Gly Leu Val Arg Gly Ala Ser Lys Leu 
            20                  25                  30          


Val Pro Val Gly Tyr Gly Ile Trp Lys Leu Gln Ile Gln Arg Val Val 
        35                  40                  45              


Glu Asp Lys Val Gly Thr Asp Leu Leu Glu Glu Glu Ile Thr Lys Phe 
    50                  55                  60                  


Glu Glu Cys Met Gln Ser Val Asp Ile Ala Ala Phe Asn Lys Ile Trp 
65                  70                  75                  80  


Pro Glu Cys Val Cys Val Pro Ala Cys Met Arg Pro 
                85                  90          

<210>  2968
<211>  833
<212>  DNA
<213>  Homo sapiens

<400>  2968
gcagcgagcg cagcgcagcg cagggagcgc aggcggtggc ggcaccaggt tcccggggct     60

ccagcgctcg gcgcagcgaa gtagcctccg gcggtggcaa ctacggcggc ggcgccgggg    120

cgatgctgtg ggtctcgttg ggcgccggtg tcctggcctc ttcctcagaa cgaagaacaa    180

actaaattca tctcaaaatg attataaatc atcaagaagg agtagcctgc cacctgaact    240

actcatagga aatgacatta gaggaagact tcaaagaaac attaagaact tggatcccat    300

tcacctgagg cacccgaaga agagaccatc catatttcca ggacggaaac acaccctttc    360

cttaggcgtc ctgcgtcccc cgattcctgc tccctggttg ccgcgtcctt ggctggcgtc    420

agaaaaatgg ctacaaactt tctagtaggt gagaagatct ggttccacaa gttcaaatat    480

ggcgatgcag aaaggagatt ctacgaacag atgaacgggc ctgtggccgg cgcctccctc    540

caggaggcca gcatgatcct ccatgatatt gccagagcca gagagaacat cccgaaatcc    600

ctggccggaa gcttaggccc aggggcgtct agcggcccca gcggagacca cagcgagctc    660

gtcgtccgga tcgccagtct ggaagtggac aaccagagag acctggctga acgtgctgga    720

gaagagcttg cccggccact gggccacagc cccgcagacc cagcacatgt ctcccatgcg    780

ccaagtggag cccccggcca agaagctagc cacaccagca gaggatgacg agg           833


<210>  2969
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  2969


Met Ala Thr Asn Phe Leu Val Gly Glu Lys Ile Trp Phe His Lys Phe 
1               5                   10                  15      


Lys Tyr Gly Asp Ala Glu Arg Arg Phe Tyr Glu Gln Met Asn Gly Pro 
            20                  25                  30          


Val Ala Gly Ala Ser Leu Gln Glu Ala Ser Met Ile Leu His Asp Ile 
        35                  40                  45              


Ala Arg Ala Arg Glu Asn Ile Pro Lys Ser Leu Ala Gly Ser Leu Gly 
    50                  55                  60                  


Pro Gly Ala Ser Ser Gly Pro Ser Gly Asp His Ser Glu Leu Val Val 
65                  70                  75                  80  


Arg Ile Ala Ser Leu Glu Val Asp Asn Gln Arg Asp Leu Ala Glu Arg 
                85                  90                  95      


Ala Gly Glu Glu Leu Ala Arg Pro Leu Gly His Ser Pro Ala Asp Pro 
            100                 105                 110         


Ala His Val Ser His Ala Pro Ser Gly Ala Pro Gly Gln Glu Ala Ser 
        115                 120                 125             


His Thr Ser Arg Gly 
    130             

<210>  2970
<211>  575
<212>  DNA
<213>  Homo sapiens

<400>  2970
agcgcagcgc agggagcgca ggcggtggcg gcaccaggtt cccggggctc cagcgctcgg     60

cgcagcgaag tagcctccgg cggtggcaac tacggcggcg gcgccggggc gatgctgtgg    120

gtctcgttgg gcgccggtgt cctggcctct tcctcagaac gaagaacaaa ctaaattcat    180

ctcaaaatga ttataaatca tcaagaagga gtagcctgcc acctgaacta ctcataggaa    240

atgacattag aggaagactt caaagaaaca ttaagaactt ggatcccatt cacctgaggc    300

acccgaagaa gagaccatcc atatttccag atggagtttc attcttatca ctcaggctgg    360

agtgcaatga cgcgatctgg gcttactgca acctccgcct tctgggttca agtgattctc    420

ctgcctctgc ctcccaagta gctgggatta caggtgcacg ccaccacacc cagatcaagc    480

ttcaaaaagt gcatggtggt tatgctgttg aagaacttag acaagaaaat aactcacttg    540

gcagtgagca cagtggagaa tcaaagaatc aatga                               575


<210>  2971
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  2971


Met Glu Phe His Ser Tyr His Ser Gly Trp Ser Ala Met Thr Arg Ser 
1               5                   10                  15      


Gly Leu Thr Ala Thr Ser Ala Phe Trp Val Gln Val Ile Leu Leu Pro 
            20                  25                  30          


Leu Pro Pro Lys 
        35      

<210>  2972
<211>  1309
<212>  DNA
<213>  Homo sapiens

<400>  2972
ggcgcagcga agtagcctcc ggcggtggca actacggcgg cggcgccggg gcgatgctgt     60

gggtctcgtt gggcgccggt gtcctggcct cttcctcaga tgaaaagatt ctgaagaata    120

gagatcttga acatagcatg gtgccagaca cataacagaa cgaagaacaa actaaattca    180

tctcaaaatg attataaatc atcaagaagg agtagcctgc cacctgaact actcatagga    240

aatgacatta gaggaagact tcaaagaaac attaagaact tggatcccat tcacctgagg    300

cacccgaaga agagaccatc catatttcca ggacggaaac acaccctttc cttaggcgtc    360

ctgcgtcccc cgattcctgc tccctggttg ccgcgtcctt ggctggcgtc agaaaaatgg    420

ctacaaactt tctagtaggt gagaagatct ggttccacaa gttcaaatat ggcgatgcag    480

aaaggagatt ctacgaacag atgaacgggc ctgtggccgg cgcctccctc caggaggcca    540

gcatgatcct ccatgatatt gccagagcca gagagaacat cccgaaatcc ctggccggaa    600

gcttaggccc aggggcgtct agcggcccca gcggagacca cagcgagctc gtcgtccgga    660

tcgccagtct ggaagtggac aaccagagag acctggctga acgtgctgga gaagagcttg    720

cccggccact gggccacagc cccgcagacc cagcacatgt ctcccatgcg ccaagtggag    780

cccccggcca agaagctagc cacaccagca gaggatgacg aggacgatga cattgacctg    840

tttggcagcg acaatgaggc aacacagctg cggcattacc aatgaggagc ggctgcagca    900

gtacgcggag aagaaggcca agaagcccgc gctggtggcc aagtcctcca tcctgctgga    960

cttcaagcct tgggacgatg agacggacac ggcccacctg gaggcctgtg tgcgcttcat   1020

ccagccggac gggctggtgc ggggggcctc caagctggtg cccgtgggct acggtatctg   1080

gaagctgcag attcagcgtg tggtggagga caaggtgggg acagacttgc tggaggagga   1140

gatcaccaag tttgaagagt gtatgcagag tgtcgacatc gcagctttca acaagatctg   1200

gcctgagtgt gtgtgtgtgc ccgcgtgcat gaggccctga cacaattaaa aactgagacc   1260

ggcaaaaaaa aaaaaaaaaa aaagggacga aaacaaactt aatgaagct               1309


<210>  2973
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  2973


Met Leu Trp Val Ser Leu Gly Ala Gly Val Leu Ala Ser Ser Ser Asp 
1               5                   10                  15      


Glu Lys Ile Leu Lys Asn Arg Asp Leu Glu His Ser Met Val Pro Asp 
            20                  25                  30          


Thr 
    

<210>  2974
<211>  1332
<212>  DNA
<213>  Homo sapiens

<400>  2974
aaagcatgag aacatcagag tctggggcgg cggcggtggc tgcaacggtg gctgtgacgg     60

tggctgccgc tgggtttggc tttctggatt tttgttcaga gtcgctaatg tatcccccac    120

aatggcagtt gatgacagca atttatattc cagaacgaag aacaaactaa attcatctca    180

aaatgattat aaatcatcaa gaaggagtag cctgccacct gaactactca taggaaatga    240

cattagagga agacttcaaa gaaacattaa gaacttggat cccattcacc tgaggcaccc    300

gaagaagaga ccatccatat ttccagatca agcttcaaaa agtgcatggt ggttatgctg    360

ttgaagaact tagacaagaa aataactcac ttggcagtga gcacagtgga gaatcaaaga    420

atcaatgaat tgtggatctg aaagaaatag agaacatcaa attcagtgca ctcattttac    480

agatgaaaaa ctgtagacct acaaagacag ttgacatgga gggtcttctg attcccgtaa    540

tgttctatag catcatcctt catgagatca tcacagaaac ctagtttaag aacctctggg    600

tcatttttgt atgcatgaaa agtgagaaga aaatgatacc cacaccttcc tgtgggtcca    660

gaggccagca atccatgcat caacctgtgt ttattaaata cccacatgcc ctctgctgtg    720

caccagatat tggtgggcag ggctggtgtg tgaattaaaa aatacacgtc agtcagactt    780

ggtgagacac ttactcacag gtgagcctta gcctagtgca cagcatcaag acctcaactg    840

gttttatttt gcagtccatc cttaagagag aaaaagtctt tctttgatga aaatagccat    900

taggtgcaaa agaggagatt ttagttcaag gtattatagc tctagctgaa ggaaacacac    960

aggaaatgtg attctcctca gagatgtgat ccaggagaaa accaggatcc taaacattcc   1020

tttttgagga atatgtctca ggaaatattc cttttgaaag gtaagggtct accaaatggt   1080

caccatcctc acagacagat ttgttacaac tcccatttca caatgaggaa actgaggcgt   1140

atggaaaaca atctgttaaa agttaagaga acaaatttga aactgggtga aaaattgcaa   1200

cttcttagct ttaagttctc ctttaccaaa tattctctga agtttattcc attctcatgt   1260

taaaaaaaat tgtaaccaaa agcagcatta ctactatgta tcttagtagt tgaacaataa   1320

agtgcatcat tt                                                       1332


<210>  2975
<211>  80
<212>  PRT
<213>  Homo sapiens

<400>  2975


Met Ala Val Asp Asp Ser Asn Leu Tyr Ser Arg Thr Lys Asn Lys Leu 
1               5                   10                  15      


Asn Ser Ser Gln Asn Asp Tyr Lys Ser Ser Arg Arg Ser Ser Leu Pro 
            20                  25                  30          


Pro Glu Leu Leu Ile Gly Asn Asp Ile Arg Gly Arg Leu Gln Arg Asn 
        35                  40                  45              


Ile Lys Asn Leu Asp Pro Ile His Leu Arg His Pro Lys Lys Arg Pro 
    50                  55                  60                  


Ser Ile Phe Pro Asp Gln Ala Ser Lys Ser Ala Trp Trp Leu Cys Cys 
65                  70                  75                  80  

<210>  2976
<211>  3286
<212>  DNA
<213>  Homo sapiens

<400>  2976
caacaataga atgttagtgt gagttatttg gctgagggtc ctaagagacc aggccttaag     60

agtctaggcc tctgtagcaa acaggcagcc tgttttctag ttccttctga aagaactcca    120

gcagctgagt tcatagcagt gggcctagct tggtttaagg aagcaaaagg gagagagaga    180

agtggtcctg acacacatca tgcccacagg catatcagat taaaatgaac atctcaccct    240

gcacctggaa aaaagggggg ctcaggcacc atgtgtgatg ggttgttcat tcagcactct    300

taaaccaaca agttgggatg tttaatcagc tagttcttat actatcatgc tgattttaca    360

attatctgtt gtgaaaagca aggaaccatc tgcttggagg aaacaggcag ctccaggtac    420

ttccttgttg cttagtcaga ggacaagtgt gatgaggact gttcacgacc aagaggaaaa    480

gagagccctg gccaggactc acatagcagg aacaccagca tgtaggctaa cattgcttct    540

cgtttttaag tcaaagttct attccaaaca caagtttttt ttttctcaaa tccacaatct    600

aaaaaactta cttaaaatta ttttattttt ataattaaat ggattttgag catttctaaa    660

gttagactgc tgtatttgtt ttctttctgc atgtaggttt ttattggaaa cataaggtag    720

tcataggaac aatggtggct agatgctttc tgaccttcct gcgggtaaac agcctctgtc    780

aaggaactgt agagatgggg gtctggtctg ggttccctcc tcagagcctc ctcatcacag    840

cacagtgaag gcactctgtg attaggcgtg tctccttaag tgttatgttc tctgttagaa    900

ttctgtcatt ctggaagcct gcagacaggt gtgtttgatg acgtttcagt ggggccttca    960

ggagacatgc agaacttatg gtcagggcat ccataaacat gtgctatgaa gagagtgcct   1020

cctgagattg tattcagtgg ccttaggttg caaatgggct cagtggttac agtttgtgag   1080

gacaggaaca gtgtcttcct acaccgtggt attccccaca acacttacca cagggttagg   1140

tgcttaagag ctggtgaagt catcaggcaa ggtggaagac agacgatgtg caagaagtgt   1200

gtcacagcca ctcagctggc cacacccctg cccatctggt cacgcagctt ccttaaatag   1260

ctgcttctca ggcaggcctt gctcaaggcc agagtcaagg gagcctcaga gacaagagtt   1320

tgaacacttc ctctcatgag aggacttcag cccagggatt tcacaaagtc agtatctgct   1380

tcacaattgg tttcatgttc tgatccccca tcttactaaa catgtaatct gggacaagcc   1440

actggctctc tcagaacctg tttcttcatc tgtgaaatgg gaatgcaaac accagtttca   1500

ccagctgtct taaacccaaa tgagataatg cataactaca aaatgataca caaatgaggt   1560

tgactgtact attcttattc cttgatggca ttaaaggttt tttttttcat aattagtact   1620

ttttctttga atgtgtgagt ggtagatgca attggaaccc ttttgcaact cttcttggtt   1680

ggaaagttat ctaaagttgc taatcagacc ctctgctaat gtaaattcta tatactgaga   1740

cactgctaaa cacccattaa ttttaacttt ctcattaaaa aggatgacat agaaaccctt   1800

ctttgtagtc aatatagatg tattttctca aagtgaatca ttaaacttaa gggctttgtc   1860

atgtgaggcc tctgaaaatt gtacaatatt agaaacatca atgtctgtgt ttaataaact   1920

tactggtagc tttactgtgt tgaatgtctc cacctaattt tgtttgttta aaaccttgct   1980

tttggaaatt tagcccttca acttttcttt aacaaaatct tggaatgaac ttctgattta   2040

aaaaaaaaaa aaaaagctta tatataatgt tgtacatgag ctcaccactt gaaagtaatt   2100

tacttaaata atgagattaa attttaaaac ctttgagtgt caacacattt ttatttaaaa   2160

tttgatatat atggcctttc ctgtttaaaa atactgatta acaaaaactg agatagcctg   2220

tttacttttt atttatttac aataaataaa tacaataaat aaaatttatt tatttattgg   2280

acaagtttac tgaggatgga gtttttggtt ttgttttgct tcgttttcta aaaaaggacg   2340

gaaacacacc ctttccttag gcgtcctgcg tcccccgatt cctgctccct ggttgccgcg   2400

tccttggctg gcgtcagaaa aatggctaca aactttctag taggtgagaa gatctggttc   2460

cacaagttca aatatggcga tgcagaaagg agattctacg aacagatgaa cgggcctgtg   2520

gccggcgcct ccctccagga ggccagcatg atcctccatg atattgccag agccagagag   2580

aacatcccga aatccctggc cggaagctta ggcccagggg cgtctagcgg ccccagcgga   2640

gaccacagcg agctcgtcgt ccggatcgcc agtctggaag tggacaacca gagagacctg   2700

gctgaacgtg ctggagaaga gcttgcccgg ccactgggcc acagccccgc agacccagca   2760

catgtctccc atgcgccaag tggagccccc ggccaagaag ctagccacac cagcagagga   2820

tgacgaggac gatgacattg acctgtttgg cagcgacaat gaggcaacac agctgcggca   2880

ttaccaatga ggagcggctg cagcagtacg cggagaagaa ggccaagaag cccgcgctgg   2940

tggccaagtc ctccatcctg ctggacttca agccttggga cgatgagacg gacacggccc   3000

acctggaggc ctgtgtgcgc ttcatccagc cggacgggct ggtgcggggg gcctccaagc   3060

tggtgcccgt gggctacggt atctggaagc tgcagattca gcgtgtggtg gaggacaagg   3120

tggggacaga cttgctggag gaggagatca ccaagtttga agagtgtatg cagagtgtcg   3180

acatcgcagc tttcaacaag atctggcctg agtgtgtgtg tgtgcccgcg tgcatgaggc   3240

cctgacacaa ttaaaaactg agaccggcaa aaaaaaaaaa aaaaaa                  3286


<210>  2977
<211>  141
<212>  PRT
<213>  Homo sapiens

<400>  2977


Met Thr Arg Thr Met Thr Leu Thr Cys Leu Ala Ala Thr Met Arg Gln 
1               5                   10                  15      


His Ser Cys Gly Ile Thr Asn Glu Glu Arg Leu Gln Gln Tyr Ala Glu 
            20                  25                  30          


Lys Lys Ala Lys Lys Pro Ala Leu Val Ala Lys Ser Ser Ile Leu Leu 
        35                  40                  45              


Asp Phe Lys Pro Trp Asp Asp Glu Thr Asp Thr Ala His Leu Glu Ala 
    50                  55                  60                  


Cys Val Arg Phe Ile Gln Pro Asp Gly Leu Val Arg Gly Ala Ser Lys 
65                  70                  75                  80  


Leu Val Pro Val Gly Tyr Gly Ile Trp Lys Leu Gln Ile Gln Arg Val 
                85                  90                  95      


Val Glu Asp Lys Val Gly Thr Asp Leu Leu Glu Glu Glu Ile Thr Lys 
            100                 105                 110         


Phe Glu Glu Cys Met Gln Ser Val Asp Ile Ala Ala Phe Asn Lys Ile 
        115                 120                 125             


Trp Pro Glu Cys Val Cys Val Pro Ala Cys Met Arg Pro 
    130                 135                 140     

<210>  2978
<211>  4938
<212>  DNA
<213>  Homo sapiens

<400>  2978
gggggatggt gcctgcgatc cccaaaaccc caaagggcgt tttttacagt gctcttttag     60

ctctgctgac cgcggatggc ttaagtgtta acagctcagt gggccctttg ccttttctca    120

tgagtcggct gccctgtgcc agcaagggca aagggccagt gtaacagcct tttgtatctg    180

cactcgtggc tcctgagctc ctgttcggca cacaggaaaa atgaggtcgc accaacaaac    240

tgaaggatgg taaatgttga ggattttatt gccaatgaaa gcggctgtca ctgggagctg    300

aaaaggtaat ggaaagctga aaagcggata aggtgggtag gtacctgaag tctggccatc    360

tacggcagct ggattcttct ccaaagttat actgtcaagc tgtccctctg aagccaagcc    420

acttctcttt gacatccagc cgtagtctct gctcctctcc aactgagtat gagggagatg    480

tttcctatta tccttgataa tgtgccatga acatatgaaa aaacatagaa acatgaagaa    540

aacaagaaga caaaaatcac taacatctgg ttggctgtat agaaacaaag ctgattctgg    600

ttggagtgca gtggtaagat cacagctcac tgctgccttg acttcctggg ctcaagtgat    660

tctcctgcct cagtctcctc agtagctcgg actacagctt gcaaatggat cttacagacg    720

ttgtcacaga gacaagaaaa gcatataaaa aaataaataa agatgagctc ctttcaaggt    780

gactgactag aagcagctgg tgtgtgctgc tctcacaaag agaagaaaga gtggtgagtg    840

gaccatccag gtggacacat tgggattcat caaggaaaca atacacagaa aacagaagaa    900

tgagacagga caatcattca cccagaagtg gcatagagcc gggagatggc cctcaccatg    960

gttagtaagt gagagtcccc agggagtcac atttctgcca cagacctttg caaccctggg   1020

cccaggcgat cccccatgac acccgtgccc caccagggcc tctggactga catagacagc   1080

tacatggagt gtgggcagaa ctgccactca ggcactcatg aaatccttgg agcttttcat   1140

ccccaggcac cctggtacca atggctgcag ctgcggcaat gggggaggac aggctctctt   1200

gcatgtcctc agaataggaa cacaatccat ggggctaagc agtgggtgga ctgtggggct   1260

cttctacaca gcccgttgcc agactggcct gggatcctag catggtcaca aaagtcccac   1320

ctgggctctt gaggaacaga tctgtacttc cctggcatgg aactcctgga ggggatgggc   1380

aggctgctgt ttttgctgct ccacagccct cactcctgtt gccctcagtc ttgggagtga   1440

gcacagtgat tggggactaa catagacccc cagcacagtg tacagacttg cagaaaagca   1500

gccagactct tttccacatg ggtcctcacc cctgctactc ttcactgggc agcacctctt   1560

gaccttggcc cccagcacaa ccaacccgcc cccacatgaa cgctttgtca gtgatggctc   1620

tgtgtttctc tgaggagaaa aatccaaaag acaatccata agccttctgc tattgcagct   1680

gcagtggtat ggcccttact accttcaggc tggggaaaga acgaaggact tggtccttac   1740

actggcccct ccagcacacc atcgccacca tatggagaag agcccagtct ctcttccccg   1800

taagccccca ctcaccactg ttcaccaggc aaggccccta gttggggaca gcagagcagc   1860

tgtcctaccc ccggatgaga attcccactg ctattggctc tatattttcc tgaggtgggc   1920

ctcccagaag caattgacat cccctctgtc actgtcatgg cagcagttct gcccttactg   1980

cactcagact ggggaaagaa caaacagcct gaggtcttca ctcacactcc tagcacaaca   2040

cagtcatgat atggagagga gcccagttgt tcctcctggt gagcccttga cctcctactt   2100

ttcatcaagt gaagcctcca gcttgggcta gcagcgtagc caccccaccc actggctgaa   2160

cattctcagt agcaatggct tgcgtttctc tgaagtaggg ctcccaggga caacggaaag   2220

cacctctccc actgccactg cagcggtact gccttgctgc ccttggactg gggaaggggc   2280

agagaccttg agtgcttaac ccacatgtcc aggaagtgac agctgcccta aggagaggag   2340

gccagtctgt ctcctctgtg agacccctgc cacccttgcg catcaccagg cagggcctcc   2400

aggcatgggt tcacaatgta gctgccccaa tcccaagccc atctctccaa ttagtagtgg   2460

ctctgcattt ctctagggtg gagccccaag agacaagtga aaggccctct gccacagcaa   2520

ctgccaaggt cccttcccct gttgccttca agctggggag ggaaaataaa gccttagctc   2580

gcccctagca gcagtgtgca gcccaggagt gccaaggcca gaccttaagc cagcactgga   2640

gtgggaaagg gagcccacac tttcagagca ctgagaggga gcatggctgc aatcatgaag   2700

aaatacagag gagccacgtg gtggagcaag agcccaccta ctggccatta cacttcagtg   2760

ccatctactg gatcatagcc caaactccaa ctccaaaaat gcttgctaat atacccccct   2820

ctgtgaaaac aacgacaaga tttcaacaac aaagaccctg cacaaaacct cggccctcaa   2880

aaaacattca aaaaaggagt ctgcactcaa ttacaccaca gttaaaggag catcagccca   2940

cacagatgag aaaaaactgg tgcaagagct ctaacaacta aactacagtg ttttctttcc   3000

tccaaataac tgtactagtt cccaaggaag ggttcttaac caggcagaaa gggtggaaat   3060

gacagagaga gaattcaaaa tatggatagg aataaaggtc atcaagattc aggagaaagt   3120

caaaacccaa tccaaggaat ctaacaatta caataaaaca atacaggagt tgaaagacaa   3180

aatggccatt ataagaaaga accaaactga tctgatagag ctaaaaaaca cactaaagaa   3240

ttccttaatg taattgcaag tattaacagc agaatagacc aagctgaaga aagaatctca   3300

gagctcacag gcaacatctc tgaactcagt cagacaaaaa taagaataaa gaagaatgaa   3360

caaaacctcc gagaaatatg ggattatgta gagaccaaat ctatgactca ctggcatcct   3420

tgaaagagag gaggagaaag caagcaactt ggaaaacata tttcaggata tcatctatga   3480

agacttcccc aacatcgcta tggagaacaa cattcaaaat caggaaatgc agaaaatccc   3540

tgtgagattc tatataagaa gaccatccac gagccacatg gtcgtcagat tcttcaaggc   3600

caaaacaaaa gaaaaaatgt taaaggaagc tagagagaag aggcagatca cctacaaagg   3660

aaacctcatt aggctaacag cagatcattc agcagaaatc ccacaagcca gaagagatta   3720

ggagtgtgta ttcagcatta ttaaggaaaa gaaatttcaa ccaagaatct catatctagc   3780

caaacttagt ttcattagcg aaggagaaat aagatcctat tcagacaagc aaatgctaag   3840

ggaattcagt accaccagac atgctctata agagatcctg aagcaagtgc caaatataga   3900

acagaaagac tgttactgac cactgcaaaa gcacactaaa aacgtagacc attgacactg   3960

taaagcaacc acacaaataa agctgcataa taaccagcta acagcacaat gacaggatca   4020

aatcagcaaa taccaatatt aaccttgaaa gtgaaggggc taagtgcccc aatgaaaagt   4080

cacagagtgg caagttggat aaagagcaag accctggcca ggcaggtgac tcatgcctgt   4140

aatctcagca ctttgggaag ctgacacagg tgaatcaaga attcaagacc agtctggcca   4200

acatggtgaa accccatctc tattaaaata caaaaattag ccctggacat ggtggtgctc   4260

atctatagtc ccaggtacta gggaggctga ggcgggcgga tcagttgaac ccaggaggca   4320

gaggttgcag tgagctgaga tcatgccact gcgcttcagc ctaaaaaaaa aaaaaaaaaa   4380

aaaaaaaaaa agcatgatcc aactgtatgc tgtcttcaac agacatatct cacatggatc   4440

cataggctta aagtaaaggg atgaagaaaa atctaccaag ccaatggaaa acagaaaata   4500

gctggggttg acagtcgaat ttcagtcaaa acagacttta aaccaacaat gatcaagaaa   4560

gacaaaggaa gacattacag aatagtaaag ggttcaatac aacagaaaga tgttactatt   4620

gtaaatatat atgcatccaa cacaggagaa tccagattca taaagcaagt tcttagagac   4680

ctatgaagag atgtagataa ctggacaata atagtagtag acttcaacac cccacagaca   4740

gtatattaca cagatcactg aggcagaaaa ctcacaaaaa tatccaggat tcaaactcaa   4800

cattgaccaa atggactcaa tacacatctg tagaactctc caccaaacaa caccagaata   4860

tatattctac tcatctgcac agagcacaca ctgcaaaaga gaaaacacaa ttagccataa   4920

aataatcctc aggaaatc                                                 4938


<210>  2979
<211>  61
<212>  PRT
<213>  Homo sapiens

<400>  2979


Met Cys His Glu His Met Lys Lys His Arg Asn Met Lys Lys Thr Arg 
1               5                   10                  15      


Arg Gln Lys Ser Leu Thr Ser Gly Trp Leu Tyr Arg Asn Lys Ala Asp 
            20                  25                  30          


Ser Gly Trp Ser Ala Val Val Arg Ser Gln Leu Thr Ala Ala Leu Thr 
        35                  40                  45              


Ser Trp Ala Gln Val Ile Leu Leu Pro Gln Ser Pro Gln 
    50                  55                  60      

<210>  2980
<211>  521
<212>  DNA
<213>  Homo sapiens

<400>  2980
agaaacttca tctgcattgg cttcggcaaa gcagaaattt attagcttac aagggagagt     60

ggattgtcat tgagacatat gttctgctta cgtggagagt aacttgagca acgttaccca    120

cctctatgtg gaaacacagg tttatttagt atgttgaaat tccagacata actatctgtt    180

cagtagcagt ggttcctata agacaacaac ttcactgttc attttgtgct agtagaatgg    240

aacttcacgg accttggaga agcatactcc aaacactaca aatgatggtt atactttgga    300

gagatgctaa gacagcagat gctaaaatcc agataccttt tgtgaatatg aggcatatct    360

actgggaaca catcataata atctgttgag gtaaacatta aagatggtgg caataagcag    420

ttggagaaaa agaaaaatat caacatgcaa ggcaccattg ttttcttgct tcttaattgt    480

aactttttat tttttgtgta tatggctatc acagagattt a                        521


<210>  2981
<211>  50
<212>  PRT
<213>  Homo sapiens

<400>  2981


Met Glu Leu His Gly Pro Trp Arg Ser Ile Leu Gln Thr Leu Gln Met 
1               5                   10                  15      


Met Val Ile Leu Trp Arg Asp Ala Lys Thr Ala Asp Ala Lys Ile Gln 
            20                  25                  30          


Ile Pro Phe Val Asn Met Arg His Ile Tyr Trp Glu His Ile Ile Ile 
        35                  40                  45              


Ile Cys 
    50  

<210>  2982
<211>  342
<212>  DNA
<213>  Homo sapiens

<400>  2982
tgtactggga tattgtgttg cccctctccc ctctctacct gtgctgggct ttaaggctga     60

cacacctata aaccccagga gtggagggaa gggagagtgg attgtcattg agacatatgt    120

tctgcttacg tggagagtaa cttgagcaac gttacccacc tctatgtgga aacacaggtt    180

tatttaaatg gaacttcacg gaccttggag aagcatactc caaacactac aaatgatggt    240

tatactttgg agagatgcta agacagcaga tgctaaaatc cagatacctt ttgtgaatat    300

gaggcatatc tactgggaac acatcataat aatctgttga gg                       342


<210>  2983
<211>  50
<212>  PRT
<213>  Homo sapiens

<400>  2983


Met Glu Leu His Gly Pro Trp Arg Ser Ile Leu Gln Thr Leu Gln Met 
1               5                   10                  15      


Met Val Ile Leu Trp Arg Asp Ala Lys Thr Ala Asp Ala Lys Ile Gln 
            20                  25                  30          


Ile Pro Phe Val Asn Met Arg His Ile Tyr Trp Glu His Ile Ile Ile 
        35                  40                  45              


Ile Cys 
    50  

<210>  2984
<211>  487
<212>  DNA
<213>  Homo sapiens

<400>  2984
atgacagaaa cttcatctgc attggcttcg gcaaagcaga aatttattag cttacaaggc     60

cccatcttgt ccatgcacct gtctgcttcc ttggcttcag agcattgcct ccaagtcctc    120

tacagcacaa ctttcccttc agcatccaac cttatgatgt actgggatat tgtgttgccc    180

ctctcccctc tctacctgtg ctgggcttta aggctgacac acctataaac cccaggagtg    240

gagggaaggg agagtggatt gtcattgaga catatgttct gcttacgtgg agagtaactt    300

gagcaacgtt acccacctct atgtggaaac acaggtttat ttagtatgtt gaaattccag    360

acataactat ctgttcagta gcagtggttc ctataagaca acaacttcac tgttcatttt    420

gtgctagtag aatggaactt cacggacctt ggagaagcat actccaaaca ctacaaatga    480

tggttat                                                              487


<210>  2985
<211>  75
<212>  PRT
<213>  Homo sapiens

<400>  2985


Met Thr Glu Thr Ser Ser Ala Leu Ala Ser Ala Lys Gln Lys Phe Ile 
1               5                   10                  15      


Ser Leu Gln Gly Pro Ile Leu Ser Met His Leu Ser Ala Ser Leu Ala 
            20                  25                  30          


Ser Glu His Cys Leu Gln Val Leu Tyr Ser Thr Thr Phe Pro Ser Ala 
        35                  40                  45              


Ser Asn Leu Met Met Tyr Trp Asp Ile Val Leu Pro Leu Ser Pro Leu 
    50                  55                  60                  


Tyr Leu Cys Trp Ala Leu Arg Leu Thr His Leu 
65                  70                  75  

<210>  2986
<211>  162
<212>  DNA
<213>  Homo sapiens

<400>  2986
aatttgcaac atggagctcg ctaattccta tctaattttc cagatatgat ggctctggta     60

ggccaaaaga taaaaacaag caagaaagca aacaaataaa agtaacaaca aaatttaaga    120

accccttgca tggaaggatg cttatttcct ctggactgaa ag                       162


<210>  2987
<211>  4461
<212>  DNA
<213>  Homo sapiens

<400>  2987
agagcagact cagctttagg tgctgaaatg aatttctcaa ggccttttac agactccaaa     60

tagatggtcc tgagctgata ctgtcattgt caccatgatc ctggagacac agcctgtagc    120

tgtgtggaag taaacttcta aaacctgtct cttctgagag ttactgcatg aaaacaggca    180

aggatgggtc aagttttgga ccagcagccc aagttccacc aaccactctg ttatacagag    240

gcttctaagc tatgcagagt gctatgaagg gtttattctt cttttgccca cctgactgat    300

atactgatgt actttttgaa gaagggcaat ggaatttacc tagacgtcac tgtggtcttg    360

atgtggctga agtgttttgt tgaaggctct ttagtcctgt actcatttag attgactctc    420

acttctggtc cctttttgtg gtgcagacta aagcctcaaa ctctgtaaaa gacaatggct    480

tgtctcatga agagaagtga ccaactgtta ataagcttta tccaaagagg gtcgtggaaa    540

acaagaaaat gcaaaagtga ggttctcttc aatttcatat gcaattaaca aatatccaga    600

gctgactgat tggtgctcct cttccatgtg acttttggct ggctgtattt aaggatcatc    660

actccattca gaaggctaat gctgtgtgct gagaacagaa aggagatgga ggattggatc    720

agctcactga agtctgtaca gaccagagaa ccctacgagg tggcccagtt taatgtggaa    780

catttctcag ggatgcacaa ctggtacgcc tgctcccacg cccgacccac cttctgtaac    840

gtgtgcagag agagtctttc tggagtcacc tcccatggcc tgtcctgcga agtgtgtaaa    900

ttcaaggctc acaaaagatg tgcagtgaga gcaacaaata actgtaaatg gactaccctg    960

gcctccatcg ggaaggacat tatagaagat gaagatggcg tcgcgatgcc tcaccagtgg   1020

cttgagggca acctgcctgt aagtgccaag tgtgctgtct gcgacaaaac atgtggcagt   1080

gttctccgtc tacaggattg gaaatgcctt tggtgtaaga caatggtaca cactgcctgc   1140

aaagatttat accatccaat atgtccactt ggtcaatgta aagtatctat catacctcca   1200

attgcactaa acagcaccga ttccgatggt ttctgtagag caacattttc gttctgtgtt   1260

agtcctctat tggtttttgt caattctaag agtggagata atcagggagt aaagttcctc   1320

cgtcgcttta aacagttgct aaatccggct caggtgtttg atttaatgaa tggaggtcct   1380

catttaggtt taagattatt tcagaagttt gacaatttcc ggattcttgt ttgtggaggc   1440

gatggaagtg taggttgggt tttgtcagaa atcgataagc tcaacttgaa taaacaggca   1500

actgggagtg ttgcctttgg gtacaggaaa tgaccttgcc cgagttcttg gctggggagg   1560

ttcatatgac gatgacaccc aacttcctca gatcctagag aaactggaac gagccagtac   1620

caaaatgttg gacaggtgga gtataatgac atatgaactc aaattgccac caaaagcttc   1680

cctacttcca ggacctccag aagcatctga agaattttat atgacgattt atgaagactc   1740

agttgcaacg catcttacaa aaatcctcaa ttctgatgaa catgcagtgg tcatatcttc   1800

tgccaagacg ctatgtgaaa ctgtaaagga cttcgttgcc aaagtagaaa agacgtatga   1860

caaaaccttg gaaaatgccg ttgtagctga tgccgtggcc agtaaatgtt cagtcctaaa   1920

cgagaagctc gaacaactgc tgcaggcttt gcacacagat tcccaggctg cgcctgttct   1980

ccctggcctc agccctctca ttgtggaaga agatgctgtg gaatcgtcca gtgaagagtc   2040

cctgggtgaa agcaaagagc agcttgggga tgacgttaca aaaccttcct cccagaaagc   2100

cgtcaaacca agggaaatca tgttgcgggc aaatagttta aagaaagcag tgaggcaagt   2160

cattgaggaa gccggaaaag ttatggatga cccgacagtt cacccctgtg aaccagctaa   2220

tcagtcctct gattatgaca gcacagaaac agatgaatct aaggaggaag ctaaagatga   2280

tggtgccaaa gaatcaataa ctgttaaaac tgcacctcgg tctccagatg cccgggcaag   2340

ttatggccat tcccaaactg attctgtccc tggtccagct gtggcagcca gcaaagaaaa   2400

cctccctgtg ctcaatacca gaataatctg cccaggcaat gatttctcag atatgacaag   2460

cacacgccac aaaagacaaa taaattggac ttcaccgaaa tgaatagttt tgtgattcaa   2520

aggacactat cgagaaagtg aaatgacaat ttaagaattt acaaataata tatctgataa   2580

aggactagta tccagaacat ataaagaacc cttaaaattc aacaataaaa aggtttaaga   2640

gcaggactgg ctgcctcaat tgctgggagt tcgattatca acaaaatgtt actggcaaac   2700

attgatcctt ttggtgccac gccgtttatt gacccggatc tagattccgt agatggatat   2760

tcagaaaaat gtgtcatgaa caattacttt gggattggat tagatgcaaa aatttcatta   2820

gaatttaata ataaaagaga ggagcaccct gaaaaatgca ggagccgaac taaaaacttg   2880

atgtggtatg gagtccttgg aacccgggag ttattacaga gatcgtacaa gaatttagaa   2940

caaagggttc aacttgagtg tgatgggcag tatattcctc ttcccagctt gcaaggcata   3000

gccgtgttga acattcccag ctatgctgga ggcactaact tttggggtgg aactaaagag   3060

gatgatatat ttgctgcacc atcctttgat gacaagatcc tggaagttgt agcaatattt   3120

gatagcatgc aaatggcagt ttcaagggtc attaaactgc agcatcatcg aatagcccag   3180

tgccgtacag tgaaaatcac tatatttggt gacgaaggag tcccagtgca agtggatggt   3240

gaagcgtggg ttcagcctcc agggattatc aaaattgtgc acaaaaacag agcacaaatg   3300

ctaacaaggg acagagcctt tgagagcact ctgaaatctt gggaagataa gcagaagtgt   3360

gattctggta aaccagttct ccgaacccat ttgtacatcc atcacgccat tgacttggca   3420

acagaagagg tgtcgcagat gcagctatgc tcccaggctg cagaggagct cattactagg   3480

atatgtgacg cagccacaat tcactgtctt ttggagcaag aactggccca tgctgtgaat   3540

gcctgctccc atgccctgaa taaagccaac ccaaggtgcc cggagagtct tacaagagac   3600

actgccactg aaatagccat caatgtgaag gcgctgtata atgaaacaga atctttgcta   3660

gttggcaggg ttcctttgca gctggaatcg ccacatgaag agcgagtatc caatgcctta   3720

cactctgtgg aggtggaatt acagaaactg acagagattc cttggcttta ttatatctta   3780

cacccaaatg aggatgagga acctcctatg gattgcacca aaaggaacaa cagaagcacc   3840

gtatttcgaa tagtgccaaa gtttaaaaag gaaaaggttc agaagcagaa gacaagttca   3900

cagcctggat ctggggatac cgaaagtggg tcatgtgaag cgaattctcc agggaattaa   3960

agagcttgga aggagcactc cacagtcgga ggtgtaatca tattggtgct atttcttgga   4020

agagaagtta ttgccactta atacaaagtc cttggaagca agtggctgtt cttgtagttt   4080

tctgcataga taaaggatat atatgagttc aagatggtca cctgcttctc taggaatcca   4140

agggacaact tcaattcctt taggagtttc ctttacagaa aactgcgtgg tgggaatcca   4200

ggccaataca gaaaggatca acaagctgat gaatgagtct caaatgttgg tgacagctct   4260

caatcctcgt atagcgtatg acaaggcagc aaagattgct aagacagcac acaaaaatgg   4320

atcaacctta aaggaaactg ttattgaact tggctatctc acaccagaac agtttgatga   4380

acaggtaaaa actaaggaca tgctgagtcc aaagtgattt aagtaaattt ataatgaaaa   4440

taaacgtgta tataattttt t                                             4461


<210>  2988
<211>  424
<212>  PRT
<213>  Homo sapiens

<400>  2988


Met Leu Leu Ala Asn Ile Asp Pro Phe Gly Ala Thr Pro Phe Ile Asp 
1               5                   10                  15      


Pro Asp Leu Asp Ser Val Asp Gly Tyr Ser Glu Lys Cys Val Met Asn 
            20                  25                  30          


Asn Tyr Phe Gly Ile Gly Leu Asp Ala Lys Ile Ser Leu Glu Phe Asn 
        35                  40                  45              


Asn Lys Arg Glu Glu His Pro Glu Lys Cys Arg Ser Arg Thr Lys Asn 
    50                  55                  60                  


Leu Met Trp Tyr Gly Val Leu Gly Thr Arg Glu Leu Leu Gln Arg Ser 
65                  70                  75                  80  


Tyr Lys Asn Leu Glu Gln Arg Val Gln Leu Glu Cys Asp Gly Gln Tyr 
                85                  90                  95      


Ile Pro Leu Pro Ser Leu Gln Gly Ile Ala Val Leu Asn Ile Pro Ser 
            100                 105                 110         


Tyr Ala Gly Gly Thr Asn Phe Trp Gly Gly Thr Lys Glu Asp Asp Ile 
        115                 120                 125             


Phe Ala Ala Pro Ser Phe Asp Asp Lys Ile Leu Glu Val Val Ala Ile 
    130                 135                 140                 


Phe Asp Ser Met Gln Met Ala Val Ser Arg Val Ile Lys Leu Gln His 
145                 150                 155                 160 


His Arg Ile Ala Gln Cys Arg Thr Val Lys Ile Thr Ile Phe Gly Asp 
                165                 170                 175     


Glu Gly Val Pro Val Gln Val Asp Gly Glu Ala Trp Val Gln Pro Pro 
            180                 185                 190         


Gly Ile Ile Lys Ile Val His Lys Asn Arg Ala Gln Met Leu Thr Arg 
        195                 200                 205             


Asp Arg Ala Phe Glu Ser Thr Leu Lys Ser Trp Glu Asp Lys Gln Lys 
    210                 215                 220                 


Cys Asp Ser Gly Lys Pro Val Leu Arg Thr His Leu Tyr Ile His His 
225                 230                 235                 240 


Ala Ile Asp Leu Ala Thr Glu Glu Val Ser Gln Met Gln Leu Cys Ser 
                245                 250                 255     


Gln Ala Ala Glu Glu Leu Ile Thr Arg Ile Cys Asp Ala Ala Thr Ile 
            260                 265                 270         


His Cys Leu Leu Glu Gln Glu Leu Ala His Ala Val Asn Ala Cys Ser 
        275                 280                 285             


His Ala Leu Asn Lys Ala Asn Pro Arg Cys Pro Glu Ser Leu Thr Arg 
    290                 295                 300                 


Asp Thr Ala Thr Glu Ile Ala Ile Asn Val Lys Ala Leu Tyr Asn Glu 
305                 310                 315                 320 


Thr Glu Ser Leu Leu Val Gly Arg Val Pro Leu Gln Leu Glu Ser Pro 
                325                 330                 335     


His Glu Glu Arg Val Ser Asn Ala Leu His Ser Val Glu Val Glu Leu 
            340                 345                 350         


Gln Lys Leu Thr Glu Ile Pro Trp Leu Tyr Tyr Ile Leu His Pro Asn 
        355                 360                 365             


Glu Asp Glu Glu Pro Pro Met Asp Cys Thr Lys Arg Asn Asn Arg Ser 
    370                 375                 380                 


Thr Val Phe Arg Ile Val Pro Lys Phe Lys Lys Glu Lys Val Gln Lys 
385                 390                 395                 400 


Gln Lys Thr Ser Ser Gln Pro Gly Ser Gly Asp Thr Glu Ser Gly Ser 
                405                 410                 415     


Cys Glu Ala Asn Ser Pro Gly Asn 
            420                 

<210>  2989
<211>  872
<212>  DNA
<213>  Homo sapiens

<400>  2989
atgaagccac ctgcctctgc cagggtgaga accagtgccc ctgagacact ggcagcaaca     60

gtgagcaaaa cagaaagggc aagtcctctt ttcttctgca ggaaagcagc tggcaaagca    120

gcagtgctga tcgcagagcc caatgccagc atcactgagc agagtagact gatagagaag    180

gttgctgcaa aattggctgc acgtacaggc ttgccttttg tcactgctcc aaataaattt    240

gaagctctgg ctgctcatga cgctctggtt gagctcagtg gagccatgaa cactactgcc    300

tgtagtctga tgacgatagc aaataatatt cgttttctgg gttctggccc ttggtcaggt    360

ctgggagaac tgatcttgcc tgaaaatgaa ccaggaagta gtatcatgcc aggcaaggtg    420

aaccctactc agtgtgaagc aatgaccatg gttgtagccc aagtcatggg gaatcatgtt    480

gctgtaacag ttggaggcag cagtggacat tttgagttga atgttttcaa gccaatgatg    540

attaaaaatg tgttacactc agccaggctg ctggcggatg cttcagtttc ctttacagaa    600

aactgcgtgg tgggaatcca ggccaataca gaaaggatca acaagctgat gaatgagtct    660

caaatgttgg tgacagctct caatcctcgt atagcgtatg acaaggcagc aaagattgct    720

aagacagcac acaaaaatgg atcaacctta aaggaaactg ttattgaact tggctatctc    780

acaccagaac agtttgatga acaggtaaaa actaaggaca tgctgagtcc aaagtgattt    840

aagtaaattt ataatgaaaa taaacgtgta ta                                  872


<210>  2990
<211>  278
<212>  PRT
<213>  Homo sapiens

<400>  2990


Met Lys Pro Pro Ala Ser Ala Arg Val Arg Thr Ser Ala Pro Glu Thr 
1               5                   10                  15      


Leu Ala Ala Thr Val Ser Lys Thr Glu Arg Ala Ser Pro Leu Phe Phe 
            20                  25                  30          


Cys Arg Lys Ala Ala Gly Lys Ala Ala Val Leu Ile Ala Glu Pro Asn 
        35                  40                  45              


Ala Ser Ile Thr Glu Gln Ser Arg Leu Ile Glu Lys Val Ala Ala Lys 
    50                  55                  60                  


Leu Ala Ala Arg Thr Gly Leu Pro Phe Val Thr Ala Pro Asn Lys Phe 
65                  70                  75                  80  


Glu Ala Leu Ala Ala His Asp Ala Leu Val Glu Leu Ser Gly Ala Met 
                85                  90                  95      


Asn Thr Thr Ala Cys Ser Leu Met Thr Ile Ala Asn Asn Ile Arg Phe 
            100                 105                 110         


Leu Gly Ser Gly Pro Trp Ser Gly Leu Gly Glu Leu Ile Leu Pro Glu 
        115                 120                 125             


Asn Glu Pro Gly Ser Ser Ile Met Pro Gly Lys Val Asn Pro Thr Gln 
    130                 135                 140                 


Cys Glu Ala Met Thr Met Val Val Ala Gln Val Met Gly Asn His Val 
145                 150                 155                 160 


Ala Val Thr Val Gly Gly Ser Ser Gly His Phe Glu Leu Asn Val Phe 
                165                 170                 175     


Lys Pro Met Met Ile Lys Asn Val Leu His Ser Ala Arg Leu Leu Ala 
            180                 185                 190         


Asp Ala Ser Val Ser Phe Thr Glu Asn Cys Val Val Gly Ile Gln Ala 
        195                 200                 205             


Asn Thr Glu Arg Ile Asn Lys Leu Met Asn Glu Ser Gln Met Leu Val 
    210                 215                 220                 


Thr Ala Leu Asn Pro Arg Ile Ala Tyr Asp Lys Ala Ala Lys Ile Ala 
225                 230                 235                 240 


Lys Thr Ala His Lys Asn Gly Ser Thr Leu Lys Glu Thr Val Ile Glu 
                245                 250                 255     


Leu Gly Tyr Leu Thr Pro Glu Gln Phe Asp Glu Gln Val Lys Thr Lys 
            260                 265                 270         


Asp Met Leu Ser Pro Lys 
        275             

<210>  2991
<211>  895
<212>  DNA
<213>  Homo sapiens

<400>  2991
atgcgaaggc gcagctctcg ggcggccccg aagccagaag ggggaccagc ggcaggcgga     60

ggggctggag cgccggagcc gggccgctcc atccatgccg gccgcacacc cgccgccacc    120

ccatctaaac gcagcctccg cggcgagcac gtcggcgccc ggctcacctg ggggccgcag    180

cctccgcagc tcacagacat gtcaccggcc tcaacgaccc tgcagcccgc ggagcagccc    240

gcggggcagc cccgctggtc acatgactta aagggggcct ctccattggc cgggacccac    300

tcagccttgg gagctttaaa ttcgagggcg acctacgaac ctgcggcgga cgtcttgcgc    360

gcttcctggt ccgttgcctt ggaaacggct taacccttcc ctctggcaag tccccaggcc    420

ttggcttgct ccgcagattt ggtttcaggc tctgcctctt ttccctcgac cccttagtct    480

taacagcctg gggccagctg ggctccttct tcgccacaag gctagttttg ctttcttccg    540

aagcccgggg cccttcccaa agtggcagcc ccaccagatc cgaaggccca aggaaggctc    600

atcctttctg atggctccgc cccttctccc agcatctccg gggaggacca ctcacagcgc    660

accgggcaac cagccctatc ccagccaaga agtagcttcc agggttctca gggccctagt    720

gctcaccctg atgtctttac gtggtatgga aatcggaaag taaagctttg gtcactggga    780

agcctagcca gagatgaaaa gctgttatgg tgattatttt cacctaaaat cggaagggcc    840

agtccagtca aattgccctg tctcctaaag ggcatctgtt cctcaagagt ggaaa         895


<210>  2992
<211>  130
<212>  PRT
<213>  Homo sapiens

<400>  2992


Met Arg Arg Arg Ser Ser Arg Ala Ala Pro Lys Pro Glu Gly Gly Pro 
1               5                   10                  15      


Ala Ala Gly Gly Gly Ala Gly Ala Pro Glu Pro Gly Arg Ser Ile His 
            20                  25                  30          


Ala Gly Arg Thr Pro Ala Ala Thr Pro Ser Lys Arg Ser Leu Arg Gly 
        35                  40                  45              


Glu His Val Gly Ala Arg Leu Thr Trp Gly Pro Gln Pro Pro Gln Leu 
    50                  55                  60                  


Thr Asp Met Ser Pro Ala Ser Thr Thr Leu Gln Pro Ala Glu Gln Pro 
65                  70                  75                  80  


Ala Gly Gln Pro Arg Trp Ser His Asp Leu Lys Gly Ala Ser Pro Leu 
                85                  90                  95      


Ala Gly Thr His Ser Ala Leu Gly Ala Leu Asn Ser Arg Ala Thr Tyr 
            100                 105                 110         


Glu Pro Ala Ala Asp Val Leu Arg Ala Ser Trp Ser Val Ala Leu Glu 
        115                 120                 125             


Thr Ala 
    130 

<210>  2993
<211>  5302
<212>  DNA
<213>  Homo sapiens

<400>  2993
ggagaagggg cggagccatc agaaaggatg agccttcctt gggccttcgg atctggtggg     60

gctgccactt tgggaagggc cccgggcttc ggaagaaagc aaaactagcc ttgtggcgaa    120

gaaggagccc agctggcccc aggctgttaa gactaagggg tcgagggaaa agaggcagag    180

cctgaaacca aatctgcgga gcaagccaag gcctggggac ttgccagagg gaagggttaa    240

gccgtttcca aggcaacgga ccaggaagcg cgcaagacgt ccgccgcagg tgttttgtgg    300

attaactctt cattgattat atacaacaaa aaatagttat ggcgactttc agaaacaatc    360

acatgaagac taaagcatct gtcagaaaaa gcttcagtga agatgtgttc cagtctgtaa    420

agtctttatt gcagagtcag aaggaactat gcagtgtaac agcagaggac tgtttacagc    480

aggatgagca tgccaattta actgaggtca catttctggg ttttaatgaa gagacagatg    540

ctgctcatat acaggattta gctgcagttt ctttggaact tccagatatt ctgaattcac    600

tccacttctg cagtctaaat gaaaatgaaa ttatttgtat gaagaatata aataaaccat    660

tagatataag cagtgatcct ctaaatcaga gtcatccttc tggaatgctt tgtgtcatga    720

gagtgtcacc tacatcacca agacttagga ttgattttat ctttagtctc ctaagtaaat    780

atgctactgg tataaggtac accttggaca cattcttgca tcagaagcac caacttgaga    840

ccactgatga agatgatgat gatactaacc agtctgtgtc atccatagag gatgactttg    900

tcactgcttt tgagcactta gaagaggaag agacttcaaa gccatacaat gatggaatga    960

acattactgt gctaaggagc cagtgtgatg ctgcttccca gacggttact ggtcatcatt   1020

tagaaaccca tgatttaaag attctcatta gctctggaca gcagaagtca ttggctaaac   1080

cctcaacttc ctcagtgaat gtcctgggac ataaagaact accttctgtg aaaacttcag   1140

tcacaacatc aatttcagag ccttggaccc aaaggagttt ctataggtca tctaatgctt   1200

cagataaaga tagtgattta cagaaaacat ttttttcgtc ttctcctgcc tactcatctg   1260

aatcagaatg ttcaagtcca agtcctgtta ttttcttgga tgaagaggga tatcaaaaaa   1320

gcttaaaagc aaaacttgag ctgcctaaaa ttcctgtgat gaaagatgat atagaggatt   1380

cagactcaga agtaagtgaa ttttttgata gttttgatca gtttgatgaa ctagaacaaa   1440

ctttagagac ttgcctgttt aacaaagatc ccgtcatagg gaagtcatcg cagaggaaag   1500

ggcacaaaca tggaaagtca tgtatgaatc ctcaaaaatt caagtttgat cgtccagctc   1560

tcccagctaa tgttagaaag ccaactcctc gtaaaccaga atctccatat ggtaacctgt   1620

gtgatgctcc ggattctcct cgcccagtga aggcatcaag ggaagatagt ggtttattta   1680

gtcctattcg atcctctgct tttagtcctc ttggaggctg tactccagct gaatgttttt   1740

gccaaacaga tattggtgga gataggattc atgaaaatca tgattctgtt tattacacct   1800

atgaagacta tgcaaaaagc atttcatgtg aagtactagg ctcagttctt cgtacccacc   1860

atactaatac cctatcaaat attaacagta ttaaacatgg agaaaataaa actgtaactt   1920

ttaagcatgg aaaccttgat caaaaaaata aatctaaaaa taaatcctta atgattaaag   1980

atagcattca aaaatttgca gcagatcttg tggaaaaaag ttttggcagt gcatttaaag   2040

acttacagaa aggagtctct tcatgtacca atgctttgta ccacttagcc atcaaattga   2100

catcatctgt tttgcagatg gcatttgatg agctgagaag gcagcgtgca ttttcactaa   2160

aagaacgtgc cattagtggc ctggctaact ttttggtgag tgaagcttta tcaaatgcct   2220

taaaagattt acagtatgta aagaagcaga tattcacaaa cacagttgct aggtttgctg   2280

cagatcttgc tgaagagctt gtttttgaag gcatcatgga ggtgtgtcag ttttcatatc   2340

ctcaaacgcc tgcatctcca cagtgtgggt cgtttgactt tgaagacaaa gtagtgaagt   2400

tgtatgcaaa agatttgtct gaatctgtaa tacaggaagc attcattgag ctatcacaag   2460

ttgatgtgac ctttacaaca aaggcagcag ttagtgtctc tacggataat atcaagtatg   2520

tgagtgcaga aagtgtagtg ccatcgacac aggctgtcac gttttcccct tcttttcaca   2580

atcaagcaat tatggtgaca aaaccagtgc aggaatataa aaaggaatac acagtgcagc   2640

aggccttgtt ttgtacttct ggaattgtta cttctatacc ggtgcccttg gcaggaagtg   2700

cccttctccc atatcatatt tcatctactg catgtcaggc caaggctcat ctgtcatctg   2760

atgatagtaa ttcaaatggt gattctgccc aagtgcatat tgccacaaaa aacagagaag   2820

aaaaagcagc ttgtctcaga aatatttgtt taccttcaga acacaatcca ggtaatcaga   2880

atgattttaa accaactaat gacgatattg aaatgcagag ttcctcaaaa ttaccaaatg   2940

atcctgcaat tattagcaac ttttctgcag cagtggtgca tacgatagta aatgaaactt   3000

tagagtcaat gacatcattg gaagttacaa aaatggttga tgaacgtaca gattatttaa   3060

ctaaatcttt aaaggagaaa acccctccat tttcccactg tgatcaggca gtgctgcaat   3120

gcagtgaagc tagtagcaat aaggacatgt ttgctgaccg gttatctaaa tctattatta   3180

aacattccat agataagagc aaatcagtga tcccaaatat agataaaaat gcagtataca   3240

aggaaagctt gcctgtttct ggagaagaat cacagttgac accagaaaag tctcccaaat   3300

ttcctgactc tcagaatcag ttaactcact gctcactttc agctgcaaag gattgtgttc   3360

cagaatgtaa agtttctatg gttcatggat cctccctaga gacactgcca tcttgtccag   3420

ctgtgacagg tcagaaatct gacttgaagg aatctgctaa ggatcaacca ctgaaaaagc   3480

ataacttgaa tagtacatca cttgaggcct tgtcttttgg acaggaaaac ccctttcctc   3540

attcacatac tttctcatct acagcactta cctgtgtaga tggtttgcat gtggaagata   3600

aacagaaagt cagagacaga aatgtaatac ctgatactcc tccatcaact cctctagtac   3660

catcccgggc tagttctgaa tgggatatca agaagttaac taaaaagctc aagggagaat   3720

tagccaaaga gtttgcacct gctacaccac cttctactcc acacaactca tctgttggta   3780

gtttgtctga gaatgaacaa aatactatag aaaaagaaga gttcatgttg aaactcatgc   3840

gatctctttc tgaagaagtt gagagtagtg aaagtggaga gctcccagaa gtggatgtga   3900

agtcggagca ctcagggaag aaggttcagt ttgcagaagc attagctaca cacatccttt   3960

ctcttgcaac tgaaatggca gcttcccatt tagataacaa aataattcaa gaacccaagg   4020

ttaaaaaccc ttgcttaaat gtgcaaagtc aaagaagtgt gtcgcctact tttttaaacc   4080

cctcagacga aaatttgaaa acattatgca attttgcggg tgatctggca gcagaagtca   4140

ttacagaagc tgagaaaata gcaaaagtcc gaaattgtat gcttttcaag caaaagaaga   4200

acagttgtta tgctgatggt gacgaagatt ataaagtaga agagaagttg gatatagagg   4260

ctgtagtgca cccaagagaa gtggatccgt ttattctttc attaccacca agttcttgta   4320

tgtcaggtct gatgtataag tatcccagct gtgaaagtgt gacagatgaa tatgcaggtc   4380

accttattca gatactaaaa caggaaggtg gtaatagtga gttgataatg gatcagtatg   4440

ccaataggct tgcctaccga tctgttaaat caggattaca ggaagcagct aagacaacca   4500

aagtgcagtg caactcaaga atgttccctg tgccaagttc acaagtgaaa acaaacaagg   4560

aactgttaat gttttcaaac aaagagcacc accaagaagc agacaaaaag agacaaagta   4620

aaagaaatga aggttacttt tgtaaaaatc aaacttgtga aaggaccctg gatccatata   4680

gaaatgaggt ctcccaactg tatagttttt caacctctct ggttcacagc ataacaaaag   4740

atgctaagga agagttgaca gcctctctag ttggcctacc aaaatcctta acagattctt   4800

gcttgtttga aaaatctgga tatgaagaag ataatgagtg tcacgttaca ccagaattgc   4860

ctaagtctct tcagccttcc tcacaaaatc acaggtttta ccacagcact ggcagtttaa   4920

atggatatgg ttgtggagac aatgttgttc aagctgtaga acagtatgcc aaaaaagtag   4980

tggatgacac tctagagcta actctaggat ctacagtgtt ccgagtgtct gagaccacaa   5040

aatcagcaga cagggtcact tatgcagaaa agttgtcacc tcttacaggt caagcttgca   5100

gatactgtga ccttaaagaa ctccacaatt gcactggaaa ttcatctcag cactttttca   5160

gacagggttc tctcgccagt agtaagccag cttctaatcc aaaatttagc agccgctatc   5220

agaaatctag gatttttcat ctcagtgtcc ctcagattca tgttaatctt gataagaagg   5280

cagtgcttgc tgagaagata gt                                            5302


<210>  2994
<211>  1653
<212>  PRT
<213>  Homo sapiens

<400>  2994


Met Ala Thr Phe Arg Asn Asn His Met Lys Thr Lys Ala Ser Val Arg 
1               5                   10                  15      


Lys Ser Phe Ser Glu Asp Val Phe Gln Ser Val Lys Ser Leu Leu Gln 
            20                  25                  30          


Ser Gln Lys Glu Leu Cys Ser Val Thr Ala Glu Asp Cys Leu Gln Gln 
        35                  40                  45              


Asp Glu His Ala Asn Leu Thr Glu Val Thr Phe Leu Gly Phe Asn Glu 
    50                  55                  60                  


Glu Thr Asp Ala Ala His Ile Gln Asp Leu Ala Ala Val Ser Leu Glu 
65                  70                  75                  80  


Leu Pro Asp Ile Leu Asn Ser Leu His Phe Cys Ser Leu Asn Glu Asn 
                85                  90                  95      


Glu Ile Ile Cys Met Lys Asn Ile Asn Lys Pro Leu Asp Ile Ser Ser 
            100                 105                 110         


Asp Pro Leu Asn Gln Ser His Pro Ser Gly Met Leu Cys Val Met Arg 
        115                 120                 125             


Val Ser Pro Thr Ser Pro Arg Leu Arg Ile Asp Phe Ile Phe Ser Leu 
    130                 135                 140                 


Leu Ser Lys Tyr Ala Thr Gly Ile Arg Tyr Thr Leu Asp Thr Phe Leu 
145                 150                 155                 160 


His Gln Lys His Gln Leu Glu Thr Thr Asp Glu Asp Asp Asp Asp Thr 
                165                 170                 175     


Asn Gln Ser Val Ser Ser Ile Glu Asp Asp Phe Val Thr Ala Phe Glu 
            180                 185                 190         


His Leu Glu Glu Glu Glu Thr Ser Lys Pro Tyr Asn Asp Gly Met Asn 
        195                 200                 205             


Ile Thr Val Leu Arg Ser Gln Cys Asp Ala Ala Ser Gln Thr Val Thr 
    210                 215                 220                 


Gly His His Leu Glu Thr His Asp Leu Lys Ile Leu Ile Ser Ser Gly 
225                 230                 235                 240 


Gln Gln Lys Ser Leu Ala Lys Pro Ser Thr Ser Ser Val Asn Val Leu 
                245                 250                 255     


Gly His Lys Glu Leu Pro Ser Val Lys Thr Ser Val Thr Thr Ser Ile 
            260                 265                 270         


Ser Glu Pro Trp Thr Gln Arg Ser Phe Tyr Arg Ser Ser Asn Ala Ser 
        275                 280                 285             


Asp Lys Asp Ser Asp Leu Gln Lys Thr Phe Phe Ser Ser Ser Pro Ala 
    290                 295                 300                 


Tyr Ser Ser Glu Ser Glu Cys Ser Ser Pro Ser Pro Val Ile Phe Leu 
305                 310                 315                 320 


Asp Glu Glu Gly Tyr Gln Lys Ser Leu Lys Ala Lys Leu Glu Leu Pro 
                325                 330                 335     


Lys Ile Pro Val Met Lys Asp Asp Ile Glu Asp Ser Asp Ser Glu Val 
            340                 345                 350         


Ser Glu Phe Phe Asp Ser Phe Asp Gln Phe Asp Glu Leu Glu Gln Thr 
        355                 360                 365             


Leu Glu Thr Cys Leu Phe Asn Lys Asp Pro Val Ile Gly Lys Ser Ser 
    370                 375                 380                 


Gln Arg Lys Gly His Lys His Gly Lys Ser Cys Met Asn Pro Gln Lys 
385                 390                 395                 400 


Phe Lys Phe Asp Arg Pro Ala Leu Pro Ala Asn Val Arg Lys Pro Thr 
                405                 410                 415     


Pro Arg Lys Pro Glu Ser Pro Tyr Gly Asn Leu Cys Asp Ala Pro Asp 
            420                 425                 430         


Ser Pro Arg Pro Val Lys Ala Ser Arg Glu Asp Ser Gly Leu Phe Ser 
        435                 440                 445             


Pro Ile Arg Ser Ser Ala Phe Ser Pro Leu Gly Gly Cys Thr Pro Ala 
    450                 455                 460                 


Glu Cys Phe Cys Gln Thr Asp Ile Gly Gly Asp Arg Ile His Glu Asn 
465                 470                 475                 480 


His Asp Ser Val Tyr Tyr Thr Tyr Glu Asp Tyr Ala Lys Ser Ile Ser 
                485                 490                 495     


Cys Glu Val Leu Gly Ser Val Leu Arg Thr His His Thr Asn Thr Leu 
            500                 505                 510         


Ser Asn Ile Asn Ser Ile Lys His Gly Glu Asn Lys Thr Val Thr Phe 
        515                 520                 525             


Lys His Gly Asn Leu Asp Gln Lys Asn Lys Ser Lys Asn Lys Ser Leu 
    530                 535                 540                 


Met Ile Lys Asp Ser Ile Gln Lys Phe Ala Ala Asp Leu Val Glu Lys 
545                 550                 555                 560 


Ser Phe Gly Ser Ala Phe Lys Asp Leu Gln Lys Gly Val Ser Ser Cys 
                565                 570                 575     


Thr Asn Ala Leu Tyr His Leu Ala Ile Lys Leu Thr Ser Ser Val Leu 
            580                 585                 590         


Gln Met Ala Phe Asp Glu Leu Arg Arg Gln Arg Ala Phe Ser Leu Lys 
        595                 600                 605             


Glu Arg Ala Ile Ser Gly Leu Ala Asn Phe Leu Val Ser Glu Ala Leu 
    610                 615                 620                 


Ser Asn Ala Leu Lys Asp Leu Gln Tyr Val Lys Lys Gln Ile Phe Thr 
625                 630                 635                 640 


Asn Thr Val Ala Arg Phe Ala Ala Asp Leu Ala Glu Glu Leu Val Phe 
                645                 650                 655     


Glu Gly Ile Met Glu Val Cys Gln Phe Ser Tyr Pro Gln Thr Pro Ala 
            660                 665                 670         


Ser Pro Gln Cys Gly Ser Phe Asp Phe Glu Asp Lys Val Val Lys Leu 
        675                 680                 685             


Tyr Ala Lys Asp Leu Ser Glu Ser Val Ile Gln Glu Ala Phe Ile Glu 
    690                 695                 700                 


Leu Ser Gln Val Asp Val Thr Phe Thr Thr Lys Ala Ala Val Ser Val 
705                 710                 715                 720 


Ser Thr Asp Asn Ile Lys Tyr Val Ser Ala Glu Ser Val Val Pro Ser 
                725                 730                 735     


Thr Gln Ala Val Thr Phe Ser Pro Ser Phe His Asn Gln Ala Ile Met 
            740                 745                 750         


Val Thr Lys Pro Val Gln Glu Tyr Lys Lys Glu Tyr Thr Val Gln Gln 
        755                 760                 765             


Ala Leu Phe Cys Thr Ser Gly Ile Val Thr Ser Ile Pro Val Pro Leu 
    770                 775                 780                 


Ala Gly Ser Ala Leu Leu Pro Tyr His Ile Ser Ser Thr Ala Cys Gln 
785                 790                 795                 800 


Ala Lys Ala His Leu Ser Ser Asp Asp Ser Asn Ser Asn Gly Asp Ser 
                805                 810                 815     


Ala Gln Val His Ile Ala Thr Lys Asn Arg Glu Glu Lys Ala Ala Cys 
            820                 825                 830         


Leu Arg Asn Ile Cys Leu Pro Ser Glu His Asn Pro Gly Asn Gln Asn 
        835                 840                 845             


Asp Phe Lys Pro Thr Asn Asp Asp Ile Glu Met Gln Ser Ser Ser Lys 
    850                 855                 860                 


Leu Pro Asn Asp Pro Ala Ile Ile Ser Asn Phe Ser Ala Ala Val Val 
865                 870                 875                 880 


His Thr Ile Val Asn Glu Thr Leu Glu Ser Met Thr Ser Leu Glu Val 
                885                 890                 895     


Thr Lys Met Val Asp Glu Arg Thr Asp Tyr Leu Thr Lys Ser Leu Lys 
            900                 905                 910         


Glu Lys Thr Pro Pro Phe Ser His Cys Asp Gln Ala Val Leu Gln Cys 
        915                 920                 925             


Ser Glu Ala Ser Ser Asn Lys Asp Met Phe Ala Asp Arg Leu Ser Lys 
    930                 935                 940                 


Ser Ile Ile Lys His Ser Ile Asp Lys Ser Lys Ser Val Ile Pro Asn 
945                 950                 955                 960 


Ile Asp Lys Asn Ala Val Tyr Lys Glu Ser Leu Pro Val Ser Gly Glu 
                965                 970                 975     


Glu Ser Gln Leu Thr Pro Glu Lys Ser Pro Lys Phe Pro Asp Ser Gln 
            980                 985                 990         


Asn Gln Leu Thr His Cys Ser Leu  Ser Ala Ala Lys Asp  Cys Val Pro 
        995                 1000                 1005             


Glu Cys  Lys Val Ser Met Val  His Gly Ser Ser Leu  Glu Thr Leu 
    1010                 1015                 1020             


Pro Ser  Cys Pro Ala Val Thr  Gly Gln Lys Ser Asp  Leu Lys Glu 
    1025                 1030                 1035             


Ser Ala  Lys Asp Gln Pro Leu  Lys Lys His Asn Leu  Asn Ser Thr 
    1040                 1045                 1050             


Ser Leu  Glu Ala Leu Ser Phe  Gly Gln Glu Asn Pro  Phe Pro His 
    1055                 1060                 1065             


Ser His  Thr Phe Ser Ser Thr  Ala Leu Thr Cys Val  Asp Gly Leu 
    1070                 1075                 1080             


His Val  Glu Asp Lys Gln Lys  Val Arg Asp Arg Asn  Val Ile Pro 
    1085                 1090                 1095             


Asp Thr  Pro Pro Ser Thr Pro  Leu Val Pro Ser Arg  Ala Ser Ser 
    1100                 1105                 1110             


Glu Trp  Asp Ile Lys Lys Leu  Thr Lys Lys Leu Lys  Gly Glu Leu 
    1115                 1120                 1125             


Ala Lys  Glu Phe Ala Pro Ala  Thr Pro Pro Ser Thr  Pro His Asn 
    1130                 1135                 1140             


Ser Ser  Val Gly Ser Leu Ser  Glu Asn Glu Gln Asn  Thr Ile Glu 
    1145                 1150                 1155             


Lys Glu  Glu Phe Met Leu Lys  Leu Met Arg Ser Leu  Ser Glu Glu 
    1160                 1165                 1170             


Val Glu  Ser Ser Glu Ser Gly  Glu Leu Pro Glu Val  Asp Val Lys 
    1175                 1180                 1185             


Ser Glu  His Ser Gly Lys Lys  Val Gln Phe Ala Glu  Ala Leu Ala 
    1190                 1195                 1200             


Thr His  Ile Leu Ser Leu Ala  Thr Glu Met Ala Ala  Ser His Leu 
    1205                 1210                 1215             


Asp Asn  Lys Ile Ile Gln Glu  Pro Lys Val Lys Asn  Pro Cys Leu 
    1220                 1225                 1230             


Asn Val  Gln Ser Gln Arg Ser  Val Ser Pro Thr Phe  Leu Asn Pro 
    1235                 1240                 1245             


Ser Asp  Glu Asn Leu Lys Thr  Leu Cys Asn Phe Ala  Gly Asp Leu 
    1250                 1255                 1260             


Ala Ala  Glu Val Ile Thr Glu  Ala Glu Lys Ile Ala  Lys Val Arg 
    1265                 1270                 1275             


Asn Cys  Met Leu Phe Lys Gln  Lys Lys Asn Ser Cys  Tyr Ala Asp 
    1280                 1285                 1290             


Gly Asp  Glu Asp Tyr Lys Val  Glu Glu Lys Leu Asp  Ile Glu Ala 
    1295                 1300                 1305             


Val Val  His Pro Arg Glu Val  Asp Pro Phe Ile Leu  Ser Leu Pro 
    1310                 1315                 1320             


Pro Ser  Ser Cys Met Ser Gly  Leu Met Tyr Lys Tyr  Pro Ser Cys 
    1325                 1330                 1335             


Glu Ser  Val Thr Asp Glu Tyr  Ala Gly His Leu Ile  Gln Ile Leu 
    1340                 1345                 1350             


Lys Gln  Glu Gly Gly Asn Ser  Glu Leu Ile Met Asp  Gln Tyr Ala 
    1355                 1360                 1365             


Asn Arg  Leu Ala Tyr Arg Ser  Val Lys Ser Gly Leu  Gln Glu Ala 
    1370                 1375                 1380             


Ala Lys  Thr Thr Lys Val Gln  Cys Asn Ser Arg Met  Phe Pro Val 
    1385                 1390                 1395             


Pro Ser  Ser Gln Val Lys Thr  Asn Lys Glu Leu Leu  Met Phe Ser 
    1400                 1405                 1410             


Asn Lys  Glu His His Gln Glu  Ala Asp Lys Lys Arg  Gln Ser Lys 
    1415                 1420                 1425             


Arg Asn  Glu Gly Tyr Phe Cys  Lys Asn Gln Thr Cys  Glu Arg Thr 
    1430                 1435                 1440             


Leu Asp  Pro Tyr Arg Asn Glu  Val Ser Gln Leu Tyr  Ser Phe Ser 
    1445                 1450                 1455             


Thr Ser  Leu Val His Ser Ile  Thr Lys Asp Ala Lys  Glu Glu Leu 
    1460                 1465                 1470             


Thr Ala  Ser Leu Val Gly Leu  Pro Lys Ser Leu Thr  Asp Ser Cys 
    1475                 1480                 1485             


Leu Phe  Glu Lys Ser Gly Tyr  Glu Glu Asp Asn Glu  Cys His Val 
    1490                 1495                 1500             


Thr Pro  Glu Leu Pro Lys Ser  Leu Gln Pro Ser Ser  Gln Asn His 
    1505                 1510                 1515             


Arg Phe  Tyr His Ser Thr Gly  Ser Leu Asn Gly Tyr  Gly Cys Gly 
    1520                 1525                 1530             


Asp Asn  Val Val Gln Ala Val  Glu Gln Tyr Ala Lys  Lys Val Val 
    1535                 1540                 1545             


Asp Asp  Thr Leu Glu Leu Thr  Leu Gly Ser Thr Val  Phe Arg Val 
    1550                 1555                 1560             


Ser Glu  Thr Thr Lys Ser Ala  Asp Arg Val Thr Tyr  Ala Glu Lys 
    1565                 1570                 1575             


Leu Ser  Pro Leu Thr Gly Gln  Ala Cys Arg Tyr Cys  Asp Leu Lys 
    1580                 1585                 1590             


Glu Leu  His Asn Cys Thr Gly  Asn Ser Ser Gln His  Phe Phe Arg 
    1595                 1600                 1605             


Gln Gly  Ser Leu Ala Ser Ser  Lys Pro Ala Ser Asn  Pro Lys Phe 
    1610                 1615                 1620             


Ser Ser  Arg Tyr Gln Lys Ser  Arg Ile Phe His Leu  Ser Val Pro 
    1625                 1630                 1635             


Gln Ile  His Val Asn Leu Asp  Lys Lys Ala Val Leu  Ala Glu Lys 
    1640                 1645                 1650             

<210>  2995
<211>  5054
<212>  DNA
<213>  Homo sapiens

<400>  2995
agcttgcttg cccggctcgc tcacgggtcg ttgaggccgg tgacatgtct gtgagctgcg     60

gaggctgcgg cccccagatc tttctctttg acactttgca ataaaaaagg gcagtgagat    120

tgaataggtg ttttgtggat taactcttca ttgattatat acaacaaaaa atagttatgg    180

cgactttcag aaacaatcac atgaagacta aagcatctgt cagaaaaagc ttcagtgaag    240

atgtgttcca gtctgtaaag tctttattgc agagtcagaa ggaactatgc agtgtaacag    300

cagaggactg tttacagcag gatgagcatg ccaatttaac tgaggtcaca tttctgggtt    360

ttaatgaaga gacagatgct gctcatatac aggatttagc tgcagtttct ttggaacttc    420

cagatattct gaattcactc cacttctgca gtctaaatga aaatgaaatt atttgtatga    480

agaatataaa taaaccatta gatataagca gtgatcctct aaatcagagt catccttctg    540

gaatgctttg tgtcatgaga gtgtcaccta catcaccaag acttaggatt gattttatct    600

ttagtctcct aagtaaatat gctactggta taaggtacac cttggacaca ttcttgcatc    660

agaagcacca acttgagacc actgatgaag atgatgatga tactaaccag tctgtgtcat    720

ccatagagga tgactttgtc actgcttttg agcacttaga agaggaagag acttcaaagc    780

catacaatga tggaatgaac attactgtgc taaggagcca gtgtgatgct gcttcccaga    840

cggttactgg tcatcattta gaaacccatg atttaaagat tctcattagc tctggacagc    900

agaagtcatt ggctaaaccc tcaacttcct cagtgaatgt cctgggacat aaagaactac    960

cttctgtgaa aacttcagtc acaacatcaa tttcagagcc ttggacccaa aggagtttct   1020

ataggtcatc taatgcttca gataaagata gtgatttaca gaaaacattt ttttcgtctt   1080

ctcctgccta ctcatctgaa tcagaatgtt caagtccaag tcctgttatt ttcttggatg   1140

aagagggata tcaaaaaagc ttaaaagcaa aacttgagct gcctaaaatt cctgtgatga   1200

aagatgatat agaggattca gactcagaag taagtgaatt ttttgatagt tttgatcagt   1260

ttgatgaact agaacaaact ttagagactt gcctgtttaa caaagatccc gtcataggga   1320

agtcatcgca gaggaaaggg cacaaacatg gaaagtcatg tatgaatcct caaaaattca   1380

agtttgatcg tccagctctc ccagctaatg ttagaaagcc aactcctcgt aaaccagaat   1440

ctccatatgg taacctgtgt gatgctccgg attctcctcg cccagtgaag gcatcaaggg   1500

aagatagtgg tttatttagt cctattcgat cctctgcttt tagtcctctt ggaggctgta   1560

ctccagctga atgtttttgc caaacagata ttggtggaga taggattcat gaaaatcatg   1620

attctgttta ttacacctat gaagactatg caaaaagcat ttcatgtgaa gtactaggct   1680

cagttcttcg tacccaccat actaataccc tatcaaatat taacagtatt aaacatggag   1740

aaaataaaac tgtaactttt aagcatggaa accttgatca aaaaaataaa tctaaaaata   1800

aatccttaat gattaaagat agcattcaaa aatttgcagc agatcttgtg gaaaaaagtt   1860

ttggcagtgc atttaaagac ttacagaaag gagtctcttc atgtaccaat gctttgtacc   1920

acttagccat caaattgaca tcatctgttt tgcagatggc atttgatgag ctgagaaggc   1980

agcgtgcatt ttcactaaaa gaacgtgcca ttagtggcct ggctaacttt ttggtgagtg   2040

aagctttatc aaatgcctta aaagatttac agtatgtaaa gaagcagata ttcacaaaca   2100

cagttgctag gtttgctgca gatcttgctg aagagcttgt ttttgaaggc atcatggagg   2160

tgtgtcagtt ttcatatcct caaacgcctg catctccaca gtgtgggtcg tttgactttg   2220

aagacaaagt agtgaagttg tatgcaaaag atttgtctga atctgtaata caggaagcat   2280

tcattgagct atcacaagtt gatgtgacct ttacaacaaa ggcagcagtt agtgtctcta   2340

cggataatat caagtatgtg agtgcagaaa gtgtagtgcc atcgacacag gctgtcacgt   2400

tttccccttc ttttcacaat caagcaatta tggtgacaaa accagtgcag gaatataaaa   2460

aggaatacac agtgcagcag gccttgtttt gtacttctgg aattgttact tctataccgg   2520

tgcccttggc aggaagtgcc cttctcccat atcatatttc atctactgca tgtcaggcca   2580

aggctcatct gtcatctgat gatagtaatt caaatggtga ttctgcccaa gtgcatattg   2640

ccacaaaaaa cagagaagaa aaagcagctt gtctcagaaa tatttgttta ccttcagaac   2700

acaatccagg taatcagaat gattttaaac caactaatga cgatattgaa atgcagagtt   2760

cctcaaaatt accaaatgat cctgcaatta ttagcaactt ttctgcagca gtggtgcata   2820

cgatagtaaa tgaaacttta gagtcaatga catcattgga agttacaaaa atggttgatg   2880

aacgtacaga ttatttaact aaatctttaa aggagaaaac ccctccattt tcccactgtg   2940

atcaggcagt gctgcaatgc agtgaagcta gtagcaataa ggacatgttt gctgaccggt   3000

tatctaaatc tattattaaa cattccatag ataagagcaa atcagtgatc ccaaatatag   3060

ataaaaatgc agtatacaag gaaagcttgc ctgtttctgg agaagaatca cagttgacac   3120

cagaaaagtc tcccaaattt cctgactctc agaatcagtt aactcactgc tcactttcag   3180

ctgcaaagga ttgtgttcca gaatgtaaag tttctatggt tcatggatcc tccctagaga   3240

cactgccatc ttgtccagct gtgacaggtc agaaatctga cttgaaggaa tctgctaagg   3300

atcaaccact gaaaaagcat aacttgaata gtacatcact tgaggccttg tcttttggac   3360

aggaaaaccc ctttcctcat tcacatactt tctcatctac agcacttacc tgtgtagatg   3420

gtttgcatgt ggaagataaa cagaaagtca gagacagaaa tgtaatacct gatactcctc   3480

catcaactcc tctagtacca tcccgggcta gttctgaatg ggatatcaag aagttaacta   3540

aaaagctcaa gggagaatta gccaaagagt ttgcacctgc tacaccacct tctactccac   3600

acaactcatc tgttggtagt ttgtctgaga atgaacaaaa tactatagaa aaagaagagt   3660

tcatgttgaa actcatgcga tctctttctg aagaagttga gagtagtgaa agtggagagc   3720

tcccagaagt ggatgtgaag tcggagcact cagggaagaa ggttcagttt gcagaagcat   3780

tagctacaca catcctttct cttgcaactg aaatggcagc ttcccattta gataacaaaa   3840

taattcaaga acccaaggtt aaaaaccctt gcttaaatgt gcaaagtcaa agaagtgtgt   3900

cgcctacttt tttaaacccc tcagacgaaa atttgaaaac attatgcaat tttgcgggtg   3960

atctggcagc agaagtcatt acagaagctg agaaaatagc aaaagtccga aattgtatgc   4020

ttttcaagca aaagaagaac agttgttatg ctgatggtga cgaagattat aaagtagaag   4080

agaagttgga tatagaggct gtagtgcacc caagagaagt ggatccgttt attctttcat   4140

taccaccaag ttcttgtatg tcaggtctga tgtataagta tcccagctgt gaaagtgtga   4200

cagatgaata tgcaggtcac cttattcaga tactaaaaca ggaaggtggt aatagtgagt   4260

tgataatgga tcagtatgcc aataggcttg cctaccgatc tgttaaatca ggattacagg   4320

aagcagctaa gacaaccaaa gtgcagtgca actcaagaat gttccctgtg ccaagttcac   4380

aagtgaaaac aaacaaggaa ctgttaatgt tttcaaacaa agagcaccac caagaagcag   4440

acaaaaagag acaaagtaaa agaaatgaag gttacttttg taaaaatcaa acttgtgaaa   4500

ggaccctgtg gaccatcagt tgaacttagc ccctggaaat ggcaaactag gtgtgggagg   4560

gaaggcaact cttggaaaag ggaatgaggt agcataagga aaggaaatgg cttttcacct   4620

gatagaacac ttcatctcga agagttttgt tcgatgcttg gattaacctg gaaatattaa   4680

tatttttgta aagtatattt tgtcatagtt tattatggtg ctatataaac caccaatatt   4740

tcttaaaatc taggtccaaa aagacagtgt ttaaaactgg tagaagcaag tgggggcaat   4800

gtcacaaatc atgatttggc ccttttctat aactttatct agaaaaggat actaacattt   4860

agtttcttct ctcattttga gaaacacagg cttctatgtg gcattaaggt tctggcacag   4920

agaaaaagcg gggctcatcc aggattggta tattgattta caagatatgt tgcatctgtt   4980

gatgacaatt gatatctata ctgttctttt ctgctacaga gatcaaggta ggagataaag   5040

acttcggcga tttg                                                     5054


<210>  2996
<211>  1448
<212>  PRT
<213>  Homo sapiens

<400>  2996


Met Ala Thr Phe Arg Asn Asn His Met Lys Thr Lys Ala Ser Val Arg 
1               5                   10                  15      


Lys Ser Phe Ser Glu Asp Val Phe Gln Ser Val Lys Ser Leu Leu Gln 
            20                  25                  30          


Ser Gln Lys Glu Leu Cys Ser Val Thr Ala Glu Asp Cys Leu Gln Gln 
        35                  40                  45              


Asp Glu His Ala Asn Leu Thr Glu Val Thr Phe Leu Gly Phe Asn Glu 
    50                  55                  60                  


Glu Thr Asp Ala Ala His Ile Gln Asp Leu Ala Ala Val Ser Leu Glu 
65                  70                  75                  80  


Leu Pro Asp Ile Leu Asn Ser Leu His Phe Cys Ser Leu Asn Glu Asn 
                85                  90                  95      


Glu Ile Ile Cys Met Lys Asn Ile Asn Lys Pro Leu Asp Ile Ser Ser 
            100                 105                 110         


Asp Pro Leu Asn Gln Ser His Pro Ser Gly Met Leu Cys Val Met Arg 
        115                 120                 125             


Val Ser Pro Thr Ser Pro Arg Leu Arg Ile Asp Phe Ile Phe Ser Leu 
    130                 135                 140                 


Leu Ser Lys Tyr Ala Thr Gly Ile Arg Tyr Thr Leu Asp Thr Phe Leu 
145                 150                 155                 160 


His Gln Lys His Gln Leu Glu Thr Thr Asp Glu Asp Asp Asp Asp Thr 
                165                 170                 175     


Asn Gln Ser Val Ser Ser Ile Glu Asp Asp Phe Val Thr Ala Phe Glu 
            180                 185                 190         


His Leu Glu Glu Glu Glu Thr Ser Lys Pro Tyr Asn Asp Gly Met Asn 
        195                 200                 205             


Ile Thr Val Leu Arg Ser Gln Cys Asp Ala Ala Ser Gln Thr Val Thr 
    210                 215                 220                 


Gly His His Leu Glu Thr His Asp Leu Lys Ile Leu Ile Ser Ser Gly 
225                 230                 235                 240 


Gln Gln Lys Ser Leu Ala Lys Pro Ser Thr Ser Ser Val Asn Val Leu 
                245                 250                 255     


Gly His Lys Glu Leu Pro Ser Val Lys Thr Ser Val Thr Thr Ser Ile 
            260                 265                 270         


Ser Glu Pro Trp Thr Gln Arg Ser Phe Tyr Arg Ser Ser Asn Ala Ser 
        275                 280                 285             


Asp Lys Asp Ser Asp Leu Gln Lys Thr Phe Phe Ser Ser Ser Pro Ala 
    290                 295                 300                 


Tyr Ser Ser Glu Ser Glu Cys Ser Ser Pro Ser Pro Val Ile Phe Leu 
305                 310                 315                 320 


Asp Glu Glu Gly Tyr Gln Lys Ser Leu Lys Ala Lys Leu Glu Leu Pro 
                325                 330                 335     


Lys Ile Pro Val Met Lys Asp Asp Ile Glu Asp Ser Asp Ser Glu Val 
            340                 345                 350         


Ser Glu Phe Phe Asp Ser Phe Asp Gln Phe Asp Glu Leu Glu Gln Thr 
        355                 360                 365             


Leu Glu Thr Cys Leu Phe Asn Lys Asp Pro Val Ile Gly Lys Ser Ser 
    370                 375                 380                 


Gln Arg Lys Gly His Lys His Gly Lys Ser Cys Met Asn Pro Gln Lys 
385                 390                 395                 400 


Phe Lys Phe Asp Arg Pro Ala Leu Pro Ala Asn Val Arg Lys Pro Thr 
                405                 410                 415     


Pro Arg Lys Pro Glu Ser Pro Tyr Gly Asn Leu Cys Asp Ala Pro Asp 
            420                 425                 430         


Ser Pro Arg Pro Val Lys Ala Ser Arg Glu Asp Ser Gly Leu Phe Ser 
        435                 440                 445             


Pro Ile Arg Ser Ser Ala Phe Ser Pro Leu Gly Gly Cys Thr Pro Ala 
    450                 455                 460                 


Glu Cys Phe Cys Gln Thr Asp Ile Gly Gly Asp Arg Ile His Glu Asn 
465                 470                 475                 480 


His Asp Ser Val Tyr Tyr Thr Tyr Glu Asp Tyr Ala Lys Ser Ile Ser 
                485                 490                 495     


Cys Glu Val Leu Gly Ser Val Leu Arg Thr His His Thr Asn Thr Leu 
            500                 505                 510         


Ser Asn Ile Asn Ser Ile Lys His Gly Glu Asn Lys Thr Val Thr Phe 
        515                 520                 525             


Lys His Gly Asn Leu Asp Gln Lys Asn Lys Ser Lys Asn Lys Ser Leu 
    530                 535                 540                 


Met Ile Lys Asp Ser Ile Gln Lys Phe Ala Ala Asp Leu Val Glu Lys 
545                 550                 555                 560 


Ser Phe Gly Ser Ala Phe Lys Asp Leu Gln Lys Gly Val Ser Ser Cys 
                565                 570                 575     


Thr Asn Ala Leu Tyr His Leu Ala Ile Lys Leu Thr Ser Ser Val Leu 
            580                 585                 590         


Gln Met Ala Phe Asp Glu Leu Arg Arg Gln Arg Ala Phe Ser Leu Lys 
        595                 600                 605             


Glu Arg Ala Ile Ser Gly Leu Ala Asn Phe Leu Val Ser Glu Ala Leu 
    610                 615                 620                 


Ser Asn Ala Leu Lys Asp Leu Gln Tyr Val Lys Lys Gln Ile Phe Thr 
625                 630                 635                 640 


Asn Thr Val Ala Arg Phe Ala Ala Asp Leu Ala Glu Glu Leu Val Phe 
                645                 650                 655     


Glu Gly Ile Met Glu Val Cys Gln Phe Ser Tyr Pro Gln Thr Pro Ala 
            660                 665                 670         


Ser Pro Gln Cys Gly Ser Phe Asp Phe Glu Asp Lys Val Val Lys Leu 
        675                 680                 685             


Tyr Ala Lys Asp Leu Ser Glu Ser Val Ile Gln Glu Ala Phe Ile Glu 
    690                 695                 700                 


Leu Ser Gln Val Asp Val Thr Phe Thr Thr Lys Ala Ala Val Ser Val 
705                 710                 715                 720 


Ser Thr Asp Asn Ile Lys Tyr Val Ser Ala Glu Ser Val Val Pro Ser 
                725                 730                 735     


Thr Gln Ala Val Thr Phe Ser Pro Ser Phe His Asn Gln Ala Ile Met 
            740                 745                 750         


Val Thr Lys Pro Val Gln Glu Tyr Lys Lys Glu Tyr Thr Val Gln Gln 
        755                 760                 765             


Ala Leu Phe Cys Thr Ser Gly Ile Val Thr Ser Ile Pro Val Pro Leu 
    770                 775                 780                 


Ala Gly Ser Ala Leu Leu Pro Tyr His Ile Ser Ser Thr Ala Cys Gln 
785                 790                 795                 800 


Ala Lys Ala His Leu Ser Ser Asp Asp Ser Asn Ser Asn Gly Asp Ser 
                805                 810                 815     


Ala Gln Val His Ile Ala Thr Lys Asn Arg Glu Glu Lys Ala Ala Cys 
            820                 825                 830         


Leu Arg Asn Ile Cys Leu Pro Ser Glu His Asn Pro Gly Asn Gln Asn 
        835                 840                 845             


Asp Phe Lys Pro Thr Asn Asp Asp Ile Glu Met Gln Ser Ser Ser Lys 
    850                 855                 860                 


Leu Pro Asn Asp Pro Ala Ile Ile Ser Asn Phe Ser Ala Ala Val Val 
865                 870                 875                 880 


His Thr Ile Val Asn Glu Thr Leu Glu Ser Met Thr Ser Leu Glu Val 
                885                 890                 895     


Thr Lys Met Val Asp Glu Arg Thr Asp Tyr Leu Thr Lys Ser Leu Lys 
            900                 905                 910         


Glu Lys Thr Pro Pro Phe Ser His Cys Asp Gln Ala Val Leu Gln Cys 
        915                 920                 925             


Ser Glu Ala Ser Ser Asn Lys Asp Met Phe Ala Asp Arg Leu Ser Lys 
    930                 935                 940                 


Ser Ile Ile Lys His Ser Ile Asp Lys Ser Lys Ser Val Ile Pro Asn 
945                 950                 955                 960 


Ile Asp Lys Asn Ala Val Tyr Lys Glu Ser Leu Pro Val Ser Gly Glu 
                965                 970                 975     


Glu Ser Gln Leu Thr Pro Glu Lys Ser Pro Lys Phe Pro Asp Ser Gln 
            980                 985                 990         


Asn Gln Leu Thr His Cys Ser Leu  Ser Ala Ala Lys Asp  Cys Val Pro 
        995                 1000                 1005             


Glu Cys  Lys Val Ser Met Val  His Gly Ser Ser Leu  Glu Thr Leu 
    1010                 1015                 1020             


Pro Ser  Cys Pro Ala Val Thr  Gly Gln Lys Ser Asp  Leu Lys Glu 
    1025                 1030                 1035             


Ser Ala  Lys Asp Gln Pro Leu  Lys Lys His Asn Leu  Asn Ser Thr 
    1040                 1045                 1050             


Ser Leu  Glu Ala Leu Ser Phe  Gly Gln Glu Asn Pro  Phe Pro His 
    1055                 1060                 1065             


Ser His  Thr Phe Ser Ser Thr  Ala Leu Thr Cys Val  Asp Gly Leu 
    1070                 1075                 1080             


His Val  Glu Asp Lys Gln Lys  Val Arg Asp Arg Asn  Val Ile Pro 
    1085                 1090                 1095             


Asp Thr  Pro Pro Ser Thr Pro  Leu Val Pro Ser Arg  Ala Ser Ser 
    1100                 1105                 1110             


Glu Trp  Asp Ile Lys Lys Leu  Thr Lys Lys Leu Lys  Gly Glu Leu 
    1115                 1120                 1125             


Ala Lys  Glu Phe Ala Pro Ala  Thr Pro Pro Ser Thr  Pro His Asn 
    1130                 1135                 1140             


Ser Ser  Val Gly Ser Leu Ser  Glu Asn Glu Gln Asn  Thr Ile Glu 
    1145                 1150                 1155             


Lys Glu  Glu Phe Met Leu Lys  Leu Met Arg Ser Leu  Ser Glu Glu 
    1160                 1165                 1170             


Val Glu  Ser Ser Glu Ser Gly  Glu Leu Pro Glu Val  Asp Val Lys 
    1175                 1180                 1185             


Ser Glu  His Ser Gly Lys Lys  Val Gln Phe Ala Glu  Ala Leu Ala 
    1190                 1195                 1200             


Thr His  Ile Leu Ser Leu Ala  Thr Glu Met Ala Ala  Ser His Leu 
    1205                 1210                 1215             


Asp Asn  Lys Ile Ile Gln Glu  Pro Lys Val Lys Asn  Pro Cys Leu 
    1220                 1225                 1230             


Asn Val  Gln Ser Gln Arg Ser  Val Ser Pro Thr Phe  Leu Asn Pro 
    1235                 1240                 1245             


Ser Asp  Glu Asn Leu Lys Thr  Leu Cys Asn Phe Ala  Gly Asp Leu 
    1250                 1255                 1260             


Ala Ala  Glu Val Ile Thr Glu  Ala Glu Lys Ile Ala  Lys Val Arg 
    1265                 1270                 1275             


Asn Cys  Met Leu Phe Lys Gln  Lys Lys Asn Ser Cys  Tyr Ala Asp 
    1280                 1285                 1290             


Gly Asp  Glu Asp Tyr Lys Val  Glu Glu Lys Leu Asp  Ile Glu Ala 
    1295                 1300                 1305             


Val Val  His Pro Arg Glu Val  Asp Pro Phe Ile Leu  Ser Leu Pro 
    1310                 1315                 1320             


Pro Ser  Ser Cys Met Ser Gly  Leu Met Tyr Lys Tyr  Pro Ser Cys 
    1325                 1330                 1335             


Glu Ser  Val Thr Asp Glu Tyr  Ala Gly His Leu Ile  Gln Ile Leu 
    1340                 1345                 1350             


Lys Gln  Glu Gly Gly Asn Ser  Glu Leu Ile Met Asp  Gln Tyr Ala 
    1355                 1360                 1365             


Asn Arg  Leu Ala Tyr Arg Ser  Val Lys Ser Gly Leu  Gln Glu Ala 
    1370                 1375                 1380             


Ala Lys  Thr Thr Lys Val Gln  Cys Asn Ser Arg Met  Phe Pro Val 
    1385                 1390                 1395             


Pro Ser  Ser Gln Val Lys Thr  Asn Lys Glu Leu Leu  Met Phe Ser 
    1400                 1405                 1410             


Asn Lys  Glu His His Gln Glu  Ala Asp Lys Lys Arg  Gln Ser Lys 
    1415                 1420                 1425             


Arg Asn  Glu Gly Tyr Phe Cys  Lys Asn Gln Thr Cys  Glu Arg Thr 
    1430                 1435                 1440             


Leu Trp  Thr Ile Ser 
    1445             

<210>  2997
<211>  9922
<212>  DNA
<213>  Homo sapiens

<400>  2997
agcttgcttg cccggctcgc tcacgggtcg ttgaggccgg tgacatgtct gtgagctgcg     60

gaggctgcgg cccccagatc tttctctttg acactttgca ataaaaaagg gcagtgagat    120

tgaataggtg ttttgtggat taactcttca ttgattatat acaacaaaaa atagttatgg    180

cgactttcag aaacaatcac atgaagacta aagcatctgt cagaaaaagc ttcagtgaag    240

atgtgttcca gtctgtaaag tctttattgc agagtcagaa ggaactatgc agtgtaacag    300

cagaggactg tttacagcag gatgagcatg ccaatttaac tgaggtcaca tttctgggtt    360

ttaatgaaga gacagatgct gctcatatac aggatttagc tgcagtttct ttggaacttc    420

cagatattct gaattcactc cacttctgca gtctaaatga aaatgaaatt atttgtatga    480

agaatataaa taaaccatta gatataagca gtgatcctct aaatcagagt catccttctg    540

gaatgctttg tgtcatgaga gtgtcaccta catcaccaag acttaggatt gattttatct    600

ttagtctcct aagtaaatat gctactggta taaggtacac cttggacaca ttcttgcatc    660

agaagcacca acttgagacc actgatgaag atgatgatga tactaaccag tctgtgtcat    720

ccatagagga tgactttgtc actgcttttg agcacttaga agaggaagag acttcaaagc    780

catacaatga tggaatgaac attactgtgc taaggagcca gtgtgatgct gcttcccaga    840

cggttactgg tcatcattta gaaacccatg atttaaagat tctcattagc tctggacagc    900

agaagtcatt ggctaaaccc tcaacttcct cagtgaatgt cctgggacat aaagaactac    960

cttctgtgaa aacttcagtc acaacatcaa tttcagagcc ttggacccaa aggagtttct   1020

ataggtcatc taatgcttca gataaagata gtgatttaca gaaaacattt ttttcgtctt   1080

ctcctgccta ctcatctgaa tcagaatgtt caagtccaag tcctgttatt ttcttggatg   1140

aagagggata tcaaaaaagc ttaaaagcaa aacttgagct gcctaaaatt cctgtgatga   1200

aagatgatat agaggattca gactcagaag taagtgaatt ttttgatagt tttgatcagt   1260

ttgatgaact agaacaaact ttagagactt gcctgtttaa caaagatccc gtcataggga   1320

agtcatcgca gaggaaaggg cacaaacatg gaaagtcatg tatgaatcct caaaaattca   1380

agtttgatcg tccagctctc ccagctaatg ttagaaagcc aactcctcgt aaaccagaat   1440

ctccatatgg taacctgtgt gatgctccgg attctcctcg cccagtgaag gcatcaaggg   1500

aagatagtgg tttatttagt cctattcgat cctctgcttt tagtcctctt ggaggctgta   1560

ctccagctga atgtttttgc caaacagata ttggtggaga taggattcat gaaaatcatg   1620

attctgttta ttacacctat gaagactatg caaaaagcat ttcatgtgaa gtactaggct   1680

cagttcttcg tacccaccat actaataccc tatcaaatat taacagtatt aaacatggag   1740

aaaataaaac tgtaactttt aagcatggaa accttgatca aaaaaataaa tctaaaaata   1800

aatccttaat gattaaagat agcattcaaa aatttgcagc agatcttgtg gaaaaaagtt   1860

ttggcagtgc atttaaagac ttacagaaag gagtctcttc atgtaccaat gctttgtacc   1920

acttagccat caaattgaca tcatctgttt tgcagatggc atttgatgag ctgagaaggc   1980

agcgtgcatt ttcactaaaa gaacgtgcca ttagtggcct ggctaacttt ttggtgagtg   2040

aagctttatc aaatgcctta aaagatttac agtatgtaaa gaagcagata ttcacaaaca   2100

cagttgctag gtttgctgca gatcttgctg aagagcttgt ttttgaaggc atcatggagg   2160

tgtgtcagtt ttcatatcct caaacgcctg catctccaca gtgtgggtcg tttgactttg   2220

aagacaaagt agtgaagttg tatgcaaaag atttgtctga atctgtaata caggaagcat   2280

tcattgagct atcacaagtt gatgtgacct ttacaacaaa ggcagcagtt agtgtctcta   2340

cggataatat caagtatgtg agtgcagaaa gtgtagtgcc atcgacacag gctgtcacgt   2400

tttccccttc ttttcacaat caagcaatta tggtgacaaa accagtgcag gaatataaaa   2460

aggaatacac agtgcagcag gccttgtttt gtacttctgg aattgttact tctataccgg   2520

tgcccttggc aggaagtgcc cttctcccat atcatatttc atctactgca tgtcaggcca   2580

aggctcatct gtcatctgat gatagtaatt caaatggtga ttctgcccaa gtgcatattg   2640

ccacaaaaaa cagagaagaa aaagcagctt gtctcagaaa tatttgttta ccttcagaac   2700

acaatccagg taatcagaat gattttaaac caactaatga cgatattgaa atgcagagtt   2760

cctcaaaatt accaaatgat cctgcaatta ttagcaactt ttctgcagca gtggtgcata   2820

cgatagtaaa tgaaacttta gagtcaatga catcattgga agttacaaaa atggttgatg   2880

aacgtacaga ttatttaact aaatctttaa aggagaaaac ccctccattt tcccactgtg   2940

atcaggcagt gctgcaatgc agtgaagcta gtagcaataa ggacatgttt gctgaccggt   3000

tatctaaatc tattattaaa cattccatag ataagagcaa atcagtgatc ccaaatatag   3060

ataaaaatgc agtatacaag gaaagcttgc ctgtttctgg agaagaatca cagttgacac   3120

cagaaaagtc tcccaaattt cctgactctc agaatcagtt aactcactgc tcactttcag   3180

ctgcaaagga ttgtgttcca gaatgtaaag tttctatggt tcatggatcc tccctagaga   3240

cactgccatc ttgtccagct gtgacaggtc agaaatctga cttgaaggaa tctgctaagg   3300

atcaaccact gaaaaagcat aacttgaata gtacatcact tgaggccttg tcttttggac   3360

aggaaaaccc ctttcctcat tcacatactt tctcatctac agcacttacc tgtgtagatg   3420

gtttgcatgt ggaagataaa cagaaagtca gagacagaaa tgtaatacct gatactcctc   3480

catcaactcc tctagtacca tcccgggcta gttctgaatg ggatatcaag aagttaacta   3540

aaaagctcaa gggagaatta gccaaagagt ttgcacctgc tacaccacct tctactccac   3600

acaactcatc tgttggtagt ttgtctgaga atgaacaaaa tactatagaa aaagaagagt   3660

tcatgttgaa actcatgcga tctctttctg aagaagttga gagtagtgaa agtggagagc   3720

tcccagaagt ggatgtgaag tcggagcact cagggaagaa ggttcagttt gcagaagcat   3780

tagctacaca catcctttct cttgcaactg aaatggcagc ttcccattta gataacaaaa   3840

taattcaaga acccaaggtt aaaaaccctt gcttaaatgt gcaaagtcaa agaagtgtgt   3900

cgcctacttt tttaaacccc tcagacgaaa atttgaaaac attatgcaat tttgcgggtg   3960

atctggcagc agaagtcatt acagaagctg agaaaatagc aaaagtccga aattgtatgc   4020

ttttcaagca aaagaagaac agttgttatg ctgatggtga cgaagattat aaagtagaag   4080

agaagttgga tatagaggct gtagtgcacc caagagaagt ggatccgttt attctttcat   4140

taccaccaag ttcttgtatg tcaggtctga tgtataagta tcccagctgt gaaagtgtga   4200

cagatgaata tgcaggtcac cttattcaga tactaaaaca ggaaggtggt aatagtgagt   4260

tgataatgga tcagtatgcc aataggcttg cctaccgatc tgttaaatca ggattacagg   4320

aagcagctaa gacaaccaaa gtgcagtgca actcaagaat gttccctgtg ccaagttcac   4380

aagtgaaaac aaacaaggaa ctgttaatgt tttcaaacaa agagcaccac caagaagcag   4440

acaaaaagag acaaagtaaa agaaatgaag gttacttttg taaaaatcaa acttgtgaaa   4500

ggaccctgga tccatataga aatgaggtct cccaactgta tagtttttca acctctctgg   4560

ttcacagcat aacaaaagat gctaaggaag agttgacagc ctctctagtt ggcctaccaa   4620

aatccttaac agattcttgc ttgtttgaaa aatctggata tgaagaagat aatgagtgtc   4680

acgttacacc agaattgcct aagtctcttc agccttcctc acaaaatcac aggttttacc   4740

acagcactgg cagtttaaat ggatatggtt gtggagacaa tgttgttcaa gctgtagaac   4800

agtatgccaa aaaagtagtg gatgacactc tagagctaac tctaggatct acagtgttcc   4860

gagtgtctga gaccacaaaa tcagcagaca gggtcactta tgcagaaaag ttgtcacctc   4920

ttacaggtca agcttgcaga tactgtgacc ttaaagaact ccacaattgc actggaaatt   4980

catctcagca ctttttcaga cagggttctc tcgccagtag taagccagct tctaatccaa   5040

aatttagcag ccgctatcag aaatctagga tttttcatct cagtgtccct cagattcatg   5100

ttaatcttga taagaaggca gtgcttgctg agaagatagt tgctgaagcc attgaaaaag   5160

ctgagcgaga gctgagcagt accagcctgg cagccgacag tgggatcgga caggagggtg   5220

ccagctttgc tgaaagcctt gccacagaaa ccatgacagc agctgtcaca aatgttgggc   5280

atgctgttag cagttcaaaa gaaatagaag actttcagtc aaccgagtct gtcagtagcc   5340

agcagatgaa cctcagtatt ggtgatgaca gcactggtag ctggtccaat ttaagttttg   5400

aagatgaaca ccaagatgaa agcagcagtt ttcatcatct aagtgaaagt aatggtaaca   5460

gcagtagctg gagcagtctt ggtttagaag gagatttgta tgaggacaat ttatcctttc   5520

caacatcaga cagtgatgga ccagatgata aagatgaaga gcatgaggac gaagtagaag   5580

gtttggggca agatggaaag acactgctaa ttacgaatat tgacatggag ccatgcacgg   5640

tagaccccca gctaaggatt attcttcagt ggctcattgc ctctgaggct gaagttgcag   5700

aactttattt tcatgactct gcaaataagg agtttatgct actttcaaaa caattacaag   5760

agaaaggatg gaaagtggga gacctcctgc aggctgtgct tcaatactat gaagtgatgg   5820

aaaaagcttc cagtgaggag agatgcaagt cgctgtttga ttggctcttg gaaaatgcat   5880

agagcaaacc ccaaaccagt atattttagt atttgtttgg ggaggggaac aagccaataa   5940

agatgtttag gataaaattt gaatagtgaa tattaacatc gtaagtcagt tgggaggcaa   6000

gtaaatatag ctttctgagc gctttgtgtt atcactcggt gtatatagtt catacttttg   6060

taatctgtca aaatactacc ttcatttatt cttctataca catgtgtagt gtgtcaagac   6120

cctaagaaca tgtatttgaa ggaaggtcta accagggggt tttcaggggc attgtctgac   6180

cacattcttt ttgtatccaa atagtgctgc tagaaactgc actgaagtgg ctgaggatag   6240

gttccagtga tagagttata attttgctcc tttgcaaaca aatggtatct aattaataac   6300

tagtctgaca tcagaaaata aaattgaggc tgatttttaa aaatttctag tagatttttg   6360

gcctttcctg tttttaaaaa tcagtttcat tttcatattt catagatcag ctattggtag   6420

ctttttgatt tccccaaact atttaatttc ttagcagaaa cattagtatt ttaggtttct   6480

ataaacacta taagtgatag tttcccccat cctttcattg acattatttg ccaatgctgc   6540

cagtcattct ggcatgaaag gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt   6600

gtgtaaggga gtactttaac cttgccagtt tgttccctct tttattttac tgttttcttt   6660

ttagaaaccc actgttaaaa tttaaaaagg tgctttaaaa taaaacgcct ataaagattg   6720

tgcagtaaga atttttattg acaataatta aaattttttt tgacaatttt gggttcccaa   6780

cttatcttac aagtgaaaac ttaaattgta aaacatgttg aaattttaaa aattaatgtt   6840

aatatggaaa tgcatttaga gaagcccagt agtttttatt gttggatttt tgaaaaaacc   6900

tctaccaaga atgtggtgtt ttttttgttt gtttgtttgt ttgttttaga aaaattggga   6960

tttcccccca ccccgcccca cccagataaa ctatatctac actgtctcgt caagttctct   7020

gacacgatct ttctgggctc tacatttcct actagtttgt gtccagaaac tgcaagttga   7080

catgaataga ggacaaaggt tgtgtcttgc ttttgtctct ctcttccctc cctgcaactc   7140

tctctcccct cctcccactc tcttccccct cccccctcct cccactgtct ctcacctccc   7200

ccacccccca ctctctctca tctctcgctg tgtcctgtgt atgtgtgggt gtgtgtgtat   7260

ttgggtgtgt aaatgttggt tcttccacta ctggattttg taatctagga taaatcactt   7320

tttttgggga ctttgatttt gctccattac gttttcattt tttctgagca ctgactgttc   7380

tgaaagctgc acaaaacgta gaaagaagac atagcgcctg ccagggaata ggaaatgagg   7440

gcacttacac attaatgtga attagtaatt gtggtataga aatgttttat agtgaaagat   7500

tcaaatttgc ttttcaagaa aaatgccaaa agctatttaa ataattcgag gttacatcgt   7560

aggttttgat ttttctcaat ttaagataca gaaatacagc aagccttaat ataaagtttc   7620

ctaaagtttc ttcaagtatt ttttaaggtg gagaaatgca ggaattgtat aaccagaatt   7680

gttcctgcct ttagcttttc agaacttgag atgtggcagc actggactgg gtttttttaa   7740

atgttaggac taggaatgtt tgctcttgtt aattatgaat taattgatta ttaagtttag   7800

aatgcatttt tacaagtatc taactatcaa attgtgttta gtaacttgag tgtatgcaca   7860

agtttgatca acagcaaaat agagttctga atttctttta aagtgatgat atattatttt   7920

gtgaaacttt gtgtttgaaa atgtttattt ctgtttatgg tgtaatcatt ctgaggtgag   7980

gcttttctta tttcctttgc attttgctag agctgtgctg agttcagcat ttgcttattt   8040

aaccactaca taatgacaga ccagttatta ggtattagca tgtgtggtaa taataatagt   8100

ggaacttcac acttacatca attcagtgca ggggcataga ataaaatatt aaatattggc   8160

agatgtatga aaagaagtgt gagttaaaaa tattgaatat tggcaggtgt gaaaacaagt   8220

gtcaaaattc ctcatataga gaaaataatt ttgagtttag agtattatct tttaattaag   8280

tgtagtctaa acttaacttt ctgtaaaggc actttgtggt ttttccaaag atgttctaga   8340

tctatttggt tgctctatag tcaaacagct cttttgaaga caactgtctt attttattac   8400

aaattggctt gacatattta tactgtaaca ttgtaatatt gctgtgctgt acattttggc   8460

ccttacgaaa tacgtctttt tcagaactgt taaagttttg atgtacatcg agctgaattc   8520

tgtttttacc agtttcaaaa ccttcaagtg atatgtggaa aaaagtgaat gagacctctg   8580

atagggggtt ttcagaacct tgttcacacc aaaatgtgac agttctttca tgttttccta   8640

aaccaagtta aaattacatg tatattttgg tgttaaggtt gatttttaag atacttctga   8700

tttgtacaaa aggaatgttt cctttataaa tcacagaaga aaatgacaat atctgttgga   8760

tatttgatat aatttaatgg tgttataaaa cctttaagag gattcatggt gaatatatgt   8820

gataacatct ttatactttg aaaaatgttc cacttaccct tcagatattt gttgtaagtt   8880

aattcaattc ttaatacttt aattttgctc caacaagggc tttatgttgc tggtaagaga   8940

atttatttac taaatgcact atgtataaag tgaaagatag tttacttatc tgactttgat   9000

attagatggc tgacattagt gcacataatg cagagtttaa ccttgattct tcaacagagt   9060

ccagatttaa atgtctactt agttaattag ttagctgata ttcttccaca attaatatat   9120

tcaatttccc atcagtatat cactttaaat tttatgtttt tctaaggaaa ctttccacag   9180

aattttaaac aactgatgca tccatactca gggtgtaggg agaatacttt gcatttaaaa   9240

accctgtcca cctgtcacca gcacaagaga attagagctt cagtgagaat ttagaaaaat   9300

tatactaaag tgagatgcat tttttctcat tttcagcaag actcctctaa gcatttactc   9360

atttactgta ttcctgctct gaagatgtgg atacagaatt agtcactctt gtcactttat   9420

ttatttattg gttttttttt aaccatctgt gtacattcct ttcatagggt agagttctag   9480

ttctagaagt tcttattttg tttttgttgt aatgtttgaa tactatttaa tatccggttt   9540

taatattgct ggatttgcta cctttggtta cttgtgcagt gttaaaagta atccactttc   9600

ttgtttaata taccagatac atagcaaaag cagcttggaa taattatagc tgtttatttg   9660

gctgtgctca gttactatat taagatcttg tactgtgtaa cagtaactct tttttgcttt   9720

tcagtaattt aatatgttca cttaacaaaa tacgaacttt gagatgcact aaagttttgt   9780

ttcagcagtg gctcaaaaaa tttcagaaat tacttttgta attatttgca attaattgtt   9840

cttttatctt acaattgttt aagcctgtga tctttcttct cccagctaag agttcttcaa   9900

taaatttaag aaatacctgg tc                                            9922


<210>  2998
<211>  1901
<212>  PRT
<213>  Homo sapiens

<400>  2998


Met Ala Thr Phe Arg Asn Asn His Met Lys Thr Lys Ala Ser Val Arg 
1               5                   10                  15      


Lys Ser Phe Ser Glu Asp Val Phe Gln Ser Val Lys Ser Leu Leu Gln 
            20                  25                  30          


Ser Gln Lys Glu Leu Cys Ser Val Thr Ala Glu Asp Cys Leu Gln Gln 
        35                  40                  45              


Asp Glu His Ala Asn Leu Thr Glu Val Thr Phe Leu Gly Phe Asn Glu 
    50                  55                  60                  


Glu Thr Asp Ala Ala His Ile Gln Asp Leu Ala Ala Val Ser Leu Glu 
65                  70                  75                  80  


Leu Pro Asp Ile Leu Asn Ser Leu His Phe Cys Ser Leu Asn Glu Asn 
                85                  90                  95      


Glu Ile Ile Cys Met Lys Asn Ile Asn Lys Pro Leu Asp Ile Ser Ser 
            100                 105                 110         


Asp Pro Leu Asn Gln Ser His Pro Ser Gly Met Leu Cys Val Met Arg 
        115                 120                 125             


Val Ser Pro Thr Ser Pro Arg Leu Arg Ile Asp Phe Ile Phe Ser Leu 
    130                 135                 140                 


Leu Ser Lys Tyr Ala Thr Gly Ile Arg Tyr Thr Leu Asp Thr Phe Leu 
145                 150                 155                 160 


His Gln Lys His Gln Leu Glu Thr Thr Asp Glu Asp Asp Asp Asp Thr 
                165                 170                 175     


Asn Gln Ser Val Ser Ser Ile Glu Asp Asp Phe Val Thr Ala Phe Glu 
            180                 185                 190         


His Leu Glu Glu Glu Glu Thr Ser Lys Pro Tyr Asn Asp Gly Met Asn 
        195                 200                 205             


Ile Thr Val Leu Arg Ser Gln Cys Asp Ala Ala Ser Gln Thr Val Thr 
    210                 215                 220                 


Gly His His Leu Glu Thr His Asp Leu Lys Ile Leu Ile Ser Ser Gly 
225                 230                 235                 240 


Gln Gln Lys Ser Leu Ala Lys Pro Ser Thr Ser Ser Val Asn Val Leu 
                245                 250                 255     


Gly His Lys Glu Leu Pro Ser Val Lys Thr Ser Val Thr Thr Ser Ile 
            260                 265                 270         


Ser Glu Pro Trp Thr Gln Arg Ser Phe Tyr Arg Ser Ser Asn Ala Ser 
        275                 280                 285             


Asp Lys Asp Ser Asp Leu Gln Lys Thr Phe Phe Ser Ser Ser Pro Ala 
    290                 295                 300                 


Tyr Ser Ser Glu Ser Glu Cys Ser Ser Pro Ser Pro Val Ile Phe Leu 
305                 310                 315                 320 


Asp Glu Glu Gly Tyr Gln Lys Ser Leu Lys Ala Lys Leu Glu Leu Pro 
                325                 330                 335     


Lys Ile Pro Val Met Lys Asp Asp Ile Glu Asp Ser Asp Ser Glu Val 
            340                 345                 350         


Ser Glu Phe Phe Asp Ser Phe Asp Gln Phe Asp Glu Leu Glu Gln Thr 
        355                 360                 365             


Leu Glu Thr Cys Leu Phe Asn Lys Asp Pro Val Ile Gly Lys Ser Ser 
    370                 375                 380                 


Gln Arg Lys Gly His Lys His Gly Lys Ser Cys Met Asn Pro Gln Lys 
385                 390                 395                 400 


Phe Lys Phe Asp Arg Pro Ala Leu Pro Ala Asn Val Arg Lys Pro Thr 
                405                 410                 415     


Pro Arg Lys Pro Glu Ser Pro Tyr Gly Asn Leu Cys Asp Ala Pro Asp 
            420                 425                 430         


Ser Pro Arg Pro Val Lys Ala Ser Arg Glu Asp Ser Gly Leu Phe Ser 
        435                 440                 445             


Pro Ile Arg Ser Ser Ala Phe Ser Pro Leu Gly Gly Cys Thr Pro Ala 
    450                 455                 460                 


Glu Cys Phe Cys Gln Thr Asp Ile Gly Gly Asp Arg Ile His Glu Asn 
465                 470                 475                 480 


His Asp Ser Val Tyr Tyr Thr Tyr Glu Asp Tyr Ala Lys Ser Ile Ser 
                485                 490                 495     


Cys Glu Val Leu Gly Ser Val Leu Arg Thr His His Thr Asn Thr Leu 
            500                 505                 510         


Ser Asn Ile Asn Ser Ile Lys His Gly Glu Asn Lys Thr Val Thr Phe 
        515                 520                 525             


Lys His Gly Asn Leu Asp Gln Lys Asn Lys Ser Lys Asn Lys Ser Leu 
    530                 535                 540                 


Met Ile Lys Asp Ser Ile Gln Lys Phe Ala Ala Asp Leu Val Glu Lys 
545                 550                 555                 560 


Ser Phe Gly Ser Ala Phe Lys Asp Leu Gln Lys Gly Val Ser Ser Cys 
                565                 570                 575     


Thr Asn Ala Leu Tyr His Leu Ala Ile Lys Leu Thr Ser Ser Val Leu 
            580                 585                 590         


Gln Met Ala Phe Asp Glu Leu Arg Arg Gln Arg Ala Phe Ser Leu Lys 
        595                 600                 605             


Glu Arg Ala Ile Ser Gly Leu Ala Asn Phe Leu Val Ser Glu Ala Leu 
    610                 615                 620                 


Ser Asn Ala Leu Lys Asp Leu Gln Tyr Val Lys Lys Gln Ile Phe Thr 
625                 630                 635                 640 


Asn Thr Val Ala Arg Phe Ala Ala Asp Leu Ala Glu Glu Leu Val Phe 
                645                 650                 655     


Glu Gly Ile Met Glu Val Cys Gln Phe Ser Tyr Pro Gln Thr Pro Ala 
            660                 665                 670         


Ser Pro Gln Cys Gly Ser Phe Asp Phe Glu Asp Lys Val Val Lys Leu 
        675                 680                 685             


Tyr Ala Lys Asp Leu Ser Glu Ser Val Ile Gln Glu Ala Phe Ile Glu 
    690                 695                 700                 


Leu Ser Gln Val Asp Val Thr Phe Thr Thr Lys Ala Ala Val Ser Val 
705                 710                 715                 720 


Ser Thr Asp Asn Ile Lys Tyr Val Ser Ala Glu Ser Val Val Pro Ser 
                725                 730                 735     


Thr Gln Ala Val Thr Phe Ser Pro Ser Phe His Asn Gln Ala Ile Met 
            740                 745                 750         


Val Thr Lys Pro Val Gln Glu Tyr Lys Lys Glu Tyr Thr Val Gln Gln 
        755                 760                 765             


Ala Leu Phe Cys Thr Ser Gly Ile Val Thr Ser Ile Pro Val Pro Leu 
    770                 775                 780                 


Ala Gly Ser Ala Leu Leu Pro Tyr His Ile Ser Ser Thr Ala Cys Gln 
785                 790                 795                 800 


Ala Lys Ala His Leu Ser Ser Asp Asp Ser Asn Ser Asn Gly Asp Ser 
                805                 810                 815     


Ala Gln Val His Ile Ala Thr Lys Asn Arg Glu Glu Lys Ala Ala Cys 
            820                 825                 830         


Leu Arg Asn Ile Cys Leu Pro Ser Glu His Asn Pro Gly Asn Gln Asn 
        835                 840                 845             


Asp Phe Lys Pro Thr Asn Asp Asp Ile Glu Met Gln Ser Ser Ser Lys 
    850                 855                 860                 


Leu Pro Asn Asp Pro Ala Ile Ile Ser Asn Phe Ser Ala Ala Val Val 
865                 870                 875                 880 


His Thr Ile Val Asn Glu Thr Leu Glu Ser Met Thr Ser Leu Glu Val 
                885                 890                 895     


Thr Lys Met Val Asp Glu Arg Thr Asp Tyr Leu Thr Lys Ser Leu Lys 
            900                 905                 910         


Glu Lys Thr Pro Pro Phe Ser His Cys Asp Gln Ala Val Leu Gln Cys 
        915                 920                 925             


Ser Glu Ala Ser Ser Asn Lys Asp Met Phe Ala Asp Arg Leu Ser Lys 
    930                 935                 940                 


Ser Ile Ile Lys His Ser Ile Asp Lys Ser Lys Ser Val Ile Pro Asn 
945                 950                 955                 960 


Ile Asp Lys Asn Ala Val Tyr Lys Glu Ser Leu Pro Val Ser Gly Glu 
                965                 970                 975     


Glu Ser Gln Leu Thr Pro Glu Lys Ser Pro Lys Phe Pro Asp Ser Gln 
            980                 985                 990         


Asn Gln Leu Thr His Cys Ser Leu  Ser Ala Ala Lys Asp  Cys Val Pro 
        995                 1000                 1005             


Glu Cys  Lys Val Ser Met Val  His Gly Ser Ser Leu  Glu Thr Leu 
    1010                 1015                 1020             


Pro Ser  Cys Pro Ala Val Thr  Gly Gln Lys Ser Asp  Leu Lys Glu 
    1025                 1030                 1035             


Ser Ala  Lys Asp Gln Pro Leu  Lys Lys His Asn Leu  Asn Ser Thr 
    1040                 1045                 1050             


Ser Leu  Glu Ala Leu Ser Phe  Gly Gln Glu Asn Pro  Phe Pro His 
    1055                 1060                 1065             


Ser His  Thr Phe Ser Ser Thr  Ala Leu Thr Cys Val  Asp Gly Leu 
    1070                 1075                 1080             


His Val  Glu Asp Lys Gln Lys  Val Arg Asp Arg Asn  Val Ile Pro 
    1085                 1090                 1095             


Asp Thr  Pro Pro Ser Thr Pro  Leu Val Pro Ser Arg  Ala Ser Ser 
    1100                 1105                 1110             


Glu Trp  Asp Ile Lys Lys Leu  Thr Lys Lys Leu Lys  Gly Glu Leu 
    1115                 1120                 1125             


Ala Lys  Glu Phe Ala Pro Ala  Thr Pro Pro Ser Thr  Pro His Asn 
    1130                 1135                 1140             


Ser Ser  Val Gly Ser Leu Ser  Glu Asn Glu Gln Asn  Thr Ile Glu 
    1145                 1150                 1155             


Lys Glu  Glu Phe Met Leu Lys  Leu Met Arg Ser Leu  Ser Glu Glu 
    1160                 1165                 1170             


Val Glu  Ser Ser Glu Ser Gly  Glu Leu Pro Glu Val  Asp Val Lys 
    1175                 1180                 1185             


Ser Glu  His Ser Gly Lys Lys  Val Gln Phe Ala Glu  Ala Leu Ala 
    1190                 1195                 1200             


Thr His  Ile Leu Ser Leu Ala  Thr Glu Met Ala Ala  Ser His Leu 
    1205                 1210                 1215             


Asp Asn  Lys Ile Ile Gln Glu  Pro Lys Val Lys Asn  Pro Cys Leu 
    1220                 1225                 1230             


Asn Val  Gln Ser Gln Arg Ser  Val Ser Pro Thr Phe  Leu Asn Pro 
    1235                 1240                 1245             


Ser Asp  Glu Asn Leu Lys Thr  Leu Cys Asn Phe Ala  Gly Asp Leu 
    1250                 1255                 1260             


Ala Ala  Glu Val Ile Thr Glu  Ala Glu Lys Ile Ala  Lys Val Arg 
    1265                 1270                 1275             


Asn Cys  Met Leu Phe Lys Gln  Lys Lys Asn Ser Cys  Tyr Ala Asp 
    1280                 1285                 1290             


Gly Asp  Glu Asp Tyr Lys Val  Glu Glu Lys Leu Asp  Ile Glu Ala 
    1295                 1300                 1305             


Val Val  His Pro Arg Glu Val  Asp Pro Phe Ile Leu  Ser Leu Pro 
    1310                 1315                 1320             


Pro Ser  Ser Cys Met Ser Gly  Leu Met Tyr Lys Tyr  Pro Ser Cys 
    1325                 1330                 1335             


Glu Ser  Val Thr Asp Glu Tyr  Ala Gly His Leu Ile  Gln Ile Leu 
    1340                 1345                 1350             


Lys Gln  Glu Gly Gly Asn Ser  Glu Leu Ile Met Asp  Gln Tyr Ala 
    1355                 1360                 1365             


Asn Arg  Leu Ala Tyr Arg Ser  Val Lys Ser Gly Leu  Gln Glu Ala 
    1370                 1375                 1380             


Ala Lys  Thr Thr Lys Val Gln  Cys Asn Ser Arg Met  Phe Pro Val 
    1385                 1390                 1395             


Pro Ser  Ser Gln Val Lys Thr  Asn Lys Glu Leu Leu  Met Phe Ser 
    1400                 1405                 1410             


Asn Lys  Glu His His Gln Glu  Ala Asp Lys Lys Arg  Gln Ser Lys 
    1415                 1420                 1425             


Arg Asn  Glu Gly Tyr Phe Cys  Lys Asn Gln Thr Cys  Glu Arg Thr 
    1430                 1435                 1440             


Leu Asp  Pro Tyr Arg Asn Glu  Val Ser Gln Leu Tyr  Ser Phe Ser 
    1445                 1450                 1455             


Thr Ser  Leu Val His Ser Ile  Thr Lys Asp Ala Lys  Glu Glu Leu 
    1460                 1465                 1470             


Thr Ala  Ser Leu Val Gly Leu  Pro Lys Ser Leu Thr  Asp Ser Cys 
    1475                 1480                 1485             


Leu Phe  Glu Lys Ser Gly Tyr  Glu Glu Asp Asn Glu  Cys His Val 
    1490                 1495                 1500             


Thr Pro  Glu Leu Pro Lys Ser  Leu Gln Pro Ser Ser  Gln Asn His 
    1505                 1510                 1515             


Arg Phe  Tyr His Ser Thr Gly  Ser Leu Asn Gly Tyr  Gly Cys Gly 
    1520                 1525                 1530             


Asp Asn  Val Val Gln Ala Val  Glu Gln Tyr Ala Lys  Lys Val Val 
    1535                 1540                 1545             


Asp Asp  Thr Leu Glu Leu Thr  Leu Gly Ser Thr Val  Phe Arg Val 
    1550                 1555                 1560             


Ser Glu  Thr Thr Lys Ser Ala  Asp Arg Val Thr Tyr  Ala Glu Lys 
    1565                 1570                 1575             


Leu Ser  Pro Leu Thr Gly Gln  Ala Cys Arg Tyr Cys  Asp Leu Lys 
    1580                 1585                 1590             


Glu Leu  His Asn Cys Thr Gly  Asn Ser Ser Gln His  Phe Phe Arg 
    1595                 1600                 1605             


Gln Gly  Ser Leu Ala Ser Ser  Lys Pro Ala Ser Asn  Pro Lys Phe 
    1610                 1615                 1620             


Ser Ser  Arg Tyr Gln Lys Ser  Arg Ile Phe His Leu  Ser Val Pro 
    1625                 1630                 1635             


Gln Ile  His Val Asn Leu Asp  Lys Lys Ala Val Leu  Ala Glu Lys 
    1640                 1645                 1650             


Ile Val  Ala Glu Ala Ile Glu  Lys Ala Glu Arg Glu  Leu Ser Ser 
    1655                 1660                 1665             


Thr Ser  Leu Ala Ala Asp Ser  Gly Ile Gly Gln Glu  Gly Ala Ser 
    1670                 1675                 1680             


Phe Ala  Glu Ser Leu Ala Thr  Glu Thr Met Thr Ala  Ala Val Thr 
    1685                 1690                 1695             


Asn Val  Gly His Ala Val Ser  Ser Ser Lys Glu Ile  Glu Asp Phe 
    1700                 1705                 1710             


Gln Ser  Thr Glu Ser Val Ser  Ser Gln Gln Met Asn  Leu Ser Ile 
    1715                 1720                 1725             


Gly Asp  Asp Ser Thr Gly Ser  Trp Ser Asn Leu Ser  Phe Glu Asp 
    1730                 1735                 1740             


Glu His  Gln Asp Glu Ser Ser  Ser Phe His His Leu  Ser Glu Ser 
    1745                 1750                 1755             


Asn Gly  Asn Ser Ser Ser Trp  Ser Ser Leu Gly Leu  Glu Gly Asp 
    1760                 1765                 1770             


Leu Tyr  Glu Asp Asn Leu Ser  Phe Pro Thr Ser Asp  Ser Asp Gly 
    1775                 1780                 1785             


Pro Asp  Asp Lys Asp Glu Glu  His Glu Asp Glu Val  Glu Gly Leu 
    1790                 1795                 1800             


Gly Gln  Asp Gly Lys Thr Leu  Leu Ile Thr Asn Ile  Asp Met Glu 
    1805                 1810                 1815             


Pro Cys  Thr Val Asp Pro Gln  Leu Arg Ile Ile Leu  Gln Trp Leu 
    1820                 1825                 1830             


Ile Ala  Ser Glu Ala Glu Val  Ala Glu Leu Tyr Phe  His Asp Ser 
    1835                 1840                 1845             


Ala Asn  Lys Glu Phe Met Leu  Leu Ser Lys Gln Leu  Gln Glu Lys 
    1850                 1855                 1860             


Gly Trp  Lys Val Gly Asp Leu  Leu Gln Ala Val Leu  Gln Tyr Tyr 
    1865                 1870                 1875             


Glu Val  Met Glu Lys Ala Ser  Ser Glu Glu Arg Cys  Lys Ser Leu 
    1880                 1885                 1890             


Phe Asp  Trp Leu Leu Glu Asn  Ala 
    1895                 1900     

<210>  2999
<211>  3695
<212>  DNA
<213>  Homo sapiens

<400>  2999
aacttccctg atctgtgcgg gggcagtcca gcagctaggc agctgagcag agcgcatctg     60

cctggggcca gtgaggagaa tgcatctaga cagagctttt cgtgctgctg agatctgtta    120

cctaaagcaa taaaaaatgg ccagaggatc agtgtccgat gaggaaatga tggagctcag    180

agaagctttt gccaaagttg atactgatgg caatggatac atcagcttca atgagttgaa    240

tgacttgttc aaggctgctt gcttgccttt gcctgggtat agagtacgag aaattacaga    300

aaacctgatg gctacaggtg atctggacca agatggaagg atcagctttg atgagtttat    360

caagattttc catggcctaa aaagcacaga tgttgccaag acctttagaa aagcaatcaa    420

taagaaggaa gggatttgtg caatcggtgg tacttcagag cagtctagcg ttggcaccca    480

acactcctat tcagaggaag aaaagtatgc ctttgtcaac tggataaaca aagccctgga    540

aaatgatcct gattgtcggc atgtcatccc aatgaaccca aacacgaatg atctctttaa    600

tgctgttgga gatggcattg tcctttgtaa aatgatcaac ctgtcagtgc cagacacaat    660

tgatgaaaga acaatcaaca aaaagaagct aacccctttc accattcagg aaaatctgaa    720

cttggctctg aactctgcct cagccatcgg gtgccatgtg gtcaacatag gggctgagga    780

cctgaaggag gggaagcctt atctggtcct gggacttctg tggcaagtca tcaagattgg    840

gttgtttgct gacattgaac tcagcagaaa tgaagctctg attgctcttt tgagagaagg    900

tgagagcctg gaggatttga tgaaactctc ccctgaagag ctcttgctga ggtgggctaa    960

ttaccacctg gaaaatgcag gctgcaacaa aattggcaac ttcagtactg acatcaagga   1020

ctcaaaagct tattaccacc tgcttgagca ggtggctcca aaaggagatg aagaaggtgt   1080

tcctgctgtt gttattgaca tgtcaggact gcgggagaag gatgacatcc agagggcaga   1140

atgcatgctg cagcaggcgg agaggctggg ctgccggcag tttgtcacag ccacagatgt   1200

tgtccgaggg aaccccaagt tgaacttggc ttttattgcc aacctcttta acagataccc   1260

tgccctgcac aaaccagaga accaggacat tgactggggg gctcttgaag gtgagacgag   1320

agaagagcgg acatttagga actggatgaa ctccctgggt gttaaccctc gagtcaatca   1380

tttgtacagt gacttatcag atgccctggt catcttccag ctctatgaaa agatcaaagt   1440

tcctgttgac tggaacagag taaacaaacc gccatacccc aaactgggag gcaatatgaa   1500

gaagcttgag aattgtaact acgcggtaga attggggaag aatcaagcga agttctccct   1560

ggttggcatc ggtggacaag atctcaatga aggaaaccgc actctcacac tggccttgat   1620

ttggcagcta atgagaaggt atacactgaa tatcctcgaa gaaattggtg gtggccagaa   1680

ggtcaatgat gacattattg tcaactgggt gaatgaaaca ttgagggaag caaagaaaag   1740

ttcatccatc tctagtttca aggacccgaa gattagtaca agtctgcctg ttctggacct   1800

catcgatgcc atccaaccag gttccattaa ctatgacctt ctgaagacag aaaatctgaa   1860

tgatgatgag aaactcaaca atgcaaaata tgccatctct atggcccgaa aaattggagc   1920

aagagtgtat gccctgccag aagacctggt tgaagtgaac cccaaaatgg tcatgaccgt   1980

gtttgcctgc ctcatgggga aaggaatgaa gagggtgtga ggcccaatgg ggctgggtgg   2040

gaggcggtgc actcactcct gactgcccgg cacagatgct ccagggatga ttcaagccat   2100

tccaaagttc aacttggtga cactctataa gattccaaaa agcacatatt agtgcagcca   2160

agtagcctct cctgtattta acaaaaagtg cttcattctt tgcaggaggc ccaacctcct   2220

atatataggt ttctattctt gatttatttg cttcttcgaa aatctagagg aaaagaaaga   2280

agttattttc caggtaccct tctcgctttt gccattagcc aaggatagaa gctgcagtgg   2340

tattaatttt gatataatct ttcaaaccag cttcatgtgg cttccctttt ctttgttcaa   2400

gatgagggcc aggaggggaa acatcacacc tgccctaaac cctgttcctg gaggtcagca   2460

tttgatctgt tgcaagcccc tctttctgtc ccctcttcct accctgcctc ccttgacttt   2520

gctcctcaca cttttggaac catgccttcc gggggggccc atctcttctg gccgtccttg   2580

tctctgggcc acttggagtg tgtgataaat cagtcaagct gttgaagtct caggagtctc   2640

tggtagcctg cagaagtaag cctcatcatc agagcctttc ctcaaaactg gagtcccaaa   2700

tgtcatcagg ttttgttttt tttcagccac taagaacccc tctgctttta actctagaat   2760

ttgggcttgg accagatcta acatcttgaa tactctgccc tctagagcct tcagccttaa   2820

tggaaggttg gatccaagga gggtgtaatg gagcatcaag ccactcggcg gcagcatgga   2880

gctataacta agcatccttt agggttctgc ctctccaggc atttagccct cacattagat   2940

ctagttactg tggtatggct aatacctgtc aacatttgga ggcaatccta ccttgctttt   3000

gcttctagag cttagcatat ctgattgttg tcaggccata ttatcaatgt ttactttttt   3060

ggtactataa aagctttctg ccacccctaa actccagggg ggacaatatg tgccaatcaa   3120

tagcacccct actcacatac acacacacct agccagctgt caagggcaga atgaatctat   3180

gctggataag aaatggtgga actgcgttat gaagagctaa tttactggac aaagaattcc   3240

aaagcaaaac cagaacagta tgaatttgag caggtctcat aggttgagca atttccccct   3300

aaaccaactg aaggctaaaa agcaacaggc cattgtgaac caatgcaaga cgccctctat   3360

catggtgaaa agctccatca atgaggtatc ttctttagtg gtggtatgta atggaactta   3420

gccatttttc aaagcaattg aaatgcattg ctctggatct gttccttggc agtggactca   3480

gaaagccaac atgtggctcc tcccagccca taaccagtat ttttgctgct tctgaataca   3540

aattggttgg ttttgacttc agattgaact tactgtagcc tcagatgatt tcccccctcc   3600

gcctccagga agaaagaatg ttactgcctt aataaaaaat gaaaagagaa tgatgctcaa   3660

aatctttcca aataaaatgt tccctatatt aggtg                              3695


<210>  3000
<211>  627
<212>  PRT
<213>  Homo sapiens

<400>  3000


Met Ala Arg Gly Ser Val Ser Asp Glu Glu Met Met Glu Leu Arg Glu 
1               5                   10                  15      


Ala Phe Ala Lys Val Asp Thr Asp Gly Asn Gly Tyr Ile Ser Phe Asn 
            20                  25                  30          


Glu Leu Asn Asp Leu Phe Lys Ala Ala Cys Leu Pro Leu Pro Gly Tyr 
        35                  40                  45              


Arg Val Arg Glu Ile Thr Glu Asn Leu Met Ala Thr Gly Asp Leu Asp 
    50                  55                  60                  


Gln Asp Gly Arg Ile Ser Phe Asp Glu Phe Ile Lys Ile Phe His Gly 
65                  70                  75                  80  


Leu Lys Ser Thr Asp Val Ala Lys Thr Phe Arg Lys Ala Ile Asn Lys 
                85                  90                  95      


Lys Glu Gly Ile Cys Ala Ile Gly Gly Thr Ser Glu Gln Ser Ser Val 
            100                 105                 110         


Gly Thr Gln His Ser Tyr Ser Glu Glu Glu Lys Tyr Ala Phe Val Asn 
        115                 120                 125             


Trp Ile Asn Lys Ala Leu Glu Asn Asp Pro Asp Cys Arg His Val Ile 
    130                 135                 140                 


Pro Met Asn Pro Asn Thr Asn Asp Leu Phe Asn Ala Val Gly Asp Gly 
145                 150                 155                 160 


Ile Val Leu Cys Lys Met Ile Asn Leu Ser Val Pro Asp Thr Ile Asp 
                165                 170                 175     


Glu Arg Thr Ile Asn Lys Lys Lys Leu Thr Pro Phe Thr Ile Gln Glu 
            180                 185                 190         


Asn Leu Asn Leu Ala Leu Asn Ser Ala Ser Ala Ile Gly Cys His Val 
        195                 200                 205             


Val Asn Ile Gly Ala Glu Asp Leu Lys Glu Gly Lys Pro Tyr Leu Val 
    210                 215                 220                 


Leu Gly Leu Leu Trp Gln Val Ile Lys Ile Gly Leu Phe Ala Asp Ile 
225                 230                 235                 240 


Glu Leu Ser Arg Asn Glu Ala Leu Ile Ala Leu Leu Arg Glu Gly Glu 
                245                 250                 255     


Ser Leu Glu Asp Leu Met Lys Leu Ser Pro Glu Glu Leu Leu Leu Arg 
            260                 265                 270         


Trp Ala Asn Tyr His Leu Glu Asn Ala Gly Cys Asn Lys Ile Gly Asn 
        275                 280                 285             


Phe Ser Thr Asp Ile Lys Asp Ser Lys Ala Tyr Tyr His Leu Leu Glu 
    290                 295                 300                 


Gln Val Ala Pro Lys Gly Asp Glu Glu Gly Val Pro Ala Val Val Ile 
305                 310                 315                 320 


Asp Met Ser Gly Leu Arg Glu Lys Asp Asp Ile Gln Arg Ala Glu Cys 
                325                 330                 335     


Met Leu Gln Gln Ala Glu Arg Leu Gly Cys Arg Gln Phe Val Thr Ala 
            340                 345                 350         


Thr Asp Val Val Arg Gly Asn Pro Lys Leu Asn Leu Ala Phe Ile Ala 
        355                 360                 365             


Asn Leu Phe Asn Arg Tyr Pro Ala Leu His Lys Pro Glu Asn Gln Asp 
    370                 375                 380                 


Ile Asp Trp Gly Ala Leu Glu Gly Glu Thr Arg Glu Glu Arg Thr Phe 
385                 390                 395                 400 


Arg Asn Trp Met Asn Ser Leu Gly Val Asn Pro Arg Val Asn His Leu 
                405                 410                 415     


Tyr Ser Asp Leu Ser Asp Ala Leu Val Ile Phe Gln Leu Tyr Glu Lys 
            420                 425                 430         


Ile Lys Val Pro Val Asp Trp Asn Arg Val Asn Lys Pro Pro Tyr Pro 
        435                 440                 445             


Lys Leu Gly Gly Asn Met Lys Lys Leu Glu Asn Cys Asn Tyr Ala Val 
    450                 455                 460                 


Glu Leu Gly Lys Asn Gln Ala Lys Phe Ser Leu Val Gly Ile Gly Gly 
465                 470                 475                 480 


Gln Asp Leu Asn Glu Gly Asn Arg Thr Leu Thr Leu Ala Leu Ile Trp 
                485                 490                 495     


Gln Leu Met Arg Arg Tyr Thr Leu Asn Ile Leu Glu Glu Ile Gly Gly 
            500                 505                 510         


Gly Gln Lys Val Asn Asp Asp Ile Ile Val Asn Trp Val Asn Glu Thr 
        515                 520                 525             


Leu Arg Glu Ala Lys Lys Ser Ser Ser Ile Ser Ser Phe Lys Asp Pro 
    530                 535                 540                 


Lys Ile Ser Thr Ser Leu Pro Val Leu Asp Leu Ile Asp Ala Ile Gln 
545                 550                 555                 560 


Pro Gly Ser Ile Asn Tyr Asp Leu Leu Lys Thr Glu Asn Leu Asn Asp 
                565                 570                 575     


Asp Glu Lys Leu Asn Asn Ala Lys Tyr Ala Ile Ser Met Ala Arg Lys 
            580                 585                 590         


Ile Gly Ala Arg Val Tyr Ala Leu Pro Glu Asp Leu Val Glu Val Asn 
        595                 600                 605             


Pro Lys Met Val Met Thr Val Phe Ala Cys Leu Met Gly Lys Gly Met 
    610                 615                 620                 


Lys Arg Val 
625         

<210>  3001
<211>  3739
<212>  DNA
<213>  Homo sapiens

<400>  3001
agctggagga gaaagggaga gagaaaaatg cttataaaga gtcacttcct gccttgtgac     60

cacacaccca ggcttgacaa agctgttctg cagatcagaa agaaggggtt cctggtcata    120

caccagtact accaaggaca gcttttttcc tgcaagatct gttacctaaa gcaataaaaa    180

atggccagag gatcagtgtc cgatgaggaa atgatggagc tcagagaagc ttttgccaaa    240

gttgatactg atggcaatgg atacatcagc ttcaatgagt tgaatgactt gttcaaggct    300

gcttgcttgc ctttgcctgg gtatagagta cgagaaatta cagaaaacct gatggctaca    360

ggtgatctgg accaagatgg aaggatcagc tttgatgagt ttatcaagat tttccatggc    420

ctaaaaagca cagatgttgc caagaccttt agaaaagcaa tcaataagaa ggaagggatt    480

tgtgcaatcg gtggtacttc agagcagtct agcgttggca cccaacactc ctattcagag    540

gaagaaaagt atgcctttgt caactggata aacaaagccc tggaaaatga tcctgattgt    600

cggcatgtca tcccaatgaa cccaaacacg aatgatctct ttaatgctgt tggagatggc    660

attgtccttt gtaaaatgat caacctgtca gtgccagaca caattgatga aagaacaatc    720

aacaaaaaga agctaacccc tttcaccatt caggaaaatc tgaacttggc tctgaactct    780

gcctcagcca tcgggtgcca tgtggtcaac ataggggctg aggacctgaa ggaggggaag    840

ccttatctgg tcctgggact tctgtggcaa gtcatcaaga ttgggttgtt tgctgacatt    900

gaactcagca gaaatgaagc tctgattgct cttttgagag aaggtgagag cctggaggat    960

ttgatgaaac tctcccctga agagctcttg ctgaggtggg ctaattacca cctggaaaat   1020

gcaggctgca acaaaattgg caacttcagt actgacatca aggactcaaa agcttattac   1080

cacctgcttg agcaggtggc tccaaaagga gatgaagaag gtgttcctgc tgttgttatt   1140

gacatgtcag gactgcggga gaaggatgac atccagaggg cagaatgcat gctgcagcag   1200

gcggagaggc tgggctgccg gcagtttgtc acagccacag atgttgtccg agggaacccc   1260

aagttgaact tggcttttat tgccaacctc tttaacagat accctgccct gcacaaacca   1320

gagaaccagg acattgactg gggggctctt gaaggtgaga cgagagaaga gcggacattt   1380

aggaactgga tgaactccct gggtgttaac cctcgagtca atcatttgta cagtgactta   1440

tcagatgccc tggtcatctt ccagctctat gaaaagatca aagttcctgt tgactggaac   1500

agagtaaaca aaccgccata ccccaaactg ggaggcaata tgaagaagct tgagaattgt   1560

aactacgcgg tagaattggg gaagaatcaa gcgaagttct ccctggttgg catcggtgga   1620

caagatctca atgaaggaaa ccgcactctc acactggcct tgatttggca gctaatgaga   1680

aggtatacac tgaatatcct cgaagaaatt ggtggtggcc agaaggtcaa tgatgacatt   1740

attgtcaact gggtgaatga aacattgagg gaagcaaaga aaagttcatc catctctagt   1800

ttcaaggacc cgaagattag tacaagtctg cctgttctgg acctcatcga tgccatccaa   1860

ccaggttcca ttaactatga ccttctgaag acagaaaatc tgaatgatga tgagaaactc   1920

aacaatgcaa aatatgccat ctctatggcc cgaaaaattg gagcaagagt gtatgccctg   1980

ccagaagacc tggttgaagt gaaccccaaa atggtcatga ccgtgtttgc ctgcctcatg   2040

gggaaaggaa tgaagagggt gtgaggccca atggggctgg gtgggaggcg gtgcactcac   2100

tcctgactgc ccggcacaga tgctccaggg atgattcaag ccattccaaa gttcaacttg   2160

gtgacactct ataagattcc aaaaagcaca tattagtgca gccaagtagc ctctcctgta   2220

tttaacaaaa agtgcttcat tctttgcagg aggcccaacc tcctatatat aggtttctat   2280

tcttgattta tttgcttctt cgaaaatcta gaggaaaaga aagaagttat tttccaggta   2340

cccttctcgc ttttgccatt agccaaggat agaagctgca gtggtattaa ttttgatata   2400

atctttcaaa ccagcttcat gtggcttccc ttttctttgt tcaagatgag ggccaggagg   2460

ggaaacatca cacctgccct aaaccctgtt cctggaggtc agcatttgat ctgttgcaag   2520

cccctctttc tgtcccctct tcctaccctg cctcccttga ctttgctcct cacacttttg   2580

gaaccatgcc ttccgggggg gcccatctct tctggccgtc cttgtctctg ggccacttgg   2640

agtgtgtgat aaatcagtca agctgttgaa gtctcaggag tctctggtag cctgcagaag   2700

taagcctcat catcagagcc tttcctcaaa actggagtcc caaatgtcat caggttttgt   2760

tttttttcag ccactaagaa cccctctgct tttaactcta gaatttgggc ttggaccaga   2820

tctaacatct tgaatactct gccctctaga gccttcagcc ttaatggaag gttggatcca   2880

aggagggtgt aatggagcat caagccactc ggcggcagca tggagctata actaagcatc   2940

ctttagggtt ctgcctctcc aggcatttag ccctcacatt agatctagtt actgtggtat   3000

ggctaatacc tgtcaacatt tggaggcaat cctaccttgc ttttgcttct agagcttagc   3060

atatctgatt gttgtcaggc catattatca atgtttactt ttttggtact ataaaagctt   3120

tctgccaccc ctaaactcca ggggggacaa tatgtgccaa tcaatagcac ccctactcac   3180

atacacacac acctagccag ctgtcaaggg cagaatgaat ctatgctgga taagaaatgg   3240

tggaactgcg ttatgaagag ctaatttact ggacaaagaa ttccaaagca aaaccagaac   3300

agtatgaatt tgagcaggtc tcataggttg agcaatttcc ccctaaacca actgaaggct   3360

aaaaagcaac aggccattgt gaaccaatgc aagacgccct ctatcatggt gaaaagctcc   3420

atcaatgagg tatcttcttt agtggtggta tgtaatggaa cttagccatt tttcaaagca   3480

attgaaatgc attgctctgg atctgttcct tggcagtgga ctcagaaagc caacatgtgg   3540

ctcctcccag cccataacca gtatttttgc tgcttctgaa tacaaattgg ttggttttga   3600

cttcagattg aacttactgt agcctcagat gatttccccc ctccgcctcc aggaagaaag   3660

aatgttactg ccttaataaa aaatgaaaag agaatgatgc tcaaaatctt tccaaataaa   3720

atgttcccta tattaggtg                                                3739


<210>  3002
<211>  627
<212>  PRT
<213>  Homo sapiens

<400>  3002


Met Ala Arg Gly Ser Val Ser Asp Glu Glu Met Met Glu Leu Arg Glu 
1               5                   10                  15      


Ala Phe Ala Lys Val Asp Thr Asp Gly Asn Gly Tyr Ile Ser Phe Asn 
            20                  25                  30          


Glu Leu Asn Asp Leu Phe Lys Ala Ala Cys Leu Pro Leu Pro Gly Tyr 
        35                  40                  45              


Arg Val Arg Glu Ile Thr Glu Asn Leu Met Ala Thr Gly Asp Leu Asp 
    50                  55                  60                  


Gln Asp Gly Arg Ile Ser Phe Asp Glu Phe Ile Lys Ile Phe His Gly 
65                  70                  75                  80  


Leu Lys Ser Thr Asp Val Ala Lys Thr Phe Arg Lys Ala Ile Asn Lys 
                85                  90                  95      


Lys Glu Gly Ile Cys Ala Ile Gly Gly Thr Ser Glu Gln Ser Ser Val 
            100                 105                 110         


Gly Thr Gln His Ser Tyr Ser Glu Glu Glu Lys Tyr Ala Phe Val Asn 
        115                 120                 125             


Trp Ile Asn Lys Ala Leu Glu Asn Asp Pro Asp Cys Arg His Val Ile 
    130                 135                 140                 


Pro Met Asn Pro Asn Thr Asn Asp Leu Phe Asn Ala Val Gly Asp Gly 
145                 150                 155                 160 


Ile Val Leu Cys Lys Met Ile Asn Leu Ser Val Pro Asp Thr Ile Asp 
                165                 170                 175     


Glu Arg Thr Ile Asn Lys Lys Lys Leu Thr Pro Phe Thr Ile Gln Glu 
            180                 185                 190         


Asn Leu Asn Leu Ala Leu Asn Ser Ala Ser Ala Ile Gly Cys His Val 
        195                 200                 205             


Val Asn Ile Gly Ala Glu Asp Leu Lys Glu Gly Lys Pro Tyr Leu Val 
    210                 215                 220                 


Leu Gly Leu Leu Trp Gln Val Ile Lys Ile Gly Leu Phe Ala Asp Ile 
225                 230                 235                 240 


Glu Leu Ser Arg Asn Glu Ala Leu Ile Ala Leu Leu Arg Glu Gly Glu 
                245                 250                 255     


Ser Leu Glu Asp Leu Met Lys Leu Ser Pro Glu Glu Leu Leu Leu Arg 
            260                 265                 270         


Trp Ala Asn Tyr His Leu Glu Asn Ala Gly Cys Asn Lys Ile Gly Asn 
        275                 280                 285             


Phe Ser Thr Asp Ile Lys Asp Ser Lys Ala Tyr Tyr His Leu Leu Glu 
    290                 295                 300                 


Gln Val Ala Pro Lys Gly Asp Glu Glu Gly Val Pro Ala Val Val Ile 
305                 310                 315                 320 


Asp Met Ser Gly Leu Arg Glu Lys Asp Asp Ile Gln Arg Ala Glu Cys 
                325                 330                 335     


Met Leu Gln Gln Ala Glu Arg Leu Gly Cys Arg Gln Phe Val Thr Ala 
            340                 345                 350         


Thr Asp Val Val Arg Gly Asn Pro Lys Leu Asn Leu Ala Phe Ile Ala 
        355                 360                 365             


Asn Leu Phe Asn Arg Tyr Pro Ala Leu His Lys Pro Glu Asn Gln Asp 
    370                 375                 380                 


Ile Asp Trp Gly Ala Leu Glu Gly Glu Thr Arg Glu Glu Arg Thr Phe 
385                 390                 395                 400 


Arg Asn Trp Met Asn Ser Leu Gly Val Asn Pro Arg Val Asn His Leu 
                405                 410                 415     


Tyr Ser Asp Leu Ser Asp Ala Leu Val Ile Phe Gln Leu Tyr Glu Lys 
            420                 425                 430         


Ile Lys Val Pro Val Asp Trp Asn Arg Val Asn Lys Pro Pro Tyr Pro 
        435                 440                 445             


Lys Leu Gly Gly Asn Met Lys Lys Leu Glu Asn Cys Asn Tyr Ala Val 
    450                 455                 460                 


Glu Leu Gly Lys Asn Gln Ala Lys Phe Ser Leu Val Gly Ile Gly Gly 
465                 470                 475                 480 


Gln Asp Leu Asn Glu Gly Asn Arg Thr Leu Thr Leu Ala Leu Ile Trp 
                485                 490                 495     


Gln Leu Met Arg Arg Tyr Thr Leu Asn Ile Leu Glu Glu Ile Gly Gly 
            500                 505                 510         


Gly Gln Lys Val Asn Asp Asp Ile Ile Val Asn Trp Val Asn Glu Thr 
        515                 520                 525             


Leu Arg Glu Ala Lys Lys Ser Ser Ser Ile Ser Ser Phe Lys Asp Pro 
    530                 535                 540                 


Lys Ile Ser Thr Ser Leu Pro Val Leu Asp Leu Ile Asp Ala Ile Gln 
545                 550                 555                 560 


Pro Gly Ser Ile Asn Tyr Asp Leu Leu Lys Thr Glu Asn Leu Asn Asp 
                565                 570                 575     


Asp Glu Lys Leu Asn Asn Ala Lys Tyr Ala Ile Ser Met Ala Arg Lys 
            580                 585                 590         


Ile Gly Ala Arg Val Tyr Ala Leu Pro Glu Asp Leu Val Glu Val Asn 
        595                 600                 605             


Pro Lys Met Val Met Thr Val Phe Ala Cys Leu Met Gly Lys Gly Met 
    610                 615                 620                 


Lys Arg Val 
625         

<210>  3003
<211>  3795
<212>  DNA
<213>  Homo sapiens

<400>  3003
aaggaagtcc cttttcattt gtttcaggtg tactgccacc tttttccctg gctctttcac     60

taaaaatgaa aaatttgttg atctttgctg taagtagtca cttcctgcct tgtgaccaca    120

cacccaggct tgacaaagct gttctgcaga tcagaaagaa ggggttcctg gtcatacacc    180

agtactacca aggacagctt ttttcctgca agatctgtta cctaaagcaa taaaaaatgg    240

ccagaggatc agtgtccgat gaggaaatga tggagctcag agaagctttt gccaaagttg    300

atactgatgg caatggatac atcagcttca atgagttgaa tgacttgttc aaggctgctt    360

gcttgccttt gcctgggtat agagtacgag aaattacaga aaacctgatg gctacaggtg    420

atctggacca agatggaagg atcagctttg atgagtttat caagattttc catggcctaa    480

aaagcacaga tgttgccaag acctttagaa aagcaatcaa taagaaggaa gggatttgtg    540

caatcggtgg tacttcagag cagtctagcg ttggcaccca acactcctat tcagaggaag    600

aaaagtatgc ctttgtcaac tggataaaca aagccctgga aaatgatcct gattgtcggc    660

atgtcatccc aatgaaccca aacacgaatg atctctttaa tgctgttgga gatggcattg    720

tcctttgtaa aatgatcaac ctgtcagtgc cagacacaat tgatgaaaga acaatcaaca    780

aaaagaagct aacccctttc accattcagg aaaatctgaa cttggctctg aactctgcct    840

cagccatcgg gtgccatgtg gtcaacatag gggctgagga cctgaaggag gggaagcctt    900

atctggtcct gggacttctg tggcaagtca tcaagattgg gttgtttgct gacattgaac    960

tcagcagaaa tgaagctctg attgctcttt tgagagaagg tgagagcctg gaggatttga   1020

tgaaactctc ccctgaagag ctcttgctga ggtgggctaa ttaccacctg gaaaatgcag   1080

gctgcaacaa aattggcaac ttcagtactg acatcaagga ctcaaaagct tattaccacc   1140

tgcttgagca ggtggctcca aaaggagatg aagaaggtgt tcctgctgtt gttattgaca   1200

tgtcaggact gcgggagaag gatgacatcc agagggcaga atgcatgctg cagcaggcgg   1260

agaggctggg ctgccggcag tttgtcacag ccacagatgt tgtccgaggg aaccccaagt   1320

tgaacttggc ttttattgcc aacctcttta acagataccc tgccctgcac aaaccagaga   1380

accaggacat tgactggggg gctcttgaag gtgagacgag agaagagcgg acatttagga   1440

actggatgaa ctccctgggt gttaaccctc gagtcaatca tttgtacagt gacttatcag   1500

atgccctggt catcttccag ctctatgaaa agatcaaagt tcctgttgac tggaacagag   1560

taaacaaacc gccatacccc aaactgggag gcaatatgaa gaagcttgag aattgtaact   1620

acgcggtaga attggggaag aatcaagcga agttctccct ggttggcatc ggtggacaag   1680

atctcaatga aggaaaccgc actctcacac tggccttgat ttggcagcta atgagaaggt   1740

atacactgaa tatcctcgaa gaaattggtg gtggccagaa ggtcaatgat gacattattg   1800

tcaactgggt gaatgaaaca ttgagggaag caaagaaaag ttcatccatc tctagtttca   1860

aggacccgaa gattagtaca agtctgcctg ttctggacct catcgatgcc atccaaccag   1920

gttccattaa ctatgacctt ctgaagacag aaaatctgaa tgatgatgag aaactcaaca   1980

atgcaaaata tgccatctct atggcccgaa aaattggagc aagagtgtat gccctgccag   2040

aagacctggt tgaagtgaac cccaaaatgg tcatgaccgt gtttgcctgc ctcatgggga   2100

aaggaatgaa gagggtgtga ggcccaatgg ggctgggtgg gaggcggtgc actcactcct   2160

gactgcccgg cacagatgct ccagggatga ttcaagccat tccaaagttc aacttggtga   2220

cactctataa gattccaaaa agcacatatt agtgcagcca agtagcctct cctgtattta   2280

acaaaaagtg cttcattctt tgcaggaggc ccaacctcct atatataggt ttctattctt   2340

gatttatttg cttcttcgaa aatctagagg aaaagaaaga agttattttc caggtaccct   2400

tctcgctttt gccattagcc aaggatagaa gctgcagtgg tattaatttt gatataatct   2460

ttcaaaccag cttcatgtgg cttccctttt ctttgttcaa gatgagggcc aggaggggaa   2520

acatcacacc tgccctaaac cctgttcctg gaggtcagca tttgatctgt tgcaagcccc   2580

tctttctgtc ccctcttcct accctgcctc ccttgacttt gctcctcaca cttttggaac   2640

catgccttcc gggggggccc atctcttctg gccgtccttg tctctgggcc acttggagtg   2700

tgtgataaat cagtcaagct gttgaagtct caggagtctc tggtagcctg cagaagtaag   2760

cctcatcatc agagcctttc ctcaaaactg gagtcccaaa tgtcatcagg ttttgttttt   2820

tttcagccac taagaacccc tctgctttta actctagaat ttgggcttgg accagatcta   2880

acatcttgaa tactctgccc tctagagcct tcagccttaa tggaaggttg gatccaagga   2940

gggtgtaatg gagcatcaag ccactcggcg gcagcatgga gctataacta agcatccttt   3000

agggttctgc ctctccaggc atttagccct cacattagat ctagttactg tggtatggct   3060

aatacctgtc aacatttgga ggcaatccta ccttgctttt gcttctagag cttagcatat   3120

ctgattgttg tcaggccata ttatcaatgt ttactttttt ggtactataa aagctttctg   3180

ccacccctaa actccagggg ggacaatatg tgccaatcaa tagcacccct actcacatac   3240

acacacacct agccagctgt caagggcaga atgaatctat gctggataag aaatggtgga   3300

actgcgttat gaagagctaa tttactggac aaagaattcc aaagcaaaac cagaacagta   3360

tgaatttgag caggtctcat aggttgagca atttccccct aaaccaactg aaggctaaaa   3420

agcaacaggc cattgtgaac caatgcaaga cgccctctat catggtgaaa agctccatca   3480

atgaggtatc ttctttagtg gtggtatgta atggaactta gccatttttc aaagcaattg   3540

aaatgcattg ctctggatct gttccttggc agtggactca gaaagccaac atgtggctcc   3600

tcccagccca taaccagtat ttttgctgct tctgaataca aattggttgg ttttgacttc   3660

agattgaact tactgtagcc tcagatgatt tcccccctcc gcctccagga agaaagaatg   3720

ttactgcctt aataaaaaat gaaaagagaa tgatgctcaa aatctttcca aataaaatgt   3780

tccctatatt aggtg                                                    3795


<210>  3004
<211>  627
<212>  PRT
<213>  Homo sapiens

<400>  3004


Met Ala Arg Gly Ser Val Ser Asp Glu Glu Met Met Glu Leu Arg Glu 
1               5                   10                  15      


Ala Phe Ala Lys Val Asp Thr Asp Gly Asn Gly Tyr Ile Ser Phe Asn 
            20                  25                  30          


Glu Leu Asn Asp Leu Phe Lys Ala Ala Cys Leu Pro Leu Pro Gly Tyr 
        35                  40                  45              


Arg Val Arg Glu Ile Thr Glu Asn Leu Met Ala Thr Gly Asp Leu Asp 
    50                  55                  60                  


Gln Asp Gly Arg Ile Ser Phe Asp Glu Phe Ile Lys Ile Phe His Gly 
65                  70                  75                  80  


Leu Lys Ser Thr Asp Val Ala Lys Thr Phe Arg Lys Ala Ile Asn Lys 
                85                  90                  95      


Lys Glu Gly Ile Cys Ala Ile Gly Gly Thr Ser Glu Gln Ser Ser Val 
            100                 105                 110         


Gly Thr Gln His Ser Tyr Ser Glu Glu Glu Lys Tyr Ala Phe Val Asn 
        115                 120                 125             


Trp Ile Asn Lys Ala Leu Glu Asn Asp Pro Asp Cys Arg His Val Ile 
    130                 135                 140                 


Pro Met Asn Pro Asn Thr Asn Asp Leu Phe Asn Ala Val Gly Asp Gly 
145                 150                 155                 160 


Ile Val Leu Cys Lys Met Ile Asn Leu Ser Val Pro Asp Thr Ile Asp 
                165                 170                 175     


Glu Arg Thr Ile Asn Lys Lys Lys Leu Thr Pro Phe Thr Ile Gln Glu 
            180                 185                 190         


Asn Leu Asn Leu Ala Leu Asn Ser Ala Ser Ala Ile Gly Cys His Val 
        195                 200                 205             


Val Asn Ile Gly Ala Glu Asp Leu Lys Glu Gly Lys Pro Tyr Leu Val 
    210                 215                 220                 


Leu Gly Leu Leu Trp Gln Val Ile Lys Ile Gly Leu Phe Ala Asp Ile 
225                 230                 235                 240 


Glu Leu Ser Arg Asn Glu Ala Leu Ile Ala Leu Leu Arg Glu Gly Glu 
                245                 250                 255     


Ser Leu Glu Asp Leu Met Lys Leu Ser Pro Glu Glu Leu Leu Leu Arg 
            260                 265                 270         


Trp Ala Asn Tyr His Leu Glu Asn Ala Gly Cys Asn Lys Ile Gly Asn 
        275                 280                 285             


Phe Ser Thr Asp Ile Lys Asp Ser Lys Ala Tyr Tyr His Leu Leu Glu 
    290                 295                 300                 


Gln Val Ala Pro Lys Gly Asp Glu Glu Gly Val Pro Ala Val Val Ile 
305                 310                 315                 320 


Asp Met Ser Gly Leu Arg Glu Lys Asp Asp Ile Gln Arg Ala Glu Cys 
                325                 330                 335     


Met Leu Gln Gln Ala Glu Arg Leu Gly Cys Arg Gln Phe Val Thr Ala 
            340                 345                 350         


Thr Asp Val Val Arg Gly Asn Pro Lys Leu Asn Leu Ala Phe Ile Ala 
        355                 360                 365             


Asn Leu Phe Asn Arg Tyr Pro Ala Leu His Lys Pro Glu Asn Gln Asp 
    370                 375                 380                 


Ile Asp Trp Gly Ala Leu Glu Gly Glu Thr Arg Glu Glu Arg Thr Phe 
385                 390                 395                 400 


Arg Asn Trp Met Asn Ser Leu Gly Val Asn Pro Arg Val Asn His Leu 
                405                 410                 415     


Tyr Ser Asp Leu Ser Asp Ala Leu Val Ile Phe Gln Leu Tyr Glu Lys 
            420                 425                 430         


Ile Lys Val Pro Val Asp Trp Asn Arg Val Asn Lys Pro Pro Tyr Pro 
        435                 440                 445             


Lys Leu Gly Gly Asn Met Lys Lys Leu Glu Asn Cys Asn Tyr Ala Val 
    450                 455                 460                 


Glu Leu Gly Lys Asn Gln Ala Lys Phe Ser Leu Val Gly Ile Gly Gly 
465                 470                 475                 480 


Gln Asp Leu Asn Glu Gly Asn Arg Thr Leu Thr Leu Ala Leu Ile Trp 
                485                 490                 495     


Gln Leu Met Arg Arg Tyr Thr Leu Asn Ile Leu Glu Glu Ile Gly Gly 
            500                 505                 510         


Gly Gln Lys Val Asn Asp Asp Ile Ile Val Asn Trp Val Asn Glu Thr 
        515                 520                 525             


Leu Arg Glu Ala Lys Lys Ser Ser Ser Ile Ser Ser Phe Lys Asp Pro 
    530                 535                 540                 


Lys Ile Ser Thr Ser Leu Pro Val Leu Asp Leu Ile Asp Ala Ile Gln 
545                 550                 555                 560 


Pro Gly Ser Ile Asn Tyr Asp Leu Leu Lys Thr Glu Asn Leu Asn Asp 
                565                 570                 575     


Asp Glu Lys Leu Asn Asn Ala Lys Tyr Ala Ile Ser Met Ala Arg Lys 
            580                 585                 590         


Ile Gly Ala Arg Val Tyr Ala Leu Pro Glu Asp Leu Val Glu Val Asn 
        595                 600                 605             


Pro Lys Met Val Met Thr Val Phe Ala Cys Leu Met Gly Lys Gly Met 
    610                 615                 620                 


Lys Arg Val 
625         

<210>  3005
<211>  3735
<212>  DNA
<213>  Homo sapiens

<400>  3005
atcactgtta gaggactcca gagaggtttg atttcagtca cttcctgcct tgtgaccaca     60

cacccaggct tgacaaagct gttctgcaga tcagaaagaa ggggttcctg gtcatacacc    120

agtactacca aggacagctt ttttcctgca agatctgtta cctaaagcaa taaaaaatgg    180

ccagaggatc agtgtccgat gaggaaatga tggagctcag agaagctttt gccaaagttg    240

atactgatgg caatggatac atcagcttca atgagttgaa tgacttgttc aaggctgctt    300

gcttgccttt gcctgggtat agagtacgag aaattacaga aaacctgatg gctacaggtg    360

atctggacca agatggaagg atcagctttg atgagtttat caagattttc catggcctaa    420

aaagcacaga tgttgccaag acctttagaa aagcaatcaa taagaaggaa gggatttgtg    480

caatcggtgg tacttcagag cagtctagcg ttggcaccca acactcctat tcagaggaag    540

aaaagtatgc ctttgtcaac tggataaaca aagccctgga aaatgatcct gattgtcggc    600

atgtcatccc aatgaaccca aacacgaatg atctctttaa tgctgttgga gatggcattg    660

tcctttgtaa aatgatcaac ctgtcagtgc cagacacaat tgatgaaaga acaatcaaca    720

aaaagaagct aacccctttc accattcagg aaaatctgaa cttggctctg aactctgcct    780

cagccatcgg gtgccatgtg gtcaacatag gggctgagga cctgaaggag gggaagcctt    840

atctggtcct gggacttctg tggcaagtca tcaagattgg gttgtttgct gacattgaac    900

tcagcagaaa tgaagctctg attgctcttt tgagagaagg tgagagcctg gaggatttga    960

tgaaactctc ccctgaagag ctcttgctga ggtgggctaa ttaccacctg gaaaatgcag   1020

gctgcaacaa aattggcaac ttcagtactg acatcaagga ctcaaaagct tattaccacc   1080

tgcttgagca ggtggctcca aaaggagatg aagaaggtgt tcctgctgtt gttattgaca   1140

tgtcaggact gcgggagaag gatgacatcc agagggcaga atgcatgctg cagcaggcgg   1200

agaggctggg ctgccggcag tttgtcacag ccacagatgt tgtccgaggg aaccccaagt   1260

tgaacttggc ttttattgcc aacctcttta acagataccc tgccctgcac aaaccagaga   1320

accaggacat tgactggggg gctcttgaag gtgagacgag agaagagcgg acatttagga   1380

actggatgaa ctccctgggt gttaaccctc gagtcaatca tttgtacagt gacttatcag   1440

atgccctggt catcttccag ctctatgaaa agatcaaagt tcctgttgac tggaacagag   1500

taaacaaacc gccatacccc aaactgggag gcaatatgaa gaagcttgag aattgtaact   1560

acgcggtaga attggggaag aatcaagcga agttctccct ggttggcatc ggtggacaag   1620

atctcaatga aggaaaccgc actctcacac tggccttgat ttggcagcta atgagaaggt   1680

atacactgaa tatcctcgaa gaaattggtg gtggccagaa ggtcaatgat gacattattg   1740

tcaactgggt gaatgaaaca ttgagggaag caaagaaaag ttcatccatc tctagtttca   1800

aggacccgaa gattagtaca agtctgcctg ttctggacct catcgatgcc atccaaccag   1860

gttccattaa ctatgacctt ctgaagacag aaaatctgaa tgatgatgag aaactcaaca   1920

atgcaaaata tgccatctct atggcccgaa aaattggagc aagagtgtat gccctgccag   1980

aagacctggt tgaagtgaac cccaaaatgg tcatgaccgt gtttgcctgc ctcatgggga   2040

aaggaatgaa gagggtgtga ggcccaatgg ggctgggtgg gaggcggtgc actcactcct   2100

gactgcccgg cacagatgct ccagggatga ttcaagccat tccaaagttc aacttggtga   2160

cactctataa gattccaaaa agcacatatt agtgcagcca agtagcctct cctgtattta   2220

acaaaaagtg cttcattctt tgcaggaggc ccaacctcct atatataggt ttctattctt   2280

gatttatttg cttcttcgaa aatctagagg aaaagaaaga agttattttc caggtaccct   2340

tctcgctttt gccattagcc aaggatagaa gctgcagtgg tattaatttt gatataatct   2400

ttcaaaccag cttcatgtgg cttccctttt ctttgttcaa gatgagggcc aggaggggaa   2460

acatcacacc tgccctaaac cctgttcctg gaggtcagca tttgatctgt tgcaagcccc   2520

tctttctgtc ccctcttcct accctgcctc ccttgacttt gctcctcaca cttttggaac   2580

catgccttcc gggggggccc atctcttctg gccgtccttg tctctgggcc acttggagtg   2640

tgtgataaat cagtcaagct gttgaagtct caggagtctc tggtagcctg cagaagtaag   2700

cctcatcatc agagcctttc ctcaaaactg gagtcccaaa tgtcatcagg ttttgttttt   2760

tttcagccac taagaacccc tctgctttta actctagaat ttgggcttgg accagatcta   2820

acatcttgaa tactctgccc tctagagcct tcagccttaa tggaaggttg gatccaagga   2880

gggtgtaatg gagcatcaag ccactcggcg gcagcatgga gctataacta agcatccttt   2940

agggttctgc ctctccaggc atttagccct cacattagat ctagttactg tggtatggct   3000

aatacctgtc aacatttgga ggcaatccta ccttgctttt gcttctagag cttagcatat   3060

ctgattgttg tcaggccata ttatcaatgt ttactttttt ggtactataa aagctttctg   3120

ccacccctaa actccagggg ggacaatatg tgccaatcaa tagcacccct actcacatac   3180

acacacacct agccagctgt caagggcaga atgaatctat gctggataag aaatggtgga   3240

actgcgttat gaagagctaa tttactggac aaagaattcc aaagcaaaac cagaacagta   3300

tgaatttgag caggtctcat aggttgagca atttccccct aaaccaactg aaggctaaaa   3360

agcaacaggc cattgtgaac caatgcaaga cgccctctat catggtgaaa agctccatca   3420

atgaggtatc ttctttagtg gtggtatgta atggaactta gccatttttc aaagcaattg   3480

aaatgcattg ctctggatct gttccttggc agtggactca gaaagccaac atgtggctcc   3540

tcccagccca taaccagtat ttttgctgct tctgaataca aattggttgg ttttgacttc   3600

agattgaact tactgtagcc tcagatgatt tcccccctcc gcctccagga agaaagaatg   3660

ttactgcctt aataaaaaat gaaaagagaa tgatgctcaa aatctttcca aataaaatgt   3720

tccctatatt aggtg                                                    3735


<210>  3006
<211>  627
<212>  PRT
<213>  Homo sapiens

<400>  3006


Met Ala Arg Gly Ser Val Ser Asp Glu Glu Met Met Glu Leu Arg Glu 
1               5                   10                  15      


Ala Phe Ala Lys Val Asp Thr Asp Gly Asn Gly Tyr Ile Ser Phe Asn 
            20                  25                  30          


Glu Leu Asn Asp Leu Phe Lys Ala Ala Cys Leu Pro Leu Pro Gly Tyr 
        35                  40                  45              


Arg Val Arg Glu Ile Thr Glu Asn Leu Met Ala Thr Gly Asp Leu Asp 
    50                  55                  60                  


Gln Asp Gly Arg Ile Ser Phe Asp Glu Phe Ile Lys Ile Phe His Gly 
65                  70                  75                  80  


Leu Lys Ser Thr Asp Val Ala Lys Thr Phe Arg Lys Ala Ile Asn Lys 
                85                  90                  95      


Lys Glu Gly Ile Cys Ala Ile Gly Gly Thr Ser Glu Gln Ser Ser Val 
            100                 105                 110         


Gly Thr Gln His Ser Tyr Ser Glu Glu Glu Lys Tyr Ala Phe Val Asn 
        115                 120                 125             


Trp Ile Asn Lys Ala Leu Glu Asn Asp Pro Asp Cys Arg His Val Ile 
    130                 135                 140                 


Pro Met Asn Pro Asn Thr Asn Asp Leu Phe Asn Ala Val Gly Asp Gly 
145                 150                 155                 160 


Ile Val Leu Cys Lys Met Ile Asn Leu Ser Val Pro Asp Thr Ile Asp 
                165                 170                 175     


Glu Arg Thr Ile Asn Lys Lys Lys Leu Thr Pro Phe Thr Ile Gln Glu 
            180                 185                 190         


Asn Leu Asn Leu Ala Leu Asn Ser Ala Ser Ala Ile Gly Cys His Val 
        195                 200                 205             


Val Asn Ile Gly Ala Glu Asp Leu Lys Glu Gly Lys Pro Tyr Leu Val 
    210                 215                 220                 


Leu Gly Leu Leu Trp Gln Val Ile Lys Ile Gly Leu Phe Ala Asp Ile 
225                 230                 235                 240 


Glu Leu Ser Arg Asn Glu Ala Leu Ile Ala Leu Leu Arg Glu Gly Glu 
                245                 250                 255     


Ser Leu Glu Asp Leu Met Lys Leu Ser Pro Glu Glu Leu Leu Leu Arg 
            260                 265                 270         


Trp Ala Asn Tyr His Leu Glu Asn Ala Gly Cys Asn Lys Ile Gly Asn 
        275                 280                 285             


Phe Ser Thr Asp Ile Lys Asp Ser Lys Ala Tyr Tyr His Leu Leu Glu 
    290                 295                 300                 


Gln Val Ala Pro Lys Gly Asp Glu Glu Gly Val Pro Ala Val Val Ile 
305                 310                 315                 320 


Asp Met Ser Gly Leu Arg Glu Lys Asp Asp Ile Gln Arg Ala Glu Cys 
                325                 330                 335     


Met Leu Gln Gln Ala Glu Arg Leu Gly Cys Arg Gln Phe Val Thr Ala 
            340                 345                 350         


Thr Asp Val Val Arg Gly Asn Pro Lys Leu Asn Leu Ala Phe Ile Ala 
        355                 360                 365             


Asn Leu Phe Asn Arg Tyr Pro Ala Leu His Lys Pro Glu Asn Gln Asp 
    370                 375                 380                 


Ile Asp Trp Gly Ala Leu Glu Gly Glu Thr Arg Glu Glu Arg Thr Phe 
385                 390                 395                 400 


Arg Asn Trp Met Asn Ser Leu Gly Val Asn Pro Arg Val Asn His Leu 
                405                 410                 415     


Tyr Ser Asp Leu Ser Asp Ala Leu Val Ile Phe Gln Leu Tyr Glu Lys 
            420                 425                 430         


Ile Lys Val Pro Val Asp Trp Asn Arg Val Asn Lys Pro Pro Tyr Pro 
        435                 440                 445             


Lys Leu Gly Gly Asn Met Lys Lys Leu Glu Asn Cys Asn Tyr Ala Val 
    450                 455                 460                 


Glu Leu Gly Lys Asn Gln Ala Lys Phe Ser Leu Val Gly Ile Gly Gly 
465                 470                 475                 480 


Gln Asp Leu Asn Glu Gly Asn Arg Thr Leu Thr Leu Ala Leu Ile Trp 
                485                 490                 495     


Gln Leu Met Arg Arg Tyr Thr Leu Asn Ile Leu Glu Glu Ile Gly Gly 
            500                 505                 510         


Gly Gln Lys Val Asn Asp Asp Ile Ile Val Asn Trp Val Asn Glu Thr 
        515                 520                 525             


Leu Arg Glu Ala Lys Lys Ser Ser Ser Ile Ser Ser Phe Lys Asp Pro 
    530                 535                 540                 


Lys Ile Ser Thr Ser Leu Pro Val Leu Asp Leu Ile Asp Ala Ile Gln 
545                 550                 555                 560 


Pro Gly Ser Ile Asn Tyr Asp Leu Leu Lys Thr Glu Asn Leu Asn Asp 
                565                 570                 575     


Asp Glu Lys Leu Asn Asn Ala Lys Tyr Ala Ile Ser Met Ala Arg Lys 
            580                 585                 590         


Ile Gly Ala Arg Val Tyr Ala Leu Pro Glu Asp Leu Val Glu Val Asn 
        595                 600                 605             


Pro Lys Met Val Met Thr Val Phe Ala Cys Leu Met Gly Lys Gly Met 
    610                 615                 620                 


Lys Arg Val 
625         

<210>  3007
<211>  4030
<212>  DNA
<213>  Homo sapiens

<400>  3007
tttccagtgt ggatttcaaa gaatggagat cgttttcagc tataaaatgt ctcaagaaat     60

ttacgttcca tagaacgttt ctcaagaatc tactagagga tatgctcatt aaaacaagga    120

agtagacaaa gaaagtggat ggcatgtggt ccagaaatag gagattcagc ctagatggag    180

aataaaggag tccccagagt gatgagggaa tgggaatcag aggtgaagga gtgtgtcggg    240

agactggtgt ttcatgagaa gccttgagat tcctccggcc tcagatgacc aggcaccact    300

agatacagaa cactgtgctt tccttctcca agtcacttcc tgccttgtga ccacacaccc    360

aggcttgaca aagctgttct gcagatcaga aagaaggggt tcctggtcat acaccagtac    420

taccaaggac agcttttttc ctgcaagatc tgttacctaa agcaataaaa aatggccaga    480

ggatcagtgt ccgatgagga aatgatggag ctcagagaag cttttgccaa agttgatact    540

gatggcaatg gatacatcag cttcaatgag ttgaatgact tgttcaaggc tgcttgcttg    600

cctttgcctg ggtatagagt acgagaaatt acagaaaacc tgatggctac aggtgatctg    660

gaccaagatg gaaggatcag ctttgatgag tttatcaaga ttttccatgg cctaaaaagc    720

acagatgttg ccaagacctt tagaaaagca atcaataaga aggaagggat ttgtgcaatc    780

ggtggtactt cagagcagtc tagcgttggc acccaacact cctattcaga ggaagaaaag    840

tatgcctttg tcaactggat aaacaaagcc ctggaaaatg atcctgattg tcggcatgtc    900

atcccaatga acccaaacac gaatgatctc tttaatgctg ttggagatgg cattgtcctt    960

tgtaaaatga tcaacctgtc agtgccagac acaattgatg aaagaacaat caacaaaaag   1020

aagctaaccc ctttcaccat tcaggaaaat ctgaacttgg ctctgaactc tgcctcagcc   1080

atcgggtgcc atgtggtcaa cataggggct gaggacctga aggaggggaa gccttatctg   1140

gtcctgggac ttctgtggca agtcatcaag attgggttgt ttgctgacat tgaactcagc   1200

agaaatgaag ctctgattgc tcttttgaga gaaggtgaga gcctggagga tttgatgaaa   1260

ctctcccctg aagagctctt gctgaggtgg gctaattacc acctggaaaa tgcaggctgc   1320

aacaaaattg gcaacttcag tactgacatc aaggactcaa aagcttatta ccacctgctt   1380

gagcaggtgg ctccaaaagg agatgaagaa ggtgttcctg ctgttgttat tgacatgtca   1440

ggactgcggg agaaggatga catccagagg gcagaatgca tgctgcagca ggcggagagg   1500

ctgggctgcc ggcagtttgt cacagccaca gatgttgtcc gagggaaccc caagttgaac   1560

ttggctttta ttgccaacct ctttaacaga taccctgccc tgcacaaacc agagaaccag   1620

gacattgact ggggggctct tgaaggtgag acgagagaag agcggacatt taggaactgg   1680

atgaactccc tgggtgttaa ccctcgagtc aatcatttgt acagtgactt atcagatgcc   1740

ctggtcatct tccagctcta tgaaaagatc aaagttcctg ttgactggaa cagagtaaac   1800

aaaccgccat accccaaact gggaggcaat atgaagaagc ttgagaattg taactacgcg   1860

gtagaattgg ggaagaatca agcgaagttc tccctggttg gcatcggtgg acaagatctc   1920

aatgaaggaa accgcactct cacactggcc ttgatttggc agctaatgag aaggtataca   1980

ctgaatatcc tcgaagaaat tggtggtggc cagaaggtca atgatgacat tattgtcaac   2040

tgggtgaatg aaacattgag ggaagcaaag aaaagttcat ccatctctag tttcaaggac   2100

ccgaagatta gtacaagtct gcctgttctg gacctcatcg atgccatcca accaggttcc   2160

attaactatg accttctgaa gacagaaaat ctgaatgatg atgagaaact caacaatgca   2220

aaatatgcca tctctatggc ccgaaaaatt ggagcaagag tgtatgccct gccagaagac   2280

ctggttgaag tgaaccccaa aatggtcatg accgtgtttg cctgcctcat ggggaaagga   2340

atgaagaggg tgtgaggccc aatggggctg ggtgggaggc ggtgcactca ctcctgactg   2400

cccggcacag atgctccagg gatgattcaa gccattccaa agttcaactt ggtgacactc   2460

tataagattc caaaaagcac atattagtgc agccaagtag cctctcctgt atttaacaaa   2520

aagtgcttca ttctttgcag gaggcccaac ctcctatata taggtttcta ttcttgattt   2580

atttgcttct tcgaaaatct agaggaaaag aaagaagtta ttttccaggt acccttctcg   2640

cttttgccat tagccaagga tagaagctgc agtggtatta attttgatat aatctttcaa   2700

accagcttca tgtggcttcc cttttctttg ttcaagatga gggccaggag gggaaacatc   2760

acacctgccc taaaccctgt tcctggaggt cagcatttga tctgttgcaa gcccctcttt   2820

ctgtcccctc ttcctaccct gcctcccttg actttgctcc tcacactttt ggaaccatgc   2880

cttccggggg ggcccatctc ttctggccgt ccttgtctct gggccacttg gagtgtgtga   2940

taaatcagtc aagctgttga agtctcagga gtctctggta gcctgcagaa gtaagcctca   3000

tcatcagagc ctttcctcaa aactggagtc ccaaatgtca tcaggttttg ttttttttca   3060

gccactaaga acccctctgc ttttaactct agaatttggg cttggaccag atctaacatc   3120

ttgaatactc tgccctctag agccttcagc cttaatggaa ggttggatcc aaggagggtg   3180

taatggagca tcaagccact cggcggcagc atggagctat aactaagcat cctttagggt   3240

tctgcctctc caggcattta gccctcacat tagatctagt tactgtggta tggctaatac   3300

ctgtcaacat ttggaggcaa tcctaccttg cttttgcttc tagagcttag catatctgat   3360

tgttgtcagg ccatattatc aatgtttact tttttggtac tataaaagct ttctgccacc   3420

cctaaactcc aggggggaca atatgtgcca atcaatagca cccctactca catacacaca   3480

cacctagcca gctgtcaagg gcagaatgaa tctatgctgg ataagaaatg gtggaactgc   3540

gttatgaaga gctaatttac tggacaaaga attccaaagc aaaaccagaa cagtatgaat   3600

ttgagcaggt ctcataggtt gagcaatttc cccctaaacc aactgaaggc taaaaagcaa   3660

caggccattg tgaaccaatg caagacgccc tctatcatgg tgaaaagctc catcaatgag   3720

gtatcttctt tagtggtggt atgtaatgga acttagccat ttttcaaagc aattgaaatg   3780

cattgctctg gatctgttcc ttggcagtgg actcagaaag ccaacatgtg gctcctccca   3840

gcccataacc agtatttttg ctgcttctga atacaaattg gttggttttg acttcagatt   3900

gaacttactg tagcctcaga tgatttcccc cctccgcctc caggaagaaa gaatgttact   3960

gccttaataa aaaatgaaaa gagaatgatg ctcaaaatct ttccaaataa aatgttccct   4020

atattaggtg                                                          4030


<210>  3008
<211>  627
<212>  PRT
<213>  Homo sapiens

<400>  3008


Met Ala Arg Gly Ser Val Ser Asp Glu Glu Met Met Glu Leu Arg Glu 
1               5                   10                  15      


Ala Phe Ala Lys Val Asp Thr Asp Gly Asn Gly Tyr Ile Ser Phe Asn 
            20                  25                  30          


Glu Leu Asn Asp Leu Phe Lys Ala Ala Cys Leu Pro Leu Pro Gly Tyr 
        35                  40                  45              


Arg Val Arg Glu Ile Thr Glu Asn Leu Met Ala Thr Gly Asp Leu Asp 
    50                  55                  60                  


Gln Asp Gly Arg Ile Ser Phe Asp Glu Phe Ile Lys Ile Phe His Gly 
65                  70                  75                  80  


Leu Lys Ser Thr Asp Val Ala Lys Thr Phe Arg Lys Ala Ile Asn Lys 
                85                  90                  95      


Lys Glu Gly Ile Cys Ala Ile Gly Gly Thr Ser Glu Gln Ser Ser Val 
            100                 105                 110         


Gly Thr Gln His Ser Tyr Ser Glu Glu Glu Lys Tyr Ala Phe Val Asn 
        115                 120                 125             


Trp Ile Asn Lys Ala Leu Glu Asn Asp Pro Asp Cys Arg His Val Ile 
    130                 135                 140                 


Pro Met Asn Pro Asn Thr Asn Asp Leu Phe Asn Ala Val Gly Asp Gly 
145                 150                 155                 160 


Ile Val Leu Cys Lys Met Ile Asn Leu Ser Val Pro Asp Thr Ile Asp 
                165                 170                 175     


Glu Arg Thr Ile Asn Lys Lys Lys Leu Thr Pro Phe Thr Ile Gln Glu 
            180                 185                 190         


Asn Leu Asn Leu Ala Leu Asn Ser Ala Ser Ala Ile Gly Cys His Val 
        195                 200                 205             


Val Asn Ile Gly Ala Glu Asp Leu Lys Glu Gly Lys Pro Tyr Leu Val 
    210                 215                 220                 


Leu Gly Leu Leu Trp Gln Val Ile Lys Ile Gly Leu Phe Ala Asp Ile 
225                 230                 235                 240 


Glu Leu Ser Arg Asn Glu Ala Leu Ile Ala Leu Leu Arg Glu Gly Glu 
                245                 250                 255     


Ser Leu Glu Asp Leu Met Lys Leu Ser Pro Glu Glu Leu Leu Leu Arg 
            260                 265                 270         


Trp Ala Asn Tyr His Leu Glu Asn Ala Gly Cys Asn Lys Ile Gly Asn 
        275                 280                 285             


Phe Ser Thr Asp Ile Lys Asp Ser Lys Ala Tyr Tyr His Leu Leu Glu 
    290                 295                 300                 


Gln Val Ala Pro Lys Gly Asp Glu Glu Gly Val Pro Ala Val Val Ile 
305                 310                 315                 320 


Asp Met Ser Gly Leu Arg Glu Lys Asp Asp Ile Gln Arg Ala Glu Cys 
                325                 330                 335     


Met Leu Gln Gln Ala Glu Arg Leu Gly Cys Arg Gln Phe Val Thr Ala 
            340                 345                 350         


Thr Asp Val Val Arg Gly Asn Pro Lys Leu Asn Leu Ala Phe Ile Ala 
        355                 360                 365             


Asn Leu Phe Asn Arg Tyr Pro Ala Leu His Lys Pro Glu Asn Gln Asp 
    370                 375                 380                 


Ile Asp Trp Gly Ala Leu Glu Gly Glu Thr Arg Glu Glu Arg Thr Phe 
385                 390                 395                 400 


Arg Asn Trp Met Asn Ser Leu Gly Val Asn Pro Arg Val Asn His Leu 
                405                 410                 415     


Tyr Ser Asp Leu Ser Asp Ala Leu Val Ile Phe Gln Leu Tyr Glu Lys 
            420                 425                 430         


Ile Lys Val Pro Val Asp Trp Asn Arg Val Asn Lys Pro Pro Tyr Pro 
        435                 440                 445             


Lys Leu Gly Gly Asn Met Lys Lys Leu Glu Asn Cys Asn Tyr Ala Val 
    450                 455                 460                 


Glu Leu Gly Lys Asn Gln Ala Lys Phe Ser Leu Val Gly Ile Gly Gly 
465                 470                 475                 480 


Gln Asp Leu Asn Glu Gly Asn Arg Thr Leu Thr Leu Ala Leu Ile Trp 
                485                 490                 495     


Gln Leu Met Arg Arg Tyr Thr Leu Asn Ile Leu Glu Glu Ile Gly Gly 
            500                 505                 510         


Gly Gln Lys Val Asn Asp Asp Ile Ile Val Asn Trp Val Asn Glu Thr 
        515                 520                 525             


Leu Arg Glu Ala Lys Lys Ser Ser Ser Ile Ser Ser Phe Lys Asp Pro 
    530                 535                 540                 


Lys Ile Ser Thr Ser Leu Pro Val Leu Asp Leu Ile Asp Ala Ile Gln 
545                 550                 555                 560 


Pro Gly Ser Ile Asn Tyr Asp Leu Leu Lys Thr Glu Asn Leu Asn Asp 
                565                 570                 575     


Asp Glu Lys Leu Asn Asn Ala Lys Tyr Ala Ile Ser Met Ala Arg Lys 
            580                 585                 590         


Ile Gly Ala Arg Val Tyr Ala Leu Pro Glu Asp Leu Val Glu Val Asn 
        595                 600                 605             


Pro Lys Met Val Met Thr Val Phe Ala Cys Leu Met Gly Lys Gly Met 
    610                 615                 620                 


Lys Arg Val 
625         

<210>  3009
<211>  4094
<212>  DNA
<213>  Homo sapiens

<400>  3009
atagatacat cgtgtgtgtt tgcaaaaatg tgcgtgtttc tctggagatt tgagggggaa     60

agagcactag aaagagctca tctgatagat gcggaaatcc gaactcagaa agtaaactag    120

ggcgaatgag gaaagatcca gctctgacag aataatgagt tgtgcaaagt gaaggccaaa    180

tgacatcacc ggagatagca gtagttcaaa gaaagcaaag cagaggaatt gaactgctgc    240

aaaatgcacg agtctcaaac attgtctcag cagcagcatc atatcttaca aaagttgagg    300

aaatactgta tttccagctt aggaaactga agattcctcc ggcctcagat gaccaggcac    360

cactagatac agaacactgt gctttccttc tccaagtcac ttcctgcctt gtgaccacac    420

acccaggctt gacaaagctg ttctgcagat cagaaagaag gggttcctgg tcatacacca    480

gtactaccaa ggacagcttt tttcctgcaa gatctgttac ctaaagcaat aaaaaatggc    540

cagaggatca gtgtccgatg aggaaatgat ggagctcaga gaagcttttg ccaaagttga    600

tactgatggc aatggataca tcagcttcaa tgagttgaat gacttgttca aggctgcttg    660

cttgcctttg cctgggtata gagtacgaga aattacagaa aacctgatgg ctacaggtga    720

tctggaccaa gatggaagga tcagctttga tgagtttatc aagattttcc atggcctaaa    780

aagcacagat gttgccaaga cctttagaaa agcaatcaat aagaaggaag ggatttgtgc    840

aatcggtggt acttcagagc agtctagcgt tggcacccaa cactcctatt cagaggaaga    900

aaagtatgcc tttgtcaact ggataaacaa agccctggaa aatgatcctg attgtcggca    960

tgtcatccca atgaacccaa acacgaatga tctctttaat gctgttggag atggcattgt   1020

cctttgtaaa atgatcaacc tgtcagtgcc agacacaatt gatgaaagaa caatcaacaa   1080

aaagaagcta acccctttca ccattcagga aaatctgaac ttggctctga actctgcctc   1140

agccatcggg tgccatgtgg tcaacatagg ggctgaggac ctgaaggagg ggaagcctta   1200

tctggtcctg ggacttctgt ggcaagtcat caagattggg ttgtttgctg acattgaact   1260

cagcagaaat gaagctctga ttgctctttt gagagaaggt gagagcctgg aggatttgat   1320

gaaactctcc cctgaagagc tcttgctgag gtgggctaat taccacctgg aaaatgcagg   1380

ctgcaacaaa attggcaact tcagtactga catcaaggac tcaaaagctt attaccacct   1440

gcttgagcag gtggctccaa aaggagatga agaaggtgtt cctgctgttg ttattgacat   1500

gtcaggactg cgggagaagg atgacatcca gagggcagaa tgcatgctgc agcaggcgga   1560

gaggctgggc tgccggcagt ttgtcacagc cacagatgtt gtccgaggga accccaagtt   1620

gaacttggct tttattgcca acctctttaa cagataccct gccctgcaca aaccagagaa   1680

ccaggacatt gactgggggg ctcttgaagg tgagacgaga gaagagcgga catttaggaa   1740

ctggatgaac tccctgggtg ttaaccctcg agtcaatcat ttgtacagtg acttatcaga   1800

tgccctggtc atcttccagc tctatgaaaa gatcaaagtt cctgttgact ggaacagagt   1860

aaacaaaccg ccatacccca aactgggagg caatatgaag aagcttgaga attgtaacta   1920

cgcggtagaa ttggggaaga atcaagcgaa gttctccctg gttggcatcg gtggacaaga   1980

tctcaatgaa ggaaaccgca ctctcacact ggccttgatt tggcagctaa tgagaaggta   2040

tacactgaat atcctcgaag aaattggtgg tggccagaag gtcaatgatg acattattgt   2100

caactgggtg aatgaaacat tgagggaagc aaagaaaagt tcatccatct ctagtttcaa   2160

ggacccgaag attagtacaa gtctgcctgt tctggacctc atcgatgcca tccaaccagg   2220

ttccattaac tatgaccttc tgaagacaga aaatctgaat gatgatgaga aactcaacaa   2280

tgcaaaatat gccatctcta tggcccgaaa aattggagca agagtgtatg ccctgccaga   2340

agacctggtt gaagtgaacc ccaaaatggt catgaccgtg tttgcctgcc tcatggggaa   2400

aggaatgaag agggtgtgag gcccaatggg gctgggtggg aggcggtgca ctcactcctg   2460

actgcccggc acagatgctc cagggatgat tcaagccatt ccaaagttca acttggtgac   2520

actctataag attccaaaaa gcacatatta gtgcagccaa gtagcctctc ctgtatttaa   2580

caaaaagtgc ttcattcttt gcaggaggcc caacctccta tatataggtt tctattcttg   2640

atttatttgc ttcttcgaaa atctagagga aaagaaagaa gttattttcc aggtaccctt   2700

ctcgcttttg ccattagcca aggatagaag ctgcagtggt attaattttg atataatctt   2760

tcaaaccagc ttcatgtggc ttcccttttc tttgttcaag atgagggcca ggaggggaaa   2820

catcacacct gccctaaacc ctgttcctgg aggtcagcat ttgatctgtt gcaagcccct   2880

ctttctgtcc cctcttccta ccctgcctcc cttgactttg ctcctcacac ttttggaacc   2940

atgccttccg ggggggccca tctcttctgg ccgtccttgt ctctgggcca cttggagtgt   3000

gtgataaatc agtcaagctg ttgaagtctc aggagtctct ggtagcctgc agaagtaagc   3060

ctcatcatca gagcctttcc tcaaaactgg agtcccaaat gtcatcaggt tttgtttttt   3120

ttcagccact aagaacccct ctgcttttaa ctctagaatt tgggcttgga ccagatctaa   3180

catcttgaat actctgccct ctagagcctt cagccttaat ggaaggttgg atccaaggag   3240

ggtgtaatgg agcatcaagc cactcggcgg cagcatggag ctataactaa gcatccttta   3300

gggttctgcc tctccaggca tttagccctc acattagatc tagttactgt ggtatggcta   3360

atacctgtca acatttggag gcaatcctac cttgcttttg cttctagagc ttagcatatc   3420

tgattgttgt caggccatat tatcaatgtt tacttttttg gtactataaa agctttctgc   3480

cacccctaaa ctccaggggg gacaatatgt gccaatcaat agcaccccta ctcacataca   3540

cacacaccta gccagctgtc aagggcagaa tgaatctatg ctggataaga aatggtggaa   3600

ctgcgttatg aagagctaat ttactggaca aagaattcca aagcaaaacc agaacagtat   3660

gaatttgagc aggtctcata ggttgagcaa tttcccccta aaccaactga aggctaaaaa   3720

gcaacaggcc attgtgaacc aatgcaagac gccctctatc atggtgaaaa gctccatcaa   3780

tgaggtatct tctttagtgg tggtatgtaa tggaacttag ccatttttca aagcaattga   3840

aatgcattgc tctggatctg ttccttggca gtggactcag aaagccaaca tgtggctcct   3900

cccagcccat aaccagtatt tttgctgctt ctgaatacaa attggttggt tttgacttca   3960

gattgaactt actgtagcct cagatgattt cccccctccg cctccaggaa gaaagaatgt   4020

tactgcctta ataaaaaatg aaaagagaat gatgctcaaa atctttccaa ataaaatgtt   4080

ccctatatta ggtg                                                     4094


<210>  3010
<211>  627
<212>  PRT
<213>  Homo sapiens

<400>  3010


Met Ala Arg Gly Ser Val Ser Asp Glu Glu Met Met Glu Leu Arg Glu 
1               5                   10                  15      


Ala Phe Ala Lys Val Asp Thr Asp Gly Asn Gly Tyr Ile Ser Phe Asn 
            20                  25                  30          


Glu Leu Asn Asp Leu Phe Lys Ala Ala Cys Leu Pro Leu Pro Gly Tyr 
        35                  40                  45              


Arg Val Arg Glu Ile Thr Glu Asn Leu Met Ala Thr Gly Asp Leu Asp 
    50                  55                  60                  


Gln Asp Gly Arg Ile Ser Phe Asp Glu Phe Ile Lys Ile Phe His Gly 
65                  70                  75                  80  


Leu Lys Ser Thr Asp Val Ala Lys Thr Phe Arg Lys Ala Ile Asn Lys 
                85                  90                  95      


Lys Glu Gly Ile Cys Ala Ile Gly Gly Thr Ser Glu Gln Ser Ser Val 
            100                 105                 110         


Gly Thr Gln His Ser Tyr Ser Glu Glu Glu Lys Tyr Ala Phe Val Asn 
        115                 120                 125             


Trp Ile Asn Lys Ala Leu Glu Asn Asp Pro Asp Cys Arg His Val Ile 
    130                 135                 140                 


Pro Met Asn Pro Asn Thr Asn Asp Leu Phe Asn Ala Val Gly Asp Gly 
145                 150                 155                 160 


Ile Val Leu Cys Lys Met Ile Asn Leu Ser Val Pro Asp Thr Ile Asp 
                165                 170                 175     


Glu Arg Thr Ile Asn Lys Lys Lys Leu Thr Pro Phe Thr Ile Gln Glu 
            180                 185                 190         


Asn Leu Asn Leu Ala Leu Asn Ser Ala Ser Ala Ile Gly Cys His Val 
        195                 200                 205             


Val Asn Ile Gly Ala Glu Asp Leu Lys Glu Gly Lys Pro Tyr Leu Val 
    210                 215                 220                 


Leu Gly Leu Leu Trp Gln Val Ile Lys Ile Gly Leu Phe Ala Asp Ile 
225                 230                 235                 240 


Glu Leu Ser Arg Asn Glu Ala Leu Ile Ala Leu Leu Arg Glu Gly Glu 
                245                 250                 255     


Ser Leu Glu Asp Leu Met Lys Leu Ser Pro Glu Glu Leu Leu Leu Arg 
            260                 265                 270         


Trp Ala Asn Tyr His Leu Glu Asn Ala Gly Cys Asn Lys Ile Gly Asn 
        275                 280                 285             


Phe Ser Thr Asp Ile Lys Asp Ser Lys Ala Tyr Tyr His Leu Leu Glu 
    290                 295                 300                 


Gln Val Ala Pro Lys Gly Asp Glu Glu Gly Val Pro Ala Val Val Ile 
305                 310                 315                 320 


Asp Met Ser Gly Leu Arg Glu Lys Asp Asp Ile Gln Arg Ala Glu Cys 
                325                 330                 335     


Met Leu Gln Gln Ala Glu Arg Leu Gly Cys Arg Gln Phe Val Thr Ala 
            340                 345                 350         


Thr Asp Val Val Arg Gly Asn Pro Lys Leu Asn Leu Ala Phe Ile Ala 
        355                 360                 365             


Asn Leu Phe Asn Arg Tyr Pro Ala Leu His Lys Pro Glu Asn Gln Asp 
    370                 375                 380                 


Ile Asp Trp Gly Ala Leu Glu Gly Glu Thr Arg Glu Glu Arg Thr Phe 
385                 390                 395                 400 


Arg Asn Trp Met Asn Ser Leu Gly Val Asn Pro Arg Val Asn His Leu 
                405                 410                 415     


Tyr Ser Asp Leu Ser Asp Ala Leu Val Ile Phe Gln Leu Tyr Glu Lys 
            420                 425                 430         


Ile Lys Val Pro Val Asp Trp Asn Arg Val Asn Lys Pro Pro Tyr Pro 
        435                 440                 445             


Lys Leu Gly Gly Asn Met Lys Lys Leu Glu Asn Cys Asn Tyr Ala Val 
    450                 455                 460                 


Glu Leu Gly Lys Asn Gln Ala Lys Phe Ser Leu Val Gly Ile Gly Gly 
465                 470                 475                 480 


Gln Asp Leu Asn Glu Gly Asn Arg Thr Leu Thr Leu Ala Leu Ile Trp 
                485                 490                 495     


Gln Leu Met Arg Arg Tyr Thr Leu Asn Ile Leu Glu Glu Ile Gly Gly 
            500                 505                 510         


Gly Gln Lys Val Asn Asp Asp Ile Ile Val Asn Trp Val Asn Glu Thr 
        515                 520                 525             


Leu Arg Glu Ala Lys Lys Ser Ser Ser Ile Ser Ser Phe Lys Asp Pro 
    530                 535                 540                 


Lys Ile Ser Thr Ser Leu Pro Val Leu Asp Leu Ile Asp Ala Ile Gln 
545                 550                 555                 560 


Pro Gly Ser Ile Asn Tyr Asp Leu Leu Lys Thr Glu Asn Leu Asn Asp 
                565                 570                 575     


Asp Glu Lys Leu Asn Asn Ala Lys Tyr Ala Ile Ser Met Ala Arg Lys 
            580                 585                 590         


Ile Gly Ala Arg Val Tyr Ala Leu Pro Glu Asp Leu Val Glu Val Asn 
        595                 600                 605             


Pro Lys Met Val Met Thr Val Phe Ala Cys Leu Met Gly Lys Gly Met 
    610                 615                 620                 


Lys Arg Val 
625         

<210>  3011
<211>  3948
<212>  DNA
<213>  Homo sapiens

<400>  3011
ggtgttgatg aacctgtgtg tgcagtcata gatacatcgt gtgtgtttgc aaaaatggcg     60

aatgaggaaa gatccagctc tgacagaata atgagttgtg caaagtgaag gccaaatgac    120

atcaccggag atagcagtag ttcaaagaaa gcaaagcaga ggaattgaac tgctgcaaaa    180

tgcacgattc ctccggcctc agatgaccag gcaccactag atacagaaca ctgtgctttc    240

cttctccaag tcacttcctg ccttgtgacc acacacccag gcttgacaaa gctgttctgc    300

agatcagaaa gaaggggttc ctggtcatac accagtacta ccaaggacag cttttttcct    360

gcaagatctg ttacctaaag caataaaaaa tggccagagg atcagtgtcc gatgaggaaa    420

tgatggagct cagagaagct tttgccaaag ttgatactga tggcaatgga tacatcagct    480

tcaatgagtt gaatgacttg ttcaaggctg cttgcttgcc tttgcctggg tatagagtac    540

gagaaattac agaaaacctg atggctacag gtgatctgga ccaagatgga aggatcagct    600

ttgatgagtt tatcaagatt ttccatggcc taaaaagcac agatgttgcc aagaccttta    660

gaaaagcaat caataagaag gaagggattt gtgcaatcgg tggtacttca gagcagtcta    720

gcgttggcac ccaacactcc tattcagagg aagaaaagta tgcctttgtc aactggataa    780

acaaagccct ggaaaatgat cctgattgtc ggcatgtcat cccaatgaac ccaaacacga    840

atgatctctt taatgctgtt ggagatggca ttgtcctttg taaaatgatc aacctgtcag    900

tgccagacac aattgatgaa agaacaatca acaaaaagaa gctaacccct ttcaccattc    960

aggaaaatct gaacttggct ctgaactctg cctcagccat cgggtgccat gtggtcaaca   1020

taggggctga ggacctgaag gaggggaagc cttatctggt cctgggactt ctgtggcaag   1080

tcatcaagat tgggttgttt gctgacattg aactcagcag aaatgaagct ctgattgctc   1140

ttttgagaga aggtgagagc ctggaggatt tgatgaaact ctcccctgaa gagctcttgc   1200

tgaggtgggc taattaccac ctggaaaatg caggctgcaa caaaattggc aacttcagta   1260

ctgacatcaa ggactcaaaa gcttattacc acctgcttga gcaggtggct ccaaaaggag   1320

atgaagaagg tgttcctgct gttgttattg acatgtcagg actgcgggag aaggatgaca   1380

tccagagggc agaatgcatg ctgcagcagg cggagaggct gggctgccgg cagtttgtca   1440

cagccacaga tgttgtccga gggaacccca agttgaactt ggcttttatt gccaacctct   1500

ttaacagata ccctgccctg cacaaaccag agaaccagga cattgactgg ggggctcttg   1560

aaggtgagac gagagaagag cggacattta ggaactggat gaactccctg ggtgttaacc   1620

ctcgagtcaa tcatttgtac agtgacttat cagatgccct ggtcatcttc cagctctatg   1680

aaaagatcaa agttcctgtt gactggaaca gagtaaacaa accgccatac cccaaactgg   1740

gaggcaatat gaagaagctt gagaattgta actacgcggt agaattgggg aagaatcaag   1800

cgaagttctc cctggttggc atcggtggac aagatctcaa tgaaggaaac cgcactctca   1860

cactggcctt gatttggcag ctaatgagaa ggtatacact gaatatcctc gaagaaattg   1920

gtggtggcca gaaggtcaat gatgacatta ttgtcaactg ggtgaatgaa acattgaggg   1980

aagcaaagaa aagttcatcc atctctagtt tcaaggaccc gaagattagt acaagtctgc   2040

ctgttctgga cctcatcgat gccatccaac caggttccat taactatgac cttctgaaga   2100

cagaaaatct gaatgatgat gagaaactca acaatgcaaa atatgccatc tctatggccc   2160

gaaaaattgg agcaagagtg tatgccctgc cagaagacct ggttgaagtg aaccccaaaa   2220

tggtcatgac cgtgtttgcc tgcctcatgg ggaaaggaat gaagagggtg tgaggcccaa   2280

tggggctggg tgggaggcgg tgcactcact cctgactgcc cggcacagat gctccaggga   2340

tgattcaagc cattccaaag ttcaacttgg tgacactcta taagattcca aaaagcacat   2400

attagtgcag ccaagtagcc tctcctgtat ttaacaaaaa gtgcttcatt ctttgcagga   2460

ggcccaacct cctatatata ggtttctatt cttgatttat ttgcttcttc gaaaatctag   2520

aggaaaagaa agaagttatt ttccaggtac ccttctcgct tttgccatta gccaaggata   2580

gaagctgcag tggtattaat tttgatataa tctttcaaac cagcttcatg tggcttccct   2640

tttctttgtt caagatgagg gccaggaggg gaaacatcac acctgcccta aaccctgttc   2700

ctggaggtca gcatttgatc tgttgcaagc ccctctttct gtcccctctt cctaccctgc   2760

ctcccttgac tttgctcctc acacttttgg aaccatgcct tccggggggg cccatctctt   2820

ctggccgtcc ttgtctctgg gccacttgga gtgtgtgata aatcagtcaa gctgttgaag   2880

tctcaggagt ctctggtagc ctgcagaagt aagcctcatc atcagagcct ttcctcaaaa   2940

ctggagtccc aaatgtcatc aggttttgtt ttttttcagc cactaagaac ccctctgctt   3000

ttaactctag aatttgggct tggaccagat ctaacatctt gaatactctg ccctctagag   3060

ccttcagcct taatggaagg ttggatccaa ggagggtgta atggagcatc aagccactcg   3120

gcggcagcat ggagctataa ctaagcatcc tttagggttc tgcctctcca ggcatttagc   3180

cctcacatta gatctagtta ctgtggtatg gctaatacct gtcaacattt ggaggcaatc   3240

ctaccttgct tttgcttcta gagcttagca tatctgattg ttgtcaggcc atattatcaa   3300

tgtttacttt tttggtacta taaaagcttt ctgccacccc taaactccag gggggacaat   3360

atgtgccaat caatagcacc cctactcaca tacacacaca cctagccagc tgtcaagggc   3420

agaatgaatc tatgctggat aagaaatggt ggaactgcgt tatgaagagc taatttactg   3480

gacaaagaat tccaaagcaa aaccagaaca gtatgaattt gagcaggtct cataggttga   3540

gcaatttccc cctaaaccaa ctgaaggcta aaaagcaaca ggccattgtg aaccaatgca   3600

agacgccctc tatcatggtg aaaagctcca tcaatgaggt atcttcttta gtggtggtat   3660

gtaatggaac ttagccattt ttcaaagcaa ttgaaatgca ttgctctgga tctgttcctt   3720

ggcagtggac tcagaaagcc aacatgtggc tcctcccagc ccataaccag tatttttgct   3780

gcttctgaat acaaattggt tggttttgac ttcagattga acttactgta gcctcagatg   3840

atttcccccc tccgcctcca ggaagaaaga atgttactgc cttaataaaa aatgaaaaga   3900

gaatgatgct caaaatcttt ccaaataaaa tgttccctat attaggtg                3948


<210>  3012
<211>  627
<212>  PRT
<213>  Homo sapiens

<400>  3012


Met Ala Arg Gly Ser Val Ser Asp Glu Glu Met Met Glu Leu Arg Glu 
1               5                   10                  15      


Ala Phe Ala Lys Val Asp Thr Asp Gly Asn Gly Tyr Ile Ser Phe Asn 
            20                  25                  30          


Glu Leu Asn Asp Leu Phe Lys Ala Ala Cys Leu Pro Leu Pro Gly Tyr 
        35                  40                  45              


Arg Val Arg Glu Ile Thr Glu Asn Leu Met Ala Thr Gly Asp Leu Asp 
    50                  55                  60                  


Gln Asp Gly Arg Ile Ser Phe Asp Glu Phe Ile Lys Ile Phe His Gly 
65                  70                  75                  80  


Leu Lys Ser Thr Asp Val Ala Lys Thr Phe Arg Lys Ala Ile Asn Lys 
                85                  90                  95      


Lys Glu Gly Ile Cys Ala Ile Gly Gly Thr Ser Glu Gln Ser Ser Val 
            100                 105                 110         


Gly Thr Gln His Ser Tyr Ser Glu Glu Glu Lys Tyr Ala Phe Val Asn 
        115                 120                 125             


Trp Ile Asn Lys Ala Leu Glu Asn Asp Pro Asp Cys Arg His Val Ile 
    130                 135                 140                 


Pro Met Asn Pro Asn Thr Asn Asp Leu Phe Asn Ala Val Gly Asp Gly 
145                 150                 155                 160 


Ile Val Leu Cys Lys Met Ile Asn Leu Ser Val Pro Asp Thr Ile Asp 
                165                 170                 175     


Glu Arg Thr Ile Asn Lys Lys Lys Leu Thr Pro Phe Thr Ile Gln Glu 
            180                 185                 190         


Asn Leu Asn Leu Ala Leu Asn Ser Ala Ser Ala Ile Gly Cys His Val 
        195                 200                 205             


Val Asn Ile Gly Ala Glu Asp Leu Lys Glu Gly Lys Pro Tyr Leu Val 
    210                 215                 220                 


Leu Gly Leu Leu Trp Gln Val Ile Lys Ile Gly Leu Phe Ala Asp Ile 
225                 230                 235                 240 


Glu Leu Ser Arg Asn Glu Ala Leu Ile Ala Leu Leu Arg Glu Gly Glu 
                245                 250                 255     


Ser Leu Glu Asp Leu Met Lys Leu Ser Pro Glu Glu Leu Leu Leu Arg 
            260                 265                 270         


Trp Ala Asn Tyr His Leu Glu Asn Ala Gly Cys Asn Lys Ile Gly Asn 
        275                 280                 285             


Phe Ser Thr Asp Ile Lys Asp Ser Lys Ala Tyr Tyr His Leu Leu Glu 
    290                 295                 300                 


Gln Val Ala Pro Lys Gly Asp Glu Glu Gly Val Pro Ala Val Val Ile 
305                 310                 315                 320 


Asp Met Ser Gly Leu Arg Glu Lys Asp Asp Ile Gln Arg Ala Glu Cys 
                325                 330                 335     


Met Leu Gln Gln Ala Glu Arg Leu Gly Cys Arg Gln Phe Val Thr Ala 
            340                 345                 350         


Thr Asp Val Val Arg Gly Asn Pro Lys Leu Asn Leu Ala Phe Ile Ala 
        355                 360                 365             


Asn Leu Phe Asn Arg Tyr Pro Ala Leu His Lys Pro Glu Asn Gln Asp 
    370                 375                 380                 


Ile Asp Trp Gly Ala Leu Glu Gly Glu Thr Arg Glu Glu Arg Thr Phe 
385                 390                 395                 400 


Arg Asn Trp Met Asn Ser Leu Gly Val Asn Pro Arg Val Asn His Leu 
                405                 410                 415     


Tyr Ser Asp Leu Ser Asp Ala Leu Val Ile Phe Gln Leu Tyr Glu Lys 
            420                 425                 430         


Ile Lys Val Pro Val Asp Trp Asn Arg Val Asn Lys Pro Pro Tyr Pro 
        435                 440                 445             


Lys Leu Gly Gly Asn Met Lys Lys Leu Glu Asn Cys Asn Tyr Ala Val 
    450                 455                 460                 


Glu Leu Gly Lys Asn Gln Ala Lys Phe Ser Leu Val Gly Ile Gly Gly 
465                 470                 475                 480 


Gln Asp Leu Asn Glu Gly Asn Arg Thr Leu Thr Leu Ala Leu Ile Trp 
                485                 490                 495     


Gln Leu Met Arg Arg Tyr Thr Leu Asn Ile Leu Glu Glu Ile Gly Gly 
            500                 505                 510         


Gly Gln Lys Val Asn Asp Asp Ile Ile Val Asn Trp Val Asn Glu Thr 
        515                 520                 525             


Leu Arg Glu Ala Lys Lys Ser Ser Ser Ile Ser Ser Phe Lys Asp Pro 
    530                 535                 540                 


Lys Ile Ser Thr Ser Leu Pro Val Leu Asp Leu Ile Asp Ala Ile Gln 
545                 550                 555                 560 


Pro Gly Ser Ile Asn Tyr Asp Leu Leu Lys Thr Glu Asn Leu Asn Asp 
                565                 570                 575     


Asp Glu Lys Leu Asn Asn Ala Lys Tyr Ala Ile Ser Met Ala Arg Lys 
            580                 585                 590         


Ile Gly Ala Arg Val Tyr Ala Leu Pro Glu Asp Leu Val Glu Val Asn 
        595                 600                 605             


Pro Lys Met Val Met Thr Val Phe Ala Cys Leu Met Gly Lys Gly Met 
    610                 615                 620                 


Lys Arg Val 
625         

<210>  3013
<211>  4111
<212>  DNA
<213>  Homo sapiens

<400>  3013
gggcgccggg aggggcaggc ccagcccacg gtgcagcgcg cgcggagccc tcgccttcct     60

ccgacgcact gtggggctgc aggggaagct gcgggccgtg ggggccggag gagaagccgg    120

ctccacgcgc agctgctggc gaatgaggaa agatccagct ctgacagaat aatgagttgt    180

gcaaagtgaa ggccaaatga catcaccgga gatagcagta gttcaaagaa agcaaagcag    240

aggaattgaa ctgctgcaaa atgcacgagt ctcaaacatt gtctcagcag cagcatcata    300

tcttacaaaa gttgaggaaa tactgtattt ccagcttagg aaactgaaga ttcctccggc    360

ctcagatgac caggcaccac tagatacaga acactgtgct ttccttctcc aagtcacttc    420

ctgccttgtg accacacacc caggcttgac aaagctgttc tgcagatcag aaagaagggg    480

ttcctggtca tacaccagta ctaccaagga cagctttttt cctgcaagat ctgttaccta    540

aagcaataaa aaatggccag aggatcagtg tccgatgagg aaatgatgga gctcagagaa    600

gcttttgcca aagttgatac tgatggcaat ggatacatca gcttcaatga gttgaatgac    660

ttgttcaagg ctgcttgctt gcctttgcct gggtatagag tacgagaaat tacagaaaac    720

ctgatggcta caggtgatct ggaccaagat ggaaggatca gctttgatga gtttatcaag    780

attttccatg gcctaaaaag cacagatgtt gccaagacct ttagaaaagc aatcaataag    840

aaggaaggga tttgtgcaat cggtggtact tcagagcagt ctagcgttgg cacccaacac    900

tcctattcag aggaagaaaa gtatgccttt gtcaactgga taaacaaagc cctggaaaat    960

gatcctgatt gtcggcatgt catcccaatg aacccaaaca cgaatgatct ctttaatgct   1020

gttggagatg gcattgtcct ttgtaaaatg atcaacctgt cagtgccaga cacaattgat   1080

gaaagaacaa tcaacaaaaa gaagctaacc cctttcacca ttcaggaaaa tctgaacttg   1140

gctctgaact ctgcctcagc catcgggtgc catgtggtca acataggggc tgaggacctg   1200

aaggagggga agccttatct ggtcctggga cttctgtggc aagtcatcaa gattgggttg   1260

tttgctgaca ttgaactcag cagaaatgaa gctctgattg ctcttttgag agaaggtgag   1320

agcctggagg atttgatgaa actctcccct gaagagctct tgctgaggtg ggctaattac   1380

cacctggaaa atgcaggctg caacaaaatt ggcaacttca gtactgacat caaggactca   1440

aaagcttatt accacctgct tgagcaggtg gctccaaaag gagatgaaga aggtgttcct   1500

gctgttgtta ttgacatgtc aggactgcgg gagaaggatg acatccagag ggcagaatgc   1560

atgctgcagc aggcggagag gctgggctgc cggcagtttg tcacagccac agatgttgtc   1620

cgagggaacc ccaagttgaa cttggctttt attgccaacc tctttaacag ataccctgcc   1680

ctgcacaaac cagagaacca ggacattgac tggggggctc ttgaaggtga gacgagagaa   1740

gagcggacat ttaggaactg gatgaactcc ctgggtgtta accctcgagt caatcatttg   1800

tacagtgact tatcagatgc cctggtcatc ttccagctct atgaaaagat caaagttcct   1860

gttgactgga acagagtaaa caaaccgcca taccccaaac tgggaggcaa tatgaagaag   1920

cttgagaatt gtaactacgc ggtagaattg gggaagaatc aagcgaagtt ctccctggtt   1980

ggcatcggtg gacaagatct caatgaagga aaccgcactc tcacactggc cttgatttgg   2040

cagctaatga gaaggtatac actgaatatc ctcgaagaaa ttggtggtgg ccagaaggtc   2100

aatgatgaca ttattgtcaa ctgggtgaat gaaacattga gggaagcaaa gaaaagttca   2160

tccatctcta gtttcaagga cccgaagatt agtacaagtc tgcctgttct ggacctcatc   2220

gatgccatcc aaccaggttc cattaactat gaccttctga agacagaaaa tctgaatgat   2280

gatgagaaac tcaacaatgc aaaatatgcc atctctatgg cccgaaaaat tggagcaaga   2340

gtgtatgccc tgccagaaga cctggttgaa gtgaacccca aaatggtcat gaccgtgttt   2400

gcctgcctca tggggaaagg aatgaagagg gtgtgaggcc caatggggct gggtgggagg   2460

cggtgcactc actcctgact gcccggcaca gatgctccag ggatgattca agccattcca   2520

aagttcaact tggtgacact ctataagatt ccaaaaagca catattagtg cagccaagta   2580

gcctctcctg tatttaacaa aaagtgcttc attctttgca ggaggcccaa cctcctatat   2640

ataggtttct attcttgatt tatttgcttc ttcgaaaatc tagaggaaaa gaaagaagtt   2700

attttccagg tacccttctc gcttttgcca ttagccaagg atagaagctg cagtggtatt   2760

aattttgata taatctttca aaccagcttc atgtggcttc ccttttcttt gttcaagatg   2820

agggccagga ggggaaacat cacacctgcc ctaaaccctg ttcctggagg tcagcatttg   2880

atctgttgca agcccctctt tctgtcccct cttcctaccc tgcctccctt gactttgctc   2940

ctcacacttt tggaaccatg ccttccgggg gggcccatct cttctggccg tccttgtctc   3000

tgggccactt ggagtgtgtg ataaatcagt caagctgttg aagtctcagg agtctctggt   3060

agcctgcaga agtaagcctc atcatcagag cctttcctca aaactggagt cccaaatgtc   3120

atcaggtttt gttttttttc agccactaag aacccctctg cttttaactc tagaatttgg   3180

gcttggacca gatctaacat cttgaatact ctgccctcta gagccttcag ccttaatgga   3240

aggttggatc caaggagggt gtaatggagc atcaagccac tcggcggcag catggagcta   3300

taactaagca tcctttaggg ttctgcctct ccaggcattt agccctcaca ttagatctag   3360

ttactgtggt atggctaata cctgtcaaca tttggaggca atcctacctt gcttttgctt   3420

ctagagctta gcatatctga ttgttgtcag gccatattat caatgtttac ttttttggta   3480

ctataaaagc tttctgccac ccctaaactc caggggggac aatatgtgcc aatcaatagc   3540

acccctactc acatacacac acacctagcc agctgtcaag ggcagaatga atctatgctg   3600

gataagaaat ggtggaactg cgttatgaag agctaattta ctggacaaag aattccaaag   3660

caaaaccaga acagtatgaa tttgagcagg tctcataggt tgagcaattt ccccctaaac   3720

caactgaagg ctaaaaagca acaggccatt gtgaaccaat gcaagacgcc ctctatcatg   3780

gtgaaaagct ccatcaatga ggtatcttct ttagtggtgg tatgtaatgg aacttagcca   3840

tttttcaaag caattgaaat gcattgctct ggatctgttc cttggcagtg gactcagaaa   3900

gccaacatgt ggctcctccc agcccataac cagtattttt gctgcttctg aatacaaatt   3960

ggttggtttt gacttcagat tgaacttact gtagcctcag atgatttccc ccctccgcct   4020

ccaggaagaa agaatgttac tgccttaata aaaaatgaaa agagaatgat gctcaaaatc   4080

tttccaaata aaatgttccc tatattaggt g                                  4111


<210>  3014
<211>  627
<212>  PRT
<213>  Homo sapiens

<400>  3014


Met Ala Arg Gly Ser Val Ser Asp Glu Glu Met Met Glu Leu Arg Glu 
1               5                   10                  15      


Ala Phe Ala Lys Val Asp Thr Asp Gly Asn Gly Tyr Ile Ser Phe Asn 
            20                  25                  30          


Glu Leu Asn Asp Leu Phe Lys Ala Ala Cys Leu Pro Leu Pro Gly Tyr 
        35                  40                  45              


Arg Val Arg Glu Ile Thr Glu Asn Leu Met Ala Thr Gly Asp Leu Asp 
    50                  55                  60                  


Gln Asp Gly Arg Ile Ser Phe Asp Glu Phe Ile Lys Ile Phe His Gly 
65                  70                  75                  80  


Leu Lys Ser Thr Asp Val Ala Lys Thr Phe Arg Lys Ala Ile Asn Lys 
                85                  90                  95      


Lys Glu Gly Ile Cys Ala Ile Gly Gly Thr Ser Glu Gln Ser Ser Val 
            100                 105                 110         


Gly Thr Gln His Ser Tyr Ser Glu Glu Glu Lys Tyr Ala Phe Val Asn 
        115                 120                 125             


Trp Ile Asn Lys Ala Leu Glu Asn Asp Pro Asp Cys Arg His Val Ile 
    130                 135                 140                 


Pro Met Asn Pro Asn Thr Asn Asp Leu Phe Asn Ala Val Gly Asp Gly 
145                 150                 155                 160 


Ile Val Leu Cys Lys Met Ile Asn Leu Ser Val Pro Asp Thr Ile Asp 
                165                 170                 175     


Glu Arg Thr Ile Asn Lys Lys Lys Leu Thr Pro Phe Thr Ile Gln Glu 
            180                 185                 190         


Asn Leu Asn Leu Ala Leu Asn Ser Ala Ser Ala Ile Gly Cys His Val 
        195                 200                 205             


Val Asn Ile Gly Ala Glu Asp Leu Lys Glu Gly Lys Pro Tyr Leu Val 
    210                 215                 220                 


Leu Gly Leu Leu Trp Gln Val Ile Lys Ile Gly Leu Phe Ala Asp Ile 
225                 230                 235                 240 


Glu Leu Ser Arg Asn Glu Ala Leu Ile Ala Leu Leu Arg Glu Gly Glu 
                245                 250                 255     


Ser Leu Glu Asp Leu Met Lys Leu Ser Pro Glu Glu Leu Leu Leu Arg 
            260                 265                 270         


Trp Ala Asn Tyr His Leu Glu Asn Ala Gly Cys Asn Lys Ile Gly Asn 
        275                 280                 285             


Phe Ser Thr Asp Ile Lys Asp Ser Lys Ala Tyr Tyr His Leu Leu Glu 
    290                 295                 300                 


Gln Val Ala Pro Lys Gly Asp Glu Glu Gly Val Pro Ala Val Val Ile 
305                 310                 315                 320 


Asp Met Ser Gly Leu Arg Glu Lys Asp Asp Ile Gln Arg Ala Glu Cys 
                325                 330                 335     


Met Leu Gln Gln Ala Glu Arg Leu Gly Cys Arg Gln Phe Val Thr Ala 
            340                 345                 350         


Thr Asp Val Val Arg Gly Asn Pro Lys Leu Asn Leu Ala Phe Ile Ala 
        355                 360                 365             


Asn Leu Phe Asn Arg Tyr Pro Ala Leu His Lys Pro Glu Asn Gln Asp 
    370                 375                 380                 


Ile Asp Trp Gly Ala Leu Glu Gly Glu Thr Arg Glu Glu Arg Thr Phe 
385                 390                 395                 400 


Arg Asn Trp Met Asn Ser Leu Gly Val Asn Pro Arg Val Asn His Leu 
                405                 410                 415     


Tyr Ser Asp Leu Ser Asp Ala Leu Val Ile Phe Gln Leu Tyr Glu Lys 
            420                 425                 430         


Ile Lys Val Pro Val Asp Trp Asn Arg Val Asn Lys Pro Pro Tyr Pro 
        435                 440                 445             


Lys Leu Gly Gly Asn Met Lys Lys Leu Glu Asn Cys Asn Tyr Ala Val 
    450                 455                 460                 


Glu Leu Gly Lys Asn Gln Ala Lys Phe Ser Leu Val Gly Ile Gly Gly 
465                 470                 475                 480 


Gln Asp Leu Asn Glu Gly Asn Arg Thr Leu Thr Leu Ala Leu Ile Trp 
                485                 490                 495     


Gln Leu Met Arg Arg Tyr Thr Leu Asn Ile Leu Glu Glu Ile Gly Gly 
            500                 505                 510         


Gly Gln Lys Val Asn Asp Asp Ile Ile Val Asn Trp Val Asn Glu Thr 
        515                 520                 525             


Leu Arg Glu Ala Lys Lys Ser Ser Ser Ile Ser Ser Phe Lys Asp Pro 
    530                 535                 540                 


Lys Ile Ser Thr Ser Leu Pro Val Leu Asp Leu Ile Asp Ala Ile Gln 
545                 550                 555                 560 


Pro Gly Ser Ile Asn Tyr Asp Leu Leu Lys Thr Glu Asn Leu Asn Asp 
                565                 570                 575     


Asp Glu Lys Leu Asn Asn Ala Lys Tyr Ala Ile Ser Met Ala Arg Lys 
            580                 585                 590         


Ile Gly Ala Arg Val Tyr Ala Leu Pro Glu Asp Leu Val Glu Val Asn 
        595                 600                 605             


Pro Lys Met Val Met Thr Val Phe Ala Cys Leu Met Gly Lys Gly Met 
    610                 615                 620                 


Lys Arg Val 
625         

<210>  3015
<211>  4380
<212>  DNA
<213>  Homo sapiens

<400>  3015
gggacaggcg aggcgaggcg ggcgccggga ggggcaggcc cagcccacgg tgcagcgcgc     60

gcggagccct cgccttcctc cgacgcactg tggggctgca ggggaagctg cgggccgtgg    120

gggccggagg agaagccggc tccacgcgca gctgctggcg aatgaggaaa gatccagctc    180

tgacagaata atgagttgtg caaagtgaag gccaaatgac atcaccggag atagcagtag    240

ttcaaagaaa gcaaagcaga ggaattgaac tgctgcaaaa tgcacggaat acctgaggct    300

gggcaattta tgaagaaaca gacacatttg gctcatggtt cagcaggctg tacaagaagc    360

atggtgccag catctgcttg tggtgagggt ccaggctgct ttcactcatg gcggaaggca    420

aaggggagct ggtgtgcaga gatcacacag caacagcaga agcaagagag agggagtctc    480

aaacattgtc tcagcagcag catcatatct tacaaaagtt gaggaaatac tgtatttcca    540

gcttaggaaa ctgaagggaa tgggaatcag aggtgaagga gtgtgtcggg agactggtgt    600

ttcatgagaa gccttgagat tcctccggcc tcagatgacc aggcaccact agatacagaa    660

cactgtgctt tccttctcca agtcacttcc tgccttgtga ccacacaccc aggcttgaca    720

aagctgttct gcagatcaga aagaaggggt tcctggtcat acaccagtac taccaaggac    780

agcttttttc ctgcaagatc tgttacctaa agcaataaaa aatggccaga ggatcagtgt    840

ccgatgagga aatgatggag ctcagagaag cttttgccaa agttgatact gatggcaatg    900

gatacatcag cttcaatgag ttgaatgact tgttcaaggc tgcttgcttg cctttgcctg    960

ggtatagagt acgagaaatt acagaaaacc tgatggctac aggtgatctg gaccaagatg   1020

gaaggatcag ctttgatgag tttatcaaga ttttccatgg cctaaaaagc acagatgttg   1080

ccaagacctt tagaaaagca atcaataaga aggaagggat ttgtgcaatc ggtggtactt   1140

cagagcagtc tagcgttggc acccaacact cctattcaga ggaagaaaag tatgcctttg   1200

tcaactggat aaacaaagcc ctggaaaatg atcctgattg tcggcatgtc atcccaatga   1260

acccaaacac gaatgatctc tttaatgctg ttggagatgg cattgtcctt tgtaaaatga   1320

tcaacctgtc agtgccagac acaattgatg aaagaacaat caacaaaaag aagctaaccc   1380

ctttcaccat tcaggaaaat ctgaacttgg ctctgaactc tgcctcagcc atcgggtgcc   1440

atgtggtcaa cataggggct gaggacctga aggaggggaa gccttatctg gtcctgggac   1500

ttctgtggca agtcatcaag attgggttgt ttgctgacat tgaactcagc agaaatgaag   1560

ctctgattgc tcttttgaga gaaggtgaga gcctggagga tttgatgaaa ctctcccctg   1620

aagagctctt gctgaggtgg gctaattacc acctggaaaa tgcaggctgc aacaaaattg   1680

gcaacttcag tactgacatc aaggactcaa aagcttatta ccacctgctt gagcaggtgg   1740

ctccaaaagg agatgaagaa ggtgttcctg ctgttgttat tgacatgtca ggactgcggg   1800

agaaggatga catccagagg gcagaatgca tgctgcagca ggcggagagg ctgggctgcc   1860

ggcagtttgt cacagccaca gatgttgtcc gagggaaccc caagttgaac ttggctttta   1920

ttgccaacct ctttaacaga taccctgccc tgcacaaacc agagaaccag gacattgact   1980

ggggggctct tgaaggtgag acgagagaag agcggacatt taggaactgg atgaactccc   2040

tgggtgttaa ccctcgagtc aatcatttgt acagtgactt atcagatgcc ctggtcatct   2100

tccagctcta tgaaaagatc aaagttcctg ttgactggaa cagagtaaac aaaccgccat   2160

accccaaact gggaggcaat atgaagaagc ttgagaattg taactacgcg gtagaattgg   2220

ggaagaatca agcgaagttc tccctggttg gcatcggtgg acaagatctc aatgaaggaa   2280

accgcactct cacactggcc ttgatttggc agctaatgag aaggtataca ctgaatatcc   2340

tcgaagaaat tggtggtggc cagaaggtca atgatgacat tattgtcaac tgggtgaatg   2400

aaacattgag ggaagcaaag aaaagttcat ccatctctag tttcaaggac ccgaagatta   2460

gtacaagtct gcctgttctg gacctcatcg atgccatcca accaggttcc attaactatg   2520

accttctgaa gacagaaaat ctgaatgatg atgagaaact caacaatgca aaatatgcca   2580

tctctatggc ccgaaaaatt ggagcaagag tgtatgccct gccagaagac ctggttgaag   2640

tgaaccccaa aatggtcatg accgtgtttg cctgcctcat ggggaaagga atgaagaggg   2700

tgtgaggccc aatggggctg ggtgggaggc ggtgcactca ctcctgactg cccggcacag   2760

atgctccagg gatgattcaa gccattccaa agttcaactt ggtgacactc tataagattc   2820

caaaaagcac atattagtgc agccaagtag cctctcctgt atttaacaaa aagtgcttca   2880

ttctttgcag gaggcccaac ctcctatata taggtttcta ttcttgattt atttgcttct   2940

tcgaaaatct agaggaaaag aaagaagtta ttttccaggt acccttctcg cttttgccat   3000

tagccaagga tagaagctgc agtggtatta attttgatat aatctttcaa accagcttca   3060

tgtggcttcc cttttctttg ttcaagatga gggccaggag gggaaacatc acacctgccc   3120

taaaccctgt tcctggaggt cagcatttga tctgttgcaa gcccctcttt ctgtcccctc   3180

ttcctaccct gcctcccttg actttgctcc tcacactttt ggaaccatgc cttccggggg   3240

ggcccatctc ttctggccgt ccttgtctct gggccacttg gagtgtgtga taaatcagtc   3300

aagctgttga agtctcagga gtctctggta gcctgcagaa gtaagcctca tcatcagagc   3360

ctttcctcaa aactggagtc ccaaatgtca tcaggttttg ttttttttca gccactaaga   3420

acccctctgc ttttaactct agaatttggg cttggaccag atctaacatc ttgaatactc   3480

tgccctctag agccttcagc cttaatggaa ggttggatcc aaggagggtg taatggagca   3540

tcaagccact cggcggcagc atggagctat aactaagcat cctttagggt tctgcctctc   3600

caggcattta gccctcacat tagatctagt tactgtggta tggctaatac ctgtcaacat   3660

ttggaggcaa tcctaccttg cttttgcttc tagagcttag catatctgat tgttgtcagg   3720

ccatattatc aatgtttact tttttggtac tataaaagct ttctgccacc cctaaactcc   3780

aggggggaca atatgtgcca atcaatagca cccctactca catacacaca cacctagcca   3840

gctgtcaagg gcagaatgaa tctatgctgg ataagaaatg gtggaactgc gttatgaaga   3900

gctaatttac tggacaaaga attccaaagc aaaaccagaa cagtatgaat ttgagcaggt   3960

ctcataggtt gagcaatttc cccctaaacc aactgaaggc taaaaagcaa caggccattg   4020

tgaaccaatg caagacgccc tctatcatgg tgaaaagctc catcaatgag gtatcttctt   4080

tagtggtggt atgtaatgga acttagccat ttttcaaagc aattgaaatg cattgctctg   4140

gatctgttcc ttggcagtgg actcagaaag ccaacatgtg gctcctccca gcccataacc   4200

agtatttttg ctgcttctga atacaaattg gttggttttg acttcagatt gaacttactg   4260

tagcctcaga tgatttcccc cctccgcctc caggaagaaa gaatgttact gccttaataa   4320

aaaatgaaaa gagaatgatg ctcaaaatct ttccaaataa aatgttccct atattaggtg   4380


<210>  3016
<211>  627
<212>  PRT
<213>  Homo sapiens

<400>  3016


Met Ala Arg Gly Ser Val Ser Asp Glu Glu Met Met Glu Leu Arg Glu 
1               5                   10                  15      


Ala Phe Ala Lys Val Asp Thr Asp Gly Asn Gly Tyr Ile Ser Phe Asn 
            20                  25                  30          


Glu Leu Asn Asp Leu Phe Lys Ala Ala Cys Leu Pro Leu Pro Gly Tyr 
        35                  40                  45              


Arg Val Arg Glu Ile Thr Glu Asn Leu Met Ala Thr Gly Asp Leu Asp 
    50                  55                  60                  


Gln Asp Gly Arg Ile Ser Phe Asp Glu Phe Ile Lys Ile Phe His Gly 
65                  70                  75                  80  


Leu Lys Ser Thr Asp Val Ala Lys Thr Phe Arg Lys Ala Ile Asn Lys 
                85                  90                  95      


Lys Glu Gly Ile Cys Ala Ile Gly Gly Thr Ser Glu Gln Ser Ser Val 
            100                 105                 110         


Gly Thr Gln His Ser Tyr Ser Glu Glu Glu Lys Tyr Ala Phe Val Asn 
        115                 120                 125             


Trp Ile Asn Lys Ala Leu Glu Asn Asp Pro Asp Cys Arg His Val Ile 
    130                 135                 140                 


Pro Met Asn Pro Asn Thr Asn Asp Leu Phe Asn Ala Val Gly Asp Gly 
145                 150                 155                 160 


Ile Val Leu Cys Lys Met Ile Asn Leu Ser Val Pro Asp Thr Ile Asp 
                165                 170                 175     


Glu Arg Thr Ile Asn Lys Lys Lys Leu Thr Pro Phe Thr Ile Gln Glu 
            180                 185                 190         


Asn Leu Asn Leu Ala Leu Asn Ser Ala Ser Ala Ile Gly Cys His Val 
        195                 200                 205             


Val Asn Ile Gly Ala Glu Asp Leu Lys Glu Gly Lys Pro Tyr Leu Val 
    210                 215                 220                 


Leu Gly Leu Leu Trp Gln Val Ile Lys Ile Gly Leu Phe Ala Asp Ile 
225                 230                 235                 240 


Glu Leu Ser Arg Asn Glu Ala Leu Ile Ala Leu Leu Arg Glu Gly Glu 
                245                 250                 255     


Ser Leu Glu Asp Leu Met Lys Leu Ser Pro Glu Glu Leu Leu Leu Arg 
            260                 265                 270         


Trp Ala Asn Tyr His Leu Glu Asn Ala Gly Cys Asn Lys Ile Gly Asn 
        275                 280                 285             


Phe Ser Thr Asp Ile Lys Asp Ser Lys Ala Tyr Tyr His Leu Leu Glu 
    290                 295                 300                 


Gln Val Ala Pro Lys Gly Asp Glu Glu Gly Val Pro Ala Val Val Ile 
305                 310                 315                 320 


Asp Met Ser Gly Leu Arg Glu Lys Asp Asp Ile Gln Arg Ala Glu Cys 
                325                 330                 335     


Met Leu Gln Gln Ala Glu Arg Leu Gly Cys Arg Gln Phe Val Thr Ala 
            340                 345                 350         


Thr Asp Val Val Arg Gly Asn Pro Lys Leu Asn Leu Ala Phe Ile Ala 
        355                 360                 365             


Asn Leu Phe Asn Arg Tyr Pro Ala Leu His Lys Pro Glu Asn Gln Asp 
    370                 375                 380                 


Ile Asp Trp Gly Ala Leu Glu Gly Glu Thr Arg Glu Glu Arg Thr Phe 
385                 390                 395                 400 


Arg Asn Trp Met Asn Ser Leu Gly Val Asn Pro Arg Val Asn His Leu 
                405                 410                 415     


Tyr Ser Asp Leu Ser Asp Ala Leu Val Ile Phe Gln Leu Tyr Glu Lys 
            420                 425                 430         


Ile Lys Val Pro Val Asp Trp Asn Arg Val Asn Lys Pro Pro Tyr Pro 
        435                 440                 445             


Lys Leu Gly Gly Asn Met Lys Lys Leu Glu Asn Cys Asn Tyr Ala Val 
    450                 455                 460                 


Glu Leu Gly Lys Asn Gln Ala Lys Phe Ser Leu Val Gly Ile Gly Gly 
465                 470                 475                 480 


Gln Asp Leu Asn Glu Gly Asn Arg Thr Leu Thr Leu Ala Leu Ile Trp 
                485                 490                 495     


Gln Leu Met Arg Arg Tyr Thr Leu Asn Ile Leu Glu Glu Ile Gly Gly 
            500                 505                 510         


Gly Gln Lys Val Asn Asp Asp Ile Ile Val Asn Trp Val Asn Glu Thr 
        515                 520                 525             


Leu Arg Glu Ala Lys Lys Ser Ser Ser Ile Ser Ser Phe Lys Asp Pro 
    530                 535                 540                 


Lys Ile Ser Thr Ser Leu Pro Val Leu Asp Leu Ile Asp Ala Ile Gln 
545                 550                 555                 560 


Pro Gly Ser Ile Asn Tyr Asp Leu Leu Lys Thr Glu Asn Leu Asn Asp 
                565                 570                 575     


Asp Glu Lys Leu Asn Asn Ala Lys Tyr Ala Ile Ser Met Ala Arg Lys 
            580                 585                 590         


Ile Gly Ala Arg Val Tyr Ala Leu Pro Glu Asp Leu Val Glu Val Asn 
        595                 600                 605             


Pro Lys Met Val Met Thr Val Phe Ala Cys Leu Met Gly Lys Gly Met 
    610                 615                 620                 


Lys Arg Val 
625         

<210>  3017
<211>  2076
<212>  DNA
<213>  Homo sapiens

<400>  3017
aaaatctttt tctttcctgg ctgatgattt gtcattctag tcacttcctg ccttgtgacc     60

acacacccag gcttgacaaa gctgttctgc agatcagaaa gaaggggttc ctggtcatac    120

accagtacta ccaaggacag cttttttcct gcaagatctg ttacctaaag caataaaaaa    180

tggccagagg atcagtgtcc gatgaggaaa tgatggagct cagagaagct tttgccaaag    240

ttggtgagta gacctggtac cccaaattgc atcattctct tcttcactga gtagcttcag    300

ggtagattca atgaaatggg aacatgagca aaatttcaga gatgacaaga aaccagtagt    360

atttgtttag aggagctggg agaacttatt tttgaaaaat atgcttcaat aaaatgactt    420

tctctatcaa aacatggaat atggactcta ctcttacata gtttgttcct ggaaatggtt    480

tgtaagtctc atcttttata tcttgtcttc tgttttgctg tttccttgat tttaatacca    540

tcacatactt tctcttactc tttatcacta aacctgtggt ttccttaaga gtttctataa    600

gagttctttg tggaaacaga ggtaccttat agaaattatg actcttttac tgtggatgtt    660

gaaagtaatg ctggtgcccc tattcagtag caacagtcat cttgtgagat tctgactctt    720

ccctgggatc atgccttaat gtctgaatga tagcctctct cgtcccttca ccttccatct    780

agtcttccct cacctctcta aaagctgttg cctgaatcgt cctgaagctt cagtatattg    840

tgtacattac agatactgat ggcaatggat acatcagctt caatgagttg aatgacttgt    900

tcaaggctgc ttgcttgcct ttgcctgggt atagagtacg agaaattaca gaaaacctga    960

tggctacagg tgatctggac caagatggaa ggatcagctt tgatgagttt atcaaggtga   1020

gtaccatgca gaatacaagg agacacattt gaaacttgga acttgaattc tgttttaaaa   1080

aatatccaga aagacattcc ttacctcctt gcttcgacat tacatattct ttcctttgtg   1140

attttcttga tcactgcttg agtttctaaa gatacattat atttttgcag attttccatg   1200

gcctaaaaag cacagatgtt gccaagacct ttagaaaagc aatcaataag aaggaaggga   1260

tttgtgcaat cggtggtact tcagagcagt ctagcgttgg cacccaacac tcctattcag   1320

gtaggctcaa ctcctgggtt ggagcaggat ttcaggatta cagattctaa acttggtatt   1380

caaacctaag ggatgtaaac aaagacagaa gcaaacacag ctttatggat gactcccaat   1440

tttcctgtga ctaagtgggt cagttctggg tacataatat aggagcagtc ctagctctgg   1500

gtagggtcca atacaaaatg atttgatcag catttaaaca atcattaaag gctgcccaga   1560

ttcctttcta aatcttatgg acaaaattag ctactcaagc ttctatcttt aaacttcatg   1620

ataattttta acacctgcta agtgatcaaa aaattatgtt ttcattgatt tggaataaat   1680

ttgtaaattt attccgaagg ctgccatcca acagccataa tggaaacttc caacaggcca   1740

aacagtatag ttgttgcaac atttccaaaa ctgaattatt caaaacgtta gttgatctta   1800

aagataaact catgaggccg ggcacagtgg ctcacgcgtg taatcccagc actttgggag   1860

gccaaggcgg gtggatcacc tgaggtcagg agttaaagac tagcctgggc aacatggtga   1920

aaccccgttc tactgggtgc agtggcgcat gcctgtaatc tcatcgactc gggaagctga   1980

gacaggagaa tcgcttgagc ccaggaggca gaggttgcag tgagccgaga ttgcaccatt   2040

gcactccagc ctggcgacag aacaagactc tgtctc                             2076


<210>  3018
<211>  50
<212>  PRT
<213>  Homo sapiens

<400>  3018


Met Ile Cys His Ser Ser His Phe Leu Pro Cys Asp His Thr Pro Arg 
1               5                   10                  15      


Leu Asp Lys Ala Val Leu Gln Ile Arg Lys Lys Gly Phe Leu Val Ile 
            20                  25                  30          


His Gln Tyr Tyr Gln Gly Gln Leu Phe Ser Cys Lys Ile Cys Tyr Leu 
        35                  40                  45              


Lys Gln 
    50  

<210>  3019
<211>  616
<212>  DNA
<213>  Homo sapiens

<400>  3019
ggttcctggt catacaccag tactaccaag gacagctttt ttcctgcaag agggcagcag     60

tgatgcacag gaaaagggaa attactcaag cactgtttct cagcaagact gtcgcttttc    120

tgagaagaaa acacctagaa agcgcctcag attcccatag ctgaattatg agaggatctg    180

ttacctaaag caataaaaaa tggccagagg atcagtgtcc gatgaggaaa tgatggagct    240

cagagaagct tttgccaaag ttggtgagta gacctggtac cccaaattgc atcattctct    300

tcttcactga gtagcttcag ggtagattca atgaaatggg aacatgagca aaatttcaga    360

gatgacaaga aaccagtagt atttgtttag aggagctggg agaacttatt tttgaaaaat    420

atgcttcaat aaaatgactt tctctatcaa aacatggaat atggactcta ctcttacata    480

gtttgttcct ggaaatggtt tgtaagtctc atcttttata tcttgtcttc tgttttgctg    540

tttccttgat tttaatacca tcacatactt tctcttactc tttatcacta aacctgtggt    600

ttccttaaga gtttct                                                    616


<210>  3020
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  3020


Met Val Cys Lys Ser His Leu Leu Tyr Leu Val Phe Cys Phe Ala Val 
1               5                   10                  15      


Ser Leu Ile Leu Ile Pro Ser His Thr Phe Ser Tyr Ser Leu Ser Leu 
            20                  25                  30          


Asn Leu Trp Phe Pro 
        35          

<210>  3021
<211>  1687
<212>  DNA
<213>  Homo sapiens

<400>  3021
ggaccccggt tgctagggtg tgtctccttg gcctcctaga gggtggggat ccgtggtgct     60

tcttcgggaa cagcctcctg caggaagacc ctcgctggac ctttacctcg ctgcctagat    120

tccgaggaaa aggagatagg agacgaaaag ccagttggtt tggaaagcgg ccgattatcc    180

taaagggtag tgtgggagtc cagcacttcc atgcccctct ttgggtacta cggaagggag    240

atttccagca tcgtgtggaa catatgacca gggagtacac cttgagcgct tgtgtgcagt    300

tatcttttgg cggattatga aaaacagcac ttattattca ttaaaatgca aaagccccca    360

ctgcttcttc gaagaccctt acctccaaaa ttcactaagc tgtctttaca tgagaaaaaa    420

acccatacag ctaaaactgg taaaattgag tcactacatg tagcattcac tgaagatgaa    480

accacttcca ttaaaatgga tagaactcgt tttcctgatg ttttaagaaa tcaatcacta    540

acacctatca atatccaaaa tatctttctt gatcactgtg tacaagaaag agtgactgca    600

atttcatcac cccagaaatc tactaagcat gtccgtgagc agattccaga tactgctact    660

ggttccatat tttttccaca ttgtaattca gcttctactc gaatttttgg gaaacaaaca    720

aacaaaatgg aaagttcaag aaagtttaaa actatgaaag atgtttatac tgaaaaaagg    780

ctagaaaaca ttttaattct ttcttccaag ttttccaaac ctaaaagtac tcctggctca    840

gttatcgctc aaaaacttga gaaaatgcac cctaagcatc aacctttacc agagagtcca    900

ggctatactt atcagcacat ctcgagagac ttaagtgcaa cagtgccaag ccctccacct    960

atgactgtat ctatgaaacc agaaggacag tggcctgaac attttaaatc aactgctaca   1020

ttgacactaa gagttactga atttccaggt tttgtttcct tgccaacacc agttttacca   1080

agaaaacctc acaggcagtc tgtgatagaa actcttgtaa cagaaaatgg aaatatagaa   1140

agtgtcccaa agcaaatccc accaagacca cctgaaggtc tcaccaaaac tgaaaaaata   1200

gaatcagaga tacacgttgt acgtggtgaa ggttttaaga ctgttgcagc aacacgatat   1260

gaaacaataa cagccatgac caacctggcc atagtaaact gtcaagtata tgggagaaat   1320

gcacttaatc tgaaggtatg ctagatcttt ttaatgacag tgccctcctg tattatcaat   1380

tatttttgct ttaaatttcc caatatagat tagtttccat ggtattgagg ggaatggctt   1440

ttttatccta aattgtccag acttaacacc tttggctttc cagttgatat atcttaattt   1500

atcatttaat gatcttcatt actttcccac agaaatatta tgtcttaaaa atttacaaat   1560

actgaaattg agaaataatc ctatcaaaga aattccttct gaaattcaac aacttgagtt   1620

ccttagaatt ttcaccattg cttttaattt aattactgtt cttccaattg ggtaaggttg   1680

atggtct                                                             1687


<210>  3022
<211>  332
<212>  PRT
<213>  Homo sapiens

<400>  3022


Met Gln Lys Pro Pro Leu Leu Leu Arg Arg Pro Leu Pro Pro Lys Phe 
1               5                   10                  15      


Thr Lys Leu Ser Leu His Glu Lys Lys Thr His Thr Ala Lys Thr Gly 
            20                  25                  30          


Lys Ile Glu Ser Leu His Val Ala Phe Thr Glu Asp Glu Thr Thr Ser 
        35                  40                  45              


Ile Lys Met Asp Arg Thr Arg Phe Pro Asp Val Leu Arg Asn Gln Ser 
    50                  55                  60                  


Leu Thr Pro Ile Asn Ile Gln Asn Ile Phe Leu Asp His Cys Val Gln 
65                  70                  75                  80  


Glu Arg Val Thr Ala Ile Ser Ser Pro Gln Lys Ser Thr Lys His Val 
                85                  90                  95      


Arg Glu Gln Ile Pro Asp Thr Ala Thr Gly Ser Ile Phe Phe Pro His 
            100                 105                 110         


Cys Asn Ser Ala Ser Thr Arg Ile Phe Gly Lys Gln Thr Asn Lys Met 
        115                 120                 125             


Glu Ser Ser Arg Lys Phe Lys Thr Met Lys Asp Val Tyr Thr Glu Lys 
    130                 135                 140                 


Arg Leu Glu Asn Ile Leu Ile Leu Ser Ser Lys Phe Ser Lys Pro Lys 
145                 150                 155                 160 


Ser Thr Pro Gly Ser Val Ile Ala Gln Lys Leu Glu Lys Met His Pro 
                165                 170                 175     


Lys His Gln Pro Leu Pro Glu Ser Pro Gly Tyr Thr Tyr Gln His Ile 
            180                 185                 190         


Ser Arg Asp Leu Ser Ala Thr Val Pro Ser Pro Pro Pro Met Thr Val 
        195                 200                 205             


Ser Met Lys Pro Glu Gly Gln Trp Pro Glu His Phe Lys Ser Thr Ala 
    210                 215                 220                 


Thr Leu Thr Leu Arg Val Thr Glu Phe Pro Gly Phe Val Ser Leu Pro 
225                 230                 235                 240 


Thr Pro Val Leu Pro Arg Lys Pro His Arg Gln Ser Val Ile Glu Thr 
                245                 250                 255     


Leu Val Thr Glu Asn Gly Asn Ile Glu Ser Val Pro Lys Gln Ile Pro 
            260                 265                 270         


Pro Arg Pro Pro Glu Gly Leu Thr Lys Thr Glu Lys Ile Glu Ser Glu 
        275                 280                 285             


Ile His Val Val Arg Gly Glu Gly Phe Lys Thr Val Ala Ala Thr Arg 
    290                 295                 300                 


Tyr Glu Thr Ile Thr Ala Met Thr Asn Leu Ala Ile Val Asn Cys Gln 
305                 310                 315                 320 


Val Tyr Gly Arg Asn Ala Leu Asn Leu Lys Val Cys 
                325                 330         

<210>  3023
<211>  1863
<212>  DNA
<213>  Homo sapiens

<400>  3023
ggaccccggt tgctagggtg tgtctccttg gcctcctaga gggtggggat ccgtggtgct     60

tcttcgggaa cagcctcctg caggaagacc ctcgctggac ctttacctcg ctgcctagat    120

tccgaggaaa aggagatagg agacgaaaag ccagttggtt tggaaagcgg ccgattatcc    180

taaagggtag tgtgggagtc cagcacttcc atgcccctct ttgggtacta cggaagggag    240

atttccagca tcgtgtggaa catatgacca gggagtacac cttgagcgct tgtgtgcagt    300

tatcttttgg cggattatga aaaacagcac ttattattca ttaaaatgca aaagccccca    360

ctgcttcttc gaagaccctt acctccaaaa ttcactaagc tgtctttaca tgagaaaaaa    420

acccatacag ctaaaactgg taaaattgag tcactacatg tagcattcac tgaagatgaa    480

accacttcca ttaaaatgga tagaactcgt tttcctgatg ttttaagaaa tcaatcacta    540

acacctatca atatccaaaa tatctttctt gatcactgtg tacaagaaag agtgactgca    600

atttcatcac cccagaaatc tactaagcat gtccgtgagc agattccaga tactgctact    660

ggttccatat tttttccaca ttgtaattca gcttctactc gaatttttgg gaaacaaaca    720

aacaaaatgg aaagttcaag aaagtttaaa actatgaaag atgtttatac tgaaaaaagg    780

ctagaaaaca ttttaattct ttcttccaag ttttccaaac ctaaaagtac tcctggctca    840

gttatcgctc aaaaacttga gaaaatgcac cctaagcatc aacctttacc agagagtcca    900

ggctatactt atcagcacat ctcgagagac ttaagtgcaa cagtgccaag ccctccacct    960

atgactgtat ctatgaaacc agaaggacag tggcctgaac attttaaatc aactgctaca   1020

ttgacactaa gagttactga atttccaggt tttgtttcct tgccaacacc agttttacca   1080

agaaaacctc acaggcagtc tgtgatagaa actcttgtaa cagaaaatgg aaatatagaa   1140

agtgtcccaa agcaaatccc accaagacca cctgaaggtc tcaccaaaac tgaaaaaata   1200

gaatcagaga tacacgttgt acgtggtgaa ggttttaaga ctgttgcagc aacacgatat   1260

gaaacaataa cagccatgac caacctggcc atagtaaact gtcaagtata tgggagaaat   1320

gcacttaatc tgaagggctt ttttatccta aattgtccag acttaacacc tttggctttc   1380

cagttgatat atcttaattt atcatttaat gatcttcatt actttcccac agaaatatta   1440

tgtcttaaaa atttacaaat actgaaattg agaaataatc ctatcaaaga aattccttct   1500

gaaattcaac aacttgagtt ccttagaatt ttcaccattg cttttaattt aattactgtt   1560

cttccaattg ggttattttc cttgtcttat cttgaagaac ttgatgtttc ctataatgaa   1620

cttactttta ttccaaatga aattcagaaa ctcagatcac ttgaaaaact gactgttgat   1680

gggaatgaac tgagtttttt cccccatgga attttgaagc ttaacctgac aaaaattcag   1740

tttgagaata atttcactca tccttgtttt tggagagata attatttgaa taatccacaa   1800

caacttactc aaattatttc tttgttcatt gtccaaaata aactacataa attttatgat   1860

aag                                                                 1863


<210>  3024
<211>  505
<212>  PRT
<213>  Homo sapiens

<400>  3024


Met Gln Lys Pro Pro Leu Leu Leu Arg Arg Pro Leu Pro Pro Lys Phe 
1               5                   10                  15      


Thr Lys Leu Ser Leu His Glu Lys Lys Thr His Thr Ala Lys Thr Gly 
            20                  25                  30          


Lys Ile Glu Ser Leu His Val Ala Phe Thr Glu Asp Glu Thr Thr Ser 
        35                  40                  45              


Ile Lys Met Asp Arg Thr Arg Phe Pro Asp Val Leu Arg Asn Gln Ser 
    50                  55                  60                  


Leu Thr Pro Ile Asn Ile Gln Asn Ile Phe Leu Asp His Cys Val Gln 
65                  70                  75                  80  


Glu Arg Val Thr Ala Ile Ser Ser Pro Gln Lys Ser Thr Lys His Val 
                85                  90                  95      


Arg Glu Gln Ile Pro Asp Thr Ala Thr Gly Ser Ile Phe Phe Pro His 
            100                 105                 110         


Cys Asn Ser Ala Ser Thr Arg Ile Phe Gly Lys Gln Thr Asn Lys Met 
        115                 120                 125             


Glu Ser Ser Arg Lys Phe Lys Thr Met Lys Asp Val Tyr Thr Glu Lys 
    130                 135                 140                 


Arg Leu Glu Asn Ile Leu Ile Leu Ser Ser Lys Phe Ser Lys Pro Lys 
145                 150                 155                 160 


Ser Thr Pro Gly Ser Val Ile Ala Gln Lys Leu Glu Lys Met His Pro 
                165                 170                 175     


Lys His Gln Pro Leu Pro Glu Ser Pro Gly Tyr Thr Tyr Gln His Ile 
            180                 185                 190         


Ser Arg Asp Leu Ser Ala Thr Val Pro Ser Pro Pro Pro Met Thr Val 
        195                 200                 205             


Ser Met Lys Pro Glu Gly Gln Trp Pro Glu His Phe Lys Ser Thr Ala 
    210                 215                 220                 


Thr Leu Thr Leu Arg Val Thr Glu Phe Pro Gly Phe Val Ser Leu Pro 
225                 230                 235                 240 


Thr Pro Val Leu Pro Arg Lys Pro His Arg Gln Ser Val Ile Glu Thr 
                245                 250                 255     


Leu Val Thr Glu Asn Gly Asn Ile Glu Ser Val Pro Lys Gln Ile Pro 
            260                 265                 270         


Pro Arg Pro Pro Glu Gly Leu Thr Lys Thr Glu Lys Ile Glu Ser Glu 
        275                 280                 285             


Ile His Val Val Arg Gly Glu Gly Phe Lys Thr Val Ala Ala Thr Arg 
    290                 295                 300                 


Tyr Glu Thr Ile Thr Ala Met Thr Asn Leu Ala Ile Val Asn Cys Gln 
305                 310                 315                 320 


Val Tyr Gly Arg Asn Ala Leu Asn Leu Lys Gly Phe Phe Ile Leu Asn 
                325                 330                 335     


Cys Pro Asp Leu Thr Pro Leu Ala Phe Gln Leu Ile Tyr Leu Asn Leu 
            340                 345                 350         


Ser Phe Asn Asp Leu His Tyr Phe Pro Thr Glu Ile Leu Cys Leu Lys 
        355                 360                 365             


Asn Leu Gln Ile Leu Lys Leu Arg Asn Asn Pro Ile Lys Glu Ile Pro 
    370                 375                 380                 


Ser Glu Ile Gln Gln Leu Glu Phe Leu Arg Ile Phe Thr Ile Ala Phe 
385                 390                 395                 400 


Asn Leu Ile Thr Val Leu Pro Ile Gly Leu Phe Ser Leu Ser Tyr Leu 
                405                 410                 415     


Glu Glu Leu Asp Val Ser Tyr Asn Glu Leu Thr Phe Ile Pro Asn Glu 
            420                 425                 430         


Ile Gln Lys Leu Arg Ser Leu Glu Lys Leu Thr Val Asp Gly Asn Glu 
        435                 440                 445             


Leu Ser Phe Phe Pro His Gly Ile Leu Lys Leu Asn Leu Thr Lys Ile 
    450                 455                 460                 


Gln Phe Glu Asn Asn Phe Thr His Pro Cys Phe Trp Arg Asp Asn Tyr 
465                 470                 475                 480 


Leu Asn Asn Pro Gln Gln Leu Thr Gln Ile Ile Ser Leu Phe Ile Val 
                485                 490                 495     


Gln Asn Lys Leu His Lys Phe Tyr Asp 
            500                 505 

<210>  3025
<211>  568
<212>  DNA
<213>  Homo sapiens

<400>  3025
gatcctcatc atttattgca ctcagctgag agaacagaaa aatgtcattt cacattctgt     60

tgcataggaa agaaaaggca tatatgattc ctgcctaaga atgcaagctc agtggatttt    120

ctggacgtaa gatagaaaag aatacttatt gttataacct aaatgagctt atggcacctg    180

taaccactat cagattgtta tcatcttcaa aagacacatt ggtctgacat ctggcattta    240

aaagaaatgt aaatctttgg tcaaggaaat ttcaaatgag ggagagctaa tgatgtatga    300

taaatagcaa aacttcatca attgtatcca tccctattgc cagagtttta gtgataacct    360

ctcaaaaatc tagtctatta ttggagctta tatctcccct tctctctacc aattctgttc    420

ttccaagaat agctctctac ccttttaaaa tctaatacaa tttagccttg tcacttctcc    480

ggttgctcac tcaaacttta taccagtcat gtcaacacac atcctggtag ctgagcaagt    540

gtatacagaa acatttttag aagctaaa                                       568


<210>  3026
<211>  52
<212>  PRT
<213>  Homo sapiens

<400>  3026


Met Ile Asn Ser Lys Thr Ser Ser Ile Val Ser Ile Pro Ile Ala Arg 
1               5                   10                  15      


Val Leu Val Ile Thr Ser Gln Lys Ser Ser Leu Leu Leu Glu Leu Ile 
            20                  25                  30          


Ser Pro Leu Leu Ser Thr Asn Ser Val Leu Pro Arg Ile Ala Leu Tyr 
        35                  40                  45              


Pro Phe Lys Ile 
    50          

<210>  3027
<211>  368
<212>  DNA
<213>  Homo sapiens

<400>  3027
aggtctcacc aaaactgaaa aaatagaatc agagatacac gttgtacgtg gtgaaggttt     60

taagactgtt gcagcaacac gatatgaaac aataacagcc atgaccaacc tggccatagt    120

aaactgtcaa gtatatggga gaaatgcact taatctgaag atcacttgaa aaactgactg    180

ttgatgggaa tgaactgagt tttttccccc atggaatttt gaagcttaac ctgacaaaaa    240

ttcagtttga gaataatttc actcatcctt gtttttggag agataattat ttgaataatc    300

cacaacaact tactcaaatt atttctttgt tcattgtcca aaataaacta cataaatttt    360

atgataag                                                             368


<210>  3028
<211>  69
<212>  PRT
<213>  Homo sapiens

<400>  3028


Arg Ser Leu Glu Lys Leu Thr Val Asp Gly Asn Glu Leu Ser Phe Phe 
1               5                   10                  15      


Pro His Gly Ile Leu Lys Leu Asn Leu Thr Lys Ile Gln Phe Glu Asn 
            20                  25                  30          


Asn Phe Thr His Pro Cys Phe Trp Arg Asp Asn Tyr Leu Asn Asn Pro 
        35                  40                  45              


Gln Gln Leu Thr Gln Ile Ile Ser Leu Phe Ile Val Gln Asn Lys Leu 
    50                  55                  60                  


His Lys Phe Tyr Asp 
65                  

<210>  3029
<211>  532
<212>  DNA
<213>  Homo sapiens

<400>  3029
acaacagaga agctcagtaa gagtaaagga tgttggaaag aaaccaatag ggaatagatt     60

gaagatgtgg aaggatgaca gatgaagcag aatttcacag gagatgggag gggaagaagt    120

catcagctca ggtggagatt ctggtcttga acaggaggag taaccattat ctcctaaaac    180

tggagatgga ggaagggagc catgagtcaa ggaatgaggc agcttgaaaa cctgggaatg    240

gccttcagca tacagccaac aagaaaacaa gggcctcagt tctacagccg gaaagaactg    300

aattctgcca acagcctgca tgaatcactt gaaaaactga ctgttgatgg gaatgaactg    360

agttttttcc cccatggaat tttgaagctt aacctgacaa aaattcagtt tgagaataat    420

ttcactcatc cttgtttttg gagagataat tatttgaata atccacaaca acttactcaa    480

attatttctt tgttcattgt ccaaaataaa ctacataaat tttatgataa ga            532


<210>  3030
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  3030


Met Ser Gln Gly Met Arg Gln Leu Glu Asn Leu Gly Met Ala Phe Ser 
1               5                   10                  15      


Ile Gln Pro Thr Arg Lys Gln Gly Pro Gln Phe Tyr Ser Arg Lys Glu 
            20                  25                  30          


Leu Asn Ser Ala Asn Ser Leu His Glu Ser Leu Glu Lys Leu Thr Val 
        35                  40                  45              


Asp Gly Asn Glu Leu Ser Phe Phe Pro His Gly Ile Leu Lys Leu Asn 
    50                  55                  60                  


Leu Thr Lys Ile Gln Phe Glu Asn Asn Phe Thr His Pro Cys Phe Trp 
65                  70                  75                  80  


Arg Asp Asn Tyr Leu Asn Asn Pro Gln Gln Leu Thr Gln Ile Ile Ser 
                85                  90                  95      


Leu Phe Ile Val Gln Asn Lys Leu His Lys Phe Tyr Asp 
            100                 105                 

<210>  3031
<211>  415
<212>  DNA
<213>  Homo sapiens

<400>  3031
catgagtcaa ggaatgaggc agcttgaaaa cctgggaatg gccttcagca tacagccaac     60

aagaaaacaa gggcctcagt tctacagccg gaaagaactg aattctgcca acagcctgca    120

tgagttattt tccttgtctt atcttgaaga acttgatgtt tcctataatg aacttacttt    180

tattccaaat gaaattcaga aactcagatc acttgaaaaa ctgactgttg atgggaatga    240

actgagtttt ttcccccatg gaattttgaa gcttaacctg acaaaaattc agtttgagaa    300

taatttcact catccttgtt tttggagaga taattatttg aataatccac aacaacttac    360

tcaaattatt tctttgttca ttgtccaaaa taaactacat aaattttatg ataag         415


<210>  3032
<211>  137
<212>  PRT
<213>  Homo sapiens

<400>  3032


Met Ser Gln Gly Met Arg Gln Leu Glu Asn Leu Gly Met Ala Phe Ser 
1               5                   10                  15      


Ile Gln Pro Thr Arg Lys Gln Gly Pro Gln Phe Tyr Ser Arg Lys Glu 
            20                  25                  30          


Leu Asn Ser Ala Asn Ser Leu His Glu Leu Phe Ser Leu Ser Tyr Leu 
        35                  40                  45              


Glu Glu Leu Asp Val Ser Tyr Asn Glu Leu Thr Phe Ile Pro Asn Glu 
    50                  55                  60                  


Ile Gln Lys Leu Arg Ser Leu Glu Lys Leu Thr Val Asp Gly Asn Glu 
65                  70                  75                  80  


Leu Ser Phe Phe Pro His Gly Ile Leu Lys Leu Asn Leu Thr Lys Ile 
                85                  90                  95      


Gln Phe Glu Asn Asn Phe Thr His Pro Cys Phe Trp Arg Asp Asn Tyr 
            100                 105                 110         


Leu Asn Asn Pro Gln Gln Leu Thr Gln Ile Ile Ser Leu Phe Ile Val 
        115                 120                 125             


Gln Asn Lys Leu His Lys Phe Tyr Asp 
    130                 135         

<210>  3033
<211>  622
<212>  DNA
<213>  Homo sapiens

<400>  3033
ttgctgaata tgaatgaata ccaaggcagc tggtctcagt caaactgcag caacgctggg     60

catgcagctc aacatcctct gagactctgt cctcattttg cgaaattagg gacaaccaga    120

cctatcttcc tgtcctatca taagaattaa agaagacatg ggagtattcc gtatacagag    180

gaaagcagag ggagtcttga aacagcagaa gaggagacag caatgcaatc acagaagcag    240

agattggagc aatgtggcca cgccacaagg aatgcccaca gcaccagaag ctgaaagagg    300

caagaaatgg attctcccta agagcctctg gaaggaacac agccttcttg gtttgggccc    360

agtgaaactc actatagaac ctctggcctc cagaactgtg agagcataca tttctgttgg    420

tttaaatcag caagtttgtg gtaatttgtt acaccctagg tttacggtct aatacaccac    480

ctcagatgag gagaatgaga actccattat gggaaaggta aaatgaaaat ttagaagtgg    540

ctaagttgcc agataactct gaaaccataa cagctctgag cttccttcat cagacttttt    600

taaatgagaa agggataaac tt                                             622


<210>  3034
<211>  104
<212>  PRT
<213>  Homo sapiens

<400>  3034


Met Gly Val Phe Arg Ile Gln Arg Lys Ala Glu Gly Val Leu Lys Gln 
1               5                   10                  15      


Gln Lys Arg Arg Gln Gln Cys Asn His Arg Ser Arg Asp Trp Ser Asn 
            20                  25                  30          


Val Ala Thr Pro Gln Gly Met Pro Thr Ala Pro Glu Ala Glu Arg Gly 
        35                  40                  45              


Lys Lys Trp Ile Leu Pro Lys Ser Leu Trp Lys Glu His Ser Leu Leu 
    50                  55                  60                  


Gly Leu Gly Pro Val Lys Leu Thr Ile Glu Pro Leu Ala Ser Arg Thr 
65                  70                  75                  80  


Val Arg Ala Tyr Ile Ser Val Gly Leu Asn Gln Gln Val Cys Gly Asn 
                85                  90                  95      


Leu Leu His Pro Arg Phe Thr Val 
            100                 

<210>  3035
<211>  563
<212>  DNA
<213>  Homo sapiens

<400>  3035
gtgctcctct ggaagccctc tgactaccag ccgcttgtct cttcttccgc agttgagaaa     60

tagacggtcc acagcggaca acttagaatg gaataaggga gatgtgtttg aggcactacc    120

attggaagat gtgctgggga gaagcccagc ccagcaacat gcggcaggac cacatctcgg    180

cagagctgaa gacagagaca ttgcagcgac aaggacaact ggcatgcctc acattcctca    240

gtgttgaaaa caataaaagg agggggaatg agagaaaaat caaatttcta cgaagagatg    300

tcagcagtaa atttaatgca gctgccacaa acagagtgaa tgcagagcca tcaagagcca    360

agttctacaa gagataaatc agctgagact accactagac atctgcaagc agaagattag    420

gagagtaaat ttgcgagaca catatgcata tgacccagaa accaagttgc gtgaaactac    480

catggtttgt gcctcgatag gttgaacaag gacatggtga gaagacagcc atctgcaagc    540

cagaaagagc gctaaccaga acg                                            563


<210>  3036
<211>  91
<212>  PRT
<213>  Homo sapiens

<400>  3036


Met Cys Leu Arg His Tyr His Trp Lys Met Cys Trp Gly Glu Ala Gln 
1               5                   10                  15      


Pro Ser Asn Met Arg Gln Asp His Ile Ser Ala Glu Leu Lys Thr Glu 
            20                  25                  30          


Thr Leu Gln Arg Gln Gly Gln Leu Ala Cys Leu Thr Phe Leu Ser Val 
        35                  40                  45              


Glu Asn Asn Lys Arg Arg Gly Asn Glu Arg Lys Ile Lys Phe Leu Arg 
    50                  55                  60                  


Arg Asp Val Ser Ser Lys Phe Asn Ala Ala Ala Thr Asn Arg Val Asn 
65                  70                  75                  80  


Ala Glu Pro Ser Arg Ala Lys Phe Tyr Lys Arg 
                85                  90      

<210>  3037
<211>  588
<212>  DNA
<213>  Homo sapiens

<400>  3037
agaacatgtc ctcctcttct aaattacatg ccgtggagac acaaaggatt gccagctgaa     60

gcctgcatcc aggatcaacg atggatttgt gatggacgaa attgggagat tcttgcagcc    120

tgcttgaaat atctctgagc tatcttttcc atcaccatca gtccattaac cttcatctcc    180

aaactcttat agggtcagtc agaaagagac atatggaaag aaaaaaaaat gtgttaacat    240

gcaagacttg actgctgaat atccaaaggc aagcctgttg cactcttttt tgctaaggat    300

ccatacagtg catttgataa tctctcaact tggtggcagc catgtgaaga tgtgcctgct    360

tcccatttgc cttccaccat gattgtatgt ttccagaggc caccccagac atgcttcccg    420

tatagcctgt ggaaccatgc accaattaaa tctcttttct ttacaaatta cccagtctca    480

ggccctgaca tcatgatgat gatgataata cctgatattt acagagcacc tactatgtac    540

cagaaatgac tcattgtctt ctataagctt tagttgattt aatttccc                 588


<210>  3038
<211>  56
<212>  PRT
<213>  Homo sapiens

<400>  3038


Met Ile Val Cys Phe Gln Arg Pro Pro Gln Thr Cys Phe Pro Tyr Ser 
1               5                   10                  15      


Leu Trp Asn His Ala Pro Ile Lys Ser Leu Phe Phe Thr Asn Tyr Pro 
            20                  25                  30          


Val Ser Gly Pro Asp Ile Met Met Met Met Ile Ile Pro Asp Ile Tyr 
        35                  40                  45              


Arg Ala Pro Thr Met Tyr Gln Lys 
    50                  55      

<210>  3039
<211>  1658
<212>  DNA
<213>  Homo sapiens

<400>  3039
ccacagtact aagactgagg tacctgtcta catcaaaaga tgagtactac aatgcagatg     60

acttagccag ttggctgact agggatgttg gatgccaggt ctcctcagaa agatcaaagt    120

tacaggtgaa tgcccatgat ttaaatggaa atctgaggga atgaagcaag gacctgttgg    180

agcacccatg ggaagaacct ggggcacaaa agaggaaagc agcaagagac tgacagagat    240

tgtctcccta gaaacctgga ccacgaaaag ggtggagagg agaaaactct gtgctaaata    300

ttactcctgg aaaagtgcat ttgcttcgga gaaatcttta tcatgggtct ctaagaggaa    360

ggaacaatag catcttctat gtgccgaggt agcgcaataa tgaactctgt tcaagtggat    420

caaaagccat caaggtcaaa attaggcaca ggctgtacag gaagcgtgat tctggcatct    480

gtttggtttc tgggaaggcc tcaggaaact taaagtcatg gaagaagggg aagggagagc    540

aggcacgtct tacatgacca aagcaggaag aagagagaga agtgtggagg tgctatacac    600

ttttaaacag ccagatcttg tgagaactct gtcagaagaa cagcactagg gaaatggtgc    660

taaaccattc ttggggactc catccctgtg atacaatcac ctcccaccag gccccacctc    720

caacactgag aattacaact caacatgaga tttggatggg gacacagatc caaaccatat    780

caaattttca cacctttcag taaagcttta tattttttaa ggatatttaa gtacttggaa    840

gtagaagtag agagtaaggg gaatattgta cagccatcac agcctttgtc tactaaagaa    900

gtcagtttca tgtgacaaat gttcatttta atattcgctt cttcagtcca tctgggggtg    960

tttccttatt tctataagat gctgcttttc aaaaaaatta ccgaaagcat tctggaaatc   1020

caagagtaat tgtgtgaact ataagcatta gaaaacacag acataagttg aaaatattta   1080

tgaacctaaa tagatgtaaa gctagtgact catattttat aatgtattca cagatgatat   1140

ttcttaaata aagtaggcat ttctttaaaa taaaaactct aataatatat gttattaaga   1200

agaaaactag aaaaggaaga aaaaaagtga tggtatgttt ggaagatgct gaggtgagct   1260

ggtgataaaa ttatctccac tgaaaaagga atacaaagag cagacactga ataagccaga   1320

caatgtttga gttttttctg aaaccactgt gcagttttgg actttgacct gatttaattt   1380

tcacctctgt tcttcctccc actccttctc ttccttcatc tcatcctcct ctgcctttta   1440

cctcttttaa aaattgcatt ttgcaaacaa atacatgttt gccatcaatg aaactatttc   1500

aagagttcta tagagatcaa aatgaagggc ttcctgcgtt gatggttaat tctaccatct   1560

tccccaggtg caacagctgt tagcagtata gccttcagtt accagtttca ggcatttacc   1620

tatgcgtctg aacaaatgca ttaaaaaata atgaacac                           1658


<210>  3040
<211>  69
<212>  PRT
<213>  Homo sapiens

<400>  3040


Met Lys Gln Gly Pro Val Gly Ala Pro Met Gly Arg Thr Trp Gly Thr 
1               5                   10                  15      


Lys Glu Glu Ser Ser Lys Arg Leu Thr Glu Ile Val Ser Leu Glu Thr 
            20                  25                  30          


Trp Thr Thr Lys Arg Val Glu Arg Arg Lys Leu Cys Ala Lys Tyr Tyr 
        35                  40                  45              


Ser Trp Lys Ser Ala Phe Ala Ser Glu Lys Ser Leu Ser Trp Val Ser 
    50                  55                  60                  


Lys Arg Lys Glu Gln 
65                  

<210>  3041
<211>  2555
<212>  DNA
<213>  Homo sapiens

<400>  3041
gaaggtgcgt gcttcctttt cgcctcccac cataattact ctccactgag gggtttggca     60

ccagcacccc gcccagagca gtgccgctgc ccaaatcctc gcaggcagct catcaacgca    120

attgcaactc cggctggagc cccggacctg caagcctggg tgtccgtggg tccgtctgcc    180

cagccatctg ctggtggcac ctctccctcc tgccgcctcc ctcggtgaac cccaccttgc    240

agaagtgcag ctcgcccgga gcagcccagg agctcagcat gcgtccccca ggcttcagga    300

acttcttgct gctggcgtcc tcccttctct ttgctgggtt gtcagctgtt cctcaaagct    360

tctcgccatc tctgaggagc tggccgggcg ccgcctgcag gctgtcccgg gccgagtcgg    420

agcgacgctg ccgcgcacct gggcagcccc cgggggccgc gctgtgccac ggccggggcc    480

gctgcgactg cggcgtctgc atctgccacg tgactgagcc gggcatgttc ttcgggcccc    540

tgtgtgagtg ccatgagtgg gtgtgcgaga cctacgacgg gagcacctgt gcaggccatg    600

gtaagtgtga ctgtggcaag tgcaagtgtg accagggatg gtatggggat gcttgccagt    660

acccaactaa ctgtgacttg acaaagaaga aaagtaacca aatgtgcaag aattcacaag    720

acatcatctg ctctaatgca ggtacatgtc actgtggcag gtgtaagtgt gataattcag    780

atggaagtgg acttgtgtat ggtaaatttt gtgagtgtga cgatagagaa tgcatagacg    840

atgaaacaga agaaatatgt ggaggccatg ggaagtgtta ctgtggaaac tgctactgca    900

aggctggttg gcatggagat aaatgtgaat tccagtgcga tatcaccccc tgggaaagca    960

agcgaagatg cacgtctcca gatggcaaaa tctgcagtaa cagagggact tgtgtatgtg   1020

gtgaatgtac ctgtcacgat gttgatccga ctggggactg gggagatatt catggggaca   1080

cctgtgaatg tgatgagagg gactgtagag ctgtctatga ccgatattct gatgacttct   1140

gttcaggtca tggacagtgt aattgcggaa gatgtgactg caaagcaggc tggtatggga   1200

agaagtgtga gcacccacag tcctgcacgc tgtcagctga ggagagcatc aggaagtgcc   1260

agggaagctc ggatctgcct tgctctggga ggggtaaatg tgaatgtggc aaatgcacct   1320

gctatcctcc aggagatcgc cgggtgtatg gcaagacttg tgagtgtgat gatcgccgct   1380

gtgaagacct cgatggtgtg gtctgtggag gccacggcac atgttcctgt ggtcgctgtg   1440

tttgtgagag aggatggttt ggaaagctct gccaacatcc gcggaagtgt aacatgacgg   1500

aagaacaaag caagaatctg tgtgaatcag cagatggcat attgtgctcg gggaagggtt   1560

cttgtcattg tgggaagtgc atttgttctg ctgaagagtg gtatatttct ggggagttct   1620

gtgactgtga tgacagagac tgcgacaaac atgatggtct catttgtaca gggaatggaa   1680

tatgtagctg tggaaactgt gaatgctggg atggatggaa tggaaatgca tgtgaaatct   1740

ggcttggctc agaatatcct taacaattac atgagagagg tctggattct tattttttct   1800

gggccattag aacagataaa tgcgaaggaa accatgtata ttcaccacta ggacaggtta   1860

aaaagaccat tgtatgtttt tctatttctg aattacgaat gaaatccgag tacctattag   1920

aaatgagtta tgcaaattta gatgcaaata acattagaaa aaaaagattc ttccataatt   1980

aacataagtg gttcctaacg agagcaattt ttccacccaa aagtcatttg gcaacatcta   2040

cagacaattt tgattgtcac actgggtcgg gtaggaaggt atgctgcaga catttggtgg   2100

gtagaggcca gggatgctgc tgagcatccc gcagtgtaca ggacagcccc caaacaagga   2160

attatccagc cccaaatgcc aatagggctc aaactgagaa acattgagtt atatggctat   2220

tagaaatcca cattcttaca caagaaagac catattagaa tctaaggaaa acatgcatat   2280

tcacattaat taatcgatca gatttttcca gaattccgta tcagtcacca ttttaatatg   2340

gggacaatga agacaagcac acaggaggta gaatatcaga gtggggctgg atcaagggca   2400

aaaactggtc attaagtcat ctgacattaa atcatttagc cactaagtta tttgtctact   2460

ctcactttaa actcaccaaa gaagattctc ttaaagaaat tatgaaaaat gtacaattta   2520

acattttaaa taaatagtga cagaagttgt ttata                              2555


<210>  3042
<211>  494
<212>  PRT
<213>  Homo sapiens

<400>  3042


Met Arg Pro Pro Gly Phe Arg Asn Phe Leu Leu Leu Ala Ser Ser Leu 
1               5                   10                  15      


Leu Phe Ala Gly Leu Ser Ala Val Pro Gln Ser Phe Ser Pro Ser Leu 
            20                  25                  30          


Arg Ser Trp Pro Gly Ala Ala Cys Arg Leu Ser Arg Ala Glu Ser Glu 
        35                  40                  45              


Arg Arg Cys Arg Ala Pro Gly Gln Pro Pro Gly Ala Ala Leu Cys His 
    50                  55                  60                  


Gly Arg Gly Arg Cys Asp Cys Gly Val Cys Ile Cys His Val Thr Glu 
65                  70                  75                  80  


Pro Gly Met Phe Phe Gly Pro Leu Cys Glu Cys His Glu Trp Val Cys 
                85                  90                  95      


Glu Thr Tyr Asp Gly Ser Thr Cys Ala Gly His Gly Lys Cys Asp Cys 
            100                 105                 110         


Gly Lys Cys Lys Cys Asp Gln Gly Trp Tyr Gly Asp Ala Cys Gln Tyr 
        115                 120                 125             


Pro Thr Asn Cys Asp Leu Thr Lys Lys Lys Ser Asn Gln Met Cys Lys 
    130                 135                 140                 


Asn Ser Gln Asp Ile Ile Cys Ser Asn Ala Gly Thr Cys His Cys Gly 
145                 150                 155                 160 


Arg Cys Lys Cys Asp Asn Ser Asp Gly Ser Gly Leu Val Tyr Gly Lys 
                165                 170                 175     


Phe Cys Glu Cys Asp Asp Arg Glu Cys Ile Asp Asp Glu Thr Glu Glu 
            180                 185                 190         


Ile Cys Gly Gly His Gly Lys Cys Tyr Cys Gly Asn Cys Tyr Cys Lys 
        195                 200                 205             


Ala Gly Trp His Gly Asp Lys Cys Glu Phe Gln Cys Asp Ile Thr Pro 
    210                 215                 220                 


Trp Glu Ser Lys Arg Arg Cys Thr Ser Pro Asp Gly Lys Ile Cys Ser 
225                 230                 235                 240 


Asn Arg Gly Thr Cys Val Cys Gly Glu Cys Thr Cys His Asp Val Asp 
                245                 250                 255     


Pro Thr Gly Asp Trp Gly Asp Ile His Gly Asp Thr Cys Glu Cys Asp 
            260                 265                 270         


Glu Arg Asp Cys Arg Ala Val Tyr Asp Arg Tyr Ser Asp Asp Phe Cys 
        275                 280                 285             


Ser Gly His Gly Gln Cys Asn Cys Gly Arg Cys Asp Cys Lys Ala Gly 
    290                 295                 300                 


Trp Tyr Gly Lys Lys Cys Glu His Pro Gln Ser Cys Thr Leu Ser Ala 
305                 310                 315                 320 


Glu Glu Ser Ile Arg Lys Cys Gln Gly Ser Ser Asp Leu Pro Cys Ser 
                325                 330                 335     


Gly Arg Gly Lys Cys Glu Cys Gly Lys Cys Thr Cys Tyr Pro Pro Gly 
            340                 345                 350         


Asp Arg Arg Val Tyr Gly Lys Thr Cys Glu Cys Asp Asp Arg Arg Cys 
        355                 360                 365             


Glu Asp Leu Asp Gly Val Val Cys Gly Gly His Gly Thr Cys Ser Cys 
    370                 375                 380                 


Gly Arg Cys Val Cys Glu Arg Gly Trp Phe Gly Lys Leu Cys Gln His 
385                 390                 395                 400 


Pro Arg Lys Cys Asn Met Thr Glu Glu Gln Ser Lys Asn Leu Cys Glu 
                405                 410                 415     


Ser Ala Asp Gly Ile Leu Cys Ser Gly Lys Gly Ser Cys His Cys Gly 
            420                 425                 430         


Lys Cys Ile Cys Ser Ala Glu Glu Trp Tyr Ile Ser Gly Glu Phe Cys 
        435                 440                 445             


Asp Cys Asp Asp Arg Asp Cys Asp Lys His Asp Gly Leu Ile Cys Thr 
    450                 455                 460                 


Gly Asn Gly Ile Cys Ser Cys Gly Asn Cys Glu Cys Trp Asp Gly Trp 
465                 470                 475                 480 


Asn Gly Asn Ala Cys Glu Ile Trp Leu Gly Ser Glu Tyr Pro 
                485                 490                 

<210>  3043
<211>  1971
<212>  DNA
<213>  Homo sapiens

<400>  3043
agagcagtgc cgctgcccaa atcctcgcag gcagctcatc aacgcaattg caactccggc     60

tggagccccg gacctgcaag cctgggtgtc cgtgggtccg tctgcccagc catctgctgg    120

tggcacctct ccctcctgcc acgtgactga gccgggcatg ttcttcgggc ccctgtgtga    180

gtgccatgag tgggtgtgcg agacctacga cgggagcacc tgtgcaggcc atggtaagtg    240

tgactgtggc aagtgcaagt gtgaccaggg atggtatggg gatgcttgcc agtacccaac    300

taactgtgac ttgacaaaga agaaaagtaa ccaaatgtgc aagaattcac aagacatcat    360

ctgctctaat gcaggtacat gtcactgtgg caggtgtaag tgtgataatt cagatggaag    420

tggacttgtg tatggtaaat tttgtgagtg tgacgataga gaatgcatag acgatgaaac    480

agaagaaata tgtggaggcc atgggaagtg ttactgtgga aactgctact gcaaggctgg    540

ttggcatgga gataaatgtg aattccagtg cgatatcacc ccctgggaaa gcaagcgaag    600

atgcacgtct ccagatggca aaatctgcag taacagaggg acttgtgtat gtggtgaatg    660

tacctgtcac gatgttgatc cgactgggga ctggggagat attcatgggg acacctgtga    720

atgtgatgag agggactgta gagctgtcta tgaccgatat tctgatgact tctgttcagg    780

tcatggacag tgtaattgcg gaagatgtga ctgcaaagca ggctggtatg ggaagaagtg    840

tgagcaccca cagtcctgca cgctgtcagc tgaggagagc atcaggaagt gccagggaag    900

ctcggatctg ccttgctctg ggaggggtaa atgtgaatgt ggcaaatgca cctgctatcc    960

tccaggagat cgccgggtgt atggcaagac ttgtgagtgt gatgatcgcc gctgtgaaga   1020

cctcgatggt gtggtctgtg gaggccacgg cacatgttcc tgtggtcgct gtgtttgtga   1080

gagaggatgg tttggaaagc tctgccaaca tccgcggaag tgtaacatga cggaagaaca   1140

aagcaagaat ctgtgtgaat cagcagatgg catattgtgc tcggggaagg gttcttgtca   1200

ttgtgggaag tgcatttgtt ctgctgaaga gtggtatatt tctggggagt tctgtgactg   1260

tgatgacaga gactgcgaca aacatgatgg tctcatttgt acagggaatg gaatatgtag   1320

ctgtggaaac tgtgaatgct gggatggatg gaatggaaat gcatgtgaaa tctggcttgg   1380

ctcagaatat ccttaacaat tacatgagag aggtctggat tcttattttt tctgggccat   1440

tagaacagat aaatgcgaag gaaaccatgt atattcacca ctaggacagg ttaaaaagac   1500

cattgtatgt ttttctattt ctgaattacg aatgaaatcc gagtacctat tagaaatgag   1560

ttatgcaaat ttagatgcaa ataacattag aaaaaaaaga ttcttccata attaacataa   1620

ttgagttata tggctattag aaatccacat tcttacacaa gaaagaccat attagaatct   1680

aaggaaaaca tgcatattca cattaattaa tcgatcagat ttttccagaa ttccgtatca   1740

gtcaccattt taatatgggg acaatgaaga caagcacaca ggaggtagaa tatcagagtg   1800

gggctggatc aagggcaaaa actggtcatt aagtcatctg acattaaatc atttagccac   1860

taagttattt gtctactctc actttaaact caccaaagaa gattctctta aagaaattat   1920

gaaaaatgta caatttaaca ttttaaataa atagtgacag aagttgttta t            1971


<210>  3044
<211>  412
<212>  PRT
<213>  Homo sapiens

<400>  3044


Met Phe Phe Gly Pro Leu Cys Glu Cys His Glu Trp Val Cys Glu Thr 
1               5                   10                  15      


Tyr Asp Gly Ser Thr Cys Ala Gly His Gly Lys Cys Asp Cys Gly Lys 
            20                  25                  30          


Cys Lys Cys Asp Gln Gly Trp Tyr Gly Asp Ala Cys Gln Tyr Pro Thr 
        35                  40                  45              


Asn Cys Asp Leu Thr Lys Lys Lys Ser Asn Gln Met Cys Lys Asn Ser 
    50                  55                  60                  


Gln Asp Ile Ile Cys Ser Asn Ala Gly Thr Cys His Cys Gly Arg Cys 
65                  70                  75                  80  


Lys Cys Asp Asn Ser Asp Gly Ser Gly Leu Val Tyr Gly Lys Phe Cys 
                85                  90                  95      


Glu Cys Asp Asp Arg Glu Cys Ile Asp Asp Glu Thr Glu Glu Ile Cys 
            100                 105                 110         


Gly Gly His Gly Lys Cys Tyr Cys Gly Asn Cys Tyr Cys Lys Ala Gly 
        115                 120                 125             


Trp His Gly Asp Lys Cys Glu Phe Gln Cys Asp Ile Thr Pro Trp Glu 
    130                 135                 140                 


Ser Lys Arg Arg Cys Thr Ser Pro Asp Gly Lys Ile Cys Ser Asn Arg 
145                 150                 155                 160 


Gly Thr Cys Val Cys Gly Glu Cys Thr Cys His Asp Val Asp Pro Thr 
                165                 170                 175     


Gly Asp Trp Gly Asp Ile His Gly Asp Thr Cys Glu Cys Asp Glu Arg 
            180                 185                 190         


Asp Cys Arg Ala Val Tyr Asp Arg Tyr Ser Asp Asp Phe Cys Ser Gly 
        195                 200                 205             


His Gly Gln Cys Asn Cys Gly Arg Cys Asp Cys Lys Ala Gly Trp Tyr 
    210                 215                 220                 


Gly Lys Lys Cys Glu His Pro Gln Ser Cys Thr Leu Ser Ala Glu Glu 
225                 230                 235                 240 


Ser Ile Arg Lys Cys Gln Gly Ser Ser Asp Leu Pro Cys Ser Gly Arg 
                245                 250                 255     


Gly Lys Cys Glu Cys Gly Lys Cys Thr Cys Tyr Pro Pro Gly Asp Arg 
            260                 265                 270         


Arg Val Tyr Gly Lys Thr Cys Glu Cys Asp Asp Arg Arg Cys Glu Asp 
        275                 280                 285             


Leu Asp Gly Val Val Cys Gly Gly His Gly Thr Cys Ser Cys Gly Arg 
    290                 295                 300                 


Cys Val Cys Glu Arg Gly Trp Phe Gly Lys Leu Cys Gln His Pro Arg 
305                 310                 315                 320 


Lys Cys Asn Met Thr Glu Glu Gln Ser Lys Asn Leu Cys Glu Ser Ala 
                325                 330                 335     


Asp Gly Ile Leu Cys Ser Gly Lys Gly Ser Cys His Cys Gly Lys Cys 
            340                 345                 350         


Ile Cys Ser Ala Glu Glu Trp Tyr Ile Ser Gly Glu Phe Cys Asp Cys 
        355                 360                 365             


Asp Asp Arg Asp Cys Asp Lys His Asp Gly Leu Ile Cys Thr Gly Asn 
    370                 375                 380                 


Gly Ile Cys Ser Cys Gly Asn Cys Glu Cys Trp Asp Gly Trp Asn Gly 
385                 390                 395                 400 


Asn Ala Cys Glu Ile Trp Leu Gly Ser Glu Tyr Pro 
                405                 410         

<210>  3045
<211>  1211
<212>  DNA
<213>  Homo sapiens

<400>  3045
gggaaaacaa aacgacattg cttattcttt aagtaaagaa cttgacacct ttaaagccac     60

cttttcagga gcccactcag tggcttctgt ttctttttca tacaattata tttcattgac    120

tttgattgca ttcgacagga tatagctatg cctatctgtg aatgagcctg ggaatagagc    180

ttcgtatttg ggcacattat aaacctgaaa aaaaaaattt gtctctaaga aacaaggggg    240

tcattatatt gtataggcaa ctagcattct cattgctttt tctctcattc ggggaaatta    300

agtataatca ataccttgag gcatagtttg caggttctat gcaaaagcct tctctggggt    360

gagccaggta agcagccagg gagtgagaca gggaatatct gacttcagaa acagtctcca    420

gttttgctgg aggagcaata taatgctgtt ctctgcctaa tgaaagcagt taataatgat    480

taatgccaaa gagtgagtgc tcagagggag gaacagagct gctggacagt atccaccttt    540

gattgatgtg tttccattgg cttttaccct tcattgtttc tttgcatctg caatggcgtg    600

aactgcaagc accattttga ggacagtatg cttcttgttg tagtctctca catattccac    660

cactccactg agtttcccta agaataaaac tcttttacag taatgggtgt ttccttttga    720

gagccaccag gtgtaattat tttaccttgt tgtatttcag ttaaaaaaaa atcattctta    780

atgtgaaaaa gcctaaaaaa tatatgaaga ttgcaaatta cataaacgaa tggtcaaaga    840

accttaagaa ataacttacc caaaggttaa aaaaaagtaa ttaaaatgta tatataaaag    900

ttccattaat ttggaaatat gaaacttttt tacttataaa ttggaaggat gtttttagtg    960

acattcaggg ttgataagaa ttcaccgtgg agtaactggc cagtgtgaat aaagagcctt   1020

aaacatctat acccctttcc caagtagttt tattttacag agtctacctc agtaaatgct   1080

acaaaatgca aaggtttata tatatgtatt aatacaatct ttgaaattta atttctaata   1140

ttggaaaaaa gaaagcaacc taaaaatcta ataagagaat taaatggtta aatagaatgc   1200

tgaaccacac t                                                        1211


<210>  3046
<211>  54
<212>  PRT
<213>  Homo sapiens

<400>  3046


Met Ser Leu Gly Ile Glu Leu Arg Ile Trp Ala His Tyr Lys Pro Glu 
1               5                   10                  15      


Lys Lys Asn Leu Ser Leu Arg Asn Lys Gly Val Ile Ile Leu Tyr Arg 
            20                  25                  30          


Gln Leu Ala Phe Ser Leu Leu Phe Leu Ser Phe Gly Glu Ile Lys Tyr 
        35                  40                  45              


Asn Gln Tyr Leu Glu Ala 
    50                  

<210>  3047
<211>  575
<212>  DNA
<213>  Homo sapiens

<400>  3047
aagcgtctca cctgtagtca aagagggaca gcatcaaagc agacactgct tttggcagtg     60

aaatgagcaa agagtgcccc cacgggtaac ccttcatgtt ggtgaggaca tgggaaagca    120

ctgctacaaa tctctggaga acaatttcta tgaagtgtga agaatagagt ttttgacatt    180

gtacttgttc tcttcactct tcgggattct ataagagatg tccagcaagc agcagagctg    240

ggcttacgat gttgtaccaa gcatggaagg aagcactgca aagctgacat cagcacaaat    300

acctgtggaa actgcagggg gcaaggcaat gaggtgctac ttcaagtagg atgtgaccat    360

ttgacatatc cttgctgaca attgaacaaa atgctctaat acggcaaaga atgagccgta    420

tcttcaaaac caagcagcaa cttcgttctc attctgcaga agagtggttt acaaacaaat    480

ctccaaccac ttcaaattca ctcaaccttc aacctttgga gggcaaatgt gcttgcaaac    540

attgatttcc agaaaaggta actgtgtctc cagta                               575


<210>  3048
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  3048


Met Ser Arg Ile Phe Lys Thr Lys Gln Gln Leu Arg Ser His Ser Ala 
1               5                   10                  15      


Glu Glu Trp Phe Thr Asn Lys Ser Pro Thr Thr Ser Asn Ser Leu Asn 
            20                  25                  30          


Leu Gln Pro Leu Glu Gly Lys Cys Ala Cys Lys His 
        35                  40                  

<210>  3049
<211>  1481
<212>  DNA
<213>  Homo sapiens

<400>  3049
atgacggaga gccgttcctc ctccagctgg ggacagagaa ggaggctgga ggagcgccgg     60

cagattgcga ggctcttcct cacgccacgt ttctgtgact tgagtgccct gggagtttta    120

cgctgcctcg tctcatatcg gcgagggacc gtaagcacgg ggacgcgccg tcacgcctca    180

tcggggaccg taagcacggg gacgcgccgt cacccctcat cggggaccgt acgcacgggg    240

acgcgccgtc acgcctcagc ggggaccgta cgcacgggga cgcgccgtca cccctcagcg    300

gggaccgtac gcacggggac gcgccgtcac ccctcagcgg ggaccgtacg cacggggacg    360

cgccgtcacg cctcagcggg gaccgtaagc acggggacgc gccgtcacgc ctcggcgggg    420

accgtacgca cggggacgcg ccgtcacgcc tcagcgggga ccgtaagcac ggggacgcgc    480

cgtcacgcct cggcggggac cgtacacacg gggacgcgcc gtcacgcctc agtggggacc    540

gtacccacgg ggacgcgccg tcacgcctcg gcggggaccg tacccacggg gaagcgccgt    600

cacgcctcag tggggaccgt acccacgggg acgcgccgtc acgcctcggc ggggaccgta    660

cccacgggga cgcgccgtca cgcctcggcg gggaccgtac ccacggggac gcgccgtcac    720

gcctcagtgg ggaccgtacc cacggggacg cgccgtcacg cctcggcggg gaccgtaccc    780

acggggaagc gccgtcacgc ctcagtgggg accgtaccca cggggacgcg ccgtcacgcc    840

tcggcgggga ccgtacacac ggggacgcgc cgtcacgcct cggcggggac cgtacacacg    900

gggacgcgcc gtcacgcctc agtggggacc gtacccacgg ggacgcgccg tcacgcctca    960

gcggggaccg tacacacggg gacgcgccgt cacgcctcag cggggaccgt acccacgggg   1020

acgcgccgtc acccctcggc ggggaccgta cacacgggga cgcgctgtca cgcctcagtg   1080

gggaccgtac ccacggggac gcgccatcac acctcagcgg ggaccgtaca cacggggacg   1140

cgccgtcacc cctcggtggg gaccgtacac acggggacgc gccgtcaccc ctcagcgggg   1200

accgtacaca cggggacgcg ctgtcacgcc tcagcgggga ccgtacacac ggggacccac   1260

tgtcacgcct cagcagggac cgtaagcacg gggacgcgcc gtcacccctc agcggggact   1320

gtacacacgg ggacgcgccg tcacccctca gcggggaccg tacgcacggg gacccactgt   1380

cacgcctcag cggggaccgt aaacacgggg acgcgccgtc acccctcagc ggggaccacc   1440

agctgctttg cccatggatt ggaacgcatt gggtggagta a                       1481


<210>  3050
<211>  492
<212>  PRT
<213>  Homo sapiens

<400>  3050


Met Thr Glu Ser Arg Ser Ser Ser Ser Trp Gly Gln Arg Arg Arg Leu 
1               5                   10                  15      


Glu Glu Arg Arg Gln Ile Ala Arg Leu Phe Leu Thr Pro Arg Phe Cys 
            20                  25                  30          


Asp Leu Ser Ala Leu Gly Val Leu Arg Cys Leu Val Ser Tyr Arg Arg 
        35                  40                  45              


Gly Thr Val Ser Thr Gly Thr Arg Arg His Ala Ser Ser Gly Thr Val 
    50                  55                  60                  


Ser Thr Gly Thr Arg Arg His Pro Ser Ser Gly Thr Val Arg Thr Gly 
65                  70                  75                  80  


Thr Arg Arg His Ala Ser Ala Gly Thr Val Arg Thr Gly Thr Arg Arg 
                85                  90                  95      


His Pro Ser Ala Gly Thr Val Arg Thr Gly Thr Arg Arg His Pro Ser 
            100                 105                 110         


Ala Gly Thr Val Arg Thr Gly Thr Arg Arg His Ala Ser Ala Gly Thr 
        115                 120                 125             


Val Ser Thr Gly Thr Arg Arg His Ala Ser Ala Gly Thr Val Arg Thr 
    130                 135                 140                 


Gly Thr Arg Arg His Ala Ser Ala Gly Thr Val Ser Thr Gly Thr Arg 
145                 150                 155                 160 


Arg His Ala Ser Ala Gly Thr Val His Thr Gly Thr Arg Arg His Ala 
                165                 170                 175     


Ser Val Gly Thr Val Pro Thr Gly Thr Arg Arg His Ala Ser Ala Gly 
            180                 185                 190         


Thr Val Pro Thr Gly Lys Arg Arg His Ala Ser Val Gly Thr Val Pro 
        195                 200                 205             


Thr Gly Thr Arg Arg His Ala Ser Ala Gly Thr Val Pro Thr Gly Thr 
    210                 215                 220                 


Arg Arg His Ala Ser Ala Gly Thr Val Pro Thr Gly Thr Arg Arg His 
225                 230                 235                 240 


Ala Ser Val Gly Thr Val Pro Thr Gly Thr Arg Arg His Ala Ser Ala 
                245                 250                 255     


Gly Thr Val Pro Thr Gly Lys Arg Arg His Ala Ser Val Gly Thr Val 
            260                 265                 270         


Pro Thr Gly Thr Arg Arg His Ala Ser Ala Gly Thr Val His Thr Gly 
        275                 280                 285             


Thr Arg Arg His Ala Ser Ala Gly Thr Val His Thr Gly Thr Arg Arg 
    290                 295                 300                 


His Ala Ser Val Gly Thr Val Pro Thr Gly Thr Arg Arg His Ala Ser 
305                 310                 315                 320 


Ala Gly Thr Val His Thr Gly Thr Arg Arg His Ala Ser Ala Gly Thr 
                325                 330                 335     


Val Pro Thr Gly Thr Arg Arg His Pro Ser Ala Gly Thr Val His Thr 
            340                 345                 350         


Gly Thr Arg Cys His Ala Ser Val Gly Thr Val Pro Thr Gly Thr Arg 
        355                 360                 365             


His His Thr Ser Ala Gly Thr Val His Thr Gly Thr Arg Arg His Pro 
    370                 375                 380                 


Ser Val Gly Thr Val His Thr Gly Thr Arg Arg His Pro Ser Ala Gly 
385                 390                 395                 400 


Thr Val His Thr Gly Thr Arg Cys His Ala Ser Ala Gly Thr Val His 
                405                 410                 415     


Thr Gly Thr His Cys His Ala Ser Ala Gly Thr Val Ser Thr Gly Thr 
            420                 425                 430         


Arg Arg His Pro Ser Ala Gly Thr Val His Thr Gly Thr Arg Arg His 
        435                 440                 445             


Pro Ser Ala Gly Thr Val Arg Thr Gly Thr His Cys His Ala Ser Ala 
    450                 455                 460                 


Gly Thr Val Asn Thr Gly Thr Arg Arg His Pro Ser Ala Gly Thr Thr 
465                 470                 475                 480 


Ser Cys Phe Ala His Gly Leu Glu Arg Ile Gly Trp 
                485                 490         

<210>  3051
<211>  1755
<212>  DNA
<213>  Homo sapiens

<400>  3051
atgccggcat ctcaggctcc agcaccacct gctgcacagg agaggcttcg ggaggtccac     60

tcgggggatc agcaggagac ccagaatcca catccaggcc tgtctgaccc cacagtctgt    120

gattttaaac actgtcaatg gaaggtccac cctgaggagc gggacccact gtcacgcctc    180

agcagggacc gtacgcgagg ggacgccctg ttacgcctca gcggggaccg taagcacggg    240

gacacgccgt cacccctaag cggggaccga acacacaggg acccactgtc acccctcatc    300

ggggaccgta agcacaggga cgcgccgtca cgcctcatcg gggaccgtaa gcacggggac    360

gcgccgtcac gcctcatcgg ggaccgtaag cacggggacg cgccgtcacg cctcatcggg    420

gaccgtaagc acggggacgc gccgtcacgc ctcatcgggg accgtaagca cggggacgcg    480

ccgtcacccc tcatcgggga ccgtacgcac ggggacgcgc cgtcacgcct cagcggggac    540

cgtacgcacg gggacgcgcc gtcacccctc agcggggacc gtacgcacgg ggacgcgccg    600

tcacccctca gcggggaccg tacgcacggg gacgcgccgt cacgcctcag cggggaccgt    660

aagcacgggg acgcgccgtc acgcctcggc ggggaccgta cgcacgggga cgcgccgtca    720

cgcctcagcg gggaccgtaa gcacggggac gcgccgtcac gcctcggcgg ggaccgtaca    780

cacggggacg cgccgtcacg cctcagtggg gaccgtaccc acggggacgc gccgtcacgc    840

ctcggcgggg accgtaccca cggggaagcg ccgtcacgcc tcagtgggga ccgtacccac    900

ggggacgcgc cgtcacgcct cggcggggac cgtacccacg gggacgcgcc gtcacgcctc    960

ggcggggacc gtacccacgg ggacgcgccg tcacgcctca gtggggaccg tacccacggg   1020

gacgcgccgt cacgcctcgg cggggaccgt acccacgggg aagcgccgtc acgcctcagt   1080

ggggaccgta cccacgggga cgcgccgtca cgcctcggcg gggaccgtac acacggggac   1140

gcgccgtcac gcctcggcgg ggaccgtaca cacggggacg cgccgtcacg cctcagtggg   1200

gaccgtaccc acggggacgc gccgtcacgc ctcagcgggg accgtacaca cggggacgcg   1260

ccgtcacgcc tcagcgggga ccgtacccac ggggacgcgc cgtcacccct cggcggggac   1320

cgtacacacg gggacgcgct gtcacgcctc agtggggacc gtacccacgg ggacgcgcca   1380

tcacacctca gcggggaccg tacacacggg gacgcgccgt cacccctcgg tggggaccgt   1440

acacacgggg acgcgccgtc acccctcagc ggggaccgta cacacgggga cgcgctgtca   1500

cgcctcagcg gggaccgtac acacggggac ccactgtcac gcctcagcag ggaccgtaag   1560

cacggggacg cgccgtcacc cctcagcggg gactgtacac acggggacgc gccgtcaccc   1620

ctcagcgggg accgtacgca cggggaccca ctgtcacgcc tcagcgggga ccgtaaacac   1680

ggggacgcgc cgtcacccct cagcggggac caccagctgc tttgcccatg gattggaacg   1740

cattgggtgg agtaa                                                    1755


<210>  3052
<211>  584
<212>  PRT
<213>  Homo sapiens

<400>  3052


Met Pro Ala Ser Gln Ala Pro Ala Pro Pro Ala Ala Gln Glu Arg Leu 
1               5                   10                  15      


Arg Glu Val His Ser Gly Asp Gln Gln Glu Thr Gln Asn Pro His Pro 
            20                  25                  30          


Gly Leu Ser Asp Pro Thr Val Cys Asp Phe Lys His Cys Gln Trp Lys 
        35                  40                  45              


Val His Pro Glu Glu Arg Asp Pro Leu Ser Arg Leu Ser Arg Asp Arg 
    50                  55                  60                  


Thr Arg Gly Asp Ala Leu Leu Arg Leu Ser Gly Asp Arg Lys His Gly 
65                  70                  75                  80  


Asp Thr Pro Ser Pro Leu Ser Gly Asp Arg Thr His Arg Asp Pro Leu 
                85                  90                  95      


Ser Pro Leu Ile Gly Asp Arg Lys His Arg Asp Ala Pro Ser Arg Leu 
            100                 105                 110         


Ile Gly Asp Arg Lys His Gly Asp Ala Pro Ser Arg Leu Ile Gly Asp 
        115                 120                 125             


Arg Lys His Gly Asp Ala Pro Ser Arg Leu Ile Gly Asp Arg Lys His 
    130                 135                 140                 


Gly Asp Ala Pro Ser Arg Leu Ile Gly Asp Arg Lys His Gly Asp Ala 
145                 150                 155                 160 


Pro Ser Pro Leu Ile Gly Asp Arg Thr His Gly Asp Ala Pro Ser Arg 
                165                 170                 175     


Leu Ser Gly Asp Arg Thr His Gly Asp Ala Pro Ser Pro Leu Ser Gly 
            180                 185                 190         


Asp Arg Thr His Gly Asp Ala Pro Ser Pro Leu Ser Gly Asp Arg Thr 
        195                 200                 205             


His Gly Asp Ala Pro Ser Arg Leu Ser Gly Asp Arg Lys His Gly Asp 
    210                 215                 220                 


Ala Pro Ser Arg Leu Gly Gly Asp Arg Thr His Gly Asp Ala Pro Ser 
225                 230                 235                 240 


Arg Leu Ser Gly Asp Arg Lys His Gly Asp Ala Pro Ser Arg Leu Gly 
                245                 250                 255     


Gly Asp Arg Thr His Gly Asp Ala Pro Ser Arg Leu Ser Gly Asp Arg 
            260                 265                 270         


Thr His Gly Asp Ala Pro Ser Arg Leu Gly Gly Asp Arg Thr His Gly 
        275                 280                 285             


Glu Ala Pro Ser Arg Leu Ser Gly Asp Arg Thr His Gly Asp Ala Pro 
    290                 295                 300                 


Ser Arg Leu Gly Gly Asp Arg Thr His Gly Asp Ala Pro Ser Arg Leu 
305                 310                 315                 320 


Gly Gly Asp Arg Thr His Gly Asp Ala Pro Ser Arg Leu Ser Gly Asp 
                325                 330                 335     


Arg Thr His Gly Asp Ala Pro Ser Arg Leu Gly Gly Asp Arg Thr His 
            340                 345                 350         


Gly Glu Ala Pro Ser Arg Leu Ser Gly Asp Arg Thr His Gly Asp Ala 
        355                 360                 365             


Pro Ser Arg Leu Gly Gly Asp Arg Thr His Gly Asp Ala Pro Ser Arg 
    370                 375                 380                 


Leu Gly Gly Asp Arg Thr His Gly Asp Ala Pro Ser Arg Leu Ser Gly 
385                 390                 395                 400 


Asp Arg Thr His Gly Asp Ala Pro Ser Arg Leu Ser Gly Asp Arg Thr 
                405                 410                 415     


His Gly Asp Ala Pro Ser Arg Leu Ser Gly Asp Arg Thr His Gly Asp 
            420                 425                 430         


Ala Pro Ser Pro Leu Gly Gly Asp Arg Thr His Gly Asp Ala Leu Ser 
        435                 440                 445             


Arg Leu Ser Gly Asp Arg Thr His Gly Asp Ala Pro Ser His Leu Ser 
    450                 455                 460                 


Gly Asp Arg Thr His Gly Asp Ala Pro Ser Pro Leu Gly Gly Asp Arg 
465                 470                 475                 480 


Thr His Gly Asp Ala Pro Ser Pro Leu Ser Gly Asp Arg Thr His Gly 
                485                 490                 495     


Asp Ala Leu Ser Arg Leu Ser Gly Asp Arg Thr His Gly Asp Pro Leu 
            500                 505                 510         


Ser Arg Leu Ser Arg Asp Arg Lys His Gly Asp Ala Pro Ser Pro Leu 
        515                 520                 525             


Ser Gly Asp Cys Thr His Gly Asp Ala Pro Ser Pro Leu Ser Gly Asp 
    530                 535                 540                 


Arg Thr His Gly Asp Pro Leu Ser Arg Leu Ser Gly Asp Arg Lys His 
545                 550                 555                 560 


Gly Asp Ala Pro Ser Pro Leu Ser Gly Asp His Gln Leu Leu Cys Pro 
                565                 570                 575     


Trp Ile Gly Thr His Trp Val Glu 
            580                 

<210>  3053
<211>  973
<212>  DNA
<213>  Homo sapiens

<400>  3053
gagcctgggc agtgcacggg gcctgggtgg ggggtgcggg tgtgggtggg gacctgcggc     60

cttcgagtcc gcggccttcg agtcctgggg cggcggcggc ggctgcaggc acgggcacgg    120

gcacggggcg gggtgcttag ggtgcaggag gcgcgcgcct agcggcggag tgtggcgtga    180

ggccgggccc gcgccgccat gaacctagag cggctgcgga agcgcgtccg gcagtacctc    240

gaccagcaac agtatcaaag tgctctattt tgggcagata aagtagcttc actctctcgt    300

gaagaacccc aggacatcta ttggttggct cagtgtcttt acctgacagc acaatatcac    360

agagccgccc atgcacttcg gtcacgaaaa ctggacaaat tgtatgaagc atgtcgttac    420

cttgcagcta ggtgccatta tgctgcaaaa gagcaccagc aggcccttga tgttcttgac    480

atggaagagc ccatcaataa aagattattt gaaaaatact tgaaggacga aagtggcttc    540

aaagatcctt ccagcgactg ggaaatgtca cagtcttcaa taaagagttc tatctgtctt    600

ctacgcggga aaatctatga tgctctagat aaccgaaccc tggctaccta cagctacaaa    660

gaagctttga agcttgatgt ctactgtttt gaagcgttcg atcttttaac atcacatcac    720

atgctgacag cacaagaaga aaaagaactt cttgaatcac taccccttag caagctgtgt    780

aatgaagaac aggaattgct gcgttttcta tttgagaaca aattgaaaaa atataataag    840

cctagtgaaa cggtcatccc tgaatctgta gatggcttgc aagagaatct ggatgtggta    900

gtgtctttag ctgagagaca ttattataac tgtgatttta aaatgtgcta caagcttact    960

tctgtgtaag tat                                                       973


<210>  3054
<211>  256
<212>  PRT
<213>  Homo sapiens

<400>  3054


Met Asn Leu Glu Arg Leu Arg Lys Arg Val Arg Gln Tyr Leu Asp Gln 
1               5                   10                  15      


Gln Gln Tyr Gln Ser Ala Leu Phe Trp Ala Asp Lys Val Ala Ser Leu 
            20                  25                  30          


Ser Arg Glu Glu Pro Gln Asp Ile Tyr Trp Leu Ala Gln Cys Leu Tyr 
        35                  40                  45              


Leu Thr Ala Gln Tyr His Arg Ala Ala His Ala Leu Arg Ser Arg Lys 
    50                  55                  60                  


Leu Asp Lys Leu Tyr Glu Ala Cys Arg Tyr Leu Ala Ala Arg Cys His 
65                  70                  75                  80  


Tyr Ala Ala Lys Glu His Gln Gln Ala Leu Asp Val Leu Asp Met Glu 
                85                  90                  95      


Glu Pro Ile Asn Lys Arg Leu Phe Glu Lys Tyr Leu Lys Asp Glu Ser 
            100                 105                 110         


Gly Phe Lys Asp Pro Ser Ser Asp Trp Glu Met Ser Gln Ser Ser Ile 
        115                 120                 125             


Lys Ser Ser Ile Cys Leu Leu Arg Gly Lys Ile Tyr Asp Ala Leu Asp 
    130                 135                 140                 


Asn Arg Thr Leu Ala Thr Tyr Ser Tyr Lys Glu Ala Leu Lys Leu Asp 
145                 150                 155                 160 


Val Tyr Cys Phe Glu Ala Phe Asp Leu Leu Thr Ser His His Met Leu 
                165                 170                 175     


Thr Ala Gln Glu Glu Lys Glu Leu Leu Glu Ser Leu Pro Leu Ser Lys 
            180                 185                 190         


Leu Cys Asn Glu Glu Gln Glu Leu Leu Arg Phe Leu Phe Glu Asn Lys 
        195                 200                 205             


Leu Lys Lys Tyr Asn Lys Pro Ser Glu Thr Val Ile Pro Glu Ser Val 
    210                 215                 220                 


Asp Gly Leu Gln Glu Asn Leu Asp Val Val Val Ser Leu Ala Glu Arg 
225                 230                 235                 240 


His Tyr Tyr Asn Cys Asp Phe Lys Met Cys Tyr Lys Leu Thr Ser Val 
                245                 250                 255     

<210>  3055
<211>  2289
<212>  DNA
<213>  Homo sapiens

<400>  3055
ctgggcagtg cacggggcct gggtgggggg tgcgggtgtg ggtggggacc tgcggccttc     60

gagtccgcgg ccttcgagtc ctggggcggc ggcggcggct gcaggcacgg gcacgggcac    120

ggggcggggt gcttagggtg caggaggcgc gcgcctagcg gcggagtgtg gcgtgaggcc    180

gggcccgcgc cgccatgaac ctagagcggc tgcggaagcg cgtccggcag tacctcgacc    240

agcaacagta tcaaagtgct ctattttggg cagataaagt agcttcactc tctcgtgaag    300

aaccccagga catctattgg ttggctcagt gtctttacct gacagcacaa tatcacagag    360

ccgcccatgc acttcggtca cgaaaactgg acaaattgta tgaagcatgt cgttaccttg    420

cagctaggtg ccattatgct gcaaaagagc accagcaggc ccttgatgtt cttgacatgg    480

aagagcccat caataaaaga ttatttgaaa aatacttgaa ggacgaaagt ggcttcaaag    540

atccttccag cgactgggaa atgtcacagt cttcaataaa gagttctatc tgtcttctac    600

gcgggaaaat ctatgatgct ctagataacc gaaccctggc tacctacagc tacaaagaag    660

ctttgaagct tgatgtctac tgttttgaag cgttcgatct tttaacatca catcacatgc    720

tgacagcaca agaagaaaaa gaacttcttg aatcactacc ccttagcaag ctgtgtaatg    780

aagaacagga attgctgcgt tttctatttg agaacaaatt gaaaaaatat aataagccta    840

gtgaaacggt catccctgaa tctgtagatg gcttgcaaga gaatctggat gtggtagtgt    900

ctttagctga gagacattat tataactgtg attttaaaat gtgctacaag cttacttctg    960

tagtaatgga gaaagatcct ttccatgcaa gttgtttacc tgtacatata gggacgcttg   1020

tagagctgaa taaagccaat gaacttttct atctttctca taaactggtg gatttatatc   1080

ctagtaatcc tgtgtcttgg tttgcagtgg gatgttacta tctcatggtc ggtcataaaa   1140

atgaacatgc cagaagatat ctcagcaaag ccacaacact tgagaaaacc tatggacctg   1200

catggatagc ctatggacat tcatttgcgg tggagagtga gcacgaccaa gcgatggctg   1260

cttacttcac agcagcacag ctgatgaaag ggtgtcattt gcctatgctg tatattggat   1320

tagaatatgg tttgaccaat aactcaaaac tagctgaaag gttcttcagc caagctctga   1380

gcattgcacc ggaagaccct tttgttatgc atgaggtcgg cgtggttgca tttcagaatg   1440

gagaatggaa aacagccgaa aaatggtttc ttgatgcttt ggaaaaaatt aaagcaattg   1500

ggaacgaggt aacagttgac aaatgggaac ctttgttgaa caacttgggg catgtctgca   1560

gaaaacttaa aaagtatgct gaggccttgg attaccaccg tcaggcactg gtgttgattc   1620

ctcagaacgc atccacctac tctgctattg gatatatcca cagtctgatg ggcaactttg   1680

aaaatgctgt ggactacttc cacacagccc ttggtcttag gcgagatgat acattttctg   1740

ttacaatgct tggtcattgc atcgaaatgt acattggtga ttctgaagct tatattggag   1800

cagacattaa agacaaatta aaatgttatg actttgatgt gcatacaatg aagacactaa   1860

aaaacattat ttcacctccg tgggatttca gggaatttga agtagaaaaa cagactgcag   1920

aagaaacggg gcttacgcca ttggaaacct caaggaaaac tccagattcc agaccttcct   1980

tggaagaaac ctttgaaatt gaaatgaatg aaagtgacat gatgttagag acatctatgt   2040

cagaccacag cacgtgactc cagtcagtgg tcctggtccc actgtcccag tgtaggttag   2100

tattccttca catcctctcc atggcttaag aatgtcccac ttcctaacgt gactccaaac   2160

tgcatctcta catttaggaa cagagacccg ccttaagaga ctggatcgca cacctttgca   2220

acagatgtgt tctgattctc tgaacctaca aaatagttat acatagtgga ataaagaagg   2280

taaaccatc                                                           2289


<210>  3056
<211>  620
<212>  PRT
<213>  Homo sapiens

<400>  3056


Met Asn Leu Glu Arg Leu Arg Lys Arg Val Arg Gln Tyr Leu Asp Gln 
1               5                   10                  15      


Gln Gln Tyr Gln Ser Ala Leu Phe Trp Ala Asp Lys Val Ala Ser Leu 
            20                  25                  30          


Ser Arg Glu Glu Pro Gln Asp Ile Tyr Trp Leu Ala Gln Cys Leu Tyr 
        35                  40                  45              


Leu Thr Ala Gln Tyr His Arg Ala Ala His Ala Leu Arg Ser Arg Lys 
    50                  55                  60                  


Leu Asp Lys Leu Tyr Glu Ala Cys Arg Tyr Leu Ala Ala Arg Cys His 
65                  70                  75                  80  


Tyr Ala Ala Lys Glu His Gln Gln Ala Leu Asp Val Leu Asp Met Glu 
                85                  90                  95      


Glu Pro Ile Asn Lys Arg Leu Phe Glu Lys Tyr Leu Lys Asp Glu Ser 
            100                 105                 110         


Gly Phe Lys Asp Pro Ser Ser Asp Trp Glu Met Ser Gln Ser Ser Ile 
        115                 120                 125             


Lys Ser Ser Ile Cys Leu Leu Arg Gly Lys Ile Tyr Asp Ala Leu Asp 
    130                 135                 140                 


Asn Arg Thr Leu Ala Thr Tyr Ser Tyr Lys Glu Ala Leu Lys Leu Asp 
145                 150                 155                 160 


Val Tyr Cys Phe Glu Ala Phe Asp Leu Leu Thr Ser His His Met Leu 
                165                 170                 175     


Thr Ala Gln Glu Glu Lys Glu Leu Leu Glu Ser Leu Pro Leu Ser Lys 
            180                 185                 190         


Leu Cys Asn Glu Glu Gln Glu Leu Leu Arg Phe Leu Phe Glu Asn Lys 
        195                 200                 205             


Leu Lys Lys Tyr Asn Lys Pro Ser Glu Thr Val Ile Pro Glu Ser Val 
    210                 215                 220                 


Asp Gly Leu Gln Glu Asn Leu Asp Val Val Val Ser Leu Ala Glu Arg 
225                 230                 235                 240 


His Tyr Tyr Asn Cys Asp Phe Lys Met Cys Tyr Lys Leu Thr Ser Val 
                245                 250                 255     


Val Met Glu Lys Asp Pro Phe His Ala Ser Cys Leu Pro Val His Ile 
            260                 265                 270         


Gly Thr Leu Val Glu Leu Asn Lys Ala Asn Glu Leu Phe Tyr Leu Ser 
        275                 280                 285             


His Lys Leu Val Asp Leu Tyr Pro Ser Asn Pro Val Ser Trp Phe Ala 
    290                 295                 300                 


Val Gly Cys Tyr Tyr Leu Met Val Gly His Lys Asn Glu His Ala Arg 
305                 310                 315                 320 


Arg Tyr Leu Ser Lys Ala Thr Thr Leu Glu Lys Thr Tyr Gly Pro Ala 
                325                 330                 335     


Trp Ile Ala Tyr Gly His Ser Phe Ala Val Glu Ser Glu His Asp Gln 
            340                 345                 350         


Ala Met Ala Ala Tyr Phe Thr Ala Ala Gln Leu Met Lys Gly Cys His 
        355                 360                 365             


Leu Pro Met Leu Tyr Ile Gly Leu Glu Tyr Gly Leu Thr Asn Asn Ser 
    370                 375                 380                 


Lys Leu Ala Glu Arg Phe Phe Ser Gln Ala Leu Ser Ile Ala Pro Glu 
385                 390                 395                 400 


Asp Pro Phe Val Met His Glu Val Gly Val Val Ala Phe Gln Asn Gly 
                405                 410                 415     


Glu Trp Lys Thr Ala Glu Lys Trp Phe Leu Asp Ala Leu Glu Lys Ile 
            420                 425                 430         


Lys Ala Ile Gly Asn Glu Val Thr Val Asp Lys Trp Glu Pro Leu Leu 
        435                 440                 445             


Asn Asn Leu Gly His Val Cys Arg Lys Leu Lys Lys Tyr Ala Glu Ala 
    450                 455                 460                 


Leu Asp Tyr His Arg Gln Ala Leu Val Leu Ile Pro Gln Asn Ala Ser 
465                 470                 475                 480 


Thr Tyr Ser Ala Ile Gly Tyr Ile His Ser Leu Met Gly Asn Phe Glu 
                485                 490                 495     


Asn Ala Val Asp Tyr Phe His Thr Ala Leu Gly Leu Arg Arg Asp Asp 
            500                 505                 510         


Thr Phe Ser Val Thr Met Leu Gly His Cys Ile Glu Met Tyr Ile Gly 
        515                 520                 525             


Asp Ser Glu Ala Tyr Ile Gly Ala Asp Ile Lys Asp Lys Leu Lys Cys 
    530                 535                 540                 


Tyr Asp Phe Asp Val His Thr Met Lys Thr Leu Lys Asn Ile Ile Ser 
545                 550                 555                 560 


Pro Pro Trp Asp Phe Arg Glu Phe Glu Val Glu Lys Gln Thr Ala Glu 
                565                 570                 575     


Glu Thr Gly Leu Thr Pro Leu Glu Thr Ser Arg Lys Thr Pro Asp Ser 
            580                 585                 590         


Arg Pro Ser Leu Glu Glu Thr Phe Glu Ile Glu Met Asn Glu Ser Asp 
        595                 600                 605             


Met Met Leu Glu Thr Ser Met Ser Asp His Ser Thr 
    610                 615                 620 

<210>  3057
<211>  2207
<212>  DNA
<213>  Homo sapiens

<400>  3057
ctgggcagtg cacggggcct gggtgggggg tgcgggtgtg ggtggggacc tgcggccttc     60

gagtccgcgg ccttcgagtc ctggggcggc ggcggcggct gcaggcacgg gcacgggcac    120

ggggcggggt gcttagggtg caggaggcgc gcgcctagcg gcggagtgtg gcgtgaggcc    180

gggcccgcgc cgccatgaac ctagagcggc tgcggaagcg cgtccggcag tacctcgacc    240

agcaacagta tcaaagtgct ctattttggg cagataaagt agcttcactc tctcgtgaag    300

aaccccagga catctattgg ttggctcagt gtctttacct gacagcacaa tatcacagag    360

ccgcccatgc acttcggtca cgaaaactgg acaaattgta tgaagcatgt cgttaccttg    420

cagctaggtg ccattatgct gcaaaagagc accagcaggc ccttgatgtt cttgacatgg    480

aagagcccat caataaaaga ttatttgaaa aatacttgaa ggacgaaagt ggcttcaaag    540

atccttccag cgactgggaa atgtcacagt cttcaataaa gagttctatc tgtcttctac    600

gcgggaaaat ctatgatgct ctagataacc gaaccctggc tacctacagc tacaaagaag    660

ctttgaagct tgatgtctac tgttttgaag cgttcgatct tttaacatca catcacatgc    720

tgacagcaca agaagaaaaa gaacttcttg aatcactacc ccttagcaag ctgtgtaatg    780

aagaacagga attgctgcgt tttctatttg agaacaaatt gaaaaaatat aataagccta    840

gtgaaacggt catccctgaa tctgtagatg gcttgcaaga gaatctggat gtggtagtgt    900

ctttagctga gagacattat tataactgtg attttaaaat gtgctacaag cttacttctg    960

tagtaatgga gaaagatcct ttccatgcaa gttgtttacc tgtacatata gggacgcttg   1020

tagagctgaa taaagccaat gaacttttct atctttctca taaactggtg gatttatatc   1080

ctagtaatcc tgtgtcttgg tttgcagtgg gatgttacta tctcatggtc ggtcataaaa   1140

atgaacatgc cagaagatat ctcagcaaag ccacaacact tgagaaaacc tatggacctg   1200

catggatagc ctatggacat tcatttgcgg tggagagtga gcacgaccaa gcgatggctg   1260

cttacttcac agcagcacag ctgatgaaag ggtgtcattt gcctatgctg tatattggat   1320

tagaatatgg tttgaccaat aactcaaaac tagctgaaag gttcttcagc caagctctga   1380

gcattgcacc ggaagaccct tttgttatgc atgaggtcgg cgtggttgca tttcagaatg   1440

gagaatggaa aacagccgaa aaatggtttc ttgatgcttt ggaaaaaatt aaagcaattg   1500

ggaacgaggt aacagttgac aaatgggaac ctttgttgaa caacttgggg catgtctgca   1560

gaaaacttaa aaagtatgct gaggccttgg attaccaccg tcaggcactg gtgttgattc   1620

ctcagaacgc atccacctac tctgctattg gatatatcca cagtctgatg ggcaactttg   1680

aaaatgctgt ggactacttc cacacagccc ttggtcttag gcgagatgat acattttctg   1740

ttacaatgct tggtcattgc atcgaaatgt acattggtga ttctgaagct tatattggag   1800

cagacattaa agacaaatta aaatgttatg actttgatgt gcatacaatg aagacactaa   1860

aaaacattat ttcacctccg tgggatttca gggaatttga agtagaaaaa cagactgcag   1920

aagaaacggg gcttacgcca ttggaaacct caaggaaaac tccagattcc agaccttcct   1980

tggaagaaac ctttgaaatt gaaatgaatg aaagtgacat gatgttagag acatctatgt   2040

cagaccacag cacgtgactc cagtcagtgg tcctggtccc actgtcccag tgtaggaaca   2100

gagacccgcc ttaagagact ggatcgcaca cctttgcaac agatgtgttc tgattctctg   2160

aacctacaaa atagttatac atagtggaat aaagaaggta aaccatc                 2207


<210>  3058
<211>  620
<212>  PRT
<213>  Homo sapiens

<400>  3058


Met Asn Leu Glu Arg Leu Arg Lys Arg Val Arg Gln Tyr Leu Asp Gln 
1               5                   10                  15      


Gln Gln Tyr Gln Ser Ala Leu Phe Trp Ala Asp Lys Val Ala Ser Leu 
            20                  25                  30          


Ser Arg Glu Glu Pro Gln Asp Ile Tyr Trp Leu Ala Gln Cys Leu Tyr 
        35                  40                  45              


Leu Thr Ala Gln Tyr His Arg Ala Ala His Ala Leu Arg Ser Arg Lys 
    50                  55                  60                  


Leu Asp Lys Leu Tyr Glu Ala Cys Arg Tyr Leu Ala Ala Arg Cys His 
65                  70                  75                  80  


Tyr Ala Ala Lys Glu His Gln Gln Ala Leu Asp Val Leu Asp Met Glu 
                85                  90                  95      


Glu Pro Ile Asn Lys Arg Leu Phe Glu Lys Tyr Leu Lys Asp Glu Ser 
            100                 105                 110         


Gly Phe Lys Asp Pro Ser Ser Asp Trp Glu Met Ser Gln Ser Ser Ile 
        115                 120                 125             


Lys Ser Ser Ile Cys Leu Leu Arg Gly Lys Ile Tyr Asp Ala Leu Asp 
    130                 135                 140                 


Asn Arg Thr Leu Ala Thr Tyr Ser Tyr Lys Glu Ala Leu Lys Leu Asp 
145                 150                 155                 160 


Val Tyr Cys Phe Glu Ala Phe Asp Leu Leu Thr Ser His His Met Leu 
                165                 170                 175     


Thr Ala Gln Glu Glu Lys Glu Leu Leu Glu Ser Leu Pro Leu Ser Lys 
            180                 185                 190         


Leu Cys Asn Glu Glu Gln Glu Leu Leu Arg Phe Leu Phe Glu Asn Lys 
        195                 200                 205             


Leu Lys Lys Tyr Asn Lys Pro Ser Glu Thr Val Ile Pro Glu Ser Val 
    210                 215                 220                 


Asp Gly Leu Gln Glu Asn Leu Asp Val Val Val Ser Leu Ala Glu Arg 
225                 230                 235                 240 


His Tyr Tyr Asn Cys Asp Phe Lys Met Cys Tyr Lys Leu Thr Ser Val 
                245                 250                 255     


Val Met Glu Lys Asp Pro Phe His Ala Ser Cys Leu Pro Val His Ile 
            260                 265                 270         


Gly Thr Leu Val Glu Leu Asn Lys Ala Asn Glu Leu Phe Tyr Leu Ser 
        275                 280                 285             


His Lys Leu Val Asp Leu Tyr Pro Ser Asn Pro Val Ser Trp Phe Ala 
    290                 295                 300                 


Val Gly Cys Tyr Tyr Leu Met Val Gly His Lys Asn Glu His Ala Arg 
305                 310                 315                 320 


Arg Tyr Leu Ser Lys Ala Thr Thr Leu Glu Lys Thr Tyr Gly Pro Ala 
                325                 330                 335     


Trp Ile Ala Tyr Gly His Ser Phe Ala Val Glu Ser Glu His Asp Gln 
            340                 345                 350         


Ala Met Ala Ala Tyr Phe Thr Ala Ala Gln Leu Met Lys Gly Cys His 
        355                 360                 365             


Leu Pro Met Leu Tyr Ile Gly Leu Glu Tyr Gly Leu Thr Asn Asn Ser 
    370                 375                 380                 


Lys Leu Ala Glu Arg Phe Phe Ser Gln Ala Leu Ser Ile Ala Pro Glu 
385                 390                 395                 400 


Asp Pro Phe Val Met His Glu Val Gly Val Val Ala Phe Gln Asn Gly 
                405                 410                 415     


Glu Trp Lys Thr Ala Glu Lys Trp Phe Leu Asp Ala Leu Glu Lys Ile 
            420                 425                 430         


Lys Ala Ile Gly Asn Glu Val Thr Val Asp Lys Trp Glu Pro Leu Leu 
        435                 440                 445             


Asn Asn Leu Gly His Val Cys Arg Lys Leu Lys Lys Tyr Ala Glu Ala 
    450                 455                 460                 


Leu Asp Tyr His Arg Gln Ala Leu Val Leu Ile Pro Gln Asn Ala Ser 
465                 470                 475                 480 


Thr Tyr Ser Ala Ile Gly Tyr Ile His Ser Leu Met Gly Asn Phe Glu 
                485                 490                 495     


Asn Ala Val Asp Tyr Phe His Thr Ala Leu Gly Leu Arg Arg Asp Asp 
            500                 505                 510         


Thr Phe Ser Val Thr Met Leu Gly His Cys Ile Glu Met Tyr Ile Gly 
        515                 520                 525             


Asp Ser Glu Ala Tyr Ile Gly Ala Asp Ile Lys Asp Lys Leu Lys Cys 
    530                 535                 540                 


Tyr Asp Phe Asp Val His Thr Met Lys Thr Leu Lys Asn Ile Ile Ser 
545                 550                 555                 560 


Pro Pro Trp Asp Phe Arg Glu Phe Glu Val Glu Lys Gln Thr Ala Glu 
                565                 570                 575     


Glu Thr Gly Leu Thr Pro Leu Glu Thr Ser Arg Lys Thr Pro Asp Ser 
            580                 585                 590         


Arg Pro Ser Leu Glu Glu Thr Phe Glu Ile Glu Met Asn Glu Ser Asp 
        595                 600                 605             


Met Met Leu Glu Thr Ser Met Ser Asp His Ser Thr 
    610                 615                 620 

<210>  3059
<211>  2136
<212>  DNA
<213>  Homo sapiens

<400>  3059
ctgggcagtg cacggggcct gggtgggggg tgcgggtgtg ggtggggacc tgcggccttc     60

gagtccgcgg ccttcgagtc ctggggcggc ggcggcggct gcaggcacgg gcacgggcac    120

ggggcggggt gcttagggtg caggaggcgc gcgcctagcg gcggagtgtg gcgtgaggcc    180

gggcccgcgc cgccatgaac ctagagcggc tgcggaagcg cgtccggcag tacctcgacc    240

agcaacagta tcaaagtgct ctattttggg cagataaagt agcttcactc tctcgtgaag    300

aaccccagga catctattgg ttggctcagt gtctttacct gacagcacaa tatcacagag    360

ccgcccatgc acttcggtca cgaaaactgg acaaattgta tgaagcatgt cgttaccttg    420

cagctaggtg ccattatgct gcaaaagagc accagcaggc ccttgatgtt cttgacatgg    480

aagagcccat caataaaaga ttatttgaaa aatacttgaa ggacgaaagt ggcttcaaag    540

atccttccag cgactgggaa atgtcacagt cttcaataaa gagttctatc tgtcttctac    600

gcgggaaaat ctatgatgct ctagataacc gaaccctggc tacctacagc tacaaagaag    660

ctttgaagct tgatgtctac tgttttgaag cgttcgatct tttaacatca catcacatgc    720

tgacagcaca agaagaaaaa gaacttcttg aatcactacc ccttagcaag ctgtgtaatg    780

aagaacagga attgctgcgt tttctatttg agaacaaatt gaaaaaatat aataagccta    840

gtgaaacggt catccctgaa tctgtagatg gcttgcaaga gaatctggat gtggtagtgt    900

ctttagctga gagacattat tataactgtg attttaaaat gtgctacaag cttacttctg    960

tagtaatgga gaaagatcct ttccatgcaa gttgtttacc tgtacatata gggacgcttg   1020

tagagctgaa taaagccaat gaacttttct atctttctca taaactggtg gatttatatc   1080

ctagtaatcc tgtgtcttgg tttgcagtgg gatgttacta tctcatggtc ggtcataaaa   1140

atgaacatgc cagaagatat ctcagcaaag ccacaacact tgagaaaacc tatggacctg   1200

catggatagc ctatggacat tcatttgcgg tggagagtga gcacgaccaa gcgatggctg   1260

cttacttcac agcagcacag ctgatgaaag gatggaaaac agccgaaaaa tggtttcttg   1320

atgctttgga aaaaattaaa gcaattggga acgaggtaac agttgacaaa tgggaacctt   1380

tgttgaacaa cttggggcat gtctgcagaa aacttaaaaa gtatgctgag gccttggatt   1440

accaccgtca ggcactggtg ttgattcctc agaacgcatc cacctactct gctattggat   1500

atatccacag tctgatgggc aactttgaaa atgctgtgga ctacttccac acagcccttg   1560

gtcttaggcg agatgataca ttttctgtta caatgcttgg tcattgcatc gaaatgtaca   1620

ttggtgattc tgaagcttat attggagcag acattaaaga caaattaaaa tgttatgact   1680

ttgatgtgca tacaatgaag acactaaaaa acattatttc acctccgtgg gatttcaggg   1740

aatttgaagt agaaaaacag actgcagaag aaacggggct tacgccattg gaaacctcaa   1800

ggaaaactcc agattccaga ccttccttgg aagaaacctt tgaaattgaa atgaatgaaa   1860

gtgacatgat gttagagaca tctatgtcag accacagcac gtgactccag tcagtggtcc   1920

tggtcccact gtcccagtgt aggttagtat tccttcacat cctctccatg gcttaagaat   1980

gtcccacttc ctaacgtgac tccaaactgc atctctacat ttaggaacag agacccgcct   2040

taagagactg gatcgcacac ctttgcaaca gatgtgttct gattctctga acctacaaaa   2100

tagttataca tagtggaata aagaaggtaa accatc                             2136


<210>  3060
<211>  569
<212>  PRT
<213>  Homo sapiens

<400>  3060


Met Asn Leu Glu Arg Leu Arg Lys Arg Val Arg Gln Tyr Leu Asp Gln 
1               5                   10                  15      


Gln Gln Tyr Gln Ser Ala Leu Phe Trp Ala Asp Lys Val Ala Ser Leu 
            20                  25                  30          


Ser Arg Glu Glu Pro Gln Asp Ile Tyr Trp Leu Ala Gln Cys Leu Tyr 
        35                  40                  45              


Leu Thr Ala Gln Tyr His Arg Ala Ala His Ala Leu Arg Ser Arg Lys 
    50                  55                  60                  


Leu Asp Lys Leu Tyr Glu Ala Cys Arg Tyr Leu Ala Ala Arg Cys His 
65                  70                  75                  80  


Tyr Ala Ala Lys Glu His Gln Gln Ala Leu Asp Val Leu Asp Met Glu 
                85                  90                  95      


Glu Pro Ile Asn Lys Arg Leu Phe Glu Lys Tyr Leu Lys Asp Glu Ser 
            100                 105                 110         


Gly Phe Lys Asp Pro Ser Ser Asp Trp Glu Met Ser Gln Ser Ser Ile 
        115                 120                 125             


Lys Ser Ser Ile Cys Leu Leu Arg Gly Lys Ile Tyr Asp Ala Leu Asp 
    130                 135                 140                 


Asn Arg Thr Leu Ala Thr Tyr Ser Tyr Lys Glu Ala Leu Lys Leu Asp 
145                 150                 155                 160 


Val Tyr Cys Phe Glu Ala Phe Asp Leu Leu Thr Ser His His Met Leu 
                165                 170                 175     


Thr Ala Gln Glu Glu Lys Glu Leu Leu Glu Ser Leu Pro Leu Ser Lys 
            180                 185                 190         


Leu Cys Asn Glu Glu Gln Glu Leu Leu Arg Phe Leu Phe Glu Asn Lys 
        195                 200                 205             


Leu Lys Lys Tyr Asn Lys Pro Ser Glu Thr Val Ile Pro Glu Ser Val 
    210                 215                 220                 


Asp Gly Leu Gln Glu Asn Leu Asp Val Val Val Ser Leu Ala Glu Arg 
225                 230                 235                 240 


His Tyr Tyr Asn Cys Asp Phe Lys Met Cys Tyr Lys Leu Thr Ser Val 
                245                 250                 255     


Val Met Glu Lys Asp Pro Phe His Ala Ser Cys Leu Pro Val His Ile 
            260                 265                 270         


Gly Thr Leu Val Glu Leu Asn Lys Ala Asn Glu Leu Phe Tyr Leu Ser 
        275                 280                 285             


His Lys Leu Val Asp Leu Tyr Pro Ser Asn Pro Val Ser Trp Phe Ala 
    290                 295                 300                 


Val Gly Cys Tyr Tyr Leu Met Val Gly His Lys Asn Glu His Ala Arg 
305                 310                 315                 320 


Arg Tyr Leu Ser Lys Ala Thr Thr Leu Glu Lys Thr Tyr Gly Pro Ala 
                325                 330                 335     


Trp Ile Ala Tyr Gly His Ser Phe Ala Val Glu Ser Glu His Asp Gln 
            340                 345                 350         


Ala Met Ala Ala Tyr Phe Thr Ala Ala Gln Leu Met Lys Gly Trp Lys 
        355                 360                 365             


Thr Ala Glu Lys Trp Phe Leu Asp Ala Leu Glu Lys Ile Lys Ala Ile 
    370                 375                 380                 


Gly Asn Glu Val Thr Val Asp Lys Trp Glu Pro Leu Leu Asn Asn Leu 
385                 390                 395                 400 


Gly His Val Cys Arg Lys Leu Lys Lys Tyr Ala Glu Ala Leu Asp Tyr 
                405                 410                 415     


His Arg Gln Ala Leu Val Leu Ile Pro Gln Asn Ala Ser Thr Tyr Ser 
            420                 425                 430         


Ala Ile Gly Tyr Ile His Ser Leu Met Gly Asn Phe Glu Asn Ala Val 
        435                 440                 445             


Asp Tyr Phe His Thr Ala Leu Gly Leu Arg Arg Asp Asp Thr Phe Ser 
    450                 455                 460                 


Val Thr Met Leu Gly His Cys Ile Glu Met Tyr Ile Gly Asp Ser Glu 
465                 470                 475                 480 


Ala Tyr Ile Gly Ala Asp Ile Lys Asp Lys Leu Lys Cys Tyr Asp Phe 
                485                 490                 495     


Asp Val His Thr Met Lys Thr Leu Lys Asn Ile Ile Ser Pro Pro Trp 
            500                 505                 510         


Asp Phe Arg Glu Phe Glu Val Glu Lys Gln Thr Ala Glu Glu Thr Gly 
        515                 520                 525             


Leu Thr Pro Leu Glu Thr Ser Arg Lys Thr Pro Asp Ser Arg Pro Ser 
    530                 535                 540                 


Leu Glu Glu Thr Phe Glu Ile Glu Met Asn Glu Ser Asp Met Met Leu 
545                 550                 555                 560 


Glu Thr Ser Met Ser Asp His Ser Thr 
                565                 

<210>  3061
<211>  2253
<212>  DNA
<213>  Homo sapiens

<400>  3061
ctgggcagtg cacggggcct gggtgggggg tgcgggtgtg ggtggggacc tgcggccttc     60

gagtccgcgg ccttcgagtc ctggggcggc ggcggcggct gcaggcacgg gcacgggcac    120

ggggcggggt gcttagggtg caggaggcgc gcgcctagcg gcggagtgtg gcgtgaggcc    180

gggcccgcgc cgccatgaac ctagagcggc tgcggaagcg cgtccggcag tacctcgacc    240

agcaacagta tcaaagtgct ctattttggg cagataaagt agcttcactc tctcgtgaag    300

aaccccagga catctattgg ttggctcagt gtctttacct gacagcacaa tatcacagag    360

ccgcccatgc acttcggtca cgaaaactgg acaaattgta tgaagcatgt cgttaccttg    420

cagctaggtg ccattatgct gcaaaagagc accagcaggc ccttgatgtt cttgacatgg    480

aagagcccat caataaaaga ttatttgaaa aatacttgaa ggacgaaagt ggcttcaaag    540

atccttccag cgactgggaa atgtcacagt cttcaataaa gagttctatc tgtcttctac    600

gcgggaaaat ctatgatgct ctagataacc gaaccctggc tacctacagc tacaaagaag    660

ctttgaagct tgatgtctac tgttttgaag cgttcgatct tttaacatca catcacatgc    720

tgacagcaca agaagaaaaa gaacttcttg aatcactacc ccttagcaag ctgtgtaatg    780

aagaacagga attgctgcgt tttctatttg agaacaaatt gaaaaaatat aataagccta    840

gtgaaacggt catccctgaa tctgtagatg gcttgcaaga gaatctggat gtggtagtgt    900

ctttagctga gagacattat tataactgtg attttaaaat gtgctacaag cttacttctg    960

tagtaatgga gaaagatcct ttccatgcaa gttgtttacc tgtacatata gggacgcttg   1020

tagagctgaa taaagccaat gaacttttct atctttctca taaactggtg gatttatatc   1080

ctagtaatcc tgtgtcttgg tttgcagtgg gatgttacta tctcatggtc ggtcataaaa   1140

atgaacatgc cagaagatat ctcagcaaag ccacaacact tgagaaaacc tatggacctg   1200

catggatagc ctatggacat tcatttgcgg tggagagtga gcacgaccaa gcgatggctg   1260

cttacttcac agcagcacag ctgatgaaag ggtgtcattt gcctatgctg tatattggat   1320

tagaatatgg tttgaccaat aactcaaaac tagctgaaag gttcttcagc caagctctga   1380

gcattgcacc ggaagaccct tttgttatgc atgaggtcgg cgtggttgca tttcagaatg   1440

gagaatggaa aacagccgaa aaatggtttc ttgatgcttt ggaaaaaatt aaagcaattg   1500

ggaacgaggt aacagttgac aaatgggaac ctttgttgaa caacttgggg catgtctgca   1560

gaaaacttaa aaagtatgct gaggccttgg attaccaccg tcaggcactg gtgttgattc   1620

ctcagaacgc atccacctac tctgctattg gatatatcca cagtctgatg ggcaactttg   1680

aaaatgctgt ggactacttc cacacagccc ttggtcttag gcgagatgat acattttctg   1740

ttacaatgct tggtcattgc atcgaaatgt acattggtga ttctgaagct tatattggag   1800

cagacattaa agacaaatta aaatgttatg actttgatgt gcatacaatg aagacactaa   1860

aaaacattat ttcacctccg tgggatttca gggaatttga agtagaaaaa cagactgcag   1920

aagaaacggg gcttacgcca ttggaaacct caaggaaaac tccagattcc agaccttcct   1980

tggaagaaac ctttgaaatt gaaatgaatg aaagtgacat gatgttagag acatctatgt   2040

cagaccacag cacgtgactc cagtcagtgg tcctggtccc actgtcccag tgtaggaaca   2100

gagacccgcc ttaagagact ggatcgcaca cctttgcaac agatgtgttc tgattctctg   2160

aacctacaaa atagttatac atagtggaat aaagaaggta aaccatctgt tatgtctttt   2220

tttttctttt ccaataaact tttattttgg act                                2253


<210>  3062
<211>  620
<212>  PRT
<213>  Homo sapiens

<400>  3062


Met Asn Leu Glu Arg Leu Arg Lys Arg Val Arg Gln Tyr Leu Asp Gln 
1               5                   10                  15      


Gln Gln Tyr Gln Ser Ala Leu Phe Trp Ala Asp Lys Val Ala Ser Leu 
            20                  25                  30          


Ser Arg Glu Glu Pro Gln Asp Ile Tyr Trp Leu Ala Gln Cys Leu Tyr 
        35                  40                  45              


Leu Thr Ala Gln Tyr His Arg Ala Ala His Ala Leu Arg Ser Arg Lys 
    50                  55                  60                  


Leu Asp Lys Leu Tyr Glu Ala Cys Arg Tyr Leu Ala Ala Arg Cys His 
65                  70                  75                  80  


Tyr Ala Ala Lys Glu His Gln Gln Ala Leu Asp Val Leu Asp Met Glu 
                85                  90                  95      


Glu Pro Ile Asn Lys Arg Leu Phe Glu Lys Tyr Leu Lys Asp Glu Ser 
            100                 105                 110         


Gly Phe Lys Asp Pro Ser Ser Asp Trp Glu Met Ser Gln Ser Ser Ile 
        115                 120                 125             


Lys Ser Ser Ile Cys Leu Leu Arg Gly Lys Ile Tyr Asp Ala Leu Asp 
    130                 135                 140                 


Asn Arg Thr Leu Ala Thr Tyr Ser Tyr Lys Glu Ala Leu Lys Leu Asp 
145                 150                 155                 160 


Val Tyr Cys Phe Glu Ala Phe Asp Leu Leu Thr Ser His His Met Leu 
                165                 170                 175     


Thr Ala Gln Glu Glu Lys Glu Leu Leu Glu Ser Leu Pro Leu Ser Lys 
            180                 185                 190         


Leu Cys Asn Glu Glu Gln Glu Leu Leu Arg Phe Leu Phe Glu Asn Lys 
        195                 200                 205             


Leu Lys Lys Tyr Asn Lys Pro Ser Glu Thr Val Ile Pro Glu Ser Val 
    210                 215                 220                 


Asp Gly Leu Gln Glu Asn Leu Asp Val Val Val Ser Leu Ala Glu Arg 
225                 230                 235                 240 


His Tyr Tyr Asn Cys Asp Phe Lys Met Cys Tyr Lys Leu Thr Ser Val 
                245                 250                 255     


Val Met Glu Lys Asp Pro Phe His Ala Ser Cys Leu Pro Val His Ile 
            260                 265                 270         


Gly Thr Leu Val Glu Leu Asn Lys Ala Asn Glu Leu Phe Tyr Leu Ser 
        275                 280                 285             


His Lys Leu Val Asp Leu Tyr Pro Ser Asn Pro Val Ser Trp Phe Ala 
    290                 295                 300                 


Val Gly Cys Tyr Tyr Leu Met Val Gly His Lys Asn Glu His Ala Arg 
305                 310                 315                 320 


Arg Tyr Leu Ser Lys Ala Thr Thr Leu Glu Lys Thr Tyr Gly Pro Ala 
                325                 330                 335     


Trp Ile Ala Tyr Gly His Ser Phe Ala Val Glu Ser Glu His Asp Gln 
            340                 345                 350         


Ala Met Ala Ala Tyr Phe Thr Ala Ala Gln Leu Met Lys Gly Cys His 
        355                 360                 365             


Leu Pro Met Leu Tyr Ile Gly Leu Glu Tyr Gly Leu Thr Asn Asn Ser 
    370                 375                 380                 


Lys Leu Ala Glu Arg Phe Phe Ser Gln Ala Leu Ser Ile Ala Pro Glu 
385                 390                 395                 400 


Asp Pro Phe Val Met His Glu Val Gly Val Val Ala Phe Gln Asn Gly 
                405                 410                 415     


Glu Trp Lys Thr Ala Glu Lys Trp Phe Leu Asp Ala Leu Glu Lys Ile 
            420                 425                 430         


Lys Ala Ile Gly Asn Glu Val Thr Val Asp Lys Trp Glu Pro Leu Leu 
        435                 440                 445             


Asn Asn Leu Gly His Val Cys Arg Lys Leu Lys Lys Tyr Ala Glu Ala 
    450                 455                 460                 


Leu Asp Tyr His Arg Gln Ala Leu Val Leu Ile Pro Gln Asn Ala Ser 
465                 470                 475                 480 


Thr Tyr Ser Ala Ile Gly Tyr Ile His Ser Leu Met Gly Asn Phe Glu 
                485                 490                 495     


Asn Ala Val Asp Tyr Phe His Thr Ala Leu Gly Leu Arg Arg Asp Asp 
            500                 505                 510         


Thr Phe Ser Val Thr Met Leu Gly His Cys Ile Glu Met Tyr Ile Gly 
        515                 520                 525             


Asp Ser Glu Ala Tyr Ile Gly Ala Asp Ile Lys Asp Lys Leu Lys Cys 
    530                 535                 540                 


Tyr Asp Phe Asp Val His Thr Met Lys Thr Leu Lys Asn Ile Ile Ser 
545                 550                 555                 560 


Pro Pro Trp Asp Phe Arg Glu Phe Glu Val Glu Lys Gln Thr Ala Glu 
                565                 570                 575     


Glu Thr Gly Leu Thr Pro Leu Glu Thr Ser Arg Lys Thr Pro Asp Ser 
            580                 585                 590         


Arg Pro Ser Leu Glu Glu Thr Phe Glu Ile Glu Met Asn Glu Ser Asp 
        595                 600                 605             


Met Met Leu Glu Thr Ser Met Ser Asp His Ser Thr 
    610                 615                 620 

<210>  3063
<211>  2337
<212>  DNA
<213>  Homo sapiens

<400>  3063
ctgggcagtg cacggggcct gggtgggggg tgcgggtgtg ggtggggacc tgcggccttc     60

gagtccgcgg ccttcgagtc ctggggcggc ggcggcggct gcaggcacgg gcacgggcac    120

ggggcggggt gcttagggtg caggaggcgc gcgcctagcg gcggagtgtg gcgtgaggcc    180

gggcccgcgc cgccatgaac ctagagcggc tgcggaagcg cgtccggcag tacctcgacc    240

agcaacagta tcaaagtgct ctattttggg cagataaagt agcttcactc tctcgtgaag    300

aaccccagga catctattgg ttggctcagt gtctttacct gacagcacaa tatcacagag    360

ccgcccatgc acttcggtca cgaaaactgg acaaattgta tgaagcatgt cgttaccttg    420

cagctaggtg ccattatgct gcaaaagagc accagcaggc ccttgatgtt cttgacatgg    480

aagagcccat caataaaaga ttatttgaaa aatacttgaa ggacgaaagt ggcttcaaag    540

atccttccag cgactgggaa atgtcacagt cttcaataaa gagttctatc tgtcttctac    600

gcgggaaaat ctatgatgct ctagataacc gaaccctggc tacctacagc tacaaagaag    660

ctttgaagct tgatgtctac tgttttgaag cgttcgatct tttaacatca catcacatgc    720

tgacagcaca agaagaaaaa gaacttcttg aatcactacc ccttagcaag ctgtgtaatg    780

aagaacagga attgctgcgt tttctatttg agaacaaatt gaaaaaatat aataagccta    840

gtgaaacggt catccctgaa tctgtagatg gcttgcaaga gaatctggat gtggtagtgt    900

ctttagctga gagacattat tataactgtg attttaaaat gtgctacaag cttacttctg    960

tagtaatgga gaaagatcct ttccatgcaa gttgtttacc tgtacatata gggacgcttg   1020

tagagctgaa taaagccaat gaacttttct atctttctca taaactggtg gatttatatc   1080

ctagtaatcc tgtgtcttgg tttgcagtgg gatgttacta tctcatggtc ggtcataaaa   1140

atgaacatgc cagaagatat ctcagcaaag ccacaacact tgagaaaacc tatggacctg   1200

catggatagc ctatggacat tcatttgcgg tggagagtga gcacgaccaa gcgatggctg   1260

cttacttcac agcagcacag ctgatgaaag ggtgtcattt gcctatgctg tatattggat   1320

tagaatatgg tttgaccaat aactcaaaac tagctgaaag gttcttcagc caagctctga   1380

gcattgcacc ggaagaccct tttgttatgc atgaggtcgg cgtggttgca tttcagaatg   1440

gagaatggaa aacagccgaa aaatggtttc ttgatgcttt ggaaaaaatt aaagcaattg   1500

ggaacgaggt aacagttgac aaatgggaac ctttgttgaa caacttgggg catgtctgca   1560

gaaaacttaa aaagtatgct gaggccttgg attaccaccg tcaggcactg gtgttgattc   1620

ctcagaacgc atccacctac tctgctattg gatatatcca cagtctgatg ggcaactttg   1680

aaaatgctgt ggactacttc cacacagccc ttggtcttag gcgagatgat acattttctg   1740

ttacaatgct tggtcattgc atcgaaatgt acattggtga ttctgaagct tatattggag   1800

cagacattaa agacaaatta aaatgttatg actttgatgt gcatacaatg aagacactaa   1860

aaaacattat ttcacctccg tgggatttca gggaatttga agtagaaaaa cagactgcag   1920

aagaaacggg gcttacgcca ttggaaacct caaggaaaac tccagattcc agaccttcct   1980

tggaagaaac ctttgaaatt gaaatgaatg aaagtgacat gatgttagag acatctatgt   2040

cagaccacag cacgtgactc cagtcagtgg tcctggtccc actgtcccag tgtaggttag   2100

tattccttca catcctctcc atggcttaag aatgtcccac ttcctaacgt gactccaaac   2160

tgcatctcta catttaggaa cagagacccg ccttaagaga ctggatcgca cacctttgca   2220

acagatgtgt tctgattctc tgaacctaca aaatagttat acatagtgga ataaagaagg   2280

taaaccatct gttatgtctt tttttttctt ttccaataaa cttttatttt ggactaa      2337


<210>  3064
<211>  620
<212>  PRT
<213>  Homo sapiens

<400>  3064


Met Asn Leu Glu Arg Leu Arg Lys Arg Val Arg Gln Tyr Leu Asp Gln 
1               5                   10                  15      


Gln Gln Tyr Gln Ser Ala Leu Phe Trp Ala Asp Lys Val Ala Ser Leu 
            20                  25                  30          


Ser Arg Glu Glu Pro Gln Asp Ile Tyr Trp Leu Ala Gln Cys Leu Tyr 
        35                  40                  45              


Leu Thr Ala Gln Tyr His Arg Ala Ala His Ala Leu Arg Ser Arg Lys 
    50                  55                  60                  


Leu Asp Lys Leu Tyr Glu Ala Cys Arg Tyr Leu Ala Ala Arg Cys His 
65                  70                  75                  80  


Tyr Ala Ala Lys Glu His Gln Gln Ala Leu Asp Val Leu Asp Met Glu 
                85                  90                  95      


Glu Pro Ile Asn Lys Arg Leu Phe Glu Lys Tyr Leu Lys Asp Glu Ser 
            100                 105                 110         


Gly Phe Lys Asp Pro Ser Ser Asp Trp Glu Met Ser Gln Ser Ser Ile 
        115                 120                 125             


Lys Ser Ser Ile Cys Leu Leu Arg Gly Lys Ile Tyr Asp Ala Leu Asp 
    130                 135                 140                 


Asn Arg Thr Leu Ala Thr Tyr Ser Tyr Lys Glu Ala Leu Lys Leu Asp 
145                 150                 155                 160 


Val Tyr Cys Phe Glu Ala Phe Asp Leu Leu Thr Ser His His Met Leu 
                165                 170                 175     


Thr Ala Gln Glu Glu Lys Glu Leu Leu Glu Ser Leu Pro Leu Ser Lys 
            180                 185                 190         


Leu Cys Asn Glu Glu Gln Glu Leu Leu Arg Phe Leu Phe Glu Asn Lys 
        195                 200                 205             


Leu Lys Lys Tyr Asn Lys Pro Ser Glu Thr Val Ile Pro Glu Ser Val 
    210                 215                 220                 


Asp Gly Leu Gln Glu Asn Leu Asp Val Val Val Ser Leu Ala Glu Arg 
225                 230                 235                 240 


His Tyr Tyr Asn Cys Asp Phe Lys Met Cys Tyr Lys Leu Thr Ser Val 
                245                 250                 255     


Val Met Glu Lys Asp Pro Phe His Ala Ser Cys Leu Pro Val His Ile 
            260                 265                 270         


Gly Thr Leu Val Glu Leu Asn Lys Ala Asn Glu Leu Phe Tyr Leu Ser 
        275                 280                 285             


His Lys Leu Val Asp Leu Tyr Pro Ser Asn Pro Val Ser Trp Phe Ala 
    290                 295                 300                 


Val Gly Cys Tyr Tyr Leu Met Val Gly His Lys Asn Glu His Ala Arg 
305                 310                 315                 320 


Arg Tyr Leu Ser Lys Ala Thr Thr Leu Glu Lys Thr Tyr Gly Pro Ala 
                325                 330                 335     


Trp Ile Ala Tyr Gly His Ser Phe Ala Val Glu Ser Glu His Asp Gln 
            340                 345                 350         


Ala Met Ala Ala Tyr Phe Thr Ala Ala Gln Leu Met Lys Gly Cys His 
        355                 360                 365             


Leu Pro Met Leu Tyr Ile Gly Leu Glu Tyr Gly Leu Thr Asn Asn Ser 
    370                 375                 380                 


Lys Leu Ala Glu Arg Phe Phe Ser Gln Ala Leu Ser Ile Ala Pro Glu 
385                 390                 395                 400 


Asp Pro Phe Val Met His Glu Val Gly Val Val Ala Phe Gln Asn Gly 
                405                 410                 415     


Glu Trp Lys Thr Ala Glu Lys Trp Phe Leu Asp Ala Leu Glu Lys Ile 
            420                 425                 430         


Lys Ala Ile Gly Asn Glu Val Thr Val Asp Lys Trp Glu Pro Leu Leu 
        435                 440                 445             


Asn Asn Leu Gly His Val Cys Arg Lys Leu Lys Lys Tyr Ala Glu Ala 
    450                 455                 460                 


Leu Asp Tyr His Arg Gln Ala Leu Val Leu Ile Pro Gln Asn Ala Ser 
465                 470                 475                 480 


Thr Tyr Ser Ala Ile Gly Tyr Ile His Ser Leu Met Gly Asn Phe Glu 
                485                 490                 495     


Asn Ala Val Asp Tyr Phe His Thr Ala Leu Gly Leu Arg Arg Asp Asp 
            500                 505                 510         


Thr Phe Ser Val Thr Met Leu Gly His Cys Ile Glu Met Tyr Ile Gly 
        515                 520                 525             


Asp Ser Glu Ala Tyr Ile Gly Ala Asp Ile Lys Asp Lys Leu Lys Cys 
    530                 535                 540                 


Tyr Asp Phe Asp Val His Thr Met Lys Thr Leu Lys Asn Ile Ile Ser 
545                 550                 555                 560 


Pro Pro Trp Asp Phe Arg Glu Phe Glu Val Glu Lys Gln Thr Ala Glu 
                565                 570                 575     


Glu Thr Gly Leu Thr Pro Leu Glu Thr Ser Arg Lys Thr Pro Asp Ser 
            580                 585                 590         


Arg Pro Ser Leu Glu Glu Thr Phe Glu Ile Glu Met Asn Glu Ser Asp 
        595                 600                 605             


Met Met Leu Glu Thr Ser Met Ser Asp His Ser Thr 
    610                 615                 620 

<210>  3065
<211>  2184
<212>  DNA
<213>  Homo sapiens

<400>  3065
ctgggcagtg cacggggcct gggtgggggg tgcgggtgtg ggtggggacc tgcggccttc     60

gagtccgcgg ccttcgagtc ctggggcggc ggcggcggct gcaggcacgg gcacgggcac    120

ggggcggggt gcttagggtg caggaggcgc gcgcctagcg gcggagtgtg gcgtgaggcc    180

gggcccgcgc cgccatgaac ctagagcggc tgcggaagcg cgtccggcag tacctcgacc    240

agcaacagta tcaaagtgct ctattttggg cagataaagt agcttcactc tctcgtgaag    300

aaccccagga catctattgg ttggctcagt gtctttacct gacagcacaa tatcacagag    360

ccgcccatgc acttcggtca cgaaaactgg acaaattgta tgaagcatgt cgttaccttg    420

cagctaggtg ccattatgct gcaaaagagc accagcaggc ccttgatgtt cttgacatgg    480

aagagcccat caataaaaga ttatttgaaa aatacttgaa ggacgaaagt ggcttcaaag    540

atccttccag cgactgggaa atgtcacagt cttcaataaa gagttctatc tgtcttctac    600

gcgggaaaat ctatgatgct ctagataacc gaaccctggc tacctacagc tacaaagaag    660

ctttgaagct tgatgtctac tgttttgaag cgttcgatct tttaacatca catcacatgc    720

tgacagcaca agaagaaaaa gaacttcttg aatcactacc ccttagcaag ctgtgtaatg    780

aagaacagga attgctgcgt tttctatttg agaacaaatt gaaaaaatat aataagccta    840

gtgaaacggt catccctgaa tctgtagatg gcttgcaaga gaatctggat gtggtagtgt    900

ctttagctga gagacattat tataactgtg attttaaaat gtgctacaag cttacttctg    960

tagtaatgga gaaagatcct ttccatgcaa gttgtttacc tgtacatata gggacgcttg   1020

tagagctgaa taaagccaat gaacttttct atctttctca taaactggtg gatttatatc   1080

ctagtaatcc tgtgtcttgg tttgcagtgg gatgttacta tctcatggtc ggtcataaaa   1140

atgaacatgc cagaagatat ctcagcaaag ccacaacact tgagaaaacc tatggacctg   1200

catggatagc ctatggacat tcatttgcgg tggagagtga gcacgaccaa gcgatggctg   1260

cttacttcac agcagcacag ctgatgaaag gatggaaaac agccgaaaaa tggtttcttg   1320

atgctttgga aaaaattaaa gcaattggga acgaggtaac agttgacaaa tgggaacctt   1380

tgttgaacaa cttggggcat gtctgcagaa aacttaaaaa gtatgctgag gccttggatt   1440

accaccgtca ggcactggtg ttgattcctc agaacgcatc cacctactct gctattggat   1500

atatccacag tctgatgggc aactttgaaa atgctgtgga ctacttccac acagcccttg   1560

gtcttaggcg agatgataca ttttctgtta caatgcttgg tcattgcatc gaaatgtaca   1620

ttggtgattc tgaagcttat attggagcag acattaaaga caaattaaaa tgttatgact   1680

ttgatgtgca tacaatgaag acactaaaaa acattatttc acctccgtgg gatttcaggg   1740

aatttgaagt agaaaaacag actgcagaag aaacggggct tacgccattg gaaacctcaa   1800

ggaaaactcc agattccaga ccttccttgg aagaaacctt tgaaattgaa atgaatgaaa   1860

gtgacatgat gttagagaca tctatgtcag accacagcac gtgactccag tcagtggtcc   1920

tggtcccact gtcccagtgt aggttagtat tccttcacat cctctccatg gcttaagaat   1980

gtcccacttc ctaacgtgac tccaaactgc atctctacat ttaggaacag agacccgcct   2040

taagagactg gatcgcacac ctttgcaaca gatgtgttct gattctctga acctacaaaa   2100

tagttataca tagtggaata aagaaggtaa accatctgtt atgtcttttt ttttcttttc   2160

caataaactt ttattttgga ctaa                                          2184


<210>  3066
<211>  569
<212>  PRT
<213>  Homo sapiens

<400>  3066


Met Asn Leu Glu Arg Leu Arg Lys Arg Val Arg Gln Tyr Leu Asp Gln 
1               5                   10                  15      


Gln Gln Tyr Gln Ser Ala Leu Phe Trp Ala Asp Lys Val Ala Ser Leu 
            20                  25                  30          


Ser Arg Glu Glu Pro Gln Asp Ile Tyr Trp Leu Ala Gln Cys Leu Tyr 
        35                  40                  45              


Leu Thr Ala Gln Tyr His Arg Ala Ala His Ala Leu Arg Ser Arg Lys 
    50                  55                  60                  


Leu Asp Lys Leu Tyr Glu Ala Cys Arg Tyr Leu Ala Ala Arg Cys His 
65                  70                  75                  80  


Tyr Ala Ala Lys Glu His Gln Gln Ala Leu Asp Val Leu Asp Met Glu 
                85                  90                  95      


Glu Pro Ile Asn Lys Arg Leu Phe Glu Lys Tyr Leu Lys Asp Glu Ser 
            100                 105                 110         


Gly Phe Lys Asp Pro Ser Ser Asp Trp Glu Met Ser Gln Ser Ser Ile 
        115                 120                 125             


Lys Ser Ser Ile Cys Leu Leu Arg Gly Lys Ile Tyr Asp Ala Leu Asp 
    130                 135                 140                 


Asn Arg Thr Leu Ala Thr Tyr Ser Tyr Lys Glu Ala Leu Lys Leu Asp 
145                 150                 155                 160 


Val Tyr Cys Phe Glu Ala Phe Asp Leu Leu Thr Ser His His Met Leu 
                165                 170                 175     


Thr Ala Gln Glu Glu Lys Glu Leu Leu Glu Ser Leu Pro Leu Ser Lys 
            180                 185                 190         


Leu Cys Asn Glu Glu Gln Glu Leu Leu Arg Phe Leu Phe Glu Asn Lys 
        195                 200                 205             


Leu Lys Lys Tyr Asn Lys Pro Ser Glu Thr Val Ile Pro Glu Ser Val 
    210                 215                 220                 


Asp Gly Leu Gln Glu Asn Leu Asp Val Val Val Ser Leu Ala Glu Arg 
225                 230                 235                 240 


His Tyr Tyr Asn Cys Asp Phe Lys Met Cys Tyr Lys Leu Thr Ser Val 
                245                 250                 255     


Val Met Glu Lys Asp Pro Phe His Ala Ser Cys Leu Pro Val His Ile 
            260                 265                 270         


Gly Thr Leu Val Glu Leu Asn Lys Ala Asn Glu Leu Phe Tyr Leu Ser 
        275                 280                 285             


His Lys Leu Val Asp Leu Tyr Pro Ser Asn Pro Val Ser Trp Phe Ala 
    290                 295                 300                 


Val Gly Cys Tyr Tyr Leu Met Val Gly His Lys Asn Glu His Ala Arg 
305                 310                 315                 320 


Arg Tyr Leu Ser Lys Ala Thr Thr Leu Glu Lys Thr Tyr Gly Pro Ala 
                325                 330                 335     


Trp Ile Ala Tyr Gly His Ser Phe Ala Val Glu Ser Glu His Asp Gln 
            340                 345                 350         


Ala Met Ala Ala Tyr Phe Thr Ala Ala Gln Leu Met Lys Gly Trp Lys 
        355                 360                 365             


Thr Ala Glu Lys Trp Phe Leu Asp Ala Leu Glu Lys Ile Lys Ala Ile 
    370                 375                 380                 


Gly Asn Glu Val Thr Val Asp Lys Trp Glu Pro Leu Leu Asn Asn Leu 
385                 390                 395                 400 


Gly His Val Cys Arg Lys Leu Lys Lys Tyr Ala Glu Ala Leu Asp Tyr 
                405                 410                 415     


His Arg Gln Ala Leu Val Leu Ile Pro Gln Asn Ala Ser Thr Tyr Ser 
            420                 425                 430         


Ala Ile Gly Tyr Ile His Ser Leu Met Gly Asn Phe Glu Asn Ala Val 
        435                 440                 445             


Asp Tyr Phe His Thr Ala Leu Gly Leu Arg Arg Asp Asp Thr Phe Ser 
    450                 455                 460                 


Val Thr Met Leu Gly His Cys Ile Glu Met Tyr Ile Gly Asp Ser Glu 
465                 470                 475                 480 


Ala Tyr Ile Gly Ala Asp Ile Lys Asp Lys Leu Lys Cys Tyr Asp Phe 
                485                 490                 495     


Asp Val His Thr Met Lys Thr Leu Lys Asn Ile Ile Ser Pro Pro Trp 
            500                 505                 510         


Asp Phe Arg Glu Phe Glu Val Glu Lys Gln Thr Ala Glu Glu Thr Gly 
        515                 520                 525             


Leu Thr Pro Leu Glu Thr Ser Arg Lys Thr Pro Asp Ser Arg Pro Ser 
    530                 535                 540                 


Leu Glu Glu Thr Phe Glu Ile Glu Met Asn Glu Ser Asp Met Met Leu 
545                 550                 555                 560 


Glu Thr Ser Met Ser Asp His Ser Thr 
                565                 

<210>  3067
<211>  904
<212>  DNA
<213>  Homo sapiens

<400>  3067
agtgcacggg gcctgggtgg ggggtgcggg tgtgggtggg gacctgcggc cttcgagtcc     60

gcggccttcg agtcctgggg cggcggcggc ggctgcaggc acgggcacgg gcacggggcg    120

gggtgcttag ggtgcaggag gcgcgcgcct agcggcggag tgtggcgtga ggccgggccc    180

gcgccgccat gaacctagag cggctgcgga agcgcgtccg gcagtacctc gaccagaaga    240

accccaggac atctattggt tggctcagtg tctttacctg acagcacaat atcacagagc    300

cgcccatgca cttcggtcac gaaaactgga caaattgtat gaagcatgtc gttaccttgc    360

agctaggtgc cattatgctg caaaagagca ccagcaggcc cttgatgttc ttgacatgga    420

agagcccatc aataaaagat tatttgaaaa atacttgaag gacgaaagtg gcttcaaaga    480

tccttccagc gactgggaaa tgtcacagtc ttcaataaag agttctatct gtcttctacg    540

cgggaaaatc tatgatgctc tagataaccg aaccctggct acctacagct acaaagaagc    600

tttgaagctt gatgtctact gttttgaagc gttcgatctt ttaacatcac atcacatgct    660

gacagcacaa gaagaaaaag aacttcttga atcactaccc cttagcaagc tgtgtaatga    720

agaacaggaa ttgctgcgtt ttctatttga gaacaaattg aaaaaatata ataagcctag    780

tgaaacggtc atccctgaat ctgtagatgg cttgcaagag aatctggatg tggtagtgtc    840

tttagctgag agacattatt ataactgtga ttttaaaatg tgctacaagc ttacttctgt    900

gtaa                                                                 904


<210>  3068
<211>  162
<212>  PRT
<213>  Homo sapiens

<400>  3068


Met Glu Glu Pro Ile Asn Lys Arg Leu Phe Glu Lys Tyr Leu Lys Asp 
1               5                   10                  15      


Glu Ser Gly Phe Lys Asp Pro Ser Ser Asp Trp Glu Met Ser Gln Ser 
            20                  25                  30          


Ser Ile Lys Ser Ser Ile Cys Leu Leu Arg Gly Lys Ile Tyr Asp Ala 
        35                  40                  45              


Leu Asp Asn Arg Thr Leu Ala Thr Tyr Ser Tyr Lys Glu Ala Leu Lys 
    50                  55                  60                  


Leu Asp Val Tyr Cys Phe Glu Ala Phe Asp Leu Leu Thr Ser His His 
65                  70                  75                  80  


Met Leu Thr Ala Gln Glu Glu Lys Glu Leu Leu Glu Ser Leu Pro Leu 
                85                  90                  95      


Ser Lys Leu Cys Asn Glu Glu Gln Glu Leu Leu Arg Phe Leu Phe Glu 
            100                 105                 110         


Asn Lys Leu Lys Lys Tyr Asn Lys Pro Ser Glu Thr Val Ile Pro Glu 
        115                 120                 125             


Ser Val Asp Gly Leu Gln Glu Asn Leu Asp Val Val Val Ser Leu Ala 
    130                 135                 140                 


Glu Arg His Tyr Tyr Asn Cys Asp Phe Lys Met Cys Tyr Lys Leu Thr 
145                 150                 155                 160 


Ser Val 
        

<210>  3069
<211>  3429
<212>  DNA
<213>  Homo sapiens

<400>  3069
agtgcacggg gcctgggtgg ggggtgcggg tgtgggtggg gacctgcggc cttcgagtcc     60

gcggccttcg agtcctgggg cggcggcggc ggctgcaggc acgggcacgg gcacggggcg    120

gggtgcttag ggtgcaggag gcgcgcgcct agcggcggag tgtggcgtga ggccgggccc    180

gcgccgccat gaacctagag cggctgcgga agcgcgtccg gcagtacctc gaccagcaac    240

agtatcaaag tgctctattt tgggcagata aagtagcttc actctctcgt gaagaacccc    300

aggacatcta ttggttggct cagtgtcttt acctgacagc acaatatcac agagccgccc    360

atgcacttcg gtcacgaaaa ctggacaaat tgtatgaagc atgtcgttac cttgcagcta    420

ggtgccatta tgctgcaaaa gagcaccagc aggcccttga tgttcttgac atggaagagc    480

ccatcaataa aagattattt gaaaaatact tgaaggacga aagtggcttc aaagatcctt    540

ccagcgactg ggaaatgtca cagtcttcaa taaagagttc tatctgtctt ctacgcggga    600

aaatctatga tgctctagat aaccgaaccc tggctaccta cagctacaaa gaagctttga    660

agcttgatgt ctactgtttt gaagcgttcg atcttttaac atcacatcac atgctgacag    720

cacaagaagg tttggaaact caggcttttt tgttttatgt ttagcaaaat taatattgtt    780

tggatttttt gcctctgaaa tcttctaagt caacaacagg ccacatacag gtttaaatag    840

acctactcac tttcttaatg tcttcaaatg taaagcacgt tgcagaatgc agtattgtac    900

ggtgccttgt gctgtccgaa tctagggatt gtgataggaa gaggccatct ttttgagaag    960

tgattgagat agtataaacc aggatttcag tatctcatgc agtgattctc aaccgtgttg   1020

ctctttacat ccttgggaag acagagaaac atccatgtcc agttcccaac tccagagcag   1080

atgctttaaa gctcccaggt gatcctaatg taccacaggc actgagaatc agtccaagta   1140

tgttggcagt ggtgtgaggt gcgtcaacaa gggaaacaga aaatagagtg gttggattaa   1200

tgggattcta acatatttta gcctagtgca gtggttctca accaaccaga gtgattttgc   1260

cgccccctgc cccgggaaca gttggcaatg tctggagatg ttgtttgtca cagcttaggg   1320

gcagggaggg aggttgagag gttgctgctg gtatctagtg gttagtggcc agaggtcctg   1380

cttagcacct gcagtacaca ggctcccctg ttcccagcag agcaagatcc acgcagtcag   1440

gagtgcggag gctggtggtt cttaggtgac aagagccacc tggggacctg cctcagccct   1500

gaaagagtag cctccaccca ccagatgatt cccgtcttca ggcctggagc cactgtgtca   1560

gcttctgttg cacattttga tcttatgttc tcttttgagt ttgatttact tagaccaaga   1620

actgtagaat catattttta gttgttggct ttttcccctc tataaatatt atgaggatat   1680

tctttttttt ctcaccattt ttaagaaaaa gaacttcttg aatcactacc ccttagcaag   1740

ctgtgtaatg aagaacagga attgctgcgt tttctatttg agaacaaatt gaaaaaagta   1800

agtaaaacca aagagttagc acttgcttta tgtaaatatc ttattccata aaatttggca   1860

tctagtctta tattaagttt tcaaaattaa aactttttaa atttagcaca tttttaagaa   1920

tagagcgttt aagatacata agattccaaa aaaaaaaagc tttcaaaaat acctttttcc   1980

tctgaaagac tccttatact aaaagattga attaccaagt aaatgtaaat ggaatggtgt   2040

tgcatggaaa tgaagatttt tttgttatgc ttcctgaatg tttactttga gaaatacgtc   2100

ccgctgtgga attctgttct aaaattgaga agggaattaa acttactgag aggagtactt   2160

ataaaaccta aagttataag ttttcagagg ctctcacatt tgttcttgta aatgttttaa   2220

ccacttgggc caaacacaaa ttgaatccac attttatttt gtttttgctc attgagttta   2280

tgtttacatt tctatgtgtt tcagtataat aagcctagtg aaacggtcat ccctgaatct   2340

gtagatggct tgcaagagaa tctggatgtg gtagtgtctt tagctgagag acattattat   2400

aactgtgatt ttaaaatgtg ctacaagctt acttctgtgt aagtatatcc atccattttt   2460

ctgtaggaac atggagttca ctccatctta cctaggtgat tcacggacgt gctctctgaa   2520

taatcttgaa ctagatgata atttaagtta tctttaccaa ttgtagagca ctgaacaggg   2580

tgctgtctta aaagagcaat ttacagacat gaatttgtgc atatttgtag atttattaca   2640

ttaacttggg agggatatac atgttgctct tactgatctt gataatttgc aagtttgaaa   2700

attccatttt ggcacattgt tttgtaaaat ttattctcaa ttatgagact cacactgtag   2760

atactaggtg tttaatatgc tgcacgcagt agctaagcca tctcccacat gtatcagttt   2820

tccagtgtac ctaatttaaa ctttagctaa atgacatatg ctattttttg tagatcttgg   2880

ttcggtttaa aatccttgaa attacaaaaa ttttaattgg caaatacaca taacctattt   2940

attagtttgg tgcaaaagta attgcagttt ttgctgttga acgtagtggt aaaactgcag   3000

ttatttttgc accaacctaa taggatttcc tgttggtttt gattctttta aataagcggc   3060

ctacttattt tatgtattac aattctgttg acttaaagta aatgtatgtg ataatgttta   3120

tttttattcc tttcaaataa accagaattt tttctttcat ttgtaactta attatggcct   3180

taactgaatc aacctgaaga taatggagtg aagaaagtga agtgttacaa cccacagcat   3240

catatgtgat accataatga ctgtctacac atagccgatc gtcgtgagtg ctgtcacctg   3300

ctggtttggg ggtagtaatg tgtcgcttta actttcagag taatggagaa agatcctttc   3360

catgcaagtt gtttacctgt acatataggg acgcttgtag agctgaataa agccaatggt   3420

aagactttt                                                           3429


<210>  3070
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  3070


Met Asn Leu Glu Arg Leu Arg Lys Arg Val Arg Gln Tyr Leu Asp Gln 
1               5                   10                  15      


Gln Gln Tyr Gln Ser Ala Leu Phe Trp Ala Asp Lys Val Ala Ser Leu 
            20                  25                  30          


Ser Arg Glu Glu Pro Gln Asp Ile Tyr Trp Leu Ala Gln Cys Leu Tyr 
        35                  40                  45              


Leu Thr Ala Gln Tyr His Arg Ala Ala His Ala Leu Arg Ser Arg Lys 
    50                  55                  60                  


Leu Asp Lys Leu Tyr Glu Ala Cys Arg Tyr Leu Ala Ala Arg Cys His 
65                  70                  75                  80  


Tyr Ala Ala Lys Glu His Gln Gln Ala Leu Asp Val Leu Asp Met Glu 
                85                  90                  95      


Glu Pro Ile Asn Lys Arg Leu Phe Glu Lys Tyr Leu Lys Asp Glu Ser 
            100                 105                 110         


Gly Phe Lys Asp Pro Ser Ser Asp Trp Glu Met Ser Gln Ser Ser Ile 
        115                 120                 125             


Lys Ser Ser Ile Cys Leu Leu Arg Gly Lys Ile Tyr Asp Ala Leu Asp 
    130                 135                 140                 


Asn Arg Thr Leu Ala Thr Tyr Ser Tyr Lys Glu Ala Leu Lys Leu Asp 
145                 150                 155                 160 


Val Tyr Cys Phe Glu Ala Phe Asp Leu Leu Thr Ser His His Met Leu 
                165                 170                 175     


Thr Ala Gln Glu Gly Leu Glu Thr Gln Ala Phe Leu Phe Tyr Val 
            180                 185                 190     

<210>  3071
<211>  2196
<212>  DNA
<213>  Homo sapiens

<400>  3071
gcggccttcg agtccgcggc cttcgagtcc tggggcggcg gcggcggctg caggcacggg     60

cacgggcacg gggcggggtg cttagggtgc aggaggcgcg cgcctagcgg cggagtgtgg    120

cgtgaggccg ggcccgcgcc gccatgaacc tagagcggct gcggaagcgc gtccggcagt    180

acctcgacca gcaacagtat caaagtgctc tattttgggc agataaagta gcttcactct    240

ctcgtgaaga accccaggac atctattggt tggctcagtg tctttacctg acagcacaat    300

atcacagagc cgcccatgca cttcggtcac gaaaactgga caaattgtat gaagcatgtc    360

gttaccttgc agctaggtgc cataagtcgt gagtgatgag cggcacttct gttttccacg    420

tagtatgctg caaaagagca ccagcaggcc cttgatgttc ttgacatgga agagcccatc    480

aataaaagat tatttgaaaa atacttgaag gacgaaagtg gcttcaaaga tccttccagc    540

gactgggaaa tgtcacagtc ttcaataaag agttctatct gtcttctacg cgggaaaatc    600

tatgatgctc tagataaccg aaccctggct acctacagct acaaagaagc tttgaagctt    660

gatgtctact gttttgaagc gttcgatctt ttaacatcac atcacatgct gacagcacaa    720

gaagaaaaag aacttcttga atcactaccc cttagcaagc tgtgtaatga agaacaggaa    780

ttgctgcgtt ttctatttga gaacaaattg aaaaaatata ataagcctag tgaaacggtc    840

atccctgaat ctgtagatgg cttgcaagag aatctggatg tggtagtgtc tttagctgag    900

agacattatt ataactgtga ttttaaaatg tgctacaagc ttacttctgt agtaatggag    960

aaagatcctt tccatgcaag ttgtttacct gtacatatag ggacgcttgt agagctgaat   1020

aaagccaatg aacttttcta tctttctcat aaactggtgg atttatatcc tagtaatcct   1080

gtgtcttggt ttgcagtggg atgttactat ctcatggtcg gtcataaaaa tgaacatgcc   1140

agaagatatc tcagcaaagc cacaacactt gagaaaacct atggacctgc atggatagcc   1200

tatggacatt catttgcggt ggagagtgag cacgaccaag cgatggctgc ttacttcaca   1260

gcagcacagc tgatgaaagg gtgtcatttg cctatgctgt atattggatt agaatatggt   1320

ttgaccaata actcaaaact agctgaaagg ttcttcagcc aagctctgag cattgcaccg   1380

gaagaccctt ttgttatgca tgaggtcggc gtggttgcat ttcagaatgg agaatggaaa   1440

acagccgaaa aatggtttct tgatgctttg gaaaaaatta aagcaattgg gaacgaggta   1500

acagttgaca aatgggaacc tttgttgaac aacttggggc atgtctgcag aaaacttaaa   1560

aagtatgctg aggccttgga ttaccaccgt caggcactgg tgttgattcc tcagaacgca   1620

tccacctact ctgctattgg atatatccac agtctgatgg gcaactttga aaatgctgtg   1680

gactacttcc acacagccct tggtcttagg cgagatgata cattttctgt tacaatgctt   1740

ggtcattgca tcgaaatgta cattggtgat tctgaagctt atattggagc agacattaaa   1800

gacaaattaa aatgttatga ctttgatgtg catacaatga agacactaaa aaacattatt   1860

tcacctccgt gggatttcag ggaatttgaa gtagaaaaac agactgcaga agaaacgggg   1920

cttacgccat tggaaacctc aaggaaaact ccagattcca gaccttcctt ggaagaaacc   1980

tttgaaattg aaatgaatga aagtgacatg atgttagaga catctatgtc agaccacagc   2040

acgtgactcc agtcagtggt cctggtccca ctgtcccagt gtaggaacag agacccgcct   2100

taagagactg gatcgcacac ctttgcaaca gatgtgttct gattctctga acctacaaaa   2160

tagttataca tagtggaata aagaaggtaa accatc                             2196


<210>  3072
<211>  526
<212>  PRT
<213>  Homo sapiens

<400>  3072


Met Glu Glu Pro Ile Asn Lys Arg Leu Phe Glu Lys Tyr Leu Lys Asp 
1               5                   10                  15      


Glu Ser Gly Phe Lys Asp Pro Ser Ser Asp Trp Glu Met Ser Gln Ser 
            20                  25                  30          


Ser Ile Lys Ser Ser Ile Cys Leu Leu Arg Gly Lys Ile Tyr Asp Ala 
        35                  40                  45              


Leu Asp Asn Arg Thr Leu Ala Thr Tyr Ser Tyr Lys Glu Ala Leu Lys 
    50                  55                  60                  


Leu Asp Val Tyr Cys Phe Glu Ala Phe Asp Leu Leu Thr Ser His His 
65                  70                  75                  80  


Met Leu Thr Ala Gln Glu Glu Lys Glu Leu Leu Glu Ser Leu Pro Leu 
                85                  90                  95      


Ser Lys Leu Cys Asn Glu Glu Gln Glu Leu Leu Arg Phe Leu Phe Glu 
            100                 105                 110         


Asn Lys Leu Lys Lys Tyr Asn Lys Pro Ser Glu Thr Val Ile Pro Glu 
        115                 120                 125             


Ser Val Asp Gly Leu Gln Glu Asn Leu Asp Val Val Val Ser Leu Ala 
    130                 135                 140                 


Glu Arg His Tyr Tyr Asn Cys Asp Phe Lys Met Cys Tyr Lys Leu Thr 
145                 150                 155                 160 


Ser Val Val Met Glu Lys Asp Pro Phe His Ala Ser Cys Leu Pro Val 
                165                 170                 175     


His Ile Gly Thr Leu Val Glu Leu Asn Lys Ala Asn Glu Leu Phe Tyr 
            180                 185                 190         


Leu Ser His Lys Leu Val Asp Leu Tyr Pro Ser Asn Pro Val Ser Trp 
        195                 200                 205             


Phe Ala Val Gly Cys Tyr Tyr Leu Met Val Gly His Lys Asn Glu His 
    210                 215                 220                 


Ala Arg Arg Tyr Leu Ser Lys Ala Thr Thr Leu Glu Lys Thr Tyr Gly 
225                 230                 235                 240 


Pro Ala Trp Ile Ala Tyr Gly His Ser Phe Ala Val Glu Ser Glu His 
                245                 250                 255     


Asp Gln Ala Met Ala Ala Tyr Phe Thr Ala Ala Gln Leu Met Lys Gly 
            260                 265                 270         


Cys His Leu Pro Met Leu Tyr Ile Gly Leu Glu Tyr Gly Leu Thr Asn 
        275                 280                 285             


Asn Ser Lys Leu Ala Glu Arg Phe Phe Ser Gln Ala Leu Ser Ile Ala 
    290                 295                 300                 


Pro Glu Asp Pro Phe Val Met His Glu Val Gly Val Val Ala Phe Gln 
305                 310                 315                 320 


Asn Gly Glu Trp Lys Thr Ala Glu Lys Trp Phe Leu Asp Ala Leu Glu 
                325                 330                 335     


Lys Ile Lys Ala Ile Gly Asn Glu Val Thr Val Asp Lys Trp Glu Pro 
            340                 345                 350         


Leu Leu Asn Asn Leu Gly His Val Cys Arg Lys Leu Lys Lys Tyr Ala 
        355                 360                 365             


Glu Ala Leu Asp Tyr His Arg Gln Ala Leu Val Leu Ile Pro Gln Asn 
    370                 375                 380                 


Ala Ser Thr Tyr Ser Ala Ile Gly Tyr Ile His Ser Leu Met Gly Asn 
385                 390                 395                 400 


Phe Glu Asn Ala Val Asp Tyr Phe His Thr Ala Leu Gly Leu Arg Arg 
                405                 410                 415     


Asp Asp Thr Phe Ser Val Thr Met Leu Gly His Cys Ile Glu Met Tyr 
            420                 425                 430         


Ile Gly Asp Ser Glu Ala Tyr Ile Gly Ala Asp Ile Lys Asp Lys Leu 
        435                 440                 445             


Lys Cys Tyr Asp Phe Asp Val His Thr Met Lys Thr Leu Lys Asn Ile 
    450                 455                 460                 


Ile Ser Pro Pro Trp Asp Phe Arg Glu Phe Glu Val Glu Lys Gln Thr 
465                 470                 475                 480 


Ala Glu Glu Thr Gly Leu Thr Pro Leu Glu Thr Ser Arg Lys Thr Pro 
                485                 490                 495     


Asp Ser Arg Pro Ser Leu Glu Glu Thr Phe Glu Ile Glu Met Asn Glu 
            500                 505                 510         


Ser Asp Met Met Leu Glu Thr Ser Met Ser Asp His Ser Thr 
        515                 520                 525     

<210>  3073
<211>  3295
<212>  DNA
<213>  Homo sapiens

<400>  3073
gcggcggcgg cggctgcagg cacgggcacg ggcacggggc ggggtgctta gggtgcagga     60

ggcgcgcgcc tagcggcgga gtgtggcgtg aggccgggcc cgcgccgcca tgaacctaga    120

gcggctgcgg aagcgcgtcc ggcagtacct cgaccagaag aaccccagga catctattgg    180

ttggctcagt gtctttacct gacagcacaa tatcacagag ccgcccatgc acttcggtca    240

cgaaaactgg acaaattgta tgaagcatgt cgttaccttg cagctaggtg ccattatgct    300

gcaaaagagc accagcaggc ccttgatgtt cttgacatgg aagagcccat caataaaaga    360

ttatttgaaa aatacttgaa ggacgaaagt ggcttcaaag atccttccag cgactgggaa    420

atgtcacagt cttcaataaa gagttctatc tgtcttctac gcgggaaaat ctatgatgct    480

ctagataacc gaaccctggc tacctacagc tacaaagaag ctttgaagct tgatgtctac    540

tgttttgaag cgttcgatct tttaacatca catcacatgc tgacagcaca agaaggtttg    600

gaaactcagg cttttttgtt ttatgtttag caaaattaat attgtttgga ttttttgcct    660

ctgaaatctt ctaagtcaac aacaggccac atacaggttt aaatagacct actcactttc    720

ttaatgtctt caaatgtaaa gcacgttgca gaatgcagta ttgtacggtg ccttgtgctg    780

tccgaatcta gggattgtga taggaagagg ccatcttttt gagaagtgat tgagatagta    840

taaaccagga tttcagtatc tcatgcagtg attctcaacc gtgttgctct ttacatcctt    900

gggaagacag agaaacatcc atgtccagtt cccaactcca gagcagatgc tttaaagctc    960

ccaggtgatc ctaatgtacc acaggcactg agaatcagtc caagtatgtt ggcagtggtg   1020

tgaggtgcgt caacaaggga aacagaaaat agagtggttg gattaatggg attctaacat   1080

attttagcct agtgcagtgg ttctcaacca accagagtga ttttgccgcc ccctgccccg   1140

ggaacagttg gcaatgtctg gagatgttgt ttgtcacagc ttaggggcag ggagggaggt   1200

tgagaggttg ctgctggtat ctagtggtta gtggccagag gtcctgctta gcacctgcag   1260

tacacaggct cccctgttcc cagcagagca agatccacgc agtcaggagt gcggaggctg   1320

gtggttctta ggtgacaaga gccacctggg gacctgcctc agccctgaaa gagtagcctc   1380

cacccaccag atgattcccg tcttcaggcc tggagccact gtgtcagctt ctgttgcaca   1440

ttttgatctt atgttctctt ttgagtttga tttacttaga ccaagaactg tagaatcata   1500

tttttagttg ttggcttttt cccctctata aatattatga ggatattctt ttttttctca   1560

ccatttttaa gaaaaagaac ttcttgaatc actacccctt agcaagctgt gtaatgaaga   1620

acaggaattg ctgcgttttc tatttgagaa caaattgaaa aaagtaagta aaaccaaaga   1680

gttagcactt gctttatgta aatatcttat tccataaaat ttggcatcta gtcttatatt   1740

aagttttcaa aattaaaact ttttaaattt agcacatttt taagaataga gcgtttaaga   1800

tacataagat tccaaaaaaa aaaagctttc aaaaatacct ttttcctctg aaagactcct   1860

tatactaaaa gattgaatta ccaagtaaat gtaaatggaa tggtgttgca tggaaatgaa   1920

gatttttttg ttatgcttcc tgaatgttta ctttgagaaa tacgtcccgc tgtggaattc   1980

tgttctaaaa ttgagaaggg aattaaactt actgagagga gtacttataa aacctaaagt   2040

tataagtttt cagaggctct cacatttgtt cttgtaaatg ttttaaccac ttgggccaaa   2100

cacaaattga atccacattt tattttgttt ttgctcattg agtttatgtt tacatttcta   2160

tgtgtttcag tataataagc ctagtgaaac ggtcatccct gaatctgtag atggcttgca   2220

agagaatctg gatgtggtag tgtctttagc tgagagacat tattataact gtgattttaa   2280

aatgtgctac aagcttactt ctgtgtaagt atatccatcc atttttctgt aggaacatgg   2340

agttcactcc atcttaccta ggtgattcac ggacgtgctc tctgaataat cttgaactag   2400

atgataattt aagttatctt taccaattgt agagcactga acagggtgct gtcttaaaag   2460

agcaatttac agacatgaat ttgtgcatat ttgtagattt attacattaa cttgggaggg   2520

atatacatgt tgctcttact gatcttgata atttgcaagt ttgaaaattc cattttggca   2580

cattgttttg taaaatttat tctcaattat gagactcaca ctgtagatac taggtgttta   2640

atatgctgca cgcagtagct aagccatctc ccacatgtat cagttttcca gtgtacctaa   2700

tttaaacttt agctaaatga catatgctat tttttgtaga tcttggttcg gtttaaaatc   2760

cttgaaatta caaaaatttt aattggcaaa tacacataac ctatttatta gtttggtgca   2820

aaagtaattg cagtttttgc tgttgaacgt agtggtaaaa ctgcagttat ttttgcacca   2880

acctaatagg atttcctgtt ggttttgatt cttttaaata agcggcctac ttattttatg   2940

tattacaatt ctgttgactt aaagtaaatg tatgtgataa tgtttatttt tattcctttc   3000

aaataaacca gaattttttc tttcatttgt aacttaatta tggccttaac tgaatcaacc   3060

tgaagataat ggagtgaaga aagtgaagtg ttacaaccca cagcatcata tgtgatacca   3120

taatgactgt ctacacatag ccgatcgtcg tgagtgctgt cacctgctgg tttgggggta   3180

gtaatgtgtc gctttaactt tcagagtaat ggagaaagat cctttccatg caagttgttt   3240

acctgtacat atagggacgc ttgtagagct gaataaagcc aatggtaaga ctttt        3295


<210>  3074
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  3074


Met Glu Glu Pro Ile Asn Lys Arg Leu Phe Glu Lys Tyr Leu Lys Asp 
1               5                   10                  15      


Glu Ser Gly Phe Lys Asp Pro Ser Ser Asp Trp Glu Met Ser Gln Ser 
            20                  25                  30          


Ser Ile Lys Ser Ser Ile Cys Leu Leu Arg Gly Lys Ile Tyr Asp Ala 
        35                  40                  45              


Leu Asp Asn Arg Thr Leu Ala Thr Tyr Ser Tyr Lys Glu Ala Leu Lys 
    50                  55                  60                  


Leu Asp Val Tyr Cys Phe Glu Ala Phe Asp Leu Leu Thr Ser His His 
65                  70                  75                  80  


Met Leu Thr Ala Gln Glu Gly Leu Glu Thr Gln Ala Phe Leu Phe Tyr 
                85                  90                  95      


Val 
    

<210>  3075
<211>  7728
<212>  DNA
<213>  Homo sapiens

<400>  3075
ccctgggcct tcatctgggg ccagcagcgc tgtctccgcc tcgcccagaa gggagcggtc     60

cctgcagctg ggaggggcac agcccgggga gtggaggccc ccgagcgcac ggggcgcctc    120

agtcgggtct gagcctcgtt ctgcacctgg cgcggaggag gtgcccagga aacactgact    180

actcagtgca agttgaagga caatttttgg aggaaagttg cagggctagc taataaaaca    240

tttttgagag gtttagttgt aatttttact gggctgaatt taagtgaata aagatgtgaa    300

gaagcctgtt gtctcaaatc aatactttaa aaattctcgt taactatgtc tgtgttctct    360

gcactacctt tgaatagcag agagcgttta aggcaagaag tgtcttcgag aatcagcagc    420

atcagtttta tctatattgt tgtttatttt ttgttgaaat gcttgctctt tcaggaaatt    480

ggaaagaaag ggaaagaaaa gccatggtaa tgcagagttt tcggaattgg gtgctaactg    540

acgtggccaa atgtttgcag tccatttgga gggctgtgtt tttatttacc atgagtcagt    600

tgaattcagt gttttctgat cactttttct tcggtacgga gacgtagtga ggaatatgac    660

aggcccggtt tccagccaga gacaccggta ttgagcatat ttataactat cccgttggca    720

ttcctcctgc ctcgggctag cagcagtggt cctggcttgt ctccagggga actgaggcag    780

agactgtaga agactgagga ctgaggagca gaacagggtc taaagctagc cgtaggtcac    840

tgtgggtggc cctcattgtc ggctccttca tttttgttag acttggagga ggtgagttct    900

tccccatgtt cagtgaagct tagttaattt atgtgtgtgt gtttttaaac ttgagtgtta    960

ttaaaactgc cactgtgtta tataaggtat ttgagtatag tgttctgtct tctaaatttc   1020

actttgggat tcattaacag ctcgttgaaa gtgttatata aatcacacat gaattgttaa   1080

tgactagctt ttgctgtttc acttgcattt cacttgtatg tttcacgata catttttaca   1140

gtgtatgagt tttaaaaaat taccttcata agttgcatat acaaagatat tacaggaatg   1200

tttgtattgc gacactgaac taaaatttac cctacgtgag atgtaagata gagatgtaac   1260

aaattgttgt cttgagatga agatttatta catagaatta tattaatata ttacatagaa   1320

ttataataat attagataac tgtttaagac tattaaaata acagggcagt taccaccttt   1380

tttttttttt ggtatgcagc aacagtatca aagtgctcta ttttgggcag ataaagtagc   1440

ttcactctct cgtgaagaac cccaggacat ctattggttg gctcagtgtc tttacctgac   1500

agcacaatat cacagagccg cccatgcact tcggtcacga aaactggaca aattgtatga   1560

agcatgtcgt taccttgcag ctaggtgcca ttatgctgca aaagagcacc agcaggccct   1620

tgatgttctt gacatggaag agcccatcaa taaaagatta tttgaaaaat acttgaagga   1680

cgaaagtggc ttcaaagatc cttccagcga ctgggaaatg tcacagtctt caataaagag   1740

ttctatctgt cttctacgcg ggaaaatcta tgatgctcta gataaccgaa ccctggctac   1800

ctacagctac aaagaagctt tgaagcttga tgtctactgt tttgaagcgt tcgatctttt   1860

aacatcacat cacatgctga cagcacaaga aggtttggaa actcaggctt ttttgtttta   1920

tgtttagcaa aattaatatt gtttggattt tttgcctctg aaatcttcta agtcaacaac   1980

aggccacata caggtttaaa tagacctact cactttctta atgtcttcaa atgtaaagca   2040

cgttgcagaa tgcagtattg tacggtgcct tgtgctgtcc gaatctaggg attgtgatag   2100

gaagaggcca tctttttgag aagtgattga gatagtataa accaggattt cagtatctca   2160

tgcagtgatt ctcaaccgtg ttgctcttta catccttggg aagacagaga aacatccatg   2220

tccagttccc aactccagag cagatgcttt aaagctccca ggtgatccta atgtaccaca   2280

ggcactgaga atcagtccaa gtatgttggc agtggtgtga ggtgcgtcaa caagggaaac   2340

agaaaataga gtggttggat taatgggatt ctaacatatt ttagcctagt gcagtggttc   2400

tcaaccaacc agagtgattt tgccgccccc tgccccggga acagttggca atgtctggag   2460

atgttgtttg tcacagctta ggggcaggga gggaggttga gaggttgctg ctggtatcta   2520

gtggttagtg gccagaggtc ctgcttagca cctgcagtac acaggctccc ctgttcccag   2580

cagagcaaga tccacgcagt caggagtgcg gaggctggtg gttcttaggt gacaagagcc   2640

acctggggac ctgcctcagc cctgaaagag tagcctccac ccaccagatg attcccgtct   2700

tcaggcctgg agccactgtg tcagcttctg ttgcacattt tgatcttatg ttctcttttg   2760

agtttgattt acttagacca agaactgtag aatcatattt ttagttgttg gctttttccc   2820

ctctataaat attatgagga tattcttttt tttctcacca tttttaagaa aaagaacttc   2880

ttgaatcact accccttagc aagctgtgta atgaagaaca ggaattgctg cgttttctat   2940

ttgagaacaa attgaaaaaa tataataagc ctagtgaaac ggtcatccct gaatctgtag   3000

atggcttgca agagaatctg gatgtggtag tgtctttagc tgagagacat tattataact   3060

gtgattttaa aatgtgctac aagcttactt ctgtgtaagt atatccatcc atttttctgt   3120

aggaacatgg agttcactcc atcttaccta ggtgattcac ggacgtgctc tctgaataat   3180

cttgaactag atgataattt aagttatctt taccaattgt agagcactga acagggtgct   3240

gtcttaaaag agcaatttac agacatgaat ttgtgcatat ttgtagattt attacattaa   3300

cttgggaggg atatacatgt tgctcttact gatcttgata atttgcaagt ttgaaaattc   3360

cattttggca cattgttttg taaaatttat tctcaattat gagactcaca ctgtagatac   3420

taggtgttta atatgctgca cgcagtagct aagccatctc ccacatgtat cagttttcca   3480

gtgtacctaa tttaaacttt agctaaatga catatgctat tttttgtaga tcttggttcg   3540

gtttaaaatc cttgaaatta caaaaatttt aattggcaaa tacacataac ctatttatta   3600

gtttggtgca aaagtaattg cagtttttgc tgttgaacgt agtggtaaaa ctgcagttat   3660

ttttgcacca acctaatagg atttcctgtt ggttttgatt cttttaaata agcggcctac   3720

ttattttatg tattacaatt ctgttgactt aaagtaaatg tatgtgataa tgtttatttt   3780

tattcctttc aaataaacca gaattttttc tttcatttgt aacttaatta tggccttaac   3840

tgaatcaacc tgaagataat ggagtgaaga aagtgaagtg ttacaaccca cagcatcata   3900

tgtgatacca taatgactgt ctacacatag ccgatcgtcg tgagtgctgt cacctgctgg   3960

tttgggggta gtaatgtgtc gctttaactt tcagagtaat ggagaaagat cctttccatg   4020

caagttgttt acctgtacat atagggacgc ttgtagagct gaataaagcc aatgaacttt   4080

tctatctttc tcataaactg gtggatttat atcctagtaa tcctgtgtct tggtttgcag   4140

tgggatgtta ctatctcatg gtcggtcata aaaatgaaca tgccagaaga tatctcagca   4200

aagccacaac acttgagaaa acctatggac ctgcatggat agcctatgga cattcatttg   4260

cggtggagag tgagcacgac caagcgatgg ctgcttactt cacagcagca cagctgatga   4320

aagggtgtca tttgcctatg ctgtatattg gattagaata tggtttgacc aataactcaa   4380

aactagctga aaggttcttc agccaagctc tgagcattgc accggaagac ccttttgtta   4440

tgcatgaggt cggcgtggtt gcatttcaga atggagaatg gaaaacagcc gaaaaatggt   4500

ttcttgatgc tttggaaaaa attaaagcaa ttgggaacga ggtattcttt gtagtacctg   4560

taaatataca catatacacc cctgagtgtt tactgttaaa tgaggaaaac aacacagaaa   4620

tctcttgcct tcgaagatag taacctgata ttttcataac aagcggctgt taatgtttgc   4680

attgtcagtt aactgtttta ccacatggta agaaatgagt tttttcccta agagggcaag   4740

tgttggcgtt tgcttcttaa atgggctcta gctttgaaac gtgagaggca tcagaataga   4800

ttgggtgatt atttgaagct aggaatagtc attgggtcac ggaaacaatt gggcactgta   4860

gcgtcagatg taatattcct ctagaacttc agagagcttc tttgactgaa gggtaaataa   4920

agtatagcag caggtcccac ttctgaaagg atagggatgg gataggtatt actgaaattc   4980

acaccttttg ttgctgttac tgcatactga gtgtgtattt gggcctttcc attttaaaat   5040

atttgactgc ttctgttgta tgaacgatcc cgtgaattgg tgcttatgag ttaacctaac   5100

aattatcaag gatgtgtata tactgatatt acttaaaagt agtaacagtt ttagatacca   5160

taaacttgca tagtaagaga tttgcatgat gctcttctgt ttcattcgtg cctgttttgt   5220

ttcattctat tctgattttc acttctcagc ttcctgctgt tactgtttgt gcacacctgc   5280

ccacagtttt cttctccctt ggctgttagc tctctctgct gttacagaca cagctttgcc   5340

tccctgccaa gcgatctgcc tgtccccata gacacagctt tgtttacttt ggtctctcat   5400

gtcatctgaa cttataaaca ctatttctgt gtttgcacat gcgtgtatat aaagcaggtg   5460

cctctgtcgc atagtcttgg gtagttctgg ataatccaag tgttttgtta ataggggatt   5520

gccacttgcc accttgtcag ttttctaaga agtgactgcc ttatgcccca gacgggctca   5580

gcagcatcag catcacctag aagcctgcta gaagtgcaga atctcagacc aactgaatca   5640

aaatctgcag ttttagcgtg atgcccaggg gattatcacg cacagaaaag ttttgagaag   5700

cactttccta aaccatactt aagttgagcc tgtattcttt gatgattaag gggcactaaa   5760

tttagagtct tacagaaact taatggtttt aagtatgaaa gcacaacact attgaaatgt   5820

caaaatgctc attaaaaagt tatacgaaga gggggaaaat attgacttta ttagaaactg   5880

cagcaaatgt caaagagaaa cagtcatgcc taagagtcat taaatgattt gtttttcatt   5940

cacatgggct gtgcctccta gaactggtct caatagagtt agagaatctg tggctcaggt   6000

ctgttcattc atttagttga catatattta atgagtgtca gccatgccat aggctctgag   6060

ctaggccttg ggatgcaaag gggaatgagt ttactatttc ctgacctcag atcaactggc   6120

gaatgtaagt acgtaaattg acagtgaaaa tacggtgcaa ttgaggaact aaaggtgccc   6180

acagagaaag gcagttcacc cagaaatgag ccttttgcat acacctcagt cctgaaagtc   6240

atcagacatc agctaggcaa aaattagggc aagggtattc cagtgtttgc aaaaattgga   6300

gctaattcat tatggcttgg attttgagtt cacagagaat gtcaaggagt gggtcaggag   6360

ggttaagtgt ggatcactaa aggcccagaa tgaaagagtt tgtgccttat cctgaggaga   6420

atgggaaaac aaaagggatt taagaaggaa acaacccggt cagactttta tgattggggc   6480

ccagatttga ctctgttaat gaggaaggtg aggactaaat aggttggagt tatgcctagc   6540

aattagaagg aaccagccct ggtgtgcctc atggaagggt cagagggggt gggggtgcca   6600

ttcactgact ggaggggcac tcagaagcag tgaggtcagg ggctgggatg gccagggaga   6660

gatgggtgtg gtgtgtggtg cactaaactt aaagtgcttg taacatttac aagcagaagt   6720

atttagcagg cagatggata gagaggtctg gtgtttgagg gaaagctctg agttgcagat   6780

actcatttga actccagcag ggataggctc ttggataaac ttgtcctaat gataacagag   6840

tcctcaggaa gtctcctagt aggaaagaaa gggagataga taaaacagca gttaccctgg   6900

ccttgtggtg tgctggcggc acacactggg agagagccca gcttgcaagg cgtgaaataa   6960

ttcagtgcaa acaaatcagg ctgaacagtg acatatataa ctcgtgggct tgatgttgct   7020

atgttttagg taacagttga caaatgggaa cctttgttga acaacttggg gcatgtctgc   7080

agaaaactta aaaagtatgc tgaggccttg gattaccacc gtcaggcact ggtgttgatt   7140

cctcagaacg catccaccta ctctgctatt ggatatatcc acagtctgat gggcaacttt   7200

gaaaatgctg tggactactt ccacacagcc cttggtctta ggcgagatga tacattttct   7260

gttacaatgc ttggtcattg catcgaaatg tacattggtg attctgaagc ttatattgga   7320

gcagacatta aagacaaatt aaaatgttat gactttgatg tgcatacaat gaagacacta   7380

aaaaacatta tttcacctcc gtgggatttc agggaatttg aagtagaaaa acagactgca   7440

gaagaaacgg ggcttacgcc attggaaacc tcaaggaaaa ctccagattc cagaccttcc   7500

ttggaagaaa cctttgaaat tgaaatgaat gaaagtgaca tgatgttaga gacatctatg   7560

tcagaccaca gcacgtgact ccagtcagtg gtcctggtcc cactgtccca gtgtaggaac   7620

agagacccgc cttaagagac tggatcgcac acctttgcaa cagatgtgtt ctgattctct   7680

gaacctacaa aatagttata catagtggaa taaagaaggt aaaccatc                7728


<210>  3076
<211>  213
<212>  PRT
<213>  Homo sapiens

<400>  3076


Met Glu Lys Asp Pro Phe His Ala Ser Cys Leu Pro Val His Ile Gly 
1               5                   10                  15      


Thr Leu Val Glu Leu Asn Lys Ala Asn Glu Leu Phe Tyr Leu Ser His 
            20                  25                  30          


Lys Leu Val Asp Leu Tyr Pro Ser Asn Pro Val Ser Trp Phe Ala Val 
        35                  40                  45              


Gly Cys Tyr Tyr Leu Met Val Gly His Lys Asn Glu His Ala Arg Arg 
    50                  55                  60                  


Tyr Leu Ser Lys Ala Thr Thr Leu Glu Lys Thr Tyr Gly Pro Ala Trp 
65                  70                  75                  80  


Ile Ala Tyr Gly His Ser Phe Ala Val Glu Ser Glu His Asp Gln Ala 
                85                  90                  95      


Met Ala Ala Tyr Phe Thr Ala Ala Gln Leu Met Lys Gly Cys His Leu 
            100                 105                 110         


Pro Met Leu Tyr Ile Gly Leu Glu Tyr Gly Leu Thr Asn Asn Ser Lys 
        115                 120                 125             


Leu Ala Glu Arg Phe Phe Ser Gln Ala Leu Ser Ile Ala Pro Glu Asp 
    130                 135                 140                 


Pro Phe Val Met His Glu Val Gly Val Val Ala Phe Gln Asn Gly Glu 
145                 150                 155                 160 


Trp Lys Thr Ala Glu Lys Trp Phe Leu Asp Ala Leu Glu Lys Ile Lys 
                165                 170                 175     


Ala Ile Gly Asn Glu Val Phe Phe Val Val Pro Val Asn Ile His Ile 
            180                 185                 190         


Tyr Thr Pro Glu Cys Leu Leu Leu Asn Glu Glu Asn Asn Thr Glu Ile 
        195                 200                 205             


Ser Cys Leu Arg Arg 
    210             

<210>  3077
<211>  7774
<212>  DNA
<213>  Homo sapiens

<400>  3077
ccctgggcct tcatctgggg ccagcagcgc tgtctccgcc tcgcccagaa gggagcggtc     60

cctgcagctg ggaggggcac agcccgggga gtggaggccc ccgagcgcac ggggcgcctc    120

agtcgggtct gagcctcgtt ctgcacctgg cgcggaggag gtgcccagga aacactgact    180

actcagtgca agttgaagga caatttttgg aggaaagttg cagggctagc taataaaaca    240

tttttgagag gtttagttgt aatttttact gggctgaatt taagtgaata aagatgtgaa    300

gaagcctgtt gtctcaaatc aatactttaa aaattctcgt taactatgtc tgtgttctct    360

gcactacctt tgaatagcag agagcgttta aggcaagaag tgtcttcgag aatcagcagc    420

atcagtttta tctatattgt tgtttatttt ttgttgaaat gcttgctctt tcaggaaatt    480

ggaaagaaag ggaaagaaaa gccatggtaa tgcagagttt tcggaattgg gtgctaactg    540

acgtggccaa atgtttgcag tccatttgga gggctgtgtt tttatttacc atgagtcagt    600

tgaattcagt gttttctgat cactttttct tcggtacgga gacgtagtga ggaatatgac    660

aggcccggtt tccagccaga gacaccggta ttgagcatat ttataactat cccgttggca    720

ttcctcctgc ctcgggctag cagcagtggt cctggcttgt ctccagggga actgaggcag    780

agactgtaga agactgagga ctgaggagca gaacagggtc taaagctagc cgtaggtcac    840

tgtgggtggc cctcattgtc ggctccttca tttttgttag acttggagga ggtgagttct    900

tccccatgtt cagtgaagct tagttaattt atgtgtgtgt gtttttaaac ttgagtgtta    960

ttaaaactgc cactgtgtta tataaggtat ttgagtatag tgttctgtct tctaaatttc   1020

actttgggat tcattaacag ctcgttgaaa gtgttatata aatcacacat gaattgttaa   1080

tgactagctt ttgctgtttc acttgcattt cacttgtatg tttcacgata catttttaca   1140

gtgtatgagt tttaaaaaat taccttcata agttgcatat acaaagatat tacaggaatg   1200

tttgtattgc gacactgaac taaaatttac cctacgtgag atgtaagata gagatgtaac   1260

aaattgttgt cttgagatga agatttatta catagaatta tattaatata ttacatagaa   1320

ttataataat attagataac tgtttaagac tattaaaata acagggcagt taccaccttt   1380

tttttttttt ggtatgcagc aacagtatca aagtgctcta ttttgggcag ataaagtagc   1440

ttcactctct cgtgaagaac cccaggacat ctattggttg gctcagtgtc tttacctgac   1500

agcacaatat cacagagccg cccatgcact tcggtcacga aaactggaca aattgtatga   1560

agcatgtcgt taccttgcag ctaggtgcca ttatgctgca aaagagcacc agcaggccct   1620

tgatgttctt gacatggaag agcccatcaa taaaagatta tttgaaaaat acttgaagga   1680

cgaaagtggc ttcaaagatc cttccagcga ctgggaaatg tcacagtctt caataaagag   1740

ttctatctgt cttctacgcg ggaaaatcta tgatgctcta gataaccgaa ccctggctac   1800

ctacagctac aaagaagctt tgaagcttga tgtctactgt tttgaagcgt tcgatctttt   1860

aacatcacat cacatgctga cagcacaaga aggtttggaa actcaggctt ttttgtttta   1920

tgtttagcaa aattaatatt gtttggattt tttgcctctg aaatcttcta agtcaacaac   1980

aggccacata caggtttaaa tagacctact cactttctta atgtcttcaa atgtaaagca   2040

cgttgcagaa tgcagtattg tacggtgcct tgtgctgtcc gaatctaggg attgtgatag   2100

gaagaggcca tctttttgag aagtgattga gatagtataa accaggattt cagtatctca   2160

tgcagtgatt ctcaaccgtg ttgctcttta catccttggg aagacagaga aacatccatg   2220

tccagttccc aactccagag cagatgcttt aaagctccca ggtgatccta atgtaccaca   2280

ggcactgaga atcagtccaa gtatgttggc agtggtgtga ggtgcgtcaa caagggaaac   2340

agaaaataga gtggttggat taatgggatt ctaacatatt ttagcctagt gcagtggttc   2400

tcaaccaacc agagtgattt tgccgccccc tgccccggga acagttggca atgtctggag   2460

atgttgtttg tcacagctta ggggcaggga gggaggttga gaggttgctg ctggtatcta   2520

gtggttagtg gccagaggtc ctgcttagca cctgcagtac acaggctccc ctgttcccag   2580

cagagcaaga tccacgcagt caggagtgcg gaggctggtg gttcttaggt gacaagagcc   2640

acctggggac ctgcctcagc cctgaaagag tagcctccac ccaccagatg attcccgtct   2700

tcaggcctgg agccactgtg tcagcttctg ttgcacattt tgatcttatg ttctcttttg   2760

agtttgattt acttagacca agaactgtag aatcatattt ttagttgttg gctttttccc   2820

ctctataaat attatgagga tattcttttt tttctcacca tttttaagaa aaagaacttc   2880

ttgaatcact accccttagc aagctgtgta atgaagaaca ggaattgctg cgttttctat   2940

ttgagaacaa attgaaaaaa tataataagc ctagtgaaac ggtcatccct gaatctgtag   3000

atggcttgca agagaatctg gatgtggtag tgtctttagc tgagagacat tattataact   3060

gtgattttaa aatgtgctac aagcttactt ctgtgtaagt atatccatcc atttttctgt   3120

aggaacatgg agttcactcc atcttaccta ggtgattcac ggacgtgctc tctgaataat   3180

cttgaactag atgataattt aagttatctt taccaattgt agagcactga acagggtgct   3240

gtcttaaaag agcaatttac agacatgaat ttgtgcatat ttgtagattt attacattaa   3300

cttgggaggg atatacatgt tgctcttact gatcttgata atttgcaagt ttgaaaattc   3360

cattttggca cattgttttg taaaatttat tctcaattat gagactcaca ctgtagatac   3420

taggtgttta atatgctgca cgcagtagct aagccatctc ccacatgtat cagttttcca   3480

gtgtacctaa tttaaacttt agctaaatga catatgctat tttttgtaga tcttggttcg   3540

gtttaaaatc cttgaaatta caaaaatttt aattggcaaa tacacataac ctatttatta   3600

gtttggtgca aaagtaattg cagtttttgc tgttgaacgt agtggtaaaa ctgcagttat   3660

ttttgcacca acctaatagg atttcctgtt ggttttgatt cttttaaata agcggcctac   3720

ttattttatg tattacaatt ctgttgactt aaagtaaatg tatgtgataa tgtttatttt   3780

tattcctttc aaataaacca gaattttttc tttcatttgt aacttaatta tggccttaac   3840

tgaatcaacc tgaagataat ggagtgaaga aagtgaagtg ttacaaccca cagcatcata   3900

tgtgatacca taatgactgt ctacacatag ccgatcgtcg tgagtgctgt cacctgctgg   3960

tttgggggta gtaatgtgtc gctttaactt tcagagtaat ggagaaagat cctttccatg   4020

caagttgttt acctgtacat atagggacgc ttgtagagct gaataaagcc aatgaacttt   4080

tctatctttc tcataaactg gtggatttat atcctagtaa tcctgtgtct tggtttgcag   4140

tgggatgtta ctatctcatg gtcggtcata aaaatgaaca tgccagaaga tatctcagca   4200

aagccacaac acttgagaaa acctatggac ctgcatggat agcctatgga cattcatttg   4260

cggtggagag tgagcacgac caagcgatgg ctgcttactt cacagcagca cagctgatga   4320

aagggtgtca tttgcctatg ctgtatattg gattagaata tggtttgacc aataactcaa   4380

aactagctga aaggttcttc agccaagctc tgagcattgc accggaagac ccttttgtta   4440

tgcatgaggt cggcgtggtt gcatttcaga atggagaatg gaaaacagcc gaaaaatggt   4500

ttcttgatgc tttggaaaaa attaaagcaa ttgggaacga ggtattcttt gtagtacctg   4560

taaatataca catatacacc cctgagtgtt tactgttaaa tgaggaaaac aacacagaaa   4620

tctcttgcct tcgaagatag taacctgata ttttcataac aagcggctgt taatgtttgc   4680

attgtcagtt aactgtttta ccacatggta agaaatgagt tttttcccta agagggcaag   4740

tgttggcgtt tgcttcttaa atgggctcta gctttgaaac gtgagaggca tcagaataga   4800

ttgggtgatt atttgaagct aggaatagtc attgggtcac ggaaacaatt gggcactgta   4860

gcgtcagatg taatattcct ctagaacttc agagagcttc tttgactgaa gggtaaataa   4920

agtatagcag caggtcccac ttctgaaagg atagggatgg gataggtatt actgaaattc   4980

acaccttttg ttgctgttac tgcatactga gtgtgtattt gggcctttcc attttaaaat   5040

atttgactgc ttctgttgta tgaacgatcc cgtgaattgg tgcttatgag ttaacctaac   5100

aattatcaag gatgtgtata tactgatatt acttaaaagt agtaacagtt ttagatacca   5160

taaacttgca tagtaagaga tttgcatgat gctcttctgt ttcattcgtg cctgttttgt   5220

ttcattctat tctgattttc acttctcagc ttcctgctgt tactgtttgt gcacacctgc   5280

ccacagtttt cttctccctt ggctgttagc tctctctgct gttacagaca cagctttgcc   5340

tccctgccaa gcgatctgcc tgtccccata gacacagctt tgtttacttt ggtctctcat   5400

gtcatctgaa cttataaaca ctatttctgt gtttgcacat gcgtgtatat aaagcaggtg   5460

cctctgtcgc atagtcttgg gtagttctgg ataatccaag tgttttgtta ataggggatt   5520

gccacttgcc accttgtcag ttttctaaga agtgactgcc ttatgcccca gacgggctca   5580

gcagcatcag catcacctag aagcctgcta gaagtgcaga atctcagacc aactgaatca   5640

aaatctgcag ttttagcgtg atgcccaggg gattatcacg cacagaaaag ttttgagaag   5700

cactttccta aaccatactt aagttgagcc tgtattcttt gatgattaag gggcactaaa   5760

tttagagtct tacagaaact taatggtttt aagtatgaaa gcacaacact attgaaatgt   5820

caaaatgctc attaaaaagt tatacgaaga gggggaaaat attgacttta ttagaaactg   5880

cagcaaatgt caaagagaaa cagtcatgcc taagagtcat taaatgattt gtttttcatt   5940

cacatgggct gtgcctccta gaactggtct caatagagtt agagaatctg tggctcaggt   6000

ctgttcattc atttagttga catatattta atgagtgtca gccatgccat aggctctgag   6060

ctaggccttg ggatgcaaag gggaatgagt ttactatttc ctgacctcag atcaactggc   6120

gaatgtaagt acgtaaattg acagtgaaaa tacggtgcaa ttgaggaact aaaggtgccc   6180

acagagaaag gcagttcacc cagaaatgag ccttttgcat acacctcagt cctgaaagtc   6240

atcagacatc agctaggcaa aaattagggc aagggtattc cagtgtttgc aaaaattgga   6300

gctaattcat tatggcttgg attttgagtt cacagagaat gtcaaggagt gggtcaggag   6360

ggttaagtgt ggatcactaa aggcccagaa tgaaagagtt tgtgccttat cctgaggaga   6420

atgggaaaac aaaagggatt taagaaggaa acaacccggt cagactttta tgattggggc   6480

ccagatttga ctctgttaat gaggaaggtg aggactaaat aggttggagt tatgcctagc   6540

aattagaagg aaccagccct ggtgtgcctc atggaagggt cagagggggt gggggtgcca   6600

ttcactgact ggaggggcac tcagaagcag tgaggtcagg ggctgggatg gccagggaga   6660

gatgggtgtg gtgtgtggtg cactaaactt aaagtgcttg taacatttac aagcagaagt   6720

atttagcagg cagatggata gagaggtctg gtgtttgagg gaaagctctg agttgcagat   6780

actcatttga actccagcag ggataggctc ttggataaac ttgtcctaat gataacagag   6840

tcctcaggaa gtctcctagt aggaaagaaa gggagataga taaaacagca gttaccctgg   6900

ccttgtggtg tgctggcggc acacactggg agagagccca gcttgcaagg cgtgaaataa   6960

ttcagtgcaa acaaatcagg ctgaacagtg acatatataa ctcgtgggct tgatgttgct   7020

atgttttagg taacagttga caaatgggaa cctttgttga acaacttggg gcatgtctgc   7080

agaaaactta aaaagtatgc tgaggccttg gattaccacc gtcaggcact ggtgttgatt   7140

cctcagaacg catccaccta ctctgctatt ggatatatcc acagtctgat gggcaacttt   7200

gaaaatgctg tggactactt ccacacagcc cttggtctta ggcgagatga tacattttct   7260

gttacaatgc ttggtcattg catcgaaatg tacattggtg attctgaagc ttatattgga   7320

gcagacatta aagacaaatt aaaatgttat gactttgatg tgcatacaat gaagacacta   7380

aaaaacatta tttcacctcc gtgggatttc agggaatttg aagtagaaaa acagactgca   7440

gaagaaacgg ggcttacgcc attggaaacc tcaaggaaaa ctccagattc cagaccttcc   7500

ttggaagaaa cctttgaaat tgaaatgaat gaaagtgaca tgatgttaga gacatctatg   7560

tcagaccaca gcacgtgact ccagtcagtg gtcctggtcc cactgtccca gtgtaggaac   7620

agagacccgc cttaagagac tggatcgcac acctttgcaa cagatgtgtt ctgattctct   7680

gaacctacaa aatagttata catagtggaa taaagaaggt aaaccatctg ttatgtcttt   7740

ttttttcttt tccaataaac ttttattttg gact                               7774


<210>  3078
<211>  213
<212>  PRT
<213>  Homo sapiens

<400>  3078


Met Glu Lys Asp Pro Phe His Ala Ser Cys Leu Pro Val His Ile Gly 
1               5                   10                  15      


Thr Leu Val Glu Leu Asn Lys Ala Asn Glu Leu Phe Tyr Leu Ser His 
            20                  25                  30          


Lys Leu Val Asp Leu Tyr Pro Ser Asn Pro Val Ser Trp Phe Ala Val 
        35                  40                  45              


Gly Cys Tyr Tyr Leu Met Val Gly His Lys Asn Glu His Ala Arg Arg 
    50                  55                  60                  


Tyr Leu Ser Lys Ala Thr Thr Leu Glu Lys Thr Tyr Gly Pro Ala Trp 
65                  70                  75                  80  


Ile Ala Tyr Gly His Ser Phe Ala Val Glu Ser Glu His Asp Gln Ala 
                85                  90                  95      


Met Ala Ala Tyr Phe Thr Ala Ala Gln Leu Met Lys Gly Cys His Leu 
            100                 105                 110         


Pro Met Leu Tyr Ile Gly Leu Glu Tyr Gly Leu Thr Asn Asn Ser Lys 
        115                 120                 125             


Leu Ala Glu Arg Phe Phe Ser Gln Ala Leu Ser Ile Ala Pro Glu Asp 
    130                 135                 140                 


Pro Phe Val Met His Glu Val Gly Val Val Ala Phe Gln Asn Gly Glu 
145                 150                 155                 160 


Trp Lys Thr Ala Glu Lys Trp Phe Leu Asp Ala Leu Glu Lys Ile Lys 
                165                 170                 175     


Ala Ile Gly Asn Glu Val Phe Phe Val Val Pro Val Asn Ile His Ile 
            180                 185                 190         


Tyr Thr Pro Glu Cys Leu Leu Leu Asn Glu Glu Asn Asn Thr Glu Ile 
        195                 200                 205             


Ser Cys Leu Arg Arg 
    210             

<210>  3079
<211>  451
<212>  DNA
<213>  Homo sapiens

<400>  3079
agattatatt gccaccatgg aagaggagga gctggaagga gattctgaag ccttgggaca     60

aagctggtgc tgcggcagtc agagcagaga gacagaatga tgccactgat tgctgtgctt    120

ttggagactg ttctacttct gaatttccaa ttcagtgaaa taatgcctgt cctcatttat    180

tagcctttta gagctctgct gctgtcctgt ccataaggtt atttgttggt aaaatattaa    240

actacaggaa acataacagc ctcagaaaag catgactcaa catgagcctg ggacaactca    300

gggtctctct actgtgcaca gcatttgttc tgctttcaag gctccccaca gcatctgaag    360

ctttacatcc ctggaggcaa ctgcccatat gtttaccttt attaccaact gcagtttcca    420

ggcatctgct aaattacaat tttgagtgct t                                   451


<210>  3080
<211>  55
<212>  PRT
<213>  Homo sapiens

<400>  3080


Met Ser Leu Gly Gln Leu Arg Val Ser Leu Leu Cys Thr Ala Phe Val 
1               5                   10                  15      


Leu Leu Ser Arg Leu Pro Thr Ala Ser Glu Ala Leu His Pro Trp Arg 
            20                  25                  30          


Gln Leu Pro Ile Cys Leu Pro Leu Leu Pro Thr Ala Val Ser Arg His 
        35                  40                  45              


Leu Leu Asn Tyr Asn Phe Glu 
    50                  55  

<210>  3081
<211>  547
<212>  DNA
<213>  Homo sapiens

<400>  3081
ttctgcttta gagcatgtaa aaaattagag ataacaaaat gacacttaat agacgctgga     60

catgtagagg gaaatgtagc ttttaaagac atttttcttc tattcctggc aaaagtaagc    120

gagggaaagg tgaatgtagc aggtacaaat cacacaggca gaaaatacag aggaaagacc    180

taaagcctaa ctcaattcta tggattttaa ttatggaaat ctggccaagt cactcccctc    240

cttgcaggga ttgttattac tttattatga aaaaattgaa acagttgtct tctctactgc    300

acagggttgt ggcaaaaaca aaatggcatt gtgaatgtaa aagttcatta aaaactctaa    360

aatgtgatag cataatgtaa accacttttt tttttttttt ttttccaaaa cggagtctcg    420

ctctgtcgcc caggctggag tgcagtggcg cgatttcggc tcactgcaag ctccgcctcc    480

caggaggatg gcttgagccc aggagttcaa gaccagctgg gtcaacaaag taagacctcg    540

tctcaac                                                              547


<210>  3082
<211>  55
<212>  PRT
<213>  Homo sapiens

<400>  3082


Met Glu Ile Trp Pro Ser His Ser Pro Pro Cys Arg Asp Cys Tyr Tyr 
1               5                   10                  15      


Phe Ile Met Lys Lys Leu Lys Gln Leu Ser Ser Leu Leu His Arg Val 
            20                  25                  30          


Val Ala Lys Thr Lys Trp His Cys Glu Cys Lys Ser Ser Leu Lys Thr 
        35                  40                  45              


Leu Lys Cys Asp Ser Ile Met 
    50                  55  

<210>  3083
<211>  510
<212>  DNA
<213>  Homo sapiens

<400>  3083
gtaggcccag cttccacaaa aggagcagtt ttttggtgca gaggtagaga agcctctccc     60

tgtggccact accaccacca acccacagca ggttttgcca ggccaccacc aatgttcact    120

taaagccgaa aagctcttcg gtcatctgaa gaggtgcaca gactcctcgc aatgcaaggc    180

cactgccagg gaatgctgga ggggtgatgc tagcaattga agattgtctc tcctaccctc    240

ttcaatgcct ctttcagcaa tatgaagtta aaaccagatt agtgttgggt ctgaagttcc    300

aaatcctgct gcctctgtga agtctttctg ctcatgctag aagcaatatc acctcttcta    360

gaattgtaaa gtgccatttt ccataccact tataatatac tgtcttgtag atgtttttct    420

gtcgtctgta tttcatccct ctaatagatg ataaatttct agaggatgcc tcccacagaa    480

aaagtgctca ataaatatct gtcattggtg                                     510


<210>  3084
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  3084


Met Leu Ala Ile Glu Asp Cys Leu Ser Tyr Pro Leu Gln Cys Leu Phe 
1               5                   10                  15      


Gln Gln Tyr Glu Val Lys Thr Arg Leu Val Leu Gly Leu Lys Phe Gln 
            20                  25                  30          


Ile Leu Leu Pro Leu 
        35          

<210>  3085
<211>  3664
<212>  DNA
<213>  Homo sapiens

<400>  3085
ctgttgtcat gggggaggtg gtggcgcttg gtggccactg gcggccgagg tagaggcagt     60

ggcgcttgag ttggtcgggg gcagcggcag atttgaggct taagcaactt cttccgggga    120

agagtgccag tgcagccact gttacaattc aagatcttga tctatatcca tagattggaa    180

tattggtggg ccagcaatcc tcagacgcct cacttaggac aagctgtaaa aattaaaatg    240

aacaaattac ggcaaagttt taggagaaag aaggatgttt atgttccaga ggccagtcgt    300

ccacatcagt ggcagacaga tgaagaaggc gttcgcaccg gaaaatgtag cttcccggtt    360

aagtaccttg gccatgtaga agttgatgaa tcaagaggaa tgcacatctg tgaagatgct    420

gtaaaaagat tgaaagctga aaggaagttc ttcaaaggct tctttggaaa aactggaaag    480

aaagcagtta aagcagttct gtgggtctca gcagatggac tcagagttgt ggatgaaaaa    540

actaaggacc tcatagttga ccagacgata gagaaagttt ctttctgtgc cccagacagg    600

aactttgata gagccttttc ttacatatgc cgtgatggca ccactcgtcg ctggatctgt    660

cactgcttca tggctgtcaa ggacacaggt gaaaggttga gccatgcagt aggctgtgct    720

tttgcagcct gtttagagcg caagcagaag cgggagaagg aatgtggagt gactgctact    780

tttgatgcta gtcggaccac ttttacaaga gaaggatcat tccgtgtcac aacagccact    840

gaacaagcag aaagagagga gatcatgaaa caaatgcaag atgccaagaa agctgaaaca    900

gataagatag tcgttggttc atcagttgcc cctggcaaca ctgccccatc cccatcctct    960

cccacctctc ctacttctga tgccacgacc tctctggaga tgaacaatcc tcatgccatc   1020

ccacgccggc atgctccaat tgaacagctt gctcgccaag gctctttccg aggttttcct   1080

gctcttagcc agaagatgtc accctttaaa cgccaactat ccctacgcat caatgagttg   1140

ccttccacta tgcagaggaa gactgatttc cccattaaaa atgcagtgcc agaagtagaa   1200

ggggaggcag agagcatcag ctccctgtgc tcacagatca ccaatgcctt cagcacacct   1260

gaggacccct tctcatctgc tccgatgacc aaaccagtga cagtggtggc accacaatct   1320

cctaccttcc aagctaatgg cactgactca gccttccatg tgcttgctaa gccagcccat   1380

actgctctag cacccgtagc aatgcctgtg cgtgaaacca acccttgggc ccatgcccct   1440

gatgctgcta acaaggaaat tgcagccaca tgttcgggga ccgagtgggg tcaatcttct   1500

ggtgctgcct ctccaggtct cttccaggcc ggtcatagac gtactccctc tgaggccgac   1560

cgatggttag aagaggtgtc taagagcgtc cgggctcagc agccccaggc ctcagctgct   1620

cctctgcagc cagttctcca gcctcctcca cccactgcca tctcccagcc agcatcacct   1680

ttccaaggga atgcattcct cacctctcag cctgtgccag tgggtgtggt cccagccctg   1740

caaccagcct ttgtccctgc ccagtcctat cctgtggcca atggaatgcc ctatccagcc   1800

cctaatgtgc ctgtggtggg catcactccc tcccagatgg tggccaacgt atttggcact   1860

gcaggccacc ctcaggctgc ccatccccat cagtcaccca gcctggtcag gcagcagaca   1920

ttccctcact acgaggcaag cagtgctacc accagtccct tctttaagcc tcctgctcag   1980

cacctcaacg gttctgcagc tttcaatggt gtagatgatg gcaggttggc ctcagcagac   2040

aggcatacag aggttcctac aggcacctgc ccagtggatc cttttgaagc ccagtgggct   2100

gcattagaaa ataagtccaa gcagcgtact aatccctccc ctaccaaccc tttctccagt   2160

gacttacaga agacgtttga aattgaactt taagcaatca ttatggctat gtatcttgtc   2220

cataccagac agggagcagg gggtagcggt caaaggagca aaacagactt tgtctcctga   2280

ttagtactct tttcactaat cccaaaggtc ccaaggaaca agtccaggcc cagagtactg   2340

tgaggggtga ttttgaaaga catgggaaaa agcattccta gagaaaagct gccttgcaat   2400

taggctaaag aagtcaagga aatgttgctt tctgtactcc ctcttccctt acccccttac   2460

aaatctctgg caacagagag gcaaagtatc tgaacaagaa tctatattcc aagcacattt   2520

actgaaatgt aaaacacaac aggaagcaaa gcaatctccc tttgtttttc aggccattca   2580

cctgcctcct gtcagtagtg gcctgtatta gagatcaaga agagtggttt gtgctcaggc   2640

tggggaacag agaggcacgc tatgctgcca gaattcccag gagggcatat cagcaactgc   2700

ccagcagagc tatattttgg gggagaagtt gagcttccat tttgagtaac agaataaata   2760

ttatatatat caaaagccaa aatctttatt tttatgcatt tagaatattt taaatagttc   2820

tcagatatta agaagttgta tgagttgtaa gtaatcttgc caaaggtaaa ggggctagtt   2880

gtaagaaatt gtacataaga ttgatttatc attgatgcct actgaaataa aaagaggaaa   2940

ggctggaagc tgcagacagg atccctagct tgttttctgt cagtcattca ttgtaagtag   3000

cacattgcaa caacaatcat gcttatgacc aatacagtca ctaggttgta gtttttttta   3060

aataaaggaa aagcagtatt gtcctggttt taaacctatg atggaattct aatgtcatta   3120

ttttaatgga atcaatcgaa atatgctcta tagagaatat atcttttata tattgctgca   3180

gtttccttat gttaatcctt taacactaag gtaacatgac ataatcatac catagaaggg   3240

aacacaggtt accatattgg tttgtaatat gggtcttggt gggttttgtt ttatccttta   3300

aattttgttc ccatgagttt tgtggggatg gggattctgg ttttattagc tttgtgtgtg   3360

tcctcttccc ccaaaccccc ttttggtgag aacatcccct tgacagttgc agcctcttga   3420

cctcggataa caataagaga gctcatctca tttttacttt tgaacgttgg ccttacaatc   3480

aaatgtaagt tatatatatt tgtactgatg aaaatttata atctgcttta acaaaaataa   3540

atgttcatgg tagaagcttt tgcccatgaa gggctgttct ttcccctttc ctttattagt   3600

aaatgaattt atttttcgtt cttttggtct tactctccat tctactgctg ctgtaaatcc   3660

ctag                                                                3664


<210>  3086
<211>  651
<212>  PRT
<213>  Homo sapiens

<400>  3086


Met Asn Lys Leu Arg Gln Ser Phe Arg Arg Lys Lys Asp Val Tyr Val 
1               5                   10                  15      


Pro Glu Ala Ser Arg Pro His Gln Trp Gln Thr Asp Glu Glu Gly Val 
            20                  25                  30          


Arg Thr Gly Lys Cys Ser Phe Pro Val Lys Tyr Leu Gly His Val Glu 
        35                  40                  45              


Val Asp Glu Ser Arg Gly Met His Ile Cys Glu Asp Ala Val Lys Arg 
    50                  55                  60                  


Leu Lys Ala Glu Arg Lys Phe Phe Lys Gly Phe Phe Gly Lys Thr Gly 
65                  70                  75                  80  


Lys Lys Ala Val Lys Ala Val Leu Trp Val Ser Ala Asp Gly Leu Arg 
                85                  90                  95      


Val Val Asp Glu Lys Thr Lys Asp Leu Ile Val Asp Gln Thr Ile Glu 
            100                 105                 110         


Lys Val Ser Phe Cys Ala Pro Asp Arg Asn Phe Asp Arg Ala Phe Ser 
        115                 120                 125             


Tyr Ile Cys Arg Asp Gly Thr Thr Arg Arg Trp Ile Cys His Cys Phe 
    130                 135                 140                 


Met Ala Val Lys Asp Thr Gly Glu Arg Leu Ser His Ala Val Gly Cys 
145                 150                 155                 160 


Ala Phe Ala Ala Cys Leu Glu Arg Lys Gln Lys Arg Glu Lys Glu Cys 
                165                 170                 175     


Gly Val Thr Ala Thr Phe Asp Ala Ser Arg Thr Thr Phe Thr Arg Glu 
            180                 185                 190         


Gly Ser Phe Arg Val Thr Thr Ala Thr Glu Gln Ala Glu Arg Glu Glu 
        195                 200                 205             


Ile Met Lys Gln Met Gln Asp Ala Lys Lys Ala Glu Thr Asp Lys Ile 
    210                 215                 220                 


Val Val Gly Ser Ser Val Ala Pro Gly Asn Thr Ala Pro Ser Pro Ser 
225                 230                 235                 240 


Ser Pro Thr Ser Pro Thr Ser Asp Ala Thr Thr Ser Leu Glu Met Asn 
                245                 250                 255     


Asn Pro His Ala Ile Pro Arg Arg His Ala Pro Ile Glu Gln Leu Ala 
            260                 265                 270         


Arg Gln Gly Ser Phe Arg Gly Phe Pro Ala Leu Ser Gln Lys Met Ser 
        275                 280                 285             


Pro Phe Lys Arg Gln Leu Ser Leu Arg Ile Asn Glu Leu Pro Ser Thr 
    290                 295                 300                 


Met Gln Arg Lys Thr Asp Phe Pro Ile Lys Asn Ala Val Pro Glu Val 
305                 310                 315                 320 


Glu Gly Glu Ala Glu Ser Ile Ser Ser Leu Cys Ser Gln Ile Thr Asn 
                325                 330                 335     


Ala Phe Ser Thr Pro Glu Asp Pro Phe Ser Ser Ala Pro Met Thr Lys 
            340                 345                 350         


Pro Val Thr Val Val Ala Pro Gln Ser Pro Thr Phe Gln Ala Asn Gly 
        355                 360                 365             


Thr Asp Ser Ala Phe His Val Leu Ala Lys Pro Ala His Thr Ala Leu 
    370                 375                 380                 


Ala Pro Val Ala Met Pro Val Arg Glu Thr Asn Pro Trp Ala His Ala 
385                 390                 395                 400 


Pro Asp Ala Ala Asn Lys Glu Ile Ala Ala Thr Cys Ser Gly Thr Glu 
                405                 410                 415     


Trp Gly Gln Ser Ser Gly Ala Ala Ser Pro Gly Leu Phe Gln Ala Gly 
            420                 425                 430         


His Arg Arg Thr Pro Ser Glu Ala Asp Arg Trp Leu Glu Glu Val Ser 
        435                 440                 445             


Lys Ser Val Arg Ala Gln Gln Pro Gln Ala Ser Ala Ala Pro Leu Gln 
    450                 455                 460                 


Pro Val Leu Gln Pro Pro Pro Pro Thr Ala Ile Ser Gln Pro Ala Ser 
465                 470                 475                 480 


Pro Phe Gln Gly Asn Ala Phe Leu Thr Ser Gln Pro Val Pro Val Gly 
                485                 490                 495     


Val Val Pro Ala Leu Gln Pro Ala Phe Val Pro Ala Gln Ser Tyr Pro 
            500                 505                 510         


Val Ala Asn Gly Met Pro Tyr Pro Ala Pro Asn Val Pro Val Val Gly 
        515                 520                 525             


Ile Thr Pro Ser Gln Met Val Ala Asn Val Phe Gly Thr Ala Gly His 
    530                 535                 540                 


Pro Gln Ala Ala His Pro His Gln Ser Pro Ser Leu Val Arg Gln Gln 
545                 550                 555                 560 


Thr Phe Pro His Tyr Glu Ala Ser Ser Ala Thr Thr Ser Pro Phe Phe 
                565                 570                 575     


Lys Pro Pro Ala Gln His Leu Asn Gly Ser Ala Ala Phe Asn Gly Val 
            580                 585                 590         


Asp Asp Gly Arg Leu Ala Ser Ala Asp Arg His Thr Glu Val Pro Thr 
        595                 600                 605             


Gly Thr Cys Pro Val Asp Pro Phe Glu Ala Gln Trp Ala Ala Leu Glu 
    610                 615                 620                 


Asn Lys Ser Lys Gln Arg Thr Asn Pro Ser Pro Thr Asn Pro Phe Ser 
625                 630                 635                 640 


Ser Asp Leu Gln Lys Thr Phe Glu Ile Glu Leu 
                645                 650     

<210>  3087
<211>  3771
<212>  DNA
<213>  Homo sapiens

<400>  3087
agaagtatga aagagggtgg gcctgttgtc atgggggagg tggtggcgct tggtggccac     60

tggcggccga ggtagaggca gtggcgcttg agttggtcgg gggcagcggc agatttgagg    120

cttaagcaac ttcttccggg gaagagtgcc agtgcagcca ctgttacaat tcaagatctt    180

gatctatatc catagattgg aatattggtg ggccagcaat cctcagacgc ctcacttagg    240

acaaatgagg aaactgaggc ttggtgaagt tacgaaactt gtccaaaatc acacaacttg    300

taaagggcac agccaagatt cagagccagg ctgtaaaaat taaaatgaac aaattacggc    360

aaagttttag gagaaagaag gatgtttatg ttccagaggc cagtcgtcca catcagtggc    420

agacagatga agaaggcgtt cgcaccggaa aatgtagctt cccggttaag taccttggcc    480

atgtagaagt tgatgaatca agaggaatgc acatctgtga agatgctgta aaaagattga    540

aagctgaaag gaagttcttc aaaggcttct ttggaaaaac tggaaagaaa gcagttaaag    600

cagttctgtg ggtctcagca gatggactca gagttgtgga tgaaaaaact aaggacctca    660

tagttgacca gacgatagag aaagtttctt tctgtgcccc agacaggaac tttgatagag    720

ccttttctta catatgccgt gatggcacca ctcgtcgctg gatctgtcac tgcttcatgg    780

ctgtcaagga cacaggtgaa aggttgagcc atgcagtagg ctgtgctttt gcagcctgtt    840

tagagcgcaa gcagaagcgg gagaaggaat gtggagtgac tgctactttt gatgctagtc    900

ggaccacttt tacaagagaa ggatcattcc gtgtcacaac agccactgaa caagcagaaa    960

gagaggagat catgaaacaa atgcaagatg ccaagaaagc tgaaacagat aagatagtcg   1020

ttggttcatc agttgcccct ggcaacactg ccccatcccc atcctctccc acctctccta   1080

cttctgatgc cacgacctct ctggagatga acaatcctca tgccatccca cgccggcatg   1140

ctccaattga acagcttgct cgccaaggct ctttccgagg ttttcctgct cttagccaga   1200

agatgtcacc ctttaaacgc caactatccc tacgcatcaa tgagttgcct tccactatgc   1260

agaggaagac tgatttcccc attaaaaatg cagtgccaga agtagaaggg gaggcagaga   1320

gcatcagctc cctgtgctca cagatcacca atgccttcag cacacctgag gaccccttct   1380

catctgctcc gatgaccaaa ccagtgacag tggtggcacc acaatctcct accttccaag   1440

ctaatggcac tgactcagcc ttccatgtgc ttgctaagcc agcccatact gctctagcac   1500

ccgtagcaat gcctgtgcgt gaaaccaacc cttgggccca tgcccctgat gctgctaaca   1560

aggaaattgc agccacatgt tcggggaccg agtggggtca atcttctggt gctgcctctc   1620

caggtctctt ccaggccggt catagacgta ctccctctga ggccgaccga tggttagaag   1680

aggtgtctaa gagcgtccgg gctcagcagc cccaggcctc agctgctcct ctgcagccag   1740

ttctccagcc tcctccaccc actgccatct cccagccagc atcacctttc caagggaatg   1800

cattcctcac ctctcagcct gtgccagtgg gtgtggtccc agccctgcaa ccagcctttg   1860

tccctgccca gtcctatcct gtggccaatg gaatgcccta tccagcccct aatgtgcctg   1920

tggtgggcat cactccctcc cagatggtgg ccaacgtatt tggcactgca ggccaccctc   1980

aggctgccca tccccatcag tcacccagcc tggtcaggca gcagacattc cctcactacg   2040

aggcaagcag tgctaccacc agtcccttct ttaagcctcc tgctcagcac ctcaacggtt   2100

ctgcagcttt caatggtgta gatgatggca ggttggcctc agcagacagg catacagagg   2160

ttcctacagg cacctgccca gtggatcctt ttgaagccca gtgggctgca ttagaaaata   2220

agtccaagca gcgtactaat ccctccccta ccaacccttt ctccagtgac ttacagaaga   2280

cgtttgaaat tgaactttaa gcaatcatta tggctatgta tcttgtccat accagacagg   2340

gagcaggggg tagcggtcaa aggagcaaaa cagactttgt ctcctgatta gtactctttt   2400

cactaatccc aaaggtccca aggaacaagt ccaggcccag agtactgtga ggggtgattt   2460

tgaaagacat gggaaaaagc attcctagag aaaagctgcc ttgcaattag gctaaagaag   2520

tcaaggaaat gttgctttct gtactccctc ttcccttacc cccttacaaa tctctggcaa   2580

cagagaggca aagtatctga acaagaatct atattccaag cacatttact gaaatgtaaa   2640

acacaacagg aagcaaagca atctcccttt gtttttcagg ccattcacct gcctcctgtc   2700

agtagtggcc tgtattagag atcaagaaga gtggtttgtg ctcaggctgg ggaacagaga   2760

ggcacgctat gctgccagaa ttcccaggag ggcatatcag caactgccca gcagagctat   2820

attttggggg agaagttgag cttccatttt gagtaacaga ataaatatta tatatatcaa   2880

aagccaaaat ctttattttt atgcatttag aatattttaa atagttctca gatattaaga   2940

agttgtatga gttgtaagta atcttgccaa aggtaaaggg gctagttgta agaaattgta   3000

cataagattg atttatcatt gatgcctact gaaataaaaa gaggaaaggc tggaagctgc   3060

agacaggatc cctagcttgt tttctgtcag tcattcattg taagtagcac attgcaacaa   3120

caatcatgct tatgaccaat acagtcacta ggttgtagtt ttttttaaat aaaggaaaag   3180

cagtattgtc ctggttttaa acctatgatg gaattctaat gtcattattt taatggaatc   3240

aatcgaaata tgctctatag agaatatatc ttttatatat tgctgcagtt tccttatgtt   3300

aatcctttaa cactaaggta acatgacata atcataccat agaagggaac acaggttacc   3360

atattggttt gtaatatggg tcttggtggg ttttgtttta tcctttaaat tttgttccca   3420

tgagttttgt ggggatgggg attctggttt tattagcttt gtgtgtgtcc tcttccccca   3480

aacccccttt tggtgagaac atccccttga cagttgcagc ctcttgacct cggataacaa   3540

taagagagct catctcattt ttacttttga acgttggcct tacaatcaaa tgtaagttat   3600

atatatttgt actgatgaaa atttataatc tgctttaaca aaaataaatg ttcatggtag   3660

aagcttttgc ccatgaaggg ctgttctttc ccctttcctt tattagtaaa tgaatttatt   3720

tttcgttctt ttggtcttac tctccattct actgctgctg taaatcccta g            3771


<210>  3088
<211>  651
<212>  PRT
<213>  Homo sapiens

<400>  3088


Met Asn Lys Leu Arg Gln Ser Phe Arg Arg Lys Lys Asp Val Tyr Val 
1               5                   10                  15      


Pro Glu Ala Ser Arg Pro His Gln Trp Gln Thr Asp Glu Glu Gly Val 
            20                  25                  30          


Arg Thr Gly Lys Cys Ser Phe Pro Val Lys Tyr Leu Gly His Val Glu 
        35                  40                  45              


Val Asp Glu Ser Arg Gly Met His Ile Cys Glu Asp Ala Val Lys Arg 
    50                  55                  60                  


Leu Lys Ala Glu Arg Lys Phe Phe Lys Gly Phe Phe Gly Lys Thr Gly 
65                  70                  75                  80  


Lys Lys Ala Val Lys Ala Val Leu Trp Val Ser Ala Asp Gly Leu Arg 
                85                  90                  95      


Val Val Asp Glu Lys Thr Lys Asp Leu Ile Val Asp Gln Thr Ile Glu 
            100                 105                 110         


Lys Val Ser Phe Cys Ala Pro Asp Arg Asn Phe Asp Arg Ala Phe Ser 
        115                 120                 125             


Tyr Ile Cys Arg Asp Gly Thr Thr Arg Arg Trp Ile Cys His Cys Phe 
    130                 135                 140                 


Met Ala Val Lys Asp Thr Gly Glu Arg Leu Ser His Ala Val Gly Cys 
145                 150                 155                 160 


Ala Phe Ala Ala Cys Leu Glu Arg Lys Gln Lys Arg Glu Lys Glu Cys 
                165                 170                 175     


Gly Val Thr Ala Thr Phe Asp Ala Ser Arg Thr Thr Phe Thr Arg Glu 
            180                 185                 190         


Gly Ser Phe Arg Val Thr Thr Ala Thr Glu Gln Ala Glu Arg Glu Glu 
        195                 200                 205             


Ile Met Lys Gln Met Gln Asp Ala Lys Lys Ala Glu Thr Asp Lys Ile 
    210                 215                 220                 


Val Val Gly Ser Ser Val Ala Pro Gly Asn Thr Ala Pro Ser Pro Ser 
225                 230                 235                 240 


Ser Pro Thr Ser Pro Thr Ser Asp Ala Thr Thr Ser Leu Glu Met Asn 
                245                 250                 255     


Asn Pro His Ala Ile Pro Arg Arg His Ala Pro Ile Glu Gln Leu Ala 
            260                 265                 270         


Arg Gln Gly Ser Phe Arg Gly Phe Pro Ala Leu Ser Gln Lys Met Ser 
        275                 280                 285             


Pro Phe Lys Arg Gln Leu Ser Leu Arg Ile Asn Glu Leu Pro Ser Thr 
    290                 295                 300                 


Met Gln Arg Lys Thr Asp Phe Pro Ile Lys Asn Ala Val Pro Glu Val 
305                 310                 315                 320 


Glu Gly Glu Ala Glu Ser Ile Ser Ser Leu Cys Ser Gln Ile Thr Asn 
                325                 330                 335     


Ala Phe Ser Thr Pro Glu Asp Pro Phe Ser Ser Ala Pro Met Thr Lys 
            340                 345                 350         


Pro Val Thr Val Val Ala Pro Gln Ser Pro Thr Phe Gln Ala Asn Gly 
        355                 360                 365             


Thr Asp Ser Ala Phe His Val Leu Ala Lys Pro Ala His Thr Ala Leu 
    370                 375                 380                 


Ala Pro Val Ala Met Pro Val Arg Glu Thr Asn Pro Trp Ala His Ala 
385                 390                 395                 400 


Pro Asp Ala Ala Asn Lys Glu Ile Ala Ala Thr Cys Ser Gly Thr Glu 
                405                 410                 415     


Trp Gly Gln Ser Ser Gly Ala Ala Ser Pro Gly Leu Phe Gln Ala Gly 
            420                 425                 430         


His Arg Arg Thr Pro Ser Glu Ala Asp Arg Trp Leu Glu Glu Val Ser 
        435                 440                 445             


Lys Ser Val Arg Ala Gln Gln Pro Gln Ala Ser Ala Ala Pro Leu Gln 
    450                 455                 460                 


Pro Val Leu Gln Pro Pro Pro Pro Thr Ala Ile Ser Gln Pro Ala Ser 
465                 470                 475                 480 


Pro Phe Gln Gly Asn Ala Phe Leu Thr Ser Gln Pro Val Pro Val Gly 
                485                 490                 495     


Val Val Pro Ala Leu Gln Pro Ala Phe Val Pro Ala Gln Ser Tyr Pro 
            500                 505                 510         


Val Ala Asn Gly Met Pro Tyr Pro Ala Pro Asn Val Pro Val Val Gly 
        515                 520                 525             


Ile Thr Pro Ser Gln Met Val Ala Asn Val Phe Gly Thr Ala Gly His 
    530                 535                 540                 


Pro Gln Ala Ala His Pro His Gln Ser Pro Ser Leu Val Arg Gln Gln 
545                 550                 555                 560 


Thr Phe Pro His Tyr Glu Ala Ser Ser Ala Thr Thr Ser Pro Phe Phe 
                565                 570                 575     


Lys Pro Pro Ala Gln His Leu Asn Gly Ser Ala Ala Phe Asn Gly Val 
            580                 585                 590         


Asp Asp Gly Arg Leu Ala Ser Ala Asp Arg His Thr Glu Val Pro Thr 
        595                 600                 605             


Gly Thr Cys Pro Val Asp Pro Phe Glu Ala Gln Trp Ala Ala Leu Glu 
    610                 615                 620                 


Asn Lys Ser Lys Gln Arg Thr Asn Pro Ser Pro Thr Asn Pro Phe Ser 
625                 630                 635                 640 


Ser Asp Leu Gln Lys Thr Phe Glu Ile Glu Leu 
                645                 650     

<210>  3089
<211>  3594
<212>  DNA
<213>  Homo sapiens

<400>  3089
agaagtatga aagagggtgg gcctgttgtc atgggggagg tggtggcgct tggtggccac     60

tggcggccga ggtagaggca gtggcgcttg agttggtcgg gggcagcggc agatttgagg    120

cttaagcaac ttcttccggg gaagagtgcc agtgcagcca ctgttacaat tcaagatctt    180

gatctatatc catagattgg aatattggtg ggccagcaat cctcagacgc ctcacttagg    240

acaaatgagg aaactgaggc ttggtgaagt tacgaaactt gtccaaaatc acacaacttg    300

taaagggcac agccaagatt cagagccagg ctgtaaaaat taaaatgaac aaattacggc    360

aaagttttag gagaaagaag gatgtttatg ttccagaggc cagtcgtcca catcagtggc    420

agacagatga agaaggcgtt cgcaccggaa aatgtagctt cccggttaag taccttggcc    480

atgtagaagt tgatgaatca agaggaatgc acatctgtga agatgctgta aaaagattga    540

aagctactgg aaagaaagca gttaaagcag ttctgtgggt ctcagcagat ggactcagag    600

ttgtggatga aaaaactaag gacctcatag ttgaccagac gatagagaaa gtttctttct    660

gtgccccaga caggaacttt gatagagcct tttcttacat atgccgtgat ggcaccactc    720

gtcgctggat ctgtcactgc ttcatggctg tcaaggacac aggtgaaagg ttgagccatg    780

cagtaggctg tgcttttgca gcctgtttag agcgcaagca gaagcgggag aaggaatgtg    840

gagtgactgc tacttttgat gctagtcgga ccacttttac aagagaagga tcattccgtg    900

tcacaacagc cactgaacaa gcagaaagag aggagatcat gaaacaaatg caagatgcca    960

agaaagctga aacagataag atagtcgttg gttcatcagt tgcccctggc aacactgccc   1020

catccccatc ctctcccacc tctcctactt ctgatgccac gacctctctg gagatgaaca   1080

atcctcatgc catcccacgc cggcatgctc caattgaaca gcttgctcgc caaggctctt   1140

tccgaggttt tcctgctctt agccagaaga tgtcaccctt taaacgccaa ctatccctac   1200

gcatcaatga gttgccttcc actatgcaga ggaagactga tttccccatt aaaaatgcag   1260

tgccagaagt agaaggggag gcagagagca tcagctccct gtgctcacag atcaccaatg   1320

ccttcagcac acctgaggac cccttctcat ctgctccgat gaccaaacca gtgacagtgg   1380

tggcaccaca atctcctacc ttccaaggga ccgagtgggg tcaatcttct ggtgctgcct   1440

ctccaggtct cttccaggcc ggtcatagac gtactccctc tgaggccgac cgatggttag   1500

aagaggtgtc taagagcgtc cgggctcagc agccccaggc ctcagctgct cctctgcagc   1560

cagttctcca gcctcctcca cccactgcca tctcccagcc agcatcacct ttccaaggga   1620

atgcattcct cacctctcag cctgtgccag tgggtgtggt cccagccctg caaccagcct   1680

ttgtccctgc ccagtcctat cctgtggcca atggaatgcc ctatccagcc cctaatgtgc   1740

ctgtggtggg catcactccc tcccagatgg tggccaacgt atttggcact gcaggccacc   1800

ctcaggctgc ccatccccat cagtcaccca gcctggtcag gcagcagaca ttccctcact   1860

acgaggcaag cagtgctacc accagtccct tctttaagcc tcctgctcag cacctcaacg   1920

gttctgcagc tttcaatggt gtagatgatg gcaggttggc ctcagcagac aggcatacag   1980

aggttcctac aggcacctgc ccagtggatc cttttgaagc ccagtgggct gcattagaaa   2040

ataagtccaa gcagcgtact aatccctccc ctaccaaccc tttctccagt gacttacaga   2100

agacgtttga aattgaactt taagcaatca ttatggctat gtatcttgtc cataccagac   2160

agggagcagg gggtagcggt caaaggagca aaacagactt tgtctcctga ttagtactct   2220

tttcactaat cccaaaggtc ccaaggaaca agtccaggcc cagagtactg tgaggggtga   2280

ttttgaaaga catgggaaaa agcattccta gagaaaagct gccttgcaat taggctaaag   2340

aagtcaagga aatgttgctt tctgtactcc ctcttccctt acccccttac aaatctctgg   2400

caacagagag gcaaagtatc tgaacaagaa tctatattcc aagcacattt actgaaatgt   2460

aaaacacaac aggaagcaaa gcaatctccc tttgtttttc aggccattca cctgcctcct   2520

gtcagtagtg gcctgtatta gagatcaaga agagtggttt gtgctcaggc tggggaacag   2580

agaggcacgc tatgctgcca gaattcccag gagggcatat cagcaactgc ccagcagagc   2640

tatattttgg gggagaagtt gagcttccat tttgagtaac agaataaata ttatatatat   2700

caaaagccaa aatctttatt tttatgcatt tagaatattt taaatagttc tcagatatta   2760

agaagttgta tgagttgtaa gtaatcttgc caaaggtaaa ggggctagtt gtaagaaatt   2820

gtacataaga ttgatttatc attgatgcct actgaaataa aaagaggaaa ggctggaagc   2880

tgcagacagg atccctagct tgttttctgt cagtcattca ttgtaagtag cacattgcaa   2940

caacaatcat gcttatgacc aatacagtca ctaggttgta gtttttttta aataaaggaa   3000

aagcagtatt gtcctggttt taaacctatg atggaattct aatgtcatta ttttaatgga   3060

atcaatcgaa atatgctcta tagagaatat atcttttata tattgctgca gtttccttat   3120

gttaatcctt taacactaag gtaacatgac ataatcatac catagaaggg aacacaggtt   3180

accatattgg tttgtaatat gggtcttggt gggttttgtt ttatccttta aattttgttc   3240

ccatgagttt tgtggggatg gggattctgg ttttattagc tttgtgtgtg tcctcttccc   3300

ccaaaccccc ttttggtgag aacatcccct tgacagttgc agcctcttga cctcggataa   3360

caataagaga gctcatctca tttttacttt tgaacgttgg ccttacaatc aaatgtaagt   3420

tatatatatt tgtactgatg aaaatttata atctgcttta acaaaaataa atgttcatgg   3480

tagaagcttt tgcccatgaa gggctgttct ttcccctttc ctttattagt aaatgaattt   3540

atttttcgtt cttttggtct tactctccat tctactgctg ctgtaaatcc ctag         3594


<210>  3090
<211>  592
<212>  PRT
<213>  Homo sapiens

<400>  3090


Met Asn Lys Leu Arg Gln Ser Phe Arg Arg Lys Lys Asp Val Tyr Val 
1               5                   10                  15      


Pro Glu Ala Ser Arg Pro His Gln Trp Gln Thr Asp Glu Glu Gly Val 
            20                  25                  30          


Arg Thr Gly Lys Cys Ser Phe Pro Val Lys Tyr Leu Gly His Val Glu 
        35                  40                  45              


Val Asp Glu Ser Arg Gly Met His Ile Cys Glu Asp Ala Val Lys Arg 
    50                  55                  60                  


Leu Lys Ala Thr Gly Lys Lys Ala Val Lys Ala Val Leu Trp Val Ser 
65                  70                  75                  80  


Ala Asp Gly Leu Arg Val Val Asp Glu Lys Thr Lys Asp Leu Ile Val 
                85                  90                  95      


Asp Gln Thr Ile Glu Lys Val Ser Phe Cys Ala Pro Asp Arg Asn Phe 
            100                 105                 110         


Asp Arg Ala Phe Ser Tyr Ile Cys Arg Asp Gly Thr Thr Arg Arg Trp 
        115                 120                 125             


Ile Cys His Cys Phe Met Ala Val Lys Asp Thr Gly Glu Arg Leu Ser 
    130                 135                 140                 


His Ala Val Gly Cys Ala Phe Ala Ala Cys Leu Glu Arg Lys Gln Lys 
145                 150                 155                 160 


Arg Glu Lys Glu Cys Gly Val Thr Ala Thr Phe Asp Ala Ser Arg Thr 
                165                 170                 175     


Thr Phe Thr Arg Glu Gly Ser Phe Arg Val Thr Thr Ala Thr Glu Gln 
            180                 185                 190         


Ala Glu Arg Glu Glu Ile Met Lys Gln Met Gln Asp Ala Lys Lys Ala 
        195                 200                 205             


Glu Thr Asp Lys Ile Val Val Gly Ser Ser Val Ala Pro Gly Asn Thr 
    210                 215                 220                 


Ala Pro Ser Pro Ser Ser Pro Thr Ser Pro Thr Ser Asp Ala Thr Thr 
225                 230                 235                 240 


Ser Leu Glu Met Asn Asn Pro His Ala Ile Pro Arg Arg His Ala Pro 
                245                 250                 255     


Ile Glu Gln Leu Ala Arg Gln Gly Ser Phe Arg Gly Phe Pro Ala Leu 
            260                 265                 270         


Ser Gln Lys Met Ser Pro Phe Lys Arg Gln Leu Ser Leu Arg Ile Asn 
        275                 280                 285             


Glu Leu Pro Ser Thr Met Gln Arg Lys Thr Asp Phe Pro Ile Lys Asn 
    290                 295                 300                 


Ala Val Pro Glu Val Glu Gly Glu Ala Glu Ser Ile Ser Ser Leu Cys 
305                 310                 315                 320 


Ser Gln Ile Thr Asn Ala Phe Ser Thr Pro Glu Asp Pro Phe Ser Ser 
                325                 330                 335     


Ala Pro Met Thr Lys Pro Val Thr Val Val Ala Pro Gln Ser Pro Thr 
            340                 345                 350         


Phe Gln Gly Thr Glu Trp Gly Gln Ser Ser Gly Ala Ala Ser Pro Gly 
        355                 360                 365             


Leu Phe Gln Ala Gly His Arg Arg Thr Pro Ser Glu Ala Asp Arg Trp 
    370                 375                 380                 


Leu Glu Glu Val Ser Lys Ser Val Arg Ala Gln Gln Pro Gln Ala Ser 
385                 390                 395                 400 


Ala Ala Pro Leu Gln Pro Val Leu Gln Pro Pro Pro Pro Thr Ala Ile 
                405                 410                 415     


Ser Gln Pro Ala Ser Pro Phe Gln Gly Asn Ala Phe Leu Thr Ser Gln 
            420                 425                 430         


Pro Val Pro Val Gly Val Val Pro Ala Leu Gln Pro Ala Phe Val Pro 
        435                 440                 445             


Ala Gln Ser Tyr Pro Val Ala Asn Gly Met Pro Tyr Pro Ala Pro Asn 
    450                 455                 460                 


Val Pro Val Val Gly Ile Thr Pro Ser Gln Met Val Ala Asn Val Phe 
465                 470                 475                 480 


Gly Thr Ala Gly His Pro Gln Ala Ala His Pro His Gln Ser Pro Ser 
                485                 490                 495     


Leu Val Arg Gln Gln Thr Phe Pro His Tyr Glu Ala Ser Ser Ala Thr 
            500                 505                 510         


Thr Ser Pro Phe Phe Lys Pro Pro Ala Gln His Leu Asn Gly Ser Ala 
        515                 520                 525             


Ala Phe Asn Gly Val Asp Asp Gly Arg Leu Ala Ser Ala Asp Arg His 
    530                 535                 540                 


Thr Glu Val Pro Thr Gly Thr Cys Pro Val Asp Pro Phe Glu Ala Gln 
545                 550                 555                 560 


Trp Ala Ala Leu Glu Asn Lys Ser Lys Gln Arg Thr Asn Pro Ser Pro 
                565                 570                 575     


Thr Asn Pro Phe Ser Ser Asp Leu Gln Lys Thr Phe Glu Ile Glu Leu 
            580                 585                 590         

<210>  3091
<211>  3738
<212>  DNA
<213>  Homo sapiens

<400>  3091
agaagtatga aagagggtgg gcctgttgtc atgggggagg tggtggcgct tggtggccac     60

tggcggccga ggtagaggca gtggcgcttg agttggtcgg gggcagcggc agatttgagg    120

cttaagcaac ttcttccggg gaagagtgcc agtgcagcca ctgttacaat tcaagatctt    180

gatctatatc catagattgg aatattggtg ggccagcaat cctcagacgc ctcacttagg    240

acaaatgagg aaactgaggc ttggtgaagt tacgaaactt gtccaaaatc acacaacttg    300

taaagggcac agccaagatt cagagccagg ctgtaaaaat taaaatgaac aaattacggc    360

aaagttttag gagaaagaag gatgtttatg ttccagaggc cagtcgtcca catcagtggc    420

agacagatga agaaggcgtt cgcaccggaa aatgtagctt cccggttaag taccttggcc    480

atgtagaagt tgatgaatca agaggaatgc acatctgtga agatgctgta aaaagattga    540

aagctactgg aaagaaagca gttaaagcag ttctgtgggt ctcagcagat ggactcagag    600

ttgtggatga aaaaactaag gacctcatag ttgaccagac gatagagaaa gtttctttct    660

gtgccccaga caggaacttt gatagagcct tttcttacat atgccgtgat ggcaccactc    720

gtcgctggat ctgtcactgc ttcatggctg tcaaggacac aggtgaaagg ttgagccatg    780

cagtaggctg tgcttttgca gcctgtttag agcgcaagca gaagcgggag aaggaatgtg    840

gagtgactgc tacttttgat gctagtcgga ccacttttac aagagaagga tcattccgtg    900

tcacaacagc cactgaacaa gcagaaagag aggagatcat gaaacaaatg caagatgcca    960

agaaagctga aacagataag atagtcgttg gttcatcagt tgcccctggc aacactgccc   1020

catccccatc ctctcccacc tctcctactt ctgatgccac gacctctctg gagatgaaca   1080

atcctcatgc catcccacgc cggcatgctc caattgaaca gcttgctcgc caaggctctt   1140

tccgaggttt tcctgctctt agccagaaga tgtcaccctt taaacgccaa ctatccctac   1200

gcatcaatga gttgccttcc actatgcaga ggaagactga tttccccatt aaaaatgcag   1260

tgccagaagt agaaggggag gcagagagca tcagctccct gtgctcacag atcaccaatg   1320

ccttcagcac acctgaggac cccttctcat ctgctccgat gaccaaacca gtgacagtgg   1380

tggcaccaca atctcctacc ttccaagcta atggcactga ctcagccttc catgtgcttg   1440

ctaagccagc ccatactgct ctagcacccg tagcaatgcc tgtgcgtgaa accaaccctt   1500

gggcccatgc ccctgatgct gctaacaagg aaattgcagc cacatgttcg gggaccgagt   1560

ggggtcaatc ttctggtgct gcctctccag gtctcttcca ggccggtcat agacgtactc   1620

cctctgaggc cgaccgatgg ttagaagagg tgtctaagag cgtccgggct cagcagcccc   1680

aggcctcagc tgctcctctg cagccagttc tccagcctcc tccacccact gccatctccc   1740

agccagcatc acctttccaa gggaatgcat tcctcacctc tcagcctgtg ccagtgggtg   1800

tggtcccagc cctgcaacca gcctttgtcc ctgcccagtc ctatcctgtg gccaatggaa   1860

tgccctatcc agcccctaat gtgcctgtgg tgggcatcac tccctcccag atggtggcca   1920

acgtatttgg cactgcaggc caccctcagg ctgcccatcc ccatcagtca cccagcctgg   1980

tcaggcagca gacattccct cactacgagg caagcagtgc taccaccagt cccttcttta   2040

agcctcctgc tcagcacctc aacggttctg cagctttcaa tggtgtagat gatggcaggt   2100

tggcctcagc agacaggcat acagaggttc ctacaggcac ctgcccagtg gatccttttg   2160

aagcccagtg ggctgcatta gaaaataagt ccaagcagcg tactaatccc tcccctacca   2220

accctttctc cagtgactta cagaagacgt ttgaaattga actttaagca atcattatgg   2280

ctatgtatct tgtccatacc agacagggag cagggggtag cggtcaaagg agcaaaacag   2340

actttgtctc ctgattagta ctcttttcac taatcccaaa ggtcccaagg aacaagtcca   2400

ggcccagagt actgtgaggg gtgattttga aagacatggg aaaaagcatt cctagagaaa   2460

agctgccttg caattaggct aaagaagtca aggaaatgtt gctttctgta ctccctcttc   2520

ccttaccccc ttacaaatct ctggcaacag agaggcaaag tatctgaaca agaatctata   2580

ttccaagcac atttactgaa atgtaaaaca caacaggaag caaagcaatc tccctttgtt   2640

tttcaggcca ttcacctgcc tcctgtcagt agtggcctgt attagagatc aagaagagtg   2700

gtttgtgctc aggctgggga acagagaggc acgctatgct gccagaattc ccaggagggc   2760

atatcagcaa ctgcccagca gagctatatt ttgggggaga agttgagctt ccattttgag   2820

taacagaata aatattatat atatcaaaag ccaaaatctt tatttttatg catttagaat   2880

attttaaata gttctcagat attaagaagt tgtatgagtt gtaagtaatc ttgccaaagg   2940

taaaggggct agttgtaaga aattgtacat aagattgatt tatcattgat gcctactgaa   3000

ataaaaagag gaaaggctgg aagctgcaga caggatccct agcttgtttt ctgtcagtca   3060

ttcattgtaa gtagcacatt gcaacaacaa tcatgcttat gaccaataca gtcactaggt   3120

tgtagttttt tttaaataaa ggaaaagcag tattgtcctg gttttaaacc tatgatggaa   3180

ttctaatgtc attattttaa tggaatcaat cgaaatatgc tctatagaga atatatcttt   3240

tatatattgc tgcagtttcc ttatgttaat cctttaacac taaggtaaca tgacataatc   3300

ataccataga agggaacaca ggttaccata ttggtttgta atatgggtct tggtgggttt   3360

tgttttatcc tttaaatttt gttcccatga gttttgtggg gatggggatt ctggttttat   3420

tagctttgtg tgtgtcctct tcccccaaac ccccttttgg tgagaacatc cccttgacag   3480

ttgcagcctc ttgacctcgg ataacaataa gagagctcat ctcattttta cttttgaacg   3540

ttggccttac aatcaaatgt aagttatata tatttgtact gatgaaaatt tataatctgc   3600

tttaacaaaa ataaatgttc atggtagaag cttttgccca tgaagggctg ttctttcccc   3660

tttcctttat tagtaaatga atttattttt cgttcttttg gtcttactct ccattctact   3720

gctgctgtaa atccctag                                                 3738


<210>  3092
<211>  640
<212>  PRT
<213>  Homo sapiens

<400>  3092


Met Asn Lys Leu Arg Gln Ser Phe Arg Arg Lys Lys Asp Val Tyr Val 
1               5                   10                  15      


Pro Glu Ala Ser Arg Pro His Gln Trp Gln Thr Asp Glu Glu Gly Val 
            20                  25                  30          


Arg Thr Gly Lys Cys Ser Phe Pro Val Lys Tyr Leu Gly His Val Glu 
        35                  40                  45              


Val Asp Glu Ser Arg Gly Met His Ile Cys Glu Asp Ala Val Lys Arg 
    50                  55                  60                  


Leu Lys Ala Thr Gly Lys Lys Ala Val Lys Ala Val Leu Trp Val Ser 
65                  70                  75                  80  


Ala Asp Gly Leu Arg Val Val Asp Glu Lys Thr Lys Asp Leu Ile Val 
                85                  90                  95      


Asp Gln Thr Ile Glu Lys Val Ser Phe Cys Ala Pro Asp Arg Asn Phe 
            100                 105                 110         


Asp Arg Ala Phe Ser Tyr Ile Cys Arg Asp Gly Thr Thr Arg Arg Trp 
        115                 120                 125             


Ile Cys His Cys Phe Met Ala Val Lys Asp Thr Gly Glu Arg Leu Ser 
    130                 135                 140                 


His Ala Val Gly Cys Ala Phe Ala Ala Cys Leu Glu Arg Lys Gln Lys 
145                 150                 155                 160 


Arg Glu Lys Glu Cys Gly Val Thr Ala Thr Phe Asp Ala Ser Arg Thr 
                165                 170                 175     


Thr Phe Thr Arg Glu Gly Ser Phe Arg Val Thr Thr Ala Thr Glu Gln 
            180                 185                 190         


Ala Glu Arg Glu Glu Ile Met Lys Gln Met Gln Asp Ala Lys Lys Ala 
        195                 200                 205             


Glu Thr Asp Lys Ile Val Val Gly Ser Ser Val Ala Pro Gly Asn Thr 
    210                 215                 220                 


Ala Pro Ser Pro Ser Ser Pro Thr Ser Pro Thr Ser Asp Ala Thr Thr 
225                 230                 235                 240 


Ser Leu Glu Met Asn Asn Pro His Ala Ile Pro Arg Arg His Ala Pro 
                245                 250                 255     


Ile Glu Gln Leu Ala Arg Gln Gly Ser Phe Arg Gly Phe Pro Ala Leu 
            260                 265                 270         


Ser Gln Lys Met Ser Pro Phe Lys Arg Gln Leu Ser Leu Arg Ile Asn 
        275                 280                 285             


Glu Leu Pro Ser Thr Met Gln Arg Lys Thr Asp Phe Pro Ile Lys Asn 
    290                 295                 300                 


Ala Val Pro Glu Val Glu Gly Glu Ala Glu Ser Ile Ser Ser Leu Cys 
305                 310                 315                 320 


Ser Gln Ile Thr Asn Ala Phe Ser Thr Pro Glu Asp Pro Phe Ser Ser 
                325                 330                 335     


Ala Pro Met Thr Lys Pro Val Thr Val Val Ala Pro Gln Ser Pro Thr 
            340                 345                 350         


Phe Gln Ala Asn Gly Thr Asp Ser Ala Phe His Val Leu Ala Lys Pro 
        355                 360                 365             


Ala His Thr Ala Leu Ala Pro Val Ala Met Pro Val Arg Glu Thr Asn 
    370                 375                 380                 


Pro Trp Ala His Ala Pro Asp Ala Ala Asn Lys Glu Ile Ala Ala Thr 
385                 390                 395                 400 


Cys Ser Gly Thr Glu Trp Gly Gln Ser Ser Gly Ala Ala Ser Pro Gly 
                405                 410                 415     


Leu Phe Gln Ala Gly His Arg Arg Thr Pro Ser Glu Ala Asp Arg Trp 
            420                 425                 430         


Leu Glu Glu Val Ser Lys Ser Val Arg Ala Gln Gln Pro Gln Ala Ser 
        435                 440                 445             


Ala Ala Pro Leu Gln Pro Val Leu Gln Pro Pro Pro Pro Thr Ala Ile 
    450                 455                 460                 


Ser Gln Pro Ala Ser Pro Phe Gln Gly Asn Ala Phe Leu Thr Ser Gln 
465                 470                 475                 480 


Pro Val Pro Val Gly Val Val Pro Ala Leu Gln Pro Ala Phe Val Pro 
                485                 490                 495     


Ala Gln Ser Tyr Pro Val Ala Asn Gly Met Pro Tyr Pro Ala Pro Asn 
            500                 505                 510         


Val Pro Val Val Gly Ile Thr Pro Ser Gln Met Val Ala Asn Val Phe 
        515                 520                 525             


Gly Thr Ala Gly His Pro Gln Ala Ala His Pro His Gln Ser Pro Ser 
    530                 535                 540                 


Leu Val Arg Gln Gln Thr Phe Pro His Tyr Glu Ala Ser Ser Ala Thr 
545                 550                 555                 560 


Thr Ser Pro Phe Phe Lys Pro Pro Ala Gln His Leu Asn Gly Ser Ala 
                565                 570                 575     


Ala Phe Asn Gly Val Asp Asp Gly Arg Leu Ala Ser Ala Asp Arg His 
            580                 585                 590         


Thr Glu Val Pro Thr Gly Thr Cys Pro Val Asp Pro Phe Glu Ala Gln 
        595                 600                 605             


Trp Ala Ala Leu Glu Asn Lys Ser Lys Gln Arg Thr Asn Pro Ser Pro 
    610                 615                 620                 


Thr Asn Pro Phe Ser Ser Asp Leu Gln Lys Thr Phe Glu Ile Glu Leu 
625                 630                 635                 640 

<210>  3093
<211>  3627
<212>  DNA
<213>  Homo sapiens

<400>  3093
agaagtatga aagagggtgg gcctgttgtc atgggggagg tggtggcgct tggtggccac     60

tggcggccga ggtagaggca gtggcgcttg agttggtcgg gggcagcggc agatttgagg    120

cttaagcaac ttcttccggg gaagagtgcc agtgcagcca ctgttacaat tcaagatctt    180

gatctatatc catagattgg aatattggtg ggccagcaat cctcagacgc ctcacttagg    240

acaaatgagg aaactgaggc ttggtgaagt tacgaaactt gtccaaaatc acacaacttg    300

taaagggcac agccaagatt cagagccagg ctgtaaaaat taaaatgaac aaattacggc    360

aaagttttag gagaaagaag gatgtttatg ttccagaggc cagtcgtcca catcagtggc    420

agacagatga agaaggcgtt cgcaccggaa aatgtagctt cccggttaag taccttggcc    480

atgtagaagt tgatgaatca agaggaatgc acatctgtga agatgctgta aaaagattga    540

aagctgaaag gaagttcttc aaaggcttct ttggaaaaac tggaaagaaa gcagttaaag    600

cagttctgtg ggtctcagca gatggactca gagttgtgga tgaaaaaact aaggacctca    660

tagttgacca gacgatagag aaagtttctt tctgtgcccc agacaggaac tttgatagag    720

ccttttctta catatgccgt gatggcacca ctcgtcgctg gatctgtcac tgcttcatgg    780

ctgtcaagga cacaggtgaa aggttgagcc atgcagtagg ctgtgctttt gcagcctgtt    840

tagagcgcaa gcagaagcgg gagaaggaat gtggagtgac tgctactttt gatgctagtc    900

ggaccacttt tacaagagaa ggatcattcc gtgtcacaac agccactgaa caagcagaaa    960

gagaggagat catgaaacaa atgcaagatg ccaagaaagc tgaaacagat aagatagtcg   1020

ttggttcatc agttgcccct ggcaacactg ccccatcccc atcctctccc acctctccta   1080

cttctgatgc cacgacctct ctggagatga acaatcctca tgccatccca cgccggcatg   1140

ctccaattga acagcttgct cgccaaggct ctttccgagg ttttcctgct cttagccaga   1200

agatgtcacc ctttaaacgc caactatccc tacgcatcaa tgagttgcct tccactatgc   1260

agaggaagac tgatttcccc attaaaaatg cagtgccaga agtagaaggg gaggcagaga   1320

gcatcagctc cctgtgctca cagatcacca atgccttcag cacacctgag gaccccttct   1380

catctgctcc gatgaccaaa ccagtgacag tggtggcacc acaatctcct accttccaag   1440

ggaccgagtg gggtcaatct tctggtgctg cctctccagg tctcttccag gccggtcata   1500

gacgtactcc ctctgaggcc gaccgatggt tagaagaggt gtctaagagc gtccgggctc   1560

agcagcccca ggcctcagct gctcctctgc agccagttct ccagcctcct ccacccactg   1620

ccatctccca gccagcatca cctttccaag ggaatgcatt cctcacctct cagcctgtgc   1680

cagtgggtgt ggtcccagcc ctgcaaccag cctttgtccc tgcccagtcc tatcctgtgg   1740

ccaatggaat gccctatcca gcccctaatg tgcctgtggt gggcatcact ccctcccaga   1800

tggtggccaa cgtatttggc actgcaggcc accctcaggc tgcccatccc catcagtcac   1860

ccagcctggt caggcagcag acattccctc actacgaggc aagcagtgct accaccagtc   1920

ccttctttaa gcctcctgct cagcacctca acggttctgc agctttcaat ggtgtagatg   1980

atggcaggtt ggcctcagca gacaggcata cagaggttcc tacaggcacc tgcccagtgg   2040

atccttttga agcccagtgg gctgcattag aaaataagtc caagcagcgt actaatccct   2100

cccctaccaa ccctttctcc agtgacttac agaagacgtt tgaaattgaa ctttaagcaa   2160

tcattatggc tatgtatctt gtccatacca gacagggagc agggggtagc ggtcaaagga   2220

gcaaaacaga ctttgtctcc tgattagtac tcttttcact aatcccaaag gtcccaagga   2280

acaagtccag gcccagagta ctgtgagggg tgattttgaa agacatggga aaaagcattc   2340

ctagagaaaa gctgccttgc aattaggcta aagaagtcaa ggaaatgttg ctttctgtac   2400

tccctcttcc cttaccccct tacaaatctc tggcaacaga gaggcaaagt atctgaacaa   2460

gaatctatat tccaagcaca tttactgaaa tgtaaaacac aacaggaagc aaagcaatct   2520

ccctttgttt ttcaggccat tcacctgcct cctgtcagta gtggcctgta ttagagatca   2580

agaagagtgg tttgtgctca ggctggggaa cagagaggca cgctatgctg ccagaattcc   2640

caggagggca tatcagcaac tgcccagcag agctatattt tgggggagaa gttgagcttc   2700

cattttgagt aacagaataa atattatata tatcaaaagc caaaatcttt atttttatgc   2760

atttagaata ttttaaatag ttctcagata ttaagaagtt gtatgagttg taagtaatct   2820

tgccaaaggt aaaggggcta gttgtaagaa attgtacata agattgattt atcattgatg   2880

cctactgaaa taaaaagagg aaaggctgga agctgcagac aggatcccta gcttgttttc   2940

tgtcagtcat tcattgtaag tagcacattg caacaacaat catgcttatg accaatacag   3000

tcactaggtt gtagtttttt ttaaataaag gaaaagcagt attgtcctgg ttttaaacct   3060

atgatggaat tctaatgtca ttattttaat ggaatcaatc gaaatatgct ctatagagaa   3120

tatatctttt atatattgct gcagtttcct tatgttaatc ctttaacact aaggtaacat   3180

gacataatca taccatagaa gggaacacag gttaccatat tggtttgtaa tatgggtctt   3240

ggtgggtttt gttttatcct ttaaattttg ttcccatgag ttttgtgggg atggggattc   3300

tggttttatt agctttgtgt gtgtcctctt cccccaaacc cccttttggt gagaacatcc   3360

ccttgacagt tgcagcctct tgacctcgga taacaataag agagctcatc tcatttttac   3420

ttttgaacgt tggccttaca atcaaatgta agttatatat atttgtactg atgaaaattt   3480

ataatctgct ttaacaaaaa taaatgttca tggtagaagc ttttgcccat gaagggctgt   3540

tctttcccct ttcctttatt agtaaatgaa tttatttttc gttcttttgg tcttactctc   3600

cattctactg ctgctgtaaa tccctag                                       3627


<210>  3094
<211>  603
<212>  PRT
<213>  Homo sapiens

<400>  3094


Met Asn Lys Leu Arg Gln Ser Phe Arg Arg Lys Lys Asp Val Tyr Val 
1               5                   10                  15      


Pro Glu Ala Ser Arg Pro His Gln Trp Gln Thr Asp Glu Glu Gly Val 
            20                  25                  30          


Arg Thr Gly Lys Cys Ser Phe Pro Val Lys Tyr Leu Gly His Val Glu 
        35                  40                  45              


Val Asp Glu Ser Arg Gly Met His Ile Cys Glu Asp Ala Val Lys Arg 
    50                  55                  60                  


Leu Lys Ala Glu Arg Lys Phe Phe Lys Gly Phe Phe Gly Lys Thr Gly 
65                  70                  75                  80  


Lys Lys Ala Val Lys Ala Val Leu Trp Val Ser Ala Asp Gly Leu Arg 
                85                  90                  95      


Val Val Asp Glu Lys Thr Lys Asp Leu Ile Val Asp Gln Thr Ile Glu 
            100                 105                 110         


Lys Val Ser Phe Cys Ala Pro Asp Arg Asn Phe Asp Arg Ala Phe Ser 
        115                 120                 125             


Tyr Ile Cys Arg Asp Gly Thr Thr Arg Arg Trp Ile Cys His Cys Phe 
    130                 135                 140                 


Met Ala Val Lys Asp Thr Gly Glu Arg Leu Ser His Ala Val Gly Cys 
145                 150                 155                 160 


Ala Phe Ala Ala Cys Leu Glu Arg Lys Gln Lys Arg Glu Lys Glu Cys 
                165                 170                 175     


Gly Val Thr Ala Thr Phe Asp Ala Ser Arg Thr Thr Phe Thr Arg Glu 
            180                 185                 190         


Gly Ser Phe Arg Val Thr Thr Ala Thr Glu Gln Ala Glu Arg Glu Glu 
        195                 200                 205             


Ile Met Lys Gln Met Gln Asp Ala Lys Lys Ala Glu Thr Asp Lys Ile 
    210                 215                 220                 


Val Val Gly Ser Ser Val Ala Pro Gly Asn Thr Ala Pro Ser Pro Ser 
225                 230                 235                 240 


Ser Pro Thr Ser Pro Thr Ser Asp Ala Thr Thr Ser Leu Glu Met Asn 
                245                 250                 255     


Asn Pro His Ala Ile Pro Arg Arg His Ala Pro Ile Glu Gln Leu Ala 
            260                 265                 270         


Arg Gln Gly Ser Phe Arg Gly Phe Pro Ala Leu Ser Gln Lys Met Ser 
        275                 280                 285             


Pro Phe Lys Arg Gln Leu Ser Leu Arg Ile Asn Glu Leu Pro Ser Thr 
    290                 295                 300                 


Met Gln Arg Lys Thr Asp Phe Pro Ile Lys Asn Ala Val Pro Glu Val 
305                 310                 315                 320 


Glu Gly Glu Ala Glu Ser Ile Ser Ser Leu Cys Ser Gln Ile Thr Asn 
                325                 330                 335     


Ala Phe Ser Thr Pro Glu Asp Pro Phe Ser Ser Ala Pro Met Thr Lys 
            340                 345                 350         


Pro Val Thr Val Val Ala Pro Gln Ser Pro Thr Phe Gln Gly Thr Glu 
        355                 360                 365             


Trp Gly Gln Ser Ser Gly Ala Ala Ser Pro Gly Leu Phe Gln Ala Gly 
    370                 375                 380                 


His Arg Arg Thr Pro Ser Glu Ala Asp Arg Trp Leu Glu Glu Val Ser 
385                 390                 395                 400 


Lys Ser Val Arg Ala Gln Gln Pro Gln Ala Ser Ala Ala Pro Leu Gln 
                405                 410                 415     


Pro Val Leu Gln Pro Pro Pro Pro Thr Ala Ile Ser Gln Pro Ala Ser 
            420                 425                 430         


Pro Phe Gln Gly Asn Ala Phe Leu Thr Ser Gln Pro Val Pro Val Gly 
        435                 440                 445             


Val Val Pro Ala Leu Gln Pro Ala Phe Val Pro Ala Gln Ser Tyr Pro 
    450                 455                 460                 


Val Ala Asn Gly Met Pro Tyr Pro Ala Pro Asn Val Pro Val Val Gly 
465                 470                 475                 480 


Ile Thr Pro Ser Gln Met Val Ala Asn Val Phe Gly Thr Ala Gly His 
                485                 490                 495     


Pro Gln Ala Ala His Pro His Gln Ser Pro Ser Leu Val Arg Gln Gln 
            500                 505                 510         


Thr Phe Pro His Tyr Glu Ala Ser Ser Ala Thr Thr Ser Pro Phe Phe 
        515                 520                 525             


Lys Pro Pro Ala Gln His Leu Asn Gly Ser Ala Ala Phe Asn Gly Val 
    530                 535                 540                 


Asp Asp Gly Arg Leu Ala Ser Ala Asp Arg His Thr Glu Val Pro Thr 
545                 550                 555                 560 


Gly Thr Cys Pro Val Asp Pro Phe Glu Ala Gln Trp Ala Ala Leu Glu 
                565                 570                 575     


Asn Lys Ser Lys Gln Arg Thr Asn Pro Ser Pro Thr Asn Pro Phe Ser 
            580                 585                 590         


Ser Asp Leu Gln Lys Thr Phe Glu Ile Glu Leu 
        595                 600             

<210>  3095
<211>  3456
<212>  DNA
<213>  Homo sapiens

<400>  3095
gcttgagttg gtcgggggca gcggcagctg agctgggatg ggagacccaa ctggcctggc     60

cgctccggct ctgaggatcc ctaagggacc aggaaagaag tcctcgagga gtggctcgcg    120

tttgagaccg ggatttgagg cttaagcaac ttcttccggg gaagagtgcc agtgcagcca    180

ctgttacaat tcaagatctt gatctatatc catagattgg aatattggtg ggccagcaat    240

cctcagacgc ctcacttagg acaagctgta aaaattaaaa tgaacaaatt acggcaaagt    300

tttaggagaa agaaggatgt ttatgttcca gaggccagtc gtccacatca gtggcagaca    360

gatgaagaag gcgttcgcac cggaaaatgt agcttcccgg ttaagtacct tggccatgta    420

gaagttgatg aatcaagagg aatgcacatc tgtgaagatg ctgtaaaaag attgaaagct    480

gaaaggaagt tcttcaaagg cttctttgga aaaactggaa agaaagcagt taaagcagtt    540

ctgtgggtct cagcagatgg actcagagtt gtggatgaaa aaactaagga cctcatagtt    600

gaccagacga tagagaaagt ttctttctgt gccccagaca ggaactttga tagagccttt    660

tcttacatat gccgtgatgg caccactcgt cgctggatct gtcactgctt catggctgtc    720

aaggacacag gtgaaaggtt gagccatgca gtaggctgtg cttttgcagc ctgtttagag    780

cgcaagcaga agcgggagaa ggaatgtgga gtgactgcta cttttgatgc tagtcggacc    840

acttttacaa gagaaggatc attccgtgtc acaacagcca ctgaacaagc agaaagagag    900

gagatcatga aacaaatgca agatgccaag aaagctgaaa cagataagat agtcgttggt    960

tcatcagttg cccctggcaa cactgcccca tccccatcct ctcccacctc tcctacttct   1020

gatgccacga cctctctgga gatgaacaat cctcatgcca tcccacgccg gcatgctcca   1080

attgaacagc ttgctcgcca aggctctttc cgaggttttc ctgctcttag ccagaagatg   1140

tcacccttta aacgccaact atccctacgc atcaatgagt tgccttccac tatgcagagg   1200

aagactgatt tccccattaa aaatgcagtg ccagaagtag aaggggaggc agagagcatc   1260

agctccctgt gctcacagat caccaatgcc ttcagcacac ctgaggaccc cttctcatct   1320

gctccgatga ccaaaccagt gacagtggtg gcaccacaat ctcctacctt ccaagggacc   1380

gagtggggtc aatcttctgg tgctgcctct ccaggtctct tccaggccgg tcatagacgt   1440

actccctctg aggccgaccg atggttagaa gaggtgtcta agagcgtccg ggctcagcag   1500

ccccaggcct cagctgctcc tctgcagcca gttctccagc ctcctccacc cactgccatc   1560

tcccagccag catcaccttt ccaagggaat gcattcctca cctctcagcc tgtgccagtg   1620

ggtgtggtcc cagccctgca accagccttt gtccctgccc agtcctatcc tgtggccaat   1680

ggaatgccct atccagcccc taatgtgcct gtggtgggca tcactccctc ccagatggtg   1740

gccaacgtat ttggcactgc aggccaccct caggctgccc atccccatca gtcacccagc   1800

ctggtcaggc agcagacatt ccctcactac gaggcaagca gtgctaccac cagtcccttc   1860

tttaagcctc ctgctcagca cctcaacggt tctgcagctt tcaatggtgt agatgatggc   1920

aggttggcct cagcagacag gcatacagag gttcctacag gcacctgccc agtggatcct   1980

tttgaagccc agtgggctgc attagaaaat aagtccaagc agcgtactaa tccctcccct   2040

accaaccctt tctccagtga cttacagaag acgtttgaaa ttgaacttta agcaatcatt   2100

atggctatgt atcttgtcca taccagacag ggagcagggg gtagcggtca aaggagcaaa   2160

acagactttg tctcctgatt agtactcttt tcactaatcc caaaggtccc aaggaacaag   2220

tccaggccca gagtactgtg aggggtgatt ttgaaagaca tgggaaaaag cattcctaga   2280

gaaaagctgc cttgcaatta ggctaaagaa gtcaaggaaa tgttgctttc tgtactccct   2340

cttcccttac ccccttacaa atctctggca acagagaggc aaagtatctg aacaagaatc   2400

tatattccaa gcacatttac tgaaatgtaa aacacaacag gaagcaaagc aatctccctt   2460

tgtttttcag gccattcacc tgcctcctgt cagtagtggc ctgtattaga gatcaagaag   2520

agtggtttgt gctcaggctg gggaacagag aggcacgcta tgctgccaga attcccagga   2580

gggcatatca gcaactgccc agcagagcta tattttgggg gagaagttga gcttccattt   2640

tgagtaacag aataaatatt atatatatca aaagccaaaa tctttatttt tatgcattta   2700

gaatatttta aatagttctc agatattaag aagttgtatg agttgtaagt aatcttgcca   2760

aaggtaaagg ggctagttgt aagaaattgt acataagatt gatttatcat tgatgcctac   2820

tgaaataaaa agaggaaagg ctggaagctg cagacaggat ccctagcttg ttttctgtca   2880

gtcattcatt gtaagtagca cattgcaaca acaatcatgc ttatgaccaa tacagtcact   2940

aggttgtagt tttttttaaa taaaggaaaa gcagtattgt cctggtttta aacctatgat   3000

ggaattctaa tgtcattatt ttaatggaat caatcgaaat atgctctata gagaatatat   3060

cttttatata ttgctgcagt ttccttatgt taatccttta acactaaggt aacatgacat   3120

aatcatacca tagaagggaa cacaggttac catattggtt tgtaatatgg gtcttggtgg   3180

gttttgtttt atcctttaaa ttttgttccc atgagttttg tggggatggg gattctggtt   3240

ttattagctt tgtgtgtgtc ctcttccccc aaaccccctt ttggtgagaa catccccttg   3300

acagttgcag cctcttgacc tcggataaca ataagagagc tcatctcatt tttacttttg   3360

aacgttggcc ttacaatcaa atgtaagtta tatatatttg tactgatgaa aatttataat   3420

ctgctttaac aaaaataaat gttcatggta gaagct                             3456


<210>  3096
<211>  603
<212>  PRT
<213>  Homo sapiens

<400>  3096


Met Asn Lys Leu Arg Gln Ser Phe Arg Arg Lys Lys Asp Val Tyr Val 
1               5                   10                  15      


Pro Glu Ala Ser Arg Pro His Gln Trp Gln Thr Asp Glu Glu Gly Val 
            20                  25                  30          


Arg Thr Gly Lys Cys Ser Phe Pro Val Lys Tyr Leu Gly His Val Glu 
        35                  40                  45              


Val Asp Glu Ser Arg Gly Met His Ile Cys Glu Asp Ala Val Lys Arg 
    50                  55                  60                  


Leu Lys Ala Glu Arg Lys Phe Phe Lys Gly Phe Phe Gly Lys Thr Gly 
65                  70                  75                  80  


Lys Lys Ala Val Lys Ala Val Leu Trp Val Ser Ala Asp Gly Leu Arg 
                85                  90                  95      


Val Val Asp Glu Lys Thr Lys Asp Leu Ile Val Asp Gln Thr Ile Glu 
            100                 105                 110         


Lys Val Ser Phe Cys Ala Pro Asp Arg Asn Phe Asp Arg Ala Phe Ser 
        115                 120                 125             


Tyr Ile Cys Arg Asp Gly Thr Thr Arg Arg Trp Ile Cys His Cys Phe 
    130                 135                 140                 


Met Ala Val Lys Asp Thr Gly Glu Arg Leu Ser His Ala Val Gly Cys 
145                 150                 155                 160 


Ala Phe Ala Ala Cys Leu Glu Arg Lys Gln Lys Arg Glu Lys Glu Cys 
                165                 170                 175     


Gly Val Thr Ala Thr Phe Asp Ala Ser Arg Thr Thr Phe Thr Arg Glu 
            180                 185                 190         


Gly Ser Phe Arg Val Thr Thr Ala Thr Glu Gln Ala Glu Arg Glu Glu 
        195                 200                 205             


Ile Met Lys Gln Met Gln Asp Ala Lys Lys Ala Glu Thr Asp Lys Ile 
    210                 215                 220                 


Val Val Gly Ser Ser Val Ala Pro Gly Asn Thr Ala Pro Ser Pro Ser 
225                 230                 235                 240 


Ser Pro Thr Ser Pro Thr Ser Asp Ala Thr Thr Ser Leu Glu Met Asn 
                245                 250                 255     


Asn Pro His Ala Ile Pro Arg Arg His Ala Pro Ile Glu Gln Leu Ala 
            260                 265                 270         


Arg Gln Gly Ser Phe Arg Gly Phe Pro Ala Leu Ser Gln Lys Met Ser 
        275                 280                 285             


Pro Phe Lys Arg Gln Leu Ser Leu Arg Ile Asn Glu Leu Pro Ser Thr 
    290                 295                 300                 


Met Gln Arg Lys Thr Asp Phe Pro Ile Lys Asn Ala Val Pro Glu Val 
305                 310                 315                 320 


Glu Gly Glu Ala Glu Ser Ile Ser Ser Leu Cys Ser Gln Ile Thr Asn 
                325                 330                 335     


Ala Phe Ser Thr Pro Glu Asp Pro Phe Ser Ser Ala Pro Met Thr Lys 
            340                 345                 350         


Pro Val Thr Val Val Ala Pro Gln Ser Pro Thr Phe Gln Gly Thr Glu 
        355                 360                 365             


Trp Gly Gln Ser Ser Gly Ala Ala Ser Pro Gly Leu Phe Gln Ala Gly 
    370                 375                 380                 


His Arg Arg Thr Pro Ser Glu Ala Asp Arg Trp Leu Glu Glu Val Ser 
385                 390                 395                 400 


Lys Ser Val Arg Ala Gln Gln Pro Gln Ala Ser Ala Ala Pro Leu Gln 
                405                 410                 415     


Pro Val Leu Gln Pro Pro Pro Pro Thr Ala Ile Ser Gln Pro Ala Ser 
            420                 425                 430         


Pro Phe Gln Gly Asn Ala Phe Leu Thr Ser Gln Pro Val Pro Val Gly 
        435                 440                 445             


Val Val Pro Ala Leu Gln Pro Ala Phe Val Pro Ala Gln Ser Tyr Pro 
    450                 455                 460                 


Val Ala Asn Gly Met Pro Tyr Pro Ala Pro Asn Val Pro Val Val Gly 
465                 470                 475                 480 


Ile Thr Pro Ser Gln Met Val Ala Asn Val Phe Gly Thr Ala Gly His 
                485                 490                 495     


Pro Gln Ala Ala His Pro His Gln Ser Pro Ser Leu Val Arg Gln Gln 
            500                 505                 510         


Thr Phe Pro His Tyr Glu Ala Ser Ser Ala Thr Thr Ser Pro Phe Phe 
        515                 520                 525             


Lys Pro Pro Ala Gln His Leu Asn Gly Ser Ala Ala Phe Asn Gly Val 
    530                 535                 540                 


Asp Asp Gly Arg Leu Ala Ser Ala Asp Arg His Thr Glu Val Pro Thr 
545                 550                 555                 560 


Gly Thr Cys Pro Val Asp Pro Phe Glu Ala Gln Trp Ala Ala Leu Glu 
                565                 570                 575     


Asn Lys Ser Lys Gln Arg Thr Asn Pro Ser Pro Thr Asn Pro Phe Ser 
            580                 585                 590         


Ser Asp Leu Gln Lys Thr Phe Glu Ile Glu Leu 
        595                 600             

<210>  3097
<211>  3558
<212>  DNA
<213>  Homo sapiens

<400>  3097
ctgttgtcat gggggaggtg gtggcgcttg gtggccactg gcggccgagg tagaggcagt     60

ggcgcttgag ttggtcgggg gcagcggcag atttgaggct taagcaactt cttccgggga    120

agagtgccag tgcagccact gttacaattc aagatcttga tctatatcca tagattggaa    180

tattggtggg ccagcaatcc tcagacgcct cacttaggac aagctgtaaa aattaaaatg    240

aacaaattac ggcaaagttt taggagaaag aaggatgttt atgttccaga ggccagtcgt    300

ccacatcagt ggcagacaga tgaagaaggc gttcgcaccg gaaaatgtag cttcccggtt    360

aagtaccttg gccatgtaga agttgatgaa tcaagaggaa tgcacatctg tgaagatgct    420

gtaaaaagat tgaaagctga aaggaagttc ttcaaaggct tctttggaaa aactggaaag    480

aaagcagtta aagcagttct gtgggtctca gcagatggac tcagagttgt ggatgaaaaa    540

actaaggacc tcatagttga ccagacgata gagaaagttt ctttctgtgc cccagacagg    600

aactttgata gagccttttc ttacatatgc cgtgatggca ccactcgtcg ctggatctgt    660

cactgcttca tggctgtcaa ggacacaggt gaaaggttga gccatgcagt aggctgtgct    720

tttgcagcct gtttagagcg caagcagaag cgggagaagg aatgtggagt gactgctact    780

tttgatgcta gtcggaccac ttttacaaga gaaggatcat tccgtgtcac aacagccact    840

gaacaagcag aaagagagga gatcatgaaa caaatgcaag atgccaagaa agctgaaaca    900

gataagatag tcgttggttc atcagttgcc cctggcaaca ctgccccatc cccatcctct    960

cccacctctc ctacttctga tgccacgacc tctctggaga tgaacaatcc tcatgccatc   1020

ccacgccggc atgctccaat tgaacagctt gctcgccaag gctctttccg aggttttcct   1080

gctcttagcc agaagatgtc accctttaaa cgccaactat ccctacgcat caatgagttg   1140

ccttccacta tgcagaggaa gactgatttc cccattaaaa atgcagtgcc agaagtagaa   1200

ggggaggcag agagcatcag ctccctgtgc tcacagatca ccaatgcctt cagcacacct   1260

gaggacccct tctcatctgc tccgatgacc aaaccagtga cagtggtggc accacaatct   1320

cctaccttcc aagctaatgg cactgactca gccttccatg tgcttgctaa gccagcccat   1380

actgctctag cacccgtagc aatgcctgtg cgtgaaacca acccttgggc ccatgcccct   1440

gatgctgcta acaaggaaat tgcagccaca tgttcgggga ccgagtgggg tcaatcttct   1500

ggtgctgcct ctccaggtct cttccaggcc ggtcatagac gtactccctc tgaggccgac   1560

cgatggttag aagaggtgtc taagagcgtc cgggctcagc agccccaggc ctcagctgct   1620

cctctgcagc cagttctcca gcctcctcca cccactgcca tctcccagcc agcatcacct   1680

ttccaaggga atgcattcct cacctctcag cctgtgccag tgggtgtggt cccagccctg   1740

caaccagcct ttgtccctgc ccagtcctat cctgtggcca atggaatgcc ctatccagcc   1800

cctaatgtgc ctgtggtggg catcactccc tcccagatgg tggccaacgt atttggcact   1860

gcaggccacc ctcaggctgc ccatccccat cagtcaccca gcctggtcag gcagcagaca   1920

ttccctcact acgaggcaag cagtgctacc accagtccct tctttaagcc tcctgctcag   1980

cacctcaacg gttctgcagc tttcaatggt gtagatgatg gcaggttggc ctcagcagac   2040

aggcatacag aggttcctac aggcacctgc ccagtggatc cttttgaagc ccagtgggct   2100

gcattagaaa ataagtccaa gcagcgtact aatccctccc ctaccaaccc tttctccagt   2160

gacttacaga agacgtttga aattgaactt taagcaatca ttatggctat gtatcttgtc   2220

cataccagac agggagcagg gggtagcggt caaaggagca aaacagactt tgtctcctga   2280

ttagtactct tttcactaat cccaaaggtc ccaaggaaca agtccaggcc cagagtactg   2340

tgaggggtga ttttgaaaga catgggaaaa agcattccta gagaaaagct gccttgcaat   2400

taggctaaag aagtcaagga aatgttgctt tctgtactcc ctcttccctt acccccttac   2460

aaatctctgg caacagagag gcaaagtatc tgaacaagaa tctatattcc aagcacattt   2520

actgaaatgt aaaacacaac aggaagcaaa gcaatctccc tttgtttttc aggccattca   2580

cctgcctcct gtcagtagtg gcctgtatta gagatcaaga agagtggttt gtgctcaggc   2640

tggggaacag agaggcacgc tatgctgcca gaattcccag gagggcatat cagcaactgc   2700

ccagcagagc tatattttgg gggagaagtt gagcttccat tttgagtaac agaataaata   2760

ttatatatat caaaagccaa aatctttatt tttatgcatt tagaatattt taaatagttc   2820

tcagatatta agaagttgta tgagttgtaa gtaatcttgc caaaggtaaa ggggctagtt   2880

gtaagaaatt gtacataaga ttgatttatc attgatgcct actgaaataa aaagaggaaa   2940

ggctggaagc tgcagacagg atccctagct tgttttctgt cagtcattca ttgtaagtag   3000

cacattgcaa caacaatcat gcttatgacc aatacagtca ctaggttgta gtttttttta   3060

aataaaggaa aagcagtatt gtcctggttt taaacctatg atggaattct aatgtcatta   3120

ttttaatgga atcaatcgaa atatgctcta tagagaatat atcttttata tattgctgca   3180

gtttccttat gttaatcctt taacactaag gtaacatgac ataatcatac catagaaggg   3240

aacacaggtt accatattgg tttgtaatat gggtcttggt gggttttgtt ttatccttta   3300

aattttgttc ccatgagttt tgtggggatg gggattctgg ttttattagc tttgtgtgtg   3360

tcctcttccc ccaaaccccc ttttggtgag aacatcccct tgacagttgc agcctcttga   3420

cctcggataa caataagaga gctcatctca tttttacttt tgaacgttgg ccttacaatc   3480

aaatgtaagt tatatatatt tgtactgatg aaaatttata atctgcttta acaaaaataa   3540

atgttcatgg tagaagct                                                 3558


<210>  3098
<211>  651
<212>  PRT
<213>  Homo sapiens

<400>  3098


Met Asn Lys Leu Arg Gln Ser Phe Arg Arg Lys Lys Asp Val Tyr Val 
1               5                   10                  15      


Pro Glu Ala Ser Arg Pro His Gln Trp Gln Thr Asp Glu Glu Gly Val 
            20                  25                  30          


Arg Thr Gly Lys Cys Ser Phe Pro Val Lys Tyr Leu Gly His Val Glu 
        35                  40                  45              


Val Asp Glu Ser Arg Gly Met His Ile Cys Glu Asp Ala Val Lys Arg 
    50                  55                  60                  


Leu Lys Ala Glu Arg Lys Phe Phe Lys Gly Phe Phe Gly Lys Thr Gly 
65                  70                  75                  80  


Lys Lys Ala Val Lys Ala Val Leu Trp Val Ser Ala Asp Gly Leu Arg 
                85                  90                  95      


Val Val Asp Glu Lys Thr Lys Asp Leu Ile Val Asp Gln Thr Ile Glu 
            100                 105                 110         


Lys Val Ser Phe Cys Ala Pro Asp Arg Asn Phe Asp Arg Ala Phe Ser 
        115                 120                 125             


Tyr Ile Cys Arg Asp Gly Thr Thr Arg Arg Trp Ile Cys His Cys Phe 
    130                 135                 140                 


Met Ala Val Lys Asp Thr Gly Glu Arg Leu Ser His Ala Val Gly Cys 
145                 150                 155                 160 


Ala Phe Ala Ala Cys Leu Glu Arg Lys Gln Lys Arg Glu Lys Glu Cys 
                165                 170                 175     


Gly Val Thr Ala Thr Phe Asp Ala Ser Arg Thr Thr Phe Thr Arg Glu 
            180                 185                 190         


Gly Ser Phe Arg Val Thr Thr Ala Thr Glu Gln Ala Glu Arg Glu Glu 
        195                 200                 205             


Ile Met Lys Gln Met Gln Asp Ala Lys Lys Ala Glu Thr Asp Lys Ile 
    210                 215                 220                 


Val Val Gly Ser Ser Val Ala Pro Gly Asn Thr Ala Pro Ser Pro Ser 
225                 230                 235                 240 


Ser Pro Thr Ser Pro Thr Ser Asp Ala Thr Thr Ser Leu Glu Met Asn 
                245                 250                 255     


Asn Pro His Ala Ile Pro Arg Arg His Ala Pro Ile Glu Gln Leu Ala 
            260                 265                 270         


Arg Gln Gly Ser Phe Arg Gly Phe Pro Ala Leu Ser Gln Lys Met Ser 
        275                 280                 285             


Pro Phe Lys Arg Gln Leu Ser Leu Arg Ile Asn Glu Leu Pro Ser Thr 
    290                 295                 300                 


Met Gln Arg Lys Thr Asp Phe Pro Ile Lys Asn Ala Val Pro Glu Val 
305                 310                 315                 320 


Glu Gly Glu Ala Glu Ser Ile Ser Ser Leu Cys Ser Gln Ile Thr Asn 
                325                 330                 335     


Ala Phe Ser Thr Pro Glu Asp Pro Phe Ser Ser Ala Pro Met Thr Lys 
            340                 345                 350         


Pro Val Thr Val Val Ala Pro Gln Ser Pro Thr Phe Gln Ala Asn Gly 
        355                 360                 365             


Thr Asp Ser Ala Phe His Val Leu Ala Lys Pro Ala His Thr Ala Leu 
    370                 375                 380                 


Ala Pro Val Ala Met Pro Val Arg Glu Thr Asn Pro Trp Ala His Ala 
385                 390                 395                 400 


Pro Asp Ala Ala Asn Lys Glu Ile Ala Ala Thr Cys Ser Gly Thr Glu 
                405                 410                 415     


Trp Gly Gln Ser Ser Gly Ala Ala Ser Pro Gly Leu Phe Gln Ala Gly 
            420                 425                 430         


His Arg Arg Thr Pro Ser Glu Ala Asp Arg Trp Leu Glu Glu Val Ser 
        435                 440                 445             


Lys Ser Val Arg Ala Gln Gln Pro Gln Ala Ser Ala Ala Pro Leu Gln 
    450                 455                 460                 


Pro Val Leu Gln Pro Pro Pro Pro Thr Ala Ile Ser Gln Pro Ala Ser 
465                 470                 475                 480 


Pro Phe Gln Gly Asn Ala Phe Leu Thr Ser Gln Pro Val Pro Val Gly 
                485                 490                 495     


Val Val Pro Ala Leu Gln Pro Ala Phe Val Pro Ala Gln Ser Tyr Pro 
            500                 505                 510         


Val Ala Asn Gly Met Pro Tyr Pro Ala Pro Asn Val Pro Val Val Gly 
        515                 520                 525             


Ile Thr Pro Ser Gln Met Val Ala Asn Val Phe Gly Thr Ala Gly His 
    530                 535                 540                 


Pro Gln Ala Ala His Pro His Gln Ser Pro Ser Leu Val Arg Gln Gln 
545                 550                 555                 560 


Thr Phe Pro His Tyr Glu Ala Ser Ser Ala Thr Thr Ser Pro Phe Phe 
                565                 570                 575     


Lys Pro Pro Ala Gln His Leu Asn Gly Ser Ala Ala Phe Asn Gly Val 
            580                 585                 590         


Asp Asp Gly Arg Leu Ala Ser Ala Asp Arg His Thr Glu Val Pro Thr 
        595                 600                 605             


Gly Thr Cys Pro Val Asp Pro Phe Glu Ala Gln Trp Ala Ala Leu Glu 
    610                 615                 620                 


Asn Lys Ser Lys Gln Arg Thr Asn Pro Ser Pro Thr Asn Pro Phe Ser 
625                 630                 635                 640 


Ser Asp Leu Gln Lys Thr Phe Glu Ile Glu Leu 
                645                 650     

<210>  3099
<211>  3521
<212>  DNA
<213>  Homo sapiens

<400>  3099
agaagtatga aagagggtgg gcctgttgtc atgggggagg tggtggcgct tggtggccac     60

tggcggccga ggtagaggca gtggcgcttg agttggtcgg gggcagcggc agatttgagg    120

cttaagcaac ttcttccggg gaagagtgcc agtgcagcca ctgttacaat tcaagatctt    180

gatctatatc catagattgg aatattggtg ggccagcaat cctcagacgc ctcacttagg    240

acaaatgagg aaactgaggc ttggtgaagt tacgaaactt gtccaaaatc acacaacttg    300

taaagggcac agccaagatt cagagccagg ctgtaaaaat taaaatgaac aaattacggc    360

aaagttttag gagaaagaag gatgtttatg ttccagaggc cagtcgtcca catcagtggc    420

agacagatga agaaggcgtt cgcaccggaa aatgtagctt cccggttaag taccttggcc    480

atgtagaagt tgatgaatca agaggaatgc acatctgtga agatgctgta aaaagattga    540

aagctgaaag gaagttcttc aaaggcttct ttggaaaaac tggaaagaaa gcagttaaag    600

cagttctgtg ggtctcagca gatggactca gagttgtgga tgaaaaaact aaggacctca    660

tagttgacca gacgatagag aaagtttctt tctgtgcccc agacaggaac tttgatagag    720

ccttttctta catatgccgt gatggcacca ctcgtcgctg gatctgtcac tgcttcatgg    780

ctgtcaagga cacaggtgaa aggttgagcc atgcagtagg ctgtgctttt gcagcctgtt    840

tagagcgcaa gcagaagcgg gagaaggaat gtggagtgac tgctactttt gatgctagtc    900

ggaccacttt tacaagagaa ggatcattcc gtgtcacaac agccactgaa caagcagaaa    960

gagaggagat catgaaacaa atgcaagatg ccaagaaagc tgaaacagat aagatagtcg   1020

ttggttcatc agttgcccct ggcaacactg ccccatcccc atcctctccc acctctccta   1080

cttctgatgc cacgacctct ctggagatga acaatcctca tgccatccca cgccggcatg   1140

ctccaattga acagcttgct cgccaaggct ctttccgagg ttttcctgct cttagccaga   1200

agatgtcacc ctttaaacgc caactatccc tacgcatcaa tgagttgcct tccactatgc   1260

agaggaagac tgatttcccc attaaaaatg cagtgccaga agtagaaggg gaggcagaga   1320

gcatcagctc cctgtgctca cagatcacca atgccttcag cacacctgag gaccccttct   1380

catctgctcc gatgaccaaa ccagtgacag tggtggcacc acaatctcct accttccaag   1440

ggaccgagtg gggtcaatct tctggtgctg cctctccagg tctcttccag gccggtcata   1500

gacgtactcc ctctgaggcc gaccgatggt tagaagaggt gtctaagagc gtccgggctc   1560

agcagcccca ggcctcagct gctcctctgc agccagttct ccagcctcct ccacccactg   1620

ccatctccca gccagcatca cctttccaag ggaatgcatt cctcacctct cagcctgtgc   1680

cagtgggtgt ggtcccagcc ctgcaaccag cctttgtccc tgcccagtcc tatcctgtgg   1740

ccaatggaat gccctatcca gcccctaatg tgcctgtggt gggcatcact ccctcccaga   1800

tggtggccaa cgtatttggc actgcaggcc accctcaggc tgcccatccc catcagtcac   1860

ccagcctggt caggcagcag acattccctc actacgaggc aagcagtgct accaccagtc   1920

ccttctttaa gcctcctgct cagcacctca acggttctgc agctttcaat ggtgtagatg   1980

atggcaggtt ggcctcagca gacaggcata cagaggttcc tacaggcacc tgcccagtgg   2040

atccttttga agcccagtgg gctgcattag aaaataagtc caagcagcgt actaatccct   2100

cccctaccaa ccctttctcc agtgacttac agaagacgtt tgaaattgaa ctttaagcaa   2160

tcattatggc tatgtatctt gtccatacca gacagggagc agggggtagc ggtcaaagga   2220

gcaaaacaga ctttgtctcc tgattagtac tcttttcact aatcccaaag gtcccaagga   2280

acaagtccag gcccagagta ctgtgagggg tgattttgaa agacatggga aaaagcattc   2340

ctagagaaaa gctgccttgc aattaggcta aagaagtcaa ggaaatgttg ctttctgtac   2400

tccctcttcc cttaccccct tacaaatctc tggcaacaga gaggcaaagt atctgaacaa   2460

gaatctatat tccaagcaca tttactgaaa tgtaaaacac aacaggaagc aaagcaatct   2520

ccctttgttt ttcaggccat tcacctgcct cctgtcagta gtggcctgta ttagagatca   2580

agaagagtgg tttgtgctca ggctggggaa cagagaggca cgctatgctg ccagaattcc   2640

caggagggca tatcagcaac tgcccagcag agctatattt tgggggagaa gttgagcttc   2700

cattttgagt aacagaataa atattatata tatcaaaagc caaaatcttt atttttatgc   2760

atttagaata ttttaaatag ttctcagata ttaagaagtt gtatgagttg taagtaatct   2820

tgccaaaggt aaaggggcta gttgtaagaa attgtacata agattgattt atcattgatg   2880

cctactgaaa taaaaagagg aaaggctgga agctgcagac aggatcccta gcttgttttc   2940

tgtcagtcat tcattgtaag tagcacattg caacaacaat catgcttatg accaatacag   3000

tcactaggtt gtagtttttt ttaaataaag gaaaagcagt attgtcctgg ttttaaacct   3060

atgatggaat tctaatgtca ttattttaat ggaatcaatc gaaatatgct ctatagagaa   3120

tatatctttt atatattgct gcagtttcct tatgttaatc ctttaacact aaggtaacat   3180

gacataatca taccatagaa gggaacacag gttaccatat tggtttgtaa tatgggtctt   3240

ggtgggtttt gttttatcct ttaaattttg ttcccatgag ttttgtgggg atggggattc   3300

tggttttatt agctttgtgt gtgtcctctt cccccaaacc cccttttggt gagaacatcc   3360

ccttgacagt tgcagcctct tgacctcgga taacaataag agagctcatc tcatttttac   3420

ttttgaacgt tggccttaca atcaaatgta agttatatat atttgtactg atgaaaattt   3480

ataatctgct ttaacaaaaa taaatgttca tggtagaagc t                       3521


<210>  3100
<211>  603
<212>  PRT
<213>  Homo sapiens

<400>  3100


Met Asn Lys Leu Arg Gln Ser Phe Arg Arg Lys Lys Asp Val Tyr Val 
1               5                   10                  15      


Pro Glu Ala Ser Arg Pro His Gln Trp Gln Thr Asp Glu Glu Gly Val 
            20                  25                  30          


Arg Thr Gly Lys Cys Ser Phe Pro Val Lys Tyr Leu Gly His Val Glu 
        35                  40                  45              


Val Asp Glu Ser Arg Gly Met His Ile Cys Glu Asp Ala Val Lys Arg 
    50                  55                  60                  


Leu Lys Ala Glu Arg Lys Phe Phe Lys Gly Phe Phe Gly Lys Thr Gly 
65                  70                  75                  80  


Lys Lys Ala Val Lys Ala Val Leu Trp Val Ser Ala Asp Gly Leu Arg 
                85                  90                  95      


Val Val Asp Glu Lys Thr Lys Asp Leu Ile Val Asp Gln Thr Ile Glu 
            100                 105                 110         


Lys Val Ser Phe Cys Ala Pro Asp Arg Asn Phe Asp Arg Ala Phe Ser 
        115                 120                 125             


Tyr Ile Cys Arg Asp Gly Thr Thr Arg Arg Trp Ile Cys His Cys Phe 
    130                 135                 140                 


Met Ala Val Lys Asp Thr Gly Glu Arg Leu Ser His Ala Val Gly Cys 
145                 150                 155                 160 


Ala Phe Ala Ala Cys Leu Glu Arg Lys Gln Lys Arg Glu Lys Glu Cys 
                165                 170                 175     


Gly Val Thr Ala Thr Phe Asp Ala Ser Arg Thr Thr Phe Thr Arg Glu 
            180                 185                 190         


Gly Ser Phe Arg Val Thr Thr Ala Thr Glu Gln Ala Glu Arg Glu Glu 
        195                 200                 205             


Ile Met Lys Gln Met Gln Asp Ala Lys Lys Ala Glu Thr Asp Lys Ile 
    210                 215                 220                 


Val Val Gly Ser Ser Val Ala Pro Gly Asn Thr Ala Pro Ser Pro Ser 
225                 230                 235                 240 


Ser Pro Thr Ser Pro Thr Ser Asp Ala Thr Thr Ser Leu Glu Met Asn 
                245                 250                 255     


Asn Pro His Ala Ile Pro Arg Arg His Ala Pro Ile Glu Gln Leu Ala 
            260                 265                 270         


Arg Gln Gly Ser Phe Arg Gly Phe Pro Ala Leu Ser Gln Lys Met Ser 
        275                 280                 285             


Pro Phe Lys Arg Gln Leu Ser Leu Arg Ile Asn Glu Leu Pro Ser Thr 
    290                 295                 300                 


Met Gln Arg Lys Thr Asp Phe Pro Ile Lys Asn Ala Val Pro Glu Val 
305                 310                 315                 320 


Glu Gly Glu Ala Glu Ser Ile Ser Ser Leu Cys Ser Gln Ile Thr Asn 
                325                 330                 335     


Ala Phe Ser Thr Pro Glu Asp Pro Phe Ser Ser Ala Pro Met Thr Lys 
            340                 345                 350         


Pro Val Thr Val Val Ala Pro Gln Ser Pro Thr Phe Gln Gly Thr Glu 
        355                 360                 365             


Trp Gly Gln Ser Ser Gly Ala Ala Ser Pro Gly Leu Phe Gln Ala Gly 
    370                 375                 380                 


His Arg Arg Thr Pro Ser Glu Ala Asp Arg Trp Leu Glu Glu Val Ser 
385                 390                 395                 400 


Lys Ser Val Arg Ala Gln Gln Pro Gln Ala Ser Ala Ala Pro Leu Gln 
                405                 410                 415     


Pro Val Leu Gln Pro Pro Pro Pro Thr Ala Ile Ser Gln Pro Ala Ser 
            420                 425                 430         


Pro Phe Gln Gly Asn Ala Phe Leu Thr Ser Gln Pro Val Pro Val Gly 
        435                 440                 445             


Val Val Pro Ala Leu Gln Pro Ala Phe Val Pro Ala Gln Ser Tyr Pro 
    450                 455                 460                 


Val Ala Asn Gly Met Pro Tyr Pro Ala Pro Asn Val Pro Val Val Gly 
465                 470                 475                 480 


Ile Thr Pro Ser Gln Met Val Ala Asn Val Phe Gly Thr Ala Gly His 
                485                 490                 495     


Pro Gln Ala Ala His Pro His Gln Ser Pro Ser Leu Val Arg Gln Gln 
            500                 505                 510         


Thr Phe Pro His Tyr Glu Ala Ser Ser Ala Thr Thr Ser Pro Phe Phe 
        515                 520                 525             


Lys Pro Pro Ala Gln His Leu Asn Gly Ser Ala Ala Phe Asn Gly Val 
    530                 535                 540                 


Asp Asp Gly Arg Leu Ala Ser Ala Asp Arg His Thr Glu Val Pro Thr 
545                 550                 555                 560 


Gly Thr Cys Pro Val Asp Pro Phe Glu Ala Gln Trp Ala Ala Leu Glu 
                565                 570                 575     


Asn Lys Ser Lys Gln Arg Thr Asn Pro Ser Pro Thr Asn Pro Phe Ser 
            580                 585                 590         


Ser Asp Leu Gln Lys Thr Phe Glu Ile Glu Leu 
        595                 600             

<210>  3101
<211>  3632
<212>  DNA
<213>  Homo sapiens

<400>  3101
agaagtatga aagagggtgg gcctgttgtc atgggggagg tggtggcgct tggtggccac     60

tggcggccga ggtagaggca gtggcgcttg agttggtcgg gggcagcggc agatttgagg    120

cttaagcaac ttcttccggg gaagagtgcc agtgcagcca ctgttacaat tcaagatctt    180

gatctatatc catagattgg aatattggtg ggccagcaat cctcagacgc ctcacttagg    240

acaaatgagg aaactgaggc ttggtgaagt tacgaaactt gtccaaaatc acacaacttg    300

taaagggcac agccaagatt cagagccagg ctgtaaaaat taaaatgaac aaattacggc    360

aaagttttag gagaaagaag gatgtttatg ttccagaggc cagtcgtcca catcagtggc    420

agacagatga agaaggcgtt cgcaccggaa aatgtagctt cccggttaag taccttggcc    480

atgtagaagt tgatgaatca agaggaatgc acatctgtga agatgctgta aaaagattga    540

aagctactgg aaagaaagca gttaaagcag ttctgtgggt ctcagcagat ggactcagag    600

ttgtggatga aaaaactaag gacctcatag ttgaccagac gatagagaaa gtttctttct    660

gtgccccaga caggaacttt gatagagcct tttcttacat atgccgtgat ggcaccactc    720

gtcgctggat ctgtcactgc ttcatggctg tcaaggacac aggtgaaagg ttgagccatg    780

cagtaggctg tgcttttgca gcctgtttag agcgcaagca gaagcgggag aaggaatgtg    840

gagtgactgc tacttttgat gctagtcgga ccacttttac aagagaagga tcattccgtg    900

tcacaacagc cactgaacaa gcagaaagag aggagatcat gaaacaaatg caagatgcca    960

agaaagctga aacagataag atagtcgttg gttcatcagt tgcccctggc aacactgccc   1020

catccccatc ctctcccacc tctcctactt ctgatgccac gacctctctg gagatgaaca   1080

atcctcatgc catcccacgc cggcatgctc caattgaaca gcttgctcgc caaggctctt   1140

tccgaggttt tcctgctctt agccagaaga tgtcaccctt taaacgccaa ctatccctac   1200

gcatcaatga gttgccttcc actatgcaga ggaagactga tttccccatt aaaaatgcag   1260

tgccagaagt agaaggggag gcagagagca tcagctccct gtgctcacag atcaccaatg   1320

ccttcagcac acctgaggac cccttctcat ctgctccgat gaccaaacca gtgacagtgg   1380

tggcaccaca atctcctacc ttccaagcta atggcactga ctcagccttc catgtgcttg   1440

ctaagccagc ccatactgct ctagcacccg tagcaatgcc tgtgcgtgaa accaaccctt   1500

gggcccatgc ccctgatgct gctaacaagg aaattgcagc cacatgttcg gggaccgagt   1560

ggggtcaatc ttctggtgct gcctctccag gtctcttcca ggccggtcat agacgtactc   1620

cctctgaggc cgaccgatgg ttagaagagg tgtctaagag cgtccgggct cagcagcccc   1680

aggcctcagc tgctcctctg cagccagttc tccagcctcc tccacccact gccatctccc   1740

agccagcatc acctttccaa gggaatgcat tcctcacctc tcagcctgtg ccagtgggtg   1800

tggtcccagc cctgcaacca gcctttgtcc ctgcccagtc ctatcctgtg gccaatggaa   1860

tgccctatcc agcccctaat gtgcctgtgg tgggcatcac tccctcccag atggtggcca   1920

acgtatttgg cactgcaggc caccctcagg ctgcccatcc ccatcagtca cccagcctgg   1980

tcaggcagca gacattccct cactacgagg caagcagtgc taccaccagt cccttcttta   2040

agcctcctgc tcagcacctc aacggttctg cagctttcaa tggtgtagat gatggcaggt   2100

tggcctcagc agacaggcat acagaggttc ctacaggcac ctgcccagtg gatccttttg   2160

aagcccagtg ggctgcatta gaaaataagt ccaagcagcg tactaatccc tcccctacca   2220

accctttctc cagtgactta cagaagacgt ttgaaattga actttaagca atcattatgg   2280

ctatgtatct tgtccatacc agacagggag cagggggtag cggtcaaagg agcaaaacag   2340

actttgtctc ctgattagta ctcttttcac taatcccaaa ggtcccaagg aacaagtcca   2400

ggcccagagt actgtgaggg gtgattttga aagacatggg aaaaagcatt cctagagaaa   2460

agctgccttg caattaggct aaagaagtca aggaaatgtt gctttctgta ctccctcttc   2520

ccttaccccc ttacaaatct ctggcaacag agaggcaaag tatctgaaca agaatctata   2580

ttccaagcac atttactgaa atgtaaaaca caacaggaag caaagcaatc tccctttgtt   2640

tttcaggcca ttcacctgcc tcctgtcagt agtggcctgt attagagatc aagaagagtg   2700

gtttgtgctc aggctgggga acagagaggc acgctatgct gccagaattc ccaggagggc   2760

atatcagcaa ctgcccagca gagctatatt ttgggggaga agttgagctt ccattttgag   2820

taacagaata aatattatat atatcaaaag ccaaaatctt tatttttatg catttagaat   2880

attttaaata gttctcagat attaagaagt tgtatgagtt gtaagtaatc ttgccaaagg   2940

taaaggggct agttgtaaga aattgtacat aagattgatt tatcattgat gcctactgaa   3000

ataaaaagag gaaaggctgg aagctgcaga caggatccct agcttgtttt ctgtcagtca   3060

ttcattgtaa gtagcacatt gcaacaacaa tcatgcttat gaccaataca gtcactaggt   3120

tgtagttttt tttaaataaa ggaaaagcag tattgtcctg gttttaaacc tatgatggaa   3180

ttctaatgtc attattttaa tggaatcaat cgaaatatgc tctatagaga atatatcttt   3240

tatatattgc tgcagtttcc ttatgttaat cctttaacac taaggtaaca tgacataatc   3300

ataccataga agggaacaca ggttaccata ttggtttgta atatgggtct tggtgggttt   3360

tgttttatcc tttaaatttt gttcccatga gttttgtggg gatggggatt ctggttttat   3420

tagctttgtg tgtgtcctct tcccccaaac ccccttttgg tgagaacatc cccttgacag   3480

ttgcagcctc ttgacctcgg ataacaataa gagagctcat ctcattttta cttttgaacg   3540

ttggccttac aatcaaatgt aagttatata tatttgtact gatgaaaatt tataatctgc   3600

tttaacaaaa ataaatgttc atggtagaag ct                                 3632


<210>  3102
<211>  640
<212>  PRT
<213>  Homo sapiens

<400>  3102


Met Asn Lys Leu Arg Gln Ser Phe Arg Arg Lys Lys Asp Val Tyr Val 
1               5                   10                  15      


Pro Glu Ala Ser Arg Pro His Gln Trp Gln Thr Asp Glu Glu Gly Val 
            20                  25                  30          


Arg Thr Gly Lys Cys Ser Phe Pro Val Lys Tyr Leu Gly His Val Glu 
        35                  40                  45              


Val Asp Glu Ser Arg Gly Met His Ile Cys Glu Asp Ala Val Lys Arg 
    50                  55                  60                  


Leu Lys Ala Thr Gly Lys Lys Ala Val Lys Ala Val Leu Trp Val Ser 
65                  70                  75                  80  


Ala Asp Gly Leu Arg Val Val Asp Glu Lys Thr Lys Asp Leu Ile Val 
                85                  90                  95      


Asp Gln Thr Ile Glu Lys Val Ser Phe Cys Ala Pro Asp Arg Asn Phe 
            100                 105                 110         


Asp Arg Ala Phe Ser Tyr Ile Cys Arg Asp Gly Thr Thr Arg Arg Trp 
        115                 120                 125             


Ile Cys His Cys Phe Met Ala Val Lys Asp Thr Gly Glu Arg Leu Ser 
    130                 135                 140                 


His Ala Val Gly Cys Ala Phe Ala Ala Cys Leu Glu Arg Lys Gln Lys 
145                 150                 155                 160 


Arg Glu Lys Glu Cys Gly Val Thr Ala Thr Phe Asp Ala Ser Arg Thr 
                165                 170                 175     


Thr Phe Thr Arg Glu Gly Ser Phe Arg Val Thr Thr Ala Thr Glu Gln 
            180                 185                 190         


Ala Glu Arg Glu Glu Ile Met Lys Gln Met Gln Asp Ala Lys Lys Ala 
        195                 200                 205             


Glu Thr Asp Lys Ile Val Val Gly Ser Ser Val Ala Pro Gly Asn Thr 
    210                 215                 220                 


Ala Pro Ser Pro Ser Ser Pro Thr Ser Pro Thr Ser Asp Ala Thr Thr 
225                 230                 235                 240 


Ser Leu Glu Met Asn Asn Pro His Ala Ile Pro Arg Arg His Ala Pro 
                245                 250                 255     


Ile Glu Gln Leu Ala Arg Gln Gly Ser Phe Arg Gly Phe Pro Ala Leu 
            260                 265                 270         


Ser Gln Lys Met Ser Pro Phe Lys Arg Gln Leu Ser Leu Arg Ile Asn 
        275                 280                 285             


Glu Leu Pro Ser Thr Met Gln Arg Lys Thr Asp Phe Pro Ile Lys Asn 
    290                 295                 300                 


Ala Val Pro Glu Val Glu Gly Glu Ala Glu Ser Ile Ser Ser Leu Cys 
305                 310                 315                 320 


Ser Gln Ile Thr Asn Ala Phe Ser Thr Pro Glu Asp Pro Phe Ser Ser 
                325                 330                 335     


Ala Pro Met Thr Lys Pro Val Thr Val Val Ala Pro Gln Ser Pro Thr 
            340                 345                 350         


Phe Gln Ala Asn Gly Thr Asp Ser Ala Phe His Val Leu Ala Lys Pro 
        355                 360                 365             


Ala His Thr Ala Leu Ala Pro Val Ala Met Pro Val Arg Glu Thr Asn 
    370                 375                 380                 


Pro Trp Ala His Ala Pro Asp Ala Ala Asn Lys Glu Ile Ala Ala Thr 
385                 390                 395                 400 


Cys Ser Gly Thr Glu Trp Gly Gln Ser Ser Gly Ala Ala Ser Pro Gly 
                405                 410                 415     


Leu Phe Gln Ala Gly His Arg Arg Thr Pro Ser Glu Ala Asp Arg Trp 
            420                 425                 430         


Leu Glu Glu Val Ser Lys Ser Val Arg Ala Gln Gln Pro Gln Ala Ser 
        435                 440                 445             


Ala Ala Pro Leu Gln Pro Val Leu Gln Pro Pro Pro Pro Thr Ala Ile 
    450                 455                 460                 


Ser Gln Pro Ala Ser Pro Phe Gln Gly Asn Ala Phe Leu Thr Ser Gln 
465                 470                 475                 480 


Pro Val Pro Val Gly Val Val Pro Ala Leu Gln Pro Ala Phe Val Pro 
                485                 490                 495     


Ala Gln Ser Tyr Pro Val Ala Asn Gly Met Pro Tyr Pro Ala Pro Asn 
            500                 505                 510         


Val Pro Val Val Gly Ile Thr Pro Ser Gln Met Val Ala Asn Val Phe 
        515                 520                 525             


Gly Thr Ala Gly His Pro Gln Ala Ala His Pro His Gln Ser Pro Ser 
    530                 535                 540                 


Leu Val Arg Gln Gln Thr Phe Pro His Tyr Glu Ala Ser Ser Ala Thr 
545                 550                 555                 560 


Thr Ser Pro Phe Phe Lys Pro Pro Ala Gln His Leu Asn Gly Ser Ala 
                565                 570                 575     


Ala Phe Asn Gly Val Asp Asp Gly Arg Leu Ala Ser Ala Asp Arg His 
            580                 585                 590         


Thr Glu Val Pro Thr Gly Thr Cys Pro Val Asp Pro Phe Glu Ala Gln 
        595                 600                 605             


Trp Ala Ala Leu Glu Asn Lys Ser Lys Gln Arg Thr Asn Pro Ser Pro 
    610                 615                 620                 


Thr Asn Pro Phe Ser Ser Asp Leu Gln Lys Thr Phe Glu Ile Glu Leu 
625                 630                 635                 640 

<210>  3103
<211>  3488
<212>  DNA
<213>  Homo sapiens

<400>  3103
agaagtatga aagagggtgg gcctgttgtc atgggggagg tggtggcgct tggtggccac     60

tggcggccga ggtagaggca gtggcgcttg agttggtcgg gggcagcggc agatttgagg    120

cttaagcaac ttcttccggg gaagagtgcc agtgcagcca ctgttacaat tcaagatctt    180

gatctatatc catagattgg aatattggtg ggccagcaat cctcagacgc ctcacttagg    240

acaaatgagg aaactgaggc ttggtgaagt tacgaaactt gtccaaaatc acacaacttg    300

taaagggcac agccaagatt cagagccagg ctgtaaaaat taaaatgaac aaattacggc    360

aaagttttag gagaaagaag gatgtttatg ttccagaggc cagtcgtcca catcagtggc    420

agacagatga agaaggcgtt cgcaccggaa aatgtagctt cccggttaag taccttggcc    480

atgtagaagt tgatgaatca agaggaatgc acatctgtga agatgctgta aaaagattga    540

aagctactgg aaagaaagca gttaaagcag ttctgtgggt ctcagcagat ggactcagag    600

ttgtggatga aaaaactaag gacctcatag ttgaccagac gatagagaaa gtttctttct    660

gtgccccaga caggaacttt gatagagcct tttcttacat atgccgtgat ggcaccactc    720

gtcgctggat ctgtcactgc ttcatggctg tcaaggacac aggtgaaagg ttgagccatg    780

cagtaggctg tgcttttgca gcctgtttag agcgcaagca gaagcgggag aaggaatgtg    840

gagtgactgc tacttttgat gctagtcgga ccacttttac aagagaagga tcattccgtg    900

tcacaacagc cactgaacaa gcagaaagag aggagatcat gaaacaaatg caagatgcca    960

agaaagctga aacagataag atagtcgttg gttcatcagt tgcccctggc aacactgccc   1020

catccccatc ctctcccacc tctcctactt ctgatgccac gacctctctg gagatgaaca   1080

atcctcatgc catcccacgc cggcatgctc caattgaaca gcttgctcgc caaggctctt   1140

tccgaggttt tcctgctctt agccagaaga tgtcaccctt taaacgccaa ctatccctac   1200

gcatcaatga gttgccttcc actatgcaga ggaagactga tttccccatt aaaaatgcag   1260

tgccagaagt agaaggggag gcagagagca tcagctccct gtgctcacag atcaccaatg   1320

ccttcagcac acctgaggac cccttctcat ctgctccgat gaccaaacca gtgacagtgg   1380

tggcaccaca atctcctacc ttccaaggga ccgagtgggg tcaatcttct ggtgctgcct   1440

ctccaggtct cttccaggcc ggtcatagac gtactccctc tgaggccgac cgatggttag   1500

aagaggtgtc taagagcgtc cgggctcagc agccccaggc ctcagctgct cctctgcagc   1560

cagttctcca gcctcctcca cccactgcca tctcccagcc agcatcacct ttccaaggga   1620

atgcattcct cacctctcag cctgtgccag tgggtgtggt cccagccctg caaccagcct   1680

ttgtccctgc ccagtcctat cctgtggcca atggaatgcc ctatccagcc cctaatgtgc   1740

ctgtggtggg catcactccc tcccagatgg tggccaacgt atttggcact gcaggccacc   1800

ctcaggctgc ccatccccat cagtcaccca gcctggtcag gcagcagaca ttccctcact   1860

acgaggcaag cagtgctacc accagtccct tctttaagcc tcctgctcag cacctcaacg   1920

gttctgcagc tttcaatggt gtagatgatg gcaggttggc ctcagcagac aggcatacag   1980

aggttcctac aggcacctgc ccagtggatc cttttgaagc ccagtgggct gcattagaaa   2040

ataagtccaa gcagcgtact aatccctccc ctaccaaccc tttctccagt gacttacaga   2100

agacgtttga aattgaactt taagcaatca ttatggctat gtatcttgtc cataccagac   2160

agggagcagg gggtagcggt caaaggagca aaacagactt tgtctcctga ttagtactct   2220

tttcactaat cccaaaggtc ccaaggaaca agtccaggcc cagagtactg tgaggggtga   2280

ttttgaaaga catgggaaaa agcattccta gagaaaagct gccttgcaat taggctaaag   2340

aagtcaagga aatgttgctt tctgtactcc ctcttccctt acccccttac aaatctctgg   2400

caacagagag gcaaagtatc tgaacaagaa tctatattcc aagcacattt actgaaatgt   2460

aaaacacaac aggaagcaaa gcaatctccc tttgtttttc aggccattca cctgcctcct   2520

gtcagtagtg gcctgtatta gagatcaaga agagtggttt gtgctcaggc tggggaacag   2580

agaggcacgc tatgctgcca gaattcccag gagggcatat cagcaactgc ccagcagagc   2640

tatattttgg gggagaagtt gagcttccat tttgagtaac agaataaata ttatatatat   2700

caaaagccaa aatctttatt tttatgcatt tagaatattt taaatagttc tcagatatta   2760

agaagttgta tgagttgtaa gtaatcttgc caaaggtaaa ggggctagtt gtaagaaatt   2820

gtacataaga ttgatttatc attgatgcct actgaaataa aaagaggaaa ggctggaagc   2880

tgcagacagg atccctagct tgttttctgt cagtcattca ttgtaagtag cacattgcaa   2940

caacaatcat gcttatgacc aatacagtca ctaggttgta gtttttttta aataaaggaa   3000

aagcagtatt gtcctggttt taaacctatg atggaattct aatgtcatta ttttaatgga   3060

atcaatcgaa atatgctcta tagagaatat atcttttata tattgctgca gtttccttat   3120

gttaatcctt taacactaag gtaacatgac ataatcatac catagaaggg aacacaggtt   3180

accatattgg tttgtaatat gggtcttggt gggttttgtt ttatccttta aattttgttc   3240

ccatgagttt tgtggggatg gggattctgg ttttattagc tttgtgtgtg tcctcttccc   3300

ccaaaccccc ttttggtgag aacatcccct tgacagttgc agcctcttga cctcggataa   3360

caataagaga gctcatctca tttttacttt tgaacgttgg ccttacaatc aaatgtaagt   3420

tatatatatt tgtactgatg aaaatttata atctgcttta acaaaaataa atgttcatgg   3480

tagaagct                                                            3488


<210>  3104
<211>  592
<212>  PRT
<213>  Homo sapiens

<400>  3104


Met Asn Lys Leu Arg Gln Ser Phe Arg Arg Lys Lys Asp Val Tyr Val 
1               5                   10                  15      


Pro Glu Ala Ser Arg Pro His Gln Trp Gln Thr Asp Glu Glu Gly Val 
            20                  25                  30          


Arg Thr Gly Lys Cys Ser Phe Pro Val Lys Tyr Leu Gly His Val Glu 
        35                  40                  45              


Val Asp Glu Ser Arg Gly Met His Ile Cys Glu Asp Ala Val Lys Arg 
    50                  55                  60                  


Leu Lys Ala Thr Gly Lys Lys Ala Val Lys Ala Val Leu Trp Val Ser 
65                  70                  75                  80  


Ala Asp Gly Leu Arg Val Val Asp Glu Lys Thr Lys Asp Leu Ile Val 
                85                  90                  95      


Asp Gln Thr Ile Glu Lys Val Ser Phe Cys Ala Pro Asp Arg Asn Phe 
            100                 105                 110         


Asp Arg Ala Phe Ser Tyr Ile Cys Arg Asp Gly Thr Thr Arg Arg Trp 
        115                 120                 125             


Ile Cys His Cys Phe Met Ala Val Lys Asp Thr Gly Glu Arg Leu Ser 
    130                 135                 140                 


His Ala Val Gly Cys Ala Phe Ala Ala Cys Leu Glu Arg Lys Gln Lys 
145                 150                 155                 160 


Arg Glu Lys Glu Cys Gly Val Thr Ala Thr Phe Asp Ala Ser Arg Thr 
                165                 170                 175     


Thr Phe Thr Arg Glu Gly Ser Phe Arg Val Thr Thr Ala Thr Glu Gln 
            180                 185                 190         


Ala Glu Arg Glu Glu Ile Met Lys Gln Met Gln Asp Ala Lys Lys Ala 
        195                 200                 205             


Glu Thr Asp Lys Ile Val Val Gly Ser Ser Val Ala Pro Gly Asn Thr 
    210                 215                 220                 


Ala Pro Ser Pro Ser Ser Pro Thr Ser Pro Thr Ser Asp Ala Thr Thr 
225                 230                 235                 240 


Ser Leu Glu Met Asn Asn Pro His Ala Ile Pro Arg Arg His Ala Pro 
                245                 250                 255     


Ile Glu Gln Leu Ala Arg Gln Gly Ser Phe Arg Gly Phe Pro Ala Leu 
            260                 265                 270         


Ser Gln Lys Met Ser Pro Phe Lys Arg Gln Leu Ser Leu Arg Ile Asn 
        275                 280                 285             


Glu Leu Pro Ser Thr Met Gln Arg Lys Thr Asp Phe Pro Ile Lys Asn 
    290                 295                 300                 


Ala Val Pro Glu Val Glu Gly Glu Ala Glu Ser Ile Ser Ser Leu Cys 
305                 310                 315                 320 


Ser Gln Ile Thr Asn Ala Phe Ser Thr Pro Glu Asp Pro Phe Ser Ser 
                325                 330                 335     


Ala Pro Met Thr Lys Pro Val Thr Val Val Ala Pro Gln Ser Pro Thr 
            340                 345                 350         


Phe Gln Gly Thr Glu Trp Gly Gln Ser Ser Gly Ala Ala Ser Pro Gly 
        355                 360                 365             


Leu Phe Gln Ala Gly His Arg Arg Thr Pro Ser Glu Ala Asp Arg Trp 
    370                 375                 380                 


Leu Glu Glu Val Ser Lys Ser Val Arg Ala Gln Gln Pro Gln Ala Ser 
385                 390                 395                 400 


Ala Ala Pro Leu Gln Pro Val Leu Gln Pro Pro Pro Pro Thr Ala Ile 
                405                 410                 415     


Ser Gln Pro Ala Ser Pro Phe Gln Gly Asn Ala Phe Leu Thr Ser Gln 
            420                 425                 430         


Pro Val Pro Val Gly Val Val Pro Ala Leu Gln Pro Ala Phe Val Pro 
        435                 440                 445             


Ala Gln Ser Tyr Pro Val Ala Asn Gly Met Pro Tyr Pro Ala Pro Asn 
    450                 455                 460                 


Val Pro Val Val Gly Ile Thr Pro Ser Gln Met Val Ala Asn Val Phe 
465                 470                 475                 480 


Gly Thr Ala Gly His Pro Gln Ala Ala His Pro His Gln Ser Pro Ser 
                485                 490                 495     


Leu Val Arg Gln Gln Thr Phe Pro His Tyr Glu Ala Ser Ser Ala Thr 
            500                 505                 510         


Thr Ser Pro Phe Phe Lys Pro Pro Ala Gln His Leu Asn Gly Ser Ala 
        515                 520                 525             


Ala Phe Asn Gly Val Asp Asp Gly Arg Leu Ala Ser Ala Asp Arg His 
    530                 535                 540                 


Thr Glu Val Pro Thr Gly Thr Cys Pro Val Asp Pro Phe Glu Ala Gln 
545                 550                 555                 560 


Trp Ala Ala Leu Glu Asn Lys Ser Lys Gln Arg Thr Asn Pro Ser Pro 
                565                 570                 575     


Thr Asn Pro Phe Ser Ser Asp Leu Gln Lys Thr Phe Glu Ile Glu Leu 
            580                 585                 590         

<210>  3105
<211>  3665
<212>  DNA
<213>  Homo sapiens

<400>  3105
agaagtatga aagagggtgg gcctgttgtc atgggggagg tggtggcgct tggtggccac     60

tggcggccga ggtagaggca gtggcgcttg agttggtcgg gggcagcggc agatttgagg    120

cttaagcaac ttcttccggg gaagagtgcc agtgcagcca ctgttacaat tcaagatctt    180

gatctatatc catagattgg aatattggtg ggccagcaat cctcagacgc ctcacttagg    240

acaaatgagg aaactgaggc ttggtgaagt tacgaaactt gtccaaaatc acacaacttg    300

taaagggcac agccaagatt cagagccagg ctgtaaaaat taaaatgaac aaattacggc    360

aaagttttag gagaaagaag gatgtttatg ttccagaggc cagtcgtcca catcagtggc    420

agacagatga agaaggcgtt cgcaccggaa aatgtagctt cccggttaag taccttggcc    480

atgtagaagt tgatgaatca agaggaatgc acatctgtga agatgctgta aaaagattga    540

aagctgaaag gaagttcttc aaaggcttct ttggaaaaac tggaaagaaa gcagttaaag    600

cagttctgtg ggtctcagca gatggactca gagttgtgga tgaaaaaact aaggacctca    660

tagttgacca gacgatagag aaagtttctt tctgtgcccc agacaggaac tttgatagag    720

ccttttctta catatgccgt gatggcacca ctcgtcgctg gatctgtcac tgcttcatgg    780

ctgtcaagga cacaggtgaa aggttgagcc atgcagtagg ctgtgctttt gcagcctgtt    840

tagagcgcaa gcagaagcgg gagaaggaat gtggagtgac tgctactttt gatgctagtc    900

ggaccacttt tacaagagaa ggatcattcc gtgtcacaac agccactgaa caagcagaaa    960

gagaggagat catgaaacaa atgcaagatg ccaagaaagc tgaaacagat aagatagtcg   1020

ttggttcatc agttgcccct ggcaacactg ccccatcccc atcctctccc acctctccta   1080

cttctgatgc cacgacctct ctggagatga acaatcctca tgccatccca cgccggcatg   1140

ctccaattga acagcttgct cgccaaggct ctttccgagg ttttcctgct cttagccaga   1200

agatgtcacc ctttaaacgc caactatccc tacgcatcaa tgagttgcct tccactatgc   1260

agaggaagac tgatttcccc attaaaaatg cagtgccaga agtagaaggg gaggcagaga   1320

gcatcagctc cctgtgctca cagatcacca atgccttcag cacacctgag gaccccttct   1380

catctgctcc gatgaccaaa ccagtgacag tggtggcacc acaatctcct accttccaag   1440

ctaatggcac tgactcagcc ttccatgtgc ttgctaagcc agcccatact gctctagcac   1500

ccgtagcaat gcctgtgcgt gaaaccaacc cttgggccca tgcccctgat gctgctaaca   1560

aggaaattgc agccacatgt tcggggaccg agtggggtca atcttctggt gctgcctctc   1620

caggtctctt ccaggccggt catagacgta ctccctctga ggccgaccga tggttagaag   1680

aggtgtctaa gagcgtccgg gctcagcagc cccaggcctc agctgctcct ctgcagccag   1740

ttctccagcc tcctccaccc actgccatct cccagccagc atcacctttc caagggaatg   1800

cattcctcac ctctcagcct gtgccagtgg gtgtggtccc agccctgcaa ccagcctttg   1860

tccctgccca gtcctatcct gtggccaatg gaatgcccta tccagcccct aatgtgcctg   1920

tggtgggcat cactccctcc cagatggtgg ccaacgtatt tggcactgca ggccaccctc   1980

aggctgccca tccccatcag tcacccagcc tggtcaggca gcagacattc cctcactacg   2040

aggcaagcag tgctaccacc agtcccttct ttaagcctcc tgctcagcac ctcaacggtt   2100

ctgcagcttt caatggtgta gatgatggca ggttggcctc agcagacagg catacagagg   2160

ttcctacagg cacctgccca gtggatcctt ttgaagccca gtgggctgca ttagaaaata   2220

agtccaagca gcgtactaat ccctccccta ccaacccttt ctccagtgac ttacagaaga   2280

cgtttgaaat tgaactttaa gcaatcatta tggctatgta tcttgtccat accagacagg   2340

gagcaggggg tagcggtcaa aggagcaaaa cagactttgt ctcctgatta gtactctttt   2400

cactaatccc aaaggtccca aggaacaagt ccaggcccag agtactgtga ggggtgattt   2460

tgaaagacat gggaaaaagc attcctagag aaaagctgcc ttgcaattag gctaaagaag   2520

tcaaggaaat gttgctttct gtactccctc ttcccttacc cccttacaaa tctctggcaa   2580

cagagaggca aagtatctga acaagaatct atattccaag cacatttact gaaatgtaaa   2640

acacaacagg aagcaaagca atctcccttt gtttttcagg ccattcacct gcctcctgtc   2700

agtagtggcc tgtattagag atcaagaaga gtggtttgtg ctcaggctgg ggaacagaga   2760

ggcacgctat gctgccagaa ttcccaggag ggcatatcag caactgccca gcagagctat   2820

attttggggg agaagttgag cttccatttt gagtaacaga ataaatatta tatatatcaa   2880

aagccaaaat ctttattttt atgcatttag aatattttaa atagttctca gatattaaga   2940

agttgtatga gttgtaagta atcttgccaa aggtaaaggg gctagttgta agaaattgta   3000

cataagattg atttatcatt gatgcctact gaaataaaaa gaggaaaggc tggaagctgc   3060

agacaggatc cctagcttgt tttctgtcag tcattcattg taagtagcac attgcaacaa   3120

caatcatgct tatgaccaat acagtcacta ggttgtagtt ttttttaaat aaaggaaaag   3180

cagtattgtc ctggttttaa acctatgatg gaattctaat gtcattattt taatggaatc   3240

aatcgaaata tgctctatag agaatatatc ttttatatat tgctgcagtt tccttatgtt   3300

aatcctttaa cactaaggta acatgacata atcataccat agaagggaac acaggttacc   3360

atattggttt gtaatatggg tcttggtggg ttttgtttta tcctttaaat tttgttccca   3420

tgagttttgt ggggatgggg attctggttt tattagcttt gtgtgtgtcc tcttccccca   3480

aacccccttt tggtgagaac atccccttga cagttgcagc ctcttgacct cggataacaa   3540

taagagagct catctcattt ttacttttga acgttggcct tacaatcaaa tgtaagttat   3600

atatatttgt actgatgaaa atttataatc tgctttaaca aaaataaatg ttcatggtag   3660

aagct                                                               3665


<210>  3106
<211>  651
<212>  PRT
<213>  Homo sapiens

<400>  3106


Met Asn Lys Leu Arg Gln Ser Phe Arg Arg Lys Lys Asp Val Tyr Val 
1               5                   10                  15      


Pro Glu Ala Ser Arg Pro His Gln Trp Gln Thr Asp Glu Glu Gly Val 
            20                  25                  30          


Arg Thr Gly Lys Cys Ser Phe Pro Val Lys Tyr Leu Gly His Val Glu 
        35                  40                  45              


Val Asp Glu Ser Arg Gly Met His Ile Cys Glu Asp Ala Val Lys Arg 
    50                  55                  60                  


Leu Lys Ala Glu Arg Lys Phe Phe Lys Gly Phe Phe Gly Lys Thr Gly 
65                  70                  75                  80  


Lys Lys Ala Val Lys Ala Val Leu Trp Val Ser Ala Asp Gly Leu Arg 
                85                  90                  95      


Val Val Asp Glu Lys Thr Lys Asp Leu Ile Val Asp Gln Thr Ile Glu 
            100                 105                 110         


Lys Val Ser Phe Cys Ala Pro Asp Arg Asn Phe Asp Arg Ala Phe Ser 
        115                 120                 125             


Tyr Ile Cys Arg Asp Gly Thr Thr Arg Arg Trp Ile Cys His Cys Phe 
    130                 135                 140                 


Met Ala Val Lys Asp Thr Gly Glu Arg Leu Ser His Ala Val Gly Cys 
145                 150                 155                 160 


Ala Phe Ala Ala Cys Leu Glu Arg Lys Gln Lys Arg Glu Lys Glu Cys 
                165                 170                 175     


Gly Val Thr Ala Thr Phe Asp Ala Ser Arg Thr Thr Phe Thr Arg Glu 
            180                 185                 190         


Gly Ser Phe Arg Val Thr Thr Ala Thr Glu Gln Ala Glu Arg Glu Glu 
        195                 200                 205             


Ile Met Lys Gln Met Gln Asp Ala Lys Lys Ala Glu Thr Asp Lys Ile 
    210                 215                 220                 


Val Val Gly Ser Ser Val Ala Pro Gly Asn Thr Ala Pro Ser Pro Ser 
225                 230                 235                 240 


Ser Pro Thr Ser Pro Thr Ser Asp Ala Thr Thr Ser Leu Glu Met Asn 
                245                 250                 255     


Asn Pro His Ala Ile Pro Arg Arg His Ala Pro Ile Glu Gln Leu Ala 
            260                 265                 270         


Arg Gln Gly Ser Phe Arg Gly Phe Pro Ala Leu Ser Gln Lys Met Ser 
        275                 280                 285             


Pro Phe Lys Arg Gln Leu Ser Leu Arg Ile Asn Glu Leu Pro Ser Thr 
    290                 295                 300                 


Met Gln Arg Lys Thr Asp Phe Pro Ile Lys Asn Ala Val Pro Glu Val 
305                 310                 315                 320 


Glu Gly Glu Ala Glu Ser Ile Ser Ser Leu Cys Ser Gln Ile Thr Asn 
                325                 330                 335     


Ala Phe Ser Thr Pro Glu Asp Pro Phe Ser Ser Ala Pro Met Thr Lys 
            340                 345                 350         


Pro Val Thr Val Val Ala Pro Gln Ser Pro Thr Phe Gln Ala Asn Gly 
        355                 360                 365             


Thr Asp Ser Ala Phe His Val Leu Ala Lys Pro Ala His Thr Ala Leu 
    370                 375                 380                 


Ala Pro Val Ala Met Pro Val Arg Glu Thr Asn Pro Trp Ala His Ala 
385                 390                 395                 400 


Pro Asp Ala Ala Asn Lys Glu Ile Ala Ala Thr Cys Ser Gly Thr Glu 
                405                 410                 415     


Trp Gly Gln Ser Ser Gly Ala Ala Ser Pro Gly Leu Phe Gln Ala Gly 
            420                 425                 430         


His Arg Arg Thr Pro Ser Glu Ala Asp Arg Trp Leu Glu Glu Val Ser 
        435                 440                 445             


Lys Ser Val Arg Ala Gln Gln Pro Gln Ala Ser Ala Ala Pro Leu Gln 
    450                 455                 460                 


Pro Val Leu Gln Pro Pro Pro Pro Thr Ala Ile Ser Gln Pro Ala Ser 
465                 470                 475                 480 


Pro Phe Gln Gly Asn Ala Phe Leu Thr Ser Gln Pro Val Pro Val Gly 
                485                 490                 495     


Val Val Pro Ala Leu Gln Pro Ala Phe Val Pro Ala Gln Ser Tyr Pro 
            500                 505                 510         


Val Ala Asn Gly Met Pro Tyr Pro Ala Pro Asn Val Pro Val Val Gly 
        515                 520                 525             


Ile Thr Pro Ser Gln Met Val Ala Asn Val Phe Gly Thr Ala Gly His 
    530                 535                 540                 


Pro Gln Ala Ala His Pro His Gln Ser Pro Ser Leu Val Arg Gln Gln 
545                 550                 555                 560 


Thr Phe Pro His Tyr Glu Ala Ser Ser Ala Thr Thr Ser Pro Phe Phe 
                565                 570                 575     


Lys Pro Pro Ala Gln His Leu Asn Gly Ser Ala Ala Phe Asn Gly Val 
            580                 585                 590         


Asp Asp Gly Arg Leu Ala Ser Ala Asp Arg His Thr Glu Val Pro Thr 
        595                 600                 605             


Gly Thr Cys Pro Val Asp Pro Phe Glu Ala Gln Trp Ala Ala Leu Glu 
    610                 615                 620                 


Asn Lys Ser Lys Gln Arg Thr Asn Pro Ser Pro Thr Asn Pro Phe Ser 
625                 630                 635                 640 


Ser Asp Leu Gln Lys Thr Phe Glu Ile Glu Leu 
                645                 650     

<210>  3107
<211>  2771
<212>  DNA
<213>  Homo sapiens

<400>  3107
ctgttgtcat gggggaggtg gtggcgcttg gtggccactg gcggccgagg tagaggcagt     60

ggcgcttgag ttggtcgggg gcagcggcag atttgaggct taagcaactt cttccgggga    120

agagtgccag tgcagccact gttacaattc aagatcttga tctatatcca tagattggaa    180

tattggtggg ccagcaatcc tcagacgcct cacttaggac aagctgtaaa aattaaaatg    240

aacaaattac ggcaaagttt taggagaaag aaggatgttt atgttccaga ggccagtcgt    300

ccacatcagt ggcagacaga tgaagaaggc gttcgcaccg gaaaatgtag cttcccggtt    360

aagtaccttg gccatgtaga agttgatgaa tcaagaggaa tgcacatctg tgaagatgct    420

gtaaaaagat tgaaagctga aaggaagttc ttcaaaggct tctttggaaa aactggaaag    480

aaagcagtta aagcagttct gtgggtctca gcagatggac tcagagttgt ggatgaaaaa    540

actaaggacc tcatagttga ccagacgata gagaaagttt ctttctgtgc cccagacagg    600

aactttgata gagccttttc ttacatatgc cgtgatggca ccactcgtcg ctggatctgt    660

cactgcttca tggctgtcaa ggacacaggt gaaaggttga gccatgcagt aggctgtgct    720

tttgcagcct gtttagagcg caagcagaag cgggagaagg aatgtggagt gactgctact    780

tttgatgcta gtcggaccac ttttacaaga gaaggatcat tccgtgtcac aacagccact    840

gaacaagcag aaagagagga gatcatgaaa caaatgcaag atgccaagaa agctgaaaca    900

gataagatag tcgttggttc atcagttgcc cctggcaaca ctgccccatc cccatcctct    960

cccacctctc ctacttctga tgccacgacc tctctggaga tgaacaatcc tcatgccatc   1020

ccacgccggc atgctccaat tgaacagctt gctcgccaag gctctttccg aggttttcct   1080

gctcttagcc agaagatgtc accctttaaa cgccaactat ccctacgcat caatgagttg   1140

ccttccacta tgcagaggaa gactgatttc cccattaaaa atgcagtgcc agaagtagaa   1200

ggggaggcag agagcatcag ctccctgtgc tcacagatca ccaatgcctt cagcacacct   1260

gaggacccct tctcatctgc tccgatgacc aaaccagtga cagtggtggc accacaatct   1320

cctaccttcc aagctaatgg cactgactca gccttccatg tgcttgctaa gccagcccat   1380

actgctctag cacccgtagc aatgcctgtg cgtgaaacca acccttgggc ccatgcccct   1440

gatgctgcta acaaggaaat tgcagccaca tgttcgggga ccgagtgggg tcaatcttct   1500

ggtgctgcct ctccaggtct cttccaggcc ggtcatagac gtactccctc tgaggccgac   1560

cgatggttag aagaggtgtc taagagcgtc cgggctcagc agccccaggc ctcagctgct   1620

cctctgcagc cagttctcca gcctcctcca cccactgcca tctcccagcc agcatcacct   1680

ttccaaggga atgcattcct cacctctcag cctgtgccag tgggtgtggt cccagccctg   1740

caaccagcct ttgtccctgc ccagtcctat cctgtggcca atggaatgcc ctatccagcc   1800

cctaatgtgc ctgtggtggg catcactccc tcccagatgg tggccaacgt atttggcact   1860

gcaggccacc ctcaggctgc ccatccccat cagtcaccca gcctggtcag gcagcagaca   1920

ttccctcact acgaggcaag cagtgctacc accagtccct tctttaagcc tcctgctcag   1980

cacctcaacg gttctgcagc tttcaatggt gtagatgatg gcaggttggc ctcagcagac   2040

aggcatacag aggttcctac aggcacctgc ccagtggatc cttttgaagc ccagtgggct   2100

gcattagaaa ataagtccaa gcagcgtact aatccctccc ctaccaaccc tttctccagt   2160

gacttacaga agacgtttga aattgaactt taagcaatca ttatggctat gtatcttgtc   2220

cataccagac agggagcagg gggtagcggt caaaggagca aaacagactt tgtctcctga   2280

ttagtactct tttcactaat cccaaaggtc ccaaggaaca agtccaggcc cagagtactg   2340

tgaggggtga ttttgaaaga catgggaaaa agcattccta gagaaaagct gccttgcaat   2400

taggctaaag aagtcaagga aatgttgctt tctgtactcc ctcttccctt acccccttac   2460

aaatctctgg caacagagag gcaaagtatc tgaacaagaa tctatattcc aagcacattt   2520

actgaaatgt aaaacacaac aggaagcaaa gcaatctccc tttgtttttc aggccattca   2580

cctgcctcct gtcagtagtg gcctgtatta gagatcaaga agagtggttt gtgctcaggc   2640

tggggaacag agaggcacgc tatgctgcca gaattcccag gagggcatat cagcaactgc   2700

ccagcagagc tatattttgg gggagaagtt gagcttccat tttgagtaac agaataaata   2760

ttatatatat c                                                        2771


<210>  3108
<211>  651
<212>  PRT
<213>  Homo sapiens

<400>  3108


Met Asn Lys Leu Arg Gln Ser Phe Arg Arg Lys Lys Asp Val Tyr Val 
1               5                   10                  15      


Pro Glu Ala Ser Arg Pro His Gln Trp Gln Thr Asp Glu Glu Gly Val 
            20                  25                  30          


Arg Thr Gly Lys Cys Ser Phe Pro Val Lys Tyr Leu Gly His Val Glu 
        35                  40                  45              


Val Asp Glu Ser Arg Gly Met His Ile Cys Glu Asp Ala Val Lys Arg 
    50                  55                  60                  


Leu Lys Ala Glu Arg Lys Phe Phe Lys Gly Phe Phe Gly Lys Thr Gly 
65                  70                  75                  80  


Lys Lys Ala Val Lys Ala Val Leu Trp Val Ser Ala Asp Gly Leu Arg 
                85                  90                  95      


Val Val Asp Glu Lys Thr Lys Asp Leu Ile Val Asp Gln Thr Ile Glu 
            100                 105                 110         


Lys Val Ser Phe Cys Ala Pro Asp Arg Asn Phe Asp Arg Ala Phe Ser 
        115                 120                 125             


Tyr Ile Cys Arg Asp Gly Thr Thr Arg Arg Trp Ile Cys His Cys Phe 
    130                 135                 140                 


Met Ala Val Lys Asp Thr Gly Glu Arg Leu Ser His Ala Val Gly Cys 
145                 150                 155                 160 


Ala Phe Ala Ala Cys Leu Glu Arg Lys Gln Lys Arg Glu Lys Glu Cys 
                165                 170                 175     


Gly Val Thr Ala Thr Phe Asp Ala Ser Arg Thr Thr Phe Thr Arg Glu 
            180                 185                 190         


Gly Ser Phe Arg Val Thr Thr Ala Thr Glu Gln Ala Glu Arg Glu Glu 
        195                 200                 205             


Ile Met Lys Gln Met Gln Asp Ala Lys Lys Ala Glu Thr Asp Lys Ile 
    210                 215                 220                 


Val Val Gly Ser Ser Val Ala Pro Gly Asn Thr Ala Pro Ser Pro Ser 
225                 230                 235                 240 


Ser Pro Thr Ser Pro Thr Ser Asp Ala Thr Thr Ser Leu Glu Met Asn 
                245                 250                 255     


Asn Pro His Ala Ile Pro Arg Arg His Ala Pro Ile Glu Gln Leu Ala 
            260                 265                 270         


Arg Gln Gly Ser Phe Arg Gly Phe Pro Ala Leu Ser Gln Lys Met Ser 
        275                 280                 285             


Pro Phe Lys Arg Gln Leu Ser Leu Arg Ile Asn Glu Leu Pro Ser Thr 
    290                 295                 300                 


Met Gln Arg Lys Thr Asp Phe Pro Ile Lys Asn Ala Val Pro Glu Val 
305                 310                 315                 320 


Glu Gly Glu Ala Glu Ser Ile Ser Ser Leu Cys Ser Gln Ile Thr Asn 
                325                 330                 335     


Ala Phe Ser Thr Pro Glu Asp Pro Phe Ser Ser Ala Pro Met Thr Lys 
            340                 345                 350         


Pro Val Thr Val Val Ala Pro Gln Ser Pro Thr Phe Gln Ala Asn Gly 
        355                 360                 365             


Thr Asp Ser Ala Phe His Val Leu Ala Lys Pro Ala His Thr Ala Leu 
    370                 375                 380                 


Ala Pro Val Ala Met Pro Val Arg Glu Thr Asn Pro Trp Ala His Ala 
385                 390                 395                 400 


Pro Asp Ala Ala Asn Lys Glu Ile Ala Ala Thr Cys Ser Gly Thr Glu 
                405                 410                 415     


Trp Gly Gln Ser Ser Gly Ala Ala Ser Pro Gly Leu Phe Gln Ala Gly 
            420                 425                 430         


His Arg Arg Thr Pro Ser Glu Ala Asp Arg Trp Leu Glu Glu Val Ser 
        435                 440                 445             


Lys Ser Val Arg Ala Gln Gln Pro Gln Ala Ser Ala Ala Pro Leu Gln 
    450                 455                 460                 


Pro Val Leu Gln Pro Pro Pro Pro Thr Ala Ile Ser Gln Pro Ala Ser 
465                 470                 475                 480 


Pro Phe Gln Gly Asn Ala Phe Leu Thr Ser Gln Pro Val Pro Val Gly 
                485                 490                 495     


Val Val Pro Ala Leu Gln Pro Ala Phe Val Pro Ala Gln Ser Tyr Pro 
            500                 505                 510         


Val Ala Asn Gly Met Pro Tyr Pro Ala Pro Asn Val Pro Val Val Gly 
        515                 520                 525             


Ile Thr Pro Ser Gln Met Val Ala Asn Val Phe Gly Thr Ala Gly His 
    530                 535                 540                 


Pro Gln Ala Ala His Pro His Gln Ser Pro Ser Leu Val Arg Gln Gln 
545                 550                 555                 560 


Thr Phe Pro His Tyr Glu Ala Ser Ser Ala Thr Thr Ser Pro Phe Phe 
                565                 570                 575     


Lys Pro Pro Ala Gln His Leu Asn Gly Ser Ala Ala Phe Asn Gly Val 
            580                 585                 590         


Asp Asp Gly Arg Leu Ala Ser Ala Asp Arg His Thr Glu Val Pro Thr 
        595                 600                 605             


Gly Thr Cys Pro Val Asp Pro Phe Glu Ala Gln Trp Ala Ala Leu Glu 
    610                 615                 620                 


Asn Lys Ser Lys Gln Arg Thr Asn Pro Ser Pro Thr Asn Pro Phe Ser 
625                 630                 635                 640 


Ser Asp Leu Gln Lys Thr Phe Glu Ile Glu Leu 
                645                 650     

<210>  3109
<211>  2049
<212>  DNA
<213>  Homo sapiens

<400>  3109
ctgttgtcat gggggaggtg gtggcgcttg gtggccactg gcggccgagg tagaggcagt     60

ggcgcttgag ttggtcgggg gcagcggcag atttgaggct taagcaactt cttccgggga    120

agagtgccag tgcagccact gttacaattc aagatcttga tctatatcca tagattggaa    180

tattggtggg ccagcaatcc tcagacgcct cacttaggac aagctgtaaa aattaaaatg    240

aacaaattac ggcaaagttt taggagaaag aaggatgttt atgttccaga ggccagtcgt    300

ccacatcagt ggcagacaga tgaagaaggc gttcgcaccg gaaaatgtag cttcccggtt    360

aagtaccttg gccatgtaga agttgatgaa tcaagaggaa tgcacatctg tgaagatgct    420

gtaaaaagat tgaaagctac tggaaagaaa gcagttaaag cagttctgtg ggtctcagca    480

gatggactca gagttgtgga tgaaaaaact aaggacctca tagttgacca gacgatagag    540

aaagtttctt tctgtgcccc agacaggaac tttgatagag ccttttctta catatgccgt    600

gatggcacca ctcgtcgctg gatctgtcac tgcttcatgg ctgtcaagga cacaggtgaa    660

aggttgagcc atgcagtagg ctgtgctttt gcagcctgtt tagagcgcaa gcagaagcgg    720

gagaaggaat gtggagtgac tgctactttt gatgctagtc ggaccacttt tacaagagaa    780

ggatcattcc gtgtcacaac agccactgaa caagcagaaa gagaggagat catgaaacaa    840

atgcaagatg ccaagaaagg tacaatctgt tctacagtgt gtatttatgg aatgcagttt    900

ttcccaacaa ggtattattt tgaagctacc aggggtaaat tttctcataa tcaaagagaa    960

cccttagcaa tataaaacct tataacaaag ttgaaaatct taaaaaccgc ttcctttaga   1020

gtggctagtt taatggcttc aaaaatattt actccattat agtaagctat ctgaggaatc   1080

agagtgcagt tgaagaagct gcagagacat ctcttacccc cttcctccca tcctgaaata   1140

cctttttaat tctgatgtat ctgatctctt tgagaagcaa atgaatcaag tacctgcatc   1200

ttaaaggaag cagcagaggt cccagggctt aaggctgcaa agcatccacg gactatgatg   1260

ctagcagaga gatttaacag taatactgtt tatatgatat tattgctgtt ttttagtgct   1320

ttctagtcac aaaagtctat agattttgag aggtaagcct ataactcttt ttttctatag   1380

ccctgttaat ttaatttagt gtgtgatttt atagagtgtg agttttattt aggtacacat   1440

ggcatcacag cagaaatgcc tgtacaaaca ttcaagttag ttggcagtct ataaatgtga   1500

gttgggtata ttttacaact aaatgatagg gcttgaaaat acttttgaat tcttgtatat   1560

aagtagggtt aaaaccaaca agacaagcac aaacaattca agttaactaa tagacattaa   1620

tataattttg aggccaggta tagtggctta cagctgtaat ctcaatactt taggaggctg   1680

aggaggaaac atcacttgag gccaggagtt tgtgaccaga ctgtgcaaca tagactctat   1740

cccttaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaatt gccatatttg gtggtgcaca   1800

tccgtaatcc tagctgcttg ggaggctgag accagaggat tgctggagcc caggagtaca   1860

aggttacagt gagctgtgat cataccactg cactcctcca gcctgggtaa cagcaaaacc   1920

ctgtctctta aaaacaaaca aatatatata tatgataatt ttttttacta taacctttta   1980

gttctaaact agtcattttt gttgttgttg ttttggtttg atttcggtgt tttttttttt   2040

tttgagaca                                                           2049


<210>  3110
<211>  245
<212>  PRT
<213>  Homo sapiens

<400>  3110


Met Asn Lys Leu Arg Gln Ser Phe Arg Arg Lys Lys Asp Val Tyr Val 
1               5                   10                  15      


Pro Glu Ala Ser Arg Pro His Gln Trp Gln Thr Asp Glu Glu Gly Val 
            20                  25                  30          


Arg Thr Gly Lys Cys Ser Phe Pro Val Lys Tyr Leu Gly His Val Glu 
        35                  40                  45              


Val Asp Glu Ser Arg Gly Met His Ile Cys Glu Asp Ala Val Lys Arg 
    50                  55                  60                  


Leu Lys Ala Thr Gly Lys Lys Ala Val Lys Ala Val Leu Trp Val Ser 
65                  70                  75                  80  


Ala Asp Gly Leu Arg Val Val Asp Glu Lys Thr Lys Asp Leu Ile Val 
                85                  90                  95      


Asp Gln Thr Ile Glu Lys Val Ser Phe Cys Ala Pro Asp Arg Asn Phe 
            100                 105                 110         


Asp Arg Ala Phe Ser Tyr Ile Cys Arg Asp Gly Thr Thr Arg Arg Trp 
        115                 120                 125             


Ile Cys His Cys Phe Met Ala Val Lys Asp Thr Gly Glu Arg Leu Ser 
    130                 135                 140                 


His Ala Val Gly Cys Ala Phe Ala Ala Cys Leu Glu Arg Lys Gln Lys 
145                 150                 155                 160 


Arg Glu Lys Glu Cys Gly Val Thr Ala Thr Phe Asp Ala Ser Arg Thr 
                165                 170                 175     


Thr Phe Thr Arg Glu Gly Ser Phe Arg Val Thr Thr Ala Thr Glu Gln 
            180                 185                 190         


Ala Glu Arg Glu Glu Ile Met Lys Gln Met Gln Asp Ala Lys Lys Gly 
        195                 200                 205             


Thr Ile Cys Ser Thr Val Cys Ile Tyr Gly Met Gln Phe Phe Pro Thr 
    210                 215                 220                 


Arg Tyr Tyr Phe Glu Ala Thr Arg Gly Lys Phe Ser His Asn Gln Arg 
225                 230                 235                 240 


Glu Pro Leu Ala Ile 
                245 

<210>  3111
<211>  2156
<212>  DNA
<213>  Homo sapiens

<400>  3111
agaagtatga aagagggtgg gcctgttgtc atgggggagg tggtggcgct tggtggccac     60

tggcggccga ggtagaggca gtggcgcttg agttggtcgg gggcagcggc agatttgagg    120

cttaagcaac ttcttccggg gaagagtgcc agtgcagcca ctgttacaat tcaagatctt    180

gatctatatc catagattgg aatattggtg ggccagcaat cctcagacgc ctcacttagg    240

acaaatgagg aaactgaggc ttggtgaagt tacgaaactt gtccaaaatc acacaacttg    300

taaagggcac agccaagatt cagagccagg ctgtaaaaat taaaatgaac aaattacggc    360

aaagttttag gagaaagaag gatgtttatg ttccagaggc cagtcgtcca catcagtggc    420

agacagatga agaaggcgtt cgcaccggaa aatgtagctt cccggttaag taccttggcc    480

atgtagaagt tgatgaatca agaggaatgc acatctgtga agatgctgta aaaagattga    540

aagctactgg aaagaaagca gttaaagcag ttctgtgggt ctcagcagat ggactcagag    600

ttgtggatga aaaaactaag gacctcatag ttgaccagac gatagagaaa gtttctttct    660

gtgccccaga caggaacttt gatagagcct tttcttacat atgccgtgat ggcaccactc    720

gtcgctggat ctgtcactgc ttcatggctg tcaaggacac aggtgaaagg ttgagccatg    780

cagtaggctg tgcttttgca gcctgtttag agcgcaagca gaagcgggag aaggaatgtg    840

gagtgactgc tacttttgat gctagtcgga ccacttttac aagagaagga tcattccgtg    900

tcacaacagc cactgaacaa gcagaaagag aggagatcat gaaacaaatg caagatgcca    960

agaaaggtac aatctgttct acagtgtgta tttatggaat gcagtttttc ccaacaaggt   1020

attattttga agctaccagg ggtaaatttt ctcataatca aagagaaccc ttagcaatat   1080

aaaaccttat aacaaagttg aaaatcttaa aaaccgcttc ctttagagtg gctagtttaa   1140

tggcttcaaa aatatttact ccattatagt aagctatctg aggaatcaga gtgcagttga   1200

agaagctgca gagacatctc ttaccccctt cctcccatcc tgaaatacct ttttaattct   1260

gatgtatctg atctctttga gaagcaaatg aatcaagtac ctgcatctta aaggaagcag   1320

cagaggtccc agggcttaag gctgcaaagc atccacggac tatgatgcta gcagagagat   1380

ttaacagtaa tactgtttat atgatattat tgctgttttt tagtgctttc tagtcacaaa   1440

agtctataga ttttgagagg taagcctata actctttttt tctatagccc tgttaattta   1500

atttagtgtg tgattttata gagtgtgagt tttatttagg tacacatggc atcacagcag   1560

aaatgcctgt acaaacattc aagttagttg gcagtctata aatgtgagtt gggtatattt   1620

tacaactaaa tgatagggct tgaaaatact tttgaattct tgtatataag tagggttaaa   1680

accaacaaga caagcacaaa caattcaagt taactaatag acattaatat aattttgagg   1740

ccaggtatag tggcttacag ctgtaatctc aatactttag gaggctgagg aggaaacatc   1800

acttgaggcc aggagtttgt gaccagactg tgcaacatag actctatccc ttaaaaaaaa   1860

aaaaaaaaaa aaaaaaaaaa aaaaattgcc atatttggtg gtgcacatcc gtaatcctag   1920

ctgcttggga ggctgagacc agaggattgc tggagcccag gagtacaagg ttacagtgag   1980

ctgtgatcat accactgcac tcctccagcc tgggtaacag caaaaccctg tctcttaaaa   2040

acaaacaaat atatatatat gataattttt tttactataa ccttttagtt ctaaactagt   2100

catttttgtt gttgttgttt tggtttgatt tcggtgtttt tttttttttt gagaca       2156


<210>  3112
<211>  245
<212>  PRT
<213>  Homo sapiens

<400>  3112


Met Asn Lys Leu Arg Gln Ser Phe Arg Arg Lys Lys Asp Val Tyr Val 
1               5                   10                  15      


Pro Glu Ala Ser Arg Pro His Gln Trp Gln Thr Asp Glu Glu Gly Val 
            20                  25                  30          


Arg Thr Gly Lys Cys Ser Phe Pro Val Lys Tyr Leu Gly His Val Glu 
        35                  40                  45              


Val Asp Glu Ser Arg Gly Met His Ile Cys Glu Asp Ala Val Lys Arg 
    50                  55                  60                  


Leu Lys Ala Thr Gly Lys Lys Ala Val Lys Ala Val Leu Trp Val Ser 
65                  70                  75                  80  


Ala Asp Gly Leu Arg Val Val Asp Glu Lys Thr Lys Asp Leu Ile Val 
                85                  90                  95      


Asp Gln Thr Ile Glu Lys Val Ser Phe Cys Ala Pro Asp Arg Asn Phe 
            100                 105                 110         


Asp Arg Ala Phe Ser Tyr Ile Cys Arg Asp Gly Thr Thr Arg Arg Trp 
        115                 120                 125             


Ile Cys His Cys Phe Met Ala Val Lys Asp Thr Gly Glu Arg Leu Ser 
    130                 135                 140                 


His Ala Val Gly Cys Ala Phe Ala Ala Cys Leu Glu Arg Lys Gln Lys 
145                 150                 155                 160 


Arg Glu Lys Glu Cys Gly Val Thr Ala Thr Phe Asp Ala Ser Arg Thr 
                165                 170                 175     


Thr Phe Thr Arg Glu Gly Ser Phe Arg Val Thr Thr Ala Thr Glu Gln 
            180                 185                 190         


Ala Glu Arg Glu Glu Ile Met Lys Gln Met Gln Asp Ala Lys Lys Gly 
        195                 200                 205             


Thr Ile Cys Ser Thr Val Cys Ile Tyr Gly Met Gln Phe Phe Pro Thr 
    210                 215                 220                 


Arg Tyr Tyr Phe Glu Ala Thr Arg Gly Lys Phe Ser His Asn Gln Arg 
225                 230                 235                 240 


Glu Pro Leu Ala Ile 
                245 

<210>  3113
<211>  966
<212>  DNA
<213>  Homo sapiens

<400>  3113
agttctcccg aggaaggtag gctacggccg gacccgcgcg ggtcaggcca ggaggtccct     60

tgggacgtcc agctgctccg gtctagcgcg ctgaccggcg gccactgtgt gaggaatttg    120

aggcttaagc aacttcttcc ggggaagagt gccagtgcag ccactgttac aattcaagat    180

cttgatctat atccatagat tggaatattg gtgggccagc aatcctcaga cgcctcactt    240

aggacaagct gtaaaaatta aaatgaacaa attacggcaa agttttagga gaaagaagga    300

tgtttatgtt ccagaggcca gtcgtccaca tcagtggcag acagatgaag aaggcgttcg    360

caccggaaaa tgtagcttcc cggttaagta ccttggccat gtagaagttg atgaatcaag    420

aggaatgcac atctgtgaag atgctgtaaa aagattgaaa gctgaaagga agttcttcaa    480

aggcttcttt ggaaaaactg gaaagaaagc agttaaagca gttctgtggg tctcagcaga    540

tggactcaga gttgtggatg aaaaaactaa ggacctcata gttgaccaga cgatagagaa    600

agtttctttc tgtgccccag acaggaactt tgatagagcc ttttcttaca tatgccgtga    660

tggcaccact cgtcgctgga tctgtcactg cttcatggct gtcaaggaca caggtgaaag    720

gttgagccat gcagtaggct gtgcttttgc agcctgttta gagcgcaagc agaagcggga    780

gaaggaatgt ggagtgactg ctacttttga tgctagtcgg accactttta caagagaagg    840

atcattccgt gtcacaacag ccactgaaca agcagaaaga gaggagatca tgaaacaaat    900

gcaagatgcc aagaaaggta caatctgttc tacagtgtgt atttatggaa tgcagttttt    960

cccaac                                                               966


<210>  3114
<211>  233
<212>  PRT
<213>  Homo sapiens

<400>  3114


Met Asn Lys Leu Arg Gln Ser Phe Arg Arg Lys Lys Asp Val Tyr Val 
1               5                   10                  15      


Pro Glu Ala Ser Arg Pro His Gln Trp Gln Thr Asp Glu Glu Gly Val 
            20                  25                  30          


Arg Thr Gly Lys Cys Ser Phe Pro Val Lys Tyr Leu Gly His Val Glu 
        35                  40                  45              


Val Asp Glu Ser Arg Gly Met His Ile Cys Glu Asp Ala Val Lys Arg 
    50                  55                  60                  


Leu Lys Ala Glu Arg Lys Phe Phe Lys Gly Phe Phe Gly Lys Thr Gly 
65                  70                  75                  80  


Lys Lys Ala Val Lys Ala Val Leu Trp Val Ser Ala Asp Gly Leu Arg 
                85                  90                  95      


Val Val Asp Glu Lys Thr Lys Asp Leu Ile Val Asp Gln Thr Ile Glu 
            100                 105                 110         


Lys Val Ser Phe Cys Ala Pro Asp Arg Asn Phe Asp Arg Ala Phe Ser 
        115                 120                 125             


Tyr Ile Cys Arg Asp Gly Thr Thr Arg Arg Trp Ile Cys His Cys Phe 
    130                 135                 140                 


Met Ala Val Lys Asp Thr Gly Glu Arg Leu Ser His Ala Val Gly Cys 
145                 150                 155                 160 


Ala Phe Ala Ala Cys Leu Glu Arg Lys Gln Lys Arg Glu Lys Glu Cys 
                165                 170                 175     


Gly Val Thr Ala Thr Phe Asp Ala Ser Arg Thr Thr Phe Thr Arg Glu 
            180                 185                 190         


Gly Ser Phe Arg Val Thr Thr Ala Thr Glu Gln Ala Glu Arg Glu Glu 
        195                 200                 205             


Ile Met Lys Gln Met Gln Asp Ala Lys Lys Gly Thr Ile Cys Ser Thr 
    210                 215                 220                 


Val Cys Ile Tyr Gly Met Gln Phe Phe 
225                 230             

<210>  3115
<211>  597
<212>  DNA
<213>  Homo sapiens

<400>  3115
agaagtatga aagagggtgg gcctgttgtc atgggggagg tggtggcgct tggtggccac     60

tggcggccga ggtagaggca gtggcgcttg agttggtcgg gggcagcggc agatttgagg    120

cttaagcaac ttcttccggg gaagagtgcc agtgcagcca ctgttacaat tcaagatctt    180

gatctatatc catagattgg aatattggtg ggccagcaat cctcagacgc ctcacttagg    240

acaaatgagg aaactgaggc ttggtgaagt tacgaaactt gtccaaaatc acacaacttg    300

taaagggcac agccaagatt cagagccagg ctgtaaaaat taaaatgaac aaattacggc    360

aaagttttag gagaaagaag gatgtttatg ttccagaggc cagtcgtcca catcagtggc    420

agacagatga agaaggcgtt cgcaccggaa aatgtagctt cccggttaag taccttggcc    480

atgtagaagt tgatgaatca agaggaatgc acatctgtga agatgctgta aaaagattga    540

aagctactgg aaagaaagca gttaaagcag ttctgtgggt ctcagcagat ggactca       597


<210>  3116
<211>  83
<212>  PRT
<213>  Homo sapiens

<400>  3116


Met Asn Lys Leu Arg Gln Ser Phe Arg Arg Lys Lys Asp Val Tyr Val 
1               5                   10                  15      


Pro Glu Ala Ser Arg Pro His Gln Trp Gln Thr Asp Glu Glu Gly Val 
            20                  25                  30          


Arg Thr Gly Lys Cys Ser Phe Pro Val Lys Tyr Leu Gly His Val Glu 
        35                  40                  45              


Val Asp Glu Ser Arg Gly Met His Ile Cys Glu Asp Ala Val Lys Arg 
    50                  55                  60                  


Leu Lys Ala Thr Gly Lys Lys Ala Val Lys Ala Val Leu Trp Val Ser 
65                  70                  75                  80  


Ala Asp Gly 
            

<210>  3117
<211>  1990
<212>  DNA
<213>  Homo sapiens

<400>  3117
agaagtatga aagagggtgg gcctgttgtc atgggggagg tggtggcgct tggtggccac     60

tggcggccga ggtagaggca gtggcgcttg agttggtcgg gggcagcggc agatttgagg    120

cttaagcaac ttcttccggg gaagagtgcc agtgcagcca ctgttacaat tcaagatctt    180

gatctatatc catagattgg aatattggtg ggccagcaat cctcagacgc ctcacttagg    240

acaaatgagg aaactgaggc ttggtgaagt tacgaaactt gtccaaaatc acacaacttg    300

taaagggcac agccaagatt cagagccagg ctgtaaaaat taaaatgaac aaattacggc    360

aaagttttag gagaaagaag gatgtttatg ttccagaggc cagtcgtcca catcagtggc    420

agacagatga agaaggcgtt cgcaccggaa aatgtagctt cccggttaag taccttggcc    480

atgtagaagt tgatgaatca agaggaatgc acatctgtga agatgctgta aaaagattga    540

aagctgtatg tatttgatgg ttgccagtgt tgatctatat gctatcaata ttttcttaaa    600

agattttgct cagtacattt tagtgaccca gtaaaaactg tgtttctgtt aaaaagatgt    660

gggcttgcta ataaggagca tctcagccaa gcgcggtggc tcactcctgt aatcctagca    720

ctttgggagg ctgaggcagg aggattacat gaggccagga gtttgagacc agcctgggca    780

acatttcaag accctgtctc tattaatttc aaaaattttt tcttaaataa taaaataata    840

attaaaaaat ttaaaagcat ctcatgttgc ccatccagag gtataaatta ttagatgagc    900

cgtttaaatt taggccagat attatcctaa aggtactttt gatttataac ccatatgaaa    960

caaatgttgt gaaatctgat agaagaatag tattctaaga ctaggattaa actgttacag   1020

ttaacatctt accctaactg tgataactgg gctataaatt aggggtttta aatatactgt   1080

aaaaaatagc ttcctgggga aaactagagg atagaggtct gtgttgatgc ctggtgaggt   1140

ttcctttttg gagacttctt actattacct tgactcctac tccccaattt tcttctctat   1200

acacctctaa cataaacagt ctatttctac tgccttttac ataaacttta gcacacttga   1260

agtagagagc cctttcccag gataacgttt cctctgcctg ttatgcgata gaacacatcc   1320

caggcacatg cctgtgtatt cagtgaaagg aaagaacgag ttcggaattc ataaagattc   1380

aaagtgttaa tttcagattt tccataggtt tgaggaatgt tccatagatc tgatagccct   1440

tttcacaacc ctccttctct ctaatatgtg gcctttcccc actttgctgt gaaagcttta   1500

agcattactt ctgcatgctc tggtcccaac agcattaaat acatgttgct ttgggtttgc   1560

tggtatggtg ggctgccaca agtttgacta ctaatgtgtg cttttttccc tcaatttgct   1620

tagtaatcag aacttttgtg cttctcggca tagtctatat tacttcttat ctataattcc   1680

tgaatataaa atatataaaa tttagagaaa aagcaaccaa gtcagagagg tagatttaat   1740

tttgggataa atacctgaat ctgtcataga agggaaaaga gaaaagtaat tggctataat   1800

atacaaagaa ctaaaaaatt ttaaaaaaag atacagacat acctacacat atatacatac   1860

atagatacct atacatactc tttatctcag attttgatca ttaaaattct taaatgattc   1920

aagcctttgc tagtcttatc tgtgctctcc caatctgtca ttacgttaag gggaccttgt   1980

gttatggtac                                                          1990


<210>  3118
<211>  70
<212>  PRT
<213>  Homo sapiens

<400>  3118


Met Asn Lys Leu Arg Gln Ser Phe Arg Arg Lys Lys Asp Val Tyr Val 
1               5                   10                  15      


Pro Glu Ala Ser Arg Pro His Gln Trp Gln Thr Asp Glu Glu Gly Val 
            20                  25                  30          


Arg Thr Gly Lys Cys Ser Phe Pro Val Lys Tyr Leu Gly His Val Glu 
        35                  40                  45              


Val Asp Glu Ser Arg Gly Met His Ile Cys Glu Asp Ala Val Lys Arg 
    50                  55                  60                  


Leu Lys Ala Val Cys Ile 
65                  70  

<210>  3119
<211>  752
<212>  DNA
<213>  Homo sapiens

<400>  3119
ggggaggtgg tggcgcttgg tggccactgg cggccgaggt agaggcagtg gcgcttgagt     60

tggtcggggg cagcggcaga tttgaggctt aagcaacttc ttccggggaa gagtgccagt    120

gcagccactg ttacaattca agatcttgat ctatatccat agattggaat attggtgggc    180

cagcaatcct cagacgcctc acttaggaca aattgtattt atgagcttgt gttgcagtta    240

tctattgctg tgtaacaaag tacctcaaac ttagtggctt aaaacaacag tcatttattt    300

tgttcatata tttgcagttt gagcaaggct tgattggtag ggatgcttgt ctctgttaac    360

atacagcatg aggtggggtg gctggaaggg ttggagtggc tcagtggctg ggaactggga    420

tcctttgaag gtaggcttgc tcactcacat atctggtggt taaagctggc tgttggctag    480

gacctcagcc tgggctgttg gcaagaacac cttcatgtga cttctccttg tggctgcttg    540

gcttcttcac agcatggtgc ctgggttccg agagagagag catcccaaga gaggaaggca    600

aaggtgcatg gcatatttga cttggttttg gaagtcacat agtgttactt tgctctgtcc    660

tactggttga tgtagttgta aaggttctcc caagtttcaa ggaagctgtg gacatagacc    720

ccaccacttg aaaggatcaa catcatattg ta                                  752


<210>  3120
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  3120


Met Leu Val Ser Val Asn Ile Gln His Glu Val Gly Trp Leu Glu Gly 
1               5                   10                  15      


Leu Glu Trp Leu Ser Gly Trp Glu Leu Gly Ser Phe Glu Gly Arg Leu 
            20                  25                  30          


Ala His Ser His Ile Trp Trp Leu Lys Leu Ala Val Gly 
        35                  40                  45  

<210>  3121
<211>  699
<212>  DNA
<213>  Homo sapiens

<400>  3121
ttaggaaact attctatatt tgggccactt gtgagaactg atagcctagt aaagtatcgg     60

ataataatga taatattagt actagcagca gccaatgcta cattccaaga agcgttctaa    120

gtgctttaca tgcactaact aatttaatcc tcatgataac tcctgtgagg gcagctacta    180

ttataatctt tatgttactg gtagggaatc tgagatagag aaggtaagtg atttgcccaa    240

tatcatagag taagtggtag aactgggatt caaacctaga tagtttggct ccagagctca    300

tactcttaac tttcagtgct aaatggatta aattaaatgt agtcagtttt actttgttgt    360

tgagcatatc attgtgcagt agtagtggcc caagtttaaa ttgggatttc tttttttttg    420

agacagagtc tccctatgtc acccaggctg gagtgcagtg gcacgatctt ggctcatgca    480

acctctgcct cccaggttca agcaattctc ctgtctcagc ctcccgagta gtgggattac    540

aggcgtgaac caccatgtca tgcccgccta atttttgtat ttttttagta gagacagggt    600

ttcaccatgt tggccaggct gatctcgaac tcctgacctc aagtgatcca cctgcctcgg    660

cctcccaaag tgctgggatt acaggtgtga gctactgcc                           699


<210>  3122
<211>  47
<212>  PRT
<213>  Homo sapiens

<400>  3122


Met Ser Cys Pro Pro Asn Phe Cys Ile Phe Leu Val Glu Thr Gly Phe 
1               5                   10                  15      


His His Val Gly Gln Ala Asp Leu Glu Leu Leu Thr Ser Ser Asp Pro 
            20                  25                  30          


Pro Ala Ser Ala Ser Gln Ser Ala Gly Ile Thr Gly Val Ser Tyr 
        35                  40                  45          

<210>  3123
<211>  600
<212>  DNA
<213>  Homo sapiens

<400>  3123
gagagagaaa aaatatatag gtacaaatat atttaagagt ttcttttttt ttctttattt     60

ttttgagatg gagtcttgct ctgtcaccag gctggagtgc agtgatacga tctcagttta    120

ctgcaacctc cgcctcctgg gttcaagcga ttctcctgcc tgtaatccca gctaaaactc    180

aggaggctga ggcaggagaa tcccttgaac ccagggggca gaggttgcag tgagccgaga    240

tcacgctact gtggtccatc ctgggcgaca gagtgggact ccgtcaacaa aaacaaaaca    300

aaacaaaaat ccttcaaaag tttctattgt gataagaaaa cccaagtgag ttactaaaca    360

aaaagtaagg ttattttcag aatcaaaatg atcttcaact agagactgtt taaaatgtac    420

tttaaaatga gacagaattt gaagaaacta aaaataaggc taaaaatagg catcctcatt    480

gtatagtaaa ttctacatca ttattgtaga caacagataa tttctaagtg acacaatatg    540

tcattttatg aatatactac actttgtttt tccattcttc tattgatatt tgtgtcattt    600


<210>  3124
<211>  35
<212>  PRT
<213>  Homo sapiens

<400>  3124


Met Glu Ser Cys Ser Val Thr Arg Leu Glu Cys Ser Asp Thr Ile Ser 
1               5                   10                  15      


Val Tyr Cys Asn Leu Arg Leu Leu Gly Ser Ser Asp Ser Pro Ala Cys 
            20                  25                  30          


Asn Pro Ser 
        35  

<210>  3125
<211>  438
<212>  DNA
<213>  Homo sapiens

<400>  3125
tttgagacaa agtcgcactc tgtcgcccag gctggagtgc agtggcacta tcttggtcac     60

tgcaacctcc gcctcctggg ttcaagcaat tctcctgcct caacctcctg agtacctggg    120

actacaggcg cacgccacca cgcctggcta atttttgtat tttcagtaga gatgggtttc    180

accatgttgg ccaggaaagt ctcgatctct tgaccttgtg atctagagaa aaattgtaga    240

ctaaagcaat atgttctaaa catatgtatg tatgtatata tagtttcatt cttcaaataa    300

atattgagat gagttttaaa catctttatt ttaaaggctt gcctcaattc agggtagctt    360

tggttgtgtt ttgattattt tctccatcaa tggatgctga aaattcagct attaccatgt    420

gaggatcagt taaatatt                                                  438


<210>  3126
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  3126


Met Tyr Val Cys Ile Tyr Ser Phe Ile Leu Gln Ile Asn Ile Glu Met 
1               5                   10                  15      


Ser Phe Lys His Leu Tyr Phe Lys Gly Leu Pro Gln Phe Arg Val Ala 
            20                  25                  30          


Leu Val Val Phe 
        35      

<210>  3127
<211>  430
<212>  DNA
<213>  Homo sapiens

<400>  3127
aactccatct taaaaaaaaa aaaaaaggtt tttttgggag tattatattc cattaaattt     60

cttcagtttc tgatttggtt cctcctgtgt ttgtcttgtc acatattgtg ttatgcctct    120

gactctggaa cttttttgga tattgagaat ctttggcatg agaacttaag ggaatctgag    180

gcagagaaat tgaatggtgt ttctcagatg ttgtccgctt ttgtttcact tgtgccctct    240

tgttcaccct ttctttttta tcactgtacc gtaaagcatt gtttgtaaaa gcctgagtat    300

acacagacat attgacagta aacaacactg aaatggactg acttgagaaa atttcatgta    360

tagaaaataa gcaaaaacaa agtaagaaac atgcactcca tcctgggcga caaagcgaga    420

ctttgttttg                                                           430


<210>  3128
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  3128


Gly Arg Glu Ile Glu Trp Cys Phe Ser Asp Val Val Arg Phe Cys Phe 
1               5                   10                  15      


Thr Cys Ala Leu Leu Phe Thr Leu Ser Phe Leu Ser Leu Tyr Arg Lys 
            20                  25                  30          


Ala Leu Phe Val Lys Ala 
        35              

<210>  3129
<211>  723
<212>  DNA
<213>  Homo sapiens

<400>  3129
ctctctcttg ctcttgcttg cttgcactga tgaagtaagc tgccacgttg tgagatgctc     60

aacgaagagg cccatgaggc agggcaccga gggaggcttc tggccaacag ctcctgggga    120

accaaggcct taggaagtga gtcctgccaa caataacgag agccttgaac tttgaaacca    180

cagtaccttg ttccagcgtg gaaagcagcg tggcacttcc cggtggtgaa agcaccccag    240

cttgaaaggg tgaaaacacc ttctcccaga tagtctccct ttgtttagcc agtgcttttg    300

ccttaaggaa atcaaatgaa ggggtcagcc aggagtggat ctggaagctg gagaactctc    360

aatacgccac ttcagtttat tgacgacatt tataattgca accgaagttg actgatttct    420

gctaaatgaa agtttgcgct ttgcccttta gcattgaggc tcctggaaag aacttcaatg    480

aaattggatg cattgagacc aaagaaaaga aggggacatt tttatctctc tgataccttt    540

ctccccaggg cttggaaaca cttcttaaac acaacctcta atgttggtgt tttgtaagta    600

ctacccctat gaataaagct agcagagata agcttctcct tgcaggaagt gagctggaga    660

agtggaaaag tttacagaga aaactctaca acaaagactt aacccttccc gggtaaccac    720

gaa                                                                  723


<210>  3130
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  3130


Met Lys Gly Ser Ala Arg Ser Gly Ser Gly Ser Trp Arg Thr Leu Asn 
1               5                   10                  15      


Thr Pro Leu Gln Phe Ile Asp Asp Ile Tyr Asn Cys Asn Arg Ser 
            20                  25                  30      

<210>  3131
<211>  634
<212>  DNA
<213>  Homo sapiens

<400>  3131
cttgcttgca ctgatgaagt aagctgccac gttgtgagat gctcaacgaa gaggcccatg     60

aggcagggca ccgagggagg cttctggcca acagctcctg gggaaccaag gccttaggaa    120

gtgagtcctg ccaacaataa cgagagcctt gaactttgaa accacagtac cttgttccag    180

cgtggaaagc agcgtggcac ttcccggtgg tgaaagcacc ccagcttgaa agggtgaaaa    240

caccttctcc cagatagtct ccctttgttt agccagtgct tttgccttaa ggaaatcaaa    300

tgaagtgtat gaaatagcgg ctgacttttg tgacaatttt ccacccagtt ttgtgatagt    360

aatttcgctg cattcttcaa cttagatggc aagtcctctt agcaaggctg gcctaattct    420

atgttttcta tggcacctag tcactatggc tgtgcaagag ccattattac ccaaagtacc    480

ataataatgg tcatgtcctc ctatgacgtt attgtttcct atctgtcagg acattaattg    540

tcttctaact tgctctaaaa ttggtagcat ggcacactgc caagactaga gagaagcaag    600

ctgctggtga tatattaaaa ggctgtgtaa aagg                                634


<210>  3132
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  3132


Met Phe Ser Met Ala Pro Ser His Tyr Gly Cys Ala Arg Ala Ile Ile 
1               5                   10                  15      


Thr Gln Ser Thr Ile Ile Met Val Met Ser Ser Tyr Asp Val Ile Val 
            20                  25                  30          


Ser Tyr Leu Ser Gly His 
        35              

<210>  3133
<211>  757
<212>  DNA
<213>  Homo sapiens

<400>  3133
gagatctcgc cactgcactc cagcctgagc gacagagtaa ggctccacca tttctaactc     60

acaggatgtg gcaacagtga tgggatgtca catctgtgat tggattacga aagactgtgc    120

cttctgtttt gctattactg tctctggtga gtcctctctc ttgctcttgc ttgcttgcac    180

tgatgaagta agctgccacg ttgtgagatg ctcaacgaag aggcccatga ggcagggcac    240

cgagggaggc ttctggccaa cagctcctgg ggaaccaagg ccttaggaag tgagtcctgc    300

caacaataac gagagccttg aactttgaaa ccacagtacc ttgttccagc gtggaaagca    360

gcgtggcact tcccggtggt gaaagcaccc cagcttgaaa gggtgaaaac accttctccc    420

agatagtctc cctttgttta gccagtgctt ttgccttaag gaaatcaaat gaaggtatgc    480

tccttggttg gctgctgaat ctgtccttcc ttgtcagctt tgcccagagc agcaggcttt    540

gagctctggg aggatttcca ggtggcagca gaacaacggt cccataggct ggagcctggc    600

acgctttccc ttttaaccag tggcagaggc tgcactttgc tggtgtaatt atgcaaccta    660

gtgtaaagtc cacatgggtg gggatagggg gtaggcaagg caggactgta agctggctca    720

gcactctgat tgggtttttt gactgttttt ctagctt                             757


<210>  3134
<211>  68
<212>  PRT
<213>  Homo sapiens

<400>  3134


Met Gly Cys His Ile Cys Asp Trp Ile Thr Lys Asp Cys Ala Phe Cys 
1               5                   10                  15      


Phe Ala Ile Thr Val Ser Gly Glu Ser Ser Leu Leu Leu Leu Leu Ala 
            20                  25                  30          


Cys Thr Asp Glu Val Ser Cys His Val Val Arg Cys Ser Thr Lys Arg 
        35                  40                  45              


Pro Met Arg Gln Gly Thr Glu Gly Gly Phe Trp Pro Thr Ala Pro Gly 
    50                  55                  60                  


Glu Pro Arg Pro 
65              

<210>  3135
<211>  1547
<212>  DNA
<213>  Homo sapiens

<400>  3135
accgttgttc tgctgccacc tggaaatcct cccagagctc aaagcctgct gctctgggca     60

aagctgacaa ggaaggacag attcagcagc caaccaagga gcataccttc atttgatttc    120

cttaaggcaa aagcactggc taaacaaagg gagactatct gggagaaggt gttttcaccc    180

tttcaagctg gggtgctttc accaccggga agtgccacgc tgctttccac gctggaacaa    240

ggttgctttt tatatttttg acaataacag agccacggga agaaaggatg tgattagggg    300

aagaaaaaag gggagaggtt catgttgtct ttattttcat taatgaatgt ctcaaacatt    360

ttagggtata aatagcaatc agtatttagg aaaggaagct ggattcacac tacttggaaa    420

tctgggtctt tactcatcca tggcaatttt tgggtatcat gtgctcttac agaatctcat    480

cttatgatat agattcagtt tacagctatt ctatgatgct tgagtatttc aaatattaag    540

tacattgagg ctcatgagaa ttgctaatct gccgtgtgaa actgcagagt tgtttcccaa    600

gggtagagat gcattcacat ccacccacat agtacaaagg gggaaatgat tacgctggcc    660

tggatttttt gtaatagtcc cgtgacatgg cttccacatt gctctgtggg ctgtggttaa    720

agaacctaat ctagaacaag acaagacttg tagatttaaa aagtcaccta agctgtttct    780

ttcctagaca aatgggattc tagtttgggc taatttgagt ttcagagggc aatttgtacc    840

gtttggaaaa gatgctggat ccttcaatat tactgcttta gaaagatttg gaactctgac    900

ccatatttag tacatgacct ttctggggcg tggaaaaata tgctctgtca tctaatgtga    960

tgtcaatttt ctttaacctt ccatgtaaat agtgcgcatt aagacatgag gtctactgtt   1020

aaataatttc tctttataaa catagtgaca acaagattgt acagtatcaa ttaaaaagac   1080

ccaatgtgac caggtccact gcttcctgca tcttgaagta agacaagtgt tcagcttaga   1140

gatgagcacc tttctttcca gagggagaag acatgatggg agaaaaaaat gttctctctg   1200

agaatttacc cagataaaga gctgggtagt cggatctaaa tggtcccaca gcaatccttt   1260

tctcggggga ggtgcgtaga tctttgacaa gtgatgaacg aactttgctt cgtgtggtta   1320

ggcctgggac tgaactttgt aaccagggat ttggtgcgcg gggcttcaca ggctgcagag   1380

aaacatgaaa acatgagtgc atatgccaaa cgtgtctcat gtgagcggca gagcccaagt   1440

gaaggcctct ttggctatag ggtgtctcca gattattctt taattaatct caaaagccta   1500

acaccagggt agtctctctc agcctactct ggcttgaaaa gctgccc                 1547


<210>  3136
<211>  72
<212>  PRT
<213>  Homo sapiens

<400>  3136


Met Asn Glu Leu Cys Phe Val Trp Leu Gly Leu Gly Leu Asn Phe Val 
1               5                   10                  15      


Thr Arg Asp Leu Val Arg Gly Ala Ser Gln Ala Ala Glu Lys His Glu 
            20                  25                  30          


Asn Met Ser Ala Tyr Ala Lys Arg Val Ser Cys Glu Arg Gln Ser Pro 
        35                  40                  45              


Ser Glu Gly Leu Phe Gly Tyr Arg Val Ser Pro Asp Tyr Ser Leu Ile 
    50                  55                  60                  


Asn Leu Lys Ser Leu Thr Pro Gly 
65                  70          

<210>  3137
<211>  930
<212>  DNA
<213>  Homo sapiens

<400>  3137
caggtcctga attatgtata ttatttcatt tactcctcat aaaagggttc cttctaggag     60

ctaggggaga aaaccagcca ttatatagtc aataataata ttaatggtaa taatagttat    120

tatatataac agttatatat tacataacat atgctggccc gaattgaaca tattctctaa    180

tttgattttt gaatatttaa aaatatacac atatatttgt tttttttttt taagagatgg    240

aggagtctca ccatgttgcc caagctggcc tcaaacccct ggcctcaagt gagcctccca    300

cctcagcctc ccaagtagct gccaccatgc agtctctaat ttaaatttta aacaaaccct    360

agatgttatt attatcttag agtaggctgc ttctaaaata gctcccaatg atcctcttgc    420

tggtctttac atccttgtgt aatctccttg agtgtgggct ggacctaatg acttacttct    480

aactcacagg atgtggcaac agtgatggga tgtcacatct gtgattggat tacgaaagac    540

tgtgccttct gttttgctat tactgtctct ggtgagtcct ctctcttgct cttgcttgct    600

tgcactgatg aagtaagctg ccacgttgtg agatgctcaa cgaagaggcc catgaggcag    660

ggcaccgagg gaggcttctg gccaacagct cctggggaac caaggcctta ggaagtgagt    720

cctgccaaca ataacgagag ccttgaactt tgaaaccaca gtaccttgtt ccagcgtgga    780

aagcagcgtg gcacttcccg gtggtgaaag caccccagct tgaaagggtg aaaacacctt    840

ctcccagata gtctcccttt gtttagccag tgcttttgcc ttaaggaaat caaatgaagg    900

tatgctcctt ggttggctgc tgaatctgtc                                     930


<210>  3138
<211>  68
<212>  PRT
<213>  Homo sapiens

<400>  3138


Met Gly Cys His Ile Cys Asp Trp Ile Thr Lys Asp Cys Ala Phe Cys 
1               5                   10                  15      


Phe Ala Ile Thr Val Ser Gly Glu Ser Ser Leu Leu Leu Leu Leu Ala 
            20                  25                  30          


Cys Thr Asp Glu Val Ser Cys His Val Val Arg Cys Ser Thr Lys Arg 
        35                  40                  45              


Pro Met Arg Gln Gly Thr Glu Gly Gly Phe Trp Pro Thr Ala Pro Gly 
    50                  55                  60                  


Glu Pro Arg Pro 
65              

<210>  3139
<211>  1143
<212>  DNA
<213>  Homo sapiens

<400>  3139
gacgattgcc attcgcccag cagcccacgc tgagtttgta cccaaagccg acttgctcac     60

cctcccggga gctgaggctg gggctcatgg ctccaggcgg cagggcaagg agcggcaagg    120

ggataggtca tcgcagtcgc cagccgggga aacagcctcc atttctagtg tgtcggccag    180

tgccgagggg gccgtgaaca aggtccccct gaaggtgata gagagtgaga agttagatga    240

agcccctgag gggaaaagac tgggcttccc tgtccacacg agtgtccctc acactcgccc    300

agaaacgaga aacaagagga gagccgggtt gccccttggt ggccacaagt ccttgtttct    360

ggatctgccc cacaaagtag gtcctgactc ctcacaaccc agaggtgata agaagaagcc    420

atccccacca gcaccggcag ctcttggcaa ggtgtttaat aattcagcct cgcagtccag    480

cacacacaaa cagacgtcac ctgttccctc gcctctgtct ccaaggctcc ccagccctca    540

gcagcatcac aggatcctcc ggctccctgc attgcctggt gagagggaag ctgctcttaa    600

tgactctcct tgtagaaaga gccgtgtctt ctctgggtgc gtctctgctg acaccttgga    660

gccaccatcc tctgcaaagg tcacggagac caaaggagcc agcccggcct tcctcagagc    720

aggccaacct cggttggtgc ctggggaaac tttggaaaag agcttggggc cagggaagac    780

cacagctgag ccccagcacc agtcacctcc aggtatctcc tctgagggct ttccctggga    840

cggcttcaat gagcagacac ctaaagacct tcccaacaga gatggaggcg cgtgggttct    900

gggctacaga gcgggaccag cctgtccatt tttgcttcat gaggaaaggg agaagtcaaa    960

caggagcgaa ttgtacttgg atctccatcc tgaccacagc ctgactgagc aggatgacag   1020

gactcctggc agacttcaag ctgtctggcc acccccaaag acaaaagaca cagaagaaaa   1080

agtgggactg aagtacactg aagcagaata ccaagctgct attttacact tgaagaggga   1140

gca                                                                 1143


<210>  3140
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  3140


Met Thr Leu Leu Val Glu Arg Ala Val Ser Ser Leu Gly Ala Ser Leu 
1               5                   10                  15      


Leu Thr Pro Trp Ser His His Pro Leu Gln Arg Ser Arg Arg Pro Lys 
            20                  25                  30          


Glu Pro Ala Arg Pro Ser Ser Glu Gln Ala Asn Leu Gly Trp Cys Leu 
        35                  40                  45              


Gly Lys Leu Trp Lys Arg Ala Trp Gly Gln Gly Arg Pro Gln Leu Ser 
    50                  55                  60                  


Pro Ser Thr Ser His Leu Gln Val Ser Pro Leu Arg Ala Phe Pro Gly 
65                  70                  75                  80  


Thr Ala Ser Met Ser Arg His Leu Lys Thr Phe Pro Thr Glu Met Glu 
                85                  90                  95      


Ala Arg Gly Phe Trp Ala Thr Glu Arg Asp Gln Pro Val His Phe Cys 
            100                 105                 110         


Phe Met Arg Lys Gly Arg Ser Gln Thr Gly Ala Asn Cys Thr Trp Ile 
        115                 120                 125             


Ser Ile Leu Thr Thr Ala 
    130                 

<210>  3141
<211>  6288
<212>  DNA
<213>  Homo sapiens

<400>  3141
aacgcctgca tgaacttccg gctacacgcc attccgcttc ccgaggaacg cttgggctgt     60

tgtacgggtt ccctacggga ctctgaaggc tgaggatatc cggcccggag cgtttgtgcg    120

gcgcggagtt aagcgccccg gcagtaactt aagggaagtg gaccagggtt gccgctgccc    180

agagcggtcc tttagtttcc actggagtgg agggaagagt gctgccatgg cagcccctgc    240

gcagcccaag aagatcgtgg cccctacggt gtcccaaatc aatgcggagt tcgtgaccca    300

gttagcatgt aaatactggg ctccccacat caagaagaaa tcaccttttg atataaaggt    360

tattgaagat atatatgaaa aagagattgt caaatcaagg tttgctatta gaaagataat    420

gctcttggaa tttagccagt atcttgaaaa ttatctctgg atgaattatt ctcctgaggt    480

atctagcaag gcctatttaa tgtcaatctg ctgtatggtg aatgagaagt ttagagaaaa    540

cgtgcctgca tgggagattt ttaagaagaa gccagaccac ttcccattct tttttaaaca    600

catcttgaag gcggcattag ctgaaactga tggtgaattt tcacttcatg aacagacagt    660

cttactactt tttcttgatc attgcttcaa tagtttggaa gtagacttga tacgaagtca    720

agtacagcag cttatctccc tcccaatgtg gatgggctta cagctggcac gattggaatt    780

agaattaaaa aagacaccta agctaagaaa attctggaac ttgattaaaa agaatgatga    840

aaagatggat ccagaagcaa gagaacaggc atatcaagag aggagatttc tttcacaact    900

catccagaag tttatctctg tgctgaaatc agtcccactt tctgaacctg tcactatgga    960

caaagttcat tactgtgaaa gattcattga acttatgatt gatctagagg ccctgctacc   1020

cacaaggcgc tggtttaata ccatcctgga tgattcccac cttctggttc actgttacct   1080

ttccaatctt gttcgtagag aagaggatgg ccatcttttt tcccagcttt tggacatgct   1140

taaattctat actggttttg aaattaatga ccaaactgga aatgctctga cagagaatga   1200

gatgaccaca attcactatg atagaattac ttctctacag agagctgctt ttgcacattt   1260

tcctgaactc tatgattttg ccctctcaaa tgtggcagaa gtagatactc gggagtcctt   1320

ggtcaagttt tttggacctc ttagttcaaa cacactccac caggtggcat catacctctg   1380

cttgttgcca actcttccta aaaatgaaga cacaactttt gataaagaat ttcttctaga   1440

attgctggta tctcgtcatg aacgtcgaat ttctcagatt cagcagttga accagatgcc   1500

tttgtatcca actgagaaaa ttatatggga tgaaaatatt gtcccaactg agtactattc   1560

tggagaaggt tgtcttgctc ttcccaaatt gaatttgcag tttttgactc ttcatgacta   1620

cctgctaagg aactttaacc tcttccgctt agaatcaact tatgaaattc gtcaggacat   1680

tgaagatagt gtcagcagaa tgaagccatg gcaatctgaa tatggcggtg tagtgtttgg   1740

tggttgggcg cgaatggccc agcccattgt ggctttcact gtcgttgaag tggccaaacc   1800

caacataggt gaaaactggc caacccgagt tcgtgcagat gttaccataa atctcaatgt   1860

cagagatcac atcaaagatg aatgggaagg tcttcgtaag catgatgtat gctttttaat   1920

taccgtacgt cccacaaaac cttatggcac taagtttgac cggaggagac cttttattga   1980

gcaggttggc ctggtttatg tcagaggctg tgaaattcag ggcatgctgg atgataaagg   2040

acgtgtcatt gaagatggac ctgaacccag acccaatctt agaggagaat caaggacatt   2100

tagagtgttt ttggatccaa accagtatca acaagatatg accaatacta tacaaaatgg   2160

agcagaggat gtgtatgaaa cttttaatat aataatgagg agaaaaccaa aggaaaataa   2220

ctttaaggct gtgctggaga ctattcggaa cctgatgaat actgattgtg tggtacctga   2280

ctggctgcac gatatcattt taggttatgg ggacccaagt agtgcacatt attcgaaaat   2340

gcccaatcag attgccaccc ttgatttcaa tgatacattt ctctccattg agcatttaaa   2400

agccagcttc cctggtcata atgttaaagt aactgtagaa gaccctgctc tacaaatacc   2460

ccctttcagg ataacttttc cagtaagaag tggaaaaggg aagaaaagga aagatgcgga   2520

tgtggaagat gaagacaccg aggaagcaaa aaccttaatt gttgagcccc atgttattcc   2580

taataggggt ccttatcctt ataatcaacc caaacgtaat acgattcagt tcactcatac   2640

acagatagaa gccatccgtg ctggaatgca gcctgggctg actatggttg tgggcccacc   2700

tggtacaggc aaaacagatg tggcagttca gatcatatcc aacatctacc acaacttccc   2760

agaacagagg actctaattg ttactcattc caatcaggcc ctaaaccagt tgtttgagaa   2820

aatcatggca ttagacattg atgagcgcca cctactgcgt cttggtcatg gagaagaaga   2880

gctggagaca gagaaagatt tcagcaggta tggaagagtt aattatgttc tggctcgaag   2940

aatagaactt ttagaagaag tcaaacgatt gcaaaagagt ctaggggttc caggagatgc   3000

ctcatatacc tgtgaaactg caggctattt cttcttatac caggtaatgt ctcgctggga   3060

agagtatatc agcaaagtga aaaataaagg tagtacattg ccagatgtta cggaagtctc   3120

cactttcttc cctttccatg aatactttgc aaatgctcct caacccattt ttaaaggaag   3180

atcttatgaa gaagacatgg aaattgctga aggatgtttc aggcatatta agaaaatctt   3240

tacgcagctt gaggaattca gagcctctga attgcttcga agtggactgg acagatctaa   3300

atacctttta gtgaaagaag ccaaaattat tgctatgacc tgtactcatg ctgccttaaa   3360

acgacatgac ttggtcaagc taggtttcaa gtatgacaac attttgatgg aagaggctgc   3420

tcagattctg gagatagaaa cttttatccc tcttcttcta cagaatcctc aggatggatt   3480

tagccgacta aaacgatgga ttatgattgg cgatcatcac cagttacctc cagttattaa   3540

gaacatggcc tttcaaaagt actcaaacat ggagcagtct ctcttcactc gctttgttcg   3600

cgttggagtt ccgactgttg accttgatgc tcaagggaga gccagagcaa gcttgtgcaa   3660

cctctacaac tggcgataca agaatctagg aaacttaccc catgtgcagc tcttgccaga   3720

gtttagtaca gcaaatgctg gcttactgta tgacttccag ctcattaatg ttgaagattt   3780

tcaaggagtg ggagaatctg aacctaatcc ttacttctat cagaatcttg gagaggcaga   3840

atatgtagta gcacttttta tgtacatgtg tttacttggt taccctgctg acaaaatcag   3900

tattctaaca acatataatg gccaaaagca tcttattcgc gacatcatca atagacgatg   3960

tggaaacaat ccattgattg gaagaccaaa caaggtgaca actgttgata gatttcaagg   4020

tcaacagaat gactatattc ttctttctct ggtacgaacc agggcagtgg gccatctgag   4080

ggatgtccgt cgcttggtag tggccatgtc tagagccaga cttggacttt atatcttcgc   4140

cagagtatcc ctcttccaaa actgttttga actgactcca gctttcagtc agctcacagc   4200

tcgccccctt catttgcata taattccaac agaacctttc ccaactacta gaaagaatgg   4260

agagagacca tctcatgaag tacaaataat aaaaaatatg ccccagatgg caaactttgt   4320

atacaacatg tacatgcatt tgatacagac tacacatcat tatcatcaga ctttattaca   4380

actaccacct gctatggtag aagagggtga ggaagttcaa aatcaagaaa cagaattgga   4440

aacagaagaa gaggccatga ctgttcaagc tgacatcata cccagtccaa cagacaccag   4500

ctgccgtcaa gaaactccag cctttcaaac tgacaccacc cccagtgaga caggagccac   4560

ttccactcca gaagccatcc ctgctttatc tgagaccacc cctactgtgg taggagctgt   4620

atctgcaccg gcagaagcta acacacctca ggatgccaca tctgccccgg aagagaccaa   4680

gtagccaaac tgtagtcctt ctaaaggagg acatggcagt caaaaagtct gagtaaagct   4740

gttttttgta ttttatattt gcttctgcca ttttactgtc actaattaat gtttagttct   4800

tatatttgtt aactgatttc ggtgtcttga atatattttt ttaaattatg tgtatgaaca   4860

attctagttt catttgttca atcagaagag caaataacca ttcctttcat gttttgatca   4920

ctgagtgtgt ctgtaatcat acctacatta aaatcatttt ctatgaatat ataatatata   4980

cttcacattt ttagtgaact tctctaaaga agaggacaga atatactgga cttaaccacg   5040

aatacccttg agtgtccaaa ttgggaagga acttgtttct tctgttatac tatcaaatgc   5100

ttaaattctg tttccttttt tcttaccttt gtttgctgtc tttatgtaaa gatattatta   5160

gcagtaagat acaggtttct tcaatctatc aaagtggtta catgcatttc cttctctcaa   5220

atcttagaat gccttagaat cacctaagat gtctgtttat tcttgaggca cacctcagac   5280

tgaatgagtc agaatctcag gattagagcc taggaatcta tattttagga ggttctccac   5340

accactaatg tttgggttgc tggcagagtg gcatcagcca aggctggtta ggctgagcca   5400

ggatttgtca tcagctaaat aggaggactc tgccaaatca atctgggcaa gaagcaggat   5460

cctgagtctg ggcaatgaga gtcagagaac ttaactcctg tgtgcagggt agaattttcc   5520

catggcagaa attctgagtt ttctgcctta tttttcttgg gataaccagc cacaaggaga   5580

ccttcaggta aaatgtggtt caaatatggg aaggcagagg tacctgggac cttgctactc   5640

aagtatgatt tgtgaaccaa cagcatcaac atcgtattga agtttgttat ttatagaaat   5700

gcagaagttt gggctctgct ccaaacctat taaatctaaa tctacattgc aacaaagtcc   5760

ccaggtgatt cacaggcact ttgtagtttg agaagcactg tactaagatt actgtgttgt   5820

cttcacatga atgaggctat aatgtagaat taccagtgaa tgtgactaat gttttctgac   5880

aagggacctc tgcttacaag gtccctgggc atggtgccca gaactggaaa aaaaaaaaaa   5940

aaaaaggaaa tgtttatatg tatgtgtaga ggggaaaatt gcccactagt tctctatttc   6000

ccattttgat catctgctag agtatctaaa ggggagggga gcatttaccc cagaatgtct   6060

cctctagtgc atccacctat gggcctggcc atgtccaagg aatctttgaa gaaacaagca   6120

agaactgcac actaccattg aaatccttct ggtcctgaca ttttgaagga atgattgctt   6180

catagggaaa ttaaacccag aaagtcaagt cagttatatt tttgagtgac tagtgtttgc   6240

tcagctctac caggctgtgt tgaatatggt acagactctc attttatg                6288


<210>  3142
<211>  1485
<212>  PRT
<213>  Homo sapiens

<400>  3142


Met Ala Ala Pro Ala Gln Pro Lys Lys Ile Val Ala Pro Thr Val Ser 
1               5                   10                  15      


Gln Ile Asn Ala Glu Phe Val Thr Gln Leu Ala Cys Lys Tyr Trp Ala 
            20                  25                  30          


Pro His Ile Lys Lys Lys Ser Pro Phe Asp Ile Lys Val Ile Glu Asp 
        35                  40                  45              


Ile Tyr Glu Lys Glu Ile Val Lys Ser Arg Phe Ala Ile Arg Lys Ile 
    50                  55                  60                  


Met Leu Leu Glu Phe Ser Gln Tyr Leu Glu Asn Tyr Leu Trp Met Asn 
65                  70                  75                  80  


Tyr Ser Pro Glu Val Ser Ser Lys Ala Tyr Leu Met Ser Ile Cys Cys 
                85                  90                  95      


Met Val Asn Glu Lys Phe Arg Glu Asn Val Pro Ala Trp Glu Ile Phe 
            100                 105                 110         


Lys Lys Lys Pro Asp His Phe Pro Phe Phe Phe Lys His Ile Leu Lys 
        115                 120                 125             


Ala Ala Leu Ala Glu Thr Asp Gly Glu Phe Ser Leu His Glu Gln Thr 
    130                 135                 140                 


Val Leu Leu Leu Phe Leu Asp His Cys Phe Asn Ser Leu Glu Val Asp 
145                 150                 155                 160 


Leu Ile Arg Ser Gln Val Gln Gln Leu Ile Ser Leu Pro Met Trp Met 
                165                 170                 175     


Gly Leu Gln Leu Ala Arg Leu Glu Leu Glu Leu Lys Lys Thr Pro Lys 
            180                 185                 190         


Leu Arg Lys Phe Trp Asn Leu Ile Lys Lys Asn Asp Glu Lys Met Asp 
        195                 200                 205             


Pro Glu Ala Arg Glu Gln Ala Tyr Gln Glu Arg Arg Phe Leu Ser Gln 
    210                 215                 220                 


Leu Ile Gln Lys Phe Ile Ser Val Leu Lys Ser Val Pro Leu Ser Glu 
225                 230                 235                 240 


Pro Val Thr Met Asp Lys Val His Tyr Cys Glu Arg Phe Ile Glu Leu 
                245                 250                 255     


Met Ile Asp Leu Glu Ala Leu Leu Pro Thr Arg Arg Trp Phe Asn Thr 
            260                 265                 270         


Ile Leu Asp Asp Ser His Leu Leu Val His Cys Tyr Leu Ser Asn Leu 
        275                 280                 285             


Val Arg Arg Glu Glu Asp Gly His Leu Phe Ser Gln Leu Leu Asp Met 
    290                 295                 300                 


Leu Lys Phe Tyr Thr Gly Phe Glu Ile Asn Asp Gln Thr Gly Asn Ala 
305                 310                 315                 320 


Leu Thr Glu Asn Glu Met Thr Thr Ile His Tyr Asp Arg Ile Thr Ser 
                325                 330                 335     


Leu Gln Arg Ala Ala Phe Ala His Phe Pro Glu Leu Tyr Asp Phe Ala 
            340                 345                 350         


Leu Ser Asn Val Ala Glu Val Asp Thr Arg Glu Ser Leu Val Lys Phe 
        355                 360                 365             


Phe Gly Pro Leu Ser Ser Asn Thr Leu His Gln Val Ala Ser Tyr Leu 
    370                 375                 380                 


Cys Leu Leu Pro Thr Leu Pro Lys Asn Glu Asp Thr Thr Phe Asp Lys 
385                 390                 395                 400 


Glu Phe Leu Leu Glu Leu Leu Val Ser Arg His Glu Arg Arg Ile Ser 
                405                 410                 415     


Gln Ile Gln Gln Leu Asn Gln Met Pro Leu Tyr Pro Thr Glu Lys Ile 
            420                 425                 430         


Ile Trp Asp Glu Asn Ile Val Pro Thr Glu Tyr Tyr Ser Gly Glu Gly 
        435                 440                 445             


Cys Leu Ala Leu Pro Lys Leu Asn Leu Gln Phe Leu Thr Leu His Asp 
    450                 455                 460                 


Tyr Leu Leu Arg Asn Phe Asn Leu Phe Arg Leu Glu Ser Thr Tyr Glu 
465                 470                 475                 480 


Ile Arg Gln Asp Ile Glu Asp Ser Val Ser Arg Met Lys Pro Trp Gln 
                485                 490                 495     


Ser Glu Tyr Gly Gly Val Val Phe Gly Gly Trp Ala Arg Met Ala Gln 
            500                 505                 510         


Pro Ile Val Ala Phe Thr Val Val Glu Val Ala Lys Pro Asn Ile Gly 
        515                 520                 525             


Glu Asn Trp Pro Thr Arg Val Arg Ala Asp Val Thr Ile Asn Leu Asn 
    530                 535                 540                 


Val Arg Asp His Ile Lys Asp Glu Trp Glu Gly Leu Arg Lys His Asp 
545                 550                 555                 560 


Val Cys Phe Leu Ile Thr Val Arg Pro Thr Lys Pro Tyr Gly Thr Lys 
                565                 570                 575     


Phe Asp Arg Arg Arg Pro Phe Ile Glu Gln Val Gly Leu Val Tyr Val 
            580                 585                 590         


Arg Gly Cys Glu Ile Gln Gly Met Leu Asp Asp Lys Gly Arg Val Ile 
        595                 600                 605             


Glu Asp Gly Pro Glu Pro Arg Pro Asn Leu Arg Gly Glu Ser Arg Thr 
    610                 615                 620                 


Phe Arg Val Phe Leu Asp Pro Asn Gln Tyr Gln Gln Asp Met Thr Asn 
625                 630                 635                 640 


Thr Ile Gln Asn Gly Ala Glu Asp Val Tyr Glu Thr Phe Asn Ile Ile 
                645                 650                 655     


Met Arg Arg Lys Pro Lys Glu Asn Asn Phe Lys Ala Val Leu Glu Thr 
            660                 665                 670         


Ile Arg Asn Leu Met Asn Thr Asp Cys Val Val Pro Asp Trp Leu His 
        675                 680                 685             


Asp Ile Ile Leu Gly Tyr Gly Asp Pro Ser Ser Ala His Tyr Ser Lys 
    690                 695                 700                 


Met Pro Asn Gln Ile Ala Thr Leu Asp Phe Asn Asp Thr Phe Leu Ser 
705                 710                 715                 720 


Ile Glu His Leu Lys Ala Ser Phe Pro Gly His Asn Val Lys Val Thr 
                725                 730                 735     


Val Glu Asp Pro Ala Leu Gln Ile Pro Pro Phe Arg Ile Thr Phe Pro 
            740                 745                 750         


Val Arg Ser Gly Lys Gly Lys Lys Arg Lys Asp Ala Asp Val Glu Asp 
        755                 760                 765             


Glu Asp Thr Glu Glu Ala Lys Thr Leu Ile Val Glu Pro His Val Ile 
    770                 775                 780                 


Pro Asn Arg Gly Pro Tyr Pro Tyr Asn Gln Pro Lys Arg Asn Thr Ile 
785                 790                 795                 800 


Gln Phe Thr His Thr Gln Ile Glu Ala Ile Arg Ala Gly Met Gln Pro 
                805                 810                 815     


Gly Leu Thr Met Val Val Gly Pro Pro Gly Thr Gly Lys Thr Asp Val 
            820                 825                 830         


Ala Val Gln Ile Ile Ser Asn Ile Tyr His Asn Phe Pro Glu Gln Arg 
        835                 840                 845             


Thr Leu Ile Val Thr His Ser Asn Gln Ala Leu Asn Gln Leu Phe Glu 
    850                 855                 860                 


Lys Ile Met Ala Leu Asp Ile Asp Glu Arg His Leu Leu Arg Leu Gly 
865                 870                 875                 880 


His Gly Glu Glu Glu Leu Glu Thr Glu Lys Asp Phe Ser Arg Tyr Gly 
                885                 890                 895     


Arg Val Asn Tyr Val Leu Ala Arg Arg Ile Glu Leu Leu Glu Glu Val 
            900                 905                 910         


Lys Arg Leu Gln Lys Ser Leu Gly Val Pro Gly Asp Ala Ser Tyr Thr 
        915                 920                 925             


Cys Glu Thr Ala Gly Tyr Phe Phe Leu Tyr Gln Val Met Ser Arg Trp 
    930                 935                 940                 


Glu Glu Tyr Ile Ser Lys Val Lys Asn Lys Gly Ser Thr Leu Pro Asp 
945                 950                 955                 960 


Val Thr Glu Val Ser Thr Phe Phe Pro Phe His Glu Tyr Phe Ala Asn 
                965                 970                 975     


Ala Pro Gln Pro Ile Phe Lys Gly Arg Ser Tyr Glu Glu Asp Met Glu 
            980                 985                 990         


Ile Ala Glu Gly Cys Phe Arg His  Ile Lys Lys Ile Phe  Thr Gln Leu 
        995                 1000                 1005             


Glu Glu  Phe Arg Ala Ser Glu  Leu Leu Arg Ser Gly  Leu Asp Arg 
    1010                 1015                 1020             


Ser Lys  Tyr Leu Leu Val Lys  Glu Ala Lys Ile Ile  Ala Met Thr 
    1025                 1030                 1035             


Cys Thr  His Ala Ala Leu Lys  Arg His Asp Leu Val  Lys Leu Gly 
    1040                 1045                 1050             


Phe Lys  Tyr Asp Asn Ile Leu  Met Glu Glu Ala Ala  Gln Ile Leu 
    1055                 1060                 1065             


Glu Ile  Glu Thr Phe Ile Pro  Leu Leu Leu Gln Asn  Pro Gln Asp 
    1070                 1075                 1080             


Gly Phe  Ser Arg Leu Lys Arg  Trp Ile Met Ile Gly  Asp His His 
    1085                 1090                 1095             


Gln Leu  Pro Pro Val Ile Lys  Asn Met Ala Phe Gln  Lys Tyr Ser 
    1100                 1105                 1110             


Asn Met  Glu Gln Ser Leu Phe  Thr Arg Phe Val Arg  Val Gly Val 
    1115                 1120                 1125             


Pro Thr  Val Asp Leu Asp Ala  Gln Gly Arg Ala Arg  Ala Ser Leu 
    1130                 1135                 1140             


Cys Asn  Leu Tyr Asn Trp Arg  Tyr Lys Asn Leu Gly  Asn Leu Pro 
    1145                 1150                 1155             


His Val  Gln Leu Leu Pro Glu  Phe Ser Thr Ala Asn  Ala Gly Leu 
    1160                 1165                 1170             


Leu Tyr  Asp Phe Gln Leu Ile  Asn Val Glu Asp Phe  Gln Gly Val 
    1175                 1180                 1185             


Gly Glu  Ser Glu Pro Asn Pro  Tyr Phe Tyr Gln Asn  Leu Gly Glu 
    1190                 1195                 1200             


Ala Glu  Tyr Val Val Ala Leu  Phe Met Tyr Met Cys  Leu Leu Gly 
    1205                 1210                 1215             


Tyr Pro  Ala Asp Lys Ile Ser  Ile Leu Thr Thr Tyr  Asn Gly Gln 
    1220                 1225                 1230             


Lys His  Leu Ile Arg Asp Ile  Ile Asn Arg Arg Cys  Gly Asn Asn 
    1235                 1240                 1245             


Pro Leu  Ile Gly Arg Pro Asn  Lys Val Thr Thr Val  Asp Arg Phe 
    1250                 1255                 1260             


Gln Gly  Gln Gln Asn Asp Tyr  Ile Leu Leu Ser Leu  Val Arg Thr 
    1265                 1270                 1275             


Arg Ala  Val Gly His Leu Arg  Asp Val Arg Arg Leu  Val Val Ala 
    1280                 1285                 1290             


Met Ser  Arg Ala Arg Leu Gly  Leu Tyr Ile Phe Ala  Arg Val Ser 
    1295                 1300                 1305             


Leu Phe  Gln Asn Cys Phe Glu  Leu Thr Pro Ala Phe  Ser Gln Leu 
    1310                 1315                 1320             


Thr Ala  Arg Pro Leu His Leu  His Ile Ile Pro Thr  Glu Pro Phe 
    1325                 1330                 1335             


Pro Thr  Thr Arg Lys Asn Gly  Glu Arg Pro Ser His  Glu Val Gln 
    1340                 1345                 1350             


Ile Ile  Lys Asn Met Pro Gln  Met Ala Asn Phe Val  Tyr Asn Met 
    1355                 1360                 1365             


Tyr Met  His Leu Ile Gln Thr  Thr His His Tyr His  Gln Thr Leu 
    1370                 1375                 1380             


Leu Gln  Leu Pro Pro Ala Met  Val Glu Glu Gly Glu  Glu Val Gln 
    1385                 1390                 1395             


Asn Gln  Glu Thr Glu Leu Glu  Thr Glu Glu Glu Ala  Met Thr Val 
    1400                 1405                 1410             


Gln Ala  Asp Ile Ile Pro Ser  Pro Thr Asp Thr Ser  Cys Arg Gln 
    1415                 1420                 1425             


Glu Thr  Pro Ala Phe Gln Thr  Asp Thr Thr Pro Ser  Glu Thr Gly 
    1430                 1435                 1440             


Ala Thr  Ser Thr Pro Glu Ala  Ile Pro Ala Leu Ser  Glu Thr Thr 
    1445                 1450                 1455             


Pro Thr  Val Val Gly Ala Val  Ser Ala Pro Ala Glu  Ala Asn Thr 
    1460                 1465                 1470             


Pro Gln  Asp Ala Thr Ser Ala  Pro Glu Glu Thr Lys  
    1475                 1480                 1485 

<210>  3143
<211>  5124
<212>  DNA
<213>  Homo sapiens

<400>  3143
aacgcctgca tgaacttccg gctacacgcc attccgcttc ccgaggaacg cttgggctgt     60

tgtacgggtt ccctacggga ctctgaaggc tgaggatatc cggcccggag cgtttgtgcg    120

gcgcggagtt aagcgccccg gcagtaactt aagggaagtg gaccagggtt gccgctgccc    180

agagcggtcc tttagtttcc actggagtgg agggaagagt gctgccatgg cagcccctgc    240

gcagcccaag aagatcgtgg cccctacggt gtcccaaatc aatgcggagt tcgtgaccca    300

gttagcatgt aaatactggg ctccccacat caagaagaaa tcaccttttg atataaaggt    360

tattgaagat atatatgaaa aagagattgt caaatcaagg tttgctatta gaaagataat    420

gctcttggaa tttagccagt atcttgaaaa ttatctctgg atgaattatt ctcctgaggt    480

atctagcaag gcctatttaa tgtcaatctg ctgtatggtg aatgagaagt ttagagaaaa    540

cgtgcctgca tgggagattt ttaagaagaa gccagaccac ttcccattct tttttaaaca    600

catcttgaag gcggcattag ctgaaactga tggtgaattt tcacttcatg aacagacagt    660

cttactactt tttcttgatc attgcttcaa tagtttggaa gtagacttga tacgaagtca    720

agtacagcag cttatctccc tcccaatgtg gatgggctta cagctggcac gattggaatt    780

agaattaaaa aagacaccta agctaagaaa attctggaac ttgattaaaa agaatgatga    840

aaagatggat ccagaagcaa gagaacaggc atatcaagag aggagatttc tttcacaact    900

catccagaag tttatctctg tgctgaaatc agtcccactt tctgaacctg tcactatgga    960

caaagttcat tactgtgaaa gattcattga acttatgatt gatctagagg ccctgctacc   1020

cacaaggcgc tggtttaata ccatcctgga tgattcccac cttctggttc actgttacct   1080

ttccaatctt gttcgtagag aagaggatgg ccatcttttt tcccagcttt tggacatgct   1140

taaattctat actggttttg aaattaatga ccaaactgga aatgctctga cagagaatga   1200

gatgaccaca attcactatg atagaattac ttctctacag agagctgctt ttgcacattt   1260

tcctgaactc tatgattttg ccctctcaaa tgtggcagaa gtagatactc gggagtcctt   1320

ggtcaagttt tttggacctc ttagttcaaa cacactccac caggtggcat catacctctg   1380

cttgttgcca actcttccta aaaatgaaga cacaactttt gataaagaat ttcttctaga   1440

attgctggta tctcgtcatg aacgtcgaat ttctcagatt cagcagttga accagatgcc   1500

tttgtatcca actgagaaaa ttatatggga tgaaaatatt gtcccaactg agtactattc   1560

tggagaaggt tgtcttgctc ttcccaaatt gaatttgcag tttttgactc ttcatgacta   1620

cctgctaagg aactttaacc tcttccgctt agaatcaact tatgaaattc gtcaggacat   1680

tgaagatagt gtcagcagaa tgaagccatg gcaatctgaa tatggcggtg tagtgtttgg   1740

tggttgggcg cgaatggccc agcccattgt ggctttcact gtcgttgaag tggccaaacc   1800

caacataggt gaaaactggc caacccgagt tcgtgcagat gttaccataa atctcaatgt   1860

cagagatcac atcaaagatg aatgggaagg tcttcgtaag catgatgtat gctttttaat   1920

taccgtacgt cccacaaaac cttatggcac taagtttgac cggaggagac cttttattga   1980

gcaggttggc ctggtttatg tcagaggctg tgaaattcag ggcatgctgg atgataaagg   2040

acgtgtcatt gaagatggac ctgaacccag acccaatctt agaggagaat caaggacatt   2100

tagagtgttt ttggatccaa accagtatca acaagatatg accaatacta tacaaaatgg   2160

agcagaggat gtgtatgaaa cttttaatat aataatgagg agaaaaccaa aggaaaataa   2220

ctttaaggct gtgctggaga ctattcggaa cctgatgaat actgattgtg tggtacctga   2280

ctggctgcac gatatcattt taggttatgg ggacccaagt agtgcacatt attcgaaaat   2340

gcccaatcag attgccaccc ttgatttcaa tgatacattt ctctccattg agcatttaaa   2400

agccagcttc cctggtcata atgttaaagt aactgtagaa gaccctgctc tacaaatacc   2460

ccctttcagg ataacttttc cagtaagaag tggaaaaggg aagaaaagga aagatgcgga   2520

tgtggaagat gaagacaccg aggaagcaaa aaccttaatt gttgagcccc atgttattcc   2580

taataggggt ccttatcctt ataatcaacc caaacgtaat acgattcagt tcactcatac   2640

acagatagaa gccatccgtg ctggaatgca gcctgggctg actatggttg tgggcccacc   2700

tggtacaggc aaaacagatg tggcagttca gatcatatcc aacatctacc acaacttccc   2760

agaacagagg actctaattg ttactcattc caatcaggcc ctaaaccagt tgtttgagaa   2820

aatcatggca ttagacattg atgagcgcca cctactgcgt cttggtcatg gagaagaaga   2880

gctggagaca gagaaagatt tcagcaggta tggaagagtt aattatgttc tggctcgaag   2940

aatagaactt ttagaagaag tcaaacgatt gcaaaagagt ctaggggttc caggagatgc   3000

ctcatatacc tgtgaaactg caggctattt cttcttatac caggtaatgt ctcgctggga   3060

agagtatatc agcaaagtga aaaataaagg tagtacattg ccagatgtta cggaagtctc   3120

cactttcttc cctttccatg aatactttgc aaatgctcct caacccattt ttaaaggaag   3180

atcttatgaa gaagacatgg aaattgctga aggatgtttc aggcatatta agaaaatctt   3240

tacgcagctt gaggaattca gagcctctga attgcttcga agtggactgg acagatctaa   3300

atacctttta gtgaaagaag ccaaaattat tgctatgacc tgtactcatg ctgccttaaa   3360

acgacatgac ttggtcaagc taggtttcaa gtatgacaac attttgatgg aagaggctgc   3420

tcagattctg gagatagaaa cttttatccc tcttcttcta cagaatcctc aggatggatt   3480

tagccgacta aaacgatgga ttatgattgg cgatcatcac cagttacctc cagttattaa   3540

gaacatggcc tttcaaaagt actcaaacat ggagcagtct ctcttcactc gctttgttcg   3600

cgttggagtt ccgactgttg accttgatgc tcaagggaga gccagagcaa gcttgtgcaa   3660

cctctacaac tggcgataca agaatctagg aaacttaccc catgtgcagc tcttgccaga   3720

gtttagtaca gcaaatgctg gcttactgta tgacttccag ctcattaatg ttgaagattt   3780

tcaaggagtg ggagaatctg aacctaatcc ttacttctat cagaatcttg gagaggcaga   3840

atatgtagta gcacttttta tgtacatgtg tttacttggt taccctgctg acaaaatcag   3900

tattctaaca acatataatg gccaaaagca tcttattcgc gacatcatca atagacgatg   3960

tggaaacaat ccattgattg gaagaccaaa caaggtgaca actgttgata gatttcaagg   4020

tcaacagaat gactatattc ttctttctct ggtacgaacc agggcagtgg gccatctgag   4080

ggatgtccgt cgcttggtag tggccatgtc tagagccaga cttggacttt atatcttcgc   4140

cagagtatcc ctcttccaaa actgttttga actgactcca gctttcagtc agctcacagc   4200

tcgccccctt catttgcata taattccaac agaacctttc ccaactacta gaaagaatgg   4260

agagagacca tctcatgaag tacaaataat aaaaaatatg ccccagatgg caaactttgt   4320

atacaacatg tacatgcatt tgatacagac tacacatcat tatcatcaga ctttattaca   4380

actaccacct gctatggtag aagagggtga ggaagttcaa aatcaagaaa cagaattgga   4440

aacagaagaa gaggccatga ctgttcaagc tgacatcata cccagtccaa cagacaccag   4500

ctgccgtcaa gaaactccag cctttcaaac tgacaccacc cccagtgaga caggagccac   4560

ttccactcca gaagccatcc ctgctttatc tgagaccacc cctactgtgg taggagctgt   4620

atctgcaccg gcagaagcta acacacctca ggatgccaca tctgccccgg aagagaccaa   4680

gtagccaaac tgtagtcctt ctaaaggagg acatggcagt caaaaagtct gagtaaagct   4740

gttttttgta ttttatattt gcttctgcca ttttactgtc actaattaat gtttagttct   4800

tatatttgtt aactgatttc ggtgtcttga atatattttt ttaaattatg tgtatgaaca   4860

attctagttt catttgttca atcagaagag caaataacca ttcctttcat gttttgatca   4920

ctgagtgtgt ctgtaatcat acctacatta aaatcatttt ctatgaatat ataatatata   4980

cttcacattt ttagtgaact tctctaaaga agaggacaga atatactgga cttaaccacg   5040

aatacccttg agtgtccaaa ttgggaagga acttgtttct tctgttatac tatcaaatgc   5100

ttaaattctg tttccttttt tctt                                          5124


<210>  3144
<211>  1485
<212>  PRT
<213>  Homo sapiens

<400>  3144


Met Ala Ala Pro Ala Gln Pro Lys Lys Ile Val Ala Pro Thr Val Ser 
1               5                   10                  15      


Gln Ile Asn Ala Glu Phe Val Thr Gln Leu Ala Cys Lys Tyr Trp Ala 
            20                  25                  30          


Pro His Ile Lys Lys Lys Ser Pro Phe Asp Ile Lys Val Ile Glu Asp 
        35                  40                  45              


Ile Tyr Glu Lys Glu Ile Val Lys Ser Arg Phe Ala Ile Arg Lys Ile 
    50                  55                  60                  


Met Leu Leu Glu Phe Ser Gln Tyr Leu Glu Asn Tyr Leu Trp Met Asn 
65                  70                  75                  80  


Tyr Ser Pro Glu Val Ser Ser Lys Ala Tyr Leu Met Ser Ile Cys Cys 
                85                  90                  95      


Met Val Asn Glu Lys Phe Arg Glu Asn Val Pro Ala Trp Glu Ile Phe 
            100                 105                 110         


Lys Lys Lys Pro Asp His Phe Pro Phe Phe Phe Lys His Ile Leu Lys 
        115                 120                 125             


Ala Ala Leu Ala Glu Thr Asp Gly Glu Phe Ser Leu His Glu Gln Thr 
    130                 135                 140                 


Val Leu Leu Leu Phe Leu Asp His Cys Phe Asn Ser Leu Glu Val Asp 
145                 150                 155                 160 


Leu Ile Arg Ser Gln Val Gln Gln Leu Ile Ser Leu Pro Met Trp Met 
                165                 170                 175     


Gly Leu Gln Leu Ala Arg Leu Glu Leu Glu Leu Lys Lys Thr Pro Lys 
            180                 185                 190         


Leu Arg Lys Phe Trp Asn Leu Ile Lys Lys Asn Asp Glu Lys Met Asp 
        195                 200                 205             


Pro Glu Ala Arg Glu Gln Ala Tyr Gln Glu Arg Arg Phe Leu Ser Gln 
    210                 215                 220                 


Leu Ile Gln Lys Phe Ile Ser Val Leu Lys Ser Val Pro Leu Ser Glu 
225                 230                 235                 240 


Pro Val Thr Met Asp Lys Val His Tyr Cys Glu Arg Phe Ile Glu Leu 
                245                 250                 255     


Met Ile Asp Leu Glu Ala Leu Leu Pro Thr Arg Arg Trp Phe Asn Thr 
            260                 265                 270         


Ile Leu Asp Asp Ser His Leu Leu Val His Cys Tyr Leu Ser Asn Leu 
        275                 280                 285             


Val Arg Arg Glu Glu Asp Gly His Leu Phe Ser Gln Leu Leu Asp Met 
    290                 295                 300                 


Leu Lys Phe Tyr Thr Gly Phe Glu Ile Asn Asp Gln Thr Gly Asn Ala 
305                 310                 315                 320 


Leu Thr Glu Asn Glu Met Thr Thr Ile His Tyr Asp Arg Ile Thr Ser 
                325                 330                 335     


Leu Gln Arg Ala Ala Phe Ala His Phe Pro Glu Leu Tyr Asp Phe Ala 
            340                 345                 350         


Leu Ser Asn Val Ala Glu Val Asp Thr Arg Glu Ser Leu Val Lys Phe 
        355                 360                 365             


Phe Gly Pro Leu Ser Ser Asn Thr Leu His Gln Val Ala Ser Tyr Leu 
    370                 375                 380                 


Cys Leu Leu Pro Thr Leu Pro Lys Asn Glu Asp Thr Thr Phe Asp Lys 
385                 390                 395                 400 


Glu Phe Leu Leu Glu Leu Leu Val Ser Arg His Glu Arg Arg Ile Ser 
                405                 410                 415     


Gln Ile Gln Gln Leu Asn Gln Met Pro Leu Tyr Pro Thr Glu Lys Ile 
            420                 425                 430         


Ile Trp Asp Glu Asn Ile Val Pro Thr Glu Tyr Tyr Ser Gly Glu Gly 
        435                 440                 445             


Cys Leu Ala Leu Pro Lys Leu Asn Leu Gln Phe Leu Thr Leu His Asp 
    450                 455                 460                 


Tyr Leu Leu Arg Asn Phe Asn Leu Phe Arg Leu Glu Ser Thr Tyr Glu 
465                 470                 475                 480 


Ile Arg Gln Asp Ile Glu Asp Ser Val Ser Arg Met Lys Pro Trp Gln 
                485                 490                 495     


Ser Glu Tyr Gly Gly Val Val Phe Gly Gly Trp Ala Arg Met Ala Gln 
            500                 505                 510         


Pro Ile Val Ala Phe Thr Val Val Glu Val Ala Lys Pro Asn Ile Gly 
        515                 520                 525             


Glu Asn Trp Pro Thr Arg Val Arg Ala Asp Val Thr Ile Asn Leu Asn 
    530                 535                 540                 


Val Arg Asp His Ile Lys Asp Glu Trp Glu Gly Leu Arg Lys His Asp 
545                 550                 555                 560 


Val Cys Phe Leu Ile Thr Val Arg Pro Thr Lys Pro Tyr Gly Thr Lys 
                565                 570                 575     


Phe Asp Arg Arg Arg Pro Phe Ile Glu Gln Val Gly Leu Val Tyr Val 
            580                 585                 590         


Arg Gly Cys Glu Ile Gln Gly Met Leu Asp Asp Lys Gly Arg Val Ile 
        595                 600                 605             


Glu Asp Gly Pro Glu Pro Arg Pro Asn Leu Arg Gly Glu Ser Arg Thr 
    610                 615                 620                 


Phe Arg Val Phe Leu Asp Pro Asn Gln Tyr Gln Gln Asp Met Thr Asn 
625                 630                 635                 640 


Thr Ile Gln Asn Gly Ala Glu Asp Val Tyr Glu Thr Phe Asn Ile Ile 
                645                 650                 655     


Met Arg Arg Lys Pro Lys Glu Asn Asn Phe Lys Ala Val Leu Glu Thr 
            660                 665                 670         


Ile Arg Asn Leu Met Asn Thr Asp Cys Val Val Pro Asp Trp Leu His 
        675                 680                 685             


Asp Ile Ile Leu Gly Tyr Gly Asp Pro Ser Ser Ala His Tyr Ser Lys 
    690                 695                 700                 


Met Pro Asn Gln Ile Ala Thr Leu Asp Phe Asn Asp Thr Phe Leu Ser 
705                 710                 715                 720 


Ile Glu His Leu Lys Ala Ser Phe Pro Gly His Asn Val Lys Val Thr 
                725                 730                 735     


Val Glu Asp Pro Ala Leu Gln Ile Pro Pro Phe Arg Ile Thr Phe Pro 
            740                 745                 750         


Val Arg Ser Gly Lys Gly Lys Lys Arg Lys Asp Ala Asp Val Glu Asp 
        755                 760                 765             


Glu Asp Thr Glu Glu Ala Lys Thr Leu Ile Val Glu Pro His Val Ile 
    770                 775                 780                 


Pro Asn Arg Gly Pro Tyr Pro Tyr Asn Gln Pro Lys Arg Asn Thr Ile 
785                 790                 795                 800 


Gln Phe Thr His Thr Gln Ile Glu Ala Ile Arg Ala Gly Met Gln Pro 
                805                 810                 815     


Gly Leu Thr Met Val Val Gly Pro Pro Gly Thr Gly Lys Thr Asp Val 
            820                 825                 830         


Ala Val Gln Ile Ile Ser Asn Ile Tyr His Asn Phe Pro Glu Gln Arg 
        835                 840                 845             


Thr Leu Ile Val Thr His Ser Asn Gln Ala Leu Asn Gln Leu Phe Glu 
    850                 855                 860                 


Lys Ile Met Ala Leu Asp Ile Asp Glu Arg His Leu Leu Arg Leu Gly 
865                 870                 875                 880 


His Gly Glu Glu Glu Leu Glu Thr Glu Lys Asp Phe Ser Arg Tyr Gly 
                885                 890                 895     


Arg Val Asn Tyr Val Leu Ala Arg Arg Ile Glu Leu Leu Glu Glu Val 
            900                 905                 910         


Lys Arg Leu Gln Lys Ser Leu Gly Val Pro Gly Asp Ala Ser Tyr Thr 
        915                 920                 925             


Cys Glu Thr Ala Gly Tyr Phe Phe Leu Tyr Gln Val Met Ser Arg Trp 
    930                 935                 940                 


Glu Glu Tyr Ile Ser Lys Val Lys Asn Lys Gly Ser Thr Leu Pro Asp 
945                 950                 955                 960 


Val Thr Glu Val Ser Thr Phe Phe Pro Phe His Glu Tyr Phe Ala Asn 
                965                 970                 975     


Ala Pro Gln Pro Ile Phe Lys Gly Arg Ser Tyr Glu Glu Asp Met Glu 
            980                 985                 990         


Ile Ala Glu Gly Cys Phe Arg His  Ile Lys Lys Ile Phe  Thr Gln Leu 
        995                 1000                 1005             


Glu Glu  Phe Arg Ala Ser Glu  Leu Leu Arg Ser Gly  Leu Asp Arg 
    1010                 1015                 1020             


Ser Lys  Tyr Leu Leu Val Lys  Glu Ala Lys Ile Ile  Ala Met Thr 
    1025                 1030                 1035             


Cys Thr  His Ala Ala Leu Lys  Arg His Asp Leu Val  Lys Leu Gly 
    1040                 1045                 1050             


Phe Lys  Tyr Asp Asn Ile Leu  Met Glu Glu Ala Ala  Gln Ile Leu 
    1055                 1060                 1065             


Glu Ile  Glu Thr Phe Ile Pro  Leu Leu Leu Gln Asn  Pro Gln Asp 
    1070                 1075                 1080             


Gly Phe  Ser Arg Leu Lys Arg  Trp Ile Met Ile Gly  Asp His His 
    1085                 1090                 1095             


Gln Leu  Pro Pro Val Ile Lys  Asn Met Ala Phe Gln  Lys Tyr Ser 
    1100                 1105                 1110             


Asn Met  Glu Gln Ser Leu Phe  Thr Arg Phe Val Arg  Val Gly Val 
    1115                 1120                 1125             


Pro Thr  Val Asp Leu Asp Ala  Gln Gly Arg Ala Arg  Ala Ser Leu 
    1130                 1135                 1140             


Cys Asn  Leu Tyr Asn Trp Arg  Tyr Lys Asn Leu Gly  Asn Leu Pro 
    1145                 1150                 1155             


His Val  Gln Leu Leu Pro Glu  Phe Ser Thr Ala Asn  Ala Gly Leu 
    1160                 1165                 1170             


Leu Tyr  Asp Phe Gln Leu Ile  Asn Val Glu Asp Phe  Gln Gly Val 
    1175                 1180                 1185             


Gly Glu  Ser Glu Pro Asn Pro  Tyr Phe Tyr Gln Asn  Leu Gly Glu 
    1190                 1195                 1200             


Ala Glu  Tyr Val Val Ala Leu  Phe Met Tyr Met Cys  Leu Leu Gly 
    1205                 1210                 1215             


Tyr Pro  Ala Asp Lys Ile Ser  Ile Leu Thr Thr Tyr  Asn Gly Gln 
    1220                 1225                 1230             


Lys His  Leu Ile Arg Asp Ile  Ile Asn Arg Arg Cys  Gly Asn Asn 
    1235                 1240                 1245             


Pro Leu  Ile Gly Arg Pro Asn  Lys Val Thr Thr Val  Asp Arg Phe 
    1250                 1255                 1260             


Gln Gly  Gln Gln Asn Asp Tyr  Ile Leu Leu Ser Leu  Val Arg Thr 
    1265                 1270                 1275             


Arg Ala  Val Gly His Leu Arg  Asp Val Arg Arg Leu  Val Val Ala 
    1280                 1285                 1290             


Met Ser  Arg Ala Arg Leu Gly  Leu Tyr Ile Phe Ala  Arg Val Ser 
    1295                 1300                 1305             


Leu Phe  Gln Asn Cys Phe Glu  Leu Thr Pro Ala Phe  Ser Gln Leu 
    1310                 1315                 1320             


Thr Ala  Arg Pro Leu His Leu  His Ile Ile Pro Thr  Glu Pro Phe 
    1325                 1330                 1335             


Pro Thr  Thr Arg Lys Asn Gly  Glu Arg Pro Ser His  Glu Val Gln 
    1340                 1345                 1350             


Ile Ile  Lys Asn Met Pro Gln  Met Ala Asn Phe Val  Tyr Asn Met 
    1355                 1360                 1365             


Tyr Met  His Leu Ile Gln Thr  Thr His His Tyr His  Gln Thr Leu 
    1370                 1375                 1380             


Leu Gln  Leu Pro Pro Ala Met  Val Glu Glu Gly Glu  Glu Val Gln 
    1385                 1390                 1395             


Asn Gln  Glu Thr Glu Leu Glu  Thr Glu Glu Glu Ala  Met Thr Val 
    1400                 1405                 1410             


Gln Ala  Asp Ile Ile Pro Ser  Pro Thr Asp Thr Ser  Cys Arg Gln 
    1415                 1420                 1425             


Glu Thr  Pro Ala Phe Gln Thr  Asp Thr Thr Pro Ser  Glu Thr Gly 
    1430                 1435                 1440             


Ala Thr  Ser Thr Pro Glu Ala  Ile Pro Ala Leu Ser  Glu Thr Thr 
    1445                 1450                 1455             


Pro Thr  Val Val Gly Ala Val  Ser Ala Pro Ala Glu  Ala Asn Thr 
    1460                 1465                 1470             


Pro Gln  Asp Ala Thr Ser Ala  Pro Glu Glu Thr Lys  
    1475                 1480                 1485 

<210>  3145
<211>  5801
<212>  DNA
<213>  Homo sapiens

<400>  3145
aacgcctgca tgaacttccg gctacacgcc attccgcttc ccgaggaacg cttgggctgt     60

tgtacgggtt ccctacggga ctctgaaggc tgaggatatc cggcccggag cgtttgtgcg    120

gcgcggagtt aagcgccccg gcagtaactt aagggaagtg gaccagggtt gccgctgccc    180

agagcggtcc tttagtttcc actggagtgg agggaagagt gctgccatgg cagcccctgc    240

gcagcccaag aagatcgtgg cccctacggt gtcccaaatc aatgcggagt tcgtgaccca    300

gttagcatgt aaatactggg ctccccacat caagaagaaa tcaccttttg atataaaggt    360

tattgaagat atatatgaaa aagagattgt caaatcaagg tttgctatta gaaagataat    420

gctcttggaa tttagccagt atcttgaaaa ttatctctgg atgaattatt ctcctgaggt    480

atctagcaag gcctatttaa tgtcaatctg ctgtatggtg aatgagaagt ttagagaaaa    540

cgtgcctgca tgggagattt ttaagaagaa gccagaccac ttcccattct tttttaaaca    600

catcttgaag gcggcattag ctgaaactga tggtgaattt tcacttcatg aacagacagt    660

cttactactt tttcttgatc attgcttcaa tagtttggaa gtagacttga tacgaagtca    720

agtacagcag cttatctccc tcccaatgtg gatgggctta cagctggcac gattggaatt    780

agaattaaaa aagacaccta agctaagaaa attctggaac ttgattaaaa agaatgatga    840

aaagatggat ccagaagcaa gagaacaggc atatcaagag aggagatttc tttcacaact    900

catccagaag tttatctctg tgctgaaatc agtcccactt tctgaacctg tcactatgga    960

caaagttcat tactgtgaaa gattcattga acttatgatt gatctagagg ccctgctacc   1020

cacaaggcgc tggtttaata ccatcctgga tgattcccac cttctggttc actgttacct   1080

ttccaatctt gttcgtagag aagaggatgg ccatcttttt tcccagcttt tggacatgct   1140

taaattctat actggttttg aaattaatga ccaaactgga aatgctctga cagagaatga   1200

gatgaccaca attcactatg atagaattac ttctctacag agagctgctt ttgcacattt   1260

tcctgaactc tatgattttg ccctctcaaa tgtggcagaa gtagatactc gggagtcctt   1320

ggtcaagttt tttggacctc ttagttcaaa cacactccac caggtggcat catacctctg   1380

cttgttgcca actcttccta aaaatgaaga cacaactttt gataaagaat ttcttctaga   1440

attgctggta tctcgtcatg aacgtcgaat ttctcagatt cagcagttga accagatgcc   1500

tttgtatcca actgagaaaa ttatatggga tgaaaatatt gtcccaactg agtactattc   1560

tggagaaggt tgtcttgctc ttcccaaatt gaatttgcag tttttgactc ttcatgacta   1620

cctgctaagg aactttaacc tcttccgctt agaatcaact tatgaaattc gtcaggacat   1680

tgaagatagt gtcagcagaa tgaagccatg gcaatctgaa tatggcggtg tagtgtttgg   1740

tggttgggcg cgaatggccc agcccattgt ggctttcact gtcgttgaag tggccaaacc   1800

caacataggt gaaaactggc caacccgagt tcgtgcagat gttaccataa atctcaatgt   1860

cagagatcac atcaaagatg aatgggaagg tcttcgtaag catgatgtat gctttttaat   1920

taccgtacgt cccacaaaac cttatggcac taagtttgac cggaggagac cttttattga   1980

gcaggttggc ctggtttatg tcagaggctg tgaaattcag ggcatgctgg atgataaagg   2040

acgtgtcatt gaagatggac ctgaacccag acccaatctt agaggagaat caaggacatt   2100

tagagtgttt ttggatccaa accagtatca acaagatatg accaatacta tacaaaatgg   2160

agcagaggat gtgtatgaaa cttttaatat aataatgagg agaaaaccaa aggaaaataa   2220

ctttaaggct gtgctggaga ctattcggaa cctgatgaat actgattgtg tggtacctga   2280

ctggctgcac gatatcattt taggttatgg ggacccaagt agtgcacatt attcgaaaat   2340

gcccaatcag attgccaccc ttgatttcaa tgatacattt ctctccattg agcatttaaa   2400

agccagcttc cctggtcata atgttaaagt aactgtagaa gaccctgctc tacaaatacc   2460

ccctttcagg ataacttttc cagtaagaag tggaaaaggg aagaaaagga aagatgcgga   2520

tgtggaagat gaagacaccg aggaagcaaa aaccttaatt gttgagcccc atgttattcc   2580

taataggggt ccttatcctt ataatcaacc caaacgtaat acgattcagt tcactcatac   2640

acagatagaa gccatccgtg ctggaatgca gcctgggctg actatggttg tgggcccacc   2700

tggtacaggc aaaacagatg tggcagttca gatcatatcc aacatctacc acaacttccc   2760

agaacagagg actctaattg ttactcattc caatcaggcc ctaaaccagt tgtttgagaa   2820

aatcatggca ttagacattg atgagcgcca cctactgcgt cttggtcatg gagaagaaga   2880

gctggagaca gagaaagatt tcagcaggta tggaagagtt aattatgttc tggctcgaag   2940

aatagaactt ttagaagaag tcaaacgatt gcaaaagagt ctaggggttc caggagatgc   3000

ctcatatacc tgtgaaactg caggctattt cttcttatac caggtaatgt ctcgctggga   3060

agagtatatc agcaaagtga aaaataaagg tagtacattg ccagatgtta cggaagtctc   3120

cactttcttc cctttccatg aatactttgc aaatgctcct caacccattt ttaaaggaag   3180

atcttatgaa gaagacatgg aaattgctga aggatgtttc aggcatatta agaaaatctt   3240

tacgcagctt gaggaattca gagcctctga attgcttcga agtggactgg acagatctaa   3300

atacctttta gtgaaagaag ccaaaattat tgctatgacc tgtactcatg ctgccttaaa   3360

acgacatgac ttggtcaagc taggtttcaa gtatgacaac attttgatgg aagaggctgc   3420

tcagattctg gagatagaaa cttttatccc tcttcttcta cagaatcctc aggatggatt   3480

tagccgacta aaacgatgga ttatgattgg cgatcatcac cagttacctc cagttattaa   3540

gaacatggcc tttcaaaagt actcaaacat ggagcagtct ctcttcactc gctttgttcg   3600

cgttggagtt ccgactgttg accttgatgc tcaagggaga gccagagcaa ggtaaaagag   3660

acaggaaaaa aaatcattcc catttaagga catttgttcc atgatccaag tatttgtgaa   3720

tagcttttgt gtagactatt agcattcttg gctatccagg aacttggcta tccataaatc   3780

caaaagcact tttgtcgact tctgcaagag atgtgaatgg accaaataat ttatttcctt   3840

catttcattc attaatatta atttaagtaa cttataatct aaaggcttct tttcattgtc   3900

ccttctcctt tcttcatgtc cccaaaagat atacagttaa tataatttta aaatctaaaa   3960

ataaagtgaa caagaggaga acacaccaat tcttacttca taaaggatgc aggccccatc   4020

tcatagttac ccccaaatgt cctcaatttt tagtcttcct tgatttttta atttaaggga   4080

taaagatagc attgacctca gagagcgtaa tagaactctc atttttgtag taccttcagt   4140

cttctgaccc ttggttactt gaagtaggga agctaaggtt gaaagagcat tattgcttaa   4200

aagatgagcc aaaatggcta acatgaaaat ttaaaagaag cacagaaaca gaaacctcct   4260

tatgtatatt aaaagagatt ttacactgct aatattttct gtttgtgggg gaatttgtct   4320

ttggaaagct tgtgcaacct ctacaactgg cgatacaaga atctaggaaa cttaccccat   4380

gtgcagctct tgccagagtt tagtacagca aatgctggct tactgtatga cttccagctc   4440

attaatgttg aagattttca aggagtggga gaatctgaac ctaatcctta cttctatcag   4500

aatcttggag aggcagaata tgtagtagca ctttttatgt acatgtgttt acttggttac   4560

cctgctgaca aaatcagtat tctaacaaca tataatggcc aaaagcatct tattcgcgac   4620

atcatcaata gacgatgtgg aaacaatcca ttgattggaa gaccaaacaa ggtgacaact   4680

gttgatagat ttcaaggtca acagaatgac tatattcttc tttctctggt acgaaccagg   4740

gcagtgggcc atctgaggga tgtccgtcgc ttggtagtgg ccatgtctag agccagactt   4800

ggactttata tcttcgccag agtatccctc ttccaaaact gttttgaact gactccagct   4860

ttcagtcagc tcacagctcg cccccttcat ttgcatataa ttccaacaga acctttccca   4920

actactagaa agaatggaga gagaccatct catgaagtac aaataataaa aaatatgccc   4980

cagatggcaa actttgtata caacatgtac atgcatttga tacagactac acatcattat   5040

catcagactt tattacaact accacctgct atggtagaag agggtgagga agttcaaaat   5100

caagaaacag aattggaaac agaagaagag gccatgactg ttcaagctga catcataccc   5160

agtccaacag acaccagctg ccgtcaagaa actccagcct ttcaaactga caccaccccc   5220

agtgagacag gagccacttc cactccagaa gccatccctg ctttatctga gaccacccct   5280

actgtggtag gagctgtatc tgcaccggca gaagctaaca cacctcagga tgccacatct   5340

gccccggaag agaccaagta gccaaactgt agtccttcta aaggaggaca tggcagtcaa   5400

aaagtctgag taaagctgtt ttttgtattt tatatttgct tctgccattt tactgtcact   5460

aattaatgtt tagttcttat atttgttaac tgatttcggt gtcttgaata tattttttta   5520

aattatgtgt atgaacaatt ctagtttcat ttgttcaatc agaagagcaa ataaccattc   5580

ctttcatgtt ttgatcactg agtgtgtctg taatcatacc tacattaaaa tcattttcta   5640

tgaatatata atatatactt cacattttta gtgaacttct ctaaagaaga ggacagaata   5700

tactggactt aaccacgaat acccttgagt gtccaaattg ggaaggaact tgtttcttct   5760

gttatactat caaatgctta aattctgttt ccttttttct t                       5801


<210>  3146
<211>  1142
<212>  PRT
<213>  Homo sapiens

<400>  3146


Met Ala Ala Pro Ala Gln Pro Lys Lys Ile Val Ala Pro Thr Val Ser 
1               5                   10                  15      


Gln Ile Asn Ala Glu Phe Val Thr Gln Leu Ala Cys Lys Tyr Trp Ala 
            20                  25                  30          


Pro His Ile Lys Lys Lys Ser Pro Phe Asp Ile Lys Val Ile Glu Asp 
        35                  40                  45              


Ile Tyr Glu Lys Glu Ile Val Lys Ser Arg Phe Ala Ile Arg Lys Ile 
    50                  55                  60                  


Met Leu Leu Glu Phe Ser Gln Tyr Leu Glu Asn Tyr Leu Trp Met Asn 
65                  70                  75                  80  


Tyr Ser Pro Glu Val Ser Ser Lys Ala Tyr Leu Met Ser Ile Cys Cys 
                85                  90                  95      


Met Val Asn Glu Lys Phe Arg Glu Asn Val Pro Ala Trp Glu Ile Phe 
            100                 105                 110         


Lys Lys Lys Pro Asp His Phe Pro Phe Phe Phe Lys His Ile Leu Lys 
        115                 120                 125             


Ala Ala Leu Ala Glu Thr Asp Gly Glu Phe Ser Leu His Glu Gln Thr 
    130                 135                 140                 


Val Leu Leu Leu Phe Leu Asp His Cys Phe Asn Ser Leu Glu Val Asp 
145                 150                 155                 160 


Leu Ile Arg Ser Gln Val Gln Gln Leu Ile Ser Leu Pro Met Trp Met 
                165                 170                 175     


Gly Leu Gln Leu Ala Arg Leu Glu Leu Glu Leu Lys Lys Thr Pro Lys 
            180                 185                 190         


Leu Arg Lys Phe Trp Asn Leu Ile Lys Lys Asn Asp Glu Lys Met Asp 
        195                 200                 205             


Pro Glu Ala Arg Glu Gln Ala Tyr Gln Glu Arg Arg Phe Leu Ser Gln 
    210                 215                 220                 


Leu Ile Gln Lys Phe Ile Ser Val Leu Lys Ser Val Pro Leu Ser Glu 
225                 230                 235                 240 


Pro Val Thr Met Asp Lys Val His Tyr Cys Glu Arg Phe Ile Glu Leu 
                245                 250                 255     


Met Ile Asp Leu Glu Ala Leu Leu Pro Thr Arg Arg Trp Phe Asn Thr 
            260                 265                 270         


Ile Leu Asp Asp Ser His Leu Leu Val His Cys Tyr Leu Ser Asn Leu 
        275                 280                 285             


Val Arg Arg Glu Glu Asp Gly His Leu Phe Ser Gln Leu Leu Asp Met 
    290                 295                 300                 


Leu Lys Phe Tyr Thr Gly Phe Glu Ile Asn Asp Gln Thr Gly Asn Ala 
305                 310                 315                 320 


Leu Thr Glu Asn Glu Met Thr Thr Ile His Tyr Asp Arg Ile Thr Ser 
                325                 330                 335     


Leu Gln Arg Ala Ala Phe Ala His Phe Pro Glu Leu Tyr Asp Phe Ala 
            340                 345                 350         


Leu Ser Asn Val Ala Glu Val Asp Thr Arg Glu Ser Leu Val Lys Phe 
        355                 360                 365             


Phe Gly Pro Leu Ser Ser Asn Thr Leu His Gln Val Ala Ser Tyr Leu 
    370                 375                 380                 


Cys Leu Leu Pro Thr Leu Pro Lys Asn Glu Asp Thr Thr Phe Asp Lys 
385                 390                 395                 400 


Glu Phe Leu Leu Glu Leu Leu Val Ser Arg His Glu Arg Arg Ile Ser 
                405                 410                 415     


Gln Ile Gln Gln Leu Asn Gln Met Pro Leu Tyr Pro Thr Glu Lys Ile 
            420                 425                 430         


Ile Trp Asp Glu Asn Ile Val Pro Thr Glu Tyr Tyr Ser Gly Glu Gly 
        435                 440                 445             


Cys Leu Ala Leu Pro Lys Leu Asn Leu Gln Phe Leu Thr Leu His Asp 
    450                 455                 460                 


Tyr Leu Leu Arg Asn Phe Asn Leu Phe Arg Leu Glu Ser Thr Tyr Glu 
465                 470                 475                 480 


Ile Arg Gln Asp Ile Glu Asp Ser Val Ser Arg Met Lys Pro Trp Gln 
                485                 490                 495     


Ser Glu Tyr Gly Gly Val Val Phe Gly Gly Trp Ala Arg Met Ala Gln 
            500                 505                 510         


Pro Ile Val Ala Phe Thr Val Val Glu Val Ala Lys Pro Asn Ile Gly 
        515                 520                 525             


Glu Asn Trp Pro Thr Arg Val Arg Ala Asp Val Thr Ile Asn Leu Asn 
    530                 535                 540                 


Val Arg Asp His Ile Lys Asp Glu Trp Glu Gly Leu Arg Lys His Asp 
545                 550                 555                 560 


Val Cys Phe Leu Ile Thr Val Arg Pro Thr Lys Pro Tyr Gly Thr Lys 
                565                 570                 575     


Phe Asp Arg Arg Arg Pro Phe Ile Glu Gln Val Gly Leu Val Tyr Val 
            580                 585                 590         


Arg Gly Cys Glu Ile Gln Gly Met Leu Asp Asp Lys Gly Arg Val Ile 
        595                 600                 605             


Glu Asp Gly Pro Glu Pro Arg Pro Asn Leu Arg Gly Glu Ser Arg Thr 
    610                 615                 620                 


Phe Arg Val Phe Leu Asp Pro Asn Gln Tyr Gln Gln Asp Met Thr Asn 
625                 630                 635                 640 


Thr Ile Gln Asn Gly Ala Glu Asp Val Tyr Glu Thr Phe Asn Ile Ile 
                645                 650                 655     


Met Arg Arg Lys Pro Lys Glu Asn Asn Phe Lys Ala Val Leu Glu Thr 
            660                 665                 670         


Ile Arg Asn Leu Met Asn Thr Asp Cys Val Val Pro Asp Trp Leu His 
        675                 680                 685             


Asp Ile Ile Leu Gly Tyr Gly Asp Pro Ser Ser Ala His Tyr Ser Lys 
    690                 695                 700                 


Met Pro Asn Gln Ile Ala Thr Leu Asp Phe Asn Asp Thr Phe Leu Ser 
705                 710                 715                 720 


Ile Glu His Leu Lys Ala Ser Phe Pro Gly His Asn Val Lys Val Thr 
                725                 730                 735     


Val Glu Asp Pro Ala Leu Gln Ile Pro Pro Phe Arg Ile Thr Phe Pro 
            740                 745                 750         


Val Arg Ser Gly Lys Gly Lys Lys Arg Lys Asp Ala Asp Val Glu Asp 
        755                 760                 765             


Glu Asp Thr Glu Glu Ala Lys Thr Leu Ile Val Glu Pro His Val Ile 
    770                 775                 780                 


Pro Asn Arg Gly Pro Tyr Pro Tyr Asn Gln Pro Lys Arg Asn Thr Ile 
785                 790                 795                 800 


Gln Phe Thr His Thr Gln Ile Glu Ala Ile Arg Ala Gly Met Gln Pro 
                805                 810                 815     


Gly Leu Thr Met Val Val Gly Pro Pro Gly Thr Gly Lys Thr Asp Val 
            820                 825                 830         


Ala Val Gln Ile Ile Ser Asn Ile Tyr His Asn Phe Pro Glu Gln Arg 
        835                 840                 845             


Thr Leu Ile Val Thr His Ser Asn Gln Ala Leu Asn Gln Leu Phe Glu 
    850                 855                 860                 


Lys Ile Met Ala Leu Asp Ile Asp Glu Arg His Leu Leu Arg Leu Gly 
865                 870                 875                 880 


His Gly Glu Glu Glu Leu Glu Thr Glu Lys Asp Phe Ser Arg Tyr Gly 
                885                 890                 895     


Arg Val Asn Tyr Val Leu Ala Arg Arg Ile Glu Leu Leu Glu Glu Val 
            900                 905                 910         


Lys Arg Leu Gln Lys Ser Leu Gly Val Pro Gly Asp Ala Ser Tyr Thr 
        915                 920                 925             


Cys Glu Thr Ala Gly Tyr Phe Phe Leu Tyr Gln Val Met Ser Arg Trp 
    930                 935                 940                 


Glu Glu Tyr Ile Ser Lys Val Lys Asn Lys Gly Ser Thr Leu Pro Asp 
945                 950                 955                 960 


Val Thr Glu Val Ser Thr Phe Phe Pro Phe His Glu Tyr Phe Ala Asn 
                965                 970                 975     


Ala Pro Gln Pro Ile Phe Lys Gly Arg Ser Tyr Glu Glu Asp Met Glu 
            980                 985                 990         


Ile Ala Glu Gly Cys Phe Arg His  Ile Lys Lys Ile Phe  Thr Gln Leu 
        995                 1000                 1005             


Glu Glu  Phe Arg Ala Ser Glu  Leu Leu Arg Ser Gly  Leu Asp Arg 
    1010                 1015                 1020             


Ser Lys  Tyr Leu Leu Val Lys  Glu Ala Lys Ile Ile  Ala Met Thr 
    1025                 1030                 1035             


Cys Thr  His Ala Ala Leu Lys  Arg His Asp Leu Val  Lys Leu Gly 
    1040                 1045                 1050             


Phe Lys  Tyr Asp Asn Ile Leu  Met Glu Glu Ala Ala  Gln Ile Leu 
    1055                 1060                 1065             


Glu Ile  Glu Thr Phe Ile Pro  Leu Leu Leu Gln Asn  Pro Gln Asp 
    1070                 1075                 1080             


Gly Phe  Ser Arg Leu Lys Arg  Trp Ile Met Ile Gly  Asp His His 
    1085                 1090                 1095             


Gln Leu  Pro Pro Val Ile Lys  Asn Met Ala Phe Gln  Lys Tyr Ser 
    1100                 1105                 1110             


Asn Met  Glu Gln Ser Leu Phe  Thr Arg Phe Val Arg  Val Gly Val 
    1115                 1120                 1125             


Pro Thr  Val Asp Leu Asp Ala  Gln Gly Arg Ala Arg  Ala Arg 
    1130                 1135                 1140         

<210>  3147
<211>  497
<212>  DNA
<213>  Homo sapiens

<400>  3147
cccagtgccg agtagggcct tgttaagaaa ccgcttatca ctaaatgatc tgtcttccag     60

ctctacaatg gcaagaatct gggacttact gtttatactg tttactttgc agttagcatg    120

taaatactgg gctccccaca tcaagaagaa atcacctttt gatataaagg ttattgaaga    180

tatatatgaa aaagagattg tcaaatcaag gtttgctatt agaaagataa tgctcttgga    240

atttagccag tatcttgaaa attatctctg gatgaattat tctcctgagg tatctagcaa    300

ggcctattta atgtcaatct gctgtatggt gaatgagaag tttagagaaa acgtgcctgc    360

atgggaggta actgatttaa agtacttcat agctttcata ctgacccaca taagccatta    420

caaagtggca gaacttttac tgatagtggt gcttttagag cagaacttta cccagtaata    480

aagcaaatat tgagaaa                                                   497


<210>  3148
<211>  136
<212>  PRT
<213>  Homo sapiens

<400>  3148


Met Ala Arg Ile Trp Asp Leu Leu Phe Ile Leu Phe Thr Leu Gln Leu 
1               5                   10                  15      


Ala Cys Lys Tyr Trp Ala Pro His Ile Lys Lys Lys Ser Pro Phe Asp 
            20                  25                  30          


Ile Lys Val Ile Glu Asp Ile Tyr Glu Lys Glu Ile Val Lys Ser Arg 
        35                  40                  45              


Phe Ala Ile Arg Lys Ile Met Leu Leu Glu Phe Ser Gln Tyr Leu Glu 
    50                  55                  60                  


Asn Tyr Leu Trp Met Asn Tyr Ser Pro Glu Val Ser Ser Lys Ala Tyr 
65                  70                  75                  80  


Leu Met Ser Ile Cys Cys Met Val Asn Glu Lys Phe Arg Glu Asn Val 
                85                  90                  95      


Pro Ala Trp Glu Val Thr Asp Leu Lys Tyr Phe Ile Ala Phe Ile Leu 
            100                 105                 110         


Thr His Ile Ser His Tyr Lys Val Ala Glu Leu Leu Leu Ile Val Val 
        115                 120                 125             


Leu Leu Glu Gln Asn Phe Thr Gln 
    130                 135     

<210>  3149
<211>  329
<212>  DNA
<213>  Homo sapiens

<400>  3149
gggactctga aggctgagga tatccggccc ggagcgtttg tgcggcgcgg agttaagcgc     60

cccggcagta acttaaggga agtggaccag ggttgccgct gcccagagcg gtcctttagt    120

ttccactgga gtggagggaa gagtgctgcc atggcagccc ctgcgcagcc caagaagatc    180

gtggccccta cggtgtccca aatcaatgcg gagttcgtga cccagttagc atgtaaatac    240

tgggctcccc acatcaagaa gaaatcacct tttgatataa aggtaagtat ttttggtttc    300

aacataattc ttgagaagtt acactcctt                                      329


<210>  3150
<211>  58
<212>  PRT
<213>  Homo sapiens

<400>  3150


Met Ala Ala Pro Ala Gln Pro Lys Lys Ile Val Ala Pro Thr Val Ser 
1               5                   10                  15      


Gln Ile Asn Ala Glu Phe Val Thr Gln Leu Ala Cys Lys Tyr Trp Ala 
            20                  25                  30          


Pro His Ile Lys Lys Lys Ser Pro Phe Asp Ile Lys Val Ser Ile Phe 
        35                  40                  45              


Gly Phe Asn Ile Ile Leu Glu Lys Leu His 
    50                  55              

<210>  3151
<211>  5305
<212>  DNA
<213>  Homo sapiens

<400>  3151
gcggacgtgc gcgcgctgcc ttcgcggcac ctgggcctga ggtgcgtgcc tcccgggccc     60

tcgccagctc cagatgcgtg aggaggactt cagaaacccg actgagaagt ggagcgaccc    120

ccagggaggg tcggacctgc ctcaataccg ccaagacatc tgtggaattt aagaacagta    180

tggagctcat cagagtatat cattgaagaa tatgatggct gaaaacaatt taaaaatgct    240

aaagattcaa cagtgtgtgg tagccaacaa actacctaga aacaggccat atgtttgcaa    300

tatttgtttt aagcactttg aaacaccatc aaaattagct aggcactatc tcattcatac    360

tggtcaaaag ccatttgaat gtgatgtgtg tcataaaacc tttagacaac tagttcatct    420

ggagaggcat caactaactc atagtctgcc ttttaaatgt agtatttgtc agcgtcactt    480

taaaaatctg aagacatttg tgaagcacca acaacttcac aatgaaacct atcagaataa    540

tgttaaacag gtcagaagat tgctggaggc caagcaagaa aagtcaatgt atggagtgta    600

taatactttt accacagagg aaagatgggc attacacccg tgctctaagt ctgatcccat    660

gtatagcatg aaaagaagaa agaatattca tgcatgtaca atctgtggca agatgtttcc    720

atcacagtca aaacttgata ggcatgtact tattcatact ggtcagaggc cttttaaatg    780

tgtcttgtgt actaaatctt ttcgacagtc aactcactta aaaatccacc aacttacaca    840

ttcagaagaa agaccttttc aatgttgttt ttgtcaaaaa ggatttaaga ttcaaagcaa    900

acttctgaag cataaacaaa tccatactag gaataaggct tttcgggctc ttttattaaa    960

gaagaggcgt acagaatctc gccccctgcc taataagtta aatgcaaatc agggtggttt   1020

tgaaaatggt gagattggtg aatctgagga gaataatcca cttgatgtcc actcaattta   1080

tattgtccct tttcaatgtc caaagtgtga aaagtgtttt gaatcagagc agattctcaa   1140

tgaacacagc tgttttgctg ctagaagtgg caaaattcca agcaggttca aaagaagcta   1200

caactataaa accattgtta aaaaaatctt ggccaagctt aagcgtgcta ggagtaaaaa   1260

attagataac tttcaatctg agaaaaaagt atttaaaaag agtttcttga gaaattgtga   1320

tcttatttct ggtgagcaga gctctgaaca aacccagaga acatttgtgg gttctcttgg   1380

caaacatgga acatataaaa caattggcaa tagaaagaag aaaacattga ctttgccatt   1440

ttcttggcaa aatatgggaa aaaatttgaa aggcatcctt acgacagaaa acatattaag   1500

cattgataat tcagtgaata agaaagactt gtcaatctgt ggttcatcag gtgaggaatt   1560

ctttaataac tgtgaggtac ttcagtgtgg tttttcagtt ccaagggaaa acatacgtac   1620

tagacataag atatgtcctt gtgacaaatg tgagaaggta tttccttcta tatccaaact   1680

aaaaagacac tatttaattc atactggaca gaggcccttt ggctgtaata tttgtgggaa   1740

atcttttaga cagtcagctc acttaaaaag acatgaacag actcataatg aaaagagtcc   1800

ttatgcatct ctttgccaag tagaatttgg aaacttcaac aatctttcta atcattcagg   1860

taataatgtt aactataatg cttcccaaca atgtcaggct cctggtgttc aaaaatacga   1920

ggtctcagag tcagatcaaa tgtcaggagt taaggcagag tcacaggatt ttattcctgg   1980

tagcaccggg caaccctgtc ttcctaatgt acttttggaa tcagagcaaa gcaatccttt   2040

ttgcagttat tcagagcatc aggagaaaaa tgatgtcttc ctgtaccgat gcagtgtttg   2100

tgctaaaagt ttccgatctc catctaaact ggaaagacac tacctaattc atgcagggca   2160

gaaaccattt gaatgctcag tttgtggcaa aacattcaga caggctcctc actggaagag   2220

acatcagctt actcacttta aagaacgacc acaagggaaa gtggttgcct tagattcggt   2280

tatgtaaatt gtcgcaacca ctaacaattg tggtctctgg tgatcttatt tttaaagcct   2340

gtattattta aaatgcattt ttattgaaag gcctgcatta aactgaatgg tttcacaggc   2400

atttgcttgt cctgcatagt aaggaggtag aatacataga aaattaatac aatgttttag   2460

aaacagccaa gttaatttta gaggcaagaa catgatttga tgctataaag taggcatttt   2520

aatattgtaa acatatactt tggctgtatt gaaaaatata aatccatgat ggctgtacaa   2580

ataatttagc ctcattcatt ttttaaagga attattcctt aagacatgcc atctcttttt   2640

agatatactc aaaagactga gaggcaaaac ttggctttta gctgcagcac atagccctgt   2700

tatatttgat ttattttaca tttcatatga aagcataatt ttgtccacat gtgactcaaa   2760

ttgcattggt aatttttttt ttttttttgt aagttaaaaa aactacagag acactaaagg   2820

tgaaaatgga tgagacaatt atagtattat tttcattggt cttttttttt gagatggagt   2880

ctcactcttt cgccaggcta gagtgcagtg gcgccatcta ggctcactgc aacctccgca   2940

tcccagattc cagcgattct cctgcctcag cctcctgagt agctgggatt acaggtgcct   3000

gccatcacgc ctggctaatt tttgtatttt tagtagagac gggggttcac caagttggcc   3060

aggatggtct cgatctcttg accttgtgac tcacccgcat cggcctccca aagtgctggg   3120

attacaggca tgagccaccg cacccgacgg tcttttcaaa gctatttatt tttaggacta   3180

tgtggtaatt tcaccttcag gtgataagga tttttttttt ctcccagcta gtgctatctt   3240

tctcaaaata atttaaaagt aggcgagagg ctaggatgta cctatattta ccatgtttac   3300

ttaccaggaa tattttctaa gtgccatagt ctttttcata atacgtatga gttttacctt   3360

ttcagaggaa taatttcaag tcatttattt gctcattaat gatagcagta gtcatagact   3420

taagactatt ctagagatct tcatctccat aagactttta catttatttt agtaaacttt   3480

tctttctatg cctctttaat ggagtggttc tgttatttaa gcctgttcta agtttgatca   3540

aatggcaatg actaggtcta gttttagttt ttatttttgc aggagtctat tgctaaagaa   3600

ttttattttg atgcttgtta aatttttatt ttaattaata aggtagtcat tcctgtagag   3660

ggataagatg cttgtagagt tgtgggtatc attccaaata gaactgttat gatttgggaa   3720

atattcttta ctacaaagga cttatttcat aattacaaat tttccttcat atttgccttt   3780

gtttataaaa tcttcaggaa tgacattctc tagcaataaa aggaatgaac cgttatgttt   3840

ctaagctgaa aagaggaaca ggtgggtaat tatcctgcca tacttaaata tagtggaaaa   3900

tcctctattg agaatgtgga taaatgaaca attgtaagtt ttgcatcata aactgagaac   3960

tttcttttga caggggggag gcgggaggga tagtaggtgg gggtgatctg cttgcttctt   4020

ttaccacagg tgatttttaa gtaacttggg tttaatttac agagatgaaa catgacagtc   4080

tgagtaaaat acccagtgat gtagaagtgt gcctgtttat tatgtagata cagacatcca   4140

gcaaaaacag gagaatcaca tgctttaaag aacactttct cttaggtttc cttgagatat   4200

gttcctccag tgcaagcaag ataatggttt acagaatttg ctttacacaa aacttgtcaa   4260

gaactcatct gttaaaagca aggaataact agtttatatt ttccaataat gttcaaggtt   4320

ttctccttaa tatgtttgaa attattgatt ttggcatttt tctaagcaat ttatgtaatt   4380

ttatttgaag aaaatgtttt gtataatgtt tttcccagcc taaacaggga gagtcctaac   4440

agtgttgtgc ttgtatgatt ctgagacttt atttgcgtaa gtgatactac tatactttat   4500

ttttgaccca tgccttttta agctgtttca tattgaaagg tggaatattg taaaaatttt   4560

gtcaaagatg tactgtagtg ctatttgaag tacctgtaac aaaacagttg gccctctgta   4620

tccatgtact ctgcatctgt ggattaaacc aattgcagat caaaaatatt agaaaaaata   4680

aaaataatac aaataaaaat acagtataac agttatttaa atagcattta cattgcatta   4740

ggtattagtc tagggataaa gtatacaggc ggatgtgcgt tggttatata caaatatgtc   4800

attttatgta agggacttga gtatacttgg atttttggta tctgtgggtt ggggggacgg   4860

tccaggaacc aataccccat ggataccaag ggacaactgt acttatttac ctttattgtc   4920

attgcaagct tcttatggaa actttatagg aatgaaaata tacatgttaa gaagattaaa   4980

cattagatag tagatggttt gttgcatgct agaactgtta gtattgttga atcaattact   5040

ttggtttcat gaaaaaataa acgataaata tctttaaaga gaactagaag aattttttgt   5100

ttgagtgatt ccaggctgta gtatgatcat ttactgaagt agtttgattg gctggctaac   5160

ttagaattat tgtttcttgt tttgtactgc aataggggtt ataattgtaa gataaaaatg   5220

tgtgtgtgtt taagggaagt aggtggtggt taaaattctt ggaaaatttt cagaatactt   5280

taaaaataaa gttccaagtt acaca                                         5305


<210>  3152
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  3152


Met Arg Glu Glu Asp Phe Arg Asn Pro Thr Glu Lys Trp Ser Asp Pro 
1               5                   10                  15      


Gln Gly Gly Ser Asp Leu Pro Gln Tyr Arg Gln Asp Ile Cys Gly Ile 
            20                  25                  30          

<210>  3153
<211>  5448
<212>  DNA
<213>  Homo sapiens

<400>  3153
gctcagcccg ttgccgcgcc ggccctgcgg acgtgcgcgc gctgccttcg cggcacctgg     60

gcctgaggtg cgtgcctccc gggccctcgc cagctccaga tgcgtgagga ggacttcaga    120

aacccgactg agaagtggag cgacccccag ggagggtcgg acctgcctca ataccgccaa    180

ggtctttcat ttcttgttcg cttactttcg tgaaatcctc acatcgtttt aatggtacta    240

gtcaagacaa gaaaatcaac aggctttcag ccttgaggca acattggata ttattgagac    300

atctgtggaa tttaagaaca gtatggagct catcagagta tatcattgaa gaatatgatg    360

gctgaaaaca atttaaaaat gctaaagatt caacagtgtg tggtagccaa caaactacct    420

agaaacaggc catatgtttg caatatttgt tttaagcact ttgaaacacc atcaaaatta    480

gctaggcact atctcattca tactggtcaa aagccatttg aatgtgatgt gtgtcataaa    540

acctttagac aactagttca tctggagagg catcaactaa ctcatagtct gccttttaaa    600

tgtagtattt gtcagcgtca ctttaaaaat ctgaagacat ttgtgaagca ccaacaactt    660

cacaatgaaa cctatcagaa taatgttaaa caggtcagaa gattgctgga ggccaagcaa    720

gaaaagtcaa tgtatggagt gtataatact tttaccacag aggaaagatg ggcattacac    780

ccgtgctcta agtctgatcc catgtatagc atgaaaagaa gaaagaatat tcatgcatgt    840

acaatctgtg gcaagatgtt tccatcacag tcaaaacttg ataggcatgt acttattcat    900

actggtcaga ggccttttaa atgtgtcttg tgtactaaat cttttcgaca gtcaactcac    960

ttaaaaatcc accaacttac acattcagaa gaaagacctt ttcaatgttg tttttgtcaa   1020

aaaggattta agattcaaag caaacttctg aagcataaac aaatccatac taggaataag   1080

gcttttcggg ctcttttatt aaagaagagg cgtacagaat ctcgccccct gcctaataag   1140

ttaaatgcaa atcagggtgg ttttgaaaat ggtgagattg gtgaatctga ggagaataat   1200

ccacttgatg tccactcaat ttatattgtc ccttttcaat gtccaaagtg tgaaaagtgt   1260

tttgaatcag agcagattct caatgaacac agctgttttg ctgctagaag tggcaaaatt   1320

ccaagcaggt tcaaaagaag ctacaactat aaaaccattg ttaaaaaaat cttggccaag   1380

cttaagcgtg ctaggagtaa aaaattagat aactttcaat ctgagaaaaa agtatttaaa   1440

aagagtttct tgagaaattg tgatcttatt tctggtgagc agagctctga acaaacccag   1500

agaacatttg tgggttctct tggcaaacat ggaacatata aaacaattgg caatagaaag   1560

aagaaaacat tgactttgcc attttcttgg caaaatatgg gaaaaaattt gaaaggcatc   1620

cttacgacag aaaacatatt aagcattgat aattcagtga ataagaaaga cttgtcaatc   1680

tgtggttcat caggtgagga attctttaat aactgtgagg tacttcagtg tggtttttca   1740

gttccaaggg aaaacatacg tactagacat aagatatgtc cttgtgacaa atgtgagaag   1800

gtatttcctt ctatatccaa actaaaaaga cactatttaa ttcatactgg acagaggccc   1860

tttggctgta atatttgtgg gaaatctttt agacagtcag ctcacttaaa aagacatgaa   1920

cagactcata atgaaaagag tccttatgca tctctttgcc aagtagaatt tggaaacttc   1980

aacaatcttt ctaatcattc aggtaataat gttaactata atgcttccca acaatgtcag   2040

gctcctggtg ttcaaaaata cgaggtctca gagtcagatc aaatgtcagg agttaaggca   2100

gagtcacagg attttattcc tggtagcacc gggcaaccct gtcttcctaa tgtacttttg   2160

gaatcagagc aaagcaatcc tttttgcagt tattcagagc atcaggagaa aaatgatgtc   2220

ttcctgtacc gatgcagtgt ttgtgctaaa agtttccgat ctccatctaa actggaaaga   2280

cactacctaa ttcatgcagg gcagaaacca tttgaatgct cagtttgtgg caaaacattc   2340

agacaggctc ctcactggaa gagacatcag cttactcact ttaaagaacg accacaaggg   2400

aaagtggttg ccttagattc ggttatgtaa attgtcgcaa ccactaacaa ttgtggtctc   2460

tggtgatctt atttttaaag cctgtattat ttaaaatgca tttttattga aaggcctgca   2520

ttaaactgaa tggtttcaca ggcatttgct tgtcctgcat agtaaggagg tagaatacat   2580

agaaaattaa tacaatgttt tagaaacagc caagttaatt ttagaggcaa gaacatgatt   2640

tgatgctata aagtaggcat tttaatattg taaacatata ctttggctgt attgaaaaat   2700

ataaatccat gatggctgta caaataattt agcctcattc attttttaaa ggaattattc   2760

cttaagacat gccatctctt tttagatata ctcaaaagac tgagaggcaa aacttggctt   2820

ttagctgcag cacatagccc tgttatattt gatttatttt acatttcata tgaaagcata   2880

attttgtcca catgtgactc aaattgcatt ggtaattttt tttttttttt tgtaagttaa   2940

aaaaactaca gagacactaa aggtgaaaat ggatgagaca attatagtat tattttcatt   3000

ggtctttttt tttgagatgg agtctcactc tttcgccagg ctagagtgca gtggcgccat   3060

ctaggctcac tgcaacctcc gcatcccaga ttccagcgat tctcctgcct cagcctcctg   3120

agtagctggg attacaggtg cctgccatca cgcctggcta atttttgtat ttttagtaga   3180

gacgggggtt caccaagttg gccaggatgg tctcgatctc ttgaccttgt gactcacccg   3240

catcggcctc ccaaagtgct gggattacag gcatgagcca ccgcacccga cggtcttttc   3300

aaagctattt atttttagga ctatgtggta atttcacctt caggtgataa ggattttttt   3360

tttctcccag ctagtgctat ctttctcaaa ataatttaaa agtaggcgag aggctaggat   3420

gtacctatat ttaccatgtt tacttaccag gaatattttc taagtgccat agtctttttc   3480

ataatacgta tgagttttac cttttcagag gaataatttc aagtcattta tttgctcatt   3540

aatgatagca gtagtcatag acttaagact attctagaga tcttcatctc cataagactt   3600

ttacatttat tttagtaaac ttttctttct atgcctcttt aatggagtgg ttctgttatt   3660

taagcctgtt ctaagtttga tcaaatggca atgactaggt ctagttttag tttttatttt   3720

tgcaggagtc tattgctaaa gaattttatt ttgatgcttg ttaaattttt attttaatta   3780

ataaggtagt cattcctgta gagggataag atgcttgtag agttgtgggt atcattccaa   3840

atagaactgt tatgatttgg gaaatattct ttactacaaa ggacttattt cataattaca   3900

aattttcctt catatttgcc tttgtttata aaatcttcag gaatgacatt ctctagcaat   3960

aaaaggaatg aaccgttatg tttctaagct gaaaagagga acaggtgggt aattatcctg   4020

ccatacttaa atatagtgga aaatcctcta ttgagaatgt ggataaatga acaattgtaa   4080

gttttgcatc ataaactgag aactttcttt tgacaggggg gaggcgggag ggatagtagg   4140

tgggggtgat ctgcttgctt cttttaccac aggtgatttt taagtaactt gggtttaatt   4200

tacagagatg aaacatgaca gtctgagtaa aatacccagt gatgtagaag tgtgcctgtt   4260

tattatgtag atacagacat ccagcaaaaa caggagaatc acatgcttta aagaacactt   4320

tctcttaggt ttccttgaga tatgttcctc cagtgcaagc aagataatgg tttacagaat   4380

ttgctttaca caaaacttgt caagaactca tctgttaaaa gcaaggaata actagtttat   4440

attttccaat aatgttcaag gttttctcct taatatgttt gaaattattg attttggcat   4500

ttttctaagc aatttatgta attttatttg aagaaaatgt tttgtataat gtttttccca   4560

gcctaaacag ggagagtcct aacagtgttg tgcttgtatg attctgagac tttatttgcg   4620

taagtgatac tactatactt tatttttgac ccatgccttt ttaagctgtt tcatattgaa   4680

aggtggaata ttgtaaaaat tttgtcaaag atgtactgta gtgctatttg aagtacctgt   4740

aacaaaacag ttggccctct gtatccatgt actctgcatc tgtggattaa accaattgca   4800

gatcaaaaat attagaaaaa ataaaaataa tacaaataaa aatacagtat aacagttatt   4860

taaatagcat ttacattgca ttaggtatta gtctagggat aaagtataca ggcggatgtg   4920

cgttggttat atacaaatat gtcattttat gtaagggact tgagtatact tggatttttg   4980

gtatctgtgg gttgggggga cggtccagga accaataccc catggatacc aagggacaac   5040

tgtacttatt tacctttatt gtcattgcaa gcttcttatg gaaactttat aggaatgaaa   5100

atatacatgt taagaagatt aaacattaga tagtagatgg tttgttgcat gctagaactg   5160

ttagtattgt tgaatcaatt actttggttt catgaaaaaa taaacgataa atatctttaa   5220

agagaactag aagaattttt tgtttgagtg attccaggct gtagtatgat catttactga   5280

agtagtttga ttggctggct aacttagaat tattgtttct tgttttgtac tgcaataggg   5340

gttataattg taagataaaa atgtgtgtgt gtttaaggga agtaggtggt ggttaaaatt   5400

cttggaaaat tttcagaata ctttaaaaat aaagttccaa gttacaca                5448


<210>  3154
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  3154


Met Arg Glu Glu Asp Phe Arg Asn Pro Thr Glu Lys Trp Ser Asp Pro 
1               5                   10                  15      


Gln Gly Gly Ser Asp Leu Pro Gln Tyr Arg Gln Gly Leu Ser Phe Leu 
            20                  25                  30          


Val Arg Leu Leu Ser 
        35          

<210>  3155
<211>  5081
<212>  DNA
<213>  Homo sapiens

<400>  3155
gcggacgtgc gcgcgctgcc ttcgcggcac ctgggcctga ggtgcgtgcc tcccgggccc     60

tcgccagctc cagatgcgtg aggaggactt cagaaacccg actgagaagt ggagcgaccc    120

ccagggaggg tcggacctgc ctcaataccg ccaagacatc tgtggaattt aagaacagta    180

tggagctcat cagagtatat cattgaagaa tatgatggct gaaaacaatt taaaaatgct    240

aaagattcaa cagtgtgtgg tagccaacaa actacctaga aacaggccat atgtttgcaa    300

tatttgtttt aagcactttg aaacaccatc aaaattagct aggcactatc tcattcatac    360

tggtcaaaag ccatttgaat gtgatgtgtg tcataaaacc tttagacaac tagttcatct    420

ggagaggcat caactaactc atagtctgcc ttttaaatgt agtatttgtc agcgtcactt    480

taaaaatctg aagacatttg tgaagcacca acaacttcac aatgaaacct atcagaataa    540

tgttaaacag gtcagaagat tgctggaggc caagcaagaa aagtcaatgt atggagtgta    600

taatactttt accacagagg aaagatgggc attacacccg tgctctaagt ctgatcccat    660

gtatagcatg aaaagaagaa agaatattca tgcatgtaca atctgtggca agatgtttcc    720

atcacagtca aaacttgata ggcatgtact tattcatact ggtcagaggc cttttaaatg    780

tgtcttgtgt actaaatctt ttcgacagtc aactcactta aaaatccacc aacttacaca    840

ttcagaagaa agaccttttc aatgttgttt ttgtcaaaaa ggatttaaga ttcaaagcaa    900

acttctgaag cataaacaaa tccatactag gaataaggct tttcgggctc ttttattaaa    960

gaagaggcgt acagaatctc gccccctgcc taataagtta aatgcaaatc agggtggttt   1020

tgaaaatggt gagattggtg aatctgagga gaataatcca cttgatgtcc actcaattta   1080

tattgtccct tttcaatgtc caaagtgtga aaagtgtttt gaatcagagc agattctcaa   1140

tgaacacagc tgttttgctg ctagaagtgg caaaattcca agcaggttca aaagaagcta   1200

caactataaa accattgtta aaaaaatctt ggccaagctt aagcgtgcta ggagtaaaaa   1260

attagataac tttcaatctg agaaaaaagt atttaaaaag agtttcttga gaaattgtga   1320

tcttatttct ggtgagcaga gctctgaaca aacccagaga acatttgtgg gttctcttgg   1380

caaacatgga acatataaaa caattggcaa tagaaagaag aaaacattga ctttgccatt   1440

ttcttggcaa aatatgggaa aaaatttgaa aggcatcctt acgacagaaa acatattaag   1500

cattgataat tcagtgaata agaaagactt gtcaatctgt ggttcatcag gtgaggaatt   1560

ctttaataac tgtgaggtac ttcagtgtgg tttttcagtt ccaagggaaa acatacgtac   1620

tagacataag atatgtcctt gtgacaaatg tgagaaggta tttccttcta tatccaaact   1680

aaaaagacac tatttaattc atactggaca gaggcccttt ggctgtaata tttgtgggaa   1740

atcttttaga cagtcagctc acttaaaaag acatgaacag actcataatg aaaagagtcc   1800

ttatgcatct ctttgccaag tagaatttgg aaacttcaac aatctttcta atcattcagg   1860

taataatgtt aactataatg cttcccaaca atgtcaggct cctggtgttc aaaaatacga   1920

ggtctcagag tcagatcaaa tgtcaggagt taaggcagag tcacaggatt ttattcctgg   1980

tagcaccggg caaccctgtc ttcctaatgt acttttggaa tcagagcaaa gcaatccttt   2040

ttgcagttat tcagagcatc aggagaaaaa tgatgtcttc ctgtaccgat gcagtgtttg   2100

tgctaaaagt ttccgatctc catctaaact ggaaagacac tacctaattc atgcagggca   2160

gaaaccattt gaatgctcag tttgtggcaa aacattcaga caggctcctc actggaagag   2220

acatcagctt actcacttta aagaacgacc acaagggaaa gtggttgcct tagattcggt   2280

tatgtaaatt gtcgcaacca ctaacaattg tggtctctgg tgatcttatt tttaaagcct   2340

gtattattta aaatgcattt ttattgaaag gcctgcatta aactgaatgg tttcacaggc   2400

atttgcttgt cctgcatagt aaggaggtag aatacataga aaattaatac aatgttttag   2460

aaacagccaa gttaatttta gaggcaagaa catgatttga tgctataaag taggcatttt   2520

aatattgtaa acatatactt tggctgtatt gaaaaatata aatccatgat ggctgtacaa   2580

ataatttagc ctcattcatt ttttaaagga attattcctt aagacatgcc atctcttttt   2640

agatatactc aaaagactga gaggcaaaac ttggctttta gctgcagcac atagccctgt   2700

tatatttgat ttattttaca tttcatatga aagcataatt ttgtccacat gtgactcaaa   2760

ttgcattggt aatttttttt ttttttttgt aagttaaaaa aactacagag acactaaagg   2820

tgaaaatgga tgagacaatt atagtattat tttcattggt cttttttttt gagatggagt   2880

ctcactcttt cgccaggcta gagtgcagtg gcgccatcta ggctcactgc aacctccgca   2940

tcccagattc cagcgattct cctgcctcag cctcctgagt agctgggatt acaggtgcct   3000

gccatcacgc ctggctaatt tttgtatttt tagtagagac gggggttcac caagttggcc   3060

aggatggtct cgatctcttg accttgtgac tcacccgcat cggcctccca aagtgctggg   3120

attacaggca tgagccaccg cacccgacgg tcttttcaaa gctatttatt tttaggacta   3180

tgtggtaatt tcaccttcag gtgataagga tttttttttt ctcccagcta gtgctatctt   3240

tctcaaaata atttaaaagt aggcgagagg ctaggatgta cctatattta ccatgtttac   3300

ttaccaggaa tattttctaa gtgccatagt ctttttcata atacgtatga gttttacctt   3360

ttcagaggaa taatttcaag tcatttattt gctcattaat gatagcagta gtcatagact   3420

taagactatt ctagagatct tcatctccat aagactttta catttatttt agtaaacttt   3480

tctttctatg cctctttaat ggagtggttc tgttatttaa gcctgttcta agtttgatca   3540

aatggcaatg actaggtcta gttttagttt ttatttttgc aggagtctat tgctaaagaa   3600

ttttattttg atgcttgtta aatttttatt ttaattaata aggtagtcat tcctgtagag   3660

ggataagatg cttgtagagt tgtgggtatc attccaaata gaactgttat gatttgggaa   3720

atattcttta ctacaaagga cttatttcat aattacaaat tttccttcat atttgccttt   3780

gtttataaaa tcttcaggaa tgacattctc tagcaataaa aggaatgaac cgttatgttt   3840

ctaagctgaa aagaggaaca ggtgggtaat tatcctgcca tacttaaata tagtggaaaa   3900

tcctctattg agaatgtgga taaatgaaca attgtaagtt ttgcatcata aactgagaac   3960

tttcttttga caggggggag gcgggaggga tagtaggtgg gggtgatctg cttgcttctt   4020

ttaccacagg tgatttttaa gtaacttggg tttaatttac agagatgaaa catgacagtc   4080

tgagtaaaat acccagtgat gtagaagtgt gcctgtttat tatgtagata cagacatcca   4140

gcaaaaacag gagaatcaca tgctttaaag aacactttct cttaggtttc cttgagatat   4200

gttcctccag tgcaagcaag ataatggttt acagaatttg ctttacacaa aacttgtcaa   4260

gaactcatct gttaaaagca aggaataact agtttatatt ttccaataat gttcaaggtt   4320

ttctccttaa tatgtttgaa attattgatt ttggcatttt tctaagcaat ttatgtaatt   4380

ttatttgaag aaaatgtttt gtataatgtt tttcccagcc taaacaggga gagtcctaac   4440

agtgttgtgc ttgtatgatt ctgagacttt atttgcgtaa gtgatactac tatactttat   4500

ttttgaccca tgccttttta agctgtttca tattgaaagg tggaatattg taaaaatttt   4560

gtcaaagatg tactgtagtg ctatttgaag tacctgtaac aaaacagttg gccctctgta   4620

tccatgtact ctgcatctgt ggattaaacc aattgcagat caaaaatatt agaaaaaata   4680

aaaataatac aaataaaaat acagtataac agttatttaa atagcattta cattgcatta   4740

ggtattagtc tagggataaa gtatacaggc ggatgtgcgt tggttatata caaatatgtc   4800

attttatgta agggacttga gtatacttgg atttttggta tctgtgggtt ggggggacgg   4860

tccaggaacc aataccccat ggataccaag ggacaactgt acttatttac ctttattgtc   4920

attgcaagct tcttatggaa actttatagg aatgaaaata tacatgttaa gaagattaaa   4980

cattagatag tagatggttt gttgcatgct agaactgtta gtattgttga atcaattact   5040

ttggtttcat gaaaaaataa acgataaata tctttaaaga g                       5081


<210>  3156
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  3156


Met Arg Glu Glu Asp Phe Arg Asn Pro Thr Glu Lys Trp Ser Asp Pro 
1               5                   10                  15      


Gln Gly Gly Ser Asp Leu Pro Gln Tyr Arg Gln Asp Ile Cys Gly Ile 
            20                  25                  30          

<210>  3157
<211>  5224
<212>  DNA
<213>  Homo sapiens

<400>  3157
gctcagcccg ttgccgcgcc ggccctgcgg acgtgcgcgc gctgccttcg cggcacctgg     60

gcctgaggtg cgtgcctccc gggccctcgc cagctccaga tgcgtgagga ggacttcaga    120

aacccgactg agaagtggag cgacccccag ggagggtcgg acctgcctca ataccgccaa    180

ggtctttcat ttcttgttcg cttactttcg tgaaatcctc acatcgtttt aatggtacta    240

gtcaagacaa gaaaatcaac aggctttcag ccttgaggca acattggata ttattgagac    300

atctgtggaa tttaagaaca gtatggagct catcagagta tatcattgaa gaatatgatg    360

gctgaaaaca atttaaaaat gctaaagatt caacagtgtg tggtagccaa caaactacct    420

agaaacaggc catatgtttg caatatttgt tttaagcact ttgaaacacc atcaaaatta    480

gctaggcact atctcattca tactggtcaa aagccatttg aatgtgatgt gtgtcataaa    540

acctttagac aactagttca tctggagagg catcaactaa ctcatagtct gccttttaaa    600

tgtagtattt gtcagcgtca ctttaaaaat ctgaagacat ttgtgaagca ccaacaactt    660

cacaatgaaa cctatcagaa taatgttaaa caggtcagaa gattgctgga ggccaagcaa    720

gaaaagtcaa tgtatggagt gtataatact tttaccacag aggaaagatg ggcattacac    780

ccgtgctcta agtctgatcc catgtatagc atgaaaagaa gaaagaatat tcatgcatgt    840

acaatctgtg gcaagatgtt tccatcacag tcaaaacttg ataggcatgt acttattcat    900

actggtcaga ggccttttaa atgtgtcttg tgtactaaat cttttcgaca gtcaactcac    960

ttaaaaatcc accaacttac acattcagaa gaaagacctt ttcaatgttg tttttgtcaa   1020

aaaggattta agattcaaag caaacttctg aagcataaac aaatccatac taggaataag   1080

gcttttcggg ctcttttatt aaagaagagg cgtacagaat ctcgccccct gcctaataag   1140

ttaaatgcaa atcagggtgg ttttgaaaat ggtgagattg gtgaatctga ggagaataat   1200

ccacttgatg tccactcaat ttatattgtc ccttttcaat gtccaaagtg tgaaaagtgt   1260

tttgaatcag agcagattct caatgaacac agctgttttg ctgctagaag tggcaaaatt   1320

ccaagcaggt tcaaaagaag ctacaactat aaaaccattg ttaaaaaaat cttggccaag   1380

cttaagcgtg ctaggagtaa aaaattagat aactttcaat ctgagaaaaa agtatttaaa   1440

aagagtttct tgagaaattg tgatcttatt tctggtgagc agagctctga acaaacccag   1500

agaacatttg tgggttctct tggcaaacat ggaacatata aaacaattgg caatagaaag   1560

aagaaaacat tgactttgcc attttcttgg caaaatatgg gaaaaaattt gaaaggcatc   1620

cttacgacag aaaacatatt aagcattgat aattcagtga ataagaaaga cttgtcaatc   1680

tgtggttcat caggtgagga attctttaat aactgtgagg tacttcagtg tggtttttca   1740

gttccaaggg aaaacatacg tactagacat aagatatgtc cttgtgacaa atgtgagaag   1800

gtatttcctt ctatatccaa actaaaaaga cactatttaa ttcatactgg acagaggccc   1860

tttggctgta atatttgtgg gaaatctttt agacagtcag ctcacttaaa aagacatgaa   1920

cagactcata atgaaaagag tccttatgca tctctttgcc aagtagaatt tggaaacttc   1980

aacaatcttt ctaatcattc aggtaataat gttaactata atgcttccca acaatgtcag   2040

gctcctggtg ttcaaaaata cgaggtctca gagtcagatc aaatgtcagg agttaaggca   2100

gagtcacagg attttattcc tggtagcacc gggcaaccct gtcttcctaa tgtacttttg   2160

gaatcagagc aaagcaatcc tttttgcagt tattcagagc atcaggagaa aaatgatgtc   2220

ttcctgtacc gatgcagtgt ttgtgctaaa agtttccgat ctccatctaa actggaaaga   2280

cactacctaa ttcatgcagg gcagaaacca tttgaatgct cagtttgtgg caaaacattc   2340

agacaggctc ctcactggaa gagacatcag cttactcact ttaaagaacg accacaaggg   2400

aaagtggttg ccttagattc ggttatgtaa attgtcgcaa ccactaacaa ttgtggtctc   2460

tggtgatctt atttttaaag cctgtattat ttaaaatgca tttttattga aaggcctgca   2520

ttaaactgaa tggtttcaca ggcatttgct tgtcctgcat agtaaggagg tagaatacat   2580

agaaaattaa tacaatgttt tagaaacagc caagttaatt ttagaggcaa gaacatgatt   2640

tgatgctata aagtaggcat tttaatattg taaacatata ctttggctgt attgaaaaat   2700

ataaatccat gatggctgta caaataattt agcctcattc attttttaaa ggaattattc   2760

cttaagacat gccatctctt tttagatata ctcaaaagac tgagaggcaa aacttggctt   2820

ttagctgcag cacatagccc tgttatattt gatttatttt acatttcata tgaaagcata   2880

attttgtcca catgtgactc aaattgcatt ggtaattttt tttttttttt tgtaagttaa   2940

aaaaactaca gagacactaa aggtgaaaat ggatgagaca attatagtat tattttcatt   3000

ggtctttttt tttgagatgg agtctcactc tttcgccagg ctagagtgca gtggcgccat   3060

ctaggctcac tgcaacctcc gcatcccaga ttccagcgat tctcctgcct cagcctcctg   3120

agtagctggg attacaggtg cctgccatca cgcctggcta atttttgtat ttttagtaga   3180

gacgggggtt caccaagttg gccaggatgg tctcgatctc ttgaccttgt gactcacccg   3240

catcggcctc ccaaagtgct gggattacag gcatgagcca ccgcacccga cggtcttttc   3300

aaagctattt atttttagga ctatgtggta atttcacctt caggtgataa ggattttttt   3360

tttctcccag ctagtgctat ctttctcaaa ataatttaaa agtaggcgag aggctaggat   3420

gtacctatat ttaccatgtt tacttaccag gaatattttc taagtgccat agtctttttc   3480

ataatacgta tgagttttac cttttcagag gaataatttc aagtcattta tttgctcatt   3540

aatgatagca gtagtcatag acttaagact attctagaga tcttcatctc cataagactt   3600

ttacatttat tttagtaaac ttttctttct atgcctcttt aatggagtgg ttctgttatt   3660

taagcctgtt ctaagtttga tcaaatggca atgactaggt ctagttttag tttttatttt   3720

tgcaggagtc tattgctaaa gaattttatt ttgatgcttg ttaaattttt attttaatta   3780

ataaggtagt cattcctgta gagggataag atgcttgtag agttgtgggt atcattccaa   3840

atagaactgt tatgatttgg gaaatattct ttactacaaa ggacttattt cataattaca   3900

aattttcctt catatttgcc tttgtttata aaatcttcag gaatgacatt ctctagcaat   3960

aaaaggaatg aaccgttatg tttctaagct gaaaagagga acaggtgggt aattatcctg   4020

ccatacttaa atatagtgga aaatcctcta ttgagaatgt ggataaatga acaattgtaa   4080

gttttgcatc ataaactgag aactttcttt tgacaggggg gaggcgggag ggatagtagg   4140

tgggggtgat ctgcttgctt cttttaccac aggtgatttt taagtaactt gggtttaatt   4200

tacagagatg aaacatgaca gtctgagtaa aatacccagt gatgtagaag tgtgcctgtt   4260

tattatgtag atacagacat ccagcaaaaa caggagaatc acatgcttta aagaacactt   4320

tctcttaggt ttccttgaga tatgttcctc cagtgcaagc aagataatgg tttacagaat   4380

ttgctttaca caaaacttgt caagaactca tctgttaaaa gcaaggaata actagtttat   4440

attttccaat aatgttcaag gttttctcct taatatgttt gaaattattg attttggcat   4500

ttttctaagc aatttatgta attttatttg aagaaaatgt tttgtataat gtttttccca   4560

gcctaaacag ggagagtcct aacagtgttg tgcttgtatg attctgagac tttatttgcg   4620

taagtgatac tactatactt tatttttgac ccatgccttt ttaagctgtt tcatattgaa   4680

aggtggaata ttgtaaaaat tttgtcaaag atgtactgta gtgctatttg aagtacctgt   4740

aacaaaacag ttggccctct gtatccatgt actctgcatc tgtggattaa accaattgca   4800

gatcaaaaat attagaaaaa ataaaaataa tacaaataaa aatacagtat aacagttatt   4860

taaatagcat ttacattgca ttaggtatta gtctagggat aaagtataca ggcggatgtg   4920

cgttggttat atacaaatat gtcattttat gtaagggact tgagtatact tggatttttg   4980

gtatctgtgg gttgggggga cggtccagga accaataccc catggatacc aagggacaac   5040

tgtacttatt tacctttatt gtcattgcaa gcttcttatg gaaactttat aggaatgaaa   5100

atatacatgt taagaagatt aaacattaga tagtagatgg tttgttgcat gctagaactg   5160

ttagtattgt tgaatcaatt actttggttt catgaaaaaa taaacgataa atatctttaa   5220

agag                                                                5224


<210>  3158
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  3158


Met Arg Glu Glu Asp Phe Arg Asn Pro Thr Glu Lys Trp Ser Asp Pro 
1               5                   10                  15      


Gln Gly Gly Ser Asp Leu Pro Gln Tyr Arg Gln Gly Leu Ser Phe Leu 
            20                  25                  30          


Val Arg Leu Leu Ser 
        35          

<210>  3159
<211>  3138
<212>  DNA
<213>  Homo sapiens

<400>  3159
acttagagcg ccgaacagct ctgggccaaa ggaccatgag agggccggag ccgggtcccc     60

aaccgacgat ggagggagac gtgctggaca cactggaggc gctggggtat aaaggaccat    120

tgttagaaga gcaagccctt acaaaggcgg cagagggtgg attatcttca cctgaatttt    180

cagagctctg tatttggtta ggctctcaaa taaaatcatt atgcaacttg gaagaaagta    240

tcacgtctgc tggaagagat gatctagaga gcttccagct tgagataagt ggctttttaa    300

aagaaatggc atgtccatat tctgtactca tatcaggaga tattaaagat cgtttaaaaa    360

agaaggagga ctgtttgaaa cttctattat ttttaagtac agaacttcaa gcttcacaga    420

tattacagaa caagaaacat aaaaattctc aattagataa aaatagtgaa gtttatcagg    480

aagttcaagc tatgtttgat acacttggta tacccaagtc aacaacttct gacattccgc    540

atatgctaaa ccaagtggaa tcaaaggtga aagatattct ctcaaaggtc cagaaaaatc    600

atgtgggaaa accactgctg aaaatggatt taaattcaga acaggcggaa caactggaaa    660

gaatcaatga tgctctttcc tgtgaatatg agtgccgccg acgaatgtta atgaaacgat    720

tagatgtgac tgtacagtcc tttggatggt ctgatagagc aaaggtaaaa acagatgata    780

tagcaagaat ttatcagcct aagcgttatg ctttgtcacc caagacaacg attacaatgg    840

cacatctact tgctgctcgt gaagatctat ccaagatcat taggacaagt agtggcacca    900

gccgggagaa gaccgcatgt gccattaata aggttggtgt ttctttcagt acagtggaaa    960

atgaattgat gatatcttac ttaatgtttt tacagatttt agtctatttt tctttcatgt   1020

cctggtaaat gtttagaaaa aagagtggca ggggggttca gtctaggctt agttatgtta   1080

tttttgtgta tgtgtgtatg ttcacttgaa tttgtgtatt cataaatcaa agtattttct   1140

gaattagagg aattatgaat tgtttttgtc aaagctttag caagaattat gttccatctt   1200

tctaaaaagt aatcattttt tgtcagtaag aatctttcgg aattgtttca agtactgaca   1260

gattcgttat atccttggtg taaagggaag aagagtttgt gctttagagt cagaccaatc   1320

tgggttccca tcctggctct gtcatttact tacagaaatg accctgagca agctactgaa   1380

cttctttgag cttctgtttc ctgatttgga gtatacatcc atttctctga cagtagtcta   1440

tttaaacaag ctcaaggagt ctgaattttt cactttacaa cagcaataac aataaagtaa   1500

tttagtatgt ttatgtcagc ttaactggca tgtcctcttc atttaggtag agcactccat   1560

ggcaaacttt attacaaaag agcaaaaaat cagaaataag ggatttggat aattttaaag   1620

catcgcttct cactcagtgt aacttgagat aaaatacctt ttcagaggga tggttgtttt   1680

taaagtcatt ttgctaacta ttgctaagtt aggcatcacc agtgtttgcc tctgtgcttc   1740

cactgtggct caatcctatg ttctgaaagt gttctctctt taaatatatt acctaacatc   1800

ttgcattggg tgataattta gtcttgctgg atcaagagtt ctatttctgt aagtaacatt   1860

ggccatctct tctgagttta taatttatgg tctcattatt tgagggtagt cttatgatca   1920

gttctggcat ctccatatgc ccaccaacat accatgtttg gtagagagac cagtgagaat   1980

aataaccaag aaaggctgtt ttttggattt ggtagttagg acatcattgc catctttaaa   2040

agaatgttgc atacttagaa ccttgtctca ctttgaggat attgcacttt ttatatttca   2100

tttgtgacat aaatcctaaa cttggttttg attggaggat caatggaagt gtataattaa   2160

ttggtcattt tggttgaggc agttgctttt ttactttctt tcctgaaagg cagtagcagg   2220

aagctattgg cttccccttg tctgtggtga gcagatgaca cccttcttat tgctatcttt   2280

cctctgctca tggcatataa agctgctact ttttatagaa ggttggatac ttaaactctt   2340

ccctagttta tttttgaaag gattataaag catagtaaag gaattatatt aactgtgttt   2400

tccttttaat aatatggtac tagtatcatc actgaaagta agtgagctta agtttcttaa   2460

aagaagcagt tcattgagaa tccttctctc tctttgcagt gatacctgga attatagttt   2520

ttatatcaat ctctgacctc attaaggtcc catgttatat gtacttcata catttttgaa   2580

atgaaatgtg cttaggaata taatctttta ttggataatc aattaccaaa tcaatggcaa   2640

tggaaagtcc agagttgtta ttgtataaat ggatattaag ttaatgaatg taaggtatgt   2700

cgttatatat ataaaaaatg ttttcctaaa agaacttctt agtgaaatgg gtactacatt   2760

tgttacagaa tttgctaaac aaatttaagt gagaaaaaaa ttaagccttt aagtttcaga   2820

aatactctct cagattgttt aaaaataata tattctaggc tgggtgtggt ggctcatgcc   2880

tgtaatccca gcactctggg aggccgaggc aggcggatca cgaggtcagg agatcaagac   2940

catcctggct aacacgttga aaccctgtct ccactaaaaa tacaaaaaat tagctgggcg   3000

tggtggcggg tgcctgtagt cccaactact cggggggctg aggcaggaga atggcgtgaa   3060

cccaggaggc agagcttgca gtgagctgag atcatgccac tgcactccag cctgggcaac   3120

agagcaagac tccatctc                                                 3138


<210>  3160
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  3160


Met Arg Gly Pro Glu Pro Gly Pro Gln Pro Thr Met Glu Gly Asp Val 
1               5                   10                  15      


Leu Asp Thr Leu Glu Ala Leu Gly Tyr Lys Gly Pro Leu Leu Glu Glu 
            20                  25                  30          


Gln Ala Leu Thr Lys Ala Ala Glu Gly Gly Leu Ser Ser Pro Glu Phe 
        35                  40                  45              


Ser Glu Leu Cys Ile Trp Leu Gly Ser Gln Ile Lys Ser Leu Cys Asn 
    50                  55                  60                  


Leu Glu Glu Ser Ile Thr Ser Ala Gly Arg Asp Asp Leu Glu Ser Phe 
65                  70                  75                  80  


Gln Leu Glu Ile Ser Gly Phe Leu Lys Glu Met Ala Cys Pro Tyr Ser 
                85                  90                  95      


Val Leu Ile Ser Gly Asp Ile Lys Asp Arg Leu Lys Lys Lys Glu Asp 
            100                 105                 110         


Cys Leu Lys Leu Leu Leu Phe Leu Ser Thr Glu Leu Gln Ala Ser Gln 
        115                 120                 125             


Ile Leu Gln Asn Lys Lys His Lys Asn Ser Gln Leu Asp Lys Asn Ser 
    130                 135                 140                 


Glu Val Tyr Gln Glu Val Gln Ala Met Phe Asp Thr Leu Gly Ile Pro 
145                 150                 155                 160 


Lys Ser Thr Thr Ser Asp Ile Pro His Met Leu Asn Gln Val Glu Ser 
                165                 170                 175     


Lys Val Lys Asp Ile Leu Ser Lys Val Gln Lys Asn His Val Gly Lys 
            180                 185                 190         


Pro Leu Leu Lys Met Asp Leu Asn Ser Glu Gln Ala Glu Gln Leu Glu 
        195                 200                 205             


Arg Ile Asn Asp Ala Leu Ser Cys Glu Tyr Glu Cys Arg Arg Arg Met 
    210                 215                 220                 


Leu Met Lys Arg Leu Asp Val Thr Val Gln Ser Phe Gly Trp Ser Asp 
225                 230                 235                 240 


Arg Ala Lys Val Lys Thr Asp Asp Ile Ala Arg Ile Tyr Gln Pro Lys 
                245                 250                 255     


Arg Tyr Ala Leu Ser Pro Lys Thr Thr Ile Thr Met Ala His Leu Leu 
            260                 265                 270         


Ala Ala Arg Glu Asp Leu Ser Lys Ile Ile Arg Thr Ser Ser Gly Thr 
        275                 280                 285             


Ser Arg Glu Lys Thr Ala Cys Ala Ile Asn Lys Val Gly Val Ser Phe 
    290                 295                 300                 


Ser Thr Val Glu Asn Glu Leu Met Ile Ser Tyr Leu Met Phe Leu Gln 
305                 310                 315                 320 


Ile Leu Val Tyr Phe Ser Phe Met Ser Trp 
                325                 330 

<210>  3161
<211>  5030
<212>  DNA
<213>  Homo sapiens

<400>  3161
acaaagtttg tgcctgcggt gcacctcggt cgggctcgcc gggctcgagg gctggcgggc     60

gccggggcta cgaggcccgg gggggagaga gccggcaggc ggcggcggtg gtggcggggg    120

cgatgcgccg cgcccggccg cgctaggtga gccggcaccg ggagcgcggg ccgcggccat    180

gggcaccctg ggcaaggcga gagaggctcc gcggaaacct tcccatggct gcagagctgc    240

ctctaaagca agactagagg caaagccagc caacagcccc ttcccctccc atcccagctt    300

ggcccacatc acccagttcc gaatgatggt gtctctggga catttagcca aaggagccag    360

cctggacgat ctcattgaca gctgcattca atcttttgat gcagatggaa acctgtgtcg    420

aagtaaccaa ctgttgcaag tcatgctgac catgcaccga attgtcatct cctctgcaga    480

actgctccaa aaagttatca ccccctacct ataaggatgc tttggcaaag aattcaccag    540

gactttgcct gaagatctgt tattttgtaa ggtattggat aacagaattc tgggtcatgt    600

ttaaaatgga cgccagcttg acagacacta tggaggagtt tcaggaactg gtgaaagcta    660

agggtgagga gttacattgc cgcctgattg acacaactca aatcaatgcc cgtgactggt    720

ccaggaaact tactcaaagg ataaaatcaa ataccagcaa gaaacggaaa gtctccctgc    780

tctttgacca tctggaacca gaagagctat ccgagcacct cacctacctt gagttcaagt    840

ctttccggag gatatcgttc tctgattatc agaattacct tgtaaatagc tgtgtgaagg    900

aaaaccccac catggagcga tctattgctc tgtgcaacgg catctcccag tgggtacaac    960

tgatggttct cagccgcccc acgccgcagc tccgagcaga agtcttcatc aagttcatcc   1020

aggtggctca gaagctccac caactacaga acttcaatac actgatggct gtgataggtg   1080

ggctgtgtca cagctcaatc tcgaggctca aggagacaag ttcgcatgtc ccacatgaaa   1140

tcaataaggt tctcggtgag atgactgagc tgctgtcctc ctccagaaac tacgacaatt   1200

accggcgagc ctatggagag tgcaccgact tcaagatccc cattctgggt gtgcatctca   1260

aggacctcat ctccctgtat gaagccatgc ctgactatct ggaggacggg aaagtgaacg   1320

tccataagct actggcccta tacaatcata tcagtgaatt ggtccagctg caagaggtgg   1380

ccccaccctt ggaggctaac aaggacttgg tacacttgct gacgttatcc ctggatcttt   1440

actacactga ggatgaaatc tatgagcttt cctatgcccg ggaaccaagg aaccacagag   1500

ctccaccact aacaccttca aagccaccag tagtagtgga ctgggcttct ggagtgtctc   1560

ccaaacctga tccaaaaacc attagcaaac acgtccagag gatggtggat tctgtcttca   1620

agaactatga tcacgaccag gatggataca tttctcagga agaatttgaa aagattgctg   1680

cgagttttcc attttccttc tgtgtgatgg acaaagacag ggaaggcctc atcagcaggg   1740

atgagatcac agcctacttc atgagagcca gctcaatcta ttccaagctg ggcctgggct   1800

ttcctcacaa cttccaagag accacctacc tgaagcccac tttttgtgac aactgtgctg   1860

gatttctctg gggagtgatc aaacaaggat atcgatgtaa agactgcggg atgaactgtc   1920

acaaacaatg caaagatctg gttgtgtttg agtgtaagaa gcgagccaag aacccagtag   1980

ctcccacaga gaacaacact tctgtggggc cagtgtccaa cctttgctca ttgggagcca   2040

aagatctgct ccatgcacct gaggaaggac cttttacatt ccctaatggg gaggctgtgg   2100

aacatggtga ggagagtaag gatcggacca tcatgctgat gggagtgtcc tcacagaaga   2160

tttctcttcg gctgaagagg gctgttgccc acaaggccac ccagactgaa tcacagcctt   2220

ggattggcag tgagggccct tcaggtccct ttgtgctgtc ttccccaagg aagacagccc   2280

aggatactct atatgtgctt cccagtccca cctctccatg tcctagccca gtcttggtca   2340

gaaagcgggc ttttgtcaag tgggagaata aagactccct cataaaatca aaggaggagc   2400

tccgtcacct cagactgcct acctaccaag aactggaaca ggaaataaat actctgaaag   2460

cagataatga tgccctaaag atccaactga aatatgcaca gaagaaaata gaatccctcc   2520

agcttgaaaa aagcaatcat gtcttagctc aaatggagca gggtgactgt tcttagccca   2580

gaaactaagt agcacaatct gtagatgagt atagtgatct catttcctaa actgtaatgc   2640

acagacctga ggaactttac actgaccagc tttaaaacag tactttaaaa ggaaaagcct   2700

gttactgttt atttacctaa aagattccta atgtgcagca ctgttttctc tttcagttag   2760

ttgactcaaa gggggaaaac taaagaatgc aaaacttttg ctattcatac cactgatgtt   2820

catcaaaagt atgcgatcta aaacatgact atcatttcct gacaatgggg catctcggtg   2880

gcctgcctgg ctgattcttc cttaaaacta aaatctctgg aaaatggatt tgcttcttac   2940

cctgtgtttt ctgcaaactg acttactttg ttccagccaa agcttgctaa taatagaaaa   3000

ctacccatat tccaaaagta gatttcctct gtatcccagc atactttgtg aacctggctc   3060

cttcttcact acctcagatc taatcaatta gtccatgtac cctccttcct cactacagtc   3120

ataacacatg agcatatcta cctagaagcc aatttctact gatgtagcca caacttttta   3180

gaggcctatt aaacatgacg ttatccaatt gcaggtcaac ttatagttgt agccttacaa   3240

cttacaggca tcagaaaata agtaatcaaa ttaggtacct ggaaacatag ctattaccat   3300

ctcatattac tgtctaatta aaataaacat aacgcaaaca tgtttgtcct tatatattct   3360

acagtggata gaattaggaa ttgatggctt aaaaaaaaaa gtctatgaag agtctgttta   3420

actcttcatg ttccatcttt ctcttctgaa gtaaactatt ttgaaagttc tctttttgaa   3480

atgaatttgt gcttaactgt cttcactatt aatactattt agaaataagc taattggatc   3540

agtggcttaa ataatagctg actgtgtgta catatgtata taatatgtat atacaatatc   3600

aggcatgcat gtggcttgga attttgtttc ctccataaaa tgtggaagtg aattaaacaa   3660

gttttagtca tttatacaaa gtcacaaata taaagttcag tttgtcacaa gattaaattg   3720

ctcacaaggt aaaattgtat tgtttggcaa aatcacaagt aacaatcctg tgagttttct   3780

attatgaagg ttaataataa atgggctcat ttagttgcct gggcacctat tcacaaattc   3840

atttgtcagc ctctttttag ttctcttaaa aaaaaaaaaa tcatatgatc attttccttt   3900

ttgggggtac ttagcttcca tgcctataaa gtctggtacc agactgactt gaaattcata   3960

aacaagttgt ccaattgcca agaatatgtt aacaattaaa agttccaaac taaagccaat   4020

agcaccaagt cttcataaga atacaaagta tacatacagt attgcttacc tggaggattc   4080

agatcattta ggaattctct ttgatgaaag atcagttccc atttgagttc ctccttgcac   4140

tgagttttag tgatatagaa ctagcttgta gttagtgttt cattacatta taaagaatag   4200

ttttacacac gtatttaccg ttttccaaat ttaaactcag aaatacccaa agcaggcctg   4260

cttaagccca ctacctggca tataaactta tagtaacact ttgttacttt ctttttaata   4320

ggacaagcat gagttaggac aaactctaaa aattcatatt cttcactatt cttgttttcc   4380

tttgattgat atagaccaaa gatggtgtac tctaattttt taaaacagta atggaacaca   4440

atttttttca ttcttcctcc tctccattcg aagtaaagat ccccagttag tttttatata   4500

aataatctat agggattcaa aaggtgtcac agtccactta attagtcaaa ttagcaatgg   4560

ctaaacagta tcaagtactg cagaatttat cactgaaatg gataagagga aatagtttag   4620

tcacaggttt ttacagtcca gcaagggcca aagaggtata gtatacaagt taatagtatt   4680

tgtgttgagc aacatggggc tagtgggatc acagaaatct ggaaaaaaaa aaaaaaggct   4740

ttggcttatc aagcctagtg taaatttctg catctcacac gactttagtt tggccaggta   4800

tttatctgcc aaaacaagga caaatcttgt tgtattaaca gcagggtcac ttctcatttt   4860

ctttgctgac ttaccttttt actgaccgtt gtgaatttct gtctcaaaat gtataatata   4920

gaaatgcaag aaaaaaacaa atgtacagat tgtaaagttt tttgatacct aatgtaagtt   4980

ttctttgtgt aatatttata tgataaaaga cattaggatc cctacaacac              5030


<210>  3162
<211>  659
<212>  PRT
<213>  Homo sapiens

<400>  3162


Met Phe Lys Met Asp Ala Ser Leu Thr Asp Thr Met Glu Glu Phe Gln 
1               5                   10                  15      


Glu Leu Val Lys Ala Lys Gly Glu Glu Leu His Cys Arg Leu Ile Asp 
            20                  25                  30          


Thr Thr Gln Ile Asn Ala Arg Asp Trp Ser Arg Lys Leu Thr Gln Arg 
        35                  40                  45              


Ile Lys Ser Asn Thr Ser Lys Lys Arg Lys Val Ser Leu Leu Phe Asp 
    50                  55                  60                  


His Leu Glu Pro Glu Glu Leu Ser Glu His Leu Thr Tyr Leu Glu Phe 
65                  70                  75                  80  


Lys Ser Phe Arg Arg Ile Ser Phe Ser Asp Tyr Gln Asn Tyr Leu Val 
                85                  90                  95      


Asn Ser Cys Val Lys Glu Asn Pro Thr Met Glu Arg Ser Ile Ala Leu 
            100                 105                 110         


Cys Asn Gly Ile Ser Gln Trp Val Gln Leu Met Val Leu Ser Arg Pro 
        115                 120                 125             


Thr Pro Gln Leu Arg Ala Glu Val Phe Ile Lys Phe Ile Gln Val Ala 
    130                 135                 140                 


Gln Lys Leu His Gln Leu Gln Asn Phe Asn Thr Leu Met Ala Val Ile 
145                 150                 155                 160 


Gly Gly Leu Cys His Ser Ser Ile Ser Arg Leu Lys Glu Thr Ser Ser 
                165                 170                 175     


His Val Pro His Glu Ile Asn Lys Val Leu Gly Glu Met Thr Glu Leu 
            180                 185                 190         


Leu Ser Ser Ser Arg Asn Tyr Asp Asn Tyr Arg Arg Ala Tyr Gly Glu 
        195                 200                 205             


Cys Thr Asp Phe Lys Ile Pro Ile Leu Gly Val His Leu Lys Asp Leu 
    210                 215                 220                 


Ile Ser Leu Tyr Glu Ala Met Pro Asp Tyr Leu Glu Asp Gly Lys Val 
225                 230                 235                 240 


Asn Val His Lys Leu Leu Ala Leu Tyr Asn His Ile Ser Glu Leu Val 
                245                 250                 255     


Gln Leu Gln Glu Val Ala Pro Pro Leu Glu Ala Asn Lys Asp Leu Val 
            260                 265                 270         


His Leu Leu Thr Leu Ser Leu Asp Leu Tyr Tyr Thr Glu Asp Glu Ile 
        275                 280                 285             


Tyr Glu Leu Ser Tyr Ala Arg Glu Pro Arg Asn His Arg Ala Pro Pro 
    290                 295                 300                 


Leu Thr Pro Ser Lys Pro Pro Val Val Val Asp Trp Ala Ser Gly Val 
305                 310                 315                 320 


Ser Pro Lys Pro Asp Pro Lys Thr Ile Ser Lys His Val Gln Arg Met 
                325                 330                 335     


Val Asp Ser Val Phe Lys Asn Tyr Asp His Asp Gln Asp Gly Tyr Ile 
            340                 345                 350         


Ser Gln Glu Glu Phe Glu Lys Ile Ala Ala Ser Phe Pro Phe Ser Phe 
        355                 360                 365             


Cys Val Met Asp Lys Asp Arg Glu Gly Leu Ile Ser Arg Asp Glu Ile 
    370                 375                 380                 


Thr Ala Tyr Phe Met Arg Ala Ser Ser Ile Tyr Ser Lys Leu Gly Leu 
385                 390                 395                 400 


Gly Phe Pro His Asn Phe Gln Glu Thr Thr Tyr Leu Lys Pro Thr Phe 
                405                 410                 415     


Cys Asp Asn Cys Ala Gly Phe Leu Trp Gly Val Ile Lys Gln Gly Tyr 
            420                 425                 430         


Arg Cys Lys Asp Cys Gly Met Asn Cys His Lys Gln Cys Lys Asp Leu 
        435                 440                 445             


Val Val Phe Glu Cys Lys Lys Arg Ala Lys Asn Pro Val Ala Pro Thr 
    450                 455                 460                 


Glu Asn Asn Thr Ser Val Gly Pro Val Ser Asn Leu Cys Ser Leu Gly 
465                 470                 475                 480 


Ala Lys Asp Leu Leu His Ala Pro Glu Glu Gly Pro Phe Thr Phe Pro 
                485                 490                 495     


Asn Gly Glu Ala Val Glu His Gly Glu Glu Ser Lys Asp Arg Thr Ile 
            500                 505                 510         


Met Leu Met Gly Val Ser Ser Gln Lys Ile Ser Leu Arg Leu Lys Arg 
        515                 520                 525             


Ala Val Ala His Lys Ala Thr Gln Thr Glu Ser Gln Pro Trp Ile Gly 
    530                 535                 540                 


Ser Glu Gly Pro Ser Gly Pro Phe Val Leu Ser Ser Pro Arg Lys Thr 
545                 550                 555                 560 


Ala Gln Asp Thr Leu Tyr Val Leu Pro Ser Pro Thr Ser Pro Cys Pro 
                565                 570                 575     


Ser Pro Val Leu Val Arg Lys Arg Ala Phe Val Lys Trp Glu Asn Lys 
            580                 585                 590         


Asp Ser Leu Ile Lys Ser Lys Glu Glu Leu Arg His Leu Arg Leu Pro 
        595                 600                 605             


Thr Tyr Gln Glu Leu Glu Gln Glu Ile Asn Thr Leu Lys Ala Asp Asn 
    610                 615                 620                 


Asp Ala Leu Lys Ile Gln Leu Lys Tyr Ala Gln Lys Lys Ile Glu Ser 
625                 630                 635                 640 


Leu Gln Leu Glu Lys Ser Asn His Val Leu Ala Gln Met Glu Gln Gly 
                645                 650                 655     


Asp Cys Ser 
            

<210>  3163
<211>  5289
<212>  DNA
<213>  Homo sapiens

<400>  3163
acaaagtttg tgcctgcggt gcacctcggt cgggctcgcc gggctcgagg gctggcgggc     60

gccggggcta cgaggcccgg gggggagaga gccggcaggc ggcggcggtg gtggcggggg    120

cgatgcgccg cgcccggccg cgctaggtga gccggcaccg ggagcgcggg ccgcggccat    180

gggcaccctg ggcaaggcga gagaggctcc gcggaaacct tcccatggct gcagagctgc    240

ctctaaagca agactagagg caaagccagc caacagcccc ttcccctccc atcccagctt    300

ggcccacatc acccagttcc gaatgatggt gtctctggga catttagcca aaggagccag    360

cctggacgat ctcattgaca gctgcattca atcttttgat gcagatggaa acctgtgtcg    420

aagtaaccaa ctgttgcaag tcatgctgac catgcaccga attgtcatct cctctgcaga    480

actgctccaa aaagttatca ccccctacct ataaggatgc tttggcaaag aattcaccag    540

gactttgcct gaagatctgt tattttgtaa ggtattggat aacagaattc tgggtcatgt    600

ttaaaatgga cgccagcttg acagacacta tggaggagtt tcaggaactg gtgaaagcta    660

agggtgagga gttacattgc cgcctgattg acacaactca aatcaatgcc cgtgactggt    720

ccaggaaact tactcaaagg ataaaatcaa ataccagcaa gaaacggaaa gtctccctgc    780

tctttgacca tctggaacca gaagagctat ccgagcacct cacctacctt gagttcaagt    840

ctttccggag gatatcgttc tctgattatc agaattacct tgtaaatagc tgtgtgaagg    900

aaaaccccac catggagcga tctattgctc tgtgcaacgg catctcccag tgggtacaac    960

tgatggttct cagccgcccc acgccgcagc tccgagcaga agtcttcatc aagttcatcc   1020

aggtggctca gaagctccac caactacaga acttcaatac actgatggct gtgataggtg   1080

ggctgtgtca cagctcaatc tcgaggctca aggagacaag ttcgcatgtc ccacatgaaa   1140

tcaataaggt tctcggtgag atgactgagc tgctgtcctc ctccagaaac tacgacaatt   1200

accggcgagc ctatggagag tgcaccgact tcaagatccc cattctgggt gtgcatctca   1260

aggacctcat ctccctgtat gaagccatgc ctgactatct ggaggacggg aaagtgaacg   1320

tccataagct actggcccta tacaatcata tcagtgaatt ggtccagctg caagaggtgg   1380

ccccaccctt ggaggctaac aaggacttgg tacacttgct gacgttatcc ctggatcttt   1440

actacactga ggatgaaatc tatgagcttt cctatgcccg ggaaccaagg aaccacagag   1500

ctccatctgt cttcaagaac tatgatcacg accaggatgg atacatttct caggaagaat   1560

ttgaaaagat tgctgcgagt tttccatttt ccttctgtgt gatggacaaa gacagggaag   1620

gcctcatcag cagggatgag atcacagcct acttcatgag agccagctca atctattcca   1680

agctgggcct gggctttcct cacaacttcc aagagaccac ctacctgaag cccacttttt   1740

gtgacaactg tgctggattt ctctggggag tgatcaaaca aggatatcga tgtaaagact   1800

gcgggatgaa ctgtcacaaa caatgcaaag atctggttgt gtttgagtgt aagaagcgag   1860

ccaagaaccc agtagctccc acagagaaca acacttctgt ggggccagtg tccaaccttt   1920

gctcattggg agccaaagat ctgctccatg cacctgagga aggacctttt acattcccta   1980

atggggaggc tgtggaacat ggtgaggaga gtaaggatcg gaccatcatg ctgatgggag   2040

tgtcctcaca gaagatttct cttcggctga agagggctgt tgcccacaag gccacccaga   2100

ctgaatcaca gccttggatt ggcagtgagg gcccttcagg tccctttgtg ctgtcttccc   2160

caaggaagac agcccaggat actctatatg tgcttcccag tcccacctct ccatgtccta   2220

gcccagtctt ggtcagaaag cgggcttttg tcaagtggga gaataaagac tccctcataa   2280

aatcaaagga ggagctccgt cacctcagac tgcctaccta ccaagaactg gaacagaatt   2340

ctcagtcatg ctttcatggc tcagacctga ccagagactg tttctgccaa gttgagatct   2400

cccgcgagaa aacatccaaa agttttgtca ttatctacct attgctcgga aatggtttat   2460

tctgcctgct aaccactcac aaactttgat atgataacaa agactaactg ctgcttacaa   2520

atgctcgttt gatatttaac ttgctatttt ctattcaggg caaaataact atcttgaaaa   2580

tggttgttaa ttctcagcca cagtgaatag gaaatgccaa tcaaaagtag ctctcaattt   2640

gtaattcatt tgctattcat tgctgcttta ttaacatacc tcattctcct ttccctttag   2700

gaaataaata ctctgaaagc agataatgat gccctaaaga tccaactgaa atatgcacag   2760

aagaaaatag aatccctcca gcttgaaaaa agcaatcatg tcttagctca aatggagcag   2820

ggtgactgtt cttagcccag aaactaagta gcacaatctg tagatgagta tagtgatctc   2880

atttcctaaa ctgtaatgca cagacctgag gaactttaca ctgaccagct ttaaaacagt   2940

actttaaaag gaaaagcctg ttactgttta tttacctaaa agattcctaa tgtgcagcac   3000

tgttttctct ttcagttagt tgactcaaag ggggaaaact aaagaatgca aaacttttgc   3060

tattcatacc actgatgttc atcaaaagta tgcgatctaa aacatgacta tcatttcctg   3120

acaatggggc atctcggtgg cctgcctggc tgattcttcc ttaaaactaa aatctctgga   3180

aaatggattt gcttcttacc ctgtgttttc tgcaaactga cttactttgt tccagccaaa   3240

gcttgctaat aatagaaaac tacccatatt ccaaaagtag atttcctctg tatcccagca   3300

tactttgtga acctggctcc ttcttcacta cctcagatct aatcaattag tccatgtacc   3360

ctccttcctc actacagtca taacacatga gcatatctac ctagaagcca atttctactg   3420

atgtagccac aactttttag aggcctatta aacatgacgt tatccaattg caggtcaact   3480

tatagttgta gccttacaac ttacaggcat cagaaaataa gtaatcaaat taggtacctg   3540

gaaacatagc tattaccatc tcatattact gtctaattaa aataaacata acgcaaacat   3600

gtttgtcctt atatattcta cagtggatag aattaggaat tgatggctta aaaaaaaaag   3660

tctatgaaga gtctgtttaa ctcttcatgt tccatctttc tcttctgaag taaactattt   3720

tgaaagttct ctttttgaaa tgaatttgtg cttaactgtc ttcactatta atactattta   3780

gaaataagct aattggatca gtggcttaaa taatagctga ctgtgtgtac atatgtatat   3840

aatatgtata tacaatatca ggcatgcatg tggcttggaa ttttgtttcc tccataaaat   3900

gtggaagtga attaaacaag ttttagtcat ttatacaaag tcacaaatat aaagttcagt   3960

ttgtcacaag attaaattgc tcacaaggta aaattgtatt gtttggcaaa atcacaagta   4020

acaatcctgt gagttttcta ttatgaaggt taataataaa tgggctcatt tagttgcctg   4080

ggcacctatt cacaaattca tttgtcagcc tctttttagt tctcttaaaa aaaaaaaaat   4140

catatgatca ttttcctttt tgggggtact tagcttccat gcctataaag tctggtacca   4200

gactgacttg aaattcataa acaagttgtc caattgccaa gaatatgtta acaattaaaa   4260

gttccaaact aaagccaata gcaccaagtc ttcataagaa tacaaagtat acatacagta   4320

ttgcttacct ggaggattca gatcatttag gaattctctt tgatgaaaga tcagttccca   4380

tttgagttcc tccttgcact gagttttagt gatatagaac tagcttgtag ttagtgtttc   4440

attacattat aaagaatagt tttacacacg tatttaccgt tttccaaatt taaactcaga   4500

aatacccaaa gcaggcctgc ttaagcccac tacctggcat ataaacttat agtaacactt   4560

tgttactttc tttttaatag gacaagcatg agttaggaca aactctaaaa attcatattc   4620

ttcactattc ttgttttcct ttgattgata tagaccaaag atggtgtact ctaatttttt   4680

aaaacagtaa tggaacacaa tttttttcat tcttcctcct ctccattcga agtaaagatc   4740

cccagttagt ttttatataa ataatctata gggattcaaa aggtgtcaca gtccacttaa   4800

ttagtcaaat tagcaatggc taaacagtat caagtactgc agaatttatc actgaaatgg   4860

ataagaggaa atagtttagt cacaggtttt tacagtccag caagggccaa agaggtatag   4920

tatacaagtt aatagtattt gtgttgagca acatggggct agtgggatca cagaaatctg   4980

gaaaaaaaaa aaaaaggctt tggcttatca agcctagtgt aaatttctgc atctcacacg   5040

actttagttt ggccaggtat ttatctgcca aaacaaggac aaatcttgtt gtattaacag   5100

cagggtcact tctcattttc tttgctgact taccttttta ctgaccgttg tgaatttctg   5160

tctcaaaatg tataatatag aaatgcaaga aaaaaacaaa tgtacagatt gtaaagtttt   5220

ttgataccta atgtaagttt tctttgtgta atatttatat gataaaagac attaggatcc   5280

ctacaacac                                                           5289


<210>  3164
<211>  630
<212>  PRT
<213>  Homo sapiens

<400>  3164


Met Phe Lys Met Asp Ala Ser Leu Thr Asp Thr Met Glu Glu Phe Gln 
1               5                   10                  15      


Glu Leu Val Lys Ala Lys Gly Glu Glu Leu His Cys Arg Leu Ile Asp 
            20                  25                  30          


Thr Thr Gln Ile Asn Ala Arg Asp Trp Ser Arg Lys Leu Thr Gln Arg 
        35                  40                  45              


Ile Lys Ser Asn Thr Ser Lys Lys Arg Lys Val Ser Leu Leu Phe Asp 
    50                  55                  60                  


His Leu Glu Pro Glu Glu Leu Ser Glu His Leu Thr Tyr Leu Glu Phe 
65                  70                  75                  80  


Lys Ser Phe Arg Arg Ile Ser Phe Ser Asp Tyr Gln Asn Tyr Leu Val 
                85                  90                  95      


Asn Ser Cys Val Lys Glu Asn Pro Thr Met Glu Arg Ser Ile Ala Leu 
            100                 105                 110         


Cys Asn Gly Ile Ser Gln Trp Val Gln Leu Met Val Leu Ser Arg Pro 
        115                 120                 125             


Thr Pro Gln Leu Arg Ala Glu Val Phe Ile Lys Phe Ile Gln Val Ala 
    130                 135                 140                 


Gln Lys Leu His Gln Leu Gln Asn Phe Asn Thr Leu Met Ala Val Ile 
145                 150                 155                 160 


Gly Gly Leu Cys His Ser Ser Ile Ser Arg Leu Lys Glu Thr Ser Ser 
                165                 170                 175     


His Val Pro His Glu Ile Asn Lys Val Leu Gly Glu Met Thr Glu Leu 
            180                 185                 190         


Leu Ser Ser Ser Arg Asn Tyr Asp Asn Tyr Arg Arg Ala Tyr Gly Glu 
        195                 200                 205             


Cys Thr Asp Phe Lys Ile Pro Ile Leu Gly Val His Leu Lys Asp Leu 
    210                 215                 220                 


Ile Ser Leu Tyr Glu Ala Met Pro Asp Tyr Leu Glu Asp Gly Lys Val 
225                 230                 235                 240 


Asn Val His Lys Leu Leu Ala Leu Tyr Asn His Ile Ser Glu Leu Val 
                245                 250                 255     


Gln Leu Gln Glu Val Ala Pro Pro Leu Glu Ala Asn Lys Asp Leu Val 
            260                 265                 270         


His Leu Leu Thr Leu Ser Leu Asp Leu Tyr Tyr Thr Glu Asp Glu Ile 
        275                 280                 285             


Tyr Glu Leu Ser Tyr Ala Arg Glu Pro Arg Asn His Arg Ala Pro Ser 
    290                 295                 300                 


Val Phe Lys Asn Tyr Asp His Asp Gln Asp Gly Tyr Ile Ser Gln Glu 
305                 310                 315                 320 


Glu Phe Glu Lys Ile Ala Ala Ser Phe Pro Phe Ser Phe Cys Val Met 
                325                 330                 335     


Asp Lys Asp Arg Glu Gly Leu Ile Ser Arg Asp Glu Ile Thr Ala Tyr 
            340                 345                 350         


Phe Met Arg Ala Ser Ser Ile Tyr Ser Lys Leu Gly Leu Gly Phe Pro 
        355                 360                 365             


His Asn Phe Gln Glu Thr Thr Tyr Leu Lys Pro Thr Phe Cys Asp Asn 
    370                 375                 380                 


Cys Ala Gly Phe Leu Trp Gly Val Ile Lys Gln Gly Tyr Arg Cys Lys 
385                 390                 395                 400 


Asp Cys Gly Met Asn Cys His Lys Gln Cys Lys Asp Leu Val Val Phe 
                405                 410                 415     


Glu Cys Lys Lys Arg Ala Lys Asn Pro Val Ala Pro Thr Glu Asn Asn 
            420                 425                 430         


Thr Ser Val Gly Pro Val Ser Asn Leu Cys Ser Leu Gly Ala Lys Asp 
        435                 440                 445             


Leu Leu His Ala Pro Glu Glu Gly Pro Phe Thr Phe Pro Asn Gly Glu 
    450                 455                 460                 


Ala Val Glu His Gly Glu Glu Ser Lys Asp Arg Thr Ile Met Leu Met 
465                 470                 475                 480 


Gly Val Ser Ser Gln Lys Ile Ser Leu Arg Leu Lys Arg Ala Val Ala 
                485                 490                 495     


His Lys Ala Thr Gln Thr Glu Ser Gln Pro Trp Ile Gly Ser Glu Gly 
            500                 505                 510         


Pro Ser Gly Pro Phe Val Leu Ser Ser Pro Arg Lys Thr Ala Gln Asp 
        515                 520                 525             


Thr Leu Tyr Val Leu Pro Ser Pro Thr Ser Pro Cys Pro Ser Pro Val 
    530                 535                 540                 


Leu Val Arg Lys Arg Ala Phe Val Lys Trp Glu Asn Lys Asp Ser Leu 
545                 550                 555                 560 


Ile Lys Ser Lys Glu Glu Leu Arg His Leu Arg Leu Pro Thr Tyr Gln 
                565                 570                 575     


Glu Leu Glu Gln Asn Ser Gln Ser Cys Phe His Gly Ser Asp Leu Thr 
            580                 585                 590         


Arg Asp Cys Phe Cys Gln Val Glu Ile Ser Arg Glu Lys Thr Ser Lys 
        595                 600                 605             


Ser Phe Val Ile Ile Tyr Leu Leu Leu Gly Asn Gly Leu Phe Cys Leu 
    610                 615                 620                 


Leu Thr Thr His Lys Leu 
625                 630 

<210>  3165
<211>  3335
<212>  DNA
<213>  Homo sapiens

<400>  3165
acaaagtttg tgcctgcggt gcacctcggt cgggctcgcc gggctcgagg gctggcgggc     60

gccggggcta cgaggcccgg gggggagaga gccggcaggc ggcggcggtg gtggcggggg    120

cgatgcgccg cgcccggccg cgctaggtga gccggcaccg ggagcgcggg ccgcggccat    180

gggcaccctg ggcaaggcga gagaggctcc gcggaaacct tcccatggct gcagagctgc    240

ctctaaagca agactagagg caaagccagc caacagcccc ttcccctccc atcccagctt    300

ggcccacatc acccagttcc gaatgatggt gtctctggga catttagcca aaggagccag    360

cctggacgat ctcattgaca gctgcattca atcttttgat gcagatggaa acctgtgtcg    420

aagtaaccaa ctgttgcaag tcatgctgac catgcaccga attgtcatct cctctgcaga    480

actgctccaa aaagttatca ccccctacct ataaggatgc tttggcaaag aattcaccag    540

gactttgcct gaagatctgt tattttgtaa ggtattggat aacagaattc tgggtcatgt    600

ttaaaatgga cgccagcttg acagacacta tggaggagtt tcaggaactg gtgaaagcta    660

agggtgagga gttacattgc cgcctgattg acacaactca aatcaatgcc cgtgactggt    720

ccaggaaact tactcaaagg ataaaatcaa ataccagcaa gaaacggaaa gtctccctgc    780

tctttgacca tctggaacca gaagagctat ccgagcacct cacctacctt gagttcaagt    840

ctttccggag gatatcgttc tctgattatc agaattacct tgtaaatagc tgtgtgaagg    900

aaaaccccac catggagcga tctattgctc tgtgcaacgg catctcccag tgggtacaac    960

tgatggttct cagccgcccc acgccgcagc tccgagcaga agtcttcatc aagttcatcc   1020

aggtggctca gaagctccac caactacaga acttcaatac actgatggct gtgataggtg   1080

ggctgtgtca cagctcaatc tcgaggctca aggagacaag ttcgcatgtc ccacatgaaa   1140

tcaataaggt tctcggtgag atgactgagc tgctgtcctc ctccagaaac tacgacaatt   1200

accggcgagc ctatggagag tgcaccgact tcaagatccc cattctgggt gtgcatctca   1260

aggacctcat ctccctgtat gaagccatgc ctgactatct ggaggacggg aaagtgaacg   1320

tccataagct actggcccta tacaatcata tcagtgaatt ggtccagctg caagaggtgg   1380

ccccaccctt ggaggctaac aaggacttgg tacacttgct gacgttatcc ctggatcttt   1440

actacactga ggatgaaatc tatgagcttt cctatgcccg ggaaccaagg aaccacagag   1500

ctccaccact aacaccttca aagccaccag tagtagtgga ctgggcttct ggagtgtctc   1560

ccaaacctga tccaaaaacc attagcaaac acgtccagag gatggtggat tctgtcttca   1620

agaactatga tcacgaccag gatggataca tttctcagga agaatttgaa aagattgctg   1680

cgagttttcc attttccttc tgtgtgatgg acaaagacag ggaaggcctc atcagcaggg   1740

atgagatcac agcctacttc atgagagcca gctcaatcta ttccaagctg ggcctgggct   1800

ttcctcacaa cttccaagag accacctacc tgaagcccac tttttgtgac aactgtgctg   1860

gatttctctg gggagtgatc aaacaaggat atcgatgtaa agactgcggg atgaactgtc   1920

acaaacaatg caaagatctg gttgtgtttg agtgtaagaa gcgagccaag aacccagtag   1980

ctcccacaga gaacaacact tctgtggggc cagtgtccaa cctttgctca ttgggagcca   2040

aagatctgct ccatgcacct gaggaaggac cttttacatt ccctaatggg gaggctgtgg   2100

aacatggtga ggagagtaag gatcggacca tcatgctgat gggagtgtcc tcacagaaga   2160

tttctcttcg gctgaagagg gctgttgccc acaaggccac ccagactgaa tcacagcctt   2220

ggattggcag tgagggccct tcaggtccct ttgtgctgtc ttccccaagg aagacagccc   2280

aggatactct atatgtgctt cccagtccca cctctccatg tcctagccca gtcttggtca   2340

gaaagcgggc ttttgtcaag tgggagaata aagactccct cataaaatca aaggaggagc   2400

tccgtcacct cagactgcct acctaccaag aactggaaca ggaaataaat actctgaaag   2460

cagataatga tgccctaaag atccaactga aatatgcaca gaagaaaata gaatccctcc   2520

agcttgaaaa aagcaatcat gtcttagctc aaatggagca gggtgactgt tcttagccca   2580

gaaactaagt agcacaatct gtagatgagt atagtgatct catttcctaa actgtaatgc   2640

acagacctga ggaactttac actgaccagc tttaaaacag tactttaaaa ggaaaagcct   2700

gttactgttt atttacctaa aagattccta atgtgcagca ctgttttctc tttcagttag   2760

ttgactcaaa gggggaaaac taaagaatgc aaaacttttg ctattcatac cactgatgtt   2820

catcaaaagt atgcgatcta aaacatgact atcatttcct gacaatgggg catctcggtg   2880

gcctgcctgg ctgattcttc cttaaaacta aaatctctgg aaaatggatt tgcttcttac   2940

cctgtgtttt ctgcaaactg acttactttg ttccagccaa agcttgctaa taatagaaaa   3000

ctacccatat tccaaaagta gatttcctct gtatcccagc atactttgtg aacctggctc   3060

cttcttcact acctcagatc taatcaatta gtccatgtac cctccttcct cactacagtc   3120

ataacacatg agcatatcta cctagaagcc aatttctact gatgtagcca caacttttta   3180

gaggcctatt aaacatgacg ttatccaatt gcaggtcaac ttatagttgt agccttacaa   3240

cttacaggca tcagaaaata agtaatcaaa ttaggtacct ggaaacatag ctattaccat   3300

ctcatattac tgtctaatta aaataaacat aacgc                              3335


<210>  3166
<211>  659
<212>  PRT
<213>  Homo sapiens

<400>  3166


Met Phe Lys Met Asp Ala Ser Leu Thr Asp Thr Met Glu Glu Phe Gln 
1               5                   10                  15      


Glu Leu Val Lys Ala Lys Gly Glu Glu Leu His Cys Arg Leu Ile Asp 
            20                  25                  30          


Thr Thr Gln Ile Asn Ala Arg Asp Trp Ser Arg Lys Leu Thr Gln Arg 
        35                  40                  45              


Ile Lys Ser Asn Thr Ser Lys Lys Arg Lys Val Ser Leu Leu Phe Asp 
    50                  55                  60                  


His Leu Glu Pro Glu Glu Leu Ser Glu His Leu Thr Tyr Leu Glu Phe 
65                  70                  75                  80  


Lys Ser Phe Arg Arg Ile Ser Phe Ser Asp Tyr Gln Asn Tyr Leu Val 
                85                  90                  95      


Asn Ser Cys Val Lys Glu Asn Pro Thr Met Glu Arg Ser Ile Ala Leu 
            100                 105                 110         


Cys Asn Gly Ile Ser Gln Trp Val Gln Leu Met Val Leu Ser Arg Pro 
        115                 120                 125             


Thr Pro Gln Leu Arg Ala Glu Val Phe Ile Lys Phe Ile Gln Val Ala 
    130                 135                 140                 


Gln Lys Leu His Gln Leu Gln Asn Phe Asn Thr Leu Met Ala Val Ile 
145                 150                 155                 160 


Gly Gly Leu Cys His Ser Ser Ile Ser Arg Leu Lys Glu Thr Ser Ser 
                165                 170                 175     


His Val Pro His Glu Ile Asn Lys Val Leu Gly Glu Met Thr Glu Leu 
            180                 185                 190         


Leu Ser Ser Ser Arg Asn Tyr Asp Asn Tyr Arg Arg Ala Tyr Gly Glu 
        195                 200                 205             


Cys Thr Asp Phe Lys Ile Pro Ile Leu Gly Val His Leu Lys Asp Leu 
    210                 215                 220                 


Ile Ser Leu Tyr Glu Ala Met Pro Asp Tyr Leu Glu Asp Gly Lys Val 
225                 230                 235                 240 


Asn Val His Lys Leu Leu Ala Leu Tyr Asn His Ile Ser Glu Leu Val 
                245                 250                 255     


Gln Leu Gln Glu Val Ala Pro Pro Leu Glu Ala Asn Lys Asp Leu Val 
            260                 265                 270         


His Leu Leu Thr Leu Ser Leu Asp Leu Tyr Tyr Thr Glu Asp Glu Ile 
        275                 280                 285             


Tyr Glu Leu Ser Tyr Ala Arg Glu Pro Arg Asn His Arg Ala Pro Pro 
    290                 295                 300                 


Leu Thr Pro Ser Lys Pro Pro Val Val Val Asp Trp Ala Ser Gly Val 
305                 310                 315                 320 


Ser Pro Lys Pro Asp Pro Lys Thr Ile Ser Lys His Val Gln Arg Met 
                325                 330                 335     


Val Asp Ser Val Phe Lys Asn Tyr Asp His Asp Gln Asp Gly Tyr Ile 
            340                 345                 350         


Ser Gln Glu Glu Phe Glu Lys Ile Ala Ala Ser Phe Pro Phe Ser Phe 
        355                 360                 365             


Cys Val Met Asp Lys Asp Arg Glu Gly Leu Ile Ser Arg Asp Glu Ile 
    370                 375                 380                 


Thr Ala Tyr Phe Met Arg Ala Ser Ser Ile Tyr Ser Lys Leu Gly Leu 
385                 390                 395                 400 


Gly Phe Pro His Asn Phe Gln Glu Thr Thr Tyr Leu Lys Pro Thr Phe 
                405                 410                 415     


Cys Asp Asn Cys Ala Gly Phe Leu Trp Gly Val Ile Lys Gln Gly Tyr 
            420                 425                 430         


Arg Cys Lys Asp Cys Gly Met Asn Cys His Lys Gln Cys Lys Asp Leu 
        435                 440                 445             


Val Val Phe Glu Cys Lys Lys Arg Ala Lys Asn Pro Val Ala Pro Thr 
    450                 455                 460                 


Glu Asn Asn Thr Ser Val Gly Pro Val Ser Asn Leu Cys Ser Leu Gly 
465                 470                 475                 480 


Ala Lys Asp Leu Leu His Ala Pro Glu Glu Gly Pro Phe Thr Phe Pro 
                485                 490                 495     


Asn Gly Glu Ala Val Glu His Gly Glu Glu Ser Lys Asp Arg Thr Ile 
            500                 505                 510         


Met Leu Met Gly Val Ser Ser Gln Lys Ile Ser Leu Arg Leu Lys Arg 
        515                 520                 525             


Ala Val Ala His Lys Ala Thr Gln Thr Glu Ser Gln Pro Trp Ile Gly 
    530                 535                 540                 


Ser Glu Gly Pro Ser Gly Pro Phe Val Leu Ser Ser Pro Arg Lys Thr 
545                 550                 555                 560 


Ala Gln Asp Thr Leu Tyr Val Leu Pro Ser Pro Thr Ser Pro Cys Pro 
                565                 570                 575     


Ser Pro Val Leu Val Arg Lys Arg Ala Phe Val Lys Trp Glu Asn Lys 
            580                 585                 590         


Asp Ser Leu Ile Lys Ser Lys Glu Glu Leu Arg His Leu Arg Leu Pro 
        595                 600                 605             


Thr Tyr Gln Glu Leu Glu Gln Glu Ile Asn Thr Leu Lys Ala Asp Asn 
    610                 615                 620                 


Asp Ala Leu Lys Ile Gln Leu Lys Tyr Ala Gln Lys Lys Ile Glu Ser 
625                 630                 635                 640 


Leu Gln Leu Glu Lys Ser Asn His Val Leu Ala Gln Met Glu Gln Gly 
                645                 650                 655     


Asp Cys Ser 
            

<210>  3167
<211>  3594
<212>  DNA
<213>  Homo sapiens

<400>  3167
acaaagtttg tgcctgcggt gcacctcggt cgggctcgcc gggctcgagg gctggcgggc     60

gccggggcta cgaggcccgg gggggagaga gccggcaggc ggcggcggtg gtggcggggg    120

cgatgcgccg cgcccggccg cgctaggtga gccggcaccg ggagcgcggg ccgcggccat    180

gggcaccctg ggcaaggcga gagaggctcc gcggaaacct tcccatggct gcagagctgc    240

ctctaaagca agactagagg caaagccagc caacagcccc ttcccctccc atcccagctt    300

ggcccacatc acccagttcc gaatgatggt gtctctggga catttagcca aaggagccag    360

cctggacgat ctcattgaca gctgcattca atcttttgat gcagatggaa acctgtgtcg    420

aagtaaccaa ctgttgcaag tcatgctgac catgcaccga attgtcatct cctctgcaga    480

actgctccaa aaagttatca ccccctacct ataaggatgc tttggcaaag aattcaccag    540

gactttgcct gaagatctgt tattttgtaa ggtattggat aacagaattc tgggtcatgt    600

ttaaaatgga cgccagcttg acagacacta tggaggagtt tcaggaactg gtgaaagcta    660

agggtgagga gttacattgc cgcctgattg acacaactca aatcaatgcc cgtgactggt    720

ccaggaaact tactcaaagg ataaaatcaa ataccagcaa gaaacggaaa gtctccctgc    780

tctttgacca tctggaacca gaagagctat ccgagcacct cacctacctt gagttcaagt    840

ctttccggag gatatcgttc tctgattatc agaattacct tgtaaatagc tgtgtgaagg    900

aaaaccccac catggagcga tctattgctc tgtgcaacgg catctcccag tgggtacaac    960

tgatggttct cagccgcccc acgccgcagc tccgagcaga agtcttcatc aagttcatcc   1020

aggtggctca gaagctccac caactacaga acttcaatac actgatggct gtgataggtg   1080

ggctgtgtca cagctcaatc tcgaggctca aggagacaag ttcgcatgtc ccacatgaaa   1140

tcaataaggt tctcggtgag atgactgagc tgctgtcctc ctccagaaac tacgacaatt   1200

accggcgagc ctatggagag tgcaccgact tcaagatccc cattctgggt gtgcatctca   1260

aggacctcat ctccctgtat gaagccatgc ctgactatct ggaggacggg aaagtgaacg   1320

tccataagct actggcccta tacaatcata tcagtgaatt ggtccagctg caagaggtgg   1380

ccccaccctt ggaggctaac aaggacttgg tacacttgct gacgttatcc ctggatcttt   1440

actacactga ggatgaaatc tatgagcttt cctatgcccg ggaaccaagg aaccacagag   1500

ctccatctgt cttcaagaac tatgatcacg accaggatgg atacatttct caggaagaat   1560

ttgaaaagat tgctgcgagt tttccatttt ccttctgtgt gatggacaaa gacagggaag   1620

gcctcatcag cagggatgag atcacagcct acttcatgag agccagctca atctattcca   1680

agctgggcct gggctttcct cacaacttcc aagagaccac ctacctgaag cccacttttt   1740

gtgacaactg tgctggattt ctctggggag tgatcaaaca aggatatcga tgtaaagact   1800

gcgggatgaa ctgtcacaaa caatgcaaag atctggttgt gtttgagtgt aagaagcgag   1860

ccaagaaccc agtagctccc acagagaaca acacttctgt ggggccagtg tccaaccttt   1920

gctcattggg agccaaagat ctgctccatg cacctgagga aggacctttt acattcccta   1980

atggggaggc tgtggaacat ggtgaggaga gtaaggatcg gaccatcatg ctgatgggag   2040

tgtcctcaca gaagatttct cttcggctga agagggctgt tgcccacaag gccacccaga   2100

ctgaatcaca gccttggatt ggcagtgagg gcccttcagg tccctttgtg ctgtcttccc   2160

caaggaagac agcccaggat actctatatg tgcttcccag tcccacctct ccatgtccta   2220

gcccagtctt ggtcagaaag cgggcttttg tcaagtggga gaataaagac tccctcataa   2280

aatcaaagga ggagctccgt cacctcagac tgcctaccta ccaagaactg gaacagaatt   2340

ctcagtcatg ctttcatggc tcagacctga ccagagactg tttctgccaa gttgagatct   2400

cccgcgagaa aacatccaaa agttttgtca ttatctacct attgctcgga aatggtttat   2460

tctgcctgct aaccactcac aaactttgat atgataacaa agactaactg ctgcttacaa   2520

atgctcgttt gatatttaac ttgctatttt ctattcaggg caaaataact atcttgaaaa   2580

tggttgttaa ttctcagcca cagtgaatag gaaatgccaa tcaaaagtag ctctcaattt   2640

gtaattcatt tgctattcat tgctgcttta ttaacatacc tcattctcct ttccctttag   2700

gaaataaata ctctgaaagc agataatgat gccctaaaga tccaactgaa atatgcacag   2760

aagaaaatag aatccctcca gcttgaaaaa agcaatcatg tcttagctca aatggagcag   2820

ggtgactgtt cttagcccag aaactaagta gcacaatctg tagatgagta tagtgatctc   2880

atttcctaaa ctgtaatgca cagacctgag gaactttaca ctgaccagct ttaaaacagt   2940

actttaaaag gaaaagcctg ttactgttta tttacctaaa agattcctaa tgtgcagcac   3000

tgttttctct ttcagttagt tgactcaaag ggggaaaact aaagaatgca aaacttttgc   3060

tattcatacc actgatgttc atcaaaagta tgcgatctaa aacatgacta tcatttcctg   3120

acaatggggc atctcggtgg cctgcctggc tgattcttcc ttaaaactaa aatctctgga   3180

aaatggattt gcttcttacc ctgtgttttc tgcaaactga cttactttgt tccagccaaa   3240

gcttgctaat aatagaaaac tacccatatt ccaaaagtag atttcctctg tatcccagca   3300

tactttgtga acctggctcc ttcttcacta cctcagatct aatcaattag tccatgtacc   3360

ctccttcctc actacagtca taacacatga gcatatctac ctagaagcca atttctactg   3420

atgtagccac aactttttag aggcctatta aacatgacgt tatccaattg caggtcaact   3480

tatagttgta gccttacaac ttacaggcat cagaaaataa gtaatcaaat taggtacctg   3540

gaaacatagc tattaccatc tcatattact gtctaattaa aataaacata acgc         3594


<210>  3168
<211>  630
<212>  PRT
<213>  Homo sapiens

<400>  3168


Met Phe Lys Met Asp Ala Ser Leu Thr Asp Thr Met Glu Glu Phe Gln 
1               5                   10                  15      


Glu Leu Val Lys Ala Lys Gly Glu Glu Leu His Cys Arg Leu Ile Asp 
            20                  25                  30          


Thr Thr Gln Ile Asn Ala Arg Asp Trp Ser Arg Lys Leu Thr Gln Arg 
        35                  40                  45              


Ile Lys Ser Asn Thr Ser Lys Lys Arg Lys Val Ser Leu Leu Phe Asp 
    50                  55                  60                  


His Leu Glu Pro Glu Glu Leu Ser Glu His Leu Thr Tyr Leu Glu Phe 
65                  70                  75                  80  


Lys Ser Phe Arg Arg Ile Ser Phe Ser Asp Tyr Gln Asn Tyr Leu Val 
                85                  90                  95      


Asn Ser Cys Val Lys Glu Asn Pro Thr Met Glu Arg Ser Ile Ala Leu 
            100                 105                 110         


Cys Asn Gly Ile Ser Gln Trp Val Gln Leu Met Val Leu Ser Arg Pro 
        115                 120                 125             


Thr Pro Gln Leu Arg Ala Glu Val Phe Ile Lys Phe Ile Gln Val Ala 
    130                 135                 140                 


Gln Lys Leu His Gln Leu Gln Asn Phe Asn Thr Leu Met Ala Val Ile 
145                 150                 155                 160 


Gly Gly Leu Cys His Ser Ser Ile Ser Arg Leu Lys Glu Thr Ser Ser 
                165                 170                 175     


His Val Pro His Glu Ile Asn Lys Val Leu Gly Glu Met Thr Glu Leu 
            180                 185                 190         


Leu Ser Ser Ser Arg Asn Tyr Asp Asn Tyr Arg Arg Ala Tyr Gly Glu 
        195                 200                 205             


Cys Thr Asp Phe Lys Ile Pro Ile Leu Gly Val His Leu Lys Asp Leu 
    210                 215                 220                 


Ile Ser Leu Tyr Glu Ala Met Pro Asp Tyr Leu Glu Asp Gly Lys Val 
225                 230                 235                 240 


Asn Val His Lys Leu Leu Ala Leu Tyr Asn His Ile Ser Glu Leu Val 
                245                 250                 255     


Gln Leu Gln Glu Val Ala Pro Pro Leu Glu Ala Asn Lys Asp Leu Val 
            260                 265                 270         


His Leu Leu Thr Leu Ser Leu Asp Leu Tyr Tyr Thr Glu Asp Glu Ile 
        275                 280                 285             


Tyr Glu Leu Ser Tyr Ala Arg Glu Pro Arg Asn His Arg Ala Pro Ser 
    290                 295                 300                 


Val Phe Lys Asn Tyr Asp His Asp Gln Asp Gly Tyr Ile Ser Gln Glu 
305                 310                 315                 320 


Glu Phe Glu Lys Ile Ala Ala Ser Phe Pro Phe Ser Phe Cys Val Met 
                325                 330                 335     


Asp Lys Asp Arg Glu Gly Leu Ile Ser Arg Asp Glu Ile Thr Ala Tyr 
            340                 345                 350         


Phe Met Arg Ala Ser Ser Ile Tyr Ser Lys Leu Gly Leu Gly Phe Pro 
        355                 360                 365             


His Asn Phe Gln Glu Thr Thr Tyr Leu Lys Pro Thr Phe Cys Asp Asn 
    370                 375                 380                 


Cys Ala Gly Phe Leu Trp Gly Val Ile Lys Gln Gly Tyr Arg Cys Lys 
385                 390                 395                 400 


Asp Cys Gly Met Asn Cys His Lys Gln Cys Lys Asp Leu Val Val Phe 
                405                 410                 415     


Glu Cys Lys Lys Arg Ala Lys Asn Pro Val Ala Pro Thr Glu Asn Asn 
            420                 425                 430         


Thr Ser Val Gly Pro Val Ser Asn Leu Cys Ser Leu Gly Ala Lys Asp 
        435                 440                 445             


Leu Leu His Ala Pro Glu Glu Gly Pro Phe Thr Phe Pro Asn Gly Glu 
    450                 455                 460                 


Ala Val Glu His Gly Glu Glu Ser Lys Asp Arg Thr Ile Met Leu Met 
465                 470                 475                 480 


Gly Val Ser Ser Gln Lys Ile Ser Leu Arg Leu Lys Arg Ala Val Ala 
                485                 490                 495     


His Lys Ala Thr Gln Thr Glu Ser Gln Pro Trp Ile Gly Ser Glu Gly 
            500                 505                 510         


Pro Ser Gly Pro Phe Val Leu Ser Ser Pro Arg Lys Thr Ala Gln Asp 
        515                 520                 525             


Thr Leu Tyr Val Leu Pro Ser Pro Thr Ser Pro Cys Pro Ser Pro Val 
    530                 535                 540                 


Leu Val Arg Lys Arg Ala Phe Val Lys Trp Glu Asn Lys Asp Ser Leu 
545                 550                 555                 560 


Ile Lys Ser Lys Glu Glu Leu Arg His Leu Arg Leu Pro Thr Tyr Gln 
                565                 570                 575     


Glu Leu Glu Gln Asn Ser Gln Ser Cys Phe His Gly Ser Asp Leu Thr 
            580                 585                 590         


Arg Asp Cys Phe Cys Gln Val Glu Ile Ser Arg Glu Lys Thr Ser Lys 
        595                 600                 605             


Ser Phe Val Ile Ile Tyr Leu Leu Leu Gly Asn Gly Leu Phe Cys Leu 
    610                 615                 620                 


Leu Thr Thr His Lys Leu 
625                 630 

<210>  3169
<211>  2397
<212>  DNA
<213>  Homo sapiens

<400>  3169
acaaagtttg tgcctgcggt gcacctcggt cgggctcgcc gggctcgagg gctggcgggc     60

gccggggcta cgaggcccgg gggggagaga gccggcaggc ggcggcggtg gtggcggggg    120

cgatgcgccg cgcccggccg cgctaggtga gccggcaccg ggagcgcggg ccgcggccat    180

gggcaccctg ggcaaggcga gagaggctcc gcggaaacct tcccatggct gcagagctgc    240

ctctaaagca agactagagg caaagccagc caacagcccc ttcccctccc atcccagctt    300

ggcccacatc acccagttcc gaatgatggt gtctctggga catttagcca aaggagccag    360

cctggacgat ctcattgaca gctgcattca atcttttgat gcagatggaa acctgtgtcg    420

aagtaaccaa ctgttgcaag tcatgctgac catgcaccga attgtcatct cctctgcaga    480

actgctccaa aaagttatca ccccctacct ataaggatgc tttggcaaag aattcaccag    540

gactttgcct gaagatctgt tattttgtaa ggtattggat aacagaattc tgggtcatgt    600

ttaaaatgga cgccagcttg acagacacta tggaggagtt tcaggaactg gtgaaagcta    660

agggtgagga gttacattgc cgcctgattg acacaactca aatcaatgcc cgtgactggt    720

ccaggaaact tactcaaagg ataaaatcaa ataccagcaa gaaacggaaa gtctccctgc    780

tctttgacca tctggaacca gaagagctat ccgagcacct cacctacctt gagttcaagt    840

ctttccggag gatatcgttc tctgattatc agaattacct tgtaaatagc tgtgtgaagg    900

aaaaccccac catggagcga tctattgctc tgtgcaacgg catctcccag tgggtacaac    960

tgatggttct cagccgcccc acgccgcagc tccgagcaga agtcttcatc aagttcatcc   1020

aggtggctca gaagctccac caactacaga acttcaatac actgatggct gtgataggtg   1080

ggctgtgtca cagctcaatc tcgaggctca aggagacaag ttcgcatgtc ccacatgaaa   1140

tcaataaggt tctcggtgag atgactgagc tgctgtcctc ctccagaaac tacgacaatt   1200

accggcgagc ctatggagag tgcaccgact tcaagatccc cattctgggt gtgcatctca   1260

aggacctcat ctccctgtat gaagccatgc ctgactatct ggaggacggg aaagtgaacg   1320

tccataagct actggcccta tacaatcata tcagtgaatt ggtccagctg caagaggtgg   1380

ccccaccctt ggaggctaac aaggacttgg tacacttgct gacgttatcc ctggatcttt   1440

actacactga ggatgaaatc tatgagcttt cctatgcccg ggaaccaagg aaccacagag   1500

ctccaccact aacaccttca aagccaccag tagtagtgga ctgggcttct ggagtgtctc   1560

ccaaacctga tccaaaaacc attagcaaac acgtccagag gatggtggat tctgtcttca   1620

agaactatga tcacgaccag gatggataca tttctcagga agaatttgaa aagattgctg   1680

cgagttttcc attttccttc tgtgtgatgg acaaagacag ggaaggcctc atcagcaggg   1740

atgagatcac agcctacttc atgagagcca gctcaatcta ttccaagctg ggcctgggct   1800

ttcctcacaa cttccaagag accacctacc tgaagcccac tttttgtgac aactgtgctg   1860

gatttctctg gggagtgatc aaacaaggat atcgatgtaa agactgcggg atgaactgtc   1920

acaaacaatg caaagatctg gttgtgtttg agtgtaagaa gcgagccaag aacccagtag   1980

ctcccacaga gaacaacact tctgtggggc cagtgtccaa cctttgctca ttgggagcca   2040

aagatctgct ccatgcacct gaggaaggac cttttacatt ccctaatggg gaggctgtgg   2100

aacatggtga ggagagtaag gatcggacca tcatgctgat gggagtgtcc tcacagaaga   2160

tttctcttcg gctgaagagg gctgttgccc acaaggccac ccagactgaa tcacagcctt   2220

ggattggcag tgagggccct tcaggtccct ttgtgctgtc ttccccaagg aagacagccc   2280

aggatactct atatgtgctt cccagtccca cctctccatg tcctagccca gtcttggtca   2340

gaaagcgggc ttttgtcaag tgggagaata aagactccct cataaaatca aaggagg      2397


<210>  3170
<211>  599
<212>  PRT
<213>  Homo sapiens

<400>  3170


Met Phe Lys Met Asp Ala Ser Leu Thr Asp Thr Met Glu Glu Phe Gln 
1               5                   10                  15      


Glu Leu Val Lys Ala Lys Gly Glu Glu Leu His Cys Arg Leu Ile Asp 
            20                  25                  30          


Thr Thr Gln Ile Asn Ala Arg Asp Trp Ser Arg Lys Leu Thr Gln Arg 
        35                  40                  45              


Ile Lys Ser Asn Thr Ser Lys Lys Arg Lys Val Ser Leu Leu Phe Asp 
    50                  55                  60                  


His Leu Glu Pro Glu Glu Leu Ser Glu His Leu Thr Tyr Leu Glu Phe 
65                  70                  75                  80  


Lys Ser Phe Arg Arg Ile Ser Phe Ser Asp Tyr Gln Asn Tyr Leu Val 
                85                  90                  95      


Asn Ser Cys Val Lys Glu Asn Pro Thr Met Glu Arg Ser Ile Ala Leu 
            100                 105                 110         


Cys Asn Gly Ile Ser Gln Trp Val Gln Leu Met Val Leu Ser Arg Pro 
        115                 120                 125             


Thr Pro Gln Leu Arg Ala Glu Val Phe Ile Lys Phe Ile Gln Val Ala 
    130                 135                 140                 


Gln Lys Leu His Gln Leu Gln Asn Phe Asn Thr Leu Met Ala Val Ile 
145                 150                 155                 160 


Gly Gly Leu Cys His Ser Ser Ile Ser Arg Leu Lys Glu Thr Ser Ser 
                165                 170                 175     


His Val Pro His Glu Ile Asn Lys Val Leu Gly Glu Met Thr Glu Leu 
            180                 185                 190         


Leu Ser Ser Ser Arg Asn Tyr Asp Asn Tyr Arg Arg Ala Tyr Gly Glu 
        195                 200                 205             


Cys Thr Asp Phe Lys Ile Pro Ile Leu Gly Val His Leu Lys Asp Leu 
    210                 215                 220                 


Ile Ser Leu Tyr Glu Ala Met Pro Asp Tyr Leu Glu Asp Gly Lys Val 
225                 230                 235                 240 


Asn Val His Lys Leu Leu Ala Leu Tyr Asn His Ile Ser Glu Leu Val 
                245                 250                 255     


Gln Leu Gln Glu Val Ala Pro Pro Leu Glu Ala Asn Lys Asp Leu Val 
            260                 265                 270         


His Leu Leu Thr Leu Ser Leu Asp Leu Tyr Tyr Thr Glu Asp Glu Ile 
        275                 280                 285             


Tyr Glu Leu Ser Tyr Ala Arg Glu Pro Arg Asn His Arg Ala Pro Pro 
    290                 295                 300                 


Leu Thr Pro Ser Lys Pro Pro Val Val Val Asp Trp Ala Ser Gly Val 
305                 310                 315                 320 


Ser Pro Lys Pro Asp Pro Lys Thr Ile Ser Lys His Val Gln Arg Met 
                325                 330                 335     


Val Asp Ser Val Phe Lys Asn Tyr Asp His Asp Gln Asp Gly Tyr Ile 
            340                 345                 350         


Ser Gln Glu Glu Phe Glu Lys Ile Ala Ala Ser Phe Pro Phe Ser Phe 
        355                 360                 365             


Cys Val Met Asp Lys Asp Arg Glu Gly Leu Ile Ser Arg Asp Glu Ile 
    370                 375                 380                 


Thr Ala Tyr Phe Met Arg Ala Ser Ser Ile Tyr Ser Lys Leu Gly Leu 
385                 390                 395                 400 


Gly Phe Pro His Asn Phe Gln Glu Thr Thr Tyr Leu Lys Pro Thr Phe 
                405                 410                 415     


Cys Asp Asn Cys Ala Gly Phe Leu Trp Gly Val Ile Lys Gln Gly Tyr 
            420                 425                 430         


Arg Cys Lys Asp Cys Gly Met Asn Cys His Lys Gln Cys Lys Asp Leu 
        435                 440                 445             


Val Val Phe Glu Cys Lys Lys Arg Ala Lys Asn Pro Val Ala Pro Thr 
    450                 455                 460                 


Glu Asn Asn Thr Ser Val Gly Pro Val Ser Asn Leu Cys Ser Leu Gly 
465                 470                 475                 480 


Ala Lys Asp Leu Leu His Ala Pro Glu Glu Gly Pro Phe Thr Phe Pro 
                485                 490                 495     


Asn Gly Glu Ala Val Glu His Gly Glu Glu Ser Lys Asp Arg Thr Ile 
            500                 505                 510         


Met Leu Met Gly Val Ser Ser Gln Lys Ile Ser Leu Arg Leu Lys Arg 
        515                 520                 525             


Ala Val Ala His Lys Ala Thr Gln Thr Glu Ser Gln Pro Trp Ile Gly 
    530                 535                 540                 


Ser Glu Gly Pro Ser Gly Pro Phe Val Leu Ser Ser Pro Arg Lys Thr 
545                 550                 555                 560 


Ala Gln Asp Thr Leu Tyr Val Leu Pro Ser Pro Thr Ser Pro Cys Pro 
                565                 570                 575     


Ser Pro Val Leu Val Arg Lys Arg Ala Phe Val Lys Trp Glu Asn Lys 
            580                 585                 590         


Asp Ser Leu Ile Lys Ser Lys 
        595                 

<210>  3171
<211>  3315
<212>  DNA
<213>  Homo sapiens

<400>  3171
tcctgaagta cggggccttc gtccctcctg agctcttcgg ctccgagttc ttcatgggac     60

ggctgatgag gaggatcccg gagccccgga tctgctttct ggaagccatc tggagcaaca    120

ttttctccct gaacctgctg gatgcctggt atgacctcac cagttctggg gagtcctgga    180

aacagcacat caaggacaag accaggagct tagagaagga gcccctgacc acctcgggga    240

cctcctcgcg gctggaggcc tcgtggctgc agccaggcac ggcgctggcc caggcattta    300

aaggcttcct gacaggcagg cccctccacc agcgcagccc caacttcctc cagggcctcc    360

agctgcacca ggactactgt agccacaaag acttctccac ctgggcagac taccagcttg    420

actccatgcc cagccagctg acccccaagg agccccggct ctgcctggtg gacgccgcct    480

acttcatcaa caccagctct ccctccatgt tccggccagg ccgcaggctg gacctcatcc    540

tctccttcga ctactcccta tctgcgccct tcgaggtacc ctggtcaccc caggggaacc    600

cctctgccca gccaggccaa gctccagagg cgagcagcag ggccactgag cccctgcccc    660

acaccgccgg ggtcccgaag ggaaggagag gtgtcaggcc ttgatctgct ggctcctgcc    720

agggtcctta ggtgggaagg ctggggtggt gcaggggcct tgggctccca ggacaggtga    780

acagggaggg acctccccac acctactcca aagaacagct ggacggagct gagaggagac    840

cctagcatct ccatgtccat cccccagacc tcccctgaga cgctgtgcca atgtgggtct    900

cctctcggct ctgggatttg aacagtccag caatagcaat ccagaattgg ggttttgggg    960

ggctggggga tgggtctgac cccacctaga gcttttaacc aaacaacatt gcagaccacc   1020

agagtccttg gactccccct gggtctccct ccgagtcact ctgcagcttg gcccgaccac   1080

aaacaggaca gagccaggct gttgtcttga cactgaagca gctggtgtgg gctggaactg   1140

gcccagcatt gacctgggcc gggctggttc tctccgggcc accttctccc caccaggcac   1200

tgcagcagac ggagctgtac tgccgggccc gggggctgcc cttcccccgg gtggaaccca   1260

gccctcagga ccagcaccag ccaagggaat gccacctctt ctcagacccc gcctgccccg   1320

aggccccgat cctgctgcac ttcccgctgg tcaatgcctc cttcaaggac cactcagccc   1380

ccggtgtcca gcgcagcccc gcagagctcc agggtggcca agtggatctc accggggcca   1440

cctgccccta caccctgtcc aacatgacct acaaggagga agacttcgag cgcctgctgc   1500

ggctcagtga ctacaacgtg cagaccagcc agggtgccat cctgcaggcc ctgaggaccg   1560

cgctgaagca ccggactcta gaggcgaggc ctccaagggc acagacctga ggttgctcag   1620

aggctgcagg accctccagg gcctgcgggc ataacctgat ctgtagctgg gctcagccac   1680

aggccttcct ggttggagtt ctgggctctc ccaggcctgg gtggcctctg tagctggtct   1740

cactgcccag agggaactgc acacacagac ttctctctta cgttcatggc tggcttgaga   1800

tgagttgaaa ataacttcgc caggccagtg tgtagaacag ctggtccaac cagacagact   1860

ttcacaccac aattacttcc atgcctgagc aggatagatt tgaagtgcaa gccggaggca   1920

gcagatcagg agtagggaca ggaaggacag gggatgcctg acctgacagg tggcttcagg   1980

cctcgggaat cacaagacat cctgaacaca ttgcctcctc atcttcttcc tgctcctcca   2040

cctcctcctc tccttgtcct tctcctcttt gtcctcctgc tttccgtatc caagtcttgt   2100

acttgtttaa atttattcct aaatatttta ttctttttga taagtggagt tactttctta   2160

atttcattta gattattcat tgctatttta tagaaataca atggattttt aaatgttgat   2220

cttgtattcc gcaatcttgc tgaagttgtt taccggctct aatacttttg cggatttctt   2280

agaattttct gtagacagat catgccatct ccaaatagag atggttttac ttcttcctgt   2340

ctgatctgaa tgccttttat ttatttttcc caattgccct gagcagtaca atgatgaaca   2400

cacgtttcaa gagcagacat cttgtcttgt tcctgactct gacaagaaag cataagtctc   2460

tcaccattta gtgtgatttt agctgtgggt ttttcttgga catccttatc aggttgagaa   2520

agttctcttt tatttctagt ttattgagtg ttttatgatg aaacggtgtt aggttttgtc   2580

aagtgatttt tctgtgtcta tgggcatgat catgtggttt tgtcgtgtat tttattaatg   2640

tactctattg cattaattgg tttttggata ttaaaccaac tttgcattcc tggggcagtt   2700

tccatttgat tatggtatat aaaccttttt gtttattgct ggcacatttc tttttctttt   2760

tctttctttt tttttttttt tgagacagaa tctcatcaca ctctgtcacc caggccaagt   2820

tcaatggtgc aatctggctc actgcatcct caacttcctg ggctcaagtg atccttccac   2880

ttcagcctcc caagtagctg ggactacagg catgtaacac catacttggc taaattaaaa   2940

aaatggtttt ttgtagagat gaggtctcac catgttgccc aggctggtct tgaactcctg   3000

aactcaagca atcctcctgc ctcagcctcc caaagtgctg ggattactgg tgtgagccac   3060

cacggccagc tgctagcaca tttcttacct ccctcatgca agggtgcgtg tacacataca   3120

cacacacaca cacctggccc caggtggggg ttgtagtgag agcttcggga cagaccttgg   3180

ctcagggact gccctcatct gatgtcctct ctcagcttcc ttccctgtgc ctcttctgca   3240

tttggcttta ttttgattct tcactttttc cctttatcat ggactcttat ttttttaaca   3300

gtgatatggg aattg                                                    3315


<210>  3172
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  3172


Met Gly Arg Leu Met Arg Arg Ile Pro Glu Pro Arg Ile Cys Phe Leu 
1               5                   10                  15      


Glu Ala Ile Trp Ser Asn Ile Phe Ser Leu Asn Leu Leu Asp Ala Trp 
            20                  25                  30          


Tyr Asp Leu Thr Ser Ser Gly Glu Ser Trp Lys Gln His Ile Lys Asp 
        35                  40                  45              


Lys Thr Arg Ser Leu Glu Lys Glu Pro Leu Thr Thr Ser Gly Thr Ser 
    50                  55                  60                  


Ser Arg Leu Glu Ala Ser Trp Leu Gln Pro Gly Thr Ala Leu Ala Gln 
65                  70                  75                  80  


Ala Phe Lys Gly Phe Leu Thr Gly Arg Pro Leu His Gln Arg Ser Pro 
                85                  90                  95      


Asn Phe Leu Gln Gly Leu Gln Leu His Gln Asp Tyr Cys Ser His Lys 
            100                 105                 110         


Asp Phe Ser Thr Trp Ala Asp Tyr Gln Leu Asp Ser Met Pro Ser Gln 
        115                 120                 125             


Leu Thr Pro Lys Glu Pro Arg Leu Cys Leu Val Asp Ala Ala Tyr Phe 
    130                 135                 140                 


Ile Asn Thr Ser Ser Pro Ser Met Phe Arg Pro Gly Arg Arg Leu Asp 
145                 150                 155                 160 


Leu Ile Leu Ser Phe Asp Tyr Ser Leu Ser Ala Pro Phe Glu Val Pro 
                165                 170                 175     


Trp Ser Pro Gln Gly Asn Pro Ser Ala Gln Pro Gly Gln Ala Pro Glu 
            180                 185                 190         


Ala Ser Ser Arg Ala Thr Glu Pro Leu Pro His Thr Ala Gly Val Pro 
        195                 200                 205             


Lys Gly Arg Arg Gly Val Arg Pro 
    210                 215     

<210>  3173
<211>  3580
<212>  DNA
<213>  Homo sapiens

<400>  3173
gtcctatccc actgggaccg tcgctgccac tcagccagag agccagcatc ttggcaaggg     60

ctgggcctgg agtgaagctg gaagggctag catggagagc ctgtcacctg ggggaccacc    120

tggccaccct taccaggggg aggcctctac ctgctggcag ctcacagtga gggtcctgga    180

ggcgcggaac ctgcgctggg ctgacctgtt gagtgaggcc gacccttacg tgatcctaca    240

gctgtcgacc gcacctggaa tgaagtttaa gaccaagacg ctcaccgaca ccagtcatcc    300

tgtgtggaat gaggccttcc gtttccttat ccaaagtcag gtcaagaatg ttctggagct    360

tagcatctat gatgaggact cagtcacgga ggatgacatc tgcttcaagg ttctctatga    420

catctcagaa gtcctccctg gcaagctgct ccggaaaacc ttctcccaga gtccccaggg    480

agaggaggag ctggatgtgg agttcctgat ggaagaaacg tcagatcgcc cagaaaacct    540

catcaccaac aaagtcattg tggcccgaga gctgtcatgc ctggatgtgc atctggacag    600

cacagggagc accgctgtgg ttgcagatca ggacaagctg gagctggagc tggtgctgaa    660

ggggtcctat gaggacacac agacatcctt cctgggcaca gcctctgcct tccgcttcca    720

ctacatggca gccctagaga cagagctgag cgggcgcctg aggagctcca gaagcaatgg    780

ctggaatggg gacaactcag ctgggtacct cactgtgccc ctgaggccct tgaccattgg    840

gaaggaggtg actatggatg ttcctgctcc aaatgcccca ggagtgaggc tgcagctcaa    900

ggcagagggc tgccctgagg agctggccgt gcacctgggc ttcaatctct gtgcagagga    960

gcaggccttc ctgagcagga ggaagcaggt ggtggccaag gccctgaagc aggccctgca   1020

gctggacaga gacctgcagg aggatgaggt acccgttgtg ggcatcatgg ccacaggagg   1080

aggtgcccgg gccatgacct cactctacgg ccacctattg gccttgcaga agctgggcct   1140

cctagactgt gtgacctact tcagtggcat ctctggctct acgtggacaa tggcccacct   1200

gtacggggac cctgagtggt cgcagaggga cctggaggga cctatcagat acgcccggga   1260

gcacctggcc aagagcaagc tggaggtctt ttccccagag cgcctggcga gctaccgccg   1320

ggagctggag ctgcgggctg agcagggcca ccccacgacc tttgtggacc tgtgggcgct   1380

agtgctggag tccatgctgc acggccaggt gatggatcag aagctgtcag gacagagagc   1440

cgccctggaa cggggtcaga accctctgcc cctctacttg agcctcaatg tcaaagagaa   1500

caatctggag acactggact tcaaggagtg ggttgagttc tccccctatg aggtcggttt   1560

cctgaagtac ggggccttcg tccctcctga gctcttcggc tccgagttct tcatgggacg   1620

gctgatgagg aggatcccgg agccccggat ctgctttctg gaagccatct ggagcaacat   1680

tttctccctg aacctgctgg atgcctggta tgacctcacc agttctgggg agtcctggaa   1740

acagcacatc aaggacaaga ccaggagctt agagaaggag cccctgacca cctcggggac   1800

ctcctcgcgg ctggaggcct cgtggctgca gccaggcacg gcgctggccc aggcatttaa   1860

aggcttcctg acaggcaggc ccctccacca gcgcagcccc aacttcctcc agggcctcca   1920

gctgcaccag gactactgta gccacaaaga cttctccacc tgggcagact accagcttga   1980

ctccatgccc agccagctga cccccaagga gccccggctc tgcctggtgg acgccgccta   2040

cttcatcaac accagctctc cctccatgtt ccggccaggc cgcaggctgg acctcatcct   2100

ctccttcgac tactccctat ctgcgccctt cgaggcactg cagcagacgg agctgtactg   2160

ccgggcccgg gggctgccct tcccccgggt ggaacccagc cctcaggacc agcaccagcc   2220

aagggaatgc cacctcttct cagaccccgc ctgccccgag gccccgatcc tgctgcactt   2280

cccgctggtc aatgcctcct tcaaggacca ctcagccccc ggtgtccagc gcagccccgc   2340

agagctccag ggtggccaag tggatctcac cggggccacc tgcccctaca ccctgtccaa   2400

catgacctac aaggaggaag acttcgagcg cctgctgcgg ctcagtgact acaacgtgca   2460

gaccagccag ggtgccatcc tgcaggccct gaggaccgcg ctgaagcacc ggactctaga   2520

ggcgaggcct ccaagggcac agacctgagg ttgctcagag gctgcaggac cctccagggc   2580

ctgcgggcat aacctgatct gtagctgggc tcagccacag gccttcctgg ttggagttct   2640

gggctctccc aggcctgggt ggcctctgta gctggtctca ctgcccagag ggaactgcac   2700

acacagactt ctctcttacg ttcatggctg gcttgagatg agttgaaaat aacttcgcca   2760

ggccagtgtg tagaacagct ggtccaacca gacagacttt cacaccacaa ttacttccat   2820

gcctgagcag gatagatttg aagtgcaagc cggaggcagc agatcaggag tagggacagg   2880

aaggacaggg gatgcctgac ctgacaggtg gcttcaggcc tcgggaatca caagacatcc   2940

tgaacacatt gcctcctcat cttcttcctg ctcctccacc tcctcctctc cttgtccttc   3000

tcctctttgt cctcctgctt tccgtatcca agtcttgtac ttgtttaaat ttattcctaa   3060

atattttatt ctttttgata agtggagtta ctttcttaat ttcatttaga ttattcattg   3120

ctattttata gaaatacaat ggatttttaa atgttgatct tgtattccgc aatcttgctg   3180

aagttgttta ccggctctaa tacttttgcg gatttcttag aattttctgt agacagatca   3240

tgccatctcc aaatagagat ggttttactt cttcctgtct gatctgaatg ccttttattt   3300

atttttccca attgccctga gcagtacaat gatgaacaca cgtttcaaga gcagacatct   3360

tgtcttgttc ctgactctga caagaaagca taagtctctc accatttagt gtgattttag   3420

ctgtgggttt ttcttggaca tccttatcag gttgagaaag ttctctttta tttctagttt   3480

attgagtgtt ttatgatgaa acggtgttag gttttgtcaa gtgatttttc tgtgtctatg   3540

ggcatgatca tgtggttttg tcgtgtattt tattaatgta                         3580


<210>  3174
<211>  818
<212>  PRT
<213>  Homo sapiens

<400>  3174


Met Glu Ser Leu Ser Pro Gly Gly Pro Pro Gly His Pro Tyr Gln Gly 
1               5                   10                  15      


Glu Ala Ser Thr Cys Trp Gln Leu Thr Val Arg Val Leu Glu Ala Arg 
            20                  25                  30          


Asn Leu Arg Trp Ala Asp Leu Leu Ser Glu Ala Asp Pro Tyr Val Ile 
        35                  40                  45              


Leu Gln Leu Ser Thr Ala Pro Gly Met Lys Phe Lys Thr Lys Thr Leu 
    50                  55                  60                  


Thr Asp Thr Ser His Pro Val Trp Asn Glu Ala Phe Arg Phe Leu Ile 
65                  70                  75                  80  


Gln Ser Gln Val Lys Asn Val Leu Glu Leu Ser Ile Tyr Asp Glu Asp 
                85                  90                  95      


Ser Val Thr Glu Asp Asp Ile Cys Phe Lys Val Leu Tyr Asp Ile Ser 
            100                 105                 110         


Glu Val Leu Pro Gly Lys Leu Leu Arg Lys Thr Phe Ser Gln Ser Pro 
        115                 120                 125             


Gln Gly Glu Glu Glu Leu Asp Val Glu Phe Leu Met Glu Glu Thr Ser 
    130                 135                 140                 


Asp Arg Pro Glu Asn Leu Ile Thr Asn Lys Val Ile Val Ala Arg Glu 
145                 150                 155                 160 


Leu Ser Cys Leu Asp Val His Leu Asp Ser Thr Gly Ser Thr Ala Val 
                165                 170                 175     


Val Ala Asp Gln Asp Lys Leu Glu Leu Glu Leu Val Leu Lys Gly Ser 
            180                 185                 190         


Tyr Glu Asp Thr Gln Thr Ser Phe Leu Gly Thr Ala Ser Ala Phe Arg 
        195                 200                 205             


Phe His Tyr Met Ala Ala Leu Glu Thr Glu Leu Ser Gly Arg Leu Arg 
    210                 215                 220                 


Ser Ser Arg Ser Asn Gly Trp Asn Gly Asp Asn Ser Ala Gly Tyr Leu 
225                 230                 235                 240 


Thr Val Pro Leu Arg Pro Leu Thr Ile Gly Lys Glu Val Thr Met Asp 
                245                 250                 255     


Val Pro Ala Pro Asn Ala Pro Gly Val Arg Leu Gln Leu Lys Ala Glu 
            260                 265                 270         


Gly Cys Pro Glu Glu Leu Ala Val His Leu Gly Phe Asn Leu Cys Ala 
        275                 280                 285             


Glu Glu Gln Ala Phe Leu Ser Arg Arg Lys Gln Val Val Ala Lys Ala 
    290                 295                 300                 


Leu Lys Gln Ala Leu Gln Leu Asp Arg Asp Leu Gln Glu Asp Glu Val 
305                 310                 315                 320 


Pro Val Val Gly Ile Met Ala Thr Gly Gly Gly Ala Arg Ala Met Thr 
                325                 330                 335     


Ser Leu Tyr Gly His Leu Leu Ala Leu Gln Lys Leu Gly Leu Leu Asp 
            340                 345                 350         


Cys Val Thr Tyr Phe Ser Gly Ile Ser Gly Ser Thr Trp Thr Met Ala 
        355                 360                 365             


His Leu Tyr Gly Asp Pro Glu Trp Ser Gln Arg Asp Leu Glu Gly Pro 
    370                 375                 380                 


Ile Arg Tyr Ala Arg Glu His Leu Ala Lys Ser Lys Leu Glu Val Phe 
385                 390                 395                 400 


Ser Pro Glu Arg Leu Ala Ser Tyr Arg Arg Glu Leu Glu Leu Arg Ala 
                405                 410                 415     


Glu Gln Gly His Pro Thr Thr Phe Val Asp Leu Trp Ala Leu Val Leu 
            420                 425                 430         


Glu Ser Met Leu His Gly Gln Val Met Asp Gln Lys Leu Ser Gly Gln 
        435                 440                 445             


Arg Ala Ala Leu Glu Arg Gly Gln Asn Pro Leu Pro Leu Tyr Leu Ser 
    450                 455                 460                 


Leu Asn Val Lys Glu Asn Asn Leu Glu Thr Leu Asp Phe Lys Glu Trp 
465                 470                 475                 480 


Val Glu Phe Ser Pro Tyr Glu Val Gly Phe Leu Lys Tyr Gly Ala Phe 
                485                 490                 495     


Val Pro Pro Glu Leu Phe Gly Ser Glu Phe Phe Met Gly Arg Leu Met 
            500                 505                 510         


Arg Arg Ile Pro Glu Pro Arg Ile Cys Phe Leu Glu Ala Ile Trp Ser 
        515                 520                 525             


Asn Ile Phe Ser Leu Asn Leu Leu Asp Ala Trp Tyr Asp Leu Thr Ser 
    530                 535                 540                 


Ser Gly Glu Ser Trp Lys Gln His Ile Lys Asp Lys Thr Arg Ser Leu 
545                 550                 555                 560 


Glu Lys Glu Pro Leu Thr Thr Ser Gly Thr Ser Ser Arg Leu Glu Ala 
                565                 570                 575     


Ser Trp Leu Gln Pro Gly Thr Ala Leu Ala Gln Ala Phe Lys Gly Phe 
            580                 585                 590         


Leu Thr Gly Arg Pro Leu His Gln Arg Ser Pro Asn Phe Leu Gln Gly 
        595                 600                 605             


Leu Gln Leu His Gln Asp Tyr Cys Ser His Lys Asp Phe Ser Thr Trp 
    610                 615                 620                 


Ala Asp Tyr Gln Leu Asp Ser Met Pro Ser Gln Leu Thr Pro Lys Glu 
625                 630                 635                 640 


Pro Arg Leu Cys Leu Val Asp Ala Ala Tyr Phe Ile Asn Thr Ser Ser 
                645                 650                 655     


Pro Ser Met Phe Arg Pro Gly Arg Arg Leu Asp Leu Ile Leu Ser Phe 
            660                 665                 670         


Asp Tyr Ser Leu Ser Ala Pro Phe Glu Ala Leu Gln Gln Thr Glu Leu 
        675                 680                 685             


Tyr Cys Arg Ala Arg Gly Leu Pro Phe Pro Arg Val Glu Pro Ser Pro 
    690                 695                 700                 


Gln Asp Gln His Gln Pro Arg Glu Cys His Leu Phe Ser Asp Pro Ala 
705                 710                 715                 720 


Cys Pro Glu Ala Pro Ile Leu Leu His Phe Pro Leu Val Asn Ala Ser 
                725                 730                 735     


Phe Lys Asp His Ser Ala Pro Gly Val Gln Arg Ser Pro Ala Glu Leu 
            740                 745                 750         


Gln Gly Gly Gln Val Asp Leu Thr Gly Ala Thr Cys Pro Tyr Thr Leu 
        755                 760                 765             


Ser Asn Met Thr Tyr Lys Glu Glu Asp Phe Glu Arg Leu Leu Arg Leu 
    770                 775                 780                 


Ser Asp Tyr Asn Val Gln Thr Ser Gln Gly Ala Ile Leu Gln Ala Leu 
785                 790                 795                 800 


Arg Thr Ala Leu Lys His Arg Thr Leu Glu Ala Arg Pro Pro Arg Ala 
                805                 810                 815     


Gln Thr 
        

<210>  3175
<211>  571
<212>  DNA
<213>  Homo sapiens

<400>  3175
cgggagtttg gcaaagccag gggagctgga ggggaggtgt ggagccaggg ccctcctggc     60

tgctgcggaa tatcaggttc agccgcggca gaggatcggc aatgggatga agggcctctg    120

cagccaatcc catcctgagc ccacacaact ccttgtgtgt gtggtggatt tgggacagtg    180

ggtctcagag ggttgaggtt aaggggacct cagcttaccc tgcagaggcc cctgcccatg    240

atgtggtctt ccccaggccc gagagctgtc atgcctggat gtgcatctgg acagcacagg    300

gagcaccgct gtggttgcag atcaggacaa gctggagctg gagctggtgc tgaaggggtc    360

ctatgaggac acacagacat ccttcctggg cacagcctct gccttccgct tccactacat    420

ggcagcccta gagacagagc tgagcgggcg cctgaggagc tccagaagca atggctggaa    480

tggggacaac tcagctgggt acctcactgt gcccctgagg cccttgacca ttgggaagga    540

ggtgactatg gatgttcctg ctccaaatgt a                                   571


<210>  3176
<211>  50
<212>  PRT
<213>  Homo sapiens

<400>  3176


Met Ala Ala Leu Glu Thr Glu Leu Ser Gly Arg Leu Arg Ser Ser Arg 
1               5                   10                  15      


Ser Asn Gly Trp Asn Gly Asp Asn Ser Ala Gly Tyr Leu Thr Val Pro 
            20                  25                  30          


Leu Arg Pro Leu Thr Ile Gly Lys Glu Val Thr Met Asp Val Pro Ala 
        35                  40                  45              


Pro Asn 
    50  

<210>  3177
<211>  1017
<212>  DNA
<213>  Homo sapiens

<400>  3177
gcggaggcta gaggcgggct gggaaggtgg aggggcgggc cggggcgggg ccaggccggc     60

tagaggggcg ggtctagcgg cggcccccgg cgaagttcac tgcgcttgcg ctgacagacg    120

caagatggcg gacagtgcgg aactaaagca aatggttatg agccttagag tttctgaact    180

ccaagtactg ttgggctacg ccgggagaaa caagcacgga cgcaaacacg aacttctcac    240

aaaagccctg catttgctaa aggctggctg tagtcctgct gtgcaaatga aaattaagga    300

actctatagg cggcggttcc cacagaaaat catgacgcct gcagacttgt ccatccccaa    360

cgtacattca agtcctatgc cagcaacttt gtctccatct accattccac aactcactta    420

cgatggtcac cctgcatcat cgccattact ccctgtttct cttctgggac ctaaacatga    480

actggaactc ccacatctta catcagctct tcacccagtc catccggata taaaacttca    540

aaaattacca ttttatgatt tactggatga actgataaaa cccaccagtc tagcatcaga    600

caacagtcag cgctttcgag aaacctgttt tgcatttgcc ttgacaccac aacaagtgca    660

gcaaatcagt agttccatgg atatttctgg gaccaaatgt gacttcacag tacaggtcca    720

gttaaggttt tgtttatcag aaaccagttg tccacaagaa gatcacttcc cacccaatct    780

ttgtgtgaaa gtgaatacaa aaccttgcag ccttccaggt taccttccac ctacaaaaaa    840

tggcgtggaa ccaaagcgac ccagccgacc aattaatatc acctcacttg tccgactgtc    900

cacaacagta ccaaacacga ttgttgtttc ttggactgca gaaattggaa gaaactattc    960

catggcagta tatcttgtaa aacagttgtc ctcaacagtt cttcttcaga ggttacg      1017


<210>  3178
<211>  296
<212>  PRT
<213>  Homo sapiens

<400>  3178


Met Ala Asp Ser Ala Glu Leu Lys Gln Met Val Met Ser Leu Arg Val 
1               5                   10                  15      


Ser Glu Leu Gln Val Leu Leu Gly Tyr Ala Gly Arg Asn Lys His Gly 
            20                  25                  30          


Arg Lys His Glu Leu Leu Thr Lys Ala Leu His Leu Leu Lys Ala Gly 
        35                  40                  45              


Cys Ser Pro Ala Val Gln Met Lys Ile Lys Glu Leu Tyr Arg Arg Arg 
    50                  55                  60                  


Phe Pro Gln Lys Ile Met Thr Pro Ala Asp Leu Ser Ile Pro Asn Val 
65                  70                  75                  80  


His Ser Ser Pro Met Pro Ala Thr Leu Ser Pro Ser Thr Ile Pro Gln 
                85                  90                  95      


Leu Thr Tyr Asp Gly His Pro Ala Ser Ser Pro Leu Leu Pro Val Ser 
            100                 105                 110         


Leu Leu Gly Pro Lys His Glu Leu Glu Leu Pro His Leu Thr Ser Ala 
        115                 120                 125             


Leu His Pro Val His Pro Asp Ile Lys Leu Gln Lys Leu Pro Phe Tyr 
    130                 135                 140                 


Asp Leu Leu Asp Glu Leu Ile Lys Pro Thr Ser Leu Ala Ser Asp Asn 
145                 150                 155                 160 


Ser Gln Arg Phe Arg Glu Thr Cys Phe Ala Phe Ala Leu Thr Pro Gln 
                165                 170                 175     


Gln Val Gln Gln Ile Ser Ser Ser Met Asp Ile Ser Gly Thr Lys Cys 
            180                 185                 190         


Asp Phe Thr Val Gln Val Gln Leu Arg Phe Cys Leu Ser Glu Thr Ser 
        195                 200                 205             


Cys Pro Gln Glu Asp His Phe Pro Pro Asn Leu Cys Val Lys Val Asn 
    210                 215                 220                 


Thr Lys Pro Cys Ser Leu Pro Gly Tyr Leu Pro Pro Thr Lys Asn Gly 
225                 230                 235                 240 


Val Glu Pro Lys Arg Pro Ser Arg Pro Ile Asn Ile Thr Ser Leu Val 
                245                 250                 255     


Arg Leu Ser Thr Thr Val Pro Asn Thr Ile Val Val Ser Trp Thr Ala 
            260                 265                 270         


Glu Ile Gly Arg Asn Tyr Ser Met Ala Val Tyr Leu Val Lys Gln Leu 
        275                 280                 285             


Ser Ser Thr Val Leu Leu Gln Arg 
    290                 295     

<210>  3179
<211>  5707
<212>  DNA
<213>  Homo sapiens

<400>  3179
gcggaggcta gaggcgggct gggaaggtgg aggggcgggc cggggcgggg ccaggccggc     60

tagaggggcg ggtctagcgg cggcccccgg cgaagttcac tgcgcttgcg ctgacagacg    120

caagatggcg gacagtgcgg aactaaagca aatggttatg agccttagag tttctgaact    180

ccaagtactg ttgggctacg ccgggagaaa caagcacgga cgcaaacacg aacttctcac    240

aaaagccctg catttgctaa aggctggctg tagtcctgct gtgcaaatga aaattaagga    300

actctatagg cggcggttcc cacagaaaat catgacgcct gcagacttgt ccatccccaa    360

cgtacattca agtcctatgc cagcaacttt gtctccatct accattccac aactcactta    420

cgatggtcac cctgcatcat cgccattact ccctgtttct cttctgggac ctaaacatga    480

actggaactc ccacatctta catcagctct tcacccagtc catccggata taaaacttca    540

aaaattacca ttttatgatt tactggatga actgataaaa cccaccagtc tagcatcaga    600

caacagtcag cgctttcgag aaacctgttt tgcatttgcc ttgacaccac aacaagtgca    660

gcaaatcagt agttccatgg atatttctgg gaccaaatgt gacttcacag tacaggtcca    720

gttaaggttt tgtttatcag aaaccagttg tccacaagaa gatcacttcc cacccaatct    780

ttgtgtgaaa gtgaatacaa aaccttgcag ccttccaggt taccttccac ctacaaaaaa    840

tggcgtggaa ccaaagcgac ccagccgacc aattaatatc acctcacttg tccgactgtc    900

cacaacagta ccaaacacga ttgttgtttc ttggactgca gaaattggaa gaaactattc    960

catggcagta tatcttgtaa aacagttgtc ctcaacagtt cttcttcaga ggttacgagc   1020

aaagggaata aggaatccgg atcattctag agctttaatt aaagagaagt tgactgcgga   1080

tccagacagt gaaatagcta caaccagcct aagggtttct ctactatgtc cacttggtaa   1140

aatgcggctg acaattccgt gtcgggccct tacatgttct catctacaat gttttgacgc   1200

aactctttac attcagatga atgagaaaaa accaacctgg gtttgtcctg tctgtgataa   1260

gaaggctcca tatgaacacc ttattattga tggcttgttt atggaaatcc taaagtactg   1320

tacagactgt gatgaaatac aatttaagga ggatggcact tgggcaccga tgagatcaaa   1380

aaaggaagta caggaagttt ctgcctctta caatggagtc gatggatgct tgagctccac   1440

attggagcat caggtagcgt ctcaccacca gtcctcaaat aaaaacaaga aagtagaagt   1500

gattgaccta accatagaca gttcatctga tgaagaggaa gaagagccat ctgccaagag   1560

gacctgtcct tccctatctc ccacatcacc actaaataat aaaggcattt taagtcttcc   1620

acatcaagca tctccagtat cccgcacccc aagccttcct gctgtagaca caagctacat   1680

taatacctcc ctcatccaag actataggca tcctttccac atgacaccca tgccttacga   1740

cttacaagga ttagatttct ttcctttctt atcaggagac aatcagcatt acaacacctc   1800

cttgcttgcc gctgcagcag cagcagtttc agatgatcaa gacctcctac actcgtctcg   1860

gtttttcccg tatacctcct cacagatgtt tcttgatcag ttaagtgcag gaggcagtac   1920

ttctctgcca accaccaatg gaagcagtag tggcagtaac agcagcctgg tttcttccaa   1980

cagcctaagg gaaagccata gccacaccgt cacaaacagg agcagcacgg acacggcatc   2040

catctttggc atcataccag acattatttc attggactga ttcccaggcc ctgctgctcc   2100

catccccacc ccagatcgaa tgaacttggc agaaagaaga gaactttgtg ctctgtttta   2160

ccttactctg tttagaaaag tatacaagcg tgtttttttt ccttttttta gggaaaaaat   2220

taaaagaaat gtacagagaa caaaactata ttttcagttt tacttttgta tataaatcta   2280

agactgcctg tgtgataaaa cacttgttta aaaaaaaaaa ggaaagaaaa gaaaaaagaa   2340

aaacaagcac ccacaaacca ccttcagttc atttttttct ggattctgaa gatttttcat   2400

tatttgtcct atggttttgg ttttatttga cttcgatggc attattttat ttgcaataac   2460

agaaaaggaa ttgcatgtat gaagttttca atcgtgggct tttctttgtt gtggggaggg   2520

ggtcggggga tagtttgatt tccattttct gaaaacgaca gacttggatt ctgtttgtgt   2580

gtgcatattt tatccagcct taagttataa agctcatctg tcccgctgca ttccctgtgt   2640

attttcagga catggctcgt gggtgtgtgt gttcattgtg tgcgtctgta tgtatttttc   2700

tgtcatcact gttccctctc ctcccgagtg tgcattcagt taatataatc agttgcttgc   2760

ttctttcaaa gtgctttgaa ggtcttgaac tcacgtgtga gcatctttat caactatccc   2820

aattgcatgt tctccatcac atattctctt atttgctctg taccccctga gaatatgttt   2880

tagagatatt ggaataaagc tgtctgggta aggagtaggc ttagccgacc tatgaataat   2940

acactttagt ctagttcttt attctaaatc tggattgcca gtattgtgta tttaaaccaa   3000

gtctgtgaat acctgctttt tttggccaca gagtaacaag ttttcatgta agatcttcat   3060

accaaagtag gaagtaaaaa tagcttagaa agctctgtca ggtgttttgt gcagctgaca   3120

gaggtaatgt tacatcacct aaaaaagaaa gatacacggt cagttatcct aaaaataaat   3180

tgtttggaaa gtacaatgca ccacattttt gtagaagtct actatttgat aaacagttga   3240

aattcaagat gtgtttgacc cttagtcatt tttactcttt ggttctgagt atacctattt   3300

tcttagcgta tctgccttgt ttatcttttt cttcaccttt taacaagtat gacataggaa   3360

agtcattttt ttttagaatt catggatcag tctgatctac tcttattcat aatggaacat   3420

gtaaatatac tgaaaactgt ttttcaggag agaaatatga gttggaggga aggaaaagtg   3480

gttctactaa tgttccaaaa tcctcatcag agaaggtatg atgttctcag gtgtggaaaa   3540

tattttttag ttgattgaga atgcaggttt aacagaagag ataaggggca taatgactgc   3600

tggttttcca gactggattt tcctaccgca actattaatg ttctcagagt tgatgaggac   3660

cacctttgtg tatacacttg tagttttaaa ccttgcattg gtaacaaaat gatcaacttt   3720

aatccaggta gaattcaaga tggctgtact tcagttgtat gataaaatta atggttctca   3780

tgacttgtgt ggcatctaaa aataatgttt ttatagcatc tctctgccac taaattgttg   3840

acttgaattt tgggaaaaaa aaaagttggt gttgatatgt atatgtgtgt gtgtatatat   3900

gtatttataa acaagtgtgt ttgagtaaca agtgagtttc atagtcttcc cctacgcatg   3960

tgtattccac acacaaatgg ctgagttata gtcataaaac aatttgcaat aaaaaaaaaa   4020

ccaaaacaga ttgtcagtta accaggaaac agttaatgtt ttttaatgaa tctggcatta   4080

tagtgagcaa atgtcgtatt aatttaggct aatttctaat actaccataa tttgtgtcta   4140

aatttctgtt ggggtagaaa ttactaaaat tgtggggagt tttttctgat ttttacattg   4200

ctttaggaaa catttttact aattcagctg tcttaggtaa aatgaatagt tttcttcctg   4260

tttttttatg tgtcattgtt agtggtctca gaattctgat cagtaacttt gtgtatgatg   4320

ctgaattaca aaccgtttga atgatccagt tgaaaacgta tccctctact ttcttcagtt   4380

gtagaaaagg ttaatttccc tcagtgtccc acattatacc aacctaagag aagaacaggt   4440

aatagggaga aataaacata cggtggtttc agtggttttg gtcatgtgtc cacaggagaa   4500

actaaccatt cagttgtctt aattttagtt cgttctaccc tgtgaggagt ttgtttccat   4560

cagttgttga ctttccaaaa tgttgcatta agtaatagtt gtcactctgt tggtctcatg   4620

gtcaatatca atcagacttt catgatctct actaattatt agtagagtcc tgtactatgt   4680

ctgtaactac taagtttaaa gaaaagcaca tagtcacttc atctcttttt ttcttagcct   4740

acgctcactc cccaacccat cccaacattg acatgctatc tgtggacaaa tagcagttct   4800

cagaatctag tcaagttgcc atcatccccc ttgccttggc cgttcatagt aggtatgcat   4860

atgtttgttt ctgtacagta ctgtgtgtgt gtgtgtgtat atatatatac atctgtatgc   4920

acacatcttt gataaaatag ctatttgact agcagggtta aagtggcttt taattacttc   4980

gtgagtgtta ttggatacat cttaaaaaaa aaaaatctga accagaacca tgccatactt   5040

ggttgactat tttgagcatt aaaattgctt tactaattat ttagacatga tcacaattct   5100

gtatctttac tgaggaaaga ttcacgtaag ctctgaaaaa tcggattctt tggcagattt   5160

tcctttgagt caagtgtctg aaatggagtg aaaatatatc ctaactaaat taatgtggaa   5220

agagcatttt tttagacaat ttcaatttta aacacataaa actttcaaga tcttcaggac   5280

tttttaaagc acatttgaaa ttattttagt aagaattttg ttttatcaat agatgttgaa   5340

ttctgttttt taattaaata caaagcttag atttcagaaa gagagggaaa atagctggtg   5400

gtcccagagt gtgctgctgt taattgttta acaaagggga aaatgtacat aaacagataa   5460

agttaccata aattccatga acttaaatct gtgattcatt gccttaaaac tttctctctt   5520

agaatttcca taccgcatgc caaaccagta aaatggcttt taaaaatgta tagtagacaa   5580

tgtcagtttg tataaaagta ccaagtgaaa atatttatta catgcattgg aaaaaaattg   5640

tttacctatt gaatgttacc tgtttatgta gagctcttta gatgtaataa aagaaaagcc   5700

ttcagtt                                                             5707


<210>  3180
<211>  651
<212>  PRT
<213>  Homo sapiens

<400>  3180


Met Ala Asp Ser Ala Glu Leu Lys Gln Met Val Met Ser Leu Arg Val 
1               5                   10                  15      


Ser Glu Leu Gln Val Leu Leu Gly Tyr Ala Gly Arg Asn Lys His Gly 
            20                  25                  30          


Arg Lys His Glu Leu Leu Thr Lys Ala Leu His Leu Leu Lys Ala Gly 
        35                  40                  45              


Cys Ser Pro Ala Val Gln Met Lys Ile Lys Glu Leu Tyr Arg Arg Arg 
    50                  55                  60                  


Phe Pro Gln Lys Ile Met Thr Pro Ala Asp Leu Ser Ile Pro Asn Val 
65                  70                  75                  80  


His Ser Ser Pro Met Pro Ala Thr Leu Ser Pro Ser Thr Ile Pro Gln 
                85                  90                  95      


Leu Thr Tyr Asp Gly His Pro Ala Ser Ser Pro Leu Leu Pro Val Ser 
            100                 105                 110         


Leu Leu Gly Pro Lys His Glu Leu Glu Leu Pro His Leu Thr Ser Ala 
        115                 120                 125             


Leu His Pro Val His Pro Asp Ile Lys Leu Gln Lys Leu Pro Phe Tyr 
    130                 135                 140                 


Asp Leu Leu Asp Glu Leu Ile Lys Pro Thr Ser Leu Ala Ser Asp Asn 
145                 150                 155                 160 


Ser Gln Arg Phe Arg Glu Thr Cys Phe Ala Phe Ala Leu Thr Pro Gln 
                165                 170                 175     


Gln Val Gln Gln Ile Ser Ser Ser Met Asp Ile Ser Gly Thr Lys Cys 
            180                 185                 190         


Asp Phe Thr Val Gln Val Gln Leu Arg Phe Cys Leu Ser Glu Thr Ser 
        195                 200                 205             


Cys Pro Gln Glu Asp His Phe Pro Pro Asn Leu Cys Val Lys Val Asn 
    210                 215                 220                 


Thr Lys Pro Cys Ser Leu Pro Gly Tyr Leu Pro Pro Thr Lys Asn Gly 
225                 230                 235                 240 


Val Glu Pro Lys Arg Pro Ser Arg Pro Ile Asn Ile Thr Ser Leu Val 
                245                 250                 255     


Arg Leu Ser Thr Thr Val Pro Asn Thr Ile Val Val Ser Trp Thr Ala 
            260                 265                 270         


Glu Ile Gly Arg Asn Tyr Ser Met Ala Val Tyr Leu Val Lys Gln Leu 
        275                 280                 285             


Ser Ser Thr Val Leu Leu Gln Arg Leu Arg Ala Lys Gly Ile Arg Asn 
    290                 295                 300                 


Pro Asp His Ser Arg Ala Leu Ile Lys Glu Lys Leu Thr Ala Asp Pro 
305                 310                 315                 320 


Asp Ser Glu Ile Ala Thr Thr Ser Leu Arg Val Ser Leu Leu Cys Pro 
                325                 330                 335     


Leu Gly Lys Met Arg Leu Thr Ile Pro Cys Arg Ala Leu Thr Cys Ser 
            340                 345                 350         


His Leu Gln Cys Phe Asp Ala Thr Leu Tyr Ile Gln Met Asn Glu Lys 
        355                 360                 365             


Lys Pro Thr Trp Val Cys Pro Val Cys Asp Lys Lys Ala Pro Tyr Glu 
    370                 375                 380                 


His Leu Ile Ile Asp Gly Leu Phe Met Glu Ile Leu Lys Tyr Cys Thr 
385                 390                 395                 400 


Asp Cys Asp Glu Ile Gln Phe Lys Glu Asp Gly Thr Trp Ala Pro Met 
                405                 410                 415     


Arg Ser Lys Lys Glu Val Gln Glu Val Ser Ala Ser Tyr Asn Gly Val 
            420                 425                 430         


Asp Gly Cys Leu Ser Ser Thr Leu Glu His Gln Val Ala Ser His His 
        435                 440                 445             


Gln Ser Ser Asn Lys Asn Lys Lys Val Glu Val Ile Asp Leu Thr Ile 
    450                 455                 460                 


Asp Ser Ser Ser Asp Glu Glu Glu Glu Glu Pro Ser Ala Lys Arg Thr 
465                 470                 475                 480 


Cys Pro Ser Leu Ser Pro Thr Ser Pro Leu Asn Asn Lys Gly Ile Leu 
                485                 490                 495     


Ser Leu Pro His Gln Ala Ser Pro Val Ser Arg Thr Pro Ser Leu Pro 
            500                 505                 510         


Ala Val Asp Thr Ser Tyr Ile Asn Thr Ser Leu Ile Gln Asp Tyr Arg 
        515                 520                 525             


His Pro Phe His Met Thr Pro Met Pro Tyr Asp Leu Gln Gly Leu Asp 
    530                 535                 540                 


Phe Phe Pro Phe Leu Ser Gly Asp Asn Gln His Tyr Asn Thr Ser Leu 
545                 550                 555                 560 


Leu Ala Ala Ala Ala Ala Ala Val Ser Asp Asp Gln Asp Leu Leu His 
                565                 570                 575     


Ser Ser Arg Phe Phe Pro Tyr Thr Ser Ser Gln Met Phe Leu Asp Gln 
            580                 585                 590         


Leu Ser Ala Gly Gly Ser Thr Ser Leu Pro Thr Thr Asn Gly Ser Ser 
        595                 600                 605             


Ser Gly Ser Asn Ser Ser Leu Val Ser Ser Asn Ser Leu Arg Glu Ser 
    610                 615                 620                 


His Ser His Thr Val Thr Asn Arg Ser Ser Thr Asp Thr Ala Ser Ile 
625                 630                 635                 640 


Phe Gly Ile Ile Pro Asp Ile Ile Ser Leu Asp 
                645                 650     

<210>  3181
<211>  6450
<212>  DNA
<213>  Homo sapiens

<400>  3181
gcggaggcta gaggcgggct gggaaggtgg aggggcgggc cggggcgggg ccaggccggc     60

tagaggggcg ggtctagcgg cggcccccgg cgaagttcac tgcgcttgcg ctgacagacg    120

caagatggcg gacagtgcgg aactaaagca aatggttatg agccttagag tttctgaact    180

ccaagtactg ttgggctacg ccgggagaaa caagcacgga cgcaaacacg aacttctcac    240

aaaagccctg catttgctaa aggctggctg tagtcctgct gtgcaaatga aaattaagga    300

actctatagg cggcggttcc cacagaaaat catgacgcct gcagacttgt ccatccccaa    360

cgtacattca agtcctatgc cagcaacttt gtctccatct accattccac aactcactta    420

cgatggtcac cctgcatcat cgccattact ccctgtttct cttctgggac ctaaacatga    480

actggaactc ccacatctta catcagctct tcacccagtc catccggata taaaacttca    540

aaaattacca ttttatgatt tactggatga actgataaaa cccaccagtc tagcatcaga    600

caacagtcag cgctttcgag aaacctgttt tgcatttgcc ttgacaccac aacaagtgca    660

gcaaatcagt agttccatgg atatttctgg gaccaaatgt gacttcacag tacaggtcca    720

gttaaggttt tgtttatcag aaaccagttg tccacaagaa gatcacttcc cacccaatct    780

ttgtgtgaaa gtgaatacaa aaccttgcag ccttccaggt taccttccac ctacaaaaaa    840

tggcgtggaa ccaaagcgac ccagccgacc aattaatatc acctcacttg tccgactgtc    900

cacaacagta ccaaacacga ttgttgtttc ttggactgca gaaattggaa gaaactattc    960

catggcagta tatcttgtaa aacagttgtc ctcaacagtt cttcttcaga ggttacgagc   1020

aaagggaata aggaatccgg atcattctag agctttaatt aaagagaagt tgactgcgga   1080

tccagacagt gaaatagcta caaccagcct aagggtttct ctactatgtc cacttggtaa   1140

aatgcggctg acaattccgt gtcgggccct tacatgttct catctacaat gttttgacgc   1200

aactctttac attcagatga atgagaaaaa accaacctgg gtttgtcctg tctgtgataa   1260

gaaggctcca tatgaacacc ttattattga tggcttgttt atggaaatcc taaagtactg   1320

tacagactgt gatgaaatac aatttaagga ggatggcact tgggcaccga tgagatcaaa   1380

aaaggaagta caggaagttt ctgcctctta caatggagtc gatggatgct tgagctccac   1440

attggagcat caggtagcgt ctcaccacca gtcctcaaat aaaaacaaga aagtagaagt   1500

gattgaccta accatagaca gttcatctga tgaagaggaa gaagagccat ctgccaagag   1560

gacctgtcct tccctatctc ccacatcacc actaaataat aaaggcattt taagtcttcc   1620

acatcaagca tctccagtat cccgcacccc aagccttcct gctgtagaca caagctacat   1680

taatacctcc ctcatccaag actataggca tcctttccac atgacaccca tgccttacga   1740

cttacaagga ttagatttct ttcctttctt atcaggagac aatcagcatt acaacacctc   1800

cttgcttgcc gctgcagcag cagcagtttc agatgatcaa gacctcctac actcgtctcg   1860

gtttttcccg tatacctcct cacagatgtt tcttgatcag ttaagtgcag gaggcagtac   1920

ttctctgcca accaccaatg gaagcagtag tggcagtaac agcagcctgg tttcttccaa   1980

cagcctaagg gaaagccata gccacaccgt cacaaacagg agcagcacgg acacggcatc   2040

catctttggc atcataccag acattatttc attggactga ttcccaggcc ctgctgctcc   2100

catccccacc ccagatcgaa tgaacttggc agaaagaaga gaactttgtg ctctgtttta   2160

ccttactctg tttagaaaag tatacaagcg tgtttttttt ccttttttta gggaaaaaat   2220

taaaagaaat gtacagagaa caaaactata ttttcagttt tacttttgta tataaatcta   2280

agactgcctg tgtgataaaa cacttgttta aaaaaaaaaa ggaaagaaaa gaaaaaagaa   2340

aaacaagcac ccacaaacca ccttcagttc atttttttct ggattctgaa gatttttcat   2400

tatttgtcct atggttttgg ttttatttga cttcgatggc attattttat ttgcaataac   2460

agaaaaggaa ttgcatgtat gaagttttca atcgtgggct tttctttgtt gtggggaggg   2520

ggtcggggga tagtttgatt tccattttct gaaaacgaca gacttggatt ctgtttgtgt   2580

gtgcatattt tatccagcct taagttataa agctcatctg tcccgctgca ttccctgtgt   2640

attttcagga catggctcgt gggtgtgtgt gttcattgtg tgcgtctgta tgtatttttc   2700

tgtcatcact gttccctctc ctcccgagtg tgcattcagt taatataatc agttgcttgc   2760

ttctttcaaa gtgctttgaa ggtcttgaac tcacgtgtga gcatctttat caactatccc   2820

aattgcatgt tctccatcac atattctctt atttgctctg taccccctga gaatatgttt   2880

tagagatatt ggaataaagc tgtctgggta aggagtaggc ttagccgacc tatgaataat   2940

acactttagt ctagttcttt attctaaatc tggattgcca gtattgtgta tttaaaccaa   3000

gtctgtgaat acctgctttt tttggccaca gagtaacaag ttttcatgta agatcttcat   3060

accaaagtag gaagtaaaaa tagcttagaa agctctgtca ggtgttttgt gcagctgaca   3120

gaggtaatgt tacatcacct aaaaaagaaa gatacacggt cagttatcct aaaaataaat   3180

tgtttggaaa gtacaatgca ccacattttt gtagaagtct actatttgat aaacagttga   3240

aattcaagat gtgtttgacc cttagtcatt tttactcttt ggttctgagt atacctattt   3300

tcttagcgta tctgccttgt ttatcttttt cttcaccttt taacaagtat gacataggaa   3360

agtcattttt ttttagaatt catggatcag tctgatctac tcttattcat aatggaacat   3420

gtaaatatac tgaaaactgt ttttcaggag agaaatatga gttggaggga aggaaaagtg   3480

gttctactaa tgttccaaaa tcctcatcag agaaggtatg atgttctcag gtgtggaaaa   3540

tattttttag ttgattgaga atgcaggttt aacagaagag ataaggggca taatgactgc   3600

tggttttcca gactggattt tcctaccgca actattaatg ttctcagagt tgatgaggac   3660

cacctttgtg tatacacttg tagttttaaa ccttgcattg gtaacaaaat gatcaacttt   3720

aatccaggta gaattcaaga tggctgtact tcagttgtat gataaaatta atggttctca   3780

tgacttgtgt ggcatctaaa aataatgttt ttatagcatc tctctgccac taaattgttg   3840

acttgaattt tgggaaaaaa aaaagttggt gttgatatgt atatgtgtgt gtgtatatat   3900

gtatttataa acaagtgtgt ttgagtaaca agtgagtttc atagtcttcc cctacgcatg   3960

tgtattccac acacaaatgg ctgagttata gtcataaaac aatttgcaat aaaaaaaaaa   4020

ccaaaacaga ttgtcagtta accaggaaac agttaatgtt ttttaatgaa tctggcatta   4080

tagtgagcaa atgtcgtatt aatttaggct aatttctaat actaccataa tttgtgtcta   4140

aatttctgtt ggggtagaaa ttactaaaat tgtggggagt tttttctgat ttttacattg   4200

ctttaggaaa catttttact aattcagctg tcttaggtaa aatgaatagt tttcttcctg   4260

tttttttatg tgtcattgtt agtggtctca gaattctgat cagtaacttt gtgtatgatg   4320

ctgaattaca aaccgtttga atgatccagt tgaaaacgta tccctctact ttcttcagtt   4380

gtagaaaagg ttaatttccc tcagtgtccc acattatacc aacctaagag aagaacaggt   4440

aatagggaga aataaacata cggtggtttc agtggttttg gtcatgtgtc cacaggagaa   4500

actaaccatt cagttgtctt aattttagtt cgttctaccc tgtgaggagt ttgtttccat   4560

cagttgttga ctttccaaaa tgttgcatta agtaatagtt gtcactctgt tggtctcatg   4620

gtcaatatca atcagacttt catgatctct actaattatt agtagagtcc tgtactatgt   4680

ctgtaactac taagtttaaa gaaaagcaca tagtcacttc atctcttttt ttcttagcct   4740

acgctcactc cccaacccat cccaacattg acatgctatc tgtggacaaa tagcagttct   4800

cagaatctag tcaagttgcc atcatccccc ttgccttggc cgttcatagt aggtatgcat   4860

atgtttgttt ctgtacagta ctgtgtgtgt gtgtgtgtat atatatatac atctgtatgc   4920

acacatcttt gataaaatag ctatttgact agcagggtta aagtggcttt taattacttc   4980

gtgagtgtta ttggatacat cttaaaaaaa aaaaatctga accagaacca tgccatactt   5040

ggttgactat tttgagcatt aaaattgctt tactaattat ttagacatga tcacaattct   5100

gtatctttac tgaggaaaga ttcacgtaag ctctgaaaaa tcggattctt tggcagattt   5160

tcctttgagt caagtgtctg aaatggagtg aaaatatatc ctaactaaat taatgtggaa   5220

agagcatttt tttagacaat ttcaatttta aacacataaa actttcaaga tcttcaggac   5280

tttttaaagc acatttgaaa ttattttagt aagaattttg ttttatcaat agatgttgaa   5340

ttctgttttt taattaaata caaagcttag atttcagaaa gagagggaaa atagctggtg   5400

gtcccagagt gtgctgctgt taattgttta acaaagggga aaatgtacat aaacagataa   5460

agttaccata aattccatga acttaaatct gtgattcatt gccttaaaac tttctctctt   5520

agaatttcca taccgcatgc caaaccagta aaatggcttt taaaaatgta tagtagacaa   5580

tgtcagtttg tataaaagta ccaagtgaaa atatttatta catgcattgg aaaaaaattg   5640

tttacctatt gaatgttacc tgtttatgta gagctcttta gatgtaataa aagaaaagcc   5700

ttcagttaat ttgtcttctg taaaataaca ctgctggatg ttcaagggga caatccctat   5760

gagacaagtg ataatggttt gtgcttccaa agcacctttc atccagagat ttcaaagcat   5820

gacaagtaac taactaattt tcttgcagca tgctttgagg taagtaatga atatagccat   5880

catttccctt tcttgttgaa atatggctaa ctctttaata aatcacagca tctgtttagt   5940

atctgcagtt tgaatgctaa gagcaccgtg gccttcttgt aaacaacact aggtgctaga   6000

gaaaccagct ggaatttcag gaatgagctt gaaaccagga ccaggagtaa ggtaacagcc   6060

cttcctcggg tagaggtttg aatcaaacac ttaataggat cttagactct ggaccactga   6120

atcccttaat gagcagggag tccgtgaaga ggagccccag gttctaatga ccattccaca   6180

ccaactgtgt gtttttggca agttatattt cagattcctg ttaggcaaat gagattcata   6240

aaacttgctt taaaaccata ctgggactat tcagtgataa atatagacat agaaaagctt   6300

tgacggaaag taccctcatt tattatatcc agaacttgct cttcctgtgc catctaaatc   6360

attggtatct atctcccatc taatctttgg tattccaggt tggctgtgca ggatttactt   6420

cctaatgtcc atgactggag ctcaaaagaa                                    6450


<210>  3182
<211>  651
<212>  PRT
<213>  Homo sapiens

<400>  3182


Met Ala Asp Ser Ala Glu Leu Lys Gln Met Val Met Ser Leu Arg Val 
1               5                   10                  15      


Ser Glu Leu Gln Val Leu Leu Gly Tyr Ala Gly Arg Asn Lys His Gly 
            20                  25                  30          


Arg Lys His Glu Leu Leu Thr Lys Ala Leu His Leu Leu Lys Ala Gly 
        35                  40                  45              


Cys Ser Pro Ala Val Gln Met Lys Ile Lys Glu Leu Tyr Arg Arg Arg 
    50                  55                  60                  


Phe Pro Gln Lys Ile Met Thr Pro Ala Asp Leu Ser Ile Pro Asn Val 
65                  70                  75                  80  


His Ser Ser Pro Met Pro Ala Thr Leu Ser Pro Ser Thr Ile Pro Gln 
                85                  90                  95      


Leu Thr Tyr Asp Gly His Pro Ala Ser Ser Pro Leu Leu Pro Val Ser 
            100                 105                 110         


Leu Leu Gly Pro Lys His Glu Leu Glu Leu Pro His Leu Thr Ser Ala 
        115                 120                 125             


Leu His Pro Val His Pro Asp Ile Lys Leu Gln Lys Leu Pro Phe Tyr 
    130                 135                 140                 


Asp Leu Leu Asp Glu Leu Ile Lys Pro Thr Ser Leu Ala Ser Asp Asn 
145                 150                 155                 160 


Ser Gln Arg Phe Arg Glu Thr Cys Phe Ala Phe Ala Leu Thr Pro Gln 
                165                 170                 175     


Gln Val Gln Gln Ile Ser Ser Ser Met Asp Ile Ser Gly Thr Lys Cys 
            180                 185                 190         


Asp Phe Thr Val Gln Val Gln Leu Arg Phe Cys Leu Ser Glu Thr Ser 
        195                 200                 205             


Cys Pro Gln Glu Asp His Phe Pro Pro Asn Leu Cys Val Lys Val Asn 
    210                 215                 220                 


Thr Lys Pro Cys Ser Leu Pro Gly Tyr Leu Pro Pro Thr Lys Asn Gly 
225                 230                 235                 240 


Val Glu Pro Lys Arg Pro Ser Arg Pro Ile Asn Ile Thr Ser Leu Val 
                245                 250                 255     


Arg Leu Ser Thr Thr Val Pro Asn Thr Ile Val Val Ser Trp Thr Ala 
            260                 265                 270         


Glu Ile Gly Arg Asn Tyr Ser Met Ala Val Tyr Leu Val Lys Gln Leu 
        275                 280                 285             


Ser Ser Thr Val Leu Leu Gln Arg Leu Arg Ala Lys Gly Ile Arg Asn 
    290                 295                 300                 


Pro Asp His Ser Arg Ala Leu Ile Lys Glu Lys Leu Thr Ala Asp Pro 
305                 310                 315                 320 


Asp Ser Glu Ile Ala Thr Thr Ser Leu Arg Val Ser Leu Leu Cys Pro 
                325                 330                 335     


Leu Gly Lys Met Arg Leu Thr Ile Pro Cys Arg Ala Leu Thr Cys Ser 
            340                 345                 350         


His Leu Gln Cys Phe Asp Ala Thr Leu Tyr Ile Gln Met Asn Glu Lys 
        355                 360                 365             


Lys Pro Thr Trp Val Cys Pro Val Cys Asp Lys Lys Ala Pro Tyr Glu 
    370                 375                 380                 


His Leu Ile Ile Asp Gly Leu Phe Met Glu Ile Leu Lys Tyr Cys Thr 
385                 390                 395                 400 


Asp Cys Asp Glu Ile Gln Phe Lys Glu Asp Gly Thr Trp Ala Pro Met 
                405                 410                 415     


Arg Ser Lys Lys Glu Val Gln Glu Val Ser Ala Ser Tyr Asn Gly Val 
            420                 425                 430         


Asp Gly Cys Leu Ser Ser Thr Leu Glu His Gln Val Ala Ser His His 
        435                 440                 445             


Gln Ser Ser Asn Lys Asn Lys Lys Val Glu Val Ile Asp Leu Thr Ile 
    450                 455                 460                 


Asp Ser Ser Ser Asp Glu Glu Glu Glu Glu Pro Ser Ala Lys Arg Thr 
465                 470                 475                 480 


Cys Pro Ser Leu Ser Pro Thr Ser Pro Leu Asn Asn Lys Gly Ile Leu 
                485                 490                 495     


Ser Leu Pro His Gln Ala Ser Pro Val Ser Arg Thr Pro Ser Leu Pro 
            500                 505                 510         


Ala Val Asp Thr Ser Tyr Ile Asn Thr Ser Leu Ile Gln Asp Tyr Arg 
        515                 520                 525             


His Pro Phe His Met Thr Pro Met Pro Tyr Asp Leu Gln Gly Leu Asp 
    530                 535                 540                 


Phe Phe Pro Phe Leu Ser Gly Asp Asn Gln His Tyr Asn Thr Ser Leu 
545                 550                 555                 560 


Leu Ala Ala Ala Ala Ala Ala Val Ser Asp Asp Gln Asp Leu Leu His 
                565                 570                 575     


Ser Ser Arg Phe Phe Pro Tyr Thr Ser Ser Gln Met Phe Leu Asp Gln 
            580                 585                 590         


Leu Ser Ala Gly Gly Ser Thr Ser Leu Pro Thr Thr Asn Gly Ser Ser 
        595                 600                 605             


Ser Gly Ser Asn Ser Ser Leu Val Ser Ser Asn Ser Leu Arg Glu Ser 
    610                 615                 620                 


His Ser His Thr Val Thr Asn Arg Ser Ser Thr Asp Thr Ala Ser Ile 
625                 630                 635                 640 


Phe Gly Ile Ile Pro Asp Ile Ile Ser Leu Asp 
                645                 650     

<210>  3183
<211>  6577
<212>  DNA
<213>  Homo sapiens

<400>  3183
ggcggacagt gcggaactaa aggtaaagcg cagctcgaat tcacttctaa tattcggccg     60

cggagacggc gccgctgctg ccagggggga tgggtccgac cctggggggc ctctcgggcc    120

tgactccacc cgggcctgga gttgtaggga gagaggcgcg cccggtctca gcagaggggg    180

cccgcctgcg gcgggccgcg ggccccgggt gcctcggggg cgctgacggg tcgtccccgg    240

cgtgttattg ttgtgggcgc ctctggcggg ggtggcgggg gaagagatag ggagtccgga    300

ggtaggggct gcagctgtct catgggctcg gctttttcac cttccagtta gcctccctgc    360

cccccatggg gagctggggc tgggggcagg gtgctctcgt aggggggatt gggaaagctc    420

cccgtggccg cttcctcttc ctcctttgca gtcccgggct cctgtcaggc gctcttctca    480

gacccccggg aacttggctt cggccgcccc gcccctccgt ggatcccagt agcccccgcc    540

ccggactcgg ctttccccgg ctgctcgctt gtcaggaagc gcctggggtg ccccgcttgt    600

gggaagcgcg atcccggggc gatagggtgg ggatctgggg gagaagctct ggtaaagttt    660

agcgagcccc gggccggcgt tggggttcgg ctgagaggta gtgagcggga cgttactctt    720

tctctctgat tccgggcagc cgaggggaga aaccccctcg aagagtgtgt ctttggaagc    780

agtgttggga gggggggatg cagctacctc tctcccttct tttgccttag ctggtgtgga    840

gggtgagagg agcctttggg ggtctctgca cacaccatga tggcgatgct gtagctgatg    900

gagaacaacc aaatgccaga tttgattctg tagagttttt cctgtggaat atcctcaccg    960

aaagagcttt tctcctaata acttcacaat gtttacactc caagattcgt atgttaagca   1020

aatggttatg agccttagag tttctgaact ccaagtactg ttgggctacg ccgggagaaa   1080

caagcacgga cgcaaacacg aacttctcac aaaagccctg catttgctaa aggctggctg   1140

tagtcctgct gtgcaaatga aaattaagga actctatagg cggcggttcc cacagaaaat   1200

catgacgcct gcagacttgt ccatccccaa cgtacattca agtcctatgc cagcaacttt   1260

gtctccatct accattccac aactcactta cgatggtcac cctgcatcat cgccattact   1320

ccctgtttct cttctgggac ctaaacatga actggaactc ccacatctta catcagctct   1380

tcacccagtc catccggata taaaacttca aaaattacca ttttatgatt tactggatga   1440

actgataaaa cccaccagtc tagcatcaga caacagtcag cgctttcgag aaacctgttt   1500

tgcatttgcc ttgacaccac aacaagtgca gcaaatcagt agttccatgg atatttctgg   1560

gaccaaatgt gacttcacag tacaggtcca gttaaggttt tgtttatcag aaaccagttg   1620

tccacaagaa gatcacttcc cacccaatct ttgtgtgaaa gtgaatacaa aaccttgcag   1680

ccttccaggt taccttccac ctacaaaaaa tggcgtggaa ccaaagcgac ccagccgacc   1740

aattaatatc acctcacttg tccgactgtc cacaacagta ccaaacacga ttgttgtttc   1800

ttggactgca gaaattggaa gaaactattc catggcagta tatcttgtaa aacagttgtc   1860

ctcaacagtt cttcttcaga ggttacgagc aaagggaata aggaatccgg atcattctag   1920

agctttaatt aaagagaagt tgactgcgga tccagacagt gaaatagcta caaccagcct   1980

aagggtttct ctactatgtc cacttggtaa aatgcggctg acaattccgt gtcgggccct   2040

tacatgttct catctacaat gttttgacgc aactctttac attcagatga atgagaaaaa   2100

accaacctgg gtttgtcctg tctgtgataa gaaggctcca tatgaacacc ttattattga   2160

tggcttgttt atggaaatcc taaagtactg tacagactgt gatgaaatac aatttaagga   2220

ggatggcact tgggcaccga tgagatcaaa aaaggaagta caggaagttt ctgcctctta   2280

caatggagtc gatggatgct tgagctccac attggagcat caggtagcgt ctcaccacca   2340

gtcctcaaat aaaaacaaga aagtagaagt gattgaccta accatagaca gttcatctga   2400

tgaagaggaa gaagagccat ctgccaagag gacctgtcct tccctatctc ccacatcacc   2460

actaaataat aaaggcattt taagtcttcc acatcaagca tctccagtat cccgcacccc   2520

aagccttcct gctgtagaca caagctacat taatacctcc ctcatccaag actataggca   2580

tcctttccac atgacaccca tgccttacga cttacaagga ttagatttct ttcctttctt   2640

atcaggagac aatcagcatt acaacacctc cttgcttgcc gctgcagcag cagcagtttc   2700

agatgatcaa gacctcctac actcgtctcg gtttttcccg tatacctcct cacagatgtt   2760

tcttgatcag ttaagtgcag gaggcagtac ttctctgcca accaccaatg gaagcagtag   2820

tggcagtaac agcagcctgg tttcttccaa cagcctaagg gaaagccata gccacaccgt   2880

cacaaacagg agcagcacgg acacggcatc catctttggc atcataccag acattatttc   2940

attggactga ttcccaggcc ctgctgctcc catccccacc ccagatcgaa tgaacttggc   3000

agaaagaaga gaactttgtg ctctgtttta ccttactctg tttagaaaag tatacaagcg   3060

tgtttttttt ccttttttta gggaaaaaat taaaagaaat gtacagagaa caaaactata   3120

ttttcagttt tacttttgta tataaatcta agactgcctg tgtgataaaa cacttgttta   3180

aaaaaaaaaa ggaaagaaaa gaaaaaagaa aaacaagcac ccacaaacca ccttcagttc   3240

atttttttct ggattctgaa gatttttcat tatttgtcct atggttttgg ttttatttga   3300

cttcgatggc attattttat ttgcaataac agaaaaggaa ttgcatgtat gaagttttca   3360

atcgtgggct tttctttgtt gtggggaggg ggtcggggga tagtttgatt tccattttct   3420

gaaaacgaca gacttggatt ctgtttgtgt gtgcatattt tatccagcct taagttataa   3480

agctcatctg tcccgctgca ttccctgtgt attttcagga catggctcgt gggtgtgtgt   3540

gttcattgtg tgcgtctgta tgtatttttc tgtcatcact gttccctctc ctcccgagtg   3600

tgcattcagt taatataatc agttgcttgc ttctttcaaa gtgctttgaa ggtcttgaac   3660

tcacgtgtga gcatctttat caactatccc aattgcatgt tctccatcac atattctctt   3720

atttgctctg taccccctga gaatatgttt tagagatatt ggaataaagc tgtctgggta   3780

aggagtaggc ttagccgacc tatgaataat acactttagt ctagttcttt attctaaatc   3840

tggattgcca gtattgtgta tttaaaccaa gtctgtgaat acctgctttt tttggccaca   3900

gagtaacaag ttttcatgta agatcttcat accaaagtag gaagtaaaaa tagcttagaa   3960

agctctgtca ggtgttttgt gcagctgaca gaggtaatgt tacatcacct aaaaaagaaa   4020

gatacacggt cagttatcct aaaaataaat tgtttggaaa gtacaatgca ccacattttt   4080

gtagaagtct actatttgat aaacagttga aattcaagat gtgtttgacc cttagtcatt   4140

tttactcttt ggttctgagt atacctattt tcttagcgta tctgccttgt ttatcttttt   4200

cttcaccttt taacaagtat gacataggaa agtcattttt ttttagaatt catggatcag   4260

tctgatctac tcttattcat aatggaacat gtaaatatac tgaaaactgt ttttcaggag   4320

agaaatatga gttggaggga aggaaaagtg gttctactaa tgttccaaaa tcctcatcag   4380

agaaggtatg atgttctcag gtgtggaaaa tattttttag ttgattgaga atgcaggttt   4440

aacagaagag ataaggggca taatgactgc tggttttcca gactggattt tcctaccgca   4500

actattaatg ttctcagagt tgatgaggac cacctttgtg tatacacttg tagttttaaa   4560

ccttgcattg gtaacaaaat gatcaacttt aatccaggta gaattcaaga tggctgtact   4620

tcagttgtat gataaaatta atggttctca tgacttgtgt ggcatctaaa aataatgttt   4680

ttatagcatc tctctgccac taaattgttg acttgaattt tgggaaaaaa aaaagttggt   4740

gttgatatgt atatgtgtgt gtgtatatat gtatttataa acaagtgtgt ttgagtaaca   4800

agtgagtttc atagtcttcc cctacgcatg tgtattccac acacaaatgg ctgagttata   4860

gtcataaaac aatttgcaat aaaaaaaaaa ccaaaacaga ttgtcagtta accaggaaac   4920

agttaatgtt ttttaatgaa tctggcatta tagtgagcaa atgtcgtatt aatttaggct   4980

aatttctaat actaccataa tttgtgtcta aatttctgtt ggggtagaaa ttactaaaat   5040

tgtggggagt tttttctgat ttttacattg ctttaggaaa catttttact aattcagctg   5100

tcttaggtaa aatgaatagt tttcttcctg tttttttatg tgtcattgtt agtggtctca   5160

gaattctgat cagtaacttt gtgtatgatg ctgaattaca aaccgtttga atgatccagt   5220

tgaaaacgta tccctctact ttcttcagtt gtagaaaagg ttaatttccc tcagtgtccc   5280

acattatacc aacctaagag aagaacaggt aatagggaga aataaacata cggtggtttc   5340

agtggttttg gtcatgtgtc cacaggagaa actaaccatt cagttgtctt aattttagtt   5400

cgttctaccc tgtgaggagt ttgtttccat cagttgttga ctttccaaaa tgttgcatta   5460

agtaatagtt gtcactctgt tggtctcatg gtcaatatca atcagacttt catgatctct   5520

actaattatt agtagagtcc tgtactatgt ctgtaactac taagtttaaa gaaaagcaca   5580

tagtcacttc atctcttttt ttcttagcct acgctcactc cccaacccat cccaacattg   5640

acatgctatc tgtggacaaa tagcagttct cagaatctag tcaagttgcc atcatccccc   5700

ttgccttggc cgttcatagt aggtatgcat atgtttgttt ctgtacagta ctgtgtgtgt   5760

gtgtgtgtat atatatatac atctgtatgc acacatcttt gataaaatag ctatttgact   5820

agcagggtta aagtggcttt taattacttc gtgagtgtta ttggatacat cttaaaaaaa   5880

aaaaatctga accagaacca tgccatactt ggttgactat tttgagcatt aaaattgctt   5940

tactaattat ttagacatga tcacaattct gtatctttac tgaggaaaga ttcacgtaag   6000

ctctgaaaaa tcggattctt tggcagattt tcctttgagt caagtgtctg aaatggagtg   6060

aaaatatatc ctaactaaat taatgtggaa agagcatttt tttagacaat ttcaatttta   6120

aacacataaa actttcaaga tcttcaggac tttttaaagc acatttgaaa ttattttagt   6180

aagaattttg ttttatcaat agatgttgaa ttctgttttt taattaaata caaagcttag   6240

atttcagaaa gagagggaaa atagctggtg gtcccagagt gtgctgctgt taattgttta   6300

acaaagggga aaatgtacat aaacagataa agttaccata aattccatga acttaaatct   6360

gtgattcatt gccttaaaac tttctctctt agaatttcca taccgcatgc caaaccagta   6420

aaatggcttt taaaaatgta tagtagacaa tgtcagtttg tataaaagta ccaagtgaaa   6480

atatttatta catgcattgg aaaaaaattg tttacctatt gaatgttacc tgtttatgta   6540

gagctcttta gatgtaataa aagaaaagcc ttcagtt                            6577


<210>  3184
<211>  653
<212>  PRT
<213>  Homo sapiens

<400>  3184


Met Phe Thr Leu Gln Asp Ser Tyr Val Lys Gln Met Val Met Ser Leu 
1               5                   10                  15      


Arg Val Ser Glu Leu Gln Val Leu Leu Gly Tyr Ala Gly Arg Asn Lys 
            20                  25                  30          


His Gly Arg Lys His Glu Leu Leu Thr Lys Ala Leu His Leu Leu Lys 
        35                  40                  45              


Ala Gly Cys Ser Pro Ala Val Gln Met Lys Ile Lys Glu Leu Tyr Arg 
    50                  55                  60                  


Arg Arg Phe Pro Gln Lys Ile Met Thr Pro Ala Asp Leu Ser Ile Pro 
65                  70                  75                  80  


Asn Val His Ser Ser Pro Met Pro Ala Thr Leu Ser Pro Ser Thr Ile 
                85                  90                  95      


Pro Gln Leu Thr Tyr Asp Gly His Pro Ala Ser Ser Pro Leu Leu Pro 
            100                 105                 110         


Val Ser Leu Leu Gly Pro Lys His Glu Leu Glu Leu Pro His Leu Thr 
        115                 120                 125             


Ser Ala Leu His Pro Val His Pro Asp Ile Lys Leu Gln Lys Leu Pro 
    130                 135                 140                 


Phe Tyr Asp Leu Leu Asp Glu Leu Ile Lys Pro Thr Ser Leu Ala Ser 
145                 150                 155                 160 


Asp Asn Ser Gln Arg Phe Arg Glu Thr Cys Phe Ala Phe Ala Leu Thr 
                165                 170                 175     


Pro Gln Gln Val Gln Gln Ile Ser Ser Ser Met Asp Ile Ser Gly Thr 
            180                 185                 190         


Lys Cys Asp Phe Thr Val Gln Val Gln Leu Arg Phe Cys Leu Ser Glu 
        195                 200                 205             


Thr Ser Cys Pro Gln Glu Asp His Phe Pro Pro Asn Leu Cys Val Lys 
    210                 215                 220                 


Val Asn Thr Lys Pro Cys Ser Leu Pro Gly Tyr Leu Pro Pro Thr Lys 
225                 230                 235                 240 


Asn Gly Val Glu Pro Lys Arg Pro Ser Arg Pro Ile Asn Ile Thr Ser 
                245                 250                 255     


Leu Val Arg Leu Ser Thr Thr Val Pro Asn Thr Ile Val Val Ser Trp 
            260                 265                 270         


Thr Ala Glu Ile Gly Arg Asn Tyr Ser Met Ala Val Tyr Leu Val Lys 
        275                 280                 285             


Gln Leu Ser Ser Thr Val Leu Leu Gln Arg Leu Arg Ala Lys Gly Ile 
    290                 295                 300                 


Arg Asn Pro Asp His Ser Arg Ala Leu Ile Lys Glu Lys Leu Thr Ala 
305                 310                 315                 320 


Asp Pro Asp Ser Glu Ile Ala Thr Thr Ser Leu Arg Val Ser Leu Leu 
                325                 330                 335     


Cys Pro Leu Gly Lys Met Arg Leu Thr Ile Pro Cys Arg Ala Leu Thr 
            340                 345                 350         


Cys Ser His Leu Gln Cys Phe Asp Ala Thr Leu Tyr Ile Gln Met Asn 
        355                 360                 365             


Glu Lys Lys Pro Thr Trp Val Cys Pro Val Cys Asp Lys Lys Ala Pro 
    370                 375                 380                 


Tyr Glu His Leu Ile Ile Asp Gly Leu Phe Met Glu Ile Leu Lys Tyr 
385                 390                 395                 400 


Cys Thr Asp Cys Asp Glu Ile Gln Phe Lys Glu Asp Gly Thr Trp Ala 
                405                 410                 415     


Pro Met Arg Ser Lys Lys Glu Val Gln Glu Val Ser Ala Ser Tyr Asn 
            420                 425                 430         


Gly Val Asp Gly Cys Leu Ser Ser Thr Leu Glu His Gln Val Ala Ser 
        435                 440                 445             


His His Gln Ser Ser Asn Lys Asn Lys Lys Val Glu Val Ile Asp Leu 
    450                 455                 460                 


Thr Ile Asp Ser Ser Ser Asp Glu Glu Glu Glu Glu Pro Ser Ala Lys 
465                 470                 475                 480 


Arg Thr Cys Pro Ser Leu Ser Pro Thr Ser Pro Leu Asn Asn Lys Gly 
                485                 490                 495     


Ile Leu Ser Leu Pro His Gln Ala Ser Pro Val Ser Arg Thr Pro Ser 
            500                 505                 510         


Leu Pro Ala Val Asp Thr Ser Tyr Ile Asn Thr Ser Leu Ile Gln Asp 
        515                 520                 525             


Tyr Arg His Pro Phe His Met Thr Pro Met Pro Tyr Asp Leu Gln Gly 
    530                 535                 540                 


Leu Asp Phe Phe Pro Phe Leu Ser Gly Asp Asn Gln His Tyr Asn Thr 
545                 550                 555                 560 


Ser Leu Leu Ala Ala Ala Ala Ala Ala Val Ser Asp Asp Gln Asp Leu 
                565                 570                 575     


Leu His Ser Ser Arg Phe Phe Pro Tyr Thr Ser Ser Gln Met Phe Leu 
            580                 585                 590         


Asp Gln Leu Ser Ala Gly Gly Ser Thr Ser Leu Pro Thr Thr Asn Gly 
        595                 600                 605             


Ser Ser Ser Gly Ser Asn Ser Ser Leu Val Ser Ser Asn Ser Leu Arg 
    610                 615                 620                 


Glu Ser His Ser His Thr Val Thr Asn Arg Ser Ser Thr Asp Thr Ala 
625                 630                 635                 640 


Ser Ile Phe Gly Ile Ile Pro Asp Ile Ile Ser Leu Asp 
                645                 650             

<210>  3185
<211>  7320
<212>  DNA
<213>  Homo sapiens

<400>  3185
ggcggacagt gcggaactaa aggtaaagcg cagctcgaat tcacttctaa tattcggccg     60

cggagacggc gccgctgctg ccagggggga tgggtccgac cctggggggc ctctcgggcc    120

tgactccacc cgggcctgga gttgtaggga gagaggcgcg cccggtctca gcagaggggg    180

cccgcctgcg gcgggccgcg ggccccgggt gcctcggggg cgctgacggg tcgtccccgg    240

cgtgttattg ttgtgggcgc ctctggcggg ggtggcgggg gaagagatag ggagtccgga    300

ggtaggggct gcagctgtct catgggctcg gctttttcac cttccagtta gcctccctgc    360

cccccatggg gagctggggc tgggggcagg gtgctctcgt aggggggatt gggaaagctc    420

cccgtggccg cttcctcttc ctcctttgca gtcccgggct cctgtcaggc gctcttctca    480

gacccccggg aacttggctt cggccgcccc gcccctccgt ggatcccagt agcccccgcc    540

ccggactcgg ctttccccgg ctgctcgctt gtcaggaagc gcctggggtg ccccgcttgt    600

gggaagcgcg atcccggggc gatagggtgg ggatctgggg gagaagctct ggtaaagttt    660

agcgagcccc gggccggcgt tggggttcgg ctgagaggta gtgagcggga cgttactctt    720

tctctctgat tccgggcagc cgaggggaga aaccccctcg aagagtgtgt ctttggaagc    780

agtgttggga gggggggatg cagctacctc tctcccttct tttgccttag ctggtgtgga    840

gggtgagagg agcctttggg ggtctctgca cacaccatga tggcgatgct gtagctgatg    900

gagaacaacc aaatgccaga tttgattctg tagagttttt cctgtggaat atcctcaccg    960

aaagagcttt tctcctaata acttcacaat gtttacactc caagattcgt atgttaagca   1020

aatggttatg agccttagag tttctgaact ccaagtactg ttgggctacg ccgggagaaa   1080

caagcacgga cgcaaacacg aacttctcac aaaagccctg catttgctaa aggctggctg   1140

tagtcctgct gtgcaaatga aaattaagga actctatagg cggcggttcc cacagaaaat   1200

catgacgcct gcagacttgt ccatccccaa cgtacattca agtcctatgc cagcaacttt   1260

gtctccatct accattccac aactcactta cgatggtcac cctgcatcat cgccattact   1320

ccctgtttct cttctgggac ctaaacatga actggaactc ccacatctta catcagctct   1380

tcacccagtc catccggata taaaacttca aaaattacca ttttatgatt tactggatga   1440

actgataaaa cccaccagtc tagcatcaga caacagtcag cgctttcgag aaacctgttt   1500

tgcatttgcc ttgacaccac aacaagtgca gcaaatcagt agttccatgg atatttctgg   1560

gaccaaatgt gacttcacag tacaggtcca gttaaggttt tgtttatcag aaaccagttg   1620

tccacaagaa gatcacttcc cacccaatct ttgtgtgaaa gtgaatacaa aaccttgcag   1680

ccttccaggt taccttccac ctacaaaaaa tggcgtggaa ccaaagcgac ccagccgacc   1740

aattaatatc acctcacttg tccgactgtc cacaacagta ccaaacacga ttgttgtttc   1800

ttggactgca gaaattggaa gaaactattc catggcagta tatcttgtaa aacagttgtc   1860

ctcaacagtt cttcttcaga ggttacgagc aaagggaata aggaatccgg atcattctag   1920

agctttaatt aaagagaagt tgactgcgga tccagacagt gaaatagcta caaccagcct   1980

aagggtttct ctactatgtc cacttggtaa aatgcggctg acaattccgt gtcgggccct   2040

tacatgttct catctacaat gttttgacgc aactctttac attcagatga atgagaaaaa   2100

accaacctgg gtttgtcctg tctgtgataa gaaggctcca tatgaacacc ttattattga   2160

tggcttgttt atggaaatcc taaagtactg tacagactgt gatgaaatac aatttaagga   2220

ggatggcact tgggcaccga tgagatcaaa aaaggaagta caggaagttt ctgcctctta   2280

caatggagtc gatggatgct tgagctccac attggagcat caggtagcgt ctcaccacca   2340

gtcctcaaat aaaaacaaga aagtagaagt gattgaccta accatagaca gttcatctga   2400

tgaagaggaa gaagagccat ctgccaagag gacctgtcct tccctatctc ccacatcacc   2460

actaaataat aaaggcattt taagtcttcc acatcaagca tctccagtat cccgcacccc   2520

aagccttcct gctgtagaca caagctacat taatacctcc ctcatccaag actataggca   2580

tcctttccac atgacaccca tgccttacga cttacaagga ttagatttct ttcctttctt   2640

atcaggagac aatcagcatt acaacacctc cttgcttgcc gctgcagcag cagcagtttc   2700

agatgatcaa gacctcctac actcgtctcg gtttttcccg tatacctcct cacagatgtt   2760

tcttgatcag ttaagtgcag gaggcagtac ttctctgcca accaccaatg gaagcagtag   2820

tggcagtaac agcagcctgg tttcttccaa cagcctaagg gaaagccata gccacaccgt   2880

cacaaacagg agcagcacgg acacggcatc catctttggc atcataccag acattatttc   2940

attggactga ttcccaggcc ctgctgctcc catccccacc ccagatcgaa tgaacttggc   3000

agaaagaaga gaactttgtg ctctgtttta ccttactctg tttagaaaag tatacaagcg   3060

tgtttttttt ccttttttta gggaaaaaat taaaagaaat gtacagagaa caaaactata   3120

ttttcagttt tacttttgta tataaatcta agactgcctg tgtgataaaa cacttgttta   3180

aaaaaaaaaa ggaaagaaaa gaaaaaagaa aaacaagcac ccacaaacca ccttcagttc   3240

atttttttct ggattctgaa gatttttcat tatttgtcct atggttttgg ttttatttga   3300

cttcgatggc attattttat ttgcaataac agaaaaggaa ttgcatgtat gaagttttca   3360

atcgtgggct tttctttgtt gtggggaggg ggtcggggga tagtttgatt tccattttct   3420

gaaaacgaca gacttggatt ctgtttgtgt gtgcatattt tatccagcct taagttataa   3480

agctcatctg tcccgctgca ttccctgtgt attttcagga catggctcgt gggtgtgtgt   3540

gttcattgtg tgcgtctgta tgtatttttc tgtcatcact gttccctctc ctcccgagtg   3600

tgcattcagt taatataatc agttgcttgc ttctttcaaa gtgctttgaa ggtcttgaac   3660

tcacgtgtga gcatctttat caactatccc aattgcatgt tctccatcac atattctctt   3720

atttgctctg taccccctga gaatatgttt tagagatatt ggaataaagc tgtctgggta   3780

aggagtaggc ttagccgacc tatgaataat acactttagt ctagttcttt attctaaatc   3840

tggattgcca gtattgtgta tttaaaccaa gtctgtgaat acctgctttt tttggccaca   3900

gagtaacaag ttttcatgta agatcttcat accaaagtag gaagtaaaaa tagcttagaa   3960

agctctgtca ggtgttttgt gcagctgaca gaggtaatgt tacatcacct aaaaaagaaa   4020

gatacacggt cagttatcct aaaaataaat tgtttggaaa gtacaatgca ccacattttt   4080

gtagaagtct actatttgat aaacagttga aattcaagat gtgtttgacc cttagtcatt   4140

tttactcttt ggttctgagt atacctattt tcttagcgta tctgccttgt ttatcttttt   4200

cttcaccttt taacaagtat gacataggaa agtcattttt ttttagaatt catggatcag   4260

tctgatctac tcttattcat aatggaacat gtaaatatac tgaaaactgt ttttcaggag   4320

agaaatatga gttggaggga aggaaaagtg gttctactaa tgttccaaaa tcctcatcag   4380

agaaggtatg atgttctcag gtgtggaaaa tattttttag ttgattgaga atgcaggttt   4440

aacagaagag ataaggggca taatgactgc tggttttcca gactggattt tcctaccgca   4500

actattaatg ttctcagagt tgatgaggac cacctttgtg tatacacttg tagttttaaa   4560

ccttgcattg gtaacaaaat gatcaacttt aatccaggta gaattcaaga tggctgtact   4620

tcagttgtat gataaaatta atggttctca tgacttgtgt ggcatctaaa aataatgttt   4680

ttatagcatc tctctgccac taaattgttg acttgaattt tgggaaaaaa aaaagttggt   4740

gttgatatgt atatgtgtgt gtgtatatat gtatttataa acaagtgtgt ttgagtaaca   4800

agtgagtttc atagtcttcc cctacgcatg tgtattccac acacaaatgg ctgagttata   4860

gtcataaaac aatttgcaat aaaaaaaaaa ccaaaacaga ttgtcagtta accaggaaac   4920

agttaatgtt ttttaatgaa tctggcatta tagtgagcaa atgtcgtatt aatttaggct   4980

aatttctaat actaccataa tttgtgtcta aatttctgtt ggggtagaaa ttactaaaat   5040

tgtggggagt tttttctgat ttttacattg ctttaggaaa catttttact aattcagctg   5100

tcttaggtaa aatgaatagt tttcttcctg tttttttatg tgtcattgtt agtggtctca   5160

gaattctgat cagtaacttt gtgtatgatg ctgaattaca aaccgtttga atgatccagt   5220

tgaaaacgta tccctctact ttcttcagtt gtagaaaagg ttaatttccc tcagtgtccc   5280

acattatacc aacctaagag aagaacaggt aatagggaga aataaacata cggtggtttc   5340

agtggttttg gtcatgtgtc cacaggagaa actaaccatt cagttgtctt aattttagtt   5400

cgttctaccc tgtgaggagt ttgtttccat cagttgttga ctttccaaaa tgttgcatta   5460

agtaatagtt gtcactctgt tggtctcatg gtcaatatca atcagacttt catgatctct   5520

actaattatt agtagagtcc tgtactatgt ctgtaactac taagtttaaa gaaaagcaca   5580

tagtcacttc atctcttttt ttcttagcct acgctcactc cccaacccat cccaacattg   5640

acatgctatc tgtggacaaa tagcagttct cagaatctag tcaagttgcc atcatccccc   5700

ttgccttggc cgttcatagt aggtatgcat atgtttgttt ctgtacagta ctgtgtgtgt   5760

gtgtgtgtat atatatatac atctgtatgc acacatcttt gataaaatag ctatttgact   5820

agcagggtta aagtggcttt taattacttc gtgagtgtta ttggatacat cttaaaaaaa   5880

aaaaatctga accagaacca tgccatactt ggttgactat tttgagcatt aaaattgctt   5940

tactaattat ttagacatga tcacaattct gtatctttac tgaggaaaga ttcacgtaag   6000

ctctgaaaaa tcggattctt tggcagattt tcctttgagt caagtgtctg aaatggagtg   6060

aaaatatatc ctaactaaat taatgtggaa agagcatttt tttagacaat ttcaatttta   6120

aacacataaa actttcaaga tcttcaggac tttttaaagc acatttgaaa ttattttagt   6180

aagaattttg ttttatcaat agatgttgaa ttctgttttt taattaaata caaagcttag   6240

atttcagaaa gagagggaaa atagctggtg gtcccagagt gtgctgctgt taattgttta   6300

acaaagggga aaatgtacat aaacagataa agttaccata aattccatga acttaaatct   6360

gtgattcatt gccttaaaac tttctctctt agaatttcca taccgcatgc caaaccagta   6420

aaatggcttt taaaaatgta tagtagacaa tgtcagtttg tataaaagta ccaagtgaaa   6480

atatttatta catgcattgg aaaaaaattg tttacctatt gaatgttacc tgtttatgta   6540

gagctcttta gatgtaataa aagaaaagcc ttcagttaat ttgtcttctg taaaataaca   6600

ctgctggatg ttcaagggga caatccctat gagacaagtg ataatggttt gtgcttccaa   6660

agcacctttc atccagagat ttcaaagcat gacaagtaac taactaattt tcttgcagca   6720

tgctttgagg taagtaatga atatagccat catttccctt tcttgttgaa atatggctaa   6780

ctctttaata aatcacagca tctgtttagt atctgcagtt tgaatgctaa gagcaccgtg   6840

gccttcttgt aaacaacact aggtgctaga gaaaccagct ggaatttcag gaatgagctt   6900

gaaaccagga ccaggagtaa ggtaacagcc cttcctcggg tagaggtttg aatcaaacac   6960

ttaataggat cttagactct ggaccactga atcccttaat gagcagggag tccgtgaaga   7020

ggagccccag gttctaatga ccattccaca ccaactgtgt gtttttggca agttatattt   7080

cagattcctg ttaggcaaat gagattcata aaacttgctt taaaaccata ctgggactat   7140

tcagtgataa atatagacat agaaaagctt tgacggaaag taccctcatt tattatatcc   7200

agaacttgct cttcctgtgc catctaaatc attggtatct atctcccatc taatctttgg   7260

tattccaggt tggctgtgca ggatttactt cctaatgtcc atgactggag ctcaaaagaa   7320


<210>  3186
<211>  653
<212>  PRT
<213>  Homo sapiens

<400>  3186


Met Phe Thr Leu Gln Asp Ser Tyr Val Lys Gln Met Val Met Ser Leu 
1               5                   10                  15      


Arg Val Ser Glu Leu Gln Val Leu Leu Gly Tyr Ala Gly Arg Asn Lys 
            20                  25                  30          


His Gly Arg Lys His Glu Leu Leu Thr Lys Ala Leu His Leu Leu Lys 
        35                  40                  45              


Ala Gly Cys Ser Pro Ala Val Gln Met Lys Ile Lys Glu Leu Tyr Arg 
    50                  55                  60                  


Arg Arg Phe Pro Gln Lys Ile Met Thr Pro Ala Asp Leu Ser Ile Pro 
65                  70                  75                  80  


Asn Val His Ser Ser Pro Met Pro Ala Thr Leu Ser Pro Ser Thr Ile 
                85                  90                  95      


Pro Gln Leu Thr Tyr Asp Gly His Pro Ala Ser Ser Pro Leu Leu Pro 
            100                 105                 110         


Val Ser Leu Leu Gly Pro Lys His Glu Leu Glu Leu Pro His Leu Thr 
        115                 120                 125             


Ser Ala Leu His Pro Val His Pro Asp Ile Lys Leu Gln Lys Leu Pro 
    130                 135                 140                 


Phe Tyr Asp Leu Leu Asp Glu Leu Ile Lys Pro Thr Ser Leu Ala Ser 
145                 150                 155                 160 


Asp Asn Ser Gln Arg Phe Arg Glu Thr Cys Phe Ala Phe Ala Leu Thr 
                165                 170                 175     


Pro Gln Gln Val Gln Gln Ile Ser Ser Ser Met Asp Ile Ser Gly Thr 
            180                 185                 190         


Lys Cys Asp Phe Thr Val Gln Val Gln Leu Arg Phe Cys Leu Ser Glu 
        195                 200                 205             


Thr Ser Cys Pro Gln Glu Asp His Phe Pro Pro Asn Leu Cys Val Lys 
    210                 215                 220                 


Val Asn Thr Lys Pro Cys Ser Leu Pro Gly Tyr Leu Pro Pro Thr Lys 
225                 230                 235                 240 


Asn Gly Val Glu Pro Lys Arg Pro Ser Arg Pro Ile Asn Ile Thr Ser 
                245                 250                 255     


Leu Val Arg Leu Ser Thr Thr Val Pro Asn Thr Ile Val Val Ser Trp 
            260                 265                 270         


Thr Ala Glu Ile Gly Arg Asn Tyr Ser Met Ala Val Tyr Leu Val Lys 
        275                 280                 285             


Gln Leu Ser Ser Thr Val Leu Leu Gln Arg Leu Arg Ala Lys Gly Ile 
    290                 295                 300                 


Arg Asn Pro Asp His Ser Arg Ala Leu Ile Lys Glu Lys Leu Thr Ala 
305                 310                 315                 320 


Asp Pro Asp Ser Glu Ile Ala Thr Thr Ser Leu Arg Val Ser Leu Leu 
                325                 330                 335     


Cys Pro Leu Gly Lys Met Arg Leu Thr Ile Pro Cys Arg Ala Leu Thr 
            340                 345                 350         


Cys Ser His Leu Gln Cys Phe Asp Ala Thr Leu Tyr Ile Gln Met Asn 
        355                 360                 365             


Glu Lys Lys Pro Thr Trp Val Cys Pro Val Cys Asp Lys Lys Ala Pro 
    370                 375                 380                 


Tyr Glu His Leu Ile Ile Asp Gly Leu Phe Met Glu Ile Leu Lys Tyr 
385                 390                 395                 400 


Cys Thr Asp Cys Asp Glu Ile Gln Phe Lys Glu Asp Gly Thr Trp Ala 
                405                 410                 415     


Pro Met Arg Ser Lys Lys Glu Val Gln Glu Val Ser Ala Ser Tyr Asn 
            420                 425                 430         


Gly Val Asp Gly Cys Leu Ser Ser Thr Leu Glu His Gln Val Ala Ser 
        435                 440                 445             


His His Gln Ser Ser Asn Lys Asn Lys Lys Val Glu Val Ile Asp Leu 
    450                 455                 460                 


Thr Ile Asp Ser Ser Ser Asp Glu Glu Glu Glu Glu Pro Ser Ala Lys 
465                 470                 475                 480 


Arg Thr Cys Pro Ser Leu Ser Pro Thr Ser Pro Leu Asn Asn Lys Gly 
                485                 490                 495     


Ile Leu Ser Leu Pro His Gln Ala Ser Pro Val Ser Arg Thr Pro Ser 
            500                 505                 510         


Leu Pro Ala Val Asp Thr Ser Tyr Ile Asn Thr Ser Leu Ile Gln Asp 
        515                 520                 525             


Tyr Arg His Pro Phe His Met Thr Pro Met Pro Tyr Asp Leu Gln Gly 
    530                 535                 540                 


Leu Asp Phe Phe Pro Phe Leu Ser Gly Asp Asn Gln His Tyr Asn Thr 
545                 550                 555                 560 


Ser Leu Leu Ala Ala Ala Ala Ala Ala Val Ser Asp Asp Gln Asp Leu 
                565                 570                 575     


Leu His Ser Ser Arg Phe Phe Pro Tyr Thr Ser Ser Gln Met Phe Leu 
            580                 585                 590         


Asp Gln Leu Ser Ala Gly Gly Ser Thr Ser Leu Pro Thr Thr Asn Gly 
        595                 600                 605             


Ser Ser Ser Gly Ser Asn Ser Ser Leu Val Ser Ser Asn Ser Leu Arg 
    610                 615                 620                 


Glu Ser His Ser His Thr Val Thr Asn Arg Ser Ser Thr Asp Thr Ala 
625                 630                 635                 640 


Ser Ile Phe Gly Ile Ile Pro Asp Ile Ile Ser Leu Asp 
                645                 650             

<210>  3187
<211>  4493
<212>  DNA
<213>  Homo sapiens

<400>  3187
aaaagcggcc tctcggctga gggccgggga gctagcgctc aagcagagcc cagcgcggtg     60

ctatcggaca gagcctggcg agcgcaagcg gcgcggggag ccagcggggc tgagcgcggc    120

cagggtctga acccagattt cccagactag ctaccactcc gcttgcccac gccccgggag    180

ctcgcggcgc ctggcggtca gcgaccagac gtccggggcc gctgcgctcc tggcccgcga    240

ggcgtgacac tgtctcggct acagacccag agggagcaca ctgccaggat gggagctgct    300

gggaggcagg acttcctctt caaggccatg ctgaccatca gctggctcac tctgacctgc    360

ttccctgggg ccacatccac agtggctgct gggtgccctg accagagccc tgagttgcaa    420

ccctggaacc ctggccatga ccaagaccac catgtgcata tcggccaggg caagacactg    480

ctgctcacct cttctgccac ggtctattcc atccacatct cagagggagg caagctggtc    540

attaaagacc acgacgagcc gattgttttg cgaacccggc acatcctgat tgacaacgga    600

ggagagctgc atgctgggag tgccctctgc cctttccagg gcaatttcac catcattttg    660

tatggaaggg ctgatgaagg tattcagccg gatccttact atggtctgaa gtacattggg    720

gttggtaaag gaggcgctct tgagttgcat ggacagaaaa agctctcctg gacatttctg    780

aacaagaccc ttcacccagg tggcatggca gaaggaggct atttttttga aaggagctgg    840

ggccaccgtg gagttattgt tcatgtcatc gaccccaaat caggcacagt catccattct    900

gaccggtttg acacctatag atccaagaaa gagagtgaac gtctggtcca gtatttgaac    960

gcggtgcccg atggcaggat cctttctgtt gcagtgaatg atgaaggttc tcgaaatctg   1020

gatgacatgg ccaggaaggc gatgaccaaa ttgggaagca aacacttcct gcaccttgga   1080

tttagacacc cttggagttt tctaactgtg aaaggaaatc catcatcttc agtggaagac   1140

catattgaat atcatggaca tcgaggctct gctgctgccc gggtattcaa attgttccag   1200

acagagcatg gcgaatattt caatgtttct ttgtccagtg agtgggttca agacgtggag   1260

tggacggagt ggttcgatca tgataaagta tctcagacta aaggtgggga gaaaatttca   1320

gacctctgga aagctcaccc aggaaaaata tgcaatcgtc ccattgatat acaggccact   1380

acaatggatg gagttaacct cagcaccgag gttgtctaca aaaaaggcca ggattatagg   1440

tttgcttgct acgaccgggg cagagcctgc cggagctacc gtgtacggtt cctctgtggg   1500

aagcctgtga ggcccaaact cacagtcacc attgacacca atgtgaacag caccattctg   1560

aacttggagg ataatgtaca gtcatggaaa cctggagata ccctggtcat tgccagtact   1620

gattactcca tgtaccaggc agaagagttc caggtgcttc cctgcagatc ctgcgccccc   1680

aaccaggtca aagtggcagg gaaaccaatg tacctgcaca tcggggagga gatagacggc   1740

gtggacatgc gggcggaggt tgggcttctg agccggaaca tcatagtgat gggggagatg   1800

gaggacaaat gctaccccta cagaaaccac atctgcaatt tctttgactt cgataccttt   1860

gggggccaca tcaagtttgc tctgggattt aaggcagcac acttggaggg cacggagctg   1920

aagcatatgg gacagcagct ggtgggtcag tacccgattc acttccacct ggccggtgat   1980

gtagacgaaa ggggaggtta tgacccaccc acatacatca gggacctctc catccatcat   2040

acattctctc gctgcgtcac agtccatggc tccaatggct tgttgatcaa ggacgttgtg   2100

ggctataact ctttgggcca ctgcttcttc acggaagatg ggccggagga acgcaacact   2160

tttgaccact gtcttggcct ccttgtcaag tctggaaccc tcctcccctc ggaccgtgac   2220

agcaagatgt gcaagatgat cacagaggac tcctacccgg ggtacatccc caagcccagg   2280

caagactgca atgctgtgtc caccttctgg atggccaatc ccaacaacaa cctcatcaac   2340

tgtgccgctg caggatctga ggaaactgga ttttggttta tttttcacca cgtaccaacg   2400

ggcccctccg tgggaatgta ctccccaggt tattcagagc acattccact gggaaaattc   2460

tataacaacc gagcacattc caactaccgg gctggcatga tcatagacaa cggagtcaaa   2520

accaccgagg cctctgccaa ggacaagcgg ccgttcctct caatcatctc tgccagatac   2580

agccctcacc aggacgccga cccgctgaag ccccgggagc cggccatcat cagacacttc   2640

attgcctaca agaaccagga ccacggggcc tggctgcgcg gcggggatgt gtggctggac   2700

agcagtgcca tttcagaggg gaggctcagg aaggcttctt gcttacagga atgaaggctg   2760

ggggcatttt gctgggggga gatgaggcag cctctggaat ggctcaggga ttcagccctc   2820

cctgccgctg cctgctgaag ctggtgacta cggggtcgcc ctttgctcac gtctctctgg   2880

cccactcatg atggagaagt gtggtcagag gggagcaatg ggctttgctg cttatgagca   2940

cagaggaatt cagtccccag gcagccctgc ctctgactcc aagagggtga agtccacaga   3000

agtgagctcc tgccttaggg cctcatttgc tcttcatcca gggaactgag cacagggggc   3060

ctccaggaga ccctagatgt gctcgtactc cctcggccca cacagctaag ggagggcctg   3120

gggagcccca ccctagccct tgctgccaca ccacattgcc tcaacaaccg gccccagagt   3180

gcccaggcac tcctgaggta gcttctggaa atggggacaa gtcccctcga aggaaaggaa   3240

atgactagag tagaatgaca gctagcagat ctcttccctc ctgctcccag cgcacacaaa   3300

cccgccctcc ccttggtgtt ggcggtccct gtggccttca ctttgttcac tacctgtcag   3360

cccagcctgg gtgcacagta gctgcaactc cccattggtg ctacctggct ctcctgtctc   3420

tgcagctcta caggtgaggc ccagcagagg gagtagggct cgccatgttt ctggtgagcc   3480

aatttggctg atcttgggtg tctgaacagc tattgggtcc accccagtcc ctttcagctg   3540

ctgcttaatg ccctgctctc tccctggccc accttataga gagcccaaag agctcctgta   3600

agagggagaa ctctatctgt ggtttataat cttgcacgag gcaccagagt ctccctgggt   3660

cttgtgatga actacattta tcccctttcc tgccccaacc acaaactctt tccttcaaag   3720

agggcctgcc tggctccctc cacccaactg cacccatgag actcggtcca agagtccatt   3780

ccccaggtgg gagccaactg tcagggaggt ctttcccacc aaacatcttt cagctgctgg   3840

gaggtgacca tagggctctg cttttaaaga tatggctgct tcaaaggcca gagtcacagg   3900

aaggacttct tccagggaga ttagtggtga tggagaggag agttaaaatg acctcatgtc   3960

cttcttgtcc acggttttgt tgagttttca ctcttctaat gcaagggtct cacactgtga   4020

accacttagg atgtgatcac tttcaggtgg ccaggaatgt tgaatgtctt tggctcagtt   4080

catttaaaaa agatatctat ttgaaagttc tcagagttgt acatatgttt cacagtacag   4140

gatctgtaca taaaagtttc tttcctaaac cattcaccaa gagccaatat ctaggcattt   4200

tcttggtagc acaaattttc ttattgctta gaaaattgtc ctccttgtta tttctgtttg   4260

taagacttaa gtgagttagg tctttaagga aagcaacgct cctctgaaat gcttgtcttt   4320

tttctgttgc cgaaatagct ggtccttttt cgggagttag atgtatagag tgtttgtatg   4380

taaacatttc ttgtaggcat caccatgaac aaagatatat tttctattta tttattatat   4440

gtgcacttca agaagtcact gtcagagaaa taaagaattg tcttaaatgt cat          4493


<210>  3188
<211>  821
<212>  PRT
<213>  Homo sapiens

<400>  3188


Met Gly Ala Ala Gly Arg Gln Asp Phe Leu Phe Lys Ala Met Leu Thr 
1               5                   10                  15      


Ile Ser Trp Leu Thr Leu Thr Cys Phe Pro Gly Ala Thr Ser Thr Val 
            20                  25                  30          


Ala Ala Gly Cys Pro Asp Gln Ser Pro Glu Leu Gln Pro Trp Asn Pro 
        35                  40                  45              


Gly His Asp Gln Asp His His Val His Ile Gly Gln Gly Lys Thr Leu 
    50                  55                  60                  


Leu Leu Thr Ser Ser Ala Thr Val Tyr Ser Ile His Ile Ser Glu Gly 
65                  70                  75                  80  


Gly Lys Leu Val Ile Lys Asp His Asp Glu Pro Ile Val Leu Arg Thr 
                85                  90                  95      


Arg His Ile Leu Ile Asp Asn Gly Gly Glu Leu His Ala Gly Ser Ala 
            100                 105                 110         


Leu Cys Pro Phe Gln Gly Asn Phe Thr Ile Ile Leu Tyr Gly Arg Ala 
        115                 120                 125             


Asp Glu Gly Ile Gln Pro Asp Pro Tyr Tyr Gly Leu Lys Tyr Ile Gly 
    130                 135                 140                 


Val Gly Lys Gly Gly Ala Leu Glu Leu His Gly Gln Lys Lys Leu Ser 
145                 150                 155                 160 


Trp Thr Phe Leu Asn Lys Thr Leu His Pro Gly Gly Met Ala Glu Gly 
                165                 170                 175     


Gly Tyr Phe Phe Glu Arg Ser Trp Gly His Arg Gly Val Ile Val His 
            180                 185                 190         


Val Ile Asp Pro Lys Ser Gly Thr Val Ile His Ser Asp Arg Phe Asp 
        195                 200                 205             


Thr Tyr Arg Ser Lys Lys Glu Ser Glu Arg Leu Val Gln Tyr Leu Asn 
    210                 215                 220                 


Ala Val Pro Asp Gly Arg Ile Leu Ser Val Ala Val Asn Asp Glu Gly 
225                 230                 235                 240 


Ser Arg Asn Leu Asp Asp Met Ala Arg Lys Ala Met Thr Lys Leu Gly 
                245                 250                 255     


Ser Lys His Phe Leu His Leu Gly Phe Arg His Pro Trp Ser Phe Leu 
            260                 265                 270         


Thr Val Lys Gly Asn Pro Ser Ser Ser Val Glu Asp His Ile Glu Tyr 
        275                 280                 285             


His Gly His Arg Gly Ser Ala Ala Ala Arg Val Phe Lys Leu Phe Gln 
    290                 295                 300                 


Thr Glu His Gly Glu Tyr Phe Asn Val Ser Leu Ser Ser Glu Trp Val 
305                 310                 315                 320 


Gln Asp Val Glu Trp Thr Glu Trp Phe Asp His Asp Lys Val Ser Gln 
                325                 330                 335     


Thr Lys Gly Gly Glu Lys Ile Ser Asp Leu Trp Lys Ala His Pro Gly 
            340                 345                 350         


Lys Ile Cys Asn Arg Pro Ile Asp Ile Gln Ala Thr Thr Met Asp Gly 
        355                 360                 365             


Val Asn Leu Ser Thr Glu Val Val Tyr Lys Lys Gly Gln Asp Tyr Arg 
    370                 375                 380                 


Phe Ala Cys Tyr Asp Arg Gly Arg Ala Cys Arg Ser Tyr Arg Val Arg 
385                 390                 395                 400 


Phe Leu Cys Gly Lys Pro Val Arg Pro Lys Leu Thr Val Thr Ile Asp 
                405                 410                 415     


Thr Asn Val Asn Ser Thr Ile Leu Asn Leu Glu Asp Asn Val Gln Ser 
            420                 425                 430         


Trp Lys Pro Gly Asp Thr Leu Val Ile Ala Ser Thr Asp Tyr Ser Met 
        435                 440                 445             


Tyr Gln Ala Glu Glu Phe Gln Val Leu Pro Cys Arg Ser Cys Ala Pro 
    450                 455                 460                 


Asn Gln Val Lys Val Ala Gly Lys Pro Met Tyr Leu His Ile Gly Glu 
465                 470                 475                 480 


Glu Ile Asp Gly Val Asp Met Arg Ala Glu Val Gly Leu Leu Ser Arg 
                485                 490                 495     


Asn Ile Ile Val Met Gly Glu Met Glu Asp Lys Cys Tyr Pro Tyr Arg 
            500                 505                 510         


Asn His Ile Cys Asn Phe Phe Asp Phe Asp Thr Phe Gly Gly His Ile 
        515                 520                 525             


Lys Phe Ala Leu Gly Phe Lys Ala Ala His Leu Glu Gly Thr Glu Leu 
    530                 535                 540                 


Lys His Met Gly Gln Gln Leu Val Gly Gln Tyr Pro Ile His Phe His 
545                 550                 555                 560 


Leu Ala Gly Asp Val Asp Glu Arg Gly Gly Tyr Asp Pro Pro Thr Tyr 
                565                 570                 575     


Ile Arg Asp Leu Ser Ile His His Thr Phe Ser Arg Cys Val Thr Val 
            580                 585                 590         


His Gly Ser Asn Gly Leu Leu Ile Lys Asp Val Val Gly Tyr Asn Ser 
        595                 600                 605             


Leu Gly His Cys Phe Phe Thr Glu Asp Gly Pro Glu Glu Arg Asn Thr 
    610                 615                 620                 


Phe Asp His Cys Leu Gly Leu Leu Val Lys Ser Gly Thr Leu Leu Pro 
625                 630                 635                 640 


Ser Asp Arg Asp Ser Lys Met Cys Lys Met Ile Thr Glu Asp Ser Tyr 
                645                 650                 655     


Pro Gly Tyr Ile Pro Lys Pro Arg Gln Asp Cys Asn Ala Val Ser Thr 
            660                 665                 670         


Phe Trp Met Ala Asn Pro Asn Asn Asn Leu Ile Asn Cys Ala Ala Ala 
        675                 680                 685             


Gly Ser Glu Glu Thr Gly Phe Trp Phe Ile Phe His His Val Pro Thr 
    690                 695                 700                 


Gly Pro Ser Val Gly Met Tyr Ser Pro Gly Tyr Ser Glu His Ile Pro 
705                 710                 715                 720 


Leu Gly Lys Phe Tyr Asn Asn Arg Ala His Ser Asn Tyr Arg Ala Gly 
                725                 730                 735     


Met Ile Ile Asp Asn Gly Val Lys Thr Thr Glu Ala Ser Ala Lys Asp 
            740                 745                 750         


Lys Arg Pro Phe Leu Ser Ile Ile Ser Ala Arg Tyr Ser Pro His Gln 
        755                 760                 765             


Asp Ala Asp Pro Leu Lys Pro Arg Glu Pro Ala Ile Ile Arg His Phe 
    770                 775                 780                 


Ile Ala Tyr Lys Asn Gln Asp His Gly Ala Trp Leu Arg Gly Gly Asp 
785                 790                 795                 800 


Val Trp Leu Asp Ser Ser Ala Ile Ser Glu Gly Arg Leu Arg Lys Ala 
                805                 810                 815     


Ser Cys Leu Gln Glu 
            820     

<210>  3189
<211>  7110
<212>  DNA
<213>  Homo sapiens

<400>  3189
aaaagcggcc tctcggctga gggccgggga gctagcgctc aagcagagcc cagcgcggtg     60

ctatcggaca gagcctggcg agcgcaagcg gcgcggggag ccagcggggc tgagcgcggc    120

cagggtctga acccagattt cccagactag ctaccactcc gcttgcccac gccccgggag    180

ctcgcggcgc ctggcggtca gcgaccagac gtccggggcc gctgcgctcc tggcccgcga    240

ggcgtgacac tgtctcggct acagacccag agggagcaca ctgccaggat gggagctgct    300

gggaggcagg acttcctctt caaggccatg ctgaccatca gctggctcac tctgacctgc    360

ttccctgggg ccacatccac agtggctgct gggtgccctg accagagccc tgagttgcaa    420

ccctggaacc ctggccatga ccaagaccac catgtgcata tcggccaggg caagacactg    480

ctgctcacct cttctgccac ggtctattcc atccacatct cagagggagg caagctggtc    540

attaaagacc acgacgagcc gattgttttg cgaacccggc acatcctgat tgacaacgga    600

ggagagctgc atgctgggag tgccctctgc cctttccagg gcaatttcac catcattttg    660

tatggaaggg ctgatgaagg tattcagccg gatccttact atggtctgaa gtacattggg    720

gttggtaaag gaggcgctct tgagttgcat ggacagaaaa agctctcctg gacatttctg    780

aacaagaccc ttcacccagg tggcatggca gaaggaggct atttttttga aaggagctgg    840

ggccaccgtg gagttattgt tcatgtcatc gaccccaaat caggcacagt catccattct    900

gaccggtttg acacctatag atccaagaaa gagagtgaac gtctggtcca gtatttgaac    960

gcggtgcccg atggcaggat cctttctgtt gcagtgaatg atgaaggttc tcgaaatctg   1020

gatgacatgg ccaggaaggc gatgaccaaa ttgggaagca aacacttcct gcaccttgga   1080

tttagacacc cttggagttt tctaactgtg aaaggaaatc catcatcttc agtggaagac   1140

catattgaat atcatggaca tcgaggctct gctgctgccc gggtattcaa attgttccag   1200

acagagcatg gcgaatattt caatgtttct ttgtccagtg agtgggttca agacgtggag   1260

tggacggagt ggttcgatca tgataaagta tctcagacta aaggtgggga gaaaatttca   1320

gacctctgga aagctcaccc aggaaaaata tgcaatcgtc ccattgatat acaggccact   1380

acaatggatg gagttaacct cagcaccgag gttgtctaca aaaaaggcca ggattatagg   1440

tttgcttgct acgaccgggg cagagcctgc cggagctacc gtgtacggtt cctctgtggg   1500

aagcctgtga ggcccaaact cacagtcacc attgacacca atgtgaacag caccattctg   1560

aacttggagg ataatgtaca gtcatggaaa cctggagata ccctggtcat tgccagtact   1620

gattactcca tgtaccaggc agaagagttc caggtgcttc cctgcagatc ctgcgccccc   1680

aaccaggtca aagtggcagg gaaaccaatg tacctgcaca tcggggagga gatagacggc   1740

gtggacatgc gggcggaggt tgggcttctg agccggaaca tcatagtgat gggggagatg   1800

gaggacaaat gctaccccta cagaaaccac atctgcaatt tctttgactt cgataccttt   1860

gggggccaca tcaagtttgc tctgggattt aaggcagcac acttggaggg cacggagctg   1920

aagcatatgg gacagcagct ggtgggtcag tacccgattc acttccacct ggccggtgat   1980

gtagacgaaa ggggaggtta tgacccaccc acatacatca gggacctctc catccatcat   2040

acattctctc gctgcgtcac agtccatggc tccaatggct tgttgatcaa ggacgttgtg   2100

ggctataact ctttgggcca ctgcttcttc acggaagatg ggccggagga acgcaacact   2160

tttgaccact gtcttggcct ccttgtcaag tctggaaccc tcctcccctc ggaccgtgac   2220

agcaagatgt gcaagatgat cacagaggac tcctacccgg ggtacatccc caagcccagg   2280

caagactgca atgctgtgtc caccttctgg atggccaatc ccaacaacaa cctcatcaac   2340

tgtgccgctg caggatctga ggaaactgga ttttggttta tttttcacca cgtaccaacg   2400

ggcccctccg tgggaatgta ctccccaggt tattcagagc acattccact gggaaaattc   2460

tataacaacc gagcacattc caactaccgg gctggcatga tcatagacaa cggagtcaaa   2520

accaccgagg cctctgccaa ggacaagcgg ccgttcctct caatcatctc tgccagatac   2580

agccctcacc aggacgccga cccgctgaag ccccgggagc cggccatcat cagacacttc   2640

attgcctaca agaaccagga ccacggggcc tggctgcgcg gcggggatgt gtggctggac   2700

agctgccggt ttgctgacaa tggcattggc ctgaccctgg ccagtggtgg aaccttcccg   2760

tatgacgacg gctccaagca agagataaag aacagcttgt ttgttggcga gagtggcaac   2820

gtggggacgg aaatgatgga caataggatc tggggccctg gcggcttgga ccatagcgga   2880

aggaccctcc ctataggcca gaattttcca attagaggaa ttcagttata tgatggcccc   2940

atcaacatcc aaaactgcac tttccgaaag tttgtggccc tggagggccg gcacaccagc   3000

gccctggcct tccgcctgaa taatgcctgg cagagctgcc cccataacaa cgtgaccggc   3060

attgcctttg aggacgttcc gattacttcc agagtgttct tcggagagcc tgggccctgg   3120

ttcaaccagc tggacatgga tggggataag acatctgtgt tccatgacgt cgacggctcc   3180

gtgtccgagt accctggctc ctacctcacg aagaatgaca actggctggt ccggcaccca   3240

gactgcatca atgttcccga ctggagaggg gccatttgca gtgggtgcta tgcacagatg   3300

tacattcaag cctacaagac cagtaacctg cgaatgaaga tcatcaagaa tgacttcccc   3360

agccaccctc tttacctgga gggggcgctc accaggagca cccattacca gcaataccaa   3420

ccggttgtca ccctgcagaa gggctacacc atccactggg accagacggc ccccgccgaa   3480

ctcgccatct ggctcatcaa cttcaacaag ggcgactgga tccgagtggg gctctgctac   3540

ccgcgaggca ccacattctc catcctctcg gatgttcaca atcgcctgct gaagcaaacg   3600

tccaagacgg gcgtcttcgt gaggaccttg cagatggaca aagtggagca gagctaccct   3660

ggcaggagcc actactactg ggacgaggac tcagggctgt tgttcctgaa gctgaaagct   3720

cagaacgaga gagagaagtt tgctttctgc tccatgaaag gctgtgagag gataaagatt   3780

aaagctctga ttccaaagaa cgcaggcgtc agtgactgca cagccacagc ttaccccaag   3840

ttcaccgaga gggctgtcgt agacgtgccg atgcccaaga agctctttgg ttctcagctg   3900

aaaacaaagg accatttctt ggaggtgaag atggagagtt ccaagcagca cttcttccac   3960

ctctggaacg acttcgctta cattgaagtg gatgggaaga agtaccccag ttcggaggat   4020

ggcatccagg tggtggtgat tgacgggaac caagggcgcg tggtgagcca cacgagcttc   4080

aggaactcca ttctgcaagg cataccatgg cagcttttca actatgtggc gaccatccct   4140

gacaattcca tagtgcttat ggcatcaaag ggaagatacg tctccagagg cccatggacc   4200

agagtgctgg aaaagcttgg ggcagacagg ggtctcaagt tgaaagagca aatggcattc   4260

gttggcttca aaggcagctt ccggcccatc tgggtgacac tggacactga ggatcacaaa   4320

gccaaaatct tccaagttgt gcccatccct gtggtgaaga agaagaagtt gtgaggacag   4380

ctgccgcccg gtgccacctc gtggtagact atgacggtga ctcttggcag cagaccagtg   4440

ggggatggct gggtccccca gcccctgcca gcagctgcct gggaaggccg tgtttcagcc   4500

ctgatgggcc aagggaaggc tatcagagac cctggtgctg ccacctgccc ctactcaagt   4560

gtctacctgg agcccctggg gcggtgctgg ccaatgctgg aaacattcac tttcctgcag   4620

cctcttgggt gcttctctcc tatctgtgcc tcttcagtgg gggtttgggg accatatcag   4680

gagacctggg ttgtgctgac agcaaagatc cactttggca ggagccctga cccagctagg   4740

aggtagtctg gagggctggt cattcacaga tccccatggt cttcagcaga caagtgaggg   4800

tggtaaatgt aggagaaaga gccttggcct taaggaaatc tttactcctg taagcaagag   4860

ccaacctcac aggattagga gctggggtag aactggctat ccttggggaa gaggcaagcc   4920

ctgcctctgg ccgtgtccac ctttcaggag actttgagtg gcaggtttgg acttggacta   4980

gatgactctc aaaggccctt ttagttctga gattccagaa atctgctgca tttcacatgg   5040

tacctggaac ccaacagttc atggatatcc actgatatcc atgatgctgg gtgccccagc   5100

gcacacggga tggagaggtg agaactaatg cctagcttga ggggtctgca gtccagtagg   5160

gcaggcagtc aggtccatgt gcactgcaat gccaggtgga gaaatcacag agaggtaaaa   5220

tggaggccag tgccatttca gaggggaggc tcaggaaggc ttcttgctta caggaatgaa   5280

ggctgggggc attttgctgg ggggagatga ggcagcctct ggaatggctc agggattcag   5340

ccctccctgc cgctgcctgc tgaagctggt gactacgggg tcgccctttg ctcacgtctc   5400

tctggcccac tcatgatgga gaagtgtggt cagaggggag caatgggctt tgctgcttat   5460

gagcacagag gaattcagtc cccaggcagc cctgcctctg actccaagag ggtgaagtcc   5520

acagaagtga gctcctgcct tagggcctca tttgctcttc atccagggaa ctgagcacag   5580

ggggcctcca ggagacccta gatgtgctcg tactccctcg gcctgggatt tcagagctgg   5640

aaatatagaa aatatctagc ccaaagcctt cattttaaca gatggggaaa gtgagccccc   5700

aagatgggaa agaaccacac agctaaggga gggcctgggg agccccaccc tagcccttgc   5760

tgccacacca cattgcctca acaaccggcc ccagagtgcc caggcactcc tgaggtagct   5820

tctggaaatg gggacaagtc ccctcgaagg aaaggaaatg actagagtag aatgacagct   5880

agcagatctc ttccctcctg ctcccagcgc acacaaaccc gccctcccct tggtgttggc   5940

ggtccctgtg gccttcactt tgttcactac ctgtcagccc agcctgggtg cacagtagct   6000

gcaactcccc attggtgcta cctggctctc ctgtctctgc agctctacag gtgaggccca   6060

gcagagggag tagggctcgc catgtttctg gtgagccaat ttggctgatc ttgggtgtct   6120

gaacagctat tgggtccacc ccagtccctt tcagctgctg cttaatgccc tgctctctcc   6180

ctggcccacc ttatagagag cccaaagagc tcctgtaaga gggagaactc tatctgtggt   6240

ttataatctt gcacgaggca ccagagtctc cctgggtctt gtgatgaact acatttatcc   6300

cctttcctgc cccaaccaca aactctttcc ttcaaagagg gcctgcctgg ctccctccac   6360

ccaactgcac ccatgagact cggtccaaga gtccattccc caggtgggag ccaactgtca   6420

gggaggtctt tcccaccaaa catctttcag ctgctgggag gtgaccatag ggctctgctt   6480

ttaaagatat ggctgcttca aaggccagag tcacaggaag gacttcttcc agggagatta   6540

gtggtgatgg agaggagagt taaaatgacc tcatgtcctt cttgtccacg gttttgttga   6600

gttttcactc ttctaatgca agggtctcac actgtgaacc acttaggatg tgatcacttt   6660

caggtggcca ggaatgttga atgtctttgg ctcagttcat ttaaaaaaga tatctatttg   6720

aaagttctca gagttgtaca tatgtttcac agtacaggat ctgtacataa aagtttcttt   6780

cctaaaccat tcaccaagag ccaatatcta ggcattttct tggtagcaca aattttctta   6840

ttgcttagaa aattgtcctc cttgttattt ctgtttgtaa gacttaagtg agttaggtct   6900

ttaaggaaag caacgctcct ctgaaatgct tgtctttttt ctgttgccga aatagctggt   6960

cctttttcgg gagttagatg tatagagtgt ttgtatgtaa acatttcttg taggcatcac   7020

catgaacaaa gatatatttt ctatttattt attatatgtg cacttcaaga agtcactgtc   7080

agagaaataa agaattgtct taaatgtcat                                    7110


<210>  3190
<211>  1361
<212>  PRT
<213>  Homo sapiens

<400>  3190


Met Gly Ala Ala Gly Arg Gln Asp Phe Leu Phe Lys Ala Met Leu Thr 
1               5                   10                  15      


Ile Ser Trp Leu Thr Leu Thr Cys Phe Pro Gly Ala Thr Ser Thr Val 
            20                  25                  30          


Ala Ala Gly Cys Pro Asp Gln Ser Pro Glu Leu Gln Pro Trp Asn Pro 
        35                  40                  45              


Gly His Asp Gln Asp His His Val His Ile Gly Gln Gly Lys Thr Leu 
    50                  55                  60                  


Leu Leu Thr Ser Ser Ala Thr Val Tyr Ser Ile His Ile Ser Glu Gly 
65                  70                  75                  80  


Gly Lys Leu Val Ile Lys Asp His Asp Glu Pro Ile Val Leu Arg Thr 
                85                  90                  95      


Arg His Ile Leu Ile Asp Asn Gly Gly Glu Leu His Ala Gly Ser Ala 
            100                 105                 110         


Leu Cys Pro Phe Gln Gly Asn Phe Thr Ile Ile Leu Tyr Gly Arg Ala 
        115                 120                 125             


Asp Glu Gly Ile Gln Pro Asp Pro Tyr Tyr Gly Leu Lys Tyr Ile Gly 
    130                 135                 140                 


Val Gly Lys Gly Gly Ala Leu Glu Leu His Gly Gln Lys Lys Leu Ser 
145                 150                 155                 160 


Trp Thr Phe Leu Asn Lys Thr Leu His Pro Gly Gly Met Ala Glu Gly 
                165                 170                 175     


Gly Tyr Phe Phe Glu Arg Ser Trp Gly His Arg Gly Val Ile Val His 
            180                 185                 190         


Val Ile Asp Pro Lys Ser Gly Thr Val Ile His Ser Asp Arg Phe Asp 
        195                 200                 205             


Thr Tyr Arg Ser Lys Lys Glu Ser Glu Arg Leu Val Gln Tyr Leu Asn 
    210                 215                 220                 


Ala Val Pro Asp Gly Arg Ile Leu Ser Val Ala Val Asn Asp Glu Gly 
225                 230                 235                 240 


Ser Arg Asn Leu Asp Asp Met Ala Arg Lys Ala Met Thr Lys Leu Gly 
                245                 250                 255     


Ser Lys His Phe Leu His Leu Gly Phe Arg His Pro Trp Ser Phe Leu 
            260                 265                 270         


Thr Val Lys Gly Asn Pro Ser Ser Ser Val Glu Asp His Ile Glu Tyr 
        275                 280                 285             


His Gly His Arg Gly Ser Ala Ala Ala Arg Val Phe Lys Leu Phe Gln 
    290                 295                 300                 


Thr Glu His Gly Glu Tyr Phe Asn Val Ser Leu Ser Ser Glu Trp Val 
305                 310                 315                 320 


Gln Asp Val Glu Trp Thr Glu Trp Phe Asp His Asp Lys Val Ser Gln 
                325                 330                 335     


Thr Lys Gly Gly Glu Lys Ile Ser Asp Leu Trp Lys Ala His Pro Gly 
            340                 345                 350         


Lys Ile Cys Asn Arg Pro Ile Asp Ile Gln Ala Thr Thr Met Asp Gly 
        355                 360                 365             


Val Asn Leu Ser Thr Glu Val Val Tyr Lys Lys Gly Gln Asp Tyr Arg 
    370                 375                 380                 


Phe Ala Cys Tyr Asp Arg Gly Arg Ala Cys Arg Ser Tyr Arg Val Arg 
385                 390                 395                 400 


Phe Leu Cys Gly Lys Pro Val Arg Pro Lys Leu Thr Val Thr Ile Asp 
                405                 410                 415     


Thr Asn Val Asn Ser Thr Ile Leu Asn Leu Glu Asp Asn Val Gln Ser 
            420                 425                 430         


Trp Lys Pro Gly Asp Thr Leu Val Ile Ala Ser Thr Asp Tyr Ser Met 
        435                 440                 445             


Tyr Gln Ala Glu Glu Phe Gln Val Leu Pro Cys Arg Ser Cys Ala Pro 
    450                 455                 460                 


Asn Gln Val Lys Val Ala Gly Lys Pro Met Tyr Leu His Ile Gly Glu 
465                 470                 475                 480 


Glu Ile Asp Gly Val Asp Met Arg Ala Glu Val Gly Leu Leu Ser Arg 
                485                 490                 495     


Asn Ile Ile Val Met Gly Glu Met Glu Asp Lys Cys Tyr Pro Tyr Arg 
            500                 505                 510         


Asn His Ile Cys Asn Phe Phe Asp Phe Asp Thr Phe Gly Gly His Ile 
        515                 520                 525             


Lys Phe Ala Leu Gly Phe Lys Ala Ala His Leu Glu Gly Thr Glu Leu 
    530                 535                 540                 


Lys His Met Gly Gln Gln Leu Val Gly Gln Tyr Pro Ile His Phe His 
545                 550                 555                 560 


Leu Ala Gly Asp Val Asp Glu Arg Gly Gly Tyr Asp Pro Pro Thr Tyr 
                565                 570                 575     


Ile Arg Asp Leu Ser Ile His His Thr Phe Ser Arg Cys Val Thr Val 
            580                 585                 590         


His Gly Ser Asn Gly Leu Leu Ile Lys Asp Val Val Gly Tyr Asn Ser 
        595                 600                 605             


Leu Gly His Cys Phe Phe Thr Glu Asp Gly Pro Glu Glu Arg Asn Thr 
    610                 615                 620                 


Phe Asp His Cys Leu Gly Leu Leu Val Lys Ser Gly Thr Leu Leu Pro 
625                 630                 635                 640 


Ser Asp Arg Asp Ser Lys Met Cys Lys Met Ile Thr Glu Asp Ser Tyr 
                645                 650                 655     


Pro Gly Tyr Ile Pro Lys Pro Arg Gln Asp Cys Asn Ala Val Ser Thr 
            660                 665                 670         


Phe Trp Met Ala Asn Pro Asn Asn Asn Leu Ile Asn Cys Ala Ala Ala 
        675                 680                 685             


Gly Ser Glu Glu Thr Gly Phe Trp Phe Ile Phe His His Val Pro Thr 
    690                 695                 700                 


Gly Pro Ser Val Gly Met Tyr Ser Pro Gly Tyr Ser Glu His Ile Pro 
705                 710                 715                 720 


Leu Gly Lys Phe Tyr Asn Asn Arg Ala His Ser Asn Tyr Arg Ala Gly 
                725                 730                 735     


Met Ile Ile Asp Asn Gly Val Lys Thr Thr Glu Ala Ser Ala Lys Asp 
            740                 745                 750         


Lys Arg Pro Phe Leu Ser Ile Ile Ser Ala Arg Tyr Ser Pro His Gln 
        755                 760                 765             


Asp Ala Asp Pro Leu Lys Pro Arg Glu Pro Ala Ile Ile Arg His Phe 
    770                 775                 780                 


Ile Ala Tyr Lys Asn Gln Asp His Gly Ala Trp Leu Arg Gly Gly Asp 
785                 790                 795                 800 


Val Trp Leu Asp Ser Cys Arg Phe Ala Asp Asn Gly Ile Gly Leu Thr 
                805                 810                 815     


Leu Ala Ser Gly Gly Thr Phe Pro Tyr Asp Asp Gly Ser Lys Gln Glu 
            820                 825                 830         


Ile Lys Asn Ser Leu Phe Val Gly Glu Ser Gly Asn Val Gly Thr Glu 
        835                 840                 845             


Met Met Asp Asn Arg Ile Trp Gly Pro Gly Gly Leu Asp His Ser Gly 
    850                 855                 860                 


Arg Thr Leu Pro Ile Gly Gln Asn Phe Pro Ile Arg Gly Ile Gln Leu 
865                 870                 875                 880 


Tyr Asp Gly Pro Ile Asn Ile Gln Asn Cys Thr Phe Arg Lys Phe Val 
                885                 890                 895     


Ala Leu Glu Gly Arg His Thr Ser Ala Leu Ala Phe Arg Leu Asn Asn 
            900                 905                 910         


Ala Trp Gln Ser Cys Pro His Asn Asn Val Thr Gly Ile Ala Phe Glu 
        915                 920                 925             


Asp Val Pro Ile Thr Ser Arg Val Phe Phe Gly Glu Pro Gly Pro Trp 
    930                 935                 940                 


Phe Asn Gln Leu Asp Met Asp Gly Asp Lys Thr Ser Val Phe His Asp 
945                 950                 955                 960 


Val Asp Gly Ser Val Ser Glu Tyr Pro Gly Ser Tyr Leu Thr Lys Asn 
                965                 970                 975     


Asp Asn Trp Leu Val Arg His Pro Asp Cys Ile Asn Val Pro Asp Trp 
            980                 985                 990         


Arg Gly Ala Ile Cys Ser Gly Cys  Tyr Ala Gln Met Tyr  Ile Gln Ala 
        995                 1000                 1005             


Tyr Lys  Thr Ser Asn Leu Arg  Met Lys Ile Ile Lys  Asn Asp Phe 
    1010                 1015                 1020             


Pro Ser  His Pro Leu Tyr Leu  Glu Gly Ala Leu Thr  Arg Ser Thr 
    1025                 1030                 1035             


His Tyr  Gln Gln Tyr Gln Pro  Val Val Thr Leu Gln  Lys Gly Tyr 
    1040                 1045                 1050             


Thr Ile  His Trp Asp Gln Thr  Ala Pro Ala Glu Leu  Ala Ile Trp 
    1055                 1060                 1065             


Leu Ile  Asn Phe Asn Lys Gly  Asp Trp Ile Arg Val  Gly Leu Cys 
    1070                 1075                 1080             


Tyr Pro  Arg Gly Thr Thr Phe  Ser Ile Leu Ser Asp  Val His Asn 
    1085                 1090                 1095             


Arg Leu  Leu Lys Gln Thr Ser  Lys Thr Gly Val Phe  Val Arg Thr 
    1100                 1105                 1110             


Leu Gln  Met Asp Lys Val Glu  Gln Ser Tyr Pro Gly  Arg Ser His 
    1115                 1120                 1125             


Tyr Tyr  Trp Asp Glu Asp Ser  Gly Leu Leu Phe Leu  Lys Leu Lys 
    1130                 1135                 1140             


Ala Gln  Asn Glu Arg Glu Lys  Phe Ala Phe Cys Ser  Met Lys Gly 
    1145                 1150                 1155             


Cys Glu  Arg Ile Lys Ile Lys  Ala Leu Ile Pro Lys  Asn Ala Gly 
    1160                 1165                 1170             


Val Ser  Asp Cys Thr Ala Thr  Ala Tyr Pro Lys Phe  Thr Glu Arg 
    1175                 1180                 1185             


Ala Val  Val Asp Val Pro Met  Pro Lys Lys Leu Phe  Gly Ser Gln 
    1190                 1195                 1200             


Leu Lys  Thr Lys Asp His Phe  Leu Glu Val Lys Met  Glu Ser Ser 
    1205                 1210                 1215             


Lys Gln  His Phe Phe His Leu  Trp Asn Asp Phe Ala  Tyr Ile Glu 
    1220                 1225                 1230             


Val Asp  Gly Lys Lys Tyr Pro  Ser Ser Glu Asp Gly  Ile Gln Val 
    1235                 1240                 1245             


Val Val  Ile Asp Gly Asn Gln  Gly Arg Val Val Ser  His Thr Ser 
    1250                 1255                 1260             


Phe Arg  Asn Ser Ile Leu Gln  Gly Ile Pro Trp Gln  Leu Phe Asn 
    1265                 1270                 1275             


Tyr Val  Ala Thr Ile Pro Asp  Asn Ser Ile Val Leu  Met Ala Ser 
    1280                 1285                 1290             


Lys Gly  Arg Tyr Val Ser Arg  Gly Pro Trp Thr Arg  Val Leu Glu 
    1295                 1300                 1305             


Lys Leu  Gly Ala Asp Arg Gly  Leu Lys Leu Lys Glu  Gln Met Ala 
    1310                 1315                 1320             


Phe Val  Gly Phe Lys Gly Ser  Phe Arg Pro Ile Trp  Val Thr Leu 
    1325                 1330                 1335             


Asp Thr  Glu Asp His Lys Ala  Lys Ile Phe Gln Val  Val Pro Ile 
    1340                 1345                 1350             


Pro Val  Val Lys Lys Lys Lys  Leu 
    1355                 1360     

<210>  3191
<211>  7226
<212>  DNA
<213>  Homo sapiens

<400>  3191
aaaagcggcc tctcggctga gggccgggga gctagcgctc aagcagagcc cagcgcggtg     60

ctatcggaca gagcctggcg agcgcaagcg gcgcggggag ccagcggggc tgagcgcggc    120

cagggtctga acccagattt cccagactag ctaccactcc gcttgcccac gccccgggag    180

ctcgcggcgc ctggcggtca gcgaccagac gtccggggcc gctgcgctcc tggcccgcga    240

ggcgtgacac tgtctcggct acagacccag agggagcaca ctgccaggat gggagctgct    300

gggaggcagg acttcctctt caaggccatg ctgaccatca gctggctcac tctgacctgc    360

ttccctgggg ccacatccac agtggctgct gggtgccctg accagagccc tgagttgcaa    420

ccctggaacc ctggccatga ccaagaccac catgtgcata tcggccaggg caagacactg    480

ctgctcacct cttctgccac ggtctattcc atccacatct cagagggagg caagctggtc    540

attaaagacc acgacgagcc gattgttttg cgaacccggc acatcctgat tgacaacgga    600

ggagagctgc atgctgggag tgccctctgc cctttccagg gcaatttcac catcattttg    660

tatggaaggg ctgatgaagg tattcagccg gatccttact atggtctgaa gtacattggg    720

gttggtaaag gaggcgctct tgagttgcat ggacagaaaa agctctcctg gacatttctg    780

aacaagaccc ttcacccagg tggcatggca gaaggaggct atttttttga aaggagctgg    840

ggccaccgtg gagttattgt tcatgtcatc gaccccaaat caggcacagt catccattct    900

gaccggtttg acacctatag atccaagaaa gagagtgaac gtctggtcca gtatttgaac    960

gcggtgcccg atggcaggat cctttctgtt gcagtgaatg atgaaggttc tcgaaatctg   1020

gatgacatgg ccaggaaggc gatgaccaaa ttgggaagca aacacttcct gcaccttgga   1080

tttagacacc cttggagttt tctaactgtg aaaggaaatc catcatcttc agtggaagac   1140

catattgaat atcatggaca tcgaggctct gctgctgccc gggtattcaa attgttccag   1200

acagagcatg gcgaatattt caatgtttct ttgtccagtg agtgggttca agacgtggag   1260

tggacggagt ggttcgatca tgataaagta tctcagacta aaggtgggga gaaaatttca   1320

gacctctgga aagctcaccc aggaaaaata tgcaatcgtc ccattgatat acaggccact   1380

acaatggatg gagttaacct cagcaccgag gttgtctaca aaaaaggcca ggattatagg   1440

tttgcttgct acgaccgggg cagagcctgc cggagctacc gtgtacggtt cctctgtggg   1500

aagcctgtga ggcccaaact cacagtcacc attgacacca atgtgaacag caccattctg   1560

aacttggagg ataatgtaca gtcatggaaa cctggagata ccctggtcat tgccagtact   1620

gattactcca tgtaccaggc agaagagttc caggtgcttc cctgcagatc ctgcgccccc   1680

aaccaggtca aagtggcagg gaaaccaatg tacctgcaca tcggggagga gatagacggc   1740

gtggacatgc gggcggaggt tgggcttctg agccggaaca tcatagtgat gggggagatg   1800

gaggacaaat gctaccccta cagaaaccac atctgcaatt tctttgactt cgataccttt   1860

gggggccaca tcaagtttgc tctgggattt aaggcagcac acttggaggg cacggagctg   1920

aagcatatgg gacagcagct ggtgggtcag tacccgattc acttccacct ggccggtgat   1980

gtagacgaaa ggggaggtta tgacccaccc acatacatca gggacctctc catccatcat   2040

acattctctc gctgcgtcac agtccatggc tccaatggct tgttgatcaa ggacgttgtg   2100

ggctataact ctttgggcca ctgcttcttc acggaagatg ggccggagga acgcaacact   2160

tttgaccact gtcttggcct ccttgtcaag tctggaaccc tcctcccctc ggaccgtgac   2220

agcaagatgt gcaagatgat cacagaggac tcctacccgg ggtacatccc caagcccagg   2280

caagactgca atgctgtgtc caccttctgg atggccaatc ccaacaacaa cctcatcaac   2340

tgtgccgctg caggatctga ggaaactgga ttttggttta tttttcacca cgtaccaacg   2400

ggcccctccg tgggaatgta ctccccaggt tattcagagc acattccact gggaaaattc   2460

tataacaacc gagcacattc caactaccgg gctggcatga tcatagacaa cggagtcaaa   2520

accaccgagg cctctgccaa ggacaagcgg ccgttcctct caatcatctc tgccagatac   2580

agccctcacc aggacgccga cccgctgaag ccccgggagc cggccatcat cagacacttc   2640

attgcctaca agaaccagga ccacggggcc tggctgcgcg gcggggatgt gtggctggac   2700

agctgccggt ttgctgacaa tggcattggc ctgaccctgg ccagtggtgg aaccttcccg   2760

tatgacgacg gctccaagca agagataaag aacagcttgt ttgttggcga gagtggcaac   2820

gtggggacgg aaatgatgga caataggatc tggggccctg gcggcttgga ccatagcgga   2880

aggaccctcc ctataggcca gaattttcca attagaggaa ttcagttata tgatggcccc   2940

atcaacatcc aaaactgcac tttccgaaag tttgtggccc tggagggccg gcacaccagc   3000

gccctggcct tccgcctgaa taatgcctgg cagagctgcc cccataacaa cgtgaccggc   3060

attgcctttg aggacgttcc gattacttcc agagtgttct tcggagagcc tgggccctgg   3120

ttcaaccagc tggacatgga tggggataag acatctgtgt tccatgacgt cgacggctcc   3180

gtgtccgagt accctggctc ctacctcacg aagaatgaca actggctggt ccggcaccca   3240

gactgcatca atgttcccga ctggagaggg gccatttgca gtgggtgcta tgcacagatg   3300

tacattcaag cctacaagac cagtaacctg cgaatgaaga tcatcaagaa tgacttcccc   3360

agccaccctc tttacctgga gggggcgctc accaggagca cccattacca gcaataccaa   3420

ccggttgtca ccctgcagaa gggctacacc atccactggg accagacggc ccccgccgaa   3480

ctcgccatct ggctcatcaa cttcaacaag ggcgactgga tccgagtggg gctctgctac   3540

ccgcgaggca ccacattctc catcctctcg gatgttcaca atcgcctgct gaagcaaacg   3600

tccaagacgg gcgtcttcgt gaggaccttg cagatggaca aagtggagca gagctaccct   3660

ggcaggagcc actactactg ggacgaggac tcagggctgt tgttcctgaa gctgaaagct   3720

cagaacgaga gagagaagtt tgctttctgc tccatgaaag gctgtgagag gataaagatt   3780

aaagctctga ttccaaagaa cgcaggcgtc agtgactgca cagccacagc ttaccccaag   3840

ttcaccgaga gggctgtcgt agacgtgccg atgcccaaga agctctttgg ttctcagctg   3900

aaaacaaagg accatttctt ggaggtgaag atggagagtt ccaagcagca cttcttccac   3960

ctctggaacg acttcgctta cattgaagtg gatgggaaga agtaccccag ttcggaggat   4020

ggcatccagg tggtggtgat tgacgggaac caagggcgcg tggtgagcca cacgagcttc   4080

aggaactcca ttctgcaagg cataccatgg cagcttttca actatgtggc gaccatccct   4140

gacaattcca tagtgcttat ggcatcaaag ggaagatacg tctccagagg cccatggacc   4200

agagtgctgg aaaagcttgg ggcagacagg ggtctcaagt tgaaagagca aatggcattc   4260

gttggcttca aaggcagctt ccggcccatc tgggtgacac tggacactga ggatcacaaa   4320

gccaaaatct tccaagttgt gcccatccct gtggtgaaga agaagaagtt gtgaggacag   4380

ctgccgcccg gtgccacctc gtggtagact atgacggtga ctcttggcag cagaccagtg   4440

ggggatggct gggtccccca gcccctgcca gcagctgcct gggaaggccg tgtttcagcc   4500

ctgatgggcc aagggaaggc tatcagagac cctggtgctg ccacctgccc ctactcaagt   4560

gtctacctgg agcccctggg gcggtgctgg ccaatgctgg aaacattcac tttcctgcag   4620

cctcttgggt gcttctctcc tatctgtgcc tcttcagtgg gggtttgggg accatatcag   4680

gagacctggg ttgtgctgac agcaaagatc cactttggca ggagccctga cccagctagg   4740

aggtagtctg gagggctggt cattcacaga tccccatggt cttcagcaga caagtgaggg   4800

tggtaaatgt aggagaaaga gccttggcct taaggaaatc tttactcctg taagcaagag   4860

ccaacctcac aggattagga gctggggtag aactggctat ccttggggaa gaggcaagcc   4920

ctgcctctgg ccgtgtccac ctttcaggag actttgagtg gcaggtttgg acttggacta   4980

gatgactctc aaaggccctt ttagttctga gattccagaa atctgctgca tttcacatgg   5040

tacctggaac ccaacagttc atggatatcc actgatatcc atgatgctgg gtgccccagc   5100

gcacacggga tggagaggtg agaactaatg cctagcttga ggggtctgca gtccagtagg   5160

gcaggcagtc aggtccatgt gcactgcaat gccaggtgga gaaatcacag agaggtaaaa   5220

tggaggccag tgccatttca gaggggaggc tcaggaaggc ttcttgctta caggaatgaa   5280

ggctgggggc attttgctgg ggggagatga ggcagcctct ggaatggctc agggattcag   5340

ccctccctgc cgctgcctgc tgaagctggt gactacgggg tcgccctttg ctcacgtctc   5400

tctggcccac tcatgatgga gaagtgtggt cagaggggag caatgggctt tgctgcttat   5460

gagcacagag gaattcagtc cccaggcagc cctgcctctg actccaagag ggtgaagtcc   5520

acagaagtga gctcctgcct tagggcctca tttgctcttc atccagggaa ctgagcacag   5580

ggggcctcca ggagacccta gatgtgctcg tactccctcg gcctgggatt tcagagctgg   5640

aaatatagaa aatatctagc ccaaagcctt cattttaaca gatggggaaa gtgagccccc   5700

aagatgggaa agaaccacac agctaaggga gggcctgggg agccccaccc tagcccttgc   5760

tgccacacca cattgcctca acaaccggcc ccagagtgcc caggcactcc tgaggtagct   5820

tctggaaatg gggacaagtc ccctcgaagg aaaggaaatg actagagtag aatgacagct   5880

agcagatctc ttccctcctg ctcccagcgc acacaaaccc gccctcccct tggtgttggc   5940

ggtccctgtg gccttcactt tgttcactac ctgtcagccc agcctgggtg cacagtagct   6000

gcaactcccc attggtgcta cctggctctc ctgtctctgc agctctacag gtgaggccca   6060

gcagagggag tagggctcgc catgtttctg gtgagccaat ttggctgatc ttgggtgtct   6120

gaacagctat tgggtccacc ccagtccctt tcagctgctg cttaatgccc tgctctctcc   6180

ctggcccacc ttatagagag cccaaagagc tcctgtaaga gggagaactc tatctgtggt   6240

ttataatctt gcacgaggca ccagagtctc cctgggtctt gtgatgaact acatttatcc   6300

cctttcctgc cccaaccaca aactctttcc ttcaaagagg gcctgcctgg ctccctccac   6360

ccaactgcac ccatgagact cggtccaaga gtccattccc caggtgggag ccaactgtca   6420

gggaggtctt tcccaccaaa catctttcag ctgctgggag gtgaccatag ggctctgctt   6480

ttaaagatat ggctgcttca aaggccagag tcacaggaag gacttcttcc agggagatta   6540

gtggtgatgg agaggagagt taaaatgacc tcatgtcctt cttgtccacg gttttgttga   6600

gttttcactc ttctaatgca agggtctcac actgtgaacc acttaggatg tgatcacttt   6660

caggtggcca ggaatgttga atgtctttgg ctcagttcat ttaaaaaaga tatctatttg   6720

aaagttctca gagttgtaca tatgtttcac agtacaggat ctgtacataa aagtttcttt   6780

cctaaaccat tcaccaagag ccaatatcta ggcattttct tggtagcaca aattttctta   6840

ttgcttagaa aattgtcctc cttgttattt ctgtttgtaa gacttaagtg agttaggtct   6900

ttaaggaaag caacgctcct ctgaaatgct tgtctttttt ctgttgccga aatagctggt   6960

cctttttcgg gagttagatg tatagagtgt ttgtatgtaa acatttcttg taggcatcac   7020

catgaacaaa gatatatttt ctatttattt attatatgtg cacttcaaga agtcactgtc   7080

agagaaataa agaattgtct taaatgtcat gattggagat gtcctttgca ttgcttggaa   7140

ggggtgtacc tagagccaag gaaattggct ctggtttgga aaaattttgc tgttattata   7200

gtaaacatac aaaggatgtc atcatc                                        7226


<210>  3192
<211>  1361
<212>  PRT
<213>  Homo sapiens

<400>  3192


Met Gly Ala Ala Gly Arg Gln Asp Phe Leu Phe Lys Ala Met Leu Thr 
1               5                   10                  15      


Ile Ser Trp Leu Thr Leu Thr Cys Phe Pro Gly Ala Thr Ser Thr Val 
            20                  25                  30          


Ala Ala Gly Cys Pro Asp Gln Ser Pro Glu Leu Gln Pro Trp Asn Pro 
        35                  40                  45              


Gly His Asp Gln Asp His His Val His Ile Gly Gln Gly Lys Thr Leu 
    50                  55                  60                  


Leu Leu Thr Ser Ser Ala Thr Val Tyr Ser Ile His Ile Ser Glu Gly 
65                  70                  75                  80  


Gly Lys Leu Val Ile Lys Asp His Asp Glu Pro Ile Val Leu Arg Thr 
                85                  90                  95      


Arg His Ile Leu Ile Asp Asn Gly Gly Glu Leu His Ala Gly Ser Ala 
            100                 105                 110         


Leu Cys Pro Phe Gln Gly Asn Phe Thr Ile Ile Leu Tyr Gly Arg Ala 
        115                 120                 125             


Asp Glu Gly Ile Gln Pro Asp Pro Tyr Tyr Gly Leu Lys Tyr Ile Gly 
    130                 135                 140                 


Val Gly Lys Gly Gly Ala Leu Glu Leu His Gly Gln Lys Lys Leu Ser 
145                 150                 155                 160 


Trp Thr Phe Leu Asn Lys Thr Leu His Pro Gly Gly Met Ala Glu Gly 
                165                 170                 175     


Gly Tyr Phe Phe Glu Arg Ser Trp Gly His Arg Gly Val Ile Val His 
            180                 185                 190         


Val Ile Asp Pro Lys Ser Gly Thr Val Ile His Ser Asp Arg Phe Asp 
        195                 200                 205             


Thr Tyr Arg Ser Lys Lys Glu Ser Glu Arg Leu Val Gln Tyr Leu Asn 
    210                 215                 220                 


Ala Val Pro Asp Gly Arg Ile Leu Ser Val Ala Val Asn Asp Glu Gly 
225                 230                 235                 240 


Ser Arg Asn Leu Asp Asp Met Ala Arg Lys Ala Met Thr Lys Leu Gly 
                245                 250                 255     


Ser Lys His Phe Leu His Leu Gly Phe Arg His Pro Trp Ser Phe Leu 
            260                 265                 270         


Thr Val Lys Gly Asn Pro Ser Ser Ser Val Glu Asp His Ile Glu Tyr 
        275                 280                 285             


His Gly His Arg Gly Ser Ala Ala Ala Arg Val Phe Lys Leu Phe Gln 
    290                 295                 300                 


Thr Glu His Gly Glu Tyr Phe Asn Val Ser Leu Ser Ser Glu Trp Val 
305                 310                 315                 320 


Gln Asp Val Glu Trp Thr Glu Trp Phe Asp His Asp Lys Val Ser Gln 
                325                 330                 335     


Thr Lys Gly Gly Glu Lys Ile Ser Asp Leu Trp Lys Ala His Pro Gly 
            340                 345                 350         


Lys Ile Cys Asn Arg Pro Ile Asp Ile Gln Ala Thr Thr Met Asp Gly 
        355                 360                 365             


Val Asn Leu Ser Thr Glu Val Val Tyr Lys Lys Gly Gln Asp Tyr Arg 
    370                 375                 380                 


Phe Ala Cys Tyr Asp Arg Gly Arg Ala Cys Arg Ser Tyr Arg Val Arg 
385                 390                 395                 400 


Phe Leu Cys Gly Lys Pro Val Arg Pro Lys Leu Thr Val Thr Ile Asp 
                405                 410                 415     


Thr Asn Val Asn Ser Thr Ile Leu Asn Leu Glu Asp Asn Val Gln Ser 
            420                 425                 430         


Trp Lys Pro Gly Asp Thr Leu Val Ile Ala Ser Thr Asp Tyr Ser Met 
        435                 440                 445             


Tyr Gln Ala Glu Glu Phe Gln Val Leu Pro Cys Arg Ser Cys Ala Pro 
    450                 455                 460                 


Asn Gln Val Lys Val Ala Gly Lys Pro Met Tyr Leu His Ile Gly Glu 
465                 470                 475                 480 


Glu Ile Asp Gly Val Asp Met Arg Ala Glu Val Gly Leu Leu Ser Arg 
                485                 490                 495     


Asn Ile Ile Val Met Gly Glu Met Glu Asp Lys Cys Tyr Pro Tyr Arg 
            500                 505                 510         


Asn His Ile Cys Asn Phe Phe Asp Phe Asp Thr Phe Gly Gly His Ile 
        515                 520                 525             


Lys Phe Ala Leu Gly Phe Lys Ala Ala His Leu Glu Gly Thr Glu Leu 
    530                 535                 540                 


Lys His Met Gly Gln Gln Leu Val Gly Gln Tyr Pro Ile His Phe His 
545                 550                 555                 560 


Leu Ala Gly Asp Val Asp Glu Arg Gly Gly Tyr Asp Pro Pro Thr Tyr 
                565                 570                 575     


Ile Arg Asp Leu Ser Ile His His Thr Phe Ser Arg Cys Val Thr Val 
            580                 585                 590         


His Gly Ser Asn Gly Leu Leu Ile Lys Asp Val Val Gly Tyr Asn Ser 
        595                 600                 605             


Leu Gly His Cys Phe Phe Thr Glu Asp Gly Pro Glu Glu Arg Asn Thr 
    610                 615                 620                 


Phe Asp His Cys Leu Gly Leu Leu Val Lys Ser Gly Thr Leu Leu Pro 
625                 630                 635                 640 


Ser Asp Arg Asp Ser Lys Met Cys Lys Met Ile Thr Glu Asp Ser Tyr 
                645                 650                 655     


Pro Gly Tyr Ile Pro Lys Pro Arg Gln Asp Cys Asn Ala Val Ser Thr 
            660                 665                 670         


Phe Trp Met Ala Asn Pro Asn Asn Asn Leu Ile Asn Cys Ala Ala Ala 
        675                 680                 685             


Gly Ser Glu Glu Thr Gly Phe Trp Phe Ile Phe His His Val Pro Thr 
    690                 695                 700                 


Gly Pro Ser Val Gly Met Tyr Ser Pro Gly Tyr Ser Glu His Ile Pro 
705                 710                 715                 720 


Leu Gly Lys Phe Tyr Asn Asn Arg Ala His Ser Asn Tyr Arg Ala Gly 
                725                 730                 735     


Met Ile Ile Asp Asn Gly Val Lys Thr Thr Glu Ala Ser Ala Lys Asp 
            740                 745                 750         


Lys Arg Pro Phe Leu Ser Ile Ile Ser Ala Arg Tyr Ser Pro His Gln 
        755                 760                 765             


Asp Ala Asp Pro Leu Lys Pro Arg Glu Pro Ala Ile Ile Arg His Phe 
    770                 775                 780                 


Ile Ala Tyr Lys Asn Gln Asp His Gly Ala Trp Leu Arg Gly Gly Asp 
785                 790                 795                 800 


Val Trp Leu Asp Ser Cys Arg Phe Ala Asp Asn Gly Ile Gly Leu Thr 
                805                 810                 815     


Leu Ala Ser Gly Gly Thr Phe Pro Tyr Asp Asp Gly Ser Lys Gln Glu 
            820                 825                 830         


Ile Lys Asn Ser Leu Phe Val Gly Glu Ser Gly Asn Val Gly Thr Glu 
        835                 840                 845             


Met Met Asp Asn Arg Ile Trp Gly Pro Gly Gly Leu Asp His Ser Gly 
    850                 855                 860                 


Arg Thr Leu Pro Ile Gly Gln Asn Phe Pro Ile Arg Gly Ile Gln Leu 
865                 870                 875                 880 


Tyr Asp Gly Pro Ile Asn Ile Gln Asn Cys Thr Phe Arg Lys Phe Val 
                885                 890                 895     


Ala Leu Glu Gly Arg His Thr Ser Ala Leu Ala Phe Arg Leu Asn Asn 
            900                 905                 910         


Ala Trp Gln Ser Cys Pro His Asn Asn Val Thr Gly Ile Ala Phe Glu 
        915                 920                 925             


Asp Val Pro Ile Thr Ser Arg Val Phe Phe Gly Glu Pro Gly Pro Trp 
    930                 935                 940                 


Phe Asn Gln Leu Asp Met Asp Gly Asp Lys Thr Ser Val Phe His Asp 
945                 950                 955                 960 


Val Asp Gly Ser Val Ser Glu Tyr Pro Gly Ser Tyr Leu Thr Lys Asn 
                965                 970                 975     


Asp Asn Trp Leu Val Arg His Pro Asp Cys Ile Asn Val Pro Asp Trp 
            980                 985                 990         


Arg Gly Ala Ile Cys Ser Gly Cys  Tyr Ala Gln Met Tyr  Ile Gln Ala 
        995                 1000                 1005             


Tyr Lys  Thr Ser Asn Leu Arg  Met Lys Ile Ile Lys  Asn Asp Phe 
    1010                 1015                 1020             


Pro Ser  His Pro Leu Tyr Leu  Glu Gly Ala Leu Thr  Arg Ser Thr 
    1025                 1030                 1035             


His Tyr  Gln Gln Tyr Gln Pro  Val Val Thr Leu Gln  Lys Gly Tyr 
    1040                 1045                 1050             


Thr Ile  His Trp Asp Gln Thr  Ala Pro Ala Glu Leu  Ala Ile Trp 
    1055                 1060                 1065             


Leu Ile  Asn Phe Asn Lys Gly  Asp Trp Ile Arg Val  Gly Leu Cys 
    1070                 1075                 1080             


Tyr Pro  Arg Gly Thr Thr Phe  Ser Ile Leu Ser Asp  Val His Asn 
    1085                 1090                 1095             


Arg Leu  Leu Lys Gln Thr Ser  Lys Thr Gly Val Phe  Val Arg Thr 
    1100                 1105                 1110             


Leu Gln  Met Asp Lys Val Glu  Gln Ser Tyr Pro Gly  Arg Ser His 
    1115                 1120                 1125             


Tyr Tyr  Trp Asp Glu Asp Ser  Gly Leu Leu Phe Leu  Lys Leu Lys 
    1130                 1135                 1140             


Ala Gln  Asn Glu Arg Glu Lys  Phe Ala Phe Cys Ser  Met Lys Gly 
    1145                 1150                 1155             


Cys Glu  Arg Ile Lys Ile Lys  Ala Leu Ile Pro Lys  Asn Ala Gly 
    1160                 1165                 1170             


Val Ser  Asp Cys Thr Ala Thr  Ala Tyr Pro Lys Phe  Thr Glu Arg 
    1175                 1180                 1185             


Ala Val  Val Asp Val Pro Met  Pro Lys Lys Leu Phe  Gly Ser Gln 
    1190                 1195                 1200             


Leu Lys  Thr Lys Asp His Phe  Leu Glu Val Lys Met  Glu Ser Ser 
    1205                 1210                 1215             


Lys Gln  His Phe Phe His Leu  Trp Asn Asp Phe Ala  Tyr Ile Glu 
    1220                 1225                 1230             


Val Asp  Gly Lys Lys Tyr Pro  Ser Ser Glu Asp Gly  Ile Gln Val 
    1235                 1240                 1245             


Val Val  Ile Asp Gly Asn Gln  Gly Arg Val Val Ser  His Thr Ser 
    1250                 1255                 1260             


Phe Arg  Asn Ser Ile Leu Gln  Gly Ile Pro Trp Gln  Leu Phe Asn 
    1265                 1270                 1275             


Tyr Val  Ala Thr Ile Pro Asp  Asn Ser Ile Val Leu  Met Ala Ser 
    1280                 1285                 1290             


Lys Gly  Arg Tyr Val Ser Arg  Gly Pro Trp Thr Arg  Val Leu Glu 
    1295                 1300                 1305             


Lys Leu  Gly Ala Asp Arg Gly  Leu Lys Leu Lys Glu  Gln Met Ala 
    1310                 1315                 1320             


Phe Val  Gly Phe Lys Gly Ser  Phe Arg Pro Ile Trp  Val Thr Leu 
    1325                 1330                 1335             


Asp Thr  Glu Asp His Lys Ala  Lys Ile Phe Gln Val  Val Pro Ile 
    1340                 1345                 1350             


Pro Val  Val Lys Lys Lys Lys  Leu 
    1355                 1360     

<210>  3193
<211>  4836
<212>  DNA
<213>  Homo sapiens

<400>  3193
aggggaaggg ggagggggcg ctccctcgcg caccagatta tttttggctc cgcagccggg     60

gctgctcgct gcttgtcgcg cgctcacaca cacacagaca cacacgcaca cacacacatg    120

cacacatttt ctcgcgctct ctccggctct cctttgttta ttttctaatc tatattttta    180

ctggaagatt tcctctttat tctctcccgc cctcctacaa gcgctcttgc tggccgtctg    240

ggtgcacaca ccgctccctc gatcacccca gcccccttcc tggtctcccg agcgcggggt    300

ttgaaggtca cctcctttcc agtccccgtg cgagccgcgc tgccgccgcc tcctccagcc    360

agagtcggtg ggactggctg cgctgccctg aagtggttct ccaagcagcg cggagggtgg    420

cggacggcgg acggagccca ggggccgcgt cgggtgggga aacccgaact cgcggagggg    480

aatccctccc cctccgcccc agccccccag cagcacccgc ggtggggcgg gggcgctctg    540

ccagccccgg gaacagcaga ggcggcggca ctggctggac ccacgcgcgc gcctccgggg    600

ctgaagaagg aaggagtgag ccgagccgag caccccacat ctggagggga cagccagccg    660

tgggccccgc cccggcgtcc ggagcaggag aactccgagc ttcttgccca ggcagagaga    720

gcaggagcgg accgcgcgcc cgggattgag agtccttgcg ctccagaccc ccacccagtg    780

gccgccaggg tccccgcctg tccggaccct cgccgcgccc aggcaggcgc gccagggcgg    840

ggctgacctg cccgcgaagt tgcggacagt gcgtgagaaa ccagcacccc cttccgccgc    900

ctccagctta tggtgagtgt ggctgggggt gcagagagcg cacgggaatt cgggggtctg    960

gggccgagaa cgtgaccgca gccgggctcg ccgggagttc taggaaactg gtcaaagaac   1020

tcatgcaagt ggaacttaca gcttccttga tcggactcag cattcagata tcaaagcaga   1080

ctgcaatacc tgcgtggaaa tagaagacag aaaggtttca agacaacaga tgaattgtga   1140

aagagagcag ctaaggggta atcaggaagc agccgctgcc cctgacacaa tggctcagcc   1200

ttacgcttcg gcccagtttg ctcccccgca gaacggtatc cccgcggaat acacggcccc   1260

tcatccccac cccgcgccag agtacacagg ccagaccacg gttcccgagc acacattaaa   1320

cctgtaccct cccgcccaga cgcactccga gcagagcccg gcggacacga gcgctcagac   1380

cgtctctggc accgccacac agacagatga cgcagcaccg acggatggcc agccccagac   1440

acaaccttct gaaaacacgg aaaacaagtc tcagcccaag cggctgcatg tctccaatat   1500

ccccttcagg ttccgggatc cggacctcag acaaatgttt ggtcaatttg gtaaaatctt   1560

agatgttgaa attattttta atgagcgagg ctcaaaggga tttggtttcg taactttcga   1620

aaatagtgcc gatgcggaca gggcgaggga gaaattacac ggcaccgtgg tagagggccg   1680

taaaatcgag gtaaataatg ccacagcacg tgtaatgaca aataaaaaga ccgtcaaccc   1740

ttatacaaat ggctggaaat tgaatccagt tgtgggtgca gtctacagtc ccgaattcta   1800

tgcagtgcca ggcttcccgt atccagcagc caccgccgcg gccgcctacc gaggggcgca   1860

cctgcgaggc cgcggtcgca ccgtgtacaa caccttcagg gccgcggcgc ccccgccccc   1920

gatcccggcc tacggcggtg ttgtttacca ggatggattt tatggtgcag acatttatgg   1980

tggttatgct gcataccgct acgcccagcc tacccctgcc actgccgctg cctacagtga   2040

cagttacgga cgagtttatg ctgccgaccc ctaccaccac gcacttgctc cagcccccac   2100

ctacggcgtt ggtgccatga atgcttttgc acctttgact gatgccaaga ctaggagcca   2160

tgctgatgat gtgggtctcg ttctttcttc attgcaggct agtatatacc gagggggata   2220

caaccgtttt gctccatact aaatgacaaa accataaaaa ccttccaatg tggggagaaa   2280

ggaagctttc cgaggcctga gtattgcaat acatgcagta gtacatcatt ttagcaactc   2340

taaaaaaaaa aaaaatacaa ataaaaagga aaaaaaatta cattttttat cttatacctc   2400

agatattttg ttctgtgtat tttaatattg tgggtcttta atttctgaag gttccgtagt   2460

ttggttgctg gctgtaggag tttttgtggt tgatctagac agatgctaga taatgaataa   2520

aaactggttt agggccatat ccagagtgct atattatgta aatgaattat atatgctgaa   2580

tattaagcta ctggggttat cagctatttg ggaagagtgt aagtgactac agtagtcatt   2640

tttttctgca cctgcattat tttattttgc gaaaggggag gttgggaggg gcttagggga   2700

ttggaactgg ggtttggctg aaagaaaaaa aaaaaaatgt aactgatgaa tctaaacgac   2760

ccactgcacc aacaatcatt tatcaatggt tctaagttac tcattgccag ttcaagccaa   2820

aggtcatgtt gttaaggggg tgcttctagt agcacttgtg catctgagtt gaatgaagct   2880

gtgcaaaccc accctttaaa ccattccacc cggcagtatt cagcttctta accagtcgct   2940

atttaggaaa aaaaacccac tagttaggcc atcaacaagc attcttttta tatttcttcc   3000

agtataataa attattgata tcactgctga cttttatatt atgggaggga aaaaataaca   3060

ttaataaaaa ggtgataaaa aagcactgtt tctatttttt tctttttttc caaaaaaaga   3120

aagtaataaa aacttaaatt ctttgtacca gttaaaaaaa atgtataaaa tttacatctg   3180

tgcagtggag ttgttaagtt ctagaaacag tctatgaagc tttagtttta gcctagtaga   3240

acaactgtta gagacagacg tataattttt atggaattac atgataatca tattcggatt   3300

tatagaagca ttttacaagt attgcaatca ttgagtagag ataatcatgg tattttcatc   3360

agcttggtac tttttgaaac gtgactgcgt tgtgtgaaca atctgcaatt tttcagtccg   3420

tgagatcctg cccttccacc tctttcccat acccccaagg attatctcaa aatgatctct   3480

ttagttctgt ctccaaggcc caggacactt gtcagaagga tgcaaaaaaa gaaaaaagta   3540

catccaccct cttaatccca aaagaacaaa gtctccccac ctttctcgga tgcagggcca   3600

gagtgacaca gccgaaaaat tgcagtttgt ctgtacttct gtttgaactt tccacgttgt   3660

cctgtttaca agttaactta agttggggta tccgtcacgg gtcttcctgt tttgtattta   3720

aataaaaaca acagcagcag gctgtccctg agtagttttg ctgccatagg ttaagtcctc   3780

atgtgtacag tgcaggccct gtggcccgca cttcagtaag ttatcaactc tcaccgctgt   3840

gaacctgcca atccgctgta acaactctgc tttaaaacaa aaccaaacaa aactttaaaa   3900

aaaaatgtgt gatccagctt tctcttgcca tcctatgtgc atgccgtaag atcagttgga   3960

tattaaacca tcaataaagt ttcacaagat ttgaaaacaa agtttctgta gcttcgatac   4020

ctaagacaga cgatagtgat cttgaaaaga gaaaaggggg aggggggagc tacttatcag   4080

ccaaaagcat ataaagtgtt cttttcacca gacttctttg ggtgggtgag gggaggggca   4140

agagggtgtt ttatagcatc actaagacat tctcattccc ccacctggaa aacagtgtta   4200

tggcaatggg tgcctggttg atgttcttaa aggaaacgaa ttattaaaac actatgacat   4260

cctccagagg gaagaaagag taggagcagg gggctatgga gaataaattt ctcccaattg   4320

ccgcctcaga tttcaaaatc cagaatttgt attgtgtttc gaatcacaaa catagaattc   4380

ttactgtgtt ggttaaagta aaattcattt gcagttttga ttttcatcaa tgagctgtac   4440

tttcccccat gactgtatgt agttttaata aaatcattta gagtgagtga gtgccaaccg   4500

atgttgcaga atcttttgtc taggcactcc aagatgccaa taagtcattt taaaatgtat   4560

gtcagagatg taaacaaaca ttttggattt tttttaaaca gtatttattt ggaatgtttt   4620

catttatcta aataactatt gctattatga attatggaaa attaatatta tgtgtggcat   4680

atagtgactt cttaacacac acatcacgca atctgcaaac ccagaaaatg tgtatatctg   4740

tctttagaaa ttagtgttta tatcacttac agtggtttgt gaataaagaa aactggtttg   4800

taatatcaaa aaaataaaag cttagtctga aaaggt                             4836


<210>  3194
<211>  370
<212>  PRT
<213>  Homo sapiens

<400>  3194


Met Asn Cys Glu Arg Glu Gln Leu Arg Gly Asn Gln Glu Ala Ala Ala 
1               5                   10                  15      


Ala Pro Asp Thr Met Ala Gln Pro Tyr Ala Ser Ala Gln Phe Ala Pro 
            20                  25                  30          


Pro Gln Asn Gly Ile Pro Ala Glu Tyr Thr Ala Pro His Pro His Pro 
        35                  40                  45              


Ala Pro Glu Tyr Thr Gly Gln Thr Thr Val Pro Glu His Thr Leu Asn 
    50                  55                  60                  


Leu Tyr Pro Pro Ala Gln Thr His Ser Glu Gln Ser Pro Ala Asp Thr 
65                  70                  75                  80  


Ser Ala Gln Thr Val Ser Gly Thr Ala Thr Gln Thr Asp Asp Ala Ala 
                85                  90                  95      


Pro Thr Asp Gly Gln Pro Gln Thr Gln Pro Ser Glu Asn Thr Glu Asn 
            100                 105                 110         


Lys Ser Gln Pro Lys Arg Leu His Val Ser Asn Ile Pro Phe Arg Phe 
        115                 120                 125             


Arg Asp Pro Asp Leu Arg Gln Met Phe Gly Gln Phe Gly Lys Ile Leu 
    130                 135                 140                 


Asp Val Glu Ile Ile Phe Asn Glu Arg Gly Ser Lys Gly Phe Gly Phe 
145                 150                 155                 160 


Val Thr Phe Glu Asn Ser Ala Asp Ala Asp Arg Ala Arg Glu Lys Leu 
                165                 170                 175     


His Gly Thr Val Val Glu Gly Arg Lys Ile Glu Val Asn Asn Ala Thr 
            180                 185                 190         


Ala Arg Val Met Thr Asn Lys Lys Thr Val Asn Pro Tyr Thr Asn Gly 
        195                 200                 205             


Trp Lys Leu Asn Pro Val Val Gly Ala Val Tyr Ser Pro Glu Phe Tyr 
    210                 215                 220                 


Ala Val Pro Gly Phe Pro Tyr Pro Ala Ala Thr Ala Ala Ala Ala Tyr 
225                 230                 235                 240 


Arg Gly Ala His Leu Arg Gly Arg Gly Arg Thr Val Tyr Asn Thr Phe 
                245                 250                 255     


Arg Ala Ala Ala Pro Pro Pro Pro Ile Pro Ala Tyr Gly Gly Val Val 
            260                 265                 270         


Tyr Gln Asp Gly Phe Tyr Gly Ala Asp Ile Tyr Gly Gly Tyr Ala Ala 
        275                 280                 285             


Tyr Arg Tyr Ala Gln Pro Thr Pro Ala Thr Ala Ala Ala Tyr Ser Asp 
    290                 295                 300                 


Ser Tyr Gly Arg Val Tyr Ala Ala Asp Pro Tyr His His Ala Leu Ala 
305                 310                 315                 320 


Pro Ala Pro Thr Tyr Gly Val Gly Ala Met Asn Ala Phe Ala Pro Leu 
                325                 330                 335     


Thr Asp Ala Lys Thr Arg Ser His Ala Asp Asp Val Gly Leu Val Leu 
            340                 345                 350         


Ser Ser Leu Gln Ala Ser Ile Tyr Arg Gly Gly Tyr Asn Arg Phe Ala 
        355                 360                 365             


Pro Tyr 
    370 

<210>  3195
<211>  4917
<212>  DNA
<213>  Homo sapiens

<400>  3195
aggggaaggg ggagggggcg ctccctcgcg caccagatta tttttggctc cgcagccggg     60

gctgctcgct gcttgtcgcg cgctcacaca cacacagaca cacacgcaca cacacacatg    120

cacacatttt ctcgcgctct ctccggctct cctttgttta ttttctaatc tatattttta    180

ctggaagatt tcctctttat tctctcccgc cctcctacaa gcgctcttgc tggccgtctg    240

ggtgcacaca ccgctccctc gatcacccca gcccccttcc tggtctcccg agcgcggggt    300

ttgaaggtca cctcctttcc agtccccgtg cgagccgcgc tgccgccgcc tcctccagcc    360

agagtcggtg ggactggctg cgctgccctg aagtggttct ccaagcagcg cggagggtgg    420

cggacggcgg acggagccca ggggccgcgt cgggtgggga aacccgaact cgcggagggg    480

aatccctccc cctccgcccc agccccccag cagcacccgc ggtggggcgg gggcgctctg    540

ccagccccgg gaacagcaga ggcggcggca ctggctggac ccacgcgcgc gcctccgggg    600

ctgaagaagg aaggagtgag ccgagccgag caccccacat ctggagggga cagccagccg    660

tgggccccgc cccggcgtcc ggagcaggag aactccgagc ttcttgccca ggcagagaga    720

gcaggagcgg accgcgcgcc cgggattgag agtccttgcg ctccagaccc ccacccagtg    780

gccgccaggg tccccgcctg tccggaccct cgccgcgccc aggcaggcgc gccagggcgg    840

ggctgacctg cccgcgaagt tgcggacagt gcgtgagaaa ccagcacccc cttccgccgc    900

ctccagctta tggtgagtgt ggctgggggt gcagagagcg cacgggaatt cgggggtctg    960

gggccgagaa cgtgaccgca gccgggctcg ccgggagttc taggaaactg gtcaaagaac   1020

tcatgcaagt ggaacttaca gcttccttga tcggactcag cattcagata tcaaagcaga   1080

ctgcaatacc tgcgtggaaa tagaagacag aaaggtttca agacaacaga tgaattgtga   1140

aagagagcag ctaaggggta atcaggaagc agccgctgcc cctgacacaa tggctcagcc   1200

ttacgcttcg gcccagtttg ctcccccgca gaacggtatc cccgcggaat acacggcccc   1260

tcatccccac cccgcgccag agtacacagg ccagaccacg gttcccgagc acacattaaa   1320

cctgtaccct cccgcccaga cgcactccga gcagagcccg gcggacacga gcgctcagac   1380

cgtctctggc accgccacac agacagatga cgcagcaccg acggatggcc agccccagac   1440

acaaccttct gaaaacacgg aaaacaagtc tcagcccaag cggctgcatg tctccaatat   1500

ccccttcagg ttccgggatc cggacctcag acaaatgttt ggtcaatttg gtaaaatctt   1560

agatgttgaa attattttta atgagcgagg ctcaaaggga tttggtttcg taactttcga   1620

aaatagtgcc gatgcggaca gggcgaggga gaaattacac ggcaccgtgg tagagggccg   1680

taaaatcgag gtaaataatg ccacagcacg tgtaatgaca aataaaaaga ccgtcaaccc   1740

ttatacaaat ggctggaaat tgaatccagt tgtgggtgca gtctacagtc ccgaattcta   1800

tgcaggcacg gtcctgttgt gccaggccaa ccaggaggga tcttccatgt acagtgcccc   1860

cagttcactt gtatatactt ctgcaatgcc aggcttcccg tatccagcag ccaccgccgc   1920

ggccgcctac cgaggggcgc acctgcgagg ccgcggtcgc accgtgtaca acaccttcag   1980

ggccgcggcg cccccgcccc cgatcccggc ctacggcggt gttgtttacc aggatggatt   2040

ttatggtgca gacatttatg gtggttatgc tgcataccgc tacgcccagc ctacccctgc   2100

cactgccgct gcctacagtg acagttacgg acgagtttat gctgccgacc cctaccacca   2160

cgcacttgct ccagccccca cctacggcgt tggtgccatg aatgcttttg cacctttgac   2220

tgatgccaag actaggagcc atgctgatga tgtgggtctc gttctttctt cattgcaggc   2280

tagtatatac cgagggggat acaaccgttt tgctccatac taaatgacaa aaccataaaa   2340

accttccaat gtggggagaa aggaagcttt ccgaggcctg agtattgcaa tacatgcagt   2400

agtacatcat tttagcaact ctaaaaaaaa aaaaaataca aataaaaagg aaaaaaaatt   2460

acatttttta tcttatacct cagatatttt gttctgtgta ttttaatatt gtgggtcttt   2520

aatttctgaa ggttccgtag tttggttgct ggctgtagga gtttttgtgg ttgatctaga   2580

cagatgctag ataatgaata aaaactggtt tagggccata tccagagtgc tatattatgt   2640

aaatgaatta tatatgctga atattaagct actggggtta tcagctattt gggaagagtg   2700

taagtgacta cagtagtcat ttttttctgc acctgcatta ttttattttg cgaaagggga   2760

ggttgggagg ggcttagggg attggaactg gggtttggct gaaagaaaaa aaaaaaaatg   2820

taactgatga atctaaacga cccactgcac caacaatcat ttatcaatgg ttctaagtta   2880

ctcattgcca gttcaagcca aaggtcatgt tgttaagggg gtgcttctag tagcacttgt   2940

gcatctgagt tgaatgaagc tgtgcaaacc caccctttaa accattccac ccggcagtat   3000

tcagcttctt aaccagtcgc tatttaggaa aaaaaaccca ctagttaggc catcaacaag   3060

cattcttttt atatttcttc cagtataata aattattgat atcactgctg acttttatat   3120

tatgggaggg aaaaaataac attaataaaa aggtgataaa aaagcactgt ttctattttt   3180

ttcttttttt ccaaaaaaag aaagtaataa aaacttaaat tctttgtacc agttaaaaaa   3240

aatgtataaa atttacatct gtgcagtgga gttgttaagt tctagaaaca gtctatgaag   3300

ctttagtttt agcctagtag aacaactgtt agagacagac gtataatttt tatggaatta   3360

catgataatc atattcggat ttatagaagc attttacaag tattgcaatc attgagtaga   3420

gataatcatg gtattttcat cagcttggta ctttttgaaa cgtgactgcg ttgtgtgaac   3480

aatctgcaat ttttcagtcc gtgagatcct gcccttccac ctctttccca tacccccaag   3540

gattatctca aaatgatctc tttagttctg tctccaaggc ccaggacact tgtcagaagg   3600

atgcaaaaaa agaaaaaagt acatccaccc tcttaatccc aaaagaacaa agtctcccca   3660

cctttctcgg atgcagggcc agagtgacac agccgaaaaa ttgcagtttg tctgtacttc   3720

tgtttgaact ttccacgttg tcctgtttac aagttaactt aagttggggt atccgtcacg   3780

ggtcttcctg ttttgtattt aaataaaaac aacagcagca ggctgtccct gagtagtttt   3840

gctgccatag gttaagtcct catgtgtaca gtgcaggccc tgtggcccgc acttcagtaa   3900

gttatcaact ctcaccgctg tgaacctgcc aatccgctgt aacaactctg ctttaaaaca   3960

aaaccaaaca aaactttaaa aaaaaatgtg tgatccagct ttctcttgcc atcctatgtg   4020

catgccgtaa gatcagttgg atattaaacc atcaataaag tttcacaaga tttgaaaaca   4080

aagtttctgt agcttcgata cctaagacag acgatagtga tcttgaaaag agaaaagggg   4140

gaggggggag ctacttatca gccaaaagca tataaagtgt tcttttcacc agacttcttt   4200

gggtgggtga ggggaggggc aagagggtgt tttatagcat cactaagaca ttctcattcc   4260

cccacctgga aaacagtgtt atggcaatgg gtgcctggtt gatgttctta aaggaaacga   4320

attattaaaa cactatgaca tcctccagag ggaagaaaga gtaggagcag ggggctatgg   4380

agaataaatt tctcccaatt gccgcctcag atttcaaaat ccagaatttg tattgtgttt   4440

cgaatcacaa acatagaatt cttactgtgt tggttaaagt aaaattcatt tgcagttttg   4500

attttcatca atgagctgta ctttccccca tgactgtatg tagttttaat aaaatcattt   4560

agagtgagtg agtgccaacc gatgttgcag aatcttttgt ctaggcactc caagatgcca   4620

ataagtcatt ttaaaatgta tgtcagagat gtaaacaaac attttggatt ttttttaaac   4680

agtatttatt tggaatgttt tcatttatct aaataactat tgctattatg aattatggaa   4740

aattaatatt atgtgtggca tatagtgact tcttaacaca cacatcacgc aatctgcaaa   4800

cccagaaaat gtgtatatct gtctttagaa attagtgttt atatcactta cagtggtttg   4860

tgaataaaga aaactggttt gtaatatcaa aaaaataaaa gcttagtctg aaaaggt      4917


<210>  3196
<211>  397
<212>  PRT
<213>  Homo sapiens

<400>  3196


Met Asn Cys Glu Arg Glu Gln Leu Arg Gly Asn Gln Glu Ala Ala Ala 
1               5                   10                  15      


Ala Pro Asp Thr Met Ala Gln Pro Tyr Ala Ser Ala Gln Phe Ala Pro 
            20                  25                  30          


Pro Gln Asn Gly Ile Pro Ala Glu Tyr Thr Ala Pro His Pro His Pro 
        35                  40                  45              


Ala Pro Glu Tyr Thr Gly Gln Thr Thr Val Pro Glu His Thr Leu Asn 
    50                  55                  60                  


Leu Tyr Pro Pro Ala Gln Thr His Ser Glu Gln Ser Pro Ala Asp Thr 
65                  70                  75                  80  


Ser Ala Gln Thr Val Ser Gly Thr Ala Thr Gln Thr Asp Asp Ala Ala 
                85                  90                  95      


Pro Thr Asp Gly Gln Pro Gln Thr Gln Pro Ser Glu Asn Thr Glu Asn 
            100                 105                 110         


Lys Ser Gln Pro Lys Arg Leu His Val Ser Asn Ile Pro Phe Arg Phe 
        115                 120                 125             


Arg Asp Pro Asp Leu Arg Gln Met Phe Gly Gln Phe Gly Lys Ile Leu 
    130                 135                 140                 


Asp Val Glu Ile Ile Phe Asn Glu Arg Gly Ser Lys Gly Phe Gly Phe 
145                 150                 155                 160 


Val Thr Phe Glu Asn Ser Ala Asp Ala Asp Arg Ala Arg Glu Lys Leu 
                165                 170                 175     


His Gly Thr Val Val Glu Gly Arg Lys Ile Glu Val Asn Asn Ala Thr 
            180                 185                 190         


Ala Arg Val Met Thr Asn Lys Lys Thr Val Asn Pro Tyr Thr Asn Gly 
        195                 200                 205             


Trp Lys Leu Asn Pro Val Val Gly Ala Val Tyr Ser Pro Glu Phe Tyr 
    210                 215                 220                 


Ala Gly Thr Val Leu Leu Cys Gln Ala Asn Gln Glu Gly Ser Ser Met 
225                 230                 235                 240 


Tyr Ser Ala Pro Ser Ser Leu Val Tyr Thr Ser Ala Met Pro Gly Phe 
                245                 250                 255     


Pro Tyr Pro Ala Ala Thr Ala Ala Ala Ala Tyr Arg Gly Ala His Leu 
            260                 265                 270         


Arg Gly Arg Gly Arg Thr Val Tyr Asn Thr Phe Arg Ala Ala Ala Pro 
        275                 280                 285             


Pro Pro Pro Ile Pro Ala Tyr Gly Gly Val Val Tyr Gln Asp Gly Phe 
    290                 295                 300                 


Tyr Gly Ala Asp Ile Tyr Gly Gly Tyr Ala Ala Tyr Arg Tyr Ala Gln 
305                 310                 315                 320 


Pro Thr Pro Ala Thr Ala Ala Ala Tyr Ser Asp Ser Tyr Gly Arg Val 
                325                 330                 335     


Tyr Ala Ala Asp Pro Tyr His His Ala Leu Ala Pro Ala Pro Thr Tyr 
            340                 345                 350         


Gly Val Gly Ala Met Asn Ala Phe Ala Pro Leu Thr Asp Ala Lys Thr 
        355                 360                 365             


Arg Ser His Ala Asp Asp Val Gly Leu Val Leu Ser Ser Leu Gln Ala 
    370                 375                 380                 


Ser Ile Tyr Arg Gly Gly Tyr Asn Arg Phe Ala Pro Tyr 
385                 390                 395         

<210>  3197
<211>  4008
<212>  DNA
<213>  Homo sapiens

<400>  3197
gtgcatttgt gttgtggggg catggggtgc atttgtgtgt atatatgtgt ggatgtaggg     60

tgcgtttgtc tgtgtgtatt tgtgtgggca tggagtgcat ttgcgttgcg ggggtgtgga    120

gtgtgtttgt gtgtgtgcac acgcacatgg ttctcatggt cctcccgttt tcaactgaac    180

ctgtaattag ctcctcagag accaggtttc aagacaacag atgaattgtg aaagagagca    240

gctaaggggt aatcaggaag cagccgctgc ccctgacaca atggctcagc cttacgcttc    300

ggcccagttt gctcccccgc agaacggtat ccccgcggaa tacacggccc ctcatcccca    360

ccccgcgcca gagtacacag gccagaccac ggttcccgag cacacattaa acctgtaccc    420

tcccgcccag acgcactccg agcagagccc ggcggacacg agcgctcaga ccgtctctgg    480

caccgccaca cagacagatg acgcagcacc gacggatggc cagccccaga cacaaccttc    540

tgaaaacacg gaaaacaagt ctcagcccaa gcggctgcat gtctccaata tccccttcag    600

gttccgggat ccggacctca gacaaatgtt tggtcaattt ggtaaaatct tagatgttga    660

aattattttt aatgagcgag gctcaaaggg atttggtttc gtaactttcg aaaatagtgc    720

cgatgcggac agggcgaggg agaaattaca cggcaccgtg gtagagggcc gtaaaatcga    780

ggtaaataat gccacagcac gtgtaatgac aaataaaaag accgtcaacc cttatacaaa    840

tggctggaaa ttgaatccag ttgtgggtgc agtctacagt cccgaattct atgcaggcac    900

ggtcctgttg tgccaggcca accaggaggg atcttccatg tacagtgccc ccagttcact    960

tgtatatact tctgcaatgc caggcttccc gtatccagca gccaccgccg cggccgccta   1020

ccgaggggcg cacctgcgag gccgcggtcg caccgtgtac aacaccttca gggccgcggc   1080

gcccccgccc ccgatcccgg cctacggcgg tgttgtttac caggatggat tttatggtgc   1140

agacatttat ggtggttatg ctgcataccg ctacgcccag cctacccctg ccactgccgc   1200

tgcctacagt gacagttacg gacgagttta tgctgccgac ccctaccacc acgcacttgc   1260

tccagccccc acctacggcg ttggtgccat gaatgctttt gcacctttga ctgatgccaa   1320

gactaggagc catgctgatg atgtgggtct cgttctttct tcattgcagg ctagtatata   1380

ccgaggggga tacaaccgtt ttgctccata ctaaatgaca aaaccataaa aaccttccaa   1440

tgtggggaga aaggaagctt tccgaggcct gagtattgca atacatgcag tagtacatca   1500

ttttagcaac tctaaaaaaa aaaaaaatac aaataaaaag gaaaaaaaat tacatttttt   1560

atcttatacc tcagatattt tgttctgtgt attttaatat tgtgggtctt taatttctga   1620

aggttccgta gtttggttgc tggctgtagg agtttttgtg gttgatctag acagatgcta   1680

gataatgaat aaaaactggt ttagggccat atccagagtg ctatattatg taaatgaatt   1740

atatatgctg aatattaagc tactggggtt atcagctatt tgggaagagt gtaagtgact   1800

acagtagtca tttttttctg cacctgcatt attttatttt gcgaaagggg aggttgggag   1860

gggcttaggg gattggaact ggggtttggc tgaaagaaaa aaaaaaaaat gtaactgatg   1920

aatctaaacg acccactgca ccaacaatca tttatcaatg gttctaagtt actcattgcc   1980

agttcaagcc aaaggtcatg ttgttaaggg ggtgcttcta gtagcacttg tgcatctgag   2040

ttgaatgaag ctgtgcaaac ccacccttta aaccattcca cccggcagta ttcagcttct   2100

taaccagtcg ctatttagga aaaaaaaccc actagttagg ccatcaacaa gcattctttt   2160

tatatttctt ccagtataat aaattattga tatcactgct gacttttata ttatgggagg   2220

gaaaaaataa cattaataaa aaggtgataa aaaagcactg tttctatttt tttctttttt   2280

tccaaaaaaa gaaagtaata aaaacttaaa ttctttgtac cagttaaaaa aaatgtataa   2340

aatttacatc tgtgcagtgg agttgttaag ttctagaaac agtctatgaa gctttagttt   2400

tagcctagta gaacaactgt tagagacaga cgtataattt ttatggaatt acatgataat   2460

catattcgga tttatagaag cattttacaa gtattgcaat cattgagtag agataatcat   2520

ggtattttca tcagcttggt actttttgaa acgtgactgc gttgtgtgaa caatctgcaa   2580

tttttcagtc cgtgagatcc tgcccttcca cctctttccc atacccccaa ggattatctc   2640

aaaatgatct ctttagttct gtctccaagg cccaggacac ttgtcagaag gatgcaaaaa   2700

aagaaaaaag tacatccacc ctcttaatcc caaaagaaca aagtctcccc acctttctcg   2760

gatgcagggc cagagtgaca cagccgaaaa attgcagttt gtctgtactt ctgtttgaac   2820

tttccacgtt gtcctgttta caagttaact taagttgggg tatccgtcac gggtcttcct   2880

gttttgtatt taaataaaaa caacagcagc aggctgtccc tgagtagttt tgctgccata   2940

ggttaagtcc tcatgtgtac agtgcaggcc ctgtggcccg cacttcagta agttatcaac   3000

tctcaccgct gtgaacctgc caatccgctg taacaactct gctttaaaac aaaaccaaac   3060

aaaactttaa aaaaaaatgt gtgatccagc tttctcttgc catcctatgt gcatgccgta   3120

agatcagttg gatattaaac catcaataaa gtttcacaag atttgaaaac aaagtttctg   3180

tagcttcgat acctaagaca gacgatagtg atcttgaaaa gagaaaaggg ggagggggga   3240

gctacttatc agccaaaagc atataaagtg ttcttttcac cagacttctt tgggtgggtg   3300

aggggagggg caagagggtg ttttatagca tcactaagac attctcattc ccccacctgg   3360

aaaacagtgt tatggcaatg ggtgcctggt tgatgttctt aaaggaaacg aattattaaa   3420

acactatgac atcctccaga gggaagaaag agtaggagca gggggctatg gagaataaat   3480

ttctcccaat tgccgcctca gatttcaaaa tccagaattt gtattgtgtt tcgaatcaca   3540

aacatagaat tcttactgtg ttggttaaag taaaattcat ttgcagtttt gattttcatc   3600

aatgagctgt actttccccc atgactgtat gtagttttaa taaaatcatt tagagtgagt   3660

gagtgccaac cgatgttgca gaatcttttg tctaggcact ccaagatgcc aataagtcat   3720

tttaaaatgt atgtcagaga tgtaaacaaa cattttggat tttttttaaa cagtatttat   3780

ttggaatgtt ttcatttatc taaataacta ttgctattat gaattatgga aaattaatat   3840

tatgtgtggc atatagtgac ttcttaacac acacatcacg caatctgcaa acccagaaaa   3900

tgtgtatatc tgtctttaga aattagtgtt tatatcactt acagtggttt gtgaataaag   3960

aaaactggtt tgtaatatca aaaaaataaa agcttagtct gaaaaggt                4008


<210>  3198
<211>  397
<212>  PRT
<213>  Homo sapiens

<400>  3198


Met Asn Cys Glu Arg Glu Gln Leu Arg Gly Asn Gln Glu Ala Ala Ala 
1               5                   10                  15      


Ala Pro Asp Thr Met Ala Gln Pro Tyr Ala Ser Ala Gln Phe Ala Pro 
            20                  25                  30          


Pro Gln Asn Gly Ile Pro Ala Glu Tyr Thr Ala Pro His Pro His Pro 
        35                  40                  45              


Ala Pro Glu Tyr Thr Gly Gln Thr Thr Val Pro Glu His Thr Leu Asn 
    50                  55                  60                  


Leu Tyr Pro Pro Ala Gln Thr His Ser Glu Gln Ser Pro Ala Asp Thr 
65                  70                  75                  80  


Ser Ala Gln Thr Val Ser Gly Thr Ala Thr Gln Thr Asp Asp Ala Ala 
                85                  90                  95      


Pro Thr Asp Gly Gln Pro Gln Thr Gln Pro Ser Glu Asn Thr Glu Asn 
            100                 105                 110         


Lys Ser Gln Pro Lys Arg Leu His Val Ser Asn Ile Pro Phe Arg Phe 
        115                 120                 125             


Arg Asp Pro Asp Leu Arg Gln Met Phe Gly Gln Phe Gly Lys Ile Leu 
    130                 135                 140                 


Asp Val Glu Ile Ile Phe Asn Glu Arg Gly Ser Lys Gly Phe Gly Phe 
145                 150                 155                 160 


Val Thr Phe Glu Asn Ser Ala Asp Ala Asp Arg Ala Arg Glu Lys Leu 
                165                 170                 175     


His Gly Thr Val Val Glu Gly Arg Lys Ile Glu Val Asn Asn Ala Thr 
            180                 185                 190         


Ala Arg Val Met Thr Asn Lys Lys Thr Val Asn Pro Tyr Thr Asn Gly 
        195                 200                 205             


Trp Lys Leu Asn Pro Val Val Gly Ala Val Tyr Ser Pro Glu Phe Tyr 
    210                 215                 220                 


Ala Gly Thr Val Leu Leu Cys Gln Ala Asn Gln Glu Gly Ser Ser Met 
225                 230                 235                 240 


Tyr Ser Ala Pro Ser Ser Leu Val Tyr Thr Ser Ala Met Pro Gly Phe 
                245                 250                 255     


Pro Tyr Pro Ala Ala Thr Ala Ala Ala Ala Tyr Arg Gly Ala His Leu 
            260                 265                 270         


Arg Gly Arg Gly Arg Thr Val Tyr Asn Thr Phe Arg Ala Ala Ala Pro 
        275                 280                 285             


Pro Pro Pro Ile Pro Ala Tyr Gly Gly Val Val Tyr Gln Asp Gly Phe 
    290                 295                 300                 


Tyr Gly Ala Asp Ile Tyr Gly Gly Tyr Ala Ala Tyr Arg Tyr Ala Gln 
305                 310                 315                 320 


Pro Thr Pro Ala Thr Ala Ala Ala Tyr Ser Asp Ser Tyr Gly Arg Val 
                325                 330                 335     


Tyr Ala Ala Asp Pro Tyr His His Ala Leu Ala Pro Ala Pro Thr Tyr 
            340                 345                 350         


Gly Val Gly Ala Met Asn Ala Phe Ala Pro Leu Thr Asp Ala Lys Thr 
        355                 360                 365             


Arg Ser His Ala Asp Asp Val Gly Leu Val Leu Ser Ser Leu Gln Ala 
    370                 375                 380                 


Ser Ile Tyr Arg Gly Gly Tyr Asn Arg Phe Ala Pro Tyr 
385                 390                 395         

<210>  3199
<211>  4103
<212>  DNA
<213>  Homo sapiens

<400>  3199
accttccatt ttggtagctt caactttgca gctgctgtgt ctcttcgtcg tctgggaaga     60

aaactttcac attaagagtt gctgatgcgg attttctttc tttcctctcc cggcgttgat    120

gagtgcttgg ctcctgacag aagggatttg gctcccagct ttgtagttcg gaagaagttg    180

ggtctataga tttcccccta actctccatt gatgtgttga gcttcagagg gaataataac    240

tctacgtaaa gcatgctggc gtctcaagga gttctcctgc atccttatgg cgtgcctatg    300

attgtaccgg cagctcctta ccttcctgga ctgattcagg gtaatcagga agcagccgct    360

gcccctgaca caatggctca gccttacgct tcggcccagt ttgctccccc gcagaacggt    420

atccccgcgg aatacacggc ccctcatccc caccccgcgc cagagtacac aggccagacc    480

acggttcccg agcacacatt aaacctgtac cctcccgccc agacgcactc cgagcagagc    540

ccggcggaca cgagcgctca gaccgtctct ggcaccgcca cacagacaga tgacgcagca    600

ccgacggatg gccagcccca gacacaacct tctgaaaaca cggaaaacaa gtctcagccc    660

aagcggctgc atgtctccaa tatccccttc aggttccggg atccggacct cagacaaatg    720

tttggtcaat ttggtaaaat cttagatgtt gaaattattt ttaatgagcg aggctcaaag    780

ggatttggtt tcgtaacttt cgaaaatagt gccgatgcgg acagggcgag ggagaaatta    840

cacggcaccg tggtagaggg ccgtaaaatc gaggtaaata atgccacagc acgtgtaatg    900

acaaataaaa agaccgtcaa cccttataca aatggctgga aattgaatcc agttgtgggt    960

gcagtctaca gtcccgaatt ctatgcaggc acggtcctgt tgtgccaggc caaccaggag   1020

ggatcttcca tgtacagtgc ccccagttca cttgtatata cttctgcaat gccaggcttc   1080

ccgtatccag cagccaccgc cgcggccgcc taccgagggg cgcacctgcg aggccgcggt   1140

cgcaccgtgt acaacacctt cagggccgcg gcgcccccgc ccccgatccc ggcctacggc   1200

ggagtagtgt atcaagagcc tgtgtatggc aataaattgc tgcagggtgg ttatgctgca   1260

taccgctacg cccagcctac ccctgccact gccgctgcct acagtgacag ttacggacga   1320

gtttatgctg ccgaccccta ccaccacgca cttgctccag cccccaccta cggcgttggt   1380

gccatgaatg cttttgcacc tttgactgat gccaagacta ggagccatgc tgatgatgtg   1440

ggtctcgttc tttcttcatt gcaggctagt atataccgag ggggatacaa ccgttttgct   1500

ccatactaaa tgacaaaacc ataaaaacct tccaatgtgg ggagaaagga agctttccga   1560

ggcctgagta ttgcaataca tgcagtagta catcatttta gcaactctaa aaaaaaaaaa   1620

aatacaaata aaaaggaaaa aaaattacat tttttatctt atacctcaga tattttgttc   1680

tgtgtatttt aatattgtgg gtctttaatt tctgaaggtt ccgtagtttg gttgctggct   1740

gtaggagttt ttgtggttga tctagacaga tgctagataa tgaataaaaa ctggtttagg   1800

gccatatcca gagtgctata ttatgtaaat gaattatata tgctgaatat taagctactg   1860

gggttatcag ctatttggga agagtgtaag tgactacagt agtcattttt ttctgcacct   1920

gcattatttt attttgcgaa aggggaggtt gggaggggct taggggattg gaactggggt   1980

ttggctgaaa gaaaaaaaaa aaaatgtaac tgatgaatct aaacgaccca ctgcaccaac   2040

aatcatttat caatggttct aagttactca ttgccagttc aagccaaagg tcatgttgtt   2100

aagggggtgc ttctagtagc acttgtgcat ctgagttgaa tgaagctgtg caaacccacc   2160

ctttaaacca ttccacccgg cagtattcag cttcttaacc agtcgctatt taggaaaaaa   2220

aacccactag ttaggccatc aacaagcatt ctttttatat ttcttccagt ataataaatt   2280

attgatatca ctgctgactt ttatattatg ggagggaaaa aataacatta ataaaaaggt   2340

gataaaaaag cactgtttct atttttttct ttttttccaa aaaaagaaag taataaaaac   2400

ttaaattctt tgtaccagtt aaaaaaaatg tataaaattt acatctgtgc agtggagttg   2460

ttaagttcta gaaacagtct atgaagcttt agttttagcc tagtagaaca actgttagag   2520

acagacgtat aatttttatg gaattacatg ataatcatat tcggatttat agaagcattt   2580

tacaagtatt gcaatcattg agtagagata atcatggtat tttcatcagc ttggtacttt   2640

ttgaaacgtg actgcgttgt gtgaacaatc tgcaattttt cagtccgtga gatcctgccc   2700

ttccacctct ttcccatacc cccaaggatt atctcaaaat gatctcttta gttctgtctc   2760

caaggcccag gacacttgtc agaaggatgc aaaaaaagaa aaaagtacat ccaccctctt   2820

aatcccaaaa gaacaaagtc tccccacctt tctcggatgc agggccagag tgacacagcc   2880

gaaaaattgc agtttgtctg tacttctgtt tgaactttcc acgttgtcct gtttacaagt   2940

taacttaagt tggggtatcc gtcacgggtc ttcctgtttt gtatttaaat aaaaacaaca   3000

gcagcaggct gtccctgagt agttttgctg ccataggtta agtcctcatg tgtacagtgc   3060

aggccctgtg gcccgcactt cagtaagtta tcaactctca ccgctgtgaa cctgccaatc   3120

cgctgtaaca actctgcttt aaaacaaaac caaacaaaac tttaaaaaaa aatgtgtgat   3180

ccagctttct cttgccatcc tatgtgcatg ccgtaagatc agttggatat taaaccatca   3240

ataaagtttc acaagatttg aaaacaaagt ttctgtagct tcgataccta agacagacga   3300

tagtgatctt gaaaagagaa aagggggagg ggggagctac ttatcagcca aaagcatata   3360

aagtgttctt ttcaccagac ttctttgggt gggtgagggg aggggcaaga gggtgtttta   3420

tagcatcact aagacattct cattccccca cctggaaaac agtgttatgg caatgggtgc   3480

ctggttgatg ttcttaaagg aaacgaatta ttaaaacact atgacatcct ccagagggaa   3540

gaaagagtag gagcaggggg ctatggagaa taaatttctc ccaattgccg cctcagattt   3600

caaaatccag aatttgtatt gtgtttcgaa tcacaaacat agaattctta ctgtgttggt   3660

taaagtaaaa ttcatttgca gttttgattt tcatcaatga gctgtacttt cccccatgac   3720

tgtatgtagt tttaataaaa tcatttagag tgagtgagtg ccaaccgatg ttgcagaatc   3780

ttttgtctag gcactccaag atgccaataa gtcattttaa aatgtatgtc agagatgtaa   3840

acaaacattt tggatttttt ttaaacagta tttatttgga atgttttcat ttatctaaat   3900

aactattgct attatgaatt atggaaaatt aatattatgt gtggcatata gtgacttctt   3960

aacacacaca tcacgcaatc tgcaaaccca gaaaatgtgt atatctgtct ttagaaatta   4020

gtgtttatat cacttacagt ggtttgtgaa taaagaaaac tggtttgtaa tatcaaaaaa   4080

ataaaagctt agtctgaaaa ggt                                           4103


<210>  3200
<211>  418
<212>  PRT
<213>  Homo sapiens

<400>  3200


Met Leu Ala Ser Gln Gly Val Leu Leu His Pro Tyr Gly Val Pro Met 
1               5                   10                  15      


Ile Val Pro Ala Ala Pro Tyr Leu Pro Gly Leu Ile Gln Gly Asn Gln 
            20                  25                  30          


Glu Ala Ala Ala Ala Pro Asp Thr Met Ala Gln Pro Tyr Ala Ser Ala 
        35                  40                  45              


Gln Phe Ala Pro Pro Gln Asn Gly Ile Pro Ala Glu Tyr Thr Ala Pro 
    50                  55                  60                  


His Pro His Pro Ala Pro Glu Tyr Thr Gly Gln Thr Thr Val Pro Glu 
65                  70                  75                  80  


His Thr Leu Asn Leu Tyr Pro Pro Ala Gln Thr His Ser Glu Gln Ser 
                85                  90                  95      


Pro Ala Asp Thr Ser Ala Gln Thr Val Ser Gly Thr Ala Thr Gln Thr 
            100                 105                 110         


Asp Asp Ala Ala Pro Thr Asp Gly Gln Pro Gln Thr Gln Pro Ser Glu 
        115                 120                 125             


Asn Thr Glu Asn Lys Ser Gln Pro Lys Arg Leu His Val Ser Asn Ile 
    130                 135                 140                 


Pro Phe Arg Phe Arg Asp Pro Asp Leu Arg Gln Met Phe Gly Gln Phe 
145                 150                 155                 160 


Gly Lys Ile Leu Asp Val Glu Ile Ile Phe Asn Glu Arg Gly Ser Lys 
                165                 170                 175     


Gly Phe Gly Phe Val Thr Phe Glu Asn Ser Ala Asp Ala Asp Arg Ala 
            180                 185                 190         


Arg Glu Lys Leu His Gly Thr Val Val Glu Gly Arg Lys Ile Glu Val 
        195                 200                 205             


Asn Asn Ala Thr Ala Arg Val Met Thr Asn Lys Lys Thr Val Asn Pro 
    210                 215                 220                 


Tyr Thr Asn Gly Trp Lys Leu Asn Pro Val Val Gly Ala Val Tyr Ser 
225                 230                 235                 240 


Pro Glu Phe Tyr Ala Gly Thr Val Leu Leu Cys Gln Ala Asn Gln Glu 
                245                 250                 255     


Gly Ser Ser Met Tyr Ser Ala Pro Ser Ser Leu Val Tyr Thr Ser Ala 
            260                 265                 270         


Met Pro Gly Phe Pro Tyr Pro Ala Ala Thr Ala Ala Ala Ala Tyr Arg 
        275                 280                 285             


Gly Ala His Leu Arg Gly Arg Gly Arg Thr Val Tyr Asn Thr Phe Arg 
    290                 295                 300                 


Ala Ala Ala Pro Pro Pro Pro Ile Pro Ala Tyr Gly Gly Val Val Tyr 
305                 310                 315                 320 


Gln Glu Pro Val Tyr Gly Asn Lys Leu Leu Gln Gly Gly Tyr Ala Ala 
                325                 330                 335     


Tyr Arg Tyr Ala Gln Pro Thr Pro Ala Thr Ala Ala Ala Tyr Ser Asp 
            340                 345                 350         


Ser Tyr Gly Arg Val Tyr Ala Ala Asp Pro Tyr His His Ala Leu Ala 
        355                 360                 365             


Pro Ala Pro Thr Tyr Gly Val Gly Ala Met Asn Ala Phe Ala Pro Leu 
    370                 375                 380                 


Thr Asp Ala Lys Thr Arg Ser His Ala Asp Asp Val Gly Leu Val Leu 
385                 390                 395                 400 


Ser Ser Leu Gln Ala Ser Ile Tyr Arg Gly Gly Tyr Asn Arg Phe Ala 
                405                 410                 415     


Pro Tyr 
        

<210>  3201
<211>  4025
<212>  DNA
<213>  Homo sapiens

<400>  3201
accttccatt ttggtagctt caactttgca gctgctgtgt ctcttcgtcg tctgggaaga     60

aaactttcac attaagagtt gctgatgcgg attttctttc tttcctctcc cggcgttgat    120

gagtgcttgg ctcctgacag aagggatttg gctcccagct ttgtagttcg gaagaagttg    180

ggtctataga tttcccccta actctccatt gatgtgttga gcttcagagg gaataataac    240

tctacgtaaa gcatgctggc gtctcaagga gttctcctgc atccttatgg cgtgcctatg    300

attgtaccgg cagctcctta ccttcctgga ctgattcagg gtaatcagga agcagccgct    360

gcccctgaca caatggctca gccttacgct tcggcccagt ttgctccccc gcagaacggt    420

atccccgcgg aatacacggc ccctcatccc caccccgcgc cagagtacac aggccagacc    480

acggttcccg agcacacatt aaacctgtac cctcccgccc agacgcactc cgagcagagc    540

ccggcggaca cgagcgctca gaccgtctct ggcaccgcca cacagacaga tgacgcagca    600

ccgacggatg gccagcccca gacacaacct tctgaaaaca cggaaaacaa gtctcagccc    660

aagcggctgc atgtctccaa tatccccttc aggttccggg atccggacct cagacaaatg    720

tttggtcaat ttggtaaaat cttagatgtt gaaattattt ttaatgagcg aggctcaaag    780

ggatttggtt tcgtaacttt cgaaaatagt gccgatgcgg acagggcgag ggagaaatta    840

cacggcaccg tggtagaggg ccgtaaaatc gaggtaaata atgccacagc acgtgtaatg    900

acaaataaaa agaccgtcaa cccttataca aatggctgga aattgaatcc agttgtgggt    960

gcagtctaca gtcccgaatt ctatgcaggc acggtcctgt tgtgccaggc caaccaggag   1020

ggatcttcca tgtacagtgc ccccagttca cttgtatata cttctgcaat gccaggcttc   1080

ccgtatccag cagccaccgc cgcggccgcc taccgagggg cgcacctgcg aggccgcggt   1140

cgcaccgtgt acaacacctt cagggccgcg gcgcccccgc ccccgatccc ggcctacggc   1200

ggagtagtgt atcaagagcc tgtgtatggc aataaattgc tgcagggtgg ttatgctgca   1260

taccgctacg cccagcctac ccctgccact gccgctgcct acagtgacag ttacggacga   1320

gtttatgctg ccgaccccta ccaccacgca cttgctccag cccccaccta cggcgttggt   1380

gccatggcta gtatataccg agggggatac aaccgttttg ctccatacta aatgacaaaa   1440

ccataaaaac cttccaatgt ggggagaaag gaagctttcc gaggcctgag tattgcaata   1500

catgcagtag tacatcattt tagcaactct aaaaaaaaaa aaaatacaaa taaaaaggaa   1560

aaaaaattac attttttatc ttatacctca gatattttgt tctgtgtatt ttaatattgt   1620

gggtctttaa tttctgaagg ttccgtagtt tggttgctgg ctgtaggagt ttttgtggtt   1680

gatctagaca gatgctagat aatgaataaa aactggttta gggccatatc cagagtgcta   1740

tattatgtaa atgaattata tatgctgaat attaagctac tggggttatc agctatttgg   1800

gaagagtgta agtgactaca gtagtcattt ttttctgcac ctgcattatt ttattttgcg   1860

aaaggggagg ttgggagggg cttaggggat tggaactggg gtttggctga aagaaaaaaa   1920

aaaaaatgta actgatgaat ctaaacgacc cactgcacca acaatcattt atcaatggtt   1980

ctaagttact cattgccagt tcaagccaaa ggtcatgttg ttaagggggt gcttctagta   2040

gcacttgtgc atctgagttg aatgaagctg tgcaaaccca ccctttaaac cattccaccc   2100

ggcagtattc agcttcttaa ccagtcgcta tttaggaaaa aaaacccact agttaggcca   2160

tcaacaagca ttctttttat atttcttcca gtataataaa ttattgatat cactgctgac   2220

ttttatatta tgggagggaa aaaataacat taataaaaag gtgataaaaa agcactgttt   2280

ctattttttt ctttttttcc aaaaaaagaa agtaataaaa acttaaattc tttgtaccag   2340

ttaaaaaaaa tgtataaaat ttacatctgt gcagtggagt tgttaagttc tagaaacagt   2400

ctatgaagct ttagttttag cctagtagaa caactgttag agacagacgt ataattttta   2460

tggaattaca tgataatcat attcggattt atagaagcat tttacaagta ttgcaatcat   2520

tgagtagaga taatcatggt attttcatca gcttggtact ttttgaaacg tgactgcgtt   2580

gtgtgaacaa tctgcaattt ttcagtccgt gagatcctgc ccttccacct ctttcccata   2640

cccccaagga ttatctcaaa atgatctctt tagttctgtc tccaaggccc aggacacttg   2700

tcagaaggat gcaaaaaaag aaaaaagtac atccaccctc ttaatcccaa aagaacaaag   2760

tctccccacc tttctcggat gcagggccag agtgacacag ccgaaaaatt gcagtttgtc   2820

tgtacttctg tttgaacttt ccacgttgtc ctgtttacaa gttaacttaa gttggggtat   2880

ccgtcacggg tcttcctgtt ttgtatttaa ataaaaacaa cagcagcagg ctgtccctga   2940

gtagttttgc tgccataggt taagtcctca tgtgtacagt gcaggccctg tggcccgcac   3000

ttcagtaagt tatcaactct caccgctgtg aacctgccaa tccgctgtaa caactctgct   3060

ttaaaacaaa accaaacaaa actttaaaaa aaaatgtgtg atccagcttt ctcttgccat   3120

cctatgtgca tgccgtaaga tcagttggat attaaaccat caataaagtt tcacaagatt   3180

tgaaaacaaa gtttctgtag cttcgatacc taagacagac gatagtgatc ttgaaaagag   3240

aaaaggggga ggggggagct acttatcagc caaaagcata taaagtgttc ttttcaccag   3300

acttctttgg gtgggtgagg ggaggggcaa gagggtgttt tatagcatca ctaagacatt   3360

ctcattcccc cacctggaaa acagtgttat ggcaatgggt gcctggttga tgttcttaaa   3420

ggaaacgaat tattaaaaca ctatgacatc ctccagaggg aagaaagagt aggagcaggg   3480

ggctatggag aataaatttc tcccaattgc cgcctcagat ttcaaaatcc agaatttgta   3540

ttgtgtttcg aatcacaaac atagaattct tactgtgttg gttaaagtaa aattcatttg   3600

cagttttgat tttcatcaat gagctgtact ttcccccatg actgtatgta gttttaataa   3660

aatcatttag agtgagtgag tgccaaccga tgttgcagaa tcttttgtct aggcactcca   3720

agatgccaat aagtcatttt aaaatgtatg tcagagatgt aaacaaacat tttggatttt   3780

ttttaaacag tatttatttg gaatgttttc atttatctaa ataactattg ctattatgaa   3840

ttatggaaaa ttaatattat gtgtggcata tagtgacttc ttaacacaca catcacgcaa   3900

tctgcaaacc cagaaaatgt gtatatctgt ctttagaaat tagtgtttat atcacttaca   3960

gtggtttgtg aataaagaaa actggtttgt aatatcaaaa aaataaaagc ttagtctgaa   4020

aaggt                                                               4025


<210>  3202
<211>  392
<212>  PRT
<213>  Homo sapiens

<400>  3202


Met Leu Ala Ser Gln Gly Val Leu Leu His Pro Tyr Gly Val Pro Met 
1               5                   10                  15      


Ile Val Pro Ala Ala Pro Tyr Leu Pro Gly Leu Ile Gln Gly Asn Gln 
            20                  25                  30          


Glu Ala Ala Ala Ala Pro Asp Thr Met Ala Gln Pro Tyr Ala Ser Ala 
        35                  40                  45              


Gln Phe Ala Pro Pro Gln Asn Gly Ile Pro Ala Glu Tyr Thr Ala Pro 
    50                  55                  60                  


His Pro His Pro Ala Pro Glu Tyr Thr Gly Gln Thr Thr Val Pro Glu 
65                  70                  75                  80  


His Thr Leu Asn Leu Tyr Pro Pro Ala Gln Thr His Ser Glu Gln Ser 
                85                  90                  95      


Pro Ala Asp Thr Ser Ala Gln Thr Val Ser Gly Thr Ala Thr Gln Thr 
            100                 105                 110         


Asp Asp Ala Ala Pro Thr Asp Gly Gln Pro Gln Thr Gln Pro Ser Glu 
        115                 120                 125             


Asn Thr Glu Asn Lys Ser Gln Pro Lys Arg Leu His Val Ser Asn Ile 
    130                 135                 140                 


Pro Phe Arg Phe Arg Asp Pro Asp Leu Arg Gln Met Phe Gly Gln Phe 
145                 150                 155                 160 


Gly Lys Ile Leu Asp Val Glu Ile Ile Phe Asn Glu Arg Gly Ser Lys 
                165                 170                 175     


Gly Phe Gly Phe Val Thr Phe Glu Asn Ser Ala Asp Ala Asp Arg Ala 
            180                 185                 190         


Arg Glu Lys Leu His Gly Thr Val Val Glu Gly Arg Lys Ile Glu Val 
        195                 200                 205             


Asn Asn Ala Thr Ala Arg Val Met Thr Asn Lys Lys Thr Val Asn Pro 
    210                 215                 220                 


Tyr Thr Asn Gly Trp Lys Leu Asn Pro Val Val Gly Ala Val Tyr Ser 
225                 230                 235                 240 


Pro Glu Phe Tyr Ala Gly Thr Val Leu Leu Cys Gln Ala Asn Gln Glu 
                245                 250                 255     


Gly Ser Ser Met Tyr Ser Ala Pro Ser Ser Leu Val Tyr Thr Ser Ala 
            260                 265                 270         


Met Pro Gly Phe Pro Tyr Pro Ala Ala Thr Ala Ala Ala Ala Tyr Arg 
        275                 280                 285             


Gly Ala His Leu Arg Gly Arg Gly Arg Thr Val Tyr Asn Thr Phe Arg 
    290                 295                 300                 


Ala Ala Ala Pro Pro Pro Pro Ile Pro Ala Tyr Gly Gly Val Val Tyr 
305                 310                 315                 320 


Gln Glu Pro Val Tyr Gly Asn Lys Leu Leu Gln Gly Gly Tyr Ala Ala 
                325                 330                 335     


Tyr Arg Tyr Ala Gln Pro Thr Pro Ala Thr Ala Ala Ala Tyr Ser Asp 
            340                 345                 350         


Ser Tyr Gly Arg Val Tyr Ala Ala Asp Pro Tyr His His Ala Leu Ala 
        355                 360                 365             


Pro Ala Pro Thr Tyr Gly Val Gly Ala Met Ala Ser Ile Tyr Arg Gly 
    370                 375                 380                 


Gly Tyr Asn Arg Phe Ala Pro Tyr 
385                 390         

<210>  3203
<211>  4156
<212>  DNA
<213>  Homo sapiens

<400>  3203
accttccatt ttggtagctt caactttgca gctgctgtgt ctcttcgtcg tctgggaaga     60

aaactttcac attaagagtt gctgatgcgg attttctttc tttcctctcc cggcgttgat    120

gagtgcttgg ctcctgacag aagggatttg gctcccagct ttgtagttcg gaagaagttg    180

ggtctataga tttcccccta actctccatt gatgtgttga gcttcagagg gaataataac    240

tctacgtaaa gcatgctggc gtctcaagga gttctcctgc atccttatgg cgtgcctatg    300

attgtaccgg cagctcctta ccttcctgga ctgattcagg gtaatcagga agcagccgct    360

gcccctgaca caatggctca gccttacgct tcggcccagt ttgctccccc gcagaacggt    420

atccccgcgg aatacacggc ccctcatccc caccccgcgc cagagtacac aggccagacc    480

acggttcccg agcacacatt aaacctgtac cctcccgccc agacgcactc cgagcagagc    540

ccggcggaca cgagcgctca gaccgtctct ggcaccgcca cacagacaga tgacgcagca    600

ccgacggatg gccagcccca gacacaacct tctgaaaaca cggaaaacaa gtctcagccc    660

aagcggctgc atgtctccaa tatccccttc aggttccggg atccggacct cagacaaatg    720

tttggtcaat ttggtaaaat cttagatgtt gaaattattt ttaatgagcg aggctcaaag    780

ggatttggtt tcgtaacttt cgaaaatagt gccgatgcgg acagggcgag ggagaaatta    840

cacggcaccg tggtagaggg ccgtaaaatc gaggtaaata atgccacagc acgtgtaatg    900

acaaataaaa agaccgtcaa cccttataca aatggctgga aattgaatcc agttgtgggt    960

gcagtctaca gtcccgaatt ctatgcaggc acggtcctgt tgtgccaggc caaccaggag   1020

ggatcttcca tgtacagtgc ccccagttca cttgtatata cttctgcaat gccaggcttc   1080

ccgtatccag cagccaccgc cgcggccgcc taccgagggg cgcacctgcg aggccgcggt   1140

cgcaccgtgt acaacacctt cagggccgcg gcgcccccgc ccccgatccc ggcctacggc   1200

ggagtagtgt atcaagagcc tgtgtatggc aataaattgc tgcagggtgg ttatgctgca   1260

taccgctacg cccagcctac ccctgccact gccgctgcct acagtgacag aaatcagttc   1320

gtcttcgttg cagcagatga aatttcttgt aacacctctg cagttacgga cgagtttatg   1380

ctgccgaccc ctaccaccac gcacttgctc cagcccccac ctacggcgtt ggtgccatga   1440

atgcttttgc acctttgact gatgccaaga ctaggagcca tgctgatgat gtgggtctcg   1500

ttctttcttc attgcaggct agtatatacc gagggggata caaccgtttt gctccatact   1560

aaatgacaaa accataaaaa ccttccaatg tggggagaaa ggaagctttc cgaggcctga   1620

gtattgcaat acatgcagta gtacatcatt ttagcaactc taaaaaaaaa aaaaatacaa   1680

ataaaaagga aaaaaaatta cattttttat cttatacctc agatattttg ttctgtgtat   1740

tttaatattg tgggtcttta atttctgaag gttccgtagt ttggttgctg gctgtaggag   1800

tttttgtggt tgatctagac agatgctaga taatgaataa aaactggttt agggccatat   1860

ccagagtgct atattatgta aatgaattat atatgctgaa tattaagcta ctggggttat   1920

cagctatttg ggaagagtgt aagtgactac agtagtcatt tttttctgca cctgcattat   1980

tttattttgc gaaaggggag gttgggaggg gcttagggga ttggaactgg ggtttggctg   2040

aaagaaaaaa aaaaaaatgt aactgatgaa tctaaacgac ccactgcacc aacaatcatt   2100

tatcaatggt tctaagttac tcattgccag ttcaagccaa aggtcatgtt gttaaggggg   2160

tgcttctagt agcacttgtg catctgagtt gaatgaagct gtgcaaaccc accctttaaa   2220

ccattccacc cggcagtatt cagcttctta accagtcgct atttaggaaa aaaaacccac   2280

tagttaggcc atcaacaagc attcttttta tatttcttcc agtataataa attattgata   2340

tcactgctga cttttatatt atgggaggga aaaaataaca ttaataaaaa ggtgataaaa   2400

aagcactgtt tctatttttt tctttttttc caaaaaaaga aagtaataaa aacttaaatt   2460

ctttgtacca gttaaaaaaa atgtataaaa tttacatctg tgcagtggag ttgttaagtt   2520

ctagaaacag tctatgaagc tttagtttta gcctagtaga acaactgtta gagacagacg   2580

tataattttt atggaattac atgataatca tattcggatt tatagaagca ttttacaagt   2640

attgcaatca ttgagtagag ataatcatgg tattttcatc agcttggtac tttttgaaac   2700

gtgactgcgt tgtgtgaaca atctgcaatt tttcagtccg tgagatcctg cccttccacc   2760

tctttcccat acccccaagg attatctcaa aatgatctct ttagttctgt ctccaaggcc   2820

caggacactt gtcagaagga tgcaaaaaaa gaaaaaagta catccaccct cttaatccca   2880

aaagaacaaa gtctccccac ctttctcgga tgcagggcca gagtgacaca gccgaaaaat   2940

tgcagtttgt ctgtacttct gtttgaactt tccacgttgt cctgtttaca agttaactta   3000

agttggggta tccgtcacgg gtcttcctgt tttgtattta aataaaaaca acagcagcag   3060

gctgtccctg agtagttttg ctgccatagg ttaagtcctc atgtgtacag tgcaggccct   3120

gtggcccgca cttcagtaag ttatcaactc tcaccgctgt gaacctgcca atccgctgta   3180

acaactctgc tttaaaacaa aaccaaacaa aactttaaaa aaaaatgtgt gatccagctt   3240

tctcttgcca tcctatgtgc atgccgtaag atcagttgga tattaaacca tcaataaagt   3300

ttcacaagat ttgaaaacaa agtttctgta gcttcgatac ctaagacaga cgatagtgat   3360

cttgaaaaga gaaaaggggg aggggggagc tacttatcag ccaaaagcat ataaagtgtt   3420

cttttcacca gacttctttg ggtgggtgag gggaggggca agagggtgtt ttatagcatc   3480

actaagacat tctcattccc ccacctggaa aacagtgtta tggcaatggg tgcctggttg   3540

atgttcttaa aggaaacgaa ttattaaaac actatgacat cctccagagg gaagaaagag   3600

taggagcagg gggctatgga gaataaattt ctcccaattg ccgcctcaga tttcaaaatc   3660

cagaatttgt attgtgtttc gaatcacaaa catagaattc ttactgtgtt ggttaaagta   3720

aaattcattt gcagttttga ttttcatcaa tgagctgtac tttcccccat gactgtatgt   3780

agttttaata aaatcattta gagtgagtga gtgccaaccg atgttgcaga atcttttgtc   3840

taggcactcc aagatgccaa taagtcattt taaaatgtat gtcagagatg taaacaaaca   3900

ttttggattt tttttaaaca gtatttattt ggaatgtttt catttatcta aataactatt   3960

gctattatga attatggaaa attaatatta tgtgtggcat atagtgactt cttaacacac   4020

acatcacgca atctgcaaac ccagaaaatg tgtatatctg tctttagaaa ttagtgttta   4080

tatcacttac agtggtttgt gaataaagaa aactggtttg taatatcaaa aaaataaaag   4140

cttagtctga aaaggt                                                   4156


<210>  3204
<211>  395
<212>  PRT
<213>  Homo sapiens

<400>  3204


Met Leu Ala Ser Gln Gly Val Leu Leu His Pro Tyr Gly Val Pro Met 
1               5                   10                  15      


Ile Val Pro Ala Ala Pro Tyr Leu Pro Gly Leu Ile Gln Gly Asn Gln 
            20                  25                  30          


Glu Ala Ala Ala Ala Pro Asp Thr Met Ala Gln Pro Tyr Ala Ser Ala 
        35                  40                  45              


Gln Phe Ala Pro Pro Gln Asn Gly Ile Pro Ala Glu Tyr Thr Ala Pro 
    50                  55                  60                  


His Pro His Pro Ala Pro Glu Tyr Thr Gly Gln Thr Thr Val Pro Glu 
65                  70                  75                  80  


His Thr Leu Asn Leu Tyr Pro Pro Ala Gln Thr His Ser Glu Gln Ser 
                85                  90                  95      


Pro Ala Asp Thr Ser Ala Gln Thr Val Ser Gly Thr Ala Thr Gln Thr 
            100                 105                 110         


Asp Asp Ala Ala Pro Thr Asp Gly Gln Pro Gln Thr Gln Pro Ser Glu 
        115                 120                 125             


Asn Thr Glu Asn Lys Ser Gln Pro Lys Arg Leu His Val Ser Asn Ile 
    130                 135                 140                 


Pro Phe Arg Phe Arg Asp Pro Asp Leu Arg Gln Met Phe Gly Gln Phe 
145                 150                 155                 160 


Gly Lys Ile Leu Asp Val Glu Ile Ile Phe Asn Glu Arg Gly Ser Lys 
                165                 170                 175     


Gly Phe Gly Phe Val Thr Phe Glu Asn Ser Ala Asp Ala Asp Arg Ala 
            180                 185                 190         


Arg Glu Lys Leu His Gly Thr Val Val Glu Gly Arg Lys Ile Glu Val 
        195                 200                 205             


Asn Asn Ala Thr Ala Arg Val Met Thr Asn Lys Lys Thr Val Asn Pro 
    210                 215                 220                 


Tyr Thr Asn Gly Trp Lys Leu Asn Pro Val Val Gly Ala Val Tyr Ser 
225                 230                 235                 240 


Pro Glu Phe Tyr Ala Gly Thr Val Leu Leu Cys Gln Ala Asn Gln Glu 
                245                 250                 255     


Gly Ser Ser Met Tyr Ser Ala Pro Ser Ser Leu Val Tyr Thr Ser Ala 
            260                 265                 270         


Met Pro Gly Phe Pro Tyr Pro Ala Ala Thr Ala Ala Ala Ala Tyr Arg 
        275                 280                 285             


Gly Ala His Leu Arg Gly Arg Gly Arg Thr Val Tyr Asn Thr Phe Arg 
    290                 295                 300                 


Ala Ala Ala Pro Pro Pro Pro Ile Pro Ala Tyr Gly Gly Val Val Tyr 
305                 310                 315                 320 


Gln Glu Pro Val Tyr Gly Asn Lys Leu Leu Gln Gly Gly Tyr Ala Ala 
                325                 330                 335     


Tyr Arg Tyr Ala Gln Pro Thr Pro Ala Thr Ala Ala Ala Tyr Ser Asp 
            340                 345                 350         


Arg Asn Gln Phe Val Phe Val Ala Ala Asp Glu Ile Ser Cys Asn Thr 
        355                 360                 365             


Ser Ala Val Thr Asp Glu Phe Met Leu Pro Thr Pro Thr Thr Thr His 
    370                 375                 380                 


Leu Leu Gln Pro Pro Pro Thr Ala Leu Val Pro 
385                 390                 395 

<210>  3205
<211>  2718
<212>  DNA
<213>  Homo sapiens

<400>  3205
actccggctt ctgtgatgtc agcgccggaa cctggaatcc cggctccgcg agggaaggcc     60

ggggaggcgg cggcggcggc ggcggctgga gagggtcctc ggcagcctct gaggagcgcg    120

gggcgcggcc atgagcgagt ccagcggcag tgcgctccag cccggcaggc ccagccggca    180

gccggcggtc catccagaga acctctctct agactccagt tgcttctctt ctccacctgt    240

gaacttcctc caagaattgc caagctaccg gtccattgca cgtaggagaa cgactgtcca    300

ttcccgggac aagcaaagcg gaactttgct aaagccaacc gactcttaca gctcccagct    360

ggaggacaga atcgctgaaa acctcagcag ccattctctt cgaaattatg cactgaacat    420

ctctgagaag cggagactaa gggacattca agagacacaa atgaagtatc tctccgaatg    480

ggaccagtgg aagcggtata gcagcaagtc ttggaagagg ttcctagaga aggctcgaga    540

gatgacgacc cacctggagc tgtggcggga ggacatccgc agcatagaag ggaaatttgg    600

cactgggatt cagtcctatt tctccttctt gagattcctg gtgttgctga atttggtgat    660

atttctgatc atctttatgc tggttttgct cccagtctta ctcacgaaat acaagatcac    720

caacagcagc ttcgtgctca ttcctttcaa agacatggat aaacaatgta cagtctatcc    780

agtaagcagt tctggactca tttactttta cagttatatc atagacttgc tttctggcac    840

tggtttcctg gaggaaacta gcctctttta cggacattac accattgatg gggtgaaatt    900

tcagaacttc acctatgatc tgcccctggc gtatttgtta agcacaatcg cctccctggc    960

cctgagcctt ctttggatag tgaaaaggtc ggtggaagga ttcaaaatca acctgattcg   1020

gagtgaggag cactttcaga gttactgcaa caagatattt gccggctggg acttctgcat   1080

cactaaccgc agcatggcgg atctgaagca cagcagcttg cggtacgagc tccgagcaga   1140

tctggaggaa gaaagaatgc ggcagaaaat agcagaaagg acctcagaag aaacaatacg   1200

catttactct ttgagactgt ttttgaactg tattgttctg gctgttttag gggcatgctt   1260

ttatgcaata tacgtagcaa ctgtcttctc gcaagagcac atgaaaaagg aaatcgacaa   1320

gatggttttt ggagagaacc tcttcatatt gtatctaccg tctattgtga tcacgctggc   1380

caattttatc accccaatga tctttgccaa gatcatccgc tatgaggatt attctccagg   1440

ctttgagatc cgtctgacaa tccttaggtg tgtctttatg cggctggcca ccatatgtgt   1500

cctggtgttc acgctgggct ccaagatcac atcctgtgat gatgacacat gtgacctttg   1560

cggctacaac cagaaactct acccgtgctg ggagacccaa gttgggcagg aaatgtacaa   1620

gctgatgatc ttcgacttca tcatcatctt ggctgtgaca ctcttcgtgg attttcctag   1680

aaagctcctg gtgacctact gttcctcttg caagctgatt cagtgctggg ggcagcagga   1740

gtttgccatt cctgataacg tcctggggat agtttacggg caaaccatct gctggatcgg   1800

agcctttttc tcaccccttc tccctgcaat tgcaaccctg aaattcatta tcatcttcta   1860

tgtgaaagag tggagtctgc tttacacctg cagaccctcc cccaggccgt tcagagcatc   1920

caattctaat ttcttcttcc tgttggtgtt gttgatcggg ctgtgtttgg caataatacc   1980

tctgacaatc agcatatcac gcatcccttc ctcgaaagcc tgtgggccgt tcaccaactt   2040

caacaccacc tgggaggtca tccccaagac ggtgagcacc ttccccagct cgctgcagtc   2100

cttcatccat ggtgtcacat ccgaagcctt tgcagttcct ttcttcatga ttatttgcct   2160

catcatgttt tacttcattg ccttagctgg agcacacaaa cgggtggtca tccagctccg   2220

agagcagcta tccctggtaa ggaagcatag ctccagaggg tcatggctgg ggacatttac   2280

ccaggacact gcaaggaaag tgctgttttc ctgggaggga gtgaaattac tgcagccttc   2340

tctcaccacc acctccccaa aactctgcct tgaggcccag ccgcgtccag cttcattaat   2400

tcactgattc atccattcct tcaagatgtg tattaagggg gatgtggtgg ctcatgcctg   2460

taatcccagc acttttggga ggccgaggca ggcagattac ttgagctcag gagttcaaga   2520

ccagcctggc caacatggtg aaaccccgtc tctactaaaa atacaaaaag tagttgggcg   2580

tggtggtggg cacctgtaat cccagctact tgggaggctg aggcaggaga atcccttgaa   2640

ctcaggaggt ggaggtcgca gtgagctgag attgcgctat tgcactccag cctgggtgac   2700

agagtgagac tccatctt                                                 2718


<210>  3206
<211>  758
<212>  PRT
<213>  Homo sapiens

<400>  3206


Met Ser Glu Ser Ser Gly Ser Ala Leu Gln Pro Gly Arg Pro Ser Arg 
1               5                   10                  15      


Gln Pro Ala Val His Pro Glu Asn Leu Ser Leu Asp Ser Ser Cys Phe 
            20                  25                  30          


Ser Ser Pro Pro Val Asn Phe Leu Gln Glu Leu Pro Ser Tyr Arg Ser 
        35                  40                  45              


Ile Ala Arg Arg Arg Thr Thr Val His Ser Arg Asp Lys Gln Ser Gly 
    50                  55                  60                  


Thr Leu Leu Lys Pro Thr Asp Ser Tyr Ser Ser Gln Leu Glu Asp Arg 
65                  70                  75                  80  


Ile Ala Glu Asn Leu Ser Ser His Ser Leu Arg Asn Tyr Ala Leu Asn 
                85                  90                  95      


Ile Ser Glu Lys Arg Arg Leu Arg Asp Ile Gln Glu Thr Gln Met Lys 
            100                 105                 110         


Tyr Leu Ser Glu Trp Asp Gln Trp Lys Arg Tyr Ser Ser Lys Ser Trp 
        115                 120                 125             


Lys Arg Phe Leu Glu Lys Ala Arg Glu Met Thr Thr His Leu Glu Leu 
    130                 135                 140                 


Trp Arg Glu Asp Ile Arg Ser Ile Glu Gly Lys Phe Gly Thr Gly Ile 
145                 150                 155                 160 


Gln Ser Tyr Phe Ser Phe Leu Arg Phe Leu Val Leu Leu Asn Leu Val 
                165                 170                 175     


Ile Phe Leu Ile Ile Phe Met Leu Val Leu Leu Pro Val Leu Leu Thr 
            180                 185                 190         


Lys Tyr Lys Ile Thr Asn Ser Ser Phe Val Leu Ile Pro Phe Lys Asp 
        195                 200                 205             


Met Asp Lys Gln Cys Thr Val Tyr Pro Val Ser Ser Ser Gly Leu Ile 
    210                 215                 220                 


Tyr Phe Tyr Ser Tyr Ile Ile Asp Leu Leu Ser Gly Thr Gly Phe Leu 
225                 230                 235                 240 


Glu Glu Thr Ser Leu Phe Tyr Gly His Tyr Thr Ile Asp Gly Val Lys 
                245                 250                 255     


Phe Gln Asn Phe Thr Tyr Asp Leu Pro Leu Ala Tyr Leu Leu Ser Thr 
            260                 265                 270         


Ile Ala Ser Leu Ala Leu Ser Leu Leu Trp Ile Val Lys Arg Ser Val 
        275                 280                 285             


Glu Gly Phe Lys Ile Asn Leu Ile Arg Ser Glu Glu His Phe Gln Ser 
    290                 295                 300                 


Tyr Cys Asn Lys Ile Phe Ala Gly Trp Asp Phe Cys Ile Thr Asn Arg 
305                 310                 315                 320 


Ser Met Ala Asp Leu Lys His Ser Ser Leu Arg Tyr Glu Leu Arg Ala 
                325                 330                 335     


Asp Leu Glu Glu Glu Arg Met Arg Gln Lys Ile Ala Glu Arg Thr Ser 
            340                 345                 350         


Glu Glu Thr Ile Arg Ile Tyr Ser Leu Arg Leu Phe Leu Asn Cys Ile 
        355                 360                 365             


Val Leu Ala Val Leu Gly Ala Cys Phe Tyr Ala Ile Tyr Val Ala Thr 
    370                 375                 380                 


Val Phe Ser Gln Glu His Met Lys Lys Glu Ile Asp Lys Met Val Phe 
385                 390                 395                 400 


Gly Glu Asn Leu Phe Ile Leu Tyr Leu Pro Ser Ile Val Ile Thr Leu 
                405                 410                 415     


Ala Asn Phe Ile Thr Pro Met Ile Phe Ala Lys Ile Ile Arg Tyr Glu 
            420                 425                 430         


Asp Tyr Ser Pro Gly Phe Glu Ile Arg Leu Thr Ile Leu Arg Cys Val 
        435                 440                 445             


Phe Met Arg Leu Ala Thr Ile Cys Val Leu Val Phe Thr Leu Gly Ser 
    450                 455                 460                 


Lys Ile Thr Ser Cys Asp Asp Asp Thr Cys Asp Leu Cys Gly Tyr Asn 
465                 470                 475                 480 


Gln Lys Leu Tyr Pro Cys Trp Glu Thr Gln Val Gly Gln Glu Met Tyr 
                485                 490                 495     


Lys Leu Met Ile Phe Asp Phe Ile Ile Ile Leu Ala Val Thr Leu Phe 
            500                 505                 510         


Val Asp Phe Pro Arg Lys Leu Leu Val Thr Tyr Cys Ser Ser Cys Lys 
        515                 520                 525             


Leu Ile Gln Cys Trp Gly Gln Gln Glu Phe Ala Ile Pro Asp Asn Val 
    530                 535                 540                 


Leu Gly Ile Val Tyr Gly Gln Thr Ile Cys Trp Ile Gly Ala Phe Phe 
545                 550                 555                 560 


Ser Pro Leu Leu Pro Ala Ile Ala Thr Leu Lys Phe Ile Ile Ile Phe 
                565                 570                 575     


Tyr Val Lys Glu Trp Ser Leu Leu Tyr Thr Cys Arg Pro Ser Pro Arg 
            580                 585                 590         


Pro Phe Arg Ala Ser Asn Ser Asn Phe Phe Phe Leu Leu Val Leu Leu 
        595                 600                 605             


Ile Gly Leu Cys Leu Ala Ile Ile Pro Leu Thr Ile Ser Ile Ser Arg 
    610                 615                 620                 


Ile Pro Ser Ser Lys Ala Cys Gly Pro Phe Thr Asn Phe Asn Thr Thr 
625                 630                 635                 640 


Trp Glu Val Ile Pro Lys Thr Val Ser Thr Phe Pro Ser Ser Leu Gln 
                645                 650                 655     


Ser Phe Ile His Gly Val Thr Ser Glu Ala Phe Ala Val Pro Phe Phe 
            660                 665                 670         


Met Ile Ile Cys Leu Ile Met Phe Tyr Phe Ile Ala Leu Ala Gly Ala 
        675                 680                 685             


His Lys Arg Val Val Ile Gln Leu Arg Glu Gln Leu Ser Leu Val Arg 
    690                 695                 700                 


Lys His Ser Ser Arg Gly Ser Trp Leu Gly Thr Phe Thr Gln Asp Thr 
705                 710                 715                 720 


Ala Arg Lys Val Leu Phe Ser Trp Glu Gly Val Lys Leu Leu Gln Pro 
                725                 730                 735     


Ser Leu Thr Thr Thr Ser Pro Lys Leu Cys Leu Glu Ala Gln Pro Arg 
            740                 745                 750         


Pro Ala Ser Leu Ile His 
        755             

<210>  3207
<211>  2423
<212>  DNA
<213>  Homo sapiens

<400>  3207
actccggctt ctgtgatgtc agcgccggaa cctggaatcc cggctccgcg agggaaggcc     60

ggggaggcgg cggcggcggc ggcggctgga gagggtcctc ggcagcctct gaggagcgcg    120

gggcgcggcc atgagcgagt ccagcggcag tgcgctccag cccggcaggc ccagccggca    180

gccggcggtc catccagaga acctctctct agactccagt tgcttctctt ctccacctgt    240

gaacttcctc caagaattgc caagctaccg gtccattgca cgtaggagaa cgactgtcca    300

ttcccgggac aagcaaagcg gaactttgct aaagccaacc gactcttaca gctcccagct    360

ggaggacaga atcgctgaaa acctcagcag ccattctctt cgaaattatg cactgaacat    420

ctctgagaag cggagactaa gggacattca agagacacaa atgaagtatc tctccgaatg    480

ggaccagtgg aagcggtata gcagcaagtc ttggaagagg ttcctagaga aggctcgaga    540

gatgacgacc cacctggagc tgtggcggga ggacatccgc agcatagaag ggaaatttgg    600

cactgggatt cagtcctatt tctccttctt gagattcctg gtgttgctga atttggtgat    660

atttctgatc atctttatgc tggttttgct cccagtctta ctcacgaaat acaagatcac    720

caacagcagc ttcgtgctca ttcctttcaa agacatggat aaacaatgta cagtctatcc    780

agtaagcagt tctggactca tttactttta cagttatatc atagacttgc tttctggcac    840

tggtttcctg gaggaaacta gcctctttta cggacattac accattgatg gggtgaaatt    900

tcagaacttc acctatgatc tgcccctggc gtatttgtta agcacaatcg cctccctggc    960

cctgagcctt ctttggatag tgaaaaggtc ggtggaagga ttcaaaatca acctgattcg   1020

gagtgaggag cactttcaga gttactgcaa caagatattt gccggctggg acttctgcat   1080

cactaaccgc agcatggcgg atctgaagca cagcagcttg cggtacgagc tccgagcaga   1140

tctggaggaa gaaagaatgc ggcagaaaat agcagaaagg acctcagaag aaacaatacg   1200

catttactct ttgagactgt ttttgaactg tattgttctg gctgttttag gggcatgctt   1260

ttatgcaata tacgtagcaa ctgtcttctc gcaagagcac atgaaaaagg aaatcgacaa   1320

gatggttttt ggagagaacc tcttcatatt gtatctaccg tctattgtga tcacgctggc   1380

caattttatc accccaatga tctttgccaa gatcatccgc tatgaggatt attctccagg   1440

ctttgagatc cgtctgacaa tccttaggtg tgtctttatg cggctggcca ccatatgtgt   1500

cctggtgttc acgctgggct ccaagatcac atcctgtgat gatgacacat gtgacctttg   1560

cggctacaac cagaaactct acccgtgctg ggagacccaa gttgggcagg aaatgtacaa   1620

gctgatgatc ttcgacttca tcatcatctt ggctgtgaca ctcttcgtgg attttcctag   1680

aaagctcctg gtgacctact gttcctcttg caagctgatt cagtgctggg ggcagcagga   1740

gtttgccatt cctgataacg tcctggggat agtttacggg caaaccatct gctggatcgg   1800

agcctttttc tcaccccttc tccctgcaat tgcaaccctg aaattcatta tcatcttcta   1860

tgtgaaagag tggagtctgc tttacacctg cagaccctcc cccaggccgt tcagagcatc   1920

caattctaat ttcttcttcc tgttggtgtt gttgatcggg ctgtgtttgg caataatacc   1980

tctgacaatc agcatatcac gcatcccttc ctcgaaagcc tgtgggccgt tcaccaactt   2040

caacaccacc tgggaggtca tccccaagac ggtgagcacc ttccccagct cgctgcagtc   2100

cttcatccat ggtgtcacat ccgaagcctt tgcagttcct ttcttcatga ttatttgcct   2160

catcatgttt tacttcattg ccttagctgg agcacacaaa cgggtggtca tccagctccg   2220

agagcagcta tccctggaaa gtcgtgacaa gtgctaccta atccagaaac taacagaagc   2280

ccaaagggac atgaggaact aactagactg agcgtgaaga tggtgctgcc tgttgcttct   2340

aagctgacct agtgattctg ctgagcctac agagtctacc tgggttttga gtggacattt   2400

aaaaatatat ttttcttgag ttt                                           2423


<210>  3208
<211>  723
<212>  PRT
<213>  Homo sapiens

<400>  3208


Met Ser Glu Ser Ser Gly Ser Ala Leu Gln Pro Gly Arg Pro Ser Arg 
1               5                   10                  15      


Gln Pro Ala Val His Pro Glu Asn Leu Ser Leu Asp Ser Ser Cys Phe 
            20                  25                  30          


Ser Ser Pro Pro Val Asn Phe Leu Gln Glu Leu Pro Ser Tyr Arg Ser 
        35                  40                  45              


Ile Ala Arg Arg Arg Thr Thr Val His Ser Arg Asp Lys Gln Ser Gly 
    50                  55                  60                  


Thr Leu Leu Lys Pro Thr Asp Ser Tyr Ser Ser Gln Leu Glu Asp Arg 
65                  70                  75                  80  


Ile Ala Glu Asn Leu Ser Ser His Ser Leu Arg Asn Tyr Ala Leu Asn 
                85                  90                  95      


Ile Ser Glu Lys Arg Arg Leu Arg Asp Ile Gln Glu Thr Gln Met Lys 
            100                 105                 110         


Tyr Leu Ser Glu Trp Asp Gln Trp Lys Arg Tyr Ser Ser Lys Ser Trp 
        115                 120                 125             


Lys Arg Phe Leu Glu Lys Ala Arg Glu Met Thr Thr His Leu Glu Leu 
    130                 135                 140                 


Trp Arg Glu Asp Ile Arg Ser Ile Glu Gly Lys Phe Gly Thr Gly Ile 
145                 150                 155                 160 


Gln Ser Tyr Phe Ser Phe Leu Arg Phe Leu Val Leu Leu Asn Leu Val 
                165                 170                 175     


Ile Phe Leu Ile Ile Phe Met Leu Val Leu Leu Pro Val Leu Leu Thr 
            180                 185                 190         


Lys Tyr Lys Ile Thr Asn Ser Ser Phe Val Leu Ile Pro Phe Lys Asp 
        195                 200                 205             


Met Asp Lys Gln Cys Thr Val Tyr Pro Val Ser Ser Ser Gly Leu Ile 
    210                 215                 220                 


Tyr Phe Tyr Ser Tyr Ile Ile Asp Leu Leu Ser Gly Thr Gly Phe Leu 
225                 230                 235                 240 


Glu Glu Thr Ser Leu Phe Tyr Gly His Tyr Thr Ile Asp Gly Val Lys 
                245                 250                 255     


Phe Gln Asn Phe Thr Tyr Asp Leu Pro Leu Ala Tyr Leu Leu Ser Thr 
            260                 265                 270         


Ile Ala Ser Leu Ala Leu Ser Leu Leu Trp Ile Val Lys Arg Ser Val 
        275                 280                 285             


Glu Gly Phe Lys Ile Asn Leu Ile Arg Ser Glu Glu His Phe Gln Ser 
    290                 295                 300                 


Tyr Cys Asn Lys Ile Phe Ala Gly Trp Asp Phe Cys Ile Thr Asn Arg 
305                 310                 315                 320 


Ser Met Ala Asp Leu Lys His Ser Ser Leu Arg Tyr Glu Leu Arg Ala 
                325                 330                 335     


Asp Leu Glu Glu Glu Arg Met Arg Gln Lys Ile Ala Glu Arg Thr Ser 
            340                 345                 350         


Glu Glu Thr Ile Arg Ile Tyr Ser Leu Arg Leu Phe Leu Asn Cys Ile 
        355                 360                 365             


Val Leu Ala Val Leu Gly Ala Cys Phe Tyr Ala Ile Tyr Val Ala Thr 
    370                 375                 380                 


Val Phe Ser Gln Glu His Met Lys Lys Glu Ile Asp Lys Met Val Phe 
385                 390                 395                 400 


Gly Glu Asn Leu Phe Ile Leu Tyr Leu Pro Ser Ile Val Ile Thr Leu 
                405                 410                 415     


Ala Asn Phe Ile Thr Pro Met Ile Phe Ala Lys Ile Ile Arg Tyr Glu 
            420                 425                 430         


Asp Tyr Ser Pro Gly Phe Glu Ile Arg Leu Thr Ile Leu Arg Cys Val 
        435                 440                 445             


Phe Met Arg Leu Ala Thr Ile Cys Val Leu Val Phe Thr Leu Gly Ser 
    450                 455                 460                 


Lys Ile Thr Ser Cys Asp Asp Asp Thr Cys Asp Leu Cys Gly Tyr Asn 
465                 470                 475                 480 


Gln Lys Leu Tyr Pro Cys Trp Glu Thr Gln Val Gly Gln Glu Met Tyr 
                485                 490                 495     


Lys Leu Met Ile Phe Asp Phe Ile Ile Ile Leu Ala Val Thr Leu Phe 
            500                 505                 510         


Val Asp Phe Pro Arg Lys Leu Leu Val Thr Tyr Cys Ser Ser Cys Lys 
        515                 520                 525             


Leu Ile Gln Cys Trp Gly Gln Gln Glu Phe Ala Ile Pro Asp Asn Val 
    530                 535                 540                 


Leu Gly Ile Val Tyr Gly Gln Thr Ile Cys Trp Ile Gly Ala Phe Phe 
545                 550                 555                 560 


Ser Pro Leu Leu Pro Ala Ile Ala Thr Leu Lys Phe Ile Ile Ile Phe 
                565                 570                 575     


Tyr Val Lys Glu Trp Ser Leu Leu Tyr Thr Cys Arg Pro Ser Pro Arg 
            580                 585                 590         


Pro Phe Arg Ala Ser Asn Ser Asn Phe Phe Phe Leu Leu Val Leu Leu 
        595                 600                 605             


Ile Gly Leu Cys Leu Ala Ile Ile Pro Leu Thr Ile Ser Ile Ser Arg 
    610                 615                 620                 


Ile Pro Ser Ser Lys Ala Cys Gly Pro Phe Thr Asn Phe Asn Thr Thr 
625                 630                 635                 640 


Trp Glu Val Ile Pro Lys Thr Val Ser Thr Phe Pro Ser Ser Leu Gln 
                645                 650                 655     


Ser Phe Ile His Gly Val Thr Ser Glu Ala Phe Ala Val Pro Phe Phe 
            660                 665                 670         


Met Ile Ile Cys Leu Ile Met Phe Tyr Phe Ile Ala Leu Ala Gly Ala 
        675                 680                 685             


His Lys Arg Val Val Ile Gln Leu Arg Glu Gln Leu Ser Leu Glu Ser 
    690                 695                 700                 


Arg Asp Lys Cys Tyr Leu Ile Gln Lys Leu Thr Glu Ala Gln Arg Asp 
705                 710                 715                 720 


Met Arg Asn 
            

<210>  3209
<211>  3553
<212>  DNA
<213>  Homo sapiens

<400>  3209
actccggctt ctgtgatgtc agcgccggaa cctggaatcc cggctccgcg agggaaggcc     60

ggggaggcgg cggcggcggc ggcggctgga gagggtcctc ggcagcctct gaggagcgcg    120

gggcgcggcc atgagcgagt ccagcggcag tgcgctccag cccggcaggc ccagccggca    180

gccggcggtc catccagaga acctctctct agactccagt tgcttctctt ctccacctgt    240

gaacttcctc caagaattgc caagctaccg gtccattgca cgtaggagaa cgactgtcca    300

ttcccgggac aagcaaagcg gaactttgct aaagccaacc gactcttaca gctcccagct    360

ggaggacaga atcgctgaaa acctcagcag ccattctctt cgaaattatg cactgaacat    420

ctctgagaag cggagactaa gggacattca agagacacaa atgaagtatc tctccgaatg    480

ggaccagtgg aagcggtata gcagcaagtc ttggaagagg ttcctagaga aggctcgaga    540

gatgacgacc cacctggagc tgtggcggga ggacatccgc agcatagaag ggaaatttgg    600

cactgggatt cagtcctatt tctccttctt gagattcctg gtgttgctga atttggtgat    660

atttctgatc atctttatgc tggttttgct cccagtctta ctcacgaaat acaagatcac    720

caacagcagc ttcgtgctca ttcctttcaa agacatggat aaacaatgta cagtctatcc    780

agtaagcagt tctggactca tttactttta cagttatatc atagacttgc tttctggcac    840

tggtttcctg gaggaaacta gcctctttta cggacattac accattgatg gggtgaaatt    900

tcagaacttc acctatgatc tgcccctggc gtatttgtta agcacaatcg cctccctggc    960

cctgagcctt ctttggatag tgaaaaggtc ggtggaagga ttcaaaatca acctgattcg   1020

gagtgaggag cactttcaga gttactgcaa caagatattt gccggctggg acttctgcat   1080

cactaaccgc agcatggcgg atctgaagca cagcagcttg cggtacgagc tccgagcaga   1140

tctggaggaa gaaagaatgc ggcagaaaat agcagaaagg acctcagaag aaacaatacg   1200

catttactct ttgagactgt ttttgaactg tattgttctg gctgttttag gggcatgctt   1260

ttatgcaata tacgtagcaa ctgtcttctc gcaagagcac atgaaaaagg aaatcgacaa   1320

gatggttttt ggagagaacc tcttcatatt gtatctaccg tctattgtga tcacgctggc   1380

caattttatc accccaatga tctttgccaa gatcatccgc tatgaggatt attctccagg   1440

ctttgagatc cgtctgacaa tccttaggtg tgtctttatg cggctggcca ccatatgtgt   1500

cctggtgttc acgctgggct ccaagatcac atcctgtgat gatgacacat gtgacctttg   1560

cggctacaac cagaaactct acccgtgctg ggagacccaa gttgggcagg aaatgtacaa   1620

gctgatgatc ttcgacttca tcatcatctt ggctgtgaca ctcttcgtgg attttcctag   1680

aaagctcctg gtgacctact gttcctcttg caagctgatt cagtgctggg ggcagcagga   1740

gtttgccatt cctgataacg tcctggggat agtttacggg caaaccatct gctggatcgg   1800

agcctttttc tcaccccttc tccctgcaat tgcaaccctg aaattcatta tcatcttcta   1860

tgtgaaagag tggagtctgc tttacacctg cagaccctcc cccaggccgt tcagagcatc   1920

caattctaat ttcttcttcc tgttggtgtt gttgatcggg ctgtgtttgg caataatacc   1980

tctgacaatc agcatatcac gcatcccttc ctcgaaagcc tgtgggccgt tcaccaactt   2040

caacaccacc tgggaggtca tccccaagac ggtgagcacc ttccccagct cgctgcagtc   2100

cttcatccat ggtgtcacat ccgaagcctt tgcagttcct ttcttcatga ttatttgcct   2160

catcatgttt tacttcattg ccttagctgg agcacacaaa cgggtggtca tccagctccg   2220

agagcagcta tccctggaaa gtcgtgacaa gtgctaccta atccagaaac taacagaagc   2280

ccaaagggac atgaggaact aactagactg agcgtgaaga tggtgctgcc tgttgcttct   2340

aagctgacct agtgattctg ctgagcctac agagtctacc tgggttttga gtggacattt   2400

aaaaatatat ttttcttgag tttaggcttt tccatatgtg cagctgtgtt tacctaaccc   2460

agcccttaat tagggcttca gtgacttaga aaagcagggg aaacccaagg ctttgcctgc   2520

agaccggcca ctctgtgaca actctaccaa aaaccaacaa gccattcaag cttttacaag   2580

aatgaaagag cggagacggt agtttagtat ttgagccacg agtttatgtg cacaagtgtt   2640

ttgggttgtg gactgaagct cagcctgtta atcagaccag cccatgagtg tataacaaac   2700

agaattggag gctggtttct taaacacaca cgtccacatt ttttagggtt gttttcctgt   2760

gcttacaatt tttaatgcat gtgcctttat ttcacaaaac atgtggctgg gcgcagcggc   2820

tcacgcctgt tatcccaaca ctttgggagg ccgaggcagg cggagcacct aagttgggga   2880

gttcaagacc agcctgacca acgtggagaa actccgtctc cactaaaata caaaattagc   2940

tgggtgtggt ggcacatgcc tgtaatatca gctactcagg aggctgaggc aggagaattg   3000

cttgaaccca ggaggtggag tttgcagtga gctgagatca caccattgca ctccagcctg   3060

ggcaaaaaga gcaaaactct ccctaaaaaa aaaatgtaga atatctctta agatttccgt   3120

tatggtaaaa accatatgca ataaatacct cattgtaagc ttacccaaaa ttgatagatg   3180

tcaacctttt aacagaagaa cagaagttta agttattgtt taatgtaatc agttttcatt   3240

ttaatatctt tgaaatcttt ttcaaaggac tgtagttttg taatggactt ttcaagcctt   3300

ccttccattg tttttcttcc gttcactggc tccacacgtt tcctggggag tagcctggaa   3360

tttaaagttg ggtgcaggtt ttagaaagct gttgctgtta acaataattc tcccggccat   3420

ctccactcca ctactcaaaa atgcctgaat ccttgctcag aggagcaaag gtatcttctc   3480

gtccctttct tacagccatt ttcttgcttt tccacaaaga tattatttaa agtggaatat   3540

ttttgtaact ggg                                                      3553


<210>  3210
<211>  723
<212>  PRT
<213>  Homo sapiens

<400>  3210


Met Ser Glu Ser Ser Gly Ser Ala Leu Gln Pro Gly Arg Pro Ser Arg 
1               5                   10                  15      


Gln Pro Ala Val His Pro Glu Asn Leu Ser Leu Asp Ser Ser Cys Phe 
            20                  25                  30          


Ser Ser Pro Pro Val Asn Phe Leu Gln Glu Leu Pro Ser Tyr Arg Ser 
        35                  40                  45              


Ile Ala Arg Arg Arg Thr Thr Val His Ser Arg Asp Lys Gln Ser Gly 
    50                  55                  60                  


Thr Leu Leu Lys Pro Thr Asp Ser Tyr Ser Ser Gln Leu Glu Asp Arg 
65                  70                  75                  80  


Ile Ala Glu Asn Leu Ser Ser His Ser Leu Arg Asn Tyr Ala Leu Asn 
                85                  90                  95      


Ile Ser Glu Lys Arg Arg Leu Arg Asp Ile Gln Glu Thr Gln Met Lys 
            100                 105                 110         


Tyr Leu Ser Glu Trp Asp Gln Trp Lys Arg Tyr Ser Ser Lys Ser Trp 
        115                 120                 125             


Lys Arg Phe Leu Glu Lys Ala Arg Glu Met Thr Thr His Leu Glu Leu 
    130                 135                 140                 


Trp Arg Glu Asp Ile Arg Ser Ile Glu Gly Lys Phe Gly Thr Gly Ile 
145                 150                 155                 160 


Gln Ser Tyr Phe Ser Phe Leu Arg Phe Leu Val Leu Leu Asn Leu Val 
                165                 170                 175     


Ile Phe Leu Ile Ile Phe Met Leu Val Leu Leu Pro Val Leu Leu Thr 
            180                 185                 190         


Lys Tyr Lys Ile Thr Asn Ser Ser Phe Val Leu Ile Pro Phe Lys Asp 
        195                 200                 205             


Met Asp Lys Gln Cys Thr Val Tyr Pro Val Ser Ser Ser Gly Leu Ile 
    210                 215                 220                 


Tyr Phe Tyr Ser Tyr Ile Ile Asp Leu Leu Ser Gly Thr Gly Phe Leu 
225                 230                 235                 240 


Glu Glu Thr Ser Leu Phe Tyr Gly His Tyr Thr Ile Asp Gly Val Lys 
                245                 250                 255     


Phe Gln Asn Phe Thr Tyr Asp Leu Pro Leu Ala Tyr Leu Leu Ser Thr 
            260                 265                 270         


Ile Ala Ser Leu Ala Leu Ser Leu Leu Trp Ile Val Lys Arg Ser Val 
        275                 280                 285             


Glu Gly Phe Lys Ile Asn Leu Ile Arg Ser Glu Glu His Phe Gln Ser 
    290                 295                 300                 


Tyr Cys Asn Lys Ile Phe Ala Gly Trp Asp Phe Cys Ile Thr Asn Arg 
305                 310                 315                 320 


Ser Met Ala Asp Leu Lys His Ser Ser Leu Arg Tyr Glu Leu Arg Ala 
                325                 330                 335     


Asp Leu Glu Glu Glu Arg Met Arg Gln Lys Ile Ala Glu Arg Thr Ser 
            340                 345                 350         


Glu Glu Thr Ile Arg Ile Tyr Ser Leu Arg Leu Phe Leu Asn Cys Ile 
        355                 360                 365             


Val Leu Ala Val Leu Gly Ala Cys Phe Tyr Ala Ile Tyr Val Ala Thr 
    370                 375                 380                 


Val Phe Ser Gln Glu His Met Lys Lys Glu Ile Asp Lys Met Val Phe 
385                 390                 395                 400 


Gly Glu Asn Leu Phe Ile Leu Tyr Leu Pro Ser Ile Val Ile Thr Leu 
                405                 410                 415     


Ala Asn Phe Ile Thr Pro Met Ile Phe Ala Lys Ile Ile Arg Tyr Glu 
            420                 425                 430         


Asp Tyr Ser Pro Gly Phe Glu Ile Arg Leu Thr Ile Leu Arg Cys Val 
        435                 440                 445             


Phe Met Arg Leu Ala Thr Ile Cys Val Leu Val Phe Thr Leu Gly Ser 
    450                 455                 460                 


Lys Ile Thr Ser Cys Asp Asp Asp Thr Cys Asp Leu Cys Gly Tyr Asn 
465                 470                 475                 480 


Gln Lys Leu Tyr Pro Cys Trp Glu Thr Gln Val Gly Gln Glu Met Tyr 
                485                 490                 495     


Lys Leu Met Ile Phe Asp Phe Ile Ile Ile Leu Ala Val Thr Leu Phe 
            500                 505                 510         


Val Asp Phe Pro Arg Lys Leu Leu Val Thr Tyr Cys Ser Ser Cys Lys 
        515                 520                 525             


Leu Ile Gln Cys Trp Gly Gln Gln Glu Phe Ala Ile Pro Asp Asn Val 
    530                 535                 540                 


Leu Gly Ile Val Tyr Gly Gln Thr Ile Cys Trp Ile Gly Ala Phe Phe 
545                 550                 555                 560 


Ser Pro Leu Leu Pro Ala Ile Ala Thr Leu Lys Phe Ile Ile Ile Phe 
                565                 570                 575     


Tyr Val Lys Glu Trp Ser Leu Leu Tyr Thr Cys Arg Pro Ser Pro Arg 
            580                 585                 590         


Pro Phe Arg Ala Ser Asn Ser Asn Phe Phe Phe Leu Leu Val Leu Leu 
        595                 600                 605             


Ile Gly Leu Cys Leu Ala Ile Ile Pro Leu Thr Ile Ser Ile Ser Arg 
    610                 615                 620                 


Ile Pro Ser Ser Lys Ala Cys Gly Pro Phe Thr Asn Phe Asn Thr Thr 
625                 630                 635                 640 


Trp Glu Val Ile Pro Lys Thr Val Ser Thr Phe Pro Ser Ser Leu Gln 
                645                 650                 655     


Ser Phe Ile His Gly Val Thr Ser Glu Ala Phe Ala Val Pro Phe Phe 
            660                 665                 670         


Met Ile Ile Cys Leu Ile Met Phe Tyr Phe Ile Ala Leu Ala Gly Ala 
        675                 680                 685             


His Lys Arg Val Val Ile Gln Leu Arg Glu Gln Leu Ser Leu Glu Ser 
    690                 695                 700                 


Arg Asp Lys Cys Tyr Leu Ile Gln Lys Leu Thr Glu Ala Gln Arg Asp 
705                 710                 715                 720 


Met Arg Asn 
            

<210>  3211
<211>  3637
<212>  DNA
<213>  Homo sapiens

<400>  3211
actccggctt ctgtgatgtc agcgccggaa cctggaatcc cggctccgcg agggaaggcc     60

ggggaggcgg cggcggcggc ggcggctgga gagggtcctc ggcagcctct gaggagcgcg    120

gggcgcggcc atgagcgagt ccagcggcag tgcgctccag cccggcaggc ccagccggca    180

gccggcggtc catccagaga acctctctct agactccagt tgcttctctt ctccacctgt    240

gaacttcctc caagaattgc caagctaccg gtccattgca cgtaggagaa cgactgtcca    300

ttcccgggac aagcaaagcg gaactttgct aaagccaacc gactcttaca gctcccagct    360

ggaggacaga atcgctgaaa acctcagcag ccattctctt cgaaattatg cactgaacat    420

ctctgagaag cggagactaa gggacattca agagacacaa atgaagtatc tctccgaatg    480

ggaccagtgg aagcggtata gcagcaagtc ttggaagagg ttcctagaga aggctcgaga    540

gatgacgacc cacctggagc tgtggcggga ggacatccgc agcatagaag ggaaatttgg    600

cactgggatt cagtcctatt tctccttctt gagattcctg gtgttgctga atttggtgat    660

atttctgatc atctttatgc tggttttgct cccagtctta ctcacgaaat acaagatcac    720

caacagcagc ttcgtgctca ttcctttcaa agacatggat aaacaatgta cagtctatcc    780

agtaagcagt tctggactca tttactttta cagttatatc atagacttgc tttctggcac    840

tggtttcctg gaggaaacta gcctctttta cggacattac accattgatg gggtgaaatt    900

tcagaacttc acctatgatc tgcccctggc gtatttgtta agcacaatcg cctccctggc    960

cctgagcctt ctttggatag tgaaaaggtc ggtggaagga ttcaaaatca acctgattcg   1020

gagtgaggag cactttcaga gttactgcaa caagatattt gccggctggg acttctgcat   1080

cactaaccgc agcatggcgg atctgaagca cagcagcttg cggtacgagc tccgagcaga   1140

tctggaggaa gaaagaatgc ggcagaaaat agcagaaagg acctcagaag aaacaatacg   1200

catttactct ttgagactgt ttttgaactg tattgttctg gctgttttag gggcatgctt   1260

ttatgcaata tacgtagcaa ctgtcttctc gcaagagcac atgaaaaagg aaatcgacaa   1320

gatggttttt ggagagaacc tcttcatatt gtatctaccg tctattgtga tcacgctggc   1380

caattttatc accccaatga tctttgccaa gatcatccgc tatgaggatt attctccagg   1440

ctttgagatc cgtctgacaa tccttaggtg tgtctttatg cggctggcca ccatatgtgt   1500

cctggtgttc acgctgggct ccaagatcac atcctgtgat gatgacacat gtgacctttg   1560

cggctacaac cagaaactct acccgtgctg ggagacccaa gttgggcagg aaatgtacaa   1620

gctgatgatc ttcgacttca tcatcatctt ggctgtgaca ctcttcgtgg attttcctag   1680

aaagctcctg gtgacctact gttcctcttg caagctgatt cagtgctggg ggcagcagga   1740

gtttgccatt cctgataacg tcctggggat agtttacggg caaaccatct gctggatcgg   1800

agcctttttc tcaccccttc tccctgcaat tgcaaccctg aaattcatta tcatcttcta   1860

tgtgaaagag tggagtctgc tttacacctg cagaccctcc cccaggccgt tcagagcatc   1920

caattctaat ttcttcttcc tgttggtgtt gttgatcggg ctgtgtttgg caataatacc   1980

tctgacaatc agcatatcac gcatcccttc ctcgaaagcc tgtgggccgt tcaccaactt   2040

caacaccacc tgggaggtca tccccaagac ggtgagcacc ttccccagct cgctgcagtc   2100

cttcatccat ggtgtcacat ccgaagcctt tgcagttcct ttcttcatga ttatttgcct   2160

catcatgttt tacttcattg ccttagctgg agcacacaaa cgggtggtca tccagctccg   2220

agagcagcta tccctggaaa gtcgtgacaa gtgctaccta atccagaaac taacagaagc   2280

ccaaagggac atgaggaact aactagactg agcgtgaaga tggtgctgcc tgttgcttct   2340

aagctgacct agtgattctg ctgagcctac agagtctacc tgggttttga gtggacattt   2400

aaaaatatat ttttcttgag tttaggcttt tccatatgtg cagctgtgtt tacctaaccc   2460

agcccttaat tagggcttca gtgacttaga aaagcagggg aaacccaagg ctttgcctgc   2520

agaccggcca ctctgtgaca actctaccaa aaaccaacaa gccattcaag cttttacaag   2580

aatgaaagag cggagacggt agtttagtat ttgagccacg agtttatgtg cacaagtgtt   2640

ttgggttgtg gactgaagct cagcctgtta atcagaccag cccatgagtg tataacaaac   2700

agaattggag gctggtttct taaacacaca cgtccacatt ttttagggtt gttttcctgt   2760

gcttacaatt tttaatgcat gtgcctttat ttcacaaaac atgtggctgg gcgcagcggc   2820

tcacgcctgt tatcccaaca ctttgggagg ccgaggcagg cggagcacct aagttgggga   2880

gttcaagacc agcctgacca acgtggagaa actccgtctc cactaaaata caaaattagc   2940

tgggtgtggt ggcacatgcc tgtaatatca gctactcagg aggctgaggc aggagaattg   3000

cttgaaccca ggaggtggag tttgcagtga gctgagatca caccattgca ctccagcctg   3060

ggcaaaaaga gcaaaactct ccctaaaaaa aaaatgtaga atatctctta agatttccgt   3120

tatggtaaaa accatatgca ataaatacct cattgtaagc ttacccaaaa ttgatagatg   3180

tcaacctttt aacagaagaa cagaagttta agttattgtt taatgtaatc agttttcatt   3240

ttaatatctt tgaaatcttt ttcaaaggac tgtagttttg taatggactt ttcaagcctt   3300

ccttccattg tttttcttcc gttcactggc tccacacgtt tcctggggag tagcctggaa   3360

tttaaagttg ggtgcaggtt ttagaaagct gttgctgtta acaataattc tcccggccat   3420

ctccactcca ctactcaaaa atgcctgaat ccttgctcag aggagcaaag gtatcttctc   3480

gtccctttct tacagccatt ttcttgcttt tccacaaaga tattatttaa agtggaatat   3540

ttttgtaact gggataccaa tgagcttttc ggtcttttcc tgacttggta aggtttatgg   3600

gtttctaaat ctaataacta cagtcatacc accctga                            3637


<210>  3212
<211>  723
<212>  PRT
<213>  Homo sapiens

<400>  3212


Met Ser Glu Ser Ser Gly Ser Ala Leu Gln Pro Gly Arg Pro Ser Arg 
1               5                   10                  15      


Gln Pro Ala Val His Pro Glu Asn Leu Ser Leu Asp Ser Ser Cys Phe 
            20                  25                  30          


Ser Ser Pro Pro Val Asn Phe Leu Gln Glu Leu Pro Ser Tyr Arg Ser 
        35                  40                  45              


Ile Ala Arg Arg Arg Thr Thr Val His Ser Arg Asp Lys Gln Ser Gly 
    50                  55                  60                  


Thr Leu Leu Lys Pro Thr Asp Ser Tyr Ser Ser Gln Leu Glu Asp Arg 
65                  70                  75                  80  


Ile Ala Glu Asn Leu Ser Ser His Ser Leu Arg Asn Tyr Ala Leu Asn 
                85                  90                  95      


Ile Ser Glu Lys Arg Arg Leu Arg Asp Ile Gln Glu Thr Gln Met Lys 
            100                 105                 110         


Tyr Leu Ser Glu Trp Asp Gln Trp Lys Arg Tyr Ser Ser Lys Ser Trp 
        115                 120                 125             


Lys Arg Phe Leu Glu Lys Ala Arg Glu Met Thr Thr His Leu Glu Leu 
    130                 135                 140                 


Trp Arg Glu Asp Ile Arg Ser Ile Glu Gly Lys Phe Gly Thr Gly Ile 
145                 150                 155                 160 


Gln Ser Tyr Phe Ser Phe Leu Arg Phe Leu Val Leu Leu Asn Leu Val 
                165                 170                 175     


Ile Phe Leu Ile Ile Phe Met Leu Val Leu Leu Pro Val Leu Leu Thr 
            180                 185                 190         


Lys Tyr Lys Ile Thr Asn Ser Ser Phe Val Leu Ile Pro Phe Lys Asp 
        195                 200                 205             


Met Asp Lys Gln Cys Thr Val Tyr Pro Val Ser Ser Ser Gly Leu Ile 
    210                 215                 220                 


Tyr Phe Tyr Ser Tyr Ile Ile Asp Leu Leu Ser Gly Thr Gly Phe Leu 
225                 230                 235                 240 


Glu Glu Thr Ser Leu Phe Tyr Gly His Tyr Thr Ile Asp Gly Val Lys 
                245                 250                 255     


Phe Gln Asn Phe Thr Tyr Asp Leu Pro Leu Ala Tyr Leu Leu Ser Thr 
            260                 265                 270         


Ile Ala Ser Leu Ala Leu Ser Leu Leu Trp Ile Val Lys Arg Ser Val 
        275                 280                 285             


Glu Gly Phe Lys Ile Asn Leu Ile Arg Ser Glu Glu His Phe Gln Ser 
    290                 295                 300                 


Tyr Cys Asn Lys Ile Phe Ala Gly Trp Asp Phe Cys Ile Thr Asn Arg 
305                 310                 315                 320 


Ser Met Ala Asp Leu Lys His Ser Ser Leu Arg Tyr Glu Leu Arg Ala 
                325                 330                 335     


Asp Leu Glu Glu Glu Arg Met Arg Gln Lys Ile Ala Glu Arg Thr Ser 
            340                 345                 350         


Glu Glu Thr Ile Arg Ile Tyr Ser Leu Arg Leu Phe Leu Asn Cys Ile 
        355                 360                 365             


Val Leu Ala Val Leu Gly Ala Cys Phe Tyr Ala Ile Tyr Val Ala Thr 
    370                 375                 380                 


Val Phe Ser Gln Glu His Met Lys Lys Glu Ile Asp Lys Met Val Phe 
385                 390                 395                 400 


Gly Glu Asn Leu Phe Ile Leu Tyr Leu Pro Ser Ile Val Ile Thr Leu 
                405                 410                 415     


Ala Asn Phe Ile Thr Pro Met Ile Phe Ala Lys Ile Ile Arg Tyr Glu 
            420                 425                 430         


Asp Tyr Ser Pro Gly Phe Glu Ile Arg Leu Thr Ile Leu Arg Cys Val 
        435                 440                 445             


Phe Met Arg Leu Ala Thr Ile Cys Val Leu Val Phe Thr Leu Gly Ser 
    450                 455                 460                 


Lys Ile Thr Ser Cys Asp Asp Asp Thr Cys Asp Leu Cys Gly Tyr Asn 
465                 470                 475                 480 


Gln Lys Leu Tyr Pro Cys Trp Glu Thr Gln Val Gly Gln Glu Met Tyr 
                485                 490                 495     


Lys Leu Met Ile Phe Asp Phe Ile Ile Ile Leu Ala Val Thr Leu Phe 
            500                 505                 510         


Val Asp Phe Pro Arg Lys Leu Leu Val Thr Tyr Cys Ser Ser Cys Lys 
        515                 520                 525             


Leu Ile Gln Cys Trp Gly Gln Gln Glu Phe Ala Ile Pro Asp Asn Val 
    530                 535                 540                 


Leu Gly Ile Val Tyr Gly Gln Thr Ile Cys Trp Ile Gly Ala Phe Phe 
545                 550                 555                 560 


Ser Pro Leu Leu Pro Ala Ile Ala Thr Leu Lys Phe Ile Ile Ile Phe 
                565                 570                 575     


Tyr Val Lys Glu Trp Ser Leu Leu Tyr Thr Cys Arg Pro Ser Pro Arg 
            580                 585                 590         


Pro Phe Arg Ala Ser Asn Ser Asn Phe Phe Phe Leu Leu Val Leu Leu 
        595                 600                 605             


Ile Gly Leu Cys Leu Ala Ile Ile Pro Leu Thr Ile Ser Ile Ser Arg 
    610                 615                 620                 


Ile Pro Ser Ser Lys Ala Cys Gly Pro Phe Thr Asn Phe Asn Thr Thr 
625                 630                 635                 640 


Trp Glu Val Ile Pro Lys Thr Val Ser Thr Phe Pro Ser Ser Leu Gln 
                645                 650                 655     


Ser Phe Ile His Gly Val Thr Ser Glu Ala Phe Ala Val Pro Phe Phe 
            660                 665                 670         


Met Ile Ile Cys Leu Ile Met Phe Tyr Phe Ile Ala Leu Ala Gly Ala 
        675                 680                 685             


His Lys Arg Val Val Ile Gln Leu Arg Glu Gln Leu Ser Leu Glu Ser 
    690                 695                 700                 


Arg Asp Lys Cys Tyr Leu Ile Gln Lys Leu Thr Glu Ala Gln Arg Asp 
705                 710                 715                 720 


Met Arg Asn 
            

<210>  3213
<211>  4495
<212>  DNA
<213>  Homo sapiens

<400>  3213
ttccttattc ctgctccctc cacaaacgcg tcctcatcca atccagtgga acccagccgg     60

gccaaaagga cacgagaact gcagtctgga ccgtggtggg tttgtcttcc agctgttgac    120

cgagacagtc tttcaatagc ctcatctgct gttaaatgaa aggatttgag caccccctcc    180

acgcctaaca ttctggtatg aggtgcctgc ctcccggaca tttcagcctt cacatacagt    240

tagaccaact tgaaaccgaa ttctgccttg tctgtttatt gctgtgggac ctttgagaac    300

ctctctctag actccagttg cttctcttct ccacctgtga acttcctcca agaattgcca    360

agctaccggt ccattgcacg taggagaacg actgtccatt cccgggacaa gcaaagcgga    420

actttgctaa agccaaccga ctcttacagc tcccagctgg aggacagaat cgctgaaaac    480

ctcagcagcc attctcttcg aaattatgca ctgaacatct ctgagaagcg gagactaagg    540

gacattcaag agacacaaat gaagtatctc tccgaatggg accagtggaa gcggtatagc    600

agcaagtctt ggaagaggtt cctagagaag gctcgagaga tgacgaccca cctggagctg    660

tggcgggagg acatccgcag catagaaggg aaatttggca ctgggattca gtcctatttc    720

tccttcttga gattcctggt gttgctgaat ttggtgatat ttctgatcat ctttatgctg    780

gttttgctcc cagtcttact cacgaaatac aagatcacca acagcagctt cgtgctcatt    840

cctttcaaag acatggataa acaatgtaca gtctatccag taagcagttc tggactcatt    900

tacttttaca gttatatcat agacttgctt tctggcactg gtttcctgga ggaaactagc    960

ctcttttacg gacattacac cattgatggg gtgaaatttc agaacttcac ctatgatctg   1020

cccctggcgt atttgttaag cacaatcgcc tccctggccc tgagccttct ttggatagtg   1080

aaaaggtcgg tggaaggatt caaaatcaac ctgattcgga gtgaggagca ctttcagagt   1140

tactgcaaca agatatttgc cggctgggac ttctgcatca ctaaccgcag catggcggat   1200

ctgaagcaca gcagcttgcg gtacgagctc cgagcagatc tggaggaaga aagaatgcgg   1260

cagaaaatag cagaaaggac ctcagaagaa acaatacgca tttactcttt gagactgttt   1320

ttgaactgta ttgttctggc tgttttaggg gcatgctttt atgcaatata cgtagcaact   1380

gtcttctcgc aagagcacat gaaaaaggaa atcgacaaga tggtttttgg agagaacctc   1440

ttcatattgt atctaccgtc tattgtgatc acgctggcca attttatcac cccaatgatc   1500

tttgccaaga tcatccgcta tgaggattat tctccaggct ttgagatccg tctgacaatc   1560

cttaggtgtg tctttatgcg gctggccacc atatgtgtcc tggtgttcac gctgggctcc   1620

aagatcacat cctgtgatga tgacacatgt gacctttgcg gctacaacca gaaactctac   1680

ccgtgctggg agacccaagt tgggcaggaa atgtacaagc tgatgatctt cgacttcatc   1740

atcatcttgg ctgtgacact cttcgtggat tttcctagaa agctcctggt gacctactgt   1800

tcctcttgca agctgattca gtgctggggg cagcaggagt ttgccattcc tgataacgtc   1860

ctggggatag tttacgggca aaccatctgc tggatcggag cctttttctc accccttctc   1920

cctgcaattg caaccctgaa attcattatc atcttctatg tgaaagagtg gagtctgctt   1980

tacacctgca gaccctcccc caggccgttc agagcatcca attctaattt cttcttcctg   2040

ttggtgttgt tgatcgggct gtgtttggca ataatacctc tgacaatcag catatcacgc   2100

atcccttcct cgaaagcctg tgggccgttc accaacttca acaccacctg ggaggtcatc   2160

cccaagacgg tgagcacctt ccccagctcg ctgcagtcct tcatccatgg tgtcacatcc   2220

gaagcctttg cagttccttt cttcatgatt atttgcctca tcatgtttta cttcattgcc   2280

ttagctggag cacacaaacg ggtggtcatc cagctccgag agcagctatc cctggaaagt   2340

cgtgacaagt gctacctaat ccagaaacta acagaagccc aaagggacat gaggaactaa   2400

ctagactgag cgtgaagatg gtgctgcctg ttgcttctaa gctgacctag tgattctgct   2460

gagcctacag agtctacctg ggttttgagt ggacatttaa aaatatattt ttcttgagtt   2520

taggcttttc catatgtgca gctgtgttta cctaacccag cccttaatta gggcttcagt   2580

gacttagaaa agcaggggaa acccaaggct ttgcctgcag accggccact ctgtgacaac   2640

tctaccaaaa accaacaagc cattcaagct tttacaagaa tgaaagagcg gagacggtag   2700

tttagtattt gagccacgag tttatgtgca caagtgtttt gggttgtgga ctgaagctca   2760

gcctgttaat cagaccagcc catgagtgta taacaaacag aattggaggc tggtttctta   2820

aacacacacg tccacatttt ttagggttgt tttcctgtgc ttacaatttt taatgcatgt   2880

gcctttattt cacaaaacat gtggctgggc gcagcggctc acgcctgtta tcccaacact   2940

ttgggaggcc gaggcaggcg gagcacctaa gttggggagt tcaagaccag cctgaccaac   3000

gtggagaaac tccgtctcca ctaaaataca aaattagctg ggtgtggtgg cacatgcctg   3060

taatatcagc tactcaggag gctgaggcag gagaattgct tgaacccagg aggtggagtt   3120

tgcagtgagc tgagatcaca ccattgcact ccagcctggg caaaaagagc aaaactctcc   3180

ctaaaaaaaa aatgtagaat atctcttaag atttccgtta tggtaaaaac catatgcaat   3240

aaatacctca ttgtaagctt acccaaaatt gatagatgtc aaccttttaa cagaagaaca   3300

gaagtttaag ttattgttta atgtaatcag ttttcatttt aatatctttg aaatcttttt   3360

caaaggactg tagttttgta atggactttt caagccttcc ttccattgtt tttcttccgt   3420

tcactggctc cacacgtttc ctggggagta gcctggaatt taaagttggg tgcaggtttt   3480

agaaagctgt tgctgttaac aataattctc ccggccatct ccactccact actcaaaaat   3540

gcctgaatcc ttgctcagag gagcaaaggt atcttctcgt ccctttctta cagccatttt   3600

cttgcttttc cacaaagata ttatttaaag tggaatattt ttgtaactgg gataccaatg   3660

agcttttcgg tcttttcctg acttggtaag gtttatgggt ttctaaatct aataactaca   3720

gtcataccac cctgaaaatg cctgatctcg tctaaatcta ataactggtg tcatggaatt   3780

ttgagtaacc aaagattcat tccagtctca cttaaaaaaa taaattctgc tgggcacagt   3840

ggctcatgcc tgcaatccca gaactttggg agtccaagga gggcagatca cctgaagtca   3900

gaagtttgag accagcctgg tcaatgtggc aagaccccgt ctctactaaa agtacaaaaa   3960

ttagccaggc atggtggcgt gtgcctgtaa tcccagctac ttgggaggct gaggcatgag   4020

aatcacttga acctgggagg tgaaggctgc agtgtgcgag accgtgccac tgtactccag   4080

cctaggtgac agagggagac cctatctcaa aaaaaaagat aggtgaaaag aaaaaaaaag   4140

ttgtaattgt aaacatttct gcccagtgcc tttatattta tataacattt tcactgtgac   4200

cagacttgat gatattcaag ttttctattt gtgtgtgtgt gtgtgtgtgt gtgtgatgaa   4260

cacaacgaaa acgtactgcg ttttttttcc tattataaaa gtgatactga aatatgctaa   4320

ttaatatatt aattttagtt aaatgctgct aatatgcata cctcttactt gaaggttttt   4380

aatatgtttt gataacttta ataacttcag gtgatgtctg tataactttt aaagtgcagc   4440

tctctctaac aaatgtgcct tacaactcct gattaaacgg cgtcttgaag gtttt        4495


<210>  3214
<211>  613
<212>  PRT
<213>  Homo sapiens

<400>  3214


Met Lys Tyr Leu Ser Glu Trp Asp Gln Trp Lys Arg Tyr Ser Ser Lys 
1               5                   10                  15      


Ser Trp Lys Arg Phe Leu Glu Lys Ala Arg Glu Met Thr Thr His Leu 
            20                  25                  30          


Glu Leu Trp Arg Glu Asp Ile Arg Ser Ile Glu Gly Lys Phe Gly Thr 
        35                  40                  45              


Gly Ile Gln Ser Tyr Phe Ser Phe Leu Arg Phe Leu Val Leu Leu Asn 
    50                  55                  60                  


Leu Val Ile Phe Leu Ile Ile Phe Met Leu Val Leu Leu Pro Val Leu 
65                  70                  75                  80  


Leu Thr Lys Tyr Lys Ile Thr Asn Ser Ser Phe Val Leu Ile Pro Phe 
                85                  90                  95      


Lys Asp Met Asp Lys Gln Cys Thr Val Tyr Pro Val Ser Ser Ser Gly 
            100                 105                 110         


Leu Ile Tyr Phe Tyr Ser Tyr Ile Ile Asp Leu Leu Ser Gly Thr Gly 
        115                 120                 125             


Phe Leu Glu Glu Thr Ser Leu Phe Tyr Gly His Tyr Thr Ile Asp Gly 
    130                 135                 140                 


Val Lys Phe Gln Asn Phe Thr Tyr Asp Leu Pro Leu Ala Tyr Leu Leu 
145                 150                 155                 160 


Ser Thr Ile Ala Ser Leu Ala Leu Ser Leu Leu Trp Ile Val Lys Arg 
                165                 170                 175     


Ser Val Glu Gly Phe Lys Ile Asn Leu Ile Arg Ser Glu Glu His Phe 
            180                 185                 190         


Gln Ser Tyr Cys Asn Lys Ile Phe Ala Gly Trp Asp Phe Cys Ile Thr 
        195                 200                 205             


Asn Arg Ser Met Ala Asp Leu Lys His Ser Ser Leu Arg Tyr Glu Leu 
    210                 215                 220                 


Arg Ala Asp Leu Glu Glu Glu Arg Met Arg Gln Lys Ile Ala Glu Arg 
225                 230                 235                 240 


Thr Ser Glu Glu Thr Ile Arg Ile Tyr Ser Leu Arg Leu Phe Leu Asn 
                245                 250                 255     


Cys Ile Val Leu Ala Val Leu Gly Ala Cys Phe Tyr Ala Ile Tyr Val 
            260                 265                 270         


Ala Thr Val Phe Ser Gln Glu His Met Lys Lys Glu Ile Asp Lys Met 
        275                 280                 285             


Val Phe Gly Glu Asn Leu Phe Ile Leu Tyr Leu Pro Ser Ile Val Ile 
    290                 295                 300                 


Thr Leu Ala Asn Phe Ile Thr Pro Met Ile Phe Ala Lys Ile Ile Arg 
305                 310                 315                 320 


Tyr Glu Asp Tyr Ser Pro Gly Phe Glu Ile Arg Leu Thr Ile Leu Arg 
                325                 330                 335     


Cys Val Phe Met Arg Leu Ala Thr Ile Cys Val Leu Val Phe Thr Leu 
            340                 345                 350         


Gly Ser Lys Ile Thr Ser Cys Asp Asp Asp Thr Cys Asp Leu Cys Gly 
        355                 360                 365             


Tyr Asn Gln Lys Leu Tyr Pro Cys Trp Glu Thr Gln Val Gly Gln Glu 
    370                 375                 380                 


Met Tyr Lys Leu Met Ile Phe Asp Phe Ile Ile Ile Leu Ala Val Thr 
385                 390                 395                 400 


Leu Phe Val Asp Phe Pro Arg Lys Leu Leu Val Thr Tyr Cys Ser Ser 
                405                 410                 415     


Cys Lys Leu Ile Gln Cys Trp Gly Gln Gln Glu Phe Ala Ile Pro Asp 
            420                 425                 430         


Asn Val Leu Gly Ile Val Tyr Gly Gln Thr Ile Cys Trp Ile Gly Ala 
        435                 440                 445             


Phe Phe Ser Pro Leu Leu Pro Ala Ile Ala Thr Leu Lys Phe Ile Ile 
    450                 455                 460                 


Ile Phe Tyr Val Lys Glu Trp Ser Leu Leu Tyr Thr Cys Arg Pro Ser 
465                 470                 475                 480 


Pro Arg Pro Phe Arg Ala Ser Asn Ser Asn Phe Phe Phe Leu Leu Val 
                485                 490                 495     


Leu Leu Ile Gly Leu Cys Leu Ala Ile Ile Pro Leu Thr Ile Ser Ile 
            500                 505                 510         


Ser Arg Ile Pro Ser Ser Lys Ala Cys Gly Pro Phe Thr Asn Phe Asn 
        515                 520                 525             


Thr Thr Trp Glu Val Ile Pro Lys Thr Val Ser Thr Phe Pro Ser Ser 
    530                 535                 540                 


Leu Gln Ser Phe Ile His Gly Val Thr Ser Glu Ala Phe Ala Val Pro 
545                 550                 555                 560 


Phe Phe Met Ile Ile Cys Leu Ile Met Phe Tyr Phe Ile Ala Leu Ala 
                565                 570                 575     


Gly Ala His Lys Arg Val Val Ile Gln Leu Arg Glu Gln Leu Ser Leu 
            580                 585                 590         


Glu Ser Arg Asp Lys Cys Tyr Leu Ile Gln Lys Leu Thr Glu Ala Gln 
        595                 600                 605             


Arg Asp Met Arg Asn 
    610             

<210>  3215
<211>  2586
<212>  DNA
<213>  Homo sapiens

<400>  3215
gccaatgggc gcgcggggag gcgcgggccg cggcggcggg ctgggggctc ggcgctcccg     60

ggcgtcagtc gggccgcggc gacggcggca ggagcgcgtc ccggcgccgc ctcgggctcc    120

gctcggctcg ggggctgctt cgggaggagg agagccaagg gaggcgccag gcccgcgggc    180

cgggcgcatg gcttagggac gctcccggcc gccgcagccc cagcatgggg aaacttcact    240

ccaagccggc cgccgtgtgc aagcgcaggg agagcccgga aggtgacagc ttcgccgtga    300

gcgctgcctg ggctcggaag ggcatcgagg agtggatcgg gagacagcgc tgcccgggcg    360

gtgtctcggg accccgacag ctgcggttgg cgggcaccat aggccgaagc acccgggagc    420

tcgtgggcga cgtgttgaga gacacgctca gcgaggaaga ggaggacgac tttcggctgg    480

aagtggccct gcctcctgag aagactgacg ggctgggcag cggagatgag aagaagatgg    540

agagagtgag cgaaccctgc ccaggctcca agaagcagct gaagtttgaa gagctccagt    600

gcgacgtgtc catggaggag gacagccggc aggagtggac cttcaccctg tatgactttg    660

acaacaacgg caaggtcacc cgagaggaca tcaccagctt gctgcacacc atctatgagg    720

tggtggactc ctctgtcaac cactccccaa catccagcaa gatgctgcgg gtaaagctca    780

ccgtggcccc cgatggcagc cagagcaaga ggagcgtcct tgtcaatcag gctgacctgc    840

agagcgcaag gccccgagca gagaccaagc ccactgagga cctgcggagc tgggagaaga    900

agcagcgagc cccgctcagg ttccagggtg acagccgcct ggagcagtct ggctgctacc    960

accattgcgt agatgagaac atcgagagga gaaaccacta cttagatctc gccgggatag   1020

aaaactacac gtcccaattt gggcctggct ccccttccgt ggcccagaag tcagaactgc   1080

ccccccgcac ctccaatccc actcgatctc gctcccatga gccggaagcc atccacatcc   1140

cacaccgaaa gccccaaggc gtggacccgg cctccttcca cttccttgac accccaatcg   1200

ccaaggtctc agagctccag caacggctcc ggggcaccca ggacgggagc aagcactttg   1260

tgaggtcccc caaggcccag ggcaagagtg tgggtgtggg ccacgtggcc agaggggcaa   1320

gaaacaagcc ccctctggga cccgccatcc ctgcggtgtc cccctccgcc cacctggctg   1380

ccagcccggc cctcctcccc tccctagccc ccctcgggca caagaagcac aagcaccgag   1440

ccaaggagag ccagcagggc tgccggggcc tgcaggcacc actggcctca ggtggccctg   1500

tcctggggcg ggagcacctg cgggagctgc ccgccttggt ggtgtatgag agccaggccg   1560

ggcagccggt ccagagacat gagcaccacc accaccatga acatcaccac cattaccacc   1620

acttctacca gacatagagc ccctccccag ggccccaccc tgccatatga aggaccccac   1680

ccccgacacc acaaggcatt attattctat taattattgt tattatgatg attattgtta   1740

ttaataatta ttgttactcc actaatattt agctagccta catgtagaag atctatggaa   1800

acacagaact aaacttttat ttatatgttg tggggactgc ataactagcc caggaaatga   1860

ctctggtttt gagtggcctg taatgggcag aggctccctc ggggctcggg atctgcagca   1920

tctatgtgga tcagcccaca cccttcccag agccagggag cccttagcct caactctgcc   1980

ccaccccagc ctcttccagg agagcaccct tacttggccc ggcttccaga gaccctcgaa   2040

atctccgaga agataaacag ctgctacctc ttagtattat tctgatttta ttttgccctt   2100

aactgattgt tatatgctac aagggatttc agtggactgc agagtgcgaa cgtcttgctg   2160

ttgtgttttt atgtcccaac ctagaaacct tagctgtctt ttctggagtt gtctttcatg   2220

cttttccagt gggatcaagc ccttttcccc aagagtccca tctcttctgc catgcacgac   2280

atgaaaatcc acttctcttc cttctccttc ttctctctct actttacagt gatacacaca   2340

cgtatttaag gactatccct gagaccatcc ttctcatttt ggaaactgct agggagggaa   2400

ccaaccactt aaacaagcgt ggttttccaa gatccaggca attgtgtgct gttggttgtg   2460

gtggaggatg tggcacatat atacgtacct acacggttct ctaacagagc tttctgtatc   2520

tatagataga tgccatctgt ccatttctat gtatctttct ataaatatac actctcaggt   2580

atcttt                                                              2586


<210>  3216
<211>  470
<212>  PRT
<213>  Homo sapiens

<400>  3216


Met Gly Lys Leu His Ser Lys Pro Ala Ala Val Cys Lys Arg Arg Glu 
1               5                   10                  15      


Ser Pro Glu Gly Asp Ser Phe Ala Val Ser Ala Ala Trp Ala Arg Lys 
            20                  25                  30          


Gly Ile Glu Glu Trp Ile Gly Arg Gln Arg Cys Pro Gly Gly Val Ser 
        35                  40                  45              


Gly Pro Arg Gln Leu Arg Leu Ala Gly Thr Ile Gly Arg Ser Thr Arg 
    50                  55                  60                  


Glu Leu Val Gly Asp Val Leu Arg Asp Thr Leu Ser Glu Glu Glu Glu 
65                  70                  75                  80  


Asp Asp Phe Arg Leu Glu Val Ala Leu Pro Pro Glu Lys Thr Asp Gly 
                85                  90                  95      


Leu Gly Ser Gly Asp Glu Lys Lys Met Glu Arg Val Ser Glu Pro Cys 
            100                 105                 110         


Pro Gly Ser Lys Lys Gln Leu Lys Phe Glu Glu Leu Gln Cys Asp Val 
        115                 120                 125             


Ser Met Glu Glu Asp Ser Arg Gln Glu Trp Thr Phe Thr Leu Tyr Asp 
    130                 135                 140                 


Phe Asp Asn Asn Gly Lys Val Thr Arg Glu Asp Ile Thr Ser Leu Leu 
145                 150                 155                 160 


His Thr Ile Tyr Glu Val Val Asp Ser Ser Val Asn His Ser Pro Thr 
                165                 170                 175     


Ser Ser Lys Met Leu Arg Val Lys Leu Thr Val Ala Pro Asp Gly Ser 
            180                 185                 190         


Gln Ser Lys Arg Ser Val Leu Val Asn Gln Ala Asp Leu Gln Ser Ala 
        195                 200                 205             


Arg Pro Arg Ala Glu Thr Lys Pro Thr Glu Asp Leu Arg Ser Trp Glu 
    210                 215                 220                 


Lys Lys Gln Arg Ala Pro Leu Arg Phe Gln Gly Asp Ser Arg Leu Glu 
225                 230                 235                 240 


Gln Ser Gly Cys Tyr His His Cys Val Asp Glu Asn Ile Glu Arg Arg 
                245                 250                 255     


Asn His Tyr Leu Asp Leu Ala Gly Ile Glu Asn Tyr Thr Ser Gln Phe 
            260                 265                 270         


Gly Pro Gly Ser Pro Ser Val Ala Gln Lys Ser Glu Leu Pro Pro Arg 
        275                 280                 285             


Thr Ser Asn Pro Thr Arg Ser Arg Ser His Glu Pro Glu Ala Ile His 
    290                 295                 300                 


Ile Pro His Arg Lys Pro Gln Gly Val Asp Pro Ala Ser Phe His Phe 
305                 310                 315                 320 


Leu Asp Thr Pro Ile Ala Lys Val Ser Glu Leu Gln Gln Arg Leu Arg 
                325                 330                 335     


Gly Thr Gln Asp Gly Ser Lys His Phe Val Arg Ser Pro Lys Ala Gln 
            340                 345                 350         


Gly Lys Ser Val Gly Val Gly His Val Ala Arg Gly Ala Arg Asn Lys 
        355                 360                 365             


Pro Pro Leu Gly Pro Ala Ile Pro Ala Val Ser Pro Ser Ala His Leu 
    370                 375                 380                 


Ala Ala Ser Pro Ala Leu Leu Pro Ser Leu Ala Pro Leu Gly His Lys 
385                 390                 395                 400 


Lys His Lys His Arg Ala Lys Glu Ser Gln Gln Gly Cys Arg Gly Leu 
                405                 410                 415     


Gln Ala Pro Leu Ala Ser Gly Gly Pro Val Leu Gly Arg Glu His Leu 
            420                 425                 430         


Arg Glu Leu Pro Ala Leu Val Val Tyr Glu Ser Gln Ala Gly Gln Pro 
        435                 440                 445             


Val Gln Arg His Glu His His His His His Glu His His His His Tyr 
    450                 455                 460                 


His His Phe Tyr Gln Thr 
465                 470 

<210>  3217
<211>  1828
<212>  DNA
<213>  Homo sapiens

<400>  3217
ccaatgggcg cgcggggagg cgcgggccgc ggcggcgggc tgggggctcg gcgctcccgg     60

gcgtcagtcg ggccgcggcg acggcggcag gagcgcgtcc cggcgccgcc tcgggctccg    120

ctcggctcgg gggctgcttc gggaggagga gagccaaggg aggcgccagg cccgcgggcc    180

gggcgcatgg cttagggacg ctcccggccg ccgcagcccc agcatgggga aacttcactc    240

caagccggcc gccgtgtgca agcgcaggga gagcccggaa ggtgacagct tcgccgtgag    300

cgctgcctgg gctcggaagg gcatcgagga gtggatcggg agacagcgct gcccgggcgg    360

tgtctcggga ccccgacagc tgcggttggc gggcaccata ggccgaagca cccgggagct    420

cgtgggcgac gtgttgagag acacgctcag cgaggaagag gaggacgact ttcggctgga    480

agtggccctg cctcctgaga agactgacgg gctgggcagc ggagatgaga agaagatgga    540

gagagtgagc gaaccctgcc caggctccaa gaagcagctg aagtttgaag agctccagtg    600

cgacgtgtcc atggaggagg acagccggca ggagtggacc ttcaccctgt atgactttga    660

caacaacggc aaggtcaccc gagaggacat caccagcttg ctgcacacca tctatgaggt    720

ggtggactcc tctgtcaacc actccccaac atccagcaag atgctgcggg taaagctcac    780

cgtggccccc gatggcagcc agagcaagag gagcgtcctt gtcaatcagg ctgacctgca    840

gagcgcaagg ccccgagcag agaccaagcc cactgaggac ctgcggagct gggagaagaa    900

gcagcgagcc ccgctcaggt tccagggtga cagccgcctg gagcagtctg gctgctacca    960

ccattgcgta gatgagaaca tcgagaggag aaaccactac ttagatctcg ccgggataga   1020

aaactacacg tcccaatttg ggcctggctc cccttccgtg gcccagaagt cagaactgcc   1080

cccccgcacc tccaatccca ctcgatctcg ctcccatgag ccggaagcca tccacatccc   1140

acaccgaaag ccccaaggcg tggacccggc ctccttccac ttccttgaca ccccaatcgc   1200

caaggtctca gagctccagc aacggctccg gggcacccag gacgggagca agcactttgt   1260

gaggtccccc aaggcccagg gcaagagtgt gggtgtgggc cacgtggcca gaggggcaag   1320

aaacaagccc cctctgggac ccgccatccc tgcggtgtcc ccctccgccc acctggctgc   1380

cagcccggcc ctcctcccct ccctagcccc cctcgggcac aagaagcaca agcaccgagc   1440

caaggagagc cagcagggct gccggggcct gcaggcacca ctggcctcag gtggccctgt   1500

cctggggcgg gagcacctgc gggagctgcc cgccttggtg gtgtatgaga gccaggccgg   1560

gcagccggtc cagagacatg agcaccacca ccaccatgaa catcaccacc attaccacca   1620

cttctaccag acatagagcc cctccccagg gccccaccct gccatatgaa ggaccccacc   1680

cccgacacca caaggcatta ttattctatt aattattgtt attatgatga ttattgttat   1740

taataattat tgttactcca ctaatattta gctagcctac atgtagaaga tctatggaaa   1800

cacagaacta aacttttatt tatatgtt                                      1828


<210>  3218
<211>  470
<212>  PRT
<213>  Homo sapiens

<400>  3218


Met Gly Lys Leu His Ser Lys Pro Ala Ala Val Cys Lys Arg Arg Glu 
1               5                   10                  15      


Ser Pro Glu Gly Asp Ser Phe Ala Val Ser Ala Ala Trp Ala Arg Lys 
            20                  25                  30          


Gly Ile Glu Glu Trp Ile Gly Arg Gln Arg Cys Pro Gly Gly Val Ser 
        35                  40                  45              


Gly Pro Arg Gln Leu Arg Leu Ala Gly Thr Ile Gly Arg Ser Thr Arg 
    50                  55                  60                  


Glu Leu Val Gly Asp Val Leu Arg Asp Thr Leu Ser Glu Glu Glu Glu 
65                  70                  75                  80  


Asp Asp Phe Arg Leu Glu Val Ala Leu Pro Pro Glu Lys Thr Asp Gly 
                85                  90                  95      


Leu Gly Ser Gly Asp Glu Lys Lys Met Glu Arg Val Ser Glu Pro Cys 
            100                 105                 110         


Pro Gly Ser Lys Lys Gln Leu Lys Phe Glu Glu Leu Gln Cys Asp Val 
        115                 120                 125             


Ser Met Glu Glu Asp Ser Arg Gln Glu Trp Thr Phe Thr Leu Tyr Asp 
    130                 135                 140                 


Phe Asp Asn Asn Gly Lys Val Thr Arg Glu Asp Ile Thr Ser Leu Leu 
145                 150                 155                 160 


His Thr Ile Tyr Glu Val Val Asp Ser Ser Val Asn His Ser Pro Thr 
                165                 170                 175     


Ser Ser Lys Met Leu Arg Val Lys Leu Thr Val Ala Pro Asp Gly Ser 
            180                 185                 190         


Gln Ser Lys Arg Ser Val Leu Val Asn Gln Ala Asp Leu Gln Ser Ala 
        195                 200                 205             


Arg Pro Arg Ala Glu Thr Lys Pro Thr Glu Asp Leu Arg Ser Trp Glu 
    210                 215                 220                 


Lys Lys Gln Arg Ala Pro Leu Arg Phe Gln Gly Asp Ser Arg Leu Glu 
225                 230                 235                 240 


Gln Ser Gly Cys Tyr His His Cys Val Asp Glu Asn Ile Glu Arg Arg 
                245                 250                 255     


Asn His Tyr Leu Asp Leu Ala Gly Ile Glu Asn Tyr Thr Ser Gln Phe 
            260                 265                 270         


Gly Pro Gly Ser Pro Ser Val Ala Gln Lys Ser Glu Leu Pro Pro Arg 
        275                 280                 285             


Thr Ser Asn Pro Thr Arg Ser Arg Ser His Glu Pro Glu Ala Ile His 
    290                 295                 300                 


Ile Pro His Arg Lys Pro Gln Gly Val Asp Pro Ala Ser Phe His Phe 
305                 310                 315                 320 


Leu Asp Thr Pro Ile Ala Lys Val Ser Glu Leu Gln Gln Arg Leu Arg 
                325                 330                 335     


Gly Thr Gln Asp Gly Ser Lys His Phe Val Arg Ser Pro Lys Ala Gln 
            340                 345                 350         


Gly Lys Ser Val Gly Val Gly His Val Ala Arg Gly Ala Arg Asn Lys 
        355                 360                 365             


Pro Pro Leu Gly Pro Ala Ile Pro Ala Val Ser Pro Ser Ala His Leu 
    370                 375                 380                 


Ala Ala Ser Pro Ala Leu Leu Pro Ser Leu Ala Pro Leu Gly His Lys 
385                 390                 395                 400 


Lys His Lys His Arg Ala Lys Glu Ser Gln Gln Gly Cys Arg Gly Leu 
                405                 410                 415     


Gln Ala Pro Leu Ala Ser Gly Gly Pro Val Leu Gly Arg Glu His Leu 
            420                 425                 430         


Arg Glu Leu Pro Ala Leu Val Val Tyr Glu Ser Gln Ala Gly Gln Pro 
        435                 440                 445             


Val Gln Arg His Glu His His His His His Glu His His His His Tyr 
    450                 455                 460                 


His His Phe Tyr Gln Thr 
465                 470 

<210>  3219
<211>  2071
<212>  DNA
<213>  Homo sapiens

<400>  3219
ccaatgggcg cgcggggagg cgcgggccgc ggcggcgggc tgggggctcg gcgctcccgg     60

gcgtcagtcg ggccgcggcg acggcggcag gagcgcgtcc cggcgccgcc tcgggctccg    120

ctcggctcgg gggctgcttc gggaggagga gagccaaggg aggcgccagg cccgcgggcc    180

gggcgcatgg cttagggacg ctcccggccg ccgcagcccc agcatgggga aacttcactc    240

caagccggcc gccgtgtgca agcgcaggga gagcccggaa ggtgacagct tcgccgtgag    300

cgctgcctgg gctcggaagg gcatcgagga gtggatcggg agacagcgct gcccgggcgg    360

tgtctcggga ccccgacagc tgcggttggc gggcaccata ggccgaagca cccgggagct    420

cgtgggcgac gtgttgagag acacgctcag cgaggaagag gaggacgact ttcggctgga    480

agtggccctg cctcctgaga agactgacgg gctgggcagc ggagatgaga agaagatgga    540

gagagtgagc gaaccctgcc caggctccaa gaagcagctg aagtttgaag agctccagtg    600

cgacgtgtcc atggaggagg acagccggca ggagtggacc ttcaccctgt atgactttga    660

caacaacggc aaggtcaccc gagaggacat caccagcttg ctgcacacca tctatgaggt    720

ggtggactcc tctgtcaacc actccccaac atccagcaag atgctgcggg taaagctcac    780

cgtggccccc gatggcagcc agagcaagag gagcgtcctt gtcaatcagg ctgacctgca    840

gagcgcaagg ccccgagcag agaccaagcc cactgaggac ctgcggagct gggagaagaa    900

gcagcgagcc ccgctcaggt tccagggtga cagccgcctg gagcagtctg gctgctacca    960

ccattgcgta gatgagaaca tcgagaggag aaaccactac ttagatctcg ccgggataga   1020

aaactacacg tcccaatttg ggcctggctc cccttccgtg gcccagaagt cagaactgcc   1080

cccccgcacc tccaatccca ctcgatctcg ctcccatgag ccggaagcca tccacatccc   1140

acaccgaaag ccccaaggcg tggacccggc ctccttccac ttccttgaca ccccaatcgc   1200

caaggtctca gagctccagc aacggctccg gggcacccag gacgggagca agcactttgt   1260

gaggtccccc aaggcccagg gcaagagtgt gggtgtgggc cacgtggcca gaggggcaag   1320

aaacaagccc cctctgggac ccgccatccc tgcggtgtcc ccctccgccc acctggctgc   1380

cagcccggcc ctcctcccct ccctagcccc cctcgggcac aagaagcaca agcaccgagc   1440

caaggagagc cagcagggct gccggggcct gcaggcacca ctggcctcag gtggccctgt   1500

cctggggcgg gagcacctgc gggagctgcc cgccttggtg gtgtatgaga gccaggccgg   1560

gcagccggtc cagagacatg agcaccacca ccaccatgaa catcaccacc attaccacca   1620

cttctaccag acatagagcc cctccccagg gccccaccct gccatatgaa ggaccccacc   1680

cccgacacca caaggcatta ttattctatt aattattgtt attatgatga ttattgttat   1740

taataattat tgttactcca ctaatattta gctagcctac atgtagaaga tctatggaaa   1800

cacagaacta aacttttatt tatatgttgt ggggactgca taactagccc aggaaatgac   1860

tctggttttg agtggcctgt aatgggcaga ggctccctcg gggctcggga tctgcagcat   1920

ctatgtggat cagcccacac ccttcccaga gccagggagc ccttagcctc aactctgccc   1980

caccccagcc tcttccagga gagcaccctt acttggcccg gcttccagag accctcgaaa   2040

tctccgagaa gataaacagc tgctacctct t                                  2071


<210>  3220
<211>  470
<212>  PRT
<213>  Homo sapiens

<400>  3220


Met Gly Lys Leu His Ser Lys Pro Ala Ala Val Cys Lys Arg Arg Glu 
1               5                   10                  15      


Ser Pro Glu Gly Asp Ser Phe Ala Val Ser Ala Ala Trp Ala Arg Lys 
            20                  25                  30          


Gly Ile Glu Glu Trp Ile Gly Arg Gln Arg Cys Pro Gly Gly Val Ser 
        35                  40                  45              


Gly Pro Arg Gln Leu Arg Leu Ala Gly Thr Ile Gly Arg Ser Thr Arg 
    50                  55                  60                  


Glu Leu Val Gly Asp Val Leu Arg Asp Thr Leu Ser Glu Glu Glu Glu 
65                  70                  75                  80  


Asp Asp Phe Arg Leu Glu Val Ala Leu Pro Pro Glu Lys Thr Asp Gly 
                85                  90                  95      


Leu Gly Ser Gly Asp Glu Lys Lys Met Glu Arg Val Ser Glu Pro Cys 
            100                 105                 110         


Pro Gly Ser Lys Lys Gln Leu Lys Phe Glu Glu Leu Gln Cys Asp Val 
        115                 120                 125             


Ser Met Glu Glu Asp Ser Arg Gln Glu Trp Thr Phe Thr Leu Tyr Asp 
    130                 135                 140                 


Phe Asp Asn Asn Gly Lys Val Thr Arg Glu Asp Ile Thr Ser Leu Leu 
145                 150                 155                 160 


His Thr Ile Tyr Glu Val Val Asp Ser Ser Val Asn His Ser Pro Thr 
                165                 170                 175     


Ser Ser Lys Met Leu Arg Val Lys Leu Thr Val Ala Pro Asp Gly Ser 
            180                 185                 190         


Gln Ser Lys Arg Ser Val Leu Val Asn Gln Ala Asp Leu Gln Ser Ala 
        195                 200                 205             


Arg Pro Arg Ala Glu Thr Lys Pro Thr Glu Asp Leu Arg Ser Trp Glu 
    210                 215                 220                 


Lys Lys Gln Arg Ala Pro Leu Arg Phe Gln Gly Asp Ser Arg Leu Glu 
225                 230                 235                 240 


Gln Ser Gly Cys Tyr His His Cys Val Asp Glu Asn Ile Glu Arg Arg 
                245                 250                 255     


Asn His Tyr Leu Asp Leu Ala Gly Ile Glu Asn Tyr Thr Ser Gln Phe 
            260                 265                 270         


Gly Pro Gly Ser Pro Ser Val Ala Gln Lys Ser Glu Leu Pro Pro Arg 
        275                 280                 285             


Thr Ser Asn Pro Thr Arg Ser Arg Ser His Glu Pro Glu Ala Ile His 
    290                 295                 300                 


Ile Pro His Arg Lys Pro Gln Gly Val Asp Pro Ala Ser Phe His Phe 
305                 310                 315                 320 


Leu Asp Thr Pro Ile Ala Lys Val Ser Glu Leu Gln Gln Arg Leu Arg 
                325                 330                 335     


Gly Thr Gln Asp Gly Ser Lys His Phe Val Arg Ser Pro Lys Ala Gln 
            340                 345                 350         


Gly Lys Ser Val Gly Val Gly His Val Ala Arg Gly Ala Arg Asn Lys 
        355                 360                 365             


Pro Pro Leu Gly Pro Ala Ile Pro Ala Val Ser Pro Ser Ala His Leu 
    370                 375                 380                 


Ala Ala Ser Pro Ala Leu Leu Pro Ser Leu Ala Pro Leu Gly His Lys 
385                 390                 395                 400 


Lys His Lys His Arg Ala Lys Glu Ser Gln Gln Gly Cys Arg Gly Leu 
                405                 410                 415     


Gln Ala Pro Leu Ala Ser Gly Gly Pro Val Leu Gly Arg Glu His Leu 
            420                 425                 430         


Arg Glu Leu Pro Ala Leu Val Val Tyr Glu Ser Gln Ala Gly Gln Pro 
        435                 440                 445             


Val Gln Arg His Glu His His His His His Glu His His His His Tyr 
    450                 455                 460                 


His His Phe Tyr Gln Thr 
465                 470 

<210>  3221
<211>  508
<212>  DNA
<213>  Homo sapiens

<400>  3221
attccacctg aaatcacctg gaggatgcct ggagtgctgt tccacaccct gggctccccc     60

tgaagttctg actccttatc cctacctctg cagacacact ggctgggcca tctggggcca    120

aggttggtga aaacccaggc gtctgggtcc ccagcagcaa gaacaactcc caaggagaca    180

gaggccggcc ccctgcataa caactttgat ggctgcggcc caccctccaa ccacctgaca    240

catgtcatgc caacggctct gagcctcaca tcttcaaaaa ctggatgcca aggagaccca    300

ccaaaaacat gcgggtaaca tttgttatgg ctttgaagat aaaagtcaat tgaagtaagc    360

cctcgctgta tttcaagttt tccctctagc atggagcaag ctgcctggca gtttagaaaa    420

aaaagaaaag aaaaagaaaa aggagggact gcaaataaat gtcattctgc aggaatactt    480

tgtaaaaata aacaggctga aaaaaccc                                       508


<210>  3222
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  3222


Met Glu Gln Ala Ala Trp Gln Phe Arg Lys Lys Arg Lys Glu Lys Glu 
1               5                   10                  15      


Lys Gly Gly Thr Ala Asn Lys Cys His Ser Ala Gly Ile Leu Cys Lys 
            20                  25                  30          


Asn Lys Gln Ala Glu Lys 
        35              

<210>  3223
<211>  1138
<212>  DNA
<213>  Homo sapiens

<400>  3223
ctctgcccag cccaagctct cccagcctct gcctcccatc ccccaggagg aaagacagtg     60

cccaggctgg gccaggcagc tggccctggt gcccatgagc agaggggacc ctccctggag    120

aactcgaaaa tgccagtgaa caaggcccaa acacctccat cctgagtcct tctccagcct    180

taaagcaaat catcttttaa tcctgaaaca ccaaatattt aatttatgct ctacctcaaa    240

tgtcaagccc acctcccatc acatagcttt gaaaccacgt aaagaagcct aacactttcc    300

atatggcaaa gacatggggc cttttaattg tgccaactgg tatcattcaa gggtaattcc    360

cttggaatct ggcactcggg caacagctgg gccagcctcc aatctcatca cccaacccca    420

cacgtcccca tgggctccaa gaccctgcag gcaacttgga ctcatctggg acatttccca    480

agcccctcag acctcatcag gaaggaagag ggcaaacagg ggccactcct gcttctgcct    540

gccccacgac tggctcatct cgaagcaccc cctctctggg agttttgtat gtagcaccct    600

ccaggcggat gccctggcac agggcttctc tacaaatggc ttctcctaga aagtgctcca    660

gaaagggaga aacacacagt ccacaccagc gggctgtcaa cactacaagg ttatggggag    720

gattaagata atgtaagcaa agtgcttgac acatataggc acttaataaa tactagttat    780

cattgcaata acaataatac tagttggatg agccactgtg tctccagcca cttagttgac    840

aggccacgta aaggactaga ggcagagact agccccaaaa caggcctggg gttggtggga    900

ggacctctgc cagcccttgg aaaccagcag actttggagc ccatgccctc ctacatcctg    960

atgatatcat ggaagaacct accagctacc ccttcggcac cagagggaat cagggaaatg   1020

aactagcctg agggttgccc attgctgtcc tgttcaatat cttagtgctt cccaaacttg   1080

gggcattcca ttcccacatt cacaattttg accacttgta cttaatattt ttctctga     1138


<210>  3224
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  3224


Met Gly Pro Phe Asn Cys Ala Asn Trp Tyr His Ser Arg Val Ile Pro 
1               5                   10                  15      


Leu Glu Ser Gly Thr Arg Ala Thr Ala Gly Pro Ala Ser Asn Leu Ile 
            20                  25                  30          


Thr Gln Pro His Thr Ser Pro Trp Ala Pro Arg Pro Cys Arg Gln Leu 
        35                  40                  45              


Gly Leu Ile Trp Asp Ile Ser Gln Ala Pro Gln Thr Ser Ser Gly Arg 
    50                  55                  60                  


Lys Arg Ala Asn Arg Gly His Ser Cys Phe Cys Leu Pro His Asp Trp 
65                  70                  75                  80  


Leu Ile Ser Lys His Pro Leu Ser Gly Ser Phe Val Cys Ser Thr Leu 
                85                  90                  95      


Gln Ala Asp Ala Leu Ala Gln Gly Phe Ser Thr Asn Gly Phe Ser 
            100                 105                 110     

<210>  3225
<211>  446
<212>  DNA
<213>  Homo sapiens

<400>  3225
gttatggtag ggaaaaatgc tagcctggga gctgggtggt ctgcctcagt ttcctcatct     60

gtacaaaaag aggaagcatg gcaagagggt atctccaaag actttactgc tacaatagag    120

catgactcca caggctcagg agagggccaa ttcagccagg ccccaggctc cgttcctcct    180

ctgctgtctt caggccaccc agaagggcca ctgcccactt gcaaacctgg gcaacaaagt    240

gagactccat ctcaacaaca acaacaacaa aaaaaaggct taatgctaat ggccacaaac    300

tcataatggc agtaaaggag caaacggcat tgccaggtgg tgtggggccc agaccatgcc    360

cccacatggc ctgaggcttg ggtcctggct ctgtcaccta caggttgtgt gatgctgggc    420

aaactaataa acttctttgt acctta                                         446


<210>  3226
<211>  100
<212>  PRT
<213>  Homo sapiens

<400>  3226


Met Val Gly Lys Asn Ala Ser Leu Gly Ala Gly Trp Ser Ala Ser Val 
1               5                   10                  15      


Ser Ser Ser Val Gln Lys Glu Glu Ala Trp Gln Glu Gly Ile Ser Lys 
            20                  25                  30          


Asp Phe Thr Ala Thr Ile Glu His Asp Ser Thr Gly Ser Gly Glu Gly 
        35                  40                  45              


Gln Phe Ser Gln Ala Pro Gly Ser Val Pro Pro Leu Leu Ser Ser Gly 
    50                  55                  60                  


His Pro Glu Gly Pro Leu Pro Thr Cys Lys Pro Gly Gln Gln Ser Glu 
65                  70                  75                  80  


Thr Pro Ser Gln Gln Gln Gln Gln Gln Lys Lys Gly Leu Met Leu Met 
                85                  90                  95      


Ala Thr Asn Ser 
            100 

<210>  3227
<211>  2469
<212>  DNA
<213>  Homo sapiens

<400>  3227
actattaaag cctctccggt atctgacaca agtcagaatt tccactgttc cagctgagct     60

tttatgagga gcagacttga gagaaactgc caagattttc tggagtacac agggcacacg    120

gccagctgaa cacccgcttc ccccactcgc tgctgctggg aagagagcaa tggactccga    180

ataccttcca gccgaaagtc gtcctcctct tcctcgctga gcgtgtctct caacacgtcg    240

cccacgagct cctacaagaa gacagagcag aggcattgag caggggttgg gggagcccag    300

tgctgggacg ttaaaagcag tgccatgagg accctgggct gattcttctg attggaattc    360

aggtcaactg aggcagatcc tattgcacct gaaaagttaa gtgccaaggt gggtccctcc    420

tgcccttaac ataaacccac acgcatcagc acaacattca ggccaccaca ggctatggct    480

ccactgggtc ttccatcatg cctcccacat ttcaccaaca cacatgcctt ccggaaacca    540

gcctgattcc ttgcacacac cctgcctgtt ccccaccagt gagttaagga tatctgggat    600

ctcatcccaa ccaacctgac caggagatgt caagttagcg aggggagtgt tgctggtcca    660

caggctggga aatttctagg atgtcaacaa aggccccatc tgtctgaccc accctagcag    720

gataactcca aatatggaag aagctagacc ataccttgtc aaactgtctt ctgtatttat    780

tggtattctg ccagaagagt tctatgatca aagaagattc ttttaaacaa agttaaacaa    840

gatctcttac agcaggactt atcaggactt ttcctatggt tctaaacact gaatctccaa    900

gtgctggcat attttgcatt ctccaaactt atttagacca tggagcttcg tttttcaaaa    960

gtatcacatg atacgcgtgt cccaagaaac ccactttagg aaatactcct gttatgggag   1020

gacagacaag ggtttggggg atgatgatgc tatggtagcg gttctcaaaa cacaaaatga   1080

caagcaataa aaaagcccaa actcagcagc tgtcaccaac ttctctttgt gaaaataaaa   1140

gagaaaaaaa acaaaaacaa aaacaaaacc caaccctctc cttaggggaa aaaaaattct   1200

acacctcaga tgatgcttaa aaaaaaacca gtcctcttct tgatgaacaa aagaaaaaac   1260

acggctttgt attgctgatc tcatcaactg gacacagctg gaggtaagcc tcttgctttt   1320

ttttgttttt tgttttaaag acaaacagct aacattttgt ggctgttctc tttcttcttt   1380

caaatctttc tagggcatta cacactcttt cttaaaagct gttaaaatgt ggccattcag   1440

actccggtgt cccatttact tcaaaaccag gctactttat tcctcgagtc aggatggctt   1500

cctctcctcc tccaccaatt attataatca tcgaacatat cctgggcttg taaactggct   1560

gtttgtgtta acagagcccg agttgacagg ggagctggga gacgatgaca ggaaagggat   1620

gcacacaggt ggcatcatta gatggctggg acgccccagc agccaattga agcccatctt   1680

tcatgcagaa gagagacggg tgccaccgcc ccctgaaagg ctggtaggca gagcttcccc   1740

gagggaacag gcaacagtct tcaagagaat ctgcgcacct cttcatgctg aggtcttctg   1800

cagagcgggg ctctgcgcct gccaccctga ctgcactgca gccgggtgac agcatcaatg   1860

agacgtctga gtactcgtgt ctttttactg gcacacttgg aagagtttaa agactccaga   1920

catcgccacc aacaaggcag ccgtgtggga ccctatgaca atgaccgcat gtgctcaagg   1980

caccccagtc accacctaat gacagcttca gcactccctg ctcggagaac caagctctct   2040

gacacactca gaaagcagag ttctggcaag ttctggcata ggcctctcac cactcaacag   2100

taccctgctc tggagaacac tggaaagctc cccggagcca tggttcatgg acgcactgta   2160

ctgtgccaat gctcaacttt gcaaaaattc atctccccag ccaggcgcag tggctcacgc   2220

ctgtaatcct agcacttcgg gaggccgagg caggtggatc acgaggtcag gcaacctggc   2280

caacataatg aaaccccatc tctgctaaaa atacaaaaaa ttagccaggc gtagtggcag   2340

gtgactgtaa tcccaactac ttggggggct gaggcagaag aatcgcttga aactgggagg   2400

tggaggctgt ggtgagctga gattgcgcca ctgcactcca gcccaggtga cagtgtgaga   2460

ctctgtctc                                                           2469


<210>  3228
<211>  140
<212>  PRT
<213>  Homo sapiens

<400>  3228


Met Trp Pro Phe Arg Leu Arg Cys Pro Ile Tyr Phe Lys Thr Arg Leu 
1               5                   10                  15      


Leu Tyr Ser Ser Ser Gln Asp Gly Phe Leu Ser Ser Ser Thr Asn Tyr 
            20                  25                  30          


Tyr Asn His Arg Thr Tyr Pro Gly Leu Val Asn Trp Leu Phe Val Leu 
        35                  40                  45              


Thr Glu Pro Glu Leu Thr Gly Glu Leu Gly Asp Asp Asp Arg Lys Gly 
    50                  55                  60                  


Met His Thr Gly Gly Ile Ile Arg Trp Leu Gly Arg Pro Ser Ser Gln 
65                  70                  75                  80  


Leu Lys Pro Ile Phe His Ala Glu Glu Arg Arg Val Pro Pro Pro Pro 
                85                  90                  95      


Glu Arg Leu Val Gly Arg Ala Ser Pro Arg Glu Gln Ala Thr Val Phe 
            100                 105                 110         


Lys Arg Ile Cys Ala Pro Leu His Ala Glu Val Phe Cys Arg Ala Gly 
        115                 120                 125             


Leu Cys Ala Cys His Pro Asp Cys Thr Ala Ala Gly 
    130                 135                 140 

<210>  3229
<211>  1742
<212>  DNA
<213>  Homo sapiens

<400>  3229
ttcctttgtc tttgaagacc cacagaccac caggcacccc tgcaggcatc cctccccagg     60

ccaaacctcc cctgcccggg ctctggctgc cctcctgggc cagttctgtc ttggccaaag    120

tgctccctgt ccactcaagg tctggggagg gcagaggaca ggtggccgcc ccttggcctg    180

gcctctaggc ccaggcttcc actacccagt cagtgttgcc acagataggg gaccagcccc    240

gcccatctct ctgcatccag gagctccagt gcgacgtgtc catggaggag gacagccggc    300

aggagtggac cttcaccctg tatgactttg acaacaacgg caaggtcacc cgagaggaca    360

tcaccagctt gctgcacacc atctatgagg tggtggactc ctctgtcaac cactccccaa    420

catccagcaa gatgctgcgg gtaaagctca ccgtggcccc cgatggcagc cagagcaaga    480

ggagcgtcct tgtcaatcag gctgacctgc agagcgcaag gccccgagca gagaccaagc    540

ccactgagga cctgcggagc tgggagaaga agcagcgagc cccgctcagg ttccagggtg    600

acagccgcct ggagcagtct ggctgctacc accattgcgt agatgagaac atcgagagga    660

gaaaccacta cttagatctc gccgggatag aaaactacac gtcccaattt gggcctggct    720

ccccttccgt ggcccagaag tcagaactgc ccccccgcac ctccaatccc actcgatctc    780

gctcccatga gccggaagcc atccacatcc cacaccgaaa gccccaaggc gtggacccgg    840

cctccttcca cttccttgac accccaatcg ccaaggtctc agagctccag caacggctcc    900

ggggcaccca ggacgggagc aagcactttg tgaggtcccc caaggcccag ggcaagagtg    960

tgggtgtggg ccacgtggcc agaggggcaa gaaacaagcc ccctctggga cccgccatcc   1020

ctgcggtgtc cccctccgcc cacctggctg ccagcccggc cctcctcccc tccctagccc   1080

ccctcgggca caagaagcac aagcaccgag ccaaggagag ccagcagggc tgccggggcc   1140

tgcaggcacc actggcctca ggtggccctg tcctggggcg ggagcacctg cgggagctgc   1200

ccgccttggt ggtgtatgag agccaggccg ggcagccggt ccagagacat gagcaccacc   1260

accaccatga acatcaccac cattaccacc acttctacca gacatagagc ccctccccag   1320

ggccccaccc tgccatatga aggaccccac ccccgacacc acaaggcatt attattctat   1380

taattattgt tattatgatg attattgtta ttaataatta ttgttactcc actaatattt   1440

agctagccta catgtagaag atctatggaa acacagaact aaacttttat ttatatgttg   1500

tggggactgc ataactagcc caggaaatga ctctggtttt gagtggcctg taatgggcag   1560

aggctccctc ggggctcggg atctgcagca tctatgtgga tcagcccaca cccttcccag   1620

agccagggag cccttagcct caactctgcc ccaccccagc ctcttccagg agagcaccct   1680

tacttggccc ggcttccaga gaccctcgaa atctccgaga agataaacag ctgctacctc   1740

tt                                                                  1742


<210>  3230
<211>  341
<212>  PRT
<213>  Homo sapiens

<400>  3230


Met Glu Glu Asp Ser Arg Gln Glu Trp Thr Phe Thr Leu Tyr Asp Phe 
1               5                   10                  15      


Asp Asn Asn Gly Lys Val Thr Arg Glu Asp Ile Thr Ser Leu Leu His 
            20                  25                  30          


Thr Ile Tyr Glu Val Val Asp Ser Ser Val Asn His Ser Pro Thr Ser 
        35                  40                  45              


Ser Lys Met Leu Arg Val Lys Leu Thr Val Ala Pro Asp Gly Ser Gln 
    50                  55                  60                  


Ser Lys Arg Ser Val Leu Val Asn Gln Ala Asp Leu Gln Ser Ala Arg 
65                  70                  75                  80  


Pro Arg Ala Glu Thr Lys Pro Thr Glu Asp Leu Arg Ser Trp Glu Lys 
                85                  90                  95      


Lys Gln Arg Ala Pro Leu Arg Phe Gln Gly Asp Ser Arg Leu Glu Gln 
            100                 105                 110         


Ser Gly Cys Tyr His His Cys Val Asp Glu Asn Ile Glu Arg Arg Asn 
        115                 120                 125             


His Tyr Leu Asp Leu Ala Gly Ile Glu Asn Tyr Thr Ser Gln Phe Gly 
    130                 135                 140                 


Pro Gly Ser Pro Ser Val Ala Gln Lys Ser Glu Leu Pro Pro Arg Thr 
145                 150                 155                 160 


Ser Asn Pro Thr Arg Ser Arg Ser His Glu Pro Glu Ala Ile His Ile 
                165                 170                 175     


Pro His Arg Lys Pro Gln Gly Val Asp Pro Ala Ser Phe His Phe Leu 
            180                 185                 190         


Asp Thr Pro Ile Ala Lys Val Ser Glu Leu Gln Gln Arg Leu Arg Gly 
        195                 200                 205             


Thr Gln Asp Gly Ser Lys His Phe Val Arg Ser Pro Lys Ala Gln Gly 
    210                 215                 220                 


Lys Ser Val Gly Val Gly His Val Ala Arg Gly Ala Arg Asn Lys Pro 
225                 230                 235                 240 


Pro Leu Gly Pro Ala Ile Pro Ala Val Ser Pro Ser Ala His Leu Ala 
                245                 250                 255     


Ala Ser Pro Ala Leu Leu Pro Ser Leu Ala Pro Leu Gly His Lys Lys 
            260                 265                 270         


His Lys His Arg Ala Lys Glu Ser Gln Gln Gly Cys Arg Gly Leu Gln 
        275                 280                 285             


Ala Pro Leu Ala Ser Gly Gly Pro Val Leu Gly Arg Glu His Leu Arg 
    290                 295                 300                 


Glu Leu Pro Ala Leu Val Val Tyr Glu Ser Gln Ala Gly Gln Pro Val 
305                 310                 315                 320 


Gln Arg His Glu His His His His His Glu His His His His Tyr His 
                325                 330                 335     


His Phe Tyr Gln Thr 
            340     

<210>  3231
<211>  2256
<212>  DNA
<213>  Homo sapiens

<400>  3231
ttcctttgtc tttgaagacc cacagaccac caggcacccc tgcaggcatc cctccccagg     60

ccaaacctcc cctgcccggg ctctggctgc cctcctgggc cagttctgtc ttggccaaag    120

tgctccctgt ccactcaagg tctggggagg gcagaggaca ggtggccgcc ccttggcctg    180

gcctctaggc ccaggcttcc actacccagt cagtgttgcc acagataggg gaccagcccc    240

gcccatctct ctgcatccag gagctccagt gcgacgtgtc catggaggag gacagccggc    300

aggagtggac cttcaccctg tatgactttg acaacaacgg caaggtcacc cgagaggaca    360

tcaccagctt gctgcacacc atctatgagg tggtggactc ctctgtcaac cactccccaa    420

catccagcaa gatgctgcgg gtaaagctca ccgtggcccc cgatggcagc cagagcaaga    480

ggagcgtcct tgtcaatcag gctgacctgc agagcgcaag gccccgagca gagaccaagc    540

ccactgagga cctgcggagc tgggagaaga agcagcgagc cccgctcagg ttccagggtg    600

acagccgcct ggagcagtct ggctgctacc accattgcgt agatgagaac atcgagagga    660

gaaaccacta cttagatctc gccgggatag aaaactacac gtcccaattt gggcctggct    720

ccccttccgt ggcccagaag tcagaactgc ccccccgcac ctccaatccc actcgatctc    780

gctcccatga gccggaagcc atccacatcc cacaccgaaa gccccaaggc gtggacccgg    840

cctccttcca cttccttgac accccaatcg ccaaggtctc agagctccag caacggctcc    900

ggggcaccca ggacgggagc aagcactttg tgaggtcccc caaggcccag ggcaagagtg    960

tgggtgtggg ccacgtggcc agaggggcaa gaaacaagcc ccctctggga cccgccatcc   1020

ctgcggtgtc cccctccgcc cacctggctg ccagcccggc cctcctcccc tccctagccc   1080

ccctcgggca caagaagcac aagcaccgag ccaaggagag ccagcagggc tgccggggcc   1140

tgcaggcacc actggcctca ggtggccctg tcctggggcg ggagcacctg cgggagctgc   1200

ccgccttggt ggtgtatgag agccaggccg ggcagccggt ccagagacat gagcaccacc   1260

accaccatga acatcaccac cattaccacc acttctacca gacatagagc ccctccccag   1320

ggccccaccc tgccatatga aggaccccac ccccgacacc acaaggcatt attattctat   1380

taattattgt tattatgatg attattgtta ttaataatta ttgttactcc actaatattt   1440

agctagccta catgtagaag atctatggaa acacagaact aaacttttat ttatatgttg   1500

tggggactgc ataactagcc caggaaatga ctctggtttt gagtggcctg taatgggcag   1560

aggctccctc ggggctcggg atctgcagca tctatgtgga tcagcccaca cccttcccag   1620

agccagggag cccttagcct caactctgcc ccaccccagc ctcttccagg agagcaccct   1680

tacttggccc ggcttccaga gaccctcgaa atctccgaga agataaacag ctgctacctc   1740

ttagtattat tctgatttta ttttgccctt aactgattgt tatatgctac aagggatttc   1800

agtggactgc agagtgcgaa cgtcttgctg ttgtgttttt atgtcccaac ctagaaacct   1860

tagctgtctt ttctggagtt gtctttcatg cttttccagt gggatcaagc ccttttcccc   1920

aagagtccca tctcttctgc catgcacgac atgaaaatcc acttctcttc cttctccttc   1980

ttctctctct actttacagt gatacacaca cgtatttaag gactatccct gagaccatcc   2040

ttctcatttt ggaaactgct agggagggaa ccaaccactt aaacaagcgt ggttttccaa   2100

gatccaggca attgtgtgct gttggttgtg gtggaggatg tggcacatat atacgtacct   2160

acacggttct ctaacagagc tttctgtatc tatagataga tgccatctgt ccatttctat   2220

gtatctttct ataaatatac actctcaggt atcttt                             2256


<210>  3232
<211>  341
<212>  PRT
<213>  Homo sapiens

<400>  3232


Met Glu Glu Asp Ser Arg Gln Glu Trp Thr Phe Thr Leu Tyr Asp Phe 
1               5                   10                  15      


Asp Asn Asn Gly Lys Val Thr Arg Glu Asp Ile Thr Ser Leu Leu His 
            20                  25                  30          


Thr Ile Tyr Glu Val Val Asp Ser Ser Val Asn His Ser Pro Thr Ser 
        35                  40                  45              


Ser Lys Met Leu Arg Val Lys Leu Thr Val Ala Pro Asp Gly Ser Gln 
    50                  55                  60                  


Ser Lys Arg Ser Val Leu Val Asn Gln Ala Asp Leu Gln Ser Ala Arg 
65                  70                  75                  80  


Pro Arg Ala Glu Thr Lys Pro Thr Glu Asp Leu Arg Ser Trp Glu Lys 
                85                  90                  95      


Lys Gln Arg Ala Pro Leu Arg Phe Gln Gly Asp Ser Arg Leu Glu Gln 
            100                 105                 110         


Ser Gly Cys Tyr His His Cys Val Asp Glu Asn Ile Glu Arg Arg Asn 
        115                 120                 125             


His Tyr Leu Asp Leu Ala Gly Ile Glu Asn Tyr Thr Ser Gln Phe Gly 
    130                 135                 140                 


Pro Gly Ser Pro Ser Val Ala Gln Lys Ser Glu Leu Pro Pro Arg Thr 
145                 150                 155                 160 


Ser Asn Pro Thr Arg Ser Arg Ser His Glu Pro Glu Ala Ile His Ile 
                165                 170                 175     


Pro His Arg Lys Pro Gln Gly Val Asp Pro Ala Ser Phe His Phe Leu 
            180                 185                 190         


Asp Thr Pro Ile Ala Lys Val Ser Glu Leu Gln Gln Arg Leu Arg Gly 
        195                 200                 205             


Thr Gln Asp Gly Ser Lys His Phe Val Arg Ser Pro Lys Ala Gln Gly 
    210                 215                 220                 


Lys Ser Val Gly Val Gly His Val Ala Arg Gly Ala Arg Asn Lys Pro 
225                 230                 235                 240 


Pro Leu Gly Pro Ala Ile Pro Ala Val Ser Pro Ser Ala His Leu Ala 
                245                 250                 255     


Ala Ser Pro Ala Leu Leu Pro Ser Leu Ala Pro Leu Gly His Lys Lys 
            260                 265                 270         


His Lys His Arg Ala Lys Glu Ser Gln Gln Gly Cys Arg Gly Leu Gln 
        275                 280                 285             


Ala Pro Leu Ala Ser Gly Gly Pro Val Leu Gly Arg Glu His Leu Arg 
    290                 295                 300                 


Glu Leu Pro Ala Leu Val Val Tyr Glu Ser Gln Ala Gly Gln Pro Val 
305                 310                 315                 320 


Gln Arg His Glu His His His His His Glu His His His His Tyr His 
                325                 330                 335     


His Phe Tyr Gln Thr 
            340     

<210>  3233
<211>  5214
<212>  DNA
<213>  Homo sapiens

<400>  3233
agccactgtt atgcaaagtt caagggcctc tctcacactt agctggggga ggagtgaata     60

cagcctttct gaagaaagaa aaattaagta atagcaaaat cattaagtgt ttatgattca    120

taaatacagt ttttgtcaac taaaaaaata aaatatgtag aagtcaaaaa agtgtctatg    180

attcagaaat gccaccgtta gaagttgcca taagagtgca cacaaaaagg acatatgggt    240

caaagtgttt gcagcagtgt tgtcccaaat aaggacattt tgcaacattg tggggtggtt    300

aaaataacta tagaatatgc attagaatac aatgaaacca ttaaacataa tgtggaagaa    360

tattgtatat tatagggaaa tgctcataat atatagtgac aatttaaaaa gcagattaca    420

aaacaatatg ccaagacatg atttctgccc aagtctgccc tgatgggtga gctaaccaag    480

gttgctgcac tgtgagggca taggggctgc ccctcagccc ccaccccagc cactgggctc    540

ctcaggaaag gacacgtgag tgtttactgc acatcctaca gatgaggagc tcacaaggac    600

cctggatggg ggagtcctct gaggttgctg gagctgctgc agccatcttg tcactgccag    660

gggagagctc tctctgagag cgaaggcaca gtggaggaaa gcagaactaa gaagagacag    720

agaaagcgaa agtgggagag agagagagat atgaggtgac aagtgtgggt ccttggatcc    780

tgcttggtgt aaagctagcc tgctcctgga ctttacagat aataaattcc ttcctcatca    840

gattaacctg ggtttttgtg gcttgtaacc aaaagggtct gcacggccca cacacaggct    900

cccagctcat ttcctttgca atgagtggta actggaggcg ggcggtgcat ggacctgcct    960

tgcaaggctt ctctgttagt ggtgcctgga gcccactctc tcagctggca cagccagtgt   1020

gacacatcag tccgggtgtg tcctggacct accccctttc tgggtgcaaa ccagaactga   1080

ggatgccgag ggtggtgggg gggtagtttc ctgcctcagg gctgtgctcc tgctacctct   1140

ttgcctaaaa ttctcccctc tctgtgctcc cagggccagc tcctttgtat gctctgtgat   1200

tctttgaaca gcgccccctc tgagaagcct tccctgacca cctggctgag gacatcattc   1260

tgtcccagct tccatttgct ttgggagtgg cctcctgaca cttcacttcc gtgaggcagg   1320

gaccagttct gtcctggtca ctgctgtatc cccagctcta gataaggcct gagacatcgt   1380

aggagtgcca gggatctttg gttactgaga aaacgagcag ctagatcaag gttcccaaca   1440

ccaacacgct ggggacatgt tgggagtcaa cttagcccta ccagcaggtg gaactagttt   1500

tgctgctcca aaacagagtt ctagctatgg ggacagccac tagagagcag agctaagtcc   1560

atgctatgct gaggggccac agtctgccct gaactgtgcc tcccagcctg gagctagtga   1620

gggggccgag cctgggagct gacagatgag ggctcggcgt ggggactttt ggaggggagg   1680

gcattttctt gatcttacca tgggggcaac agctagatgg gtaggggggg acccactcaa   1740

ggacatactg cggcttcagg cttcgaccag cccagaacgc tcgctccatc tgagggtctt   1800

gatatcaggg tgtggcgtca ggagccggag cctacgggtt gaaagccaag agtgggcaat   1860

caaagctgaa accaggccca cgacttagga gctggagagc acacagggct gaacactcga   1920

gttggtgacc aggaaaccag ggagcaaagt ctccagggtg cttgggcaag accccagatg   1980

gtctgcagca acgcacgggc aacacgggat gatcagcgct acgtggtgag aaacttacct   2040

ccttttgcag gacaacattt tccagtcctt ctgagtaaat caaagagaag tctcagcttg   2100

gtgattgcag gtctctaatg cttatttctc tgtctctgtc tctctctctt ttaacaaaag   2160

tctaccagcg gcctcaggct cagggcctgt ctcaggtaaa agcgggttag ggtgtaataa   2220

cagtgatcgg tttcattgtg tttatttttg tagctacttt ctaattatag caagtgattc   2280

tgagtttcca tttaggatag taataggaag tttctttttc aagtaaatgt gcataagtaa   2340

aaggagactg ctcaaaggaa aacagctggt gattgataga acaggctgtg gcattgttgg   2400

gccccagagg gaagggctgt gtgagcatgc aggaaattct gggaaggcag ctaaatgcag   2460

ttgctgcatg ggggccagga agcatttgga gacgtggctg ggcacagctt ggcttttgag   2520

cccaagagag gcctgctggg gatgtgttgg gagccaacct acccctacca gcaggtggaa   2580

ctggttttgc cactccaaaa cagagttcca gctatgggga cagccactag agagcagagc   2640

taagggcatt ctaggccaag gggtcacagt ccaccctgaa ctgtgcctcc cagcctgaag   2700

ccagaaagct cagggaggct agcggccctg cccaggcctc agcactgacc ctgcacccct   2760

aggcccagct ggatgacccc taagagcttc ctggaatttg gatgcagggt tattctgtgt   2820

gtgctgcctc tcagagcatg tcactttgac gtggacatct cgggtctggt tctggtgctg   2880

tccctgtctc gccacgtgac cctggataag tcatctctcc aggccttgat ttccccatct   2940

gtaaacagag gtgagtgaaa tgatctttaa aggcgtgtca gtccattttg cattgctata   3000

aaggaatacc tgaggttggg tagcttataa agaaaagagg gttatttggc tcacagttgt   3060

gcaggttgta cagaagcatg gcaccagcat tgcttcttgt gaagcttcag gaagcttcca   3120

cttatggtgg aaggggaagg gggagttcgt gacttacatg gcaagagagg gagcaagagc   3180

catgtcaggc tcttctaaac aaccagctct catgtaaact aacagagtga gaactcattc   3240

attaccacgg ggagggcacc aagccatcca tgagggacct gcccccatga gccaaacatc   3300

tcccaccagg ccacaccttc aacactggga gtcacattca gcatgagatt tggaggtgac   3360

caccatgcat ccaaaccata tcaaggaccc atttcggtga ggggaccagg aacatatccc   3420

ttcccctctc ctccacatcc tttaatgtgg agttcagcaa ggaaagtagg gcttgggtca   3480

aattaaagcc tggtcttaat ttcctggtcc agttattagc tgtgtaaccc tgggcaagtc   3540

acttaacccc ctcaggttac aatgttacaa atgatcacat tttcctcaac tgaaaaatgg   3600

gataggaaca tgtcccaagc agagctggag tgacggtgct atcaatggcc cggcagtgcc   3660

tggtcacaca gtaggcctgg ggagccctga cttttaccgc acagggagct gcttgcagag   3720

cttgttttca attgtgggct tggcagggaa ctgccggcat cccaggggac agggtctcat   3780

gaggatgcct aatcccagct caaagtggag accccaggac tccatcacag ccagtggggg   3840

ggagtggctg ctgcagcagg gagggcttca ttggaatgaa cccctttaag ctccagtcca   3900

aatgcccaga gtggttttgc aggtatggtt gtgaggctgg catggtagtc ccatctgcag   3960

tcccctggga tgaggcacct gtatggtaga gggcccgggt ggagagaaga gaaggatggg   4020

gatgaaccca ggaccacaga tggcccagtt ccatggatga ttttcattga ggtgccttca   4080

agtcagttca acactgggct tctcaacctt tgaggtatgc aggtaagagt cacctgcggc   4140

agtgggggat gctcttgtta aagtgcagac tccgattaag caggtctagg gtggggcctg   4200

aaattctgtg ttcctaacaa ggctccatcc tgggtatgga ggtcaggtac cccctcacct   4260

ctcctgtgga cccagctttt gaggggtcag gagaagaatg ttcagtccca gctgccacca   4320

ctctaaagtc ccctagaaac aaggactaat acaggtggcg tgggagaggg cccaggcaaa   4380

cagggaggtg gggtaccccg gtggggctgc agtgggccct gcggaaagct tgctggaggt   4440

gggggcctaa ggaattcaag gacttgttcc aggaacccaa ggaacgagtg ggctctaact   4500

gctgcagcat atgggagatg ccaggaggag ctggctgtgg caggccatcc cagtccatca   4560

gacaacttgt agtggatgaa gatgcagtgt ccatggccag aagaaactcc cgtggatgct   4620

caggccaagg ctgccagaag cacgaggagg ggcagcattg agtgtcatcg ggaaaaggca   4680

aagtgatggt cctgaagctg ccccatgtgg ccagtccctt tttgggaagc ctgaataaat   4740

ccatttcctg tgcactgtgt gggaagccaa cccctcttca gagcacctct gaactcaaca   4800

ggatcctaca cttcttatag gcctggcttg atgctgacat ccttcagccc cagggaagac   4860

ctaaagatct ccaggtcttg aggcacctgg aacacctcca cctgagacca ctttaacatg   4920

atttctctgc ttgagggatt ttggaccatg ctgtgtgtat tcagccctaa aacatgggcg   4980

agtgcccgct tgcagttcaa attctcagag gaagttccct gtactccacc cagtgccaag   5040

tttagtttgt gcaaatttcc ttaatgtccc ctcctgtaca acaggcttat ttggtgttaa   5100

ccctcatatc gggggtctaa ctctttgctt ttccagcttt tgtgctggaa tatcccatta   5160

aactgtccat gttgggtatt ttttctttgt tagtaaacat ttgttgcata ttgt         5214


<210>  3234
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  3234


Met Val Leu Lys Leu Pro His Val Ala Ser Pro Phe Leu Gly Ser Leu 
1               5                   10                  15      


Asn Lys Ser Ile Ser Cys Ala Leu Cys Gly Lys Pro Thr Pro Leu Gln 
            20                  25                  30          


Ser Thr Ser Glu Leu Asn Arg Ile Leu His Phe Leu 
        35                  40                  

<210>  3235
<211>  2197
<212>  DNA
<213>  Homo sapiens

<400>  3235
gggcgatcag aagcaggtca cacagcctgt ttcctgtttt caaacgggga acttagaaag     60

tggcagcccc tcggcttgtc gccggagctg agaaccaaga gctcgaaggg gccatatgac    120

actcctcccg gacccctgga cacacacagc cctggagact ggagccttgg agcatggcaa    180

gtccagagca ccctgggagc cctggctgca tgggacccat aacccagtgc acggcaagga    240

cccagcagga agcaccagcc actggccccg acctcccgca cccaggacct gacgggcact    300

tagacacaca cagtggcctg agctccaact ccagcatgac cacgcgggag cttcagcagt    360

actggcagaa ccagaaatgc cgctggaagc acgtcaaact gctctttgag atcgcttcag    420

ctcgcatcga ggagagaaaa gtctctaagt ttgtggctcc ggctcctgac gccacaccct    480

gatatcaaga ccctcagatg gagcgagcgt tctgggctgg tcgaagcctg aagccgcagt    540

atgtccttga gtgggtcccc ccctacccat ctagctgttg cccccatggt aagatcaaga    600

aaatgccctc ccctccaaaa gtccccacgc cgagccctca tctgtcagct cccaggctcg    660

gccccctcac tagctccagg ctgggaggca cagttcaggg cagactgtgg cccctcagca    720

tagcatggac ttagctctgc tctctagtgg ctgtccccat agctagaact ctgttttgga    780

gcagcaaaac tagttccacc tgctggtagg gctaagttga ctcccaacat gtccccagcg    840

tgttggtgtt gggaaccttg atctagctgc tcgttttctc agtaaccaaa gatccctggc    900

actcctacga tgtctcaggc cttatctaga gctggggata cagcagtgac caggacagaa    960

ctggtccctg cctcacggaa gtgaagtgtc aggaggccac tcccaaagca aatggaagct   1020

gggacagaat gatgtcctca gccaggtggt cagggaaggc ttctcagagg gggcgctgtt   1080

caaagaatca cagagcatac aaaggagctg gccctgggag cacagagagg ggagaatttt   1140

aggcaaagag gtagcaggag cacagccctg aggcaggaaa ctaccccccc accaccctcg   1200

gcatcctcag ttctggtttg cacccagaaa gggggtaggt ccaggacaca cccggactga   1260

tgtgtcacac tggctgtgcc agctgagaga gtgggctcca ggcaccacta acagagaagc   1320

cttgcaaggc aggtccatgc accgcccgcc tccagttacc actcattgca aaggaaatga   1380

gctgggagcc tgtgtgtggg ccgtgcagac ccttttggtt acaagccaca aaaacccagg   1440

ttaatctgat gaggaaggaa tttattatct gtaaagtcca ggagcaggct agctttacac   1500

caagcaggat ccaaggaccc acacttgtca cctcatatct ctctctctct cccactttcg   1560

ctttctctgt ctcttcttag ttctgctttc ctccactgtg ccttcgctct cagagagagc   1620

tctcccctgg cagtgacaag atggctgcag cagctccagc aacctcagag gactccccca   1680

tccagggtcc ttgtgagctc ctcatctgta ggatgtgcag taaacactca cgtgtccttt   1740

cctgaggagc ccagtggctg gggtgggggc tgaggggcag cccctatgcc ctcacagtgc   1800

agcaaccttg gttagctcac ccatcagggc agacttgggc agaaatcatg tcttggcata   1860

ttgttttgta atctgctttt taaattgtca ctatatatta tgagcatttc cctataatat   1920

acaatattct tccacattat gtttaatggt ttcattgtat tctaatgcat attctatagt   1980

tattttaacc accccacaat gttgcaaaat gtccttattt gggacaacac tgctgcaaac   2040

actttgaccc atatgtcctt tttgtgtgca ctcttatggc aacttctaac ggtggcattt   2100

ctgaatcata gacacttttt tgacttctac atattttatt tttttagttg acaaaaactg   2160

tatttatgaa tcataaacac ttaatgattt tgctatt                            2197


<210>  3236
<211>  102
<212>  PRT
<213>  Homo sapiens

<400>  3236


Met Ala Ser Pro Glu His Pro Gly Ser Pro Gly Cys Met Gly Pro Ile 
1               5                   10                  15      


Thr Gln Cys Thr Ala Arg Thr Gln Gln Glu Ala Pro Ala Thr Gly Pro 
            20                  25                  30          


Asp Leu Pro His Pro Gly Pro Asp Gly His Leu Asp Thr His Ser Gly 
        35                  40                  45              


Leu Ser Ser Asn Ser Ser Met Thr Thr Arg Glu Leu Gln Gln Tyr Trp 
    50                  55                  60                  


Gln Asn Gln Lys Cys Arg Trp Lys His Val Lys Leu Leu Phe Glu Ile 
65                  70                  75                  80  


Ala Ser Ala Arg Ile Glu Glu Arg Lys Val Ser Lys Phe Val Ala Pro 
                85                  90                  95      


Ala Pro Asp Ala Thr Pro 
            100         

<210>  3237
<211>  3304
<212>  DNA
<213>  Homo sapiens

<400>  3237
gggcgatcag aagcaggtca cacagcctgt ttcctgtttt caaacgggga acttagaaag     60

tggcagcccc tcggcttgtc gccggagctg agaaccaaga gctcgaaggg gccatatgac    120

actcctcccg gacccctgga cacacacagc cctggagact ggagccttgg agcatggcaa    180

gtccagagca ccctgggagc cctggctgca tgggacccat aacccagtgc acggcaagga    240

cccagcagga agcaccagcc actggccccg acctcccgca cccaggacct gacgggcact    300

tagacacaca cagtggcctg agctccaact ccagcatgac cacgcgggag cttcagcagt    360

actggcagaa ccagaaatgc cgctggaagc acgtcaaact gctctttgag atcgcttcag    420

ctcgcatcga ggagagaaaa gtctctaagt ttgtgatggg gaaatcaagg cctggagaga    480

tgacttatcc agggtcacgt ggcgagacag ggacagcacc agaaccagac ccgagatgtc    540

cacgtcaaag tgacatgctc tgagaggcag cacacacaga ataaccctgc atccaaattc    600

caggaagctc ttaggggtca tccagctggg cctaggggtg cagggtcagt gctgaggcct    660

gggcagggcc gctagcctcc ctgagctttc tggcttcagg ctgggaggca cagttcaggg    720

tggactgtga ccccttggcc tagaatgccc ttagctctgc tctctagtgg ctgtccccat    780

agctggaact ctgttttgga gtggcaaaac cagttccacc tgctggtagg ggtaggttgg    840

ctcccaacac atccccagca ggcctctctt gggctcaaaa gccaagctgt gcccagccac    900

gtctccaaat gcttcctggc ccccatgcag caactgcatt tagctgcctt cccagaattt    960

cctgcatgct cacacagccc ttccctctgg ggcccaacaa tgccacagcc tgttctatca   1020

atcaccagct gttttccttt gagcagtctc cttttactta tgcacattta cttgaaaaag   1080

aaacttccta ttactatcct aaatggaaac tcagaatcac ttgctataat tagaaagtag   1140

ctacaaaaat aaacacaatg aaaccgatca ctgttattac accctaaccc gcttttacct   1200

gagacaggcc ctgagcctga ggccgctggt agacttttgt taaaagagag agagacagag   1260

acagagaaat aagcattaga gacctgcaat caccaagctg agacttctct ttgatttact   1320

cagaaggact ggaaaatgtt gtcctgcaaa aggaggtaag tttctcacca cgtagcgctg   1380

atcatcccgt gttgcccgtg cgttgctgca gaccatctgg ggtcttgccc aagcaccctg   1440

gagactttgc tccctggttt cctggtcacc aactcgagtg ttcagccctg tgtgctctcc   1500

agctcctaag tcgtgggcct ggtttcagct ttgattgccc actcttggct ttcaacccgt   1560

aggctccggc tcctgacgcc acaccctgat atcaagaccc tcagatggag cgagcgttct   1620

gggctggtcg aagcctgaag ccgcagtatg tccttgagtg ggtccccccc tacccatcta   1680

gctgttgccc ccatggtaag atcaagaaaa tgccctcccc tccaaaagtc cccacgccga   1740

gccctcatct gtcagctccc aggctcggcc ccctcactag ctccaggctg ggaggcacag   1800

ttcagggcag actgtggccc ctcagcatag catggactta gctctgctct ctagtggctg   1860

tccccatagc tagaactctg ttttggagca gcaaaactag ttccacctgc tggtagggct   1920

aagttgactc ccaacatgtc cccagcgtgt tggtgttggg aaccttgatc tagctgctcg   1980

ttttctcagt aaccaaagat ccctggcact cctacgatgt ctcaggcctt atctagagct   2040

ggggatacag cagtgaccag gacagaactg gtccctgcct cacggaagtg aagtgtcagg   2100

aggccactcc caaagcaaat ggaagctggg acagaatgat gtcctcagcc aggtggtcag   2160

ggaaggcttc tcagaggggg cgctgttcaa agaatcacag agcatacaaa ggagctggcc   2220

ctgggagcac agagagggga gaattttagg caaagaggta gcaggagcac agccctgagg   2280

caggaaacta cccccccacc accctcggca tcctcagttc tggtttgcac ccagaaaggg   2340

ggtaggtcca ggacacaccc ggactgatgt gtcacactgg ctgtgccagc tgagagagtg   2400

ggctccaggc accactaaca gagaagcctt gcaaggcagg tccatgcacc gcccgcctcc   2460

agttaccact cattgcaaag gaaatgagct gggagcctgt gtgtgggccg tgcagaccct   2520

tttggttaca agccacaaaa acccaggtta atctgatgag gaaggaattt attatctgta   2580

aagtccagga gcaggctagc tttacaccaa gcaggatcca aggacccaca cttgtcacct   2640

catatctctc tctctctccc actttcgctt tctctgtctc ttcttagttc tgctttcctc   2700

cactgtgcct tcgctctcag agagagctct cccctggcag tgacaagatg gctgcagcag   2760

ctccagcaac ctcagaggac tcccccatcc agggtccttg tgagctcctc atctgtagga   2820

tgtgcagtaa acactcacgt gtcctttcct gaggagccca gtggctgggg tgggggctga   2880

ggggcagccc ctatgccctc acagtgcagc aaccttggtt agctcaccca tcagggcaga   2940

cttgggcaga aatcatgtct tggcatattg ttttgtaatc tgctttttaa attgtcacta   3000

tatattatga gcatttccct ataatataca atattcttcc acattatgtt taatggtttc   3060

attgtattct aatgcatatt ctatagttat tttaaccacc ccacaatgtt gcaaaatgtc   3120

cttatttggg acaacactgc tgcaaacact ttgacccata tgtccttttt gtgtgcactc   3180

ttatggcaac ttctaacggt ggcatttctg aatcatagac acttttttga cttctacata   3240

ttttattttt ttagttgaca aaaactgtat ttatgaatca taaacactta atgattttgc   3300

tatt                                                                3304


<210>  3238
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  3238


Met Ala Ser Pro Glu His Pro Gly Ser Pro Gly Cys Met Gly Pro Ile 
1               5                   10                  15      


Thr Gln Cys Thr Ala Arg Thr Gln Gln Glu Ala Pro Ala Thr Gly Pro 
            20                  25                  30          


Asp Leu Pro His Pro Gly Pro Asp Gly His Leu Asp Thr His Ser Gly 
        35                  40                  45              


Leu Ser Ser Asn Ser Ser Met Thr Thr Arg Glu Leu Gln Gln Tyr Trp 
    50                  55                  60                  


Gln Asn Gln Lys Cys Arg Trp Lys His Val Lys Leu Leu Phe Glu Ile 
65                  70                  75                  80  


Ala Ser Ala Arg Ile Glu Glu Arg Lys Val Ser Lys Phe Val Met Gly 
                85                  90                  95      


Lys Ser Arg Pro Gly Glu Met Thr Tyr Pro Gly Ser Arg Gly Glu Thr 
            100                 105                 110         


Gly Thr Ala Pro Glu Pro Asp Pro Arg Cys Pro Arg Gln Ser Asp Met 
        115                 120                 125             


Leu 
    

<210>  3239
<211>  2053
<212>  DNA
<213>  Homo sapiens

<400>  3239
gggcgatcag aagcaggtca cacagcctgt ttcctgtttt caaacgggga acttagaaag     60

tggcagcccc tcggcttgtc gccggagctg agaaccaaga gctcgaaggg gccatatgac    120

actcctcccg gacccctgga cacacacagc cctggagact ggagccttgg agcatggcaa    180

gtccagagca ccctgggagc cctggctgca tgggacccat aacccagtgc acggcaagga    240

cccagcagga agcaccagcc actggccccg acctcccgca cccaggacct gacgggcact    300

tagacacaca cagtggcctg agctccaact ccagcatgac cacgcgggag cttcagcagt    360

actggcagaa ccagaaatgc cgctggaagc acgtcaaact gctctttgag atcgcttcag    420

ctcgcatcga ggagagaaaa gtctctaagt ttgtgatggg gaaatcaagg cctggagaga    480

tgacttatcc agggtcacgt ggcgagacag ggacagcacc agaaccagac ccgagatgtc    540

cacgtcaaag tgacatgctc tgagaggcag cacacacaga ataaccctgc atccaaattc    600

caggaagctc ttaggggtca tccagctggg cctaggggtg cagggtcagt gctgaggcct    660

gggcagggcc gctagcctcc ctgagctttc tggcttcagg ctgggaggca cagttcaggg    720

tggactgtga ccccttggcc tagaatgccc ttagctctgc tctctagtgg ctgtccccat    780

agctggaact ctgttttgga gtggcaaaac cagttccacc tgctggtagg ggtaggttgg    840

ctcccaacac atccccagca ggcctctctt gggctcaaaa gccaagctgt gcccagccac    900

gtctccaaat gcttcctggc ccccatgcag caactgcatt tagctgcctt cccagaattt    960

cctgcatgct cacacagccc ttccctctgg ggcccaacaa tgccacagcc tgttctatca   1020

atcaccagct gttttccttt gagcagtctc cttttactta tgcacattta cttgaaaaag   1080

aaacttccta ttactatcct aaatggaaac tcagaatcac ttgctataat tagaaagtag   1140

ctacaaaaat aaacacaatg aaaccgatca ctgttattac accctaaccc gcttttacct   1200

gagacaggcc ctgagcctga ggccgctggt agacttttgt taaaagagag agagacagag   1260

acagagaaat aagcattaga gacctgcaat caccaagctg agacttctct ttgatttact   1320

cagaaggact ggaaaatgtt gtcctgcaaa aggaggtaag tttctcacca cgtagcgctg   1380

atcatcccgt gttgcccgtg cgttgctgca gaccatctgg ggtcttgccc aagcaccctg   1440

gagactttgc tccctggttt cctggtcacc aactcgagtg ttcagccctg tgtgctctcc   1500

agctcctaag tcgtgggcct ggtttcagct ttgattgccc actcttggct ttcaacccgt   1560

aggctccggc tcctgacgcc acaccctgat atcaagaccc tcagatggag cgagcgttct   1620

gggctggtcg aagcctgaag ccgcagtatg tccttgagtg ggtccccccc tacccatcta   1680

gctgttgccc ccatgttctg ctttcctcca ctgtgccttc gctctcagag agagctctcc   1740

cctggcagtg acaagatggc tgcagcagct ccagcaacct cagaggactc ccccatccag   1800

ggtccttgtg agctcctcat ctgtaggatg tgcagtaaac actcacgtgt cctttcctga   1860

ggagcccagt ggctggggtg ggggctgagg ggcagcccct atgccctcac agtgcagcaa   1920

ccttggttag ctcacccatc agggcagact tgggcagaaa tcatgtcttg gcatattgtt   1980

ttgtaatctg ctttttaaat tgtcactata tattatgagc atttccctat aatatacaat   2040

attcttccac att                                                      2053


<210>  3240
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  3240


Met Ala Ser Pro Glu His Pro Gly Ser Pro Gly Cys Met Gly Pro Ile 
1               5                   10                  15      


Thr Gln Cys Thr Ala Arg Thr Gln Gln Glu Ala Pro Ala Thr Gly Pro 
            20                  25                  30          


Asp Leu Pro His Pro Gly Pro Asp Gly His Leu Asp Thr His Ser Gly 
        35                  40                  45              


Leu Ser Ser Asn Ser Ser Met Thr Thr Arg Glu Leu Gln Gln Tyr Trp 
    50                  55                  60                  


Gln Asn Gln Lys Cys Arg Trp Lys His Val Lys Leu Leu Phe Glu Ile 
65                  70                  75                  80  


Ala Ser Ala Arg Ile Glu Glu Arg Lys Val Ser Lys Phe Val Met Gly 
                85                  90                  95      


Lys Ser Arg Pro Gly Glu Met Thr Tyr Pro Gly Ser Arg Gly Glu Thr 
            100                 105                 110         


Gly Thr Ala Pro Glu Pro Asp Pro Arg Cys Pro Arg Gln Ser Asp Met 
        115                 120                 125             


Leu 
    

<210>  3241
<211>  1108
<212>  DNA
<213>  Homo sapiens

<400>  3241
ggcattctag gccaaggggt cacagtccac cctgaactgt gcctcccagc ctgaagccag     60

aaagctcagg gaggctagcg gccctgccca ggcctcagca ctgaccctgc acccctaggc    120

ccagctggat gacccctaag agcttcctgg aatttggatg cagggttatt ctgtgtgtgc    180

tgcctctcag agcatgtcac tttgacgtgg acatctcggg tctggttctg gtgctgtccc    240

tgtctcgcca cgtgaccctg gataagtcat ctctccaggc cttgatttcc ccatctgtaa    300

acagaggaac ccaaggaacg agtgggctct aactgctgca gcatatggga gatgccagga    360

ggagctggct gtggcaggcc atcccagtcc atcagacaac ttgtagtgga tgaagatgca    420

gtgtccatgg ccagaagaaa ctcccgtgga tgctcaggcc aaggctgcca gaagcacgag    480

gaggggcagc attgagtgtc atcgggaaaa ggcaaagtga tggtcctgaa gctgccccat    540

gtggccagtc cctttttggg aagcctgaat aaatccattt cctgtgcact gtgtgggaag    600

ccaacccctc ttcagagcac ctctgaactc aacaggatcc tacacttctt ataggcctgg    660

cttgatgctg acatccttca gccccaggga agacctaaag atctccaggt cttgaggcac    720

ctggaacacc tccacctgag accactttaa catgatttct ctgcttgagg gattttggac    780

catgctgtgt gtattcagcc ctaaaacatg ggcgagtgcc cgcttgcagt tcaaattctc    840

agaggaagtt ccctgtactc cacccagtgc caagtttagt ttgtgcaaat ttccttaatg    900

tcccctcctg tacaacaggc ttatttggtg ttaaccctca tatcgggggt ctaactcttt    960

gcttttccag cttttgtgct ggaatatccc attaaactgt ccatgttggg tattttttct   1020

ttgttagtaa acatttgttg catattgttg atagcatttt agatttgaag aaataactga   1080

caaaatcaat atcatctgtt tcatcatt                                      1108


<210>  3242
<211>  67
<212>  PRT
<213>  Homo sapiens

<400>  3242


Met Thr Pro Lys Ser Phe Leu Glu Phe Gly Cys Arg Val Ile Leu Cys 
1               5                   10                  15      


Val Leu Pro Leu Arg Ala Cys His Phe Asp Val Asp Ile Ser Gly Leu 
            20                  25                  30          


Val Leu Val Leu Ser Leu Ser Arg His Val Thr Leu Asp Lys Ser Ser 
        35                  40                  45              


Leu Gln Ala Leu Ile Ser Pro Ser Val Asn Arg Gly Thr Gln Gly Thr 
    50                  55                  60                  


Ser Gly Leu 
65          

<210>  3243
<211>  456
<212>  DNA
<213>  Homo sapiens

<400>  3243
gaccccttgg aagcctctgc ttgtgtccca cgtcctcttg atgccagggc cacttcatct     60

ccaaaacaca aaaccaatgc ctggatgagc ttattagggt gaattaatga gtctgtaatt    120

tgggaacctt aatgtgagac accacttaag gagaggaact tggcccagca agtgatcact    180

ctagaagtgg acagctatgc actagactgc accagaatct gttcaacagc gacaccttgt    240

ggtaaaaact gtagacgccc catcaggctg gatgggaaac tagaaacaga ctgtctcatc    300

tttggacaga tatccctcaa atctcccaat ctactccagg gaaaagacac ttcaagtgag    360

agatattgga cttcttgaaa atctaggcct atggaaaatt aaagtgttaa atggaaaaat    420

taaagagcta tgagtctatt tgtaatgatg aaacag                              456


<210>  3244
<211>  81
<212>  PRT
<213>  Homo sapiens

<400>  3244


Cys Glu Thr Pro Leu Lys Glu Arg Asn Leu Ala Gln Gln Val Ile Thr 
1               5                   10                  15      


Leu Glu Val Asp Ser Tyr Ala Leu Asp Cys Thr Arg Ile Cys Ser Thr 
            20                  25                  30          


Ala Thr Pro Cys Gly Lys Asn Cys Arg Arg Pro Ile Arg Leu Asp Gly 
        35                  40                  45              


Lys Leu Glu Thr Asp Cys Leu Ile Phe Gly Gln Ile Ser Leu Lys Ser 
    50                  55                  60                  


Pro Asn Leu Leu Gln Gly Lys Asp Thr Ser Ser Glu Arg Tyr Trp Thr 
65                  70                  75                  80  


Ser 
    

<210>  3245
<211>  1783
<212>  DNA
<213>  Homo sapiens

<400>  3245
gggcgatcag aagcaggtca cacagcctgt ttcctgtttt caaacgggga acttagaaag     60

tggcagcccc tcggcttgtc gccggagctg agaaccaaga gctcgaaggg gccatatgac    120

actcctcccg gacccctgga cacacacagc cctggagact ggagccttgg agcatggcaa    180

gtccagagca ccctgggagc cctggctgca tgggacccat aacccagtgc acggcaagga    240

cccagcagga agcaccagcc actggccccg acctcccgca cccaggacct gacgggcact    300

tagacacaca cagtggcctg agctccaact ccagcatgac cacgcgggag cttcagcagt    360

actggcagaa ccagaaatgc cgctggaagc acgtcaaact gctctttgag atcgcttcag    420

ctcgcatcga ggagagaaaa gtctctaagt ttgtggtgta ccaaatcatc gtcatccaga    480

ctgggagctt tgacaacaac aaggccgtcc tggaacggcg ctattccgac ttcgcgaagc    540

tccagaaagc gctgctgaag acgttcaggg aggagatcga agacgtggag tttcccagga    600

agcacctgac tgggaacttc gctgaggaga tgatctgtga gcgtcggcgc gccctgcagg    660

agtacctggg cctgctctac gccatccgct gcgtgcgccg ctcccgggag ttcctggact    720

tcctcacgcg gccggagctg cgcgaggctt tcggctgcct gcgggccggc cagtacccgc    780

gcgccctgga gctgctgctg cgcgtgctgc cgctgcagga gaagctcacc gcccactgcc    840

ctgcggccgc cgtcccggcc ctgtgcgccg tgctgctgtg ccaccgcgac ctcgaccgcc    900

ccgccgaggc cttcgcggcc ggagagaggg ccctgcagcg cctgcaggcc cgggagggcc    960

atcgctacta tgcgcctctg ctggacgcca tggtccgcct ggcctacgcg ctgggcaagg   1020

acttcgtgac tctgcaggag aggctggagg agagccagct ccggaggccc acgccccgag   1080

gcatcaccct gaaggagctc actgtgcgag aatacctgca ctgagccggc ctgggacccc   1140

gcagggacgc tggagatttg gggtcaccat ggctcacagt gggctgtttg gggttctttt   1200

tttttatttt tccttttctt ttttgttatt tgagacagtc ttgctctgtc acccagactg   1260

aagtgcagtg gctcaattat gtctcactgc agcctcaaac tcctgggcac aagcaatcct   1320

cccacctcag cctcccaagt agctgggatt acaggtgcac accaccacac caggctaatt   1380

tttaattttt tagtagagac agggtctctc tgttgcccag gctggtctct aacttctgac   1440

cttaaatgat cttcctgcct cagcttccca aaacactggg gttacaagtg tgagccacca   1500

cccctggcct ggggttcatt tttaatggga aaagccactg ggggctctaa ctcgctgggt   1560

gactttggac aagcccctcc tctggtcctc aatttctcca tctgtattgg acagaggtgc   1620

tcctgggacc ccttggaagc ctctgcttgt gtcccacgtc ctcttgatgc cagggccact   1680

tcatctccaa aacacaaaac caactgccaa aaccgtccag agcagtgtcc accccaccag   1740

tgtctttgtg ggaagctgga gaagaagttt acctcacaca ttc                     1783


<210>  3246
<211>  316
<212>  PRT
<213>  Homo sapiens

<400>  3246


Met Ala Ser Pro Glu His Pro Gly Ser Pro Gly Cys Met Gly Pro Ile 
1               5                   10                  15      


Thr Gln Cys Thr Ala Arg Thr Gln Gln Glu Ala Pro Ala Thr Gly Pro 
            20                  25                  30          


Asp Leu Pro His Pro Gly Pro Asp Gly His Leu Asp Thr His Ser Gly 
        35                  40                  45              


Leu Ser Ser Asn Ser Ser Met Thr Thr Arg Glu Leu Gln Gln Tyr Trp 
    50                  55                  60                  


Gln Asn Gln Lys Cys Arg Trp Lys His Val Lys Leu Leu Phe Glu Ile 
65                  70                  75                  80  


Ala Ser Ala Arg Ile Glu Glu Arg Lys Val Ser Lys Phe Val Val Tyr 
                85                  90                  95      


Gln Ile Ile Val Ile Gln Thr Gly Ser Phe Asp Asn Asn Lys Ala Val 
            100                 105                 110         


Leu Glu Arg Arg Tyr Ser Asp Phe Ala Lys Leu Gln Lys Ala Leu Leu 
        115                 120                 125             


Lys Thr Phe Arg Glu Glu Ile Glu Asp Val Glu Phe Pro Arg Lys His 
    130                 135                 140                 


Leu Thr Gly Asn Phe Ala Glu Glu Met Ile Cys Glu Arg Arg Arg Ala 
145                 150                 155                 160 


Leu Gln Glu Tyr Leu Gly Leu Leu Tyr Ala Ile Arg Cys Val Arg Arg 
                165                 170                 175     


Ser Arg Glu Phe Leu Asp Phe Leu Thr Arg Pro Glu Leu Arg Glu Ala 
            180                 185                 190         


Phe Gly Cys Leu Arg Ala Gly Gln Tyr Pro Arg Ala Leu Glu Leu Leu 
        195                 200                 205             


Leu Arg Val Leu Pro Leu Gln Glu Lys Leu Thr Ala His Cys Pro Ala 
    210                 215                 220                 


Ala Ala Val Pro Ala Leu Cys Ala Val Leu Leu Cys His Arg Asp Leu 
225                 230                 235                 240 


Asp Arg Pro Ala Glu Ala Phe Ala Ala Gly Glu Arg Ala Leu Gln Arg 
                245                 250                 255     


Leu Gln Ala Arg Glu Gly His Arg Tyr Tyr Ala Pro Leu Leu Asp Ala 
            260                 265                 270         


Met Val Arg Leu Ala Tyr Ala Leu Gly Lys Asp Phe Val Thr Leu Gln 
        275                 280                 285             


Glu Arg Leu Glu Glu Ser Gln Leu Arg Arg Pro Thr Pro Arg Gly Ile 
    290                 295                 300                 


Thr Leu Lys Glu Leu Thr Val Arg Glu Tyr Leu His 
305                 310                 315     

<210>  3247
<211>  496
<212>  DNA
<213>  Homo sapiens

<400>  3247
ggagtgggcc ttggagtcgg cgcgcaggcg gctcgcggtt gtgaaatgtg ctcgcaggag     60

gcttttcagg cacagaggag ccagctggtc gagctgctgg tctcagggtc cctggaaggc    120

ttcgagagtg tcctggactg gctgctgtcc tgggaggtcc tctcctggga ggactacgag    180

ggcttccacc tcctgggcca gcctctctcc cacttggcca ggcgccttct ggacaccgtc    240

tggaataagg gtacttgggc ctgtcagaag ctcatcgcgg ctgcccaaga agcccaggcc    300

gacagccagt cccccaagct gcatggctgc tgggaccccc actcgctcca cccagcccga    360

gacctgcaga gtcaccggcc agccattgtc aggaggctcc acagccatgt ggagaacatg    420

ctggacctgg catgggagcg gggtttcgtc agccagtatg aatgtgatga aatcaggttg    480

ccgatcttca caccgt                                                    496


<210>  3248
<211>  149
<212>  PRT
<213>  Homo sapiens

<400>  3248


Met Cys Ser Gln Glu Ala Phe Gln Ala Gln Arg Ser Gln Leu Val Glu 
1               5                   10                  15      


Leu Leu Val Ser Gly Ser Leu Glu Gly Phe Glu Ser Val Leu Asp Trp 
            20                  25                  30          


Leu Leu Ser Trp Glu Val Leu Ser Trp Glu Asp Tyr Glu Gly Phe His 
        35                  40                  45              


Leu Leu Gly Gln Pro Leu Ser His Leu Ala Arg Arg Leu Leu Asp Thr 
    50                  55                  60                  


Val Trp Asn Lys Gly Thr Trp Ala Cys Gln Lys Leu Ile Ala Ala Ala 
65                  70                  75                  80  


Gln Glu Ala Gln Ala Asp Ser Gln Ser Pro Lys Leu His Gly Cys Trp 
                85                  90                  95      


Asp Pro His Ser Leu His Pro Ala Arg Asp Leu Gln Ser His Arg Pro 
            100                 105                 110         


Ala Ile Val Arg Arg Leu His Ser His Val Glu Asn Met Leu Asp Leu 
        115                 120                 125             


Ala Trp Glu Arg Gly Phe Val Ser Gln Tyr Glu Cys Asp Glu Ile Arg 
    130                 135                 140                 


Leu Pro Ile Phe Thr 
145                 

<210>  3249
<211>  637
<212>  DNA
<213>  Homo sapiens

<400>  3249
ggagtgggcc ttggagtcgg cgcgcaggcg gctcgcgcaa ggaagtgatc ctttctctac     60

atgggcctca ccttggggag gacaatggtg tctttgaagt tgtagtaact gaagtagaga    120

tcaaaaggca atgcagatag actgacagat ttcgcctgaa gaggggaagc ccgaccaggt    180

tgtgaaatgt gctcgcagga ggcttttcag gcacagagga gccagctggt cgagctgctg    240

gtctcagggt ccctggaagg cttcgagagt gtcctggact ggctgctgtc ctgggaggtc    300

ctctcctggg aggactacga gggcttccac ctcctgggcc agcctctctc ccacttggcc    360

aggcgccttc tggacaccgt ctggaataag ggtacttggg cctgtcagaa gctcatcgcg    420

gctgcccaag aagcccaggc cgacagccag tcccccaagc tgcatggctg ctgggacccc    480

cactcgctcc acccagcccg agacctgcag agtcaccggc cagccattgt caggaggctc    540

cacagccatg tggagaacat gctggacctg gcatgggagc ggggtttcgt cagccagtat    600

gaatgtgatg aaatcaggtt gccgatcttc acaccgt                             637


<210>  3250
<211>  149
<212>  PRT
<213>  Homo sapiens

<400>  3250


Met Cys Ser Gln Glu Ala Phe Gln Ala Gln Arg Ser Gln Leu Val Glu 
1               5                   10                  15      


Leu Leu Val Ser Gly Ser Leu Glu Gly Phe Glu Ser Val Leu Asp Trp 
            20                  25                  30          


Leu Leu Ser Trp Glu Val Leu Ser Trp Glu Asp Tyr Glu Gly Phe His 
        35                  40                  45              


Leu Leu Gly Gln Pro Leu Ser His Leu Ala Arg Arg Leu Leu Asp Thr 
    50                  55                  60                  


Val Trp Asn Lys Gly Thr Trp Ala Cys Gln Lys Leu Ile Ala Ala Ala 
65                  70                  75                  80  


Gln Glu Ala Gln Ala Asp Ser Gln Ser Pro Lys Leu His Gly Cys Trp 
                85                  90                  95      


Asp Pro His Ser Leu His Pro Ala Arg Asp Leu Gln Ser His Arg Pro 
            100                 105                 110         


Ala Ile Val Arg Arg Leu His Ser His Val Glu Asn Met Leu Asp Leu 
        115                 120                 125             


Ala Trp Glu Arg Gly Phe Val Ser Gln Tyr Glu Cys Asp Glu Ile Arg 
    130                 135                 140                 


Leu Pro Ile Phe Thr 
145                 

<210>  3251
<211>  4484
<212>  DNA
<213>  Homo sapiens

<400>  3251
gtagacagat ccaggctcac cagtcctgtg ccactgggct tttggcgttc tgcacaaggc     60

ctacccgcag atgccatgcc tgctccccca gcctaatggg ctttgatggg ggaagagggt    120

ggttcagcct ctcacgatga ggaggaaaga gcaagtgtcc tcctcggaca ttctccgggt    180

tgtgaaatgt gctcgcagga ggcttttcag gcacagagga gccagctggt cgagctgctg    240

gtctcagggt ccctggaagg cttcgagagt gtcctggact ggctgctgtc ctgggaggtc    300

ctctcctggg aggactacga gggcttccac ctcctgggcc agcctctctc ccacttggcc    360

aggcgccttc tggacaccgt ctggaataag ggtacttggg cctgtcagaa gctcatcgcg    420

gctgcccaag aagcccaggc cgacagccag tcccccaagc tgcatggctg ctgggacccc    480

cactcgctcc acccagcccg agacctgcag agtcaccggc cagccattgt caggaggctc    540

cacagccatg tggagaacat gctggacctg gcatgggagc ggggtttcgt cagccagtat    600

gaatgtgatg aaatcaggtt gccgatcttc acaccgtccc agagggcaag aaggctgctt    660

gatcttgcca cggtgaaagc gaatggattg gctgccttcc ttctacaaca tgttcaggaa    720

ttaccagtcc cattggccct gcctttggaa gctgccacat gcaagaagta tatggccaag    780

ctgaggacca cggtgtctgc tcagtctcgc ttcctcagta cctatgatgg agcagagacg    840

ctctgcctgg aggacatata cacagagaat gtcctggagg tctgggcaga tgtgggcatg    900

gctggacccc cgcagaagag cccagccacc ctgggcctgg aggagctctt cagcacccct    960

ggccacctca atgacgatgc ggacactgtg ctggtggtgg gtgaggcggg cagtggcaag   1020

agcacgctcc tgcagcggct gcacttgctg tgggctgcag ggcaagactt ccaggaattt   1080

ctctttgtct tcccattcag ctgccggcag ctgcagtgca tggccaaacc actctctgtg   1140

cggactctac tctttgagca ctgctgttgg cctgatgttg gtcaagaaga catcttccag   1200

ttactccttg accaccctga ccgtgtcctg ttaacctttg atggctttga cgagttcaag   1260

ttcaggttca cggatcgtga acgccactgc tccccgaccg accccacctc tgtccagacc   1320

ctgctcttca accttctgca gggcaacctg ctgaagaatg cccgcaaggt ggtgaccagc   1380

cgtccggccg ctgtgtcggc gttcctcagg aagtacatcc gcaccgagtt caacctcaag   1440

ggcttctctg aacagggcat cgagctgtac ctgaggaagc gccatcatga gcccggggtg   1500

gcggaccgcc tcatccgcct gctccaagag acctcagccc tgcacggttt gtgccacctg   1560

cctgtcttct catggatggt gtccaaatgc caccaggaac tgttgctgca ggaggggggg   1620

tccccaaaga ccactacaga tatgtacctg ctgattctgc agcattttct gctgcatgcc   1680

acccccccag actcagcttc ccaaggtctg ggacccagtc ttcttcgggg ccgcctcccc   1740

accctcctgc acctgggcag actggctctg tggggcctgg gcatgtgctg ctacgtgttc   1800

tcagcccagc agctccaggc agcacaggtc agccctgatg acatttctct tggcttcctg   1860

gtgcgtgcca aaggtgtcgt gccagggagt acggcgcccc tggaattcct tcacatcact   1920

ttccagtgct tctttgccgc gttctacctg gcactcagtg ctgatgtgcc accagctttg   1980

ctcagacacc tcttcaattg tggcaggcca ggcaactcac caatggccag gctcctgccc   2040

acgatgtgca tccaggcctc ggagggaaag gacagcagcg tggcagcttt gctgcagaag   2100

gccgagccgc acaaccttca gatcacagca gccttcctgg cagggctgtt gtcccgggag   2160

cactggggcc tgctggctga gtgccagaca tctgagaagg ccctgctccg gcgccaggcc   2220

tgtgcccgct ggtgtctggc ccgcagcctc cgcaagcact tccactccat cccgccagct   2280

gcaccgggtg aggccaagag cgtgcatgcc atgcccgggt tcatctggct catccggagc   2340

ctgtacgaga tgcaggagga gcggctggct cggaaggctg cacgtggcct gaatgttggg   2400

cacctcaagt tgacattttg cagtgtgggc cccactgagt gtgctgccct ggcctttgtg   2460

ctgcagcacc tccggcggcc cgtggccctg cagctggact acaactctgt gggtgacatt   2520

ggcgtggagc agctgctgcc ttgccttggt gtctgcaagg ctctgtattt gcgcgataac   2580

aatatctcag accgaggcat ctgcaagctc attgaatgtg ctcttcactg cgagcaattg   2640

cagaagttag ctctattcaa caacaaattg actgacggct gtgcacactc catggctaag   2700

ctccttgcat gcaggcagaa cttcttggca ttgaggctgg ggaataacta catcactgcc   2760

gcgggagccc aagtgctggc cgaggggctc cgaggcaaca cctccttgca gttcctggga   2820

ttctggggca acagagtggg tgacgagggg gcccaggccc tggctgaagc cttgggtgat   2880

caccagagct tgaggtggct cagcctggtg gggaacaaca ttggcagtgt gggtgcccaa   2940

gccttggcac tgatgctggc aaagaacgtc atgctagaag aactctgcct ggaggagaac   3000

catctccagg atgaaggtgt atgttctctc gcagaaggac tgaagaaaaa ttcaagtttg   3060

aaaatcctga agttgtccaa taactgcatc acctacctag gggcagaagc cctcctgcag   3120

gcccttgaaa ggaatgacac catcctggaa gtctggctcc gagggaacac tttctctcta   3180

gaggaggttg acaagctcgg ctgcagggac accagactct tgctttgaag tctccgggag   3240

gatgttcgtc tcagtttgtt tgtgagcagg ctgtgagttt gggccccaga ggctgggtga   3300

catgtgttgg cagcctcttc aaaatgagcc ctgtcctgcc taaggctgaa cttgttttct   3360

gggaacacca taggtcacct ttattctggc agaggaggga gcatcagtgc cctccaggat   3420

agacttttcc caagcctact tttgccattg acttcttccc aagattcaat cccaggatgt   3480

acaaggacag cccctcctcc atagtatggg actggcctct gctgatcctc ccaggcttcc   3540

gtgtgggtca gtggggccca tggatgtgct tgttaactga gtgccttttg gtggagaggc   3600

ccggcctctc acaaaagacc ccttaccact gctctgatga agaggagtac acagaacaca   3660

taattcagga agcagctttc cccatgtctc gactcatcca tccaggccat tccccgtctc   3720

tggttcctcc cctcctcctg gactcctgca cacgctcctt cctctgaggc tgaaattcag   3780

aatattagtg acctcagctt tgatatttca cttacagcac ccccaaccct ggcacccagg   3840

gtgggaaggg ctacacctta gcctgccctc ctttccggtg tttaagacat ttttggaagg   3900

ggacacgtga cagccgtttg ttccccaaga cattctaggt ttgcaagaaa aatatgacca   3960

cactccagct gggatcacat gtggactttt atttccagtg aaatcagtta ctcttcagtt   4020

aagcctttgg aaacagctcg actttaaaaa gctccaaatg cagctttaaa aaattaatct   4080

gggccagaat ttcaaacggc ctcactaggc ttctggttga tgcctgtgaa ctgaactctg   4140

acaacagact tctgaaatag acccacaaga ggcagttcca tttcatttgt gccagaatgc   4200

tttaggatgt acagttatgg attgaaagtt tacaggaaaa aaaattaggc cgttccttca   4260

aagcaaatgt cttcctggat tattcaaaat gatgtatgtt gaagcctttg taaattgtca   4320

gatgctgtgc aaatgttatt attttaaaca ttatgatgtg tgaaaactgg ttaatattta   4380

taggtcactt tgttttactg tcttaagttt atactcttat agacaacatg gccgtgaact   4440

ttatgctgta aataatcaga ggggaataaa ctgttgagtc aaaa                    4484


<210>  3252
<211>  1040
<212>  PRT
<213>  Homo sapiens

<400>  3252


Met Gly Glu Glu Gly Gly Ser Ala Ser His Asp Glu Glu Glu Arg Ala 
1               5                   10                  15      


Ser Val Leu Leu Gly His Ser Pro Gly Cys Glu Met Cys Ser Gln Glu 
            20                  25                  30          


Ala Phe Gln Ala Gln Arg Ser Gln Leu Val Glu Leu Leu Val Ser Gly 
        35                  40                  45              


Ser Leu Glu Gly Phe Glu Ser Val Leu Asp Trp Leu Leu Ser Trp Glu 
    50                  55                  60                  


Val Leu Ser Trp Glu Asp Tyr Glu Gly Phe His Leu Leu Gly Gln Pro 
65                  70                  75                  80  


Leu Ser His Leu Ala Arg Arg Leu Leu Asp Thr Val Trp Asn Lys Gly 
                85                  90                  95      


Thr Trp Ala Cys Gln Lys Leu Ile Ala Ala Ala Gln Glu Ala Gln Ala 
            100                 105                 110         


Asp Ser Gln Ser Pro Lys Leu His Gly Cys Trp Asp Pro His Ser Leu 
        115                 120                 125             


His Pro Ala Arg Asp Leu Gln Ser His Arg Pro Ala Ile Val Arg Arg 
    130                 135                 140                 


Leu His Ser His Val Glu Asn Met Leu Asp Leu Ala Trp Glu Arg Gly 
145                 150                 155                 160 


Phe Val Ser Gln Tyr Glu Cys Asp Glu Ile Arg Leu Pro Ile Phe Thr 
                165                 170                 175     


Pro Ser Gln Arg Ala Arg Arg Leu Leu Asp Leu Ala Thr Val Lys Ala 
            180                 185                 190         


Asn Gly Leu Ala Ala Phe Leu Leu Gln His Val Gln Glu Leu Pro Val 
        195                 200                 205             


Pro Leu Ala Leu Pro Leu Glu Ala Ala Thr Cys Lys Lys Tyr Met Ala 
    210                 215                 220                 


Lys Leu Arg Thr Thr Val Ser Ala Gln Ser Arg Phe Leu Ser Thr Tyr 
225                 230                 235                 240 


Asp Gly Ala Glu Thr Leu Cys Leu Glu Asp Ile Tyr Thr Glu Asn Val 
                245                 250                 255     


Leu Glu Val Trp Ala Asp Val Gly Met Ala Gly Pro Pro Gln Lys Ser 
            260                 265                 270         


Pro Ala Thr Leu Gly Leu Glu Glu Leu Phe Ser Thr Pro Gly His Leu 
        275                 280                 285             


Asn Asp Asp Ala Asp Thr Val Leu Val Val Gly Glu Ala Gly Ser Gly 
    290                 295                 300                 


Lys Ser Thr Leu Leu Gln Arg Leu His Leu Leu Trp Ala Ala Gly Gln 
305                 310                 315                 320 


Asp Phe Gln Glu Phe Leu Phe Val Phe Pro Phe Ser Cys Arg Gln Leu 
                325                 330                 335     


Gln Cys Met Ala Lys Pro Leu Ser Val Arg Thr Leu Leu Phe Glu His 
            340                 345                 350         


Cys Cys Trp Pro Asp Val Gly Gln Glu Asp Ile Phe Gln Leu Leu Leu 
        355                 360                 365             


Asp His Pro Asp Arg Val Leu Leu Thr Phe Asp Gly Phe Asp Glu Phe 
    370                 375                 380                 


Lys Phe Arg Phe Thr Asp Arg Glu Arg His Cys Ser Pro Thr Asp Pro 
385                 390                 395                 400 


Thr Ser Val Gln Thr Leu Leu Phe Asn Leu Leu Gln Gly Asn Leu Leu 
                405                 410                 415     


Lys Asn Ala Arg Lys Val Val Thr Ser Arg Pro Ala Ala Val Ser Ala 
            420                 425                 430         


Phe Leu Arg Lys Tyr Ile Arg Thr Glu Phe Asn Leu Lys Gly Phe Ser 
        435                 440                 445             


Glu Gln Gly Ile Glu Leu Tyr Leu Arg Lys Arg His His Glu Pro Gly 
    450                 455                 460                 


Val Ala Asp Arg Leu Ile Arg Leu Leu Gln Glu Thr Ser Ala Leu His 
465                 470                 475                 480 


Gly Leu Cys His Leu Pro Val Phe Ser Trp Met Val Ser Lys Cys His 
                485                 490                 495     


Gln Glu Leu Leu Leu Gln Glu Gly Gly Ser Pro Lys Thr Thr Thr Asp 
            500                 505                 510         


Met Tyr Leu Leu Ile Leu Gln His Phe Leu Leu His Ala Thr Pro Pro 
        515                 520                 525             


Asp Ser Ala Ser Gln Gly Leu Gly Pro Ser Leu Leu Arg Gly Arg Leu 
    530                 535                 540                 


Pro Thr Leu Leu His Leu Gly Arg Leu Ala Leu Trp Gly Leu Gly Met 
545                 550                 555                 560 


Cys Cys Tyr Val Phe Ser Ala Gln Gln Leu Gln Ala Ala Gln Val Ser 
                565                 570                 575     


Pro Asp Asp Ile Ser Leu Gly Phe Leu Val Arg Ala Lys Gly Val Val 
            580                 585                 590         


Pro Gly Ser Thr Ala Pro Leu Glu Phe Leu His Ile Thr Phe Gln Cys 
        595                 600                 605             


Phe Phe Ala Ala Phe Tyr Leu Ala Leu Ser Ala Asp Val Pro Pro Ala 
    610                 615                 620                 


Leu Leu Arg His Leu Phe Asn Cys Gly Arg Pro Gly Asn Ser Pro Met 
625                 630                 635                 640 


Ala Arg Leu Leu Pro Thr Met Cys Ile Gln Ala Ser Glu Gly Lys Asp 
                645                 650                 655     


Ser Ser Val Ala Ala Leu Leu Gln Lys Ala Glu Pro His Asn Leu Gln 
            660                 665                 670         


Ile Thr Ala Ala Phe Leu Ala Gly Leu Leu Ser Arg Glu His Trp Gly 
        675                 680                 685             


Leu Leu Ala Glu Cys Gln Thr Ser Glu Lys Ala Leu Leu Arg Arg Gln 
    690                 695                 700                 


Ala Cys Ala Arg Trp Cys Leu Ala Arg Ser Leu Arg Lys His Phe His 
705                 710                 715                 720 


Ser Ile Pro Pro Ala Ala Pro Gly Glu Ala Lys Ser Val His Ala Met 
                725                 730                 735     


Pro Gly Phe Ile Trp Leu Ile Arg Ser Leu Tyr Glu Met Gln Glu Glu 
            740                 745                 750         


Arg Leu Ala Arg Lys Ala Ala Arg Gly Leu Asn Val Gly His Leu Lys 
        755                 760                 765             


Leu Thr Phe Cys Ser Val Gly Pro Thr Glu Cys Ala Ala Leu Ala Phe 
    770                 775                 780                 


Val Leu Gln His Leu Arg Arg Pro Val Ala Leu Gln Leu Asp Tyr Asn 
785                 790                 795                 800 


Ser Val Gly Asp Ile Gly Val Glu Gln Leu Leu Pro Cys Leu Gly Val 
                805                 810                 815     


Cys Lys Ala Leu Tyr Leu Arg Asp Asn Asn Ile Ser Asp Arg Gly Ile 
            820                 825                 830         


Cys Lys Leu Ile Glu Cys Ala Leu His Cys Glu Gln Leu Gln Lys Leu 
        835                 840                 845             


Ala Leu Phe Asn Asn Lys Leu Thr Asp Gly Cys Ala His Ser Met Ala 
    850                 855                 860                 


Lys Leu Leu Ala Cys Arg Gln Asn Phe Leu Ala Leu Arg Leu Gly Asn 
865                 870                 875                 880 


Asn Tyr Ile Thr Ala Ala Gly Ala Gln Val Leu Ala Glu Gly Leu Arg 
                885                 890                 895     


Gly Asn Thr Ser Leu Gln Phe Leu Gly Phe Trp Gly Asn Arg Val Gly 
            900                 905                 910         


Asp Glu Gly Ala Gln Ala Leu Ala Glu Ala Leu Gly Asp His Gln Ser 
        915                 920                 925             


Leu Arg Trp Leu Ser Leu Val Gly Asn Asn Ile Gly Ser Val Gly Ala 
    930                 935                 940                 


Gln Ala Leu Ala Leu Met Leu Ala Lys Asn Val Met Leu Glu Glu Leu 
945                 950                 955                 960 


Cys Leu Glu Glu Asn His Leu Gln Asp Glu Gly Val Cys Ser Leu Ala 
                965                 970                 975     


Glu Gly Leu Lys Lys Asn Ser Ser Leu Lys Ile Leu Lys Leu Ser Asn 
            980                 985                 990         


Asn Cys Ile Thr Tyr Leu Gly Ala  Glu Ala Leu Leu Gln  Ala Leu Glu 
        995                 1000                 1005             


Arg Asn  Asp Thr Ile Leu Glu  Val Trp Leu Arg Gly  Asn Thr Phe 
    1010                 1015                 1020             


Ser Leu  Glu Glu Val Asp Lys  Leu Gly Cys Arg Asp  Thr Arg Leu 
    1025                 1030                 1035             


Leu Leu  
    1040 

<210>  3253
<211>  878
<212>  DNA
<213>  Homo sapiens

<400>  3253
tagacagatc caggctcacc agtcctgtgc cactgggctt ttggcgttct gcacaaggcc     60

tacccgcaga tgccatgcct gctcccccag cctaatgggc tttgatgggg gaagagggtg    120

gttcagcctc tcacgatgag gaggaaagag caagtgtcct cctcggacat tctccgggtt    180

gtgaaatgtg ctcgcaggag gcttttcagg cacagaggag ccagctggtc gagctgctgg    240

tctcagggtc cctggaaggc ttcgagagtg tcctggactg gctgctgtcc tgggaggtcc    300

tctcctggga ggactacgag ggcttccacc tcctgggcca gcctctctcc cacttggcca    360

ggcgccttct ggacaccgtc tggaataagg gtacttgggc ctgtcagaag ctcatcgcgg    420

ctgcccaaga agcccaggcc gacagccagt cccccaagct gcatggctgc tgggaccccc    480

actcgctcca cccagcccga gacctgcaga gtcaccggcc agccattgtc aggaggctcc    540

acagccatgt ggagaacatg ctggacctgg catgggagcg gggtttcgtc agccagtatg    600

aatgtgatga aatcaggttg ccgatcttca caccgtccca gaggctgcca catgcaagaa    660

gtatatggcc aagctgagga ccacggtgtc tgctcagtct cgcttcctca gtacctatga    720

tggagcagag acgctctgcc tggaggacat atacacagag aatgtcctgg aggtctgggc    780

agatgtgggc atggctggac ccccgcagaa gagcccagcc accctgggcc tggaggagct    840

cttcagcacc cctggccacc tcaatgacga tgcggaca                            878


<210>  3254
<211>  194
<212>  PRT
<213>  Homo sapiens

<400>  3254


Met Arg Arg Lys Glu Gln Val Ser Ser Ser Asp Ile Leu Arg Val Val 
1               5                   10                  15      


Lys Cys Ala Arg Arg Arg Leu Phe Arg His Arg Gly Ala Ser Trp Ser 
            20                  25                  30          


Ser Cys Trp Ser Gln Gly Pro Trp Lys Ala Ser Arg Val Ser Trp Thr 
        35                  40                  45              


Gly Cys Cys Pro Gly Arg Ser Ser Pro Gly Arg Thr Thr Arg Ala Ser 
    50                  55                  60                  


Thr Ser Trp Ala Ser Leu Ser Pro Thr Trp Pro Gly Ala Phe Trp Thr 
65                  70                  75                  80  


Pro Ser Gly Ile Arg Val Leu Gly Pro Val Arg Ser Ser Ser Arg Leu 
                85                  90                  95      


Pro Lys Lys Pro Arg Pro Thr Ala Ser Pro Pro Ser Cys Met Ala Ala 
            100                 105                 110         


Gly Thr Pro Thr Arg Ser Thr Gln Pro Glu Thr Cys Arg Val Thr Gly 
        115                 120                 125             


Gln Pro Leu Ser Gly Gly Ser Thr Ala Met Trp Arg Thr Cys Trp Thr 
    130                 135                 140                 


Trp His Gly Ser Gly Val Ser Ser Ala Ser Met Asn Val Met Lys Ser 
145                 150                 155                 160 


Gly Cys Arg Ser Ser His Arg Pro Arg Gly Cys His Met Gln Glu Val 
                165                 170                 175     


Tyr Gly Gln Ala Glu Asp His Gly Val Cys Ser Val Ser Leu Pro Gln 
            180                 185                 190         


Tyr Leu 
        

<210>  3255
<211>  1707
<212>  DNA
<213>  Homo sapiens

<400>  3255
tagacagatc caggctcacc agtcctgtgc cactgggctt ttggcgttct gcacaaggcc     60

tacccgcaga tgccatgcct gctcccccag cctaatgggc tttgatgggg gaagagggtg    120

gttcagcctc tcacgatgag gaggaaagag caagtgtcct cctcggacat tctccgggta    180

agaggagcag gcattgtccc gtcccagctt gatcctcagc cttctttcat ccttggccgc    240

gacatgctcc caggcctggg gtcagatggg gagtgctgac tctgtttctg ggctgttttc    300

tggggagaat gggtcggcgg gtttttttcc ccaggacctg ggcagggtca atggtggggg    360

ccgctgtcgc atccttggct ggtgtttcca cagctgagaa ccactccagg gccaagccca    420

gagcttattc tacccttttt tgtcctctct tcccctgtcc tcggccaccc caccctcttg    480

gctcctctgc ttagatgtgg gcacaaggag gagaactcct tggcctgaga gaactacctt    540

agatcctggc ttccagtggc ctctgcaggg gggtacaccc tctctcccaa gcagccagac    600

acacaagtaa cctcattgcc tcagtttccc catctgacca gcacagggcc ccctgtgccc    660

cagcagcgtt ctgagagatt ggagctttct ccttttgctt accttggcta ccgtatgagg    720

acggatacag agtgttcccc ccacccccag cccaggggat atttgattca tgaacattcc    780

ctcagtgtct ttgtggggga caatgctgtg ccaggctcag ggatgccagg acgagtaaga    840

cccaggctcc cacgtggccc aggcagggag agagacacat aaacaaccat caggaaagag    900

gttgtgaaat gtgctcgcag gaggcttttc aggcacagag gagccagctg gtcgagctgc    960

tggtctcagg gtccctggaa ggcttcgaga gtgtcctgga ctggctgctg tcctgggagg   1020

tcctctcctg ggaggactac gagggcttcc acctcctggg ccagcctctc tcccacttgg   1080

ccaggcgcct tctggacacc gtctggaata agggtacttg ggcctgtcag aagctcatcg   1140

cggctgccca agaagcccag gccgacagcc agtcccccaa gctgcatggc tgctgggacc   1200

cccactcgct ccacccagcc cgagacctgc agagtcaccg gccagccatt gtcaggaggc   1260

tccacagcca tgtggagaac atgctggacc tggcatggga gcggggtttc gtcagccagt   1320

atgaatgtga tgaaatcagg ttgccgatct tcacaccgtc ccagagggca agaaggctgc   1380

ttgatcttgc cacggtgaaa gcgaatggat tggctgcctt ccttctacaa catgttcagg   1440

aattaccagt cccattggcc ctgcctttgg aagctgccac atgcaagaag tatatggcca   1500

agctgaggac cacggtgtct gctcagtctc gcttcctcag tacctatgat ggagcagaga   1560

cgctctgcct ggaggacata tacacagaga atgtcctgga ggtctgggca gatgtgggca   1620

tggctggacc cccgcagaag agcccagcca ccctgggcct ggaggagctc ttcagcaccc   1680

ctggccacct caatgacgat gcggaca                                       1707


<210>  3256
<211>  265
<212>  PRT
<213>  Homo sapiens

<400>  3256


Met Cys Ser Gln Glu Ala Phe Gln Ala Gln Arg Ser Gln Leu Val Glu 
1               5                   10                  15      


Leu Leu Val Ser Gly Ser Leu Glu Gly Phe Glu Ser Val Leu Asp Trp 
            20                  25                  30          


Leu Leu Ser Trp Glu Val Leu Ser Trp Glu Asp Tyr Glu Gly Phe His 
        35                  40                  45              


Leu Leu Gly Gln Pro Leu Ser His Leu Ala Arg Arg Leu Leu Asp Thr 
    50                  55                  60                  


Val Trp Asn Lys Gly Thr Trp Ala Cys Gln Lys Leu Ile Ala Ala Ala 
65                  70                  75                  80  


Gln Glu Ala Gln Ala Asp Ser Gln Ser Pro Lys Leu His Gly Cys Trp 
                85                  90                  95      


Asp Pro His Ser Leu His Pro Ala Arg Asp Leu Gln Ser His Arg Pro 
            100                 105                 110         


Ala Ile Val Arg Arg Leu His Ser His Val Glu Asn Met Leu Asp Leu 
        115                 120                 125             


Ala Trp Glu Arg Gly Phe Val Ser Gln Tyr Glu Cys Asp Glu Ile Arg 
    130                 135                 140                 


Leu Pro Ile Phe Thr Pro Ser Gln Arg Ala Arg Arg Leu Leu Asp Leu 
145                 150                 155                 160 


Ala Thr Val Lys Ala Asn Gly Leu Ala Ala Phe Leu Leu Gln His Val 
                165                 170                 175     


Gln Glu Leu Pro Val Pro Leu Ala Leu Pro Leu Glu Ala Ala Thr Cys 
            180                 185                 190         


Lys Lys Tyr Met Ala Lys Leu Arg Thr Thr Val Ser Ala Gln Ser Arg 
        195                 200                 205             


Phe Leu Ser Thr Tyr Asp Gly Ala Glu Thr Leu Cys Leu Glu Asp Ile 
    210                 215                 220                 


Tyr Thr Glu Asn Val Leu Glu Val Trp Ala Asp Val Gly Met Ala Gly 
225                 230                 235                 240 


Pro Pro Gln Lys Ser Pro Ala Thr Leu Gly Leu Glu Glu Leu Phe Ser 
                245                 250                 255     


Thr Pro Gly His Leu Asn Asp Asp Ala 
            260                 265 

<210>  3257
<211>  1115
<212>  DNA
<213>  Homo sapiens

<400>  3257
gggcatgtgc tgctacgtgt tctcagccca gcagctccag gcagcacagg tcagccctga     60

tgacatttct cttggcttcc tggtgcgtgc caaaggtgtc gtgccaggga gtacggcgcc    120

cctggaattc cttcacatca ctttccagtg cttctttgcc gcgttctacc tggcactcag    180

tgctgatgtg ccaccagctt tgctcagaca cctcttcaat tgtggcaggc caggcaactc    240

accaatggcc aggctcctgc ccacgatgtg catccaggcc tcggagggaa aggacagcag    300

cgtggcagct ttgctgcaga aggccgagcc gcacaacctt cagatcacag cagccttcct    360

ggcagggctg ttgtcccggg agcactgggg cctgctggct gagtgccaga catctgagaa    420

ggccctgctc cggcgccagg cctgtgcccg ctggtgtctg gcccgcagcc tccgcaagca    480

cttccactcc atcccgccag ctgcaccggg tgaggccaag agcgtgcatg ccatgcccgg    540

gttcatctgg ctcatccgga gcctgtacga gatgcaggag gagcggctgg ctcggaaggc    600

tgcacgtggc ctgaatgttg ggcacctcaa gttgacattt tgcagtgtgg gccccactga    660

gtgtgctgcc ctggcctttg tgctgcagca cctccggcgg cccgtggccc tgcagctgga    720

ctacaactct gtgggtgaca ttggcgtgga gcagctgctg ccttgccttg gtgtctgcaa    780

ggctctgtat ttgcgcgata acaatatctc agaccgaggc atctgcaagc tcattgaatg    840

tgctcttcac tgcgagcaat tgcagaagtt agcgctgggg aataactaca tcactgccgc    900

gggagcccaa gtgctggccg aggggctccg aggcaacacc tccttgcagt tcctgggatt    960

ctggggcaac agagtgggtg acgagggggc ccaggccctg gctgaagcct tgggtgatca   1020

ccagagcttg aggtggctca gcctggtggg gaacaacatt ggcagtgtgg gtgcccaagc   1080

cttggcactg atgctggcaa agaacgtcat gctag                              1115


<210>  3258
<211>  369
<212>  PRT
<213>  Homo sapiens

<400>  3258


Met Cys Cys Tyr Val Phe Ser Ala Gln Gln Leu Gln Ala Ala Gln Val 
1               5                   10                  15      


Ser Pro Asp Asp Ile Ser Leu Gly Phe Leu Val Arg Ala Lys Gly Val 
            20                  25                  30          


Val Pro Gly Ser Thr Ala Pro Leu Glu Phe Leu His Ile Thr Phe Gln 
        35                  40                  45              


Cys Phe Phe Ala Ala Phe Tyr Leu Ala Leu Ser Ala Asp Val Pro Pro 
    50                  55                  60                  


Ala Leu Leu Arg His Leu Phe Asn Cys Gly Arg Pro Gly Asn Ser Pro 
65                  70                  75                  80  


Met Ala Arg Leu Leu Pro Thr Met Cys Ile Gln Ala Ser Glu Gly Lys 
                85                  90                  95      


Asp Ser Ser Val Ala Ala Leu Leu Gln Lys Ala Glu Pro His Asn Leu 
            100                 105                 110         


Gln Ile Thr Ala Ala Phe Leu Ala Gly Leu Leu Ser Arg Glu His Trp 
        115                 120                 125             


Gly Leu Leu Ala Glu Cys Gln Thr Ser Glu Lys Ala Leu Leu Arg Arg 
    130                 135                 140                 


Gln Ala Cys Ala Arg Trp Cys Leu Ala Arg Ser Leu Arg Lys His Phe 
145                 150                 155                 160 


His Ser Ile Pro Pro Ala Ala Pro Gly Glu Ala Lys Ser Val His Ala 
                165                 170                 175     


Met Pro Gly Phe Ile Trp Leu Ile Arg Ser Leu Tyr Glu Met Gln Glu 
            180                 185                 190         


Glu Arg Leu Ala Arg Lys Ala Ala Arg Gly Leu Asn Val Gly His Leu 
        195                 200                 205             


Lys Leu Thr Phe Cys Ser Val Gly Pro Thr Glu Cys Ala Ala Leu Ala 
    210                 215                 220                 


Phe Val Leu Gln His Leu Arg Arg Pro Val Ala Leu Gln Leu Asp Tyr 
225                 230                 235                 240 


Asn Ser Val Gly Asp Ile Gly Val Glu Gln Leu Leu Pro Cys Leu Gly 
                245                 250                 255     


Val Cys Lys Ala Leu Tyr Leu Arg Asp Asn Asn Ile Ser Asp Arg Gly 
            260                 265                 270         


Ile Cys Lys Leu Ile Glu Cys Ala Leu His Cys Glu Gln Leu Gln Lys 
        275                 280                 285             


Leu Ala Leu Gly Asn Asn Tyr Ile Thr Ala Ala Gly Ala Gln Val Leu 
    290                 295                 300                 


Ala Glu Gly Leu Arg Gly Asn Thr Ser Leu Gln Phe Leu Gly Phe Trp 
305                 310                 315                 320 


Gly Asn Arg Val Gly Asp Glu Gly Ala Gln Ala Leu Ala Glu Ala Leu 
                325                 330                 335     


Gly Asp His Gln Ser Leu Arg Trp Leu Ser Leu Val Gly Asn Asn Ile 
            340                 345                 350         


Gly Ser Val Gly Ala Gln Ala Leu Ala Leu Met Leu Ala Lys Asn Val 
        355                 360                 365             


Met 
    

<210>  3259
<211>  1211
<212>  DNA
<213>  Homo sapiens

<400>  3259
gggcatgtgc tgctacgtgt tctcagccca gcagctccag gcagcacagg tcagccctga     60

tgacatttct cttggcttcc tggtgcgtgc caaaggtgtc gtgccaggga gtacggcgcc    120

cctggaattc cttcacatca ctttccagtg cttctttgcc gcgttctacc tggcactcag    180

tgctgatgtg ccaccagctt tgctcagaca cctcttcaat tgtggcaggc caggcaactc    240

accaatggcc aggctcctgc ccacgatgtg catccaggcc tcggagggaa aggacagcag    300

cgtggcagct ttgctgcaga aggccgagcc gcacaacctt cagatcacag cagccttcct    360

ggcagggctg ttgtcccggg agcactgggg cctgctggct gagtgccaga catctgagaa    420

ggccctgctc cggcgccagg cctgtgcccg ctggtgtctg gcccgcagcc tccgcaagca    480

cttccactcc atcccgccag ctgcaccggg tgaggccaag agcgtgcatg ccatgcccgg    540

gttcatctgg ctcatccgga gcctgtacga gatgcaggag gagcggctgg ctcggaaggc    600

tgcacgtggc ctgaatgttg ggcacctcaa gttgacattt tgcagtgtgg gccccactga    660

gtgtgctgcc ctggcctttg tgctgcagca cctccggcgg cccgtggccc tgcagctgga    720

ctacaactct gtgggtgaca ttggcgtgga gcagctgctg ccttgccttg gtgtctgcaa    780

ggctctgtag tgagtgttac tgggcattgc tgttcaggta tgggggagca ccatcaaggc    840

taagtgtggg agcaccgagc tgggctctag aagtctgggc ccagcttcgc ctctgccacc    900

ctgctttgca acactgccca gatcccttcc cttctgggcc ttaatttcaa tatgtgatga    960

tgacagccac actttattga ctggcctatg tgctgggtct ggtgctatgc tttccggaat   1020

gacctcatct aatctctaca accaccctgg cggattctgg ggcaacagag tgggtgacga   1080

gggggcccag gccctggctg aagccttggg tgatcaccag agcttgaggt ggctcagcct   1140

ggtggggaac aacattggca gtgtgggtgc ccaagccttg gcactgatgc tggcaaagaa   1200

cgtcatgcta g                                                        1211


<210>  3260
<211>  67
<212>  PRT
<213>  Homo sapiens

<400>  3260


Met Leu Ser Gly Met Thr Ser Ser Asn Leu Tyr Asn His Pro Gly Gly 
1               5                   10                  15      


Phe Trp Gly Asn Arg Val Gly Asp Glu Gly Ala Gln Ala Leu Ala Glu 
            20                  25                  30          


Ala Leu Gly Asp His Gln Ser Leu Arg Trp Leu Ser Leu Val Gly Asn 
        35                  40                  45              


Asn Ile Gly Ser Val Gly Ala Gln Ala Leu Ala Leu Met Leu Ala Lys 
    50                  55                  60                  


Asn Val Met 
65          

<210>  3261
<211>  1059
<212>  DNA
<213>  Homo sapiens

<400>  3261
gggcatgtgc tgctacgtgt tctcagccca gcagctccag gcagcacagg tcagccctga     60

tgacatttct cttggcttcc tggtgcgtgc caaaggtgtc gtgccaggga gtacggcgcc    120

cctggaattc cttcacatca ctttccagtg cttctttgcc gcgttctacc tggcactcag    180

tgctgatgtg ccaccagctt tgctcagaca cctcttcaat tgtggcaggc caggcaactc    240

accaatggcc aggctcctgc ccacgatgtg catccaggcc tcggagggaa aggacagcag    300

cgtggcagct ttgctgcaga aggccgagcc gcacaacctt cagatcacag cagccttcct    360

ggcagggctg ttgtcccggg agcactgggg cctgctggct gagtgccaga catctgagaa    420

ggccctgctc cggcgccagg cctgtgcccg ctggtgtctg gcccgcagcc tccgcaagca    480

cttccactcc atcccgccag ctgcaccggg tgaggccaag agcgtgcatg ccatgcccgg    540

gttcatctgg ctcatccgga gcctgtacga gatgcaggag gagcggctgg ctcggaaggc    600

tgcacgtggc ctgaatgttg ggcacctcaa gttgacattt tgcagtgtgg gccccactga    660

gtgtgctgcc ctggcctttg tgctgcagca cctccggcgg cccgtggccc tgcagctgga    720

ctacaactct gtgggtgaca ttggcgtgga gcagctgctg ccttgccttg gtgtctgcaa    780

ggctctgtag tgagtgttac tgggcattgc tgttcaggct ggggaataac tacatcactg    840

ccgcgggagc ccaagtgctg gccgaggggc tccgaggcaa cacctccttg cagttcctgg    900

gattctgggg caacagagtg ggtgacgagg gggcccaggc cctggctgaa gccttgggtg    960

atcaccagag cttgaggtgg ctcagcctgg tggggaacaa cattggcagt gtgggtgccc   1020

aagccttggc actgatgctg gcaaagaacg tcatgctag                          1059


<210>  3262
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  3262


Met Cys Cys Tyr Val Phe Ser Ala Gln Gln Leu Gln Ala Ala Gln Val 
1               5                   10                  15      


Ser Pro Asp Asp Ile Ser Leu Gly Phe Leu Val Arg Ala Lys Gly Val 
            20                  25                  30          


Val Pro Gly Ser Thr Ala Pro Leu Glu Phe Leu His Ile Thr Phe Gln 
        35                  40                  45              


Cys Phe Phe Ala Ala Phe Tyr Leu Ala Leu Ser Ala Asp Val Pro Pro 
    50                  55                  60                  


Ala Leu Leu Arg His Leu Phe Asn Cys Gly Arg Pro Gly Asn Ser Pro 
65                  70                  75                  80  


Met Ala Arg Leu Leu Pro Thr Met Cys Ile Gln Ala Ser Glu Gly Lys 
                85                  90                  95      


Asp Ser Ser Val Ala Ala Leu Leu Gln Lys Ala Glu Pro His Asn Leu 
            100                 105                 110         


Gln Ile Thr Ala Ala Phe Leu Ala Gly Leu Leu Ser Arg Glu His Trp 
        115                 120                 125             


Gly Leu Leu Ala Glu Cys Gln Thr Ser Glu Lys Ala Leu Leu Arg Arg 
    130                 135                 140                 


Gln Ala Cys Ala Arg Trp Cys Leu Ala Arg Ser Leu Arg Lys His Phe 
145                 150                 155                 160 


His Ser Ile Pro Pro Ala Ala Pro Gly Glu Ala Lys Ser Val His Ala 
                165                 170                 175     


Met Pro Gly Phe Ile Trp Leu Ile Arg Ser Leu Tyr Glu Met Gln Glu 
            180                 185                 190         


Glu Arg Leu Ala Arg Lys Ala Ala Arg Gly Leu Asn Val Gly His Leu 
        195                 200                 205             


Lys Leu Thr Phe Cys Ser Val Gly Pro Thr Glu Cys Ala Ala Leu Ala 
    210                 215                 220                 


Phe Val Leu Gln His Leu Arg Arg Pro Val Ala Leu Gln Leu Asp Tyr 
225                 230                 235                 240 


Asn Ser Val Gly Asp Ile Gly Val Glu Gln Leu Leu Pro Cys Leu Gly 
                245                 250                 255     


Val Cys Lys Ala Leu 
            260     

<210>  3263
<211>  975
<212>  DNA
<213>  Homo sapiens

<400>  3263
gggcatgtgc tgctacgtgt tctcagccca gcagctccag gcagcacagg tcagccctga     60

tgacatttct cttggcttcc tggtgcgtgc caaaggtgtc gtgccaggga gtacggcgcc    120

cctggaattc cttcacatca ctttccagtg cttctttgcc gcgttctacc tggcactcag    180

tgctgatgtg ccaccagctt tgctcagaca cctcttcaat tgtggcaggc caggcaactc    240

accaatggcc aggctcctgc ccacgatgtg catccaggcc tcggagggaa aggacagcag    300

cgtggcagct ttgctgcaga aggccgagcc gcacaacctt cagatcacag cagccttcct    360

ggcagggctg ttgtcccggg agcactgggg cctgctggct gagtgccaga catctgagaa    420

ggccctgctc cggcgccagg cctgtgcccg ctggtgtctg gcccgcagcc tccgcaagca    480

cttccactcc atcccgccag ctgcaccggg tgaggccaag agcgtgcatg ccatgcccgg    540

gttcatctgg ctcatccgga gcctgtacga gatgcaggag gagcggctgg ctcggaaggc    600

tgcacgtggc ctgaatgttg ggcacctcaa gttgacattt tgcagtgtgg gccccactga    660

gtgtgctgcc ctggcctttg tgctgcagca cctccggcgg cccgtggccc tgcagctgga    720

ctacaactct gtgggtgaca ttggcgtgga gcagctgctg ccttgccttg gtgtctgcaa    780

ggctctgtag tgagtgttac tgggcattgc tgttcagatt ctggggcaac agagtgggtg    840

acgagggggc ccaggccctg gctgaagcct tgggtgatca ccagagcttg aggtggctca    900

gcctggtggg gaacaacatt ggcagtgtgg gtgcccaagc cttggcactg atgctggcaa    960

agaacgtcat gctag                                                     975


<210>  3264
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  3264


Met Cys Cys Tyr Val Phe Ser Ala Gln Gln Leu Gln Ala Ala Gln Val 
1               5                   10                  15      


Ser Pro Asp Asp Ile Ser Leu Gly Phe Leu Val Arg Ala Lys Gly Val 
            20                  25                  30          


Val Pro Gly Ser Thr Ala Pro Leu Glu Phe Leu His Ile Thr Phe Gln 
        35                  40                  45              


Cys Phe Phe Ala Ala Phe Tyr Leu Ala Leu Ser Ala Asp Val Pro Pro 
    50                  55                  60                  


Ala Leu Leu Arg His Leu Phe Asn Cys Gly Arg Pro Gly Asn Ser Pro 
65                  70                  75                  80  


Met Ala Arg Leu Leu Pro Thr Met Cys Ile Gln Ala Ser Glu Gly Lys 
                85                  90                  95      


Asp Ser Ser Val Ala Ala Leu Leu Gln Lys Ala Glu Pro His Asn Leu 
            100                 105                 110         


Gln Ile Thr Ala Ala Phe Leu Ala Gly Leu Leu Ser Arg Glu His Trp 
        115                 120                 125             


Gly Leu Leu Ala Glu Cys Gln Thr Ser Glu Lys Ala Leu Leu Arg Arg 
    130                 135                 140                 


Gln Ala Cys Ala Arg Trp Cys Leu Ala Arg Ser Leu Arg Lys His Phe 
145                 150                 155                 160 


His Ser Ile Pro Pro Ala Ala Pro Gly Glu Ala Lys Ser Val His Ala 
                165                 170                 175     


Met Pro Gly Phe Ile Trp Leu Ile Arg Ser Leu Tyr Glu Met Gln Glu 
            180                 185                 190         


Glu Arg Leu Ala Arg Lys Ala Ala Arg Gly Leu Asn Val Gly His Leu 
        195                 200                 205             


Lys Leu Thr Phe Cys Ser Val Gly Pro Thr Glu Cys Ala Ala Leu Ala 
    210                 215                 220                 


Phe Val Leu Gln His Leu Arg Arg Pro Val Ala Leu Gln Leu Asp Tyr 
225                 230                 235                 240 


Asn Ser Val Gly Asp Ile Gly Val Glu Gln Leu Leu Pro Cys Leu Gly 
                245                 250                 255     


Val Cys Lys Ala Leu 
            260     

<210>  3265
<211>  1115
<212>  DNA
<213>  Homo sapiens

<400>  3265
gggcatgtgc tgctacgtgt tctcagccca gcagctccag gcagcacagg tcagccctga     60

tgacatttct cttggcttcc tggtgcgtgc caaaggtgtc gtgccaggga gtacggcgcc    120

cctggaattc cttcacatca ctttccagtg cttctttgcc gcgttctacc tggcactcag    180

tgctgatgtg ccaccagctt tgctcagaca cctcttcaat tgtggcaggc caggcaactc    240

accaatggcc aggctcctgc ccacgatgtg catccaggcc tcggagggaa aggacagcag    300

cgtggcagct ttgctgcaga aggccgagcc gcacaacctt cagatcacag cagccttcct    360

ggcagggctg ttgtcccggg agcactgggg cctgctggct gagtgccaga catctgagaa    420

ggccctgctc cggcgccagg cctgtgcccg ctggtgtctg gcccgcagcc tccgcaagca    480

cttccactcc atcccgccag ctgcaccggg tgaggccaag agcgtgcatg ccatgcccgg    540

gttcatctgg ctcatccgga gcctgtacga gatgcaggag gagcggctgg ctcggaaggc    600

tgcacgtggc ctgaatgttg ggcacctcaa gttgacattt tgcagtgtgg gccccactga    660

gtgtgctgcc ctggcctttg tgctgcagca cctccggcgg cccgtggccc tgcagctgga    720

ctacaactct gtgggtgaca ttggcgtgga gcagctgctg ccttgccttg gtgtctgcaa    780

ggctctgtat ttgcgcgata acaatatctc agaccgaggc atctgcaagc tcattgaatg    840

tgctcttcac tgcgagcaat tgcagaagtt agctctattc aacaacaaat tgactgacgg    900

ctgtgcacac tccatggcta agctccttgc atgcaggcag aacttcttgg cattgagatt    960

ctggggcaac agagtgggtg acgagggggc ccaggccctg gctgaagcct tgggtgatca   1020

ccagagcttg aggtggctca gcctggtggg gaacaacatt ggcagtgtgg gtgcccaagc   1080

cttggcactg atgctggcaa agaacgtcat gctag                              1115


<210>  3266
<211>  369
<212>  PRT
<213>  Homo sapiens

<400>  3266


Met Cys Cys Tyr Val Phe Ser Ala Gln Gln Leu Gln Ala Ala Gln Val 
1               5                   10                  15      


Ser Pro Asp Asp Ile Ser Leu Gly Phe Leu Val Arg Ala Lys Gly Val 
            20                  25                  30          


Val Pro Gly Ser Thr Ala Pro Leu Glu Phe Leu His Ile Thr Phe Gln 
        35                  40                  45              


Cys Phe Phe Ala Ala Phe Tyr Leu Ala Leu Ser Ala Asp Val Pro Pro 
    50                  55                  60                  


Ala Leu Leu Arg His Leu Phe Asn Cys Gly Arg Pro Gly Asn Ser Pro 
65                  70                  75                  80  


Met Ala Arg Leu Leu Pro Thr Met Cys Ile Gln Ala Ser Glu Gly Lys 
                85                  90                  95      


Asp Ser Ser Val Ala Ala Leu Leu Gln Lys Ala Glu Pro His Asn Leu 
            100                 105                 110         


Gln Ile Thr Ala Ala Phe Leu Ala Gly Leu Leu Ser Arg Glu His Trp 
        115                 120                 125             


Gly Leu Leu Ala Glu Cys Gln Thr Ser Glu Lys Ala Leu Leu Arg Arg 
    130                 135                 140                 


Gln Ala Cys Ala Arg Trp Cys Leu Ala Arg Ser Leu Arg Lys His Phe 
145                 150                 155                 160 


His Ser Ile Pro Pro Ala Ala Pro Gly Glu Ala Lys Ser Val His Ala 
                165                 170                 175     


Met Pro Gly Phe Ile Trp Leu Ile Arg Ser Leu Tyr Glu Met Gln Glu 
            180                 185                 190         


Glu Arg Leu Ala Arg Lys Ala Ala Arg Gly Leu Asn Val Gly His Leu 
        195                 200                 205             


Lys Leu Thr Phe Cys Ser Val Gly Pro Thr Glu Cys Ala Ala Leu Ala 
    210                 215                 220                 


Phe Val Leu Gln His Leu Arg Arg Pro Val Ala Leu Gln Leu Asp Tyr 
225                 230                 235                 240 


Asn Ser Val Gly Asp Ile Gly Val Glu Gln Leu Leu Pro Cys Leu Gly 
                245                 250                 255     


Val Cys Lys Ala Leu Tyr Leu Arg Asp Asn Asn Ile Ser Asp Arg Gly 
            260                 265                 270         


Ile Cys Lys Leu Ile Glu Cys Ala Leu His Cys Glu Gln Leu Gln Lys 
        275                 280                 285             


Leu Ala Leu Phe Asn Asn Lys Leu Thr Asp Gly Cys Ala His Ser Met 
    290                 295                 300                 


Ala Lys Leu Leu Ala Cys Arg Gln Asn Phe Leu Ala Leu Arg Phe Trp 
305                 310                 315                 320 


Gly Asn Arg Val Gly Asp Glu Gly Ala Gln Ala Leu Ala Glu Ala Leu 
                325                 330                 335     


Gly Asp His Gln Ser Leu Arg Trp Leu Ser Leu Val Gly Asn Asn Ile 
            340                 345                 350         


Gly Ser Val Gly Ala Gln Ala Leu Ala Leu Met Leu Ala Lys Asn Val 
        355                 360                 365             


Met 
    

<210>  3267
<211>  574
<212>  DNA
<213>  Homo sapiens

<400>  3267
agctccattt tcaaatgtat ttattttgtc tctttagttt gcgcgataac aatatctcag     60

accgaggcat ctgcaagctc attgaatgtg ctcttcactg cgagcaattg cagaagttag    120

ctctattcaa caacaaattg actgacggct gtgcacactc catggctaag ctccttgcat    180

gcaggcagaa cttcttggca ttgaggctgg ggaataacta catcactgcc gcgggagccc    240

aagtgctggc cgaggggctc cgaggcaaca cctccttgca gttcctggga ttctggggca    300

acagagtggg tgacgagggg gcccaggccc tggctgaagc cttgggtgat caccagagct    360

tgaggtggct cagcctggtg gggaacaaca ttggcagtgt gggtgcccaa gccttggcac    420

tgatgctggc aaagaacgtc atgctagaag aactctgcct ggaggagaac catctccagg    480

atgaaggtgt atgttctctc gcagaaggac tgaagaaaaa ttcaagtttg aaaatcctga    540

agttgtccaa taactgcatc acctacctag gggc                                574


<210>  3268
<211>  185
<212>  PRT
<213>  Homo sapiens

<400>  3268


Met Tyr Leu Phe Cys Leu Phe Ser Leu Arg Asp Asn Asn Ile Ser Asp 
1               5                   10                  15      


Arg Gly Ile Cys Lys Leu Ile Glu Cys Ala Leu His Cys Glu Gln Leu 
            20                  25                  30          


Gln Lys Leu Ala Leu Phe Asn Asn Lys Leu Thr Asp Gly Cys Ala His 
        35                  40                  45              


Ser Met Ala Lys Leu Leu Ala Cys Arg Gln Asn Phe Leu Ala Leu Arg 
    50                  55                  60                  


Leu Gly Asn Asn Tyr Ile Thr Ala Ala Gly Ala Gln Val Leu Ala Glu 
65                  70                  75                  80  


Gly Leu Arg Gly Asn Thr Ser Leu Gln Phe Leu Gly Phe Trp Gly Asn 
                85                  90                  95      


Arg Val Gly Asp Glu Gly Ala Gln Ala Leu Ala Glu Ala Leu Gly Asp 
            100                 105                 110         


His Gln Ser Leu Arg Trp Leu Ser Leu Val Gly Asn Asn Ile Gly Ser 
        115                 120                 125             


Val Gly Ala Gln Ala Leu Ala Leu Met Leu Ala Lys Asn Val Met Leu 
    130                 135                 140                 


Glu Glu Leu Cys Leu Glu Glu Asn His Leu Gln Asp Glu Gly Val Cys 
145                 150                 155                 160 


Ser Leu Ala Glu Gly Leu Lys Lys Asn Ser Ser Leu Lys Ile Leu Lys 
                165                 170                 175     


Leu Ser Asn Asn Cys Ile Thr Tyr Leu 
            180                 185 

<210>  3269
<211>  563
<212>  DNA
<213>  Homo sapiens

<400>  3269
aacaacagat ctgggaaggc tgcagagggc acgatggggt ctggatcgag ggcggctgag     60

accagaggga aaggtgtgac cctgagtcac cctcgctgtc ccggggaaac cacctcccag    120

gacagctgcc tactgtggct cctgcctgga attgtcacac tgctgtgcaa acagcgtccc    180

gctgcccctt tccctttgct gggggaaaat gaagttgtgg gagccgctga gtaaactaga    240

cctagcagcg agggcacctg atgtggctgc tgcctcccgg gcaggtcttc aatgctttct    300

tcctcttcca ggctggggaa taactacatc actgccgcgg gagcccaagt gctggccgag    360

gggctccgag gcaacacctc cttgcagttc ctgggattct ggggcaacag agtgggtgac    420

gagggggccc aggccctggc tgaagccttg ggtgatcacc agagcttgag gtggctcagc    480

ctggtgggga acaacattgg cagtgtgggt gcccaagcct tggcactgat gctggcaaag    540

aacgtcatgc tagaagaact ctg                                            563


<210>  3270
<211>  89
<212>  PRT
<213>  Homo sapiens

<400>  3270


Met Leu Ser Ser Ser Ser Arg Leu Gly Asn Asn Tyr Ile Thr Ala Ala 
1               5                   10                  15      


Gly Ala Gln Val Leu Ala Glu Gly Leu Arg Gly Asn Thr Ser Leu Gln 
            20                  25                  30          


Phe Leu Gly Phe Trp Gly Asn Arg Val Gly Asp Glu Gly Ala Gln Ala 
        35                  40                  45              


Leu Ala Glu Ala Leu Gly Asp His Gln Ser Leu Arg Trp Leu Ser Leu 
    50                  55                  60                  


Val Gly Asn Asn Ile Gly Ser Val Gly Ala Gln Ala Leu Ala Leu Met 
65                  70                  75                  80  


Leu Ala Lys Asn Val Met Leu Glu Glu 
                85                  

<210>  3271
<211>  384
<212>  DNA
<213>  Homo sapiens

<400>  3271
agagacgggg aatggcctgg atggatgagt cgagacatgg ggaaagctgc ttcctgaatt     60

atgtgttctg tgtactcctc ttcatcagag cagtggtaag gggtcttttg tgagaggccg    120

ggcctctcca ccaaaaggca ctcagttaac aagcacatcc atgggcccca ctgacccaca    180

cggaagcctg ggaggatcag cagaggccag tcccatacta tggaggaggg gctgtccttg    240

tacatcctgg gattgaatct tgggaagaag tcaatggtga cctatggtgt tcccagaaaa    300

caagttcagc cttaggcagg acagggctca ttttgaagag gctgccaaca catgtcaccc    360

agcctctggg gcccaaactc acag                                           384


<210>  3272
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  3272


Met Glu Glu Gly Leu Ser Leu Tyr Ile Leu Gly Leu Asn Leu Gly Lys 
1               5                   10                  15      


Lys Ser Met Val Thr Tyr Gly Val Pro Arg Lys Gln Val Gln Pro 
            20                  25                  30      

<210>  3273
<211>  515
<212>  DNA
<213>  Homo sapiens

<400>  3273
ccgttctcat ctacatctgg attctccaac aaagctggga aaaaaacgat ccaagggaag     60

ccaatcaaag agcctggatt gccagtcttc cctgctgcga tctccgcctg cgattctcca    120

ggggaaatgt cctttatgac cttacagctc acctggaacc ctccacctag ggcccgaggc    180

agcacatcct ctcgtgcccg ggcacttcca ggcattgccc tgagtactgg gcacttcaca    240

cactgggctg gaccactcac cggagtgaat aaggaggctt gaagctgtcc tggtacaaca    300

atggaatgaa gcgctagtct cagctcagcc acttggaata tgactccaac tctcacattt    360

ctgtggggtg tattcatttc agctttttgt ttggtgctat ggggagggaa gggccctcag    420

actggcatcc tttttcttcc aggatgatga tgaatattat gaaagtctga ggctgttttt    480

aaaattctgc tctaatacgt tgtttttctg tgcat                               515


<210>  3274
<211>  51
<212>  PRT
<213>  Homo sapiens

<400>  3274


Met Ser Phe Met Thr Leu Gln Leu Thr Trp Asn Pro Pro Pro Arg Ala 
1               5                   10                  15      


Arg Gly Ser Thr Ser Ser Arg Ala Arg Ala Leu Pro Gly Ile Ala Leu 
            20                  25                  30          


Ser Thr Gly His Phe Thr His Trp Ala Gly Pro Leu Thr Gly Val Asn 
        35                  40                  45              


Lys Glu Ala 
    50      

<210>  3275
<211>  640
<212>  DNA
<213>  Homo sapiens

<400>  3275
ctaaggaact ccgggtggct gtgtagaacc atcctcaccc tagaaagggg gaaactgaaa     60

gaaaaagcag aacacgccat taacaaggcc agaaccccga ctgccattcc tggacgggag    120

ccaccaacac ccgcaaaatc gatcgattca gcctgggacg cttgctgttt ccgaacctct    180

gttgccacct atcccagttt ggagggaatt ttcccaagga tggtgaagaa gggatttcca    240

cacgccgcct cactcagccc cgcacccctg gccaccagcc aggacttagg gtgtagttaa    300

ggatctttca attagaaggg aggcttctga ttcccaaaag cactcaaaat atttaaggaa    360

gtgcttttta taatcagtcc tagagccttg ctgcactgga tactcctgtt aattaatttc    420

ttctcctttg acattttaag tgctaattat aggagaaggt gattaacact gagaaaggag    480

gaggggtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtt tttaatcatg acacaaattt    540

cccccagtgg aaagtgacat gtttctggag atccagggaa tttaaaccaa tgaatacata    600

aaaacagtca catgagtgat gactaacagt agcagtagac                          640


<210>  3276
<211>  70
<212>  PRT
<213>  Homo sapiens

<400>  3276


Gln Gly Gln Asn Pro Asp Cys His Ser Trp Thr Gly Ala Thr Asn Thr 
1               5                   10                  15      


Arg Lys Ile Asp Arg Phe Ser Leu Gly Arg Leu Leu Phe Pro Asn Leu 
            20                  25                  30          


Cys Cys His Leu Ser Gln Phe Gly Gly Asn Phe Pro Lys Asp Gly Glu 
        35                  40                  45              


Glu Gly Ile Ser Thr Arg Arg Leu Thr Gln Pro Arg Thr Pro Gly His 
    50                  55                  60                  


Gln Pro Gly Leu Arg Val 
65                  70  

<210>  3277
<211>  6044
<212>  DNA
<213>  Homo sapiens

<400>  3277
gggggcgggc ccaggtagca ggtttggctg cgcgggggcc gcgcgtcgga gtttccccct     60

ttctagggtg aggatggttc tacacagcca cccggagttc cttagttgaa aggtgcgccc    120

tgctgtgaca gaatgtggta attgtaatct ttaacatttt catgtaaaac atatttcctg    180

atcatctttc cattgtcttc atggaaaatt gataaatatt tgtgccttcc aactctcgtc    240

ttggttgaat gacttcatct taatacaaca tggacaccac gttgctgaaa acatgctttg    300

ggactgccac tgaatttatc ttttgcggtt ttatgacaaa gttattagta gtttcccttt    360

tttgaattag tattttgaag ttaatatcac aatgagttca ggcttatgga gccaagaaaa    420

agtcacttca ccctactggg aagagcggat tttttacttg cttcttcaag aatgcagcgt    480

tacagacaaa caaacacaaa agctccttaa agtaccgaag ggaagtatag gacagtatat    540

tcaagatcgt tctgtggggc attcaaggat tccttctgca aaaggcaaga aaaatcagat    600

tggattaaaa attctagagc aacctcatgc agttctcttt gttgatgaaa aggatgttgt    660

agagataaat gaaaagttca cagagttact tttggcaatt accaattgtg aggagaggtt    720

cagcctgttt aaaaacagaa acagactaag taaaggcctc caaatagacg tgggctgtcc    780

tgtgaaagta cagctgagat ctggggaaga aaaatttcct ggagttgtac gcttcagagg    840

acccctgtta gcagagagga cagtctccgg aatattcttt ggagttgaat tgctggaaga    900

aggtcgtggt caaggtttca ctgacggggt gtaccaaggg aaacagcttt ttcagtgtga    960

tgaagattgt ggcgtgtttg ttgcattgga caagctagaa ctcatagaag atgatgacac   1020

tgcattggaa agtgattacg caggtcctgg ggacacaatg caggtcgaac ttcctccttt   1080

ggaaataaac tccagagttt ctttgaaggt tggagaaaca atagaatctg gaacagttat   1140

attctgtgat gttttgccag gaaaagaaag cttaggatat tttgttggtg tggacatgga   1200

taaccctatt ggcaactggg atggaagatt tgatggagtg cagctttgta gttttgcgtg   1260

tgttgaaagt acaattctat tgcacatcaa tgatatcatc ccagagagtg tgacgcagga   1320

aaggaggcct cccaaacttg cctttatgtc aagaggtgtt ggggacaaag gttcatccag   1380

tcataataaa ccaaaggcta caggatctac ctcagaccct ggaaatagaa acagatctga   1440

attattttat accttaaatg ggtcttctgt tgactcacaa ccacaatcca aatcaaaaaa   1500

tacatggtac attgatgaag ttgcagaaga ccctgcaaaa tctcttacag agatatctac   1560

agactttgac cgttcttcac caccactcca gcctcctcct gtgaactcac tgaccaccga   1620

gaacagattc cactctttac cattcagtct caccaagatg cccaatacca atggaagtat   1680

tggccacagt ccactttctc tgtcagccca gtctgtaatg gaagagctaa acactgcacc   1740

cgtccaagag agtccaccct tggccatgcc tcctgggaac tcacatggtc tagaagtggg   1800

ctcattggct gaagttaagg agaaccctcc tttctatggg gtaatccgtt ggatcggtca   1860

gccaccagga ctgaatgaag tgctcgctgg actggaactg gaagatgagt gtgcaggctg   1920

tacggatgga accttcagag gcactcggta tttcacctgt gccctgaaga aggcgctgtt   1980

tgtgaaactg aagagctgca ggcctgactc taggtttgca tcattgcagc cggtttccaa   2040

tcagattgag cgctgtaact ctttagcatt tggaggctac ttaagtgaag tagtagaaga   2100

aaatactcca ccaaaaatgg aaaaagaagg cttggagata atgattggga agaagaaagg   2160

catccagggt cattacaatt cttgttactt agactcaacc ttattctgct tatttgcttt   2220

tagttctgtt ctggacactg tgttacttag acccaaagaa aagaacgatg tagaatatta   2280

tagtgaaacc caagagctac tgaggacaga aattgttaat cctctgagaa tatatggata   2340

tgtgtgtgcc acaaaaatta tgaaactgag gaaaatactt gaaaaggtgg aggctgcatc   2400

aggatttacc tctgaagaaa aagatcctga ggaattcttg aatattctgt ttcatcatat   2460

tttaagggta gaacctttgc taaaaataag atcagcaggt caaaaggtac aagattgtta   2520

cttctatcaa atttttatgg aaaaaaatga gaaagttggc gttcccacaa ttcagcagtt   2580

gttagaatgg tcttttatca acagtaacct gaaatttgca gaggcaccat catgtctgat   2640

tattcagatg cctcgatttg gaaaagactt taaactattt aaaaaaattt ttccttctct   2700

ggaattaaat ataacagatt tacttgaaga cactcccaga cagtgccgga tatgtggagg   2760

gcttgcaatg tatgagtgta gagaatgcta cgacgatccg gacatctcag ctggaaaaat   2820

caagcagttt tgtaaaacct gcaacactca agtccacctt catccgaaga ggctgaatca   2880

taaatataac ccagtgtcac ttcccaaaga cttacccgac tgggactgga gacacggctg   2940

catcccttgc cagaatatgg agttatttgc tgttctctgc atagaaacaa gccactatgt   3000

tgcttttgtg aagtatggga aggacgattc tgcctggctc ttctttgaca gcatggccga   3060

tcgggatggt ggtcagaatg gcttcaacat tcctcaagtc accccatgcc cagaagtagg   3120

agagtacttg aagatgtctc tggaagacct gcattccttg gactccagga gaatccaagg   3180

ctgtgcacga agactgcttt gtgatgcata tatgtgcatg taccagagtc caacaatgag   3240

tttgtacaaa taactggggt catcgggaaa ggcaaagaaa ctgaaggcag agtcctaacg   3300

ttgcatctta ttcgagctgg cagttctgtt cacgtccatt gccggcaatg gatgtctttg   3360

tggtgatgat ccttcagaaa aggatgcctc tgtttaaaaa caaattgctt ttgtgtccct   3420

gaagtattta ataagaagca ttttgcactc tagaaagtat gtttgtgttg gttttttaag   3480

aagtctaaat gaagttatta atacctgaag ctttaagtta agtgcattga tcatatgata   3540

tttttggaag catacaattt taattgtgga agtttaaagc ctcttttagt ccattgagaa   3600

tgtaaataaa tgtgtcttct ttatggacca aggatatgaa atcatttttc ttttgtagct   3660

aacggttgcc ttgaggaaga aataatttgg ttttattaag agtctactct caatccagtt   3720

attagagatg tactgagttt gatttgttaa tcctttctat atactgctga tcttgcatgt   3780

ctacaatctg ctcagttttt ctgtgtttct gcaatagtgg tcagaaaaat acttaaattc   3840

ccttaatggt gttgttttct atttgttctg gttttgagat aaatgagtga ttctgtcccc   3900

aaatgtccat ttttgaagtg attttcctgg aggattaggg tatttagcag ttgaagctct   3960

tcattcatag tagttactgt cagctaacag gttttttaag gcttttaact attaatattt   4020

tatggaatgg ggcaaagtaa attgatgaaa gaattggagt gataatagtc ctttacaaac   4080

atacagtcca taagaaaatg aatttggcat atagaattat tacaatttcc tgggagagat   4140

ggatatttaa acctctatta ttttagacaa gactgtctag aacttaagtt tgatctgtca   4200

gccagtactc ccattaaatt cagtgtagtt tcacttgata gaatcagata tgttatcgaa   4260

atgttagcag cagcttcatc ctccttctga ttaaagtaag tagaaatggg atgttttgtt   4320

taataacagc catagtgtgt gtttagacca cagcggatgt tgtagaccag gaccatagat   4380

gatacatgtc agtgctgtgg aatgtgcatt ctctgagtgt tgttttgtgg tatcattgtc   4440

tttcctgaat gactttctaa ctgtgcagaa aggcagaaaa gtcatcatat gtatatgtca   4500

tatgacttta taaaatattt aatgtgacaa aaagtggaaa gaatctttac aaaccctgca   4560

attacttttt taaaggcact tttactcttt ggttttatca ttccattttg ctaatattta   4620

ctagctttat aaattacagt aaggtacaaa aactcatctt gtaatatttt catttttgaa   4680

gtgaaaaagt acatatattt tgcacaaggt tttatactgc taagtgcttg gttggggtgg   4740

tgagatgatg attagatcag gggtgaggct gagagactct gggtttaggg ctagccctgc   4800

ctccatctcc cttgggtaaa atgaagggtg tggggtaaaa gatgcataag gccttttcta   4860

gctctgacag cctagaagtc caatcaccct gtaataaata tgtgttgaat gaagaaatgg   4920

gtgaatgagc ttgtcaatgt gattttaaaa aattgactac ctggaggaat gattaggaat   4980

ctaaatgaag ccagccctcg gtatctgcag gtttctcatc catggattca accaactgca   5040

aatggaaaat acgatttttt ttaaaaaaag gatggttaca tccgtattga acatgtacag   5100

acttttttct tgtcattatt ctctgaacaa tacaagaact ctttatgtag catttacatt   5160

tattaggtat tataagtaat ctagagatta tttaattaaa atatacagga ggatgtgtgt   5220

cagttatatg caaattctgt accattttgt atcagggaat tgagcatctt cagatgttgg   5280

tatctgcagg gatcctggaa ccaaacccct gcagatacta agggctgacg atctaggtaa   5340

gactggattt aacagttgga aaaaaaaaaa aaaaaggaga gagaagacag ttcctttcct   5400

gtagaaatta aaacaaaata caaattgagg aagctctgct acccaggctg tcatggtaga   5460

gaacttgaag aagacctgtt tggatggaca cctggtttca aaagtcaggt gtggagactg   5520

ttaaatggga gggcctcatc cataaatgat ttctggcaac gtcttcttca ggtggagctt   5580

gacgtctttt taatgttact tggggaggga gtgctcatta agggatgcca gggccagctc   5640

tggtggttcc tggggaggct gcgtccttcc ctgcttctgc atgtcatgag gcagcaggaa   5700

ggtttcccct gcacctgtct gtcctggctc cctctgggta gccccctact gttctgtgct   5760

tcagcacagc ctggtttgtc aagaggcaca tagttggggc tgggctgcat ggcacagggg   5820

cttatgtgcc tgctggttat ttaattttca gccttaagtt ttctttaata ttttcctgtt   5880

ggctatttaa aggttttggt tatcttttat tccttatcta caatcaagat gacaatgtaa   5940

ttgaattatc ttatttataa cacggttcgt gattcatgat tcatgattac aagtagaaaa   6000

tatgtcatgt tcctcacctc caaataaata tgtgtgtgtc tgtg                    6044


<210>  3278
<211>  953
<212>  PRT
<213>  Homo sapiens

<400>  3278


Met Ser Ser Gly Leu Trp Ser Gln Glu Lys Val Thr Ser Pro Tyr Trp 
1               5                   10                  15      


Glu Glu Arg Ile Phe Tyr Leu Leu Leu Gln Glu Cys Ser Val Thr Asp 
            20                  25                  30          


Lys Gln Thr Gln Lys Leu Leu Lys Val Pro Lys Gly Ser Ile Gly Gln 
        35                  40                  45              


Tyr Ile Gln Asp Arg Ser Val Gly His Ser Arg Ile Pro Ser Ala Lys 
    50                  55                  60                  


Gly Lys Lys Asn Gln Ile Gly Leu Lys Ile Leu Glu Gln Pro His Ala 
65                  70                  75                  80  


Val Leu Phe Val Asp Glu Lys Asp Val Val Glu Ile Asn Glu Lys Phe 
                85                  90                  95      


Thr Glu Leu Leu Leu Ala Ile Thr Asn Cys Glu Glu Arg Phe Ser Leu 
            100                 105                 110         


Phe Lys Asn Arg Asn Arg Leu Ser Lys Gly Leu Gln Ile Asp Val Gly 
        115                 120                 125             


Cys Pro Val Lys Val Gln Leu Arg Ser Gly Glu Glu Lys Phe Pro Gly 
    130                 135                 140                 


Val Val Arg Phe Arg Gly Pro Leu Leu Ala Glu Arg Thr Val Ser Gly 
145                 150                 155                 160 


Ile Phe Phe Gly Val Glu Leu Leu Glu Glu Gly Arg Gly Gln Gly Phe 
                165                 170                 175     


Thr Asp Gly Val Tyr Gln Gly Lys Gln Leu Phe Gln Cys Asp Glu Asp 
            180                 185                 190         


Cys Gly Val Phe Val Ala Leu Asp Lys Leu Glu Leu Ile Glu Asp Asp 
        195                 200                 205             


Asp Thr Ala Leu Glu Ser Asp Tyr Ala Gly Pro Gly Asp Thr Met Gln 
    210                 215                 220                 


Val Glu Leu Pro Pro Leu Glu Ile Asn Ser Arg Val Ser Leu Lys Val 
225                 230                 235                 240 


Gly Glu Thr Ile Glu Ser Gly Thr Val Ile Phe Cys Asp Val Leu Pro 
                245                 250                 255     


Gly Lys Glu Ser Leu Gly Tyr Phe Val Gly Val Asp Met Asp Asn Pro 
            260                 265                 270         


Ile Gly Asn Trp Asp Gly Arg Phe Asp Gly Val Gln Leu Cys Ser Phe 
        275                 280                 285             


Ala Cys Val Glu Ser Thr Ile Leu Leu His Ile Asn Asp Ile Ile Pro 
    290                 295                 300                 


Glu Ser Val Thr Gln Glu Arg Arg Pro Pro Lys Leu Ala Phe Met Ser 
305                 310                 315                 320 


Arg Gly Val Gly Asp Lys Gly Ser Ser Ser His Asn Lys Pro Lys Ala 
                325                 330                 335     


Thr Gly Ser Thr Ser Asp Pro Gly Asn Arg Asn Arg Ser Glu Leu Phe 
            340                 345                 350         


Tyr Thr Leu Asn Gly Ser Ser Val Asp Ser Gln Pro Gln Ser Lys Ser 
        355                 360                 365             


Lys Asn Thr Trp Tyr Ile Asp Glu Val Ala Glu Asp Pro Ala Lys Ser 
    370                 375                 380                 


Leu Thr Glu Ile Ser Thr Asp Phe Asp Arg Ser Ser Pro Pro Leu Gln 
385                 390                 395                 400 


Pro Pro Pro Val Asn Ser Leu Thr Thr Glu Asn Arg Phe His Ser Leu 
                405                 410                 415     


Pro Phe Ser Leu Thr Lys Met Pro Asn Thr Asn Gly Ser Ile Gly His 
            420                 425                 430         


Ser Pro Leu Ser Leu Ser Ala Gln Ser Val Met Glu Glu Leu Asn Thr 
        435                 440                 445             


Ala Pro Val Gln Glu Ser Pro Pro Leu Ala Met Pro Pro Gly Asn Ser 
    450                 455                 460                 


His Gly Leu Glu Val Gly Ser Leu Ala Glu Val Lys Glu Asn Pro Pro 
465                 470                 475                 480 


Phe Tyr Gly Val Ile Arg Trp Ile Gly Gln Pro Pro Gly Leu Asn Glu 
                485                 490                 495     


Val Leu Ala Gly Leu Glu Leu Glu Asp Glu Cys Ala Gly Cys Thr Asp 
            500                 505                 510         


Gly Thr Phe Arg Gly Thr Arg Tyr Phe Thr Cys Ala Leu Lys Lys Ala 
        515                 520                 525             


Leu Phe Val Lys Leu Lys Ser Cys Arg Pro Asp Ser Arg Phe Ala Ser 
    530                 535                 540                 


Leu Gln Pro Val Ser Asn Gln Ile Glu Arg Cys Asn Ser Leu Ala Phe 
545                 550                 555                 560 


Gly Gly Tyr Leu Ser Glu Val Val Glu Glu Asn Thr Pro Pro Lys Met 
                565                 570                 575     


Glu Lys Glu Gly Leu Glu Ile Met Ile Gly Lys Lys Lys Gly Ile Gln 
            580                 585                 590         


Gly His Tyr Asn Ser Cys Tyr Leu Asp Ser Thr Leu Phe Cys Leu Phe 
        595                 600                 605             


Ala Phe Ser Ser Val Leu Asp Thr Val Leu Leu Arg Pro Lys Glu Lys 
    610                 615                 620                 


Asn Asp Val Glu Tyr Tyr Ser Glu Thr Gln Glu Leu Leu Arg Thr Glu 
625                 630                 635                 640 


Ile Val Asn Pro Leu Arg Ile Tyr Gly Tyr Val Cys Ala Thr Lys Ile 
                645                 650                 655     


Met Lys Leu Arg Lys Ile Leu Glu Lys Val Glu Ala Ala Ser Gly Phe 
            660                 665                 670         


Thr Ser Glu Glu Lys Asp Pro Glu Glu Phe Leu Asn Ile Leu Phe His 
        675                 680                 685             


His Ile Leu Arg Val Glu Pro Leu Leu Lys Ile Arg Ser Ala Gly Gln 
    690                 695                 700                 


Lys Val Gln Asp Cys Tyr Phe Tyr Gln Ile Phe Met Glu Lys Asn Glu 
705                 710                 715                 720 


Lys Val Gly Val Pro Thr Ile Gln Gln Leu Leu Glu Trp Ser Phe Ile 
                725                 730                 735     


Asn Ser Asn Leu Lys Phe Ala Glu Ala Pro Ser Cys Leu Ile Ile Gln 
            740                 745                 750         


Met Pro Arg Phe Gly Lys Asp Phe Lys Leu Phe Lys Lys Ile Phe Pro 
        755                 760                 765             


Ser Leu Glu Leu Asn Ile Thr Asp Leu Leu Glu Asp Thr Pro Arg Gln 
    770                 775                 780                 


Cys Arg Ile Cys Gly Gly Leu Ala Met Tyr Glu Cys Arg Glu Cys Tyr 
785                 790                 795                 800 


Asp Asp Pro Asp Ile Ser Ala Gly Lys Ile Lys Gln Phe Cys Lys Thr 
                805                 810                 815     


Cys Asn Thr Gln Val His Leu His Pro Lys Arg Leu Asn His Lys Tyr 
            820                 825                 830         


Asn Pro Val Ser Leu Pro Lys Asp Leu Pro Asp Trp Asp Trp Arg His 
        835                 840                 845             


Gly Cys Ile Pro Cys Gln Asn Met Glu Leu Phe Ala Val Leu Cys Ile 
    850                 855                 860                 


Glu Thr Ser His Tyr Val Ala Phe Val Lys Tyr Gly Lys Asp Asp Ser 
865                 870                 875                 880 


Ala Trp Leu Phe Phe Asp Ser Met Ala Asp Arg Asp Gly Gly Gln Asn 
                885                 890                 895     


Gly Phe Asn Ile Pro Gln Val Thr Pro Cys Pro Glu Val Gly Glu Tyr 
            900                 905                 910         


Leu Lys Met Ser Leu Glu Asp Leu His Ser Leu Asp Ser Arg Arg Ile 
        915                 920                 925             


Gln Gly Cys Ala Arg Arg Leu Leu Cys Asp Ala Tyr Met Cys Met Tyr 
    930                 935                 940                 


Gln Ser Pro Thr Met Ser Leu Tyr Lys 
945                 950             

<210>  3279
<211>  8682
<212>  DNA
<213>  Homo sapiens

<400>  3279
gggggcgggc ccaggtagca ggtttggctg cgcgggggcc gcgcgtcgga gtttccccct     60

ttctagggtg aggatggttc tacacagcca cccggagttc cttagttgaa aggtgcgccc    120

tgctgtgaca gaatgtggta attgtaatct ttaacatttt catgtaaaac atatttcctg    180

atcatctttc cattgtcttc atggaaaatt gataaatatt tgtgccttcc aactctcgtc    240

ttggttgaat gacttcatct taatacaaca tggacaccac gttgctgaaa acatgctttg    300

ggactgccac tgaatttatc ttttgcggtt ttatgacaaa gttattagta gtttcccttt    360

tttgaattag tattttgaag ttaatatcac aatgagttca ggcttatgga gccaagaaaa    420

agtcacttca ccctactggg aagagcggat tttttacttg cttcttcaag aatgcagcgt    480

tacagacaaa caaacacaaa agctccttaa agtaccgaag ggaagtatag gacagtatat    540

tcaagatcgt tctgtggggc attcaaggat tccttctgca aaaggcaaga aaaatcagat    600

tggattaaaa attctagagc aacctcatgc agttctcttt gttgatgaaa aggatgttgt    660

agagataaat gaaaagttca cagagttact tttggcaatt accaattgtg aggagaggtt    720

cagcctgttt aaaaacagaa acagactaag taaaggcctc caaatagacg tgggctgtcc    780

tgtgaaagta cagctgagat ctggggaaga aaaatttcct ggagttgtac gcttcagagg    840

acccctgtta gcagagagga cagtctccgg aatattcttt ggagttgaat tgctggaaga    900

aggtcgtggt caaggtttca ctgacggggt gtaccaaggg aaacagcttt ttcagtgtga    960

tgaagattgt ggcgtgtttg ttgcattgga caagctagaa ctcatagaag atgatgacac   1020

tgcattggaa agtgattacg caggtcctgg ggacacaatg caggtcgaac ttcctccttt   1080

ggaaataaac tccagagttt ctttgaaggt tggagaaaca atagaatctg gaacagttat   1140

attctgtgat gttttgccag gaaaagaaag cttaggatat tttgttggtg tggacatgga   1200

taaccctatt ggcaactggg atggaagatt tgatggagtg cagctttgta gttttgcgtg   1260

tgttgaaagt acaattctat tgcacatcaa tgatatcatc ccagagagtg tgacgcagga   1320

aaggaggcct cccaaacttg cctttatgtc aagaggtgtt ggggacaaag gttcatccag   1380

tcataataaa ccaaaggcta caggatctac ctcagaccct ggaaatagaa acagatctga   1440

attattttat accttaaatg ggtcttctgt tgactcacaa ccacaatcca aatcaaaaaa   1500

tacatggtac attgatgaag ttgcagaaga ccctgcaaaa tctcttacag agatatctac   1560

agactttgac cgttcttcac caccactcca gcctcctcct gtgaactcac tgaccaccga   1620

gaacagattc cactctttac cattcagtct caccaagatg cccaatacca atggaagtat   1680

tggccacagt ccactttctc tgtcagccca gtctgtaatg gaagagctaa acactgcacc   1740

cgtccaagag agtccaccct tggccatgcc tcctgggaac tcacatggtc tagaagtggg   1800

ctcattggct gaagttaagg agaaccctcc tttctatggg gtaatccgtt ggatcggtca   1860

gccaccagga ctgaatgaag tgctcgctgg actggaactg gaagatgagt gtgcaggctg   1920

tacggatgga accttcagag gcactcggta tttcacctgt gccctgaaga aggcgctgtt   1980

tgtgaaactg aagagctgca ggcctgactc taggtttgca tcattgcagc cggtttccaa   2040

tcagattgag cgctgtaact ctttagcatt tggaggctac ttaagtgaag tagtagaaga   2100

aaatactcca ccaaaaatgg aaaaagaagg cttggagata atgattggga agaagaaagg   2160

catccagggt cattacaatt cttgttactt agactcaacc ttattctgct tatttgcttt   2220

tagttctgtt ctggacactg tgttacttag acccaaagaa aagaacgatg tagaatatta   2280

tagtgaaacc caagagctac tgaggacaga aattgttaat cctctgagaa tatatggata   2340

tgtgtgtgcc acaaaaatta tgaaactgag gaaaatactt gaaaaggtgg aggctgcatc   2400

aggatttacc tctgaagaaa aagatcctga ggaattcttg aatattctgt ttcatcatat   2460

tttaagggta gaacctttgc taaaaataag atcagcaggt caaaaggtac aagattgtta   2520

cttctatcaa atttttatgg aaaaaaatga gaaagttggc gttcccacaa ttcagcagtt   2580

gttagaatgg tcttttatca acagtaacct gaaatttgca gaggcaccat catgtctgat   2640

tattcagatg cctcgatttg gaaaagactt taaactattt aaaaaaattt ttccttctct   2700

ggaattaaat ataacagatt tacttgaaga cactcccaga cagtgccgga tatgtggagg   2760

gcttgcaatg tatgagtgta gagaatgcta cgacgatccg gacatctcag ctggaaaaat   2820

caagcagttt tgtaaaacct gcaacactca agtccacctt catccgaaga ggctgaatca   2880

taaatataac ccagtgtcac ttcccaaaga cttacccgac tgggactgga gacacggctg   2940

catcccttgc cagaatatgg agttatttgc tgttctctgc atagaaacaa gccactatgt   3000

tgcttttgtg aagtatggga aggacgattc tgcctggctc ttctttgaca gcatggccga   3060

tcgggatggt ggtcagaatg gcttcaacat tcctcaagtc accccatgcc cagaagtagg   3120

agagtacttg aagatgtctc tggaagacct gcattccttg gactccagga gaatccaagg   3180

ctgtgcacga agactgcttt gtgatgcata tatgtgcatg taccagagtc caacaatgag   3240

tttgtacaaa taactggggt catcgggaaa ggcaaagaaa ctgaaggcag agtcctaacg   3300

ttgcatctta ttcgagctgg cagttctgtt cacgtccatt gccggcaatg gatgtctttg   3360

tggtgatgat ccttcagaaa aggatgcctc tgtttaaaaa caaattgctt ttgtgtccct   3420

gaagtattta ataagaagca ttttgcactc tagaaagtat gtttgtgttg gttttttaag   3480

aagtctaaat gaagttatta atacctgaag ctttaagtta agtgcattga tcatatgata   3540

tttttggaag catacaattt taattgtgga agtttaaagc ctcttttagt ccattgagaa   3600

tgtaaataaa tgtgtcttct ttatggacca aggatatgaa atcatttttc ttttgtagct   3660

aacggttgcc ttgaggaaga aataatttgg ttttattaag agtctactct caatccagtt   3720

attagagatg tactgagttt gatttgttaa tcctttctat atactgctga tcttgcatgt   3780

ctacaatctg ctcagttttt ctgtgtttct gcaatagtgg tcagaaaaat acttaaattc   3840

ccttaatggt gttgttttct atttgttctg gttttgagat aaatgagtga ttctgtcccc   3900

aaatgtccat ttttgaagtg attttcctgg aggattaggg tatttagcag ttgaagctct   3960

tcattcatag tagttactgt cagctaacag gttttttaag gcttttaact attaatattt   4020

tatggaatgg ggcaaagtaa attgatgaaa gaattggagt gataatagtc ctttacaaac   4080

atacagtcca taagaaaatg aatttggcat atagaattat tacaatttcc tgggagagat   4140

ggatatttaa acctctatta ttttagacaa gactgtctag aacttaagtt tgatctgtca   4200

gccagtactc ccattaaatt cagtgtagtt tcacttgata gaatcagata tgttatcgaa   4260

atgttagcag cagcttcatc ctccttctga ttaaagtaag tagaaatggg atgttttgtt   4320

taataacagc catagtgtgt gtttagacca cagcggatgt tgtagaccag gaccatagat   4380

gatacatgtc agtgctgtgg aatgtgcatt ctctgagtgt tgttttgtgg tatcattgtc   4440

tttcctgaat gactttctaa ctgtgcagaa aggcagaaaa gtcatcatat gtatatgtca   4500

tatgacttta taaaatattt aatgtgacaa aaagtggaaa gaatctttac aaaccctgca   4560

attacttttt taaaggcact tttactcttt ggttttatca ttccattttg ctaatattta   4620

ctagctttat aaattacagt aaggtacaaa aactcatctt gtaatatttt catttttgaa   4680

gtgaaaaagt acatatattt tgcacaaggt tttatactgc taagtgcttg gttggggtgg   4740

tgagatgatg attagatcag gggtgaggct gagagactct gggtttaggg ctagccctgc   4800

ctccatctcc cttgggtaaa atgaagggtg tggggtaaaa gatgcataag gccttttcta   4860

gctctgacag cctagaagtc caatcaccct gtaataaata tgtgttgaat gaagaaatgg   4920

gtgaatgagc ttgtcaatgt gattttaaaa aattgactac ctggaggaat gattaggaat   4980

ctaaatgaag ccagccctcg gtatctgcag gtttctcatc catggattca accaactgca   5040

aatggaaaat acgatttttt ttaaaaaaag gatggttaca tccgtattga acatgtacag   5100

acttttttct tgtcattatt ctctgaacaa tacaagaact ctttatgtag catttacatt   5160

tattaggtat tataagtaat ctagagatta tttaattaaa atatacagga ggatgtgtgt   5220

cagttatatg caaattctgt accattttgt atcagggaat tgagcatctt cagatgttgg   5280

tatctgcagg gatcctggaa ccaaacccct gcagatacta agggctgacg atctaggtaa   5340

gactggattt aacagttgga aaaaaaaaaa aaaaaggaga gagaagacag ttcctttcct   5400

gtagaaatta aaacaaaata caaattgagg aagctctgct acccaggctg tcatggtaga   5460

gaacttgaag aagacctgtt tggatggaca cctggtttca aaagtcaggt gtggagactg   5520

ttaaatggga gggcctcatc cataaatgat ttctggcaac gtcttcttca ggtggagctt   5580

gacgtctttt taatgttact tggggaggga gtgctcatta agggatgcca gggccagctc   5640

tggtggttcc tggggaggct gcgtccttcc ctgcttctgc atgtcatgag gcagcaggaa   5700

ggtttcccct gcacctgtct gtcctggctc cctctgggta gccccctact gttctgtgct   5760

tcagcacagc ctggtttgtc aagaggcaca tagttggggc tgggctgcat ggcacagggg   5820

cttatgtgcc tgctggttat ttaattttca gccttaagtt ttctttaata ttttcctgtt   5880

ggctatttaa aggttttggt tatcttttat tccttatcta caatcaagat gacaatgtaa   5940

ttgaattatc ttatttataa cacggttcgt gattcatgat tcatgattac aagtagaaaa   6000

tatgtcatgt tcctcacctc caaataaata tgtgtgtgtc tgtgtgtgtg tatatatgta   6060

tgtggcggag agggagagag tggggaagga gagcagtgtt atcatacata gagaggctaa   6120

atgtgtccca tccctcactg tcagctttat aaaggagttt gactccatcc acagaagaat   6180

gttttataag actaggaaaa cacgttgaaa actaggataa acagcaacaa aaatcaacta   6240

aatatgttgt tactgttgct aaggattttc tccttagaat aatttaggat ttttaaaaat   6300

ttctgtttgc caaatgctgt agataaatgg ccagattctt cctatcccta ggattccttt   6360

attatttttt ttcacagatt ttgagaacaa gggggagaga tagtatggaa gattaagatt   6420

ccattaatct tatagaactg tgttgtcacc caaattcctg cttgtttgaa catggcatct   6480

tcatagattc aggattcact accctctata gctggatctt gaaaattatc tggccagata   6540

attttgcatc tgcttggatg attgtagact gagatgtgag tggaggataa agtattagac   6600

ttttgctgag taactgccaa ccaagaagta tttatcggac acttactagg tgcctaggat   6660

tgtatcagag ggaatatgaa atgtgtccct gccctaccta gttttaacga cagaatatct   6720

attaaaggct acttagctga agggtaaggg tgacaggtct aggggaagct ttgggaggtg   6780

gtgtgctgtg acagaaaaag tggcagagta gggacgagag acctgcattc tagccctgtt   6840

tctgtcactt gctctgtaca cttagacaac agcttgacct cttgagcttt agtttcctcc   6900

tctgcataat gagagggtta gactactgaa ttgtatggga aaaaaataca aattcctggg   6960

tcctaggcca tgcctgctga atccgactgt tcaggaagag gcctaggaaa tctgtgaggg   7020

aatccccagg ggaatctcgt gaccagccag gtgtgaaatc tgctaactgg aagatctcaa   7080

agcttccttc actttttgtg attttgtggt catgtaacgt tactgtatta ttctacgtaa   7140

atgtgggtac ttggatgttt atcatactgt ttctctgtgt ttacatacta atttgtgtaa   7200

gaaatgcatt ttagtctgtg tacctcaacc tgctgtttgt ttcctagagg tgttagtagt   7260

ctttaaatac aagtaagact taagaggata tttgatgtta tttacctgga tattttcttc   7320

cccttttatt tatttagagg aaattgagat tctaggagcc aaaaaaatga aaacaaaatt   7380

ctaaggcaaa gttaaagaaa aaaattacat tatttcttac catttgctac tttataatga   7440

aaatttaaaa attatatggg aagatttttc tctgggataa caaatccttg tcataaagta   7500

agaggtcttt ttaaagtagg taggctataa ggcctgtaat ttaaaataat actcctttct   7560

ctagggtttg gtgcaattct ccattaatga agataacatt tgaattcccc aaagcaggtg   7620

aggagtcggg gaggagaaag cgatgttaaa atgaaaactc actgcaaaag aggaggcaga   7680

ggaagaagga atgtaaaccc cttaaagcag atgtgtgtgg ggccttatga agaccaggat   7740

tctgcgggtg tcaggggatt gcccctcttg acagagacta gggttttaga ctgaggcttc   7800

ctgcagggtg ttcgcattgc ccttctccgt tccccttcag acctttctgg ggagaagagg   7860

tgggaggagg ggagaaagac tgttcatctt attctgaatc ctggagcagc tgaaggtttt   7920

ctcttgagtc aggatgcagt ggtaatgcat taaccagcaa gtgtggccaa ggataatgaa   7980

aaagtgggaa aggaaggtcc tcctcctccc tgattgtagc atccagcagt ctctgtagcc   8040

aggttactca agaaccacat ttgatttcct ggccctttgc cttggcagtg atggcatttt   8100

tatttcactg tgttttaaag tcttcattta tttttataac atgggttagg gagaagggcc   8160

acaaatggag ggattgtcct ttcaagcacc acagcttcag ataaaattag tactttcaaa   8220

tattgtccac tttaacttaa aaaattctag agggattata ttggagactc aactgccctt   8280

ggttttagtt tataaaatgg cctagtactg tggaatttta attttagaaa gtcttagcat   8340

cagatcataa acattcatta aaagaactca catcccatct gaaacttccc aggggagttg   8400

ggattcttag tagattggta gaaaggggct cattttctac tgcatttccc atttttggta   8460

tcttgttcag catgttttat ttttatttct tgtctgcaga acatcctata tttatgagaa   8520

cattctttaa gaagaccacc acatagaata ccccttccta tcagctcgct ctgatttagc   8580

cttaattttg ttaaattttt tagagatgaa tgaagtgctg ctgtggaaag aaatgtacat   8640

atactatttc tgtatcatta aaattacatt tttatggttc ct                      8682


<210>  3280
<211>  953
<212>  PRT
<213>  Homo sapiens

<400>  3280


Met Ser Ser Gly Leu Trp Ser Gln Glu Lys Val Thr Ser Pro Tyr Trp 
1               5                   10                  15      


Glu Glu Arg Ile Phe Tyr Leu Leu Leu Gln Glu Cys Ser Val Thr Asp 
            20                  25                  30          


Lys Gln Thr Gln Lys Leu Leu Lys Val Pro Lys Gly Ser Ile Gly Gln 
        35                  40                  45              


Tyr Ile Gln Asp Arg Ser Val Gly His Ser Arg Ile Pro Ser Ala Lys 
    50                  55                  60                  


Gly Lys Lys Asn Gln Ile Gly Leu Lys Ile Leu Glu Gln Pro His Ala 
65                  70                  75                  80  


Val Leu Phe Val Asp Glu Lys Asp Val Val Glu Ile Asn Glu Lys Phe 
                85                  90                  95      


Thr Glu Leu Leu Leu Ala Ile Thr Asn Cys Glu Glu Arg Phe Ser Leu 
            100                 105                 110         


Phe Lys Asn Arg Asn Arg Leu Ser Lys Gly Leu Gln Ile Asp Val Gly 
        115                 120                 125             


Cys Pro Val Lys Val Gln Leu Arg Ser Gly Glu Glu Lys Phe Pro Gly 
    130                 135                 140                 


Val Val Arg Phe Arg Gly Pro Leu Leu Ala Glu Arg Thr Val Ser Gly 
145                 150                 155                 160 


Ile Phe Phe Gly Val Glu Leu Leu Glu Glu Gly Arg Gly Gln Gly Phe 
                165                 170                 175     


Thr Asp Gly Val Tyr Gln Gly Lys Gln Leu Phe Gln Cys Asp Glu Asp 
            180                 185                 190         


Cys Gly Val Phe Val Ala Leu Asp Lys Leu Glu Leu Ile Glu Asp Asp 
        195                 200                 205             


Asp Thr Ala Leu Glu Ser Asp Tyr Ala Gly Pro Gly Asp Thr Met Gln 
    210                 215                 220                 


Val Glu Leu Pro Pro Leu Glu Ile Asn Ser Arg Val Ser Leu Lys Val 
225                 230                 235                 240 


Gly Glu Thr Ile Glu Ser Gly Thr Val Ile Phe Cys Asp Val Leu Pro 
                245                 250                 255     


Gly Lys Glu Ser Leu Gly Tyr Phe Val Gly Val Asp Met Asp Asn Pro 
            260                 265                 270         


Ile Gly Asn Trp Asp Gly Arg Phe Asp Gly Val Gln Leu Cys Ser Phe 
        275                 280                 285             


Ala Cys Val Glu Ser Thr Ile Leu Leu His Ile Asn Asp Ile Ile Pro 
    290                 295                 300                 


Glu Ser Val Thr Gln Glu Arg Arg Pro Pro Lys Leu Ala Phe Met Ser 
305                 310                 315                 320 


Arg Gly Val Gly Asp Lys Gly Ser Ser Ser His Asn Lys Pro Lys Ala 
                325                 330                 335     


Thr Gly Ser Thr Ser Asp Pro Gly Asn Arg Asn Arg Ser Glu Leu Phe 
            340                 345                 350         


Tyr Thr Leu Asn Gly Ser Ser Val Asp Ser Gln Pro Gln Ser Lys Ser 
        355                 360                 365             


Lys Asn Thr Trp Tyr Ile Asp Glu Val Ala Glu Asp Pro Ala Lys Ser 
    370                 375                 380                 


Leu Thr Glu Ile Ser Thr Asp Phe Asp Arg Ser Ser Pro Pro Leu Gln 
385                 390                 395                 400 


Pro Pro Pro Val Asn Ser Leu Thr Thr Glu Asn Arg Phe His Ser Leu 
                405                 410                 415     


Pro Phe Ser Leu Thr Lys Met Pro Asn Thr Asn Gly Ser Ile Gly His 
            420                 425                 430         


Ser Pro Leu Ser Leu Ser Ala Gln Ser Val Met Glu Glu Leu Asn Thr 
        435                 440                 445             


Ala Pro Val Gln Glu Ser Pro Pro Leu Ala Met Pro Pro Gly Asn Ser 
    450                 455                 460                 


His Gly Leu Glu Val Gly Ser Leu Ala Glu Val Lys Glu Asn Pro Pro 
465                 470                 475                 480 


Phe Tyr Gly Val Ile Arg Trp Ile Gly Gln Pro Pro Gly Leu Asn Glu 
                485                 490                 495     


Val Leu Ala Gly Leu Glu Leu Glu Asp Glu Cys Ala Gly Cys Thr Asp 
            500                 505                 510         


Gly Thr Phe Arg Gly Thr Arg Tyr Phe Thr Cys Ala Leu Lys Lys Ala 
        515                 520                 525             


Leu Phe Val Lys Leu Lys Ser Cys Arg Pro Asp Ser Arg Phe Ala Ser 
    530                 535                 540                 


Leu Gln Pro Val Ser Asn Gln Ile Glu Arg Cys Asn Ser Leu Ala Phe 
545                 550                 555                 560 


Gly Gly Tyr Leu Ser Glu Val Val Glu Glu Asn Thr Pro Pro Lys Met 
                565                 570                 575     


Glu Lys Glu Gly Leu Glu Ile Met Ile Gly Lys Lys Lys Gly Ile Gln 
            580                 585                 590         


Gly His Tyr Asn Ser Cys Tyr Leu Asp Ser Thr Leu Phe Cys Leu Phe 
        595                 600                 605             


Ala Phe Ser Ser Val Leu Asp Thr Val Leu Leu Arg Pro Lys Glu Lys 
    610                 615                 620                 


Asn Asp Val Glu Tyr Tyr Ser Glu Thr Gln Glu Leu Leu Arg Thr Glu 
625                 630                 635                 640 


Ile Val Asn Pro Leu Arg Ile Tyr Gly Tyr Val Cys Ala Thr Lys Ile 
                645                 650                 655     


Met Lys Leu Arg Lys Ile Leu Glu Lys Val Glu Ala Ala Ser Gly Phe 
            660                 665                 670         


Thr Ser Glu Glu Lys Asp Pro Glu Glu Phe Leu Asn Ile Leu Phe His 
        675                 680                 685             


His Ile Leu Arg Val Glu Pro Leu Leu Lys Ile Arg Ser Ala Gly Gln 
    690                 695                 700                 


Lys Val Gln Asp Cys Tyr Phe Tyr Gln Ile Phe Met Glu Lys Asn Glu 
705                 710                 715                 720 


Lys Val Gly Val Pro Thr Ile Gln Gln Leu Leu Glu Trp Ser Phe Ile 
                725                 730                 735     


Asn Ser Asn Leu Lys Phe Ala Glu Ala Pro Ser Cys Leu Ile Ile Gln 
            740                 745                 750         


Met Pro Arg Phe Gly Lys Asp Phe Lys Leu Phe Lys Lys Ile Phe Pro 
        755                 760                 765             


Ser Leu Glu Leu Asn Ile Thr Asp Leu Leu Glu Asp Thr Pro Arg Gln 
    770                 775                 780                 


Cys Arg Ile Cys Gly Gly Leu Ala Met Tyr Glu Cys Arg Glu Cys Tyr 
785                 790                 795                 800 


Asp Asp Pro Asp Ile Ser Ala Gly Lys Ile Lys Gln Phe Cys Lys Thr 
                805                 810                 815     


Cys Asn Thr Gln Val His Leu His Pro Lys Arg Leu Asn His Lys Tyr 
            820                 825                 830         


Asn Pro Val Ser Leu Pro Lys Asp Leu Pro Asp Trp Asp Trp Arg His 
        835                 840                 845             


Gly Cys Ile Pro Cys Gln Asn Met Glu Leu Phe Ala Val Leu Cys Ile 
    850                 855                 860                 


Glu Thr Ser His Tyr Val Ala Phe Val Lys Tyr Gly Lys Asp Asp Ser 
865                 870                 875                 880 


Ala Trp Leu Phe Phe Asp Ser Met Ala Asp Arg Asp Gly Gly Gln Asn 
                885                 890                 895     


Gly Phe Asn Ile Pro Gln Val Thr Pro Cys Pro Glu Val Gly Glu Tyr 
            900                 905                 910         


Leu Lys Met Ser Leu Glu Asp Leu His Ser Leu Asp Ser Arg Arg Ile 
        915                 920                 925             


Gln Gly Cys Ala Arg Arg Leu Leu Cys Asp Ala Tyr Met Cys Met Tyr 
    930                 935                 940                 


Gln Ser Pro Thr Met Ser Leu Tyr Lys 
945                 950             

<210>  3281
<211>  3535
<212>  DNA
<213>  Homo sapiens

<400>  3281
aaatactagg gcggtgggtg tggggagccg gggccggccc gggacgcggg ctggggagcc     60

ggggcgaggg gcgacgcccc gccgcccgag tttccccctt tctagggtga ggatggttct    120

acacagccac ccggagttcc ttagttgaaa ggtgcgccct gctgtgacag catggacacc    180

acgttgctga aaacatgctt tgggactgcc actgaattta tcttttgcgg ttttatgaca    240

aagttattag tagtttccct tttttgaatt agtattttga agttaatatc acaatgagtt    300

caggcttatg gagccaagaa aaagtcactt caccctactg ggaagagcgg attttttact    360

tgcttcttca agaatgcagc gttacagaca aacaaacaca aaagctcctt aaagtaccga    420

agggaagtat aggacagtat attcaagatc gttctgtggg gcattcaagg attccttctg    480

caaaaggcaa gaaaaatcag attggattaa aaattctaga gcaacctcat gcagttctct    540

ttgttgatga aaaggatgtt gtagagataa atgaaaagtt cacagagtta cttttggcaa    600

ttaccaattg tgaggagagg ttcagcctgt ttaaaaacag aaacagacta agtaaaggcc    660

tccaaataga cgtgggctgt cctgtgaaag tacagctgag atctggggaa gaaaaatttc    720

ctggagttgt acgcttcaga ggacccctgt tagcagagag gacagtctcc ggaatattct    780

ttggagttga attgctggaa gaaggtcgtg gtcaaggttt cactgacggg gtgtaccaag    840

ggaaacagct ttttcagtgt gatgaagatt gtggcgtgtt tgttgcattg gacaagctag    900

aactcataga agatgatgac actgcattgg aaagtgatta cgcaggtcct ggggacacaa    960

tgcaggtcga acttcctcct ttggaaataa actccagagt ttctttgaag gttggagaaa   1020

caatagaatc tggaacagtt atattctgtg atgttttgcc aggaaaagaa agcttaggat   1080

attttgttgg tgtggacatg gataacccta ttggcaactg ggatggaaga tttgatggag   1140

tgcagctttg tagttttgcg tgtgttgaaa gtacaattct attgcacatc aatgatatca   1200

tcccagagag tgtgacgcag gaaaggaggc ctcccaaact tgcctttatg tcaagaggtg   1260

ttggggacaa aggttcatcc agtcataata aaccaaaggc tacaggatct acctcagacc   1320

ctggaaatag aaacagatct gaattatttt ataccttaaa tgggtcttct gttgactcac   1380

aaccacaatc caaatcaaaa aatacatggt acattgatga agttgcagaa gaccctgcaa   1440

aatctcttac agagatatct acagactttg accgttcttc accaccactc cagcctcctc   1500

ctgtgaactc actgaccacc gagaacagat tccactcttt accattcagt ctcaccaaga   1560

tgcccaatac caatggaagt attggccaca gtccactttc tctgtcagcc cagtctgtaa   1620

tggaagagct aaacactgca cccgtccaag agagtccacc cttggccatg cctcctggga   1680

actcacatgg tctagaagtg ggctcattgg ctgaagttaa ggagaaccct cctttctatg   1740

gggtaatccg ttggatcggt cagccaccag gactgaatga agtgctcgct ggactggaac   1800

tggaagatga gtgtgcaggc tgtacggatg gaaccttcag aggcactcgg tatttcacct   1860

gtgccctgaa gaaggcgctg tttgtgaaac tgaagagctg caggcctgac tctaggtttg   1920

catcattgca gccggtttcc aatcagattg agcgctgtaa ctctttagca tttggaggct   1980

acttaagtga agtagtagaa gaaaatactc caccaaaaat ggaaaaagaa ggcttggaga   2040

taatgattgg gaagaagaaa ggcatccagg gtcattacaa ttcttgttac ttagactcaa   2100

ccttattctg cttatttgct tttagttctg ttctggacac tgtgttactt agacccaaag   2160

aaaagaacga tgtagaatat tatagtgaaa cccaagagct actgaggaca gaaattgtta   2220

atcctctgag aatatatgga tatgtgtgtg ccacaaaaat tatgaaactg aggaaaatac   2280

ttgaaaaggt ggaggctgca tcaggattta cctctgaaga aaaagatcct gaggaattct   2340

tgaatattct gtttcatcat attttaaggg tagaaccttt gctaaaaata agatcagcag   2400

gtcaaaaggt acaagattgt tacttctatc aaatttttat ggaaaaaaat gagaaagttg   2460

gcgttcccac aattcagcag ttgttagaat ggtcttttat caacagtaac ctgaaatttg   2520

cagaggcacc atcatgtctg attattcaga tgcctcgatt tggaaaagac tttaaactat   2580

ttaaaaaaat ttttccttct ctggaattaa atataacaga tttacttgaa gacactccca   2640

gacagtgccg gatatgtgga gggcttgcaa tgtatgagtg tagagaatgc tacgacgatc   2700

cggacatctc agctggaaaa atcaagcagt tttgtaaaac ctgcaacact caagtccacc   2760

ttcatccgaa gaggctgaat cataaatata acccagtgtc acttcccaaa gacttacccg   2820

actgggactg gagacacggc tgcatccctt gccagaatat ggagttattt gctgttctct   2880

gcatagaaac aagccactat gttgcttttg tgaagtatgg gaaggacgat tctgcctggc   2940

tcttctttga cagcatggcc gatcgggatg gtggtcagaa tggcttcaac attcctcaag   3000

tcaccccatg cccagaagta ggagagtact tgaagatgtc tctggaagac ctgcattcct   3060

tggactccag gagaatccaa ggctgtgcac gaagactgct ttgtgatgca tatatgtgca   3120

tgtaccagag tccaacaatg agtttgtaca aataactggg gtcatcggga aaggcaaaga   3180

aactgaaggc agagtcctaa cgttgcatct tattcgagct ggcagttctg ttcacgtcca   3240

ttgccggcaa tggatgtctt tgtggtgatg atccttcaga aaaggatgcc tctgtttaaa   3300

aacaaattgc ttttgtgtcc ctgaagtatt taataagaag cattttgcac tctagaaagt   3360

atgtttgtgt tggtttttta agaagtctaa atgaagttat taatacctga agctttaagt   3420

taagtgcatt gatcatatga tatttttgga agcatacaat tttaattgtg gaagtttaaa   3480

gcctctttta gtccattgag aatgtaaata aatgtgtctt ctttatggac caagg        3535


<210>  3282
<211>  953
<212>  PRT
<213>  Homo sapiens

<400>  3282


Met Ser Ser Gly Leu Trp Ser Gln Glu Lys Val Thr Ser Pro Tyr Trp 
1               5                   10                  15      


Glu Glu Arg Ile Phe Tyr Leu Leu Leu Gln Glu Cys Ser Val Thr Asp 
            20                  25                  30          


Lys Gln Thr Gln Lys Leu Leu Lys Val Pro Lys Gly Ser Ile Gly Gln 
        35                  40                  45              


Tyr Ile Gln Asp Arg Ser Val Gly His Ser Arg Ile Pro Ser Ala Lys 
    50                  55                  60                  


Gly Lys Lys Asn Gln Ile Gly Leu Lys Ile Leu Glu Gln Pro His Ala 
65                  70                  75                  80  


Val Leu Phe Val Asp Glu Lys Asp Val Val Glu Ile Asn Glu Lys Phe 
                85                  90                  95      


Thr Glu Leu Leu Leu Ala Ile Thr Asn Cys Glu Glu Arg Phe Ser Leu 
            100                 105                 110         


Phe Lys Asn Arg Asn Arg Leu Ser Lys Gly Leu Gln Ile Asp Val Gly 
        115                 120                 125             


Cys Pro Val Lys Val Gln Leu Arg Ser Gly Glu Glu Lys Phe Pro Gly 
    130                 135                 140                 


Val Val Arg Phe Arg Gly Pro Leu Leu Ala Glu Arg Thr Val Ser Gly 
145                 150                 155                 160 


Ile Phe Phe Gly Val Glu Leu Leu Glu Glu Gly Arg Gly Gln Gly Phe 
                165                 170                 175     


Thr Asp Gly Val Tyr Gln Gly Lys Gln Leu Phe Gln Cys Asp Glu Asp 
            180                 185                 190         


Cys Gly Val Phe Val Ala Leu Asp Lys Leu Glu Leu Ile Glu Asp Asp 
        195                 200                 205             


Asp Thr Ala Leu Glu Ser Asp Tyr Ala Gly Pro Gly Asp Thr Met Gln 
    210                 215                 220                 


Val Glu Leu Pro Pro Leu Glu Ile Asn Ser Arg Val Ser Leu Lys Val 
225                 230                 235                 240 


Gly Glu Thr Ile Glu Ser Gly Thr Val Ile Phe Cys Asp Val Leu Pro 
                245                 250                 255     


Gly Lys Glu Ser Leu Gly Tyr Phe Val Gly Val Asp Met Asp Asn Pro 
            260                 265                 270         


Ile Gly Asn Trp Asp Gly Arg Phe Asp Gly Val Gln Leu Cys Ser Phe 
        275                 280                 285             


Ala Cys Val Glu Ser Thr Ile Leu Leu His Ile Asn Asp Ile Ile Pro 
    290                 295                 300                 


Glu Ser Val Thr Gln Glu Arg Arg Pro Pro Lys Leu Ala Phe Met Ser 
305                 310                 315                 320 


Arg Gly Val Gly Asp Lys Gly Ser Ser Ser His Asn Lys Pro Lys Ala 
                325                 330                 335     


Thr Gly Ser Thr Ser Asp Pro Gly Asn Arg Asn Arg Ser Glu Leu Phe 
            340                 345                 350         


Tyr Thr Leu Asn Gly Ser Ser Val Asp Ser Gln Pro Gln Ser Lys Ser 
        355                 360                 365             


Lys Asn Thr Trp Tyr Ile Asp Glu Val Ala Glu Asp Pro Ala Lys Ser 
    370                 375                 380                 


Leu Thr Glu Ile Ser Thr Asp Phe Asp Arg Ser Ser Pro Pro Leu Gln 
385                 390                 395                 400 


Pro Pro Pro Val Asn Ser Leu Thr Thr Glu Asn Arg Phe His Ser Leu 
                405                 410                 415     


Pro Phe Ser Leu Thr Lys Met Pro Asn Thr Asn Gly Ser Ile Gly His 
            420                 425                 430         


Ser Pro Leu Ser Leu Ser Ala Gln Ser Val Met Glu Glu Leu Asn Thr 
        435                 440                 445             


Ala Pro Val Gln Glu Ser Pro Pro Leu Ala Met Pro Pro Gly Asn Ser 
    450                 455                 460                 


His Gly Leu Glu Val Gly Ser Leu Ala Glu Val Lys Glu Asn Pro Pro 
465                 470                 475                 480 


Phe Tyr Gly Val Ile Arg Trp Ile Gly Gln Pro Pro Gly Leu Asn Glu 
                485                 490                 495     


Val Leu Ala Gly Leu Glu Leu Glu Asp Glu Cys Ala Gly Cys Thr Asp 
            500                 505                 510         


Gly Thr Phe Arg Gly Thr Arg Tyr Phe Thr Cys Ala Leu Lys Lys Ala 
        515                 520                 525             


Leu Phe Val Lys Leu Lys Ser Cys Arg Pro Asp Ser Arg Phe Ala Ser 
    530                 535                 540                 


Leu Gln Pro Val Ser Asn Gln Ile Glu Arg Cys Asn Ser Leu Ala Phe 
545                 550                 555                 560 


Gly Gly Tyr Leu Ser Glu Val Val Glu Glu Asn Thr Pro Pro Lys Met 
                565                 570                 575     


Glu Lys Glu Gly Leu Glu Ile Met Ile Gly Lys Lys Lys Gly Ile Gln 
            580                 585                 590         


Gly His Tyr Asn Ser Cys Tyr Leu Asp Ser Thr Leu Phe Cys Leu Phe 
        595                 600                 605             


Ala Phe Ser Ser Val Leu Asp Thr Val Leu Leu Arg Pro Lys Glu Lys 
    610                 615                 620                 


Asn Asp Val Glu Tyr Tyr Ser Glu Thr Gln Glu Leu Leu Arg Thr Glu 
625                 630                 635                 640 


Ile Val Asn Pro Leu Arg Ile Tyr Gly Tyr Val Cys Ala Thr Lys Ile 
                645                 650                 655     


Met Lys Leu Arg Lys Ile Leu Glu Lys Val Glu Ala Ala Ser Gly Phe 
            660                 665                 670         


Thr Ser Glu Glu Lys Asp Pro Glu Glu Phe Leu Asn Ile Leu Phe His 
        675                 680                 685             


His Ile Leu Arg Val Glu Pro Leu Leu Lys Ile Arg Ser Ala Gly Gln 
    690                 695                 700                 


Lys Val Gln Asp Cys Tyr Phe Tyr Gln Ile Phe Met Glu Lys Asn Glu 
705                 710                 715                 720 


Lys Val Gly Val Pro Thr Ile Gln Gln Leu Leu Glu Trp Ser Phe Ile 
                725                 730                 735     


Asn Ser Asn Leu Lys Phe Ala Glu Ala Pro Ser Cys Leu Ile Ile Gln 
            740                 745                 750         


Met Pro Arg Phe Gly Lys Asp Phe Lys Leu Phe Lys Lys Ile Phe Pro 
        755                 760                 765             


Ser Leu Glu Leu Asn Ile Thr Asp Leu Leu Glu Asp Thr Pro Arg Gln 
    770                 775                 780                 


Cys Arg Ile Cys Gly Gly Leu Ala Met Tyr Glu Cys Arg Glu Cys Tyr 
785                 790                 795                 800 


Asp Asp Pro Asp Ile Ser Ala Gly Lys Ile Lys Gln Phe Cys Lys Thr 
                805                 810                 815     


Cys Asn Thr Gln Val His Leu His Pro Lys Arg Leu Asn His Lys Tyr 
            820                 825                 830         


Asn Pro Val Ser Leu Pro Lys Asp Leu Pro Asp Trp Asp Trp Arg His 
        835                 840                 845             


Gly Cys Ile Pro Cys Gln Asn Met Glu Leu Phe Ala Val Leu Cys Ile 
    850                 855                 860                 


Glu Thr Ser His Tyr Val Ala Phe Val Lys Tyr Gly Lys Asp Asp Ser 
865                 870                 875                 880 


Ala Trp Leu Phe Phe Asp Ser Met Ala Asp Arg Asp Gly Gly Gln Asn 
                885                 890                 895     


Gly Phe Asn Ile Pro Gln Val Thr Pro Cys Pro Glu Val Gly Glu Tyr 
            900                 905                 910         


Leu Lys Met Ser Leu Glu Asp Leu His Ser Leu Asp Ser Arg Arg Ile 
        915                 920                 925             


Gln Gly Cys Ala Arg Arg Leu Leu Cys Asp Ala Tyr Met Cys Met Tyr 
    930                 935                 940                 


Gln Ser Pro Thr Met Ser Leu Tyr Lys 
945                 950             

<210>  3283
<211>  357
<212>  DNA
<213>  Homo sapiens

<400>  3283
catttagatt cctaatcatt cctccaggta ccaggacccc tgtgaagata cccatggttc     60

aatcatcagg acctacagat ccttccatgt taaggacaac accaataata ctgagaaagc    120

aaacggcaga ttggcagtgt taaaggataa caacgtgcca acagaatatt aagaaagaaa    180

acttctttgc aaaagttgat agagagacta caaatatcag tcaaattaca aacagacaac    240

agaggacagc atttggaaac gacttcccga ggcaagcact attcagtgcc ccacttccct    300

ctccccatgc ccctttgcaa agatctatta cattaataaa tttctttaaa tgctaaa       357


<210>  3284
<211>  54
<212>  PRT
<213>  Homo sapiens

<400>  3284


Ile Pro Asn His Ser Ser Arg Tyr Gln Asp Pro Cys Glu Asp Thr His 
1               5                   10                  15      


Gly Ser Ile Ile Arg Thr Tyr Arg Ser Phe His Val Lys Asp Asn Thr 
            20                  25                  30          


Asn Asn Thr Glu Lys Ala Asn Gly Arg Leu Ala Val Leu Lys Asp Asn 
        35                  40                  45              


Asn Val Pro Thr Glu Tyr 
    50                  

<210>  3285
<211>  786
<212>  DNA
<213>  Homo sapiens

<400>  3285
cataaggagc tttgacaagg acccactgtc tggccccatc ttcagagatt ccaataggtc     60

tggggtgtgc acaggcactg gcgtctttaa aatctccctg tgtgaattca acatgcaacc    120

aggattgaat ggagaactgc tgctcgaagt ttgataatga ggtgataatg aggaagaaca    180

tgcctcagca agtcagaaaa aggggcttag gggagggcca gtggctcctc cttcggccag    240

gccagctttc ttctgacaag gacttgtttt cacaactgtc cagatccgca gatgggcaca    300

agatgatgga atgaagcagc gggggacaac ttctggctgg agtggcttgg aggctggagc    360

agctgagctt taacaagcat cagaggtcag aattacttgg ctagatcaag aagccacaca    420

gcatcataat gccgctggca catctcccag aacagggtac caggacccct gtgaagatac    480

ccatggttca atcatcagga cctacagatc cttccatgtt aaggacaaca ccaataatac    540

tgagaaagca aacggcagat tggcagtgtt aaaggataac aacgtgccaa cagaatatta    600

agaaagaaaa cttctttgca aaagttgata gagagactac aaatatcagt caaattacaa    660

acagacaaca gaggacagca tttggaaacg acttcccgag gcaagcacta ttcagtgccc    720

cacttccctc tccccatgcc cctttgcaaa gatctattac attaataaat ttctttaaat    780

gctaaa                                                               786


<210>  3286
<211>  61
<212>  PRT
<213>  Homo sapiens

<400>  3286


Met Glu Asn Cys Cys Ser Lys Phe Asp Asn Glu Val Ile Met Arg Lys 
1               5                   10                  15      


Asn Met Pro Gln Gln Val Arg Lys Arg Gly Leu Gly Glu Gly Gln Trp 
            20                  25                  30          


Leu Leu Leu Arg Pro Gly Gln Leu Ser Ser Asp Lys Asp Leu Phe Ser 
        35                  40                  45              


Gln Leu Ser Arg Ser Ala Asp Gly His Lys Met Met Glu 
    50                  55                  60      

<210>  3287
<211>  1141
<212>  DNA
<213>  Homo sapiens

<400>  3287
ggattgtatc agagggaata tgaaatgtgt ccctgcccta cctagtttta acgacagaat     60

atctattaaa ggctacttag ctgaagggta agggtgacag gtctagggga agctttggga    120

ggtggtgtgc tgtgacagaa aaagtggcag agtagggacg agagacctgc attctagccc    180

tgtttctgtc acttgctctg tacacttaga caacagcttg acctcttgag ctttagtttc    240

ctcctctgca taatgagagg gttagactac tgaattgtat gggaaaaaaa tacaaattcc    300

tgggtcctag gccatgcctg ctgaatccga ctgttcagga agaggcctag gaaatctgtg    360

agggaatccc caggggaatc tcgtgaccag ccaggtgtga aatctgctaa ctggaagatc    420

tcaaagcttc cttcactttt tgtgattttg tggtcatgta acgttactgt attattctac    480

gtaaatgtgg gtacttggat gtttatcata ctgtttctct gtgtttacat actaatttgt    540

gtaagaaatg cattttagtc tgtgtacctc aacctgctgt ttgtttccta gaggtgttag    600

tagtctttaa atacaagtaa gacttaagag gatatttgat gttatttacc tggatatttt    660

cttccccttt tatttattta gaggaaattg agattctagg agccaaaaaa atgaaaacaa    720

aattctaagg caaagttaaa gaaaaaaatt acattatttc ttaccatttg ctactttata    780

atgaaaattt aaaaattata tgggaagatt tttctctggg ataacaaatc cttgtcataa    840

agtaagaggt ctttttaaag taggtaggct ataaggcctg taatttaaaa taatactcct    900

ttctctaggg tttggtgcaa ttctccatta atgaagataa catttgaatt ccccaaagca    960

gaacatccta tatttatgag aacattcttt aagaagacca ccacatagaa taccccttcc   1020

tatcagctcg ctctgattta gccttaattt tgttaaattt tttagagatg aatgaagtgc   1080

tgctgtggaa agaaatgtac atatactatt tctgtatcat taaaattaca tttttatggt   1140

t                                                                   1141


<210>  3288
<211>  52
<212>  PRT
<213>  Homo sapiens

<400>  3288


Arg Tyr Cys Ile Ile Leu Arg Lys Cys Gly Tyr Leu Asp Val Tyr His 
1               5                   10                  15      


Thr Val Ser Leu Cys Leu His Thr Asn Leu Cys Lys Lys Cys Ile Leu 
            20                  25                  30          


Val Cys Val Pro Gln Pro Ala Val Cys Phe Leu Glu Val Leu Val Val 
        35                  40                  45              


Phe Lys Tyr Lys 
    50          

<210>  3289
<211>  348
<212>  DNA
<213>  Homo sapiens

<400>  3289
ggcaccgtct acaaacgggg tttaaaatga gctagcgcca tctactgggc gaatgccgta     60

aggtcggttg tgaggtcccg gaatctgcaa aggaatgaat gaattacaaa tctgtggctt    120

tatgggggga atgtcgagaa tcgggcacac gctgaagtgt gagaaccact gccattatgg    180

agaagaggct tcccgccccc tcacctgcca ctctagaaat ccagagaaga gattccactt    240

ggattaagac ttgcataagt ggggagttga gtccagtctc tttcccccac tgcaataccc    300

tgttgcggtg acatgtaata ataataaaaa gacttgcatg aactcctt                 348


<210>  3290
<211>  50
<212>  PRT
<213>  Homo sapiens

<400>  3290


Met Asn Glu Leu Gln Ile Cys Gly Phe Met Gly Gly Met Ser Arg Ile 
1               5                   10                  15      


Gly His Thr Leu Lys Cys Glu Asn His Cys His Tyr Gly Glu Glu Ala 
            20                  25                  30          


Ser Arg Pro Leu Thr Cys His Ser Arg Asn Pro Glu Lys Arg Phe His 
        35                  40                  45              


Leu Asp 
    50  

<210>  3291
<211>  982
<212>  DNA
<213>  Homo sapiens

<400>  3291
caggggagga aaggtcttga gggagcagca cgcttgcctg atgggtgccc aaagccaggg     60

gcaggtggag gtgagagaag gacaagctct gcaaacgttg cggaagcgct ctgtccatgg    120

agaaggcaca ggacttccat gtggggagca gcttactcct gctgagaact ttggggagac    180

agagtggagc agccatctca gacctgagcg gctaaggagc tgggtccccc tctgtcgcac    240

tgtgcagagc tgctggactt tgcagtaagc agccttcagg tctaaaggct ccacattgta    300

aggaagccca gtcacatgga cagaccatat gggtccagtt ggctgcccca gccaaggttt    360

cagccaacag ccaagattac ccacagccac gtgtatgaat gagccttcaa atgagtccag    420

cacccagcag aataatgccc cctcccgtct cacaaagatt tccatgccct aattcctgga    480

acctgtgaat ctgctacatc acatggcaag cagagctggc agatggaatt tagggtgtgg    540

agcttgaggt ggggagggca gcctggatta cacaggtggg ccctatctaa gcacatgagc    600

ccttatacaa gcaaagaaca tttcctcagc tgccagacag ctggcaaaca gaattggagg    660

ggcagagaga tgtaatcaga aagggcagaa gagacttaaa aggaagagag gctcgacctg    720

ctgtggctac ctttgaaaat ggaggaatgg ggctccaagc caagggatgc aggctgcctc    780

ttcattggag tactgccagc aagaaaacag cccagcaatt gcaaggaaat taattttccc    840

aacagtctga atgagcaaga aaatggactc tcccctgcca cgccctgagt tcagccttgt    900

gagactctaa gcagataccc actcaagccc acaggacgtc caacccataa caattgtaag    960

ataataaact gggatagttt ta                                             982


<210>  3292
<211>  75
<212>  PRT
<213>  Homo sapiens

<400>  3292


Met Gly Ala Gln Ser Gln Gly Gln Val Glu Val Arg Glu Gly Gln Ala 
1               5                   10                  15      


Leu Gln Thr Leu Arg Lys Arg Ser Val His Gly Glu Gly Thr Gly Leu 
            20                  25                  30          


Pro Cys Gly Glu Gln Leu Thr Pro Ala Glu Asn Phe Gly Glu Thr Glu 
        35                  40                  45              


Trp Ser Ser His Leu Arg Pro Glu Arg Leu Arg Ser Trp Val Pro Leu 
    50                  55                  60                  


Cys Arg Thr Val Gln Ser Cys Trp Thr Leu Gln 
65                  70                  75  

<210>  3293
<211>  959
<212>  DNA
<213>  Homo sapiens

<400>  3293
taaccaggac aaatggatag tgctttgggg atgactacca gaataaatca gttctaaacc     60

ttttccatat ttgtgtcact tcgctcagga cttcatttcc ctgtagggag agactggtgg    120

acttagcttg tggcaacaat taacactgtg tgccagagag gagggcagga tacctgaatt    180

gaaggttcca tcaagagcac aggcaggggt gattgaacca agccttcacc gcaccgagtt    240

tgccctactg cagtcaccca caccgcggct cgcttacggt tggagaaatc aaggccctac    300

cggggccacc tctctgttgt gggcgtggac gaggctgggg tgagcctgcc ggagctgcag    360

ttgccagcga catgttcaag gtaattcaga agggtccgtg gggccagcca gccggagctt    420

gttcaccttc agagtctgtg cagcaccgaa aaaggactca cctcccaaaa cttccgtgaa    480

ggttgacgag ctttcgcgag ggcaaatcgc agtgtgtgga ggagtcaagg aaccagcttg    540

aagaaagctt ctcacagctc cgacacttat tgcgagccat acacaagctg gtgtcaggac    600

acgtactccc aaagtcccac caatcccgta ctagctgtgg cttccaaaaa caagcacttg    660

agggctttct ctggcattct gggctggtga tagacacaag gattgcaggg cttgatattc    720

ccaagaaata gctctctgtc aatgacaggg tttggaactc gcgtggagcc gtaataaaca    780

cctggcagga tatctccaag gctgggaaat cattccccac ttaaggaggt ttgaatagag    840

acaataggca ctcgcaggca ataaaatgac aacaaaagca agaaagcctg tctgctgaat    900

aactgaagaa gcctaagact gagatatgat tgagttaaga aaaaaaatgt gtatatata     959


<210>  3294
<211>  35
<212>  PRT
<213>  Homo sapiens

<400>  3294


Met Phe Lys Val Ile Gln Lys Gly Pro Trp Gly Gln Pro Ala Gly Ala 
1               5                   10                  15      


Cys Ser Pro Ser Glu Ser Val Gln His Arg Lys Arg Thr His Leu Pro 
            20                  25                  30          


Lys Leu Pro 
        35  

<210>  3295
<211>  1137
<212>  DNA
<213>  Homo sapiens

<400>  3295
taaccaggac aaatggatag tgctttgggg atgactacca gaataaatca gttctaaacc     60

ttttccatat ttgtgtcact tcgctcagga cttcatttcc ctgtagggag agactggtgg    120

acttagcttg tggcaacaat taacactgtg tgccagagag gagggcagga tacctgaatt    180

gaaggttcca tcaagagcac aggcaggggt gattgaacca agccttcacc gcaccgagtt    240

tgccctactg cagtcaccca caccgcggct cgcttacggt tggagaaatc aaggccctac    300

cggggccacc tctctgttgt gggcgtggac gaggctgggg tgagcctgcc ggagctgcag    360

ttgccagcga catgttcaag gtaattcaga agggtccgtg gggccagcca gccggagctt    420

gttcaccttc agagtctgtg cagcaccgaa aaaggactca cctcccaaaa cttccgtgaa    480

ggttgacgag ctttcgcgag ggcaaatcgc agtgtgtgga ggagtcaagg aaccagcttg    540

aagaaagctt ctcacagctc cgacacttat tgcgagccat acacaagctg gtgtcaggac    600

acgtactccc aaagtcccac caatcccgta ctagctgtgg cttccaaaaa caagcacttg    660

agggctttct ctggcattct gggctggtga tagacacaag gattgcaggg cttgatattc    720

ccaagaaata gctctctgtc aatgacagcc ttaggcacaa ctggactttc aatcacacat    780

attttcccag agaggtgcat gacaaaggtg cccagcacat cctcaactgg aaatagagtt    840

ggcctgttgc ccaggctgga gtgcaatggc gcgatctcag ctcactgcaa cctcctcctc    900

tcggatgaag agactaaaat ttatagagat ggaaagactg aatgcactat atcatagtta    960

taacagcatg gatctacata acacatgagc aaagacaaat tcgcattcct tttttgaagc   1020

aactttaatg acaacatttg tgaataattg taaaattcca agtgcagtcc ttggtacatg   1080

ttaggtgctc aatacatttt agttctctaa ttctttatca aataaactta gtagtaa      1137


<210>  3296
<211>  71
<212>  PRT
<213>  Homo sapiens

<400>  3296


Met Thr Ala Leu Gly Thr Thr Gly Leu Ser Ile Thr His Ile Phe Pro 
1               5                   10                  15      


Glu Arg Cys Met Thr Lys Val Pro Ser Thr Ser Ser Thr Gly Asn Arg 
            20                  25                  30          


Val Gly Leu Leu Pro Arg Leu Glu Cys Asn Gly Ala Ile Ser Ala His 
        35                  40                  45              


Cys Asn Leu Leu Leu Ser Asp Glu Glu Thr Lys Ile Tyr Arg Asp Gly 
    50                  55                  60                  


Lys Thr Glu Cys Thr Ile Ser 
65                  70      

<210>  3297
<211>  1216
<212>  DNA
<213>  Homo sapiens

<400>  3297
ggatttgtaa agatattgat tccagataat gtttgccttt ctaactctct cttccttaga     60

cttgatggat aggttcaggg ctacatctcg gcagccaact caccgcagct acccagggaa    120

agaggaatgg aaaacgagct cggaagatat aagttacaac ccccagaagt ctagcctagc    180

gctattggat ggtgtccagc tttgccggaa ttagagagca ccagctcagg cacaaagcgg    240

cagttgcata gagtgctccg tggtcagtgg ctgtcctcaa gtgccccagt cagctcggct    300

gagcccaaag cctcccatct ctgcattcag gggctctctt cttcccccat ccatcaccag    360

ggaccagtga tcttgcctgt cgatgcccgg ctctcgcttg atgtctcagt tccggaacag    420

agatgctcca gctactacct gggaaggctc tggccccaaa aatatttagt tagcagccat    480

tcagttaagt ggaattgact ttttatcggc tttcctctgt acggctgcca ccagcgaagg    540

ctgtttcctt cttccctctt ctctgcctgt cagtttcctc cacattccta tcggcagcct    600

ttagctctga tcgatactaa ccgctgtgta acagctcacg cacgactgct ctggtttgca    660

tcgatcagac ccttcttcca acaggtagtc agctatttga ggcaatgact tgagataaac    720

acctactttt acttcaggct aattcatttc aggtggattt caaggaggcc ctgcaccccg    780

tctcttagac aagctgaaat tggagagtca agatccacgc actgcatgct tgagatccta    840

ggagaccttt cttcctctcc cgttttcttt ttctttccct tgtattttgt aagtgccact    900

tataaacaag ataccaggac tcaggacgtt gaaaatgcca cttcagaaaa tgtgtcggcc    960

atccatccct ctgtcctttt aatgagatgc atccgggact gcaggaaacc aagactgctg   1020

cggaggcagg attgtcgctg ggcaaccaag catccttcca gctgccccag aaagaatctc   1080

acaatgtcct gcaatccctg gtcttctcac cacctcaggg ggcggtcctt gaatccaccc   1140

ccatccttgt tccaggctca caagtgaaat ttaccaggag ctgatattgc aaaatagatt   1200

gctatttcgc aactga                                                   1216


<210>  3298
<211>  61
<212>  PRT
<213>  Homo sapiens

<400>  3298


Met Phe Ala Phe Leu Thr Leu Ser Ser Leu Asp Leu Met Asp Arg Phe 
1               5                   10                  15      


Arg Ala Thr Ser Arg Gln Pro Thr His Arg Ser Tyr Pro Gly Lys Glu 
            20                  25                  30          


Glu Trp Lys Thr Ser Ser Glu Asp Ile Ser Tyr Asn Pro Gln Lys Ser 
        35                  40                  45              


Ser Leu Ala Leu Leu Asp Gly Val Gln Leu Cys Arg Asn 
    50                  55                  60      

<210>  3299
<211>  4230
<212>  DNA
<213>  Homo sapiens

<400>  3299
gactgggagc aggcagcccg ggcggagcgg gccggtgccg aggacggccc caggcattgc     60

tctgccccgg gcattgcgcg gcgcgcgtga gggggatgcg gcaggaggcg gcgcggcggg    120

aggagtaggc ggcggcgccc tcgggaggga gctgcgcgcg ggccagacgg cgcccggagg    180

ctccgcagtg ccgccgccgt cgcccgggag gctccgcgcg ggagccatgt aaccctgcgg    240

cgggctccgg gctgctccgt ccttccccag ctcccgggct agcgcggcag cggggccacg    300

atgaagaagc agttcaatcg catgcgccag ctggccaacc agacggtggg cagggctgaa    360

aagacagaag ttttgagtga agaccttctt caggtggaga agcgtctgga gctggtgaaa    420

caggtgtccc acagcacgca caagaagctc accgcatgtc tgcagggcca gcaaggggca    480

gaggctgaca agcgctccaa aaagttgcct ttgacaacac tggctcagtg tctgatggag    540

gggtcagcta tcctgggaga tgacacactt cttgggaaga tgctgaaact ctgtggagag    600

acggaggaca agctggctca ggagctgata cattttgagt tgcaagtaga gagagacgtg    660

attgagcccc tgtttttgct ggcggaggtg gaaatcccaa atattcaaaa gcagaggaaa    720

cacttagcca agttggtgct ggacatggat tcctcacgaa ccaggtggca gcagacttcc    780

aagtcttcag gtttgtccag cagcttacag cctgcgggtg ccaaggctga tgccctcagg    840

gaagaaatgg aagaggctgc caacagagtg gagatttgca gggaccagct ctcagctgat    900

atgtacagtt ttgtggccaa agaaattgac tatgcaaact actttcaaac gctaatagaa    960

gtgcaagctg aataccacag gaagtccctg acactattgc aggctgtatt gcctcagatc   1020

aaagcacaac aggaggcctg ggtagagaag ccttccttcg ggaagccgct ggaggagcac   1080

ctcaccatca gcggccggga gatcgccttc cccatcgagg cgtgtgtgac catgctgctt   1140

gagtgtggga tgcaggagga gggactcttc cgagtagccc cctctgcctc caaactgaag   1200

aagctgaaag cggccctgga ctgctgcgtg gtggatgtgc aggagtactc ggcagacccc   1260

cacgcaattg caggagcttt gaaatcttac ctccgagagt tgccagaacc tcttatgacc   1320

tttgaactct atgatgagtg gatccaggct tccaatgtcc aggagcaaga caagaagctt   1380

caggctctat ggaatgcttg tgaaaagttg cccaaggcca atcacaacaa catccgatac   1440

ttgataaaat ttttatccaa gctgtcagaa tatcaagatg taaacaagat gactcccagt   1500

aatatggcaa ttgttttagg acccaacctc ctatggccac aagcagaagg gaacattaca   1560

gagatgatga ccacagtgtc gctgcaaatt gttgggatca ttgaacctat catccagcat   1620

gcagactggt tcttccctgg ggagatagag ttcaacatta ctggcaatta tgggagtcca   1680

gtacacgtga accataatgc caactacagc tcaatgccct ccccagacat ggaccctgct   1740

gaccggcgcc agcccgagca ggcccgccgg cccctcagcg tcgccacgga taatatgatg   1800

ctggagtttt acaaaaagga tggccttagg aaaatccaaa gcatgggtgt gagggtcatg   1860

gacacaaact gggtggctcg aagaggctcc tcggccggtc ggaaagtgtc ctgcgccccg   1920

ccctccatgc agcctcccgc cccgcccgcc gagctggctg cgcccctgcc ttcgccgctg   1980

ccggagcagc ccctggacag ccccgcggcc cccgcgctct ctccatccgg cctgggcctc   2040

cagcctgggc ccgagcgcac cagcacaaca aaaagcaagg aactttctcc aggctctgca   2100

cagaaaggaa gtccaggctc cagccagggc acagcctgtg cagggactca accaggggct   2160

caacctggag ctcagccggg cgccagcccc agccccagcc agccgcctgc agaccagagt   2220

cctcacaccc tccggaaagt ttcaaagaag ctggcaccga ttccacccaa ggtccccttt   2280

ggccagccgg gggctatggc agaccagtcc gctggccagc cgtccccagt cagcctgtcc   2340

cccaccccgc ccagcacccc gtcaccctat ggactgagct accctcaggg gtactccttg   2400

gcctcgggcc agctctcccc agctgcagct cctcccctgg cctctccttc tgtctttaca   2460

agcactttga gcaaatcgcg gcccactcct aagccgcgac agagacctac tctgccgcct   2520

cctcagcctc ccacagtaaa cctctcggcc tctagtccac agtccacgga ggcccccatg   2580

ctagatggca tgtcccctgg ggaaagcatg tctacagatc ttgtccactt tgatattccc   2640

tcgatccaca tagagctcgg gtcgacgctc cgcctgagtc ccctggagca catgcggcga   2700

cactcagtaa ctgacaagag ggactcggag gaggagtctg agagcaccgc cctctgacat   2760

gacaccgccc atcctgcctc gcgtgtacat acatcacggg ccctaggaac gccgccagga   2820

gcagcgtcca tgagcttgcc aagtgttctc tgctggctct ttcctgccac tgccaacacg   2880

aggttggaat ttggcagaaa attgtgatct ccagtccgtg tggtgatgct ggtggtgcag   2940

gttttgtttg ttcctttcgg gtggtgactt cggccttttg tttgaccttt gccttttgac   3000

tttgtgcctc ttttgatcca ctttcagcct ccatgccaga aaacacccac ctctccatcc   3060

aaggctggtc aggaacgtcc tttgcagggt cggggtggtg cgggagaggc tcactttgcc   3120

tggttagacc caagggctgc taccttttcc ttggacggct catgtcaggt cttgcaggat   3180

cagtttaatg gccacagaaa ggaagcagga cagcagggcc cctctcaccc acaactggac   3240

caggtccagg attctagcag tcctggggca ctgacctttg ccagctacct gggggagggc   3300

ttgccactgg aaaacctttc aggccgcccc catcagtggg ctccaaagta aatggctgaa   3360

aacaaaaatg tttcacttcc taacagtttt cctttttcca ctgtgtgact gaaagctcct   3420

atatcatttt atatttctga atctataaaa caaaacaaac aagcctgaca gtgtctggag   3480

gagccaaagg tggcctccct gtccccaaat atattggcta tatgagagta attttacccc   3540

tctacgtacc taaaggcacc cagttcacta gtctgtgggg tcctggagcc tgtctcttct   3600

ttctggaggt tcaaactgaa tagcaataat tacgttaccc aaagcatgtg gaggaaaagt   3660

gaaaccagcc acggagacgc tggcccacgg gctcggcctg cggtgtggcc tgctttgctc   3720

accagcgtca gccgctcatt tccttctcat gaagtcccat ctggtcatgg ggacgagggc   3780

cgggagggca ccgggtagcc ttttcacact tggggattag gggagtgaga aaagatttgg   3840

gccatgcatg caaagtcaaa gtttaaaatt ttatcctttt caaatagatg atataatata   3900

cctatacatg atataatatt tgtatatatg aaatctctct atatttgttt aatttgagcc   3960

attcaatcta aaccaatgta caggtgtaca atgaaaaatt taaatgctta gttatttttc   4020

ccaacacagt gtaaagtcac cctcctctga gagtgggatg tgcagagttt tgatgttgca   4080

gctttgctca cttcctggca agggcaggtc atgcctcaat ttgtaatggg agtctggggt   4140

aagggtgggg gttgaaagtt gttatcttta aatacatgta caaatcgttg tcaaaagtaa   4200

cgttattaaa atagatttat tatccctgag                                    4230


<210>  3300
<211>  818
<212>  PRT
<213>  Homo sapiens

<400>  3300


Met Lys Lys Gln Phe Asn Arg Met Arg Gln Leu Ala Asn Gln Thr Val 
1               5                   10                  15      


Gly Arg Ala Glu Lys Thr Glu Val Leu Ser Glu Asp Leu Leu Gln Val 
            20                  25                  30          


Glu Lys Arg Leu Glu Leu Val Lys Gln Val Ser His Ser Thr His Lys 
        35                  40                  45              


Lys Leu Thr Ala Cys Leu Gln Gly Gln Gln Gly Ala Glu Ala Asp Lys 
    50                  55                  60                  


Arg Ser Lys Lys Leu Pro Leu Thr Thr Leu Ala Gln Cys Leu Met Glu 
65                  70                  75                  80  


Gly Ser Ala Ile Leu Gly Asp Asp Thr Leu Leu Gly Lys Met Leu Lys 
                85                  90                  95      


Leu Cys Gly Glu Thr Glu Asp Lys Leu Ala Gln Glu Leu Ile His Phe 
            100                 105                 110         


Glu Leu Gln Val Glu Arg Asp Val Ile Glu Pro Leu Phe Leu Leu Ala 
        115                 120                 125             


Glu Val Glu Ile Pro Asn Ile Gln Lys Gln Arg Lys His Leu Ala Lys 
    130                 135                 140                 


Leu Val Leu Asp Met Asp Ser Ser Arg Thr Arg Trp Gln Gln Thr Ser 
145                 150                 155                 160 


Lys Ser Ser Gly Leu Ser Ser Ser Leu Gln Pro Ala Gly Ala Lys Ala 
                165                 170                 175     


Asp Ala Leu Arg Glu Glu Met Glu Glu Ala Ala Asn Arg Val Glu Ile 
            180                 185                 190         


Cys Arg Asp Gln Leu Ser Ala Asp Met Tyr Ser Phe Val Ala Lys Glu 
        195                 200                 205             


Ile Asp Tyr Ala Asn Tyr Phe Gln Thr Leu Ile Glu Val Gln Ala Glu 
    210                 215                 220                 


Tyr His Arg Lys Ser Leu Thr Leu Leu Gln Ala Val Leu Pro Gln Ile 
225                 230                 235                 240 


Lys Ala Gln Gln Glu Ala Trp Val Glu Lys Pro Ser Phe Gly Lys Pro 
                245                 250                 255     


Leu Glu Glu His Leu Thr Ile Ser Gly Arg Glu Ile Ala Phe Pro Ile 
            260                 265                 270         


Glu Ala Cys Val Thr Met Leu Leu Glu Cys Gly Met Gln Glu Glu Gly 
        275                 280                 285             


Leu Phe Arg Val Ala Pro Ser Ala Ser Lys Leu Lys Lys Leu Lys Ala 
    290                 295                 300                 


Ala Leu Asp Cys Cys Val Val Asp Val Gln Glu Tyr Ser Ala Asp Pro 
305                 310                 315                 320 


His Ala Ile Ala Gly Ala Leu Lys Ser Tyr Leu Arg Glu Leu Pro Glu 
                325                 330                 335     


Pro Leu Met Thr Phe Glu Leu Tyr Asp Glu Trp Ile Gln Ala Ser Asn 
            340                 345                 350         


Val Gln Glu Gln Asp Lys Lys Leu Gln Ala Leu Trp Asn Ala Cys Glu 
        355                 360                 365             


Lys Leu Pro Lys Ala Asn His Asn Asn Ile Arg Tyr Leu Ile Lys Phe 
    370                 375                 380                 


Leu Ser Lys Leu Ser Glu Tyr Gln Asp Val Asn Lys Met Thr Pro Ser 
385                 390                 395                 400 


Asn Met Ala Ile Val Leu Gly Pro Asn Leu Leu Trp Pro Gln Ala Glu 
                405                 410                 415     


Gly Asn Ile Thr Glu Met Met Thr Thr Val Ser Leu Gln Ile Val Gly 
            420                 425                 430         


Ile Ile Glu Pro Ile Ile Gln His Ala Asp Trp Phe Phe Pro Gly Glu 
        435                 440                 445             


Ile Glu Phe Asn Ile Thr Gly Asn Tyr Gly Ser Pro Val His Val Asn 
    450                 455                 460                 


His Asn Ala Asn Tyr Ser Ser Met Pro Ser Pro Asp Met Asp Pro Ala 
465                 470                 475                 480 


Asp Arg Arg Gln Pro Glu Gln Ala Arg Arg Pro Leu Ser Val Ala Thr 
                485                 490                 495     


Asp Asn Met Met Leu Glu Phe Tyr Lys Lys Asp Gly Leu Arg Lys Ile 
            500                 505                 510         


Gln Ser Met Gly Val Arg Val Met Asp Thr Asn Trp Val Ala Arg Arg 
        515                 520                 525             


Gly Ser Ser Ala Gly Arg Lys Val Ser Cys Ala Pro Pro Ser Met Gln 
    530                 535                 540                 


Pro Pro Ala Pro Pro Ala Glu Leu Ala Ala Pro Leu Pro Ser Pro Leu 
545                 550                 555                 560 


Pro Glu Gln Pro Leu Asp Ser Pro Ala Ala Pro Ala Leu Ser Pro Ser 
                565                 570                 575     


Gly Leu Gly Leu Gln Pro Gly Pro Glu Arg Thr Ser Thr Thr Lys Ser 
            580                 585                 590         


Lys Glu Leu Ser Pro Gly Ser Ala Gln Lys Gly Ser Pro Gly Ser Ser 
        595                 600                 605             


Gln Gly Thr Ala Cys Ala Gly Thr Gln Pro Gly Ala Gln Pro Gly Ala 
    610                 615                 620                 


Gln Pro Gly Ala Ser Pro Ser Pro Ser Gln Pro Pro Ala Asp Gln Ser 
625                 630                 635                 640 


Pro His Thr Leu Arg Lys Val Ser Lys Lys Leu Ala Pro Ile Pro Pro 
                645                 650                 655     


Lys Val Pro Phe Gly Gln Pro Gly Ala Met Ala Asp Gln Ser Ala Gly 
            660                 665                 670         


Gln Pro Ser Pro Val Ser Leu Ser Pro Thr Pro Pro Ser Thr Pro Ser 
        675                 680                 685             


Pro Tyr Gly Leu Ser Tyr Pro Gln Gly Tyr Ser Leu Ala Ser Gly Gln 
    690                 695                 700                 


Leu Ser Pro Ala Ala Ala Pro Pro Leu Ala Ser Pro Ser Val Phe Thr 
705                 710                 715                 720 


Ser Thr Leu Ser Lys Ser Arg Pro Thr Pro Lys Pro Arg Gln Arg Pro 
                725                 730                 735     


Thr Leu Pro Pro Pro Gln Pro Pro Thr Val Asn Leu Ser Ala Ser Ser 
            740                 745                 750         


Pro Gln Ser Thr Glu Ala Pro Met Leu Asp Gly Met Ser Pro Gly Glu 
        755                 760                 765             


Ser Met Ser Thr Asp Leu Val His Phe Asp Ile Pro Ser Ile His Ile 
    770                 775                 780                 


Glu Leu Gly Ser Thr Leu Arg Leu Ser Pro Leu Glu His Met Arg Arg 
785                 790                 795                 800 


His Ser Val Thr Asp Lys Arg Asp Ser Glu Glu Glu Ser Glu Ser Thr 
                805                 810                 815     


Ala Leu 
        

<210>  3301
<211>  4351
<212>  DNA
<213>  Homo sapiens

<400>  3301
gactgggagc aggcagcccg ggcggagcgg gccggtgccg aggacggccc caggcattgc     60

tctgccccgg gcattgcgcg gcgcgcgtga gggggatgcg gcaggaggcg gcgcggcggg    120

aggagtaggc ggcggcgccc tcgggaggga gctgcgcgcg ggccagacgg cgcccggagg    180

ctccgcagtg ccgccgccgt cgcccgggag gctccgcgcg ggagccatgt aaccctgcgg    240

cgggctccgg gctgctccgt ccttccccag ctcccgggct agcgcggcag cggggccacg    300

atgaagaagc agttcaatcg catgcgccag ctggccaacc agacggtggg cagggctgaa    360

aagacagaag ttttgagtga agaccttctt caggtggaga agcgtctgga gctggtgaaa    420

caggtgtccc acagcacgca caagaagctc accgcatgtc tgcagggcca gcaaggggca    480

gaggctgaca agcgctccaa aaagttgcct ttgacaacac tggctcagtg tctgatggag    540

gggtcagcta tcctgggaga tgacacactt cttgggaaga tgctgaaact ctgtggagag    600

acggaggaca agctggctca ggagctgata cattttgagt tgcaagtaga gagagacgtg    660

attgagcccc tgtttttgct ggcggaggtg gaaatcccaa atattcaaaa gcagaggaaa    720

cacttagcca agttggtgct ggacatggat tcctcacgaa ccaggtggca gcagacttcc    780

aagtcttcag gtttgtccag cagcttacag cctgcgggtg ccaaggctga tgccctcagg    840

gaagaaatgg aagaggctgc caacagagtg gagatttgca gggaccagct ctcagctgat    900

atgtacagtt ttgtggccaa agaaattgac tatgcaaact actttcaaac gctaatagaa    960

gtgcaagctg aataccacag gaagtccctg acactattgc aggctgtatt gcctcagatc   1020

aaagcacaac aggaggcctg ggtagagaag ccttccttcg ggaagccgct ggaggagcac   1080

ctcaccatca gcggccggga gatcgccttc cccatcgagg cgtgtgtgac catgctgctt   1140

gagtgtggga tgcaggagga gggactcttc cgagtagccc cctctgcctc caaactgaag   1200

aagctgaaag cggccctgga ctgctgcgtg gtggatgtgc aggagtactc ggcagacccc   1260

cacgcaattg caggagcttt gaaatcttac ctccgagagt tgccagaacc tcttatgacc   1320

tttgaactct atgatgagtg gatccaggct tccaatgtcc aggagcaaga caagaagctt   1380

caggctctat ggaatgcttg tgaaaagttg cccaaggcca atcacaacaa catccgatac   1440

ttgataaaat ttttatccaa gctgtcagaa tatcaagatg taaacaagat gactcccagt   1500

aatatggcaa ttgttttagg acccaacctc ctatggccac aagcagaagg gaacattaca   1560

gagatgatga ccacagtgtc gctgcaaatt gttgggatca ttgaacctat catccagcat   1620

gcagactggt tcttccctgg ggagatagag ttcaacatta ctggcaatta tgggagtcca   1680

gtacacgtga accataatgc caactacagc tcaatgccct ccccagacat ggaccctgct   1740

gaccggcgcc agcccgagca ggcccgccgg cccctcagcg tcgccacgga taatatgatg   1800

ctggagtttt acaaaaagga tggccttagg aaaatccaaa gcatgggtgt gagggtcatg   1860

gacacaaact gggtggctcg aagaggctcc tcggccggtc ggaaagtgtc ctgcgccccg   1920

ccctccatgc agcctcccgc cccgcccgcc gagctggctg cgcccctgcc ttcgccgctg   1980

ccggagcagc ccctggacag ccccgcggcc cccgcgctct ctccatccgg cctgggcctc   2040

cagcctgggc ccgagcgcac cagcacaaca aaaagcaagg aactttctcc aggctctgca   2100

cagaaaggaa gtccaggctc cagccagggc acagcctgtg cagggactca accaggggct   2160

caacctggag ctcagccggg cgccagcccc agccccagcc agccgcctgc agaccagagt   2220

cctcacaccc tccggaaagt ttcaaagaag ctggcaccga ttccacccaa ggtccccttt   2280

ggccagccgg gggctatggc agaccagtcc gctggccagc cgtccccagt cagcctgtcc   2340

cccaccccgc ccagcacccc gtcaccctat ggactgagct accctcaggg gtactccttg   2400

gcctcgggcc agctctcccc agctgcagct cctcccctgg cctctccttc tgtctttaca   2460

agcactttga gcaaatcgcg gcccactcct aagccgcgac agagacctac tctgccgcct   2520

cctcagcctc ccacagtaaa cctctcggcc tctagtccac agtccacgga ggcccccatg   2580

ctagatggca tgtcccctgg ggaaagcatg tctacagatc ttgtccactt tgatattccc   2640

tcgatccaca tagagctcgg gtcgacgctc cgcctgagtc ccctggagca catgcggcga   2700

cactcagtaa ctgacaagag ggactcggag gaggagtctg agagcaccgc cctctgacat   2760

gacaccgccc atcctgcctc gcgtgtacat acatcacggg ccctaggaac gccgccagga   2820

gcagcgtcca tgagcttgcc aagtgttctc tgctggctct ttcctgccac tgccaacacg   2880

aggttggaat ttggcagaaa attgtgatct ccagtccgtg tggtgatgct ggtggtgcag   2940

gttttgtttg ttcctttcgg gtggtgactt cggccttttg tttgaccttt gccttttgac   3000

tttgtgcctc ttttgatcca ctttcagcct ccatgccaga aaacacccac ctctccatcc   3060

aaggctggtc aggaacgtcc tttgcagggt cggggtggtg cgggagaggc tcactttgcc   3120

tggttagacc caagggctgc taccttttcc ttggacggct catgtcaggt cttgcaggat   3180

cagtttaatg gccacagaaa ggaagcagga cagcagggcc cctctcaccc acaactggac   3240

caggtccagg attctagcag tcctggggca ctgacctttg ccagctacct gggggagggc   3300

ttgccactgg aaaacctttc aggccgcccc catcagtggg ctccaaagta aatggctgaa   3360

aacaaaaatg tttcacttcc taacagtttt cctttttcca ctgtgtgact gaaagctcct   3420

atatcatttt atatttctga atctataaaa caaaacaaac aagcctgaca gtgtctggag   3480

gagccaaagg tggcctccct gtccccaaat atattggcta tatgagagta attttacccc   3540

tctacgtacc taaaggcacc cagttcacta gtctgtgggg tcctggagcc tgtctcttct   3600

ttctggaggt tcaaactgaa tagcaataat tacgttaccc aaagcatgtg gaggaaaagt   3660

gaaaccagcc acggagacgc tggcccacgg gctcggcctg cggtgtggcc tgctttgctc   3720

accagcgtca gccgctcatt tccttctcat gaagtcccat ctggtcatgg ggacgagggc   3780

cgggagggca ccgggtagcc ttttcacact tggggattag gggagtgaga aaagatttgg   3840

gccatgcatg caaagtcaaa gtttaaaatt ttatcctttt caaatagatg atataatata   3900

cctatacatg atataatatt tgtatatatg aaatctctct atatttgttt aatttgagcc   3960

attcaatcta aaccaatgta caggtgtaca atgaaaaatt taaatgctta gttatttttc   4020

ccaacacagt gtaaagtcac cctcctctga gagtgggatg tgcagagttt tgatgttgca   4080

gctttgctca cttcctggca agggcaggtc atgcctcaat ttgtaatggg agtctggggt   4140

aagggtgggg gttgaaagtt gttatcttta aatacatgta caaatcgttg tcaaaagtaa   4200

cgttattaaa atagatttat tatccctgag cttggcatct gttcttgctt taataaacct   4260

gcggggacat ggccgtcaat ctcaaatgca caccgggatg gagcctgaag gtcaccacct   4320

gtgtaaagcc aggtccctgg ctgatctctc g                                  4351


<210>  3302
<211>  818
<212>  PRT
<213>  Homo sapiens

<400>  3302


Met Lys Lys Gln Phe Asn Arg Met Arg Gln Leu Ala Asn Gln Thr Val 
1               5                   10                  15      


Gly Arg Ala Glu Lys Thr Glu Val Leu Ser Glu Asp Leu Leu Gln Val 
            20                  25                  30          


Glu Lys Arg Leu Glu Leu Val Lys Gln Val Ser His Ser Thr His Lys 
        35                  40                  45              


Lys Leu Thr Ala Cys Leu Gln Gly Gln Gln Gly Ala Glu Ala Asp Lys 
    50                  55                  60                  


Arg Ser Lys Lys Leu Pro Leu Thr Thr Leu Ala Gln Cys Leu Met Glu 
65                  70                  75                  80  


Gly Ser Ala Ile Leu Gly Asp Asp Thr Leu Leu Gly Lys Met Leu Lys 
                85                  90                  95      


Leu Cys Gly Glu Thr Glu Asp Lys Leu Ala Gln Glu Leu Ile His Phe 
            100                 105                 110         


Glu Leu Gln Val Glu Arg Asp Val Ile Glu Pro Leu Phe Leu Leu Ala 
        115                 120                 125             


Glu Val Glu Ile Pro Asn Ile Gln Lys Gln Arg Lys His Leu Ala Lys 
    130                 135                 140                 


Leu Val Leu Asp Met Asp Ser Ser Arg Thr Arg Trp Gln Gln Thr Ser 
145                 150                 155                 160 


Lys Ser Ser Gly Leu Ser Ser Ser Leu Gln Pro Ala Gly Ala Lys Ala 
                165                 170                 175     


Asp Ala Leu Arg Glu Glu Met Glu Glu Ala Ala Asn Arg Val Glu Ile 
            180                 185                 190         


Cys Arg Asp Gln Leu Ser Ala Asp Met Tyr Ser Phe Val Ala Lys Glu 
        195                 200                 205             


Ile Asp Tyr Ala Asn Tyr Phe Gln Thr Leu Ile Glu Val Gln Ala Glu 
    210                 215                 220                 


Tyr His Arg Lys Ser Leu Thr Leu Leu Gln Ala Val Leu Pro Gln Ile 
225                 230                 235                 240 


Lys Ala Gln Gln Glu Ala Trp Val Glu Lys Pro Ser Phe Gly Lys Pro 
                245                 250                 255     


Leu Glu Glu His Leu Thr Ile Ser Gly Arg Glu Ile Ala Phe Pro Ile 
            260                 265                 270         


Glu Ala Cys Val Thr Met Leu Leu Glu Cys Gly Met Gln Glu Glu Gly 
        275                 280                 285             


Leu Phe Arg Val Ala Pro Ser Ala Ser Lys Leu Lys Lys Leu Lys Ala 
    290                 295                 300                 


Ala Leu Asp Cys Cys Val Val Asp Val Gln Glu Tyr Ser Ala Asp Pro 
305                 310                 315                 320 


His Ala Ile Ala Gly Ala Leu Lys Ser Tyr Leu Arg Glu Leu Pro Glu 
                325                 330                 335     


Pro Leu Met Thr Phe Glu Leu Tyr Asp Glu Trp Ile Gln Ala Ser Asn 
            340                 345                 350         


Val Gln Glu Gln Asp Lys Lys Leu Gln Ala Leu Trp Asn Ala Cys Glu 
        355                 360                 365             


Lys Leu Pro Lys Ala Asn His Asn Asn Ile Arg Tyr Leu Ile Lys Phe 
    370                 375                 380                 


Leu Ser Lys Leu Ser Glu Tyr Gln Asp Val Asn Lys Met Thr Pro Ser 
385                 390                 395                 400 


Asn Met Ala Ile Val Leu Gly Pro Asn Leu Leu Trp Pro Gln Ala Glu 
                405                 410                 415     


Gly Asn Ile Thr Glu Met Met Thr Thr Val Ser Leu Gln Ile Val Gly 
            420                 425                 430         


Ile Ile Glu Pro Ile Ile Gln His Ala Asp Trp Phe Phe Pro Gly Glu 
        435                 440                 445             


Ile Glu Phe Asn Ile Thr Gly Asn Tyr Gly Ser Pro Val His Val Asn 
    450                 455                 460                 


His Asn Ala Asn Tyr Ser Ser Met Pro Ser Pro Asp Met Asp Pro Ala 
465                 470                 475                 480 


Asp Arg Arg Gln Pro Glu Gln Ala Arg Arg Pro Leu Ser Val Ala Thr 
                485                 490                 495     


Asp Asn Met Met Leu Glu Phe Tyr Lys Lys Asp Gly Leu Arg Lys Ile 
            500                 505                 510         


Gln Ser Met Gly Val Arg Val Met Asp Thr Asn Trp Val Ala Arg Arg 
        515                 520                 525             


Gly Ser Ser Ala Gly Arg Lys Val Ser Cys Ala Pro Pro Ser Met Gln 
    530                 535                 540                 


Pro Pro Ala Pro Pro Ala Glu Leu Ala Ala Pro Leu Pro Ser Pro Leu 
545                 550                 555                 560 


Pro Glu Gln Pro Leu Asp Ser Pro Ala Ala Pro Ala Leu Ser Pro Ser 
                565                 570                 575     


Gly Leu Gly Leu Gln Pro Gly Pro Glu Arg Thr Ser Thr Thr Lys Ser 
            580                 585                 590         


Lys Glu Leu Ser Pro Gly Ser Ala Gln Lys Gly Ser Pro Gly Ser Ser 
        595                 600                 605             


Gln Gly Thr Ala Cys Ala Gly Thr Gln Pro Gly Ala Gln Pro Gly Ala 
    610                 615                 620                 


Gln Pro Gly Ala Ser Pro Ser Pro Ser Gln Pro Pro Ala Asp Gln Ser 
625                 630                 635                 640 


Pro His Thr Leu Arg Lys Val Ser Lys Lys Leu Ala Pro Ile Pro Pro 
                645                 650                 655     


Lys Val Pro Phe Gly Gln Pro Gly Ala Met Ala Asp Gln Ser Ala Gly 
            660                 665                 670         


Gln Pro Ser Pro Val Ser Leu Ser Pro Thr Pro Pro Ser Thr Pro Ser 
        675                 680                 685             


Pro Tyr Gly Leu Ser Tyr Pro Gln Gly Tyr Ser Leu Ala Ser Gly Gln 
    690                 695                 700                 


Leu Ser Pro Ala Ala Ala Pro Pro Leu Ala Ser Pro Ser Val Phe Thr 
705                 710                 715                 720 


Ser Thr Leu Ser Lys Ser Arg Pro Thr Pro Lys Pro Arg Gln Arg Pro 
                725                 730                 735     


Thr Leu Pro Pro Pro Gln Pro Pro Thr Val Asn Leu Ser Ala Ser Ser 
            740                 745                 750         


Pro Gln Ser Thr Glu Ala Pro Met Leu Asp Gly Met Ser Pro Gly Glu 
        755                 760                 765             


Ser Met Ser Thr Asp Leu Val His Phe Asp Ile Pro Ser Ile His Ile 
    770                 775                 780                 


Glu Leu Gly Ser Thr Leu Arg Leu Ser Pro Leu Glu His Met Arg Arg 
785                 790                 795                 800 


His Ser Val Thr Asp Lys Arg Asp Ser Glu Glu Glu Ser Glu Ser Thr 
                805                 810                 815     


Ala Leu 
        

<210>  3303
<211>  4145
<212>  DNA
<213>  Homo sapiens

<400>  3303
actgggagca ggcagcccgg gcggagcggg ccggtgccga ggacggcccc aggcattgct     60

ctgccccggg cattgcgcgg cgcgcgtgag ggggatgcgg caggaggcgg cgcggcggga    120

ggagtaggcg gcggcgccct cgggagggag ctgcgcgcgg gccagacggc gcccggaggc    180

tccgcagtgc cgccgccgtc gcccgggagg ctccgcgcgg gagccatgta accctgcggc    240

gggctccggg ctgctccgtc cttccccagc tcccgggcta gcgcggcagc ggggccacga    300

tgaagaagca gttcaatcgc atgcgccagc tggccaacca gacggtgggc agggctgaaa    360

agacagaagt tttgagtgaa gaccttcttc aggtggagaa gcgtctggag ctggtgaaac    420

aggtgtccca cagcacgcac aagaagctca ccgcatgtct gcagggccag caaggggcag    480

aggctgacaa gcgctccaaa aagttgcctt tgacaacact ggctcagtgt ctgatggagg    540

ggtcagctat cctgggagat gacacacttc ttgggaagat gctgaaactc tgtggagaga    600

cggaggacaa gctggctcag gagctgatac attttgagtt gcaagtagag agagacgtga    660

ttgagcccct gtttttgctg gcggaggtgg aaatcccaaa tattcaaaag cagaggaaac    720

acttagccaa gttggtgctg gacatggatt cctcacgaac caggaccagc tctcagctga    780

tatgtacagt tttgtggcca aagaaattga ctatgcaaac tactttcaaa cgctaataga    840

agtgcaagct gaataccaca ggaagtccct gacactattg caggctgtat tgcctcagat    900

caaagcacaa caggaggcct gggtagagaa gccttccttc gggaagccgc tggaggagca    960

cctcaccatc agcggccggg agatcgcctt ccccatcgag gcgtgtgtga ccatgctgct   1020

tgagtgtggg atgcaggagg agggactctt ccgagtagcc ccctctgcct ccaaactgaa   1080

gaagctgaaa gcggccctgg actgctgcgt ggtggatgtg caggagtact cggcagaccc   1140

ccacgcaatt gcaggagctt tgaaatctta cctccgagag ttgccagaac ctcttatgac   1200

ctttgaactc tatgatgagt ggatccaggc ttccaatgtc caggagcaag acaagaagct   1260

tcaggctcta tggaatgctt gtgaaaagtt gcccaaggcc aatcacaaca acatccgata   1320

cttgataaaa tttttatcca agctgtcaga atatcaagat gtaaacaaga tgactcccag   1380

taatatggca attgttttag gacccaacct cctatggcca caagcagaag ggaacattac   1440

agagatgatg accacagtgt cgctgcaaat tgttgggatc attgaaccta tcatccagca   1500

tgcagactgg ttcttccctg gggagataga gttcaacatt actggcaatt atgggagtcc   1560

agtacacgtg aaccataatg ccaactacag ctcaatgccc tccccagaca tggaccctgc   1620

tgaccggcgc cagcccgagc aggcccgccg gcccctcagc gtcgccacgg ataatatgat   1680

gctggagttt tacaaaaagg atggcatggg tgtgagggtc atggacacaa actgggtggc   1740

tcgaagaggc tcctcggccg gtcggaaagt gtcctgcgcc ccgccctcca tgcagcctcc   1800

cgccccgccc gccgagctgg ctgcgcccct gccttcgccg ctgccggagc agcccctgga   1860

cagccccgcg gcccccgcgc tctctccatc cggcctgggc ctccagcctg ggcccgagcg   1920

caccagcaca acaaaaagca aggaactttc tccaggctct gcacagaaag gaagtccagg   1980

ctccagccag ggcacagcct gtgcagggac tcaaccaggg gctcaacctg gagctcagcc   2040

gggcgccagc cccagcccca gccagccgcc tgcagaccag agtcctcaca ccctccggaa   2100

agtttcaaag aagctggcac cgattccacc caaggtcccc tttggccagc cgggggctat   2160

ggcagaccag tccgctggcc agccgtcccc agtcagcctg tcccccaccc cgcccagcac   2220

cccgtcaccc tatggactga gctaccctca ggggtactcc ttggcctcgg gccagctctc   2280

cccagctgca gctcctcccc tggcctctcc ttctgtcttt acaagcactt tgagcaaatc   2340

gcggcccact cctaagccgc gacagagacc tactctgccg cctcctcagc ctcccacagt   2400

aaacctctcg gcctctagtc cacagtccac ggaggccccc atgctagatg gcatgtcccc   2460

tggggaaagc atgtctacag ctgtgtgaca tgagtggcgc agttttggat acgtgtgagg   2520

gggattttca ggatcttgtc cactttgata ttccctcgat ccacatagag ctcgggtcga   2580

cgctccgcct gagtcccctg gagcacatgc ggcgacactc agtaactgac aagagggact   2640

cggaggagga gtctgagagc accgccctct gacatgacac cgcccatcct gcctcgcgtg   2700

tacatacatc acgggcccta ggaacgccgc caggagcagc gtccatgagc ttgccaagtg   2760

ttctctgctg gctctttcct gccactgcca acacgaggtt ggaatttggc agaaaattgt   2820

gatctccagt ccgtgtggtg atgctggtgg tgcaggtttt gtttgttcct ttcgggtggt   2880

gacttcggcc ttttgtttga cctttgcctt ttgactttgt gcctcttttg atccactttc   2940

agcctccatg ccagaaaaca cccacctctc catccaaggc tggtcaggaa cgtcctttgc   3000

agggtcgggg tggtgcggga gaggctcact ttgcctggtt agacccaagg gctgctacct   3060

tttccttgga cggctcatgt caggtcttgc aggatcagtt taatggccac agaaaggaag   3120

caggacagca gggcccctct cacccacaac tggaccaggt ccaggattct agcagtcctg   3180

gggcactgac ctttgccagc tacctggggg agggcttgcc actggaaaac ctttcaggcc   3240

gcccccatca gtgggctcca aagtaaatgg ctgaaaacaa aaatgtttca cttcctaaca   3300

gttttccttt ttccactgtg tgactgaaag ctcctatatc attttatatt tctgaatcta   3360

taaaacaaaa caaacaagcc tgacagtgtc tggaggagcc aaaggtggcc tccctgtccc   3420

caaatatatt ggctatatga gagtaatttt acccctctac gtacctaaag gcacccagtt   3480

cactagtctg tggggtcctg gagcctgtct cttctttctg gaggttcaaa ctgaatagca   3540

ataattacgt tacccaaagc atgtggagga aaagtgaaac cagccacgga gacgctggcc   3600

cacgggctcg gcctgcggtg tggcctgctt tgctcaccag cgtcagccgc tcatttcctt   3660

ctcatgaagt cccatctggt catggggacg agggccggga gggcaccggg tagccttttc   3720

acacttgggg attaggggag tgagaaaaga tttgggccat gcatgcaaag tcaaagttta   3780

aaattttatc cttttcaaat agatgatata atatacctat acatgatata atatttgtat   3840

atatgaaatc tctctatatt tgtttaattt gagccattca atctaaacca atgtacaggt   3900

gtacaatgaa aaatttaaat gcttagttat ttttcccaac acagtgtaaa gtcaccctcc   3960

tctgagagtg ggatgtgcag agttttgatg ttgcagcttt gctcacttcc tggcaagggc   4020

aggtcatgcc tcaatttgta atgggagtct ggggtaaggg tgggggttga aagttgttat   4080

ctttaaatac atgtacaaat cgttgtcaaa agtaacgtta ttaaaataga tttattatcc   4140

ctgag                                                               4145


<210>  3304
<211>  568
<212>  PRT
<213>  Homo sapiens

<400>  3304


Met Tyr Ser Phe Val Ala Lys Glu Ile Asp Tyr Ala Asn Tyr Phe Gln 
1               5                   10                  15      


Thr Leu Ile Glu Val Gln Ala Glu Tyr His Arg Lys Ser Leu Thr Leu 
            20                  25                  30          


Leu Gln Ala Val Leu Pro Gln Ile Lys Ala Gln Gln Glu Ala Trp Val 
        35                  40                  45              


Glu Lys Pro Ser Phe Gly Lys Pro Leu Glu Glu His Leu Thr Ile Ser 
    50                  55                  60                  


Gly Arg Glu Ile Ala Phe Pro Ile Glu Ala Cys Val Thr Met Leu Leu 
65                  70                  75                  80  


Glu Cys Gly Met Gln Glu Glu Gly Leu Phe Arg Val Ala Pro Ser Ala 
                85                  90                  95      


Ser Lys Leu Lys Lys Leu Lys Ala Ala Leu Asp Cys Cys Val Val Asp 
            100                 105                 110         


Val Gln Glu Tyr Ser Ala Asp Pro His Ala Ile Ala Gly Ala Leu Lys 
        115                 120                 125             


Ser Tyr Leu Arg Glu Leu Pro Glu Pro Leu Met Thr Phe Glu Leu Tyr 
    130                 135                 140                 


Asp Glu Trp Ile Gln Ala Ser Asn Val Gln Glu Gln Asp Lys Lys Leu 
145                 150                 155                 160 


Gln Ala Leu Trp Asn Ala Cys Glu Lys Leu Pro Lys Ala Asn His Asn 
                165                 170                 175     


Asn Ile Arg Tyr Leu Ile Lys Phe Leu Ser Lys Leu Ser Glu Tyr Gln 
            180                 185                 190         


Asp Val Asn Lys Met Thr Pro Ser Asn Met Ala Ile Val Leu Gly Pro 
        195                 200                 205             


Asn Leu Leu Trp Pro Gln Ala Glu Gly Asn Ile Thr Glu Met Met Thr 
    210                 215                 220                 


Thr Val Ser Leu Gln Ile Val Gly Ile Ile Glu Pro Ile Ile Gln His 
225                 230                 235                 240 


Ala Asp Trp Phe Phe Pro Gly Glu Ile Glu Phe Asn Ile Thr Gly Asn 
                245                 250                 255     


Tyr Gly Ser Pro Val His Val Asn His Asn Ala Asn Tyr Ser Ser Met 
            260                 265                 270         


Pro Ser Pro Asp Met Asp Pro Ala Asp Arg Arg Gln Pro Glu Gln Ala 
        275                 280                 285             


Arg Arg Pro Leu Ser Val Ala Thr Asp Asn Met Met Leu Glu Phe Tyr 
    290                 295                 300                 


Lys Lys Asp Gly Met Gly Val Arg Val Met Asp Thr Asn Trp Val Ala 
305                 310                 315                 320 


Arg Arg Gly Ser Ser Ala Gly Arg Lys Val Ser Cys Ala Pro Pro Ser 
                325                 330                 335     


Met Gln Pro Pro Ala Pro Pro Ala Glu Leu Ala Ala Pro Leu Pro Ser 
            340                 345                 350         


Pro Leu Pro Glu Gln Pro Leu Asp Ser Pro Ala Ala Pro Ala Leu Ser 
        355                 360                 365             


Pro Ser Gly Leu Gly Leu Gln Pro Gly Pro Glu Arg Thr Ser Thr Thr 
    370                 375                 380                 


Lys Ser Lys Glu Leu Ser Pro Gly Ser Ala Gln Lys Gly Ser Pro Gly 
385                 390                 395                 400 


Ser Ser Gln Gly Thr Ala Cys Ala Gly Thr Gln Pro Gly Ala Gln Pro 
                405                 410                 415     


Gly Ala Gln Pro Gly Ala Ser Pro Ser Pro Ser Gln Pro Pro Ala Asp 
            420                 425                 430         


Gln Ser Pro His Thr Leu Arg Lys Val Ser Lys Lys Leu Ala Pro Ile 
        435                 440                 445             


Pro Pro Lys Val Pro Phe Gly Gln Pro Gly Ala Met Ala Asp Gln Ser 
    450                 455                 460                 


Ala Gly Gln Pro Ser Pro Val Ser Leu Ser Pro Thr Pro Pro Ser Thr 
465                 470                 475                 480 


Pro Ser Pro Tyr Gly Leu Ser Tyr Pro Gln Gly Tyr Ser Leu Ala Ser 
                485                 490                 495     


Gly Gln Leu Ser Pro Ala Ala Ala Pro Pro Leu Ala Ser Pro Ser Val 
            500                 505                 510         


Phe Thr Ser Thr Leu Ser Lys Ser Arg Pro Thr Pro Lys Pro Arg Gln 
        515                 520                 525             


Arg Pro Thr Leu Pro Pro Pro Gln Pro Pro Thr Val Asn Leu Ser Ala 
    530                 535                 540                 


Ser Ser Pro Gln Ser Thr Glu Ala Pro Met Leu Asp Gly Met Ser Pro 
545                 550                 555                 560 


Gly Glu Ser Met Ser Thr Ala Val 
                565             

<210>  3305
<211>  3997
<212>  DNA
<213>  Homo sapiens

<400>  3305
attccgcatt cctagcctgg cggcgcgcgc ggctccttaa tgagactcgg gccaagggcc     60

gacctcgcga ttccgctcgc ccctatttta tgtttgattt ttccttccca acgccggcta    120

gcgctgggac ccgaatgggg ccggccagct gcggcgggag gagcctccac ctccctcagc    180

tgcgtttctc cagggtagac gccaccgcag tcactgatgt cccttttcaa aggatgcacg    240

ctccccaccg ggcgccggag gtgttttgca gccgctcttc cagaggcgcg ggtagggggc    300

accctacccc cacccccaga gttcgctggg cactggctgg gaatcagcct cgctgctgtg    360

cccagctcct ctcgggccgc gggggctctg gggctcagct tcgtgcggga tgggtccggg    420

gcgcagctgt gggaaaccta tttattctgt tgctggggaa ggaagacgga gaagaggagg    480

ggacagtgct ttcctacagt agtatggtgc atatctccaa catcacaggc attgtaggta    540

caacagtgag caggacaaaa ccagctcttg tcctcatgga actaactttc tagaggggaa    600

ggcagacact aagcttctaa ttgcttgcaa ttgtggtgtg atttggcatc atgcacttcg    660

ctcatcttat ggagaagact gaggcctgtg gttggaaagg gcgagggagc agcctgctat    720

ctttagagaa cacagtttca gcctcaagtt cttcctgtac ctccgatatg gatctaccct    780

tcctggattg aagccttgtg ccaagtccat gggcctgatg atcctctgac tctccaaatg    840

ccagattttc ctcctccttg cctcagggaa gtgaagggca gccgatagcc cacctggaga    900

ataaaatatg actacaacct gcagtgctcc atggacctgt cattctcagc agtgtaaatc    960

ctactgctca gagagaaggc agttggcaca aggtagacag ccagttgttt cagctattcc   1020

aatcctgcat gtcatttacc tggaaagggg ttctatacat tccctctgcc tttcctacta   1080

ccccagcaga ctgccctcgg tctcacctgt tagtcctagt tacggattcc caaacagcaa   1140

tgccactgga gcttagataa ggggaagtca gaggagccac cccaactgga gcccgggctg   1200

gagagaggac ctggcatgtg tgtactcttc tatcccagat gagcacctta tcaacttaag   1260

gtggtagtgt ctctgctgtt tccattctgt ttgtgtcttc tggacagagg attggcaatg   1320

gttggaggtt atctcagtca ccagttccca ggtgatgcct ggaagaaccc tgtcctcctg   1380

ccaagaagcc aggcagcaag tggggttctg tcccaggccc cggtgcccta catggatgct   1440

tatcaaggac ccatacataa actggcaccc acttcctccc atgcctgacc tgccctcatg   1500

ataggccagg tgacatctgt ccttcagcat gcctctgttt ttcagaatgt ctaccatcag   1560

gagacaatca gatgagccaa tgtggagcat catgaagaca tgttcctggg atcatcctgg   1620

aatccgactc tgtctcagct caagggggtt ccgagatttc ctaagctagc cctctcattt   1680

tacagctgca aaaacggagg cctgttaatt cagtcatttt atgaaatcct ttgaaatttt   1740

tattgagctc taattgtgtg tgaagtatta tggaatgctt ctgtactgga atgcataggt   1800

tgaacaagac agaaaggccc agatggcaga agttcaagag ctttcaccaa cccatataga   1860

gaacctagta atattaatga ctaatgttaa tgaatccatg ctttttacgt gccagtcact   1920

gtgcccagca ttttgcatgc attatctgag tcctcactac aacgctgtta cgtaggtact   1980

gttattataa ccattttcca gatgagaaaa ctgaggctca gtgaaggcaa gtttcttgcc   2040

tagggtcata gagctataaa gtagcagagt cacagctcaa aagcacatat atgtgattcc   2100

aaagctcaga tacgtaaccc atttagccac tttcactgtg atatgcaagg gcccaggatt   2160

tcatatatag caaagctatc atttctgggt ggacatgttt aggggcagtg gggtaccagg   2220

cataaatagg ctgttcaaca cggggagggc agtgtgtgaa ggaggccagc acaggggctc   2280

tgggaacaca ggcacctctg atgagaaagt agtgttcttt ctgcagtact gttctgagta   2340

gctcagcctc ttgttcccct tccccagcac ccagattcac acctacatgc tgttagacat   2400

tcaccccatt tagtacacag ttatgcatac acgtggctat tgtagcaatt gtcgaacttt   2460

caccctgcag ctgggctgct ttgccttccc ctgtaggctg agctcccagc ttagattcca   2520

gcaccaatag ctatttgtgg gacaggagaa tgtcagcagt gaagggcagc atgatggcca   2580

gcatgtggct ttcccaagca gagacctggg ttccagtcct agaaggcaag gcaactgtat   2640

tagtttgctc atgctgctgt gacaaaatac tacagaccaa atggcttaaa cgacagaagt   2700

ttttttttct caccgttctg gaggctggag tccaagatca gcgtgctggc agggttggtt   2760

tccccttagg actctttcct tagctagaag atggacacct tcttgctatg ttttcacata   2820

cggtcatttt tctgtgttca tgaatcatgg tttatcttcc tcttcttata aggacgctag   2880

tcatattgga tttgggcccc atgaaaatgg ttcattttaa cttactcacc tctttaaaga   2940

cgttagctcc aaagattgtt gtatgctgag ttacttgggg ttggaacttc aacgtatgaa   3000

ttttggaggt agaagatata tttgagagta aaaaggggtt ctgttaaccc atttatgcct   3060

gaggttgcaa ttttttgaag ttttgcaatc agatcttggc aatgacctgg agcggtagga   3120

tataaataat tcccacatgc ttagcattcc aataatggaa cactaggcat aaatgggcta   3180

aaaattactt tggagcagca gtcttaaatg gaccatttag ggcaaactgg aacatatgga   3240

caccctaaca ttctggcccc atcactcact ctacagccat cttcttttaa accactgcac   3300

ctctctgagt ctcagtttct tcatctgttg aatggagata atcatatcaa ctcccccaag   3360

caggcacttt taaaatacta gtaaatgcat actgattacc tgacagtact gagcaccact   3420

gcatgctctg taaaggttaa ccattgctat tattgaaacc aaactgctca ctgaggtcta   3480

tgggcctatg tgatttgacc cctagctgct tttccaaatt catttcttcc cccttccccc   3540

ttctcccttc tattttatta cactggcacc acaaaggccg cccagcagtc atatatcaag   3600

cacattcctg cctcagggcc tttgtacctg ttgttccctc cacctggaat gttttcccct   3660

aaccccttgc tcctttactt cattcaggtt tttgcccaac tgccacttcc tcagagatac   3720

cttccgagat atatgatgag ctgatataaa ataatgcaac tattgttcta cctccattgc   3780

tttattcttt tatgctactt taattggatt catagcagtt ggtattttat tttagaattg   3840

cctgtgtatc tatctgtctc ttctgataga atgtaagctc cccaagggcc aagattctgt   3900

atgaaccatt caccaacgta tccccagtgc ccagaatggt gcctggcata tgtgcttaac   3960

aaaataaact gactggatta tttatccata ttcactt                            3997


<210>  3306
<211>  167
<212>  PRT
<213>  Homo sapiens

<400>  3306


Met Phe Asp Phe Ser Phe Pro Thr Pro Ala Ser Ala Gly Thr Arg Met 
1               5                   10                  15      


Gly Pro Ala Ser Cys Gly Gly Arg Ser Leu His Leu Pro Gln Leu Arg 
            20                  25                  30          


Phe Ser Arg Val Asp Ala Thr Ala Val Thr Asp Val Pro Phe Gln Arg 
        35                  40                  45              


Met His Ala Pro His Arg Ala Pro Glu Val Phe Cys Ser Arg Ser Ser 
    50                  55                  60                  


Arg Gly Ala Gly Arg Gly His Pro Thr Pro Thr Pro Arg Val Arg Trp 
65                  70                  75                  80  


Ala Leu Ala Gly Asn Gln Pro Arg Cys Cys Ala Gln Leu Leu Ser Gly 
                85                  90                  95      


Arg Gly Gly Ser Gly Ala Gln Leu Arg Ala Gly Trp Val Arg Gly Ala 
            100                 105                 110         


Ala Val Gly Asn Leu Phe Ile Leu Leu Leu Gly Lys Glu Asp Gly Glu 
        115                 120                 125             


Glu Glu Gly Thr Val Leu Ser Tyr Ser Ser Met Val His Ile Ser Asn 
    130                 135                 140                 


Ile Thr Gly Ile Val Gly Thr Thr Val Ser Arg Thr Lys Pro Ala Leu 
145                 150                 155                 160 


Val Leu Met Glu Leu Thr Phe 
                165         

<210>  3307
<211>  4374
<212>  DNA
<213>  Homo sapiens

<400>  3307
cccccgggac gcccgcggcc accgggctcc ggactgcacg tgcagctccc cccgcgcctc     60

gcagatcctg cagggggcac cagctggggg aggtggaggc tcctcccgcc cggagctgcg    120

cccccaccgg ctccgagggt gtagccgcca gcgcctggga cgccccctcc ccgcaaagtg    180

tccccgaatt gcactctctg gtcccggagc tgcatctgag acagccgggc gccacggcag    240

ccctgagttg gatgtgacca agcccagcct ggggccaagt cgtcgtcgac tgttgctctc    300

tcggacccct cccgcccccg cctcggccat ggccccgggg atgtcgggcc gcggcggcgc    360

cgccctgctc tgcctctcag cgctactcgc ccacgcctct ggccgctccc acccggccag    420

ccccagcccg ccggggccgc aggccagccc ggtgctgcca gtcagctacc gcctgtcgca    480

cacgcggctg gccttcttcc tgcgggaggc gcggcccccg tcacccgcgg tcgccaacag    540

ctctctgcag cgctccgagc ccttcgtggt gttccagacc aaggagctgc cggtcctcaa    600

cgtctctctg gggcccttca gcaccagcca ggtggtggcg cgggagctcc tgcagccgtc    660

cagcaccctg gacatccccg agcgcctgac ggtgaactgg aaggtgcggg ccttcatcgt    720

ccgctcgcac gtgcccgcct cgcagcccgt ggtccaggtg ctgttctacg tagccggccg    780

ggactgggac gacttcggcg tcaccgagcg gctgccctgt gtccgcctgc atgccttccg    840

ggatgcccgg gaacaccccc tgctgcgcat cgggagcatc agcctgttcc gcccgccccc    900

caggaggacc ctgcaggagc acaggctgga cagcaacctg atgatccgcc tgccagaccg    960

gcccctcaag cccggggaag tgctcagcat cctcctctat ctggccccca actcctcctc   1020

gccctccagc cccagcgtgg agcacttcac actcagggtg aaggccaaga agggtgtgac   1080

ccttttaggt accaagtcac ggagtggcca gtggcatgtg acctcggagc tgctgactgg   1140

ggcaaagcac tcaacagcca ccgtggatgt ggcctgggct cagagcacac ccctgccccc   1200

cagggagggc cagggcccct tggagatctt gcagctggac tttgaaatgg agaacttcac   1260

cagccagtca gtcaagcgga ggatcatgtg gcacattgac taccgtggcc acggcgccct   1320

gcctgacctg gagcgggcag tcactgagct gacggtcatt cagcgggatg tgcaagccat   1380

cctgcccctg gccatggaca cagagatcat caacacggcc attctgactg gccggacagt   1440

ggccatccct gtcaaggtca ttgccatcga ggtgaatggc ctcgtcctgg acatctccgc   1500

cctagtggaa tgcgagtctg acaatgaaga catcatcaag gtatccagca gctgtgacta   1560

cgtgtttgtg agtggaaaag agtctcgagg gtccatgaac gccagggtca ccttccgcta   1620

cgacgtcctc aatgctcccc tggaaatgac agtctgggtc cccaagctgc ccttgcacat   1680

tgagctctca gatgcccgcc tcagccaagt gaagggctgg agggtaccta tcctccccga   1740

ccggaggtca gtccgggaaa gcgaggatga ggatgaggag gaggaggagc ggcggcagag   1800

tgcaagccgt ggctgcaccc tgcagtacca gcatgccacc ctgcaggtct tcacccagtt   1860

ccacacgaca tcatccgagg gcactgacca ggtggtcacc atgttaggcc cggactggct   1920

ggtggaggtc accgacctag tcagtgactt catgcgggtg ggcgatcccc gagtggcaca   1980

catggtggac agcagcacgc tggcaggact ggagccaggc accaccccct ttaaggtggt   2040

gtctccgctg acggaggctg tgctcgggga gacgctgctg acggtgactg aggagaaggt   2100

cagcatcaca cagcttcagg cccaggtggt ggccagcctg gccctctccc tgcggcccag   2160

ccctgggagc agccacacca tcctagccac cacagctgcc caacagacct tgagcttcct   2220

caagcaggaa gccctactga gcctctggct ctcctacagt gatggcacca cagccccact   2280

ctccctctac agcccacgag actatggact gctagtgagc agcctggatg agcatgtggc   2340

cactgtgacc caggaccggg ccttccctct ggtagtggct gaggccgagg ggtcagggga   2400

gctgcttcgc gcagagctaa ccatcgctga gagctgccag aaaaccaaac gcaagagtgt   2460

gctcgccacg acccctgtgg gcctgcgggt gcactttggg agggacgagg aggaccccac   2520

ttatgactac ccgggcccca gccaaccagg gcccggcggg ggcgaggacg aggcccgggg   2580

agctggcccg ccgggctctg cgctacccgc accggaggct ccaggcccgg gcaccgccag   2640

ccccgtcgtg ccacccacag aagacttcct gccgctgccc accggcttcc tgcaggtgcc   2700

acggggtctg acagacctgg agatcggcat gtacgcgctg ctgggcgtct tctgcctcgc   2760

catcctcgtc ttcctcatca actgcatcgt ttttgtgctg cgctaccggc acaagcgcat   2820

cccgcccgag ggccagacca gcatggacca ctctcaccac tgggtgttcc tgggcaacgg   2880

gcagccgctg cgggtgcaag gagagctgtc gccgccagca ggcaacccgc tggaaaccgt   2940

gcccgccttc tgccacggcg accaccacag cagcggcagc tcgcagacca gcgtccagag   3000

ccaggtgcac ggcaggggcg acggctcctc gggcggctca gcccgagacc aagccgagga   3060

ccccgccagc tcgcccacct ccaagcgcaa gcgggtcaag ttcaccacct tcaccacgct   3120

gccgtcagag gagctggcct atgactcggt gcccgcgggc gaagaggacg aggaggagga   3180

agaggacctg ggttggggct gcccggatgt ggcgggcccc acgcggccca ctgcaccccc   3240

ggacctgcac aattacatgc gcagaatcaa agagattgca tagaggcgcc agccggagta   3300

gcagggaccc ccccccccaa cggggtcagc tcggggtagg acacagccgg gaccccggtt   3360

cacactgact ctgggcggct gaattgattt tgtactccct gcccctgcag cttggctccg   3420

tgcggagcgg gccgcctcag tgtctgggcc ttccctcgcc tcacgccatt accctcttct   3480

gccccctgca ggtggagggc tcttcctcca gtggctcgta aggaggaaag caaccccagc   3540

ctctgttctg ccctttccaa acctcctccc atcttaagca accccctgcc ccaagagtga   3600

ggcaaggagg tccagcttgg ggtcaggtgg gcccacgctg tgtcccgggc ccgcctcccg   3660

tcccccgtgt cgtccccctg tgcagggggt tctgtggggg tcttgtgtca caggctgcac   3720

aaagactttc ctcaaactaa tattcaggga tttctgtcct gcagggtggg gaggtggcag   3780

ctgcctgccc tgccaaggat cttgctgtgg acgaaatatc tgggggttag ggggacagtt   3840

gtagcatctg ctggcattcg ggtgcctccc aggacctggg agctgactct acagagaggt   3900

ctggtgccaa gccaggcacc ttcctgagtt ctcaggactc ccacctctgc cccaagggct   3960

ttgggcaggg acctaaaggg gaaagagtcc tggatccatc tctagccaaa tcacacccca   4020

gagccagagg cctggggacc tccttgcctt ccccgtcccc cacagcaagg tcaacactac   4080

tacgccttag ccacccgtca ccctgctgac tgcgacttcc ctctgcagca cagggcaggc   4140

agccacctat gccccacaag acggaacccg ggaggggagt agagggcacc agggaatgct   4200

gtgagggact tcagggtggg caaatgcaga agggagccag tgtcgcccct accccatccc   4260

acagccattt ttctctcggg ttctacccac cactgtgtcg gatttttctt aaataaatgg   4320

aagcggtcag actggaggtg ggggcagcag ctcccatgaa cagagagtac atgg         4374


<210>  3308
<211>  984
<212>  PRT
<213>  Homo sapiens

<400>  3308


Met Ala Pro Gly Met Ser Gly Arg Gly Gly Ala Ala Leu Leu Cys Leu 
1               5                   10                  15      


Ser Ala Leu Leu Ala His Ala Ser Gly Arg Ser His Pro Ala Ser Pro 
            20                  25                  30          


Ser Pro Pro Gly Pro Gln Ala Ser Pro Val Leu Pro Val Ser Tyr Arg 
        35                  40                  45              


Leu Ser His Thr Arg Leu Ala Phe Phe Leu Arg Glu Ala Arg Pro Pro 
    50                  55                  60                  


Ser Pro Ala Val Ala Asn Ser Ser Leu Gln Arg Ser Glu Pro Phe Val 
65                  70                  75                  80  


Val Phe Gln Thr Lys Glu Leu Pro Val Leu Asn Val Ser Leu Gly Pro 
                85                  90                  95      


Phe Ser Thr Ser Gln Val Val Ala Arg Glu Leu Leu Gln Pro Ser Ser 
            100                 105                 110         


Thr Leu Asp Ile Pro Glu Arg Leu Thr Val Asn Trp Lys Val Arg Ala 
        115                 120                 125             


Phe Ile Val Arg Ser His Val Pro Ala Ser Gln Pro Val Val Gln Val 
    130                 135                 140                 


Leu Phe Tyr Val Ala Gly Arg Asp Trp Asp Asp Phe Gly Val Thr Glu 
145                 150                 155                 160 


Arg Leu Pro Cys Val Arg Leu His Ala Phe Arg Asp Ala Arg Glu His 
                165                 170                 175     


Pro Leu Leu Arg Ile Gly Ser Ile Ser Leu Phe Arg Pro Pro Pro Arg 
            180                 185                 190         


Arg Thr Leu Gln Glu His Arg Leu Asp Ser Asn Leu Met Ile Arg Leu 
        195                 200                 205             


Pro Asp Arg Pro Leu Lys Pro Gly Glu Val Leu Ser Ile Leu Leu Tyr 
    210                 215                 220                 


Leu Ala Pro Asn Ser Ser Ser Pro Ser Ser Pro Ser Val Glu His Phe 
225                 230                 235                 240 


Thr Leu Arg Val Lys Ala Lys Lys Gly Val Thr Leu Leu Gly Thr Lys 
                245                 250                 255     


Ser Arg Ser Gly Gln Trp His Val Thr Ser Glu Leu Leu Thr Gly Ala 
            260                 265                 270         


Lys His Ser Thr Ala Thr Val Asp Val Ala Trp Ala Gln Ser Thr Pro 
        275                 280                 285             


Leu Pro Pro Arg Glu Gly Gln Gly Pro Leu Glu Ile Leu Gln Leu Asp 
    290                 295                 300                 


Phe Glu Met Glu Asn Phe Thr Ser Gln Ser Val Lys Arg Arg Ile Met 
305                 310                 315                 320 


Trp His Ile Asp Tyr Arg Gly His Gly Ala Leu Pro Asp Leu Glu Arg 
                325                 330                 335     


Ala Val Thr Glu Leu Thr Val Ile Gln Arg Asp Val Gln Ala Ile Leu 
            340                 345                 350         


Pro Leu Ala Met Asp Thr Glu Ile Ile Asn Thr Ala Ile Leu Thr Gly 
        355                 360                 365             


Arg Thr Val Ala Ile Pro Val Lys Val Ile Ala Ile Glu Val Asn Gly 
    370                 375                 380                 


Leu Val Leu Asp Ile Ser Ala Leu Val Glu Cys Glu Ser Asp Asn Glu 
385                 390                 395                 400 


Asp Ile Ile Lys Val Ser Ser Ser Cys Asp Tyr Val Phe Val Ser Gly 
                405                 410                 415     


Lys Glu Ser Arg Gly Ser Met Asn Ala Arg Val Thr Phe Arg Tyr Asp 
            420                 425                 430         


Val Leu Asn Ala Pro Leu Glu Met Thr Val Trp Val Pro Lys Leu Pro 
        435                 440                 445             


Leu His Ile Glu Leu Ser Asp Ala Arg Leu Ser Gln Val Lys Gly Trp 
    450                 455                 460                 


Arg Val Pro Ile Leu Pro Asp Arg Arg Ser Val Arg Glu Ser Glu Asp 
465                 470                 475                 480 


Glu Asp Glu Glu Glu Glu Glu Arg Arg Gln Ser Ala Ser Arg Gly Cys 
                485                 490                 495     


Thr Leu Gln Tyr Gln His Ala Thr Leu Gln Val Phe Thr Gln Phe His 
            500                 505                 510         


Thr Thr Ser Ser Glu Gly Thr Asp Gln Val Val Thr Met Leu Gly Pro 
        515                 520                 525             


Asp Trp Leu Val Glu Val Thr Asp Leu Val Ser Asp Phe Met Arg Val 
    530                 535                 540                 


Gly Asp Pro Arg Val Ala His Met Val Asp Ser Ser Thr Leu Ala Gly 
545                 550                 555                 560 


Leu Glu Pro Gly Thr Thr Pro Phe Lys Val Val Ser Pro Leu Thr Glu 
                565                 570                 575     


Ala Val Leu Gly Glu Thr Leu Leu Thr Val Thr Glu Glu Lys Val Ser 
            580                 585                 590         


Ile Thr Gln Leu Gln Ala Gln Val Val Ala Ser Leu Ala Leu Ser Leu 
        595                 600                 605             


Arg Pro Ser Pro Gly Ser Ser His Thr Ile Leu Ala Thr Thr Ala Ala 
    610                 615                 620                 


Gln Gln Thr Leu Ser Phe Leu Lys Gln Glu Ala Leu Leu Ser Leu Trp 
625                 630                 635                 640 


Leu Ser Tyr Ser Asp Gly Thr Thr Ala Pro Leu Ser Leu Tyr Ser Pro 
                645                 650                 655     


Arg Asp Tyr Gly Leu Leu Val Ser Ser Leu Asp Glu His Val Ala Thr 
            660                 665                 670         


Val Thr Gln Asp Arg Ala Phe Pro Leu Val Val Ala Glu Ala Glu Gly 
        675                 680                 685             


Ser Gly Glu Leu Leu Arg Ala Glu Leu Thr Ile Ala Glu Ser Cys Gln 
    690                 695                 700                 


Lys Thr Lys Arg Lys Ser Val Leu Ala Thr Thr Pro Val Gly Leu Arg 
705                 710                 715                 720 


Val His Phe Gly Arg Asp Glu Glu Asp Pro Thr Tyr Asp Tyr Pro Gly 
                725                 730                 735     


Pro Ser Gln Pro Gly Pro Gly Gly Gly Glu Asp Glu Ala Arg Gly Ala 
            740                 745                 750         


Gly Pro Pro Gly Ser Ala Leu Pro Ala Pro Glu Ala Pro Gly Pro Gly 
        755                 760                 765             


Thr Ala Ser Pro Val Val Pro Pro Thr Glu Asp Phe Leu Pro Leu Pro 
    770                 775                 780                 


Thr Gly Phe Leu Gln Val Pro Arg Gly Leu Thr Asp Leu Glu Ile Gly 
785                 790                 795                 800 


Met Tyr Ala Leu Leu Gly Val Phe Cys Leu Ala Ile Leu Val Phe Leu 
                805                 810                 815     


Ile Asn Cys Ile Val Phe Val Leu Arg Tyr Arg His Lys Arg Ile Pro 
            820                 825                 830         


Pro Glu Gly Gln Thr Ser Met Asp His Ser His His Trp Val Phe Leu 
        835                 840                 845             


Gly Asn Gly Gln Pro Leu Arg Val Gln Gly Glu Leu Ser Pro Pro Ala 
    850                 855                 860                 


Gly Asn Pro Leu Glu Thr Val Pro Ala Phe Cys His Gly Asp His His 
865                 870                 875                 880 


Ser Ser Gly Ser Ser Gln Thr Ser Val Gln Ser Gln Val His Gly Arg 
                885                 890                 895     


Gly Asp Gly Ser Ser Gly Gly Ser Ala Arg Asp Gln Ala Glu Asp Pro 
            900                 905                 910         


Ala Ser Ser Pro Thr Ser Lys Arg Lys Arg Val Lys Phe Thr Thr Phe 
        915                 920                 925             


Thr Thr Leu Pro Ser Glu Glu Leu Ala Tyr Asp Ser Val Pro Ala Gly 
    930                 935                 940                 


Glu Glu Asp Glu Glu Glu Glu Glu Asp Leu Gly Trp Gly Cys Pro Asp 
945                 950                 955                 960 


Val Ala Gly Pro Thr Arg Pro Thr Ala Pro Pro Asp Leu His Asn Tyr 
                965                 970                 975     


Met Arg Arg Ile Lys Glu Ile Ala 
            980                 

<210>  3309
<211>  1190
<212>  DNA
<213>  Homo sapiens

<400>  3309
attccaggtg accaaactgg gaagaaagct atcagcacca actcagaact ctccaccttc     60

agatcagaca tacagatata taggccaact attagtaata atatgaaata tacttaaaga    120

gcttttaaaa ctttgtattt ttgtacaaaa tatttgtctt ttacaatttt tttccttttt    180

ttttttttgt cattttaccg acataataca tggagccaaa gaaaacaata atggtactaa    240

taaaaactcc tagggtttcc tgtcagattt aattctaccc agtggcaaag aattttttca    300

attgtggctt taaaaaaata attaaatata catgtgtata tatatatata tatatatatt    360

tttttttttt ttttttttta atgtttcatt tcctcagagg aaccaatcac ttggaatgtc    420

tagaaatatc cttgcagatt ttgccagtgt caatcaagcc tgcacacatg cacagtgaag    480

cgggctgtgc ctgccttgag cccatcacca gccaacattc ttgacgtgtg cctgaccaga    540

cacagaagaa atgggcaact caagacgtgc ttccacttca ttttggtgga gtcgggaggt    600

gtgggggatg gagaggcatc tgttgggaag ggcactgaat ctggcctatc tggaaggccc    660

tgtgtcatgg ctgagctatg actgtacttg gcatcagatc cctacagagc caacattaac    720

tgtcaggaac gtatggcgtc acatcagcca aaggcagaga tgctagaaag atgggaaccg    780

gctacgtgtt acctggaaag tttgttttct taagtcatat tccaaaaaca taactccaag    840

gcatacgcat gataaaatgc aagaataaac ttttggccac tttgtggaac tcttaaaaga    900

acctttccag ccgggcgcag tggctcatgc ctgtaatccc agcactttgg gaggccgagg    960

caggcagatg acttgaggtc aggagttcga gaccagcctg gccaacgtgg caaaacccca   1020

tctctactaa aaataagaaa attagccggg tgtagtggca catgcctgta atcccagcta   1080

ctcaggaggc tgaggcagga gaatcgcttg agcccaggag gcagagattg cagtgagcca   1140

agatcgcacc actgcactcc agcctcggtg acagagcaag actccatctc              1190


<210>  3310
<211>  71
<212>  PRT
<213>  Homo sapiens

<400>  3310


Met Gly Asn Ser Arg Arg Ala Ser Thr Ser Phe Trp Trp Ser Arg Glu 
1               5                   10                  15      


Val Trp Gly Met Glu Arg His Leu Leu Gly Arg Ala Leu Asn Leu Ala 
            20                  25                  30          


Tyr Leu Glu Gly Pro Val Ser Trp Leu Ser Tyr Asp Cys Thr Trp His 
        35                  40                  45              


Gln Ile Pro Thr Glu Pro Thr Leu Thr Val Arg Asn Val Trp Arg His 
    50                  55                  60                  


Ile Ser Gln Arg Gln Arg Cys 
65                  70      

<210>  3311
<211>  3853
<212>  DNA
<213>  Homo sapiens

<400>  3311
cgcgcgcggc agccccgagg cagcagagcg cggagccggg ataccatggg cgtgcggtga     60

gcagccgctc gggacgactt cctcggctgc gcggcgctcg cgcggagctc cccggccggc    120

ggtgcgtccc cacggtcacc atgaaagggt attcaggaag gaacacaatg taccaaatgt    180

aaaaataact gggcactgaa gttttctatc atattattat acattttgtg tgccttgcta    240

acaatcacag tagccatttt gggatataaa gttgtagaga aaatggacaa tgtcacaggt    300

ggcatggaaa catctcgcca aacctatgat gacaagctca cagcagtgga aagtgacctg    360

aaaaaattag gtgaccaaac tgggaagaaa gctatcagca ccaactcaga actctccacc    420

ttcagatcag acattctaga tctccgtcag caacttcgtg agattacaga aaaaaccagc    480

aagaacaagg atacgctgga gaagttacag gcgagcgggg atgctctggt ggacaggcag    540

agtcaattga aagaaacttt ggagaataac tctttcctca tcaccactgt aaacaaaacc    600

ctccaggcgt ataatggcta tgtcacgaat ctgcagcaag ataccagcgt gctccagggc    660

aatctgcaga accaaatgta ttctcataat gtggtcatca tgaacctcaa caacctgaac    720

ctgacccagg tgcagcagag gaacctcatc acgaatctgc agcggtctgt ggatgacaca    780

agccaggcta tccagcgaat caagaacgac tttcaaaatc tgcagcaggt ttttcttcaa    840

gccaagaagg acacggattg gctgaaggag aaagtgcaga gcttgcagac gctggctgcc    900

aacaactctg cgttggccaa agccaacaac gacaccctgg aggatatgaa cagccagctc    960

aactcattca caggtcagat ggagaacatc accactatct ctcaagccaa cgagcagaac   1020

ctgaaagacc tgcaggactt acacaaagat gcagagaata gaacagccat caagttcaac   1080

caactggagg aacgcttcca gctctttgag acggatattg tgaacatcat tagcaatatc   1140

agttacacag cccaccacct gcggacgctg accagcaatc taaatgaagt caggaccact   1200

tgcacagata cccttaccaa acacacagat gatctgacct ccttgaataa taccctggcc   1260

aacatccgtt tggattctgt ttctctcagg atgcaacaag atttgatgag gtcgaggtta   1320

gacactgaag tagccaactt atcagtgatt atggaagaaa tgaagctagt agactccaag   1380

catggtcagc tcatcaagaa ttttacaata ctacaaggtc caccgggccc caggggtcca   1440

agaggtgaca gaggatccca gggaccccct ggcccaactg gcaacaaggg acagaaagga   1500

gagaaggggg agcctggacc acctggccct gcgggtgaga gaggcccaat tggaccagct   1560

ggtccccccg gagagcgtgg cggcaaagga tctaaaggct cccagggccc caaaggctcc   1620

cgtggttccc ctgggaagcc cggccctcag ggctccagtg gggacccagg ccccccgggc   1680

ccaccaggca aagagggact ccccggccct cagggccctc ctggcttcca gggacttcag   1740

ggcaccgttg gggagcctgg ggtgcctgga cctcggggac tgccaggctt gcctggggta   1800

ccaggcatgc caggccccaa gggccccccc ggccctcctg gcccatcagg agcggtggtg   1860

cccctggccc tgcagaatga gccaacccca gcaccggagg acaatggctg cccgcctcac   1920

tggaagaact tcacagacaa atgctactat ttttcagttg agaaagaaat ttttgaggat   1980

gcaaagcttt tctgtgaaga caagtcttca catcttgttt tcataaacac tagagaggaa   2040

cagcaatgga taaaaaaaca gatggtaggg agagagagcc actggatcgg cctcacagac   2100

tcagagcgtg aaaatgaatg gaagtggctg gatgggacat ctccagacta caaaaattgg   2160

aaagctggac agccggataa ctggggtcat ggccatgggc caggagaaga ctgtgctggg   2220

ttgatttatg ctgggcagtg gaacgatttc caatgtgaag acgtcaataa cttcatttgc   2280

gaaaaagaca gggagacagt actgtcatct gcattataac ggactgtgat gggatcacat   2340

gagcaaattt tcagctctca aaggcaaagg acactccttt ctaattgcat caccttctca   2400

tcagattgaa aaaaaaaaag cactgaaaac caattactga aaaaaaattg acagctagtg   2460

ttttttacca tccgtcatta cccaaagact tgggaactaa aatgttcccc agggtgatat   2520

gctgattttc attgtgcaca tggactgaat cacatagatt ctcctccgtc agtaaccgtg   2580

cgattataca aattatgtct tccaaagtat ggaacactcc aatcagaaaa aggttatcat   2640

tggtcgttga gttatgggaa gaacttaagc atatactgtg taaacagtgc catacatttc   2700

taaaatccca agtgtaggaa aaatatgcag acatacagat atataggcca actattagta   2760

ataatatgaa atatacttaa agagctttta aaactttgta tttttgtaca aaatatttgt   2820

cttttacaat ttttttcctt tttttttttt tgtcatttta ccgacataat acatggagcc   2880

aaagaaaaca ataatggtac taataaaaac tcctagggtt tcctgtcaga tttaattcta   2940

cccagtggca aagaattttt tcaattgtgg ctttaaaaaa ataattaaat atacatgtgt   3000

atatatatat atatatatat attttttttt tttttttttt ttaatgtttc atttcctcag   3060

aggaaccaat cacttggaat gtctagaaat atccttgcag attttgccag tgtcaatcaa   3120

gcctgcacac atgcacagtg aagcgggctg tgcctgcctt gagcccatca ccagccaaca   3180

ttcttgacgt gtgcctgacc agacacagaa gaaatgggca actcaagacg tgcttccact   3240

tcattttggt ggagtcggga ggtgtggggg atggagaggc atctgttggg aagggcactg   3300

aatctggcct atctggaagg ccctgtgtca tggctgagct atgactgtac ttggcatcag   3360

atccctacag agccaacatt aactgtcagg aacgtatggc gtcacatcag ccaaaggcag   3420

agatgctaga aagatgggaa ccggctacgt gttacctgga aagtttgttt tcttaagtca   3480

tattccaaaa acataactcc aaggcatacg catgataaaa tgcaagaata aacttttggc   3540

cactttgtgg aactcttaaa agaacctttc cagccgggcg cagtggctca tgcctgtaat   3600

cccagcactt tgggaggccg aggcaggcag atgacttgag gtcaggagtt cgagaccagc   3660

ctggccaacg tggcaaaacc ccatctctac taaaaataag aaaattagcc gggtgtagtg   3720

gcacatgcct gtaatcccag ctactcagga ggctgaggca ggagaatcgc ttgagcccag   3780

gaggcagaga ttgcagtgag ccaagatcgc accactgcac tccagcctcg gtgacagagc   3840

aagactccat ctc                                                      3853


<210>  3312
<211>  678
<212>  PRT
<213>  Homo sapiens

<400>  3312


Met Asp Asn Val Thr Gly Gly Met Glu Thr Ser Arg Gln Thr Tyr Asp 
1               5                   10                  15      


Asp Lys Leu Thr Ala Val Glu Ser Asp Leu Lys Lys Leu Gly Asp Gln 
            20                  25                  30          


Thr Gly Lys Lys Ala Ile Ser Thr Asn Ser Glu Leu Ser Thr Phe Arg 
        35                  40                  45              


Ser Asp Ile Leu Asp Leu Arg Gln Gln Leu Arg Glu Ile Thr Glu Lys 
    50                  55                  60                  


Thr Ser Lys Asn Lys Asp Thr Leu Glu Lys Leu Gln Ala Ser Gly Asp 
65                  70                  75                  80  


Ala Leu Val Asp Arg Gln Ser Gln Leu Lys Glu Thr Leu Glu Asn Asn 
                85                  90                  95      


Ser Phe Leu Ile Thr Thr Val Asn Lys Thr Leu Gln Ala Tyr Asn Gly 
            100                 105                 110         


Tyr Val Thr Asn Leu Gln Gln Asp Thr Ser Val Leu Gln Gly Asn Leu 
        115                 120                 125             


Gln Asn Gln Met Tyr Ser His Asn Val Val Ile Met Asn Leu Asn Asn 
    130                 135                 140                 


Leu Asn Leu Thr Gln Val Gln Gln Arg Asn Leu Ile Thr Asn Leu Gln 
145                 150                 155                 160 


Arg Ser Val Asp Asp Thr Ser Gln Ala Ile Gln Arg Ile Lys Asn Asp 
                165                 170                 175     


Phe Gln Asn Leu Gln Gln Val Phe Leu Gln Ala Lys Lys Asp Thr Asp 
            180                 185                 190         


Trp Leu Lys Glu Lys Val Gln Ser Leu Gln Thr Leu Ala Ala Asn Asn 
        195                 200                 205             


Ser Ala Leu Ala Lys Ala Asn Asn Asp Thr Leu Glu Asp Met Asn Ser 
    210                 215                 220                 


Gln Leu Asn Ser Phe Thr Gly Gln Met Glu Asn Ile Thr Thr Ile Ser 
225                 230                 235                 240 


Gln Ala Asn Glu Gln Asn Leu Lys Asp Leu Gln Asp Leu His Lys Asp 
                245                 250                 255     


Ala Glu Asn Arg Thr Ala Ile Lys Phe Asn Gln Leu Glu Glu Arg Phe 
            260                 265                 270         


Gln Leu Phe Glu Thr Asp Ile Val Asn Ile Ile Ser Asn Ile Ser Tyr 
        275                 280                 285             


Thr Ala His His Leu Arg Thr Leu Thr Ser Asn Leu Asn Glu Val Arg 
    290                 295                 300                 


Thr Thr Cys Thr Asp Thr Leu Thr Lys His Thr Asp Asp Leu Thr Ser 
305                 310                 315                 320 


Leu Asn Asn Thr Leu Ala Asn Ile Arg Leu Asp Ser Val Ser Leu Arg 
                325                 330                 335     


Met Gln Gln Asp Leu Met Arg Ser Arg Leu Asp Thr Glu Val Ala Asn 
            340                 345                 350         


Leu Ser Val Ile Met Glu Glu Met Lys Leu Val Asp Ser Lys His Gly 
        355                 360                 365             


Gln Leu Ile Lys Asn Phe Thr Ile Leu Gln Gly Pro Pro Gly Pro Arg 
    370                 375                 380                 


Gly Pro Arg Gly Asp Arg Gly Ser Gln Gly Pro Pro Gly Pro Thr Gly 
385                 390                 395                 400 


Asn Lys Gly Gln Lys Gly Glu Lys Gly Glu Pro Gly Pro Pro Gly Pro 
                405                 410                 415     


Ala Gly Glu Arg Gly Pro Ile Gly Pro Ala Gly Pro Pro Gly Glu Arg 
            420                 425                 430         


Gly Gly Lys Gly Ser Lys Gly Ser Gln Gly Pro Lys Gly Ser Arg Gly 
        435                 440                 445             


Ser Pro Gly Lys Pro Gly Pro Gln Gly Ser Ser Gly Asp Pro Gly Pro 
    450                 455                 460                 


Pro Gly Pro Pro Gly Lys Glu Gly Leu Pro Gly Pro Gln Gly Pro Pro 
465                 470                 475                 480 


Gly Phe Gln Gly Leu Gln Gly Thr Val Gly Glu Pro Gly Val Pro Gly 
                485                 490                 495     


Pro Arg Gly Leu Pro Gly Leu Pro Gly Val Pro Gly Met Pro Gly Pro 
            500                 505                 510         


Lys Gly Pro Pro Gly Pro Pro Gly Pro Ser Gly Ala Val Val Pro Leu 
        515                 520                 525             


Ala Leu Gln Asn Glu Pro Thr Pro Ala Pro Glu Asp Asn Gly Cys Pro 
    530                 535                 540                 


Pro His Trp Lys Asn Phe Thr Asp Lys Cys Tyr Tyr Phe Ser Val Glu 
545                 550                 555                 560 


Lys Glu Ile Phe Glu Asp Ala Lys Leu Phe Cys Glu Asp Lys Ser Ser 
                565                 570                 575     


His Leu Val Phe Ile Asn Thr Arg Glu Glu Gln Gln Trp Ile Lys Lys 
            580                 585                 590         


Gln Met Val Gly Arg Glu Ser His Trp Ile Gly Leu Thr Asp Ser Glu 
        595                 600                 605             


Arg Glu Asn Glu Trp Lys Trp Leu Asp Gly Thr Ser Pro Asp Tyr Lys 
    610                 615                 620                 


Asn Trp Lys Ala Gly Gln Pro Asp Asn Trp Gly His Gly His Gly Pro 
625                 630                 635                 640 


Gly Glu Asp Cys Ala Gly Leu Ile Tyr Ala Gly Gln Trp Asn Asp Phe 
                645                 650                 655     


Gln Cys Glu Asp Val Asn Asn Phe Ile Cys Glu Lys Asp Arg Glu Thr 
            660                 665                 670         


Val Leu Ser Ser Ala Leu 
        675             

<210>  3313
<211>  5577
<212>  DNA
<213>  Homo sapiens

<400>  3313
gagagcggcg cgcgcggcag ccccgaggca gcagagcgcg gagccgggag cgcggggagc     60

gcgggccggc ggcggcgagg gaggacgggg gcgcagacgg ccggcgcgcg gcgcggctac    120

catgggcgtg cggtgagcag ccgctcggga cgacttcctc ggctgcgcgg cgctcgcgcg    180

gagctccccg gccggcggtg cgtccccacg gtcaccatga aagacgactt cgcagaggag    240

gaggaggtgc aatccttcgg ttacaagcgg tttggtattc aggaaggaac acaatgtacc    300

aaatgtaaaa ataactgggc actgaagttt tctatcatat tattatacat tttgtgtgcc    360

ttgctaacaa tcacagtagc cattttggga tataaagttg tagagaaaat ggacaatgtc    420

acaggtggca tggaaacatc tcgccaaacc tatgatgaca agctcacagc agtggaaagt    480

gacctgaaaa aattaggtga ccaaactggg aagaaagcta tcagcaccaa ctcagaactc    540

tccaccttca gatcagacat tctagatctc cgtcagcaac ttcgtgagat tacagaaaaa    600

accagcaaga acaaggatac gctggagaag ttacaggcga gcggggatgc tctggtggac    660

aggcagagtc aattgaaaga aactttggag aataactctt tcctcatcac cactgtaaac    720

aaaaccctcc aggcgtataa tggctatgtc acgaatctgc agcaagatac cagcgtgctc    780

cagggcaatc tgcagaacca aatgtattct cataatgtgg tcatcatgaa cctcaacaac    840

ctgaacctga cccaggtgca gcagaggaac ctcatcacga atctgcagcg gtctgtggat    900

gacacaagcc aggctatcca gcgaatcaag aacgactttc aaaatctgca gcaggttttt    960

cttcaagcca agaaggacac ggattggctg aaggagaaag tgcagagctt gcagacgctg   1020

gctgccaaca actctgcgtt ggccaaagcc aacaacgaca ccctggagga tatgaacagc   1080

cagctcaact cattcacagg tcagatggag aacatcacca ctatctctca agccaacgag   1140

cagaacctga aagacctgca ggacttacac aaagatgcag agaatagaac agccatcaag   1200

ttcaaccaac tggaggaacg cttccagctc tttgagacgg atattgtgaa catcattagc   1260

aatatcagtt acacagccca ccacctgcgg acgctgacca gcaatctaaa tgaagtcagg   1320

accacttgca cagataccct taccaaacac acagatgatc tgacctcctt gaataatacc   1380

ctggccaaca tccgtttgga ttctgtttct ctcaggatgc aacaagattt gatgaggtcg   1440

aggttagaca ctgaagtagc caacttatca gtgattatgg aagaaatgaa gctagtagac   1500

tccaagcatg gtcagctcat caagaatttt acaatactac aaggtccacc gggccccagg   1560

ggtccaagag gtgacagagg atcccaggga ccccctggcc caactggcaa caagggacag   1620

aaaggagaga agggggagcc tggaccacct ggccctgcgg gtgagagagg cccaattgga   1680

ccagctggtc cccccggaga gcgtggcggc aaaggatcta aaggctccca gggccccaaa   1740

ggctcccgtg gttcccctgg gaagcccggc cctcagggct ccagtgggga cccaggcccc   1800

ccgggcccac caggcaaaga gggactcccc ggccctcagg gccctcctgg cttccaggga   1860

cttcagggca ccgttgggga gcctggggtg cctggacctc ggggactgcc aggcttgcct   1920

ggggtaccag gcatgccagg ccccaagggc ccccccggcc ctcctggccc atcaggagcg   1980

gtggtgcccc tggccctgca gaatgagcca accccagcac cggaggacaa tggtaagtcc   2040

aagccctccc tccagccagg gggacagggc agtgcatgtg cttgagactg agccaacccc   2100

cagtgtgtgg ccccacccat gttatttttg tttttgtttt tgttttgaga cagggtctca   2160

ctctgttgcc caggctggag tgcagtggcg tgatctcggc tcactgcaac ctccacatcc   2220

cgggttcaag tgattctcct gccttagcct cccaggtagc tgggactaca agcgtgtgcc   2280

cccacagcca gctaattttt gtatttttag tagagagggg gtttcaccgt gttggccagg   2340

ctggtctcaa actcctggcc tcaagtgatc cacctacctt agtctcccaa agtgctggga   2400

ttacaggtgt gagccaccac gtcttgtccc ccgctgcata ttatttaaca gcaaaggcat   2460

cataggggct ggcacaggag ccctgctgcc agaacaggcc tccataccag gcatgtgttt   2520

ctctctaaac gccattgggt tctctagtgc tcatttgttt tatgtattat gtgtgtatgt   2580

atgggacagg gtctcactct gtcacccagg ctggaatgac gaagtgaagt agtgcaaaca   2640

tagctcactg cagctttgac ctcctgggct taggtgatct tcccactcag actcctgcgt   2700

agctgggacc acaggggtat gccaccacac ctggctaatt ttttattttc ctttttgtag   2760

agacagggtc ttgctatgtt gcccaggctg gtcttgaact cctggcctca agcaaccctc   2820

ctgcctcagt cttgcaaagt gctgggattc caggtgggag ccactgcacc tggctcttgc   2880

acttgtttat ttataggagc cagccctcag aagacaaaca caatgcaaaa catttccttc   2940

agggaagcct gctggccgcc ctgagcgctc ttccctcgtt ttacatcctc actctggaga   3000

tagatgggct ccctcggtta gctccatcaa catgtggatg gaaccctctg ctattgatga   3060

ctacatttaa tttctttttg agaaaggtgt tagatgttac ggtgccttct agtcttttga   3120

taattaaacc tttggcaaaa ctcgaatgtt tggttagcaa ccaagcctat ttttctctcc   3180

tttgacccaa ccgctattct acttgatttt ggtcggtgag gcccgggtta tttttgttga   3240

tccgtgagcc cagttttggt gctgggttct cacatccaag tgttcctggg ttccgtatga   3300

ttccagactg acgctgaaca tctgtgcctg ccctgcttct tgttgttgct tctgttattt   3360

ctgtcattgt gaagacggat ccagacacag aagaacaaag acccagtcaa agatcttttc   3420

cagattatgt ggttttggct tgtgctctgc agtccacttt gggtcatgct tgctgcgagc   3480

acgtccgtga acgtcagctg tgggcctcgt gcagggacgc tcaggctgct cccagcggga   3540

ccacagtttt ggcctctgaa acacagctga agaaaggcag agtgctttct gtgatctttt   3600

aatcaatgtt ttccactttt gcattcctag gctgcccgcc tcactggaag aacttcacag   3660

acaaatgcta ctatttttca gttgagaaag aaatttttga ggatgcaaag cttttctgtg   3720

aagacaagtc ttcacatctt gttttcataa acactagaga ggaacagcaa tggataaaaa   3780

aacagatggt agggagagag agccactgga tcggcctcac agactcagag cgtgaaaatg   3840

aatggaagtg gctggatggg acatctccag actacaaaaa ttggaaagct ggacagccgg   3900

ataactgggg tcatggccat gggccaggag aagactgtgc tgggttgatt tatgctgggc   3960

agtggaacga tttccaatgt gaagacgtca ataacttcat ttgcgaaaaa gacagggaga   4020

cagtactgtc atctgcatta taacggactg tgatgggatc acatgagcaa attttcagct   4080

ctcaaaggca aaggacactc ctttctaatt gcatcacctt ctcatcagat tgaaaaaaaa   4140

aaagcactga aaaccaatta ctgaaaaaaa attgacagct agtgtttttt accatccgtc   4200

attacccaaa gacttgggaa ctaaaatgtt ccccagggtg atatgctgat tttcattgtg   4260

cacatggact gaatcacata gattctcctc cgtcagtaac cgtgcgatta tacaaattat   4320

gtcttccaaa gtatggaaca ctccaatcag aaaaaggtta tcattggtcg ttgagttatg   4380

ggaagaactt aagcatatac tgtgtaaaca gtgccataca tttctaaaat cccaagtgta   4440

ggaaaaatat gcagacatac agatatatag gccaactatt agtaataata tgaaatatac   4500

ttaaagagct tttaaaactt tgtatttttg tacaaaatat ttgtctttta caattttttt   4560

cctttttttt tttttgtcat tttaccgaca taatacatgg agccaaagaa aacaataatg   4620

gtactaataa aaactcctag ggtttcctgt cagatttaat tctacccagt ggcaaagaat   4680

tttttcaatt gtggctttaa aaaaataatt aaatatacat gtgtatatat atatatatat   4740

atatattttt tttttttttt ttttttaatg tttcatttcc tcagaggaac caatcacttg   4800

gaatgtctag aaatatcctt gcagattttg ccagtgtcaa tcaagcctgc acacatgcac   4860

agtgaagcgg gctgtgcctg ccttgagccc atcaccagcc aacattcttg acgtgtgcct   4920

gaccagacac agaagaaatg ggcaactcaa gacgtgcttc cacttcattt tggtggagtc   4980

gggaggtgtg ggggatggag aggcatctgt tgggaagggc actgaatctg gcctatctgg   5040

aaggccctgt gtcatggctg agctatgact gtacttggca tcagatccct acagagccaa   5100

cattaactgt caggaacgta tggcgtcaca tcagccaaag gcagagatgc tagaaagatg   5160

ggaaccggct acgtgttacc tggaaagttt gttttcttaa gtcatattcc aaaaacataa   5220

ctccaaggca tacgcatgat aaaatgcaag aataaacttt tggccacttt gtggaactct   5280

taaaagaacc tttccagccg ggcgcagtgg ctcatgcctg taatcccagc actttgggag   5340

gccgaggcag gcagatgact tgaggtcagg agttcgagac cagcctggcc aacgtggcaa   5400

aaccccatct ctactaaaaa taagaaaatt agccgggtgt agtggcacat gcctgtaatc   5460

ccagctactc aggaggctga ggcaggagaa tcgcttgagc ccaggaggca gagattgcag   5520

tgagccaaga tcgcaccact gcactccagc ctcggtgaca gagcaagact ccatctc      5577


<210>  3314
<211>  622
<212>  PRT
<213>  Homo sapiens

<400>  3314


Met Lys Asp Asp Phe Ala Glu Glu Glu Glu Val Gln Ser Phe Gly Tyr 
1               5                   10                  15      


Lys Arg Phe Gly Ile Gln Glu Gly Thr Gln Cys Thr Lys Cys Lys Asn 
            20                  25                  30          


Asn Trp Ala Leu Lys Phe Ser Ile Ile Leu Leu Tyr Ile Leu Cys Ala 
        35                  40                  45              


Leu Leu Thr Ile Thr Val Ala Ile Leu Gly Tyr Lys Val Val Glu Lys 
    50                  55                  60                  


Met Asp Asn Val Thr Gly Gly Met Glu Thr Ser Arg Gln Thr Tyr Asp 
65                  70                  75                  80  


Asp Lys Leu Thr Ala Val Glu Ser Asp Leu Lys Lys Leu Gly Asp Gln 
                85                  90                  95      


Thr Gly Lys Lys Ala Ile Ser Thr Asn Ser Glu Leu Ser Thr Phe Arg 
            100                 105                 110         


Ser Asp Ile Leu Asp Leu Arg Gln Gln Leu Arg Glu Ile Thr Glu Lys 
        115                 120                 125             


Thr Ser Lys Asn Lys Asp Thr Leu Glu Lys Leu Gln Ala Ser Gly Asp 
    130                 135                 140                 


Ala Leu Val Asp Arg Gln Ser Gln Leu Lys Glu Thr Leu Glu Asn Asn 
145                 150                 155                 160 


Ser Phe Leu Ile Thr Thr Val Asn Lys Thr Leu Gln Ala Tyr Asn Gly 
                165                 170                 175     


Tyr Val Thr Asn Leu Gln Gln Asp Thr Ser Val Leu Gln Gly Asn Leu 
            180                 185                 190         


Gln Asn Gln Met Tyr Ser His Asn Val Val Ile Met Asn Leu Asn Asn 
        195                 200                 205             


Leu Asn Leu Thr Gln Val Gln Gln Arg Asn Leu Ile Thr Asn Leu Gln 
    210                 215                 220                 


Arg Ser Val Asp Asp Thr Ser Gln Ala Ile Gln Arg Ile Lys Asn Asp 
225                 230                 235                 240 


Phe Gln Asn Leu Gln Gln Val Phe Leu Gln Ala Lys Lys Asp Thr Asp 
                245                 250                 255     


Trp Leu Lys Glu Lys Val Gln Ser Leu Gln Thr Leu Ala Ala Asn Asn 
            260                 265                 270         


Ser Ala Leu Ala Lys Ala Asn Asn Asp Thr Leu Glu Asp Met Asn Ser 
        275                 280                 285             


Gln Leu Asn Ser Phe Thr Gly Gln Met Glu Asn Ile Thr Thr Ile Ser 
    290                 295                 300                 


Gln Ala Asn Glu Gln Asn Leu Lys Asp Leu Gln Asp Leu His Lys Asp 
305                 310                 315                 320 


Ala Glu Asn Arg Thr Ala Ile Lys Phe Asn Gln Leu Glu Glu Arg Phe 
                325                 330                 335     


Gln Leu Phe Glu Thr Asp Ile Val Asn Ile Ile Ser Asn Ile Ser Tyr 
            340                 345                 350         


Thr Ala His His Leu Arg Thr Leu Thr Ser Asn Leu Asn Glu Val Arg 
        355                 360                 365             


Thr Thr Cys Thr Asp Thr Leu Thr Lys His Thr Asp Asp Leu Thr Ser 
    370                 375                 380                 


Leu Asn Asn Thr Leu Ala Asn Ile Arg Leu Asp Ser Val Ser Leu Arg 
385                 390                 395                 400 


Met Gln Gln Asp Leu Met Arg Ser Arg Leu Asp Thr Glu Val Ala Asn 
                405                 410                 415     


Leu Ser Val Ile Met Glu Glu Met Lys Leu Val Asp Ser Lys His Gly 
            420                 425                 430         


Gln Leu Ile Lys Asn Phe Thr Ile Leu Gln Gly Pro Pro Gly Pro Arg 
        435                 440                 445             


Gly Pro Arg Gly Asp Arg Gly Ser Gln Gly Pro Pro Gly Pro Thr Gly 
    450                 455                 460                 


Asn Lys Gly Gln Lys Gly Glu Lys Gly Glu Pro Gly Pro Pro Gly Pro 
465                 470                 475                 480 


Ala Gly Glu Arg Gly Pro Ile Gly Pro Ala Gly Pro Pro Gly Glu Arg 
                485                 490                 495     


Gly Gly Lys Gly Ser Lys Gly Ser Gln Gly Pro Lys Gly Ser Arg Gly 
            500                 505                 510         


Ser Pro Gly Lys Pro Gly Pro Gln Gly Ser Ser Gly Asp Pro Gly Pro 
        515                 520                 525             


Pro Gly Pro Pro Gly Lys Glu Gly Leu Pro Gly Pro Gln Gly Pro Pro 
    530                 535                 540                 


Gly Phe Gln Gly Leu Gln Gly Thr Val Gly Glu Pro Gly Val Pro Gly 
545                 550                 555                 560 


Pro Arg Gly Leu Pro Gly Leu Pro Gly Val Pro Gly Met Pro Gly Pro 
                565                 570                 575     


Lys Gly Pro Pro Gly Pro Pro Gly Pro Ser Gly Ala Val Val Pro Leu 
            580                 585                 590         


Ala Leu Gln Asn Glu Pro Thr Pro Ala Pro Glu Asp Asn Gly Lys Ser 
        595                 600                 605             


Lys Pro Ser Leu Gln Pro Gly Gly Gln Gly Ser Ala Cys Ala 
    610                 615                 620         

<210>  3315
<211>  3979
<212>  DNA
<213>  Homo sapiens

<400>  3315
gagagcggcg cgcgcggcag ccccgaggca gcagagcgcg gagccgggag cgcggggagc     60

gcgggccggc ggcggcgagg gaggacgggg gcgcagacgg ccggcgcgcg gcgcggctac    120

catgggcgtg cggtgagcag ccgctcggga cgacttcctc ggctgcgcgg cgctcgcgcg    180

gagctccccg gccggcggtg cgtccccacg gtcaccatga aagacgactt cgcagaggag    240

gaggaggtgc aatccttcgg ttacaagcgg tttggtattc aggaaggaac acaatgtacc    300

aaatgtaaaa ataactgggc actgaagttt tctatcatat tattatacat tttgtgtgcc    360

ttgctaacaa tcacagtagc cattttggga tataaagttg tagagaaaat ggacaatgtc    420

acaggtggca tggaaacatc tcgccaaacc tatgatgaca agctcacagc agtggaaagt    480

gacctgaaaa aattaggtga ccaaactggg aagaaagcta tcagcaccaa ctcagaactc    540

tccaccttca gatcagacat tctagatctc cgtcagcaac ttcgtgagat tacagaaaaa    600

accagcaaga acaaggatac gctggagaag ttacaggcga gcggggatgc tctggtggac    660

aggcagagtc aattgaaaga aactttggag aataactctt tcctcatcac cactgtaaac    720

aaaaccctcc aggcgtataa tggctatgtc acgaatctgc agcaagatac cagcgtgctc    780

cagggcaatc tgcagaacca aatgtattct cataatgtgg tcatcatgaa cctcaacaac    840

ctgaacctga cccaggtgca gcagaggaac ctcatcacga atctgcagcg gtctgtggat    900

gacacaagcc aggctatcca gcgaatcaag aacgactttc aaaatctgca gcaggttttt    960

cttcaagcca agaaggacac ggattggctg aaggagaaag tgcagagctt gcagacgctg   1020

gctgccaaca actctgcgtt ggccaaagcc aacaacgaca ccctggagga tatgaacagc   1080

cagctcaact cattcacagg tcagatggag aacatcacca ctatctctca agccaacgag   1140

cagaacctga aagacctgca ggacttacac aaagatgcag agaatagaac agccatcaag   1200

ttcaaccaac tggaggaacg cttccagctc tttgagacgg atattgtgaa catcattagc   1260

aatatcagtt acacagccca ccacctgcgg acgctgacca gcaatctaaa tgaagtcagg   1320

accacttgca cagataccct taccaaacac acagatgatc tgacctcctt gaataatacc   1380

ctggccaaca tccgtttgga ttctgtttct ctcaggatgc aacaagattt gatgaggtcg   1440

aggttagaca ctgaagtagc caacttatca gtgattatgg aagaaatgaa gctagtagac   1500

tccaagcatg gtcagctcat caagaatttt acaatactac aaggtccacc gggccccagg   1560

ggtccaagag gtgacagagg atcccaggga ccccctggcc caactggcaa caagggacag   1620

aaaggagaga agggggagcc tggaccacct ggccctgcgg gtgagagagg cccaattgga   1680

ccagctggtc cccccggaga gcgtggcggc aaaggatcta aaggctccca gggccccaaa   1740

ggctcccgtg gttcccctgg gaagcccggc cctcagggct ccagtgggga cccaggcccc   1800

ccgggcccac caggcaaaga gggactcccc ggccctcagg gccctcctgg cttccaggga   1860

cttcagggca ccgttgggga gcctggggtg cctggacctc ggggactgcc aggcttgcct   1920

ggggtaccag gcatgccagg ccccaagggc ccccccggcc ctcctggccc atcaggagcg   1980

gtggtgcccc tggccctgca gaatgagcca accccagcac cggaggacaa tggctgcccg   2040

cctcactgga agaacttcac agacaaatgc tactattttt cagttgagaa agaaattttt   2100

gaggatgcaa agcttttctg tgaagacaag tcttcacatc ttgttttcat aaacactaga   2160

gaggaacagc aatggataaa aaaacagatg gtagggagag agagccactg gatcggcctc   2220

acagactcag agcgtgaaaa tgaatggaag tggctggatg ggacatctcc agactacaaa   2280

aattggaaag ctggacagcc ggataactgg ggtcatggcc atgggccagg agaagactgt   2340

gctgggttga tttatgctgg gcagtggaac gatttccaat gtgaagacgt caataacttc   2400

atttgcgaaa aagacaggga gacagtactg tcatctgcat tataacggac tgtgatggga   2460

tcacatgagc aaattttcag ctctcaaagg caaaggacac tcctttctaa ttgcatcacc   2520

ttctcatcag attgaaaaaa aaaaagcact gaaaaccaat tactgaaaaa aaattgacag   2580

ctagtgtttt ttaccatccg tcattaccca aagacttggg aactaaaatg ttccccaggg   2640

tgatatgctg attttcattg tgcacatgga ctgaatcaca tagattctcc tccgtcagta   2700

accgtgcgat tatacaaatt atgtcttcca aagtatggaa cactccaatc agaaaaaggt   2760

tatcattggt cgttgagtta tgggaagaac ttaagcatat actgtgtaaa cagtgccata   2820

catttctaaa atcccaagtg taggaaaaat atgcagacat acagatatat aggccaacta   2880

ttagtaataa tatgaaatat acttaaagag cttttaaaac tttgtatttt tgtacaaaat   2940

atttgtcttt tacaattttt ttcctttttt tttttttgtc attttaccga cataatacat   3000

ggagccaaag aaaacaataa tggtactaat aaaaactcct agggtttcct gtcagattta   3060

attctaccca gtggcaaaga attttttcaa ttgtggcttt aaaaaaataa ttaaatatac   3120

atgtgtatat atatatatat atatatattt tttttttttt ttttttttaa tgtttcattt   3180

cctcagagga accaatcact tggaatgtct agaaatatcc ttgcagattt tgccagtgtc   3240

aatcaagcct gcacacatgc acagtgaagc gggctgtgcc tgccttgagc ccatcaccag   3300

ccaacattct tgacgtgtgc ctgaccagac acagaagaaa tgggcaactc aagacgtgct   3360

tccacttcat tttggtggag tcgggaggtg tgggggatgg agaggcatct gttgggaagg   3420

gcactgaatc tggcctatct ggaaggccct gtgtcatggc tgagctatga ctgtacttgg   3480

catcagatcc ctacagagcc aacattaact gtcaggaacg tatggcgtca catcagccaa   3540

aggcagagat gctagaaaga tgggaaccgg ctacgtgtta cctggaaagt ttgttttctt   3600

aagtcatatt ccaaaaacat aactccaagg catacgcatg ataaaatgca agaataaact   3660

tttggccact ttgtggaact cttaaaagaa cctttccagc cgggcgcagt ggctcatgcc   3720

tgtaatccca gcactttggg aggccgaggc aggcagatga cttgaggtca ggagttcgag   3780

accagcctgg ccaacgtggc aaaaccccat ctctactaaa aataagaaaa ttagccgggt   3840

gtagtggcac atgcctgtaa tcccagctac tcaggaggct gaggcaggag aatcgcttga   3900

gcccaggagg cagagattgc agtgagccaa gatcgcacca ctgcactcca gcctcggtga   3960

cagagcaaga ctccatctc                                                3979


<210>  3316
<211>  742
<212>  PRT
<213>  Homo sapiens

<400>  3316


Met Lys Asp Asp Phe Ala Glu Glu Glu Glu Val Gln Ser Phe Gly Tyr 
1               5                   10                  15      


Lys Arg Phe Gly Ile Gln Glu Gly Thr Gln Cys Thr Lys Cys Lys Asn 
            20                  25                  30          


Asn Trp Ala Leu Lys Phe Ser Ile Ile Leu Leu Tyr Ile Leu Cys Ala 
        35                  40                  45              


Leu Leu Thr Ile Thr Val Ala Ile Leu Gly Tyr Lys Val Val Glu Lys 
    50                  55                  60                  


Met Asp Asn Val Thr Gly Gly Met Glu Thr Ser Arg Gln Thr Tyr Asp 
65                  70                  75                  80  


Asp Lys Leu Thr Ala Val Glu Ser Asp Leu Lys Lys Leu Gly Asp Gln 
                85                  90                  95      


Thr Gly Lys Lys Ala Ile Ser Thr Asn Ser Glu Leu Ser Thr Phe Arg 
            100                 105                 110         


Ser Asp Ile Leu Asp Leu Arg Gln Gln Leu Arg Glu Ile Thr Glu Lys 
        115                 120                 125             


Thr Ser Lys Asn Lys Asp Thr Leu Glu Lys Leu Gln Ala Ser Gly Asp 
    130                 135                 140                 


Ala Leu Val Asp Arg Gln Ser Gln Leu Lys Glu Thr Leu Glu Asn Asn 
145                 150                 155                 160 


Ser Phe Leu Ile Thr Thr Val Asn Lys Thr Leu Gln Ala Tyr Asn Gly 
                165                 170                 175     


Tyr Val Thr Asn Leu Gln Gln Asp Thr Ser Val Leu Gln Gly Asn Leu 
            180                 185                 190         


Gln Asn Gln Met Tyr Ser His Asn Val Val Ile Met Asn Leu Asn Asn 
        195                 200                 205             


Leu Asn Leu Thr Gln Val Gln Gln Arg Asn Leu Ile Thr Asn Leu Gln 
    210                 215                 220                 


Arg Ser Val Asp Asp Thr Ser Gln Ala Ile Gln Arg Ile Lys Asn Asp 
225                 230                 235                 240 


Phe Gln Asn Leu Gln Gln Val Phe Leu Gln Ala Lys Lys Asp Thr Asp 
                245                 250                 255     


Trp Leu Lys Glu Lys Val Gln Ser Leu Gln Thr Leu Ala Ala Asn Asn 
            260                 265                 270         


Ser Ala Leu Ala Lys Ala Asn Asn Asp Thr Leu Glu Asp Met Asn Ser 
        275                 280                 285             


Gln Leu Asn Ser Phe Thr Gly Gln Met Glu Asn Ile Thr Thr Ile Ser 
    290                 295                 300                 


Gln Ala Asn Glu Gln Asn Leu Lys Asp Leu Gln Asp Leu His Lys Asp 
305                 310                 315                 320 


Ala Glu Asn Arg Thr Ala Ile Lys Phe Asn Gln Leu Glu Glu Arg Phe 
                325                 330                 335     


Gln Leu Phe Glu Thr Asp Ile Val Asn Ile Ile Ser Asn Ile Ser Tyr 
            340                 345                 350         


Thr Ala His His Leu Arg Thr Leu Thr Ser Asn Leu Asn Glu Val Arg 
        355                 360                 365             


Thr Thr Cys Thr Asp Thr Leu Thr Lys His Thr Asp Asp Leu Thr Ser 
    370                 375                 380                 


Leu Asn Asn Thr Leu Ala Asn Ile Arg Leu Asp Ser Val Ser Leu Arg 
385                 390                 395                 400 


Met Gln Gln Asp Leu Met Arg Ser Arg Leu Asp Thr Glu Val Ala Asn 
                405                 410                 415     


Leu Ser Val Ile Met Glu Glu Met Lys Leu Val Asp Ser Lys His Gly 
            420                 425                 430         


Gln Leu Ile Lys Asn Phe Thr Ile Leu Gln Gly Pro Pro Gly Pro Arg 
        435                 440                 445             


Gly Pro Arg Gly Asp Arg Gly Ser Gln Gly Pro Pro Gly Pro Thr Gly 
    450                 455                 460                 


Asn Lys Gly Gln Lys Gly Glu Lys Gly Glu Pro Gly Pro Pro Gly Pro 
465                 470                 475                 480 


Ala Gly Glu Arg Gly Pro Ile Gly Pro Ala Gly Pro Pro Gly Glu Arg 
                485                 490                 495     


Gly Gly Lys Gly Ser Lys Gly Ser Gln Gly Pro Lys Gly Ser Arg Gly 
            500                 505                 510         


Ser Pro Gly Lys Pro Gly Pro Gln Gly Ser Ser Gly Asp Pro Gly Pro 
        515                 520                 525             


Pro Gly Pro Pro Gly Lys Glu Gly Leu Pro Gly Pro Gln Gly Pro Pro 
    530                 535                 540                 


Gly Phe Gln Gly Leu Gln Gly Thr Val Gly Glu Pro Gly Val Pro Gly 
545                 550                 555                 560 


Pro Arg Gly Leu Pro Gly Leu Pro Gly Val Pro Gly Met Pro Gly Pro 
                565                 570                 575     


Lys Gly Pro Pro Gly Pro Pro Gly Pro Ser Gly Ala Val Val Pro Leu 
            580                 585                 590         


Ala Leu Gln Asn Glu Pro Thr Pro Ala Pro Glu Asp Asn Gly Cys Pro 
        595                 600                 605             


Pro His Trp Lys Asn Phe Thr Asp Lys Cys Tyr Tyr Phe Ser Val Glu 
    610                 615                 620                 


Lys Glu Ile Phe Glu Asp Ala Lys Leu Phe Cys Glu Asp Lys Ser Ser 
625                 630                 635                 640 


His Leu Val Phe Ile Asn Thr Arg Glu Glu Gln Gln Trp Ile Lys Lys 
                645                 650                 655     


Gln Met Val Gly Arg Glu Ser His Trp Ile Gly Leu Thr Asp Ser Glu 
            660                 665                 670         


Arg Glu Asn Glu Trp Lys Trp Leu Asp Gly Thr Ser Pro Asp Tyr Lys 
        675                 680                 685             


Asn Trp Lys Ala Gly Gln Pro Asp Asn Trp Gly His Gly His Gly Pro 
    690                 695                 700                 


Gly Glu Asp Cys Ala Gly Leu Ile Tyr Ala Gly Gln Trp Asn Asp Phe 
705                 710                 715                 720 


Gln Cys Glu Asp Val Asn Asn Phe Ile Cys Glu Lys Asp Arg Glu Thr 
                725                 730                 735     


Val Leu Ser Ser Ala Leu 
            740         

<210>  3317
<211>  3022
<212>  DNA
<213>  Homo sapiens

<400>  3317
cgcgcgcggc agccccgagg cagcagagcg cggagccggg ataccatggg cgtgcggtga     60

gcagccgctc gggacgactt cctcggctgc gcggcgctcg cgcggagctc cccggccggc    120

ggtgcgtccc cacggtcacc atgaaagggt attcaggaag gaacacaatg taccaaatgt    180

aaaaataact gggcactgaa gttttctatc atattattat acattttgtg tgccttgcta    240

acaatcacag tagccatttt gggatataaa gttgtagaga aaatggacaa tgtcacaggt    300

ggcatggaaa catctcgcca aacctatgat gacaagctca cagcagtgga aagtgacctg    360

aaaaaattag gtgaccaaac tgggaagaaa gctatcagca ccaactcaga actctccacc    420

ttcagatcag acattctaga tctccgtcag caacttcgtg agattacaga aaaaaccagc    480

aagaacaagg atacgctgga gaagttacag gcgagcgggg atgctctggt ggacaggcag    540

agtcaattga aagaaacttt ggagaataac tctttcctca tcaccactgt aaacaaaacc    600

ctccaggcgt ataatggcta tgtcacgaat ctgcagcaag ataccagcgt gctccagggc    660

aatctgcaga accaaatgta ttctcataat gtggtcatca tgaacctcaa caacctgaac    720

ctgacccagg tgcagcagag gaacctcatc acgaatctgc agcggtctgt ggatgacaca    780

agccaggcta tccagcgaat caagaacgac tttcaaaatc tgcagcaggt ttttcttcaa    840

gccaagaagg acacggattg gctgaaggag aaagtgcaga gcttgcagac gctggctgcc    900

aacaactctg cgttggccaa agccaacaac gacaccctgg aggatatgaa cagccagctc    960

aactcattca caggtcagat ggagaacatc accactatct ctcaagccaa cgagcagaac   1020

ctgaaagacc tgcaggactt acacaaagat gcagagaata gaacagccat caagttcaac   1080

caactggagg aacgcttcca gctctttgag acggatattg tgaacatcat tagcaatatc   1140

agttacacag cccaccacct gcggacgctg accagcaatc taaatgaagt caggaccact   1200

tgcacagata cccttaccaa acacacagat gatctgacct ccttgaataa taccctggcc   1260

aacatccgtt tggattctgt ttctctcagg atgcaacaag atttgatgag gtcgaggtta   1320

gacactgaag tagccaactt atcagtgatt atggaagaaa tgaagctagt agactccaag   1380

catggtcagc tcatcaagaa ttttacaata ctacaaggtc caccgggccc caggggtcca   1440

agaggtgaca gaggatccca gggaccccct ggcccaactg gcaacaaggg acagaaagga   1500

gagaaggggg agcctggacc acctggccct gcgggtgaga gaggcccaat tggaccagct   1560

ggtccccccg gagagcgtgg cggcaaagga tctaaaggct cccagggccc caaaggctcc   1620

cgtggttccc ctgggaagcc cggccctcag ggctccagtg gggacccagg ccccccgggc   1680

ccaccaggca aagagggact ccccggccct cagggccctc ctggcttcca gggacttcag   1740

ggcaccgttg gggagcctgg ggtgcctgga cctcggggac tgccaggctt gcctggggta   1800

ccaggcatgc caggccccaa gggccccccc ggccctcctg gcccatcagg agcggtggtg   1860

cccctggccc tgcagaatga gccaacccca gcaccggagg acaatggctg cccgcctcac   1920

tggaagaact tcacagacaa atgctactat ttttcagttg agaaagaaat ttttgaggat   1980

gcaaagcttt tctgtgaaga caagtcttca catcttgttt tcataaacac tagagaggaa   2040

cagcaatgga taaaaaaaca gatggtaggg agagagagcc actggatcgg cctcacagac   2100

tcagagcgtg aaaatgaatg gaagtggctg gatgggacat ctccagacta caaaaattgg   2160

aaagctggac agccggataa ctggggtcat ggccatgggc caggagaaga ctgtgctggg   2220

ttgatttatg ctgggcagtg gaacgatttc caatgtgaag acgtcaataa cttcatttgc   2280

gaaaaagaca gggagacagt actgtcatct gcattataac ggactgtgat gggatcacat   2340

gagcaaattt tcagctctca aaggcaaagg acactccttt ctaattgcat caccttctca   2400

tcagattgaa aaaaaaaaag cactgaaaac caattactga aaaaaaattg acagctagtg   2460

ttttttacca tccgtcatta cccaaagact tgggaactaa aatgttcccc agggtgatat   2520

gctgattttc attgtgcaca tggactgaat cacatagatt ctcctccgtc agtaaccgtg   2580

cgattataca aattatgtct tccaaagtat ggaacactcc aatcagaaaa aggttatcat   2640

tggtcgttga gttatgggaa gaacttaagc atatactgtg taaacagtgc catacatttc   2700

taaaatccca agtgtaggaa aaatatgcag acatacagat atataggcca actattagta   2760

ataatatgaa atatacttaa agagctttta aaactttgta tttttgtaca aaatatttgt   2820

cttttacaat ttttttcctt tttttttttt tgtcatttta ccgacataat acatggagcc   2880

aaagaaaaca ataatggtac taataaaaac tcctagggtt tcctgtcaga tttaattcta   2940

cccagtggca aagaattttt tcaattgtgg ctttaaaaaa ataattaaat atacatgtgt   3000

atatatatat atatatatat at                                            3022


<210>  3318
<211>  678
<212>  PRT
<213>  Homo sapiens

<400>  3318


Met Asp Asn Val Thr Gly Gly Met Glu Thr Ser Arg Gln Thr Tyr Asp 
1               5                   10                  15      


Asp Lys Leu Thr Ala Val Glu Ser Asp Leu Lys Lys Leu Gly Asp Gln 
            20                  25                  30          


Thr Gly Lys Lys Ala Ile Ser Thr Asn Ser Glu Leu Ser Thr Phe Arg 
        35                  40                  45              


Ser Asp Ile Leu Asp Leu Arg Gln Gln Leu Arg Glu Ile Thr Glu Lys 
    50                  55                  60                  


Thr Ser Lys Asn Lys Asp Thr Leu Glu Lys Leu Gln Ala Ser Gly Asp 
65                  70                  75                  80  


Ala Leu Val Asp Arg Gln Ser Gln Leu Lys Glu Thr Leu Glu Asn Asn 
                85                  90                  95      


Ser Phe Leu Ile Thr Thr Val Asn Lys Thr Leu Gln Ala Tyr Asn Gly 
            100                 105                 110         


Tyr Val Thr Asn Leu Gln Gln Asp Thr Ser Val Leu Gln Gly Asn Leu 
        115                 120                 125             


Gln Asn Gln Met Tyr Ser His Asn Val Val Ile Met Asn Leu Asn Asn 
    130                 135                 140                 


Leu Asn Leu Thr Gln Val Gln Gln Arg Asn Leu Ile Thr Asn Leu Gln 
145                 150                 155                 160 


Arg Ser Val Asp Asp Thr Ser Gln Ala Ile Gln Arg Ile Lys Asn Asp 
                165                 170                 175     


Phe Gln Asn Leu Gln Gln Val Phe Leu Gln Ala Lys Lys Asp Thr Asp 
            180                 185                 190         


Trp Leu Lys Glu Lys Val Gln Ser Leu Gln Thr Leu Ala Ala Asn Asn 
        195                 200                 205             


Ser Ala Leu Ala Lys Ala Asn Asn Asp Thr Leu Glu Asp Met Asn Ser 
    210                 215                 220                 


Gln Leu Asn Ser Phe Thr Gly Gln Met Glu Asn Ile Thr Thr Ile Ser 
225                 230                 235                 240 


Gln Ala Asn Glu Gln Asn Leu Lys Asp Leu Gln Asp Leu His Lys Asp 
                245                 250                 255     


Ala Glu Asn Arg Thr Ala Ile Lys Phe Asn Gln Leu Glu Glu Arg Phe 
            260                 265                 270         


Gln Leu Phe Glu Thr Asp Ile Val Asn Ile Ile Ser Asn Ile Ser Tyr 
        275                 280                 285             


Thr Ala His His Leu Arg Thr Leu Thr Ser Asn Leu Asn Glu Val Arg 
    290                 295                 300                 


Thr Thr Cys Thr Asp Thr Leu Thr Lys His Thr Asp Asp Leu Thr Ser 
305                 310                 315                 320 


Leu Asn Asn Thr Leu Ala Asn Ile Arg Leu Asp Ser Val Ser Leu Arg 
                325                 330                 335     


Met Gln Gln Asp Leu Met Arg Ser Arg Leu Asp Thr Glu Val Ala Asn 
            340                 345                 350         


Leu Ser Val Ile Met Glu Glu Met Lys Leu Val Asp Ser Lys His Gly 
        355                 360                 365             


Gln Leu Ile Lys Asn Phe Thr Ile Leu Gln Gly Pro Pro Gly Pro Arg 
    370                 375                 380                 


Gly Pro Arg Gly Asp Arg Gly Ser Gln Gly Pro Pro Gly Pro Thr Gly 
385                 390                 395                 400 


Asn Lys Gly Gln Lys Gly Glu Lys Gly Glu Pro Gly Pro Pro Gly Pro 
                405                 410                 415     


Ala Gly Glu Arg Gly Pro Ile Gly Pro Ala Gly Pro Pro Gly Glu Arg 
            420                 425                 430         


Gly Gly Lys Gly Ser Lys Gly Ser Gln Gly Pro Lys Gly Ser Arg Gly 
        435                 440                 445             


Ser Pro Gly Lys Pro Gly Pro Gln Gly Ser Ser Gly Asp Pro Gly Pro 
    450                 455                 460                 


Pro Gly Pro Pro Gly Lys Glu Gly Leu Pro Gly Pro Gln Gly Pro Pro 
465                 470                 475                 480 


Gly Phe Gln Gly Leu Gln Gly Thr Val Gly Glu Pro Gly Val Pro Gly 
                485                 490                 495     


Pro Arg Gly Leu Pro Gly Leu Pro Gly Val Pro Gly Met Pro Gly Pro 
            500                 505                 510         


Lys Gly Pro Pro Gly Pro Pro Gly Pro Ser Gly Ala Val Val Pro Leu 
        515                 520                 525             


Ala Leu Gln Asn Glu Pro Thr Pro Ala Pro Glu Asp Asn Gly Cys Pro 
    530                 535                 540                 


Pro His Trp Lys Asn Phe Thr Asp Lys Cys Tyr Tyr Phe Ser Val Glu 
545                 550                 555                 560 


Lys Glu Ile Phe Glu Asp Ala Lys Leu Phe Cys Glu Asp Lys Ser Ser 
                565                 570                 575     


His Leu Val Phe Ile Asn Thr Arg Glu Glu Gln Gln Trp Ile Lys Lys 
            580                 585                 590         


Gln Met Val Gly Arg Glu Ser His Trp Ile Gly Leu Thr Asp Ser Glu 
        595                 600                 605             


Arg Glu Asn Glu Trp Lys Trp Leu Asp Gly Thr Ser Pro Asp Tyr Lys 
    610                 615                 620                 


Asn Trp Lys Ala Gly Gln Pro Asp Asn Trp Gly His Gly His Gly Pro 
625                 630                 635                 640 


Gly Glu Asp Cys Ala Gly Leu Ile Tyr Ala Gly Gln Trp Asn Asp Phe 
                645                 650                 655     


Gln Cys Glu Asp Val Asn Asn Phe Ile Cys Glu Lys Asp Arg Glu Thr 
            660                 665                 670         


Val Leu Ser Ser Ala Leu 
        675             

<210>  3319
<211>  4746
<212>  DNA
<213>  Homo sapiens

<400>  3319
gagagcggcg cgcgcggcag ccccgaggca gcagagcgcg gagccgggag cgcggggagc     60

gcgggccggc ggcggcgagg gaggacgggg gcgcagacgg ccggcgcgcg gcgcggctac    120

catgggcgtg cggtgagcag ccgctcggga cgacttcctc ggctgcgcgg cgctcgcgcg    180

gagctccccg gccggcggtg cgtccccacg gtcaccatga aagacgactt cgcagaggag    240

gaggaggtgc aatccttcgg ttacaagcgg tttggtattc aggaaggaac acaatgtacc    300

aaatgtaaaa ataactgggc actgaagttt tctatcatat tattatacat tttgtgtgcc    360

ttgctaacaa tcacagtagc cattttggga tataaagttg tagagaaaat ggacaatgtc    420

acaggtggca tggaaacatc tcgccaaacc tatgatgaca agctcacagc agtggaaagt    480

gacctgaaaa aattaggtga ccaaactggg aagaaagcta tcagcaccaa ctcagaactc    540

tccaccttca gatcagacat tctagatctc cgtcagcaac ttcgtgagat tacagaaaaa    600

accagcaaga acaaggatac gctggagaag ttacaggcga gcggggatgc tctggtggac    660

aggcagagtc aattgaaaga aactttggag aataactctt tcctcatcac cactgtaaac    720

aaaaccctcc aggcgtataa tggctatgtc acgaatctgc agcaagatac cagcgtgctc    780

cagggcaatc tgcagaacca aatgtattct cataatgtgg tcatcatgaa cctcaacaac    840

ctgaacctga cccaggtgca gcagaggaac ctcatcacga atctgcagcg gtctgtggat    900

gacacaagcc aggctatcca gcgaatcaag aacgactttc aaaatctgca gcaggttttt    960

cttcaagcca agaaggacac ggattggctg aaggagaaag tgcagagctt gcagacgctg   1020

gctgccaaca actctgcgtt ggccaaagcc aacaacgaca ccctggagga tatgaacagc   1080

cagctcaact cattcacagg tcagatggag aacatcacca ctatctctca agccaacgag   1140

cagaacctga aagacctgca ggacttacac aaagatgcag agaatagaac agccatcaag   1200

ttcaaccaac tggaggaacg cttccagctc tttgagacgg atattgtgaa catcattagc   1260

aatatcagtt acacagccca ccacctgcgg acgctgacca gcaatctaaa tgaagtcagg   1320

accacttgca cagataccct taccaaacac acagatgatc tgacctcctt gaataatacc   1380

ctggccaaca tccgtttgga ttctgtttct ctcaggatgc aacaagattt gatgaggtcg   1440

aggttagaca ctgaagtagc caacttatca gtgattatgg aagaaatgaa gctagtagac   1500

tccaagcatg gtcagctcat caagaatttt acaatactac aaggtccacc gggccccagg   1560

ggtccaagag gtgacagagg atcccaggga ccccctggcc caactggcaa caagggacag   1620

aaaggagaga agggggagcc tggaccacct ggccctgcgg gtgagagagg cccaattgga   1680

ccagctggtc cccccggaga gcgtggcggc aaaggatcta aaggctccca gggccccaaa   1740

ggctcccgtg gttcccctgg gaagcccggc cctcagggct ccagtgggga cccaggcccc   1800

ccgggcccac caggcaaaga gggactcccc ggccctcagg gccctcctgg cttccaggga   1860

cttcagggca ccgttgggga gcctggggtg cctggacctc ggggactgcc aggcttgcct   1920

ggggtaccag gcatgccagg ccccaagggc ccccccggcc ctcctggccc atcaggagcg   1980

gtggtgcccc tggccctgca gaatgagcca accccagcac cggaggacaa tggtaagtcc   2040

aagccctccc tccagccagg gggacagggc agtgcatgtg cttgagactg agccaacccc   2100

cagtgtgtgg ccccacccat gttatttttg tttttgtttt tgttttgaga cagggtctca   2160

ctctgttgcc caggctggag tgcagtggcg tgatctcggc tcactgcaac ctccacatcc   2220

cgggttcaag tgattctcct gccttagcct cccaggtagc tgggactaca agcgtgtgcc   2280

cccacagcca gctaattttt gtatttttag tagagagggg gtttcaccgt gttggccagg   2340

ctggtctcaa actcctggcc tcaagtgatc cacctacctt agtctcccaa agtgctggga   2400

ttacaggtgt gagccaccac gtcttgtccc ccgctgcata ttatttaaca gcaaaggcat   2460

cataggggct ggcacaggag ccctgctgcc agaacaggcc tccataccag gcatgtgttt   2520

ctctctaaac gccattgggt tctctagtgc tcatttgttt tatgtattat gtgtgtatgt   2580

atgggacagg gtctcactct gtcacccagg ctggaatgac gaagtgaagt agtgcaaaca   2640

tagctcactg cagctttgac ctcctgggct taggtgatct tcccactcag actcctgcgt   2700

agctgggacc acaggggtat gccaccacac ctggctaatt ttttattttc ctttttgtag   2760

agacagggtc ttgctatgtt gcccaggctg gtcttgaact cctggcctca agcaaccctc   2820

ctgcctcagt cttgcaaagt gctgggattc caggtgggag ccactgcacc tggctcttgc   2880

acttgtttat ttataggagc cagccctcag aagacaaaca caatgcaaaa catttccttc   2940

agggaagcct gctggccgcc ctgagcgctc ttccctcgtt ttacatcctc actctggaga   3000

tagatgggct ccctcggtta gctccatcaa catgtggatg gaaccctctg ctattgatga   3060

ctacatttaa tttctttttg agaaaggtgt tagatgttac ggtgccttct agtcttttga   3120

taattaaacc tttggcaaaa ctcgaatgtt tggttagcaa ccaagcctat ttttctctcc   3180

tttgacccaa ccgctattct acttgatttt ggtcggtgag gcccgggtta tttttgttga   3240

tccgtgagcc cagttttggt gctgggttct cacatccaag tgttcctggg ttccgtatga   3300

ttccagactg acgctgaaca tctgtgcctg ccctgcttct tgttgttgct tctgttattt   3360

ctgtcattgt gaagacggat ccagacacag aagaacaaag acccagtcaa agatcttttc   3420

cagattatgt ggttttggct tgtgctctgc agtccacttt gggtcatgct tgctgcgagc   3480

acgtccgtga acgtcagctg tgggcctcgt gcagggacgc tcaggctgct cccagcggga   3540

ccacagtttt ggcctctgaa acacagctga agaaaggcag agtgctttct gtgatctttt   3600

aatcaatgtt ttccactttt gcattcctag gctgcccgcc tcactggaag aacttcacag   3660

acaaatgcta ctatttttca gttgagaaag aaatttttga ggatgcaaag cttttctgtg   3720

aagacaagtc ttcacatctt gttttcataa acactagaga ggaacagcaa tggataaaaa   3780

aacagatggt agggagagag agccactgga tcggcctcac agactcagag cgtgaaaatg   3840

aatggaagtg gctggatggg acatctccag actacaaaaa ttggaaagct ggacagccgg   3900

ataactgggg tcatggccat gggccaggag aagactgtgc tgggttgatt tatgctgggc   3960

agtggaacga tttccaatgt gaagacgtca ataacttcat ttgcgaaaaa gacagggaga   4020

cagtactgtc atctgcatta taacggactg tgatgggatc acatgagcaa attttcagct   4080

ctcaaaggca aaggacactc ctttctaatt gcatcacctt ctcatcagat tgaaaaaaaa   4140

aaagcactga aaaccaatta ctgaaaaaaa attgacagct agtgtttttt accatccgtc   4200

attacccaaa gacttgggaa ctaaaatgtt ccccagggtg atatgctgat tttcattgtg   4260

cacatggact gaatcacata gattctcctc cgtcagtaac cgtgcgatta tacaaattat   4320

gtcttccaaa gtatggaaca ctccaatcag aaaaaggtta tcattggtcg ttgagttatg   4380

ggaagaactt aagcatatac tgtgtaaaca gtgccataca tttctaaaat cccaagtgta   4440

ggaaaaatat gcagacatac agatatatag gccaactatt agtaataata tgaaatatac   4500

ttaaagagct tttaaaactt tgtatttttg tacaaaatat ttgtctttta caattttttt   4560

cctttttttt tttttgtcat tttaccgaca taatacatgg agccaaagaa aacaataatg   4620

gtactaataa aaactcctag ggtttcctgt cagatttaat tctacccagt ggcaaagaat   4680

tttttcaatt gtggctttaa aaaaataatt aaatatacat gtgtatatat atatatatat   4740

atatat                                                              4746


<210>  3320
<211>  622
<212>  PRT
<213>  Homo sapiens

<400>  3320


Met Lys Asp Asp Phe Ala Glu Glu Glu Glu Val Gln Ser Phe Gly Tyr 
1               5                   10                  15      


Lys Arg Phe Gly Ile Gln Glu Gly Thr Gln Cys Thr Lys Cys Lys Asn 
            20                  25                  30          


Asn Trp Ala Leu Lys Phe Ser Ile Ile Leu Leu Tyr Ile Leu Cys Ala 
        35                  40                  45              


Leu Leu Thr Ile Thr Val Ala Ile Leu Gly Tyr Lys Val Val Glu Lys 
    50                  55                  60                  


Met Asp Asn Val Thr Gly Gly Met Glu Thr Ser Arg Gln Thr Tyr Asp 
65                  70                  75                  80  


Asp Lys Leu Thr Ala Val Glu Ser Asp Leu Lys Lys Leu Gly Asp Gln 
                85                  90                  95      


Thr Gly Lys Lys Ala Ile Ser Thr Asn Ser Glu Leu Ser Thr Phe Arg 
            100                 105                 110         


Ser Asp Ile Leu Asp Leu Arg Gln Gln Leu Arg Glu Ile Thr Glu Lys 
        115                 120                 125             


Thr Ser Lys Asn Lys Asp Thr Leu Glu Lys Leu Gln Ala Ser Gly Asp 
    130                 135                 140                 


Ala Leu Val Asp Arg Gln Ser Gln Leu Lys Glu Thr Leu Glu Asn Asn 
145                 150                 155                 160 


Ser Phe Leu Ile Thr Thr Val Asn Lys Thr Leu Gln Ala Tyr Asn Gly 
                165                 170                 175     


Tyr Val Thr Asn Leu Gln Gln Asp Thr Ser Val Leu Gln Gly Asn Leu 
            180                 185                 190         


Gln Asn Gln Met Tyr Ser His Asn Val Val Ile Met Asn Leu Asn Asn 
        195                 200                 205             


Leu Asn Leu Thr Gln Val Gln Gln Arg Asn Leu Ile Thr Asn Leu Gln 
    210                 215                 220                 


Arg Ser Val Asp Asp Thr Ser Gln Ala Ile Gln Arg Ile Lys Asn Asp 
225                 230                 235                 240 


Phe Gln Asn Leu Gln Gln Val Phe Leu Gln Ala Lys Lys Asp Thr Asp 
                245                 250                 255     


Trp Leu Lys Glu Lys Val Gln Ser Leu Gln Thr Leu Ala Ala Asn Asn 
            260                 265                 270         


Ser Ala Leu Ala Lys Ala Asn Asn Asp Thr Leu Glu Asp Met Asn Ser 
        275                 280                 285             


Gln Leu Asn Ser Phe Thr Gly Gln Met Glu Asn Ile Thr Thr Ile Ser 
    290                 295                 300                 


Gln Ala Asn Glu Gln Asn Leu Lys Asp Leu Gln Asp Leu His Lys Asp 
305                 310                 315                 320 


Ala Glu Asn Arg Thr Ala Ile Lys Phe Asn Gln Leu Glu Glu Arg Phe 
                325                 330                 335     


Gln Leu Phe Glu Thr Asp Ile Val Asn Ile Ile Ser Asn Ile Ser Tyr 
            340                 345                 350         


Thr Ala His His Leu Arg Thr Leu Thr Ser Asn Leu Asn Glu Val Arg 
        355                 360                 365             


Thr Thr Cys Thr Asp Thr Leu Thr Lys His Thr Asp Asp Leu Thr Ser 
    370                 375                 380                 


Leu Asn Asn Thr Leu Ala Asn Ile Arg Leu Asp Ser Val Ser Leu Arg 
385                 390                 395                 400 


Met Gln Gln Asp Leu Met Arg Ser Arg Leu Asp Thr Glu Val Ala Asn 
                405                 410                 415     


Leu Ser Val Ile Met Glu Glu Met Lys Leu Val Asp Ser Lys His Gly 
            420                 425                 430         


Gln Leu Ile Lys Asn Phe Thr Ile Leu Gln Gly Pro Pro Gly Pro Arg 
        435                 440                 445             


Gly Pro Arg Gly Asp Arg Gly Ser Gln Gly Pro Pro Gly Pro Thr Gly 
    450                 455                 460                 


Asn Lys Gly Gln Lys Gly Glu Lys Gly Glu Pro Gly Pro Pro Gly Pro 
465                 470                 475                 480 


Ala Gly Glu Arg Gly Pro Ile Gly Pro Ala Gly Pro Pro Gly Glu Arg 
                485                 490                 495     


Gly Gly Lys Gly Ser Lys Gly Ser Gln Gly Pro Lys Gly Ser Arg Gly 
            500                 505                 510         


Ser Pro Gly Lys Pro Gly Pro Gln Gly Ser Ser Gly Asp Pro Gly Pro 
        515                 520                 525             


Pro Gly Pro Pro Gly Lys Glu Gly Leu Pro Gly Pro Gln Gly Pro Pro 
    530                 535                 540                 


Gly Phe Gln Gly Leu Gln Gly Thr Val Gly Glu Pro Gly Val Pro Gly 
545                 550                 555                 560 


Pro Arg Gly Leu Pro Gly Leu Pro Gly Val Pro Gly Met Pro Gly Pro 
                565                 570                 575     


Lys Gly Pro Pro Gly Pro Pro Gly Pro Ser Gly Ala Val Val Pro Leu 
            580                 585                 590         


Ala Leu Gln Asn Glu Pro Thr Pro Ala Pro Glu Asp Asn Gly Lys Ser 
        595                 600                 605             


Lys Pro Ser Leu Gln Pro Gly Gly Gln Gly Ser Ala Cys Ala 
    610                 615                 620         

<210>  3321
<211>  3148
<212>  DNA
<213>  Homo sapiens

<400>  3321
gagagcggcg cgcgcggcag ccccgaggca gcagagcgcg gagccgggag cgcggggagc     60

gcgggccggc ggcggcgagg gaggacgggg gcgcagacgg ccggcgcgcg gcgcggctac    120

catgggcgtg cggtgagcag ccgctcggga cgacttcctc ggctgcgcgg cgctcgcgcg    180

gagctccccg gccggcggtg cgtccccacg gtcaccatga aagacgactt cgcagaggag    240

gaggaggtgc aatccttcgg ttacaagcgg tttggtattc aggaaggaac acaatgtacc    300

aaatgtaaaa ataactgggc actgaagttt tctatcatat tattatacat tttgtgtgcc    360

ttgctaacaa tcacagtagc cattttggga tataaagttg tagagaaaat ggacaatgtc    420

acaggtggca tggaaacatc tcgccaaacc tatgatgaca agctcacagc agtggaaagt    480

gacctgaaaa aattaggtga ccaaactggg aagaaagcta tcagcaccaa ctcagaactc    540

tccaccttca gatcagacat tctagatctc cgtcagcaac ttcgtgagat tacagaaaaa    600

accagcaaga acaaggatac gctggagaag ttacaggcga gcggggatgc tctggtggac    660

aggcagagtc aattgaaaga aactttggag aataactctt tcctcatcac cactgtaaac    720

aaaaccctcc aggcgtataa tggctatgtc acgaatctgc agcaagatac cagcgtgctc    780

cagggcaatc tgcagaacca aatgtattct cataatgtgg tcatcatgaa cctcaacaac    840

ctgaacctga cccaggtgca gcagaggaac ctcatcacga atctgcagcg gtctgtggat    900

gacacaagcc aggctatcca gcgaatcaag aacgactttc aaaatctgca gcaggttttt    960

cttcaagcca agaaggacac ggattggctg aaggagaaag tgcagagctt gcagacgctg   1020

gctgccaaca actctgcgtt ggccaaagcc aacaacgaca ccctggagga tatgaacagc   1080

cagctcaact cattcacagg tcagatggag aacatcacca ctatctctca agccaacgag   1140

cagaacctga aagacctgca ggacttacac aaagatgcag agaatagaac agccatcaag   1200

ttcaaccaac tggaggaacg cttccagctc tttgagacgg atattgtgaa catcattagc   1260

aatatcagtt acacagccca ccacctgcgg acgctgacca gcaatctaaa tgaagtcagg   1320

accacttgca cagataccct taccaaacac acagatgatc tgacctcctt gaataatacc   1380

ctggccaaca tccgtttgga ttctgtttct ctcaggatgc aacaagattt gatgaggtcg   1440

aggttagaca ctgaagtagc caacttatca gtgattatgg aagaaatgaa gctagtagac   1500

tccaagcatg gtcagctcat caagaatttt acaatactac aaggtccacc gggccccagg   1560

ggtccaagag gtgacagagg atcccaggga ccccctggcc caactggcaa caagggacag   1620

aaaggagaga agggggagcc tggaccacct ggccctgcgg gtgagagagg cccaattgga   1680

ccagctggtc cccccggaga gcgtggcggc aaaggatcta aaggctccca gggccccaaa   1740

ggctcccgtg gttcccctgg gaagcccggc cctcagggct ccagtgggga cccaggcccc   1800

ccgggcccac caggcaaaga gggactcccc ggccctcagg gccctcctgg cttccaggga   1860

cttcagggca ccgttgggga gcctggggtg cctggacctc ggggactgcc aggcttgcct   1920

ggggtaccag gcatgccagg ccccaagggc ccccccggcc ctcctggccc atcaggagcg   1980

gtggtgcccc tggccctgca gaatgagcca accccagcac cggaggacaa tggctgcccg   2040

cctcactgga agaacttcac agacaaatgc tactattttt cagttgagaa agaaattttt   2100

gaggatgcaa agcttttctg tgaagacaag tcttcacatc ttgttttcat aaacactaga   2160

gaggaacagc aatggataaa aaaacagatg gtagggagag agagccactg gatcggcctc   2220

acagactcag agcgtgaaaa tgaatggaag tggctggatg ggacatctcc agactacaaa   2280

aattggaaag ctggacagcc ggataactgg ggtcatggcc atgggccagg agaagactgt   2340

gctgggttga tttatgctgg gcagtggaac gatttccaat gtgaagacgt caataacttc   2400

atttgcgaaa aagacaggga gacagtactg tcatctgcat tataacggac tgtgatggga   2460

tcacatgagc aaattttcag ctctcaaagg caaaggacac tcctttctaa ttgcatcacc   2520

ttctcatcag attgaaaaaa aaaaagcact gaaaaccaat tactgaaaaa aaattgacag   2580

ctagtgtttt ttaccatccg tcattaccca aagacttggg aactaaaatg ttccccaggg   2640

tgatatgctg attttcattg tgcacatgga ctgaatcaca tagattctcc tccgtcagta   2700

accgtgcgat tatacaaatt atgtcttcca aagtatggaa cactccaatc agaaaaaggt   2760

tatcattggt cgttgagtta tgggaagaac ttaagcatat actgtgtaaa cagtgccata   2820

catttctaaa atcccaagtg taggaaaaat atgcagacat acagatatat aggccaacta   2880

ttagtaataa tatgaaatat acttaaagag cttttaaaac tttgtatttt tgtacaaaat   2940

atttgtcttt tacaattttt ttcctttttt tttttttgtc attttaccga cataatacat   3000

ggagccaaag aaaacaataa tggtactaat aaaaactcct agggtttcct gtcagattta   3060

attctaccca gtggcaaaga attttttcaa ttgtggcttt aaaaaaataa ttaaatatac   3120

atgtgtatat atatatatat atatatat                                      3148


<210>  3322
<211>  742
<212>  PRT
<213>  Homo sapiens

<400>  3322


Met Lys Asp Asp Phe Ala Glu Glu Glu Glu Val Gln Ser Phe Gly Tyr 
1               5                   10                  15      


Lys Arg Phe Gly Ile Gln Glu Gly Thr Gln Cys Thr Lys Cys Lys Asn 
            20                  25                  30          


Asn Trp Ala Leu Lys Phe Ser Ile Ile Leu Leu Tyr Ile Leu Cys Ala 
        35                  40                  45              


Leu Leu Thr Ile Thr Val Ala Ile Leu Gly Tyr Lys Val Val Glu Lys 
    50                  55                  60                  


Met Asp Asn Val Thr Gly Gly Met Glu Thr Ser Arg Gln Thr Tyr Asp 
65                  70                  75                  80  


Asp Lys Leu Thr Ala Val Glu Ser Asp Leu Lys Lys Leu Gly Asp Gln 
                85                  90                  95      


Thr Gly Lys Lys Ala Ile Ser Thr Asn Ser Glu Leu Ser Thr Phe Arg 
            100                 105                 110         


Ser Asp Ile Leu Asp Leu Arg Gln Gln Leu Arg Glu Ile Thr Glu Lys 
        115                 120                 125             


Thr Ser Lys Asn Lys Asp Thr Leu Glu Lys Leu Gln Ala Ser Gly Asp 
    130                 135                 140                 


Ala Leu Val Asp Arg Gln Ser Gln Leu Lys Glu Thr Leu Glu Asn Asn 
145                 150                 155                 160 


Ser Phe Leu Ile Thr Thr Val Asn Lys Thr Leu Gln Ala Tyr Asn Gly 
                165                 170                 175     


Tyr Val Thr Asn Leu Gln Gln Asp Thr Ser Val Leu Gln Gly Asn Leu 
            180                 185                 190         


Gln Asn Gln Met Tyr Ser His Asn Val Val Ile Met Asn Leu Asn Asn 
        195                 200                 205             


Leu Asn Leu Thr Gln Val Gln Gln Arg Asn Leu Ile Thr Asn Leu Gln 
    210                 215                 220                 


Arg Ser Val Asp Asp Thr Ser Gln Ala Ile Gln Arg Ile Lys Asn Asp 
225                 230                 235                 240 


Phe Gln Asn Leu Gln Gln Val Phe Leu Gln Ala Lys Lys Asp Thr Asp 
                245                 250                 255     


Trp Leu Lys Glu Lys Val Gln Ser Leu Gln Thr Leu Ala Ala Asn Asn 
            260                 265                 270         


Ser Ala Leu Ala Lys Ala Asn Asn Asp Thr Leu Glu Asp Met Asn Ser 
        275                 280                 285             


Gln Leu Asn Ser Phe Thr Gly Gln Met Glu Asn Ile Thr Thr Ile Ser 
    290                 295                 300                 


Gln Ala Asn Glu Gln Asn Leu Lys Asp Leu Gln Asp Leu His Lys Asp 
305                 310                 315                 320 


Ala Glu Asn Arg Thr Ala Ile Lys Phe Asn Gln Leu Glu Glu Arg Phe 
                325                 330                 335     


Gln Leu Phe Glu Thr Asp Ile Val Asn Ile Ile Ser Asn Ile Ser Tyr 
            340                 345                 350         


Thr Ala His His Leu Arg Thr Leu Thr Ser Asn Leu Asn Glu Val Arg 
        355                 360                 365             


Thr Thr Cys Thr Asp Thr Leu Thr Lys His Thr Asp Asp Leu Thr Ser 
    370                 375                 380                 


Leu Asn Asn Thr Leu Ala Asn Ile Arg Leu Asp Ser Val Ser Leu Arg 
385                 390                 395                 400 


Met Gln Gln Asp Leu Met Arg Ser Arg Leu Asp Thr Glu Val Ala Asn 
                405                 410                 415     


Leu Ser Val Ile Met Glu Glu Met Lys Leu Val Asp Ser Lys His Gly 
            420                 425                 430         


Gln Leu Ile Lys Asn Phe Thr Ile Leu Gln Gly Pro Pro Gly Pro Arg 
        435                 440                 445             


Gly Pro Arg Gly Asp Arg Gly Ser Gln Gly Pro Pro Gly Pro Thr Gly 
    450                 455                 460                 


Asn Lys Gly Gln Lys Gly Glu Lys Gly Glu Pro Gly Pro Pro Gly Pro 
465                 470                 475                 480 


Ala Gly Glu Arg Gly Pro Ile Gly Pro Ala Gly Pro Pro Gly Glu Arg 
                485                 490                 495     


Gly Gly Lys Gly Ser Lys Gly Ser Gln Gly Pro Lys Gly Ser Arg Gly 
            500                 505                 510         


Ser Pro Gly Lys Pro Gly Pro Gln Gly Ser Ser Gly Asp Pro Gly Pro 
        515                 520                 525             


Pro Gly Pro Pro Gly Lys Glu Gly Leu Pro Gly Pro Gln Gly Pro Pro 
    530                 535                 540                 


Gly Phe Gln Gly Leu Gln Gly Thr Val Gly Glu Pro Gly Val Pro Gly 
545                 550                 555                 560 


Pro Arg Gly Leu Pro Gly Leu Pro Gly Val Pro Gly Met Pro Gly Pro 
                565                 570                 575     


Lys Gly Pro Pro Gly Pro Pro Gly Pro Ser Gly Ala Val Val Pro Leu 
            580                 585                 590         


Ala Leu Gln Asn Glu Pro Thr Pro Ala Pro Glu Asp Asn Gly Cys Pro 
        595                 600                 605             


Pro His Trp Lys Asn Phe Thr Asp Lys Cys Tyr Tyr Phe Ser Val Glu 
    610                 615                 620                 


Lys Glu Ile Phe Glu Asp Ala Lys Leu Phe Cys Glu Asp Lys Ser Ser 
625                 630                 635                 640 


His Leu Val Phe Ile Asn Thr Arg Glu Glu Gln Gln Trp Ile Lys Lys 
                645                 650                 655     


Gln Met Val Gly Arg Glu Ser His Trp Ile Gly Leu Thr Asp Ser Glu 
            660                 665                 670         


Arg Glu Asn Glu Trp Lys Trp Leu Asp Gly Thr Ser Pro Asp Tyr Lys 
        675                 680                 685             


Asn Trp Lys Ala Gly Gln Pro Asp Asn Trp Gly His Gly His Gly Pro 
    690                 695                 700                 


Gly Glu Asp Cys Ala Gly Leu Ile Tyr Ala Gly Gln Trp Asn Asp Phe 
705                 710                 715                 720 


Gln Cys Glu Asp Val Asn Asn Phe Ile Cys Glu Lys Asp Arg Glu Thr 
                725                 730                 735     


Val Leu Ser Ser Ala Leu 
            740         

<210>  3323
<211>  2939
<212>  DNA
<213>  Homo sapiens

<400>  3323
cgcgcgcggc agccccgagg cagcagagcg cggagccggg ataccatggg cgtgcggtga     60

gcagccgctc gggacgactt cctcggctgc gcggcgctcg cgcggagctc cccggccggc    120

ggtgcgtccc cacggtcacc atgaaagggt attcaggaag gaacacaatg taccaaatgt    180

aaaaataact gggcactgaa gttttctatc atattattat acattttgtg tgccttgcta    240

acaatcacag tagccatttt gggatataaa gttgtagaga aaatggacaa tgtcacaggt    300

ggcatggaaa catctcgcca aacctatgat gacaagctca cagcagtgga aagtgacctg    360

aaaaaattag gtgaccaaac tgggaagaaa gctatcagca ccaactcaga actctccacc    420

ttcagatcag acattctaga tctccgtcag caacttcgtg agattacaga aaaaaccagc    480

aagaacaagg atacgctgga gaagttacag gcgagcgggg atgctctggt ggacaggcag    540

agtcaattga aagaaacttt ggagaataac tctttcctca tcaccactgt aaacaaaacc    600

ctccaggcgt ataatggcta tgtcacgaat ctgcagcaag ataccagcgt gctccagggc    660

aatctgcaga accaaatgta ttctcataat gtggtcatca tgaacctcaa caacctgaac    720

ctgacccagg tgcagcagag gaacctcatc acgaatctgc agcggtctgt ggatgacaca    780

agccaggcta tccagcgaat caagaacgac tttcaaaatc tgcagcaggt ttttcttcaa    840

gccaagaagg acacggattg gctgaaggag aaagtgcaga gcttgcagac gctggctgcc    900

aacaactctg cgttggccaa agccaacaac gacaccctgg aggatatgaa cagccagctc    960

aactcattca caggtcagat ggagaacatc accactatct ctcaagccaa cgagcagaac   1020

ctgaaagacc tgcaggactt acacaaagat gcagagaata gaacagccat caagttcaac   1080

caactggagg aacgcttcca gctctttgag acggatattg tgaacatcat tagcaatatc   1140

agttacacag cccaccacct gcggacgctg accagcaatc taaatgaagt caggaccact   1200

tgcacagata cccttaccaa acacacagat gatctgacct ccttgaataa taccctggcc   1260

aacatccgtt tggattctgt ttctctcagg atgcaacaag atttgatgag gtcgaggtta   1320

gacactgaag tagccaactt atcagtgatt atggaagaaa tgaagctagt agactccaag   1380

catggtcagc tcatcaagaa ttttacaata ctacaaggtc caccgggccc caggggtcca   1440

agaggtgaca gaggatccca gggaccccct ggcccaactg gcaacaaggg acagaaagga   1500

gagaaggggg agcctggacc acctggccct gcgggtgaga gaggcccaat tggaccagct   1560

ggtccccccg gagagcgtgg cggcaaagga tctaaaggct cccagggccc caaaggctcc   1620

cgtggttccc ctgggaagcc cggccctcag ggctccagtg gggacccagg ccccccgggc   1680

ccaccaggca aagagggact ccccggccct cagggccctc ctggcttcca gggacttcag   1740

ggcaccgttg gggagcctgg ggtgcctgga cctcggggac tgccaggctt gcctggggta   1800

ccaggcatgc caggccccaa gggccccccc ggccctcctg gcccatcagg agcggtggtg   1860

cccctggccc tgcagaatga gccaacccca gcaccggagg acaatggctg cccgcctcac   1920

tggaagaact tcacagacaa atgctactat ttttcagttg agaaagaaat ttttgaggat   1980

gcaaagcttt tctgtgaaga caagtcttca catcttgttt tcataaacac tagagaggaa   2040

cagcaatgga taaaaaaaca gatggtaggg agagagagcc actggatcgg cctcacagac   2100

tcagagcgtg aaaatgaatg gaagtggctg gatgggacat ctccagacta caaaaattgg   2160

aaagctggac agccggataa ctggggtcat ggccatgggc caggagaaga ctgtgctggg   2220

ttgatttatg ctgggcagtg gaacgatttc caatgtgaag acgtcaataa cttcatttgc   2280

gaaaaagaca gggagacagt actgtcatct gcattataac ggactgtgat gggatcacat   2340

gagcaaattt tcagctctca aaggcaaagg acactccttt ctaattgcat caccttctca   2400

tcagattgaa aaaaaaaaag cactgaaaac caattactga aaaaaaattg acagctagtg   2460

ttttttacca tccgtcatta cccaaagact tgggaactaa aatgttcccc agggtgatat   2520

gctgattttc attgtgcaca tggactgaat cacatagatt ctcctccgtc agtaaccgtg   2580

cgattataca aattatgtct tccaaagtat ggaacactcc aatcagaaaa aggttatcat   2640

tggtcgttga gttatgggaa gaacttaagc atatactgtg taaacagtgc catacatttc   2700

taaaatccca agtgtaggaa aaatatgcag acatacagat atataggcca actattagta   2760

ataatatgaa atatacttaa agagctttta aaactttgta tttttgtaca aaatatttgt   2820

cttttacaat ttttttcctt tttttttttt tgtcatttta ccgacataat acatggagcc   2880

aaagaaaaca ataatggtac taataaaaac tcctagggtt tcctgtcaga tttaattct    2939


<210>  3324
<211>  678
<212>  PRT
<213>  Homo sapiens

<400>  3324


Met Asp Asn Val Thr Gly Gly Met Glu Thr Ser Arg Gln Thr Tyr Asp 
1               5                   10                  15      


Asp Lys Leu Thr Ala Val Glu Ser Asp Leu Lys Lys Leu Gly Asp Gln 
            20                  25                  30          


Thr Gly Lys Lys Ala Ile Ser Thr Asn Ser Glu Leu Ser Thr Phe Arg 
        35                  40                  45              


Ser Asp Ile Leu Asp Leu Arg Gln Gln Leu Arg Glu Ile Thr Glu Lys 
    50                  55                  60                  


Thr Ser Lys Asn Lys Asp Thr Leu Glu Lys Leu Gln Ala Ser Gly Asp 
65                  70                  75                  80  


Ala Leu Val Asp Arg Gln Ser Gln Leu Lys Glu Thr Leu Glu Asn Asn 
                85                  90                  95      


Ser Phe Leu Ile Thr Thr Val Asn Lys Thr Leu Gln Ala Tyr Asn Gly 
            100                 105                 110         


Tyr Val Thr Asn Leu Gln Gln Asp Thr Ser Val Leu Gln Gly Asn Leu 
        115                 120                 125             


Gln Asn Gln Met Tyr Ser His Asn Val Val Ile Met Asn Leu Asn Asn 
    130                 135                 140                 


Leu Asn Leu Thr Gln Val Gln Gln Arg Asn Leu Ile Thr Asn Leu Gln 
145                 150                 155                 160 


Arg Ser Val Asp Asp Thr Ser Gln Ala Ile Gln Arg Ile Lys Asn Asp 
                165                 170                 175     


Phe Gln Asn Leu Gln Gln Val Phe Leu Gln Ala Lys Lys Asp Thr Asp 
            180                 185                 190         


Trp Leu Lys Glu Lys Val Gln Ser Leu Gln Thr Leu Ala Ala Asn Asn 
        195                 200                 205             


Ser Ala Leu Ala Lys Ala Asn Asn Asp Thr Leu Glu Asp Met Asn Ser 
    210                 215                 220                 


Gln Leu Asn Ser Phe Thr Gly Gln Met Glu Asn Ile Thr Thr Ile Ser 
225                 230                 235                 240 


Gln Ala Asn Glu Gln Asn Leu Lys Asp Leu Gln Asp Leu His Lys Asp 
                245                 250                 255     


Ala Glu Asn Arg Thr Ala Ile Lys Phe Asn Gln Leu Glu Glu Arg Phe 
            260                 265                 270         


Gln Leu Phe Glu Thr Asp Ile Val Asn Ile Ile Ser Asn Ile Ser Tyr 
        275                 280                 285             


Thr Ala His His Leu Arg Thr Leu Thr Ser Asn Leu Asn Glu Val Arg 
    290                 295                 300                 


Thr Thr Cys Thr Asp Thr Leu Thr Lys His Thr Asp Asp Leu Thr Ser 
305                 310                 315                 320 


Leu Asn Asn Thr Leu Ala Asn Ile Arg Leu Asp Ser Val Ser Leu Arg 
                325                 330                 335     


Met Gln Gln Asp Leu Met Arg Ser Arg Leu Asp Thr Glu Val Ala Asn 
            340                 345                 350         


Leu Ser Val Ile Met Glu Glu Met Lys Leu Val Asp Ser Lys His Gly 
        355                 360                 365             


Gln Leu Ile Lys Asn Phe Thr Ile Leu Gln Gly Pro Pro Gly Pro Arg 
    370                 375                 380                 


Gly Pro Arg Gly Asp Arg Gly Ser Gln Gly Pro Pro Gly Pro Thr Gly 
385                 390                 395                 400 


Asn Lys Gly Gln Lys Gly Glu Lys Gly Glu Pro Gly Pro Pro Gly Pro 
                405                 410                 415     


Ala Gly Glu Arg Gly Pro Ile Gly Pro Ala Gly Pro Pro Gly Glu Arg 
            420                 425                 430         


Gly Gly Lys Gly Ser Lys Gly Ser Gln Gly Pro Lys Gly Ser Arg Gly 
        435                 440                 445             


Ser Pro Gly Lys Pro Gly Pro Gln Gly Ser Ser Gly Asp Pro Gly Pro 
    450                 455                 460                 


Pro Gly Pro Pro Gly Lys Glu Gly Leu Pro Gly Pro Gln Gly Pro Pro 
465                 470                 475                 480 


Gly Phe Gln Gly Leu Gln Gly Thr Val Gly Glu Pro Gly Val Pro Gly 
                485                 490                 495     


Pro Arg Gly Leu Pro Gly Leu Pro Gly Val Pro Gly Met Pro Gly Pro 
            500                 505                 510         


Lys Gly Pro Pro Gly Pro Pro Gly Pro Ser Gly Ala Val Val Pro Leu 
        515                 520                 525             


Ala Leu Gln Asn Glu Pro Thr Pro Ala Pro Glu Asp Asn Gly Cys Pro 
    530                 535                 540                 


Pro His Trp Lys Asn Phe Thr Asp Lys Cys Tyr Tyr Phe Ser Val Glu 
545                 550                 555                 560 


Lys Glu Ile Phe Glu Asp Ala Lys Leu Phe Cys Glu Asp Lys Ser Ser 
                565                 570                 575     


His Leu Val Phe Ile Asn Thr Arg Glu Glu Gln Gln Trp Ile Lys Lys 
            580                 585                 590         


Gln Met Val Gly Arg Glu Ser His Trp Ile Gly Leu Thr Asp Ser Glu 
        595                 600                 605             


Arg Glu Asn Glu Trp Lys Trp Leu Asp Gly Thr Ser Pro Asp Tyr Lys 
    610                 615                 620                 


Asn Trp Lys Ala Gly Gln Pro Asp Asn Trp Gly His Gly His Gly Pro 
625                 630                 635                 640 


Gly Glu Asp Cys Ala Gly Leu Ile Tyr Ala Gly Gln Trp Asn Asp Phe 
                645                 650                 655     


Gln Cys Glu Asp Val Asn Asn Phe Ile Cys Glu Lys Asp Arg Glu Thr 
            660                 665                 670         


Val Leu Ser Ser Ala Leu 
        675             

<210>  3325
<211>  4260
<212>  DNA
<213>  Homo sapiens

<400>  3325
ggtattcagg aaggaacaca atgtaccaaa tgtaaaaata actgggcact gaagttttct     60

atcatattat tatacatttt gtgtgccttg ctaacaatca cagtagccat tttgggatat    120

aaagttgtag agaaaatgga caatgtcaca ggtggcatgg aaacatctcg ccaaacctat    180

gatgacaagc tcacagcagt ggaaagtgac ctgaaaaaat taggtgacca aactgggaag    240

aaagctatca gcaccaactc agaactctcc accttcagat cagacattct agatctccgt    300

cagcaacttc gtgagattac agaaaaaacc agcaagaaca aggatacgct ggagaagtta    360

caggcgagcg gggatgctct ggtggacagg cagagtcaat tgaaagaaac tttggagaat    420

aactctttcc tcatcaccac tgtaaacaaa accctccagg cgtataatgg ctatgtcacg    480

aatctgcagc aagataccag cgtgctccag ggcaatctgc agaaccaaat gtattctcat    540

aatgtggtca tcatgaacct caacaacctg aacctgaccc aggtgcagca gaggaacctc    600

atcacgaatc tgcagcggtc tgtggatgac acaagccagg ctatccagcg aatcaagaac    660

gactttcaaa atctgcagca ggtttttctt caagccaaga aggacacgga ttggctgaag    720

gagaaagtgc agagcttgca gacgctggct gccaacaact ctgcgttggc caaagccaac    780

aacgacaccc tggaggatat gaacagccag ctcaactcat tcacaggtca gatggagaac    840

atcaccacta tctctcaagc caacgagcag aacctgaaag acctgcagga cttacacaaa    900

gatgcagaga atagaacagc catcaagttc aaccaactgg aggaacgctt ccagctcttt    960

gagacggata ttgtgaacat cattagcaat atcagttaca cagcccacca cctgcggacg   1020

ctgaccagca atctaaatga agtcaggacc acttgcacag atacccttac caaacacaca   1080

gatgatctga cctccttgaa taataccctg gccaacatcc gtttggattc tgtttctctc   1140

aggatgcaac aagatttgat gaggtcgagg ttagacactg aagtagccaa cttatcagtg   1200

attatggaag aaatgaagct agtagactcc aagcatggtc agctcatcaa gaattttaca   1260

atactacaag gtccaccggg ccccaggggt ccaagaggtg acagaggatc ccagggaccc   1320

cctggcccaa ctggcaacaa gggacagaaa ggagagaagg gggagcctgg accacctggc   1380

cctgcgggtg agagaggccc aattggacca gctggtcccc ccggagagcg tggcggcaaa   1440

ggatctaaag gctcccaggg ccccaaaggc tcccgtggtt cccctgggaa gcccggccct   1500

cagggctcca gtggggaccc aggccccccg ggcccaccag gcaaagaggg actccccggc   1560

cctcagggcc ctcctggctt ccagggactt cagggcaccg ttggggagcc tggggtgcct   1620

ggacctcggg gactgccagg cttgcctggg gtaccaggca tgccaggccc caagggcccc   1680

cccggccctc ctggcccatc aggagcggtg gtgcccctgg ccctgcagaa tgagccaacc   1740

ccagcaccgg aggacaatgg taagtccaag ccctccctcc agccaggggg acagggcagt   1800

gcatgtgctt gagactgagc caacccccag tgtgtggccc cacccatgtt atttttgttt   1860

ttgtttttgt tttgagacag ggtctcactc tgttgcccag gctggagtgc agtggcgtga   1920

tctcggctca ctgcaacctc cacatcccgg gttcaagtga ttctcctgcc ttagcctccc   1980

aggtagctgg gactacaagc gtgtgccccc acagccagct aatttttgta tttttagtag   2040

agagggggtt tcaccgtgtt ggccaggctg gtctcaaact cctggcctca agtgatccac   2100

ctaccttagt ctcccaaagt gctgggatta caggtgtgag ccaccacgtc ttgtcccccg   2160

ctgcatatta tttaacagca aaggcatcat aggggctggc acaggagccc tgctgccaga   2220

acaggcctcc ataccaggca tgtgtttctc tctaaacgcc attgggttct ctagtgctca   2280

tttgttttat gtattatgtg tgtatgtatg ggacagggtc tcactctgtc acccaggctg   2340

gaatgacgaa gtgaagtagt gcaaacatag ctcactgcag ctttgacctc ctgggcttag   2400

gtgatcttcc cactcagact cctgcgtagc tgggaccaca ggggtatgcc accacacctg   2460

gctaattttt tattttcctt tttgtagaga cagggtcttg ctatgttgcc caggctggtc   2520

ttgaactcct ggcctcaagc aaccctcctg cctcagtctt gcaaagtgct gggattccag   2580

gtgggagcca ctgcacctgg ctcttgcact tgtttattta taggagccag ccctcagaag   2640

acaaacacaa tgcaaaacat ttccttcagg gaagcctgct ggccgccctg agcgctcttc   2700

cctcgtttta catcctcact ctggagatag atgggctccc tcggttagct ccatcaacat   2760

gtggatggaa ccctctgcta ttgatgacta catttaattt ctttttgaga aaggtgttag   2820

atgttacggt gccttctagt cttttgataa ttaaaccttt ggcaaaactc gaatgtttgg   2880

ttagcaacca agcctatttt tctctccttt gacccaaccg ctattctact tgattttggt   2940

cggtgaggcc cgggttattt ttgttgatcc gtgagcccag ttttggtgct gggttctcac   3000

atccaagtgt tcctgggttc cgtatgattc cagactgacg ctgaacatct gtgcctgccc   3060

tgcttcttgt tgttgcttct gttatttctg tcattgtgaa gacggatcca gacacagaag   3120

aacaaagacc cagtcaaaga tcttttccag attatgtggt tttggcttgt gctctgcagt   3180

ccactttggg tcatgcttgc tgcgagcacg tccgtgaacg tcagctgtgg gcctcgtgca   3240

gggacgctca ggctgctccc agcgggacca cagttttggc ctctgaaaca cagctgaaga   3300

aaggcagagt gctttctgtg atcttttaat caatgttttc cacttttgca ttcctaggct   3360

gcccgcctca ctggaagaac ttcacagaca aatgctacta tttttcagtt gagaaagaaa   3420

tttttgagga tgcaaagctt ttctgtgaag acaagtcttc acatcttgtt ttcataaaca   3480

ctagagagga acagcaatgg ataaaaaaac agatggtagg gagagagagc cactggatcg   3540

gcctcacaga ctcagagcgt gaaaatgaat ggaagtggct ggatgggaca tctccagact   3600

acaaaaattg gaaagctgga cagccggata actggggtca tggccatggg ccaggagaag   3660

actgtgctgg gttgatttat gctgggcagt ggaacgattt ccaatgtgaa gacgtcaata   3720

acttcatttg cgaaaaagac agggagacag tactgtcatc tgcattataa cggactgtga   3780

tgggatcaca tgagcaaatt ttcagctctc aaaggcaaag gacactcctt tctaattgca   3840

tcaccttctc atcagattga aaaaaaaaaa gcactgaaaa ccaattactg aaaaaaaatt   3900

gacagctagt gttttttacc atccgtcatt acccaaagac ttgggaacta aaatgttccc   3960

cagggtgata tgctgatttt cattgtgcac atggactgaa tcacatagat tctcctccgt   4020

cagtaaccgt gcgattatac aaattatgtc ttccaaagta tggaacactc caatcagaaa   4080

aaggttatca ttggtcgttg agttatggga agaacttaag catatactgt gtaaacagtg   4140

ccatacattt ctaaaatccc aagtgtagga aaaatatgca gacatacaga tatataggcc   4200

aactattagt aataatatga aatatactta aagagctttt aaaactttgt atttttgtac   4260


<210>  3326
<211>  558
<212>  PRT
<213>  Homo sapiens

<400>  3326


Met Asp Asn Val Thr Gly Gly Met Glu Thr Ser Arg Gln Thr Tyr Asp 
1               5                   10                  15      


Asp Lys Leu Thr Ala Val Glu Ser Asp Leu Lys Lys Leu Gly Asp Gln 
            20                  25                  30          


Thr Gly Lys Lys Ala Ile Ser Thr Asn Ser Glu Leu Ser Thr Phe Arg 
        35                  40                  45              


Ser Asp Ile Leu Asp Leu Arg Gln Gln Leu Arg Glu Ile Thr Glu Lys 
    50                  55                  60                  


Thr Ser Lys Asn Lys Asp Thr Leu Glu Lys Leu Gln Ala Ser Gly Asp 
65                  70                  75                  80  


Ala Leu Val Asp Arg Gln Ser Gln Leu Lys Glu Thr Leu Glu Asn Asn 
                85                  90                  95      


Ser Phe Leu Ile Thr Thr Val Asn Lys Thr Leu Gln Ala Tyr Asn Gly 
            100                 105                 110         


Tyr Val Thr Asn Leu Gln Gln Asp Thr Ser Val Leu Gln Gly Asn Leu 
        115                 120                 125             


Gln Asn Gln Met Tyr Ser His Asn Val Val Ile Met Asn Leu Asn Asn 
    130                 135                 140                 


Leu Asn Leu Thr Gln Val Gln Gln Arg Asn Leu Ile Thr Asn Leu Gln 
145                 150                 155                 160 


Arg Ser Val Asp Asp Thr Ser Gln Ala Ile Gln Arg Ile Lys Asn Asp 
                165                 170                 175     


Phe Gln Asn Leu Gln Gln Val Phe Leu Gln Ala Lys Lys Asp Thr Asp 
            180                 185                 190         


Trp Leu Lys Glu Lys Val Gln Ser Leu Gln Thr Leu Ala Ala Asn Asn 
        195                 200                 205             


Ser Ala Leu Ala Lys Ala Asn Asn Asp Thr Leu Glu Asp Met Asn Ser 
    210                 215                 220                 


Gln Leu Asn Ser Phe Thr Gly Gln Met Glu Asn Ile Thr Thr Ile Ser 
225                 230                 235                 240 


Gln Ala Asn Glu Gln Asn Leu Lys Asp Leu Gln Asp Leu His Lys Asp 
                245                 250                 255     


Ala Glu Asn Arg Thr Ala Ile Lys Phe Asn Gln Leu Glu Glu Arg Phe 
            260                 265                 270         


Gln Leu Phe Glu Thr Asp Ile Val Asn Ile Ile Ser Asn Ile Ser Tyr 
        275                 280                 285             


Thr Ala His His Leu Arg Thr Leu Thr Ser Asn Leu Asn Glu Val Arg 
    290                 295                 300                 


Thr Thr Cys Thr Asp Thr Leu Thr Lys His Thr Asp Asp Leu Thr Ser 
305                 310                 315                 320 


Leu Asn Asn Thr Leu Ala Asn Ile Arg Leu Asp Ser Val Ser Leu Arg 
                325                 330                 335     


Met Gln Gln Asp Leu Met Arg Ser Arg Leu Asp Thr Glu Val Ala Asn 
            340                 345                 350         


Leu Ser Val Ile Met Glu Glu Met Lys Leu Val Asp Ser Lys His Gly 
        355                 360                 365             


Gln Leu Ile Lys Asn Phe Thr Ile Leu Gln Gly Pro Pro Gly Pro Arg 
    370                 375                 380                 


Gly Pro Arg Gly Asp Arg Gly Ser Gln Gly Pro Pro Gly Pro Thr Gly 
385                 390                 395                 400 


Asn Lys Gly Gln Lys Gly Glu Lys Gly Glu Pro Gly Pro Pro Gly Pro 
                405                 410                 415     


Ala Gly Glu Arg Gly Pro Ile Gly Pro Ala Gly Pro Pro Gly Glu Arg 
            420                 425                 430         


Gly Gly Lys Gly Ser Lys Gly Ser Gln Gly Pro Lys Gly Ser Arg Gly 
        435                 440                 445             


Ser Pro Gly Lys Pro Gly Pro Gln Gly Ser Ser Gly Asp Pro Gly Pro 
    450                 455                 460                 


Pro Gly Pro Pro Gly Lys Glu Gly Leu Pro Gly Pro Gln Gly Pro Pro 
465                 470                 475                 480 


Gly Phe Gln Gly Leu Gln Gly Thr Val Gly Glu Pro Gly Val Pro Gly 
                485                 490                 495     


Pro Arg Gly Leu Pro Gly Leu Pro Gly Val Pro Gly Met Pro Gly Pro 
            500                 505                 510         


Lys Gly Pro Pro Gly Pro Pro Gly Pro Ser Gly Ala Val Val Pro Leu 
        515                 520                 525             


Ala Leu Gln Asn Glu Pro Thr Pro Ala Pro Glu Asp Asn Gly Lys Ser 
    530                 535                 540                 


Lys Pro Ser Leu Gln Pro Gly Gly Gln Gly Ser Ala Cys Ala 
545                 550                 555             

<210>  3327
<211>  654
<212>  DNA
<213>  Homo sapiens

<400>  3327
gagagcgcgc cctgaagccg ctccgagtgc ccaggtccct ctcgccgccg ccccggagcc     60

ccgtgctgcg cgccgaggcc gcctgcgccg tccgtgcgcc cccgcgcccc gcgccctctg    120

agccgccggc cgtccagggc acccaccccc agccccagcc cccgccggcc cgggatggcc    180

gcagcccgcg gctaagcgag cccggggggc cccatgggcc ggcccgcgcc gcaccccgcc    240

cgcggccgcc ccctccggcc cgggcccccc ccgggcaccg cgggcccagg cggcccggat    300

ggcggtcgcg gcggctgggg caggggctgg ggccgcgcgg ccgccactga cgggtagtcc    360

ggcgcccaca gcagctgcag ccgctccggc ctccttgctg ttcctgggat acgccacact    420

cagtctggcc tcggggcctt tgcactggct gtgtcccctg cctgtgatgc cattctcctc    480

tgcctggcca actcctacgt ttattcaagt ctggaccttg tcatcggctc ctcaggaagg    540

cactccggga cccccagatg ggggcggttc cctgtgactc ctggcacgga ggccaacccc    600

ttccttgttc aatggttcct tgagggacca ttcccatgtg attatcgacc attc          654


<210>  3328
<211>  92
<212>  PRT
<213>  Homo sapiens

<400>  3328


Met Ala Val Ala Ala Ala Gly Ala Gly Ala Gly Ala Ala Arg Pro Pro 
1               5                   10                  15      


Leu Thr Gly Ser Pro Ala Pro Thr Ala Ala Ala Ala Ala Pro Ala Ser 
            20                  25                  30          


Leu Leu Phe Leu Gly Tyr Ala Thr Leu Ser Leu Ala Ser Gly Pro Leu 
        35                  40                  45              


His Trp Leu Cys Pro Leu Pro Val Met Pro Phe Ser Ser Ala Trp Pro 
    50                  55                  60                  


Thr Pro Thr Phe Ile Gln Val Trp Thr Leu Ser Ser Ala Pro Gln Glu 
65                  70                  75                  80  


Gly Thr Pro Gly Pro Pro Asp Gly Gly Gly Ser Leu 
                85                  90          

<210>  3329
<211>  642
<212>  DNA
<213>  Homo sapiens

<400>  3329
cctggcctca agcaatcctc ctgccttggc ctcccaaagt gctgggatca aaggcatgag     60

ccaccttgcc cagccagtga gtgttttgaa tgaaggtgga agcgtccaag tgtgtgagtg    120

tggtcatgtt tgagtgtgac tgtgaaaacg ccctagcatg tgagcacgac gtattcaaat    180

gtgagtgtga gaacacacta gtggattcat gcggtggtgt tctggtgtgt ggatgtgatt    240

gtgttagaat atgtgagcct ggaaacatct gagtatgcat gggatcatgt ttgggtgtaa    300

gtatgaaaat actggctggg tgcagtggat cacacctgga atcccagtgc tttgggacca    360

aatgtgggag cgtttgagca cgcaagtgtg ctcgagtgag aatgcttgag catgtgagtg    420

tgatcgtgtg tgggcagtgt gtgagtgtgt gagtgtgtgt atacgagtat gaaagaacct    480

gagtgtgagg atatgagatg gctgggtgtg aatgagtgtg agtgggcaca caagtgtaag    540

cctgacagtg tgctgtgtga gatggggcat ctcgctatgt tgcccaggct ggtcttgaac    600

tcctgggctc tggcagctgt gggtgctggc agcgtgttca cc                       642


<210>  3330
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  3330


Met His Gly Ile Met Phe Gly Cys Lys Tyr Glu Asn Thr Gly Trp Val 
1               5                   10                  15      


Gln Trp Ile Thr Pro Gly Ile Pro Val Leu Trp Asp Gln Met Trp Glu 
            20                  25                  30          


Arg Leu Ser Thr Gln Val Cys Ser Ser Glu Asn Ala 
        35                  40                  

<210>  3331
<211>  1108
<212>  DNA
<213>  Homo sapiens

<400>  3331
atacgccaca ctcagtctgg cctcggggcc tttgcactgg ctgtgtcccc tgcctgtgat     60

gccattctcc tctgcctggc caactcctac gtttattcaa gtctggacct tgtcatcggc    120

tcctcaggaa ggcactccgg gacccccaga tgggggcggt tccctgtgac tcctggcacg    180

gaggccaacc ccttccttgt tcaatggttc cttgagggac cattcccatg tgattatcga    240

ccattcggca ggcgttcaaa gtcaaaggcc ccacactgag tcctggccca gcgccctgtg    300

cccgttggct gctggaggga cagacggggc gtgcggctga ccatcccgtg cccgcaggct    360

gaggatgcag cgctggaagg cggcggcctt ggcctcagtg ctctgcagct ccgtgctgtc    420

catctggatg tgtcgagagg gcctgcttct cagccaccgc ctcggacctg cgctggtccc    480

cctgcaccgc ctgcctcgaa ccctggacgc ccggattgcc cgcctggccc agtaccgtgc    540

actcctgcag ggggccccgg atgcgatgga gctgcgcgag ctgacgccct gggctgggcg    600

gcccccaggt ccgcgccgtc gggcggggcc ccggcggcgg cgcgcgcgtg cgcggttggg    660

ggcgcggcct tgcgggctgc gcgagctgga ggtgcgcgtg agcgagctgg gcctgggcta    720

cgcgtccgac gagacggtgc tgttccgcta ctgcgcaggc gcctgcgagg ctgccgcgcg    780

cgtctacgac ctcgggctgc gacgactgcg ccagcggcgg cgcctgcggc gggagcgggt    840

gcgcgcgcag ccctgctgcc gcccgacggc ctacgaggac gaggtgtcct tcctggacgc    900

gcacagccgc taccacacgg tgcacgagct gtcggcgcgc gagtgcgcct gcgtgtgacc    960

ctacctcact cggccggcgc ggcggccact ccccccgcct cgacggcacc actggccggc   1020

cccgcgaaag actgcgcgtg cgtagagcac gccggcgcgg ccccgggact ctcgcgataa   1080

ctgtactgag ataaagtgtg gcaactcg                                      1108


<210>  3332
<211>  197
<212>  PRT
<213>  Homo sapiens

<400>  3332


Met Gln Arg Trp Lys Ala Ala Ala Leu Ala Ser Val Leu Cys Ser Ser 
1               5                   10                  15      


Val Leu Ser Ile Trp Met Cys Arg Glu Gly Leu Leu Leu Ser His Arg 
            20                  25                  30          


Leu Gly Pro Ala Leu Val Pro Leu His Arg Leu Pro Arg Thr Leu Asp 
        35                  40                  45              


Ala Arg Ile Ala Arg Leu Ala Gln Tyr Arg Ala Leu Leu Gln Gly Ala 
    50                  55                  60                  


Pro Asp Ala Met Glu Leu Arg Glu Leu Thr Pro Trp Ala Gly Arg Pro 
65                  70                  75                  80  


Pro Gly Pro Arg Arg Arg Ala Gly Pro Arg Arg Arg Arg Ala Arg Ala 
                85                  90                  95      


Arg Leu Gly Ala Arg Pro Cys Gly Leu Arg Glu Leu Glu Val Arg Val 
            100                 105                 110         


Ser Glu Leu Gly Leu Gly Tyr Ala Ser Asp Glu Thr Val Leu Phe Arg 
        115                 120                 125             


Tyr Cys Ala Gly Ala Cys Glu Ala Ala Ala Arg Val Tyr Asp Leu Gly 
    130                 135                 140                 


Leu Arg Arg Leu Arg Gln Arg Arg Arg Leu Arg Arg Glu Arg Val Arg 
145                 150                 155                 160 


Ala Gln Pro Cys Cys Arg Pro Thr Ala Tyr Glu Asp Glu Val Ser Phe 
                165                 170                 175     


Leu Asp Ala His Ser Arg Tyr His Thr Val His Glu Leu Ser Ala Arg 
            180                 185                 190         


Glu Cys Ala Cys Val 
        195         

<210>  3333
<211>  1671
<212>  DNA
<213>  Homo sapiens

<400>  3333
atacgccaca ctcagtctgg cctcggggcc tttgcactgg ctgtgtcccc tgcctgtgat     60

gccattctcc tctgcctggc caactcctac gtttattcaa gtctggacct tgtcatcggc    120

tcctcaggaa ggcactccgg gacccccaga tgggggcggt tccctgtgac tcctggcacg    180

gaggccaacc ccttccttgt tcaatggttc cttgagggac cattcccatg tgattatcga    240

ccattcggca ggcgttcaaa gtcaaaggcc ccacactgag tcctggccca gcgccctgtg    300

cccgttggct gctggaggga cagacggggc gtgcggctga ccatcccgtg cccgcaggct    360

gaggatgcag cgctggaagg cggcggcctt ggcctcagtg ctctgcagct ccgtgctgtc    420

catctggatg tgtcgagagg gcctgcttct cagccaccgc ctcggacctg cgctggtccc    480

cctgcaccgc ctgcctcgaa ccctggacgc ccggattgcc cgcctggccc agtaccgtgc    540

actcctgcag ggggccccgg atgcgatgga gctgcgcgag ctgacgccct gggctgggcg    600

gcccccaggt ccgcgccgtc gggcggggcc ccggcggcgg cgcgcgcgtg cgcggttggg    660

ggcgcggcct tgcgggctgc gcgagctgga ggtgcgcgtg agcgagctgg gcctgggcta    720

cgcgtccgac gagacggtgc tgttccgcta ctgcgcaggc gcctgcgagg ctgccgcgcg    780

cgtctacgac ctcgggctgc gacgactgcg ccagcggcgg cgcctgcggc gggagcgggt    840

gcgcgcgcag ccctgctgcc gcccgacggc ctacgaggac gaggtgtcct tcctggacgc    900

gcacagccgc taccacacgg tgcacgagct gtcggcgcgc gagtgcgcct gcgtgtgacc    960

ctacctcact cggccggcgc ggcggccact ccccccgcct cgacggcacc actggccggc   1020

cccgcgaaag actgcgcgtg cgtagagcac gccggcgcgg ccccgggact ctcgcgataa   1080

ctgtactgag ataaagtgtg gcaactcgag ctggctggtg attcatcctc ggcgaggggc   1140

tcgcgtgtgg gccacgtcgc cgtctccacc gggaaagcgg ggaccagtgg ggggggccca   1200

gctgcagggt agtgggagga tgctgtttgc tttgggggaa gggtagatgc aaagtgggtc   1260

cagtttatgg cggacaaaaa ggaaaatggg gtgaatgggg ctatgttggc agggaccgtc   1320

cttcctgcct ccctacgggt ccctctgccc gtcccgagcg tgttccggtc cgcacctctt   1380

cgctgtgtgg gcttctgggg aggggaaagg gaagctacgc tcggatgaag agaccgaggt   1440

ctaggtggac cccgtttccc cagcttgttc ccttccgcac ctctccgcgg tgcgggcttc   1500

tgggatgaag acactgaagt ctaggtgggc ccagtttccc cagattgtcg ctgactgcac   1560

ctctcgcttc tgggatgaag agactgaggt ctaggtggac ccagtttccc cagcttgttc   1620

ctgactgcac ctctctgctg tgtggacttc tggagagggg gaaaggggga g            1671


<210>  3334
<211>  197
<212>  PRT
<213>  Homo sapiens

<400>  3334


Met Gln Arg Trp Lys Ala Ala Ala Leu Ala Ser Val Leu Cys Ser Ser 
1               5                   10                  15      


Val Leu Ser Ile Trp Met Cys Arg Glu Gly Leu Leu Leu Ser His Arg 
            20                  25                  30          


Leu Gly Pro Ala Leu Val Pro Leu His Arg Leu Pro Arg Thr Leu Asp 
        35                  40                  45              


Ala Arg Ile Ala Arg Leu Ala Gln Tyr Arg Ala Leu Leu Gln Gly Ala 
    50                  55                  60                  


Pro Asp Ala Met Glu Leu Arg Glu Leu Thr Pro Trp Ala Gly Arg Pro 
65                  70                  75                  80  


Pro Gly Pro Arg Arg Arg Ala Gly Pro Arg Arg Arg Arg Ala Arg Ala 
                85                  90                  95      


Arg Leu Gly Ala Arg Pro Cys Gly Leu Arg Glu Leu Glu Val Arg Val 
            100                 105                 110         


Ser Glu Leu Gly Leu Gly Tyr Ala Ser Asp Glu Thr Val Leu Phe Arg 
        115                 120                 125             


Tyr Cys Ala Gly Ala Cys Glu Ala Ala Ala Arg Val Tyr Asp Leu Gly 
    130                 135                 140                 


Leu Arg Arg Leu Arg Gln Arg Arg Arg Leu Arg Arg Glu Arg Val Arg 
145                 150                 155                 160 


Ala Gln Pro Cys Cys Arg Pro Thr Ala Tyr Glu Asp Glu Val Ser Phe 
                165                 170                 175     


Leu Asp Ala His Ser Arg Tyr His Thr Val His Glu Leu Ser Ala Arg 
            180                 185                 190         


Glu Cys Ala Cys Val 
        195         

<210>  3335
<211>  404
<212>  DNA
<213>  Homo sapiens

<400>  3335
gattcatcct cggcgagggg ctcgcgtgtg ggccacgtcg ccgtctccac cgggaaagcg     60

gggaccagtg gggggggccc agctgcaggg tagtgggagg atgctgtttg ctttggggga    120

agggtagatg caaagtgggt ccatttcccc agattgtcgc tgactgcacc tctcgcttct    180

gggatgaaga gactgaggtc taggtggacc cagtttcccc agcttgttcc tgactgcacc    240

tctctgctgt gtggacttct ggagaggggg aaagggggag acactgtggg tgaggagcct    300

gagatccagg tggaatcagt tccccagcgt ctccctgtcc gcactgatcc cgctatgtgg    360

gtttctagga agggggagcc actctggggg tgaggagagt gagg                     404


<210>  3336
<211>  69
<212>  PRT
<213>  Homo sapiens

<400>  3336


Met Lys Arg Leu Arg Ser Arg Trp Thr Gln Phe Pro Gln Leu Val Pro 
1               5                   10                  15      


Asp Cys Thr Ser Leu Leu Cys Gly Leu Leu Glu Arg Gly Lys Gly Gly 
            20                  25                  30          


Asp Thr Val Gly Glu Glu Pro Glu Ile Gln Val Glu Ser Val Pro Gln 
        35                  40                  45              


Arg Leu Pro Val Arg Thr Asp Pro Ala Met Trp Val Ser Arg Lys Gly 
    50                  55                  60                  


Glu Pro Leu Trp Gly 
65                  

<210>  3337
<211>  447
<212>  DNA
<213>  Homo sapiens

<400>  3337
acggggatta ggggagcccc acgatttgtt ttcaaaggat gtccgggctc caggacagga     60

tgccctgggt cacctgatga caggtgtggt ggttggaaag ggcctggttt cagctccggg    120

tacacttcct ccttccttct gctgcgtggt gtggcctctt ccacgtcctc agaatccagc    180

tgttactccg tccgcggcct ctcagctcta gggccctctg cacactggcc cccccagtgt    240

cacgggcatc cagacgggat ccagtgcatc ctcttttaga agaaaggcct gtctccagat    300

ccccgagtcc ctctagcatc tcccagaagg tgtcagacgc agcagtgtcc agggagcggc    360

agcaggtctg cactccaacc tgggcgacac agtgagactg tctcaagaaa aaaaaaaaaa    420

ggggggagtg tccctttctg agtgtgc                                        447


<210>  3338
<211>  44
<212>  PRT
<213>  Homo sapiens

<400>  3338


Met Thr Gly Val Val Val Gly Lys Gly Leu Val Ser Ala Pro Gly Thr 
1               5                   10                  15      


Leu Pro Pro Ser Phe Cys Cys Val Val Trp Pro Leu Pro Arg Pro Gln 
            20                  25                  30          


Asn Pro Ala Val Thr Pro Ser Ala Ala Ser Gln Leu 
        35                  40                  

<210>  3339
<211>  2910
<212>  DNA
<213>  Homo sapiens

<400>  3339
gtcaacctca ccagtcaagg aatgagacat gagtggaatt aggttgccac ttctggagct     60

ctgggagacc ccaaccccct ggcccatccc tacctcccag aacctcactg gtctgggcgt    120

ggctgggcac tgagatagta gaactcaggc agcatgatgc agcctcccag aaatgatttc    180

tagaacaggg cagtcgtgat acttggaggc tgggctttga gctcggtcac ctttgcaccc    240

agcttgggag tgagagagtt taaggtcatc ctccctcaaa accagtattc cagatcattt    300

ctctccattc caggaagttt gcatagctcc ctggacttct gctttgcact gccctgcagg    360

agtgggtggg gaaaggaagt ggctttgagg cacacagagg ggcttgttga ggccaccgga    420

ggaagcttct gccaccaata tgggacctgt gcccagccta ccagaagaga gcatctgaaa    480

acatgtatcg acatggtaac ccctctgctt gaagcctcac atggctccct attgccttgg    540

tgctgaacac cctatggctg accgtggccc agcctctgca acagctctgc ctcctctcca    600

gtgccttttc actttgtact caaagccaca tcgcattgaa gccacaggtg gggcaaggtc    660

atgcatgacc tgagtctcca aatcccttca ccctgtttgg ttctgcaacg gggattaggg    720

gagccccacg atttgttttc aaaggatgtc cgggctccag gacaggatgc cctgggtcac    780

ctgatgacag gtgtggtggt tggaaagggc ctggtttcag ctccgggtac acttcctcct    840

tccttctgct gcgtggtgtg gcctcttcca cgtcctcaga atccagctgt tactccgtcc    900

gcggcctctc agctctaggg ccctctgcac actggccccc ccagatactc tgacccatgg    960

atcccctggg cccggccaag ccacagtggt cgtggcgctg ctgtctgacc acgctgctgt   1020

ttcagctgct gatggctgtg tgtttcttct cctatctgcg tgtgtctcaa gacgatccca   1080

ctgtgtaccc taatgggtcc cgcttcccag acagcacagg gacccccgcc cactccatcc   1140

ccctgatcct gctgtggacg tggcctttta acaaacccat agctctgccc cgctgctcag   1200

agatggtgcc tggcacggct gactgcaaca tcactgccga ccgcaaggtg tatccacagg   1260

cagacgcggt catcgtgcac caccgagagg tcatgtacaa ccccagtgcc cagctcccac   1320

gctccccgag gcggcagggg cagcgatgga tctggttcag catggagtcc ccaagccact   1380

gctggcagct gaaagccatg gacggatact tcaatctcac catgtcctac cgcagcgact   1440

ccgacatctt cacgccctac ggctggctgg agccgtggtc cggccagcct gcccacccac   1500

cgctcaacct ctcggccaag accgagctgg tggcctgggc agtgtccaac tgggggccaa   1560

actccgccag ggtgcgctac taccagagcc tgcaggccca tctcaaggtg gacgtgtacg   1620

gacgctccca caagcccctg ccccagggaa ccatgatgga gacgctgtcc cggtacaagt   1680

tctatctggc cttcgagaac tccttgcacc ccgactacat caccgagaag ctgtggagga   1740

acgccctgga ggcctgggcc gtgcccgtgg tgctgggccc cagcagaagc aactacgaga   1800

ggttcctgcc acccgacgcc ttcatccacg tggacgactt ccagagcccc aaggacctgg   1860

cccggtacct gcaggagctg gacaaggacc acgcccgcta cctgagctac tttcgctggc   1920

gggagacgct gcggcctcgc tccttcagct gggcactcgc tttctgcaag gcctgctgga   1980

aactgcagga ggaatccagg taccagacac gcggcatagc ggcttggttc acctgagagg   2040

ctggtgtggg gcctgggctg ccaggaacct cattttcctg gggcctcacc tgagtggggg   2100

cctcatctac ctaaggactc gtttgcctga agcttcacct gcctgaggac tcacctgcct   2160

gggacggtca cctgttgcag cttcacctgc ctggggattc acctacctgg gtcctcactt   2220

tcctggggcc tcacctgctg gagtcttcgg tggccaggta tgtcccttac ctgggatttc   2280

acatgctggc ttccaggagc gtcccctgcg gaagcctggc ctgctgggga tgtctcctgg   2340

ggactttgcc tactggggac ctcggctgtt ggggacttta cctgctggga cctgctccca   2400

gagaccttcc acactgaatc tcacctgcta ggagcctcac ctgctgggga cctcaccctg   2460

gagggcactg ggccctggga actggcaccc atggggcccc acccatgagt gatggttctg   2520

gctgatttgt ttgtgatgtt gttagccgcc tgtgaggggt gcagagagat aatcaccgca   2580

ccgtttccag atgtaatact gcaaagaaaa ccgatgatga ggccgggtgc ggtggctcac   2640

acctgtaatc ccagcacttt gggaggccga ggcaggcgga tcacaaggtc aggagatcga   2700

gaccatcctg gccaatatgg tgaaacccgt ctctactaaa aatacaaaaa tttgccgggc   2760

gtggtggtgc atgcctgtaa tcccagctac ttgggaagct gaggcaggag aatcgcttga   2820

accagagagt cggaggttgc agtaagccga gatcgcgcca ctgcactcca gcctggcgac   2880

agagcgagac tctgtctcaa aaaaaaaaaa                                    2910


<210>  3340
<211>  50
<212>  PRT
<213>  Homo sapiens

<400>  3340


Met Ala Pro Tyr Cys Leu Gly Ala Glu His Pro Met Ala Asp Arg Gly 
1               5                   10                  15      


Pro Ala Ser Ala Thr Ala Leu Pro Pro Leu Gln Cys Leu Phe Thr Leu 
            20                  25                  30          


Tyr Ser Lys Pro His Arg Ile Glu Ala Thr Gly Gly Ala Arg Ser Cys 
        35                  40                  45              


Met Thr 
    50  

<210>  3341
<211>  3298
<212>  DNA
<213>  Homo sapiens

<400>  3341
gtcaacctca ccagtcaagg aatgagacat gagtggaatt aggttgccac ttctggagct     60

ctgggagacc ccaaccccct ggcccatccc tacctcccag aacctcactg gtctgggcgt    120

ggctgggcac tgagatagta gaactcaggc agcatgatgc agcctcccag aaatgatttc    180

tagaacaggg cagtcgtgat acttggaggc tgggctttga gctcggtcac ctttgcaccc    240

agcttgggag tgagagagtt taaggtcatc ctccctcaaa accagtattc cagatcattt    300

ctctccattc caggaagttt gcatagctcc ctggacttct gctttgcact gccctgcagg    360

agtgggtggg gaaaggaagt ggctttgagg cacacagagg ggcttgttga ggccaccgga    420

ggaagcttct gccaccaata tgggacctgt gcccagccta ccagaagaga gcatctgaaa    480

acatgtatcg acatggtaac ccctctgctt gaagcctcac atggctccct attgccttgg    540

tgctgaacac cctatggctg accgtggccc agcctctgca acagctctgc ctcctctcca    600

gtggtgaaga cccagcctgc tgagactcct cctgcagttc ctcaacatgc ctgcatttct    660

gctgcctcag ggcctttgcg aaggttgttc cttgtaactg gaatgccctt ccatcccttt    720

tttattcaaa aggctgcaat tttaattgaa gaaagttccc ttccaaggtt catgagttgc    780

ctgacttgcc caccggtttc ctgcaagatc ccttggcctg gcacttagtg ctcaggaaat    840

atttggtgat gggccaactg agtgagaagg tgggatctgg tgggaaggaa agcggaaagg    900

tagaaattct gctcacttcc tcattcccac ctcccaagga acccctggtg tccctgtgga    960

acccgctttg ggaaccggtg gttcaggtca gccttttcac tttgtactca aagccacatc   1020

gcattgaagc cacaggtggg gcaaggtcat gcatgacctg agtctccaaa tcccttcacc   1080

ctgtttggtt ctgcaacggg gattagggga gccccacgat ttgttttcaa aggatgtccg   1140

ggctccagga caggatgccc tgggtcacct gatgacaggt gtggtggttg gaaagggcct   1200

ggtttcagct ccgggtacac ttcctccttc cttctgctgc gtggtgtggc ctcttccacg   1260

tcctcagaat ccagctgtta ctccgtccgc ggcctctcag ctctagggcc ctctgcacac   1320

tggccccccc agatactctg acccatggat cccctgggcc cggccaagcc acagtggtcg   1380

tggcgctgct gtctgaccac gctgctgttt cagctgctga tggctgtgtg tttcttctcc   1440

tatctgcgtg tgtctcaaga cgatcccact gtgtacccta atgggtcccg cttcccagac   1500

agcacaggga cccccgccca ctccatcccc ctgatcctgc tgtggacgtg gccttttaac   1560

aaacccatag ctctgccccg ctgctcagag atggtgcctg gcacggctga ctgcaacatc   1620

actgccgacc gcaaggtgta tccacaggca gacgcggtca tcgtgcacca ccgagaggtc   1680

atgtacaacc ccagtgccca gctcccacgc tccccgaggc ggcaggggca gcgatggatc   1740

tggttcagca tggagtcccc aagccactgc tggcagctga aagccatgga cggatacttc   1800

aatctcacca tgtcctaccg cagcgactcc gacatcttca cgccctacgg ctggctggag   1860

ccgtggtccg gccagcctgc ccacccaccg ctcaacctct cggccaagac cgagctggtg   1920

gcctgggcag tgtccaactg ggggccaaac tccgccaggg tgcgctacta ccagagcctg   1980

caggcccatc tcaaggtgga cgtgtacgga cgctcccaca agcccctgcc ccagggaacc   2040

atgatggaga cgctgtcccg gtacaagttc tatctggcct tcgagaactc cttgcacccc   2100

gactacatca ccgagaagct gtggaggaac gccctggagg cctgggccgt gcccgtggtg   2160

ctgggcccca gcagaagcaa ctacgagagg ttcctgccac ccgacgcctt catccacgtg   2220

gacgacttcc agagccccaa ggacctggcc cggtacctgc aggagctgga caaggaccac   2280

gcccgctacc tgagctactt tcgctggcgg gagacgctgc ggcctcgctc cttcagctgg   2340

gcactcgctt tctgcaaggc ctgctggaaa ctgcaggagg aatccaggta ccagacacgc   2400

ggcatagcgg cttggttcac ctgagaggct ggtgtggggc ctgggctgcc aggaacctca   2460

ttttcctggg gcctcacctg agtgggggcc tcatctacct aaggactcgt ttgcctgaag   2520

cttcacctgc ctgaggactc acctgcctgg gacggtcacc tgttgcagct tcacctgcct   2580

ggggattcac ctacctgggt cctcactttc ctggggcctc acctgctgga gtcttcggtg   2640

gccaggtatg tcccttacct gggatttcac atgctggctt ccaggagcgt cccctgcgga   2700

agcctggcct gctggggatg tctcctgggg actttgccta ctggggacct cggctgttgg   2760

ggactttacc tgctgggacc tgctcccaga gaccttccac actgaatctc acctgctagg   2820

agcctcacct gctggggacc tcaccctgga gggcactggg ccctgggaac tggcacccat   2880

ggggccccac ccatgagtga tggttctggc tgatttgttt gtgatgttgt tagccgcctg   2940

tgaggggtgc agagagataa tcaccgcacc gtttccagat gtaatactgc aaagaaaacc   3000

gatgatgagg ccgggtgcgg tggctcacac ctgtaatccc agcactttgg gaggccgagg   3060

caggcggatc acaaggtcag gagatcgaga ccatcctggc caatatggtg aaacccgtct   3120

ctactaaaaa tacaaaaatt tgccgggcgt ggtggtgcat gcctgtaatc ccagctactt   3180

gggaagctga ggcaggagaa tcgcttgaac cagagagtcg gaggttgcag taagccgaga   3240

tcgcgccact gcactccagc ctggcgacag agcgagactc tgtctcaaaa aaaaaaaa     3298


<210>  3342
<211>  359
<212>  PRT
<213>  Homo sapiens

<400>  3342


Met Asp Pro Leu Gly Pro Ala Lys Pro Gln Trp Ser Trp Arg Cys Cys 
1               5                   10                  15      


Leu Thr Thr Leu Leu Phe Gln Leu Leu Met Ala Val Cys Phe Phe Ser 
            20                  25                  30          


Tyr Leu Arg Val Ser Gln Asp Asp Pro Thr Val Tyr Pro Asn Gly Ser 
        35                  40                  45              


Arg Phe Pro Asp Ser Thr Gly Thr Pro Ala His Ser Ile Pro Leu Ile 
    50                  55                  60                  


Leu Leu Trp Thr Trp Pro Phe Asn Lys Pro Ile Ala Leu Pro Arg Cys 
65                  70                  75                  80  


Ser Glu Met Val Pro Gly Thr Ala Asp Cys Asn Ile Thr Ala Asp Arg 
                85                  90                  95      


Lys Val Tyr Pro Gln Ala Asp Ala Val Ile Val His His Arg Glu Val 
            100                 105                 110         


Met Tyr Asn Pro Ser Ala Gln Leu Pro Arg Ser Pro Arg Arg Gln Gly 
        115                 120                 125             


Gln Arg Trp Ile Trp Phe Ser Met Glu Ser Pro Ser His Cys Trp Gln 
    130                 135                 140                 


Leu Lys Ala Met Asp Gly Tyr Phe Asn Leu Thr Met Ser Tyr Arg Ser 
145                 150                 155                 160 


Asp Ser Asp Ile Phe Thr Pro Tyr Gly Trp Leu Glu Pro Trp Ser Gly 
                165                 170                 175     


Gln Pro Ala His Pro Pro Leu Asn Leu Ser Ala Lys Thr Glu Leu Val 
            180                 185                 190         


Ala Trp Ala Val Ser Asn Trp Gly Pro Asn Ser Ala Arg Val Arg Tyr 
        195                 200                 205             


Tyr Gln Ser Leu Gln Ala His Leu Lys Val Asp Val Tyr Gly Arg Ser 
    210                 215                 220                 


His Lys Pro Leu Pro Gln Gly Thr Met Met Glu Thr Leu Ser Arg Tyr 
225                 230                 235                 240 


Lys Phe Tyr Leu Ala Phe Glu Asn Ser Leu His Pro Asp Tyr Ile Thr 
                245                 250                 255     


Glu Lys Leu Trp Arg Asn Ala Leu Glu Ala Trp Ala Val Pro Val Val 
            260                 265                 270         


Leu Gly Pro Ser Arg Ser Asn Tyr Glu Arg Phe Leu Pro Pro Asp Ala 
        275                 280                 285             


Phe Ile His Val Asp Asp Phe Gln Ser Pro Lys Asp Leu Ala Arg Tyr 
    290                 295                 300                 


Leu Gln Glu Leu Asp Lys Asp His Ala Arg Tyr Leu Ser Tyr Phe Arg 
305                 310                 315                 320 


Trp Arg Glu Thr Leu Arg Pro Arg Ser Phe Ser Trp Ala Leu Ala Phe 
                325                 330                 335     


Cys Lys Ala Cys Trp Lys Leu Gln Glu Glu Ser Arg Tyr Gln Thr Arg 
            340                 345                 350         


Gly Ile Ala Ala Trp Phe Thr 
        355                 

<210>  3343
<211>  2211
<212>  DNA
<213>  Homo sapiens

<400>  3343
gcctcttcca cgtcctcaga atccagctgt tactccgtcc gcggcctctc agctctaggg     60

ccctctgcac actggccccc ccagtgtcac gggcatccag acgggatcca gtgcatcctc    120

ttttagaaga aaggcctgtc tccagatccc cgagtccctc tagcatctcc cagaaggtgt    180

cagacgcagc agtgtccagg gagcggcagc agattgagga agagtctggg gacacaccag    240

aaaaggacag gatcaagata ctctgaccca tggatcccct gggcccggcc aagccacagt    300

ggtcgtggcg ctgctgtctg accacgctgc tgtttcagct gctgatggct gtgtgtttct    360

tctcctatct gcgtgtgtct caagacgatc ccactgtgta ccctaatggg tcccgcttcc    420

cagacagcac agggaccccc gcccactcca tccccctgat cctgctgtgg acgtggcctt    480

ttaacaaacc catagctctg ccccgctgct cagagatggt gcctggcacg gctgactgca    540

acatcactgc cgaccgcaag gtgtatccac aggcagacgc ggtcatcgtg caccaccgag    600

aggtcatgta caaccccagt gcccagctcc cacgctcccc gaggcggcag gggcagcgat    660

ggatctggtt cagcatggag tccccaagcc actgctggca gctgaaagcc atggacggat    720

acttcaatct caccatgtcc taccgcagcg actccgacat cttcacgccc tacggctggc    780

tggagccgtg gtccggccag cctgcccacc caccgctcaa cctctcggcc aagaccgagc    840

tggtggcctg ggcagtgtcc aactgggggc caaactccgc cagggtgcgc tactaccaga    900

gcctgcaggc ccatctcaag gtggacgtgt acggacgctc ccacaagccc ctgccccagg    960

gaaccatgat ggagacgctg tcccggtaca agttctatct ggccttcgag aactccttgc   1020

accccgacta catcaccgag aagctgtgga ggaacgccct ggaggcctgg gccgtgcccg   1080

tggtgctggg ccccagcaga agcaactacg agaggttcct gccacccgac gccttcatcc   1140

acgtggacga cttccagagc cccaaggacc tggcccggta cctgcaggag ctggacaagg   1200

accacgcccg ctacctgagc tactttcgct ggcgggagac gctgcggcct cgctccttca   1260

gctgggcact cgctttctgc aaggcctgct ggaaactgca ggaggaatcc aggtaccaga   1320

cacgcggcat agcggcttgg ttcacctgag aggctggtgt ggggcctggg ctgccaggaa   1380

cctcattttc ctggggcctc acctgagtgg gggcctcatc tacctaagga ctcgtttgcc   1440

tgaagcttca cctgcctgag gactcacctg cctgggacgg tcacctgttg cagcttcacc   1500

tgcctgggga ttcacctacc tgggtcctca ctttcctggg gcctcacctg ctggagtctt   1560

cggtggccag gtatgtccct tacctgggat ttcacatgct ggcttccagg agcgtcccct   1620

gcggaagcct ggcctgctgg ggatgtctcc tggggacttt gcctactggg gacctcggct   1680

gttggggact ttacctgctg ggacctgctc ccagagacct tccacactga atctcacctg   1740

ctaggagcct cacctgctgg ggacctcacc ctggagggca ctgggccctg ggaactggca   1800

cccatggggc cccacccatg agtgatggtt ctggctgatt tgtttgtgat gttgttagcc   1860

gcctgtgagg ggtgcagaga gataatcacc gcaccgtttc cagatgtaat actgcaaaga   1920

aaaccgatga tgaggccggg tgcggtggct cacacctgta atcccagcac tttgggaggc   1980

cgaggcaggc ggatcacaag gtcaggagat cgagaccatc ctggccaata tggtgaaacc   2040

cgtctctact aaaaatacaa aaatttgccg ggcgtggtgg tgcatgcctg taatcccagc   2100

tacttgggaa gctgaggcag gagaatcgct tgaaccagag agtcggaggt tgcagtaagc   2160

cgagatcgcg ccactgcact ccagcctggc gacagagcga gactctgtct c            2211


<210>  3344
<211>  359
<212>  PRT
<213>  Homo sapiens

<400>  3344


Met Asp Pro Leu Gly Pro Ala Lys Pro Gln Trp Ser Trp Arg Cys Cys 
1               5                   10                  15      


Leu Thr Thr Leu Leu Phe Gln Leu Leu Met Ala Val Cys Phe Phe Ser 
            20                  25                  30          


Tyr Leu Arg Val Ser Gln Asp Asp Pro Thr Val Tyr Pro Asn Gly Ser 
        35                  40                  45              


Arg Phe Pro Asp Ser Thr Gly Thr Pro Ala His Ser Ile Pro Leu Ile 
    50                  55                  60                  


Leu Leu Trp Thr Trp Pro Phe Asn Lys Pro Ile Ala Leu Pro Arg Cys 
65                  70                  75                  80  


Ser Glu Met Val Pro Gly Thr Ala Asp Cys Asn Ile Thr Ala Asp Arg 
                85                  90                  95      


Lys Val Tyr Pro Gln Ala Asp Ala Val Ile Val His His Arg Glu Val 
            100                 105                 110         


Met Tyr Asn Pro Ser Ala Gln Leu Pro Arg Ser Pro Arg Arg Gln Gly 
        115                 120                 125             


Gln Arg Trp Ile Trp Phe Ser Met Glu Ser Pro Ser His Cys Trp Gln 
    130                 135                 140                 


Leu Lys Ala Met Asp Gly Tyr Phe Asn Leu Thr Met Ser Tyr Arg Ser 
145                 150                 155                 160 


Asp Ser Asp Ile Phe Thr Pro Tyr Gly Trp Leu Glu Pro Trp Ser Gly 
                165                 170                 175     


Gln Pro Ala His Pro Pro Leu Asn Leu Ser Ala Lys Thr Glu Leu Val 
            180                 185                 190         


Ala Trp Ala Val Ser Asn Trp Gly Pro Asn Ser Ala Arg Val Arg Tyr 
        195                 200                 205             


Tyr Gln Ser Leu Gln Ala His Leu Lys Val Asp Val Tyr Gly Arg Ser 
    210                 215                 220                 


His Lys Pro Leu Pro Gln Gly Thr Met Met Glu Thr Leu Ser Arg Tyr 
225                 230                 235                 240 


Lys Phe Tyr Leu Ala Phe Glu Asn Ser Leu His Pro Asp Tyr Ile Thr 
                245                 250                 255     


Glu Lys Leu Trp Arg Asn Ala Leu Glu Ala Trp Ala Val Pro Val Val 
            260                 265                 270         


Leu Gly Pro Ser Arg Ser Asn Tyr Glu Arg Phe Leu Pro Pro Asp Ala 
        275                 280                 285             


Phe Ile His Val Asp Asp Phe Gln Ser Pro Lys Asp Leu Ala Arg Tyr 
    290                 295                 300                 


Leu Gln Glu Leu Asp Lys Asp His Ala Arg Tyr Leu Ser Tyr Phe Arg 
305                 310                 315                 320 


Trp Arg Glu Thr Leu Arg Pro Arg Ser Phe Ser Trp Ala Leu Ala Phe 
                325                 330                 335     


Cys Lys Ala Cys Trp Lys Leu Gln Glu Glu Ser Arg Tyr Gln Thr Arg 
            340                 345                 350         


Gly Ile Ala Ala Trp Phe Thr 
        355                 

<210>  3345
<211>  2926
<212>  DNA
<213>  Homo sapiens

<400>  3345
agatcatttc tctccattcc aggaagtttg catagctccc tggacttctg ctttgcactg     60

ccctgcagga gtgggtgggg aaaggaagtg gctttgaggc acacagaggg gcttgttgag    120

gccaccggag gaagcttctg ccaccaatat gggacctgtg cccagcctac cagaagagag    180

catctgaaaa catgtatcga catggtaacc cctctgcttg aagcctcaca tggctcccta    240

ttgccttggt gctgaacacc ctatggctga ccgtggccca gcctctgcaa cagctctgcc    300

tcctctccag tggtgaagac ccagcctgct gagactcctc ctgcagttcc tcaacatgcc    360

tgcatttctg ctgcctcagg gcctttgcga aggttgttcc ttgtaactgg aatgcccttc    420

catccctttt ttattcaaaa ggctgcaatt ttaattgaag aaagttccct tccaaggttc    480

atgagttgcc tgacttgccc accggtttcc tgcaagatcc cttggcctgg cacttagtgc    540

tcaggaaata tttggtgatg ggccaactga gtgagaaggt gggatctggt gggaaggaaa    600

gcggaaaggt agaaattctg ctcacttcct cattcccacc tcccaaggaa cccctggtgt    660

ccctgtggaa cccgctttgg gaaccggtgg ttcaggtcag ccttttcact ttgtactcaa    720

agccacatcg cattgaagcc acaggtgggg caaggtcatg catgacctga gtctccaaat    780

cccttcaccc tgtttggttc tgcaacgggg attaggggag ccccacgatt tgttttcaaa    840

ggatgtccgg gctccaggac aggatgccct gggtcacctg atgacaggtg tggtggttgg    900

aaagggcctg gtttcagctc cgggtacact tcctccttcc ttctgctgcg tggtgtggcc    960

tcttccacgt cctcagaatc cagctgttac tccgtccgcg gcctctcagc tctagggccc   1020

tctgcacact ggccccccca gatactctga cccatggatc ccctgggccc ggccaagcca   1080

cagtggtcgt ggcgctgctg tctgaccacg ctgctgtttc agctgctgat ggctgtgtgt   1140

ttcttctcct atctgcgtgt gtctcaagac gatcccactg tgtaccctaa tgggtcccgc   1200

ttcccagaca gcacagggac ccccgcccac tccatccccc tgatcctgct gtggacgtgg   1260

ccttttaaca aacccatagc tctgccccgc tgctcagaga tggtgcacca ccgagaggtc   1320

atgtacaacc ccagtgccca gctcccacgc tccccgaggc ggcaggggca gcgatggatc   1380

tggttcagca tggagtcccc aagccactgc tggcagctga aagccatgga cggatacttc   1440

aatctcacca tgtcctaccg cagcgactcc gacatcttca cgccctacgg ctggctggag   1500

ccgtggtccg gccagcctgc ccacccaccg ctcaacctct cggccaagac cgagctggtg   1560

gcctgggcag tgtccaactg ggggccaaac tccgccaggg tgcgctacta ccagagcctg   1620

caggcccatc tcaaggtgga cgtgtacgga cgctcccaca agcccctgcc ccagggaacc   1680

atgatggaga cgctgtcccg gtacaagttc tatctggcct tcgagaactc cttgcacccc   1740

gactacatca ccgagaagct gtggaggaac gccctggagg cctgggccgt gcccgtggtg   1800

ctgggcccca gcagaagcaa ctacgagagg ttcctgccac ccgacgcctt catccacgtg   1860

gacgacttcc agagccccaa ggacctggcc cggtacctgc aggagctgga caaggaccac   1920

gcccgctacc tgagctactt tcgctggcgg gagacgctgc ggcctcgctc cttcagctgg   1980

gcactcgctt tctgcaaggc ctgctggaaa ctgcaggagg aatccaggta ccagacacgc   2040

ggcatagcgg cttggttcac ctgagaggct ggtgtggggc ctgggctgcc aggaacctca   2100

ttttcctggg gcctcacctg agtgggggcc tcatctacct aaggactcgt ttgcctgaag   2160

cttcacctgc ctgaggactc acctgcctgg gacggtcacc tgttgcagct tcacctgcct   2220

ggggattcac ctacctgggt cctcactttc ctggggcctc acctgctgga gtcttcggtg   2280

gccaggtatg tcccttacct gggatttcac atgctggctt ccaggagcgt cccctgcgga   2340

agcctggcct gctggggatg tctcctgggg actttgccta ctggggacct cggctgttgg   2400

ggactttacc tgctgggacc tgctcccaga gaccttccac actgaatctc acctgctagg   2460

agcctcacct gctggggacc tcaccctgga gggcactggg ccctgggaac tggcacccat   2520

ggggccccac ccatgagtga tggttctggc tgatttgttt gtgatgttgt tagccgcctg   2580

tgaggggtgc agagagataa tcaccgcacc gtttccagat gtaatactgc aaagaaaacc   2640

gatgatgagg ccgggtgcgg tggctcacac ctgtaatccc agcactttgg gaggccgagg   2700

caggcggatc acaaggtcag gagatcgaga ccatcctggc caatatggtg aaacccgtct   2760

ctactaaaaa tacaaaaatt tgccgggcgt ggtggtgcat gcctgtaatc ccagctactt   2820

gggaagctga ggcaggagaa tcgcttgaac cagagagtcg gaggttgcag taagccgaga   2880

tcgcgccact gcactccagc ctggcgacag agcgagactc tgtctc                  2926


<210>  3346
<211>  336
<212>  PRT
<213>  Homo sapiens

<400>  3346


Met Asp Pro Leu Gly Pro Ala Lys Pro Gln Trp Ser Trp Arg Cys Cys 
1               5                   10                  15      


Leu Thr Thr Leu Leu Phe Gln Leu Leu Met Ala Val Cys Phe Phe Ser 
            20                  25                  30          


Tyr Leu Arg Val Ser Gln Asp Asp Pro Thr Val Tyr Pro Asn Gly Ser 
        35                  40                  45              


Arg Phe Pro Asp Ser Thr Gly Thr Pro Ala His Ser Ile Pro Leu Ile 
    50                  55                  60                  


Leu Leu Trp Thr Trp Pro Phe Asn Lys Pro Ile Ala Leu Pro Arg Cys 
65                  70                  75                  80  


Ser Glu Met Val His His Arg Glu Val Met Tyr Asn Pro Ser Ala Gln 
                85                  90                  95      


Leu Pro Arg Ser Pro Arg Arg Gln Gly Gln Arg Trp Ile Trp Phe Ser 
            100                 105                 110         


Met Glu Ser Pro Ser His Cys Trp Gln Leu Lys Ala Met Asp Gly Tyr 
        115                 120                 125             


Phe Asn Leu Thr Met Ser Tyr Arg Ser Asp Ser Asp Ile Phe Thr Pro 
    130                 135                 140                 


Tyr Gly Trp Leu Glu Pro Trp Ser Gly Gln Pro Ala His Pro Pro Leu 
145                 150                 155                 160 


Asn Leu Ser Ala Lys Thr Glu Leu Val Ala Trp Ala Val Ser Asn Trp 
                165                 170                 175     


Gly Pro Asn Ser Ala Arg Val Arg Tyr Tyr Gln Ser Leu Gln Ala His 
            180                 185                 190         


Leu Lys Val Asp Val Tyr Gly Arg Ser His Lys Pro Leu Pro Gln Gly 
        195                 200                 205             


Thr Met Met Glu Thr Leu Ser Arg Tyr Lys Phe Tyr Leu Ala Phe Glu 
    210                 215                 220                 


Asn Ser Leu His Pro Asp Tyr Ile Thr Glu Lys Leu Trp Arg Asn Ala 
225                 230                 235                 240 


Leu Glu Ala Trp Ala Val Pro Val Val Leu Gly Pro Ser Arg Ser Asn 
                245                 250                 255     


Tyr Glu Arg Phe Leu Pro Pro Asp Ala Phe Ile His Val Asp Asp Phe 
            260                 265                 270         


Gln Ser Pro Lys Asp Leu Ala Arg Tyr Leu Gln Glu Leu Asp Lys Asp 
        275                 280                 285             


His Ala Arg Tyr Leu Ser Tyr Phe Arg Trp Arg Glu Thr Leu Arg Pro 
    290                 295                 300                 


Arg Ser Phe Ser Trp Ala Leu Ala Phe Cys Lys Ala Cys Trp Lys Leu 
305                 310                 315                 320 


Gln Glu Glu Ser Arg Tyr Gln Thr Arg Gly Ile Ala Ala Trp Phe Thr 
                325                 330                 335     

<210>  3347
<211>  3414
<212>  DNA
<213>  Homo sapiens

<400>  3347
gtcaacctca ccagtcaagg aatgagacat gagtggaatt aggttgccac ttctggagct     60

ctgggagacc ccaaccccct ggcccatccc tacctcccag aacctcactg gtctgggcgt    120

ggctgggcac tgagatagta gaactcaggc agcatgatgc agcctcccag aaatgatttc    180

tagaacaggg cagtcgtgat acttggaggc tgggctttga gctcggtcac ctttgcaccc    240

agcttgggag tgagagagtt taaggtcatc ctccctcaaa accagtattc cagatcattt    300

ctctccattc caggaagttt gcatagctcc ctggacttct gctttgcact gccctgcagg    360

agtgggtggg gaaaggaagt ggctttgagg cacacagagg ggcttgttga ggccaccgga    420

ggaagcttct gccaccaata tgggacctgt gcccagccta ccagaagaga gcatctgaaa    480

acatgtatcg acatggtaac ccctctgctt gaagcctcac atggctccct attgccttgg    540

tgctgaacac cctatggctg accgtggccc agcctctgca acagctctgc ctcctctcca    600

gtggtgaaga cccagcctgc tgagactcct cctgcagttc ctcaacatgc ctgcatttct    660

gctgcctcag ggcctttgcg aaggttgttc cttgtaactg gaatgccctt ccatcccttt    720

tttattcaaa aggctgcaat tttaattgaa gaaagttccc ttccaaggtt catgagttgc    780

ctgacttgcc caccggtttc ctgcaagatc ccttggcctg gcacttagtg ctcaggaaat    840

atttggtgat gggccaactg agtgagaagg tgggatctgg tgggaaggaa agcggaaagg    900

tagaaattct gctcacttcc tcattcccac ctcccaagga acccctggtg tccctgtgga    960

acccgctttg ggaaccggtg gttcaggtca gccttttcac tttgtactca aagccacatc   1020

gcattgaagc cacaggtggg gcaaggtcat gcatgacctg agtctccaaa tcccttcacc   1080

ctgtttggtt ctgcaacggg gattagggga gccccacgat ttgttttcaa aggatgtccg   1140

ggctccagga caggatgccc tgggtcacct gatgacaggt gtggtggttg gaaagggcct   1200

ggtttcagct ccgggtacac ttcctccttc cttctgctgc gtggtgtggc ctcttccacg   1260

tcctcagaat ccagctgtta ctccgtccgc ggcctctcag ctctagggcc ctctgcacac   1320

tggccccccc agtgtcacgg gcatccagac gggatccagt gcatcctctt ttagaagaaa   1380

ggcctgtctc cagatccccg agtccctcta gcatctccca gaaggtgtca gacgcagcag   1440

tgtccaggga gcggcagcag atactctgac ccatggatcc cctgggcccg gccaagccac   1500

agtggtcgtg gcgctgctgt ctgaccacgc tgctgtttca gctgctgatg gctgtgtgtt   1560

tcttctccta tctgcgtgtg tctcaagacg atcccactgt gtaccctaat gggtcccgct   1620

tcccagacag cacagggacc cccgcccact ccatccccct gatcctgctg tggacgtggc   1680

cttttaacaa acccatagct ctgccccgct gctcagagat ggtgcctggc acggctgact   1740

gcaacatcac tgccgaccgc aaggtgtatc cacaggcaga cgcggtcatc gtgcaccacc   1800

gagaggtcat gtacaacccc agtgcccagc tcccacgctc cccgaggcgg caggggcagc   1860

gatggatctg gttcagcatg gagtccccaa gccactgctg gcagctgaaa gccatggacg   1920

gatacttcaa tctcaccatg tcctaccgca gcgactccga catcttcacg ccctacggct   1980

ggctggagcc gtggtccggc cagcctgccc acccaccgct caacctctcg gccaagaccg   2040

agctggtggc ctgggcagtg tccaactggg ggccaaactc cgccagggtg cgctactacc   2100

agagcctgca ggcccatctc aaggtggacg tgtacggacg ctcccacaag cccctgcccc   2160

agggaaccat gatggagacg ctgtcccggt acaagttcta tctggccttc gagaactcct   2220

tgcaccccga ctacatcacc gagaagctgt ggaggaacgc cctggaggcc tgggccgtgc   2280

ccgtggtgct gggccccagc agaagcaact acgagaggtt cctgccaccc gacgccttca   2340

tccacgtgga cgacttccag agccccaagg acctggcccg gtacctgcag gagctggaca   2400

aggaccacgc ccgctacctg agctactttc gctggcggga gacgctgcgg cctcgctcct   2460

tcagctgggc actcgctttc tgcaaggcct gctggaaact gcaggaggaa tccaggtacc   2520

agacacgcgg catagcggct tggttcacct gagaggctgg tgtggggcct gggctgccag   2580

gaacctcatt ttcctggggc ctcacctgag tgggggcctc atctacctaa ggactcgttt   2640

gcctgaagct tcacctgcct gaggactcac ctgcctggga cggtcacctg ttgcagcttc   2700

acctgcctgg ggattcacct acctgggtcc tcactttcct ggggcctcac ctgctggagt   2760

cttcggtggc caggtatgtc ccttacctgg gatttcacat gctggcttcc aggagcgtcc   2820

cctgcggaag cctggcctgc tggggatgtc tcctggggac tttgcctact ggggacctcg   2880

gctgttgggg actttacctg ctgggacctg ctcccagaga ccttccacac tgaatctcac   2940

ctgctaggag cctcacctgc tggggacctc accctggagg gcactgggcc ctgggaactg   3000

gcacccatgg ggccccaccc atgagtgatg gttctggctg atttgtttgt gatgttgtta   3060

gccgcctgtg aggggtgcag agagataatc accgcaccgt ttccagatgt aatactgcaa   3120

agaaaaccga tgatgaggcc gggtgcggtg gctcacacct gtaatcccag cactttggga   3180

ggccgaggca ggcggatcac aaggtcagga gatcgagacc atcctggcca atatggtgaa   3240

acccgtctct actaaaaata caaaaatttg ccgggcgtgg tggtgcatgc ctgtaatccc   3300

agctacttgg gaagctgagg caggagaatc gcttgaacca gagagtcgga ggttgcagta   3360

agccgagatc gcgccactgc actccagcct ggcgacagag cgagactctg tctc         3414


<210>  3348
<211>  359
<212>  PRT
<213>  Homo sapiens

<400>  3348


Met Asp Pro Leu Gly Pro Ala Lys Pro Gln Trp Ser Trp Arg Cys Cys 
1               5                   10                  15      


Leu Thr Thr Leu Leu Phe Gln Leu Leu Met Ala Val Cys Phe Phe Ser 
            20                  25                  30          


Tyr Leu Arg Val Ser Gln Asp Asp Pro Thr Val Tyr Pro Asn Gly Ser 
        35                  40                  45              


Arg Phe Pro Asp Ser Thr Gly Thr Pro Ala His Ser Ile Pro Leu Ile 
    50                  55                  60                  


Leu Leu Trp Thr Trp Pro Phe Asn Lys Pro Ile Ala Leu Pro Arg Cys 
65                  70                  75                  80  


Ser Glu Met Val Pro Gly Thr Ala Asp Cys Asn Ile Thr Ala Asp Arg 
                85                  90                  95      


Lys Val Tyr Pro Gln Ala Asp Ala Val Ile Val His His Arg Glu Val 
            100                 105                 110         


Met Tyr Asn Pro Ser Ala Gln Leu Pro Arg Ser Pro Arg Arg Gln Gly 
        115                 120                 125             


Gln Arg Trp Ile Trp Phe Ser Met Glu Ser Pro Ser His Cys Trp Gln 
    130                 135                 140                 


Leu Lys Ala Met Asp Gly Tyr Phe Asn Leu Thr Met Ser Tyr Arg Ser 
145                 150                 155                 160 


Asp Ser Asp Ile Phe Thr Pro Tyr Gly Trp Leu Glu Pro Trp Ser Gly 
                165                 170                 175     


Gln Pro Ala His Pro Pro Leu Asn Leu Ser Ala Lys Thr Glu Leu Val 
            180                 185                 190         


Ala Trp Ala Val Ser Asn Trp Gly Pro Asn Ser Ala Arg Val Arg Tyr 
        195                 200                 205             


Tyr Gln Ser Leu Gln Ala His Leu Lys Val Asp Val Tyr Gly Arg Ser 
    210                 215                 220                 


His Lys Pro Leu Pro Gln Gly Thr Met Met Glu Thr Leu Ser Arg Tyr 
225                 230                 235                 240 


Lys Phe Tyr Leu Ala Phe Glu Asn Ser Leu His Pro Asp Tyr Ile Thr 
                245                 250                 255     


Glu Lys Leu Trp Arg Asn Ala Leu Glu Ala Trp Ala Val Pro Val Val 
            260                 265                 270         


Leu Gly Pro Ser Arg Ser Asn Tyr Glu Arg Phe Leu Pro Pro Asp Ala 
        275                 280                 285             


Phe Ile His Val Asp Asp Phe Gln Ser Pro Lys Asp Leu Ala Arg Tyr 
    290                 295                 300                 


Leu Gln Glu Leu Asp Lys Asp His Ala Arg Tyr Leu Ser Tyr Phe Arg 
305                 310                 315                 320 


Trp Arg Glu Thr Leu Arg Pro Arg Ser Phe Ser Trp Ala Leu Ala Phe 
                325                 330                 335     


Cys Lys Ala Cys Trp Lys Leu Gln Glu Glu Ser Arg Tyr Gln Thr Arg 
            340                 345                 350         


Gly Ile Ala Ala Trp Phe Thr 
        355                 

<210>  3349
<211>  3125
<212>  DNA
<213>  Homo sapiens

<400>  3349
gtcaacctca ccagtcaagg aatgagacat gagtggaatt aggttgccac ttctggagct     60

ctgggagacc ccaaccccct ggcccatccc tacctcccag aacctcactg gtctgggcgt    120

ggctgggcac tgagatagta gaactcaggc agcatgatgc agcctcccag aaatgatttc    180

tagaacaggg cagtcgtgat acttggaggc tgggctttga gctcggtcac ctttgcaccc    240

agcttgggag tgagagagtt taaggtcatc ctccctcaaa accagtattc cagatcattt    300

ctctccattc caggaagttt gcatagctcc ctggacttct gctttgcact gccctgcagg    360

agtgggtggg gaaaggaagt ggctttgagg cacacagagg ggcttgttga ggccaccgga    420

ggaagcttct gccaccaata tgggacctgt gcccagccta ccagaagaga gcatctgaaa    480

acatgtatcg acatggtaac ccctctgctt gaagcctcac atggctccct attgccttgg    540

tgctgaacac cctatggctg accgtggccc agcctctgca acagctctgc ctcctctcca    600

gtggtgaaga cccagcctgc tgagactcct cctgcagttc ctcaacatgc ctgcatttct    660

gctgcctcag ggcctttgcg aaggttgttc cttgtaactg gaatgccctt ccatcccttt    720

tttattcaaa aggctgcaat tttaattgaa gaaagttccc ttccaaggtt catgagttgc    780

ctgacttgcc caccggtttc ctgcaagatc ccttggcctg gcacttagtg ctcaggaaat    840

atttggtgat gggccaactg agtgagaagg tgggatctgg tgggaaggaa agcggaaagg    900

tagaaattct gctcacttcc tcattcccac ctcccaagga acccctggtg tccctgtgga    960

acccgctttg ggaaccggtg gttcaggtca gccttttcac tttgtactca aagccacatc   1020

gcattgaagc cacaggtggg gcaaggtcat gcatgacctg agtctccaaa tcccttcacc   1080

ctgtttggtt ctgcaacggg gattagggga gccccacgat ttgttttcaa aggatgtccg   1140

ggctccagga caggatgccc tgggtcacct gatgacaggt gtggtggttg gaaagggcct   1200

ggtttcagct ccgggtacac ttcctccttc cttctgctgc gtggtgtggc ctcttccacg   1260

tcctcagaat ccagctgtta ctccgtccgc ggcctctcag ctctagggcc ctctgcacac   1320

tggccccccc agatactctg acccatggat cccctgggcc cggccaagcc acagtggtcg   1380

tggcgctgct gtctgaccac gctgctgttt cagctgctga tggctgtgtg tttcttctcc   1440

tatctgcgtg tgtctcaaga cgatcccact gtgtacccta atgggtcccg cttcccagac   1500

agcacaggga cccccgccca ctccatcccc ctgatcctgc tgtggacgtg gccttttaac   1560

aaacccatag ctctgccccg ctgctcagag atggtgcctg gcacggctga ctgcaacatc   1620

actgccgacc gcaaggtgta tccacaggca gacgcggtca tcgtgcacca ccgagaggtc   1680

atgtacaacc ccagtgccca gctcccacgc tccccgaggc ggcaggggca gcgatggatc   1740

tggttcagca tggagtcccc aagccactgc tggcagctga aagccatgga cggatacttc   1800

aatctcacca tgtcctaccg cagcgactcc gacatcttca cgccctacgg ctggctggag   1860

ccgtggtccg gccagcctgc ccacccaccg ctcaacctct cggccaagac cgagctggtg   1920

gcctgggcag tgtccaactg ggggccaaac tccgccaggg tgcgctacta ccagagcctg   1980

caggcccatc tcaaggtgga cgtgtacgga cgctcccaca agcccctgcc ccagggaacc   2040

atgatggaga cgctgtcccg gtacaagttc tatctggcct tcgagaactc cttgcacccc   2100

gactacatca ccgagaagct gtggaggaac gccctggagg cctgggccgt gcccgtggtg   2160

ctgggcccca gcagaagcaa ctacgagagg ttcctgccac ccgacgcctt catccacgtg   2220

gacgacttcc agagccccaa ggacctggcc cggtacctgc aggagctgga caaggaccac   2280

gcccgctacc tgagctactt tcgctggcgg gagacgctgc ggcctcgctc cttcagctgg   2340

gcactcgctt tctgcaaggc ctgctggaaa ctgcaggagg aatccaggta ccagacacgc   2400

ggcatagcgg cttggttcac ctgagaggct ggtgtggggc ctgggctgcc aggaacctca   2460

ttttcctggg gcctcacctg agtgggggcc tcatctacct aaggactcgt ttgcctgaag   2520

cttcacctgc ctgaggactc acctgcctgg gacggtcacc tgttgcagct tcacctgcct   2580

ggggattcac ctacctgggt cctcactttc ctggggcctc acctgctgga gtcttcggtg   2640

gccaggtatg tcccttacct gggatttcac atgctggctt ccaggagcgt cccctgcgga   2700

agcctggcct gctggggatg tctcctgggg actttgccta ctggggacct cggctgttgg   2760

ggactttacc tgctgggacc tgctcccaga gaccttccac actgaatctc acctgctagg   2820

agcctcacct gctggggacc tcaccctgga gggcactggg ccctgggaac tggcacccat   2880

ggggccccac ccatgagtga tggttctggc tgatttgttt gtgatgttgt tagccgcctg   2940

tgaggggtgc agagagataa tcaccgcacc gtttccagat gtaatactgc aaagaaaacc   3000

gatgatgagg ccgggtgcgg tggctcacac ctgtaatccc agcactttgg gaggccgagg   3060

caggcggatc acaaggtcag gagatcgaga ccatcctggc caatatggtg aaacccgtct   3120

ctact                                                               3125


<210>  3350
<211>  359
<212>  PRT
<213>  Homo sapiens

<400>  3350


Met Asp Pro Leu Gly Pro Ala Lys Pro Gln Trp Ser Trp Arg Cys Cys 
1               5                   10                  15      


Leu Thr Thr Leu Leu Phe Gln Leu Leu Met Ala Val Cys Phe Phe Ser 
            20                  25                  30          


Tyr Leu Arg Val Ser Gln Asp Asp Pro Thr Val Tyr Pro Asn Gly Ser 
        35                  40                  45              


Arg Phe Pro Asp Ser Thr Gly Thr Pro Ala His Ser Ile Pro Leu Ile 
    50                  55                  60                  


Leu Leu Trp Thr Trp Pro Phe Asn Lys Pro Ile Ala Leu Pro Arg Cys 
65                  70                  75                  80  


Ser Glu Met Val Pro Gly Thr Ala Asp Cys Asn Ile Thr Ala Asp Arg 
                85                  90                  95      


Lys Val Tyr Pro Gln Ala Asp Ala Val Ile Val His His Arg Glu Val 
            100                 105                 110         


Met Tyr Asn Pro Ser Ala Gln Leu Pro Arg Ser Pro Arg Arg Gln Gly 
        115                 120                 125             


Gln Arg Trp Ile Trp Phe Ser Met Glu Ser Pro Ser His Cys Trp Gln 
    130                 135                 140                 


Leu Lys Ala Met Asp Gly Tyr Phe Asn Leu Thr Met Ser Tyr Arg Ser 
145                 150                 155                 160 


Asp Ser Asp Ile Phe Thr Pro Tyr Gly Trp Leu Glu Pro Trp Ser Gly 
                165                 170                 175     


Gln Pro Ala His Pro Pro Leu Asn Leu Ser Ala Lys Thr Glu Leu Val 
            180                 185                 190         


Ala Trp Ala Val Ser Asn Trp Gly Pro Asn Ser Ala Arg Val Arg Tyr 
        195                 200                 205             


Tyr Gln Ser Leu Gln Ala His Leu Lys Val Asp Val Tyr Gly Arg Ser 
    210                 215                 220                 


His Lys Pro Leu Pro Gln Gly Thr Met Met Glu Thr Leu Ser Arg Tyr 
225                 230                 235                 240 


Lys Phe Tyr Leu Ala Phe Glu Asn Ser Leu His Pro Asp Tyr Ile Thr 
                245                 250                 255     


Glu Lys Leu Trp Arg Asn Ala Leu Glu Ala Trp Ala Val Pro Val Val 
            260                 265                 270         


Leu Gly Pro Ser Arg Ser Asn Tyr Glu Arg Phe Leu Pro Pro Asp Ala 
        275                 280                 285             


Phe Ile His Val Asp Asp Phe Gln Ser Pro Lys Asp Leu Ala Arg Tyr 
    290                 295                 300                 


Leu Gln Glu Leu Asp Lys Asp His Ala Arg Tyr Leu Ser Tyr Phe Arg 
305                 310                 315                 320 


Trp Arg Glu Thr Leu Arg Pro Arg Ser Phe Ser Trp Ala Leu Ala Phe 
                325                 330                 335     


Cys Lys Ala Cys Trp Lys Leu Gln Glu Glu Ser Arg Tyr Gln Thr Arg 
            340                 345                 350         


Gly Ile Ala Ala Trp Phe Thr 
        355                 

<210>  3351
<211>  914
<212>  DNA
<213>  Homo sapiens

<400>  3351
atggatcccc tgggcccggc caagccacag tggtcgtggc gctgctgtct gaccacgctg     60

ctgtttcagc tgctgatggc tgtgtgtttc ttctcctatc tgcgtgtgtc tcaagacgat    120

cccactgtgt accctaatgg gtcccgcttc ccagacagca cagggacccc cgcccactcc    180

atccccctga tcctgctgtg gacgtggcct tttaacaaac ccatagctct gccccgctgc    240

tcagagatgg tgcctggcac ggctgactgc aacatcactg ccgaccgcaa ggtgtatcca    300

caggcagacg cggtcatcgt gcaccaccga gaggtcatgt acaaccccag tgcccagctc    360

ccacgctccc cgaggcggca ggggcagcga tggatctggt tcagcatgga gtccccaagc    420

cactgctggc agctgaaagc catggacgga tacttcaatc tcaccatgtc ctaccgcagc    480

gactccgaca tcttcacgcc ctacggctgg ctggagccgt ggtccggcca gcctgcccac    540

ccaccgctca acctctcggc caagaccgag ctggtggcct gggcagtgtc caactggggg    600

ccaaactccg ccagggtgcg ctactaccag agcctgcagg cccatctcaa ggtggacgtg    660

tacggacgct cccacaagcc cctgccccag ggaaccatga tggagacgct gtcccggtac    720

aagttctatc tggccttcga gaactccttg caccccgact acatcaccga gaagctgtgg    780

aggaacgccc tggaggcctg ggccgtgccc gtggtgctgg gccccagcag aagcaactca    840

ttttcctggg gcctcacctg agtgggggcc tcatctacct aaggactcgt ttgcctgaag    900

cttcacctgc ctga                                                      914


<210>  3352
<211>  286
<212>  PRT
<213>  Homo sapiens

<400>  3352


Met Asp Pro Leu Gly Pro Ala Lys Pro Gln Trp Ser Trp Arg Cys Cys 
1               5                   10                  15      


Leu Thr Thr Leu Leu Phe Gln Leu Leu Met Ala Val Cys Phe Phe Ser 
            20                  25                  30          


Tyr Leu Arg Val Ser Gln Asp Asp Pro Thr Val Tyr Pro Asn Gly Ser 
        35                  40                  45              


Arg Phe Pro Asp Ser Thr Gly Thr Pro Ala His Ser Ile Pro Leu Ile 
    50                  55                  60                  


Leu Leu Trp Thr Trp Pro Phe Asn Lys Pro Ile Ala Leu Pro Arg Cys 
65                  70                  75                  80  


Ser Glu Met Val Pro Gly Thr Ala Asp Cys Asn Ile Thr Ala Asp Arg 
                85                  90                  95      


Lys Val Tyr Pro Gln Ala Asp Ala Val Ile Val His His Arg Glu Val 
            100                 105                 110         


Met Tyr Asn Pro Ser Ala Gln Leu Pro Arg Ser Pro Arg Arg Gln Gly 
        115                 120                 125             


Gln Arg Trp Ile Trp Phe Ser Met Glu Ser Pro Ser His Cys Trp Gln 
    130                 135                 140                 


Leu Lys Ala Met Asp Gly Tyr Phe Asn Leu Thr Met Ser Tyr Arg Ser 
145                 150                 155                 160 


Asp Ser Asp Ile Phe Thr Pro Tyr Gly Trp Leu Glu Pro Trp Ser Gly 
                165                 170                 175     


Gln Pro Ala His Pro Pro Leu Asn Leu Ser Ala Lys Thr Glu Leu Val 
            180                 185                 190         


Ala Trp Ala Val Ser Asn Trp Gly Pro Asn Ser Ala Arg Val Arg Tyr 
        195                 200                 205             


Tyr Gln Ser Leu Gln Ala His Leu Lys Val Asp Val Tyr Gly Arg Ser 
    210                 215                 220                 


His Lys Pro Leu Pro Gln Gly Thr Met Met Glu Thr Leu Ser Arg Tyr 
225                 230                 235                 240 


Lys Phe Tyr Leu Ala Phe Glu Asn Ser Leu His Pro Asp Tyr Ile Thr 
                245                 250                 255     


Glu Lys Leu Trp Arg Asn Ala Leu Glu Ala Trp Ala Val Pro Val Val 
            260                 265                 270         


Leu Gly Pro Ser Arg Ser Asn Ser Phe Ser Trp Gly Leu Thr 
        275                 280                 285     

<210>  3353
<211>  1095
<212>  DNA
<213>  Homo sapiens

<400>  3353
atggatcccc tgggcccggc caagccacag tggtcgtggc gctgctgtct gaccacgctg     60

ctgtttcagc tgctgatggc tgtgtgtttc ttctcctatc tgcgtgtgtc tcaagacgat    120

cccactgtgt accctaatgg gtcccgcttc ccagacagca cagggacccc cgcccactcc    180

atccccctga tcctgctgtg gacgtggcct tttaacaaac ccatagctct gccccgctgc    240

tcagagatgg tgcctggcac ggctgactgc aacatcactg ccgaccgcaa ggtgtatcca    300

caggcagacg cggtcatcgt gcaccaccga gaggtcatgt acaaccccag tgcccagctc    360

ccacgctccc cgaggcggca ggggcagcga tggatctggt tcagcatgga gtccccaagc    420

cactgctggc agctgaaagc catggacgga tacttcaatc tcaccatgtc ctaccgcagc    480

gactccgaca tcttcacgcc ctacggctgg ctggagccgt ggtccggcca gcctgcccac    540

ccaccgctca acctctcggc caagaccgag ctggtggcct gggcagtgtc caactggggg    600

ccaaactccg ccagggtgcg ctactaccag agcctgcagg cccatctcaa ggtggacgtg    660

tacggacgct cccacaagcc cctgccccag ggaaccatga tggagacgct gtcccggtac    720

aagttctatc tggccttcga gaactccttg caccccgact acatcaccga gaagctgtgg    780

aggaacgccc tggaggcctg ggccgtgccc gtggtgctgg gccccagcag aagcaactac    840

gagaggttcc tgccacccga cgccttcatc cacgtggacg acttccagag ccccaaggac    900

ctggcccggt acctgcagga gctggacaag gaccacgccc gctacctgag ctactttcgc    960

tggcgggaga cgctgcggcc tcgctccttc agctgggcac tcgctttctg caaggcctgc   1020

tggaaactgc aggaggaatc cagtgggggc ctcatctacc taaggactcg tttgcctgaa   1080

gcttcacctg cctga                                                    1095


<210>  3354
<211>  364
<212>  PRT
<213>  Homo sapiens

<400>  3354


Met Asp Pro Leu Gly Pro Ala Lys Pro Gln Trp Ser Trp Arg Cys Cys 
1               5                   10                  15      


Leu Thr Thr Leu Leu Phe Gln Leu Leu Met Ala Val Cys Phe Phe Ser 
            20                  25                  30          


Tyr Leu Arg Val Ser Gln Asp Asp Pro Thr Val Tyr Pro Asn Gly Ser 
        35                  40                  45              


Arg Phe Pro Asp Ser Thr Gly Thr Pro Ala His Ser Ile Pro Leu Ile 
    50                  55                  60                  


Leu Leu Trp Thr Trp Pro Phe Asn Lys Pro Ile Ala Leu Pro Arg Cys 
65                  70                  75                  80  


Ser Glu Met Val Pro Gly Thr Ala Asp Cys Asn Ile Thr Ala Asp Arg 
                85                  90                  95      


Lys Val Tyr Pro Gln Ala Asp Ala Val Ile Val His His Arg Glu Val 
            100                 105                 110         


Met Tyr Asn Pro Ser Ala Gln Leu Pro Arg Ser Pro Arg Arg Gln Gly 
        115                 120                 125             


Gln Arg Trp Ile Trp Phe Ser Met Glu Ser Pro Ser His Cys Trp Gln 
    130                 135                 140                 


Leu Lys Ala Met Asp Gly Tyr Phe Asn Leu Thr Met Ser Tyr Arg Ser 
145                 150                 155                 160 


Asp Ser Asp Ile Phe Thr Pro Tyr Gly Trp Leu Glu Pro Trp Ser Gly 
                165                 170                 175     


Gln Pro Ala His Pro Pro Leu Asn Leu Ser Ala Lys Thr Glu Leu Val 
            180                 185                 190         


Ala Trp Ala Val Ser Asn Trp Gly Pro Asn Ser Ala Arg Val Arg Tyr 
        195                 200                 205             


Tyr Gln Ser Leu Gln Ala His Leu Lys Val Asp Val Tyr Gly Arg Ser 
    210                 215                 220                 


His Lys Pro Leu Pro Gln Gly Thr Met Met Glu Thr Leu Ser Arg Tyr 
225                 230                 235                 240 


Lys Phe Tyr Leu Ala Phe Glu Asn Ser Leu His Pro Asp Tyr Ile Thr 
                245                 250                 255     


Glu Lys Leu Trp Arg Asn Ala Leu Glu Ala Trp Ala Val Pro Val Val 
            260                 265                 270         


Leu Gly Pro Ser Arg Ser Asn Tyr Glu Arg Phe Leu Pro Pro Asp Ala 
        275                 280                 285             


Phe Ile His Val Asp Asp Phe Gln Ser Pro Lys Asp Leu Ala Arg Tyr 
    290                 295                 300                 


Leu Gln Glu Leu Asp Lys Asp His Ala Arg Tyr Leu Ser Tyr Phe Arg 
305                 310                 315                 320 


Trp Arg Glu Thr Leu Arg Pro Arg Ser Phe Ser Trp Ala Leu Ala Phe 
                325                 330                 335     


Cys Lys Ala Cys Trp Lys Leu Gln Glu Glu Ser Ser Gly Gly Leu Ile 
            340                 345                 350         


Tyr Leu Arg Thr Arg Leu Pro Glu Ala Ser Pro Ala 
        355                 360                 

<210>  3355
<211>  1356
<212>  DNA
<213>  Homo sapiens

<400>  3355
tccgtccgcg gcctctcagc tctagggccc tctgcacact ggccccccca gtgtcacggg     60

catccagacg ggatccagtg catcctcttt tagaagaaag gcctgtctcc agatccccga    120

gtccctctag catctcccag aaggtgtcag acgcagcagt gtccagggag cggcagcagg    180

tccttatcat ggtccaaggg tccctcccag cctccaagtc tcaccccata catgaaaaaa    240

ggtggccccg gtttcccgcc acctcctcca cagcaccatc tctttgaaga cccagtgccc    300

acactccggg ggatttgggc cctcccctgt ctccctccag ccccctgggg ccagtccgct    360

gctgggtatc tccaggacgg gccaggctca gcaagttcca ccaaagcctg cttctctcct    420

gggggttccc catgtctctg ggtggcccca ctgccctcct ggtcagcata ttgaggaaga    480

gtctggggac acaccagaaa aggacaggat caagatactc tgacccatgg atcccctggg    540

cccggccaag ccacagtggt cgtggcgctg ctgtctgacc acgctgctgt ttcagctgct    600

gatggctgtg tgtttcttct cctatctgcg tgtgtctcaa gacgatccca ctgtgtaccc    660

taatgggtcc cgcttcccag acagcacagg gacccccgcc cactccatcc ccctgatcct    720

gctgtggacg tggcctttta acaaacccat agctctgccc cgctgctcag agatggtgcc    780

tggcacggct gactgcaaca tcactgccga ccgcaaggtg tatccacagg cagacgcggt    840

catcgtgcac caccgagagg tcatgtacaa ccccagtgcc cagctcccac gctccccgag    900

gcggcagggg cagcgatgga tctggttcag catggagtcc ccaagccact gctggcagct    960

gaaagccatg gacggatact tcaatctcac catgtcctac cgcagcgact ccgacatctt   1020

cacgccctac ggctggctgg agccgtggtc cggccagcct gcccacccac cgctcaacct   1080

ctcggccaag accgagctgg tggcctgggc agtgtccaac tgggggccaa actccgccag   1140

ggtgcgctac taccagagcc tgcaggccca tctcaaggtg gacgtgtacg gacgctccca   1200

caagcccctg ccccagggaa ccatgatgga gacgctgtcc cggtacaagt tctatctggc   1260

cttcgagaac tccttgcacc ccgactacat caccgagaag ctgtggagga acgccctgga   1320

ggcctgggcc gtgcccgtgg tgctgggccc cagcag                             1356


<210>  3356
<211>  80
<212>  PRT
<213>  Homo sapiens

<400>  3356


Met Lys Lys Gly Gly Pro Gly Phe Pro Pro Pro Pro Pro Gln His His 
1               5                   10                  15      


Leu Phe Glu Asp Pro Val Pro Thr Leu Arg Gly Ile Trp Ala Leu Pro 
            20                  25                  30          


Cys Leu Pro Pro Ala Pro Trp Gly Gln Ser Ala Ala Gly Tyr Leu Gln 
        35                  40                  45              


Asp Gly Pro Gly Ser Ala Ser Ser Thr Lys Ala Cys Phe Ser Pro Gly 
    50                  55                  60                  


Gly Ser Pro Cys Leu Trp Val Ala Pro Leu Pro Ser Trp Ser Ala Tyr 
65                  70                  75                  80  

<210>  3357
<211>  1266
<212>  DNA
<213>  Homo sapiens

<400>  3357
ctcagaatcc agctgttact ccgtccgcgg cctctcagct ctagggccct ctgcacactg     60

gcccccccag tgggtgtctg tctgtctctc ttgcagagct ctgcggtaga atcccgtgcc    120

ccccgacccc atcagcagcc tacacccctt catccttcct ggccccggat tttctctgcc    180

tctgccactc ccggtggtaa aagagggctt agaatgcggt ttgctttctg gctttgtttt    240

tttgcatcct gatctttgtg gcgtggatcg atcattttcc agggaaagta ccttggtgtc    300

acgggcatcc agacgggatc cagtgcatcc tcttttagaa gaaaggcctg tctccagatc    360

cccgagtccc tctagcatct cccagaaggt gtcagacgca gcagtgtcca gggagcggca    420

gcagatactc tgacccatgg atcccctggg cccggccaag ccacagtggt cgtggcgctg    480

ctgtctgacc acgctgctgt ttcagctgct gatggctgtg tgtttcttct cctatctgcg    540

tgtgtctcaa gacgatccca ctgtgtaccc taatgggtcc cgcttcccag acagcacagg    600

gacccccgcc cactccatcc ccctgatcct gctgtggacg tggcctttta acaaacccat    660

agctctgccc cgctgctcag agatggtgcc tggcacggct gactgcaaca tcactgccga    720

ccgcaaggtg tatccacagg cagacgcggt catcgtgcac caccgagagg tcatgtacaa    780

ccccagtgcc cagctcccac gctccccgag gcggcagggg cagcgatgga tctggttcag    840

catggagtcc ccaagccact gctggcagct gaaagccatg gacggatact tcaatctcac    900

catgtcctac cgcagcgact ccgacatctt cacgccctac ggctggctgg agccgtggtc    960

cggccagcct gcccacccac cgctcaacct ctcggccaag accgagctgg tggcctgggc   1020

agtgtccaac tgggggccaa actccgccag ggtgcgctac taccagagcc tgcaggccca   1080

tctcaaggtg gacgtgtacg gacgctccca caagcccctg ccccagggaa ccatgatgga   1140

gacgctgtcc cggtacaagt tctatctggc cttcgagaac tccttgcacc ccgactacat   1200

caccgagaag ctgtggagga acgccctgga ggcctgggcc gtgcccgtgg tgctgggccc   1260

cagcag                                                              1266


<210>  3358
<211>  275
<212>  PRT
<213>  Homo sapiens

<400>  3358


Met Asp Pro Leu Gly Pro Ala Lys Pro Gln Trp Ser Trp Arg Cys Cys 
1               5                   10                  15      


Leu Thr Thr Leu Leu Phe Gln Leu Leu Met Ala Val Cys Phe Phe Ser 
            20                  25                  30          


Tyr Leu Arg Val Ser Gln Asp Asp Pro Thr Val Tyr Pro Asn Gly Ser 
        35                  40                  45              


Arg Phe Pro Asp Ser Thr Gly Thr Pro Ala His Ser Ile Pro Leu Ile 
    50                  55                  60                  


Leu Leu Trp Thr Trp Pro Phe Asn Lys Pro Ile Ala Leu Pro Arg Cys 
65                  70                  75                  80  


Ser Glu Met Val Pro Gly Thr Ala Asp Cys Asn Ile Thr Ala Asp Arg 
                85                  90                  95      


Lys Val Tyr Pro Gln Ala Asp Ala Val Ile Val His His Arg Glu Val 
            100                 105                 110         


Met Tyr Asn Pro Ser Ala Gln Leu Pro Arg Ser Pro Arg Arg Gln Gly 
        115                 120                 125             


Gln Arg Trp Ile Trp Phe Ser Met Glu Ser Pro Ser His Cys Trp Gln 
    130                 135                 140                 


Leu Lys Ala Met Asp Gly Tyr Phe Asn Leu Thr Met Ser Tyr Arg Ser 
145                 150                 155                 160 


Asp Ser Asp Ile Phe Thr Pro Tyr Gly Trp Leu Glu Pro Trp Ser Gly 
                165                 170                 175     


Gln Pro Ala His Pro Pro Leu Asn Leu Ser Ala Lys Thr Glu Leu Val 
            180                 185                 190         


Ala Trp Ala Val Ser Asn Trp Gly Pro Asn Ser Ala Arg Val Arg Tyr 
        195                 200                 205             


Tyr Gln Ser Leu Gln Ala His Leu Lys Val Asp Val Tyr Gly Arg Ser 
    210                 215                 220                 


His Lys Pro Leu Pro Gln Gly Thr Met Met Glu Thr Leu Ser Arg Tyr 
225                 230                 235                 240 


Lys Phe Tyr Leu Ala Phe Glu Asn Ser Leu His Pro Asp Tyr Ile Thr 
                245                 250                 255     


Glu Lys Leu Trp Arg Asn Ala Leu Glu Ala Trp Ala Val Pro Val Val 
            260                 265                 270         


Leu Gly Pro 
        275 

<210>  3359
<211>  1194
<212>  DNA
<213>  Homo sapiens

<400>  3359
acttcctcct tccttctgct gcgtggtgtg gcctcttcca cgtcctcaga atccagctgt     60

tactccgtcc gcggcctctc agctctaggg ccctctgcac actggccccc ccagtgtcac    120

gggcatccag acgggatcca gtgcatcctc ttttagaaga aaggcctgtc tccagatccc    180

cgagtccctc tagcatctcc cagaaggtgt cagacgcagc agtgtccagg gagcggcagc    240

aggtccttat catggtccaa gggtccctcc cagcctccaa gtctcacccc atacatgaaa    300

aaaggtggcc ccggtttccc gccacctcct ccacagcacc atctctttga agatactctg    360

acccatggat cccctgggcc cggccaagcc acagtggtcg tggcgctgct gtctgaccac    420

gctgctgttt cagctgctga tggctgtgtg tttcttctcc tatctgcgtg tgtctcaaga    480

cgatcccact gtgtacccta atgggtcccg cttcccagac agcacaggga cccccgccca    540

ctccatcccc ctgatcctgc tgtggacgtg gccttttaac aaacccatag ctctgccccg    600

ctgctcagag atggtgcctg gcacggctga ctgcaacatc actgccgacc gcaaggtgta    660

tccacaggca gacgcggtca tcgtgcacca ccgagaggtc atgtacaacc ccagtgccca    720

gctcccacgc tccccgaggc ggcaggggca gcgatggatc tggttcagca tggagtcccc    780

aagccactgc tggcagctga aagccatgga cggatacttc aatctcacca tgtcctaccg    840

cagcgactcc gacatcttca cgccctacgg ctggctggag ccgtggtccg gccagcctgc    900

ccacccaccg ctcaacctct cggccaagac cgagctggtg gcctgggcag tgtccaactg    960

ggggccaaac tccgccaggg tgcgctacta ccagagcctg caggcccatc tcaaggtgga   1020

cgtgtacgga cgctcccaca agcccctgcc ccagggaacc atgatggaga cgctgtcccg   1080

gtacaagttc tatctggcct tcgagaactc cttgcacccc gactacatca ccgagaagct   1140

gtggaggaac gccctggagg cctgggccgt gcccgtggtg ctgggcccca gcag         1194


<210>  3360
<211>  68
<212>  PRT
<213>  Homo sapiens

<400>  3360


Met Lys Lys Gly Gly Pro Gly Phe Pro Pro Pro Pro Pro Gln His His 
1               5                   10                  15      


Leu Phe Glu Asp Thr Leu Thr His Gly Ser Pro Gly Pro Gly Gln Ala 
            20                  25                  30          


Thr Val Val Val Ala Leu Leu Ser Asp His Ala Ala Val Ser Ala Ala 
        35                  40                  45              


Asp Gly Cys Val Phe Leu Leu Leu Ser Ala Cys Val Ser Arg Arg Ser 
    50                  55                  60                  


His Cys Val Pro 
65              

<210>  3361
<211>  715
<212>  DNA
<213>  Homo sapiens

<400>  3361
attccagatc atttctctcc attccaggaa gtttgcatag ctccctggac ttctgctttg     60

catccatccc cctgatcctg ctgtggacgt ggccttttaa caaacccata gctctgcccc    120

gctgctcaga gatggtgcct ggcacggctg actgcaacat cactgccgac cgcaaggtgt    180

atccacaggc agacgcggtc atcgtgcacc accgagaggt catgtacaac cccagtgccc    240

agctcccacg ctccccgagg cggcaggggc agcgatggat ctggttcagc atggagtccc    300

caagccactg ctggcagctg aaagccatgg acggatactt caatctcacc atgtcctacc    360

gcagcgactc cgacatcttc acgccctacg gctggctgga gccgtggtcc ggccagcctg    420

cccacccacc gctcaacctc tcggccaaga ccgagctggt ggcctgggca gtgtccaact    480

gggggccaaa ctccgccagg gtgcgctact accagagcct gcaggcccat ctcaaggtgg    540

acgtgtacgg acgctcccac aagcccctgc cccagggaac catgatggag acgctgtccc    600

ggtacaagtt ctatctggcc ttcgagaact ccttgcaccc cgactacatc accgagaagc    660

tgtggaggaa cgccctggag gcctgggccg tgcccgtggt gctgggcccc agcag         715


<210>  3362
<211>  193
<212>  PRT
<213>  Homo sapiens

<400>  3362


Met Val Pro Gly Thr Ala Asp Cys Asn Ile Thr Ala Asp Arg Lys Val 
1               5                   10                  15      


Tyr Pro Gln Ala Asp Ala Val Ile Val His His Arg Glu Val Met Tyr 
            20                  25                  30          


Asn Pro Ser Ala Gln Leu Pro Arg Ser Pro Arg Arg Gln Gly Gln Arg 
        35                  40                  45              


Trp Ile Trp Phe Ser Met Glu Ser Pro Ser His Cys Trp Gln Leu Lys 
    50                  55                  60                  


Ala Met Asp Gly Tyr Phe Asn Leu Thr Met Ser Tyr Arg Ser Asp Ser 
65                  70                  75                  80  


Asp Ile Phe Thr Pro Tyr Gly Trp Leu Glu Pro Trp Ser Gly Gln Pro 
                85                  90                  95      


Ala His Pro Pro Leu Asn Leu Ser Ala Lys Thr Glu Leu Val Ala Trp 
            100                 105                 110         


Ala Val Ser Asn Trp Gly Pro Asn Ser Ala Arg Val Arg Tyr Tyr Gln 
        115                 120                 125             


Ser Leu Gln Ala His Leu Lys Val Asp Val Tyr Gly Arg Ser His Lys 
    130                 135                 140                 


Pro Leu Pro Gln Gly Thr Met Met Glu Thr Leu Ser Arg Tyr Lys Phe 
145                 150                 155                 160 


Tyr Leu Ala Phe Glu Asn Ser Leu His Pro Asp Tyr Ile Thr Glu Lys 
                165                 170                 175     


Leu Trp Arg Asn Ala Leu Glu Ala Trp Ala Val Pro Val Val Leu Gly 
            180                 185                 190         


Pro 
    

<210>  3363
<211>  2988
<212>  DNA
<213>  Homo sapiens

<400>  3363
gtcaacctca ccagtcaagg aatgagacat gagtggaatt aggttgccac ttctggagct     60

ctgggagacc ccaaccccct ggcccatccc tacctcccag aacctcactg gtctgggcgt    120

ggctgggcac tgagatagta gaactcaggc agcatgatgc agcctcccag aaatgatttc    180

tagaacaggg cagtcgtgat acttggaggc tgggctttga gctcggtcac ctttgcaccc    240

agcttgggag tgagagagtt taaggtcatc ctccctcaaa accagtattc cagatcattt    300

ctctccattc caggaagttt gcatagctcc ctggacttct gctttgcact gccctgcagg    360

agtgggtggg gaaaggaagt ggctttgagg cacacagagg ggcttgttga ggccaccgga    420

ggaagcttct gccaccaata tgggacctgt gcccagccta ccagaagaga gcatctgaaa    480

acatgtatcg acatggtaac ccctctgctt gaagcctcac atggctccct attgccttgg    540

tgctgaacac cctatggctg accgtggccc agcctctgca acagctctgc ctcctctcca    600

gtggtgaaga cccagcctgc tgagactcct cctgcagttc ctcaacatgc ctgcatttct    660

gctgcctcag ggcctttgcg aaggttgttc cttgtaactg gaatgccctt ccatcccttt    720

tttattcaaa aggctgcaat tttaattgaa gaaagttccc ttccaaggtt catgagttgc    780

ctgacttgcc caccggtttc ctgcaagatc ccttggcctg gcacttagtg ctcaggaaat    840

atttggtgat gggccaactg agtgagaagg tgggatctgg tgggaaggaa agcggaaagg    900

tagaaattct gctcacttcc tcattcccac ctcccaagga acccctggtg tccctgtgga    960

acccgctttg ggaaccggtg gttcaggtca gccttttcac tttgtactca aagccacatc   1020

gcattgaagc cacaggtggg gcaaggtcat gcatgacctg agtctccaaa tcccttcacc   1080

ctgtttggtt ctgcaacggg gattagggga gccccacgat ttgttttcaa aggatgtccg   1140

ggctccagga caggatgccc tgggtcacct gatgacaggt gtggtggttg gaaagggcct   1200

ggtttcagct ccgggtacac ttcctccttc cttctgctgc gtggtgtggc ctcttccacg   1260

tcctcagaat ccagctgtta ctccgtccgc ggcctctcag ctctagggcc ctctgcacac   1320

tggccccccc aggtaaggcc tcttgtccca ctttcacccc caacccggat cgcatgggtc   1380

cagggaaagg cctcctggct ccgagcctcc tcccctcagc ctcagtcctg tctgctgtaa   1440

ttcagagtgc gggtgggctg gcacaagatc cctgggggag ggtctgcagg ctgtgcagtg   1500

gcctggcatt tggccagcag cccctagtcg caggcagggg tctttctgga tgcaccgagg   1560

tgggctgagg atatgggagg tctggctgat ttgccaaacc aggaggaagt gggtgtctgt   1620

ctgtctctct tgcagagctc tgcggtagaa tcccgtgccc cccgacccca tcagcagcct   1680

acaccccttc atccttcctg gccccggatt ttctctgcct ctgccactcc cggtggtaaa   1740

agagggctta gaatgcggtt tgctttctgg ctttgttttt ttgcatcctg atctttgtgg   1800

cgtggatcga tcattttcca gggaaagtac cttgggtgag atctctctcc tggactcccg   1860

ttccccgttt cccccaatct cccctcctga aggtcaccgg caaagacttc actgtctcct   1920

aggaagaggt cgccataaac ccaggggcca catgataata tattaatatt aaatgtatct   1980

ctaaacatta acctttcact ggcagcccaa gagcccgaca gcacaaagga atacttggtt   2040

aaaattcaac ctccctccca gtccgggctc tgagtgtccc tcgagggctg tctcttgagt   2100

ctttttccag aactttggta tgcgcttgtg cttccagcct gggtgacaga gcaagattcc   2160

atctcagaac aaacaaacaa acataaaaag tacaggtgaa gaagtagatt tgcccatcca   2220

agatgttctg aaggtactca aaagtttccc aattactgcc tgtaatacca gtcattgctt   2280

tttttctttt tgagtatctg tttcttgtgt gcttttttgt ggtttttgtt ttctgtgttt   2340

ttattttttg ttgttattta tttatttatt tattttgaga cacggtctca ttctattgtc   2400

taagcagaag tgcaatagtg caaccatggc ttacagcagc cttgaacttc tgggctccag   2460

aaatcctcct gcctcagcat cctgagtagc tgagactaca ggccaccatg tctggcaaaa   2520

taataataat aaataataaa attcgttgta gagatgaggt cttgaggtct tgctatgctg   2580

ctcaggctgg tctcaaactc ttggaatcaa gcgatcctcc cacctcagcc gcccaaagca   2640

ttgggattat aggtgtaagc cattactccc ggccagtatc tatttttaag tttaaattag   2700

cattgggccg ggcgccgtgg tgcacgcctg taatcctagc actttgggag gccgaggcag   2760

gcagatcacc tgaggtcagg agttcaagac cagcctggac aacatggtga aaccccatct   2820

ctactaaaaa tacaaaaatt agccaggcat gatggcacgt gcctctaatc ccagctactc   2880

aggaggctga ggcaagagaa tcgcttgaac ccgggaggcg gaggttgcag tgagctgaga   2940

tcgtgccatt gcactccagc ctgggcaaca aaagtgaaac tccgtctc                2988


<210>  3364
<211>  100
<212>  PRT
<213>  Homo sapiens

<400>  3364


Met Ser Gly Lys Ile Ile Ile Ile Asn Asn Lys Ile Arg Cys Arg Asp 
1               5                   10                  15      


Glu Val Leu Arg Ser Cys Tyr Ala Ala Gln Ala Gly Leu Lys Leu Leu 
            20                  25                  30          


Glu Ser Ser Asp Pro Pro Thr Ser Ala Ala Gln Ser Ile Gly Ile Ile 
        35                  40                  45              


Gly Val Ser His Tyr Ser Arg Pro Val Ser Ile Phe Lys Phe Lys Leu 
    50                  55                  60                  


Ala Leu Gly Arg Ala Pro Trp Cys Thr Pro Val Ile Leu Ala Leu Trp 
65                  70                  75                  80  


Glu Ala Glu Ala Gly Arg Ser Pro Glu Val Arg Ser Ser Arg Pro Ala 
                85                  90                  95      


Trp Thr Thr Trp 
            100 

<210>  3365
<211>  2575
<212>  DNA
<213>  Homo sapiens

<400>  3365
gggtggggca gaaacagatc acaatggtgg aatgtcatca gctaaggcta ttttcacttc     60

ttttgtagat cttcagttgc ttcaggccat ttgaacgtat atgagccggt cgtaggggat    120

atgatggctt agcttgggct cagaggcctg aaaatcgccc ccaccaatca cctgtttccc    180

ccaatctacc ctcctgaagg tcactgacaa agacttcatt gtctcctagg agaggctgcc    240

atatatccag ggctgacgta attccatctt aatatcagtt acattataaa aatttacctc    300

gtgcctgagg ccccagagcc caagggtgca aagcagtaat tggtcaaagt tcaacttccc    360

tcccactctg ggctcaggct gtcccctgag ggcctgtgtt ttgagtctct ttccagaacc    420

ttggtgtgaa cttaggtctt ggcgtcggga tcccttttcg tcacactcag gtgacctaca    480

gggagctccg ctcgacactg caaggcttag accagttcgg tccaacagag aaagcaggca    540

accaccatgt catttgaaaa cagtttcatc gggatataat tcgcaaccca tacagtgaat    600

ccatttaaga tactctgacc catggatccc ctgggtgcag ccaagccaca atggccatgg    660

cgccgctgtc tggccgcact gctatttcag ctgctggtgg ctgtgtgttt cttctcctac    720

ctgcgtgtgt cccgagacga tgccactgga tcccctaggg ctcccagtgg gtcctcccga    780

caggacacca ctcccacccg ccccaccctc ctgatcctgc tacggacatg gcctttccac    840

atccctgtgg ctctgtcccg ctgttcagag atggtgcccg gcacagccga ctgccacatc    900

actgccgacc gcaaggtgta cccacaggca gacatggtca tcgtgcacca ctgggatatc    960

atgtccaacc ctaagtcacg cctcccacct tccccgaggc cgcaggggca gcgctggatc   1020

tggttcaact tggagccacc ccctaactgc cagcacctgg aagccctgga cagatacttc   1080

aatctcacca tgtcctaccg cagcgactcc gacatcttca cgccctacgg ctggctggag   1140

ccgtggtccg gccagcctgc ccacccaccg ctcaacctct cggccaagac cgagctggtg   1200

gcctgggcgg tgtccaactg gaagccggac tcagccaggg tgcgctacta ccagagcctg   1260

caggctcatc tcaaggtgga cgtgtacgga cgctcccaca agcccctgcc caaggggacc   1320

atgatggaga cgctgtcccg gtacaagttc tacctggcct tcgagaactc cttgcacccc   1380

gactacatca ccgagaagct gtggaggaac gccctggagg cctgggccgt gcccgtggtg   1440

ctgggcccca gcagaagcaa ctacgagagg ttcctgccac ccgacgcctt catccacgtg   1500

gacgacttcc agagccccaa ggacctggcc cggtacctgc aggagctgga caaggaccac   1560

gcccgctacc tgagctactt tcgctggcgg gagacgctgc ggcctcgctc cttcagctgg   1620

gcactggatt tctgcaaggc ctgctggaaa ctgcagcagg aatccaggta ccagacggtg   1680

cgcagcatag cggcttggtt cacctgagag gccggcatgg tgcctgggct gccgggaacc   1740

tcatctgcct ggggcctcac ctgctggagt cctttgtggc caaccctctc tcttacctgg   1800

gacctcacac gctgggcttc acggctgcca ggagcctctc ccctccagaa gacttgcctg   1860

ctagggacct cgcctgctgg ggacctcgcc tgttggggac ctcacctgct ggggacctca   1920

cctgctgggg accttggctg ctggaggctg cacctactga ggatgtcggc ggtcggggac   1980

tttacctgct gggacctgct cccagagacc ttgccacact gaatctcacc tgctggggac   2040

ctcaccctgg agggccctgg gccctgggga actggcttac ttggggcccc acccgggagt   2100

gatggttctg gctgatttgt ttgtgatgtt gttagccgcc tgtgaggggt gcagagagat   2160

catcacggca cggtttccag atgtaatact gcaaggaaaa atgatgacgt gtctcctcac   2220

tctagagggg ttggtcccat gggttaagag ctcaccccag gttctcacct caggggttaa   2280

gagctcagag ttcagacagg tccaagttca agcccaggac caccacttat agggtacagg   2340

tgggatcgac tgtaaatgag gacttctgga acattccaaa tattctgggg ttgagggaaa   2400

ttgctgctgt ctacaaaatg ccaagggtgg acaggcgctg tggctcacgc ctgtaatccc   2460

agcactttgg gaggctgagg taggaggatt gattgaggcc aagagttaaa gaccagcctg   2520

gtcaatatag caagaccacg tctctaaata aaaaataata ggccggccag gcacg        2575


<210>  3366
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  3366


Met Asp Pro Leu Gly Ala Ala Lys Pro Gln Trp Pro Trp Arg Arg Cys 
1               5                   10                  15      


Leu Ala Ala Leu Leu Phe Gln Leu Leu Val Ala Val Cys Phe Phe Ser 
            20                  25                  30          


Tyr Leu Arg Val Ser Arg Asp Asp Ala Thr Gly Ser Pro Arg Ala Pro 
        35                  40                  45              


Ser Gly Ser Ser Arg Gln Asp Thr Thr Pro Thr Arg Pro Thr Leu Leu 
    50                  55                  60                  


Ile Leu Leu Arg Thr Trp Pro Phe His Ile Pro Val Ala Leu Ser Arg 
65                  70                  75                  80  


Cys Ser Glu Met Val Pro Gly Thr Ala Asp Cys His Ile Thr Ala Asp 
                85                  90                  95      


Arg Lys Val Tyr Pro Gln Ala Asp Met Val Ile Val His His Trp Asp 
            100                 105                 110         


Ile Met Ser Asn Pro Lys Ser Arg Leu Pro Pro Ser Pro Arg Pro Gln 
        115                 120                 125             


Gly Gln Arg Trp Ile Trp Phe Asn Leu Glu Pro Pro Pro Asn Cys Gln 
    130                 135                 140                 


His Leu Glu Ala Leu Asp Arg Tyr Phe Asn Leu Thr Met Ser Tyr Arg 
145                 150                 155                 160 


Ser Asp Ser Asp Ile Phe Thr Pro Tyr Gly Trp Leu Glu Pro Trp Ser 
                165                 170                 175     


Gly Gln Pro Ala His Pro Pro Leu Asn Leu Ser Ala Lys Thr Glu Leu 
            180                 185                 190         


Val Ala Trp Ala Val Ser Asn Trp Lys Pro Asp Ser Ala Arg Val Arg 
        195                 200                 205             


Tyr Tyr Gln Ser Leu Gln Ala His Leu Lys Val Asp Val Tyr Gly Arg 
    210                 215                 220                 


Ser His Lys Pro Leu Pro Lys Gly Thr Met Met Glu Thr Leu Ser Arg 
225                 230                 235                 240 


Tyr Lys Phe Tyr Leu Ala Phe Glu Asn Ser Leu His Pro Asp Tyr Ile 
                245                 250                 255     


Thr Glu Lys Leu Trp Arg Asn Ala Leu Glu Ala Trp Ala Val Pro Val 
            260                 265                 270         


Val Leu Gly Pro Ser Arg Ser Asn Tyr Glu Arg Phe Leu Pro Pro Asp 
        275                 280                 285             


Ala Phe Ile His Val Asp Asp Phe Gln Ser Pro Lys Asp Leu Ala Arg 
    290                 295                 300                 


Tyr Leu Gln Glu Leu Asp Lys Asp His Ala Arg Tyr Leu Ser Tyr Phe 
305                 310                 315                 320 


Arg Trp Arg Glu Thr Leu Arg Pro Arg Ser Phe Ser Trp Ala Leu Asp 
                325                 330                 335     


Phe Cys Lys Ala Cys Trp Lys Leu Gln Gln Glu Ser Arg Tyr Gln Thr 
            340                 345                 350         


Val Arg Ser Ile Ala Ala Trp Phe Thr 
        355                 360     

<210>  3367
<211>  2235
<212>  DNA
<213>  Homo sapiens

<400>  3367
gtgcctttag ctccagccac ctctttaaga ggaaactgtt gggcagatgg aggagggcta     60

gtcacggaaa gaaactaacc ttggtgtgaa cttaggtctt ggcgtcggga tcccttttcg    120

tcacactcag gtgacctaca gggagctccg ctcgacactg caaggcttag accagttcgg    180

tccaacagag aaagcaggca accaccatgt catttgaaaa cagtttcatc gggatataat    240

tcgcaaccca tacagtgaat ccatttaaga tactctgacc catggatccc ctgggtgcag    300

ccaagccaca atggccatgg cgccgctgtc tggccgcact gctatttcag ctgctggtgg    360

ctgtgtgttt cttctcctac ctgcgtgtgt cccgagacga tgccactgga tcccctaggg    420

ctcccagtgg gtcctcccga caggacacca ctcccacccg ccccaccctc ctgatcctgc    480

tacggacatg gcctttccac atccctgtgg ctctgtcccg ctgttcagag atggtgcccg    540

gcacagccga ctgccacatc actgccgacc gcaaggtgta cccacaggca gacatggtca    600

tcgtgcacca ctgggatatc atgtccaacc ctaagtcacg cctcccacct tccccgaggc    660

cgcaggggca gcgctggatc tggttcaact tggagccacc ccctaactgc cagcacctgg    720

aagccctgga cagatacttc aatctcacca tgtcctaccg cagcgactcc gacatcttca    780

cgccctacgg ctggctggag ccgtggtccg gccagcctgc ccacccaccg ctcaacctct    840

cggccaagac cgagctggtg gcctgggcgg tgtccaactg gaagccggac tcagccaggg    900

tgcgctacta ccagagcctg caggctcatc tcaaggtgga cgtgtacgga cgctcccaca    960

agcccctgcc caaggggacc atgatggaga cgctgtcccg gtacaagttc tacctggcct   1020

tcgagaactc cttgcacccc gactacatca ccgagaagct gtggaggaac gccctggagg   1080

cctgggccgt gcccgtggtg ctgggcccca gcagaagcaa ctacgagagg ttcctgccac   1140

ccgacgcctt catccacgtg gacgacttcc agagccccaa ggacctggcc cggtacctgc   1200

aggagctgga caaggaccac gcccgctacc tgagctactt tcgctggcgg gagacgctgc   1260

ggcctcgctc cttcagctgg gcactggatt tctgcaaggc ctgctggaaa ctgcagcagg   1320

aatccaggta ccagacggtg cgcagcatag cggcttggtt cacctgagag gccggcatgg   1380

tgcctgggct gccgggaacc tcatctgcct ggggcctcac ctgctggagt cctttgtggc   1440

caaccctctc tcttacctgg gacctcacac gctgggcttc acggctgcca ggagcctctc   1500

ccctccagaa gacttgcctg ctagggacct cgcctgctgg ggacctcgcc tgttggggac   1560

ctcacctgct ggggacctca cctgctgggg accttggctg ctggaggctg cacctactga   1620

ggatgtcggc ggtcggggac tttacctgct gggacctgct cccagagacc ttgccacact   1680

gaatctcacc tgctggggac ctcaccctgg agggccctgg gccctgggga actggcttac   1740

ttggggcccc acccgggagt gatggttctg gctgatttgt ttgtgatgtt gttagccgcc   1800

tgtgaggggt gcagagagat catcacggca cggtttccag atgtaatact gcaaggaaaa   1860

atgatgacgt gtctcctcac tctagagggg ttggtcccat gggttaagag ctcaccccag   1920

gttctcacct caggggttaa gagctcagag ttcagacagg tccaagttca agcccaggac   1980

caccacttat agggtacagg tgggatcgac tgtaaatgag gacttctgga acattccaaa   2040

tattctgggg ttgagggaaa ttgctgctgt ctacaaaatg ccaagggtgg acaggcgctg   2100

tggctcacgc ctgtaatccc agcactttgg gaggctgagg taggaggatt gattgaggcc   2160

aagagttaaa gaccagcctg gtcaatatag caagaccacg tctctaaata aaaaataata   2220

ggccggccag gcacg                                                    2235


<210>  3368
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  3368


Met Asp Pro Leu Gly Ala Ala Lys Pro Gln Trp Pro Trp Arg Arg Cys 
1               5                   10                  15      


Leu Ala Ala Leu Leu Phe Gln Leu Leu Val Ala Val Cys Phe Phe Ser 
            20                  25                  30          


Tyr Leu Arg Val Ser Arg Asp Asp Ala Thr Gly Ser Pro Arg Ala Pro 
        35                  40                  45              


Ser Gly Ser Ser Arg Gln Asp Thr Thr Pro Thr Arg Pro Thr Leu Leu 
    50                  55                  60                  


Ile Leu Leu Arg Thr Trp Pro Phe His Ile Pro Val Ala Leu Ser Arg 
65                  70                  75                  80  


Cys Ser Glu Met Val Pro Gly Thr Ala Asp Cys His Ile Thr Ala Asp 
                85                  90                  95      


Arg Lys Val Tyr Pro Gln Ala Asp Met Val Ile Val His His Trp Asp 
            100                 105                 110         


Ile Met Ser Asn Pro Lys Ser Arg Leu Pro Pro Ser Pro Arg Pro Gln 
        115                 120                 125             


Gly Gln Arg Trp Ile Trp Phe Asn Leu Glu Pro Pro Pro Asn Cys Gln 
    130                 135                 140                 


His Leu Glu Ala Leu Asp Arg Tyr Phe Asn Leu Thr Met Ser Tyr Arg 
145                 150                 155                 160 


Ser Asp Ser Asp Ile Phe Thr Pro Tyr Gly Trp Leu Glu Pro Trp Ser 
                165                 170                 175     


Gly Gln Pro Ala His Pro Pro Leu Asn Leu Ser Ala Lys Thr Glu Leu 
            180                 185                 190         


Val Ala Trp Ala Val Ser Asn Trp Lys Pro Asp Ser Ala Arg Val Arg 
        195                 200                 205             


Tyr Tyr Gln Ser Leu Gln Ala His Leu Lys Val Asp Val Tyr Gly Arg 
    210                 215                 220                 


Ser His Lys Pro Leu Pro Lys Gly Thr Met Met Glu Thr Leu Ser Arg 
225                 230                 235                 240 


Tyr Lys Phe Tyr Leu Ala Phe Glu Asn Ser Leu His Pro Asp Tyr Ile 
                245                 250                 255     


Thr Glu Lys Leu Trp Arg Asn Ala Leu Glu Ala Trp Ala Val Pro Val 
            260                 265                 270         


Val Leu Gly Pro Ser Arg Ser Asn Tyr Glu Arg Phe Leu Pro Pro Asp 
        275                 280                 285             


Ala Phe Ile His Val Asp Asp Phe Gln Ser Pro Lys Asp Leu Ala Arg 
    290                 295                 300                 


Tyr Leu Gln Glu Leu Asp Lys Asp His Ala Arg Tyr Leu Ser Tyr Phe 
305                 310                 315                 320 


Arg Trp Arg Glu Thr Leu Arg Pro Arg Ser Phe Ser Trp Ala Leu Asp 
                325                 330                 335     


Phe Cys Lys Ala Cys Trp Lys Leu Gln Gln Glu Ser Arg Tyr Gln Thr 
            340                 345                 350         


Val Arg Ser Ile Ala Ala Trp Phe Thr 
        355                 360     

<210>  3369
<211>  2026
<212>  DNA
<213>  Homo sapiens

<400>  3369
aggaaacctg ccatggcctc ctggtgagct gtcctcatcc actgctcgct gcctctccag     60

atactctgac ccatggatcc cctgggtgca gccaagccac aatggccatg gcgccgctgt    120

ctggccgcac tgctatttca gctgctggtg gctgtgtgtt tcttctccta cctgcgtgtg    180

tcccgagacg atgccactgg atcccctagg gctcccagtg ggtcctcccg acaggacacc    240

actcccaccc gccccaccct cctgatcctg ctacggacat ggcctttcca catccctgtg    300

gctctgtccc gctgttcaga gatggtgccc ggcacagccg actgccacat cactgccgac    360

cgcaaggtgt acccacaggc agacatggtc atcgtgcacc actgggatat catgtccaac    420

cctaagtcac gcctcccacc ttccccgagg ccgcaggggc agcgctggat ctggttcaac    480

ttggagccac cccctaactg ccagcacctg gaagccctgg acagatactt caatctcacc    540

atgtcctacc gcagcgactc cgacatcttc acgccctacg gctggctgga gccgtggtcc    600

ggccagcctg cccacccacc gctcaacctc tcggccaaga ccgagctggt ggcctgggcg    660

gtgtccaact ggaagccgga ctcagccagg gtgcgctact accagagcct gcaggctcat    720

ctcaaggtgg acgtgtacgg acgctcccac aagcccctgc ccaaggggac catgatggag    780

acgctgtccc ggtacaagtt ctacctggcc ttcgagaact ccttgcaccc cgactacatc    840

accgagaagc tgtggaggaa cgccctggag gcctgggccg tgcccgtggt gctgggcccc    900

agcagaagca actacgagag gttcctgcca cccgacgcct tcatccacgt ggacgacttc    960

cagagcccca aggacctggc ccggtacctg caggagctgg acaaggacca cgcccgctac   1020

ctgagctact ttcgctggcg ggagacgctg cggcctcgct ccttcagctg ggcactggat   1080

ttctgcaagg cctgctggaa actgcagcag gaatccaggt accagacggt gcgcagcata   1140

gcggcttggt tcacctgaga ggccggcatg gtgcctgggc tgccgggaac ctcatctgcc   1200

tggggcctca cctgctggag tcctttgtgg ccaaccctct ctcttacctg ggacctcaca   1260

cgctgggctt cacggctgcc aggagcctct cccctccaga agacttgcct gctagggacc   1320

tcgcctgctg gggacctcgc ctgttgggga cctcacctgc tggggacctc acctgctggg   1380

gaccttggct gctggaggct gcacctactg aggatgtcgg cggtcgggga ctttacctgc   1440

tgggacctgc tcccagagac cttgccacac tgaatctcac ctgctgggga cctcaccctg   1500

gagggccctg ggccctgggg aactggctta cttggggccc cacccgggag tgatggttct   1560

ggctgatttg tttgtgatgt tgttagccgc ctgtgagggg tgcagagaga tcatcacggc   1620

acggtttcca gatgtaatac tgcaaggaaa aatgatgacg tgtctcctca ctctagaggg   1680

gttggtccca tgggttaaga gctcacccca ggttctcacc tcaggggtta agagctcaga   1740

gttcagacag gtccaagttc aagcccagga ccaccactta tagggtacag gtgggatcga   1800

ctgtaaatga ggacttctgg aacattccaa atattctggg gttgagggaa attgctgctg   1860

tctacaaaat gccaagggtg gacaggcgct gtggctcacg cctgtaatcc cagcactttg   1920

ggaggctgag gtaggaggat tgattgaggc caagagttaa agaccagcct ggtcaatata   1980

gcaagaccac gtctctaaat aaaaaataat aggccggcca ggcacg                  2026


<210>  3370
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  3370


Met Asp Pro Leu Gly Ala Ala Lys Pro Gln Trp Pro Trp Arg Arg Cys 
1               5                   10                  15      


Leu Ala Ala Leu Leu Phe Gln Leu Leu Val Ala Val Cys Phe Phe Ser 
            20                  25                  30          


Tyr Leu Arg Val Ser Arg Asp Asp Ala Thr Gly Ser Pro Arg Ala Pro 
        35                  40                  45              


Ser Gly Ser Ser Arg Gln Asp Thr Thr Pro Thr Arg Pro Thr Leu Leu 
    50                  55                  60                  


Ile Leu Leu Arg Thr Trp Pro Phe His Ile Pro Val Ala Leu Ser Arg 
65                  70                  75                  80  


Cys Ser Glu Met Val Pro Gly Thr Ala Asp Cys His Ile Thr Ala Asp 
                85                  90                  95      


Arg Lys Val Tyr Pro Gln Ala Asp Met Val Ile Val His His Trp Asp 
            100                 105                 110         


Ile Met Ser Asn Pro Lys Ser Arg Leu Pro Pro Ser Pro Arg Pro Gln 
        115                 120                 125             


Gly Gln Arg Trp Ile Trp Phe Asn Leu Glu Pro Pro Pro Asn Cys Gln 
    130                 135                 140                 


His Leu Glu Ala Leu Asp Arg Tyr Phe Asn Leu Thr Met Ser Tyr Arg 
145                 150                 155                 160 


Ser Asp Ser Asp Ile Phe Thr Pro Tyr Gly Trp Leu Glu Pro Trp Ser 
                165                 170                 175     


Gly Gln Pro Ala His Pro Pro Leu Asn Leu Ser Ala Lys Thr Glu Leu 
            180                 185                 190         


Val Ala Trp Ala Val Ser Asn Trp Lys Pro Asp Ser Ala Arg Val Arg 
        195                 200                 205             


Tyr Tyr Gln Ser Leu Gln Ala His Leu Lys Val Asp Val Tyr Gly Arg 
    210                 215                 220                 


Ser His Lys Pro Leu Pro Lys Gly Thr Met Met Glu Thr Leu Ser Arg 
225                 230                 235                 240 


Tyr Lys Phe Tyr Leu Ala Phe Glu Asn Ser Leu His Pro Asp Tyr Ile 
                245                 250                 255     


Thr Glu Lys Leu Trp Arg Asn Ala Leu Glu Ala Trp Ala Val Pro Val 
            260                 265                 270         


Val Leu Gly Pro Ser Arg Ser Asn Tyr Glu Arg Phe Leu Pro Pro Asp 
        275                 280                 285             


Ala Phe Ile His Val Asp Asp Phe Gln Ser Pro Lys Asp Leu Ala Arg 
    290                 295                 300                 


Tyr Leu Gln Glu Leu Asp Lys Asp His Ala Arg Tyr Leu Ser Tyr Phe 
305                 310                 315                 320 


Arg Trp Arg Glu Thr Leu Arg Pro Arg Ser Phe Ser Trp Ala Leu Asp 
                325                 330                 335     


Phe Cys Lys Ala Cys Trp Lys Leu Gln Gln Glu Ser Arg Tyr Gln Thr 
            340                 345                 350         


Val Arg Ser Ile Ala Ala Trp Phe Thr 
        355                 360     

<210>  3371
<211>  2187
<212>  DNA
<213>  Homo sapiens

<400>  3371
gttcccactt cctccccgcc ccaggaaacc tgccatggcc tcctggtgag ctgtcctcat     60

ccactgctcg ctgcctctcc aggtgaccta cagggagctc cgctcgacac tgcaaggctt    120

agaccagttc ggtccaacag agaaagcagg caaccaccat gtcatttgaa aacagtttca    180

tcgggatata attcgcaacc catacagtga atccatttaa gatactctga cccatggatc    240

ccctgggtgc agccaagcca caatggccat ggcgccgctg tctggccgca ctgctatttc    300

agctgctggt ggctgtgtgt ttcttctcct acctgcgtgt gtcccgagac gatgccactg    360

gatcccctag ggctcccagt gggtcctccc gacaggacac cactcccacc cgccccaccc    420

tcctgatcct gctacggaca tggcctttcc acatccctgt ggctctgtcc cgctgttcag    480

agatggtgcc cggcacagcc gactgccaca tcactgccga ccgcaaggtg tacccacagg    540

cagacatggt catcgtgcac cactgggata tcatgtccaa ccctaagtca cgcctcccac    600

cttccccgag gccgcagggg cagcgctgga tctggttcaa cttggagcca ccccctaact    660

gccagcacct ggaagccctg gacagatact tcaatctcac catgtcctac cgcagcgact    720

ccgacatctt cacgccctac ggctggctgg agccgtggtc cggccagcct gcccacccac    780

cgctcaacct ctcggccaag accgagctgg tggcctgggc ggtgtccaac tggaagccgg    840

actcagccag ggtgcgctac taccagagcc tgcaggctca tctcaaggtg gacgtgtacg    900

gacgctccca caagcccctg cccaagggga ccatgatgga gacgctgtcc cggtacaagt    960

tctacctggc cttcgagaac tccttgcacc ccgactacat caccgagaag ctgtggagga   1020

acgccctgga ggcctgggcc gtgcccgtgg tgctgggccc cagcagaagc aactacgaga   1080

ggttcctgcc acccgacgcc ttcatccacg tggacgactt ccagagcccc aaggacctgg   1140

cccggtacct gcaggagctg gacaaggacc acgcccgcta cctgagctac tttcgctggc   1200

gggagacgct gcggcctcgc tccttcagct gggcactgga tttctgcaag gcctgctgga   1260

aactgcagca ggaatccagg taccagacgg tgcgcagcat agcggcttgg ttcacctgag   1320

aggccggcat ggtgcctggg ctgccgggaa cctcatctgc ctggggcctc acctgctgga   1380

gtcctttgtg gccaaccctc tctcttacct gggacctcac acgctgggct tcacggctgc   1440

caggagcctc tcccctccag aagacttgcc tgctagggac ctcgcctgct ggggacctcg   1500

cctgttgggg acctcacctg ctggggacct cacctgctgg ggaccttggc tgctggaggc   1560

tgcacctact gaggatgtcg gcggtcgggg actttacctg ctgggacctg ctcccagaga   1620

ccttgccaca ctgaatctca cctgctgggg acctcaccct ggagggccct gggccctggg   1680

gaactggctt acttggggcc ccacccggga gtgatggttc tggctgattt gtttgtgatg   1740

ttgttagccg cctgtgaggg gtgcagagag atcatcacgg cacggtttcc agatgtaata   1800

ctgcaaggaa aaatgatgac gtgtctcctc actctagagg ggttggtccc atgggttaag   1860

agctcacccc aggttctcac ctcaggggtt aagagctcag agttcagaca ggtccaagtt   1920

caagcccagg accaccactt atagggtaca ggtgggatcg actgtaaatg aggacttctg   1980

gaacattcca aatattctgg ggttgaggga aattgctgct gtctacaaaa tgccaagggt   2040

ggacaggcgc tgtggctcac gcctgtaatc ccagcacttt gggaggctga ggtaggagga   2100

ttgattgagg ccaagagtta aagaccagcc tggtcaatat agcaagacca cgtctctaaa   2160

taaaaaataa taggccggcc aggcacg                                       2187


<210>  3372
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  3372


Met Asp Pro Leu Gly Ala Ala Lys Pro Gln Trp Pro Trp Arg Arg Cys 
1               5                   10                  15      


Leu Ala Ala Leu Leu Phe Gln Leu Leu Val Ala Val Cys Phe Phe Ser 
            20                  25                  30          


Tyr Leu Arg Val Ser Arg Asp Asp Ala Thr Gly Ser Pro Arg Ala Pro 
        35                  40                  45              


Ser Gly Ser Ser Arg Gln Asp Thr Thr Pro Thr Arg Pro Thr Leu Leu 
    50                  55                  60                  


Ile Leu Leu Arg Thr Trp Pro Phe His Ile Pro Val Ala Leu Ser Arg 
65                  70                  75                  80  


Cys Ser Glu Met Val Pro Gly Thr Ala Asp Cys His Ile Thr Ala Asp 
                85                  90                  95      


Arg Lys Val Tyr Pro Gln Ala Asp Met Val Ile Val His His Trp Asp 
            100                 105                 110         


Ile Met Ser Asn Pro Lys Ser Arg Leu Pro Pro Ser Pro Arg Pro Gln 
        115                 120                 125             


Gly Gln Arg Trp Ile Trp Phe Asn Leu Glu Pro Pro Pro Asn Cys Gln 
    130                 135                 140                 


His Leu Glu Ala Leu Asp Arg Tyr Phe Asn Leu Thr Met Ser Tyr Arg 
145                 150                 155                 160 


Ser Asp Ser Asp Ile Phe Thr Pro Tyr Gly Trp Leu Glu Pro Trp Ser 
                165                 170                 175     


Gly Gln Pro Ala His Pro Pro Leu Asn Leu Ser Ala Lys Thr Glu Leu 
            180                 185                 190         


Val Ala Trp Ala Val Ser Asn Trp Lys Pro Asp Ser Ala Arg Val Arg 
        195                 200                 205             


Tyr Tyr Gln Ser Leu Gln Ala His Leu Lys Val Asp Val Tyr Gly Arg 
    210                 215                 220                 


Ser His Lys Pro Leu Pro Lys Gly Thr Met Met Glu Thr Leu Ser Arg 
225                 230                 235                 240 


Tyr Lys Phe Tyr Leu Ala Phe Glu Asn Ser Leu His Pro Asp Tyr Ile 
                245                 250                 255     


Thr Glu Lys Leu Trp Arg Asn Ala Leu Glu Ala Trp Ala Val Pro Val 
            260                 265                 270         


Val Leu Gly Pro Ser Arg Ser Asn Tyr Glu Arg Phe Leu Pro Pro Asp 
        275                 280                 285             


Ala Phe Ile His Val Asp Asp Phe Gln Ser Pro Lys Asp Leu Ala Arg 
    290                 295                 300                 


Tyr Leu Gln Glu Leu Asp Lys Asp His Ala Arg Tyr Leu Ser Tyr Phe 
305                 310                 315                 320 


Arg Trp Arg Glu Thr Leu Arg Pro Arg Ser Phe Ser Trp Ala Leu Asp 
                325                 330                 335     


Phe Cys Lys Ala Cys Trp Lys Leu Gln Gln Glu Ser Arg Tyr Gln Thr 
            340                 345                 350         


Val Arg Ser Ile Ala Ala Trp Phe Thr 
        355                 360     

<210>  3373
<211>  2589
<212>  DNA
<213>  Homo sapiens

<400>  3373
gttcccactt cctccccgcc ccaggaaacc tgccatggcc tcctggtgag ctgtcctcat     60

ccactgctcg ctgcctctcc agatcttcag ttgcttcagg ccatttgaac gtatatgagc    120

cggtcgtagg ggatatgatg gcttagcttg ggctcagagg cctgaaaatc gcccccacca    180

atcacctgtt tcccccaatc taccctcctg aaggtcactg acaaagactt cattgtctcc    240

taggagaggc tgccatatat ccagggctga cgtaattcca tcttaatatc agttacatta    300

taaaaattta cctcgtgcct gaggccccag agcccaaggg tgcaaagcag taattggtca    360

aagttcaact tccctcccac tctgggctca ggctgtcccc tgagggcctg tgttttgagt    420

ctctttccag aaccttggtg tgaacttagg tcttggcgtc gggatccctt ttcgtcacac    480

tcaggtgacc tacagggagc tccgctcgac actgcaaggc ttagaccagt tcggtccaac    540

agagaaagca ggcaaccacc atgtcatttg aaaacagttt catcgggata taattcgcaa    600

cccatacagt gaatccattt aagatactct gacccatgga tcccctgggt gcagccaagc    660

cacaatggcc atggcgccgc tgtctggccg cactgctatt tcagctgctg gtggctgtgt    720

gtttcttctc ctacctgcgt gtgtcccgag acgatgccac tggatcccct agggctccca    780

gtgggtcctc ccgacaggac accactccca cccgccccac cctcctgatc ctgctacgga    840

catggccttt ccacatccct gtggctctgt cccgctgttc agagatggtg cccggcacag    900

ccgactgcca catcactgcc gaccgcaagg tgtacccaca ggcagacatg gtcatcgtgc    960

accactggga tatcatgtcc aaccctaagt cacgcctccc accttccccg aggccgcagg   1020

ggcagcgctg gatctggttc aacttggagc caccccctaa ctgccagcac ctggaagccc   1080

tggacagata cttcaatctc accatgtcct accgcagcga ctccgacatc ttcacgccct   1140

acggctggct ggagccgtgg tccggccagc ctgcccaccc accgctcaac ctctcggcca   1200

agaccgagct ggtggcctgg gcggtgtcca actggaagcc ggactcagcc agggtgcgct   1260

actaccagag cctgcaggct catctcaagg tggacgtgta cggacgctcc cacaagcccc   1320

tgcccaaggg gaccatgatg gagacgctgt cccggtacaa gttctacctg gccttcgaga   1380

actccttgca ccccgactac atcaccgaga agctgtggag gaacgccctg gaggcctggg   1440

ccgtgcccgt ggtgctgggc cccagcagaa gcaactacga gaggttcctg ccacccgacg   1500

ccttcatcca cgtggacgac ttccagagcc ccaaggacct ggcccggtac ctgcaggagc   1560

tggacaagga ccacgcccgc tacctgagct actttcgctg gcgggagacg ctgcggcctc   1620

gctccttcag ctgggcactg gatttctgca aggcctgctg gaaactgcag caggaatcca   1680

ggtaccagac ggtgcgcagc atagcggctt ggttcacctg agaggccggc atggtgcctg   1740

ggctgccggg aacctcatct gcctggggcc tcacctgctg gagtcctttg tggccaaccc   1800

tctctcttac ctgggacctc acacgctggg cttcacggct gccaggagcc tctcccctcc   1860

agaagacttg cctgctaggg acctcgcctg ctggggacct cgcctgttgg ggacctcacc   1920

tgctggggac ctcacctgct ggggaccttg gctgctggag gctgcaccta ctgaggatgt   1980

cggcggtcgg ggactttacc tgctgggacc tgctcccaga gaccttgcca cactgaatct   2040

cacctgctgg ggacctcacc ctggagggcc ctgggccctg gggaactggc ttacttgggg   2100

ccccacccgg gagtgatggt tctggctgat ttgtttgtga tgttgttagc cgcctgtgag   2160

gggtgcagag agatcatcac ggcacggttt ccagatgtaa tactgcaagg aaaaatgatg   2220

acgtgtctcc tcactctaga ggggttggtc ccatgggtta agagctcacc ccaggttctc   2280

acctcagggg ttaagagctc agagttcaga caggtccaag ttcaagccca ggaccaccac   2340

ttatagggta caggtgggat cgactgtaaa tgaggacttc tggaacattc caaatattct   2400

ggggttgagg gaaattgctg ctgtctacaa aatgccaagg gtggacaggc gctgtggctc   2460

acgcctgtaa tcccagcact ttgggaggct gaggtaggag gattgattga ggccaagagt   2520

taaagaccag cctggtcaat atagcaagac cacgtctcta aataaaaaat aataggccgg   2580

ccaggcacg                                                           2589


<210>  3374
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  3374


Met Asp Pro Leu Gly Ala Ala Lys Pro Gln Trp Pro Trp Arg Arg Cys 
1               5                   10                  15      


Leu Ala Ala Leu Leu Phe Gln Leu Leu Val Ala Val Cys Phe Phe Ser 
            20                  25                  30          


Tyr Leu Arg Val Ser Arg Asp Asp Ala Thr Gly Ser Pro Arg Ala Pro 
        35                  40                  45              


Ser Gly Ser Ser Arg Gln Asp Thr Thr Pro Thr Arg Pro Thr Leu Leu 
    50                  55                  60                  


Ile Leu Leu Arg Thr Trp Pro Phe His Ile Pro Val Ala Leu Ser Arg 
65                  70                  75                  80  


Cys Ser Glu Met Val Pro Gly Thr Ala Asp Cys His Ile Thr Ala Asp 
                85                  90                  95      


Arg Lys Val Tyr Pro Gln Ala Asp Met Val Ile Val His His Trp Asp 
            100                 105                 110         


Ile Met Ser Asn Pro Lys Ser Arg Leu Pro Pro Ser Pro Arg Pro Gln 
        115                 120                 125             


Gly Gln Arg Trp Ile Trp Phe Asn Leu Glu Pro Pro Pro Asn Cys Gln 
    130                 135                 140                 


His Leu Glu Ala Leu Asp Arg Tyr Phe Asn Leu Thr Met Ser Tyr Arg 
145                 150                 155                 160 


Ser Asp Ser Asp Ile Phe Thr Pro Tyr Gly Trp Leu Glu Pro Trp Ser 
                165                 170                 175     


Gly Gln Pro Ala His Pro Pro Leu Asn Leu Ser Ala Lys Thr Glu Leu 
            180                 185                 190         


Val Ala Trp Ala Val Ser Asn Trp Lys Pro Asp Ser Ala Arg Val Arg 
        195                 200                 205             


Tyr Tyr Gln Ser Leu Gln Ala His Leu Lys Val Asp Val Tyr Gly Arg 
    210                 215                 220                 


Ser His Lys Pro Leu Pro Lys Gly Thr Met Met Glu Thr Leu Ser Arg 
225                 230                 235                 240 


Tyr Lys Phe Tyr Leu Ala Phe Glu Asn Ser Leu His Pro Asp Tyr Ile 
                245                 250                 255     


Thr Glu Lys Leu Trp Arg Asn Ala Leu Glu Ala Trp Ala Val Pro Val 
            260                 265                 270         


Val Leu Gly Pro Ser Arg Ser Asn Tyr Glu Arg Phe Leu Pro Pro Asp 
        275                 280                 285             


Ala Phe Ile His Val Asp Asp Phe Gln Ser Pro Lys Asp Leu Ala Arg 
    290                 295                 300                 


Tyr Leu Gln Glu Leu Asp Lys Asp His Ala Arg Tyr Leu Ser Tyr Phe 
305                 310                 315                 320 


Arg Trp Arg Glu Thr Leu Arg Pro Arg Ser Phe Ser Trp Ala Leu Asp 
                325                 330                 335     


Phe Cys Lys Ala Cys Trp Lys Leu Gln Gln Glu Ser Arg Tyr Gln Thr 
            340                 345                 350         


Val Arg Ser Ile Ala Ala Trp Phe Thr 
        355                 360     

<210>  3375
<211>  2244
<212>  DNA
<213>  Homo sapiens

<400>  3375
tctgttccca cttcctcccc gccccaggaa acctgccatg gcctcctggt gagctgtcct     60

catccactgc tcgctgcctc tccagaacct tggtgtgaac ttaggtcttg gcgtcgggat    120

cccttttcgt cacactcagg tgacctacag ggagctccgc tcgacactgc aaggcttaga    180

ccagttcggt ccaacagaga aagcaggcaa ccaccatgtc atttgaaaac agtttcatcg    240

ggatataatt cgcaacccat acagtgaatc catttaagat actctgaccc atggatcccc    300

tgggtgcagc caagccacaa tggccatggc gccgctgtct ggccgcactg ctatttcagc    360

tgctggtggc tgtgtgtttc ttctcctacc tgcgtgtgtc ccgagacgat gccactggat    420

cccctagggc tcccagtggg tcctcccgac aggacaccac tcccacccgc cccaccctcc    480

tgatcctgct acggacatgg cctttccaca tccctgtggc tctgtcccgc tgttcagaga    540

tggtgcccgg cacagccgac tgccacatca ctgccgaccg caaggtgtac ccacaggcag    600

acatggtcat cgtgcaccac tgggatatca tgtccaaccc taagtcacgc ctcccacctt    660

ccccgaggcc gcaggggcag cgctggatct ggttcaactt ggagccaccc cctaactgcc    720

agcacctgga agccctggac agatacttca atctcaccat gtcctaccgc agcgactccg    780

acatcttcac gccctacggc tggctggagc cgtggtccgg ccagcctgcc cacccaccgc    840

tcaacctctc ggccaagacc gagctggtgg cctgggcggt gtccaactgg aagccggact    900

cagccagggt gcgctactac cagagcctgc aggctcatct caaggtggac gtgtacggac    960

gctcccacaa gcccctgccc aaggggacca tgatggagac gctgtcccgg tacaagttct   1020

acctggcctt cgagaactcc ttgcaccccg actacatcac cgagaagctg tggaggaacg   1080

ccctggaggc ctgggccgtg cccgtggtgc tgggccccag cagaagcaac tacgagaggt   1140

tcctgccacc cgacgccttc atccacgtgg acgacttcca gagccccaag gacctggccc   1200

ggtacctgca ggagctggac aaggaccacg cccgctacct gagctacttt cgctggcggg   1260

agacgctgcg gcctcgctcc ttcagctggg cactggattt ctgcaaggcc tgctggaaac   1320

tgcagcagga atccaggtac cagacggtgc gcagcatagc ggcttggttc acctgagagg   1380

ccggcatggt gcctgggctg ccgggaacct catctgcctg gggcctcacc tgctggagtc   1440

ctttgtggcc aaccctctct cttacctggg acctcacacg ctgggcttca cggctgccag   1500

gagcctctcc cctccagaag acttgcctgc tagggacctc gcctgctggg gacctcgcct   1560

gttggggacc tcacctgctg gggacctcac ctgctgggga ccttggctgc tggaggctgc   1620

acctactgag gatgtcggcg gtcggggact ttacctgctg ggacctgctc ccagagacct   1680

tgccacactg aatctcacct gctggggacc tcaccctgga gggccctggg ccctggggaa   1740

ctggcttact tggggcccca cccgggagtg atggttctgg ctgatttgtt tgtgatgttg   1800

ttagccgcct gtgaggggtg cagagagatc atcacggcac ggtttccaga tgtaatactg   1860

caaggaaaaa tgatgacgtg tctcctcact ctagaggggt tggtcccatg ggttaagagc   1920

tcaccccagg ttctcacctc aggggttaag agctcagagt tcagacaggt ccaagttcaa   1980

gcccaggacc accacttata gggtacaggt gggatcgact gtaaatgagg acttctggaa   2040

cattccaaat attctggggt tgagggaaat tgctgctgtc tacaaaatgc caagggtgga   2100

caggcgctgt ggctcacgcc tgtaatccca gcactttggg aggctgaggt aggaggattg   2160

attgaggcca agagttaaag accagcctgg tcaatatagc aagaccacgt ctctaaataa   2220

aaaataatag gccggccagg cacg                                          2244


<210>  3376
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  3376


Met Asp Pro Leu Gly Ala Ala Lys Pro Gln Trp Pro Trp Arg Arg Cys 
1               5                   10                  15      


Leu Ala Ala Leu Leu Phe Gln Leu Leu Val Ala Val Cys Phe Phe Ser 
            20                  25                  30          


Tyr Leu Arg Val Ser Arg Asp Asp Ala Thr Gly Ser Pro Arg Ala Pro 
        35                  40                  45              


Ser Gly Ser Ser Arg Gln Asp Thr Thr Pro Thr Arg Pro Thr Leu Leu 
    50                  55                  60                  


Ile Leu Leu Arg Thr Trp Pro Phe His Ile Pro Val Ala Leu Ser Arg 
65                  70                  75                  80  


Cys Ser Glu Met Val Pro Gly Thr Ala Asp Cys His Ile Thr Ala Asp 
                85                  90                  95      


Arg Lys Val Tyr Pro Gln Ala Asp Met Val Ile Val His His Trp Asp 
            100                 105                 110         


Ile Met Ser Asn Pro Lys Ser Arg Leu Pro Pro Ser Pro Arg Pro Gln 
        115                 120                 125             


Gly Gln Arg Trp Ile Trp Phe Asn Leu Glu Pro Pro Pro Asn Cys Gln 
    130                 135                 140                 


His Leu Glu Ala Leu Asp Arg Tyr Phe Asn Leu Thr Met Ser Tyr Arg 
145                 150                 155                 160 


Ser Asp Ser Asp Ile Phe Thr Pro Tyr Gly Trp Leu Glu Pro Trp Ser 
                165                 170                 175     


Gly Gln Pro Ala His Pro Pro Leu Asn Leu Ser Ala Lys Thr Glu Leu 
            180                 185                 190         


Val Ala Trp Ala Val Ser Asn Trp Lys Pro Asp Ser Ala Arg Val Arg 
        195                 200                 205             


Tyr Tyr Gln Ser Leu Gln Ala His Leu Lys Val Asp Val Tyr Gly Arg 
    210                 215                 220                 


Ser His Lys Pro Leu Pro Lys Gly Thr Met Met Glu Thr Leu Ser Arg 
225                 230                 235                 240 


Tyr Lys Phe Tyr Leu Ala Phe Glu Asn Ser Leu His Pro Asp Tyr Ile 
                245                 250                 255     


Thr Glu Lys Leu Trp Arg Asn Ala Leu Glu Ala Trp Ala Val Pro Val 
            260                 265                 270         


Val Leu Gly Pro Ser Arg Ser Asn Tyr Glu Arg Phe Leu Pro Pro Asp 
        275                 280                 285             


Ala Phe Ile His Val Asp Asp Phe Gln Ser Pro Lys Asp Leu Ala Arg 
    290                 295                 300                 


Tyr Leu Gln Glu Leu Asp Lys Asp His Ala Arg Tyr Leu Ser Tyr Phe 
305                 310                 315                 320 


Arg Trp Arg Glu Thr Leu Arg Pro Arg Ser Phe Ser Trp Ala Leu Asp 
                325                 330                 335     


Phe Cys Lys Ala Cys Trp Lys Leu Gln Gln Glu Ser Arg Tyr Gln Thr 
            340                 345                 350         


Val Arg Ser Ile Ala Ala Trp Phe Thr 
        355                 360     

<210>  3377
<211>  1786
<212>  DNA
<213>  Homo sapiens

<400>  3377
aggaaacctg ccatggcctc ctggtgagct gtcctcatcc actgctcgct gcctctccag     60

gtgacctaca gggagctccg ctcgacactg caaggcttag accagttcgg tccaacagag    120

aaagcaggca accaccatgt catttgaaaa cagtttcatc gggatataat tcgcaaccca    180

tacagtgaat ccatttaaga tactctgacc catggatccc ctgggtgcag ccaagccaca    240

atggccatgg cgccgctgtc tggccgcact gctatttcag ctgctggtgg ctgtgtgttt    300

cttctcctac ctgcgtgtgt cccgagacga tgccactgga tcccctaggg ctcccagtgg    360

gtcctcccga caggacacca ctcccacccg ccccaccctc ctgatcctgc tacggacatg    420

gcctttccac atccctgtgg ctctgtcccg ctgttcagag atggtgcccg gcacagccga    480

ctgccacatc actgccgacc gcaaggtgta cccacaggca gacatggtca tcgtgcacca    540

ctgggatatc atgtccaacc ctaagtcacg cctcccacct tccccgaggc cgcaggggca    600

gcgctggatc tggttcaact tggagccacc ccctaactgc cagcacctgg aagccctgga    660

cagatacttc aatctcacca tgtcctaccg cagcgactcc gacatcttca cgccctacgg    720

ctggctggag ccgtggtccg gccagcctgc ccacccaccg ctcaacctct cggccaagac    780

cgagctggtg gcctgggcgg tgtccaactg gaagccggac tcagccaggg tgcgctacta    840

ccagagcctg caggctcatc tcaaggtgga cgtgtacgga cgctcccaca agcccctgcc    900

caaggggacc atgatggaga cgctgtcccg gtacaagttc tacctggcct tcgagaactc    960

cttgcacccc gactacatca ccgagaagct gtggaggaac gccctggagg cctgggccgt   1020

gcccgtggtg ctgggcccca gcagaagcaa ctacgagagg ttcctgccac ccgacgcctt   1080

catccacgtg gacgacttcc agagccccaa ggacctggcc cggtacctgc aggagctgga   1140

caaggaccac gcccgctacc tgagctactt tcgctggcgg gagacgctgc ggcctcgctc   1200

cttcagctgg gcactggatt tctgcaaggc ctgctggaaa ctgcagcagg aatccaggta   1260

ccagacggtg cgcagcatag cggcttggtt cacctgagag gccggcatgg tgcctgggct   1320

gccgggaacc tcatctgcct ggggcctcac ctgctggagt cctttgtggc caaccctctc   1380

tcttacctgg gacctcacac gctgggcttc acggctgcca ggagcctctc ccctccagaa   1440

gacttgcctg ctagggacct cgcctgctgg ggacctcgcc tgttggggac ctcacctgct   1500

ggggacctca cctgctgggg accttggctg ctggaggctg cacctactga ggatgtcggc   1560

ggtcggggac tttacctgct gggacctgct cccagagacc ttgccacact gaatctcacc   1620

tgctggggac ctcaccctgg agggccctgg gccctgggga actggcttac ttggggcccc   1680

acccgggagt gatggttctg gctgatttgt ttgtgatgtt gttagccgcc tgtgaggggt   1740

gcagagagat catcacggca cggtttccag atgtaatact gcaagg                  1786


<210>  3378
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  3378


Met Asp Pro Leu Gly Ala Ala Lys Pro Gln Trp Pro Trp Arg Arg Cys 
1               5                   10                  15      


Leu Ala Ala Leu Leu Phe Gln Leu Leu Val Ala Val Cys Phe Phe Ser 
            20                  25                  30          


Tyr Leu Arg Val Ser Arg Asp Asp Ala Thr Gly Ser Pro Arg Ala Pro 
        35                  40                  45              


Ser Gly Ser Ser Arg Gln Asp Thr Thr Pro Thr Arg Pro Thr Leu Leu 
    50                  55                  60                  


Ile Leu Leu Arg Thr Trp Pro Phe His Ile Pro Val Ala Leu Ser Arg 
65                  70                  75                  80  


Cys Ser Glu Met Val Pro Gly Thr Ala Asp Cys His Ile Thr Ala Asp 
                85                  90                  95      


Arg Lys Val Tyr Pro Gln Ala Asp Met Val Ile Val His His Trp Asp 
            100                 105                 110         


Ile Met Ser Asn Pro Lys Ser Arg Leu Pro Pro Ser Pro Arg Pro Gln 
        115                 120                 125             


Gly Gln Arg Trp Ile Trp Phe Asn Leu Glu Pro Pro Pro Asn Cys Gln 
    130                 135                 140                 


His Leu Glu Ala Leu Asp Arg Tyr Phe Asn Leu Thr Met Ser Tyr Arg 
145                 150                 155                 160 


Ser Asp Ser Asp Ile Phe Thr Pro Tyr Gly Trp Leu Glu Pro Trp Ser 
                165                 170                 175     


Gly Gln Pro Ala His Pro Pro Leu Asn Leu Ser Ala Lys Thr Glu Leu 
            180                 185                 190         


Val Ala Trp Ala Val Ser Asn Trp Lys Pro Asp Ser Ala Arg Val Arg 
        195                 200                 205             


Tyr Tyr Gln Ser Leu Gln Ala His Leu Lys Val Asp Val Tyr Gly Arg 
    210                 215                 220                 


Ser His Lys Pro Leu Pro Lys Gly Thr Met Met Glu Thr Leu Ser Arg 
225                 230                 235                 240 


Tyr Lys Phe Tyr Leu Ala Phe Glu Asn Ser Leu His Pro Asp Tyr Ile 
                245                 250                 255     


Thr Glu Lys Leu Trp Arg Asn Ala Leu Glu Ala Trp Ala Val Pro Val 
            260                 265                 270         


Val Leu Gly Pro Ser Arg Ser Asn Tyr Glu Arg Phe Leu Pro Pro Asp 
        275                 280                 285             


Ala Phe Ile His Val Asp Asp Phe Gln Ser Pro Lys Asp Leu Ala Arg 
    290                 295                 300                 


Tyr Leu Gln Glu Leu Asp Lys Asp His Ala Arg Tyr Leu Ser Tyr Phe 
305                 310                 315                 320 


Arg Trp Arg Glu Thr Leu Arg Pro Arg Ser Phe Ser Trp Ala Leu Asp 
                325                 330                 335     


Phe Cys Lys Ala Cys Trp Lys Leu Gln Gln Glu Ser Arg Tyr Gln Thr 
            340                 345                 350         


Val Arg Ser Ile Ala Ala Trp Phe Thr 
        355                 360     

<210>  3379
<211>  2184
<212>  DNA
<213>  Homo sapiens

<400>  3379
gggtggggca gaaacagatc acaatggtgg aatgtcatca gctaaggcta ttttcacttc     60

ttttgtagat cttcagttgc ttcaggccat ttgaacgtat atgagccggt cgtaggggat    120

atgatggctt agcttgggct cagaggcctg aaaatcgccc ccaccaatca cctgtttccc    180

ccaatctacc ctcctgaagg tcactgacaa agacttcatt gtctcctagg agaggctgcc    240

atatatccag ggctgacgta attccatctt aatatcagtt acattataaa aatttacctc    300

gtgcctgagg ccccagagcc caagggtgca aagcagtaat tggtcaaagt tcaacttccc    360

tcccactctg ggctcaggct gtcccctgag ggcctgtgtt ttgagtctct ttccagaacc    420

ttggtgtgaa cttaggtctt ggcgtcggga tcccttttcg tcacactcag gtgacctaca    480

gggagctccg ctcgacactg caaggcttag accagttcgg tccaacagag aaagcaggca    540

accaccatgt catttgaaaa cagtttcatc gggatataat tcgcaaccca tacagtgaat    600

ccatttaaga tactctgacc catggatccc ctgggtgcag ccaagccaca atggccatgg    660

cgccgctgtc tggccgcact gctatttcag ctgctggtgg ctgtgtgttt cttctcctac    720

ctgcgtgtgt cccgagacga tgccactgga tcccctaggg ctcccagtgg gtcctcccga    780

caggacacca ctcccacccg ccccaccctc ctgatcctgc tacggacatg gcctttccac    840

atccctgtgg ctctgtcccg ctgttcagag atggtgcccg gcacagccga ctgccacatc    900

actgccgacc gcaaggtgta cccacaggca gacatggtca tcgtgcacca ctgggatatc    960

atgtccaacc ctaagtcacg cctcccacct tccccgaggc cgcaggggca gcgctggatc   1020

tggttcaact tggagccacc ccctaactgc cagcacctgg aagccctgga cagatacttc   1080

aatctcacca tgtcctaccg cagcgactcc gacatcttca cgccctacgg ctggctggag   1140

ccgtggtccg gccagcctgc ccacccaccg ctcaacctct cggccaagac cgagctggtg   1200

gcctgggcgg tgtccaactg gaagccggac tcagccaggg tgcgctacta ccagagcctg   1260

caggctcatc tcaaggtgga cgtgtacgga cgctcccaca agcccctgcc caaggggacc   1320

atgatggaga cgctgtcccg gtacaagttc tacctggcct tcgagaactc cttgcacccc   1380

gactacatca ccgagaagct gtggaggaac gccctggagg cctgggccgt gcccgtggtg   1440

ctgggcccca gcagaagcaa ctacgagagg ttcctgccac ccgacgcctt catccacgtg   1500

gacgacttcc agagccccaa ggacctggcc cggtacctgc aggagctgga caaggaccac   1560

gcccgctacc tgagctactt tcgctggcgg gagacgctgc ggcctcgctc cttcagctgg   1620

gcactggatt tctgcaaggc ctgctggaaa ctgcagcagg aatccaggta ccagacggtg   1680

cgcagcatag cggcttggtt cacctgagag gccggcatgg tgcctgggct gccgggaacc   1740

tcatctgcct ggggcctcac ctgctggagt cctttgtggc caaccctctc tcttacctgg   1800

gacctcacac gctgggcttc acggctgcca ggagcctctc ccctccagaa gacttgcctg   1860

ctagggacct cgcctgctgg ggacctcgcc tgttggggac ctcacctgct ggggacctca   1920

cctgctgggg accttggctg ctggaggctg cacctactga ggatgtcggc ggtcggggac   1980

tttacctgct gggacctgct cccagagacc ttgccacact gaatctcacc tgctggggac   2040

ctcaccctgg agggccctgg gccctgggga actggcttac ttggggcccc acccgggagt   2100

gatggttctg gctgatttgt ttgtgatgtt gttagccgcc tgtgaggggt gcagagagat   2160

catcacggca cggtttccag atgt                                          2184


<210>  3380
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  3380


Met Asp Pro Leu Gly Ala Ala Lys Pro Gln Trp Pro Trp Arg Arg Cys 
1               5                   10                  15      


Leu Ala Ala Leu Leu Phe Gln Leu Leu Val Ala Val Cys Phe Phe Ser 
            20                  25                  30          


Tyr Leu Arg Val Ser Arg Asp Asp Ala Thr Gly Ser Pro Arg Ala Pro 
        35                  40                  45              


Ser Gly Ser Ser Arg Gln Asp Thr Thr Pro Thr Arg Pro Thr Leu Leu 
    50                  55                  60                  


Ile Leu Leu Arg Thr Trp Pro Phe His Ile Pro Val Ala Leu Ser Arg 
65                  70                  75                  80  


Cys Ser Glu Met Val Pro Gly Thr Ala Asp Cys His Ile Thr Ala Asp 
                85                  90                  95      


Arg Lys Val Tyr Pro Gln Ala Asp Met Val Ile Val His His Trp Asp 
            100                 105                 110         


Ile Met Ser Asn Pro Lys Ser Arg Leu Pro Pro Ser Pro Arg Pro Gln 
        115                 120                 125             


Gly Gln Arg Trp Ile Trp Phe Asn Leu Glu Pro Pro Pro Asn Cys Gln 
    130                 135                 140                 


His Leu Glu Ala Leu Asp Arg Tyr Phe Asn Leu Thr Met Ser Tyr Arg 
145                 150                 155                 160 


Ser Asp Ser Asp Ile Phe Thr Pro Tyr Gly Trp Leu Glu Pro Trp Ser 
                165                 170                 175     


Gly Gln Pro Ala His Pro Pro Leu Asn Leu Ser Ala Lys Thr Glu Leu 
            180                 185                 190         


Val Ala Trp Ala Val Ser Asn Trp Lys Pro Asp Ser Ala Arg Val Arg 
        195                 200                 205             


Tyr Tyr Gln Ser Leu Gln Ala His Leu Lys Val Asp Val Tyr Gly Arg 
    210                 215                 220                 


Ser His Lys Pro Leu Pro Lys Gly Thr Met Met Glu Thr Leu Ser Arg 
225                 230                 235                 240 


Tyr Lys Phe Tyr Leu Ala Phe Glu Asn Ser Leu His Pro Asp Tyr Ile 
                245                 250                 255     


Thr Glu Lys Leu Trp Arg Asn Ala Leu Glu Ala Trp Ala Val Pro Val 
            260                 265                 270         


Val Leu Gly Pro Ser Arg Ser Asn Tyr Glu Arg Phe Leu Pro Pro Asp 
        275                 280                 285             


Ala Phe Ile His Val Asp Asp Phe Gln Ser Pro Lys Asp Leu Ala Arg 
    290                 295                 300                 


Tyr Leu Gln Glu Leu Asp Lys Asp His Ala Arg Tyr Leu Ser Tyr Phe 
305                 310                 315                 320 


Arg Trp Arg Glu Thr Leu Arg Pro Arg Ser Phe Ser Trp Ala Leu Asp 
                325                 330                 335     


Phe Cys Lys Ala Cys Trp Lys Leu Gln Gln Glu Ser Arg Tyr Gln Thr 
            340                 345                 350         


Val Arg Ser Ile Ala Ala Trp Phe Thr 
        355                 360     

<210>  3381
<211>  1844
<212>  DNA
<213>  Homo sapiens

<400>  3381
gtgcctttag ctccagccac ctctttaaga ggaaactgtt gggcagatgg aggagggcta     60

gtcacggaaa gaaactaacc ttggtgtgaa cttaggtctt ggcgtcggga tcccttttcg    120

tcacactcag gtgacctaca gggagctccg ctcgacactg caaggcttag accagttcgg    180

tccaacagag aaagcaggca accaccatgt catttgaaaa cagtttcatc gggatataat    240

tcgcaaccca tacagtgaat ccatttaaga tactctgacc catggatccc ctgggtgcag    300

ccaagccaca atggccatgg cgccgctgtc tggccgcact gctatttcag ctgctggtgg    360

ctgtgtgttt cttctcctac ctgcgtgtgt cccgagacga tgccactgga tcccctaggg    420

ctcccagtgg gtcctcccga caggacacca ctcccacccg ccccaccctc ctgatcctgc    480

tacggacatg gcctttccac atccctgtgg ctctgtcccg ctgttcagag atggtgcccg    540

gcacagccga ctgccacatc actgccgacc gcaaggtgta cccacaggca gacatggtca    600

tcgtgcacca ctgggatatc atgtccaacc ctaagtcacg cctcccacct tccccgaggc    660

cgcaggggca gcgctggatc tggttcaact tggagccacc ccctaactgc cagcacctgg    720

aagccctgga cagatacttc aatctcacca tgtcctaccg cagcgactcc gacatcttca    780

cgccctacgg ctggctggag ccgtggtccg gccagcctgc ccacccaccg ctcaacctct    840

cggccaagac cgagctggtg gcctgggcgg tgtccaactg gaagccggac tcagccaggg    900

tgcgctacta ccagagcctg caggctcatc tcaaggtgga cgtgtacgga cgctcccaca    960

agcccctgcc caaggggacc atgatggaga cgctgtcccg gtacaagttc tacctggcct   1020

tcgagaactc cttgcacccc gactacatca ccgagaagct gtggaggaac gccctggagg   1080

cctgggccgt gcccgtggtg ctgggcccca gcagaagcaa ctacgagagg ttcctgccac   1140

ccgacgcctt catccacgtg gacgacttcc agagccccaa ggacctggcc cggtacctgc   1200

aggagctgga caaggaccac gcccgctacc tgagctactt tcgctggcgg gagacgctgc   1260

ggcctcgctc cttcagctgg gcactggatt tctgcaaggc ctgctggaaa ctgcagcagg   1320

aatccaggta ccagacggtg cgcagcatag cggcttggtt cacctgagag gccggcatgg   1380

tgcctgggct gccgggaacc tcatctgcct ggggcctcac ctgctggagt cctttgtggc   1440

caaccctctc tcttacctgg gacctcacac gctgggcttc acggctgcca ggagcctctc   1500

ccctccagaa gacttgcctg ctagggacct cgcctgctgg ggacctcgcc tgttggggac   1560

ctcacctgct ggggacctca cctgctgggg accttggctg ctggaggctg cacctactga   1620

ggatgtcggc ggtcggggac tttacctgct gggacctgct cccagagacc ttgccacact   1680

gaatctcacc tgctggggac ctcaccctgg agggccctgg gccctgggga actggcttac   1740

ttggggcccc acccgggagt gatggttctg gctgatttgt ttgtgatgtt gttagccgcc   1800

tgtgaggggt gcagagagat catcacggca cggtttccag atgt                    1844


<210>  3382
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  3382


Met Asp Pro Leu Gly Ala Ala Lys Pro Gln Trp Pro Trp Arg Arg Cys 
1               5                   10                  15      


Leu Ala Ala Leu Leu Phe Gln Leu Leu Val Ala Val Cys Phe Phe Ser 
            20                  25                  30          


Tyr Leu Arg Val Ser Arg Asp Asp Ala Thr Gly Ser Pro Arg Ala Pro 
        35                  40                  45              


Ser Gly Ser Ser Arg Gln Asp Thr Thr Pro Thr Arg Pro Thr Leu Leu 
    50                  55                  60                  


Ile Leu Leu Arg Thr Trp Pro Phe His Ile Pro Val Ala Leu Ser Arg 
65                  70                  75                  80  


Cys Ser Glu Met Val Pro Gly Thr Ala Asp Cys His Ile Thr Ala Asp 
                85                  90                  95      


Arg Lys Val Tyr Pro Gln Ala Asp Met Val Ile Val His His Trp Asp 
            100                 105                 110         


Ile Met Ser Asn Pro Lys Ser Arg Leu Pro Pro Ser Pro Arg Pro Gln 
        115                 120                 125             


Gly Gln Arg Trp Ile Trp Phe Asn Leu Glu Pro Pro Pro Asn Cys Gln 
    130                 135                 140                 


His Leu Glu Ala Leu Asp Arg Tyr Phe Asn Leu Thr Met Ser Tyr Arg 
145                 150                 155                 160 


Ser Asp Ser Asp Ile Phe Thr Pro Tyr Gly Trp Leu Glu Pro Trp Ser 
                165                 170                 175     


Gly Gln Pro Ala His Pro Pro Leu Asn Leu Ser Ala Lys Thr Glu Leu 
            180                 185                 190         


Val Ala Trp Ala Val Ser Asn Trp Lys Pro Asp Ser Ala Arg Val Arg 
        195                 200                 205             


Tyr Tyr Gln Ser Leu Gln Ala His Leu Lys Val Asp Val Tyr Gly Arg 
    210                 215                 220                 


Ser His Lys Pro Leu Pro Lys Gly Thr Met Met Glu Thr Leu Ser Arg 
225                 230                 235                 240 


Tyr Lys Phe Tyr Leu Ala Phe Glu Asn Ser Leu His Pro Asp Tyr Ile 
                245                 250                 255     


Thr Glu Lys Leu Trp Arg Asn Ala Leu Glu Ala Trp Ala Val Pro Val 
            260                 265                 270         


Val Leu Gly Pro Ser Arg Ser Asn Tyr Glu Arg Phe Leu Pro Pro Asp 
        275                 280                 285             


Ala Phe Ile His Val Asp Asp Phe Gln Ser Pro Lys Asp Leu Ala Arg 
    290                 295                 300                 


Tyr Leu Gln Glu Leu Asp Lys Asp His Ala Arg Tyr Leu Ser Tyr Phe 
305                 310                 315                 320 


Arg Trp Arg Glu Thr Leu Arg Pro Arg Ser Phe Ser Trp Ala Leu Asp 
                325                 330                 335     


Phe Cys Lys Ala Cys Trp Lys Leu Gln Gln Glu Ser Arg Tyr Gln Thr 
            340                 345                 350         


Val Arg Ser Ile Ala Ala Trp Phe Thr 
        355                 360     

<210>  3383
<211>  1635
<212>  DNA
<213>  Homo sapiens

<400>  3383
aggaaacctg ccatggcctc ctggtgagct gtcctcatcc actgctcgct gcctctccag     60

atactctgac ccatggatcc cctgggtgca gccaagccac aatggccatg gcgccgctgt    120

ctggccgcac tgctatttca gctgctggtg gctgtgtgtt tcttctccta cctgcgtgtg    180

tcccgagacg atgccactgg atcccctagg gctcccagtg ggtcctcccg acaggacacc    240

actcccaccc gccccaccct cctgatcctg ctacggacat ggcctttcca catccctgtg    300

gctctgtccc gctgttcaga gatggtgccc ggcacagccg actgccacat cactgccgac    360

cgcaaggtgt acccacaggc agacatggtc atcgtgcacc actgggatat catgtccaac    420

cctaagtcac gcctcccacc ttccccgagg ccgcaggggc agcgctggat ctggttcaac    480

ttggagccac cccctaactg ccagcacctg gaagccctgg acagatactt caatctcacc    540

atgtcctacc gcagcgactc cgacatcttc acgccctacg gctggctgga gccgtggtcc    600

ggccagcctg cccacccacc gctcaacctc tcggccaaga ccgagctggt ggcctgggcg    660

gtgtccaact ggaagccgga ctcagccagg gtgcgctact accagagcct gcaggctcat    720

ctcaaggtgg acgtgtacgg acgctcccac aagcccctgc ccaaggggac catgatggag    780

acgctgtccc ggtacaagtt ctacctggcc ttcgagaact ccttgcaccc cgactacatc    840

accgagaagc tgtggaggaa cgccctggag gcctgggccg tgcccgtggt gctgggcccc    900

agcagaagca actacgagag gttcctgcca cccgacgcct tcatccacgt ggacgacttc    960

cagagcccca aggacctggc ccggtacctg caggagctgg acaaggacca cgcccgctac   1020

ctgagctact ttcgctggcg ggagacgctg cggcctcgct ccttcagctg ggcactggat   1080

ttctgcaagg cctgctggaa actgcagcag gaatccaggt accagacggt gcgcagcata   1140

gcggcttggt tcacctgaga ggccggcatg gtgcctgggc tgccgggaac ctcatctgcc   1200

tggggcctca cctgctggag tcctttgtgg ccaaccctct ctcttacctg ggacctcaca   1260

cgctgggctt cacggctgcc aggagcctct cccctccaga agacttgcct gctagggacc   1320

tcgcctgctg gggacctcgc ctgttgggga cctcacctgc tggggacctc acctgctggg   1380

gaccttggct gctggaggct gcacctactg aggatgtcgg cggtcgggga ctttacctgc   1440

tgggacctgc tcccagagac cttgccacac tgaatctcac ctgctgggga cctcaccctg   1500

gagggccctg ggccctgggg aactggctta cttggggccc cacccgggag tgatggttct   1560

ggctgatttg tttgtgatgt tgttagccgc ctgtgagggg tgcagagaga tcatcacggc   1620

acggtttcca gatgt                                                    1635


<210>  3384
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  3384


Met Asp Pro Leu Gly Ala Ala Lys Pro Gln Trp Pro Trp Arg Arg Cys 
1               5                   10                  15      


Leu Ala Ala Leu Leu Phe Gln Leu Leu Val Ala Val Cys Phe Phe Ser 
            20                  25                  30          


Tyr Leu Arg Val Ser Arg Asp Asp Ala Thr Gly Ser Pro Arg Ala Pro 
        35                  40                  45              


Ser Gly Ser Ser Arg Gln Asp Thr Thr Pro Thr Arg Pro Thr Leu Leu 
    50                  55                  60                  


Ile Leu Leu Arg Thr Trp Pro Phe His Ile Pro Val Ala Leu Ser Arg 
65                  70                  75                  80  


Cys Ser Glu Met Val Pro Gly Thr Ala Asp Cys His Ile Thr Ala Asp 
                85                  90                  95      


Arg Lys Val Tyr Pro Gln Ala Asp Met Val Ile Val His His Trp Asp 
            100                 105                 110         


Ile Met Ser Asn Pro Lys Ser Arg Leu Pro Pro Ser Pro Arg Pro Gln 
        115                 120                 125             


Gly Gln Arg Trp Ile Trp Phe Asn Leu Glu Pro Pro Pro Asn Cys Gln 
    130                 135                 140                 


His Leu Glu Ala Leu Asp Arg Tyr Phe Asn Leu Thr Met Ser Tyr Arg 
145                 150                 155                 160 


Ser Asp Ser Asp Ile Phe Thr Pro Tyr Gly Trp Leu Glu Pro Trp Ser 
                165                 170                 175     


Gly Gln Pro Ala His Pro Pro Leu Asn Leu Ser Ala Lys Thr Glu Leu 
            180                 185                 190         


Val Ala Trp Ala Val Ser Asn Trp Lys Pro Asp Ser Ala Arg Val Arg 
        195                 200                 205             


Tyr Tyr Gln Ser Leu Gln Ala His Leu Lys Val Asp Val Tyr Gly Arg 
    210                 215                 220                 


Ser His Lys Pro Leu Pro Lys Gly Thr Met Met Glu Thr Leu Ser Arg 
225                 230                 235                 240 


Tyr Lys Phe Tyr Leu Ala Phe Glu Asn Ser Leu His Pro Asp Tyr Ile 
                245                 250                 255     


Thr Glu Lys Leu Trp Arg Asn Ala Leu Glu Ala Trp Ala Val Pro Val 
            260                 265                 270         


Val Leu Gly Pro Ser Arg Ser Asn Tyr Glu Arg Phe Leu Pro Pro Asp 
        275                 280                 285             


Ala Phe Ile His Val Asp Asp Phe Gln Ser Pro Lys Asp Leu Ala Arg 
    290                 295                 300                 


Tyr Leu Gln Glu Leu Asp Lys Asp His Ala Arg Tyr Leu Ser Tyr Phe 
305                 310                 315                 320 


Arg Trp Arg Glu Thr Leu Arg Pro Arg Ser Phe Ser Trp Ala Leu Asp 
                325                 330                 335     


Phe Cys Lys Ala Cys Trp Lys Leu Gln Gln Glu Ser Arg Tyr Gln Thr 
            340                 345                 350         


Val Arg Ser Ile Ala Ala Trp Phe Thr 
        355                 360     

<210>  3385
<211>  1853
<212>  DNA
<213>  Homo sapiens

<400>  3385
tctgttccca cttcctcccc gccccaggaa acctgccatg gcctcctggt gagctgtcct     60

catccactgc tcgctgcctc tccagaacct tggtgtgaac ttaggtcttg gcgtcgggat    120

cccttttcgt cacactcagg tgacctacag ggagctccgc tcgacactgc aaggcttaga    180

ccagttcggt ccaacagaga aagcaggcaa ccaccatgtc atttgaaaac agtttcatcg    240

ggatataatt cgcaacccat acagtgaatc catttaagat actctgaccc atggatcccc    300

tgggtgcagc caagccacaa tggccatggc gccgctgtct ggccgcactg ctatttcagc    360

tgctggtggc tgtgtgtttc ttctcctacc tgcgtgtgtc ccgagacgat gccactggat    420

cccctagggc tcccagtggg tcctcccgac aggacaccac tcccacccgc cccaccctcc    480

tgatcctgct acggacatgg cctttccaca tccctgtggc tctgtcccgc tgttcagaga    540

tggtgcccgg cacagccgac tgccacatca ctgccgaccg caaggtgtac ccacaggcag    600

acatggtcat cgtgcaccac tgggatatca tgtccaaccc taagtcacgc ctcccacctt    660

ccccgaggcc gcaggggcag cgctggatct ggttcaactt ggagccaccc cctaactgcc    720

agcacctgga agccctggac agatacttca atctcaccat gtcctaccgc agcgactccg    780

acatcttcac gccctacggc tggctggagc cgtggtccgg ccagcctgcc cacccaccgc    840

tcaacctctc ggccaagacc gagctggtgg cctgggcggt gtccaactgg aagccggact    900

cagccagggt gcgctactac cagagcctgc aggctcatct caaggtggac gtgtacggac    960

gctcccacaa gcccctgccc aaggggacca tgatggagac gctgtcccgg tacaagttct   1020

acctggcctt cgagaactcc ttgcaccccg actacatcac cgagaagctg tggaggaacg   1080

ccctggaggc ctgggccgtg cccgtggtgc tgggccccag cagaagcaac tacgagaggt   1140

tcctgccacc cgacgccttc atccacgtgg acgacttcca gagccccaag gacctggccc   1200

ggtacctgca ggagctggac aaggaccacg cccgctacct gagctacttt cgctggcggg   1260

agacgctgcg gcctcgctcc ttcagctggg cactggattt ctgcaaggcc tgctggaaac   1320

tgcagcagga atccaggtac cagacggtgc gcagcatagc ggcttggttc acctgagagg   1380

ccggcatggt gcctgggctg ccgggaacct catctgcctg gggcctcacc tgctggagtc   1440

ctttgtggcc aaccctctct cttacctggg acctcacacg ctgggcttca cggctgccag   1500

gagcctctcc cctccagaag acttgcctgc tagggacctc gcctgctggg gacctcgcct   1560

gttggggacc tcacctgctg gggacctcac ctgctgggga ccttggctgc tggaggctgc   1620

acctactgag gatgtcggcg gtcggggact ttacctgctg ggacctgctc ccagagacct   1680

tgccacactg aatctcacct gctggggacc tcaccctgga gggccctggg ccctggggaa   1740

ctggcttact tggggcccca cccgggagtg atggttctgg ctgatttgtt tgtgatgttg   1800

ttagccgcct gtgaggggtg cagagagatc atcacggcac ggtttccaga tgt          1853


<210>  3386
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  3386


Met Asp Pro Leu Gly Ala Ala Lys Pro Gln Trp Pro Trp Arg Arg Cys 
1               5                   10                  15      


Leu Ala Ala Leu Leu Phe Gln Leu Leu Val Ala Val Cys Phe Phe Ser 
            20                  25                  30          


Tyr Leu Arg Val Ser Arg Asp Asp Ala Thr Gly Ser Pro Arg Ala Pro 
        35                  40                  45              


Ser Gly Ser Ser Arg Gln Asp Thr Thr Pro Thr Arg Pro Thr Leu Leu 
    50                  55                  60                  


Ile Leu Leu Arg Thr Trp Pro Phe His Ile Pro Val Ala Leu Ser Arg 
65                  70                  75                  80  


Cys Ser Glu Met Val Pro Gly Thr Ala Asp Cys His Ile Thr Ala Asp 
                85                  90                  95      


Arg Lys Val Tyr Pro Gln Ala Asp Met Val Ile Val His His Trp Asp 
            100                 105                 110         


Ile Met Ser Asn Pro Lys Ser Arg Leu Pro Pro Ser Pro Arg Pro Gln 
        115                 120                 125             


Gly Gln Arg Trp Ile Trp Phe Asn Leu Glu Pro Pro Pro Asn Cys Gln 
    130                 135                 140                 


His Leu Glu Ala Leu Asp Arg Tyr Phe Asn Leu Thr Met Ser Tyr Arg 
145                 150                 155                 160 


Ser Asp Ser Asp Ile Phe Thr Pro Tyr Gly Trp Leu Glu Pro Trp Ser 
                165                 170                 175     


Gly Gln Pro Ala His Pro Pro Leu Asn Leu Ser Ala Lys Thr Glu Leu 
            180                 185                 190         


Val Ala Trp Ala Val Ser Asn Trp Lys Pro Asp Ser Ala Arg Val Arg 
        195                 200                 205             


Tyr Tyr Gln Ser Leu Gln Ala His Leu Lys Val Asp Val Tyr Gly Arg 
    210                 215                 220                 


Ser His Lys Pro Leu Pro Lys Gly Thr Met Met Glu Thr Leu Ser Arg 
225                 230                 235                 240 


Tyr Lys Phe Tyr Leu Ala Phe Glu Asn Ser Leu His Pro Asp Tyr Ile 
                245                 250                 255     


Thr Glu Lys Leu Trp Arg Asn Ala Leu Glu Ala Trp Ala Val Pro Val 
            260                 265                 270         


Val Leu Gly Pro Ser Arg Ser Asn Tyr Glu Arg Phe Leu Pro Pro Asp 
        275                 280                 285             


Ala Phe Ile His Val Asp Asp Phe Gln Ser Pro Lys Asp Leu Ala Arg 
    290                 295                 300                 


Tyr Leu Gln Glu Leu Asp Lys Asp His Ala Arg Tyr Leu Ser Tyr Phe 
305                 310                 315                 320 


Arg Trp Arg Glu Thr Leu Arg Pro Arg Ser Phe Ser Trp Ala Leu Asp 
                325                 330                 335     


Phe Cys Lys Ala Cys Trp Lys Leu Gln Gln Glu Ser Arg Tyr Gln Thr 
            340                 345                 350         


Val Arg Ser Ile Ala Ala Trp Phe Thr 
        355                 360     

<210>  3387
<211>  888
<212>  DNA
<213>  Homo sapiens

<400>  3387
gctttttgct tcctgatctt tgtgatgtct cagcagagta gcatttttta atctttttct     60

aggaaaaaat atcttgggtt caactggggt gggatctcag tcctcatcgc gatctcacat    120

gtctgtgtga agagaccacc aaacaggctt tgtaattatt ggtgatggcc tggatgcggt    180

tttgtatgaa ctgagaaact aaacaaaaga gtggctgcca ggtggatctc ttcagggagt    240

gaaggtgagg acaggggact gctgtcccga aggagtcccg ctgacccggg tcttcggcac    300

caaatgtctc atgcgtccgt gtgaagagac caccaaacag gctttgtatc ttcagttgct    360

tcaggccatt tgaacgtata tgagccggtc gtaggggata tgatggctta gcttgggctc    420

agaggcctga aaatcgcccc caccaatcac ctgtttcccc caatctaccc tcctgaaggt    480

cactgacaaa gacttcattg tctcctagga gaggctgcca tatatccagg gctgacgtaa    540

ttccatctta atatcagtta cattataaaa atttacctcg tgcctgaggc cccagagccc    600

aagggtgcaa agcagtaatt ggtcaaagtt caacttccct cccactctgg gctcaggctg    660

tcccctgagg gcctgtgttt tgagtctctt tccagaacct tggtgtgaac ttaggtcttg    720

gcgtcgggat cccttttcgt cacactcagg tgacctacag ggagctccgc tcgacactgc    780

aaggcttaga ccagttcggt ccaacagaga aagcaggcaa ccaccatgtc atttgaaaac    840

agtttcatcg ggatataatt cgcaacccat acagtgaatc catttaag                 888


<210>  3388
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  3388


Ser Phe Ser Arg Lys Lys Tyr Leu Gly Phe Asn Trp Gly Gly Ile Ser 
1               5                   10                  15      


Val Leu Ile Ala Ile Ser His Val Cys Val Lys Arg Pro Pro Asn Arg 
            20                  25                  30          


Leu Cys Asn Tyr Trp 
        35          

<210>  3389
<211>  1988
<212>  DNA
<213>  Homo sapiens

<400>  3389
gattacagac atgagccacc tcgcccagcc ttttcatggc tgagtgatat tccattgtgt     60

ggatggatca cactagctac tctgacccat ggatcccctg ggcccagcca agccacagtg    120

gctgtggcgc cgctgtctgg ccgggctgct gtttcagctg ctggtggctg tgtgtttctt    180

ctcctacctg cgtgtgtccc gagacgatgc cactggatcc cctaggccag ggcttatggc    240

agtggaacct gtcaccgggg ctcccaatgg gtcccgctgc caggacagca tggcgacccc    300

tgcccacccc accctactga tcctgctgtg gacgtggcct tttaacacac ccgtggctct    360

gccccgctgc tcagagatgg tgcccggcgc ggccgactgc aacatcactg ccgactccag    420

tgtgtaccca caggcagacg cggtcatcgt gcaccactgg gatatcatgt acaaccccag    480

tgccaacctc ccgcccccca ccaggccgca ggggcagcgc tggatctggt tcagcatgga    540

gtcccccagc aactgccggc acctggaagc cctggacgga tacttcaatc tcaccatgtc    600

ctaccgcagc gactccgaca tcttcacgcc ctacggctgg ctggagccgt ggtccggcca    660

gcctgcccac ccaccgctca acctctcggc caagaccgag ctggtggcct gggcggtgtc    720

caactggaag ccggactcgg ccagggtgcg ctactaccag agcctgcagg ctcatctcaa    780

ggtggacgtg tacggacgct cccacaagcc cctgcccaag gggaccatga tggagacgct    840

gtcccggtac aagttctatc tggccttcga gaactccttg caccccgact acatcaccga    900

gaagctgtgg aggaacgccc tggaggcctg ggccgtgccc gtggtgctgg gccccagcag    960

aagcaactac gagaggttcc tgccacccga cgccttcatc cacgtggacg acttccagag   1020

ccccaaggac ctggcccggt acctgcagga gctggacaag gaccacgccc gctacctgag   1080

ctactttcac tggcgggaga cgctgcggcc tcgctccttc agctgggcac tggctttctg   1140

caaggcctgc tggaagctgc agcaggaatc taggtaccag acggtgcgca gcatagcggc   1200

ttggttcacc tgagaggccg gcatggggcc tgggctgccg ggacctcact ttcccagggc   1260

ctcacctacc tagggtctca ctagtcgggg gatttaccta cctggggcct cggctgcctg   1320

gggcctcggc tgcctggggt ctcacctgcc tggggcctca cctgctggag tctttggtgg   1380

ccaggcatgt gacttacctg ggatttcact tgccgggctt cactgccagg agcctcccct   1440

gctggggacc ttgccagctg gggctgggga tggtgcctac tggggacctt gctttctgga   1500

ggctgcacct actgaggatc tcggctgttg gggactttac ctgctgggac ctgctcccag   1560

agaccttgcc acactgaatg tcacctgcta ggagcctcac ccgctgggag gcacagggcc   1620

caagggagct ggatgtgttg cccaaggtgt gcagggcagg tcagggaagg gcagggtccc   1680

ctaaggagga gggcgaaggg tatgtgtgtg accatcagca gtggtgtgca catggctggg   1740

ggacactcgg tttgaccgcc agcggatggg tgtcacaaat gcatcactat gggtgtgacc   1800

tcggcgtgac tctgatagtg cctgtggatg tgttgcgatg cctcaccctg gagggcactg   1860

ggccctgaga acgggtgccc ttgaggccct gcccccgggc gatggtgcag gctggtttgc   1920

ttgtggtttt attgctgttg ttaaccaccc atgaggggtg caaacagata atgctgttaa   1980

cattttca                                                            1988


<210>  3390
<211>  85
<212>  PRT
<213>  Homo sapiens

<400>  3390


Met Asp His Thr Ser Tyr Ser Asp Pro Trp Ile Pro Trp Ala Gln Pro 
1               5                   10                  15      


Ser His Ser Gly Cys Gly Ala Ala Val Trp Pro Gly Cys Cys Phe Ser 
            20                  25                  30          


Cys Trp Trp Leu Cys Val Ser Ser Pro Thr Cys Val Cys Pro Glu Thr 
        35                  40                  45              


Met Pro Leu Asp Pro Leu Gly Gln Gly Leu Trp Gln Trp Asn Leu Ser 
    50                  55                  60                  


Pro Gly Leu Pro Met Gly Pro Ala Ala Arg Thr Ala Trp Arg Pro Leu 
65                  70                  75                  80  


Pro Thr Pro Pro Tyr 
                85  

<210>  3391
<211>  2672
<212>  DNA
<213>  Homo sapiens

<400>  3391
ctcccctagt agatagtccc cgcctctagt agtccctaac ctaggactcc ctgagctggg     60

actagcgaaa tctgtctgca ctgatcgcag tcgtcctcag tttcaccctc taggaatcgg    120

cctggggatg cacgtgctac tctcttcctc caggccggtc cccggcgcgt gcgcgcgatc    180

catgtccatg tccgcgccta tcaataaagt tgctcacttg ttgccggccc gctagcccga    240

aaggttgcgc gcgcagcccg agaagtctcg cgatagccag ccgcggctgc ccttgcgctt    300

cccgagctgg cggggtccgt ggtgcgggat cgagattgcg ggctatggcg ccgaaggttt    360

ttcgtcagta ctgggatatc cccgatggca ccgattgcca ccgcaaagcc tacagcacca    420

ccagtattgc cagcgtcgct ggcctgaccg ccgctgccta cagagtcaca ctcaatcctc    480

cgggcacctt ccttgaagga gtggctaagg ttggacaata cacgttcact gcagctgctg    540

tcggggccgt gtttggcctc accacctgca tcagcgccca tgtccgcgag aagcccgacg    600

accccctgaa ctacttcctc ggtggctgcg ccggaggcct gactctggga gcacgcaaga    660

caggatctca ctgtgttgtg caggctggtc tcaaactcct ggcctcgagc agtcctcaca    720

cctcagcctc ccagagtgct gggattatag gcatgagcca ctgtgtacag agattctggg    780

tcccttcttc cagcgcctgc ctcgaagtcc tctctggaga gagcacagat gtccacgcgt    840

gttccagcac aaggggggca tgcaacagct cagggtcacg tccacttccg gagctgggtg    900

cccgggcctc gggctccctg agaaagggcg gacacaccca ccccgcaccc agaggggcag    960

gggccctgac acctgtccaa gccctaatag agtcattgtt aaacactctg ggttcgaacc   1020

ccagaacttg attctttcct tgttctgtcc tcagaggacg gcagcaccca ggcctcagct   1080

ttcccacctg gtaaatggga ataagggccc ctcagagatg ccccacaaag aaagacgatt   1140

ccacctccct gcaggcatcc catccactca cgggcatcgc atccactcga gggcaccggc   1200

ctctgtctct actgcggccg gcagggggca gcgcccacca cagcacggcc tgctgggcag   1260

tgtggacccg ggcggtcatc cccaggcccc cagccccgcg gtgaccacag gcgtcagatt   1320

ccatcccttc ctccgcactc caggccttgt ctgtccctca tcccccttcc ttcccatgca   1380

tcctgcccac cgcagccggg aagtgatggc ttctaggaat gggcaataca gccccaaacc   1440

tccagccaag gacaccgaag gctggacagg aggaaagact agtccacgtc cccacgacgg   1500

tcaccctcag ccctgcacca tggccgcttc tgggactggt tccacgcagg cctccgcccc   1560

ctgcaagccc ttccccggcc ctccaggccc gtgtgcggcc caaaccctgt accagatctc   1620

ttagccctct tccacggatg cgcgcgctga ggcccaccct gggtagtgga gcttgaaatt   1680

taaaggccgc acgccccttc gcacctccca gccccaggtg cctccctgtg ttcaagggag   1740

ccgacggctc agaccaggag ctgtgctcgc cgcccaccca gcccattccg ggctagccgc   1800

cagggttggc gcaggcctgc caggcgcccc cacctcgcct gcaggacggg ccccccagaa   1860

tggaacacga gggggtggtc tcttgctggg ctccagggaa ccccaaagcc gaggcccccc   1920

ggcccataaa catttactag gttgtggagg gctgacgtca ctcccacccc acacacaaga   1980

gggcccccgt ctggaacatc ggtcccagca ggctccctga ggggctgtgg gggacccttc   2040

ctgagtttac cttgaacttc atggagccct tcccagcccc aggcagtcag ggctggaact   2100

gaggaggggc agagcctccc tggggagcta ggagggcttc ctagaggagg aggcggcaca   2160

gcagagaggg cccaaggatg aagaggcttt tccatgtgta cccagcggga ggctggtcca   2220

ggcagagcac acagcaacag cagaggcctg ctgtgaggga gagcagtggg cgatcagggg   2280

cctcctggtc caggagaggt gcctgggggc tgcagggcac acacttgctt cccgagaatc   2340

catccctgga gacacatccc cagcagagac aaggctccaa gaacaccggc ctggccctgc   2400

gccgtggctc aggcctgtaa tcccagtact ttgggaggcc gaggctgggg gatcacttga   2460

ggtcaggagt ttcagaccac cctggccaac acagtgaaac cctgtctcta ctatacaaaa   2520

ataagccagg tgtggtggca ggcacctgta atcccagcta cttgggaggc tgaggcatga   2580

gaatcccttg aacctgggag gtggaggttg cagtgagccg agatcatgtc actgtactcc   2640

agcctgggag acagtgagcg agactttgta tc                                 2672


<210>  3392
<211>  228
<212>  PRT
<213>  Homo sapiens

<400>  3392


Met Ala Pro Lys Val Phe Arg Gln Tyr Trp Asp Ile Pro Asp Gly Thr 
1               5                   10                  15      


Asp Cys His Arg Lys Ala Tyr Ser Thr Thr Ser Ile Ala Ser Val Ala 
            20                  25                  30          


Gly Leu Thr Ala Ala Ala Tyr Arg Val Thr Leu Asn Pro Pro Gly Thr 
        35                  40                  45              


Phe Leu Glu Gly Val Ala Lys Val Gly Gln Tyr Thr Phe Thr Ala Ala 
    50                  55                  60                  


Ala Val Gly Ala Val Phe Gly Leu Thr Thr Cys Ile Ser Ala His Val 
65                  70                  75                  80  


Arg Glu Lys Pro Asp Asp Pro Leu Asn Tyr Phe Leu Gly Gly Cys Ala 
                85                  90                  95      


Gly Gly Leu Thr Leu Gly Ala Arg Lys Thr Gly Ser His Cys Val Val 
            100                 105                 110         


Gln Ala Gly Leu Lys Leu Leu Ala Ser Ser Ser Pro His Thr Ser Ala 
        115                 120                 125             


Ser Gln Ser Ala Gly Ile Ile Gly Met Ser His Cys Val Gln Arg Phe 
    130                 135                 140                 


Trp Val Pro Ser Ser Ser Ala Cys Leu Glu Val Leu Ser Gly Glu Ser 
145                 150                 155                 160 


Thr Asp Val His Ala Cys Ser Ser Thr Arg Gly Ala Cys Asn Ser Ser 
                165                 170                 175     


Gly Ser Arg Pro Leu Pro Glu Leu Gly Ala Arg Ala Ser Gly Ser Leu 
            180                 185                 190         


Arg Lys Gly Gly His Thr His Pro Ala Pro Arg Gly Ala Gly Ala Leu 
        195                 200                 205             


Thr Pro Val Gln Ala Leu Ile Glu Ser Leu Leu Asn Thr Leu Gly Ser 
    210                 215                 220                 


Asn Pro Arg Thr 
225             

<210>  3393
<211>  923
<212>  DNA
<213>  Homo sapiens

<400>  3393
acctaggact ccctgagctg ggactagcga aatctgtctg cactgatcgc agtcgtcctc     60

agtttcaccc tctaggaatc ggcctgggga tgcacgtgct actctcttcc tccaggccgg    120

tccccggcgc gtgcgcgcga tccatgtcca tgtccgcgcc tatcaataaa gttgctcact    180

tgttgccggc ccgctagccc gaaaggttgc gcgcgcagcc cgagaagtct cgcgatagcc    240

agccgcggct gcccttgcgc ttcccgagct ggcggggtcc gtggtgcggg atcgagattg    300

cgggctatgg cgccgaaggt ttttcgtcag tactgggata tccccgatgg caccgattgc    360

caccgcaaag cctacagcac caccagtatt gccagcgtcg ctggtaggga ctgaaggttg    420

gagaagcata ttaactgctc cagggtcatt tgaagctggg ctgcaagtcc aggtcggctg    480

acctgctcct aggggtctct gaagcaagga atgttcccat caggcctgac cgccgctgcc    540

tacagagtca cactcaatcc tccgggcacc ttccttgaag gagtggctaa ggttggacaa    600

tacacgttca ctgcagctgc tgtcggggcc gtgtttggcc tcaccacctg catcagcgcc    660

catgtccgcg agaagcccga cgaccccctg aactacttcc tcggtggctg cgccggaggc    720

ctgactctgg gagcacgcac gcacaactac gggattggcg ccgccgcctg cgtgtacttt    780

ggcatagcgg cctccctggt caagatgggc cggctggagg gctgggaggt gtttgcaaaa    840

cccaaggtgt gagccctgtg cctgccggga cctccagcct gcagaatgcg tccagaaata    900

aattctgtgt ctgtgtgtgt gtc                                            923


<210>  3394
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  3394


Met Phe Pro Ser Gly Leu Thr Ala Ala Ala Tyr Arg Val Thr Leu Asn 
1               5                   10                  15      


Pro Pro Gly Thr Phe Leu Glu Gly Val Ala Lys Val Gly Gln Tyr Thr 
            20                  25                  30          


Phe Thr Ala Ala Ala Val Gly Ala Val Phe Gly Leu Thr Thr Cys Ile 
        35                  40                  45              


Ser Ala His Val Arg Glu Lys Pro Asp Asp Pro Leu Asn Tyr Phe Leu 
    50                  55                  60                  


Gly Gly Cys Ala Gly Gly Leu Thr Leu Gly Ala Arg Thr His Asn Tyr 
65                  70                  75                  80  


Gly Ile Gly Ala Ala Ala Cys Val Tyr Phe Gly Ile Ala Ala Ser Leu 
                85                  90                  95      


Val Lys Met Gly Arg Leu Glu Gly Trp Glu Val Phe Ala Lys Pro Lys 
            100                 105                 110         


Val 
    

<210>  3395
<211>  841
<212>  DNA
<213>  Homo sapiens

<400>  3395
ctcccctagt agatagtccc cgcctctagt agtccctaac ctaggactcc ctgagctggg     60

actagcgaaa tctgtctgca ctgatcgcag tcgtcctcag tttcaccctc taggaatcgg    120

cctggggatg cacgtgctac tctcttcctc caggccggtc cccggcgcgt gcgcgcgatc    180

catgtccatg tccgcgccta tcaataaagt tgctcacttg ttgccggccc gctagcccga    240

aaggttgcgc gcgcagcccg agaagtctcg cgatagccag ccgcggctgc ccttgcgctt    300

cccgagctgg cggggtccgt ggtgcgggat cgagattgcg ggctatggcg ccgaaggttt    360

ttcgtcagta ctgggatatc cccgatggca ccgattgcca ccgcaaagcc tacagcacca    420

ccagtattgc cagcgtcgct ggcctgaccg ccgctgccta cagagtcaca ctcaatcctc    480

cgggcacctt ccttgaagga gtggctaagg ttggacaata cacgttcact gcagctgctg    540

tcggggccgt gtttggcctc accacctgca tcagcgccca tgtccgcgag aagcccgacg    600

accccctgaa ctacttcctc ggtggctgcg ccggaggcct gactctggga gcacgcacgc    660

acaactacgg gattggcgcc gccgcctgcg tgtactttgg catagcggcc tccctggtca    720

agatgggccg gctggagggc tgggaggtgt ttgcaaaacc caaggtgtga gccctgtgcc    780

tgccgggacc tccagcctgc agaatgcgtc cagaaataaa ttctgtgtct gtgtgtgtgt    840

c                                                                    841


<210>  3396
<211>  141
<212>  PRT
<213>  Homo sapiens

<400>  3396


Met Ala Pro Lys Val Phe Arg Gln Tyr Trp Asp Ile Pro Asp Gly Thr 
1               5                   10                  15      


Asp Cys His Arg Lys Ala Tyr Ser Thr Thr Ser Ile Ala Ser Val Ala 
            20                  25                  30          


Gly Leu Thr Ala Ala Ala Tyr Arg Val Thr Leu Asn Pro Pro Gly Thr 
        35                  40                  45              


Phe Leu Glu Gly Val Ala Lys Val Gly Gln Tyr Thr Phe Thr Ala Ala 
    50                  55                  60                  


Ala Val Gly Ala Val Phe Gly Leu Thr Thr Cys Ile Ser Ala His Val 
65                  70                  75                  80  


Arg Glu Lys Pro Asp Asp Pro Leu Asn Tyr Phe Leu Gly Gly Cys Ala 
                85                  90                  95      


Gly Gly Leu Thr Leu Gly Ala Arg Thr His Asn Tyr Gly Ile Gly Ala 
            100                 105                 110         


Ala Ala Cys Val Tyr Phe Gly Ile Ala Ala Ser Leu Val Lys Met Gly 
        115                 120                 125             


Arg Leu Glu Gly Trp Glu Val Phe Ala Lys Pro Lys Val 
    130                 135                 140     

<210>  3397
<211>  404
<212>  DNA
<213>  Homo sapiens

<400>  3397
actcgtggca tctctctcca tccagacact ggcagtgagc gcccaagagg ctcctgctgt     60

gcccgtctcg aggcccttgc tcttcccgtc taccccgcag ctgctgtcgg ggccgtgttt    120

ggcctcacca cctgcatcag cgcccatgtc cgcgagaagc ccgacgaccc cctgaactac    180

ttcctcggtg gctgcgccgg aggcctgact ctgggagcac gcacgcacaa ctacgggatt    240

ggcgccgccg cctgcgtgta ctttggcata gcggcctccc tggtcaagat gggccggctg    300

gagggctggg aggtgtttgc aaaacccaag gtgtgagccc tgtgcctgcc gggacctcca    360

gcctgcagaa tgcgtccaga aataaattct gtgtctgtgt gtgt                     404


<210>  3398
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  3398


Ala Pro Lys Arg Leu Leu Leu Cys Pro Ser Arg Gly Pro Cys Ser Ser 
1               5                   10                  15      


Arg Leu Pro Arg Ser Cys Cys Arg Gly Arg Val Trp Pro His His Leu 
            20                  25                  30          


His Gln Arg Pro Cys Pro Arg Glu Ala Arg Arg Pro Pro Glu Leu Leu 
        35                  40                  45              


Pro Arg Trp Leu Arg Arg Arg Pro Asp Ser Gly Ser Thr His Ala Gln 
    50                  55                  60                  


Leu Arg Asp Trp Arg Arg Arg Leu Arg Val Leu Trp His Ser Gly Leu 
65                  70                  75                  80  


Pro Gly Gln Asp Gly Pro Ala Gly Gly Leu Gly Gly Val Cys Lys Thr 
                85                  90                  95      


Gln Gly Val Ser Pro Val Pro Ala Gly Thr Ser Ser Leu Gln Asn Ala 
            100                 105                 110         


Ser Arg Asn Lys Phe Cys Val Cys Val 
        115                 120     

<210>  3399
<211>  2398
<212>  DNA
<213>  Homo sapiens

<400>  3399
acctaggact ccctgagctg ggactagcga aatctgtctg cactgatcgc agtcgtcctc     60

agtttcaccc tctaggaatc ggcctgggga tgcacgtgct actctcttcc tccaggccgg    120

tccccggcgc gtgcgcgcga tccatgtcca tgtccgcgcc tatcaataaa gttgctcact    180

tgttgccggc ccgctagccc gaaaggttgc gcgcgcagcc cgagaagtct cgcgatagcc    240

agccgcggct gcccttgcgc ttcccgagct ggcggggtcc gtggtgcggg atcgagattg    300

cgggctatgg cgccgaaggt ttttcgtcag tactgggata tccccgatgg caccgattgc    360

caccgcaaag cctacagcac caccagtatt gccagcgtcg ctggcctgac cgccgctgcc    420

tacagagtca cactcaatcc tccgggcacc ttccttgaag gagtggctaa ggttggacaa    480

tacacgttca ctgcagctgc tgtcggggcc gtgtttggcc tcaccacctg catcagcgcc    540

catgtccgcg agaagcccga cgaccccctg aactacttcc tcggtggctg cgccggaggc    600

ctgactctgg gagcacgcag tgagtggccc cctccccacc cccaccctcc tcccagcctg    660

gcagaatgac ccctgacctc tgctcatcct ccaccctctc tgttccatcc cggacaagaa    720

gtaaagcagc cttcttgaac accagccatt tcagtcatag cgacagctgc tgctgctgct    780

taagcaccta ctgtggccct ccctgacctg ccctgtcccc tccccaccct cccctcctca    840

ctctgctcca gccacacggg cctcctcact gctcctccca catgccaggt acagtcctgc    900

cccagggcct ttgcatgggc agtgcactgc gtggaatgct gttcccctca ctgtcctgac    960

caccctgtgt acaagccagc atccccgccg ccctcgctct gtgccgcctt ccttctgtgt   1020

gccttgtcag aggacacagg tcaccaaggt caccccctgt ctctgccact ggcctgtgag   1080

tcagagagga ggatggatgg agtctcgccc tgccatctct ctccctgcac ctggagccct   1140

gcaggggagc tgcccccgca accttcactt tacagaaaag ggtattaggg ctcagggagg   1200

gaattaagtg gcccgaggtc acctggagga gcaagtggcc ttctttgcag ccatcagagg   1260

gtgcagccct ggtggagaag gccacgcttg gcacagggga gcccgtctgg agcatgagcc   1320

agacatcact cctgccctcc catgggcccg ggctcagcgt cagtgcccgc ctgtgcccct   1380

ggcctacccc cagcccgcca aggctcgggc cctcagggcc agcgggagga gtgaacgagc   1440

cctcttgcag ctcagccgct ctggcctggc atgttgggag tgatgaatgg caggttccag   1500

gcaggcagag agggagggtg cgagggcagg gcgtacgccg tcactgctgt ctctgcgtca   1560

agaccttggg gaggccttgt ccctccccag ctcccactgg aactggtcag aggttgcagg   1620

tgggttgagg tcttgactgt agcccagctc aggctggaac tgctccctgt ccccaagcca   1680

gcctccctgt ctctcttcaa agagtgtgag tccctttagg tcctggtgtg tggggacaca   1740

cctccttcct cctctggccc ggaggcttcg gagcaggaga gcctggagaa gtgggggcac   1800

tgtcggggct cctcggtaca cagaccacgg gacagatgcg tggcctggcc ctggcatcca   1860

tgggcaaagg agagactgag acacaccgat gtgtcaccat ggcccggtgc ccagccttgc   1920

cccagcccca gctgggggca gcacggtgtc ctcgcagggg gaagtcagtg tggggcggga   1980

tgaggaccca cagcctgggt tcctgctggg aagcaacctg gactccggcc tccctctgtg   2040

catcagtttc cacatctcca gagtctaggg ccctcttcct gagtgactta atccctgaag   2100

agagtgtcct gtcaggggtc tcagtctggc tcccagggtg ggcaccggcc agggcgtgga   2160

gcgtcttggt ccggccgagc cccacccggg cctgacatca cctccccact cccacagcgc   2220

acaactacgg gattggcgcc gccgcctgcg tgtactttgg catagcggcc tccctggtca   2280

agatgggccg gctggagggc tgggaggtgt ttgcaaaacc caaggtgtga gccctgtgcc   2340

tgccgggacc tccagcctgc agaatgcgtc cagaaataaa ttctgtgtct gtgtgtgt     2398


<210>  3400
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  3400


Met Ala Pro Lys Val Phe Arg Gln Tyr Trp Asp Ile Pro Asp Gly Thr 
1               5                   10                  15      


Asp Cys His Arg Lys Ala Tyr Ser Thr Thr Ser Ile Ala Ser Val Ala 
            20                  25                  30          


Gly Leu Thr Ala Ala Ala Tyr Arg Val Thr Leu Asn Pro Pro Gly Thr 
        35                  40                  45              


Phe Leu Glu Gly Val Ala Lys Val Gly Gln Tyr Thr Phe Thr Ala Ala 
    50                  55                  60                  


Ala Val Gly Ala Val Phe Gly Leu Thr Thr Cys Ile Ser Ala His Val 
65                  70                  75                  80  


Arg Glu Lys Pro Asp Asp Pro Leu Asn Tyr Phe Leu Gly Gly Cys Ala 
                85                  90                  95      


Gly Gly Leu Thr Leu Gly Ala Arg Ser Glu Trp Pro Pro Pro His Pro 
            100                 105                 110         


His Pro Pro Pro Ser Leu Ala Glu 
        115                 120 

<210>  3401
<211>  2091
<212>  DNA
<213>  Homo sapiens

<400>  3401
acctaggact ccctgagctg ggactagcga aatctgtctg cactgatcgc agtcgtcctc     60

agtttcaccc tctaggaatc ggcctgggga tgcacgtgct actctcttcc tccaggccgg    120

tccccggcgc gtgcgcgcga tccatgtcca tgtccgcgcc tatcaataaa gttgctcact    180

tgttgccggc ccgctagccc gaaaggttgc gcgcgcagcc cgagaagtct cgcgatagcc    240

agccgcggct gcccttgcgc ttcccgagct ggcggggtcc gtggtgcggg atcgagattg    300

cgggctatgg cgccgaaggt ttttcgtcag tactgggata tccccgatgg caccgattgc    360

caccgcaaag cctacagcac caccagtatt gccagcgtcg ctggcctgac cgccgctgcc    420

tacagagtca cactcaatcc tccgggcacc ttccttgaag gagtggctaa ggttggacaa    480

tacacgttca ctgcagctgc tgtcggggcc gtgtttggcc tcaccacctg catcagcgcc    540

catgtccgcg agaagcccga cgaccccctg aactacttcc tcggtggctg cgccggaggc    600

ctgactctgg gagcacgcag tgagtggccc cctccccacc cccaccctcc tcccagcctg    660

gcagaatgac ccctgacctc tgctcatcct ccaccctctc tgttccatcc cggacaagaa    720

gtaaagcagc cttcttgaac accagtcact gtcctgacca ccctgtgtac aagccagcat    780

ccccgccgcc ctcgctctgt gccgccttcc ttctgtgtgc cttgtcagag gacacaggtc    840

accaaggtca ccccctgtct ctgccactgg cctgtgagtc agagaggagg atggatggag    900

tctcgccctg ccatctctct ccctgcacct ggcttctttg cagccatcag agggtgcagc    960

cctggtggag aaggccacgc ttggcacagg ggagcccgtc tggagcatga gccagacatc   1020

actcctgccc tcccatgggc ccgggctcag cgtcagtgcc cgcctgtgcc cctggcctac   1080

ccccagcccg ccaaggctcg ggccctcagg gccagcggga ggagtgaacg agccctcttg   1140

cagctcagcc gctctggcct ggcatgttgg gagtgatgaa tggcaggttc caggcaggca   1200

gagagggagg gtgcgagggc agggcgtacg ccgtcactgc tgtctctgcg tcaagacctt   1260

ggggaggcct tgtccctccc cagctcccac tggaactggt cagaggttgc aggtgggttg   1320

aggtcttgac tgtagcccag ctcaggctgg aactgctccc tgtccccaag ccagcctccc   1380

tgtctctctt caaagagtgt gagtcccttt aggtcctggt gtgtggggac acacctcctt   1440

cctcctctgg cccggaggct tcggagcagg agagcctgga gaagtggggg cactgtcggg   1500

gctcctcggt acacagacca cgggacagat gcgtggcctg gccctggcat ccatgggcaa   1560

aggagagact gagacacacc gatgtgtcac catggcccgg tgcccagcct tgccccagcc   1620

ccagctgggg gcagcacggt gtcctcgcag ggggaagtca gtgtggggcg ggatgaggac   1680

ccacagcctg ggttcctgct gggaagcaac ctggactccg gcctccctct gtgcatcagt   1740

ttccacatct ccagagtcta gggccctctt cctgagtgac ttaatccctg aagagagtgt   1800

cctgtcaggg gtctcagtct ggctcccagg gtgggcaccg gccagggcgt ggagcgtctt   1860

ggtccggccg agccccaccc gggcctgaca tcacctcccc actcccacag cgcacaacta   1920

cgggattggc gccgccgcct gcgtgtactt tggcatagcg gcctccctgg tcaagatggg   1980

ccggctggag ggctgggagg tgtttgcaaa acccaaggtg tgagccctgt gcctgccggg   2040

acctccagcc tgcagaatgc gtccagaaat aaattctgtg tctgtgtgtg t            2091


<210>  3402
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  3402


Met Ala Pro Lys Val Phe Arg Gln Tyr Trp Asp Ile Pro Asp Gly Thr 
1               5                   10                  15      


Asp Cys His Arg Lys Ala Tyr Ser Thr Thr Ser Ile Ala Ser Val Ala 
            20                  25                  30          


Gly Leu Thr Ala Ala Ala Tyr Arg Val Thr Leu Asn Pro Pro Gly Thr 
        35                  40                  45              


Phe Leu Glu Gly Val Ala Lys Val Gly Gln Tyr Thr Phe Thr Ala Ala 
    50                  55                  60                  


Ala Val Gly Ala Val Phe Gly Leu Thr Thr Cys Ile Ser Ala His Val 
65                  70                  75                  80  


Arg Glu Lys Pro Asp Asp Pro Leu Asn Tyr Phe Leu Gly Gly Cys Ala 
                85                  90                  95      


Gly Gly Leu Thr Leu Gly Ala Arg Ser Glu Trp Pro Pro Pro His Pro 
            100                 105                 110         


His Pro Pro Pro Ser Leu Ala Glu 
        115                 120 

<210>  3403
<211>  591
<212>  DNA
<213>  Homo sapiens

<400>  3403
acctaggact ccctgagctg ggactagcga aatctgtctg cactgatcgc agtcgtcctc     60

agtttcaccc tctaggaatc ggcctgggga tgcacgtgct actctcttcc tccaggccgg    120

tccccggcgc gtgcgcgcga tccatgtcca tgtccgcgcc tatcaataaa gttgctcact    180

tgttgccggc ccgctagccc gaaaggttgc gcgcgcagcc cgagaagtct cgcgatagcc    240

agccgcggct gcccttgcgc ttcccgagct ggcggggtcc gtggtgcggg atcgagattg    300

cgggctatgg cgccgaaggt ttttcgtcag tactgggata tccccgatgg caccgattgc    360

caccgcaaag cctacagcac caccagtatt gccagcgtcg ctggcctgac cgccgctgcc    420

tacagagtca cactcaatcc tccgggcacc ttccttgaag gagtggctaa ggttggacaa    480

tacacgttca ctgcagcgcc catgtccgcg agaagcccga cgaccccctg aactacttcc    540

tcggtggctg cgccggaggc ctgactctgg gagcacgcag tgagtggccc c             591


<210>  3404
<211>  74
<212>  PRT
<213>  Homo sapiens

<400>  3404


Met Ala Pro Lys Val Phe Arg Gln Tyr Trp Asp Ile Pro Asp Gly Thr 
1               5                   10                  15      


Asp Cys His Arg Lys Ala Tyr Ser Thr Thr Ser Ile Ala Ser Val Ala 
            20                  25                  30          


Gly Leu Thr Ala Ala Ala Tyr Arg Val Thr Leu Asn Pro Pro Gly Thr 
        35                  40                  45              


Phe Leu Glu Gly Val Ala Lys Val Gly Gln Tyr Thr Phe Thr Ala Ala 
    50                  55                  60                  


Pro Met Ser Ala Arg Ser Pro Thr Thr Pro 
65                  70                  

<210>  3405
<211>  597
<212>  DNA
<213>  Homo sapiens

<400>  3405
cctaggactc cctgagctgg gactagcgaa atctgtctgc actgatcgca gtcgtcctca     60

gtttcaccct ctaggaatcg gcctggggat gcacgtgcta ctctcttcct ccaggccggt    120

ccccggcgcg tgcgcgcgat ccatgtccat gtccgcgcct atcaataaag ttgctcactt    180

gttgccggcc cgctagcccg aaaggttgcg cgcgcagccc gagaagtctc gcgatagcca    240

gccgcggctg cccttgcgct tcccgagctg gcggggtccg tggtgcggga tcgagattgc    300

gggctatggc gccgaaggtt tttcgtcagt actgggatat ccccgatggc accgattgcc    360

accgcaaagc ctacagcacc accagtattg ccagcgtcgc tggtagggac tgaaggttgg    420

agaagcatat taactgctcc agggtcattt gaagctgggc tgcaagtcca ggcctgaccg    480

ccgctgccta cagagtcaca ctcaatcctc cgggcacctt ccttgaagga gtggctaagg    540

ttggacaata cacgttcact gcagcccgtg tccacagtgc tggccatccg gagaaag       597


<210>  3406
<211>  43
<212>  PRT
<213>  Homo sapiens

<400>  3406


Met Ala Pro Ile Ala Thr Ala Lys Pro Thr Ala Pro Pro Val Leu Pro 
1               5                   10                  15      


Ala Ser Leu Val Gly Thr Glu Gly Trp Arg Ser Ile Leu Thr Ala Pro 
            20                  25                  30          


Gly Ser Phe Glu Ala Gly Leu Gln Val Gln Ala 
        35                  40              

<210>  3407
<211>  516
<212>  DNA
<213>  Homo sapiens

<400>  3407
ctgggattaa aggcctgagc aaccatgccc ggacttgaag attcttaatg ggaggggact     60

gccagccctg cctgggacct gaaaagtcct gatccagggc tgggccagcc atgacagtct    120

tataaccctc tcatctcaag agggaaccac cgacaagact cagtgacgcc cccagaactg    180

tcaccgaggg actcctgggc ggaacctcct tacaccaccc ccacatgcca gctgtcctga    240

ccaagggacc cctagctcat ggagcacacc tgacacgatc ctatcccctg ggtggccccc    300

ttcagccctt tctcttgaag accctcgata aggacctgat gggaacattc cttgcttcag    360

agacccctag gagcaggtca gccgacctgg acttgcagcc cagcttcaaa tgaccctgga    420

gcagttaata tgcttctcca accttcagtc cctacctgta agaaatggag acacaataac    480

gtctgtctta ctattaataa atatgcaaaa tatggg                              516


<210>  3408
<211>  62
<212>  PRT
<213>  Homo sapiens

<400>  3408


Met Pro Ala Val Leu Thr Lys Gly Pro Leu Ala His Gly Ala His Leu 
1               5                   10                  15      


Thr Arg Ser Tyr Pro Leu Gly Gly Pro Leu Gln Pro Phe Leu Leu Lys 
            20                  25                  30          


Thr Leu Asp Lys Asp Leu Met Gly Thr Phe Leu Ala Ser Glu Thr Pro 
        35                  40                  45              


Arg Ser Arg Ser Ala Asp Leu Asp Leu Gln Pro Ser Phe Lys 
    50                  55                  60          

<210>  3409
<211>  635
<212>  DNA
<213>  Homo sapiens

<400>  3409
ctcccctagt agatagtccc cgcctctagt agtccctaac ctaggactcc ctgagctggg     60

actagcgaaa tctgtctgca ctgatcgcag tcgtcctcag tttcaccctc taggaatcgg    120

cctggggatg cacgtgctac tctcttcctc caggccggtc cccggcgcgt gcgcgcgatc    180

catgtccatg tccgcgccta tcaataaagt tgctcacttg ttgccggccc gctagcccga    240

aaggttgcgc gcgcagcccg agaagtctcg cgatagccag ccgcggctgc ccttgcgctt    300

cccgagctgg cggggtccgt ggtgcgggat cgagattgcg ggctatggcg ccgaaggttt    360

ttcgtcagta ctgggatatc cccgatggca ccgattgcca ccgcaaagcc tacagcacca    420

ccagtattgc cagcgtcgct gccacaggtt gggactcatc aggtcccaga tggagctgga    480

agtcctcttc cctctgatga agaatcttta caaactgggc caggcgcggt ggctcacacc    540

tgtaatccgg cgctcaggag gccaaagtgg gaggatcgct tgaggccagg agttccagac    600

cagcctgggc aaaatagcaa gatccccatc tctgc                               635


<210>  3410
<211>  82
<212>  PRT
<213>  Homo sapiens

<400>  3410


Met Ala Pro Ile Ala Thr Ala Lys Pro Thr Ala Pro Pro Val Leu Pro 
1               5                   10                  15      


Ala Ser Leu Pro Gln Val Gly Thr His Gln Val Pro Asp Gly Ala Gly 
            20                  25                  30          


Ser Pro Leu Pro Ser Asp Glu Glu Ser Leu Gln Thr Gly Pro Gly Ala 
        35                  40                  45              


Val Ala His Thr Cys Asn Pro Ala Leu Arg Arg Pro Lys Trp Glu Asp 
    50                  55                  60                  


Arg Leu Arg Pro Gly Val Pro Asp Gln Pro Gly Gln Asn Ser Lys Ile 
65                  70                  75                  80  


Pro Ile 
        

<210>  3411
<211>  1476
<212>  DNA
<213>  Homo sapiens

<400>  3411
agttccgggc cgcctggggg cgtggccggg cctgtacagc agcctgggcc atgtcggcgc     60

cgccggccct gcagatccgg gaggcaaacg cacacctggc agccgtgcac cggcgcgcag    120

cggagctgga ggcgcggctg gacgcggcgg agcgcacggt gcacgcccaa gccgagcgcc    180

tggccctcca cgaccagcag ctgcgcgccg ccctagacga actgggtcgc gccaaggacc    240

gaggcacctt ccactagcaa cagtctcccc aggcacaaca cagctaacac aaggccccgc    300

aggcaggact ctgggacaga cgcaggccag ctgcccagag cccagaccaa gcatggacgc    360

cgtggatgcc accatggaga aactccgggc acagtgcctg tcccgcgggg cctcgggcat    420

ccagggcctg gccaggtttt tccgccaact agaccgggac gggagcagat ccctggacgc    480

tgatgagttc cggcagggtc tggccaaact cgggctggtg ctggaccagg cggaggcaga    540

gggtgtgtgc aggaagtggg accgcaatgg cagcgggacg ctggatctgg aggagttcct    600

tcgggcgctg cggcccccca tgtcccaggc ccgggaggct gtcatcgcag ctgcatttgc    660

caagctggac cgcagtgggg acggcgtcgt gacggtggac gacctccgcg gggtgtacag    720

tggccgtgcc caccccaagg tgcgcagtgg ggagtggacc gaggacgagg tgctgcgccg    780

cttcctggac aacttcgact cctctgagaa ggacgggcag gtcacactgg cggaattcca    840

ggactactac agcggcgtga gtgcctccat gaacacggat gaggagttcg tggccatgat    900

gaccagtgcc tggcagctgt gagcagctcc ggctcagccc tgctgccctg gcctgtcact    960

ccccacccct gccggagacc tcccttccct gggccccttc tctcctgggc agccacacca   1020

cagagcgggg aggggcaggt gggggaatgg aggctgcagg actggctaga ccaggtccct   1080

gccggtccac caggcggagg tgggacaaag gtcctaacag gagtcactgg ctcaggaccc   1140

cagggagaaa cgctctcccc acccacgcca tgctgaccag agatcttgca gcccctgtgg   1200

atgcccccgc cgaggtcccc cgatccccgc acccggactg ctgctccctg cccctccctt   1260

gcgggtcccc caggaagcca ggtgacccca ggtgggaggc tgtgtgtgga ggccatcctg   1320

gaaggaagtt tagacctgcc caggtgtgga gcgaggggca caggggcatc ctaacctcag   1380

aaactgaaat aaagcctttg aaaaaaaaat ctgtaaaaca tcaaccccca atcagaagat   1440

ggcaaatggg gaataaaaat agcaggtaac atgtcc                             1476


<210>  3412
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  3412


Met Asp Ala Val Asp Ala Thr Met Glu Lys Leu Arg Ala Gln Cys Leu 
1               5                   10                  15      


Ser Arg Gly Ala Ser Gly Ile Gln Gly Leu Ala Arg Phe Phe Arg Gln 
            20                  25                  30          


Leu Asp Arg Asp Gly Ser Arg Ser Leu Asp Ala Asp Glu Phe Arg Gln 
        35                  40                  45              


Gly Leu Ala Lys Leu Gly Leu Val Leu Asp Gln Ala Glu Ala Glu Gly 
    50                  55                  60                  


Val Cys Arg Lys Trp Asp Arg Asn Gly Ser Gly Thr Leu Asp Leu Glu 
65                  70                  75                  80  


Glu Phe Leu Arg Ala Leu Arg Pro Pro Met Ser Gln Ala Arg Glu Ala 
                85                  90                  95      


Val Ile Ala Ala Ala Phe Ala Lys Leu Asp Arg Ser Gly Asp Gly Val 
            100                 105                 110         


Val Thr Val Asp Asp Leu Arg Gly Val Tyr Ser Gly Arg Ala His Pro 
        115                 120                 125             


Lys Val Arg Ser Gly Glu Trp Thr Glu Asp Glu Val Leu Arg Arg Phe 
    130                 135                 140                 


Leu Asp Asn Phe Asp Ser Ser Glu Lys Asp Gly Gln Val Thr Leu Ala 
145                 150                 155                 160 


Glu Phe Gln Asp Tyr Tyr Ser Gly Val Ser Ala Ser Met Asn Thr Asp 
                165                 170                 175     


Glu Glu Phe Val Ala Met Met Thr Ser Ala Trp Gln Leu 
            180                 185                 

<210>  3413
<211>  1395
<212>  DNA
<213>  Homo sapiens

<400>  3413
agttccgggc cgcctggggg cgtggccggg cctgtacagc agcctgggcc atgtcggcgc     60

cgccggccct gcagatccgg gaggcaaacg cacacctggc agccgtgcac cggcgcgcag    120

cggagctgga ggcgcggctg gacgcggcgg agcgcacggt gcacgcccaa gccgagcgcc    180

tggccctcca cgaccagcag ctgcgcgccg ccctagacga actgggtcgc gccaaggacc    240

gaggcacctt ccactagcaa cagtctcccc aggcacaaca cagctaacac aaggccccgc    300

aggcaggact ctgggacaga cgcaggccag ctgcccagag cccagaccaa gcatggacgc    360

cgtggatgcc accatggaga aactccgggc acagtgcctg tcccgcgggg cctcgggcat    420

ccagggcctg gccaggtttt tccgccaact agaccgggac gggagcagat ccctggacgc    480

tgatgagttc cggcagggtc tggccaaact cgggctggtg ctggaccagg cggaggcaga    540

gggtgtgtgc aggaagtggg accgcaatgg cagcgggacg ctggatctgg aggagttcct    600

tcgggcgctg cggcccccca tgtcccaggc ccgggaggct gtcatcgcag ctgcatttgc    660

caagctggac cgcagtgggg acggcgtcgt gacggtggac gacctccgcg gggtgtacag    720

tggccgtgcc caccccaagg tcacactggc ggaattccag gactactaca gcggcgtgag    780

tgcctccatg aacacggatg aggagttcgt ggccatgatg accagtgcct ggcagctgtg    840

agcagctccg gctcagccct gctgccctgg cctgtcactc cccacccctg ccggagacct    900

cccttccctg ggccccttct ctcctgggca gccacaccac agagcgggga ggggcaggtg    960

ggggaatgga ggctgcagga ctggctagac caggtccctg ccggtccacc aggcggaggt   1020

gggacaaagg tcctaacagg agtcactggc tcaggacccc agggagaaac gctctcccca   1080

cccacgccat gctgaccaga gatcttgcag cccctgtgga tgcccccgcc gaggtccccc   1140

gatccccgca cccggactgc tgctccctgc ccctcccttg cgggtccccc aggaagccag   1200

gtgaccccag gtgggaggct gtgtgtggag gccatcctgg aaggaagttt agacctgccc   1260

aggtgtggag cgaggggcac aggggcatcc taacctcaga aactgaaata aagcctttga   1320

aaaaaaaatc tgtaaaacat caacccccaa tcagaagatg gcaaatgggg aataaaaata   1380

gcaggtaaca tgtcc                                                    1395


<210>  3414
<211>  162
<212>  PRT
<213>  Homo sapiens

<400>  3414


Met Asp Ala Val Asp Ala Thr Met Glu Lys Leu Arg Ala Gln Cys Leu 
1               5                   10                  15      


Ser Arg Gly Ala Ser Gly Ile Gln Gly Leu Ala Arg Phe Phe Arg Gln 
            20                  25                  30          


Leu Asp Arg Asp Gly Ser Arg Ser Leu Asp Ala Asp Glu Phe Arg Gln 
        35                  40                  45              


Gly Leu Ala Lys Leu Gly Leu Val Leu Asp Gln Ala Glu Ala Glu Gly 
    50                  55                  60                  


Val Cys Arg Lys Trp Asp Arg Asn Gly Ser Gly Thr Leu Asp Leu Glu 
65                  70                  75                  80  


Glu Phe Leu Arg Ala Leu Arg Pro Pro Met Ser Gln Ala Arg Glu Ala 
                85                  90                  95      


Val Ile Ala Ala Ala Phe Ala Lys Leu Asp Arg Ser Gly Asp Gly Val 
            100                 105                 110         


Val Thr Val Asp Asp Leu Arg Gly Val Tyr Ser Gly Arg Ala His Pro 
        115                 120                 125             


Lys Val Thr Leu Ala Glu Phe Gln Asp Tyr Tyr Ser Gly Val Ser Ala 
    130                 135                 140                 


Ser Met Asn Thr Asp Glu Glu Phe Val Ala Met Met Thr Ser Ala Trp 
145                 150                 155                 160 


Gln Leu 
        

<210>  3415
<211>  1722
<212>  DNA
<213>  Homo sapiens

<400>  3415
agttccgggc cgcctggggg cgtggccggg cctgtacagc agcctgggcc atgtcggcgc     60

cgccggccct gcagatccgg gaggcaaacg cacacctggc agccgtgcac cggcgcgcag    120

cggagctgga ggcgcggctg gacgcggcgg agcgcacggt gcacgcccaa gccgagcgcc    180

tggccctcca cgaccagcag ctgcgcgccg ccctagacga actgggtcgc gccaaggacc    240

gaggcacctt ccactagcaa cagtctcccc aggcacaaca cagctaacac aaggccccgc    300

aggcaggact ctgggacaga cgcaggccag ctgcccagag cccagaccaa gcatggacgc    360

cgtggatgcc accatggaga aactccgggc acagtgcctg tcccgcgggg cctcgggcat    420

ccagggcctg gccaggtttt tccgccaact agaccgggac gggagcagat ccctggacgc    480

tgatgagttc cggcagggtc tggccaaact cgggctggtg ctggaccagg cggaggcaga    540

gggtgtgtgc aggaagtggg accgcaatgg cagcgggacg ctggatctgg aggagttcct    600

tcgggcgctg cggcccccca tgtcccaggc ccgggaggct gtcatcgcag ctgcatttgc    660

caagctggac cgcagtgggg acggcgtcgt gacggtggac gacctccgcg gggtgtacag    720

tggccgtgcc caccccaagg tcacactggc ggaattccag gactactaca gcggcgtgag    780

tgcctccatg aacacggatg aggagttcgt ggccatgatg accagtgcct ggcagctgtg    840

agcagctccg gctcagccct gctgccctgg cctgtcactc cccacccctg ccggagacct    900

cccttccctg ggccccttct ctcctgggca gccacaccac agagcgggga ggggcaggtg    960

ggggaatgga ggctgcagga ctggctagac caggtccctg ccggtccacc aggcggaggt   1020

gggacaaagg tcctaacagg agtcactggc tcaggacccc agggagaaac gctctcccca   1080

cccacgccat gctgaccaga gatcttgcag cccctgtgga tgcccccgcc gaggtccccc   1140

gatccccgca cccggactgc tgctccctgc ccctcccttg cgggtccccc aggaagccag   1200

gtgaccccag gtgggaggct gtgtgtggag gccatcctgg aaggaagttt agacctgccc   1260

aggtgtggag cgaggggcac aggggcatcc taacctcaga aactgaaata aagcctttga   1320

aaaaaaaatc tgtaaaacat caacccccaa tcagaagatg gcaaatgggg aataaaaata   1380

gcaggtaaca tgtccagcgg gcccagtatc tacattctgg tgagcggccc gaggctggga   1440

gctctgggcg ggggcagacc ggcggggcct tgcagcaggg gtgggggtaa agtgcgggtg   1500

gtggtggaga gaacagggct gtggctggac cccagcactg gtgacacgct gggtgggagc   1560

atgaggcccc aggctgctgg aggtcctcgc ccggggaggt ggaggccgtt cctggtcagg   1620

ggcttcctga ggcccctggg gcatgcagag gccagggttt tagttaaaag tttaatgtag   1680

ttcccaaata catttcatat gacaatctta cataaatgtt cc                      1722


<210>  3416
<211>  162
<212>  PRT
<213>  Homo sapiens

<400>  3416


Met Asp Ala Val Asp Ala Thr Met Glu Lys Leu Arg Ala Gln Cys Leu 
1               5                   10                  15      


Ser Arg Gly Ala Ser Gly Ile Gln Gly Leu Ala Arg Phe Phe Arg Gln 
            20                  25                  30          


Leu Asp Arg Asp Gly Ser Arg Ser Leu Asp Ala Asp Glu Phe Arg Gln 
        35                  40                  45              


Gly Leu Ala Lys Leu Gly Leu Val Leu Asp Gln Ala Glu Ala Glu Gly 
    50                  55                  60                  


Val Cys Arg Lys Trp Asp Arg Asn Gly Ser Gly Thr Leu Asp Leu Glu 
65                  70                  75                  80  


Glu Phe Leu Arg Ala Leu Arg Pro Pro Met Ser Gln Ala Arg Glu Ala 
                85                  90                  95      


Val Ile Ala Ala Ala Phe Ala Lys Leu Asp Arg Ser Gly Asp Gly Val 
            100                 105                 110         


Val Thr Val Asp Asp Leu Arg Gly Val Tyr Ser Gly Arg Ala His Pro 
        115                 120                 125             


Lys Val Thr Leu Ala Glu Phe Gln Asp Tyr Tyr Ser Gly Val Ser Ala 
    130                 135                 140                 


Ser Met Asn Thr Asp Glu Glu Phe Val Ala Met Met Thr Ser Ala Trp 
145                 150                 155                 160 


Gln Leu 
        

<210>  3417
<211>  1803
<212>  DNA
<213>  Homo sapiens

<400>  3417
agttccgggc cgcctggggg cgtggccggg cctgtacagc agcctgggcc atgtcggcgc     60

cgccggccct gcagatccgg gaggcaaacg cacacctggc agccgtgcac cggcgcgcag    120

cggagctgga ggcgcggctg gacgcggcgg agcgcacggt gcacgcccaa gccgagcgcc    180

tggccctcca cgaccagcag ctgcgcgccg ccctagacga actgggtcgc gccaaggacc    240

gaggcacctt ccactagcaa cagtctcccc aggcacaaca cagctaacac aaggccccgc    300

aggcaggact ctgggacaga cgcaggccag ctgcccagag cccagaccaa gcatggacgc    360

cgtggatgcc accatggaga aactccgggc acagtgcctg tcccgcgggg cctcgggcat    420

ccagggcctg gccaggtttt tccgccaact agaccgggac gggagcagat ccctggacgc    480

tgatgagttc cggcagggtc tggccaaact cgggctggtg ctggaccagg cggaggcaga    540

gggtgtgtgc aggaagtggg accgcaatgg cagcgggacg ctggatctgg aggagttcct    600

tcgggcgctg cggcccccca tgtcccaggc ccgggaggct gtcatcgcag ctgcatttgc    660

caagctggac cgcagtgggg acggcgtcgt gacggtggac gacctccgcg gggtgtacag    720

tggccgtgcc caccccaagg tgcgcagtgg ggagtggacc gaggacgagg tgctgcgccg    780

cttcctggac aacttcgact cctctgagaa ggacgggcag gtcacactgg cggaattcca    840

ggactactac agcggcgtga gtgcctccat gaacacggat gaggagttcg tggccatgat    900

gaccagtgcc tggcagctgt gagcagctcc ggctcagccc tgctgccctg gcctgtcact    960

ccccacccct gccggagacc tcccttccct gggccccttc tctcctgggc agccacacca   1020

cagagcgggg aggggcaggt gggggaatgg aggctgcagg actggctaga ccaggtccct   1080

gccggtccac caggcggagg tgggacaaag gtcctaacag gagtcactgg ctcaggaccc   1140

cagggagaaa cgctctcccc acccacgcca tgctgaccag agatcttgca gcccctgtgg   1200

atgcccccgc cgaggtcccc cgatccccgc acccggactg ctgctccctg cccctccctt   1260

gcgggtcccc caggaagcca ggtgacccca ggtgggaggc tgtgtgtgga ggccatcctg   1320

gaaggaagtt tagacctgcc caggtgtgga gcgaggggca caggggcatc ctaacctcag   1380

aaactgaaat aaagcctttg aaaaaaaaat ctgtaaaaca tcaaccccca atcagaagat   1440

ggcaaatggg gaataaaaat agcaggtaac atgtccagcg ggcccagtat ctacattctg   1500

gtgagcggcc cgaggctggg agctctgggc gggggcagac cggcggggcc ttgcagcagg   1560

ggtgggggta aagtgcgggt ggtggtggag agaacagggc tgtggctgga ccccagcact   1620

ggtgacacgc tgggtgggag catgaggccc caggctgctg gaggtcctcg cccggggagg   1680

tggaggccgt tcctggtcag gggcttcctg aggcccctgg ggcatgcaga ggccagggtt   1740

ttagttaaaa gtttaatgta gttcccaaat acatttcata tgacaatctt acataaatgt   1800

tcc                                                                 1803


<210>  3418
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  3418


Met Asp Ala Val Asp Ala Thr Met Glu Lys Leu Arg Ala Gln Cys Leu 
1               5                   10                  15      


Ser Arg Gly Ala Ser Gly Ile Gln Gly Leu Ala Arg Phe Phe Arg Gln 
            20                  25                  30          


Leu Asp Arg Asp Gly Ser Arg Ser Leu Asp Ala Asp Glu Phe Arg Gln 
        35                  40                  45              


Gly Leu Ala Lys Leu Gly Leu Val Leu Asp Gln Ala Glu Ala Glu Gly 
    50                  55                  60                  


Val Cys Arg Lys Trp Asp Arg Asn Gly Ser Gly Thr Leu Asp Leu Glu 
65                  70                  75                  80  


Glu Phe Leu Arg Ala Leu Arg Pro Pro Met Ser Gln Ala Arg Glu Ala 
                85                  90                  95      


Val Ile Ala Ala Ala Phe Ala Lys Leu Asp Arg Ser Gly Asp Gly Val 
            100                 105                 110         


Val Thr Val Asp Asp Leu Arg Gly Val Tyr Ser Gly Arg Ala His Pro 
        115                 120                 125             


Lys Val Arg Ser Gly Glu Trp Thr Glu Asp Glu Val Leu Arg Arg Phe 
    130                 135                 140                 


Leu Asp Asn Phe Asp Ser Ser Glu Lys Asp Gly Gln Val Thr Leu Ala 
145                 150                 155                 160 


Glu Phe Gln Asp Tyr Tyr Ser Gly Val Ser Ala Ser Met Asn Thr Asp 
                165                 170                 175     


Glu Glu Phe Val Ala Met Met Thr Ser Ala Trp Gln Leu 
            180                 185                 

<210>  3419
<211>  3084
<212>  DNA
<213>  Homo sapiens

<400>  3419
agttccgggc cgcctggggg cgtggccggg cctgtacagc agcctgggcc atgtcggcgc     60

cgccggccct gcagatccgg gaggcaaacg cacacctggc agccgtgcac cggcgcgcag    120

cggagctgga ggcgcggctg gacgcggcgg agcgcacggt gcacgcccaa gccgagcgcc    180

tggccctcca cgaccagcag ctgcgcgccg ccctagacga actgggtcgc gccaaggacc    240

gaggcacctt ccactagcaa cagtctcccc aggcacaaca cagctaacac aaggccccgc    300

aggcaggact ctgggacaga cgcaggccag ctgcccagag cccagaccaa gcatggacgc    360

cgtggatgcc accatggaga aactccgggc acagtgcctg tcccgcgggg cctcgggcat    420

ccagggcctg gccaggtttt tccgccaact agaccgggac gggagcagat ccctggacgc    480

tgatgagttc cggcagggtc tggccaaact cgggctggtg ctggaccagg cggaggcaga    540

gggtgtgtgc aggaagtggg accgcaatgg cagcgggacg ctggatctgg aggagttcct    600

tcgggcgctg cggcccccca tgtcccaggc ccgggaggct gtcatcgcag ctgcatttgc    660

caagctggac cgcagtgggg acggcgtcgt gacggtggac gacctccgcg gggtgtacag    720

tggccgtgcc caccccaagg tcacactggc ggaattccag gactactaca gcggcgtgag    780

tgcctccatg aacacggatg aggagttcgt ggccatgatg accagtgcct ggcagctgtg    840

agcagctccg gctcagccct gctgccctgg cctgtcactc cccacccctg ccggagacct    900

cccttccctg ggccccttct ctcctgggca gccacaccac agagcgggga ggggcaggtg    960

ggggaatgga ggctgcagga ctggctagac caggtccctg ccggtccacc aggcggaggt   1020

gggacaaagg tcctaacagg agtcactggc tcaggacccc agggagaaac gctctcccca   1080

cccacgccat gctgaccaga gatcttgcag cccctgtgga tgcccccgcc gaggtccccc   1140

gatccccgca cccggactgc tgctccctgc ccctcccttg cgggtccccc aggaagccag   1200

gtgaccccag gtgggaggct gtgtgtggag gccatcctgg aaggaagttt agacctgccc   1260

aggtgtggag cgaggggcac aggggcatcc taacctcaga aactgaaata aagcctttga   1320

aaaaaaaatc tgtaaaacat caacccccaa tcagaagatg gcaaatgggg aataaaaata   1380

gcaggtaaca tgtccagcgg gcccagtatc tacattctgg tgagcggccc gaggctggga   1440

gctctgggcg ggggcagacc ggcggggcct tgcagcaggg gtgggggtaa agtgcgggtg   1500

gtggtggaga gaacagggct gtggctggac cccagcactg gtgacacgct gggtgggagc   1560

atgaggcccc aggctgctgg aggtcctcgc ccggggaggt ggaggccgtt cctggtcagg   1620

ggcttcctga ggcccctggg gcatgcagag gccagggttt tagttaaaag tttaatgtag   1680

ttcccaaata catttcatat gacaatctta cataaatgtt ccaaaacaca tgggcgttat   1740

ctcgttgtac tcgtcactag ctggctaagg cttaaagcag agacgtgtga ctgggtctct   1800

cgggagggcc tctggttctt cccgggctca ggcttgctgg gggctggggg ccagggctct   1860

ggcgacctag aggtgtggac ggcacagctg caggaggcct tctcttaacc ctccgagagt   1920

gggactggga gatttcctct gaagtcccaa agaggccctg tgcccagggg acctcctcct   1980

cggcctccca ggtgggtggt gcaagctggc tcttggccat gctccaggct cgggtgggca   2040

caggcgtcca ctccagtgtg ctgcgtgctt gtgagactgc ctgttctggg accagcccct   2100

gggctcttcc accaagattt ggtgagggtc cccctctgcc tctcacagaa gcccctggcc   2160

ctggactgtc ctgggggcag ggacacctgt ggctggggaa gggatggcca acagcgggaa   2220

gcagtttgcg cctggtgcct gatgatggtg aaccacgtga cagatggaga cgggagtcag   2280

gggaccctgg ggacccttcc aggtccagtg accttttccc agacaggcac tctccaggcc   2340

taggacagac agggccccaa ctcctcatca ccccatgact tggcctggag gaacctgggg   2400

tgggaaacaa gtagtccccc aacctcagag gccagaacca caggtggggg acagggacct   2460

cgacagagct gtgcctgctc aacgctcgag agcatcttaa cctaagaaac caaaacaaag   2520

ccttcgaaaa taaaaagaaa aaaagatgta aaatatacac ccccaatcag agaggggaag   2580

tgggaaatga agatagtagt taacagcacg tccaatgggc ccagtgtcta cactcgtacg   2640

agcagccccc caagctgggc gggggtccca ggcctatagt tggggagccc tgggcagggg   2700

cagagggctg gctgctcccc acaaaggcag ggccccacag cagggtggga agggtgtggg   2760

tggcggagaa gccaggggct ctggctggac ccagaggctg gcgacacgcg gggtgaagga   2820

acgaggtctc cagtcccagt gagaagccgt gacaagtctt aatgtgccat ttcaattcaa   2880

aggaggggag ggaggaaatg ttcttgtttg ttcgctcatc aatatgatga ggtctcgtgt   2940

cccaaaccac attcaggcag ttcccgagtc tgcttttgaa caggacgtgc gggtccagac   3000

tgtggccggc ccagtggggt gtgtggttcc cggccccgca cctggacgct gccggtgggg   3060

tgggggcggg tgggcgggtg gata                                          3084


<210>  3420
<211>  162
<212>  PRT
<213>  Homo sapiens

<400>  3420


Met Asp Ala Val Asp Ala Thr Met Glu Lys Leu Arg Ala Gln Cys Leu 
1               5                   10                  15      


Ser Arg Gly Ala Ser Gly Ile Gln Gly Leu Ala Arg Phe Phe Arg Gln 
            20                  25                  30          


Leu Asp Arg Asp Gly Ser Arg Ser Leu Asp Ala Asp Glu Phe Arg Gln 
        35                  40                  45              


Gly Leu Ala Lys Leu Gly Leu Val Leu Asp Gln Ala Glu Ala Glu Gly 
    50                  55                  60                  


Val Cys Arg Lys Trp Asp Arg Asn Gly Ser Gly Thr Leu Asp Leu Glu 
65                  70                  75                  80  


Glu Phe Leu Arg Ala Leu Arg Pro Pro Met Ser Gln Ala Arg Glu Ala 
                85                  90                  95      


Val Ile Ala Ala Ala Phe Ala Lys Leu Asp Arg Ser Gly Asp Gly Val 
            100                 105                 110         


Val Thr Val Asp Asp Leu Arg Gly Val Tyr Ser Gly Arg Ala His Pro 
        115                 120                 125             


Lys Val Thr Leu Ala Glu Phe Gln Asp Tyr Tyr Ser Gly Val Ser Ala 
    130                 135                 140                 


Ser Met Asn Thr Asp Glu Glu Phe Val Ala Met Met Thr Ser Ala Trp 
145                 150                 155                 160 


Gln Leu 
        

<210>  3421
<211>  3165
<212>  DNA
<213>  Homo sapiens

<400>  3421
agttccgggc cgcctggggg cgtggccggg cctgtacagc agcctgggcc atgtcggcgc     60

cgccggccct gcagatccgg gaggcaaacg cacacctggc agccgtgcac cggcgcgcag    120

cggagctgga ggcgcggctg gacgcggcgg agcgcacggt gcacgcccaa gccgagcgcc    180

tggccctcca cgaccagcag ctgcgcgccg ccctagacga actgggtcgc gccaaggacc    240

gaggcacctt ccactagcaa cagtctcccc aggcacaaca cagctaacac aaggccccgc    300

aggcaggact ctgggacaga cgcaggccag ctgcccagag cccagaccaa gcatggacgc    360

cgtggatgcc accatggaga aactccgggc acagtgcctg tcccgcgggg cctcgggcat    420

ccagggcctg gccaggtttt tccgccaact agaccgggac gggagcagat ccctggacgc    480

tgatgagttc cggcagggtc tggccaaact cgggctggtg ctggaccagg cggaggcaga    540

gggtgtgtgc aggaagtggg accgcaatgg cagcgggacg ctggatctgg aggagttcct    600

tcgggcgctg cggcccccca tgtcccaggc ccgggaggct gtcatcgcag ctgcatttgc    660

caagctggac cgcagtgggg acggcgtcgt gacggtggac gacctccgcg gggtgtacag    720

tggccgtgcc caccccaagg tgcgcagtgg ggagtggacc gaggacgagg tgctgcgccg    780

cttcctggac aacttcgact cctctgagaa ggacgggcag gtcacactgg cggaattcca    840

ggactactac agcggcgtga gtgcctccat gaacacggat gaggagttcg tggccatgat    900

gaccagtgcc tggcagctgt gagcagctcc ggctcagccc tgctgccctg gcctgtcact    960

ccccacccct gccggagacc tcccttccct gggccccttc tctcctgggc agccacacca   1020

cagagcgggg aggggcaggt gggggaatgg aggctgcagg actggctaga ccaggtccct   1080

gccggtccac caggcggagg tgggacaaag gtcctaacag gagtcactgg ctcaggaccc   1140

cagggagaaa cgctctcccc acccacgcca tgctgaccag agatcttgca gcccctgtgg   1200

atgcccccgc cgaggtcccc cgatccccgc acccggactg ctgctccctg cccctccctt   1260

gcgggtcccc caggaagcca ggtgacccca ggtgggaggc tgtgtgtgga ggccatcctg   1320

gaaggaagtt tagacctgcc caggtgtgga gcgaggggca caggggcatc ctaacctcag   1380

aaactgaaat aaagcctttg aaaaaaaaat ctgtaaaaca tcaaccccca atcagaagat   1440

ggcaaatggg gaataaaaat agcaggtaac atgtccagcg ggcccagtat ctacattctg   1500

gtgagcggcc cgaggctggg agctctgggc gggggcagac cggcggggcc ttgcagcagg   1560

ggtgggggta aagtgcgggt ggtggtggag agaacagggc tgtggctgga ccccagcact   1620

ggtgacacgc tgggtgggag catgaggccc caggctgctg gaggtcctcg cccggggagg   1680

tggaggccgt tcctggtcag gggcttcctg aggcccctgg ggcatgcaga ggccagggtt   1740

ttagttaaaa gtttaatgta gttcccaaat acatttcata tgacaatctt acataaatgt   1800

tccaaaacac atgggcgtta tctcgttgta ctcgtcacta gctggctaag gcttaaagca   1860

gagacgtgtg actgggtctc tcgggagggc ctctggttct tcccgggctc aggcttgctg   1920

ggggctgggg gccagggctc tggcgaccta gaggtgtgga cggcacagct gcaggaggcc   1980

ttctcttaac cctccgagag tgggactggg agatttcctc tgaagtccca aagaggccct   2040

gtgcccaggg gacctcctcc tcggcctccc aggtgggtgg tgcaagctgg ctcttggcca   2100

tgctccaggc tcgggtgggc acaggcgtcc actccagtgt gctgcgtgct tgtgagactg   2160

cctgttctgg gaccagcccc tgggctcttc caccaagatt tggtgagggt ccccctctgc   2220

ctctcacaga agcccctggc cctggactgt cctgggggca gggacacctg tggctgggga   2280

agggatggcc aacagcggga agcagtttgc gcctggtgcc tgatgatggt gaaccacgtg   2340

acagatggag acgggagtca ggggaccctg gggacccttc caggtccagt gaccttttcc   2400

cagacaggca ctctccaggc ctaggacaga cagggcccca actcctcatc accccatgac   2460

ttggcctgga ggaacctggg gtgggaaaca agtagtcccc caacctcaga ggccagaacc   2520

acaggtgggg gacagggacc tcgacagagc tgtgcctgct caacgctcga gagcatctta   2580

acctaagaaa ccaaaacaaa gccttcgaaa ataaaaagaa aaaaagatgt aaaatataca   2640

cccccaatca gagaggggaa gtgggaaatg aagatagtag ttaacagcac gtccaatggg   2700

cccagtgtct acactcgtac gagcagcccc ccaagctggg cgggggtccc aggcctatag   2760

ttggggagcc ctgggcaggg gcagagggct ggctgctccc cacaaaggca gggccccaca   2820

gcagggtggg aagggtgtgg gtggcggaga agccaggggc tctggctgga cccagaggct   2880

ggcgacacgc ggggtgaagg aacgaggtct ccagtcccag tgagaagccg tgacaagtct   2940

taatgtgcca tttcaattca aaggagggga gggaggaaat gttcttgttt gttcgctcat   3000

caatatgatg aggtctcgtg tcccaaacca cattcaggca gttcccgagt ctgcttttga   3060

acaggacgtg cgggtccaga ctgtggccgg cccagtgggg tgtgtggttc ccggccccgc   3120

acctggacgc tgccggtggg gtgggggcgg gtgggcgggt ggata                   3165


<210>  3422
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  3422


Met Asp Ala Val Asp Ala Thr Met Glu Lys Leu Arg Ala Gln Cys Leu 
1               5                   10                  15      


Ser Arg Gly Ala Ser Gly Ile Gln Gly Leu Ala Arg Phe Phe Arg Gln 
            20                  25                  30          


Leu Asp Arg Asp Gly Ser Arg Ser Leu Asp Ala Asp Glu Phe Arg Gln 
        35                  40                  45              


Gly Leu Ala Lys Leu Gly Leu Val Leu Asp Gln Ala Glu Ala Glu Gly 
    50                  55                  60                  


Val Cys Arg Lys Trp Asp Arg Asn Gly Ser Gly Thr Leu Asp Leu Glu 
65                  70                  75                  80  


Glu Phe Leu Arg Ala Leu Arg Pro Pro Met Ser Gln Ala Arg Glu Ala 
                85                  90                  95      


Val Ile Ala Ala Ala Phe Ala Lys Leu Asp Arg Ser Gly Asp Gly Val 
            100                 105                 110         


Val Thr Val Asp Asp Leu Arg Gly Val Tyr Ser Gly Arg Ala His Pro 
        115                 120                 125             


Lys Val Arg Ser Gly Glu Trp Thr Glu Asp Glu Val Leu Arg Arg Phe 
    130                 135                 140                 


Leu Asp Asn Phe Asp Ser Ser Glu Lys Asp Gly Gln Val Thr Leu Ala 
145                 150                 155                 160 


Glu Phe Gln Asp Tyr Tyr Ser Gly Val Ser Ala Ser Met Asn Thr Asp 
                165                 170                 175     


Glu Glu Phe Val Ala Met Met Thr Ser Ala Trp Gln Leu 
            180                 185                 

<210>  3423
<211>  1651
<212>  DNA
<213>  Homo sapiens

<400>  3423
gggcgtggcc gggcctgtac agcagcctgg gccatgtcgg cgccgccggc cctgcagatc     60

cgggaggcaa acgcacacct ggcagccgtg caccggcgcg cagcggagct ggaggcgcgg    120

ctggacgcgg cggagcgcac ggtgcacgcc caagccgagc gcctggccct ccacgaccag    180

cagctgcgcg ccgccctaga cgaactgggt cgcgccaagg accgtgagat tgccacactc    240

caggagcagc tgatgacctc agaagccact gtccacagcc tgcaggccac cgtgcaccag    300

agggacgagc tcattaggca gttgcagccc cgggctgagc tgctgcagga catctgccgc    360

cgccggccac ccctggctgg gctgctggat gccctggctg aggctgagcg cctggggccc    420

ctgccggcca gtgaccccgg ccacccaccc cccggtgggc ctggtccacc ccttgacaac    480

agcactgggg aagaggcgga cagggaccac ctccagcctg cagtgtttgg gaccacagtg    540

tgagcccgga atgcagatta cagaatggag acagaaagcc actgctgtca gtgtccttgg    600

gagtcaccag caccctgcag ggggacccta cggcagagcc aaagtcctgt ctaagcatca    660

gaacaggctg aacagtcaaa aagttttcaa ataggcccac aggccaggtg cagacgttta    720

acccagacag aagtgttctt gtttgttttt aagctttgaa tcagtcaccc ttgctaaaaa    780

cctggcaatg caaacacaaa gatctggatt tctggcaaga cttggccaag cttgcctgga    840

gttcagggca ccctctttag ccagggtgtg agtttctgtt ttttgttttt ttttttttaa    900

gacagagtcc cactctgtcg ccctggctgg ggtgcagtgg tgcgattttg gctaactgca    960

acctccgcct cccaggttca agcgattctc ctgtctcatc cttcagagta gctgggatta   1020

caggcgccca ccaccacacc cggatatttt atatttttgg tagagaccgg ggaggggagg   1080

gggtttcacc atgttgacca ggctggtctc aaactcctga ccttaggtga tccacccgcc   1140

tcggccttcg aaagtgctgc agttataggt gtaagccacc gcgcccggcc ctagcctagc   1200

ttttgtagca tgcaactgtc tcctttttat acgccctaaa gaatatattt ttgaactcct   1260

tgtttctgcg ctgtccttct tagcccagga cattcagggt gctttgcttg ttgtcaaacc   1320

agggaaagga gaaaactcct gtgcctttct gggccagcct gtcaccctgg cctggtcggc   1380

agccattccc ctacctcctc actcaggaac tgtcacacca ggaaccggcg aggggcacag   1440

cctgtttcag accagaaagg tcggaggcca cccacggcct tcaggatggc gcccgcctgc   1500

ctgcctggca acagtgaccc ctcagtgcag taacaatggg cccattttct cctctggatg   1560

aacaaggagg ggggttgttt gtacaaagga aaggcaggct ggggcctgtc tgtgctcaag   1620

aataaaccgg atgatttcct ggcctggggg c                                  1651


<210>  3424
<211>  169
<212>  PRT
<213>  Homo sapiens

<400>  3424


Met Ser Ala Pro Pro Ala Leu Gln Ile Arg Glu Ala Asn Ala His Leu 
1               5                   10                  15      


Ala Ala Val His Arg Arg Ala Ala Glu Leu Glu Ala Arg Leu Asp Ala 
            20                  25                  30          


Ala Glu Arg Thr Val His Ala Gln Ala Glu Arg Leu Ala Leu His Asp 
        35                  40                  45              


Gln Gln Leu Arg Ala Ala Leu Asp Glu Leu Gly Arg Ala Lys Asp Arg 
    50                  55                  60                  


Glu Ile Ala Thr Leu Gln Glu Gln Leu Met Thr Ser Glu Ala Thr Val 
65                  70                  75                  80  


His Ser Leu Gln Ala Thr Val His Gln Arg Asp Glu Leu Ile Arg Gln 
                85                  90                  95      


Leu Gln Pro Arg Ala Glu Leu Leu Gln Asp Ile Cys Arg Arg Arg Pro 
            100                 105                 110         


Pro Leu Ala Gly Leu Leu Asp Ala Leu Ala Glu Ala Glu Arg Leu Gly 
        115                 120                 125             


Pro Leu Pro Ala Ser Asp Pro Gly His Pro Pro Pro Gly Gly Pro Gly 
    130                 135                 140                 


Pro Pro Leu Asp Asn Ser Thr Gly Glu Glu Ala Asp Arg Asp His Leu 
145                 150                 155                 160 


Gln Pro Ala Val Phe Gly Thr Thr Val 
                165                 

<210>  3425
<211>  2254
<212>  DNA
<213>  Homo sapiens

<400>  3425
gggcgtggcc gggcctgtac agcagcctgg gccatgtcgg cgccgccggc cctgcagatc     60

cgggaggcaa acgcacacct ggcagccgtg caccggcgcg cagcggagct ggaggcgcgg    120

ctggacgcgg cggagcgcac ggtgcacgcc caagccgagc gcctggccct ccacgaccag    180

cagctgcgcg ccgccctaga cgaactgggt cgcgccaagg accgtgagat tgccacactc    240

caggagcagc tgatgacctc agaagccact gtccacagcc tgcaggccac cgtgcaccag    300

agggacgagc tcattaggca gttgcagccc cgggctgagc tgctgcagga catctgccgc    360

cgccggccac ccctggctgg gctgctggat gccctggctg aggctgagcg cctggggccc    420

ctgccggcca gtgaccccgg ccacccaccc cccggtgggc ctggtccacc ccttgacaac    480

agcactgggg aagaggcgga cagggaccac ctccagcctg cagtgtttgg gaccacagtg    540

tgagcccgga atgcagatta cagaatggag acagaaagcc actgctgtca gtgtccttgg    600

gagtcaccag caccctgcag ggggacccta cggcagagcc aaagtcctgt ctaagcatca    660

gaacaggctg aacagtcaaa aagttttcaa ataggcccac aggccaggtg cagacgttta    720

acccagacag aagtgttctt gtttgttttt aagctttgaa tcagtcaccc ttgctaaaaa    780

cctggcaatg caaacacaaa gatctggatt tctggcaaga cttggccaag cttgcctgga    840

gttcagggca ccctctttag ccagggtgtg agtttctgtt ttttgttttt ttttttttaa    900

gacagagtcc cactctgtcg ccctggctgg ggtgcagtgg tgcgattttg gctaactgca    960

acctccgcct cccaggttca agcgattctc ctgtctcatc cttcagagta gctgggatta   1020

caggcgccca ccaccacacc cggatatttt atatttttgg tagagaccgg ggaggggagg   1080

gggtttcacc atgttgacca ggctggtctc aaactcctga ccttaggtga tccacccgcc   1140

tcggccttcg aaagtgctgc agttataggt gtaagccacc gcgcccggcc ctagcctagc   1200

ttttgtagca tgcaactgtc tcctttttat acgccctaaa gaatatattt ttgaactcct   1260

tgtttctgcg ctgtccttct tagcccagga cattcagggt gctttgcttg ttgtcaaacc   1320

agggaaagga gaaaactcct gtgcctttct gggccagcct gtcaccctgg cctggtcggc   1380

agccattccc ctacctcctc actcaggaac tgtcacacca ggaaccggcg aggggcacag   1440

cctgtttcag accagaaagg tcggaggcca cccacggcct tcaggatggc gcccgcctgc   1500

ctgcctggca acagtgaccc ctcagtgcag taacaatggg cccattttct cctctggatg   1560

aacaaggagg ggggttgttt gtacaaagga aaggcaggct ggggcctgtc tgtgctcaag   1620

aataaaccgg atgatttcct ggcctggggg caagagggag gccctctgtg ttatttgtgc   1680

ctcctggtag ggtcctgctg ggccaggtag aatctaggga gtgtaggcca agcactctct   1740

acagcgattg catctaatct tcgagtttcc ctgtagacac aggctttgtc ctcattttac   1800

agctgtggaa agtgaggccc aggccgggcg cggtgtctca cgcctgtaat cccagcactt   1860

tgggatgcgg gtggatcacc tgaggtcagg agttcgagac caccctggcc aacatggtga   1920

aaccccgtct ctactaaaaa tactaaaatt agccgggctt ggtggcgggt gcctgtaatc   1980

ccagctactg aacccgggag gcggaggttg cagtgagtgg agattgcacc actgcactcc   2040

agcctgggag acagagtgag actcagtctc aaagaaaaca acaacaacaa caacaacaac   2100

aacaacaaca acaaacagag gcccagaggt gtgaagggaa cacactccgg gtctggaggg   2160

ccagggccac ttccaattct gggggaagtt attgctgaaa ttctgttttc tttctttctt   2220

tctttttttt ttaaagagac aaagtctcac tgtt                               2254


<210>  3426
<211>  169
<212>  PRT
<213>  Homo sapiens

<400>  3426


Met Ser Ala Pro Pro Ala Leu Gln Ile Arg Glu Ala Asn Ala His Leu 
1               5                   10                  15      


Ala Ala Val His Arg Arg Ala Ala Glu Leu Glu Ala Arg Leu Asp Ala 
            20                  25                  30          


Ala Glu Arg Thr Val His Ala Gln Ala Glu Arg Leu Ala Leu His Asp 
        35                  40                  45              


Gln Gln Leu Arg Ala Ala Leu Asp Glu Leu Gly Arg Ala Lys Asp Arg 
    50                  55                  60                  


Glu Ile Ala Thr Leu Gln Glu Gln Leu Met Thr Ser Glu Ala Thr Val 
65                  70                  75                  80  


His Ser Leu Gln Ala Thr Val His Gln Arg Asp Glu Leu Ile Arg Gln 
                85                  90                  95      


Leu Gln Pro Arg Ala Glu Leu Leu Gln Asp Ile Cys Arg Arg Arg Pro 
            100                 105                 110         


Pro Leu Ala Gly Leu Leu Asp Ala Leu Ala Glu Ala Glu Arg Leu Gly 
        115                 120                 125             


Pro Leu Pro Ala Ser Asp Pro Gly His Pro Pro Pro Gly Gly Pro Gly 
    130                 135                 140                 


Pro Pro Leu Asp Asn Ser Thr Gly Glu Glu Ala Asp Arg Asp His Leu 
145                 150                 155                 160 


Gln Pro Ala Val Phe Gly Thr Thr Val 
                165                 

<210>  3427
<211>  863
<212>  DNA
<213>  Homo sapiens

<400>  3427
tcataaaact gatgatgtta catcagtggt ggcctgaatc aagatgctgg gatgcctgta     60

acctacagat tggtttcaga ctccaaaggc aacttttttt tttttttttt tttgagacgg    120

agtctggctc tgccaccctg ccacccaggc tggagtgcag tggtgcgatc atagctcact    180

gcactccacc tcctgggttc aagcgattct cctgcctcag cttcctaagt agctcggatt    240

acaggcgccc accatcatgc acggctaatt tttgtatttt tagtagaggc ggggtttcac    300

catgttggtc aggctggtct caaactcctc accttgtgat ctgcccacct cggcctccca    360

aagtgctggg attacaggca tgagccaccg cgcccagccc acctggggca tttttgttgc    420

tgtacaatag aaacaagttc tctatatgtt ccccaggctg gtccaaactc ctgggctcaa    480

gtgatcctcc cacctagacc tcccaaagtg ctgggatttc aggcatgagc cgcagtggcc    540

ggtcagaacc tggggccctt ttgaactttg attcctcagc aattttgtca gccctggctc    600

gggctgagaa gcccctgtga agccagagag ggaaagggac ctgtccaggg tcacacagga    660

atcatgcgtc aagcctcccc agccacggac ttgtctccat ccagggcatt tcagcccctg    720

cagggcagtg gcctgcccct cctccttgga gccaggaagg gatgcagtgc cacagggatc    780

tggctctgtc ccaggccctg tggggctggc agttgagtaa gcagtcaggc tgggcgcacc    840

catccctccc ccactcccca ctg                                            863


<210>  3428
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  3428


Met Met Leu His Gln Trp Trp Pro Glu Ser Arg Cys Trp Asp Ala Cys 
1               5                   10                  15      


Asn Leu Gln Ile Gly Phe Arg Leu Gln Arg Gln Leu Phe Phe Phe Phe 
            20                  25                  30          


Phe Phe Glu Thr Glu Ser Gly Ser Ala Thr Leu Pro Pro Arg Leu Glu 
        35                  40                  45              


Cys Ser Gly Ala Ile Ile Ala His Cys Thr Pro Pro Pro Gly Phe Lys 
    50                  55                  60                  


Arg Phe Ser Cys Leu Ser Phe Leu Ser Ser Ser Asp Tyr Arg Arg Pro 
65                  70                  75                  80  


Pro Ser Cys Thr Ala Asn Phe Cys Ile Phe Ser Arg Gly Gly Val Ser 
                85                  90                  95      


Pro Cys Trp Ser Gly Trp Ser Gln Thr Pro His Leu Val Ile Cys Pro 
            100                 105                 110         


Pro Arg Pro Pro Lys Val Leu Gly Leu Gln Ala 
        115                 120             

<210>  3429
<211>  510
<212>  DNA
<213>  Homo sapiens

<400>  3429
aacacagcta acacaaggcc ccgcaggcag gactctggga cagacgcagg ccagctgccc     60

agagcccaga ccaagcatgg acgccgtgga tgccaccatg gagaaactcc gggcacagtg    120

cctgtcccgc ggggcctcgg gcatccaggg cctggccagg tttttccgcc aactagaccg    180

ggacgggagc agatccctgg acgctgatga gttccggcag ggtctggcca aactcgggct    240

ggtgctggac caggcggagg cagagggtgt gtgcaggaag tgggaccgca atggcagcgg    300

gacgctggat ctggaggagt tccttcgggc gctgcgggtg agcccccacc tcacagtcaa    360

ggcgtgtgcc ctgggcatgg ggcgacagag gatgctgaga tgcggagacg gggactcctc    420

cctaagagct gctgttaaga ggcgcctgct ggggcataca gccccagtgc tctgcacagc    480

gtcttggggg tttgggtgtg ctacccacca                                     510


<210>  3430
<211>  143
<212>  PRT
<213>  Homo sapiens

<400>  3430


Met Asp Ala Val Asp Ala Thr Met Glu Lys Leu Arg Ala Gln Cys Leu 
1               5                   10                  15      


Ser Arg Gly Ala Ser Gly Ile Gln Gly Leu Ala Arg Phe Phe Arg Gln 
            20                  25                  30          


Leu Asp Arg Asp Gly Ser Arg Ser Leu Asp Ala Asp Glu Phe Arg Gln 
        35                  40                  45              


Gly Leu Ala Lys Leu Gly Leu Val Leu Asp Gln Ala Glu Ala Glu Gly 
    50                  55                  60                  


Val Cys Arg Lys Trp Asp Arg Asn Gly Ser Gly Thr Leu Asp Leu Glu 
65                  70                  75                  80  


Glu Phe Leu Arg Ala Leu Arg Val Ser Pro His Leu Thr Val Lys Ala 
                85                  90                  95      


Cys Ala Leu Gly Met Gly Arg Gln Arg Met Leu Arg Cys Gly Asp Gly 
            100                 105                 110         


Asp Ser Ser Leu Arg Ala Ala Val Lys Arg Arg Leu Leu Gly His Thr 
        115                 120                 125             


Ala Pro Val Leu Cys Thr Ala Ser Trp Gly Phe Gly Cys Ala Thr 
    130                 135                 140             

<210>  3431
<211>  784
<212>  DNA
<213>  Homo sapiens

<400>  3431
ggccccgcag gcaggactct gggacagacg caggccagct gcccagagcc cagaccaagc     60

atggacgccg tggatgccac catggagaaa ctccgggcac agtgcctgtc ccgcggggcc    120

tcgggcatcc agggcctggc caggtgagct gtcccctctc accttcctga ccccggcccc    180

tgagaccact gttccaaccg tgtcccctgc ctccaggttt ttccgccaac tagaccggga    240

cgggagcaga tccctggacg ctgatgagtt ccggcagggt ctggccaaac tcgggctggt    300

gctggaccag gcggaggcag agggtgtgtg caggaagtgg gaccgcaatg gcagcgggac    360

gctggatctg gaggagttcc ttcgggcgct gcgggtgagc ccccacctca cagtcaaggc    420

gtgtgccctg ggcatggggc gacagaggat gctgagatgc ggagacgggg actcctccct    480

aagagctgct gttaagaggc gcctgctggg gcatacagcc ccagtgctct gcacagcgtc    540

ttgggggttt gggtgtgcta cccaccaccc ccagtcacca cctcctgtcc cagcccccca    600

tgtcccaggc ccgggaggct gtcatcgcag ctgcatttgc caagctggac cgcagtgggg    660

acggcgtcgt gacggtggac gacctccgcg gggtgtacag tggccgtgcc caccccaagg    720

tgcgcagtgg ggagtggacc gaggacgagg tgctgcgccg cttcctggac aacttcgact    780

cctc                                                                 784


<210>  3432
<211>  236
<212>  PRT
<213>  Homo sapiens

<400>  3432


Met Pro Pro Trp Arg Asn Ser Gly His Ser Ala Cys Pro Ala Gly Pro 
1               5                   10                  15      


Arg Ala Ser Arg Ala Trp Pro Gly Glu Leu Ser Pro Leu Thr Phe Leu 
            20                  25                  30          


Thr Pro Ala Pro Glu Thr Thr Val Pro Thr Val Ser Pro Ala Ser Arg 
        35                  40                  45              


Phe Phe Arg Gln Leu Asp Arg Asp Gly Ser Arg Ser Leu Asp Ala Asp 
    50                  55                  60                  


Glu Phe Arg Gln Gly Leu Ala Lys Leu Gly Leu Val Leu Asp Gln Ala 
65                  70                  75                  80  


Glu Ala Glu Gly Val Cys Arg Lys Trp Asp Arg Asn Gly Ser Gly Thr 
                85                  90                  95      


Leu Asp Leu Glu Glu Phe Leu Arg Ala Leu Arg Val Ser Pro His Leu 
            100                 105                 110         


Thr Val Lys Ala Cys Ala Leu Gly Met Gly Arg Gln Arg Met Leu Arg 
        115                 120                 125             


Cys Gly Asp Gly Asp Ser Ser Leu Arg Ala Ala Val Lys Arg Arg Leu 
    130                 135                 140                 


Leu Gly His Thr Ala Pro Val Leu Cys Thr Ala Ser Trp Gly Phe Gly 
145                 150                 155                 160 


Cys Ala Thr His His Pro Gln Ser Pro Pro Pro Val Pro Ala Pro His 
                165                 170                 175     


Val Pro Gly Pro Gly Gly Cys His Arg Ser Cys Ile Cys Gln Ala Gly 
            180                 185                 190         


Pro Gln Trp Gly Arg Arg Arg Asp Gly Gly Arg Pro Pro Arg Gly Val 
        195                 200                 205             


Gln Trp Pro Cys Pro Pro Gln Gly Ala Gln Trp Gly Val Asp Arg Gly 
    210                 215                 220                 


Arg Gly Ala Ala Pro Leu Pro Gly Gln Leu Arg Leu 
225                 230                 235     

<210>  3433
<211>  1573
<212>  DNA
<213>  Homo sapiens

<400>  3433
gaggaggacg acagcgacga tgacgatgtc ctggctcctt caggggccac cgcagctggt     60

gctggtgacg aaggggacgg gcagacgacc gggagcacat agcggccggg agcccggctg    120

cacaccaggc tgctgctttg tccgtctatc cacccgccca cccgccccca ccccaccggc    180

agcgtccagg tgcggggccg ggaaccacac accccactgg gccggccaca gtctggaccc    240

gcacgtcctg ttcaaaagca gactcgggaa ctgcctgaat gtggtttggg acacgagacc    300

tcatcatatt gatgagcgaa caaacaagaa catttcctcc ctcccctcct ttgaattgaa    360

atggcacatt aagacttgtc acggcttctc actgggactg gagacctcgt tccttcaccc    420

cgcgtgtcgc cagcctctgg gtccagccag agcccctggc ttctccgcca cccacaccct    480

tcccaccctg ctgtggggcc ctgcctttgt ggggagcagc cagccctctg cccctgccca    540

gggctcccca actataggcc tgggaccccc gcccagcttg gggggctgct cgtacgagtg    600

tagacactgg gcccattgga cgtgctgtta actactatct tcatttccca cttcccctct    660

ctgattgggg gtgtatattt tacatctttt tttcttttta ttttcgaagg ctttgttttg    720

gtttcttagg ttaagatgct ctcgagcgtt gagcaggcac agctctgtcg aggtccctgt    780

cccccacctg tggttctggc ctctgaggtt gggggactac ttgtttccca ccccaggttc    840

ctccaggcca agtcatgggg tgatgaggag ttggggccct gtctgtccta ggcctggaga    900

gtgcctgtct gggaaaaggt cactggacct ggaagggtcc ccagggtccc ctgactcccg    960

tctccatctg tcacgtggtt caccatcatc aggcaccagg cgcaaactgc ttcccgctgt   1020

tggccatccc ttccccagcc acaggtgtcc ctgcccccag gacagtccag ggccaggggc   1080

ttctgtgaga ggcagagggg gaccctcacc aaatcttggt ggaagagccc aggggctggt   1140

cccagaacag gcagtctcac aagcacgcag cacactggag tggacgcctg tgcccacccg   1200

agcctggagc atggccaaga gccagcttgc accacccacc tgggaggccg aggaggaggt   1260

cccctgggca cagggcctct ttgggacttc agaggaaatc tcccagtccc actctcggag   1320

ggttaagaga aggcctcctg cagctgtgcc gtccacacct ctaggtcgcc agagccctgg   1380

cccccagccc ccagcaagcc tgagcccggg aagaaccaga ggccctcccg agagacccag   1440

tcacacgtct ctgctttaag ccttagccag ctagtgacga gtacaacgag ataacgccca   1500

tgtgttttgg aacatttatg taagattgtc atatgaaatg tatttgggaa ctacattaaa   1560

cttttaacta aaa                                                      1573


<210>  3434
<211>  203
<212>  PRT
<213>  Homo sapiens

<400>  3434


Met Thr Met Ser Trp Leu Leu Gln Gly Pro Pro Gln Leu Val Leu Val 
1               5                   10                  15      


Thr Lys Gly Thr Gly Arg Arg Pro Gly Ala His Ser Gly Arg Glu Pro 
            20                  25                  30          


Gly Cys Thr Pro Gly Cys Cys Phe Val Arg Leu Ser Thr Arg Pro Pro 
        35                  40                  45              


Ala Pro Thr Pro Pro Ala Ala Ser Arg Cys Gly Ala Gly Asn His Thr 
    50                  55                  60                  


Pro His Trp Ala Gly His Ser Leu Asp Pro His Val Leu Phe Lys Ser 
65                  70                  75                  80  


Arg Leu Gly Asn Cys Leu Asn Val Val Trp Asp Thr Arg Pro His His 
                85                  90                  95      


Ile Asp Glu Arg Thr Asn Lys Asn Ile Ser Ser Leu Pro Ser Phe Glu 
            100                 105                 110         


Leu Lys Trp His Ile Lys Thr Cys His Gly Phe Ser Leu Gly Leu Glu 
        115                 120                 125             


Thr Ser Phe Leu His Pro Ala Cys Arg Gln Pro Leu Gly Pro Ala Arg 
    130                 135                 140                 


Ala Pro Gly Phe Ser Ala Thr His Thr Leu Pro Thr Leu Leu Trp Gly 
145                 150                 155                 160 


Pro Ala Phe Val Gly Ser Ser Gln Pro Ser Ala Pro Ala Gln Gly Ser 
                165                 170                 175     


Pro Thr Ile Gly Leu Gly Pro Pro Pro Ser Leu Gly Gly Cys Ser Tyr 
            180                 185                 190         


Glu Cys Arg His Trp Ala His Trp Thr Cys Cys 
        195                 200             

<210>  3435
<211>  1606
<212>  DNA
<213>  Homo sapiens

<400>  3435
tgtgttccag atgcagtgca agctgtttgt ctttgacaag acctcacagt cctgggtgga     60

gagaggccgg gggctgctca gactcaatga catggcgtcc accgatggga cgggcagacg    120

accgggagca catagcggcc gggagcccgg ctgcacacca ggctgctgct ttgtccgtct    180

atccacccgc ccacccgccc ccaccccacc ggcagcgtcc aggtgcgggg ccgggaacca    240

cacaccccac tgggccggcc acagtctgga cccgcacgtc ctgttcaaaa gcagactcgg    300

gaactgcctg aatgtggttt gggacacgag acctcatcat attgatgagc gaacaaacaa    360

gaacatttcc tccctcccct cctttgaatt gaaatggcac attaagactt gtcacggctt    420

ctcactggga ctggagacct cgttccttca ccccgcgtgt cgccagcctc tgggtccagc    480

cagagcccct ggcttctccg ccacccacac ccttcccacc ctgctgtggg gccctgcctt    540

tgtggggagc agccagccct ctgcccctgc ccagggctcc ccaactatag gcctgggacc    600

cccgcccagc ttggggggct gctcgtacga gtgtagacac tgggcccatt ggacgtgctg    660

ttaactacta tcttcatttc ccacttcccc tctctgattg ggggtgtata ttttacatct    720

ttttttcttt ttattttcga aggctttgtt ttggtttctt aggttaagat gctctcgagc    780

gttgagcagg cacagctctg tcgaggtccc tgtcccccac ctgtggttct ggcctctgag    840

gttgggggac tacttgtttc ccaccccagg ttcctccagg ccaagtcatg gggtgatgag    900

gagttggggc cctgtctgtc ctaggcctgg agagtgcctg tctgggaaaa ggtcactgga    960

cctggaaggg tccccagggt cccctgactc ccgtctccat ctgtcacgtg gttcaccatc   1020

atcaggcacc aggcgcaaac tgcttcccgc tgttggccat cccttcccca gccacaggtg   1080

tccctgcccc caggacagtc cagggccagg ggcttctgtg agaggcagag ggggaccctc   1140

accaaatctt ggtggaagag cccaggggct ggtcccagaa caggcagtct cacaagcacg   1200

cagcacactg gagtggacgc ctgtgcccac ccgagcctgg agcatggcca agagccagct   1260

tgcaccaccc acctgggagg ccgaggagga ggtcccctgg gcacagggcc tctttgggac   1320

ttcagaggaa atctcccagt cccactctcg gagggttaag agaaggcctc ctgcagctgt   1380

gccgtccaca cctctaggtc gccagagccc tggcccccag cccccagcaa gcctgagccc   1440

gggaagaacc agaggccctc ccgagagacc cagtcacacg tctctgcttt aagccttagc   1500

cagctagtga cgagtacaac gagataacgc ccatgtgttt tggaacattt atgtaagatt   1560

gtcatatgaa atgtatttgg gaactacatt aaacttttaa ctaaaa                  1606


<210>  3436
<211>  217
<212>  PRT
<213>  Homo sapiens

<400>  3436


Met Gln Cys Lys Leu Phe Val Phe Asp Lys Thr Ser Gln Ser Trp Val 
1               5                   10                  15      


Glu Arg Gly Arg Gly Leu Leu Arg Leu Asn Asp Met Ala Ser Thr Asp 
            20                  25                  30          


Gly Thr Gly Arg Arg Pro Gly Ala His Ser Gly Arg Glu Pro Gly Cys 
        35                  40                  45              


Thr Pro Gly Cys Cys Phe Val Arg Leu Ser Thr Arg Pro Pro Ala Pro 
    50                  55                  60                  


Thr Pro Pro Ala Ala Ser Arg Cys Gly Ala Gly Asn His Thr Pro His 
65                  70                  75                  80  


Trp Ala Gly His Ser Leu Asp Pro His Val Leu Phe Lys Ser Arg Leu 
                85                  90                  95      


Gly Asn Cys Leu Asn Val Val Trp Asp Thr Arg Pro His His Ile Asp 
            100                 105                 110         


Glu Arg Thr Asn Lys Asn Ile Ser Ser Leu Pro Ser Phe Glu Leu Lys 
        115                 120                 125             


Trp His Ile Lys Thr Cys His Gly Phe Ser Leu Gly Leu Glu Thr Ser 
    130                 135                 140                 


Phe Leu His Pro Ala Cys Arg Gln Pro Leu Gly Pro Ala Arg Ala Pro 
145                 150                 155                 160 


Gly Phe Ser Ala Thr His Thr Leu Pro Thr Leu Leu Trp Gly Pro Ala 
                165                 170                 175     


Phe Val Gly Ser Ser Gln Pro Ser Ala Pro Ala Gln Gly Ser Pro Thr 
            180                 185                 190         


Ile Gly Leu Gly Pro Pro Pro Ser Leu Gly Gly Cys Ser Tyr Glu Cys 
        195                 200                 205             


Arg His Trp Ala His Trp Thr Cys Cys 
    210                 215         

<210>  3437
<211>  4106
<212>  DNA
<213>  Homo sapiens

<400>  3437
gtcgcccagg ctggagtgca gtggtacagt cgtaactcaa ctgtaacctc aagctcccag     60

gctcaagtga tcttcccacc tctgcctcct gagtagctgg gactacaggc atgtaccacc    120

atgcctggct aagtttttaa ttttttgtag agttagggtc ttgcagtgtt gcccaggctg    180

atctcaaact cttgggctca tgcagtcctc ctgcctcagc ctcccaaagc actgggatta    240

caggcatgag ccactgcacc cggccctaac attgttttat agttttatct tgtgaaatgt    300

attcccaagt attttattcc ttttggtgtt attgtaaatg gaattatttt cttaattttg    360

cttttgggtc attcactgct agtgttagaa acacaatcga tttttgtata ttgatcttgt    420

gtcctgtagc ttgacaaggg ggtgaagctt agcacaaacg cagggctacc tccaggagcc    480

ataatgccac agtctctgtg ccttgcccag gaacaggctt gcctgcctga gtcacaggcc    540

ttttatgaca atccttcctg ttgtggatca gattagacca ccatccccac tccctgtatg    600

ggcacagttg ccaagacaca cagatgaagg ggtccatgtg gacaggtggc tgggcgaggc    660

tgggctctcg agccatccca ggagctcgtg ggcattcacc tttccctcta gttttgtgaa    720

tttgtcagcc cggactctgg cccaggggga gctggcctcc tccacggtgg ccaggagtgc    780

cccctcactg agacgggaag ctccgcaggc acatctggaa aggggaggca ggctcactgt    840

gtgccacctt tgaccttttc atcacaaaaa cctgtctcac ttcccagaca tctgtagtgg    900

tgccaaggtt cttcctggcc acagccgcat cctctgacag acaagccttc taggaaaggg    960

aagtggggcc tgagcgcctg tgttccgtgg ctccctgaca ttctccagag ccaggtacag   1020

ggccgctgag cagctcggct cctgagcctg cagcaggtca tagacagctg ggagggcggc   1080

tgacgcccca cctgccccca tggtcagcag ctggcccaag agccatcgtt cctcctgccc   1140

ttgtctctcc cctcctccag gcgccttcca ggcctgctga tcggacgaga cttctgttgt   1200

aatttggaaa tgttctccct ggttctccag gcccgaagtc actgaggcca agaccatagt   1260

cctctcctgc ccttgccccc caggcccagc cccagcccag gcaggcctgc tgttgatatt   1320

ttgtcttgtg cttttagagg aaaggagcag tggcttccgg ttgaagccac caacgctgat   1380

ccacggccaa gcccccagcg caggtctgcc aagccagaag cccaaggagc agcagcggag   1440

cgtgcttcgc ccggcagtgt tacaagctcc gcagccaaag gcgctgtccc agactgtccc   1500

cagcagtggc accaacgggg tcagcctccc agcagactgc acgggggcag tgcccgcagc   1560

atcccctgac actgctgcat ggagaagtcc ttccgaagct gccgatgagg tgtgtgcact   1620

tgaggagaaa gagccccaga aaaatgagtc cagcaatgcc tctgaagagg aagcctgtga   1680

gaaaaaagac cccgccacac agcaagcctt tgtatttggg cagaacttga gggacagagt   1740

taagctgata aatgagagcg tggacgaagc cgacatggag aatgctggac accccagcgc   1800

agacacgcca accgcaacga actatttcct ccagtatatc agttccagtt tagagaactc   1860

aaccaatagt gccgacgcct ccagcaacaa atttgtattt ggccagaaca tgagcgagcg   1920

agttttgagc cccccaaaat taaacgaggt cagttcagat gccaacaggg aaaatgcagc   1980

tgccgagtca gggtctgagt cctcgtccca ggaggccacc cctgagaaag agtccctggc   2040

tgagtcggca gccgcctaca ccaaggcaac agcgcggaag tgtttgttgg aaaaagtgga   2100

agtcatcacc ggggaggagg cggagagcaa tgtgttacag atgcagtgca agctgtttgt   2160

ctttgacaag acctcacagt cctgggtgga gagaggccgg gggctgctca gactcaatga   2220

catggcgtcc accgatgacg gcacactaca gtcccgacta gtgatgcgga cccaggggag   2280

cctgcgactg atcctcaaca ccaagctgtg ggcccagatg cagatcgaca aggccagcga   2340

gaagagcatt cgcatcacag ccatggacac cgaggaccag ggcgtgaagg tcttcctgat   2400

ctcggccagc tccaaggaca caggtcagtt gtatgcagcc ctgcaccacc gcatcctggc   2460

cctgcgcagc cgcgtggagc aggagcagga ggccaagatg cccgcgcctg agcctggggc   2520

agccccatcc aacgaggagg acgacagcga cgatgacgat gtcctggctc cttcaggggc   2580

caccgcagct ggtgctggtg acgaagggga cgggcagacg accgggagca catagcggcc   2640

gggagcccgg ctgcacacca ggctgctgct ttgtccgtct atccacccgc ccacccgccc   2700

ccaccccacc ggcagcgtcc aggtgcgggg ccgggaacca cacaccccac tgggccggcc   2760

acagtctgga cccgcacgtc ctgttcaaaa gcagactcgg gaactgcctg aatgtggttt   2820

gggacacgag acctcatcat attgatgagc gaacaaacaa gaacatttcc tccctcccct   2880

cctttgaatt gaaatggcac attaagactt gtcacggctt ctcactggga ctggagacct   2940

cgttccttca ccccgcgtgt cgccagcctc tgggtccagc cagagcccct ggcttctccg   3000

ccacccacac ccttcccacc ctgctgtggg gccctgcctt tgtggggagc agccagccct   3060

ctgcccctgc ccagggctcc ccaactatag gcctgggacc cccgcccagc ttggggggct   3120

gctcgtacga gtgtagacac tgggcccatt ggacgtgctg ttaactacta tcttcatttc   3180

ccacttcccc tctctgattg ggggtgtata ttttacatct ttttttcttt ttattttcga   3240

aggctttgtt ttggtttctt aggttaagat gctctcgagc gttgagcagg cacagctctg   3300

tcgaggtccc tgtcccccac ctgtggttct ggcctctgag gttgggggac tacttgtttc   3360

ccaccccagg ttcctccagg ccaagtcatg gggtgatgag gagttggggc cctgtctgtc   3420

ctaggcctgg agagtgcctg tctgggaaaa ggtcactgga cctggaaggg tccccagggt   3480

cccctgactc ccgtctccat ctgtcacgtg gttcaccatc atcaggcacc aggcgcaaac   3540

tgcttcccgc tgttggccat cccttcccca gccacaggtg tccctgcccc caggacagtc   3600

cagggccagg ggcttctgtg agaggcagag ggggaccctc accaaatctt ggtggaagag   3660

cccaggggct ggtcccagaa caggcagtct cacaagcacg cagcacactg gagtggacgc   3720

ctgtgcccac ccgagcctgg agcatggcca agagccagct tgcaccaccc acctgggagg   3780

ccgaggagga ggtcccctgg gcacagggcc tctttgggac ttcagaggaa atctcccagt   3840

cccactctcg gagggttaag agaaggcctc ctgcagctgt gccgtccaca cctctaggtc   3900

gccagagccc tggcccccag cccccagcaa gcctgagccc gggaagaacc agaggccctc   3960

ccgagagacc cagtcacacg tctctgcttt aagccttagc cagctagtga cgagtacaac   4020

gagataacgc ccatgtgttt tggaacattt atgtaagatt gtcatatgaa atgtatttgg   4080

gaactacatt aaacttttaa ctaaaa                                        4106


<210>  3438
<211>  286
<212>  PRT
<213>  Homo sapiens

<400>  3438


Met Glu Asn Ala Gly His Pro Ser Ala Asp Thr Pro Thr Ala Thr Asn 
1               5                   10                  15      


Tyr Phe Leu Gln Tyr Ile Ser Ser Ser Leu Glu Asn Ser Thr Asn Ser 
            20                  25                  30          


Ala Asp Ala Ser Ser Asn Lys Phe Val Phe Gly Gln Asn Met Ser Glu 
        35                  40                  45              


Arg Val Leu Ser Pro Pro Lys Leu Asn Glu Val Ser Ser Asp Ala Asn 
    50                  55                  60                  


Arg Glu Asn Ala Ala Ala Glu Ser Gly Ser Glu Ser Ser Ser Gln Glu 
65                  70                  75                  80  


Ala Thr Pro Glu Lys Glu Ser Leu Ala Glu Ser Ala Ala Ala Tyr Thr 
                85                  90                  95      


Lys Ala Thr Ala Arg Lys Cys Leu Leu Glu Lys Val Glu Val Ile Thr 
            100                 105                 110         


Gly Glu Glu Ala Glu Ser Asn Val Leu Gln Met Gln Cys Lys Leu Phe 
        115                 120                 125             


Val Phe Asp Lys Thr Ser Gln Ser Trp Val Glu Arg Gly Arg Gly Leu 
    130                 135                 140                 


Leu Arg Leu Asn Asp Met Ala Ser Thr Asp Asp Gly Thr Leu Gln Ser 
145                 150                 155                 160 


Arg Leu Val Met Arg Thr Gln Gly Ser Leu Arg Leu Ile Leu Asn Thr 
                165                 170                 175     


Lys Leu Trp Ala Gln Met Gln Ile Asp Lys Ala Ser Glu Lys Ser Ile 
            180                 185                 190         


Arg Ile Thr Ala Met Asp Thr Glu Asp Gln Gly Val Lys Val Phe Leu 
        195                 200                 205             


Ile Ser Ala Ser Ser Lys Asp Thr Gly Gln Leu Tyr Ala Ala Leu His 
    210                 215                 220                 


His Arg Ile Leu Ala Leu Arg Ser Arg Val Glu Gln Glu Gln Glu Ala 
225                 230                 235                 240 


Lys Met Pro Ala Pro Glu Pro Gly Ala Ala Pro Ser Asn Glu Glu Asp 
                245                 250                 255     


Asp Ser Asp Asp Asp Asp Val Leu Ala Pro Ser Gly Ala Thr Ala Ala 
            260                 265                 270         


Gly Ala Gly Asp Glu Gly Asp Gly Gln Thr Thr Gly Ser Thr 
        275                 280                 285     

<210>  3439
<211>  3182
<212>  DNA
<213>  Homo sapiens

<400>  3439
agtaaaatgg cggacctggc gaacgaaggg ttatgctgca ttgtaggctg acatcaggat     60

ttgaaggcag agttttgtcc ctggcaaagg taaagaagac tggaaagagg aaaagcctgc    120

cattgctccg cccgtctttg tgtttcagaa ggataaagga caaaagtccc ctgcagagca    180

aaaaaacttg tcggattcgg gagaggagcc tcggggggag gctgaggccc cccaccatgg    240

cacgggtcac cccgagtcag ctggcgagca tgccctagaa cctcctgccc ctgctggcgc    300

ctcagccagc actcctccgc ctcccgctcc tgaagcccag cttcctcctt ttccgcgaga    360

actggcaggg aggtcagctg gcggctccag tcctgaaggc ggagaagatt ctgacagaga    420

agatggaaat tactgccctc ctgtcaagcg agaaagaaca tcctctttaa cccagttccc    480

accctcacag tcagaggaaa ggagcagtgg cttccggttg aagccaccaa cgctgatcca    540

cggccaagcc cccagcgcag gtctgccaag ccagaagccc aaggagcagc agcggagcgt    600

gcttcgcccg gcagtgttac aagctccgca gccaaaggcg ctgtcccaga ctgtccccag    660

cagtggcacc aacggggtca gcctcccagc agactgcacg ggggcagtgc ccgcagcatc    720

ccctgacact gctgcatgga gaagtccttc cgaagctgcc gatgaggtgt gtgcacttga    780

ggagaaagag ccccagaaaa atgagtccag caatgcctct gaagaggaag cctgtgagaa    840

aaaagacccc gccacacagc aagcctttgt atttgggcag aacttgaggg acagagttaa    900

gctgataaat gagagcgtgg acgaagccga catggagaat gctggacacc ccagcgcaga    960

cacgccaacc gcaacgaact atttcctcca gtatatcagt tccagtttag agaactcaac   1020

caatagtgcc gacgcctcca gcaacaaatt tgtatttggc cagaacatga gcgagcgagt   1080

tttgagcccc ccaaaattaa acgaggtcag ttcagatgcc aacagggaaa atgcagctgc   1140

cgagtcaggg tctgagtcct cgtcccagga ggccacccct gagaaagagt ccctggctga   1200

gtcggcagcc gcctacacca aggcaacagc gcggaagtgt ttgttggaaa aagtggaagt   1260

catcaccggg gaggaggcgg agagcaatgt gttacagatg cagtgcaagc tgtttgtctt   1320

tgacaagacc tcacagtcct gggtggagag aggccggggg ctgctcagac tcaatgacat   1380

ggcgtccacc gatgacggca cactacagtc ccgactagtg atgcggaccc aggggagcct   1440

gcgactgatc ctcaacacca agctgtgggc ccagatgcag atcgacaagg ccagcgagaa   1500

gagcattcgc atcacagcca tggacaccga ggaccagggc gtgaaggtct tcctgatctc   1560

ggccagctcc aaggacacag gtcagttgta tgcagccctg caccaccgca tcctggccct   1620

gcgcagccgc gtggagcagg agcaggaggc caagatgccc gcgcctgagc ctggggcagc   1680

cccatccaac gaggaggacg acagcgacga tgacgatgtc ctggctcctt caggggccac   1740

cgcagctggt gctggtgacg aaggggacgg gcagacgacc gggagcacat agcggccggg   1800

agcccggctg cacaccaggc tgctgctttg tccgtctatc cacccgccca cccgccccca   1860

ccccaccggc agcgtccagg tgcggggccg ggaaccacac accccactgg gccggccaca   1920

gtctggaccc gcacgtcctg ttcaaaagca gactcgggaa ctgcctgaat gtggtttggg   1980

acacgagacc tcatcatatt gatgagcgaa cgacctcgtt ccttcacccc gcgtgtcgcc   2040

agcctctggg tccagccaga gcccctggct tctccgccac ccacaccctt cccaccctgc   2100

tgtggggccc tgcctttgtg gggagcagcc agccctctgc ccctgcccag ggctccccaa   2160

ctataggcct gggacccccg cccagcttgg ggggctgctc gtacgagtgt agacactggg   2220

cccattggac gtgctgttaa ctactatctt catttcccac ttcccctctc tgattggggg   2280

tgtatatttt acatcttttt ttctttttat tttcgaaggc tttgttttgg tttcttaggt   2340

taagatgctc tcgagcgttg agcaggcaca gctctgtcga ggtccctgtc ccccacctgt   2400

ggttctggcc tctgaggttg ggggactact tgtttcccac cccaggttcc tccaggccaa   2460

gtcatggggt gatgaggagt tggggccctg tctgtcctag gcctggagag tgcctgtctg   2520

ggaaaaggtc actggacctg gaagggtccc cagggtcccc tgactcccgt ctccatctgt   2580

cacgtggttc accatcatca ggcaccaggc gcaaactgct tcccgctgtt ggccatccct   2640

tccccagcca caggtgtccc tgcccccagg acagtccagg gccaggggct tctgtgagag   2700

gcagaggggg accctcacca aatcttggtg gaagagccca ggggctggtc ccagaacagg   2760

cagtctcaca agcacgcagc acactggagt ggacgcctgt gcccacccga gcctggagca   2820

tggccaagag ccagcttgca ccacccacct gggaggccga ggaggaggtc ccctgggcac   2880

agggcctctt tgggacttca gaggaaatct cccagtccca ctctcggagg gttaagagaa   2940

ggcctcctgc agctgtgccg tccacacctc taggtcgcca gagccctggc ccccagcccc   3000

cagcaagcct gagcccggga agaaccagag gccctcccga gagacccagt cacacgtctc   3060

tgctttaagc cttagccagc tagtgacgag tacaacgaga taacgcccat gtgttttgga   3120

acatttatgt aagattgtca tatgaaatgt atttgggaac tacattaaac ttttaactaa   3180

aa                                                                  3182


<210>  3440
<211>  286
<212>  PRT
<213>  Homo sapiens

<400>  3440


Met Glu Asn Ala Gly His Pro Ser Ala Asp Thr Pro Thr Ala Thr Asn 
1               5                   10                  15      


Tyr Phe Leu Gln Tyr Ile Ser Ser Ser Leu Glu Asn Ser Thr Asn Ser 
            20                  25                  30          


Ala Asp Ala Ser Ser Asn Lys Phe Val Phe Gly Gln Asn Met Ser Glu 
        35                  40                  45              


Arg Val Leu Ser Pro Pro Lys Leu Asn Glu Val Ser Ser Asp Ala Asn 
    50                  55                  60                  


Arg Glu Asn Ala Ala Ala Glu Ser Gly Ser Glu Ser Ser Ser Gln Glu 
65                  70                  75                  80  


Ala Thr Pro Glu Lys Glu Ser Leu Ala Glu Ser Ala Ala Ala Tyr Thr 
                85                  90                  95      


Lys Ala Thr Ala Arg Lys Cys Leu Leu Glu Lys Val Glu Val Ile Thr 
            100                 105                 110         


Gly Glu Glu Ala Glu Ser Asn Val Leu Gln Met Gln Cys Lys Leu Phe 
        115                 120                 125             


Val Phe Asp Lys Thr Ser Gln Ser Trp Val Glu Arg Gly Arg Gly Leu 
    130                 135                 140                 


Leu Arg Leu Asn Asp Met Ala Ser Thr Asp Asp Gly Thr Leu Gln Ser 
145                 150                 155                 160 


Arg Leu Val Met Arg Thr Gln Gly Ser Leu Arg Leu Ile Leu Asn Thr 
                165                 170                 175     


Lys Leu Trp Ala Gln Met Gln Ile Asp Lys Ala Ser Glu Lys Ser Ile 
            180                 185                 190         


Arg Ile Thr Ala Met Asp Thr Glu Asp Gln Gly Val Lys Val Phe Leu 
        195                 200                 205             


Ile Ser Ala Ser Ser Lys Asp Thr Gly Gln Leu Tyr Ala Ala Leu His 
    210                 215                 220                 


His Arg Ile Leu Ala Leu Arg Ser Arg Val Glu Gln Glu Gln Glu Ala 
225                 230                 235                 240 


Lys Met Pro Ala Pro Glu Pro Gly Ala Ala Pro Ser Asn Glu Glu Asp 
                245                 250                 255     


Asp Ser Asp Asp Asp Asp Val Leu Ala Pro Ser Gly Ala Thr Ala Ala 
            260                 265                 270         


Gly Ala Gly Asp Glu Gly Asp Gly Gln Thr Thr Gly Ser Thr 
        275                 280                 285     

<210>  3441
<211>  3295
<212>  DNA
<213>  Homo sapiens

<400>  3441
aaggaagtaa aatggcggac ctggcgaacg aaggatgttg gtgtaagcca cctcctaagg     60

tggttgtgga gattaggtga catgatgcag ataaaaccta acacataaag aagtgctcga    120

agaacgctgg ccacgtatat gaaaccatca cgcgtctggg agaccccatt tgtggatgcc    180

tttgctgtgc atatcatggc agaaactaag ataagtctaa gagaaaagcc tgccattgct    240

ccgcccgtct ttgtgtttca gaaggataaa ggacaaaagt cccctgcaga gcaaaaaaac    300

ttgtcggatt cgggagagga gcctcggggg gaggctgagg ccccccacca tggcacgggt    360

caccccgagt cagctggcga gcatgcccta gaacctcctg cccctgctgg cgcctcagcc    420

agcactcctc cgcctcccgc tcctgaagcc cagcttcctc cttttccgcg agaactggca    480

gggaggtcag ctggcggctc cagtcctgaa ggcggagaag attctgacag agaagatgga    540

aattactgcc ctcctgtcaa gcgagaaaga acatcctctt taacccagtt cccaccctca    600

cagtcagagg aaaggagcag tggcttccgg ttgaagccac caacgctgat ccacggccaa    660

gcccccagcg caggtctgcc aagccagaag cccaaggagc agcagcggag cgtgcttcgc    720

ccggcagtgt tacaagctcc gcagccaaag gcgctgtccc agactgtccc cagcagtggc    780

accaacgggg tcagcctccc agcagactgc acgggggcag tgcccgcagc atcccctgac    840

actgctgcat ggagaagtcc ttccgaagct gccgatgagg tgtgtgcact tgaggagaaa    900

gagccccaga aaaatgagtc cagcaatgcc tctgaagagg aagcctgtga gaaaaaagac    960

cccgccacac agcaagcctt tgtatttggg cagaacttga gggacagagt taagctgata   1020

aatgagagcg tggacgaagc cgacatggag aatgctggac accccagcgc agacacgcca   1080

accgcaacga actatttcct ccagtatatc agttccagtt tagagaactc aaccaatagt   1140

gccgacgcct ccagcaacaa atttgtattt ggccagaaca tgagcgagcg agttttgagc   1200

cccccaaaat taaacgaggt cagttcagat gccaacaggg aaaatgcagc tgccgagtca   1260

gggtctgagt cctcgtccca ggaggccacc cctgagaaag agtccctggc tgagtcggca   1320

gccgcctaca ccaaggcaac agcgcggaag tgtttgttgg aaaaagtgga agtcatcacc   1380

ggggaggagg cggagagcaa tgtgttacag atgcagtgca agctgtttgt ctttgacaag   1440

acctcacagt cctgggtgga gagaggccgg gggctgctca gactcaatga catggcgtcc   1500

accgatgacg gcacactaca gtcccgacta gtgatgcgga cccaggggag cctgcgactg   1560

atcctcaaca ccaagctgtg ggcccagatg cagatcgaca aggccagcga gaagagcatt   1620

cgcatcacag ccatggacac cgaggaccag ggcgtgaagg tcttcctgat ctcggccagc   1680

tccaaggaca caggtcagtt gtatgcagcc ctgcaccacc gcatcctggc cctgcgcagc   1740

cgcgtggagc aggagcagga ggccaagatg cccgcgcctg agcctggggc agccccatcc   1800

aacgaggagg acgacagcga cgatgacgat gtcctggctc cttcaggggc caccgcagct   1860

ggtgctggtg acgaagggga cgggcagacg accgggagca catagcggcc gggagcccgg   1920

ctgcacacca ggctgctgct ttgtccgtct atccacccgc ccacccgccc ccaccccacc   1980

ggcagcgtcc aggtgcgggg ccgggaacca cacaccccac tgggccggcc acagtctgga   2040

cccgcacgtc ctgttcaaaa gcagactcgg gaactgcctg aatgtggttt gggacacgag   2100

acctcatcat attgatgagc gaacgacctc gttccttcac cccgcgtgtc gccagcctct   2160

gggtccagcc agagcccctg gcttctccgc cacccacacc cttcccaccc tgctgtgggg   2220

ccctgccttt gtggggagca gccagccctc tgcccctgcc cagggctccc caactatagg   2280

cctgggaccc ccgcccagct tggggggctg ctcgtacgag tgtagacact gggcccattg   2340

gacgtgctgt taactactat cttcatttcc cacttcccct ctctgattgg gggtgtatat   2400

tttacatctt tttttctttt tattttcgaa ggctttgttt tggtttctta ggttaagatg   2460

ctctcgagcg ttgagcaggc acagctctgt cgaggtccct gtcccccacc tgtggttctg   2520

gcctctgagg ttgggggact acttgtttcc caccccaggt tcctccaggc caagtcatgg   2580

ggtgatgagg agttggggcc ctgtctgtcc taggcctgga gagtgcctgt ctgggaaaag   2640

gtcactggac ctggaagggt ccccagggtc ccctgactcc cgtctccatc tgtcacgtgg   2700

ttcaccatca tcaggcacca ggcgcaaact gcttcccgct gttggccatc ccttccccag   2760

ccacaggtgt ccctgccccc aggacagtcc agggccaggg gcttctgtga gaggcagagg   2820

gggaccctca ccaaatcttg gtggaagagc ccaggggctg gtcccagaac aggcagtctc   2880

acaagcacgc agcacactgg agtggacgcc tgtgcccacc cgagcctgga gcatggccaa   2940

gagccagctt gcaccaccca cctgggaggc cgaggaggag gtcccctggg cacagggcct   3000

ctttgggact tcagaggaaa tctcccagtc ccactctcgg agggttaaga gaaggcctcc   3060

tgcagctgtg ccgtccacac ctctaggtcg ccagagccct ggcccccagc ccccagcaag   3120

cctgagcccg ggaagaacca gaggccctcc cgagagaccc agtcacacgt ctctgcttta   3180

agccttagcc agctagtgac gagtacaacg agataacgcc catgtgtttt ggaacattta   3240

tgtaagattg tcatatgaaa tgtatttggg aactacatta aacttttaac taaaa        3295


<210>  3442
<211>  588
<212>  PRT
<213>  Homo sapiens

<400>  3442


Met Lys Pro Ser Arg Val Trp Glu Thr Pro Phe Val Asp Ala Phe Ala 
1               5                   10                  15      


Val His Ile Met Ala Glu Thr Lys Ile Ser Leu Arg Glu Lys Pro Ala 
            20                  25                  30          


Ile Ala Pro Pro Val Phe Val Phe Gln Lys Asp Lys Gly Gln Lys Ser 
        35                  40                  45              


Pro Ala Glu Gln Lys Asn Leu Ser Asp Ser Gly Glu Glu Pro Arg Gly 
    50                  55                  60                  


Glu Ala Glu Ala Pro His His Gly Thr Gly His Pro Glu Ser Ala Gly 
65                  70                  75                  80  


Glu His Ala Leu Glu Pro Pro Ala Pro Ala Gly Ala Ser Ala Ser Thr 
                85                  90                  95      


Pro Pro Pro Pro Ala Pro Glu Ala Gln Leu Pro Pro Phe Pro Arg Glu 
            100                 105                 110         


Leu Ala Gly Arg Ser Ala Gly Gly Ser Ser Pro Glu Gly Gly Glu Asp 
        115                 120                 125             


Ser Asp Arg Glu Asp Gly Asn Tyr Cys Pro Pro Val Lys Arg Glu Arg 
    130                 135                 140                 


Thr Ser Ser Leu Thr Gln Phe Pro Pro Ser Gln Ser Glu Glu Arg Ser 
145                 150                 155                 160 


Ser Gly Phe Arg Leu Lys Pro Pro Thr Leu Ile His Gly Gln Ala Pro 
                165                 170                 175     


Ser Ala Gly Leu Pro Ser Gln Lys Pro Lys Glu Gln Gln Arg Ser Val 
            180                 185                 190         


Leu Arg Pro Ala Val Leu Gln Ala Pro Gln Pro Lys Ala Leu Ser Gln 
        195                 200                 205             


Thr Val Pro Ser Ser Gly Thr Asn Gly Val Ser Leu Pro Ala Asp Cys 
    210                 215                 220                 


Thr Gly Ala Val Pro Ala Ala Ser Pro Asp Thr Ala Ala Trp Arg Ser 
225                 230                 235                 240 


Pro Ser Glu Ala Ala Asp Glu Val Cys Ala Leu Glu Glu Lys Glu Pro 
                245                 250                 255     


Gln Lys Asn Glu Ser Ser Asn Ala Ser Glu Glu Glu Ala Cys Glu Lys 
            260                 265                 270         


Lys Asp Pro Ala Thr Gln Gln Ala Phe Val Phe Gly Gln Asn Leu Arg 
        275                 280                 285             


Asp Arg Val Lys Leu Ile Asn Glu Ser Val Asp Glu Ala Asp Met Glu 
    290                 295                 300                 


Asn Ala Gly His Pro Ser Ala Asp Thr Pro Thr Ala Thr Asn Tyr Phe 
305                 310                 315                 320 


Leu Gln Tyr Ile Ser Ser Ser Leu Glu Asn Ser Thr Asn Ser Ala Asp 
                325                 330                 335     


Ala Ser Ser Asn Lys Phe Val Phe Gly Gln Asn Met Ser Glu Arg Val 
            340                 345                 350         


Leu Ser Pro Pro Lys Leu Asn Glu Val Ser Ser Asp Ala Asn Arg Glu 
        355                 360                 365             


Asn Ala Ala Ala Glu Ser Gly Ser Glu Ser Ser Ser Gln Glu Ala Thr 
    370                 375                 380                 


Pro Glu Lys Glu Ser Leu Ala Glu Ser Ala Ala Ala Tyr Thr Lys Ala 
385                 390                 395                 400 


Thr Ala Arg Lys Cys Leu Leu Glu Lys Val Glu Val Ile Thr Gly Glu 
                405                 410                 415     


Glu Ala Glu Ser Asn Val Leu Gln Met Gln Cys Lys Leu Phe Val Phe 
            420                 425                 430         


Asp Lys Thr Ser Gln Ser Trp Val Glu Arg Gly Arg Gly Leu Leu Arg 
        435                 440                 445             


Leu Asn Asp Met Ala Ser Thr Asp Asp Gly Thr Leu Gln Ser Arg Leu 
    450                 455                 460                 


Val Met Arg Thr Gln Gly Ser Leu Arg Leu Ile Leu Asn Thr Lys Leu 
465                 470                 475                 480 


Trp Ala Gln Met Gln Ile Asp Lys Ala Ser Glu Lys Ser Ile Arg Ile 
                485                 490                 495     


Thr Ala Met Asp Thr Glu Asp Gln Gly Val Lys Val Phe Leu Ile Ser 
            500                 505                 510         


Ala Ser Ser Lys Asp Thr Gly Gln Leu Tyr Ala Ala Leu His His Arg 
        515                 520                 525             


Ile Leu Ala Leu Arg Ser Arg Val Glu Gln Glu Gln Glu Ala Lys Met 
    530                 535                 540                 


Pro Ala Pro Glu Pro Gly Ala Ala Pro Ser Asn Glu Glu Asp Asp Ser 
545                 550                 555                 560 


Asp Asp Asp Asp Val Leu Ala Pro Ser Gly Ala Thr Ala Ala Gly Ala 
                565                 570                 575     


Gly Asp Glu Gly Asp Gly Gln Thr Thr Gly Ser Thr 
            580                 585             

<210>  3443
<211>  2836
<212>  DNA
<213>  Homo sapiens

<400>  3443
gcctgggccg gcgcggggcc ttgtgggagg gcttaaggaa gtaaaatggc ggacctggcg     60

aacgaagagg aaaggagcag tggcttccgg ttgaagccac caacgctgat ccacggccaa    120

gcccccagcg caggtctgcc aagccagaag cccaaggagc agcagcggag cgtgcttcgc    180

ccggcagtgt tacaagctcc gcagccaaag gcgctgtccc agactgtccc cagcagtggc    240

accaacgggg tcagcctccc agcagactgc acgggggcag tgcccgcagc atcccctgac    300

actgctgcat ggagaagtcc ttccgaagct gccgatgagg tgtgtgcact tgaggagaaa    360

gagccccaga aaaatgagtc cagcaatgcc tctgaagagg aagcctgtga gaaaaaagac    420

cccgccacac agcaagcctt tgtatttggg cagaacttga gggacagagt taagctgata    480

aatgagagcg tggacgaagc cgacatggag aatgctggac accccagcgc agacacgcca    540

accgcaacga actatttcct ccagtatatc agttccagtt tagagaactc aaccaatagt    600

gccgacgcct ccagcaacaa atttgtattt ggccagaaca tgagcgagcg agttttgagc    660

cccccaaaat taaacgaggt cagttcagat gccaacaggg aaaatgcagc tgccgagtca    720

gggtctgagt cctcgtccca ggaggccacc cctgagaaag agtccctggc tgagtcggca    780

gccgcctaca ccaaggcaac agcgcggaag tgtttgttgg aaaaagtgga agtcatcacc    840

ggggaggagg cggagagcaa tgtgttacag atgcagtgca agctgtttgt ctttgacaag    900

acctcacagt cctgggtgga gagaggccgg gggctgctca gactcaatga catggcgtcc    960

accgatgacg gcacactaca gtcccgacta gtgatgcgga cccaggggag cctgcgactg   1020

atcctcaaca ccaagctgtg ggcccagatg cagatcgaca aggccagcga gaagagcatt   1080

cgcatcacag ccatggacac cgaggaccag ggcgtgaagg tcttcctgat ctcggccagc   1140

tccaaggaca caggtcagtt gtatgcagcc ctgcaccacc gcatcctggc cctgcgcagc   1200

cgcgtggagc aggagcagga ggccaagatg cccgcgcctg agcctggggc agccccatcc   1260

aacgaggagg acgacagcga cgatgacgat gtcctggctc cttcaggggc caccgcagct   1320

ggtgctggtg acgaagggga cgggcagacg accgggagca catagcggcc gggagcccgg   1380

ctgcacacca ggctgctgct ttgtccgtct atccacccgc ccacccgccc ccaccccacc   1440

ggcagcgtcc aggtgcgggg ccgggaacca cacaccccac tgggccggcc acagtctgga   1500

cccgcacgtc ctgttcaaaa gcagactcgg gaactgcctg aatgtggttt gggacacgag   1560

acctcatcat attgatgagc gaacaaacaa gaacatttcc tccctcccct cctttgaatt   1620

gaaatggcac attaagactt gtcacggctt ctcactggga ctggagacct cgttccttca   1680

ccccgcgtgt cgccagcctc tgggtccagc cagagcccct ggcttctccg ccacccacac   1740

ccttcccacc ctgctgtggg gccctgcctt tgtggggagc agccagccct ctgcccctgc   1800

ccagggctcc ccaactatag gcctgggacc cccgcccagc ttggggggct gctcgtacga   1860

gtgtagacac tgggcccatt ggacgtgctg ttaactacta tcttcatttc ccacttcccc   1920

tctctgattg ggggtgtata ttttacatct ttttttcttt ttattttcga aggctttgtt   1980

ttggtttctt aggttaagat gctctcgagc gttgagcagg cacagctctg tcgaggtccc   2040

tgtcccccac ctgtggttct ggcctctgag gttgggggac tacttgtttc ccaccccagg   2100

ttcctccagg ccaagtcatg gggtgatgag gagttggggc cctgtctgtc ctaggcctgg   2160

agagtgcctg tctgggaaaa ggtcactgga cctggaaggg tccccagggt cccctgactc   2220

ccgtctccat ctgtcacgtg gttcaccatc atcaggcacc aggcgcaaac tgcttcccgc   2280

tgttggccat cccttcccca gccacaggtg tccctgcccc caggacagtc cagggccagg   2340

ggcttctgtg agaggcagag ggggaccctc accaaatctt ggtggaagag cccaggggct   2400

ggtcccagaa caggcagtct cacaagcacg cagcacactg gagtggacgc ctgtgcccac   2460

ccgagcctgg agcatggcca agagccagct tgcaccaccc acctgggagg ccgaggagga   2520

ggtcccctgg gcacagggcc tctttgggac ttcagaggaa atctcccagt cccactctcg   2580

gagggttaag agaaggcctc ctgcagctgt gccgtccaca cctctaggtc gccagagccc   2640

tggcccccag cccccagcaa gcctgagccc gggaagaacc agaggccctc ccgagagacc   2700

cagtcacacg tctctgcttt aagccttagc cagctagtga cgagtacaac gagataacgc   2760

ccatgtgttt tggaacattt atgtaagatt gtcatatgaa atgtatttgg gaactacatt   2820

aaacttttaa ctaaaa                                                   2836


<210>  3444
<211>  439
<212>  PRT
<213>  Homo sapiens

<400>  3444


Met Ala Asp Leu Ala Asn Glu Glu Glu Arg Ser Ser Gly Phe Arg Leu 
1               5                   10                  15      


Lys Pro Pro Thr Leu Ile His Gly Gln Ala Pro Ser Ala Gly Leu Pro 
            20                  25                  30          


Ser Gln Lys Pro Lys Glu Gln Gln Arg Ser Val Leu Arg Pro Ala Val 
        35                  40                  45              


Leu Gln Ala Pro Gln Pro Lys Ala Leu Ser Gln Thr Val Pro Ser Ser 
    50                  55                  60                  


Gly Thr Asn Gly Val Ser Leu Pro Ala Asp Cys Thr Gly Ala Val Pro 
65                  70                  75                  80  


Ala Ala Ser Pro Asp Thr Ala Ala Trp Arg Ser Pro Ser Glu Ala Ala 
                85                  90                  95      


Asp Glu Val Cys Ala Leu Glu Glu Lys Glu Pro Gln Lys Asn Glu Ser 
            100                 105                 110         


Ser Asn Ala Ser Glu Glu Glu Ala Cys Glu Lys Lys Asp Pro Ala Thr 
        115                 120                 125             


Gln Gln Ala Phe Val Phe Gly Gln Asn Leu Arg Asp Arg Val Lys Leu 
    130                 135                 140                 


Ile Asn Glu Ser Val Asp Glu Ala Asp Met Glu Asn Ala Gly His Pro 
145                 150                 155                 160 


Ser Ala Asp Thr Pro Thr Ala Thr Asn Tyr Phe Leu Gln Tyr Ile Ser 
                165                 170                 175     


Ser Ser Leu Glu Asn Ser Thr Asn Ser Ala Asp Ala Ser Ser Asn Lys 
            180                 185                 190         


Phe Val Phe Gly Gln Asn Met Ser Glu Arg Val Leu Ser Pro Pro Lys 
        195                 200                 205             


Leu Asn Glu Val Ser Ser Asp Ala Asn Arg Glu Asn Ala Ala Ala Glu 
    210                 215                 220                 


Ser Gly Ser Glu Ser Ser Ser Gln Glu Ala Thr Pro Glu Lys Glu Ser 
225                 230                 235                 240 


Leu Ala Glu Ser Ala Ala Ala Tyr Thr Lys Ala Thr Ala Arg Lys Cys 
                245                 250                 255     


Leu Leu Glu Lys Val Glu Val Ile Thr Gly Glu Glu Ala Glu Ser Asn 
            260                 265                 270         


Val Leu Gln Met Gln Cys Lys Leu Phe Val Phe Asp Lys Thr Ser Gln 
        275                 280                 285             


Ser Trp Val Glu Arg Gly Arg Gly Leu Leu Arg Leu Asn Asp Met Ala 
    290                 295                 300                 


Ser Thr Asp Asp Gly Thr Leu Gln Ser Arg Leu Val Met Arg Thr Gln 
305                 310                 315                 320 


Gly Ser Leu Arg Leu Ile Leu Asn Thr Lys Leu Trp Ala Gln Met Gln 
                325                 330                 335     


Ile Asp Lys Ala Ser Glu Lys Ser Ile Arg Ile Thr Ala Met Asp Thr 
            340                 345                 350         


Glu Asp Gln Gly Val Lys Val Phe Leu Ile Ser Ala Ser Ser Lys Asp 
        355                 360                 365             


Thr Gly Gln Leu Tyr Ala Ala Leu His His Arg Ile Leu Ala Leu Arg 
    370                 375                 380                 


Ser Arg Val Glu Gln Glu Gln Glu Ala Lys Met Pro Ala Pro Glu Pro 
385                 390                 395                 400 


Gly Ala Ala Pro Ser Asn Glu Glu Asp Asp Ser Asp Asp Asp Asp Val 
                405                 410                 415     


Leu Ala Pro Ser Gly Ala Thr Ala Ala Gly Ala Gly Asp Glu Gly Asp 
            420                 425                 430         


Gly Gln Thr Thr Gly Ser Thr 
        435                 

<210>  3445
<211>  3152
<212>  DNA
<213>  Homo sapiens

<400>  3445
agaaagcagg cgagcctggg ccggcgcggg gccttgtggg agggcttaag gaagtaaaat     60

ggcggacctg gcgaacgaag aaaagcctgc cattgctccg cccgtctttg tgtttcagaa    120

ggataaagga caaaagtccc ctgcagagca aaaaaacttg tcggattcgg gagaggagcc    180

tcggggggag gctgaggccc cccaccatgg cacgggtcac cccgagtcag ctggcgagca    240

tgccctagaa cctcctgccc ctgctggcgc ctcagccagc actcctccgc ctcccgctcc    300

tgaagcccag cttcctcctt ttccgcgaga actggcaggg aggtcagctg gcggctccag    360

tcctgaaggc ggagaagatt ctgacagaga agatggaaat tactgccctc ctgtcaagcg    420

agaaagaaca tcctctttaa cccagttccc accctcacag tcagaggaaa ggagcagtgg    480

cttccggttg aagccaccaa cgctgatcca cggccaagcc cccagcgcag gtctgccaag    540

ccagaagccc aaggagcagc agcggagcgt gcttcgcccg gcagtgttac aagctccgca    600

gccaaaggcg ctgtcccaga ctgtccccag cagtggcacc aacggggtca gcctcccagc    660

agactgcacg ggggcagtgc ccgcagcatc ccctgacact gctgcatgga gaagtccttc    720

cgaagctgcc gatgaggtgt gtgcacttga ggagaaagag ccccagaaaa atgagtccag    780

caatgcctct gaagaggaag cctgtgagaa aaaagacccc gccacacagc aagcctttgt    840

atttgggcag aacttgaggg acagagttaa gctgataaat gagagcgtgg acgaagccga    900

catggagaat gctggacacc ccagcgcaga cacgccaacc gcaacgaact atttcctcca    960

gtatatcagt tccagtttag agaactcaac caatagtgcc gacgcctcca gcaacaaatt   1020

tgtatttggc cagaacatga gcgagcgagt tttgagcccc ccaaaattaa acgaggtcag   1080

ttcagatgcc aacagggaaa atgcagctgc cgagtcaggg tctgagtcct cgtcccagga   1140

ggccacccct gagaaagagt ccctggctga gtcggcagcc gcctacacca aggcaacagc   1200

gcggaagtgt ttgttggaaa aagtggaagt catcaccggg gaggaggcgg agagcaatgt   1260

gttacagatg cagtgcaagc tgtttgtctt tgacaagacc tcacagtcct gggtggagag   1320

aggccggggg ctgctcagac tcaatgacat ggcgtccacc gatgacggca cactacagtc   1380

ccgactagtg atgcggaccc aggggagcct gcgactgatc ctcaacacca agctgtgggc   1440

ccagatgcag atcgacaagg ccagcgagaa gagcattcgc atcacagcca tggacaccga   1500

ggaccagggc gtgaaggtct tcctgatctc ggccagctcc aaggacacag gtcagttgta   1560

tgcagccctg caccaccgca tcctggccct gcgcagccgc gtggagcagg agcaggaggc   1620

caagatgccc gcgcctgagc ctggggcagc cccatccaac gaggaggacg acagcgacga   1680

tgacgatgtc ctggctcctt caggggccac cgcagctggt gctggtgacg aaggggacgg   1740

gcagacgacc gggagcacat agcggccggg agcccggctg cacaccaggc tgctgctttg   1800

tccgtctatc cacccgccca cccgccccca ccccaccggc agcgtccagg tgcggggccg   1860

ggaaccacac accccactgg gccggccaca gtctggaccc gcacgtcctg ttcaaaagca   1920

gactcgggaa ctgcctgaat gtggtttggg acacgagacc tcatcatatt gatgagcgaa   1980

cgacctcgtt ccttcacccc gcgtgtcgcc agcctctggg tccagccaga gcccctggct   2040

tctccgccac ccacaccctt cccaccctgc tgtggggccc tgcctttgtg gggagcagcc   2100

agccctctgc ccctgcccag ggctccccaa ctataggcct gggacccccg cccagcttgg   2160

ggggctgctc gtacgagtgt agacactggg cccattggac gtgctgttaa ctactatctt   2220

catttcccac ttcccctctc tgattggggg tgtatatttt acatcttttt ttctttttat   2280

tttcgaaggc tttgttttgg tttcttaggt taagatgctc tcgagcgttg agcaggcaca   2340

gctctgtcga ggtccctgtc ccccacctgt ggttctggcc tctgaggttg ggggactact   2400

tgtttcccac cccaggttcc tccaggccaa gtcatggggt gatgaggagt tggggccctg   2460

tctgtcctag gcctggagag tgcctgtctg ggaaaaggtc actggacctg gaagggtccc   2520

cagggtcccc tgactcccgt ctccatctgt cacgtggttc accatcatca ggcaccaggc   2580

gcaaactgct tcccgctgtt ggccatccct tccccagcca caggtgtccc tgcccccagg   2640

acagtccagg gccaggggct tctgtgagag gcagaggggg accctcacca aatcttggtg   2700

gaagagccca ggggctggtc ccagaacagg cagtctcaca agcacgcagc acactggagt   2760

ggacgcctgt gcccacccga gcctggagca tggccaagag ccagcttgca ccacccacct   2820

gggaggccga ggaggaggtc ccctgggcac agggcctctt tgggacttca gaggaaatct   2880

cccagtccca ctctcggagg gttaagagaa ggcctcctgc agctgtgccg tccacacctc   2940

taggtcgcca gagccctggc ccccagcccc cagcaagcct gagcccggga agaaccagag   3000

gccctcccga gagacccagt cacacgtctc tgctttaagc cttagccagc tagtgacgag   3060

tacaacgaga taacgcccat gtgttttgga acatttatgt aagattgtca tatgaaatgt   3120

atttgggaac tacattaaac ttttaactaa aa                                 3152


<210>  3446
<211>  567
<212>  PRT
<213>  Homo sapiens

<400>  3446


Met Ala Asp Leu Ala Asn Glu Glu Lys Pro Ala Ile Ala Pro Pro Val 
1               5                   10                  15      


Phe Val Phe Gln Lys Asp Lys Gly Gln Lys Ser Pro Ala Glu Gln Lys 
            20                  25                  30          


Asn Leu Ser Asp Ser Gly Glu Glu Pro Arg Gly Glu Ala Glu Ala Pro 
        35                  40                  45              


His His Gly Thr Gly His Pro Glu Ser Ala Gly Glu His Ala Leu Glu 
    50                  55                  60                  


Pro Pro Ala Pro Ala Gly Ala Ser Ala Ser Thr Pro Pro Pro Pro Ala 
65                  70                  75                  80  


Pro Glu Ala Gln Leu Pro Pro Phe Pro Arg Glu Leu Ala Gly Arg Ser 
                85                  90                  95      


Ala Gly Gly Ser Ser Pro Glu Gly Gly Glu Asp Ser Asp Arg Glu Asp 
            100                 105                 110         


Gly Asn Tyr Cys Pro Pro Val Lys Arg Glu Arg Thr Ser Ser Leu Thr 
        115                 120                 125             


Gln Phe Pro Pro Ser Gln Ser Glu Glu Arg Ser Ser Gly Phe Arg Leu 
    130                 135                 140                 


Lys Pro Pro Thr Leu Ile His Gly Gln Ala Pro Ser Ala Gly Leu Pro 
145                 150                 155                 160 


Ser Gln Lys Pro Lys Glu Gln Gln Arg Ser Val Leu Arg Pro Ala Val 
                165                 170                 175     


Leu Gln Ala Pro Gln Pro Lys Ala Leu Ser Gln Thr Val Pro Ser Ser 
            180                 185                 190         


Gly Thr Asn Gly Val Ser Leu Pro Ala Asp Cys Thr Gly Ala Val Pro 
        195                 200                 205             


Ala Ala Ser Pro Asp Thr Ala Ala Trp Arg Ser Pro Ser Glu Ala Ala 
    210                 215                 220                 


Asp Glu Val Cys Ala Leu Glu Glu Lys Glu Pro Gln Lys Asn Glu Ser 
225                 230                 235                 240 


Ser Asn Ala Ser Glu Glu Glu Ala Cys Glu Lys Lys Asp Pro Ala Thr 
                245                 250                 255     


Gln Gln Ala Phe Val Phe Gly Gln Asn Leu Arg Asp Arg Val Lys Leu 
            260                 265                 270         


Ile Asn Glu Ser Val Asp Glu Ala Asp Met Glu Asn Ala Gly His Pro 
        275                 280                 285             


Ser Ala Asp Thr Pro Thr Ala Thr Asn Tyr Phe Leu Gln Tyr Ile Ser 
    290                 295                 300                 


Ser Ser Leu Glu Asn Ser Thr Asn Ser Ala Asp Ala Ser Ser Asn Lys 
305                 310                 315                 320 


Phe Val Phe Gly Gln Asn Met Ser Glu Arg Val Leu Ser Pro Pro Lys 
                325                 330                 335     


Leu Asn Glu Val Ser Ser Asp Ala Asn Arg Glu Asn Ala Ala Ala Glu 
            340                 345                 350         


Ser Gly Ser Glu Ser Ser Ser Gln Glu Ala Thr Pro Glu Lys Glu Ser 
        355                 360                 365             


Leu Ala Glu Ser Ala Ala Ala Tyr Thr Lys Ala Thr Ala Arg Lys Cys 
    370                 375                 380                 


Leu Leu Glu Lys Val Glu Val Ile Thr Gly Glu Glu Ala Glu Ser Asn 
385                 390                 395                 400 


Val Leu Gln Met Gln Cys Lys Leu Phe Val Phe Asp Lys Thr Ser Gln 
                405                 410                 415     


Ser Trp Val Glu Arg Gly Arg Gly Leu Leu Arg Leu Asn Asp Met Ala 
            420                 425                 430         


Ser Thr Asp Asp Gly Thr Leu Gln Ser Arg Leu Val Met Arg Thr Gln 
        435                 440                 445             


Gly Ser Leu Arg Leu Ile Leu Asn Thr Lys Leu Trp Ala Gln Met Gln 
    450                 455                 460                 


Ile Asp Lys Ala Ser Glu Lys Ser Ile Arg Ile Thr Ala Met Asp Thr 
465                 470                 475                 480 


Glu Asp Gln Gly Val Lys Val Phe Leu Ile Ser Ala Ser Ser Lys Asp 
                485                 490                 495     


Thr Gly Gln Leu Tyr Ala Ala Leu His His Arg Ile Leu Ala Leu Arg 
            500                 505                 510         


Ser Arg Val Glu Gln Glu Gln Glu Ala Lys Met Pro Ala Pro Glu Pro 
        515                 520                 525             


Gly Ala Ala Pro Ser Asn Glu Glu Asp Asp Ser Asp Asp Asp Asp Val 
    530                 535                 540                 


Leu Ala Pro Ser Gly Ala Thr Ala Ala Gly Ala Gly Asp Glu Gly Asp 
545                 550                 555                 560 


Gly Gln Thr Thr Gly Ser Thr 
                565         

<210>  3447
<211>  3233
<212>  DNA
<213>  Homo sapiens

<400>  3447
agaaagcagg cgagcctggg ccggcgcggg gccttgtggg agggcttaag gaagtaaaat     60

ggcggacctg gcgaacgaag aaaagcctgc cattgctccg cccgtctttg tgtttcagaa    120

ggataaagga caaaagtccc ctgcagagca aaaaaacttg tcggattcgg gagaggagcc    180

tcggggggag gctgaggccc cccaccatgg cacgggtcac cccgagtcag ctggcgagca    240

tgccctagaa cctcctgccc ctgctggcgc ctcagccagc actcctccgc ctcccgctcc    300

tgaagcccag cttcctcctt ttccgcgaga actggcaggg aggtcagctg gcggctccag    360

tcctgaaggc ggagaagatt ctgacagaga agatggaaat tactgccctc ctgtcaagcg    420

agaaagaaca tcctctttaa cccagttccc accctcacag tcagaggaaa ggagcagtgg    480

cttccggttg aagccaccaa cgctgatcca cggccaagcc cccagcgcag gtctgccaag    540

ccagaagccc aaggagcagc agcggagcgt gcttcgcccg gcagtgttac aagctccgca    600

gccaaaggcg ctgtcccaga ctgtccccag cagtggcacc aacggggtca gcctcccagc    660

agactgcacg ggggcagtgc ccgcagcatc ccctgacact gctgcatgga gaagtccttc    720

cgaagctgcc gatgaggtgt gtgcacttga ggagaaagag ccccagaaaa atgagtccag    780

caatgcctct gaagaggaag cctgtgagaa aaaagacccc gccacacagc aagcctttgt    840

atttgggcag aacttgaggg acagagttaa gctgataaat gagagcgtgg acgaagccga    900

catggagaat gctggacacc ccagcgcaga cacgccaacc gcaacgaact atttcctcca    960

gtatatcagt tccagtttag agaactcaac caatagtgcc gacgcctcca gcaacaaatt   1020

tgtatttggc cagaacatga gcgagcgagt tttgagcccc ccaaaattaa acgaggtcag   1080

ttcagatgcc aacagggaaa atgcagctgc cgagtcaggg tctgagtcct cgtcccagga   1140

ggccacccct gagaaagagt ccctggctga gtcggcagcc gcctacacca aggcaacagc   1200

gcggaagtgt ttgttggaaa aagtggaagt catcaccggg gaggaggcgg agagcaatgt   1260

gttacagatg cagtgcaagc tgtttgtctt tgacaagacc tcacagtcct gggtggagag   1320

aggccggggg ctgctcagac tcaatgacat ggcgtccacc gatgacggca cactacagtc   1380

ccgactagtg atgcggaccc aggggagcct gcgactgatc ctcaacacca agctgtgggc   1440

ccagatgcag atcgacaagg ccagcgagaa gagcattcgc atcacagcca tggacaccga   1500

ggaccagggc gtgaaggtct tcctgatctc ggccagctcc aaggacacag gtcagttgta   1560

tgcagccctg caccaccgca tcctggccct gcgcagccgc gtggagcagg agcaggaggc   1620

caagatgccc gcgcctgagc ctggggcagc cccatccaac gaggaggacg acagcgacga   1680

tgacgatgtc ctggctcctt caggggccac cgcagctggt gctggtgacg aaggggacgg   1740

gcagacgacc gggagcacat agcggccggg agcccggctg cacaccaggc tgctgctttg   1800

tccgtctatc cacccgccca cccgccccca ccccaccggc agcgtccagg tgcggggccg   1860

ggaaccacac accccactgg gccggccaca gtctggaccc gcacgtcctg ttcaaaagca   1920

gactcgggaa ctgcctgaat gtggtttggg acacgagacc tcatcatatt gatgagcgaa   1980

caaacaagaa catttcctcc ctcccctcct ttgaattgaa atggcacatt aagacttgtc   2040

acggcttctc actgggactg gagacctcgt tccttcaccc cgcgtgtcgc cagcctctgg   2100

gtccagccag agcccctggc ttctccgcca cccacaccct tcccaccctg ctgtggggcc   2160

ctgcctttgt ggggagcagc cagccctctg cccctgccca gggctcccca actataggcc   2220

tgggaccccc gcccagcttg gggggctgct cgtacgagtg tagacactgg gcccattgga   2280

cgtgctgtta actactatct tcatttccca cttcccctct ctgattgggg gtgtatattt   2340

tacatctttt tttcttttta ttttcgaagg ctttgttttg gtttcttagg ttaagatgct   2400

ctcgagcgtt gagcaggcac agctctgtcg aggtccctgt cccccacctg tggttctggc   2460

ctctgaggtt gggggactac ttgtttccca ccccaggttc ctccaggcca agtcatgggg   2520

tgatgaggag ttggggccct gtctgtccta ggcctggaga gtgcctgtct gggaaaaggt   2580

cactggacct ggaagggtcc ccagggtccc ctgactcccg tctccatctg tcacgtggtt   2640

caccatcatc aggcaccagg cgcaaactgc ttcccgctgt tggccatccc ttccccagcc   2700

acaggtgtcc ctgcccccag gacagtccag ggccaggggc ttctgtgaga ggcagagggg   2760

gaccctcacc aaatcttggt ggaagagccc aggggctggt cccagaacag gcagtctcac   2820

aagcacgcag cacactggag tggacgcctg tgcccacccg agcctggagc atggccaaga   2880

gccagcttgc accacccacc tgggaggccg aggaggaggt cccctgggca cagggcctct   2940

ttgggacttc agaggaaatc tcccagtccc actctcggag ggttaagaga aggcctcctg   3000

cagctgtgcc gtccacacct ctaggtcgcc agagccctgg cccccagccc ccagcaagcc   3060

tgagcccggg aagaaccaga ggccctcccg agagacccag tcacacgtct ctgctttaag   3120

ccttagccag ctagtgacga gtacaacgag ataacgccca tgtgttttgg aacatttatg   3180

taagattgtc atatgaaatg tatttgggaa ctacattaaa cttttaacta aaa          3233


<210>  3448
<211>  567
<212>  PRT
<213>  Homo sapiens

<400>  3448


Met Ala Asp Leu Ala Asn Glu Glu Lys Pro Ala Ile Ala Pro Pro Val 
1               5                   10                  15      


Phe Val Phe Gln Lys Asp Lys Gly Gln Lys Ser Pro Ala Glu Gln Lys 
            20                  25                  30          


Asn Leu Ser Asp Ser Gly Glu Glu Pro Arg Gly Glu Ala Glu Ala Pro 
        35                  40                  45              


His His Gly Thr Gly His Pro Glu Ser Ala Gly Glu His Ala Leu Glu 
    50                  55                  60                  


Pro Pro Ala Pro Ala Gly Ala Ser Ala Ser Thr Pro Pro Pro Pro Ala 
65                  70                  75                  80  


Pro Glu Ala Gln Leu Pro Pro Phe Pro Arg Glu Leu Ala Gly Arg Ser 
                85                  90                  95      


Ala Gly Gly Ser Ser Pro Glu Gly Gly Glu Asp Ser Asp Arg Glu Asp 
            100                 105                 110         


Gly Asn Tyr Cys Pro Pro Val Lys Arg Glu Arg Thr Ser Ser Leu Thr 
        115                 120                 125             


Gln Phe Pro Pro Ser Gln Ser Glu Glu Arg Ser Ser Gly Phe Arg Leu 
    130                 135                 140                 


Lys Pro Pro Thr Leu Ile His Gly Gln Ala Pro Ser Ala Gly Leu Pro 
145                 150                 155                 160 


Ser Gln Lys Pro Lys Glu Gln Gln Arg Ser Val Leu Arg Pro Ala Val 
                165                 170                 175     


Leu Gln Ala Pro Gln Pro Lys Ala Leu Ser Gln Thr Val Pro Ser Ser 
            180                 185                 190         


Gly Thr Asn Gly Val Ser Leu Pro Ala Asp Cys Thr Gly Ala Val Pro 
        195                 200                 205             


Ala Ala Ser Pro Asp Thr Ala Ala Trp Arg Ser Pro Ser Glu Ala Ala 
    210                 215                 220                 


Asp Glu Val Cys Ala Leu Glu Glu Lys Glu Pro Gln Lys Asn Glu Ser 
225                 230                 235                 240 


Ser Asn Ala Ser Glu Glu Glu Ala Cys Glu Lys Lys Asp Pro Ala Thr 
                245                 250                 255     


Gln Gln Ala Phe Val Phe Gly Gln Asn Leu Arg Asp Arg Val Lys Leu 
            260                 265                 270         


Ile Asn Glu Ser Val Asp Glu Ala Asp Met Glu Asn Ala Gly His Pro 
        275                 280                 285             


Ser Ala Asp Thr Pro Thr Ala Thr Asn Tyr Phe Leu Gln Tyr Ile Ser 
    290                 295                 300                 


Ser Ser Leu Glu Asn Ser Thr Asn Ser Ala Asp Ala Ser Ser Asn Lys 
305                 310                 315                 320 


Phe Val Phe Gly Gln Asn Met Ser Glu Arg Val Leu Ser Pro Pro Lys 
                325                 330                 335     


Leu Asn Glu Val Ser Ser Asp Ala Asn Arg Glu Asn Ala Ala Ala Glu 
            340                 345                 350         


Ser Gly Ser Glu Ser Ser Ser Gln Glu Ala Thr Pro Glu Lys Glu Ser 
        355                 360                 365             


Leu Ala Glu Ser Ala Ala Ala Tyr Thr Lys Ala Thr Ala Arg Lys Cys 
    370                 375                 380                 


Leu Leu Glu Lys Val Glu Val Ile Thr Gly Glu Glu Ala Glu Ser Asn 
385                 390                 395                 400 


Val Leu Gln Met Gln Cys Lys Leu Phe Val Phe Asp Lys Thr Ser Gln 
                405                 410                 415     


Ser Trp Val Glu Arg Gly Arg Gly Leu Leu Arg Leu Asn Asp Met Ala 
            420                 425                 430         


Ser Thr Asp Asp Gly Thr Leu Gln Ser Arg Leu Val Met Arg Thr Gln 
        435                 440                 445             


Gly Ser Leu Arg Leu Ile Leu Asn Thr Lys Leu Trp Ala Gln Met Gln 
    450                 455                 460                 


Ile Asp Lys Ala Ser Glu Lys Ser Ile Arg Ile Thr Ala Met Asp Thr 
465                 470                 475                 480 


Glu Asp Gln Gly Val Lys Val Phe Leu Ile Ser Ala Ser Ser Lys Asp 
                485                 490                 495     


Thr Gly Gln Leu Tyr Ala Ala Leu His His Arg Ile Leu Ala Leu Arg 
            500                 505                 510         


Ser Arg Val Glu Gln Glu Gln Glu Ala Lys Met Pro Ala Pro Glu Pro 
        515                 520                 525             


Gly Ala Ala Pro Ser Asn Glu Glu Asp Asp Ser Asp Asp Asp Asp Val 
    530                 535                 540                 


Leu Ala Pro Ser Gly Ala Thr Ala Ala Gly Ala Gly Asp Glu Gly Asp 
545                 550                 555                 560 


Gly Gln Thr Thr Gly Ser Thr 
                565         

<210>  3449
<211>  2048
<212>  DNA
<213>  Homo sapiens

<400>  3449
gcagaaagca ggcgagcctg ggccggcgcg gggccttgtg ggagggctta aggaagtaaa     60

atggcggacc tggcgaacga agatgcagtg caagctgttt gtctttgaca agacctcaca    120

gtcctgggtg gagagaggcc gggggctgct cagactcaat gacatggcgt ccaccgatga    180

cggcacacta cagtcccgac tagtgatgcg gacccagggg agcctgcgac tgatcctcaa    240

caccaagctg tgggcccaga tgcagatcga caaggccagc gagaagagca ttcgcatcac    300

agccatggac accgaggacc agggcgtgaa ggtcttcctg atctcggcca gctccaagga    360

cacaggtcag ttgtatgcag ccctgcacca ccgcatcctg gccctgcgca gccgcgtgga    420

gcaggagcag gaggccaaga tgcccgcgcc tgagcctggg gcagccccat ccaacgagga    480

ggacgacagc gacgatgacg atgtcctggc tccttcaggg gccaccgcag ctggtgctgg    540

tgacgaaggg gacgggcaga cgaccgggag cacatagcgg ccgggagccc ggctgcacac    600

caggctgctg ctttgtccgt ctatccaccc gcccacccgc ccccacccca ccggcagcgt    660

ccaggtgcgg ggccgggaac cacacacccc actgggccgg ccacagtctg gacccgcacg    720

tcctgttcaa aagcagactc gggaactgcc tgaatgtggt ttgggacacg agacctcatc    780

atattgatga gcgaacaaac aagaacattt cctccctccc ctcctttgaa ttgaaatggc    840

acattaagac ttgtcacggc ttctcactgg gactggagac ctcgttcctt caccccgcgt    900

gtcgccagcc tctgggtcca gccagagccc ctggcttctc cgccacccac acccttccca    960

ccctgctgtg gggccctgcc tttgtgggga gcagccagcc ctctgcccct gcccagggct   1020

ccccaactat aggcctggga cccccgccca gcttgggggg ctgctcgtac gagtgtagac   1080

actgggccca ttggacgtgc tgttaactac tatcttcatt tcccacttcc cctctctgat   1140

tgggggtgta tattttacat ctttttttct ttttattttc gaaggctttg ttttggtttc   1200

ttaggttaag atgctctcga gcgttgagca ggcacagctc tgtcgaggtc cctgtccccc   1260

acctgtggtt ctggcctctg aggttggggg actacttgtt tcccacccca ggttcctcca   1320

ggccaagtca tggggtgatg aggagttggg gccctgtctg tcctaggcct ggagagtgcc   1380

tgtctgggaa aaggtcactg gacctggaag ggtccccagg gtcccctgac tcccgtctcc   1440

atctgtcacg tggttcacca tcatcaggca ccaggcgcaa actgcttccc gctgttggcc   1500

atcccttccc cagccacagg tgtccctgcc cccaggacag tccagggcca ggggcttctg   1560

tgagaggcag agggggaccc tcaccaaatc ttggtggaag agcccagggg ctggtcccag   1620

aacaggcagt ctcacaagca cgcagcacac tggagtggac gcctgtgccc acccgagcct   1680

ggagcatggc caagagccag cttgcaccac ccacctggga ggccgaggag gaggtcccct   1740

gggcacaggg cctctttggg acttcagagg aaatctccca gtcccactct cggagggtta   1800

agagaaggcc tcctgcagct gtgccgtcca cacctctagg tcgccagagc cctggccccc   1860

agcccccagc aagcctgagc ccgggaagaa ccagaggccc tcccgagaga cccagtcaca   1920

cgtctctgct ttaagcctta gccagctagt gacgagtaca acgagataac gcccatgtgt   1980

tttggaacat ttatgtaaga ttgtcatatg aaatgtattt gggaactaca ttaaactttt   2040

aactaaaa                                                            2048


<210>  3450
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  3450


Met Gln Pro Cys Thr Thr Ala Ser Trp Pro Cys Ala Ala Ala Trp Ser 
1               5                   10                  15      


Arg Ser Arg Arg Pro Arg Cys Pro Arg Leu Ser Leu Gly Gln Pro His 
            20                  25                  30          


Pro Thr Arg Arg Thr Thr Ala Thr Met Thr Met Ser Trp Leu Leu Gln 
        35                  40                  45              


Gly Pro Pro Gln Leu Val Leu Val Thr Lys Gly Thr Gly Arg Arg Pro 
    50                  55                  60                  


Gly Ala His Ser Gly Arg Glu Pro Gly Cys Thr Pro Gly Cys Cys Phe 
65                  70                  75                  80  


Val Arg Leu Ser Thr Arg Pro Pro Ala Pro Thr Pro Pro Ala Ala Ser 
                85                  90                  95      


Arg Cys Gly Ala Gly Asn His Thr Pro His Trp Ala Gly His Ser Leu 
            100                 105                 110         


Asp Pro His Val Leu Phe Lys Ser Arg Leu Gly Asn Cys Leu Asn Val 
        115                 120                 125             


Val Trp Asp Thr Arg Pro His His Ile Asp Glu Arg Thr Asn Lys Asn 
    130                 135                 140                 


Ile Ser Ser Leu Pro Ser Phe Glu Leu Lys Trp His Ile Lys Thr Cys 
145                 150                 155                 160 


His Gly Phe Ser Leu Gly Leu Glu Thr Ser Phe Leu His Pro Ala Cys 
                165                 170                 175     


Arg Gln Pro Leu Gly Pro Ala Arg Ala Pro Gly Phe Ser Ala Thr His 
            180                 185                 190         


Thr Leu Pro Thr Leu Leu Trp Gly Pro Ala Phe Val Gly Ser Ser Gln 
        195                 200                 205             


Pro Ser Ala Pro Ala Gln Gly Ser Pro Thr Ile Gly Leu Gly Pro Pro 
    210                 215                 220                 


Pro Ser Leu Gly Gly Cys Ser Tyr Glu Cys Arg His Trp Ala His Trp 
225                 230                 235                 240 


Thr Cys Cys 
            

<210>  3451
<211>  3198
<212>  DNA
<213>  Homo sapiens

<400>  3451
agatggctcg tgcgcaggtg cgtgctagga gcgcggctcg tcagggcagg ctgctctgca     60

gggcaggcga tccggggctc gcctccgcgc ggcattcagc gcgcaggcgc gagctggccg    120

cctcacacgg agtcggcttg ttaagtgcgc acgcgcggga gtttctggca gaaagcaggc    180

gagcctgggc cggcgcgggg ccttgtggga gggcttaagg aagtaaaatg gcggacctgg    240

cgaacgaaga aaagcctgcc attgctccgc ccgtctttgt gtttcagaag gataaaggac    300

aaaagaggtc agctggcggc tccagtcctg aaggcggaga agattctgac agagaagatg    360

gaaattactg ccctcctgtc aagcgagaaa gaacatcctc tttaacccag ttcccaccct    420

cacagtcaga ggaaaggagc agtggcttcc ggttgaagcc accaacgctg atccacggcc    480

aagcccccag cgcaggtctg ccaagccaga agcccaagga gcagcagcgg agcgtgcttc    540

gcccggcagt gttacaagct ccgcagccaa aggcgctgtc ccagactgtc cccagcagtg    600

gcaccaacgg ggtcagcctc ccagcagact gcacgggggc agtgcccgca gcatcccctg    660

acactgctgc atggagaagt ccttccgaag ctgccgatga ggtgtgtgca cttgaggaga    720

aagagcccca gaaaaatgag tccagcaatg cctctgaaga ggaagcctgt gagaaaaaag    780

accccgccac acagcaagcc tttgtatttg ggcagaactt gagggacaga gttaagctga    840

taaatgagag cgtggacgaa gccgacatgg agaatgctgg acaccccagc gcagacacgc    900

caaccgcaac gaactatttc ctccagtata tcagttccag tttagagaac tcaaccaata    960

gtgccgacgc ctccagcaac aaatttgtat ttggccagaa catgagcgag cgagttttga   1020

gccccccaaa attaaacgag gtcagttcag atgccaacag ggaaaatgca gctgccgagt   1080

cagggtctga gtcctcgtcc caggaggcca cccctgagaa agagtccctg gctgagtcgg   1140

cagccgccta caccaaggca acagcgcgga agtgtttgtt ggaaaaagtg gaagtcatca   1200

ccggggagga ggcggagagc aatgtgttac agatgcagtg caagctgttt gtctttgaca   1260

agacctcaca gtcctgggtg gagagaggcc gggggctgct cagactcaat gacatggcgt   1320

ccaccgatga cggcacacta cagtcccgac tagtgatgcg gacccagggg agcctgcgac   1380

tgatcctcaa caccaagctg tgggcccaga tgcagatcga caaggccagc gagaagagca   1440

ttcgcatcac agccatggac accgaggacc agggcgtgaa ggtcttcctg atctcggcca   1500

gctccaagga cacaggtcag ttgtatgcag ccctgcacca ccgcatcctg gccctgcgca   1560

gccgcgtgga gcaggagcag gaggccaaga tgcccgcgcc tgagcctggg gcagccccat   1620

ccaacgagga ggacgacagc gacgatgacg atgtcctggc tccttcaggg gccaccgcag   1680

ctggtgctgg tgacgaaggg gacgggcaga cgaccgggag cacatagcgg ccgggagccc   1740

ggctgcacac caggctgctg ctttgtccgt ctatccaccc gcccacccgc ccccacccca   1800

ccggcagcgt ccaggtgcgg ggccgggaac cacacacccc actgggccgg ccacagtctg   1860

gacccgcacg tcctgttcaa aagcagactc gggaactgcc tgaatgtggt ttgggacacg   1920

agacctcatc atattgatga gcgaacaaac aagaacattt cctccctccc ctcctttgaa   1980

ttgaaatggc acattaagac ttgtcacggc ttctcactgg gactggagac ctcgttcctt   2040

caccccgcgt gtcgccagcc tctgggtcca gccagagccc ctggcttctc cgccacccac   2100

acccttccca ccctgctgtg gggccctgcc tttgtgggga gcagccagcc ctctgcccct   2160

gcccagggct ccccaactat aggcctggga cccccgccca gcttgggggg ctgctcgtac   2220

gagtgtagac actgggccca ttggacgtgc tgttaactac tatcttcatt tcccacttcc   2280

cctctctgat tgggggtgta tattttacat ctttttttct ttttattttc gaaggctttg   2340

ttttggtttc ttaggttaag atgctctcga gcgttgagca ggcacagctc tgtcgaggtc   2400

cctgtccccc acctgtggtt ctggcctctg aggttggggg actacttgtt tcccacccca   2460

ggttcctcca ggccaagtca tggggtgatg aggagttggg gccctgtctg tcctaggcct   2520

ggagagtgcc tgtctgggaa aaggtcactg gacctggaag ggtccccagg gtcccctgac   2580

tcccgtctcc atctgtcacg tggttcacca tcatcaggca ccaggcgcaa actgcttccc   2640

gctgttggcc atcccttccc cagccacagg tgtccctgcc cccaggacag tccagggcca   2700

ggggcttctg tgagaggcag agggggaccc tcaccaaatc ttggtggaag agcccagggg   2760

ctggtcccag aacaggcagt ctcacaagca cgcagcacac tggagtggac gcctgtgccc   2820

acccgagcct ggagcatggc caagagccag cttgcaccac ccacctggga ggccgaggag   2880

gaggtcccct gggcacaggg cctctttggg acttcagagg aaatctccca gtcccactct   2940

cggagggtta agagaaggcc tcctgcagct gtgccgtcca cacctctagg tcgccagagc   3000

cctggccccc agcccccagc aagcctgagc ccgggaagaa ccagaggccc tcccgagaga   3060

cccagtcaca cgtctctgct ttaagcctta gccagctagt gacgagtaca acgagataac   3120

gcccatgtgt tttggaacat ttatgtaaga ttgtcatatg aaatgtattt gggaactaca   3180

ttaaactttt aactaaaa                                                 3198


<210>  3452
<211>  499
<212>  PRT
<213>  Homo sapiens

<400>  3452


Met Ala Asp Leu Ala Asn Glu Glu Lys Pro Ala Ile Ala Pro Pro Val 
1               5                   10                  15      


Phe Val Phe Gln Lys Asp Lys Gly Gln Lys Arg Ser Ala Gly Gly Ser 
            20                  25                  30          


Ser Pro Glu Gly Gly Glu Asp Ser Asp Arg Glu Asp Gly Asn Tyr Cys 
        35                  40                  45              


Pro Pro Val Lys Arg Glu Arg Thr Ser Ser Leu Thr Gln Phe Pro Pro 
    50                  55                  60                  


Ser Gln Ser Glu Glu Arg Ser Ser Gly Phe Arg Leu Lys Pro Pro Thr 
65                  70                  75                  80  


Leu Ile His Gly Gln Ala Pro Ser Ala Gly Leu Pro Ser Gln Lys Pro 
                85                  90                  95      


Lys Glu Gln Gln Arg Ser Val Leu Arg Pro Ala Val Leu Gln Ala Pro 
            100                 105                 110         


Gln Pro Lys Ala Leu Ser Gln Thr Val Pro Ser Ser Gly Thr Asn Gly 
        115                 120                 125             


Val Ser Leu Pro Ala Asp Cys Thr Gly Ala Val Pro Ala Ala Ser Pro 
    130                 135                 140                 


Asp Thr Ala Ala Trp Arg Ser Pro Ser Glu Ala Ala Asp Glu Val Cys 
145                 150                 155                 160 


Ala Leu Glu Glu Lys Glu Pro Gln Lys Asn Glu Ser Ser Asn Ala Ser 
                165                 170                 175     


Glu Glu Glu Ala Cys Glu Lys Lys Asp Pro Ala Thr Gln Gln Ala Phe 
            180                 185                 190         


Val Phe Gly Gln Asn Leu Arg Asp Arg Val Lys Leu Ile Asn Glu Ser 
        195                 200                 205             


Val Asp Glu Ala Asp Met Glu Asn Ala Gly His Pro Ser Ala Asp Thr 
    210                 215                 220                 


Pro Thr Ala Thr Asn Tyr Phe Leu Gln Tyr Ile Ser Ser Ser Leu Glu 
225                 230                 235                 240 


Asn Ser Thr Asn Ser Ala Asp Ala Ser Ser Asn Lys Phe Val Phe Gly 
                245                 250                 255     


Gln Asn Met Ser Glu Arg Val Leu Ser Pro Pro Lys Leu Asn Glu Val 
            260                 265                 270         


Ser Ser Asp Ala Asn Arg Glu Asn Ala Ala Ala Glu Ser Gly Ser Glu 
        275                 280                 285             


Ser Ser Ser Gln Glu Ala Thr Pro Glu Lys Glu Ser Leu Ala Glu Ser 
    290                 295                 300                 


Ala Ala Ala Tyr Thr Lys Ala Thr Ala Arg Lys Cys Leu Leu Glu Lys 
305                 310                 315                 320 


Val Glu Val Ile Thr Gly Glu Glu Ala Glu Ser Asn Val Leu Gln Met 
                325                 330                 335     


Gln Cys Lys Leu Phe Val Phe Asp Lys Thr Ser Gln Ser Trp Val Glu 
            340                 345                 350         


Arg Gly Arg Gly Leu Leu Arg Leu Asn Asp Met Ala Ser Thr Asp Asp 
        355                 360                 365             


Gly Thr Leu Gln Ser Arg Leu Val Met Arg Thr Gln Gly Ser Leu Arg 
    370                 375                 380                 


Leu Ile Leu Asn Thr Lys Leu Trp Ala Gln Met Gln Ile Asp Lys Ala 
385                 390                 395                 400 


Ser Glu Lys Ser Ile Arg Ile Thr Ala Met Asp Thr Glu Asp Gln Gly 
                405                 410                 415     


Val Lys Val Phe Leu Ile Ser Ala Ser Ser Lys Asp Thr Gly Gln Leu 
            420                 425                 430         


Tyr Ala Ala Leu His His Arg Ile Leu Ala Leu Arg Ser Arg Val Glu 
        435                 440                 445             


Gln Glu Gln Glu Ala Lys Met Pro Ala Pro Glu Pro Gly Ala Ala Pro 
    450                 455                 460                 


Ser Asn Glu Glu Asp Asp Ser Asp Asp Asp Asp Val Leu Ala Pro Ser 
465                 470                 475                 480 


Gly Ala Thr Ala Ala Gly Ala Gly Asp Glu Gly Asp Gly Gln Thr Thr 
                485                 490                 495     


Gly Ser Thr 
            

<210>  3453
<211>  2366
<212>  DNA
<213>  Homo sapiens

<400>  3453
agaaagcagg cgagcctggg ccggcgcggg gccttgtggg agggcttaag gaagtaaaat     60

ggcggacctg gcgaacgaag aaaagcctgc cattgctccg cccgtctttg tgtttcagaa    120

ggataaagga caaaagtccc ctgcagagca aaaaaacttg tcggattcgg gagaggagcc    180

tcggggggag gctgaggccc cccaccatgg cacgggtcac cccgagtcag ctggcgagca    240

tgccctagaa cctcctgccc ctgctggcgc ctcagccagc actcctccgc ctcccgctcc    300

tgaagcccag cttcctcctt ttccgcgaga actggcaggg aggtcagctg gcggctccag    360

tcctgaaggc ggagaagatt ctgacagaga agatggaaat tactgccctc ctgtcaagcg    420

agaaagaaca tcctctttaa cccagttccc accctcacag tcagaggaaa ggagcagtgg    480

cttccggttg aagccaccaa cgctgatcca cggccaagcc cccagcgcag gtctgccaag    540

ccagaagccc aaggagcagc agcggagcgt gcttcgcccg gcagtgttac aagctccgca    600

gccaaaggcg ctgtcccaga ctgtccccag cagtggcacc aacggggtca gcctcccagc    660

agactgcacg ggggcagtgc ccgcagcatc ccctgacact gctgcatgga gaagtccttc    720

cgaagctgcc gatgaggtgt gtgcacttga ggagaaagag ccccagaaaa atgagtccag    780

caatgcctct gaagaggaag cctgtgagaa aaaagacccc gccacacagc aagcctttgt    840

atttgggcag aacttgaggg acagagttaa gctgataaat gagagcgtgg acgaagccga    900

catggagaat gctggacacc ccagcgcaga cacgccaacc gcaacgaact atttcctcca    960

gtatatcagt tccagtttag agaactcaac caatagtgcc gacgcctcca gcaacaaatt   1020

tgtatttggc cagaacatga gcgagcgagt tttgagcccc ccaaaattaa acgaggtcag   1080

ttcagatgcc aacagggaaa atgcagctgc cgagtcaggg tctgagtcct cgtcccagga   1140

ggccacccct gagaaagagt ccctggctga gtcggcagcc gcctacacca aggcaacagc   1200

gcggaagtgt ttgttggaaa aagtggaagt catcaccggg gaggaggcgg agagcaatgt   1260

gttacagatg cagtgcaagc tgtttgtctt tgacaagacc tcacagtcct gggtggagag   1320

aggccggggg ctgctcagac tcaatgacat ggcgtccacc gatgacggca cactacagtc   1380

ccgactagtg atgcggaccc aggggagcct gcgactgatc ctcaacacca agctgtgggc   1440

ccagatgcag atcgacaagg ccagcgagaa gagcattcgc atcacagcca tggacaccga   1500

ggaccagggc gtgaaggtct tcctgatctc ggccagctcc aaggacacag gtcagttgta   1560

tgcagccctg caccaccgca tcctggccct gcgcagccgc gtggagcagg agcaggaggc   1620

caagatgccc gcgcctgagc ctggggcagc cccatccaac gaggaggacg acagcgacga   1680

tgacgatgtc ctggctcctt caggggccac cgcagctggt gctggtgacg aaggggacgg   1740

gcagacgacc gggagcacat agcggccggg agcccggctg cacaccaggc tgctgctttg   1800

tccgtctatc cacccgccca cccgccccca ccccaccggc agcgtccagg tgcggggccg   1860

ggaaccacac accccactgg gccggccaca gtctggaccc gcacgtcctg ttcaaaagca   1920

gactcgggaa ctgcctgaat gtggtttggg acacgagacc tcatcatatt gatgagcgaa   1980

caaacaagaa catttcctcc ctcccctcct ttgaattgaa atggcacatt aagacttgtc   2040

acggcttctc actgggactg gagacctcgt tccttcaccc cgcgtgtcgc cagcctctgg   2100

gtccagccag agcccctggc ttctccgcca cccacaccct tcccaccctg ctgtggggcc   2160

ctgcctttgt ggggagcagc cagccctctg cccctgccca gggctcccca actataggcc   2220

tgggaccccc gcccagcttg gggggctgct cgtacgagtg tagacactgg gcccattgga   2280

cgtgctgtta actactatct tcatttccca cttcccctct ctgattgggg gtgtatattt   2340

tacatctttt tttcttttta ttttcg                                        2366


<210>  3454
<211>  567
<212>  PRT
<213>  Homo sapiens

<400>  3454


Met Ala Asp Leu Ala Asn Glu Glu Lys Pro Ala Ile Ala Pro Pro Val 
1               5                   10                  15      


Phe Val Phe Gln Lys Asp Lys Gly Gln Lys Ser Pro Ala Glu Gln Lys 
            20                  25                  30          


Asn Leu Ser Asp Ser Gly Glu Glu Pro Arg Gly Glu Ala Glu Ala Pro 
        35                  40                  45              


His His Gly Thr Gly His Pro Glu Ser Ala Gly Glu His Ala Leu Glu 
    50                  55                  60                  


Pro Pro Ala Pro Ala Gly Ala Ser Ala Ser Thr Pro Pro Pro Pro Ala 
65                  70                  75                  80  


Pro Glu Ala Gln Leu Pro Pro Phe Pro Arg Glu Leu Ala Gly Arg Ser 
                85                  90                  95      


Ala Gly Gly Ser Ser Pro Glu Gly Gly Glu Asp Ser Asp Arg Glu Asp 
            100                 105                 110         


Gly Asn Tyr Cys Pro Pro Val Lys Arg Glu Arg Thr Ser Ser Leu Thr 
        115                 120                 125             


Gln Phe Pro Pro Ser Gln Ser Glu Glu Arg Ser Ser Gly Phe Arg Leu 
    130                 135                 140                 


Lys Pro Pro Thr Leu Ile His Gly Gln Ala Pro Ser Ala Gly Leu Pro 
145                 150                 155                 160 


Ser Gln Lys Pro Lys Glu Gln Gln Arg Ser Val Leu Arg Pro Ala Val 
                165                 170                 175     


Leu Gln Ala Pro Gln Pro Lys Ala Leu Ser Gln Thr Val Pro Ser Ser 
            180                 185                 190         


Gly Thr Asn Gly Val Ser Leu Pro Ala Asp Cys Thr Gly Ala Val Pro 
        195                 200                 205             


Ala Ala Ser Pro Asp Thr Ala Ala Trp Arg Ser Pro Ser Glu Ala Ala 
    210                 215                 220                 


Asp Glu Val Cys Ala Leu Glu Glu Lys Glu Pro Gln Lys Asn Glu Ser 
225                 230                 235                 240 


Ser Asn Ala Ser Glu Glu Glu Ala Cys Glu Lys Lys Asp Pro Ala Thr 
                245                 250                 255     


Gln Gln Ala Phe Val Phe Gly Gln Asn Leu Arg Asp Arg Val Lys Leu 
            260                 265                 270         


Ile Asn Glu Ser Val Asp Glu Ala Asp Met Glu Asn Ala Gly His Pro 
        275                 280                 285             


Ser Ala Asp Thr Pro Thr Ala Thr Asn Tyr Phe Leu Gln Tyr Ile Ser 
    290                 295                 300                 


Ser Ser Leu Glu Asn Ser Thr Asn Ser Ala Asp Ala Ser Ser Asn Lys 
305                 310                 315                 320 


Phe Val Phe Gly Gln Asn Met Ser Glu Arg Val Leu Ser Pro Pro Lys 
                325                 330                 335     


Leu Asn Glu Val Ser Ser Asp Ala Asn Arg Glu Asn Ala Ala Ala Glu 
            340                 345                 350         


Ser Gly Ser Glu Ser Ser Ser Gln Glu Ala Thr Pro Glu Lys Glu Ser 
        355                 360                 365             


Leu Ala Glu Ser Ala Ala Ala Tyr Thr Lys Ala Thr Ala Arg Lys Cys 
    370                 375                 380                 


Leu Leu Glu Lys Val Glu Val Ile Thr Gly Glu Glu Ala Glu Ser Asn 
385                 390                 395                 400 


Val Leu Gln Met Gln Cys Lys Leu Phe Val Phe Asp Lys Thr Ser Gln 
                405                 410                 415     


Ser Trp Val Glu Arg Gly Arg Gly Leu Leu Arg Leu Asn Asp Met Ala 
            420                 425                 430         


Ser Thr Asp Asp Gly Thr Leu Gln Ser Arg Leu Val Met Arg Thr Gln 
        435                 440                 445             


Gly Ser Leu Arg Leu Ile Leu Asn Thr Lys Leu Trp Ala Gln Met Gln 
    450                 455                 460                 


Ile Asp Lys Ala Ser Glu Lys Ser Ile Arg Ile Thr Ala Met Asp Thr 
465                 470                 475                 480 


Glu Asp Gln Gly Val Lys Val Phe Leu Ile Ser Ala Ser Ser Lys Asp 
                485                 490                 495     


Thr Gly Gln Leu Tyr Ala Ala Leu His His Arg Ile Leu Ala Leu Arg 
            500                 505                 510         


Ser Arg Val Glu Gln Glu Gln Glu Ala Lys Met Pro Ala Pro Glu Pro 
        515                 520                 525             


Gly Ala Ala Pro Ser Asn Glu Glu Asp Asp Ser Asp Asp Asp Asp Val 
    530                 535                 540                 


Leu Ala Pro Ser Gly Ala Thr Ala Ala Gly Ala Gly Asp Glu Gly Asp 
545                 550                 555                 560 


Gly Gln Thr Thr Gly Ser Thr 
                565         

<210>  3455
<211>  693
<212>  DNA
<213>  Homo sapiens

<400>  3455
gacgacagcg acgatgacga tgtcctggct ccttcagggg ccaccgcagc tggtgctggt     60

gacgaagggg acgggcagac gaccgggagc acatagcggc cgggagcccg gctgcacacc    120

aggctgctgc tttgtccgtc tatccacccg cccacccgcc cccaccccac cggcagcgtc    180

caggtgcggg gccgggaacc acacacccca ctgggccggc cacagtctgg acccgcacgt    240

cctgttcaaa agcagactcg ggaactgcct gaatgtggtt tgggacacga gacctcatca    300

tattgatgag cgaacaaaca agaacatttc ctccctcccc tcctttgaat tgaaatggca    360

cattaagact tgtcacggct tctcactggg actggagacc tcgttccttc accccgcgtg    420

tcgccagcct ctgggtccag ccagagcccc tggcttctcc gccacccaca cccttcccac    480

cctgctgtgg ggccctgcct ttgtggggag cagccagccc tctgcccctg cccagggctc    540

cccaactata ggcctgggac ccccgcccag cttggggggc tgctcgtacg agtgtagaca    600

ctgggcccat tggacgtgct gttaactact atcttcattt cccacttccc ctctctgatt    660

gggggtgtat attttacatc tttttttctt ttt                                 693


<210>  3456
<211>  203
<212>  PRT
<213>  Homo sapiens

<400>  3456


Met Thr Met Ser Trp Leu Leu Gln Gly Pro Pro Gln Leu Val Leu Val 
1               5                   10                  15      


Thr Lys Gly Thr Gly Arg Arg Pro Gly Ala His Ser Gly Arg Glu Pro 
            20                  25                  30          


Gly Cys Thr Pro Gly Cys Cys Phe Val Arg Leu Ser Thr Arg Pro Pro 
        35                  40                  45              


Ala Pro Thr Pro Pro Ala Ala Ser Arg Cys Gly Ala Gly Asn His Thr 
    50                  55                  60                  


Pro His Trp Ala Gly His Ser Leu Asp Pro His Val Leu Phe Lys Ser 
65                  70                  75                  80  


Arg Leu Gly Asn Cys Leu Asn Val Val Trp Asp Thr Arg Pro His His 
                85                  90                  95      


Ile Asp Glu Arg Thr Asn Lys Asn Ile Ser Ser Leu Pro Ser Phe Glu 
            100                 105                 110         


Leu Lys Trp His Ile Lys Thr Cys His Gly Phe Ser Leu Gly Leu Glu 
        115                 120                 125             


Thr Ser Phe Leu His Pro Ala Cys Arg Gln Pro Leu Gly Pro Ala Arg 
    130                 135                 140                 


Ala Pro Gly Phe Ser Ala Thr His Thr Leu Pro Thr Leu Leu Trp Gly 
145                 150                 155                 160 


Pro Ala Phe Val Gly Ser Ser Gln Pro Ser Ala Pro Ala Gln Gly Ser 
                165                 170                 175     


Pro Thr Ile Gly Leu Gly Pro Pro Pro Ser Leu Gly Gly Cys Ser Tyr 
            180                 185                 190         


Glu Cys Arg His Trp Ala His Trp Thr Cys Cys 
        195                 200             

<210>  3457
<211>  3232
<212>  DNA
<213>  Homo sapiens

<400>  3457
gtcgcccagg ctggagtgca gtggtacagt cgtaactcaa ctgtaacctc aagctcccag     60

gctcaagtga tcttcccacc tctgcctcct gagtagctgg gactacaggc atgtaccacc    120

atgcctggct aagtttttaa ttttttgtag agttagggtc ttgcagtgtt gcccaggctg    180

atctcaaact cttgggctca tgcagtcctc ctgcctcagc ctcccaaagc actgggatta    240

caggcatgag ccactgcacc cggccctaac attgttttat agttttatct tgtgaaatgt    300

attcccaagt attttattcc ttttggtgtt attgtaaatg gaattatttt cttaattttg    360

cttttgggtc attcactgct agtgttagaa acacaatcga tttttgtata ttgatcttgt    420

gtcctgtagc ttgacaaggg ggtgaagctt agcacaaacg cagggctacc tccaggagcc    480

ataatgccac agtctctgtg ccttgcccag gaacaggctt gcctgcctga gtcacaggcc    540

ttttatgaca atccttcctg ttgtggatca gattagacca ccatccccac tccctgtatg    600

ggcacagttg ccaagacaca cagatgaagg ggtccatgtg gacaggtggc tgggcgaggc    660

tgggctctcg agccatccca ggagctcgtg ggcattcacc tttccctcta gttttgtgaa    720

tttgtcagcc cggactctgg cccaggggga gctggcctcc tccacggtgg ccaggagtgc    780

cccctcactg agacgggaag ctccgcaggc acatctggaa aggggaggca ggctcactgt    840

gtgccacctt tgaccttttc atcacaaaaa cctgtctcac ttcccagaca tctgtagtgg    900

tgccaaggtt cttcctggcc acagccgcat cctctgacag acaagccttc taggaaaggg    960

aagtggggcc tgagcgcctg tgttccgtgg ctccctgaca ttctccagag ccaggtacag   1020

ggccgctgag cagctcggct cctgagcctg cagcaggtca tagacagctg ggagggcggc   1080

tgacgcccca cctgccccca tggtcagcag ctggcccaag agccatcgtt cctcctgccc   1140

ttgtctctcc cctcctccag gcgccttcca ggcctgctga tcggacgaga cttctgttgt   1200

aatttggaaa tgttctccct ggttctccag gcccgaagtc actgaggcca agaccatagt   1260

cctctcctgc ccttgccccc caggcccagc cccagcccag gcaggcctgc tgttgatatt   1320

ttgtcttgtg cttttagagg aaaggagcag tggcttccgg ttgaagccac caacgctgat   1380

ccacggccaa gcccccagcg caggtctgcc aagccagaag cccaaggagc agcagcggag   1440

cgtgcttcgc ccggcagtgt tacaagctcc gcagccaaag gcgctgtccc agactgtccc   1500

cagcagtggc accaacgggg tcagcctccc agcagactgc acgggggcag tgcccgcagc   1560

atcccctgac actgctgcat ggagaagtcc ttccgaagct gccgatgagg tgtgtgcact   1620

tgaggagaaa gagccccaga aaaatgagtc cagcaatgcc tctgaagagg aagcctgtga   1680

gaaaaaagac cccgccacac agcaagcctt tgtatttggg cagaacttga gggacagagt   1740

taagctgata aatgagagcg tggacgaagc cgacatggag aatgctggac accccagcgc   1800

agacacgcca accgcaacga actatttcct ccagtatatc agttccagtt tagagaactc   1860

aaccaatagt gccgacgcct ccagcaacaa atttgtattt ggccagaaca tgagcgagcg   1920

agttttgagc cccccaaaat taaacgaggt cagttcagat gccaacaggg aaaatgcagc   1980

tgccgagtca gggtctgagt cctcgtccca ggaggccacc cctgagaaag agtccctggc   2040

tgagtcggca gccgcctaca ccaaggcaac agcgcggaag tgtttgttgg aaaaagtgga   2100

agtcatcacc ggggaggagg cggagagcaa tgtgttacag atgcagtgca agctgtttgt   2160

ctttgacaag acctcacagt cctgggtgga gagaggccgg gggctgctca gactcaatga   2220

catggcgtcc accgatgacg gcacactaca gtcccgacta gtgatgcgga cccaggggag   2280

cctgcgactg atcctcaaca ccaagctgtg ggcccagatg cagatcgaca aggccagcga   2340

gaagagcatt cgcatcacag ccatggacac cgaggaccag ggcgtgaagg tcttcctgat   2400

ctcggccagc tccaaggaca caggtcagtt gtatgcagcc ctgcaccacc gcatcctggc   2460

cctgcgcagc cgcgtggagc aggagcagga ggccaagatg cccgcgcctg agcctggggc   2520

agccccatcc aacgaggagg acgacagcga cgatgacgat gtcctggctc cttcaggggc   2580

caccgcagct ggtgctggtg acgaagggga cgggcagacg accgggagca catagcggcc   2640

gggagcccgg ctgcacacca ggctgctgct ttgtccgtct atccacccgc ccacccgccc   2700

ccaccccacc ggcagcgtcc aggtgcgggg ccgggaacca cacaccccac tgggccggcc   2760

acagtctgga cccgcacgtc ctgttcaaaa gcagactcgg gaactgcctg aatgtggttt   2820

gggacacgag acctcatcat attgatgagc gaacaaacaa gaacatttcc tccctcccct   2880

cctttgaatt gaaatggcac attaagactt gtcacggctt ctcactggga ctggagacct   2940

cgttccttca ccccgcgtgt cgccagcctc tgggtccagc cagagcccct ggcttctccg   3000

ccacccacac ccttcccacc ctgctgtggg gccctgcctt tgtggggagc agccagccct   3060

ctgcccctgc ccagggctcc ccaactatag gcctgggacc cccgcccagc ttggggggct   3120

gctcgtacga gtgtagacac tgggcccatt ggacgtgctg ttaactacta tcttcatttc   3180

ccacttcccc tctctgattg ggggtgtata ttttacatct ttttttcttt tt           3232


<210>  3458
<211>  286
<212>  PRT
<213>  Homo sapiens

<400>  3458


Met Glu Asn Ala Gly His Pro Ser Ala Asp Thr Pro Thr Ala Thr Asn 
1               5                   10                  15      


Tyr Phe Leu Gln Tyr Ile Ser Ser Ser Leu Glu Asn Ser Thr Asn Ser 
            20                  25                  30          


Ala Asp Ala Ser Ser Asn Lys Phe Val Phe Gly Gln Asn Met Ser Glu 
        35                  40                  45              


Arg Val Leu Ser Pro Pro Lys Leu Asn Glu Val Ser Ser Asp Ala Asn 
    50                  55                  60                  


Arg Glu Asn Ala Ala Ala Glu Ser Gly Ser Glu Ser Ser Ser Gln Glu 
65                  70                  75                  80  


Ala Thr Pro Glu Lys Glu Ser Leu Ala Glu Ser Ala Ala Ala Tyr Thr 
                85                  90                  95      


Lys Ala Thr Ala Arg Lys Cys Leu Leu Glu Lys Val Glu Val Ile Thr 
            100                 105                 110         


Gly Glu Glu Ala Glu Ser Asn Val Leu Gln Met Gln Cys Lys Leu Phe 
        115                 120                 125             


Val Phe Asp Lys Thr Ser Gln Ser Trp Val Glu Arg Gly Arg Gly Leu 
    130                 135                 140                 


Leu Arg Leu Asn Asp Met Ala Ser Thr Asp Asp Gly Thr Leu Gln Ser 
145                 150                 155                 160 


Arg Leu Val Met Arg Thr Gln Gly Ser Leu Arg Leu Ile Leu Asn Thr 
                165                 170                 175     


Lys Leu Trp Ala Gln Met Gln Ile Asp Lys Ala Ser Glu Lys Ser Ile 
            180                 185                 190         


Arg Ile Thr Ala Met Asp Thr Glu Asp Gln Gly Val Lys Val Phe Leu 
        195                 200                 205             


Ile Ser Ala Ser Ser Lys Asp Thr Gly Gln Leu Tyr Ala Ala Leu His 
    210                 215                 220                 


His Arg Ile Leu Ala Leu Arg Ser Arg Val Glu Gln Glu Gln Glu Ala 
225                 230                 235                 240 


Lys Met Pro Ala Pro Glu Pro Gly Ala Ala Pro Ser Asn Glu Glu Asp 
                245                 250                 255     


Asp Ser Asp Asp Asp Asp Val Leu Ala Pro Ser Gly Ala Thr Ala Ala 
            260                 265                 270         


Gly Ala Gly Asp Glu Gly Asp Gly Gln Thr Thr Gly Ser Thr 
        275                 280                 285     

<210>  3459
<211>  1962
<212>  DNA
<213>  Homo sapiens

<400>  3459
gcctgggccg gcgcggggcc ttgtgggagg gcttaaggaa gtaaaatggc ggacctggcg     60

aacgaagagg aaaggagcag tggcttccgg ttgaagccac caacgctgat ccacggccaa    120

gcccccagcg caggtctgcc aagccagaag cccaaggagc agcagcggag cgtgcttcgc    180

ccggcagtgt tacaagctcc gcagccaaag gcgctgtccc agactgtccc cagcagtggc    240

accaacgggg tcagcctccc agcagactgc acgggggcag tgcccgcagc atcccctgac    300

actgctgcat ggagaagtcc ttccgaagct gccgatgagg tgtgtgcact tgaggagaaa    360

gagccccaga aaaatgagtc cagcaatgcc tctgaagagg aagcctgtga gaaaaaagac    420

cccgccacac agcaagcctt tgtatttggg cagaacttga gggacagagt taagctgata    480

aatgagagcg tggacgaagc cgacatggag aatgctggac accccagcgc agacacgcca    540

accgcaacga actatttcct ccagtatatc agttccagtt tagagaactc aaccaatagt    600

gccgacgcct ccagcaacaa atttgtattt ggccagaaca tgagcgagcg agttttgagc    660

cccccaaaat taaacgaggt cagttcagat gccaacaggg aaaatgcagc tgccgagtca    720

gggtctgagt cctcgtccca ggaggccacc cctgagaaag agtccctggc tgagtcggca    780

gccgcctaca ccaaggcaac agcgcggaag tgtttgttgg aaaaagtgga agtcatcacc    840

ggggaggagg cggagagcaa tgtgttacag atgcagtgca agctgtttgt ctttgacaag    900

acctcacagt cctgggtgga gagaggccgg gggctgctca gactcaatga catggcgtcc    960

accgatgacg gcacactaca gtcccgacta gtgatgcgga cccaggggag cctgcgactg   1020

atcctcaaca ccaagctgtg ggcccagatg cagatcgaca aggccagcga gaagagcatt   1080

cgcatcacag ccatggacac cgaggaccag ggcgtgaagg tcttcctgat ctcggccagc   1140

tccaaggaca caggtcagtt gtatgcagcc ctgcaccacc gcatcctggc cctgcgcagc   1200

cgcgtggagc aggagcagga ggccaagatg cccgcgcctg agcctggggc agccccatcc   1260

aacgaggagg acgacagcga cgatgacgat gtcctggctc cttcaggggc caccgcagct   1320

ggtgctggtg acgaagggga cgggcagacg accgggagca catagcggcc gggagcccgg   1380

ctgcacacca ggctgctgct ttgtccgtct atccacccgc ccacccgccc ccaccccacc   1440

ggcagcgtcc aggtgcgggg ccgggaacca cacaccccac tgggccggcc acagtctgga   1500

cccgcacgtc ctgttcaaaa gcagactcgg gaactgcctg aatgtggttt gggacacgag   1560

acctcatcat attgatgagc gaacaaacaa gaacatttcc tccctcccct cctttgaatt   1620

gaaatggcac attaagactt gtcacggctt ctcactggga ctggagacct cgttccttca   1680

ccccgcgtgt cgccagcctc tgggtccagc cagagcccct ggcttctccg ccacccacac   1740

ccttcccacc ctgctgtggg gccctgcctt tgtggggagc agccagccct ctgcccctgc   1800

ccagggctcc ccaactatag gcctgggacc cccgcccagc ttggggggct gctcgtacga   1860

gtgtagacac tgggcccatt ggacgtgctg ttaactacta tcttcatttc ccacttcccc   1920

tctctgattg ggggtgtata ttttacatct ttttttcttt tt                      1962


<210>  3460
<211>  439
<212>  PRT
<213>  Homo sapiens

<400>  3460


Met Ala Asp Leu Ala Asn Glu Glu Glu Arg Ser Ser Gly Phe Arg Leu 
1               5                   10                  15      


Lys Pro Pro Thr Leu Ile His Gly Gln Ala Pro Ser Ala Gly Leu Pro 
            20                  25                  30          


Ser Gln Lys Pro Lys Glu Gln Gln Arg Ser Val Leu Arg Pro Ala Val 
        35                  40                  45              


Leu Gln Ala Pro Gln Pro Lys Ala Leu Ser Gln Thr Val Pro Ser Ser 
    50                  55                  60                  


Gly Thr Asn Gly Val Ser Leu Pro Ala Asp Cys Thr Gly Ala Val Pro 
65                  70                  75                  80  


Ala Ala Ser Pro Asp Thr Ala Ala Trp Arg Ser Pro Ser Glu Ala Ala 
                85                  90                  95      


Asp Glu Val Cys Ala Leu Glu Glu Lys Glu Pro Gln Lys Asn Glu Ser 
            100                 105                 110         


Ser Asn Ala Ser Glu Glu Glu Ala Cys Glu Lys Lys Asp Pro Ala Thr 
        115                 120                 125             


Gln Gln Ala Phe Val Phe Gly Gln Asn Leu Arg Asp Arg Val Lys Leu 
    130                 135                 140                 


Ile Asn Glu Ser Val Asp Glu Ala Asp Met Glu Asn Ala Gly His Pro 
145                 150                 155                 160 


Ser Ala Asp Thr Pro Thr Ala Thr Asn Tyr Phe Leu Gln Tyr Ile Ser 
                165                 170                 175     


Ser Ser Leu Glu Asn Ser Thr Asn Ser Ala Asp Ala Ser Ser Asn Lys 
            180                 185                 190         


Phe Val Phe Gly Gln Asn Met Ser Glu Arg Val Leu Ser Pro Pro Lys 
        195                 200                 205             


Leu Asn Glu Val Ser Ser Asp Ala Asn Arg Glu Asn Ala Ala Ala Glu 
    210                 215                 220                 


Ser Gly Ser Glu Ser Ser Ser Gln Glu Ala Thr Pro Glu Lys Glu Ser 
225                 230                 235                 240 


Leu Ala Glu Ser Ala Ala Ala Tyr Thr Lys Ala Thr Ala Arg Lys Cys 
                245                 250                 255     


Leu Leu Glu Lys Val Glu Val Ile Thr Gly Glu Glu Ala Glu Ser Asn 
            260                 265                 270         


Val Leu Gln Met Gln Cys Lys Leu Phe Val Phe Asp Lys Thr Ser Gln 
        275                 280                 285             


Ser Trp Val Glu Arg Gly Arg Gly Leu Leu Arg Leu Asn Asp Met Ala 
    290                 295                 300                 


Ser Thr Asp Asp Gly Thr Leu Gln Ser Arg Leu Val Met Arg Thr Gln 
305                 310                 315                 320 


Gly Ser Leu Arg Leu Ile Leu Asn Thr Lys Leu Trp Ala Gln Met Gln 
                325                 330                 335     


Ile Asp Lys Ala Ser Glu Lys Ser Ile Arg Ile Thr Ala Met Asp Thr 
            340                 345                 350         


Glu Asp Gln Gly Val Lys Val Phe Leu Ile Ser Ala Ser Ser Lys Asp 
        355                 360                 365             


Thr Gly Gln Leu Tyr Ala Ala Leu His His Arg Ile Leu Ala Leu Arg 
    370                 375                 380                 


Ser Arg Val Glu Gln Glu Gln Glu Ala Lys Met Pro Ala Pro Glu Pro 
385                 390                 395                 400 


Gly Ala Ala Pro Ser Asn Glu Glu Asp Asp Ser Asp Asp Asp Asp Val 
                405                 410                 415     


Leu Ala Pro Ser Gly Ala Thr Ala Ala Gly Ala Gly Asp Glu Gly Asp 
            420                 425                 430         


Gly Gln Thr Thr Gly Ser Thr 
        435                 

<210>  3461
<211>  1174
<212>  DNA
<213>  Homo sapiens

<400>  3461
gcagaaagca ggcgagcctg ggccggcgcg gggccttgtg ggagggctta aggaagtaaa     60

atggcggacc tggcgaacga agatgcagtg caagctgttt gtctttgaca agacctcaca    120

gtcctgggtg gagagaggcc gggggctgct cagactcaat gacatggcgt ccaccgatga    180

cggcacacta cagtcccgac tagtgatgcg gacccagggg agcctgcgac tgatcctcaa    240

caccaagctg tgggcccaga tgcagatcga caaggccagc gagaagagca ttcgcatcac    300

agccatggac accgaggacc agggcgtgaa ggtcttcctg atctcggcca gctccaagga    360

cacaggtcag ttgtatgcag ccctgcacca ccgcatcctg gccctgcgca gccgcgtgga    420

gcaggagcag gaggccaaga tgcccgcgcc tgagcctggg gcagccccat ccaacgagga    480

ggacgacagc gacgatgacg atgtcctggc tccttcaggg gccaccgcag ctggtgctgg    540

tgacgaaggg gacgggcaga cgaccgggag cacatagcgg ccgggagccc ggctgcacac    600

caggctgctg ctttgtccgt ctatccaccc gcccacccgc ccccacccca ccggcagcgt    660

ccaggtgcgg ggccgggaac cacacacccc actgggccgg ccacagtctg gacccgcacg    720

tcctgttcaa aagcagactc gggaactgcc tgaatgtggt ttgggacacg agacctcatc    780

atattgatga gcgaacaaac aagaacattt cctccctccc ctcctttgaa ttgaaatggc    840

acattaagac ttgtcacggc ttctcactgg gactggagac ctcgttcctt caccccgcgt    900

gtcgccagcc tctgggtcca gccagagccc ctggcttctc cgccacccac acccttccca    960

ccctgctgtg gggccctgcc tttgtgggga gcagccagcc ctctgcccct gcccagggct   1020

ccccaactat aggcctggga cccccgccca gcttgggggg ctgctcgtac gagtgtagac   1080

actgggccca ttggacgtgc tgttaactac tatcttcatt tcccacttcc cctctctgat   1140

tgggggtgta tattttacat ctttttttct tttt                               1174


<210>  3462
<211>  243
<212>  PRT
<213>  Homo sapiens

<400>  3462


Met Gln Pro Cys Thr Thr Ala Ser Trp Pro Cys Ala Ala Ala Trp Ser 
1               5                   10                  15      


Arg Ser Arg Arg Pro Arg Cys Pro Arg Leu Ser Leu Gly Gln Pro His 
            20                  25                  30          


Pro Thr Arg Arg Thr Thr Ala Thr Met Thr Met Ser Trp Leu Leu Gln 
        35                  40                  45              


Gly Pro Pro Gln Leu Val Leu Val Thr Lys Gly Thr Gly Arg Arg Pro 
    50                  55                  60                  


Gly Ala His Ser Gly Arg Glu Pro Gly Cys Thr Pro Gly Cys Cys Phe 
65                  70                  75                  80  


Val Arg Leu Ser Thr Arg Pro Pro Ala Pro Thr Pro Pro Ala Ala Ser 
                85                  90                  95      


Arg Cys Gly Ala Gly Asn His Thr Pro His Trp Ala Gly His Ser Leu 
            100                 105                 110         


Asp Pro His Val Leu Phe Lys Ser Arg Leu Gly Asn Cys Leu Asn Val 
        115                 120                 125             


Val Trp Asp Thr Arg Pro His His Ile Asp Glu Arg Thr Asn Lys Asn 
    130                 135                 140                 


Ile Ser Ser Leu Pro Ser Phe Glu Leu Lys Trp His Ile Lys Thr Cys 
145                 150                 155                 160 


His Gly Phe Ser Leu Gly Leu Glu Thr Ser Phe Leu His Pro Ala Cys 
                165                 170                 175     


Arg Gln Pro Leu Gly Pro Ala Arg Ala Pro Gly Phe Ser Ala Thr His 
            180                 185                 190         


Thr Leu Pro Thr Leu Leu Trp Gly Pro Ala Phe Val Gly Ser Ser Gln 
        195                 200                 205             


Pro Ser Ala Pro Ala Gln Gly Ser Pro Thr Ile Gly Leu Gly Pro Pro 
    210                 215                 220                 


Pro Ser Leu Gly Gly Cys Ser Tyr Glu Cys Arg His Trp Ala His Trp 
225                 230                 235                 240 


Thr Cys Cys 
            

<210>  3463
<211>  2324
<212>  DNA
<213>  Homo sapiens

<400>  3463
agatggctcg tgcgcaggtg cgtgctagga gcgcggctcg tcagggcagg ctgctctgca     60

gggcaggcga tccggggctc gcctccgcgc ggcattcagc gcgcaggcgc gagctggccg    120

cctcacacgg agtcggcttg ttaagtgcgc acgcgcggga gtttctggca gaaagcaggc    180

gagcctgggc cggcgcgggg ccttgtggga gggcttaagg aagtaaaatg gcggacctgg    240

cgaacgaaga aaagcctgcc attgctccgc ccgtctttgt gtttcagaag gataaaggac    300

aaaagaggtc agctggcggc tccagtcctg aaggcggaga agattctgac agagaagatg    360

gaaattactg ccctcctgtc aagcgagaaa gaacatcctc tttaacccag ttcccaccct    420

cacagtcaga ggaaaggagc agtggcttcc ggttgaagcc accaacgctg atccacggcc    480

aagcccccag cgcaggtctg ccaagccaga agcccaagga gcagcagcgg agcgtgcttc    540

gcccggcagt gttacaagct ccgcagccaa aggcgctgtc ccagactgtc cccagcagtg    600

gcaccaacgg ggtcagcctc ccagcagact gcacgggggc agtgcccgca gcatcccctg    660

acactgctgc atggagaagt ccttccgaag ctgccgatga ggtgtgtgca cttgaggaga    720

aagagcccca gaaaaatgag tccagcaatg cctctgaaga ggaagcctgt gagaaaaaag    780

accccgccac acagcaagcc tttgtatttg ggcagaactt gagggacaga gttaagctga    840

taaatgagag cgtggacgaa gccgacatgg agaatgctgg acaccccagc gcagacacgc    900

caaccgcaac gaactatttc ctccagtata tcagttccag tttagagaac tcaaccaata    960

gtgccgacgc ctccagcaac aaatttgtat ttggccagaa catgagcgag cgagttttga   1020

gccccccaaa attaaacgag gtcagttcag atgccaacag ggaaaatgca gctgccgagt   1080

cagggtctga gtcctcgtcc caggaggcca cccctgagaa agagtccctg gctgagtcgg   1140

cagccgccta caccaaggca acagcgcgga agtgtttgtt ggaaaaagtg gaagtcatca   1200

ccggggagga ggcggagagc aatgtgttac agatgcagtg caagctgttt gtctttgaca   1260

agacctcaca gtcctgggtg gagagaggcc gggggctgct cagactcaat gacatggcgt   1320

ccaccgatga cggcacacta cagtcccgac tagtgatgcg gacccagggg agcctgcgac   1380

tgatcctcaa caccaagctg tgggcccaga tgcagatcga caaggccagc gagaagagca   1440

ttcgcatcac agccatggac accgaggacc agggcgtgaa ggtcttcctg atctcggcca   1500

gctccaagga cacaggtcag ttgtatgcag ccctgcacca ccgcatcctg gccctgcgca   1560

gccgcgtgga gcaggagcag gaggccaaga tgcccgcgcc tgagcctggg gcagccccat   1620

ccaacgagga ggacgacagc gacgatgacg atgtcctggc tccttcaggg gccaccgcag   1680

ctggtgctgg tgacgaaggg gacgggcaga cgaccgggag cacatagcgg ccgggagccc   1740

ggctgcacac caggctgctg ctttgtccgt ctatccaccc gcccacccgc ccccacccca   1800

ccggcagcgt ccaggtgcgg ggccgggaac cacacacccc actgggccgg ccacagtctg   1860

gacccgcacg tcctgttcaa aagcagactc gggaactgcc tgaatgtggt ttgggacacg   1920

agacctcatc atattgatga gcgaacaaac aagaacattt cctccctccc ctcctttgaa   1980

ttgaaatggc acattaagac ttgtcacggc ttctcactgg gactggagac ctcgttcctt   2040

caccccgcgt gtcgccagcc tctgggtcca gccagagccc ctggcttctc cgccacccac   2100

acccttccca ccctgctgtg gggccctgcc tttgtgggga gcagccagcc ctctgcccct   2160

gcccagggct ccccaactat aggcctggga cccccgccca gcttgggggg ctgctcgtac   2220

gagtgtagac actgggccca ttggacgtgc tgttaactac tatcttcatt tcccacttcc   2280

cctctctgat tgggggtgta tattttacat ctttttttct tttt                    2324


<210>  3464
<211>  499
<212>  PRT
<213>  Homo sapiens

<400>  3464


Met Ala Asp Leu Ala Asn Glu Glu Lys Pro Ala Ile Ala Pro Pro Val 
1               5                   10                  15      


Phe Val Phe Gln Lys Asp Lys Gly Gln Lys Arg Ser Ala Gly Gly Ser 
            20                  25                  30          


Ser Pro Glu Gly Gly Glu Asp Ser Asp Arg Glu Asp Gly Asn Tyr Cys 
        35                  40                  45              


Pro Pro Val Lys Arg Glu Arg Thr Ser Ser Leu Thr Gln Phe Pro Pro 
    50                  55                  60                  


Ser Gln Ser Glu Glu Arg Ser Ser Gly Phe Arg Leu Lys Pro Pro Thr 
65                  70                  75                  80  


Leu Ile His Gly Gln Ala Pro Ser Ala Gly Leu Pro Ser Gln Lys Pro 
                85                  90                  95      


Lys Glu Gln Gln Arg Ser Val Leu Arg Pro Ala Val Leu Gln Ala Pro 
            100                 105                 110         


Gln Pro Lys Ala Leu Ser Gln Thr Val Pro Ser Ser Gly Thr Asn Gly 
        115                 120                 125             


Val Ser Leu Pro Ala Asp Cys Thr Gly Ala Val Pro Ala Ala Ser Pro 
    130                 135                 140                 


Asp Thr Ala Ala Trp Arg Ser Pro Ser Glu Ala Ala Asp Glu Val Cys 
145                 150                 155                 160 


Ala Leu Glu Glu Lys Glu Pro Gln Lys Asn Glu Ser Ser Asn Ala Ser 
                165                 170                 175     


Glu Glu Glu Ala Cys Glu Lys Lys Asp Pro Ala Thr Gln Gln Ala Phe 
            180                 185                 190         


Val Phe Gly Gln Asn Leu Arg Asp Arg Val Lys Leu Ile Asn Glu Ser 
        195                 200                 205             


Val Asp Glu Ala Asp Met Glu Asn Ala Gly His Pro Ser Ala Asp Thr 
    210                 215                 220                 


Pro Thr Ala Thr Asn Tyr Phe Leu Gln Tyr Ile Ser Ser Ser Leu Glu 
225                 230                 235                 240 


Asn Ser Thr Asn Ser Ala Asp Ala Ser Ser Asn Lys Phe Val Phe Gly 
                245                 250                 255     


Gln Asn Met Ser Glu Arg Val Leu Ser Pro Pro Lys Leu Asn Glu Val 
            260                 265                 270         


Ser Ser Asp Ala Asn Arg Glu Asn Ala Ala Ala Glu Ser Gly Ser Glu 
        275                 280                 285             


Ser Ser Ser Gln Glu Ala Thr Pro Glu Lys Glu Ser Leu Ala Glu Ser 
    290                 295                 300                 


Ala Ala Ala Tyr Thr Lys Ala Thr Ala Arg Lys Cys Leu Leu Glu Lys 
305                 310                 315                 320 


Val Glu Val Ile Thr Gly Glu Glu Ala Glu Ser Asn Val Leu Gln Met 
                325                 330                 335     


Gln Cys Lys Leu Phe Val Phe Asp Lys Thr Ser Gln Ser Trp Val Glu 
            340                 345                 350         


Arg Gly Arg Gly Leu Leu Arg Leu Asn Asp Met Ala Ser Thr Asp Asp 
        355                 360                 365             


Gly Thr Leu Gln Ser Arg Leu Val Met Arg Thr Gln Gly Ser Leu Arg 
    370                 375                 380                 


Leu Ile Leu Asn Thr Lys Leu Trp Ala Gln Met Gln Ile Asp Lys Ala 
385                 390                 395                 400 


Ser Glu Lys Ser Ile Arg Ile Thr Ala Met Asp Thr Glu Asp Gln Gly 
                405                 410                 415     


Val Lys Val Phe Leu Ile Ser Ala Ser Ser Lys Asp Thr Gly Gln Leu 
            420                 425                 430         


Tyr Ala Ala Leu His His Arg Ile Leu Ala Leu Arg Ser Arg Val Glu 
        435                 440                 445             


Gln Glu Gln Glu Ala Lys Met Pro Ala Pro Glu Pro Gly Ala Ala Pro 
    450                 455                 460                 


Ser Asn Glu Glu Asp Asp Ser Asp Asp Asp Asp Val Leu Ala Pro Ser 
465                 470                 475                 480 


Gly Ala Thr Ala Ala Gly Ala Gly Asp Glu Gly Asp Gly Gln Thr Thr 
                485                 490                 495     


Gly Ser Thr 
            

<210>  3465
<211>  397
<212>  DNA
<213>  Homo sapiens

<400>  3465
cgaggaggac gacagcgacg atgacgatgt cctggctcct tcaggggcca ccgcagctgg     60

tgctggtgac gaaggggacg ggcagacgac cgggagcaca tagcggccgg gagcccggct    120

gcacaccagg ctgctgcttt gtccgtctat ccacccgccc acccgccccc accccaccgg    180

cagcgtccag gtgcggggcc gggaaccaca caccccactg ggccggccac agtctggacc    240

cgcacgtcct gttcaaaagc agactcggga actgcctgaa tgtggtttgg gacacgagac    300

ctcatcatat tgatgagcga acaaacaaga acatttcctc cctcccctcc tttgaattga    360

aatggcacat taagacttgt cacggcttct cactggg                             397


<210>  3466
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  3466


Met Thr Met Ser Trp Leu Leu Gln Gly Pro Pro Gln Leu Val Leu Val 
1               5                   10                  15      


Thr Lys Gly Thr Gly Arg Arg Pro Gly Ala His Ser Gly Arg Glu Pro 
            20                  25                  30          


Gly Cys Thr Pro Gly Cys Cys Phe Val Arg Leu Ser Thr Arg Pro Pro 
        35                  40                  45              


Ala Pro Thr Pro Pro Ala Ala Ser Arg Cys Gly Ala Gly Asn His Thr 
    50                  55                  60                  


Pro His Trp Ala Gly His Ser Leu Asp Pro His Val Leu Phe Lys Ser 
65                  70                  75                  80  


Arg Leu Gly Asn Cys Leu Asn Val Val Trp Asp Thr Arg Pro His His 
                85                  90                  95      


Ile Asp Glu Arg Thr Asn Lys Asn Ile Ser Ser Leu Pro Ser Phe Glu 
            100                 105                 110         


Leu Lys Trp His Ile Lys Thr Cys His Gly Phe Ser 
        115                 120                 

<210>  3467
<211>  429
<212>  DNA
<213>  Homo sapiens

<400>  3467
tgtgttccag atgcagtgca agctgtttgt ctttgacaag acctcacagt cctgggtgga     60

gagaggccgg gggctgctca gactcaatga catggcgtcc accgatggga cgggcagacg    120

accgggagca catagcggcc gggagcccgg ctgcacacca ggctgctgct ttgtccgtct    180

atccacccgc ccacccgccc ccaccccacc ggcagcgtcc aggtgcgggg ccgggaacca    240

cacaccccac tgggccggcc acagtctgga cccgcacgtc ctgttcaaaa gcagactcgg    300

gaactgcctg aatgtggttt gggacacgag acctcatcat attgatgagc gaacaaacaa    360

gaacatttcc tccctcccct cctttgaatt gaaatggcac attaagactt gtcacggctt    420

ctcactggg                                                            429


<210>  3468
<211>  138
<212>  PRT
<213>  Homo sapiens

<400>  3468


Met Gln Cys Lys Leu Phe Val Phe Asp Lys Thr Ser Gln Ser Trp Val 
1               5                   10                  15      


Glu Arg Gly Arg Gly Leu Leu Arg Leu Asn Asp Met Ala Ser Thr Asp 
            20                  25                  30          


Gly Thr Gly Arg Arg Pro Gly Ala His Ser Gly Arg Glu Pro Gly Cys 
        35                  40                  45              


Thr Pro Gly Cys Cys Phe Val Arg Leu Ser Thr Arg Pro Pro Ala Pro 
    50                  55                  60                  


Thr Pro Pro Ala Ala Ser Arg Cys Gly Ala Gly Asn His Thr Pro His 
65                  70                  75                  80  


Trp Ala Gly His Ser Leu Asp Pro His Val Leu Phe Lys Ser Arg Leu 
                85                  90                  95      


Gly Asn Cys Leu Asn Val Val Trp Asp Thr Arg Pro His His Ile Asp 
            100                 105                 110         


Glu Arg Thr Asn Lys Asn Ile Ser Ser Leu Pro Ser Phe Glu Leu Lys 
        115                 120                 125             


Trp His Ile Lys Thr Cys His Gly Phe Ser 
    130                 135             

<210>  3469
<211>  2929
<212>  DNA
<213>  Homo sapiens

<400>  3469
gtcgcccagg ctggagtgca gtggtacagt cgtaactcaa ctgtaacctc aagctcccag     60

gctcaagtga tcttcccacc tctgcctcct gagtagctgg gactacaggc atgtaccacc    120

atgcctggct aagtttttaa ttttttgtag agttagggtc ttgcagtgtt gcccaggctg    180

atctcaaact cttgggctca tgcagtcctc ctgcctcagc ctcccaaagc actgggatta    240

caggcatgag ccactgcacc cggccctaac attgttttat agttttatct tgtgaaatgt    300

attcccaagt attttattcc ttttggtgtt attgtaaatg gaattatttt cttaattttg    360

cttttgggtc attcactgct agtgttagaa acacaatcga tttttgtata ttgatcttgt    420

gtcctgtagc ttgacaaggg ggtgaagctt agcacaaacg cagggctacc tccaggagcc    480

ataatgccac agtctctgtg ccttgcccag gaacaggctt gcctgcctga gtcacaggcc    540

ttttatgaca atccttcctg ttgtggatca gattagacca ccatccccac tccctgtatg    600

ggcacagttg ccaagacaca cagatgaagg ggtccatgtg gacaggtggc tgggcgaggc    660

tgggctctcg agccatccca ggagctcgtg ggcattcacc tttccctcta gttttgtgaa    720

tttgtcagcc cggactctgg cccaggggga gctggcctcc tccacggtgg ccaggagtgc    780

cccctcactg agacgggaag ctccgcaggc acatctggaa aggggaggca ggctcactgt    840

gtgccacctt tgaccttttc atcacaaaaa cctgtctcac ttcccagaca tctgtagtgg    900

tgccaaggtt cttcctggcc acagccgcat cctctgacag acaagccttc taggaaaggg    960

aagtggggcc tgagcgcctg tgttccgtgg ctccctgaca ttctccagag ccaggtacag   1020

ggccgctgag cagctcggct cctgagcctg cagcaggtca tagacagctg ggagggcggc   1080

tgacgcccca cctgccccca tggtcagcag ctggcccaag agccatcgtt cctcctgccc   1140

ttgtctctcc cctcctccag gcgccttcca ggcctgctga tcggacgaga cttctgttgt   1200

aatttggaaa tgttctccct ggttctccag gcccgaagtc actgaggcca agaccatagt   1260

cctctcctgc ccttgccccc caggcccagc cccagcccag gcaggcctgc tgttgatatt   1320

ttgtcttgtg cttttagagg aaaggagcag tggcttccgg ttgaagccac caacgctgat   1380

ccacggccaa gcccccagcg caggtctgcc aagccagaag cccaaggagc agcagcggag   1440

cgtgcttcgc ccggcagtgt tacaagctcc gcagccaaag gcgctgtccc agactgtccc   1500

cagcagtggc accaacgggg tcagcctccc agcagactgc acgggggcag tgcccgcagc   1560

atcccctgac actgctgcat ggagaagtcc ttccgaagct gccgatgagg tgtgtgcact   1620

tgaggagaaa gagccccaga aaaatgagtc cagcaatgcc tctgaagagg aagcctgtga   1680

gaaaaaagac cccgccacac agcaagcctt tgtatttggg cagaacttga gggacagagt   1740

taagctgata aatgagagcg tggacgaagc cgacatggag aatgctggac accccagcgc   1800

agacacgcca accgcaacga actatttcct ccagtatatc agttccagtt tagagaactc   1860

aaccaatagt gccgacgcct ccagcaacaa atttgtattt ggccagaaca tgagcgagcg   1920

agttttgagc cccccaaaat taaacgaggt cagttcagat gccaacaggg aaaatgcagc   1980

tgccgagtca gggtctgagt cctcgtccca ggaggccacc cctgagaaag agtccctggc   2040

tgagtcggca gccgcctaca ccaaggcaac agcgcggaag tgtttgttgg aaaaagtgga   2100

agtcatcacc ggggaggagg cggagagcaa tgtgttacag atgcagtgca agctgtttgt   2160

ctttgacaag acctcacagt cctgggtgga gagaggccgg gggctgctca gactcaatga   2220

catggcgtcc accgatgacg gcacactaca gtcccgacta gtgatgcgga cccaggggag   2280

cctgcgactg atcctcaaca ccaagctgtg ggcccagatg cagatcgaca aggccagcga   2340

gaagagcatt cgcatcacag ccatggacac cgaggaccag ggcgtgaagg tcttcctgat   2400

ctcggccagc tccaaggaca caggtcagtt gtatgcagcc ctgcaccacc gcatcctggc   2460

cctgcgcagc cgcgtggagc aggagcagga ggccaagatg cccgcgcctg agcctggggc   2520

agccccatcc aacgaggagg acgacagcga cgatgacgat gtcctggctc cttcaggggc   2580

caccgcagct ggtgctggtg acgaagggga cgggcagacg accgggagca catagcggcc   2640

gggagcccgg ctgcacacca ggctgctgct ttgtccgtct atccacccgc ccacccgccc   2700

ccaccccacc ggcagcgtcc aggtgcgggg ccgggaacca cacaccccac tgggccggcc   2760

acagtctgga cccgcacgtc ctgttcaaaa gcagactcgg gaactgcctg aatgtggttt   2820

gggacacgag acctcatcat attgatgagc gaacaaacaa gaacatttcc tccctcccct   2880

cctttgaatt gaaatggcac attaagactt gtcacggctt ctcactggg               2929


<210>  3470
<211>  286
<212>  PRT
<213>  Homo sapiens

<400>  3470


Met Glu Asn Ala Gly His Pro Ser Ala Asp Thr Pro Thr Ala Thr Asn 
1               5                   10                  15      


Tyr Phe Leu Gln Tyr Ile Ser Ser Ser Leu Glu Asn Ser Thr Asn Ser 
            20                  25                  30          


Ala Asp Ala Ser Ser Asn Lys Phe Val Phe Gly Gln Asn Met Ser Glu 
        35                  40                  45              


Arg Val Leu Ser Pro Pro Lys Leu Asn Glu Val Ser Ser Asp Ala Asn 
    50                  55                  60                  


Arg Glu Asn Ala Ala Ala Glu Ser Gly Ser Glu Ser Ser Ser Gln Glu 
65                  70                  75                  80  


Ala Thr Pro Glu Lys Glu Ser Leu Ala Glu Ser Ala Ala Ala Tyr Thr 
                85                  90                  95      


Lys Ala Thr Ala Arg Lys Cys Leu Leu Glu Lys Val Glu Val Ile Thr 
            100                 105                 110         


Gly Glu Glu Ala Glu Ser Asn Val Leu Gln Met Gln Cys Lys Leu Phe 
        115                 120                 125             


Val Phe Asp Lys Thr Ser Gln Ser Trp Val Glu Arg Gly Arg Gly Leu 
    130                 135                 140                 


Leu Arg Leu Asn Asp Met Ala Ser Thr Asp Asp Gly Thr Leu Gln Ser 
145                 150                 155                 160 


Arg Leu Val Met Arg Thr Gln Gly Ser Leu Arg Leu Ile Leu Asn Thr 
                165                 170                 175     


Lys Leu Trp Ala Gln Met Gln Ile Asp Lys Ala Ser Glu Lys Ser Ile 
            180                 185                 190         


Arg Ile Thr Ala Met Asp Thr Glu Asp Gln Gly Val Lys Val Phe Leu 
        195                 200                 205             


Ile Ser Ala Ser Ser Lys Asp Thr Gly Gln Leu Tyr Ala Ala Leu His 
    210                 215                 220                 


His Arg Ile Leu Ala Leu Arg Ser Arg Val Glu Gln Glu Gln Glu Ala 
225                 230                 235                 240 


Lys Met Pro Ala Pro Glu Pro Gly Ala Ala Pro Ser Asn Glu Glu Asp 
                245                 250                 255     


Asp Ser Asp Asp Asp Asp Val Leu Ala Pro Ser Gly Ala Thr Ala Ala 
            260                 265                 270         


Gly Ala Gly Asp Glu Gly Asp Gly Gln Thr Thr Gly Ser Thr 
        275                 280                 285     

<210>  3471
<211>  1659
<212>  DNA
<213>  Homo sapiens

<400>  3471
gcctgggccg gcgcggggcc ttgtgggagg gcttaaggaa gtaaaatggc ggacctggcg     60

aacgaagagg aaaggagcag tggcttccgg ttgaagccac caacgctgat ccacggccaa    120

gcccccagcg caggtctgcc aagccagaag cccaaggagc agcagcggag cgtgcttcgc    180

ccggcagtgt tacaagctcc gcagccaaag gcgctgtccc agactgtccc cagcagtggc    240

accaacgggg tcagcctccc agcagactgc acgggggcag tgcccgcagc atcccctgac    300

actgctgcat ggagaagtcc ttccgaagct gccgatgagg tgtgtgcact tgaggagaaa    360

gagccccaga aaaatgagtc cagcaatgcc tctgaagagg aagcctgtga gaaaaaagac    420

cccgccacac agcaagcctt tgtatttggg cagaacttga gggacagagt taagctgata    480

aatgagagcg tggacgaagc cgacatggag aatgctggac accccagcgc agacacgcca    540

accgcaacga actatttcct ccagtatatc agttccagtt tagagaactc aaccaatagt    600

gccgacgcct ccagcaacaa atttgtattt ggccagaaca tgagcgagcg agttttgagc    660

cccccaaaat taaacgaggt cagttcagat gccaacaggg aaaatgcagc tgccgagtca    720

gggtctgagt cctcgtccca ggaggccacc cctgagaaag agtccctggc tgagtcggca    780

gccgcctaca ccaaggcaac agcgcggaag tgtttgttgg aaaaagtgga agtcatcacc    840

ggggaggagg cggagagcaa tgtgttacag atgcagtgca agctgtttgt ctttgacaag    900

acctcacagt cctgggtgga gagaggccgg gggctgctca gactcaatga catggcgtcc    960

accgatgacg gcacactaca gtcccgacta gtgatgcgga cccaggggag cctgcgactg   1020

atcctcaaca ccaagctgtg ggcccagatg cagatcgaca aggccagcga gaagagcatt   1080

cgcatcacag ccatggacac cgaggaccag ggcgtgaagg tcttcctgat ctcggccagc   1140

tccaaggaca caggtcagtt gtatgcagcc ctgcaccacc gcatcctggc cctgcgcagc   1200

cgcgtggagc aggagcagga ggccaagatg cccgcgcctg agcctggggc agccccatcc   1260

aacgaggagg acgacagcga cgatgacgat gtcctggctc cttcaggggc caccgcagct   1320

ggtgctggtg acgaagggga cgggcagacg accgggagca catagcggcc gggagcccgg   1380

ctgcacacca ggctgctgct ttgtccgtct atccacccgc ccacccgccc ccaccccacc   1440

ggcagcgtcc aggtgcgggg ccgggaacca cacaccccac tgggccggcc acagtctgga   1500

cccgcacgtc ctgttcaaaa gcagactcgg gaactgcctg aatgtggttt gggacacgag   1560

acctcatcat attgatgagc gaacaaacaa gaacatttcc tccctcccct cctttgaatt   1620

gaaatggcac attaagactt gtcacggctt ctcactggg                          1659


<210>  3472
<211>  439
<212>  PRT
<213>  Homo sapiens

<400>  3472


Met Ala Asp Leu Ala Asn Glu Glu Glu Arg Ser Ser Gly Phe Arg Leu 
1               5                   10                  15      


Lys Pro Pro Thr Leu Ile His Gly Gln Ala Pro Ser Ala Gly Leu Pro 
            20                  25                  30          


Ser Gln Lys Pro Lys Glu Gln Gln Arg Ser Val Leu Arg Pro Ala Val 
        35                  40                  45              


Leu Gln Ala Pro Gln Pro Lys Ala Leu Ser Gln Thr Val Pro Ser Ser 
    50                  55                  60                  


Gly Thr Asn Gly Val Ser Leu Pro Ala Asp Cys Thr Gly Ala Val Pro 
65                  70                  75                  80  


Ala Ala Ser Pro Asp Thr Ala Ala Trp Arg Ser Pro Ser Glu Ala Ala 
                85                  90                  95      


Asp Glu Val Cys Ala Leu Glu Glu Lys Glu Pro Gln Lys Asn Glu Ser 
            100                 105                 110         


Ser Asn Ala Ser Glu Glu Glu Ala Cys Glu Lys Lys Asp Pro Ala Thr 
        115                 120                 125             


Gln Gln Ala Phe Val Phe Gly Gln Asn Leu Arg Asp Arg Val Lys Leu 
    130                 135                 140                 


Ile Asn Glu Ser Val Asp Glu Ala Asp Met Glu Asn Ala Gly His Pro 
145                 150                 155                 160 


Ser Ala Asp Thr Pro Thr Ala Thr Asn Tyr Phe Leu Gln Tyr Ile Ser 
                165                 170                 175     


Ser Ser Leu Glu Asn Ser Thr Asn Ser Ala Asp Ala Ser Ser Asn Lys 
            180                 185                 190         


Phe Val Phe Gly Gln Asn Met Ser Glu Arg Val Leu Ser Pro Pro Lys 
        195                 200                 205             


Leu Asn Glu Val Ser Ser Asp Ala Asn Arg Glu Asn Ala Ala Ala Glu 
    210                 215                 220                 


Ser Gly Ser Glu Ser Ser Ser Gln Glu Ala Thr Pro Glu Lys Glu Ser 
225                 230                 235                 240 


Leu Ala Glu Ser Ala Ala Ala Tyr Thr Lys Ala Thr Ala Arg Lys Cys 
                245                 250                 255     


Leu Leu Glu Lys Val Glu Val Ile Thr Gly Glu Glu Ala Glu Ser Asn 
            260                 265                 270         


Val Leu Gln Met Gln Cys Lys Leu Phe Val Phe Asp Lys Thr Ser Gln 
        275                 280                 285             


Ser Trp Val Glu Arg Gly Arg Gly Leu Leu Arg Leu Asn Asp Met Ala 
    290                 295                 300                 


Ser Thr Asp Asp Gly Thr Leu Gln Ser Arg Leu Val Met Arg Thr Gln 
305                 310                 315                 320 


Gly Ser Leu Arg Leu Ile Leu Asn Thr Lys Leu Trp Ala Gln Met Gln 
                325                 330                 335     


Ile Asp Lys Ala Ser Glu Lys Ser Ile Arg Ile Thr Ala Met Asp Thr 
            340                 345                 350         


Glu Asp Gln Gly Val Lys Val Phe Leu Ile Ser Ala Ser Ser Lys Asp 
        355                 360                 365             


Thr Gly Gln Leu Tyr Ala Ala Leu His His Arg Ile Leu Ala Leu Arg 
    370                 375                 380                 


Ser Arg Val Glu Gln Glu Gln Glu Ala Lys Met Pro Ala Pro Glu Pro 
385                 390                 395                 400 


Gly Ala Ala Pro Ser Asn Glu Glu Asp Asp Ser Asp Asp Asp Asp Val 
                405                 410                 415     


Leu Ala Pro Ser Gly Ala Thr Ala Ala Gly Ala Gly Asp Glu Gly Asp 
            420                 425                 430         


Gly Gln Thr Thr Gly Ser Thr 
        435                 

<210>  3473
<211>  871
<212>  DNA
<213>  Homo sapiens

<400>  3473
gcagaaagca ggcgagcctg ggccggcgcg gggccttgtg ggagggctta aggaagtaaa     60

atggcggacc tggcgaacga agatgcagtg caagctgttt gtctttgaca agacctcaca    120

gtcctgggtg gagagaggcc gggggctgct cagactcaat gacatggcgt ccaccgatga    180

cggcacacta cagtcccgac tagtgatgcg gacccagggg agcctgcgac tgatcctcaa    240

caccaagctg tgggcccaga tgcagatcga caaggccagc gagaagagca ttcgcatcac    300

agccatggac accgaggacc agggcgtgaa ggtcttcctg atctcggcca gctccaagga    360

cacaggtcag ttgtatgcag ccctgcacca ccgcatcctg gccctgcgca gccgcgtgga    420

gcaggagcag gaggccaaga tgcccgcgcc tgagcctggg gcagccccat ccaacgagga    480

ggacgacagc gacgatgacg atgtcctggc tccttcaggg gccaccgcag ctggtgctgg    540

tgacgaaggg gacgggcaga cgaccgggag cacatagcgg ccgggagccc ggctgcacac    600

caggctgctg ctttgtccgt ctatccaccc gcccacccgc ccccacccca ccggcagcgt    660

ccaggtgcgg ggccgggaac cacacacccc actgggccgg ccacagtctg gacccgcacg    720

tcctgttcaa aagcagactc gggaactgcc tgaatgtggt ttgggacacg agacctcatc    780

atattgatga gcgaacaaac aagaacattt cctccctccc ctcctttgaa ttgaaatggc    840

acattaagac ttgtcacggc ttctcactgg g                                   871


<210>  3474
<211>  164
<212>  PRT
<213>  Homo sapiens

<400>  3474


Met Gln Cys Lys Leu Phe Val Phe Asp Lys Thr Ser Gln Ser Trp Val 
1               5                   10                  15      


Glu Arg Gly Arg Gly Leu Leu Arg Leu Asn Asp Met Ala Ser Thr Asp 
            20                  25                  30          


Asp Gly Thr Leu Gln Ser Arg Leu Val Met Arg Thr Gln Gly Ser Leu 
        35                  40                  45              


Arg Leu Ile Leu Asn Thr Lys Leu Trp Ala Gln Met Gln Ile Asp Lys 
    50                  55                  60                  


Ala Ser Glu Lys Ser Ile Arg Ile Thr Ala Met Asp Thr Glu Asp Gln 
65                  70                  75                  80  


Gly Val Lys Val Phe Leu Ile Ser Ala Ser Ser Lys Asp Thr Gly Gln 
                85                  90                  95      


Leu Tyr Ala Ala Leu His His Arg Ile Leu Ala Leu Arg Ser Arg Val 
            100                 105                 110         


Glu Gln Glu Gln Glu Ala Lys Met Pro Ala Pro Glu Pro Gly Ala Ala 
        115                 120                 125             


Pro Ser Asn Glu Glu Asp Asp Ser Asp Asp Asp Asp Val Leu Ala Pro 
    130                 135                 140                 


Ser Gly Ala Thr Ala Ala Gly Ala Gly Asp Glu Gly Asp Gly Gln Thr 
145                 150                 155                 160 


Thr Gly Ser Thr 
                

<210>  3475
<211>  2021
<212>  DNA
<213>  Homo sapiens

<400>  3475
agatggctcg tgcgcaggtg cgtgctagga gcgcggctcg tcagggcagg ctgctctgca     60

gggcaggcga tccggggctc gcctccgcgc ggcattcagc gcgcaggcgc gagctggccg    120

cctcacacgg agtcggcttg ttaagtgcgc acgcgcggga gtttctggca gaaagcaggc    180

gagcctgggc cggcgcgggg ccttgtggga gggcttaagg aagtaaaatg gcggacctgg    240

cgaacgaaga aaagcctgcc attgctccgc ccgtctttgt gtttcagaag gataaaggac    300

aaaagaggtc agctggcggc tccagtcctg aaggcggaga agattctgac agagaagatg    360

gaaattactg ccctcctgtc aagcgagaaa gaacatcctc tttaacccag ttcccaccct    420

cacagtcaga ggaaaggagc agtggcttcc ggttgaagcc accaacgctg atccacggcc    480

aagcccccag cgcaggtctg ccaagccaga agcccaagga gcagcagcgg agcgtgcttc    540

gcccggcagt gttacaagct ccgcagccaa aggcgctgtc ccagactgtc cccagcagtg    600

gcaccaacgg ggtcagcctc ccagcagact gcacgggggc agtgcccgca gcatcccctg    660

acactgctgc atggagaagt ccttccgaag ctgccgatga ggtgtgtgca cttgaggaga    720

aagagcccca gaaaaatgag tccagcaatg cctctgaaga ggaagcctgt gagaaaaaag    780

accccgccac acagcaagcc tttgtatttg ggcagaactt gagggacaga gttaagctga    840

taaatgagag cgtggacgaa gccgacatgg agaatgctgg acaccccagc gcagacacgc    900

caaccgcaac gaactatttc ctccagtata tcagttccag tttagagaac tcaaccaata    960

gtgccgacgc ctccagcaac aaatttgtat ttggccagaa catgagcgag cgagttttga   1020

gccccccaaa attaaacgag gtcagttcag atgccaacag ggaaaatgca gctgccgagt   1080

cagggtctga gtcctcgtcc caggaggcca cccctgagaa agagtccctg gctgagtcgg   1140

cagccgccta caccaaggca acagcgcgga agtgtttgtt ggaaaaagtg gaagtcatca   1200

ccggggagga ggcggagagc aatgtgttac agatgcagtg caagctgttt gtctttgaca   1260

agacctcaca gtcctgggtg gagagaggcc gggggctgct cagactcaat gacatggcgt   1320

ccaccgatga cggcacacta cagtcccgac tagtgatgcg gacccagggg agcctgcgac   1380

tgatcctcaa caccaagctg tgggcccaga tgcagatcga caaggccagc gagaagagca   1440

ttcgcatcac agccatggac accgaggacc agggcgtgaa ggtcttcctg atctcggcca   1500

gctccaagga cacaggtcag ttgtatgcag ccctgcacca ccgcatcctg gccctgcgca   1560

gccgcgtgga gcaggagcag gaggccaaga tgcccgcgcc tgagcctggg gcagccccat   1620

ccaacgagga ggacgacagc gacgatgacg atgtcctggc tccttcaggg gccaccgcag   1680

ctggtgctgg tgacgaaggg gacgggcaga cgaccgggag cacatagcgg ccgggagccc   1740

ggctgcacac caggctgctg ctttgtccgt ctatccaccc gcccacccgc ccccacccca   1800

ccggcagcgt ccaggtgcgg ggccgggaac cacacacccc actgggccgg ccacagtctg   1860

gacccgcacg tcctgttcaa aagcagactc gggaactgcc tgaatgtggt ttgggacacg   1920

agacctcatc atattgatga gcgaacaaac aagaacattt cctccctccc ctcctttgaa   1980

ttgaaatggc acattaagac ttgtcacggc ttctcactgg g                       2021


<210>  3476
<211>  499
<212>  PRT
<213>  Homo sapiens

<400>  3476


Met Ala Asp Leu Ala Asn Glu Glu Lys Pro Ala Ile Ala Pro Pro Val 
1               5                   10                  15      


Phe Val Phe Gln Lys Asp Lys Gly Gln Lys Arg Ser Ala Gly Gly Ser 
            20                  25                  30          


Ser Pro Glu Gly Gly Glu Asp Ser Asp Arg Glu Asp Gly Asn Tyr Cys 
        35                  40                  45              


Pro Pro Val Lys Arg Glu Arg Thr Ser Ser Leu Thr Gln Phe Pro Pro 
    50                  55                  60                  


Ser Gln Ser Glu Glu Arg Ser Ser Gly Phe Arg Leu Lys Pro Pro Thr 
65                  70                  75                  80  


Leu Ile His Gly Gln Ala Pro Ser Ala Gly Leu Pro Ser Gln Lys Pro 
                85                  90                  95      


Lys Glu Gln Gln Arg Ser Val Leu Arg Pro Ala Val Leu Gln Ala Pro 
            100                 105                 110         


Gln Pro Lys Ala Leu Ser Gln Thr Val Pro Ser Ser Gly Thr Asn Gly 
        115                 120                 125             


Val Ser Leu Pro Ala Asp Cys Thr Gly Ala Val Pro Ala Ala Ser Pro 
    130                 135                 140                 


Asp Thr Ala Ala Trp Arg Ser Pro Ser Glu Ala Ala Asp Glu Val Cys 
145                 150                 155                 160 


Ala Leu Glu Glu Lys Glu Pro Gln Lys Asn Glu Ser Ser Asn Ala Ser 
                165                 170                 175     


Glu Glu Glu Ala Cys Glu Lys Lys Asp Pro Ala Thr Gln Gln Ala Phe 
            180                 185                 190         


Val Phe Gly Gln Asn Leu Arg Asp Arg Val Lys Leu Ile Asn Glu Ser 
        195                 200                 205             


Val Asp Glu Ala Asp Met Glu Asn Ala Gly His Pro Ser Ala Asp Thr 
    210                 215                 220                 


Pro Thr Ala Thr Asn Tyr Phe Leu Gln Tyr Ile Ser Ser Ser Leu Glu 
225                 230                 235                 240 


Asn Ser Thr Asn Ser Ala Asp Ala Ser Ser Asn Lys Phe Val Phe Gly 
                245                 250                 255     


Gln Asn Met Ser Glu Arg Val Leu Ser Pro Pro Lys Leu Asn Glu Val 
            260                 265                 270         


Ser Ser Asp Ala Asn Arg Glu Asn Ala Ala Ala Glu Ser Gly Ser Glu 
        275                 280                 285             


Ser Ser Ser Gln Glu Ala Thr Pro Glu Lys Glu Ser Leu Ala Glu Ser 
    290                 295                 300                 


Ala Ala Ala Tyr Thr Lys Ala Thr Ala Arg Lys Cys Leu Leu Glu Lys 
305                 310                 315                 320 


Val Glu Val Ile Thr Gly Glu Glu Ala Glu Ser Asn Val Leu Gln Met 
                325                 330                 335     


Gln Cys Lys Leu Phe Val Phe Asp Lys Thr Ser Gln Ser Trp Val Glu 
            340                 345                 350         


Arg Gly Arg Gly Leu Leu Arg Leu Asn Asp Met Ala Ser Thr Asp Asp 
        355                 360                 365             


Gly Thr Leu Gln Ser Arg Leu Val Met Arg Thr Gln Gly Ser Leu Arg 
    370                 375                 380                 


Leu Ile Leu Asn Thr Lys Leu Trp Ala Gln Met Gln Ile Asp Lys Ala 
385                 390                 395                 400 


Ser Glu Lys Ser Ile Arg Ile Thr Ala Met Asp Thr Glu Asp Gln Gly 
                405                 410                 415     


Val Lys Val Phe Leu Ile Ser Ala Ser Ser Lys Asp Thr Gly Gln Leu 
            420                 425                 430         


Tyr Ala Ala Leu His His Arg Ile Leu Ala Leu Arg Ser Arg Val Glu 
        435                 440                 445             


Gln Glu Gln Glu Ala Lys Met Pro Ala Pro Glu Pro Gly Ala Ala Pro 
    450                 455                 460                 


Ser Asn Glu Glu Asp Asp Ser Asp Asp Asp Asp Val Leu Ala Pro Ser 
465                 470                 475                 480 


Gly Ala Thr Ala Ala Gly Ala Gly Asp Glu Gly Asp Gly Gln Thr Thr 
                485                 490                 495     


Gly Ser Thr 
            

<210>  3477
<211>  1981
<212>  DNA
<213>  Homo sapiens

<400>  3477
agaaagcagg cgagcctggg ccggcgcggg gccttgtggg agggcttaag gaagtaaaat     60

ggcggacctg gcgaacgaag aaaagcctgc cattgctccg cccgtctttg tgtttcagaa    120

ggataaagga caaaagtccc ctgcagagca aaaaaacttg tcggattcgg gagaggagcc    180

tcggggggag gctgaggccc cccaccatgg cacgggtcac cccgagtcag ctggcgagca    240

tgccctagaa cctcctgccc ctgctggcgc ctcagccagc actcctccgc ctcccgctcc    300

tgaagcccag cttcctcctt ttccgcgaga actggcaggg aggtcagctg gcggctccag    360

tcctgaaggc ggagaagatt ctgacagaga agatggaaat tactgccctc ctgtcaagcg    420

agaaagaaca tcctctttaa cccagttccc accctcacag tcagaggaaa ggagcagtgg    480

cttccggttg aagccaccaa cgctgatcca cggccaagcc cccagcgcag gtctgccaag    540

ccagaagccc aaggagcagc agcggagcgt gcttcgcccg gcagtgttac aagctccgca    600

gccaaaggcg ctgtcccaga ctgtccccag cagtggcacc aacggggtca gcctcccagc    660

agactgcacg ggggcagtgc ccgcagcatc ccctgacact gctgcatgga gaagtccttc    720

cgaagctgcc gatgaggtgt gtgcacttga ggagaaagag ccccagaaaa atgagtccag    780

caatgcctct gaagaggaag cctgtgagaa aaaagacccc gccacacagc aagcctttgt    840

atttgggcag aacttgaggg acagagttaa gctgataaat gagagcgtgg acgaagccga    900

catggagaat gctggacacc ccagcgcaga cacgccaacc gcaacgaact atttcctcca    960

gtatatcagt tccagtttag agaactcaac caatagtgcc gacgcctcca gcaacaaatt   1020

tgtatttggc cagaacatga gcgagcgagt tttgagcccc ccaaaattaa acgaggtcag   1080

ttcagatgcc aacagggaaa atgcagctgc cgagtcaggg tctgagtcct cgtcccagga   1140

ggccacccct gagaaagagt ccctggctga gtcggcagcc gcctacacca aggcaacagc   1200

gcggaagtgt ttgttggaaa aagtggaagt catcaccggg gaggaggcgg agagcaatgt   1260

gttacagatg cagtgcaagc tgtttgtctt tgacaagacc tcacagtcct gggtggagag   1320

aggccggggg ctgctcagac tcaatgacat ggcgtccacc gatgacggca cactacagtc   1380

ccgactagtg atgcggaccc aggggagcct gcgactgatc ctcaacacca agctgtgggc   1440

ccagatgcag atcgacaagg ccagcgagaa gagcattcgc atcacagcca tggacaccga   1500

ggaccagggc gtgaaggtct tcctgatctc ggccagctcc aaggacacag gtcagttgta   1560

tgcagccctg caccaccgca tcctggccct gcgcagccgc gtggagcagg agcaggaggc   1620

caagatgccc gcgcctgagc ctggggcagc cccatccaac gaggaggacg acagcgacga   1680

tgacgatgtc ctggctcctt caggggccac cgcagctggt gctggtgacg aaggggacgg   1740

gcagacgacc gggagcacat agcggccggg agcccggctg cacaccaggc tgctgctttg   1800

tccgtctatc cacccgccca cccgccccca ccccaccggc agcgtccagg tgcggggccg   1860

ggaaccacac accccactgg gccggccaca gtctggaccc gcacgtcctg ttcaaaagca   1920

gactcgggaa ctgcctgaat gtggtttggg acacgagacc tcatcatatt gatgagcgaa   1980

c                                                                   1981


<210>  3478
<211>  567
<212>  PRT
<213>  Homo sapiens

<400>  3478


Met Ala Asp Leu Ala Asn Glu Glu Lys Pro Ala Ile Ala Pro Pro Val 
1               5                   10                  15      


Phe Val Phe Gln Lys Asp Lys Gly Gln Lys Ser Pro Ala Glu Gln Lys 
            20                  25                  30          


Asn Leu Ser Asp Ser Gly Glu Glu Pro Arg Gly Glu Ala Glu Ala Pro 
        35                  40                  45              


His His Gly Thr Gly His Pro Glu Ser Ala Gly Glu His Ala Leu Glu 
    50                  55                  60                  


Pro Pro Ala Pro Ala Gly Ala Ser Ala Ser Thr Pro Pro Pro Pro Ala 
65                  70                  75                  80  


Pro Glu Ala Gln Leu Pro Pro Phe Pro Arg Glu Leu Ala Gly Arg Ser 
                85                  90                  95      


Ala Gly Gly Ser Ser Pro Glu Gly Gly Glu Asp Ser Asp Arg Glu Asp 
            100                 105                 110         


Gly Asn Tyr Cys Pro Pro Val Lys Arg Glu Arg Thr Ser Ser Leu Thr 
        115                 120                 125             


Gln Phe Pro Pro Ser Gln Ser Glu Glu Arg Ser Ser Gly Phe Arg Leu 
    130                 135                 140                 


Lys Pro Pro Thr Leu Ile His Gly Gln Ala Pro Ser Ala Gly Leu Pro 
145                 150                 155                 160 


Ser Gln Lys Pro Lys Glu Gln Gln Arg Ser Val Leu Arg Pro Ala Val 
                165                 170                 175     


Leu Gln Ala Pro Gln Pro Lys Ala Leu Ser Gln Thr Val Pro Ser Ser 
            180                 185                 190         


Gly Thr Asn Gly Val Ser Leu Pro Ala Asp Cys Thr Gly Ala Val Pro 
        195                 200                 205             


Ala Ala Ser Pro Asp Thr Ala Ala Trp Arg Ser Pro Ser Glu Ala Ala 
    210                 215                 220                 


Asp Glu Val Cys Ala Leu Glu Glu Lys Glu Pro Gln Lys Asn Glu Ser 
225                 230                 235                 240 


Ser Asn Ala Ser Glu Glu Glu Ala Cys Glu Lys Lys Asp Pro Ala Thr 
                245                 250                 255     


Gln Gln Ala Phe Val Phe Gly Gln Asn Leu Arg Asp Arg Val Lys Leu 
            260                 265                 270         


Ile Asn Glu Ser Val Asp Glu Ala Asp Met Glu Asn Ala Gly His Pro 
        275                 280                 285             


Ser Ala Asp Thr Pro Thr Ala Thr Asn Tyr Phe Leu Gln Tyr Ile Ser 
    290                 295                 300                 


Ser Ser Leu Glu Asn Ser Thr Asn Ser Ala Asp Ala Ser Ser Asn Lys 
305                 310                 315                 320 


Phe Val Phe Gly Gln Asn Met Ser Glu Arg Val Leu Ser Pro Pro Lys 
                325                 330                 335     


Leu Asn Glu Val Ser Ser Asp Ala Asn Arg Glu Asn Ala Ala Ala Glu 
            340                 345                 350         


Ser Gly Ser Glu Ser Ser Ser Gln Glu Ala Thr Pro Glu Lys Glu Ser 
        355                 360                 365             


Leu Ala Glu Ser Ala Ala Ala Tyr Thr Lys Ala Thr Ala Arg Lys Cys 
    370                 375                 380                 


Leu Leu Glu Lys Val Glu Val Ile Thr Gly Glu Glu Ala Glu Ser Asn 
385                 390                 395                 400 


Val Leu Gln Met Gln Cys Lys Leu Phe Val Phe Asp Lys Thr Ser Gln 
                405                 410                 415     


Ser Trp Val Glu Arg Gly Arg Gly Leu Leu Arg Leu Asn Asp Met Ala 
            420                 425                 430         


Ser Thr Asp Asp Gly Thr Leu Gln Ser Arg Leu Val Met Arg Thr Gln 
        435                 440                 445             


Gly Ser Leu Arg Leu Ile Leu Asn Thr Lys Leu Trp Ala Gln Met Gln 
    450                 455                 460                 


Ile Asp Lys Ala Ser Glu Lys Ser Ile Arg Ile Thr Ala Met Asp Thr 
465                 470                 475                 480 


Glu Asp Gln Gly Val Lys Val Phe Leu Ile Ser Ala Ser Ser Lys Asp 
                485                 490                 495     


Thr Gly Gln Leu Tyr Ala Ala Leu His His Arg Ile Leu Ala Leu Arg 
            500                 505                 510         


Ser Arg Val Glu Gln Glu Gln Glu Ala Lys Met Pro Ala Pro Glu Pro 
        515                 520                 525             


Gly Ala Ala Pro Ser Asn Glu Glu Asp Asp Ser Asp Asp Asp Asp Val 
    530                 535                 540                 


Leu Ala Pro Ser Gly Ala Thr Ala Ala Gly Ala Gly Asp Glu Gly Asp 
545                 550                 555                 560 


Gly Gln Thr Thr Gly Ser Thr 
                565         

<210>  3479
<211>  796
<212>  DNA
<213>  Homo sapiens

<400>  3479
gcagaaagca ggcgagcctg ggccggcgcg gggccttgtg ggagggctta aggaagtaaa     60

atggcggacc tggcgaacga agatgcagtg caagctgttt gtctttgaca agacctcaca    120

gtcctgggtg gagagaggcc gggggctgct cagactcaat gacatggcgt ccaccgatga    180

cggcacacta cagtcccgac tagtgatgcg gacccagggg agcctgcgac tgatcctcaa    240

caccaagctg tgggcccaga tgcagatcga caaggccagc gagaagagca ttcgcatcac    300

agccatggac accgaggacc agggcgtgaa ggtcttcctg atctcggcca gctccaagga    360

cacaggtcag ttgtatgcag ccctgcacca ccgcatcctg gccctgcgca gccgcgtgga    420

gcaggagcag gaggccaaga tgcccgcgcc tgagcctggg gcagccccat ccaacgagga    480

ggacgacagc gacgatgacg atgtcctggc tccttcaggg gccaccgcag ctggtgctgg    540

tgacgaaggg gacgggcaga cgaccgggag cacatagcgg ccgggagccc ggctgcacac    600

caggctgctg ctttgtccgt ctatccaccc gcccacccgc ccccacccca ccggcagcgt    660

ccaggtgcgg ggccgggaac cacacacccc actgggccgg ccacagtctg gacccgcacg    720

tcctgttcaa aagcagactc gggaactgcc tgaatgtggt ttgggacacg agacctcatc    780

atattgatga gcgaac                                                    796


<210>  3480
<211>  164
<212>  PRT
<213>  Homo sapiens

<400>  3480


Met Gln Cys Lys Leu Phe Val Phe Asp Lys Thr Ser Gln Ser Trp Val 
1               5                   10                  15      


Glu Arg Gly Arg Gly Leu Leu Arg Leu Asn Asp Met Ala Ser Thr Asp 
            20                  25                  30          


Asp Gly Thr Leu Gln Ser Arg Leu Val Met Arg Thr Gln Gly Ser Leu 
        35                  40                  45              


Arg Leu Ile Leu Asn Thr Lys Leu Trp Ala Gln Met Gln Ile Asp Lys 
    50                  55                  60                  


Ala Ser Glu Lys Ser Ile Arg Ile Thr Ala Met Asp Thr Glu Asp Gln 
65                  70                  75                  80  


Gly Val Lys Val Phe Leu Ile Ser Ala Ser Ser Lys Asp Thr Gly Gln 
                85                  90                  95      


Leu Tyr Ala Ala Leu His His Arg Ile Leu Ala Leu Arg Ser Arg Val 
            100                 105                 110         


Glu Gln Glu Gln Glu Ala Lys Met Pro Ala Pro Glu Pro Gly Ala Ala 
        115                 120                 125             


Pro Ser Asn Glu Glu Asp Asp Ser Asp Asp Asp Asp Val Leu Ala Pro 
    130                 135                 140                 


Ser Gly Ala Thr Ala Ala Gly Ala Gly Asp Glu Gly Asp Gly Gln Thr 
145                 150                 155                 160 


Thr Gly Ser Thr 
                

<210>  3481
<211>  3008
<212>  DNA
<213>  Homo sapiens

<400>  3481
cccctcctcc aggcgccttc caggcctgct gatcggacga gacttctgtt gtaatttgga     60

aatgttctcc ctggttctcc aggcccgaag tcactgaggc caagaccata gtcctctcct    120

gcccttgccc cccaggccca gccccagccc aggcaggcct gctgttgata ttttgtcttg    180

tgcttttaga ggaaaggagc agtggcttcc ggttgaagcc accaacgctg atccacggcc    240

aagcccccag cgcaggtagg tcgtctacct ccctggggcg gggggtggct ctctgacgtt    300

tttcagacct ctgctaggcc acaccagggc accgcgggct cagcctgctt tctagaaaga    360

tcacttgtaa cttgacccac gagccctgga aagttccttt aaagagaggc tgtctgagca    420

gggaggttgg gacccctgac tgtgagcgtc gtgtgttcag aaaagtgggc agtggtggca    480

cgggagcagg ctaggcgggg tgcatcgggc gggctccatg cccagcagta gcgcacttgg    540

ttcagcctgt ctgtccttca tgttctggcc cccacatacc acagtgttcg ccccagttag    600

cagggtggct gcattccagc ggcgcgctgc tagtgagccg gctgctagtg aggctgccgg    660

ggatgctgca cagggcaggg cacatgcaag ggtccttgtc ccatctgcct ttggcagagg    720

gacttcctca gcatggctgt tttgaaaaac aggtgcaaaa tgtgcctgta cgtgacccca    780

caccgagtcc tgagcctcca ggtagctgcc tgtgaatgca ctgctctcct cccacagtct    840

ccacttgact gttgagtctg ccggcgcccc gccacgttac tgtgctaact ggattaattc    900

acaggcgtcg gtcactggga gtttcatgta atcacatgta aaaataacag tagccagatc    960

tcctggccag ctgttaaaaa aagacctcaa gtttttaaaa aagtgcttcc ctgcaaagtc   1020

tagcctgcaa ggggcatgaa atgggatgcc aggggtcagt ctctgaagcg cctgggggca   1080

ggcaggggtc cacgggcact gggaaggccg ccttctgttc ctaggtctgc caagccagaa   1140

gcccaaggag cagcagcgga gcgtgcttcg cccggcagtg ttacaagctc cgcagccaaa   1200

ggcgctgtcc cagactgtcc ccagcagtgg caccaacggg gtcagcctcc cagcagactg   1260

cacgggggca gtgcccgcag catcccctga cactgctgca tggagaagtc cttccgaagc   1320

tgccgatgag gtgtgtgcac ttgaggagaa agagccccag aaaaatgagt ccagcaatgc   1380

ctctgaagag gaagcctgtg agaaaaaaga ccccgccaca cagcaagcct ttgtatttgg   1440

gcagaacttg agggacagag ttaagctgat aaatgagagc gtggacgaag ccgacatgga   1500

gaatgctgga caccccagcg cagacacgcc aaccgcaacg aactatttcc tccagtatat   1560

cagttccagg tgtgtgtctc ggtgtcagcg gccagcctgg catggcgatg caggtggccg   1620

cgagggcttc tgccagagag gggtctgtgg tccccgtgcc cgactcaggc ccagaatcca   1680

ggttgctctc aggcccctct ctctcattcc ccactctggg cacaaccttg ggtgggccag   1740

ggtggtgggc cttgtcctgg gattcactgg acgcctgaga caggaccaga gttctgtggg   1800

gttgtccagg ggcccatgga ggctacagcc cagcccttgg agtgtgccct ctgtcttgtg   1860

gacctcatgc ccagagcaga acagagcagg ccagaggcga ctcaggcgcc cccttattct   1920

gggtttgggc acctggggca aagacctcat catgtccttg actgacatgg ctgggggtaa   1980

tgctacccac ggaccagctg cccctccagg tgtctcagaa gaaagcgtgt cccgactggg   2040

agatgggcgg gtagagcagg tggaaggtgg cttccctcat gctgtggggc ccctccatca   2100

gggcgagcta agggttaatg ttttcaatgg cacagggagg tgtgtggctt cctgcctctg   2160

acacgccacc ccgtgcacag tggcggaggc ccctccactg tgccctctgt gtcagtgtgt   2220

gctccatggg tacccataca tttgcctggc cacgttccca cgtgacgccc cacactcatt   2280

gcacatcttc tcttcagttt agagaactca accaatagtg ccgacgcctc cagcaacaaa   2340

tttgtatttg gccagaacat gagcgagcga gttttgagcc ccccaaaatt aaacgaggtc   2400

agttcagatg ccaacaggga aaatgcagct gccgagtcag ggtctgagtc ctcgtcccag   2460

gaggccaccc ctgagaaaga gtccctggct gagtcggcag ccgcctacac caaggcaaca   2520

gcgcggaagt gtttgttgga aaaagtggaa gtcatcaccg gggaggaggc ggagagcaat   2580

gtgttacaga tgcagtgcaa gctgtttgtc tttgacaaga cctcacagtc ctgggtggag   2640

agaggccggg ggctgctcag actcaatgac atggcgtcca ccgatgacgg cacactacag   2700

tcccgactag gtgagctgcc gacggcgggg gctgtggccg ggtccccatg gggagggctg   2760

gggactatgc aattccaaag ggaatgaagc gggggagatc ctgaccctac ccttgtgaga   2820

gtcaaggcac agagtcggtc tcccatgaga gccgcccccc aaaccccctc cctgcaccca   2880

gccctcaaca ccaccctcac acactggctc cagctgccag ctcgtccgtg accctcttag   2940

tgtcaaaatg gacaaaagtc tatggaagtt tttaagctga ttttctgaca aagtggcagg   3000

tttatgat                                                            3008


<210>  3482
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  3482


Met Ser Glu Arg Val Leu Ser Pro Pro Lys Leu Asn Glu Val Ser Ser 
1               5                   10                  15      


Asp Ala Asn Arg Glu Asn Ala Ala Ala Glu Ser Gly Ser Glu Ser Ser 
            20                  25                  30          


Ser Gln Glu Ala Thr Pro Glu Lys Glu Ser Leu Ala Glu Ser Ala Ala 
        35                  40                  45              


Ala Tyr Thr Lys Ala Thr Ala Arg Lys Cys Leu Leu Glu Lys Val Glu 
    50                  55                  60                  


Val Ile Thr Gly Glu Glu Ala Glu Ser Asn Val Leu Gln Met Gln Cys 
65                  70                  75                  80  


Lys Leu Phe Val Phe Asp Lys Thr Ser Gln Ser Trp Val Glu Arg Gly 
                85                  90                  95      


Arg Gly Leu Leu Arg Leu Asn Asp Met Ala Ser Thr Asp Asp Gly Thr 
            100                 105                 110         


Leu Gln Ser Arg Leu Gly Glu Leu Pro Thr Ala Gly Ala Val Ala Gly 
        115                 120                 125             


Ser Pro Trp Gly Gly Leu Gly Thr Met Gln Phe Gln Arg Glu 
    130                 135                 140         

<210>  3483
<211>  977
<212>  DNA
<213>  Homo sapiens

<400>  3483
agaaagcagg cgagcctggg ccggcgcggg gccttgtggg agggcttaag gaagtaaaat     60

ggcggacctg gcgaacgaag aaaagcctgc cattgctccg cccgtctttg tgtttcagaa    120

ggataaagga caaaagtccc ctgcagagca aaaaaacttg tcggattcgg gagaggagcc    180

tcggggggag gctgaggccc cccaccatgg cacgggtcac cccgagtcag ctggcgagca    240

tgccctagaa cctcctgccc ctgctggcgc ctcagccagc actcctccgc ctcccgctcc    300

tgaagcccag cttcctcctt ttccgcgaga actggcaggg aggtcagctg gcggctccag    360

tcctgaaggc ggagaagatt ctgacagaga agatggaaat tactgccctc ctgtcaagcg    420

agaaagaaca tcctctttaa cccagttccc accctcacag tcagaggaaa ggagcagtgg    480

cttccggttg aagccaccaa cgctgatcca cggccaagcc cccagcgcag gtctgccaag    540

ccagaagccc aaggagcagc agcggagcgt gcttcgcccg gcagtgttac aagctccgca    600

gccaaaggcg ctgtcccaga ctgtccccag cagtggcacc aacggggtca gcctcccagc    660

agactgcacg ggggcagtgc ccgcagcatc ccctgacact gctgcatgga gaagtccttc    720

cgaagctgcc gatgaggtgt gtgcacttga ggagaaagag ccccagaaaa atgagtccag    780

caatgcctct gaagaggaag cctgtgagaa aaaagacccc gccacacagc aagcctttgt    840

atttgggcag aacttgaggg acagagttaa gctgataaat gagagcgtgg acgaagccga    900

catggagaat gctggacacc ccagcgcaga cacgccaacc gcaacgaact atttcctcca    960

gtatatcagt tccaggt                                                   977


<210>  3484
<211>  305
<212>  PRT
<213>  Homo sapiens

<400>  3484


Met Ala Asp Leu Ala Asn Glu Glu Lys Pro Ala Ile Ala Pro Pro Val 
1               5                   10                  15      


Phe Val Phe Gln Lys Asp Lys Gly Gln Lys Ser Pro Ala Glu Gln Lys 
            20                  25                  30          


Asn Leu Ser Asp Ser Gly Glu Glu Pro Arg Gly Glu Ala Glu Ala Pro 
        35                  40                  45              


His His Gly Thr Gly His Pro Glu Ser Ala Gly Glu His Ala Leu Glu 
    50                  55                  60                  


Pro Pro Ala Pro Ala Gly Ala Ser Ala Ser Thr Pro Pro Pro Pro Ala 
65                  70                  75                  80  


Pro Glu Ala Gln Leu Pro Pro Phe Pro Arg Glu Leu Ala Gly Arg Ser 
                85                  90                  95      


Ala Gly Gly Ser Ser Pro Glu Gly Gly Glu Asp Ser Asp Arg Glu Asp 
            100                 105                 110         


Gly Asn Tyr Cys Pro Pro Val Lys Arg Glu Arg Thr Ser Ser Leu Thr 
        115                 120                 125             


Gln Phe Pro Pro Ser Gln Ser Glu Glu Arg Ser Ser Gly Phe Arg Leu 
    130                 135                 140                 


Lys Pro Pro Thr Leu Ile His Gly Gln Ala Pro Ser Ala Gly Leu Pro 
145                 150                 155                 160 


Ser Gln Lys Pro Lys Glu Gln Gln Arg Ser Val Leu Arg Pro Ala Val 
                165                 170                 175     


Leu Gln Ala Pro Gln Pro Lys Ala Leu Ser Gln Thr Val Pro Ser Ser 
            180                 185                 190         


Gly Thr Asn Gly Val Ser Leu Pro Ala Asp Cys Thr Gly Ala Val Pro 
        195                 200                 205             


Ala Ala Ser Pro Asp Thr Ala Ala Trp Arg Ser Pro Ser Glu Ala Ala 
    210                 215                 220                 


Asp Glu Val Cys Ala Leu Glu Glu Lys Glu Pro Gln Lys Asn Glu Ser 
225                 230                 235                 240 


Ser Asn Ala Ser Glu Glu Glu Ala Cys Glu Lys Lys Asp Pro Ala Thr 
                245                 250                 255     


Gln Gln Ala Phe Val Phe Gly Gln Asn Leu Arg Asp Arg Val Lys Leu 
            260                 265                 270         


Ile Asn Glu Ser Val Asp Glu Ala Asp Met Glu Asn Ala Gly His Pro 
        275                 280                 285             


Ser Ala Asp Thr Pro Thr Ala Thr Asn Tyr Phe Leu Gln Tyr Ile Ser 
    290                 295                 300                 


Ser 
305 

<210>  3485
<211>  942
<212>  DNA
<213>  Homo sapiens

<400>  3485
agatggctcg tgcgcaggtg cgtgctagga gcgcggctcg tcagggcagg ctgctctgca     60

gggcaggcga tccggggctc gcctccgcgc ggcattcagc gcgcaggcgc gagctggccg    120

cctcacacgg agtcggcttg ttaagtgcgc acgcgcggga gtttctggca gaaagcaggc    180

gagcctgggc cggcgcgggg ccttgtggga gggcttaagg aagtaaaatg gcggacctgg    240

cgaacgaaga aaagcctgcc attgctccgc ccgtctttgt gtttcagaag gataaaggac    300

aaaagaggtc agctggcggc tccagtcctg aaggcggaga agattctgac agagaagatg    360

gaaattactg ccctcctgtc aagcgagaaa gaacatcctc tttaacccag ttcccaccct    420

cacagtcaga ggaaaggagc agtggcttcc ggttgaagcc accaacgctg atccacggcc    480

aagcccccag cgcaggtctg ccaagccaga agcccaagga gcagcagcgg agcgtgcttc    540

gcccggcagt gttacaagct ccgcagccaa aggcgctgtc ccagactgtc cccagcagtg    600

gcaccaacgg ggtcagcctc ccagcagact gcacgggggc agtgcccgca gcatcccctg    660

acactgctgc atggagaagt ccttccgaag ctgccgatga ggtgtgtgca cttgaggaga    720

aagagcccca gaaaaatgag tccagcaatg cctctgaaga ggaagcctgt gagaaaaaag    780

accccgccac acagcaagcc tttgtatttg ggcagaactt gagggacaga gttaagctga    840

taaatgagag cgtggacgaa gccgacatgg agaatgctgg acaccccagc gcagacacgc    900

caaccgcaac gaactatttc ctccagtata tcagttccag gt                       942


<210>  3486
<211>  237
<212>  PRT
<213>  Homo sapiens

<400>  3486


Met Ala Asp Leu Ala Asn Glu Glu Lys Pro Ala Ile Ala Pro Pro Val 
1               5                   10                  15      


Phe Val Phe Gln Lys Asp Lys Gly Gln Lys Arg Ser Ala Gly Gly Ser 
            20                  25                  30          


Ser Pro Glu Gly Gly Glu Asp Ser Asp Arg Glu Asp Gly Asn Tyr Cys 
        35                  40                  45              


Pro Pro Val Lys Arg Glu Arg Thr Ser Ser Leu Thr Gln Phe Pro Pro 
    50                  55                  60                  


Ser Gln Ser Glu Glu Arg Ser Ser Gly Phe Arg Leu Lys Pro Pro Thr 
65                  70                  75                  80  


Leu Ile His Gly Gln Ala Pro Ser Ala Gly Leu Pro Ser Gln Lys Pro 
                85                  90                  95      


Lys Glu Gln Gln Arg Ser Val Leu Arg Pro Ala Val Leu Gln Ala Pro 
            100                 105                 110         


Gln Pro Lys Ala Leu Ser Gln Thr Val Pro Ser Ser Gly Thr Asn Gly 
        115                 120                 125             


Val Ser Leu Pro Ala Asp Cys Thr Gly Ala Val Pro Ala Ala Ser Pro 
    130                 135                 140                 


Asp Thr Ala Ala Trp Arg Ser Pro Ser Glu Ala Ala Asp Glu Val Cys 
145                 150                 155                 160 


Ala Leu Glu Glu Lys Glu Pro Gln Lys Asn Glu Ser Ser Asn Ala Ser 
                165                 170                 175     


Glu Glu Glu Ala Cys Glu Lys Lys Asp Pro Ala Thr Gln Gln Ala Phe 
            180                 185                 190         


Val Phe Gly Gln Asn Leu Arg Asp Arg Val Lys Leu Ile Asn Glu Ser 
        195                 200                 205             


Val Asp Glu Ala Asp Met Glu Asn Ala Gly His Pro Ser Ala Asp Thr 
    210                 215                 220                 


Pro Thr Ala Thr Asn Tyr Phe Leu Gln Tyr Ile Ser Ser 
225                 230                 235         

<210>  3487
<211>  546
<212>  DNA
<213>  Homo sapiens

<400>  3487
cccccatatt ttctattgta aattatttca ttccttggcc aatgatgagc aaccaggtta     60

tttcctgtcc tctgccggca ctaaggcttc tgcagggcac aggtgtttct tgttgtttgg    120

agacaggttt ttgctctgtc acccaggctg gagtgcagtg gtgtgatctc agctcactac    180

aactcccagg ctcaagcagt cctcctgtct cagccttctg agtagctggg agtgcaggca    240

catgcagagg agacgtgtgg agtacatgat ctggtgtggg attgctgggc atccgtctgg    300

gccaagtgtg gcactggttt tgattactct gttttgtttt ggtttttgat aggagaaaga    360

gccccagaaa aatgagtcca gcaatgcctc tgaagaggaa gcctgtgaga aaaaagaccc    420

cgccacacag caagcctttg tatttgggca gaacttgagg gacagagtta agctgataaa    480

tgagagcgtg gacgaagccg acatggagaa tgctggacac cccagcgcag acacgccaac    540

cgcaac                                                               546


<210>  3488
<211>  59
<212>  PRT
<213>  Homo sapiens

<400>  3488


Met Met Ser Asn Gln Val Ile Ser Cys Pro Leu Pro Ala Leu Arg Leu 
1               5                   10                  15      


Leu Gln Gly Thr Gly Val Ser Cys Cys Leu Glu Thr Gly Phe Cys Ser 
            20                  25                  30          


Val Thr Gln Ala Gly Val Gln Trp Cys Asp Leu Ser Ser Leu Gln Leu 
        35                  40                  45              


Pro Gly Ser Ser Ser Pro Pro Val Ser Ala Phe 
    50                  55                  

<210>  3489
<211>  636
<212>  DNA
<213>  Homo sapiens

<400>  3489
agaaagcagg cgagcctggg ccggcgcggg gccttgtggg agggcttaag gaagtaaaat     60

ggcggacctg gcgaacgaag aaaagcctgc cattgctccg cccgtctttg tgtttcagaa    120

ggataaagga caaaagtccc ctgcagagca aaaaaacttg tcggattcgg gagaggagcc    180

tcggggggag gctgaggccc cccaccatgg cacgggtcac cccgagtcag ctggcgagca    240

tgccctagaa cctcctgccc ctgctggcgc ctcagccagc actcctccgc ctcccgctcc    300

tgaagcccag cttcctcctt ttccgcgaga actggcaggg gaagaagaaa agactcttcc    360

tttgaaccca gaaggaatcc cctgagccct ttatctttgt attaagaagc cttttgaaga    420

ttataggtgg agaagattgt gaactctcaa gaacaagaaa tgtcttgggt ttttgaagtt    480

tgataaattg ggaaaggtaa acattatcct acattcagga ttgaaaactc catcctgtag    540

gtaactcatg acagaagacc cctattctca ggacagggaa aaaggactct taacaagaaa    600

agaagggacc cagctctacc gcctgagcac caggca                              636


<210>  3490
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  3490


Met Ala Asp Leu Ala Asn Glu Glu Lys Pro Ala Ile Ala Pro Pro Val 
1               5                   10                  15      


Phe Val Phe Gln Lys Asp Lys Gly Gln Lys Ser Pro Ala Glu Gln Lys 
            20                  25                  30          


Asn Leu Ser Asp Ser Gly Glu Glu Pro Arg Gly Glu Ala Glu Ala Pro 
        35                  40                  45              


His His Gly Thr Gly His Pro Glu Ser Ala Gly Glu His Ala Leu Glu 
    50                  55                  60                  


Pro Pro Ala Pro Ala Gly Ala Ser Ala Ser Thr Pro Pro Pro Pro Ala 
65                  70                  75                  80  


Pro Glu Ala Gln Leu Pro Pro Phe Pro Arg Glu Leu Ala Gly Glu Glu 
                85                  90                  95      


Glu Lys Thr Leu Pro Leu Asn Pro Glu Gly Ile Pro 
            100                 105             

<210>  3491
<211>  639
<212>  DNA
<213>  Homo sapiens

<400>  3491
cgcgcggccc gaggcgggtc ttgaagcact cgttttccca ctcgttttcc ggggttcccc     60

cgcggtggga cagtgagcag ttcagggcgc cgcagccgag gccttcctcc aggaaaggtt    120

tgctggctcc tgccttagaa gatgagaaag tttgtgatgg atggagaaga ggatcttcca    180

gaaaataacc agggctttcc agccactgga tccaaagact atgctctccc tgagggtgga    240

gacggagcca ggtttgccca tgtgagcatc tgcaggatcc tggagatgtc tcaagcctgg    300

cagcagagaa agactgtcca aggaggcagc aggagccaag gccagtgaca ccacatctca    360

aggagccaaa tgacgatgcg gattttcagg ctaaaactgt gaggccagat tttgcgggcg    420

gtgagctgga aggagcactg gactaggagt cctgagaggt tagagtataa gactccatcc    480

accaggagga catactggct cacacataaa aagaaagttt tggaacagat gatccttctg    540

ctgtttaccc ccgaaccccc aggctattta agagtagaat cctttgcttg ggtaattacg    600

ttgacattga cactaaaagg atgcatagtt gtcttgaca                           639


<210>  3492
<211>  68
<212>  PRT
<213>  Homo sapiens

<400>  3492


Met Arg Lys Phe Val Met Asp Gly Glu Glu Asp Leu Pro Glu Asn Asn 
1               5                   10                  15      


Gln Gly Phe Pro Ala Thr Gly Ser Lys Asp Tyr Ala Leu Pro Glu Gly 
            20                  25                  30          


Gly Asp Gly Ala Arg Phe Ala His Val Ser Ile Cys Arg Ile Leu Glu 
        35                  40                  45              


Met Ser Gln Ala Trp Gln Gln Arg Lys Thr Val Gln Gly Gly Ser Arg 
    50                  55                  60                  


Ser Gln Gly Gln 
65              

<210>  3493
<211>  2245
<212>  DNA
<213>  Homo sapiens

<400>  3493
gcccgtcagc ccccgcgtag gcctgcacgt cttaggatca ctcagcctct gggttcccca     60

gggaacgtag agcagggggt gtgttgctgc catgaagtct ggcctggggc ccgggttcca    120

tgctcccctg agggtcccca gcctctgtcc gcttgtcccc agctccatgg tgatccggga    180

cctgaccctg cgcagcgctg ccagcttcgg ctccttccac ctcatccgcc tgctctacga    240

cgagtacatg ttctacctgg tggagcaccg cgtcgcggag gccaccggag agacgccgat    300

cgctgtgatg ggagagttca acgatctcgc ctctctgtcg ctgacgctgc tcgacaaaga    360

tgacatgggc gatgagcagc gtggcagcga ggcgggccca gacgcccgca gcctgggtga    420

gcccctggta aagcgggagc gcagtgaccc caaccactcc ctgcagggca tctagcagcc    480

ccggccggcg cctcctcgag gttccaaaag atgccgcctg gtcactctgg gaacctggat    540

ttcaccggct ccaccaaatt agtgcctctt agatgatgtg atgtttactt tgactcaagc    600

gggggctccc ggggtcagtg ttcaagaagg aaagcagttg ttgaagctac agaagcccag    660

gccagggctc ccactggctg tagctgtgct ctgggtcccc aggtccctgc gcagccacca    720

gggccccacc agaccatggg ttccttattc tggacaaacc ctcctctgct ggaaccctgg    780

actttggccc cagtcccttt aagagctgaa agggctgtgc tgagagcact ggcctctgca    840

ctcaactgga accaattttc accatgattt taaaaattaa aaaaacctgg cagagcccga    900

ctagaaaggg acggcctctc ccctcctacc tgccaccgct ggggaggcac agagctcgcc    960

agcgtccctg gagtcccctc aggaatggaa agtggagtgc ccttgtctgg tagcaccatg   1020

tgggagggac ccagctgggc gcagcgccct gtggcctttt agatccagac ctccctgccg   1080

gatgccccga ggcgggaggc cggctgtgct gcaggaaccc atctccagat gccaaaggac   1140

ttgaggggca gctgacaatc gctgtgtccc ggcagatccg cagctcgaaa aagaacaagc   1200

cacagaaacg ggctcgctcg tgccaggaca cagcagtgtc tttcaaaaaa tcaaaaccag   1260

aagttttatc agcagcagga aggatgtggg actctgtcca agttcaccgt caccatcaag   1320

ccactggctg tggaaggagt ttgtccaaca gggtcagtgt cacagccaca acttcagaaa   1380

gcagccatcc cgcgtgtcgt ccaaacagca gtgcctgcgt cccgctccac ggagtcttcc   1440

agaacacctc cctctgaact aatcccggag caccccaccc ccagcgagtc ccacctggac   1500

ctcttcaaag tcaaaactct tctctcggga caaacaaata ttcgggactt tcgaagccct   1560

gaacttgaga caccaagttt gtctccatgg aaacacgtag ccgctgcagt tggacagctg   1620

cgtgctggag ttctgtcccc aaaccaactg cagagaagaa agacgagcct cggcccagga   1680

cgcgatttct aacgaaatgc aatagttttc tctttttgga aaaatgttta taccaatagt   1740

tttgtgcgct aattgttatt agaacgtttc ttatgaatgt gtacattgca gtatattcag   1800

tcccaaatgt tttgttctca ttcacacaga aggtactaat gtcagctcac gtggccttta   1860

aaaacctact tccccgcccg caggagctca gagcatcgct gggcctgcgc cagagtgagg   1920

ggtgcaggaa gacaaagacg cgtgctcact ttagaaacga aaagctggga ataatcacac   1980

tgtttgtctg gtcgtatagc ccaaacctta gttgaaatca gacagaaaga atgtctttaa   2040

aatatacatc tcctctcctt ggagacactg aagctcacag ttaacggatt gtaatgcccg   2100

gcttttcctc actcctggta accaatacaa gctggtttct gccttaggct ctggcctgtc   2160

tttccgatcc acgaggagga acagaggtgg cagcgaagcc acaagcctct caggcctggt   2220

ctcatttttc atagcagtaa acaca                                         2245


<210>  3494
<211>  127
<212>  PRT
<213>  Homo sapiens

<400>  3494


Met Lys Ser Gly Leu Gly Pro Gly Phe His Ala Pro Leu Arg Val Pro 
1               5                   10                  15      


Ser Leu Cys Pro Leu Val Pro Ser Ser Met Val Ile Arg Asp Leu Thr 
            20                  25                  30          


Leu Arg Ser Ala Ala Ser Phe Gly Ser Phe His Leu Ile Arg Leu Leu 
        35                  40                  45              


Tyr Asp Glu Tyr Met Phe Tyr Leu Val Glu His Arg Val Ala Glu Ala 
    50                  55                  60                  


Thr Gly Glu Thr Pro Ile Ala Val Met Gly Glu Phe Asn Asp Leu Ala 
65                  70                  75                  80  


Ser Leu Ser Leu Thr Leu Leu Asp Lys Asp Asp Met Gly Asp Glu Gln 
                85                  90                  95      


Arg Gly Ser Glu Ala Gly Pro Asp Ala Arg Ser Leu Gly Glu Pro Leu 
            100                 105                 110         


Val Lys Arg Glu Arg Ser Asp Pro Asn His Ser Leu Gln Gly Ile 
        115                 120                 125         

<210>  3495
<211>  4761
<212>  DNA
<213>  Homo sapiens

<400>  3495
aattagctgg gtgtggtggc acatgcctat aatcccagct actcaggagg ctgaggcatg     60

agaatcactt gagcctagga ggcagaggtg gccctgagcc gagatcacat cactgcactc    120

cagcctggga aacagagtaa gactctggct caagaaaaag ataagtaaat aaagctcttt    180

ttcaggggtg ggtggtgaaa tctcaaaatt ttgtaatagt gtatttttta atagaccaaa    240

tgattgagac ccactatgtt ggagagacag tgttttcttc tccttcccag tctgctgggc    300

actggacaag gccccctgag attagggcag acttccagag gtcatgcact ctgctctccc    360

ggcacccata ggtgagcgat gtcccacagg gaaggtgcca cagggcagta ctcacgtggc    420

tgcccaagct gcagatcaga atggccccaa gacatggggg tggcatgtgt gttttttcta    480

tcatagaggt ggcgattgcc ttctcatcgc ctgcaccctg aggctgatgg gtgggagagg    540

tctcaccatc ctactttccc ctggtcctcc agtgtacctt ctgcacttct taaaggtgac    600

cctgacgtcc tccttggctt gaagcaaggg tagctaatga gagaaggcag aaccaccgtg    660

gtcggaggcc gtgggagaag cagttaccct ctcattcttg aactcagctc cgctcgcctg    720

ctctctgaaa tacacactca acctgctctt tgcagaagtg tcaagtcttt ggcctcctta    780

agaaaggaag catatacttc aagttcatct cctcccgctt cagtcctctg gtcgtcaggg    840

tgggctgcag cagattttac gtcgctgttt tccgtgtgcg agtctaggac aaaccaaatg    900

cgtgcgaatg ccttagtggc cacgcacagc tgtgtgcctc ctccatcgcg tggacctgcc    960

gcccacctcc ctccccacct ccatcaggtc cttcaggatc caactcaaaa gccccttcct   1020

ccaggaagtt ctgctgttag ctgcccaact ctttcttcca aaactctttt ctcttttcca   1080

aaaatcttct tcgcacagct cccactgggt aaacattcgc cagacagtgt ccagtggccc   1140

tggatcctac ggcctcctgg tggcagggtc tgagtctttg gcctcgctgc tattttccca   1200

aagcctccag cagcggggag accctgggat ttgcgacagg acagcctggc tggggagtca   1260

aggctgccat ctctccttgc tttcattctg gttccccatc gatgtggcgt ggggaaagga   1320

gcaggtgact atgatgctgg cttggctgac actggaatgg atgcagtggc tgcatattaa   1380

tgctacggcg tgcacacaca tatgccaggt taaagttcag tagcaagttt ttacaacatg   1440

atttctgctg cttctgttgg acgggctctc gggcttacct acgtgtgcga agcaacactc   1500

cctaccgcag ctttcatgca caatttaact cacccccgcc ctgcctgcgt ggagcctcat   1560

ttttattttg taggagctcg aatcattatt tggatattaa taaaaacaaa tcttggctga   1620

tgctaaccat ctgatttcct tttttttttt ttccattttg ttttgttttg tttctgcaca   1680

cattttcttt agcttgaaat ggcgattgaa aacctccaaa aaagcgaagg aatcacatca   1740

cacaaaagcg gtttactcaa cagccatctc cagtggctgt tggataatta tgaaacagcg   1800

gaaggtgtga gtctccccag aagttctctt tacaaccact accttcggca ctgccaggag   1860

cacaagctag acccagtgaa cgccgcctcc ttcgggaaac tgatccgttc tgtgtttatg   1920

gggctgagaa cgcggcggct gggcaccagg tgggcaactg tagatgtggt gatgaacctc   1980

cagttccact acatcgagaa gctgtggctc tccttctgga actctaaggc ctcctccagc   2040

gacggcccca cctctcttcc tgccagtgac gaagaccccg agggcgccgt cctgcccaag   2100

gacaagctta tctccctgtg tcagtgcgac cccatcctca ggtggatgag gagctgcgac   2160

cacatcctct accaggcgct ggtggagatt ctcatccccg acgtgctgag gccggtcccc   2220

agtaccttga cacaggccat ccgtaacttt gccaagagct tggaaggctg gttgacaaat   2280

gccatgagtg acttcccaca acaggtcatc cagaccaagg tgggcgtcgt cagtgccttc   2340

gcccagacgc tgcggcgcta cacgtccctc aaccacctgg cgcaggcggc ccgggcggtg   2400

ctgcagaaca cgtcccagat caaccagatg ctcagcgacc tcaaccgcgt ggactttgcc   2460

aacgtgcagg agcaggcctc gtgggtgtgc cagtgcgagg agagtgtggt gcagcggctg   2520

gagcaggatt tcaagctgac cctgcagcag cagagctccc tggaccagtg ggccagctgg   2580

ctggacagtg tggtcaccca ggtcctgaag cagcatgccg gcagccccag cttccccaag   2640

gccgcccggc agttcttgct gaaatggtcc ttttacagct ccatggtgat ccgggacctg   2700

accctgcgca gcgctgccag cttcggctcc ttccacctca tccgcctgct ctacgacgag   2760

tacatgttct acctggtgga gcaccgcgtc gcggaggcca ccggagagac gccgatcgct   2820

gtgatgggag agttcaacga tctcgcctct ctgtcgctga cgctgctcga caaagatgac   2880

atgggcgatg agcagcgtgg cagcgaggcg ggcccagacg cccgcagcct gggtgagccc   2940

ctggtaaagc gggagcgcag tgaccccaac cactccctgc agggcatcta gcagccccgg   3000

ccggcgcctc ctcgaggttc caaaagatgc cgcctggtca ctctgggaac ctggatttca   3060

ccggctccac caaattagtg cctcttagat gatgtgatgt ttactttgac tcaagcgggg   3120

gctcccgggg tcagtgttca agaaggaaag cagttgttga agctacagaa gcccaggcca   3180

gggctcccac tggctgtagc tgtgctctgg gtccccaggt ccctgcgcag ccaccagggc   3240

cccaccagac catgggttcc ttattctgga caaaccctcc tctgctggaa ccctggactt   3300

tggccccagt ccctttaaga gctgaaaggg ctgtgctgag agcactggcc tctgcactca   3360

actggaacca attttcacca tgattttaaa aattaaaaaa acctggcaga gcccgactag   3420

aaagggacgg cctctcccct cctacctgcc accgctgggg aggcacagag ctcgccagcg   3480

tccctggagt cccctcagga atggaaagtg gagtgccctt gtctggtagc accatgtggg   3540

agggacccag ctgggcgcag cgccctgtgg ccttttagat ccagacctcc ctgccggatg   3600

ccccgaggcg ggaggccggc tgtgctgcag gaacccatct ccagatgcca aaggacttga   3660

ggggcagctg acaatcgctg tgtcccggca gatccgcagc tcgaaaaaga acaagccaca   3720

gaaacgggct cgctcgtgcc aggacacagc agtgtctttc aaaaaatcaa aaccagaagt   3780

tttatcagca gcaggaagga tgtgggactc tgtccaagtt caccgtcacc atcaagccac   3840

tggctgtgga aggagtttgt ccaacagggt cagtgtcaca gccacaactt cagaaagcag   3900

ccatcccgcg tgtcgtccaa acagcagtgc ctgcgtcccg ctccacggag tcttccagaa   3960

cacctccctc tgaactaatc ccggagcacc ccacccccag cgagtcccac ctggacctct   4020

tcaaagtcaa aactcttctc tcgggacaaa caaatattcg ggactttcga agccctgaac   4080

ttgagacacc aagtttgtct ccatggaaac acgtagccgc tgcagttgga cagctgcgtg   4140

ctggagttct gtccccaaac caactgcaga gaagaaagac gagcctcggc ccaggacgcg   4200

atttctaacg aaatgcaata gttttctctt tttggaaaaa tgtttatacc aatagttttg   4260

tgcgctaatt gttattagaa cgtttcttat gaatgtgtac attgcagtat attcagtccc   4320

aaatgttttg ttctcattca cacagaaggt actaatgtca gctcacgtgg cctttaaaaa   4380

cctacttccc cgcccgcagg agctcagagc atcgctgggc ctgcgccaga gtgaggggtg   4440

caggaagaca aagacgcgtg ctcactttag aaacgaaaag ctgggaataa tcacactgtt   4500

tgtctggtcg tatagcccaa accttagttg aaatcagaca gaaagaatgt ctttaaaata   4560

tacatctcct ctccttggag acactgaagc tcacagttaa cggattgtaa tgcccggctt   4620

ttcctcactc ctggtaacca atacaagctg gtttctgcct taggctctgg cctgtctttc   4680

cgatccacga ggaggaacag aggtggcagc gaagccacaa gcctctcagg cctggtctca   4740

tttttcatag cagtaaacac a                                             4761


<210>  3496
<211>  430
<212>  PRT
<213>  Homo sapiens

<400>  3496


Met Ala Ile Glu Asn Leu Gln Lys Ser Glu Gly Ile Thr Ser His Lys 
1               5                   10                  15      


Ser Gly Leu Leu Asn Ser His Leu Gln Trp Leu Leu Asp Asn Tyr Glu 
            20                  25                  30          


Thr Ala Glu Gly Val Ser Leu Pro Arg Ser Ser Leu Tyr Asn His Tyr 
        35                  40                  45              


Leu Arg His Cys Gln Glu His Lys Leu Asp Pro Val Asn Ala Ala Ser 
    50                  55                  60                  


Phe Gly Lys Leu Ile Arg Ser Val Phe Met Gly Leu Arg Thr Arg Arg 
65                  70                  75                  80  


Leu Gly Thr Arg Trp Ala Thr Val Asp Val Val Met Asn Leu Gln Phe 
                85                  90                  95      


His Tyr Ile Glu Lys Leu Trp Leu Ser Phe Trp Asn Ser Lys Ala Ser 
            100                 105                 110         


Ser Ser Asp Gly Pro Thr Ser Leu Pro Ala Ser Asp Glu Asp Pro Glu 
        115                 120                 125             


Gly Ala Val Leu Pro Lys Asp Lys Leu Ile Ser Leu Cys Gln Cys Asp 
    130                 135                 140                 


Pro Ile Leu Arg Trp Met Arg Ser Cys Asp His Ile Leu Tyr Gln Ala 
145                 150                 155                 160 


Leu Val Glu Ile Leu Ile Pro Asp Val Leu Arg Pro Val Pro Ser Thr 
                165                 170                 175     


Leu Thr Gln Ala Ile Arg Asn Phe Ala Lys Ser Leu Glu Gly Trp Leu 
            180                 185                 190         


Thr Asn Ala Met Ser Asp Phe Pro Gln Gln Val Ile Gln Thr Lys Val 
        195                 200                 205             


Gly Val Val Ser Ala Phe Ala Gln Thr Leu Arg Arg Tyr Thr Ser Leu 
    210                 215                 220                 


Asn His Leu Ala Gln Ala Ala Arg Ala Val Leu Gln Asn Thr Ser Gln 
225                 230                 235                 240 


Ile Asn Gln Met Leu Ser Asp Leu Asn Arg Val Asp Phe Ala Asn Val 
                245                 250                 255     


Gln Glu Gln Ala Ser Trp Val Cys Gln Cys Glu Glu Ser Val Val Gln 
            260                 265                 270         


Arg Leu Glu Gln Asp Phe Lys Leu Thr Leu Gln Gln Gln Ser Ser Leu 
        275                 280                 285             


Asp Gln Trp Ala Ser Trp Leu Asp Ser Val Val Thr Gln Val Leu Lys 
    290                 295                 300                 


Gln His Ala Gly Ser Pro Ser Phe Pro Lys Ala Ala Arg Gln Phe Leu 
305                 310                 315                 320 


Leu Lys Trp Ser Phe Tyr Ser Ser Met Val Ile Arg Asp Leu Thr Leu 
                325                 330                 335     


Arg Ser Ala Ala Ser Phe Gly Ser Phe His Leu Ile Arg Leu Leu Tyr 
            340                 345                 350         


Asp Glu Tyr Met Phe Tyr Leu Val Glu His Arg Val Ala Glu Ala Thr 
        355                 360                 365             


Gly Glu Thr Pro Ile Ala Val Met Gly Glu Phe Asn Asp Leu Ala Ser 
    370                 375                 380                 


Leu Ser Leu Thr Leu Leu Asp Lys Asp Asp Met Gly Asp Glu Gln Arg 
385                 390                 395                 400 


Gly Ser Glu Ala Gly Pro Asp Ala Arg Ser Leu Gly Glu Pro Leu Val 
                405                 410                 415     


Lys Arg Glu Arg Ser Asp Pro Asn His Ser Leu Gln Gly Ile 
            420                 425                 430 

<210>  3497
<211>  4188
<212>  DNA
<213>  Homo sapiens

<400>  3497
aaggtggggc gcggagcctg gtaaccgttg ccggtaacaa cgccccgccc cgtcgggcgg     60

gcgggctgcg cgaggctggc tggcggcggg agccggagga ggagcggccg ccgccgccac    120

cgccgccgcc atagagactg tagccgtgga gactgttact taccaacggg gaccaacacg    180

cagcagccgc tgccgccgcc gcgggagccg ctgcccgaac tcccggcccg aactccagac    240

ctgagcatgc agaattccga gggtggagcg gattcgccag cgtccgtggc tctgcgtccc    300

tcggcggcag ccccgcctgt gccagcctcc ccgcagaggg tgttggtcca ggcagccagc    360

tccaatccca aaggggccca gatgcagccg atctccctcc ccagagttca gcaggtaccc    420

cagcaggtgc agccggtgca gcacgtgtat cctgcccagg tgcagtacgt ggaaggggga    480

gacgccgtct acaccaatgg agccatacga acagcctaca cctacaaccc cgagcctcag    540

atgtacgccc ccagcagcac ggcttcttac ttcgaggccc caggcggtgc ccaggtgacc    600

gtggcagcct cgtccccgcc agcggtcccc tcccacagca tggtgggcat caccatggat    660

gtcgggggga gccccatcgt ctccagcgcg ggagcctatc tcatccacgg ggggatggac    720

agcaccagac actccctggc ccacacctcc cgctcatcgc ccgccacgct tgaaatggcg    780

attgaaaacc tccaaaaaag cgaaggaatc acatcacaca aaagcggttt actcaacagc    840

catctccagt ggctgttgga taattatgaa acagcggaag gtgtgagtct ccccagaagt    900

tctctttaca accactacct tcggcactgc caggagcaca agctagaccc agtgaacgcc    960

gcctccttcg ggaaactgat ccgttctgtg tttatggggc tgagaacgcg gcggctgggc   1020

accaggggca actcgaagta ccattactat gggattcgtc tgaagccgga ctcaccactg   1080

aaccggctgc aggaggacac gcagtacatg gccatgcggc agcagcccat gcaccagaag   1140

cccaggtacc ggccagccca gaagacggac agcctcgggg acagcggctc ccacagcggc   1200

ctgcacagca ctccggaaca gaccatggcc gtgcagagcc agcaccacca gcagtacata   1260

gatgtctccc acgtcttccc cgagttccca gcgcccgacc tgggcagctt cctgctgcag   1320

gacggcgtca cactgcacga cgtcaaggcc ctgcagctgg tgtacagacg gcactgcgag   1380

gcaactgtag atgtggtgat gaacctccag ttccactaca tcgagaagct gtggctctcc   1440

ttctggaact ctaaggcctc ctccagcgac ggccccacct ctcttcctgc cagtgacgaa   1500

gaccccgagg gcgccgtcct gcccaaggac aagcttatct ccctgtgtca gtgcgacccc   1560

atcctcaggt ggatgaggag ctgcgaccac atcctctacc aggcgctggt ggagattctc   1620

atccccgacg tgctgaggcc ggtccccagt accttgacac aggccatccg taactttgcc   1680

aagagcttgg aaggctggtt gacaaatgcc atgagtgact tcccacaaca ggtcatccag   1740

accaaggtgg gcgtcgtcag tgccttcgcc cagacgctgc ggcgctacac gtccctcaac   1800

cacctggcgc aggcggcccg ggcggtgctg cagaacacgt cccagatcaa ccagatgctc   1860

agcgacctca accgcgtgga ctttgccaac gtgcaggagc aggcctcgtg ggtgtgccag   1920

tgcgaggaga gtgtggtgca gcggctggag caggatttca agctgaccct gcagcagcag   1980

agctccctgg accagtgggc cagctggctg gacagtgtgg tcacccaggt cctgaagcag   2040

catgccggca gccccagctt ccccaaggcc gcccggcagt tcttgctgaa atggtccttt   2100

tacagctcca tggtgatccg ggacctgacc ctgcgcagcg ctgccagctt cggctccttc   2160

cacctcatcc gcctgctcta cgacgagtac atgttctacc tggtggagca ccgcgtcgcg   2220

gaggccaccg gagagacgcc gatcgctgtg atgggagagt tcaacgatct cgcctctctg   2280

tcgctgacgc tgctcgacaa agatgacatg ggcgatgagc agcgtggcag cgaggcgggc   2340

ccagacgccc gcagcctggg tgagcccctg gtaaagcggg agcgcagtga ccccaaccac   2400

tccctgcagg gcatctagca gccccggccg gcgcctcctc gaggttccaa aagatgccgc   2460

ctggtcactc tgggaacctg gatttcaccg gctccaccaa attagtgcct cttagatgat   2520

gtgatgttta ctttgactca agcgggggct cccggggtca gtgttcaaga aggaaagcag   2580

ttgttgaagc tacagaagcc caggccaggg ctcccactgg ctgtagctgt gctctgggtc   2640

cccaggtccc tgcgcagcca ccagggcccc accagaccat gggttcctta ttctggacaa   2700

accctcctct gctggaaccc tggactttgg ccccagtccc tttaagagct gaaagggctg   2760

tgctgagagc actggcctct gcactcaact ggaaccaatt ttcaccatga ttttaaaaat   2820

taaaaaaacc tggcagagcc cgactagaaa gggacggcct ctcccctcct acctgccacc   2880

gctggggagg cacagagctc gccagcgtcc ctggagtccc ctcaggaatg gaaagtggag   2940

tgcccttgtc tggtagcacc atgtgggagg gacccagctg ggcgcagcgc cctgtggcct   3000

tttagatcca gacctccctg ccggatgccc cgaggcggga ggccggctgt gctgcaggaa   3060

cccatctcca gatgccaaag gacttgaggg gcagctgaca atcgctgtgt cccggcagat   3120

ccgcagctcg aaaaagaaca agccacagaa acgggctcgc tcgtgccagg acacagcagt   3180

gtctttcaaa aaatcaaaac cagaagtttt atcagcagca ggaaggatgt gggactctgt   3240

ccaagttcac cgtcaccatc aagccactgg ctgtggaagg agtttgtcca acagggtcag   3300

tgtcacagcc acaacttcag aaagcagcca tcccgcgtgt cgtccaaaca gcagtgcctg   3360

cgtcccgctc cacggagtct tccagaacac ctccctctga actaatcccg gagcacccca   3420

cccccagcga gtcccacctg gacctcttca aagtcaaaac tcttctctcg ggacaaacaa   3480

atattcggga ctttcgaagc cctgaacttg agacaccaag tttgtctcca tggaaacacg   3540

tagccgctgc agttggacag ctgcgtgctg gagttctgtc cccaaaccaa ctgcagagaa   3600

gaaagacgag cctcggccca ggacgcgatt tctaacgaaa tgcaatagtt ttctcttttt   3660

ggaaaaatgt ttataccaat agttttgtgc gctaattgtt attagaacgt ttcttatgaa   3720

tgtgtacatt gcagtatatt cagtcccaaa tgttttgttc tcattcacac agaaggtact   3780

aatgtcagct cacgtggcct ttaaaaacct acttccccgc ccgcaggagc tcagagcatc   3840

gctgggcctg cgccagagtg aggggtgcag gaagacaaag acgcgtgctc actttagaaa   3900

cgaaaagctg ggaataatca cactgtttgt ctggtcgtat agcccaaacc ttagttgaaa   3960

tcagacagaa agaatgtctt taaaatatac atctcctctc cttggagaca ctgaagctca   4020

cagttaacgg attgtaatgc ccggcttttc ctcactcctg gtaaccaata caagctggtt   4080

tctgccttag gctctggcct gtctttccga tccacgagga ggaacagagg tggcagcgaa   4140

gccacaagcc tctcaggcct ggtctcattt ttcatagcag taaacaca                4188


<210>  3498
<211>  723
<212>  PRT
<213>  Homo sapiens

<400>  3498


Met Gln Asn Ser Glu Gly Gly Ala Asp Ser Pro Ala Ser Val Ala Leu 
1               5                   10                  15      


Arg Pro Ser Ala Ala Ala Pro Pro Val Pro Ala Ser Pro Gln Arg Val 
            20                  25                  30          


Leu Val Gln Ala Ala Ser Ser Asn Pro Lys Gly Ala Gln Met Gln Pro 
        35                  40                  45              


Ile Ser Leu Pro Arg Val Gln Gln Val Pro Gln Gln Val Gln Pro Val 
    50                  55                  60                  


Gln His Val Tyr Pro Ala Gln Val Gln Tyr Val Glu Gly Gly Asp Ala 
65                  70                  75                  80  


Val Tyr Thr Asn Gly Ala Ile Arg Thr Ala Tyr Thr Tyr Asn Pro Glu 
                85                  90                  95      


Pro Gln Met Tyr Ala Pro Ser Ser Thr Ala Ser Tyr Phe Glu Ala Pro 
            100                 105                 110         


Gly Gly Ala Gln Val Thr Val Ala Ala Ser Ser Pro Pro Ala Val Pro 
        115                 120                 125             


Ser His Ser Met Val Gly Ile Thr Met Asp Val Gly Gly Ser Pro Ile 
    130                 135                 140                 


Val Ser Ser Ala Gly Ala Tyr Leu Ile His Gly Gly Met Asp Ser Thr 
145                 150                 155                 160 


Arg His Ser Leu Ala His Thr Ser Arg Ser Ser Pro Ala Thr Leu Glu 
                165                 170                 175     


Met Ala Ile Glu Asn Leu Gln Lys Ser Glu Gly Ile Thr Ser His Lys 
            180                 185                 190         


Ser Gly Leu Leu Asn Ser His Leu Gln Trp Leu Leu Asp Asn Tyr Glu 
        195                 200                 205             


Thr Ala Glu Gly Val Ser Leu Pro Arg Ser Ser Leu Tyr Asn His Tyr 
    210                 215                 220                 


Leu Arg His Cys Gln Glu His Lys Leu Asp Pro Val Asn Ala Ala Ser 
225                 230                 235                 240 


Phe Gly Lys Leu Ile Arg Ser Val Phe Met Gly Leu Arg Thr Arg Arg 
                245                 250                 255     


Leu Gly Thr Arg Gly Asn Ser Lys Tyr His Tyr Tyr Gly Ile Arg Leu 
            260                 265                 270         


Lys Pro Asp Ser Pro Leu Asn Arg Leu Gln Glu Asp Thr Gln Tyr Met 
        275                 280                 285             


Ala Met Arg Gln Gln Pro Met His Gln Lys Pro Arg Tyr Arg Pro Ala 
    290                 295                 300                 


Gln Lys Thr Asp Ser Leu Gly Asp Ser Gly Ser His Ser Gly Leu His 
305                 310                 315                 320 


Ser Thr Pro Glu Gln Thr Met Ala Val Gln Ser Gln His His Gln Gln 
                325                 330                 335     


Tyr Ile Asp Val Ser His Val Phe Pro Glu Phe Pro Ala Pro Asp Leu 
            340                 345                 350         


Gly Ser Phe Leu Leu Gln Asp Gly Val Thr Leu His Asp Val Lys Ala 
        355                 360                 365             


Leu Gln Leu Val Tyr Arg Arg His Cys Glu Ala Thr Val Asp Val Val 
    370                 375                 380                 


Met Asn Leu Gln Phe His Tyr Ile Glu Lys Leu Trp Leu Ser Phe Trp 
385                 390                 395                 400 


Asn Ser Lys Ala Ser Ser Ser Asp Gly Pro Thr Ser Leu Pro Ala Ser 
                405                 410                 415     


Asp Glu Asp Pro Glu Gly Ala Val Leu Pro Lys Asp Lys Leu Ile Ser 
            420                 425                 430         


Leu Cys Gln Cys Asp Pro Ile Leu Arg Trp Met Arg Ser Cys Asp His 
        435                 440                 445             


Ile Leu Tyr Gln Ala Leu Val Glu Ile Leu Ile Pro Asp Val Leu Arg 
    450                 455                 460                 


Pro Val Pro Ser Thr Leu Thr Gln Ala Ile Arg Asn Phe Ala Lys Ser 
465                 470                 475                 480 


Leu Glu Gly Trp Leu Thr Asn Ala Met Ser Asp Phe Pro Gln Gln Val 
                485                 490                 495     


Ile Gln Thr Lys Val Gly Val Val Ser Ala Phe Ala Gln Thr Leu Arg 
            500                 505                 510         


Arg Tyr Thr Ser Leu Asn His Leu Ala Gln Ala Ala Arg Ala Val Leu 
        515                 520                 525             


Gln Asn Thr Ser Gln Ile Asn Gln Met Leu Ser Asp Leu Asn Arg Val 
    530                 535                 540                 


Asp Phe Ala Asn Val Gln Glu Gln Ala Ser Trp Val Cys Gln Cys Glu 
545                 550                 555                 560 


Glu Ser Val Val Gln Arg Leu Glu Gln Asp Phe Lys Leu Thr Leu Gln 
                565                 570                 575     


Gln Gln Ser Ser Leu Asp Gln Trp Ala Ser Trp Leu Asp Ser Val Val 
            580                 585                 590         


Thr Gln Val Leu Lys Gln His Ala Gly Ser Pro Ser Phe Pro Lys Ala 
        595                 600                 605             


Ala Arg Gln Phe Leu Leu Lys Trp Ser Phe Tyr Ser Ser Met Val Ile 
    610                 615                 620                 


Arg Asp Leu Thr Leu Arg Ser Ala Ala Ser Phe Gly Ser Phe His Leu 
625                 630                 635                 640 


Ile Arg Leu Leu Tyr Asp Glu Tyr Met Phe Tyr Leu Val Glu His Arg 
                645                 650                 655     


Val Ala Glu Ala Thr Gly Glu Thr Pro Ile Ala Val Met Gly Glu Phe 
            660                 665                 670         


Asn Asp Leu Ala Ser Leu Ser Leu Thr Leu Leu Asp Lys Asp Asp Met 
        675                 680                 685             


Gly Asp Glu Gln Arg Gly Ser Glu Ala Gly Pro Asp Ala Arg Ser Leu 
    690                 695                 700                 


Gly Glu Pro Leu Val Lys Arg Glu Arg Ser Asp Pro Asn His Ser Leu 
705                 710                 715                 720 


Gln Gly Ile 
            

<210>  3499
<211>  4113
<212>  DNA
<213>  Homo sapiens

<400>  3499
aaggtggggc gcggagcctg gtaaccgttg ccggtaacaa cgccccgccc cgtcgggcgg     60

gcgggctgcg cgaggctggc tggcggcggg agccggagga ggagcggccg ccgccgccac    120

cgccgccgcc atagagactg tagccgtgga gactgttact taccaacggg gaccaacacg    180

cagcagccgc tgccgccgcc gcgggagccg ctgcccgaac tcccggcccg aactccagac    240

ctgagcatgc agaattccga gggtggagcg gattcgccag cgtccgtggc tctgcgtccc    300

tcggcggcag ccccgcctgt gccagcctcc ccgcagaggg tgttggtcca ggcagccagc    360

tccaatccca aaggggccca gatgcagccg atctccctcc ccagagttca gcaggtaccc    420

cagcaggtgc agccggtgca gcacgtgtat cctgcccagg tgcagtacgt ggaaggggga    480

gacgccgtct acaccaatgg agccatacga acagcctaca cctacaaccc cgagcctcag    540

atgtacgccc ccagcagcac ggcttcttac ttcgaggccc caggcggtgc ccaggtgacc    600

gtggcagcct cgtccccgcc agcggtcccc tcccacagca tggtgggcat caccatggat    660

gtcgggggga gccccatcgt ctccagcgcg ggagcctatc tcatccacgg ggggatggac    720

agcaccagac actccctggc ccacacctcc cgctcatcgc ccgccacgct ccagtggctg    780

ttggataatt atgaaacagc ggaaggtgtg agtctcccca gaagttctct ttacaaccac    840

taccttcggc actgccagga gcacaagcta gacccagtga acgccgcctc cttcgggaaa    900

ctgatccgtt ctgtgtttat ggggctgaga acgcggcggc tgggcaccag gggcaactcg    960

aagtaccatt actatgggat tcgtctgaag ccggactcac cactgaaccg gctgcaggag   1020

gacacgcagt acatggccat gcggcagcag cccatgcacc agaagcccag gtaccggcca   1080

gcccagaaga cggacagcct cggggacagc ggctcccaca gcggcctgca cagcactccg   1140

gaacagacca tggccgtgca gagccagcac caccagcagt acatagatgt ctcccacgtc   1200

ttccccgagt tcccagcgcc cgacctgggc agcttcctgc tgcaggacgg cgtcacactg   1260

cacgacgtca aggccctgca gctggtgtac agacggcact gcgaggcaac tgtagatgtg   1320

gtgatgaacc tccagttcca ctacatcgag aagctgtggc tctccttctg gaactctaag   1380

gcctcctcca gcgacggccc cacctctctt cctgccagtg acgaagaccc cgagggcgcc   1440

gtcctgccca aggacaagct tatctccctg tgtcagtgcg accccatcct caggtggatg   1500

aggagctgcg accacatcct ctaccaggcg ctggtggaga ttctcatccc cgacgtgctg   1560

aggccggtcc ccagtacctt gacacaggcc atccgtaact ttgccaagag cttggaaggc   1620

tggttgacaa atgccatgag tgacttccca caacaggtca tccagaccaa ggtgggcgtc   1680

gtcagtgcct tcgcccagac gctgcggcgc tacacgtccc tcaaccacct ggcgcaggcg   1740

gcccgggcgg tgctgcagaa cacgtcccag atcaaccaga tgctcagcga cctcaaccgc   1800

gtggactttg ccaacgtgca ggagcaggcc tcgtgggtgt gccagtgcga ggagagtgtg   1860

gtgcagcggc tggagcagga tttcaagctg accctgcagc agcagagctc cctggaccag   1920

tgggccagct ggctggacag tgtggtcacc caggtcctga agcagcatgc cggcagcccc   1980

agcttcccca aggccgcccg gcagttcttg ctgaaatggt ccttttacag ctccatggtg   2040

atccgggacc tgaccctgcg cagcgctgcc agcttcggct ccttccacct catccgcctg   2100

ctctacgacg agtacatgtt ctacctggtg gagcaccgcg tcgcggaggc caccggagag   2160

acgccgatcg ctgtgatggg agagttcaac gatctcgcct ctctgtcgct gacgctgctc   2220

gacaaagatg acatgggcga tgagcagcgt ggcagcgagg cgggcccaga cgcccgcagc   2280

ctgggtgagc ccctggtaaa gcgggagcgc agtgacccca accactccct gcagggcatc   2340

tagcagcccc ggccggcgcc tcctcgaggt tccaaaagat gccgcctggt cactctggga   2400

acctggattt caccggctcc accaaattag tgcctcttag atgatgtgat gtttactttg   2460

actcaagcgg gggctcccgg ggtcagtgtt caagaaggaa agcagttgtt gaagctacag   2520

aagcccaggc cagggctccc actggctgta gctgtgctct gggtccccag gtccctgcgc   2580

agccaccagg gccccaccag accatgggtt ccttattctg gacaaaccct cctctgctgg   2640

aaccctggac tttggcccca gtccctttaa gagctgaaag ggctgtgctg agagcactgg   2700

cctctgcact caactggaac caattttcac catgatttta aaaattaaaa aaacctggca   2760

gagcccgact agaaagggac ggcctctccc ctcctacctg ccaccgctgg ggaggcacag   2820

agctcgccag cgtccctgga gtcccctcag gaatggaaag tggagtgccc ttgtctggta   2880

gcaccatgtg ggagggaccc agctgggcgc agcgccctgt ggccttttag atccagacct   2940

ccctgccgga tgccccgagg cgggaggccg gctgtgctgc aggaacccat ctccagatgc   3000

caaaggactt gaggggcagc tgacaatcgc tgtgtcccgg cagatccgca gctcgaaaaa   3060

gaacaagcca cagaaacggg ctcgctcgtg ccaggacaca gcagtgtctt tcaaaaaatc   3120

aaaaccagaa gttttatcag cagcaggaag gatgtgggac tctgtccaag ttcaccgtca   3180

ccatcaagcc actggctgtg gaaggagttt gtccaacagg gtcagtgtca cagccacaac   3240

ttcagaaagc agccatcccg cgtgtcgtcc aaacagcagt gcctgcgtcc cgctccacgg   3300

agtcttccag aacacctccc tctgaactaa tcccggagca ccccaccccc agcgagtccc   3360

acctggacct cttcaaagtc aaaactcttc tctcgggaca aacaaatatt cgggactttc   3420

gaagccctga acttgagaca ccaagtttgt ctccatggaa acacgtagcc gctgcagttg   3480

gacagctgcg tgctggagtt ctgtccccaa accaactgca gagaagaaag acgagcctcg   3540

gcccaggacg cgatttctaa cgaaatgcaa tagttttctc tttttggaaa aatgtttata   3600

ccaatagttt tgtgcgctaa ttgttattag aacgtttctt atgaatgtgt acattgcagt   3660

atattcagtc ccaaatgttt tgttctcatt cacacagaag gtactaatgt cagctcacgt   3720

ggcctttaaa aacctacttc cccgcccgca ggagctcaga gcatcgctgg gcctgcgcca   3780

gagtgagggg tgcaggaaga caaagacgcg tgctcacttt agaaacgaaa agctgggaat   3840

aatcacactg tttgtctggt cgtatagccc aaaccttagt tgaaatcaga cagaaagaat   3900

gtctttaaaa tatacatctc ctctccttgg agacactgaa gctcacagtt aacggattgt   3960

aatgcccggc ttttcctcac tcctggtaac caatacaagc tggtttctgc cttaggctct   4020

ggcctgtctt tccgatccac gaggaggaac agaggtggca gcgaagccac aagcctctca   4080

ggcctggtct catttttcat agcagtaaac aca                                4113


<210>  3500
<211>  698
<212>  PRT
<213>  Homo sapiens

<400>  3500


Met Gln Asn Ser Glu Gly Gly Ala Asp Ser Pro Ala Ser Val Ala Leu 
1               5                   10                  15      


Arg Pro Ser Ala Ala Ala Pro Pro Val Pro Ala Ser Pro Gln Arg Val 
            20                  25                  30          


Leu Val Gln Ala Ala Ser Ser Asn Pro Lys Gly Ala Gln Met Gln Pro 
        35                  40                  45              


Ile Ser Leu Pro Arg Val Gln Gln Val Pro Gln Gln Val Gln Pro Val 
    50                  55                  60                  


Gln His Val Tyr Pro Ala Gln Val Gln Tyr Val Glu Gly Gly Asp Ala 
65                  70                  75                  80  


Val Tyr Thr Asn Gly Ala Ile Arg Thr Ala Tyr Thr Tyr Asn Pro Glu 
                85                  90                  95      


Pro Gln Met Tyr Ala Pro Ser Ser Thr Ala Ser Tyr Phe Glu Ala Pro 
            100                 105                 110         


Gly Gly Ala Gln Val Thr Val Ala Ala Ser Ser Pro Pro Ala Val Pro 
        115                 120                 125             


Ser His Ser Met Val Gly Ile Thr Met Asp Val Gly Gly Ser Pro Ile 
    130                 135                 140                 


Val Ser Ser Ala Gly Ala Tyr Leu Ile His Gly Gly Met Asp Ser Thr 
145                 150                 155                 160 


Arg His Ser Leu Ala His Thr Ser Arg Ser Ser Pro Ala Thr Leu Gln 
                165                 170                 175     


Trp Leu Leu Asp Asn Tyr Glu Thr Ala Glu Gly Val Ser Leu Pro Arg 
            180                 185                 190         


Ser Ser Leu Tyr Asn His Tyr Leu Arg His Cys Gln Glu His Lys Leu 
        195                 200                 205             


Asp Pro Val Asn Ala Ala Ser Phe Gly Lys Leu Ile Arg Ser Val Phe 
    210                 215                 220                 


Met Gly Leu Arg Thr Arg Arg Leu Gly Thr Arg Gly Asn Ser Lys Tyr 
225                 230                 235                 240 


His Tyr Tyr Gly Ile Arg Leu Lys Pro Asp Ser Pro Leu Asn Arg Leu 
                245                 250                 255     


Gln Glu Asp Thr Gln Tyr Met Ala Met Arg Gln Gln Pro Met His Gln 
            260                 265                 270         


Lys Pro Arg Tyr Arg Pro Ala Gln Lys Thr Asp Ser Leu Gly Asp Ser 
        275                 280                 285             


Gly Ser His Ser Gly Leu His Ser Thr Pro Glu Gln Thr Met Ala Val 
    290                 295                 300                 


Gln Ser Gln His His Gln Gln Tyr Ile Asp Val Ser His Val Phe Pro 
305                 310                 315                 320 


Glu Phe Pro Ala Pro Asp Leu Gly Ser Phe Leu Leu Gln Asp Gly Val 
                325                 330                 335     


Thr Leu His Asp Val Lys Ala Leu Gln Leu Val Tyr Arg Arg His Cys 
            340                 345                 350         


Glu Ala Thr Val Asp Val Val Met Asn Leu Gln Phe His Tyr Ile Glu 
        355                 360                 365             


Lys Leu Trp Leu Ser Phe Trp Asn Ser Lys Ala Ser Ser Ser Asp Gly 
    370                 375                 380                 


Pro Thr Ser Leu Pro Ala Ser Asp Glu Asp Pro Glu Gly Ala Val Leu 
385                 390                 395                 400 


Pro Lys Asp Lys Leu Ile Ser Leu Cys Gln Cys Asp Pro Ile Leu Arg 
                405                 410                 415     


Trp Met Arg Ser Cys Asp His Ile Leu Tyr Gln Ala Leu Val Glu Ile 
            420                 425                 430         


Leu Ile Pro Asp Val Leu Arg Pro Val Pro Ser Thr Leu Thr Gln Ala 
        435                 440                 445             


Ile Arg Asn Phe Ala Lys Ser Leu Glu Gly Trp Leu Thr Asn Ala Met 
    450                 455                 460                 


Ser Asp Phe Pro Gln Gln Val Ile Gln Thr Lys Val Gly Val Val Ser 
465                 470                 475                 480 


Ala Phe Ala Gln Thr Leu Arg Arg Tyr Thr Ser Leu Asn His Leu Ala 
                485                 490                 495     


Gln Ala Ala Arg Ala Val Leu Gln Asn Thr Ser Gln Ile Asn Gln Met 
            500                 505                 510         


Leu Ser Asp Leu Asn Arg Val Asp Phe Ala Asn Val Gln Glu Gln Ala 
        515                 520                 525             


Ser Trp Val Cys Gln Cys Glu Glu Ser Val Val Gln Arg Leu Glu Gln 
    530                 535                 540                 


Asp Phe Lys Leu Thr Leu Gln Gln Gln Ser Ser Leu Asp Gln Trp Ala 
545                 550                 555                 560 


Ser Trp Leu Asp Ser Val Val Thr Gln Val Leu Lys Gln His Ala Gly 
                565                 570                 575     


Ser Pro Ser Phe Pro Lys Ala Ala Arg Gln Phe Leu Leu Lys Trp Ser 
            580                 585                 590         


Phe Tyr Ser Ser Met Val Ile Arg Asp Leu Thr Leu Arg Ser Ala Ala 
        595                 600                 605             


Ser Phe Gly Ser Phe His Leu Ile Arg Leu Leu Tyr Asp Glu Tyr Met 
    610                 615                 620                 


Phe Tyr Leu Val Glu His Arg Val Ala Glu Ala Thr Gly Glu Thr Pro 
625                 630                 635                 640 


Ile Ala Val Met Gly Glu Phe Asn Asp Leu Ala Ser Leu Ser Leu Thr 
                645                 650                 655     


Leu Leu Asp Lys Asp Asp Met Gly Asp Glu Gln Arg Gly Ser Glu Ala 
            660                 665                 670         


Gly Pro Asp Ala Arg Ser Leu Gly Glu Pro Leu Val Lys Arg Glu Arg 
        675                 680                 685             


Ser Asp Pro Asn His Ser Leu Gln Gly Ile 
    690                 695             

<210>  3501
<211>  2145
<212>  DNA
<213>  Homo sapiens

<400>  3501
gcccgtcagc ccccgcgtag gcctgcacgt cttaggatca ctcagcctct gggttcccca     60

gggaacgtag agcagggggt gtgttgctgc catgaagtct ggcctggggc ccgggttcca    120

tgctcccctg agggtcccca gcctctgtcc gcttgtcccc agctccatgg tgatccggga    180

cctgaccctg cgcagcgctg ccagcttcgg ctccttccac ctcatccgcc tgctctacga    240

cgagtacatg ttctacctgg tggagcaccg cgtcgcggag gccaccggag agacgccgat    300

cgctgtgatg ggagagttca acgatctcgc ctctctgtcg ctgacgctgc tcgacaaaga    360

tgacatgggc gatgagcagc gtggcagcga ggcgggccca gacgcccgca gcctgggtga    420

gcccctggta aagcgggagc gcagtgaccc caaccactcc ctgcagggca tctagcagcc    480

ccggccggcg cctcctcgag gttccaaaag atgccgcctg gtcactctgg gaacctggat    540

ttcaccggct ccaccaaatt agtgcctctt agatgatgtg atgtttactt tgactcaagc    600

gggggctccc ggggtcagtg ttcaagaagg aaagcagttg ttgaagctac agaagcccag    660

gccagggctc ccactggctg tagctgtgct ctgggtcccc aggtccctgc gcagccacca    720

gggccccacc agaccatggg ttccttattc tggacaaacc ctcctctgct ggaaccctgg    780

actttggccc cagtcccttt aagagctgaa agggctgtgc tgagagcact ggcctctgca    840

ctcaactgga accaattttc accatgattt taaaaattaa aaaaacctgg cagagcccga    900

ctagaaaggg acggcctctc ccctcctacc tgccaccgct ggggaggcac agagctcgcc    960

agcgtccctg gagtcccctc aggaatggaa agtggagtgc ccttgtctgg tagcaccatg   1020

tgggagggac ccagctgggc gcagcgccct gtggcctttt agatccagac ctccctgccg   1080

gatgccccga ggcgggaggc cggctgtgct gcaggaaccc atctccagat gccaaaggac   1140

ttgaggggca gctgacaatc gctgtgtccc ggcagatccg cagctcgaaa aagaacaagc   1200

cacagaaacg ggctcgctcg tgccaggaca cagcagtgtc tttcaaaaaa tcaaaaccag   1260

aagttttatc agcagcagga aggatgtggg actctgtcca agttcaccgt caccatcaag   1320

ccactggctg tggaaggagt ttgtccaaca gggtcagtgt cacagccaca acttcagaaa   1380

gcagccatcc cgcgtgtcgt ccaaacagca gtgcctgcgt cccgctccac ggagtcttcc   1440

agaacacctc cctctgaact aatcccggag caccccaccc ccagcgagtc ccacctggac   1500

ctcttcaaag tcaaaactct tctctcggga caaacaaata ttcgggactt tcgaagccct   1560

gaacttgaga caccaagttt gtctccatgg aaacacgtag ccgctgcagt tggacagctg   1620

cgtgctggag ttctgtcccc aaaccaactg cagagaagaa agacgagcct cggcccagga   1680

cgcgatttct aacgaaatgc aatagttttc tctttttgga aaaatgttta taccaatagt   1740

tttgtgcgct aattgttatt agaacgtttc ttatgaatgt gtacattgca gtatattcag   1800

tcccaaatgt tttgttctca ttcacacaga aggtactaat gtcagctcac gtggccttta   1860

aaaacctact tccccgcccg caggagctca gagcatcgct gggcctgcgc cagagtgagg   1920

ggtgcaggaa gacaaagacg cgtgctcact ttagaaacga aaagctggga ataatcacac   1980

tgtttgtctg gtcgtatagc ccaaacctta gttgaaatca gacagaaaga atgtctttaa   2040

aatatacatc tcctctcctt ggagacactg aagctcacag ttaacggatt gtaatgcccg   2100

gcttttcctc actcctggta accaatacaa gctggtttct gcctt                   2145


<210>  3502
<211>  127
<212>  PRT
<213>  Homo sapiens

<400>  3502


Met Lys Ser Gly Leu Gly Pro Gly Phe His Ala Pro Leu Arg Val Pro 
1               5                   10                  15      


Ser Leu Cys Pro Leu Val Pro Ser Ser Met Val Ile Arg Asp Leu Thr 
            20                  25                  30          


Leu Arg Ser Ala Ala Ser Phe Gly Ser Phe His Leu Ile Arg Leu Leu 
        35                  40                  45              


Tyr Asp Glu Tyr Met Phe Tyr Leu Val Glu His Arg Val Ala Glu Ala 
    50                  55                  60                  


Thr Gly Glu Thr Pro Ile Ala Val Met Gly Glu Phe Asn Asp Leu Ala 
65                  70                  75                  80  


Ser Leu Ser Leu Thr Leu Leu Asp Lys Asp Asp Met Gly Asp Glu Gln 
                85                  90                  95      


Arg Gly Ser Glu Ala Gly Pro Asp Ala Arg Ser Leu Gly Glu Pro Leu 
            100                 105                 110         


Val Lys Arg Glu Arg Ser Asp Pro Asn His Ser Leu Gln Gly Ile 
        115                 120                 125         

<210>  3503
<211>  4661
<212>  DNA
<213>  Homo sapiens

<400>  3503
aattagctgg gtgtggtggc acatgcctat aatcccagct actcaggagg ctgaggcatg     60

agaatcactt gagcctagga ggcagaggtg gccctgagcc gagatcacat cactgcactc    120

cagcctggga aacagagtaa gactctggct caagaaaaag ataagtaaat aaagctcttt    180

ttcaggggtg ggtggtgaaa tctcaaaatt ttgtaatagt gtatttttta atagaccaaa    240

tgattgagac ccactatgtt ggagagacag tgttttcttc tccttcccag tctgctgggc    300

actggacaag gccccctgag attagggcag acttccagag gtcatgcact ctgctctccc    360

ggcacccata ggtgagcgat gtcccacagg gaaggtgcca cagggcagta ctcacgtggc    420

tgcccaagct gcagatcaga atggccccaa gacatggggg tggcatgtgt gttttttcta    480

tcatagaggt ggcgattgcc ttctcatcgc ctgcaccctg aggctgatgg gtgggagagg    540

tctcaccatc ctactttccc ctggtcctcc agtgtacctt ctgcacttct taaaggtgac    600

cctgacgtcc tccttggctt gaagcaaggg tagctaatga gagaaggcag aaccaccgtg    660

gtcggaggcc gtgggagaag cagttaccct ctcattcttg aactcagctc cgctcgcctg    720

ctctctgaaa tacacactca acctgctctt tgcagaagtg tcaagtcttt ggcctcctta    780

agaaaggaag catatacttc aagttcatct cctcccgctt cagtcctctg gtcgtcaggg    840

tgggctgcag cagattttac gtcgctgttt tccgtgtgcg agtctaggac aaaccaaatg    900

cgtgcgaatg ccttagtggc cacgcacagc tgtgtgcctc ctccatcgcg tggacctgcc    960

gcccacctcc ctccccacct ccatcaggtc cttcaggatc caactcaaaa gccccttcct   1020

ccaggaagtt ctgctgttag ctgcccaact ctttcttcca aaactctttt ctcttttcca   1080

aaaatcttct tcgcacagct cccactgggt aaacattcgc cagacagtgt ccagtggccc   1140

tggatcctac ggcctcctgg tggcagggtc tgagtctttg gcctcgctgc tattttccca   1200

aagcctccag cagcggggag accctgggat ttgcgacagg acagcctggc tggggagtca   1260

aggctgccat ctctccttgc tttcattctg gttccccatc gatgtggcgt ggggaaagga   1320

gcaggtgact atgatgctgg cttggctgac actggaatgg atgcagtggc tgcatattaa   1380

tgctacggcg tgcacacaca tatgccaggt taaagttcag tagcaagttt ttacaacatg   1440

atttctgctg cttctgttgg acgggctctc gggcttacct acgtgtgcga agcaacactc   1500

cctaccgcag ctttcatgca caatttaact cacccccgcc ctgcctgcgt ggagcctcat   1560

ttttattttg taggagctcg aatcattatt tggatattaa taaaaacaaa tcttggctga   1620

tgctaaccat ctgatttcct tttttttttt ttccattttg ttttgttttg tttctgcaca   1680

cattttcttt agcttgaaat ggcgattgaa aacctccaaa aaagcgaagg aatcacatca   1740

cacaaaagcg gtttactcaa cagccatctc cagtggctgt tggataatta tgaaacagcg   1800

gaaggtgtga gtctccccag aagttctctt tacaaccact accttcggca ctgccaggag   1860

cacaagctag acccagtgaa cgccgcctcc ttcgggaaac tgatccgttc tgtgtttatg   1920

gggctgagaa cgcggcggct gggcaccagg tgggcaactg tagatgtggt gatgaacctc   1980

cagttccact acatcgagaa gctgtggctc tccttctgga actctaaggc ctcctccagc   2040

gacggcccca cctctcttcc tgccagtgac gaagaccccg agggcgccgt cctgcccaag   2100

gacaagctta tctccctgtg tcagtgcgac cccatcctca ggtggatgag gagctgcgac   2160

cacatcctct accaggcgct ggtggagatt ctcatccccg acgtgctgag gccggtcccc   2220

agtaccttga cacaggccat ccgtaacttt gccaagagct tggaaggctg gttgacaaat   2280

gccatgagtg acttcccaca acaggtcatc cagaccaagg tgggcgtcgt cagtgccttc   2340

gcccagacgc tgcggcgcta cacgtccctc aaccacctgg cgcaggcggc ccgggcggtg   2400

ctgcagaaca cgtcccagat caaccagatg ctcagcgacc tcaaccgcgt ggactttgcc   2460

aacgtgcagg agcaggcctc gtgggtgtgc cagtgcgagg agagtgtggt gcagcggctg   2520

gagcaggatt tcaagctgac cctgcagcag cagagctccc tggaccagtg ggccagctgg   2580

ctggacagtg tggtcaccca ggtcctgaag cagcatgccg gcagccccag cttccccaag   2640

gccgcccggc agttcttgct gaaatggtcc ttttacagct ccatggtgat ccgggacctg   2700

accctgcgca gcgctgccag cttcggctcc ttccacctca tccgcctgct ctacgacgag   2760

tacatgttct acctggtgga gcaccgcgtc gcggaggcca ccggagagac gccgatcgct   2820

gtgatgggag agttcaacga tctcgcctct ctgtcgctga cgctgctcga caaagatgac   2880

atgggcgatg agcagcgtgg cagcgaggcg ggcccagacg cccgcagcct gggtgagccc   2940

ctggtaaagc gggagcgcag tgaccccaac cactccctgc agggcatcta gcagccccgg   3000

ccggcgcctc ctcgaggttc caaaagatgc cgcctggtca ctctgggaac ctggatttca   3060

ccggctccac caaattagtg cctcttagat gatgtgatgt ttactttgac tcaagcgggg   3120

gctcccgggg tcagtgttca agaaggaaag cagttgttga agctacagaa gcccaggcca   3180

gggctcccac tggctgtagc tgtgctctgg gtccccaggt ccctgcgcag ccaccagggc   3240

cccaccagac catgggttcc ttattctgga caaaccctcc tctgctggaa ccctggactt   3300

tggccccagt ccctttaaga gctgaaaggg ctgtgctgag agcactggcc tctgcactca   3360

actggaacca attttcacca tgattttaaa aattaaaaaa acctggcaga gcccgactag   3420

aaagggacgg cctctcccct cctacctgcc accgctgggg aggcacagag ctcgccagcg   3480

tccctggagt cccctcagga atggaaagtg gagtgccctt gtctggtagc accatgtggg   3540

agggacccag ctgggcgcag cgccctgtgg ccttttagat ccagacctcc ctgccggatg   3600

ccccgaggcg ggaggccggc tgtgctgcag gaacccatct ccagatgcca aaggacttga   3660

ggggcagctg acaatcgctg tgtcccggca gatccgcagc tcgaaaaaga acaagccaca   3720

gaaacgggct cgctcgtgcc aggacacagc agtgtctttc aaaaaatcaa aaccagaagt   3780

tttatcagca gcaggaagga tgtgggactc tgtccaagtt caccgtcacc atcaagccac   3840

tggctgtgga aggagtttgt ccaacagggt cagtgtcaca gccacaactt cagaaagcag   3900

ccatcccgcg tgtcgtccaa acagcagtgc ctgcgtcccg ctccacggag tcttccagaa   3960

cacctccctc tgaactaatc ccggagcacc ccacccccag cgagtcccac ctggacctct   4020

tcaaagtcaa aactcttctc tcgggacaaa caaatattcg ggactttcga agccctgaac   4080

ttgagacacc aagtttgtct ccatggaaac acgtagccgc tgcagttgga cagctgcgtg   4140

ctggagttct gtccccaaac caactgcaga gaagaaagac gagcctcggc ccaggacgcg   4200

atttctaacg aaatgcaata gttttctctt tttggaaaaa tgtttatacc aatagttttg   4260

tgcgctaatt gttattagaa cgtttcttat gaatgtgtac attgcagtat attcagtccc   4320

aaatgttttg ttctcattca cacagaaggt actaatgtca gctcacgtgg cctttaaaaa   4380

cctacttccc cgcccgcagg agctcagagc atcgctgggc ctgcgccaga gtgaggggtg   4440

caggaagaca aagacgcgtg ctcactttag aaacgaaaag ctgggaataa tcacactgtt   4500

tgtctggtcg tatagcccaa accttagttg aaatcagaca gaaagaatgt ctttaaaata   4560

tacatctcct ctccttggag acactgaagc tcacagttaa cggattgtaa tgcccggctt   4620

ttcctcactc ctggtaacca atacaagctg gtttctgcct t                       4661


<210>  3504
<211>  430
<212>  PRT
<213>  Homo sapiens

<400>  3504


Met Ala Ile Glu Asn Leu Gln Lys Ser Glu Gly Ile Thr Ser His Lys 
1               5                   10                  15      


Ser Gly Leu Leu Asn Ser His Leu Gln Trp Leu Leu Asp Asn Tyr Glu 
            20                  25                  30          


Thr Ala Glu Gly Val Ser Leu Pro Arg Ser Ser Leu Tyr Asn His Tyr 
        35                  40                  45              


Leu Arg His Cys Gln Glu His Lys Leu Asp Pro Val Asn Ala Ala Ser 
    50                  55                  60                  


Phe Gly Lys Leu Ile Arg Ser Val Phe Met Gly Leu Arg Thr Arg Arg 
65                  70                  75                  80  


Leu Gly Thr Arg Trp Ala Thr Val Asp Val Val Met Asn Leu Gln Phe 
                85                  90                  95      


His Tyr Ile Glu Lys Leu Trp Leu Ser Phe Trp Asn Ser Lys Ala Ser 
            100                 105                 110         


Ser Ser Asp Gly Pro Thr Ser Leu Pro Ala Ser Asp Glu Asp Pro Glu 
        115                 120                 125             


Gly Ala Val Leu Pro Lys Asp Lys Leu Ile Ser Leu Cys Gln Cys Asp 
    130                 135                 140                 


Pro Ile Leu Arg Trp Met Arg Ser Cys Asp His Ile Leu Tyr Gln Ala 
145                 150                 155                 160 


Leu Val Glu Ile Leu Ile Pro Asp Val Leu Arg Pro Val Pro Ser Thr 
                165                 170                 175     


Leu Thr Gln Ala Ile Arg Asn Phe Ala Lys Ser Leu Glu Gly Trp Leu 
            180                 185                 190         


Thr Asn Ala Met Ser Asp Phe Pro Gln Gln Val Ile Gln Thr Lys Val 
        195                 200                 205             


Gly Val Val Ser Ala Phe Ala Gln Thr Leu Arg Arg Tyr Thr Ser Leu 
    210                 215                 220                 


Asn His Leu Ala Gln Ala Ala Arg Ala Val Leu Gln Asn Thr Ser Gln 
225                 230                 235                 240 


Ile Asn Gln Met Leu Ser Asp Leu Asn Arg Val Asp Phe Ala Asn Val 
                245                 250                 255     


Gln Glu Gln Ala Ser Trp Val Cys Gln Cys Glu Glu Ser Val Val Gln 
            260                 265                 270         


Arg Leu Glu Gln Asp Phe Lys Leu Thr Leu Gln Gln Gln Ser Ser Leu 
        275                 280                 285             


Asp Gln Trp Ala Ser Trp Leu Asp Ser Val Val Thr Gln Val Leu Lys 
    290                 295                 300                 


Gln His Ala Gly Ser Pro Ser Phe Pro Lys Ala Ala Arg Gln Phe Leu 
305                 310                 315                 320 


Leu Lys Trp Ser Phe Tyr Ser Ser Met Val Ile Arg Asp Leu Thr Leu 
                325                 330                 335     


Arg Ser Ala Ala Ser Phe Gly Ser Phe His Leu Ile Arg Leu Leu Tyr 
            340                 345                 350         


Asp Glu Tyr Met Phe Tyr Leu Val Glu His Arg Val Ala Glu Ala Thr 
        355                 360                 365             


Gly Glu Thr Pro Ile Ala Val Met Gly Glu Phe Asn Asp Leu Ala Ser 
    370                 375                 380                 


Leu Ser Leu Thr Leu Leu Asp Lys Asp Asp Met Gly Asp Glu Gln Arg 
385                 390                 395                 400 


Gly Ser Glu Ala Gly Pro Asp Ala Arg Ser Leu Gly Glu Pro Leu Val 
                405                 410                 415     


Lys Arg Glu Arg Ser Asp Pro Asn His Ser Leu Gln Gly Ile 
            420                 425                 430 

<210>  3505
<211>  4088
<212>  DNA
<213>  Homo sapiens

<400>  3505
aaggtggggc gcggagcctg gtaaccgttg ccggtaacaa cgccccgccc cgtcgggcgg     60

gcgggctgcg cgaggctggc tggcggcggg agccggagga ggagcggccg ccgccgccac    120

cgccgccgcc atagagactg tagccgtgga gactgttact taccaacggg gaccaacacg    180

cagcagccgc tgccgccgcc gcgggagccg ctgcccgaac tcccggcccg aactccagac    240

ctgagcatgc agaattccga gggtggagcg gattcgccag cgtccgtggc tctgcgtccc    300

tcggcggcag ccccgcctgt gccagcctcc ccgcagaggg tgttggtcca ggcagccagc    360

tccaatccca aaggggccca gatgcagccg atctccctcc ccagagttca gcaggtaccc    420

cagcaggtgc agccggtgca gcacgtgtat cctgcccagg tgcagtacgt ggaaggggga    480

gacgccgtct acaccaatgg agccatacga acagcctaca cctacaaccc cgagcctcag    540

atgtacgccc ccagcagcac ggcttcttac ttcgaggccc caggcggtgc ccaggtgacc    600

gtggcagcct cgtccccgcc agcggtcccc tcccacagca tggtgggcat caccatggat    660

gtcgggggga gccccatcgt ctccagcgcg ggagcctatc tcatccacgg ggggatggac    720

agcaccagac actccctggc ccacacctcc cgctcatcgc ccgccacgct tgaaatggcg    780

attgaaaacc tccaaaaaag cgaaggaatc acatcacaca aaagcggttt actcaacagc    840

catctccagt ggctgttgga taattatgaa acagcggaag gtgtgagtct ccccagaagt    900

tctctttaca accactacct tcggcactgc caggagcaca agctagaccc agtgaacgcc    960

gcctccttcg ggaaactgat ccgttctgtg tttatggggc tgagaacgcg gcggctgggc   1020

accaggggca actcgaagta ccattactat gggattcgtc tgaagccgga ctcaccactg   1080

aaccggctgc aggaggacac gcagtacatg gccatgcggc agcagcccat gcaccagaag   1140

cccaggtacc ggccagccca gaagacggac agcctcgggg acagcggctc ccacagcggc   1200

ctgcacagca ctccggaaca gaccatggcc gtgcagagcc agcaccacca gcagtacata   1260

gatgtctccc acgtcttccc cgagttccca gcgcccgacc tgggcagctt cctgctgcag   1320

gacggcgtca cactgcacga cgtcaaggcc ctgcagctgg tgtacagacg gcactgcgag   1380

gcaactgtag atgtggtgat gaacctccag ttccactaca tcgagaagct gtggctctcc   1440

ttctggaact ctaaggcctc ctccagcgac ggccccacct ctcttcctgc cagtgacgaa   1500

gaccccgagg gcgccgtcct gcccaaggac aagcttatct ccctgtgtca gtgcgacccc   1560

atcctcaggt ggatgaggag ctgcgaccac atcctctacc aggcgctggt ggagattctc   1620

atccccgacg tgctgaggcc ggtccccagt accttgacac aggccatccg taactttgcc   1680

aagagcttgg aaggctggtt gacaaatgcc atgagtgact tcccacaaca ggtcatccag   1740

accaaggtgg gcgtcgtcag tgccttcgcc cagacgctgc ggcgctacac gtccctcaac   1800

cacctggcgc aggcggcccg ggcggtgctg cagaacacgt cccagatcaa ccagatgctc   1860

agcgacctca accgcgtgga ctttgccaac gtgcaggagc aggcctcgtg ggtgtgccag   1920

tgcgaggaga gtgtggtgca gcggctggag caggatttca agctgaccct gcagcagcag   1980

agctccctgg accagtgggc cagctggctg gacagtgtgg tcacccaggt cctgaagcag   2040

catgccggca gccccagctt ccccaaggcc gcccggcagt tcttgctgaa atggtccttt   2100

tacagctcca tggtgatccg ggacctgacc ctgcgcagcg ctgccagctt cggctccttc   2160

cacctcatcc gcctgctcta cgacgagtac atgttctacc tggtggagca ccgcgtcgcg   2220

gaggccaccg gagagacgcc gatcgctgtg atgggagagt tcaacgatct cgcctctctg   2280

tcgctgacgc tgctcgacaa agatgacatg ggcgatgagc agcgtggcag cgaggcgggc   2340

ccagacgccc gcagcctggg tgagcccctg gtaaagcggg agcgcagtga ccccaaccac   2400

tccctgcagg gcatctagca gccccggccg gcgcctcctc gaggttccaa aagatgccgc   2460

ctggtcactc tgggaacctg gatttcaccg gctccaccaa attagtgcct cttagatgat   2520

gtgatgttta ctttgactca agcgggggct cccggggtca gtgttcaaga aggaaagcag   2580

ttgttgaagc tacagaagcc caggccaggg ctcccactgg ctgtagctgt gctctgggtc   2640

cccaggtccc tgcgcagcca ccagggcccc accagaccat gggttcctta ttctggacaa   2700

accctcctct gctggaaccc tggactttgg ccccagtccc tttaagagct gaaagggctg   2760

tgctgagagc actggcctct gcactcaact ggaaccaatt ttcaccatga ttttaaaaat   2820

taaaaaaacc tggcagagcc cgactagaaa gggacggcct ctcccctcct acctgccacc   2880

gctggggagg cacagagctc gccagcgtcc ctggagtccc ctcaggaatg gaaagtggag   2940

tgcccttgtc tggtagcacc atgtgggagg gacccagctg ggcgcagcgc cctgtggcct   3000

tttagatcca gacctccctg ccggatgccc cgaggcggga ggccggctgt gctgcaggaa   3060

cccatctcca gatgccaaag gacttgaggg gcagctgaca atcgctgtgt cccggcagat   3120

ccgcagctcg aaaaagaaca agccacagaa acgggctcgc tcgtgccagg acacagcagt   3180

gtctttcaaa aaatcaaaac cagaagtttt atcagcagca ggaaggatgt gggactctgt   3240

ccaagttcac cgtcaccatc aagccactgg ctgtggaagg agtttgtcca acagggtcag   3300

tgtcacagcc acaacttcag aaagcagcca tcccgcgtgt cgtccaaaca gcagtgcctg   3360

cgtcccgctc cacggagtct tccagaacac ctccctctga actaatcccg gagcacccca   3420

cccccagcga gtcccacctg gacctcttca aagtcaaaac tcttctctcg ggacaaacaa   3480

atattcggga ctttcgaagc cctgaacttg agacaccaag tttgtctcca tggaaacacg   3540

tagccgctgc agttggacag ctgcgtgctg gagttctgtc cccaaaccaa ctgcagagaa   3600

gaaagacgag cctcggccca ggacgcgatt tctaacgaaa tgcaatagtt ttctcttttt   3660

ggaaaaatgt ttataccaat agttttgtgc gctaattgtt attagaacgt ttcttatgaa   3720

tgtgtacatt gcagtatatt cagtcccaaa tgttttgttc tcattcacac agaaggtact   3780

aatgtcagct cacgtggcct ttaaaaacct acttccccgc ccgcaggagc tcagagcatc   3840

gctgggcctg cgccagagtg aggggtgcag gaagacaaag acgcgtgctc actttagaaa   3900

cgaaaagctg ggaataatca cactgtttgt ctggtcgtat agcccaaacc ttagttgaaa   3960

tcagacagaa agaatgtctt taaaatatac atctcctctc cttggagaca ctgaagctca   4020

cagttaacgg attgtaatgc ccggcttttc ctcactcctg gtaaccaata caagctggtt   4080

tctgcctt                                                            4088


<210>  3506
<211>  723
<212>  PRT
<213>  Homo sapiens

<400>  3506


Met Gln Asn Ser Glu Gly Gly Ala Asp Ser Pro Ala Ser Val Ala Leu 
1               5                   10                  15      


Arg Pro Ser Ala Ala Ala Pro Pro Val Pro Ala Ser Pro Gln Arg Val 
            20                  25                  30          


Leu Val Gln Ala Ala Ser Ser Asn Pro Lys Gly Ala Gln Met Gln Pro 
        35                  40                  45              


Ile Ser Leu Pro Arg Val Gln Gln Val Pro Gln Gln Val Gln Pro Val 
    50                  55                  60                  


Gln His Val Tyr Pro Ala Gln Val Gln Tyr Val Glu Gly Gly Asp Ala 
65                  70                  75                  80  


Val Tyr Thr Asn Gly Ala Ile Arg Thr Ala Tyr Thr Tyr Asn Pro Glu 
                85                  90                  95      


Pro Gln Met Tyr Ala Pro Ser Ser Thr Ala Ser Tyr Phe Glu Ala Pro 
            100                 105                 110         


Gly Gly Ala Gln Val Thr Val Ala Ala Ser Ser Pro Pro Ala Val Pro 
        115                 120                 125             


Ser His Ser Met Val Gly Ile Thr Met Asp Val Gly Gly Ser Pro Ile 
    130                 135                 140                 


Val Ser Ser Ala Gly Ala Tyr Leu Ile His Gly Gly Met Asp Ser Thr 
145                 150                 155                 160 


Arg His Ser Leu Ala His Thr Ser Arg Ser Ser Pro Ala Thr Leu Glu 
                165                 170                 175     


Met Ala Ile Glu Asn Leu Gln Lys Ser Glu Gly Ile Thr Ser His Lys 
            180                 185                 190         


Ser Gly Leu Leu Asn Ser His Leu Gln Trp Leu Leu Asp Asn Tyr Glu 
        195                 200                 205             


Thr Ala Glu Gly Val Ser Leu Pro Arg Ser Ser Leu Tyr Asn His Tyr 
    210                 215                 220                 


Leu Arg His Cys Gln Glu His Lys Leu Asp Pro Val Asn Ala Ala Ser 
225                 230                 235                 240 


Phe Gly Lys Leu Ile Arg Ser Val Phe Met Gly Leu Arg Thr Arg Arg 
                245                 250                 255     


Leu Gly Thr Arg Gly Asn Ser Lys Tyr His Tyr Tyr Gly Ile Arg Leu 
            260                 265                 270         


Lys Pro Asp Ser Pro Leu Asn Arg Leu Gln Glu Asp Thr Gln Tyr Met 
        275                 280                 285             


Ala Met Arg Gln Gln Pro Met His Gln Lys Pro Arg Tyr Arg Pro Ala 
    290                 295                 300                 


Gln Lys Thr Asp Ser Leu Gly Asp Ser Gly Ser His Ser Gly Leu His 
305                 310                 315                 320 


Ser Thr Pro Glu Gln Thr Met Ala Val Gln Ser Gln His His Gln Gln 
                325                 330                 335     


Tyr Ile Asp Val Ser His Val Phe Pro Glu Phe Pro Ala Pro Asp Leu 
            340                 345                 350         


Gly Ser Phe Leu Leu Gln Asp Gly Val Thr Leu His Asp Val Lys Ala 
        355                 360                 365             


Leu Gln Leu Val Tyr Arg Arg His Cys Glu Ala Thr Val Asp Val Val 
    370                 375                 380                 


Met Asn Leu Gln Phe His Tyr Ile Glu Lys Leu Trp Leu Ser Phe Trp 
385                 390                 395                 400 


Asn Ser Lys Ala Ser Ser Ser Asp Gly Pro Thr Ser Leu Pro Ala Ser 
                405                 410                 415     


Asp Glu Asp Pro Glu Gly Ala Val Leu Pro Lys Asp Lys Leu Ile Ser 
            420                 425                 430         


Leu Cys Gln Cys Asp Pro Ile Leu Arg Trp Met Arg Ser Cys Asp His 
        435                 440                 445             


Ile Leu Tyr Gln Ala Leu Val Glu Ile Leu Ile Pro Asp Val Leu Arg 
    450                 455                 460                 


Pro Val Pro Ser Thr Leu Thr Gln Ala Ile Arg Asn Phe Ala Lys Ser 
465                 470                 475                 480 


Leu Glu Gly Trp Leu Thr Asn Ala Met Ser Asp Phe Pro Gln Gln Val 
                485                 490                 495     


Ile Gln Thr Lys Val Gly Val Val Ser Ala Phe Ala Gln Thr Leu Arg 
            500                 505                 510         


Arg Tyr Thr Ser Leu Asn His Leu Ala Gln Ala Ala Arg Ala Val Leu 
        515                 520                 525             


Gln Asn Thr Ser Gln Ile Asn Gln Met Leu Ser Asp Leu Asn Arg Val 
    530                 535                 540                 


Asp Phe Ala Asn Val Gln Glu Gln Ala Ser Trp Val Cys Gln Cys Glu 
545                 550                 555                 560 


Glu Ser Val Val Gln Arg Leu Glu Gln Asp Phe Lys Leu Thr Leu Gln 
                565                 570                 575     


Gln Gln Ser Ser Leu Asp Gln Trp Ala Ser Trp Leu Asp Ser Val Val 
            580                 585                 590         


Thr Gln Val Leu Lys Gln His Ala Gly Ser Pro Ser Phe Pro Lys Ala 
        595                 600                 605             


Ala Arg Gln Phe Leu Leu Lys Trp Ser Phe Tyr Ser Ser Met Val Ile 
    610                 615                 620                 


Arg Asp Leu Thr Leu Arg Ser Ala Ala Ser Phe Gly Ser Phe His Leu 
625                 630                 635                 640 


Ile Arg Leu Leu Tyr Asp Glu Tyr Met Phe Tyr Leu Val Glu His Arg 
                645                 650                 655     


Val Ala Glu Ala Thr Gly Glu Thr Pro Ile Ala Val Met Gly Glu Phe 
            660                 665                 670         


Asn Asp Leu Ala Ser Leu Ser Leu Thr Leu Leu Asp Lys Asp Asp Met 
        675                 680                 685             


Gly Asp Glu Gln Arg Gly Ser Glu Ala Gly Pro Asp Ala Arg Ser Leu 
    690                 695                 700                 


Gly Glu Pro Leu Val Lys Arg Glu Arg Ser Asp Pro Asn His Ser Leu 
705                 710                 715                 720 


Gln Gly Ile 
            

<210>  3507
<211>  1804
<212>  DNA
<213>  Homo sapiens

<400>  3507
gcccgtcagc ccccgcgtag gcctgcacgt cttaggatca ctcagcctct gggttcccca     60

gggaacgtag agcagggggt gtgttgctgc catgaagtct ggcctggggc ccgggttcca    120

tgctcccctg agggtcccca gcctctgtcc gcttgtcccc agctccatgg tgatccggga    180

cctgaccctg cgcagcgctg ccagcttcgg ctccttccac ctcatccgcc tgctctacga    240

cgagtacatg ttctacctgg tggagcaccg cgtcgcggag gccaccggag agacgccgat    300

cgctgtgatg ggagagttca acgatctcgc ctctctgtcg ctgacgctgc tcgacaaaga    360

tgacatgggc gatgagcagc gtggcagcga ggcgggccca gacgcccgca gcctgggtga    420

gcccctggta aagcgggagc gcagtgaccc caaccactcc ctgcagggca tctagcagcc    480

ccggccggcg cctcctcgag gttccaaaag atgccgcctg gtcactctgg gaacctggat    540

ttcaccggct ccaccaaatt agtgcctctt agatgatgtg atgtttactt tgactcaagc    600

gggggctccc ggggtcagtg ttcaagaagg aaagcagttg ttgaagctac agaagcccag    660

gccagggctc ccactggctg tagctgtgct ctgggtcccc aggtccctgc gcagccacca    720

gggccccacc agaccatggg ttccttattc tggacaaacc ctcctctgct ggaaccctgg    780

actttggccc cagtcccttt aagagctgaa agggctgtgc tgagagcact ggcctctgca    840

ctcaactgga accaattttc accatgattt taaaaattaa aaaaacctgg cagagcccga    900

ctagaaaggg acggcctctc ccctcctacc tgccaccgct ggggaggcac agagctcgcc    960

agcgtccctg gagtcccctc aggaatggaa agtggagtgc ccttgtctgg tagcaccatg   1020

tgggagggac ccagctgggc gcagcgccct gtggcctttt agatccagac ctccctgccg   1080

gatgccccga ggcgggaggc cggctgtgct gcaggaaccc atctccagat gccaaaggac   1140

ttgaggggca gctgacaatc gctgtgtccc ggcagatccg cagctcgaaa aagaacaagc   1200

cacagaaacg ggctcgctcg tgccaggaca cagcagtgtc tttcaaaaaa tcaaaaccag   1260

aagttttatc agcagcagga aggatgtggg actctgtcca agttcaccgt caccatcaag   1320

ccactggctg tggaaggagt ttgtccaaca gggtcagtgt cacagccaca acttcagaaa   1380

gcagccatcc cgcgtgtcgt ccaaacagca gtgcctgcgt cccgctccac ggagtcttcc   1440

agaacacctc cctctgaact aatcccggag caccccaccc ccagcgagtc ccacctggac   1500

ctcttcaaag tcaaaactct tctctcggga caaacaaata ttcgggactt tcgaagccct   1560

gaacttgaga caccaagttt gtctccatgg aaacacgtag ccgctgcagt tggacagctg   1620

cgtgctggag ttctgtcccc aaaccaactg cagagaagaa agacgagcct cggcccagga   1680

cgcgatttct aacgaaatgc aatagttttc tctttttgga aaaatgttta taccaatagt   1740

tttgtgcgct aattgttatt agaacgtttc ttatgaatgt gtacattgca gtatattcag   1800

tccc                                                                1804


<210>  3508
<211>  127
<212>  PRT
<213>  Homo sapiens

<400>  3508


Met Lys Ser Gly Leu Gly Pro Gly Phe His Ala Pro Leu Arg Val Pro 
1               5                   10                  15      


Ser Leu Cys Pro Leu Val Pro Ser Ser Met Val Ile Arg Asp Leu Thr 
            20                  25                  30          


Leu Arg Ser Ala Ala Ser Phe Gly Ser Phe His Leu Ile Arg Leu Leu 
        35                  40                  45              


Tyr Asp Glu Tyr Met Phe Tyr Leu Val Glu His Arg Val Ala Glu Ala 
    50                  55                  60                  


Thr Gly Glu Thr Pro Ile Ala Val Met Gly Glu Phe Asn Asp Leu Ala 
65                  70                  75                  80  


Ser Leu Ser Leu Thr Leu Leu Asp Lys Asp Asp Met Gly Asp Glu Gln 
                85                  90                  95      


Arg Gly Ser Glu Ala Gly Pro Asp Ala Arg Ser Leu Gly Glu Pro Leu 
            100                 105                 110         


Val Lys Arg Glu Arg Ser Asp Pro Asn His Ser Leu Gln Gly Ile 
        115                 120                 125         

<210>  3509
<211>  4320
<212>  DNA
<213>  Homo sapiens

<400>  3509
aattagctgg gtgtggtggc acatgcctat aatcccagct actcaggagg ctgaggcatg     60

agaatcactt gagcctagga ggcagaggtg gccctgagcc gagatcacat cactgcactc    120

cagcctggga aacagagtaa gactctggct caagaaaaag ataagtaaat aaagctcttt    180

ttcaggggtg ggtggtgaaa tctcaaaatt ttgtaatagt gtatttttta atagaccaaa    240

tgattgagac ccactatgtt ggagagacag tgttttcttc tccttcccag tctgctgggc    300

actggacaag gccccctgag attagggcag acttccagag gtcatgcact ctgctctccc    360

ggcacccata ggtgagcgat gtcccacagg gaaggtgcca cagggcagta ctcacgtggc    420

tgcccaagct gcagatcaga atggccccaa gacatggggg tggcatgtgt gttttttcta    480

tcatagaggt ggcgattgcc ttctcatcgc ctgcaccctg aggctgatgg gtgggagagg    540

tctcaccatc ctactttccc ctggtcctcc agtgtacctt ctgcacttct taaaggtgac    600

cctgacgtcc tccttggctt gaagcaaggg tagctaatga gagaaggcag aaccaccgtg    660

gtcggaggcc gtgggagaag cagttaccct ctcattcttg aactcagctc cgctcgcctg    720

ctctctgaaa tacacactca acctgctctt tgcagaagtg tcaagtcttt ggcctcctta    780

agaaaggaag catatacttc aagttcatct cctcccgctt cagtcctctg gtcgtcaggg    840

tgggctgcag cagattttac gtcgctgttt tccgtgtgcg agtctaggac aaaccaaatg    900

cgtgcgaatg ccttagtggc cacgcacagc tgtgtgcctc ctccatcgcg tggacctgcc    960

gcccacctcc ctccccacct ccatcaggtc cttcaggatc caactcaaaa gccccttcct   1020

ccaggaagtt ctgctgttag ctgcccaact ctttcttcca aaactctttt ctcttttcca   1080

aaaatcttct tcgcacagct cccactgggt aaacattcgc cagacagtgt ccagtggccc   1140

tggatcctac ggcctcctgg tggcagggtc tgagtctttg gcctcgctgc tattttccca   1200

aagcctccag cagcggggag accctgggat ttgcgacagg acagcctggc tggggagtca   1260

aggctgccat ctctccttgc tttcattctg gttccccatc gatgtggcgt ggggaaagga   1320

gcaggtgact atgatgctgg cttggctgac actggaatgg atgcagtggc tgcatattaa   1380

tgctacggcg tgcacacaca tatgccaggt taaagttcag tagcaagttt ttacaacatg   1440

atttctgctg cttctgttgg acgggctctc gggcttacct acgtgtgcga agcaacactc   1500

cctaccgcag ctttcatgca caatttaact cacccccgcc ctgcctgcgt ggagcctcat   1560

ttttattttg taggagctcg aatcattatt tggatattaa taaaaacaaa tcttggctga   1620

tgctaaccat ctgatttcct tttttttttt ttccattttg ttttgttttg tttctgcaca   1680

cattttcttt agcttgaaat ggcgattgaa aacctccaaa aaagcgaagg aatcacatca   1740

cacaaaagcg gtttactcaa cagccatctc cagtggctgt tggataatta tgaaacagcg   1800

gaaggtgtga gtctccccag aagttctctt tacaaccact accttcggca ctgccaggag   1860

cacaagctag acccagtgaa cgccgcctcc ttcgggaaac tgatccgttc tgtgtttatg   1920

gggctgagaa cgcggcggct gggcaccagg tgggcaactg tagatgtggt gatgaacctc   1980

cagttccact acatcgagaa gctgtggctc tccttctgga actctaaggc ctcctccagc   2040

gacggcccca cctctcttcc tgccagtgac gaagaccccg agggcgccgt cctgcccaag   2100

gacaagctta tctccctgtg tcagtgcgac cccatcctca ggtggatgag gagctgcgac   2160

cacatcctct accaggcgct ggtggagatt ctcatccccg acgtgctgag gccggtcccc   2220

agtaccttga cacaggccat ccgtaacttt gccaagagct tggaaggctg gttgacaaat   2280

gccatgagtg acttcccaca acaggtcatc cagaccaagg tgggcgtcgt cagtgccttc   2340

gcccagacgc tgcggcgcta cacgtccctc aaccacctgg cgcaggcggc ccgggcggtg   2400

ctgcagaaca cgtcccagat caaccagatg ctcagcgacc tcaaccgcgt ggactttgcc   2460

aacgtgcagg agcaggcctc gtgggtgtgc cagtgcgagg agagtgtggt gcagcggctg   2520

gagcaggatt tcaagctgac cctgcagcag cagagctccc tggaccagtg ggccagctgg   2580

ctggacagtg tggtcaccca ggtcctgaag cagcatgccg gcagccccag cttccccaag   2640

gccgcccggc agttcttgct gaaatggtcc ttttacagct ccatggtgat ccgggacctg   2700

accctgcgca gcgctgccag cttcggctcc ttccacctca tccgcctgct ctacgacgag   2760

tacatgttct acctggtgga gcaccgcgtc gcggaggcca ccggagagac gccgatcgct   2820

gtgatgggag agttcaacga tctcgcctct ctgtcgctga cgctgctcga caaagatgac   2880

atgggcgatg agcagcgtgg cagcgaggcg ggcccagacg cccgcagcct gggtgagccc   2940

ctggtaaagc gggagcgcag tgaccccaac cactccctgc agggcatcta gcagccccgg   3000

ccggcgcctc ctcgaggttc caaaagatgc cgcctggtca ctctgggaac ctggatttca   3060

ccggctccac caaattagtg cctcttagat gatgtgatgt ttactttgac tcaagcgggg   3120

gctcccgggg tcagtgttca agaaggaaag cagttgttga agctacagaa gcccaggcca   3180

gggctcccac tggctgtagc tgtgctctgg gtccccaggt ccctgcgcag ccaccagggc   3240

cccaccagac catgggttcc ttattctgga caaaccctcc tctgctggaa ccctggactt   3300

tggccccagt ccctttaaga gctgaaaggg ctgtgctgag agcactggcc tctgcactca   3360

actggaacca attttcacca tgattttaaa aattaaaaaa acctggcaga gcccgactag   3420

aaagggacgg cctctcccct cctacctgcc accgctgggg aggcacagag ctcgccagcg   3480

tccctggagt cccctcagga atggaaagtg gagtgccctt gtctggtagc accatgtggg   3540

agggacccag ctgggcgcag cgccctgtgg ccttttagat ccagacctcc ctgccggatg   3600

ccccgaggcg ggaggccggc tgtgctgcag gaacccatct ccagatgcca aaggacttga   3660

ggggcagctg acaatcgctg tgtcccggca gatccgcagc tcgaaaaaga acaagccaca   3720

gaaacgggct cgctcgtgcc aggacacagc agtgtctttc aaaaaatcaa aaccagaagt   3780

tttatcagca gcaggaagga tgtgggactc tgtccaagtt caccgtcacc atcaagccac   3840

tggctgtgga aggagtttgt ccaacagggt cagtgtcaca gccacaactt cagaaagcag   3900

ccatcccgcg tgtcgtccaa acagcagtgc ctgcgtcccg ctccacggag tcttccagaa   3960

cacctccctc tgaactaatc ccggagcacc ccacccccag cgagtcccac ctggacctct   4020

tcaaagtcaa aactcttctc tcgggacaaa caaatattcg ggactttcga agccctgaac   4080

ttgagacacc aagtttgtct ccatggaaac acgtagccgc tgcagttgga cagctgcgtg   4140

ctggagttct gtccccaaac caactgcaga gaagaaagac gagcctcggc ccaggacgcg   4200

atttctaacg aaatgcaata gttttctctt tttggaaaaa tgtttatacc aatagttttg   4260

tgcgctaatt gttattagaa cgtttcttat gaatgtgtac attgcagtat attcagtccc   4320


<210>  3510
<211>  430
<212>  PRT
<213>  Homo sapiens

<400>  3510


Met Ala Ile Glu Asn Leu Gln Lys Ser Glu Gly Ile Thr Ser His Lys 
1               5                   10                  15      


Ser Gly Leu Leu Asn Ser His Leu Gln Trp Leu Leu Asp Asn Tyr Glu 
            20                  25                  30          


Thr Ala Glu Gly Val Ser Leu Pro Arg Ser Ser Leu Tyr Asn His Tyr 
        35                  40                  45              


Leu Arg His Cys Gln Glu His Lys Leu Asp Pro Val Asn Ala Ala Ser 
    50                  55                  60                  


Phe Gly Lys Leu Ile Arg Ser Val Phe Met Gly Leu Arg Thr Arg Arg 
65                  70                  75                  80  


Leu Gly Thr Arg Trp Ala Thr Val Asp Val Val Met Asn Leu Gln Phe 
                85                  90                  95      


His Tyr Ile Glu Lys Leu Trp Leu Ser Phe Trp Asn Ser Lys Ala Ser 
            100                 105                 110         


Ser Ser Asp Gly Pro Thr Ser Leu Pro Ala Ser Asp Glu Asp Pro Glu 
        115                 120                 125             


Gly Ala Val Leu Pro Lys Asp Lys Leu Ile Ser Leu Cys Gln Cys Asp 
    130                 135                 140                 


Pro Ile Leu Arg Trp Met Arg Ser Cys Asp His Ile Leu Tyr Gln Ala 
145                 150                 155                 160 


Leu Val Glu Ile Leu Ile Pro Asp Val Leu Arg Pro Val Pro Ser Thr 
                165                 170                 175     


Leu Thr Gln Ala Ile Arg Asn Phe Ala Lys Ser Leu Glu Gly Trp Leu 
            180                 185                 190         


Thr Asn Ala Met Ser Asp Phe Pro Gln Gln Val Ile Gln Thr Lys Val 
        195                 200                 205             


Gly Val Val Ser Ala Phe Ala Gln Thr Leu Arg Arg Tyr Thr Ser Leu 
    210                 215                 220                 


Asn His Leu Ala Gln Ala Ala Arg Ala Val Leu Gln Asn Thr Ser Gln 
225                 230                 235                 240 


Ile Asn Gln Met Leu Ser Asp Leu Asn Arg Val Asp Phe Ala Asn Val 
                245                 250                 255     


Gln Glu Gln Ala Ser Trp Val Cys Gln Cys Glu Glu Ser Val Val Gln 
            260                 265                 270         


Arg Leu Glu Gln Asp Phe Lys Leu Thr Leu Gln Gln Gln Ser Ser Leu 
        275                 280                 285             


Asp Gln Trp Ala Ser Trp Leu Asp Ser Val Val Thr Gln Val Leu Lys 
    290                 295                 300                 


Gln His Ala Gly Ser Pro Ser Phe Pro Lys Ala Ala Arg Gln Phe Leu 
305                 310                 315                 320 


Leu Lys Trp Ser Phe Tyr Ser Ser Met Val Ile Arg Asp Leu Thr Leu 
                325                 330                 335     


Arg Ser Ala Ala Ser Phe Gly Ser Phe His Leu Ile Arg Leu Leu Tyr 
            340                 345                 350         


Asp Glu Tyr Met Phe Tyr Leu Val Glu His Arg Val Ala Glu Ala Thr 
        355                 360                 365             


Gly Glu Thr Pro Ile Ala Val Met Gly Glu Phe Asn Asp Leu Ala Ser 
    370                 375                 380                 


Leu Ser Leu Thr Leu Leu Asp Lys Asp Asp Met Gly Asp Glu Gln Arg 
385                 390                 395                 400 


Gly Ser Glu Ala Gly Pro Asp Ala Arg Ser Leu Gly Glu Pro Leu Val 
                405                 410                 415     


Lys Arg Glu Arg Ser Asp Pro Asn His Ser Leu Gln Gly Ile 
            420                 425                 430 

<210>  3511
<211>  3606
<212>  DNA
<213>  Homo sapiens

<400>  3511
agacgggaac agcatggtgg atggtgtgca aatgactgat ttaaacattt aaaggaaact     60

gtaaatacaa gcagcttgta acagaaaaat tccaaagacc tgagcatgca gaattccgag    120

ggtggagcgg attcgccagc gtccgtggct ctgcgtccct cggcggcagc cccgcctgtg    180

ccagcctccc cgcagagggt gttggtccag gcagccagct ccaatcccaa aggggcccag    240

atgcagccga tctccctccc cagagttcag caggtacccc agcaggtgca gccggtgcag    300

cacgtgtatc ctgcccaggt gcagtacgtg gaagggggag acgccgtcta caccaatgga    360

gccatacgaa cagcctacac ctacaacccc gagcctcaga tgtacgcccc cagcagcacg    420

gcttcttact tcgaggcccc aggcggtgcc caggtgaccg tggcagcctc gtccccgcca    480

gcggtcccct cccacagcat ggtgggcatc accatggatg tcggggggag ccccatcgtc    540

tccagcgcgg gagcctatct catccacggg gggatggaca gcaccagaca ctccctggcc    600

cacacctccc gctcatcgcc cgccacgctt gaaatggcga ttgaaaacct ccaaaaaagc    660

gaaggaatca catcacacaa aagcggttta ctcaacagcc atctccagtg gctgttggat    720

aattatgaaa cagcggaagg tgtgagtctc cccagaagtt ctctttacaa ccactacctt    780

cggcactgcc aggagcacaa gctagaccca gtgaacgccg cctccttcgg gaaactgatc    840

cgttctgtgt ttatggggct gagaacgcgg cggctgggca ccaggggcaa ctcgaagtac    900

cattactatg ggattcgtct gaagccggac tcaccactga accggctgca ggaggacacg    960

cagtacatgg ccatgcggca gcagcccatg caccagaagc ccaggtaccg gccagcccag   1020

aagacggaca gcctcgggga cagcggctcc cacagcggcc tgcacagcac tccggaacag   1080

accatggccg tgcagagcca gcaccaccag cagtacatag atgtctccca cgtcttcccc   1140

gagttcccag cgcccgacct gggcagcttc ctgctgcagg acggcgtcac actgcacgac   1200

gtcaaggccc tgcagctggt gtacagacgg cactgcgagg caactgtaga tgtggtgatg   1260

aacctccagt tccactacat cgagaagctg tggctctcct tctggaactc taaggcctcc   1320

tccagcgacg gccccacctc tcttcctgcc agtgacgaag accccgaggg cgccgtcctg   1380

cccaaggaca agcttatctc cctgtgtcag tgcgacccca tcctcaggtg gatgaggagc   1440

tgcgaccaca tcctctacca ggcgctggtg gagattctca tccccgacgt gctgaggccg   1500

gtccccagta ccttgacaca ggccatccgt aactttgcca agagcttgga aggctggttg   1560

acaaatgcca tgagtgactt cccacaacag gtcatccaga ccaaggtggg cgtcgtcagt   1620

gccttcgccc agacgctgcg gcgctacacg tccctcaacc acctggcgca ggcggcccgg   1680

gcggtgctgc agaacacgtc ccagatcaac cagatgctca gcgacctcaa ccgcgtggac   1740

tttgccaacg tgcaggagca ggcctcgtgg gtgtgccagt gcgaggagag tgtggtgcag   1800

cggctggagc aggatttcaa gctgaccctg cagcagcaga gctccctgga ccagtgggcc   1860

agctggctgg acagtgtggt cacccaggtc ctgaagcagc atgccggcag ccccagcttc   1920

cccaaggccg cccggcagtt cttgctgaaa tggtcctttt acagctccat ggtgatccgg   1980

gacctgaccc tgcgcagcgc tgccagcttc ggctccttcc acctcatccg cctgctctac   2040

gacgagtaca tgttctacct ggtggagcac cgcgtcgcgg aggccaccgg agagacgccg   2100

atcgctgtga tgggagagtt caacgatctc gcctctctgt cgctgacgct gctcgacaaa   2160

gatgacatgg gcgatgagca gcgtggcagc gaggcgggcc cagacgcccg cagcctgggt   2220

gagcccctgg taaagcggga gcgcagtgac cccaaccact ccctgcaggg catctagcag   2280

ccccggccgg cgcctcctcg aggttccaaa agatgccgcc tggtcactct gggaacctgg   2340

atttcaccgg ctccaccaaa ttagtgcctc ttagatgatg tgatgtttac tttgactcaa   2400

gcgggggctc ccggggtcag tgttcaagaa ggaaagcagt tgttgaagct acagaagccc   2460

aggccagggc tcccactggc tgtagctgtg ctctgggtcc ccaggtccct gcgcagccac   2520

cagggcccca ccagaccatg ggttccttat tctggacaaa ccctcctctg ctggaaccct   2580

ggactttggc cccagtccct ttaagagctg aaagggctgt gctgagagca ctggcctctg   2640

cactcaactg gaaccaattt tcaccatgat tttaaaaatt aaaaaaacct ggcagagccc   2700

gactagaaag ggacggcctc tcccctccta cctgccaccg ctggggaggc acagagctcg   2760

ccagcgtccc tggagtcccc tcaggaatgg aaagtggagt gcccttgtct ggtagcacca   2820

tgtgggaggg acccagctgg gcgcagcgcc ctgtggcctt ttagatccag acctccctgc   2880

cggatgcccc gaggcgggag gccggctgtg ctgcaggaac ccatctccag atgccaaagg   2940

acttgagggg cagctgacaa tcgctgtgtc ccggcagatc cgcagctcga aaaagaacaa   3000

gccacagaaa cgggctcgct cgtgccagga cacagcagtg tctttcaaaa aatcaaaacc   3060

agaagtttta tcagcagcag gaaggatgtg ggactctgtc caagttcacc gtcaccatca   3120

agccactggc tgtggaagga gtttgtccaa cagggtcagt gtcacagcca caacttcaga   3180

aagcagccat cccgcgtgtc gtccaaacag cagtgcctgc gtcccgctcc acggagtctt   3240

ccagaacacc tccctctgaa ctaatcccgg agcaccccac ccccagcgag tcccacctgg   3300

acctcttcaa agtcaaaact cttctctcgg gacaaacaaa tattcgggac tttcgaagcc   3360

ctgaacttga gacaccaagt ttgtctccat ggaaacacgt agccgctgca gttggacagc   3420

tgcgtgctgg agttctgtcc ccaaaccaac tgcagagaag aaagacgagc ctcggcccag   3480

gacgcgattt ctaacgaaat gcaatagttt tctctttttg gaaaaatgtt tataccaata   3540

gttttgtgcg ctaattgtta ttagaacgtt tcttatgaat gtgtacattg cagtatattc   3600

agtccc                                                              3606


<210>  3512
<211>  723
<212>  PRT
<213>  Homo sapiens

<400>  3512


Met Gln Asn Ser Glu Gly Gly Ala Asp Ser Pro Ala Ser Val Ala Leu 
1               5                   10                  15      


Arg Pro Ser Ala Ala Ala Pro Pro Val Pro Ala Ser Pro Gln Arg Val 
            20                  25                  30          


Leu Val Gln Ala Ala Ser Ser Asn Pro Lys Gly Ala Gln Met Gln Pro 
        35                  40                  45              


Ile Ser Leu Pro Arg Val Gln Gln Val Pro Gln Gln Val Gln Pro Val 
    50                  55                  60                  


Gln His Val Tyr Pro Ala Gln Val Gln Tyr Val Glu Gly Gly Asp Ala 
65                  70                  75                  80  


Val Tyr Thr Asn Gly Ala Ile Arg Thr Ala Tyr Thr Tyr Asn Pro Glu 
                85                  90                  95      


Pro Gln Met Tyr Ala Pro Ser Ser Thr Ala Ser Tyr Phe Glu Ala Pro 
            100                 105                 110         


Gly Gly Ala Gln Val Thr Val Ala Ala Ser Ser Pro Pro Ala Val Pro 
        115                 120                 125             


Ser His Ser Met Val Gly Ile Thr Met Asp Val Gly Gly Ser Pro Ile 
    130                 135                 140                 


Val Ser Ser Ala Gly Ala Tyr Leu Ile His Gly Gly Met Asp Ser Thr 
145                 150                 155                 160 


Arg His Ser Leu Ala His Thr Ser Arg Ser Ser Pro Ala Thr Leu Glu 
                165                 170                 175     


Met Ala Ile Glu Asn Leu Gln Lys Ser Glu Gly Ile Thr Ser His Lys 
            180                 185                 190         


Ser Gly Leu Leu Asn Ser His Leu Gln Trp Leu Leu Asp Asn Tyr Glu 
        195                 200                 205             


Thr Ala Glu Gly Val Ser Leu Pro Arg Ser Ser Leu Tyr Asn His Tyr 
    210                 215                 220                 


Leu Arg His Cys Gln Glu His Lys Leu Asp Pro Val Asn Ala Ala Ser 
225                 230                 235                 240 


Phe Gly Lys Leu Ile Arg Ser Val Phe Met Gly Leu Arg Thr Arg Arg 
                245                 250                 255     


Leu Gly Thr Arg Gly Asn Ser Lys Tyr His Tyr Tyr Gly Ile Arg Leu 
            260                 265                 270         


Lys Pro Asp Ser Pro Leu Asn Arg Leu Gln Glu Asp Thr Gln Tyr Met 
        275                 280                 285             


Ala Met Arg Gln Gln Pro Met His Gln Lys Pro Arg Tyr Arg Pro Ala 
    290                 295                 300                 


Gln Lys Thr Asp Ser Leu Gly Asp Ser Gly Ser His Ser Gly Leu His 
305                 310                 315                 320 


Ser Thr Pro Glu Gln Thr Met Ala Val Gln Ser Gln His His Gln Gln 
                325                 330                 335     


Tyr Ile Asp Val Ser His Val Phe Pro Glu Phe Pro Ala Pro Asp Leu 
            340                 345                 350         


Gly Ser Phe Leu Leu Gln Asp Gly Val Thr Leu His Asp Val Lys Ala 
        355                 360                 365             


Leu Gln Leu Val Tyr Arg Arg His Cys Glu Ala Thr Val Asp Val Val 
    370                 375                 380                 


Met Asn Leu Gln Phe His Tyr Ile Glu Lys Leu Trp Leu Ser Phe Trp 
385                 390                 395                 400 


Asn Ser Lys Ala Ser Ser Ser Asp Gly Pro Thr Ser Leu Pro Ala Ser 
                405                 410                 415     


Asp Glu Asp Pro Glu Gly Ala Val Leu Pro Lys Asp Lys Leu Ile Ser 
            420                 425                 430         


Leu Cys Gln Cys Asp Pro Ile Leu Arg Trp Met Arg Ser Cys Asp His 
        435                 440                 445             


Ile Leu Tyr Gln Ala Leu Val Glu Ile Leu Ile Pro Asp Val Leu Arg 
    450                 455                 460                 


Pro Val Pro Ser Thr Leu Thr Gln Ala Ile Arg Asn Phe Ala Lys Ser 
465                 470                 475                 480 


Leu Glu Gly Trp Leu Thr Asn Ala Met Ser Asp Phe Pro Gln Gln Val 
                485                 490                 495     


Ile Gln Thr Lys Val Gly Val Val Ser Ala Phe Ala Gln Thr Leu Arg 
            500                 505                 510         


Arg Tyr Thr Ser Leu Asn His Leu Ala Gln Ala Ala Arg Ala Val Leu 
        515                 520                 525             


Gln Asn Thr Ser Gln Ile Asn Gln Met Leu Ser Asp Leu Asn Arg Val 
    530                 535                 540                 


Asp Phe Ala Asn Val Gln Glu Gln Ala Ser Trp Val Cys Gln Cys Glu 
545                 550                 555                 560 


Glu Ser Val Val Gln Arg Leu Glu Gln Asp Phe Lys Leu Thr Leu Gln 
                565                 570                 575     


Gln Gln Ser Ser Leu Asp Gln Trp Ala Ser Trp Leu Asp Ser Val Val 
            580                 585                 590         


Thr Gln Val Leu Lys Gln His Ala Gly Ser Pro Ser Phe Pro Lys Ala 
        595                 600                 605             


Ala Arg Gln Phe Leu Leu Lys Trp Ser Phe Tyr Ser Ser Met Val Ile 
    610                 615                 620                 


Arg Asp Leu Thr Leu Arg Ser Ala Ala Ser Phe Gly Ser Phe His Leu 
625                 630                 635                 640 


Ile Arg Leu Leu Tyr Asp Glu Tyr Met Phe Tyr Leu Val Glu His Arg 
                645                 650                 655     


Val Ala Glu Ala Thr Gly Glu Thr Pro Ile Ala Val Met Gly Glu Phe 
            660                 665                 670         


Asn Asp Leu Ala Ser Leu Ser Leu Thr Leu Leu Asp Lys Asp Asp Met 
        675                 680                 685             


Gly Asp Glu Gln Arg Gly Ser Glu Ala Gly Pro Asp Ala Arg Ser Leu 
    690                 695                 700                 


Gly Glu Pro Leu Val Lys Arg Glu Arg Ser Asp Pro Asn His Ser Leu 
705                 710                 715                 720 


Gln Gly Ile 
            

<210>  3513
<211>  3747
<212>  DNA
<213>  Homo sapiens

<400>  3513
aaggtggggc gcggagcctg gtaaccgttg ccggtaacaa cgccccgccc cgtcgggcgg     60

gcgggctgcg cgaggctggc tggcggcggg agccggagga ggagcggccg ccgccgccac    120

cgccgccgcc atagagactg tagccgtgga gactgttact taccaacggg gaccaacacg    180

cagcagccgc tgccgccgcc gcgggagccg ctgcccgaac tcccggcccg aactccagac    240

ctgagcatgc agaattccga gggtggagcg gattcgccag cgtccgtggc tctgcgtccc    300

tcggcggcag ccccgcctgt gccagcctcc ccgcagaggg tgttggtcca ggcagccagc    360

tccaatccca aaggggccca gatgcagccg atctccctcc ccagagttca gcaggtaccc    420

cagcaggtgc agccggtgca gcacgtgtat cctgcccagg tgcagtacgt ggaaggggga    480

gacgccgtct acaccaatgg agccatacga acagcctaca cctacaaccc cgagcctcag    540

atgtacgccc ccagcagcac ggcttcttac ttcgaggccc caggcggtgc ccaggtgacc    600

gtggcagcct cgtccccgcc agcggtcccc tcccacagca tggtgggcat caccatggat    660

gtcgggggga gccccatcgt ctccagcgcg ggagcctatc tcatccacgg ggggatggac    720

agcaccagac actccctggc ccacacctcc cgctcatcgc ccgccacgct tgaaatggcg    780

attgaaaacc tccaaaaaag cgaaggaatc acatcacaca aaagcggttt actcaacagc    840

catctccagt ggctgttgga taattatgaa acagcggaag gtgtgagtct ccccagaagt    900

tctctttaca accactacct tcggcactgc caggagcaca agctagaccc agtgaacgcc    960

gcctccttcg ggaaactgat ccgttctgtg tttatggggc tgagaacgcg gcggctgggc   1020

accaggggca actcgaagta ccattactat gggattcgtc tgaagccgga ctcaccactg   1080

aaccggctgc aggaggacac gcagtacatg gccatgcggc agcagcccat gcaccagaag   1140

cccaggtacc ggccagccca gaagacggac agcctcgggg acagcggctc ccacagcggc   1200

ctgcacagca ctccggaaca gaccatggcc gtgcagagcc agcaccacca gcagtacata   1260

gatgtctccc acgtcttccc cgagttccca gcgcccgacc tgggcagctt cctgctgcag   1320

gacggcgtca cactgcacga cgtcaaggcc ctgcagctgg tgtacagacg gcactgcgag   1380

gcaactgtag atgtggtgat gaacctccag ttccactaca tcgagaagct gtggctctcc   1440

ttctggaact ctaaggcctc ctccagcgac ggccccacct ctcttcctgc cagtgacgaa   1500

gaccccgagg gcgccgtcct gcccaaggac aagcttatct ccctgtgtca gtgcgacccc   1560

atcctcaggt ggatgaggag ctgcgaccac atcctctacc aggcgctggt ggagattctc   1620

atccccgacg tgctgaggcc ggtccccagt accttgacac aggccatccg taactttgcc   1680

aagagcttgg aaggctggtt gacaaatgcc atgagtgact tcccacaaca ggtcatccag   1740

accaaggtgg gcgtcgtcag tgccttcgcc cagacgctgc ggcgctacac gtccctcaac   1800

cacctggcgc aggcggcccg ggcggtgctg cagaacacgt cccagatcaa ccagatgctc   1860

agcgacctca accgcgtgga ctttgccaac gtgcaggagc aggcctcgtg ggtgtgccag   1920

tgcgaggaga gtgtggtgca gcggctggag caggatttca agctgaccct gcagcagcag   1980

agctccctgg accagtgggc cagctggctg gacagtgtgg tcacccaggt cctgaagcag   2040

catgccggca gccccagctt ccccaaggcc gcccggcagt tcttgctgaa atggtccttt   2100

tacagctcca tggtgatccg ggacctgacc ctgcgcagcg ctgccagctt cggctccttc   2160

cacctcatcc gcctgctcta cgacgagtac atgttctacc tggtggagca ccgcgtcgcg   2220

gaggccaccg gagagacgcc gatcgctgtg atgggagagt tcaacgatct cgcctctctg   2280

tcgctgacgc tgctcgacaa agatgacatg ggcgatgagc agcgtggcag cgaggcgggc   2340

ccagacgccc gcagcctggg tgagcccctg gtaaagcggg agcgcagtga ccccaaccac   2400

tccctgcagg gcatctagca gccccggccg gcgcctcctc gaggttccaa aagatgccgc   2460

ctggtcactc tgggaacctg gatttcaccg gctccaccaa attagtgcct cttagatgat   2520

gtgatgttta ctttgactca agcgggggct cccggggtca gtgttcaaga aggaaagcag   2580

ttgttgaagc tacagaagcc caggccaggg ctcccactgg ctgtagctgt gctctgggtc   2640

cccaggtccc tgcgcagcca ccagggcccc accagaccat gggttcctta ttctggacaa   2700

accctcctct gctggaaccc tggactttgg ccccagtccc tttaagagct gaaagggctg   2760

tgctgagagc actggcctct gcactcaact ggaaccaatt ttcaccatga ttttaaaaat   2820

taaaaaaacc tggcagagcc cgactagaaa gggacggcct ctcccctcct acctgccacc   2880

gctggggagg cacagagctc gccagcgtcc ctggagtccc ctcaggaatg gaaagtggag   2940

tgcccttgtc tggtagcacc atgtgggagg gacccagctg ggcgcagcgc cctgtggcct   3000

tttagatcca gacctccctg ccggatgccc cgaggcggga ggccggctgt gctgcaggaa   3060

cccatctcca gatgccaaag gacttgaggg gcagctgaca atcgctgtgt cccggcagat   3120

ccgcagctcg aaaaagaaca agccacagaa acgggctcgc tcgtgccagg acacagcagt   3180

gtctttcaaa aaatcaaaac cagaagtttt atcagcagca ggaaggatgt gggactctgt   3240

ccaagttcac cgtcaccatc aagccactgg ctgtggaagg agtttgtcca acagggtcag   3300

tgtcacagcc acaacttcag aaagcagcca tcccgcgtgt cgtccaaaca gcagtgcctg   3360

cgtcccgctc cacggagtct tccagaacac ctccctctga actaatcccg gagcacccca   3420

cccccagcga gtcccacctg gacctcttca aagtcaaaac tcttctctcg ggacaaacaa   3480

atattcggga ctttcgaagc cctgaacttg agacaccaag tttgtctcca tggaaacacg   3540

tagccgctgc agttggacag ctgcgtgctg gagttctgtc cccaaaccaa ctgcagagaa   3600

gaaagacgag cctcggccca ggacgcgatt tctaacgaaa tgcaatagtt ttctcttttt   3660

ggaaaaatgt ttataccaat agttttgtgc gctaattgtt attagaacgt ttcttatgaa   3720

tgtgtacatt gcagtatatt cagtccc                                       3747


<210>  3514
<211>  723
<212>  PRT
<213>  Homo sapiens

<400>  3514


Met Gln Asn Ser Glu Gly Gly Ala Asp Ser Pro Ala Ser Val Ala Leu 
1               5                   10                  15      


Arg Pro Ser Ala Ala Ala Pro Pro Val Pro Ala Ser Pro Gln Arg Val 
            20                  25                  30          


Leu Val Gln Ala Ala Ser Ser Asn Pro Lys Gly Ala Gln Met Gln Pro 
        35                  40                  45              


Ile Ser Leu Pro Arg Val Gln Gln Val Pro Gln Gln Val Gln Pro Val 
    50                  55                  60                  


Gln His Val Tyr Pro Ala Gln Val Gln Tyr Val Glu Gly Gly Asp Ala 
65                  70                  75                  80  


Val Tyr Thr Asn Gly Ala Ile Arg Thr Ala Tyr Thr Tyr Asn Pro Glu 
                85                  90                  95      


Pro Gln Met Tyr Ala Pro Ser Ser Thr Ala Ser Tyr Phe Glu Ala Pro 
            100                 105                 110         


Gly Gly Ala Gln Val Thr Val Ala Ala Ser Ser Pro Pro Ala Val Pro 
        115                 120                 125             


Ser His Ser Met Val Gly Ile Thr Met Asp Val Gly Gly Ser Pro Ile 
    130                 135                 140                 


Val Ser Ser Ala Gly Ala Tyr Leu Ile His Gly Gly Met Asp Ser Thr 
145                 150                 155                 160 


Arg His Ser Leu Ala His Thr Ser Arg Ser Ser Pro Ala Thr Leu Glu 
                165                 170                 175     


Met Ala Ile Glu Asn Leu Gln Lys Ser Glu Gly Ile Thr Ser His Lys 
            180                 185                 190         


Ser Gly Leu Leu Asn Ser His Leu Gln Trp Leu Leu Asp Asn Tyr Glu 
        195                 200                 205             


Thr Ala Glu Gly Val Ser Leu Pro Arg Ser Ser Leu Tyr Asn His Tyr 
    210                 215                 220                 


Leu Arg His Cys Gln Glu His Lys Leu Asp Pro Val Asn Ala Ala Ser 
225                 230                 235                 240 


Phe Gly Lys Leu Ile Arg Ser Val Phe Met Gly Leu Arg Thr Arg Arg 
                245                 250                 255     


Leu Gly Thr Arg Gly Asn Ser Lys Tyr His Tyr Tyr Gly Ile Arg Leu 
            260                 265                 270         


Lys Pro Asp Ser Pro Leu Asn Arg Leu Gln Glu Asp Thr Gln Tyr Met 
        275                 280                 285             


Ala Met Arg Gln Gln Pro Met His Gln Lys Pro Arg Tyr Arg Pro Ala 
    290                 295                 300                 


Gln Lys Thr Asp Ser Leu Gly Asp Ser Gly Ser His Ser Gly Leu His 
305                 310                 315                 320 


Ser Thr Pro Glu Gln Thr Met Ala Val Gln Ser Gln His His Gln Gln 
                325                 330                 335     


Tyr Ile Asp Val Ser His Val Phe Pro Glu Phe Pro Ala Pro Asp Leu 
            340                 345                 350         


Gly Ser Phe Leu Leu Gln Asp Gly Val Thr Leu His Asp Val Lys Ala 
        355                 360                 365             


Leu Gln Leu Val Tyr Arg Arg His Cys Glu Ala Thr Val Asp Val Val 
    370                 375                 380                 


Met Asn Leu Gln Phe His Tyr Ile Glu Lys Leu Trp Leu Ser Phe Trp 
385                 390                 395                 400 


Asn Ser Lys Ala Ser Ser Ser Asp Gly Pro Thr Ser Leu Pro Ala Ser 
                405                 410                 415     


Asp Glu Asp Pro Glu Gly Ala Val Leu Pro Lys Asp Lys Leu Ile Ser 
            420                 425                 430         


Leu Cys Gln Cys Asp Pro Ile Leu Arg Trp Met Arg Ser Cys Asp His 
        435                 440                 445             


Ile Leu Tyr Gln Ala Leu Val Glu Ile Leu Ile Pro Asp Val Leu Arg 
    450                 455                 460                 


Pro Val Pro Ser Thr Leu Thr Gln Ala Ile Arg Asn Phe Ala Lys Ser 
465                 470                 475                 480 


Leu Glu Gly Trp Leu Thr Asn Ala Met Ser Asp Phe Pro Gln Gln Val 
                485                 490                 495     


Ile Gln Thr Lys Val Gly Val Val Ser Ala Phe Ala Gln Thr Leu Arg 
            500                 505                 510         


Arg Tyr Thr Ser Leu Asn His Leu Ala Gln Ala Ala Arg Ala Val Leu 
        515                 520                 525             


Gln Asn Thr Ser Gln Ile Asn Gln Met Leu Ser Asp Leu Asn Arg Val 
    530                 535                 540                 


Asp Phe Ala Asn Val Gln Glu Gln Ala Ser Trp Val Cys Gln Cys Glu 
545                 550                 555                 560 


Glu Ser Val Val Gln Arg Leu Glu Gln Asp Phe Lys Leu Thr Leu Gln 
                565                 570                 575     


Gln Gln Ser Ser Leu Asp Gln Trp Ala Ser Trp Leu Asp Ser Val Val 
            580                 585                 590         


Thr Gln Val Leu Lys Gln His Ala Gly Ser Pro Ser Phe Pro Lys Ala 
        595                 600                 605             


Ala Arg Gln Phe Leu Leu Lys Trp Ser Phe Tyr Ser Ser Met Val Ile 
    610                 615                 620                 


Arg Asp Leu Thr Leu Arg Ser Ala Ala Ser Phe Gly Ser Phe His Leu 
625                 630                 635                 640 


Ile Arg Leu Leu Tyr Asp Glu Tyr Met Phe Tyr Leu Val Glu His Arg 
                645                 650                 655     


Val Ala Glu Ala Thr Gly Glu Thr Pro Ile Ala Val Met Gly Glu Phe 
            660                 665                 670         


Asn Asp Leu Ala Ser Leu Ser Leu Thr Leu Leu Asp Lys Asp Asp Met 
        675                 680                 685             


Gly Asp Glu Gln Arg Gly Ser Glu Ala Gly Pro Asp Ala Arg Ser Leu 
    690                 695                 700                 


Gly Glu Pro Leu Val Lys Arg Glu Arg Ser Asp Pro Asn His Ser Leu 
705                 710                 715                 720 


Gln Gly Ile 
            

<210>  3515
<211>  1402
<212>  DNA
<213>  Homo sapiens

<400>  3515
ttgcgacagg acagcctggc tggggagtca aggctgccat ctctccttgc tttcattctg     60

gttccccatc gatgtggcgt ggggaaagga gcaggtgact atgatgctgg cttggctgac    120

actggaatgg atgcagtggc tgcatattaa tgctacggcg tgcacacaca tatgccaggt    180

taaagttcag tagcaagttt ttacaacatg atttctgctg cttctgttgg acgggctctc    240

gggcttacct acgtgtgcga agcaacactc cctaccgcag ctttcatgca caatttaact    300

cacccccgcc ctgcctgcgt ggagcctcat ttttattttg taggagctcg aatcattatt    360

tggatattaa taaaaacaaa tcttggctga tgctaaccat ctgatttcct tttttttttt    420

ttccattttg ttttgttttg tttctgcaca cattttcttt agcttgaaat ggcgattgaa    480

aacctccaaa aaagcgaagg aatcacatca cacaaaagcg gtttactcaa cagccatctc    540

cagtggctgt tggataatta tgaaacagcg gaaggtgtga gtctccccag aagttctctt    600

tacaaccact accttcggca ctgccaggag cacaagctag acccagtgaa cgccgcctcc    660

ttcgggaaac tgatccgttc tgtgtttatg gggctgagaa cgcggcggct gggcaccagg    720

ggcaactcga agtaccatta ctatgggatt cgtctgaagc cggactcacc actgaaccgg    780

ctgcaggagg acacgcagta catggccatg cggcagcagc ccatgcacca gaagcccagg    840

taccggccag cccagaagac ggacagcctc ggggacagcg gctcccacag cggcctgcac    900

agcactccgg aacagaccat ggccgtgcag agccagcacc accagcagta catagatgtc    960

tcccacgtct tccccgagtt cccagcgccc gacctgggca gcttcctgct gcaggacggc   1020

gtcacactgc acgacgtcaa ggccctgcag ctggtgtaca gacggcactg cgaggtgacc   1080

gccccagccc aggcaggcag ctcctgcgtg tccctcccgg gaaccgccag cgctcaggcc   1140

aggcgtcccc gggtgacgct gaggagctgg agccccgagc cccccaacaa gcatcctctc   1200

tgaagcagca gcccctccgc atccatgtcc atcgcctgct cctctcctct ctgtggcctc   1260

ccttgggatt ccagggcacc ccgctgtagc ccggatcacg gctgctcact tgacgtgtgc   1320

tgagtgcacg tgatgggcgc acgcacccgt ctgtctcacc ggtcccttca ttcctaggca   1380

actgtagatg tggtgatgaa cc                                            1402


<210>  3516
<211>  244
<212>  PRT
<213>  Homo sapiens

<400>  3516


Met Ala Ile Glu Asn Leu Gln Lys Ser Glu Gly Ile Thr Ser His Lys 
1               5                   10                  15      


Ser Gly Leu Leu Asn Ser His Leu Gln Trp Leu Leu Asp Asn Tyr Glu 
            20                  25                  30          


Thr Ala Glu Gly Val Ser Leu Pro Arg Ser Ser Leu Tyr Asn His Tyr 
        35                  40                  45              


Leu Arg His Cys Gln Glu His Lys Leu Asp Pro Val Asn Ala Ala Ser 
    50                  55                  60                  


Phe Gly Lys Leu Ile Arg Ser Val Phe Met Gly Leu Arg Thr Arg Arg 
65                  70                  75                  80  


Leu Gly Thr Arg Gly Asn Ser Lys Tyr His Tyr Tyr Gly Ile Arg Leu 
                85                  90                  95      


Lys Pro Asp Ser Pro Leu Asn Arg Leu Gln Glu Asp Thr Gln Tyr Met 
            100                 105                 110         


Ala Met Arg Gln Gln Pro Met His Gln Lys Pro Arg Tyr Arg Pro Ala 
        115                 120                 125             


Gln Lys Thr Asp Ser Leu Gly Asp Ser Gly Ser His Ser Gly Leu His 
    130                 135                 140                 


Ser Thr Pro Glu Gln Thr Met Ala Val Gln Ser Gln His His Gln Gln 
145                 150                 155                 160 


Tyr Ile Asp Val Ser His Val Phe Pro Glu Phe Pro Ala Pro Asp Leu 
                165                 170                 175     


Gly Ser Phe Leu Leu Gln Asp Gly Val Thr Leu His Asp Val Lys Ala 
            180                 185                 190         


Leu Gln Leu Val Tyr Arg Arg His Cys Glu Val Thr Ala Pro Ala Gln 
        195                 200                 205             


Ala Gly Ser Ser Cys Val Ser Leu Pro Gly Thr Ala Ser Ala Gln Ala 
    210                 215                 220                 


Arg Arg Pro Arg Val Thr Leu Arg Ser Trp Ser Pro Glu Pro Pro Asn 
225                 230                 235                 240 


Lys His Pro Leu 
                

<210>  3517
<211>  1330
<212>  DNA
<213>  Homo sapiens

<400>  3517
gattctggga aatgtcgatc ggctgtgggc ggcgcactgg gtccgccccg ctgtagcctc     60

aggcctgacg gcgactccca ggctccggga cgattctggg cagtgtcgtc cccagaggtc    120

ggcggccgtt gcccgctcac cagcgacgcg gggcgcctgc ggggacggtg aggccctgct    180

gaggactccg gccagtatga gtcccggggg cggcggcggg gctcaggccc tgggtctgcc    240

ccgcggtgtg accccggccg gtgccttggt tttcctggcc ttcatgtcct cctatgtaaa    300

cgcggggtga tgacggcgcc gacctcttgg cgctgttgtg agagtgaagt gggcgcgtgg    360

ttagacgcca gccacagttg tctttgggtt atgtcgtcat gaagccggcg ctctacagtt    420

gtgtaacctt gaacaaatgg gttcagtatc ttggaatttc agttttgtca tcgtttaaaa    480

aatagatctg gaaaaatgtg aacgcacacc gtgcatagtg gtgaagactg aacgagctga    540

taaagttttt accattgttt tatgaggatt ttatttacag agtaattgat tttcctcgca    600

ggtggcacct ggtaaatggt tagcccttgc ggagaaacac cctgttagtt cccagggaga    660

gattggcgcc ctggagagtg attaccagtg tgcctttcca ttatggtgtg tcacaggtgc    720

cgcaagataa gcctgatttt tcatgactgc tttttcctgc ccttctgtgc cctcaggaca    780

ctgcccatct ctaagataag agcctggaaa gaggactctg ttggctgttg gaaattgcag    840

agtaatgcct caggtgacat ttaatgatgt ggctatagac ttcactcatg aagagtgggg    900

atggctcagt tctgctcaga gggacttata caaggatgtg atggtccaga attatgagaa    960

cctggtctct gtagcaggtc tttctgtaac taagccatat gtgatcacgt tattggagga   1020

tggaaaagag ccctggatga tggagaaaaa actgtcaaaa ggtatgattc cagattggga   1080

atcaagatgg gaaaacaagg aattatcaac aaagaaggat aattatgatg aagattcacc   1140

ccaaacagta ataatagaaa aagttgtaaa acaaagttat gaattttcaa attctaagaa   1200

gaatttggaa tatatagaga agttggaagg gaagcatgga agtcaggtag accatttcag   1260

accagcaatt ctcacctcta gagaaagccc cactgcagac agtgtttaca aatacaatat   1320

atttagaagc                                                          1330


<210>  3518
<211>  161
<212>  PRT
<213>  Homo sapiens

<400>  3518


Met Pro Gln Val Thr Phe Asn Asp Val Ala Ile Asp Phe Thr His Glu 
1               5                   10                  15      


Glu Trp Gly Trp Leu Ser Ser Ala Gln Arg Asp Leu Tyr Lys Asp Val 
            20                  25                  30          


Met Val Gln Asn Tyr Glu Asn Leu Val Ser Val Ala Gly Leu Ser Val 
        35                  40                  45              


Thr Lys Pro Tyr Val Ile Thr Leu Leu Glu Asp Gly Lys Glu Pro Trp 
    50                  55                  60                  


Met Met Glu Lys Lys Leu Ser Lys Gly Met Ile Pro Asp Trp Glu Ser 
65                  70                  75                  80  


Arg Trp Glu Asn Lys Glu Leu Ser Thr Lys Lys Asp Asn Tyr Asp Glu 
                85                  90                  95      


Asp Ser Pro Gln Thr Val Ile Ile Glu Lys Val Val Lys Gln Ser Tyr 
            100                 105                 110         


Glu Phe Ser Asn Ser Lys Lys Asn Leu Glu Tyr Ile Glu Lys Leu Glu 
        115                 120                 125             


Gly Lys His Gly Ser Gln Val Asp His Phe Arg Pro Ala Ile Leu Thr 
    130                 135                 140                 


Ser Arg Glu Ser Pro Thr Ala Asp Ser Val Tyr Lys Tyr Asn Ile Phe 
145                 150                 155                 160 


Arg 
    

<210>  3519
<211>  3355
<212>  DNA
<213>  Homo sapiens

<400>  3519
gattctggga aatgtcgatc ggctgtgggc ggcgcactgg gtccgccccg ctgtagcctc     60

aggcctgacg gcgactccca ggctccggga cgattctggg cagtgtcgtc cccagaggtc    120

ggcggccgtt gcccgctcac cagcgacgcg gggcgcctgc ggggacggtg aggccctgct    180

gaggactccg gccagtatga gtcccggggg cggcggcggg gctcaggccc tgggtctgcc    240

ccgcggtgtg accccggccg gtgccttggt tttcctggcc ttcatgtcct cctatgtaaa    300

cgcggggtga tgacggcgcc gacctcttgg cgctgttgtg agagtgaagt gggcgcgtgg    360

ttagacgcca gccacagttg tctttgggtt atgtcgtcat gaagccggcg ctctacagtt    420

gtgtaacctt gaacaaatgg gttcagtatc ttggaatttc agttttgtca tcgtttaaaa    480

aatagatctg gaaaaatgtg aacgcacacc gtgcatagtg gtgaagactg aacgagctga    540

taaagttttt accattgttt tatgaggatt ttatttacag agtaattgat tttcctcgca    600

ggtggcacct ggtaaatggt tagcccttgc ggagaaacac cctgttagtt cccagggaga    660

gattggcgcc ctggagagtg attaccagtg tgcctttcca ttatggtgtg tcacaggtgc    720

cgcaagataa gcctgatttt tcatgactgc tttttcctgc ccttctgtgc cctcaggaca    780

ctgcccatct ctaagataag agcctggaaa gaggactctg ttggctgttg gaaattgcag    840

agtaatgcct caggtgacat ttaatgatgt ggctatagac ttcactcatg aagagtgggg    900

atggctcagt tctgctcaga gggacttata caaggatgtg atggtccaga attatgagaa    960

cctggtctct gtagcaggtc tttctgtaac taagccatat gtgatcacgt tattggagga   1020

tggaaaagag ccctggatga tggagaaaaa actgtcaaaa ggtatgattc cagattggga   1080

atcaagatgg gaaaacaagg aattatcaac aaagaaggat aattatgatg aagattcacc   1140

ccaaacagta ataatagaaa aagttgtaaa acaaagttat gaattttcaa attctaagaa   1200

gaatttggaa tatatagaga agttggaagg gaagcatgga agtcaggtag accatttcag   1260

accagcaatt ctcacctcta gagaaagccc cactgcagac agtgtttaca aatacaatat   1320

atttagaagc acctttcatt caaagtctac tctttctgaa ccacaaaaaa tttctgctga   1380

agggaattca cacaaatatg atatattaaa gaagaactta ccaaaaaagt cagttataaa   1440

aaatgagaaa gtcaatggtg gaaagaaact tttgaattct aataaaagtg gggcagcctt   1500

cagccagggc aaatctctta cccttcccca gacttgtaat agagagaaaa tctatacatg   1560

cagtgaatgt gggaaagcct ttggcaaaca gtcaatcctc aatcgccact ggagaattca   1620

tacaggagag aagccctatg aatgtcgtga atgtgggaag acttttagcc atggctcatc   1680

ccttacacga catctgataa gccatagtgg agagaaacct tacaaatgta ttgaatgtgg   1740

gaaggccttt agccatgtct catcacttac taaccatcag agcactcaca ctggagagaa   1800

accatatgaa tgtatgaact gtggaaagtc ttttagtcgt gtgtcccatc ttattgaaca   1860

tctaagaatt catactcaag aaaaactcta tgagtgtcgt atatgtggaa aggccttcat   1920

tcataggtca tctctcattc accatcagaa aatccatact ggagagaagc cttatgaatg   1980

tagagaatgt gggaaagctt tctgctgtag ctcacacctt actcgacatc aaagaattca   2040

cactatggag aaacaatatg aatgcaacaa atgtctgaaa gtctttagta gcctctcatt   2100

tcttgttcag catcagagta ttcatactga agaaaaaccc tttgaatgtc agaaatgcag   2160

gaaatccttc aaccagcttg aatcactgaa tatgcatttg agaaatcaca ttagattgaa   2220

accctacgaa tgcagtatat gtgggaaagc ctttagtcat aggtcatccc tgcttcaaca   2280

tcacagaatt catactggag agaaacctta tgaatgtatt aaatgtggga agaccttcag   2340

ctgtagttca aaccttaccg tacatcagag aattcacact ggagaaaagc catataaatg   2400

taatgagtgt gggaaagctt ttagcaaagg ctcaaatctt actgcccatc aaagagtaca   2460

taatggagag aaacccaata gtgtggtaag tgtggaaaag cctttagact atatgaatca   2520

ctatacatgt gagaaatctt acagaagaga aactgtatga agcagtggtt atcatggtaa   2580

atttcctaga ttctccctta tttaacatta gaaaaattta tactggggaa agtcttatga   2640

atgtggtgaa tataggaaga ccttttagca aagatgcagg ccagtttgtt tattagactt   2700

tatactgtag agaaatcata tgaagaccat aaatgtggga aagcctttgt cagtattaat   2760

cccttaattg acataagtat actcacacta ggataaaacc ctgtacatgt agcaaatgtg   2820

ggaaagacta cagacaatag gaatctttta caaactccta caggagagaa gctgtatgaa   2880

tgtagaaaat ttagaaattg agggaagtct tcagttccaa gtatatccct tattctacag   2940

cagagaactc aaaatggaga gaaatctcat ttaagagatg tagcaaagtg ttcactaaga   3000

gtgtttatct tggtacacat cagaagatta atggtagaac aacctgaagg atttaggagt   3060

tatgtgtaaa tctttgcagt catgctattt gtaaactgga ttctacagga gagcaaataa   3120

acattataat aaaatatgca tttcttagag cagtagcttg cagtttcagt tgagttctac   3180

ttagaaattc tttttagcta gtgggcatgt gaagatattt agtcacccag aggagccagt   3240

aagtgttata atattgaaaa ttaaagctgc aaaagaaata aagtgatgtt aataaaagtt   3300

ttggcatcta ataaaatcat tttgtatatc acaaactctt tcactgtgac tattt        3355


<210>  3520
<211>  571
<212>  PRT
<213>  Homo sapiens

<400>  3520


Met Pro Gln Val Thr Phe Asn Asp Val Ala Ile Asp Phe Thr His Glu 
1               5                   10                  15      


Glu Trp Gly Trp Leu Ser Ser Ala Gln Arg Asp Leu Tyr Lys Asp Val 
            20                  25                  30          


Met Val Gln Asn Tyr Glu Asn Leu Val Ser Val Ala Gly Leu Ser Val 
        35                  40                  45              


Thr Lys Pro Tyr Val Ile Thr Leu Leu Glu Asp Gly Lys Glu Pro Trp 
    50                  55                  60                  


Met Met Glu Lys Lys Leu Ser Lys Gly Met Ile Pro Asp Trp Glu Ser 
65                  70                  75                  80  


Arg Trp Glu Asn Lys Glu Leu Ser Thr Lys Lys Asp Asn Tyr Asp Glu 
                85                  90                  95      


Asp Ser Pro Gln Thr Val Ile Ile Glu Lys Val Val Lys Gln Ser Tyr 
            100                 105                 110         


Glu Phe Ser Asn Ser Lys Lys Asn Leu Glu Tyr Ile Glu Lys Leu Glu 
        115                 120                 125             


Gly Lys His Gly Ser Gln Val Asp His Phe Arg Pro Ala Ile Leu Thr 
    130                 135                 140                 


Ser Arg Glu Ser Pro Thr Ala Asp Ser Val Tyr Lys Tyr Asn Ile Phe 
145                 150                 155                 160 


Arg Ser Thr Phe His Ser Lys Ser Thr Leu Ser Glu Pro Gln Lys Ile 
                165                 170                 175     


Ser Ala Glu Gly Asn Ser His Lys Tyr Asp Ile Leu Lys Lys Asn Leu 
            180                 185                 190         


Pro Lys Lys Ser Val Ile Lys Asn Glu Lys Val Asn Gly Gly Lys Lys 
        195                 200                 205             


Leu Leu Asn Ser Asn Lys Ser Gly Ala Ala Phe Ser Gln Gly Lys Ser 
    210                 215                 220                 


Leu Thr Leu Pro Gln Thr Cys Asn Arg Glu Lys Ile Tyr Thr Cys Ser 
225                 230                 235                 240 


Glu Cys Gly Lys Ala Phe Gly Lys Gln Ser Ile Leu Asn Arg His Trp 
                245                 250                 255     


Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Arg Glu Cys Gly Lys 
            260                 265                 270         


Thr Phe Ser His Gly Ser Ser Leu Thr Arg His Leu Ile Ser His Ser 
        275                 280                 285             


Gly Glu Lys Pro Tyr Lys Cys Ile Glu Cys Gly Lys Ala Phe Ser His 
    290                 295                 300                 


Val Ser Ser Leu Thr Asn His Gln Ser Thr His Thr Gly Glu Lys Pro 
305                 310                 315                 320 


Tyr Glu Cys Met Asn Cys Gly Lys Ser Phe Ser Arg Val Ser His Leu 
                325                 330                 335     


Ile Glu His Leu Arg Ile His Thr Gln Glu Lys Leu Tyr Glu Cys Arg 
            340                 345                 350         


Ile Cys Gly Lys Ala Phe Ile His Arg Ser Ser Leu Ile His His Gln 
        355                 360                 365             


Lys Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Arg Glu Cys Gly Lys 
    370                 375                 380                 


Ala Phe Cys Cys Ser Ser His Leu Thr Arg His Gln Arg Ile His Thr 
385                 390                 395                 400 


Met Glu Lys Gln Tyr Glu Cys Asn Lys Cys Leu Lys Val Phe Ser Ser 
                405                 410                 415     


Leu Ser Phe Leu Val Gln His Gln Ser Ile His Thr Glu Glu Lys Pro 
            420                 425                 430         


Phe Glu Cys Gln Lys Cys Arg Lys Ser Phe Asn Gln Leu Glu Ser Leu 
        435                 440                 445             


Asn Met His Leu Arg Asn His Ile Arg Leu Lys Pro Tyr Glu Cys Ser 
    450                 455                 460                 


Ile Cys Gly Lys Ala Phe Ser His Arg Ser Ser Leu Leu Gln His His 
465                 470                 475                 480 


Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Ile Lys Cys Gly Lys 
                485                 490                 495     


Thr Phe Ser Cys Ser Ser Asn Leu Thr Val His Gln Arg Ile His Thr 
            500                 505                 510         


Gly Glu Lys Pro Tyr Lys Cys Asn Glu Cys Gly Lys Ala Phe Ser Lys 
        515                 520                 525             


Gly Ser Asn Leu Thr Ala His Gln Arg Val His Asn Gly Glu Lys Pro 
    530                 535                 540                 


Asn Ser Val Val Ser Val Glu Lys Pro Leu Asp Tyr Met Asn His Tyr 
545                 550                 555                 560 


Thr Cys Glu Lys Ser Tyr Arg Arg Glu Thr Val 
                565                 570     

<210>  3521
<211>  717
<212>  DNA
<213>  Homo sapiens

<400>  3521
ctgggaaatg tcgatcggct gtgggcggcg cactgggtcc gccccgctgt agcctcaggc     60

ctgacggcga ctcccaggct ccgggacgat tctgggcagt gtcgtcccca gaggtcggcg    120

gccgttgccc gctcaccagc gacgcggggc gcctgcgggg acggacactg cccatctcta    180

agataagagc ctggaaagag gactctgttg gctgttggaa attgcagagt aatgcctcag    240

gtgacattta atgatgtggc tatagacttc actcatgaag agtggggatg gctcagttct    300

gctcagaggg acttatacaa ggatgtgatg gtccagaatt atgagaacct ggtctctgta    360

gcaggtcttt ctgtaactaa gccatatgtg atcacgttat tggaggatgg aaaagagccc    420

tggatgatgg agaaaaaact gtcaaaaggt atgattccag attgggaatc aagatgggaa    480

aacaaggaat tatcaacaaa gaaggataat tatgatgaag attcacccca aacagtaata    540

atagaaaaag ttgtaaaaca aagttatgaa ttttcaaatt ctaagaagaa tttggaatat    600

atagagaagt tggaagggaa gcatggaagt caggtagacc atttcagacc agcaattctc    660

acctctagag aaagccccac tgcagacagt gtttacaaat acaatatatt tagaagc       717


<210>  3522
<211>  161
<212>  PRT
<213>  Homo sapiens

<400>  3522


Met Pro Gln Val Thr Phe Asn Asp Val Ala Ile Asp Phe Thr His Glu 
1               5                   10                  15      


Glu Trp Gly Trp Leu Ser Ser Ala Gln Arg Asp Leu Tyr Lys Asp Val 
            20                  25                  30          


Met Val Gln Asn Tyr Glu Asn Leu Val Ser Val Ala Gly Leu Ser Val 
        35                  40                  45              


Thr Lys Pro Tyr Val Ile Thr Leu Leu Glu Asp Gly Lys Glu Pro Trp 
    50                  55                  60                  


Met Met Glu Lys Lys Leu Ser Lys Gly Met Ile Pro Asp Trp Glu Ser 
65                  70                  75                  80  


Arg Trp Glu Asn Lys Glu Leu Ser Thr Lys Lys Asp Asn Tyr Asp Glu 
                85                  90                  95      


Asp Ser Pro Gln Thr Val Ile Ile Glu Lys Val Val Lys Gln Ser Tyr 
            100                 105                 110         


Glu Phe Ser Asn Ser Lys Lys Asn Leu Glu Tyr Ile Glu Lys Leu Glu 
        115                 120                 125             


Gly Lys His Gly Ser Gln Val Asp His Phe Arg Pro Ala Ile Leu Thr 
    130                 135                 140                 


Ser Arg Glu Ser Pro Thr Ala Asp Ser Val Tyr Lys Tyr Asn Ile Phe 
145                 150                 155                 160 


Arg 
    

<210>  3523
<211>  2742
<212>  DNA
<213>  Homo sapiens

<400>  3523
ctgggaaatg tcgatcggct gtgggcggcg cactgggtcc gccccgctgt agcctcaggc     60

ctgacggcga ctcccaggct ccgggacgat tctgggcagt gtcgtcccca gaggtcggcg    120

gccgttgccc gctcaccagc gacgcggggc gcctgcgggg acggacactg cccatctcta    180

agataagagc ctggaaagag gactctgttg gctgttggaa attgcagagt aatgcctcag    240

gtgacattta atgatgtggc tatagacttc actcatgaag agtggggatg gctcagttct    300

gctcagaggg acttatacaa ggatgtgatg gtccagaatt atgagaacct ggtctctgta    360

gcaggtcttt ctgtaactaa gccatatgtg atcacgttat tggaggatgg aaaagagccc    420

tggatgatgg agaaaaaact gtcaaaaggt atgattccag attgggaatc aagatgggaa    480

aacaaggaat tatcaacaaa gaaggataat tatgatgaag attcacccca aacagtaata    540

atagaaaaag ttgtaaaaca aagttatgaa ttttcaaatt ctaagaagaa tttggaatat    600

atagagaagt tggaagggaa gcatggaagt caggtagacc atttcagacc agcaattctc    660

acctctagag aaagccccac tgcagacagt gtttacaaat acaatatatt tagaagcacc    720

tttcattcaa agtctactct ttctgaacca caaaaaattt ctgctgaagg gaattcacac    780

aaatatgata tattaaagaa gaacttacca aaaaagtcag ttataaaaaa tgagaaagtc    840

aatggtggaa agaaactttt gaattctaat aaaagtgggg cagccttcag ccagggcaaa    900

tctcttaccc ttccccagac ttgtaataga gagaaaatct atacatgcag tgaatgtggg    960

aaagcctttg gcaaacagtc aatcctcaat cgccactgga gaattcatac aggagagaag   1020

ccctatgaat gtcgtgaatg tgggaagact tttagccatg gctcatccct tacacgacat   1080

ctgataagcc atagtggaga gaaaccttac aaatgtattg aatgtgggaa ggcctttagc   1140

catgtctcat cacttactaa ccatcagagc actcacactg gagagaaacc atatgaatgt   1200

atgaactgtg gaaagtcttt tagtcgtgtg tcccatctta ttgaacatct aagaattcat   1260

actcaagaaa aactctatga gtgtcgtata tgtggaaagg ccttcattca taggtcatct   1320

ctcattcacc atcagaaaat ccatactgga gagaagcctt atgaatgtag agaatgtggg   1380

aaagctttct gctgtagctc acaccttact cgacatcaaa gaattcacac tatggagaaa   1440

caatatgaat gcaacaaatg tctgaaagtc tttagtagcc tctcatttct tgttcagcat   1500

cagagtattc atactgaaga aaaacccttt gaatgtcaga aatgcaggaa atccttcaac   1560

cagcttgaat cactgaatat gcatttgaga aatcacatta gattgaaacc ctacgaatgc   1620

agtatatgtg ggaaagcctt tagtcatagg tcatccctgc ttcaacatca cagaattcat   1680

actggagaga aaccttatga atgtattaaa tgtgggaaga ccttcagctg tagttcaaac   1740

cttaccgtac atcagagaat tcacactgga gaaaagccat ataaatgtaa tgagtgtggg   1800

aaagctttta gcaaaggctc aaatcttact gcccatcaaa gagtacataa tggagagaaa   1860

cccaatagtg tggtaagtgt ggaaaagcct ttagactata tgaatcacta tacatgtgag   1920

aaatcttaca gaagagaaac tgtatgaagc agtggttatc atggtaaatt tcctagattc   1980

tcccttattt aacattagaa aaatttatac tggggaaagt cttatgaatg tggtgaatat   2040

aggaagacct tttagcaaag atgcaggcca gtttgtttat tagactttat actgtagaga   2100

aatcatatga agaccataaa tgtgggaaag cctttgtcag tattaatccc ttaattgaca   2160

taagtatact cacactagga taaaaccctg tacatgtagc aaatgtggga aagactacag   2220

acaataggaa tcttttacaa actcctacag gagagaagct gtatgaatgt agaaaattta   2280

gaaattgagg gaagtcttca gttccaagta tatcccttat tctacagcag agaactcaaa   2340

atggagagaa atctcattta agagatgtag caaagtgttc actaagagtg tttatcttgg   2400

tacacatcag aagattaatg gtagaacaac ctgaaggatt taggagttat gtgtaaatct   2460

ttgcagtcat gctatttgta aactggattc tacaggagag caaataaaca ttataataaa   2520

atatgcattt cttagagcag tagcttgcag tttcagttga gttctactta gaaattcttt   2580

ttagctagtg ggcatgtgaa gatatttagt cacccagagg agccagtaag tgttataata   2640

ttgaaaatta aagctgcaaa agaaataaag tgatgttaat aaaagttttg gcatctaata   2700

aaatcatttt gtatatcaca aactctttca ctgtgactat tt                      2742


<210>  3524
<211>  571
<212>  PRT
<213>  Homo sapiens

<400>  3524


Met Pro Gln Val Thr Phe Asn Asp Val Ala Ile Asp Phe Thr His Glu 
1               5                   10                  15      


Glu Trp Gly Trp Leu Ser Ser Ala Gln Arg Asp Leu Tyr Lys Asp Val 
            20                  25                  30          


Met Val Gln Asn Tyr Glu Asn Leu Val Ser Val Ala Gly Leu Ser Val 
        35                  40                  45              


Thr Lys Pro Tyr Val Ile Thr Leu Leu Glu Asp Gly Lys Glu Pro Trp 
    50                  55                  60                  


Met Met Glu Lys Lys Leu Ser Lys Gly Met Ile Pro Asp Trp Glu Ser 
65                  70                  75                  80  


Arg Trp Glu Asn Lys Glu Leu Ser Thr Lys Lys Asp Asn Tyr Asp Glu 
                85                  90                  95      


Asp Ser Pro Gln Thr Val Ile Ile Glu Lys Val Val Lys Gln Ser Tyr 
            100                 105                 110         


Glu Phe Ser Asn Ser Lys Lys Asn Leu Glu Tyr Ile Glu Lys Leu Glu 
        115                 120                 125             


Gly Lys His Gly Ser Gln Val Asp His Phe Arg Pro Ala Ile Leu Thr 
    130                 135                 140                 


Ser Arg Glu Ser Pro Thr Ala Asp Ser Val Tyr Lys Tyr Asn Ile Phe 
145                 150                 155                 160 


Arg Ser Thr Phe His Ser Lys Ser Thr Leu Ser Glu Pro Gln Lys Ile 
                165                 170                 175     


Ser Ala Glu Gly Asn Ser His Lys Tyr Asp Ile Leu Lys Lys Asn Leu 
            180                 185                 190         


Pro Lys Lys Ser Val Ile Lys Asn Glu Lys Val Asn Gly Gly Lys Lys 
        195                 200                 205             


Leu Leu Asn Ser Asn Lys Ser Gly Ala Ala Phe Ser Gln Gly Lys Ser 
    210                 215                 220                 


Leu Thr Leu Pro Gln Thr Cys Asn Arg Glu Lys Ile Tyr Thr Cys Ser 
225                 230                 235                 240 


Glu Cys Gly Lys Ala Phe Gly Lys Gln Ser Ile Leu Asn Arg His Trp 
                245                 250                 255     


Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Arg Glu Cys Gly Lys 
            260                 265                 270         


Thr Phe Ser His Gly Ser Ser Leu Thr Arg His Leu Ile Ser His Ser 
        275                 280                 285             


Gly Glu Lys Pro Tyr Lys Cys Ile Glu Cys Gly Lys Ala Phe Ser His 
    290                 295                 300                 


Val Ser Ser Leu Thr Asn His Gln Ser Thr His Thr Gly Glu Lys Pro 
305                 310                 315                 320 


Tyr Glu Cys Met Asn Cys Gly Lys Ser Phe Ser Arg Val Ser His Leu 
                325                 330                 335     


Ile Glu His Leu Arg Ile His Thr Gln Glu Lys Leu Tyr Glu Cys Arg 
            340                 345                 350         


Ile Cys Gly Lys Ala Phe Ile His Arg Ser Ser Leu Ile His His Gln 
        355                 360                 365             


Lys Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Arg Glu Cys Gly Lys 
    370                 375                 380                 


Ala Phe Cys Cys Ser Ser His Leu Thr Arg His Gln Arg Ile His Thr 
385                 390                 395                 400 


Met Glu Lys Gln Tyr Glu Cys Asn Lys Cys Leu Lys Val Phe Ser Ser 
                405                 410                 415     


Leu Ser Phe Leu Val Gln His Gln Ser Ile His Thr Glu Glu Lys Pro 
            420                 425                 430         


Phe Glu Cys Gln Lys Cys Arg Lys Ser Phe Asn Gln Leu Glu Ser Leu 
        435                 440                 445             


Asn Met His Leu Arg Asn His Ile Arg Leu Lys Pro Tyr Glu Cys Ser 
    450                 455                 460                 


Ile Cys Gly Lys Ala Phe Ser His Arg Ser Ser Leu Leu Gln His His 
465                 470                 475                 480 


Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Ile Lys Cys Gly Lys 
                485                 490                 495     


Thr Phe Ser Cys Ser Ser Asn Leu Thr Val His Gln Arg Ile His Thr 
            500                 505                 510         


Gly Glu Lys Pro Tyr Lys Cys Asn Glu Cys Gly Lys Ala Phe Ser Lys 
        515                 520                 525             


Gly Ser Asn Leu Thr Ala His Gln Arg Val His Asn Gly Glu Lys Pro 
    530                 535                 540                 


Asn Ser Val Val Ser Val Glu Lys Pro Leu Asp Tyr Met Asn His Tyr 
545                 550                 555                 560 


Thr Cys Glu Lys Ser Tyr Arg Arg Glu Thr Val 
                565                 570     

<210>  3525
<211>  2580
<212>  DNA
<213>  Homo sapiens

<400>  3525
aaatgtcgat cggctgtggg cggcgcactg ggtccgcccc gctgtagcct caggcctgac     60

ggcgactccc aggctccggt gacatttaat gatgtggcta tagacttcac tcatgaagag    120

tggggatggc tcagttctgc tcagagggac ttatacaagg atgtgatggt ccagaattat    180

gagaacctgg tctctgtagc aggtctttct gtaactaagc catatgtgat cacgttattg    240

gaggatggaa aagagccctg gatgatggag aaaaaactgt caaaaggtat gattccagat    300

tgggaatcaa gatgggaaaa caaggaatta tcaacaaaga aggataatta tgatgaagat    360

tcaccccaaa cagtaataat agaaaaagtt gtaaaacaaa gttatgaatt ttcaaattct    420

aagaagaatt tggaatatat agagaagttg gaagggaagc atggaagtca ggtagaccat    480

ttcagaccag caattctcac ctctagagaa agccccactg cagacagtgt ttacaaatac    540

aatatattta gaagcacctt tcattcaaag tctactcttt ctgaaccaca aaaaatttct    600

gctgaaggga attcacacaa atatgatata ttaaagaaga acttaccaaa aaagtcagtt    660

ataaaaaatg agaaagtcaa tggtggaaag aaacttttga attctaataa aagtggggca    720

gccttcagcc agggcaaatc tcttaccctt ccccagactt gtaatagaga gaaaatctat    780

acatgcagtg aatgtgggaa agcctttggc aaacagtcaa tcctcaatcg ccactggaga    840

attcatacag gagagaagcc ctatgaatgt cgtgaatgtg ggaagacttt tagccatggc    900

tcatccctta cacgacatct gataagccat agtggagaga aaccttacaa atgtattgaa    960

tgtgggaagg cctttagcca tgtctcatca cttactaacc atcagagcac tcacactgga   1020

gagaaaccat atgaatgtat gaactgtgga aagtctttta gtcgtgtgtc ccatcttatt   1080

gaacatctaa gaattcatac tcaagaaaaa ctctatgagt gtcgtatatg tggaaaggcc   1140

ttcattcata ggtcatctct cattcaccat cagaaaatcc atactggaga gaagccttat   1200

gaatgtagag aatgtgggaa agctttctgc tgtagctcac accttactcg acatcaaaga   1260

attcacacta tggagaaaca atatgaatgc aacaaatgtc tgaaagtctt tagtagcctc   1320

tcatttcttg ttcagcatca gagtattcat actgaagaaa aaccctttga atgtcagaaa   1380

tgcaggaaat ccttcaacca gcttgaatca ctgaatatgc atttgagaaa tcacattaga   1440

ttgaaaccct acgaatgcag tatatgtggg aaagccttta gtcataggtc atccctgctt   1500

caacatcaca gaattcatac tggagagaaa ccttatgaat gtattaaatg tgggaagacc   1560

ttcagctgta gttcaaacct taccgtacat cagagaattc acactggaga aaagccatat   1620

aaatgtaatg agtgtgggaa agcttttagc aaaggctcaa atcttactgc ccatcaaaga   1680

gtacataatg gagagaaacc caatagtgtg gtaagtgtgg aaaagccttt agactatatg   1740

aatcactata catgtgagaa atcttacaga agagaaactg tatgaagcag tggttatcat   1800

ggtaaatttc ctagattctc ccttatttaa cattagaaaa atttatactg gggaaagtct   1860

tatgaatgtg gtgaatatag gaagaccttt tagcaaagat gcaggccagt ttgtttatta   1920

gactttatac tgtagagaaa tcatatgaag accataaatg tgggaaagcc tttgtcagta   1980

ttaatccctt aattgacata agtatactca cactaggata aaaccctgta catgtagcaa   2040

atgtgggaaa gactacagac aataggaatc ttttacaaac tcctacagga gagaagctgt   2100

atgaatgtag aaaatttaga aattgaggga agtcttcagt tccaagtata tcccttattc   2160

tacagcagag aactcaaaat ggagagaaat ctcatttaag agatgtagca aagtgttcac   2220

taagagtgtt tatcttggta cacatcagaa gattaatggt agaacaacct gaaggattta   2280

ggagttatgt gtaaatcttt gcagtcatgc tatttgtaaa ctggattcta caggagagca   2340

aataaacatt ataataaaat atgcatttct tagagcagta gcttgcagtt tcagttgagt   2400

tctacttaga aattcttttt agctagtggg catgtgaaga tatttagtca cccagaggag   2460

ccagtaagtg ttataatatt gaaaattaaa gctgcaaaag aaataaagtg atgttaataa   2520

aagttttggc atctaataaa atcattttgt atatcacaaa ctctttcact gtgactattt   2580


<210>  3526
<211>  539
<212>  PRT
<213>  Homo sapiens

<400>  3526


Met Val Gln Asn Tyr Glu Asn Leu Val Ser Val Ala Gly Leu Ser Val 
1               5                   10                  15      


Thr Lys Pro Tyr Val Ile Thr Leu Leu Glu Asp Gly Lys Glu Pro Trp 
            20                  25                  30          


Met Met Glu Lys Lys Leu Ser Lys Gly Met Ile Pro Asp Trp Glu Ser 
        35                  40                  45              


Arg Trp Glu Asn Lys Glu Leu Ser Thr Lys Lys Asp Asn Tyr Asp Glu 
    50                  55                  60                  


Asp Ser Pro Gln Thr Val Ile Ile Glu Lys Val Val Lys Gln Ser Tyr 
65                  70                  75                  80  


Glu Phe Ser Asn Ser Lys Lys Asn Leu Glu Tyr Ile Glu Lys Leu Glu 
                85                  90                  95      


Gly Lys His Gly Ser Gln Val Asp His Phe Arg Pro Ala Ile Leu Thr 
            100                 105                 110         


Ser Arg Glu Ser Pro Thr Ala Asp Ser Val Tyr Lys Tyr Asn Ile Phe 
        115                 120                 125             


Arg Ser Thr Phe His Ser Lys Ser Thr Leu Ser Glu Pro Gln Lys Ile 
    130                 135                 140                 


Ser Ala Glu Gly Asn Ser His Lys Tyr Asp Ile Leu Lys Lys Asn Leu 
145                 150                 155                 160 


Pro Lys Lys Ser Val Ile Lys Asn Glu Lys Val Asn Gly Gly Lys Lys 
                165                 170                 175     


Leu Leu Asn Ser Asn Lys Ser Gly Ala Ala Phe Ser Gln Gly Lys Ser 
            180                 185                 190         


Leu Thr Leu Pro Gln Thr Cys Asn Arg Glu Lys Ile Tyr Thr Cys Ser 
        195                 200                 205             


Glu Cys Gly Lys Ala Phe Gly Lys Gln Ser Ile Leu Asn Arg His Trp 
    210                 215                 220                 


Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Arg Glu Cys Gly Lys 
225                 230                 235                 240 


Thr Phe Ser His Gly Ser Ser Leu Thr Arg His Leu Ile Ser His Ser 
                245                 250                 255     


Gly Glu Lys Pro Tyr Lys Cys Ile Glu Cys Gly Lys Ala Phe Ser His 
            260                 265                 270         


Val Ser Ser Leu Thr Asn His Gln Ser Thr His Thr Gly Glu Lys Pro 
        275                 280                 285             


Tyr Glu Cys Met Asn Cys Gly Lys Ser Phe Ser Arg Val Ser His Leu 
    290                 295                 300                 


Ile Glu His Leu Arg Ile His Thr Gln Glu Lys Leu Tyr Glu Cys Arg 
305                 310                 315                 320 


Ile Cys Gly Lys Ala Phe Ile His Arg Ser Ser Leu Ile His His Gln 
                325                 330                 335     


Lys Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Arg Glu Cys Gly Lys 
            340                 345                 350         


Ala Phe Cys Cys Ser Ser His Leu Thr Arg His Gln Arg Ile His Thr 
        355                 360                 365             


Met Glu Lys Gln Tyr Glu Cys Asn Lys Cys Leu Lys Val Phe Ser Ser 
    370                 375                 380                 


Leu Ser Phe Leu Val Gln His Gln Ser Ile His Thr Glu Glu Lys Pro 
385                 390                 395                 400 


Phe Glu Cys Gln Lys Cys Arg Lys Ser Phe Asn Gln Leu Glu Ser Leu 
                405                 410                 415     


Asn Met His Leu Arg Asn His Ile Arg Leu Lys Pro Tyr Glu Cys Ser 
            420                 425                 430         


Ile Cys Gly Lys Ala Phe Ser His Arg Ser Ser Leu Leu Gln His His 
        435                 440                 445             


Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Ile Lys Cys Gly Lys 
    450                 455                 460                 


Thr Phe Ser Cys Ser Ser Asn Leu Thr Val His Gln Arg Ile His Thr 
465                 470                 475                 480 


Gly Glu Lys Pro Tyr Lys Cys Asn Glu Cys Gly Lys Ala Phe Ser Lys 
                485                 490                 495     


Gly Ser Asn Leu Thr Ala His Gln Arg Val His Asn Gly Glu Lys Pro 
            500                 505                 510         


Asn Ser Val Val Ser Val Glu Lys Pro Leu Asp Tyr Met Asn His Tyr 
        515                 520                 525             


Thr Cys Glu Lys Ser Tyr Arg Arg Glu Thr Val 
    530                 535                 

<210>  3527
<211>  3619
<212>  DNA
<213>  Homo sapiens

<400>  3527
atcatattaa ataattatct tcattttcct taggaatctc catctcaagg ctcagagaga     60

tgaactgctg gcgcagggat acacagggag gaaagtcaag gcgtgagttg cctggtagag    120

acatttgaga gtgggtcatt gcctcagata atttccacgg aactctgtgt gcctctcctt    180

taagaagagg tgaagccaat ccctttcttg ggagccttga gaagccgcct caccgagaac    240

agaaagtgcg ctccaggtac cacccggatt ccgtcaaact acattaccca gaaggcagtg    300

ctacaaggga cggaagccga ccccaagcca tagacggaag gcgcagaggg gcgttcccgt    360

agcggcgtgg gcgggacttc cggcgtccag tcttcgtccg ccgttaggtt gcggctgctg    420

tggttgccaa cgctacactg ggtagaacgc cagacagggg ccacttttcg agaccgagta    480

gagacggaca gtgaggagga taggacccac ttacacgctt ttatgtcagc cgcgatccca    540

cccccacaag cgtctgcaaa acccttcctg gggccttggc gacagccctg tgtcctcacg    600

gcgcgcagag gcggcgccgc gaaccttgtg tgcattttac acgacggcgg ggactgaggt    660

ccctcgcagc ccagagccgg agcccggggt cggccgagcc cgcaggaccg gcttcctcgc    720

cgactctcac ggcctcaccc agccccctgg gcccatggcg gcgccggcgt tgtgctcgga    780

gagcatcact ctaggtgccg tctttgaaga aggactctct aggtcctgct gttgttttag    840

gggatcattc cagcggaagt ctggccctac caaaagctgg gagagggaat gagagcctcg    900

agggcaagag gcattagtat catttgaaga cgtggttgtg accttcactg gagaggaatg    960

ggggcacctg gacctggccc agaggaccct gtaccaggag gtgatgctgg agacctgcag   1020

gctcctggtc tcactggggc atcctgttcc caaaccagag ctgatctatc tactggaaca   1080

tggacaggaa ctgtggacag tgaagagagg cctctcccaa agcacctgcg caggtgaaaa   1140

agcaaaaccc aagattacag agcctactgc ttctcagctg gccttctctg aggaatcctc   1200

tttccaggaa cttctggcac agagatcctc aagagattcc aggttggggc aagctagaga   1260

tgaggaaaag ctaataaaaa ttcaggaagg gaacttgagg ccaggaacaa acccccacaa   1320

agagatatgc cctgagaagt tgagttataa acatgatgat ttggagccag atgatagtct   1380

gggcttaagg gttttacagg aacgagtcac tccacaagat gctctccatg agtgtgactc   1440

tcaaggacca ggaaaagacc ccatgactga tgcaaggaat aacccttaca catgcacgga   1500

atgtgggaaa gggtttagca agaagtgggc ccttgttcgg catcaacaga ttcatgctgg   1560

agtgaagccc tatgagtgca atgagtgtgg gaaagcctgt cgttatatgg ctgatgtcat   1620

tcgacatatg aggcttcata ctggggaaaa accatacaag tgtattgagt gtgggaaagc   1680

cttcaaacgc aggtttcacc tcacggagca ccagcgtatt cacaccggag ataagcccta   1740

tgagtgcaaa gaatgtggca aagcattcac ccaccgctct tcttttatcc agcataatat   1800

gactcacact cgagaaaaac cctttttatg caaagaatgt gggaaagctt tttactacag   1860

ctcctcattt gctcaacata tgaggattca tactggaaag aaactctatg agtgcggtga   1920

atgtggaaag gccttcacgc accgctccac atttatccag cacaatgtga cccacacagg   1980

agaaaaacca tttttatgta aagaatgtgg aaaaaccttt tgcctcaact catccttcac   2040

tcagcacatg aggattcaca ctggagagaa accctatgag tgcggtgaat gtggaaaggc   2100

ctttactcat cgctccactt tcatccgaca taagaggacc cataccggag agaagccctt   2160

tgagtgcaaa gaatgtggga aggccttttg tgacagctct tccttaattc aacatatgag   2220

gattcacact ggtgagaagc cttatgagtg cagtgaatgt ggaaaggctt ttacacacca   2280

ctctgttttt attcgacata ataggaccca cagtggacaa aaacccttgg agtgcaaaga   2340

atgtgcaaaa gccttttact atagctcttc cttcactcga cacatgagga ttcacactgg   2400

agagaagccc tatgtttgta gagaatgtgg aaaggctttt acccaacctg caaattttgt   2460

tcggcataat aggatccaca ctggagaaaa accttttgaa tgcaaagaat gtgagaaagc   2520

cttctgtgac aactttgctt taactcagca catgagaact cacactggag agaaaccctt   2580

tgaatgcaat gaatgtggaa agaccttcag ccacagttca tcgttcactc accatcgaaa   2640

gattcatacc agagtttaaa agatacagga aggcctatta caagtgtgtt tgtctttagt   2700

gaactcatag tggtgacata cctttccttt tgagtataac tattgaggga aatattttgg   2760

ccagagagat gtcttagtat ctgataattt atactaacta gaaacagaat tgtccctgtg   2820

aaatcttttt atggcaggta atcacttgtc atccaaagaa ttatattaaa gattcaccca   2880

gtttagagcc ttacactgta cctgagaata atcgagggga gagacctggt ggttaacatg   2940

catttaggta aaatgtcagg aacaactttc ctcttattaa tactataaat ccatctcaag   3000

catattttaa aataatgaga gatggaggaa acaatctaga agataaaaga aaaagatgtg   3060

cataacttgt tttcagtttc cctgtttatg acagtttgtc atttggcggg ttgggggatg   3120

gagcagggaa taagacattg aaaaagtctc atcccctttg tgtgttttac atatatatat   3180

ctctaagtcc agagccagga gagttggacc attgagggca gctctgccaa catttagtaa   3240

aagtattcat tgttccaaaa ctgtcatctc tacccttgag ggagtgtgtc tttgtgagaa   3300

atataaaggc ttgagtcatg aaatacttaa cacatgtgca catgtacaca tgtacattta   3360

tatgcagtga attgttactc gtggtagtta ggttctgtga attttctgtg cacactgaat   3420

tagtgaatgc tgaatgattg ttgctagggg aaatacagcg ttagcttctg tgagcctctg   3480

atccaaacat ttttatcaac cagtcaacac ataaccttct tctatgggta tttgtttgtt   3540

tgtttgttta aagacacttt atcagtgttt cttgaataat tataattatt ctttataata   3600

aaaatatttt aattatagc                                                3619


<210>  3528
<211>  551
<212>  PRT
<213>  Homo sapiens

<400>  3528


Met Leu Glu Thr Cys Arg Leu Leu Val Ser Leu Gly His Pro Val Pro 
1               5                   10                  15      


Lys Pro Glu Leu Ile Tyr Leu Leu Glu His Gly Gln Glu Leu Trp Thr 
            20                  25                  30          


Val Lys Arg Gly Leu Ser Gln Ser Thr Cys Ala Gly Glu Lys Ala Lys 
        35                  40                  45              


Pro Lys Ile Thr Glu Pro Thr Ala Ser Gln Leu Ala Phe Ser Glu Glu 
    50                  55                  60                  


Ser Ser Phe Gln Glu Leu Leu Ala Gln Arg Ser Ser Arg Asp Ser Arg 
65                  70                  75                  80  


Leu Gly Gln Ala Arg Asp Glu Glu Lys Leu Ile Lys Ile Gln Glu Gly 
                85                  90                  95      


Asn Leu Arg Pro Gly Thr Asn Pro His Lys Glu Ile Cys Pro Glu Lys 
            100                 105                 110         


Leu Ser Tyr Lys His Asp Asp Leu Glu Pro Asp Asp Ser Leu Gly Leu 
        115                 120                 125             


Arg Val Leu Gln Glu Arg Val Thr Pro Gln Asp Ala Leu His Glu Cys 
    130                 135                 140                 


Asp Ser Gln Gly Pro Gly Lys Asp Pro Met Thr Asp Ala Arg Asn Asn 
145                 150                 155                 160 


Pro Tyr Thr Cys Thr Glu Cys Gly Lys Gly Phe Ser Lys Lys Trp Ala 
                165                 170                 175     


Leu Val Arg His Gln Gln Ile His Ala Gly Val Lys Pro Tyr Glu Cys 
            180                 185                 190         


Asn Glu Cys Gly Lys Ala Cys Arg Tyr Met Ala Asp Val Ile Arg His 
        195                 200                 205             


Met Arg Leu His Thr Gly Glu Lys Pro Tyr Lys Cys Ile Glu Cys Gly 
    210                 215                 220                 


Lys Ala Phe Lys Arg Arg Phe His Leu Thr Glu His Gln Arg Ile His 
225                 230                 235                 240 


Thr Gly Asp Lys Pro Tyr Glu Cys Lys Glu Cys Gly Lys Ala Phe Thr 
                245                 250                 255     


His Arg Ser Ser Phe Ile Gln His Asn Met Thr His Thr Arg Glu Lys 
            260                 265                 270         


Pro Phe Leu Cys Lys Glu Cys Gly Lys Ala Phe Tyr Tyr Ser Ser Ser 
        275                 280                 285             


Phe Ala Gln His Met Arg Ile His Thr Gly Lys Lys Leu Tyr Glu Cys 
    290                 295                 300                 


Gly Glu Cys Gly Lys Ala Phe Thr His Arg Ser Thr Phe Ile Gln His 
305                 310                 315                 320 


Asn Val Thr His Thr Gly Glu Lys Pro Phe Leu Cys Lys Glu Cys Gly 
                325                 330                 335     


Lys Thr Phe Cys Leu Asn Ser Ser Phe Thr Gln His Met Arg Ile His 
            340                 345                 350         


Thr Gly Glu Lys Pro Tyr Glu Cys Gly Glu Cys Gly Lys Ala Phe Thr 
        355                 360                 365             


His Arg Ser Thr Phe Ile Arg His Lys Arg Thr His Thr Gly Glu Lys 
    370                 375                 380                 


Pro Phe Glu Cys Lys Glu Cys Gly Lys Ala Phe Cys Asp Ser Ser Ser 
385                 390                 395                 400 


Leu Ile Gln His Met Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys 
                405                 410                 415     


Ser Glu Cys Gly Lys Ala Phe Thr His His Ser Val Phe Ile Arg His 
            420                 425                 430         


Asn Arg Thr His Ser Gly Gln Lys Pro Leu Glu Cys Lys Glu Cys Ala 
        435                 440                 445             


Lys Ala Phe Tyr Tyr Ser Ser Ser Phe Thr Arg His Met Arg Ile His 
    450                 455                 460                 


Thr Gly Glu Lys Pro Tyr Val Cys Arg Glu Cys Gly Lys Ala Phe Thr 
465                 470                 475                 480 


Gln Pro Ala Asn Phe Val Arg His Asn Arg Ile His Thr Gly Glu Lys 
                485                 490                 495     


Pro Phe Glu Cys Lys Glu Cys Glu Lys Ala Phe Cys Asp Asn Phe Ala 
            500                 505                 510         


Leu Thr Gln His Met Arg Thr His Thr Gly Glu Lys Pro Phe Glu Cys 
        515                 520                 525             


Asn Glu Cys Gly Lys Thr Phe Ser His Ser Ser Ser Phe Thr His His 
    530                 535                 540                 


Arg Lys Ile His Thr Arg Val 
545                 550     

<210>  3529
<211>  3481
<212>  DNA
<213>  Homo sapiens

<400>  3529
atcatattaa ataattatct tcattttcct taggaatctc catctcaagg ctcagagaga     60

tgaactgctg gcgcagggat acacagggag gaaagtcaag gcgtgagttg cctggtagag    120

acatttgaga gtgggtcatt gcctcagata atttccacgg aactctgtgt gcctctcctt    180

taagaagagg tgaagccaat ccctttcttg ggagccttga gaagccgcct caccgagaac    240

agaaagtgcg ctccaggtac cacccggatt ccgtcaaact acattaccca gaaggcagtg    300

ctacaaggga cggaagccga ccccaagcca tagacggaag gcgcagaggg gcgttcccgt    360

agcggcgtgg gcgggacttc cggcgtccag tcttcgtccg ccgttaggtt gcggctgctg    420

tggttgccaa cgctacactg ggtagaacgc cagacagggg ccacttttcg agaccgagta    480

gagacggaca gtgaggagga taggacccac ttacacgctt ttatgtcagc cgcgatccca    540

cccccacaag cgtctgcaaa acccttcctg gggccttggc gacagccctg tgtcctcacg    600

gcgcgcagag gcggcgccgc gaaccttgtg tgcattttac acgacggcgg ggactgaggt    660

ccctcgcagc ccagagccgg agcccggggt cggccgagcc cgcaggaccg gcttcctcgc    720

cgactctcac ggcctcaccc agccccctgg gcccatggcg gcgccggcgt tggcattagt    780

atcatttgaa gacgtggttg tgaccttcac tggagaggaa tgggggcacc tggacctggc    840

ccagaggacc ctgtaccagg aggtgatgct ggagacctgc aggctcctgg tctcactggg    900

gcatcctgtt cccaaaccag agctgatcta tctactggaa catggacagg aactgtggac    960

agtgaagaga ggcctctccc aaagcacctg cgcaggtgaa aaagcaaaac ccaagattac   1020

agagcctact gcttctcagc tggccttctc tgaggaatcc tctttccagg aacttctggc   1080

acagagatcc tcaagagatt ccaggttggg gcaagctaga gatgaggaaa agctaataaa   1140

aattcaggaa gggaacttga ggccaggaac aaacccccac aaagagatat gccctgagaa   1200

gttgagttat aaacatgatg atttggagcc agatgatagt ctgggcttaa gggttttaca   1260

ggaacgagtc actccacaag atgctctcca tgagtgtgac tctcaaggac caggaaaaga   1320

ccccatgact gatgcaagga ataaccctta cacatgcacg gaatgtggga aagggtttag   1380

caagaagtgg gcccttgttc ggcatcaaca gattcatgct ggagtgaagc cctatgagtg   1440

caatgagtgt gggaaagcct gtcgttatat ggctgatgtc attcgacata tgaggcttca   1500

tactggggaa aaaccataca agtgtattga gtgtgggaaa gccttcaaac gcaggtttca   1560

cctcacggag caccagcgta ttcacaccgg agataagccc tatgagtgca aagaatgtgg   1620

caaagcattc acccaccgct cttcttttat ccagcataat atgactcaca ctcgagaaaa   1680

acccttttta tgcaaagaat gtgggaaagc tttttactac agctcctcat ttgctcaaca   1740

tatgaggatt catactggaa agaaactcta tgagtgcggt gaatgtggaa aggccttcac   1800

gcaccgctcc acatttatcc agcacaatgt gacccacaca ggagaaaaac catttttatg   1860

taaagaatgt ggaaaaacct tttgcctcaa ctcatccttc actcagcaca tgaggattca   1920

cactggagag aaaccctatg agtgcggtga atgtggaaag gcctttactc atcgctccac   1980

tttcatccga cataagagga cccataccgg agagaagccc tttgagtgca aagaatgtgg   2040

gaaggccttt tgtgacagct cttccttaat tcaacatatg aggattcaca ctggtgagaa   2100

gccttatgag tgcagtgaat gtggaaaggc ttttacacac cactctgttt ttattcgaca   2160

taataggacc cacagtggac aaaaaccctt ggagtgcaaa gaatgtgcaa aagcctttta   2220

ctatagctct tccttcactc gacacatgag gattcacact ggagagaagc cctatgtttg   2280

tagagaatgt ggaaaggctt ttacccaacc tgcaaatttt gttcggcata ataggatcca   2340

cactggagaa aaaccttttg aatgcaaaga atgtgagaaa gccttctgtg acaactttgc   2400

tttaactcag cacatgagaa ctcacactgg agagaaaccc tttgaatgca atgaatgtgg   2460

aaagaccttc agccacagtt catcgttcac tcaccatcga aagattcata ccagagttta   2520

aaagatacag gaaggcctat tacaagtgtg tttgtcttta gtgaactcat agtggtgaca   2580

tacctttcct tttgagtata actattgagg gaaatatttt ggccagagag atgtcttagt   2640

atctgataat ttatactaac tagaaacaga attgtccctg tgaaatcttt ttatggcagg   2700

taatcacttg tcatccaaag aattatatta aagattcacc cagtttagag ccttacactg   2760

tacctgagaa taatcgaggg gagagacctg gtggttaaca tgcatttagg taaaatgtca   2820

ggaacaactt tcctcttatt aatactataa atccatctca agcatatttt aaaataatga   2880

gagatggagg aaacaatcta gaagataaaa gaaaaagatg tgcataactt gttttcagtt   2940

tccctgttta tgacagtttg tcatttggcg ggttggggga tggagcaggg aataagacat   3000

tgaaaaagtc tcatcccctt tgtgtgtttt acatatatat atctctaagt ccagagccag   3060

gagagttgga ccattgaggg cagctctgcc aacatttagt aaaagtattc attgttccaa   3120

aactgtcatc tctacccttg agggagtgtg tctttgtgag aaatataaag gcttgagtca   3180

tgaaatactt aacacatgtg cacatgtaca catgtacatt tatatgcagt gaattgttac   3240

tcgtggtagt taggttctgt gaattttctg tgcacactga attagtgaat gctgaatgat   3300

tgttgctagg ggaaatacag cgttagcttc tgtgagcctc tgatccaaac atttttatca   3360

accagtcaac acataacctt cttctatggg tatttgtttg tttgtttgtt taaagacact   3420

ttatcagtgt ttcttgaata attataatta ttctttataa taaaaatatt ttaattatag   3480

c                                                                   3481


<210>  3530
<211>  588
<212>  PRT
<213>  Homo sapiens

<400>  3530


Met Ala Ala Pro Ala Leu Ala Leu Val Ser Phe Glu Asp Val Val Val 
1               5                   10                  15      


Thr Phe Thr Gly Glu Glu Trp Gly His Leu Asp Leu Ala Gln Arg Thr 
            20                  25                  30          


Leu Tyr Gln Glu Val Met Leu Glu Thr Cys Arg Leu Leu Val Ser Leu 
        35                  40                  45              


Gly His Pro Val Pro Lys Pro Glu Leu Ile Tyr Leu Leu Glu His Gly 
    50                  55                  60                  


Gln Glu Leu Trp Thr Val Lys Arg Gly Leu Ser Gln Ser Thr Cys Ala 
65                  70                  75                  80  


Gly Glu Lys Ala Lys Pro Lys Ile Thr Glu Pro Thr Ala Ser Gln Leu 
                85                  90                  95      


Ala Phe Ser Glu Glu Ser Ser Phe Gln Glu Leu Leu Ala Gln Arg Ser 
            100                 105                 110         


Ser Arg Asp Ser Arg Leu Gly Gln Ala Arg Asp Glu Glu Lys Leu Ile 
        115                 120                 125             


Lys Ile Gln Glu Gly Asn Leu Arg Pro Gly Thr Asn Pro His Lys Glu 
    130                 135                 140                 


Ile Cys Pro Glu Lys Leu Ser Tyr Lys His Asp Asp Leu Glu Pro Asp 
145                 150                 155                 160 


Asp Ser Leu Gly Leu Arg Val Leu Gln Glu Arg Val Thr Pro Gln Asp 
                165                 170                 175     


Ala Leu His Glu Cys Asp Ser Gln Gly Pro Gly Lys Asp Pro Met Thr 
            180                 185                 190         


Asp Ala Arg Asn Asn Pro Tyr Thr Cys Thr Glu Cys Gly Lys Gly Phe 
        195                 200                 205             


Ser Lys Lys Trp Ala Leu Val Arg His Gln Gln Ile His Ala Gly Val 
    210                 215                 220                 


Lys Pro Tyr Glu Cys Asn Glu Cys Gly Lys Ala Cys Arg Tyr Met Ala 
225                 230                 235                 240 


Asp Val Ile Arg His Met Arg Leu His Thr Gly Glu Lys Pro Tyr Lys 
                245                 250                 255     


Cys Ile Glu Cys Gly Lys Ala Phe Lys Arg Arg Phe His Leu Thr Glu 
            260                 265                 270         


His Gln Arg Ile His Thr Gly Asp Lys Pro Tyr Glu Cys Lys Glu Cys 
        275                 280                 285             


Gly Lys Ala Phe Thr His Arg Ser Ser Phe Ile Gln His Asn Met Thr 
    290                 295                 300                 


His Thr Arg Glu Lys Pro Phe Leu Cys Lys Glu Cys Gly Lys Ala Phe 
305                 310                 315                 320 


Tyr Tyr Ser Ser Ser Phe Ala Gln His Met Arg Ile His Thr Gly Lys 
                325                 330                 335     


Lys Leu Tyr Glu Cys Gly Glu Cys Gly Lys Ala Phe Thr His Arg Ser 
            340                 345                 350         


Thr Phe Ile Gln His Asn Val Thr His Thr Gly Glu Lys Pro Phe Leu 
        355                 360                 365             


Cys Lys Glu Cys Gly Lys Thr Phe Cys Leu Asn Ser Ser Phe Thr Gln 
    370                 375                 380                 


His Met Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Gly Glu Cys 
385                 390                 395                 400 


Gly Lys Ala Phe Thr His Arg Ser Thr Phe Ile Arg His Lys Arg Thr 
                405                 410                 415     


His Thr Gly Glu Lys Pro Phe Glu Cys Lys Glu Cys Gly Lys Ala Phe 
            420                 425                 430         


Cys Asp Ser Ser Ser Leu Ile Gln His Met Arg Ile His Thr Gly Glu 
        435                 440                 445             


Lys Pro Tyr Glu Cys Ser Glu Cys Gly Lys Ala Phe Thr His His Ser 
    450                 455                 460                 


Val Phe Ile Arg His Asn Arg Thr His Ser Gly Gln Lys Pro Leu Glu 
465                 470                 475                 480 


Cys Lys Glu Cys Ala Lys Ala Phe Tyr Tyr Ser Ser Ser Phe Thr Arg 
                485                 490                 495     


His Met Arg Ile His Thr Gly Glu Lys Pro Tyr Val Cys Arg Glu Cys 
            500                 505                 510         


Gly Lys Ala Phe Thr Gln Pro Ala Asn Phe Val Arg His Asn Arg Ile 
        515                 520                 525             


His Thr Gly Glu Lys Pro Phe Glu Cys Lys Glu Cys Glu Lys Ala Phe 
    530                 535                 540                 


Cys Asp Asn Phe Ala Leu Thr Gln His Met Arg Thr His Thr Gly Glu 
545                 550                 555                 560 


Lys Pro Phe Glu Cys Asn Glu Cys Gly Lys Thr Phe Ser His Ser Ser 
                565                 570                 575     


Ser Phe Thr His His Arg Lys Ile His Thr Arg Val 
            580                 585             

<210>  3531
<211>  3754
<212>  DNA
<213>  Homo sapiens

<400>  3531
atcatattaa ataattatct tcattttcct taggaatctc catctcaagg ctcagagaga     60

tgaactgctg gcgcagggat acacagggag gaaagtcaag gcgtgagttg cctggtagag    120

acatttgaga gtgggtcatt gcctcagata atttccacgg aactctgtgt gcctctcctt    180

taagaagagg tgaagccaat ccctttcttg ggagccttga gaagccgcct caccgagaac    240

agaaagtgcg ctccaggtac cacccggatt ccgtcaaact acattaccca gaaggcagtg    300

ctacaaggga cggaagccga ccccaagcca tagacggaag gcgcagaggg gcgttcccgt    360

agcggcgtgg gcgggacttc cggcgtccag tcttcgtccg ccgttaggtt gcggctgctg    420

tggttgccaa cgctacactg ggtagaacgc cagacagggg ccacttttcg agaccgagta    480

gagacggaca gtgaggagga taggacccac ttacacgctt ttatgtcagc cgcgatccca    540

cccccacaag cgtctgcaaa acccttcctg gggccttggc gacagccctg tgtcctcacg    600

gcgcgcagag gcggcgccgc gaaccttgtg tgcattttac acgacggcgg ggactgaggt    660

ccctcgcagc ccagagccgg agcccggggt cggccgagcc cgcaggaccg gcttcctcgc    720

cgactctcac ggcctcaccc agccccctgg gcccatggcg gcgccggcgt tggcattagt    780

atcatttgaa gacgtggttg tgaccttcac tggagaggaa tgggggcacc tggacctggc    840

ccagaggacc ctgtaccagg aggtgatgct ggagacctgc aggctcctgg tctcactggg    900

gcatcctgtt cccaaaccag agctgatcta tctactggaa catggacagg aactgtggac    960

agtgaagaga ggcctctccc aaagcacctg cgcagcttcc ttctcacttc tgtggaagag   1020

ttatcatcct ggccatggct aatttctcca gcagaatcta gattacactt tctgccttct   1080

caggtgtatt agccatctac tattaatatg taacaatatt accacaaacc ctgcagctga   1140

aaacatcact tatttattat ctcccaccta tggattggga gtccaggcac agcttagctg   1200

ggtcctctca ggcgtgtcat aggcagctca tagctcatca tcaccatcag ctcacttctt   1260

caaatcaagc cactgtgtga gactccagca agacggatgt tccagtctta taaaattaca   1320

tatattttat catgtacatt ccatcatctt tgccatattc tatactttag aagcaaatcg   1380

aggtcctgcc aacattttaa caggggaact acaaaagggt gtgaacacta tgacttgggg   1440

atcatgagaa gccatacgtg aatctctcag ctgcatcagg gaacatgctt cttcacttac   1500

ttcctacctc ttctatattt tcatcccctc tctactcaac attaaaaaaa aatgatgatg   1560

tttctgatac ctgggggaga cttttttttt tttagtgctc ttacgtctcc agcagcatct   1620

acatattgtt gactctattt cacctgaaca gccaagcttg ttggagaagt cttctcattc   1680

tttgaagaga catctacaca agactttcct ttatttattt tttcccttat ttttgtactg   1740

aggtgcaatt tatacataat aagtgtacaa atcataaagt ttcatttcta taaagtttta   1800

tatatgtaca agtcagagaa accatctcac agttcaagaa atacagtgtt ttcagcactt   1860

aacaggctcc ttgtgctcat tctttgtcag tatccccttc tataaaagta gtcagtgttt   1920

atactctata tcaccataca ttagttttga aggcatataa atagaacccc ctagtacata   1980

ctctgtcctg acttcttttg ataatcttta tgactcagat tcattcatgt ggttgcatat   2040

agttggagtt agttcattac catcattgaa tgaatagact acatataccc attttcctat   2100

tgatggacat ttgacttggt ctccattttt ggaatattat gaagactact cttatgaata   2160

ttcttgattg tattttttgt tggatataaa cccatatttc tgttgggaat atacatacaa   2220

gtggactggc cagatcaagt gtgggcatat gattagcttt aatcgaaacc accagtttca   2280

gagtaactac accatttcac atttccacta gccacgtatg agagtcttca ttgttccatg   2340

tacgcctgag cagttggtgt ctttcccttt actctttgat gcctggtagt ggtgtttctc   2400

agcaccacag cacttaaagt gttcttgccc aggtcactgt tgccatcctg attgctaaat   2460

tcaactataa tgataataga cagtggtcta cagtttacca aacatttatt ctttgtcaca   2520

cgaatgaact tttgtttggt ttttgggttt tttttgagac aggatctcac tctgtcgcct   2580

aggctagtgt gcagtggcac aatctcggct cactgcagcc tctgcctcct gggttcaagt   2640

gattctcgtg cctcagcctc ctgagtaact ggaattacag gcatgcacca ccacacctgg   2700

ctgaattttt tgtattttta gtagagatag ggttttgctg tgttggccag gctggtaact   2760

cctggcctca agtgatcttc ctgcctcagc ctcccaaagt gctgggatta caggtgtgag   2820

cccccacacc cagccacaaa tcaatatttt gtatgctttt tctcctaaca acttgtaggc   2880

aggaactgag agtatcccag tttttcagat gaggaaagtg aatcttagaa aagtgtgtta   2940

gtctgctctg gctgctgtaa taaaatacta tagactgcgt ggcttatata gcagaaatgt   3000

gttttctctc aggtctagag gccgcaagtc taaggtcagg gtaccagcat tgttgggttc   3060

tgataagggc tgtcttctca gcttgcagat ggccgccttc tcactttgtg ctcacatggc   3120

cttccctcag tgccttcact tcttacaaga agtttaccat gttggccagg ctggtcttga   3180

actcccgacc ttcagtgatc cgcctgtctt ggccttccaa agtgctggga ttacaggcat   3240

gagccaccat gcctggcccc cctctgactt tcataattgt ccctaggtgt gcagaattag   3300

aaaaattata aataatgatt tatgacacat tgtcatcatt agtcaatgcg tgtcctggtt   3360

ttttgtttta ttttctttca ttgcatttta ttaatatatt tattcatcct cctttaaaaa   3420

gattgtaatg aacacctaca aacctttcgc caagtacaag aacatgacct gcttcctgca   3480

tctgttgatg tgtttctttc ctttcccatt cctatgctgc ctcccttgca tacatggcca   3540

ctttaagatt tgttattcca ttgcttattc tgtaggaaga ttcaggtttt tttcataaat   3600

ataggctatt cagatgttct gtttttgttt gtccgttttg gtaatttgag taatgtaaaa   3660

tatttgccta ctttatcttt gtcttcccat tactttttaa gattgtttca tctcataatg   3720

gtaaattttg tattttatca caataaaaag tcag                               3754


<210>  3532
<211>  95
<212>  PRT
<213>  Homo sapiens

<400>  3532


Met Ala Ala Pro Ala Leu Ala Leu Val Ser Phe Glu Asp Val Val Val 
1               5                   10                  15      


Thr Phe Thr Gly Glu Glu Trp Gly His Leu Asp Leu Ala Gln Arg Thr 
            20                  25                  30          


Leu Tyr Gln Glu Val Met Leu Glu Thr Cys Arg Leu Leu Val Ser Leu 
        35                  40                  45              


Gly His Pro Val Pro Lys Pro Glu Leu Ile Tyr Leu Leu Glu His Gly 
    50                  55                  60                  


Gln Glu Leu Trp Thr Val Lys Arg Gly Leu Ser Gln Ser Thr Cys Ala 
65                  70                  75                  80  


Ala Ser Phe Ser Leu Leu Trp Lys Ser Tyr His Pro Gly His Gly 
                85                  90                  95  

<210>  3533
<211>  1828
<212>  DNA
<213>  Homo sapiens

<400>  3533
atcatattaa ataattatct tcattttcct taggaatctc catctcaagg ctcagagaga     60

tgaactgctg gcgcagggat acacagggag gaaagtcaag gcgtgagttg cctggtagag    120

acatttgaga gtgggtcatt gcctcagata atttccacgg aactctgtgt gcctctcctt    180

taagaagagg tgaagccaat ccctttcttg ggagccttga gaagccgcct caccgagaac    240

agaaagtgcg ctccaggtac cacccggatt ccgtcaaact acattaccca gaaggcagtg    300

ctacaaggga cggaagccga ccccaagcca tagacggaag gcgcagaggg gcgttcccgt    360

agcggcgtgg gcgggacttc cggcgtccag tcttcgtccg ccgttaggtt gcggctgctg    420

tggttgccaa cgctacactg ggtagaacgc cagacagggg ccacttttcg agaccgagta    480

gagacggaca gtgaggagga taggacccac ttacacgctt ttatgtcagc cgcgatccca    540

cccccacaag cgtctgcaaa acccttcctg gggccttggc gacagccctg tgtcctcacg    600

gcgcgcagag gcggcgccgc gaaccttgtg tgcattttac acgacggcgg ggactgaggt    660

ccctcgcagc ccagagccgg agcccggggt cggccgagcc cgcaggaccg gcttcctcgc    720

cgactctcac ggcctcaccc agccccctgg gcccatggcg gcgccggcgt tggtgagtgg    780

agggttccgc agcccgcgcg agctcgggtc accgcccgca tgcacccatc cgctgtaata    840

cggcggatgc cgggactctg tgcttctccc ttttgatgcc ctaggttatg gagatcccgg    900

gagagggtga ggtgagaggg cagggctaat cacttcctac ccagggtcct gaatccagga    960

caggagttgt aaggagaggt ccctgtctct ggctctaacc tggagctgtc gcctcgctgc   1020

cctcggcctc cattccctcg ggtctaaaat gcgagtctca gtaattttct ctgtggaggg   1080

agctggagag ggtacgcttg tgacgtgggt cctgtctttc actgctcgga gagcatcact   1140

ctaggtgccg tctttgaaga aggactctct aggtcctgct gttgttttag gggatcattc   1200

cagcggaagt ctggccctac caaaagctgg gagagggaat gagagcctcg agggcaagag   1260

gcattagtat catttgaaga cgtggttgtg accttcactg gagaggaatg ggggcacctg   1320

gacctggccc agaggaccct gtaccaggag gtgatgctgg agacctgcag gctcctggtc   1380

tcactggggc atcctgttcc caaaccagag ctgatctatc tactggaaca tggacaggaa   1440

ctgtggacag tgaagagagg cctctcccaa agcacctgcg caggttggtg actgagagtc   1500

tggcagcggg tatcagggca gcctgcagac cacccaggca tcactgtgtc tgaaatgcca   1560

tgggcagcta ttttgtggtc ttgagcagtc atggagccct tgaccccatg gtcccccgtc   1620

ttcccacttc tgtcacacac tctttgcctt tattcaggtt ggaatatgtt aggtaggaga   1680

cagattctag gctttaatga tttgccactc actagcctca tgactctgga gaggttgtgt   1740

gacgtcactg tgcctttggt atataagtta ggctgagtta atgaccttct ctgaaaaata   1800

aactccaaaa tcatgtgact caacagat                                      1828


<210>  3534
<211>  81
<212>  PRT
<213>  Homo sapiens

<400>  3534


Met Gly Ala Pro Gly Pro Gly Pro Glu Asp Pro Val Pro Gly Gly Asp 
1               5                   10                  15      


Ala Gly Asp Leu Gln Ala Pro Gly Leu Thr Gly Ala Ser Cys Ser Gln 
            20                  25                  30          


Thr Arg Ala Asp Leu Ser Thr Gly Thr Trp Thr Gly Thr Val Asp Ser 
        35                  40                  45              


Glu Glu Arg Pro Leu Pro Lys His Leu Arg Arg Leu Val Thr Glu Ser 
    50                  55                  60                  


Leu Ala Ala Gly Ile Arg Ala Ala Cys Arg Pro Pro Arg His His Cys 
65                  70                  75                  80  


Val 
    

<210>  3535
<211>  1478
<212>  DNA
<213>  Homo sapiens

<400>  3535
atcatattaa ataattatct tcattttcct taggaatctc catctcaagg ctcagagaga     60

tgaactgctg gcgcagggat acacagggag gaaagtcaag gcgtgagttg cctggtagag    120

acatttgaga gtgggtcatt gcctcagata atttccacgg aactctgtgt gcctctcctt    180

taagaagagg tgaagccaat ccctttcttg ggagccttga gaagccgcct caccgagaac    240

agaaagtgcg ctccaggtac cacccggatt ccgtcaaact acattaccca gaaggcagtg    300

ctacaaggga cggaagccga ccccaagcca tagacggaag gcgcagaggg gcgttcccgt    360

agcggcgtgg gcgggacttc cggcgtccag tcttcgtccg ccgttaggtt gcggctgctg    420

tggttgccaa cgctacactg ggtagaacgc cagacagggg ccacttttcg agaccgagta    480

gagacggaca gtgaggagga taggacccac ttacacgctt ttatgtcagc cgcgatccca    540

cccccacaag cgtctgcaaa acccttcctg gggccttggc gacagccctg tgtcctcacg    600

gcgcgcagag gcggcgccgc gaaccttgtg tgcattttac acgacggcgg ggactgaggt    660

ccctcgcagc ccagagccgg agcccggggt cggccgagcc cgcaggaccg gcttcctcgc    720

cgactctcac ggcctcaccc agccccctgg gcccatggcg gcgccggcgt tgtgctcgga    780

gagcatcact ctaggtgccg tctttgaaga aggactctct aggtcctgct gttgttttag    840

gggatcattc cagcggaagt ctggccctac caaaagctgg gagagggaat gagagcctcg    900

agggcaagag gcattagtat catttgaaga cgtggttgtg accttcactg gagaggaatg    960

ggggcacctg gacctggccc agaggaccct gtaccaggag gtgatgctgg agacctgcag   1020

gctcctggtc tcactggggc atcctgttcc caaaccagag ctgatctatc tactggaaca   1080

tggacaggaa ctgtggacag tgaagagagg cctctcccaa agcacctgcg caggttggtg   1140

actgagagtc tggcagcggg tatcagggca gcctgcagac cacccaggca tcactgtgtc   1200

tgaaatgcca tgggcagcta ttttgtggtc ttgagcagtc atggagccct tgaccccatg   1260

gtcccccgtc ttcccacttc tgtcacacac tctttgcctt tattcaggtt ggaatatgtt   1320

aggtaggaga cagattctag gctttaatga tttgccactc actagcctca tgactctgga   1380

gaggttgtgt gacgtcactg tgcctttggt atataagtta ggctgagtta atgaccttct   1440

ctgaaaaata aactccaaaa tcatgtgact caacagat                           1478


<210>  3536
<211>  81
<212>  PRT
<213>  Homo sapiens

<400>  3536


Met Gly Ala Pro Gly Pro Gly Pro Glu Asp Pro Val Pro Gly Gly Asp 
1               5                   10                  15      


Ala Gly Asp Leu Gln Ala Pro Gly Leu Thr Gly Ala Ser Cys Ser Gln 
            20                  25                  30          


Thr Arg Ala Asp Leu Ser Thr Gly Thr Trp Thr Gly Thr Val Asp Ser 
        35                  40                  45              


Glu Glu Arg Pro Leu Pro Lys His Leu Arg Arg Leu Val Thr Glu Ser 
    50                  55                  60                  


Leu Ala Ala Gly Ile Arg Ala Ala Cys Arg Pro Pro Arg His His Cys 
65                  70                  75                  80  


Val 
    

<210>  3537
<211>  1340
<212>  DNA
<213>  Homo sapiens

<400>  3537
atcatattaa ataattatct tcattttcct taggaatctc catctcaagg ctcagagaga     60

tgaactgctg gcgcagggat acacagggag gaaagtcaag gcgtgagttg cctggtagag    120

acatttgaga gtgggtcatt gcctcagata atttccacgg aactctgtgt gcctctcctt    180

taagaagagg tgaagccaat ccctttcttg ggagccttga gaagccgcct caccgagaac    240

agaaagtgcg ctccaggtac cacccggatt ccgtcaaact acattaccca gaaggcagtg    300

ctacaaggga cggaagccga ccccaagcca tagacggaag gcgcagaggg gcgttcccgt    360

agcggcgtgg gcgggacttc cggcgtccag tcttcgtccg ccgttaggtt gcggctgctg    420

tggttgccaa cgctacactg ggtagaacgc cagacagggg ccacttttcg agaccgagta    480

gagacggaca gtgaggagga taggacccac ttacacgctt ttatgtcagc cgcgatccca    540

cccccacaag cgtctgcaaa acccttcctg gggccttggc gacagccctg tgtcctcacg    600

gcgcgcagag gcggcgccgc gaaccttgtg tgcattttac acgacggcgg ggactgaggt    660

ccctcgcagc ccagagccgg agcccggggt cggccgagcc cgcaggaccg gcttcctcgc    720

cgactctcac ggcctcaccc agccccctgg gcccatggcg gcgccggcgt tggcattagt    780

atcatttgaa gacgtggttg tgaccttcac tggagaggaa tgggggcacc tggacctggc    840

ccagaggacc ctgtaccagg aggtgatgct ggagacctgc aggctcctgg tctcactggg    900

gcatcctgtt cccaaaccag agctgatcta tctactggaa catggacagg aactgtggac    960

agtgaagaga ggcctctccc aaagcacctg cgcaggttgg tgactgagag tctggcagcg   1020

ggtatcaggg cagcctgcag accacccagg catcactgtg tctgaaatgc catgggcagc   1080

tattttgtgg tcttgagcag tcatggagcc cttgacccca tggtcccccg tcttcccact   1140

tctgtcacac actctttgcc tttattcagg ttggaatatg ttaggtagga gacagattct   1200

aggctttaat gatttgccac tcactagcct catgactctg gagaggttgt gtgacgtcac   1260

tgtgcctttg gtatataagt taggctgagt taatgacctt ctctgaaaaa taaactccaa   1320

aatcatgtga ctcaacagat                                               1340


<210>  3538
<211>  82
<212>  PRT
<213>  Homo sapiens

<400>  3538


Met Ala Ala Pro Ala Leu Ala Leu Val Ser Phe Glu Asp Val Val Val 
1               5                   10                  15      


Thr Phe Thr Gly Glu Glu Trp Gly His Leu Asp Leu Ala Gln Arg Thr 
            20                  25                  30          


Leu Tyr Gln Glu Val Met Leu Glu Thr Cys Arg Leu Leu Val Ser Leu 
        35                  40                  45              


Gly His Pro Val Pro Lys Pro Glu Leu Ile Tyr Leu Leu Glu His Gly 
    50                  55                  60                  


Gln Glu Leu Trp Thr Val Lys Arg Gly Leu Ser Gln Ser Thr Cys Ala 
65                  70                  75                  80  


Gly Trp 
        

<210>  3539
<211>  643
<212>  DNA
<213>  Homo sapiens

<400>  3539
ttccggcgtc cagtcttcgt ccgccgttag gttgcggctg ctgtggttgc caacgctaca     60

ctgggtagaa cgccagacag gggccacttt tcgagaccga gtagagacgg acagtgagga    120

ggataggacc cacttacacg cttttatgtc agccgcgatc ccacccccac aagcgtctgc    180

aaaacccttc ctggggcctt ggcgacagcc ctgtgtcctc acggcgcgca gaggcggcgc    240

cgcgaacctt gtgtgcattt tacacgacgg cggggactga ggtccctcgc agcccagagc    300

cggagcccgg ggtcggccga gcccgcagga ccggcttcct cgccgactct cacggcctca    360

cccagccccc tgggcccatg gcggcgccgg cgttgtgctc ggagagcatc actctaggtg    420

ccgtctttga agaaggactc tctaggtcct gctgttgttt taggggatca ttccagcgga    480

agtctggccc taccaaaagc tgggagaggg aatgagagcc tcgagggcaa gaggtgaggc    540

gggagcagca tttttggcag gaggctagaa gacaagaagc tcattggatt tatctttgca    600

gatgccgtct gtttattaca aatgaatctg gcttgccgcc taa                      643


<210>  3540
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  3540


Met Ala Ala Pro Ala Leu Cys Ser Glu Ser Ile Thr Leu Gly Ala Val 
1               5                   10                  15      


Phe Glu Glu Gly Leu Ser Arg Ser Cys Cys Cys Phe Arg Gly Ser Phe 
            20                  25                  30          


Gln Arg Lys Ser Gly Pro Thr Lys Ser Trp Glu Arg Glu 
        35                  40                  45  

<210>  3541
<211>  12544
<212>  DNA
<213>  Homo sapiens

<400>  3541
ggccgcgccg gcgatgcggg gccaccccgc gcccgcccca gtcccggccc cggcccccgc     60

gggaaggggc tgagctgccc gccgccgccc ggatggcgag cctcgccgcg ctcgccctca    120

gcctgctcct gaggctgcag ctgccgccac tgcccggcgc ccgggctcag agcgccgcag    180

gtggctgttc ctttgatgag cactacagca actgtggtta tagtgtggct ctagggacca    240

atgggttcac ctgggagcag attaacacat gggagaaacc aatgctggac caggcagtgc    300

ccacaggatc tttcatgatg gtgaacagct ctgggagagc ctctggccag aaggcccacc    360

ttctcctgcc aaccctgaag gagaatgaca cccactgcat cgacttccat tactacttct    420

ccagccgtga caggtccagc ccaggggcct tgaacgtcta cgtgaaggtg aatggtggcc    480

cccaagggaa ccctgtgtgg aatgtgtccg gggtcgtcac tgagggctgg gtgaaggcag    540

agctcgccat cagcactttc tggccacatt tctatcaggt gatatttgaa tccgtctcat    600

tgaagggtca tcctggctac atcgccgtgg acgaggtccg ggtccttgct catccatgca    660

gaaaagcacc tcattttctg cgactccaaa acgtggaggt gaatgtgggg cagaatgcca    720

catttcagtg cattgctggt gggaagtggt ctcagcatga caagctttgg ctccagcaat    780

ggaatggcag ggacacggcc ctgatggtca cccgtgtggt caaccacagg cgcttctcag    840

ccacagtcag tgtggcagac actgcccagc ggagcgtcag caagtaccgc tgtgtgatcc    900

gctctgatgg tgggtctggt gtgtccaact acgcggagct gatcgtgaaa gagcctccca    960

cgcccattgc tcccccagag ctgctggctg tgggggccac atacctgtgg atcaagccaa   1020

atgccaactc catcatcggg gatggcccca tcatcctgaa ggaagtggaa tatcgcacca   1080

ccacaggcac gtgggcagag acccacatag tcgactctcc caactataag ctgtggcatc   1140

tggaccccga tgttgagtat gagatccgag tgctcctcac acgaccaggt gaggggggta   1200

cgggaccgcc agggcctccc ctcaccacca ggaccaagtg tgcagatccg gtacatggcc   1260

cacagaacgt ggaaatcgta gacatcagag cccggcagct gaccctgcag tgggagccct   1320

tcggctacgc ggtgacccgc tgccatagct acaacctcac cgtgcagtac cagtatgtgt   1380

tcaaccagca gcagtacgag gccgaggagg tcatccagac ctcctcccac tacaccctgc   1440

gaggcctgcg ccccttcatg accatccggc tgcgactctt gctgtctaac cccgagggcc   1500

gaatggagag cgaggagctg gtggtgcaga ctgaggaaga cgttccagga gctgttcctc   1560

tagaatccat ccaagggggg ccctttgagg agaagatcta catccagtgg aaacctccca   1620

atgagaccaa tggggtcatc acgctctacg agatcaacta caaggctgtc ggctcgctgg   1680

acccaagtgc tgacctctcg agccagaggg ggaaagtgtt caagctccgg aatgaaaccc   1740

accacctctt tgtgggtctg tacccaggga ccacctattc cttcaccatc aaggccagca   1800

cagcaaaggg ctttgggccc cctgtcacca ctcggattgc caccaaaatt tcagctccat   1860

ccatgcctga gtacgacaca gacaccccat tgaatgagac agacacgacc atcacagtga   1920

tgctgaaacc cgctcagtcc cggggagctc ctgtcagtgt ttatcagctg gttgtcaagg   1980

aggagcgact tcagaagtca cggagggcag ctgacattat tgagtgcttt tcggtgcccg   2040

tgagctatcg gaatgcctcc agcctcgatt ctctacacta ctttgctgct gagttgaagc   2100

ctgccaacct gcctgtcacc cagccattta cagtgggtga caataagaca tacaatggct   2160

actggaaccc tcctctctct cccctgaaaa gctacagcat ctacttccag gcactcagca   2220

aagccaatgg agagaccaaa atcaactgtg ttcgtctggc tacaaaaggt gcctccaccc   2280

agaattctaa cactgtggag ccagagaagc aggtggacaa caccgtgaag atggctggcg   2340

tgatcgctgg cctcctcatg ttcatcatca ttctcctggg cgtgatgctc accatcaaaa   2400

ggagaagaaa tgcttattcc tactcctatt acttgaagct ggccaagaag cagaaggaga   2460

cccagagtgg agcccagagg gagatggggc ctgtggcctc tgccgacaaa cccaccacca   2520

agctcagcgc cagccgcaat gatgaaggct tctcttctag ttctcaggac gtcaacggat   2580

tcacagatgg cagccgcggg gagctttccc agcccaccct cacgatccag actcatccct   2640

accgcacctg tgaccctgtg gagatgagct acccccggga ccagttccaa cccgccatcc   2700

gggtggctga cttgctgcag cacatcacgc agatgaagag aggccagggc tacgggttca   2760

aggaggaata cgaggcctta ccagaggggc agacagcttc gtgggacaca gccaaggagg   2820

atgaaaaccg caataagaat cgatatggga acatcatatc ctacgaccat tcccgggtga   2880

ggctgctggt gctggatgga gacccgcact ctgactacat caatgccaac tacattgacg   2940

gataccatcg acctcggcac tacattgcga ctcaaggtcc gatgcaggag actgtaaagg   3000

acttttggag aatgatctgg caggagaact ccgccagcat cgtcatggtc acaaacctgg   3060

tggaagtggg cagggtgaaa tgtgtgcgat actggccaga tgacacggag gtctacggag   3120

acattaaagt caccctgatt gaaacagagc ccctggcaga atacgtcata cgcaccttca   3180

cagtccagaa gaaaggctac catgagatcc gggagctccg cctcttccac ttcaccagct   3240

ggcctgacca cggcgttccc tgctatgcca ctggccttct gggcttcgtc cgccaggtca   3300

agttcctcaa ccccccggaa gctgggccca tagtggtcca ctgcagtgct ggggctgggc   3360

ggactggctg cttcattgcc attgacacca tgcttgacat ggccgagaat gaaggggtgg   3420

tggacatctt caactgcgtg cgtgagctcc gggcccaaag ggtcaacctg gtacagacag   3480

aggagcaata tgtgtttgtg cacgatgcca tcctggaagc gtgcctctgt ggcaacactg   3540

ccatccctgt gtgtgagttc cgttctctct actacaatat cagcaggctg gacccccaga   3600

caaactccag ccaaatcaaa gatgaatttc agaccctcaa cattgtgaca ccccgtgtgc   3660

ggcccgagga ctgcagcatt gggctcctgc cccggaacca tgataagaat cgaagtatgg   3720

acgtgctgcc tctggaccgc tgcctgccct tccttatctc agtggacgga gaatccagca   3780

attacatcaa cgcagcactg atggatagcc acaagcagcc tgccgccttc gtggtcaccc   3840

agcaccctct acccaacacc gtggcagact tctggaggct ggtgttcgat tacaactgct   3900

cctctgtggt gatgctgaat gagatggaca ctgcccagtt ctgtatgcag tactggcctg   3960

agaagacctc cgggtgctat gggcccatcc aggtggagtt cgtctccgca gacatcgacg   4020

aggacatcat ccacagaata ttccgcatct gtaacatggc ccggccacag gatggttatc   4080

gtatagtcca gcacctccag tacattggct ggcctgccta ccgggacacg cccccctcca   4140

agcgctctct gctcaaagtg gtccgacgac tggagaagtg gcaggagcag tatgacggga   4200

gggagggacg tactgtggtc cactgcctaa atgggggagg ccgtagtgga accttctgtg   4260

ccatctgcag tgtgtgtgag atgatccagc agcaaaacat cattgacgtg ttccacatcg   4320

tgaaaacact gcgtaacaac aaatccaaca tggtggagac cctggaacag tataaatttg   4380

tatacgaggt ggcactggaa tatttaagct ccttttagct caatgggatg gggaacctgc   4440

cggagtccag aggctgctgt gaccaagccc ccttttgtgt gaatggcagt aactgggctc   4500

aggagctctg aggtggcacc ctgcctgact ccaaggagaa gactggtggc cctgtgttcc   4560

acggggggct ctgcaccttc tgaggggtct cctgttgccg tgggagatgc tgctccaaaa   4620

ggcccaggct tccttttcaa cctaaccagc cacagccaag ggcccaagca gaagtacacc   4680

cacaagcaag gccttggatt tctggctccc agaccacctg cttttgttct gagtttgtgg   4740

atctcttggc aagccaactg tgcaggtgct ggggagtggg aggctcccct gccctccttc   4800

tccttaggag tggaggagat gtgtgttctg ctcctctacg tcatggaaaa gattgaggct   4860

cttgggggtc actgctctgc tgccccctgc aacctccttc aggggcctct ggcaccagac   4920

atttgcagtc tggaccagtg tgaccttacg atgttcccta ggccacaaga gaggcccccc   4980

atcctcacac ctaacctgca tggggcttcg cccacaacca ttctgtaccc cttccccagc   5040

ctgggccttg accgtccagc attcactggc cggccagctg tgtccacagc agtttttgat   5100

aaaggtgttc tttgcttttt tgtgtggtca gtgggagggg gtggaactgc agggaacttc   5160

tctgctcctc cttgtctttg taaaaaggga ccacctccct ggggcagggc ttgggctgac   5220

ctgtaggatg taacccctgt gtttctttgg tggtagcttt ctttggaaga gacaaacaag   5280

ataagatttg attattttcc aaagtgtatg tgaaaagaaa ctttcttttg gagggtgtaa   5340

aatcttagtc tcttatgtca aaaagaaggg ggcgggggag tttgagtatg tacctctaag   5400

acaaatctct cgggcctttt attttttcct ggcaatgtcc ttaaaagctc ccaccctggg   5460

acagcatgcc actgagcaag gagagatggg tgagcctgaa gatggtccct ttggtttctg   5520

gggcaaatag agcaccagct ttgtgcataa tttggatgtc caaatttgaa ctccttccta   5580

aagaaaccca gcagccacct tgaaaaaggc cattgtggag cccattatac tttgatttaa   5640

aataggccaa gagaatcagg cctggagatc tagggtcttg tccaaagtgt gagtgagtca   5700

atgagaggga accaacattt gctaagtctc tactgtatgc cagggatcat gcttggcact   5760

ttccatagga catttcacac agtccttaga acccccagga gagagctact gacttgttat   5820

catctccatt tgatcatctc ctccaatgag gaaacccacg caccttcctt agtaatgaaa   5880

tcctgggttc caaaggggca ggtaatggca atgagacttc tccgtgctgt tttcttcatc   5940

ttctctaagc caagcaatta ttttatggag ggaaaataag gccagaaact tctgagcaga   6000

taactccaca aatggaaatt tagtactttc ttcctgatgc cagttcttct gggaagcgca   6060

gaatttcaga tatattttag taacacattc ccagctcccc aggaaagcca gtctcatcta   6120

atttcttagt cagtaaaaac aattccctgt tccttcaggc tatgaatgga ccagccaggg   6180

aaactctcga ccttgatctc tagccagtgc ttaggcccaa tatctgacag cctcaggtgg   6240

gctgggacct aggaagctcc atcttgaagg ctggtctagc cccagacagg gcatgagggg   6300

cagagaattc aagaaggtac agctttggcc ctcaagagcc cactgtatgc tggggaaatg   6360

gaaccatggt gcagtagtgt ggagtggatg agtgttccat gagcctagga gcaagaaagt   6420

ctcttcggcc tcgggcttcc tggagaaggg gacgtccatt cctgctgggt cttaacaagc   6480

ataaaaagga aaaaaaggaa actcaggcaa agggatccat atgtgcaatg gcaaagaaat   6540

gtgaaaaggc attgggagaa gcagtctggg ggaggccagc ccagtgcggg cacagcacaa   6600

cacggggagc agcaagagat gagccagggt ccaggagaca gatgcccatc gcgagtacag   6660

actttgtcct attggcaaca aggagtccat ggagctttag agagatgcac tcagcttcgt   6720

gttggccaag actccttctg ggccaatggg gctgcctctt ttcctttcat cagacactgt   6780

gaaaacattc ccttaagcgt gcacttttta atatcacatc tatttgtctg tctgctcatt   6840

gttttgttgc tggaactaaa tatgcaatgg atcatgagac tcagattcta tgagaaaccc   6900

agggtctctg ctttaccacg gagcagggtc accaacccag atctccaggc ccatgaggat   6960

ggaacatgaa aggagccgac aaaagttgct tccattggca tgggctctgg agctgtccag   7020

aagtccaggg acaccagact tgatcaagga agggctgtca ctttagaggt tcaaaaggaa   7080

gtgcctcaaa gcaaaggcaa gcaaaggaac cccacgatga acttgctctt ttcctttgat   7140

gagcctctcc ccaggtgtat ttcagcagac cccggggacc cacccccact gggcctgctg   7200

gcctccctcg gctccagccc aatgccccag ctggccttcc ccagcctgca aggagcctgt   7260

agcatggcaa atctgcctgc tgtatgctat tttcttagat cttggtacat ccagacagga   7320

tgagggtgga gggagagcta tttaacacaa atcctaagat ttttttctgc tcaggaaggg   7380

gtgaaatagc tggcagatac aaaagacagt ggcttttatc attttaaatg gtaggaattt   7440

aaggtgtgac ttcagggaga aacaaacttg caaaaaaaaa aaatctcagg ccatgttggg   7500

gtaacccagc aagggccagt gatgatttcc cccagctcat ccccttattt tcccacaacc   7560

caaccattct ctaaagcagg acagtgaata ggtcttaggc cagtgcacac aggaagaaat   7620

tgaggcttat ggatggggat gacttcccta agatcccatg ggacaaggat gtggcaaggc   7680

ttggatgaga tggggcacca gtgcccagga atttgaacat tttcctttac ccaggaaatc   7740

tccggagcca acaccaccac ccccaggggg tctccccacc ccaccccatt tacagggtga   7800

gctcagcctg tcatgagcag aggaaaatat tattaatgct ctctgagtct ttacaacagg   7860

agctcttacc tcatagatgt gggctctgtt tggggaagat gcaaggaagt aatgagaagc   7920

ccaggaaatt tctccacctg tgtttatggc ctaaatagct tcaggatgta tcttagctgc   7980

actccaacat tgcatccttt ctggggtgaa gaatctgggc caaccagggg tccttgggcc   8040

tctagaaggc cacagtaggc ctctctttgt gggaatggaa ggggacagtt tgcttttagt   8100

gctggccctc tctgtgggtg tggcctgcaa aggaaccaac agaccctatg ctggggactc   8160

taacatgtga gctcattaaa ttcttccagc attctaaagg agggtttgtg attgtcacca   8220

tttactgatg aggaaactaa ggctcctagg ggagaaatca cttgcccaca gttccacagc   8280

tagtgagtga atgaaccagg atttaaaccg gttttttctc actacagaga caatattttt   8340

ccaccattgt atctcacatt tttcccagga ggttacccat aacagaagag actagagtgg   8400

aacagatacg tcagtggata aagctcaaag caaacaacag taagcttaaa attccttcat   8460

agtctcatgt tttacgttca caattcatgc aaaatttgca ttccactttc tgatttagcc   8520

ttgttggttt taatatgact ctatgaatat ttcaaaaaaa aatgtgctct gttcctcatg   8580

ttgttctgtt ctgttcaccc cgctatgacg gaccctaggt cagctggtct tcagcttgac   8640

cctagaattg actctaggag cagtgaccct gctgcctccc agagccagtt ataggctcaa   8700

gatcaagacc aactgacctt ctcctaggca gctcctttgg tgtgtgggtg ctctgacctc   8760

actgttcatg aggggacctc aactaaggca tcttccagtt gggtgctgga aggaacccat   8820

taactcacac tagaatgatg aggatttgct catctggcgt ggagaaggat gagcccacaa   8880

aaccctaaag ggaaaagaga agctggacac agctgtactc agcagattcc tgaatgctag   8940

gctggaaagt ggtgcctgtt gtccaagtgg agtcacatgg ttgctaatgt gggcaagtct   9000

gaggacacac ttcatgagca gctggggtct ggaaggctcc tcactttacc ctagccacac   9060

ataattactg ggtgcctaca gcacctagca ccttggaggg ggcactatta ggaaatcgag   9120

attactatgg cacaattaat tcctgggtaa ggcatggggt tgtggtggac agagctcagt   9180

ctttagtttg aacgaaaaca tacatacatg aaaaacatac atgaaaaaag gaccctcatc   9240

aacattagaa ggggtagatt tggagcactt taggcaggaa aacaggaacg caaggccagg   9300

aaactggaac ccagtgaata ctcagaaccg aggatgcaga tgacttattt agcaaaatgg   9360

tcacttctgt gacatagctg gagaaaggat gggtaacagc ttgccagagc cacttggaac   9420

aagggcaaat ctcagtgtct ggggcaaaag atgatgcatt tccctctgac ccatcatgtt   9480

tattcatcct ccactcccca ttgccacact agctcttgct gtaagtcctc accaggatct   9540

acatttcctc gtcgctggtg ggaacccctt agagtacata gaggtatcag tccagtaaga   9600

ctgctctaca caacagaagt gaggcccagg gagtagcagc caggccctta tcctgttacc   9660

tctgcaggag tgactgccca acccagatcc agagacattg aaggaaatga taattccttg   9720

gtacctcact gccttgggac aaaatgaaga aagccaccct tccttaggct gcagcttgcc   9780

actcctgggc tgggtaaaca ggtcatcagc accaagctca accaggagta acactctgga   9840

agacatgggt gagcccaaga ggaagcatga acaggacgct gttcctaagt catgtcaaca   9900

ggttgtgctg ggccaggatc cccagggaaa aaaatggtca acccaactgg agggtaggtt   9960

agaagaaaaa aaacataaac gtggatagtc atgtcatctc aaatccctga cttggcttcc  10020

ccattactta acagtctgag ctccttctta gcctgtgacc agcttcaaat cacagccaag  10080

taaaacaagg aaataggaaa agtaaatcca actagaagag acaagctgag attcagattt  10140

gtttactcct cccatgcaaa gtttccctgt tggaggtttt ccatgtatac atgtctagaa  10200

gtgatagaat gcaaggcctt ggctttgtct tgcagggatc tgcctttgag gtcatagact  10260

gaacagcagg gagagaggtt agtggtggag tgtgggggga gctgttctag ctccagtttc  10320

ttctgacaca tttttcagga tcatggatct gatcctccga agcacagcag agatatctaa  10380

gccatatttg tgcacatgag cagactcttc tagtttttta gtaaccaggg atgggctttt  10440

gcatggcact gactatagag atgtcttgta gagatcaagc cagtcttttg catcccacct  10500

gcccacctcc agaagagatg ggaaaaggtc atcaaagggc attcaccaac tgaaatccac  10560

tcatgaatgt taggtctcta aaaggaggca tcaacactca caatggtagc ctccaaacct  10620

agcatcccac ctatctaaga gctcaggggt ggtccactgg ggcagataca agggaagtgc  10680

aagggctcag gatgaaagaa aatctattgg gaagagtttt aggggcttga tcattatggg  10740

gcttccttct atatctgaga actgctctgg gtggtgagat gtggactctg atccttaatt  10800

ggaatgttcg gagaatgagt gtctggtggc cttgaagtgt tggacagaaa agtatcagta  10860

taaaagcctg gagctcaggg taattaatgt agttcatggt tccttagtga gcaggactct  10920

tggatgtgga ggagaaaggg tcataggaag taaaccacca aaattacaaa attgagtctc  10980

tgtacaatta cttcagtgcc tttgggctta tgaatacaaa tcagtgggcc ttctctatga  11040

tggtccaaca aactctcagt gtccaccctg tccctgtatc tcccatggaa gatgaataat  11100

gtcaggtgtt ctttgggtca aaggccccag ggcagtctgg aggcttagag ggcagagtgg  11160

tgtcattcca tgtaaagtta ggcttctgag gggtcaggca gaatatggtg tccatatctt  11220

ccatagctct gcagattctt ggatgaagtc aagcacagtt tgctagaccc aggtcactcc  11280

tctgagtata actaggaccc atgagtgaaa cttaatagct gtaaggaaga acctgctgtc  11340

tgccagagag gataagctgc ccatctcagc agctgtctaa aagaaggcag gtgtctcttt  11400

aaagggaaga gaagcattgg tgaaatggat ttcaggtcac ttccattcca gatgggtgag  11460

atcttgtgga gctgggatca tgtttgaact cattcatacc tgtagagcac gaatccaagt  11520

agattgtgtt tggtctgtac aggctgaagc cccctgctct cccacccaag tgcccccact  11580

gagcaggcca acatgctgtt gtggccacat atactgggct gatccaggct ggttatcacc  11640

aaacagcaaa ccatagggaa cagctgcttt gccatagacc caatacccat gtagatctct  11700

catgagagca gccataactc agacccactg accaacaggg ccatgagtga cagccagaac  11760

cagtgaaggt ccaagtagga cacagagcag ggcttttctt accatacaca ttatctccag  11820

aggttatttc taccccactc cctattcaag gcctgttgga gcacactgca aaagcaaaag  11880

cacagtaact caatttacac atgattataa tcatttccag tgcacacatt tcatcaccag  11940

gtggatcctg agctagccca tgtaaatccg ggttaaccca tattggtaat catactcaaa  12000

agcacttttc accctacatt ctactagcca atcaaagaca aagagttgtg gcctctacca  12060

ttgccttggc ttctggacac cctcacaagc tatcccaagg ttcccgctca actccaggga  12120

ggctgacatc ttcacatcca ctgggcatat aatattgcat gagaccaaag tctccacact  12180

ctttgcagcc tcctccatga atcccaatgg cctgcacttg tacagtttgg gtgtttgata  12240

gataaagcac gtatgagaag agaaaacaaa ataaatcaac tttttaaaaa agccagcact  12300

gtgctgtcaa tgtttttttt ttcttttcaa ttctagctca gaaaagcaga aggtaaataa  12360

tgtcaggtca atgaatatca gatatatttt ttgactgtac attacagtga agtgtaatct  12420

ttttacacct gcaagtccat cttatttatt cttgtaaatg ttccctgaca atgtttgtaa  12480

catggctgtg ttaaaaaatc tatacaataa agctgtgacc ctgagattca tgttttccta  12540

agat                                                               12544


<210>  3542
<211>  1441
<212>  PRT
<213>  Homo sapiens

<400>  3542


Met Ala Ser Leu Ala Ala Leu Ala Leu Ser Leu Leu Leu Arg Leu Gln 
1               5                   10                  15      


Leu Pro Pro Leu Pro Gly Ala Arg Ala Gln Ser Ala Ala Gly Gly Cys 
            20                  25                  30          


Ser Phe Asp Glu His Tyr Ser Asn Cys Gly Tyr Ser Val Ala Leu Gly 
        35                  40                  45              


Thr Asn Gly Phe Thr Trp Glu Gln Ile Asn Thr Trp Glu Lys Pro Met 
    50                  55                  60                  


Leu Asp Gln Ala Val Pro Thr Gly Ser Phe Met Met Val Asn Ser Ser 
65                  70                  75                  80  


Gly Arg Ala Ser Gly Gln Lys Ala His Leu Leu Leu Pro Thr Leu Lys 
                85                  90                  95      


Glu Asn Asp Thr His Cys Ile Asp Phe His Tyr Tyr Phe Ser Ser Arg 
            100                 105                 110         


Asp Arg Ser Ser Pro Gly Ala Leu Asn Val Tyr Val Lys Val Asn Gly 
        115                 120                 125             


Gly Pro Gln Gly Asn Pro Val Trp Asn Val Ser Gly Val Val Thr Glu 
    130                 135                 140                 


Gly Trp Val Lys Ala Glu Leu Ala Ile Ser Thr Phe Trp Pro His Phe 
145                 150                 155                 160 


Tyr Gln Val Ile Phe Glu Ser Val Ser Leu Lys Gly His Pro Gly Tyr 
                165                 170                 175     


Ile Ala Val Asp Glu Val Arg Val Leu Ala His Pro Cys Arg Lys Ala 
            180                 185                 190         


Pro His Phe Leu Arg Leu Gln Asn Val Glu Val Asn Val Gly Gln Asn 
        195                 200                 205             


Ala Thr Phe Gln Cys Ile Ala Gly Gly Lys Trp Ser Gln His Asp Lys 
    210                 215                 220                 


Leu Trp Leu Gln Gln Trp Asn Gly Arg Asp Thr Ala Leu Met Val Thr 
225                 230                 235                 240 


Arg Val Val Asn His Arg Arg Phe Ser Ala Thr Val Ser Val Ala Asp 
                245                 250                 255     


Thr Ala Gln Arg Ser Val Ser Lys Tyr Arg Cys Val Ile Arg Ser Asp 
            260                 265                 270         


Gly Gly Ser Gly Val Ser Asn Tyr Ala Glu Leu Ile Val Lys Glu Pro 
        275                 280                 285             


Pro Thr Pro Ile Ala Pro Pro Glu Leu Leu Ala Val Gly Ala Thr Tyr 
    290                 295                 300                 


Leu Trp Ile Lys Pro Asn Ala Asn Ser Ile Ile Gly Asp Gly Pro Ile 
305                 310                 315                 320 


Ile Leu Lys Glu Val Glu Tyr Arg Thr Thr Thr Gly Thr Trp Ala Glu 
                325                 330                 335     


Thr His Ile Val Asp Ser Pro Asn Tyr Lys Leu Trp His Leu Asp Pro 
            340                 345                 350         


Asp Val Glu Tyr Glu Ile Arg Val Leu Leu Thr Arg Pro Gly Glu Gly 
        355                 360                 365             


Gly Thr Gly Pro Pro Gly Pro Pro Leu Thr Thr Arg Thr Lys Cys Ala 
    370                 375                 380                 


Asp Pro Val His Gly Pro Gln Asn Val Glu Ile Val Asp Ile Arg Ala 
385                 390                 395                 400 


Arg Gln Leu Thr Leu Gln Trp Glu Pro Phe Gly Tyr Ala Val Thr Arg 
                405                 410                 415     


Cys His Ser Tyr Asn Leu Thr Val Gln Tyr Gln Tyr Val Phe Asn Gln 
            420                 425                 430         


Gln Gln Tyr Glu Ala Glu Glu Val Ile Gln Thr Ser Ser His Tyr Thr 
        435                 440                 445             


Leu Arg Gly Leu Arg Pro Phe Met Thr Ile Arg Leu Arg Leu Leu Leu 
    450                 455                 460                 


Ser Asn Pro Glu Gly Arg Met Glu Ser Glu Glu Leu Val Val Gln Thr 
465                 470                 475                 480 


Glu Glu Asp Val Pro Gly Ala Val Pro Leu Glu Ser Ile Gln Gly Gly 
                485                 490                 495     


Pro Phe Glu Glu Lys Ile Tyr Ile Gln Trp Lys Pro Pro Asn Glu Thr 
            500                 505                 510         


Asn Gly Val Ile Thr Leu Tyr Glu Ile Asn Tyr Lys Ala Val Gly Ser 
        515                 520                 525             


Leu Asp Pro Ser Ala Asp Leu Ser Ser Gln Arg Gly Lys Val Phe Lys 
    530                 535                 540                 


Leu Arg Asn Glu Thr His His Leu Phe Val Gly Leu Tyr Pro Gly Thr 
545                 550                 555                 560 


Thr Tyr Ser Phe Thr Ile Lys Ala Ser Thr Ala Lys Gly Phe Gly Pro 
                565                 570                 575     


Pro Val Thr Thr Arg Ile Ala Thr Lys Ile Ser Ala Pro Ser Met Pro 
            580                 585                 590         


Glu Tyr Asp Thr Asp Thr Pro Leu Asn Glu Thr Asp Thr Thr Ile Thr 
        595                 600                 605             


Val Met Leu Lys Pro Ala Gln Ser Arg Gly Ala Pro Val Ser Val Tyr 
    610                 615                 620                 


Gln Leu Val Val Lys Glu Glu Arg Leu Gln Lys Ser Arg Arg Ala Ala 
625                 630                 635                 640 


Asp Ile Ile Glu Cys Phe Ser Val Pro Val Ser Tyr Arg Asn Ala Ser 
                645                 650                 655     


Ser Leu Asp Ser Leu His Tyr Phe Ala Ala Glu Leu Lys Pro Ala Asn 
            660                 665                 670         


Leu Pro Val Thr Gln Pro Phe Thr Val Gly Asp Asn Lys Thr Tyr Asn 
        675                 680                 685             


Gly Tyr Trp Asn Pro Pro Leu Ser Pro Leu Lys Ser Tyr Ser Ile Tyr 
    690                 695                 700                 


Phe Gln Ala Leu Ser Lys Ala Asn Gly Glu Thr Lys Ile Asn Cys Val 
705                 710                 715                 720 


Arg Leu Ala Thr Lys Gly Ala Ser Thr Gln Asn Ser Asn Thr Val Glu 
                725                 730                 735     


Pro Glu Lys Gln Val Asp Asn Thr Val Lys Met Ala Gly Val Ile Ala 
            740                 745                 750         


Gly Leu Leu Met Phe Ile Ile Ile Leu Leu Gly Val Met Leu Thr Ile 
        755                 760                 765             


Lys Arg Arg Arg Asn Ala Tyr Ser Tyr Ser Tyr Tyr Leu Lys Leu Ala 
    770                 775                 780                 


Lys Lys Gln Lys Glu Thr Gln Ser Gly Ala Gln Arg Glu Met Gly Pro 
785                 790                 795                 800 


Val Ala Ser Ala Asp Lys Pro Thr Thr Lys Leu Ser Ala Ser Arg Asn 
                805                 810                 815     


Asp Glu Gly Phe Ser Ser Ser Ser Gln Asp Val Asn Gly Phe Thr Asp 
            820                 825                 830         


Gly Ser Arg Gly Glu Leu Ser Gln Pro Thr Leu Thr Ile Gln Thr His 
        835                 840                 845             


Pro Tyr Arg Thr Cys Asp Pro Val Glu Met Ser Tyr Pro Arg Asp Gln 
    850                 855                 860                 


Phe Gln Pro Ala Ile Arg Val Ala Asp Leu Leu Gln His Ile Thr Gln 
865                 870                 875                 880 


Met Lys Arg Gly Gln Gly Tyr Gly Phe Lys Glu Glu Tyr Glu Ala Leu 
                885                 890                 895     


Pro Glu Gly Gln Thr Ala Ser Trp Asp Thr Ala Lys Glu Asp Glu Asn 
            900                 905                 910         


Arg Asn Lys Asn Arg Tyr Gly Asn Ile Ile Ser Tyr Asp His Ser Arg 
        915                 920                 925             


Val Arg Leu Leu Val Leu Asp Gly Asp Pro His Ser Asp Tyr Ile Asn 
    930                 935                 940                 


Ala Asn Tyr Ile Asp Gly Tyr His Arg Pro Arg His Tyr Ile Ala Thr 
945                 950                 955                 960 


Gln Gly Pro Met Gln Glu Thr Val Lys Asp Phe Trp Arg Met Ile Trp 
                965                 970                 975     


Gln Glu Asn Ser Ala Ser Ile Val Met Val Thr Asn Leu Val Glu Val 
            980                 985                 990         


Gly Arg Val Lys Cys Val Arg Tyr  Trp Pro Asp Asp Thr  Glu Val Tyr 
        995                 1000                 1005             


Gly Asp  Ile Lys Val Thr Leu  Ile Glu Thr Glu Pro  Leu Ala Glu 
    1010                 1015                 1020             


Tyr Val  Ile Arg Thr Phe Thr  Val Gln Lys Lys Gly  Tyr His Glu 
    1025                 1030                 1035             


Ile Arg  Glu Leu Arg Leu Phe  His Phe Thr Ser Trp  Pro Asp His 
    1040                 1045                 1050             


Gly Val  Pro Cys Tyr Ala Thr  Gly Leu Leu Gly Phe  Val Arg Gln 
    1055                 1060                 1065             


Val Lys  Phe Leu Asn Pro Pro  Glu Ala Gly Pro Ile  Val Val His 
    1070                 1075                 1080             


Cys Ser  Ala Gly Ala Gly Arg  Thr Gly Cys Phe Ile  Ala Ile Asp 
    1085                 1090                 1095             


Thr Met  Leu Asp Met Ala Glu  Asn Glu Gly Val Val  Asp Ile Phe 
    1100                 1105                 1110             


Asn Cys  Val Arg Glu Leu Arg  Ala Gln Arg Val Asn  Leu Val Gln 
    1115                 1120                 1125             


Thr Glu  Glu Gln Tyr Val Phe  Val His Asp Ala Ile  Leu Glu Ala 
    1130                 1135                 1140             


Cys Leu  Cys Gly Asn Thr Ala  Ile Pro Val Cys Glu  Phe Arg Ser 
    1145                 1150                 1155             


Leu Tyr  Tyr Asn Ile Ser Arg  Leu Asp Pro Gln Thr  Asn Ser Ser 
    1160                 1165                 1170             


Gln Ile  Lys Asp Glu Phe Gln  Thr Leu Asn Ile Val  Thr Pro Arg 
    1175                 1180                 1185             


Val Arg  Pro Glu Asp Cys Ser  Ile Gly Leu Leu Pro  Arg Asn His 
    1190                 1195                 1200             


Asp Lys  Asn Arg Ser Met Asp  Val Leu Pro Leu Asp  Arg Cys Leu 
    1205                 1210                 1215             


Pro Phe  Leu Ile Ser Val Asp  Gly Glu Ser Ser Asn  Tyr Ile Asn 
    1220                 1225                 1230             


Ala Ala  Leu Met Asp Ser His  Lys Gln Pro Ala Ala  Phe Val Val 
    1235                 1240                 1245             


Thr Gln  His Pro Leu Pro Asn  Thr Val Ala Asp Phe  Trp Arg Leu 
    1250                 1255                 1260             


Val Phe  Asp Tyr Asn Cys Ser  Ser Val Val Met Leu  Asn Glu Met 
    1265                 1270                 1275             


Asp Thr  Ala Gln Phe Cys Met  Gln Tyr Trp Pro Glu  Lys Thr Ser 
    1280                 1285                 1290             


Gly Cys  Tyr Gly Pro Ile Gln  Val Glu Phe Val Ser  Ala Asp Ile 
    1295                 1300                 1305             


Asp Glu  Asp Ile Ile His Arg  Ile Phe Arg Ile Cys  Asn Met Ala 
    1310                 1315                 1320             


Arg Pro  Gln Asp Gly Tyr Arg  Ile Val Gln His Leu  Gln Tyr Ile 
    1325                 1330                 1335             


Gly Trp  Pro Ala Tyr Arg Asp  Thr Pro Pro Ser Lys  Arg Ser Leu 
    1340                 1345                 1350             


Leu Lys  Val Val Arg Arg Leu  Glu Lys Trp Gln Glu  Gln Tyr Asp 
    1355                 1360                 1365             


Gly Arg  Glu Gly Arg Thr Val  Val His Cys Leu Asn  Gly Gly Gly 
    1370                 1375                 1380             


Arg Ser  Gly Thr Phe Cys Ala  Ile Cys Ser Val Cys  Glu Met Ile 
    1385                 1390                 1395             


Gln Gln  Gln Asn Ile Ile Asp  Val Phe His Ile Val  Lys Thr Leu 
    1400                 1405                 1410             


Arg Asn  Asn Lys Ser Asn Met  Val Glu Thr Leu Glu  Gln Tyr Lys 
    1415                 1420                 1425             


Phe Val  Tyr Glu Val Ala Leu  Glu Tyr Leu Ser Ser  Phe 
    1430                 1435                 1440     

<210>  3543
<211>  11920
<212>  DNA
<213>  Homo sapiens

<400>  3543
cctcccgcct cagttcgcgc cgcgcctcgg cttggaacgc aggagcgccg gctccgggag     60

cccgagcgga gccagccgcg cgcacagcca gcggccgcgc cggcgatgcg gggccacccc    120

gcgcccgccc cagtcccggc cccggccccc gcgggaaggg gctgagctgc ccgccgccgc    180

ccggatggcg agcctcgccg cgctcgccct cagcctgctc ctgaggctgc agctgccgcc    240

actgcccggc gcccgggctc agagcgccgc aggtggctgt tcctttgatg agcactacag    300

caactgtggt tatagtgtgg ctctagggac caatgggttc acctgggagc agattaacac    360

atgggagaaa ccaatgctgg accaggcagt gcccacagga tctttcatga tggtgaacag    420

ctctgggaga gcctctggcc agaaggccca ccttctcctg ccaaccctga aggagaatga    480

cacccactgc atcgacttcc attactactt ctccagccgt gacaggtcca gcccaggggc    540

cttgaacgtc tacgtgaagg tgaatggtgg cccccaaggg aaccctgtgt ggaatgtgtc    600

cggggtcgtc actgagggct gggtgaaggc agagctcgcc atcagcactt tctggccaca    660

tttctatcag gtgatatttg aatccgtctc attgaagggt catcctggct acatcgccgt    720

ggacgaggtc cgggtccttg ctcatccatg cagaaaagca cctcattttc tgcgactcca    780

aaacgtggag gtgaatgtgg ggcagaatgc cacatttcag tgcattgctg gtgggaagtg    840

gtctcagcat gacaagcttt ggctccagca atggaatggc agggacacgg ccctgatggt    900

cacccgtgtg gtcaaccaca ggcgcttctc agccacagtc agtgtggcag acactgccca    960

gcggagcgtc agcaagtacc gctgtgtgat ccgctctgat ggtgggtctg gtgtgtccaa   1020

ctacgcggag ctgatcgtga aagagcctcc cacgcccatt gctcccccag agctgctggc   1080

tgtgggggcc acatacctgt ggatcaagcc aaatgccaac tccatcatcg gggatggccc   1140

catcatcctg aaggaagtgg aatatcgcac caccacaggc acgtgggcag agacccacat   1200

agtcgactct cccaactata agctgtggca tctggacccc gatgttgagt atgagatccg   1260

agtgctcctc acacgaccag gtgagggggg tacgggaccg ccagggcctc ccctcaccac   1320

caggaccaag tgtgcagatc cggtacatgg cccacagaac gtggaaatcg tagacatcag   1380

agcccggcag ctgaccctgc agtgggagcc cttcggctac gcggtgaccc gctgccatag   1440

ctacaacctc accgtgcagt accagtatgt gttcaaccag cagcagtacg aggccgagga   1500

ggtcatccag acctcctccc actacaccct gcgaggcctg cgccccttca tgaccatccg   1560

gctgcgactc ttgctgtcta accccgaggg ccgaatggag agcgaggagc tggtggtgca   1620

gactgaggaa gacgttccag gagctgttcc tctagaatcc atccaagggg ggccctttga   1680

ggagaagatc tacatccagt ggaaacctcc caatgagacc aatggggtca tcacgctcta   1740

cgagatcaac tacaaggctg tcggctcgct ggacccaagt gctgacctct cgagccagag   1800

ggggaaagtg ttcaagctcc ggaatgaaac ccaccacctc tttgtgggtc tgtacccagg   1860

gaccacctat tccttcacca tcaaggccag cacagcaaag ggctttgggc cccctgtcac   1920

cactcggatt gccaccaaaa tttcagctcc atccatgcct gagtacgaca cagacacccc   1980

attgaatgag acagacacga ccatcacagt gatgctgaaa cccgctcagt cccggggagc   2040

tcctgtcagt gtttatcagc tggttgtcaa ggaggagcga cttcagaagt cacggagggc   2100

agctgacatt attgagtgct tttcggtgcc cgtgagctat cggaatgcct ccagcctcga   2160

ttctctacac tactttgctg ctgagttgaa gcctgccaac ctgcctgtca cccagccatt   2220

tacagtgggt gacaataaga catacaatgg ctactggaac cctcctctct ctcccctgaa   2280

aagctacagc atctacttcc aggcactcag caaagccaat ggagagacca aaatcaactg   2340

tgttcgtctg gctacaaaag gtgcctccac ccagaattct aacactgtgg agccagagaa   2400

gcaggtggac aacaccgtga agatggctgg cgtgatcgct ggcctcctca tgttcatcat   2460

cattctcctg ggcgtgatgc tcaccatcaa aaggagaaga aatgcttatt cctactccta   2520

ttacttgaag ctggccaaga agcagaagga gacccagagt ggagcccaga gggagatggg   2580

gcctgtggcc tctgccgaca aacccaccac caagctcagc gccagccgca atgatgaagg   2640

cttctcttct agttctcagg acgtcaacgg attcacagat ggcagccgcg gggagctttc   2700

ccagcccacc ctcacgatcc agactcatcc ctaccgcacc tgtgaccctg tggagatgag   2760

ctacccccgg gaccagttcc aacccgccat ccgggtggct gacttgctgc agcacatcac   2820

gcagatgaag agaggccagg gctacgggtt caaggaggaa tacgaggcct taccagaggg   2880

gcagacagct tcgtgggaca cagccaagga ggatgaaaac cgcaataaga atcgatatgg   2940

gaacatcata tcctacgacc attcccgggt gaggctgctg gtgctggatg gagacccgca   3000

ctctgactac atcaatgcca actacattga cggataccat cgacctcggc actacattgc   3060

gactcaaggt ccgatgcagg agactgtaaa ggacttttgg agaatgatct ggcaggagaa   3120

ctccgccagc atcgtcatgg tcacaaacct ggtggaagtg ggcagggtga aatgtgtgcg   3180

atactggcca gatgacacgg aggtctacgg agacattaaa gtcaccctga ttgaaacaga   3240

gcccctggca gaatacgtca tacgcacctt cacagtccag aagaaaggct accatgagat   3300

ccgggagctc cgcctcttcc acttcaccag ctggcctgac cacggcgttc cctgctatgc   3360

cactggcctt ctgggcttcg tccgccaggt caagttcctc aaccccccgg aagctgggcc   3420

catagtggtc cactgcagtg ctggggctgg gcggactggc tgcttcattg ccattgacac   3480

catgcttgac atggccgaga atgaaggggt ggtggacatc ttcaactgcg tgcgtgagct   3540

ccgggcccaa agggtcaacc tggtacagac agaggagcaa tatgtgtttg tgcacgatgc   3600

catcctggaa gcgtgcctct gtggcaacac tgccatccct gtgtgtgagt tccgttctct   3660

ctactacaat atcagcaggc tggaccccca gacaaactcc agccaaatca aagatgaatt   3720

tcagaccctc aacattgtga caccccgtgt gcggcccgag gactgcagca ttgggctcct   3780

gccccggaac catgataaga atcgaagtat ggacgtgctg cctctggacc gctgcctgcc   3840

cttccttatc tcagtggacg gagaatccag caattacatc aacgcagcac tgatggatag   3900

ccacaagcag cctgccgcct tcgtggtcac ccagcaccct ctacccaaca ccgtggcaga   3960

cttctggagg ctggtgttcg attacaactg ctcctctgtg gtgatgctga atgagatgga   4020

cactgcccag ttctgtatgc agtactggcc tgagaagacc tccgggtgct atgggcccat   4080

ccaggtggag ttcgtctccg cagacatcga cgaggacatc atccacagaa tattccgcat   4140

ctgtaacatg gcccggccac aggatggtta tcgtatagtc cagcacctcc agtacattgg   4200

ctggcctgcc taccgggaca cgcccccctc caagcgctct ctgctcaaag tggtccgacg   4260

actggagaag tggcaggagc agtatgacgg gagggaggga cgtactgtgg tccactgcct   4320

aaatggggga ggccgtagtg gaaccttctg tgccatctgc agtgtgtgtg agatgatcca   4380

gcagcaaaac atcattgacg tgttccacat cgtgaaaaca ctgcgtaaca acaaatccaa   4440

catggtggag accctggaac agtataaatt tgtatacgag gtggcactgg aatatttaag   4500

ctccttttag ctcaatggga tggggaacct gccggagtcc agaggctgct gtgaccaagc   4560

ccccttttgt gtgaatggca gtaactgggc tcaggagctc tgaggtggca ccctgcctga   4620

ctccaaggag aagactggtg gccctgtgtt ccacgggggg ctctgcacct tctgaggggt   4680

ctcctgttgc cgtgggagat gctgctccaa aaggcccagg cttccttttc aacctaacca   4740

gccacagcca agggcccaag cagaagtaca cccacaagca aggccttgga tttctggctc   4800

ccagaccacc tgcttttgtt ctgagtttgt ggatctcttg gcaagccaac tgtgcaggtg   4860

ctggggagtg ggaggctccc ctgccctcct tctccttagg agtggaggag atgtgtgttc   4920

tgctcctcta cgtcatggaa aagattgagg ctcttggggg tcactgctct gctgccccct   4980

gcaacctcct tcaggggcct ctggcaccag acatttgcag tctggaccag tgtgacctta   5040

cgatgttccc taggccacaa gagaggcccc ccatcctcac acctaacctg catggggctt   5100

cgcccacaac cattctgtac cccttcccca gcctgggcct tgaccgtcca gcattcactg   5160

gccggccagc tgtgtccaca gcagtttttg ataaaggtgt tctttgcttt tttgtgtggt   5220

cagtgggagg gggtggaact gcagggaact tctctgctcc tccttgtctt tgtaaaaagg   5280

gaccacctcc ctggggcagg gcttgggctg acctgtagga tgtaacccct gtgtttcttt   5340

ggtggtagct ttctttggaa gagacaaaca agataagatt tgattatttt ccaaagtgta   5400

tgtgaaaaga aactttcttt tggagggtgt aaaatcttag tctcttatgt caaaaagaag   5460

ggggcggggg agtttgagta tgtacctcta agacaaatct ctcgggcctt ttattttttc   5520

ctggcaatgt ccttaaaagc tcccaccctg ggacagcatg ccactgagca aggagagatg   5580

ggtgagcctg aagatggtcc ctttggtttc tggggcaaat agagcaccag ctttgtgcat   5640

aatttggatg tccaaatttg aactccttcc taaagaaacc cagcagccac cttgaaaaag   5700

gccattgtgg agcccattat actttgattt aaaataggcc aagagaatca ggcctggaga   5760

tctagggtct tgtccaaagt gtgagtgagt caatgagagg gcttccttag taatgaaatc   5820

ctgggttcca aaggggcagg taatggcaat gagacttctc cgtgctgttt tcttcatctt   5880

ctctaagcca agcaattatt ttatggaggg aaaataaggc cagaaacttc tgagcagata   5940

actccacaaa tggaaattta gtactttctt cctgatgcca gttcttctgg gaagcgcaga   6000

atttcagata tattttagta acacattccc agctccccag gaaagccagt ctcatctaat   6060

ttcttagtca gtaaaaacaa ttccctgttc cttcaggcta tgaatggacc agccagggaa   6120

actctcgacc ttgatctcta gccagtgctt aggcccaata tctgacagcc tcaggtgggc   6180

tgggacctag gaagctccat cttgaaggct ggtctagccc cagacagggc atgaggggca   6240

gagaattcaa gaaggtacag ctttggccct caagagccca ctgtatgctg gggaaatgga   6300

accatggtgc agtagtgtgg agtggatgag tgttccatga gcctaggagc aagaaagtct   6360

cttcggcctc ggcccatcgc gagtacagac tttgtcctat tggcaacaag gagtccatgg   6420

agctttagag agatgcactc agcttcgtgt tggccaagac tccttctggg ccaatggggc   6480

tgcctctttt cctttcatca gacactgtga aaacattccc ttaagcgtgc actttttaat   6540

atcacatcta tttgtctgtc tgctcattgt tttgttgctg gaactaaata tgcaatggat   6600

catgagactc agattctatg agaaacccag ggtctctgct ttaccacgga gcagggtcac   6660

caacccagat ctccaggccc atgaggatgg aacatgaaag gagccgacaa aagttgcttc   6720

cattggcatg ggctctggag ctgtccagaa gtccagggac accagacttg atcaaggaag   6780

ggctgtcact ttagaggttc aaaaggaagt gcctcaaagc aaaggcaagc aaaggaaccc   6840

cacgatgaac ttgctctttt cctttgatga gcctctcccc aggtgtattt cagcagaccc   6900

cggggaccca cccccactgg gcctgctggc ctccctcggc tccagcccaa tgccccagct   6960

ggccttcccc agcctgcaag gagcctgtag catggcaaat ctgcctgctg tatgctattt   7020

tcttagatct tggtacatcc agacaggatg agggtggagg gagagctatt taacacaaat   7080

cctaagattt ttttctgctc aggaaggggt gaaatagctg gcagatacaa aagacagtgg   7140

cttttatcat tttaaatggt aggaatttaa ggtgtgactt cagggagaaa caaacttgca   7200

aaaaaaaaaa atctcaggcc atgttggggt aacccagcaa gggccagtga tgatttcccc   7260

cagctcatcc ctggggcacc agtgcccagg aatttgaaca ttttccttta cccaggaaat   7320

ctccggagcc aacaccacca cccccagggg gtctccccac cccaccccat ttacagggtg   7380

agctcagcct gtcatgagca gaggaaaata ttattaatgc tctctgagtc tttacaacag   7440

gagctcttac ctcatagatg tgggctctgt ttggggaaga tgcaaggaag taatgagaag   7500

cccaggaaat ttctccacct gtgtttatgg cctaaatagc ttcaggatgt atcttagctg   7560

cactccaaca ttgcatcctt tctggggtga agaatctggg ccaaccaggg gtccttgggc   7620

ctctagaagg ccacagtagg cctctctttg tgggaatgga aggggacagt ttgcttttag   7680

tgctggccct ctctgtgggt gtggcctgca aaggaaccaa cattgtatct cacatttttc   7740

ccaggaggtt acccataaca gaagagacta gagtggaaca gatacgtcag tggataaagc   7800

tcaaagcaaa caacagtaag cttaaaattc cttcatagtc tcatgtttta cgttcacaat   7860

tcatgcaaaa tttgcattcc actttctgat ttagccttgt tggttttaat atgactctat   7920

gaatatttca aaaaaaaatg tgctctgttc ctcatgttgt tctgttctgt tcaccccgct   7980

atgacggacc ctaggtcagc tggtcttcag cttgacccta gaattgactc taggagcagt   8040

gaccctgctg cctcccagag ccagttatag gctcaagatc aagaccaact gaccttctcc   8100

taggcagctc ctttggtgtg tgggtgctct gacctcactg ttcatgaggg gacctcaact   8160

aaggcatctt ccagttgggt gctggaagga acccattaac tcacactaga atgatgagga   8220

tttgctcatc tggcgtggag aaggatgagc ccacaaaacc ctaaagggaa aagagaagct   8280

ggacacagct gtactcagca gattcctgaa tgctaggctg gaaagtggtg cctgttgtcc   8340

aagtggagtc acatggttgc taatgtgggc aagtctgagg acacacttca tgagcagctg   8400

gggtctggaa ggctcctcac tttaccctag ccacacataa ttactgggtg cctacagcac   8460

ctagcacctt ggagggggca ctattaggaa atcgagatta ctatggcaca attaattcct   8520

gggtaaggca tggggttgtg gtggacagag ctcagtcttt agtttgaacg aaaacataca   8580

tacatgaaaa acatacatga aaaaaggacc ctcatcaaca ttagaagggg tagatttgga   8640

gcactttagg caggaaaaca ggaacgcaag gccaggaaac tggaacccag tgaatactca   8700

gaaccgagga tgcagatgac ttatttagca aaatggtcac ttctgtgaca tagctggaga   8760

aaggatgggt aacagcttgc cagagccact tggaacaagg gcaaatctca gtgtctgggg   8820

caaaagatga tgcatttccc tctgacccat catgtttatt catcctccac tccccattgc   8880

cacactagct cttgctgtaa gtcctcacca ggatctacat ttcctcgtcg ctggtgggaa   8940

ccccttagag tacatagagg tatcagtcca gtaagactgc tctacacaac agaagtgagg   9000

cccagggagt agcagccagg cccttatcct gttacctctg caggagtgac tgcccaaccc   9060

agatccagag acattgaagg aaatgataat tccttggtac ctcactgcct tgggacaaaa   9120

tgaagaaagc cacccttcct taggctgcag cttgccactc ctgggctggg taaacaggtc   9180

atcagcacca agctcaacca ggagtaacac tctggaagac atgggtgagc ccaagaggaa   9240

gcatgaacag gacgctgttc ctaagtcatg tcaacaggtt gtgctgggcc aggatcccca   9300

gggaaaaaaa tggtcaaccc aactggaggg taggttagaa gaaaaaaaac ataaacgtgg   9360

atagtcatgt catctcaaat ccctgacttg gcttccccat tacttaacag tctgagctcc   9420

ttcttagcct gtgaccagct tcaaatcaca gccaagtaaa acaaggaaat aggaaaagta   9480

aatccaacta gaagagacaa gctgagattc agatttgttt actcctccca tgcaaagttt   9540

ccctgttgga ggttttccat gtatacatgt ctagaagtga tagaatgcaa ggccttggct   9600

ttgtcttgca gggatctgcc tttgaggtca tagactgaac agcagggaga gaggttagtg   9660

gtggagtgtg gggggagctg ttctagctcc agtttcttct gacacatttt tcaggatcat   9720

ggatctgatc ctccgaagca cagcagagat atctaagcca tatttgtgca catgagcaga   9780

ctcttctagt tttttagtaa ccagggatgg gcttttgcat ggcactgact atagagatgt   9840

cttgtagaga tcaagccagt cttttgcatc ccacctgccc acctccagaa gagatgggaa   9900

aaggtcatca aagggcattc accaactgaa atccactcat gaatgttagg tctctaaaag   9960

gaggcatcaa cactcacaat ggtagcctcc aaacctagca tcccacctat ctaagagctc  10020

aggggtggtc cactggggca gatacaaggg aagtgcaagg gctcaggatg aaagaaaatc  10080

tattgggaag agttttaggg gcttgatcat tatggggctt ccttctatat ctgagaactg  10140

ctctgggtgg tgagatgtgg actctgatcc ttaattggaa tgttcggaga atgagtgtct  10200

ggtggccttg aagtgttgga cagaaaagta tcagtataaa agcctggagc tcagggtaat  10260

taatgtagtt catggttcct tagtgagcag gactcttgga tgtggaggag aaagggtcat  10320

aggaagtaaa ccaccaaaat tacaaaattg agtctctgta caattacttc agtgcctttg  10380

ggcttatgaa tacaaatcag tgggccttct ctatgatggt ccaacaaact ctcagtgtcc  10440

accctgtccc tgtatctccc atggaagatg aataatgtca ggtgttcttt gggtcaaagg  10500

ccccagggca gtctggaggc ttagagggca gagtggtgtc attccatgta aagttaggct  10560

tctgaggggt caggcagaat atggtgtcca tatcttccat agctctgcag attcttggat  10620

gaagtcaagc acagtttgct agacccaggt cactcctctg agtataacta ggacccatga  10680

gtgaaactta atagctgtaa ggaagaacct gctgtctgcc agagaggata agctgcccat  10740

ctcagcagct gtctaaaaga aggcaggtgt ctctttaaag ggaagagaag cattggtgaa  10800

atggatttca ggtcacttcc attccagatg ggtgagatct tgtggagctg ggatcatgtt  10860

tgaactcatt catacctgta gagcacgaat ccaagtagat tgtgtttggt ctgtacaggc  10920

tgaagccccc tgctctccca cccaagtgcc cccactgagc aggccaacat gctgttgtgg  10980

ccacatatac tgggctgatc caggctggtt atcaccaaac agcaaaccat agggaacagc  11040

tgctttgcca tagacccaat acccatgtag atctctcatg agagcagcca taactcagac  11100

ccactgacca acagggccat gagtgacagc cagaaccagt gaaggtccaa gtaggacaca  11160

gagcagggct tttcttacca tacacattat ctccagaggt tatttctacc ccactcccta  11220

ttcaaggcct gttggagcac actgcaaaag caaaagcaca gtaactcaat ttacacatga  11280

ttataatcat ttccagtgca cacatttcat caccaggtgg atcctgagct agcccatgta  11340

aatccgggtt aacccatatt ggtaatcata ctcaaaagca cttttcaccc tacattctac  11400

tagccaatca aagacaaaga gttgtggcct ctaccattgc cttggcttct ggacaccctc  11460

acaagctatc ccaaggttcc cgctcaactc cagggaggct gacatcttca catccactgg  11520

gcatataata ttgcatgaga ccaaagtctc cacactcttt gcagcctcct ccatgaatcc  11580

caatggcctg cacttgtaca gtttgggtgt ttgatagata aagcacgtat gagaagagaa  11640

aacaaaataa atcaactttt taaaaaagcc agcactgtgc tgtcaatgtt ttttttttct  11700

tttcaattct agctcagaaa agcagaaggt aaataatgtc aggtcaatga atatcagata  11760

tattttttga ctgtacatta cagtgaagtg taatcttttt acacctgcaa gtccatctta  11820

tttattcttg taaatgttcc ctgacaatgt ttgtaacatg gctgtgttaa aaaatctata  11880

caataaagct gtgaccctga gattcatgtt ttcctaagat                        11920


<210>  3544
<211>  1441
<212>  PRT
<213>  Homo sapiens

<400>  3544


Met Ala Ser Leu Ala Ala Leu Ala Leu Ser Leu Leu Leu Arg Leu Gln 
1               5                   10                  15      


Leu Pro Pro Leu Pro Gly Ala Arg Ala Gln Ser Ala Ala Gly Gly Cys 
            20                  25                  30          


Ser Phe Asp Glu His Tyr Ser Asn Cys Gly Tyr Ser Val Ala Leu Gly 
        35                  40                  45              


Thr Asn Gly Phe Thr Trp Glu Gln Ile Asn Thr Trp Glu Lys Pro Met 
    50                  55                  60                  


Leu Asp Gln Ala Val Pro Thr Gly Ser Phe Met Met Val Asn Ser Ser 
65                  70                  75                  80  


Gly Arg Ala Ser Gly Gln Lys Ala His Leu Leu Leu Pro Thr Leu Lys 
                85                  90                  95      


Glu Asn Asp Thr His Cys Ile Asp Phe His Tyr Tyr Phe Ser Ser Arg 
            100                 105                 110         


Asp Arg Ser Ser Pro Gly Ala Leu Asn Val Tyr Val Lys Val Asn Gly 
        115                 120                 125             


Gly Pro Gln Gly Asn Pro Val Trp Asn Val Ser Gly Val Val Thr Glu 
    130                 135                 140                 


Gly Trp Val Lys Ala Glu Leu Ala Ile Ser Thr Phe Trp Pro His Phe 
145                 150                 155                 160 


Tyr Gln Val Ile Phe Glu Ser Val Ser Leu Lys Gly His Pro Gly Tyr 
                165                 170                 175     


Ile Ala Val Asp Glu Val Arg Val Leu Ala His Pro Cys Arg Lys Ala 
            180                 185                 190         


Pro His Phe Leu Arg Leu Gln Asn Val Glu Val Asn Val Gly Gln Asn 
        195                 200                 205             


Ala Thr Phe Gln Cys Ile Ala Gly Gly Lys Trp Ser Gln His Asp Lys 
    210                 215                 220                 


Leu Trp Leu Gln Gln Trp Asn Gly Arg Asp Thr Ala Leu Met Val Thr 
225                 230                 235                 240 


Arg Val Val Asn His Arg Arg Phe Ser Ala Thr Val Ser Val Ala Asp 
                245                 250                 255     


Thr Ala Gln Arg Ser Val Ser Lys Tyr Arg Cys Val Ile Arg Ser Asp 
            260                 265                 270         


Gly Gly Ser Gly Val Ser Asn Tyr Ala Glu Leu Ile Val Lys Glu Pro 
        275                 280                 285             


Pro Thr Pro Ile Ala Pro Pro Glu Leu Leu Ala Val Gly Ala Thr Tyr 
    290                 295                 300                 


Leu Trp Ile Lys Pro Asn Ala Asn Ser Ile Ile Gly Asp Gly Pro Ile 
305                 310                 315                 320 


Ile Leu Lys Glu Val Glu Tyr Arg Thr Thr Thr Gly Thr Trp Ala Glu 
                325                 330                 335     


Thr His Ile Val Asp Ser Pro Asn Tyr Lys Leu Trp His Leu Asp Pro 
            340                 345                 350         


Asp Val Glu Tyr Glu Ile Arg Val Leu Leu Thr Arg Pro Gly Glu Gly 
        355                 360                 365             


Gly Thr Gly Pro Pro Gly Pro Pro Leu Thr Thr Arg Thr Lys Cys Ala 
    370                 375                 380                 


Asp Pro Val His Gly Pro Gln Asn Val Glu Ile Val Asp Ile Arg Ala 
385                 390                 395                 400 


Arg Gln Leu Thr Leu Gln Trp Glu Pro Phe Gly Tyr Ala Val Thr Arg 
                405                 410                 415     


Cys His Ser Tyr Asn Leu Thr Val Gln Tyr Gln Tyr Val Phe Asn Gln 
            420                 425                 430         


Gln Gln Tyr Glu Ala Glu Glu Val Ile Gln Thr Ser Ser His Tyr Thr 
        435                 440                 445             


Leu Arg Gly Leu Arg Pro Phe Met Thr Ile Arg Leu Arg Leu Leu Leu 
    450                 455                 460                 


Ser Asn Pro Glu Gly Arg Met Glu Ser Glu Glu Leu Val Val Gln Thr 
465                 470                 475                 480 


Glu Glu Asp Val Pro Gly Ala Val Pro Leu Glu Ser Ile Gln Gly Gly 
                485                 490                 495     


Pro Phe Glu Glu Lys Ile Tyr Ile Gln Trp Lys Pro Pro Asn Glu Thr 
            500                 505                 510         


Asn Gly Val Ile Thr Leu Tyr Glu Ile Asn Tyr Lys Ala Val Gly Ser 
        515                 520                 525             


Leu Asp Pro Ser Ala Asp Leu Ser Ser Gln Arg Gly Lys Val Phe Lys 
    530                 535                 540                 


Leu Arg Asn Glu Thr His His Leu Phe Val Gly Leu Tyr Pro Gly Thr 
545                 550                 555                 560 


Thr Tyr Ser Phe Thr Ile Lys Ala Ser Thr Ala Lys Gly Phe Gly Pro 
                565                 570                 575     


Pro Val Thr Thr Arg Ile Ala Thr Lys Ile Ser Ala Pro Ser Met Pro 
            580                 585                 590         


Glu Tyr Asp Thr Asp Thr Pro Leu Asn Glu Thr Asp Thr Thr Ile Thr 
        595                 600                 605             


Val Met Leu Lys Pro Ala Gln Ser Arg Gly Ala Pro Val Ser Val Tyr 
    610                 615                 620                 


Gln Leu Val Val Lys Glu Glu Arg Leu Gln Lys Ser Arg Arg Ala Ala 
625                 630                 635                 640 


Asp Ile Ile Glu Cys Phe Ser Val Pro Val Ser Tyr Arg Asn Ala Ser 
                645                 650                 655     


Ser Leu Asp Ser Leu His Tyr Phe Ala Ala Glu Leu Lys Pro Ala Asn 
            660                 665                 670         


Leu Pro Val Thr Gln Pro Phe Thr Val Gly Asp Asn Lys Thr Tyr Asn 
        675                 680                 685             


Gly Tyr Trp Asn Pro Pro Leu Ser Pro Leu Lys Ser Tyr Ser Ile Tyr 
    690                 695                 700                 


Phe Gln Ala Leu Ser Lys Ala Asn Gly Glu Thr Lys Ile Asn Cys Val 
705                 710                 715                 720 


Arg Leu Ala Thr Lys Gly Ala Ser Thr Gln Asn Ser Asn Thr Val Glu 
                725                 730                 735     


Pro Glu Lys Gln Val Asp Asn Thr Val Lys Met Ala Gly Val Ile Ala 
            740                 745                 750         


Gly Leu Leu Met Phe Ile Ile Ile Leu Leu Gly Val Met Leu Thr Ile 
        755                 760                 765             


Lys Arg Arg Arg Asn Ala Tyr Ser Tyr Ser Tyr Tyr Leu Lys Leu Ala 
    770                 775                 780                 


Lys Lys Gln Lys Glu Thr Gln Ser Gly Ala Gln Arg Glu Met Gly Pro 
785                 790                 795                 800 


Val Ala Ser Ala Asp Lys Pro Thr Thr Lys Leu Ser Ala Ser Arg Asn 
                805                 810                 815     


Asp Glu Gly Phe Ser Ser Ser Ser Gln Asp Val Asn Gly Phe Thr Asp 
            820                 825                 830         


Gly Ser Arg Gly Glu Leu Ser Gln Pro Thr Leu Thr Ile Gln Thr His 
        835                 840                 845             


Pro Tyr Arg Thr Cys Asp Pro Val Glu Met Ser Tyr Pro Arg Asp Gln 
    850                 855                 860                 


Phe Gln Pro Ala Ile Arg Val Ala Asp Leu Leu Gln His Ile Thr Gln 
865                 870                 875                 880 


Met Lys Arg Gly Gln Gly Tyr Gly Phe Lys Glu Glu Tyr Glu Ala Leu 
                885                 890                 895     


Pro Glu Gly Gln Thr Ala Ser Trp Asp Thr Ala Lys Glu Asp Glu Asn 
            900                 905                 910         


Arg Asn Lys Asn Arg Tyr Gly Asn Ile Ile Ser Tyr Asp His Ser Arg 
        915                 920                 925             


Val Arg Leu Leu Val Leu Asp Gly Asp Pro His Ser Asp Tyr Ile Asn 
    930                 935                 940                 


Ala Asn Tyr Ile Asp Gly Tyr His Arg Pro Arg His Tyr Ile Ala Thr 
945                 950                 955                 960 


Gln Gly Pro Met Gln Glu Thr Val Lys Asp Phe Trp Arg Met Ile Trp 
                965                 970                 975     


Gln Glu Asn Ser Ala Ser Ile Val Met Val Thr Asn Leu Val Glu Val 
            980                 985                 990         


Gly Arg Val Lys Cys Val Arg Tyr  Trp Pro Asp Asp Thr  Glu Val Tyr 
        995                 1000                 1005             


Gly Asp  Ile Lys Val Thr Leu  Ile Glu Thr Glu Pro  Leu Ala Glu 
    1010                 1015                 1020             


Tyr Val  Ile Arg Thr Phe Thr  Val Gln Lys Lys Gly  Tyr His Glu 
    1025                 1030                 1035             


Ile Arg  Glu Leu Arg Leu Phe  His Phe Thr Ser Trp  Pro Asp His 
    1040                 1045                 1050             


Gly Val  Pro Cys Tyr Ala Thr  Gly Leu Leu Gly Phe  Val Arg Gln 
    1055                 1060                 1065             


Val Lys  Phe Leu Asn Pro Pro  Glu Ala Gly Pro Ile  Val Val His 
    1070                 1075                 1080             


Cys Ser  Ala Gly Ala Gly Arg  Thr Gly Cys Phe Ile  Ala Ile Asp 
    1085                 1090                 1095             


Thr Met  Leu Asp Met Ala Glu  Asn Glu Gly Val Val  Asp Ile Phe 
    1100                 1105                 1110             


Asn Cys  Val Arg Glu Leu Arg  Ala Gln Arg Val Asn  Leu Val Gln 
    1115                 1120                 1125             


Thr Glu  Glu Gln Tyr Val Phe  Val His Asp Ala Ile  Leu Glu Ala 
    1130                 1135                 1140             


Cys Leu  Cys Gly Asn Thr Ala  Ile Pro Val Cys Glu  Phe Arg Ser 
    1145                 1150                 1155             


Leu Tyr  Tyr Asn Ile Ser Arg  Leu Asp Pro Gln Thr  Asn Ser Ser 
    1160                 1165                 1170             


Gln Ile  Lys Asp Glu Phe Gln  Thr Leu Asn Ile Val  Thr Pro Arg 
    1175                 1180                 1185             


Val Arg  Pro Glu Asp Cys Ser  Ile Gly Leu Leu Pro  Arg Asn His 
    1190                 1195                 1200             


Asp Lys  Asn Arg Ser Met Asp  Val Leu Pro Leu Asp  Arg Cys Leu 
    1205                 1210                 1215             


Pro Phe  Leu Ile Ser Val Asp  Gly Glu Ser Ser Asn  Tyr Ile Asn 
    1220                 1225                 1230             


Ala Ala  Leu Met Asp Ser His  Lys Gln Pro Ala Ala  Phe Val Val 
    1235                 1240                 1245             


Thr Gln  His Pro Leu Pro Asn  Thr Val Ala Asp Phe  Trp Arg Leu 
    1250                 1255                 1260             


Val Phe  Asp Tyr Asn Cys Ser  Ser Val Val Met Leu  Asn Glu Met 
    1265                 1270                 1275             


Asp Thr  Ala Gln Phe Cys Met  Gln Tyr Trp Pro Glu  Lys Thr Ser 
    1280                 1285                 1290             


Gly Cys  Tyr Gly Pro Ile Gln  Val Glu Phe Val Ser  Ala Asp Ile 
    1295                 1300                 1305             


Asp Glu  Asp Ile Ile His Arg  Ile Phe Arg Ile Cys  Asn Met Ala 
    1310                 1315                 1320             


Arg Pro  Gln Asp Gly Tyr Arg  Ile Val Gln His Leu  Gln Tyr Ile 
    1325                 1330                 1335             


Gly Trp  Pro Ala Tyr Arg Asp  Thr Pro Pro Ser Lys  Arg Ser Leu 
    1340                 1345                 1350             


Leu Lys  Val Val Arg Arg Leu  Glu Lys Trp Gln Glu  Gln Tyr Asp 
    1355                 1360                 1365             


Gly Arg  Glu Gly Arg Thr Val  Val His Cys Leu Asn  Gly Gly Gly 
    1370                 1375                 1380             


Arg Ser  Gly Thr Phe Cys Ala  Ile Cys Ser Val Cys  Glu Met Ile 
    1385                 1390                 1395             


Gln Gln  Gln Asn Ile Ile Asp  Val Phe His Ile Val  Lys Thr Leu 
    1400                 1405                 1410             


Arg Asn  Asn Lys Ser Asn Met  Val Glu Thr Leu Glu  Gln Tyr Lys 
    1415                 1420                 1425             


Phe Val  Tyr Glu Val Ala Leu  Glu Tyr Leu Ser Ser  Phe 
    1430                 1435                 1440     

<210>  3545
<211>  11977
<212>  DNA
<213>  Homo sapiens

<400>  3545
cctcccgcct cagttcgcgc cgcgcctcgg cttggaacgc aggagcgccg gctccgggag     60

cccgagcgga gccagccgcg cgcacagcca gcggccgcgc cggcgatgcg gggccacccc    120

gcgcccgccc cagtcccggc cccggccccc gcgggaaggg gctgagctgc ccgccgccgc    180

ccggatggcg agcctcgccg cgctcgccct cagcctgctc ctgaggctgc agctgccgcc    240

actgcccggc gcccgggctc agagcgccgc aggtggctgt tcctttgatg agcactacag    300

caactgtggt tatagtgtgg ctctagggac caatgggttc acctgggagc agattaacac    360

atgggagaaa ccaatgctgg accaggcagt gcccacagga tctttcatga tggtgaacag    420

ctctgggaga gcctctggcc agaaggccca ccttctcctg ccaaccctga aggagaatga    480

cacccactgc atcgacttcc attactactt ctccagccgt gacaggtcca gcccaggggc    540

cttgaacgtc tacgtgaagg tgaatggtgg cccccaaggg aaccctgtgt ggaatgtgtc    600

cggggtcgtc actgagggct gggtgaaggc agagctcgcc atcagcactt tctggccaca    660

tttctatcag gtgatatttg aatccgtctc attgaagggt catcctggct acatcgccgt    720

ggacgaggtc cgggtccttg ctcatccatg cagaaaagca cctcattttc tgcgactcca    780

aaacgtggag gtgaatgtgg ggcagaatgc cacatttcag tgcattgctg gtgggaagtg    840

gtctcagcat gacaagcttt ggctccagca atggaatggc agggacacgg ccctgatggt    900

cacccgtgtg gtcaaccaca ggcgcttctc agccacagtc agtgtggcag acactgccca    960

gcggagcgtc agcaagtacc gctgtgtgat ccgctctgat ggtgggtctg gtgtgtccaa   1020

ctacgcggag ctgatcgtga aagagcctcc cacgcccatt gctcccccag agctgctggc   1080

tgtgggggcc acatacctgt ggatcaagcc aaatgccaac tccatcatcg gggatggccc   1140

catcatcctg aaggaagtgg aatatcgcac caccacaggc acgtgggcag agacccacat   1200

agtcgactct cccaactata agctgtggca tctggacccc gatgttgagt atgagatccg   1260

agtgctcctc acacgaccag gtgagggggg tacgggaccg ccagggcctc ccctcaccac   1320

caggaccaag tgtgcagatc cggtacatgg cccacagaac gtggaaatcg tagacatcag   1380

agcccggcag ctgaccctgc agtgggagcc cttcggctac gcggtgaccc gctgccatag   1440

ctacaacctc accgtgcagt accagtatgt gttcaaccag cagcagtacg aggccgagga   1500

ggtcatccag acctcctccc actacaccct gcgaggcctg cgccccttca tgaccatccg   1560

gctgcgactc ttgctgtcta accccgaggg ccgaatggag agcgaggagc tggtggtgca   1620

gactgaggaa gacgttccag gagctgttcc tctagaatcc atccaagggg ggccctttga   1680

ggagaagatc tacatccagt ggaaacctcc caatgagacc aatggggtca tcacgctcta   1740

cgagatcaac tacaaggctg tcggctcgct ggacccaagt gctgacctct cgagccagag   1800

ggggaaagtg ttcaagctcc ggaatgaaac ccaccacctc tttgtgggtc tgtacccagg   1860

gaccacctat tccttcacca tcaaggccag cacagcaaag ggctttgggc cccctgtcac   1920

cactcggatt gccaccaaaa tttcagctcc atccatgcct gagtacgaca cagacacccc   1980

attgaatgag acagacacga ccatcacagt gatgctgaaa cccgctcagt cccggggagc   2040

tcctgtcagt gtttatcagc tggttgtcaa ggaggagcga cttcagaagt cacggagggc   2100

agctgacatt attgagtgct tttcggtgcc cgtgagctat cggaatgcct ccagcctcga   2160

ttctctacac tactttgctg ctgagttgaa gcctgccaac ctgcctgtca cccagccatt   2220

tacagtgggt gacaataaga catacaatgg ctactggaac cctcctctct ctcccctgaa   2280

aagctacagc atctacttcc aggcactcag caaagccaat ggagagacca aaatcaactg   2340

tgttcgtctg gctacaaaag caccaatggg cagcgcccag gtgaccccgg ggactccact   2400

ctgcctcctc accacaggtg cctccaccca gaattctaac actgtggagc cagagaagca   2460

ggtggacaac accgtgaaga tggctggcgt gatcgctggc ctcctcatgt tcatcatcat   2520

tctcctgggc gtgatgctca ccatcaaaag gagaagaaat gcttattcct actcctatta   2580

cttgaagctg gccaagaagc agaaggagac ccagagtgga gcccagaggg agatggggcc   2640

tgtggcctct gccgacaaac ccaccaccaa gctcagcgcc agccgcaatg atgaaggctt   2700

ctcttctagt tctcaggacg tcaacggatt cacagatggc agccgcgggg agctttccca   2760

gcccaccctc acgatccaga ctcatcccta ccgcacctgt gaccctgtgg agatgagcta   2820

cccccgggac cagttccaac ccgccatccg ggtggctgac ttgctgcagc acatcacgca   2880

gatgaagaga ggccagggct acgggttcaa ggaggaatac gaggccttac cagaggggca   2940

gacagcttcg tgggacacag ccaaggagga tgaaaaccgc aataagaatc gatatgggaa   3000

catcatatcc tacgaccatt cccgggtgag gctgctggtg ctggatggag acccgcactc   3060

tgactacatc aatgccaact acattgacgg ataccatcga cctcggcact acattgcgac   3120

tcaaggtccg atgcaggaga ctgtaaagga cttttggaga atgatctggc aggagaactc   3180

cgccagcatc gtcatggtca caaacctggt ggaagtgggc agggtgaaat gtgtgcgata   3240

ctggccagat gacacggagg tctacggaga cattaaagtc accctgattg aaacagagcc   3300

cctggcagaa tacgtcatac gcaccttcac agtccagaag aaaggctacc atgagatccg   3360

ggagctccgc ctcttccact tcaccagctg gcctgaccac ggcgttccct gctatgccac   3420

tggccttctg ggcttcgtcc gccaggtcaa gttcctcaac cccccggaag ctgggcccat   3480

agtggtccac tgcagtgctg gggctgggcg gactggctgc ttcattgcca ttgacaccat   3540

gcttgacatg gccgagaatg aaggggtggt ggacatcttc aactgcgtgc gtgagctccg   3600

ggcccaaagg gtcaacctgg tacagacaga ggagcaatat gtgtttgtgc acgatgccat   3660

cctggaagcg tgcctctgtg gcaacactgc catccctgtg tgtgagttcc gttctctcta   3720

ctacaatatc agcaggctgg acccccagac aaactccagc caaatcaaag atgaatttca   3780

gaccctcaac attgtgacac cccgtgtgcg gcccgaggac tgcagcattg ggctcctgcc   3840

ccggaaccat gataagaatc gaagtatgga cgtgctgcct ctggaccgct gcctgccctt   3900

ccttatctca gtggacggag aatccagcaa ttacatcaac gcagcactga tggatagcca   3960

caagcagcct gccgccttcg tggtcaccca gcaccctcta cccaacaccg tggcagactt   4020

ctggaggctg gtgttcgatt acaactgctc ctctgtggtg atgctgaatg agatggacac   4080

tgcccagttc tgtatgcagt actggcctga gaagacctcc gggtgctatg ggcccatcca   4140

ggtggagttc gtctccgcag acatcgacga ggacatcatc cacagaatat tccgcatctg   4200

taacatggcc cggccacagg atggttatcg tatagtccag cacctccagt acattggctg   4260

gcctgcctac cgggacacgc ccccctccaa gcgctctctg ctcaaagtgg tccgacgact   4320

ggagaagtgg caggagcagt atgacgggag ggagggacgt actgtggtcc actgcctaaa   4380

tgggggaggc cgtagtggaa ccttctgtgc catctgcagt gtgtgtgaga tgatccagca   4440

gcaaaacatc attgacgtgt tccacatcgt gaaaacactg cgtaacaaca aatccaacat   4500

ggtggagacc ctggaacagt ataaatttgt atacgaggtg gcactggaat atttaagctc   4560

cttttagctc aatgggatgg ggaacctgcc ggagtccaga ggctgctgtg accaagcccc   4620

cttttgtgtg aatggcagta actgggctca ggagctctga ggtggcaccc tgcctgactc   4680

caaggagaag actggtggcc ctgtgttcca cggggggctc tgcaccttct gaggggtctc   4740

ctgttgccgt gggagatgct gctccaaaag gcccaggctt ccttttcaac ctaaccagcc   4800

acagccaagg gcccaagcag aagtacaccc acaagcaagg ccttggattt ctggctccca   4860

gaccacctgc ttttgttctg agtttgtgga tctcttggca agccaactgt gcaggtgctg   4920

gggagtggga ggctcccctg ccctccttct ccttaggagt ggaggagatg tgtgttctgc   4980

tcctctacgt catggaaaag attgaggctc ttgggggtca ctgctctgct gccccctgca   5040

acctccttca ggggcctctg gcaccagaca tttgcagtct ggaccagtgt gaccttacga   5100

tgttccctag gccacaagag aggcccccca tcctcacacc taacctgcat ggggcttcgc   5160

ccacaaccat tctgtacccc ttccccagcc tgggccttga ccgtccagca ttcactggcc   5220

ggccagctgt gtccacagca gtttttgata aaggtgttct ttgctttttt gtgtggtcag   5280

tgggaggggg tggaactgca gggaacttct ctgctcctcc ttgtctttgt aaaaagggac   5340

cacctccctg gggcagggct tgggctgacc tgtaggatgt aacccctgtg tttctttggt   5400

ggtagctttc tttggaagag acaaacaaga taagatttga ttattttcca aagtgtatgt   5460

gaaaagaaac tttcttttgg agggtgtaaa atcttagtct cttatgtcaa aaagaagggg   5520

gcgggggagt ttgagtatgt acctctaaga caaatctctc gggcctttta ttttttcctg   5580

gcaatgtcct taaaagctcc caccctggga cagcatgcca ctgagcaagg agagatgggt   5640

gagcctgaag atggtccctt tggtttctgg ggcaaataga gcaccagctt tgtgcataat   5700

ttggatgtcc aaatttgaac tccttcctaa agaaacccag cagccacctt gaaaaaggcc   5760

attgtggagc ccattatact ttgatttaaa ataggccaag agaatcaggc ctggagatct   5820

agggtcttgt ccaaagtgtg agtgagtcaa tgagagggct tccttagtaa tgaaatcctg   5880

ggttccaaag gggcaggtaa tggcaatgag acttctccgt gctgttttct tcatcttctc   5940

taagccaagc aattatttta tggagggaaa ataaggccag aaacttctga gcagataact   6000

ccacaaatgg aaatttagta ctttcttcct gatgccagtt cttctgggaa gcgcagaatt   6060

tcagatatat tttagtaaca cattcccagc tccccaggaa agccagtctc atctaatttc   6120

ttagtcagta aaaacaattc cctgttcctt caggctatga atggaccagc cagggaaact   6180

ctcgaccttg atctctagcc agtgcttagg cccaatatct gacagcctca ggtgggctgg   6240

gacctaggaa gctccatctt gaaggctggt ctagccccag acagggcatg aggggcagag   6300

aattcaagaa ggtacagctt tggccctcaa gagcccactg tatgctgggg aaatggaacc   6360

atggtgcagt agtgtggagt ggatgagtgt tccatgagcc taggagcaag aaagtctctt   6420

cggcctcggc ccatcgcgag tacagacttt gtcctattgg caacaaggag tccatggagc   6480

tttagagaga tgcactcagc ttcgtgttgg ccaagactcc ttctgggcca atggggctgc   6540

ctcttttcct ttcatcagac actgtgaaaa cattccctta agcgtgcact ttttaatatc   6600

acatctattt gtctgtctgc tcattgtttt gttgctggaa ctaaatatgc aatggatcat   6660

gagactcaga ttctatgaga aacccagggt ctctgcttta ccacggagca gggtcaccaa   6720

cccagatctc caggcccatg aggatggaac atgaaaggag ccgacaaaag ttgcttccat   6780

tggcatgggc tctggagctg tccagaagtc cagggacacc agacttgatc aaggaagggc   6840

tgtcacttta gaggttcaaa aggaagtgcc tcaaagcaaa ggcaagcaaa ggaaccccac   6900

gatgaacttg ctcttttcct ttgatgagcc tctccccagg tgtatttcag cagaccccgg   6960

ggacccaccc ccactgggcc tgctggcctc cctcggctcc agcccaatgc cccagctggc   7020

cttccccagc ctgcaaggag cctgtagcat ggcaaatctg cctgctgtat gctattttct   7080

tagatcttgg tacatccaga caggatgagg gtggagggag agctatttaa cacaaatcct   7140

aagatttttt tctgctcagg aaggggtgaa atagctggca gatacaaaag acagtggctt   7200

ttatcatttt aaatggtagg aatttaaggt gtgacttcag ggagaaacaa acttgcaaaa   7260

aaaaaaaatc tcaggccatg ttggggtaac ccagcaaggg ccagtgatga tttcccccag   7320

ctcatccctg gggcaccagt gcccaggaat ttgaacattt tcctttaccc aggaaatctc   7380

cggagccaac accaccaccc ccagggggtc tccccacccc accccattta cagggtgagc   7440

tcagcctgtc atgagcagag gaaaatatta ttaatgctct ctgagtcttt acaacaggag   7500

ctcttacctc atagatgtgg gctctgtttg gggaagatgc aaggaagtaa tgagaagccc   7560

aggaaatttc tccacctgtg tttatggcct aaatagcttc aggatgtatc ttagctgcac   7620

tccaacattg catcctttct ggggtgaaga atctgggcca accaggggtc cttgggcctc   7680

tagaaggcca cagtaggcct ctctttgtgg gaatggaagg ggacagtttg cttttagtgc   7740

tggccctctc tgtgggtgtg gcctgcaaag gaaccaacat tgtatctcac atttttccca   7800

ggaggttacc cataacagaa gagactagag tggaacagat acgtcagtgg ataaagctca   7860

aagcaaacaa cagtaagctt aaaattcctt catagtctca tgttttacgt tcacaattca   7920

tgcaaaattt gcattccact ttctgattta gccttgttgg ttttaatatg actctatgaa   7980

tatttcaaaa aaaaatgtgc tctgttcctc atgttgttct gttctgttca ccccgctatg   8040

acggacccta ggtcagctgg tcttcagctt gaccctagaa ttgactctag gagcagtgac   8100

cctgctgcct cccagagcca gttataggct caagatcaag accaactgac cttctcctag   8160

gcagctcctt tggtgtgtgg gtgctctgac ctcactgttc atgaggggac ctcaactaag   8220

gcatcttcca gttgggtgct ggaaggaacc cattaactca cactagaatg atgaggattt   8280

gctcatctgg cgtggagaag gatgagccca caaaacccta aagggaaaag agaagctgga   8340

cacagctgta ctcagcagat tcctgaatgc taggctggaa agtggtgcct gttgtccaag   8400

tggagtcaca tggttgctaa tgtgggcaag tctgaggaca cacttcatga gcagctgggg   8460

tctggaaggc tcctcacttt accctagcca cacataatta ctgggtgcct acagcaccta   8520

gcaccttgga gggggcacta ttaggaaatc gagattacta tggcacaatt aattcctggg   8580

taaggcatgg ggttgtggtg gacagagctc agtctttagt ttgaacgaaa acatacatac   8640

atgaaaaaca tacatgaaaa aaggaccctc atcaacatta gaaggggtag atttggagca   8700

ctttaggcag gaaaacagga acgcaaggcc aggaaactgg aacccagtga atactcagaa   8760

ccgaggatgc agatgactta tttagcaaaa tggtcacttc tgtgacatag ctggagaaag   8820

gatgggtaac agcttgccag agccacttgg aacaagggca aatctcagtg tctggggcaa   8880

aagatgatgc atttccctct gacccatcat gtttattcat cctccactcc ccattgccac   8940

actagctctt gctgtaagtc ctcaccagga tctacatttc ctcgtcgctg gtgggaaccc   9000

cttagagtac atagaggtat cagtccagta agactgctct acacaacaga agtgaggccc   9060

agggagtagc agccaggccc ttatcctgtt acctctgcag gagtgactgc ccaacccaga   9120

tccagagaca ttgaaggaaa tgataattcc ttggtacctc actgccttgg gacaaaatga   9180

agaaagccac ccttccttag gctgcagctt gccactcctg ggctgggtaa acaggtcatc   9240

agcaccaagc tcaaccagga gtaacactct ggaagacatg ggtgagccca agaggaagca   9300

tgaacaggac gctgttccta agtcatgtca acaggttgtg ctgggccagg atccccaggg   9360

aaaaaaatgg tcaacccaac tggagggtag gttagaagaa aaaaaacata aacgtggata   9420

gtcatgtcat ctcaaatccc tgacttggct tccccattac ttaacagtct gagctccttc   9480

ttagcctgtg accagcttca aatcacagcc aagtaaaaca aggaaatagg aaaagtaaat   9540

ccaactagaa gagacaagct gagattcaga tttgtttact cctcccatgc aaagtttccc   9600

tgttggaggt tttccatgta tacatgtcta gaagtgatag aatgcaaggc cttggctttg   9660

tcttgcaggg atctgccttt gaggtcatag actgaacagc agggagagag gttagtggtg   9720

gagtgtgggg ggagctgttc tagctccagt ttcttctgac acatttttca ggatcatgga   9780

tctgatcctc cgaagcacag cagagatatc taagccatat ttgtgcacat gagcagactc   9840

ttctagtttt ttagtaacca gggatgggct tttgcatggc actgactata gagatgtctt   9900

gtagagatca agccagtctt ttgcatccca cctgcccacc tccagaagag atgggaaaag   9960

gtcatcaaag ggcattcacc aactgaaatc cactcatgaa tgttaggtct ctaaaaggag  10020

gcatcaacac tcacaatggt agcctccaaa cctagcatcc cacctatcta agagctcagg  10080

ggtggtccac tggggcagat acaagggaag tgcaagggct caggatgaaa gaaaatctat  10140

tgggaagagt tttaggggct tgatcattat ggggcttcct tctatatctg agaactgctc  10200

tgggtggtga gatgtggact ctgatcctta attggaatgt tcggagaatg agtgtctggt  10260

ggccttgaag tgttggacag aaaagtatca gtataaaagc ctggagctca gggtaattaa  10320

tgtagttcat ggttccttag tgagcaggac tcttggatgt ggaggagaaa gggtcatagg  10380

aagtaaacca ccaaaattac aaaattgagt ctctgtacaa ttacttcagt gcctttgggc  10440

ttatgaatac aaatcagtgg gccttctcta tgatggtcca acaaactctc agtgtccacc  10500

ctgtccctgt atctcccatg gaagatgaat aatgtcaggt gttctttggg tcaaaggccc  10560

cagggcagtc tggaggctta gagggcagag tggtgtcatt ccatgtaaag ttaggcttct  10620

gaggggtcag gcagaatatg gtgtccatat cttccatagc tctgcagatt cttggatgaa  10680

gtcaagcaca gtttgctaga cccaggtcac tcctctgagt ataactagga cccatgagtg  10740

aaacttaata gctgtaagga agaacctgct gtctgccaga gaggataagc tgcccatctc  10800

agcagctgtc taaaagaagg caggtgtctc tttaaaggga agagaagcat tggtgaaatg  10860

gatttcaggt cacttccatt ccagatgggt gagatcttgt ggagctggga tcatgtttga  10920

actcattcat acctgtagag cacgaatcca agtagattgt gtttggtctg tacaggctga  10980

agccccctgc tctcccaccc aagtgccccc actgagcagg ccaacatgct gttgtggcca  11040

catatactgg gctgatccag gctggttatc accaaacagc aaaccatagg gaacagctgc  11100

tttgccatag acccaatacc catgtagatc tctcatgaga gcagccataa ctcagaccca  11160

ctgaccaaca gggccatgag tgacagccag aaccagtgaa ggtccaagta ggacacagag  11220

cagggctttt cttaccatac acattatctc cagaggttat ttctacccca ctccctattc  11280

aaggcctgtt ggagcacact gcaaaagcaa aagcacagta actcaattta cacatgatta  11340

taatcatttc cagtgcacac atttcatcac caggtggatc ctgagctagc ccatgtaaat  11400

ccgggttaac ccatattggt aatcatactc aaaagcactt ttcaccctac attctactag  11460

ccaatcaaag acaaagagtt gtggcctcta ccattgcctt ggcttctgga caccctcaca  11520

agctatccca aggttcccgc tcaactccag ggaggctgac atcttcacat ccactgggca  11580

tataatattg catgagacca aagtctccac actctttgca gcctcctcca tgaatcccaa  11640

tggcctgcac ttgtacagtt tgggtgtttg atagataaag cacgtatgag aagagaaaac  11700

aaaataaatc aactttttaa aaaagccagc actgtgctgt caatgttttt tttttctttt  11760

caattctagc tcagaaaagc agaaggtaaa taatgtcagg tcaatgaata tcagatatat  11820

tttttgactg tacattacag tgaagtgtaa tctttttaca cctgcaagtc catcttattt  11880

attcttgtaa atgttccctg acaatgtttg taacatggct gtgttaaaaa atctatacaa  11940

taaagctgtg accctgagat tcatgttttc ctaagat                           11977


<210>  3546
<211>  1460
<212>  PRT
<213>  Homo sapiens

<400>  3546


Met Ala Ser Leu Ala Ala Leu Ala Leu Ser Leu Leu Leu Arg Leu Gln 
1               5                   10                  15      


Leu Pro Pro Leu Pro Gly Ala Arg Ala Gln Ser Ala Ala Gly Gly Cys 
            20                  25                  30          


Ser Phe Asp Glu His Tyr Ser Asn Cys Gly Tyr Ser Val Ala Leu Gly 
        35                  40                  45              


Thr Asn Gly Phe Thr Trp Glu Gln Ile Asn Thr Trp Glu Lys Pro Met 
    50                  55                  60                  


Leu Asp Gln Ala Val Pro Thr Gly Ser Phe Met Met Val Asn Ser Ser 
65                  70                  75                  80  


Gly Arg Ala Ser Gly Gln Lys Ala His Leu Leu Leu Pro Thr Leu Lys 
                85                  90                  95      


Glu Asn Asp Thr His Cys Ile Asp Phe His Tyr Tyr Phe Ser Ser Arg 
            100                 105                 110         


Asp Arg Ser Ser Pro Gly Ala Leu Asn Val Tyr Val Lys Val Asn Gly 
        115                 120                 125             


Gly Pro Gln Gly Asn Pro Val Trp Asn Val Ser Gly Val Val Thr Glu 
    130                 135                 140                 


Gly Trp Val Lys Ala Glu Leu Ala Ile Ser Thr Phe Trp Pro His Phe 
145                 150                 155                 160 


Tyr Gln Val Ile Phe Glu Ser Val Ser Leu Lys Gly His Pro Gly Tyr 
                165                 170                 175     


Ile Ala Val Asp Glu Val Arg Val Leu Ala His Pro Cys Arg Lys Ala 
            180                 185                 190         


Pro His Phe Leu Arg Leu Gln Asn Val Glu Val Asn Val Gly Gln Asn 
        195                 200                 205             


Ala Thr Phe Gln Cys Ile Ala Gly Gly Lys Trp Ser Gln His Asp Lys 
    210                 215                 220                 


Leu Trp Leu Gln Gln Trp Asn Gly Arg Asp Thr Ala Leu Met Val Thr 
225                 230                 235                 240 


Arg Val Val Asn His Arg Arg Phe Ser Ala Thr Val Ser Val Ala Asp 
                245                 250                 255     


Thr Ala Gln Arg Ser Val Ser Lys Tyr Arg Cys Val Ile Arg Ser Asp 
            260                 265                 270         


Gly Gly Ser Gly Val Ser Asn Tyr Ala Glu Leu Ile Val Lys Glu Pro 
        275                 280                 285             


Pro Thr Pro Ile Ala Pro Pro Glu Leu Leu Ala Val Gly Ala Thr Tyr 
    290                 295                 300                 


Leu Trp Ile Lys Pro Asn Ala Asn Ser Ile Ile Gly Asp Gly Pro Ile 
305                 310                 315                 320 


Ile Leu Lys Glu Val Glu Tyr Arg Thr Thr Thr Gly Thr Trp Ala Glu 
                325                 330                 335     


Thr His Ile Val Asp Ser Pro Asn Tyr Lys Leu Trp His Leu Asp Pro 
            340                 345                 350         


Asp Val Glu Tyr Glu Ile Arg Val Leu Leu Thr Arg Pro Gly Glu Gly 
        355                 360                 365             


Gly Thr Gly Pro Pro Gly Pro Pro Leu Thr Thr Arg Thr Lys Cys Ala 
    370                 375                 380                 


Asp Pro Val His Gly Pro Gln Asn Val Glu Ile Val Asp Ile Arg Ala 
385                 390                 395                 400 


Arg Gln Leu Thr Leu Gln Trp Glu Pro Phe Gly Tyr Ala Val Thr Arg 
                405                 410                 415     


Cys His Ser Tyr Asn Leu Thr Val Gln Tyr Gln Tyr Val Phe Asn Gln 
            420                 425                 430         


Gln Gln Tyr Glu Ala Glu Glu Val Ile Gln Thr Ser Ser His Tyr Thr 
        435                 440                 445             


Leu Arg Gly Leu Arg Pro Phe Met Thr Ile Arg Leu Arg Leu Leu Leu 
    450                 455                 460                 


Ser Asn Pro Glu Gly Arg Met Glu Ser Glu Glu Leu Val Val Gln Thr 
465                 470                 475                 480 


Glu Glu Asp Val Pro Gly Ala Val Pro Leu Glu Ser Ile Gln Gly Gly 
                485                 490                 495     


Pro Phe Glu Glu Lys Ile Tyr Ile Gln Trp Lys Pro Pro Asn Glu Thr 
            500                 505                 510         


Asn Gly Val Ile Thr Leu Tyr Glu Ile Asn Tyr Lys Ala Val Gly Ser 
        515                 520                 525             


Leu Asp Pro Ser Ala Asp Leu Ser Ser Gln Arg Gly Lys Val Phe Lys 
    530                 535                 540                 


Leu Arg Asn Glu Thr His His Leu Phe Val Gly Leu Tyr Pro Gly Thr 
545                 550                 555                 560 


Thr Tyr Ser Phe Thr Ile Lys Ala Ser Thr Ala Lys Gly Phe Gly Pro 
                565                 570                 575     


Pro Val Thr Thr Arg Ile Ala Thr Lys Ile Ser Ala Pro Ser Met Pro 
            580                 585                 590         


Glu Tyr Asp Thr Asp Thr Pro Leu Asn Glu Thr Asp Thr Thr Ile Thr 
        595                 600                 605             


Val Met Leu Lys Pro Ala Gln Ser Arg Gly Ala Pro Val Ser Val Tyr 
    610                 615                 620                 


Gln Leu Val Val Lys Glu Glu Arg Leu Gln Lys Ser Arg Arg Ala Ala 
625                 630                 635                 640 


Asp Ile Ile Glu Cys Phe Ser Val Pro Val Ser Tyr Arg Asn Ala Ser 
                645                 650                 655     


Ser Leu Asp Ser Leu His Tyr Phe Ala Ala Glu Leu Lys Pro Ala Asn 
            660                 665                 670         


Leu Pro Val Thr Gln Pro Phe Thr Val Gly Asp Asn Lys Thr Tyr Asn 
        675                 680                 685             


Gly Tyr Trp Asn Pro Pro Leu Ser Pro Leu Lys Ser Tyr Ser Ile Tyr 
    690                 695                 700                 


Phe Gln Ala Leu Ser Lys Ala Asn Gly Glu Thr Lys Ile Asn Cys Val 
705                 710                 715                 720 


Arg Leu Ala Thr Lys Ala Pro Met Gly Ser Ala Gln Val Thr Pro Gly 
                725                 730                 735     


Thr Pro Leu Cys Leu Leu Thr Thr Gly Ala Ser Thr Gln Asn Ser Asn 
            740                 745                 750         


Thr Val Glu Pro Glu Lys Gln Val Asp Asn Thr Val Lys Met Ala Gly 
        755                 760                 765             


Val Ile Ala Gly Leu Leu Met Phe Ile Ile Ile Leu Leu Gly Val Met 
    770                 775                 780                 


Leu Thr Ile Lys Arg Arg Arg Asn Ala Tyr Ser Tyr Ser Tyr Tyr Leu 
785                 790                 795                 800 


Lys Leu Ala Lys Lys Gln Lys Glu Thr Gln Ser Gly Ala Gln Arg Glu 
                805                 810                 815     


Met Gly Pro Val Ala Ser Ala Asp Lys Pro Thr Thr Lys Leu Ser Ala 
            820                 825                 830         


Ser Arg Asn Asp Glu Gly Phe Ser Ser Ser Ser Gln Asp Val Asn Gly 
        835                 840                 845             


Phe Thr Asp Gly Ser Arg Gly Glu Leu Ser Gln Pro Thr Leu Thr Ile 
    850                 855                 860                 


Gln Thr His Pro Tyr Arg Thr Cys Asp Pro Val Glu Met Ser Tyr Pro 
865                 870                 875                 880 


Arg Asp Gln Phe Gln Pro Ala Ile Arg Val Ala Asp Leu Leu Gln His 
                885                 890                 895     


Ile Thr Gln Met Lys Arg Gly Gln Gly Tyr Gly Phe Lys Glu Glu Tyr 
            900                 905                 910         


Glu Ala Leu Pro Glu Gly Gln Thr Ala Ser Trp Asp Thr Ala Lys Glu 
        915                 920                 925             


Asp Glu Asn Arg Asn Lys Asn Arg Tyr Gly Asn Ile Ile Ser Tyr Asp 
    930                 935                 940                 


His Ser Arg Val Arg Leu Leu Val Leu Asp Gly Asp Pro His Ser Asp 
945                 950                 955                 960 


Tyr Ile Asn Ala Asn Tyr Ile Asp Gly Tyr His Arg Pro Arg His Tyr 
                965                 970                 975     


Ile Ala Thr Gln Gly Pro Met Gln Glu Thr Val Lys Asp Phe Trp Arg 
            980                 985                 990         


Met Ile Trp Gln Glu Asn Ser Ala  Ser Ile Val Met Val  Thr Asn Leu 
        995                 1000                 1005             


Val Glu  Val Gly Arg Val Lys  Cys Val Arg Tyr Trp  Pro Asp Asp 
    1010                 1015                 1020             


Thr Glu  Val Tyr Gly Asp Ile  Lys Val Thr Leu Ile  Glu Thr Glu 
    1025                 1030                 1035             


Pro Leu  Ala Glu Tyr Val Ile  Arg Thr Phe Thr Val  Gln Lys Lys 
    1040                 1045                 1050             


Gly Tyr  His Glu Ile Arg Glu  Leu Arg Leu Phe His  Phe Thr Ser 
    1055                 1060                 1065             


Trp Pro  Asp His Gly Val Pro  Cys Tyr Ala Thr Gly  Leu Leu Gly 
    1070                 1075                 1080             


Phe Val  Arg Gln Val Lys Phe  Leu Asn Pro Pro Glu  Ala Gly Pro 
    1085                 1090                 1095             


Ile Val  Val His Cys Ser Ala  Gly Ala Gly Arg Thr  Gly Cys Phe 
    1100                 1105                 1110             


Ile Ala  Ile Asp Thr Met Leu  Asp Met Ala Glu Asn  Glu Gly Val 
    1115                 1120                 1125             


Val Asp  Ile Phe Asn Cys Val  Arg Glu Leu Arg Ala  Gln Arg Val 
    1130                 1135                 1140             


Asn Leu  Val Gln Thr Glu Glu  Gln Tyr Val Phe Val  His Asp Ala 
    1145                 1150                 1155             


Ile Leu  Glu Ala Cys Leu Cys  Gly Asn Thr Ala Ile  Pro Val Cys 
    1160                 1165                 1170             


Glu Phe  Arg Ser Leu Tyr Tyr  Asn Ile Ser Arg Leu  Asp Pro Gln 
    1175                 1180                 1185             


Thr Asn  Ser Ser Gln Ile Lys  Asp Glu Phe Gln Thr  Leu Asn Ile 
    1190                 1195                 1200             


Val Thr  Pro Arg Val Arg Pro  Glu Asp Cys Ser Ile  Gly Leu Leu 
    1205                 1210                 1215             


Pro Arg  Asn His Asp Lys Asn  Arg Ser Met Asp Val  Leu Pro Leu 
    1220                 1225                 1230             


Asp Arg  Cys Leu Pro Phe Leu  Ile Ser Val Asp Gly  Glu Ser Ser 
    1235                 1240                 1245             


Asn Tyr  Ile Asn Ala Ala Leu  Met Asp Ser His Lys  Gln Pro Ala 
    1250                 1255                 1260             


Ala Phe  Val Val Thr Gln His  Pro Leu Pro Asn Thr  Val Ala Asp 
    1265                 1270                 1275             


Phe Trp  Arg Leu Val Phe Asp  Tyr Asn Cys Ser Ser  Val Val Met 
    1280                 1285                 1290             


Leu Asn  Glu Met Asp Thr Ala  Gln Phe Cys Met Gln  Tyr Trp Pro 
    1295                 1300                 1305             


Glu Lys  Thr Ser Gly Cys Tyr  Gly Pro Ile Gln Val  Glu Phe Val 
    1310                 1315                 1320             


Ser Ala  Asp Ile Asp Glu Asp  Ile Ile His Arg Ile  Phe Arg Ile 
    1325                 1330                 1335             


Cys Asn  Met Ala Arg Pro Gln  Asp Gly Tyr Arg Ile  Val Gln His 
    1340                 1345                 1350             


Leu Gln  Tyr Ile Gly Trp Pro  Ala Tyr Arg Asp Thr  Pro Pro Ser 
    1355                 1360                 1365             


Lys Arg  Ser Leu Leu Lys Val  Val Arg Arg Leu Glu  Lys Trp Gln 
    1370                 1375                 1380             


Glu Gln  Tyr Asp Gly Arg Glu  Gly Arg Thr Val Val  His Cys Leu 
    1385                 1390                 1395             


Asn Gly  Gly Gly Arg Ser Gly  Thr Phe Cys Ala Ile  Cys Ser Val 
    1400                 1405                 1410             


Cys Glu  Met Ile Gln Gln Gln  Asn Ile Ile Asp Val  Phe His Ile 
    1415                 1420                 1425             


Val Lys  Thr Leu Arg Asn Asn  Lys Ser Asn Met Val  Glu Thr Leu 
    1430                 1435                 1440             


Glu Gln  Tyr Lys Phe Val Tyr  Glu Val Ala Leu Glu  Tyr Leu Ser 
    1445                 1450                 1455             


Ser Phe  
    1460 

<210>  3547
<211>  2420
<212>  DNA
<213>  Homo sapiens

<400>  3547
gttcttgaca ttaatgaagt tgcctcctga atttcactgt taaggatgac tttggcattt     60

ggtttgaaat gttaattttt atttatcatc ttgaggagaa ggcaatatga agatagagac    120

aatggagatt ttaaaacgtt gattggtgga gactggaaag ttgtggtcag aagccaagga    180

atgctgacag ccaccataaa ctggaagagg gtcttgctct attgcacagg agtgcagtgg    240

tacaatcatg gctgtctgcg gcctcaatct ccctggctta agcaatcctc ctgcctcagc    300

ctcccaaagt agctgggact acaggaaaag tgtcaggccc attgaagtta ccacgtgcca    360

tggctgtgag tgccttcact acttggagta ggctcatcag tagacaaccc tcccagagct    420

ctacgtgcag ccggcatctg cgcggtctgt taggccttgc tctgttgccc aagctggagt    480

gggcaacaac ccatccacct tggcctccca aagtgctggg attacagcca cctattctag    540

aggagcagta ttgaagggct tggggaaacc gagtgctctc taagtgtggc cctcaccatc    600

cttcctggtg cgctatctcc agccgtgcat ccgaaaacat cccagtctgc ccctggcctc    660

tgcatggagc ctgaccccca acacagacct ctcaagaggt tctggattca ctggtgctgc    720

tacagccctg agcaaaaaca cagctgtttc gtttaccacc ccaccccaac ataagctgtc    780

ctcagacttt acaaagactt agggattgca cagtccacaa gactttcaat gcctttgccc    840

tgtatctcaa ctaactttca aatagaggga ccttcttata ggaagaagaa ggaaaaatca    900

agtggaaaaa caccttgatc aggtaattga aggagaactg gggctcaggc tgccacttgg    960

tttggaaagg gtgtggaggt ggctaatctg gccctggcct aagagcaatt ccaggctggc   1020

gggctggacc gcctgtctcc atagcaactg ttgttattgg taactgaata accatttcct   1080

agaacagcgg ctggagctgc tgatggtttt cccttctact tggaagcgag aggagccagg   1140

ctctttgctg attgatccta agtgctgagc tctttgctga ttgggatctt cacttgatat   1200

tgggcaagct gaagccaccc ttctgtttta tctctgacct ctgccagcag agagggtggg   1260

acaaactgac ttaatgtcta ttttccggct tcctctgaga ggttgagaaa ggtgctcaag   1320

ggcatttagc tagcaagatc tagaacttga actttgccct gtctgattct gaaacccatg   1380

ctcgtgacca catggctgtt ctgactctgt cccattcctc tgagatctca tgaaaacctg   1440

attagccctt tctcatgaca ccatgagctg tctaattatt tgtgaggaca ggtagcatct   1500

tacagtgatc catggtctgc acaaaggctg ttctagaagc tgtcttactt gattatcctg   1560

cagtggtgtc agtgggacct taaaatgctg tagccctaga gttattaggg ctattgtgtt   1620

tgttaccaag ccaaaggagc ttgctgccca atgcactaga agccaatact atgacactgg   1680

gtttttgaga aacaaaaagc tttttaagtc gactaacaag gagacaggag tccggctcaa   1740

atctgtctcc ctgtgctggc tttcagtcat ttcattaaaa aaggttgagg gggtagattc   1800

tgggattagc ggatgattgg tggaaggaaa ggggaggtct ggaaagtcct cgggcacgcg   1860

cagttctctc tctatgctac cacatgtgca aatttgcggg gagtgttcat gtggaacagg   1920

cagtgtttcc tgtttccaga ccaggcaagg tggctcacaa atggctctac gatccagaga   1980

aagtcagcag ggagggttgt gatttgttat tatgaaaaat taacaaatta catccaaaat   2040

gtgtttaact cctattccct ttgaaaagga tctttgggta cctaattgac atattttaag   2100

agacatattg gctagttaga catcaattga catcctcatt aaatatcaat taacacatat   2160

cctaacgtaa tatttaatta gcttgctgta gctattcttt taaaagtcaa ttaaatgctt   2220

ggcatattct tacaagccga ctccattgat agcaattatg gatgaattcc tgtcataagt   2280

catttttagt ggatagcagg gcaaactgat tctgaatata cacatcaggt ctttcaagaa   2340

gaatttaaaa atcaatcatt agatatctaa tgaaccctct tctctgctga ttgtgaataa   2400

aaggcatgtt cggctcttgg                                               2420


<210>  3548
<211>  64
<212>  PRT
<213>  Homo sapiens

<400>  3548


Met Ala Val Ser Ala Phe Thr Thr Trp Ser Arg Leu Ile Ser Arg Gln 
1               5                   10                  15      


Pro Ser Gln Ser Ser Thr Cys Ser Arg His Leu Arg Gly Leu Leu Gly 
            20                  25                  30          


Leu Ala Leu Leu Pro Lys Leu Glu Trp Ala Thr Thr His Pro Pro Trp 
        35                  40                  45              


Pro Pro Lys Val Leu Gly Leu Gln Pro Pro Ile Leu Glu Glu Gln Tyr 
    50                  55                  60                  

<210>  3549
<211>  2024
<212>  DNA
<213>  Homo sapiens

<400>  3549
aagtttgaag gattcagagc agagaattgc accctggcat gatgcctatg ccagctggac     60

tgtgtgattt ttgttcttta gtagaaggat aacatgacat agcaggaata atactgcctt    120

ttctttctgg catggatcaa gagaaaagaa aatacaagaa aacagacaga agcaaggcaa    180

ggtacttcta tggaagggtg agccctcaca gatggagcaa tggggcgcgc acacctgaac    240

aagggagggg aaggagttct tatccctgat gcatgtgacc cctgctgctg tgtccttccc    300

ctattggcta aggcttctga cagctttgga gattgtgaca ttggaataaa ggaaaaacgt    360

acaggactca tgaagcgctg aaatgttcac aaatatcaag caaaagtcaa tgaaatttat    420

tttgagctat ttacatcatt taataattga gcaaggtata ctcctatgaa caaaatttgg    480

agcatgtttg tctctctctg cctggcgtct tcagaatttg gaaactagtt atggtttata    540

atcagctata gaattttaac acgtgctctc aaatgcaagt ttctgataac tttggagatt    600

gtgacattgg aataaaggaa gagctggaat gttcatgaat atcaagcaaa agtcatggaa    660

atttattttg agctatttac agcatttaat aattgagcaa ggtatactcc tatgaacaaa    720

atttggagca tgtttgtctc tctctgtctg cctggcatct acagaatttg gaaactagtt    780

tcgttcccag atttcctaaa ctttccagag aaaatggtct tctccctggc tcagcaagaa    840

gatgaacttt aaacactgag aaactggtca tctccctggc tcaaccagaa gatgaacttt    900

aaacactact ctcaatgact tgatgttccc atcactactc ctgtcataaa gggaggggac    960

tcagatattg agaattttat gatagtgtga actgtctggt atgtcattta agtaagcccg   1020

ttgctgaaat attttccatg ttattagaaa gagctgaaga gagggattga gatggcttct   1080

ttattttttg tcttttggga attaaaggaa cctggttcaa caagggccta cacctaagtc   1140

tcttgttgta ccagagtaca atttaggact gctcctgagg aaggaattag ctagaaatct   1200

agagagtaag ggtaacagat ttacatagaa taacagcctc agtatttttg gttcctctcc   1260

agtaaagatc acaaagaata ttgctaaatc gctaaaacac ctttgcaata acgtaagggc   1320

ttacaactat ataccaatgt agctcagtta ctaaactgga gtaaactaat ttctcttgtg   1380

tagaaaaatt ggttggctgt ggttttatag cagatctgca attattaata gttatgccaa   1440

taatcgttta acagtgcata tgttaatata tatggaaaga caatgtgtat agacagatgt   1500

gtaaaattga aaaataaaca tataacaaga gagaaacatc tatcgaacag acaatataca   1560

tacacatcaa acacaacagc agttttagtg accataatat ttatttctca tttttacatt   1620

gcttacttta gtgacaactg aaaatgacag ttggcaatgc agctaacagt ttcaataaaa   1680

gtataaaaca aaagactgtg tacaaagcac ctgtctttcc gcttttgtaa tcttccgttg   1740

gaaaaaattt acacacctaa gtaaccatct gttttcttca agaaaaaatc attcttattt   1800

ctctctctca tcttgaaaac agctgtcagc caggagggca gagctgaaat ttattgccac   1860

atcacatgaa gcatagaaca gactccacta ctccttgaga ttcaaaactt tgcctctcac   1920

aaagttacct tttattttcc tcttgtttgt cactcatctc ccctagtgtg ctctttttat   1980

ttcttttact attaataata aaatctgtgg atgactgtat tatt                    2024


<210>  3550
<211>  53
<212>  PRT
<213>  Homo sapiens

<400>  3550


Met Gly Arg Ala His Leu Asn Lys Gly Gly Glu Gly Val Leu Ile Pro 
1               5                   10                  15      


Asp Ala Cys Asp Pro Cys Cys Cys Val Leu Pro Leu Leu Ala Lys Ala 
            20                  25                  30          


Ser Asp Ser Phe Gly Asp Cys Asp Ile Gly Ile Lys Glu Lys Arg Thr 
        35                  40                  45              


Gly Leu Met Lys Arg 
    50              

<210>  3551
<211>  2077
<212>  DNA
<213>  Homo sapiens

<400>  3551
aagtttgaag gattcagagc agagaattgc accctggcat gatgcctatg ccagctggac     60

tgtgtgattt ttgttcttta gtagaaggat aacatgacat agcaggaata atactgcctt    120

ttctttctgg catggatcaa gagaaaagaa aatacaagaa aacagacaga agatcctatc    180

tgcgacaatt aagagcactc taagaggaaa acacatccca ccacacaagg caaggtactt    240

ctatggaagg gtgagccctc acagatggag caatggggcg cgcacacctg aacaagggag    300

gggaaggagt tcttatccct gatgcatgtg acccctgctg ctgtgtcctt cccctattgg    360

ctaaggcttc tgacagcttt ggagattgtg acattggaat aaaggaaaaa cgtacaggac    420

tcatgaagcg ctgaaatgtt cacaaatatc aagcaaaagt caatgaaatt tattttgagc    480

tatttacatc atttaataat tgagcaaggt atactcctat gaacaaaatt tggagcatgt    540

ttgtctctct ctgcctggcg tcttcagaat ttggaaacta gttatggttt ataatcagct    600

atagaatttt aacacgtgct ctcaaatgca agtttctgat aactttggag attgtgacat    660

tggaataaag gaagagctgg aatgttcatg aatatcaagc aaaagtcatg gaaatttatt    720

ttgagctatt tacagcattt aataattgag caaggtatac tcctatgaac aaaatttgga    780

gcatgtttgt ctctctctgt ctgcctggca tctacagaat ttggaaacta gtttcgttcc    840

cagatttcct aaactttcca gagaaaatgg tcttctccct ggctcagcaa gaagatgaac    900

tttaaacact gagaaactgg tcatctccct ggctcaacca gaagatgaac tttaaacact    960

actctcaatg acttgatgtt cccatcacta ctcctgtcat aaagggaggg gactcagata   1020

ttgagaattt tatgatagtg tgaactgtct ggtatgtcat ttaagtaagc ccgttgctga   1080

aatattttcc atgttattag aaagagctga agagagggat tgagatggct tctttatttt   1140

ttgtcttttg ggaattaaag gaacctggtt caacaagggc ctacacctaa gtctcttgtt   1200

gtaccagagt acaatttagg actgctcctg aggaaggaat tagctagaaa tctagagagt   1260

aagggtaaca gatttacata gaataacagc ctcagtattt ttggttcctc tccagtaaag   1320

atcacaaaga atattgctaa atcgctaaaa cacctttgca ataacgtaag ggcttacaac   1380

tatataccaa tgtagctcag ttactaaact ggagtaaact aatttctctt gtgtagaaaa   1440

attggttggc tgtggtttta tagcagatct gcaattatta atagttatgc caataatcgt   1500

ttaacagtgc atatgttaat atatatggaa agacaatgtg tatagacaga tgtgtaaaat   1560

tgaaaaataa acatataaca agagagaaac atctatcgaa cagacaatat acatacacat   1620

caaacacaac agcagtttta gtgaccataa tatttatttc tcatttttac attgcttact   1680

ttagtgacaa ctgaaaatga cagttggcaa tgcagctaac agtttcaata aaagtataaa   1740

acaaaagact gtgtacaaag cacctgtctt tccgcttttg taatcttccg ttggaaaaaa   1800

tttacacacc taagtaacca tctgttttct tcaagaaaaa atcattctta tttctctctc   1860

tcatcttgaa aacagctgtc agccaggagg gcagagctga aatttattgc cacatcacat   1920

gaagcataga acagactcca ctactccttg agattcaaaa ctttgcctct cacaaagtta   1980

ccttttattt tcctcttgtt tgtcactcat ctcccctagt gtgctctttt tatttctttt   2040

actattaata ataaaatctg tggatgactg tattatt                            2077


<210>  3552
<211>  53
<212>  PRT
<213>  Homo sapiens

<400>  3552


Met Gly Arg Ala His Leu Asn Lys Gly Gly Glu Gly Val Leu Ile Pro 
1               5                   10                  15      


Asp Ala Cys Asp Pro Cys Cys Cys Val Leu Pro Leu Leu Ala Lys Ala 
            20                  25                  30          


Ser Asp Ser Phe Gly Asp Cys Asp Ile Gly Ile Lys Glu Lys Arg Thr 
        35                  40                  45              


Gly Leu Met Lys Arg 
    50              

<210>  3553
<211>  1957
<212>  DNA
<213>  Homo sapiens

<400>  3553
aagtttgaag gattcagagc agagaattgc accctggcat gatgcctatg ccagctggac     60

tgtgtgattt ttgttcttta gtagaaggat aacatgacat agcaggaata atactgcctt    120

ttctttctgg catggatcaa gagaaaagaa aatacaagaa aacagacaga agatcctatc    180

tgcgacaatt aagagcactc taagaggaaa acacatccca ccacacaagg caaggtactt    240

ctatggaagg gtgagccctc acagatggag caatggggcg cgcacacctg aacaagggag    300

gggaaggagt tcttatccct gatgcatgtg acccctgctg ctgtgtcctt cccctattgg    360

ctaaggcttc tgacagcttt ggagattgtg acattggaat aaaggaaaaa cgtacaggac    420

tcatgaagcg ctgaaatgtt cacaaatatc aagcaaaagt caatgaaatt tattttgagc    480

tatttacatc atttaataat tgagcaaggt atactcctat gaacaaaatt tggagcatgt    540

ttgtctctct ctgcctggcg tcttcagaat ttggaaacta gttagtcatg gaaatttatt    600

ttgagctatt tacagcattt aataattgag caaggtatac tcctatgaac aaaatttgga    660

gcatgtttgt ctctctctgt ctgcctggca tctacagaat ttggaaacta gtttcgttcc    720

cagatttcct aaactttcca gagaaaatgg tcttctccct ggctcagcaa gaagatgaac    780

tttaaacact gagaaactgg tcatctccct ggctcaacca gaagatgaac tttaaacact    840

actctcaatg acttgatgtt cccatcacta ctcctgtcat aaagggaggg gactcagata    900

ttgagaattt tatgatagtg tgaactgtct ggtatgtcat ttaagtaagc ccgttgctga    960

aatattttcc atgttattag aaagagctga agagagggat tgagatggct tctttatttt   1020

ttgtcttttg ggaattaaag gaacctggtt caacaagggc ctacacctaa gtctcttgtt   1080

gtaccagagt acaatttagg actgctcctg aggaaggaat tagctagaaa tctagagagt   1140

aagggtaaca gatttacata gaataacagc ctcagtattt ttggttcctc tccagtaaag   1200

atcacaaaga atattgctaa atcgctaaaa cacctttgca ataacgtaag ggcttacaac   1260

tatataccaa tgtagctcag ttactaaact ggagtaaact aatttctctt gtgtagaaaa   1320

attggttggc tgtggtttta tagcagatct gcaattatta atagttatgc caataatcgt   1380

ttaacagtgc atatgttaat atatatggaa agacaatgtg tatagacaga tgtgtaaaat   1440

tgaaaaataa acatataaca agagagaaac atctatcgaa cagacaatat acatacacat   1500

caaacacaac agcagtttta gtgaccataa tatttatttc tcatttttac attgcttact   1560

ttagtgacaa ctgaaaatga cagttggcaa tgcagctaac agtttcaata aaagtataaa   1620

acaaaagact gtgtacaaag cacctgtctt tccgcttttg taatcttccg ttggaaaaaa   1680

tttacacacc taagtaacca tctgttttct tcaagaaaaa atcattctta tttctctctc   1740

tcatcttgaa aacagctgtc agccaggagg gcagagctga aatttattgc cacatcacat   1800

gaagcataga acagactcca ctactccttg agattcaaaa ctttgcctct cacaaagtta   1860

ccttttattt tcctcttgtt tgtcactcat ctcccctagt gtgctctttt tatttctttt   1920

actattaata ataaaatctg tggatgactg tattatt                            1957


<210>  3554
<211>  53
<212>  PRT
<213>  Homo sapiens

<400>  3554


Met Gly Arg Ala His Leu Asn Lys Gly Gly Glu Gly Val Leu Ile Pro 
1               5                   10                  15      


Asp Ala Cys Asp Pro Cys Cys Cys Val Leu Pro Leu Leu Ala Lys Ala 
            20                  25                  30          


Ser Asp Ser Phe Gly Asp Cys Asp Ile Gly Ile Lys Glu Lys Arg Thr 
        35                  40                  45              


Gly Leu Met Lys Arg 
    50              

<210>  3555
<211>  1737
<212>  DNA
<213>  Homo sapiens

<400>  3555
aagtttgaag gattcagagc agagaattgc accctggcat gatgcctatg ccagctggac     60

tgtgtgattt ttgttcttta gtagaaggat aacatgacat agcaggaata atactgcctt    120

ttctttctgg catggatcaa gagaaaagaa aatacaagaa aacagacaga agatcctatc    180

tgcgacaatt aagagcactc taagaggaaa acacatccca ccacacaagg caaggtactt    240

ctatggaagg gtgagccctc acagatggag caatggggcg cgcacacctg aacaagggag    300

gggaaggagt tcttatccct gatgcatgtg acccctgctg ctgtgtcctt cccctattgg    360

ctaaggcttc tgacagcttt ggagattgtg acattggaat aaaggaaaaa cgtacaggac    420

tcatgaagcg ctgaaatgtt cacaaatatc aagcaaaagt caatgaaatt tattttgagc    480

tatttacatc atttaataat tgagcaaggt atactcctat gaacaaaatt tggagcatgt    540

ttgtctctct ctgcctggcg tcttcagaat ttggaaacta gttatggttt ataatcagct    600

atagaatttt aacacgtgct ctcaaatgca agtttctgat aactttggag attgtgacat    660

tggaataaag gaagagctgg aatgttcatg aatatcaagc aaaagtcatg gaaatttatt    720

ttgagctatt tacagcattt aataattgag caaggtatac tcctatgaac aaaatttgga    780

gcatgtttgt ctctctctgt ctgcctggca tctacagaat ttggaaacta gtttcgttcc    840

cagatttcct aaactttcca gagaaaatgg tcttctccct ggctcagcaa gaagatgaac    900

tttaaacact gagaaactgg tcatctccct ggctcaacca gaagatgaac tttaaacact    960

actctcaatg acttgatgtt cccatcacta ctcctgtcat aaagggaggg gactcagata   1020

ttgagaattt tatgatagtg tgaactgtct ggtatgtcat ttaagtaagc ccgttgctga   1080

aatattttcc atgttattag aaagagctga agagagggat tgagatggct tctttatttt   1140

ttgtcttttg ggaattaaag gaacctggtt caacaagggc ctacacctaa gtctcttgtt   1200

gtaccagagt acaatttagg actgctcctg aggaaggaat tagctagaaa tctagagagt   1260

aagggtaaca gatttacata gaataacagc ctcagtattt ttggttcctc tccagtaaag   1320

atcacaaaga atattgctaa atcgctaaaa cacctttgca ataacgtaag ggcttacaac   1380

tatataccaa tgtagctcag ttactaaact ggagtaaact aatttctctt gtgtagaaaa   1440

attggttggc tgtggtttta tagcagatct gcaattatta atagttatgc caataatcgt   1500

ttaacagtgc atatgttaat atatatggaa agacaatgtg tatagacaga tgtgtaaaat   1560

tgaaaaataa acatataaca agagagaaac atctatcgaa cagacaatat acatacacat   1620

caaacacaac agcagtttta gtgaccataa tatttatttc tcatttttac attgcttact   1680

ttagtgacaa ctgaaaatga cagttggcaa tgcagctaac agtttcaata aaagtat      1737


<210>  3556
<211>  53
<212>  PRT
<213>  Homo sapiens

<400>  3556


Met Gly Arg Ala His Leu Asn Lys Gly Gly Glu Gly Val Leu Ile Pro 
1               5                   10                  15      


Asp Ala Cys Asp Pro Cys Cys Cys Val Leu Pro Leu Leu Ala Lys Ala 
            20                  25                  30          


Ser Asp Ser Phe Gly Asp Cys Asp Ile Gly Ile Lys Glu Lys Arg Thr 
        35                  40                  45              


Gly Leu Met Lys Arg 
    50              

<210>  3557
<211>  2452
<212>  DNA
<213>  Homo sapiens

<400>  3557
gatgcttttt ttctcttaga ccaaagcagg agcagtgatt agtttaggtt cagggaaatc     60

ggaccatctg caacatccct attacacaga tattccccct tgtctgtggc taaaactctc    120

aggcaagctt tggcatgaga atctatttca ttttgctata accatatttt ctttttttaa    180

tttgctaatt agtctactac ctaaatttcc acttaattat catgaaaata atgtggaata    240

acttgtagaa tattttgtat aggcttctca tagtcttctc aatttcaact attttaagat    300

tttaattatt ctgattttaa aataatttgc agttatttgt gtgattactt gtgtaatttt    360

taaaagttac ttacaccaga aaaatataag cactgttgtt attttgatgt ttttctaata    420

ttaatatgca tatatcatag gaagtattta aatgaatttt aatttccctt ttcaatcatc    480

tcccattgaa agctgaatca tgaggatacc atctccaagc aggtggagta tttgatccct    540

ttagcaaggc agtgattttg aaattcgggt ttagacaaaa agatatttca agctcctgaa    600

gaacaagttt gaaggattca gagcagagaa ttgcaccctg gcatgatgcc tatgccagct    660

ggactgtgtg atttttgttc tttagtagaa ggataacatg acatagcagg aataatactg    720

ccttttcttt ctggcatgga tcaagagaaa agaaaataca agaaaacaga cagaagcaag    780

gcaaggtact tctatggaag ggtgagccct cacagatgga gcaatggggc gcgcacacct    840

gaacaaggga ggggaaggag ttcttatccc tgatgcatgt gacccctgct gctgtgtcct    900

tcccctattg gctaaggtta gaccacacag cctaaactaa ttccgattgg ctaattcaaa    960

gagagcgacg ggggcttctg acagctttgg agattgtgac attggaataa aggaaaaacg   1020

tacaggactc atgaagcgct gaaatgttca caaatatcaa gcaaaagtca atgaaattta   1080

ttttgagcta tttacatcat ttaataattg agcaaggtat actcctatga acaaaatttg   1140

gagcatgttt gtctctctct gcctggcgtc ttcagaattt ggaaactagt tatggtttat   1200

aatcagctat agaattttaa cacgtgctct caaatgcaag tttctgataa ctttggagat   1260

tgtgacattg gaataaagga agagctggaa tgttcatgaa tatcaagcaa aagtcatgga   1320

aatttatttt gagctattta cagcatttaa taattgagca aggtatactc ctatgaacaa   1380

aatttggagc atgtttgtct ctctctgtct gcctggcatc tacagaattt ggaaactagt   1440

tgtgctgtac tgcatgagaa tgcctgcatt tagtatgcga actggaattg gcaaaggacg   1500

atggctgctc tcccgctaac tttaaataag tcatgtcaca aattgcattc gttcccagat   1560

ttcctaaact ttccagagaa aatggtcttc tccctggctc agcaagaaga tgaactttaa   1620

acactgagaa actggtcatc tccctggctc aaccagaaga tgaactttaa acactactct   1680

caatgacttg atgttcccat cactactcct gtcataaagg gaggggactc agatattgag   1740

aattttatga tagtgtgaac tgtctggtat gtcatttaag taagcccgtt gctgaaatat   1800

tttccatgtt attagaaaga gctgaagaga gggattgaga tggcttcttt attttttgtc   1860

ttttgggaat taaaggaacc tggttcaaca agggcctaca cctaagtctc ttgttgtacc   1920

agagtacaat ttaggactgc tcctgaggaa ggaattagct agaaatctag agagtaaggg   1980

taacagattt acatagaata acagcctcag tatttttggt tcctctccag taaagatcac   2040

aaagaatatt gctaaatcgc taaaacacct ttgcaataac gtaagggctt acaactatat   2100

accaatgtag ctcagttact aaactggagt aaactaattt ctcttgtgta gaaaaattgg   2160

ttggctgtgg ttttatagca gatctgcaat tattaatagt tatgccaata atcgtttaac   2220

agtgcatatg ttaatatata tggaaagaca atgtgtatag acagatgtgt aaaattgaaa   2280

aataaacata taacaagaga gaaacatcta tcgaacagac aatatacata cacatcaaac   2340

acaacagcag ttttagtgac cataatattt atttctcatt tttacattgc ttactttagt   2400

gacaactgaa aatgacagtt ggcaatgcag ctaacagttt caataaaagt at           2452


<210>  3558
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  3558


Met Asn Lys Ile Trp Ser Met Phe Val Ser Leu Cys Leu Pro Gly Ile 
1               5                   10                  15      


Tyr Arg Ile Trp Lys Leu Val Val Leu Tyr Cys Met Arg Met Pro Ala 
            20                  25                  30          


Phe Ser Met Arg Thr Gly Ile Gly Lys Gly Arg Trp Leu Leu Ser Arg 
        35                  40                  45              

<210>  3559
<211>  2278
<212>  DNA
<213>  Homo sapiens

<400>  3559
gatgcttttt ttctcttaga ccaaagcagg agcagtgatt agtttaggtt cagggaaatc     60

ggaccatctg caacatccct attacacaga tattccccct tgtctgtggc taaaactctc    120

aggcaagctt tggcatgaga atctatttca ttttgctata accatatttt ctttttttaa    180

tttgctaatt agtctactac ctaaatttcc acttaattat catgaaaata atgtggaata    240

acttgtagaa tattttgtat aggcttctca tagtcttctc aatttcaact attttaagat    300

tttaattatt ctgattttaa aataatttgc agttatttgt gtgattactt gtgtaatttt    360

taaaagttac ttacaccaga aaaatataag cactgttgtt attttgatgt ttttctaata    420

ttaatatgca tatatcatag gaagtattta aatgaatttt aatttccctt ttcaatcatc    480

tcccattgaa agctgaatca tgaggatacc atctccaagc aggtggagta tttgatccct    540

ttagcaaggc agtgattttg aaattcgggt ttagacaaaa agatatttca agctcctgaa    600

gaacaagttt gaaggattca gagcagagaa ttgcaccctg gcatgatgcc tatgccagct    660

ggactgtgtg atttttgttc tttagtagaa ggataacatg acatagcagg aataatactg    720

ccttttcttt ctggcatgga tcaagagaaa agaaaataca agaaaacaga cagaagatcc    780

tatctgcgac aattaagagc actctaagag gaaaacacat cccaccacac aaggcaaggt    840

acttctatgg aagggtgagc cctcacagat ggagcaatgg ggcgcgcaca cctgaacaag    900

ggaggggaag gagttcttat ccctgatgca tgtgacccct gctgctgtgt ccttccccta    960

ttggctaagg ttagaccaca cagcctaaac taattccgat tggctaattc aaagagagcg   1020

acgggggctt ctgacagctt tggagattgt gacattggaa taaaggaaaa acgtacagga   1080

ctcatgaagc gctgaaatgt tcacaaatat caagcaaaag tcaatgaaat ttattttgag   1140

ctatttacat catttaataa ttgagcaagg tatactccta tgaacaaaat ttggagcatg   1200

tttgtctctc tctgcctggc gtcttcagaa tttggaaact agttagtcat ggaaatttat   1260

tttgagctat ttacagcatt taataattga gcaaggtata ctcctatgaa caaaatttgg   1320

agcatgtttg tctctctctg tctgcctggc atctacagaa tttggaaact agtttcgttc   1380

ccagatttcc taaactttcc agagaaaatg gtcttctccc tggctcagca agaagatgaa   1440

ctttaaacac tgagaaactg gtcatctccc tggctcaacc agaagatgaa ctttaaacac   1500

tactctcaat gacttgatgt tcccatcact actcctgtca taaagggagg ggactcagat   1560

attgagaatt ttatgatagt gtgaactgtc tggtatgtca tttaagtaag cccgttgctg   1620

aaatattttc catgttatta gaaagagctg aagagaggga ttgagatggc ttctttattt   1680

tttgtctttt gggaattaaa ggaacctggt tcaacaaggg cctacaccta agtctcttgt   1740

tgtaccagag tacaatttag gactgctcct gaggaaggaa ttagctagaa atctagagag   1800

taagggtaac agatttacat agaataacag cctcagtatt tttggttcct ctccagtaaa   1860

gatcacaaag aatattgcta aatcgctaaa acacctttgc aataacgtaa gggcttacaa   1920

ctatatacca atgtagctca gttactaaac tggagtaaac taatttctct tgtgtagaaa   1980

aattggttgg ctgtggtttt atagcagatc tgcaattatt aatagttatg ccaataatcg   2040

tttaacagtg catatgttaa tatatatgga aagacaatgt gtatagacag atgtgtaaaa   2100

ttgaaaaata aacatataac aagagagaaa catctatcga acagacaata tacatacaca   2160

tcaaacacaa cagcagtttt agtgaccata atatttattt ctcattttta cattgcttac   2220

tttagtgaca actgaaaatg acagttggca atgcagctaa cagtttcaat aaaagtat     2278


<210>  3560
<211>  46
<212>  PRT
<213>  Homo sapiens

<400>  3560


Met Asn Lys Ile Trp Ser Met Phe Val Ser Leu Cys Leu Pro Gly Ile 
1               5                   10                  15      


Tyr Arg Ile Trp Lys Leu Val Ser Phe Pro Asp Phe Leu Asn Phe Pro 
            20                  25                  30          


Glu Lys Met Val Phe Ser Leu Ala Gln Gln Glu Asp Glu Leu 
        35                  40                  45      

<210>  3561
<211>  978
<212>  DNA
<213>  Homo sapiens

<400>  3561
aagtttgaag gattcagagc agagaattgc accctggcat gatgcctatg ccagctggac     60

tgtgtgattt ttgttcttta gtagaaggat aacatgacat agcaggaata atactgcctt    120

ttctttctgg catggatcaa gagaaaagaa aatacaagaa aacagacaga agcaaggcaa    180

ggtacttcta tggaagggtg agccctcaca gatggagcaa tggggcgcgc acacctgaac    240

aagggagggg aaggagttct tatccctgat gcatgtgacc cctgctgctg tgtccttccc    300

ctattggcta aggcttctga cagctttgga gattgtgaca ttggaataaa ggaaaaacgt    360

acaggactca tgaagcgctg aaatgttcac aaatatcaag caaaagtcaa tgaaatttat    420

tttgagctat ttacatcatt taataattga gcaaggtata ctcctatgaa caaaatttgg    480

agcatgtttg tctctctctg cctggcgtct tcagaatttg gaaactagtt agtcatggaa    540

atttattttg agctatttac agcatttaat aattgagcaa ggtatactcc tatgaacaaa    600

atttggagca tgtttgtctc tctctgtctg cctggcatct acagaatttg gaaactagtt    660

gatgcaattg gagaaactgg ttgttttacc aaggctttga ctggaaggat atgcttccct    720

ttaagaaacc aagctcaact tacagagctg ataaaacccc tttgggaaaa ctggcctcat    780

accttgtcta cacagtcccc atgcagggtt cctaacgtgt gtcgttccca gatttcctaa    840

actttccaga gaaaatggtc ttctccctgg ctcagcaaga agatgaactt taaacactga    900

gaaactggtc atctccctgg ctcaaccaga agatgaactt taaacactac tctcaatgac    960

ttgatgttcc catcacta                                                  978


<210>  3562
<211>  82
<212>  PRT
<213>  Homo sapiens

<400>  3562


Met Asn Lys Ile Trp Ser Met Phe Val Ser Leu Cys Leu Pro Gly Ile 
1               5                   10                  15      


Tyr Arg Ile Trp Lys Leu Val Asp Ala Ile Gly Glu Thr Gly Cys Phe 
            20                  25                  30          


Thr Lys Ala Leu Thr Gly Arg Ile Cys Phe Pro Leu Arg Asn Gln Ala 
        35                  40                  45              


Gln Leu Thr Glu Leu Ile Lys Pro Leu Trp Glu Asn Trp Pro His Thr 
    50                  55                  60                  


Leu Ser Thr Gln Ser Pro Cys Arg Val Pro Asn Val Cys Arg Ser Gln 
65                  70                  75                  80  


Ile Ser 
        

<210>  3563
<211>  903
<212>  DNA
<213>  Homo sapiens

<400>  3563
aagtttgaag gattcagagc agagaattgc accctggcat gatgcctatg ccagctggac     60

tgtgtgattt ttgttcttta gtagaaggat aacatgacat agcaggaata atactgcctt    120

ttctttctgg catggatcaa gagaaaagaa aatacaagaa aacagacaga agcaaggcaa    180

ggtacttcta tggaagggtg agccctcaca gatggagcaa tggggcgcgc acacctgaac    240

aagggagggg aaggagttct tatccctgat gcatgtgacc cctgctgctg tgtccttccc    300

ctattggcta aggcttctga cagctttgga gattgtgaca ttggaataaa ggaaaaacgt    360

acaggactca tgaagcgctg aaatgttcac aaatatcaag caaaagtcaa tgaaatttat    420

tttgagctat ttacatcatt taataattga gcaaggtata ctcctatgaa caaaatttgg    480

agcatgtttg tctctctctg cctggcgtct tcagaatttg gaaactagtt aaaattgttg    540

tcttattttc atcctcttta aaagatggtt tataatcagc tatagaattt taacacgtgc    600

tctcaaatgc aagtttctga taactttgga gattgtgaca ttggaataaa ggaagagctg    660

gaatgttcat gaatatcaag caaaagtcat ggaaatttat tttgagctat ttacagcatt    720

taataattga gcaaggtata ctcctatgaa caaaatttgg agcatgtttg tctctctctg    780

tctgcctggc atctacagaa tttggaaact agtttcgttc ccagatttcc taaactttcc    840

agagaaaatg gtcttctccc tggctcagca agaagatgaa ctttaaacac tgagaaactg    900

gtc                                                                  903


<210>  3564
<211>  53
<212>  PRT
<213>  Homo sapiens

<400>  3564


Met Gly Arg Ala His Leu Asn Lys Gly Gly Glu Gly Val Leu Ile Pro 
1               5                   10                  15      


Asp Ala Cys Asp Pro Cys Cys Cys Val Leu Pro Leu Leu Ala Lys Ala 
            20                  25                  30          


Ser Asp Ser Phe Gly Asp Cys Asp Ile Gly Ile Lys Glu Lys Arg Thr 
        35                  40                  45              


Gly Leu Met Lys Arg 
    50              

<210>  3565
<211>  4486
<212>  DNA
<213>  Homo sapiens

<400>  3565
tcaagatagg ttgaaagggg agttcgtagt catctcttct aatcaggaga tccctgaaag     60

ccgaacattt aaatgttctc ttcttgaaat aaaaatacca tagttttagt taggaatgtg    120

ctatgttgaa aataacagaa aaactgacct ctgtggctta aacaagtaag gatttatttt    180

ccttccgtag ctggaggaag ggaggtgcag ctttggctca gctcttaaca gtgcaacatc    240

tagtgcctct atagttctct tggacacaga tggctgcttt cgaagaagaa agaagtggaa    300

agtgatggag tttctatgct ccagctctct ttgcctgctg ccatccacgt aagatgtgac    360

ttgctcctct ttgccttctg ccataattgt gagcccccct cagccatgtg gaatggccca    420

cagccaagcc attgagagac aagtccatgg gagacaaatt agctcatgca gctgagatgt    480

cctggagatt ttccacagca ccacttggcc agtgcctaga caagaggcca tctttgaaga    540

agtaaacaag taccatacac taaagggatg acagaacaac gaaacaaaag gcttccgagg    600

cgatccggca acatcagtct tcagccgcta agccaagaag atctgggaag gagtcaatca    660

gagagccttg ggccagagtt ccaggggctg tggaagtggc tgccagggtg tggtgacgca    720

acctgtagtc ccagcacttc gggaggccga ggtggcagat cactcgagct caggagttca    780

agagcagcct ggcaaaatcc cgtgactcca gaagtatgaa aattagccgg gcgtggtggc    840

gcacacctgt agtcctagct acttgggagg ctgaggtggg aggattgcgt gagctcggga    900

ggttaaggct gcagtgagct gagatcgcac caccacactg cggtctgggt gacagagtga    960

gatcctgtct caaaaaacaa aataaaatat aacaaaactg gtatagacat tcatatgtag   1020

gtttttgtat ggatttggta tgatttttat tgttaaagtt tagtttttat gttttagagt   1080

tatatatata tatgaatcat ttaatttgta tgcttatgtg tttggctcct tttcctcagc   1140

ataatgtttt aagattcctc tatgaatcag ttgcatatat caggagtttt ttcttatagt   1200

tcagtaatat tccattatgt gaatatagta taatttcttt atctcttcag ctgttaatgg   1260

acatttaggg tgttcagttt ggggatattt gaaatgttat gaacattttt gtacagatct   1320

tatgatacat acatttttat ttttcttatc agaatgatat tactgagtca tgtgatattt   1380

ttatttttaa cattatgtaa actgttttaa atagaacaat tgttttccaa agtagctgtg   1440

ctatttatac cttcagtcaa aatatacaaa agtttcttgt tactgcacat aatctccaac   1500

agaaaggact tatggtaaat ctttaacaaa ttttagtcat tctactccct gttggtggta   1560

tctttttgtg gtatttttga aagaaattga cttttattga gatatgattt acatataatt   1620

aaatgaccac attaagagta cactttgata agttttgcta actgtacata tcaatgtaac   1680

caccacaatt gaaaattaga tcttttttat cttctcaaag tgttccttta tgctcttctg   1740

tagacaatct tccccagtcc tcaacacagg caccaatgga tatgaattca gtcattgtcg   1800

actggtgttc tgcctgtcct agatgtcacg taaatggatt caaatagatg tgtgctcttg   1860

tgtctgactc cttttgttca gcgtggtgct tttgagattt atctgtgtca tttggggtat   1920

cagtaattca tatcttttat ttccaactag ggttgtgtga ttataccaca atgtcttttg   1980

caaattagtt gtttcatttt atatatttta tatgtatcag cagtttatga gttataaata   2040

acttttcttt ataaattacc cagtttcagg tagttctttg gtggtgtttt cctgttgctc   2100

tccgttctaa cacctgatat tgttggtctt acttttagcc attttagtac tagatgctcc   2160

ccgactcacg atggggttat gccccaataa atccattgtt aagttgaaaa tatcacaagt   2220

tgaaaatgca tttttaatac actttaacta tcaaacgtca tagcttagcc tagcctacct   2280

taaacaggct cacaacactt acattattct acacttgagc aaaatcatct ggcaacacag   2340

caaactgtag agtatctctt gtttactctg gtgatcttgt ggctgactgg aagccttagc   2400

tccctgccac tgtccaacat cccaagaggg ttttctactg ctttctactg aatgtgtatt   2460

gcttttgcac cattttaaag taaaaaaagt tatatgtcaa atcatcaaaa gttgttttga   2520

tgagattttc tgtttgtgta gtaatatttc actttagtta taatttctgt atacctgaca   2580

gccaattata ttgtgtatgt ttatatttat ttacttattt cataccttct tgtatgaaat   2640

tgttgtccaa attttttgtc cagtttctaa atcacagttt actttctcat tattaatatg   2700

ttttttattt ttatttttta ttatttttgt ttttagacgg agtctcttct ctgtcgccca   2760

ggctcgagtg cagtggcgca atctctgctc actgcaagct ccgcctcctg ggttcacgcc   2820

attctcctgc ctcagcctcc cgagtagctg ggactacagg cgcccgccac cacacctggc   2880

taagttttgt atttttttag tagagacggg gtttcaccgt ggtctacatc tcctgacctc   2940

gtgatctgcc cgcctcggcc tcccaaagtg ctgggattac aggcgtgagc caccgcaccc   3000

ggccaagttt tttcttttgt aaaatttgaa tatataagtc ccatataagg tcaatttatt   3060

cttttttctc gcatggtcag tgctatacaa gatgataaag atatatgcct accttttctt   3120

ttgttaagtt tatatttcag ctcatatgtt aaatctataa tccattttga gttaattttg   3180

tagatggggt gaggtaagaa tagatacaca acttttaggc tgatattcag ttgtcctagc   3240

actagtttat tgaagatact tttttcccca ttaaatgtcc ttgaactttt tcaaaaaagc   3300

aattgactat atgtgtttgg gtgttgatac agtttgagtc tgtgtcccca cccaaatcat   3360

gtcaaattga aatccccaat gttggaggtg gggcctggtg gggagtgatt ggttcatggg   3420

gacagatttt ccctttggtg ttgttgttat gacagcgagt gagttatgag atctggttgt   3480

tcaaaagtgt gtaacacctc cccactctct cttcctcctg ctctggccat gtaagacgtg   3540

actgcttgcc cttcaccttc cgtcatggtt gaaagtttcc tgaggtctcc ccaaacatgc   3600

ttcccataca gcttcccaac tgtgaacaaa tgaaatctct tttctttata aattacccag   3660

tttcaggtag ttctttacag tagtgaggga acagactaat acagttatat cctgttccat   3720

cttttttcta atgctttgct gcattgtctt ataacacagc tttataatct taaaatcata   3780

acctgtaggc cctcaaaatc ttttcttttt aaaaattatt ttggctattg aaggtccttt   3840

gtgtttccgt ataaatttga caattgtctg gttgatttcc tcaaaaattc ttttggcttc   3900

caaaatttga aagcagccta agtgttatca agaattgaat ggataaataa aatgcagtac   3960

agatacacaa tggagtacta ttcagcaata gaaagaatga aatcctgtca tttgcaacaa   4020

catggatgga actggaggtc attatgttaa gtgaaataag ccatacacag aaagacaaac   4080

ttcatatatt ctcacttttt tgcgagagct aaaaattaaa acaattgaac tcatggagat   4140

ggagaataga ttgatggtta ccagaggctt ggaaggatag tgggagtggg gaatgtggat   4200

ggttaatggg tacaaaaata caggtttata gggttaatac ctgttgatac aacaacatgg   4260

tagctacagc caacaataat ttatcataca tttaaaaata accaaaacag tataattgaa   4320

atatttgtaa cacaaggaaa atgataagta cctgaggtga cgggtaccct atttaccctg   4380

atgtgattat tacacattgt atgtctgtat caaaatatct caggtactga taaatgcata   4440

cacctactat gtacccataa aaatcaaaaa ttaaaaatta aacaac                  4486


<210>  3566
<211>  83
<212>  PRT
<213>  Homo sapiens

<400>  3566


Met Thr Glu Gln Arg Asn Lys Arg Leu Pro Arg Arg Ser Gly Asn Ile 
1               5                   10                  15      


Ser Leu Gln Pro Leu Ser Gln Glu Asp Leu Gly Arg Ser Gln Ser Glu 
            20                  25                  30          


Ser Leu Gly Pro Glu Phe Gln Gly Leu Trp Lys Trp Leu Pro Gly Cys 
        35                  40                  45              


Gly Asp Ala Thr Cys Ser Pro Ser Thr Ser Gly Gly Arg Gly Gly Arg 
    50                  55                  60                  


Ser Leu Glu Leu Arg Ser Ser Arg Ala Ala Trp Gln Asn Pro Val Thr 
65                  70                  75                  80  


Pro Glu Val 
            

<210>  3567
<211>  2853
<212>  DNA
<213>  Homo sapiens

<400>  3567
agccacgtgg cctcgttcct gttccccttc cctaccctgc aggactcgcc tccacacttg     60

tgatgtctcc tgaagataac tccggttgga agtttcttct acctgaaatg aaaccataac    120

ccctgcagca tccacttggg gtgccagagt cccacctcca gcacagtctt cattactggc    180

catggcaggg aggagtacag aatgggcagg cccaggacag ctggcccatc agaccattag    240

aaacagcgag tccggagttc caggggcttg tccacggcca cacagcagcc cgtggcccca    300

ggaagccaaa gctcccagcc agtcatccag tggtgggggg tttagttcca gggggccaga    360

ggtcctctgc ggaagagagt gcaaggcagt atccgcggca ggcccagaga ggccaggaca    420

ggtcagaaag gcctacccct ctttcgcttg gtaccctttc ctctttgcga gggatgcaaa    480

ggttatttat acttcgggtc tgcaggctgc gggtggggca ggcaccccgc ctggggcggg    540

ttgcgggcgc aggggcagga atgggcttac ctgcttcccg ccaccggggc tgggcggggc    600

gctgcgggga ggaggagccg ggcacaacct gtggacggcc gcggccggcg gacacacagc    660

agcgggggcc cggccggggg tcgcccgggg gcccggaagc cggggaagag cgaggaaacc    720

aacttggaga gaggagtgac ctgggggccg ggggcggagt cgtgagcggg ggaggagaga    780

gccggccgcc agcaagagcc gcgcggcggc ccaggaagcg agagcgccgc ccacccatcc    840

ggggcaagag ccgcgccgca ggagaggcag gctggaccgg gggctccccg ggcccgcgac    900

ccccgccgtg accccgcagc ccccagctcg cccccaagat gatgaagagg cagctgcacc    960

gcatgcggca gctggcccag acgggcagct tgggacgcac cccggagacc gctgagttcc   1020

tgggtgagga cctgctgcag gtagaacagc ggctggagcc ggccaagcgg gcagcccaca   1080

acatccacaa gcggctgcag gcctgtctgc agggccagag cggggcagac atggacaagc   1140

gggtgaagaa gcttcccctc atggctctgt ccaccacgat ggctgagagc ttcaaggagc   1200

tggaccctga ttccagcatg gggaaggcct tggagatgag ctgtgccatc cagaatcagc   1260

tggcccgcat cctggccgag tttgagatga ccctggagag ggacgtcctg cagccactca   1320

gcaggctgag tgaggaggag ctgccagcca tcctcaaaca caagaaaagc ctccagaagc   1380

tcgtgtccga ctggaacaca ctcaagagca ggctcagtca ggcaaccaag aattcaggca   1440

gcagtcaagg cctaggaggc agcccgggta gtcacagcca tacgaccatg gccaacaagg   1500

tggagacgct gaaggaggag gaggaggagc tgaagaggaa agtggagcaa tgcagggacg   1560

agtacttggc tgacctgtac cactttgtta ccaaggagga ctcctatgcc aactacttca   1620

ttcgtctcct ggagattcag gccgattacc atcgcaggtc actgagctcg ctggacacag   1680

ccctggctga gctgagggag aaccacggcc aagcagacca ctccccttcg atgacagcca   1740

cccacttccc cagggtgtat ggggtgtcgc tggcaaccca cctgcaagag ctgggccggg   1800

agattgccct gcccatcgag gcctgcgtca tgatgctgct ttctgagggc atgaaggaag   1860

agggtctctt ccgtctggct gctggggcct cggtgctgaa gcgtctcaag cagacaatgg   1920

cctcggaccc ccacagcctg gaggagttct gctccgaccc gcacgctgtg gcaggtgccc   1980

tcaagtccta tctgcgggag ctgccagagc ctctgatgac cttcgacctc tatgatgact   2040

ggatgagggc agccagcctg aaggagccag gggcccggct gcaggccctc caagaggtgt   2100

gcagccgcct accccccgag aacctcagca acctcaggta cctgatgaag ttcctggcac   2160

ggctggccga ggagcaggag gtgaacaaga tgacacccag caacatcgcc atagtcctgg   2220

gacccaactt gctgtggcca cctgagaaag aaggagccag ccagagagtt ggggtcacaa   2280

accctttgct gagcagatgc atctctttgt cccagggacc aggcccagct ggatgcagcc   2340

tccgtgtctt ccatccaggt ggtgggcgtc gtcgaggcgc tgatccagag cgcagacacc   2400

ctcttccctg gagacatcaa cttcaacgtg tcaggcctct tctcagctgt taccctccag   2460

gacacagtca gtgacaggct ggcctctgag gaacttccgt ccactgccgt gcccacccca   2520

gccaccaccc cggctccggc tccggctcca gctccagctc cggccccagc cttggcttca   2580

gcagctacca aggaaaggac agagtctgag gtgcctccca gaccagcctc ccccaaggtc   2640

accaggagtc ccccggagac agctgcccca gtggaggaca tggctcggag gaccaagcgc   2700

ccggcgccag cccggcccac catgccgccc ccccaggtcc taggggagcc accggaagga   2760

aggagaggtt tgcctgctcc tacgggactg attcttctct tgccgacatg ttttttgtaa   2820

ggctggtaaa taaattattt tggacaaaac tgg                                2853


<210>  3568
<211>  511
<212>  PRT
<213>  Homo sapiens

<400>  3568


Met Met Lys Arg Gln Leu His Arg Met Arg Gln Leu Ala Gln Thr Gly 
1               5                   10                  15      


Ser Leu Gly Arg Thr Pro Glu Thr Ala Glu Phe Leu Gly Glu Asp Leu 
            20                  25                  30          


Leu Gln Val Glu Gln Arg Leu Glu Pro Ala Lys Arg Ala Ala His Asn 
        35                  40                  45              


Ile His Lys Arg Leu Gln Ala Cys Leu Gln Gly Gln Ser Gly Ala Asp 
    50                  55                  60                  


Met Asp Lys Arg Val Lys Lys Leu Pro Leu Met Ala Leu Ser Thr Thr 
65                  70                  75                  80  


Met Ala Glu Ser Phe Lys Glu Leu Asp Pro Asp Ser Ser Met Gly Lys 
                85                  90                  95      


Ala Leu Glu Met Ser Cys Ala Ile Gln Asn Gln Leu Ala Arg Ile Leu 
            100                 105                 110         


Ala Glu Phe Glu Met Thr Leu Glu Arg Asp Val Leu Gln Pro Leu Ser 
        115                 120                 125             


Arg Leu Ser Glu Glu Glu Leu Pro Ala Ile Leu Lys His Lys Lys Ser 
    130                 135                 140                 


Leu Gln Lys Leu Val Ser Asp Trp Asn Thr Leu Lys Ser Arg Leu Ser 
145                 150                 155                 160 


Gln Ala Thr Lys Asn Ser Gly Ser Ser Gln Gly Leu Gly Gly Ser Pro 
                165                 170                 175     


Gly Ser His Ser His Thr Thr Met Ala Asn Lys Val Glu Thr Leu Lys 
            180                 185                 190         


Glu Glu Glu Glu Glu Leu Lys Arg Lys Val Glu Gln Cys Arg Asp Glu 
        195                 200                 205             


Tyr Leu Ala Asp Leu Tyr His Phe Val Thr Lys Glu Asp Ser Tyr Ala 
    210                 215                 220                 


Asn Tyr Phe Ile Arg Leu Leu Glu Ile Gln Ala Asp Tyr His Arg Arg 
225                 230                 235                 240 


Ser Leu Ser Ser Leu Asp Thr Ala Leu Ala Glu Leu Arg Glu Asn His 
                245                 250                 255     


Gly Gln Ala Asp His Ser Pro Ser Met Thr Ala Thr His Phe Pro Arg 
            260                 265                 270         


Val Tyr Gly Val Ser Leu Ala Thr His Leu Gln Glu Leu Gly Arg Glu 
        275                 280                 285             


Ile Ala Leu Pro Ile Glu Ala Cys Val Met Met Leu Leu Ser Glu Gly 
    290                 295                 300                 


Met Lys Glu Glu Gly Leu Phe Arg Leu Ala Ala Gly Ala Ser Val Leu 
305                 310                 315                 320 


Lys Arg Leu Lys Gln Thr Met Ala Ser Asp Pro His Ser Leu Glu Glu 
                325                 330                 335     


Phe Cys Ser Asp Pro His Ala Val Ala Gly Ala Leu Lys Ser Tyr Leu 
            340                 345                 350         


Arg Glu Leu Pro Glu Pro Leu Met Thr Phe Asp Leu Tyr Asp Asp Trp 
        355                 360                 365             


Met Arg Ala Ala Ser Leu Lys Glu Pro Gly Ala Arg Leu Gln Ala Leu 
    370                 375                 380                 


Gln Glu Val Cys Ser Arg Leu Pro Pro Glu Asn Leu Ser Asn Leu Arg 
385                 390                 395                 400 


Tyr Leu Met Lys Phe Leu Ala Arg Leu Ala Glu Glu Gln Glu Val Asn 
                405                 410                 415     


Lys Met Thr Pro Ser Asn Ile Ala Ile Val Leu Gly Pro Asn Leu Leu 
            420                 425                 430         


Trp Pro Pro Glu Lys Glu Gly Ala Ser Gln Arg Val Gly Val Thr Asn 
        435                 440                 445             


Pro Leu Leu Ser Arg Cys Ile Ser Leu Ser Gln Gly Pro Gly Pro Ala 
    450                 455                 460                 


Gly Cys Ser Leu Arg Val Phe His Pro Gly Gly Gly Arg Arg Arg Gly 
465                 470                 475                 480 


Ala Asp Pro Glu Arg Arg His Pro Leu Pro Trp Arg His Gln Leu Gln 
                485                 490                 495     


Arg Val Arg Pro Leu Leu Ser Cys Tyr Pro Pro Gly His Ser Gln 
            500                 505                 510     

<210>  3569
<211>  3343
<212>  DNA
<213>  Homo sapiens

<400>  3569
aacctgtgga cggccgcggc cggcggacac acagcagcgg gggcccggcc gggggtcgcc     60

cgggggcccg gaagccgggg aagagcgagg aaaccaactt ggagagagga gtgacctggg    120

ggccgggggc ggagtcgtga gcgggggagg agagagccgg ccgccagcaa gagccgcgcg    180

gcggcccagg aagcgagagc gccgcccacc catccggggc aagagccgcg ccgcaggaga    240

ggcaggctgg accgggggct ccccgggccc gcgacccccg ccgtgacccc gcagccccca    300

gctcgccccc aagatgatga agaggcagct gcaccgcatg cggcagctgg cccagacggg    360

cagcttggga cggtagaaca gcggctggag ccggccaagc gggcagccca caacatccac    420

aagcggctgc aggcctgtct gcagggccag agcggggcag acatggacaa gcgggtgaag    480

aagcttcccc tcatggctct gtccaccacg atggctgaga gcttcaagga gctggaccct    540

gattccagca tggggaaggc cttggagatg agctgtgcca tccagaatca gctggcccgc    600

atcctggccg agtttgagat gaccctggag agggacgtcc tgcagccact cagcaggctg    660

agtgaggagg agctgccagc catcctcaaa cacaagaaaa gcctccagaa gctcgtgtcc    720

gactggaaca cactcaagag caggctcagt caggcaacca agaattcagg cagcagtcaa    780

ggcctaggag gcagcccggg tagtcacagc catacgacca tggccaacaa ggtggagacg    840

ctgaaggagg aggaggagga gctgaagagg aaagtggagc aatgcaggga cgagtacttg    900

gctgacctgt accactttgt taccaaggag gactcctatg ccaactactt cattcgtctc    960

ctggagattc aggccgatta ccatcgcagg tcactgagct cgctggacac agccctggct   1020

gagctgaggg agaaccacgg ccaagcagac cactcccctt cgatgacagc cacccacttc   1080

cccagggtgt atggggtgtc gctggcaacc cacctgcaag agctgggccg ggagattgcc   1140

ctgcccatcg aggcctgcgt catgatgctg ctttctgagg gcatgaagga agagggtctc   1200

ttccgtctgg ctgctggggc ctcggtgctg aagcgtctca agcagacaat ggcctcggac   1260

ccccacagcc tggaggagtt ctgctccgac ccgcacgctg tggcaggtgc cctcaagtcc   1320

tatctgcggg agctgccaga gcctctgatg accttcgacc tctatgatga ctggatgagg   1380

gcagccagcc tgaaggagcc aggggcccgg ctgcaggccc tccaagaggt gtgcagccgc   1440

ctaccccccg agaacctcag caacctcagg tacctgatga agttcctggc acggctggcc   1500

gaggagcagg aggtgaacaa gatgacaccc agcaacatcg ccatagtcct gggacccaac   1560

ttgctgtggc cacctgagaa agaaggggac caggcccagc tggatgcagc ctccgtgtct   1620

tccatccagg tggtgggcgt cgtcgaggcg ctgatccaga gcgcagacac cctcttccct   1680

ggagacatca acttcaacgt gtcaggcctc ttctcagctg ttaccctcca ggacacagtc   1740

agtgacaggc tggcctctga ggaacttccg tccactgccg tgcccacccc agccaccacc   1800

ccggctccgg ctccggctcc agctccagct ccggccccag ccttggcttc agcagctacc   1860

aaggaaagga cagagtctga ggtgcctccc agaccagcct cccccaaggt caccaggagt   1920

cccccggaga cagctgcccc agtggaggac atggctcgga ggagcaccgg gagcctggcc   1980

gctgcagtgg agacagcctc gggacgccag gccctggtgg tgggcaagcc cagcccctac   2040

atgttcgagt gcatcacgga gaacttcagc atcgaccccg cacgcacgct tatggtgggt   2100

gaccgcctgg agaccgacat cctctttggc caccgctgcg gcatgaccac tgtgctcacg   2160

ctcacaggag tctcccgcct agaagaggcc caggcctacc tagcggccgg ccagcacgac   2220

ctcgtgcccc attactatgt ggagagcatc gcagacttga cagaggggtt ggaggactga   2280

gcccactgca cctgcagcca caggcccacc cctccccact ccctgatccc gtaggtggag   2340

gcgatgggtc acgagccatg ttaagcacaa ccggctcctt ggtccagttc tgcaccgggg   2400

tggggctggg acccggggaa ggtttgaggg cccttgcaac cccctcccag cagtggctgg   2460

gcactctttg ctgccccaga agctggtccc ctatggattc atcttggcct gacccagcca   2520

ggtggcctta tttcttccct gtcacctccc ctccttgaaa tctgggccct ggtgcctgct   2580

gaagattccc tctatccctg agtacttagt cttctccccc ttccctgggg cttctagagc   2640

tctctctgcc cctcaggtcc tggcccttgg gtccttgtca accagaggtc tagggaacca   2700

caacccttat tgtcctgggt ggaccaatcc aaaggctaag tgatagtgac tcatcaatgt   2760

tgggtcctgt ggggtaccag tttaggttcc taagtaatag tgaccctttc acgtcctgga   2820

gcccgagtgg accaatcgga agcctaagtg acgatgaccc tcgcatgtcc taggtccctg   2880

ggtggaccca tcaggacccc aagtgatagt gacccagtgg tcttttagat cctcagtaga   2940

acagtccaga agcctgagag acagtggccc cttgataatc tgggtctcac gggaccagct   3000

aggggtccag gtttcagtca gtaaataaga gtggtccacg tcctaaagac acctctcctt   3060

tacaaagact tgtgatgctc tggggcttct gtggccaagc cccacccttt cctggtcatg   3120

gtacccgtac agcgttgatg gccacagctc gaaggggggc tttcgtgtcc ccctgtgcgg   3180

tcagtgtttt cagtaccacc tctctcccgt gcccacttgg ctatttactt atttatttat   3240

tgtgtgccag tgatggtggg tgggggctgg gccttccccg ccacctccac ccctgttgtg   3300

acctgtcctt ccgtacttaa taaagtgcgc gtgggagtgt tca                     3343


<210>  3570
<211>  605
<212>  PRT
<213>  Homo sapiens

<400>  3570


Met Asp Lys Arg Val Lys Lys Leu Pro Leu Met Ala Leu Ser Thr Thr 
1               5                   10                  15      


Met Ala Glu Ser Phe Lys Glu Leu Asp Pro Asp Ser Ser Met Gly Lys 
            20                  25                  30          


Ala Leu Glu Met Ser Cys Ala Ile Gln Asn Gln Leu Ala Arg Ile Leu 
        35                  40                  45              


Ala Glu Phe Glu Met Thr Leu Glu Arg Asp Val Leu Gln Pro Leu Ser 
    50                  55                  60                  


Arg Leu Ser Glu Glu Glu Leu Pro Ala Ile Leu Lys His Lys Lys Ser 
65                  70                  75                  80  


Leu Gln Lys Leu Val Ser Asp Trp Asn Thr Leu Lys Ser Arg Leu Ser 
                85                  90                  95      


Gln Ala Thr Lys Asn Ser Gly Ser Ser Gln Gly Leu Gly Gly Ser Pro 
            100                 105                 110         


Gly Ser His Ser His Thr Thr Met Ala Asn Lys Val Glu Thr Leu Lys 
        115                 120                 125             


Glu Glu Glu Glu Glu Leu Lys Arg Lys Val Glu Gln Cys Arg Asp Glu 
    130                 135                 140                 


Tyr Leu Ala Asp Leu Tyr His Phe Val Thr Lys Glu Asp Ser Tyr Ala 
145                 150                 155                 160 


Asn Tyr Phe Ile Arg Leu Leu Glu Ile Gln Ala Asp Tyr His Arg Arg 
                165                 170                 175     


Ser Leu Ser Ser Leu Asp Thr Ala Leu Ala Glu Leu Arg Glu Asn His 
            180                 185                 190         


Gly Gln Ala Asp His Ser Pro Ser Met Thr Ala Thr His Phe Pro Arg 
        195                 200                 205             


Val Tyr Gly Val Ser Leu Ala Thr His Leu Gln Glu Leu Gly Arg Glu 
    210                 215                 220                 


Ile Ala Leu Pro Ile Glu Ala Cys Val Met Met Leu Leu Ser Glu Gly 
225                 230                 235                 240 


Met Lys Glu Glu Gly Leu Phe Arg Leu Ala Ala Gly Ala Ser Val Leu 
                245                 250                 255     


Lys Arg Leu Lys Gln Thr Met Ala Ser Asp Pro His Ser Leu Glu Glu 
            260                 265                 270         


Phe Cys Ser Asp Pro His Ala Val Ala Gly Ala Leu Lys Ser Tyr Leu 
        275                 280                 285             


Arg Glu Leu Pro Glu Pro Leu Met Thr Phe Asp Leu Tyr Asp Asp Trp 
    290                 295                 300                 


Met Arg Ala Ala Ser Leu Lys Glu Pro Gly Ala Arg Leu Gln Ala Leu 
305                 310                 315                 320 


Gln Glu Val Cys Ser Arg Leu Pro Pro Glu Asn Leu Ser Asn Leu Arg 
                325                 330                 335     


Tyr Leu Met Lys Phe Leu Ala Arg Leu Ala Glu Glu Gln Glu Val Asn 
            340                 345                 350         


Lys Met Thr Pro Ser Asn Ile Ala Ile Val Leu Gly Pro Asn Leu Leu 
        355                 360                 365             


Trp Pro Pro Glu Lys Glu Gly Asp Gln Ala Gln Leu Asp Ala Ala Ser 
    370                 375                 380                 


Val Ser Ser Ile Gln Val Val Gly Val Val Glu Ala Leu Ile Gln Ser 
385                 390                 395                 400 


Ala Asp Thr Leu Phe Pro Gly Asp Ile Asn Phe Asn Val Ser Gly Leu 
                405                 410                 415     


Phe Ser Ala Val Thr Leu Gln Asp Thr Val Ser Asp Arg Leu Ala Ser 
            420                 425                 430         


Glu Glu Leu Pro Ser Thr Ala Val Pro Thr Pro Ala Thr Thr Pro Ala 
        435                 440                 445             


Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Leu Ala Ser Ala 
    450                 455                 460                 


Ala Thr Lys Glu Arg Thr Glu Ser Glu Val Pro Pro Arg Pro Ala Ser 
465                 470                 475                 480 


Pro Lys Val Thr Arg Ser Pro Pro Glu Thr Ala Ala Pro Val Glu Asp 
                485                 490                 495     


Met Ala Arg Arg Ser Thr Gly Ser Leu Ala Ala Ala Val Glu Thr Ala 
            500                 505                 510         


Ser Gly Arg Gln Ala Leu Val Val Gly Lys Pro Ser Pro Tyr Met Phe 
        515                 520                 525             


Glu Cys Ile Thr Glu Asn Phe Ser Ile Asp Pro Ala Arg Thr Leu Met 
    530                 535                 540                 


Val Gly Asp Arg Leu Glu Thr Asp Ile Leu Phe Gly His Arg Cys Gly 
545                 550                 555                 560 


Met Thr Thr Val Leu Thr Leu Thr Gly Val Ser Arg Leu Glu Glu Ala 
                565                 570                 575     


Gln Ala Tyr Leu Ala Ala Gly Gln His Asp Leu Val Pro His Tyr Tyr 
            580                 585                 590         


Val Glu Ser Ile Ala Asp Leu Thr Glu Gly Leu Glu Asp 
        595                 600                 605 

<210>  3571
<211>  2575
<212>  DNA
<213>  Homo sapiens

<400>  3571
cgcccaccca tccggggcaa gagccgcgcc gcaggagagg caggctggac cgggggctcc     60

ccgggcccgc gacccccgcc gtgaccccgc agcccccagc tcgcccccaa gatgatgaag    120

aggcagctgc accgcatgcg gcagctggcc cagacgggca gcttgggacg caccccggag    180

accgctgagt tcctgggtga ggacctgctg caggtagaac agcggctgga gccggccaag    240

cgggcagccc acaacatcca caagcggctg caggcctgtc tgcagggcca gagcggggca    300

gacatggaca agcgggtgaa gaagcttccc ctcatggctc tgtccaccac gatggctgag    360

agcttcaagg agctggaccc tgattccagc atggggaagg ccttggagat gagctgtgcc    420

atccagaatc agctggcccg catcctggcc gagtttgaga tgaccctgga gagggacgtc    480

ctgcagccac tcagcaggct gagtgaggag gagctgccag ccatcctcaa acacaagaaa    540

agcctccaga agctcgtgtc cgactggaac acactcaaga gcaggctcag tcaggcaacc    600

aagaattcag gcagcagtca aggcctagga ggcagcccgg gtagtcacag ccatacgacc    660

atggccaaca aggtggagac gctgaaggag gaggaggagg agctgaagag gaaagtggag    720

caatgcaggg acgagtactt ggctgacctg taccactttg ttaccaagga ggactcctat    780

gccaactact tcattcgtct cctggagatt caggccgatt accatcgcag gtcactgagc    840

tcgctggaca cagccctggc tgagctgagg gagaaccacg gccaagcaga ccactcccct    900

tcgatgacag ccacccactt ccccagggtg tatggggtgt cgctggcaac ccacctgcaa    960

gagctgggcc gggagattgc cctgcccatc gaggcctgcg tcatgatgct gctttctgag   1020

ggcatgaagg aagagggtct cttccgtctg gctgctgggg cctcggtgct gaagcgtctc   1080

aagcagacaa tggcctcgga cccccacagc ctggaggagt tctgctccga cccgcacgct   1140

gtggcaggtg ccctcaagtc ctatctgcgg gagctgccag agcctctgat gaccttcgac   1200

ctctatgatg actggatgag ggcagccagc ctgaaggagc caggggcccg gctgcaggcc   1260

ctccaagagg tgtgcagccg cctacccccc gagaacctca gcaacctcag gtacctgatg   1320

aagttcctgg cacggctggc cgaggagcag gaggtgaaca agatgacacc cagcaacatc   1380

gccatagtcc tgggacccaa cttgctgtgg ccacctgaga aagaagggga ccaggcccag   1440

ctggatgcag cctccgtgtc ttccatccag gtggtgggcg tcgtcgaggc gctgatccag   1500

agcgcagaca ccctcttccc tggagacatc aacttcaacg tgtcaggcct cttctcagct   1560

gttaccctcc aggacacagt cagtgacagg ctggcctctg aggaacttcc gtccactgcc   1620

gtgcccaccc cagccaccac cccggctccg gctccggctc cagctccagc tccggcccca   1680

gccttggctt cagcagctac caaggaaagg acagagtctg aggtgcctcc cagaccagcc   1740

tcccccaagg tcaccaggag tcccccggag acagctgccc cagtggagga catggctcgg   1800

aggaccaagc gcccggcgcc agcccggccc accatgccgc ccccccaggt ctccggctcc   1860

cgctcctccc ctccagcccc gcccttgccc cctggctctg gcagccctgg gaccccccaa   1920

gccctgcccc gacgtctggt tggcagcagc ctccgagccc ccacagtgcc acccccgtta   1980

ccccccacac cccctcagcc tgcccggcgc caaagccggc gttcaccagc ctcccccagc   2040

ccggcctccc caggtccagc ctcccccagc ccagtctctt tgagtaaccc tgcacaggtg   2100

gacctggggg ctgccacagc agagggagga gcccctgagg ctatcagtgg ggtccccact   2160

cccccagcta tcccccctca gccccgcccc aggagccttg cctcagagac caactgagtg   2220

gctggtttct ccctaagcag ccctcagcac cccctccctc cccacctggc cctcccagga   2280

cagctctcgc cccccacaaa ggggcatggg cctccagcct ttgcccacaa gtgcctcagt   2340

gcccactggg tcggccccca tggccaggag ggctcaggac aatcctctat ttcctgacct   2400

tttcctcgtc caccctgggc ttggggaccc ccccaccgga ctctccactc tccggcaggt   2460

cctaggggag ccaccggaag gaaggagagg tttgcctgct cctacgggac tgattcttct   2520

cttgccgaca tgttttttgt aaggctggta aataaattat tttggacaaa actgg        2575


<210>  3572
<211>  701
<212>  PRT
<213>  Homo sapiens

<400>  3572


Met Met Lys Arg Gln Leu His Arg Met Arg Gln Leu Ala Gln Thr Gly 
1               5                   10                  15      


Ser Leu Gly Arg Thr Pro Glu Thr Ala Glu Phe Leu Gly Glu Asp Leu 
            20                  25                  30          


Leu Gln Val Glu Gln Arg Leu Glu Pro Ala Lys Arg Ala Ala His Asn 
        35                  40                  45              


Ile His Lys Arg Leu Gln Ala Cys Leu Gln Gly Gln Ser Gly Ala Asp 
    50                  55                  60                  


Met Asp Lys Arg Val Lys Lys Leu Pro Leu Met Ala Leu Ser Thr Thr 
65                  70                  75                  80  


Met Ala Glu Ser Phe Lys Glu Leu Asp Pro Asp Ser Ser Met Gly Lys 
                85                  90                  95      


Ala Leu Glu Met Ser Cys Ala Ile Gln Asn Gln Leu Ala Arg Ile Leu 
            100                 105                 110         


Ala Glu Phe Glu Met Thr Leu Glu Arg Asp Val Leu Gln Pro Leu Ser 
        115                 120                 125             


Arg Leu Ser Glu Glu Glu Leu Pro Ala Ile Leu Lys His Lys Lys Ser 
    130                 135                 140                 


Leu Gln Lys Leu Val Ser Asp Trp Asn Thr Leu Lys Ser Arg Leu Ser 
145                 150                 155                 160 


Gln Ala Thr Lys Asn Ser Gly Ser Ser Gln Gly Leu Gly Gly Ser Pro 
                165                 170                 175     


Gly Ser His Ser His Thr Thr Met Ala Asn Lys Val Glu Thr Leu Lys 
            180                 185                 190         


Glu Glu Glu Glu Glu Leu Lys Arg Lys Val Glu Gln Cys Arg Asp Glu 
        195                 200                 205             


Tyr Leu Ala Asp Leu Tyr His Phe Val Thr Lys Glu Asp Ser Tyr Ala 
    210                 215                 220                 


Asn Tyr Phe Ile Arg Leu Leu Glu Ile Gln Ala Asp Tyr His Arg Arg 
225                 230                 235                 240 


Ser Leu Ser Ser Leu Asp Thr Ala Leu Ala Glu Leu Arg Glu Asn His 
                245                 250                 255     


Gly Gln Ala Asp His Ser Pro Ser Met Thr Ala Thr His Phe Pro Arg 
            260                 265                 270         


Val Tyr Gly Val Ser Leu Ala Thr His Leu Gln Glu Leu Gly Arg Glu 
        275                 280                 285             


Ile Ala Leu Pro Ile Glu Ala Cys Val Met Met Leu Leu Ser Glu Gly 
    290                 295                 300                 


Met Lys Glu Glu Gly Leu Phe Arg Leu Ala Ala Gly Ala Ser Val Leu 
305                 310                 315                 320 


Lys Arg Leu Lys Gln Thr Met Ala Ser Asp Pro His Ser Leu Glu Glu 
                325                 330                 335     


Phe Cys Ser Asp Pro His Ala Val Ala Gly Ala Leu Lys Ser Tyr Leu 
            340                 345                 350         


Arg Glu Leu Pro Glu Pro Leu Met Thr Phe Asp Leu Tyr Asp Asp Trp 
        355                 360                 365             


Met Arg Ala Ala Ser Leu Lys Glu Pro Gly Ala Arg Leu Gln Ala Leu 
    370                 375                 380                 


Gln Glu Val Cys Ser Arg Leu Pro Pro Glu Asn Leu Ser Asn Leu Arg 
385                 390                 395                 400 


Tyr Leu Met Lys Phe Leu Ala Arg Leu Ala Glu Glu Gln Glu Val Asn 
                405                 410                 415     


Lys Met Thr Pro Ser Asn Ile Ala Ile Val Leu Gly Pro Asn Leu Leu 
            420                 425                 430         


Trp Pro Pro Glu Lys Glu Gly Asp Gln Ala Gln Leu Asp Ala Ala Ser 
        435                 440                 445             


Val Ser Ser Ile Gln Val Val Gly Val Val Glu Ala Leu Ile Gln Ser 
    450                 455                 460                 


Ala Asp Thr Leu Phe Pro Gly Asp Ile Asn Phe Asn Val Ser Gly Leu 
465                 470                 475                 480 


Phe Ser Ala Val Thr Leu Gln Asp Thr Val Ser Asp Arg Leu Ala Ser 
                485                 490                 495     


Glu Glu Leu Pro Ser Thr Ala Val Pro Thr Pro Ala Thr Thr Pro Ala 
            500                 505                 510         


Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Leu Ala Ser Ala 
        515                 520                 525             


Ala Thr Lys Glu Arg Thr Glu Ser Glu Val Pro Pro Arg Pro Ala Ser 
    530                 535                 540                 


Pro Lys Val Thr Arg Ser Pro Pro Glu Thr Ala Ala Pro Val Glu Asp 
545                 550                 555                 560 


Met Ala Arg Arg Thr Lys Arg Pro Ala Pro Ala Arg Pro Thr Met Pro 
                565                 570                 575     


Pro Pro Gln Val Ser Gly Ser Arg Ser Ser Pro Pro Ala Pro Pro Leu 
            580                 585                 590         


Pro Pro Gly Ser Gly Ser Pro Gly Thr Pro Gln Ala Leu Pro Arg Arg 
        595                 600                 605             


Leu Val Gly Ser Ser Leu Arg Ala Pro Thr Val Pro Pro Pro Leu Pro 
    610                 615                 620                 


Pro Thr Pro Pro Gln Pro Ala Arg Arg Gln Ser Arg Arg Ser Pro Ala 
625                 630                 635                 640 


Ser Pro Ser Pro Ala Ser Pro Gly Pro Ala Ser Pro Ser Pro Val Ser 
                645                 650                 655     


Leu Ser Asn Pro Ala Gln Val Asp Leu Gly Ala Ala Thr Ala Glu Gly 
            660                 665                 670         


Gly Ala Pro Glu Ala Ile Ser Gly Val Pro Thr Pro Pro Ala Ile Pro 
        675                 680                 685             


Pro Gln Pro Arg Pro Arg Ser Leu Ala Ser Glu Thr Asn 
    690                 695                 700     

<210>  3573
<211>  2641
<212>  DNA
<213>  Homo sapiens

<400>  3573
cgcccaccca tccggggcaa gagccgcgcc gcaggagagg caggctggac cgggggctcc     60

ccgggcccgc gacccccgcc gtgaccccgc agcccccagc tcgcccccaa gatgatgaag    120

aggcagctgc accgcatgcg gcagctggcc cagacgggca gcttgggacg caccccggag    180

accgctgagt tcctgggtga ggacctgctg caggtagaac agcggctgga gccggccaag    240

cgggcagccc acaacatcca caagcggctg caggcctgtc tgcagggcca gagcggggca    300

gacatggaca agcgggtgaa gaagcttccc ctcatggctc tgtccaccac gatggctgag    360

agcttcaagg agctggaccc tgattccagc atggggaagg ccttggagat gagctgtgcc    420

atccagaatc agctggcccg catcctggcc gagtttgaga tgaccctgga gagggacgtc    480

ctgcagccac tcagcaggct gagtgaggag gagctgccag ccatcctcaa acacaagaaa    540

agcctccaga agctcgtgtc cgactggaac acactcaaga gcaggctcag tcaggcaacc    600

aagaattcag gcagcagtca aggcctagga ggcagcccgg gtagtcacag ccatacgacc    660

atggccaaca aggtggagac gctgaaggag gaggaggagg agctgaagag gaaagtggag    720

caatgcaggg acgagtactt ggctgacctg taccactttg ttaccaagga ggactcctat    780

gccaactact tcattcgtct cctggagatt caggccgatt accatcgcag gtcactgagc    840

tcgctggaca cagccctggc tgagctgagg gagaaccacg gccaagcaga ccactcccct    900

tcgatgacag ccacccactt ccccagggtg tatggggtgt cgctggcaac ccacctgcaa    960

gagctgggcc gggagattgc cctgcccatc gaggcctgcg tcatgatgct gctttctgag   1020

ggcatgaagg aagagggtct cttccgtctg gctgctgggg cctcggtgct gaagcgtctc   1080

aagcagacaa tggcctcgga cccccacagc ctggaggagt tctgctccga cccgcacgct   1140

gtggcaggtg ccctcaagtc ctatctgcgg gagctgccag agcctctgat gaccttcgac   1200

ctctatgatg actggatgag ggcagccagc ctgaaggagc caggggcccg gctgcaggcc   1260

ctccaagagg tgtgcagccg cctacccccc gagaacctca gcaacctcag gtacctgatg   1320

aagttcctgg cacggctggc cgaggagcag gaggtgaaca agatgacacc cagcaacatc   1380

gccatagtcc tgggacccaa cttgctgtgg ccacctgaga aagaagggga ccaggcccag   1440

ctggatgcag cctccgtgtc ttccatccag gtggtgggcg tcgtcgaggc gctgatccag   1500

agcgcagaca ccctcttccc tggagacatc aacttcaacg tgtcaggcct cttctcagct   1560

gttaccctcc aggacacagt cagtgacagg ctggcctctg aggaacttcc gtccactgcc   1620

gtgcccaccc cagccaccac cccggctccg gctccggctc cagctccagc tccggcccca   1680

gccttggctt cagcagctac caaggaaagg acagagtctg aggtgcctcc cagaccagcc   1740

tcccccaagg tcaccaggag tcccccggag acagctgccc cagtggagga catggctcgg   1800

aggaccaagc gcccggcgcc agcccggccc accatgccgc ccccccaggt ctccggctcc   1860

cgctcctccc ctccagcccc gcccttgccc cctggctctg gcagccctgg gaccccccaa   1920

gccctgcccc gacgtctggt tggcagcagc ctccgagccc ccacagtgcc acccccgtta   1980

ccccccacac cccctcagcc tgcccggcgc caaagccggc gttcaccagc ctcccccagc   2040

ccggcctccc caggtccagc ctcccccagc ccagtctctt tgagtaaccc tgcacaggtg   2100

gacctggggg ctgccacagc agagggagga gcccctgagg ctatcagtgg ggtccccact   2160

cccccagcta tcccccctca gccccgcccc aggagccttg cctcagagac caactgagtg   2220

gctggtttct ccctaagcag ccctcagcac cccctccctc cccacctggc cctcccagga   2280

cagctctcgc cccccacaaa ggggcatggg cctccagcct ttgcccacaa gtgcctcagt   2340

gcccactggg tcggccccca tggccaggag ggctcaggac aatcctctat ttcctgacct   2400

tttcctcgtc caccctgggc ttggggaccc ccccaccgga ctctccactc tccggcaggt   2460

cctaggggag ccaccggaag gaaggagagg tttgcctgct cctacgggac tgattcttct   2520

cttgccgaca tgttttttgt aaggctggta aataaattat tttggacaaa actggagcag   2580

ctgcccaaat gatagtttta ttttctgtcc ttgaaataaa gaagccaatt ttataaaggg   2640

g                                                                   2641


<210>  3574
<211>  701
<212>  PRT
<213>  Homo sapiens

<400>  3574


Met Met Lys Arg Gln Leu His Arg Met Arg Gln Leu Ala Gln Thr Gly 
1               5                   10                  15      


Ser Leu Gly Arg Thr Pro Glu Thr Ala Glu Phe Leu Gly Glu Asp Leu 
            20                  25                  30          


Leu Gln Val Glu Gln Arg Leu Glu Pro Ala Lys Arg Ala Ala His Asn 
        35                  40                  45              


Ile His Lys Arg Leu Gln Ala Cys Leu Gln Gly Gln Ser Gly Ala Asp 
    50                  55                  60                  


Met Asp Lys Arg Val Lys Lys Leu Pro Leu Met Ala Leu Ser Thr Thr 
65                  70                  75                  80  


Met Ala Glu Ser Phe Lys Glu Leu Asp Pro Asp Ser Ser Met Gly Lys 
                85                  90                  95      


Ala Leu Glu Met Ser Cys Ala Ile Gln Asn Gln Leu Ala Arg Ile Leu 
            100                 105                 110         


Ala Glu Phe Glu Met Thr Leu Glu Arg Asp Val Leu Gln Pro Leu Ser 
        115                 120                 125             


Arg Leu Ser Glu Glu Glu Leu Pro Ala Ile Leu Lys His Lys Lys Ser 
    130                 135                 140                 


Leu Gln Lys Leu Val Ser Asp Trp Asn Thr Leu Lys Ser Arg Leu Ser 
145                 150                 155                 160 


Gln Ala Thr Lys Asn Ser Gly Ser Ser Gln Gly Leu Gly Gly Ser Pro 
                165                 170                 175     


Gly Ser His Ser His Thr Thr Met Ala Asn Lys Val Glu Thr Leu Lys 
            180                 185                 190         


Glu Glu Glu Glu Glu Leu Lys Arg Lys Val Glu Gln Cys Arg Asp Glu 
        195                 200                 205             


Tyr Leu Ala Asp Leu Tyr His Phe Val Thr Lys Glu Asp Ser Tyr Ala 
    210                 215                 220                 


Asn Tyr Phe Ile Arg Leu Leu Glu Ile Gln Ala Asp Tyr His Arg Arg 
225                 230                 235                 240 


Ser Leu Ser Ser Leu Asp Thr Ala Leu Ala Glu Leu Arg Glu Asn His 
                245                 250                 255     


Gly Gln Ala Asp His Ser Pro Ser Met Thr Ala Thr His Phe Pro Arg 
            260                 265                 270         


Val Tyr Gly Val Ser Leu Ala Thr His Leu Gln Glu Leu Gly Arg Glu 
        275                 280                 285             


Ile Ala Leu Pro Ile Glu Ala Cys Val Met Met Leu Leu Ser Glu Gly 
    290                 295                 300                 


Met Lys Glu Glu Gly Leu Phe Arg Leu Ala Ala Gly Ala Ser Val Leu 
305                 310                 315                 320 


Lys Arg Leu Lys Gln Thr Met Ala Ser Asp Pro His Ser Leu Glu Glu 
                325                 330                 335     


Phe Cys Ser Asp Pro His Ala Val Ala Gly Ala Leu Lys Ser Tyr Leu 
            340                 345                 350         


Arg Glu Leu Pro Glu Pro Leu Met Thr Phe Asp Leu Tyr Asp Asp Trp 
        355                 360                 365             


Met Arg Ala Ala Ser Leu Lys Glu Pro Gly Ala Arg Leu Gln Ala Leu 
    370                 375                 380                 


Gln Glu Val Cys Ser Arg Leu Pro Pro Glu Asn Leu Ser Asn Leu Arg 
385                 390                 395                 400 


Tyr Leu Met Lys Phe Leu Ala Arg Leu Ala Glu Glu Gln Glu Val Asn 
                405                 410                 415     


Lys Met Thr Pro Ser Asn Ile Ala Ile Val Leu Gly Pro Asn Leu Leu 
            420                 425                 430         


Trp Pro Pro Glu Lys Glu Gly Asp Gln Ala Gln Leu Asp Ala Ala Ser 
        435                 440                 445             


Val Ser Ser Ile Gln Val Val Gly Val Val Glu Ala Leu Ile Gln Ser 
    450                 455                 460                 


Ala Asp Thr Leu Phe Pro Gly Asp Ile Asn Phe Asn Val Ser Gly Leu 
465                 470                 475                 480 


Phe Ser Ala Val Thr Leu Gln Asp Thr Val Ser Asp Arg Leu Ala Ser 
                485                 490                 495     


Glu Glu Leu Pro Ser Thr Ala Val Pro Thr Pro Ala Thr Thr Pro Ala 
            500                 505                 510         


Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Leu Ala Ser Ala 
        515                 520                 525             


Ala Thr Lys Glu Arg Thr Glu Ser Glu Val Pro Pro Arg Pro Ala Ser 
    530                 535                 540                 


Pro Lys Val Thr Arg Ser Pro Pro Glu Thr Ala Ala Pro Val Glu Asp 
545                 550                 555                 560 


Met Ala Arg Arg Thr Lys Arg Pro Ala Pro Ala Arg Pro Thr Met Pro 
                565                 570                 575     


Pro Pro Gln Val Ser Gly Ser Arg Ser Ser Pro Pro Ala Pro Pro Leu 
            580                 585                 590         


Pro Pro Gly Ser Gly Ser Pro Gly Thr Pro Gln Ala Leu Pro Arg Arg 
        595                 600                 605             


Leu Val Gly Ser Ser Leu Arg Ala Pro Thr Val Pro Pro Pro Leu Pro 
    610                 615                 620                 


Pro Thr Pro Pro Gln Pro Ala Arg Arg Gln Ser Arg Arg Ser Pro Ala 
625                 630                 635                 640 


Ser Pro Ser Pro Ala Ser Pro Gly Pro Ala Ser Pro Ser Pro Val Ser 
                645                 650                 655     


Leu Ser Asn Pro Ala Gln Val Asp Leu Gly Ala Ala Thr Ala Glu Gly 
            660                 665                 670         


Gly Ala Pro Glu Ala Ile Ser Gly Val Pro Thr Pro Pro Ala Ile Pro 
        675                 680                 685             


Pro Gln Pro Arg Pro Arg Ser Leu Ala Ser Glu Thr Asn 
    690                 695                 700     

<210>  3575
<211>  2613
<212>  DNA
<213>  Homo sapiens

<400>  3575
ctggactcag gtggaaatat ccccaggtct cccagctccc acccccagcc tctgagccgg     60

tggcacggag gccggaagtt tggggagcct ctcagagcct gtcttctctg ctcctcttcc    120

cccagcctca ggagttcccc attctctggg tccagggagg ggactgggtg tccagagacc    180

tggttctagt ctcacactgg cacagatgcc tacatagcct ggacagtcag accaccttgc    240

agtgggcctt ggcatccccc atgtgtcccc aggtgggggc caagggcctg tgcacccctg    300

cccacagctg tagtccagag tgctgtgtga ctgtgcctag gagtctgagc tcctgcactt    360

cccgttcttg gggccagcta atactcctca tcccggggtg ggctgaggat ttgggagtgg    420

gcagaaaaga ggcttctgtg tcccaaagct gggccccggg tgggtctctc agcctcccct    480

ttagtttcat ctgtccgccc tctctcagga cacagccctg ggtggaggag gaaaaaccca    540

tgtatcctat tcccaccccc atggaatgtg ctccgactgg gatgaagcaa ctgggccacc    600

cagggcaggc ctcagctggg agggacagtg gaagcactgg ggtccaggtg ccctgctgcg    660

gggaagggaa gtagggggcg ttctaaccca ggcaggctca gcagaagcac tctccccccc    720

ccccccacca ctccccgcag caccccggag accgctgagt tcctgggtga ggacctgctg    780

caggtagaac agcggctgga gccggccaag cgggcagccc acaacatcca caagcggctg    840

caggcctgtc tgcagggcca gagcggggca gacatggaca agcgggtgaa gaagcttccc    900

ctcatggctc tgtccaccac gatggctgag agcttcaagg agctggaccc tgattccagc    960

atggggtgag cacagacggg gcccagccct cacctgggga taccaagacg tgatctcagc   1020

tgggaggggg tccaggtggt gagggcatcc acatcagaag aatgaccagg ctggggacag   1080

ttcccaggaa ggccttggag atgagctgtg ccatccagaa tcagctggcc cgcatcctgg   1140

ccgagtttga gatgaccctg gagagggacg tcctgcagcc actcagcagg ctgagtgagg   1200

aggagctgcc agccatcctc aaacacaaga aaagcctcca gaagctcgtg tccgactgga   1260

acacactcaa gagcaggctc agtcaggcaa ccaagaattc aggcagcagt caaggcctag   1320

gaggcagccc gggtagtcac agccatacga ccatggccaa caaggtggag acgctgaagg   1380

aggaggagga ggagctgaag aggaaagtgg agcaatgcag ggacgagtac ttggctgacc   1440

tgtaccactt tgttaccaag gaggactcct atgccaacta cttcattcgt ctcctggaga   1500

ttcaggccga ttaccatcgc aggtcactga gctcgctgga cacagccctg gctgagctga   1560

gggagaacca cggccaagca gaccactccc cttcgatgac agccacccac ttccccaggg   1620

tgtatggggt gtcgctggca acccacctgc aagagctggg ccgggagatt gccctgccca   1680

tcgaggcctg cgtcatgatg ctgctttctg agggcatgaa ggaagagggt ctcttccgtc   1740

tggctgctgg ggcctcggtg ctgaagcgtc tcaagcagac aatggcctcg gacccccaca   1800

gcctggagga gttctgctcc gacccgcacg ctgtggcagg tgccctcaag tcctatctgc   1860

gggagctgcc agagcctctg atgaccttcg acctctatga tgactggatg agggcagcca   1920

gcctgaagga gccaggggcc cggctgcagg ccctccaaga ggtgtgcagc cgcctacccc   1980

ccgagaacct cagcaacctc aggtacctga tgaagttcct ggcacggctg gccgaggagc   2040

aggaggtgaa caagatgaca cccagcaaca tcgccatagt cctgggaccc aacttgctgt   2100

ggccacctga gaaagaaggg gaccaggccc agctggatgc agcctccgtg tcttccatcc   2160

aggtggtggg cgtcgtcgag gcgctgatcc agagcgcaga caccctcttc cctggagaca   2220

tcaacttcaa cgtgtcaggc ctcttctcag ctgttaccct ccaggacaca gtcagtgaca   2280

ggctggcctc tgaggaactt ccgtccactg ccgtgcccac cccagccacc accccggctc   2340

cggctccggc tccagctcca gctccggccc cagccttggc ttcagcagct accaaggaaa   2400

ggacagagtc tgaggtgcct cccagaccag cctcccccaa ggtcaccagg agtcccccgg   2460

agacagctgc cccagtggag gacatggctc ggaggagtcc taggggagcc accggaagga   2520

aggagaggtt tgcctgctcc tacgggactg attcttctct tgccgacatg ttttttgtaa   2580

ggctggtaaa taaattattt tggacaaaac tgg                                2613


<210>  3576
<211>  516
<212>  PRT
<213>  Homo sapiens

<400>  3576


Met Thr Arg Leu Gly Thr Val Pro Arg Lys Ala Leu Glu Met Ser Cys 
1               5                   10                  15      


Ala Ile Gln Asn Gln Leu Ala Arg Ile Leu Ala Glu Phe Glu Met Thr 
            20                  25                  30          


Leu Glu Arg Asp Val Leu Gln Pro Leu Ser Arg Leu Ser Glu Glu Glu 
        35                  40                  45              


Leu Pro Ala Ile Leu Lys His Lys Lys Ser Leu Gln Lys Leu Val Ser 
    50                  55                  60                  


Asp Trp Asn Thr Leu Lys Ser Arg Leu Ser Gln Ala Thr Lys Asn Ser 
65                  70                  75                  80  


Gly Ser Ser Gln Gly Leu Gly Gly Ser Pro Gly Ser His Ser His Thr 
                85                  90                  95      


Thr Met Ala Asn Lys Val Glu Thr Leu Lys Glu Glu Glu Glu Glu Leu 
            100                 105                 110         


Lys Arg Lys Val Glu Gln Cys Arg Asp Glu Tyr Leu Ala Asp Leu Tyr 
        115                 120                 125             


His Phe Val Thr Lys Glu Asp Ser Tyr Ala Asn Tyr Phe Ile Arg Leu 
    130                 135                 140                 


Leu Glu Ile Gln Ala Asp Tyr His Arg Arg Ser Leu Ser Ser Leu Asp 
145                 150                 155                 160 


Thr Ala Leu Ala Glu Leu Arg Glu Asn His Gly Gln Ala Asp His Ser 
                165                 170                 175     


Pro Ser Met Thr Ala Thr His Phe Pro Arg Val Tyr Gly Val Ser Leu 
            180                 185                 190         


Ala Thr His Leu Gln Glu Leu Gly Arg Glu Ile Ala Leu Pro Ile Glu 
        195                 200                 205             


Ala Cys Val Met Met Leu Leu Ser Glu Gly Met Lys Glu Glu Gly Leu 
    210                 215                 220                 


Phe Arg Leu Ala Ala Gly Ala Ser Val Leu Lys Arg Leu Lys Gln Thr 
225                 230                 235                 240 


Met Ala Ser Asp Pro His Ser Leu Glu Glu Phe Cys Ser Asp Pro His 
                245                 250                 255     


Ala Val Ala Gly Ala Leu Lys Ser Tyr Leu Arg Glu Leu Pro Glu Pro 
            260                 265                 270         


Leu Met Thr Phe Asp Leu Tyr Asp Asp Trp Met Arg Ala Ala Ser Leu 
        275                 280                 285             


Lys Glu Pro Gly Ala Arg Leu Gln Ala Leu Gln Glu Val Cys Ser Arg 
    290                 295                 300                 


Leu Pro Pro Glu Asn Leu Ser Asn Leu Arg Tyr Leu Met Lys Phe Leu 
305                 310                 315                 320 


Ala Arg Leu Ala Glu Glu Gln Glu Val Asn Lys Met Thr Pro Ser Asn 
                325                 330                 335     


Ile Ala Ile Val Leu Gly Pro Asn Leu Leu Trp Pro Pro Glu Lys Glu 
            340                 345                 350         


Gly Asp Gln Ala Gln Leu Asp Ala Ala Ser Val Ser Ser Ile Gln Val 
        355                 360                 365             


Val Gly Val Val Glu Ala Leu Ile Gln Ser Ala Asp Thr Leu Phe Pro 
    370                 375                 380                 


Gly Asp Ile Asn Phe Asn Val Ser Gly Leu Phe Ser Ala Val Thr Leu 
385                 390                 395                 400 


Gln Asp Thr Val Ser Asp Arg Leu Ala Ser Glu Glu Leu Pro Ser Thr 
                405                 410                 415     


Ala Val Pro Thr Pro Ala Thr Thr Pro Ala Pro Ala Pro Ala Pro Ala 
            420                 425                 430         


Pro Ala Pro Ala Pro Ala Leu Ala Ser Ala Ala Thr Lys Glu Arg Thr 
        435                 440                 445             


Glu Ser Glu Val Pro Pro Arg Pro Ala Ser Pro Lys Val Thr Arg Ser 
    450                 455                 460                 


Pro Pro Glu Thr Ala Ala Pro Val Glu Asp Met Ala Arg Arg Ser Pro 
465                 470                 475                 480 


Arg Gly Ala Thr Gly Arg Lys Glu Arg Phe Ala Cys Ser Tyr Gly Thr 
                485                 490                 495     


Asp Ser Ser Leu Ala Asp Met Phe Phe Val Arg Leu Val Asn Lys Leu 
            500                 505                 510         


Phe Trp Thr Lys 
        515     

<210>  3577
<211>  1518
<212>  DNA
<213>  Homo sapiens

<400>  3577
agcttaggcg agctggttgc tgggagaaaa acagatgtta aatgaactgc ctttgggtcg     60

aatctcattg ccccctgaat cgtggacgct ccagttcaga gcgaagtccc aagaaacctg    120

ctgaagccaa ggctggggcc ggagctggag ctggagccgg agccggagcc ggggtggtgg    180

ctggggtggg cacggcagtg gacggaagtt cctcagaggc cagcctgtca ctgactgtgt    240

cctggagggt aacagctgag aagaggcctg acacgttgaa gttgatgtct ggagacagaa    300

ggagcggaga cggctctcag agaccgcgcc aggctcctca ctccactggc cgggaccgtt    360

tccccttccc ctgaacccat ctggaccatg ttcagcttcc ccaccttcct cctggactta    420

tgttgtgatc tggacagcct ctaccaagca aatgcaatca gcacgtggga ggaaatcttg    480

ccatctgtgg ccaggtggcc acagcaagtt gggtcccagg actatggcga tgttgctggg    540

tgtcatcttg ttcacctcct gctcctcggc cagccgtgcc aggaacttca tcagctcctc    600

ctcctcctcc ttcagcgtct ccaccttgtt ggccatggtc gtatggctgt gactacccgg    660

gctgcctcct aggccttgac tgctgcctga attcttggtt gcctgactga gcctggagat    720

gatcccaagg gtcatctcaa actcggccag gatgcgggcc agctgattct ggatggcaca    780

gctcatctcc aaggccttcc tgtggacacg gcaccccatg ggtccaggcg cccgctgccc    840

tcacctccac tggaaacact tggtggggcc tctcctccct cacttccggc ccctcctaga    900

tatccttcat ctctgctaag ctgaacaccc tcccaggcct ggccaccctc actgacctgg    960

gaactgtccc cagcctggtc attcttctga tgtggatgcc ctcaccacct ggaccccctc   1020

ccagctgaga tcacgtcttg gtatccccag gtgagggctg ggccccgtct gtgctcaccc   1080

catgctggaa tcagggtcca gctccttgaa gctctcagcc atcgtggtgg acagagccat   1140

gaggggaagc ttcttctgca gggagggtgg ggccggcgat gagtgtccgt gcctccctcc   1200

accctgcctg agcaccaggc cagccccttg gggcagggga ggagggaacc caggagggcc   1260

acagtcccag atgagagtgg aaacaagatg acaaggcgtg gtgggggtga catttccctg   1320

agagcatgga tggagcccct ctccatctgg cgtgcccttt cctcttccca gaagccactt   1380

gactgggcgg tatatatggc tgacctagcc accgctgagt tcaaacgctc tatggctccc   1440

aatttccttg ccttggccac actgaattgt caactgattc caaaacatgg ccccacactc   1500

ccaccccatc tggagtta                                                 1518


<210>  3578
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  3578


Met Asn Cys Leu Trp Val Glu Ser His Cys Pro Leu Asn Arg Gly Arg 
1               5                   10                  15      


Ser Ser Ser Glu Arg Ser Pro Lys Lys Pro Ala Glu Ala Lys Ala Gly 
            20                  25                  30          


Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Val Val Ala Gly 
        35                  40                  45              


Val Gly Thr Ala Val Asp Gly Ser Ser Ser Glu Ala Ser Leu Ser Leu 
    50                  55                  60                  


Thr Val Ser Trp Arg Val Thr Ala Glu Lys Arg Pro Asp Thr Leu Lys 
65                  70                  75                  80  


Leu Met Ser Gly Asp Arg Arg Ser Gly Asp Gly Ser Gln Arg Pro Arg 
                85                  90                  95      


Gln Ala Pro His Ser Thr Gly Arg Asp Arg Phe Pro Phe Pro 
            100                 105                 110 

<210>  3579
<211>  560
<212>  DNA
<213>  Homo sapiens

<400>  3579
tggccacacc aggaggatgc tgtggggtct gctgagtaca gtgtgtgtac ttgtgcacgc     60

ctggtcccta ggagcacagg tggttagcgt atctgtgagg gtgtgcccgc gtgtgtcaca    120

gctggtgctg gggcaaccct aaagcctggg atcctgtaaa cagtcctgcg gcagccctgt    180

tctcccctct gtggagtggc tgtgatcacc aaattcccta agcagccctc agcaccccct    240

ccctccccac ctggccctcc caggacagct ctcgcccccc acaaaggggc atgggcctcc    300

agcctttgcc cacaagtgcc tcagtgccca ctgggtcggc ccccatggcc aggagggctc    360

aggacaatcc tctatttcct gaccttttcc tcgtccaccc tgggcttggg gaccccccca    420

ccggactctc cactctccgg caggtcctag gggagccacc ggaaggaagg agaggtttgc    480

ctgctcctac gggactgatt cttctcttgc cgacatgttt tttgtaaggc tggtaaataa    540

attattttgg acaaaactgg                                                560


<210>  3580
<211>  78
<212>  PRT
<213>  Homo sapiens

<400>  3580


Met Gly Leu Gln Pro Leu Pro Thr Ser Ala Ser Val Pro Thr Gly Ser 
1               5                   10                  15      


Ala Pro Met Ala Arg Arg Ala Gln Asp Asn Pro Leu Phe Pro Asp Leu 
            20                  25                  30          


Phe Leu Val His Pro Gly Leu Gly Asp Pro Pro Thr Gly Leu Ser Thr 
        35                  40                  45              


Leu Arg Gln Val Leu Gly Glu Pro Pro Glu Gly Arg Arg Gly Leu Pro 
    50                  55                  60                  


Ala Pro Thr Gly Leu Ile Leu Leu Leu Pro Thr Cys Phe Leu 
65                  70                  75              

<210>  3581
<211>  626
<212>  DNA
<213>  Homo sapiens

<400>  3581
tggccacacc aggaggatgc tgtggggtct gctgagtaca gtgtgtgtac ttgtgcacgc     60

ctggtcccta ggagcacagg tggttagcgt atctgtgagg gtgtgcccgc gtgtgtcaca    120

gctggtgctg gggcaaccct aaagcctggg atcctgtaaa cagtcctgcg gcagccctgt    180

tctcccctct gtggagtggc tgtgatcacc aaattcccta agcagccctc agcaccccct    240

ccctccccac ctggccctcc caggacagct ctcgcccccc acaaaggggc atgggcctcc    300

agcctttgcc cacaagtgcc tcagtgccca ctgggtcggc ccccatggcc aggagggctc    360

aggacaatcc tctatttcct gaccttttcc tcgtccaccc tgggcttggg gaccccccca    420

ccggactctc cactctccgg caggtcctag gggagccacc ggaaggaagg agaggtttgc    480

ctgctcctac gggactgatt cttctcttgc cgacatgttt tttgtaaggc tggtaaataa    540

attattttgg acaaaactgg agcagctgcc caaatgatag ttttattttc tgtccttgaa    600

ataaagaagc caattttata aagggg                                         626


<210>  3582
<211>  78
<212>  PRT
<213>  Homo sapiens

<400>  3582


Met Gly Leu Gln Pro Leu Pro Thr Ser Ala Ser Val Pro Thr Gly Ser 
1               5                   10                  15      


Ala Pro Met Ala Arg Arg Ala Gln Asp Asn Pro Leu Phe Pro Asp Leu 
            20                  25                  30          


Phe Leu Val His Pro Gly Leu Gly Asp Pro Pro Thr Gly Leu Ser Thr 
        35                  40                  45              


Leu Arg Gln Val Leu Gly Glu Pro Pro Glu Gly Arg Arg Gly Leu Pro 
    50                  55                  60                  


Ala Pro Thr Gly Leu Ile Leu Leu Leu Pro Thr Cys Phe Leu 
65                  70                  75              

<210>  3583
<211>  545
<212>  DNA
<213>  Homo sapiens

<400>  3583
cttaggcgag ctggttgctg ggagaaaaac agatgttaaa tgaactgcct ttgggtcgaa     60

tctcattgcc ccctgaatcg tggacgctcc agttcagagc gaagtcccaa gaaacctgct    120

gaagccaagg ctggggccgg agctggagct ggagccggag ccggagccgg ggtggtggct    180

ggggtgggca cggcagtgga cggaagttcc tcagaggcca gcctgtcact gactgtgtcc    240

tggagggtaa cagctgagaa gaggcctgac acgttgaagt tgatgtctgg agacagaagg    300

agcggagacg gctctcagag accgcgccag gctcctcact ccactggccg ggaccgtttc    360

cccttcccct gaacccatct ggaccatgtt cagcttcccc actcccgtgt gagcctcacc    420

accaccccac aaagcaggca gaccatcccc gttgtaaaaa tgagaaactg aggctcagac    480

ttcctcctgg acttatgttg tgatctggac agcctctacc aagcaaatgc aatcagcacg    540

tggga                                                                545


<210>  3584
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  3584


Met Asn Cys Leu Trp Val Glu Ser His Cys Pro Leu Asn Arg Gly Arg 
1               5                   10                  15      


Ser Ser Ser Glu Arg Ser Pro Lys Lys Pro Ala Glu Ala Lys Ala Gly 
            20                  25                  30          


Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Val Val Ala Gly 
        35                  40                  45              


Val Gly Thr Ala Val Asp Gly Ser Ser Ser Glu Ala Ser Leu Ser Leu 
    50                  55                  60                  


Thr Val Ser Trp Arg Val Thr Ala Glu Lys Arg Pro Asp Thr Leu Lys 
65                  70                  75                  80  


Leu Met Ser Gly Asp Arg Arg Ser Gly Asp Gly Ser Gln Arg Pro Arg 
                85                  90                  95      


Gln Ala Pro His Ser Thr Gly Arg Asp Arg Phe Pro Phe Pro 
            100                 105                 110 

<210>  3585
<211>  504
<212>  DNA
<213>  Homo sapiens

<400>  3585
acaaaaaaca tgtcggcaag agaagaatca gtcccgtagg agcaggcaaa cctctccttc     60

cttccggtgg ctcccctagg acctgccgga gagtggagag tccggtgggg gggtccccaa    120

gcccagggtg gacgaggaaa agctgctgaa gccaaggctg gggccggagc tggagctgga    180

gccggagccg gagccggggt ggtggctggg gtgggcacgg cagtggacgg aagttcctca    240

gaggccagcc tgtcactgac tgtgtcctgg agggtaacag ctgagaagag gcctgacacg    300

ttgaagttga tgtctggaga cagaaggagc ggagacggct ctcagagacc gcgccaggct    360

cctcactcca ctggccggga ccgtttcccc ttcccctgaa cccatctgga ccatgttcag    420

cttccccact cccgtgtgag cctcaccacc accccacaaa gcaggcagac catccccgtt    480

gtaaaaatga gaaactgagg ctca                                           504


<210>  3586
<211>  59
<212>  PRT
<213>  Homo sapiens

<400>  3586


Asp Leu Pro Glu Ser Gly Glu Ser Gly Gly Gly Val Pro Lys Pro Arg 
1               5                   10                  15      


Val Asp Glu Glu Lys Leu Leu Lys Pro Arg Leu Gly Pro Glu Leu Glu 
            20                  25                  30          


Leu Glu Pro Glu Pro Glu Pro Gly Trp Trp Leu Gly Trp Ala Arg Gln 
        35                  40                  45              


Trp Thr Glu Val Pro Gln Arg Pro Ala Cys His 
    50                  55                  

<210>  3587
<211>  2028
<212>  DNA
<213>  Homo sapiens

<400>  3587
tggaacgtgc cagggagagc gcgccgtgcc cgcggagaga gcgcggcgcg ggaggccggc     60

ggccggccgg ctgcatggcg cgctgcgaga ggctgcgcgg agcggccctg cgcgacgtgc    120

tgggccgggc gcagggggtc ctgttcgact gtgacggggt gctgtggaac ggcgagcgcg    180

ccgtgccggg cgccccggag ctgctggagc ggctggcgcg ggccggcaag gcggctctgt    240

ttgtgagcaa caacagccgg cgcgcgcggc ccgagctggc cctgcgcttc gcgcgcctcg    300

gcttcggggg gctgcgcgcc gagcagctct tcagctccgc gctgtgcgcc gcgcgcctgc    360

tgcgccagcg cctgcccggg cctccggacg cgccgggcgc cgtgttcgtg ctgggcggcg    420

aggggctgcg cgccgagctg cgcgccgcgg ggctgcgcct ggccggggac ccgagcgcgg    480

gggacggcgc ggccccgcgc gtgcgcgccg tgcttgtggg ctacgacgag cacttctcct    540

tcgccaagct gagggaggcg tgcgcgcacc tgcgcgaccc cgagtgccta ctcgtggcca    600

ccgaccgtga cccatggcac ccgctgagcg acggcagccg gacccctggc accgggagcc    660

tggccgctgc agtggagaca gcctcgggac gccaggccct ggtggtgggc aagcccagcc    720

cctacatgtt cgagtgcatc acggagaact tcagcatcga ccccgcacgc acgcttatgg    780

tgggtgaccg cctggagacc gacatcctct ttggccaccg ctgcggcatg accactgtgc    840

tcacgctcac aggagtctcc cgcctagaag aggcccaggc ctacctagcg gccggccagc    900

acgacctcgt gccccattac tatgtggaga gcatcgcaga cttgacagag gggttggagg    960

actgagccca ctgcacctgc agccacaggc ccacccctcc ccactccctg atcccgtagg   1020

tggaggcgat gggtcacgag ccatgttaag cacaaccggc tccttggtcc agttctgcac   1080

cggggtgggg ctgggacccg gggaaggttt gagggccctt gcaaccccct cccagcagtg   1140

gctgggcact ctttgctgcc ccagaagctg gtcccctatg gattcatctt ggcctgaccc   1200

agccaggtgg ccttatttct tccctgtcac ctcccctcct tgaaatctgg gccctggtgc   1260

ctgctgaaga ttccctctat ccctgagtac ttagtcttct cccccttccc tggggcttct   1320

agagctctct ctgcccctca ggtcctggcc cttgggtcct tgtcaaccag aggtctaggg   1380

aaccacaacc cttattgtcc tgggtggacc aatccaaagg ctaagtgata gtgactcatc   1440

aatgttgggt cctgtggggt accagtttag gttcctaagt aatagtgacc ctttcacgtc   1500

ctggagcccg agtggaccaa tcggaagcct aagtgacgat gaccctcgca tgtcctaggt   1560

ccctgggtgg acccatcagg accccaagtg atagtgaccc agtggtcttt tagatcctca   1620

gtagaacagt ccagaagcct gagagacagt ggccccttga taatctgggt ctcacgggac   1680

cagctagggg tccaggtttc agtcagtaaa taagagtggt ccacgtccta aagacacctc   1740

tcctttacaa agacttgtga tgctctgggg cttctgtggc caagccccac cctttcctgg   1800

tcatggtacc cgtacagcgt tgatggccac agctcgaagg ggggctttcg tgtccccctg   1860

tgcggtcagt gttttcagta ccacctctct cccgtgccca cttggctatt tacttattta   1920

tttattgtgt gccagtgatg gtgggtgggg gctgggcctt ccccgccacc tccacccctg   1980

ttgtgacctg tccttccgta cttaataaag tgcgcgtggg agtgttca                2028


<210>  3588
<211>  296
<212>  PRT
<213>  Homo sapiens

<400>  3588


Met Ala Arg Cys Glu Arg Leu Arg Gly Ala Ala Leu Arg Asp Val Leu 
1               5                   10                  15      


Gly Arg Ala Gln Gly Val Leu Phe Asp Cys Asp Gly Val Leu Trp Asn 
            20                  25                  30          


Gly Glu Arg Ala Val Pro Gly Ala Pro Glu Leu Leu Glu Arg Leu Ala 
        35                  40                  45              


Arg Ala Gly Lys Ala Ala Leu Phe Val Ser Asn Asn Ser Arg Arg Ala 
    50                  55                  60                  


Arg Pro Glu Leu Ala Leu Arg Phe Ala Arg Leu Gly Phe Gly Gly Leu 
65                  70                  75                  80  


Arg Ala Glu Gln Leu Phe Ser Ser Ala Leu Cys Ala Ala Arg Leu Leu 
                85                  90                  95      


Arg Gln Arg Leu Pro Gly Pro Pro Asp Ala Pro Gly Ala Val Phe Val 
            100                 105                 110         


Leu Gly Gly Glu Gly Leu Arg Ala Glu Leu Arg Ala Ala Gly Leu Arg 
        115                 120                 125             


Leu Ala Gly Asp Pro Ser Ala Gly Asp Gly Ala Ala Pro Arg Val Arg 
    130                 135                 140                 


Ala Val Leu Val Gly Tyr Asp Glu His Phe Ser Phe Ala Lys Leu Arg 
145                 150                 155                 160 


Glu Ala Cys Ala His Leu Arg Asp Pro Glu Cys Leu Leu Val Ala Thr 
                165                 170                 175     


Asp Arg Asp Pro Trp His Pro Leu Ser Asp Gly Ser Arg Thr Pro Gly 
            180                 185                 190         


Thr Gly Ser Leu Ala Ala Ala Val Glu Thr Ala Ser Gly Arg Gln Ala 
        195                 200                 205             


Leu Val Val Gly Lys Pro Ser Pro Tyr Met Phe Glu Cys Ile Thr Glu 
    210                 215                 220                 


Asn Phe Ser Ile Asp Pro Ala Arg Thr Leu Met Val Gly Asp Arg Leu 
225                 230                 235                 240 


Glu Thr Asp Ile Leu Phe Gly His Arg Cys Gly Met Thr Thr Val Leu 
                245                 250                 255     


Thr Leu Thr Gly Val Ser Arg Leu Glu Glu Ala Gln Ala Tyr Leu Ala 
            260                 265                 270         


Ala Gly Gln His Asp Leu Val Pro His Tyr Tyr Val Glu Ser Ile Ala 
        275                 280                 285             


Asp Leu Thr Glu Gly Leu Glu Asp 
    290                 295     

<210>  3589
<211>  1956
<212>  DNA
<213>  Homo sapiens

<400>  3589
tggaacgtgc cagggagagc gcgccgtgcc cgcggagaga gcgcggcgcg ggaggccggc     60

ggccggccgg ctgcatggcg cgctgcgaga ggctgcgcgg agcggccctg cgcgacgtgc    120

tgggccgggc gcagggggtc ctgttcgact gtgacggggt gctgtggaac ggcgagcgcg    180

ccgtgccggg cgccccggag ctgctggagc ggctggcgcg ggccggcaag gcggctctgt    240

ttgtgagcaa caacagccgg cgcgcgcggc ccgagctggc cctgcgcttc gcgcgcctcg    300

gcttcggggg gctgcgcgcc gagcagctct tcagctccgc gctgtgcgcc gcgcgcctgc    360

tgcgccagcg cctgcccggg cctccggacg cgccgggcgc cgtgttcgtg ctgggcggcg    420

aggggctgcg cgccgagctg cttgtgggct acgacgagca cttctccttc gccaagctga    480

gggaggcgtg cgcgcacctg cgcgaccccg agtgcctact cgtggccacc gaccgtgacc    540

catggcaccc gctgagcgac ggcagccgga cccctggcac cgggagcctg gccgctgcag    600

tggagacagc ctcgggacgc caggccctgg tggtgggcaa gcccagcccc tacatgttcg    660

agtgcatcac ggagaacttc agcatcgacc ccgcacgcac gcttatggtg ggtgaccgcc    720

tggagaccga catcctcttt ggccaccgct gcggcatgac cactgtgctc acgctcacag    780

gagtctcccg cctagaagag gcccaggcct acctagcggc cggccagcac gacctcgtgc    840

cccattacta tgtggagagc atcgcagact tgacagaggg gttggaggac tgagcccact    900

gcacctgcag ccacaggccc acccctcccc actccctgat cccgtaggtg gaggcgatgg    960

gtcacgagcc atgttaagca caaccggctc cttggtccag ttctgcaccg gggtggggct   1020

gggacccggg gaaggtttga gggcccttgc aaccccctcc cagcagtggc tgggcactct   1080

ttgctgcccc agaagctggt cccctatgga ttcatcttgg cctgacccag ccaggtggcc   1140

ttatttcttc cctgtcacct cccctccttg aaatctgggc cctggtgcct gctgaagatt   1200

ccctctatcc ctgagtactt agtcttctcc cccttccctg gggcttctag agctctctct   1260

gcccctcagg tcctggccct tgggtccttg tcaaccagag gtctagggaa ccacaaccct   1320

tattgtcctg ggtggaccaa tccaaaggct aagtgatagt gactcatcaa tgttgggtcc   1380

tgtggggtac cagtttaggt tcctaagtaa tagtgaccct ttcacgtcct ggagcccgag   1440

tggaccaatc ggaagcctaa gtgacgatga ccctcgcatg tcctaggtcc ctgggtggac   1500

ccatcaggac cccaagtgat agtgacccag tggtctttta gatcctcagt agaacagtcc   1560

agaagcctga gagacagtgg ccccttgata atctgggtct cacgggacca gctaggggtc   1620

caggtttcag tcagtaaata agagtggtcc acgtcctaaa gacacctctc ctttacaaag   1680

acttgtgatg ctctggggct tctgtggcca agccccaccc tttcctggtc atggtacccg   1740

tacagcgttg atggccacag ctcgaagggg ggctttcgtg tccccctgtg cggtcagtgt   1800

tttcagtacc acctctctcc cgtgcccact tggctattta cttatttatt tattgtgtgc   1860

cagtgatggt gggtgggggc tgggccttcc ccgccacctc cacccctgtt gtgacctgtc   1920

cttccgtact taataaagtg cgcgtgggag tgttca                             1956


<210>  3590
<211>  272
<212>  PRT
<213>  Homo sapiens

<400>  3590


Met Ala Arg Cys Glu Arg Leu Arg Gly Ala Ala Leu Arg Asp Val Leu 
1               5                   10                  15      


Gly Arg Ala Gln Gly Val Leu Phe Asp Cys Asp Gly Val Leu Trp Asn 
            20                  25                  30          


Gly Glu Arg Ala Val Pro Gly Ala Pro Glu Leu Leu Glu Arg Leu Ala 
        35                  40                  45              


Arg Ala Gly Lys Ala Ala Leu Phe Val Ser Asn Asn Ser Arg Arg Ala 
    50                  55                  60                  


Arg Pro Glu Leu Ala Leu Arg Phe Ala Arg Leu Gly Phe Gly Gly Leu 
65                  70                  75                  80  


Arg Ala Glu Gln Leu Phe Ser Ser Ala Leu Cys Ala Ala Arg Leu Leu 
                85                  90                  95      


Arg Gln Arg Leu Pro Gly Pro Pro Asp Ala Pro Gly Ala Val Phe Val 
            100                 105                 110         


Leu Gly Gly Glu Gly Leu Arg Ala Glu Leu Leu Val Gly Tyr Asp Glu 
        115                 120                 125             


His Phe Ser Phe Ala Lys Leu Arg Glu Ala Cys Ala His Leu Arg Asp 
    130                 135                 140                 


Pro Glu Cys Leu Leu Val Ala Thr Asp Arg Asp Pro Trp His Pro Leu 
145                 150                 155                 160 


Ser Asp Gly Ser Arg Thr Pro Gly Thr Gly Ser Leu Ala Ala Ala Val 
                165                 170                 175     


Glu Thr Ala Ser Gly Arg Gln Ala Leu Val Val Gly Lys Pro Ser Pro 
            180                 185                 190         


Tyr Met Phe Glu Cys Ile Thr Glu Asn Phe Ser Ile Asp Pro Ala Arg 
        195                 200                 205             


Thr Leu Met Val Gly Asp Arg Leu Glu Thr Asp Ile Leu Phe Gly His 
    210                 215                 220                 


Arg Cys Gly Met Thr Thr Val Leu Thr Leu Thr Gly Val Ser Arg Leu 
225                 230                 235                 240 


Glu Glu Ala Gln Ala Tyr Leu Ala Ala Gly Gln His Asp Leu Val Pro 
                245                 250                 255     


His Tyr Tyr Val Glu Ser Ile Ala Asp Leu Thr Glu Gly Leu Glu Asp 
            260                 265                 270         

<210>  3591
<211>  1573
<212>  DNA
<213>  Homo sapiens

<400>  3591
atcactttcc cgggggacgc ggactgggtc agaggtgcga acatttctgt gccccgctgt     60

gttccaaagg ggctgtgcca gtttctaacg ccagccgcgt gaattcctgc agcagtaacc    120

acaactgcta tttgttaagt gctgttccat ttacaaagca cttgcccctg tgttgcccag    180

cgcccgtttg gaggcaccgg gagcctggcc gctgcagtgg agacagcctc gggacgccag    240

gccctggtgg tgggcaagcc cagcccctac atgttcgagt gcatcacgga gaacttcagc    300

atcgaccccg cacgcacgct tatggtgggt gaccgcctgg agaccgacat cctctttggc    360

caccgctgcg gcatgaccac tgtgctcacg ctcacaggag tctcccgcct agaagaggcc    420

caggcctacc tagcggccgg ccagcacgac ctcgtgcccc attactatgt ggagagcatc    480

gcagacttga cagaggggtt ggaggactga gcccactgca cctgcagcca caggcccacc    540

cctccccact ccctgatccc gtaggtggag gcgatgggtc acgagccatg ttaagcacaa    600

ccggctcctt ggtccagttc tgcaccgggg tggggctggg acccggggaa ggtttgaggg    660

cccttgcaac cccctcccag cagtggctgg gcactctttg ctgccccaga agctggtccc    720

ctatggattc atcttggcct gacccagcca ggtggcctta tttcttccct gtcacctccc    780

ctccttgaaa tctgggccct ggtgcctgct gaagattccc tctatccctg agtacttagt    840

cttctccccc ttccctgggg cttctagagc tctctctgcc cctcaggtcc tggcccttgg    900

gtccttgtca accagaggtc tagggaacca caacccttat tgtcctgggt ggaccaatcc    960

aaaggctaag tgatagtgac tcatcaatgt tgggtcctgt ggggtaccag tttaggttcc   1020

taagtaatag tgaccctttc acgtcctgga gcccgagtgg accaatcgga agcctaagtg   1080

acgatgaccc tcgcatgtcc taggtccctg ggtggaccca tcaggacccc aagtgatagt   1140

gacccagtgg tcttttagat cctcagtaga acagtccaga agcctgagag acagtggccc   1200

cttgataatc tgggtctcac gggaccagct aggggtccag gtttcagtca gtaaataaga   1260

gtggtccacg tcctaaagac acctctcctt tacaaagact tgtgatgctc tggggcttct   1320

gtggccaagc cccacccttt cctggtcatg gtacccgtac agcgttgatg gccacagctc   1380

gaaggggggc tttcgtgtcc ccctgtgcgg tcagtgtttt cagtaccacc tctctcccgt   1440

gcccacttgg ctatttactt atttatttat tgtgtgccag tgatggtggg tgggggctgg   1500

gccttccccg ccacctccac ccctgttgtg acctgtcctt ccgtacttaa taaagtgcgc   1560

gtgggagtgt tca                                                      1573


<210>  3592
<211>  81
<212>  PRT
<213>  Homo sapiens

<400>  3592


Met Leu Trp Gly Phe Cys Gly Gln Ala Pro Pro Phe Pro Gly His Gly 
1               5                   10                  15      


Thr Arg Thr Ala Leu Met Ala Thr Ala Arg Arg Gly Ala Phe Val Ser 
            20                  25                  30          


Pro Cys Ala Val Ser Val Phe Ser Thr Thr Ser Leu Pro Cys Pro Leu 
        35                  40                  45              


Gly Tyr Leu Leu Ile Tyr Leu Leu Cys Ala Ser Asp Gly Gly Trp Gly 
    50                  55                  60                  


Leu Gly Leu Pro Arg His Leu His Pro Cys Cys Asp Leu Ser Phe Arg 
65                  70                  75                  80  


Thr 
    

<210>  3593
<211>  562
<212>  DNA
<213>  Homo sapiens

<400>  3593
agttaaaagg gtgggagcgt ccgggggccc atctctctcg ggtggagtct tctgacagct     60

ggtgcgcctg cccgggaaca tcctcctgga ctcaatcatg gcttgtggtc tggtcgccag    120

caacctgaat ctcaaacctg gagagtgcct tcgagtgcga ggcgaggtgg ctcctgacgc    180

taagagcttc gtgctgaacc tgggcaaaga cagcaacaac ctgtgcctgc acttcaaccc    240

tcgcttcaac gcccacggcg acgccaacac catcgtgtgc aacagcaagg acggcggggc    300

ctgggggacc gagcagcggg aggctgtctt tcccttccag cctggaagtg ttgcagaggt    360

gtgcatcacc ttcgaccagg ccaacctgac cgtcaagctg ccagatggat acgaattcaa    420

gttccccaac cgcctcaacc tggaggccat caactacatg gcagctgacg gtgacttcaa    480

gatcaaatgt gtggcctttg actgaaatca gccagcccat ggcccccaat aaaggcagct    540

gcctctgctc cctctgaacc ag                                             562


<210>  3594
<211>  135
<212>  PRT
<213>  Homo sapiens

<400>  3594


Met Ala Cys Gly Leu Val Ala Ser Asn Leu Asn Leu Lys Pro Gly Glu 
1               5                   10                  15      


Cys Leu Arg Val Arg Gly Glu Val Ala Pro Asp Ala Lys Ser Phe Val 
            20                  25                  30          


Leu Asn Leu Gly Lys Asp Ser Asn Asn Leu Cys Leu His Phe Asn Pro 
        35                  40                  45              


Arg Phe Asn Ala His Gly Asp Ala Asn Thr Ile Val Cys Asn Ser Lys 
    50                  55                  60                  


Asp Gly Gly Ala Trp Gly Thr Glu Gln Arg Glu Ala Val Phe Pro Phe 
65                  70                  75                  80  


Gln Pro Gly Ser Val Ala Glu Val Cys Ile Thr Phe Asp Gln Ala Asn 
                85                  90                  95      


Leu Thr Val Lys Leu Pro Asp Gly Tyr Glu Phe Lys Phe Pro Asn Arg 
            100                 105                 110         


Leu Asn Leu Glu Ala Ile Asn Tyr Met Ala Ala Asp Gly Asp Phe Lys 
        115                 120                 125             


Ile Lys Cys Val Ala Phe Asp 
    130                 135 

<210>  3595
<211>  743
<212>  DNA
<213>  Homo sapiens

<400>  3595
agttaaaagg gtgggagcgt ccgggggccc atctctctcg ggtggagtct tctgacagct     60

ggtgcgcctg cccgggaaca tcctcctgga ctcaatcatg gcttgtggtc tggtcgccag    120

caacctgaat ctcaaacctg gagagtgcct tcgagtgcga ggcgaggtgg ctcctgacgc    180

taagagcttc gtgctgaacc tgggcaaaga cagcaacaac ctgtgcctgc acttcaaccc    240

tcgcttcaac gcccacggcg acgccaacac catcgtgtgc aacagcaagg acggcggggc    300

ctgggggacc gagcagcggg aggctgtctt tcccttccag cctggaagtg ttgcagaggt    360

gtgcatcacc ttcgaccagg ccaacctgac cgtcaagctg ccagatggat acgaattcaa    420

gttccccaac cgcctcaacc tggaggccat caactacatg gcagctgacg gtgacttcaa    480

gatcaaatgt gtggcctttg actgaaatca gccagcccat ggcccccaat aaaggcagct    540

gcctctgctc cctctgaacc agcctcgtgt gtgtgcttgt gcgtgtgtgt gtatgtgtgt    600

gcatgtgttt gtgtgtgtga gaggggtccc ccacctccag gcctgccccc ttccttcact    660

tccattcgct ttgtccacgg gtacctcctc agttccaatg acgtcttccg ctgggtcccc    720

cagacaaagc acacagagtt tgg                                            743


<210>  3596
<211>  135
<212>  PRT
<213>  Homo sapiens

<400>  3596


Met Ala Cys Gly Leu Val Ala Ser Asn Leu Asn Leu Lys Pro Gly Glu 
1               5                   10                  15      


Cys Leu Arg Val Arg Gly Glu Val Ala Pro Asp Ala Lys Ser Phe Val 
            20                  25                  30          


Leu Asn Leu Gly Lys Asp Ser Asn Asn Leu Cys Leu His Phe Asn Pro 
        35                  40                  45              


Arg Phe Asn Ala His Gly Asp Ala Asn Thr Ile Val Cys Asn Ser Lys 
    50                  55                  60                  


Asp Gly Gly Ala Trp Gly Thr Glu Gln Arg Glu Ala Val Phe Pro Phe 
65                  70                  75                  80  


Gln Pro Gly Ser Val Ala Glu Val Cys Ile Thr Phe Asp Gln Ala Asn 
                85                  90                  95      


Leu Thr Val Lys Leu Pro Asp Gly Tyr Glu Phe Lys Phe Pro Asn Arg 
            100                 105                 110         


Leu Asn Leu Glu Ala Ile Asn Tyr Met Ala Ala Asp Gly Asp Phe Lys 
        115                 120                 125             


Ile Lys Cys Val Ala Phe Asp 
    130                 135 

<210>  3597
<211>  447
<212>  DNA
<213>  Homo sapiens

<400>  3597
ccgggggccc atctctctcg ggtggagtct tctgacagct ggtgcgcctg cccgggaaca     60

tcctcctgga ctcaatcatg gcttgtggtc tggtcgccag caacctgaat ctcaaacctg    120

gagagtgcct tcgagtgcga ggcgaggtgg ctcctgacgc taagagcttc gtgctgaacc    180

tgggcaaaga cagcaacaac ctgtgcctgc acttcaaccc tcgcttcaac gcccacggcg    240

acgccaacac catcgtgtgc aacagcaagg acggcggggc ctgggggacc gagcagcggg    300

aggctgtctt tcccttccag cctggaagtg ttgcagaggt gtgcatcacc ttcgaccagg    360

ccaacctctg acggtgactt caagatcaaa tgtgtggcct ttgactgaaa tcagccagcc    420

catggccccc aataaaggca gctgcct                                        447


<210>  3598
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  3598


Met Ala Cys Gly Leu Val Ala Ser Asn Leu Asn Leu Lys Pro Gly Glu 
1               5                   10                  15      


Cys Leu Arg Val Arg Gly Glu Val Ala Pro Asp Ala Lys Ser Phe Val 
            20                  25                  30          


Leu Asn Leu Gly Lys Asp Ser Asn Asn Leu Cys Leu His Phe Asn Pro 
        35                  40                  45              


Arg Phe Asn Ala His Gly Asp Ala Asn Thr Ile Val Cys Asn Ser Lys 
    50                  55                  60                  


Asp Gly Gly Ala Trp Gly Thr Glu Gln Arg Glu Ala Val Phe Pro Phe 
65                  70                  75                  80  


Gln Pro Gly Ser Val Ala Glu Val Cys Ile Thr Phe Asp Gln Ala Asn 
                85                  90                  95      


Leu 
    

<210>  3599
<211>  359
<212>  DNA
<213>  Homo sapiens

<400>  3599
atctctctcg ggtggagtct tctgacagct ggtgcgcctg cccgggaaca tcctcctgga     60

ctcaatcatg gcttgtggtc tggtcgccag caacctgaat ctcaaacctg gagagtgcct    120

tcgagtgcga ggcgaggtgg ctcctgacgc taagaggtgt gcatcacctt cgaccaggcc    180

aacctgaccg tcaagctgcc agatggatac gaattcaagt tccccaaccg cctcaacctg    240

gaggccatca actacatggc agctgacggt gacttcaaga tcaaatgtgt ggcctttgac    300

tgaaatcagc cagcccatgg cccccaataa aggcagctgc ctctgctccc tctgaacca     359


<210>  3600
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  3600


Met Ala Cys Gly Leu Val Ala Ser Asn Leu Asn Leu Lys Pro Gly Glu 
1               5                   10                  15      


Cys Leu Arg Val Arg Gly Glu Val Ala Pro Asp Ala Lys Arg Cys Ala 
            20                  25                  30          


Ser Pro Ser Thr Arg Pro Thr 
        35                  

<210>  3601
<211>  463
<212>  DNA
<213>  Homo sapiens

<400>  3601
ctctctcggg tggagtcttc tgacagctgg tgcgcctgcc cgggaacatc ctcctggact     60

caatcatggc ttgtggtctg gtcgccagca acctgaatcc tgggcaaaga cagcaacaac    120

ctgtgcctgc acttcaaccc tcgcttcaac gcccacggcg acgccaacac catcgtgtgc    180

aacagcaagg acggcggggc ctgggggacc gagcagcggg aggctgtctt tcccttccag    240

cctggaagtg ttgcagaggt gtgcatcacc ttcgaccagg ccaacctgac cgtcaagctg    300

ccagatggat acgaattcaa gttccccaac cgcctcaacc tggaggccat caactacatg    360

gcagctgacg gtgacttcaa gatcaaatgt gtggcctttg actgaaatca gccagcccat    420

ggcccccaat aaaggcagct gcctctgctc cctctgaacc agc                      463


<210>  3602
<211>  100
<212>  PRT
<213>  Homo sapiens

<400>  3602


Met Ala Cys Gly Leu Val Ala Ser Asn Leu Asn Pro Gly Gln Arg Gln 
1               5                   10                  15      


Gln Gln Pro Val Pro Ala Leu Gln Pro Ser Leu Gln Arg Pro Arg Arg 
            20                  25                  30          


Arg Gln His His Arg Val Gln Gln Gln Gly Arg Arg Gly Leu Gly Asp 
        35                  40                  45              


Arg Ala Ala Gly Gly Cys Leu Ser Leu Pro Ala Trp Lys Cys Cys Arg 
    50                  55                  60                  


Gly Val His His Leu Arg Pro Gly Gln Pro Asp Arg Gln Ala Ala Arg 
65                  70                  75                  80  


Trp Ile Arg Ile Gln Val Pro Gln Pro Pro Gln Pro Gly Gly His Gln 
                85                  90                  95      


Leu His Gly Ser 
            100 

<210>  3603
<211>  227
<212>  DNA
<213>  Homo sapiens

<400>  3603
ctctcgggtg gagtcttctg acagctggtg cgcctgcccg ggaacatcct cctggactca     60

atcatggctt gtggtctggt cgccagcaac ctgaatctca aacctggaga gtgccttcga    120

gtgcgaggcg aggtggctcc tgacgctaag agttaggtga ccttggacca gtcaaccaac    180

ctcacctagc ctcagtttgt tagaaaaaca aggggggagg tggttgt                  227


<210>  3604
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  3604


Met Ala Cys Gly Leu Val Ala Ser Asn Leu Asn Leu Lys Pro Gly Glu 
1               5                   10                  15      


Cys Leu Arg Val Arg Gly Glu Val Ala Pro Asp Ala Lys Ser 
            20                  25                  30  

<210>  3605
<211>  544
<212>  DNA
<213>  Homo sapiens

<400>  3605
ctctcgggtg gagtcttctg acagctggtg cgcctgcccg ggaacatcct cctggactca     60

atcatggctt gtggtctggt cgccagcaac ctgaatctca aacctggaga gtgccttcga    120

gtgcgaggcg aggtggctcc tgacgctaag agtgagttct tccagcaagc ttcgtgctga    180

acctgggcaa agacagcaac aacctgtgcc tgcacttcaa ccctcgcttc aacgcccacg    240

gcgacgccaa caccatcgtg tgcaacagca aggacggcgg ggcctggggg accgagcagc    300

gggaggctgt ctttcccttc cagcctggaa gtgttgcaga ggtgtgcatc accttcgacc    360

aggccaacct gaccgtcaag ctgccagatg gatacgaatt caagttcccc aaccgcctca    420

acctggaggc catcaactac atggcagctg acggtgactt caagatcaaa tgtgtggcct    480

ttgactgaaa tcagccagcc catggccccc aataaaggca gctgcctctg ctccctctga    540

acca                                                                 544


<210>  3606
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  3606


Met Ala Cys Gly Leu Val Ala Ser Asn Leu Asn Leu Lys Pro Gly Glu 
1               5                   10                  15      


Cys Leu Arg Val Arg Gly Glu Val Ala Pro Asp Ala Lys Ser Glu Phe 
            20                  25                  30          


Phe Gln Gln Ala Ser Cys 
        35              

<210>  3607
<211>  641
<212>  DNA
<213>  Homo sapiens

<400>  3607
ctgacagctg gtgcgcctgc ccgggaacat cctcctggac tcaatcatgg cttgtgcttc     60

cccttggctt ggtcagagga tgccgggcgg gaacaacccc actcccaccc ccagccaccc    120

ccggacactt cgagcagtgg aggccttgtc ctctaacccg gctgggccgg ggcttgtctg    180

tgcagggtct ggtcgccagc aacctgaatc tcaaacctgg agagtgcctt cgagtgcgag    240

gcgaggtggc tcctgacgct aagagcttcg tgctgaacct gggcaaagac agcaacaacc    300

tgtgcctgca cttcaaccct cgcttcaacg cccacggcga cgccaacacc atcgtgtgca    360

acagcaagga cggcggggcc tgggggaccg agcagcggga ggctgtcttt cccttccagc    420

ctggaagtgt tgcagaggtg tgcatcacct tcgaccaggc caacctgacc gtcaagctgc    480

cagatggata cgaattcaag ttccccaacc gcctcaacct ggaggccatc aactacatgg    540

cagctgacgg tgacttcaag atcaaatgtg tggcctttga ctgaaatcag ccagcccatg    600

gcccccaata aaggcagctg cctctgctcc ctctgaacca g                        641


<210>  3608
<211>  69
<212>  PRT
<213>  Homo sapiens

<400>  3608


Met Ala Cys Ala Ser Pro Trp Leu Gly Gln Arg Met Pro Gly Gly Asn 
1               5                   10                  15      


Asn Pro Thr Pro Thr Pro Ser His Pro Arg Thr Leu Arg Ala Val Glu 
            20                  25                  30          


Ala Leu Ser Ser Asn Pro Ala Gly Pro Gly Leu Val Cys Ala Gly Ser 
        35                  40                  45              


Gly Arg Gln Gln Pro Glu Ser Gln Thr Trp Arg Val Pro Ser Ser Ala 
    50                  55                  60                  


Arg Arg Gly Gly Ser 
65                  

<210>  3609
<211>  519
<212>  DNA
<213>  Homo sapiens

<400>  3609
gctccagaga acgctgaaaa gttgccagga cccgagacaa gctgcccagg atgggccctt     60

ctagggtctg gtcgccagca acctgaatct caaacctgga gagtgccttc gagtgcgagg    120

cgaggtggct cctgacgcta agagcttcgt gctgaacctg ggcaaagaca gcaacaacct    180

gtgcctgcac ttcaaccctc gcttcaacgc ccacggcgac gccaacacca tcgtgtgcaa    240

cagcaaggac ggcggggcct gggggaccga gcagcgggag gctgtctttc ccttccagcc    300

tggaagtgtt gcagaggtgt gcatcacctt cgaccaggcc aacctgaccg tcaagctgcc    360

agatggatac gaattcaagt tccccaaccg cctcaacctg gaggccatca actacatggc    420

agctgacggt gacttcaaga tcaaatgtgt ggcctttgac tgaaatcagc cagcccatgg    480

cccccaataa aggcagctgc ctctgctccc tctgaacca                           519


<210>  3610
<211>  50
<212>  PRT
<213>  Homo sapiens

<400>  3610


Met Asp Thr Asn Ser Ser Ser Pro Thr Ala Ser Thr Trp Arg Pro Ser 
1               5                   10                  15      


Thr Thr Trp Gln Leu Thr Val Thr Ser Arg Ser Asn Val Trp Pro Leu 
            20                  25                  30          


Thr Glu Ile Ser Gln Pro Met Ala Pro Asn Lys Gly Ser Cys Leu Cys 
        35                  40                  45              


Ser Leu 
    50  

<210>  3611
<211>  568
<212>  DNA
<213>  Homo sapiens

<400>  3611
tcagaggatg ccgggcggga acaaccccac tcccaccccc agccaccccc ggacacttcg     60

agcagtggag gccttgtcct ctaacccggc tgggccgggg cttgtctgtg cagggtctgg    120

tcgccagcaa cctgaatctc aaacctggag agtgccttcg agtgcgaggc gaggtggctc    180

ctgacgctaa gagcttcgtg ctgaacctgg gcaaagacag caacaacctg tgcctgcact    240

tcaaccctcg cttcaacgcc cacggcgacg ccaacaccat cgtgtgcaac agcaaggacg    300

gcggggcctg ggggaccgag cagcgggagg ctgtctttcc cttccagcct ggaagtgttg    360

cagaggtgtg catcaccttc gaccaggcca acctgaccgt caagctgcca gatggatacg    420

aattcaagtt ccccaaccgc ctcaacctgg aggccatcaa ctacatggca gctgacggtg    480

acttcaagat caaatgtgtg gcctttgact gaaatcagcc agcccatggc ccccaataaa    540

ggcagctgcc tctgctccct ctgaacca                                       568


<210>  3612
<211>  58
<212>  PRT
<213>  Homo sapiens

<400>  3612


Met Pro Gly Gly Asn Asn Pro Thr Pro Thr Pro Ser His Pro Arg Thr 
1               5                   10                  15      


Leu Arg Ala Val Glu Ala Leu Ser Ser Asn Pro Ala Gly Pro Gly Leu 
            20                  25                  30          


Val Cys Ala Gly Ser Gly Arg Gln Gln Pro Glu Ser Gln Thr Trp Arg 
        35                  40                  45              


Val Pro Ser Ser Ala Arg Arg Gly Gly Ser 
    50                  55              

<210>  3613
<211>  946
<212>  DNA
<213>  Homo sapiens

<400>  3613
gcgcccggga ggatgagtac gctacacccg gaagtgtctt cagggagagg aagccggcgg     60

cctcactgct atgggccgca acaagaagaa gaagcgagat ggtgacgacc ggcggccgag    120

gctcgttctt agcttcgacg aggagaagag gcgggagtac ctgacaggct tccacaagcg    180

gaaggtcgag cgaaagaagg cagccattga ggagattaag cagcggctga aagaggagca    240

gaggaagctt cgggaggagc gccaccagga atacttgaag atgctggcag agagagaaga    300

ggctctggag gaggcagatg agctggaccg gttggtgaca gcaaagacgg agtcggtgca    360

gtatgaccac cccaaccaca cagtcaccgt gaccaccatc agtgacctgg acctctcggg    420

ggcccggctg ctcgggctga ccccacctga gggaggggct ggagacaggt ctgaggagga    480

ggcgtcatcc acggagaaac caaccaaagc cttgcccagg aagtccagag accccctgct    540

ctctcagcgg atctcctccc tcacagcatc actacatgca cacagccgca aaaaggtcaa    600

gaggaaacat ccccgacggg cccaggactc caaaaagccc ccaagggccc ctcgtaccag    660

caaggcccag cgccgccgtc tcacaggcaa agcacggcac agcggggagt gagaccgaga    720

acgaagcggt gccccagtct aggctgcggg gacctgtcct tgctcagctt ggctgtccct    780

gtagcccagc ctgcacctag gtgtgcctac cgcatgttgc cgctgctgtt tctgctggga    840

cgtctgactc cagttccttc tcccctctcc agtgacaagg tcatttacaa cttacattta    900

caatttatag tgtttaccag tattaaattc tcagccactc ctttcc                   946


<210>  3614
<211>  213
<212>  PRT
<213>  Homo sapiens

<400>  3614


Met Gly Arg Asn Lys Lys Lys Lys Arg Asp Gly Asp Asp Arg Arg Pro 
1               5                   10                  15      


Arg Leu Val Leu Ser Phe Asp Glu Glu Lys Arg Arg Glu Tyr Leu Thr 
            20                  25                  30          


Gly Phe His Lys Arg Lys Val Glu Arg Lys Lys Ala Ala Ile Glu Glu 
        35                  40                  45              


Ile Lys Gln Arg Leu Lys Glu Glu Gln Arg Lys Leu Arg Glu Glu Arg 
    50                  55                  60                  


His Gln Glu Tyr Leu Lys Met Leu Ala Glu Arg Glu Glu Ala Leu Glu 
65                  70                  75                  80  


Glu Ala Asp Glu Leu Asp Arg Leu Val Thr Ala Lys Thr Glu Ser Val 
                85                  90                  95      


Gln Tyr Asp His Pro Asn His Thr Val Thr Val Thr Thr Ile Ser Asp 
            100                 105                 110         


Leu Asp Leu Ser Gly Ala Arg Leu Leu Gly Leu Thr Pro Pro Glu Gly 
        115                 120                 125             


Gly Ala Gly Asp Arg Ser Glu Glu Glu Ala Ser Ser Thr Glu Lys Pro 
    130                 135                 140                 


Thr Lys Ala Leu Pro Arg Lys Ser Arg Asp Pro Leu Leu Ser Gln Arg 
145                 150                 155                 160 


Ile Ser Ser Leu Thr Ala Ser Leu His Ala His Ser Arg Lys Lys Val 
                165                 170                 175     


Lys Arg Lys His Pro Arg Arg Ala Gln Asp Ser Lys Lys Pro Pro Arg 
            180                 185                 190         


Ala Pro Arg Thr Ser Lys Ala Gln Arg Arg Arg Leu Thr Gly Lys Ala 
        195                 200                 205             


Arg His Ser Gly Glu 
    210             

<210>  3615
<211>  8483
<212>  DNA
<213>  Homo sapiens

<400>  3615
gcgcccggga ggatgagtac gctacacccg gaagtgtctt cagggagagg aagccggcgg     60

cctcactgct atgggccgca acaagaagaa gaagcgagat ggtgacgacc ggcggccgag    120

gctcgttctt agcttcgacg aggagaagag gcgggagtac ctgacaggct tccacaagcg    180

gaaggtcgag cgaaagaagg cagccattga ggagattaag cagcggctga aagaggagca    240

gaggaagctt cgggaggagc gccaccagga atacttgaag atgctggcag agagagaaga    300

ggctctggag gaggcagatg agctggaccg gttggtgaca gcaaagacgg agtcggtgca    360

gtatgaccac cccaaccaca cagtcaccgt gaccaccatc agtgacctgg acctctcggg    420

ggcccggctg ctcgggctga ccccacctga gggaggggct ggagacaggt ctgaggagga    480

ggcgtcatcc acggagaaac caaccaaagc cttgcccagg aagtccagag accccctgct    540

ctctcagcgg atctcctccc tcacagcatc actacatgca cacagccgca aaaaggtcaa    600

gaggaaacat ccccgacggg cccaggactc caaaaagccc ccaagggccc ctcgtaccag    660

caaggcccag cgccgccgtc tcacaggcaa agcacggcac agcggggagt gagaccgaga    720

acgaagcggt gccccagtct aggctgcggg gacctgtcct tgctcagctt ggctgtccct    780

gtagcccagc ctgcacctag gtgtgcctac cgcatgttgc cgctgctgtt tctgctggga    840

cgtctgactc cagttccttc tcccctctcc agtgacaagg tctgatgatg gaggagcctt    900

ggccctggct gtcccagggg aggaggtgaa attcctcagc tctccaccaa gattggccac    960

aaaagcctga tcccctggaa cacagcaggc ctcacataga cggtcagcca ttggatcata   1020

ggaactgccc tggcctgact cacccaatat ggaggaggtg cctggggatg ccctgtgtga   1080

acactttgag gccaacatac ttacccagaa ccgctgtcaa aactgcttcc accctgagga   1140

ggcccatgga gcaagatacc aggagctcag gagcccttca ggtgctgagg tgccctactg   1200

cgacctgcct cgatgtccac ctgcccctga ggacccactc agcgcctcaa cctccggctg   1260

ccagtctgtg gtggacccag gcctcaggcc agggcccaag aggggcccat ccccctcagc   1320

agggctccca gaagagggtc ccacagctgc ccccaggagc aggagccggg agcttgaggc   1380

agtaccctat ctggagggcc tgaccacttc cttgtgtggc agctgcaacg aggaccccgg   1440

ctctgacccc acctccagcc ctgactccgc cacccctgat gataccagca actcgtcctc   1500

tgtggactgg gacactgttg agaggcagga ggaggaggcc cccagctggg acgagctcgc   1560

agtgatgatc ccgaggaggc ctcgggaggg gccgagagct gacagctccc aaagggctcc   1620

gtctctcctc accaggtccc ctgtgggagg agatgctgca ggccagaaaa aggaggacac   1680

cggcggtggg ggccggagcg caggacagca ctgggcaagg ctccggggag aaagcgggtt   1740

gtccctggag cggcaccggt caacactgac ccaggcttcc tccatgacac cacacagtgg   1800

acctcgaagc accacgtctc aggcttctcc tgcccaaagg gacactgctc aggctgcctc   1860

tacacgtgaa atccccagag cctcctctcc ccatcgaatc acccaaaggg acacctccag   1920

ggcctcatcc acccaacagg aaatctccag ggcctcatcc acccaacagg aaacctccag   1980

ggcctcatcc acccaagagg acacccctag ggcctcatcc acccaagagg acacccccag   2040

ggcctcatct acacagtgga acacccccag agcttcctct ccctcacgaa gcacccaact   2100

ggataacccc agaacctctt ctacccagca ggacaacccc caaacttctt ttcctacttg   2160

tactccccag cgggaaaacc ccaggacacc ctgtgtccag caggacgatc ccagagcctc   2220

ctctcccaac agaaccactc aacgagagaa ttccagaaca tcctgtgccc agcgggacaa   2280

tcccaaagcc tccagaacct cctctcccaa tagagccaca cgagacaacc ccagaacatc   2340

ctgcgcccag cgggacaatc ccagagcctc ctctcccagt agagctacac gagacaaccc   2400

cacaacatcc tgtgcccagc gggacaatcc cagagcctcc agaacctcct ctcccaatag   2460

agccacacga gacaacccca gaacatcctg tgcccagcgg gacaatccca gagcctcctc   2520

tcccagtaga gctacacgag acaaccccac aacatcctgt gcccagcggg acaatcccag   2580

agcctccaga acctcctctc ccaatagagc cacacgagac aaccccagaa catcctgcgc   2640

ccagcgggac aatcccagag cctcctctcc caatagagct gcacgagaca accccacaac   2700

atcctgtgcc cagcgggaca atcccagagc ctccagaacc tcctctccca atagagccac   2760

acgagacaac cccagaacat cctgtgccca gcgggacaat cccagagcct cctctcccaa   2820

tagagctaca cgagacaacc ccacaacatc ctgtgcccag cgggacaatc ccagagcctc   2880

cagaacctcc tctcccaata gagccacacg agataacccc agaacatcct gtgcccagcg   2940

ggacaatccc agagcctcct ctcccaacag aaccacccaa caagacagcc ccagaacatc   3000

ctgtgcccga cgggacgatc ccagagcctc ctctcctaac agaaccatcc aacaagagaa   3060

ccccagaaca tcctgtgccc tacgggacaa tcccagagcc tcctctccca gcagaaccat   3120

ccaacaagag aaccccagaa catcctgtgc ccaacgggac gatcccagag cctcctctcc   3180

taacagaacc acccaacaag agaaccccag aacatcctgt gcccgacggg acaatcccag   3240

agcctcctct cgcaacagaa ccatccagcg agacaacccc agaacatcct gtgcccagcg   3300

ggacaatccc agagcctcct ctcctaacag aaccatccaa caagagaacc tcagaacatc   3360

ctgtacccga caggacaatc ccaggacctc ctctcccaat agagccacac gagacaaccc   3420

cagaacatcc tgtgcccagc gggacaatct cagagcctcc tctcccatca gagccaccca   3480

acaggacaac cccagaactt gtattcaaca gaacatcccc agatcatctt ctacccaaca   3540

agacaaccct aaaacctctt gtaccaaacg agataacctc agacccactt gtacacagcg   3600

ggaccgcaca cagtcctttt cctttcaacg agacaaccct ggaacctcct catctcaatg   3660

ctgcacccaa aaggagaatc tgagaccatc atctccccac cgctccactc aatggaacaa   3720

tcccaggaat tcatctcccc atcgtactaa caaagacatc ccctgggcct cgtttcccct   3780

ccggccaact cagagtgatg gtccccgaac ctcttcccca tctcgctcca agcaaagcga   3840

ggttccctgg gcatccatcg ccctccggcc aacccaaggt gacaggcctc agacatcctc   3900

tcccagcagg ccagcccagc atgacccacc ccagtcctcc tttggcccca cccagtacaa   3960

cttgccatcc cgggccacct cttcctccca taacccaggc caccagagca cctcccgaac   4020

ttcctcacct gtgtaccccg ctgcctatgg ggctcccctg acctctcctg agccctccca   4080

gcctccatgt gctgtgtgca ttgggcaccg ggatgcccct cgagcctctt cgccccctcg   4140

ctatttgcag cacgacccct tccccttctt cccagagccc cgcgcccctg agagtgaacc   4200

gccccaccac gagcctccct atataccacc tgctgtgtgc attggacacc gagatgcccc   4260

ccgggcgtcc tcgccccccc gccacaccca atttgacccc ttccccttcc tcccagacac   4320

atcagatgcc gagcatcagt gtcagtcccc ccaacacgag ccccttcagc tccctgcacc   4380

tgtgtgtatt gggtaccgag atgcaccccg ggcctcctcc ccaccacgcc aggccccaga   4440

gccttccctc ttattccagg acctccccag ggccagcaca gagagccttg tcccttccat   4500

ggactctctg cacgagtgcc cccacatccc cacccctgtg tgcattgggc accgggatgc   4560

accctccttc tcatccccac cacgccaggc tcctgagcca tccctcttct tccaggatcc   4620

ccctggaact agtatggaga gcctggcccc ctccactgac tctctgcatg gctccccagt   4680

gctgatcccc caagtgtgca tcgggcaccg ggatgcaccc cgagcctcct ccccaccccg   4740

ccacccaccc agtgacctag cgttcctggc accctcacct tcaccgggca gctctggggg   4800

ctcccggggc tcagcgcctc ccggggagac caggcacaac ttggagcggg aggagtacac   4860

tgtgctggcc gacctgcccc cacccaggag gctggcccag agacagccag ggccccaggc   4920

gcagtgcagc agcgggggcc gcacccacag ccctggccgt gcagaggtgg agcgcctctt   4980

cgggcaagag cgcaggtgac catgctccct gccaaacagg cagaactgac ccggcggagc   5040

caagcagagc cccctcatcc ttggagtcct gagaagagac ctgagggaga tcggcagctc   5100

caggggtccc cgctgccccc caggacatca gccaggaccc ctgagaggga gctgcggaca   5160

cagagacctc tggagagtgg ccaagcaggc ccaagacagc ctctgggggt gtggcagagt   5220

caggaggaac cgccagggtc ccagggccct catagacacc tagaaaggag ctggagcagc   5280

caggagggag gcctgggccc tgggggctgg tggggatgtg gagagcccag cctgggggca   5340

gccaaagccc cggagggagc atgggggggc acttccaggg agtacaagga gagctggggg   5400

cagccagagg cctgggagga gaagcccact catgagctcc ccagagaact aggaaagaga   5460

agcccactca cgagcccccc tgagaactgg ggaggccccg cagagtcctc acaatcctgg   5520

cactctggga cacccactgc tgtgggctgg ggggcagagg gagcgtgtcc atacccgcgt   5580

ggctctgaga ggcgacccga gcttgactgg agggatctgc ttggccttct ccgggcacca   5640

ggagaggggg tctgggcccg tgtccccagc ctggactggg agggcctctt ggagctcctg   5700

caggccaggc tgccccgcaa ggacccagct ggacacaggg atgacctggc cagggcttta   5760

gggccagagc tgggtccccc aggcacaaac gatgtccctg agcaggagtc acacagccag   5820

ccagaaggct gggccgaggc caccccagtc aatggacaca gccccgcact gcagtcccag   5880

agcccggtcc agctgcccag ccctgcctgc acctccaccc agtggccaaa gatcaaagtg   5940

acaagaggac cagcgaccgc aactctggca ggcctggagc agacgggccc cctggggagc   6000

aggagcactg cgaagggccc cagcttgcca gagctgcagt tccaaccaga ggagcctgag   6060

gagtcagaac caagcagagg ccaagacccc ctgactgacc agaagcaggc agactcgccc   6120

gatctgctca acttcaagaa gggatggatg tcgatcttgg acgagcctgg agagtggaag   6180

aaacattggt ttgtgctgac agattcaagt ctcaaatatt acagagactc cactgctgag   6240

gaggcagatg agctggatgg tgagatcgac ctgcgttcct gcacggatgt cactgagtac   6300

gcggtgcagc gcaactatgg cttccagatc cacaccaagg atgctgtcta taccttgtcg   6360

gccatgacct caggcatccg gcggaactgg atcgaggctc tgagaaagac cgtacgtcca   6420

acttcagccc cagatgtcac caagctctcg gactctaaca aggagaacgc gctgcacagc   6480

tacagcaccc agaagggccc cctgaaggca ggggagcagc gggcgggctc tgaggtcatc   6540

agccggggtg gccctcggaa ggcggacggg cagcgtcagg ccttggacta cgtggagctc   6600

tcgccgctga cccaggcttc cccgcagcgg gcccgcaccc cagcccgcac tcctgaccgc   6660

ctggccaagc aggaggagct ggagcgggac ctggcccagc gctccgagga gcggcgcaag   6720

tggtttgagg ccacagacag caggacccca gaggtgcctg ctggtgaggg gccgcgccgg   6780

ggcctgggtg cccccctgac tgaggaccag caaaaccggc ttagtgagga gatcgagaag   6840

aagtggcagg agctggagaa gctgcccctg cgggagaata agcgggtgcc cctcactgcc   6900

ctgctcaacc aaagccgcgg agagcgccga gggcccccaa gtgacggcca cgaggcactg   6960

gagaaggagg ttcaggctct tcgggcccag ctggaggcgt ggcgtctcca aggggaggct   7020

cctcagagtg cactgagatc ccaggaggat ggccacatcc ccccgggcta catctcacag   7080

gaggcatgtg agcgcagcct ggcagagatg gagtcctcgc accagcaggt gatggaggag   7140

ctgcagcggc accacgagcg ggagctgcag cgcctgcagc aggagaagga gtggctcctg   7200

gctgaggaga cggcagccac ggcctcagcc attgaagcca tgaagaaggc ctaccaggaa   7260

gagctgagcc gagagctgag caaaacacgg agtctccagc agggcccgga tggcctccgg   7320

aagcagcacc agtcagatgt ggaggcactg aagcgagagc tgcaggtgct atcggagcag   7380

tactcgcaga agtgcctgga gattggggca ctcatgcggc aggctgagga gcgcgagcac   7440

acgctgcgcc gctgccagca ggagggccag gagctgctgc gccacaacca ggagctgcat   7500

ggccgcctgt cagaggagat agaccagctg cgcggcttca ttgcctcgca gggcatgggc   7560

aatggctgcg ggcgcagcaa cgagcggagt tcctgcgagc tagaggtgct gcttcgcgta   7620

aaagaaaacg aactccagta cctaaagaag gaggtgcagt gcctccggga cgagctccag   7680

atgatgcaga aggacaagcg cttcacctcg ggaaagtacc aggacgtcta tgtggagctg   7740

agccacatca agacacggtc tgagcgggag atcgagcagc tgaaggagca cctgcgtctt   7800

gccatggccg ccctccagga gaaggagtcg atgcgcaaca gcctggctga gtagaggtcc   7860

cgcccagctg cagaccctcc aggctggagg accagccgcc ctccttccct cctggatgga   7920

agtaaaaagc caagctttct ccccaccctc tgtgggccac acgtgcactt gcacccactg   7980

catatctgag cgcgcccctc gcactgggtc tcaccttgca ccttcttcag gattttatat   8040

gtgaagagat ttttatatag atttttttcc tttttttcca aaacacttta tactttaaaa   8100

aaaaaaaaaa aaagcaattc ctggtggctg tgtgcctcca accctggtcc ccctctgtct   8160

ccagccaccc tctgcttggg cttctgagct ggtggccctg gcccagaggt ctggcggagg   8220

cccaggcagc agccatggcg gggtgtctct acaggggaga ggcgggagcc tgccaccctc   8280

ttcctgccct acctcctact aacacttcct gccccatttg gacccgtacc atggggctca   8340

ggacagaggg agctagcagc tggcctccat ggccccacag cctccttcga ggctgtgctg   8400

ggtgcagaac cgccagagcc acccaaaagg tgtttctctt ctgctccctg aacctcttaa   8460

cttaataaaa cgttccagca gct                                           8483


<210>  3616
<211>  1316
<212>  PRT
<213>  Homo sapiens

<400>  3616


Met Glu Glu Val Pro Gly Asp Ala Leu Cys Glu His Phe Glu Ala Asn 
1               5                   10                  15      


Ile Leu Thr Gln Asn Arg Cys Gln Asn Cys Phe His Pro Glu Glu Ala 
            20                  25                  30          


His Gly Ala Arg Tyr Gln Glu Leu Arg Ser Pro Ser Gly Ala Glu Val 
        35                  40                  45              


Pro Tyr Cys Asp Leu Pro Arg Cys Pro Pro Ala Pro Glu Asp Pro Leu 
    50                  55                  60                  


Ser Ala Ser Thr Ser Gly Cys Gln Ser Val Val Asp Pro Gly Leu Arg 
65                  70                  75                  80  


Pro Gly Pro Lys Arg Gly Pro Ser Pro Ser Ala Gly Leu Pro Glu Glu 
                85                  90                  95      


Gly Pro Thr Ala Ala Pro Arg Ser Arg Ser Arg Glu Leu Glu Ala Val 
            100                 105                 110         


Pro Tyr Leu Glu Gly Leu Thr Thr Ser Leu Cys Gly Ser Cys Asn Glu 
        115                 120                 125             


Asp Pro Gly Ser Asp Pro Thr Ser Ser Pro Asp Ser Ala Thr Pro Asp 
    130                 135                 140                 


Asp Thr Ser Asn Ser Ser Ser Val Asp Trp Asp Thr Val Glu Arg Gln 
145                 150                 155                 160 


Glu Glu Glu Ala Pro Ser Trp Asp Glu Leu Ala Val Met Ile Pro Arg 
                165                 170                 175     


Arg Pro Arg Glu Gly Pro Arg Ala Asp Ser Ser Gln Arg Ala Pro Ser 
            180                 185                 190         


Leu Leu Thr Arg Ser Pro Val Gly Gly Asp Ala Ala Gly Gln Lys Lys 
        195                 200                 205             


Glu Asp Thr Gly Gly Gly Gly Arg Ser Ala Gly Gln His Trp Ala Arg 
    210                 215                 220                 


Leu Arg Gly Glu Ser Gly Leu Ser Leu Glu Arg His Arg Ser Thr Leu 
225                 230                 235                 240 


Thr Gln Ala Ser Ser Met Thr Pro His Ser Gly Pro Arg Ser Thr Thr 
                245                 250                 255     


Ser Gln Ala Ser Pro Ala Gln Arg Asp Thr Ala Gln Ala Ala Ser Thr 
            260                 265                 270         


Arg Glu Ile Pro Arg Ala Ser Ser Pro His Arg Ile Thr Gln Arg Asp 
        275                 280                 285             


Thr Ser Arg Ala Ser Ser Thr Gln Gln Glu Ile Ser Arg Ala Ser Ser 
    290                 295                 300                 


Thr Gln Gln Glu Thr Ser Arg Ala Ser Ser Thr Gln Glu Asp Thr Pro 
305                 310                 315                 320 


Arg Ala Ser Ser Thr Gln Glu Asp Thr Pro Arg Ala Ser Ser Thr Gln 
                325                 330                 335     


Trp Asn Thr Pro Arg Ala Ser Ser Pro Ser Arg Ser Thr Gln Leu Asp 
            340                 345                 350         


Asn Pro Arg Thr Ser Ser Thr Gln Gln Asp Asn Pro Gln Thr Ser Phe 
        355                 360                 365             


Pro Thr Cys Thr Pro Gln Arg Glu Asn Pro Arg Thr Pro Cys Val Gln 
    370                 375                 380                 


Gln Asp Asp Pro Arg Ala Ser Ser Pro Asn Arg Thr Thr Gln Arg Glu 
385                 390                 395                 400 


Asn Ser Arg Thr Ser Cys Ala Gln Arg Asp Asn Pro Lys Ala Ser Arg 
                405                 410                 415     


Thr Ser Ser Pro Asn Arg Ala Thr Arg Asp Asn Pro Arg Thr Ser Cys 
            420                 425                 430         


Ala Gln Arg Asp Asn Pro Arg Ala Ser Ser Pro Ser Arg Ala Thr Arg 
        435                 440                 445             


Asp Asn Pro Thr Thr Ser Cys Ala Gln Arg Asp Asn Pro Arg Ala Ser 
    450                 455                 460                 


Arg Thr Ser Ser Pro Asn Arg Ala Thr Arg Asp Asn Pro Arg Thr Ser 
465                 470                 475                 480 


Cys Ala Gln Arg Asp Asn Pro Arg Ala Ser Ser Pro Ser Arg Ala Thr 
                485                 490                 495     


Arg Asp Asn Pro Thr Thr Ser Cys Ala Gln Arg Asp Asn Pro Arg Ala 
            500                 505                 510         


Ser Arg Thr Ser Ser Pro Asn Arg Ala Thr Arg Asp Asn Pro Arg Thr 
        515                 520                 525             


Ser Cys Ala Gln Arg Asp Asn Pro Arg Ala Ser Ser Pro Asn Arg Ala 
    530                 535                 540                 


Ala Arg Asp Asn Pro Thr Thr Ser Cys Ala Gln Arg Asp Asn Pro Arg 
545                 550                 555                 560 


Ala Ser Arg Thr Ser Ser Pro Asn Arg Ala Thr Arg Asp Asn Pro Arg 
                565                 570                 575     


Thr Ser Cys Ala Gln Arg Asp Asn Pro Arg Ala Ser Ser Pro Asn Arg 
            580                 585                 590         


Ala Thr Arg Asp Asn Pro Thr Thr Ser Cys Ala Gln Arg Asp Asn Pro 
        595                 600                 605             


Arg Ala Ser Arg Thr Ser Ser Pro Asn Arg Ala Thr Arg Asp Asn Pro 
    610                 615                 620                 


Arg Thr Ser Cys Ala Gln Arg Asp Asn Pro Arg Ala Ser Ser Pro Asn 
625                 630                 635                 640 


Arg Thr Thr Gln Gln Asp Ser Pro Arg Thr Ser Cys Ala Arg Arg Asp 
                645                 650                 655     


Asp Pro Arg Ala Ser Ser Pro Asn Arg Thr Ile Gln Gln Glu Asn Pro 
            660                 665                 670         


Arg Thr Ser Cys Ala Leu Arg Asp Asn Pro Arg Ala Ser Ser Pro Ser 
        675                 680                 685             


Arg Thr Ile Gln Gln Glu Asn Pro Arg Thr Ser Cys Ala Gln Arg Asp 
    690                 695                 700                 


Asp Pro Arg Ala Ser Ser Pro Asn Arg Thr Thr Gln Gln Glu Asn Pro 
705                 710                 715                 720 


Arg Thr Ser Cys Ala Arg Arg Asp Asn Pro Arg Ala Ser Ser Arg Asn 
                725                 730                 735     


Arg Thr Ile Gln Arg Asp Asn Pro Arg Thr Ser Cys Ala Gln Arg Asp 
            740                 745                 750         


Asn Pro Arg Ala Ser Ser Pro Asn Arg Thr Ile Gln Gln Glu Asn Leu 
        755                 760                 765             


Arg Thr Ser Cys Thr Arg Gln Asp Asn Pro Arg Thr Ser Ser Pro Asn 
    770                 775                 780                 


Arg Ala Thr Arg Asp Asn Pro Arg Thr Ser Cys Ala Gln Arg Asp Asn 
785                 790                 795                 800 


Leu Arg Ala Ser Ser Pro Ile Arg Ala Thr Gln Gln Asp Asn Pro Arg 
                805                 810                 815     


Thr Cys Ile Gln Gln Asn Ile Pro Arg Ser Ser Ser Thr Gln Gln Asp 
            820                 825                 830         


Asn Pro Lys Thr Ser Cys Thr Lys Arg Asp Asn Leu Arg Pro Thr Cys 
        835                 840                 845             


Thr Gln Arg Asp Arg Thr Gln Ser Phe Ser Phe Gln Arg Asp Asn Pro 
    850                 855                 860                 


Gly Thr Ser Ser Ser Gln Cys Cys Thr Gln Lys Glu Asn Leu Arg Pro 
865                 870                 875                 880 


Ser Ser Pro His Arg Ser Thr Gln Trp Asn Asn Pro Arg Asn Ser Ser 
                885                 890                 895     


Pro His Arg Thr Asn Lys Asp Ile Pro Trp Ala Ser Phe Pro Leu Arg 
            900                 905                 910         


Pro Thr Gln Ser Asp Gly Pro Arg Thr Ser Ser Pro Ser Arg Ser Lys 
        915                 920                 925             


Gln Ser Glu Val Pro Trp Ala Ser Ile Ala Leu Arg Pro Thr Gln Gly 
    930                 935                 940                 


Asp Arg Pro Gln Thr Ser Ser Pro Ser Arg Pro Ala Gln His Asp Pro 
945                 950                 955                 960 


Pro Gln Ser Ser Phe Gly Pro Thr Gln Tyr Asn Leu Pro Ser Arg Ala 
                965                 970                 975     


Thr Ser Ser Ser His Asn Pro Gly His Gln Ser Thr Ser Arg Thr Ser 
            980                 985                 990         


Ser Pro Val Tyr Pro Ala Ala Tyr  Gly Ala Pro Leu Thr  Ser Pro Glu 
        995                 1000                 1005             


Pro Ser  Gln Pro Pro Cys Ala  Val Cys Ile Gly His  Arg Asp Ala 
    1010                 1015                 1020             


Pro Arg  Ala Ser Ser Pro Pro  Arg Tyr Leu Gln His  Asp Pro Phe 
    1025                 1030                 1035             


Pro Phe  Phe Pro Glu Pro Arg  Ala Pro Glu Ser Glu  Pro Pro His 
    1040                 1045                 1050             


His Glu  Pro Pro Tyr Ile Pro  Pro Ala Val Cys Ile  Gly His Arg 
    1055                 1060                 1065             


Asp Ala  Pro Arg Ala Ser Ser  Pro Pro Arg His Thr  Gln Phe Asp 
    1070                 1075                 1080             


Pro Phe  Pro Phe Leu Pro Asp  Thr Ser Asp Ala Glu  His Gln Cys 
    1085                 1090                 1095             


Gln Ser  Pro Gln His Glu Pro  Leu Gln Leu Pro Ala  Pro Val Cys 
    1100                 1105                 1110             


Ile Gly  Tyr Arg Asp Ala Pro  Arg Ala Ser Ser Pro  Pro Arg Gln 
    1115                 1120                 1125             


Ala Pro  Glu Pro Ser Leu Leu  Phe Gln Asp Leu Pro  Arg Ala Ser 
    1130                 1135                 1140             


Thr Glu  Ser Leu Val Pro Ser  Met Asp Ser Leu His  Glu Cys Pro 
    1145                 1150                 1155             


His Ile  Pro Thr Pro Val Cys  Ile Gly His Arg Asp  Ala Pro Ser 
    1160                 1165                 1170             


Phe Ser  Ser Pro Pro Arg Gln  Ala Pro Glu Pro Ser  Leu Phe Phe 
    1175                 1180                 1185             


Gln Asp  Pro Pro Gly Thr Ser  Met Glu Ser Leu Ala  Pro Ser Thr 
    1190                 1195                 1200             


Asp Ser  Leu His Gly Ser Pro  Val Leu Ile Pro Gln  Val Cys Ile 
    1205                 1210                 1215             


Gly His  Arg Asp Ala Pro Arg  Ala Ser Ser Pro Pro  Arg His Pro 
    1220                 1225                 1230             


Pro Ser  Asp Leu Ala Phe Leu  Ala Pro Ser Pro Ser  Pro Gly Ser 
    1235                 1240                 1245             


Ser Gly  Gly Ser Arg Gly Ser  Ala Pro Pro Gly Glu  Thr Arg His 
    1250                 1255                 1260             


Asn Leu  Glu Arg Glu Glu Tyr  Thr Val Leu Ala Asp  Leu Pro Pro 
    1265                 1270                 1275             


Pro Arg  Arg Leu Ala Gln Arg  Gln Pro Gly Pro Gln  Ala Gln Cys 
    1280                 1285                 1290             


Ser Ser  Gly Gly Arg Thr His  Ser Pro Gly Arg Ala  Glu Val Glu 
    1295                 1300                 1305             


Arg Leu  Phe Gly Gln Glu Arg  Arg 
    1310                 1315     

<210>  3617
<211>  10646
<212>  DNA
<213>  Homo sapiens

<400>  3617
gcgcccggga ggatgagtac gctacacccg gaagtgtctt cagggagagg aagccggcgg     60

cctcactgct atgggccgca acaagaagaa gaagcgagat ggtgacgacc ggcggccgag    120

gctcgttctt agcttcgacg aggagaagag gcgggagtac ctgacaggct tccacaagcg    180

gaaggtcgag cgaaagaagg cagccattga ggagattaag cagcggctga aagaggagca    240

gaggaagctt cgggaggagc gccaccagga atacttgaag atgctggcag agagagaaga    300

ggctctggag gaggcagatg agctggaccg gttggtgaca gcaaagacgg agtcggtgca    360

gtatgaccac cccaaccaca cagtcaccgt gaccaccatc agtgacctgg acctctcggg    420

ggcccggctg ctcgggctga ccccacctga gggaggggct ggagacaggt ctgaggagga    480

ggcgtcatcc acggagaaac caaccaaagc cttgcccagg aagtccagag accccctgct    540

ctctcagcgg atctcctccc tcacagcatc actacatgca cacagccgca aaaaggtcaa    600

gaggaaacat ccccgacggg cccaggactc caaaaagccc ccaagggccc ctcgtaccag    660

caaggcccag cgccgccgtc tcacaggcaa agcacggcac agcggggagt gagaccgaga    720

acgaagcggt gccccagtct aggctgcggg gacctgtcct tgctcagctt ggctgtccct    780

gtagcccagc ctgcacctag gtgtgcctac cgcatgttgc cgctgctgtt tctgctggga    840

cgtctgactc cagttccttc tcccctctcc agtgacaagg tctgatgatg gaggagcctt    900

ggccctggct gtcccagggg aggaggtgaa attcctcagc tctccaccaa gattggccac    960

aaaagcctga tcccctggaa cacagcaggc ctcacataga cggtcagcca ttggatcata   1020

ggaactgccc tggcctgact cacccaatat ggaggaggtg cctggggatg ccctgtgtga   1080

acactttgag gccaacatac ttacccagaa ccgctgtcaa aactgcttcc accctgagga   1140

ggcccatgga gcaagatacc aggagctcag gagcccttca ggtgctgagg tgccctactg   1200

cgacctgcct cgatgtccac ctgcccctga ggacccactc agcgcctcaa cctccggctg   1260

ccagtctgtg gtggacccag gcctcaggcc agggcccaag aggggcccat ccccctcagc   1320

agggctccca gaagagggtc ccacagctgc ccccaggagc aggagccggg agcttgaggc   1380

agtaccctat ctggagggcc tgaccacttc cttgtgtggc agctgcaacg aggaccccgg   1440

ctctgacccc acctccagcc ctgactccgc cacccctgat gataccagca actcgtcctc   1500

tgtggactgg gacactgttg agaggcagga ggaggaggcc cccagctggg acgagctcgc   1560

agtgatgatc ccgaggaggc ctcgggaggg gccgagagct gacagctccc aaagggctcc   1620

gtctctcctc accaggtccc ctgtgggagg agatgctgca ggccagaaaa aggaggacac   1680

cggcggtggg ggccggagcg caggacagca ctgggcaagg ctccggggag aaagcgggtt   1740

gtccctggag cggcaccggt caacactgac ccaggcttcc tccatgacac cacacagtgg   1800

acctcgaagc accacgtctc aggcttctcc tgcccaaagg gacactgctc aggctgcctc   1860

tacacgtgaa atccccagag cctcctctcc ccatcgaatc acccaaaggg acacctccag   1920

ggcctcatcc acccaacagg aaatctccag ggcctcatcc acccaacagg aaacctccag   1980

ggcctcatcc acccaagagg acacccctag ggcctcatcc acccaagagg acacccccag   2040

ggcctcatct acacagtgga acacccccag agcttcctct ccctcacgaa gcacccaact   2100

ggataacccc agaacctctt ctacccagca ggacaacccc caaacttctt ttcctacttg   2160

tactccccag cgggaaaacc ccaggacacc ctgtgtccag caggacgatc ccagagcctc   2220

ctctcccaac agaaccactc aacgagagaa ttccagaaca tcctgtgccc agcgggacaa   2280

tcccaaagcc tccagaacct cctctcccaa tagagccaca cgagacaacc ccagaacatc   2340

ctgcgcccag cgggacaatc ccagagcctc ctctcccagt agagctacac gagacaaccc   2400

cacaacatcc tgtgcccagc gggacaatcc cagagcctcc agaacctcct ctcccaatag   2460

agccacacga gacaacccca gaacatcctg tgcccagcgg gacaatccca gagcctcctc   2520

tcccagtaga gctacacgag acaaccccac aacatcctgt gcccagcggg acaatcccag   2580

agcctccaga acctcctctc ccaatagagc cacacgagac aaccccagaa catcctgcgc   2640

ccagcgggac aatcccagag cctcctctcc caatagagct gcacgagaca accccacaac   2700

atcctgtgcc cagcgggaca atcccagagc ctccagaacc tcctctccca atagagccac   2760

acgagacaac cccagaacat cctgtgccca gcgggacaat cccagagcct cctctcccaa   2820

tagagctaca cgagacaacc ccacaacatc ctgtgcccag cgggacaatc ccagagcctc   2880

cagaacctcc tctcccaata gagccacacg agataacccc agaacatcct gtgcccagcg   2940

ggacaatccc agagcctcct ctcccaacag aaccacccaa caagacagcc ccagaacatc   3000

ctgtgcccga cgggacgatc ccagagcctc ctctcctaac agaaccatcc aacaagagaa   3060

ccccagaaca tcctgtgccc tacgggacaa tcccagagcc tcctctccca gcagaaccat   3120

ccaacaagag aaccccagaa catcctgtgc ccaacgggac gatcccagag cctcctctcc   3180

taacagaacc acccaacaag agaaccccag aacatcctgt gcccgacggg acaatcccag   3240

agcctcctct cgcaacagaa ccatccagcg agacaacccc agaacatcct gtgcccagcg   3300

ggacaatccc agagcctcct ctcctaacag aaccatccaa caagagaacc tcagaacatc   3360

ctgtacccga caggacaatc ccaggacctc ctctcccaat agagccacac gagacaaccc   3420

cagaacatcc tgtgcccagc gggacaatct cagagcctcc tctcccatca gagccaccca   3480

acaggacaac cccagaactt gtattcaaca gaacatcccc agatcatctt ctacccaaca   3540

agacaaccct aaaacctctt gtaccaaacg agataacctc agacccactt gtacacagcg   3600

ggaccgcaca cagtcctttt cctttcaacg agacaaccct ggaacctcct catctcaatg   3660

ctgcacccaa aaggagaatc tgagaccatc atctccccac cgctccactc aatggaacaa   3720

tcccaggaat tcatctcccc atcgtactaa caaagacatc ccctgggcct cgtttcccct   3780

ccggccaact cagagtgatg gtccccgaac ctcttcccca tctcgctcca agcaaagcga   3840

ggttccctgg gcatccatcg ccctccggcc aacccaaggt gacaggcctc agacatcctc   3900

tcccagcagg ccagcccagc atgacccacc ccagtcctcc tttggcccca cccagtacaa   3960

cttgccatcc cgggccacct cttcctccca taacccaggc caccagagca cctcccgaac   4020

ttcctcacct gtgtaccccg ctgcctatgg ggctcccctg acctctcctg agccctccca   4080

gcctccatgt gctgtgtgca ttgggcaccg ggatgcccct cgagcctctt cgccccctcg   4140

ctatttgcag cacgacccct tccccttctt cccagagccc cgcgcccctg agagtgaacc   4200

gccccaccac gagcctccct atataccacc tgctgtgtgc attggacacc gagatgcccc   4260

ccgggcgtcc tcgccccccc gccacaccca atttgacccc ttccccttcc tcccagacac   4320

atcagatgcc gagcatcagt gtcagtcccc ccaacacgag ccccttcagc tccctgcacc   4380

tgtgtgtatt gggtaccgag atgcaccccg ggcctcctcc ccaccacgcc aggccccaga   4440

gccttccctc ttattccagg acctccccag ggccagcaca gagagccttg tcccttccat   4500

ggactctctg cacgagtgcc cccacatccc cacccctgtg tgcattgggc accgggatgc   4560

accctccttc tcatccccac cacgccaggc tcctgagcca tccctcttct tccaggatcc   4620

ccctggaact agtatggaga gcctggcccc ctccactgac tctctgcatg gctccccagt   4680

gctgatcccc caagtgtgca tcgggcaccg ggatgcaccc cgagcctcct ccccaccccg   4740

ccacccaccc agtgacctag cgttcctggc accctcacct tcaccgggca gctctggggg   4800

ctcccggggc tcagcgcctc ccggggagac caggcacaac ttggagcggg aggagtacac   4860

tgtgctggcc gacctgcccc cacccaggag gctggcccag agacagccag ggccccaggc   4920

gcagtgcagc agcgggggcc gcacccacag ccctggccgt gcagaggtgg agcgcctctt   4980

cgggcaagag cgcaggtgac catgctccct gccaaacagg cagaactgac ccggcggagc   5040

caagcagagc cccctcatcc ttggagtcct gagaagagac ctgagggaga tcggcagctc   5100

caggggtccc cgctgccccc caggacatca gccaggaccc ctgagaggga gctgcggaca   5160

cagagacctc tggagagtgg ccaagcaggc ccaagacagc ctctgggggt gtggcagagt   5220

caggaggaac cgccagggtc ccagggccct catagacacc tagaaaggag ctggagcagc   5280

caggagggag gcctgggccc tgggggctgg tggggatgtg gagagcccag cctgggggca   5340

gccaaagccc cggagggagc atgggggggc acttccaggg agtacaagga gagctggggg   5400

cagccagagg cctgggagga gaagcccact catgagctcc ccagagaact aggaaagaga   5460

agcccactca cgagcccccc tgagaactgg ggaggccccg cagagtcctc acaatcctgg   5520

cactctggga cacccactgc tgtgggctgg ggggcagagg gagcgtgtcc atacccgcgt   5580

ggctctgaga ggcgacccga gcttgactgg agggatctgc ttggccttct ccgggcacca   5640

ggagaggggg tctgggcccg tgtccccagc ctggactggg agggcctctt ggagctcctg   5700

caggccaggc tgccccgcaa ggacccagct ggacacaggg atgacctggc cagggcttta   5760

gggccagagc tgggtccccc aggcacaaac gatgtccctg agcaggagtc acacagccag   5820

ccagaaggct gggccgaggc caccccagtc aatggacaca gccccgcact gcagtcccag   5880

agcccggtcc agctgcccag ccctgcctgc acctccaccc agtggccaaa gatcaaagtg   5940

acaagaggac cagcgaccgc aactctggca ggcctggagc agacgggccc cctggggagc   6000

aggagcactg cgaagggccc cagcttgcca gagctgcagt tccaaccaga ggagcctgag   6060

gagtcagaac caagcagagg ccaagacccc ctgactgacc agaagcaggc agactcgccc   6120

gatctgctca acttcaagaa gggatggatg tcgatcttgg acgagcctgg agagtggaag   6180

aaacattggt ttgtgctgac agattcaagt ctcaaatatt acagagactc cactgctgag   6240

gaggcagatg agctggatgg tgagatcgac ctgcgttcct gcacggatgt cactgagtac   6300

gcggtgcagc gcaactatgg cttccagatc cacaccaagg atgctgtcta taccttgtcg   6360

gccatgacct caggcatccg gcggaactgg atcgaggctc tgagaaagac cgtacgtcca   6420

acttcagccc cagatgtcac caagctctcg gactctaaca aggagaacgc gctgcacagc   6480

tacagcaccc agaagggccc cctgaaggca ggggagcagc gggcgggctc tgaggtcatc   6540

agccggggtg gccctcggaa ggcggacggg cagcgtcagg ccttggacta cgtggagctc   6600

tcgccgctga cccaggcttc cccgcagcgg gcccgcaccc cagcccgcac tcctgaccgc   6660

ctggccaagc aggaggagct ggagcgggac ctggcccagc gctccgagga gcggcgcaag   6720

tggtttgagg ccacagacag caggacccca gaggtgcctg ctggtgaggg gccgcgccgg   6780

ggcctgggtg cccccctgac tgaggaccag caaaaccggc ttagtgagga gatcgagaag   6840

aagtggcagg agctggagaa gctgcccctg cgggagaata agcgggtgcc cctcactgcc   6900

ctgctcaacc aaagccgcgg agagcgccga gggcccccaa gtgacggcca cgaggcactg   6960

gagaaggagg ttcaggctct tcgggcccag ctggaggcgt ggcgtctcca aggggaggct   7020

cctcagagtg cactgagatc ccaggaggat ggccacatcc ccccgggcta catctcacag   7080

gaggcatgtg agcgcagcct ggcagagatg gagtcctcgc accagcaggt gatggaggag   7140

ctgcagcggc accacgagcg ggagctgcag cgcctgcagc aggagaagga gtggctcctg   7200

gctgaggaga cggcagccac ggcctcagcc attgaagcca tgaagaaggc ctaccaggaa   7260

gagctgagcc gagagctgag caaaacacgg agtctccagc agggcccgga tggcctccgg   7320

aagcagcacc agtcagatgt ggaggcactg aagcgagagc tgcaggtgct atcggagcag   7380

tactcgcaga agtgcctgga gattggggca ctcatgcggc aggctgagga gcgcgagcac   7440

acgctgcgcc gctgccagca ggagggccag gagctgctgc gccacaacca ggagctgcat   7500

ggccgcctgt cagaggagat agaccagctg cgcggcttca ttgcctcgca gggcatgggc   7560

aatggctgcg ggcgcagcaa cgagcggagt tcctgcgagc tagaggtgct gcttcgcgta   7620

aaagaaaacg aactccagta cctaaagaag gaggtgcagt gcctccggga cgagctccag   7680

atgatgcaga aggacaagcg cttcacctcg ggaaagtacc aggacgtcta tgtggagctg   7740

agccacatca agacacggtc tgagcgggag atcgagcagc tgaaggagca cctgcgtctt   7800

gccatggccg ccctccagga gaaggagtcg atgcgcaaca gcctggctga gtagaggtcc   7860

cgcccagctg cagaccctcc aggctggagg accagccgcc ctccttccct cctggatgga   7920

agtaaaaagc caagctttct ccccaccctc tgtgggccac acgtgcactt gcacccactg   7980

catatctgag cgcgcccctc gcactgggtc tcaccttgca ccttcttcag gattttatat   8040

gtgaagagat ttttatatag atttttttcc tttttttcca aaacacttta tactttaaaa   8100

aaaaaaaaaa aaagcaattc ctggtggctg tgtgcctcca accctggtcc ccctctgtct   8160

ccagccaccc tctgcttggg cttctgagct ggtggccctg gcccagaggt ctggcggagg   8220

cccaggcagc agccatggcg gggtgtctct acaggggaga ggcgggagcc tgccaccctc   8280

ttcctgccct acctcctact aacacttcct gccccatttg gacccgtacc atggggctca   8340

ggacagaggg agctagcagc tggcctccat ggccccacag cctccttcga ggctgtgctg   8400

ggtgcagaac cgccagagcc acccaaaagg tgtttctctt ctgctccctg aacctcttaa   8460

cttaataaaa cgttccagca gctctggtgt cctagatggc tggcagaaca ggaatggaga   8520

ttggggtttc ttgaagtggc ttccccactc acaccctacc cacaccccac ccttcctaaa   8580

gcagcggcct ctaggcttct gagggtgggg ctgaaaatcc aaggtctccc ttagtacaga   8640

ctgtgacgcc cccagtgtgg cttgcaggct agtggcagcg gaagcatgtg ggaaatagca   8700

agtccagtcc caccccaacc tactgaacca gcgtctgcat tttaacaggg tgccccagtg   8760

attcacgtga ccttcaaagt ctgaggagcc ctggagtagg gcccagggcc caggcctgag   8820

agagaggcct ggggctaaga ctagccctga ccatgacctt gggcaagtca cacccctcac   8880

tgagcctcag tttgcttctc catcaaatgg gtgtttttct ttcagtccca gtcctctcct   8940

gaggcttttc ccagaggtca tgcccagccc tgggcagggg tgagggcagg gttgtggctg   9000

ccaggcacag gtccagcggg ctgggagtcc tcaccatggc tggctgtgct gattatggtt   9060

gcatggggct gggaagaggt cccatttctg agccacagaa acaggccaca tccagtaggg   9120

gtcctggaag gctgtgagaa cccagaggag accctgaccc agcctgcagg tagaagactg   9180

cctttggagg cagctttgaa agatgactct tccagatgga agaatcagga agggccttcc   9240

cacgtggagg caccagcagg agcaaacgtc cctggtgtgt tcaggcaaag agccacagga   9300

gagtgacctc gtggagtggg aagagattgt ttcccattcc cttgccaggg attggttgag   9360

gaatggacaa ggcttgcagt tcacgcaagc cagtgaaatg cgaggggaag tcttgggagt   9420

ggggtggagg aggtcatctg ggaagggtgt ccttggtctt aaaaagaggc acaagaggcc   9480

gggcgcggtg gctcttgcct attatcctag cactttggga ggccaaggca gggggatcac   9540

ttgaggtcag gagttcgaga ccagcctggc caacatggtg aaaccccgtc tctactaaaa   9600

atacaaaaaa ttagccagac gtggtgccaa gcacctgtaa tcccagctac tcaggaggct   9660

gaggcaggag aatcacttga acccaggagg cagaagttgc agtgagccaa gatcgcgcca   9720

ctgcactcca gcctgtgtga caagggcgaa actccatctc aaaaaaaaag ggggagggtg   9780

gcgcaaggag aggacacctc tctcctggcc ctgtcgccat cttccctcat caatagctaa   9840

aaatggcaaa gaagaaagag ccaggacccc gtgccatcaa atcctccggc cttgtgctgc   9900

cctgtctcgg cactgcttgc cttaggagat caggagtgtt cctagccact gggagatggg   9960

atgcctgcca ctggcagctc tgccgtccat cctcaccatc ccaccgtccc cccaagacag  10020

ctctccatcc catcctctgc ctcccttcta gcctcaacct aactcagggc tcccccgtct  10080

cacacctggg ttgcaggaac atcctcttca ccaacccccc tcccatccct cctcagggct  10140

gcctagggca gctacaaaaa ccaggccagc ctctgaaagg tgctccacat ctcattaaaa  10200

accgtgaaat cgcactgccc cactatcaga atagctcaga ggagaaggtc tgccagtacc  10260

aagtgctggt ggggatacgg agaagagcag ctcccaggcg ctgctggtgc aaatgtgctt  10320

tgttgcaccc acggcaggaa actgaccagc ttctcatcaa gttaaatacg catctaccct  10380

atggcctagc atttccactc ttgcttacac atccaggaga aatgagtcct tacatgcaca  10440

aaaggatgag taccgtaata ctcacatcag caaataaaca atacagctgt gtgtcagtag  10500

tagaatgaat aaattgtggt cgattcatac gttagaatac agcaatttaa aaacaactgc  10560

tacacacaaa aatgttggtg aatctttcag acacaatgtt gagcaaaaat agccacagaa  10620

gagtgtaagg ctgtacgatt ttattt                                       10646


<210>  3618
<211>  1316
<212>  PRT
<213>  Homo sapiens

<400>  3618


Met Glu Glu Val Pro Gly Asp Ala Leu Cys Glu His Phe Glu Ala Asn 
1               5                   10                  15      


Ile Leu Thr Gln Asn Arg Cys Gln Asn Cys Phe His Pro Glu Glu Ala 
            20                  25                  30          


His Gly Ala Arg Tyr Gln Glu Leu Arg Ser Pro Ser Gly Ala Glu Val 
        35                  40                  45              


Pro Tyr Cys Asp Leu Pro Arg Cys Pro Pro Ala Pro Glu Asp Pro Leu 
    50                  55                  60                  


Ser Ala Ser Thr Ser Gly Cys Gln Ser Val Val Asp Pro Gly Leu Arg 
65                  70                  75                  80  


Pro Gly Pro Lys Arg Gly Pro Ser Pro Ser Ala Gly Leu Pro Glu Glu 
                85                  90                  95      


Gly Pro Thr Ala Ala Pro Arg Ser Arg Ser Arg Glu Leu Glu Ala Val 
            100                 105                 110         


Pro Tyr Leu Glu Gly Leu Thr Thr Ser Leu Cys Gly Ser Cys Asn Glu 
        115                 120                 125             


Asp Pro Gly Ser Asp Pro Thr Ser Ser Pro Asp Ser Ala Thr Pro Asp 
    130                 135                 140                 


Asp Thr Ser Asn Ser Ser Ser Val Asp Trp Asp Thr Val Glu Arg Gln 
145                 150                 155                 160 


Glu Glu Glu Ala Pro Ser Trp Asp Glu Leu Ala Val Met Ile Pro Arg 
                165                 170                 175     


Arg Pro Arg Glu Gly Pro Arg Ala Asp Ser Ser Gln Arg Ala Pro Ser 
            180                 185                 190         


Leu Leu Thr Arg Ser Pro Val Gly Gly Asp Ala Ala Gly Gln Lys Lys 
        195                 200                 205             


Glu Asp Thr Gly Gly Gly Gly Arg Ser Ala Gly Gln His Trp Ala Arg 
    210                 215                 220                 


Leu Arg Gly Glu Ser Gly Leu Ser Leu Glu Arg His Arg Ser Thr Leu 
225                 230                 235                 240 


Thr Gln Ala Ser Ser Met Thr Pro His Ser Gly Pro Arg Ser Thr Thr 
                245                 250                 255     


Ser Gln Ala Ser Pro Ala Gln Arg Asp Thr Ala Gln Ala Ala Ser Thr 
            260                 265                 270         


Arg Glu Ile Pro Arg Ala Ser Ser Pro His Arg Ile Thr Gln Arg Asp 
        275                 280                 285             


Thr Ser Arg Ala Ser Ser Thr Gln Gln Glu Ile Ser Arg Ala Ser Ser 
    290                 295                 300                 


Thr Gln Gln Glu Thr Ser Arg Ala Ser Ser Thr Gln Glu Asp Thr Pro 
305                 310                 315                 320 


Arg Ala Ser Ser Thr Gln Glu Asp Thr Pro Arg Ala Ser Ser Thr Gln 
                325                 330                 335     


Trp Asn Thr Pro Arg Ala Ser Ser Pro Ser Arg Ser Thr Gln Leu Asp 
            340                 345                 350         


Asn Pro Arg Thr Ser Ser Thr Gln Gln Asp Asn Pro Gln Thr Ser Phe 
        355                 360                 365             


Pro Thr Cys Thr Pro Gln Arg Glu Asn Pro Arg Thr Pro Cys Val Gln 
    370                 375                 380                 


Gln Asp Asp Pro Arg Ala Ser Ser Pro Asn Arg Thr Thr Gln Arg Glu 
385                 390                 395                 400 


Asn Ser Arg Thr Ser Cys Ala Gln Arg Asp Asn Pro Lys Ala Ser Arg 
                405                 410                 415     


Thr Ser Ser Pro Asn Arg Ala Thr Arg Asp Asn Pro Arg Thr Ser Cys 
            420                 425                 430         


Ala Gln Arg Asp Asn Pro Arg Ala Ser Ser Pro Ser Arg Ala Thr Arg 
        435                 440                 445             


Asp Asn Pro Thr Thr Ser Cys Ala Gln Arg Asp Asn Pro Arg Ala Ser 
    450                 455                 460                 


Arg Thr Ser Ser Pro Asn Arg Ala Thr Arg Asp Asn Pro Arg Thr Ser 
465                 470                 475                 480 


Cys Ala Gln Arg Asp Asn Pro Arg Ala Ser Ser Pro Ser Arg Ala Thr 
                485                 490                 495     


Arg Asp Asn Pro Thr Thr Ser Cys Ala Gln Arg Asp Asn Pro Arg Ala 
            500                 505                 510         


Ser Arg Thr Ser Ser Pro Asn Arg Ala Thr Arg Asp Asn Pro Arg Thr 
        515                 520                 525             


Ser Cys Ala Gln Arg Asp Asn Pro Arg Ala Ser Ser Pro Asn Arg Ala 
    530                 535                 540                 


Ala Arg Asp Asn Pro Thr Thr Ser Cys Ala Gln Arg Asp Asn Pro Arg 
545                 550                 555                 560 


Ala Ser Arg Thr Ser Ser Pro Asn Arg Ala Thr Arg Asp Asn Pro Arg 
                565                 570                 575     


Thr Ser Cys Ala Gln Arg Asp Asn Pro Arg Ala Ser Ser Pro Asn Arg 
            580                 585                 590         


Ala Thr Arg Asp Asn Pro Thr Thr Ser Cys Ala Gln Arg Asp Asn Pro 
        595                 600                 605             


Arg Ala Ser Arg Thr Ser Ser Pro Asn Arg Ala Thr Arg Asp Asn Pro 
    610                 615                 620                 


Arg Thr Ser Cys Ala Gln Arg Asp Asn Pro Arg Ala Ser Ser Pro Asn 
625                 630                 635                 640 


Arg Thr Thr Gln Gln Asp Ser Pro Arg Thr Ser Cys Ala Arg Arg Asp 
                645                 650                 655     


Asp Pro Arg Ala Ser Ser Pro Asn Arg Thr Ile Gln Gln Glu Asn Pro 
            660                 665                 670         


Arg Thr Ser Cys Ala Leu Arg Asp Asn Pro Arg Ala Ser Ser Pro Ser 
        675                 680                 685             


Arg Thr Ile Gln Gln Glu Asn Pro Arg Thr Ser Cys Ala Gln Arg Asp 
    690                 695                 700                 


Asp Pro Arg Ala Ser Ser Pro Asn Arg Thr Thr Gln Gln Glu Asn Pro 
705                 710                 715                 720 


Arg Thr Ser Cys Ala Arg Arg Asp Asn Pro Arg Ala Ser Ser Arg Asn 
                725                 730                 735     


Arg Thr Ile Gln Arg Asp Asn Pro Arg Thr Ser Cys Ala Gln Arg Asp 
            740                 745                 750         


Asn Pro Arg Ala Ser Ser Pro Asn Arg Thr Ile Gln Gln Glu Asn Leu 
        755                 760                 765             


Arg Thr Ser Cys Thr Arg Gln Asp Asn Pro Arg Thr Ser Ser Pro Asn 
    770                 775                 780                 


Arg Ala Thr Arg Asp Asn Pro Arg Thr Ser Cys Ala Gln Arg Asp Asn 
785                 790                 795                 800 


Leu Arg Ala Ser Ser Pro Ile Arg Ala Thr Gln Gln Asp Asn Pro Arg 
                805                 810                 815     


Thr Cys Ile Gln Gln Asn Ile Pro Arg Ser Ser Ser Thr Gln Gln Asp 
            820                 825                 830         


Asn Pro Lys Thr Ser Cys Thr Lys Arg Asp Asn Leu Arg Pro Thr Cys 
        835                 840                 845             


Thr Gln Arg Asp Arg Thr Gln Ser Phe Ser Phe Gln Arg Asp Asn Pro 
    850                 855                 860                 


Gly Thr Ser Ser Ser Gln Cys Cys Thr Gln Lys Glu Asn Leu Arg Pro 
865                 870                 875                 880 


Ser Ser Pro His Arg Ser Thr Gln Trp Asn Asn Pro Arg Asn Ser Ser 
                885                 890                 895     


Pro His Arg Thr Asn Lys Asp Ile Pro Trp Ala Ser Phe Pro Leu Arg 
            900                 905                 910         


Pro Thr Gln Ser Asp Gly Pro Arg Thr Ser Ser Pro Ser Arg Ser Lys 
        915                 920                 925             


Gln Ser Glu Val Pro Trp Ala Ser Ile Ala Leu Arg Pro Thr Gln Gly 
    930                 935                 940                 


Asp Arg Pro Gln Thr Ser Ser Pro Ser Arg Pro Ala Gln His Asp Pro 
945                 950                 955                 960 


Pro Gln Ser Ser Phe Gly Pro Thr Gln Tyr Asn Leu Pro Ser Arg Ala 
                965                 970                 975     


Thr Ser Ser Ser His Asn Pro Gly His Gln Ser Thr Ser Arg Thr Ser 
            980                 985                 990         


Ser Pro Val Tyr Pro Ala Ala Tyr  Gly Ala Pro Leu Thr  Ser Pro Glu 
        995                 1000                 1005             


Pro Ser  Gln Pro Pro Cys Ala  Val Cys Ile Gly His  Arg Asp Ala 
    1010                 1015                 1020             


Pro Arg  Ala Ser Ser Pro Pro  Arg Tyr Leu Gln His  Asp Pro Phe 
    1025                 1030                 1035             


Pro Phe  Phe Pro Glu Pro Arg  Ala Pro Glu Ser Glu  Pro Pro His 
    1040                 1045                 1050             


His Glu  Pro Pro Tyr Ile Pro  Pro Ala Val Cys Ile  Gly His Arg 
    1055                 1060                 1065             


Asp Ala  Pro Arg Ala Ser Ser  Pro Pro Arg His Thr  Gln Phe Asp 
    1070                 1075                 1080             


Pro Phe  Pro Phe Leu Pro Asp  Thr Ser Asp Ala Glu  His Gln Cys 
    1085                 1090                 1095             


Gln Ser  Pro Gln His Glu Pro  Leu Gln Leu Pro Ala  Pro Val Cys 
    1100                 1105                 1110             


Ile Gly  Tyr Arg Asp Ala Pro  Arg Ala Ser Ser Pro  Pro Arg Gln 
    1115                 1120                 1125             


Ala Pro  Glu Pro Ser Leu Leu  Phe Gln Asp Leu Pro  Arg Ala Ser 
    1130                 1135                 1140             


Thr Glu  Ser Leu Val Pro Ser  Met Asp Ser Leu His  Glu Cys Pro 
    1145                 1150                 1155             


His Ile  Pro Thr Pro Val Cys  Ile Gly His Arg Asp  Ala Pro Ser 
    1160                 1165                 1170             


Phe Ser  Ser Pro Pro Arg Gln  Ala Pro Glu Pro Ser  Leu Phe Phe 
    1175                 1180                 1185             


Gln Asp  Pro Pro Gly Thr Ser  Met Glu Ser Leu Ala  Pro Ser Thr 
    1190                 1195                 1200             


Asp Ser  Leu His Gly Ser Pro  Val Leu Ile Pro Gln  Val Cys Ile 
    1205                 1210                 1215             


Gly His  Arg Asp Ala Pro Arg  Ala Ser Ser Pro Pro  Arg His Pro 
    1220                 1225                 1230             


Pro Ser  Asp Leu Ala Phe Leu  Ala Pro Ser Pro Ser  Pro Gly Ser 
    1235                 1240                 1245             


Ser Gly  Gly Ser Arg Gly Ser  Ala Pro Pro Gly Glu  Thr Arg His 
    1250                 1255                 1260             


Asn Leu  Glu Arg Glu Glu Tyr  Thr Val Leu Ala Asp  Leu Pro Pro 
    1265                 1270                 1275             


Pro Arg  Arg Leu Ala Gln Arg  Gln Pro Gly Pro Gln  Ala Gln Cys 
    1280                 1285                 1290             


Ser Ser  Gly Gly Arg Thr His  Ser Pro Gly Arg Ala  Glu Val Glu 
    1295                 1300                 1305             


Arg Leu  Phe Gly Gln Glu Arg  Arg 
    1310                 1315     

<210>  3619
<211>  719
<212>  DNA
<213>  Homo sapiens

<400>  3619
gagtacgcta cacccggaag tgtcttcagg gagaggaagc cggcggcctc actgctatgg     60

gccgcaacaa gaagaagaag cgagatggtg acgaccggcg gccgaggctc gttcttagct    120

tcgacgagga gaagaggcgg gagtacctga caggcttcca caagcggaag gtcgagcgaa    180

agaaggcagc cattgaggag attaagcagc ggctgaaaga ggagcagagg aagcttcggg    240

aggagcgcca ccaggaatac ttgaagatgc tggcagagag agaagaggct ctggaacgaa    300

gcggtgcccc agtctaggct gcggggacct gtccttgctc agcttggctg tccctgtagc    360

ccagcctgca cctaggtaat gactgcacag ctcaaggttg ggaagccagg acctctctgg    420

cctggggcca gctgcctttg cctggggtca gctgcctttg cctggggttt gaattcccga    480

aggagcaggc agctgagagc aggcctcccc caggaagagc cttcagagcc acgtgggggc    540

atcttcccaa atgtgcaccc cacctggcac tcatcagatt tgtgcgcttg tgatttgttt    600

gtccttgata ccacgcacaa gggcaggttt ttggggtggt ggaaatggcc agggcccatg    660

ggtctgtctc cagcagttag ccctgtggct gcaataaagt acagttctcc ctgtgttaa     719


<210>  3620
<211>  86
<212>  PRT
<213>  Homo sapiens

<400>  3620


Met Gly Arg Asn Lys Lys Lys Lys Arg Asp Gly Asp Asp Arg Arg Pro 
1               5                   10                  15      


Arg Leu Val Leu Ser Phe Asp Glu Glu Lys Arg Arg Glu Tyr Leu Thr 
            20                  25                  30          


Gly Phe His Lys Arg Lys Val Glu Arg Lys Lys Ala Ala Ile Glu Glu 
        35                  40                  45              


Ile Lys Gln Arg Leu Lys Glu Glu Gln Arg Lys Leu Arg Glu Glu Arg 
    50                  55                  60                  


His Gln Glu Tyr Leu Lys Met Leu Ala Glu Arg Glu Glu Ala Leu Glu 
65                  70                  75                  80  


Arg Ser Gly Ala Pro Val 
                85      

<210>  3621
<211>  3219
<212>  DNA
<213>  Homo sapiens

<400>  3621
gagtacgcta cacccggaag tgtcttcagg gagaggaagc cggcggcctc actgctatgg     60

gccgcaacaa gaagaagaag cgagatggtg acgaccggcg gccgaggctc gttcttagct    120

tcgacgagga gaagaggcgg gagtacctga caggcttcca caagcggaag gtcgagcgaa    180

agaaggcagc cattgaggag attaagcagc ggctgaaaga ggagcagagg aagcttcggg    240

aggagcgcca ccaggaatac ttgaagatgc tggcagagag agaagaggct ctggaggagg    300

cagatgagct ggaccggttg gtgacagcaa agacggagtc ggtgcagtat gaccacccca    360

accacacagt caccgtgacc accatcagtg acctggacct ctcgggggcc cggctgctcg    420

ggctgacccc acctgaggga ggggctggag acaggtctga ggaggaggcg tcatccacgg    480

agaaaccaac caaagccttg cccaggaagt ccagagaccc cctgctctct cagcggtgag    540

tcttggcctg ctgcctcccc ggtcccaccc ctcctggctg gcagtagtga cctggccctt    600

agggtggtgt ggagcaggtg tagggcccgg agcagccctc tgcctgtcca gtgatcctct    660

gcctctcctc attgccccgt cctgtcccac ccacccctga tagtgtctga cctccagtgc    720

ttttcgtgcc tgggtgaagg gcctgtgtct ctgagctgag ttgctggcag gcactctgga    780

ggtagagcag gccaactctg gcatgaactt ggcggtcctg gcattcgcaa cctgtcctga    840

catcccctcc gtgagccagg tggtgagtca ccccacaatg caatcttaaa ctgaggcttt    900

ctgccctccc ctaggatctc ctccctcaca gcatcactac atgcacacag ccgcaaaaag    960

gtcaagagga aacatccccg acgggcccag gactccaaaa agcccccaag ggcccctcgt   1020

accagcaagg cccagcgccg ccgtctcaca ggcaaagcac ggcacagcgg ggagtgagac   1080

cgagaacgaa gcggtgcccc agtctaggct gcggggacct gtccttgctc agcttggctg   1140

tccctgtagc ccagcctgca cctaggtaat gactgcacag ctcaaggttg ggaagccagg   1200

acctctctgg cctggggcca gctgcctttg cctggggtca gctgcctttg cctggggttt   1260

gaattcccga aggagcaggc agctgagagc aggcctcccc caggaagagc cttcagagcc   1320

acgtgggggc atcttcccaa atgtgcaccc cacctggcac tcatcagatt tgtgcgcttg   1380

tgatttgttt gtccttgata ccacgcacaa gggcaggttt ttggggtggt ggaaatggcc   1440

agggcccatg ggtctgtctc cagcagttag ccctgtggct gcaataaagt acagttctcc   1500

ctgtgttaag atcctaacca gggttaagga tcagtgtgtc cgttgctaga atccagagcc   1560

cacctgctgc tctgaaaagc aggctcctga ggccagtggg ggagcagtgc cccccatgcc   1620

cttcaccgag gagcctctgt gcctgtccct tgtcctcggc cccaggagtc tcctcaactg   1680

acactgaagt ggtggaagca gttgagtgcc aggtcatccc ccatcaccac actggggcag   1740

cgtccccagg cttccagcag ctcccaggtg ggtcccaacg tggaaggatt aattaattct   1800

ttctaaagca gttgcagccg ggcttggtgg ctcacgcctg taatcccagc actttgggag   1860

gcccaggcgg gcagatcact taaggtcggg agctcgagac cagcctggcc aacatggtga   1920

aaccctgtct ctactaaaaa tgcaaaaatt agccaggtgt ggtggcacac gcgtgtaatc   1980

ccagctactt gggaggctga ggtggaagaa tcacttgaac cctggaggcg gaggctgcag   2040

tgagccgaga tcacgccatt gcactccagc ctgggcaacg ttgtgacctt gtctcaaaaa   2100

aaaactaaaa aataaagcag ttgcatcttg actcgtacaa aagtagcccc caccagagta   2160

gaccctgcgg gtgccagcta gaactccaca aggggccatg tcttcacact ccttccagat   2220

ggatgagttg atggaaaccc tgtcccttcc ttgtcccagc ttgtcagtcc tgggcaggag   2280

agaatttcag gttgtgcctt ggttagagga gctgtgttgg gtcctaaaca ctaggaccac   2340

aaaggggagt gaactgtgtt cccagggctt gctgacgccc gtggactatg gagtcaggat   2400

gacaggacag tgcggtgagg ggcatctgcg acaggactgc gggctctacc cgccctgatg   2460

tgggagctcc tggagtgggg gtgagcagtg agccagggtc tgcagggctg tcctctctcc   2520

acagccaaca gccaggcctt acagtggggc aggcttagtg actgtgcctc agttatgctg   2580

tacctgggag tgggcaggcc ctctcccatg tcaccatcaa aacccactga tgaaggctgg   2640

tgggagtctg agggctgcac ccgggtatgg tgagttcccc tcagggattg tgctgagcgc   2700

cttggcctgg cttcttggct ccgcccacct gctctccctg ccaccaagtt gtcttccccg   2760

ggtggcatgt gccacttggc tgcctcgtgc ctgggcacag tggtgcctat tatgggccct   2820

ccaggtggct ctggtgctca gcctgctgtg agcaggaaca gctgagtccc aggggttctt   2880

gcacacagca gggctcgggt ttgaatccag gctctgctgc ttggtcgctg catgagcttc   2940

tgctgtgctg acctctctgg tttgtctcgt catgtgtaag gtgacaccag atacctacct   3000

cttagggctg ccccgagact aaaataagac catgtgcatg aaccacttac caaagtgcct   3060

gttgctctcc aggtgtgcct accgcatgtt gccgctgctg tttctgctgg gacgtctgac   3120

tccagttcct tctcccctct ccagtgacaa ggtcatttac aacttacatt tacaatttat   3180

agtgtttacc agtattaaat tctcagccac tcctttcca                          3219


<210>  3622
<211>  160
<212>  PRT
<213>  Homo sapiens

<400>  3622


Met Gly Arg Asn Lys Lys Lys Lys Arg Asp Gly Asp Asp Arg Arg Pro 
1               5                   10                  15      


Arg Leu Val Leu Ser Phe Asp Glu Glu Lys Arg Arg Glu Tyr Leu Thr 
            20                  25                  30          


Gly Phe His Lys Arg Lys Val Glu Arg Lys Lys Ala Ala Ile Glu Glu 
        35                  40                  45              


Ile Lys Gln Arg Leu Lys Glu Glu Gln Arg Lys Leu Arg Glu Glu Arg 
    50                  55                  60                  


His Gln Glu Tyr Leu Lys Met Leu Ala Glu Arg Glu Glu Ala Leu Glu 
65                  70                  75                  80  


Glu Ala Asp Glu Leu Asp Arg Leu Val Thr Ala Lys Thr Glu Ser Val 
                85                  90                  95      


Gln Tyr Asp His Pro Asn His Thr Val Thr Val Thr Thr Ile Ser Asp 
            100                 105                 110         


Leu Asp Leu Ser Gly Ala Arg Leu Leu Gly Leu Thr Pro Pro Glu Gly 
        115                 120                 125             


Gly Ala Gly Asp Arg Ser Glu Glu Glu Ala Ser Ser Thr Glu Lys Pro 
    130                 135                 140                 


Thr Lys Ala Leu Pro Arg Lys Ser Arg Asp Pro Leu Leu Ser Gln Arg 
145                 150                 155                 160 

<210>  3623
<211>  2840
<212>  DNA
<213>  Homo sapiens

<400>  3623
gagtacgcta cacccggaag tgtcttcagg gagaggaagc cggcggcctc actgctatgg     60

gccgcaacaa gaagaagaag cgagatggtg acgaccggcg gccgaggctc gttcttagct    120

tcgacgagga gaagaggcgg gagtacctga caggcttcca caagcggaag gtcgagcgaa    180

agaaggcagc cattgaggag attaagcagc ggctgaaaga ggagcagagg aagcttcggg    240

aggagcgcca ccaggaatac ttgaagatgc tggcagagag agaagaggct ctggaggagg    300

cagatgagct ggaccggttg gtgacagcaa agacggagtc ggtgcagtat gaccacccca    360

accacacagt caccgtgacc accatcagtg acctggacct ctcgggggcc cggctgctcg    420

ggctgacccc acctgaggga ggggctggag acaggtctga ggaggaggcg tcatccacgg    480

agaaaccaac caaagccttg cccaggaagt ccagagaccc cctgctctct cagcggatct    540

cctccctcac agcatcacta catgcacaca gccgcaaaaa ggtcaagagg aaacatcccc    600

gacgggccca ggactccaaa aagcccccaa gggcccctcg taccagcaag gcccagcgcc    660

gccgtctcac aggcaaagca cggcacagcg gggagtgaga ccgagaacga agcggtgccc    720

cagtctaggc tgcggggacc tgtccttgct cagcttggct gtccctgtag cccagcctgc    780

acctaggtaa tgactgcaca gctcaaggtt gggaagccag gacctctctg gcctggggcc    840

agctgccttt gcctggggtc agctgccttt gcctggggtt tgaattcccg aaggagcagg    900

cagctgagag caggcctccc ccaggaagag ccttcagagc cacgtggggg catcttccca    960

aatgtgcacc ccacctggca ctcatcagat ttgtgcgctt gtgatttgtt tgtccttgat   1020

accacgcaca agggcaggtt tttggggtgg tggaaatggc cagggcccat gggtctgtct   1080

ccagcagtta gccctgtggc tgcaataaag tacagttctc cctgtgttaa gatcctaacc   1140

agggttaagg atcagtgtgt ccgttgctag aatccagagc ccacctgctg ctctgaaaag   1200

caggctcctg aggccagtgg gggagcagtg ccccccatgc ccttcaccga ggagcctctg   1260

tgcctgtccc ttgtcctcgg ccccaggagt ctcctcaact gacactgaag tggtggaagc   1320

agttgagtgc caggtcatcc cccatcacca cactggggca gcgtccccag gcttccagca   1380

gctcccaggt gggtcccaac gtggaaggat taattaattc tttctaaagc agttgcagcc   1440

gggcttggtg gctcacgcct gtaatcccag cactttggga ggcccaggcg ggcagatcac   1500

ttaaggtcgg gagctcgaga ccagcctggc caacatggtg aaaccctgtc tctactaaaa   1560

atgcaaaaat tagccaggtg tggtggcaca cgcgtgtaat cccagctact tgggaggctg   1620

aggtggaaga atcacttgaa ccctggaggc ggaggctgca gtgagccgag atcacgccat   1680

tgcactccag cctgggcaac gttgtgacct tgtctcaaaa aaaaactaaa aaataaagca   1740

gttgcatctt gactcgtaca aaagtagccc ccaccagagt agaccctgcg ggtgccagct   1800

agaactccac aaggggccat gtcttcacac tccttccaga tggatgagtt gatggaaacc   1860

ctgtcccttc cttgtcccag cttgtcagtc ctgggcagga gagaatttca ggttgtgcct   1920

tggttagagg agctgtgttg ggtcctaaac actaggacca caaaggggag tgaactgtgt   1980

tcccagggct tgctgacgcc cgtggactat ggagtcagga tgacaggaca gtgcggtgag   2040

gggcatctgc gacaggactg cgggctctac ccgccctgat gtgggagctc ctggagtggg   2100

ggtgagcagt gagccagggt ctgcagggct gtcctctctc cacagccaac agccaggcct   2160

tacagtgggg caggcttagt gactgtgcct cagttatgct gtacctggga gtgggcaggc   2220

cctctcccat gtcaccatca aaacccactg atgaaggctg gtgggagtct gagggctgca   2280

cccgggtatg gtgagttccc ctcagggatt gtgctgagcg ccttggcctg gcttcttggc   2340

tccgcccacc tgctctccct gccaccaagt tgtcttcccc gggtggcatg tgccacttgg   2400

ctgcctcgtg cctgggcaca gtggtgccta ttatgggccc tccaggtggc tctggtgctc   2460

agcctgctgt gagcaggaac agctgagtcc caggggttct tgcacacagc agggctcggg   2520

tttgaatcca ggctctgctg cttggtcgct gcatgagctt ctgctgtgct gacctctctg   2580

gtttgtctcg tcatgtgtaa ggtgacacca gatacctacc tcttagggct gccccgagac   2640

taaaataaga ccatgtgcat gaaccactta ccaaagtgcc tgttgctctc caggtgtgcc   2700

taccgcatgt tgccgctgct gtttctgctg ggacgtctga ctccagttcc ttctcccctc   2760

tccagtgaca aggtcattta caacttacat ttacaattta tagtgtttac cagtattaaa   2820

ttctcagcca ctcctttcca                                               2840


<210>  3624
<211>  213
<212>  PRT
<213>  Homo sapiens

<400>  3624


Met Gly Arg Asn Lys Lys Lys Lys Arg Asp Gly Asp Asp Arg Arg Pro 
1               5                   10                  15      


Arg Leu Val Leu Ser Phe Asp Glu Glu Lys Arg Arg Glu Tyr Leu Thr 
            20                  25                  30          


Gly Phe His Lys Arg Lys Val Glu Arg Lys Lys Ala Ala Ile Glu Glu 
        35                  40                  45              


Ile Lys Gln Arg Leu Lys Glu Glu Gln Arg Lys Leu Arg Glu Glu Arg 
    50                  55                  60                  


His Gln Glu Tyr Leu Lys Met Leu Ala Glu Arg Glu Glu Ala Leu Glu 
65                  70                  75                  80  


Glu Ala Asp Glu Leu Asp Arg Leu Val Thr Ala Lys Thr Glu Ser Val 
                85                  90                  95      


Gln Tyr Asp His Pro Asn His Thr Val Thr Val Thr Thr Ile Ser Asp 
            100                 105                 110         


Leu Asp Leu Ser Gly Ala Arg Leu Leu Gly Leu Thr Pro Pro Glu Gly 
        115                 120                 125             


Gly Ala Gly Asp Arg Ser Glu Glu Glu Ala Ser Ser Thr Glu Lys Pro 
    130                 135                 140                 


Thr Lys Ala Leu Pro Arg Lys Ser Arg Asp Pro Leu Leu Ser Gln Arg 
145                 150                 155                 160 


Ile Ser Ser Leu Thr Ala Ser Leu His Ala His Ser Arg Lys Lys Val 
                165                 170                 175     


Lys Arg Lys His Pro Arg Arg Ala Gln Asp Ser Lys Lys Pro Pro Arg 
            180                 185                 190         


Ala Pro Arg Thr Ser Lys Ala Gln Arg Arg Arg Leu Thr Gly Lys Ala 
        195                 200                 205             


Arg His Ser Gly Glu 
    210             

<210>  3625
<211>  460
<212>  DNA
<213>  Homo sapiens

<400>  3625
gctacacccg gaagtgtctt cagggagagg aagccggcgg cctcactgct atgggccgca     60

acaagaagaa gaagcgagat ggtgacgacc ggcggccgag gctcgttctt agcttcgacg    120

aggagaagag gcgggagtac ctgacaggct tccacaagcg gaaggtcgag cgaaagaagg    180

cagccattga ggagattaag cagcggctga aagaggagca gaggaagctt cgggaggagg    240

tacgcagggg gaaggtggga gggaggtctt tgattcttag ggcacttgca gccttggatt    300

tccctaatag aggcagctgc tggcatgggg cgatgtgtgt gtgggcagga ctggggaata    360

gtttatacag gtggagactc tgtgggcccg ggtctgggag tgatggaaga tggagtctcc    420

tcctgatctt gcagtatgga tcatggtctc cctcaccctg                          460


<210>  3626
<211>  135
<212>  PRT
<213>  Homo sapiens

<400>  3626


Met Gly Arg Asn Lys Lys Lys Lys Arg Asp Gly Asp Asp Arg Arg Pro 
1               5                   10                  15      


Arg Leu Val Leu Ser Phe Asp Glu Glu Lys Arg Arg Glu Tyr Leu Thr 
            20                  25                  30          


Gly Phe His Lys Arg Lys Val Glu Arg Lys Lys Ala Ala Ile Glu Glu 
        35                  40                  45              


Ile Lys Gln Arg Leu Lys Glu Glu Gln Arg Lys Leu Arg Glu Glu Val 
    50                  55                  60                  


Arg Arg Gly Lys Val Gly Gly Arg Ser Leu Ile Leu Arg Ala Leu Ala 
65                  70                  75                  80  


Ala Leu Asp Phe Pro Asn Arg Gly Ser Cys Trp His Gly Ala Met Cys 
                85                  90                  95      


Val Trp Ala Gly Leu Gly Asn Ser Leu Tyr Arg Trp Arg Leu Cys Gly 
            100                 105                 110         


Pro Gly Ser Gly Ser Asp Gly Arg Trp Ser Leu Leu Leu Ile Leu Gln 
        115                 120                 125             


Tyr Gly Ser Trp Ser Pro Ser 
    130                 135 

<210>  3627
<211>  323
<212>  DNA
<213>  Homo sapiens

<400>  3627
cctgaggcca gtgggggagc agtgcccccc atgcccttca ccgaggagcc tctgtgcctg     60

tcccttgtcc tcggccccag gagtctcctc aactgacact gaagtggtgg aagcagttga    120

gtgccaggtc atcccccatc accacactgg ggcagcgtcc ccaggcttcc agcagctccc    180

aggtgtgcct accgcatgtt gccgctgctg tttctgctgg gacgtctgac tccagttcct    240

tctcccctct ccagtgacaa ggtcatttac aacttacatt tacaatttat agtgtttacc    300

agtattaaat tctcagccac tcc                                            323


<210>  3628
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  3628


Met Leu Pro Leu Leu Phe Leu Leu Gly Arg Leu Thr Pro Val Pro Ser 
1               5                   10                  15      


Pro Leu Ser Ser Asp Lys Val Ile Tyr Asn Leu His Leu Gln Phe Ile 
            20                  25                  30          


Val Phe Thr Ser Ile Lys Phe Ser Ala 
        35                  40      

<210>  3629
<211>  3029
<212>  DNA
<213>  Homo sapiens

<400>  3629
cttccacctc ccgagcatcg ctctgattca ttgttaaaat aaagaggcca tgaccctggc     60

actcccaccc cggcagcccc tgtgcgtgga aacccagcca aggtctgatg atggaggagc    120

cttggccctg gctgtcccag gggaggaggt gaaattcctc agctctccac caagattggc    180

cacaaaagcc tgatcccctg gaacacagca ggcctcacat agacggtcag ccattggatc    240

ataggaactg ccctggcctg actcacccaa tatggaggag gtgcctgggg atgccctgtg    300

tgaacacttt gaggccaaca tacttaccca gaaccgctgt caaaactgct tccaccctga    360

ggaggcccat ggagcaagat accaggagct caggagccct tcaggtgctg aggtgcccta    420

ctgcgacctg cctcgatgtc cacctgcccc tgaggaccca ctcagcgcct caacctccgg    480

ctgccagtct gtggtggacc caggcctcag gccagggccc aagaggggcc catccccctc    540

agcagggctc ccagaagagg gtcccacagc tgcccccagg agcaggagcc gggagcttga    600

ggcagtaccc tatctggagg gcctgaccac ttccttgtgt ggcagctgca acgaggaccc    660

cggctctgac cccacctcca gccctgactc cgccacccct gatgatacca gcaactcgtc    720

ctctgtggac tgggacactg ttgagaggca ggaggaggag gcccccagct gggacgagct    780

cgcagtgatg atcccgagga ggcctcggga ggggccgaga gctgacagct cccaaagggc    840

tccgtctctc ctcaccaggt cccctgtggg aggagatgct gcaggccaga aaaaggagga    900

caccggcggt gggggccgga gcgcaggaca gcactgggca aggctccggg gagaaagcgg    960

gttgtccctg gagcggcacc ggtcaacact gacccaggct tcctccatga caccacacag   1020

tggacctcga agcaccacgt ctcaggcttc tcctgcccaa agggacactg ctcaggctgc   1080

ctctacacgt gaaatcccca gagcctcctc tccccatcga atcacccaaa gggacacctc   1140

cagggcctca tccacccaac aggaaatctc cagggcctca tccacccaac aggaaacctc   1200

cagggcctca tccacccaag aggacacccc tagggcctca tccacccaag aggacacccc   1260

cagggcctca tctacacagt ggaacacccc cagagcttcc tctccctcac gaagcaccca   1320

actggataac cccagaacct cttctaccca gcaggacaac ccccaaactt cttttcctac   1380

ttgtactccc cagcgggaaa accccaggac accctgtgtc cagcaggacg atcccagagc   1440

ctcctctccc aacagaacca ctcaacgaga gaattccaga acatcctgtg cccagcggga   1500

caatcccaaa gcctccagaa cctcctctcc caatagagcc acacgagaca accccagaac   1560

atcctgcgcc cagcgggaca atcccagagc ctcctctccc agtagagcta cacgagacaa   1620

ccccacaaca tcctgtgccc agcgggacaa tcccagagcc tccagaacct cctctcccaa   1680

tagagccaca cgagacaacc ccagaacatc ctgtgcccag cgggacaatc ccagagcctc   1740

ctctcccagt agagctacac gagacaaccc cacaacatcc tgtgcccagc gggacaatcc   1800

cagagcctcc agaacctcct ctcccaatag agccacacga gacaacccca gaacatcctg   1860

cgcccagcgg gacaatccca gagcctcctc tcccaataga gctgcacgag acaaccccac   1920

aacatcctgt gcccagcggg acaatcccag agcctccaga acctcctctc ccaatagagc   1980

cacacgagac aaccccagaa catcctgtgc ccagcgggac aatcccagag cctcctctcc   2040

caatagagct acacgagaca accccacaac atcctgtgcc cagcgggaca atcccagagc   2100

ctccagaacc tcctctccca atagagccac acgagataac cccagaacat cctgtgccca   2160

gcgggacaat cccagagcct cctctcccaa cagaaccacc caacaagaca gccccagaac   2220

atcctgtgcc cgacgggacg atcccagagc ctcctctcct aacagaacca tccaacaaga   2280

gaaccccaga acatcctgtg ccctacggga caatcccaga gcctcctctc ccagcagaac   2340

catccaacaa gagaacccca gaacatcctg tgcccaacgg gacgatccca gagcctcctc   2400

tcctaacaga accacccacc caccacacac acacacacac acacacacac acacacagac   2460

acacagacac atacgcacac acgtgcacac atgtacacac ggatacacac acacacacac   2520

acactgcata tctgagcgcg cccctcgcac tgggtctcac cttgcacctt cttcaggatt   2580

ttatatgtga agagattttt atatagattt ttttcctttt tttccaaaac actttatact   2640

ttaaaaaaaa aaaaaaaaag caattcctgg tggctgtgtg cctccaaccc tggtccccct   2700

ctgtctccag ccaccctctg cttgggcttc tgagctggtg gccctggccc agaggtctgg   2760

cggaggccca ggcagcagcc atggcggggt gtctctacag gggagaggcg ggagcctgcc   2820

accctcttcc tgccctacct cctactaaca cttcctgccc catttggacc cgtaccatgg   2880

ggctcaggac agagggagct agcagctggc ctccatggcc ccacagcctc cttcgaggct   2940

gtgctgggtg cagaaccgcc agagccaccc aaaaggtgtt tctcttctgc tccctgaacc   3000

tcttaactta ataaaacgtt ccagcagct                                     3029


<210>  3630
<211>  772
<212>  PRT
<213>  Homo sapiens

<400>  3630


Met Glu Glu Val Pro Gly Asp Ala Leu Cys Glu His Phe Glu Ala Asn 
1               5                   10                  15      


Ile Leu Thr Gln Asn Arg Cys Gln Asn Cys Phe His Pro Glu Glu Ala 
            20                  25                  30          


His Gly Ala Arg Tyr Gln Glu Leu Arg Ser Pro Ser Gly Ala Glu Val 
        35                  40                  45              


Pro Tyr Cys Asp Leu Pro Arg Cys Pro Pro Ala Pro Glu Asp Pro Leu 
    50                  55                  60                  


Ser Ala Ser Thr Ser Gly Cys Gln Ser Val Val Asp Pro Gly Leu Arg 
65                  70                  75                  80  


Pro Gly Pro Lys Arg Gly Pro Ser Pro Ser Ala Gly Leu Pro Glu Glu 
                85                  90                  95      


Gly Pro Thr Ala Ala Pro Arg Ser Arg Ser Arg Glu Leu Glu Ala Val 
            100                 105                 110         


Pro Tyr Leu Glu Gly Leu Thr Thr Ser Leu Cys Gly Ser Cys Asn Glu 
        115                 120                 125             


Asp Pro Gly Ser Asp Pro Thr Ser Ser Pro Asp Ser Ala Thr Pro Asp 
    130                 135                 140                 


Asp Thr Ser Asn Ser Ser Ser Val Asp Trp Asp Thr Val Glu Arg Gln 
145                 150                 155                 160 


Glu Glu Glu Ala Pro Ser Trp Asp Glu Leu Ala Val Met Ile Pro Arg 
                165                 170                 175     


Arg Pro Arg Glu Gly Pro Arg Ala Asp Ser Ser Gln Arg Ala Pro Ser 
            180                 185                 190         


Leu Leu Thr Arg Ser Pro Val Gly Gly Asp Ala Ala Gly Gln Lys Lys 
        195                 200                 205             


Glu Asp Thr Gly Gly Gly Gly Arg Ser Ala Gly Gln His Trp Ala Arg 
    210                 215                 220                 


Leu Arg Gly Glu Ser Gly Leu Ser Leu Glu Arg His Arg Ser Thr Leu 
225                 230                 235                 240 


Thr Gln Ala Ser Ser Met Thr Pro His Ser Gly Pro Arg Ser Thr Thr 
                245                 250                 255     


Ser Gln Ala Ser Pro Ala Gln Arg Asp Thr Ala Gln Ala Ala Ser Thr 
            260                 265                 270         


Arg Glu Ile Pro Arg Ala Ser Ser Pro His Arg Ile Thr Gln Arg Asp 
        275                 280                 285             


Thr Ser Arg Ala Ser Ser Thr Gln Gln Glu Ile Ser Arg Ala Ser Ser 
    290                 295                 300                 


Thr Gln Gln Glu Thr Ser Arg Ala Ser Ser Thr Gln Glu Asp Thr Pro 
305                 310                 315                 320 


Arg Ala Ser Ser Thr Gln Glu Asp Thr Pro Arg Ala Ser Ser Thr Gln 
                325                 330                 335     


Trp Asn Thr Pro Arg Ala Ser Ser Pro Ser Arg Ser Thr Gln Leu Asp 
            340                 345                 350         


Asn Pro Arg Thr Ser Ser Thr Gln Gln Asp Asn Pro Gln Thr Ser Phe 
        355                 360                 365             


Pro Thr Cys Thr Pro Gln Arg Glu Asn Pro Arg Thr Pro Cys Val Gln 
    370                 375                 380                 


Gln Asp Asp Pro Arg Ala Ser Ser Pro Asn Arg Thr Thr Gln Arg Glu 
385                 390                 395                 400 


Asn Ser Arg Thr Ser Cys Ala Gln Arg Asp Asn Pro Lys Ala Ser Arg 
                405                 410                 415     


Thr Ser Ser Pro Asn Arg Ala Thr Arg Asp Asn Pro Arg Thr Ser Cys 
            420                 425                 430         


Ala Gln Arg Asp Asn Pro Arg Ala Ser Ser Pro Ser Arg Ala Thr Arg 
        435                 440                 445             


Asp Asn Pro Thr Thr Ser Cys Ala Gln Arg Asp Asn Pro Arg Ala Ser 
    450                 455                 460                 


Arg Thr Ser Ser Pro Asn Arg Ala Thr Arg Asp Asn Pro Arg Thr Ser 
465                 470                 475                 480 


Cys Ala Gln Arg Asp Asn Pro Arg Ala Ser Ser Pro Ser Arg Ala Thr 
                485                 490                 495     


Arg Asp Asn Pro Thr Thr Ser Cys Ala Gln Arg Asp Asn Pro Arg Ala 
            500                 505                 510         


Ser Arg Thr Ser Ser Pro Asn Arg Ala Thr Arg Asp Asn Pro Arg Thr 
        515                 520                 525             


Ser Cys Ala Gln Arg Asp Asn Pro Arg Ala Ser Ser Pro Asn Arg Ala 
    530                 535                 540                 


Ala Arg Asp Asn Pro Thr Thr Ser Cys Ala Gln Arg Asp Asn Pro Arg 
545                 550                 555                 560 


Ala Ser Arg Thr Ser Ser Pro Asn Arg Ala Thr Arg Asp Asn Pro Arg 
                565                 570                 575     


Thr Ser Cys Ala Gln Arg Asp Asn Pro Arg Ala Ser Ser Pro Asn Arg 
            580                 585                 590         


Ala Thr Arg Asp Asn Pro Thr Thr Ser Cys Ala Gln Arg Asp Asn Pro 
        595                 600                 605             


Arg Ala Ser Arg Thr Ser Ser Pro Asn Arg Ala Thr Arg Asp Asn Pro 
    610                 615                 620                 


Arg Thr Ser Cys Ala Gln Arg Asp Asn Pro Arg Ala Ser Ser Pro Asn 
625                 630                 635                 640 


Arg Thr Thr Gln Gln Asp Ser Pro Arg Thr Ser Cys Ala Arg Arg Asp 
                645                 650                 655     


Asp Pro Arg Ala Ser Ser Pro Asn Arg Thr Ile Gln Gln Glu Asn Pro 
            660                 665                 670         


Arg Thr Ser Cys Ala Leu Arg Asp Asn Pro Arg Ala Ser Ser Pro Ser 
        675                 680                 685             


Arg Thr Ile Gln Gln Glu Asn Pro Arg Thr Ser Cys Ala Gln Arg Asp 
    690                 695                 700                 


Asp Pro Arg Ala Ser Ser Pro Asn Arg Thr Thr His Pro Pro His Thr 
705                 710                 715                 720 


His Thr His Thr His Thr His Thr Gln Thr His Arg His Ile Arg Thr 
                725                 730                 735     


His Val His Thr Cys Thr His Gly Tyr Thr His Thr His Thr His Cys 
            740                 745                 750         


Ile Ser Glu Arg Ala Pro Arg Thr Gly Ser His Leu Ala Pro Ser Ser 
        755                 760                 765             


Gly Phe Tyr Met 
    770         

<210>  3631
<211>  10144
<212>  DNA
<213>  Homo sapiens

<400>  3631
cttccacctc ccgagcatcg ctctgattca ttgttaaaat aaagaggcca tgaccctggc     60

actcccaccc cggcagcccc tgtgcgtgga aacccagcca aggtctgatg atggaggagc    120

cttggccctg gctgtcccag gggaggaggt gaaattcctc agctctccac caagattggc    180

cacaaaagcc tgatcccctg gaacacagca ggcctcacat agacggtcag ccattggatc    240

ataggaactg ccctggcctg actcacccaa tatggaggag gtgcctgggg atgccctgtg    300

tgaacacttt gaggccaaca tacttaccca gaaccgctgt caaaactgct tccaccctga    360

ggaggcccat ggagcaagat accaggagct caggagccct tcaggtgctg aggtgcccta    420

ctgcgacctg cctcgatgtc cacctgcccc tgaggaccca ctcagcgcct caacctccgg    480

ctgccagtct gtggtggacc caggcctcag gccagggccc aagaggggcc catccccctc    540

agcagggctc ccagaagagg gtcccacagc tgcccccagg agcaggagcc gggagcttga    600

ggcagtaccc tatctggagg gcctgaccac ttccttgtgt ggcagctgca acgaggaccc    660

cggctctgac cccacctcca gccctgactc cgccacccct gatgatacca gcaactcgtc    720

ctctgtggac tgggacactg ttgagaggca ggaggaggag gcccccagct gggacgagct    780

cgcagtgatg atcccgagga ggcctcggga ggggccgaga gctgacagct cccaaagggc    840

tccgtctctc ctcaccaggt cccctgtggg aggagatgct gcaggccaga aaaaggagga    900

caccggcggt gggggccgga gcgcaggaca gcactgggca aggctccggg gagaaagcgg    960

gttgtccctg gagcggcacc ggtcaacact gacccaggct tcctccatga caccacacag   1020

tggacctcga agcaccacgt ctcaggcttc tcctgcccaa agggacactg ctcaggctgc   1080

ctctacacgt gaaatcccca gagcctcctc tccccatcga atcacccaaa gggacacctc   1140

cagggcctca tccacccaac aggaaatctc cagggcctca tccacccaac aggaaacctc   1200

cagggcctca tccacccaag aggacacccc tagggcctca tccacccaag aggacacccc   1260

cagggcctca tctacacagt ggaacacccc cagagcttcc tctccctcac gaagcaccca   1320

actggataac cccagaacct cttctaccca gcaggacaac ccccaaactt cttttcctac   1380

ttgtactccc cagcgggaaa accccaggac accctgtgtc cagcaggacg atcccagagc   1440

ctcctctccc aacagaacca ctcaacgaga gaattccaga acatcctgtg cccagcggga   1500

caatcccaaa gcctccagaa cctcctctcc caatagagcc acacgagaca accccagaac   1560

atcctgcgcc cagcgggaca atcccagagc ctcctctccc agtagagcta cacgagacaa   1620

ccccacaaca tcctgtgccc agcgggacaa tcccagagcc tccagaacct cctctcccaa   1680

tagagccaca cgagacaacc ccagaacatc ctgtgcccag cgggacaatc ccagagcctc   1740

ctctcccagt agagctacac gagacaaccc cacaacatcc tgtgcccagc gggacaatcc   1800

cagagcctcc agaacctcct ctcccaatag agccacacga gacaacccca gaacatcctg   1860

cgcccagcgg gacaatccca gagcctcctc tcccaataga gctgcacgag acaaccccac   1920

aacatcctgt gcccagcggg acaatcccag agcctccaga acctcctctc ccaatagagc   1980

cacacgagac aaccccagaa catcctgtgc ccagcgggac aatcccagag cctcctctcc   2040

caatagagct acacgagaca accccacaac atcctgtgcc cagcgggaca atcccagagc   2100

ctccagaacc tcctctccca atagagccac acgagataac cccagaacat cctgtgccca   2160

gcgggacaat cccagagcct cctctcccaa cagaaccacc caacaagaca gccccagaac   2220

atcctgtgcc cgacgggacg atcccagagc ctcctctcct aacagaacca tccaacaaga   2280

gaaccccaga acatcctgtg ccctacggga caatcccaga gcctcctctc ccagcagaac   2340

catccaacaa gagaacccca gaacatcctg tgcccaacgg gacgatccca gagcctcctc   2400

tcctaacaga accacccaac aagagaaccc cagaacatcc tgtgcccgac gggacaatcc   2460

cagagcctcc tctcgcaaca gaaccatcca gcgagacaac cccagaacat cctgtgccca   2520

gcgggacaat cccagagcct cctctcctaa cagaaccatc caacaagaga acctcagaac   2580

atcctgtacc cgacaggaca atcccaggac ctcctctccc aatagagcca cacgagacaa   2640

ccccagaaca tcctgtgccc agcgggacaa tctcagagcc tcctctccca tcagagccac   2700

ccaacaggac aaccccagaa cttgtattca acagaacatc cccagatcat cttctaccca   2760

acaagacaac cctaaaacct cttgtaccaa acgagataac ctcagaccca cttgtacaca   2820

gcgggaccgc acacagtcct tttcctttca acgagacaac cctggaacct cctcatctca   2880

atgctgcacc caaaaggaga atctgagacc atcatctccc caccgctcca ctcaatggaa   2940

caatcccagg aattcatctc cccatcgtac taacaaagac atcccctggg cctcgtttcc   3000

cctccggcca actcagagtg atggtccccg aacctcttcc ccatctcgct ccaagcaaag   3060

cgaggttccc tgggcatcca tcgccctccg gccaacccaa ggtgacaggc ctcagacatc   3120

ctctcccagc aggccagccc agcatgaccc accccagtcc tcctttggcc ccacccagta   3180

caacttgcca tcccgggcca cctcttcctc ccataaccca ggccaccaga gcacctcccg   3240

aacttcctca cctgtgtacc ccgctgccta tggggctccc ctgacctctc ctgagccctc   3300

ccagcctcca tgtgctgtgt gcattgggca ccgggatgcc cctcgagcct cttcgccccc   3360

tcgctatttg cagcacgacc ccttcccctt cttcccagag ccccgcgccc ctgagagtga   3420

accgccccac cacgagcctc cctatatacc acctgctgtg tgcattggac accgagatgc   3480

cccccgggcg tcctcgcccc cccgccacac ccaatttgac cccttcccct tcctcccaga   3540

cacatcagat gccgagcatc agtgtcagtc cccccaacac gagccccttc agctccctgc   3600

acctgtgtgt attgggtacc gagatgcacc ccgggcctcc tccccaccac gccaggcccc   3660

agagccttcc ctcttattcc aggacctccc cagggccagc acagagagcc ttgtcccttc   3720

catggactct ctgcacgagt gcccccacat ccccacccct gtgtgcattg ggcaccggga   3780

tgcaccctcc ttctcatccc caccacgcca ggctcctgag ccatccctct tcttccagga   3840

tccccctgga actagtatgg agagcctggc cccctccact gactctctgc atggctcccc   3900

agtgctgatc ccccaagtgt gcatcgggca ccgggatgca ccccgagcct cctccccacc   3960

ccgccaccca cccagtgacc tagcgttcct ggcaccctca ccttcaccgg gcagctctgg   4020

gggctcccgg ggctcagcgc ctcccgggga gaccaggcac aacttggagc gggaggagta   4080

cactgtgctg gccgacctgc ccccacccag gaggctggcc cagagacagc cagggcccca   4140

ggcgcagtgc agcagcgggg gccgcaccca cagccctggc cgtgcagagg tggagcgcct   4200

cttcgggcaa gagcgcagga agtccgaggc agcgggggcc ttccaggccc aggacgaggg   4260

acggtcacag cagcccagcc aaggccagag ccaacttctc cgaagacagt ccagccctgc   4320

ccccagcagg caggtgacca tgctccctgc caaacaggca gaactgaccc ggcggagcca   4380

agcagagccc cctcatcctt ggagtcctga gaagagacct gagggagatc ggcagctcca   4440

ggggtccccg ctgcccccca ggacatcagc caggacccct gagagggagc tgcggacaca   4500

gagacctctg gagagtggcc aagcaggccc aagacagcct ctgggggtgt ggcagagtca   4560

ggaggaaccg ccagggtccc agggccctca tagacaccta gaaaggagct ggagcagcca   4620

ggagggaggc ctgggccctg ggggctggtg gggatgtgga gagcccagcc tgggggcagc   4680

caaagccccg gagggagcat gggggggcac ttccagggag tacaaggaga gctgggggca   4740

gccagaggcc tgggaggaga agcccactca tgagctcccc agagaactag gaaagagaag   4800

cccactcacg agcccccctg agaactgggg aggccccgca gagtcctcac aatcctggca   4860

ctctgggaca cccactgctg tgggctgggg ggcagaggga gcgtgtccat acccgcgtgg   4920

ctctgagagg cgacccgagc ttgactggag ggatctgctt ggccttctcc gggcaccagg   4980

agagggggtc tgggcccgtg tccccagcct ggactgggag ggcctcttgg agctcctgca   5040

ggccaggctg ccccgcaagg acccagctgg acacagggat gacctggcca gggctttagg   5100

gccagagctg ggtcccccag gcacaaacga tgtccctgag caggagtcac acagccagcc   5160

agaaggctgg gccgaggcca ccccagtcaa tggacacagc cccgcactgc agtcccagag   5220

cccggtccag ctgcccagcc ctgcctgcac ctccacccag tggccaaaga tcaaagtgac   5280

aagaggacca gcgaccgcaa ctctggcagg cctggagcag acgggccccc tggggagcag   5340

gagcactgcg aagggcccca gcttgccaga gctgcagttc caaccagagg agcctgagga   5400

gtcagaacca agcagaggcc aagaccccct gactgaccag aagcaggcag actcggcaga   5460

caagaggcca gcagagggca aggctgggag cccgctcaag ggccgactgg tgacctcatg   5520

gcggatgccc ggggaccggc ccacgctgtt caatccgttc ctgctgtctc tgggggtcct   5580

caggtggcga aggcccgatc tgctcaactt caagaaggga tggatgtcga tcttggacga   5640

gcctggagag cctccctccc cctcgctcac caccacctct acttcgcagt ggaagaaaca   5700

ttggtttgtg ctgacagatt caagtctcaa atattacaga gactccactg ctgaggaggc   5760

agatgagctg gatggtgaga tcgacctgcg ttcctgcacg gatgtcactg agtacgcggt   5820

gcagcgcaac tatggcttcc agatccacac caaggatgct gtctatacct tgtcggccat   5880

gacctcaggc atccggcgga actggatcga ggctctgaga aagaccgtac gtccaacttc   5940

agccccagat gtcaccaagc tctcggactc taacaaggag aacgcgctgc acagctacag   6000

cacccagaag ggccccctga aggcagggga gcagcgggcg ggctctgagg tcatcagccg   6060

gggtggccct cggaaggcgg acgggcagcg tcaggccttg gactacgtgg agctctcgcc   6120

gctgacccag gcttccccgc agcgggcccg caccccagcc cgcactcctg accgcctggc   6180

caagcaggag gagctggagc gggacctggc ccagcgctcc gaggagcggc gcaagtggtt   6240

tgaggccaca gacagcagga ccccagaggt gcctgctggt gaggggccgc gccggggcct   6300

gggtgccccc ctgactgagg accagcaaaa ccggcttagt gaggagatcg agaagaagtg   6360

gcaggagctg gagaagctgc ccctgcggga gaataagcgg gtgcccctca ctgccctgct   6420

caaccaaagc cgcggagagc gccgagggcc cccaagtgac ggccacgagg cactggagaa   6480

ggaggttcag gctcttcggg cccagctgga ggcgtggcgt ctccaagggg aggctcctca   6540

gagtgcactg agatcccagg aggatggcca catccccccg ggctacatct cacaggaggc   6600

atgtgagcgc agcctggcag agatggagtc ctcgcaccag caggtgatgg aggagctgca   6660

gcggcaccac gagcgggagc tgcagcgcct gcagcaggag aaggagtggc tcctggctga   6720

ggagacggca gccacggcct cagccattga agccatgaag aaggcctacc aggaagagct   6780

gagccgagag ctgagcaaaa cacggagtct ccagcagggc ccggatggcc tccggaagca   6840

gcaccagtca gatgtggagg cactgaagcg agagctgcag gtgctatcgg agcagtactc   6900

gcagaagtgc ctggagattg gggcactcat gcggcaggct gaggagcgcg agcacacgct   6960

gcgccgctgc cagcaggagg gccaggagct gctgcgccac aaccaggagc tgcatggccg   7020

cctgtcagag gagatagacc agctgcgcgg cttcattgcc tcgcagggca tgggcaatgg   7080

ctgcgggcgc agcaacgagc ggagttcctg cgagctagag gtgctgcttc gcgtaaaaga   7140

aaacgaactc cagtacctaa agaaggaggt gcagtgcctc cgggacgagc tccagatgat   7200

gcagaaggac aagcgcttca cctcgggaaa gtaccaggac gtctatgtgg agctgagcca   7260

catcaagaca cggtctgagc gggagatcga gcagctgaag gagcacctgc gtcttgccat   7320

ggccgccctc caggagaagg agtcgatgcg caacagcctg gctgagtaga ggtcccgccc   7380

agctgcagac cctccaggct ggaggaccag ccgccctcct tccctcctgg atggaagtaa   7440

aaagccaagc tttctcccca ccctctgtgg gccacacgtg cacttgcacc caccacacac   7500

acacacacac acacacacac acacacagac acacagacac atacgcacac acgtgcacac   7560

atgtacacac ggatacacac acacacacac acactgcata tctgagcgcg cccctcgcac   7620

tgggtctcac cttgcacctt cttcaggatt ttatatgtga agagattttt atatagattt   7680

ttttcctttt tttccaaaac actttatact ttaaaaaaaa aaaaaaaaag caattcctgg   7740

tggctgtgtg cctccaaccc tggtccccct ctgtctccag ccaccctctg cttgggcttc   7800

tgagctggtg gccctggccc agaggtctgg cggaggccca ggcagcagcc atggcggggt   7860

gtctctacag gggagaggcg ggagcctgcc accctcttcc tgccctacct cctactaaca   7920

cttcctgccc catttggacc cgtaccatgg ggctcaggac agagggagct agcagctggc   7980

ctccatggcc ccacagcctc cttcgaggct gtgctgggtg cagaaccgcc agagccaccc   8040

aaaaggtgtt tctcttctgc tccctgaacc tcttaactta ataaaacgtt ccagcagctc   8100

tggtgtccta gatggctggc agaacaggaa tggagattgg ggtttcttga agtggcttcc   8160

ccactcacac cctacccaca ccccaccctt cctaaagcag cggcctctag gcttctgagg   8220

gtggggctga aaatccaagg tctcccttag tacagactgt gacgccccca gtgtggcttg   8280

caggctagtg gcagcggaag catgtgggaa atagcaagtc cagtcccacc ccaacctact   8340

gaaccagcgt ctgcatttta acagggtgcc ccagtgattc acgtgacctt caaagtctga   8400

ggagccctgg agtagggccc agggcccagg cctgagagag aggcctgggg ctaagactag   8460

ccctgaccat gaccttgggc aagtcacacc cctcactgag cctcagtttg cttctccatc   8520

aaatgggtgt ttttctttca gtcccagtcc tctcctgagg cttttcccag aggtcatgcc   8580

cagccctggg caggggtgag ggcagggttg tggctgccag gcacaggtcc agcgggctgg   8640

gagtcctcac catggctggc tgtgctgatt atggttgcat ggggctggga agaggtccca   8700

tttctgagcc acagaaacag gccacatcca gtaggggtcc tggaaggctg tgagaaccca   8760

gaggagaccc tgacccagcc tgcaggtaga agactgcctt tggaggcagc tttgaaagat   8820

gactcttcca gatggaagaa tcaggaaggg ccttcccacg tggaggcacc agcaggagca   8880

aacgtccctg gtgtgttcag gcaaagagcc acaggagagt gacctcgtgg agtgggaaga   8940

gattgtttcc cattcccttg ccagggattg gttgaggaat ggacaaggct tgcagttcac   9000

gcaagccagt gaaatgcgag gggaagtctt gggagtgggg tggaggaggt catctgggaa   9060

gggtgtcctt ggtcttaaaa agaggcacaa gaggccgggc gcggtggctc ttgcctatta   9120

tcctagcact ttgggaggcc aaggcagggg gatcacttga ggtcaggagt tcgagaccag   9180

cctggccaac atggtgaaac cccgtctcta ctaaaaatac aaaaaattag ccagacgtgg   9240

tgccaagcac ctgtaatccc agctactcag gaggctgagg caggagaatc acttgaaccc   9300

aggaggcaga agttgcagtg agccaagatc gcgccactgc actccagcct gtgtgacaag   9360

ggcgaaactc catctcaaaa aaaaaggggg agggtggcgc aaggagagga cacctctctc   9420

ctggccctgt cgccatcttc cctcatcaat agctaaaaat ggcaaagaag aaagagccag   9480

gaccccgtgc catcaaatcc tccggccttg tgctgccctg tctcggcact gcttgcctta   9540

ggagatcagg agtgttccta gccactggga gatgggatgc ctgccactgg cagctctgcc   9600

gtccatcctc accatcccac cgtcccccca agacagctct ccatcccatc ctctgcctcc   9660

cttctagcct caacctaact cagggctccc ccgtctcaca cctgggttgc aggaacatcc   9720

tcttcaccaa cccccctccc atccctcctc agggctgcct agggcagcta caaaaaccag   9780

gccagcctct gaaaggtgct ccacatctca ttaaaaaccg tgaaatcgca ctgccccact   9840

atcagaatag ctcagaggag aaggtctgcc agtaccaagt gctggtgggg atacggagaa   9900

gagcagctcc caggcgctgc tggtgcaaat gtgctttgtt gcacccacgg caggaaactg   9960

accagcttct catcaagtta aatacgcatc taccctatgg cctagcattt ccactcttgc  10020

ttacacatcc aggagaaatg agtccttaca tgcacaaaag gatgagtacc gtaatactca  10080

catcagcaaa taaacaatac agctgtgtgt cagtagtaga atgaataaat tgtggtcgat  10140

tcat                                                               10144


<210>  3632
<211>  2365
<212>  PRT
<213>  Homo sapiens

<400>  3632


Met Glu Glu Val Pro Gly Asp Ala Leu Cys Glu His Phe Glu Ala Asn 
1               5                   10                  15      


Ile Leu Thr Gln Asn Arg Cys Gln Asn Cys Phe His Pro Glu Glu Ala 
            20                  25                  30          


His Gly Ala Arg Tyr Gln Glu Leu Arg Ser Pro Ser Gly Ala Glu Val 
        35                  40                  45              


Pro Tyr Cys Asp Leu Pro Arg Cys Pro Pro Ala Pro Glu Asp Pro Leu 
    50                  55                  60                  


Ser Ala Ser Thr Ser Gly Cys Gln Ser Val Val Asp Pro Gly Leu Arg 
65                  70                  75                  80  


Pro Gly Pro Lys Arg Gly Pro Ser Pro Ser Ala Gly Leu Pro Glu Glu 
                85                  90                  95      


Gly Pro Thr Ala Ala Pro Arg Ser Arg Ser Arg Glu Leu Glu Ala Val 
            100                 105                 110         


Pro Tyr Leu Glu Gly Leu Thr Thr Ser Leu Cys Gly Ser Cys Asn Glu 
        115                 120                 125             


Asp Pro Gly Ser Asp Pro Thr Ser Ser Pro Asp Ser Ala Thr Pro Asp 
    130                 135                 140                 


Asp Thr Ser Asn Ser Ser Ser Val Asp Trp Asp Thr Val Glu Arg Gln 
145                 150                 155                 160 


Glu Glu Glu Ala Pro Ser Trp Asp Glu Leu Ala Val Met Ile Pro Arg 
                165                 170                 175     


Arg Pro Arg Glu Gly Pro Arg Ala Asp Ser Ser Gln Arg Ala Pro Ser 
            180                 185                 190         


Leu Leu Thr Arg Ser Pro Val Gly Gly Asp Ala Ala Gly Gln Lys Lys 
        195                 200                 205             


Glu Asp Thr Gly Gly Gly Gly Arg Ser Ala Gly Gln His Trp Ala Arg 
    210                 215                 220                 


Leu Arg Gly Glu Ser Gly Leu Ser Leu Glu Arg His Arg Ser Thr Leu 
225                 230                 235                 240 


Thr Gln Ala Ser Ser Met Thr Pro His Ser Gly Pro Arg Ser Thr Thr 
                245                 250                 255     


Ser Gln Ala Ser Pro Ala Gln Arg Asp Thr Ala Gln Ala Ala Ser Thr 
            260                 265                 270         


Arg Glu Ile Pro Arg Ala Ser Ser Pro His Arg Ile Thr Gln Arg Asp 
        275                 280                 285             


Thr Ser Arg Ala Ser Ser Thr Gln Gln Glu Ile Ser Arg Ala Ser Ser 
    290                 295                 300                 


Thr Gln Gln Glu Thr Ser Arg Ala Ser Ser Thr Gln Glu Asp Thr Pro 
305                 310                 315                 320 


Arg Ala Ser Ser Thr Gln Glu Asp Thr Pro Arg Ala Ser Ser Thr Gln 
                325                 330                 335     


Trp Asn Thr Pro Arg Ala Ser Ser Pro Ser Arg Ser Thr Gln Leu Asp 
            340                 345                 350         


Asn Pro Arg Thr Ser Ser Thr Gln Gln Asp Asn Pro Gln Thr Ser Phe 
        355                 360                 365             


Pro Thr Cys Thr Pro Gln Arg Glu Asn Pro Arg Thr Pro Cys Val Gln 
    370                 375                 380                 


Gln Asp Asp Pro Arg Ala Ser Ser Pro Asn Arg Thr Thr Gln Arg Glu 
385                 390                 395                 400 


Asn Ser Arg Thr Ser Cys Ala Gln Arg Asp Asn Pro Lys Ala Ser Arg 
                405                 410                 415     


Thr Ser Ser Pro Asn Arg Ala Thr Arg Asp Asn Pro Arg Thr Ser Cys 
            420                 425                 430         


Ala Gln Arg Asp Asn Pro Arg Ala Ser Ser Pro Ser Arg Ala Thr Arg 
        435                 440                 445             


Asp Asn Pro Thr Thr Ser Cys Ala Gln Arg Asp Asn Pro Arg Ala Ser 
    450                 455                 460                 


Arg Thr Ser Ser Pro Asn Arg Ala Thr Arg Asp Asn Pro Arg Thr Ser 
465                 470                 475                 480 


Cys Ala Gln Arg Asp Asn Pro Arg Ala Ser Ser Pro Ser Arg Ala Thr 
                485                 490                 495     


Arg Asp Asn Pro Thr Thr Ser Cys Ala Gln Arg Asp Asn Pro Arg Ala 
            500                 505                 510         


Ser Arg Thr Ser Ser Pro Asn Arg Ala Thr Arg Asp Asn Pro Arg Thr 
        515                 520                 525             


Ser Cys Ala Gln Arg Asp Asn Pro Arg Ala Ser Ser Pro Asn Arg Ala 
    530                 535                 540                 


Ala Arg Asp Asn Pro Thr Thr Ser Cys Ala Gln Arg Asp Asn Pro Arg 
545                 550                 555                 560 


Ala Ser Arg Thr Ser Ser Pro Asn Arg Ala Thr Arg Asp Asn Pro Arg 
                565                 570                 575     


Thr Ser Cys Ala Gln Arg Asp Asn Pro Arg Ala Ser Ser Pro Asn Arg 
            580                 585                 590         


Ala Thr Arg Asp Asn Pro Thr Thr Ser Cys Ala Gln Arg Asp Asn Pro 
        595                 600                 605             


Arg Ala Ser Arg Thr Ser Ser Pro Asn Arg Ala Thr Arg Asp Asn Pro 
    610                 615                 620                 


Arg Thr Ser Cys Ala Gln Arg Asp Asn Pro Arg Ala Ser Ser Pro Asn 
625                 630                 635                 640 


Arg Thr Thr Gln Gln Asp Ser Pro Arg Thr Ser Cys Ala Arg Arg Asp 
                645                 650                 655     


Asp Pro Arg Ala Ser Ser Pro Asn Arg Thr Ile Gln Gln Glu Asn Pro 
            660                 665                 670         


Arg Thr Ser Cys Ala Leu Arg Asp Asn Pro Arg Ala Ser Ser Pro Ser 
        675                 680                 685             


Arg Thr Ile Gln Gln Glu Asn Pro Arg Thr Ser Cys Ala Gln Arg Asp 
    690                 695                 700                 


Asp Pro Arg Ala Ser Ser Pro Asn Arg Thr Thr Gln Gln Glu Asn Pro 
705                 710                 715                 720 


Arg Thr Ser Cys Ala Arg Arg Asp Asn Pro Arg Ala Ser Ser Arg Asn 
                725                 730                 735     


Arg Thr Ile Gln Arg Asp Asn Pro Arg Thr Ser Cys Ala Gln Arg Asp 
            740                 745                 750         


Asn Pro Arg Ala Ser Ser Pro Asn Arg Thr Ile Gln Gln Glu Asn Leu 
        755                 760                 765             


Arg Thr Ser Cys Thr Arg Gln Asp Asn Pro Arg Thr Ser Ser Pro Asn 
    770                 775                 780                 


Arg Ala Thr Arg Asp Asn Pro Arg Thr Ser Cys Ala Gln Arg Asp Asn 
785                 790                 795                 800 


Leu Arg Ala Ser Ser Pro Ile Arg Ala Thr Gln Gln Asp Asn Pro Arg 
                805                 810                 815     


Thr Cys Ile Gln Gln Asn Ile Pro Arg Ser Ser Ser Thr Gln Gln Asp 
            820                 825                 830         


Asn Pro Lys Thr Ser Cys Thr Lys Arg Asp Asn Leu Arg Pro Thr Cys 
        835                 840                 845             


Thr Gln Arg Asp Arg Thr Gln Ser Phe Ser Phe Gln Arg Asp Asn Pro 
    850                 855                 860                 


Gly Thr Ser Ser Ser Gln Cys Cys Thr Gln Lys Glu Asn Leu Arg Pro 
865                 870                 875                 880 


Ser Ser Pro His Arg Ser Thr Gln Trp Asn Asn Pro Arg Asn Ser Ser 
                885                 890                 895     


Pro His Arg Thr Asn Lys Asp Ile Pro Trp Ala Ser Phe Pro Leu Arg 
            900                 905                 910         


Pro Thr Gln Ser Asp Gly Pro Arg Thr Ser Ser Pro Ser Arg Ser Lys 
        915                 920                 925             


Gln Ser Glu Val Pro Trp Ala Ser Ile Ala Leu Arg Pro Thr Gln Gly 
    930                 935                 940                 


Asp Arg Pro Gln Thr Ser Ser Pro Ser Arg Pro Ala Gln His Asp Pro 
945                 950                 955                 960 


Pro Gln Ser Ser Phe Gly Pro Thr Gln Tyr Asn Leu Pro Ser Arg Ala 
                965                 970                 975     


Thr Ser Ser Ser His Asn Pro Gly His Gln Ser Thr Ser Arg Thr Ser 
            980                 985                 990         


Ser Pro Val Tyr Pro Ala Ala Tyr  Gly Ala Pro Leu Thr  Ser Pro Glu 
        995                 1000                 1005             


Pro Ser  Gln Pro Pro Cys Ala  Val Cys Ile Gly His  Arg Asp Ala 
    1010                 1015                 1020             


Pro Arg  Ala Ser Ser Pro Pro  Arg Tyr Leu Gln His  Asp Pro Phe 
    1025                 1030                 1035             


Pro Phe  Phe Pro Glu Pro Arg  Ala Pro Glu Ser Glu  Pro Pro His 
    1040                 1045                 1050             


His Glu  Pro Pro Tyr Ile Pro  Pro Ala Val Cys Ile  Gly His Arg 
    1055                 1060                 1065             


Asp Ala  Pro Arg Ala Ser Ser  Pro Pro Arg His Thr  Gln Phe Asp 
    1070                 1075                 1080             


Pro Phe  Pro Phe Leu Pro Asp  Thr Ser Asp Ala Glu  His Gln Cys 
    1085                 1090                 1095             


Gln Ser  Pro Gln His Glu Pro  Leu Gln Leu Pro Ala  Pro Val Cys 
    1100                 1105                 1110             


Ile Gly  Tyr Arg Asp Ala Pro  Arg Ala Ser Ser Pro  Pro Arg Gln 
    1115                 1120                 1125             


Ala Pro  Glu Pro Ser Leu Leu  Phe Gln Asp Leu Pro  Arg Ala Ser 
    1130                 1135                 1140             


Thr Glu  Ser Leu Val Pro Ser  Met Asp Ser Leu His  Glu Cys Pro 
    1145                 1150                 1155             


His Ile  Pro Thr Pro Val Cys  Ile Gly His Arg Asp  Ala Pro Ser 
    1160                 1165                 1170             


Phe Ser  Ser Pro Pro Arg Gln  Ala Pro Glu Pro Ser  Leu Phe Phe 
    1175                 1180                 1185             


Gln Asp  Pro Pro Gly Thr Ser  Met Glu Ser Leu Ala  Pro Ser Thr 
    1190                 1195                 1200             


Asp Ser  Leu His Gly Ser Pro  Val Leu Ile Pro Gln  Val Cys Ile 
    1205                 1210                 1215             


Gly His  Arg Asp Ala Pro Arg  Ala Ser Ser Pro Pro  Arg His Pro 
    1220                 1225                 1230             


Pro Ser  Asp Leu Ala Phe Leu  Ala Pro Ser Pro Ser  Pro Gly Ser 
    1235                 1240                 1245             


Ser Gly  Gly Ser Arg Gly Ser  Ala Pro Pro Gly Glu  Thr Arg His 
    1250                 1255                 1260             


Asn Leu  Glu Arg Glu Glu Tyr  Thr Val Leu Ala Asp  Leu Pro Pro 
    1265                 1270                 1275             


Pro Arg  Arg Leu Ala Gln Arg  Gln Pro Gly Pro Gln  Ala Gln Cys 
    1280                 1285                 1290             


Ser Ser  Gly Gly Arg Thr His  Ser Pro Gly Arg Ala  Glu Val Glu 
    1295                 1300                 1305             


Arg Leu  Phe Gly Gln Glu Arg  Arg Lys Ser Glu Ala  Ala Gly Ala 
    1310                 1315                 1320             


Phe Gln  Ala Gln Asp Glu Gly  Arg Ser Gln Gln Pro  Ser Gln Gly 
    1325                 1330                 1335             


Gln Ser  Gln Leu Leu Arg Arg  Gln Ser Ser Pro Ala  Pro Ser Arg 
    1340                 1345                 1350             


Gln Val  Thr Met Leu Pro Ala  Lys Gln Ala Glu Leu  Thr Arg Arg 
    1355                 1360                 1365             


Ser Gln  Ala Glu Pro Pro His  Pro Trp Ser Pro Glu  Lys Arg Pro 
    1370                 1375                 1380             


Glu Gly  Asp Arg Gln Leu Gln  Gly Ser Pro Leu Pro  Pro Arg Thr 
    1385                 1390                 1395             


Ser Ala  Arg Thr Pro Glu Arg  Glu Leu Arg Thr Gln  Arg Pro Leu 
    1400                 1405                 1410             


Glu Ser  Gly Gln Ala Gly Pro  Arg Gln Pro Leu Gly  Val Trp Gln 
    1415                 1420                 1425             


Ser Gln  Glu Glu Pro Pro Gly  Ser Gln Gly Pro His  Arg His Leu 
    1430                 1435                 1440             


Glu Arg  Ser Trp Ser Ser Gln  Glu Gly Gly Leu Gly  Pro Gly Gly 
    1445                 1450                 1455             


Trp Trp  Gly Cys Gly Glu Pro  Ser Leu Gly Ala Ala  Lys Ala Pro 
    1460                 1465                 1470             


Glu Gly  Ala Trp Gly Gly Thr  Ser Arg Glu Tyr Lys  Glu Ser Trp 
    1475                 1480                 1485             


Gly Gln  Pro Glu Ala Trp Glu  Glu Lys Pro Thr His  Glu Leu Pro 
    1490                 1495                 1500             


Arg Glu  Leu Gly Lys Arg Ser  Pro Leu Thr Ser Pro  Pro Glu Asn 
    1505                 1510                 1515             


Trp Gly  Gly Pro Ala Glu Ser  Ser Gln Ser Trp His  Ser Gly Thr 
    1520                 1525                 1530             


Pro Thr  Ala Val Gly Trp Gly  Ala Glu Gly Ala Cys  Pro Tyr Pro 
    1535                 1540                 1545             


Arg Gly  Ser Glu Arg Arg Pro  Glu Leu Asp Trp Arg  Asp Leu Leu 
    1550                 1555                 1560             


Gly Leu  Leu Arg Ala Pro Gly  Glu Gly Val Trp Ala  Arg Val Pro 
    1565                 1570                 1575             


Ser Leu  Asp Trp Glu Gly Leu  Leu Glu Leu Leu Gln  Ala Arg Leu 
    1580                 1585                 1590             


Pro Arg  Lys Asp Pro Ala Gly  His Arg Asp Asp Leu  Ala Arg Ala 
    1595                 1600                 1605             


Leu Gly  Pro Glu Leu Gly Pro  Pro Gly Thr Asn Asp  Val Pro Glu 
    1610                 1615                 1620             


Gln Glu  Ser His Ser Gln Pro  Glu Gly Trp Ala Glu  Ala Thr Pro 
    1625                 1630                 1635             


Val Asn  Gly His Ser Pro Ala  Leu Gln Ser Gln Ser  Pro Val Gln 
    1640                 1645                 1650             


Leu Pro  Ser Pro Ala Cys Thr  Ser Thr Gln Trp Pro  Lys Ile Lys 
    1655                 1660                 1665             


Val Thr  Arg Gly Pro Ala Thr  Ala Thr Leu Ala Gly  Leu Glu Gln 
    1670                 1675                 1680             


Thr Gly  Pro Leu Gly Ser Arg  Ser Thr Ala Lys Gly  Pro Ser Leu 
    1685                 1690                 1695             


Pro Glu  Leu Gln Phe Gln Pro  Glu Glu Pro Glu Glu  Ser Glu Pro 
    1700                 1705                 1710             


Ser Arg  Gly Gln Asp Pro Leu  Thr Asp Gln Lys Gln  Ala Asp Ser 
    1715                 1720                 1725             


Ala Asp  Lys Arg Pro Ala Glu  Gly Lys Ala Gly Ser  Pro Leu Lys 
    1730                 1735                 1740             


Gly Arg  Leu Val Thr Ser Trp  Arg Met Pro Gly Asp  Arg Pro Thr 
    1745                 1750                 1755             


Leu Phe  Asn Pro Phe Leu Leu  Ser Leu Gly Val Leu  Arg Trp Arg 
    1760                 1765                 1770             


Arg Pro  Asp Leu Leu Asn Phe  Lys Lys Gly Trp Met  Ser Ile Leu 
    1775                 1780                 1785             


Asp Glu  Pro Gly Glu Pro Pro  Ser Pro Ser Leu Thr  Thr Thr Ser 
    1790                 1795                 1800             


Thr Ser  Gln Trp Lys Lys His  Trp Phe Val Leu Thr  Asp Ser Ser 
    1805                 1810                 1815             


Leu Lys  Tyr Tyr Arg Asp Ser  Thr Ala Glu Glu Ala  Asp Glu Leu 
    1820                 1825                 1830             


Asp Gly  Glu Ile Asp Leu Arg  Ser Cys Thr Asp Val  Thr Glu Tyr 
    1835                 1840                 1845             


Ala Val  Gln Arg Asn Tyr Gly  Phe Gln Ile His Thr  Lys Asp Ala 
    1850                 1855                 1860             


Val Tyr  Thr Leu Ser Ala Met  Thr Ser Gly Ile Arg  Arg Asn Trp 
    1865                 1870                 1875             


Ile Glu  Ala Leu Arg Lys Thr  Val Arg Pro Thr Ser  Ala Pro Asp 
    1880                 1885                 1890             


Val Thr  Lys Leu Ser Asp Ser  Asn Lys Glu Asn Ala  Leu His Ser 
    1895                 1900                 1905             


Tyr Ser  Thr Gln Lys Gly Pro  Leu Lys Ala Gly Glu  Gln Arg Ala 
    1910                 1915                 1920             


Gly Ser  Glu Val Ile Ser Arg  Gly Gly Pro Arg Lys  Ala Asp Gly 
    1925                 1930                 1935             


Gln Arg  Gln Ala Leu Asp Tyr  Val Glu Leu Ser Pro  Leu Thr Gln 
    1940                 1945                 1950             


Ala Ser  Pro Gln Arg Ala Arg  Thr Pro Ala Arg Thr  Pro Asp Arg 
    1955                 1960                 1965             


Leu Ala  Lys Gln Glu Glu Leu  Glu Arg Asp Leu Ala  Gln Arg Ser 
    1970                 1975                 1980             


Glu Glu  Arg Arg Lys Trp Phe  Glu Ala Thr Asp Ser  Arg Thr Pro 
    1985                 1990                 1995             


Glu Val  Pro Ala Gly Glu Gly  Pro Arg Arg Gly Leu  Gly Ala Pro 
    2000                 2005                 2010             


Leu Thr  Glu Asp Gln Gln Asn  Arg Leu Ser Glu Glu  Ile Glu Lys 
    2015                 2020                 2025             


Lys Trp  Gln Glu Leu Glu Lys  Leu Pro Leu Arg Glu  Asn Lys Arg 
    2030                 2035                 2040             


Val Pro  Leu Thr Ala Leu Leu  Asn Gln Ser Arg Gly  Glu Arg Arg 
    2045                 2050                 2055             


Gly Pro  Pro Ser Asp Gly His  Glu Ala Leu Glu Lys  Glu Val Gln 
    2060                 2065                 2070             


Ala Leu  Arg Ala Gln Leu Glu  Ala Trp Arg Leu Gln  Gly Glu Ala 
    2075                 2080                 2085             


Pro Gln  Ser Ala Leu Arg Ser  Gln Glu Asp Gly His  Ile Pro Pro 
    2090                 2095                 2100             


Gly Tyr  Ile Ser Gln Glu Ala  Cys Glu Arg Ser Leu  Ala Glu Met 
    2105                 2110                 2115             


Glu Ser  Ser His Gln Gln Val  Met Glu Glu Leu Gln  Arg His His 
    2120                 2125                 2130             


Glu Arg  Glu Leu Gln Arg Leu  Gln Gln Glu Lys Glu  Trp Leu Leu 
    2135                 2140                 2145             


Ala Glu  Glu Thr Ala Ala Thr  Ala Ser Ala Ile Glu  Ala Met Lys 
    2150                 2155                 2160             


Lys Ala  Tyr Gln Glu Glu Leu  Ser Arg Glu Leu Ser  Lys Thr Arg 
    2165                 2170                 2175             


Ser Leu  Gln Gln Gly Pro Asp  Gly Leu Arg Lys Gln  His Gln Ser 
    2180                 2185                 2190             


Asp Val  Glu Ala Leu Lys Arg  Glu Leu Gln Val Leu  Ser Glu Gln 
    2195                 2200                 2205             


Tyr Ser  Gln Lys Cys Leu Glu  Ile Gly Ala Leu Met  Arg Gln Ala 
    2210                 2215                 2220             


Glu Glu  Arg Glu His Thr Leu  Arg Arg Cys Gln Gln  Glu Gly Gln 
    2225                 2230                 2235             


Glu Leu  Leu Arg His Asn Gln  Glu Leu His Gly Arg  Leu Ser Glu 
    2240                 2245                 2250             


Glu Ile  Asp Gln Leu Arg Gly  Phe Ile Ala Ser Gln  Gly Met Gly 
    2255                 2260                 2265             


Asn Gly  Cys Gly Arg Ser Asn  Glu Arg Ser Ser Cys  Glu Leu Glu 
    2270                 2275                 2280             


Val Leu  Leu Arg Val Lys Glu  Asn Glu Leu Gln Tyr  Leu Lys Lys 
    2285                 2290                 2295             


Glu Val  Gln Cys Leu Arg Asp  Glu Leu Gln Met Met  Gln Lys Asp 
    2300                 2305                 2310             


Lys Arg  Phe Thr Ser Gly Lys  Tyr Gln Asp Val Tyr  Val Glu Leu 
    2315                 2320                 2325             


Ser His  Ile Lys Thr Arg Ser  Glu Arg Glu Ile Glu  Gln Leu Lys 
    2330                 2335                 2340             


Glu His  Leu Arg Leu Ala Met  Ala Ala Leu Gln Glu  Lys Glu Ser 
    2345                 2350                 2355             


Met Arg  Asn Ser Leu Ala Glu  
    2360                 2365 

<210>  3633
<211>  5192
<212>  DNA
<213>  Homo sapiens

<400>  3633
cttccacctc ccgagcatcg ctctgattca ttgttaaaat aaagaggcca tgaccctggc     60

actcccaccc cggcagcccc tgtgcgtgga aacccagcca aggtctgatg atggaggagc    120

cttggccctg gctgtcccag gggaggaggt gaaattcctc agctctccac caagattggc    180

cacaaaagcc tgatcccctg gaacacagca ggcctcacat agacggtcag ccattggatc    240

ataggaactg ccctggcctg actcacccaa tatggaggag gtgcctgggg atgccctgtg    300

tgaacacttt gaggccaaca tacttaccca gaaccgctgt caaaactgct tccaccctga    360

ggaggcccat ggagcaagat accaggagct caggagccct tcaggtgctg aggtgcccta    420

ctgcgacctg cctcgatgtc cacctgcccc tgaggaccca ctcagcgcct caacctccgg    480

ctgccagtct gtggtggacc caggcctcag gccagggccc aagaggggcc catccccctc    540

agcagggctc ccagaagagg gtcccacagc tgcccccagg agcaggagcc gggagcttga    600

ggcagtaccc tatctggagg gcctgaccac ttccttgtgt ggcagctgca acgaggaccc    660

cggctctgac cccacctcca gccctgactc cgccacccct gatgatacca gcaactcgtc    720

ctctgtggac tgggacactg ttgagaggca ggaggaggag gcccccagct gggacgagct    780

cgcagtgatg atcccgagga ggcctcggga ggggccgaga gctgacagct cccaaagggc    840

tccgtctctc ctcaccaggt cccctgtggg aggagatgct gcaggccaga aaaaggagga    900

caccggcggt gggggccgga gcgcaggaca gcactgggca aggctccggg gagaaagcgg    960

gttgtccctg gagcggcacc ggtcaacact gacccaggct tcctccatga caccacacag   1020

tggacctcga agcaccacgt ctcaggcttc tcctgcccaa agggacactg ctcaggctgc   1080

ctctacacgt gaaatcccca gagcctcctc tccccatcga atcacccaaa gggacacctc   1140

cagggcctca tccacccaac aggaaatctc cagggcctca tccacccaac aggaaacctc   1200

cagggcctca tccacccaag aggacacccc tagggcctca tccacccaag aggacacccc   1260

cagggcctca tctacacagt ggaacacccc cagagcttcc tctccctcac gaagcaccca   1320

actggataac cccagaacct cttctaccca gcaggacaac ccccaaactt cttttcctac   1380

ttgtactccc cagcgggaaa accccaggac accctgtgtc cagcaggacg atcccagagc   1440

ctcctctccc aacagaacca ctcaacgaga gaattccaga acatcctgtg cccagcggga   1500

caatcccaaa gcctccagaa cctcctctcc caatagagcc acacgagaca accccagaac   1560

atcctgcgcc cagcgggaca atcccagagc ctcctctccc agtagagcta cacgagacaa   1620

ccccacaaca tcctgtgccc agcgggacaa tcccagagcc tccagaacct cctctcccaa   1680

tagagccaca cgagacaacc ccagaacatc ctgtgcccag cgggacaatc ccagagcctc   1740

ctctcccagt agagctacac gagacaaccc cacaacatcc tgtgcccagc gggacaatcc   1800

cagagcctcc agaacctcct ctcccaatag agccacacga gacaacccca gaacatcctg   1860

cgcccagcgg gacaatccca gagcctcctc tcccaataga gctgcacgag acaaccccac   1920

aacatcctgt gcccagcggg acaatcccag agcctccaga acctcctctc ccaatagagc   1980

cacacgagac aaccccagaa catcctgtgc ccagcgggac aatcccagag cctcctctcc   2040

caatagagct acacgagaca accccacaac atcctgtgcc cagcgggaca atcccagagc   2100

ctccagaacc tcctctccca atagagccac acgagataac cccagaacat cctgtgccca   2160

gcgggacaat cccagagcct cctctcccaa cagaaccacc caacaagaca gccccagaac   2220

atcctgtgcc cgacgggacg atcccagagc ctcctctcct aacagaacca tccaacaaga   2280

gaaccccaga acatcctgtg ccctacggga caatcccaga gcctcctctc ccagcagaac   2340

catccaacaa gagaacccca gaacatcctg tgcccaacgg gacgatccca gagcctcctc   2400

tcctaacaga accacccacc caccacacac acacacacac acacacacac acacacagac   2460

acacagacac atacgcacac acgtgcacac atgtacacac ggatacacac acacacacac   2520

acactgcata tctgagcgcg cccctcgcac tgggtctcac cttgcacctt cttcaggatt   2580

ttatatgtga agagattttt atatagattt ttttcctttt tttccaaaac actttatact   2640

ttaaaaaaaa aaaaaaaaag caattcctgg tggctgtgtg cctccaaccc tggtccccct   2700

ctgtctccag ccaccctctg cttgggcttc tgagctggtg gccctggccc agaggtctgg   2760

cggaggccca ggcagcagcc atggcggggt gtctctacag gggagaggcg ggagcctgcc   2820

accctcttcc tgccctacct cctactaaca cttcctgccc catttggacc cgtaccatgg   2880

ggctcaggac agagggagct agcagctggc ctccatggcc ccacagcctc cttcgaggct   2940

gtgctgggtg cagaaccgcc agagccaccc aaaaggtgtt tctcttctgc tccctgaacc   3000

tcttaactta ataaaacgtt ccagcagctc tggtgtccta gatggctggc agaacaggaa   3060

tggagattgg ggtttcttga agtggcttcc ccactcacac cctacccaca ccccaccctt   3120

cctaaagcag cggcctctag gcttctgagg gtggggctga aaatccaagg tctcccttag   3180

tacagactgt gacgccccca gtgtggcttg caggctagtg gcagcggaag catgtgggaa   3240

atagcaagtc cagtcccacc ccaacctact gaaccagcgt ctgcatttta acagggtgcc   3300

ccagtgattc acgtgacctt caaagtctga ggagccctgg agtagggccc agggcccagg   3360

cctgagagag aggcctgggg ctaagactag ccctgaccat gaccttgggc aagtcacacc   3420

cctcactgag cctcagtttg cttctccatc aaatgggtgt ttttctttca gtcccagtcc   3480

tctcctgagg cttttcccag aggtcatgcc cagccctggg caggggtgag ggcagggttg   3540

tggctgccag gcacaggtcc agcgggctgg gagtcctcac catggctggc tgtgctgatt   3600

atggttgcat ggggctggga agaggtccca tttctgagcc acagaaacag gccacatcca   3660

gtaggggtcc tggaaggctg tgagaaccca gaggagaccc tgacccagcc tgcaggtaga   3720

agactgcctt tggaggcagc tttgaaagat gactcttcca gatggaagaa tcaggaaggg   3780

ccttcccacg tggaggcacc agcaggagca aacgtccctg gtgtgttcag gcaaagagcc   3840

acaggagagt gacctcgtgg agtgggaaga gattgtttcc cattcccttg ccagggattg   3900

gttgaggaat ggacaaggct tgcagttcac gcaagccagt gaaatgcgag gggaagtctt   3960

gggagtgggg tggaggaggt catctgggaa gggtgtcctt ggtcttaaaa agaggcacaa   4020

gaggccgggc gcggtggctc ttgcctatta tcctagcact ttgggaggcc aaggcagggg   4080

gatcacttga ggtcaggagt tcgagaccag cctggccaac atggtgaaac cccgtctcta   4140

ctaaaaatac aaaaaattag ccagacgtgg tgccaagcac ctgtaatccc agctactcag   4200

gaggctgagg caggagaatc acttgaaccc aggaggcaga agttgcagtg agccaagatc   4260

gcgccactgc actccagcct gtgtgacaag ggcgaaactc catctcaaaa aaaaaggggg   4320

agggtggcgc aaggagagga cacctctctc ctggccctgt cgccatcttc cctcatcaat   4380

agctaaaaat ggcaaagaag aaagagccag gaccccgtgc catcaaatcc tccggccttg   4440

tgctgccctg tctcggcact gcttgcctta ggagatcagg agtgttccta gccactggga   4500

gatgggatgc ctgccactgg cagctctgcc gtccatcctc accatcccac cgtcccccca   4560

agacagctct ccatcccatc ctctgcctcc cttctagcct caacctaact cagggctccc   4620

ccgtctcaca cctgggttgc aggaacatcc tcttcaccaa cccccctccc atccctcctc   4680

agggctgcct agggcagcta caaaaaccag gccagcctct gaaaggtgct ccacatctca   4740

ttaaaaaccg tgaaatcgca ctgccccact atcagaatag ctcagaggag aaggtctgcc   4800

agtaccaagt gctggtgggg atacggagaa gagcagctcc caggcgctgc tggtgcaaat   4860

gtgctttgtt gcacccacgg caggaaactg accagcttct catcaagtta aatacgcatc   4920

taccctatgg cctagcattt ccactcttgc ttacacatcc aggagaaatg agtccttaca   4980

tgcacaaaag gatgagtacc gtaatactca catcagcaaa taaacaatac agctgtgtgt   5040

cagtagtaga atgaataaat tgtggtcgat tcatacgtta gaatacagca atttaaaaac   5100

aactgctaca cacaaaaatg ttggtgaatc tttcagacac aatgttgagc aaaaatagcc   5160

acagaagagt gtaaggctgt acgattttat tt                                 5192


<210>  3634
<211>  772
<212>  PRT
<213>  Homo sapiens

<400>  3634


Met Glu Glu Val Pro Gly Asp Ala Leu Cys Glu His Phe Glu Ala Asn 
1               5                   10                  15      


Ile Leu Thr Gln Asn Arg Cys Gln Asn Cys Phe His Pro Glu Glu Ala 
            20                  25                  30          


His Gly Ala Arg Tyr Gln Glu Leu Arg Ser Pro Ser Gly Ala Glu Val 
        35                  40                  45              


Pro Tyr Cys Asp Leu Pro Arg Cys Pro Pro Ala Pro Glu Asp Pro Leu 
    50                  55                  60                  


Ser Ala Ser Thr Ser Gly Cys Gln Ser Val Val Asp Pro Gly Leu Arg 
65                  70                  75                  80  


Pro Gly Pro Lys Arg Gly Pro Ser Pro Ser Ala Gly Leu Pro Glu Glu 
                85                  90                  95      


Gly Pro Thr Ala Ala Pro Arg Ser Arg Ser Arg Glu Leu Glu Ala Val 
            100                 105                 110         


Pro Tyr Leu Glu Gly Leu Thr Thr Ser Leu Cys Gly Ser Cys Asn Glu 
        115                 120                 125             


Asp Pro Gly Ser Asp Pro Thr Ser Ser Pro Asp Ser Ala Thr Pro Asp 
    130                 135                 140                 


Asp Thr Ser Asn Ser Ser Ser Val Asp Trp Asp Thr Val Glu Arg Gln 
145                 150                 155                 160 


Glu Glu Glu Ala Pro Ser Trp Asp Glu Leu Ala Val Met Ile Pro Arg 
                165                 170                 175     


Arg Pro Arg Glu Gly Pro Arg Ala Asp Ser Ser Gln Arg Ala Pro Ser 
            180                 185                 190         


Leu Leu Thr Arg Ser Pro Val Gly Gly Asp Ala Ala Gly Gln Lys Lys 
        195                 200                 205             


Glu Asp Thr Gly Gly Gly Gly Arg Ser Ala Gly Gln His Trp Ala Arg 
    210                 215                 220                 


Leu Arg Gly Glu Ser Gly Leu Ser Leu Glu Arg His Arg Ser Thr Leu 
225                 230                 235                 240 


Thr Gln Ala Ser Ser Met Thr Pro His Ser Gly Pro Arg Ser Thr Thr 
                245                 250                 255     


Ser Gln Ala Ser Pro Ala Gln Arg Asp Thr Ala Gln Ala Ala Ser Thr 
            260                 265                 270         


Arg Glu Ile Pro Arg Ala Ser Ser Pro His Arg Ile Thr Gln Arg Asp 
        275                 280                 285             


Thr Ser Arg Ala Ser Ser Thr Gln Gln Glu Ile Ser Arg Ala Ser Ser 
    290                 295                 300                 


Thr Gln Gln Glu Thr Ser Arg Ala Ser Ser Thr Gln Glu Asp Thr Pro 
305                 310                 315                 320 


Arg Ala Ser Ser Thr Gln Glu Asp Thr Pro Arg Ala Ser Ser Thr Gln 
                325                 330                 335     


Trp Asn Thr Pro Arg Ala Ser Ser Pro Ser Arg Ser Thr Gln Leu Asp 
            340                 345                 350         


Asn Pro Arg Thr Ser Ser Thr Gln Gln Asp Asn Pro Gln Thr Ser Phe 
        355                 360                 365             


Pro Thr Cys Thr Pro Gln Arg Glu Asn Pro Arg Thr Pro Cys Val Gln 
    370                 375                 380                 


Gln Asp Asp Pro Arg Ala Ser Ser Pro Asn Arg Thr Thr Gln Arg Glu 
385                 390                 395                 400 


Asn Ser Arg Thr Ser Cys Ala Gln Arg Asp Asn Pro Lys Ala Ser Arg 
                405                 410                 415     


Thr Ser Ser Pro Asn Arg Ala Thr Arg Asp Asn Pro Arg Thr Ser Cys 
            420                 425                 430         


Ala Gln Arg Asp Asn Pro Arg Ala Ser Ser Pro Ser Arg Ala Thr Arg 
        435                 440                 445             


Asp Asn Pro Thr Thr Ser Cys Ala Gln Arg Asp Asn Pro Arg Ala Ser 
    450                 455                 460                 


Arg Thr Ser Ser Pro Asn Arg Ala Thr Arg Asp Asn Pro Arg Thr Ser 
465                 470                 475                 480 


Cys Ala Gln Arg Asp Asn Pro Arg Ala Ser Ser Pro Ser Arg Ala Thr 
                485                 490                 495     


Arg Asp Asn Pro Thr Thr Ser Cys Ala Gln Arg Asp Asn Pro Arg Ala 
            500                 505                 510         


Ser Arg Thr Ser Ser Pro Asn Arg Ala Thr Arg Asp Asn Pro Arg Thr 
        515                 520                 525             


Ser Cys Ala Gln Arg Asp Asn Pro Arg Ala Ser Ser Pro Asn Arg Ala 
    530                 535                 540                 


Ala Arg Asp Asn Pro Thr Thr Ser Cys Ala Gln Arg Asp Asn Pro Arg 
545                 550                 555                 560 


Ala Ser Arg Thr Ser Ser Pro Asn Arg Ala Thr Arg Asp Asn Pro Arg 
                565                 570                 575     


Thr Ser Cys Ala Gln Arg Asp Asn Pro Arg Ala Ser Ser Pro Asn Arg 
            580                 585                 590         


Ala Thr Arg Asp Asn Pro Thr Thr Ser Cys Ala Gln Arg Asp Asn Pro 
        595                 600                 605             


Arg Ala Ser Arg Thr Ser Ser Pro Asn Arg Ala Thr Arg Asp Asn Pro 
    610                 615                 620                 


Arg Thr Ser Cys Ala Gln Arg Asp Asn Pro Arg Ala Ser Ser Pro Asn 
625                 630                 635                 640 


Arg Thr Thr Gln Gln Asp Ser Pro Arg Thr Ser Cys Ala Arg Arg Asp 
                645                 650                 655     


Asp Pro Arg Ala Ser Ser Pro Asn Arg Thr Ile Gln Gln Glu Asn Pro 
            660                 665                 670         


Arg Thr Ser Cys Ala Leu Arg Asp Asn Pro Arg Ala Ser Ser Pro Ser 
        675                 680                 685             


Arg Thr Ile Gln Gln Glu Asn Pro Arg Thr Ser Cys Ala Gln Arg Asp 
    690                 695                 700                 


Asp Pro Arg Ala Ser Ser Pro Asn Arg Thr Thr His Pro Pro His Thr 
705                 710                 715                 720 


His Thr His Thr His Thr His Thr Gln Thr His Arg His Ile Arg Thr 
                725                 730                 735     


His Val His Thr Cys Thr His Gly Tyr Thr His Thr His Thr His Cys 
            740                 745                 750         


Ile Ser Glu Arg Ala Pro Arg Thr Gly Ser His Leu Ala Pro Ser Ser 
        755                 760                 765             


Gly Phe Tyr Met 
    770         

<210>  3635
<211>  707
<212>  DNA
<213>  Homo sapiens

<400>  3635
caccacacct gggctaattt ttgtattttt agagactagg tttcactatg ttgtctaggc     60

tggtcttgaa ctcctgagct caagccatcc gcctgcctca gcctcccaaa gttctgggat    120

tacaggcgtg acccattgcg ccctgcccaa tcccatactt ttgaaggtgt cgttccagca    180

tggctcctca ggcacaggcc caccacagac agcagggcct atggaggcct gagcagagtt    240

tcctcatact tccctttttg tgcactccag cctgggtgac agagcgagac tccatctcaa    300

aaaaaaaaaa aaaaaaaaga cacttgcttg gacagtttat gttggcctct ctgaagttgt    360

cagggagaat gtttctttct tctgatcttg ctcagagctc ttttgccaac agctaggatg    420

gcctggagtt ttcaaggcta agcgctggga ttctgttggt taacagtgat gggagggaaa    480

aaggaaaaga aatccaaaat ttacaatatg gacaggaaaa ggcagaaaga atggaacacg    540

ggggcacaca gcagtctggc tctgtcgtcc cacctcgtgg gctgcgatca tgatacaagt    600

gcttggcccc tggaacataa gaagcactca ataaatgctt tgtcataatg attatgtgtg    660

cccagtgcct ggtacacagt aggtgctcaa taaatcttaa ttcccgc                  707


<210>  3636
<211>  78
<212>  PRT
<213>  Homo sapiens

<400>  3636


Met Ala Pro Gln Ala Gln Ala His His Arg Gln Gln Gly Leu Trp Arg 
1               5                   10                  15      


Pro Glu Gln Ser Phe Leu Ile Leu Pro Phe Leu Cys Thr Pro Ala Trp 
            20                  25                  30          


Val Thr Glu Arg Asp Ser Ile Ser Lys Lys Lys Lys Lys Lys Arg His 
        35                  40                  45              


Leu Leu Gly Gln Phe Met Leu Ala Ser Leu Lys Leu Ser Gly Arg Met 
    50                  55                  60                  


Phe Leu Ser Ser Asp Leu Ala Gln Ser Ser Phe Ala Asn Ser 
65                  70                  75              

<210>  3637
<211>  423
<212>  DNA
<213>  Homo sapiens

<400>  3637
ataaagaaat ggaggcccag ggagctgaag ttctttccca gcatttgctg ccaggagtct     60

ctccaccatg aggaatgagg ccaaggcagt cagtccttgg gagagtgaat gaacacgcag    120

gagacctcac ctaccaccag ggtcctggtc cagtgccctg ggcacctaac agcaccagcc    180

tcctccaggc ttttctggcc cctgcgactc ctcctagtac ccgcaacaca gtgaccagac    240

cacttccctg ctcaaagttc ttccacacat caccaatgct gacagatcag tgctacattc    300

ctcttctagg cagtcaggaa ccatcacaac ctggctcctg cctgtcatcc tggccttcca    360

gattctcatt tgacaggctg gagagacaca tactttggtc aattttgcaa aatacaataa    420

gta                                                                  423


<210>  3638
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  3638


Met Arg Pro Arg Gln Ser Val Leu Gly Arg Val Asn Glu His Ala Gly 
1               5                   10                  15      


Asp Leu Thr Tyr His Gln Gly Pro Gly Pro Val Pro Trp Ala Pro Asn 
            20                  25                  30          


Ser Thr Ser Leu Leu Gln Ala Phe Leu Ala Pro Ala Thr Pro Pro Ser 
        35                  40                  45              


Thr Arg Asn Thr Val Thr Arg Pro Leu Pro Cys Ser Lys Phe Phe His 
    50                  55                  60                  


Thr Ser Pro Met Leu Thr Asp Gln Cys Tyr Ile Pro Leu Leu Gly Ser 
65                  70                  75                  80  


Gln Glu Pro Ser Gln Pro Gly Ser Cys Leu Ser Ser Trp Pro Ser Arg 
                85                  90                  95      


Phe Ser Phe Asp Arg Leu Glu Arg His Ile Leu Trp Ser Ile Leu Gln 
            100                 105                 110         


Asn Thr Ile 
        115 

<210>  3639
<211>  771
<212>  DNA
<213>  Homo sapiens

<400>  3639
gggcccagca gcagcacaag ccagcttcct cccctccggc ctcagtcctc ttacctctcc     60

aggctcgtcc aagatcgaca tccatccctt cttgaagttg agcagatcgg gctgtgggga    120

gatgaggagg gagagatggg gtctccctat gtttcccagg ttggtttcaa actcctgagc    180

tcaagtgatc cgctcacctc ggcctccaaa aatgctggga ttataggtgt gagccaatgt    240

gcccggccaa ccaatgtgtg ggcgtgcacc cgttgctcag gttcccagaa cgctgggccg    300

tttgttagat gctcttttcc tgcagataaa gaaatggagg cccagggagc tgaagttctt    360

tcccagcatt tgctgccagg agtctctcca ccatgaggaa tgaggccaag gttaagtcca    420

tctaactcta gaaactggcc ttctggcacc ccgggctgag ttttctcacc ctacccttgc    480

acctcactca ggcagtcagt ccttgggaga gtgaatgaac acgcaggaga cctcacctac    540

caccagggtc ctggtccagt gccctgggca cctaacagca ccagcctcct ccaggctttt    600

ctggcccctg cgactcctcc tagtacccgc aacacagtga ccagaccact tccctgctca    660

aagttcttcc acacatcacc aatgctgaca gatcagtgct acattcctct tctaggcagt    720

caggaaccat cacaacctgg ctcctgcctg tcatcctggc cttccagatt c             771


<210>  3640
<211>  86
<212>  PRT
<213>  Homo sapiens

<400>  3640


Met Gly Ser Pro Tyr Val Ser Gln Val Gly Phe Lys Leu Leu Ser Ser 
1               5                   10                  15      


Ser Asp Pro Leu Thr Ser Ala Ser Lys Asn Ala Gly Ile Ile Gly Val 
            20                  25                  30          


Ser Gln Cys Ala Arg Pro Thr Asn Val Trp Ala Cys Thr Arg Cys Ser 
        35                  40                  45              


Gly Ser Gln Asn Ala Gly Pro Phe Val Arg Cys Ser Phe Pro Ala Asp 
    50                  55                  60                  


Lys Glu Met Glu Ala Gln Gly Ala Glu Val Leu Ser Gln His Leu Leu 
65                  70                  75                  80  


Pro Gly Val Ser Pro Pro 
                85      

<210>  3641
<211>  624
<212>  DNA
<213>  Homo sapiens

<400>  3641
cgattttcgt cctcaccaca gacttgggag ggaggtctta ttttgctaat gagaaaacgg     60

aggctcagag gggtgagccg atttgcccga ggtcacacag gaagaggcgg aattcctagc    120

gagtaagctg gacacaaagt gtgggcgtgc acccgttgct caggttccca gaacgctggg    180

ccgtttgtta gatgctcttt tcctgcagat aaagaaatgg aggcccaggg agctgaagtt    240

ctttcccagc atttgctgcc aggagtctct ccaccatgag gaatgaggcc aaggttaagt    300

ccatctaact ctagaaactg gccttctggc accccgggct gagttttctc accctaccct    360

tgcacctcac tcaggcagtc agtccttggg agagtgaatg aacacgcagg agacctcacc    420

taccaccagg gtcctggtcc agtgccctgg gcacctaaca gcaccagcct cctccaggct    480

tttctggccc ctgcgactcc tcctagtacc cgcaacacag tgaccagacc acttccctgc    540

tcaaagttct tccacacatc accaatgctg acagatcagt gctacattcc tcttctaggc    600

agtcaggaac catcacaacc tggc                                           624


<210>  3642
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  3642


Met Asn Thr Gln Glu Thr Ser Pro Thr Thr Arg Val Leu Val Gln Cys 
1               5                   10                  15      


Pro Gly His Leu Thr Ala Pro Ala Ser Ser Arg Leu Phe Trp Pro Leu 
            20                  25                  30          


Arg Leu Leu Leu Val Pro Ala Thr Gln 
        35                  40      

<210>  3643
<211>  1733
<212>  DNA
<213>  Homo sapiens

<400>  3643
aaaaagtttt atgggcggat ggaaggggcc ggggcagcgt cggggaaagg aagggccgga     60

ggcgcggcgg cgggcggccg agaggggcgg cggcggcggc ggcggcgggg ttcccgcgcc    120

gcggagcccg gcccgagagc cgcgtccacg ttcctgcctc ctgctcccgc cgccctgggg    180

cgccgccatg acgcccgatc tgctcaactt caagaaggga tggatgtcga tcttggacga    240

gcctggagag cctccctccc cctcgctcac caccacctct acttcgcagt ggaagaaaca    300

ttggtttgtg ctgacagatt caagtctcaa atattacaga gactccactg ctgaggaggc    360

agatgagctg gatggtgaga tcgacctgcg ttcctgcacg gatgtcactg agtacgcggt    420

gcagcgcaac tatggcttcc agatccacac caaggatgct gtctatacct tgtcggccat    480

gacctcaggc atccggcgga actggatcga ggctctgaga aagaccgtac gtccaacttc    540

agccccagat gtcaccaagc tctcggactc taacaaggag aacgcgctgc acagctacag    600

cacccagaag ggccccctga aggcagggga gcagcgggcg ggctctgagg tcatcagccg    660

gggtggccct cggaaggcgg acgggcagcg tcaggccttg gactacgtgg agctctcgcc    720

gctgacccag gcttccccgc agcgggcccg caccccagcc cgcactcctg accgcctggc    780

caagcaggag gagctggagc gggacctggc ccagcgctcc gaggagcggc gcaagtggtt    840

tgaggccaca gacagcagga ccccagaggt gcctgctggt gaggggccgc gccggggcct    900

gggtgccccc ctgactgagg accagcaaaa ccggcttagt gaggagatcg agaagaagtg    960

gcaggagctg gagaagctgc ccctgcggga gaataagcgg gtgcccctca ctgccctgct   1020

caaccaaagc cgcggagagc gccgagggcc cccaagtgac ggccacgagg cactggagaa   1080

ggaggttcag gctcttcggg cccagctgga ggcgtggcgt ctccaagggg aggctcctca   1140

gagtgcactg agatcccagg aggatggcca catccccccg ggctacatct cacagctggt   1200

gggcgtgatc actgtgcccg ttttacagac aaggccactg agctctgaga ggttatgtga   1260

cttgcccaag gtcaccccgc ctgcaggtct caaaggtggg atttgagcga gggtccggct   1320

gactgcagag cctgtgtgtg agtccccgtg tgacactctg cacttggacc cttgccccgg   1380

ggaagtgggg ggctagtggc cccgagagtc actccctgaa cacagggaaa tcctgccgag   1440

gcccactggg ccaaggcccc acacaaggag gtctgcagga caggggagcc tccagtagcc   1500

ctcagagaat gcaccgtccg cctaggacag cggttctcaa cggggtccat tttgtccccc   1560

ttggggacat ttggctgtgt ctgggaatac ttctggttgt cacaactagg acaaactaac   1620

tctctagaaa aaacgtgtgt gtgtacacat atataagttt attataaatt ttaccaataa   1680

aaacaatgct tagtacacaa tttacaaata aaaatatata attttattgt gaa          1733


<210>  3644
<211>  431
<212>  PRT
<213>  Homo sapiens

<400>  3644


Met Gly Gly Trp Lys Gly Pro Gly Gln Arg Arg Gly Lys Glu Gly Pro 
1               5                   10                  15      


Glu Ala Arg Arg Arg Ala Ala Glu Arg Gly Gly Gly Gly Gly Gly Gly 
            20                  25                  30          


Gly Val Pro Ala Pro Arg Ser Pro Ala Arg Glu Pro Arg Pro Arg Ser 
        35                  40                  45              


Cys Leu Leu Leu Pro Pro Pro Trp Gly Ala Ala Met Thr Pro Asp Leu 
    50                  55                  60                  


Leu Asn Phe Lys Lys Gly Trp Met Ser Ile Leu Asp Glu Pro Gly Glu 
65                  70                  75                  80  


Pro Pro Ser Pro Ser Leu Thr Thr Thr Ser Thr Ser Gln Trp Lys Lys 
                85                  90                  95      


His Trp Phe Val Leu Thr Asp Ser Ser Leu Lys Tyr Tyr Arg Asp Ser 
            100                 105                 110         


Thr Ala Glu Glu Ala Asp Glu Leu Asp Gly Glu Ile Asp Leu Arg Ser 
        115                 120                 125             


Cys Thr Asp Val Thr Glu Tyr Ala Val Gln Arg Asn Tyr Gly Phe Gln 
    130                 135                 140                 


Ile His Thr Lys Asp Ala Val Tyr Thr Leu Ser Ala Met Thr Ser Gly 
145                 150                 155                 160 


Ile Arg Arg Asn Trp Ile Glu Ala Leu Arg Lys Thr Val Arg Pro Thr 
                165                 170                 175     


Ser Ala Pro Asp Val Thr Lys Leu Ser Asp Ser Asn Lys Glu Asn Ala 
            180                 185                 190         


Leu His Ser Tyr Ser Thr Gln Lys Gly Pro Leu Lys Ala Gly Glu Gln 
        195                 200                 205             


Arg Ala Gly Ser Glu Val Ile Ser Arg Gly Gly Pro Arg Lys Ala Asp 
    210                 215                 220                 


Gly Gln Arg Gln Ala Leu Asp Tyr Val Glu Leu Ser Pro Leu Thr Gln 
225                 230                 235                 240 


Ala Ser Pro Gln Arg Ala Arg Thr Pro Ala Arg Thr Pro Asp Arg Leu 
                245                 250                 255     


Ala Lys Gln Glu Glu Leu Glu Arg Asp Leu Ala Gln Arg Ser Glu Glu 
            260                 265                 270         


Arg Arg Lys Trp Phe Glu Ala Thr Asp Ser Arg Thr Pro Glu Val Pro 
        275                 280                 285             


Ala Gly Glu Gly Pro Arg Arg Gly Leu Gly Ala Pro Leu Thr Glu Asp 
    290                 295                 300                 


Gln Gln Asn Arg Leu Ser Glu Glu Ile Glu Lys Lys Trp Gln Glu Leu 
305                 310                 315                 320 


Glu Lys Leu Pro Leu Arg Glu Asn Lys Arg Val Pro Leu Thr Ala Leu 
                325                 330                 335     


Leu Asn Gln Ser Arg Gly Glu Arg Arg Gly Pro Pro Ser Asp Gly His 
            340                 345                 350         


Glu Ala Leu Glu Lys Glu Val Gln Ala Leu Arg Ala Gln Leu Glu Ala 
        355                 360                 365             


Trp Arg Leu Gln Gly Glu Ala Pro Gln Ser Ala Leu Arg Ser Gln Glu 
    370                 375                 380                 


Asp Gly His Ile Pro Pro Gly Tyr Ile Ser Gln Leu Val Gly Val Ile 
385                 390                 395                 400 


Thr Val Pro Val Leu Gln Thr Arg Pro Leu Ser Ser Glu Arg Leu Cys 
                405                 410                 415     


Asp Leu Pro Lys Val Thr Pro Pro Ala Gly Leu Lys Gly Gly Ile 
            420                 425                 430     

<210>  3645
<211>  2699
<212>  DNA
<213>  Homo sapiens

<400>  3645
aaaaagtttt atgggcggat ggaaggggcc ggggcagcgt cggggaaagg aagggccgga     60

ggcgcggcgg cgggcggccg agaggggcgg cggcggcggc ggcggcgggg ttcccgcgcc    120

gcggagcccg gcccgagagc cgcgtccacg ttcctgcctc ctgctcccgc cgccctgggg    180

cgccgccatg acgcccgatc tgctcaactt caagaaggga tggatgtcga tcttggacga    240

gcctggagag cctccctccc cctcgctcac caccacctct acttcgcagt ggaagaaaca    300

ttggtttgtg ctgacagatt caagtctcaa atattacaga gactccactg ctgaggaggc    360

agatgagctg gatggtgaga tcgacctgcg ttcctgcacg gatgtcactg agtacgcggt    420

gcagcgcaac tatggcttcc agatccacac caaggatgct gtctatacct tgtcggccat    480

gacctcaggc atccggcgga actggatcga ggctctgaga aagaccgtac gtccaacttc    540

agccccagat gtcaccaagc tctcggactc taacaaggag aacgcgctgc acagctacag    600

cacccagaag ggccccctga aggcagggga gcagcgggcg ggctctgagg tcatcagccg    660

gggtggccct cggaaggcgg acgggcagcg tcaggccttg gactacgtgg agctctcgcc    720

gctgacccag gcttccccgc agcgggcccg caccccagcc cgcactcctg accgcctggc    780

caagcaggag gagctggagc gggacctggc ccagcgctcc gaggagcggc gcaagtggtt    840

tgaggccaca gacagcagga ccccagaggt gcctgctggt gaggggccgc gccggggcct    900

gggtgccccc ctgactgagg accagcaaaa ccggcttagt gaggagatcg agaagaagtg    960

gcaggagctg gagaagctgc ccctgcggga gaataagcgg gtgcccctca ctgccctgct   1020

caaccaaagc cgcggagagc gccgagggcc cccaagtgac ggccacgagg cactggagaa   1080

ggaggttcag gctcttcggg cccagctgga ggcgtggcgt ctccaagggg aggctcctca   1140

gagtgcactg agatcccagg aggatggcca catccccccg ggctacatct cacaggaggc   1200

atgtgagcgc agcctggcag agatggagtc ctcgcaccag caggtgatgg aggagctgca   1260

gcggcaccac gagcgggagc tgcagcgcct gcagcaggag aaggagtggc tcctggctga   1320

ggagacggca gccacggcct cagccattga agccatgaag aaggcctacc aggaagagct   1380

gagccgagag ctgagcaaaa cacggagtct ccagcagggc ccggatggcc tccggaagca   1440

gcaccagtca gatgtggagg cactgaagcg agagctgcag gtgctatcgg agcagtactc   1500

gcagaagtgc ctggagattg gggcactcat gcggcaggct gaggagcgcg agcacacgct   1560

gcgccgctgc cagcaggagg gccaggagct gctgcgccac aaccaggagc tgcatggccg   1620

cctgtcagag gagatagacc agctgcgcgg cttcattgcc tcgcagggca tgggcaatgg   1680

ctgcgggcgc agcaacgagc ggagttcctg cgagctagag gtgctgcttc gcgtaaaaga   1740

aaacgaactc cagtacctaa agaaggaggt gcagtgcctc cgggacgagc tccagatgat   1800

gcagaaggac aagcgcttca cctcgggaaa gtaccaggac gtctatgtgg agctgagcca   1860

catcaagaca cggtctgagc gggagatcga gcagctgaag gagcacctgc gtcttgccat   1920

ggccgccctc caggagaagg agtcgatgcg caacagcctg gctgagtaga ggtcccgccc   1980

agctgcagac cctccaggct ggaggaccag ccgccctcct tccctcctgg atggaagtaa   2040

aaagccaagc tttctcccca ccctctgtgg gccacacgtg cacttgcacc caccacacac   2100

acacacacac acacacacac acacacagac acacagacac atacgcacac acgtgcacac   2160

atgtacacac ggatacacac acacacacac acactgcata tctgagcgcg cccctcgcac   2220

tgggtctcac cttgcacctt cttcaggatt ttatatgtga agagattttt atatagattt   2280

ttttcctttt tttccaaaac actttatact ttaaaaaaaa aaaaaaaaag caattcctgg   2340

tggctgtgtg cctccaaccc tggtccccct ctgtctccag ccaccctctg cttgggcttc   2400

tgagctggtg gccctggccc agaggtctgg cggaggccca ggcagcagcc atggcggggt   2460

gtctctacag gggagaggcg ggagcctgcc accctcttcc tgccctacct cctactaaca   2520

cttcctgccc catttggacc cgtaccatgg ggctcaggac agagggagct agcagctggc   2580

ctccatggcc ccacagcctc cttcgaggct gtgctgggtg cagaaccgcc agagccaccc   2640

aaaaggtgtt tctcttctgc tccctgaacc tcttaactta ataaaacgtt ccagcagct    2699


<210>  3646
<211>  652
<212>  PRT
<213>  Homo sapiens

<400>  3646


Met Gly Gly Trp Lys Gly Pro Gly Gln Arg Arg Gly Lys Glu Gly Pro 
1               5                   10                  15      


Glu Ala Arg Arg Arg Ala Ala Glu Arg Gly Gly Gly Gly Gly Gly Gly 
            20                  25                  30          


Gly Val Pro Ala Pro Arg Ser Pro Ala Arg Glu Pro Arg Pro Arg Ser 
        35                  40                  45              


Cys Leu Leu Leu Pro Pro Pro Trp Gly Ala Ala Met Thr Pro Asp Leu 
    50                  55                  60                  


Leu Asn Phe Lys Lys Gly Trp Met Ser Ile Leu Asp Glu Pro Gly Glu 
65                  70                  75                  80  


Pro Pro Ser Pro Ser Leu Thr Thr Thr Ser Thr Ser Gln Trp Lys Lys 
                85                  90                  95      


His Trp Phe Val Leu Thr Asp Ser Ser Leu Lys Tyr Tyr Arg Asp Ser 
            100                 105                 110         


Thr Ala Glu Glu Ala Asp Glu Leu Asp Gly Glu Ile Asp Leu Arg Ser 
        115                 120                 125             


Cys Thr Asp Val Thr Glu Tyr Ala Val Gln Arg Asn Tyr Gly Phe Gln 
    130                 135                 140                 


Ile His Thr Lys Asp Ala Val Tyr Thr Leu Ser Ala Met Thr Ser Gly 
145                 150                 155                 160 


Ile Arg Arg Asn Trp Ile Glu Ala Leu Arg Lys Thr Val Arg Pro Thr 
                165                 170                 175     


Ser Ala Pro Asp Val Thr Lys Leu Ser Asp Ser Asn Lys Glu Asn Ala 
            180                 185                 190         


Leu His Ser Tyr Ser Thr Gln Lys Gly Pro Leu Lys Ala Gly Glu Gln 
        195                 200                 205             


Arg Ala Gly Ser Glu Val Ile Ser Arg Gly Gly Pro Arg Lys Ala Asp 
    210                 215                 220                 


Gly Gln Arg Gln Ala Leu Asp Tyr Val Glu Leu Ser Pro Leu Thr Gln 
225                 230                 235                 240 


Ala Ser Pro Gln Arg Ala Arg Thr Pro Ala Arg Thr Pro Asp Arg Leu 
                245                 250                 255     


Ala Lys Gln Glu Glu Leu Glu Arg Asp Leu Ala Gln Arg Ser Glu Glu 
            260                 265                 270         


Arg Arg Lys Trp Phe Glu Ala Thr Asp Ser Arg Thr Pro Glu Val Pro 
        275                 280                 285             


Ala Gly Glu Gly Pro Arg Arg Gly Leu Gly Ala Pro Leu Thr Glu Asp 
    290                 295                 300                 


Gln Gln Asn Arg Leu Ser Glu Glu Ile Glu Lys Lys Trp Gln Glu Leu 
305                 310                 315                 320 


Glu Lys Leu Pro Leu Arg Glu Asn Lys Arg Val Pro Leu Thr Ala Leu 
                325                 330                 335     


Leu Asn Gln Ser Arg Gly Glu Arg Arg Gly Pro Pro Ser Asp Gly His 
            340                 345                 350         


Glu Ala Leu Glu Lys Glu Val Gln Ala Leu Arg Ala Gln Leu Glu Ala 
        355                 360                 365             


Trp Arg Leu Gln Gly Glu Ala Pro Gln Ser Ala Leu Arg Ser Gln Glu 
    370                 375                 380                 


Asp Gly His Ile Pro Pro Gly Tyr Ile Ser Gln Glu Ala Cys Glu Arg 
385                 390                 395                 400 


Ser Leu Ala Glu Met Glu Ser Ser His Gln Gln Val Met Glu Glu Leu 
                405                 410                 415     


Gln Arg His His Glu Arg Glu Leu Gln Arg Leu Gln Gln Glu Lys Glu 
            420                 425                 430         


Trp Leu Leu Ala Glu Glu Thr Ala Ala Thr Ala Ser Ala Ile Glu Ala 
        435                 440                 445             


Met Lys Lys Ala Tyr Gln Glu Glu Leu Ser Arg Glu Leu Ser Lys Thr 
    450                 455                 460                 


Arg Ser Leu Gln Gln Gly Pro Asp Gly Leu Arg Lys Gln His Gln Ser 
465                 470                 475                 480 


Asp Val Glu Ala Leu Lys Arg Glu Leu Gln Val Leu Ser Glu Gln Tyr 
                485                 490                 495     


Ser Gln Lys Cys Leu Glu Ile Gly Ala Leu Met Arg Gln Ala Glu Glu 
            500                 505                 510         


Arg Glu His Thr Leu Arg Arg Cys Gln Gln Glu Gly Gln Glu Leu Leu 
        515                 520                 525             


Arg His Asn Gln Glu Leu His Gly Arg Leu Ser Glu Glu Ile Asp Gln 
    530                 535                 540                 


Leu Arg Gly Phe Ile Ala Ser Gln Gly Met Gly Asn Gly Cys Gly Arg 
545                 550                 555                 560 


Ser Asn Glu Arg Ser Ser Cys Glu Leu Glu Val Leu Leu Arg Val Lys 
                565                 570                 575     


Glu Asn Glu Leu Gln Tyr Leu Lys Lys Glu Val Gln Cys Leu Arg Asp 
            580                 585                 590         


Glu Leu Gln Met Met Gln Lys Asp Lys Arg Phe Thr Ser Gly Lys Tyr 
        595                 600                 605             


Gln Asp Val Tyr Val Glu Leu Ser His Ile Lys Thr Arg Ser Glu Arg 
    610                 615                 620                 


Glu Ile Glu Gln Leu Lys Glu His Leu Arg Leu Ala Met Ala Ala Leu 
625                 630                 635                 640 


Gln Glu Lys Glu Ser Met Arg Asn Ser Leu Ala Glu 
                645                 650         

<210>  3647
<211>  4744
<212>  DNA
<213>  Homo sapiens

<400>  3647
aaaaagtttt atgggcggat ggaaggggcc ggggcagcgt cggggaaagg aagggccgga     60

ggcgcggcgg cgggcggccg agaggggcgg cggcggcggc ggcggcgggg ttcccgcgcc    120

gcggagcccg gcccgagagc cgcgtccacg ttcctgcctc ctgctcccgc cgccctgggg    180

cgccgccatg acgcccgatc tgctcaactt caagaaggga tggatgtcga tcttggacga    240

gcctggagag cctccctccc cctcgctcac caccacctct acttcgcagt ggaagaaaca    300

ttggtttgtg ctgacagatt caagtctcaa atattacaga gactccactg ctgaggaggc    360

agatgagctg gatggtgaga tcgacctgcg ttcctgcacg gatgtcactg agtacgcggt    420

gcagcgcaac tatggcttcc agatccacac caaggatgct gtctatacct tgtcggccat    480

gacctcaggc atccggcgga actggatcga ggctctgaga aagaccgtac gtccaacttc    540

agccccagat gtcaccaagc tctcggactc taacaaggag aacgcgctgc acagctacag    600

cacccagaag ggccccctga aggcagggga gcagcgggcg ggctctgagg tcatcagccg    660

gggtggccct cggaaggcgg acgggcagcg tcaggccttg gactacgtgg agctctcgcc    720

gctgacccag gcttccccgc agcgggcccg caccccagcc cgcactcctg accgcctggc    780

caagcaggag gagctggagc gggacctggc ccagcgctcc gaggagcggc gcaagtggtt    840

tgaggccaca gacagcagga ccccagaggt gcctgctggt gaggggccgc gccggggcct    900

gggtgccccc ctgactgagg accagcaaaa ccggcttagt gaggagatcg agaagaagtg    960

gcaggagctg gagaagctgc ccctgcggga gaataagcgg gtgcccctca ctgccctgct   1020

caaccaaagc cgcggagagc gccgagggcc cccaagtgac ggccacgagg cactggagaa   1080

ggaggttcag gctcttcggg cccagctgga ggcgtggcgt ctccaagggg aggctcctca   1140

gagtgcactg agatcccagg aggatggcca catccccccg ggctacatct cacaggaggc   1200

atgtgagcgc agcctggcag agatggagtc ctcgcaccag caggtgatgg aggagctgca   1260

gcggcaccac gagcgggagc tgcagcgcct gcagcaggag aaggagtggc tcctggctga   1320

ggagacggca gccacggcct cagccattga agccatgaag aaggcctacc aggaagagct   1380

gagccgagag ctgagcaaaa cacggagtct ccagcagggc ccggatggcc tccggaagca   1440

gcaccagtca gatgtggagg cactgaagcg agagctgcag gtgctatcgg agcagtactc   1500

gcagaagtgc ctggagattg gggcactcat gcggcaggct gaggagcgcg agcacacgct   1560

gcgccgctgc cagcaggagg gccaggagct gctgcgccac aaccaggagc tgcatggccg   1620

cctgtcagag gagatagacc agctgcgcgg cttcattgcc tcgcagggca tgggcaatgg   1680

ctgcgggcgc agcaacgagc ggagttcctg cgagctagag gtgctgcttc gcgtaaaaga   1740

aaacgaactc cagtacctaa agaaggaggt gcagtgcctc cgggacgagc tccagatgat   1800

gcagaaggac aagcgcttca cctcgggaaa gtaccaggac gtctatgtgg agctgagcca   1860

catcaagaca cggtctgagc gggagatcga gcagctgaag gagcacctgc gtcttgccat   1920

ggccgccctc caggagaagg agtcgatgcg caacagcctg gctgagtaga ggtcccgccc   1980

agctgcagac cctccaggct ggaggaccag ccgccctcct tccctcctgg atggaagtaa   2040

aaagccaagc tttctcccca ccctctgtgg gccacacgtg cacttgcacc caccacacac   2100

acacacacac acacacacac acacacagac acacagacac atacgcacac acgtgcacac   2160

atgtacacac ggatacacac acacacacac acactgcata tctgagcgcg cccctcgcac   2220

tgggtctcac cttgcacctt cttcaggatt ttatatgtga agagattttt atatagattt   2280

ttttcctttt tttccaaaac actttatact ttaaaaaaaa aaaaaaaaag caattcctgg   2340

tggctgtgtg cctccaaccc tggtccccct ctgtctccag ccaccctctg cttgggcttc   2400

tgagctggtg gccctggccc agaggtctgg cggaggccca ggcagcagcc atggcggggt   2460

gtctctacag gggagaggcg ggagcctgcc accctcttcc tgccctacct cctactaaca   2520

cttcctgccc catttggacc cgtaccatgg ggctcaggac agagggagct agcagctggc   2580

ctccatggcc ccacagcctc cttcgaggct gtgctgggtg cagaaccgcc agagccaccc   2640

aaaaggtgtt tctcttctgc tccctgaacc tcttaactta ataaaacgtt ccagcagctc   2700

tggtgtccta gatggctggc agaacaggaa tggagattgg ggtttcttga agtggcttcc   2760

ccactcacac cctacccaca ccccaccctt cctaaagcag cggcctctag gcttctgagg   2820

gtggggctga aaatccaagg tctcccttag tacagactgt gacgccccca gtgtggcttg   2880

caggctagtg gcagcggaag catgtgggaa atagcaagtc cagtcccacc ccaacctact   2940

gaaccagcgt ctgcatttta acagggtgcc ccagtgattc acgtgacctt caaagtctga   3000

ggagccctgg agtagggccc agggcccagg cctgagagag aggcctgggg ctaagactag   3060

ccctgaccat gaccttgggc aagtcacacc cctcactgag cctcagtttg cttctccatc   3120

aaatgggtgt ttttctttca gtcccagtcc tctcctgagg cttttcccag aggtcatgcc   3180

cagccctggg caggggtgag ggcagggttg tggctgccag gcacaggtcc agcgggctgg   3240

gagtcctcac catggctggc tgtgctgatt atggttgcat ggggctggga agaggtccca   3300

tttctgagcc acagaaacag gccacatcca gtaggggtcc tggaaggctg tgagaaccca   3360

gaggagaccc tgacccagcc tgcaggtaga agactgcctt tggaggcagc tttgaaagat   3420

gactcttcca gatggaagaa tcaggaaggg ccttcccacg tggaggcacc agcaggagca   3480

aacgtccctg gtgtgttcag gcaaagagcc acaggagagt gacctcgtgg agtgggaaga   3540

gattgtttcc cattcccttg ccagggattg gttgaggaat ggacaaggct tgcagttcac   3600

gcaagccagt gaaatgcgag gggaagtctt gggagtgggg tggaggaggt catctgggaa   3660

gggtgtcctt ggtcttaaaa agaggcacaa gaggccgggc gcggtggctc ttgcctatta   3720

tcctagcact ttgggaggcc aaggcagggg gatcacttga ggtcaggagt tcgagaccag   3780

cctggccaac atggtgaaac cccgtctcta ctaaaaatac aaaaaattag ccagacgtgg   3840

tgccaagcac ctgtaatccc agctactcag gaggctgagg caggagaatc acttgaaccc   3900

aggaggcaga agttgcagtg agccaagatc gcgccactgc actccagcct gtgtgacaag   3960

ggcgaaactc catctcaaaa aaaaaggggg agggtggcgc aaggagagga cacctctctc   4020

ctggccctgt cgccatcttc cctcatcaat agctaaaaat ggcaaagaag aaagagccag   4080

gaccccgtgc catcaaatcc tccggccttg tgctgccctg tctcggcact gcttgcctta   4140

ggagatcagg agtgttccta gccactggga gatgggatgc ctgccactgg cagctctgcc   4200

gtccatcctc accatcccac cgtcccccca agacagctct ccatcccatc ctctgcctcc   4260

cttctagcct caacctaact cagggctccc ccgtctcaca cctgggttgc aggaacatcc   4320

tcttcaccaa cccccctccc atccctcctc agggctgcct agggcagcta caaaaaccag   4380

gccagcctct gaaaggtgct ccacatctca ttaaaaaccg tgaaatcgca ctgccccact   4440

atcagaatag ctcagaggag aaggtctgcc agtaccaagt gctggtgggg atacggagaa   4500

gagcagctcc caggcgctgc tggtgcaaat gtgctttgtt gcacccacgg caggaaactg   4560

accagcttct catcaagtta aatacgcatc taccctatgg cctagcattt ccactcttgc   4620

ttacacatcc aggagaaatg agtccttaca tgcacaaaag gatgagtacc gtaatactca   4680

catcagcaaa taaacaatac agctgtgtgt cagtagtaga atgaataaat tgtggtcgat   4740

tcat                                                                4744


<210>  3648
<211>  652
<212>  PRT
<213>  Homo sapiens

<400>  3648


Met Gly Gly Trp Lys Gly Pro Gly Gln Arg Arg Gly Lys Glu Gly Pro 
1               5                   10                  15      


Glu Ala Arg Arg Arg Ala Ala Glu Arg Gly Gly Gly Gly Gly Gly Gly 
            20                  25                  30          


Gly Val Pro Ala Pro Arg Ser Pro Ala Arg Glu Pro Arg Pro Arg Ser 
        35                  40                  45              


Cys Leu Leu Leu Pro Pro Pro Trp Gly Ala Ala Met Thr Pro Asp Leu 
    50                  55                  60                  


Leu Asn Phe Lys Lys Gly Trp Met Ser Ile Leu Asp Glu Pro Gly Glu 
65                  70                  75                  80  


Pro Pro Ser Pro Ser Leu Thr Thr Thr Ser Thr Ser Gln Trp Lys Lys 
                85                  90                  95      


His Trp Phe Val Leu Thr Asp Ser Ser Leu Lys Tyr Tyr Arg Asp Ser 
            100                 105                 110         


Thr Ala Glu Glu Ala Asp Glu Leu Asp Gly Glu Ile Asp Leu Arg Ser 
        115                 120                 125             


Cys Thr Asp Val Thr Glu Tyr Ala Val Gln Arg Asn Tyr Gly Phe Gln 
    130                 135                 140                 


Ile His Thr Lys Asp Ala Val Tyr Thr Leu Ser Ala Met Thr Ser Gly 
145                 150                 155                 160 


Ile Arg Arg Asn Trp Ile Glu Ala Leu Arg Lys Thr Val Arg Pro Thr 
                165                 170                 175     


Ser Ala Pro Asp Val Thr Lys Leu Ser Asp Ser Asn Lys Glu Asn Ala 
            180                 185                 190         


Leu His Ser Tyr Ser Thr Gln Lys Gly Pro Leu Lys Ala Gly Glu Gln 
        195                 200                 205             


Arg Ala Gly Ser Glu Val Ile Ser Arg Gly Gly Pro Arg Lys Ala Asp 
    210                 215                 220                 


Gly Gln Arg Gln Ala Leu Asp Tyr Val Glu Leu Ser Pro Leu Thr Gln 
225                 230                 235                 240 


Ala Ser Pro Gln Arg Ala Arg Thr Pro Ala Arg Thr Pro Asp Arg Leu 
                245                 250                 255     


Ala Lys Gln Glu Glu Leu Glu Arg Asp Leu Ala Gln Arg Ser Glu Glu 
            260                 265                 270         


Arg Arg Lys Trp Phe Glu Ala Thr Asp Ser Arg Thr Pro Glu Val Pro 
        275                 280                 285             


Ala Gly Glu Gly Pro Arg Arg Gly Leu Gly Ala Pro Leu Thr Glu Asp 
    290                 295                 300                 


Gln Gln Asn Arg Leu Ser Glu Glu Ile Glu Lys Lys Trp Gln Glu Leu 
305                 310                 315                 320 


Glu Lys Leu Pro Leu Arg Glu Asn Lys Arg Val Pro Leu Thr Ala Leu 
                325                 330                 335     


Leu Asn Gln Ser Arg Gly Glu Arg Arg Gly Pro Pro Ser Asp Gly His 
            340                 345                 350         


Glu Ala Leu Glu Lys Glu Val Gln Ala Leu Arg Ala Gln Leu Glu Ala 
        355                 360                 365             


Trp Arg Leu Gln Gly Glu Ala Pro Gln Ser Ala Leu Arg Ser Gln Glu 
    370                 375                 380                 


Asp Gly His Ile Pro Pro Gly Tyr Ile Ser Gln Glu Ala Cys Glu Arg 
385                 390                 395                 400 


Ser Leu Ala Glu Met Glu Ser Ser His Gln Gln Val Met Glu Glu Leu 
                405                 410                 415     


Gln Arg His His Glu Arg Glu Leu Gln Arg Leu Gln Gln Glu Lys Glu 
            420                 425                 430         


Trp Leu Leu Ala Glu Glu Thr Ala Ala Thr Ala Ser Ala Ile Glu Ala 
        435                 440                 445             


Met Lys Lys Ala Tyr Gln Glu Glu Leu Ser Arg Glu Leu Ser Lys Thr 
    450                 455                 460                 


Arg Ser Leu Gln Gln Gly Pro Asp Gly Leu Arg Lys Gln His Gln Ser 
465                 470                 475                 480 


Asp Val Glu Ala Leu Lys Arg Glu Leu Gln Val Leu Ser Glu Gln Tyr 
                485                 490                 495     


Ser Gln Lys Cys Leu Glu Ile Gly Ala Leu Met Arg Gln Ala Glu Glu 
            500                 505                 510         


Arg Glu His Thr Leu Arg Arg Cys Gln Gln Glu Gly Gln Glu Leu Leu 
        515                 520                 525             


Arg His Asn Gln Glu Leu His Gly Arg Leu Ser Glu Glu Ile Asp Gln 
    530                 535                 540                 


Leu Arg Gly Phe Ile Ala Ser Gln Gly Met Gly Asn Gly Cys Gly Arg 
545                 550                 555                 560 


Ser Asn Glu Arg Ser Ser Cys Glu Leu Glu Val Leu Leu Arg Val Lys 
                565                 570                 575     


Glu Asn Glu Leu Gln Tyr Leu Lys Lys Glu Val Gln Cys Leu Arg Asp 
            580                 585                 590         


Glu Leu Gln Met Met Gln Lys Asp Lys Arg Phe Thr Ser Gly Lys Tyr 
        595                 600                 605             


Gln Asp Val Tyr Val Glu Leu Ser His Ile Lys Thr Arg Ser Glu Arg 
    610                 615                 620                 


Glu Ile Glu Gln Leu Lys Glu His Leu Arg Leu Ala Met Ala Ala Leu 
625                 630                 635                 640 


Gln Glu Lys Glu Ser Met Arg Asn Ser Leu Ala Glu 
                645                 650         

<210>  3649
<211>  4862
<212>  DNA
<213>  Homo sapiens

<400>  3649
aaaaagtttt atgggcggat ggaaggggcc ggggcagcgt cggggaaagg aagggccgga     60

ggcgcggcgg cgggcggccg agaggggcgg cggcggcggc ggcggcgggg ttcccgcgcc    120

gcggagcccg gcccgagagc cgcgtccacg ttcctgcctc ctgctcccgc cgccctgggg    180

cgccgccatg acgcccgatc tgctcaactt caagaaggga tggatgtcga tcttggacga    240

gcctggagag cctccctccc cctcgctcac caccacctct acttcgcagt ggaagaaaca    300

ttggtttgtg ctgacagatt caagtctcaa atattacaga gactccactg ctgaggaggc    360

agatgagctg gatggtgaga tcgacctgcg ttcctgcacg gatgtcactg agtacgcggt    420

gcagcgcaac tatggcttcc agatccacac caaggatgct gtctatacct tgtcggccat    480

gacctcaggc atccggcgga actggatcga ggctctgaga aagaccgtac gtccaacttc    540

agccccagat gtcaccaagc tctcggactc taacaaggag aacgcgctgc acagctacag    600

cacccagaag ggccccctga aggcagggga gcagcgggcg ggctctgagg tcatcagccg    660

gggtggccct cggaaggcgg acgggcagcg tcaggccttg gactacgtgg agctctcgcc    720

gctgacccag gcttccccgc agcgggcccg caccccagcc cgcactcctg accgcctggc    780

caagcaggag gagctggagc gggacctggc ccagcgctcc gaggagcggc gcaagtggtt    840

tgaggccaca gacagcagga ccccagaggt gcctgctggt gaggggccgc gccggggcct    900

gggtgccccc ctgactgagg accagcaaaa ccggcttagt gaggagatcg agaagaagtg    960

gcaggagctg gagaagctgc ccctgcggga gaataagcgg gtgcccctca ctgccctgct   1020

caaccaaagc cgcggagagc gccgagggcc cccaagtgac ggccacgagg cactggagaa   1080

ggaggttcag gctcttcggg cccagctgga ggcgtggcgt ctccaagggg aggctcctca   1140

gagtgcactg agatcccagg aggatggcca catccccccg ggctacatct cacaggaggc   1200

atgtgagcgc agcctggcag agatggagtc ctcgcaccag caggtgatgg aggagctgca   1260

gcggcaccac gagcgggagc tgcagcgcct gcagcaggag aaggagtggc tcctggctga   1320

ggagacggca gccacggcct cagccattga agccatgaag aaggcctacc aggaagagct   1380

gagccgagag ctgagcaaaa cacggagtct ccagcagggc ccggatggcc tccggaagca   1440

gcaccagtca gatgtggagg cactgaagcg agagctgcag gtgctatcgg agcagtactc   1500

gcagaagtgc ctggagattg gggcactcat gcggcaggct gaggagcgcg agcacacgct   1560

gcgccgctgc cagcaggagg gccaggagct gctgcgccac aaccaggagc tgcatggccg   1620

cctgtcagag gagatagacc agctgcgcgg cttcattgcc tcgcagggca tgggcaatgg   1680

ctgcgggcgc agcaacgagc ggagttcctg cgagctagag gtgctgcttc gcgtaaaaga   1740

aaacgaactc cagtacctaa agaaggaggt gcagtgcctc cgggacgagc tccagatgat   1800

gcagaaggac aagcgcttca cctcgggaaa gtaccaggac gtctatgtgg agctgagcca   1860

catcaagaca cggtctgagc gggagatcga gcagctgaag gagcacctgc gtcttgccat   1920

ggccgccctc caggagaagg agtcgatgcg caacagcctg gctgagtaga ggtcccgccc   1980

agctgcagac cctccaggct ggaggaccag ccgccctcct tccctcctgg atggaagtaa   2040

aaagccaagc tttctcccca ccctctgtgg gccacacgtg cacttgcacc caccacacac   2100

acacacacac acacacacac acacacagac acacagacac atacgcacac acgtgcacac   2160

atgtacacac ggatacacac acacacacac acactgcata tctgagcgcg cccctcgcac   2220

tgggtctcac cttgcacctt cttcaggatt ttatatgtga agagattttt atatagattt   2280

ttttcctttt tttccaaaac actttatact ttaaaaaaaa aaaaaaaaag caattcctgg   2340

tggctgtgtg cctccaaccc tggtccccct ctgtctccag ccaccctctg cttgggcttc   2400

tgagctggtg gccctggccc agaggtctgg cggaggccca ggcagcagcc atggcggggt   2460

gtctctacag gggagaggcg ggagcctgcc accctcttcc tgccctacct cctactaaca   2520

cttcctgccc catttggacc cgtaccatgg ggctcaggac agagggagct agcagctggc   2580

ctccatggcc ccacagcctc cttcgaggct gtgctgggtg cagaaccgcc agagccaccc   2640

aaaaggtgtt tctcttctgc tccctgaacc tcttaactta ataaaacgtt ccagcagctc   2700

tggtgtccta gatggctggc agaacaggaa tggagattgg ggtttcttga agtggcttcc   2760

ccactcacac cctacccaca ccccaccctt cctaaagcag cggcctctag gcttctgagg   2820

gtggggctga aaatccaagg tctcccttag tacagactgt gacgccccca gtgtggcttg   2880

caggctagtg gcagcggaag catgtgggaa atagcaagtc cagtcccacc ccaacctact   2940

gaaccagcgt ctgcatttta acagggtgcc ccagtgattc acgtgacctt caaagtctga   3000

ggagccctgg agtagggccc agggcccagg cctgagagag aggcctgggg ctaagactag   3060

ccctgaccat gaccttgggc aagtcacacc cctcactgag cctcagtttg cttctccatc   3120

aaatgggtgt ttttctttca gtcccagtcc tctcctgagg cttttcccag aggtcatgcc   3180

cagccctggg caggggtgag ggcagggttg tggctgccag gcacaggtcc agcgggctgg   3240

gagtcctcac catggctggc tgtgctgatt atggttgcat ggggctggga agaggtccca   3300

tttctgagcc acagaaacag gccacatcca gtaggggtcc tggaaggctg tgagaaccca   3360

gaggagaccc tgacccagcc tgcaggtaga agactgcctt tggaggcagc tttgaaagat   3420

gactcttcca gatggaagaa tcaggaaggg ccttcccacg tggaggcacc agcaggagca   3480

aacgtccctg gtgtgttcag gcaaagagcc acaggagagt gacctcgtgg agtgggaaga   3540

gattgtttcc cattcccttg ccagggattg gttgaggaat ggacaaggct tgcagttcac   3600

gcaagccagt gaaatgcgag gggaagtctt gggagtgggg tggaggaggt catctgggaa   3660

gggtgtcctt ggtcttaaaa agaggcacaa gaggccgggc gcggtggctc ttgcctatta   3720

tcctagcact ttgggaggcc aaggcagggg gatcacttga ggtcaggagt tcgagaccag   3780

cctggccaac atggtgaaac cccgtctcta ctaaaaatac aaaaaattag ccagacgtgg   3840

tgccaagcac ctgtaatccc agctactcag gaggctgagg caggagaatc acttgaaccc   3900

aggaggcaga agttgcagtg agccaagatc gcgccactgc actccagcct gtgtgacaag   3960

ggcgaaactc catctcaaaa aaaaaggggg agggtggcgc aaggagagga cacctctctc   4020

ctggccctgt cgccatcttc cctcatcaat agctaaaaat ggcaaagaag aaagagccag   4080

gaccccgtgc catcaaatcc tccggccttg tgctgccctg tctcggcact gcttgcctta   4140

ggagatcagg agtgttccta gccactggga gatgggatgc ctgccactgg cagctctgcc   4200

gtccatcctc accatcccac cgtcccccca agacagctct ccatcccatc ctctgcctcc   4260

cttctagcct caacctaact cagggctccc ccgtctcaca cctgggttgc aggaacatcc   4320

tcttcaccaa cccccctccc atccctcctc agggctgcct agggcagcta caaaaaccag   4380

gccagcctct gaaaggtgct ccacatctca ttaaaaaccg tgaaatcgca ctgccccact   4440

atcagaatag ctcagaggag aaggtctgcc agtaccaagt gctggtgggg atacggagaa   4500

gagcagctcc caggcgctgc tggtgcaaat gtgctttgtt gcacccacgg caggaaactg   4560

accagcttct catcaagtta aatacgcatc taccctatgg cctagcattt ccactcttgc   4620

ttacacatcc aggagaaatg agtccttaca tgcacaaaag gatgagtacc gtaatactca   4680

catcagcaaa taaacaatac agctgtgtgt cagtagtaga atgaataaat tgtggtcgat   4740

tcatacgtta gaatacagca atttaaaaac aactgctaca cacaaaaatg ttggtgaatc   4800

tttcagacac aatgttgagc aaaaatagcc acagaagagt gtaaggctgt acgattttat   4860

tt                                                                  4862


<210>  3650
<211>  652
<212>  PRT
<213>  Homo sapiens

<400>  3650


Met Gly Gly Trp Lys Gly Pro Gly Gln Arg Arg Gly Lys Glu Gly Pro 
1               5                   10                  15      


Glu Ala Arg Arg Arg Ala Ala Glu Arg Gly Gly Gly Gly Gly Gly Gly 
            20                  25                  30          


Gly Val Pro Ala Pro Arg Ser Pro Ala Arg Glu Pro Arg Pro Arg Ser 
        35                  40                  45              


Cys Leu Leu Leu Pro Pro Pro Trp Gly Ala Ala Met Thr Pro Asp Leu 
    50                  55                  60                  


Leu Asn Phe Lys Lys Gly Trp Met Ser Ile Leu Asp Glu Pro Gly Glu 
65                  70                  75                  80  


Pro Pro Ser Pro Ser Leu Thr Thr Thr Ser Thr Ser Gln Trp Lys Lys 
                85                  90                  95      


His Trp Phe Val Leu Thr Asp Ser Ser Leu Lys Tyr Tyr Arg Asp Ser 
            100                 105                 110         


Thr Ala Glu Glu Ala Asp Glu Leu Asp Gly Glu Ile Asp Leu Arg Ser 
        115                 120                 125             


Cys Thr Asp Val Thr Glu Tyr Ala Val Gln Arg Asn Tyr Gly Phe Gln 
    130                 135                 140                 


Ile His Thr Lys Asp Ala Val Tyr Thr Leu Ser Ala Met Thr Ser Gly 
145                 150                 155                 160 


Ile Arg Arg Asn Trp Ile Glu Ala Leu Arg Lys Thr Val Arg Pro Thr 
                165                 170                 175     


Ser Ala Pro Asp Val Thr Lys Leu Ser Asp Ser Asn Lys Glu Asn Ala 
            180                 185                 190         


Leu His Ser Tyr Ser Thr Gln Lys Gly Pro Leu Lys Ala Gly Glu Gln 
        195                 200                 205             


Arg Ala Gly Ser Glu Val Ile Ser Arg Gly Gly Pro Arg Lys Ala Asp 
    210                 215                 220                 


Gly Gln Arg Gln Ala Leu Asp Tyr Val Glu Leu Ser Pro Leu Thr Gln 
225                 230                 235                 240 


Ala Ser Pro Gln Arg Ala Arg Thr Pro Ala Arg Thr Pro Asp Arg Leu 
                245                 250                 255     


Ala Lys Gln Glu Glu Leu Glu Arg Asp Leu Ala Gln Arg Ser Glu Glu 
            260                 265                 270         


Arg Arg Lys Trp Phe Glu Ala Thr Asp Ser Arg Thr Pro Glu Val Pro 
        275                 280                 285             


Ala Gly Glu Gly Pro Arg Arg Gly Leu Gly Ala Pro Leu Thr Glu Asp 
    290                 295                 300                 


Gln Gln Asn Arg Leu Ser Glu Glu Ile Glu Lys Lys Trp Gln Glu Leu 
305                 310                 315                 320 


Glu Lys Leu Pro Leu Arg Glu Asn Lys Arg Val Pro Leu Thr Ala Leu 
                325                 330                 335     


Leu Asn Gln Ser Arg Gly Glu Arg Arg Gly Pro Pro Ser Asp Gly His 
            340                 345                 350         


Glu Ala Leu Glu Lys Glu Val Gln Ala Leu Arg Ala Gln Leu Glu Ala 
        355                 360                 365             


Trp Arg Leu Gln Gly Glu Ala Pro Gln Ser Ala Leu Arg Ser Gln Glu 
    370                 375                 380                 


Asp Gly His Ile Pro Pro Gly Tyr Ile Ser Gln Glu Ala Cys Glu Arg 
385                 390                 395                 400 


Ser Leu Ala Glu Met Glu Ser Ser His Gln Gln Val Met Glu Glu Leu 
                405                 410                 415     


Gln Arg His His Glu Arg Glu Leu Gln Arg Leu Gln Gln Glu Lys Glu 
            420                 425                 430         


Trp Leu Leu Ala Glu Glu Thr Ala Ala Thr Ala Ser Ala Ile Glu Ala 
        435                 440                 445             


Met Lys Lys Ala Tyr Gln Glu Glu Leu Ser Arg Glu Leu Ser Lys Thr 
    450                 455                 460                 


Arg Ser Leu Gln Gln Gly Pro Asp Gly Leu Arg Lys Gln His Gln Ser 
465                 470                 475                 480 


Asp Val Glu Ala Leu Lys Arg Glu Leu Gln Val Leu Ser Glu Gln Tyr 
                485                 490                 495     


Ser Gln Lys Cys Leu Glu Ile Gly Ala Leu Met Arg Gln Ala Glu Glu 
            500                 505                 510         


Arg Glu His Thr Leu Arg Arg Cys Gln Gln Glu Gly Gln Glu Leu Leu 
        515                 520                 525             


Arg His Asn Gln Glu Leu His Gly Arg Leu Ser Glu Glu Ile Asp Gln 
    530                 535                 540                 


Leu Arg Gly Phe Ile Ala Ser Gln Gly Met Gly Asn Gly Cys Gly Arg 
545                 550                 555                 560 


Ser Asn Glu Arg Ser Ser Cys Glu Leu Glu Val Leu Leu Arg Val Lys 
                565                 570                 575     


Glu Asn Glu Leu Gln Tyr Leu Lys Lys Glu Val Gln Cys Leu Arg Asp 
            580                 585                 590         


Glu Leu Gln Met Met Gln Lys Asp Lys Arg Phe Thr Ser Gly Lys Tyr 
        595                 600                 605             


Gln Asp Val Tyr Val Glu Leu Ser His Ile Lys Thr Arg Ser Glu Arg 
    610                 615                 620                 


Glu Ile Glu Gln Leu Lys Glu His Leu Arg Leu Ala Met Ala Ala Leu 
625                 630                 635                 640 


Gln Glu Lys Glu Ser Met Arg Asn Ser Leu Ala Glu 
                645                 650         

<210>  3651
<211>  510
<212>  DNA
<213>  Homo sapiens

<400>  3651
cttacctctc caggctcgtc caagatcgac atccatccct tcttgaagtt gagcagatcg     60

ggctgtgggg agatgaggag ggagagatgg ggtctcccta tgtttcccag gttggtttca    120

aactcctgag ctcaagtgat ccgctcacct cggcctccaa aaatgctggg attataggtg    180

tgagccaatg tgcccggcca accaattcca tctccacctg acaaggccct ataatcacag    240

gaggacacct ccctcaggaa ggctgctgcc accagcaggg atgtgctgtc catcttccaa    300

gcaccccaca cgctgcttcc ggcagcctta cccttgctca gcacgtgctg cccccaggac    360

aggcaactgt gaaagaaagc tggaacggac ctggatacaa attctggctt agcctgggac    420

tcactgagtt acctggggca tgacacttca cctcgccaca ccttggtttc ctcatctgtt    480

tgattaagat gttactacca accttcaagg                                     510


<210>  3652
<211>  74
<212>  PRT
<213>  Homo sapiens

<400>  3652


Met Cys Pro Ala Asn Gln Phe His Leu His Leu Thr Arg Pro Tyr Asn 
1               5                   10                  15      


His Arg Arg Thr Pro Pro Ser Gly Arg Leu Leu Pro Pro Ala Gly Met 
            20                  25                  30          


Cys Cys Pro Ser Ser Lys His Pro Thr Arg Cys Phe Arg Gln Pro Tyr 
        35                  40                  45              


Pro Cys Ser Ala Arg Ala Ala Pro Arg Thr Gly Asn Cys Glu Arg Lys 
    50                  55                  60                  


Leu Glu Arg Thr Trp Ile Gln Ile Leu Ala 
65                  70                  

<210>  3653
<211>  513
<212>  DNA
<213>  Homo sapiens

<400>  3653
ctccccctcg ctcaccacca cctctacttc gcagtggaag aaacattggt ttgtgctgac     60

agattcaagt ctcaaatatt acagagactc cactgctgag gaggcagatg agctggatgg    120

tgagatcgac ctgcgttcct gcacggatgt cactgagtac gcggtgcagc gcaactatgg    180

cttccagatc cacgtgaggc tgtgtgcagc ttgggggctg gtggtgggca gcatggctgg    240

aggtccctgg gggaggtttt ggtgttgaac atggctcacc atggagactg gatcccttca    300

ctcatttacc cagaggccct atcttcagag ccagagctgt gatgccaaca cttagcatat    360

ctgggggaga cgctggagcc agcagggctc ttcccaggcc aatggaaggg aggttttgta    420

ccccctgccc accccagact caagacctta gatgcatcct gggaaggaag ggccaccctc    480

cctggggtcc atagtgggga gggagtcatg cgg                                 513


<210>  3654
<211>  50
<212>  PRT
<213>  Homo sapiens

<400>  3654


Met Pro Thr Leu Ser Ile Ser Gly Gly Asp Ala Gly Ala Ser Arg Ala 
1               5                   10                  15      


Leu Pro Arg Pro Met Glu Gly Arg Phe Cys Thr Pro Cys Pro Pro Gln 
            20                  25                  30          


Thr Gln Asp Leu Arg Cys Ile Leu Gly Arg Lys Gly His Pro Pro Trp 
        35                  40                  45              


Gly Pro 
    50  

<210>  3655
<211>  986
<212>  DNA
<213>  Homo sapiens

<400>  3655
gagccacatc aagacacggt ctgagcggga gatcgagcag ctgaaggagc acctgcgtct     60

tgccatggcc gccctccagg agaaggagtc gatgcgcaac agcctggctg agtagaggtg    120

gatgccgagg cgtgtgccct gcagggtggg caggggctga ggctctccca cacccgggac    180

tccctggacc accccagcca ggccacttcc ttcttctggc ctccaattcc cgttctgtaa    240

aaaggacaat gaaaccagca acacggggtt gttgcagaga tcccatcaga cccgggccac    300

aggctgcttc atcagcttaa gcctgttcct ccagagctgg gcggcacagt gcagagccac    360

agcctactca gtgcaccccc cttcttgggg ctggaggcaa atgcagcgtg cacatccctg    420

acccccacag tgaatctcca ctgagcttca cacacacaca cacacgtgca cttgcaccca    480

ctgcatatct gagcgcgccc ctcgcactgg gtctcacctt gcaccttctt caggatttta    540

tatgtgaaga gatttttata tagatttttt tccttttttt ccaaaacact ttatacttta    600

aaaaaaaaaa aaaaaagcaa ttcctggtgg ctgtgtgcct ccaaccctgg tccccctctg    660

tctccagcca ccctctgctt gggcttctga gctggtggcc ctggcccaga ggtctggcgg    720

aggcccaggc agcagccatg gcggggtgtc tctacagggg agaggcggga gcctgccacc    780

ctcttcctgc cctacctcct actaacactt cctgccccat ttggacccgt accatggggc    840

tcaggacaga gggagctagc agctggcctc catggcccca cagcctcctt cgaggctgtg    900

ctgggtgcag aaccgccaga gccacccaaa aggtgtttct cttctgctcc ctgaacctct    960

taacttaata aaacgttcca gcagct                                         986


<210>  3656
<211>  76
<212>  PRT
<213>  Homo sapiens

<400>  3656


Met Ala Gly Cys Leu Tyr Arg Gly Glu Ala Gly Ala Cys His Pro Leu 
1               5                   10                  15      


Pro Ala Leu Pro Pro Thr Asn Thr Ser Cys Pro Ile Trp Thr Arg Thr 
            20                  25                  30          


Met Gly Leu Arg Thr Glu Gly Ala Ser Ser Trp Pro Pro Trp Pro His 
        35                  40                  45              


Ser Leu Leu Arg Gly Cys Ala Gly Cys Arg Thr Ala Arg Ala Thr Gln 
    50                  55                  60                  


Lys Val Phe Leu Phe Cys Ser Leu Asn Leu Leu Thr 
65                  70                  75      

<210>  3657
<211>  3149
<212>  DNA
<213>  Homo sapiens

<400>  3657
gagccacatc aagacacggt ctgagcggga gatcgagcag ctgaaggagc acctgcgtct     60

tgccatggcc gccctccagg agaaggagtc gatgcgcaac agcctggctg agtagaggtg    120

gatgccgagg cgtgtgccct gcagggtggg caggggctga ggctctccca cacccgggac    180

tccctggacc accccagcca ggccacttcc ttcttctggc ctccaattcc cgttctgtaa    240

aaaggacaat gaaaccagca acacggggtt gttgcagaga tcccatcaga cccgggccac    300

aggctgcttc atcagcttaa gcctgttcct ccagagctgg gcggcacagt gcagagccac    360

agcctactca gtgcaccccc cttcttgggg ctggaggcaa atgcagcgtg cacatccctg    420

acccccacag tgaatctcca ctgagcttca cacacacaca cacacgtgca cttgcaccca    480

ctgcatatct gagcgcgccc ctcgcactgg gtctcacctt gcaccttctt caggatttta    540

tatgtgaaga gatttttata tagatttttt tccttttttt ccaaaacact ttatacttta    600

aaaaaaaaaa aaaaaagcaa ttcctggtgg ctgtgtgcct ccaaccctgg tccccctctg    660

tctccagcca ccctctgctt gggcttctga gctggtggcc ctggcccaga ggtctggcgg    720

aggcccaggc agcagccatg gcggggtgtc tctacagggg agaggcggga gcctgccacc    780

ctcttcctgc cctacctcct actaacactt cctgccccat ttggacccgt accatggggc    840

tcaggacaga gggagctagc agctggcctc catggcccca cagcctcctt cgaggctgtg    900

ctgggtgcag aaccgccaga gccacccaaa aggtgtttct cttctgctcc ctgaacctct    960

taacttaata aaacgttcca gcagctctgg tgtcctagat ggctggcaga acaggaatgg   1020

agattggggt ttcttgaagt ggcttcccca ctcacaccct acccacaccc cacccttcct   1080

aaagcagcgg cctctaggct tctgagggtg gggctgaaaa tccaaggtct cccttagtac   1140

agactgtgac gcccccagtg tggcttgcag gctagtggca gcggaagcat gtgggaaata   1200

gcaagtccag tcccacccca acctactgaa ccagcgtctg cattttaaca gggtgcccca   1260

gtgattcacg tgaccttcaa agtctgagga gccctggagt agggcccagg gcccaggcct   1320

gagagagagg cctggggcta agactagccc tgaccatgac cttgggcaag tcacacccct   1380

cactgagcct cagtttgctt ctccatcaaa tgggtgtttt tctttcagtc ccagtcctct   1440

cctgaggctt ttcccagagg tcatgcccag ccctgggcag gggtgagggc agggttgtgg   1500

ctgccaggca caggtccagc gggctgggag tcctcaccat ggctggctgt gctgattatg   1560

gttgcatggg gctgggaaga ggtcccattt ctgagccaca gaaacaggcc acatccagta   1620

ggggtcctgg aaggctgtga gaacccagag gagaccctga cccagcctgc aggtagaaga   1680

ctgcctttgg aggcagcttt gaaagatgac tcttccagat ggaagaatca ggaagggcct   1740

tcccacgtgg aggcaccagc aggagcaaac gtccctggtg tgttcaggca aagagccaca   1800

ggagagtgac ctcgtggagt gggaagagat tgtttcccat tcccttgcca gggattggtt   1860

gaggaatgga caaggcttgc agttcacgca agccagtgaa atgcgagggg aagtcttggg   1920

agtggggtgg aggaggtcat ctgggaaggg tgtccttggt cttaaaaaga ggcacaagag   1980

gccgggcgcg gtggctcttg cctattatcc tagcactttg ggaggccaag gcagggggat   2040

cacttgaggt caggagttcg agaccagcct ggccaacatg gtgaaacccc gtctctacta   2100

aaaatacaaa aaattagcca gacgtggtgc caagcacctg taatcccagc tactcaggag   2160

gctgaggcag gagaatcact tgaacccagg aggcagaagt tgcagtgagc caagatcgcg   2220

ccactgcact ccagcctgtg tgacaagggc gaaactccat ctcaaaaaaa aagggggagg   2280

gtggcgcaag gagaggacac ctctctcctg gccctgtcgc catcttccct catcaatagc   2340

taaaaatggc aaagaagaaa gagccaggac cccgtgccat caaatcctcc ggccttgtgc   2400

tgccctgtct cggcactgct tgccttagga gatcaggagt gttcctagcc actgggagat   2460

gggatgcctg ccactggcag ctctgccgtc catcctcacc atcccaccgt ccccccaaga   2520

cagctctcca tcccatcctc tgcctccctt ctagcctcaa cctaactcag ggctcccccg   2580

tctcacacct gggttgcagg aacatcctct tcaccaaccc ccctcccatc cctcctcagg   2640

gctgcctagg gcagctacaa aaaccaggcc agcctctgaa aggtgctcca catctcatta   2700

aaaaccgtga aatcgcactg ccccactatc agaatagctc agaggagaag gtctgccagt   2760

accaagtgct ggtggggata cggagaagag cagctcccag gcgctgctgg tgcaaatgtg   2820

ctttgttgca cccacggcag gaaactgacc agcttctcat caagttaaat acgcatctac   2880

cctatggcct agcatttcca ctcttgctta cacatccagg agaaatgagt ccttacatgc   2940

acaaaaggat gagtaccgta atactcacat cagcaaataa acaatacagc tgtgtgtcag   3000

tagtagaatg aataaattgt ggtcgattca tacgttagaa tacagcaatt taaaaacaac   3060

tgctacacac aaaaatgttg gtgaatcttt cagacacaat gttgagcaaa aatagccaca   3120

gaagagtgta aggctgtacg attttattt                                     3149


<210>  3658
<211>  221
<212>  PRT
<213>  Homo sapiens

<400>  3658


Met Ala Lys Lys Lys Glu Pro Gly Pro Arg Ala Ile Lys Ser Ser Gly 
1               5                   10                  15      


Leu Val Leu Pro Cys Leu Gly Thr Ala Cys Leu Arg Arg Ser Gly Val 
            20                  25                  30          


Phe Leu Ala Thr Gly Arg Trp Asp Ala Cys His Trp Gln Leu Cys Arg 
        35                  40                  45              


Pro Ser Ser Pro Ser His Arg Pro Pro Lys Thr Ala Leu His Pro Ile 
    50                  55                  60                  


Leu Cys Leu Pro Ser Ser Leu Asn Leu Thr Gln Gly Ser Pro Val Ser 
65                  70                  75                  80  


His Leu Gly Cys Arg Asn Ile Leu Phe Thr Asn Pro Pro Pro Ile Pro 
                85                  90                  95      


Pro Gln Gly Cys Leu Gly Gln Leu Gln Lys Pro Gly Gln Pro Leu Lys 
            100                 105                 110         


Gly Ala Pro His Leu Ile Lys Asn Arg Glu Ile Ala Leu Pro His Tyr 
        115                 120                 125             


Gln Asn Ser Ser Glu Glu Lys Val Cys Gln Tyr Gln Val Leu Val Gly 
    130                 135                 140                 


Ile Arg Arg Arg Ala Ala Pro Arg Arg Cys Trp Cys Lys Cys Ala Leu 
145                 150                 155                 160 


Leu His Pro Arg Gln Glu Thr Asp Gln Leu Leu Ile Lys Leu Asn Thr 
                165                 170                 175     


His Leu Pro Tyr Gly Leu Ala Phe Pro Leu Leu Leu Thr His Pro Gly 
            180                 185                 190         


Glu Met Ser Pro Tyr Met His Lys Arg Met Ser Thr Val Ile Leu Thr 
        195                 200                 205             


Ser Ala Asn Lys Gln Tyr Ser Cys Val Ser Val Val Glu 
    210                 215                 220     

<210>  3659
<211>  1215
<212>  DNA
<213>  Homo sapiens

<400>  3659
gttgctttga gaaaggtctt actctgacac ccaggctgga gtgcagtggt gcaatcacgg     60

ctcactgcag cctcaacctc ctaggctcaa gggatcctcc cacctcagcc ttctgagtag    120

ctgggaccac aggccctcac caccatgccc agataatttt tgcacttttt gtataggtgg    180

ggtttcgccg tgatttccca ggctggtctc gaactcctgg gctcaagcaa tacacctgcc    240

tcagcctccc aaaattctga gattacaggt gtgagccgct gcacctggcc aaagtgttct    300

tatttttgct ttttcaacgc cacatctacc tggagcatcc tctttctgat aagtcctcat    360

ggacttccta tggcatgcag gagaggccac cctatggctg agctgcttgg gaaggagcca    420

ggaagagcgg atctggctgt accttagggg ctgagaggtg gtggaaggac ccactcagca    480

cccttgcttg gccttggggt ggcctcgcag cccctcagcc caggcctcag ccctgccgca    540

ccttgtcttt caggtcccgc ccagctgcag accctccagg ctggaggacc agccgccctc    600

cttccctcct ggatggaagt aaaaagccaa gctttctccc caccctctgt gggccacacg    660

tgcacttgca cccaccacac acacacacac acacacacac acacacacag acacacagac    720

acatacgcac acacgtgcac acatgtacac acggatacac acacacacac acacactgca    780

tatctgagcg cgcccctcgc actgggtctc accttgcacc ttcttcagga ttttatatgt    840

gaagagattt ttatatagat ttttttcctt tttttccaaa acactttata ctttaaaaaa    900

aaaaaaaaaa agcaattcct gctggtggcc ctggcccaga ggtctggcgg aggcccaggc    960

agcagccatg gcggggtgtc tctacagggg agaggcggga gcctgccacc ctcttcctgc   1020

cctacctcct actaacactt cctgccccat ttggacccgt accatggggc tcaggacaga   1080

gggagctagc agctggcctc catggcccca cagcctcctt cgaggctgtg ctgggtgcag   1140

aaccgccaga gccacccaaa aggtgtttct cttctgctcc ctgaacctct taacttaata   1200

aaacgttcca gcagc                                                    1215


<210>  3660
<211>  81
<212>  PRT
<213>  Homo sapiens

<400>  3660


Met Glu Val Lys Ser Gln Ala Phe Ser Pro Pro Ser Val Gly His Thr 
1               5                   10                  15      


Cys Thr Cys Thr His His Thr His Thr His Thr His Thr His Thr His 
            20                  25                  30          


Arg His Thr Asp Thr Tyr Ala His Thr Cys Thr His Val His Thr Asp 
        35                  40                  45              


Thr His Thr His Thr His Thr Ala Tyr Leu Ser Ala Pro Leu Ala Leu 
    50                  55                  60                  


Gly Leu Thr Leu His Leu Leu Gln Asp Phe Ile Cys Glu Glu Ile Phe 
65                  70                  75                  80  


Ile 
    

<210>  3661
<211>  809
<212>  DNA
<213>  Homo sapiens

<400>  3661
tcccgcctct cccctgtaga gacaccccgc catggctgct gcagaggggg accagggttg     60

gaggcacaca gccaccagga attgcttttt tttttttttt ttaaagtata aagtgttttg    120

gaaaaaaagg aaaaaaatct atataaaaat ctcttcacat ataaaatcct gaagaaggtg    180

caaggtgaga cccagtgcga ggggcgcgct cagatatgca gtgtgtgtgt gtgtgtgtgt    240

atccgtgtgt acatgtgtgc acgtgtgtgc gtatgtgtct gtgtgtctgt gtgtgtgtgt    300

gtgtgtgtgt gtgtgtgtgt ggtgggtgca agtgcacgtg tggcccacag agggtgggga    360

gaaagcttgg ctttttactt ccatccagga gggaaggagg gcggctggtc ctccagcctg    420

gagggtctgc agctgggcgg gacctgaaag acaaggtgcg gcagggctga ggcctgggct    480

gaggggctgc gaggccaccc caaggccaag caagggtgct gagtgggtcc ttccaccacc    540

tctcagcccc taaggtacag ccagatccgc tcttcctggc tccttcccaa gcagctcagc    600

catagggtgg cctctcctgc atgccatagg aagtccatga ggacttatca gaaagaggat    660

gctccaggta gatgtggcgt tgaaaaagca aaaataagaa cactttggcc aggtgcagcg    720

gctcacacct gtaatctcag aattttggga ggctgaggca ggtgtattgc ttgagcccag    780

gagttcgaga ccagcctggg aaatcacgg                                      809


<210>  3662
<211>  46
<212>  PRT
<213>  Homo sapiens

<400>  3662


Met Ala Ala Ala Glu Gly Asp Gln Gly Trp Arg His Thr Ala Thr Arg 
1               5                   10                  15      


Asn Cys Phe Phe Phe Phe Phe Leu Lys Tyr Lys Val Phe Trp Lys Lys 
            20                  25                  30          


Arg Lys Lys Ile Tyr Ile Lys Ile Ser Ser His Ile Lys Ser 
        35                  40                  45      

<210>  3663
<211>  1356
<212>  DNA
<213>  Homo sapiens

<400>  3663
attgccgtcg gggcgtcgct cctcttcctc aacatcttag cttttgcggc gctgtactac     60

aaaaaggaca agaggcgcca tgagactcac aggcgcccca gtccccagag aaacaccaca    120

aatgatatcg ctcacatcca gaacgaagag atcatgtctc tgcagatgaa gcagctggaa    180

cacgatcacg agtgtgagtc gctgcaggca cacgacacac tgaggctcac ctgcccgcca    240

gactacaccc tcacgctgcg ccggtcgcca gatgacatcc cacttatgac gccaaacacc    300

atcaccatga ttccaaacac actgacgggg atgcagcctt tgcacacttt taacaccttc    360

agtggaggac aaaacagtac aaatttaccc cacggacatt ccaccactag agtatagctt    420

tgccctattt cccttcctat ccctctgccc tacccgctca gcaacataga agagggaagg    480

aaagagagaa ggaaagagag agagaaagaa agtctccaga ccaggaatgt ttttgtccca    540

ctgacttaag acaaaaatgc aaaaaggcag tcatcccatc ccggcagacc cttatcgttg    600

gtgttttcca gtattacaag atcaacttct gaccctgtga aatgtgagaa gtacacattt    660

ctgttaaaat aactgcttta agatctctac cactccaatc gatgtttagt gtgataggac    720

atcaccattt caaggccccg ggtgtttcca acgtcatgga agcagctgac acttctgaaa    780

ctcagccaag gacacttgat attttttaat tacaatggaa ttatgtgtgg catccatgtt    840

ggtttcgtct gtctgtaatg tgaattccag tatttgttta gtatttccag ttgtctcctg    900

ctagcaatat gtacagtaac gcgtcaggct tgtgacattt gaataaggaa aaacagagtt    960

cctgttaagt gaataacttt agcttttaca ggggattatg atcaaaagtg attttagtac   1020

atcttaaatg atatcttatt tctacatgga aagaagttat agaatcttca tagagttcta   1080

tgagaaaaaa tatacttgct atctataaaa aagagaaaaa agaaaaaaaa tgagaaaaaa   1140

gtaagaaaaa aaaaaatcct gtcctaggct tttactcttg atcttcaaag gcacgcaggg   1200

tttaatggtt ccttgggtta ttattttgca gttttgtttt ttattttgcc ttaagtaatg   1260

atagaagata tatatggccg gacacatatg tataaacttt tcagcagcat ttttaataat   1320

aaaatatcac agtattttct aatgctttgt gcaaat                             1356


<210>  3664
<211>  87
<212>  PRT
<213>  Homo sapiens

<400>  3664


Met Ser Leu Gln Met Lys Gln Leu Glu His Asp His Glu Cys Glu Ser 
1               5                   10                  15      


Leu Gln Ala His Asp Thr Leu Arg Leu Thr Cys Pro Pro Asp Tyr Thr 
            20                  25                  30          


Leu Thr Leu Arg Arg Ser Pro Asp Asp Ile Pro Leu Met Thr Pro Asn 
        35                  40                  45              


Thr Ile Thr Met Ile Pro Asn Thr Leu Thr Gly Met Gln Pro Leu His 
    50                  55                  60                  


Thr Phe Asn Thr Phe Ser Gly Gly Gln Asn Ser Thr Asn Leu Pro His 
65                  70                  75                  80  


Gly His Ser Thr Thr Arg Val 
                85          

<210>  3665
<211>  5704
<212>  DNA
<213>  Homo sapiens

<400>  3665
atttaagcga ttttttttcc ctccttcatc tccgggcctc ggataagatg acggcttggg     60

tgatgcacga aataacgcac gtgattgatt agacctggct tggcttggct agggaacgat    120

ccaggcgcgc tggagacccc gcgtgaagat gaaatgacgg ctgccttgga gttttcataa    180

gaaattgtcc ctggaggtgt tggatgatca cagcttcctt ggagcattgc agttgctgga    240

atccagtttc aggattaagg gagggctgcc tccttgcaat gggctgccaa gaaaacggct    300

gtgcttgttc ttaacctcag gctctgtctg tgatcagtct gagagtctct cccaggtcta    360

ctgctccctg gaaagcccta tctctctgca ggctcgcctc tgggctttgt ctccttggag    420

ccacatcact gggacagctg tggatgtgga tgcagatttg aaccatgtca cggccccagg    480

gactgctatg gcttcctttg ttgttcaccc cggtctgcgt catgttaaac tccaatgtcc    540

tcctgtggtt aactgctctt gccatcaagt tcaccctcat tgacagccaa gcacagtatc    600

cagttgtcaa cacaaattat ggcaaaatcc ggggcctaag aacaccgtta cccaatgaga    660

tcttgggtcc agtggagcag tacttagggg tcccctatgc ctcacccccc actggagaga    720

ggcggtttca gcccccagaa cccccgtcct cctggactgg catccgaaat actactcagt    780

ttgctgctgt gtgcccccag cacctggatg agagatcctt actgcatgac atgctgccca    840

tctggtttac cgccaatttg gatactttga tgacctatgt tcaagatcaa aatgaagact    900

gcctttactt aaacatctac gtgcccacgg aagatgatat tcatgatcag aacagtaaga    960

agcccgtcat ggtctatatc catgggggat cttacatgga gggcaccggc aacatgattg   1020

acggcagcat tttggcaagc tacggaaacg tcatcgtgat caccattaac taccgtctgg   1080

gaatactagg gtttttaagt accggtgacc aggcagcaaa aggcaactat gggctcctgg   1140

atcagattca agcactgcgg tggattgagg agaatgtggg agcctttggc ggggacccca   1200

agagagtgac catctttggc tcgggggctg gggcctcctg tgtcagcctg ttgaccctgt   1260

cccactactc agaaggtctc ttccagaagg ccatcattca gagcggcacc gccctgtcca   1320

gctgggcagt gaactaccag ccggccaagt acactcggat attggcagac aaggtcggct   1380

gcaacatgct ggacaccacg gacatggtag aatgcctgcg gaacaagaac tacaaggagc   1440

tcatccagca gaccatcacc ccggccacct accacatagc cttcgggccg gtgatcgacg   1500

gcgacgtcat cccagacgac ccccagatcc tgatggagca aggcgagttc ctcaactacg   1560

acatcatgct gggcgtcaac caaggggaag gcctgaagtt cgtggacggc atcgtggata   1620

acgaggacgg tgtgacgccc aacgactttg acttctccgt gtccaacttc gtggacaacc   1680

tttacggcta ccctgaaggg aaagacactt tgcgggagac tatcaagttc atgtacacag   1740

actgggccga taaggaaaac ccggagacgc ggcggaaaac cctggtggct ctctttactg   1800

accaccagtg ggtggccccc gccgtggcca ccgccgacct gcacgcgcag tacggctccc   1860

ccacctactt ctatgccttc tatcatcact gccaaagcga aatgaagccc agctgggcag   1920

attcggccca tggtgatgag gtcccctatg tcttcggcat ccccatgatc ggtcccaccg   1980

agctcttcag ttgtaacttt tccaagaacg acgtcatgct cagcgccgtg gtcatgacct   2040

actggacgaa cttcgccaaa actggtgatc caaatcaacc agttcctcag gataccaagt   2100

tcattcacac aaaacccaac cgctttgaag aagtggcctg gtccaagtat aatcccaaag   2160

accagctcta tctgcatatt ggcttgaaac ccagagtgag agatcactac cgggcaacga   2220

aagtggcttt ctggttggaa ctcgttcctc atttgcacaa cttgaacgag atattccagt   2280

atgtttcaac aaccacaaag gttcctccac cagacatgac atcatttccc tatggcaccc   2340

ggcgatctcc cgccaagata tggccaacca ccaaacgccc agcaatcact cctgccaaca   2400

atcccaaaca ctctaaggac cctcacaaaa cagggcctga ggacacaact gtcctcattg   2460

aaaccaaacg agattattcc accgaattaa gtgtcaccat tgccgtcggg gcgtcgctcc   2520

tcttcctcaa catcttagct tttgcggcgc tgtactacaa aaaggacaag aggcgccatg   2580

agactcacag gcgccccagt ccccagagaa acaccacaaa tgatatcgct cacatccaga   2640

acgaagagat catgtctctg cagatgaagc agctggaaca cgatcacgag tgtgagtcgc   2700

tgcaggcaca cgacacactg aggctcacct gcccgccaga ctacaccctc acgctgcgcc   2760

ggtcgccaga tgacatccca cttatgacgc caaacaccat caccatgatt ccaaacacac   2820

tgacggggat gcagcctttg cacactttta acaccttcag tggaggacaa aacagtacaa   2880

atttacccca cggacattcc accactagag tatagctttg ccctatttcc cttcctatcc   2940

ctctgcccta cccgctcagc aacatagaag agggaaggaa agagagaagg aaagagagag   3000

agaaagaaag tctccagacc aggaatgttt ttgtcccact gacttaagac aaaaatgcaa   3060

aaaggcagtc atcccatccc ggcagaccct tatcgttggt gttttccagt attacaagat   3120

caacttctga ccctgtgaaa tgtgagaagt acacatttct gttaaaataa ctgctttaag   3180

atctctacca ctccaatcga tgtttagtgt gataggacat caccatttca aggccccggg   3240

tgtttccaac gtcatggaag cagctgacac ttctgaaact cagccaagga cacttgatat   3300

tttttaatta caatggaagt ttaaacattt ctttctgtgc cacacaatgg atggctctcc   3360

ttaagtgaag aaagagtcaa tgagattttg cccagcacat ggagctgtaa tccagagaga   3420

aggaaacgta gaaatttatt attaaaagaa tggactgtgc agcgaaatct gtacggttct   3480

gtgcaaagag gtgttttgcc agcctgaact atatttaaga gactttgtaa aaaagaaaaa   3540

tgtatatagc tgtgagttta aacaaaaacc acaaacagac aaacaagaaa aaaagctttt   3600

attggtgttt tcactttgaa agagctttta gcaaggttgt gcttttcatt gtgctctgta   3660

cgtatataaa tatatatata tatacacaca cacacacaca ttagtcatat cacctctgtt   3720

tcctccccaa caaaagaggc ttttcttctt aattacttgt ggtaaacaaa gacatgggat   3780

tttcttacat gagattctca tttgtaggag gatgtgatgt cccacagaag acccagacgg   3840

tctgtgtggc ctatttcccc cgtcaggttg cacaggtgca tgcaagagca ttcttaggag   3900

accactgttt tgaaaaactt ttgacttgta cgtgttagcc ttcatgaaat tgcagtacag   3960

agatgggtcc ccaaagtgga gtgtatttac agcttgttaa attagagaca tgcacacaca   4020

aagaatcagt agggagaaac aaaaatacaa gtcccgttct gtagctctgg ccctttgaat   4080

atgtttagga agagttgctt cccatttcag ggccctgcca aaaaaagaag aaagcttgcc   4140

tttggtgggg ctatgcccct tggagtaaat acggctctgt gttccctagc agctgcggga   4200

gggtttggcc gatgaagtac ctgctcagct tagctaatca gattgaagga agacatgtgt   4260

ctttcctttt tgtttaagca ctcggtccct tatttatcag taagcaggtt tttaaaaatc   4320

ttttatatca tttatgggat caaacatatg attgtctgaa aacatcactt tttgtggatt   4380

tgtgtatccg gtcaccaaac ggtgaatatt atagaagaat gggggaagaa aggatagaat   4440

attaaaactg ctttgcatgg gttttctggg aaattaggat aacttcactg agaagacatt   4500

gaatggaaat tattcaccca ttttaaattg gtgacctagg gatcagagat ttgtctttcc   4560

aacagcttgt cattttttca tttctcttct catttttcag gaaagttttg agtgttataa   4620

ggtggaagga aacatagtag caatggatac ttttttgaaa aattattgca ttaccaagaa   4680

acagtagcca aagatatttg aagatcatgt tcctcggctc cattgtgggt tattctagaa   4740

atccagtctt aaatctctcc gctaaagtgg acattcccca taaaaattgt ccagctgcct   4800

ggctcttttg caataacaac ctttgattac tgaatcccta cactcaaact atagtgatat   4860

atcagtgttt gagagtgacc tctagaaaaa agaaaagtgt ttttagaaat gcgtacaagt   4920

cacccccaaa tcctattgct tatcttgggt taaatttgag agtgattctc tgtatataaa   4980

tatgtgaaat attattatct caacttagca cacgtgaagc aacatttctt tcctacagag   5040

aggtgtcatg gtaagatttc attccgaatt cattgtttca tagagctatg atcaggccat   5100

ttctgcaagc aatgtatgac cccacctgag caaccacaaa taggctctct gtgaaactac   5160

aaaggaagtt atgtgtggca tccatgttgg tttcgtctgt ctgtaatgtg aattccagta   5220

tttgtttagt atttccagtt gtctcctgct agcaatatgt acagtaacgc gtcaggcttg   5280

tgacatttga ataaggaaaa acagagttcc tgttaagtga ataactttag cttttacagg   5340

ggattatgat caaaagtgat tttagtacat cttaaatgat atcttatttc tacatggaaa   5400

gaagttatag aatcttcata gagttctatg agaaaaaata tacttgctat ctataaaaaa   5460

gagaaaaaag aaaaaaaatg agaaaaaagt aagaaaaaaa aaaatcctgt cctaggcttt   5520

tactcttgat cttcaaaggc acgcagggtt taatggttcc ttgggttatt attttgcagt   5580

tttgtttttt attttgcctt aagtaatgat agaagatata tatggccgga cacatatgta   5640

taaacttttc agcagcattt ttaataataa aatatcacag tattttctaa tgctttgtgc   5700

aaat                                                                5704


<210>  3666
<211>  816
<212>  PRT
<213>  Homo sapiens

<400>  3666


Met Ser Arg Pro Gln Gly Leu Leu Trp Leu Pro Leu Leu Phe Thr Pro 
1               5                   10                  15      


Val Cys Val Met Leu Asn Ser Asn Val Leu Leu Trp Leu Thr Ala Leu 
            20                  25                  30          


Ala Ile Lys Phe Thr Leu Ile Asp Ser Gln Ala Gln Tyr Pro Val Val 
        35                  40                  45              


Asn Thr Asn Tyr Gly Lys Ile Arg Gly Leu Arg Thr Pro Leu Pro Asn 
    50                  55                  60                  


Glu Ile Leu Gly Pro Val Glu Gln Tyr Leu Gly Val Pro Tyr Ala Ser 
65                  70                  75                  80  


Pro Pro Thr Gly Glu Arg Arg Phe Gln Pro Pro Glu Pro Pro Ser Ser 
                85                  90                  95      


Trp Thr Gly Ile Arg Asn Thr Thr Gln Phe Ala Ala Val Cys Pro Gln 
            100                 105                 110         


His Leu Asp Glu Arg Ser Leu Leu His Asp Met Leu Pro Ile Trp Phe 
        115                 120                 125             


Thr Ala Asn Leu Asp Thr Leu Met Thr Tyr Val Gln Asp Gln Asn Glu 
    130                 135                 140                 


Asp Cys Leu Tyr Leu Asn Ile Tyr Val Pro Thr Glu Asp Asp Ile His 
145                 150                 155                 160 


Asp Gln Asn Ser Lys Lys Pro Val Met Val Tyr Ile His Gly Gly Ser 
                165                 170                 175     


Tyr Met Glu Gly Thr Gly Asn Met Ile Asp Gly Ser Ile Leu Ala Ser 
            180                 185                 190         


Tyr Gly Asn Val Ile Val Ile Thr Ile Asn Tyr Arg Leu Gly Ile Leu 
        195                 200                 205             


Gly Phe Leu Ser Thr Gly Asp Gln Ala Ala Lys Gly Asn Tyr Gly Leu 
    210                 215                 220                 


Leu Asp Gln Ile Gln Ala Leu Arg Trp Ile Glu Glu Asn Val Gly Ala 
225                 230                 235                 240 


Phe Gly Gly Asp Pro Lys Arg Val Thr Ile Phe Gly Ser Gly Ala Gly 
                245                 250                 255     


Ala Ser Cys Val Ser Leu Leu Thr Leu Ser His Tyr Ser Glu Gly Leu 
            260                 265                 270         


Phe Gln Lys Ala Ile Ile Gln Ser Gly Thr Ala Leu Ser Ser Trp Ala 
        275                 280                 285             


Val Asn Tyr Gln Pro Ala Lys Tyr Thr Arg Ile Leu Ala Asp Lys Val 
    290                 295                 300                 


Gly Cys Asn Met Leu Asp Thr Thr Asp Met Val Glu Cys Leu Arg Asn 
305                 310                 315                 320 


Lys Asn Tyr Lys Glu Leu Ile Gln Gln Thr Ile Thr Pro Ala Thr Tyr 
                325                 330                 335     


His Ile Ala Phe Gly Pro Val Ile Asp Gly Asp Val Ile Pro Asp Asp 
            340                 345                 350         


Pro Gln Ile Leu Met Glu Gln Gly Glu Phe Leu Asn Tyr Asp Ile Met 
        355                 360                 365             


Leu Gly Val Asn Gln Gly Glu Gly Leu Lys Phe Val Asp Gly Ile Val 
    370                 375                 380                 


Asp Asn Glu Asp Gly Val Thr Pro Asn Asp Phe Asp Phe Ser Val Ser 
385                 390                 395                 400 


Asn Phe Val Asp Asn Leu Tyr Gly Tyr Pro Glu Gly Lys Asp Thr Leu 
                405                 410                 415     


Arg Glu Thr Ile Lys Phe Met Tyr Thr Asp Trp Ala Asp Lys Glu Asn 
            420                 425                 430         


Pro Glu Thr Arg Arg Lys Thr Leu Val Ala Leu Phe Thr Asp His Gln 
        435                 440                 445             


Trp Val Ala Pro Ala Val Ala Thr Ala Asp Leu His Ala Gln Tyr Gly 
    450                 455                 460                 


Ser Pro Thr Tyr Phe Tyr Ala Phe Tyr His His Cys Gln Ser Glu Met 
465                 470                 475                 480 


Lys Pro Ser Trp Ala Asp Ser Ala His Gly Asp Glu Val Pro Tyr Val 
                485                 490                 495     


Phe Gly Ile Pro Met Ile Gly Pro Thr Glu Leu Phe Ser Cys Asn Phe 
            500                 505                 510         


Ser Lys Asn Asp Val Met Leu Ser Ala Val Val Met Thr Tyr Trp Thr 
        515                 520                 525             


Asn Phe Ala Lys Thr Gly Asp Pro Asn Gln Pro Val Pro Gln Asp Thr 
    530                 535                 540                 


Lys Phe Ile His Thr Lys Pro Asn Arg Phe Glu Glu Val Ala Trp Ser 
545                 550                 555                 560 


Lys Tyr Asn Pro Lys Asp Gln Leu Tyr Leu His Ile Gly Leu Lys Pro 
                565                 570                 575     


Arg Val Arg Asp His Tyr Arg Ala Thr Lys Val Ala Phe Trp Leu Glu 
            580                 585                 590         


Leu Val Pro His Leu His Asn Leu Asn Glu Ile Phe Gln Tyr Val Ser 
        595                 600                 605             


Thr Thr Thr Lys Val Pro Pro Pro Asp Met Thr Ser Phe Pro Tyr Gly 
    610                 615                 620                 


Thr Arg Arg Ser Pro Ala Lys Ile Trp Pro Thr Thr Lys Arg Pro Ala 
625                 630                 635                 640 


Ile Thr Pro Ala Asn Asn Pro Lys His Ser Lys Asp Pro His Lys Thr 
                645                 650                 655     


Gly Pro Glu Asp Thr Thr Val Leu Ile Glu Thr Lys Arg Asp Tyr Ser 
            660                 665                 670         


Thr Glu Leu Ser Val Thr Ile Ala Val Gly Ala Ser Leu Leu Phe Leu 
        675                 680                 685             


Asn Ile Leu Ala Phe Ala Ala Leu Tyr Tyr Lys Lys Asp Lys Arg Arg 
    690                 695                 700                 


His Glu Thr His Arg Arg Pro Ser Pro Gln Arg Asn Thr Thr Asn Asp 
705                 710                 715                 720 


Ile Ala His Ile Gln Asn Glu Glu Ile Met Ser Leu Gln Met Lys Gln 
                725                 730                 735     


Leu Glu His Asp His Glu Cys Glu Ser Leu Gln Ala His Asp Thr Leu 
            740                 745                 750         


Arg Leu Thr Cys Pro Pro Asp Tyr Thr Leu Thr Leu Arg Arg Ser Pro 
        755                 760                 765             


Asp Asp Ile Pro Leu Met Thr Pro Asn Thr Ile Thr Met Ile Pro Asn 
    770                 775                 780                 


Thr Leu Thr Gly Met Gln Pro Leu His Thr Phe Asn Thr Phe Ser Gly 
785                 790                 795                 800 


Gly Gln Asn Ser Thr Asn Leu Pro His Gly His Ser Thr Thr Arg Val 
                805                 810                 815     

<210>  3667
<211>  6182
<212>  DNA
<213>  Homo sapiens

<400>  3667
cttgcagaac cgtctctctc ccttctctgt ctcttagcac agagctctta ttcagccact     60

agcttggccc ttcctgcttc aattgtaatg cttgttctgc ccgtccacag actattggcg    120

gcagaaacaa cgaatttcct ccaaactagg cggtgttggt ggctcttgca ttcctctgga    180

tgaggaaatc tagttggggg gttccagaag gggaaggctc ctgggctttc aatacatcct    240

cctgaatcat acctcgtttc gggttcccta gaaaaatctg gacgtgtaaa aagaactctt    300

aacggccgat gcagctcttc caaagctaag ggaccattcc cctccaaaat cctacaaggt    360

gggtccatga catctgctag agaaaaagag ggacatgttg gagcgatagg attcccatgg    420

gcactgacat actggcctct ggggatagga agattaatgc ttagtacaag aaagaaggaa    480

aagaaggcct tggcgaggac tgttttatct cagcatttct cagaagctcc ttcagtggag    540

acttcgcctg ggaccttcgc cccaccttct tctaatggca cttcctccct gtggggctcc    600

acgcgggaca ttacgtcggt gatgcgtagg gcatcgggct gccttggagt tttcataaga    660

aattgtccct ggaggtgttg gatgatcaca gcttccttgg agcattgcag ttgctggaat    720

ccagtttcag gattaaggga gggctgcctc cttgcaatgg gctgccaaga aaacggctgt    780

gcttgttctt aacctcaggc tctgtctgtg atcagtctga gagtctctcc caggtctact    840

gctccctgga aagccctatc tctctgcagg ctcgcctctg ggctttgtct ccttggagcc    900

acatcactgg gacagctgtg gatgtggatg cagatttgaa ccatgtcacg gccccaggga    960

ctgctatggc ttcctttgtt gttcaccccg gtctgcgtca tgttaaactc caatgtcctc   1020

ctgtggttaa ctgctcttgc catcaagttc accctcattg acagccaagc acagtatcca   1080

gttgtcaaca caaattatgg caaaatccgg ggcctaagaa caccgttacc caatgagatc   1140

ttgggtccag tggagcagta cttaggggtc ccctatgcct caccccccac tggagagagg   1200

cggtttcagc ccccagaacc cccgtcctcc tggactggca tccgaaatac tactcagttt   1260

gctgctgtgt gcccccagca cctggatgag agatccttac tgcatgacat gctgcccatc   1320

tggtttaccg ccaatttgga tactttgatg acctatgttc aagatcaaaa tgaagactgc   1380

ctttacttaa acatctacgt gcccacggaa gatgatattc atgatcagaa cagtaagaag   1440

cccgtcatgg tctatatcca tgggggatct tacatggagg gcaccggcaa catgattgac   1500

ggcagcattt tggcaagcta cggaaacgtc atcgtgatca ccattaacta ccgtctggga   1560

atactagggt ttttaagtac cggtgaccag gcagcaaaag gcaactatgg gctcctggat   1620

cagattcaag cactgcggtg gattgaggag aatgtgggag cctttggcgg ggaccccaag   1680

agagtgacca tctttggctc gggggctggg gcctcctgtg tcagcctgtt gaccctgtcc   1740

cactactcag aaggtctctt ccagaaggcc atcattcaga gcggcaccgc cctgtccagc   1800

tgggcagtga actaccagcc ggccaagtac actcggatat tggcagacaa ggtcggctgc   1860

aacatgctgg acaccacgga catggtagaa tgcctgcgga acaagaacta caaggagctc   1920

atccagcaga ccatcacccc ggccacctac cacatagcct tcgggccggt gatcgacggc   1980

gacgtcatcc cagacgaccc ccagatcctg atggagcaag gcgagttcct caactacgac   2040

atcatgctgg gcgtcaacca aggggaaggc ctgaagttcg tggacggcat cgtggataac   2100

gaggacggtg tgacgcccaa cgactttgac ttctccgtgt ccaacttcgt ggacaacctt   2160

tacggctacc ctgaagggaa agacactttg cgggagacta tcaagttcat gtacacagac   2220

tgggccgata aggaaaaccc ggagacgcgg cggaaaaccc tggtggctct ctttactgac   2280

caccagtggg tggcccccgc cgtggccacc gccgacctgc acgcgcagta cggctccccc   2340

acctacttct atgccttcta tcatcactgc caaagcgaaa tgaagcccag ctgggcagat   2400

tcggcccatg gtgatgaggt cccctatgtc ttcggcatcc ccatgatcgg tcccaccgag   2460

ctcttcagtt gtaacttttc caagaacgac gtcatgctca gcgccgtggt catgacctac   2520

tggacgaact tcgccaaaac tggtgatcca aatcaaccag ttcctcagga taccaagttc   2580

attcacacaa aacccaaccg ctttgaagaa gtggcctggt ccaagtataa tcccaaagac   2640

cagctctatc tgcatattgg cttgaaaccc agagtgagag atcactaccg ggcaacgaaa   2700

gtggctttct ggttggaact cgttcctcat ttgcacaact tgaacgagat attccagtat   2760

gtttcaacaa ccacaaaggt tcctccacca gacatgacat catttcccta tggcacccgg   2820

cgatctcccg ccaagatatg gccaaccacc aaacgcccag caatcactcc tgccaacaat   2880

cccaaacact ctaaggaccc tcacaaaaca gggcctgagg acacaactgt cctcattgaa   2940

accaaacgag attattccac cgaattaagt gtcaccattg ccgtcggggc gtcgctcctc   3000

ttcctcaaca tcttagcttt tgcggcgctg tactacaaaa aggacaagag gcgccatgag   3060

actcacaggc gccccagtcc ccagagaaac accacaaatg atatcgctca catccagaac   3120

gaagagatca tgtctctgca gatgaagcag ctggaacacg atcacgagtg tgagtcgctg   3180

caggcacacg acacactgag gctcacctgc ccgccagact acaccctcac gctgcgccgg   3240

tcgccagatg acatcccact tatgacgcca aacaccatca ccatgattcc aaacacactg   3300

acggggatgc agcctttgca cacttttaac accttcagtg gaggacaaaa cagtacaaat   3360

ttaccccacg gacattccac cactagagta tagctttgcc ctatttccct tcctatccct   3420

ctgccctacc cgctcagcaa catagaagag ggaaggaaag agagaaggaa agagagagag   3480

aaagaaagtc tccagaccag gaatgttttt gtcccactga cttaagacaa aaatgcaaaa   3540

aggcagtcat cccatcccgg cagaccctta tcgttggtgt tttccagtat tacaagatca   3600

acttctgacc ctgtgaaatg tgagaagtac acatttctgt taaaataact gctttaagat   3660

ctctaccact ccaatcgatg tttagtgtga taggacatca ccatttcaag gccccgggtg   3720

tttccaacgt catggaagca gctgacactt ctgaaactca gccaaggaca cttgatattt   3780

tttaattaca atggaagttt aaacatttct ttctgtgcca cacaatggat ggctctcctt   3840

aagtgaagaa agagtcaatg agattttgcc cagcacatgg agctgtaatc cagagagaag   3900

gaaacgtaga aatttattat taaaagaatg gactgtgcag cgaaatctgt acggttctgt   3960

gcaaagaggt gttttgccag cctgaactat atttaagaga ctttgtaaaa aagaaaaatg   4020

tatatagctg tgagtttaaa caaaaaccac aaacagacaa acaagaaaaa aagcttttat   4080

tggtgttttc actttgaaag agcttttagc aaggttgtgc ttttcattgt gctctgtacg   4140

tatataaata tatatatata tacacacaca cacacacatt agtcatatca cctctgtttc   4200

ctccccaaca aaagaggctt ttcttcttaa ttacttgtgg taaacaaaga catgggattt   4260

tcttacatga gattctcatt tgtaggagga tgtgatgtcc cacagaagac ccagacggtc   4320

tgtgtggcct atttcccccg tcaggttgca caggtgcatg caagagcatt cttaggagac   4380

cactgttttg aaaaactttt gacttgtacg tgttagcctt catgaaattg cagtacagag   4440

atgggtcccc aaagtggagt gtatttacag cttgttaaat tagagacatg cacacacaaa   4500

gaatcagtag ggagaaacaa aaatacaagt cccgttctgt agctctggcc ctttgaatat   4560

gtttaggaag agttgcttcc catttcaggg ccctgccaaa aaaagaagaa agcttgcctt   4620

tggtggggct atgccccttg gagtaaatac ggctctgtgt tccctagcag ctgcgggagg   4680

gtttggccga tgaagtacct gctcagctta gctaatcaga ttgaaggaag acatgtgtct   4740

ttcctttttg tttaagcact cggtccctta tttatcagta agcaggtttt taaaaatctt   4800

ttatatcatt tatgggatca aacatatgat tgtctgaaaa catcactttt tgtggatttg   4860

tgtatccggt caccaaacgg tgaatattat agaagaatgg gggaagaaag gatagaatat   4920

taaaactgct ttgcatgggt tttctgggaa attaggataa cttcactgag aagacattga   4980

atggaaatta ttcacccatt ttaaattggt gacctaggga tcagagattt gtctttccaa   5040

cagcttgtca ttttttcatt tctcttctca tttttcagga aagttttgag tgttataagg   5100

tggaaggaaa catagtagca atggatactt ttttgaaaaa ttattgcatt accaagaaac   5160

agtagccaaa gatatttgaa gatcatgttc ctcggctcca ttgtgggtta ttctagaaat   5220

ccagtcttaa atctctccgc taaagtggac attccccata aaaattgtcc agctgcctgg   5280

ctcttttgca ataacaacct ttgattactg aatccctaca ctcaaactat agtgatatat   5340

cagtgtttga gagtgacctc tagaaaaaag aaaagtgttt ttagaaatgc gtacaagtca   5400

cccccaaatc ctattgctta tcttgggtta aatttgagag tgattctctg tatataaata   5460

tgtgaaatat tattatctca acttagcaca cgtgaagcaa catttctttc ctacagagag   5520

gtgtcatggt aagatttcat tccgaattca ttgtttcata gagctatgat caggccattt   5580

ctgcaagcaa tgtatgaccc cacctgagca accacaaata ggctctctgt gaaactacaa   5640

aggaagttat gtgtggcatc catgttggtt tcgtctgtct gtaatgtgaa ttccagtatt   5700

tgtttagtat ttccagttgt ctcctgctag caatatgtac agtaacgcgt caggcttgtg   5760

acatttgaat aaggaaaaac agagttcctg ttaagtgaat aactttagct tttacagggg   5820

attatgatca aaagtgattt tagtacatct taaatgatat cttatttcta catggaaaga   5880

agttatagaa tcttcataga gttctatgag aaaaaatata cttgctatct ataaaaaaga   5940

gaaaaaagaa aaaaaatgag aaaaaagtaa gaaaaaaaaa aatcctgtcc taggctttta   6000

ctcttgatct tcaaaggcac gcagggttta atggttcctt gggttattat tttgcagttt   6060

tgttttttat tttgccttaa gtaatgatag aagatatata tggccggaca catatgtata   6120

aacttttcag cagcattttt aataataaaa tatcacagta ttttctaatg ctttgtgcaa   6180

at                                                                  6182


<210>  3668
<211>  816
<212>  PRT
<213>  Homo sapiens

<400>  3668


Met Ser Arg Pro Gln Gly Leu Leu Trp Leu Pro Leu Leu Phe Thr Pro 
1               5                   10                  15      


Val Cys Val Met Leu Asn Ser Asn Val Leu Leu Trp Leu Thr Ala Leu 
            20                  25                  30          


Ala Ile Lys Phe Thr Leu Ile Asp Ser Gln Ala Gln Tyr Pro Val Val 
        35                  40                  45              


Asn Thr Asn Tyr Gly Lys Ile Arg Gly Leu Arg Thr Pro Leu Pro Asn 
    50                  55                  60                  


Glu Ile Leu Gly Pro Val Glu Gln Tyr Leu Gly Val Pro Tyr Ala Ser 
65                  70                  75                  80  


Pro Pro Thr Gly Glu Arg Arg Phe Gln Pro Pro Glu Pro Pro Ser Ser 
                85                  90                  95      


Trp Thr Gly Ile Arg Asn Thr Thr Gln Phe Ala Ala Val Cys Pro Gln 
            100                 105                 110         


His Leu Asp Glu Arg Ser Leu Leu His Asp Met Leu Pro Ile Trp Phe 
        115                 120                 125             


Thr Ala Asn Leu Asp Thr Leu Met Thr Tyr Val Gln Asp Gln Asn Glu 
    130                 135                 140                 


Asp Cys Leu Tyr Leu Asn Ile Tyr Val Pro Thr Glu Asp Asp Ile His 
145                 150                 155                 160 


Asp Gln Asn Ser Lys Lys Pro Val Met Val Tyr Ile His Gly Gly Ser 
                165                 170                 175     


Tyr Met Glu Gly Thr Gly Asn Met Ile Asp Gly Ser Ile Leu Ala Ser 
            180                 185                 190         


Tyr Gly Asn Val Ile Val Ile Thr Ile Asn Tyr Arg Leu Gly Ile Leu 
        195                 200                 205             


Gly Phe Leu Ser Thr Gly Asp Gln Ala Ala Lys Gly Asn Tyr Gly Leu 
    210                 215                 220                 


Leu Asp Gln Ile Gln Ala Leu Arg Trp Ile Glu Glu Asn Val Gly Ala 
225                 230                 235                 240 


Phe Gly Gly Asp Pro Lys Arg Val Thr Ile Phe Gly Ser Gly Ala Gly 
                245                 250                 255     


Ala Ser Cys Val Ser Leu Leu Thr Leu Ser His Tyr Ser Glu Gly Leu 
            260                 265                 270         


Phe Gln Lys Ala Ile Ile Gln Ser Gly Thr Ala Leu Ser Ser Trp Ala 
        275                 280                 285             


Val Asn Tyr Gln Pro Ala Lys Tyr Thr Arg Ile Leu Ala Asp Lys Val 
    290                 295                 300                 


Gly Cys Asn Met Leu Asp Thr Thr Asp Met Val Glu Cys Leu Arg Asn 
305                 310                 315                 320 


Lys Asn Tyr Lys Glu Leu Ile Gln Gln Thr Ile Thr Pro Ala Thr Tyr 
                325                 330                 335     


His Ile Ala Phe Gly Pro Val Ile Asp Gly Asp Val Ile Pro Asp Asp 
            340                 345                 350         


Pro Gln Ile Leu Met Glu Gln Gly Glu Phe Leu Asn Tyr Asp Ile Met 
        355                 360                 365             


Leu Gly Val Asn Gln Gly Glu Gly Leu Lys Phe Val Asp Gly Ile Val 
    370                 375                 380                 


Asp Asn Glu Asp Gly Val Thr Pro Asn Asp Phe Asp Phe Ser Val Ser 
385                 390                 395                 400 


Asn Phe Val Asp Asn Leu Tyr Gly Tyr Pro Glu Gly Lys Asp Thr Leu 
                405                 410                 415     


Arg Glu Thr Ile Lys Phe Met Tyr Thr Asp Trp Ala Asp Lys Glu Asn 
            420                 425                 430         


Pro Glu Thr Arg Arg Lys Thr Leu Val Ala Leu Phe Thr Asp His Gln 
        435                 440                 445             


Trp Val Ala Pro Ala Val Ala Thr Ala Asp Leu His Ala Gln Tyr Gly 
    450                 455                 460                 


Ser Pro Thr Tyr Phe Tyr Ala Phe Tyr His His Cys Gln Ser Glu Met 
465                 470                 475                 480 


Lys Pro Ser Trp Ala Asp Ser Ala His Gly Asp Glu Val Pro Tyr Val 
                485                 490                 495     


Phe Gly Ile Pro Met Ile Gly Pro Thr Glu Leu Phe Ser Cys Asn Phe 
            500                 505                 510         


Ser Lys Asn Asp Val Met Leu Ser Ala Val Val Met Thr Tyr Trp Thr 
        515                 520                 525             


Asn Phe Ala Lys Thr Gly Asp Pro Asn Gln Pro Val Pro Gln Asp Thr 
    530                 535                 540                 


Lys Phe Ile His Thr Lys Pro Asn Arg Phe Glu Glu Val Ala Trp Ser 
545                 550                 555                 560 


Lys Tyr Asn Pro Lys Asp Gln Leu Tyr Leu His Ile Gly Leu Lys Pro 
                565                 570                 575     


Arg Val Arg Asp His Tyr Arg Ala Thr Lys Val Ala Phe Trp Leu Glu 
            580                 585                 590         


Leu Val Pro His Leu His Asn Leu Asn Glu Ile Phe Gln Tyr Val Ser 
        595                 600                 605             


Thr Thr Thr Lys Val Pro Pro Pro Asp Met Thr Ser Phe Pro Tyr Gly 
    610                 615                 620                 


Thr Arg Arg Ser Pro Ala Lys Ile Trp Pro Thr Thr Lys Arg Pro Ala 
625                 630                 635                 640 


Ile Thr Pro Ala Asn Asn Pro Lys His Ser Lys Asp Pro His Lys Thr 
                645                 650                 655     


Gly Pro Glu Asp Thr Thr Val Leu Ile Glu Thr Lys Arg Asp Tyr Ser 
            660                 665                 670         


Thr Glu Leu Ser Val Thr Ile Ala Val Gly Ala Ser Leu Leu Phe Leu 
        675                 680                 685             


Asn Ile Leu Ala Phe Ala Ala Leu Tyr Tyr Lys Lys Asp Lys Arg Arg 
    690                 695                 700                 


His Glu Thr His Arg Arg Pro Ser Pro Gln Arg Asn Thr Thr Asn Asp 
705                 710                 715                 720 


Ile Ala His Ile Gln Asn Glu Glu Ile Met Ser Leu Gln Met Lys Gln 
                725                 730                 735     


Leu Glu His Asp His Glu Cys Glu Ser Leu Gln Ala His Asp Thr Leu 
            740                 745                 750         


Arg Leu Thr Cys Pro Pro Asp Tyr Thr Leu Thr Leu Arg Arg Ser Pro 
        755                 760                 765             


Asp Asp Ile Pro Leu Met Thr Pro Asn Thr Ile Thr Met Ile Pro Asn 
    770                 775                 780                 


Thr Leu Thr Gly Met Gln Pro Leu His Thr Phe Asn Thr Phe Ser Gly 
785                 790                 795                 800 


Gly Gln Asn Ser Thr Asn Leu Pro His Gly His Ser Thr Thr Arg Val 
                805                 810                 815     

<210>  3669
<211>  6050
<212>  DNA
<213>  Homo sapiens

<400>  3669
attgggatta gcagctcttt gcatgaggtt gtagctgtgg atgtggtttc tgtagtgatg     60

gggccgactc cggagatcta ttggctgctg gctttgtaaa tttcattcag tttggtccaa    120

tggcagaggg agagccccgg agacagcagg acctctctcc tcaatctctc tttttcttgc    180

agaaccgtct ctctcccttc tctgtctctt agcacagagc tcttattcag ccactagctt    240

ggcccttcct gcttcaattg taatgcttgt tctgcccgtc cacagactat tggcggcaga    300

aacaacgaat ttcctccaaa ctaggcggtg ttggtggctc ttgcattcct ctggatgagg    360

aaatctagtt ggggggttcc agaaggggaa ggctcctggg ctttcaatac atcctcctga    420

atcatacctc gtttcgggtt ccctagaaaa atctggacgt gtaaaaagaa ctcttaacgg    480

ccgatgcagc tcttccaaag ctaaggctgc cttggagttt tcataagaaa ttgtccctgg    540

aggtgttgga tgatcacagc ttccttggag cattgcagtt gctggaatcc agtttcagga    600

ttaagggagg gctgcctcct tgcaatgggc tgccaagaaa acggctgtgc ttgttcttaa    660

cctcaggctc tgtctgtgat cagtctgaga gtctctccca ggtctactgc tccctggaaa    720

gccctatctc tctgcaggct cgcctctggg ctttgtctcc ttggagccac atcactggga    780

cagctgtgga tgtggatgca gatttgaacc atgtcacggc cccagggact gctatggctt    840

cctttgttgt tcaccccggt ctgcgtcatg ttaaactcca atgtcctcct gtggttaact    900

gctcttgcca tcaagttcac cctcattgac agccaagcac agtatccagt tgtcaacaca    960

aattatggca aaatccgggg cctaagaaca ccgttaccca atgagatctt gggtccagtg   1020

gagcagtact taggggtccc ctatgcctca ccccccactg gagagaggcg gtttcagccc   1080

ccagaacccc cgtcctcctg gactggcatc cgaaatacta ctcagtttgc tgctgtgtgc   1140

ccccagcacc tggatgagag atccttactg catgacatgc tgcccatctg gtttaccgcc   1200

aatttggata ctttgatgac ctatgttcaa gatcaaaatg aagactgcct ttacttaaac   1260

atctacgtgc ccacggaaga tgatattcat gatcagaaca gtaagaagcc cgtcatggtc   1320

tatatccatg ggggatctta catggagggc accggcaaca tgattgacgg cagcattttg   1380

gcaagctacg gaaacgtcat cgtgatcacc attaactacc gtctgggaat actagggttt   1440

ttaagtaccg gtgaccaggc agcaaaaggc aactatgggc tcctggatca gattcaagca   1500

ctgcggtgga ttgaggagaa tgtgggagcc tttggcgggg accccaagag agtgaccatc   1560

tttggctcgg gggctggggc ctcctgtgtc agcctgttga ccctgtccca ctactcagaa   1620

ggtctcttcc agaaggccat cattcagagc ggcaccgccc tgtccagctg ggcagtgaac   1680

taccagccgg ccaagtacac tcggatattg gcagacaagg tcggctgcaa catgctggac   1740

accacggaca tggtagaatg cctgcggaac aagaactaca aggagctcat ccagcagacc   1800

atcaccccgg ccacctacca catagccttc gggccggtga tcgacggcga cgtcatccca   1860

gacgaccccc agatcctgat ggagcaaggc gagttcctca actacgacat catgctgggc   1920

gtcaaccaag gggaaggcct gaagttcgtg gacggcatcg tggataacga ggacggtgtg   1980

acgcccaacg actttgactt ctccgtgtcc aacttcgtgg acaaccttta cggctaccct   2040

gaagggaaag acactttgcg ggagactatc aagttcatgt acacagactg ggccgataag   2100

gaaaacccgg agacgcggcg gaaaaccctg gtggctctct ttactgacca ccagtgggtg   2160

gcccccgccg tggccaccgc cgacctgcac gcgcagtacg gctcccccac ctacttctat   2220

gccttctatc atcactgcca aagcgaaatg aagcccagct gggcagattc ggcccatggt   2280

gatgaggtcc cctatgtctt cggcatcccc atgatcggtc ccaccgagct cttcagttgt   2340

aacttttcca agaacgacgt catgctcagc gccgtggtca tgacctactg gacgaacttc   2400

gccaaaactg gtgatccaaa tcaaccagtt cctcaggata ccaagttcat tcacacaaaa   2460

cccaaccgct ttgaagaagt ggcctggtcc aagtataatc ccaaagacca gctctatctg   2520

catattggct tgaaacccag agtgagagat cactaccggg caacgaaagt ggctttctgg   2580

ttggaactcg ttcctcattt gcacaacttg aacgagatat tccagtatgt ttcaacaacc   2640

acaaaggttc ctccaccaga catgacatca tttccctatg gcacccggcg atctcccgcc   2700

aagatatggc caaccaccaa acgcccagca atcactcctg ccaacaatcc caaacactct   2760

aaggaccctc acaaaacagg gcctgaggac acaactgtcc tcattgaaac caaacgagat   2820

tattccaccg aattaagtgt caccattgcc gtcggggcgt cgctcctctt cctcaacatc   2880

ttagcttttg cggcgctgta ctacaaaaag gacaagaggc gccatgagac tcacaggcgc   2940

cccagtcccc agagaaacac cacaaatgat atcgctcaca tccagaacga agagatcatg   3000

tctctgcaga tgaagcagct ggaacacgat cacgagtgtg agtcgctgca ggcacacgac   3060

acactgaggc tcacctgccc gccagactac accctcacgc tgcgccggtc gccagatgac   3120

atcccactta tgacgccaaa caccatcacc atgattccaa acacactgac ggggatgcag   3180

cctttgcaca cttttaacac cttcagtgga ggacaaaaca gtacaaattt accccacgga   3240

cattccacca ctagagtata gctttgccct atttcccttc ctatccctct gccctacccg   3300

ctcagcaaca tagaagaggg aaggaaagag agaaggaaag agagagagaa agaaagtctc   3360

cagaccagga atgtttttgt cccactgact taagacaaaa atgcaaaaag gcagtcatcc   3420

catcccggca gacccttatc gttggtgttt tccagtatta caagatcaac ttctgaccct   3480

gtgaaatgtg agaagtacac atttctgtta aaataactgc tttaagatct ctaccactcc   3540

aatcgatgtt tagtgtgata ggacatcacc atttcaaggc cccgggtgtt tccaacgtca   3600

tggaagcagc tgacacttct gaaactcagc caaggacact tgatattttt taattacaat   3660

ggaagtttaa acatttcttt ctgtgccaca caatggatgg ctctccttaa gtgaagaaag   3720

agtcaatgag attttgccca gcacatggag ctgtaatcca gagagaagga aacgtagaaa   3780

tttattatta aaagaatgga ctgtgcagcg aaatctgtac ggttctgtgc aaagaggtgt   3840

tttgccagcc tgaactatat ttaagagact ttgtaaaaaa gaaaaatgta tatagctgtg   3900

agtttaaaca aaaaccacaa acagacaaac aagaaaaaaa gcttttattg gtgttttcac   3960

tttgaaagag cttttagcaa ggttgtgctt ttcattgtgc tctgtacgta tataaatata   4020

tatatatata cacacacaca cacacattag tcatatcacc tctgtttcct ccccaacaaa   4080

agaggctttt cttcttaatt acttgtggta aacaaagaca tgggattttc ttacatgaga   4140

ttctcatttg taggaggatg tgatgtccca cagaagaccc agacggtctg tgtggcctat   4200

ttcccccgtc aggttgcaca ggtgcatgca agagcattct taggagacca ctgttttgaa   4260

aaacttttga cttgtacgtg ttagccttca tgaaattgca gtacagagat gggtccccaa   4320

agtggagtgt atttacagct tgttaaatta gagacatgca cacacaaaga atcagtaggg   4380

agaaacaaaa atacaagtcc cgttctgtag ctctggccct ttgaatatgt ttaggaagag   4440

ttgcttccca tttcagggcc ctgccaaaaa aagaagaaag cttgcctttg gtggggctat   4500

gccccttgga gtaaatacgg ctctgtgttc cctagcagct gcgggagggt ttggccgatg   4560

aagtacctgc tcagcttagc taatcagatt gaaggaagac atgtgtcttt cctttttgtt   4620

taagcactcg gtcccttatt tatcagtaag caggttttta aaaatctttt atatcattta   4680

tgggatcaaa catatgattg tctgaaaaca tcactttttg tggatttgtg tatccggtca   4740

ccaaacggtg aatattatag aagaatgggg gaagaaagga tagaatatta aaactgcttt   4800

gcatgggttt tctgggaaat taggataact tcactgagaa gacattgaat ggaaattatt   4860

cacccatttt aaattggtga cctagggatc agagatttgt ctttccaaca gcttgtcatt   4920

ttttcatttc tcttctcatt tttcaggaaa gttttgagtg ttataaggtg gaaggaaaca   4980

tagtagcaat ggatactttt ttgaaaaatt attgcattac caagaaacag tagccaaaga   5040

tatttgaaga tcatgttcct cggctccatt gtgggttatt ctagaaatcc agtcttaaat   5100

ctctccgcta aagtggacat tccccataaa aattgtccag ctgcctggct cttttgcaat   5160

aacaaccttt gattactgaa tccctacact caaactatag tgatatatca gtgtttgaga   5220

gtgacctcta gaaaaaagaa aagtgttttt agaaatgcgt acaagtcacc cccaaatcct   5280

attgcttatc ttgggttaaa tttgagagtg attctctgta tataaatatg tgaaatatta   5340

ttatctcaac ttagcacacg tgaagcaaca tttctttcct acagagaggt gtcatggtaa   5400

gatttcattc cgaattcatt gtttcataga gctatgatca ggccatttct gcaagcaatg   5460

tatgacccca cctgagcaac cacaaatagg ctctctgtga aactacaaag gaagttatgt   5520

gtggcatcca tgttggtttc gtctgtctgt aatgtgaatt ccagtatttg tttagtattt   5580

ccagttgtct cctgctagca atatgtacag taacgcgtca ggcttgtgac atttgaataa   5640

ggaaaaacag agttcctgtt aagtgaataa ctttagcttt tacaggggat tatgatcaaa   5700

agtgatttta gtacatctta aatgatatct tatttctaca tggaaagaag ttatagaatc   5760

ttcatagagt tctatgagaa aaaatatact tgctatctat aaaaaagaga aaaaagaaaa   5820

aaaatgagaa aaaagtaaga aaaaaaaaaa tcctgtccta ggcttttact cttgatcttc   5880

aaaggcacgc agggtttaat ggttccttgg gttattattt tgcagttttg ttttttattt   5940

tgccttaagt aatgatagaa gatatatatg gccggacaca tatgtataaa cttttcagca   6000

gcatttttaa taataaaata tcacagtatt ttctaatgct ttgtgcaaat              6050


<210>  3670
<211>  816
<212>  PRT
<213>  Homo sapiens

<400>  3670


Met Ser Arg Pro Gln Gly Leu Leu Trp Leu Pro Leu Leu Phe Thr Pro 
1               5                   10                  15      


Val Cys Val Met Leu Asn Ser Asn Val Leu Leu Trp Leu Thr Ala Leu 
            20                  25                  30          


Ala Ile Lys Phe Thr Leu Ile Asp Ser Gln Ala Gln Tyr Pro Val Val 
        35                  40                  45              


Asn Thr Asn Tyr Gly Lys Ile Arg Gly Leu Arg Thr Pro Leu Pro Asn 
    50                  55                  60                  


Glu Ile Leu Gly Pro Val Glu Gln Tyr Leu Gly Val Pro Tyr Ala Ser 
65                  70                  75                  80  


Pro Pro Thr Gly Glu Arg Arg Phe Gln Pro Pro Glu Pro Pro Ser Ser 
                85                  90                  95      


Trp Thr Gly Ile Arg Asn Thr Thr Gln Phe Ala Ala Val Cys Pro Gln 
            100                 105                 110         


His Leu Asp Glu Arg Ser Leu Leu His Asp Met Leu Pro Ile Trp Phe 
        115                 120                 125             


Thr Ala Asn Leu Asp Thr Leu Met Thr Tyr Val Gln Asp Gln Asn Glu 
    130                 135                 140                 


Asp Cys Leu Tyr Leu Asn Ile Tyr Val Pro Thr Glu Asp Asp Ile His 
145                 150                 155                 160 


Asp Gln Asn Ser Lys Lys Pro Val Met Val Tyr Ile His Gly Gly Ser 
                165                 170                 175     


Tyr Met Glu Gly Thr Gly Asn Met Ile Asp Gly Ser Ile Leu Ala Ser 
            180                 185                 190         


Tyr Gly Asn Val Ile Val Ile Thr Ile Asn Tyr Arg Leu Gly Ile Leu 
        195                 200                 205             


Gly Phe Leu Ser Thr Gly Asp Gln Ala Ala Lys Gly Asn Tyr Gly Leu 
    210                 215                 220                 


Leu Asp Gln Ile Gln Ala Leu Arg Trp Ile Glu Glu Asn Val Gly Ala 
225                 230                 235                 240 


Phe Gly Gly Asp Pro Lys Arg Val Thr Ile Phe Gly Ser Gly Ala Gly 
                245                 250                 255     


Ala Ser Cys Val Ser Leu Leu Thr Leu Ser His Tyr Ser Glu Gly Leu 
            260                 265                 270         


Phe Gln Lys Ala Ile Ile Gln Ser Gly Thr Ala Leu Ser Ser Trp Ala 
        275                 280                 285             


Val Asn Tyr Gln Pro Ala Lys Tyr Thr Arg Ile Leu Ala Asp Lys Val 
    290                 295                 300                 


Gly Cys Asn Met Leu Asp Thr Thr Asp Met Val Glu Cys Leu Arg Asn 
305                 310                 315                 320 


Lys Asn Tyr Lys Glu Leu Ile Gln Gln Thr Ile Thr Pro Ala Thr Tyr 
                325                 330                 335     


His Ile Ala Phe Gly Pro Val Ile Asp Gly Asp Val Ile Pro Asp Asp 
            340                 345                 350         


Pro Gln Ile Leu Met Glu Gln Gly Glu Phe Leu Asn Tyr Asp Ile Met 
        355                 360                 365             


Leu Gly Val Asn Gln Gly Glu Gly Leu Lys Phe Val Asp Gly Ile Val 
    370                 375                 380                 


Asp Asn Glu Asp Gly Val Thr Pro Asn Asp Phe Asp Phe Ser Val Ser 
385                 390                 395                 400 


Asn Phe Val Asp Asn Leu Tyr Gly Tyr Pro Glu Gly Lys Asp Thr Leu 
                405                 410                 415     


Arg Glu Thr Ile Lys Phe Met Tyr Thr Asp Trp Ala Asp Lys Glu Asn 
            420                 425                 430         


Pro Glu Thr Arg Arg Lys Thr Leu Val Ala Leu Phe Thr Asp His Gln 
        435                 440                 445             


Trp Val Ala Pro Ala Val Ala Thr Ala Asp Leu His Ala Gln Tyr Gly 
    450                 455                 460                 


Ser Pro Thr Tyr Phe Tyr Ala Phe Tyr His His Cys Gln Ser Glu Met 
465                 470                 475                 480 


Lys Pro Ser Trp Ala Asp Ser Ala His Gly Asp Glu Val Pro Tyr Val 
                485                 490                 495     


Phe Gly Ile Pro Met Ile Gly Pro Thr Glu Leu Phe Ser Cys Asn Phe 
            500                 505                 510         


Ser Lys Asn Asp Val Met Leu Ser Ala Val Val Met Thr Tyr Trp Thr 
        515                 520                 525             


Asn Phe Ala Lys Thr Gly Asp Pro Asn Gln Pro Val Pro Gln Asp Thr 
    530                 535                 540                 


Lys Phe Ile His Thr Lys Pro Asn Arg Phe Glu Glu Val Ala Trp Ser 
545                 550                 555                 560 


Lys Tyr Asn Pro Lys Asp Gln Leu Tyr Leu His Ile Gly Leu Lys Pro 
                565                 570                 575     


Arg Val Arg Asp His Tyr Arg Ala Thr Lys Val Ala Phe Trp Leu Glu 
            580                 585                 590         


Leu Val Pro His Leu His Asn Leu Asn Glu Ile Phe Gln Tyr Val Ser 
        595                 600                 605             


Thr Thr Thr Lys Val Pro Pro Pro Asp Met Thr Ser Phe Pro Tyr Gly 
    610                 615                 620                 


Thr Arg Arg Ser Pro Ala Lys Ile Trp Pro Thr Thr Lys Arg Pro Ala 
625                 630                 635                 640 


Ile Thr Pro Ala Asn Asn Pro Lys His Ser Lys Asp Pro His Lys Thr 
                645                 650                 655     


Gly Pro Glu Asp Thr Thr Val Leu Ile Glu Thr Lys Arg Asp Tyr Ser 
            660                 665                 670         


Thr Glu Leu Ser Val Thr Ile Ala Val Gly Ala Ser Leu Leu Phe Leu 
        675                 680                 685             


Asn Ile Leu Ala Phe Ala Ala Leu Tyr Tyr Lys Lys Asp Lys Arg Arg 
    690                 695                 700                 


His Glu Thr His Arg Arg Pro Ser Pro Gln Arg Asn Thr Thr Asn Asp 
705                 710                 715                 720 


Ile Ala His Ile Gln Asn Glu Glu Ile Met Ser Leu Gln Met Lys Gln 
                725                 730                 735     


Leu Glu His Asp His Glu Cys Glu Ser Leu Gln Ala His Asp Thr Leu 
            740                 745                 750         


Arg Leu Thr Cys Pro Pro Asp Tyr Thr Leu Thr Leu Arg Arg Ser Pro 
        755                 760                 765             


Asp Asp Ile Pro Leu Met Thr Pro Asn Thr Ile Thr Met Ile Pro Asn 
    770                 775                 780                 


Thr Leu Thr Gly Met Gln Pro Leu His Thr Phe Asn Thr Phe Ser Gly 
785                 790                 795                 800 


Gly Gln Asn Ser Thr Asn Leu Pro His Gly His Ser Thr Thr Arg Val 
                805                 810                 815     

<210>  3671
<211>  4465
<212>  DNA
<213>  Homo sapiens

<400>  3671
attgggatta gcagctcttt gcatgaggtt gtagctgtgg atgtggtttc tgtagtgatg     60

gggccgactc cggagatcta ttggctgctg gctttgtaaa tttcattcag tttggtccaa    120

tggcagaggg agagccccgg agacagcagg acctctctcc tcaatctctc tttttcttgc    180

agaaccgtct ctctcccttc tctgtctctt agcacagagc tcttattcag ccactagctt    240

ggcccttcct gcttcaattg taatgcttgt tctgcccgtc cacagactat tggcggcaga    300

aacaacgaat ttcctccaaa ctaggcggtg ttggtggctc ttgcattcct ctggatgagg    360

aaatctagtt ggggggttcc agaaggggaa ggctcctggg ctttcaatac atcctcctga    420

atcatacctc gtttcgggtt ccctagaaaa atctggacgt gtaaaaagaa ctcttaacgg    480

ccgatgcagc tcttccaaag ctaaggctgc cttggagttt tcataagaaa ttgtccctgg    540

aggtgttgga tgatcacagc ttccttggag cattgcagtt gctggaatcc agtttcagga    600

ttaagggagg gctgcctcct tgcaatgggc tgccaagaaa acggctgtgc ttgttcttaa    660

cctcaggctc tgtctgtgat cagtctgaga gtctctccca ggtctactgc tccctggaaa    720

gccctatctc tctgcaggct cgcctctggg ctttgtctcc ttggagccac atcactggga    780

cagctgtgga tgtggatgca gatttgaacc atgtcacggc cccagggact gctatggctt    840

cctttgttgt tcaccccggt ctgcgtcatg ttaaactcca atgtcctcct gtggttaact    900

gctcttgcca tcaagttcac cctcattgac agccaagcac agtatccagt tgtcaacaca    960

aattatggca aaatccgggg cctaagaaca ccgttaccca atgagatctt gggtccagtg   1020

gagcagtact taggggtccc ctatgcctca ccccccactg gagagaggcg gtttcagccc   1080

ccagaacccc cgtcctcctg gactggcatc cgaaatacta ctcagtttgc tgctgtgtgc   1140

ccccagcacc tggatgagag atccttactg catgacatgc tgcccatctg gtttaccgcc   1200

aatttggata ctttgatgac ctatgttcaa gatcaaaatg aagactgcct ttacttaaac   1260

atctacgtgc ccacggaaga tgatattcat gatcagaaca gtaagaagcc cgtcatggtc   1320

tatatccatg ggggatctta catggagggc accggcaaca tgattgacgg cagcattttg   1380

gcaagctacg gaaacgtcat cgtgatcacc attaactacc gtctgggaat actagggttt   1440

ttaagtaccg gtgaccaggc agcaaaaggc aactatgggc tcctggatca gattcaagca   1500

ctgcggtgga ttgaggagaa tgtgggagcc tttggcgggg accccaagag agtgaccatc   1560

tttggctcgg gggctggggc ctcctgtgtc agcctgttga ccctgtccca ctactcagaa   1620

ggtctcttcc agaaggccat cattcagagc ggcaccgccc tgtccagctg ggcagtgaac   1680

taccagccgg ccaagtacac tcggatattg gcagacaagg tcggctgcaa catgctggac   1740

accacggaca tggtagaatg cctgcggaac aagaactaca aggagctcat ccagcagacc   1800

atcaccccgg ccacctacca catagccttc gggccggtga tcgacggcga cgtcatccca   1860

gacgaccccc agatcctgat ggagcaaggc gagttcctca actacgacat catgctgggc   1920

gtcaaccaag gggaaggcct gaagttcgtg gacggcatcg tggataacga ggacggtgtg   1980

acgcccaacg actttgactt ctccgtgtcc aacttcgtgg acaaccttta cggctaccct   2040

gaagggaaag acactttgcg ggagactatc aagttcatgt acacagactg ggccgataag   2100

gaaaacccgg agacgcggcg gaaaaccctg gtggctctct ttactgacca ccagtgggtg   2160

gcccccgccg tggccaccgc cgacctgcac gcgcagtacg gctcccccac ctacttctat   2220

gccttctatc atcactgcca aagcgaaatg aagcccagct gggcagattc ggcccatggt   2280

gatgaggtcc cctatgtctt cggcatcccc atgatcggtc ccaccgagct cttcagttgt   2340

aacttttcca agaacgacgt catgctcagc gccgtggtca tgacctactg gacgaacttc   2400

gccaaaactg gtgatccaaa tcaaccagtt cctcaggata ccaagttcat tcacacaaaa   2460

cccaaccgct ttgaagaagt ggcctggtcc aagtataatc ccaaagacca gctctatctg   2520

catattggct tgaaacccag agtgagagat cactaccggg caacgaaagt ggctttctgg   2580

ttggaactcg ttcctcattt gcacaacttg aacgagatat tccagtatgt ttcaacaacc   2640

acaaaggttc ctccaccaga catgacatca tttccctatg gcacccggcg atctcccgcc   2700

aagatatggc caaccaccaa acgcccagca atcactcctg ccaacaatcc caaacactct   2760

aaggaccctc acaaaacagg gcctgaggac acaactgtcc tcattgaaac caaacgagat   2820

tattccaccg aattaagtgt caccattgcc gtcggggcgt cgctcctctt cctcaacatc   2880

ttagcttttg cggcgctgta ctacaaaaag gacaagaggc gccatgagac tcacaggcgc   2940

cccagtcccc agagaaacac cacaaatgat atcgctcaca tccagaacga agagatcatg   3000

tctctgcaga tgaagcagct ggaacacgat cacgagtgtg agtcgctgca ggcacacgac   3060

acactgaggc tcacctgccc gccagactac accctcacgc tgcgccggtc gccagatgac   3120

atcccactta tgacgccaaa caccatcacc atgattccaa acacactgac ggggatgcag   3180

cctttgcaca cttttaacac cttcagtgga ggacaaaaca gtacaaattt accccacgga   3240

cattccacca ctagagtata gctttgccct atttcccttc ctatccctct gccctacccg   3300

ctcagcaaca tagaagaggg aaggaaagag agaaggaaag agagagagaa agaaagtctc   3360

cagaccagga atgtttttgt cccactgact taagacaaaa atgcaaaaag gcagtcatcc   3420

catcccggca gacccttatc gttggtgttt tccagtatta caagatcaac ttctgaccct   3480

gtgaaatgtg agaagtacac atttctgtta aaataactgc tttaagatct ctaccactcc   3540

aatcgatgtt tagtgtgata ggacatcacc atttcaaggc cccgggtgtt tccaacgtca   3600

tggaagcagc tgacacttct gaaactcagc caaggacact tgatattttt taattacaat   3660

ggaagtttaa acatttcttt ctgtgccaca caatggatgg ctctccttaa gtgaagaaag   3720

agtcaatgag attttgccca gcacatggag ctgtaatcca gagagaagga aacgtagaaa   3780

tttattatta aaagaatgga ctgtgcagcg aaatctgtac ggttctgtgc aaagaggtgt   3840

tttgccagcc tgaactatat ttaagagact ttgtaaaaaa gaaaaatgta tatagctgtg   3900

agtttaaaca aaaaccacaa acagacaaac aagaaaaaaa gcttttattg gtgttttcac   3960

tttgaaagag cttttagcaa ggttgtgctt ttcattgtgc tctgtacgta tataaatata   4020

tatatatata cacacacaca cacacattag tcatatcacc tctgtttcct ccccaacaaa   4080

agaggctttt cttcttaatt acttgtggta aacaaagaca tgggattttc ttacatgaga   4140

ttctcatttg taggaggatg tgatgtccca cagaagaccc agacggtctg tgtggcctat   4200

ttcccccgtc aggttgcaca ggtgcatgca agagcattct taggagacca ctgttttgaa   4260

aaacttttga cttgtacgtg ttagccttca tgaaattgca gtacagagat gggtccccaa   4320

agtggagtgt atttacagct tgttaaatta gagacatgca cacacaaaga atcagtaggg   4380

agaaacaaaa atacaagtcc cgttctgtag ctctggccct ttgaatatgt ttaggaagag   4440

ttgcttccca tttcagggcc ctgcc                                         4465


<210>  3672
<211>  816
<212>  PRT
<213>  Homo sapiens

<400>  3672


Met Ser Arg Pro Gln Gly Leu Leu Trp Leu Pro Leu Leu Phe Thr Pro 
1               5                   10                  15      


Val Cys Val Met Leu Asn Ser Asn Val Leu Leu Trp Leu Thr Ala Leu 
            20                  25                  30          


Ala Ile Lys Phe Thr Leu Ile Asp Ser Gln Ala Gln Tyr Pro Val Val 
        35                  40                  45              


Asn Thr Asn Tyr Gly Lys Ile Arg Gly Leu Arg Thr Pro Leu Pro Asn 
    50                  55                  60                  


Glu Ile Leu Gly Pro Val Glu Gln Tyr Leu Gly Val Pro Tyr Ala Ser 
65                  70                  75                  80  


Pro Pro Thr Gly Glu Arg Arg Phe Gln Pro Pro Glu Pro Pro Ser Ser 
                85                  90                  95      


Trp Thr Gly Ile Arg Asn Thr Thr Gln Phe Ala Ala Val Cys Pro Gln 
            100                 105                 110         


His Leu Asp Glu Arg Ser Leu Leu His Asp Met Leu Pro Ile Trp Phe 
        115                 120                 125             


Thr Ala Asn Leu Asp Thr Leu Met Thr Tyr Val Gln Asp Gln Asn Glu 
    130                 135                 140                 


Asp Cys Leu Tyr Leu Asn Ile Tyr Val Pro Thr Glu Asp Asp Ile His 
145                 150                 155                 160 


Asp Gln Asn Ser Lys Lys Pro Val Met Val Tyr Ile His Gly Gly Ser 
                165                 170                 175     


Tyr Met Glu Gly Thr Gly Asn Met Ile Asp Gly Ser Ile Leu Ala Ser 
            180                 185                 190         


Tyr Gly Asn Val Ile Val Ile Thr Ile Asn Tyr Arg Leu Gly Ile Leu 
        195                 200                 205             


Gly Phe Leu Ser Thr Gly Asp Gln Ala Ala Lys Gly Asn Tyr Gly Leu 
    210                 215                 220                 


Leu Asp Gln Ile Gln Ala Leu Arg Trp Ile Glu Glu Asn Val Gly Ala 
225                 230                 235                 240 


Phe Gly Gly Asp Pro Lys Arg Val Thr Ile Phe Gly Ser Gly Ala Gly 
                245                 250                 255     


Ala Ser Cys Val Ser Leu Leu Thr Leu Ser His Tyr Ser Glu Gly Leu 
            260                 265                 270         


Phe Gln Lys Ala Ile Ile Gln Ser Gly Thr Ala Leu Ser Ser Trp Ala 
        275                 280                 285             


Val Asn Tyr Gln Pro Ala Lys Tyr Thr Arg Ile Leu Ala Asp Lys Val 
    290                 295                 300                 


Gly Cys Asn Met Leu Asp Thr Thr Asp Met Val Glu Cys Leu Arg Asn 
305                 310                 315                 320 


Lys Asn Tyr Lys Glu Leu Ile Gln Gln Thr Ile Thr Pro Ala Thr Tyr 
                325                 330                 335     


His Ile Ala Phe Gly Pro Val Ile Asp Gly Asp Val Ile Pro Asp Asp 
            340                 345                 350         


Pro Gln Ile Leu Met Glu Gln Gly Glu Phe Leu Asn Tyr Asp Ile Met 
        355                 360                 365             


Leu Gly Val Asn Gln Gly Glu Gly Leu Lys Phe Val Asp Gly Ile Val 
    370                 375                 380                 


Asp Asn Glu Asp Gly Val Thr Pro Asn Asp Phe Asp Phe Ser Val Ser 
385                 390                 395                 400 


Asn Phe Val Asp Asn Leu Tyr Gly Tyr Pro Glu Gly Lys Asp Thr Leu 
                405                 410                 415     


Arg Glu Thr Ile Lys Phe Met Tyr Thr Asp Trp Ala Asp Lys Glu Asn 
            420                 425                 430         


Pro Glu Thr Arg Arg Lys Thr Leu Val Ala Leu Phe Thr Asp His Gln 
        435                 440                 445             


Trp Val Ala Pro Ala Val Ala Thr Ala Asp Leu His Ala Gln Tyr Gly 
    450                 455                 460                 


Ser Pro Thr Tyr Phe Tyr Ala Phe Tyr His His Cys Gln Ser Glu Met 
465                 470                 475                 480 


Lys Pro Ser Trp Ala Asp Ser Ala His Gly Asp Glu Val Pro Tyr Val 
                485                 490                 495     


Phe Gly Ile Pro Met Ile Gly Pro Thr Glu Leu Phe Ser Cys Asn Phe 
            500                 505                 510         


Ser Lys Asn Asp Val Met Leu Ser Ala Val Val Met Thr Tyr Trp Thr 
        515                 520                 525             


Asn Phe Ala Lys Thr Gly Asp Pro Asn Gln Pro Val Pro Gln Asp Thr 
    530                 535                 540                 


Lys Phe Ile His Thr Lys Pro Asn Arg Phe Glu Glu Val Ala Trp Ser 
545                 550                 555                 560 


Lys Tyr Asn Pro Lys Asp Gln Leu Tyr Leu His Ile Gly Leu Lys Pro 
                565                 570                 575     


Arg Val Arg Asp His Tyr Arg Ala Thr Lys Val Ala Phe Trp Leu Glu 
            580                 585                 590         


Leu Val Pro His Leu His Asn Leu Asn Glu Ile Phe Gln Tyr Val Ser 
        595                 600                 605             


Thr Thr Thr Lys Val Pro Pro Pro Asp Met Thr Ser Phe Pro Tyr Gly 
    610                 615                 620                 


Thr Arg Arg Ser Pro Ala Lys Ile Trp Pro Thr Thr Lys Arg Pro Ala 
625                 630                 635                 640 


Ile Thr Pro Ala Asn Asn Pro Lys His Ser Lys Asp Pro His Lys Thr 
                645                 650                 655     


Gly Pro Glu Asp Thr Thr Val Leu Ile Glu Thr Lys Arg Asp Tyr Ser 
            660                 665                 670         


Thr Glu Leu Ser Val Thr Ile Ala Val Gly Ala Ser Leu Leu Phe Leu 
        675                 680                 685             


Asn Ile Leu Ala Phe Ala Ala Leu Tyr Tyr Lys Lys Asp Lys Arg Arg 
    690                 695                 700                 


His Glu Thr His Arg Arg Pro Ser Pro Gln Arg Asn Thr Thr Asn Asp 
705                 710                 715                 720 


Ile Ala His Ile Gln Asn Glu Glu Ile Met Ser Leu Gln Met Lys Gln 
                725                 730                 735     


Leu Glu His Asp His Glu Cys Glu Ser Leu Gln Ala His Asp Thr Leu 
            740                 745                 750         


Arg Leu Thr Cys Pro Pro Asp Tyr Thr Leu Thr Leu Arg Arg Ser Pro 
        755                 760                 765             


Asp Asp Ile Pro Leu Met Thr Pro Asn Thr Ile Thr Met Ile Pro Asn 
    770                 775                 780                 


Thr Leu Thr Gly Met Gln Pro Leu His Thr Phe Asn Thr Phe Ser Gly 
785                 790                 795                 800 


Gly Gln Asn Ser Thr Asn Leu Pro His Gly His Ser Thr Thr Arg Val 
                805                 810                 815     

<210>  3673
<211>  110
<212>  RNA
<213>  Homo sapiens


<220>  
<221>  misc_RNA
<223>  miRNA sequence.

<400>  3673
ggcuacaguc uuucuucaug ugacucgugg acuucccuuu gucauccuau gccugagaau     60

auaugaagga ggcugggaag gcaaagggac guucaauugu caucacuggc               110


<210>  3674
<211>  90
<212>  RNA
<213>  Homo sapiens


<220>  
<221>  misc_RNA
<223>  miRNA sequence.

<400>  3674
ucuaagaaac gcaguggucu cugaagccug caggggcagg ccagcccugc acugaacgcc     60

uguucuugcc agguggcaga agguugcugc                                      90


<210>  3675
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3675
tggcctggtc ratggtgatg a                                               21


<210>  3676
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3676
aggaaaactc rttctcccga a                                               21


<210>  3677
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3677
tgcactggtc rtagggcagg t                                               21


<210>  3678
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3678
gccacagcac rggtttgatg a                                               21


<210>  3679
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3679
gcccttttgg raggatcccc t                                               21


<210>  3680
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3680
aggatgaagt ygagggaccc a                                               21


<210>  3681
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3681
catctgtgac mcgggagaaa c                                               21


<210>  3682
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3682
tggggcgaga ygcggtacag a                                               21


<210>  3683
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3683
agaggcttca mgctacccct c                                               21


<210>  3684
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3684
aaaatgaaca yttccttttg t                                               21


<210>  3685
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3685
ttaaagcggt ytgtgttttt c                                               21


<210>  3686
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3686
cgattttgta rttgtctcct g                                               21


<210>  3687
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3687
aatgatacac rgctcatgaa t                                               21


<210>  3688
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3688
ggatcataaa ratgtattta g                                               21


<210>  3689
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3689
acttgagaag mttttggctt a                                               21


<210>  3690
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3690
tagcatatgc rctctgtatt c                                               21


<210>  3691
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3691
tttctgatga rgagtcagca a                                               21


<210>  3692
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3692
tgagattctc yggggtttat t                                               21


<210>  3693
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3693
ttctttggac rtttattttc t                                               21


<210>  3694
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3694
tcatagcaaa yagcagaggc a                                               21


<210>  3695
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3695
caggacatca kgcttgttgt c                                               21


<210>  3696
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3696
aagatcgaaa ygcaagtcat t                                               21


<210>  3697
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3697
caaggatttt mcattctttg g                                               21


<210>  3698
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3698
tccatctcct raataccata t                                               21


<210>  3699
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3699
tggttttctc ytcaccactc t                                               21


<210>  3700
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3700
atgagagatg ytggttttaa g                                               21


<210>  3701
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3701
ttaatttcaa ygtgttttct g                                               21


<210>  3702
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3702
ggtgacgtaa rgatattttg g                                               21


<210>  3703
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3703
gtattcattt racaaaattt a                                               21


<210>  3704
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3704
tgggagttag rgagatgagg g                                               21


<210>  3705
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3705
ttagaatagg ratgtggcaa g                                               21


<210>  3706
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3706
aaaataaggc rctgtttgcc c                                               21


<210>  3707
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3707
attgtagctg yttaataata a                                               21


<210>  3708
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3708
gaagaaaagc yctgtgagaa t                                               21


<210>  3709
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3709
tcctatagaa kcatactggc a                                               21


<210>  3710
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3710
tatcccattt kctcccagat c                                               21


<210>  3711
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3711
ccagttttca yagcttcact g                                               21


<210>  3712
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3712
tccttcactt ycacagctgt g                                               21


<210>  3713
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3713
tggtcttagc racttacttt a                                               21


<210>  3714
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3714
aagcttgtct rcctggcctc t                                               21


<210>  3715
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3715
atggaattca yagaaataaa g                                               21


<210>  3716
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3716
cagaagagaa magaagtaaa a                                               21


<210>  3717
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3717
atctgttaaa mccttaaatg a                                               21


<210>  3718
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3718
aatctcttac rggtcaatgt g                                               21


<210>  3719
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3719
gcatgccggg ytaaggaata t                                               21


<210>  3720
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3720
tgtcatcttg ygtcttttta g                                               21


<210>  3721
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3721
tttcttcttg yacccatatc c                                               21


<210>  3722
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3722
caacaagtga yttaacttac a                                               21


<210>  3723
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3723
ttggttttcc yggaattaat a                                               21


<210>  3724
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3724
taagtatctt kggttaaatt c                                               21


<210>  3725
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3725
ttggaagaac kgttctgtgg a                                               21


<210>  3726
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3726
gaaaaagaca ygatgcgtat t                                               21


<210>  3727
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3727
tttaaagctt ycttaataac a                                               21


<210>  3728
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3728
taaaggagtc ragaagtttg g                                               21


<210>  3729
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3729
tagagaacat ygaaagagga c                                               21


<210>  3730
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3730
tgaggtacca rataacatac c                                               21


<210>  3731
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3731
tgcttccttt rtagtaattc c                                               21


<210>  3732
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3732
ataatggatc rgtggagatt t                                               21


<210>  3733
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3733
gtattcacca mgcattttag g                                               21


<210>  3734
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3734
ttaaataagc rtagacttga g                                               21


<210>  3735
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3735
tcctgttcag ygatgtgccc c                                               21


<210>  3736
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3736
ggagggtact kgcaatagat g                                               21


<210>  3737
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3737
aaattttaca rtctcttagg a                                               21


<210>  3738
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3738
tagtatcccc rttttatgga t                                               21


<210>  3739
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3739
agaattagca yggcattgtg g                                               21


<210>  3740
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3740
accacagcat rccaccctcc t                                               21


<210>  3741
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3741
cttccttcag ytgccatgag a                                               21


<210>  3742
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3742
agacaaatag mcaagtcaag g                                               21


<210>  3743
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3743
taagtcccca kttaccacct a                                               21


<210>  3744
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3744
ggccatcctt yataaaacgg c                                               21


<210>  3745
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3745
tgcaccgtgc yatgtgggtt t                                               21


<210>  3746
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3746
tcagatcaca yagtgggaaa g                                               21


<210>  3747
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3747
gtttcaggga rggcacaaaa c                                               21


<210>  3748
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3748
aaatcacttc ytccacttag t                                               21


<210>  3749
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3749
tatcttttct matgctggaa a                                               21


<210>  3750
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3750
gggaatttcc rttcctttct t                                               21


<210>  3751
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3751
ccttaccccc maaaaaaaga a                                               21


<210>  3752
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3752
cagcagctac rtaaccatga t                                               21


<210>  3753
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3753
tacatgcgac ygcctggaga a                                               21


<210>  3754
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3754
agatttattc rtttttgatc c                                               21


<210>  3755
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3755
ataaacaggc ycactctgtt a                                               21


<210>  3756
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3756
aatccatcta rtagtctatt c                                               21


<210>  3757
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3757
ctgttgaaaa rgtgcacagc a                                               21


<210>  3758
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3758
aatttaaaaa ygcgtcttcg a                                               21


<210>  3759
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3759
cattgctaat ygatgggcat g                                               21


<210>  3760
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3760
taaaatgggt rtatcatctc t                                               21


<210>  3761
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3761
tgtaaagaag rgatgatcat g                                               21


<210>  3762
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3762
aaagaaatcc rttttacttt g                                               21


<210>  3763
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3763
tttgggttca raagaggatc c                                               21


<210>  3764
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3764
tcttaagttg ytaacagtta a                                               21


<210>  3765
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3765
acaaatcctc yggagcagca a                                               21


<210>  3766
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3766
gcctgaaaga ytgagggtct t                                               21


<210>  3767
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3767
tctgtgggca ygttgacaaa c                                               21


<210>  3768
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3768
ctggggatag rcttacttgt a                                               21


<210>  3769
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3769
aagtgtactg racagttaag g                                               21


<210>  3770
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3770
cctagctcac rgactcctaa a                                               21


<210>  3771
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3771
ttggggagga yttctaggag a                                               21


<210>  3772
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3772
atctctaacg ytatggtatt t                                               21


<210>  3773
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3773
ctcttcatca ytactatacc c                                               21


<210>  3774
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3774
acaaacaaac rcaatgccat c                                               21


<210>  3775
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3775
tgcttagttc ygcattatgc a                                               21


<210>  3776
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3776
tatttccaag rccaagaaac c                                               21


<210>  3777
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3777
ggcttcaggt rtctacagct t                                               21


<210>  3778
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3778
gtatttgctg ytgaaaaacc a                                               21


<210>  3779
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3779
tttcaaacta ygtactccct t                                               21


<210>  3780
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3780
acatgaatca kgtcactatt c                                               21


<210>  3781
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3781
gttagaatct ytgaagaata c                                               21


<210>  3782
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3782
catcttggct ygggaccaga g                                               21


<210>  3783
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3783
caagcctgac ktacctgcct t                                               21


<210>  3784
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3784
gttcctgata rtaaaactgc a                                               21


<210>  3785
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3785
cataagcacg rttcatcata t                                               21


<210>  3786
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3786
tttagttgtc mgttttctat a                                               21


<210>  3787
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3787
gattcttact rtgctatctg c                                               21


<210>  3788
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3788
ttctcaagtc ytagattctg a                                               21


<210>  3789
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3789
tcccaaggcc kcagctacac c                                               21


<210>  3790
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3790
tgtacggcca ygttttatat a                                               21


<210>  3791
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3791
tggagttcac ygttttttca t                                               21


<210>  3792
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3792
atgtcagcca yatttggtag t                                               21


<210>  3793
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3793
tctgtttcct raggagaaaa a                                               21


<210>  3794
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3794
tttttcttga rgtcatcatc t                                               21


<210>  3795
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3795
ctgcagttgg ygtttgaaac c                                               21


<210>  3796
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3796
atagttgtta ygctttaaat t                                               21


<210>  3797
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3797
taggtaccag kgttgctcac c                                               21


<210>  3798
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3798
tcaatcaatt rcaagccaag t                                               21


<210>  3799
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3799
agaatttata ygaaatttgc a                                               21


<210>  3800
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3800
agatcattcc raactgggta g                                               21


<210>  3801
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3801
tattgtttat ractatttta g                                               21


<210>  3802
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3802
gttctttgcc raattggcac t                                               21


<210>  3803
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3803
ttaagttttt ygaactttcc c                                               21


<210>  3804
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3804
ttcctgataa mccctggccc t                                               21


<210>  3805
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3805
tcttctgcct matttcttaa a                                               21


<210>  3806
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3806
tctttgcaat rgcagatgga a                                               21


<210>  3807
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3807
tgttctcttc ytccacagag g                                               21


<210>  3808
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3808
acaaaataac ygtagctttt g                                               21


<210>  3809
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3809
caaggcatcc rgcaatctaa a                                               21


<210>  3810
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3810
accgatagaa kagggaaagc a                                               21


<210>  3811
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3811
ccagtaaaac rtatctctgt a                                               21


<210>  3812
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3812
ataagtaagg yttcctgaaa t                                               21


<210>  3813
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3813
ccagtctata ygtcttagag g                                               21


<210>  3814
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3814
tagattgttt ygttgcaata t                                               21


<210>  3815
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3815
tctaccctaa rcatacatgg a                                               21


<210>  3816
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3816
ggaagcttta ygagttggtc t                                               21


<210>  3817
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3817
ggttaaattt ycatttaatt c                                               21


<210>  3818
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3818
ttttctcaac rcattacttc c                                               21


<210>  3819
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3819
gtttatgatc rtaagactaa a                                               21


<210>  3820
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3820
ctctgtcctc raggaaaagc a                                               21


<210>  3821
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3821
ttttaaatta kacagaacct t                                               21


<210>  3822
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3822
taatcctact rgaaataagc c                                               21


<210>  3823
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3823
aataagattg rgtgggagtg g                                               21


<210>  3824
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3824
gaatagtttt ygaattacta a                                               21


<210>  3825
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3825
atactcaacc rtcatatttc a                                               21


<210>  3826
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3826
caagaatacc rcagtatttt t                                               21


<210>  3827
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3827
tggaatagac rtttaatctc t                                               21


<210>  3828
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3828
attttgttgc yagctataaa a                                               21


<210>  3829
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3829
aacccttcca rgaaatctgg t                                               21


<210>  3830
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3830
aaatctgtgc ygggaatcaa g                                               21


<210>  3831
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3831
taaaggagct kagaagccac t                                               21


<210>  3832
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3832
gtttaatttg rtgtaatagg t                                               21


<210>  3833
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3833
acagagggcg rgagagggaa a                                               21


<210>  3834
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3834
acatgttcaa rgtcacatag c                                               21


<210>  3835
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3835
ttgacatgtg mcagtcactg t                                               21


<210>  3836
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3836
agaagtgtta mggaactggg t                                               21


<210>  3837
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3837
ggctcattct mgtggatatg g                                               21


<210>  3838
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3838
ccagattggg mgacaccagg t                                               21


<210>  3839
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3839
aacctcactc rtcattttct t                                               21


<210>  3840
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3840
tggacacaat mgtctggagc t                                               21


<210>  3841
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3841
aagcagacac maatgaagaa c                                               21


<210>  3842
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3842
aggtcgaact yccactttca g                                               21


<210>  3843
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3843
attacagtct yttctcattc a                                               21


<210>  3844
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3844
tctctgccag raaaattata a                                               21


<210>  3845
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3845
aggcttttgg ktggaaagaa g                                               21


<210>  3846
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3846
gaattcctat ycttttagcc t                                               21


<210>  3847
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3847
aattattgag rgttgttcat t                                               21


<210>  3848
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3848
actgaaacta raaagtgtac c                                               21


<210>  3849
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3849
gtagtgtatt ygttggaaga c                                               21


<210>  3850
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3850
ccatttgtgt rgagtttgta t                                               21


<210>  3851
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3851
cctaacatat rtattttttg a                                               21


<210>  3852
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3852
tgaggttagt mtggatgaat g                                               21


<210>  3853
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3853
tataatccct ytccatggca a                                               21


<210>  3854
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3854
ttttctcact ktacaaaaat g                                               21


<210>  3855
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3855
gtgtccctca ytgatcacaa a                                               21


<210>  3856
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3856
atggaacaca yaataagaca g                                               21


<210>  3857
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3857
agagtagaaa ktgtcttatt t                                               21


<210>  3858
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3858
tagagattat rttaaatctg t                                               21


<210>  3859
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3859
aagaatatta kaatgttagt c                                               21


<210>  3860
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3860
tgtagaacca rgtgttagct g                                               21


<210>  3861
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3861
tggattgact yaaactcttt t                                               21


<210>  3862
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3862
ctatgcaaaa rgtatcattg g                                               21


<210>  3863
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3863
tcctctaatt kagggactgc a                                               21


<210>  3864
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3864
tgcatgtact mttttgattt c                                               21


<210>  3865
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3865
gaggtagaca yggtaatgcc t                                               21


<210>  3866
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3866
tttaaaagtc ratatgaata t                                               21


<210>  3867
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3867
gatgtatagt rcaagagtaa g                                               21


<210>  3868
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3868
tcagggaaca yacctggaaa g                                               21


<210>  3869
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3869
ggttgggagt rggaggtagg a                                               21


<210>  3870
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3870
ctattagtgc mggattattg c                                               21


<210>  3871
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3871
gtttttctac mgctgtaaat g                                               21


<210>  3872
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3872
ttgcagtcat mggggcaggc a                                               21


<210>  3873
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3873
gaactatatg maataatggg a                                               21


<210>  3874
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3874
cctaaaagtg yagggatttg c                                               21


<210>  3875
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3875
ttcccaaaca yttttgatta g                                               21


<210>  3876
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3876
tgtggaactc yctgatttac t                                               21


<210>  3877
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3877
ctaagcacat ycaggtctat c                                               21


<210>  3878
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3878
agggtcagag raaatgttaa t                                               21


<210>  3879
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3879
tacaggagaa ygtagctaaa g                                               21


<210>  3880
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3880
tttcatgctg mgggctttga a                                               21


<210>  3881
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3881
ataacccgca magctttaaa a                                               21


<210>  3882
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3882
cagtcaaaaa ygagagacag a                                               21


<210>  3883
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3883
atagatgttg ycatgcctta g                                               21


<210>  3884
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3884
atattagaaa rtagatattt c                                               21


<210>  3885
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3885
aggagataca ygataggaga t                                               21


<210>  3886
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3886
gtcttggcca rccacagcaa c                                               21


<210>  3887
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3887
agacattatg ycacacccat a                                               21


<210>  3888
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3888
tcctagggca yatgagagtt t                                               21


<210>  3889
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3889
cccagctctg rgtttgaata t                                               21


<210>  3890
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3890
gggtaccaaa mgtttggtca a                                               21


<210>  3891
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3891
attattttgc rtatatattt t                                               21


<210>  3892
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3892
tatccatggg kagtatgttc t                                               21


<210>  3893
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3893
tagaccctac ragactactg g                                               21


<210>  3894
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3894
ctaggtccat rgttctcagt c                                               21


<210>  3895
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3895
tggttggatt rgtagacatc t                                               21


<210>  3896
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3896
agagactcag ragcctgtaa t                                               21


<210>  3897
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3897
acgtatgtag rttatgaatg g                                               21


<210>  3898
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3898
actttaacag rgacttcaaa g                                               21


<210>  3899
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3899
gggtgtggat rgggaggtgg a                                               21


<210>  3900
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3900
ttcatttcta rttcaacata g                                               21


<210>  3901
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3901
gtaataaagg kattaagtgg a                                               21


<210>  3902
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3902
aattcatact ytatcttcct t                                               21


<210>  3903
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3903
agtacctgcc yaataatgta t                                               21


<210>  3904
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3904
ttactatgtg ygagccacta t                                               21


<210>  3905
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3905
acgaaaaaac yaaagctgaa c                                               21


<210>  3906
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3906
caggactcaa rctacaagat g                                               21


<210>  3907
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3907
agggaggtac rtaggggcca g                                               21


<210>  3908
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3908
tagggatggt rtactcctca a                                               21


<210>  3909
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3909
gccccttata magcactcca g                                               21


<210>  3910
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3910
cctaacaatt rttccctctt t                                               21


<210>  3911
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3911
ttaagtaaat ygccctcgat c                                               21


<210>  3912
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3912
gcctggttgt raacaccaaa a                                               21


<210>  3913
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3913
aaggtgatca maagagtgat t                                               21


<210>  3914
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3914
ccactcttca ytcatatacc t                                               21


<210>  3915
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3915
tacttctctc rgttatggct g                                               21


<210>  3916
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3916
aatctttgtt yaaattgacc t                                               21


<210>  3917
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3917
gttattgagg yctgtataac a                                               21


<210>  3918
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3918
aataacaaga rgagcctcag a                                               21


<210>  3919
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3919
aaaattccta ygggtctttg a                                               21


<210>  3920
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3920
tcaaccttca rcataattgt c                                               21


<210>  3921
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3921
tggcatgatg raaatggtta a                                               21


<210>  3922
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3922
aagcacacaa ytgagagaat a                                               21


<210>  3923
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3923
aaggaagtat ycgaaggtga t                                               21


<210>  3924
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3924
ctatggtgaa rtccttgtta t                                               21


<210>  3925
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3925
ccctatgaaa ytgatcactt c                                               21


<210>  3926
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3926
ctttgccacc kcttctgcag t                                               21


<210>  3927
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3927
ctactcctgc rtcctttctg c                                               21


<210>  3928
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3928
ctgtggtcat rgtgttttat g                                               21


<210>  3929
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3929
cattacatca mactcttagc t                                               21


<210>  3930
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3930
gcatacatga rtgaacatag a                                               21


<210>  3931
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3931
acatggggtt ycctgatatt g                                               21


<210>  3932
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3932
tacttggcac magaaagtgg a                                               21


<210>  3933
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3933
ttcttgtacc ragcaagcat c                                               21


<210>  3934
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3934
ttacactgtt yttttttctt t                                               21


<210>  3935
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3935
tcttatcatt kttctatatc g                                               21


<210>  3936
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3936
tagagataga matgaagtgg a                                               21


<210>  3937
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3937
ccaactagac ygaatccctg a                                               21


<210>  3938
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3938
cctagcagca rggcttctgt g                                               21


<210>  3939
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3939
tatgatggat rcacaaggaa t                                               21


<210>  3940
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3940
aggctgaaag ygggaggccc a                                               21


<210>  3941
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3941
cctatgattc katctttact a                                               21


<210>  3942
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3942
ggctgtgaga rtcatagctc a                                               21


<210>  3943
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3943
tggtaaagga raagcatgat t                                               21


<210>  3944
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3944
taaaatttta rtaggtagga t                                               21


<210>  3945
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3945
ttatgtggaa yggttcaagt a                                               21


<210>  3946
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3946
ctgccccaca ragtttcata g                                               21


<210>  3947
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3947
gagctgctaa ygataagcag a                                               21


<210>  3948
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3948
tggggctctt yagccctcaa t                                               21


<210>  3949
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3949
ttttcctgtc rttaacatct g                                               21


<210>  3950
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3950
tatccctgcc ytcttctggc c                                               21


<210>  3951
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3951
tggcttggca rggagagtcg g                                               21


<210>  3952
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3952
ctggattata yttgtctata t                                               21


<210>  3953
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3953
ctaccgctgc rtggcatgga a                                               21


<210>  3954
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3954
ttctgtgttg ytggaccaca g                                               21


<210>  3955
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3955
ttttggtgct yccttactgc t                                               21


<210>  3956
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3956
ataaggcaac ygtctagagg a                                               21


<210>  3957
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3957
ataactaaag yaccaacctg g                                               21


<210>  3958
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3958
gcaggaaaac rtttatctct g                                               21


<210>  3959
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3959
cctgttgaca ygtgccctta a                                               21


<210>  3960
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3960
aaatgtgcca racaatcatt t                                               21


<210>  3961
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3961
agttctgtga rgctgtacct a                                               21


<210>  3962
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3962
agtagacaac yggaaacaaa g                                               21


<210>  3963
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3963
ccccaggcca ycgtcctggg g                                               21


<210>  3964
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3964
acctggagct rgagttcccc t                                               21


<210>  3965
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3965
ctctgaggac ycctgccatc c                                               21


<210>  3966
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3966
ccagtctgtt ktgttacttg a                                               21


<210>  3967
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3967
gttcctcttc rtatatcatg c                                               21


<210>  3968
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3968
ctacaagcag ktcttacttg g                                               21


<210>  3969
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3969
atatctccaa yaaaggtaag c                                               21


<210>  3970
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3970
acatgctcca rgcataatca a                                               21


<210>  3971
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3971
attttactaa ygtatcaaag a                                               21


<210>  3972
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3972
tagactataa ytggtagttt c                                               21


<210>  3973
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3973
acttttctgt ytctttctgt c                                               21


<210>  3974
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3974
ttggtcccaa rtcagacgaa g                                               21


<210>  3975
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3975
cagagtgaag rgtttcagaa g                                               21


<210>  3976
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3976
gacaagtatt mtctgcttct g                                               21


<210>  3977
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3977
agtttgtggc rgcctggccg g                                               21


<210>  3978
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3978
cttccaaaac mtggtccatt t                                               21


<210>  3979
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3979
cccacatggg raatttctct t                                               21


<210>  3980
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3980
gcctttgata maagccgttt a                                               21


<210>  3981
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3981
gaataacacc ygaatgcaaa t                                               21


<210>  3982
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3982
tgttattatt rttaacgttt t                                               21


<210>  3983
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3983
tcttaggtga ytgaatacag t                                               21


<210>  3984
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3984
gattagagaa ygtgcccaag a                                               21


<210>  3985
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3985
ttaagtttta ytttttccag a                                               21


<210>  3986
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3986
ccaaatctta yatggttctt g                                               21


<210>  3987
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3987
aataaagctg matcagtgct a                                               21


<210>  3988
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3988
ttgatactag rcctttacat c                                               21


<210>  3989
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3989
tcttcctacc yttttattat t                                               21


<210>  3990
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3990
agaaaatgcc yaggtccaga t                                               21


<210>  3991
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3991
gagcttgcca raccaaaacc a                                               21


<210>  3992
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3992
acttcttgct mttcccgtat g                                               21


<210>  3993
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3993
acataatctt rggacaagcc c                                               21


<210>  3994
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3994
tctgttgtat ytacttagat g                                               21


<210>  3995
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3995
aggagatcta yaggggctga g                                               21


<210>  3996
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3996
tgaaagatta raagggaagc t                                               21


<210>  3997
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3997
agtaaggtat kaaatagagt g                                               21


<210>  3998
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3998
agaaagaaat yacctctaac a                                               21


<210>  3999
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  3999
gtagttgaac yaaattaatc a                                               21


<210>  4000
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4000
ctctttggcc rtccattctg g                                               21


<210>  4001
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4001
ccctccctga ygccgaagca g                                               21


<210>  4002
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4002
ggtcaattct yaaaggaaat g                                               21


<210>  4003
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4003
atttccaagt ytgcagaaaa g                                               21


<210>  4004
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4004
cgtgactgtg yttttgaaga t                                               21


<210>  4005
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4005
cttaaagggg ytagagtgaa c                                               21


<210>  4006
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4006
cagctggaca ygatcatctg a                                               21


<210>  4007
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4007
tgagggaaac rttattaaaa t                                               21


<210>  4008
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4008
aaggagattt rgaagagact t                                               21


<210>  4009
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4009
tgttgtgtct ycctaatgat t                                               21


<210>  4010
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4010
ggcctcttca rttctaagtt t                                               21


<210>  4011
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4011
ggctatgcac rtcactgagg t                                               21


<210>  4012
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4012
ctttcaacat ytgggatgct g                                               21


<210>  4013
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4013
atccatagca yttcctttat a                                               21


<210>  4014
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4014
catctctgta ygcagccctt t                                               21


<210>  4015
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4015
cccacccaga ygcaaattta c                                               21


<210>  4016
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4016
atattacacc rggtggaaca g                                               21


<210>  4017
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4017
gagacggaaa kgagactttt c                                               21


<210>  4018
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4018
aacatggcac yaatgtttct t                                               21


<210>  4019
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4019
aaaagatagg ygccaccaaa c                                               21


<210>  4020
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4020
tgcgtttctt ytggtctcag g                                               21


<210>  4021
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4021
ttgaacctca kttgggtctt c                                               21


<210>  4022
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4022
aggcaaaacc raactatagt a                                               21


<210>  4023
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4023
ttgcttagac matgcctagt c                                               21


<210>  4024
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4024
tgcatgaacc ytcccttatg a                                               21


<210>  4025
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4025
ataaaaatcc rttatgtacc a                                               21


<210>  4026
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4026
tcatgtgcct rcatgaaggt g                                               21


<210>  4027
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4027
cctccaaaac ygagctggca a                                               21


<210>  4028
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4028
tttggcacca rtgctttgtg a                                               21


<210>  4029
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4029
agctcctaat kgtcaccacc t                                               21


<210>  4030
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4030
gaatcccttt ygtcatatgc t                                               21


<210>  4031
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4031
cacaagcctc ratttcctta t                                               21


<210>  4032
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4032
aggagtttaa rtaatttgcc t                                               21


<210>  4033
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4033
agcaggcata ygaaagagtg t                                               21


<210>  4034
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4034
ttctcttccc rtctcctcac c                                               21


<210>  4035
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4035
cagggcttgg raagggaaga g                                               21


<210>  4036
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4036
catttcaaat yaagcaaggt g                                               21


<210>  4037
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4037
tttatgcccc rgggaccaaa g                                               21


<210>  4038
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4038
tcctggggca ktttgttggg c                                               21


<210>  4039
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4039
cccggggtcc ycttggaaaa t                                               21


<210>  4040
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4040
acacacacct yttccttgag c                                               21


<210>  4041
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4041
aggttgaaat yaggctgagt g                                               21


<210>  4042
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4042
ttggaagaag yagcttcctg t                                               21


<210>  4043
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4043
accagtgggc raactattct a                                               21


<210>  4044
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4044
aattgctcca yatccttgct a                                               21


<210>  4045
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4045
aggcaggagt rtatataaat a                                               21


<210>  4046
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4046
tcaaaattaa rgtaatctct g                                               21


<210>  4047
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4047
taatgttttg rtaaagaaaa a                                               21


<210>  4048
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4048
tgcatgtttt ycccaccata c                                               21


<210>  4049
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4049
ttattcagct yggctgccat a                                               21


<210>  4050
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4050
aaacaattat yctccatgaa g                                               21


<210>  4051
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4051
ttaaatggga yatcaaagca a                                               21


<210>  4052
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4052
tttttattaa ygattcaaac t                                               21


<210>  4053
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4053
gttgattttg ktttttgtta a                                               21


<210>  4054
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4054
tgaagtgagg rgacccaaag a                                               21


<210>  4055
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4055
aaggtctctg kggggaatat t                                               21


<210>  4056
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4056
tgataaatga yggcctttta a                                               21


<210>  4057
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4057
gagctacact ktctttggta a                                               21


<210>  4058
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4058
acttaaaatc ragggtgtat t                                               21


<210>  4059
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4059
agctataaag raaaaaaata a                                               21


<210>  4060
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4060
ttcaagtaac ygttaacagt g                                               21


<210>  4061
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4061
tcctccaatc raggagactg t                                               21


<210>  4062
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4062
tacagaactc rtctaggaaa a                                               21


<210>  4063
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4063
gccattttat ytgggtagtt a                                               21


<210>  4064
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4064
ttcatgaaca ytcttattta t                                               21


<210>  4065
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4065
gtgaacatac rcacacatgt g                                               21


<210>  4066
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4066
gtcatgagtc rtgtgtagta a                                               21


<210>  4067
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4067
aactacaata mcccaggttt c                                               21


<210>  4068
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4068
ggtgatcata ygcaaataac t                                               21


<210>  4069
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4069
agtcaggtga ygcagggttt t                                               21


<210>  4070
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4070
catttcctgc ycttaacagg c                                               21


<210>  4071
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4071
gctaagcttt rcgggacagt g                                               21


<210>  4072
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4072
agaagcatat rttgagggac t                                               21


<210>  4073
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4073
gagagtaaag ytgactaaca t                                               21


<210>  4074
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4074
aagcttcagc rcaaaacatt t                                               21


<210>  4075
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4075
ttccatacag yactgagagg g                                               21


<210>  4076
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4076
gaaggcagca rcagagagca t                                               21


<210>  4077
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4077
tggcttgttg maacattaca a                                               21


<210>  4078
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4078
aagggcagca ragtgaagtg c                                               21


<210>  4079
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4079
attgggaaag rgcaggagaa a                                               21


<210>  4080
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4080
gggatgctgg ygggttagca c                                               21


<210>  4081
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4081
ttttttgttt mtcctccttg a                                               21


<210>  4082
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4082
aactgatggg ycgagcctgc t                                               21


<210>  4083
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4083
tgccagtcta rcctactttg g                                               21


<210>  4084
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4084
ataagcactc rtttctgctg g                                               21


<210>  4085
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4085
actaaggacg rctagactga t                                               21


<210>  4086
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4086
actttgcttc yaattacagc t                                               21


<210>  4087
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4087
ctagatttac rtagttcggc t                                               21


<210>  4088
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4088
tattaattaa ragagaaatc t                                               21


<210>  4089
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4089
catgaagacc ygactgagct t                                               21


<210>  4090
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4090
ttgaagccca rggaattcca t                                               21


<210>  4091
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4091
tggaactaaa ycattctgta a                                               21


<210>  4092
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4092
tccctaacca ygtggggctc c                                               21


<210>  4093
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4093
tagtgaatgt rtgttcagca a                                               21


<210>  4094
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4094
tgtcaggata yctaatgggt g                                               21


<210>  4095
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4095
tgaaaaggat rggggaagga g                                               21


<210>  4096
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4096
gtgacttcag yggttctatc t                                               21


<210>  4097
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4097
tgccctacca rtattactgt t                                               21


<210>  4098
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4098
atgactgaag ytcctaaagt t                                               21


<210>  4099
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4099
ttagactgag rgtgagggag t                                               21


<210>  4100
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4100
acttacttga ygattttgat g                                               21


<210>  4101
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4101
ggaaggtagg rtatatggga t                                               21


<210>  4102
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4102
tttctaatta ragggacctg g                                               21


<210>  4103
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4103
ccagctatcc rtgtgcttgc t                                               21


<210>  4104
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4104
gttttattcc ratttgattt g                                               21


<210>  4105
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4105
gctaacttca raaggaagag g                                               21


<210>  4106
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4106
ctttttggga mgaacagctt a                                               21


<210>  4107
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4107
ctttatatca ytacttggac a                                               21


<210>  4108
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4108
tgcacggtta yacattttta a                                               21


<210>  4109
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4109
taaggcaaga yaatgtagac a                                               21


<210>  4110
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4110
ctcagtgtac yctgattttg t                                               21


<210>  4111
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4111
agcctacctt kctttggttg a                                               21


<210>  4112
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4112
cattcaacaa rtttcaaacc c                                               21


<210>  4113
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4113
gccaagaacc rtcccagatg t                                               21


<210>  4114
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4114
gcttacacgg yacacagtcc a                                               21


<210>  4115
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4115
acgggaacat ygtctgtgta c                                               21


<210>  4116
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4116
gcccatgcac yggggtgact g                                               21


<210>  4117
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4117
atcagtaaaa racatgggat c                                               21


<210>  4118
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4118
actcacattt rtgagttttc a                                               21


<210>  4119
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4119
tgctcatcac rttcatccac t                                               21


<210>  4120
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4120
cagatgggaa ytcacatgga g                                               21


<210>  4121
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4121
ttatgaggca yattatgttc t                                               21


<210>  4122
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4122
atattactag ktcttatgtc t                                               21


<210>  4123
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4123
aacaataaca ygtgagtcta a                                               21


<210>  4124
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4124
cacacataat rgacacatcc c                                               21


<210>  4125
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4125
aggctggagg mgttggtgct g                                               21


<210>  4126
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4126
ttatttttga yttgaccacc a                                               21


<210>  4127
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4127
ctggtctccc rtacctctga c                                               21


<210>  4128
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4128
cttggagatg rtagggtgca g                                               21


<210>  4129
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4129
ccccctcaca mtcttactac c                                               21


<210>  4130
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4130
tcagatgtcc raaaggttct c                                               21


<210>  4131
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4131
accttttttt yccccctctg g                                               21


<210>  4132
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4132
accatctgcc raacttgcac t                                               21


<210>  4133
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4133
attttctgca ytagaataga t                                               21


<210>  4134
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4134
gggatttaga rtgttagagg t                                               21


<210>  4135
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4135
ttgtctccgt ytgtccacaa a                                               21


<210>  4136
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4136
gaaaagtttt raaacactag g                                               21


<210>  4137
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4137
ttgtaatgtc kaaaaggaat t                                               21


<210>  4138
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4138
aaagaataaa rgaaggcaca g                                               21


<210>  4139
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4139
tgtgagtgtt ragcactgtt c                                               21


<210>  4140
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4140
gaagaatcct rtctagtaga c                                               21


<210>  4141
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4141
gctagggaaa raagtggaca a                                               21


<210>  4142
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4142
tgagaaggtc rctatcaatg a                                               21


<210>  4143
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4143
ttcctccctg rattccaggg c                                               21


<210>  4144
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4144
tagcaagagt rgggccacga g                                               21


<210>  4145
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4145
tacacttcac rtctgtgctg c                                               21


<210>  4146
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4146
ggctcctagg rctcctaggg c                                               21


<210>  4147
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4147
caatgcccct rattaaacta a                                               21


<210>  4148
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4148
attctacctc rtgtaggaag t                                               21


<210>  4149
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4149
ctgtaattgg kaaatacaca t                                               21


<210>  4150
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4150
ccatttgggc rgctataaca a                                               21


<210>  4151
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4151
ggaccagatg mcccagtaac g                                               21


<210>  4152
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4152
ctgcctccaa ytactcagga a                                               21


<210>  4153
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4153
actctttcct rggggtaatt g                                               21


<210>  4154
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4154
tttgcataat rtttatcaca g                                               21


<210>  4155
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4155
cccttctagc rtctctggtg a                                               21


<210>  4156
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4156
tcttccactt ytggtggtgg t                                               21


<210>  4157
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4157
attaagtaaa rtaagtcagt c                                               21


<210>  4158
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4158
gtcctaaaga rcagaccatt g                                               21


<210>  4159
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4159
atgggtgtcc ytgctaagaa g                                               21


<210>  4160
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4160
gccctgctcc ratcattgac c                                               21


<210>  4161
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4161
aaagagccct rtagaacaat c                                               21


<210>  4162
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4162
tatgtggcca mgacttactg g                                               21


<210>  4163
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4163
gaaaggcaag maccaccaaa t                                               21


<210>  4164
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4164
tttcctacct ktttcctctg t                                               21


<210>  4165
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4165
cactaggcac rttcatctct c                                               21


<210>  4166
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4166
caagggtatc rtatgcgtct a                                               21


<210>  4167
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4167
agacggaagt yagagatttt t                                               21


<210>  4168
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4168
ggttctcaag raaggaaaag g                                               21


<210>  4169
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4169
aagtgtgcta yatttcacaa a                                               21


<210>  4170
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4170
agcactccct yattaccttg g                                               21


<210>  4171
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4171
tatatattag rtagatgtgt a                                               21


<210>  4172
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4172
tccccttcat yggcaacaca c                                               21


<210>  4173
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4173
tataggacac ragagttgtc c                                               21


<210>  4174
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4174
ctcaataccg mccccagtgt a                                               21


<210>  4175
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4175
tgacatagct rggcttcagg g                                               21


<210>  4176
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4176
ctatggcatg rcaccatttt a                                               21


<210>  4177
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4177
aagaaaggat kgttcaactt g                                               21


<210>  4178
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4178
aagattttat kgacaaagcc c                                               21


<210>  4179
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4179
accttcaatc rttatgttgc t                                               21


<210>  4180
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4180
ttaggagtcc ratagccttt c                                               21


<210>  4181
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4181
attccaataa rccagggtta t                                               21


<210>  4182
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4182
ctacggattg rataaagaaa a                                               21


<210>  4183
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4183
cttcgtgtac kccctccttc g                                               21


<210>  4184
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4184
ttccaactgt rcttccaacc a                                               21


<210>  4185
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4185
gttgccatcc rtctacatgc a                                               21


<210>  4186
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4186
tcgattctca yagggaatga g                                               21


<210>  4187
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4187
agttggtgta rgagcttggg g                                               21


<210>  4188
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4188
ctgtgggcaa rtgttcctag t                                               21


<210>  4189
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4189
aatgatgacc rgaaagaaag g                                               21


<210>  4190
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4190
atattaagag yaagtgttta t                                               21


<210>  4191
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4191
gaatgcataa ygagccctgt g                                               21


<210>  4192
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4192
ttcagactgc rcgtactgtg g                                               21


<210>  4193
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4193
actacaatga yatttttcct c                                               21


<210>  4194
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4194
tcttccacac rtcctcttct t                                               21


<210>  4195
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4195
accaatccct rctgcttaat c                                               21


<210>  4196
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4196
ggaaacagaa ytagaagaag t                                               21


<210>  4197
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4197
taaccttttc rtagcccaca a                                               21


<210>  4198
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4198
tagtctaggt rtggaatttc a                                               21


<210>  4199
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4199
tttttaggtt rgaaagatac t                                               21


<210>  4200
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4200
aagtacatac rcactggttg g                                               21


<210>  4201
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4201
atttattcat kctttcttct c                                               21


<210>  4202
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4202
agggcaagaa rgtatggaaa g                                               21


<210>  4203
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4203
atttgaattg ytttatccaa a                                               21


<210>  4204
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4204
acttgataat rtatgacagg a                                               21


<210>  4205
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4205
acacccatag racctctttt a                                               21


<210>  4206
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4206
ttctagttaa rtctgtctct c                                               21


<210>  4207
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4207
agtcatatat rcttggattt c                                               21


<210>  4208
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4208
aatgaaaagt ytctatcaaa g                                               21


<210>  4209
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4209
gaaaaggtta rcatctatta c                                               21


<210>  4210
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4210
gccaagcgag ratggagttt t                                               21


<210>  4211
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4211
gtccaacctc yggaaaagaa a                                               21


<210>  4212
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4212
caaaatgctc rctaaacaag c                                               21


<210>  4213
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4213
aattagagac kggttgtttc a                                               21


<210>  4214
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4214
tctgatattt rttttcagac a                                               21


<210>  4215
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4215
ttttctggtt ytgtttctga t                                               21


<210>  4216
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4216
gcccgtgtat yggtgtgggt a                                               21


<210>  4217
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4217
tacatatgca ygcgtagtgt t                                               21


<210>  4218
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4218
cactataaga ytggaagtca g                                               21


<210>  4219
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4219
acacaaactg rtaaaaacgt a                                               21


<210>  4220
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4220
caagaatttt magatgggtt c                                               21


<210>  4221
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4221
tttcaaggcc rtggctcttc c                                               21


<210>  4222
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4222
aattttatca yagtgaattt c                                               21


<210>  4223
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4223
tttttgaagc kcaagacaga a                                               21


<210>  4224
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4224
aattcttgat yactgtgaga g                                               21


<210>  4225
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4225
gggtatatct rcagaagcca g                                               21


<210>  4226
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4226
tcttcttggc kctgtgtgta c                                               21


<210>  4227
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4227
gtccaagctg ytggaaaaag c                                               21


<210>  4228
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4228
ctttaatgac rctttgttag g                                               21


<210>  4229
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4229
catctaggtc rcctgacaga g                                               21


<210>  4230
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4230
cttttaaata ygtaagataa t                                               21


<210>  4231
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4231
aaaagcagcc rtttcatatt a                                               21


<210>  4232
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4232
atcaatattt yagaattcca t                                               21


<210>  4233
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4233
gagaaaaggc rctaggagat a                                               21


<210>  4234
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4234
cccaatgtga yagtgttaga a                                               21


<210>  4235
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4235
gactctcagt rtgtgttagg g                                               21


<210>  4236
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4236
tgttctattt yagatattca g                                               21


<210>  4237
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4237
tgtccccata ktattgctat t                                               21


<210>  4238
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4238
gcttgaagtt raatagcatt a                                               21


<210>  4239
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4239
tagcaagcat mtataatgtg c                                               21


<210>  4240
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4240
tcaagaggct rtaactgagg a                                               21


<210>  4241
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4241
gcaagggcca ygacgtaggc a                                               21


<210>  4242
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4242
tttccttcct ragctttcag g                                               21


<210>  4243
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4243
ccctgccctc rtaagggttt a                                               21


<210>  4244
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4244
ttctttagtt ygacacatat t                                               21


<210>  4245
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4245
cagaagtgga ygtcaacatg t                                               21


<210>  4246
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4246
aataagggga yaatgcttcc c                                               21


<210>  4247
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4247
ggagaacctg yaactaacac a                                               21


<210>  4248
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4248
catggcagtg rgtaagcgta t                                               21


<210>  4249
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4249
tgcatgtaca rtttatataa g                                               21


<210>  4250
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4250
ccaagcctcc rttttctctt c                                               21


<210>  4251
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4251
aaatcagtgc yaactgtgcc a                                               21


<210>  4252
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4252
ttatctacat ytgctagact g                                               21


<210>  4253
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4253
gtaaatgacc yaattggagg a                                               21


<210>  4254
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4254
taaattggtg ygaggaaatg t                                               21


<210>  4255
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4255
ttcaggggta ycaatgtaac a                                               21


<210>  4256
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4256
ccatcttaat rttatttcaa t                                               21


<210>  4257
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4257
ctgtgctcaa yatttcctca a                                               21


<210>  4258
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4258
ctctgatata ytgctgaggg t                                               21


<210>  4259
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4259
atgaggtcaa mtttcaaatt t                                               21


<210>  4260
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4260
gcagaaatgt maaatggtat a                                               21


<210>  4261
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4261
gtgaattatc rtcattcaac a                                               21


<210>  4262
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4262
aaaaatgaac rtggcctctc t                                               21


<210>  4263
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4263
acgggcagaa kggagttctc c                                               21


<210>  4264
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4264
aaatatccaa rccatgtaat g                                               21


<210>  4265
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4265
actgtgttcc yggaccttac c                                               21


<210>  4266
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4266
taaatttgag kgttaacggt c                                               21


<210>  4267
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4267
tggagaaaag rctagtggaa c                                               21


<210>  4268
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4268
gccacagaac rgtatgcaac a                                               21


<210>  4269
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4269
tggaagaaac yaatccaggc c                                               21


<210>  4270
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4270
tggttggaat ktaatcactt t                                               21


<210>  4271
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4271
catgtgcagg ygagggcatg a                                               21


<210>  4272
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4272
ctgtggttgc yagatccagt c                                               21


<210>  4273
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4273
ggaactcttc yccaaggagt c                                               21


<210>  4274
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4274
aacatctaac rtgagcaacc a                                               21


<210>  4275
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4275
ccttgcacat mgcagatact c                                               21


<210>  4276
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4276
aaaatcccat rtttggtctc g                                               21


<210>  4277
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4277
tatgttatct yagtccaaaa a                                               21


<210>  4278
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4278
tgttaggcat yaaattctat a                                               21


<210>  4279
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4279
tgaatttgga rttcccggta c                                               21


<210>  4280
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4280
agttaccaca maagccctaa a                                               21


<210>  4281
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4281
acccatctgg yccaaggggt c                                               21


<210>  4282
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4282
ctacagccac ytctctgggc a                                               21


<210>  4283
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4283
ggagaaacta yaaatgaaag t                                               21


<210>  4284
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4284
atttatcaca mgaaggtttg a                                               21


<210>  4285
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4285
tccataagtc kgctctggga a                                               21


<210>  4286
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4286
ctcccctcac ycctagctgt c                                               21


<210>  4287
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4287
tattcaaagg raattaagtg c                                               21


<210>  4288
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4288
tggatcatgc ytttggtgta g                                               21


<210>  4289
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4289
atgagtgaaa ycatagagga t                                               21


<210>  4290
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4290
tttgtaacat rttgcttgga g                                               21


<210>  4291
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4291
aaatcctgac rttcatgagc t                                               21


<210>  4292
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4292
ttattttaga katgtgtaca g                                               21


<210>  4293
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4293
agactgaagc yaagagcacc t                                               21


<210>  4294
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4294
ttcaaggaca rtgctttatt a                                               21


<210>  4295
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4295
agcaactatt kcccttctgc a                                               21


<210>  4296
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4296
gatattagat rtaaaagaaa g                                               21


<210>  4297
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4297
aaagtgaaat rtggatgcta a                                               21


<210>  4298
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4298
ctaaatatct rtctaatgac c                                               21


<210>  4299
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4299
gagaagctta ygccatacaa t                                               21


<210>  4300
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4300
ttatttatat ktctacttaa t                                               21


<210>  4301
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4301
caaaaagttt mcaagcttag a                                               21


<210>  4302
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4302
ttttgaaaca rggtagagta a                                               21


<210>  4303
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4303
tcttaaaaat rtaagttgac a                                               21


<210>  4304
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4304
aaaataatga yagatgacaa g                                               21


<210>  4305
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4305
actggactat kcgacagaac a                                               21


<210>  4306
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4306
taaatatttt ycccaagcaa t                                               21


<210>  4307
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4307
caaaaccaag yccccacaaa g                                               21


<210>  4308
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4308
aaaaatccct mtccagtgac a                                               21


<210>  4309
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4309
ataacaatcc ycagtgcaca t                                               21


<210>  4310
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4310
ttattatact rtgcctaaca t                                               21


<210>  4311
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4311
taggtcctac ygaatgaaaa g                                               21


<210>  4312
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4312
atgaaagaag ycaatataag a                                               21


<210>  4313
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4313
agcagagtgg rgaaattttg a                                               21


<210>  4314
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4314
atctgattat ygacaaacct c                                               21


<210>  4315
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4315
tcactatgtt kggtattgct t                                               21


<210>  4316
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4316
cataacaata rtgcttttgc t                                               21


<210>  4317
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4317
gatatagtct ycagtgtctt t                                               21


<210>  4318
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4318
aaagtctttc rgagttgaac t                                               21


<210>  4319
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4319
gtcggaccat ygattacccc c                                               21


<210>  4320
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4320
ctgaaataaa yaaggcttcc a                                               21


<210>  4321
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4321
gtctaggctt yataaatcaa a                                               21


<210>  4322
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4322
ttcaagagct rggggccctg g                                               21


<210>  4323
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4323
gtggaattta raagtattgt a                                               21


<210>  4324
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4324
ttttggactt yatcttttgt t                                               21


<210>  4325
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4325
agaaggcatt mcacatatgt t                                               21


<210>  4326
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4326
ctggaaaatt mtttgttgtc a                                               21


<210>  4327
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4327
tggagaactc rttattaaat t                                               21


<210>  4328
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4328
gcttttcctg ytcttctata c                                               21


<210>  4329
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4329
ctattgtgtc yggaattggt g                                               21


<210>  4330
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4330
taagctcaaa yaggtttgat t                                               21


<210>  4331
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4331
tattcctggc rggctcctct g                                               21


<210>  4332
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4332
tttattgaac yataacacaa c                                               21


<210>  4333
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4333
tcactgactt yctgtgttat t                                               21


<210>  4334
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4334
cttctaacac ygtgaagcca a                                               21


<210>  4335
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4335
agtttggcag ygtggaactt c                                               21


<210>  4336
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4336
tatcaaaact rtatcaattt c                                               21


<210>  4337
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4337
acacaagtcc matcccattt c                                               21


<210>  4338
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4338
agccattctg ytcaaaaagt t                                               21


<210>  4339
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4339
aaggcacaaa rgctattcaa t                                               21


<210>  4340
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4340
gcatgtattt ktcaagattc g                                               21


<210>  4341
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4341
tctcagaatc rggacagaaa g                                               21


<210>  4342
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4342
tatcattatc mataaaaaat t                                               21


<210>  4343
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4343
ctgtgtgtta ytgagtgtta a                                               21


<210>  4344
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4344
aacacatctg rcaaatatta a                                               21


<210>  4345
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4345
caccatcact mtccatggaa a                                               21


<210>  4346
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4346
tcaatcaatc ytctgcaagt a                                               21


<210>  4347
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4347
cagtggaagt rtcagctctt a                                               21


<210>  4348
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4348
gagagcagag rtggtcaccc t                                               21


<210>  4349
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4349
aactagttgc yggatacttg c                                               21


<210>  4350
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4350
gctcagacag yggccccacc a                                               21


<210>  4351
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4351
acctggggga ytttagggtc c                                               21


<210>  4352
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4352
tgcaaagtta yttaatcttt g                                               21


<210>  4353
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4353
aatcatcatc rtgctgctag a                                               21


<210>  4354
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4354
agctttttac maaaagtggc c                                               21


<210>  4355
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4355
cttgtcaact ygtcaatatt t                                               21


<210>  4356
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4356
agttgttggg yttctgttct t                                               21


<210>  4357
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4357
attccttctg ragaactttt a                                               21


<210>  4358
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4358
atggatagag ygtgggtcag c                                               21


<210>  4359
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4359
cgcacacatg ygctcagagg t                                               21


<210>  4360
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4360
ggcctaaaat yccacagttg a                                               21


<210>  4361
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4361
gcctgtctcc magctgccta g                                               21


<210>  4362
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4362
gctccactta yagcaagcct t                                               21


<210>  4363
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4363
ttttttcccc ygaatgctga t                                               21


<210>  4364
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4364
tccaaaatct rtaaaatgtg g                                               21


<210>  4365
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4365
ggtagataga kagtagcaca c                                               21


<210>  4366
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4366
cttgaaaatt rgtctgctgc t                                               21


<210>  4367
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4367
gttatatagc yaaaggaaat a                                               21


<210>  4368
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4368
gtcttgaatt kcagaggaaa a                                               21


<210>  4369
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4369
tgatacaaag yggtcatctt a                                               21


<210>  4370
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4370
gaaaaaaagg ycttatgatg g                                               21


<210>  4371
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4371
ttctcaatag rtaagagcag c                                               21


<210>  4372
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4372
aatgcaaagg kggcaaggat c                                               21


<210>  4373
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4373
agcaaaaata yactcaaata t                                               21


<210>  4374
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4374
gagacgtagc rtacccacct t                                               21


<210>  4375
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4375
ttgatacatt ygtcaaaaca g                                               21


<210>  4376
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4376
cactactgtt ygaattaagt a                                               21


<210>  4377
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4377
atttgagcta ytgatcctgt t                                               21


<210>  4378
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4378
ttattgtaag ytgtttagaa a                                               21


<210>  4379
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4379
tacttggtca rcccacagat t                                               21


<210>  4380
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4380
gtaatttaaa ratagaatag t                                               21


<210>  4381
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4381
agtcctggct rtaacttagg t                                               21


<210>  4382
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4382
agtaatcatt ygctcagtcc a                                               21


<210>  4383
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4383
attcattcaa ytatttaaca a                                               21


<210>  4384
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4384
aattatcctg mcaaaaatat a                                               21


<210>  4385
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4385
tagcttatga yggatgatac a                                               21


<210>  4386
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4386
caattttgcc raagttacta a                                               21


<210>  4387
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4387
gtcacttagg raaagacata t                                               21


<210>  4388
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4388
tttcctctag raagctgatt t                                               21


<210>  4389
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4389
cttacctctc yagatcgacc t                                               21


<210>  4390
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4390
tgatggactc yaggtgtttt c                                               21


<210>  4391
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4391
aactatatta ygttaaattt t                                               21


<210>  4392
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4392
cagtccctga ygttccttgc c                                               21


<210>  4393
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4393
ggtttgaaga rgaaggaagg a                                               21


<210>  4394
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4394
accagggaag raattaccag c                                               21


<210>  4395
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4395
atcacttatc rtgactttgc a                                               21


<210>  4396
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4396
acatgtcacc rtaagaaata a                                               21


<210>  4397
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4397
ttggaaccca raggcttatc a                                               21


<210>  4398
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4398
tggtaatgaa yagaataaaa t                                               21


<210>  4399
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4399
tcaataaaca yccccccttt a                                               21


<210>  4400
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4400
atgcaatttt ygaaaaccca t                                               21


<210>  4401
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4401
tgaggaatca rttctaattt t                                               21


<210>  4402
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4402
aatcttgaaa rtagccaaag g                                               21


<210>  4403
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4403
ctatatgtca rttccagttg t                                               21


<210>  4404
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4404
atctttaatt kaagtgattt c                                               21


<210>  4405
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4405
aagaggcagc yaccaggaat a                                               21


<210>  4406
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4406
tgagtaggta yggcatggaa t                                               21


<210>  4407
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4407
aataaagcat yatggtattt g                                               21


<210>  4408
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4408
tatgaacctc rtcattcttc a                                               21


<210>  4409
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4409
gtggtagtat kccagggctt c                                               21


<210>  4410
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4410
ccttatagaa yatagcaaca g                                               21


<210>  4411
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4411
tttattactg yaataggatt c                                               21


<210>  4412
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4412
ccactgttac kcctcggaaa a                                               21


<210>  4413
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4413
aatgaaaaag kaaattataa t                                               21


<210>  4414
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4414
cttccgaaat yctaacctag t                                               21


<210>  4415
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4415
aagaaagaat rtgggcaaag t                                               21


<210>  4416
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4416
agaggttgga ygagatgacc t                                               21


<210>  4417
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4417
tctcatttcc rgacttgctt c                                               21


<210>  4418
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4418
cttggtttcc rcatgtagta g                                               21


<210>  4419
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4419
atgccttcac rtgattagac a                                               21


<210>  4420
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4420
tgaagggata mgtgctcctt t                                               21


<210>  4421
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4421
cttgagtttg magggcaggg t                                               21


<210>  4422
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4422
gaagtatatt ktctcacttg t                                               21


<210>  4423
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4423
gactatagag rgagattcaa c                                               21


<210>  4424
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4424
agatagagag rtatatagac a                                               21


<210>  4425
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4425
agaaggattc ygtgtggaaa g                                               21


<210>  4426
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4426
cccaggtctt ytgcctgcca t                                               21


<210>  4427
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4427
cagcaggggt kgggggtaca t                                               21


<210>  4428
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4428
tacaggagaa ytggagaaag c                                               21


<210>  4429
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4429
aaggaacaaa kattggctct a                                               21


<210>  4430
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4430
ggaagggtca rtggggataa t                                               21


<210>  4431
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4431
agttcaaaga kgtcaggatt t                                               21


<210>  4432
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4432
aaatcaaaat rtcagcatta t                                               21


<210>  4433
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4433
ggaaagaaga mgtcagtgct c                                               21


<210>  4434
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4434
ttgtgtatac ygtctggatc a                                               21


<210>  4435
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4435
attgccgtag yctcagaatg a                                               21


<210>  4436
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4436
tgctagcctg yagttcagtt g                                               21


<210>  4437
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4437
ctagagttta rggtacgaga a                                               21


<210>  4438
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4438
ttcatgacac ygtactcaga g                                               21


<210>  4439
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4439
gaacagttta ygggctgcaa a                                               21


<210>  4440
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4440
aatactaaaa yggcagctac a                                               21


<210>  4441
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4441
tttttcttgc yacctcatta c                                               21


<210>  4442
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4442
ttcgtattgg rtagattttt t                                               21


<210>  4443
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4443
tagcaaactc rtaaattcga g                                               21


<210>  4444
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4444
tgtttttatt rgtttgggtc c                                               21


<210>  4445
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4445
acatcacacc rtttaaacga a                                               21


<210>  4446
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4446
cttgggttac rcttagtgga t                                               21


<210>  4447
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4447
ttacagacac rgtatatctc c                                               21


<210>  4448
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4448
tttccttgaa ygcatgtgtt t                                               21


<210>  4449
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4449
aagaatctgt rttcctgttg a                                               21


<210>  4450
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4450
tttactgggt ygtacctttt g                                               21


<210>  4451
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4451
taactaacac ytttatcttt a                                               21


<210>  4452
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4452
cccaggcaaa ycgaaaaggc t                                               21


<210>  4453
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4453
caggatgatc yggagaaaac a                                               21


<210>  4454
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4454
cctgggagac rtaaaggagt t                                               21


<210>  4455
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4455
aaactccaac mggatgatgc c                                               21


<210>  4456
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4456
taaggatatc rcggtaggaa a                                               21


<210>  4457
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4457
ccaccagggt rgtatgtacc t                                               21


<210>  4458
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4458
ttgtgtttca ratattttct c                                               21


<210>  4459
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4459
ctgtttggct kctagttctt t                                               21


<210>  4460
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4460
aataacatca yctaagcact c                                               21


<210>  4461
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4461
ctcaaaggac rtattagatt c                                               21


<210>  4462
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4462
atttgctcac rtgtatttat g                                               21


<210>  4463
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4463
tataaacagg ygtgcatcat t                                               21


<210>  4464
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4464
gcccaacatt yggattgcaa a                                               21


<210>  4465
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4465
ccaagatgag yggtcctagt t                                               21


<210>  4466
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4466
ctgtaagtct rtaagtagtt a                                               21


<210>  4467
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4467
gagatccacg kctccctaca g                                               21


<210>  4468
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4468
aatatgtgac rttttgccaa g                                               21


<210>  4469
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4469
aactcttcac ycattccttt a                                               21


<210>  4470
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4470
gtgaacctgg rtttgaatac c                                               21


<210>  4471
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4471
ggagaaagac ytcctcccaa g                                               21


<210>  4472
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4472
aagaagagga katatatata t                                               21


<210>  4473
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4473
tacaagttct ygtctcatct c                                               21


<210>  4474
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4474
gatggtcctt yccctaatga a                                               21


<210>  4475
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4475
ctactttgta yggcaatcac a                                               21


<210>  4476
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4476
ccagcaattc yaaatctagt a                                               21


<210>  4477
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4477
tggtttgaca ygtgctcaca t                                               21


<210>  4478
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4478
tccctttaac ygtaattccc a                                               21


<210>  4479
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4479
tgggggaaaa kagaattgga a                                               21


<210>  4480
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4480
gtaaacaaaa ytctaatgaa t                                               21


<210>  4481
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4481
ttattaacca ygatcttgca a                                               21


<210>  4482
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4482
tcagaatctc ygatgatggg c                                               21


<210>  4483
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4483
cttgattaca rcagatatca t                                               21


<210>  4484
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4484
ggcttccatg kttggcacga t                                               21


<210>  4485
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4485
caaataacca ycaatctgtt g                                               21


<210>  4486
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4486
gctcctcccc ygcaaagcat g                                               21


<210>  4487
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4487
acaatcaagc rctggcttca c                                               21


<210>  4488
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4488
ggaaaatagc rtaactgcag g                                               21


<210>  4489
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4489
agtaagcaga ygccttaagc a                                               21


<210>  4490
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4490
tgggaagtaa kaaattatta t                                               21


<210>  4491
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4491
ttttacaatt yattctttta c                                               21


<210>  4492
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4492
cttgaaccaa ygtgactctt g                                               21


<210>  4493
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4493
agataaagac rggaacaaga g                                               21


<210>  4494
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4494
ttatactcag yttgaagagc t                                               21


<210>  4495
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4495
ctgtataccg yttccacctt c                                               21


<210>  4496
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4496
ccacagtagt yattttatac c                                               21


<210>  4497
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4497
catataaatc ratgttctga a                                               21


<210>  4498
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4498
ctagggataa raaaagtatg c                                               21


<210>  4499
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4499
cctagagtta yctgagggtt t                                               21


<210>  4500
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4500
aacatttcac ytgcttccca a                                               21


<210>  4501
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4501
tttttcaagt kttgggaaaa g                                               21


<210>  4502
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4502
acaggaactg rcagtatgca a                                               21


<210>  4503
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4503
actttacaag ytaatggtgt t                                               21


<210>  4504
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4504
tcttttattg yctgatgtcc a                                               21


<210>  4505
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4505
ccatctttac yaaaaaatga a                                               21


<210>  4506
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4506
gcaaatgtta ytatgtttta g                                               21


<210>  4507
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4507
cacctgcaac ycctaatatg c                                               21


<210>  4508
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4508
aacacatgct rtatccagga c                                               21


<210>  4509
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4509
cgagacagac racgacaaaa a                                               21


<210>  4510
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4510
acattctaat ygtaactttg g                                               21


<210>  4511
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4511
aaaaagacta ygtgtcgttg c                                               21


<210>  4512
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4512
gagacagatc katacatgcc t                                               21


<210>  4513
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4513
acactcatca yacttttcta a                                               21


<210>  4514
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4514
gaatagcttt mtttccaatt c                                               21


<210>  4515
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4515
aaaggaagtt yaaatattct t                                               21


<210>  4516
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4516
atggtacttt magaggcaaa a                                               21


<210>  4517
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4517
gccattttgt kgggaggact c                                               21


<210>  4518
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4518
cctccttggt kcttcctatg t                                               21


<210>  4519
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4519
ttcaaagaag maggaaagaa g                                               21


<210>  4520
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4520
aggtatcaaa rtaatctata a                                               21


<210>  4521
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4521
gtatgtttat ygtgtatcct g                                               21


<210>  4522
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4522
gtacaaacat yttctaatat a                                               21


<210>  4523
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4523
aggacggaca raaaagatga g                                               21


<210>  4524
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4524
ctccaaaccg ytccatctgt g                                               21


<210>  4525
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4525
ggacttccca yggtttcctg g                                               21


<210>  4526
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4526
taattattgt kagattcgtc t                                               21


<210>  4527
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4527
cagtcattac yagctgacca a                                               21


<210>  4528
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4528
ggaattgttt ycttttcaga g                                               21


<210>  4529
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4529
gatgaaccag yaggtgagag t                                               21


<210>  4530
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4530
taagatgaaa ratggcaagc a                                               21


<210>  4531
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4531
cagaaatagg ycaaagatac c                                               21


<210>  4532
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4532
aggacaccat kcactttatt g                                               21


<210>  4533
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4533
ggtgctgtga yggcaaatcc c                                               21


<210>  4534
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4534
agtggtgagg rggttgtggc t                                               21


<210>  4535
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4535
cctggccatt ygtcacttgg g                                               21


<210>  4536
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4536
ttagtgtgcc rtggtcatga c                                               21


<210>  4537
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4537
ctgtggactg ygtctccagc c                                               21


<210>  4538
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4538
tcaagacttt maattaggag t                                               21


<210>  4539
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4539
atgtgagtaa ytctaattcc t                                               21


<210>  4540
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4540
ggaatgactg rgtcaggtgg a                                               21


<210>  4541
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4541
ctactaacat raaaagacct g                                               21


<210>  4542
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4542
aaaaatagcc kgtttccacc c                                               21


<210>  4543
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4543
aaggagctga ytgtgtgcag c                                               21


<210>  4544
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4544
cagttgggta rgggagggct g                                               21


<210>  4545
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4545
actcctctca rtatttcgct t                                               21


<210>  4546
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4546
atcatgggag rgtaggagag g                                               21


<210>  4547
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4547
tagctttgaa rtaatctccc a                                               21


<210>  4548
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4548
tgctgctgta yatttgcagt t                                               21


<210>  4549
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4549
gagctgtcgt racatagaat a                                               21


<210>  4550
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4550
ttacacagaa rgagacttac t                                               21


<210>  4551
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4551
ttttagtctt ytcattaatt a                                               21


<210>  4552
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4552
tctccattac rtgctgtgct g                                               21


<210>  4553
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4553
agggtcaggt ygggtaggag a                                               21


<210>  4554
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4554
cccacatccc yggtgagcta t                                               21


<210>  4555
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4555
ctgaccacac rctttcctga t                                               21


<210>  4556
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4556
ctcttccact mctccctgaa c                                               21


<210>  4557
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4557
aacatgggta mataggcctt c                                               21


<210>  4558
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4558
tgtgttctaa ytgaaatcag a                                               21


<210>  4559
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4559
tgaattgttc ytcttgggcc c                                               21


<210>  4560
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4560
tccgtgcccc rcatgcggcc g                                               21


<210>  4561
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4561
taaatcaaaa ytactgactt g                                               21


<210>  4562
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4562
ttcatgatgc rtccaagtgg g                                               21


<210>  4563
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4563
taggaccaca rggcaaccct t                                               21


<210>  4564
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4564
aacagagcca rtgtgaagtg c                                               21


<210>  4565
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4565
aggccactcc rctagcaagg g                                               21


<210>  4566
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4566
atttcagcac ratatataga a                                               21


<210>  4567
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4567
ctgcagtcaa kgtgtcagta g                                               21


<210>  4568
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4568
tttttataat ytccctagcc a                                               21


<210>  4569
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4569
cattctccct rtctccttca g                                               21


<210>  4570
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4570
ggcactttca rttatttgga c                                               21


<210>  4571
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4571
tgtataattt rtgagggaat g                                               21


<210>  4572
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4572
tattttcaga yttaatcaca g                                               21


<210>  4573
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4573
tctgagcaga yatattggaa t                                               21


<210>  4574
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4574
acactttttc ytcgggaata t                                               21


<210>  4575
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4575
tcttttcttt rtccttctct t                                               21


<210>  4576
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4576
ggctgcacaa rcgtagctca a                                               21


<210>  4577
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4577
agccagttac ytttaataca a                                               21


<210>  4578
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4578
gctagaagcc yagtctggtg c                                               21


<210>  4579
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4579
aagtgctttt yctttcactt c                                               21


<210>  4580
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4580
tcttttactg kgtatgcaaa c                                               21


<210>  4581
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4581
cacatttgca rcccttcaat t                                               21


<210>  4582
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4582
taatccatgc ycttgattaa t                                               21


<210>  4583
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4583
tcctaataag yccatccaaa t                                               21


<210>  4584
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4584
tggagtccct ygagttgcca t                                               21


<210>  4585
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4585
ggatctgaca rtctactgca c                                               21


<210>  4586
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4586
gatagatgga yaacttataa c                                               21


<210>  4587
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4587
ttctagtacc raaaagtaag a                                               21


<210>  4588
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4588
cgagccacac ygtaaatatt a                                               21


<210>  4589
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4589
ttttagaaca ragtgtaacg t                                               21


<210>  4590
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4590
gccataatgc raaataagcc t                                               21


<210>  4591
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4591
atatactaat maattgaagt t                                               21


<210>  4592
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4592
agaacctaat mgatacatac a                                               21


<210>  4593
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4593
tttacagcgg magaatacag g                                               21


<210>  4594
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4594
gtgggtcatt yaggaaaatt t                                               21


<210>  4595
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4595
cacatattct yatagtctaa t                                               21


<210>  4596
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4596
gctatatact kggagaaaat c                                               21


<210>  4597
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4597
aaacaaacag mtttttcttt c                                               21


<210>  4598
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4598
ttcactgctt ytgcggtttt a                                               21


<210>  4599
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4599
taaatattgt mtgggtgtat a                                               21


<210>  4600
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4600
gaatgctgtt ygtggctaac t                                               21


<210>  4601
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4601
gttgggattg mattactatc t                                               21


<210>  4602
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4602
cttgctggga rgcctgtgaa a                                               21


<210>  4603
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4603
tgcataagaa mctacactgt t                                               21


<210>  4604
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4604
gataaactct rctgaattgc c                                               21


<210>  4605
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4605
gcctgtaaag ytgggtgata a                                               21


<210>  4606
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4606
ctttcttagc raaataatct c                                               21


<210>  4607
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4607
caatctaggc rtgtgtccat c                                               21


<210>  4608
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4608
taatcataag rcaggtgaac a                                               21


<210>  4609
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4609
tctctattct rtctctgaaa t                                               21


<210>  4610
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4610
aaagacacta raaagaaagg t                                               21


<210>  4611
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4611
aagtccctac kctgctgggt g                                               21


<210>  4612
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4612
catctctcaa kgaaggcaat a                                               21


<210>  4613
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4613
tttctgggga mtttttgctg a                                               21


<210>  4614
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4614
tcgtgcctaa rtgtggttag t                                               21


<210>  4615
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4615
aagttcaaat rcagttttcc a                                               21


<210>  4616
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4616
agtgagtgta mtaaaaagaa a                                               21


<210>  4617
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4617
gcacagcatg ygacaaccaa g                                               21


<210>  4618
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4618
aatgtttact yttccatggt t                                               21


<210>  4619
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4619
ctattccctg yctgatgtcc g                                               21


<210>  4620
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4620
cttgactagg yctgaaggat t                                               21


<210>  4621
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4621
aggctttata yatctagctc t                                               21


<210>  4622
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4622
agtacatgca kctaggatct g                                               21


<210>  4623
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4623
acagtatgga rattcctcag a                                               21


<210>  4624
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4624
attttctata yttagctttc t                                               21


<210>  4625
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4625
cagcacccca mgttacagaa a                                               21


<210>  4626
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4626
tattatgaga ygcattagtg a                                               21


<210>  4627
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4627
tgtataatgc kaattacaga t                                               21


<210>  4628
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4628
ggtctcttta yaggctggct a                                               21


<210>  4629
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4629
tcaatctagg matttctgtc t                                               21


<210>  4630
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4630
ctatgactta maaatgaagt t                                               21


<210>  4631
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4631
caggaataag kaacatcaat g                                               21


<210>  4632
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4632
agtcttctct yatcacagac a                                               21


<210>  4633
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4633
gtaaatgacc rctgaataag c                                               21


<210>  4634
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4634
gaagagcctg yaacacattg t                                               21


<210>  4635
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4635
aattcattgt yagcatgagc c                                               21


<210>  4636
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4636
attgatgcaa kacattgaag a                                               21


<210>  4637
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4637
atatgcaaac rgatgaaact a                                               21


<210>  4638
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4638
tttctttgtc rttgtcagac a                                               21


<210>  4639
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4639
agtttttttc ratggtgata t                                               21


<210>  4640
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4640
ttttctcatt rggttccact a                                               21


<210>  4641
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4641
aagtaaaagc raagtgtgac g                                               21


<210>  4642
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4642
accaaactct yagaatgagc a                                               21


<210>  4643
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4643
actcactgat rgcttgattc t                                               21


<210>  4644
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4644
caaaaatgtt ygtttataga t                                               21


<210>  4645
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4645
ggattttata raaagactac t                                               21


<210>  4646
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4646
ggaacatgca rctaagtctg a                                               21


<210>  4647
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4647
atatttgaaa mtcatggagc c                                               21


<210>  4648
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4648
ttgatacttt mccccttttc c                                               21


<210>  4649
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4649
cactacacca ytatgtcatt t                                               21


<210>  4650
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4650
aagtgtgggc yttgtcacct c                                               21


<210>  4651
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4651
gcaaaaatct yactctaatt t                                               21


<210>  4652
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4652
tcgtctggac yagtttatac t                                               21


<210>  4653
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4653
gatttacagg maaaaagaga a                                               21


<210>  4654
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4654
cactgctccc rtaatagtac a                                               21


<210>  4655
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4655
gaactgtatg rgaagtacag a                                               21


<210>  4656
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4656
tgttggtcta ygtccatgga c                                               21


<210>  4657
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4657
aaatatcgtt yacctgcttt g                                               21


<210>  4658
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4658
acaaacaaaa racaccattt c                                               21


<210>  4659
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4659
gattgtctcc ragtatctca t                                               21


<210>  4660
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4660
gggaatggag ytcttttata a                                               21


<210>  4661
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4661
ccatccagcc ygaacaaaca c                                               21


<210>  4662
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4662
tgctgacctg yataccctac c                                               21


<210>  4663
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4663
agcagcatta ytggtcttct a                                               21


<210>  4664
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4664
tgggcagaga raaaggcctg t                                               21


<210>  4665
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4665
cccaccccac macccgatgc t                                               21


<210>  4666
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4666
ttatgttcat ygctagactg t                                               21


<210>  4667
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4667
tcttacctgc rtagtgttac c                                               21


<210>  4668
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4668
tggtgtttca mgtctaaggc t                                               21


<210>  4669
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4669
aaagactcaa ygggattcat c                                               21


<210>  4670
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4670
taaatgtggg yggcaaatac a                                               21


<210>  4671
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4671
ccacctcctc yttcctcttc t                                               21


<210>  4672
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4672
tttactgtgt rtcattgtat t                                               21


<210>  4673
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4673
accacacagt mtttccctca t                                               21


<210>  4674
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4674
tgaggagtgg yaacagatgt g                                               21


<210>  4675
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4675
tgagatgaag mctggagaaa g                                               21


<210>  4676
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4676
gctttcttca yttatgttcc t                                               21


<210>  4677
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4677
tgccctctgc rattttggca g                                               21


<210>  4678
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4678
tgatttggag mgtaaaatgt t                                               21


<210>  4679
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4679
gatgcacatg raactatgaa c                                               21


<210>  4680
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4680
taattccaaa yattttttac t                                               21


<210>  4681
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4681
tttgcctaca ygttcaaatt g                                               21


<210>  4682
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4682
ctctaagctg mgcaggtcct c                                               21


<210>  4683
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4683
caaaaggaac ygcttaataa t                                               21


<210>  4684
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4684
aaaaagacac ytgtaatcag t                                               21


<210>  4685
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4685
ctaggctagt kattttgcat c                                               21


<210>  4686
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4686
ttgtgtgata ytgaattact t                                               21


<210>  4687
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4687
aaggaaacta mcttgttggg a                                               21


<210>  4688
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4688
ctcaggcagg kctttttcta g                                               21


<210>  4689
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4689
aaatcctgtt ytccccctga g                                               21


<210>  4690
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4690
cttcctacat ygtttaactt t                                               21


<210>  4691
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4691
ctcagacaac mtttcgggac c                                               21


<210>  4692
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4692
aaaaataaaa rgctggtaag t                                               21


<210>  4693
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4693
cttttcaatg rgatgaatga g                                               21


<210>  4694
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4694
cagagctgta mgttagtctg t                                               21


<210>  4695
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4695
caacagggga mtgaggaatg a                                               21


<210>  4696
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4696
ggagctacaa ytatcaagaa g                                               21


<210>  4697
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4697
atacccatac rgaaacgtgg a                                               21


<210>  4698
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4698
caggcaagcc ygtgatcatg g                                               21


<210>  4699
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4699
ctgatgcagt rgtcaagata a                                               21


<210>  4700
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4700
cttgagaaaa raaacgaaag a                                               21


<210>  4701
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4701
ctcttccatt yactaaaaga a                                               21


<210>  4702
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4702
ataaaagact rtaaaagaac a                                               21


<210>  4703
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4703
cccttttagt ygtcagatgt t                                               21


<210>  4704
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4704
gacttaatac rgtctctgcc c                                               21


<210>  4705
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4705
acaacaaaaa rgagggaact a                                               21


<210>  4706
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4706
cagcagcaaa rctctatgct g                                               21


<210>  4707
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4707
taacattttt yggttatttg t                                               21


<210>  4708
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4708
aatggcaaac rtaggcttag t                                               21


<210>  4709
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4709
gctgactaac ratatcagca g                                               21


<210>  4710
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4710
tctcacctga yatcttttca g                                               21


<210>  4711
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4711
aggaatctga yaatctagtg g                                               21


<210>  4712
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4712
tcccaagtgt rttaataagg c                                               21


<210>  4713
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4713
gttcctctgc rgtggggata a                                               21


<210>  4714
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4714
aacttcagac rgaagcatgc a                                               21


<210>  4715
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4715
caaagggctt raaataaact c                                               21


<210>  4716
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4716
cttatggaaa rgtgttcaaa g                                               21


<210>  4717
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4717
gttatagggg ytcacacact g                                               21


<210>  4718
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4718
ttaaacgcca rttccaggaa g                                               21


<210>  4719
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4719
ctgtctggtc kgcacactgt t                                               21


<210>  4720
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4720
gacatttcag yaaaggctgt a                                               21


<210>  4721
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4721
agcagggtga yggcccaact c                                               21


<210>  4722
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4722
agtgtgacca rgcaaagagg c                                               21


<210>  4723
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4723
agagtctgtt ycctggggac a                                               21


<210>  4724
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4724
gtttggctca yacctgatac a                                               21


<210>  4725
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4725
ctgaggaatc ygtcctgttc a                                               21


<210>  4726
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4726
attcgggtaa ytcaggcttc t                                               21


<210>  4727
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4727
gaaagtgtcc yataacaaga g                                               21


<210>  4728
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4728
accctgaaaa rtacctctgt t                                               21


<210>  4729
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4729
tccagattcc ygggcctcag g                                               21


<210>  4730
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4730
agaccattat yataaagacg c                                               21


<210>  4731
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4731
cgagagccaa ycatgtgccc g                                               21


<210>  4732
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4732
tgctgggaag yacaagacaa a                                               21


<210>  4733
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4733
tctcatcttt rtcatgggga c                                               21


<210>  4734
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4734
ccggctgctt ygtctccagt a                                               21


<210>  4735
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4735
ctagctttgg ktctgcacat a                                               21


<210>  4736
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4736
actgttcatg mgtgtttcac a                                               21


<210>  4737
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4737
agccatcctc rcccgtccgg g                                               21


<210>  4738
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4738
gtattgggac magagcaatc t                                               21


<210>  4739
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4739
actgatgctg yttaagctgg a                                               21


<210>  4740
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4740
ggacgatgag raggacccac t                                               21


<210>  4741
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4741
agccaagtca macccaaatt a                                               21


<210>  4742
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4742
gagggggaag yacaaggaat c                                               21


<210>  4743
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4743
agctggaggc rgattatcca t                                               21


<210>  4744
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4744
tctcctcagt kttgatgctc t                                               21


<210>  4745
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4745
cagggactcc yggcccgcgc c                                               21


<210>  4746
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4746
tttcctgtct kgggcccgtg a                                               21


<210>  4747
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4747
cagcagcttc yggcagttga c                                               21


<210>  4748
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4748
ggtttcaaat yctaacactc t                                               21


<210>  4749
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4749
gatggaaagc yccagaataa a                                               21


<210>  4750
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4750
tggaaatctg rtgtcgtctg g                                               21


<210>  4751
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4751
ccagtggcaa ygaacatacc t                                               21


<210>  4752
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4752
aaaccagaag ycattagcaa t                                               21


<210>  4753
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4753
acagaatggg ktttttggct g                                               21


<210>  4754
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4754
catagctagg yggaatgtat t                                               21


<210>  4755
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4755
aagttgcttc ygtccattga c                                               21


<210>  4756
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4756
acaagaagac rgagcagagt c                                               21


<210>  4757
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4757
taccttcctc yctctgtttt c                                               21


<210>  4758
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4758
attcaaccta ytgataagtc c                                               21


<210>  4759
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4759
tttgatattt ytcaccttat t                                               21


<210>  4760
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4760
tttgtgatga kgcaatagtt c                                               21


<210>  4761
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4761
cttcggcggc mcccccgctg t                                               21


<210>  4762
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4762
ccattccttc ygcaacatct a                                               21


<210>  4763
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4763
tgcctctaac mtgggaagcc a                                               21


<210>  4764
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4764
tcgaagaaga rctcagatac c                                               21


<210>  4765
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4765
ttggttcctg ygtcattttg a                                               21


<210>  4766
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4766
actgcatgga yaattcaaca t                                               21


<210>  4767
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4767
tttttgtaga racaggttct t                                               21


<210>  4768
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4768
cagctggggg ygggtgagaa g                                               21


<210>  4769
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4769
catcaccagg kgagggaaag g                                               21


<210>  4770
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4770
ggcagtctag rgcccacact a                                               21


<210>  4771
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4771
aaccagctgc rtgcatttgg c                                               21


<210>  4772
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4772
aggctaacta yaaccgtgca g                                               21


<210>  4773
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4773
gatgatttca yaccaatcac c                                               21


<210>  4774
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4774
aggactctaa rggttataca a                                               21


<210>  4775
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4775
atggatgcca ygctaaggac g                                               21


<210>  4776
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4776
tgcatgcata yggccaccac c                                               21


<210>  4777
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4777
gtttgtgtgc mtctgtgact g                                               21


<210>  4778
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4778
caggtgtgag ragactggtg t                                               21


<210>  4779
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4779
aagagaggag ygagcacggg a                                               21


<210>  4780
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4780
acaacatggc ygccacaact a                                               21


<210>  4781
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4781
acttggggaa rgaacttcat t                                               21


<210>  4782
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4782
cagcagctgc rtatccagag g                                               21


<210>  4783
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4783
tactacctct ratgtctcag c                                               21


<210>  4784
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4784
gatgggagtg ktctgtacaa c                                               21


<210>  4785
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4785
aatgtgccat mtcttgcctg c                                               21


<210>  4786
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4786
ttctagtata kgttgctgct g                                               21


<210>  4787
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4787
gctccccttg yggccagatg c                                               21


<210>  4788
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4788
tttccactgc rttgtggctg c                                               21


<210>  4789
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4789
aagtttgttg yatgccaatt a                                               21


<210>  4790
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4790
cagcctggaa ygtttgcatc c                                               21


<210>  4791
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4791
ctccccaaaa ygtatccact c                                               21


<210>  4792
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4792
aggatctgct ycattttcct g                                               21


<210>  4793
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4793
ttagcacagg maccaatcta t                                               21


<210>  4794
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4794
gaagcatacc rtataggggg a                                               21


<210>  4795
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4795
gcatctggga raaaaataaa t                                               21


<210>  4796
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4796
atttctaata magtcctgaa a                                               21


<210>  4797
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4797
ttatgtaaat kgagactaat a                                               21


<210>  4798
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4798
cacacaaccc rgagttcagg a                                               21


<210>  4799
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4799
acatttccct mcctcagtcc a                                               21


<210>  4800
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4800
tgatgctgac rggcaaagga c                                               21


<210>  4801
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4801
tttcccattg yaatattccc c                                               21


<210>  4802
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4802
ccacagcaca rggctgatgg a                                               21


<210>  4803
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4803
agaacccagt rcttaccagg t                                               21


<210>  4804
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4804
tgagattttg yacaagacac a                                               21


<210>  4805
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4805
gctgagcagg yatccaattt g                                               21


<210>  4806
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4806
agaatacaaa ragaataaaa t                                               21


<210>  4807
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4807
gccttgatgt rgcctcctac c                                               21


<210>  4808
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4808
gattgctttc ygtactttga t                                               21


<210>  4809
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4809
tgttgtagga kgcacaagca c                                               21


<210>  4810
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4810
aggcgaggaa ratcccacag c                                               21


<210>  4811
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4811
aaattcactc rgggcacagt c                                               21


<210>  4812
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4812
gaccttcccc rtgaaggctg a                                               21


<210>  4813
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4813
tatccttgga mcctcagttc a                                               21


<210>  4814
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4814
aattcacata rcttaaggtg a                                               21


<210>  4815
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4815
caagtggtgg ytatacatgt g                                               21


<210>  4816
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4816
aaccaaaggt ragggacaca c                                               21


<210>  4817
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4817
agacccattg maaagacctc t                                               21


<210>  4818
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4818
agatatttat yggagtgtga g                                               21


<210>  4819
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4819
gtcttaatta yggtggacag t                                               21


<210>  4820
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4820
aagtggggag kgtataatga g                                               21


<210>  4821
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4821
ggggacactg ragtccatga c                                               21


<210>  4822
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4822
ctggcacttt ygagcagctg t                                               21


<210>  4823
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4823
aaactggtca yggtagctca c                                               21


<210>  4824
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4824
agcatgtaaa ktacctgacg c                                               21


<210>  4825
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4825
gtgggcagaa mcatgggccc c                                               21


<210>  4826
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4826
caaatggagc yatttcagag c                                               21


<210>  4827
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4827
tctcacacct yatagtctac a                                               21


<210>  4828
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4828
gattacttaa ygccaggctt g                                               21


<210>  4829
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4829
ggtattggaa yctcacactc a                                               21


<210>  4830
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4830
ctatcacttc rcatttttct a                                               21


<210>  4831
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4831
tgtttgtttt ygcagaatca c                                               21


<210>  4832
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4832
cttactgccc ktcctccttt t                                               21


<210>  4833
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4833
tgctcacatg kagccctcag a                                               21


<210>  4834
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4834
cttcgtgcag ygtgtctaca g                                               21


<210>  4835
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4835
tactccccca rtgtaaaact a                                               21


<210>  4836
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4836
gaatacagtg yactgacttg c                                               21


<210>  4837
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4837
aaatttataa ygacaaattc a                                               21


<210>  4838
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4838
gataaataaa ycttcattga c                                               21


<210>  4839
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4839
aaaatacggt yactctaatt t                                               21


<210>  4840
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4840
gtctaccttc rtaaagaatc t                                               21


<210>  4841
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4841
acttaaaaag yactcacttc t                                               21


<210>  4842
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4842
gactaacaac rctgtgaata t                                               21


<210>  4843
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4843
tctgaattta magcagtttc t                                               21


<210>  4844
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4844
gttcttcacc rataccagcc t                                               21


<210>  4845
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4845
tacaggcaca mactttaggg g                                               21


<210>  4846
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4846
tatgttgata kgtactgcat g                                               21


<210>  4847
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4847
ttatgaatcc rtttcagctt g                                               21


<210>  4848
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4848
ttcacctatt yaccaccata a                                               21


<210>  4849
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4849
ttgcaacatg rtggtagggt a                                               21


<210>  4850
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4850
acaatggtat mccgggttca g                                               21


<210>  4851
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4851
caagaagaca yacacaagca a                                               21


<210>  4852
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4852
tagctgtatt yagtaaatga c                                               21


<210>  4853
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4853
actagaacaa kaaatcaaat g                                               21


<210>  4854
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4854
acgaaaatac kgacacagta a                                               21


<210>  4855
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4855
accagcttat kgtcatgtct a                                               21


<210>  4856
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4856
tacttgagga yagttcttta g                                               21


<210>  4857
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4857
ttcattctcc rccactcctt c                                               21


<210>  4858
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4858
aagtgcagag ygggtgggga g                                               21


<210>  4859
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4859
aaccctcaga rgcctccaat t                                               21


<210>  4860
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4860
gtttgtgttc ycaggcccat a                                               21


<210>  4861
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4861
aacaagaaaa yttccagtca g                                               21


<210>  4862
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4862
aatttgtaaa ygtcttcccc a                                               21


<210>  4863
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4863
tgagagtgga kgacaaatgg g                                               21


<210>  4864
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4864
ccttggtaaa ytgtctctga a                                               21


<210>  4865
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4865
tgttgattca ytatacaatc a                                               21


<210>  4866
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4866
gtgttgggtt kacaaggaat g                                               21


<210>  4867
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4867
ctacctttct rcagacatac g                                               21


<210>  4868
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4868
atcttgaact kgaagggtct g                                               21


<210>  4869
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4869
gcacagaagg raagtcactg a                                               21


<210>  4870
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4870
tgcaacactc rgggccatgg g                                               21


<210>  4871
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4871
ctgttcctcc raataatcct g                                               21


<210>  4872
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4872
tctattttca kgtatatcct a                                               21


<210>  4873
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4873
gtgtgaggtg yggtactaat a                                               21


<210>  4874
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4874
agggagtcat yggagcccca c                                               21


<210>  4875
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4875
ttaacatcac ygagcaaaat c                                               21


<210>  4876
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4876
cagtcagcac ycaatcccaa g                                               21


<210>  4877
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4877
aaattatttg ytgtgaatta g                                               21


<210>  4878
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4878
ttctcaagtt rgttttagat t                                               21


<210>  4879
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4879
ttcagtcctt yctgcccacc a                                               21


<210>  4880
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4880
agtgcttgct rtctgtttat t                                               21


<210>  4881
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4881
taacaggttc rcttacctct t                                               21


<210>  4882
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4882
gtttttgttt ytagggaatc a                                               21


<210>  4883
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4883
ggcccaagtc rgcatccctt g                                               21


<210>  4884
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4884
atcccaaacc yaggaaggcc c                                               21


<210>  4885
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4885
tattgcatca ygtgtgtttt a                                               21


<210>  4886
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4886
tactgtttta yggattacta a                                               21


<210>  4887
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4887
tgtgggagga ytgaaaataa a                                               21


<210>  4888
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4888
ggaatgcgga ytgatgtttg g                                               21


<210>  4889
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4889
agtcaaaggc yttgaggcag g                                               21


<210>  4890
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4890
aagaaaactg ygtagagcat t                                               21


<210>  4891
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4891
tggctgatca rtccttctgt a                                               21


<210>  4892
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4892
tcaactactt yatctgtaag t                                               21


<210>  4893
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4893
tcaattctac rtgctaaaca t                                               21


<210>  4894
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4894
tgctaaaaag kggacagtcc t                                               21


<210>  4895
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4895
tatcatcttc ycctcaaact a                                               21


<210>  4896
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4896
ataatttccc rtattcctcc c                                               21


<210>  4897
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4897
ccacttgtac ygcatagggg a                                               21


<210>  4898
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4898
ataatttgca ragaggggta a                                               21


<210>  4899
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4899
ttggtggctt yagtgaaagc a                                               21


<210>  4900
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4900
gattcttatc ktagggctgt g                                               21


<210>  4901
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4901
tgacaggaga mttacaaact t                                               21


<210>  4902
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4902
gcccttggat ragactcttg a                                               21


<210>  4903
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4903
aaatgacatt mtgtgacttc c                                               21


<210>  4904
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4904
aaaagaaagg yttatccttt a                                               21


<210>  4905
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4905
tccacctttt yatagtcagt c                                               21


<210>  4906
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4906
ggaatgagtc yccaactaca t                                               21


<210>  4907
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4907
gttaatagtg kcagagcatg a                                               21


<210>  4908
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4908
aaacctttga yttgggttag t                                               21


<210>  4909
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4909
aaaattttgc rattgataaa t                                               21


<210>  4910
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4910
cctagtccca rcattgctca a                                               21


<210>  4911
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4911
aaatggaata rctgagattg t                                               21


<210>  4912
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4912
agactagagc ycctgtggcc a                                               21


<210>  4913
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4913
atagcctaaa yatttcttgc t                                               21


<210>  4914
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4914
tcaccataag rgacccaaca t                                               21


<210>  4915
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4915
attcacaagc yggtgtgcat a                                               21


<210>  4916
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4916
ttttcagata rgaataatga a                                               21


<210>  4917
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4917
ctgtcttccc maatgcacgc t                                               21


<210>  4918
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4918
caatcatttt rttattattt c                                               21


<210>  4919
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4919
aatgagtaca ytgatcaaat a                                               21


<210>  4920
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4920
taatgtctga ytaaatccaa g                                               21


<210>  4921
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4921
gctgtgacaa rctaagaaac t                                               21


<210>  4922
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4922
ttatttgatg rgggctgccc c                                               21


<210>  4923
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4923
aaggatagaa raagatatcc c                                               21


<210>  4924
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4924
tttatttcat kgcgtataaa a                                               21


<210>  4925
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4925
gctgatcgca rttttcataa a                                               21


<210>  4926
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4926
tacatagtga ycagagttgt c                                               21


<210>  4927
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4927
gggtcataaa magttgttct c                                               21


<210>  4928
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4928
aaatgttctg yttaaagtgg a                                               21


<210>  4929
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4929
ggaagcctcc rggtaatgcc c                                               21


<210>  4930
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4930
gtggttaaag rgaaggaagt t                                               21


<210>  4931
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4931
acctgccccc mtatcccaag g                                               21


<210>  4932
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4932
attgagtttt kcagttattg t                                               21


<210>  4933
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4933
acataggcaa rtaacaagcg t                                               21


<210>  4934
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4934
gtatttacgc ytcctggaga t                                               21


<210>  4935
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4935
tggccacacc rttaccttac t                                               21


<210>  4936
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4936
gaacagcttc ratgcattaa t                                               21


<210>  4937
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4937
atatttatac ycacttgtaa g                                               21


<210>  4938
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4938
cttcctactt ygtttcctgt g                                               21


<210>  4939
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4939
tttgggaata matccatacc t                                               21


<210>  4940
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4940
aaaataatac rtctgggatt t                                               21


<210>  4941
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4941
caagattaaa ycaaccttgg a                                               21


<210>  4942
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4942
cctgtgctgt rgtagaaaga g                                               21


<210>  4943
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4943
atttcatatc ytaatggaac t                                               21


<210>  4944
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4944
gtgtaattaa yagtgccccc t                                               21


<210>  4945
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4945
gcaagccagc rggccagtgg a                                               21


<210>  4946
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4946
aatgaaacta raccccatgt c                                               21


<210>  4947
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4947
tgttctccaa maaagataaa a                                               21


<210>  4948
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4948
ccaacattct rttttctccc t                                               21


<210>  4949
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4949
ctccctaagt rgggtgcggg a                                               21


<210>  4950
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4950
ttcctctcat ygttttcccc c                                               21


<210>  4951
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4951
tttgctttcc rgtttaaaaa a                                               21


<210>  4952
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4952
gtggctttct rccttcaggt g                                               21


<210>  4953
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4953
tacatttgga rtagcactgt t                                               21


<210>  4954
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4954
tcatgcatcc yatacatagc c                                               21


<210>  4955
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4955
aaaccctaca rtggcttcac t                                               21


<210>  4956
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4956
agcatttcat ytccactaaa a                                               21


<210>  4957
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4957
caaagggaaa ygacatgctt g                                               21


<210>  4958
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4958
ctacatgtgt ytagtgagta t                                               21


<210>  4959
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4959
acactgaaca rgcggtaact g                                               21


<210>  4960
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4960
atgattggtt yaggggcaat t                                               21


<210>  4961
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4961
aactggctgg rcgtggtggc t                                               21


<210>  4962
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4962
tacatgaatg ytcttttaat g                                               21


<210>  4963
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4963
aaaagaaatc raaaggtcca t                                               21


<210>  4964
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4964
cttggtattt kttcattctc c                                               21


<210>  4965
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4965
tcttttcttt rccatcagac t                                               21


<210>  4966
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4966
aatttaagat rttgaaagga a                                               21


<210>  4967
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4967
ttcatatcaa rtttctttct t                                               21


<210>  4968
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4968
gaggcaatgt ytgaatggca a                                               21


<210>  4969
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4969
attttggcat ytgtgtgcca t                                               21


<210>  4970
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4970
tcagagaagt yataaaatat g                                               21


<210>  4971
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4971
gctagggaac mgggtccctc c                                               21


<210>  4972
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4972
atttctgacc yacagaaatt a                                               21


<210>  4973
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4973
ggtattttgg mctcggtagt g                                               21


<210>  4974
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4974
ctgttgaatt rcccatcttc t                                               21


<210>  4975
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4975
aaggtaagag rtcaaaatcc t                                               21


<210>  4976
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4976
atttcagtcc mtctgttttt t                                               21


<210>  4977
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4977
ttcctggaga rctggactca t                                               21


<210>  4978
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4978
ggtggtagaa rgcataacat g                                               21


<210>  4979
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4979
actaatacgt rcaataatga c                                               21


<210>  4980
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4980
caagaggcag ratgtaaact g                                               21


<210>  4981
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4981
gagctgcctc rtgcacaaaa g                                               21


<210>  4982
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4982
ccatcatatc ygcagtgact a                                               21


<210>  4983
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4983
cacggctgga ygctgctctc a                                               21


<210>  4984
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4984
ttgaaaatca rattgaaaca g                                               21


<210>  4985
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4985
tcaaaagaca yttgcttgaa a                                               21


<210>  4986
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4986
tttctactat katttaattg c                                               21


<210>  4987
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4987
atggaaactg rtttaaaaaa t                                               21


<210>  4988
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4988
tcttcatgtt rtgaatgggc c                                               21


<210>  4989
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4989
tttgaaaaac ycagataggc a                                               21


<210>  4990
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4990
ctcccagctg ygggagggat c                                               21


<210>  4991
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4991
gacaatgagg ygttgtaggg g                                               21


<210>  4992
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4992
ttatttgtag ytcagacctc t                                               21


<210>  4993
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4993
aagcatagga ytggtttggg g                                               21


<210>  4994
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4994
gatgcagctg yagacgttgt a                                               21


<210>  4995
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4995
gttgggaaac raatcatcta t                                               21


<210>  4996
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4996
ttgtatctgt rctaggttag a                                               21


<210>  4997
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4997
ctggtaccaa mgcaaccaag t                                               21


<210>  4998
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4998
agctgctgat ygtcccttgt t                                               21


<210>  4999
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  4999
tgtactggtg ygatgccaag c                                               21


<210>  5000
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5000
ggaatcatga rctgcaaagc t                                               21


<210>  5001
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5001
catcagtaat ragagtaaac a                                               21


<210>  5002
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5002
atgaatagtc rtaaacataa a                                               21


<210>  5003
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5003
tgtgttctca yatggccttc c                                               21


<210>  5004
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5004
atttctctga yaatgtttta a                                               21


<210>  5005
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5005
atttctttga yctggacaga a                                               21


<210>  5006
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5006
tctaacataa ytgacatggt t                                               21


<210>  5007
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5007
ttaagtggct rcacttatga a                                               21


<210>  5008
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5008
agtttttcat yccccaaaga a                                               21


<210>  5009
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5009
caaataaaac rtagcagaga a                                               21


<210>  5010
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5010
tactagtatc yggcaggcgt g                                               21


<210>  5011
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5011
tggccttctt rgtttttgtc g                                               21


<210>  5012
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5012
ttcaaagctc kgtgcatgtg c                                               21


<210>  5013
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5013
agaaaaaata ktaacctgag c                                               21


<210>  5014
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5014
ttttttttag yccaagaaca a                                               21


<210>  5015
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5015
tagatgcttt yatgagtctc t                                               21


<210>  5016
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5016
acattggcca mgtacaagca a                                               21


<210>  5017
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5017
tatcaaacac katattgcaa t                                               21


<210>  5018
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5018
ttttttctct ygacccaaat g                                               21


<210>  5019
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5019
cttgatttta raactcttgc t                                               21


<210>  5020
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5020
aggcaatctg rgctgcacca g                                               21


<210>  5021
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5021
agattaacat kcggacatta a                                               21


<210>  5022
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5022
tctttgtgcc yttaagaatc t                                               21


<210>  5023
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5023
attgagtgga yattgggcca g                                               21


<210>  5024
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5024
caagccttga rtgtgataat a                                               21


<210>  5025
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5025
atcattaact ygctttcaga g                                               21


<210>  5026
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5026
ccagttctct rtatgcttgg g                                               21


<210>  5027
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5027
tactactcta yaaagcgtgc a                                               21


<210>  5028
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5028
ttctgacgac ygttgagaaa a                                               21


<210>  5029
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5029
gaaatagcac rtggaattaa g                                               21


<210>  5030
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5030
gtcaaacccc ygtacaaaaa c                                               21


<210>  5031
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5031
agtcccagac kataaattat g                                               21


<210>  5032
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5032
cttttacttc rtgtcaaact c                                               21


<210>  5033
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5033
accacatgga rtatgggatg t                                               21


<210>  5034
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5034
ttttgttaac yacaaatacg a                                               21


<210>  5035
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5035
agtcaattca racttggaga a                                               21


<210>  5036
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5036
tgtattcaga ycagcccagc t                                               21


<210>  5037
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5037
atgagatgaa yaggagcttt g                                               21


<210>  5038
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5038
gatacatggc kattgacttt a                                               21


<210>  5039
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5039
aatgcaatta ygaaaaagtc t                                               21


<210>  5040
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5040
ttcaagcatc yggttaaact t                                               21


<210>  5041
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5041
gtgtgagtgt ycagccttgt g                                               21


<210>  5042
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5042
caacctcagg yagtgcagct t                                               21


<210>  5043
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5043
attgttattt kggagaacct c                                               21


<210>  5044
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5044
accagaattc rtttgtatat t                                               21


<210>  5045
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5045
cagggggagg ygggagacat a                                               21


<210>  5046
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5046
gcttattgaa kgtggtgatg g                                               21


<210>  5047
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5047
aaaataaaca kgggaatagg c                                               21


<210>  5048
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5048
gcccacagat ktggtgtttg g                                               21


<210>  5049
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5049
tgcttcaagc mactgatttt c                                               21


<210>  5050
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5050
tcaaagctgg kttgaaagcc a                                               21


<210>  5051
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5051
tcaagggaca ygtaaataag a                                               21


<210>  5052
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5052
gagatcttat mcaactgtct t                                               21


<210>  5053
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5053
ttgccatcag rgaaagctgg a                                               21


<210>  5054
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5054
acaacgccac rcatgaaaat g                                               21


<210>  5055
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5055
aaaaacatgt ktacagacca g                                               21


<210>  5056
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5056
gagtggcttc rtagggctgc a                                               21


<210>  5057
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5057
ttgggtaatc racactccga g                                               21


<210>  5058
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5058
gatcctcttc kgatcatctg a                                               21


<210>  5059
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5059
ttactctgac yattcctcca a                                               21


<210>  5060
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5060
actaccaggt ygtaaatcct t                                               21


<210>  5061
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5061
aaacaaaata ytataaactg g                                               21


<210>  5062
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5062
tttgaccttg rtttttataa t                                               21


<210>  5063
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5063
attatgtcat rgggtccaca g                                               21


<210>  5064
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5064
tgtaagtaat ragggagtaa c                                               21


<210>  5065
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5065
cttttttcag rgtaaggtga t                                               21


<210>  5066
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5066
catgcataac rtgtgttaaa t                                               21


<210>  5067
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5067
aaatgtctaa ygagagggag g                                               21


<210>  5068
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5068
tctctttctc mattttttca a                                               21


<210>  5069
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5069
atagctttta magatcattc t                                               21


<210>  5070
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5070
actaactcca ratagttccc c                                               21


<210>  5071
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5071
ataacaccta yagttgacga t                                               21


<210>  5072
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5072
aagtttattt kgtgaccata t                                               21


<210>  5073
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5073
aggtatctta yaacagagta t                                               21


<210>  5074
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5074
ttcaacctac ygatgagcat a                                               21


<210>  5075
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5075
tagaaggctg magaaatatc g                                               21


<210>  5076
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5076
catagggatg ygagtgaaag g                                               21


<210>  5077
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5077
tttaattcac rtttaacgtt a                                               21


<210>  5078
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5078
atggtagaaa mgtatataga g                                               21


<210>  5079
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5079
attgtcctca rcttggtatc t                                               21


<210>  5080
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5080
ttgtatccta ygacagtgcc t                                               21


<210>  5081
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5081
aggtttgttg rcaccaacat c                                               21


<210>  5082
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5082
tctctcctct ytcatgcgtc a                                               21


<210>  5083
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5083
cctggatagc rtctgatgac a                                               21


<210>  5084
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5084
caaagatgag ktggcaaaga g                                               21


<210>  5085
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5085
ctcttatctt yacacattca t                                               21


<210>  5086
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5086
caaggagcat rgttaacctg t                                               21


<210>  5087
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5087
ctttcataat ycttaacact t                                               21


<210>  5088
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5088
aatggcaaat kcttgatttt a                                               21


<210>  5089
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5089
tcatcctggt rttctccaaa g                                               21


<210>  5090
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5090
tcaggtgtaa rtgatctttc a                                               21


<210>  5091
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5091
agagttatca rtggaggtat t                                               21


<210>  5092
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5092
agtttactta yacttgttta t                                               21


<210>  5093
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5093
tcatctgaga yttggtgccc t                                               21


<210>  5094
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5094
gattagtgag kttgagtacc t                                               21


<210>  5095
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5095
gcattgtata maatttctaa t                                               21


<210>  5096
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5096
aagtctcttt rctcaagtga a                                               21


<210>  5097
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5097
tctccctcaa rctcatttct t                                               21


<210>  5098
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5098
tgccttattc ygctcttatt c                                               21


<210>  5099
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5099
gtttttaatc rtcagctttc t                                               21


<210>  5100
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5100
gccaccaggc ratagagaat g                                               21


<210>  5101
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5101
agatggtgat rggagtgaag g                                               21


<210>  5102
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5102
gtggagcctt yagaaatatc t                                               21


<210>  5103
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5103
acagtagtct rgactaggaa a                                               21


<210>  5104
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5104
tatttggttc rtactaggat t                                               21


<210>  5105
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5105
atcctgtctt mtgcacgagg g                                               21


<210>  5106
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5106
cagaaagagg yaaagcaaga c                                               21


<210>  5107
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5107
ttccatctcc rtaaagtgac a                                               21


<210>  5108
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5108
ggtagtttag ytcattatag t                                               21


<210>  5109
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5109
ttgagattgc ytctaaattt t                                               21


<210>  5110
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5110
caatgtgttt yagagtggga g                                               21


<210>  5111
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5111
tacttcagta rcatttttct a                                               21


<210>  5112
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5112
ctccctcaag yatagtctcc c                                               21


<210>  5113
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5113
tagaataaaa kttagtccag a                                               21


<210>  5114
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5114
tccaaattgg raaatggagc a                                               21


<210>  5115
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5115
tttttagaac mattcctcac c                                               21


<210>  5116
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5116
attatattta ktcattcaaa c                                               21


<210>  5117
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5117
gattacatag yttactgctg a                                               21


<210>  5118
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5118
ttgccaccga kgcatagagg c                                               21


<210>  5119
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5119
tgagacattc rgaatttcgt t                                               21


<210>  5120
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5120
aattgacttt mgatcagcca a                                               21


<210>  5121
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5121
agccaggctg ycagttttca c                                               21


<210>  5122
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5122
taacgtcaaa rgaaagggca a                                               21


<210>  5123
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5123
cctcctttag rcacaaattg a                                               21


<210>  5124
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5124
cagaatcctc yccttgcttc t                                               21


<210>  5125
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5125
tggtgcaaac rtacctagat t                                               21


<210>  5126
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5126
actttcccta yagcaagctg g                                               21


<210>  5127
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5127
ataataaccc yttgcaagta c                                               21


<210>  5128
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5128
tccttctgtg kcttctttga c                                               21


<210>  5129
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5129
ttcctcattc mtgtttcatc t                                               21


<210>  5130
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5130
cattgtatac rtgtgcactt g                                               21


<210>  5131
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5131
aaacttccca katttttact t                                               21


<210>  5132
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5132
tctgtaacca yggcatattg g                                               21


<210>  5133
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5133
actcaactcc yaatgcttca c                                               21


<210>  5134
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5134
catatttcat yctactaact c                                               21


<210>  5135
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5135
ttaaacacag ytggattatt t                                               21


<210>  5136
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5136
gtgataagca raaagaggtc a                                               21


<210>  5137
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5137
attatgagac mcagtaacaa c                                               21


<210>  5138
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5138
tatctagatt ygacctctgt g                                               21


<210>  5139
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5139
ttgttacaat rctatgtgaa t                                               21


<210>  5140
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5140
caacatcgca rcaacaagtc a                                               21


<210>  5141
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5141
atatccaagc rtatcagtaa g                                               21


<210>  5142
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5142
ctgtttcaca yttccatggt g                                               21


<210>  5143
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5143
tctacatctg yggttgtagt t                                               21


<210>  5144
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5144
tttattccca ycacatttct t                                               21


<210>  5145
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5145
ctctcagtaa rttagttccc a                                               21


<210>  5146
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5146
cagtcacgtt ktcaaatagc t                                               21


<210>  5147
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5147
agagctgaaa raaaaggaaa t                                               21


<210>  5148
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5148
cacttaaatc ygaaatatga t                                               21


<210>  5149
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5149
tagaatacac yttagctgat g                                               21


<210>  5150
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5150
aatcttgaca yttttttcac a                                               21


<210>  5151
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5151
gaagtcctag mtctcctttt g                                               21


<210>  5152
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5152
attctccctt rgggcacttg a                                               21


<210>  5153
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5153
agtaaggtga ragctcagag a                                               21


<210>  5154
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5154
aaatcatcaa rtggttagag t                                               21


<210>  5155
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5155
actttagaga rtggttaagt g                                               21


<210>  5156
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5156
tttaaattgg macttcccct g                                               21


<210>  5157
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5157
catctgtgat rttcctcaag c                                               21


<210>  5158
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5158
ctttgacatg kcatcaccaa t                                               21


<210>  5159
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5159
agtaaaataa ratctacaat a                                               21


<210>  5160
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5160
gtagacttct yctgaggtct c                                               21


<210>  5161
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5161
caaagtaacc ratatttcca t                                               21


<210>  5162
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5162
agttatacaa yttcacctct c                                               21


<210>  5163
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5163
tgtactaaag rcctccacag c                                               21


<210>  5164
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5164
agggaagata rtttccaaca t                                               21


<210>  5165
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5165
acccttcttg rcctcaactc t                                               21


<210>  5166
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5166
gttgagagaa ygtgataatt c                                               21


<210>  5167
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5167
ctggtattca rtctcccctt t                                               21


<210>  5168
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5168
gatggtcaca ygctaaggaa t                                               21


<210>  5169
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5169
tctggattct raggataaag c                                               21


<210>  5170
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5170
gtcttttcaa rtcatcaaac a                                               21


<210>  5171
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5171
ctatgttcca yttccctaga t                                               21


<210>  5172
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5172
gtcatttcac yctccagcac a                                               21


<210>  5173
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5173
aaggcagttt yaggattgtg t                                               21


<210>  5174
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5174
aatatggaag kggcttaaag a                                               21


<210>  5175
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5175
agtagcaccc yttttgactt t                                               21


<210>  5176
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5176
agggaaatgc yggtaagaga t                                               21


<210>  5177
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5177
cccatgtgac ycacacctga a                                               21


<210>  5178
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5178
taagtttgag rggaatcaaa a                                               21


<210>  5179
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5179
ggaatgggag katcgccaag a                                               21


<210>  5180
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5180
gctatttaca ygaaatgaaa c                                               21


<210>  5181
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5181
aatcttaaaa ytcagggacc c                                               21


<210>  5182
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5182
tagttgcata rgcaaagaag t                                               21


<210>  5183
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5183
gtgaatgata ygcttaaaat a                                               21


<210>  5184
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5184
tatactagtc raaatccatt g                                               21


<210>  5185
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5185
tacaaccagg mgttctccta t                                               21


<210>  5186
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5186
ggaagttatc rccccataga a                                               21


<210>  5187
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5187
caacagagaa rtgatgactg g                                               21


<210>  5188
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5188
tctgtatgaa ygctacgaat g                                               21


<210>  5189
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5189
ctgcctcggc mtctcaaagc a                                               21


<210>  5190
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5190
cacgttttcc rgtttcaaga t                                               21


<210>  5191
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5191
ttaaaaaaaa matcaaggaa c                                               21


<210>  5192
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5192
taaggtaacc rgtttactat g                                               21


<210>  5193
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5193
cctataaaaa yaatcaactg a                                               21


<210>  5194
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5194
tttgaacata ytggaaataa a                                               21


<210>  5195
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5195
tttttttttt kggtaaggag a                                               21


<210>  5196
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5196
gaaaaactaa ragaatctca a                                               21


<210>  5197
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5197
ttctaagaat ytgatttaaa a                                               21


<210>  5198
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5198
ccagcctata rtgttccagc t                                               21


<210>  5199
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5199
tgtcacagcc rtatcacaga t                                               21


<210>  5200
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5200
tccgccttgc mgattttcat a                                               21


<210>  5201
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5201
gttttgttcc raggaagata t                                               21


<210>  5202
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5202
acaaaggata magatgaata g                                               21


<210>  5203
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5203
ttatgaggga mgttcacttt c                                               21


<210>  5204
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5204
gcccagggat yatgaagcca g                                               21


<210>  5205
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5205
cggtttcgca ygttagcagt c                                               21


<210>  5206
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5206
tatcccataa ytatatatga t                                               21


<210>  5207
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5207
tttccacagt yagctgccat t                                               21


<210>  5208
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5208
ttaacactgc rcgaagcagg a                                               21


<210>  5209
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5209
gacttattgc ycagctgaga g                                               21


<210>  5210
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5210
aggctagaaa rcataaaaac a                                               21


<210>  5211
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5211
gggctgctta yctttaaccc t                                               21


<210>  5212
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5212
cacaaaaaaa mcaccctttc t                                               21


<210>  5213
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5213
tttctatgca ragaaagctg a                                               21


<210>  5214
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5214
agagcagttc yttaagttta g                                               21


<210>  5215
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5215
ctggacaggg raagtcttca c                                               21


<210>  5216
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5216
ggctccttag mggtaatggc t                                               21


<210>  5217
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5217
tcggacataa yatttcactg t                                               21


<210>  5218
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5218
ttcaacttac rattttttga c                                               21


<210>  5219
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5219
ctgcttcttt yaagtctgaa a                                               21


<210>  5220
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5220
ttgtattggt yctattttga g                                               21


<210>  5221
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5221
tcctaagaat rgtgagcaaa c                                               21


<210>  5222
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5222
cttcctgctt ygtgagtcct c                                               21


<210>  5223
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5223
gataaaggag mttaaacttt t                                               21


<210>  5224
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5224
aaaagcccaa ytgcttcctt t                                               21


<210>  5225
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5225
ataccaacta ygctggcttt a                                               21


<210>  5226
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5226
tcctcaacaa yggatagctt t                                               21


<210>  5227
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5227
ttatgttaat ytgatgcaaa g                                               21


<210>  5228
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5228
gggagaagtc rcagcgaatt t                                               21


<210>  5229
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5229
gattttatga yaaaacaacc a                                               21


<210>  5230
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5230
aacagcctac rttagatact a                                               21


<210>  5231
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5231
gtgaaaatta ytaattgcat a                                               21


<210>  5232
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5232
ttgcctttct yatgtgacct g                                               21


<210>  5233
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5233
gacttaaagt rtcgacagtc a                                               21


<210>  5234
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5234
taagtctaac rtgtgctcag a                                               21


<210>  5235
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5235
tattgtcatc yactaagata t                                               21


<210>  5236
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5236
gcataagtct rtggaagaaa a                                               21


<210>  5237
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5237
cctatcttta ytgatgtatt a                                               21


<210>  5238
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5238
cattatcttt rgaagcttaa g                                               21


<210>  5239
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5239
ggacatagaa rtcaaagagt t                                               21


<210>  5240
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5240
gtgagtgggc ygtatgacaa g                                               21


<210>  5241
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5241
tatgacaagt yacaggggct g                                               21


<210>  5242
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5242
tttgaacatc ygctgagatt a                                               21


<210>  5243
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5243
acaaaagtcc rgtcaagtca c                                               21


<210>  5244
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5244
ccagtgccca rccctgccct c                                               21


<210>  5245
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5245
atactaccta mtcattagtc a                                               21


<210>  5246
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5246
accttggtat kgcagttgtg t                                               21


<210>  5247
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5247
ggcaaactca kcttcatcag t                                               21


<210>  5248
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5248
aatcacaaac rtatatttcc a                                               21


<210>  5249
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5249
atgagctaga ytattaaatt c                                               21


<210>  5250
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5250
gtgacaactt mcgtccacta a                                               21


<210>  5251
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5251
agcacaggca yttaactagt g                                               21


<210>  5252
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5252
cataatcaga mtctaagaga a                                               21


<210>  5253
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5253
agaacacatt yagagccttt c                                               21


<210>  5254
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5254
gatgtgtcac ygaccctttc t                                               21


<210>  5255
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5255
agggatccca yatctagaaa a                                               21


<210>  5256
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5256
gagatcaacc ycatcagccc t                                               21


<210>  5257
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5257
ctctgggctt yaggatgaga g                                               21


<210>  5258
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5258
agagacagtc ygtaaagatt c                                               21


<210>  5259
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5259
ttagtgtgca yggttgcaga g                                               21


<210>  5260
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5260
tagatgtaac rgaggccaac a                                               21


<210>  5261
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5261
taggggtaca ktttcccttg c                                               21


<210>  5262
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5262
ggaagatgga ygtccgtgga g                                               21


<210>  5263
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5263
ttagaatcta ygagctcatc t                                               21


<210>  5264
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5264
ctggaggttt rcagggctgc a                                               21


<210>  5265
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5265
ttttgagcca mcaagaaaat c                                               21


<210>  5266
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5266
actattgaga ygtcaagtct t                                               21


<210>  5267
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5267
ttggaacatt kcttattcgt g                                               21


<210>  5268
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5268
ctttcgcatt ycccatcttt g                                               21


<210>  5269
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5269
ttaactcttc rgctatttct a                                               21


<210>  5270
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5270
atacttagat ytcaactcta a                                               21


<210>  5271
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5271
acttgtaaat rtagaagaaa t                                               21


<210>  5272
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5272
aactttcaac ytgtttaaat t                                               21


<210>  5273
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5273
cctggagatg yagaaatgga a                                               21


<210>  5274
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5274
ggcccctttt ractgctctg c                                               21


<210>  5275
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5275
ctgaacccag rtgtggcctt c                                               21


<210>  5276
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5276
ttgattacta rgagctcttt c                                               21


<210>  5277
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5277
gtttctgctg rggacatctc a                                               21


<210>  5278
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5278
gttgaaaagg ycattgccta a                                               21


<210>  5279
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5279
ggataccttt ragcctgtaa a                                               21


<210>  5280
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5280
attgttttca yagggcccaa a                                               21


<210>  5281
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5281
cgccaaaaca rcggggaatg a                                               21


<210>  5282
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5282
aaggaaactc racaaatatc t                                               21


<210>  5283
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5283
gttatgattc ygatttagag t                                               21


<210>  5284
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5284
tgaggaggat rgagtctgtt t                                               21


<210>  5285
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5285
gcggaaaggg ragcggcggg a                                               21


<210>  5286
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5286
gattagggac rtaaatgatc a                                               21


<210>  5287
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5287
aattctatgc rtgttactgg t                                               21


<210>  5288
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5288
ctttgtcctt kacctttaga a                                               21


<210>  5289
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5289
ttttccttgt rtttttctgg t                                               21


<210>  5290
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5290
gaaaaagaga rgggcttttt a                                               21


<210>  5291
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5291
atatattgat kctacttttt c                                               21


<210>  5292
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5292
ggaaaacagc yccctagact c                                               21


<210>  5293
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5293
gaaaacagcc ycctagactc t                                               21


<210>  5294
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5294
cgttgttttc ygccatttat c                                               21


<210>  5295
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5295
tgagtaacta rcacacttaa a                                               21


<210>  5296
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5296
tgacctaatt rccactcaaa g                                               21


<210>  5297
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5297
taggatggac yacaattctt t                                               21


<210>  5298
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5298
ttcctgaaca ytagagcagt t                                               21


<210>  5299
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5299
ttcagactca rtcaaggcaa g                                               21


<210>  5300
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5300
ggctgcaggg rtatcaaaat g                                               21


<210>  5301
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5301
ttaatacata rattgctttt c                                               21


<210>  5302
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5302
aagaagaggg raaagatagt t                                               21


<210>  5303
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5303
cactcatcat rcttcagcca c                                               21


<210>  5304
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5304
gaacagtccc ygatgtgtag g                                               21


<210>  5305
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5305
tgagacacag ytcctgctat c                                               21


<210>  5306
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5306
taggtcaaat kttgtacccc t                                               21


<210>  5307
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5307
tatgcacatc ygacatttaa g                                               21


<210>  5308
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5308
taactcaagt yacataattt a                                               21


<210>  5309
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5309
gatgaagatg rccttacttc t                                               21


<210>  5310
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5310
tcggaggacc kagagggcac t                                               21


<210>  5311
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5311
gtaaaaccta mattttagaa t                                               21


<210>  5312
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5312
accaggcaac ygttaactgt a                                               21


<210>  5313
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5313
caagttgatg ytatggatcc a                                               21


<210>  5314
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5314
cagtgttcct kacagtaagt a                                               21


<210>  5315
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5315
tctgaggaag rcagctgtgc a                                               21


<210>  5316
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5316
ttagcagcca ygctgcactg g                                               21


<210>  5317
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5317
gcttaggtgt rcgttgaagt a                                               21


<210>  5318
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5318
cagttgatga matttaggtg g                                               21


<210>  5319
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5319
ttcctctcca rtactccagt c                                               21


<210>  5320
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5320
ggaaatggca yttttagaag c                                               21


<210>  5321
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5321
aaaaatggaa kagtcatctc a                                               21


<210>  5322
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5322
cagcatccag kcaccatctg t                                               21


<210>  5323
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5323
aatagttagc ktcaaacagg t                                               21


<210>  5324
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5324
atctaaggac mttgtagaga c                                               21


<210>  5325
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5325
ggaatggtgg ygagagggga a                                               21


<210>  5326
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5326
ctgtgctatt ktagaattac c                                               21


<210>  5327
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5327
cctggagaac kgaagacatt t                                               21


<210>  5328
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5328
gtacattttc raggccttag g                                               21


<210>  5329
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5329
aacaggcact raaagaaaga c                                               21


<210>  5330
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5330
actaacctct mtggaattat a                                               21


<210>  5331
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5331
tggttttgtt ygtttgactg t                                               21


<210>  5332
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5332
caaagccagc rtgctctgca t                                               21


<210>  5333
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5333
atcctgaaca rgggggttca a                                               21


<210>  5334
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5334
tgtttcatag rcatgtatga a                                               21


<210>  5335
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5335
tggtacttct ycagggaacg a                                               21


<210>  5336
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5336
cccatcttac mtcccaactc a                                               21


<210>  5337
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5337
tactggtagg ygccagtagt a                                               21


<210>  5338
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5338
ctttccccac kttacaaatg a                                               21


<210>  5339
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5339
aaggaaaagt raaggaaata a                                               21


<210>  5340
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5340
ttttttaatg rcaaataagt t                                               21


<210>  5341
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5341
ccatggatgg rtgccttttc t                                               21


<210>  5342
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5342
ggtgagctag ytcctggacc t                                               21


<210>  5343
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5343
aactgcgcag rcagcagcgt t                                               21


<210>  5344
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5344
tgaattatta yagggattag c                                               21


<210>  5345
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5345
tactttagag rtcaatagtg a                                               21


<210>  5346
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5346
tgggttagaa ratcacctgg g                                               21


<210>  5347
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5347
ttgcagaaac macaacatga g                                               21


<210>  5348
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5348
agaatcatgt matctgtgct g                                               21


<210>  5349
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5349
ctcctttctt magagttaga c                                               21


<210>  5350
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5350
agaacctagg macattcaaa t                                               21


<210>  5351
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5351
atcaacttgc ytggagcgta t                                               21


<210>  5352
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5352
acatgctcca rttcaaccta a                                               21


<210>  5353
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5353
acacagaacc ratgcagttt g                                               21


<210>  5354
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5354
ctctgccagt kaggtaggaa a                                               21


<210>  5355
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5355
tctaagaagt ygatatatta a                                               21


<210>  5356
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5356
tgcaattttt rtccattaac c                                               21


<210>  5357
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5357
gggccttttg mgcttcctgg a                                               21


<210>  5358
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5358
gctgtaacca rtgtcagtga t                                               21


<210>  5359
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5359
ccccaggaag ratgcgcttt a                                               21


<210>  5360
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5360
aaacagcccc rtgagataga c                                               21


<210>  5361
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5361
agggatattg rtagtttttc t                                               21


<210>  5362
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5362
agcaattctc ragtattctt c                                               21


<210>  5363
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5363
ggtgataagc rcagtaacca t                                               21


<210>  5364
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5364
tgataaaggg rgaactttgg g                                               21


<210>  5365
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5365
attgcaataa ractcagacc a                                               21


<210>  5366
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5366
tatggtgtgc yttttcagta t                                               21


<210>  5367
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5367
attaactgct rttaaggacc a                                               21


<210>  5368
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5368
agaaggaaac rtagagatca t                                               21


<210>  5369
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5369
tgtagatcaa rcaggctttg t                                               21


<210>  5370
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5370
caatggggca rcataattag t                                               21


<210>  5371
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5371
ggacagggcc rctggggtga a                                               21


<210>  5372
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5372
aaatctcctg racttgtcac t                                               21


<210>  5373
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5373
ctgaagtttc raggagggca a                                               21


<210>  5374
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5374
tacctaaacc rcacctactc c                                               21


<210>  5375
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5375
ttatgacaat ytgcatcagt c                                               21


<210>  5376
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5376
catatattgg raatctttct a                                               21


<210>  5377
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5377
acccaggcag ytggaactta c                                               21


<210>  5378
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5378
aaacatggct yctgccgtca a                                               21


<210>  5379
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5379
tgtcttctcc matttgagaa t                                               21


<210>  5380
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5380
cataatttac yatttatgaa g                                               21


<210>  5381
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5381
aaatggtgaa rcagcatttt a                                               21


<210>  5382
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5382
gcaggactgg ktagtgaaca t                                               21


<210>  5383
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5383
atggttttac rtaaatgttc t                                               21


<210>  5384
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5384
agggtaactc ratattgtga g                                               21


<210>  5385
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5385
acagagtcta rggaataaat a                                               21


<210>  5386
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5386
ttctcaagta yagtttagtg g                                               21


<210>  5387
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5387
cgagcaaaag ktgctggaaa t                                               21


<210>  5388
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5388
gtgtctccac rcccatattt c                                               21


<210>  5389
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5389
attgtttcca yttgacctcc a                                               21


<210>  5390
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5390
attgttaaca mtgattacct t                                               21


<210>  5391
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5391
ccaggccaga yggggttcag g                                               21


<210>  5392
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5392
ctaggggatg ktggatggca c                                               21


<210>  5393
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5393
ataaattgtg ytggaacaat c                                               21


<210>  5394
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5394
ctttagtcca ygtgtacaga c                                               21


<210>  5395
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5395
aggtgaaaag ragtaaacct c                                               21


<210>  5396
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5396
atctgctatc ycaggggtac c                                               21


<210>  5397
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5397
acagtaataa rctgtatgaa g                                               21


<210>  5398
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5398
cagaggggct rccagagaaa c                                               21


<210>  5399
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5399
tccgcacaac ytgccctctc c                                               21


<210>  5400
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5400
aggtagtcat ragttcactg c                                               21


<210>  5401
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5401
aagtgcagga rcatgtgtga g                                               21


<210>  5402
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5402
atacaataaa rgaggaagca g                                               21


<210>  5403
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5403
atgtgcttca kacagtctct g                                               21


<210>  5404
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5404
catcctctaa raatcttcat c                                               21


<210>  5405
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5405
acctacttgt rtcttgtggg t                                               21


<210>  5406
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5406
actctgtgat rtgtagttat a                                               21


<210>  5407
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5407
cttttgttgg rggggagaga g                                               21


<210>  5408
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5408
aacctgctgg ragatctagg a                                               21


<210>  5409
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5409
ccttttcttt mcaacagggt c                                               21


<210>  5410
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5410
gtatgacaag yttctaagtt t                                               21


<210>  5411
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5411
ttcatacatt ytcatttgat c                                               21


<210>  5412
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5412
agtgatatta ygtatctttt c                                               21


<210>  5413
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5413
tttatatata ytaactgcag c                                               21


<210>  5414
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5414
gtgtgacacc ratatggcat c                                               21


<210>  5415
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5415
ggggaagtgg kgacattcac t                                               21


<210>  5416
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5416
agcagagatg rgtaaaaggg g                                               21


<210>  5417
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5417
caccaccatc rtgacggctt t                                               21


<210>  5418
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5418
tcctcctaca rctcacagca g                                               21


<210>  5419
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5419
ggctatataa rttttttaag a                                               21


<210>  5420
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5420
accctgagac kgttcattat t                                               21


<210>  5421
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5421
atcatgtcct yaggttgcaa c                                               21


<210>  5422
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5422
ttgtgcccag kaggaaagag a                                               21


<210>  5423
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5423
gcaatttgct rtactggctt t                                               21


<210>  5424
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5424
tcagatggcc ygtcctttgt a                                               21


<210>  5425
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5425
ttgagtttac yttccagctt c                                               21


<210>  5426
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5426
cacattccta ytgtaggctg t                                               21


<210>  5427
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5427
catctctcag ktgtcctaga t                                               21


<210>  5428
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5428
acatgaagga yaagaaggca g                                               21


<210>  5429
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5429
acaatttcct rttgaatccc t                                               21


<210>  5430
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5430
gcttcataga ytgtgcaaca a                                               21


<210>  5431
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5431
acgtaatttc yagcttaaca g                                               21


<210>  5432
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5432
ctatacgaac rtcacttctg a                                               21


<210>  5433
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5433
gtgacctcct ractatcctc t                                               21


<210>  5434
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5434
ggatctgctt raagatcttt a                                               21


<210>  5435
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5435
tacaactaaa yagatcttca a                                               21


<210>  5436
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5436
ttattagcta kgtaaaagct c                                               21


<210>  5437
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5437
aagcaggatg ytgctgctac a                                               21


<210>  5438
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5438
tttagtcaca ytgaattttt g                                               21


<210>  5439
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5439
ctagtacaga yggacacagt t                                               21


<210>  5440
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5440
ttttgatggc ygcctttcaa t                                               21


<210>  5441
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5441
catggcagcc ygaacactgt c                                               21


<210>  5442
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5442
aagcctaaaa yactctgagt a                                               21


<210>  5443
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5443
catatgctca rtaaccacat g                                               21


<210>  5444
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5444
ctaaatagtc rttttttacc t                                               21


<210>  5445
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5445
gaggctccta yggagtctgg a                                               21


<210>  5446
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5446
aaatatttgc yatccataca t                                               21


<210>  5447
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5447
cttacgcatc kggataattc c                                               21


<210>  5448
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5448
cctatagatg ytattaagtt g                                               21


<210>  5449
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5449
aacttggtgg rcaactatgg t                                               21


<210>  5450
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5450
taagcaatgc rtgactgact g                                               21


<210>  5451
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5451
ggggtcaaca kgctgtggcc c                                               21


<210>  5452
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5452
tctctaatat ragtttattc a                                               21


<210>  5453
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5453
atctgtgaag rgaccagcca t                                               21


<210>  5454
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5454
tgtgttagat yttactaatt t                                               21


<210>  5455
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5455
caggaagtta racttcatct a                                               21


<210>  5456
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5456
ggaatgttta ygtttttagt a                                               21


<210>  5457
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5457
gagctttggc rgaaaccaaa g                                               21


<210>  5458
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5458
ttctccttcc mtgtgacagg a                                               21


<210>  5459
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5459
tttcaatgcc rgactaaaag t                                               21


<210>  5460
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5460
attccttatt ytctaatttt a                                               21


<210>  5461
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5461
atactgtcta kccctttttg c                                               21


<210>  5462
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5462
aaaggtttaa ygaaagcaag t                                               21


<210>  5463
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5463
tattaaggca raatttcatg t                                               21


<210>  5464
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5464
gtgctgacca rttgtaaaaa c                                               21


<210>  5465
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5465
tcctctggct yagatagtgg c                                               21


<210>  5466
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5466
ggagatgggc mgcggggtca t                                               21


<210>  5467
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5467
ccagtactag kggagacaag c                                               21


<210>  5468
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5468
gttccccgag ytagggttct c                                               21


<210>  5469
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5469
actcactaac rgtactttaa a                                               21


<210>  5470
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5470
ttagaaagac yacttttaag c                                               21


<210>  5471
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5471
ccttgctaca kccataagta a                                               21


<210>  5472
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5472
tcaccttttt rccaccttca c                                               21


<210>  5473
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5473
ccattaggac ktaattgcct a                                               21


<210>  5474
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5474
tttttgtatt yttatgttcc a                                               21


<210>  5475
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5475
tgatttcctc yggcatcact g                                               21


<210>  5476
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5476
gctttgggta ygtatttttc c                                               21


<210>  5477
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5477
ataattttta kttggcagtt t                                               21


<210>  5478
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5478
attctaaagt mttaaacaat t                                               21


<210>  5479
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5479
taacttcttg rctccaggct c                                               21


<210>  5480
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5480
agtgctctcc yacctctatt c                                               21


<210>  5481
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5481
catcacttcc ragagtttcc t                                               21


<210>  5482
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5482
tttttcacct ytgtgcatgc c                                               21


<210>  5483
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5483
ggatgtttga ygtgttttct t                                               21


<210>  5484
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5484
aagacctgaa ygtctttctg g                                               21


<210>  5485
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5485
gatgtatgtt ktaggcaaag g                                               21


<210>  5486
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5486
taaatttgtg kctgagaaag t                                               21


<210>  5487
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5487
aacagtgctg ytactgaaca t                                               21


<210>  5488
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5488
aaaattatct kggcctcgtg t                                               21


<210>  5489
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5489
tattgtgtca rtttggtaag a                                               21


<210>  5490
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5490
tttatttatg ktgttaaaat t                                               21


<210>  5491
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5491
tcctttaaga yggcccccac g                                               21


<210>  5492
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5492
agatgataaa ygtttgcttt t                                               21


<210>  5493
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5493
attttctgtc rtacaagtca a                                               21


<210>  5494
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5494
ctccttacaa kttaaaatcg g                                               21


<210>  5495
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5495
ataaataaca yggaataaga a                                               21


<210>  5496
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5496
tatccctgtc raaggcctct t                                               21


<210>  5497
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5497
atgccgaggt ygggggtatg g                                               21


<210>  5498
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5498
gaacaaggta ytcatcaaga t                                               21


<210>  5499
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5499
tggcttaaca rttggtctac a                                               21


<210>  5500
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5500
tgatgggttt magggaacac t                                               21


<210>  5501
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5501
ttaggctctc yagttcacgg a                                               21


<210>  5502
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5502
ttatttagtt ytttatgttt t                                               21


<210>  5503
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5503
aacttcattg mgtattgccc t                                               21


<210>  5504
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5504
tgattgctga mtatttcgta a                                               21


<210>  5505
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5505
attcatcttt mggcacttcc t                                               21


<210>  5506
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5506
tattctctcg mgtctcctta t                                               21


<210>  5507
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5507
tgtgacactc rgtagaggta a                                               21


<210>  5508
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5508
tttggtctag ygtcctatag a                                               21


<210>  5509
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5509
gcaagcaaga ygttgcctgt c                                               21


<210>  5510
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5510
gtccttcata raaacaagtg c                                               21


<210>  5511
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5511
tagacatttg yggcaaccac a                                               21


<210>  5512
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5512
ttactactct rgagctaccc a                                               21


<210>  5513
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5513
tgctgcatat ragaagactc a                                               21


<210>  5514
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5514
agtgaacaca rtggtctcag c                                               21


<210>  5515
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5515
ataacctaaa yaagtacagt c                                               21


<210>  5516
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5516
gtttgatact rtgaagtttc c                                               21


<210>  5517
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5517
catgttccag kgtgcactaa c                                               21


<210>  5518
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5518
gtgaatagag yttaaggctt t                                               21


<210>  5519
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5519
atattttcct ktatgccttt t                                               21


<210>  5520
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5520
gttcaaagca rtgtctgggc t                                               21


<210>  5521
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5521
aagaagtgtg ygtagaacag g                                               21


<210>  5522
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5522
gagcacctta rtcaagcata t                                               21


<210>  5523
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5523
ttgtatctca kcagtggaga a                                               21


<210>  5524
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5524
aaagtagaca yagctcccgg t                                               21


<210>  5525
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5525
gctgagtgaa yatgtgagaa t                                               21


<210>  5526
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5526
tgaaacttaa maattgctcc c                                               21


<210>  5527
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5527
aaaggtttct mtttcaacac t                                               21


<210>  5528
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5528
tataaaatca yatcttcaca a                                               21


<210>  5529
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5529
tctgggacca ytggaaaagg g                                               21


<210>  5530
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5530
tggcgtaggt rggtggttct a                                               21


<210>  5531
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5531
tctgggtaaa ygtaaagaaa g                                               21


<210>  5532
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5532
tgctcaaatc rtaagtgagg a                                               21


<210>  5533
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5533
ccacagttgg ygacgctttc a                                               21


<210>  5534
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5534
caaaacaggt mttataatca t                                               21


<210>  5535
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5535
actgattaca ytgtcgcaca g                                               21


<210>  5536
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5536
agatacaagt kcacttattg t                                               21


<210>  5537
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5537
ctaaaatggt rctttgctat a                                               21


<210>  5538
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5538
aagcagagcc kctctacctg a                                               21


<210>  5539
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5539
ctctattatg mcatctcttt t                                               21


<210>  5540
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5540
ttagaagcag rgccaggcct g                                               21


<210>  5541
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5541
cttgtctgtg mtttggaggc t                                               21


<210>  5542
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5542
aggacatagc ygtggctcag c                                               21


<210>  5543
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5543
gatacacttt ytggtatatt t                                               21


<210>  5544
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5544
acatgatgta ycacataaaa a                                               21


<210>  5545
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5545
ctttcacagg ktagttattg t                                               21


<210>  5546
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5546
taactttccc yggcgtatag g                                               21


<210>  5547
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5547
gaacataggc ytctaatccc a                                               21


<210>  5548
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5548
tgaaaacatt rgccataact g                                               21


<210>  5549
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5549
gatgccaaca mccaaagatg g                                               21


<210>  5550
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5550
tcccatttgc rgaccttcag a                                               21


<210>  5551
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5551
cagatggttc rgctaataga g                                               21


<210>  5552
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5552
gcagcaaaat rtcttaatgg t                                               21


<210>  5553
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5553
agactgtgct rgaaactcag t                                               21


<210>  5554
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5554
gaccagagta yatttgactc c                                               21


<210>  5555
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5555
tgcacctcac rgtttcttct g                                               21


<210>  5556
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5556
aggttataag raaggtgcag a                                               21


<210>  5557
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5557
ttctcatgca ytctccacct t                                               21


<210>  5558
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5558
gcaccaagaa rgctaagtaa t                                               21


<210>  5559
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5559
gaaagatgcc raagatcggt a                                               21


<210>  5560
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5560
atctgcatat rtggagcact t                                               21


<210>  5561
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5561
tatacactga rttttccagg g                                               21


<210>  5562
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5562
caccaaattc rgaaacactt t                                               21


<210>  5563
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5563
cttttctgtt rtcttcttca t                                               21


<210>  5564
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5564
gagagacagg magtgaagag c                                               21


<210>  5565
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5565
gctccataga racacaaggt a                                               21


<210>  5566
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5566
atgtcatgac mcttggtctg t                                               21


<210>  5567
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5567
tttcttagtc ygaagcaatg a                                               21


<210>  5568
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5568
tgtgaccaga rgaatgcaga g                                               21


<210>  5569
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5569
gttctccata maagattacc t                                               21


<210>  5570
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5570
aagacaaaaa ygtaaggtgg c                                               21


<210>  5571
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5571
tttaataata rcccacgact c                                               21


<210>  5572
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5572
cggcaacttc ragggaatac t                                               21


<210>  5573
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5573
tatacaatat rccttgatat c                                               21


<210>  5574
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5574
gacacacata yacaaaaaaa c                                               21


<210>  5575
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5575
tagggtgtga rgattgtggt t                                               21


<210>  5576
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5576
acacgactac rtaaaattct a                                               21


<210>  5577
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5577
agtctgtatc ytcatcctac c                                               21


<210>  5578
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5578
tgagacatgc racctgtgaa c                                               21


<210>  5579
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5579
ccacagagca maaacctgtc c                                               21


<210>  5580
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5580
ctgtctctcc rtgcctagca a                                               21


<210>  5581
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5581
ggcctttctc rttggtcctc a                                               21


<210>  5582
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5582
gagctgaacc rtgatttctc t                                               21


<210>  5583
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5583
atgacttcac ycacctgctt t                                               21


<210>  5584
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5584
gtctagttct rtgttcctgc a                                               21


<210>  5585
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5585
gctactaaga ygttgtttag g                                               21


<210>  5586
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5586
caaaatcaaa ygaccaatcc c                                               21


<210>  5587
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5587
caaagccgta yatcaccaca t                                               21


<210>  5588
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5588
cacttcaagg rccacaagaa a                                               21


<210>  5589
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5589
gaaaggaatc rtagccctgt g                                               21


<210>  5590
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5590
gtctagcttt yttgttgtat t                                               21


<210>  5591
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5591
ggaaggataa ygtgagtaga g                                               21


<210>  5592
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5592
tgaattaaca rcgataccta t                                               21


<210>  5593
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5593
cttgttatgt rtgttactga a                                               21


<210>  5594
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5594
taagatgtct rgatttttta a                                               21


<210>  5595
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5595
tgaatttaaa ragaatggac a                                               21


<210>  5596
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5596
caactgttaa rtagaatccc t                                               21


<210>  5597
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5597
gggtagagga ytgatgggga a                                               21


<210>  5598
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5598
tcatgtcctg rgttggttgg g                                               21


<210>  5599
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5599
tgtatgtgtg ytttcctcca g                                               21


<210>  5600
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5600
tcagtggtta mtgggataaa c                                               21


<210>  5601
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5601
tattttccca ygttttcaca t                                               21


<210>  5602
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5602
acaacgattg yggtttcagt t                                               21


<210>  5603
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5603
tatggcacat rcatgccaca g                                               21


<210>  5604
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5604
tgcccttgca yaggcaccct c                                               21


<210>  5605
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5605
atttgaagaa racaataaaa t                                               21


<210>  5606
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5606
cattgctttc ktattgattt g                                               21


<210>  5607
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5607
tatattgttt yctattttcc c                                               21


<210>  5608
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5608
aaaacatctt mtggttaaag c                                               21


<210>  5609
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5609
accattatta yagtattaga a                                               21


<210>  5610
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5610
tcaagctgca yttaattcat t                                               21


<210>  5611
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5611
gcattaaaac maactaatac g                                               21


<210>  5612
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5612
actcaatgct raaattaaaa a                                               21


<210>  5613
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5613
ctatacgtga maagtaaagt a                                               21


<210>  5614
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5614
ttttaaaaat ktgacatctt t                                               21


<210>  5615
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5615
cacaccagag raaacaaggt g                                               21


<210>  5616
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5616
caataatttt rtgacttcag t                                               21


<210>  5617
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5617
tagtgtaatg kgataaacca c                                               21


<210>  5618
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5618
catggacata ytgctgtgct c                                               21


<210>  5619
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5619
tatttacaaa raactaacca g                                               21


<210>  5620
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5620
agaatatggc macgactcgt c                                               21


<210>  5621
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5621
ccaaagcagc ygcaaaattt t                                               21


<210>  5622
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5622
tattagaaga mgataccatc t                                               21


<210>  5623
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5623
acggctgcat rtcaataact a                                               21


<210>  5624
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5624
tttgaaaaag ktctaccacc a                                               21


<210>  5625
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5625
gccccggata rttaactttt g                                               21


<210>  5626
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5626
ttcctctcta ygactgaata t                                               21


<210>  5627
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5627
ggactttatc rcttgcacct t                                               21


<210>  5628
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5628
gctcattgct kgtatcgatt t                                               21


<210>  5629
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5629
tttgaagagt rtaaggggct t                                               21


<210>  5630
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5630
actacagcta ycatgttgta c                                               21


<210>  5631
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5631
gcctgcagat rgatgtcttt c                                               21


<210>  5632
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5632
ctaccttgca rtgaagaggc t                                               21


<210>  5633
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5633
cagcatttgc rtctatctct t                                               21


<210>  5634
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5634
tgattattac ytccccatca g                                               21


<210>  5635
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5635
accctcccat rtattcagtt g                                               21


<210>  5636
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5636
ttagatctgt raaggggaat g                                               21


<210>  5637
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5637
gtagatttca rtcaagagta g                                               21


<210>  5638
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5638
agggtaaaca kgaaagcgtg a                                               21


<210>  5639
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5639
ctttctttaa rgttcttcct g                                               21


<210>  5640
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5640
gcttcaggaa rttttattgt a                                               21


<210>  5641
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5641
atctttatgg rgaaaattat a                                               21


<210>  5642
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5642
caagctgata ytaaagctga a                                               21


<210>  5643
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5643
tgctttctct rccccttgct g                                               21


<210>  5644
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5644
aaagtctccc ratgggtccc t                                               21


<210>  5645
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5645
tcataatgat yaccagatta t                                               21


<210>  5646
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5646
taatcttttc rcctcggaat t                                               21


<210>  5647
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5647
ctactggtga yaaagtataa g                                               21


<210>  5648
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5648
ggtggaatcc rtagagtaat g                                               21


<210>  5649
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5649
ctttcccaac raggaggtag a                                               21


<210>  5650
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5650
agggcatacc yattcagagg t                                               21


<210>  5651
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5651
aagactcttt rgctttggta g                                               21


<210>  5652
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5652
tgtaacacaa ygaatgagat g                                               21


<210>  5653
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5653
gaatctctac rctttttaaa t                                               21


<210>  5654
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5654
aaggaaagga kgaatctatg g                                               21


<210>  5655
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5655
aacatgagtg yatagataga t                                               21


<210>  5656
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5656
tgaaatattc rtacaatgcg t                                               21


<210>  5657
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5657
gggagcccag rcttgacaga g                                               21


<210>  5658
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5658
agattgccca ytattaagat t                                               21


<210>  5659
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5659
taaaatggtc rataaccaaa a                                               21


<210>  5660
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5660
aagctaatct rtaaattgga g                                               21


<210>  5661
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5661
gcagcacaca ytgatttctc c                                               21


<210>  5662
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5662
aactaggaac yagtgctctc a                                               21


<210>  5663
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5663
agatgcaggg katcccagca g                                               21


<210>  5664
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5664
ttcactatta ytgacaaaca t                                               21


<210>  5665
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5665
catcctttca ygataaagag a                                               21


<210>  5666
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5666
gatatagagc rttctgaaag g                                               21


<210>  5667
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5667
cacttatact rccagctaca g                                               21


<210>  5668
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5668
tcagtctcca kggtcagcaa t                                               21


<210>  5669
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5669
gacaataaac rtaagtcaaa c                                               21


<210>  5670
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5670
agtcaaactt yttgcagcct a                                               21


<210>  5671
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5671
gaagtcagca yaacatgggg t                                               21


<210>  5672
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5672
caattatata ytcctccggg t                                               21


<210>  5673
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5673
cccttgacca rtagctcccc a                                               21


<210>  5674
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5674
ttgtggcata kctagagttt t                                               21


<210>  5675
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5675
ttctcgctcc rtctaaatca c                                               21


<210>  5676
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5676
aaaactaatt ygttcactga a                                               21


<210>  5677
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5677
tgctacgatt ygaccctatt t                                               21


<210>  5678
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5678
aagtagactt mtaaaccact g                                               21


<210>  5679
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5679
cctacctgac rtctgacact a                                               21


<210>  5680
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5680
tagggtatat matttaaggg a                                               21


<210>  5681
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5681
ctatgactat rtctacatat c                                               21


<210>  5682
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5682
aataggtata yctgtaaggt c                                               21


<210>  5683
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5683
ttacacactc ytagccaata a                                               21


<210>  5684
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5684
gtcactaccc rccttgataa t                                               21


<210>  5685
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5685
atgaaacatg mcacttaaac a                                               21


<210>  5686
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5686
catggaagga yatttatcta a                                               21


<210>  5687
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5687
agaattgaac yaattataat c                                               21


<210>  5688
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5688
ggtgctattt rtatggaggt t                                               21


<210>  5689
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5689
atgatcagag rgaaggaaag t                                               21


<210>  5690
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5690
ccattttctg ytaccacata t                                               21


<210>  5691
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5691
agctcctgag ytggggacct c                                               21


<210>  5692
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5692
ttctctgccc ytgcctgcac c                                               21


<210>  5693
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5693
tgcatttcag rgtaaacagt t                                               21


<210>  5694
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5694
acttccagcc raactggttg t                                               21


<210>  5695
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5695
ttctataaca rtttggcttc t                                               21


<210>  5696
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5696
cagacctctt rtgtgttgca c                                               21


<210>  5697
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5697
gccgatttct ycaatacaca c                                               21


<210>  5698
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5698
cctcctcccc rcaaaggaga a                                               21


<210>  5699
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5699
ttcaagaacc kgccagcctt t                                               21


<210>  5700
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5700
ggaatcaaca mcacctcact t                                               21


<210>  5701
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5701
ttggcactcc raggcctgga t                                               21


<210>  5702
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5702
aaaattgaag yctaaaagct t                                               21


<210>  5703
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5703
cctaagttga rataaattgt g                                               21


<210>  5704
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5704
ctctcttaac ygaaataaga g                                               21


<210>  5705
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5705
cataaccaga yaacctgtcc a                                               21


<210>  5706
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5706
gatgagtgca macatccttc c                                               21


<210>  5707
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5707
aaaatgaccc ycctcagcct t                                               21


<210>  5708
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5708
tgaggaaagc rtttcagaga g                                               21


<210>  5709
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5709
ttgtttagga ygatagtttt a                                               21


<210>  5710
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5710
tgctaatgac rcagacaaat g                                               21


<210>  5711
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5711
gggaaaatat kcaaaggtcc t                                               21


<210>  5712
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5712
tccctcccag yatgaaaaaa g                                               21


<210>  5713
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5713
atatttgatg maaagtgaga c                                               21


<210>  5714
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5714
gcctcccagc ratgtgtgta c                                               21


<210>  5715
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5715
ggtcctaggc yacctttccc g                                               21


<210>  5716
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5716
atagacaaac rggtgttggc t                                               21


<210>  5717
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5717
tttctggcag kactctagca t                                               21


<210>  5718
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5718
agtctcccca rgcctcaggc a                                               21


<210>  5719
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5719
cttaagggat rgtgggcgtg t                                               21


<210>  5720
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5720
caaagtttgt ytttcatctc a                                               21


<210>  5721
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5721
aagactaaac rttaaaatgt g                                               21


<210>  5722
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5722
atacaaaaat mtaaagtcca g                                               21


<210>  5723
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5723
tcatacatat raataaaaag g                                               21


<210>  5724
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5724
tgccactgat kgactacaaa a                                               21


<210>  5725
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5725
ttagtcacct kgccatcagc c                                               21


<210>  5726
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5726
ctaacagaaa rgctggcttc c                                               21


<210>  5727
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5727
caaactgtat yatctgtcac a                                               21


<210>  5728
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5728
tacctttaaa rgagggtatt a                                               21


<210>  5729
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5729
tacaatattt ktccatgtcc c                                               21


<210>  5730
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5730
aaacaaagca yagctagata a                                               21


<210>  5731
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5731
aaagacattc ytacttgatt a                                               21


<210>  5732
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5732
aggtttggaa yagagagggg g                                               21


<210>  5733
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5733
ctatgcacac ytgaaattat a                                               21


<210>  5734
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5734
ttctttcacc rtcaagaatg t                                               21


<210>  5735
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5735
gtgttactgt rcaattattg g                                               21


<210>  5736
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5736
agactcaggc ygaagtctcc a                                               21


<210>  5737
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5737
gagtctcgtt ycaccaccga a                                               21


<210>  5738
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5738
atgtgtccag kttaggaaaa t                                               21


<210>  5739
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5739
caaaagcaag rgctaataca a                                               21


<210>  5740
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5740
agaacagatc ycaggttagg a                                               21


<210>  5741
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5741
ttaaggaaat rgaattgatt t                                               21


<210>  5742
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5742
aatcccctcc rtgatcagcc t                                               21


<210>  5743
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5743
atggccaggc yatgctcttt c                                               21


<210>  5744
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5744
tatggtgtga ygctgaggtt t                                               21


<210>  5745
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5745
acaggggtgt rgggaagctc t                                               21


<210>  5746
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5746
gaaaaggggg ktgtttaaag t                                               21


<210>  5747
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5747
ttaactttac ygctgtcttg g                                               21


<210>  5748
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5748
gagtaactcc rtttggccga t                                               21


<210>  5749
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5749
attagaaaac ytgagtggcc t                                               21


<210>  5750
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5750
cccgtgcttt rtgacatctg c                                               21


<210>  5751
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5751
ctttgatcag rgaatggtat g                                               21


<210>  5752
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5752
cctccgatat ktgggggcag a                                               21


<210>  5753
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5753
ccagtttcct rtgccatgct g                                               21


<210>  5754
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5754
aaccaatctc ytgtttttgg c                                               21


<210>  5755
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5755
gttatgacga yttaactttg g                                               21


<210>  5756
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5756
ctggctgtca yggccctggg c                                               21


<210>  5757
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5757
ggtgacgtac rtggacgcac t                                               21


<210>  5758
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5758
tggtggagag raatgggaca c                                               21


<210>  5759
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5759
cccaggcacc ktggcttctc t                                               21


<210>  5760
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5760
tttccagttt ygagaggcca c                                               21


<210>  5761
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5761
caaaaaacaa rcaaaactct c                                               21


<210>  5762
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5762
tcagggggct kcagtggtct g                                               21


<210>  5763
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5763
acagtagtac rtgcttcaag a                                               21


<210>  5764
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5764
tcaccactgg ycctgataac a                                               21


<210>  5765
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5765
gccctcttgt ytctggcttt t                                               21


<210>  5766
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5766
agataccaat rtctcagtga g                                               21


<210>  5767
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5767
ttcctgcttg mccctgctca g                                               21


<210>  5768
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5768
tggtgaggca rgctttcaag t                                               21


<210>  5769
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5769
ttcccttggg ktttctctcc c                                               21


<210>  5770
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5770
cctcatgacc mcttattagt a                                               21


<210>  5771
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5771
aaatgttcct rgaggtcttc t                                               21


<210>  5772
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5772
tttctcaaca yggtttttac a                                               21


<210>  5773
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5773
ccttcttacc rgaaccttgt g                                               21


<210>  5774
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5774
cttgtttagt ycttcattca g                                               21


<210>  5775
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5775
ggcctgggcc rctggatagc t                                               21


<210>  5776
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5776
gctctgtgaa rcatgttcac a                                               21


<210>  5777
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5777
tgagtagaac ygggccagtt g                                               21


<210>  5778
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5778
gctcagtgac rtcaacagga t                                               21


<210>  5779
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5779
ctggaaggtc rggaaatcca g                                               21


<210>  5780
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5780
tatctcatgg kgaaaagtga a                                               21


<210>  5781
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5781
tagggaactt rgggcccagt c                                               21


<210>  5782
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5782
tgaaattggc ygaaaagaca t                                               21


<210>  5783
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5783
actgggcatc yggagagagg g                                               21


<210>  5784
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5784
agtatagaaa ycagaatata t                                               21


<210>  5785
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5785
tgattttcct yaacctcctt c                                               21


<210>  5786
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5786
cctgccacct ygctcttgtt t                                               21


<210>  5787
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5787
ttttgttgac ytaattacct c                                               21


<210>  5788
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5788
tgtcactcat rgatgaatca c                                               21


<210>  5789
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5789
tttattcaca ycttgacaaa t                                               21


<210>  5790
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5790
ccaaaccacc rgtccagaaa t                                               21


<210>  5791
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5791
cccatgagtt rtaaattttt t                                               21


<210>  5792
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5792
tctttataac ygcataatca g                                               21


<210>  5793
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5793
aaaaatgggc raatatttga a                                               21


<210>  5794
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5794
atttttcata ygagttgaat c                                               21


<210>  5795
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5795
tgttatccca ytcccttatg g                                               21


<210>  5796
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5796
tgagacagac rttttctggg t                                               21


<210>  5797
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5797
tatgtctctt ytttggtgac t                                               21


<210>  5798
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5798
atatgaattg ragtcacaaa g                                               21


<210>  5799
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5799
tctatggtga kgtgcagtca a                                               21


<210>  5800
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5800
gggcactctt rtcctggcat t                                               21


<210>  5801
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5801
tagaaatctt yctttaagtc c                                               21


<210>  5802
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5802
cttggctact ygagcccaaa a                                               21


<210>  5803
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5803
cacatttttg ytctagggcc c                                               21


<210>  5804
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5804
ttgggcccca ytctctgagt a                                               21


<210>  5805
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5805
tttttaacat ygttttcttc a                                               21


<210>  5806
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5806
ctgtcaaatc ygtctgccct t                                               21


<210>  5807
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5807
aaataggcca ygtccaggta g                                               21


<210>  5808
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5808
atcttttgtc rtcagcacat t                                               21


<210>  5809
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5809
gtaaaattca ycatcacaaa c                                               21


<210>  5810
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5810
ttattatttc yatccagtaa t                                               21


<210>  5811
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5811
ataaatttca rtagtataag t                                               21


<210>  5812
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5812
tgcaactcac rtaaaggtcc a                                               21


<210>  5813
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5813
cacatttcca yaataagaca a                                               21


<210>  5814
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5814
tggcaaattc rggacctgcc a                                               21


<210>  5815
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5815
taccacgaat ygagatggag a                                               21


<210>  5816
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5816
cattgaagcc rcagggctcc a                                               21


<210>  5817
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5817
acatgttact rtttggtcag c                                               21


<210>  5818
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5818
acctgccacc rttgaacttg t                                               21


<210>  5819
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5819
ctagagacta ycaactgctc a                                               21


<210>  5820
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5820
caaatatcac rcttaagtca t                                               21


<210>  5821
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5821
caccctcatt rgaaggaagg c                                               21


<210>  5822
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5822
gaaagaagag yttttgttcg c                                               21


<210>  5823
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5823
ccttctggtc yagaggccca g                                               21


<210>  5824
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5824
taactacccc ratcatcaca c                                               21


<210>  5825
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5825
cacaaacaca ygccaacatg t                                               21


<210>  5826
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5826
acaggctgcc rgccccagct c                                               21


<210>  5827
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5827
tacaaactgg rcaaagacat t                                               21


<210>  5828
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5828
tattccatta rggcactgac t                                               21


<210>  5829
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5829
tagcaaattt raaaaggctt c                                               21


<210>  5830
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5830
accaacttcc yggagtatga t                                               21


<210>  5831
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5831
actagaccaa yaaatctaaa t                                               21


<210>  5832
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5832
ttgaaacata ytaatatgag g                                               21


<210>  5833
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5833
aagttgtagc ygtaagacag g                                               21


<210>  5834
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5834
aattaatacc rtttcttcac c                                               21


<210>  5835
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5835
cgcttacaga maatagcagg c                                               21


<210>  5836
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5836
tgttgtagta rtgagccctt t                                               21


<210>  5837
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5837
ctttgggaga yttttttgag c                                               21


<210>  5838
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5838
gatggaggag rcacccgaag c                                               21


<210>  5839
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5839
acagatgaat rcactttatg a                                               21


<210>  5840
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5840
agacacaata yactgtaagt c                                               21


<210>  5841
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5841
aaaacattcc rcagaggaac g                                               21


<210>  5842
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5842
gcatccagat raaacctaaa g                                               21


<210>  5843
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5843
ttgcaatcct yctttagagt t                                               21


<210>  5844
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5844
gggtcacacg rcctacggct a                                               21


<210>  5845
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5845
tcctgagaaa kaaaaaagtt t                                               21


<210>  5846
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5846
tcagagcggg rgaaaaaaag a                                               21


<210>  5847
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5847
ctctgccttg rtcctcactt c                                               21


<210>  5848
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5848
tattctcgaa rccaatttta c                                               21


<210>  5849
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5849
ctgcttttgg yatcagagta a                                               21


<210>  5850
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5850
gaatggtcta magaaaggta c                                               21


<210>  5851
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5851
cactatgtga ytcaatgaca t                                               21


<210>  5852
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5852
gtttctgtta ygtctttgaa a                                               21


<210>  5853
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5853
tgcagttaaa yagacaggct c                                               21


<210>  5854
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5854
ataatcaatt yggggaaaca a                                               21


<210>  5855
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5855
tcaactaacc yaatttcaat a                                               21


<210>  5856
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5856
cttgaaaacc rtatgctaat t                                               21


<210>  5857
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5857
taaggaatga raggaaaatc c                                               21


<210>  5858
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5858
aagacagcca ktacagtact t                                               21


<210>  5859
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5859
agcagacaat yagaaccact c                                               21


<210>  5860
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5860
gtcattcaaa kggttccatg t                                               21


<210>  5861
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5861
aacaaaacac rcacactcaa g                                               21


<210>  5862
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5862
aatacaaaac yacaatgatt a                                               21


<210>  5863
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5863
ctacttccat ragccctttc c                                               21


<210>  5864
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5864
ccagtcaatc rccatgctac c                                               21


<210>  5865
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5865
ggctagatac rggtaaatgc a                                               21


<210>  5866
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5866
aagctctaac yggtccagct t                                               21


<210>  5867
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5867
caaataaaag katgaatgat t                                               21


<210>  5868
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5868
ttgtaatctg rccttttgaa a                                               21


<210>  5869
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5869
gagactagag rgagagctgg a                                               21


<210>  5870
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5870
tgttctttct rtacaatgac t                                               21


<210>  5871
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5871
taaagatgtt raagtagaga t                                               21


<210>  5872
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5872
cacctggtga maagttgatt a                                               21


<210>  5873
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5873
gagttttcca ygaaatagac a                                               21


<210>  5874
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5874
gtgagagatg kggtctatat t                                               21


<210>  5875
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5875
aacaagccac rtatcttgaa g                                               21


<210>  5876
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5876
gaggcaaatt rcacagcttt a                                               21


<210>  5877
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5877
tcccctggca ytgctgttac a                                               21


<210>  5878
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5878
gcaaaattga ygggcttcag t                                               21


<210>  5879
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5879
cctccgtgta yctccccgtg a                                               21


<210>  5880
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5880
tgactgcaca ratagtcaac a                                               21


<210>  5881
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5881
ctacttgggg rcaggaaaat g                                               21


<210>  5882
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5882
ttgggattgt ygaggccaat g                                               21


<210>  5883
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5883
agcgcgggac ytcgtattct g                                               21


<210>  5884
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5884
cacatagaca ygcaatagag c                                               21


<210>  5885
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5885
ccaagggaag rggagaagct g                                               21


<210>  5886
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5886
tgtggtcatc rgaattccct t                                               21


<210>  5887
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5887
gatggcagct ktggaacaag a                                               21


<210>  5888
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5888
tccgcagcac rccctctctt a                                               21


<210>  5889
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5889
ttctcaacac rgcactctag g                                               21


<210>  5890
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5890
ccatgacatg rcccagcctc a                                               21


<210>  5891
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5891
gttcaattct yacctccccg g                                               21


<210>  5892
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5892
ccagtgtcct rtttgtgtcc c                                               21


<210>  5893
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5893
caccggtaga rcctgcagtc a                                               21


<210>  5894
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5894
ttaggccatt ygtgtgttgc t                                               21


<210>  5895
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5895
accctcaagc rtttggggaa g                                               21


<210>  5896
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5896
gagatctcac ytaaactaag a                                               21


<210>  5897
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5897
ccccatagca rtttgttgca c                                               21


<210>  5898
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5898
gttcaacttc rtattctttg a                                               21


<210>  5899
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5899
aagctagtga racaggaaaa g                                               21


<210>  5900
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5900
agttcctcca ygaataatgt a                                               21


<210>  5901
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5901
caactagtca rtctttaaca c                                               21


<210>  5902
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5902
tacatgttta yttttctgat g                                               21


<210>  5903
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5903
tttttgctgt rttgtaggtt c                                               21


<210>  5904
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5904
ctaacaattc ygtagtggtt g                                               21


<210>  5905
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5905
cgaaagtgct yggtgagcct g                                               21


<210>  5906
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5906
aaaaggaaaa maagtagaaa t                                               21


<210>  5907
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5907
tgctcacggt yaccaaggtt t                                               21


<210>  5908
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5908
ctaactagac rtcccagaaa c                                               21


<210>  5909
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5909
gcacagactt ycctggccta a                                               21


<210>  5910
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5910
acattcaccc raaccaggtg a                                               21


<210>  5911
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5911
tcttgagtcc matagagagc t                                               21


<210>  5912
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5912
agggcagaga rgccaagtct c                                               21


<210>  5913
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5913
gctgagttca rcctaacaca g                                               21


<210>  5914
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5914
aattggtgct matctctggg g                                               21


<210>  5915
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5915
atggtacaac rcacaacaca g                                               21


<210>  5916
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5916
ttaaatgcaa yaatatttta g                                               21


<210>  5917
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5917
gtgcttctct rtagtgatca a                                               21


<210>  5918
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5918
actgcttggt ktgggtgccc a                                               21


<210>  5919
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5919
agaaagcggg raggacttga t                                               21


<210>  5920
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5920
cctctgttcc rgcaggaaga t                                               21


<210>  5921
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5921
cacaggatct rgatcgactg a                                               21


<210>  5922
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5922
ttctcttaag rtgtaaacag a                                               21


<210>  5923
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5923
aggtgtccaa yttgtgtccc t                                               21


<210>  5924
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5924
gttcccagtg yccagcctag g                                               21


<210>  5925
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5925
tcatgaggct ycaagattat t                                               21


<210>  5926
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5926
gagccagggc rttgaatgcc a                                               21


<210>  5927
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5927
gtttgttctg rtgtatggta t                                               21


<210>  5928
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5928
tcaggtacca ycagtgaata g                                               21


<210>  5929
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5929
taaagttgcc rcaaacactg a                                               21


<210>  5930
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5930
tgcttatgtg rgaaagagat t                                               21


<210>  5931
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5931
acaaccagca mctcaggttc a                                               21


<210>  5932
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5932
actggttaca rgtatgtatt t                                               21


<210>  5933
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5933
tggttctttc ygactccatt t                                               21


<210>  5934
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5934
tgcaaactac mttattctga a                                               21


<210>  5935
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5935
acagccctca kgggttccag a                                               21


<210>  5936
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5936
ttttaactac yttattccat c                                               21


<210>  5937
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5937
tttgtctttc yaagcttcat t                                               21


<210>  5938
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5938
aaattccctc rgagaaaatt c                                               21


<210>  5939
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5939
aagaccaagg yggctggttc a                                               21


<210>  5940
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5940
agggggccca rttaccatac c                                               21


<210>  5941
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5941
ttgcccatga ygtggaagtc g                                               21


<210>  5942
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5942
gtttctcttt kggattatgc c                                               21


<210>  5943
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5943
atgaagaaca yatgaatctg a                                               21


<210>  5944
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5944
gtgtcaggct ragaaggatg g                                               21


<210>  5945
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5945
tttctgataa ragaccaccg a                                               21


<210>  5946
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5946
actatactcc ycttaaggag t                                               21


<210>  5947
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5947
atctggccca ratgactcag t                                               21


<210>  5948
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5948
gaaaattctt yacacttcac t                                               21


<210>  5949
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5949
agcataatgt rgtaaaataa t                                               21


<210>  5950
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5950
cagtcaacag kgtctgccat g                                               21


<210>  5951
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5951
tcaacagggt ytgccatgtg c                                               21


<210>  5952
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5952
cattcttccc rggtgcagct c                                               21


<210>  5953
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5953
atgacctgag ygggcctgaa t                                               21


<210>  5954
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5954
gagcctataa rgtcttccat a                                               21


<210>  5955
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5955
acaaacttta ytgagcacct a                                               21


<210>  5956
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5956
gaggagctcc rtgatcaagg t                                               21


<210>  5957
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5957
ggtagactta yatgatgcat g                                               21


<210>  5958
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5958
acgtcaacta kggcaccctt t                                               21


<210>  5959
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5959
cttggtttcc rcatctgcag t                                               21


<210>  5960
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5960
agcctttaaa mtagtcatag g                                               21


<210>  5961
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5961
aacttaccct ragatattgt c                                               21


<210>  5962
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5962
gcatcttgga ytgtgtgact c                                               21


<210>  5963
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5963
cctgctgaca kagaatcccc a                                               21


<210>  5964
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5964
aaagcagctc raaggcacag t                                               21


<210>  5965
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5965
ctcttctgat yctgggaaga c                                               21


<210>  5966
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5966
actcccctga yaggcaggca g                                               21


<210>  5967
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5967
tgcagaaggg rcgctggcat g                                               21


<210>  5968
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5968
ctcttccacc rttcagatgc t                                               21


<210>  5969
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5969
attttccatc ktgcaattta t                                               21


<210>  5970
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5970
agagaagatg rgaaagacgg c                                               21


<210>  5971
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5971
ggcccagtcc rcccattagg a                                               21


<210>  5972
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5972
tggatttctc rcttgtgtgg c                                               21


<210>  5973
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5973
tctacttcac rgaagattta g                                               21


<210>  5974
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5974
ataaagttcg ygacagtaaa a                                               21


<210>  5975
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5975
ggctagtttc ytcctttctg g                                               21


<210>  5976
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5976
ggtatataca ytgggtacac a                                               21


<210>  5977
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5977
ttatggacac rcagcaggtg g                                               21


<210>  5978
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5978
gctggaattg maggagatat t                                               21


<210>  5979
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5979
aaccttccta yacttaattc t                                               21


<210>  5980
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5980
gccacaatca mtccgtgttc c                                               21


<210>  5981
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5981
gtactgctta ygcatcagaa a                                               21


<210>  5982
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5982
cagccatcgc raggcccgta a                                               21


<210>  5983
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5983
ttagtttagg yaatatacat a                                               21


<210>  5984
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5984
tcactttgtt mgtatcacaa c                                               21


<210>  5985
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5985
gagaattctt ycacatggct a                                               21


<210>  5986
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5986
aatgacatct rttgaggaag a                                               21


<210>  5987
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5987
cccagatgac ytgaaatgta t                                               21


<210>  5988
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5988
agtagggaaa rggagaaata c                                               21


<210>  5989
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5989
aattctattc rtgatccatt t                                               21


<210>  5990
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5990
gctattctat kaccaggtca a                                               21


<210>  5991
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5991
tctactacag yactgaaaaa t                                               21


<210>  5992
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5992
agaatggtga rtgtcctctt a                                               21


<210>  5993
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5993
gatgaggacc mgtgtatgca g                                               21


<210>  5994
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5994
aatggagcat mtccgcagtc t                                               21


<210>  5995
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5995
tggcaggtag raggggacct c                                               21


<210>  5996
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5996
tgataatacc rgatctcaaa a                                               21


<210>  5997
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5997
gctttcaggg ytgaggccac t                                               21


<210>  5998
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5998
taagcagaat yaatggagtc a                                               21


<210>  5999
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  5999
ctccacagtt ycatgtggct g                                               21


<210>  6000
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6000
aatgagaaaa yggatggaaa a                                               21


<210>  6001
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6001
acatgatgtc rggattcttg a                                               21


<210>  6002
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6002
aaggaagtca ycatggttgt a                                               21


<210>  6003
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6003
attctcacct ytccctgtca c                                               21


<210>  6004
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6004
ttgccattta raggaagtgc a                                               21


<210>  6005
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6005
ccttcaagag ycttctgcct g                                               21


<210>  6006
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6006
tatcacagtc rtgtttttct a                                               21


<210>  6007
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6007
ttgccttgca yggaggtgga g                                               21


<210>  6008
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6008
ttactactga ytgaatgtag c                                               21


<210>  6009
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6009
aaaaacccct ktctttcatg c                                               21


<210>  6010
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6010
ggagccacct kcggccacta a                                               21


<210>  6011
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6011
ggcagcctgc rtgagaagga g                                               21


<210>  6012
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6012
ttcctctttc ytatgtcaaa g                                               21


<210>  6013
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6013
ctgcctcaca ytgggcctca g                                               21


<210>  6014
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6014
gactgatgga ragggtggtg g                                               21


<210>  6015
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6015
gcacattttc maattcatcc a                                               21


<210>  6016
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6016
gactcaaaga yggtttgtgc g                                               21


<210>  6017
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6017
gactgattgg rtgtgccagt t                                               21


<210>  6018
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6018
gcctagggta yttgtcacaa a                                               21


<210>  6019
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6019
ccaggccaga ygggaaaggg a                                               21


<210>  6020
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6020
tgcccaggcc rggagaatgc t                                               21


<210>  6021
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6021
gaatcagcca ygtctttacc a                                               21


<210>  6022
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6022
caagaagtgg ygatcatcgt a                                               21


<210>  6023
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6023
tttcagaggg kttacttctg g                                               21


<210>  6024
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6024
caggagaccc rggagcaccc c                                               21


<210>  6025
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6025
caccctttaa yccctcagtc c                                               21


<210>  6026
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6026
cctagcacct rgaatagtac c                                               21


<210>  6027
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6027
agggcagacc rcgtctagtc c                                               21


<210>  6028
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6028
tcagaatcca ygctctcaac c                                               21


<210>  6029
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6029
cagaagccac ratggagacc c                                               21


<210>  6030
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6030
ggatttggcc yggttttttc t                                               21


<210>  6031
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6031
agggagtggc yttgatcttg g                                               21


<210>  6032
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6032
atttcttgta rtgtcttgca c                                               21


<210>  6033
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6033
actgaaagaa rttggggaca g                                               21


<210>  6034
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6034
ctgcacagtg yttttcttgg g                                               21


<210>  6035
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6035
gtcactggca yagccgccat c                                               21


<210>  6036
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6036
cggaagaggt yaagggtcac t                                               21


<210>  6037
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6037
attgggaatg ygcaggcctg t                                               21


<210>  6038
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6038
ttgctatcat mggtaattct g                                               21


<210>  6039
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6039
acacagcccc ygtcctcaag g                                               21


<210>  6040
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6040
tactagaatt mctggccaag a                                               21


<210>  6041
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6041
cttgatacaa mttagtgttt t                                               21


<210>  6042
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6042
gaaaattctt yactgttgac a                                               21


<210>  6043
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6043
agaatcgcaa yatcagaact t                                               21


<210>  6044
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6044
tcccttagcc rgtttctttc t                                               21


<210>  6045
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6045
gccataatag ygggttgagt c                                               21


<210>  6046
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6046
atgaaaacaa rtgttccaga g                                               21


<210>  6047
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6047
agccaggggc yatcttggca a                                               21


<210>  6048
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6048
cgagggtttt rcaggtgccc a                                               21


<210>  6049
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6049
tggttgcttc rtttcagaat t                                               21


<210>  6050
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6050
ttgagaatga rcgtgattag t                                               21


<210>  6051
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6051
ccacacctgg yggtgctttg t                                               21


<210>  6052
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6052
tctcagaaca yggttttatt c                                               21


<210>  6053
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6053
ttacctgtct kaggtcatgc a                                               21


<210>  6054
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6054
tctcccggtg ycctggaggc t                                               21


<210>  6055
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6055
tggttaagtt kgtgtctgcc c                                               21


<210>  6056
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6056
ggctcagagc ytggagcctg g                                               21


<210>  6057
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6057
tagtagtgtt ytttgggcct g                                               21


<210>  6058
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6058
gagcatagga ytttactttt g                                               21


<210>  6059
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6059
tgtaagtagc ycagaacagg g                                               21


<210>  6060
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6060
actggccatt ygatttggga c                                               21


<210>  6061
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6061
agcaaaccca rcctggagtg g                                               21


<210>  6062
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6062
tattgtcgcc ygggtgctgt g                                               21


<210>  6063
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6063
ggcaacaaca yaggaattga g                                               21


<210>  6064
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6064
gggtttggag kgatttgtca t                                               21


<210>  6065
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6065
tgcattttgg rtgtttgatt g                                               21


<210>  6066
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6066
agatggaggc rcagtcaagg a                                               21


<210>  6067
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6067
ttgatatgac yagacatttt a                                               21


<210>  6068
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6068
gccatgctcc yctttgcatt t                                               21


<210>  6069
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6069
agttgctggg ycctagaatg c                                               21


<210>  6070
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6070
aagtgtgaga yattattgtc c                                               21


<210>  6071
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6071
atcttggagg kaatctttgc t                                               21


<210>  6072
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6072
tgtgaactct ycttggcctt t                                               21


<210>  6073
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6073
ccatggtttc yctgcagatt t                                               21


<210>  6074
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6074
tatcagactt mttaatatct t                                               21


<210>  6075
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6075
gtttttaatt yctatggatc t                                               21


<210>  6076
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6076
atcttattta mccccaagct t                                               21


<210>  6077
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6077
tcagatagat rtggattcag a                                               21


<210>  6078
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6078
ccactgtggg rcttggcctc a                                               21


<210>  6079
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6079
ccaactcacc raagctccat g                                               21


<210>  6080
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6080
gggagcaagc rtcttggagg a                                               21


<210>  6081
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6081
aatacaggat ytttcttgtt t                                               21


<210>  6082
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6082
cttaattgtc rtacatacaa t                                               21


<210>  6083
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6083
tgccttcatt mtctcatcct t                                               21


<210>  6084
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6084
catccttata raagggttca a                                               21


<210>  6085
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6085
ctatcatcta yggcaaactg t                                               21


<210>  6086
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6086
cacagaacag ygatccaact c                                               21


<210>  6087
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6087
ctctaaattg ygaataatgt t                                               21


<210>  6088
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6088
tgaaggataa yaaaataatt c                                               21


<210>  6089
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6089
ggaggaacaa yaaagaagat g                                               21


<210>  6090
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6090
tctgattccc rtaatgttct a                                               21


<210>  6091
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6091
cagttggagt ycagagagca t                                               21


<210>  6092
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6092
cagcagcctt yaattgatat t                                               21


<210>  6093
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6093
gagtaagaga yataaaatag g                                               21


<210>  6094
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6094
ttgaagacaa rgagatccct t                                               21


<210>  6095
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6095
agaactgtct rtgtgtaagg t                                               21


<210>  6096
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6096
tgtccttttc rtgggatgag g                                               21


<210>  6097
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6097
atacttgtca ygagagggta a                                               21


<210>  6098
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6098
ggacaaagat rtattactcc a                                               21


<210>  6099
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6099
gcgcaaagga yacatggaga a                                               21


<210>  6100
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6100
tagttctata yggtggataa a                                               21


<210>  6101
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6101
aaggtaccac rggacacata t                                               21


<210>  6102
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6102
tgtgaacttg ycttggtaat t                                               21


<210>  6103
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6103
ttcctgtgtc rtatcttttt t                                               21


<210>  6104
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6104
aaagcattta ycatcgttta a                                               21


<210>  6105
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6105
aggtactccc ycaaacctct a                                               21


<210>  6106
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6106
atgccccccc yccaaaaaaa c                                               21


<210>  6107
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6107
tgtcttcatc mattgttctt t                                               21


<210>  6108
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6108
tttggctgca ragccagtaa a                                               21


<210>  6109
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6109
ctgttcatgg ytgttaacac t                                               21


<210>  6110
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6110
ttgagtaaga yagatactga g                                               21


<210>  6111
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6111
tggaatatga rtccacaaat g                                               21


<210>  6112
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6112
tattcaataa ygttaaaagc a                                               21


<210>  6113
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6113
atttcataat rctgggtaag t                                               21


<210>  6114
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6114
gaagggataa rttctagcgt t                                               21


<210>  6115
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6115
tccatgggta yttccaaagg t                                               21


<210>  6116
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6116
ttttctgcct rttagtcctt g                                               21


<210>  6117
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6117
caaaacatcg yctgtcagtt c                                               21


<210>  6118
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6118
ccaacctggg magagtattt t                                               21


<210>  6119
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6119
aagttcatac kgtattccta t                                               21


<210>  6120
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6120
gtatccttta rcaggagaac a                                               21


<210>  6121
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6121
cagaattaaa rccattttct c                                               21


<210>  6122
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6122
gggaaaaact rgagaagagg a                                               21


<210>  6123
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6123
ctaaatcaag kagctggtat c                                               21


<210>  6124
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6124
ccaaaagggt ygaggatcgc t                                               21


<210>  6125
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6125
caaaaattcc rggtatgagt g                                               21


<210>  6126
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6126
taatccaaag mgactgattt a                                               21


<210>  6127
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6127
ctttcctcac rgtattgtgg t                                               21


<210>  6128
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6128
ggttagaaga mctctatcta a                                               21


<210>  6129
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6129
tatggcagta ycaggagaaa g                                               21


<210>  6130
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6130
ctgtgatgaa ygactattaa c                                               21


<210>  6131
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6131
gggcctccag rcatgggttc a                                               21


<210>  6132
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6132
aatagagaca rtcatatgct a                                               21


<210>  6133
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6133
gattttagca kctgctgtct t                                               21


<210>  6134
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6134
cttgtgtctc macattttgt a                                               21


<210>  6135
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6135
gacaattaga racacacata t                                               21


<210>  6136
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6136
tttattattg kccagttagg c                                               21


<210>  6137
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6137
aactaactct yaaaaaaagt t                                               21


<210>  6138
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6138
gcataaagat katcagttct a                                               21


<210>  6139
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6139
atcgcagctg yagtaaaaaa g                                               21


<210>  6140
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6140
aaaaaccaca yaatatcata c                                               21


<210>  6141
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6141
attaaaaaac ygaaaaagag g                                               21


<210>  6142
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6142
ctccagttga kagtagtttc t                                               21


<210>  6143
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6143
ttgcaaaatg rgaataatag t                                               21


<210>  6144
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6144
tctgagttca mctttcttct t                                               21


<210>  6145
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6145
ctattgtttt ktatgtagtc t                                               21


<210>  6146
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6146
ttttaaagga ytgtgggccc a                                               21


<210>  6147
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6147
catactacat rggttacaca g                                               21


<210>  6148
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6148
tatataacaa yagagacaca t                                               21


<210>  6149
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6149
cgtaaatcct yctgagtaac a                                               21


<210>  6150
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6150
cacaaaaaaa ktttgtaata a                                               21


<210>  6151
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6151
ctttcctatt ycactactat a                                               21


<210>  6152
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6152
ttcctcttaa yaggagccct a                                               21


<210>  6153
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6153
acacaaaagc yaccattctc c                                               21


<210>  6154
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6154
acgttcttca rtataaattg c                                               21


<210>  6155
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6155
acttggcatg ratagttgct t                                               21


<210>  6156
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6156
aaaagaaggt ygttaaggca a                                               21


<210>  6157
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6157
tcttgaaata racatttttc a                                               21


<210>  6158
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6158
caaagagctc mtgtaataag g                                               21


<210>  6159
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6159
gcttttccac rctcttatgg t                                               21


<210>  6160
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6160
agtaggaata yaagcttcac a                                               21


<210>  6161
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6161
gacaattaat magctggaga g                                               21


<210>  6162
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6162
tttcattttc yggaaggtag a                                               21


<210>  6163
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6163
aaccctgata yaatatctat c                                               21


<210>  6164
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6164
gactgtcact ygttatcttt c                                               21


<210>  6165
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6165
tgtgcctttc rcatataatt a                                               21


<210>  6166
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6166
ctaaagcaag rtgccagacc a                                               21


<210>  6167
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6167
tggtgctatt ycttggaaga g                                               21


<210>  6168
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6168
ctctgatagt mccacctaag t                                               21


<210>  6169
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6169
attcctaatt ytggttctag a                                               21


<210>  6170
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6170
tttggatata ragatagact t                                               21


<210>  6171
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6171
tagaaaaccc raacttctct a                                               21


<210>  6172
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6172
ggcgctctcc ygatggtggt t                                               21


<210>  6173
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6173
aaatttattg yaaagctctg t                                               21


<210>  6174
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6174
ccaagcgaat raattggtac t                                               21


<210>  6175
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6175
acccacaggg rtagaggcca t                                               21


<210>  6176
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6176
gtaactgcat ygtacccaac c                                               21


<210>  6177
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6177
ccagcactgt rggtctctgc a                                               21


<210>  6178
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6178
tttctgtacc rtatgtaagc a                                               21


<210>  6179
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6179
agatctaatc rcgtaaggat a                                               21


<210>  6180
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6180
caaaagctga ycttgtcctt t                                               21


<210>  6181
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6181
tttgatatgt rcagatttct c                                               21


<210>  6182
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6182
attaccttta matttaatag g                                               21


<210>  6183
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6183
caggatgacc yaatttcacc t                                               21


<210>  6184
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6184
ttgaaggaat rgatggaatt t                                               21


<210>  6185
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6185
catttttttc rtcttctcct g                                               21


<210>  6186
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6186
caaaaagaca rtgtttaaaa c                                               21


<210>  6187
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6187
atttaaagac rtctcccaag g                                               21


<210>  6188
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6188
atcctaaaaa rtgggggctt t                                               21


<210>  6189
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6189
cttcattctc ycacctaaac a                                               21


<210>  6190
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6190
gtgagggagt rggcagctcc c                                               21


<210>  6191
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6191
cacaagtcag ytggcatttt a                                               21


<210>  6192
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6192
tgcacggtcc rtgaaatgtg c                                               21


<210>  6193
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6193
aactacaggc rtgatcttct c                                               21


<210>  6194
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6194
gcataattaa yctgcttgct g                                               21


<210>  6195
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6195
aaatgaagac mctgtagaac a                                               21


<210>  6196
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6196
ccaataagcc rtacaatcta a                                               21


<210>  6197
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6197
atacgcgctt ktcctgaaaa c                                               21


<210>  6198
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6198
ctcatcccaa yatatcatgg g                                               21


<210>  6199
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6199
tgtgacatca rtctaagtat c                                               21


<210>  6200
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6200
caagtttgca rtgtttgtac a                                               21


<210>  6201
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6201
tcctctcaga yttacattcc t                                               21


<210>  6202
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6202
atcttaatct yatctctgac t                                               21


<210>  6203
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6203
gctattaaca rtaggtaact c                                               21


<210>  6204
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6204
gtctgatggg rtttctttat t                                               21


<210>  6205
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6205
cattttgctg ytctacaagt a                                               21


<210>  6206
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6206
gtttaaaact rtgaaagatg t                                               21


<210>  6207
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6207
ccctccacct rtgactgtat c                                               21


<210>  6208
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6208
tgctgataga ygccttcatg a                                               21


<210>  6209
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6209
tttaaaacag ycagatctta t                                               21


<210>  6210
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6210
gaactcacta ycatgagggc a                                               21


<210>  6211
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6211
cttggttata mgctttaaag a                                               21


<210>  6212
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6212
agtgttgtaa yaagttttaa t                                               21


<210>  6213
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6213
tgatccaaag ktgactgagt g                                               21


<210>  6214
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6214
caaactaaaa yaaaaccagt c                                               21


<210>  6215
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6215
gcacacattt mctgaggcct a                                               21


<210>  6216
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6216
attgcacgat rtgatgggta c                                               21


<210>  6217
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6217
gatttctcta mtctattttt c                                               21


<210>  6218
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6218
tccaggagga rtggaccttc a                                               21


<210>  6219
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6219
attgttaaat raactttaca t                                               21


<210>  6220
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6220
accgaaatca yctgctactg t                                               21


<210>  6221
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6221
gagtctggct yattcaattc c                                               21


<210>  6222
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6222
agtgtgctca rtgttctttc t                                               21


<210>  6223
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6223
tccgtgccta ragaatgcag a                                               21


<210>  6224
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6224
cattaattgt rtatcagaat t                                               21


<210>  6225
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6225
ttttgcttct rtctctcatg t                                               21


<210>  6226
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6226
gcatattttg rtggttagat a                                               21


<210>  6227
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6227
tctgttttgt rttctccaca g                                               21


<210>  6228
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6228
acaagaatac rtttctggct a                                               21


<210>  6229
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6229
gtgtaaatta rtaggtttga g                                               21


<210>  6230
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6230
gaattgagct rttcagagag a                                               21


<210>  6231
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6231
atggcatagt yttctatgga g                                               21


<210>  6232
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6232
ctcatggacg mctttaaaga g                                               21


<210>  6233
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6233
ttagcccaaa rtgagaacat a                                               21


<210>  6234
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6234
aagaggagac kcagttggac a                                               21


<210>  6235
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6235
agtctattct ktaaatcata a                                               21


<210>  6236
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6236
aataattttc yttggtaact g                                               21


<210>  6237
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6237
tgtttaggat ragtaatttg g                                               21


<210>  6238
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6238
ggagatcttc ytggctttca g                                               21


<210>  6239
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6239
tttaatactt ygagatatat g                                               21


<210>  6240
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6240
taagatgctt ygggtttgtg a                                               21


<210>  6241
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6241
taagaaaaca ytttaatctc c                                               21


<210>  6242
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6242
cattcaagtc rtgcttgtct g                                               21


<210>  6243
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6243
ctcacacaaa yggtgacaaa t                                               21


<210>  6244
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6244
gcaaggattg rattagaggg a                                               21


<210>  6245
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6245
tgtgggtgca yttgaaatgc a                                               21


<210>  6246
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6246
atgaataata ragaacttag a                                               21


<210>  6247
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6247
aaacaatatg rcaaacacaa a                                               21


<210>  6248
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6248
taattcctca kgtctgcagg g                                               21


<210>  6249
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6249
aatgtgatga yatgtatcct t                                               21


<210>  6250
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6250
agtcatttac yttatatttc t                                               21


<210>  6251
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6251
ttccaagatg maggaaattt g                                               21


<210>  6252
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6252
ccagaaagta kgctttcttt g                                               21


<210>  6253
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6253
cctaaaagct ratgatttac c                                               21


<210>  6254
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6254
gtctatttta yttgttttgg c                                               21


<210>  6255
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6255
gcagatattt kttgaatgaa t                                               21


<210>  6256
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6256
acaaaatgag mgcttgtgga a                                               21


<210>  6257
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6257
tgtaagaaaa mgtacaatgg a                                               21


<210>  6258
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6258
tcccagaaga mtcgctgatc t                                               21


<210>  6259
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6259
atcctggaat ytaaaaccta t                                               21


<210>  6260
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6260
actccacata mcccatcaat g                                               21


<210>  6261
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6261
agatacaaac rttgaatgcg a                                               21


<210>  6262
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6262
gctgtcccct mttgacattg a                                               21


<210>  6263
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6263
ttcattctta ycaagttgac a                                               21


<210>  6264
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6264
tgaggctttt ygaagaatat t                                               21


<210>  6265
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6265
agtggtcatg ktttaggaac a                                               21


<210>  6266
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6266
ccatcagccc rtcatctccg c                                               21


<210>  6267
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6267
ttcagctttg rtactcatgt t                                               21


<210>  6268
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6268
atcaattttt katctctgaa t                                               21


<210>  6269
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6269
aggcattaac ytcagtttga a                                               21


<210>  6270
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6270
tgattacttg mataaattga a                                               21


<210>  6271
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6271
tgaattttag ratatgagac a                                               21


<210>  6272
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6272
gaggcattag ktgtctaatt t                                               21


<210>  6273
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6273
tatcagcaaa rcatgatttt t                                               21


<210>  6274
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6274
gcatgtgttc ygtaactaac t                                               21


<210>  6275
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6275
aggagagttc rgttgtcttc t                                               21


<210>  6276
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6276
gcacagatta ytgaacgtat t                                               21


<210>  6277
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6277
ccaatgtttt mgttttaaaa a                                               21


<210>  6278
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6278
ttgccacaca rtgactggaa a                                               21


<210>  6279
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6279
actcactgta mataccaaca t                                               21


<210>  6280
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6280
agttatgcac yctgccatgg a                                               21


<210>  6281
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6281
cagatggatg rttttcagat t                                               21


<210>  6282
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6282
acatagaaat ratgtatttg g                                               21


<210>  6283
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6283
tgttacaaag raacacacaa t                                               21


<210>  6284
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6284
cctcccctct ycctggttta a                                               21


<210>  6285
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6285
agaaattcag ytgagggctc a                                               21


<210>  6286
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6286
aagcaacact rtgaatgcta g                                               21


<210>  6287
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6287
caacaatctc yttttaaaag a                                               21


<210>  6288
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6288
tgaaactccc rtagtagttg g                                               21


<210>  6289
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6289
ctaagcttgg rtactgtggt c                                               21


<210>  6290
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6290
tctgttctct rcttcttctg a                                               21


<210>  6291
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6291
tgtatggaga maattatagt g                                               21


<210>  6292
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6292
ctcctatggg raaaagattt a                                               21


<210>  6293
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6293
cctcaataac rttgattttt t                                               21


<210>  6294
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6294
cattgtgcca yagttgtatt t                                               21


<210>  6295
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6295
tattattagc rttattttta t                                               21


<210>  6296
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6296
aaaacacaaa mgtcactagt c                                               21


<210>  6297
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6297
tttgaaattg rcagtgtttt t                                               21


<210>  6298
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6298
tcaaaatatt rtttgacttc a                                               21


<210>  6299
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6299
agcttaatga ytgatcaaat t                                               21


<210>  6300
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6300
cctgtatact rggaggaaat a                                               21


<210>  6301
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6301
tatacctaca katttttttt g                                               21


<210>  6302
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6302
tttctttcca ygatgtaaac a                                               21


<210>  6303
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6303
tggtcaggta rctctctgat g                                               21


<210>  6304
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6304
tatgatatga rcacaggatg a                                               21


<210>  6305
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6305
ttctaccatc ytaatctatt t                                               21


<210>  6306
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6306
tatcacatac ktggaataaa g                                               21


<210>  6307
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6307
ttagacaatg rttttctata t                                               21


<210>  6308
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6308
caaattgagt ytggagaata t                                               21


<210>  6309
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6309
tatcaagggg rcaataacca t                                               21


<210>  6310
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6310
aatagacaaa ygaacaagca t                                               21


<210>  6311
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6311
atacatgcaa rgaggtatgg a                                               21


<210>  6312
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6312
aggttttaat rtatttacag c                                               21


<210>  6313
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6313
atgttactac ktacactgtg t                                               21


<210>  6314
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6314
gaaaatggca ycatggaggg t                                               21


<210>  6315
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6315
aaagctaagc rtgttacctg a                                               21


<210>  6316
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6316
aattttccat ytatatcagc c                                               21


<210>  6317
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6317
atacagtgtt rtcagaaaga a                                               21


<210>  6318
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6318
catcttcctc kctgttcgtg t                                               21


<210>  6319
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6319
cagttttgta yaacattttg c                                               21


<210>  6320
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6320
tttcatggac yaggcccagg g                                               21


<210>  6321
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6321
tcctttaagt yttactgatt a                                               21


<210>  6322
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6322
tggatagata mcagagttaa t                                               21


<210>  6323
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6323
gtaaactaac rtgccattac c                                               21


<210>  6324
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6324
gaaatgaaga rtaccttctc a                                               21


<210>  6325
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6325
ttgttaatag maagtgattg t                                               21


<210>  6326
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6326
tatgtcaatg mtcatttata a                                               21


<210>  6327
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6327
ttatatatga ygatttccct c                                               21


<210>  6328
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6328
ctatccgtaa matgctagtt t                                               21


<210>  6329
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6329
attttattag yttcaaatgc c                                               21


<210>  6330
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6330
cttctgcaag yccttgggca t                                               21


<210>  6331
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6331
tctatctatt yggtctttct a                                               21


<210>  6332
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6332
tgtttggttg mccccatttt t                                               21


<210>  6333
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6333
ctaatctcta rtaagaagct g                                               21


<210>  6334
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6334
tccagctagc yatccacaaa c                                               21


<210>  6335
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6335
tggaactgtt ygctgtgcaa g                                               21


<210>  6336
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6336
atttcaaaaa rtgtatgagt t                                               21


<210>  6337
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6337
ttatacacaa ytgcagagtt t                                               21


<210>  6338
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6338
aacgccccag ycctgtctcc t                                               21


<210>  6339
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6339
tcaaaggaca ktgaaagaca t                                               21


<210>  6340
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6340
aacttggata kaagaagaga a                                               21


<210>  6341
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6341
ttttgggtca ygaccttgga g                                               21


<210>  6342
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6342
gtcatgaatt matgatttgt g                                               21


<210>  6343
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6343
cttcctatta yttgtgagga g                                               21


<210>  6344
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6344
ttgcatacct rtgatttcag g                                               21


<210>  6345
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6345
cagaataaat rggaaaagga a                                               21


<210>  6346
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6346
accaaaatca rtcaacaaaa g                                               21


<210>  6347
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6347
gctgactcga yggtggcatg g                                               21


<210>  6348
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6348
tgtaaagctc ygggcctgga t                                               21


<210>  6349
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6349
tggcagcacc rcacggaaca c                                               21


<210>  6350
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6350
acgcagggag ygctgcctgt a                                               21


<210>  6351
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6351
ttaggtcttg kctccaaatt c                                               21


<210>  6352
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6352
accattcccc rctcacagtt t                                               21


<210>  6353
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6353
caggagcacc rtcctttccc a                                               21


<210>  6354
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6354
cacttaagct rggaaatttg t                                               21


<210>  6355
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6355
atttgcatct ygaacagtgg g                                               21


<210>  6356
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6356
ctcagctttc rcatgcttct g                                               21


<210>  6357
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6357
agagtgggat ygagacctaa g                                               21


<210>  6358
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6358
attatctcct ycctctgtag c                                               21


<210>  6359
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6359
agtcacatat ygtaaggaac t                                               21


<210>  6360
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6360
agctttagga ygtatcagtt a                                               21


<210>  6361
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6361
taaattaaac ragaagcaac a                                               21


<210>  6362
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6362
ctttctggaa raaacaccga a                                               21


<210>  6363
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6363
ccctagagag kctatgtggt g                                               21


<210>  6364
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6364
gcaccatccc kctgtccgca t                                               21


<210>  6365
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6365
attttgttca rttgtcagca a                                               21


<210>  6366
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6366
ctgtggtgat rtgtcacaat t                                               21


<210>  6367
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6367
gacggaggct rtactgctag t                                               21


<210>  6368
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6368
atgtttaaca rcaaaactga c                                               21


<210>  6369
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6369
agccagcctc kggcatgtac a                                               21


<210>  6370
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6370
agattagtca ytcttctgcc t                                               21


<210>  6371
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6371
gtgattctca rccgtgttgc t                                               21


<210>  6372
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6372
tatctagtgg ytagtggcca g                                               21


<210>  6373
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6373
tataggatat ygcctaatcc c                                               21


<210>  6374
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6374
aatcttaaat mtacctgtta c                                               21


<210>  6375
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6375
tcatgagatc raccagcttt c                                               21


<210>  6376
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6376
tagcacacac rcccagttcc t                                               21


<210>  6377
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6377
acttcacacc maagcagttg t                                               21


<210>  6378
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6378
tttctcaata yaaagtggaa a                                               21


<210>  6379
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6379
ataagtatca kaagcctttt t                                               21


<210>  6380
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6380
tagtggaaag rgacattgta t                                               21


<210>  6381
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6381
gacacacaca maaaaaaaac c                                               21


<210>  6382
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6382
agttttatgg rtcttttgga t                                               21


<210>  6383
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6383
ccctaaaata rctactgtta a                                               21


<210>  6384
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6384
aatattaaca rttatttatt g                                               21


<210>  6385
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6385
atacacatat yacgtaacac a                                               21


<210>  6386
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6386
ggtctttggt rgccttaatt a                                               21


<210>  6387
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6387
ttggtgcaag mtctcaagca g                                               21


<210>  6388
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6388
ttaaaaaatc rgataagtag a                                               21


<210>  6389
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6389
acagctgtgg yttcataggt c                                               21


<210>  6390
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6390
attgcatttc rctgatcaaa c                                               21


<210>  6391
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6391
gatcatagtc rttttgcatc c                                               21


<210>  6392
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6392
taaataaacc raagtgatta c                                               21


<210>  6393
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6393
agctttggct ygtccaccca a                                               21


<210>  6394
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6394
ctttcatctg raaaaaaaat c                                               21


<210>  6395
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6395
tgtctgagga rggatttatt t                                               21


<210>  6396
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6396
ttttaaatgt mgaacagtta c                                               21


<210>  6397
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6397
ttcccattgt yttagcagtc t                                               21


<210>  6398
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6398
gatttgcagc rtcattcctc t                                               21


<210>  6399
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6399
cataaccaca ygtgtccttc t                                               21


<210>  6400
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6400
atctgcaaaa raaattacat a                                               21


<210>  6401
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6401
agcttactaa rtttctgaag g                                               21


<210>  6402
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6402
ttctcttaga rtgatatttg g                                               21


<210>  6403
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6403
taaagatttt yatacctgaa t                                               21


<210>  6404
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6404
agaaaaagga rtgtatttat t                                               21


<210>  6405
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6405
agttattgtg yatctcaaga t                                               21


<210>  6406
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6406
gagccgacac yttgtttttg a                                               21


<210>  6407
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6407
gtcttctaat yatactattc a                                               21


<210>  6408
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6408
acttgactgg rccacaggat g                                               21


<210>  6409
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6409
gaaatacaga ygacagaaaa a                                               21


<210>  6410
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6410
gcaaattaca ygacttgtct g                                               21


<210>  6411
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6411
tatttactca ytcaactctc a                                               21


<210>  6412
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6412
cccttgatgg yacaggctga a                                               21


<210>  6413
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6413
gagaaaagaa yacatgatca g                                               21


<210>  6414
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6414
cagactctaa ygccatcata a                                               21


<210>  6415
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6415
cataataaaa mctctgataa c                                               21


<210>  6416
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6416
cactgagcaa ractcattta t                                               21


<210>  6417
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6417
gcccccttcc rcctgcttta c                                               21


<210>  6418
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6418
gcactctgaa yttggaaccc c                                               21


<210>  6419
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6419
agcggaggca yttaaaacaa g                                               21


<210>  6420
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6420
caattttctt yaaccttcca t                                               21


<210>  6421
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6421
gtgaaagagt maaaattctc t                                               21


<210>  6422
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6422
agagtaccct ytcctgactc t                                               21


<210>  6423
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6423
ggtacatttc yctgaaagat a                                               21


<210>  6424
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6424
taacttaagt ytgacatata c                                               21


<210>  6425
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6425
agataaaaca mcactagggg a                                               21


<210>  6426
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6426
gccccaggcc rgcggttctc c                                               21


<210>  6427
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6427
taactaatta ytgatttctg g                                               21


<210>  6428
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6428
atgccaacac matttcatgg g                                               21


<210>  6429
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6429
gggccccctt rctctttgta g                                               21


<210>  6430
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6430
tataacatca yaaggagtca a                                               21


<210>  6431
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6431
tcacacttca raatgatgca g                                               21


<210>  6432
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6432
cctaggtaag kcctgatgca g                                               21


<210>  6433
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6433
gacatatgat rtaattactg g                                               21


<210>  6434
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6434
ttcattttgt yatgtagaag a                                               21


<210>  6435
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6435
gatttacaat ktaaaatgag t                                               21


<210>  6436
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6436
gacactactt kctttgcaga a                                               21


<210>  6437
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6437
cagtacataa rgggaggctc t                                               21


<210>  6438
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6438
ggaactgtta ytgctccatt a                                               21


<210>  6439
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6439
tatccaaatg ycaaggccta c                                               21


<210>  6440
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6440
aatgtctcct raactataaa c                                               21


<210>  6441
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6441
atatttctca ycacctgaca g                                               21


<210>  6442
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6442
catatgatac raagataact a                                               21


<210>  6443
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6443
tacatagtga ragcttaaga a                                               21


<210>  6444
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6444
tatgcccaca maaaactaca g                                               21


<210>  6445
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6445
agcaccagtg rgaagctgac c                                               21


<210>  6446
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6446
agggagttaa rcttcctgcc c                                               21


<210>  6447
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6447
gcaggagatc yggatacaca g                                               21


<210>  6448
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6448
ataaagcctt yatttgtatt g                                               21


<210>  6449
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6449
ttccccttgt ratttaaata g                                               21


<210>  6450
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6450
tgagggctct ytaaactctc a                                               21


<210>  6451
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6451
tttcctatcc rtgtcatttt g                                               21


<210>  6452
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6452
atatgtcaat rgaactctga t                                               21


<210>  6453
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6453
aatcataaag yatttggaca t                                               21


<210>  6454
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6454
aatgttaaaa yagagaggaa a                                               21


<210>  6455
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6455
ccaaagttat ygaagcaatc t                                               21


<210>  6456
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6456
gtcttccttt rtgaggtgtc t                                               21


<210>  6457
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6457
ttcagtgtct rtagaagact c                                               21


<210>  6458
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6458
tttcttatgg ytcccctcca c                                               21


<210>  6459
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6459
tactagcaaa ygtaatatag c                                               21


<210>  6460
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6460
atataaaaag yagccaaatg t                                               21


<210>  6461
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6461
gggaggcgat raggaaaaca a                                               21


<210>  6462
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6462
agaacaccag mtagattcaa a                                               21


<210>  6463
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6463
gtttttagat rggtctattt g                                               21


<210>  6464
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6464
tggtttctta ytactgagtt t                                               21


<210>  6465
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6465
actctgagga ygcaggccag c                                               21


<210>  6466
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6466
accgtccccc yaacccacag a                                               21


<210>  6467
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6467
gcaagcatga yagaaacctt t                                               21


<210>  6468
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6468
taaattaaat ragcaggaac c                                               21


<210>  6469
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6469
accagtctca rtgtcttaag c                                               21


<210>  6470
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6470
ttacaaagca ygtggagtca g                                               21


<210>  6471
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6471
tcttctacca ygtgaagact t                                               21


<210>  6472
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6472
catgcaaatg yccctgttta g                                               21


<210>  6473
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6473
tatttcatgt rggaaagtat c                                               21


<210>  6474
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6474
gtaatgcaga rgatagttta a                                               21


<210>  6475
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6475
tcttcaaccg kacgtaccat g                                               21


<210>  6476
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6476
aagttcctgt yattccttct t                                               21


<210>  6477
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6477
tccatctttc rtcatcatta a                                               21


<210>  6478
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6478
atataatcaa ygcccctaca t                                               21


<210>  6479
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6479
aggaaccaga yaggatccat g                                               21


<210>  6480
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6480
agccataatc yctctgtgaa t                                               21


<210>  6481
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6481
atttcattat ycacccgaaa g                                               21


<210>  6482
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6482
atggtcaagt mccacataat g                                               21


<210>  6483
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6483
ttgttcatta rtttgtggtt a                                               21


<210>  6484
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6484
tttttaataa ygatagataa t                                               21


<210>  6485
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6485
ttcttcttct rtcctatttt c                                               21


<210>  6486
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6486
ttttccaaat kattaatcta a                                               21


<210>  6487
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6487
taggcttcct rtcataactg c                                               21


<210>  6488
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6488
cttaagaaac ygtaattttt g                                               21


<210>  6489
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6489
actgtgtgaa ygtttcaagc c                                               21


<210>  6490
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6490
agaaacaacc raaaataata t                                               21


<210>  6491
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6491
caacaaactg yacaacaaag a                                               21


<210>  6492
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6492
aatggaatgc rcctcacctc t                                               21


<210>  6493
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6493
tttatttgcc rcttataatc t                                               21


<210>  6494
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6494
atagacttta raattcacta a                                               21


<210>  6495
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6495
ataggtcaga mtatgagaaa g                                               21


<210>  6496
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6496
tttctttata kcagcttaat g                                               21


<210>  6497
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6497
gcataggaaa maattcttca g                                               21


<210>  6498
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6498
agaaggaatg yctttctgtg g                                               21


<210>  6499
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6499
ttcagttgag rggatcaatt t                                               21


<210>  6500
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6500
aggagagcaa rggagggaga g                                               21


<210>  6501
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6501
gggacacccc rtggcaatcc t                                               21


<210>  6502
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6502
gaagagttgc rgggtgtgca g                                               21


<210>  6503
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6503
attggttaag rgttcagtct t                                               21


<210>  6504
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6504
atactgtgct kttgctgtct t                                               21


<210>  6505
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6505
gctcctggaa ractgatgct t                                               21


<210>  6506
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6506
gttcacttga ygcaaagtaa a                                               21


<210>  6507
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6507
cagaagaaac ytcaactgtg c                                               21


<210>  6508
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6508
tgatgatcct maaccataac c                                               21


<210>  6509
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6509
actctgaact mtgctgagaa g                                               21


<210>  6510
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6510
agtttgtttt yaaaagtcac a                                               21


<210>  6511
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6511
ggtaaactac rgaattgcag g                                               21


<210>  6512
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6512
gggccaactt macacagtta c                                               21


<210>  6513
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6513
aaattctctg yagaagaggc a                                               21


<210>  6514
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6514
ttatggctgg ytagcatctt c                                               21


<210>  6515
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6515
acaaaagata yaaacaggca a                                               21


<210>  6516
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6516
ctctgatgta rttggtatgg t                                               21


<210>  6517
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6517
tttggtttaa ygagggatag g                                               21


<210>  6518
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6518
gtctcatgga yggggacaat g                                               21


<210>  6519
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6519
tgatatgatg ytatgttatg t                                               21


<210>  6520
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6520
tgccaccgaa kggtattaag c                                               21


<210>  6521
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6521
agcagtgcca ycagactcct c                                               21


<210>  6522
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6522
ggcagcttaa mggggatgtg t                                               21


<210>  6523
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6523
ggtgtctctg rcccaaatag c                                               21


<210>  6524
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6524
gtatacataa ktttaaagaa a                                               21


<210>  6525
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6525
aatgccagga mtgattcata g                                               21


<210>  6526
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6526
gtaaaacacc ygcgtcaggg t                                               21


<210>  6527
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6527
cccttttgaa yacacccatg t                                               21


<210>  6528
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6528
tctcaggaac ycccttggct c                                               21


<210>  6529
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6529
ctttactgag kcttgatcag a                                               21


<210>  6530
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6530
gttaactggt rcccattgca c                                               21


<210>  6531
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6531
aaaataaaac rcaacagcta g                                               21


<210>  6532
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6532
gtcactgagc ygcagcaggc g                                               21


<210>  6533
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6533
gaactggaaa rctgggaata t                                               21


<210>  6534
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6534
accaaaagag rtcagcctca g                                               21


<210>  6535
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6535
gcccatcttc rtggatttaa g                                               21


<210>  6536
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6536
atggaagagt rtctagttct a                                               21


<210>  6537
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6537
gggaagggac ygcatagttg g                                               21


<210>  6538
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6538
tccccttcgg raacagagca a                                               21


<210>  6539
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6539
agtccacagg ygctaccctg g                                               21


<210>  6540
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6540
cgggctagtg yatcctcctc a                                               21


<210>  6541
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6541
agtaaacgat yttatccaca a                                               21


<210>  6542
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6542
atagagaaca ycgttgtttt a                                               21


<210>  6543
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6543
tgagaatgta magcacacaa c                                               21


<210>  6544
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6544
tgggaagtga ytggggaagg g                                               21


<210>  6545
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6545
cctggccagc rtggaacgca a                                               21


<210>  6546
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6546
agaaacagac ytgctcagat c                                               21


<210>  6547
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6547
tactaatagg ygattgctgt a                                               21


<210>  6548
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6548
gccatacccc mtcctgttct c                                               21


<210>  6549
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6549
taaagaaaac ytgatctcgc c                                               21


<210>  6550
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6550
ctcttgtgac ytcatcctga c                                               21


<210>  6551
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6551
aacagcacca kgatgccttg t                                               21


<210>  6552
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6552
tctcatcttc kaagtgggca t                                               21


<210>  6553
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6553
gcaggctacc rtcccagctt t                                               21


<210>  6554
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6554
ttgaacccca rtttttcagt g                                               21


<210>  6555
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6555
ctcagtttgc raaacagacc t                                               21


<210>  6556
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6556
tgaactttac rtgaaaaaga a                                               21


<210>  6557
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6557
tttgtggaat rttcctatgc a                                               21


<210>  6558
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6558
ctaacctaat yatccttcaa g                                               21


<210>  6559
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6559
agagtgctgc ratcgcttga t                                               21


<210>  6560
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6560
ttcaggccta yctagcaggg c                                               21


<210>  6561
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6561
gagttacagt yattaaaatg g                                               21


<210>  6562
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6562
aaaagcaaaa raaaaaaaaa a                                               21


<210>  6563
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6563
ccagccacac ygaaactgta a                                               21


<210>  6564
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6564
tctgtgagac ygtagtgtct g                                               21


<210>  6565
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6565
ggtttgctta yagaatcact t                                               21


<210>  6566
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6566
gttgttctta yttgacatgg g                                               21


<210>  6567
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6567
gtattaatat ktctgatgag a                                               21


<210>  6568
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6568
agatgaagct raggctcaat a                                               21


<210>  6569
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6569
ggatacagtg rcatcatcac a                                               21


<210>  6570
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6570
agtttaaggc raaatgataa a                                               21


<210>  6571
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6571
gacgggcact rggagagaag a                                               21


<210>  6572
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6572
agttgctcaa rtaattggat a                                               21


<210>  6573
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6573
gtatgcctct ktttacaccc c                                               21


<210>  6574
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6574
gcatgtgtgc rtaaaacttc a                                               21


<210>  6575
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6575
ccccttcccc rtctctgaaa g                                               21


<210>  6576
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6576
gttcctgata yctgagcacc c                                               21


<210>  6577
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6577
gtagatttgc raatcagcag g                                               21


<210>  6578
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6578
ggagccacag ytgtcataaa t                                               21


<210>  6579
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6579
gcctaaccag rcccaagaca g                                               21


<210>  6580
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6580
ttggattgaa rttcccagat a                                               21


<210>  6581
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6581
aacagtgaac ycactacatg c                                               21


<210>  6582
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6582
ctacagcctg kctcagtttt c                                               21


<210>  6583
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6583
tgagattatg yagtcaggaa c                                               21


<210>  6584
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6584
cctcagggac rtgacagttc t                                               21


<210>  6585
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6585
aggttggaag mctgccgagg c                                               21


<210>  6586
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6586
cataaggctt ytctgacatc t                                               21


<210>  6587
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6587
gtgacagtgt ygcattgacc t                                               21


<210>  6588
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6588
taaaatacac rtaacataaa a                                               21


<210>  6589
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6589
tgaacacata yagtgcgtgt c                                               21


<210>  6590
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6590
taccatttcc rtaatcaaca t                                               21


<210>  6591
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6591
gagtctctct rtgcactctc a                                               21


<210>  6592
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6592
gaaagctctg yaaggctagg a                                               21


<210>  6593
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6593
ttcagaagtt kaggagaagt a                                               21


<210>  6594
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6594
ctcccactta rgttacagat g                                               21


<210>  6595
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6595
ttttgcccca ragcatctca t                                               21


<210>  6596
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6596
ggggacacca yacttccaaa g                                               21


<210>  6597
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6597
ataaaccaca ytgaacatgg a                                               21


<210>  6598
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6598
taaaaaatcg ragaatatat a                                               21


<210>  6599
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6599
acataaactt kccattaaca g                                               21


<210>  6600
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6600
gcctgatgtt ycccaccgat g                                               21


<210>  6601
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6601
tgttcgtctt kttctgcctg c                                               21


<210>  6602
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6602
gcgttggctt yacaatctgg c                                               21


<210>  6603
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6603
gatcagactt rctgaacctg t                                               21


<210>  6604
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6604
tttcccttac ytgtgaaaga t                                               21


<210>  6605
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6605
tccattcacc rgaccaatta a                                               21


<210>  6606
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6606
ccttgggtta raggctaggg t                                               21


<210>  6607
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6607
ccagggttac ytgtgaaaac a                                               21


<210>  6608
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6608
ttgcagggaa yggaccaagt a                                               21


<210>  6609
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6609
tcctggtcca rtcatctcca t                                               21


<210>  6610
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6610
agatggagaa maatgaagga g                                               21


<210>  6611
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6611
cacgtaaagt rctggtttaa t                                               21


<210>  6612
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6612
cttacattca yacaaaagcc g                                               21


<210>  6613
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6613
ggctgttatt yagggttttt t                                               21


<210>  6614
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6614
aaaaacggaa rggatggggg c                                               21


<210>  6615
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6615
gtcaaataga ygctggagat t                                               21


<210>  6616
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6616
gctttctctc raattagagt g                                               21


<210>  6617
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6617
agagagagaa rggatgcatt t                                               21


<210>  6618
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6618
atagttgggg ytaaggttgt t                                               21


<210>  6619
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6619
tgggaagcaa ytgggatgtg a                                               21


<210>  6620
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6620
ctccaccaaa rtctcaaagg g                                               21


<210>  6621
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6621
cctattgcct rcccttcacc a                                               21


<210>  6622
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6622
gctcaccagc rtgcttcacg a                                               21


<210>  6623
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6623
cagcgctcca yctcttccta c                                               21


<210>  6624
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6624
aagataaatg ragtctgcca a                                               21


<210>  6625
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6625
acatcacctc rggtaaagga a                                               21


<210>  6626
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6626
ataaaagtat yaataacaca c                                               21


<210>  6627
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6627
ataactgcaa rtaagtcaat g                                               21


<210>  6628
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6628
ccccacttca rttgtttatt a                                               21


<210>  6629
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6629
tacaactctc ytgttactta g                                               21


<210>  6630
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6630
gaccctgtgt rtatagagtt t                                               21


<210>  6631
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6631
tgtaagtttc rtaaaagcag g                                               21


<210>  6632
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6632
ggcgtgagaa rtgaggtgac g                                               21


<210>  6633
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6633
aaaggtgcac rtatcacttt t                                               21


<210>  6634
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6634
tgtctgtgga ytggaggatg t                                               21


<210>  6635
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6635
tcacataggt yattctatca c                                               21


<210>  6636
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6636
ggtgaaaagt kaaaacacta g                                               21


<210>  6637
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6637
catatttatc mgactgtatc c                                               21


<210>  6638
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6638
aggtaaatta rcttgtactc t                                               21


<210>  6639
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6639
agcacagtaa rgaaatgagc c                                               21


<210>  6640
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6640
catgcacaca rtacattaag g                                               21


<210>  6641
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6641
aaaacccaac mcatccttcc t                                               21


<210>  6642
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6642
acatcgctgc rggtcagaaa a                                               21


<210>  6643
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6643
ctctgaatat ycatttctct c                                               21


<210>  6644
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6644
tattggctga rcttgggcca g                                               21


<210>  6645
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6645
agcctcgtgc rttggtggct c                                               21


<210>  6646
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6646
gcctatggaa rgagggtccc c                                               21


<210>  6647
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6647
ggaagcctcc kcccacctcc a                                               21


<210>  6648
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6648
cactgtcccc ragtcactgg c                                               21


<210>  6649
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6649
gtgctctcag yagggtcagg c                                               21


<210>  6650
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6650
gagaccatcc ytctcatttt g                                               21


<210>  6651
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6651
tttagtgtgg ygtgggctca g                                               21


<210>  6652
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6652
tttgcttatt ygtatacttg t                                               21


<210>  6653
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6653
tagatggagg ygtggagaat g                                               21


<210>  6654
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6654
ggcaggaaac rtacaactct t                                               21


<210>  6655
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6655
cgggagttga raagaaacga t                                               21


<210>  6656
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6656
agcctgggac rctaaaccag c                                               21


<210>  6657
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6657
tgaggaagcg ycatcatgag c                                               21


<210>  6658
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6658
cagcctgacc kcatttttca a                                               21


<210>  6659
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6659
agaggacact ygagtctttc t                                               21


<210>  6660
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6660
tatcttaagg rccaattcca a                                               21


<210>  6661
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6661
ggcaaagaac rtcatgctag a                                               21


<210>  6662
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6662
aagacccctt mccactgctc t                                               21


<210>  6663
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6663
gtgcctaacc ygtatcctgt c                                               21


<210>  6664
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6664
cgatctctac ratcaagata g                                               21


<210>  6665
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6665
aactgatacc rtggaaggta a                                               21


<210>  6666
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6666
agactgggct raattgagag t                                               21


<210>  6667
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6667
aatgctacga ygatccggac a                                               21


<210>  6668
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6668
cttaatggat raacttttgt t                                               21


<210>  6669
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6669
agtaattagg rgagtgaaga c                                               21


<210>  6670
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6670
ctcagaatgc ygatttctct t                                               21


<210>  6671
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6671
ccggccattt yacatgggca t                                               21


<210>  6672
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6672
gaccaccagt ygcttaccaa a                                               21


<210>  6673
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6673
tcagaggaaa rgcatggcgg g                                               21


<210>  6674
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6674
agatagcttt yggaggaggg a                                               21


<210>  6675
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6675
gaatataaaa ytttttagaa a                                               21


<210>  6676
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6676
tttctagcca kctagggact t                                               21


<210>  6677
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6677
atatattagg yccagctggg c                                               21


<210>  6678
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6678
ggggatttta ytgtatccct g                                               21


<210>  6679
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6679
taaccaagaa rttaaatcaa t                                               21


<210>  6680
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6680
tgcatattca yccctcccta c                                               21


<210>  6681
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6681
ctttgtggca magtgaccat c                                               21


<210>  6682
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6682
atttggagcc ytttctgaaa c                                               21


<210>  6683
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6683
acttttcacg rgaatggtcc t                                               21


<210>  6684
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6684
aatttctcca rtgcttgtta t                                               21


<210>  6685
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6685
tatctacatc ytagccttag a                                               21


<210>  6686
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6686
gaggcctcta yattaacttc c                                               21


<210>  6687
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6687
tattttcttt matttttaag a                                               21


<210>  6688
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6688
acatttttcc ygtcctattc t                                               21


<210>  6689
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6689
tgggatctct rtcagtttcc t                                               21


<210>  6690
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6690
ccatatcact rctggcattt a                                               21


<210>  6691
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6691
tccttttatc mccctaaaac t                                               21


<210>  6692
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6692
ccccggcaca kccaaccaaa a                                               21


<210>  6693
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6693
tgttttgagc ycatgcagat c                                               21


<210>  6694
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6694
gttgaaccaa rgacactaac t                                               21


<210>  6695
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6695
gtgtgacccc rctcaaaaaa c                                               21


<210>  6696
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6696
gaatgtttca rttctgagga a                                               21


<210>  6697
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6697
aattttgcct yggtcattca a                                               21


<210>  6698
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6698
atctttcaac rttaaaacct g                                               21


<210>  6699
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6699
aggtagggtg rgtactggac a                                               21


<210>  6700
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6700
tagtcccatc ytactgtgat t                                               21


<210>  6701
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6701
gtttattttg ygctccttct a                                               21


<210>  6702
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6702
atttccttcc ycaagagttt t                                               21


<210>  6703
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6703
gtttctttca ytggctctga t                                               21


<210>  6704
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6704
tcatggtcct rttagatttt c                                               21


<210>  6705
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6705
tgtctgccta yattggtgag g                                               21


<210>  6706
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6706
gacccggaca ycaggaaggc t                                               21


<210>  6707
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6707
ttttgcatct rtaaatgtgg t                                               21


<210>  6708
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6708
ttagttgtcc mgttactttt t                                               21


<210>  6709
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6709
atgggtgagg kgttaacagc a                                               21


<210>  6710
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6710
cttttctgcc rcgtagggtg a                                               21


<210>  6711
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6711
cagaattgct mcttctgaga a                                               21


<210>  6712
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6712
atctctgtta ygttgataac t                                               21


<210>  6713
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6713
aatattttgt ytggcaatgg t                                               21


<210>  6714
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6714
aaaaaatgtc rctgtcagtt a                                               21


<210>  6715
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6715
actactgaac rttgattata a                                               21


<210>  6716
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6716
tactaaaatg yggagattaa g                                               21


<210>  6717
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6717
tggtggcctc ygaggaagaa c                                               21


<210>  6718
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6718
tacctgccgc ycggaacgcc a                                               21


<210>  6719
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6719
ttacacaaga yggaagatgt a                                               21


<210>  6720
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6720
ttctccactg yggttctaac a                                               21


<210>  6721
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6721
tgtttcaact rccaagcttt g                                               21


<210>  6722
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6722
cacccactac rtgagctact g                                               21


<210>  6723
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6723
caattatagg rggcactgct a                                               21


<210>  6724
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6724
agaaggccag ragtggctgg g                                               21


<210>  6725
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6725
agagaggaag ragggctctg g                                               21


<210>  6726
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6726
tctttctgtc yctgatctat c                                               21


<210>  6727
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6727
tgagtcatcc rcagggacta g                                               21


<210>  6728
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6728
ataaacttct rttgtgtcac a                                               21


<210>  6729
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6729
ttttctgact ratacagggg g                                               21


<210>  6730
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6730
atataacggg katggtaaca c                                               21


<210>  6731
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6731
tacatgactc rtacaatctt t                                               21


<210>  6732
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6732
cagacagtat rcatactatg a                                               21


<210>  6733
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6733
tgagactagc rtactggttc t                                               21


<210>  6734
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6734
ttctaacgaa rccttcacca a                                               21


<210>  6735
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6735
caagaaagtc yagtatctat t                                               21


<210>  6736
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6736
ggcgaccaaa yccccaactt t                                               21


<210>  6737
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6737
accatattag rcaaacctgg c                                               21


<210>  6738
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6738
gaatagggat yacatttcct c                                               21


<210>  6739
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6739
aacaaaatat ycttgaactg g                                               21


<210>  6740
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6740
tgttttcttg mccactggaa t                                               21


<210>  6741
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6741
agaaaatcca rtcatggtga a                                               21


<210>  6742
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6742
tagggaatga raaagtaatt a                                               21


<210>  6743
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6743
ttatctgact rttgagatta a                                               21


<210>  6744
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6744
atagatgtaa ytgcaggatg a                                               21


<210>  6745
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6745
aaacctattc ygttttcaaa g                                               21


<210>  6746
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6746
agatgcacat rcgttcctgc t                                               21


<210>  6747
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6747
ctccctttat kaagtttgtg t                                               21


<210>  6748
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6748
ttttttaaac rtcttgtgca t                                               21


<210>  6749
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6749
agtgtccttc mctaaaactc c                                               21


<210>  6750
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6750
gaaaatagac rtttagattt g                                               21


<210>  6751
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6751
catcacacat yctgggatta a                                               21


<210>  6752
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6752
ggaagacaac yaatatgtta t                                               21


<210>  6753
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6753
agagattgga ragaaagaag g                                               21


<210>  6754
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6754
ttgtttcatt kaagttagtt c                                               21


<210>  6755
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6755
ctgattggat rtgaccctcg g                                               21


<210>  6756
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6756
agggctaacc yacagggagt g                                               21


<210>  6757
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6757
cagcaaatgg kttgtgcaga c                                               21


<210>  6758
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6758
atattctgtc rtggtttaac c                                               21


<210>  6759
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6759
gttgcaggac rtcatgtgta t                                               21


<210>  6760
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6760
cagagccgcc ygcccacatg c                                               21


<210>  6761
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6761
cagccggaag rtcccccaaa g                                               21


<210>  6762
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6762
actcccccgg mctggaagaa g                                               21


<210>  6763
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6763
tgagaccagg racatagctg g                                               21


<210>  6764
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6764
gtctgcctta yaatttccaa g                                               21


<210>  6765
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6765
tttgctcagc ytccattgtg a                                               21


<210>  6766
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6766
ggttctctgg rtgcagcagc a                                               21


<210>  6767
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6767
tcaaaggcca rctgtatata c                                               21


<210>  6768
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6768
tgattatatc rcactcagct t                                               21


<210>  6769
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6769
tttttccttt ygtactttat a                                               21


<210>  6770
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6770
gggccccttg kattaccacc t                                               21


<210>  6771
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6771
ccacatttgc ygagagttag g                                               21


<210>  6772
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6772
cctttggcta ygtattagtc c                                               21


<210>  6773
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6773
ttttcctggc rtgaacccgt t                                               21


<210>  6774
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6774
tttggcgctg kggcctaaag a                                               21


<210>  6775
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6775
catgtctgcc rtttctgcag t                                               21


<210>  6776
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6776
agtctctttc ygtttttcag a                                               21


<210>  6777
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6777
catttttgtg rgtttattcc t                                               21


<210>  6778
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6778
ggagagcaca rccatctgtg g                                               21


<210>  6779
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6779
atgatgatgg kgacaatgat g                                               21


<210>  6780
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6780
gctgaagttc rgagctccag t                                               21


<210>  6781
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6781
aaacacagaa ygtctgacac a                                               21


<210>  6782
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6782
acaaacacac ygataaaatg t                                               21


<210>  6783
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6783
aggagatgca ratgtctctg t                                               21


<210>  6784
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6784
catttaagac kgctgctcca a                                               21


<210>  6785
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6785
ttggtgaaag ytcttgaact t                                               21


<210>  6786
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6786
attccaggat ratcccagga a                                               21


<210>  6787
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6787
tcccaggaac rtgtcttcat g                                               21


<210>  6788
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6788
tggttttgtc ytgctcactg t                                               21


<210>  6789
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6789
ccctggcatc yaaagccatt t                                               21


<210>  6790
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6790
gcaaatttcc rtcttcagag a                                               21


<210>  6791
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6791
gcacctggac rgaccaggag g                                               21


<210>  6792
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6792
accaggaatc ytcccccccg g                                               21


<210>  6793
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6793
tcagagaatc rtggtgggtc t                                               21


<210>  6794
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6794
gggccccaga rtcagtgctc t                                               21


<210>  6795
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6795
ctttaacatt yatagcttat t                                               21


<210>  6796
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6796
ggactgagcc yccttcactg g                                               21


<210>  6797
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6797
tcttgtcttc mggtaatttt c                                               21


<210>  6798
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6798
taattgaggt maagtaagat a                                               21


<210>  6799
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6799
gaacaagatg rgagtgttat g                                               21


<210>  6800
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6800
gtattttcca macatctctt c                                               21


<210>  6801
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6801
acgtgaagaa ygacctcaaa c                                               21


<210>  6802
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6802
agatgctggg ytaggtcaaa a                                               21


<210>  6803
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6803
agcctgttaa yggatgctct c                                               21


<210>  6804
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6804
tttttctgca rctccccagt c                                               21


<210>  6805
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6805
ctagcttttc rtgtccttac t                                               21


<210>  6806
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6806
ctcacagtac rtggtttcta g                                               21


<210>  6807
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6807
tggcagccag ygtctgcaag c                                               21


<210>  6808
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6808
aacatgcttt mtatatcaat t                                               21


<210>  6809
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6809
gtagtaagtt mccatgtgtt t                                               21


<210>  6810
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6810
ttccctgccc rcaagtgcta a                                               21


<210>  6811
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6811
gtttgcctct yataattata t                                               21


<210>  6812
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6812
ataatggtaa kattagtaac t                                               21


<210>  6813
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6813
gtttctctgt raaatcagtg a                                               21


<210>  6814
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6814
aggaagcttg yccactgtgt a                                               21


<210>  6815
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6815
tgagtgagag mcgatgaaga c                                               21


<210>  6816
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6816
ctttggagga rgaggatgca a                                               21


<210>  6817
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6817
tcaacagcag yactggacta t                                               21


<210>  6818
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6818
tgtgtgcata yatgactcaa a                                               21


<210>  6819
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6819
cattttagtg ycagtttagg a                                               21


<210>  6820
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6820
gaccctgaac ycatgaagct g                                               21


<210>  6821
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6821
cttttccaca mcctcttctg a                                               21


<210>  6822
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6822
gcctggacca ygctgatggc a                                               21


<210>  6823
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6823
gaagggccag rtgtagtggc t                                               21


<210>  6824
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6824
taacctttac rtatacctat c                                               21


<210>  6825
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6825
gaaatgtata yatgtaactt t                                               21


<210>  6826
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6826
caaaggcaat yatcaccttg a                                               21


<210>  6827
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6827
cataggatta ygcacactta c                                               21


<210>  6828
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6828
agaatctgca yccagaattg c                                               21


<210>  6829
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6829
gtaaatgatt rgctgtcgga t                                               21


<210>  6830
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6830
cctagcattc raagtcacat a                                               21


<210>  6831
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6831
cccaggagga ygctccactt g                                               21


<210>  6832
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6832
ggtggaaata yttcaatcag a                                               21


<210>  6833
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6833
aattttgata ragttcaacg t                                               21


<210>  6834
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6834
ccttatgagc ytggggcaca t                                               21


<210>  6835
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6835
ctcccacaca rgttcattcc t                                               21


<210>  6836
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6836
gagcactagg yggagtgttt t                                               21


<210>  6837
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6837
ggccctgggt rcttcatctt c                                               21


<210>  6838
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6838
tatggaaata ygatggacct a                                               21


<210>  6839
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6839
tgattccact kggaaaatgt t                                               21


<210>  6840
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6840
tgccccaccc yacatatgtt c                                               21


<210>  6841
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6841
taaagaaaaa yaaaggcttc t                                               21


<210>  6842
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6842
aagggctcta rtgagaaaag t                                               21


<210>  6843
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6843
aaaaaagaag katgatatac c                                               21


<210>  6844
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6844
gctcagccca ygcataggtt c                                               21


<210>  6845
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6845
ggtaactgcc rttcattgag t                                               21


<210>  6846
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6846
caggtattcc rgtcattggt g                                               21


<210>  6847
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6847
cgggtaagac rggagtttta c                                               21


<210>  6848
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6848
ttagttgaga rtatagcttg t                                               21


<210>  6849
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6849
cttctttccc rtggtcccaa c                                               21


<210>  6850
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6850
agtggtcata yaggctcacc t                                               21


<210>  6851
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6851
cgcaccatgc rgcgaacttg c                                               21


<210>  6852
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6852
gagtaagagc ygtttacacc g                                               21


<210>  6853
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6853
aagcagatac rtgtgtcaag g                                               21


<210>  6854
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6854
tcaatgtaat ycccacatta a                                               21


<210>  6855
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6855
tggaattata yagtaagtca c                                               21


<210>  6856
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6856
tttcacttcc ycacatctgt c                                               21


<210>  6857
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6857
taacccacat yggtttctat g                                               21


<210>  6858
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6858
ttatgttcag yttgctcatc t                                               21


<210>  6859
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6859
tgaagggatt rtatatgcac t                                               21


<210>  6860
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6860
gcttcccacc rgcaggcctt t                                               21


<210>  6861
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6861
tgactgctac mtctctcctg g                                               21


<210>  6862
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6862
tttagacttt ktattcacta t                                               21


<210>  6863
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6863
ccaggcaaga rcaggtaaaa a                                               21


<210>  6864
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6864
tatcactggt ratgttgact t                                               21


<210>  6865
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6865
ggggaagtac ygactatccc t                                               21


<210>  6866
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6866
ataaatttaa ygcaatccca g                                               21


<210>  6867
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6867
agaatcagtg rtactcacta a                                               21


<210>  6868
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6868
tcagcaaatg mtaaaagatg a                                               21


<210>  6869
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6869
caagacaatt yttttttctt t                                               21


<210>  6870
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6870
gaactgtaac ytatttatct g                                               21


<210>  6871
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6871
taattactaa ytgatgtttg t                                               21


<210>  6872
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6872
gaaggcagtg ytagaaacta a                                               21


<210>  6873
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6873
gtgaggagaa ytgtccaatg c                                               21


<210>  6874
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6874
atttaaaaaa ygggagtagg g                                               21


<210>  6875
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6875
aagaagggct raaagaaaat c                                               21


<210>  6876
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6876
caccatcatc yagatcaaga t                                               21


<210>  6877
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6877
catgaaccat ygagtccagc t                                               21


<210>  6878
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6878
atagcagccc yttcctctaa c                                               21


<210>  6879
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6879
tctggatgct ytcaaggttc t                                               21


<210>  6880
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6880
tggtacactt ratggtgtct t                                               21


<210>  6881
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6881
tcccttccct rttctggacc t                                               21


<210>  6882
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6882
aggaacttgg rgggccttaa g                                               21


<210>  6883
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6883
tatagcaggt mctcagtaag c                                               21


<210>  6884
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6884
agggtcctcc rtggatgttc c                                               21


<210>  6885
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6885
tgattaattt kggggaataa a                                               21


<210>  6886
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6886
gggggattgg mcctttcgag a                                               21


<210>  6887
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6887
gtgagatgct ktacagtggc t                                               21


<210>  6888
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6888
aactttcttc rgcaaacaac a                                               21


<210>  6889
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6889
ctaacataga yacaaggcaa c                                               21


<210>  6890
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6890
ctatgtgaca rggcaagaca a                                               21


<210>  6891
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6891
ctatatgcat ktttttttca a                                               21


<210>  6892
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6892
atagtcacta ytgatctatg g                                               21


<210>  6893
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6893
cgtaagaagt ygctgccttt t                                               21


<210>  6894
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6894
caaaacatat ytggatgagt t                                               21


<210>  6895
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6895
taatacaagg mttttccaga g                                               21


<210>  6896
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6896
gttctgcgaa yggtggaaag c                                               21


<210>  6897
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6897
tccataaaat ytatcttgaa a                                               21


<210>  6898
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6898
caccagagct rgagaactgc c                                               21


<210>  6899
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6899
atcagcattc rtgatttgtt t                                               21


<210>  6900
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6900
tcatgtaaat yataacacat t                                               21


<210>  6901
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6901
ctttgatatt mtaaggattc t                                               21


<210>  6902
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6902
taagatagaa kagtgcagtc a                                               21


<210>  6903
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6903
taagatgttt yccaatcatg t                                               21


<210>  6904
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6904
tgctcaacca ygcaagcggg a                                               21


<210>  6905
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6905
tttgagtcat rtaagattgg c                                               21


<210>  6906
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6906
cttatgttca rtgactctaa a                                               21


<210>  6907
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6907
catcctacca yaaacttgtc c                                               21


<210>  6908
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6908
taccaatgtt mgctgatagt c                                               21


<210>  6909
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6909
aaattacttt ycaaaataac t                                               21


<210>  6910
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6910
ttattgtcag mctacatcat g                                               21


<210>  6911
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6911
tttgctgcat yactatactt a                                               21


<210>  6912
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6912
tgagctttcc raaagtcatc c                                               21


<210>  6913
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6913
ttaaaagatg yggaatattg a                                               21


<210>  6914
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6914
caggttttca ygcacagctt t                                               21


<210>  6915
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6915
agtcaacaaa kattcttggg a                                               21


<210>  6916
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6916
ccaatttttc ytccccatac a                                               21


<210>  6917
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6917
acatggaatc rtctgagcaa c                                               21


<210>  6918
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6918
gtggtgtgtt rgcagctcag t                                               21


<210>  6919
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6919
tgataatcat ytctgctatg a                                               21


<210>  6920
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6920
tttggattga ytgatgtctt t                                               21


<210>  6921
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6921
agctggccgc mgctcaccag g                                               21


<210>  6922
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6922
catttcatga kgggtgtaga c                                               21


<210>  6923
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6923
gcctaagtca ytgtttattc t                                               21


<210>  6924
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6924
aggtggctga yatagtttgt a                                               21


<210>  6925
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6925
aagaaatttg yatgacagga t                                               21


<210>  6926
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6926
aacctgggtg kaaggtatga t                                               21


<210>  6927
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6927
acagtcattg raatgaagat t                                               21


<210>  6928
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6928
tgttacagaa rttaaaagag t                                               21


<210>  6929
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6929
tgacggtgct rtctcgagaa a                                               21


<210>  6930
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6930
tcacttgtca rtgttaacct g                                               21


<210>  6931
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6931
catacaaata yatacacttg a                                               21


<210>  6932
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6932
ttttgttaaa rtaaatgaac t                                               21


<210>  6933
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6933
aactatctca rcttactcta c                                               21


<210>  6934
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6934
atatggcagg ygtgattacg a                                               21


<210>  6935
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6935
aaaatagctt ygatagcttg g                                               21


<210>  6936
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6936
aatatacttc ygtcaaaaat g                                               21


<210>  6937
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6937
tggttttaca ycacttattt t                                               21


<210>  6938
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6938
agatttgcat ygctataaaa c                                               21


<210>  6939
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6939
agaatacctt ytgtttcgtt g                                               21


<210>  6940
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6940
tatgaacaga ytggcatggt a                                               21


<210>  6941
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6941
actctaaaca ytttgtcagt t                                               21


<210>  6942
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6942
tgtaacgtat yttgccatta t                                               21


<210>  6943
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6943
acatgcctga rtcttacttg t                                               21


<210>  6944
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6944
gtatttacta ytccatactt g                                               21


<210>  6945
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6945
gtttgagact macctgtaat g                                               21


<210>  6946
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6946
aaggtttgtt rtgcagattt g                                               21


<210>  6947
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6947
ttctctgcct mgtgtggtta c                                               21


<210>  6948
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6948
gccaaggtag rtgttgccta t                                               21


<210>  6949
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6949
cgttagggcc mcatcaaagg a                                               21


<210>  6950
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6950
aaagtcctgc raagaaaata c                                               21


<210>  6951
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6951
ttggcttatc rgttactgta g                                               21


<210>  6952
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6952
gtcacttttc ytggctttgg g                                               21


<210>  6953
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6953
gctccaaaac yggcttcaaa a                                               21


<210>  6954
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6954
gtggccaccc rgaaacagct t                                               21


<210>  6955
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6955
cagccctggc rcgtctgtgt g                                               21


<210>  6956
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6956
gaagccttct ytagtcccaa c                                               21


<210>  6957
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6957
tggaatctgc rtttttttgt t                                               21


<210>  6958
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6958
aaattcatac rtactgaata g                                               21


<210>  6959
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6959
ccttcctcct ygcccttgtc t                                               21


<210>  6960
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6960
atggatgtac rtgcctccta g                                               21


<210>  6961
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6961
tttacttact rcccacaagt c                                               21


<210>  6962
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6962
aacgagacaa mcctggaacc t                                               21


<210>  6963
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6963
gggccttcca rgcccaggac g                                               21


<210>  6964
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6964
aatgtgtgaa yggatgatgg a                                               21


<210>  6965
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6965
catgttgaat raataataga c                                               21


<210>  6966
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6966
caaacactcc ytgagcccct a                                               21


<210>  6967
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6967
ctcgggaacc ygggacattg g                                               21


<210>  6968
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6968
agtcatctgt rtcgccctca g                                               21


<210>  6969
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6969
ttcctgttca ktgtattctg c                                               21


<210>  6970
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6970
ctctccagaa kgatttgcac a                                               21


<210>  6971
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6971
tccatcctaa ygtcagcagt a                                               21


<210>  6972
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6972
cctttcccct ygggtgcctc c                                               21


<210>  6973
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6973
gtgagttttc yttgagttgg g                                               21


<210>  6974
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6974
ctgtagctgt ygaatttggt g                                               21


<210>  6975
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6975
gcttctgcct rttcccctcc c                                               21


<210>  6976
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6976
gcacttctat raagtagaca a                                               21


<210>  6977
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6977
tggattctca ygcattttaa c                                               21


<210>  6978
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6978
ttaaattgta ygaccaaatg t                                               21


<210>  6979
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6979
aacatattct yataggctga c                                               21


<210>  6980
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6980
taggttgtca rtttttctcc c                                               21


<210>  6981
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6981
atatctatga ygaacttcaa a                                               21


<210>  6982
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6982
tacaggacac raggttaata t                                               21


<210>  6983
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6983
tcctgtaagc kggcttaagt t                                               21


<210>  6984
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6984
taaagacaat yaatgtgcat a                                               21


<210>  6985
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6985
gtcagctgtt rtgtcctata a                                               21


<210>  6986
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6986
tctttactgc ytagagataa c                                               21


<210>  6987
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6987
gatggaactc rttggcttga a                                               21


<210>  6988
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6988
tcattaagct ktagggttct c                                               21


<210>  6989
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6989
tccaagatac rttaggaaaa t                                               21


<210>  6990
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6990
agagagactt rgacactatc a                                               21


<210>  6991
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6991
atgtagaaaa yaaaaataga t                                               21


<210>  6992
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6992
cttaaccagt racctatata t                                               21


<210>  6993
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6993
tgccagatac rttggtgtga t                                               21


<210>  6994
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6994
gaatacaaat yagccaggga t                                               21


<210>  6995
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6995
atgcaatcgt kgtgtttcaa a                                               21


<210>  6996
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6996
cactagaata mcatgttata t                                               21


<210>  6997
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6997
cacgattgag rcaaacaaca t                                               21


<210>  6998
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6998
cactaaacat ygattggagt g                                               21


<210>  6999
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  6999
atttcattga ycagcttgga c                                               21


<210>  7000
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  7000
tttgaccagt rtgtcatcaa a                                               21


<210>  7001
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  7001
gaagcatgtg rctataggga a                                               21


<210>  7002
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  7002
tccatgatac ygagaagcag g                                               21


<210>  7003
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  7003
gcctccaacg ytgtatttct g                                               21



<210>  7004
<211>  21
<212>  DNA
<213>  Homo sapiens

<400>  7004
tggtggactc ractgtgaca c                                               21
